bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Phase II Trial of Abiraterone With Dutasteride for Second‐Generation Antiandrogen‐ and Chemotherapy‐Naïve Patients With Castration‐Resistant Prostate Cancer
Authors: Shiota Masaki , Inoue Ryo , Tashiro Kojiro , Kobayashi Keita , Horiyama Shizuyo , Kanji Hiromi , Eto Masatoshi , Egawa Shin , Haginaka Jun , Matsuyama Hideyasu 
Published: December 2022

AbstractThe development of a novel therapy to overcome primary and acquired resistance to abiraterone is an unmet need. This study aimed to evaluate the efficacy and safety of adding 5α‐reductase inhibitor dutasteride to abiraterone, explore proof of concept, and identify candidates suitable for combination therapy. This phase II, single‐arm, and open‐label study enrolled second‐generation antiandrogen‐ and chemotherapy‐naïve patients with castration‐resistant prostate cancer. Patients received abiraterone and prednisolone for 4 weeks, followed by adding dutasteride. The primary end point was a 50% prostate‐specific antigen response rate. Serum concentrations of abiraterone and its metabolites as well as HSD3B1 and SRD5A2 genotypes were measured. The association between drug metabolism and genotypes and their impact on the efficacy of combination therapy were assessed. Among 21 patients, 18 (85.7%) achieved ≥50% PSA reduction. Median time to treatment failure was not reached during the median follow‐up of 15.4 months. No patients experienced grade ≥3 adverse events. Although dutasteride reduced serum 3‐keto‐5α‐abiraterone concentrations, higher serum 3‐keto‐5α‐abiraterone concentrations on combination therapy were associated with a shorter time to treatment failure. HSD3B1 and SRD5A2 genotypes were associated with serum Δ4‐abiraterone and 3‐keto‐5α‐abiraterone concentrations before adding dutasteride, respectively. Time to treatment failure was longer in patients with homozygous wild‐type HSD3B1, but comparable between those with the SRD5A2 genotype. The promising outcomes of this study warrant further investigation of combination therapy in a randomized trial. Stratification by HSD3B1 and SRD5A2 genetic profiles might identify patients suitable for combination therapy.
A simple screening method for distillation sequence of thermally coupled dividing wall column: distillation sequence morphological analysis method (DSMAM)
Authors: Li Wenyan , Cheng Xiaomin , Li Zhongyang , Fang Zhiqiang , Li Hao , Fang Jing 
Published: December 2022

AbstractBACKGROUNDDistillation is a separation process with a high energy consumption. Therefore, energy‐saving optimizations of the distillation process have become particularly significant. However, developing methods to quickly choose the best energy‐saving distillation sequence for the separation of multiple components has become a key problem.RESULTSIn this paper, the Distillation Sequence Morphometry Analysis Method (DSMAM) was established to quickly screen energy‐saving and efficient distillation sequences and was integrated with a Dividing‐wall column (DWC) device, which has more industrial significance. Meanwhile, an evaluation and screening index η of separated multicomponent energy‐saving distillation sequences was proposed. Finally, based on the DSMAM, and combined with Microsoft Visual Basic 6.0 (VB) and Aspen Plus V11 (Aspen) software, a set of distillation sequence screening and evaluation programs of four‐component separation systems was generated. The distillation column sequence with high thermodynamic efficiency and the energy‐saving coupling structure of distillation were obtained quickly and accurately.CONCLUSIONThis program was applied to the separation of the n‐butane‐benzene‐n‐heptane‐n‐nonane system. It was able to quickly obtain the first three energy‐saving distillation sequences without thermal coupling and the first three energy‐saving distillation sequences in the search space. The direct‐thermal coupling distillation sequence of the energy‐saving fluid was integrated and coupled, providing a preliminary design reference for industrial design and application. © 2022 Society of Chemical Industry (SCI).
Are service crops an alternative for mitigating N2O emissions in soybean crops in the Argentinian Pampas?
Authors: Petrasek Marcos René , Piñeiro Gervasio , Bonvecchi Virginia Enriqueta , Yahdjian Laura 
Published: December 2022

AbstractService crops (or cover crops) play an important role in simplified agricultural systems. Service crops reduce agricultural external inputs and increase ecosystem services but their ability to mitigate nitrous oxide (N2O) emissions is still uncertain. The main objective of this study was to evaluate N2O emissions in soybean–soybean (Glycine max [L.] Merr) rotations that included different service crops. Treatments included continuous soybean with winter fallow and soybean with three service crops: oat (Avena sativa L.), vetch (Vicia villosa Roth.), and a mixture of oat and vetch in a randomized complete block design. Service crops were sown 2 months after soybean harvest and were terminated 2 months before soybean planting. Nitrous oxide emissions were determined during the fourth year of the field experiment. We found that service crops did not significantly affect overall mean N2O emission rates, with mean emission rates from the fallow, oat, vetch, and oat‐vetch treatments of 1.82 ± 0.35, 1.95 ± 0.34, 2.71 ± 0.43, and 2.42 ± 0.42 kg N2O‐N ha−1 per year, respectively. Service crops with low C/N ratios (vetch and oat‐vetch mixtures) significantly increased N2O emissions in spring, after their termination. Overall, soil inorganic N content (NO3− or NH4+) was the main driver that explained the N2O emissions from different treatments, whereas water‐filled pore space controlled the temporal variability of emissions. Our results suggest that service crops with a very short growing season may increase soil N availability for cash crops, but do not reduce N2O emissions due to long periods of high N availability without crops.
Ni‐Ferrite an efficient catalyst for synthesis of 3‐aryl substituted isoxazole‐5‐carboxylic acids via one‐pot multicomponent reaction
Authors: Totre Ganesh , Shinde Dnyaneshwar , Patil Prakash , Kulkarni Pramod 
Published: December 2022

AbstractHere, we have reported an efficient one‐pot, three‐component reaction between various aryl aldehydes, NH2OH.HCl, and propargyl alcohol using Ni‐Fe2O4 as a nanocatalyst. Reactions were performed in ethanol at room temperature to obtain various 3‐aryl substituted isoxazole‐5‐carboxylic acids. The advantage of this protocol is that it formed isoxazole derivatives with free carboxylic acid functionality in one pot, which could transform into various other functional groups. This approach has several merits, including a quick reaction time, a wide range of substrates, excellent product yields, and reusable catalysts.
Particle Tracing Based on 4D Flow Magnetic Resonance Imaging: A Systematic Review into Methods, Applications, and Current Developments
Authors: Roos Paul R. , Rijnberg Friso M. , Westenberg Jos J. M. , Lamb Hildo J. 
Published: December 2022

BackgroundParticle tracing based on 4D Flow MRI has been applied as a quantitative and qualitative postprocessing technique to study temporally evolving blood flow patterns.PurposeTo systematically review the various methods to perform 4D Flow MRI‐based particle tracing, as well as the clinical value, clinical applications, and current developments of the technique.Study typeThe study type is systematic review.SubjectsPatients with cardiovascular disease (such as Marfan, Fontan, Tetralogy of Fallot), healthy controls, and cardiovascular phantoms that received 4D Flow MRI with particle tracing.Field Strength/SequenceThree‐dimensional three‐directional cine phase‐contrast MRI, at 1.5 T and 3 T.AssessmentTwo systematic searches were performed on the PubMed database using Boolean operators and the relevant key terms covering 4D Flow MRI and particle tracing. One systematic search was focused on particle tracing methods, whereas the other on applications. Additional articles from other sources were sought out and included after a similar inspection. Particle tracing methods, clinical applications, clinical value, and current developments were extracted.Statistical TestsThe main results of the included studies are summarized, without additional statistical analysis.ResultsOf 127 unique articles retrieved from the initial search, 56 were included (28 for methods and 54 for applications). Most articles that described particle tracing methods used an adaptive timestep, a fourth order Runge–Kutta integration method, and linear interpolation in the time dimension. Particle tracing was applied in heart chambers, aorta, venae cavae, Fontan circulation, pulmonary arteries, abdominal vasculature, peripheral arteries, carotid arteries, and cerebral vasculature. Applications were grouped as intravascular, intracardiac, flow stasis, and research.Data ConclusionsParticle tracing based on 4D Flow MRI gives unique insight into blood flow in several cardiovascular diseases, but the quality depends heavily on the MRI data quality. Further studies are required to evaluate the clinical value of the technique for different cardiovascular diseases.Evidence Level5.Technical EfficacyStage 1.
Analysis of mutational history of multidrug‐resistant genotypes with a mutagenetic tree model
Authors: Pirkl Martin , Büch Joachim , Devaux Carole , Böhm Michael , Sönnerborg Anders , Incardona Francesca , Abecasis Ana , Vandamme Anne‐Mieke , Zazzi Maurizio , Kaiser Rolf , Lengauer Thomas , The EuResist Network Study Group  
Published: December 2022

AbstractHuman immunodeficiency virus (HIV) can develop resistance to all antiretroviral drugs. Multidrug resistance, however, is a rare event in modern HIV treatment, but can be life‐threatening, particular in patients with very long therapy histories and in areas with limited access to novel drugs. To understand the evolution of multidrug resistance, we analyzed the EuResist database to uncover the accumulation of mutations over time. We hypothesize that the accumulation of resistance mutations is not acquired simultaneously and randomly across viral genotypes but rather tends to follow a predetermined order. The knowledge of this order might help to elucidate potential mechanisms of multidrug resistance. Our evolutionary model shows an almost monotonic increase of resistance with each acquired mutation, including less well‐known nucleoside reverse transcriptase (RT) inhibitor‐related mutations like K223Q, L228H, and Q242H. Mutations within the integrase (IN) (T97A, E138A/K G140S, Q148H, N155H) indicate high probability of multidrug resistance. Hence, these IN mutations also tend to be observed together with mutations in the protease (PR) and RT. We followed up with an analysis of the mutation‐specific error rates of our model given the data. We identified several mutations with unusual rates (PR: M41L, L33F, IN: G140S). This could imply the existence of previously unknown virus variants in the viral quasispecies. In conclusion, our bioinformatics model supports the analysis and understanding of multidrug resistance.
Strong, Chemically Stable, and Enzymatically On‐Demand Detachable Hydrogel Adhesion Using Protein Crosslink
Authors: Lee Wonseok , Heo Eunseok , Koo Hye Been , Cho In , Chang Jae‐Byum 
Published: December 2022

AbstractAchieving strong adhesion between hydrogels and diverse materials is greatly significant for emerging technologies yet remains challenging. Existing methods using non‐covalent bonds have limited pH and ion stability, while those using covalent bonds typically lack on‐demand detachment capability, limiting their applications. In this study, a general strategy of covalent bond‐based and detachable adhesion by incorporating amine‐rich proteins in various hydrogels and inducing the interfacial crosslinking of the hydrogels using a protein‐crosslinking agent is demonstrated. The protein crosslink offers topological adhesion and can reach a strong adhesion energy of ≈750 J m−2. The chemistry of the adhesion is characterized and that the inclusion of proteins inside the hydrogels does not alter the hydrogels’ properties is shown. The adhesion remains intact after treating the adhered hydrogels with various pH solutions and ions, even at an elevated temperature. The detachment is triggered by treating proteinase solution at the bonding front, causing the digestion of proteins, thus breaking up the interfacial crosslink network. In addition, that this approach can be used to adhere hydrogels to diverse dry surfaces, including glass, elastomers and plastics, is shown. The stable chemistry of protein crosslinks opens the door for various applications in a wide range of chemical environments.
A case of postpsychotic depression improved by switching antipsychotic monotherapy
Authors: Oguchi Yoshiyo , Nakagawa Atsuo , Kocha Hiroki 
Published: December 2022

AbstractAimPostpsychotic depression is challenging to differentiate, yet it is clinically frequent, puts patients at risk for suicide, and affects their mental capacity. Treatment with antipsychotics for postpsychotic depression is desirable; however, there is no consensus on which antipsychotics are optimal.Case presentationWe report the case of a young male patient with schizophrenia in his 20s who developed postpsychotic depression, including despair, overwhelming loss, humiliation, and suicidal ideation during treatment with paliperidone. As a result, we switched his medication to lurasidone, which relieved his depressive symptoms without any symptom relapse and his social functioning improved.ConclusionPostpsychotic depression has more psychic characteristics than behavioral. According to various international guidelines for the pharmacological treatment of schizophrenia, antipsychotics should be administered for depressive symptoms of schizophrenia. As evidenced in this case report, lurasidone may be a practical alternative for improving postpsychotic depression.
A minimax algorithm based on Newton's method and an application for finding multiple solutions of p‐area problems
Authors: Patra Suchismita , Kumar V. V. K. Srinivas 
Published: December 2022

AbstractIn this paper, we present a numerical scheme which is an improved minimax method proposed by Yao‐Zhou's study along with Newton's method for finding the multiple solutions of p‐area problems. It is combined with Newton's method since the local minimax method stagnates close to a critical point of the functional whereas Newton's method converges rapidly close to a critical point. We discuss the theoretical convergence result of this proposed hybrid scheme and the convergence of the finite element based solutions as well. Further, we carry out instability analysis of the unstable solutions through their local minimax type characterizations, where the instability behavior of a solution can be analyzed before calculating the solution. This analysis also provides ways to numerically compute the Morse index of the solutions. Finally, numerical experiments are performed to demonstrate the algorithm and the theoretical results.
Harmonica consensus, controversies, and future directions in radiotherapy for pediatric Wilms tumors
Authors: McAleer Mary Frances , Melchior Patrick , Parkes Jeannette , Pater Luke , Rübe Christian , Saunders Daniel , Paulino Arnold C. , Janssens Geert O. , Kalapurakal John 
Published: December 2022

AbstractRadiotherapy (RT) is essential for multimodality treatment of pediatric renal tumors, particularly in higher‐risk and metastatic disease. Despite decades of use, particularly for Wilms tumor, there remain controversies regarding RT indications, timing, dose, and targets. To align global management, we address these issues in this international HARMONIsation and CollAboration (HARMONICA) project. There are multiple knowledge gaps and opportunities for future research including: (1) utilization of advanced RT technologies, including intensity‐modulated RT, proton beam therapy, combined with image‐guided RT to reduce target volumes; (2) impact of molecular biomarkers including loss of heterozygosity at 1p, 16q, and 1q gain on RT indications; (3) mitigation of reproductive toxicity following RT; (4) promotion of RT late effects research; and (5) support to overcome challenges in RT utilization in low‐ and middle‐income countries where 90% of the world's children reside. Here, we outline current status and future directions for RT in pediatric renal tumors.
Scoping review of rational polytherapy in patients with drug‐resistant epilepsy
Authors: Grinalds McKenzie S. , Yoder Caleb , Krauss Zach , Chen Aleda M. , Rhoney Denise H. 
Published: December 2022

AbstractThere is a paucity of literature regarding the optimal selection of combination antiseizure medications (ASMs) for drug‐resistant epilepsy (DRE). The aim of this scoping review is to evaluate current evidence related to “rational polytherapy” among adults with DRE. Using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses for Scoping Reviews (PRISMA‐SCr) guidelines, PubMed, ProQuest, CINAHL, and Cochrane databases were searched using DRE‐ and polytherapy‐related keywords. The exclusion criteria applied included: non‐English; non‐human studies; non‐research studies; participants less than 18 years; status epilepticus; ASM monotherapy; and certain ASMs. In Covidence, two researchers independently reviewed articles for inclusion at each phase, with a third resolving conflicts. Data were extracted, with quality appraisal using the Mixed Methods Appraisal Tool (MMAT). Of the 6477 studies imported for screening, 33 studies were included. Clinical, humanistic, and economic outcomes were reported by 26, 12, and one study, respectively. Common efficacy‐related clinical outcomes included ≥50% reduction in seizure frequency (n = 14), seizure freedom (n = 14), and percent reduction in seizure frequency (n = 8). Common humanistic outcomes included quality of life (n = 4), medication adherence (n = 2), sleep‐related outcomes (n = 2), and physician and patient global assessments (n = 2). The economic study reported quality‐adjusted life years. The median MMAT score was 80 (range: 60–100). Two studies referenced the standard definition of DRE, whereas five studies did not specifically define DRE. Gaps in the literature include limited generalizability, minimal reports in pregnancy, and lack of optimal ASM combinations, among others. Strengths of the evidence include addressing a variety of outcomes. Inconsistent definitions of DRE, small sample sizes, and heterogeneity among studies limit the ability to draw meaningful conclusions. Optimal combinations of ASMs for rational polytherapy for DRE is unclear.
Systematic and evaluative review of school climate instruments for students, teachers, and parents
Authors: Gonzálvez Carolina , Bacon Victoria , Kearney Christopher A. 
Published: December 2022

AbstractThis study involved a systematic and evaluative review of school climate measures to catalog main domains and subdomains and rate parameters of instrument presentation and psychometric quality. Four databases were used (Web of Science, Scopus, ERIC, and PsycINFO) and 37 instruments (studies) met inclusion criteria (instrument measured school climate; psychometric properties of the instrument were provided; every instrument included in the review has its original version published; the article was in English or Spanish; the article was a peer‐reviewed publication). Information was synthesized according to instrument presentation and psychometric quality. The expansion of literature search routes was designed to mitigate publication bias. Analysis revealed four main domains among extant school climate measures: relationships (social relationships, school connectedness, leadership, and culture), environment (school facilities, physical comfort, and cleanliness), safety/discipline (school safety, fairness of rules, bullying and aggression, disciplinary harshness, and general drug use), and academic (academic outcomes, equality of opportunity, engagement, and cohesiveness/competitiveness). This domain/subdomain architecture could serve as a touchstone for conceptualizing school climate and developing and refining future assessment devices for this construct. The domain/subdomain architecture could also help guide school reform efforts. Limitations included possible publication bias and an exclusive focus on questionnaires and not other methods to assess school climate.
Linking intervention experiences to child outcomes in a school‐based social skills training program
Authors: Ho Leslie C. , Bierman Karen L. , Jacobson Linda N. , Welsh Janet A. , Hall Cristin M. , Lee David L. 
Published: December 2022

AbstractSmall group social skills training (SST) is recommended to improve the social behavior and peer relations of rejected children, but child responses vary. This study explored variation in intervention experiences that emerged in a large study of a school‐based SST program for peer‐rejected children and associations with program outcomes. One hundred and seven peer‐rejected elementary students (60% White, 15% Black, 22% Latinx, 3% Multi‐racial, and 65% male) were identified by classroom sociometrics and randomly assigned to a year‐long small group SST program. Normative classmates served as partners. Among the peer‐rejected targets of the intervention, those with relatively better pretreatment social skills received more SST sessions and were more positively engaged, whereas those with fewer social skills and more behavior problems experienced more negative peer responses during SST sessions and less collateral support from teachers and parents. Hierarchical regressions (controlling for pretreatment scores) revealed attenuated intervention benefits for children who received more negative peer responses during SST and less parent and teacher support. The findings suggest that, within a sample of peer‐rejected children, those with more severe skill deficits and elevated behavior problems at pretreatment have lower‐quality SST experiences that reduce intervention benefits, even when normative classmates serve as peer partners. These issues warrant careful attention in future SST intervention design and research.
Unpacking the social‐emotional health of education support professionals during the COVID‐19 pandemic
Authors: Naples Lauren H. , Cipriano Christina , Eveleigh Abigail , Stoffers Melissa , Barnes Tia N. 
Published: December 2022

AbstractThis study sought to understand education support professionals' (ESPs) experiences early in the COVID‐19 pandemic, including how they were feeling about their roles in education, strategies they were using to cope with unprecedented times, barriers they encountered toward maintaining SE health at work, and opportunities they identified as critical for creating safe and supportive school environments. This study employed a convergent parallel (QUAN + QUAL) mixed methods research design to capture ESPs' affective experiences and use of social and emotional learning (SEL). Data were collected in partnership with the National Education Association across 4 weeks through a survey including open and closed‐ended questions. A total of 175 participants responded to the quantitative portion of the survey and at least one qualitative survey question. Findings suggest ESPs were feeling frustrated and experiencing very little SEL support in their daily work. ESPs would benefit from increased communication, inclusion, recognition, and well‐being promotion in their schools. This study offers new insight into how schools and districts can provide better SEL support to ESPs.