bluuebunny/crossref_metadata_2025_split huggingface dataset:
TiRobot-assisted percutaneous kyphoplasty in the management of multilevel (more than three levels) osteoporotic vertebral compression fracture
Authors: Lin Shu , Tang Liu-yi , Wang Fei , Yuan Xin-wei , Hu Jiang , Liang Wei-min 
Published: September 2022

Abstract

Purpose
To compare the effectiveness of TiRobot-assisted kyphoplasty with that of the traditional fluoroscopy-assisted approach in treating multilevel osteoporotic vertebral compression fractures.

Methods
In this retrospective study, we collected data from 71 patients (TiRobot-assisted group, n = 39; fluoroscopy-assisted group, n = 32) with multilevel osteoporotic vertebral compression fracture treated with unilateral traditional TiRobot-assisted or fluoroscopy-assisted percutaneous kyphoplasty. The operative time, infusion volume, length of stay (LOS), hospital expenses, visual analog scale (VAS), Oswestry Disability Index (ODI), radiation exposure, puncture deviation, anterior height of diseased vertebrae, local kyphotic angle, bone cement distribution, and bone cement leakage were compared between the TiRobot- and fluoroscopy-assisted groups.

Results
Of the 257 treated vertebrae, the average amount of bone cement injected in the TiRobot-assisted (142 vertebrae) and fluoroscopy-assisted (115 vertebrae) groups was 4.6 mL and 4.5 mL, respectively. The VAS score was significantly lower in the TiRobot-assisted group at 24 hours post-operatively (p = 0.006). The X-ray frequency was 34.7 times in the TiRobot-assisted group and 51.7 times in the fluoroscopy-assisted group (p < 0.001). In addition to the operative time, cumulative radiation dose for the surgeon and patient was significantly lower in the TiRobot-assisted group. The hospital expenses of the TiRobot-assisted group were significantly higher (p < 0.001). The puncture deviation and bone cement distribution were better in the TiRobot-assisted group (p < 0.001). Bone cement leakage was found in 18 and 29 cases in the TiRobot- and fluoroscopy-assisted groups, respectively (p = 0.010). One patient in the fluoroscopy-assisted group experienced radiculopathy due to a misplaced puncture but recovered in three months. No radiculopathy was observed in the TiRobot-assisted group.

Conclusions
TiRobot-assisted percutaneous multilevel kyphoplasty is more accurate and has smaller radiometry, a more uniform bone cement distribution, and lower bone cement leakage. This method was therefore accurate and safe.
Investigating the causal risk factors for self-harm by integrating Mendelian randomisation within twin modelling
Authors: Lim Kai Xiang , Oginni Olakunle Ayokunmi , Rimfeld Kaili , Pingault Jean-Baptiste , Rijsdijk Frühling 
Published: September 2022

AbstractPrevious genetically informed studies have uncovered likely causal relationships between mental health problems and self-harm but resulting causal estimates may be biased due to unmediated pleiotropy. By fitting Mendelian Randomization - Direction of Causation (MR-DoC) models that explicitly model pleiotropy, we investigated the effect of four quantitatively measured mental health problems - major depressive disorder (MDD), schizophrenia, attention-deficit hyperactivity disorder (ADHD), and insomnia, on non-suicidal self-harm (NSSH) and suicidal self-harm (SSH), separately. We used data of 12,723 twins (56.6% females) in the Twins Early Development Study. Besides substantial pleiotropy, we found effects from child-rated depressive symptoms to both NSSH (β = 0.194, 95% CIs: 0.131, 0.257) and SSH (β = 0.210, 95% CIs: 0.125, 0.295). Similarly, effects flowed from parent-rated depressive symptoms to NSSH (β = 0.092, 95% CIs: 0.004, 0.181) and SSH (β = 0.165, 95% CIs: 0.051, 0.281). We did not find evidence of aetiological difference between NSSH and SSH.
The Acid Sphingomyelinase Inhibitor Amitriptyline Ameliorates TNF-α-Induced Endothelial Dysfunction
Authors: Ji Yang , Chen Jing , Pang Lihua , Chen Changnong , Ye Jinhao , Liu Hao , Chen Huanzhen , Zhang Songhui , Liu Shaojun , Liu Benrong , Cheng Chuanfang , Liu Shiming , Zhong Yun 
Published: September 2022

Abstract
Purpose
Inflammation associated endothelial cell (EC) dysfunction is key to atherosclerotic disease. Recent studies have demonstrated a protective role of amitriptyline in cardiomyocytes induced by hypoxia/reoxygenation. However, the mechanism by which amitriptyline regulates the inflammatory reaction in ECs remains unknown. Thus, the aim of this study was to investigate whether amitriptyline protects against inflammation in TNF-α-treated ECs.

Methods
HUVECs were incubated with amitriptyline (2.5 μM) or TNF-α (20 ng/ml) for 24 h. EdU, tube formation, transwell, DHE fluorescence staining, and monocyte adhesion assays were performed to investigate endothelial function. Thoracic aortas were isolated from mice, and vascular tone was measured with a wire myograph system. The levels of ICAM-1, VCAM-1, MCP-1, phosphorylated MAPK and NF-κB were detected using western blotting.

Results
Amitriptyline increased the phosphorylation of nitric oxide synthase (eNOS) and the release of NO. Amitriptyline significantly inhibited TNF-α-induced increases in ASMase activity and the release of ceramide and downregulated TNF-α-induced expression of proinflammatory proteins, including ICAM-1, VCAM-1, and MCP-1 in ECs, as well as the secretion of sICAM-1 and sVCAM-1. TNF-α treatment obviously increased monocyte adhesion and ROS production and impaired HUVEC proliferation, migration and tube formation, while amitriptyline rescued proliferation, migration, and tube formation and decreased monocyte adhesion and ROS production. Additionally, we demonstrated that amitriptyline suppressed TNF-α-induced MAPK phosphorylation as well as the activity of NF-κB in HUVECs. The results showed that the relaxation response of aortic rings to acetylcholine in the WT-TNF-α group was much lower than that in the WT group, and the sensitivity of aortic rings to acetylcholine in the WT-TNF-α group and WT-AMI-TNF-α group was significantly higher than that in the WT-TNF-α group.

Conclusion
These results suggest that amitriptyline reduces endothelial inflammation, consequently improving vascular endothelial function. Thus, the identification of amitriptyline as a potential strategy to improve endothelial function is important for preventing vascular diseases.
Modification of nanocellulose films in deep eutectic solvents using vinyl esters
Authors: Lakovaara Matias , Sirviö Juho Antti , Sliz Rafal , Vida Július , Homola Tomáš , Liimatainen Henrikki 
Published: September 2022

AbstractThe hydrophilicity of nanocellulose materials mitigates their good mechanical and oxygen barrier properties when exposed to humid conditions. It also limits nanocellulose use in many applications where water is present. This study reveals hydrophobic modification of cellulose nanofiber (CNF) films with vinyl esters of variable alkyl chain length using deep eutectic solvent (DES) of imidazole and triethylmethylammonium chloride as a reaction medium. Additionally, the influence of ultraviolet-ozone (UV/O3) pretreatment on CNF film modification in DES was addressed. The esterification of CNF films in DES was proven to be a simple and fast approach to increase the hydrophobicity of the films (increasing the contact angle from 38° to 107°), requiring only a 15 min reaction time and reaction temperature of 80 °C. Moreover, the modification improved water vapor barrier properties of the films and resulted in improved mechanical properties at wet state, especially with films treated with UV and ozone before modification.
Thermal Pressure in the Thermal Equation of State for Solid and a Proposed Substitute
Authors: Yan Jinyuan , Yang Shizhong 
Published: September 2022

AbstractThe thermal equation of state (TEOS) for solids is a mathematic model among pressure, temperature and density, and is essential for geophysical, geochemical, and other high pressure–temperature (high P–T) researches. However, in the last few decades, there has been a growing concern about the accuracy of the pressure scales of the calibrants, and efforts have been made to improve it by either introducing a reference standard or building new thermal pressure models. The existing thermal equation of state,P(V,T) = P(V,T0) + Pth(V,T), consists of an isothermal compression and an isochoric heating, while the thermal pressure is the pressure change in the isochoric heating. In this paper, we demonstrate that, for solids in a soft pressure medium in a diamond anvil cell, the thermal pressure can neither be determined from a single heating process, nor from the thermal pressure of its calibrant. To avoid the thermal pressure, we propose to replace the thermal pressure with a well-known thermal expansion model, and integrate it with the isothermal compression model to yields a Birch–Murnaghan-expansion TEOS model, called VPT TEOS. The predicted pressure of MgO and Au at ambient pressure from Birch–Murnaghan-expansion VPT TEOS model matches the experimental pressure of zero (0) GPa very well, while the pressure prediction from the approximated Anderson PVT TEOS exhibit a big deviation and a wrong trend.
Extending the Theory of Planned Behavior in the Social Commerce Context: A Meta-Analytic SEM (MASEM) Approach
Authors: Leong Lai-Ying , Hew Teck-Soon , Ooi Keng-Boon , Metri Bhimaraya , Dwivedi Yogesh K. 
Published: September 2022

Abstract
The theory of planned behavior (TPB) is popular in social commerce research, but existing studies have yielded inconclusive and inconsistent findings. As TPB was developed before the introduction of the Internet, Web 2.0 technologies, and social media, it is time to evaluate whether its relevance, effectiveness, novelty, and parsimony may have deteriorated due to temporal factors and the emergence of new Information Systems (IS) artifacts. In this work, an extended TPB2 is proposed by integrating social support, and MASEM analysis was conducted using a pooled correlation matrix. The findings revealed that TPB2 can better capture the nature of social commerce, as it can explain 28.4% of the variance in attitude, 59.0% of the variance in behavioral intention, and 9% of the variance in use behavior. In addition, it indicates that masculinity and uncertainty avoidance are the most significant Hofstedian cultural dimensions. The theoretical and managerial implications are also discussed along with the research agenda.
Dislocation-mediated and twinning-induced plasticity of CoCrFeMnNi in varying tribological loading scenarios
Authors: Dollmann Antje , Kauffmann Alexander , Heilmaier Martin , Srinivasan Tirunilai Aditya , Mantha Lakshmi Sravani , Kübel Christian , Eder Stefan J. , Schneider Johannes , Greiner Christian 
Published: September 2022

AbstractCoarse-grained, metallic materials undergo microstructure refinement during tribological loading. This in turn results in changing tribological properties, so the microstructural evolution is a parameter which should not be underestimated while designing tribological systems. Single-trace experiments were conducted to understand the initiation of deformation mechanisms acting in various tribological systems. The main scope of this work was to investigate the influence of normal and friction forces as well as crystal orientations on the dominating deformation mechanism in a face-centred cubic concentrated solid solution. While varying the normal force is easily realised, varying friction forces were achieved by using several counter body materials paired against CoCrFeMnNi. The subsurface deformation layer was either mediated through dislocation slip or twinning, depending on the grain orientation and on the tribological system. A layer dominated by dislocation-based deformation is characterised by lattice rotation, the formation of a dislocation trace line or subgrain formation. Such behaviour is observed for tribological systems with a low friction coefficient. For systems dominated by deformation twinning, three types of twin appearance were observed: small twins interacting with the surface, large twins and grains with two active twin systems. Two different twinning mechanisms are discussed as responsible for these characteristics.
Graphical abstract
Urban regeneration through retrofitting social housing: the AURA 3.1 prototype
Authors: Herrera-Limones Rafael , Hernández-Valencia Miguel , Roa-Fernández Jorge 
Published: September 2022

AbstractAs a large proportion of housing stock does not meet the current demands for energy and comfort (leading to high levels of obsolescence and vulnerability), the annual rate of energy upgrades for the existing stock must be increased. The AURA Strategy is an intervention methodology which focuses on the regeneration of neighbourhoods or obsolete urban fabrics which suffer from high levels of architectural, urban and socio-economic vulnerability. Within this context, the AURA 3.1 prototype was developed for the Solar Decathlon Europe 2019 Competition. The project was based around a sustainable construction strategy for the urban regeneration of obsolete residential neighbourhoods, through the reuse of existing buildings considering Mediterranean climate and energy. The Poligono San Pablo neighbourhood was chosen as the case study. This article presents the main retrofit action: the juxtaposition on the existing building of a structural-architectural system which provides new technological and spatial features. Quantitative data regarding the validity and effectiveness of the AURA Strategy could be collected from the monitoring of the Pavilion prototype during the competition. Two first prizes were won in contests with on-site measurements: Comfort conditions and House Functioning. Third place was also obtained in the Sustainability contest, thus confirming the enormous possibilities the AURA Strategy has for sustainable urban regeneration in retrofitting social housing, within the limitations of the competition.
Identification and Characterisation of Trajectories of Sickness Absence Due to Musculoskeletal Pain: A 1-Year Population-based Study
Authors: Rysstad Tarjei , Grotle Margreth , Aasdahl Lene , Dunn Kate M. , Tveter Anne Therese 
Published: September 2022

AbstractPurpose This study aimed to identify trajectories of sickness absence in workers on sick leave due to musculoskeletal disorders and explore the association between these trajectories and established prognostic factors for sickness absence. Methods We conducted a prospective cohort study of 549 workers (56% women, aged 18–67 years) on sick leave due to musculoskeletal disorders in Norway in 2018–2019. Sickness absence data were collected from the Norwegian sick leave registry and prognostic factors via self-reported baseline questionnaires. We used group-based trajectory modelling to define the different trajectories of sickness absence spanning a 1-year period. Multivariable multinomial logistic regression was used to estimate odds ratios and 95% confidence intervals for prognostic factors associated with the identified trajectory groups. Results We identified six distinct trajectories of sickness absence over 1 year: ‘fast decrease’ (27% of the cohort): ‘moderate decrease’ (22%); ‘slow decrease’ (12%); ‘u-shape’ (7%); ‘persistent moderate’ (13%); and ‘persistent high’ (18%). Prognostic factors, such as previous sickness absence days, return-to-work expectancy, workability, multisite pain, and health scores, differentiated between the sickness absence trajectories (all P < 0.05). Negative return-to-work expectancy was associated with the three trajectory groups with the highest number of sickness absence days (‘slow decrease’, ‘persistent moderate’, and ‘persistent high’). Conclusions This is the first study to explore the association of return-to-work expectancy with trajectories of sickness absence. Our findings highlight different patterns of sickness absence and the complex range of prognostic factors. These findings have implications for secondary and tertiary prevention strategies for work absence in workers with musculoskeletal disorders.
ON SOLID CORES AND HULLS OF WEIGHTED BERGMAN SPACES $$A_{\mu }^1$$
Authors: Bonet José , Lusky Wolfgang , Taskinen Jari 
Published: September 2022

AbstractWe consider weighted Bergman spaces $$A_\mu ^1$$

A
μ
1

on the unit disc as well as the corresponding spaces of entire functions, defined using non-atomic Borel measures with radial symmetry. By extending the techniques from the case of reflexive Bergman spaces, we characterize the solid core of $$A_\mu ^1$$

A
μ
1

. Also, as a consequence of a characterization of solid $$A_\mu ^1$$

A
μ
1

-spaces, we show that, in the case of entire functions, there indeed exist solid $$A_\mu ^1$$

A
μ
1

-spaces. The second part of the article is restricted to the case of the unit disc and it contains a characterization of the solid hull of $$A_\mu ^1$$

A
μ
1

, when $$\mu$$
μ
equals the weighted Lebesgue measure with the weight v. The results are based on the duality relation of the weighted $$A^1$$

A
1

- and $$H^\infty$$

H
∞

-spaces, the validity of which requires the assumption that $$-\log v$$

-
log
v

belongs to the class $$\mathcal {W}_0$$

W
0

, studied in a number of publications; moreover, v has to satisfy the condition (b), introduced by the authors. The exponentially decreasing weight $$v(z) = \exp ( -1 /(1-|z|)$$

v
(
z
)
=
exp
(
-
1
/
(
1
-
|
z
|
)

provides an example satisfying both assumptions.
Characterization of phenylalanine hydroxylase gene variants and analysis of genotype–phenotype correlation in patients with phenylalanine hydroxylase deficiency from Fujian Province, Southeastern China
Authors: Zhou Jinfu , Zeng Yinglin , Qiu Xiaolong , Lin Qingying , Chen Weifeng , Luo Jinying , Xu Liangpu 
Published: September 2022

Abstract
Background
Phenylalanine hydroxylase deficiency (PAHD) is the most prevalent inherited disorder of amino acid metabolism in China. Its complex phenotype includes many variants and genotypes among different populations.

Methods and results
In this study, we analyzed the phenylalanine hydroxylase gene (PAH) variants in a cohort of 93 PAHD patients from Fujian Province. We also assessed genotype and phenotype correlation in patients with PAHD. A total of 44 different pathogenic variants were identified, including five novel variants. The three most prevalent variants among all patents were c.158G > A, p.(Arg53His) (18.03%), c.721C > T, p.(Arg241Cys) (14.75%), and c.728G > A, p.(Arg243Gln) (7.65%). The frequency of the c.158G > A, p.(Arg53His) variant was highest in patients with mild hyperphenylalaninemia, whereas the frequency of the c.1197A > T, p.(Val399 =) and c.331C > T, p.(Arg111Ter) variants was highest in patients with classic phenylketonuria. The most abundant genotypes observed in PAHD patients were c.[158G > A];[728G > A], c.[158G > A];[442-1G > A], and c.[158G > A];[721C > T]. Comparing allelic phenotype to genotypic phenotype values yielded fairly accurate predictions of phenotype, with an overall consistency rate was 85.71% for PAHD patients.

Conclusions
Our study identified a PAH variant spectrum in PAHD patients from Fujian Province, Southeastern China. Quantitative correlation analysis between genotype and phenotype severity is helpful for genetic counseling and management.
Using immersive technologies to facilitate location scouting in audiovisual media production: a user requirements study and proposed framework
Authors: Bodini Aimone , Colecchia Federico , Manohar Arthi , Harrison David , Garaj Vanja 
Published: September 2022

AbstractIn common with many industries, the audiovisual sector is likely to be transformed by real-time graphic engines in combination with immersive technologies such as Virtual Reality and Augmented Reality. This technological mix enables what is presently known as Virtual Production, introducing a new process to the audiovisual professional, capable of fostering creativity, collaboration, and decision making, while at the same time increasing efficiency. The potential for Virtual Production to transform workflows and creative processes within large-scale productions in the audiovisual sector is significant and includes the prospective introduction of new capabilities for remote co-creation of content. However, barriers to democratisation need to be overcome, particularly in relation to adoption of the technology by small and medium independent productions that generally have limited access to resources and technical knowledge. Following an extensive study of the current literature and involvement in the research of professionals working in the field through online interviews, this article documents a first step towards filling this gap by investigating Virtual Production adoption scenarios for small and medium independent productions. The primary aim is to design intuitive, engaging, and effective solutions to address the needs of Directors, Cinematographers, and Producers.Thanks to the valuable time and experience of industry professionals, this study has gathered user requirements for a Virtual Production design solution capable of facilitating location scouting and pre-production. A novel framework for remote exploration of target locations within immersive environments, co-created with relevant stakeholders, is presented to lay the foundations of future co-design work.
Pretreatment of the ROS Inhibitor Phenyl-N-tert-butylnitrone Alleviates Sleep Deprivation-Induced Hyperalgesia by Suppressing Microglia Activation and NLRP3 Inflammasome Activity in the Spinal Dorsal Cord
Authors: Huang Yulin , Hao Jing , Yang Xuli , Xu Li , Liu Yue , Sun Yu’e , Gu Xiaoping , Zhang Wei , Ma Zhengliang 
Published: September 2022

AbstractSleep deprivation, a common perioperative period health problem, causes ocular discomfort and affects postsurgical pain. However, the mechanism of sleep deprivation-induced increased pain sensitivity is elusive. This study aims to explore the role of ROS in sleep deprivation (SD)-induced hyperalgesia and the underlying mechanism. A 48-h continuous SD was performed prior to the hind paw incision pain modeling in mice. We measured ROS levels, microglial activation, DNA damage and protein levels of iNOS, NLRP3, p-P65 and P65 in mouse spinal dorsal cord. The involvement of ROS in SD-induced prolongation of postsurgical pain was further confirmed by intrathecal injection of ROS inhibitor, phenyl-N-tert-butylnitrone (PBN). Pretreatment of 48-h SD in mice significantly prolonged postsurgical pain recovery, manifesting as lowered paw withdrawal mechanical threshold and paw withdrawal thermal latency. It caused ROS increase and upregulation of iNOS on both Day 1 and 7 in mouse spinal dorsal cord. In addition, upregulation of NLRP3 and p-P65, microglial activation and DNA damage were observed in mice pretreated with 48-h SD prior to the incision. Notably, intrathecal injection of PBN significantly reversed the harmful effects of SD on postsurgical pain recovery, hyperalgesia, microglial activation and DNA damage via the NF-κB signaling pathway. Collectively, ROS increase is responsible for SD-induced hyperalgesia through activating microglial, triggering DNA damage and enhancing NLRP3 inflammasome activity in the spinal dorsal cord.