bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Morphological Evaluation of Erosive and Ulcerative Gastric
Lesions in Patients with Rheumatoid Arthritis
Authors: Beloglazov Vladimir , Petrov Andrey , Kaliberdenko Vitalii , Abramova Kseniya , Shanmugaraj Kulanthaivel 
Published: May 2022

Background:
One of the most important problem associated with treatment of the rheumatoid arthritis (RA) is erosive-ulcerative lesions (EUL) of the gastroduodenal zone, which is associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs).

Aim:
Aim of our research is to study the clinical and histo-morphological criteria for the formation of the EUL of the gastroduodenal zone in patients with RA.

Methods:
Patients were divided into 3 groups, depending on the presence of an EUL, according to fibrogastroduodenoscopy (FGDS) data with a negative test for H. pylori. Group 1 included RA patients without EUL (n = 18), group 2 RA patients with erosive lesions of the gastroduodenal zone (n = 57), group 3 consisted of RA patients with ulcerative lesions (n = 17). As a norm, we used data from a survey of 18 healthy donors corresponding to RA patient’s age and sex distribution, where no somatic pathology was revealed. GSRS questionnaire used for assessment of subjective symptoms. For histomorphological studies, biopsy specimens were taken during FGDS using an Olympus Evis Exera II digital video endoscope.

Results:
Patients of RA with EUL of gastro-duodenal zone were significantly different from the group of healthy donors and patients of group 1, by the severity of 5 symptoms related to the upper gastrointestinal tract according to the GSRS questionnaire, including abdominal pain, heartburn, belching acid, a feeling of sucking and burning in epigastria, nausea and vomiting. In general, there were no clinically significant differences between the frequency of occurrence and the severity of symptoms on the GSRS scale between group 2 and group 3, except for complaints of heartburn. So, RA patients of group 3 had a higher rate of heartburn feeling of 3.0 (2.0-3.0) points than patients of group 2 with 2.0 (1.0-2.0) points.

Conclusion:
The development of a EUL of gastroduodenal zone in patients with RA is associated with low activity of inflammation in all studied slides, regardless of structurally destructive changes in the stomach and duodenum, and compensatory hyperplastic reactions in the superficial layer of mucosa membrane, which can be determined by minimal subjective sensations or even complete absence of clinical manifestations with the formation of “silent ulcers”, complicated by bleeding and perforation.
Development of a Nomogram for Predicting Asymptomatic Coronary
Artery Disease in Patients with Ischemic Stroke
Authors: Long Youming , Yang Jie , Yang Xinguang , Wen Jun , Huang Jiayi , Jiang Lihong , Liao Sha , Lian Chun , Yao Haiyan , Huang Li 
Published: May 2022

Background:
Coronary artery stenosis (CAS) ≥50% often coexists in patients with ischemic
stroke, which leads to a significant increase in the occurrence of major vascular events after
stroke. This study aimed to develop a nomogram for diagnosing the presence of ≥50% asymptomatic
CAS in patients with ischemic stroke.

Methods:
A primary cohort was established that included 275 non-cardioembolic ischemic stroke
patients who were admitted from January 2011 to April 2013 to a teaching hospital in southern China.
The preoperative data were used to construct two models by the best subset regression and the
forward stepwise regression methods, and a nomogram between these models was established. The
assessment of the nomogram was carried out by discrimination and calibration in an internal cohort.

Result:
Out of the two models, model 1 contained eight clinical-related variables and exhibited the
lowest Akaike Information Criterion value (322.26) and highest concordance index 0.716 (95% CI,
0.654-0.778). The nomogram showed good calibration and significant clinical benefit according to
calibration curves and the decision curve analysis.

Conclusion:
The nomogram, composed of age, sex, NIHSS score on admission, hypertension history,
fast glucose level, HDL cholesterol level, LDL cholesterol level, and presence of ≥50% cervicocephalic
artery stenosis, can be used for prediction of ≥50% asymptomatic coronary artery disease
(CAD). Further studies are needed to validate the effectiveness of this nomogram in other populations.
Graph Neural Networks in Biomedical Data: A Review
Authors: Li You , Zhang Guiyang , Wang Pan , Yu Zuo-Guo , Huang Guohua 
Published: May 2022

Abstract:
With the development of sequencing technology, various forms of biomedical data, including
genomics, transcriptomics, proteomics, microbiomics, and metabolomics data, are increasingly emerging.
These data are an external manifestation of cell activity and mechanism. How to deeply analyze
these data is critical to uncovering and understanding the nature of life. Due to the heterogeneousness
and complexity of these data, it is a vastly challenging task for traditional machine learning to deal with
it. Over the recent ten years, a new machine learning framework called graph neural networks (GNNs)
has been proposed. The graph is a very powerful tool to represent a complex system. The GNNs is becoming
a key to open the mysterious door of life. In this paper, we focused on summarizing state-ofthe-
art GNNs algorithms (GraphSAGE, graph convolutional network, graph attention network, graph
isomorphism network and graph auto-encoder), briefly introducing the main principles behind them. We
also reviewed some applications of the GNNs to the area of biomedicine, and finally discussed the possible
developing direction of GNNs in the future.
Outcome and Complications of Hemoperfusion in Patients with COVID-19 in Intensive Care Unit: A Cross-Sectional Study
Authors: Jazaeri Saeedehsadat Mousavizade , Darban Mahboobeh , Yarmohamadi Maliheh , Mohammadkhani Majid Mir 
Published: May 2022

Background & Objective:
The use of the hemoperfusion method is recommended for
treating cytokine storms and reducing complications in patients with COVID-19. The side effects
of this treatment are not known; therefore, this study was performed to determine the final outcome
and complications of hemoperfusion in patients with COVID-19 hospitalized in ICU.

Methods:
In this retrospective cross-sectional study, all patients with severe COVID-19 without
any comorbidities or organ failure underwent hemoperfusion treatment in ICU at Kosar Hospital
in Semnan, Iran, from March to November 2021 were included. The clinical data and short-term
complications up to 10 days after hemoperfusion and the final outcome were extracted from
medical files.

Results:
The mean age of 40 patients with severe COVID-19 undergoing hemoperfusion was
57.5±15.9 years. Most (24, 60%) patients were male. The time interval from hospitalization to
hemoperfusion and the time interval between hemoperfusion and final outcome was 4.85 days
and 8.30 days, respectively. Arrhythmia, bleeding, thrombocytopenia, and coagulation disorders
were the most common short-term complications of hemoperfusion in patients with COVID-19,
respectively. Most complications occurred on the second and third days after hemoperfusion.
Mortality occurred in 20 (50 %) patients with severe COVID-19 undergoing hemoperfusion in
ICU.

Conclusion:
It seems that the short-term complications and deaths due to hemoperfusion are relatively
high in patients with COVID-19 admitted to the ICU. Further studies are recommended.
Antihyperglycemic and Antidyslipidemic Effect of Moricandia Suffruticosa in Normal and Streptozotocin-induced Diabetic Rats
Authors: Eddouks Mohamed , Azzane Amine , Amssayef Ayoub 
Published: May 2022

Aims of the Study:The present work aimed to assess the antihyperglycemic and antihy-perlipidemic effects of Moricandia suffruticosa.Background:Moricandia suffruticosa (M. suffruticosa) is used in traditional medicine.Objective:The present study investigated the antihyperglycemic and antidyslipidemic effects of M. suffruticosa and its effect on glycogen content in normoglycemic and hyperglycemic rats.. Methods:The effect of the aqueous extract of M. suffruticosa (AEMS) at two doses of 100 and 140 mg/kg on blood glucose levels, lipid, lipoprotein profile, and glycogen content was examined in normal and streptozotocin (STZ)-induced diabetic rats. Moreover, preliminary phytochemical screening and quantification of phenolic, flavonoid, and tannin contents were carried out.Results:The results demonstrated that AEMS exhibits antihyperglycemic activity in diabetic rats during both acute and subchronic assays. Furthermore, AEMS revealed an antidyslipidemic effect concerning the level of triglycerides, total cholesterol, very-low-density lipoprotein (VLDL), and non-high-density lipoproteins (Non-HDL). In contrast, AEMS has not affected the value of glyce-mia, lipids, and lipoproteins in normal rats. In addition, AEMS is rich in several phytochemical compounds. Furthermore, AEMS revealed an important in vitro antioxidant activity.Conclusion:In conclusion, the study demonstrates that M. suffruticosa exhibits an important anti-hyperglycemic effect in diabetic rats.
Using Bacteria and Fungi as Plant Biostimulants for Sustainable
Agricultural Production Systems
Authors: Shahrajabian Mohamad Hesam , Cheng Qi , Sun Wenli 
Published: May 2022

Abstract:
Different compounds with bioactive constitutents can be applied as biostimulants to increase plant growth and development under both normal and stressful conditions. Biostimulants utilization can be considered as a sustainable and beneficial nutritional crop management, and may decrease the negative impacts associated with excessive chemical fertilization. Google scholar (scholar.google.com), Science Direct (sicencedirect.com), CAB Direct (cabdirect.org), Springer Link (springerlink.com), Scopus (scopus.com), Web of Science (web of knowledge.com), Taylor and Francis (tandfonline.com), and Wiley Online Library (onlinelibrary.wiley.com) have been checked. The search was done to all manuscript sections according to terms "Glomus intraradices", "Trichoderma atroviride", "Trichoderma reesei", "Heteroconium chaetospira", "Artherobacter spp.", "Acinetobacter spp.", "Enterobacer spp.", "Pseudomonas spp.", "Ochrobactrum spp.", "Bacilus spp.", "Rhodococcus spp.", "Biostimulants", and "Plant growth promotion". On the basis of initial check, Titles and Abstracts have been reviwed on the basis of online literature, and then articles were read carefully. Withinin the framework of sustainable crop management, this review article was aimed to provide an overview of the application of the most common fungi and bacteria as plant biostimulants on various crops.
Systemic Inflammation in Sarcopenia Alter Functional Capacity in Thai
Community-dwelling Older People: A Preliminary Observational Study
Authors: Yuenyongchaiwat Kornanong , Akekawatchai Chareeporn 
Published: May 2022

Background:
Sarcopenia is linked to the loss of muscle mass in older adults, leading to
impaired functional capacity and quality of life. In addition, this finding was recognized as an agerelated
chronic inflammatory process. We aimed to determine the relationship between sarcopenia,
functional capacity, and inflammatory biomarkers and subsequent prediction of inflammatory biomarkers
in older adults.

Methods:
A total of 126 women and men aged ≥ 60 years were enrolled. Participants were required
to complete a handgrip dynamometer, 6-meter walk test, and bioimpedance analysis. Diagnosis
was based on the definition of sarcopenia from the Asian Working Group for Sarcopenia
2019. Prior to performing a 6-minute walking test (i.e., functional capacity testing), blood samples
were drawn for a C-reactive protein (CRP) test.

Results:
A total of 12.70% were categorized as having sarcopenia. Significant differences in CRP
and functional capacity between the sarcopenia and non-sarcopenia groups were found (p <05).
Older people with high CRP levels had significantly reduced functional capacity and slow gait
speed.

Conclusions:
Poor functional capacity was associated with increased CRP levels, which might be
due to the development of age-related inflammation. Older patients with sarcopenia may be at
higher risk for functional decline.
Hydroxychloroquine and Mortality in SARS-Cov-2 Infection; the HOPECovid-
19 Registry
Authors: Ayerbe Luis , Núñez-Gil Iván J. , Fernandez-Pérez Cristina , Estrada Vicente , Eid Charbel Maroun , Arroyo-Espliguero Ramón , Romero Rodolfo , Becerra-Muñoz Víctor Manuel , Uribarri Aitor , Feltes Gisela , Trabattoni Daniela , Molina María , Aguado Marcos García , Pepe Martino , Cerrato Enrico , Huang Jia , Astrua Thamar Capel , Alfonso Emilio , Castro-Mejía Alex F. , Raposeiras-Roubin Sergio , Buzón Luis , Paeres Carolina Espejo , Mulet Alba , Lal-Trehan Nisha , Garcia-Vazquez Elisa , Fabregat-Andres Oscar , Akin Ibrahim , D´Ascenzo Fabrizio , Gomez-Rosado Paula , Ugo Fabrizio , Fernández-Ortiz Antonio , Macaya Carlos 
Published: May 2022

Background:
Hydroxychloroquine (HCQ) may be an effective, safe, and affordable treatment for
Covid-19 that can be used in selected patients. However, more evidence on its association when it is used in
different stages of the disease with clinical outcomes is required. This observational study investigates the
association between treatment with HCQ and mortality in patients with Covid-19.

Methods:
The data from 6217 patients who died or were discharged from 24 Spanish hospitals were
analyzed. Propensity matching scores (PMS) were used.

Results:
5094 patients received HCQ. Death was recorded for 17.5% of those who had HCQ and 34.1% of
those who did not have it. Mortality was lower for those who had HCQ, OR=0.41 (95% CI=0.34-0.48). The
PMS analysis also showed that mortality was lower for those receiving HCQ, OR=0.47 (95%CI=0.36-0.62).
PMS analysis for categories revealed an association between HCQ and lowered mortality for patients over
65 years of age, with a past medical history of hypertension, for those who were diagnosed during
admission with sepsis related organ failure or pneumonia, and for those with lymphocytopenia, raised
troponin, LDH, ferritin and D-dimer. No increase in mortality associated with HCQ was observed in any
category of any of the variables investigated.

Conclusions:
HCQ could be associated with lower mortality for older patients, those with more severe
disease and raised inflammatory markers. Further RCTs, observational studies, and summaries of both types
of evidence on this topic are necessary to select the precise profile of patients that may benefit from HCQ.
Similarity Measures and Their Applications in Multiple Attribute Decision-
Making Under Cubic Hesitant Environment
Authors: Belayneh Yohannes , Yong Rui , Zhang Yingying 
Published: May 2022

Background:
Cubic Hesitant Fuzzy Set (CHFS) is a hybrid set that can express uncertain
and hesitancy fuzzy information simultaneously.

Objective:
In this paper, we introduced three trigonometric similarity measures (e.g., cosine, tangent,
and cotangent similarity measures) to measure the degree of similarity between the alternative
and the ideal set under the CHFS environment. Various desirable characteristics of the cubic
hesitant fuzzy set are studied. Then, we developed multiple attribute decision-making methods
based on the weighted cosine, tangent, and cotangent similarity measures of CHFSs.

Methods:
In this research, we presented the similarity measures of CHFSs based on the cosine,
tangent, and cotangent functions. Then, illustrative examples of construction project management
with CHFS information are presented to show the effectiveness and feasibility of the proposed
Multiattribute Decision-making (MADM) method under CHFS environments.

Result:
Based on the weighted similarity measures between each alternative and the ideal set,
this method provides the ranking order according to the values of their similarity measure. The
best alternatives can be easily identified from the ranking order obtained.

Conclusion:
Based on the comparison of the decision results obtained, the tangent and cotangent
similarity measures are better in similarity identification than the cosine similarity measure for
solving MADM problems under a cubic hesitant environment.
Securing Hybrid Architecture of Cloudlet Computing in 5G Networks
Enabling IoT and Mobile Wireless Devices
Authors: Sobh Tarek S. , Khalil Awad H. 
Published: May 2022

Aims:
This research aims to secure and support mobile devices and IoTs enabled in WLAN and 5G Multi-Access Edge Computing (MEC) infrastructures.

Background:
Currently, wireless network access gains increasing potential in today's networks. At the same time, such ongoing wireless network access also raises the risk of network attacks. The 5G technology is expected to empower people inter-communications by integrating wireless networking technologies in all kinds of networks. Additionally, the emerging 5G technologies put forward many new requirements for RF characteristics and techniques regarding bandwidth and power issues, in addition to supporting high connectivity capacity for the emerging IP-based IoT applications.

Objective:
The objective is to provide a hybrid architecture of the proposed framework for a 5G network with cloudlet computing. The purpose that we are focusing on it is to support and monitor wireless networks under attack.

Methods:
The solution is done through a hybrid architecture. In this architecture, the cloudlet and Wi-Fi access points (AP) are integrated for providing an integrated Wi-Fi-enabled cloudlet. On the other hand, we have specified a solution for detecting unauthorized APs by using authentication and authorization techniques for securing communications among endpoint devices such as IoT devices or mobile devices, cloudlet, and the main cloud. A framework of this architecture has been developed to face the issue of securing IoT devices and mobile wireless devices.

Results:
The traffic sniffing and traffic filtering of the endpoints are done. Therefore, the required actions that define the organization's policy are applied through the permitted access list. In addition to a wireless network location, the management components use more than one authorized attribute value to generate the authorized list, such as SSID, MAC, BSSID …etc. Finally, Traffic analysis provides the user to get reports, statistics, and analysis charts of secure endpoints activities.

Conclusion:
We are focusing on one of the critical security issues of wireless networks. Namely, the issue of unauthorized access becomes more critical due to getting access to a network without subscriber permission. Moreover, the proposed solution allows managing access control permissions to allow or block access to resources for the user of a mobile device.
A State of the Art Review on User Behavioral Issues in Online Social
Networks
Authors: Patel Nidhi A. , Nanavati Nirali 
Published: May 2022

Abstract:
Social networks are aimed at information sharing and friend-making due to the rapid
development of Online Social Networks (OSN) and the increasing number of online users. The
OSNs are also becoming an ideal platform for merchandise recommendation, opinion expression,
information diffusion, and influence generation. Different types of social network services and
users select the appropriate social network technology, services, and applications to meet their
sociability, entertainment, or information retrieval needs. User behavior involves user
interaction, access, and browsing of the OSN. The users have different roles in different groups
of social networks. Different identifications of the user may cause the user's intention to change.
The user's intention may change as a result of different identifications. In this work, we discuss
an introduction to OSN, single and multi-platform user behavior with various prediction models
and recommendations.
Public Policies and Programs for the Prevention and Control of Breast Cancer in Latin American Women: Scoping Review
Authors: Ramos Herrera Igor Martín , Lemus Flores María Guadalupe , Reyna Sevilla Antonio , González Castañeda Miguel Ernesto , Torres Gutiérrez Fernando Adolfo , Crocker Sagastume René Cristóbal , Robles Pastrana Juan De Dios , Vázquez Castellanos José Luis 
Published: May 2022

Background
Breast cancer has positioned itself worldwide as one of the main public health problems, especially in Latin America. In some countries, several programs for the prevention and control of breast cancer in women have been developed and implemented on a permanent basis, but there are no public reports on the policies that originated such programs.

Objective
A scoping review of scientific publications that identify the type, extent, and scope of policies and programs for the prevention and control of breast cancer in Latin American women was performed, and the main results were presented in this paper.

Methods
This scoping review was carried out according to the method by Arksey and O’Malley based on 3 fundamental questions about breast cancer prevention and control policies in Latin America: their type, extent and scope, and reference framework. The search period was from 2000 to 2019, and the search was carried out in the following databases: MEDLINE (PubMed), MEDLINE (EbscoHost), CINAHL (EbscoHost), Academic Search Complete (EbscoHost), ISI Web of Science (Science Citation Index), and Scopus in English, Spanish, and Portuguese, and Scielo, Cochrane, and MEDES-MEDicina in Spanish and Portuguese. Of the 743 studies found, 20 (2.7%) were selected, which were analyzed using descriptive statistics and qualitative content analysis.

Results
The selected studies identified several Latin American countries that have generated policies and programs to prevent and control breast cancer in women, focusing mainly on risk communication, prevention and timely detection, effective access to health services, improvement of the screening process, and evaluation of screening programs. Evaluation criteria and greater participation of civil society in policy design and program execution are still lacking. This could undoubtedly help eliminate existing barriers to effective action.

Conclusions
Although several Latin American countries have generated public policies and action programs for the prevention and control of breast cancer, a pending issue is the evaluation of the results to analyze the effectiveness and impact of their implementation given the magnitude of the public health problem it represents and because women and civil society play an important role in its prevention and control.

International Registered Report Identifier (IRRID)
RR2-10.2196/12624