bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Qualitative Meta-synthesis of the Post-Traumatic Growth Experiences among Female Breast Cancer Patients and Survivors
Authors: He Longtao , Wu Han , Jean Jason Allan , Lyu Jianxia , Li Menghua , Zhang Nike , Liu Jiamin , Zhou Chenyan 
Published: August 2022

Abstract
Objective: Female breast cancer patients do not only experience trauma, but also positive growth. Yet, there has been few qualitative reviews. This study aims to synthesize the results of relevant qualitative studies to comprehensively interpret the PTG experiences of female breast cancer patients.Methods: We utilized the qualitative meta-synthesis approach including literature search, quality evaluation, data abstraction, and data synthesis.Results: Forty English studies and four Chinese studies were included in the final analysis. The PTG experiences among female breast cancer patients and survivors are summarized into five primary themes in line with the PTGI tool: personal strength, new possibilities, growth relating to others, appreciation of life, as well as spiritual and existential changes. Their subthemes expanded the meanings of three principle themes in the PTGI tool: personal strength (the addition of a sub-theme “better emotional control”), appreciation and change of life (the addition of a sub-theme “new health awareness/behavior”), and spiritual and existential change (the addition of a sub-theme “more willing to explore spiritual activities”). Conclusion: A gendered nature and cultural feature were identified from these expanded themes. Additionally, we also identified that the importance of family members over the patients’ PTG experiences as being cross-cultural. Implication for Cancer Survivors: Our results can enlighten a multidisciplinary team of health professionals, to provide tailored interventions to facilitate PTG experiences of female breast cancer patients.
Representation of soil hydrology in permafrost regions may explain large part of inter-model spread in simulated Arctic and subarctic climate
Authors: de Vrese Philipp , Georgievski Goran , Rouco Jesus Fidel Gonzalez , Notz Dirk , Stacke Tobias , Steinert Norman Julius , Wilkenskjeld Stiig , Brovkin Victor 
Published: August 2022

Abstract
The current generation of Earth system models exhibits large inter-model differences in the simulated climate of the Arctic and subarctic zone, with differences in model structure and parametrizations being one of the main sources of uncertainty. One particularly challenging aspect in modelling is the representation of terrestrial processes in permafrost-affected regions, which are often governed by spatial heterogeneity far below the resolution of the models' land surface components. Here, we use the MPI Earth System model to investigate how different plausible assumptions for the representation of the permafrost hydrology modulate the land-atmosphere interactions and how the resulting feedbacks affect not only the regional and global climate, but also our ability to predict whether the high latitudes will become wetter or drier in a warmer future. Focusing on two idealized setups that induce comparatively "wet" or "dry" conditions in regions that are presently affected by permafrost, we find that the parameter settings determine the direction of the 21stcentury trend in the simulated soil water content and result in substantial differences in the land-atmosphere exchange of energy and moisture. The latter leads to differences in the simulated cloud cover and thus in the planetary energy uptake. The respective effects are so pronounced that uncertainties in the representation of the Arctic hydrological cycle can help to explain a large fraction of the inter-model spread in regional surface temperatures and precipitation. Furthermore, they affect a range of components of the Earth system as far to the south as the tropics. With both setups being similarly plausible, our findings highlight the need for more observational constraints on the permafrost hydrology to reduce the inter-model spread in Arctic climate projections.
Transcriptional landscapes and signaling pathways of LDHA inhibitor treated pancreatic ductal adenocarcinoma
Authors: Chang Tingxiang , Qian Zhiwen 
Published: August 2022

Abstract
Lactate dehydrogenase (LDHA) is a metabolism-related enzyme that is involved in the progression of several cancers such as pancreatic ductal adenocarcinoma (PDAC). However, the mechanism of LDHA regulates the PDAC is largely unknown. In this study, we analyzed the RNA-seq data of LDHA inhibitor-treated PDAC cells and identified the transcriptional landscapes of these cells. We used the gene enrichment assays including KEGG and GO to further analyzed the potential signaling pathways. In addition, we constructed the PPI network and Reactome map to further identified the biological processes. We found the TNF signaling pathway and Cellular senescence are the major signaling pathways that involve the LDHA inhibitor-treated PDAC cells. We identified the top ten interactive genes including FN1, CCND1, HDAC1, NFKBIA, PPARG, HSPA5, AURKB, CXCR4, RUNX2, and IRF1. Our study may provide novel mechanisms for the treatment of PDAC.
Impacts of climate change on crop and irrigation water requirement in the Savannah regions of Ghana
Authors: Incoom Awo Boatemaa Manson , Adjei Kwaku Amaning , Odai Samuel Nii , Akpoti Komlavi , Siabi Ebenezer Kwadwo 
Published: August 2022

Abstract
Irrigation is important for food security, however, water requirements for sustainable irrigation may be affected by climate change. The study analysed water requirements of two commonly cultivated crops in the dry season in the Ghanaian Savannah regions under baseline and future periods. Crop water requirement (CWR) and crop irrigation requirement (CIR) were lowest in baseline periods and increased in the 2020s, 2050s, and 2080s for RCP 4.5 and RCP 8.5 at all locations. CIR was higher for tomato as compared to onions for most locations. Seasonal changes in the CWR ranged from 2–9, 3–12, and 3–12% and 2–8 3–12% and 5–18% for the 2020s, 2050s and 2080s under RCP 4.5 and RCP 8.5, respectively, for both the crops. Bole and Zuarungu recorded highest increases in CWR for tomato, whereas the least change was observed at Yendi for onions. Changes in seasonal CIR ranged from 3–19, 2–21, and 6–22%, respectively, for the 2020s, 2050s and 2080s for RCP 4.5. Under RCP 8.5, changes in seasonal CIR ranged from 3–23, 5–23, and 6–27% were observed for the 2020s, 2050s, and 2080s, respectively. Highest increases in CIR were noticed at Bole and Zuarungu for tomato, whereas the least change was observed at Wenchi for onions. Findings of the study support zero hunger and climate action, goals 2 and 13 of the Sustainable Development Goals (SDGs).
HIGHLIGHTS The study analysed water requirements of two commonly cultivated crops in the dry season in the Savannah regions of Ghana. Crop and irrigation water requirements were generally lowest in baseline periods and increased in the 2020s, 2050s, and 2080s under RCP 4.5 and RCP 8.5. Highest increases in irrigation requirement were noticed at Bole and Zuarungu for tomato, whereas the least change was observed at Wenchi for onions.
Nanosponges-based Drug Delivery System for the Cosmeceutical Applications
of Stabilized Ascorbic Acid
Authors: Zuberi Sadia Ahmed , Sheraz Muhammad Ali , Ali Syed Abid , Shah Muhammad Raza , Mujahid Sumbul , Ahmed Sofia , Anwar Zubair 
Published: August 2022

Background:
L-Ascorbic acid (AA) is a highly unstable compound, thus, limiting its use in
pharmaceutical and cosmetic products, particularly at higher concentrations.

Objective:
This study aimed to stabilize the highly sensitive molecule (AA) by encapsulating it in β-
cyclodextrin nanosponges (β-CD NS) that can be used further in preparing cosmeceuticals products
with higher AA concentrations and enhanced stability.

Methods:
The NS has been synthesized by the melting method. The AA was encapsulated in β-CD NS
by the freeze-drying process. The prepared NS were characterized by FTIR spectrometry, SEM, Atomic
Force Microscopy (AFM), zeta sizer, Differential Scanning Calorimetry (DSC), and the physical flow
characteristics were also studied. The in vitro drug release was carried out on the Franz apparatus using
a combination of two methods: sample & separate and dialysis membrane. The assay was performed
using a validated spectrometric method.

Results:
The entrapment efficiency of AA in β-CD NS indicated a good loading capacity (83.57±6.35%).
The FTIR, SEM, AFM, and DSC results confirmed the encapsulation of AA in β-CD NS. The particle
size, polydispersity index, and zeta potential results ascertained the formation of stabilized monodisperse
nanoparticles. The physical flow characteristics showed good flow properties. Around 84% AA
has been released from the NS in 4 h following the Korsmeyer-Peppas model. The AA-loaded NS remained
stable for nine months when stored at 30±2°C/65±5% RH.

Conclusion:
It is concluded that the prepared NS can protect the highly sensitive AA from degradation
and provide an extended-release of the vitamin. The prepared AA-loaded β-CD NS can be used to formulate
other cosmeceutical dosage forms with better stability and effect.
FA-HA-Amygdalin@Fe2O3 and/or γ-Rays Affecting SIRT1 Regulation of
YAP/TAZ-p53 Signaling and Modulates Tumorigenicity of MDA-MB231
or MCF-7 Cancer Cells
Authors: Abdel-Rafei Mohamed K. , Azab Khaled S. , El-Sayyad Gharieb S. , Askar Moustafa A. , El Kodous Mohamed Abd , El Fatih Neama M. , Tawill Ghada El , Thabet Noura M. 
Published: August 2022

Background:
Breast cancer (BC) has a complex and heterogeneous etiology, and the emergence of resistance to conventional chemo-and radiotherapy results in unsatisfactory outcomes during BC treatment. Targeted nanomedicines have tremendous therapeutic potential in BC treatment over their free drug counterparts.

Objective:
Hence, this study aimed to evaluate the newly fabricated pH-sensitive multifunctional FA-HA-Amygdalin@Fe2O3 nano-core-shell composite (AF nanocomposite) and/or γ-radiation for effective localized BC therapy.

Methods:
Methods: The physicochemical properties of nanoparticles were examined, including stability, selectivity, responsive release to pH, cellular uptake, and anticancer efficacy. MCF-7 and MDA-MB-231 cells were treated with AF at the determined IC50 doses and/or exposed to γ- irradiation (RT) or were kept untreated as controls. The antitumor efficacy of AF was proposed via assessing anti-proliferative effects, cell cycle distribution, apoptosis, and determination of the oncogenic effectors.

Results:
Results: In a bio-relevant medium, AF nanoparticles demonstrated extended-release characteristics that were amenable to acidic pH and showed apparent selectivity towards BC cells. The bioassays revealed that the HA and FA-functionalized AF markedly hindered cancer cell growth and enhanced radiotherapy (RT) through inducing cell cycle arrest (pre-G1 and G2/M) and increasing apoptosis, as well as reducing the tumorigenicity of BCs by inhibiting Silent information regulation factor 1 (SIRT1) and restoring p53 expression, deactivating the Yes-associated protein (YAP)/ Transcriptional coactivator with PDZ-binding motif (TAZ) signaling axis, and interfering with the tumor growth factor- β(TGF- β)/SMAD3 and HIF-1α/VEGF signaling hub while up-regulating SMAD7 protein expression.

Conclusions:
Collectively, the novel AF alone or prior RT abrogated BC tumorigenicity.
Cytotoxicity Effects of Miltefosine and Niosomal form on Human Umbilical
Vein Endothelial Cells: Colorimetric Assay, Apoptosis, and Gene Expression
Profiling
Authors: Sharifi Fatemeh , Seyedi Fatemeh , Mohamadi Neda , Sharifi Iraj , Pardakhty Abbas , Khosravi Ahmad , Kamali Ali 
Published: August 2022

Background:
Miltefosine (MIL), hexadecyl phosphocholine, is the only oral medicine used to
treat leishmaniasis. This drug has a major limitation and is expensive and potentially teratogenic. Objective:
This study aimed to evaluate the toxic effect of MIL and its niosomal form on human umbilical vein
endothelial cells (HUVECs), the expression genes, and the profile associated with apoptosis in the mitochondrial
permeabilization regulated.

Methods:
Miltefosine niosome (MN) prepared by the thin-film hydration method and characterized. HUVECs
were treated with MIL (100–1000μg/ml), and MN (10-50μg/ml) for 24, 48, and 72 h, and the persistence
was assessed by colorimetric assay flow cytometry and real-time PCR.

Results:
Lesser toxicity was detected on cell proliferation for MN while both forms decreased Bcl-2 and
elevated the expression of Bak/Bax and caspases-3, -8, and -9. The data demonstrated that MIL significantly
exerted its cytotoxicity on HUVECs compared to MN.

Conclusion:
This drug should be considered embryotoxic during pregnancy, while in niosomal form, it
released slowly and remained safe. The mechanism of action of MIL associated with programmed cell
death.
Tandem Mass Analysis of Amino Acids and Acylcarnitine Profiles in Neonates
with Congenital Hypothyroidism
Authors: Lotfi Jabar , Taghikhani Mohammad , Rabbani Ali , Khatami Shohreh , Rasaee Mohammad Javad 
Published: August 2022

Background:
Congenital hypothyroidism (CH) is the most common neonatal endocrine
disorder. This study aimed to investigate whether disturbances in amino acid metabolism and fatty
acid oxidation existed in neonates with CH compared to healthy neonates.

Methods:
In this case-control study, we evaluated the metabolomics of neonates with newly diagnosed
CH and healthy neonates. Forty-three metabolites, including 13 amino acids and 30 acylcarnitines,
were investigated.

Results:
Two hundred neonates with CH and 209 healthy children were enrolled. The mean age of
males and females was 4.8 ± 2.4 and 5.52 ± 3.2 days in the case group and 5.1 ± 2.6 and 4.7 ± 3.6
days in the control group, respectively. Of the metabolites, 34 were significantly different between
the two groups. Five amino acids and four acylcarnitines did not differ significantly between groups.

Conclusion:
These findings pave the way for a better understanding of the relationship between
alterations and the clinical manifestation of CH, which has the potential for identifying novel therapeutics.
Additive technology for manufacturing products and structures from reinforced concrete
Authors: Nakhaev M. R. 
Published: August 2022

Objective. An analysis of already known technological methods for molding shotcrete and a construction 3D printer confirmed the effectiveness of building additive technologies. The proposed extended additive technology, the method of electrostatic molding of products and structures made of reinforced concrete, will find its practical application in construction.Method. The principle of obtaining electrostatic concrete is the electrostatic deposition of a semi-dry mixture of binder, finely ground sand and fibers on a shaping base made of steel or carbon mesh. The resulting layers are dosed with finely sprayed water with various additives, the mixture sedimentation and moisturizing cycles are repeated until the desired thickness of reinforced concrete is obtained.Result. Electrostatic buildup of concrete layers occurs without mechanical impact on the shaping base. This means that the basis of the product can be made from a small amount of material in a short time and in any available way. The first layers of fiber-reinforced concrete, after holding time, give strength to the shaping base. As the thickness of concrete increases, the strength of the product increases, outstripping the increase in mass.Conclusion. The electrostatic molding method makes it possible to manufacture thin-walled body parts of complex shape, spatial shells, architectural and construction parts, and structures of membranes, hollow columns and racks, power line supports, reclamation gutters, large-diameter drainage pipes, tanks, etc.
To the question of analysis of existing methods of access of regular users to information resources of automated systems of internal affairs bodies
Authors: Wolf V. A. , Nasedkina V. S. , Popov A. D. , Rogozin E. A. , Khvostov V. A. 
Published: August 2022

Objective. Currently, access to the information resource of the ATS AS is implemented through the access control subsystem of the information security facility based on the mandatory and discretionary methods of access control developed in the 70s of the last century and requiring improvement. The purpose of the study is to analyze existing methods and, on this basis, select the optimal method for regular users to access information resources of automated systems of internal affairs bodies.Method. System analysis, graph theory method, and verbal (verbal) modeling.Result. A new aspect of the method of access of regular users to information resources of automated ATS systems, based on the use of hierarchical metrics of semantic proximity, is disclosed.Conclusion. The use of a method based on semantic proximity significantly reduces the processing of a large amount of information, respectively, increasing the performance of automated systems.
Determination of seismic wave velocities on the ground using artificial neural networks
Authors: Sidorkina Yu. A. , Aslanov T. G. , Magomedov H. D. 
Published: August 2022

Objective. The purpose of the study is to determine the velocities of seismic waves on the ground.Method. To determine the velocities of seismic waves in different parts of the earth's crust, using a sample obtained by mathematical modeling, an artificial neural network was trained. Using at the input of the trained neural network, the real values of the differences in the times of arrival of seismic waves on the ground, we obtain at its output the values of the velocities of seismic waves on the ground.Result. A method for determining the velocities of seismic waves on the ground using artificial neural networks is proposed. Dependences of the root-mean-square error in determining the velocities of seismic waves on the ground on the training epoch, as well as the distribution of errors in determining the coordinates of the earthquake hypocenter using the obtained information about the structure of the earth, are obtained.Conclusion. The proposed method makes it possible to determine the structure of the earth's crust more accurately than previously proposed mathematical methods.
Method for constructing a CAD training course
Authors: Hoang C.K. 
Published: August 2022

Objective. In the development of the electronic industry, one of the strategic directions for the development of organizations is personnel training. The costs of training and the implementation of training courses in the context of the COVID-19 pandemic are significant. The purpose of this work is to increase the efficiency of engineers' activities in computer-aided modular design systems based on printed circuit boards (PCB) through the formation of the necessary competencies and recommendations for the designer.Method. The article provides an overview of methods and systems for the formation of CAD content in various industries. It is proposed to create a training system updated in real time, which will improve the skills of engineers and overcome gaps in production The structure of an automated learning system (AOS) is developed. What makes this structure different from others is an ontological model domain and an adaptive model. An adaptive method has been developed for constructing a CAD training course for enterprises in the instrument manufacturing industry, which is distinguished by the use of mechanisms for the interaction of learning models. The individual characteristics of the engineer being trained to form an adaptive learning scenario are taken into account in these learning models. This allows providing the optimal learning trajectory to the student with a reduction in learning time.Result. This research method is used to improve the skills of engineers in the course "Design of modules based on PP" at the X52 shipyard in Vietnam. As the results of the experiments, we can achieve a result that this effective method increases the level of engineering competence by 11.3% and decreases the total training time by 25.4 % compared to +the traditional method. Moreover, this method also reduces the cost of additional training for new engineers.Conclusion. The obtained results demonstrate the need to develop an adaptive training system. Thank to this method, the competency of the software-based modular design engineers will be developed. The adequacy of this method has been previously confirmed by the experimental data and the previous studies.
Longitudinal vibrations of rods from dynamic and kinematic perturbations
Authors: Baragunova L. A. , Shogenova M. M. 
Published: August 2022

Objective. In modern technology, elastic structures of structures, machines, and technical devices are widespread. In real conditions, the rods experience oscillations from dynamic and kinematic disturbances. The aim of the work is to develop methods and algorithms for solving problems of oscillations under dynamic and kinematic disturbances.Method. The study is based on the application of the hypothesis of flat sections and the d'Alembert principle.Result. The problem of longitudinal free and forced vibrations of rods is considered. As a result, the displacement function of transverse sections in the longitudinal direction of the rod was found, the spectra of natural forms jn and natural frequencies wn of vibrations were obtained.Conclusion. A set of calculation programs has been created, which makes it possible to solve problems of rod vibrations. Spectra of eigenfrequencies wn and eigenmodes jn(x) of vibrations are obtained, and u(x, t) is found, the function of displacement of cross sections in the longitudinal direction of the rod.
Calculation model of thermoelectric system for cooling discrete semiconductor devices
Authors: Evdulov O. V. , Ibragimova A. M. , Magomedov T. Yu. 
Published: August 2022

Objective. The aim of the study is to develop a computational model of a thermoelectric system (TPS) for cooling discrete semiconductor devices (DSD), implemented in the Elcut application software package, and to conduct a corresponding numerical experiment on it.Method. A new type of DPP cooling system has been developed, which uses several TEM sections that provide heat removal from both the lower and upper surfaces of the fuel elements, which increases the heat exchange surface between the cold source and the REE element and increases the heat removal efficiency. Using the finite element method, a computational model of this system is constructed based on the solution of the problem of thermal conductivity for a multi-element structure of a complex configuration, each component of which is characterized by thermal and electrical parameters.Result. A numerical experiment was carried out using the calculation model. As a result of it, the results of a numerical experiment were obtained in the form of a three-dimensional picture of the temperature field of the DPP - TPP system when it reaches the stationary mode, as well as graphs of temperature changes over time in the center of discrete semiconductor devices at various values of the cooling capacity of the thermoelectric module (TEM).Conclusion. As a result of the numerical experiment, it was found that the proposed design of the cooling TPP fully allows solving the problem of ensuring the required temperature regime of the DPP in the range of its power up to 75 W. At the same time, the use of sections of thermoelectric modules from thermoelements identical in their geometric, electrical and thermal characteristics makes it possible to increase the manufacturability of the device, as well as to ensure its operation in optimal current modes.