bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Type of Health Service Utilization in Mumbai Slums including Mobile Health Services: A Community Based Survey
Authors: Patwardhan Maitreyee , Li Shang-Ju , Khushalani Dipika , Dere Harshwardhan , Desai Shripad 
Published: July 2022

Abstract
Objective
Sociodemographic factors influence slum dwellers health seeking behaviors such as choosing a health facility. To better understand the health-seeking behaviors among the slum dwelling residents in Mumbai, India, a cross-sectional community needs assessment was conducted under the support of the Rural India Supporting Trust (RIST).
Results
432 respondents reported using some type of health facility within the past year, including 172 reporting use of private hospitals, 208 reporting use of public hospitals, 23 reporting use of Community Health clinics, and 29 reporting use of some other form of healthcare service. Logistic regression showed that female participants were significantly negatively associated with choosing a general practitioner (log-odds: -0.22, SE: 0.08). Higher education (log-odds: 0.16, SE: 0.08) and higher income (log-odds: 0.28, SE: 0.10) are significantly positively associated with choosing a private hospital. High income was found to be significantly negatively associated with choosing a government hospital (log-odds: -0.23, SE: 0.10). Education was also found to be significantly negatively associated with choosing a community health center (log-odds: -0.40, SE: 0.20). This study showed that health-seeking behaviors for health facilities are consistent with previously published results.
Dissipation Kinetics, Effect of Household Processing, and Dietary Risk Assessment of Chlorantraniliprole Residue in Bitter Gourd and Soil
Authors: MAWTHAM M.M. , Kaithamalai Bhuvaneswari , Angappan Suganthi , Kulanthaisami S 
Published: July 2022

Abstract
A single quadrupole liquid chromatography-mass spectrometry (LC-MS) method was validated to determine chlorantraniliprole residues in bitter gourd fruit, juice, and soil, according to the SANTE guidelines. A linear curve was obtained (R2 > 0.99) with LOD and LOQ at 0.003 mg kg-1 and 0.01 mg kg-1. The accuracy (87–102%) and precision (RSD <5%) of the method was found to be satisfactory. The dissipation pattern of chlorantraniliprole 18.5% SC was studied by spraying twice at ten days intervals, at the recommended dose (X) (25 g a.i. ha-1), and double the recommended dose (2X) (50 g a.i. ha-1). The initial deposit on bitter gourd was 0.72 and 1.41 mg kg-1 and residues persisted up to 15 and 20 days with a half-life of 2.44 and 2.79 days at X and 2X doses, respectively. Simple decontamination techniques were found to reduce residues to the extent of 30 to 80 per cent. The reduction of chlorantraniliprole residues in bitter gourd juice was 40-50 per cent by different washing techniques. The estimated level of RQ indicated (<1) chlorantraniliprole residues pose no dietary risk to consumers at the level detected. Chlorantraniliprole was not found in market and farmgate samples of bitter gourd.
Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation
Authors: Kopycka Katarzyna , Maddison Ben C. , Gough Kevin C. 
Published: July 2022

Abstract
Prion diseases are progressive neurodegenerative disorders with no effective therapeutics. A central event leading to the pathology in the diseases is the conversion of PrPC into PrPSc and its accumulation in the central nervous system. Previous studies demonstrated that PrPC, recombinant PrP (rPrP) and PrP peptides can inhibit the formation of PrPSc. Here, the effectiveness of ovine rPrP mutants at codon 136 and peptides derived from this region were assessed for their ability to inhibit PrPSc replication, using protein misfolding cyclic amplification (PMCA). Based on a rPrP VRQ (rVRQ) genotype background (positions 136, 154 and 171) and mutations at position 136, the most effective inhibitors were V136R, V136K and V136P mutants, with IC50 values of 2–11 nM; activities up to 57 times more potent than rVRQ. rRRQ was also shown to inhibit a range of ruminant prion amplification reactions including with distinct prion strain seeds and substrate PRNP genotypes. The rRRQ was also shown to effectively protect Rov9 cells from scrapie infection when applied at 250 nM. The study demonstrates for the first time that the rPrP sequence can be mutated at sites known to be involved in prion disease susceptibility, to produce inhibitors with improved efficacy.
The Unmet Mental Health Needs of adolescents living With HIV in Eastern Tanzania: Experiences of healthcare providers, adolescents, and caregivers
Authors: Njau Tasiana , Sunguya Bruno , Mwakawanga Dorkasi L. , Minja Agape , Kaaya Sylvia , Fekadu Abebaw 
Published: July 2022

Abstract

Background
Adolescents living with the Human Immunodeficiency Virus (ALWHIV) are at greater risk for depression than their HIV-negative counterparts and may not receive adequate mental health care. In Tanzania, there are no available data on the need for mental health services, particularly interventions for Depression in ALWHIV. Therefore, this study aimed to explore subjective experiences and unmet mental health needs of ALWHIV in Dar es salaam, Tanzania.
Methods
A phenomenological qualitative study design was used. Forty-five in-depth interviews and consultative meetings were conducted with ALWHIV, caregivers, and healthcare providers to explore their experiences and unmet mental health needs for ALWHIV. Data from the consultative meetings with providers were triangulated to validate the obtained information with those from interviews. Data were organized and managed with the aid of NVIvo-11. The thematic analysis framework guided the analysis of data.
Results
High unmet mental health needs were identified because of gaps in access to mental health care and mental health knowledge among health care providers and caregivers of ALWHIV. Depressive symptoms expressed as physical, behavioral, or somatic complaints adversely affect ART adherence, academic performance, substance use, and overall quality of life in ALWHIV. HIV-Care and Treatment Centers (HIV-CTCs) did not conduct formal mental health screenings. Instead, caregivers and Health care providers (HCPs) addressed ALWHIV-related psychological symptoms with threats of death and corporal punishments. No evidence-based depression interventions existed in HIV-CTCs for observed symptoms.
Conclusions
This study reveals a high level of unmet mental health needs and a clear impact on the lives of ALHIV, which may have significant implications for treatment adherence. For improved health outcomes and quality of life for ALWHIV, there is an urgent need to develop effective and scalable interventions to address these mental health needs.
Effectiveness of the air-gap method in pediatric CT examinations
Authors: Masuda Takanori , Funama Yoshinori , Nakaura Takeshi , Sato Tomoyasu , Masuda Shouko , Kiguchi Masao , Oku Takayuki , Gotanda Rumi , Arao Keiko , Imaizumi Hiromasa , Arao Shinichi , Ono Atsushi , Hiratsuka Junichi , Awai Kazuo 
Published: July 2022

Abstract
Background: This study aims to investigate the suitability of the air gap method for radiation dose reduction in pediatric patients during computed tomography (CT) examinations.Methods: We use pediatric anthropomorphic phantoms with a 64 detector-row CT scanner while scanning the chest. A real-time skin dosimeter is placed on the scanner gantry and is positioned at the center of the phantom, on the dorsal surface of the body, and on the left and right mammary glands. In the conventional method, the distance between the CT table and the subject was 0 mm. In the air gap method, the distance between the CT table and subject was 150 mm. We perform a helical scan between the conventional and air-gap methods from the lung apex to the subdiaphragm. The values of the real-time skin dosimeter and image noise are measured and compared for each method.Results: Compared with the conventional method, it was possible to reduce the exposure dose and image noise by approximately 10% and 15%, respectively, using the air gap method (p < 0.05). Conclusion: The airs gap method was useful for reducing the radiation dose by approximately 10% during pediatric CT examinations compared with the conventional method.
Mediating effects of suicidal ideation in the relationship between psychological distress and non-suicidal self-injury among adolescents with major depressive disorder: The roles of sex and urban-rural status
Authors: Li Ruifen , Wang Yanni , Huo Lijuan , Zhu Feng , Zheng Tiansheng , He Kongliang , Lu Shiqi , Hao Jiayue , Li Peng , Su Li , Zhou Yongjie 
Published: July 2022

Abstract
Background
Non-suicidal self-injury(NSSI) is a major public concern, and psychological distress(PD) has been found to be an important risk factor of NSSI. However, little is known about the mediating mechanism underlying this relationship. This study aimed at testing the mediating effects of suicidal ideation(SI) in the relationship between PD and NSSI among adolescents with major depressive disorder. Additionally, it's unclear if this effect exists or differs between sexes or urban-rural status.
Methods
A total of 428 Chinese adolescents with major depressive disorder(MDD) from 9 provinces across China completed self-reported questionnaires regarding PD, SI and NSSI.
Results
The SI mediated the relationship between PD and NSSI, and the estimated ratio of the total effect of PD that could be explained by mediation through SI was 33.59%. The ratio was higher in female adolescents with MDD (39.23%) than in males(18.05%), and it was higher in urban adolescents with MDD(43.35%) than in rural adolescents with MDD(15.55%).
Conclusions
Among adolescents with MDD, PD may influence NSSI behavior through SI. Interventions aimed at reducing NSSI associated with PD may be enhanced by efforts to mitigate SI, especially in females and urban adolescents.
Investigating the response of Al12N12 and B12N12 fullerene-like nanocages toward X-aminopyridine (X = 2 and 3) molecules: DFT study
Authors: Fouegue Aymard Didier Tamafo , Tendongmo Hilaire , Ngankam Eric Sakué , Ntieche Rahman Abdoul 
Published: July 2022

Abstract
The adsorption of 2-aminopyridine (2-AP) and 3-aminopyridine (3-AP) on the external surface of Al12N12 and B12N12 fullerene-like nanocages (FLNs) is probed herein via DFT/M06-2X/6-311G(d,p) level of theory. Results obtained from the topological analysis demonstrated that the APs strongly interact with the boron nitride FLN through B-N covalent interactions with energy values of -345.22 and -328.55 kJ/mol respectively after the adsorption of 2-AP and 3-AP. Moreover, all FLN@X-AP states investigated are spontaneously formed. A significant change in the HOMO-LUMO band gap of B12N12, with values of 22.01 and 32.71 % have been obtained after the adsorption of 2-AP and 3-AP respectively. Accordingly, the conductivity of B12N12 is greatly enhanced by the adsorption of the APs. The above mentioned observations, combined with those found from the analysis of dipole moments and molecular electrostatic potential maps predict B12N12 to be more sensitive to the aminopyridines investigated than the Al12N12 FLN from the theoretical point of view.
Research on Fault Diagnosis of ZPW-2000R Track Circuit Based on OC-SVM and DNN
Authors: xie benkai , cai shuiyong , huang chunlei , yu jianli , chen guangzhi 
Published: July 2022

Abstract
Aiming at the problem that there are many types of faults in the current track circuit and it is difficult to obtain high-quality fault label data, this paper proposes a fault diagnosis method for ZPW-2000R track circuit based on OC-SVM and DNN. In this method, OC-SVM is first used to classify and identify 48 monitoring data collected by ZPW-2000R track circuit to collect signal data of different fault types; then the DNN method is used to train the collected fault data to automatically classify the known fault data. A large number of experiments were carried out on this method using the data of ZPW-2000R track circuit, the diagnostic experimental results show that the proposed fault diagnosis method can effectively automatically collect the novel fault data and accurately detect the fault type, and the accuracy of fault diagnosis can reach more than 98%.
Effect of biodegradable poly-3-hydroxybutyrate amendment on the soil biochemical properties and fertility under varying sand loads
Authors: Brtnicky Martin , Pecina Vaclav , Holatko Jiri , Hammerschmiedt Tereza , Mustafa Adnan , Kintl Antonin , Fojt Jakub Fojt , Baltazar Tividar , Kucerik Jiri 
Published: July 2022

Abstract
Background: Poly-3-hydroxybutyrate (P3HB) is a bacterial intracellular carbon and energy storage polymer, used as a thermoplastic polyester in a wide array of industrial and agricultural purposes. However, it has been relatively unexplored how are the soil microbiome and fertility altered by exogenously applied P3HB. This study aimed to assess the effects of P3HB addition to nutrient restricted soil: its biological properties and lettuce (Lactuca sativa L. var. capitata L.) biomass production. The experiment was designed to the evaluate impacts of spatial arrangement of the relatively organic-rich (soil organic matter, P3HB particles) versus poor fractions of the matrix with confounding factors such as variable microbial biomass, inherent nutrient/energy status, different water relations (due to variable hydrophysical properties of soil augmented by sand at different ratios). Results: The results revealed that P3HB induced inconsistent to contradictory changes in the microbial abundance as well as in most enzymatic activities depending on the sand content. On the other hand, dehydrogenase and urease activities as well as basal and substrate induced soil respirations were mostly enhanced by P3HB addition. Nevertheless, P3HB significantly inhibited lettuce biomass production. Conclusions: We concluded that the P3HB introduction to soil boosts the microbial activity owing to the preferential utilization of P3HB as C source, which depletes soil N and strongly inhibits the plant growth. There was an enhanced microbial activity in P3HB amended soils with high sand content (60–80%), which suggested that in nutrient impoverished soil P3HB can temporarily replace SOM as a C source for microbial communities due to the shift of their structure to preferentially P3HB-degrading microbiome.
Age dependent contribution of entry via the CSF to the overall brain entry of small and large hydrophilic markers
Authors: Qiu Fiona , Huang Yifan , Saunders Norman R , Habgood Mark D , Dziegielewska Katarzyna M 
Published: July 2022

Abstract
Background
Permeability of blood brain barrier to hydrophilic markers has been shown to be higher in the developing brain. Apart from synthesis in situ, any substance detected in the brain parenchyma can originate from two sources: directly through blood vessels of brain vasculature and/or indirectly by entry from the cerebrospinal fluid (CSF) after transfer across the choroid plexuses. The relative quantitative contribution of these two routes to the overall brain entry remains unclear.
Methods
In rats at embryonic day 16, 19 and postnatal day 4 and adults, a small (sucrose, mw. 342 Da) or a large (dextran, mw. 70 kDa) radiolabelled hydrophilic marker was injected intravenously for very short periods of time (30 seconds to 5 minutes) before collection of plasma, cerebrospinal fluid (CSF) & brain samples. Results are presented as concentration ratios between radioactivity in CSF or brain and that in plasma (%).
Results
The dextran brain/plasma ratio five minutes post injection was similar (2–4%) from E16 to adulthood whereas the sucrose brain/plasma ratio was higher in fetal brains but was comparable to dextran values in the adult. Sucrose CSF/plasma ratio was higher than that of the brain in fetal animals and also decreased with age. In very short experiments involving fetal animals, entry of sucrose in the CSF after only 30 seconds was similar to that of dextran and both markers showed similar brain/plasma ratios.
Conclusions
In the developing brain the apparent higher brain entry of a small hydrophilic marker such as sucrose can be attributed to its higher entry into the CSF and subsequent diffusion into the brain. By contrast, movement of a larger marker like 70 kDa dextran between the brain and CSF would be restricted by specialised junctional complexes between the neuroepithelium lining the ventricles. Brain/plasma ratios of 70 kDa dextran were similar in fetal and adult rats. Therefore 70 kDa dextran should be considered an appropriate marker if brain residual vascular space is to be measured, especially in younger animals.
Experimental and Numerical Investigation of Using Waste Glass Aggregates in Asphalt Pavement to Mitigate Urban Heat Islands
Authors: Mammeri Abdelhamid , Vaillancourt Michel , Shamsaei Mohsen 
Published: July 2022

Abstract
In this study, the experimental and numerical effects of using waste glass as aggregates of asphalt pavement are evaluated. The main reason for using this waste material as aggregates of hot mix asphalt (HMA) was to alleviate an environmental problem associated with asphalt pavements called urban heat islands (UHI). This phenomenon can increase the temperature in urban areas compared to their suburbs. Regarding the experimental part, two different HMA mixtures containing 100% limestone aggregates (HMAL) and 100% glass aggregates (HMAG) were made. An experimental setup was used to simulate the solar radiations on top of HMA specimens. As a result, thermal parameters, including thermal conductivity, thermal diffusivity, and specific heat capacity, were measured and calculated using the heat transfer equations and the heat transfer test. These results were then used to develop finite element models for two different pavement structures with different asphalt concrete layers (one of them with HMAL and the other with HMAG). Furthermore, the air temperature data, extracted by TRNSYS software for Bechar city in Algeria, was used for modeling. The surface temperature, first, second, and third interface temperatures in the asphalt pavement were obtained. The results revealed that using this waste aggregate increased the surface temperature during the day, which can make it susceptible to rutting. However, it reduced the surface temperature at night. More importantly, the HMAL absorbed 34 % and released 47% more heat than HMAG during days and nights. Hence, the HMAG performance can mitigate the UHI effects. Moreover, using this waste material as aggregates in HMA can introduce a recycling method with low costs.
Spectroscopic characterization and in vitro studies of biological activity of bradykinin derivatives
Authors: Proniewicz Edyta , Burnat Grzegorz , Domin Helena , Iłowska Emilia , Roman Adam , Prahl Adam 
Published: July 2022

Abstract
Eleven multiple analogs of bradykinin (BK) – a peptide that is a natural ligand of B1 and B2 receptors – were synthesized. Their biological activity was evaluated on T-REx cell lines expressing B1 or B2 receptors using the intracellular IP1 assay. The mRNA expression of B1R and B2R in the lysate of tumor cell lines, e.g., U87-MG (human astrocytoma), SHP-77 (human small cell lung cancer), and H4 (human brain glioma), was determined. For five B1R antagonists, adsorption at the liquid/solid interface (Au nanoparticles (AuNPs) served as the solid surface) was discussed in terms of the vibrations of the molecular fragments (structural factors) responsible for the biological properties of these analogs.
Semi-active control of a new quasi-zero stiffness air suspension for commercial vehicles based on event-triggered H∞ dynamic output feedback
Authors: Jiang Xinwei , Xu Xing , Chen Lei , Wang Feng , Atindana Vincent Akolbire 
Published: July 2022

Abstract
To further improve the multi-objective comprehensive vibration isolation performance of commercial vehicles and save network resource occupation, this paper proposes a new configuration of semi-active quasizero stiffness air suspension (QZSAS) with network communication architecture, and a matching dynamic output feedback control (DOFC) strategy considering eventtriggered mechanism. The semi-active QZSAS is mainly composed of a positive stiffness air spring, a pair of negative stiffness double-acting cylinders and two CDC dampers. Event-triggered mechanism determines whether the control signal is updated by judging the measured signal to save communication resources. Firstly, The nonlinear stiffness of the suspension system is regarded as an uncertain parameter and processed by constructing a Takagi-Sugeno (T-S) fuzzy controller model. Then, the Lyapunov-Krasovskii functional method is employed to design the dynamic output feedback controller under the linear matrix inequality (LMI) constraint to ensure system stability with H ∞ performance index. Finally, the co-simulation and hardware-in-the-loop (HiL) test results show that the presented new semi-active QZSAS structure and the DOFC method considering eventtriggered mechanism can significantly improve the multiobjective performance of commercial vehicles under different driving conditions with significantly reducing the network communication burden.
Taurocholate uptake by Caco-2 cells is inhibited by pro-inflammatory cytokines and butyrate
Authors: Couto Mafalda , Andrade Nelson , Magro Fernando , Martel Fátima 
Published: July 2022

Abstract

Inflammatory bowel disease (IBD) is a group of chronic and life-threating inflammatory diseases of the gastrointestinal tract. The active intestinal absorption of bile salts is reduced in IBD, resulting in higher luminal concentrations of these agents that contribute to the pathophysiology of IBD-associated diarrhea. Butyrate is a short-chain fatty acid produced by colonic bacterial fermentation of dietary fibers. Butyrate utilization is impaired in the intestinal inflamed mucosa of IBD patients. The aim of this work is to investigate the link between IBD and bile acid absorption, by testing the effect of the pro-inflammatory cytokines TNF-a and IFN-γ and butyrate upon 3H-taurocholate uptake by Caco-2 cells. The results obtained show that the proinflammatory cytokines TNF-a and IFN-γ inhibit Na+-independent, non-ASCT-mediated 3H-TC uptake by Caco-2 cells. The inhibitory effect of these cytokines on 3H-taurocholate uptake is PI3K- and JAK2-mediated. Moreover, butyrate in high but physiological concentrations was also found to inhibit 3H-TC uptake and showed an additive effect with IFN-γ in reducing 3H-taurocholate uptake. So, an interaction between fiber-derived butyrate and inflammatory cytokines appears to exist in relation to bile salt intestinal uptake in IBD, which may participate in the link between fiber intake and IBD.