bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Spiritual distress (00066)” in patients under fertility treatment: Clinical validation study
Authors: Romeiro Joana , Caldeira Sílvia , Lopes Marcos Venicios 
Published: July 2022

AbstractPurposeThis study aimed to clinically validate the NANDA‐I nursing diagnosis of “Spiritual distress (00066)” in people under assisted reproductive technologies, and to determine the sensitivity, specificity, and predictive value of the defining characteristics.MethodsCross‐sectional study that was conducted between September 2019 and June 2020. Recruitment happened by invitation posted in fertility‐related websites. Those who accepted to participate were asked to fill the consent form and the online questionnaire. Statistical analysis was based on Rasch's model. The study was approved by the Ethics Committee.FindingsThe sample comprised 104 Portuguese individuals undergoing assisted reproductive techniques. The “Spiritual distress (00066)” was validated and 22 defining characteristics were confirmed as representative. No item showed differential item functioning. “Perceived suffering” was the most sensitive defining characteristic and had the highest negative predictive value. “Insufficient courage” had the highest positive predictive value, and “Anger toward power greater than self” was the most specific.ConclusionsResults validated the presence of the NANDA‐I nursing diagnosis of “Spiritual distress (00066)” in a sample going through assisted reproductive technologies, improving accuracy of this nursing diagnosis in such population.Implications for nursing practiceThis is a crucial step to raise the level of evidence of such nursing diagnosis and to increase the level of evidence on NANDA‐I terminology. Furthermore, this study has contributed to raising the quality of nurse's critical judgement and clinical reasoning and allow an early spiritual and a more holistic and personalized patient‐centered intervention in the reproductive field.
Validation of the Italian version of the spirituality and spiritual care rating scale (SSCRS‐ita)
Authors: Parozzi Mauro , Terzoni Stefano , Ferrara Paolo , Miseroni Francesco , D'Antuono Agostino , Di Prisco Laura , Mcsherry Wilfred , Destrebecq Anne 
Published: July 2022

AbstractPurposeTo translate and validate the Italian version of the Spirituality and Spiritual Care Rating Scale (SSCRS‐ita).MethodsA single‐center cross‐sectional study was performed from October 15 to November 15, 2019 in a public hospital in Milan, Italy. The scale was drafted using the back‐translation method. Prior to administration, the Italian version of the scale was assessed for content validity and retest stability by calculating the content validity index. Internal consistency was investigated by calculating Cronbach's alpha coefficient, test‐retest stability by Spearman's rho coefficient.FindingsA total n = 337 nurses participated in the survey by correctly completing the scale. The Kaiser–Meyer–Olkin test (0.81) and Bartlett's test of sphericity (p < 0.001) confirmed the adequacy of the sample to conduct exploratory factor analysis (EFA). The factorial model of EFA without rotation and then with nonorthogonal Promax rotation confirmed the presence of the four constructs identified by the original author.ConclusionsSSCRS‐ita showed promising psychometric properties in terms of validity and reliability. The results of this study, together with the lack of in‐depth studies in the Italian health and educational panorama, suggest the need to develop an educational pathway which, starting from the curricula of basic training and continuing with the updating of nursing staff, is dedicated to the detection of the spiritual needs of the patient.Implications for nursing practiceThe SSCRS‐ita is the first validated Italian tool concerning the consideration of the needs of spirituality and spiritual care in healthcare contexts; the possibility to use this tool is the first step towards a better integration of the mentioned dimensions of care in a nursing care qualitative perspective in Italy.
Sex differences in α‐adrenergic receptor function contribute to impaired hypothalamic metaplasticity following chronic intermittent ethanol exposure
Authors: Munier Joseph J. , Marty Vincent N. , Spigelman Igor 
Published: July 2022

AbstractBackgroundIndividuals with alcohol use disorder (AUD) exhibit maladaptive responses of the hypothalamic–pituitary–adrenal (HPA) axis to stress, which has been linked to high rates of relapse to drinking among abstinent individuals. Corticotropin‐releasing factor (CRF) parvocellular neuroendocrine cells (PNCs) within the paraventricular nucleus of the hypothalamus (PVN) are critical to stress‐induced HPA axis activation. Here, we investigate sex differences in synaptic transmission and plasticity in PNCs following the application of the stress‐associated neurotransmitter norepinephrine (NE) in a rat model of AUD.MethodsAdult Sprague–Dawley rats were exposed to 40 days of chronic intermittent ethanol (CIE) vapor and 30 to 108 days of protracted withdrawal. We measured changes in holding current, evoked synaptic currents, and short‐term glutamatergic plasticity (STP) in putative PNCs following the application of NE (10 μM) with and without the selective α1 adrenergic receptor (AR) antagonist prazosin (10 μM) or the α2AR antagonist atipamezole (10 μM). The experiments were performed using whole‐cell patch clamp recordings in slices from CIE rats and air‐exposed controls.ResultsNE application caused two distinct effects: a depolarizing, inward, postsynaptic current and a reduction in amplitude of an evoked glutamatergic excitatory postsynaptic current (eEPSC). Both effects were sex‐ and CIE‐specific. Prazosin blocked the postsynaptic inward current, while atipamezole blocked the NE‐mediated suppression of eEPSCs. Additionally, STP formation was facilitated following NE application only in stress‐naïve males and this response was lost in stressed animals exposed to a 30‐min restraint stress following CIE exposure. Furthermore, NE + prazosin restored STP formation in stressed CIE males.ConclusionsNE exerts excitatory and inhibitory effects on CRF PVN PNCs, and both effects are influenced by sex and CIE. Behavioral and hormonal responses to stress are influenced by STP formation within the PVN, which is lost following CIE and restored with the preapplication of prazosin. The selective blockade of α1AR may, therefore, ameliorate CIE‐induced deficits in HPA responses to stress in a sex‐specific manner.
Diffusion of integrated reporting, insights and potential avenues for future research
Authors: Hossain Amir , Bose Sudipta , Shamsuddin Abul 
Published: July 2022

AbstractThis study reviews the diffusion of integrated reporting (IR) research. The systematic literature review method is used to review the effects of IR at the organisational level, determinants of IR adoption and integrated report quality (IRQ), assurance on IR, economic consequences of IR/IRQ, and research design issues to set agendas for future research. The review covers 119 peer‐reviewed IR articles published in 36 journals between 2012 and 2021. It finds that the IR literature is dominated by organisational‐level studies, but there is limited research on the economic consequences of IR/IRQ, and the findings are inconclusive to date. Further, the factors that determine IR adoption/IRQ are not conclusive, and there is scarce research on IR assurance. This review contributes to the emerging IR literature and provides valuable insights to the International Integrated Reporting Council (IIRC) in establishing the IR framework as a global reporting norm in practice.
Intra‐seasonal and daily variations in nectar availability affect bee assemblage in a monodominant afforested Brazilian Cerrado
Authors: Ballarin Caio S. , Hachuy‐Filho Leandro , Doria Maria Júlia W. , Giffu Murilo M. , Polizello Diego S. , Oliveira Pablo H. , Lacerda‐Barbosa Pedro A. , Amorim Felipe W. 
Published: July 2022

AbstractNectar is the most common floral resource that mediates plant–pollinator interactions, and its spatiotemporal distribution is related to pollinator attraction and can influence pollinator activity through time. Therefore, assessing patterns of floral phenology of nectar‐producing plants can help better understand the pollinator assemblage's temporal dynamics. We used an area of afforested Brazilian Cerrado covered with a high‐density plantation of Inga vera, a mass‐flowering nectar‐producing tree, to investigate whether intra‐seasonal and daily variations in nectar availability provided by I. vera flowers affect the bee assemblage. We showed that bee abundance was positively related to intra‐seasonal patterns in floral phenology and daily changes in nectar production. Although bee species richness was also associated with intra‐seasonal changes in nectar availability, bee diversity (quantified using Simpson's diversity index) did not follow the same pattern. We suggest that the dominance of the invasive honeybee, Apis mellifera, on I. vera flowers may have affected the overall bee diversity over time due to an exacerbated increase in honeybee abundance. Therefore, by evaluating the temporal dynamics of nectar availability, an important floral attribute that influences plant–pollinator interactions, we suggest that planting high‐rewarding tree species at high densities in open ecosystems can affect the dynamics of native bee assemblages negatively due to the exacerbated recruitment of the dominant exotic honeybee.
A General Framework for Subgroup Detection via One-Step Value Difference Estimation
Authors: Johnson Dana , Lu Wenbin , Davidian Marie 
Published: July 2022

Abstract
Recent statistical methodology for precision medicine has focused on either identification of subgroups with enhanced treatment effects or estimating optimal treatment decision rules so that treatment is allocated in a way that maximizes, on average, predefined patient outcomes. Less attention has been given to subgroup testing, which involves evaluation of whether at least a subgroup of the population benefits from an investigative treatment, compared to some control or standard of care. In this work, we propose a general framework for testing for the existence of a subgroup with enhanced treatment effects based on the difference of the estimated value functions under an estimated optimal treatment regime and a fixed regime that assigns everyone to the same treatment. Our proposed test does not require specification of the parametric form of the subgroup and allows heterogeneous treatment effects within the subgroup. The test applies to cases when the outcome of interest is either a time-to-event or a (uncensored) scalar, and is valid at the exceptional law. To demonstrate the empirical performance of the proposed test, we study the type I error and power of the test statistics in simulations and also apply our test to data from a Phase III trial in patients with hematological malignancies.
Peripheral‐blood cytopenia, an early indicator of inborn errors of immunity
Authors: Cornelissen Helena M. , Musekwa Ernest M. , Glashoff Richard H. , Esser Monika , Zunza Moleen , Abraham Deepthi R. , Chapanduka Zivanai C. 
Published: July 2022

SummaryInborn errors of immunity (IEI) are inherited monogenic disorders resulting in defective immune response. Non‐infectious presentations are increasingly more apparent. Widely available, cost‐effective early indicators are needed. Peripheral‐blood cytopenia may be a presenting laboratory feature or an observed secondary phenomenon. This retrospective review of the South African Primary Immunodeficiency Registry (SAPIDR) aimed to assess the haematological indices at presentation and their association with the International Union of Immunological Societies (IUIS) 2019 IEI classification and mortality. Of 396 patients on the SAPIDR, 66% (n = 257) had available haematological results. Sixty percent were males and 85% under 18 years. A majority (53%) had predominantly antibody deficiency. At presentation, infection was prominent (86%) followed by cytopenia (62%). Neutropenia was associated with IUIS III [odds ratio (OR) 3.65, confidence interval (CI) 1.44–9.25], thrombocytopenia with IUIS II (OR 14.39, CI 2.89–71.57), lymphopenia with IUIS I (OR 12.16, CI 2.75–53.73) and pancytopenia with IUSI I (OR 12.24, CI 3.82–39.05) and IUIS II (OR 5.99, CI 2.80–12.76). Cytopenia showed shorter overall survival (OR 2.81, CI 1.288–4.16). Cytopenias that are severe, persistent, unusual and/or recurrent should prompt further investigation for IEI. The full blood count and leucocyte differential may facilitate earlier identification and serve as an adjunct to definitive molecular classification.
Hydrogen bonding penalty used for virtual screening to discover potent inhibitors for Papain‐Like cysteine proteases of SARS‐CoV‐2
Authors: Zhao Guangjian , Liu Xiaochun , Wang Suyun , Bai Zhongyue , Zhang Siyu , Wang Yifan , Yu Haibo , Xu Ximing 
Published: July 2022

AbstractThe Papain‐Like proteases (PLpro) of SARS‐CoV‐2 play a crucial role in viral replication and the formation of nonstructural proteins. To find available inhibitors, the 3D structure of PLpro of SARS2 was obtained by homologous modelling, and we used this structure as a target to search for inhibitors through molecular docking and MM/GBSA binding free energy rescoring. A novel hydrogen bonding penalty was applied to the screening process, which meanwhile took desolvation into account. Finally, 61 compounds were acquired and 4 of them with IC50 at micromolar level tested in vitro enzyme activity assay, which includes clinical drugs tegaserod. Considering the importance of crystal water molecules, the 4 compounds were re‐docked and considered bound waters in the active site as a part of PLpro. The binding modes of these 4 compounds were further explored with metadynamics simulations. The hits will provide a starting point for future key interactions identified and lead optimization targetting PLpro.
Abutment mechanical complications of a Morse taper connection implant system: A 1‐ to 9‐year retrospective study
Authors: Yang Fan , Ruan Yan , Liu Yunqing , Chen Jianping , Chen Yunfang , Zhang Wentao , Ding Yude , Wang Linhong 
Published: July 2022

AbstractBackgroundThe fracture of a Morse tapered abutment connection in an osseointegrated implant is one of the most serious mechanical complications, and it is extremely hard to deal with this complication in clinical practice.PurposeThe aim of this study was to explore the cumulative mechanical complications focus on abutment of a platform switching Morse taper connection implant system after loading, and to perform a retrospective, approximately 1‐ to 9‐year follow‐up study to identify the predisposing factors.Materials and MethodsA total of 495 patients with 945 fitted implants were enrolled in this study with a follow‐up from January 2012 to January 2020. The data of mechanical complications of the abutment, including abutment fracture (AF) and abutment screw loosening (ASL), and possible causative factors were extracted and evaluated statistically.ResultsA total of 25 out of 945 (2.65%) cumulative abutment mechanical complications occurred. AF was the most common complication (n = 13, 1.38%), followed by ASL (n = 12, 1.27%). For AF, gender, type of prosthesis, abutment design, and implant diameter were identified as the causative factors. AF was mostly observed in the single crown of males in molar areas, while ASL was more likely to occur on an angled abutment than on a non‐angled abutment. Moreover, the abutment with the positioning index (/X) had a higher incidence of fracture than the abutment without the positioning index (C/).ConclusionsThis study shows that the Morse taper connection is a safe abutment connection. AF occurs more frequently within single crowns in molar area of males, especially with the positioning index (/X), while ASL is more likely to occur in an angled abutment.
Anoplasty for anatomical anal stenosis: systematic review of complications and recurrences
Authors: Gallo Gaetano , Picciariello Arcangelo , Di Tanna Gian Luca , Pelizzo Patrizia , Altomare Donato Francesco , Trompetto Mario , Santoro Giulio Aniello , Roviello Franco , Felice Carla , Grossi Ugo 
Published: July 2022

AbstractAimThe optimal surgical treatment for anatomical anal stenosis (AS) remains to be determined. The aim of this study was to determine the rates of complications and recurrence after anoplasty for anatomical AS and, wherever feasible, compare the outcomes for the various techniques.MethodA PROSPERO‐registered systematic review was reported following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Medline, PubMed, Embase, Cochrane Library of Systematic Review, Scopus and Web of Science were searched for articles published up to May 2021. Studies that assessed the outcomes of anoplasty in adult patients with anatomical AS were selected. The primary outcomes were complications and recurrence. The methodological quality of studies was appraised using the Joanna Briggs Institute critical appraisal tools.ResultsFrom the total of 2705 unique screened records, 151 were assessed for eligibility. Only 29 studies (two prospective) met the inclusion criteria, reporting data on 556 patients [mean age 53 (18–83) years, 46% female]. Previous history of surgery for haemorrhoidal disease accounted for three quarters of cases. A total of 14 types of anoplasty were found, with the Y–V flap being the most performed technique [27% of cases (n = 149)]. Complications frequently occurred, with a pooled prevalence of 10.2% (95% CI 3.9%–24.1%) after Y–V flap and 11.5% (5.3%–23.0%) after rhomboid/diamond flap. Patients undergoing house flap achieved better results in terms of clinical improvement, satisfaction and quality of life compared with Y–V flap and rhomboid/diamond flap. When considering only studies with at least 12 months of follow‐up, the pooled prevalence of recurrence was 4.7% (2.2%–9.8%), with significantly higher rates observed in the prospective versus retrospective series [pooled prevalence 18.9% (11.5%–29.5%) vs. 3.6% (1.7–7.8%), respectively; p < 0.001].ConclusionBoth complications and recurrence were significantly lower after house flap compared with rhomboid/diamond and Y–V flap. Better designed multicentre studies with longer follow‐up are needed to confirm these findings.PROSPERO registration numberCRD42021239493.
Ownership, innovation, and variable institutional quality
Authors: Tran Hien Thu , Freel Mark 
Published: July 2022

AbstractResearch question/issueInnovation has been a constant feature of the tales of transition and transformation. State ownership as the engine of innovation and technological change may be juxtaposed with the “liability of stateness” and the notion that “privatization works.” This study seeks to investigate the relationship between legal ownership and innovation inputs and outputs, while accounting for the moderating effect of institutional quality on this relationship.Research findings/insightsWe exploit unique data from a very large‐scale panel survey of enterprises (65,750 firms between 2006 and 2014) in Vietnam, a fast‐growing but understudied transition country, and apply advanced methodologies that control for the endogeneity of institutions. Our findings point to the continued dominance of state‐owned enterprises (SOEs) in innovation activities in Vietnam. However, the returns to innovation in SOEs accrue only up to a point and improving institutional quality serves to diminish their advantage over privately‐owned enterprises (POEs) and to level the playing field.Theoretical/academic implicationsWe employ an integrated framework that develops predictions from resource dependence, agency, and institutional theories to explore the direct and contingent influences of ownership and institutional quality on firm‐level innovation activities. Our study contributes to the growing literature on state ownership and innovation in transition and emerging economies and the recent calls for greater attention to local institutional context and revising the existing theories on “state underperformance.”Practitioner/policy implicationsThis study offers insights to policy makers in enhancing the quality of local institutions. Higher‐quality institutions moderate the advantages state ownership confers and ameliorate the disadvantages associated with private ownership.
Policy and the social burden of bald eagle recovery
Authors: Watts Bryan D. , Byrd Mitchell A. 
Published: July 2022

AbstractOne of the challenges of applying endangered species policy on private property is striking an equitable balance between species protection and civil liberties. The future of many imperiled species depends on a public‐private trust. We estimate the social burden of managing bald eagles on private lands within the lower Chesapeake Bay (1976–2016). We quantify the area of private and government‐owned land deemed critical around nests and estimate the value of private properties as an index of burden. The bald eagle population increased from 30 to 1052 breeding pairs and the land within nest buffers increased from 384 to 10,670 ha with >80% on private lands. Estimated value of private property “under guidelines” increased more than 900 fold. More than 94% of this burden was imposed after eagles reached recovery goals. Restricting activities on private lands to achieve diminishingly small conservation benefits threatens to undermine landowner participation in conservation efforts.
Next‐generation sequencing improves agreement and accuracy in the diagnosis of Spitz and spitzoid melanocytic lesions
Authors: Roth Andrew , Lampley Nathaniel , Boutko Anastasiya , Zhao Jeffrey , Benton Sarah , Olivares Shantel , Zembowicz Artur , Gerami Pedram 
Published: July 2022

AbstractBackgroundSpitzoid melanocytic neoplasms can be challenging to diagnose on histopathology alone. Next‐generation sequencing (NGS) offers promise as a valuable aid in the diagnosis. Recently, one study reported increased inter‐rater agreement in the diagnosis of spitzoid melanocytic neoplasms among 20 expert melanoma pathologists after incorporating NGS data. We hypothesized that NGS would carry a similar utility in a broader group of dermatopathologists and general pathologists.MethodsSixty‐three participants of a live online (www.Dermpedia.org) CME course rendered a diagnosis on 70 cases composed of melanocytic neoplasms with spitzoid features. In Survey 1, cases included H&E slides and demographic information only, while Survey 2 included NGS data.ResultsWith NGS information, inter‐rater agreement significantly improved from “fair” to “almost perfect” and from “fair” to “substantial” for categorizing lesions as Spitz versus non‐Spitz and conventional melanoma versus not, respectively. There was also an increase in diagnostic accuracy, evidenced by improved recognition of three metastatic tumors as being conventional melanomas.ConclusionThe study supports the adoption of NGS as a valuable diagnostic adjunct for both expert and broader dermatopathologists in their assessments of spitzoid neoplasms.