bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary tract infection and Diabetes Mellitus—Etio-clinical profile and antibiogram
Authors: Jagadeesan Subramani , Tripathi Brijendra K. , Patel Pranav , Muthathal Subramanian 
Published: May 2022

Context:
A complex dysregulation of glucose homeostasis, Diabetes Mellitus (DM) is an iceberg disease with an ever-rising global (8.5%, 2018) and national prevalence (7.3% - ICMR-INDIAB study, 2017) amidst adults. Besides the micro and macrovascular complications, in virtue of diverse mechanisms that downplay the immune system culminating in an array of infections especially UTIs are commoner in routine diabetic clinics. The spectrum of UTI ranges from asymptomatic bacteriuria (ASB) to serious complications such as emphysematous pyelonephritis, renal abscesses that are encountered frequently among Diabetics than the general population. The risk stratification and varying modalities of presentation of UTIs in diabetics in contrast with non-diabetics are being studied.

Methods and Material:
A prospective comparative cross-sectional study was conducted in 250 adult consenting participants with equal diabetics and non-diabetics with culture-proven UTI, at the Department of Internal Medicine in a tertiary care hospital of National Capital Territory (NCT) of India, after fulfilling appropriate criteria. Alongside socio-demographic details and vitals parameters, glycaemic status assessment and relevant investigations were done in either group.

Results:
Mean age of the participants was 52.18 ± 9.06 with age and gender being reasonably distributed in both the groups. Fever (P <0.01), dysuria (P <0.01), urgency (P <0.01) and urinary frequency (P <0.01) found frequently among non-diabetics wherein vomiting (P <0.01) and incontinence (P <0.01) relatively commoner among diabetics. E. coli, Klebsiella sp., were the most common organisms in both groups with Proteus sp., and Pseudomonas sp., higher among diabetics. Severe infection and Pyelonephritis were frequent (AOR 2.64, 95% CI- 2.01-3.27, P <0.05) among diabetics. Antimicrobial sensitivity patterns were not significantly different among both groups.

Conclusions:
Primary care physicians are to be acquinted with the possibility that UTI in diabetics could exhibit relatively lesser symptoms or more severe forms of UTI at presentation and less favorable outcomes. Further validation from a larger cohort of diabetics is warranted in terms of symptomatology, diagnostic approach, and sensitivity patterns.
Assessment of e-aushadhi program (drug inventory e-health initiative in Rajasthan) using benefit evaluation framework
Authors: Mantri Neha , Joshi Nitin K. , Bhardwaj Pankaj , Manda Balwant , Joshi Vibha , Singh Kuldeep , Passi Rakesh 
Published: May 2022

Background:
E-aushadhi is a drug supply chain management initiative of the Rajasthan government. This study is conducted to assess this e-health program as evidence is lacking in this context

Methods:
A mix-method study was conducted. Primary data were recorded from key stakeholders using qualitative interviews. Secondary data were collected from internet-based searches, reports, documents, and available literature. Findings were contextualized into the Benefit-Evaluation framework using six dimensions

Results:
E-aushadhi provides a systematic approach for sourcing, storing, and re-distribution of essential medicine through its three-tier structure. Its user-friendly dashboard entails accurate entries, customizable reports, and easy tracking. It has reduced workload and improved information management with timely drug supply while allowing monitoring with key performance indicators

Conclusions:
E-aushadhi has been successful in improving beneficiary access at public health facilities and may act as a backbone architecture for various digital interventions in the National Digital Health Mission that supports the universal health coverage.
Challenges and Road Map towards Starting a New COVID Hospital
Authors: Duggal Shalini D. , Gupta Shweta , Vats Sumit , Goyal Ashish 
Published: May 2022

Background and Aim:
With advent of the Coronavirus Disease 2019 (covid-19) pandemic, need for a dedicated government hospital was felt. Following directions after a cabinet decision, a dedicated Covid hospital was made functional within a month in Central district of Delhi. This manuscript briefs the journey and challenges experienced during this mission.

Method:
As per decision of the state health ministry, bed allocation was planned along with provision for diagnosis, treatment and prevention of Covid -19. Various trainings were simultaneously conducted, licences were obtained and manpower and material were arranged starting with procurement to service provision and waste management.

Result:
Concerted efforts resulted in initiation of clinical and diagnostic services within one month of initiation of teamwork. Government supported in all the licencing requirements and material management. The hospital became functional during the first wave; and by the start of second wave, 20-bedded fully equipped Intensive Care Unit (ICU) was ready with pressure swing adsorber (PSA) oxygen generator in premises.

Conclusion:
A well-coordinated action in the right direction with administrative support can help in achieving difficult targets. Opening a new hospital amidst lockdown and resource constraints in an emergency situation was a rewarding achievement.
Comparative and clinical evaluation between piezoelectric and conventional rotary techniques for mandibular impacted third molar extraction
Authors: Sharma Amit Kumar , Gupta Akshat , Pabari Hemang P. , Pathak Sanchaynee K. , Odedra Nilesh H. , Beniwal Jyoti , Arora Karandeep Singh 
Published: May 2022

ABSTRACT

Purpose:
The aim of this study was to evaluate and compare the operative and postoperative outcomes of the mandibular impacted third molar removal using piezoelectric technique and conventional rotary bur technique.

Settings:
The study was conducted in the department of oral and maxillofacial surgery between January 1, 2019, and January 1, 2020.

Materials and Methods:
Thirty patients, with an age of 18–40 years, with asymptomatic bilateral impacted mandibular third molars, were selected for the study and randomly surgical extraction was done either using piezoelectric or the conventional rotary bur technique on each site. The intraoperative time taken, postoperative pain, swelling, and trismus were assessed over a follow-up period of 7 days postoperatively.

Results:
Study and control groups were compared using paired t-test. There was statistical significance in reduction of pain and swelling in the study group where the duration of surgery was increased in the study group.

Conclusion:
Even if piezoelectric technique takes more time but can be used safely as another technique to conventional surgical method with surgical bur and handpiece for removal of impacted mandibular third molars.
Review of current vaccine development platform to prevent coronavirus disease
Authors: Arif Khushboo , Malhotra Shitanshu , Mohammad Shadab , Fatima Somi , Farooqui Sana , Saleem Mohammad 
Published: May 2022

ABSTRACT
On January 30, 2020, the World Health Organization (WHO) declared a severe respiratory disorder syndrome which originated in Wuhan city as a global public health emergency, and the pandemic declaration by the WHO was made on March 11, 2020. Persons infected with SARS-CoV-2 are frequently asymptomatic, yet they have high respiratory viral loads, and they are major purveyors of viral spread. These factors have led to the current explosion of COVID-19 hospitalizations and deaths. Vaccines could play an important role by preventing severe diseases and increasing population immunity and reducing the ongoing health crisis. There is wealth of information for the review available since it is a current topic of interest. Initially, Google Scholar was utilized to take an initial sample of what types of articles are available. We searched other databases such as PubMed, EMBASE, and COCHRANE LIBRARY for research articles published up to March 2021, with no language restrictions. We found seven peer-reviewed publications available on the efficacy of SARS-CoV-2 vaccines: AZD1222 (AstraZeneca/University of Oxford), a ChAdOx1-based vaccine with a reported efficacy of 70.4% and two mRNA-based vaccines: BNT162b2 (Pfizer/BioNTech) with a reported efficacy of 95% and mRNA-1273 (Moderna/NIAID) with a reported efficacy of 94.1%. Internet was used as a source because of its limitless networking of resources. Sources used from the internet were written by professionals in their fields and published on reliable sites, in referred publications, or on professional organization sites. The cited references were within the last 2 years.
Study on Quality Markers and Action Mechanisms of Inulae Flos on Anti-Hepatitis Through Network Pharmacology and High-Performance Liquid Chromatography Fingerprints
Authors: Lin Li , Su Lian-Lin , Li Huan-Huan , Mao Chun-Qin , Ji De , Xie Hui , Lu Tu-Lin 
Published: May 2022

Objective:
The objective of the study is to combine network pharmacology with high-performance liquid chromatography (HPLC) to screen for quality markers (Q-markers) of Inulae Flos and predict mechanism on anti-hepatitis.

Materials and Methods:
Active ingredient library of Inulae Flos is structured using databases and the literature. “Compound-target-pathway” network on anti-hepatitis and protein–protein interaction (PPI) network are constructed using network pharmacology. Next, chromatographic fingerprints of Inulae Flos in 7 origins are obtained through HPLC, and chemometric analysis is implemented to identify chemical markers, which is combined with network pharmacology to identify Q-markers and detect content.

Results:
1,6-O, O-Diacetylbritannilactone, Ivangustin, and Inulanolide A are key ingredients of Inulae Flos to interact with 82 potential targets related to anti-hepatitis. Furthermore, signal transducer and activator of transcription 3, tumor necrosis factor, interleukin-6, and transcription factor AP-1 are the core targets in the PPI network. Chromatographic fingerprints of the Inulae Flos define 20 common peaks and identify 8 peaks using reference substances. Through partial least square discriminant analysis, 7 compounds including caffeic acid, chlorogenic acid, and 1,6-O, O-Diacetylbritannilactone were main chemical markers for variability. 1,6-O, O-Diacetylbritannilactone is both a key ingredient and exclusive chemical marker. Therefore, 1,6-O, O-diacetylbritannilactone is a Q-marker of Inulae Flos, and the average content is 1.82 mg/g.

Conclusion:
1,6-O, O-diacetylbritannilactone is determined to be a Q-marker of Inulae Flos.
İNGİLİZCE DERSİ ÖĞRETİM PROGRAMINDA BELİRTİLEN TEMEL DEĞERLER ÇERÇEVESİNDE 5. SINIF İNGİLİZCE DERSİ KİTAPLARININ İNCELENMESİ
Authors: AKBULUT Salih , ÜZÜM Burhan , PESEN Ata 
Published: May 2022

Amaç: Bu çalışmanın temel amacı, İngilizce dersi öğretim programında belirtilen temel değerler (arkadaşlık, adalet, dürüstlük, öz-denetim, sabır, saygı, sevgi, sorumluluk, vatanseverlik ve diğerkamlık) çerçevesinde 5. sınıf İngilizce dersi kitaplarını incelemektir.
Yöntem: Bu araştırmada analiz edilmesi gereken birden fazla alt tabaka veya alt birim (İngilizce Ders kitapları ve İngilizce Öğretim Programı) olduğundan durum çalışması desenlerinden “iç içe geçmiş tek durum deseni” kullanılmıştır. Verilerin toplanması sürecinde öncelikle hangi dokümanların incelenmesi gerektiğine karar verilmesi gerektiği belirtilmektedir. Bu çalışmada doküman olarak 5. sınıf İngilizce Dersi Öğretim Programı, 2020-2021 eğitim-öğretim yılında devlet okullarının 5. sınıf kademesinde okutulmasına karar verilen İngilizce 5 ve Happy English 5 olmak üzere iki farklı kitap belirlenmiştir. Verilerin analizinde, nitel veri analiz sürecinde doküman incelemesine uygun olarak içerik analizi tekniği kullanılmıştır Bu doğrultuda, verilerin analizinde betimsel istatistik yöntemlerinden frekans ve yüzde tablolarına ek olarak sıklık grafiklerinden de yararlanılmıştır.
Bulgular: Yapılan analizler sonucunda, hem Özel Yayın hem de Millî Eğitim Yayını ders kitaplarında değerlerin neredeyse eşit sayıda vurgulandığı ancak bu değerlerin en çok vurgulandığı ünitelerin kitaplara göre farklılaştığı sonucuna ulaşılmıştır. Ancak, Happy English 5 kitabında İngilizce dersi öğretim programında belirtilen adalet, dürüstlük, sabır ve diğerkamlık değerlerine yer verilmediği tespit edilmiştir. İngilizce 5 kitabında ise adalet, sabır ve diğerkamlık değerlerine yer verilmediği dürüstlük değerine sadece 1 kez yer verildiği belirlenmiştir.
Özgünlük: Bu çalışma, İngilizce öğretim programındaki değerlerin ders kitaplarına ne kadar yansıtıldığını varsa ihmal edilen değerlerin neler olduğunu belirlemek ve bu konuda alanyazına katkı sağlamak bakımından özgün bir makaledir. Dolayısıyla, İngilizce dersi için hazırlanacak olan kitaplarda programda öngörülen değerlere daha fazla yer verilmesi konusunda program geliştiricilere yol göstereceği düşünülmektedir.
Holidaycheck Websitesindeki En İyi Otel Sıralamasına Göre Otellerin Karşılaştırılması: Google Trends Örneği
Authors: KIVILCIM Burcu 
Published: May 2022

Amaç: Bu çalışmanın amacı, Holidaycheck web sitesinde yapılan çevrimiçi değerlendirme ve puanlamalar sonucu belirlenen, Türkiye’nin en iyi ilk beş otelinin dünya genelinde tanınırlığını ortaya koymaktır.
Yöntem: Araştırmada içerik analizi yöntemi kullanılarak Holidaycheck web sitesinden veriler alınmış daha sonra bu veriler Google Trends web sitesi üzerinden sorgulanarak karşılaştırmalı analiz edilmiştir.
Bulgular: Analiz sonucunda, Google aramalarına göre, Tui Blue Palm Garden otelin diğer dört otele göre en iyi otel, Tui Magic Life Sarıgerme otelin ise en az sorgulanan otel olduğu görülmüştür. Döneme göre yapılan inceleme sonucunda otellerin yaz sezonu olan 13 Haziran-06 Ekim tarihleri arasında sık sorgulandığı, ülkelere göre bakıldığında ise, en fazla Almanya’da popüler olduğu sonucuna ulaşılmıştır. Sonuçlar ışığında, alanyazına katkısı bakımından örnekleme diğer çevrimiçi değerlendirme sitelerinin de dâhil edilmesi ve daha fazla otelin karşılaştırılmasının yapılması önerilmektedir. Otel işletmelerine ise, stratejik planlar hazırlarken Google Trends ve Holidaycheck gibi web sitelerin kullanıcı yorumları ve değerlendirmelerini göz önünde bulundurmaları önerilmektedir.
Özgünlük: Çalışma, otel işletmelerinin rekabet avantajı ve sürdürülebilir gelişimine katkı sağlaması açısından önemli olup, konuya ilişkin çalışmaya rastlanılamamış olması sebebiyle özgün bir çalışma niteliği taşımaktadır.
Summer trends and drivers of sea surface fCO2 and pH changes observed in the southern Indian Ocean over the last two decades (1998–2019)
Authors: Leseurre Coraline , Lo Monaco Claire , Reverdin Gilles , Metzl Nicolas , Fin Jonathan , Mignon Claude , Benito Léa 
Published: May 2022

Abstract. The decadal changes in the fugacity of CO2 (fCO2) and pH in surface waters are investigated in the southern Indian Ocean
(45–57∘ S) using repeated summer observations, including measurements of fCO2, total alkalinity (AT) and total
carbon (CT) collected over the period 1998–2019 in the frame of the French monitoring programme OISO (Océan Indien Service d'Observation). We used three datasets (underway fCO2, underway AT–CT and station AT–CT) to evaluate the trends of fCO2 and pH and their
drivers, including the accumulation of anthropogenic CO2 (Cant). The study region is separated into six domains based on the
frontal system and biogeochemical characteristics: (i) high-nutrient low-chlorophyll (HNLC) waters in the polar front zone (PFZ) and (ii) north part
and (iii) south part of HNLC waters south of the polar front (PF), as well as the highly productive zones in fertilised waters near (iv) Crozet Island and (v) north and (vi) south of Kerguelen Island. Almost everywhere, we obtained similar trends in
surface fCO2 and pH using the fCO2 or AT–CT datasets. Over the period 1998–2019, we observed an increase in
surface fCO2 and a decrease in pH ranging from +1.0 to +4.0 µatm yr−1 and from −0.0015 to
−0.0043 yr−1, respectively. South of the PF, the fCO2 trend is close to the
atmospheric CO2 rise (+2.0 µatm yr−1), and the decrease in pH is in the range of the mean trend for the global ocean
(around −0.0020 yr−1); these trends are driven by the warming of surface waters (up to +0.04 ∘C yr−1) and the
increase in CT mainly due to the accumulation of Cant (around +0.6 µmol kg−1 yr−1). In the PFZ, our data
show slower fCO2 and pH trends (around +1.3 µatm yr−1 and −0.0013 yr−1, respectively) associated with an
increase in AT (around +0.4 µmol kg−1 yr−1) that limited the impact of a more rapid accumulation of Cant
north of the PF (up to +1.1 µmol kg−1 yr−1). In the fertilised waters near Crozet and Kerguelen islands, fCO2
increased and pH decreased faster than in the other domains, between +2.2 and +4.0 µatm yr−1 and between −0.0023 and
−0.0043 yr−1. The fastest trends of fCO2 and pH are found around Kerguelen Island north and south of the PF. These trends
result from both a significant warming (up to +0.07 ∘C yr−1) and a rapid increase in CT (up to
+1.4 µmol kg−1 yr−1) mainly explained by the uptake of Cant. Our data also show rapid changes in short periods and
a relative stability of both fCO2 and pH in recent years at several locations both north and south of the PF, which leaves many open
questions, notably the tipping point for the saturation state of carbonate minerals that remains highly uncertain. This highlights the need to
maintain observations in the long-term in order to explore how the carbonate system will evolve in this region in the next decades.
HydroSat: geometric quantities of the global water cycle from geodetic satellites
Authors: Tourian Mohammad J. , Elmi Omid , Shafaghi Yasin , Behnia Sajedeh , Saemian Peyman , Schlesinger Ron , Sneeuw Nico 
Published: May 2022

Abstract. Against the backdrop of global change, in terms of both climate and demography, there is a pressing need for monitoring of the global water cycle. The publicly available global database is very limited in its spatial and temporal coverage worldwide. Moreover, the acquisition of in situ data and their delivery to the database have been in decline since the late 1970s, be it for economical or political reasons. Given the insufficient monitoring from in situ gauge networks, and with no outlook for improvement, spaceborne approaches have been under investigation for some years now. Satellite-based Earth observation with its global coverage and homogeneous accuracy has been demonstrated to be a potential alternative to in situ measurements. This paper presents HydroSat as a database containing geometric quantities of the global water cycle from geodetic satellites. HydroSat provides time series and their uncertainty in water level from satellite altimetry, surface water extent from satellite imagery, terrestrial water storage anomaly represented in equivalent water height from satellite gravimetry, lake and reservoir water volume anomaly from a combination of satellite altimetry and imagery, and river discharge from either satellite altimetry or imagery. The spatial and temporal coverage of these datasets varies and depends on the availability of geodetic satellites. These products, which are complementary to existing products, can contribute to our understanding of the global water cycle within the Earth system in several ways. They can be incorporated for hydrological modeling, they can be complementary to current and future spaceborne observations, and they can define indicators of the past and future state of the global freshwater system. HydroSat is publicly available through http://hydrosat.gis.uni-stuttgart.de (last access: 18 May 2022​​​​​​​). Moreover, a snapshot of all the data (taken in April 2021) is available in GFZ Data Services at https://doi.org/10.5880/fidgeo.2021.017 (Tourian et al., 2021).
Review, Reflection and Redirection in a Writing Program
Authors: Woods Claire 
Published: May 2022

With this paper I want to open a discussion about the nature of undergraduate writing programs. In particular as tertiary institutions make claims for relevance and development of graduate qualities in an undergraduate education, we can examine the role and place of writing programs. How should they be framed? What should they offer students? What emphases are important? I describe the development of an undergraduate award in Professional Writing and Communication. I will consider the original design and then the evolution of the award over five years. The theoretical assumptions underpinning the award are described. Revisions have been made to the award as teaching staff have responded to student needs and to perceived changes in workplace and professional environments. By describing the award, I hope by implication to illuminate and thus raise issues that seem central to the role and place of writing awards in the Australian context.
ETHICAL FORMS OF COLLECTIVE BEHAVIOR AS A WAY OF CONFRONTING THE SPIRITUAL AND MORAL PANDEMIC OF HUMAN DEHUMANIZATION
Authors: Хараева Леорена Ахметовна , Джандар Бетти Махмудовна 
Published: May 2022

Рассматривается проблема этических форм коллективного и индивидуального поведения на фоне опасной гуманитарной ситуации, связанной с негативными тенденциями дезинтеграции и обособления, которые имеют место в современном обществе в широком масштабе. Эти тенденции несут в себе угрозу подрыва самих основ стабильности и равновесия в социальных взаимоотношениях людей и общества в целом. Соответственно нашей актуальной и неотложной задачей на данном этапе является развитие тех форм коллективного и индивидуального этического поведения, которые отвечают идее интеграции и единения людей. Авторы показывают, что идея интеграции, неразрывно связанная с такими понятиями, как «культура», «этика, «нравственность», «гуманизм», направлена на развитие и совершенствование людей и общества. В статье затрагиваются различные формы коллективного и индивидуального этического поведения, включая формы ритуального поведения, которые будут способствовать противостоянию разрушительным природным и социальным силам и выживанию гуманного сообщества людей.
The paper deals with the problem of ethical forms of collective and individual behavior against the background of a dangerous humanitarian situation associated with negative trends of disintegration and separation, which take place in modern society on a wide scale. These trends threaten to undermine the very foundations of stability and balance in the social relations of people and society as a whole. Accordingly, our urgent task at this stage is to develop those forms of collective and individual ethical behavior that are consistent with the idea of integration and togetherness of people. The authors show that the idea of integration, inextricably connected with such concepts as "culture", "ethics", "morality", "humanism" is aimed at the development and improvement of people and society. The paper addresses various forms of collective and individual ethical behavior, including forms of ritual behavior that will contribute to opposing destructive natural and social forces and the survival of a humane community of people.