bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Soybean Resistance Level to Pod Sucking Bug Riptortus linearis F. (Hemiptera: Coreidae) based on No-choice and Free-choice Tests
Authors: Krisnawati A. , Noerwijati K. , Indiati S.W. , . Trustinah , Yusnawan E. , Adie M.M. 
Published: January 2022

Background: The infestation of the pod sucking bug Riptortus linearis is one of the limiting factors of soybean productivity in Indonesia. The research aims were to identify the level of resistance to the pod sucking bug R. linearis on several soybean genotypes based on the no-choice test (NCT) and free-choice tests (FCT). Methods: The genetic materials used were 49 soybean genotypes. The study was conducted in the Indonesian Legumes and Tuber Crops Research Institute (ILETRI) from August to December 2020, using the randomized block design in triplicates. The evaluation for pod sucking bug resistance was based on NCT and FCT. Result: The FCT resulted in two genotypes with a consistent moderately resistance level (20-40% of damage intensity) to pod sucking bug based on the pod and seed damage intensity. The NCT method resulted in five genotypes as moderately resistant (20-40% of damage intensity) to pod sucking bug based on the seed damage. The NCT resulted in higher average intensity of pod and seed damage (80.25% and 71.23%, respectively) than the FCT (69.91% and 69.09%, respectively). Two soybean genotypes (Degra/Anjasmoro-1-559 and Anjasmoro/IAC100-2-618) with a consistent moderately resistance level could be used for cultivar improvement in the breeding program. The pod trichome density was suggested to be one of the effective morphological defenses against the pod sucking bug attack.
The Effect of Arrive Angle of External Magnetic Field on The Shape of Hysteresis Curve Permalloy Ni80Fe20 By Simulation
Authors: Lestari Merinda , Nursiyanto Widia , Nugroho Agung Tjahjo 
Published: January 2022

Magnetic sensor is a type of sensor that utilizes changes in resistance caused by changes in the magnetic field H or B. One of the suitable magnetic materials to be used as a study material for making magnetic sensors is permalloy Ni80Fe20. The reading error of the magnetic sensor of the Ni80Fe20 permalloy material affects hysteresis curve of the material and requires correction of the angle of incidence of the external magnetic field in order to provide accurate results on the storage media. In this our current research using Finite Difference OOMMF, we investigated the effect of the angle of incidence of the external magnetic field (H) on the hysteresis curve was carried out on an application based on. The research was conducted by reviewing the parameter literature of the Ni80Fe20 permalloy material and then compiling it in a script and simulating it on an application based on Finite Difference OOMMF. The data obtained from the simulation are normalized magnetization (m), external magnetic field H and coercivity field (Hc) which have been influenced by the angle of incidence. The results of the hysteresis curve at a size of 5 nm with a variation of the angle of incidence 0o are indicated by the value of the external magnetic field H of 10000 mT to -10000 mT with a coercive field Hc of 5000 mT to -5000 mT. The normalized magnetization value m is 1 to -1. The variation of the angle of incidence of 30o produces a coercive field Hc of -108.3 mT to 108.3 mT and a normalized magnetization of 0.86 to -0.86. The 45o incident angle variation produces a coercive field Hc -88.4 mT to 88.4 mT and a normalized magnetization of -0.7 to 0.7
Quantum-electrodynamic magnetic reconnection as the origin of the FRB 200428-associated X-ray burst from SGR J1935+2154
Authors: Xie Y. , Geng Jin-Jun , Zhao Z. H. , Lei Z. , Yuan W. Q. , zhao gang , Wu Xue-Feng , Qiao B. 
Published: January 2022

Abstract
Magnetars, often under the name soft gamma-ray repeaters (SGRs) or anomalous X-ray pulsars, are highly magnetized neutron stars that exhibit diverse X-ray activities. Recently, a unique non-thermal X-ray burst with cut-off energy up to 84 keV is detected and thought to be associated with the fast radio burst (FRB) 200428 in the same single explosive event from SGR J1935+2154, as their spectra show similar feature of narrow double peaks that are emitted almost simultaneously. However, the physical origin of this FRB 200428-associated X-ray burst is still unknown yet. Here, with the first cross-scale numerical simulation in which modeling of particle acceleration by magnetic reconnections is self-consistently coupled with that of photon emission by multiple Compton scatterings, we identify that magnetic reconnection at the quantum-electrodynamic field strength inside the magnetar magnetosphere is the much likely driving source of such FRB-associated non-thermal X-ray burst. Both its temporal and spectral features are well reproduced in our simulations by assuming the plasma magnetization parameter σ~102-103 in consistency with the astronomical observations. The results could greatly promote our understandings of various X-ray burst events from magnetars.
Molecular Dynamics Free Energy Simulation study to Investigate Binding Pattern of Isoliquiritigenin as PPAR𝛾 Agonist
Authors: Singh Amit , Mishra Abha 
Published: January 2022

Abstract
Phytochemicals are rich source of bioactive constituents and can be used as another alternative to currently used drugs for diseases like Diabetes mellitus. The potential of Isoliquiritigenin (a constituent of Pterocarpus marsupium) as PPAR𝛾 agonist was evaluated by in silico technique. Autodock results showed that Tyr327, and Tyr473 of the PPARγ forms H-bonds with Isoliquiritigenin (binding energy of -7.46 kcal/mol) and Troglitazone (known drug) showed H bond with Tyr327, Ser289, with binding energy of -11.01 kcal/mol. Isoliquiritigenin, binding energy in Extra precision (XP) was -6.74 kcal/mol while Troglitazone docking, gave binding energy in XP mode as -9.59 kcal/mol. The best Induced fit docking (IFD) score of the optimised PPARγ- Isoliquiritigenin complexes was -9.39 Kcal/mol. The important residues in IFD forming H bond were Cys 285, Arg 288, Tyr 327 and Leu 340. The post docking MM/GBSA free energy for PPARγ with Isoliquiritigenin and Troglitazone was -49.29 and -71.48 Kcal/mol respectively. Binding interaction in MD simulation and Principal Component Analysis studies revealed stable binding throughout 100 ns simulation. Post Simulation MM/PBSA free energy was calculated. The results indicated that compound possessed a negative binding free energy with -114.37KJ/mol. It was observed that van der Waals, electrostatic interactions and non-polar solvation energy negatively contributed to the total interaction energy while only polar solvation energy positively contributed to total free binding energy. The Isoliquiritigenin fulfils the criteria of drug-likeness property. Thus, study presents a systematic analysis on molecular mechanism of action of Isoliquiritigenin as PPARγ agonist in controlling Diabetes mellitus.
Can Anthropization Govern the Variation in Water Table Levels, Water Flow and Carbon Losses? A Case Study in Tropical Mountain Peatlands an Serra Do Espinhaço Meridional, Minas Gerais, Brazil.
Authors: Barral Uidemar Morais , Silva Alexandre Christófaro , Christófaro Cristiano , Costa Camila Rodrigues , Filho Aparecido Penafort , Macedo Geisla Mendes , Bispo Diêgo Faustolo Alves , Gonçalves Thamires Sabrina 
Published: January 2022

Abstract
Peatlands are ecosystems formed by organic matter (~ 15% of the total mass) and water (~ 85% of the total mass), and constitute a particular type of free aquifer. They perform important hydrological functions by storing excess water during rainfall events, contributing to the baseflow of its rivers throughout the year. Degradation affects the dynamics of the water table, which, in turn, can influence the decomposition of organic matter content and the release of carbon into its waters. Its water retention capacity may also be compromised and reduce the volume of water available downstream, especially in the dry season. The aim of this study was to evaluate the effects of anthropic interference on variations in groundwater, water storage, and carbon flow in two tropical mountain peatlands, located at the head of the Araçuaí River, in Serra do Espinhaço Meridional (SdEM), Minas Gerais, Brazil. Groundwater levels were installed in piezometers distributed on a peatland located in a protected area (Natural Park) (Protected - TP) and in a peatland located outside the conservation unit (Anthropized - TA). Data were analyzed considering the daily rainfall recorded by an automatic weather station installed in the study area. From the data on precipitation and water table level variation, the specific yield (Sy) in the two peatlands was calculated. The observed flows and the mean monthly Sy on each piezometer were correlated and their significance was verified using the t test (p <0.05). The relationship between the observed flow and the mean monthly values of Sy obtained for the piezometers were verified through multiple regression. The specific yield correlated significantly with flow in both peatlands (p < 0.05). Multiple linear regression showed a coefficient of determination (R2) of 0.92 in both peatlands, indicating a direct relationship between Sy and observed flow. The TP presented a 43% smaller variation in the water table, a 7% higher specific yield and a specific flow rate of 13% higher in relation to the TA. The peatland located in a protected area retains more water, with less variation in flow throughout the year, and has less carbon output in the water compared to the anthropized peatland. The results demonstrated that anthropization is causing degradation of the peatland, reducing its water holding capacity and accelerating its carbon losses. In the medium term, these effects may lead to a drastic reduction in flow in the upper course of the Araçuaí River.
New Optical Solitons And Modulation Instability Analysis of Generalized Coupled Nonlinear Schrodinger-KdV System
Authors: Mathanaranjan Thilagarajah 
Published: January 2022

Abstract
In this study, the generalized coupled nonlinear Schrodinger-KdV (NLS-KdV) system is investigated to obtain new optical soliton solutions. This system appears as a model for reciprocity between long and short waves in various of physical settings. Different kind of new soliton solutions including dark, bright, combined dark-bright, singular and combined singular soliton solutions are obtained using two effective methods namely, the extended sinh-Gordon equation expansion method and the solitary wave ansatz method. In addition, the modulation instability analysis of the system is presented based on the standard linearstability analysis. The behaviours of obtained solutions are expressed by 3D graphs.
Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission To Participate In Fentanyl-Induced Hyperalgesia In Rats
Authors: Bai Tianyu , Chen Hengling , Hu Wenwu , Liu Jingtao , Lin Xianguang , Chen Su , Luo Fang , Yang Xiaofei , Chen Jun , Li Chenhong 
Published: January 2022

Abstract
The underlying mechanisms of opioid-induced hyperalgesia (OIH) remain unclear. Herein, we found that the protein expression of metabotropic glutamate receptor 1 (mGluR1) was significantly increased in the right, but not in the left laterocapsular division of central nucleus of the amygdala (CeLC) in OIH rats. In CeLC neurons, the frequency and the amplitude of mini-excitatory postsynaptic currents (mEPSCs) were significantly increased in fentanyl group which were decreased by acute application of a mGluR1 antagonist, A841720. Finally, the behavioral hypersensitivity could be reversed by A841720 microinjection into the right CeLC. These results show that the right CeLC mGluR1 is an important factor associated with OIH that enhances synaptic transmission and could be a potential drug target to alleviate fentanyl-induced hyperalgesia.
The Optimized Inclusion Level of Bacillus Subtilis Fermented Azolla Pinnata In Nile Tilapia (Oreochromis Niloticus) Diets: Immunity, Antioxidative Status, Intestinal Digestive Enzymes and Histomorphometry, And Disease Resistance
Authors: Ismail Taha , Hegazi Elsayed , Nassef Eldsokey , Habotta Ola A. , Gewaily Mahmoud S. 
Published: January 2022

Abstract
A 95-day feeding trial was conducted to evaluate the outcomes of feeding Bacillus subtilis fermented Azolla (BSFA) on nonspecific immunity, antioxidative status, intestinal digestive enzymes and histomorphometry, and disease resistance in the Nile tilapia. We formulated five isonitrogenous and isocaloric experimental diets to incorporate BSFA at (0%, 15%, 30%, 45%, 60%). The growth performance parameters (FBW, BWG, SGR, PER and FCR) revealed a significant increase in the BSFA30 tilapia group compared to the control group followed by BSFA45 (P < 0.05). The BSFA30 group exhibited the highest nonspecific immunity parameters (lysozyme activity, phagocytic index and phagocytic activity) compared to other groups (P < 0.05). SOD and GPx reported the highest values in the BSFA60 group. Nile tilapia carcass composition was not influenced by BSFA inclusion level (P ˃ 0.05). Interestingly, Nile tilapia fed with BSFA15 diet exhibited the highest protease activity level (P ˂ 0.05), while those fed on BSFA30 documented the highest amylase activity. Intestinal histomorphology was significantly enhanced with the gradual increase of administrated BSFA. Tilapia disease resistance against A. septicemia, BSFA significantly diminished the cumulative mortality compared to the control group. To sum up, BSFA was more effective in improving the growth performance and immunity of Nile tilapia.
NeuroSAFE PROOF: study protocol for a single-blinded, IDEAL stage 3, multi-centre, randomised controlled trial of NeuroSAFE robotic-assisted radical prostatectomy versus standard robotic-assisted radical prostatectomy in men with localized prostate cancer.
Authors: Dinneen Eoin , Grierson Jack , Magana Ricardo Almeida , Clow Rosie , Haider Aiman , Allen Clare , Heffernan-Ho Daniel , Freeman Alex , Briggs Tim , Nathan Senthil , Mallett Susan , Brew-Graves Chris , Muirhead Nicola , Williams Norman , Pizzo Elena , Persad Raj , Aning Jonathan , Johnson Lyndsey , Oxley Jon , Oakley Neil , Morgan Susan , Tahir Fawzia , Ahmad Imran , Dutto Lorenzo , Salmond Jonathan , Kelkar Anand , Kelly John , Shaw Greg 
Published: January 2022

Abstract
BackgroundRobotic radical prostatectomy (RARP) is a first-line curative treatment option for localized prostate cancer. Postoperative erectile dysfunction and urinary incontinence are common associated adverse side effects that can negatively impact patients’ quality of life. Preserving the lateral neurovascular bundles (NS) during RARP improves functional outcomes. However, selecting men for NS may be difficult when there is concern about incurring in positive surgical margin (PSM) which in turn risks adverse oncological outcomes. The NeuroSAFE technique (intra-operative frozen section examination of the neurovascular structure adjacent prostate margin) can provide real-time pathological consult to promote optimal NS while avoiding PSM.MethodsNeuroSAFE PROOF is a single-blinded, multi-centre, randomised controlled trial (RCT) in which men are randomly allocated 1:1 to either NeuroSAFE RARP or standard RARP. Men electing for RARP as primary treatment, who are continent and have good baseline erectile function (EF), defined by International Index of Erectile Function (IIEF-5) score>21, are eligible. NS in the intervention arm is guided by the NeuroSAFE technique. NS in the standard arm is based on standard of care, i.e., a pre-operative image-based planning meeting, patient-specific clinical information, and digital rectal examination. The primary outcome is assessment of EF at 12-months. The primary endpoint is the proportion of men who achieve IIEF-5 score ≥ 21. A sample size of 404 was calculated to give a power of 90% to detect a difference of 14% between groups based on a feasibility study. Oncological outcomes are continuously monitored by an independent Data Monitoring Committee. Key secondary outcomes include urinary continence at 3 months assessed by the international consultation on incontinence questionnaire, rate of biochemical recurrence, EF recovery at 24-months, and difference in quality of life.DiscussionThe NeuroSAFE PROOF is the first RCT of intra-operative frozen section in radical prostatectomy in the world. It is properly powered to evaluate a difference in the recovery of EF for men undergoing RARP assessed by patient reported outcome measures. It will provide evidence to guide the use of the NeuroSAFE technique around the world.Trial registration: NCT03317990 (23 October 2017). Regional Ethics Committee; reference 17/LO/1978.
Circulating Lymphocyte Subsets are Prognostic Factors in Patients with Nasopharyngeal Carcinoma
Authors: Zhu Jing , Fang Ruhua , Pan Zhiwen , Qian Xu 
Published: January 2022

Abstract
Background: Nasopharyngeal carcinoma (NPC) is a geographically and racially variable disease which has a high incidence in Southeast China. According to previous studies on tumor immunity, we compared multiple clinical parameters and blood indexes to find its relationship with prognosis in NPC patients.Methods: According to the load of EBV at diagnosis, 220 NPC patients receiving concurrent chemoradiotherapy (CRT) were divided into two groups. We compared clinical parameters, peripheral blood mononuclear cells, lymphocyte subsets and biochemical indexes between them. We analyzed distant metastases and overall survival rate between them.Results: In most cases, the two groups showed the same trend. Most blood indexes were decreased during CRT, the decrease in absolute count was more significant than in percentage. The younger age showed the higher CD3+ and CD3+CD8+ percentage. Patients whose EBV DNA≥1500 copies/mL at first diagnosis showed higher pN grade. Among them, higher CD3+CD8+ percentage or lower CD3-CD56+ percentage had batter OS rates. Patients whose EBV DNA<1500 copies/mL at first diagnosis had higher survival rate and longer survival time.Conclusions: CRT cause overall decrease of blood cells in NPC patients. The initial EBV load was related to prognosis. Among all the blood indexes, CD3+CD8+ percentage showed correlation with age and OS rates in patients whose EBV DNA≥1500 copies/mL at first diagnosis, which is worthy of further study.
Clinical Features of Plastic Bronchitis Related to Respiratory Tract Infection in 269 Children
Authors: cui xiaojian , Guo Wei , Zhao Lihua , Zhang Tongqiang , Zheng Jiafeng , Zhao Linsheng , Xu Yongsheng , Zhan Jianghua 
Published: January 2022

Abstract
Background. Plastic bronchitis (PB) is a pulmonary disease characterized by the formation of bronchial casts (BCs) that lead to airway blockage. The study aimed to investigate the clinical features of PB related to respiratory tract infection. Methods. A retrospective analysis was performed on data collected over a 5-year period (from January 2015 to December 2019) on children with PB (n=269). The clinical manifestations, laboratory data, imaging findings and management, were investigated. The single fiberoptic bronchoscopy (FOB, n=144) and multiple-treatment groups (n=125) were compared.Results. A total of 269 PB children were included with a mean age of 6.7 ± 2.8 years. The majority of cases (n=241, 89.6%) were diagnosed with Mycoplasma pneumonia (MP) infection. The mean duration of fever and hospitalization was 10.6 ± 3.7 and 9.3 ± 3.2 days, respectively. All patients presented with cough and fever, 62 (23.0%) suffered from hypoxemia, and 144 (53.5%) had extrapulmonary complications. Higher levels of ESR, CRP, PCT, IL-6, LA, LDH, FER and D-dimer were observed. CT findings, including pulmonary consolidation, segmental or lobar atelectasis, pleural effusion and pleural thickening, were observed in 97.4%, 46.5%, 47.9% and 63.2% of cases, respectively. Furthermore, multivariate logistic regression analysis showed that N% >75.5%, LDH >598.5U/L, and D-dimer>1.2mg/L were independent risk factors for multiple therapeutic FOB. Conclusions. MP is a major pathogen responsible for PB in children. Patients with PB are more likely to experience persistent fever and excessive inflammation and have severe radiological findings. FOB is an effective treatment for patients with PB, and children may require multiple FOBs for cast removal. N% >75.5%, LDH >598.5U/L and D-dimer > 1.2mg/L are independent predictors of multiple FOB treatment.
Quantification and Forecasting of Cumulonimbus (Cb) Clouds Direction, Nebulosity and Occurrence With Autoregression Using 2018-2020 Dataset From Yaounde-nsimalen
Authors: Ringnwi Mbucksek Blaise , Augustin DAÏKA , Rodrigue TSEDEPNOU , André Bon Firmin , Natali Kossoumna Libaa 
Published: January 2022

Abstract
This works reports the quantification and forecasting of Cumulonimbus (Cb) clouds direction, nebulosity and occurrence with auto regression using 2018-2020 dataset from Yaoundé –Nsimalen of Cameroon. Data collected for October 2018-2020 consisted of 2232 hourly observations. Codes were written to automatically align, multi-find and replace data points in excel to facilitate treating big datasets. The approach included quantification of direction generating time series from data and determination of model orders using the correlogram. The coefficients of the SARIMA model were determined using Yule-Walker equations in matrix form, the Augmented Dickey Fuller test (ADF) was used to check for stationarity assumption, Portmanteau test to check for white noise in residuals and Shapiro-Wilk test to check normality assumptions. After writing several algorithms to test different models, an Autoregressive Neural Network (ANN) was fitted and used to predict the parameters over window of 2 weeks. Autocorrelation Function (ACF) shows no correlation between residuals, with p ≤ 0.05, fitting the stationarity assumption. Average performance is 80%. A stationary wavelike occurrence of the direction has been observed, with East as the most frequented sector. Forecast of Cb parameters is important in effective air traffic management, creating situational awareness and could serve as reference for future research. The method of decomposition could be made applicable in future research to quantify/forecast cloud directions.
Provable Advantage in Quantum Phase Learning via Quantum Kernel Alphatron
Authors: Yusen Wu , Wu Bujiao , Wang Jingbo , Yuan Xiao 
Published: January 2022

Abstract
The use of quantum computation to speed-up machine learning algorithms is among the most exciting prospective applications in the NISQ era. Here, we focus on the quantum phase learning problem, which is crucially important in understanding many-particle quantum systems. We prove that, under widely believed complexity theory assumptions, quantum phase learning problem cannot be efficiently solved by machine learning algorithms using classical resources and classical data. Whereas using quantum data, we prove the universality of quantum kernel Alphatron in efficiently predicting quantum phases, indicating clear quantum advantages in such learning problems. We numerically benchmark the algorithm for a variety of problems, including recognizing symmetry-protected topological phases and symmetry-broken phases. Our results highlight the capability of quantum machine learning in efficient prediction of quantum phases of many-particle systems.