bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supramalleolar Lateral Opening-Wedge Osteotomy in Conjunction With Progressive Collapsing Foot Deformity Reconstruction for PCFD With Ankle Instability
Authors: Haraguchi Naoki , Asano Kota , Arimoto Tatsuya , Niki Hisateru , Ota Koki , Ozeki Takuma , Gibu Masaki , Kanetake Yoshihiko , Tsutaya Atsushi 
Published: June 2022

Background: Reconstruction of progressive collapsing foot deformity (PCFD) with ankle instability (PCFD class E) remains a substantial challenge to orthopaedic surgeons. We report the outcomes of PCFD class E treated by means of a relatively standard PCFD foot reconstruction approach with the addition of a supramalleolar lateral opening-wedge osteotomy. Methods: We conducted a retrospective study of 13 patients (15 ankles) who underwent this procedure for PCFD class E between 2010 and 2021. Mean follow-up time was 3.8 (range, 2-6.3) years. Clinical assessment was based on the Japanese Society for Surgery of the Foot (JSSF) ankle/hindfoot scale as well as a Self-Administered Foot Evaluation Questionnaire (SAFE-Q). Radiographic assessments, including identification of the mechanical ankle joint axis point and a modified valgus Takakura-Tanaka osteoarthritis grade, were recorded. Results: The mean JSSF score improved significantly from 45.2 preoperatively to 83.9 postoperatively ( P < .001). SAFE-Q scores at the final follow-up were 70.1 for the pain and pain-related subscale, 75.4 for the physical functioning and daily living subscale, 83.0 for the social functioning subscale, 74.4 for the shoe-related subscale, and 78.1 for the general health and well-being subscale. Radiographic measurements showed improvement in the tibiotalar tilt angle (average improvement: 5.4 degrees); orientation of the talus joint line relative to the ground (average improvement: 14.0 degrees); anteroposterior talus–first metatarsal angle (average improvement: 11.2 degrees), talonavicular coverage angle (average improvement: 21.6 degrees), and lateral talus–first metatarsal angle (average improvement: 17.0 degrees). Postoperatively, the mechanical ankle joint axis point moved medially for all patients and into the medial half of the ankle joint for 7 patients. The modified osteoarthritis stage improved postoperatively in most cases. Conclusion: In this select and relatively small group of patients who had a supramalleolar lateral opening-wedge osteotomy combined with PCFD reconstruction, we measured general improvement in JSSF scores and radiographic variables. Long-term durability of the procedure remains unknown. This procedure may be an option for preserving the ankle joint in treatment of PCFD class E with osteoarthritis of the ankle. Level of Evidence: Level IV, therapeutic.
Cyclin-dependent kinase 4/6 inhibitor treatment use in women treated for advanced breast cancer: Integrating ASCO/NCODA patient-centered standards in a community pharmacy
Authors: Marineau Alexandre , St-Pierre Catherine , Lessard-Hurtubise Roxanne , David Marie-Ève , Adam Jean-Philippe , Chabot Isabelle 
Published: June 2022

Background Outpatients treated with oral anti-cancer drugs, including selective cyclin-dependent kinase 4/6 inhibitors (CDK4/6i), may benefit from a pharmacy practice setting adapted to support proper oral anti-cancer drug monitoring. This real-world study aimed to characterize patient-centered pharmacy practice aligned with American Society of Clinical Oncology (ASCO)/National Community Oncology Dispensing Association (NCODA) standards and to describe its impact on CDK4/6i treatment use. Methods This retrospective study included women with confirmed hormone receptor-positive/human epidermal growth factor 2 negative locally advanced or metastatic breast cancer treated with either palbociclib, abemaciclib or ribociclib combined with letrozole or fulvestrant. Pharmacists collected patient characteristics, clinical activities, and treatment patterns using data from the pharmacy chart. CDK4/6i treatment adherence rates were estimated based on medication claims data. Time-to-treatment discontinuation, a proxy for time-to-event, was assessed using the Kaplan-Meier estimate. Results Of the 195 patients assessed for eligibility, 65 were included in this study. The median observation duration was 13.6 months. An average of seven pharmaceutical care activities (range 2.8–21.7) per patient was documented for each treatment cycle. The mean proportion of days covered was 89.6%. The median time-to-treatment discontinuation was estimated at 44.2 months in patients treated with CDK4/6i + letrozole and 17.0 months in patients treated with CDK4/6i + fulvestrant. The average relative dose intensity was 85%, and the benefits of treatment were maintained regardless of the relative dose intensity levels. Conclusion A structured patient-centered pharmacy practice model integrating the ASCO/NCODA patient-centered standards and ongoing communication with patients and healthcare providers ensure timely refills, close monitoring, and allows patients to achieve high adherence and persistence rates comparable to those reported in clinical trials.
Detection of cerebral aneurysm and intracranial vertebral dissection using non-enhanced magnetic resonance imaging in emergency setting: Emphasis on magnitude image of susceptibility-weighted image
Authors: Bae Dae Woong , Lee Jong Heon , Shin Jae Ho , Ihn Yon Kwon , Sung Jae Hoon 
Published: June 2022

Purpose To evaluate image features and diagnostic performance of susceptibility-weighted image (SWI) in detection of intracranial vertebral artery dissection (VAD) and unruptured intracranial aneurysm (UIA). Materials and methods From January 2015 to December 2021, symptomatic patients who underwent 3.0 T MR SWI were recruited. For study group, transfemoral cerebral angiography-proven lesions were included, while 1:1 matched control group with MR angiography were included. Image features of SWI were evaluated. Diagnostic performance and interobserver agreements were calculated for detecting VAD with stenosis and UIA greater than 7 mm. Results Total of 110 patients (mean age: 60.92 years, female: 60/110) were included. In the study group (N = 55), 21 patients (38.2%) had VAD, while 34 patients (61.8%) had UIA. For SWI-detectable VAD, larger parent artery (PA)-dilatation ratio was observed (1.36 vs. 1.84, p = 0.034). For SWI-detectable UIA, larger PA-dome ratio (1.32 vs. 1.90, p = 0.020) and larger PA-height ratio (1.25 vs. 1.77, p = 0.005) were observed. The diagnostic performance and kappa values for VAD with stenosis were as follow: sensitivity: 91.7 (95% CI: 61.5–99.8); specificity: 93.9 (95% CI: 87.2–97.7); к: 0.80. The diagnostic performance for UIA larger than 7 mm were as follow: sensitivity: 87.5 (95% CI: 47.4–99.7); specificity: 95.1 (95% CI: 88.9–98.4); к: 0.73. Conclusion SWI-detectable lesions were VAD with larger PA-dilatation ratio, and UIA with larger PA-dome ratio, and PA-height ratio. SWI was able to accurately detect VAD with stenosis and UIA larger than 7 mm with substantial interobserver agreements.
Promoting evidence-based nursing through journal clubs: an integrative review
Authors: Valizadeh Leila , Zamanzadeh Vahid , Alizadeh Samaneh , Namadi Vosoughi Maryam 
Published: June 2022

Background The journal club has been proposed as a tool to fill the gap between theory and practice. Aim The present research is an integrative review of studies focussing on journal clubs. Methods An integrative review. We searched the databases during 2010–2019 to find papers using the keywords journal club, nursing, evidence-based practice. The modified version of Cooper’s five-stage integrative review was applied. Results The results are presented in two sections – the benefits and challenges of nursing journal clubs and an outline of presentation guidelines. We also discuss the effectiveness of journal clubs in the promotion of evidence-based nursing. Conclusions The purpose of the nursing journal club is to review existing literature, discuss the latest information and evidence and identify practical changes required to ultimately improve patient outcomes. Further studies are needed to evaluate the effectiveness of journal clubs in patient care.
Septic arthritis of the wrist: a retrospective review of 39 cases
Authors: Krauss Sabrina , Denzinger Markus , Rachunek Katarzyna , Kolbenschlag Jonas , Daigeler Adrien , Illg Claudius 
Published: June 2022

We retrospectively analysed characteristics of 39 patients who presented with septic arthritis of the wrist between January 2015 and June 2021. There was a significant positive correlation between the number of risk factors, such as immunosuppression or diabetes, with Pseudomonas arthritis but not with the number of operations needed to treat the infection or the length of hospitalization. The duration of symptoms before admission at our hospital, C-reactive protein values at admission and infection with Pseudomonas were significantly correlated with the length of hospitalization, but Pseudomonas was detected in one patient only. Staphylococci were the most frequently detected bacteria and significantly correlated with the number of operations needed for treatment. Normal white blood cell counts or C-reactive protein values were frequently encountered. Level of evidence III
Abductor pollicis brevis rerouting and first web deepening for clasped thumb deformity in arthrogryposis multiplex congenita
Authors: Anbarasan Amaleswaran , Takagi Takehiko , Seki Atsuhito , Takayama Shinichiro 
Published: June 2022

In this study, we retrospectively reviewed our results of managing the clasped thumb deformity in arthrogryposis multiplex congenita patients with first web space deepening and abductor pollicis brevis (APB) rerouting. Twenty-six thumb deformities in 16 children with a mean age of 6.2 years were treated with a mean follow-up of 89.6 months. Following reconstruction with the Spinner flap, the mean angle of the first and second metacarpal axis (M1M2) showed significant improvement from 42° to 61° indicating a wider first web space, and the postoperative mean angle of the thumb proximal phalanx to its metacarpal axis (M1P1) was reduced from 41° to 18°, indicative of a straighter thumb. Following reconstruction with a double-opposing Z-plasty, the mean M1M2 and M1P1 also improved from 38° to 52° and 18° to 9°, respectively. Rerouting of the APB with first web deepening is an efficient and reproducible procedure in improving thumb position. Level of evidence III
The consequences of the COVID-19 pandemic on the refugee population: a rapid review
Authors: Badanta B , González-Cano-Caballero M , Fernández-García E , Lucchetti G , de Diego-Cordero R 
Published: June 2022

Aims: This is a rapid review examining the available evidence about the repercussions of the COVID-19 pandemic on the refugee population. Methods: A search in the databases such as PubMed, Scopus, CINAHL, PsycINFO, and Web of Science was conducted and all relevant original articles, letters, and editorial and policy papers were included. Results: From 208 publications matching the search criteria, 36 were included. These publications were categorized into three distinct domains: Public Health, Policies and Financing, and Technology. Our findings revealed that the situation of the refugee population has worsened during the pandemic. Difficulty accessing healthcare, violation of human rights, lack of access to technology devices, unfavorable government policies, and economic crisis were the most important aspects impacted by COVID-19. Conclusion: Governments, health managers, health professionals, and policy makers should be aware of refugees’ problems during the pandemic to provide immediate solutions.
Retrospective Case Control Study: Clinical and Computer Tomographic Fusion and Subsidence Evaluation for Single Level Uniportal Endoscopic Posterolateral Approach Transforaminal Lumbar Interbody Fusion Versus Microscopic Minimally Invasive Transforaminal Interbody Fusion
Authors: Kim Hyeun Sung , Wu Pang Hung , Kim Ji Yeon , Lee Jun Hyung , Lee Yeon Jin , Kim Dae Hwan , Lee Jun Hyung , Jeon Jun Bok , Jang Il-Tae 
Published: June 2022

Study Design: Retrospective comparative study. Objective: Assessment of difference in clinical and computer tomographic outcomes between the 2 cohorts. Methods: Computer tomographic evaluation by Bridwell’s grade, Kim’s stage, Kim’s subsidence grade and clinical evaluation by VAS, ODI and McNab’s criteria on both cohorts. Results: 33 levels of Endo-TLIF and 22 levels of TLIF were included, with a mean follow up of 14.3 (10-24) and 22.9 (13-30) months respectively. Both Endo-TLIF and TLIF achieved significant improvement of pain and ODI at post-operative 4 week, 3 months and at final follow up with VAS 4.39 ± 0.92, 5.27 ± 1.16 and 5.73 ± 1.21in Endo-TLIF and 4.55 ± 1.16, 5.05 ± 1.11 and 5.50 ± 1.20 in TLIF respectively and ODI at post-operative 1 week, 3 months and final follow up were 43.15 ± 6.57, 49.27 ± 8.24 and 51.73 ± 9.09 in Endo-TLIF and 41.73 ± 7.98, 46.18± 8.46 and 49.09 ± 8.98 in TLIF respectively, P < 0.05. Compared to TLIF, Endo-TLIF achieved better VAS with 0.727 ± 0.235 at 3 months and 0.727 ± 0.252 at final follow up and better ODI with 3.88 ± 1.50 at 3months and 3.42 ± 1.63 at final follow up, P < 0.05. At 6 months radiological evaluation comparison of the Endo-TLIF and TLIF showed significant with more favorable fusion rate in Endo-TLIF of −0.61 ± 0.12 at 6 months and −0.49 ± 0.12 at 1 year in Bridwell’s grading and 0.70 ± 0.15 at 6 months and 0.56 ± 0.14 at 1 year in Kim’s stage.There is less subsidence of 0.606 ± 0.18 at 6 months and −0.561 ± 0.20 at 1 year of Kim’s subsidence grade, P < 0.05. Conclusion: Application of single level uniportal endoscopic posterolateral lumbar interbody fusion achieved better clinical outcomes and fusion rate with less subsidence than microscopic minimally invasive transforaminal lumbar interbody fusion in mid-term evaluation for our cohorts of patients.
Reducing the Risk of Neurovascular Injury With Posteromedial Plating and Laterally Directed Screw Insertion During Opening-Wedge High Tibial Osteotomy
Authors: Shim Seung Jae , Jeong Ho Won , Park Sung Bae , Lee Yong Seuk 
Published: June 2022

Background: Neurovascular injury is a serious complication after opening-wedge high tibial osteotomy (OWHTO). Purpose: To evaluate (1) how neurovascular injuries during fixation can be prevented and (2) whether a lateral hinge–directed posteromedial fixation system provides comparable neurovascular safety during OWHTO to conventional and custom-made locking plate systems. Study Design: Cohort study; Level of evidence, 3. Methods: Included were 275 knees that underwent OWHTO from March 2014 to May 2018. The knees were divided into 4 groups based on the type of fixation system used: (1) lateral hinge–directed system (LCfit HTO; LCfit group), (2) TDM decisive wedge locking plate (TDM group), (3) OhtoFix anatomic locking metal block plate (OhtoFix group), and (4) TomoFix titanium locking plate (TomoFix group). Using postoperative computed tomography, the following variables among the groups were compared: screw insertion angle relative to the tibia posterior cortex in the axial plane, length, proximity to neurovascular structures, and safety angle of screw fixation (angle between the most proximal posterior screw insertion line and a line tangent to the popliteal artery from the screw hole). Radiological and clinical outcomes were also compared between groups. Results: The screw angle was significantly smaller and the distance from neurovascular structures to the screw extension line was significantly farther in the LCfit group compared with the other 3 groups ( P < .001 for both). The safety angle was also wider in the LCfit group than in the other groups ( P < .001). There were no significant differences in radiologic or clinical outcomes between the groups during follow-up. Conclusion: The distance from the neurovascular structures to the screw extension line was significantly farther, and the safety angle was also significantly wider with the laterally directed posteromedial plate system compared with the other systems. There were no neurovascular injuries in any group or significant differences in clinical outcomes or radiological parameters between the LCfit and the other locking plate systems.
Statistical Analysis Plan for the Secondary Prevention by Structured Semi-Interactive Stroke Prevention Package in INDIA (SPRINT INDIA): A Randomized Controlled Trial
Authors: Khatter Himani , Pandian Jeyaraj D. , Kate Mahesh , Sarma Sankara , Sylaja PN , Khurana Dheeraj , Vijaya Pamidimukkala , Ray Biman Kanti , Nambiar Vivek , Aaron Sanjith , George Tina , Mittal Gaurav , Sebastian Ivy , Sundarachary Nagarjunakonda V. , Pai Aparna R. , Gorthi Sankar , Somasundaram Kumaravelu , Sharma Meenakshi , Dhaliwal Rupinder , Reddy Y. Muralidhar , Narayan Sunil , Borah NC , Das Rupjyoti , Kulkarni Girish B. , Huded Vikram , Mathew Thomas , Srivastava Padma MV , Bhatia Rohit , Ojha Pawan , Roy Jayanta , Abraham Sherly , Webster Jemin , Vaishnav Anand , Sharma Arvind , Jabeen Shaik A. , Pathak Abhishek , Bhoi Sanjeev , Sharma Sudheer , Sulena Sulena , Saroja Aralikatte Onkarappa , Ramrakhiani Neetu , Kempegowda Madhusudhan B. , Arora Deepti , Verma Shweta J. , Huilgol Rahul , Dasan Aneesh , Renjith Vishnu 
Published: June 2022

Background: Recurrent stroke is one of the major causes of death in stroke patients. Introducing stroke prevention education package to improve the lifestyle behavioral factors could reduce the vascular events. The Secondary Prevention by Structured Semi-Interactive Stroke Prevention Package (SPRINT) study in India aims to assess the role of a stroke prevention education package to reduce recurrent strokes, myocardial infarction, and death in patients with stroke. The objective is to formulate the detailed statistical analysis plan for the SPRINT India prior to trial unblinding. Methods: The plan was developed by trial statisticians with the help of principal investigator and management team of the SPRINT study. The chosen primary and secondary outcome measures and knowledge of critical baseline data were used to construct the statistical analysis plan. All collected data will be thoroughly reviewed. Patient baseline characteristics will be summarized with relevant descriptive statistics. The findings are planned and explained for the most appropriate statistical comparison between the groups. Results: The final statistical analysis plan corresponds to established criteria and will allow for transparent and efficient reporting. Conclusions: The SPRINT trial statistical analysis plan is developed in order to avoid analysis bias arising from prior knowledge of findings and to explicitly summarize prespecified analyses.
Transcriptome analysis reveals the accelerated expression of genes related to photosynthesis and chlorophyll biosynthesis contribution to shade-tolerant in Phoebe bournei
Authors: An Jing , Wei Xiaoli , Huo Honghao 
Published: June 2022

Abstract
Background
Phoebe bournei (P. bournei) is an important and endemic wood species in China. However, the plantation, nursing, and preservation of P. bournei are often affected by light. To investigate its physiological changes and molecular mechanism of low light tolerance, two-year-old P. bournei seedlings were subjected to different shading conditions. With the increase of light intensity in the shade, the leaf color of P. bournei seedlings became darkened, the aboveground/underground biomass significantly increased, the content of chlorophyll increased and the net photosynthetic rate significantly increased.

Results
de novo transcriptome analysis showed that 724 and 3,248 genes were differentially expressed due to low light intensity at T1 (35% light exposure) and T2 (10% light exposure), respectively, when compared to the controls. Furthermore, the differentially expressed genes (DEGs) were implicated in photosynthesis, nitrogen metabolism, plant hormone signal transduction, biosynthesis of secondary metabolites, and protein processing in the endoplasmic reticulum by functional enrichment analysis. Moreover, the expression of HSP, CAB, HEMA1, GSA, DVR, MYB, bHLH, PORA, CAO, GLK, and photosystem I and II complex-related genes significantly increased after low light exposure at T2 and T1.

Conclusions
The present study suggests that the rapid growth of P. bournei seedlings under shading conditions may be the result of the accelerated expression of genes related to photosynthesis and chlorophyll biosynthesis, which enable plants to maintain a high photosynthesis rate even under low light conditions.
I-125 seeds brachytherapy with transcatheter arterial chemoembolization for subcapsular hepatocellular carcinoma
Authors: Gao Fu-Lei , Wang Yong , Huang Xiang-Zhong , Pan Tian-Fan , Guo Jin-He 
Published: June 2022

AbstractBackgroundI-125 seeds brachytherapy (ISB) has been used to improve the clinical effectiveness of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). We aim to appraise the safety and clinical efficacy of combined ISB and TACE for the treatment of subcapsular HCC.Materials and methodsA retrospective investigative study extending from January 2017 to December 2020, involved individuals suffering from subcapsular HCC, who were subjected to TACE treatment with or without ISB in our center. The clinical effectiveness was compared between 2 groups.ResultsSixty-four patients, in total, with subcapsular HCC had to undergo TACE with (n = 32) or without (n = 32) ISB in our center. After CT-guided ISB, only 2 (6.3%) patients experienced a self-limited pneumothorax. Combined treatment resulted in a significantly higher complete response (56.3% vs. 18.8%,P = 0.002) and total response (90.7% vs. 59.4%,P = 0.004) rates than that of TACE alone. In comparison to the TACE alone group, the median progression-free survival was substantially longer in the combined treatment group (11 months vs. 5 months,P = 0.016). Further, 15 and 28 patients in combined and TACE alone groups respectively died within the follow-up. The median OS was comparable between combined and TACE alone groups (22 months vs. 18 months,P = 0.529).ConclusionsCombined TACE and ISB therapy is a safe treatment method for individuals suffering from subcapsular HCC. When compared, combined treatment had significantly enhanced clinical efficacy as a subcapsular HCC therapy, in comparison to TACE alone.