bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eating Disorders and Intimate Partner Violence: The Influence of Fear of Loneliness and Social Withdrawal
Authors: Momeñe Janire , Macía Patricia , Estévez Ana , Griffiths Mark D. , Olave Leticia , Iruarrizaga Itziar 
Published: February 2022

Abstract
Eating disorders are vulnerability factors that increase the likelihood of intimate partner violence. However, the mechanisms underlying this relationship are unclear. Although eating disorders have been associated with increased perception and fear of loneliness, they have also been associated with increased social withdrawal resulting from decreased enjoyment of social situations and poorer social functioning. The purpose of the present study was to examine the mediating role of fear of loneliness in the relationship between the behavioural characteristics of eating disorders and intimate partner violence, as well as to explore the moderating role of social withdrawal in the relationship between fear of loneliness and intimate partner violence. The sample comprised 683 participants (78% female and 22% male) with a mean age of 21.14 years (SD = 2.72). The hypothesized model was tested by path analysis using maximum likelihood. The path analysis of the hypothesized model showed that inefficacy, fear of maturity, and impulsivity were the behavioural characteristics of eating disorders predominantly related to fear of loneliness. Fear of loneliness had no direct significant effect on any of the received violence variables. However, interaction effects indicated that there was a moderately significant effect of fear of loneliness on physical, psychological, and social violence received as a function of levels of social withdrawal. These findings show the need to take into account and work on fear of loneliness and social withdrawal among individuals with an eating disorder to decrease the likelihood of establishing violent intimate partner relationships. Improving interpersonal functioning and social support is key to recovery from eating disorders.
Saliva as Alternative to Naso-Oropharyngeal Swab for SARS-CoV-2 Detection by RT-qPCR: A Multicenter Cross-Sectional Diagnostic Validation Study
Authors: Tee Michael L. , Abrilla Aedrian A. , Tee Cherica A. , Dalmacio Leslie Michelle M. , Villaflor Vivencio Jose P. , Abubakar Al-Zamzam A. , Tagayuna Pedrito Y. , Aquino Sheldon Steven C. , VI Vicente Aaron L. Bernardo , Matias Ronald R. 
Published: February 2022

Abstract
Saliva has been demonstrated as feasible alternative to naso-oropharyngeal swab (NOS) for SARS-CoV-2 detection through reverse transcription quantitative/real-time polymerase chain reaction (RT-qPCR). This study compared the diagnostic agreement of conventional NOS, saliva with RNA extraction (SE) and saliva direct without RNA extraction (SalivaDirect) processing for RT-qPCR in identifying SARS-CoV-2. All techniques were also compared as separate index tests to a composite reference standard (CRS) where positive and negative defined as SARS-CoV-2 detection in either one and no sample, respectively. Of 518 paired samples, SARS-CoV-2 was detected in 150 (28.96%) NOS and 151 (29.15%) saliva specimens. The saliva-based tests were noted to have a sensitivity, specificity and accuracy (95% confidence interval) of 92.67% (87.26%, 96.28%), 97.55% (95.41%, 98.88%) and 96.14% (94.10%, 97.63%), respectively, for SE RT-qPCR and 90.67% (84.84%, 94.80%), 98.91% (97.24%, 99.70%) and 96.53% (94.56%, 97.93%), respectively, for SalivaDirect RT-qPCR compared to NOS RT-qPCR. Compared to CRS, all tests demonstrated diagnostic performance that is statistically similar to each other. These suggest that both conventional and streamlined saliva RT-qPCR are non-inferior to conventional NOS RT-qPCR in detecting SARS-CoV-2.
Oryza nivara allele of a major effect QTL qFLA1.1 increases flag leaf area in rice
Authors: Guttikonda Haritha , Chandu Gowthami , Munnam Suchandranath Babu , Beerelli Kavitha , Balakrishnan Divya , Ragimasalawada Madhusudhana , Sarla N 
Published: February 2022

Abstract
A stable back cross introgression line IL65 (IET22161) (Swarna/O. nivara-BC2F6) of rice was used to map flag leaf related traits in F2 and F3. A total of 12 QTLs were mapped for flag leaf related traits on two chromosomes with each QTL explaining 3 to 21% phenotypic variance (PV). Interestingly, a novel 12Mb QTL cluster (RM8094 - RM9) that controls 7 traits was identified on long arm of chromosome 1 where QTLs qSPAD1.2, qSPAD1.3 for SPAD, qFLL1.1, qFLL1.2 for flag leaf length, qFLW1.1, qFLW1.2 for flag leaf width, qFLA1.1, qFLA1.2 for flag leaf area, qPH1.1, qPH1.2 for plant height, qDTF1.2, qDTF1.3 for days to flowering and qHI1.2, qHI1.3 for harvest index were co-located. Among these, one major effect QTL qFLA1.1 for flag leaf area was identified in a 9Mb region between RM8094 and RM5638. There was an adjacent minor effect QTL qFLA1.2 in a 3Mb region between RM5638 and RM9. Together these two QTLs and with leaf area increasing QTL allele from O. nivara explained 19.7% PV. The QTL for flag leaf related traits can be fine mapped and considered for breeding rice varieties with higher flag leaf area, photosynthetic rate and grain yield.
A Refined Injury and Modular Dietary Design for Studying Atherogenesis in Rabbits: The Next Level in Deciphering the Interplay of Risk Factors
Authors: Almer Gunter , Opriessnig Peter , Wolinski Heimo , Sommer Gerhard , Diwoky Clemens , Lechleitner Margarete , Kolb Dagmar , Bubalo Vladimir , Brunner Markus , Schwarz Andreas , Leitinger Gerd , Schoiswohl Garbriele , Marsche Gunther , Niedrist Tobias , Schauer Silvia , Oswald Wolfgang , Groselj-Strele Andrea , Paar Marget , Cvirn Gerhard , Hoefler Gerald , Rechberger Gerald , Herrmann Markus , Frank Sasa , Holzapfel Gerhard , Kratky Dagmar , Mangge Harald , Hörl Gerd , Tehlivets Oksana 
Published: February 2022

Abstract
Atherosclerosis is the leading cause of cardiovascular disease, which is responsible for the majority of deaths worldwide. Lack of reproducible and controlled induction of atherosclerotic lesions in preclinical animal models limits atherosclerosis research. Here, we developed the first automated system for vessel wall injury that leads to more homogenous damage and more pronounced atherosclerotic plaque development at low balloon pressure in a rabbit model of atherosclerosis, and used this system to investigate the risk factor interplay. Elevated plasma homocysteine is an independent risk factor for atherosclerosis and is strongly linked to cardiovascular mortality. Already in the absence of hypercholesterolemia, deficiency in vitamins and choline required for homocysteine metabolization results in atherogenic transformation of the aorta i.e. impairment of its biomechanical properties, alteration of collagen organization as well as macrophage and lipid accumulation, and aggravation of atherosclerosis including significantly altered water diffusion and impaired vascular reactivity in its presence.
In-Resin CLEM of Epon-Embedded Cells Using Proximity Labeling
Authors: Sanada Takahito , Yamaguchi Junji , Furuta Yoko , Kakuta Soichiro , Tanida Isei , Uchiyama Yasuo 
Published: February 2022

Abstract
Biotin ligases have been developed as proximity biotinylation enzymes for analyses of the interactome. However, there has been no report on the application of proximity labeling using biotin ligase for in-resin correlative light-electron microscopy of Epon-embedded cells. In this study, we established a proximity-labeled in-resin CLEM of Epon-embedded cells using miniTurbo, a biotin ligase. Biotinylation by miniTurbo was observed in cells within 10 mins following the addition of biotin to the medium. Using fluorophore-conjugated streptavidin, intracellular biotinylated proteins were labeled after fixation of cells with a mixture of paraformaldehyde and glutaraldehyde. Fluorescence of these proteins was resistant to osmium tetroxide staining and was detected in 100-nm ultrathin sections of Epon-embedded cells. Ultrastructures of organelles including mitochondria and endoplasmic reticulum were preserved well in the same sections. Fluorescence in sections was about 14-fold brighter than that in the sections of Epon-embedded cells expressing mCherry2 and was detectable for 14 days. When mitochondria-localized miniTurbo was expressed in the cells, mitochondria-like fluorescent signals were detected in the ultrathin sections, and ultrastructures of mitochondria were observed as fluorescence-positive structures in the same sections by scanning electron microscopy. These results indicated that in-resin correlative light-electron microscopy of Epon-embedded cells using proximity labeling was achieved.
A novel nomogram predicting the overall survival of metastatic non–clear cell renal cell carcinoma patients: a large population-based investigation
Authors: Wu Jie , Shang Bingqing , Xie Ruiyang , Cao Chuanzhen , Shi Hongzhe , Shou Jianzhong , Guan Youyan 
Published: February 2022

Abstract
Objective: Metastatic non–clear cell renal cell carcinoma (non-ccmRCC) is the end stage of this disease with a poor prognosis. This study aimed to investigate prognostic clinicopathological factors and develop nomogram models for non-ccmRCC patients using a large population-based cancer database. Methods and materials: Data of all patients with non-ccmRCC from 2010 to 2015 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database and analyzed retrospectively. Cox regression models were used to analyze prognostic risk factors for overall survival (OS). Prognostic nomogram was carried out with R software to predict the OS probability. The validation of the nomogram was performed using calibration curves and receiving operating characteristic (ROC) curve. Results: A total of 776 non-ccmRCC patients in the SEER database were included. We separated non-ccmRCC patients into three groups (group 1: one, group 2: two, group 3: three or more) according to the number of metastatic organs. Age, histology, T stage, N stage, number of metastatic organs, surgery, and chemotherapy were independent risk factors, and hence integrated into the models. The calibration curves for 6-, 12-, and 18-month OS suggested perfect agreement between the prediction by nomogram and the actual survival outcome. The 6-, 12-, and 18-month AUC of the nomogram based on the time-dependent ROC curve analysis were 0.784, 0.754, and 0.766, respectively. The result demonstrated the promising prognostic value of the nomogram. Conclusions: We performed the first accurate nomogram for OS prediction of non-ccmRCC patients, which might help clinicians in treatment decision making.
Study on the calculation and distribution of value-added benefits between regional industries water rights transaction
Authors: Zhang Wenge , Du Qiongying , Guan Xinjian , Wang Baoyong 
Published: February 2022

Abstract
As an important means of optimizing the allocation of water resources, the continuous development of water rights transaction has a stronger demand for fair distribution of benefits among participants. In this paper, the marginal benefit of agricultural and industrial water is calculated based on the Cobb-Douglas production function, and the benefit increment of water rights trade from agriculture to industry is calculated based on the tradable water volume. Meanwhile, the improved Shapley value method is used to distribute benefits between regional industries, which considers the impact of investment factors and risk factors on the distribution of benefits compared with the traditional Shapley value method. Taking Ordos City in Inner Mongolia as an example, the calculation results show that the marginal benefit of industrial water is 157.94 RMB/m³, which is far greater than the marginal benefit of agricultural water of 4.27 RMB/m³, and the water right trade improves the use value of water resources. The improved Shapley value method can allocate 39.058 hundred million RMB and 97.032 hundred million RMB to agriculture and industry respectively, which improves the allocation weight of industry compared with the original Shapley value method. The study on the increment and distribution of the benefits of water rights transaction between regional industries proposed in this paper, can provide a reference for the income distribution of all parties in the practice of water rights transactions and promote the sustainable development of water rights transactions.
Polarization and Wide Incident Angle Insensitive Metal Free Superwideband Absorber For Terahertz and Infrared Spectrum
Authors: Singhal Sarthak 
Published: February 2022

Abstract
A circular slot loaded octagonal metal free graphite based absorber for superwideband applications at terahertz and infrared spectrum is proposed. The absorber comprises a circular slot loaded octagonal graphite slab at the top layer, silicon dioxide as substrate and square graphite slab as the bottom layer. This absorber is operating over a frequency spectrum of 6 THz to more than 80 THz (ratio bandwidth of > 12:1 and fractional bandwidth of >172.093%) for absorption more than 90% with unity peak absorption. The absorber dimensions are 5 µm × 5 µm × 7.04 µm. The thickness of the substrate is only ∼ λo/26 and the periodicity of absorber is ∼ λo/10 at 6 THz. The performance of the absorber is found to be insensitive to changes in polarization angle (Φ). Furthermore, the performance of the absorber is observed to be unaffected by incident angle (θ) variations from 0o to 60o. The metal-free geometry along with insensitiveness to Φ and 0o ≤ θ ≤ 60o makes the proposed absorber suitable for compact terahertz/infrared micro/nanoscale systems.
Conflicts and Ethical Dilemmas in Times of the Covid 19 Pandemic
Authors: TOIA AGUEDA MUÑOZ DEL CARPIO , Valenti Emanuele , Torres Fernando , Dávila Luis Manuel López , Carpio Lucia Begazo Muñoz del , Carrera Enrique Mendoza 
Published: February 2022

Abstract
Background: Throughout the Pandemic caused by COVID-19, health professionals have faced the fight against this disease in the front line, even without effective treatment, this uncertainty led to the presentation of various ethical crises in health services to be analyzed. Methods: An exploratory, cross-sectional investigation was developed, for which a self-application instrument was designed, in the online interview modality, aimed at doctors and university professors involved with bioethics with the purpose of analyzing ethical aspects in care of COVID-19 patients.Results: 100 interviews were collected for the convenience of their work location, 67% worked in hospitals, 11% in clinics, and 22% in universities teaching the bioethics course. Problematic situations related to high exposure to risks of health professionals, infrastructure gap, ICU beds, and hospital beds were identified as problematic situations. The main conflicts and ethical dilemmas were related to decision-making for the allocation of resources, lack of culture of self-care for the health of the population, the risk of contagion from the doctor, therapies not supported by clinical trials, and patient-physician prioritization. Conclusions: It was evidenced that university doctors and teachers identified various problematic situations, conflicts and ethical dilemmas in the care of COVID-19 patients, which compromise ethical values of maximization of benefits, equity, in addition to ethical principles such as beneficence, justice, reciprocity, solidarity, integrity, respect, vulnerability, dignity, damaging their human and legal rights.
Primary Intracranial Ewing Sarcoma/peripheral primitive neuroectodermal tumor: A Case Report
Authors: 罗 世刚 , wang feifei , huang huan , Tang GuangCai 
Published: February 2022

Abstract
Background: Primary intracranial Ewing sarcoma/peripheral primitive neuroectodermal tumor (EW S/pPNET) is exceedingly rare; and easy to misdiagnose.Case presentation: We report a case of a 23-year-old male who presented with headache and vomiting. The preoperative imaging examination of the brain revealed an irregular mass in the left parietal lobe, which was misdiagnosed as a meningioma, but the surgical specimen was diagnosed as primary intracranial EWS/pPNET. The patient underwent a total tumor resection, followed by adjuvant chemotherapy and radiotherapy. No recurrence or distant metastasis was found 18 months post-surgery. In addition, the clinical manifestations and treatment prognosis of primary intracranial EWS/pPNET were explored through a literature review.Conclusions: When the imaging features of young patients’ lesions are solid, aggressive, and unevenly enhanced masses, physicians should be aware of the possibility of primary intracranial EWS/pPNET, and if possible, gross total resection (GTR) and intensive chemotherapy and radiotherapy are recommended.
Rare Occurrence of Pseudomyxoma Peritonei (PMP) Syndrome Arising from a Malignant Transformed Ovarian Primary Mature Cystic Teratoma Treated by Cytoreductive Surgery and HIPEC: A Case Report
Authors: Ponzini Francesca M. , Kowal Luke L. , Ghafoor Mariam , Goldberg Allison , Chan Joanna , Lamm Ryan , Cannaday Shawnna M. , Richard Scott D. , Nevler Avinoam , Lavu Harish , Bowne Wilbur B. , Rosenblum Norman G. 
Published: February 2022

Abstract
Background: Pseudomyxoma peritonei (PMP) syndrome is a disease process that typically occurs from ruptured appendiceal mucocele neoplasms. PMP syndrome arising from malignant transformation of an ovarian primary mature cystic teratoma (MCT) is a pathogenesis rarely encountered. Case Presentation: Herein, we report a twenty-eight-year-old patient evaluated and treated for a right ovarian mass and large volume symptomatic abdominopelvic mucinous ascites. Molecular profiling and genetic analysis revealed mutations in ATM, GNAS, and KRAS proteins while IHC demonstrated gastrointestinal specific staining for CK20, CDX2, CK7 and SATB2. Peritoneal cytology showed paucicellular mucin. Diffuse peritoneal adenomucinosis (DPAM) variant of PMP arising from a ruptured ovarian primary MCT after malignant transformation to a low grade appendiceal-like mucinous neoplasm was ultimately confirmed. Treatment included staged therapeutic tumor debulking and right salpingo-oophorectomy followed by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). Conclusions: Our report builds upon the existing literature supporting this aggressive treatment option reserved for advanced abdominal malignancies utilized in this patient with a rare clinical entity.
COVID-19 Breakthrough Infections among Patients with Cancer Receiving Sinopharm BIBP Vaccine
Authors: Manteghinejad Amirreza , Arabzadeh Saeedeh , Rezaian Zahra , Sharifi Mehran , Javanmard Shaghayegh Haghjooy 
Published: February 2022

Abstract
Background:Patients with cancer are at an increased risk of mortality from COVID-19 infection. So, they are prioritized for vaccination. This study aims to report the clinical characteristics of patients who had a positive PCR test after being fully vaccinated by Sinopharm BIBP Vaccine.Methods:In this retrospective study, the data of patients with cancer were extracted from the electronic health records of a cancer center from Isfahan, Iran. All COVID-19 data of Isfahan province also was collected by Isfahan COVID-19 Registry. We describe the clinical characteristics of patients with cancer who have a positive test >14 days after the second dose.Results:Two hundred twenty-two cancer patients had at least one positive PCR test after the start of the COVID-19 vaccination. Of these, 9(4.1%) breakthrough infections have occurred. Six (67%) of them have hematological malignancies. Six(67%) were hospitalized. Three(33%) of patients died. Two of them had recent chemotherapy and have hematological malignancies.Conclusion:Vaccination is a good way to protect the populations from COVID-19 complications and mortality, but it should be considered that fully-vaccinated cancer patients are at risk of severe outcomes. Nevertheless, prioritizing cancer patients, especially those with hematological malignancies, or receiving chemotherapies for booster vaccines and studying the effectiveness of each COVID-19 vaccine for cancer patients should be considered.
Bimodal Distribution of Thyroid Dysfunction Triggered by Covid-19 Infection. An Experience From a Single Endocrine Centre. A Short Report &amp; Literature Review
Authors: Elhadd Tarik A , Gul Wajiha , Dabbous Zeinab , Beer Stephen , Bashir Mohammed 
Published: February 2022

Abstract
Purpose: Covid-19 infection has been spreading across the globe since the end of 2019 and it continues to cause chronic multi-system sequalae, of which thyroid dysfunction appears to be a major one. We aim to present casesMethods: Case series report.Results: Over the period from October 2020 to July 2021, a series of 10 cases of thyroid dysfunction due to Covid-19 infection were seen and managed in a single outpatient endocrine centre in Doha, Qatar. These are 6 cases of Graves hyperthyroidism, two cases of chronic primary hypothyroidism including one with GD treated by RAI therapy, two cases of subacute thyroiditis and one case with ‘Thyroxin Thyrotoxicosis’, and finally one case of central hypothyroidism. Conclusion: This report is the largest to be reported from a single centre so far, and it points to a bimodal distribution of thyroid dysfunction in patients with covid-19 infection. A review of the literature and discussion of possible pathophysiological mechanisms is presented. We stress the importance of screening for thyroid dysfunction in post-Covid cases, as the prevalence may be underestimated.
Concerns among People who use Opioids during the COVID-19 Pandemic: A Natural Language Processing Analysis of Social Media Posts
Authors: Sarker Abeed , Nataraj Nisha , Siu Wesley , Li Sabrina , Jones Christopher M. , Sumner Steven A. 
Published: February 2022

Abstract
Background:
Timely data from official sources regarding the impact of the COVID-19 pandemic on people who use prescription and illicit opioids (PWUOs) is lacking. We conducted a large-scale, natural language processing (NLP) analysis of conversations on opioid-related drug forums to better understand concerns among PWUOs.
Methods:
In this retrospective observational study, we analyzed posts from 14 opioid-related forums on the social network Reddit. We applied NLP to identify frequently mentioned substances and phrases, and grouped the phrases manually based on their contents into three broad key themes: (i) prescription and/or illicit opioid use; (ii) substance use disorder treatment access and care; and (iii) withdrawal. Phrases that were unmappable to any particular theme were discarded. We computed the frequencies of substance and theme mentions, and quantified their volumes over time. We compared changes in post volumes by key themes and substances between pre-COVID-19 (1/1/2019—2/29/2020) and COVID-19 (3/1/2020—11/30/2020) periods.
Results:
77,652 and 119,168 posts were collected for the pre-COVID-19 and COVID-19 periods, respectively. By theme, posts about treatment and access to care increased by 300%, from 0.631 to 2.526 per 1000 posts between the pre-COVID-19 and COVID-19 periods. Conversations about withdrawal increased by 812% between the same periods (0.026 to 0.235 per 1,000 posts). Posts about drug use did not increase (0.219 to 0.218 per 1,000 posts). By substance, among medications for opioid use disorder, methadone had the largest increase in conversations (20.8 to 56.3 per 1,000 posts; 171.4% increase). Among other medications, posts about diphenhydramine exhibited the largest increase (0.3 to 0.9 per 1,000 posts; 171.8% increase).
Conclusions:
Conversations on opioid-related forums among PWUOs revealed increased concerns about treatment and access to care along with withdrawal following the emergence of COVID-19. Greater attention to social media data may help inform timely responses to the needs of PWUOs during COVID-19.