bluuebunny/crossref_metadata_2025_split huggingface dataset:
806 Foot burns in diabetic patients: A systematic review
Authors: Choi Katherine J , Pham Christopher H , Sheckter Clifford C , Collier Zachary J , Yenikomshian Haig A , Garner Warren L , Gillenwater Justin 
Published: March 2022

Abstract

Introduction
Patients with diabetes are prone to foot injuries and burns. Managing burned feet in patients with diabetes can be difficult due to multiple concomitant patient comorbidities that delay wound healing. Burn surgeons tasked with treating these complex foot burns understand that these patients are at risk of developing significant complications, such as infections and non-healing diabetic foot ulcers, which may ultimately lead to amputation. Although there are many studies that examine the causes and outcomes of diabetic foot ulcers and their management, there is a lack of consensus on how to best manage lower extremity burns in patients with diabetes.

Methods
A systematic review was performed according to PRISMA criteria and identified 18 articles addressing the management of burned feet in patients with diabetes. Means and standard deviations of scale variables and frequencies derived from nominal and ordinal variables abstracted from the literature were compared between each group. A meta-analysis was attempted but existing data was not of sufficient quality for meaningful analysis, and data aggregation was done where applicable.

Results
The three-database search identified 726 articles, which yielded 18 full text articles that met inclusion criteria. mean age of patients was 54 years (SD 7), and 80% (n=203) were male. Most (90%, n=179) had type II diabetes, and 10% (n=20) had Type I diabetes. Mean duration of diabetic disease was 11 years (SD 4), and mean A1c at admission was 9% (SD 1). Peripheral neuropathy (64%, n=123) was the most common comorbidity. Median TBSA burned was 2% (IQR 2), and scald (56%, n=155) was the most common mechanism of injury. Full thickness burns (70%, n=102) were most common, followed by partial thickness (28%, n=41), and superficial thickness (2%, n=2). A majority (55%, n=88) had burn wound infection identified at admission. Patients had a median delay in presentation from time of injury to hospital admission of 4 days (IQR 4.5). Sixty percent of patients received surgical treatment via excision and grafting, had a median length-of-stay of 20.5 days despite a median total body surface area involvement of 2%, and experienced sequelae of impaired wound healing such as infections, graft loss, and need for further surgery. Ultimately, 23% of patients had significant wound healing issues that resulted in amputation.

Conclusions
Excision and grafting may not be the optimal approach for managing foot burns in patients with diabetes, many of whom are at high risk of amputation. Non-operative management of foot burns in patients with diabetes should be explored as a method to decrease amputations in patients with foot burns.
811 Statistical Analyses of Multiple Burn Wounds within an Animal
Authors: Grantham Lonnie E , Jockheck-Clark Angela R , Scott Laura L 
Published: March 2022

Abstract

Introduction
Porcine animal models are frequently used to study the effects of various burn wound treatments and conditions. In these studies, multiple wounds are created on the dorsum of an anesthetized pig. Wounds within an animal are correlated, and the analysis of such a design should account for this dependence. Two recent studies are used as examples to illustrate the use of random effects for animal to account for the dependence of wound measurements within each pig.

Methods
In both studies, treatments were randomized to wound location, and neither contained repeated measurements within a wound.
Study #1 investigated the effectiveness of enzymatic debridement. Forty 3-cm diameter partial-thickness burn wounds were created on the dorsum of 5 anesthetized pigs, arranged in 4 rows and 10 columns. Dorsal quadrants with 10 wounds each were created by combinations of two conditions: wounds that were wet or dry and wounds that were treated for either 72 or 96 hours. Debridement Efficiency Scores were calculated for each wound and evaluated for differences by inferential statistical comparisons between experimental treatments and conditions. The multilevel statistical model contained Treatment Group (5 levels), Treatment Time (2 levels: 72 hour and 96 hour), and Wet/Dry Condition (2 levels) as fixed effects, which were crossed to create a 3-way block, resulting in 2 wounds per animal for each Treatment, Wet/Dry, and Time combination. Random effects of animal and treatment block within animal were included in the model.
Study #2 investigated the effectiveness of an experimental treatment applied at 3 different post-burn injury time points versus a standard of care (SOC). Up to 12 5-cm2 deep partial thickness wounds were created in 2 rows and 6 columns on each dorsum of 6 anesthetized pigs. Each treated wound was compared with a SOC wound located along the same cranio-caudal axis. Paired differences for wound closure % were calculated and analyzed with time as a fixed effect with a random effect for animal.

Results
For Study #1, there were 200 total wounds, and for Study #2 there were 72 total wounds. These experimental units are not independent, as required by statistical testing. For both studies, there was graphical evidence that the burn wound measurements differed both within and between pigs. The statistical tests accounted for this variability by incorporating the effects due to pigs.

Conclusions
Matching the statistical model to the experimental design is critical for correct interpretation of the results. Failure to use the correct model by assuming wounds within a pig are independent (and thereby ignoring any effect due to the pig) will result in erroneous statistical test results and less powerful tests of treatment differences.
Grade Migration of Prostate Cancer in the United States During the Last Decade
Authors: Borregales Leonardo D , DeMeo Gina , Gu Xiangmei , Cheng Emily , Dudley Vanessa , Schaeffer Edward M , Nagar Himanshu , Carlsson Sigrid , Vickers Andrew , Hu Jim C 
Published: March 2022

Abstract

Background
Prostate cancer (PC) screening guidelines have changed over the last decade to reduce overdiagnosis and overtreatment of low-grade disease. We sought to examine and attempt to explain how changes in screening strategies have impacted temporal trends in Gleason grade group (GG) PC at diagnosis and radical prostatectomy pathology.

Methods
Using the Surveillance, Epidemiology, and End Results Registry database, we identified 438 432 men with newly diagnosed PC during 2010-2018. Temporal trends in incidence of GG at biopsy, radical prostatectomy pathology, prostate-specific antigen (PSA) level, and metastasis at diagnosis were examined. The National Health Interview Survey database was examined to evaluate trends in PSA-screening rates, and a literature review evaluating magnetic resonance imaging and biomarkers utilization during this period was performed.

Results
Between 2010 and 2018, the incidence of low-grade PC (GG1) decreased from 52 to 26 cases per 100 000 (P &lt; .001). The incidence of GG1 as a proportion of all PC decreased from 47% to 32%, and the proportion of GG1 at radical prostatectomy pathology decreased from 32% to 10% (P &lt; .001). However, metastases at diagnosis increased from 3.0% to 5.2% (P &lt; .001). During 2010-2013, PSA screening rates in men aged 50-74 years declined from 39 to 32 per 100 men and remained stable. Utilization rates of magnetic resonance imaging and biomarkers modestly increased from 7.2% in 2012 to 17% in 2019 and 1.3% in 2012 to 13% in 2019, respectively.

Conclusions
We found a significant decrease in the diagnosis and treatment of GG1 PC between 2010 and 2018. Changes in PSA screening practices appear as the primary contributor. Public health efforts should be directed toward addressing the increase in the diagnoses of metastatic PC.
Cost-effective and accurate interlaminar stress modeling of composite Kirchhoff plates via immersed isogeometric analysis and equilibrium
Authors: Patton Alessia , Carraturo Massimo , Auricchio Ferdinando , Reali Alessandro 
Published: March 2022

Abstract
The interest for composites has constantly grown in recent years, especially in the aerospace and automotive industries, as they can be moulded in complex form and geometry, as well as exhibit enhanced engineering properties. Nevertheless, despite the accelerated diffusion of laminated composites, the design of these materials is often restrained by the lack of cost-effective modeling techniques. In fact, the existing numerical strategies allowing for cheap simulations of laminated structures usually fail to directly capture out-of-plane through-the-thickness stresses, which are typically responsible for failure modes such as delamination. In this context, a stress recovery approach based on equilibrium has been recently shown to be an efficient modeling strategy in the framework of isogeometric analysis. Since immersed approaches like the finite cell method have been proven to be a viable alternative to mesh-conforming discretization for dealing with complex/dirty geometries as well as trimmed surfaces, we herein propose to extend the stress recovery approach combining the finite cell method, isogeometric analysis and equilibrium to model the out-of-plane behavior of Kirchhoff laminated plates. Extensive numerical tests showcase the effectiveness of the proposed approach.
Modeling intracellular transport and traffic jam in 3D neurons using PDE-constrained optimization
Authors: Li Angran , Zhang Yongjie Jessica 
Published: March 2022

Abstract
The intracellular transport process plays an important role in delivering essential materials throughout branched geometries of neurons for their survival and function. Many neurodegenerative diseases have been associated with the disruption of transport. Therefore, it is essential to study how neurons control the transport process to localize materials to necessary locations. Here, we develop a novel optimization model to simulate the traffic regulation mechanism of material transport in three-dimensional complex geometries of neurons. The transport is controlled to avoid traffic jams of materials by minimizing a predefined objective function. The optimization subjects to a set of partial differential equation (PDE) constraints that describe the material transport process based on a macroscopic molecular-motor-assisted transport model of intracellular particles. The proposed PDE-constrained optimization model is solved in complex tree structures by using the isogeometric analysis. Different simulation parameters are used to introduce traffic jams and study how neurons handle the transport issue. Specifically, we successfully model and explain the traffic jam caused by the reduced number of microtubules (MTs) and MT swirls. In summary, our model effectively simulates the material transport process in healthy neurons and also explains the formation of a traffic jam in abnormal neurons. Our results demonstrate that both geometry and MT structure play important roles in achieving an optimal transport process in neurons.
Small bowel obstruction due to Roux-en-Y enterolith 13 years following deceased donor liver transplantation: a case report
Authors: Shamaa Tayseer M , Elsabbagh Ahmed , Yoshida Atsushi , Nagai Shunji , Patton Joe H , Abouljoud Marwan 
Published: March 2022

Abstract
Primary sclerosing cholangitis (PSC) is a progressive, cholestatic liver disease, and liver transplantation (LT) is considered the only therapeutic option for patients with end-stage liver disease secondary to PSC. Intestinal obstruction in adults after LT surgery is a rare complication with diverse clinical presentations. The most common etiology is intestinal adhesions, but this can also result from other rare causes such as enterolith. We describe the first case report of small bowel obstruction secondary to biliary stone formation in the common limb of Roux-en-Y hepaticojejunostomy 13 years after the deceased donor LT. The patient failed initial conservative management and developed peritonitis, requiring urgent surgical exploration to remove the enterolith and resect the involved small bowel. In conclusion, small bowel obstructions due to enteroliths are unusual clinical complications following LT, which require a high degree of suspicion in patients who develop a bowel obstruction in the setting of a previous hepaticojejunostomy.
Humeral metastases: an unusual presentation of pancreatic cancer
Authors: McCafferty Jonathan A , Free Matthew D , De Villiers Daniel J , Keith Prue P A 
Published: March 2022

Abstract
In patients presenting with symptomatic bone metastases, the usual primary malignancies are breast, prostate, thyroid, lung and kidney. Pancreatic cancers are an uncommon cause of bone metastasis and, when they are, it is typically to the axial skeleton. We present the case of a 77-year-old woman who presented to our emergency department with right arm pain. Investigation demonstrated a metastatic lesion with impending pathological fracture. Further investigation found a necrotic pancreatic mass in the tail of the pancreas. Histopathology from the humeral metastasis was consistent with metastatic adenosquamous carcinoma of pancreatic origin. The humerus metastasis was successfully managed with an intramedullary nail. This case highlights an unusual presentation of pancreatic adenocarcinoma with humeral bone metastasis.
Gravity-driven filamentary flow in molecular clouds
Authors: Naranjo-Romero Raúl , Vázquez-Semadeni Enrique , Loughnane Robert M 
Published: March 2022

ABSTRACT
We present a numerical study of the gravity-driven filamentary flow arising in the presence of elongated perturbations embedded in a globally gravitationally unstable medium. We perform idealized simulations of the gravitational collapse of a moderate filamentary perturbation with a central enhancement (a core) embedded in either a uniform or a stratified background. Both simulations maintain the filamentary structure during the collapse, developing a hierarchical accretion flow from the cloud to the filament, and from the filament to the core. Only the stratified simulation produces a flat central density profile of filaments, best matching the observed Plummer-like profiles, supporting suggestions that molecular clouds may be preferentially flattened. The flow changes direction smoothly from the cloud to the filament, with no density divergence nor a shock developing at the filament’s axis during the prestellar evolution. The drainage of material by the filament-to-core accretion slows down the growth of the filament, causing the ratio of the core’s central density to the filament’s axial density to increase in time, and to diverge at the time when a singularity (protostar) forms in the core. We argue that the system should evolve towards a stationary state in which the filament-to-core accretion balances the cloud-to-filament one, and search for it in the simulations, but find no unambiguous evidence. However, we find that, after a period of accelerated increase, the filament’s linear mass density reaches a linear growth rate. The stationary state may be approached during the protostellar stage.
SIRIUS Project – V. Formation of off-centre ionized bubbles associated with Orion Nebula Cluster
Authors: Fujii Michiko S , Hattori Kohei , Wang Long , Hirai Yutaka , Kumamoto Jun , Shimajiri Yoshito , Saitoh Takayuki R 
Published: March 2022

ABSTRACT
Massive stars born in star clusters terminate star cluster formation by ionizing the surrounding gas. This process is considered to be prevalent in young star clusters containing massive stars. The Orion Nebula is an excellent example associated with a forming star cluster including several massive stars (the Orion Nebula Cluster, ONC) and a 2-pc-sized H ii region (ionized bubble) opening towards the observer; however, the other side is still covered with dense molecular gas. Recent astrometric data acquired by the Gaia satellite revealed the stellar kinematics in this region. By comparing these data with star cluster formation simulation results, we demonstrate that massive stars born in the ONC centre were ejected via three-body encounters. Further, orbit analysis indicates that θ2 Ori A, the second massive star in this region, was ejected from the ONC centre towards the observer and is now returning to the cluster centre. Such ejected massive stars can form a hole in the dense molecular cloud and contribute to the formation of the 2-pc bubble. Our results demonstrate that the dynamics of massive stars are essential for the formation of star clusters and H ii regions that are not always centred by massive stars.
The effects of LMC-mass environments on their dwarf satellite galaxies in the FIRE simulations
Authors: Jahn Ethan D , Sales Laura V , Wetzel Andrew , Samuel Jenna , El-Badry Kareem , Boylan-Kolchin Michael , Bullock James S 
Published: March 2022

ABSTRACTCharacterizing the predicted environments of dwarf galaxies like the Large Magellanic Cloud (LMC) is becoming increasingly important as next-generation surveys push sensitivity limits into this low-mass regime at cosmological distances. We study the environmental effects of LMC-mass haloes (M200m ∼ 1011 M⊙) on their populations of satellites (M⋆ ≥ 104 M⊙) using a suite of zoom-in simulations from the Feedback In Realistic Environments (FIRE) project. Our simulations predict significant hot coronas with T ∼ 105 K and Mgas ∼ 109.5 M⊙. We identify signatures of environmental quenching in dwarf satellite galaxies, particularly for satellites with intermediate mass (M⋆ = 106–107 M⊙). The gas content of such objects indicates ram pressure as the likely quenching mechanism, sometimes aided by star formation feedback. Satellites of LMC-mass hosts replicate the stellar mass dependence of the quiescent fraction found in satellites of Milky Way-mass hosts (i.e. that the quiescent fraction increases as stellar mass decreases). Satellites of LMC-mass hosts have a wider variety of quenching times when compared to the strongly bimodal distribution of quenching times of nearby centrals. Finally, we identify significant tidal stellar structures around four of our six LMC analogues, suggesting that stellar streams may be common. These tidal features originated from satellites on close orbits, extend to ∼80 kpc from the central galaxy, and contain ∼106–107 M⊙ of stars.
The completed SDSS-IV extended Baryon Oscillation Spectroscopic Survey: growth rate of structure measurement from cosmic voids
Authors: Aubert Marie , Cousinou Marie-Claude , Escoffier Stéphanie , Hawken Adam J , Nadathur Seshadri , Alam Shadab , Bautista Julian , Burtin Etienne , Chuang Chia-Hsun , de la Macorra Axel , de Mattia Arnaud , Gil-Marín Héctor , Hou Jiamin , Jullo Eric , Kneib Jean-Paul , Neveux Richard , Rossi Graziano , Schneider Donald , Smith Alex , Tamone Amélie , Vargas Magaña Mariana , Zhao Cheng 
Published: March 2022

ABSTRACTWe present a void clustering analysis in configuration-space using the completed Sloan Digital Sky Survey IV (SDSS-IV) extended Baryon Oscillation Spectroscopic Survey (eBOSS) DR16 samples. These samples consist of Luminous Red Galaxies (LRGs) combined with the high-redshift tail of the SDSS-III Baryon Oscillation Spectroscopic Survey (BOSS) DR12 CMASS galaxies (called as LRG+CMASS sample), Emission Line Galaxies (ELGs), and quasars (QSOs). We build void catalogues from the three eBOSS DR16 samples using a ZOBOV-based algorithm, providing 2814 voids, 1801 voids, and 4347 voids in the LRG+CMASS, ELG, and QSO samples, respectively, spanning the redshift range 0.6 &lt; z &lt; 2.2. We measure the redshift space distortions around voids using the anisotropic void-galaxy cross-correlation function and we extract the distortion parameter β. We test the methodology on realistic simulations before applying it to the data, and we investigate all our systematic errors on these mocks. We find βLRG(z = 0.74) = 0.415 ± 0.087, βELG(z = 0.85) = 0.665 ± 0.125 and βQSO(z = 1.48) = 0.313 ± 0.134, for the LRG+CMASS, ELG, and QSO sample, respectively. The quoted errors include systematic and statistical contributions. In order to convert our measurements in terms of the growth rate fσ8, we use consensus values of linear bias from the eBOSS DR16 companion papers, resulting in the following constraints: fσ8(z = 0.74) = 0.50 ± 0.11, fσ8(z = 0.85) = 0.52 ± 0.10, and fσ8(z = 1.48) = 0.30 ± 0.13. Our measurements are consistent with other measurements from eBOSS DR16 using conventional clustering techniques.
Refined modelling of the radio SZ signal: kinematic terms, relativistic temperature corrections, and anisotropies in the radio background
Authors: Lee Elizabeth , Chluba Jens , Holder Gilbert P 
Published: March 2022

ABSTRACT
A significant cosmological radio background will inevitably lead to a radio Sunyaev–Zeldovich (SZ) effect. In the simplest limit, the combined signal from the scattered radio and cosmic microwave background exhibits a null at around ν ≃ 735 MHz. Here, we show that kinematic and relativistic temperature corrections to this radio SZ signal are easily calculable. We treat both the cluster and observer motion, and the scattering of anisotropies in the radio background, highlighting how the spectrum of the radio SZ effect is affected in each case. Although relativistic temperature corrections only enter at the level of a few per cent, our expressions allow high-precision modelling of these terms. By measuring the SZ signal around the radio null, one is in principle able to place constraints on the properties of a cosmological radio background. A combination with standard SZ measurements from large cluster samples could provide a promising avenue towards breaking degeneracies between different contributions. Stacking analyses can reduce the effect of kinematic corrections and dipolar anisotropies in the radio background, thereby providing a way to constrain the redshift dependence of the average radio background. Our qualitative discussion is meant to give an analytic understanding of the various effects and also motivate further studies with the aim to obtain quantitative forecasts of their observability. At this stage, a detection of the corrections seems rather futuristic, but the advent of large SZ and X-ray cluster samples could drastically improve our ability to disentangle various effects.