bluuebunny/crossref_metadata_2025_split huggingface dataset:
Covariance’s Loss is Privacy’s Gain: Computationally Efficient, Private and Accurate Synthetic Data
Authors: Boedihardjo March , Strohmer Thomas , Vershynin Roman 
Published: September 2022

AbstractThe protection of private information is of vital importance in data-driven research, business and government. The conflict between privacy and utility has triggered intensive research in the computer science and statistics communities, who have developed a variety of methods for privacy-preserving data release. Among the main concepts that have emerged are anonymity and differential privacy. Today, another solution is gaining traction, synthetic data. However, the road to privacy is paved with NP-hard problems. In this paper, we focus on the NP-hard challenge to develop a synthetic data generation method that is computationally efficient, comes with provable privacy guarantees and rigorously quantifies data utility. We solve a relaxed version of this problem by studying a fundamental, but a first glance completely unrelated, problem in probability concerning the concept of covariance loss. Namely, we find a nearly optimal and constructive answer to the question how much information is lost when we take conditional expectation. Surprisingly, this excursion into theoretical probability produces mathematical techniques that allow us to derive constructive, approximately optimal solutions to difficult applied problems concerning microaggregation, privacy and synthetic data.
What to advise to patients with only one good quality blastocyst, PGT-A or not? Outcomes of 2064 cycles
Authors: Kahraman Semra , Duzguner Ipek Nur Balin , Sahin Yucel , Irez Tulay 
Published: September 2022

Abstract
Purpose
To evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) is beneficial for patients who have only one blastocyst available for biopsy or transfer.

Methods
This retrospective study was based on 1126 single blastocyst PGT-A and 938 non-PGT-A cycles, a total of 2064 ART cycles which resulted in a single good quality blastocyst in women between 20 and 45 years old. The PGT-A group had 225 single euploid embryo transfer cycles and the non-PGT-A group had 938 single blastocyst embryo transfer cycles.

Results
In the generalized linear mixed model (GLMM), female age and PGT-A variables were found to be significant variables on pregnancy outcomes. In the PGT-A cases, regardless of the effect of other variables, the probabilities of clinical pregnancy and live birth were found to be 3.907 and 3.448 fold higher respectively than in the non-PGT-A cases (p < 0.001). In non PGT-A cases, the probability of a total pregnancy loss was found to be 1.943 fold higher (p = 0.013).

Conclusion
PGT-A in the presence of a single blastocyst significantly increases clinical pregnancy and live birth rates and decreases total pregnancy losses regardless of age. In addition, aneuploid embryo transfer cancelations prevent ineffective and potentially risky transfers.
Does early publishing in top journals really predict long-term scientific success in the business field?
Authors: Hou Li , Wu Qiang , Xie Yundong 
Published: September 2022

AbstractThe soaring number of researchers has led to increasingly intense competition in academia. Early identification of scientists’ potential is a practical but difficult issue currently attracting escalating attention. This study takes the business field as an example and explores whether early publishing in top journals is an effective yardstick to recognise scientists who will have better academic performance in their careers. We extract the career records of publication and citations for 1933 business scientists with stable and continuous publication records from the combination of the ORCID and Scopus databases. Through regression analysis and various checks, we find that researchers publishing in top journals early in their careers indeed perform better subsequently compared to peers with similar early career profiles but no top journal publications. Our research sheds light on a new perspective for early identification of potential star scientists, especially in the business field, and justifies encouraging junior researchers to devote themselves to publishing in top-ranked peer-reviewed journals.
From the Coast to the High Mountains: A Remote Sensing Survey of Disturbances and Threats to the Archaeology and Heritage of South Sinai
Authors: Tews Sophie , ten Harkel Letty , Shams Ahmed 
Published: September 2022

AbstractThe archaeology and heritage of South Sinai is rich and varied. Most research to date has focused on the High Mountains, specifically the area around the famous St Catherine’s Monastery, placed on the UNESCO World Heritage List in 2002 (Saint Catherine Area, World Heritage Site 954). Recently, the Sinai Peninsula Research and the Endangered Archaeology in the Middle East and North Africa projects have focused on the landscape surrounding the St Catherine’s Monastery. These projects highlighted the wealth of archaeological and heritage sites spanning the prehistoric to modern periods, including sites that are still in use by local communities today, as well as the environmental and anthropogenic factors that threaten their survival, such as climate change, tourism, and the impact of infrastructure developments. By contrast, the archaeology and heritage of the coastal areas was never surveyed systematically until the research presented in this paper. Remote sensing work by the Maritime Endangered Archaeology project revealed a coastal landscape that is likewise rich in archaeological and heritage sites. As in the High Mountains, many of the coastal sites are under significant threat, but they do not enjoy the same level of recognition and protection. This paper compares the coastal sites to those in the High Mountains, including their disturbances and threats, and demonstrates the need for a locally specific heritage management and protection strategy for different parts of South Sinai.
Ultrasound and magnetic resonance imaging as diagnostic tools for sarcopenia in immune-mediated rheumatic diseases (IMRDs)
Authors: Salaffi Fausto , Carotti Marina , Di Matteo Andrea , Ceccarelli Luca , Farah Sonia , Villota-Eraso Catalina , Di Carlo Marco , Giovagnoni Andrea 
Published: September 2022

AbstractSarcopenia is characterized by loss of muscle mass, altered muscle composition, fat and fibrous tissue infiltration, and abnormal innervation, especially in older individuals with immune-mediated rheumatic diseases (IMRDs). Several techniques for measuring muscle mass, strength, and performance have emerged in recent decades. The portable dynamometer and gait speed represent the most frequently used tools for the evaluation of muscle strength and physical efficiency, respectively. Aside from dual-energy, X-ray, absorptiometry, and bioelectrical impedance analysis, ultrasound (US) and magnetic resonance imaging (MRI) techniques appear to have a potential role in evaluating muscle mass and composition. US and MRI have been shown to accurately identify sarcopenic biomarkers such as inflammation (edema), fatty infiltration (myosteatosis), alterations in muscle fibers, and muscular atrophy in patients with IMRDs. US is a low-cost, easy-to-use, and safe imaging method for assessing muscle mass, quality, architecture, and biomechanical function. This review summarizes the evidence for using US and MRI to assess sarcopenia.
Vrancea intermediate-depth focal mechanism catalog: a useful instrument for local and regional stress field estimation
Authors: Craiu Andreea , Craiu Marius , Mihai Marius , Manea Elena Florinela , Marmureanu Alexandru 
Published: September 2022

AbstractThe Vrancea seismic zone, located in the bend region of the South-Eastern Carpathians, is a unique area with both crustal and intermediate-depth seismic activity and is known as one of the most active seismic area in Europe. Moderate crustal seismicity is recorded all over the Carpathian region, but the far more intense activity occurs in a small subcrustal seismogenic volume beneath the SE‐bend of the Carpathian arc with about 20 × 50 km lateral and 110 km vertical extent (70–180 km depth). A unique slab geometry, likely preserved until the present, causes stress localization due to the slab bending and subsequent stress release resulting in large mantle earthquakes in the region. The main focus of this study is to determine the focal mechanisms for events with a magnitude larger than 2.7, between 2005 and 2020 and evaluate the current stress field along the Vrancea subcrustal region, from the derived fault plane solutions. The main style of faulting for Vrancea subcrustal events presents a predominant reverse one, with two main earthquakes categories: the first one with the nodal planes, oriented NE–SW parallel with the Carpathian Arc and the second one with the nodal planes, oriented NW–SE perpendicular on the Carpathian Arc. The results of stress inversion indicate a dominant thrust faulting style, with an average stress regime index of 2.87. The stress pattern shows similar partitioning with vertical extension in the slab and no preferred orientation in the overlying crust, showing a transition regime from the extensional regime in the Moesian Platform to the compressional regime in the Vrancea subcrustal zone.
Developing algebraic activity through conjecturing about relationships
Authors: Coles Alf , Ahn Aehee 
Published: September 2022

AbstractThis manuscript contributes to research on how algebraic thinking about operations and properties can develop, and relevant forms of curricular activity. The key question asked is: how can students’ early algebraic activity be fostered through focusing on relations involving operations and properties? We adopt Radford’s three aspects of algebraic thinking (indeterminacy, denotation and analyticity), which focus on considering, symbolising and operating on unknown objects. We investigate the work of a class of 11–12 year old students in re-analysing data collected over 20 years ago as part of a project exploring algebraic activity. Our findings point to the proposal that a focus on conjecturing about relationships can be a powerful route into early algebra. On the basis of our analysis we propose an extension to Radford’s third aspect of algebraic thinking (analyticity) to include structuring a mathematical space, e.g., through a set of conjectures.
Analysis of viral integration reveals new insights of oncogenic mechanism in HBV-infected intrahepatic cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma
Authors: Zhao Linghao , Wang Yuyouye , Tian Tao , Rao Xinjie , Dong Wei , Zhang Jinmin , Yang Yuan , Tao Qifei , Peng Fang , Shen Chenhang , Wang Songbo , Liu Hui , Zeng Xi , Zhou Weiping 
Published: September 2022

Abstract
Background
Integration of HBV DNA into the human genome could progressively contribute to hepatocarcinogenesis. Both intrahepatic cholangiocarcinoma (ICC) and combined hepatocellular-cholangiocarcinoma (CHC) are known to be associated with HBV infection. However, the integration of HBV and mechanism of HBV-induced carcinogenesis in ICC and CHC remains unclear.

Methods
41 patients with ICC and 20 patients with CHC were recruited in the study. We conducted HIVID analysis on these 61 samples to identify HBV integration sites in both the tumor tissues and adjacent non-tumor liver tissues. To further explore the effect of HBV integration on gene alteration, we selected paired tumors and adjacent non-tumor liver tissues from 3 ICC and 4 CHC patients for RNA-seq and WGS.

Results
We detected 493 HBV integration sites in ICC patients, of which 417 were from tumor samples and 76 were from non-tumor samples. And 246 HBV integration sites were detected in CHC patients, of which 156 were located in the genome of tumor samples and 90 were in non-tumor samples. Recurrent HBV integration events were detected in ICC including TERT, ZMAT4, MET, ANKFN1, PLXNB2, and in CHC like TERT, ALKBH5. Together with our established data of HBV-infected hepatocellular carcinoma, we found that HBV preferentially integrates into the specific regions which may affect the gene expression and regulation in cells and involved in carcinogenesis. We further performed genomic and transcriptomic sequencing of three ICC and four CHC patients, and found that HBV fragments could integrate near some important oncogene like TERT, causing large-scale genome variations on nearby genomic sequences, and at the same time changing the expression level of the oncogenes.

Conclusion
Comparative analysis demonstrates numerous newly discovered mutational events in ICC and CHC resulting from HBV insertions in the host genome. Our study provides an in-depth biological and clinical insights into HBV-induced ICC and CHC.
Fenestrate bryozoan fauna from the Middle Devonian of the Eifel (western Rhenish Massif, Germany)
Authors: Ernst Andrej 
Published: September 2022

AbstractSeven fenestrate bryozoans are described from the Middle Devonian of the Eifel. Three species were identified asProlixicella bifurcataErnst and Schroeder, 2007,Rectifenestella aculeata(Sandberger and Sandberger, 1856), andSpinofenestella antiqua(Goldfuss, 1826). Four species are described in open nomenclature:Rectifenestellasp. 1 and sp. 2,Ptyloporasp., andSpinofenestellasp. Analysis of the distribution of the fenestrate bryozoans from the Middle Devonian of the Eifel shows their relatively high level of endemism revealing some few connections to the Devonian of Europe and Asia. The studied association shows similarities to the contemporary fauna from Sauerland.
Comparison of Extraction Methods for the Detection of Tick-Borne Encephalitis Virus RNA in Goat Raw Milk and Cream Cheese
Authors: Müller Irene , Althof Nadine , Hoffmann Bernd , Klaus Christine , Schilling-Loeffler Katja , Falkenhagen Alexander , Johne Reimar 
Published: September 2022

AbstractInfection with the tick-borne encephalitis virus (TBEV) can cause meningitis, meningoencephalitis and myelitis in humans. TBEV is an enveloped RNA virus of the family Flaviviridae, which is mostly transmitted via tick bites. However, transmission by consumption of virus-contaminated goat raw milk and goat raw milk products has also been described. Only a few methods have been reported for the detection of TBEV in food so far. Here, we compare different virus extraction methods for goat raw milk and goat raw milk cream cheese and subsequent detection of TBEV-RNA by RT-qPCR. Langat virus (LGTV), a naturally attenuated TBEV strain, was used for artificial contamination experiments. Mengovirus and the human coronavirus 229E were compared to assess their suitability to serve as internal process controls. Out of three tested extraction protocols for raw milk, sample centrifugation followed by direct RNA extraction from the aqueous interphase yielded the best results, with a recovery rate (RR) of 31.8 ± 4.9% for LGTV and a detection limit of 6.7 × 103 LGTV genome copies/ml. Out of two methods for cream cheese, treatment of the samples with TRI Reagent® and chloroform prior to RNA extraction showed the best RR of 4.7 ± 1.6% for LGTV and a detection limit of 9.4 × 104 LGTV genome copies/g. RRs of Mengovirus and LGTV were similar for both methods; therefore, Mengovirus is suggested as internal process control virus. The developed methods may be useful for screening or surveillance studies, as well as in outbreak investigations.
Shifting Baselines: Longitudinal Reductions in EEG Beta Band Power Characterize Resting Brain Activity with Intensive Meditation
Authors: Skwara Alea C. , King Brandon G. , Zanesco Anthony P. , Saron Clifford D. 
Published: September 2022

Abstract
Objectives
A core assumption of meditation training is that cognitive capacities developed during formal practice will transfer to other contexts or activities as expertise develops over time. This implies that meditation training might influence domain-general neurocognitive systems, the spontaneous activity of which should be reflected in the dynamics of the resting brain. Previous research has demonstrated that 3 months of meditation training led to reductions in EEG beta band power during mindfulness of breathing practice. The current study extends these findings to ask whether concomitant shifts in power are observed during 2 min of eyes closed rest, when participants are not explicitly engaged in formal meditation.

Methods
Experienced meditation practitioners were randomly assigned to practice 3 months of focused attention meditation in a residential retreat, or to serve as waitlist controls. The waitlist controls later completed their own 3-month retreat. Permutation-based cluster analysis of 88-channel resting EEG data was used to test for spectral changes in spontaneous brain activity over the course of the retreats.

Results
Longitudinal reductions in EEG power in the beta frequency range were identified and replicated across the two independent training periods. Less robust reductions were also observed in the high alpha frequency range, and in individual peak alpha frequency. These changes closely mirror those previously observed during formal mindfulness of breathing meditation practice.

Conclusions
These findings suggest that the neurocognitive effects of meditation training can extend beyond the bounds of formal practice, influencing the spontaneous activity of the resting brain. Rather than serving as an invariant baseline, resting states might carry meaningful training-related effects, blurring the line between state and trait change.
Unleashing the Potential of the TQM and Industry 4.0 to Achieve Sustainability Performance in the Context of a Developing Country
Authors: Saha Palash , Talapatra Subrata , Belal H. M. , Jackson Victoria 
Published: September 2022

AbstractBusiness organizations may be able to improve their Sustainability Performance (SP) by adopting Total Quality Management (TQM) concepts combined with Industry 4.0 (I4.0) technologies. This research has developed a model to investigate the influence of TQM and I4.0 on SP. It also analyzes the mediating role of TQM in the relationship between I4.0 and SP. A survey was conducted among 240 respondents employed in ready-made garment (RMG) industries in Bangladesh. A Structural Equation Modelling (SEM) technique was used to analyze the collected data. Research findings show that both TQM and I4.0 technologies have a significant impact on the sustainable growth of the Bangladeshi RMG sector. Moreover, it is observed that TQM mediates the relationship between I4.0 and SP. The findings show that TQM helps to explain the relationship between I4.0 and sustainable performance. This study will provide a guideline for industrial executives on securing sustainability through the adoption of TQM concepts and I4.0 technologies. We are not aware of any additional studies that look at the possible link between TQM, I4.0, and SP, as well as the mediating role of TQM between I4.0 and SP.
One year of COVID-19 pandemic on patients with eating disorders, healthy sisters, and community women: evidence of psychological vulnerabilities
Authors: Meneguzzo Paolo , Sala Alessandra , Merlino Laura , Ceccato Enrico , Santonastaso Paolo 
Published: September 2022

Abstract
Purpose
The COVID-19 pandemic has been a psychological burden worldwide, especially for individuals with eating disorders (EDs). In addition, the healthy sisters of patients with EDs are known to present specific psychological vulnerabilities. This study evaluates differences between the general population, patients with EDs, and their healthy sisters.

Method
A group of 233 participants (91 patients with EDs, 57 of their healthy sisters and 85 community women) was enrolled in an online survey on general and specific psychopathology 1 year after the beginning of the COVID-19 pandemic. The survey examined associations between posttraumatic symptoms and depression, anxiety, obsessive–compulsiveness, interpersonal sensitivity, and eating-related concerns.

Results
Clinically relevant scores for posttraumatic disorders were found in patients with EDs. Healthy sisters scored similarly to patients for avoidance. Regression analysis showed specific associations between interpersonal sensitivity and posttraumatic symptomatology in patients and healthy sisters, but not in community women.

Conclusion
The psychological burden in patients with EDs is clinically relevant and linked to interpersonal sensitivity, obsessive–compulsiveness, and global symptom severity. Differences between patients, healthy sisters, and community women are discussed regarding vulnerability factors for EDs.

Level of evidence
Level III: evidence obtained from well-designed cohort or case–control analytic studies.
A Markov jump process associated with the matrix-exponential distribution
Authors: Peralta Oscar 
Published: September 2022

AbstractLet f be the density function associated to a matrix-exponential distribution of parameters
$(\boldsymbol{\alpha}, T,\boldsymbol{{s}})$
. By exponentially tilting f, we find a probabilistic interpretation which generalizes the one associated to phase-type distributions. More specifically, we show that for any sufficiently large
$\lambda\ge 0$
, the function
$x\mapsto \left(\int_0^\infty e^{-\lambda s}f(s)\textrm{d} s\right)^{-1}e^{-\lambda x}f(x)$
can be described in terms of a finite-state Markov jump process whose generator is tied to T. Finally, we show how to revert the exponential tilting in order to assign a probabilistic interpretation to f itself.
Returns to public investments in clean plant centers: A case study of leafroll virus-tested grapevines in support of cost-effective grape production systems
Authors: Li Jie , Troendle Jason , Gómez Miguel I. , Ifft Jennifer , Golino Deborah , Fuchs Marc 
Published: September 2022

AbstractViruses and related graft-transmissible pathogens cause diseases that cost the grape industry billions of dollars annually if left uncontrolled. The National Clean Plant Network (NCPN), a USDA Farm Bill program, is an organization of clean plant centers that produce and maintain virus-tested foundation vine stocks and distribute propagation material derived thereof to nurseries and growers to minimize the introduction of viruses and virus-like diseases into the vineyard. Foundation Plant Services (FPS) is the major NCPN-grapes center. We examined the economic impacts of public investments in FPS from 2006 to 2019. By focusing on grapevine leafroll disease, our analyses revealed a benefit-cost ratio ranging from 22:1 to 96:1, with a 5% and a 20% disease infection rates in commercial vineyards, respectively. A welfare analysis was consistent with grape growers and nurseries capturing most (64–98%) of the benefits from adopting clean planting material compared with winemakers and other actors in the downstream wine supply chain system. This study provided new insights into the returns to public investments in a clean plant center and documented strong financial incentives for higher adoption of clean vines derived from virus-tested stocks, while justifying continued support of NCPN centers from public and private sectors.