bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-invasive diagnostic test for cow's milk allergy: A cross-sectional, descriptive study
Authors: Raziani Yosra , Othman Brwa , Ahmad Asuda , Qadir Sozyar 
Published: April 2022

Background: Cow's milk allergy is a common type of allergy in infants that is caused by the immune response to proteins in cow's milk. Digestive manifestations, atopic dermatitis, and respiratory discomfort are some of the clinical manifestations that appear; however, none of them are objective criteria to confirm the diagnosis, which may result in misdiagnosis, treatment hindrance, and parental concerns. Therefore, new methodologies for an accurate and immediate diagnosis is essential.
Methods: In this descriptive study, infants referred to the pediatric health center in Sulaymaniah were selected during a period of 1 year. The data were collected using a demographic questionnaire and the Cow's Milk Related Symptom Score (CoMiSS). Chi-squared and independent t tests were used to analyze the data.
Results: The findings of the present study indicated that among 250 infants (117 boys, 133 girls), with a mean ± SD age of 2.9 ± 1.6 years, 21% were breastfed, 39% were fed both cow's milk and breast milk, and 60% were fed only cow's milk. The contingency of cow's milk allergy was positive in 35% of infants. According to this questionnaire, 18% of the participants got a score of 0–5, 47% scored 6–11, and 35% scored ≥ 12. A significant relationship was found between cow's milk allergy and the participants’ diet (p < 0.001). A significant association was also found between age-dependent growth index (weight p = 0.04, height p = 0.01, and head circumstance p = 0.02) and cow's milk allergy.
Conclusion: Although common problems in infancy such as colic and reflux may interfere with an accurate diagnosis of cow's milk allergy, give false-positive results, and decrease the reliability of CoMiSS; there is a need for non-invasive and easy methods for early diagnosis and improving awareness to encourage parents to take preventive measures.
Foreign body aspiration in an adult: An endobronchial “Melon-oma”
Authors: Ul Haq Irfan , Hameed Mansoor , Ahmed Shakeel , Hussein Mousa 
Published: April 2022

Background: Foreign body (FB) aspirations in adults are relatively uncommon. The most commonly aspirated FBs in adults are organic, especially vegetable matter, peanuts, and fragments of bones. We report a rare case of a FB discovered in the left main bronchus of an adult male admitted to the intensive care unit. Case report: A 52-year-old male smoker with COPD presented to the emergency department with a two-day history of increasing dyspnea and cough. He was hypoxic and febrile with a temperature of 38°C. Auscultation revealed decreased breath sounds over the left lung and a few rhonchi on the right side. Chest x-ray showed left lung collapse. His condition rapidly worsened, and he was immediately intubated for acute respiratory failure. CT chest identified a large endobronchial mass obstructing the left main bronchus. Flexible bronchoscopy confirmed a soft and mobile brownish lesion in the left main bronchus. The histological appearance of the specimen retrieved was consistent with an organic foreign body. This was later identified as a melon chunk. It was removed successfully via flexible bronchoscopy by cutting it into smaller pieces to aid retrieval. Conclusion: FB aspiration can occur in all age groups but is less common in adults accounting for only 0.16%–0.33% of adult bronchoscopic procedures. Early detection of an aspirated FB is essential to avoid significant complications, morbidity, and mortality.
Pre-procedural SARS-CoV-2 PCR testing in the pulmonary function laboratory at a tertiary government hospital in Qatar: A clinical audit
Authors: Parveen Fida , Thomas Merlin , Hameed Mansoor , Raza Tasleem , Panneerselvam Balamurugan , Nair Rajalekshmi , Ahmed Mushtaq , Ul Haq Irfan , Al Mohammed Ahmed , Abdul Sattar Hisham 
Published: April 2022

Background: Prior to pulmonary function testing (PFT), local and international recommendations advise pre-procedural screening. Pulmonary function tests generate aerosol droplets containing millions of viruses, significantly increasing the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission not only to the individuals in and around the PFT office, but also to subsequent patients who undergo the test later in the same room.
Methods: This clinical audit was carried out to establish the rate of positive pre-procedural SARS-CoV-2 PCR testing before a PFT. The data were obtained over a 6-week period from our ATS accredited pulmonary function laboratory at the Hamad General Hospital, Qatar (December 01, 2021, to January 10, 2022). The PFT laboratory was closed from January 10, 2022, till the date of this report (January 27, 2022) owing to an increase in COVID cases in the community in Qatar during the fourth wave.
Results: All the patients scheduled for PFT were asymptomatic of COVID-19. A total of 331 individuals were scheduled for PFT, and 221 PFTs were performed. There were 109 no-shows for both the PCR and the PFT. Between weeks 1 and 4, all the pre-procedural SARS-CoV-2 PCR tests were negative. The weekly average number of COVID-19 cases in Qatar increased from 157 per 100,000 population in week 1 to 2,918 in week 6.2 There was a similar trend in the pre-procedural SARS-CoV-2 PCR tests that increased and resulted in identifying 9 cases with positive SARS-CoV-2 PCR test over weeks 5 and 6 ().
Conclusion: As the number of documented positive SARS-CoV-2 PCR tests in the community grew, so did the pre-procedural COVID-19 PCR positivity and the number of no-shows. The large number of no-shows may indicate greater worry or concern about contracting COVID-19 when visiting the hospital amid peak community cases. Our findings further call into question the utility of routinely performing pre-procedural PCR screening in asymptomatic cases when the prevalence of COVID-19 is low in the local population. Perhaps, it is time to consider replacing this with on-the-spot quick antigen testing for more effective use of resources.
Selective COX-2 inhibitor continues to be a safe alternative in patients with nonselective NSAIDs hypersensitivity
Authors: Thalappil Sherin , Al-Nesf Maryam 
Published: April 2022

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) cause different types of allergic and pseudo allergic reactions. This results in difficulties in clinical practice. Most cases of NSAID hypersensitivity are mediated by the inhibition of cyclooxygenase-1 enzyme (COX-1), which results in depletion of the protective prostaglandin E2, and promotes the unrestrained synthesis of inflammatory mediators from mast cells. Selective COX-2 inhibitors are considered safe alternatives in patients with NSAID allergy, although hypersensitivity reactions to COX-2 inhibitors have also been reported. Our study aimed to report the experience in Qatar for using COX2 inhibitors as an alternative treatment for nonselective NSAID allergy.
Methods: Data of patients who underwent open challenge with a single dose of oral celecoxib 200 mg were retrieved from the procedure log of the Allergy and immunology Division in Hamad medical corporation, Doha, Qatar, from 2013 to 2022. The challenge was considered positive if the patient developed cutaneous or respiratory symptoms.
Results: A total of 31 patients were identified; 4 with a history of celecoxib allergy. The remaining 27 (23 females and 4 males); with mean ( ± SD, range) age of 42 ( ± 12, 20–65) years had hypersensitivity to one (n = 11) or more than one (n = 16) nonselective NSAID, manifested as cutaneous, respiratory, or anaphylactic symptoms. Those 4 patients with celecoxib allergy were challenged and only one with a historical reaction of anaphylaxis developed anaphylaxis during the challenge. Celecoxib was well tolerated in all 27 patients with hypersensitivity reactions to nonselective NSAIDs. Also, patients were contacted by telephone call at 24 hours and after 1 week with no evidence of delayed reactions.
Conclusions: Selective COX-2 and nonselective NSAIDs have similar overall efficacy as analgesic, anti-inflammatory, and antipyretic agents. Hypersensitivity reaction to COX-2 inhibitors has been reported; however, it is rare. So, it is safer to challenge the patients with COX-2 inhibitors before prescribing them as alternative medication in patients with Nonselective NSAID allergies. We plan to conduct a single-/double-blind placebo-controlled study for more patients, especially using graded challenges for high-risk profile candidates. Also, it may be of significance to test more than one type of selective COX-2 to avoid drug-specific reactions.
Contributions of nurse specialists in the allergy and immunology service and patient care
Authors: Ibrahim Yaldez , Bin Naji Slim , Mobayed Hassan , Al-Nesf Maryam 
Published: April 2022

Specialist nurses have a crucial role within the allergy and immunology specialty that reflects their competence in an increasingly complex area of work and ability to use advanced diagnostic testing and therapeutic modalities. A specialist nurse in Qatar follows the local Hamad Medical Cooperation (HMC) guidelines and the competency published by the British Society for Allergy and Clinical Immunology (BSACI).
Specialist Allergy Nurses
Learning domain: Learn and review the written standard operating procedure (SOP) and protocols for all diagnostic and therapeutic allergy procedures, including skin prick testing (inhaled, food, and others), intradermal testing, skin patch testing, penicillin testing, food and drug challenges, different desensitization protocols, and biologics and other medication administration. In addition, learn the protocol for immunotherapy administration and maintain an updated knowledge of trends and developments in the field by reading relevant articles, journals, and related material and attending seminars and conferences, as needed.
Maintain a safe work environment: Perform all the above procedures and medication administration with a high grade of competency under physician supervision. Apply quality measures to ensure safety. Furthermore, perform stocktaking by regularly checking procedure requirements, availability of items and consumables, date of expiry of items, and medications. Monitor the patients closely during drug and food allergy challenge procedures and record and report patients’ vitals and reactions to treating physicians. Ensure that a patient stays the required observation time after injection(s).
General care: Assess patient needs and suggest solutions to patient care problems. Provide education and resources for the patient and family support as needed. React appropriately and on time during patient reaction situations to mitigate early adverse reactions. Maintain patient, employee, and clinic confidentiality.
Specialist Immunology Nurses

• Develop specialist knowledge and experience in immunology.

•Develop nurse-led clinics for administering immunoglobulin replacement therapy safely and effectively based on patients’ preferences (IV vs. SC and in-hospital vs. home programs).

•Coordinate communication between members of the multidisciplinary team to facilitate the appropriate delivery of care.

•Provide education and resources for the patient and family support (insurance issues, resources for vaccination recommendations, concerns regarding traveling and vacations, pregnancy, and any other lifecycle changes).
Strategi Guru Akidah Akhlak dalam Pembentukan Akhlak Siswa di Mts Ma’arif Karangasem Bali
Authors: Mustofa Ali , Ali Firman Ali Firman 
Published: April 2022

Akhlak adalah suatu yang sangat penting. Penelitian ini membahas penerapan strategi pembelajaran guru akidah akhlak dalam pembentukan akhlak siswa di MTs Ma’arif. Tujuan penelitian ini adalah untuk mengetahui strategi guru akidah akhlak, akhlak siswa, dan faktor pendukung dan penghambat dalam pembentukan akhlak. Untuk mendapatkan jawaban terhadap permasalahan di atas maka penulis melakukan penelitian dengan kualitatif, Setelah melakukan analisis terhadap data yang diperoleh maka hasilnya menunjukkan adanya peningkatan akhlak siswa di MTs Ma’arif, yang meliputi sifat al-amanah (setia, jujur dan dapat dipercaya), al-wafa (menepati janji), tawadhu’ (rendah hati) dan benar/jujur. Semua itu bisa dicapai melalui penerapan strategi pembelajaran dengan berbagai macam strategi pembelajaran yaitu strategi pembelajaran langsung, inkuiri dan kooperatif. Adapun proses penerapan strategi pembelajaran tersebut yang secara umum dilakukan melalui tiga tahap yaitu tahap permulaan (praintruksional), tahap pengajaran (intruksional) dan tahap penilaian tindak lanjut.Implikasi dalam penelitian ini adalah, berbagai proses penerapan strategi pembelajaran guru akidah akhlak dalam pembentukan akhlak siswa di MTs Ma’arif harus tetap diterapkan, dan ditingkatkan dengan berbagai kreativitas yang mampu menunjang proses pembinaan akhlak mulia bagi peserta didik. Selain itu, upaya maksimal yang telah dilakukan guru akidah akhlak dalam pembentukan akhlak mulia peserta didik juga perlu inovasi dengan semakin menggali potensi-potensi sumber daya pendidikan yang ada guna pembinaan yang berkelanjutan. Dukungan seluruh aspek pendidikan hendaklah sejalan dengan program pembentukan yang dilakukan guru akidah akhlak, turutama keteladanan, pembiasaan dan pengawasan dalam lingkungan keluarga, masyarakat dan sekolah.
Canvas Model Business Design (BMC) in Karawang Batik Production Business at Bale Batik Taza Karawang
Authors: Sukmasari Lina , Suyaman Dede Jajang , Hartelina Hartelina 
Published: April 2022

The research objective is to implement the Design strategy to develop the Karawang Batik Business by using the design of the nine elements of the Canvas business model which includes Customer segment, value proposition, channel, customer relationship, revenue stream, key resources, key activities, key partnership, cost structure. This Canvas Model is expected to be able to overcome and provide solutions to problems and obstacles from all activities or activities at Bale Batik Taza Karawang which until now seems to have not been fully implemented so that researchers want to create, map, design, and direct what indicators should be improved to build a business that it can produce maximum production, marketing, and sales. The type of research used is descriptive with a qualitative approach method. The research location was conducted at Bale Batik Taza, KH. Ahmad Dahlan street No.20 at Karawang city. Respondents were carried out purposively by considering the factors of understanding the company's strategy, company conditions, internal conditions, business models, the company's main competitors. alternative Strength–Opportunity strategy as a strategy to use strengths to take advantage of existing opportunities. The conclusion of the research that can be found is that the mapping of the Canvas business model run by Bale Batik Taza Karawang has not been maximally implemented. Some elements that need to be improved are Key partnership, Key Resource, Key Activity, Customer Relationship, Customer segment, Channel, and Cost Structure. While the approach using SWOT analysis should be more maximal in developing its business innovations such as expanding marketing strategies, networking with vendors, and the quality of the various designs and variations of the typical Karawang batik patterns that are packaged according to consumer demand so that they will be satisfied with the results of the pattern designs made. The strategy is carried out using the S–O, S–T, W–T, and W-O to determine how many strategies can be used to build and develop the Karawang Batik Business at Bale Batik Taza Karawang so that it can increase.
OPTIMASI FORMULASI SEDIAAN HANBODY LOTION DARI EKSTRAK KULIT JERUK BALI ( Citrus maxima (Burm.) Merr. ) SEBAGAI ANTIOKSIDAN
Authors: Syam Ai A’yunin , Marini Marini 
Published: April 2022

Kulit jeruk bali dapat digunakan sebagai antioksidan alami, tanaman ini mengandung flavonoid, vitamin c, senyawa alkaloid, pektin dan tanin. Tanaman ini dibuat ekstrak dan dijadikan kedalam bentuk sediaan handbody lotion karena dapat digunakan sebagai pelindung kulit dari radikal bebas dan penyebarannya cepat merata pada permukaan kulit yang luas.Kulit adalah lapisan atau jaringan yang menutup seluruh tubuh dan melindungi tubuh dari bahaya yang datang dari luar.Lotion merupakan sediaan cair berupa suspense atau disperse digunakan sebagai obat luar. Tujuan dari penelitian ini untuk mengetahui ekstrak kulit jeruk bali dapat diformulasikan dalam bentuk sediaan handbody lotion. Dalam penelitian ini pembuatan ekstrak menggunakan metode maserasi. Penelitian ini dibuat menjadi 3 formula dengan perbandingan basis lotion setil alkohol dan lanolin. formula 1 setil alkohol 3% dan lanolin 1%, formula 2 setil alkohol 2% dan lanolin 2%, formula 3 setil alkohol 1% lanolin 3%. Handbody lotion dievaluasi meliputi uji organoleptis, uji pH, uji homogenitas, uji daya lekat dan uji daya sebar. Dan hasil menunjukkan formula 1 dan 2 dapat diformulasikan menjadi sediaan handbody lotion, hasil evaluasi uji pH F1 6 F2 6 yaitu memenuhi syarat pH kulit 4,5-8, hasil uji daya sebar F1 beban 0 gr 5 cm, beban 100 gr 5,5 cm, beban 200 gr 6 cm dan F2 beban 0 gr 5 cm, beban 100 gr 5 cm, beban 200 gr 5,5 cm, uji daya sebar F1 dan F2 memenuhi syarat 5-7 cm, hasil uji daya lekat F1 09,3 detik, F2 05,3 detik yaitu memenuhi syarat uji daya lekat lebih dari 4 detik. Hasil uji homogenitas F1 homogen, F2 homogen.Sedangkan F3 tidak dapat diformulasikan menjadi sediaan handbody lotion karena pada uji evaluasi lotion tidak memenuhi syarat homogenitas.
Profil Penggunaan Obat Antidiabetik Oral Pada Pasien Diabetes Mellitus Tipe II Di Apotek Annisa 24
Authors: Ramadhan Ilham Fajar , Diputra Angga Anugra 
Published: April 2022

Profil penggunaan obat Antidiabetik Oral adalah keadaan atau potensi dan gambaran mengenai penggunaan obat Diabetes Mellitus Tipe II. Setiap resep Antidiabetik Oral yang datang ke Apotek Annisa 24 ditulis oleh dokter yang berbeda- beda. Penelitian ini bertujuan untuk mengetahui profil penggunaan obat Antidiabetik Oral berdasarkan nama obat, golongan obat, jenis obat, jenis terapi Diabetes Mellitus, frekuensi penggunaan obat, jenis terapi obat, dan jenis kelamin pasien di apotek annisa 24. Penelitian ini dilakukan dengan metode Retrospektif. Data yang diambil berupa 84 lembar resep obat antidiabetik oral di apotek annisa 24 pada periode tahun 2020. Hasil penelitian menunjukan, Penggunaan obat Antidiabetik Oralterbanyak yaitu obat metformin sebanyak (43%). Golongan obat Antidiabetik Oral terbanyak yaitu golongan biguanida yaitu sebanyak (57%). Jenis obat Antidiabetik Oral yang paling banyak digunakan yaitu jenis generik sebanyak (98%). Frekuensi penggunaan obat yang paling banyak yaitu, menggunakan metformin 500mg dengan frekuensi 1 kali sehari (33%). Jenis terapi tunggal adalah paling banyak diresepkan yaitu sebanyak (87%). Untuk jenis kelamin, pasien perempuan paling banyak mengidap Diabetes Mellitus yaitu sebanyak (61%).

Kata Kunci : Antidiabetik Oral , Apotek , Diabetes MellitusTipe II ,Profil Penggunaan , Resep
Two Capacitor Problem with a LTI Capacitor and a Capacitor Modelled Using Conformal Fractional Order Derivative
Authors: PALAZ Utku , MUTLU Reşat 
Published: April 2022

Fractional order circuit elements have been started to model different types of circuit elements, circuits and systems in the last decades. There are different types of fractional derivatives. Recently, a new simple fractional derivative method called“conformable fractional derivative” has been brought out. It is simpler than other fractional derivatives and has already been used tomodel supercapacitors. It is important to model the new circuit elements and analyze the circuits containing them so that they can be exploited at their full potential. Two capacitor problem is a famous problem in physics and circuit theory. In this study, a new two capacitor problem a circuit which consists of an LTI capacitor and a supercapacitor which has been modelled with conformable fractional derivative have been examined. The differential equations which describe the circuit have been derived. The circuit current is found explicitly however the voltages of the capacitors do not have analytical solutions. That’s why they are solved numerically.
Emotion Detection from Facial Expression Using Different Feature Descriptor Methods with Convolutional Neural Networks
Authors: ALTEKİN Fatih , DEMİR Hasan 
Published: April 2022

In this article, image processing techniques to detect facial emotion expressions are examined. Studies done to detect facial expression are given in stages. The success of the convolutional neural networks (CNN) method in emotional expression has been investigated. A set of 981 CK + pictures containing human faces in 7 emotion categories was used. The success rates when using HOG, LBP, Wavelet feature of images and the original state of the images in the data set were compared.
Sources and Health Benefits of Functional Food Components
Authors: Shaikh Saijuddin 
Published: April 2022

Functional foods are the foods claimed that have additional health benefits beyond their basic nutritional values, and functional food components are bioactive, potentially beneficial compounds that are found either naturally in foods or added to them as functional ingredients. Some important functional food components are carotenoids, isothiocyanates, soluble and insoluble dietary fiber, phenolic acids, fatty acids, plant stanols and sterols, flavonoids, polyols, soy protein, prebiotics and probiotics, phytoestrogens, vitamins, and minerals. Most of the functional food components occur mainly in plant foods (whole grains, fruits, and vegetables), however, few functional foods components, such as omega-3, -6, and -9 polyunsaturated fatty acids are also found in animal products (e.g. milk, fermented milk products, and cold-water fish). Evidence suggested that there is a relationship between functional food components and health benefits. Functional food components can be used for the treatment and prevention of different diseases. Biologically active functional food components can reduce the risk of certain non-communicable diseases, such as cancer, type II diabetes, cardiovascular diseases, osteoporosis, inflammation, and lowering of blood cholesterol. Thus, people should consume a wide variety of foods to assure the ingestion of functional food components in their body, such as fatty acids, fiber, carotenoids, flavonoids, prebiotics and probiotics, vitamins, and mineral.
Relationship dissolution strategies: Comparing the psychological consequences of ghosting, orbiting, and rejection
Authors: Pancani Luca , Aureli Nicolas , Riva Paolo 
Published: April 2022

Ghosting and orbiting occur when a relationship is ended unilaterally by suddenly withdrawing from all communication and without explanation. However, in orbiting, the disengager still follows the victims on social networking sites after the breakup. With the advent of the digital era, these practices have become increasingly common, gaining attention from psychology research. Within the theoretical framework of social exclusion, the present study (N = 176) investigated victims’ consequences of ghosting and orbiting, considering the two breakup strategies as instances of ostracism. Participants were invited to fill an online survey and randomly assigned to recall an episode of ghosting, orbiting, or rejection. Following the recall task, participants completed a series of questionnaires to measure the typical outcomes threatened by ostracism (i.e., emotions, basic psychological needs, breakup’s cognitive evaluation, and aggressive inclinations). The results showed a consistent pattern across most of the constructs measured. Specifically, ghosting led to worse outcomes than rejection, whereas the disengagers’ ambiguous signals characterizing orbiting seemed to buffer the victims partially from the consequences of relationship dissolution. Results are discussed in the light of social exclusion literature, adding to the growing research on ghosting.