bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple intestinal lymphangiomas with episodic hemorrhage requiring partial laparoscopic resection: a case report
Authors: Kondo Hiroka , Ohki Takeshi , Ogawa Shimpei , Omori Teppei , Onizuka Hiromi , Nagashima Yoji , Yamaguchi Shigeki 
Published: March 2022

Abstract
Background
Lymphangioma is a non-epithelial tumor marked by aggregates of abnormally dilated lymphatics. Mesenteric occurrences account for < 1% of all cases, and < 0.05% involve the gastrointestinal tract. Most are confined to children, rarely affecting adults.

Case presentation
Herein, we describe an elderly Japanese woman with anemia, hypoalbuminemia, and episodic bleeding due to multiple intestinal lymphangiomas. Abdominal computed tomography revealed multiple low-density defects of mesentery, with areas of intermediate (T1 images) or high (T2 images) signal intensity similarly dispersed in magnetic resonance scanning sequences. Single-balloon enteroscopy was undertaken, enabling identification and tattooing of a small intestinal bleeding source. Laparoscopy-assisted resection at this site served to control related hemorrhage, removing a histologically confirmed hemolymphangioma. Having recovered uneventfully, the patient remained stable 2 months postoperatively.

Conclusions
Although rare in adults, mesenteric or gastrointestinal lymphangiomas must be considered in a setting of anemia and hypoalbuminemia. Complete resection is advantageous to improve patient symptoms, but limited resection of multiple lesions may be equally effective.
Electrical neurostimulation in glaucoma with progressive vision loss
Authors: Erb Carl , Eckert Sophie , Gindorf Pia , Köhler Martin , Köhler Thomas , Neuhann Lukas , Neuhann Thomas , Salzmann Nadja , Schmickler Stefanie , Ellrich Jens 
Published: March 2022

Abstract
Background
The retrospective study provides real-world evidence for long-term clinical efficacy of electrical optic nerve stimulation (ONS) in glaucoma with progressive vision loss.

Methods
Seventy glaucoma patients (45 to 86 y) with progressive vision loss despite therapeutic reduction of intraocular pressure (IOP) underwent electrical ONS. Closed eyes were separately stimulated by bipolar rectangular pulses with stimulus intensities up to 1.2 mA sufficient to provoke phosphenes. Ten daily stimulation sessions within 2 weeks lasted about 80 min each. Right before ONS at baseline (PRE), vision loss was documented by static threshold perimetry and compared to the same assessment approximately 1 year afterwards (POST). Mean defect (MD) was defined as primary outcome parameter. Perimetries with a reliability factor (RF) of max. 20% were considered.

Results
Perimetry follow-up of 101 eyes in 70 patients fulfilled the criterion of a max. 20% RF. Follow-up was performed on average 362.2 days after ONS. MD significantly decreased from PRE 14.0 dB (median) to POST 13.4 dB (p < 0.01). 64 eyes in 49 patients showed constant or reduced MD as compared to baseline (PRE 13.4 dB vs. POST 11.2 dB). In 37 eyes of 30 patients, MD increased from PRE 14.9 dB to POST 15.6 dB.

Conclusions
Innovative treatments that preserve visual function through mechanisms other than lowering IOP are required for glaucoma with progressive vision loss. The present long-term data document progression halt in more than 63% of affected eyes after ONS and, thus, extend existing evidence from clinical trials.
Convergent Synthesis of the HIJKLMN-Ring Fragment of Caribbean Ciguatoxin C-CTX-1 by a Late-Stage Reductive Olefin Coupling Approach
Authors: Sasaki Makoto , Iwasaki Kotaro , Arai Keisuke , Hamada Naoya , Umehara Atsushi 
Published: March 2022

Abstract
The convergent synthesis of the HIJKLMN-ring fragment of Caribbean ciguatoxin C-CTX-1, the major causative toxin for ciguatera fish poisoning in the Caribbean Sea and the Northeast Atlantic areas, is disclosed. The synthesis features a late-stage iron-catalyzed hydrogen atom transfer-initiated reductive olefin coupling to install the N-ring and a Suzuki–Miyaura coupling/thioacetalization strategy for the convergent assembly of the hexacyclic HIJKLM-ring skeleton.
Exercise Is Medicine for Underserved and Vulnerable Populations: Factors Influencing Implementation
Authors: Vermeesch Amber L. , Bustamante Eduardo E. , Coleman Nailah , Goldsby TaShauna , Hasson Rebecca E. , Hooker Steven P. , Marquez David X. , Conroy Molly B. 
Published: March 2022

ABSTRACT

Purpose
Communities of underserved and vulnerable populations (UVP) are particularly at risk for the negative health consequences related to inadequate physical activity. UVP include individuals from the following groups: racial and ethnic minorities, individuals with disability, those from rural and inner-city areas, elderly and pediatric populations, undocumented immigrants and political refugees, the uninsured/underinsured, those with low income, individuals with chronic medical conditions, non-English-speaking populations, and those with limited health literacy. Exercise Is Medicine (EIM®), launched in 2007 by the American College of Sports Medicine (ACSM) and the American Medical Association®, is a population health initiative aimed at assessing and promoting physical activity among all populations in the United States. The rationale for this commentary is to describe challenges in implementing EIM® in UVP, discuss potential solutions to these challenges, and share lessons learned from a decade of work in this area to maximize the impact of EIM® in UVP and thereby increase physical activity levels in UVP.

Methods
The ACSM Underserved and Community Health Committee developed a series of symposia presented at the ACSM Annual Meetings in 2012, 2014, 2016, and 2018 to address EIM® in UVP in terms of barriers, opportunities, health policy, dissemination, and implementation. These symposia included both committee members and other national experts in relevant fields of health disparities, health policy, implementation science, and health care delivery. Symposia highlights and relevant updates were collated by a writing group of committee members for this commentary and organized by applying the Socioecological Model (i.e., individual, relationship, community, societal levels).

Results
Recommendations regarding best practices for EIM® dissemination and implementation among UVP are presented for healthcare providers, exercise professionals, and patients. Key findings include the importance of tailoring EIM® interventions to improve service to UVP and increase their access to EIM® resources.

Conclusion
For EIM® to achieve its aim of moving the needle on population health by increasing activity, it will need continued focus on EIM® implementation among UVP communities with the highest rates of chronic disease and the lowest rates of physical activity.
Machine-learning-based radiomics identifies atrial fibrillation on the epicardial fat in contrast-enhanced and non-enhanced chest CT
Authors: Zhang Lu , Xu Zhihan , Jiang Beibei , Zhang Yaping , Wang Lingyun , de Bock Geertruida H , Vliegenthart Rozemarijn , Xie Xueqian 
Published: March 2022

Objective: The purpose is to establish and validate a machine-learning-derived radiomics approach to determine the existence of atrial fibrillation (AF) by analyzing epicardial adipose tissue (EAT) in CT images. Methods: Patients with AF based on electrocardiographic tracing who underwent contrast-enhanced (n = 200) or non-enhanced (n = 300) chest CT scans were analyzed retrospectively. After EAT segmentation and radiomics feature extraction, the segmented EAT yielded 1691 radiomics features. The most contributive features to AF were selected by the Boruta algorithm and machine-learning-based random forest algorithm, and combined to construct a radiomics signature (EAT-score). Multivariate logistic regression was used to build clinical factor and nested models. Results: In the test cohort of contrast-enhanced scanning (n = 60/200), the AUC of EAT-score for identifying patients with AF was 0.92 (95%CI: 0.84–1.00), higher than 0.71 (0.58–0.85) of the clinical factor model (total cholesterol and body mass index) (DeLong’s p = 0.01), and higher than 0.73 (0.61–0.86) of the EAT volume model (p = 0.01). In the test cohort of non-enhanced scanning (n = 100/300), the AUC of EAT-score was 0.85 (0.77–0.92), higher than that of the CT attenuation model (p < 0.001). The two nested models (EAT-score+volume and EAT-score+volume+clinical factors) for contrast-enhanced scan and one (EAT-score+CT attenuation) for non-enhanced scan showed similar AUCs with that of EAT-score (all p > 0.05). Conclusion: EAT-score generated by machine-learning-based radiomics achieved high performance in identifying patients with AF. Advances in knowledge: A radiomics analysis based on machine learning allows for the identification of AF on the EAT in contrast-enhanced and non-enhanced chest CT.
IL1B gene variants, but not TNF, CXCL8, IL6 and IL10, modify the course of cystic fibrosis in Polish patients.
Authors: Zakerska-Banaszak Oliwia , Gozdzik-Spychalska Joanna , Gabryel Marcin , Zuraszek Joanna , Skrzypczak-Zielinska Marzena , Slomski Ryszard , Dobrowolska Agnieszka , Piorunek Tomasz , Batura-Gabryel Halina 
Published: March 2022

Background: The main aim of this study was to evaluate whether selected polymorphic variants in genes from the inflammatory pathway can be predictors of pulmonary or digestive manifestation of cystic fibrosis, as well as of severity of lung disease. Materials and methods: Using pyrosequencing and sequencing we have genotyped 12 variants in TNF (rs361525, rs1800629), CXCL8 (rs4073, rs2227306, rs2227307, rs188378669), IL1B (rs16944, rs1143634, rs1142639, rs1143627), IL6 (rs1800795) and IL10 (rs1800896) genes in a cohort of 55 Polish patients with diagnosed cystic fibrosis and controls. In our study group, a pulmonary manifestation of disease revealed 44 of subjects (80%), and digestive symptoms dominated in 11 (20%) of analyzed individuals. Severe lung dysfunction has occurred in 20 (36.4%) of patients. Results: We proved, that two promoter variants of IL1B, rs1143627 (c.-118G > A) and rs16944 (c.-598T > C) are presented significantly more often in patients with severe character of lung disease compared to mild (82.5% vs. 62.8%, p-value 0.030, and 87.5% vs. 64.3%, p-value 0.008, respectively) in cystic fibrosis course. Haplotype AC formed by both changes had also a higher frequency (80%) in patients with severe course compared to the mild character (61.4%) of disease. However, the frequency of promoter variant TNF c.-308C > T (rs1800629) was presented at a significantly lower level in the patient’s group compared to healthy controls (2.7% vs. 15%, p-value 0.001). Furthermore, the presence of methicillin-resistant Staphylococcus aureus significantly correlated with the lower FEV1% in patients (p-value 0.01). Conclusions: Genetic variants, rs1143627 and rs16944, of IL1B are promising candidates as predictors of the severe character of lung disease in Polish patients with cystic fibrosis.
Dataset for the adapted COVID stress scales (ACSS) including teaching anxiety and preparedness, and resilience of academic professionals in Mexico
Authors: Padilla-Rivas Gerardo  R. , Delgado-Gallegos Juan Luis , Arellanos-Soto Daniel , Franco-Villareal Hector , Cosío-León María de los Ángeles , Avilés-Rodríguez Gener , Zuñiga-Violante Erika , Romo-Cardenas Gerardo Salvador , Islas Jose Francisco 
Published: March 2022

Because of COVID-19, many social interactions have been continued through electronic means. This has been especially true for the educational experience, where professors and students have strived to move to the virtual classroom. The data sets presented here examined how academic professionals have dealt with the stress of the move, how they have strived to become more prepared and eventually more resilient to this change. Using an online platform, we obtained data at the end of the academic period during November and December 2020. The data analyzed three major areas: teaching anxiety and preparedness, resilience, and overall stress, by applying a modified version of the adapted COVID-Stress Scales. We statistically analyzed our data looking for important correlations, to help better understand the challenges educators have met though the pandemic, and how this can assist policy-makers in managing stress and looking for ways to enhance resilience in academic professionals.
The relationship between parents' oral hygiene knowledge and children with Down Syndrome's oral hygiene via OHI-S
Authors: Sosiawan Agung , Wahjuningrum Dian Agustin , Setyowati Dini , Suhartono Michelle , Audrey Natasha Winona , Mawantari Tata Prasantat , Setiawan Fery , Pawar Ajinkya M. 
Published: March 2022

Background: Down Syndrome (DS) is a genetic disorder responsible for mental and development retardation. DS occurs when a person has an extra chromosome (47 instead of 46), the third copy of the Trisomy 21 chromosome. This causes structural and functional anomalies in the human body and some degree of intellectual disability. Children with DS have poor oral hygiene as they are unable to understand and are unaware of its importance. Oral hygiene problems commonly found in children with DS are gingivitis, periodontal problems, pain, infection, and problems with the masticatory system. This study explored the relationship between parents' knowledge and maintenance of the oral hygiene of children with DS through the OHI-S (Oral Hygiene Index Simplified) Index Score. Method: This study was conducted by distributing 25 questions via Google Form to 100 subjects that belong to POTADS (Down Syndrome Parents Association. The participants were children diagnosed with Down Syndrome and their parents. Questionnaires were used to assess parents' knowledge about their child's oral hygiene. To assess the children’s oral hygiene, dental exams were performed with the OHI-S on six tooth surfaces. To calculate the OHI-S score for each individual, the debris and calculus scores from the 6 surfaces of the teeth were totalled and divided by six. Results: The relationship between parents' knowledge and the maintenance of oral hygiene of children with DS was found by conducting a linear regression analysis and hypothetical test. The equation of Y = 77.734 + (-7.377) X was achieved through linear regression analysis, and indicated that a 1% increase in parents' knowledge caused a reduction in OHI-S score to 7.377. The hypothetical test showed that parents' knowledge affected their children's OHI-S score significantly. Conclusion: There was a significant contradictive relationship between parents' knowledge and the maintenance of oral hygiene of children with DS.
Shareholder Short-Termism, Corporate Control and Voluntary Disclosure
Authors: Jia Xue , Menon Rahul 
Published: March 2022

This paper examines how a manager uses voluntary disclosure to influence corporate control by a short-term shareholder. Because a short-term shareholder intervenes excessively, the manager’s disclosure strategy is determined by the trade-off between excessive and insufficient intervention. In equilibrium, when shareholder short-termism is not too high, the manager discloses both good and bad news and withholds intermediate news. Alternatively, when shareholder short-termism is high, the manager only discloses good news and withholds bad news. In both equilibria, withholding information is value-enhancing for the nondisclosing firms. We also show that the likelihood of disclosure weakly decreases as the shareholder is more short-term-oriented. Moreover, nondisclosing firms are more likely to face shareholder intervention than disclosing firms. This paper was accepted by Brian Bushee, accounting. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4357 .
Monolithic GaAs/Si V-groove depletion-type optical phase shifters integrated in a 300  mm Si photonics platform
Authors: Kim Younghyun , Yudistira Didit , Kunert Bernardette , Baryshnikova Marina , Alcotte Reynald , Ozdemir Cenk Ibrahim , Kim Sanghyeon , Lardenois Sebastien , Verheyen Peter , Van Campenhout Joris , Pantouvaki Marianna 
Published: March 2022

We demonstrate monolithically integrated n-GaAs/p-Si depletion-type optical phase shifters fabricated on a 300 mm wafer-scale Si photonics platform. We measured the phase shifter performance using Mach–Zehnder modulators with the GaAs/Si optical phase shifters in both arms. A modulation efficiency of

V
π

L

as low as 0.3 V·cm has been achieved, which is much lower compared to a carrier-depletion type Si optical phase shifter with pn junction. While propagation loss is relatively high at

∼
6.5

dB
/
mm

, the modulator length can be reduced by the factor of

∼
4.2

for the same optical modulation amplitude of a Si reference Mach–Zehnder modulator, owing to the high modulation efficiency of the shifters.
Genomic heterogeneity underlies multidrug resistance in Pseudomonas aeruginosa: A population-level analysis beyond susceptibility testing
Authors: Rojas Laura J. , Yasmin Mohamad , Benjamino Jacquelynn , Marshall Steven M. , DeRonde Kailynn J. , Krishnan Nikhil P. , Perez Federico , Colin Andrew A. , Cardenas Monica , Martinez Octavio , Pérez-Cardona Armando , Rhoads Daniel D. , Jacobs Michael R. , LiPuma John J. , Konstan Michael W. , Vila Alejandro J. , Smania Andrea , Mack Andrew R. , Scott Jacob G. , Adams Mark D. , Abbo Lilian M. , Bonomo Robert A. 
Published: March 2022

Background
Pseudomonas aeruginosa is a persistent and difficult-to-treat pathogen in many patients, especially those with Cystic Fibrosis (CF). Herein, we describe a longitudinal analysis of a series of multidrug resistant (MDR) P. aeruginosa isolates recovered in a 17-month period, from a young female CF patient who underwent double lung transplantation. Our goal was to understand the genetic basis of the observed resistance phenotypes, establish the genomic population diversity, and define the nature of sequence evolution over time.

Methods
Twenty-two sequential P. aeruginosa isolates were obtained within a 17-month period, before and after a double-lung transplant. At the end of the study period, antimicrobial susceptibility testing, whole genome sequencing (WGS), phylogenetic analyses and RNAseq were performed in order to understand the genetic basis of the observed resistance phenotypes, establish the genomic population diversity, and define the nature of sequence changes over time.

Results
The majority of isolates were resistant to almost all tested antibiotics. A phylogenetic reconstruction revealed 3 major clades representing a genotypically and phenotypically heterogeneous population. The pattern of mutation accumulation and variation of gene expression suggested that a group of closely related strains was present in the patient prior to transplantation and continued to change throughout the course of treatment. A trend toward accumulation of mutations over time was observed. Different mutations in the DNA mismatch repair gene mutL consistent with a hypermutator phenotype were observed in two clades. RNAseq performed on 12 representative isolates revealed substantial differences in the expression of genes associated with antibiotic resistance and virulence traits.

Conclusions
The overwhelming current practice in the clinical laboratories setting relies on obtaining a pure culture and reporting the antibiogram from a few isolated colonies to inform therapy decisions. Our analyses revealed significant underlying genomic heterogeneity and unpredictable evolutionary patterns that were independent of prior antibiotic treatment, highlighting the need for comprehensive sampling and population-level analysis when gathering microbiological data in the context of CF P. aeruginosa chronic infection. Our findings challenge the applicability of antimicrobial stewardship programs based on single-isolate resistance profiles for the selection of antibiotic regimens in chronic infections such as CF.
Associations between exclusive breastfeeding duration and children’s developmental outcomes: Evidence from Siaya county, Kenya
Authors: Onyango Silas , Kimani-Murage Elizabeth , Kitsao-Wekulo Patricia , Langat Nelson K. , Okelo Kenneth , Obong’o Christopher , Utzinger Jürg , Fink Günther 
Published: March 2022

BackgroundExclusive breastfeeding (EBF) during the first 6 months of life is widely promoted as a key strategy to enhance child health, growth, and development. Even though a high proportion of children in Kenya are currently breastfed exclusively, there is little evidence regarding the developmental benefits during the first year of life. This paper aims to fill this gap by establishing an association between EBF and early childhood developmental outcomes among children below the age of 6 months in Kenya.MethodsWe used data collected as part of a cluster-randomized controlled trial conducted in Bondo sub-county in the western part of Kenya to assess the associations between EBF and development in the first year of life. The primary exposure variable was EBF, and the outcome variable was child development as measured by the Ages and Stages Questionnaire–Third Edition (ASQ-3).ResultsWe analyzed data from 570 children aged below 6 months at the time of the interview. Breastfeeding children exclusively between 3 and 6 months was associated with 0.61 standard deviation (SD) higher ASQ-3 scores in the adjusted model. When specific domains were considered, in the adjusted models, EBF in the 3–6 months period was associated with 0.44 SD, 0.34 SD and 0.36 SD higher ASQ-3 scores in communication, gross motor, and problem solving domains, respectively. There were weak associations in the fine motor and social-emotional domains.ConclusionEBF in the 3- to 6-month age range has significant positive associations with child development, especially for communication, gross motor, and problem-solving. Programs encouraging mothers to continue EBF in this period may have substantial benefits for children.