bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibodies and antibody fragments are therapeutic tools in the treatment of type-II diabetes mellitus
Authors: Thimmaraju Manish Kumar , Boddeda Bhavani , Laskar Sahin Alamin , Vanamala Mounika , Uzma Uzma , Laskar Kabir Hussain , Islam Aminul , Devarakonda Navya Shirisha , Ahmed Nahim , Khan Mohammed Moiz , Alom Jakaria , Billah A. Mohathasim 
Published: April 2022

Antibody fragments (FABs) are proteins that form part of the antigen recognition site. FABs are produced in genetically modified bacteriophages, bacteria, fungi, or plants and, consequently, can be produced in large quantities at a fraction of the cost of traditional antibodies. Antibody fragments are small and simple structure that today is highly regarded because of the many advantages they have over the use of whole antibodies. Single-domain antibodies are the smallest antigen-binding units of antibodies, consisting either only of one variable domain or one engineered constant domain that solely facilitates target binding. Fibroblast growth factor 21 (FGF21) is a promising drug candidate for the treatment of type 2 diabetes. Clinical use of recombinant fibroblast growth factor 21 (FGF21) for the treatment of type 2 diabetes and other disorders linked to obesity has been proposed; however, its clinical development has been challenging owing to its poor pharmacokinetics.
Effectiveness of instructional program on parents’ knowledge concerning etiologies and clinical manifestation of picky eating behavior among children under five years of age
Authors: Shaker Wameedh Hamid , Al-Mosawi Khatam M. 
Published: April 2022

Objective: To assess parents’ knowledge concerning etiologies and clinical manifestation of picky eating behaviors. To determine the effectiveness of instructional program on parents’ knowledge through comparing the knowledge scores at the pre-test and post-test. Methodology: To achieve the aims of this study, this quasi-experimental design was conducted on children suffering from picky eating behavior assigned to study and control groups is used to study the effectiveness of instructional program on parents' knowledge toward dietary patterns for children with picky eating behavior at Al-Zahra Teaching Hospital in Al-Najaf Al-Ashraf City. Questionnaires were developed to determine the effectiveness of the instructional program on parents' knowledge toward dietary patterns for children with picky eating behavior. The final instruments consisted of (4) parts First: concept of picky eating behavior in children (Includes four questions) Second: causes of picky behavior and dangerous factors (Includes eight questions) Third: symptoms of picky behavior (It includes six questions) Fourth: importance of a child's picky eating behavior diet (It consists of seven questions) Fifth: ways to deal with the child picky eating behavior in food (It contains seven questions) Sixth: therapeutic and guiding measures for picky eating children (It has thirteen questions).
Enrique Fuentes Quintana: el falangista que leía a Keynes (1948-1957)
Authors: Martorell Linares Miguel 
Published: April 2022

Enrique Fuentes Quintana fue uno de los economistas españoles más importantes del pasado siglo xx. En los años de su formación fue un ávido lector de John Maynard Keynes, quien influyó de manera notable en los escritos que publicó al comenzar su carrera profesional. Por aquellos años, además, Fuentes Quintana se implicó de forma activa como publicista, desde las páginas del diario Arriba, en la campaña falangista para definir el perfil ideológico e institucional del régimen. Este artículo analiza los escritos que publicó entre los años 1948 y 1957.
Analisis CPO, Asam Fosfat dan Soda Api Sebagai Pengganti Bahan Bakar Minyak (BBM) Mesin Diesel Dengan Variasi Campuran 98%, 1%, 1% Dan 95%, 2%, 3%, dan 95%, 3% 2% Mengunakan Pengujian Kalor
Authors: Putra Muhlas Adi , Gunawan Yuspian , Hasanudin La 
Published: April 2022

Energy needs continue to grow as the industry develops and the world's population grows. The growing need for fuel oil is causing fewer crude inventories. So we did research on Cpo Analysis, Phosphoric Acid And Fire Soda In Lieu of Fuel Oil (Fuel) Diesel Engines With Mixed Variations 98%, 1%, 1% And 95%, 2%, 3%, And 95%, 3% 2% Using Calorific Testing. Go to this study to find out the calorific value and combustion rate of the biodiesel ed. The results of the study in three biodiesel experiments that were most effective for use were shown in the trial to three CPO 95%, 3% posephuric acid and 2% fire soda with a combustion rate of 0.309 gr/min within 30.42 minutes with a final temperature of 57oC. In the three most effective biodiesel experiments to use, three CPO 95%, 3% asamposfat and 2% soda api witha calorific value of 8208.39 cal/gr with a final temperature of 57oC. In the manufacture of biodiesel that affects from the mixture of chemicals as much as soda fire will be better and the less phosphoric acid it will be good. Keywords: Biodiesel, Calorific Value, and Combustion Rate
High alpine sorcerers: revision of the cave wētā genus Pharmacus Pictet & de Saussure (Orthoptera: Rhaphidophoridae: Macropathinae), with the description of six new species and three new subspecies
Authors: Hegg Danilo , Morgan-Richards Mary , Trewick Steven A. 
Published: April 2022

The New Zealand alpine cave wētā genus Pharmacus was first described by Pictet & de Saussure (1893) as a monotypic taxon. Three species were added to the genus by Richards in 1972. Here we clarify the status and appearance of all known species of Pharmacus. Based on morphology and mtDNA sequences we determine that the species Pharmacus brewsterensis Richards, 1972 is better placed within the genus Notoplectron Richards, 1964. We also resolve the species Isoplectron cochleatum Karny, 1935 and show that it belongs to the genus Pharmacus. Additionally, we describe six new species and three new subspecies from the southern regions of South Island, New Zealand. We provide key traits and known distributions for all known species and subspecies in this alpine genus. New combinations: Pharmacus brewsterensis Richards, 1972 becomes Notoplectron brewsterense (Richards, 1972) comb. nov.; Isoplectron cochleatum Karny, 1935 becomes Pharmacus cochleatus (Karny, 1935) comb. nov. New species and subspecies: Pharmacus cochleatus rawhiti subsp. nov., Pharmacus cochleatus fiordensis subsp. nov., Pharmacus cochleatus nauclerus subsp. nov., Pharmacus concinnus sp. nov., Pharmacus cristatus sp. nov., Pharmacus notabilis sp. nov., Pharmacus perfidus sp. nov., Pharmacus senex sp. nov. and Pharmacus vallestris sp. nov. New synonyms: Pharmacus dumbletoni Richards, 1972 = Pharmacus montanus Pictet & de Saussure, 1893 syn. nov.; Pharmacus chapmanae Richards, 1972 = Pharmacus cochleatus (Karny, 1935) syn. nov.
Malita LGU Officials Leadership Practices and Employees’ Perception on Readiness to Work from Home Arrangement
Authors: P. Mahinay Maybeline , D. Bongao Jocel , C. Franca Glenford 
Published: April 2022

Aims: To know the level of the leadership practices of the officials in terms of modelling the way, inspiring a shared vision, challenging the process, enabling others to act and encouraging the heart. And, to know the level of LGU’s readiness to work from home as perceived by the municipal employees.
Study Design: Descriptive-correlational.
Place and Duration of Study: Malita, Davao Occidental, Southern Philippines during the School Year 2020-2021
Methodology: This involved the systematic investigation of the nature of relationships, or associations between and among dependent and independent variables and was most commonly used when seeking statistical relationship between two variables without manipulating the data themselves. Leadership practices of LGU and LGU employees' readiness to work from home arrangement as perceived by the following domains, such that of model the way, challenge the process, enable others to act, and encouraging the heart increase, the level of employees' preparedness to work from home also increases.
Conclusion: Since the level of inspire a shared vision, one of the leadership practices domains, increases, the LGU officials need to know its meaning and open themselves into communication structure that allowed employee to participate. The more optimistic a leader about the future, the more effectively he or she may transmit it to others. Studies related to this topic were hereby recommended.
Institutional Analysis of the Bacteriological Profile and Antibiotic Susceptibility of the Neonatal Sepsis in Eastern Nepal
Authors: Das Ramesh Prasad , Yadav Pankaj Kumar Thadhiya , Yadav Rambabu , Sheikh Sadaf Saleem , Yadav Dipak Kumar 
Published: April 2022

Introduction: In the developing nations, neonatal sepsis account for the larger portion of the neonatal morbidity and mortality. Blood culture is considered as the gold standard for the diagnosis. Both, the conformation and management is difficult for clinicians in the resource limited nations like Nepal.
Method: It is a retrospective observational study conducted at one of the tertiary care hospital in eastern Nepal over a year.
Result: Incidence of neonatal sepsis was 12.9%. The incidence of blood culture positivity in the neonatal sepsis was 15%. Coagulase negative Staphylococcus species and Escherichia coli were two most predominant organism isolated. All of the isolated Klebsiella spp. and Pseudomonas spss.showed resistance to ampicillin whereas 100% of Coagulase Negative Staphylococcus spp. showed sensitivity to vancomycin.
Conclusion: Isolated bacteria showed resistance to multiple antibiotics. This is an alarming moment for the pediatrician. Antibiotics should be used judiciously and continuous surveillance should be done to monitor the changing epidemiology of organisms and antibiotic sensitivity as the emergence of resistance to commonly used antibiotics is high.
Psychiatric Comorbidities among University Students with Relapsing-Remitting Multiple Sclerosis
Authors: Mustafa Wessam , Salama Samer , Jawad Mohamed , Elkalla Ibrahem , El Rashedy Shady , Abbas Mohammed 
Published: April 2022

Background: Multiple sclerosis (MS) has been reported to be associated with psychological manifestations like depression, anxiety, and depression. Its presence in university students may impact their academic performance. As the relapsing-remitting type (RRMS) is the commonest MS type, we conducted this study to evaluate the prevalence and severity of the previous psychological manifestations in University students diagnosed with RRMS. The impact of MS on their academic performance was also assessed.
Patients and Methods: This case-control study included 65 students diagnosed with RRMS in addition to the same number of healthy controls. Psychological manifestations were evaluated via the Arabic form of DASS (depression, anxiety, and stress score), while academic performance was assessed via the GPA (grade point average).
Results: Patient criteria, including age and gender, were statistically comparable between the two groups. The three components of DASS expressed significantly higher values in cases compared to controls, indicating increased prevalence and severity of psychological issues in association with RRMS. MS was associated with a significant decline in the student’s academic performance as had median values of 1 and 3 in cases and controls, respectively.
Conclusion: MS is associated with a significant increase in both prevalence and severity of depression, anxiety, and depression compared to the normal healthy population. MS also has a significant negative impact on the academic performance of these students.
Evaluating Teaching and Learning Modalities in Higher Education: The Case of BAMS Students
Authors: Borage Swapnil , Rathi Bharat , Shelotkar Priyanka , Dangore Suvarna 
Published: April 2022

Background: During the COVID-19 pandemic, institutions were obliged to change the teaching methods, as conventional teaching methods were not adoptable for the legislations of COVID-19 protocols. Students in large number started enrolling in the online courses. The reviews about the effectiveness of the online teaching were mixed reviews when focused on academic achievement. Many learners and teachers also opine that, traditional teaching is still a better option to online teaching. Blended teaching is a way to unite the two teaching methods and can be useful in overcoming the shortcomings of both the teaching learning methods.
Objectives: To compare understanding of topic by final year BAMS students, using Conventional teaching, Online teaching, and Blended teaching.
Methodology: 70 students from final year BAMS, will be selected for the study, which will be taught by Conventional, online and Blended method, in rotation. A pre test and post test will be conducted to get the results.
Results: The data will be analyzed to identify the effectiveness of the teaching method, in terms of difference in the mean Pre test and Post test scores.
Conclusion: If found effective, educational institutions must adopt blended teaching method over traditional and online teaching method to the larger favor of students
Frequency of Common Congenital Anomalies among Neonates in Tertiary Care Hospital: A Cross-sectional Study
Authors: Ul Ain Skeikh Noor , Hamid Shaikh Abdul , Rafique Khokhar Iqra , Larik Sobia , Rehman Shaikh Abdul , Nadeem Chohan Muhammad 
Published: April 2022

Aim: To determine the frequency of common congenital anomalies among neonates in tertiary care hospital
Study Design: A cross-sectional study.
Place and Duration: Children Hospital Larkana Pakistan from April to October 2018.
Methodology: One hundred twenty-four newborns with congenital anomalies were included in this study after taking parental consent. All the newborns were assessed by prenatal, natal, and postnatal history, general physical examination, and relevant investigations like ultrasound abdomen, echocardiography, and CT Scan Brain were done; Questionnaire was filled out immediately within 24 hours after hospital admission.
Results: The mean maternal age of the patients was 24.16±4.13 years. Central nervous system (CNS) anomalies were observed in 21% of cases. Neural tube defects like hydrocephalus 6.5%sacrococcygeal teratoma 2.4%, meningomyelocele 11.3%, and encephalocele 0.8%. Cardiovascular system (CVS) anomalies were found in 11.3% cases in which cyanotic 2.4%, (2 were Tetralogy of Fallot and 1 was Transposition of great arteries) Acyanotic 8.9% (10 Ventricular septal defects and 1 atrial septal defect). Gastrointestinal tract (GIT) Anomalies (39.5%) like, duodenal atresia (0.8%), anorectal malformations (25%), Pyloric Stenosis (0.8%), exomphalocele (5.6%), diaphragmatic hernia (2.4%), Hirschsprung disease (4.8%). Genitourinary system abnormalities (16.9%) like Hypospadias (14.5%), undescended testes (0.8%), cloacal exstrophy (0.8%) and hydrometrocolpos (0.8%). Musculoskeletal abnormalities (11.3%) like clubfoot (0.8%), developmental dysplasia of Hip (0.8%), polydactyly (1.6%) and cleft lip & palate (8.1%) of cases.
Conclusion: Congenital abnormalities are prevalent in our setup, and the CNS is the most commonly involved system, followed by the gastrointestinal system, genitourinary system, cardiovascular system, and musculoskeletal system. The prevalence and pattern of congenital defects must be known in order for healthcare providers to create preventive interventions at various levels.
Integrating video and genetic data to estimate annual age‐structured apparent survival of American black bears
Authors: Reynolds‐Hogland Melissa , Ramsey Alan B. , Muench Carly , Pilgrim Kristine L. , Engkjer Cory , Erba Grace , Ramsey Philip W. 
Published: April 2022

AbstractCamera or genetic data are increasingly used to estimate wildlife abundance and density. We integrated video camera data with genetic data over 7 years to estimate annual age‐structured apparent survival of American black bears (Ursus americanus). We identified 70 individuals through meticulous scrutiny of 7531 video captures, cross‐referenced with 721 genetic captures from hair samples concurrently collected from stations in view of cameras. We used the Cormack–Jolly–Seber model in Program Mark to estimate annual age‐structured apparent survival for yearling males, yearling females, 2+ year‐old males, and 2+ year‐old females. We manually calculated cub survival. We compared parameter estimates based on combined video and genetic data with those based on only genetic data. Combining video and genetic data provided a means to test video‐based identification accuracy, which was highest for females (97%–100%). Annual apparent survival was highest for yearling females (φ = 0.92, SE = 0.07), followed by 2+ year‐old females (φ = 0.88, SE = 0.05), 2+ year‐old males (φ = 0.84, SE = 0.06), and yearling males (φ = 0.80, SE = 0.14). Annual cub survival (φ = 0.86, SE = 0.07) was likely biased because we could not account for mortality that occurred in‐den through early spring. Annual apparent survival and recapture probabilities derived from only genetic data were lower than those derived from combined video and genetic data. Our finding that noninvasive data can be used to estimate annual age‐structured apparent survival of a species with relatively indistinct traits is broadly relevant to wildlife research and conservation.
Visualizing Emergent Magnetic Flux of Antiskyrmions in Mn1.4PtSn Magnet
Authors: He Zhidong , Song Dongsheng , Wang Weiwei , Wang Ning , Ge Binghui , Wang Shouguo , Tian Mingliang , Du Haifeng 
Published: April 2022

AbstractTopologically protected spin textures, such as magnetic skyrmions, have attracted considerable attention owing to their emergent electromagnetic phenomena and potential applications in spintronics. The antiskyrmion, a new member of the skyrmion family in the nanoscale dimension, consists of alternating Néel‐ and Bloch‐type boundary walls; it has already been discovered in non‐centrosymmetric magnets with D2d/S4 symmetry. However, its complex spin textures and unique magnetic‐charge‐induced emergent field have not been explicitly visualized thus far. Here, state‐of‐the‐art off‐axis electron holography is employed to directly resolve the antiskyrmions in a non‐centrosymmetric Heusler magnet Mn1.4PtSn with D2d symmetry. The magnetic flux distribution inside and outside the antiskyrmion is clearly imaged, indicating the emergent magnetic field induced by the broken cylindrical symmetry. More importantly, the closed emergent flux between adjacent antiskyrmions is revealed, indicating the antiskyrmion‐antiskyrmion interactions (a different mechanism compared to that of conventional skyrmions). These findings provide a clear and deep insight into the intrinsic magnetic flux configuration in the antiskyrmion‐hosted magnets, thus paving the way for the manipulation of antiskyrmions in the future.
In Situ Nanofluid Dispersion Monitoring by Liquid–Solid Triboelectric Nanogenerator Based on Tuning the Structure of the Electric Double Layer
Authors: Luo Hao , Wang Hanqing , Yang Lijun , Wu Han , Kang Shenglin , Yong Shun , Liao Ruijin , Wang Jiyu , Wang Zhong Lin 
Published: April 2022

AbstractAn agglomeration phenomenon characterized by nanoparticle dispersion is a decisive factor that reflects the degree of the maintained overall performance of nanofluids and other nanocomposites. However, the quantitative characterization and non‐destructive measurement for nanofluid dispersion (NFD) still remain challenged. Herein, an in situ NFD measurement system based on a variable frequency liquid–solid triboelectric nanogenerator (VFLS‐TENG) is developed. This work utilizes VFLS‐TENG as a passive probe and proposes an equivalent capacitance circuit model for detecting NFD based on the electric double layer model at liquid–solid interfaces. In the circuit model, a quantitative calculation process for both particle size and spacing is introduced through parameter identification using the Quantum Genetic and Levenberg–Marquardt hybrid algorithm, and parameter separation using the Runge–Kutta algorithm. The results demonstrates a good agreement with the traditional methods, among which the measured particle size is more accurate than the hydrodynamic diameter of dynamic light scattering by 28.6% with a high sensitivity of 1667 nm nF−1. The proposed method is capable of measuring the effective charge on the nanoparticle surface in situ, and simultaneously obtaining the particle size and spacing for the online monitoring NFD, thus further facilitating the controllable preparation during the nano‐composites modification, and quantitative optimization of nanofluid design performance.
Combinatorial Use of Therapeutic ELP‐Based Micelle Particles in Tissue Engineering
Authors: Bulutoglu Beyza , Acun Aylin , Deng Sarah L. , Mert Safak , Lupon Elise , Lellouch Alexandre G. , Cetrulo Curtis L. , Uygun Basak E. , Yarmush Martin L. 
Published: April 2022

AbstractElastin‐like peptides (ELPs) are a versatile platform for tissue engineering and drug delivery. Here, micelle forming ELP chains are genetically fused to three therapeutic molecules, keratinocyte growth factor (KGF), stromal cell‐derived growth factor 1 (SDF1), and cathelicidin (LL37), to be used in wound healing. Chronic wounds represent a growing problem worldwide. A combinatorial therapy approach targeting different aspects of wound healing would be beneficial, providing a controlled and sustained release of active molecules, while simultaneously protecting these therapeutics from the surrounding harsh wound environment. The results of this study demonstrate that the conjugation of the growth factors KGF and SDF1 and the antimicrobial peptide LL37 to ELPs does not affect the micelle structure and that all three therapeutic moieties retain their bioactivity in vitro. Importantly, when the combination of these micelle ELP nanoparticles are applied to wounds in diabetic mice, over 90 % wound closure is observed, which is significantly higher than when the therapeutics are applied in their naked forms. The application of the nanoparticles designed here is the first report of targeting different aspect of wound healing synergistically.
Socially‐Directed Development of Materials for Structural Color
Authors: Datta Bianca , Spero Ellan F. , Martin‐Martinez Francisco J. , Ortiz Christine 
Published: April 2022

AbstractAdvancing a socially‐directed approach to materials research and development is an imperative to address contemporary challenges and mitigate future detrimental environmental and social impacts. This paper reviews, synergizes, and identifies cross‐disciplinary opportunities at the intersection of materials science and engineering with humanistic social sciences fields. Such integrated knowledge and methodologies foster a contextual understanding of materials technologies embedded within, and impacting broader societal systems, thus informing decision making upstream and throughout the entire research and development process toward more socially responsible outcomes. Technological advances in the development of structural color, which arises due to the incoherent and coherent scattering of micro‐and nanoscale features and possesses a vast design space, are considered in this context. Specific areas of discussion include material culture, narratives, and visual perception, material waste and use, environmental and social life cycle assessment, and stakeholder and community engagement. A case study of the technical and social implications of bio‐based cellulose (as a source for structurally colored products) is provided. Socially‐directed research and development of materials for structural color hold significant capacity for improved planetary and societal impact across industries such as aerospace, consumer products, displays and sensors, paints and dyes, and food and agriculture.