bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a single‐run liquid chromatography‐mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
Authors: Razak Muhammad Raznisyafiq , Aris Ahmad Zaharin , Sukatis Fahren Fazzer , Zaki Muhammad Rozaimi Mohd , Zainuddin Azim Haziq , Haron Didi Erwandi Mohamad , Yusoff Fatimah Md , Yusof Zetty Norhana Balia 
Published: November 2022

In toxicological analysis, the analytical validation method is important to assess the exact risk of contaminants of emerging concern in the environment. Syringe filters are mainly used to remove impurities from sample solutions. However, the loss of analyte to the syringe filter could be considerable, causing an underestimate of the analyte concentrations. The current study develops and validates simultaneous liquid chromatography‐mass spectrometry analysis using a direct filtration method to detect four groups of contaminants of emerging concern. The adsorption of the analyte onto three different matrices and six types of syringe filters is reported. The lowest adsorption of analytes was observed in methanol (16.72%), followed by deionized water (48.19%) and filtered surface lake water (48.94%). Irrespective of the type of the matrices, the lowest average adsorption by the syringe filter was observed in the 0.45 μm polypropylene membrane (15.15%), followed by the 0.20 μm polypropylene membrane (16.10%), the 0.20 μm regenerated cellulose (16.15%), the 0.20 μm polytetrafluoroethylene membrane (47.38%), the 0.45 μm nylon membrane (64.87%) and the 0.20 μm nylon membrane (71.30%). In conclusion, the recommended syringe filter membranes for contaminants of emerging concern analysis are polypropylene membranes and regenerated cellulose, regardless of the matrix used.
Exploring the relevance of Social Exchange Theory in the Middle East: A case study of tourism in Dubai, UAE
Authors: Dutt Christopher S. , Harvey William S. , Shaw Gareth 
Published: November 2022

AbstractWhilst numerous studies have explored residents' perceptions of tourism, there are three significant gaps with Social Exchange Theory (SET). First, the appropriateness and generalisability; second, the heterogeneity of host population perceptions; third, perceptions in non‐Western empirical contexts. A mixed methods study was conducted, using 36 face‐to‐face interviews with expatriates and nationals in Dubai to develop a survey instrument which returned over 400 responses. Results show that whilst SET is appropriate and partially generalisable, substantial adjustments are required to account for external factors such as culture and the political environment. We propose a new theory of Tourism Returns and Moderators to show a more holistic outcome, weighted perceptions, varying moderators, and greater individualised focus. In this study, participants had a preference to support tourism, did not refer to a cost‐benefit trade‐off, and generally favoured economic benefits over others.
An archive of Lake Superior temperature and current measurements, 2005–2020
Authors: Austin Jay , Elmer Cassandra 
Published: November 2022

AbstractSince 2005, investigators at the University of Minnesota, Duluth's Large Lakes Observatory have been maintaining subsurface moorings and surface buoys in Lake Superior to study thermal structure and currents throughout the water column and throughout the year. A single site has been continuously occupied for over 17 years as of the writing of this manuscript, another 10 sites have been occupied for multiple years, and for 3 months in summer 2017 an intensive field campaign occupied 12 sites simultaneously in western Lake Superior. All of these data are available on a publicly accessible archival site hosted by the University of Minnesota.
Nutlin‐3 acts as a DNA methyltransferase inhibitor to sensitize esophageal cancer to chemoradiation
Authors: Chang Wei‐Lun , Hsieh Chih‐Hsiung , Kuo I‐Ying , Lin Chien‐Hsun , Huang Yu‐Lin , Wang Yi‐Ching 
Published: November 2022

AbstractEsophageal squamous cell carcinoma (ESCC) is highly resistant to chemoradiation therapy. We aimed to examine whether Nutlin‐3, a molecule that suppresses murine double min 2 (MDM2)‐mediated p53 and Retinoblastoma (RB) protein degradation leading to downregulation of DNA methyltransferases (DNMTs), can be a novel therapeutic agent for ESCC. We used wild‐type and chemoradiation‐resistant ESCC cell lines in this study. The expression of DNMTs, p53 and RB, and methylation level of tumor suppressor genes (TSG) were analyzed upon Nutlin‐3 treatment. The antitumor efficacy of Nutlin‐3 was investigated in ESCC cell lines and xenograft tumor model. TSG protein expression was checked in the excised tumor tissue. Nutlin‐3 induced upregulation of p53 and RB and downregulation of DNMTs proteins in the chemoradiation‐resistant and aggressive ESCC cells. The methylation level of TSGs was decreased by Nutlin‐3. Nutlin‐3 inhibits clonogenic growth of ESCC cells and exerts a synergistic cytotoxic‐effect when combined with chemotherapeutic agent cisplatin. Moreover, xenograft tumor growth in SCID mice was suppressed by Nutlin‐3. The protein expression level of DNMTs was downregulated, and that of TSGs was upregulated by Nutlin‐3 treatment in the excised tumor tissue. In conclusion, Nutlin‐3 is a potential therapeutic agent that can potentiate the treatment efficacy of chemoradiation‐resistant ESCC.
Dihydroartemisinin synergistically enhances the cytotoxic effects of oxaliplatin in colon cancer by targeting the PHB2‐RCHY1 mediated signaling pathway
Authors: Wang Xiwei , Zheng Yingying , Chai Zhengbin , Li Ji , Zhu Changhui , Peng Yanling , Qiu Juanjuan , Xu Jiajun , Liu Chunyan 
Published: November 2022

AbstractDihydroartemisinin (DHA) has recently attracted increasing attention for its low toxicity and high antitumor activity. DHA has been reported to have synergistic anticancer effects with a variety of drugs in the clinic; however, the molecular mechanism by which DHA inhibits tumorigenesis and improves oxaliplatin cytotoxicity in colon cancer cells is still not well understood. In this study, we found that DHA can inhibit cell proliferation and colony formation in a dose‐dependent manner. Prohibitin 2 (PHB2) is a potential target by which DHA exerts its antitumor and cytotoxic effects. The function and molecular mechanism of PHB2 in colon cancer tumorigenesis were fully studied to determine the regulatory mechanism between DHA and PHB2. We found that PHB2, a mitochondrial inner membrane scaffold protein, has a higher expression level in colon cancer tissues than in adjacent nontumor tissues and is mainly localized in mitochondria. Overexpression of PHB2 can promote cell proliferation and colony formation in vitro and accelerate tumor growth in vivo. We also found that the expression level of PHB2 was inversely related to the cytotoxicity of DHA and oxaliplatin in colon cancer cells. The molecular mechanism of PHB2 in tumorigenesis and cancer therapy was further studied. The results showed that 20 μM DHA can downregulate PHB2 expression in a ubiquitylation‐dependent manner and subsequently block PHB2‐induced RCHY1 upregulation and p53 and p21 downregulation. In this process, RCHY1 is necessary for PHB2 to play a tumor‐promoting role. Thus, PHB2 and RCHY1 are effective targets for colon cancer therapy, and DHA has synergistic anticancer effects with oxaliplatin via promoting PHB2 degradation in colon cancer cells.
Arginase 1 Deficiency in Patients Initially Diagnosed with Hereditary Spastic Paraplegia
Authors: McNutt Markey C. , Foreman Nathan , Gotway Garrett 
Published: November 2022

AbstractBackgroundArginase 1 Deficiency (ARG1‐D) is a rare autosomal recessive urea cycle disorder (UCD) characterized by pathologic elevation of plasma arginine and debilitating manifestations. Based on clinical commonalities and low disease awareness, ARG1‐D can be diagnosed as hereditary spastic paraplegia (HSP), leading to treatment delays.CasesA Hispanic woman with unremarkable medical history experienced progressive lower‐limb spasticity in her 20s and received a diagnosis of HSP. She developed significant gait abnormalities and is unable to walk without assistance. More recently, two Hispanic brothers with childhood‐onset manifestations including lower‐limb spasticity, developmental delays, and seizures presented with suspected HSP. All three patients were ultimately diagnosed with ARG1‐D based on plasma arginine several‐fold above normal levels and loss‐of‐function ARG1 variants. Disease progression occurred before ARG1‐D was correctly diagnosed.Literature ReviewRetrospective analyses demonstrate that diagnostic delays in ARG1‐D are common and can be lengthy. Because of clinical similarities between ARG1‐D and HSP, such as insidious onset and progressive spasticity, accurate diagnosis of ARG1‐D is challenging. Timely ARG1‐D diagnosis is critical because this UCD is a treatable genetic cause of progressive lower‐limb spasticity.ConclusionsArginase 1 Deficiency should be considered in HSP differential diagnosis until biochemically/genetically excluded, and should be routinely included in HSP gene panels.
Identification of genetic characteristics in pediatric epilepsy with focal cortical dysplasia type 2 using deep whole‐exome sequencing
Authors: Xu Yan , Zhao Rui , Wang Min , Wang Xin‐hua , Wang Yi , Li Hao , Ma Yang‐yang , Wu Bing‐bing , Zhou Yuan‐feng 
Published: November 2022

AbstractBackgroundFocal cortical dysplasia type 2 (FCD2) is a malformation of cortical development that constitutes a common cause of pediatric focal epilepsy. Germline or somatic variants in the mammalian target of rapamycin (mTOR) signaling pathway genes are the pathogenesis of FCD2.ObjectiveIn this study, whole‐exome deep sequencing was performed on dysplastic cortex from focal epilepsy in children to explore genetic characteristics in FCD2.MethodsResected core lesions of FCD2 were confirmed by pathology, and peripheral blood was collected from 11 patients. Deep whole‐exome sequencing (>500X) was performed on derived genomic DNA, germline, or somatic variants in brain‐specific genes were analyzed and identified.ResultsIn 11 patients, a heterozygous likely pathogenic germline variant of DEPDC5 was identified in one case, while somatic variants were found in four brain samples. The frequencies of the somatic variant allele were 2.52%–5.12%. Somatic variants in AKT3, TSC2, and MTOR (mTOR signaling pathway genes) were found in three samples. Besides, one somatic variant was detected in MED12 which has not been reported to associate with FCD2.ConclusionOur study expanded the variant spectrum in the mTOR‐GATOR pathway, and also detected a somatic variant in MED12 which was potentially associated with FCD 2.
Wideband miniaturized antipodal Vivaldi antenna
Authors: Gao Ping , Li Teng , Han Min , Dou Wenbin 
Published: November 2022

AbstractA wideband Vivaldi antenna with a miniaturized size is designed in this letter. The resistive loading, slot‐loading, and coupling line at the radiation arms are introduced to miniaturize the antipodal Vivaldi antenna, as well as further reduce the lowest operating frequency. To verify the proposed design, a prototype with the size of 132 mm × 161 mm × 0.508 mm is fabricated. The measured results, which agree well with the simulations, show that an impedance bandwidth from 0.4 to 4 GHz with |S11| < −10 dB is realized, and the gain of the antenna varies between −7 and 7.5 dBi.
An FSS structure with a band‐stop performance for UWB applications
Authors: Sondas Adnan 
Published: November 2022

AbstractIn this paper, a frequency selective surface (FSS) structure with a band‐stop performance for ultra‐wideband (UWB) applications is introduced. The unit cell of the FSS structure consists of a combination of a square loop, a ring loop, and a cross dipole with four gaps. The unit cell has 0.115λg × 0.115λg size where λg is the wavelength in the substrate corresponding to the minimum frequency (2.79 GHz) of the operating band. The bandwidth of the FSS design is from 2.79 to 10.81 GHz frequencies (at normal incidence and |S21| < −3 dB criterion) which covers all UWB bands. The introduced FSS structure has angular stability up to 80° incident angles both TM and TE polarizations due to the small size of the unit cell. The highest resonance frequency deviation is 0.08% at 80° and this value is quite low. The proposed FSS structure was fabricated and the results obtained through simulations were supported by the measurement results.
Summary and overview of the first ISMRM workshop on magnetic resonance elastography, August 25–26, 2022, Berlin, Germany
Authors: Guo Jing , Marticorena Garcia Stephan , Sack Ingolf 
Published: November 2022

AbstractAn ISMRM workshop on MR elastography was held at Charité–Universitätsmedizin Berlin on August 25–26, 2022. As an exclusively in‐person event, 65 participants from 9 countries attended the workshop despite COVID‐19–related restrictions. The topics of the workshop covered cellular and microtissue mechanical interactions, the development of MR elastography driver technology, approaches to inverse problems, clinical applications, and integration of MR elastography into multiparametric MRI protocols. The workshop was a great success by promoting direct knowledge exchange as well as for strategizing future directions for MR elastography. In this symposium review, we briefly summarized all oral presentations as well as the concluding panel discussion.
An educational programme based on salutogenesis theory on childbirth fear and delivery method among nulliparous women: A mixed methods research protocol
Authors: Kananikandeh Safieh , Shokravi Farkhondeh Amin , Mirghafourvand Mojgan , Jahanfar Shayesteh 
Published: November 2022

AbstractAimDesigning, executing and testing a training intervention based on enhanced concepts of salutogenesis theory for managing fear of childbirth and choice of delivery method among nulliparous women.DesignA Sequential‐Exploratory Mixed Methods Research.MethodsIn the first phase (qualitative approach), the determinants of childbirth fear among nulliparous women will be explored. In the second phase (systematic review), the factors of childbirth fear among them will be summarized. In the third phase, the content of the educational intervention is developed based on the common factors of childbirth fear obtained from the previous two phases of the study. In the fourth phase (randomized controlled trial), two intervention and the control groups will be compared based on primary and secondary outcomes.DiscussionUsing salutogenesis theory in a few interventional studies on various health areas has produced promising results. Based on the evidence, women had less sense of coherence with a strong childbirth fear. Therefore, developing an effective intervention based on this theory can probably help manage childbirth fear and reduce the costs of any potential consequences.
Home care professionals' experiences of successful implementation, use and competence needs of robot for medication management in Finland
Authors: Turjamaa Riitta , Vaismoradi Mojtaba , Kajander‐Unkuri Satu , Kangasniemi Mari 
Published: November 2022

AbstractAimTo describe home care professionals' individual experiences of the implementation, use and competence needs of a robot for medication management in older people's home care.DesignA qualitative focus group interview study.MethodsData were collected during spring and autumn 2021 by semi‐structured focus group interviews and analysed using inductive content analysis. The participants were 62 home care professionals working in older people's home care.ResultsThe successful implementation and use of the robot for medication management consisted of a timely and adequate introduction before the implementation of the robot, the fluent usability of the robot in daily work, and confidence in work competence. There is a need for the reorganization of home care professionals' use of digital solutions to make workflow fluent, prevent burnout and turnover among home care professionals. Professionals' competence should also be developed to ensure that it corresponds to digitalized healthcare.Patient and Public ContributionsNo patient or public contribution.
The use of keywords in archaeornithology literature
Authors: Dirrigl Frank J. , White Justin 
Published: November 2022

AbstractA keyword reflects the subject matter of a journal article that is chosen by its author(s). The selection of keywords by researchers in their works is crucial to disseminating knowledge, increasing publication citations, and advancing a science career. We examined keywords chosen in the titles and keyword sections of the archaeornithology literature generated by past meetings of the Bird Working Group (BWG), International Council for Archaeozoology. We report our results to (1) identify keywords that have been shared across authors, (2) make suggestions to improve showcasing researchers' works, and (3) heighten the importance of keyword choice. Additionally, we propose that the BWG and its members consider recommending a keyword scheme for use in future publications.
Bronchoscopy for removal of foreign body: What's the big deal?
Authors: McCormick Megan Rodgers , Chedid Celine , Shah Jay , Lobas Jeffrey , Rubin Kasia 
Published: November 2022

AbstractForeign bodies of the airway are common occurrences in the pediatric population. Children requiring anesthesia for removal of airway foreign bodies can present many challenges. In this case, the patient required urgent removal of a foreign body while symptomatic with upper and lower respiratory symptoms. Circumstances such as these can result in higher intraoperative and postoperative complications. This presentation describes the clinical decision‐making process and the discussion of common modalities for diagnosis, treatment, and anesthetic management.
Effect of positive surgical margins at radical prostatectomy on cancer‐specific mortality in high/very high‐risk prostate cancer patients with Gleason Grade Group 4–5
Authors: Panunzio Andrea , Sorce Gabriele , Hoeh Benedikt , Hohenhorst Lukas , Tappero Stefano , Nimer Nancy , Rajwa Pawel , Tian Zhe , Terrone Carlo , Chun Felix K. H. , Briganti Alberto , Saad Fred , Shariat Shahrokh F. , Cerruto Maria Angela , Antonelli Alessandro , Karakiewicz Pierre I. 
Published: November 2022

AbstractBackgroundThe effect of positive surgical margins (PSM) on cancer specific mortality (CSM) in high/very high‐risk (HR/VHR) prostate cancer (PCa) with aggressive Gleason Grade Group (GGG) is unknown. We tested PSM effect on CSM in this setting, in addition to testing of radiotherapy (RT) benefit in PSM patients.MethodsWe relied on Surveillance, Epidemiology, and End Results database (2010–2015), focusing on HR/VHR patients with exclusive GGG 4–5 at radical prostatectomy (RP). Kaplan–Meier plots and multivariable Cox regression models tested the relationship between PSM and CSM. Moreover, the effect of RT on CSM was explored in PSM patients.ResultsOf 3383 HR/VHR patients, 15.1% (n = 511) exhibited PSM. Patients with PSM harbored higher rates of GGG 5 (60.1% vs. 50.9%, p < 0.001), pathologic tumor stage T3a (69.1% vs. 45.2%, p < 0.001) and lymph node involvement (14.1% vs. 9.4%, p < 0.001), relative to patients without PSM. PSM rates decreased over time (2010–2015) from 16.0% to 13.6%. Seven‐year CSM‐free survival rates were 91.6% versus 95.7% in patients with and without PSM, respectively. In multivariable Cox regression models, PSM was an independent predictor of CSM (hazard ratio = 1.6, p = 0.040) even after adjustment for age, prostate specific antigen, pathologic tumor stage and lymph node status. Finally, in PSM patients, RT delivery did not reduce CSM in either univariable or multivariable Cox regression models.ConclusionsIn HR/VHR PCa patients with exclusive GGG 4–5, PSM at RP adversely affect survival. Moreover, RT has no protective effect on CSM. In consequence, lowest possible PSM rates are crucial in such patients.
Pomegranate‐Like KVPO4F@C Microspheres as High‐Volumetric‐Energy‐Density Cathode for Potassium‐Ion Batteries
Authors: Xie Can , Liu Xiaowei , Han Jin , Lv Lei , Zhou Xuan , Han Chunhua , You Ya 
Published: November 2022

AbstractKVPO4F is one of the most competitive cathode candidates for potassium‐ion batteries (KIBs) because of its high output voltage and energy density. Although the gravimetric energy density of KIBs is intensively discussed in literature, little attention is paid to the volumetric energy density. In view of this, pomegranate‐like carbon‐coated KVPO4F microspheres with a high volumetric energy density are designed in this work. The nano‐sized primary particles with carbon sheets in KVPO4F microspheres enable promis rate capability by enhancing the K+ diffusion kinetics, while the micro‐sized spheres guarantee the improvement of cycling stability. Owing to the dense hierarchical microspheres, the volumetric energy density of cells is greatly improved compared to bulk materials. This cathode delivers a reversible capacity of 101.5 mA h g−1 at 0.3 C with an average output voltage of 4.0 V and a capacity retention of 85.1% after 200 cycles. The KVPO4F@C microspheres have a compact density of 2.45 g cm−3 and further offer a high volumetric energy density up to 891.3 Wh L−1. The overcharge behavior of KVPO4F in the first three cycles is also revealed. The presented KVPO4F@C microspheres cathode provides a new sight for developing KIBs with large volumetric energy density.
In Situ Constructing Ultrathin, Robust‐Flexible Polymeric Electrolytes with Rapid Interfacial Ion Transport in Lithium Metal Batteries
Authors: Chen Dongli , Zhu Tao , Zhu Ming , Kang Peibin , Yuan Siqi , Li Yongyang , Lan Jinle , Yang Xiaoping , Sui Gang 
Published: November 2022

AbstractSafety of lithium metal batteries (LMBs) has been improved by using the solid‐state polymer electrolytes, but the performance of LMBs is still troubled by the poor interface of solid electrolytes/electrodes, leading to insufficient interfacial Li+ transport. Here, a novel ultrathin, robust‐flexible polymeric electrolyte is achieved by in situ polymerization of 1,3‐dioxolane in soft nanofibrous skeleton at room temperature without any extra initiator or plasticizer, leading to the electrolyte with rapid interfacial ion transport. This facilitated Li+ transportation is demonstrated by molecular dynamics simulation. Consequently, the as‐prepared electrolyte exhibits excellent cycling performance. The results indicate that the electrolyte works well in the LiFePO4//Li cell at elevated temperature up to 90 °C, and further matches with the high‐voltage LiNi0.8Mn0.1Co0.1O2 cathode. This study provides an effective approach to constructing a practical polymeric electrolyte for fabrication of safe, high performance LMBs.