bluuebunny/crossref_metadata_2025_split huggingface dataset:
DAMPAK COVID-19 TERHADAP ABNORMAL RETURN DAN VOLUME PERDAGANGAN SAHAM
Authors: Suryadi Elvina Cahya , Feranita Nungky Viana 
Published: January 2022

The COVID-19 pandemic is a non-natural disaster that has a huge impact around the world. This research is a quantitative research with event study method. The purpose of this research is to test the capital market reaction by looking at abnormal returns and trading volume activity before and after the COVID-19 non-natural disaster. The event day in this study was April 13rd, 2020 when the Presidential Decree was issued regarding the designation of COVID-19 as a national disaster. Using purposive sampling method, the sample of this study were 27 companies engaged in the hotel, restaurant, and tourism sub-sectors listed on the Indonesia Stock Exchange. The event period is 11 days, namely 5 days before the event, 1 day at the time of the event and 5 days after the event. Data analysis using t-test and wilxocon signed ranks test. The results of this study are: 1) there is no abnormal return during the event period, 2) there is no difference in the average abnormal return before and after the COVID-19 non-natural disaster event, 3) there is no difference in the average trading volume activity before and after the COVID-19 non-natural disaster event and after the COVID-19 non-natural disaster event.
Keywords: Event Study, Abnormal Return, Trading Volume Activity, COVID-19.
Serum 25-Hydroxyvitamin D and the risk of breast cancer in women from Southern Morocco: A case-control study
Authors: Moukal Abdellah , El Farouqi Abdallah , Aghrouch Mohamed , Chadli Smail , Zekhnini Abderrahmane , Izaabel El Hassan 
Published: January 2022

OBJECTIVES: Assessing Vitamin-D status and checking if low serum 25(OH)D is a factor in breast cancer (BC) for Southern Moroccan women. MATERIALS/METHODS: Study conducted in Morocco about women with BC ( n = 90) and controls ( n = 90). 25-hydroxy-vitamin-D biological analyzes executed during the first consultation. Social data and anthropometric parameters were collected for all participants. RESULTS: Women from urban areas constitued 67.78 % for the cases and 85.6% for the controls. The average age was 48.72±9.71 (cases) and 46.40±12.52 (controls). We found that 53.33% of cases and 40% of controls were postmenopausal and that hypovitaminosis-D affected 80 and 64.4% of cases and controls, respectively. Statistical analysis showed that hypovitaminosis-D was a significative risk factor for BC in Southern Moroccan women. The Odds Ratio was of 5 ( p < 0.0001). The BC subtypes had Odds Ratios greater than 1. The highest value was obtained with Luminal B subtype (Odds ratio = 6.25; p = 0.0007). CONCLUSION: This study reinforces the evidence implicating hypovitaminosis-D among modifiable risk factors for BC. Further studies are needed to assess the extent of hypovitaminosis-D in Moroccan women with BC.
Implementation of Traditional Medicine Remedies During The COVID-19 Pandemic as Health Improvement and Empowerment of Indonesian Women
Authors: Pradana Dhigna Luthfiyani Citra 
Published: January 2022

The COVID-19 pandemic is still a polemic of life in the world. WHO explains that there are still several countries showing an increase in COVID-19 incident.There are still active case of COVID-19 in Indonesia, which is why Indonesian people should remain vigilant, follow the instruction of the Indonesian Ministry of Health, and do 5M. In addition, the Ministry of Health in Indonesia also recommends using traditional medicine to maintain health, provide adequate nutrition and help overcome health problems. Muslim women groups from various regions in Indonesia can be suitable subjects of community service to assist the government in overcoming the COVID-19 pandemic, one of which is through education about COVID-19 and traditional medicine used during the COVID-19 pandemic. The method used in this community service is through educational webinars and measurement of understanding using an electronic questionnaire. After the educational webinar, the team collected the participant's activity in implementing traditional medicine during the COVID-19 pandemic. The results of this community service activity increased the knowledge of the community service participants to 85.83%. The participants also implemented traditional medicine by sending photos of the activities of the community service participants. This community service activity aims to overcome the problem of information gaps and increase the knowledge of Muslim women groups from various regions in Indonesia to improve and maintain the quality of life and health during the COVID-19 pandemic. Participants in this activity look active and enthusiastic during community service activities.
A Rare Case Report on Distal Spinal Muscular Atrophy (SMA)
Authors: Rahaman Habibur , Islam Md Rafiqul , Hannan MA , Jannat Maftahul 
Published: January 2022

Spinal muscular atrophies (SMA) are heterogeneous group of motor system disorders of alpha motor neuron clinically characterized by progressive lower motor neuron features. The distal form of SMA is an extremely rare disorder, which usually presents in the young adults and has a relatively slow progression with almost normal life-span. Differential diagnosis of this syndrome includes hereditary motor sensory neuropathy- Charcot-Marie-Tooth disease (CMT) and distal myopathies, which should be excluded before confirming this rare entity. As distal form of SMA is a very extremely rare condition so we would like to present a young male with this disorder and a short discussion of the theoretical aspects.
Bangladesh Journal of Neuroscience 2016; Vol. 32 (2): 106-110
Role of occupational therapy in improving quality of life of physically challenged persons
Authors: Rahman Md Shahidur 
Published: January 2022

Occupational therapy is a branch of medicine which uses different methods to help physically and mentally ill people to develop, maintain, and recover skills needed to function in day to day life, as well as in workplace environments. Thus lives of millions of disabled all over the world are enhanced to a meaningful quality of life. Occupational therapists also focus much of their work on identifying and eliminating environmental barriers to independence and participation in daily activities. This is a client-centered practice that places emphasis on the progress towards the client’s goals. The interventions are made on adapting the environment, modifying the task, teaching the skill, and educating the client/family in order to increase participation in and performance of daily activities, particularly those that are meaningful to the client. They often find it challenging to implement client-centered and occupation-based assessment tools into practice. This part of rehabilitation medicine is neglected in our country. More work is needed to understand how best practices can be incorporated into a changing occupational therapy daily practice. The aim of this review article is to highlight the importance of occupational therapy and its application in improving the quality of life and quality adjusted life years in physically challenged persons.
Bangladesh Journal of Neuroscience 2017; Vol. 33 (1): 34-38
Role of Calcitonin Gene Related Peptide (CGRP) in Migraine
Authors: Ali Md Ashraf , Rahaman Habibur 
Published: January 2022

Migraine is the second most primary headache. The prevalence of Migraine is 12% in the general population, including 18% in women and 6% in men. Migraine can start in childhood and adolescence and continue throughout lifespan. It is most prevalent among people in their 30s and 40s. Migraine is a debilitating hemicranial headache that is pulsating, aggravated by movement, nausea, vomiting and having sensitivity to light and sound, with or without aura. It can affect all aspects of life as work and school, parenting and family relationships and personal and leisure time. There are some theory regarding pathogenesis of migraine which includes cortical spreading depression, cortical spreading oligemia, activation of trigeminocervical complex leading to neuroinflammation & release of vasodialating neuropeptides which include calcitonin gene related peptide (CGRP), substance P, vasoactive intestinal polypeptide (VIP), nitric oxide (NO), and pituitary adenylate cyclase activating peptide (PACAP) & genetic factor. CGRP is a potent vasodilator and causes perivascular plasma protein extravasation and nociceptive pain. Newer medications target CGRP both for acute and preventive treatment of migraine.
Bangladesh Journal of Neuroscience 2017; Vol. 33 (1): 39-43
A Case of Paroxysmal Kinesigenic Dystonia : Epilepsy Mimic
Authors: Uddin Mohammad Najim , Rahaman Habibur , Habib Ahsan , Rizvi Abu Nasir , Bhuiyan Md Moniruzzaman , Islam Md Rafiqul 
Published: January 2022

Background: We report a rare case of movement disorder Paroxysmal kinesigenic dystonia who was misdiagnosed as Epilepsy and Conversion disorder.
Case report: A 35 -year female presented with episodic painful twisting of her Right hand and arm only when she is awake. These events were triggered by sudden movements and would last several seconds to minutes. Her symptoms were unilateral and her physical and neurological examinations were normal. Treatment with anticonvulsants Oxcarbazepine improved her symptoms.
Conclusion: Although an uncommon movement disorder, it is important to recognize the clinical presentation of Paroxysmal kinesigenic dystonia as most patients respond very well to medical treatment.
Bangladesh Journal of Neuroscience 2017; Vol. 33 (1): 44-46
Association between Chlamydia Pneumonia Seropositivity and Ischemic Stroke: A Case-Control Study
Authors: Uddin Mohammad Nur , Dey SubashKanti , Ahmed Anis , Islam Md Rafiqul , Jahan Munira , Rauf Dolan Mohammad Abdur , Hassan Shahadat , Md Rakunuzzaman - , Rashid Mohammad Bazlur 
Published: January 2022

Background: Apart from traditional risk factors, infectious agent might contribute to ischemic stroke. The aim of this study was to evaluate the association between Chlamydia pneumonia seropositivity and ischemic stroke.
Methods: 42 ischemic stroke patients diagnosed by history, clinical examination and confirmed by CT scan or MRI of brain selected as case. The same number (42) of age and sex matched subjects having no history or clinical evidence of ischemic stroke were selected as control. Blood samples were collected within 2 to 14 days of ischemic stroke from indoor patients. Controls were collected from both indoor and outdoor patients with neurological disorders other than ischemic stroke. Anti-C. pneumoniae antibodies IgG and IgA were detected by ELISA (enzyme-linked immunosorbent assay) in the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU).
Results: Among the study population, 66.7% of cases and 45.2 % of control patients were seropositive to C. Pneumoniae IgG (OR: 2.42, 95% CI: 1.00 - 5.85, p = 0.048). Whereas IgA were positive in 81% of case and 57.1% of control (OR: 3.19, 95% CI: 1.19 - 8.52, p = 0.018). Seropositivity to IgA showed more significant results than IgG.
Conclusion: There was a significant association between Chlamydia pneumonia seropositivity both IgG and IgA with ischemic stroke.
Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 47-54
Association of Serum Uric Acid level in Patients with Alzheimer’s Disease
Authors: Ahtesam Mohammad Saifullah , Habib Md Ahsan , Islam Md Rafiqul , Khan Md Rezaul Karim , Rahman Hasan Zahidur , Rizvi Abu Nasir , Bhuiyan Md Moniruzzaman , Barman Kanuj Kumar , Showkat Syeeda , Islam Md Monirul , Md Raknuzzaman - , Islam Md Fakrul , Sarker Imran , Hannan MA 
Published: January 2022

Background: Alzheimer’s disease is the most common cause of dementia. Uric acid is the end product of purine metabolism in humans and acts as a natural antioxidant, accounting up to 60% of the free radical scavenging activity in human blood to prevent free radicals induced oxidative cell injury. This study aimed to explore the association between serum uric acid level and cognitive impairment of Alzheimer’s disease patients compared to those of the non-demented age and sex matched controls.
Methods: This case control study was carried out in the department of neurology, BSMMU, Dhaka. Total 116 patients were enrolled as study population after satisfying inclusion and exclusion criteria. Among them, 58 were grouped as case and rest 58 were control. All blood samples for serum uric acid were measured in the Biochemistry lab, Department of Biochemistry, BSMMU, Dhaka.
Results: A signiûcant reduction of serum uric acid levels in the AD group was found compared to those of the control group (4.35±1.59 Vs 6.89±1.68) which was statistically significant (p<0.001). We also found a positive correlation between serum uric acid levels with severity of Alzheimer’s disease (rp = 0.633, P<0.001). Among demographic variables educational qualification was statistically significant (p=0.006) in AD patients.
Conclusion: This study showed that oxidative injuries have an important role in the pathogenesis of AD. Higher levels of uric acid are associated with a decreased risk of dementia and better cognitive function later in life.
Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 83-88
SPRC Suppresses Experimental Periodontitis by Modulating Th17/Treg Imbalance
Authors: Peng Qian , Zhao Bingkun , Lin Jie , Liu Haixia , Zhou Rong , Lan Dongmei , Yao Chao , Cong Shaohua , Tao Shen , Zhu Yizhun , Wang Raorao , Qi Shengcai 
Published: January 2022

Object: The aims of the study were to explore the protective effects of S-propargyl-cysteine (SPRC) on periodontitis and to determine the underlying mechanisms.Methods: A rat periodontitis model was constructed by injecting LPS and SPRC (0, 25, and 50 mg/kg/d) was administered intraperitoneally. H2S and CSE level were detected. The alveolar bone level was evaluated by micro-CT, HE staining and methylene blue staining analysis. Inflammation-related factors, Treg and Th17 cells were detected by immunohistochemistry, RT-PCR, immunofluorescence, Western blot and flow cytometry. Phosphorylation levels of ERK1/2 and CREB were analysed.Results: The administration of SPRC significantly increased the expression of CSE in the gingival tissue and the concentration of endogenous H2S in the peripheral blood. Simultaneously, SPRC significantly inhibited the resorption of alveolar bone based on the H&amp;E staining, micro-CT and methylene blue staining analysis. Compared with the periodontitis group, the levels of IL-17A, IL-10 were downregulated and IL-6,TGF-β1 were upregulated in the SPRC groups. In the SPRC group, the percentage of TH17 cells and the expression of ROR-γt were downregulated, while the percentage of Tregs and the expression of Foxp3 were upregulated accompanied with inhibition of phosphorylation ERK1/2 and CREB.Conclusion: SPRC can prevent the progression of periodontitis by regulating the Th17/Treg balance by inhibition of the ERK/CREB signalling pathway.
Light-Triggered Adhesive Silk-Based Film for Effective Photodynamic Antibacterial Therapy and Rapid Hemostasis
Authors: Huang Tingting , Zhou Zhihao , Li Qiaoyuan , Tang Xiaoxuan , Chen Xiaoli , Ge Yifan , Ling Jue 
Published: January 2022

Successful control of massive hemorrhage in deep wounds with irregular shape and low elasticity still remains great challenges in the clinic. As the wound sites are usually at risk of bacterial infection, it is necessary to design an ideal hemostatic agent with rapid hemostasis and excellent antibacterial activity. In this study, we developed a light responsive hemostatic film for effective handling of liver bleeding with promising photodynamic therapy against S. aureus onnear infrared (NIR) irradiation. Based on silk fibroin, the film exhibited desirable biocompatibility and mechanical property as a hemostat tape. Significantly, the film tape achieved excellent tissue adhesion and hemostasis in vivo within 2 min of UV exposure, which would have a great potential as a multifunctional biomedical material in the field of tissue repair such as wound healing, bone repair, and nerve regeneration.
The Crosstalk Between Malignant Cells and Tumor-Promoting Immune Cells Relevant to Immunotherapy in Pancreatic Ductal Adenocarcinoma
Authors: Liu Xuefei , Luo Ziwei , Ren Xuechen , Chen Zhihang , Bao Xiaoqiong , Zheng Jianghua , Zuo Zhixiang 
Published: January 2022

Background: Pancreatic ductal adenocarcinoma (PDAC) is dominated by an immunosuppressive microenvironment, which makes immune checkpoint blockade (ICB) often non-responsive. Understanding the mechanisms by which PDAC forms an immunosuppressive microenvironment is important for the development of new effective immunotherapy strategies.Methods: This study comprehensively evaluated the cell-cell communications between malignant cells and immune cells by integrative analyses of single-cell RNA sequencing data and bulk RNA sequencing data of PDAC. A Malignant-Immune cell crosstalk (MIT) score was constructed to predict survival and therapy response in PDAC patients. Immunological characteristics, enriched pathways, and mutations were evaluated in high- and low MIT groups.Results: We found that PDAC had high level of immune cell infiltrations, mainly were tumor-promoting immune cells. Frequent communication between malignant cells and tumor-promoting immune cells were observed. 15 ligand-receptor pairs between malignant cells and tumor-promoting immune cells were identified. We selected genes highly expressed on malignant cells to construct a Malignant-Immune Crosstalk (MIT) score. MIT score was positively correlated with tumor-promoting immune infiltrations. PDAC patients with high MIT score usually had a worse response to immune checkpoint blockade (ICB) immunotherapy.Conclusion: The ligand-receptor pairs identified in this study may provide potential targets for the development of new immunotherapy strategy. MIT score was established to measure tumor-promoting immunocyte infiltration. It can serve as a prognostic indicator for long-term survival of PDAC, and a predictor to ICB immunotherapy response.
RETRACTED: Prevalence, Predictors, and Clinical Presentation of Acute Pericardial Effusion Following Percutaneous Coronary Intervention
Authors: Zhao Bei , Zhang Jie , Li Yun , Feng Xueyao , Mao Shuai , Yin Zhao , Liu Li , Song Dapeng , Wang Shouli 
Published: January 2022

Background: Iatrogenic pericardial effusion (PE) has been demonstrated to lead to cardiac injury as a sign of systemic inflammatory response.Objectives: This study sought to determine the anatomical characteristics and clinical presentation associated with PE after percutaneous coronary intervention (PCI) by using echocardiography.Methods: The clinical outcomes of all patients with coronary artery disease who underwent PCI from July 2014 to December 2018 were evaluated. The quantitative and qualitative analyses of PE were performed. The associations between the presence of PE and procedural factors were also evaluated.Results: A total of 882 patients were enrolled. PE was found in 144 patients (16.3%) and was mostly located in the anterior pericardium at low amounts. The serum levels of high-sensitive C-reaction protein before PCI and troponin T in the group with PE after PCI were significantly higher than those in the group without PE (p &lt; 0.0001). The presence of PE was associated with the procedural time (OR = 1.02, p = 0.035) and the degree of interventional complexity (multiple vessels OR = 1.89, p = 0.014; chronic total occlusion OR = 2.04, p = 0.005; and PCI with rotational atherectomy OR = 1.15, p = 0.011) independent of the number of culprit vessels and stents. During 1-year follow-up, a significantly higher number of cardiac deaths (3) and myocardial infarctions (8) occurred in patients with PE than in patients without PE (P &lt; 0.05).Conclusion: Post-PCI acute PE was frequent, generally mild, mainly asymptomatic, and independently associated with procedural time and complexity. This effusion, which is considered as a cardiac damage marker, could be a predominant clinical sign for long-term prognosis.
Helicobacter pylori Infection Acts as an Independent Risk Factor for Intracranial Atherosclerosis in Women Less Than 60 Years Old
Authors: Guo Yinjie , Xu Canxia , Zhang Linfang , Chen Zhiheng , Xia Xiujuan 
Published: January 2022

Background: Studies show inconsistent results regarding the relationship between Helicobacter pylori (H. pylori) infection and stroke. The present study assessed a potential association between H. pylori infection and an important risk factor for stroke, intracranial atherosclerosis.Methods: In total, 15,798 subjects with transcranial Doppler (TCD) and 13C-urea breath test (13C-UBT) were enrolled from March 2012 to March 2017. Intracranial atherosclerosis was further measured using intracranial carotid artery calcification (ICAC) on past or recent head CT, and 14,084 subjects were ultimately included in the study. Baseline demographics, atherosclerosis risk factors, and laboratory results were investigated. Since endothelial dysfunction is critical to the development of atherosclerosis, the role of H. pylori in migration, tube formation, and proliferation of human brain microvascular endothelial cells (HBMECs) was assessed in vitro.Results: The intracranial atherosclerosis group had a higher proportion of women and a greater rate of H. pylori infection than those without intracranial atherosclerosis. H. pylori infection was significantly more common in women with intracranial atherosclerosis than males. In addition, the incidence of intracranial atherosclerosis was significantly higher in women with H. pylori infection than uninfected women (53.8 vs. 46.4%, p &lt; 0.001). In an adjusted model, H. pylori was shown to be an independent risk factor for intracranial atherosclerosis in women ≤ 60 years of age [odds ratio (OR) = 2.261, 95% CI = 1.839–2.780, p &lt; 0.001]. Serum exosomes from patients with H. pylori infection had significantly reduced brain endothelial cell migration, tube formation, and proliferation in vitro.Conclusion:Helicobacter pylori infection may be an important independent risk factor for intracranial atherosclerosis in women ≤ 60 years of age.
The 4.2 ka Event and the End of the Maltese “Temple Period”
Authors: Groucutt Huw S. , Carleton W. Christopher , Fenech Katrin , Gauci Ritienne , Grima Reuben , Scerri Eleanor M. L. , Stewart Mathew , Vella Nicholas C. 
Published: January 2022

The small size and relatively challenging environmental conditions of the semi-isolated Maltese archipelago mean that the area offers an important case study of societal change and human-environment interactions. Following an initial phase of Neolithic settlement, the “Temple Period” in Malta began ∼5.8 thousand years ago (ka), and came to a seemingly abrupt end ∼4.3 ka, and was followed by Bronze Age societies with radically different material culture. Various ideas concerning the reasons for the end of the Temple Period have been expressed. These range from climate change, to invasion, to social conflict resulting from the development of a powerful “priesthood.” Here, we explore the idea that the end of the Temple Period relates to the 4.2 ka event. The 4.2 ka event has been linked with several examples of significant societal change around the Mediterranean, such as the end of the Old Kingdom in Egypt, yet its character and relevance have been debated. The Maltese example offers a fascinating case study for understanding issues such as chronological uncertainty, disentangling cause and effect when several different processes are involved, and the role of abrupt environmental change in impacting human societies. Ultimately, it is suggested that the 4.2 ka event may have played a role in the end of the Temple Period, but that other factors seemingly played a large, and possibly predominant, role. As well as our chronological modelling indicating the decline of Temple Period society in the centuries before the 4.2 ka event, we highlight the possible significance of other factors such as a plague epidemic.