bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outpatient outcomes of patients with femoral nerve neurapraxia after prone lateral lumbar interbody fusion at L4–5
Authors: Morgan Clinton D. , Katsevman Gennadiy A. , Godzik Jakub , Catapano Joshua S. , Hemphill Courtney , Turner Jay D. , Uribe Juan S. 
Published: February 2022

OBJECTIVE
Single-position prone lateral lumbar interbody fusion (LLIF) improves the efficiency of staged minimally invasive lumbar spine surgery. However, laterally approaching the lumbar spine, especially L4–5 with the patient in the prone position, could increase the risk of complications and presents unique challenges, including difficult ergonomics, psoas migration, and management of the nearby lumbar plexus. The authors sought to identify postoperative femoral neurapraxia after single-position prone LLIF at L4–5 to better understand how symptoms evolve over time.

METHODS
This retrospective analysis examined a prospectively maintained database of LLIF patients who were treated by two surgeons (J.S.U. and J.D.T.). Patients who underwent single-position prone LLIF at L4–5 and percutaneous pedicle screw fixation for lumbar stenosis or spondylolisthesis were included if they had at least 6 weeks of follow-up. Outpatient postoperative neurological symptoms were analyzed at 6-week, 3-month, and 6-month follow-up evaluations.

RESULTS
Twenty-nine patients (16 women [55%]; overall mean ± SD age 62 ± 11 years) met the inclusion criteria. Five patients (17%) experienced complications, including 1 (3%) who had a femoral nerve injury with resultant motor weakness. The mean ± SD transpsoas retractor time was 14.6 ± 6.1 minutes, the directional anterior electromyography (EMG) threshold before retractor placement was 20.1 ± 10.2 mA, and the directional posterior EMG threshold was 10.4 ± 9.1 mA. All patients had 6-week clinical follow-up evaluations. Ten patients (34%) reported thigh pain or weakness at their 6-week follow-up appointment, compared with 3/27 (11%) at 3 months and 1/20 (5%) at 6 months. No association was found between directional EMG threshold and neurapraxia, but longer transpsoas retractor time at L4–5 was significantly associated with femoral neurapraxia at 6-week follow-up (p = 0.02). The only case of femoral nerve injury with motor weakness developed in a patient with a retractor time that was nearly twice as long as the mean time (27.0 vs 14.6 minutes); however, this patient fully recovered by the 3-month follow-up evaluation.

CONCLUSIONS
To our knowledge, this is the largest study with the longest follow-up duration to date after single-position prone LLIF at L4–5 with percutaneous pedicle screw fixation. Although 34% of patients reported ipsilateral sensory symptoms in the thigh at the 6-week follow-up evaluation, only 1 patient sustained a nerve injury; this resulted in temporary weakness that resolved by the 3-month follow-up evaluation. Thus, longer transpsoas retractor time at L4–5 during prone LLIF is associated with increased ipsilateral thigh symptoms at 6-week follow-up that may resolve over time.
School-age outcomes in patients with unilateral coronal synostosis: comparison of fronto-orbital advancement and endoscopic strip craniectomy
Authors: Varagur Kaamya , Skolnick Gary B. , Naidoo Sybill D. , Smyth Matthew D. , Patel Kamlesh B. 
Published: February 2022

OBJECTIVE
Outcomes research on unilateral coronal synostosis is mostly limited to the early postoperative period. This study examines facial asymmetry, desire for revision, and patient-reported outcomes at school age in children who received either endoscopic strip craniectomy with helmet therapy or fronto-orbital advancement (open repair).

METHODS
Patients with repaired unilateral coronal synostosis born between 2000 and 2017, with 3D photographs taken when they were between 3.5 and 8 years of age, were eligible for study inclusion. Three pairs of bilateral linear measurements and two angular measurements were taken. Parent- and physician-reported desire for revision and patient-reported outcomes (Patient-Reported Outcomes Measurement Information System cognitive function and Quality of Life in Neurological Disorders stigma scores) were collected from patient charts.

RESULTS
Thirty-five patients qualified, including 25 with open repair and 10 with endoscopic repair. The median patient ages at repair were 3 months and 8 months in the endoscopic and open groups, respectively. The average ages at final 3D photography were 5.8 years and 5.5 years in the endoscopic and open groups, respectively. Digital anthropometry revealed no significant differences in measures of facial asymmetry between the repair groups (p ≥ 0.211). Midface depth (tragion to subnasale) was significantly less symmetric at school age than other linear measures (F(2,102) = 9.14, p < 0.001). Forehead asymmetry was significantly associated with parent- and physician-reported desire for revision (p ≤ 0.006). No significant associations were found between physical asymmetry and patient-reported stigma or cognitive function (p > 0.046, Holm-Bonferroni correction).

CONCLUSIONS
Children who underwent open or endoscopic repair for unilateral coronal synostosis have comparable facial symmetry at school age, but midface depth remains highly asymmetrical in both groups. Forehead asymmetry at school age correlates with parent- and physician-reported desire for revision.
Foetal Limb in Bladder: A rare complication of vesicouterine fistula
Authors: Singh Khwairakpam Amitkumar , Singh Khoirom Tomba , Singh Khoirom Siddhartha 
Published: February 2022

Vesicouterine fistula(VUF) is a rare urogenital fistula and more rarer is the pregnancy in its presence. Even if pregnancy occurs the outcomes appears to be very poor .Most of the cases are related to iatrogenic bladder injury during caesarean section. There is very limited literature on the pregnancy with VUF associated with herniation of foetus or foetal part(s) into the bladder cavity. Here we report a case of pregnancy in a known case of untreated VUF. She presented at 23 weeks of gestation with features of premature rupture of membrane and herniation of foetal left lower limb inside the bladder cavity. Her pregnancy ended up with hysterotomy and removal of non-viable foetus along with fistula repair. So, regardless of the severity of the signs and symptoms associated with VUF clinicians should convince the patients for repair of the fistula especially if future pregnancy is contemplated .
Spontaneous Intracranial Hypotension associated with Posterior Reversible Encephalopathy Syndrome
Authors: Choudhary Subham , Sethi Dr. Kanika sekhri , Nanda Dr. Satyan , Mehndiratta Dr. Manmohan , Handa Dr Rahul 
Published: February 2022

Spontaneous Intracranial Hypotension (SIH) is usually due to cerebrospinal fluid (CSF) leak, resulting in loss of CSF volume. Posterior reversible encephalopathy syndrome (PRES) is the inability of the posterior circulation of the brain to autoregulate in response to significant variation in blood pressure. Altered perfusion with associated blood-brain barrier disruption may lead to vasogenic edema, usually without infarction, commonly in the parieto-occipital regions. Magnetic Resonance Imaging (MRI) of the brain & Spine and cerebral MR venography (MRV) are essential tools for diagnosing clinically suspected SIH and PRES. We present a case of SIH associated with PRES in an 18-year-young gentleman.
DESENVOLVIMENTO DE UMA FERRAMENTA DE PARAMETRIZAÇÃO DE UM PROJETO MECÂNICO/ESTRUTURAL E CUSTO DE UMA CHAMINÉ DE GASES
Authors: Sato Kleber Augusto Rama , Lauriano Rodolfo Rodrigo de Souza , Bovério Maria Aparecida , Ventura Júnior Antônio Carlos Muniz 
Published: February 2022

Com a difusão da parametrização na indústria, ela se tornou uma ferramenta de grande valia, pois, por meio dela, se obtém a redução de custo em relação a engenheiros e técnicos. Esse artigo apresenta um projeto que desenvolve a parametrização e o custo de uma chaminé de gases, com a utilização do software Autodesk Inventor para elaboração da parametrização, desenho e modelagem, e o software Excel, para cálculos, realizados por fórmulas e funções construídas pelos autores, tendo, assim, a elaboração do custo estimado. Observou-se que os setores de engenharia e custo utilizam metodologias de elaboração de projeto e levantamento de custos distintos. Tais fatores internos se definem pelo feeling e o know-how de cada profissional. O tema foi escolhido considerando-se a necessidade de integração entre os setores de custo e engenharia de produtos, com o propósito de reduzir o tempo de trabalho e retrabalho. Os resultados apresentam todas as possibilidades de ambos os softwares. Concluiu-se que no método de trabalho tradicional leva em torno de 4 a 5 dias para o estudo do projeto, levantamento de materiais e de custos. E, após o desenvolvimento dessa ferramenta, esse tempo cai para em torno de 1 a 2 horas, o que é bastante significativo.
O IMPACTO DA COVID-19 NAS ESTRATÉGIAS DE MARKETING DAS EMPRESAS
Authors: Novaes Matheus Henrique da Silva , Lima Gustavo Barbieri 
Published: February 2022

O objetivo central da presente pesquisa é investigar se os impactos sofridos pelos negócios, especificamente das empresas ALPHA, BETA e GAMA, devido à pandemia do Covid-19, resultou em um direcionamento maior para as estratégias de marketing digital, assim como analisar quais foram as principais ferramentas digitais utilizadas. Utilizou-se o método de estudo multi-caso para se analisar as empresas ALPHA, BETA e GAMA no que tange à utilização do marketing digital. Os principais resultados apontam que: (a) as empresas analisadas, durante a pandemia, investiram mais em marketing digital, redes sociais e e-commerce para alavancarem seus negócios, os quais trouxeram resultados positivos para estas empresas; (b) as estratégias de marketing digital têm melhor custo benefício em relação as realizadas pelo marketing tradicional; (c) por meio dos veículos de comunicação na Internet – mídias digitais –, é possível gerar um relacionamento mais próximo e duradouro entre a marca e o seu público-alvo; (d) à medida que a estratégia de marketing passa do tradicional para o digital, muitos clientes e potenciais clientes começaram a participar da promoção das marcas das empresas e a interagir com as marcas por meio das redes sociais (Facebook, Instagram, etc).
MEDIÇÃO DA QUALIDADE DE SERVIÇO PELO MÉTODO SERVQUAL
Authors: Maemura Marcia Mitie Durante , Galli Lesley Carina do Lago Attadia , Garcia Sheila Farias Alves , Prates Glaucia Aparecida , Arroyo Cristiane Sonia 
Published: February 2022

Dado o crescimento e a importância econômica e social dos pesqueiros no Brasil é fundamental que os pesqueiros avaliem o nível da qualidade de serviços aos clientes, pois a qualidade em serviços proporciona vários benefícios para as empresas. Assim, a presente pesquisa tem como objetivo medir o nível da qualidade dos serviços prestados por um pesqueiro localizado na região de Taubaté-SP, utilizando como referência o modelo SERVQUAL, desenvolvido por Parasuraman, Zeithaml e Berry (1985). A escolha deste modelo de mensuração justifica-se pelo fato de ser largamente aplicado em diversos segmentos de serviços, com resultados assertivos e satisfatórios. Para tanto, foi realizada uma pesquisa junto a 600 clientes de um empreendimento do tipo "pesqueiro" na cidade de Taubaté/SP. Após uma análise descritiva das respostas coletadas, foi possível identificar: o perfil do cliente, a avaliação da qualidade em serviços, o nível de satisfação do cliente e as recomendações de melhoria dos clientes. Com os resultados obtidos pode-se afirmar assim que o modelo SEVQUAL, mostrou-se consistente como ferramenta para medição da qualidade de serviços do pesqueiro pesquisado. A metodologia utilizada neste trabalho apresentou resultados consistentes quanto à percepção de clientes sobre os serviços prestados pelo pesqueiro - especialmente, quanto a disponibilização de materiais relacionados à prática da pescaria esportiva, disponibilização de informações de consumo (placas, aspectos relacionados à cobrança de serviços) e conduta dos profissionais atuantes na empresa.
Strategy for Scanning Peptide-Coding Circular RNAs in Colorectal Cancer Based on Bioinformatics Analysis and Experimental Assays
Authors: Chen Zhanghan , Qi Zhipeng , He Dongli , Liu Jingyi , Xu Enpan , Li Bing , Cai Shilun , Sun Di , Cheng Yirong , Shi Qiang , Zhong Yunshi 
Published: February 2022

Background: Colorectal cancer (CRC) is the third most common cause of cancer deaths worldwide. Numerous studies have reported that circular RNAs (circRNAs) have important functions in CRC. It was first thought that circRNAs were non-coding RNA; however, more recently they were discovered to encode peptides and play a pivotal role in cancer development and progression. It was shown that most circRNAs possess coding potential; however, not all of them can truly encode peptides. Therefore, a practical strategy to scan for coding circRNAs is needed.Method: Sequence analyses included open reading frame (ORF) prediction, coding peptide prediction, and the identification of unique sequences. Then, experimental assays were used to verify the coded peptides, liquid chromatography-tandem mass spectrometry (LC-MS/MS) was introduced to detect sequences of circRNAs with coding potential, and Western blot was used to identify the encoded peptides. Finally, the functions of the circRNAs were primarily explored.Result: An efficient strategy for searching circRNAs with coding potential was created. We verified this schedule using public databases and LC-MS/MS, then two of these circRNAs were selected for further verification. We used commercial antibodies that can also identify the predicted peptides to test the coded peptides. The functions of the circRNAs were explored primarily, and the results showed that they were mainly involved in the promotion of proliferation and invasion ability.Discussion: We have constructed an efficient strategy of scanning circRNAs with coding potential. Our strategy helped to provide a more convenient pathway for identifying circRNA-derived peptides, which can be a potential therapeutic target or a diagnostic biomarker.
Correlation Between brGDGTs Distribution and Elevation From the Eastern Qilian Shan
Authors: Wang Hansheng , Gao Peng , Yang Rui , Nie Junsheng , Cao Bo , Zhou Aifeng , Pan Baotian , Chen Lin , Peng Tingjiang 
Published: February 2022

A clear understanding of the uplift history of the Tibetan Plateau is the key for correctly understanding its uplift mechanisms and impacts on the Asian environment. However, consensus has not been reached regarding the uplift history of the Tibetan Plateau, especially because of lack of well-calibrated paleoaltimetry proxies and lack of knowledge of how to correctly apply them to the past. Branched glycerol dialkyl glycerol tetraethers (brGDGTs) are a promising paleoaltimetry proxy because these large molecules tend to get preserved in sediments, and this proxy has a clear relationship with mean annual air temperature (MAAT), circumventing convoluted impact of precipitation or isotope variations on isotope-based paleoaltimetry proxies. As a result, many calibrations have been carried out linking brGDGTs with paleoelevation. Qilian Shan of the northeastern Tibetan Plateau is a key place testing previous models regarding the uplift model of the Tibetan Plateau. However, no modern calibration equation linking brGDGTs with MAAT is available. Here, we presented the first calibration equation between brGDGTs and MAAT from the eastern Qilian Shan with an elevation ranging from 2,055 to 3,300 m [MAAT = −15.50 + 49.55 × MBT′5ME (R2 = 0.89, p &lt; 0.001, RMSE = 1.07°C)]. We further established the calibration between MBT′5ME-derived MAAT and elevation. This dataset lays the foundation to understand the uplift history and environmental variations of the northeastern Tibetan Plateau area.
Correlates of Academic Performance in Online Higher Education: A Systematic Review
Authors: Chung Jennifer , McKenzie Stephen , Schweinsberg Ashleigh , Mundy Matthew Edward 
Published: February 2022

The existing steady and continual rise of online learning in higher education has been accelerated by COVID-19 and resulted in a move away from solely on-campus teaching. Prior to the pandemic, online education was providing higher education to students who were returning to study to up-skill, are employed full-time, caring for family members, living rurally or remotely and/or for whom otherwise face-to-face campus learning was not a preference or option. To understand how we can better support online students in their unique circumstances and create an optimal learning environment, we must understand the factors associated with academic achievement within an online setting. This systematic review involved a search of relevant databases published between January 2009 and May 2021 examining factors and constructs related to academic performance in online higher education settings. Across 34 papers, 23 (67.6%) explored factors and constructs related to student characteristics including cognitive and psychological, demographic, university enrolment, and prior academic performance. Twenty-one (61.8%) papers explored learning environment factors including engagement, student experience, course design, and instructor. Our overall synthesis of findings indicates that academic performance in online learning is most strongly associated with motivation (including self-efficacy), and self-regulation. We propose three main implications of our review for online learning stakeholders such as educators and designers. Firstly, we argue that the wellbeing of online learners is important to understand, and future research should explore its impact on students’ experience and success in online higher education. Secondly, we emphasise the importance of developing and designing online courses utilising relevant frameworks and evidence-based principles. Finally, we propose an approach to promoting improved student cognitive and psychosocial experiences (such as self-efficacy, self-regulation, and perceived support) could be achieved by creating and incorporating an online learning orientation module at the commencement of enrolment.Systematic Review Registration: (website), identifier (registration number).
Stability of Acid Black 210 dye in Tannery Industry Effluent in Aqueous Solution Is Limited and Generates Harmful Subproducts
Authors: Christovam Elisa Maria , Franco Jefferson Honorio , Zocolo Guilherme Julião , Fusco Almeida Ana Marisa , Marcelino Monica Yonashiro , de Oliveira Danielle Palma , Boldrin Zanoni Maria Valnice 
Published: February 2022

The present work investigates the occurrence of the Acid Black 210 (AB210) dye and its subproducts in the tannery industry by analytical techniques. The AB210 is an important dye characterized by three azo groups as a chromophore and is one of the most used azo dyes in the tannery industry. The stability of AB210 in front of chlorination, sunlight exposition, and ambient conditions was investigated, as well as its occurrence and degradation products in the tannery wastewater. The stability study of AB210 showed a decrease in dye concentration of up to 45% after 14 days at room temperature. The exposure of the AB 210 by a solar simulator for 3 h showed discoloration of the dye. Furthermore, the chlorination of the AB210 caused a reduction of 25% in the intensity of the absorption band at the visible region after 300 s of treatment with sodium hypochlorite (NaClO). Studies based on high-performance liquid chromatography (HPLC-DAD), liquid chromatography-mass spectrometry (LC-MS/MS), and nuclear magnetic resonance (NMR) have indicated the occurrence of several harmful compounds such as benzene, cresol, naphthalene, phenol, 2-naphthylamine, and phenylacetic acid, and three aromatic amines, 2-naphthylamine, 2,6-dimethylaniline and 4-nitroaniline from the tannery industry. The cytotoxicity assay showed toxicity for the samples stored for a long period. Thus, the immortalized human keratinocyte (HaCAT) and 3T3 cells assays for the AB210 stored for 14 days showed 70% cell death in both strains evaluated. Our results demonstrated that the AB210 degradation is a great environmental concern due to increased toxicity for the body of living beings, especially for humans, as their biotransformation produces harmful compounds such as amines, which have been widely condemned by the International Agency for Research on Cancer.
Panic, Psycho-Behavioral Responses, and Risk Perception in the Earliest Stage of the COVID-19 Pandemic in China
Authors: Zhang Weiyu , Zou Changqing , Sznajder Kristin K. , Cui Can , Fu Jiahui , He Shan , Peng Qinqi , Chen Qiongli , Yang Xiaoshi 
Published: February 2022

BackgroundCoronavirus Disease-19 (COVID-19), a rising global pandemic, has triggered psychological crises among the public. Panic, a severe symptom of mental disorders, is increasing in the public in China and it is urgent to provide research for intervention development.ObjectivesThis study aimed to assess the prevalence of public panic in China during the earliest stage of the COVID-19 pandemic and to explore the associated psychological behavioral responses and public's risk perception of the pandemic.MethodsA cross-sectional study using a web-based survey with convenience sampling was conducted with 2,484 participants nationally from February 11 to February 24, 2020 in China. A self-developed questionnaire was applied to assess the prevalence of public panic and its associated factors. Multivariable logistic regression analysis was applied to assess the risk and protective factors of public panic.ResultsThere were 23.39% (581/2,484) of the participants who reported experiencing panic during the earliest stage of the COVID-19 pandemic. Taking temperature repeatedly, being nervous in a crowd, being suspicious of infection in the family, being worried about the future, and worries about high infectivity of the COVID-19, lack of effective therapies, and wide impact of the COVID-19 pandemic increased the odds of public panic. Whereas, avoiding gatherings during holidays was negatively associated with the odds of public panic.ConclusionsPsycho-behavioral responses were closely associated with public panic during the earliest stage of the COVID-19 pandemic in China. Defusing excessive health-related worries, the guidance of appropriate self-protective behaviors, strengthening of health education in communities, and available treatment for mental disorders should be adopted to monitor the psychological responses and to guide the behaviors of the public.