bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of online‐based cognitive intervention in community‐dwelling older adults with cognitive dysfunction: A systematic review and meta‐analysis
Authors: Chae Hee Jae , Lee Seon Heui 
Published: November 2022

AbstractBackgroundMild cognitive impairment (MCI) or mild dementia imposes a substantial burden on patients, families, and social systems. For MCI or mild dementia patient, cognitive training is required to prevent progression to dementia. With advances in digital health, cognitive interventions using information and communication technology (ICT) have become essential for maintaining independence and functioning in dementia patients.ObjectivesThis study aimed to examine the effectiveness of an ICT‐based cognitive intervention in community‐dwelling older adults with MCI or mild dementia.MethodsA literature search was performed in four databases: Ovid‐Medline, Ovid‐EMBASE, Cochrane Library, and CINAHL. We selected studies published up to April 15, 2021, on topics related to cognitive interventions using ICT in older adults with MCI or mild dementia.ResultsForty‐four studies were included in the analysis. Our meta‐analysis showed that ICT‐based cognitive interventions significantly improved the Mini‐Mental State Examination score in the intervention group compared with that in the control group. Additionally, cognitive training using ICT was significantly effective for a period of more than 30 min, more than 6 weeks, and multi‐domain content. Moreover, a significant reduction in depression was found in the intervention group compared with that in the control group.ConclusionsICT‐based cognitive intervention had a positive effect on cognitive function, depression, and quality of life in older adults with MCI or mild dementia. Application of ICT‐based cognitive training to community‐dwelling older adults with MCI or mild dementia should be expanded, and nurses should play a pivotal role in mediating between these older adults.
The neural correlates of value representation: From single items to bundles
Authors: Zyuzin Jekaterina , Combs Dalton , Melrose James , Kodaverdian Niree , Leather Calvin , Carrillo Juan D. , Monterosso John R. , Brocas Isabelle 
Published: November 2022

AbstractOne of the core questions in Neuro‐economics is to determine where value is represented. To date, most studies have focused on simple options and identified the ventromedial prefrontal cortex (VMPFC) as the common value region. We report the findings of an fMRI study in which we asked participants to make pairwise comparisons involving options of varying complexity: single items (Control condition), bundles made of the same two single items (Scaling condition) and bundles made of two different single items (Bundling condition). We construct a measure of choice consistency to capture how coherent the choices of a participant are with one another. We also record brain activity while participants make these choices. We find that a common core of regions involving the left VMPFC, the left dorsolateral prefrontal cortex (DLPFC), regions associated with complex visual processing and the left cerebellum track value across all conditions. Also, regions in the DLPFC, the ventrolateral prefrontal cortex (VLPFC) and the cerebellum are differentially recruited across conditions. Last, variations in activity in VMPFC and DLPFC value‐tracking regions are associated with variations in choice consistency. This suggests that value based decision‐making recruits a core set of regions as well as specific regions based on task demands. Further, correlations between consistency and the magnitude of signal change with lateral portions of the PFC suggest the possibility that activity in these regions may play a causal role in decision quality.
Assessing the coupling between local neural activity and global connectivity fluctuations: Application to human intracranial electroencephalography during a cognitive task
Authors: Vila‐Vidal Manel , Khawaja Mariam , Carreño Mar , Roldán Pedro , Rumià Jordi , Donaire Antonio , Deco Gustavo , Tauste Campo Adrià 
Published: November 2022

AbstractCognitive‐relevant information is processed by different brain areas that cooperate to eventually produce a response. The relationship between local activity and global brain states during such processes, however, remains for the most part unexplored. To address this question, we designed a simple face‐recognition task performed in patients with drug‐resistant epilepsy and monitored with intracranial electroencephalography (EEG). Based on our observations, we developed a novel analytical framework (named “local–global” framework) to statistically correlate the brain activity in every recorded gray‐matter region with the widespread connectivity fluctuations as proxy to identify concurrent local activations and global brain phenomena that may plausibly reflect a common functional network during cognition. The application of the local–global framework to the data from three subjects showed that similar connectivity fluctuations found across patients were mainly coupled to the local activity of brain areas involved in face information processing. In particular, our findings provide preliminary evidence that the reported global measures might be a novel signature of functional brain activity reorganization when a stimulus is processed in a task context regardless of the specific recorded areas.
Staudinger Ligation and Reactions – From Bioorthogonal Labeling to Next‐Generation Biopharmaceuticals
Authors: Poulou Eleftheria , Hackenberger Christian P. R. 
Published: November 2022

AbstractIn this review, we highlight groundbreaking discoveries and applications of Staudinger reactions in the molecular life sciences, starting from the engineering of the Staudinger ligation as a bioorthogonal reaction until most recent applications in modern bioconjugation methods to generate next‐generation biopharmaceuticals. Bioorthogonal reactions refer to a set of chemoselective transformations in biological environments able to take place in presence of naturally occurring functional groups. The Staudinger ligation set a new paradigm of such transformations, resulting in the development of various labeling and bioconjugation strategies for the modification of (bio‐)molecules of interest.
Accuracy of ultrasound for the detection of placenta accreta spectrum in a universal screening population
Authors: Baumann Hanna Elise , Pawlik Laura Katharina Andrea , Hoesli Irene , Schoetzau Andreas , Schoenberger Heidrun , Butenschoen Annkathrin , Monod Cécile , Manegold‐Brauer Gwendolin 
Published: November 2022

AbstractObjectivesThe current study aimed to determine the sensitivity and specificity of ultrasound for the diagnosis of placenta accreta spectrum (PAS) in a universal screening population and assesses the added value of magnetic resonance imaging (MRI).MethodsThis retrospective analysis evaluated 5219 patients with singleton pregnancies who had a standardized ultrasound (US) examination in our unit and delivered at our institution between 2014 and 2019.ResultsA total of 181 (3.5%) of 5219 (100%) patients had a suspicion or diagnosis of PAS with US. The accuracy of US in detecting placenta increta/percreta showed a sensitivity of 100%, specificity of 99.9%, positive predictive value of 82.4%, and a negative predictive value of 100%. The diagnosis of all forms of PAS showed a sensitivity of 25.8%, specificity of 99.8%, positive predictive value of 80.8%, and a negative predictive value of 97.7%. MRI was concordant with US in 11 of 14 (78.5%) cases of severe forms of PAS and in three of 15 (20.0%) cases with placenta accreta.ConclusionA standardized US evaluation can be applied in a universal screening setting for the diagnosis of severe forms of PAS. MRI is a complementary examination in severe forms of PAS but seems of limited value to discriminate placenta accreta from placenta increta/percreta.
ADAPTIVE CONTROL AND OPTIMAL INPUT DESIGN: A REALISTIC APPROACH
Authors: Fuchs J‐J. J. 
Published: November 2022

SUMMARYThe interplay between estimation and control is crucial in adaptive control algorithms. Most proposed adaptive dual control methods are either too complex for practical applications or else do not rely on any stability proof. By restricting ourselves to a limited class of systems (linear time‐invariant) and a very crude dual action (single‐step optimizing input) we arrive at a very simple approach, which should be interesting for more complex situations also.
ADAPTIVE CONTROL ALGORITHMS FOR WASTE WATER TREATMENT AND pH NEUTRALIZATION
Authors: Goodwin Graham C. , Mcinnis Bayliss , Long Robert S. 
Published: November 2022

SUMMARYThis paper presents adaptive control algorithms which have been designed for use on two applications, namely dissolved oxygen control in activated sludge waste water treatment and control of pH in acidic waste water. Global convergence of the algorithms is established. Simulation studies show that the adaptive control laws can give superior controller performance compared with other conventional control algorithms.
Influences of repeated exposure to low levels of TiO2 nanoparticles on Kruppel‐like factors in 3D Caco‐2 spheroids and mouse intestines
Authors: Cao Wandi , Liu Mingkang , Wang Canyang , Jing Guoxing , Cao Yi 
Published: November 2022

AbstractKruppel‐like factors (KLFs) are a set of transcription factors (TFs) involved in the regulation of many basic biological processes, and recent studies suggested that nanoparticles (NPs) were capable to change KLFs in different models even at non‐cytotoxic concentrations. In this study, we repeatedly exposed 3D Caco‐2 spheroids and mice to TiO2 NPs, one of the most frequently used metal oxide NPs, and investigated the changes of KLF‐signaling pathways based on RNA‐sequencing. Although the internalization of TiO2 NPs did not induce cytotoxicity in vitro, repeated exposure (three times within 7 days) to 15.7 ng/ml TiO2 NPs increased KLF4 but decreased KLF6. Consistently, KLF4/KLF6‐regulated gene ontology terms were altered, including those involved in the regulation of gene expression. We further verified that repeated exposure to 15.7 ng/ml TiO2 NPs increased the expression of KLF4 and proto‐oncogene, bHLH transcription factor (MYC), but decreased the expression of KLF6 and activating transcription factor 3 (ATF3). But with the increase of NP concentrations, the expression of these genes was decreased. In mice following intragastrical exposure to 4.39 and 43.9 mg/kg TiO2 NPs (once a day for 5 continuous days), we observed increased expression of klf4, klf6, myc, and atf3, along with morphological changes of intestines. We concluded that repeated exposure to low levels of TiO2 NPs altered KLF‐signaling pathways in intestinal cells both in vitro and in vivo.
Genetic analysis of a novel SUMF1 variation associated with a late infantile form of multiple sulfatase deficiency
Authors: Zhang Jingjing , Ma Dingyuan , Liu Gang , Zeng Huasha , Wang Yuguo , Luo Chunyu , Hu Ping , Xu Zhengfeng 
Published: November 2022

AbstractBackgroundMultiple sulfatase deficiency (MSD) (MIM#272200) is an ultra‐rare autosomal recessive lysosomal storage disorder caused by mutation of the Sulfatase Modifying Factor 1 (SUMF1) gene.MethodsHerein, we report an eight‐year‐old boy with a late infantile form of multiple sulfatase deficiency. A combination of copy‐number variation sequencing (CNV‐seq) and whole‐exome sequencing (WES) were used to analyze the genetic cause for the MSD patient.ResultsOur results, previously not seen in China, show a novel compound heterozygous mutation with one allele containing a 240.55 kb microdeletion on 3p26.1 encompassing the SETMAR gene and exons 4–9 of the SUMF1 gene, and the other allele containing a novel missense mutation of c.671G>A (p.Arg224Gln) in the SUMF1 gene. Both were inherited from the proband's unaffected parents, one from each. Bioinformatics analyses show the novel variation to be “likely pathogenic.” SWISS‐MODEL analysis shows that the missense mutation may alter the three‐dimensional (3D) structure.ConclusionsIn summary, this study reported a novel compound heterozygous with microdeletion in SUMF1 gene, which has not been reported in China. The complex clinical manifestations of MSD may delay diagnosis; however, molecular genetic analysis of the SUMF1 gene can be performed to help obtain an early diagnosis.
Systematic derivation of partial differential equations for second order boundary value problems
Authors: Kettunen Lauri , Rossi Tuomo 
Published: November 2022

AbstractSoftware systems designed to solve second order boundary value problems are typically restricted to hardwired lists of partial differential equations. In order to come up with more flexible systems, we introduce a systematic approach to find partial differential equations that result in eligible boundary value problems. This enables one to construct and combine one's own partial differential equations instead of choosing those from a pre‐given list. This expands significantly end users possibilities to employ boundary value problems in modeling. To introduce the main ideas we employ differential geometry to examine the mathematical structure involved in second order boundary value problems and exploit electromagnetism as a working example. This provides us with an organized view on the key building blocks behind boundary value problems. Thereafter the approach is naturally generalized to a class of second order boundary value problems that covers field theories from statics to wave problems. As a result, we obtain a systematic framework to construct partial differential equations and to test whether they form eligible boundary value problems.
Stable and radioactive carbon isotopes as indicators of restructuring the pedogenic carbonates in Chernozems during their transition from arable to abandoned state (Cis‐Azov steppe, Russia)
Authors: Khokhlova Olga , Bulysheva Anna , Kuznetsova Alsu 
Published: November 2022

AbstractBackgroundPedogenic carbonates are a key component in the steppe soil system that determined soil‐forming processes, classification position, and also responsible for a carbon cycle.AimInvestigating the processes of carbonate status transformation in Chernozems transiting from arable to self‐restoration state.MethodsThe consequences of land‐use change from arable to self‐restoration abandoned soils for carbonate status have been studied in the chronosequence of Chernozems within the Cis‐Azov steppe, Russia, based on complex examination with the focus on stable and radioactive C isotopes in carbonates.ResultsPedogenic carbonate transformation starts immediately after land‐use change with altering of hydrothermal regime of soils and establishing of a permanent vegetation cover on the surface of abandoned soils when plowing stopped. The main changes are: (1) accumulation of carbonates moves deeper in the profile, (2) decreasing of carbonate C stock, (3) the soft carbonate concretions in the carbonate‐accumulative horizons Bk of aged abandoned soils gain vague diffuse boundaries with the soil mass in contrast to clear boundaries of those concretions in the youngest abandoned and arable soils, (4) the soft concretions with hard core completely disappear from the lowermost part of profile of aged abandoned soils, (5) decrease in the age of carbonates (14C values), (6) and the δ13С values in carbonates increase (become less negative) with time after stop plowing. In approximately 30 years of abandonment, Chernozems transformed to a “new” quasi‐stable state of carbonate profile. The movement of soil solutions in abandoned soils with permanent vegetation occurs under transpiration influence that prevailed over physical evaporation, and that results in a change of the carbon isotopic composition in carbonates. After the soil has been abandoned, carbonates are gradually displaced from the soil horizons of the former arable soils, being simultaneously renewed due to active recrystallization under the influence of plant roots and mesofauna.ConclusionsIn the Chernozems of aged abandoned soils, both radioactive and stable C isotopes in carbonates show renewal as compared with the arable soils, mostly in the nonsegregated carbonates. Thus, the main pathway of the carbonate transformation is through the intrapedal and intercracks soil mass where the nonsegregated carbonates predominate.
Production and characterization of glycolipid biosurfactant from Streptomyces enissocaesilis HRB1 and its evaluation for biomedical and bioremediation applications
Authors: Manikkasundaram Vaishnavi , Baskaran Abirami , Kaari Manigundan , Angamuthu Vignesh , Venugopal Gopikrishnan , Manikkam Radhakrishnan 
Published: November 2022

AbstractThe aim of this investigation is to produce and characterize biosurfactant from Streptomyces sp. HRB1 and to evaluate its biomedical and bioremediation potential. Biosurfactant producing property of Streptomyces sp. HRB1 isolated from petroleum contaminated soil was confirmed by hemolytic and oil spread assays. Based on the results of FT‐IR spectral and GC–MS analysis, the biosurfactant was confirmed as glycolipid type. Biosurfactant from Streptomyces sp. HRB1 exhibited 71% inhibition against Pseudomonas aeruginosa biofilm formation, 77.33% quorum sensing inhibition property against Chromobacterium violeceum MTCC 2656, more than 80% inhibition in antioxidant assays namely, DPPH, ABTS, and metal chelation, promising anti‐proliferative activity against leukemia and myeloma cells with low IC50 values, 96% decolorization of malachite green within 48 h of reaction time, and minimal toxicity against normal cell lines in dose‐dependent manner. The taxonomic position of the potential strain HRB1 was further confirmed as Streptomyces enissocaesilis HRB1 based on their phenotypic and molecular characteristics. To conclude, Streptomyces enissocaesilis HRB1 isolated from petroleum‐contaminated soil is a promising source for low‐cost production of glycolipid biosurfactant with potential biomedical and environmental applications such as antiphytofungal, antibiofilm, anti‐quorum sensing, antioxidant, anticancer, and dye degradation properties.
Segmentation based on environmentally responsible behavior: Evidence from SCUBA divers in Taiwan, the Philippines, and Indonesia
Authors: Lee Tsung Hung , Lin Yi Hsien , Fu Chung‐Jen , Chang Chung‐Feng 
Published: November 2022

AbstractThis study aims to compare the satisfaction and loyalty of SCUBA divers who were segmented into groups based on their level of environmentally responsible behavior (ERB). Overall, 1800 valid questionnaires were obtained from for Taiwan, the Philippines and Indonesia. Multivariate statistical analysis was used for data analysis. Four clusters of SCUBA divers were identified through cluster analysis: blended ERB SCUBA divers, moderate ERB SCUBA divers, lacking ERB SCUBA divers, and practicing ERB SCUBA divers. Each of these clusters exhibited significant differences in tourism satisfaction and loyalty. This study used the ERB variable to effectively categorize SCUBA divers into four groups with several theoretical and practical implications for each, and extended the research on marine tourism development.
Vertical dynamic response of pipe pile embedded in unsaturated soil based on fractional‐order standard linear solid model and Rayleigh‐Love rod model
Authors: Liu Hongbo , Dai Guoliang , Zhou Fengxi , Li Zhongwei , Liang Yuwang 
Published: November 2022

AbstractConsidering the flow‐independent viscosity of soil skeleton and the lateral inertia effect of pipe pile, the vertical dynamic behavior of a pipe pile embedded in unsaturated soil is investigated in this work when the pipe pile is subjected to the vertical dynamic loading. In order to model this problem, the fractional‐order standard linear solid (FSLS) model is introduced to characterize the flow‐independent viscosity of the soil skeleton, the Rayleigh‐Love rod model is employed to specify the lateral inertia effect of pipe pile, while both vertical and radial soil displacement are entirely considered. The analytical solution of the pipe pile complex impedance is obtained through the rigorous theoretical derivation. Numerical results with known analytical solution are finally presented to discuss the influence of the model parameters for the FSLS model, lateral inertia effect and geometrical characteristic for the pipe pile, and saturation degree and intrinsic permeability for the unsaturated soil on the vertical complex impedance of the pipe pile. The main results indicate that enlarging the fractional‐order index, raising the strain relaxation time, or shortening the stress relaxation time will reduce the oscillation amplitude and natural frequency for the dynamic stiffness and damping of the pipe pile but will improve their mean value. The lateral inertia effect of pipe pile has effect on its complex impedance only in the high‐frequency region. The outer and inner radii of pipe pile, pile length, soil saturation degree, and soil intrinsic permeability are highly correlated with the pipe pile complex impedance.
How the current non‐significant effects of person‐centred care on nurses' outcomes could be abated by the WE‐CARE roadmap enablers: A discursive paper
Authors: Van Diepen Cornelia , Fors Andreas , Bertilsson Monica , Axelsson Malin , Ekman Inger , Hensing Gunnel 
Published: November 2022

AbstractAimTo describe the non‐significant results in nurses' outcomes after the implementation of person‐centred care (PCC) and discuss if and how enablers of the WE‐CARE roadmap for implementing PCC could abate the non‐significant results.DesignIn this paper, an innovative framework of enablers in the WE‐CARE Roadmap is explained in relation to increased PCC and nurses' job satisfaction.MethodFindings from a scoping review and published material provided how PCC and nurses' outcomes connect. The WE‐CARE roadmap entails five enablers: Information technology, Quality measures, Infrastructure, Incentive systems and contracting strategies.ResultsThe WE‐CARE roadmap was described and each enabler in the WE‐CARE roadmap is discussed concerning PCC and the nurses' job satisfaction. Thus far, the effects of PCC on nurses' outcomes have been non‐significant. The WE‐CARE roadmap enablers can be implemented to ensure an increased PCC implementation and higher nurses' job satisfaction.
Chillers get quieter, greener, and smaller
Authors: Laufs Konrad 
Published: November 2022

AbstractDiode lasers, even those of low to medium power, need to be cooled – not only to avoid thermal damage, but also to keep their temperature‐dependent output wavelength as constant as possible. Compressor‐based cooling systems are well suited for medium to high‐power lasers, but they are usually large, loud, and generate vibrations. However, there are also compact, quiet, and low‐vibration solutions.
Simple, fast, accurate, and flexible control in laser materials processing
Authors: Jolliffe Cliff 
Published: November 2022

AbstractUntil recently, controlling the motion path of lasers across multiple axes has come with certain limitations in performance, speed, practicalities and, on top, higher complexity and costs. With the development of new modular controllers, flexible solutions that enable a laser to be combined with multiaxis positioning are making it easier for system integrators to design and build advanced systems for a new era of laser applications.
Laser technology for precise material machining applications
Authors: Zhang Nan , Li Lynn , Yu Alexus 
Published: November 2022

AbstractIn recent years, driven by the need for energy conservation and pollution reduction to develop a sustainable society, the building‐integrated photovoltaics (BIPV), centralized photovoltaic power stations and new energy vehicle markets have grown significantly and with that increased the demand for glass that requires more precise micromachining methods.