bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Public and Private Hospital-Based Health Information Technology: A Cross-Sectional Study in Hospitals in the Municipality of Lubango-Angola
Authors: Sanjuluca Tomas Hambili , Almeida Anabela , Correia Ricardo 
Published: March 2022

Abstract
The availability of information has a significant impact on the management of health organizations, mainly when it is used for decision-making. For information to be available in a timely and reliable manner, these organizations must have a proper information system effectively used. The objective of this study was to be exploring the level of use of information technology (IT) supporting information systems management in public and private health sector located in the municipality of Lubango, Angola. That is a descriptive cross -sectional study based on a questionnaire applied to ten hospital administrators of private-public health organizations situated in Lubango. The questionnaire focuses on the profile and organization of each health institution and IT usage. The results show that 70% of all the health institutions studied do not have a department responsible for information technology. Most hospital departments do not have specific clinical software. In 80% of health organizations studied, the accounting and finance area has software and Internet access. The study has identified the lack of Health Information Technology in hospitals province of Huila is low or even non-existent. Furthermore, the most significant focus of information management based on information technology is concentrated on administrative and financial information management and not uses in clinical information systems (electronic patient records). This supports other studies that indicate that health care managers are adopting low-cost IT electronic health information systems. This study is the first conducted in this health region of Angola that assesses the reality of public and private health organizations in using information technologies to support the management of hospital information systems. With the patient, the hospital's mission, the results of this study can awaken managers to the need to use IT to manage clinical information.
Anisotropic index strength behavior and failure mode validation of weathered shale
Authors: Abbas Hasan Ali 
Published: March 2022

Abstract
The failure mode limitations presented in the International Society for Rock Mechanics (ISRM) were recognised as an obvious issue by invalidating most of the failure modes along the bedding plane. In this study, the anisotropic behaviour of index strength and failure mode of weathered shale are evaluated by utilising the point load test (PLT) and the block punch index (BPI). The outcomes elaborate that the degree of anisotropy of PLT is four times the BPI degree of anisotropy. The failure mode of weathered shale is observed to be controlled by the bedding plane orientation (β). Particularly, when the point loading is not perpendicular to the bedding plane orientation, it is necessary to consider the inclined failure mode along bedding since eliminating these results may cause a significant over-prediction of index strength. Meanwhile, the presence of secondary failures along a bedding in weathered shale under BPI is because of the normal stress distribution. Consequently, the very low bonding between the bedding planes is not able to resist the tensile stresses developed at the specimen faces during punching. The study also highlighted the effect of the horizontal angle of bedding orientation (θ) with respect to the puncher.
Isolation of angiolipoma tissue sections with Color-Based Segmentation Using K-Means Clustering
Authors: Radak Mahyar 
Published: March 2022

Abstract
In this paper, we used Color-Based Segmentation Using K-Means Clustering using an intelligent tissue filtering algorithm to identify tissue-based image regions containing thick-walled capillaries with fibrin clots, between mature lipocytes and fibrin septum, and HE angiolipoma spots. Our algorithm for segmentation on the image of tissue impregnated with hemotoxylin and eosin (H&E). This staining method helps pathologists identify different types of tissue. This algorithm was able to identify and extract angiolipoma tissue nuclei and isolate nuclei and tissues attached to angiolipoma nuclei from the whole image.
RIS-Assisted Multi-User MIMO-DQSM Transmission System
Authors: Castillo-Soria Francisco R. , Kumaravelu Vinoth Babu , Azurdia-Meza Cesar A. , Sim´on Jorge , Gutierrez Carlos 
Published: March 2022

Abstract
This paper presents a reconfigurable intelligent surface (RIS) assisted multi-user (MU) multiple-input multiple-output (MIMO) system. Instead of being applied at the remote RIS, the phase shift vector is applied at the base station (BS) by using an additional precoding stage. The overall system performance is improved by incorporating a double quadrature spatial modulation (DQSM) transmission technique. Results show that the proposed system has gains of up to 17 dB in bit error rate (BER) and a reduction in detection complexity of 51% when compared with the conventional MU-MIMO system based on spatial multiplexing (SMux). Compared with a similar system based on amplify and forward (AF) relay-assisted technique, the proposed system has up to 18 dB gain in BER performance under the same conditions and parameters. Mainly, the proposed system significantly reduces the signal processing required at the RIS.
PPT1 Deficiency-Induced GABAAR Hyperpalmitoylation Impairs Synaptic Transmission and Memory Formation
Authors: Tong Jia , Gao Jingjing , Feng Bingyan , Zhao Xing , Li Junmei , Qi Yawei , Zhang Qiuyu , Lu Chengbiao , Peng Shiyong 
Published: March 2022

Abstract
Palmitoylation is a reversible and dynamic process involving addition of palmitic acid to cysteine residues of proteins. Studies have indicated that a variety of neuronal receptors, including glutamate receptors such as AMPAR, NMDAR, and GABAAR, are palmitoylated, which contributes to the dynamic modulation of synaptic strength in response to neuronal activity. However, little is known about the depalmitoylation of these receptors. In this study, we adopted PPT1-deficient mice, an animal model that closely mimics human disease of infantile neuronal ceroid lipofuscinosis (INCLs), by knocking in a CLN1 c.451C > T nonsense mutation. We identified for the first time that the GABAARα1 subunit rather than AMPAR is the substrate of PPT1. In PPT1-deficient mice, we found the excessive palmitoylation and extended membrane location of GABAAR. Miniature inhibitory postsynaptic current (mIPSC) recorded from CA1 pyramidal neurons of PPT1-KI mice was also enhanced without disturbance of excitatory neuronal transmission. Spatial learning and memory deficits with enhancement of γ oscillation while attenuation of phase coupling was shown in the mice at as early as 2-month-old. Application of N-tert-butylhydroxylamine hydrochloride, a thioesterase mimetic, attenuated PPT1 mutation-induced GABAAR hyperpalmitoylation and its membrane accumulation with improved neuronal transmission and memory functions in the mice. These data provide new insights into the mechanisms of neuronal disorder caused by depalmitoylation deficiency and offer a clue for further intervention for INCLs and other neurodegenerative diseases.
Elevated Expression of The RNA-Binding Protein IGF2BP1 Enhances The Mrna Stability and Translation Efficiency of INHBA to Promote The Invasion and Migration of Esophageal Squamous Cancer Cells
Authors: Wang Juan-Juan , Chen Ding-Xiong , Zhang Yu , Xu Xin , Cai Yan , Hao Jia-Jie , Wang Ming-Rong 
Published: March 2022

Abstract
Background: The mechanisms underlying the occurrence and development of esophageal squamous cell carcinoma (ESCC) remains to be elucidated. The present study aims to investigate the roles and implications of IGF2BP1 overexpression in ESCC.Methods: IGF2BP1 protein expression in ESCC samples was assessed by immunohistochemistry (IHC), and the mRNA abundance of IGF2BP1 and INHBA was analyzed with TCGA datasets and by RNA in situ hybridization (RISH). Cell viability, migration, invasion and in vivo metastasis assays were performed to explore the roles of IGF2BP1 overexpression in ESCC. RNA immunoprecipitation sequencing (RIP-seq) and mass spectrometry were applied to identify the target RNAs and interacting proteins of IGF2BP1, respectively. RIP-PCR, RNA pulldown, immunofluorescence (IF), gene-specific m6A PCR and RNA stability assays were used to uncover the molecular mechanisms underlying the malignant phenotypes of ESCC cells caused by IGF2BP1 dysregulation. The methylation level of the IGF2BP1 promoter region was detected by methylation-specific PCR (MSP-PCR). Results: IGF2BP1 overexpression was detected in ESCC tissues and associated with the depth of tumor invasion. Knockdown of IGF2BP1 inhibited ESCC cell invasion and migration as well as tumor metastasis. Mechanistically, we observed that IGF2BP1 bound and stabilized INHBA mRNA and then enhanced the translation of INHBA, leading to the activation of Smad2/3 signaling, thus promoting malignant phenotypes. The mRNA level of INHBA was upregulated in ESCC tissues as well. Furthermore, IGF2BP1 interacted with G3BP stress granule assembly factor 1 (G3BP1) and activated the INHBA-Smad signaling. In addition, IGF2BP1 mRNA expression in ESCC cells was negatively correlated with the level of its promoter methylation.Conclusions: Elevated expression of IGF2BP1 is a frequent event in ESCC tissues and might be a candidate biomarker for the disease. IGF2BP1 overexpression promotes the invasion and migration of ESCC cells by activating the INHBA-TGF-β-Smad2/3 pathway, providing a potential therapeutic target for ESCC patients with high expression of IGF2BP1.
Analysis on the Impact of Taiwan Far-field Earthquakes on the Disaster Avoidance Behavior of People in High-rise Buildings in Large Cities in Southeast China
Authors: dongping li , Qingquan Tan , Jinfei Yin , yibo jian 
Published: March 2022

Abstract
Taiwan Province is an earthquake-prone area, and strong earthquakes in Taiwan could affect coastal cities in the mainland. The high-rise buildings in coastal cities often are seriously affected, which can cause social panic. Therefore, it is necessary to study the seismic impact of moderate and strong earthquakes in Taiwan on the mainland coast to accurately analyze the effect on buildings in this area, especially the responses of people in high-rise buildings after the earthquake, and to provide a relatively accurate reference for the evaluation of the timely restoration of social order. This paper uses the 43.29 million mobile phone location records collected after the M6.1 earthquake in Hualien, Taiwan on April 18, 2021, for the bandwidth selection in kernel density estimation in different regions and conducts a quantitative density analysis of 331 buildings using the communication check-in data after the earthquake on different temporal and spatial scales. Through this work, an exponential model of people’s responses in high-rise buildings to far-field strong earthquakes in Taiwan is obtained, and the flow pattern of people in regard to disaster avoidance in high-rise buildings after far-field nondestructive earthquakes is summarized. This paper can be a reference for the local government to judge the impact of Taiwan's far-field earthquakes and to make decisions with respect to disaster relief.
PREVALENCE OF RISK FACTORS AND COMORBID CONDITIONS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS
Authors: Jain Abhishek , Singh Lalit , Agrawal Anurag , Tandon Rajeev , Agrawal Nipun 
Published: March 2022

Introduction: COPD is associated with several risk factors and co morbid conditions. Dealing
with co-morbidity needs a patient centered approach, rather than a disease oriented approach7.
The present study was conducted to study risk factors and co morbid conditions of COPD
patients.
Material and Methods: The present study was conducted in department of Pulmonary
Medicine at Shri Ram Murti Smarak Institute of Medical Sciences with respiratory complaints
over a period of one and a half year. The data was collected in terms of demographic features,
anthropometric measurements and various risk factors and co morbid conditions. Spirometry
was performed thrice and the largest values of both FVC and FEV1 were noted from three
technically satisfactory curves. COPD severity was classified based on Spirometric
assessment according to the GOLD classification. Categorical variables were analyzed using
proportions and percentages.
Results: In a study of 201 cases that were diagnosed as a case of COPD the mean age was 62.6
years and male predominance. Majority of the patients had sedentary life style and were from
poor class. The co morbid conditions anemia, cardiac, hypertension, diabetes mellitus, lipid
disorders, thyroid disorders, osteoporosis, psychiatric illness, ophthalmic defects and
obstructive sleep apnea was found in 43.8%, 52.2%, 65.2%, 52.2%, 51.7%, 64.7%, 72.1%,
66.7%, 28.9% and 54.2% respectively.
Conclusion: Co morbidities should be taken into consideration while prescribing multiple
drugs so that side effects and interactions of drug can be monitored and quality of life can be
improved.
Exploring the Equity Impact of Current Digital Health Design Practices: Protocol for a Scoping Review
Authors: Evans Laura , Evans Jay , Pagliari Claudia , Källander Karin 
Published: March 2022

Background
The field of digital health has grown rapidly in part due to digital health tools’ potential to reduce health inequities. However, such potential has not always been realized. The design approaches used in digital health are one of the known aspects that have an impact on health equity.

Objective
The aim of our scoping review will be to understand how design approaches in digital health have an impact on health equity.

Methods
A scoping review of studies that describe how design practices for digital health have an impact on health equity will be carried out. The scoping review will follow the methodologies laid out by Arksey and O’Malley, the Joanna Briggs Institute, and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist. The PubMed, Embase, Web of Science, and ACM Digital Library databases will be searched for peer-reviewed papers. The ProQuest Dissertations and Theses and Global Index Medicus databases will be searched for gray literature. The results will be screened against our inclusion and exclusion criteria. Subsequently, the data extracted from the included studies will be analyzed.

Results
As of March 2022, a preliminary search of the peer-reviewed databases has yielded over 4900 studies, and more are anticipated when gray literature databases are searched. We expect that after duplicates are removed and screening is completed, a much smaller number of studies will meet all of our inclusion criteria.

Conclusions
Although there has been much discussion about the importance of design for lowering barriers to digital health participation, the evidence base demonstrating its impacts on health equity is less obvious. We hope that our findings will contribute to a better understanding of the impact that design in digital health has on health equity and that these findings will translate into action that leads to stronger, more equitable health care systems.
Workshop Upgrading Kemampuan Mengajar Guru Bahasa Asing SMA/SMK/MA Se-Kabupaten Sampang: Sebuah Penelitian dan Pengembangan Pendidikan
Authors: Sari Yohana Ika Harnita , Soelistiyowati Endang , Nuraniwati Tri , Tyas Agnes Siwi Purwaning , Vardhani Nabilla Kusuma , Setyaningsih Wahyu Handayani , Dwiwardani Wury , Hasanah Ummul , Pambudi Arismoyo Damar 
Published: March 2022

Penguasaan bahasa asing merupakan salah satu kunci dalam memenangkan persaingan di era globalisasi ini. Oleh karenanya, pembelajaran bahasa asing khususnya di tingkat pendidikan menengah/kejuruan perlu diupayakan agar memiliki kondisi yang ideal agar outcome pembelajaran dapat tercapai sehingga lulusannya lebih berdaya saing. Dalam kenyataannya, di banyak daerah di Indonesia belum memiliki kondisi yang ideal untuk pembelajaran bahasa, tidak terkecuali di Kabupaten Sampang, Jawa Timur yang indeks pendidikannya masih rendah. Kompetensi pedagogis, mindset, dan motivasi pengajar menjadi hal yang krusial dalam penentuan keberhasilan pembelajaran bahasa di daerah tersebut. Oleh karenanya, pelatihan untuk peningkatan kemampuan mengajar guru bahasa asing menjadi jalan keluar yang tepat untuk meminimalisir dampak negatif dari kurangnya penguasaan kompetensi guru secara pedagogis. Penelitian ini bertujuan untuk mendeskripsikan tahapan R&D dari kegiatan Pengabdian kepada Masyarakat yang berjudul “Workshop Upgrading Kemampuan Mengajar Guru Bahasa Asing (Bahasa Inggris dan Lainnya) SMA/SMK/MA Se-Kabupaten Sampang” yang diselenggarakan pada tanggal 17-19 September 2019. Secara umum, tahapan R&D yang dilaksanakan selama bulan Mei-Oktober 2019 tersebut diadaptasi dari siklus R&D yang dikembangkan oleh Borg & Gall (2003), yaitu (1) pengumpulan informasi dan penelitian, (2) perencanaan, (3) mengembangkan produk, (4) diseminasi 1 dan implementasi , (5) evaluasi, dan (6) diseminasi 2.
The Impact of Using Instagram and Whatsapp Social Media on the Intensity of Learning Arabic Language/ تأثير استخدام وسائل التواصل الإجتماعي إنستغرام و واتساب على حافز تعلم اللغة العربية
Authors: Amirullah Nur Ikhsan 
Published: March 2022

The objectives of the study in this topic is to find out the motivation of students’ learning of the Arabic language in the experimental study and the control study and to find out the effect of using social media Instagram as a learning media on motivating students in the eighth-graders in Islamic Junior High School 6 Sragen to learn Arabic. This study is an experimental study method quantitative method. The method of data collection used is questionnaires. The media used is Instagram. The method of analysis used is paired sample T-test and independent sample T-test. The use of the Instagram learning media has a positive effect on stimulating learning, and this is required by the presence of the change in the paired sample T-test, and the significance score was less than 0,05 (P = 0,001 < 0,05). Then there are significant differences in the scores of the experimental class and the control class students. It can be demonstrated by the independent T-test result (post-test) that the calculated T value (2,539 > 1,999) and the significance score is less than 0,05 (P = 0,000 < 0,05).
Dampak Model Pembelajaran Inkuiri Terbimbing terhadap Hasil Belajar IPA Ditinjau dari Gender/Jenis Kelamin
Authors: Kurniawati Ni Made Dewi , Suardana Nyoman , Sudiatmika A. A. Istri Agung Rai 
Published: March 2022

Pembelajaran IPA masih bersifat konseptual, teoretis, dan hapalan melalui buku, masih adanya kecenderungan pembelajaran berpusat pada guru, dan siswa tidak dibiasakan menyusun simpulan pembelajaran serta mengomunikasikan hasilnya dengan benar. Hal ini bermuara pada rendahnya hasil belajar IPA siswa. Penelitian ini bertujuan menganalisis model pembelajaran dan gender terhadap hasil belajar. Penelitian ini menggunakan jenis penelitian Quasi Experimental (Eksperimen Semu) menggunakan desain pretest posttest nonequivalent control group dengan pendekatan kuantitatif. Populasi dalam penelitian ini adalah siswa kelas VIII SMP dengan jumlah siswa 400 siswa. Penentuan sampel pada penelitian ini menggunakan teknik simple random sampling, yaitu menggunakan empat kelas sebagai sampel, dengan menetapkan dua kelas sebagai kelompok eksperimen dan dua kelas sebagai kelompok kontrol dengan jumlah 80 orang siswa. Data dalam penelitian ini dikumpulkan dengan tes. Data dianalisis dengan menggunakan desain analisis faktorial 2×2 dengan uji Anacova Dua Jalur. Hasil penelitian menunjukkan bahwa terdapat perbedaan hasil belajar siswa pada kelompok model pembelajaran dengan nilai statistic F = 130,35 dan nilai signifikan sebesar 0,00. Terdapat interaksi gender terhadap hasil belajar IPA dengan nilai statistic F= 11,714 nilai signifikan sebesar 0,001, dan terdapat pengaruh interaktif antara model pembelajaran dan gender terhadap hasil belajar IPA dengan nilai statistic F = 4,883 dan nilai signifikan sebesar 0,029. Maka, model pembelajaran inkuiri terbimbing lebih efektif untuk meningkatkan hasil belajar IPA siswa.
PURI AGUNG NEGARA JEMBRANA (SEJARAH, STRUKTUR DAN FUNGSI SERTA POTENSINYA SEBAGAI SUMBER BELAJAR SEJARAH DI SMA)
Authors: Arimbawa I Putu Eka , Purnawati Desak Made Oka , Maryati Tuty 
Published: March 2022

Penelitian ini bertujuan untuk mengetahui: (1) sejarah berdirinya Puri Agung Negara Jembrana di Kelurahan Banjar Tengah, Kecamatan Negara, Kabupaten Jembrana, (2) struktur dan fungsi Puri Agung Negara Jembrana tersebut, dan (3)potensi yang terdapat di Puri Agung Negara Jembrana yang dapat dijadikan sumber belajar sejarah di SMA. Metode penelitian yang digunakan yaitu pendekatan kualitatif deskriptif meliputi: (1) penentuan lokasi penelitian; (2) teknik penentuan informan; (3) teknik pengumpulan data menggunakan observasi, wawancara dan studi dokumen; (4) teknik validasi data menggunakan triangulasi metode dan triangulasi sumber; (5) teknik analisis data memakai model interaktif. Hasil penelitian menujukkan bahwa: sejarah Puri Agung Negara Jembrana memiliki kaitan erat lintasan sejarah Kerajaan Jembrana. Hal ini dikarenakan Puri Agung Negara Jembrana merupakan pusat kekuasaan dan pemerintahan Kerajaan Jembrana ketika dipindahkan dari Puri Gede Jembrana hingga Kerajaan jembrana berubah menjadi Kabupaten Jembrana pada tahun 1960. Struktur Puri Agung Negara Jembrana menggunakan konsep Tri Mandala yaitu Nista Mandala, Madya Mandala, dan Utama Mandala dengan fungsi tiap bangunan sesuai kaidah Sanga Mandala. Fungsi Pura Dalem Jawa yaitu (1) fungsi religius, (2) fungsi sosial-politik, dan (3) fungsi budaya. Adapun potensi Puri Agung Negara Jembrana berdasarkan analisis kurikulum dan silabus ialah aspek historis dan aspek peninggalan yang kemudian disusun dalam Rencana Program Pembelajaran untuk dapat dimanfaatkan sebagai sumber belajar sejarah di SMA.
Drones de coronavírus como um gênero cinematográfico
Authors: Kaplan Caren , Zimmermann Patricia R. , Fuser Marina Costin 
Published: March 2022

Durante março e início de abril de 2020, na medida em que a Covid-19 circulava pelo mundo, imagens de cidades surpreendentemente vazias passaram a pipocar nas redes sociais e postadas no YouTube. As imagens, produzidas em geral por operadores de drones profissionais ou amadores, foram apresentadas de maneira tão semelhante que sugere que um gênero cinematográfico específico possa estar surgindo.
Quando o curador do Hallwalls, Edmund Cardoni, postou imagens de drones de Buffalo, em Nova York, que na época se tornava o segundo ponto de acesso do coronavírus no estado de Nova York, uma conversa que começou no Facebook gerou esta entrevista, publicada no Quorum da Film Quarterly. Patricia R. Zimmermann, que integra o conselho editorial da Film Quarterly, publicou novamente o vídeo e perguntou “a filmagem do drone do coronavírus é um novo gênero cinematográfico?” Caren Kaplan, que pesquisa imagens aéreas e militarismo, respondeu “Que interessante! O símbolo icônico da tecnologia à distância produz imagens de distanciamento social.” Uma discussão animada se seguiu, levando B. Ruby Rich a convidá-las a desenvolver o diálogo no Quorum da Film Quarterly.