bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food trade among Pacific Island countries and territories: implications for food security and nutrition
Authors: Thow Anne Marie , Ravuvu Amerita , Ofa Siope Vakataki , Andrew Neil , Reeve Erica , Tutuo Jillian , Brewer Tom 
Published: December 2022

Abstract
Background
There is growing attention to intra-regional trade in food. However, the relationship between such trade and food and nutrition is understudied. In this paper, we present an analysis of intra-regional food trade in the Pacific region, where there are major concerns regarding the nutritional implications of international food trade. Using a new regional database, we examine trends in food trade among Pacific Island Counties and Territories (PICTs) relative to extra-regional trade.

Results
Intra-regional trade represents a small, but increasing proportion of total imports. The major food group traded within the Pacific is cereal grains and flour, which represented 51% of total intra-regional food trade in 2018. Processed and prepared foods, sweetened or flavoured beverages, processed fish, and sugar and confectionary are also traded in large quantities among PICTs. Trade in root crops is negligible, and overall intra-regional trade of healthy foods is limited, both in terms of tonnage and relative to imports from outside the region. Fiji remains the main source of intra-regional imports into PICTs, particularly for non-traditional staple foods.

Conclusions
This study highlights the growth in trade of staple foods intra-regionally, indicating a role for Fiji (in particular) in regional food security. Within this overall pattern, there is considerable opportunity to enhance intra-regional trade in traditional staple foods, namely root crops. Looking forward, the current food system disruption arising from the COVID-19 pandemic and associated policy measures has highlighted the long-term lack of investment in agriculture, and suggests an increased role for regional approaches in fostering trade in healthy foods.
Expectation modulates the preferential processing of task-irrelevant fear in the attentional blink: evidence from event-related potentials
Authors: Sun Meng , Shang Chenyang , Jia Xi , Liu Fang , Cui Lixia , Wei Ping , Zhang Qin 
Published: December 2022

Abstract
Background
Reporting the second of the two targets is impaired when it occurs 200–500 ms after the first, the phenomenon in the study of consciousness is the attentional blink (AB). In the AB task, both the emotional salience and the expectation of the second target increase the likelihood of that target being consciously reported. Yet, little is known about how expectations modulate the prioritized processing of affective stimuli. We examined the role of expecting fearful expression when processing fear in an AB task. Participants were presented with an AB task where the 2nd target (T2) is either a fearful face or a neutral face, and had to report the target's gender. The frequency of fearful to neutral faces on a given block was manipulated, such that participants could either expect more or less fearful faces.

Results
In the Experiment 1, we found that fearful faces were more likely to be recognized than neutral faces during the blink period (lag3) when participants were not expecting a fearful face (low fear-expectation); however, high fear-expectation increased the discrimination of fearful T2 than neutral T2 outside the blink period (lag8). In the Experiment 2, we assessed ERP brain activity in response to perceived T2 during the blink period. The results revealed that fearful faces elicited larger P300 amplitudes compared to neutral faces, but only in the low fear-expectation condition, suggesting that expecting a fearful expression can suppress the processing of task-irrelevant facial expression and unexpected fearful expression can break through this suppression. Fearful T2 elicited larger vertex positive potential (VPP) amplitudes than neutral T2, and this affective effect was independent of fear-expectation. Since no effect of expectation was found on the VPP amplitude while P300 exhibited significant interaction between expectation and expression, this suggests that expectations modulate emotional processing at a later stage, after the fearful face has been differentially processed.

Conclusions
These results provided clear evidence for the contribution of the expectation to the prioritized processing of second affective stimuli in the AB.
The relationship between the degeneration and asymmetry of the lumbar multifidus and erector spinae muscles in patients with lumbar disc herniation with and without root compression
Authors: Yazici Alikemal , Yerlikaya Tuba 
Published: December 2022

Abstract
Background
The determination of muscle pathologies in lumbar disc herniation (LDH) and other conditions with low back pain is important for understanding low back problems and determining appropriate treatment methods. In patients with lumbar disc herniation with radiculopathy, elucidating the effect of root compression on the severity of muscle degeneration may predict the importance of alleviating root compression. For this purpose, magnetic resonance imaging (MRI) was used to compare the degeneration and asymmetries of the lumbar musculus multifidus (MF) and lumbar musculus erector spinae (ES) muscles in patients with lumbar discopathy without root compression (radiculopathy) and in patients with lumbar discopathy with root compression (radiculopathy).

Methods
The patients were examined in two groups: 56 patients with lumbar discopathy and no radiculopathy (Non-rad group) and 51 patients with lumbar discopathy and radiculopathy (Rad group). On axial MRI sections passing through the centre of the disc at the L3-S1 level, the asymmetry, cross-sectional area (CSA), fat infiltration, and total CSA (TCSA = MF + ES) of the MF and ES muscles were measured and compared.

Results
No difference was seen between the groups with respect to the CSA values of the right and left MF and left ES, but a significant difference was found in the right ES CSA (p = 0.021). The CSA and TCSA of the MF and ES showed no asymmetry according to group. Severe fat infiltration of > 50% in the right and left MF and left ES was found in the Rad group at a higher rate than in the Non-rad group. Fat infiltration was significantly positively correlated with age, body mass index, and the duration of pain (p < 0.001, p < 0.001, p = 0.004, respectively).

Conclusions
The study results showed a correlation between LDH and paraspinal muscle degeneration, while no correlation was found with asymmetry. Severe (> 50%) fat infiltration is associated with root compression, and the severity of fat filtration increases in the presence of root compression. The development of more severe degeneration due to denervation associated with root compression plays a role in the emergence of this situation. Therefore, in patients with lumbar disc herniation with radiculopathy, it can be foreseen that to stop and correct severe fat infiltration and muscle degeneration, first, nerve root compression should be corrected with appropriate medical treatment methods, and in patients in whom there is no response, the pressure should be alleviated with appropriate surgical methods.
Phase 2 study of AV-GBM-1 (a tumor-initiating cell targeted dendritic cell vaccine) in newly diagnosed Glioblastoma patients: safety and efficacy assessment
Authors: Bota Daniela A. , Taylor Thomas H. , Piccioni David E. , Duma Christopher M. , LaRocca Renato V. , Kesari Santosh , Carrillo Jose A. , Abedi Mehrdad , Aiken Robert D. , Hsu Frank P. K. , Kong Xiao-Tang , Hsieh Candace , Bota Peter G. , Nistor Gabriel I. , Keirstead Hans S. , Dillman Robert O. 
Published: December 2022

Abstract
Background
Vaccine immunotherapy may improve survival in Glioblastoma (GBM). A multicenter phase II trial was designed to determine: (1) the success rate of manufacturing the Aivita GBM vaccine (AV-GBM-1), (2) Adverse Events (AE) associated with AV-GBM-1 administration, and (3) survival.

Methods
Fresh suspected glioblastoma tissue was collected during surgery, and patients with pathology-confirmed GBM enrolled before starting concurrent Radiation Therapy and Temozolomide (RT/TMZ) with Intent to Treat (ITT) after recovery from RT/TMZ. AV-GBM-1 was made by incubating autologous dendritic cells with a lysate of irradiated autologous Tumor-Initiating Cells (TICs). Eligible patients were adults (18 to 70 years old) with a Karnofsky Performance Score (KPS) of 70 or greater, a successful TIC culture, and sufficient monocytes collected. A cryopreserved AV-GBM-1 dose was thawed and admixed with 500 μg of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) before every subcutaneous (s.c.) administration.

Results
Success rates were 97% for both TIC production and monocyte collection. AV-GBM-1 was manufactured for 63/63 patients; 60 enrolled per ITT; 57 started AV-GBM-1. The most common AEs attributed to AV-GBM-1 were local injection site reactions (16%) and flu-like symptoms (10%). Treatment-emergent AEs included seizures (33%), headache (37%), and focal neurologic symptoms (28%). One patient discontinued AV-GBM-1 because of seizures. Median Progression-Free Survival (mPFS) and median Overall Survival (mOS) from ITT enrollment were 10.4 and 16.0 months, respectively. 2-year Overall Survival (OS) is 27%.

Conclusions
AV-GBM-1 was reliably manufactured. Treatment was well-tolerated, but there were numerous treatment-emergent central nervous system AEs. mPFS was longer than historical benchmarks, though no mOS improvement was noted.

Trial registration
NCT, NCT03400917, Registered 10 January 2018,
The effect of Mediterranean diet on nutritional status, muscle mass and strength, and inflammatory factors in patients with colorectal cancer-induced cachexia: study protocol for a randomized clinical trial
Authors: Bagheri Amir , Babaei Mohammad , Rezaei Saied , Motallebnejad Zoya Asl , Ganjalikhani Maryam , Malekahmadi Mahsa , Esmaillzadeh Ahmad 
Published: December 2022

Abstract
Background
Current dietary strategies to manage cancer cachexia and the relevant outcomes did not provide a comprehensive solution. This study will evaluate the effect of a Mediterranean diet on inflammatory markers, nutritional status, muscle mass, and strength among patients with cancer cachexia (CC).

Methods
This will be a randomized clinical trial involving men and women diagnosed with localized or advanced colorectal cancer-induced cachexia. In total, 40 patients with CC will be recruited based on inclusion criteria and then these patients will be randomly allocated to receive either a Mediterranean diet (n = 20) or only routine nutritional advice (n = 20) for 8 weeks. The primary outcome will be nutritional status, muscle mass and strength, and serum concentrations of inflammatory markers including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and high-sensitive C-reactive protein (hs-CRP). Moreover, we will consider serum albumin and total protein levels, complete blood count (CBC), and quality of life as the secondary outcomes. All outcomes will be measured at the beginning and end (the eighth week) of the study. We will assess participants’ adherence to the prescribed diets by using a 1-day food record in the second, fourth, sixth, and eighth weeks of the study.

Discussion
Along with adequate calorie and protein intake in cancer cachexia, reducing inflammatory cytokines might be a useful strategy for maintaining nutritional status and body composition. Mediterranean diet has been shown to have anti-inflammatory properties, and by its components, it might help patients with cachexia to have a better nutritional status and quality of life.

Trial registration
Iranian Registry of Clinical Trials (www.irct.ir) RCT20211027052884N1. Prospectively registered on November 09, 2021.
Bio-loggers inserted in intravaginal sponges, or subcutaneously, as tools to measure body temperature
Authors: Abecia José-Alfonso , Luis Silvia , Canto Francisco , Palacios Carlos 
Published: December 2022

AbstractThe body temperature of animals can be measured by thermistors, thermocouples, or radiotelemetry devices that are implanted surgically under the skin, although the suitability of subcutaneous temperature as an indicator of core temperature can be limited because of abnormal temperature readings, probably affected by ambient temperature and animal inactivity. This study compared the use of bio-loggers designed to monitor subcutaneous temperature (Tsub), with their use embedded in intravaginal sponges to measure vaginal temperature (Tvag). Three ewes were implanted with a subcutaneous temperature bio-logger that was configured to record Tsub every 30 min for a month. Ewes were given an intravaginal sponge for 12 days two days later. Inside the sponges were installed programmed bio-loggers that measured Tvag every 5 min. The ambient temperature (Tamb) and relative humidity were monitored using mini data-loggers. Mean Tsub was lower (P < 0.001) during the day (38.02 ± 0.02 °C) than at night (38.10 ± 0.02 °C), with maximum Tsub (38.57 °C) at 20:00 h and minimum temperature (37.36 °C) at 08:00 h; however, mean Tvag was higher (P < 0.001) during the day (38.71 ± 0.01 °C) than at night (38.62 ± 0.01 °C), with maximum Tsub (39.02 °C) at 20:55 h and minimum temperature (38.33 °C) occurred at 08:25 h. Mean Tsub (38.08 ± 0.02 °C) was lower (P < 0.0001) than was Tvag (38.65 ± 0.10 °C) in the daytime and at night (P < 0.001). Both temperatures had a 24-h rhythm (P < 0.0001), but differed (P < 0.001) in the mean midline estimating statistic of rhythm (MESOR) (Tvag: 38.67 ± 0.02 °C, Tsub: 38.09 ± 0.02 °C), amplitude (Tvag: 0.21° ± 0.01C; Tsub: 0.25 ± 0.01 °C), and acrophase (Tvag: 18:27 ± 0.38 h, Tsub: 20:48 ± 0.44 h). The coefficient of correlation between the two temperatures, measured simultaneously for 12 d was 0.644 (P < 0.01), and between Tamb and the two physiological temperatures, measured at the same time throughout the 12 d experiment, was 0.319 (P < 0.01) for Tsub and 0.287 (P < 0.01) for Tvag. The linear regression analysis of the 24 h circadian rhythm in Tsub and Tvag indicated a high coefficient of determination with Tvag (0.9255) and a lower coefficient of determination with Tsub (0.4292). In conclusion, the integration of a mini body temperature logger into a vaginal sponge, or their subcutaneous insertion, provided a continuous and accurate record of body temperature. Furthermore, the strong correlation between mean 24 h circadian Tvag and Tamb, demonstrated the usefulness of Tvag in biometeorological studies in sheep. As an alternative to employing these devices subcutaneously, they can also can be utilized as a biomarker of core body temperature inserted in vaginal sponges.
Risk of depression, anxiety, and stress among the Saudi general population during the COVID-19 pandemic
Authors: Alsaif Bandar , Algahtani Fahad D. , Alzain Mohamed Ali , Zrieq Rafat , Aldhmadi Badr K. , Alnasser Badr , Hassan Sehar-un-Nisa 
Published: December 2022

Abstract
Background
Promoting mental health and wellness is crucial for healthy communities. This study aims to assess the vulnerability of experiencing psychological reactions such as depression, anxiety, and stress within the general population in Saudi Arabia during the COVID-19 pandemic.

Methods
A cross-sectional online survey was completed by 754 participants recruited from thirteen regions of Saudi Arabia. The information on background variables was obtained by using a set of close-ended questions. The DASS-21, a screening tool was used to assess the risk of depression, anxiety, and stress. Pie-chart displayed the levels of risk to experience psychological reactions. The Chi-square test and Adjusted Odd Ratios (AOR) reported the risk factors associated with experiencing psychological reactions in the study population.

Results
The vulnerability to mild to extremely severe levels of stress, anxiety and depression were (36.5%), (34.9%), and (43.5%), respectively. Findings demonstrated that females were at higher risk to experience anxiety (AOR = 1.56; 95% CI 1.11–2.18) and stress (AOR = 1.48; 95% CI 1.10–2.10) as compared to males. Unmarried individuals had higher vulnerability for anxiety (AOR = 1.60; 95% CI 1.04–2.44) and depression (AOR = 1.55; 95% CI 1.02–2.37) as compared to married individuals. Those who lost their job during the pandemic had a higher risk to experience anxiety (AOR = 2.02; 95% CI 1.10–3.74) and depression (AOR = 2.01: 95% CI 1.09–3.87) as compared to those who remain employed. Diagnosis with COVID-19 was associated with anxiety (AOR = 2.40; 95% CI 1.27–4.52) and stress (AOR = 2. 0; 95% CI 1.10–3.69). Participants with chronic medical conditions were almost twice at risk to experience stress (AOR = 2.0; 95% CI 1.38–2.87) depression (AOR = 2.14; 95% CI 1.53–2.99) and anxiety (AOR = 2.59; 95% CI 1.78–3.78) as compared to those without such conditions.

Conclusions
Findings imply the allocation of adequate psychological resources to prevent long-term psychological repercussions in at-risk populations such as females, unmarried individuals, those who lost their jobs, diagnosed with COVID-19 and those with chronic medical conditions.
Validation study of the Functional Assessment of Cancer Therapy-Cognitive Function-Version 3 for the Portuguese population
Authors: Oliveira Ana F. , Santos Isabel M. , Fernandes Sofia , Bem-Haja Pedro , Torres Ana 
Published: December 2022

Abstract
Background
Cancer-related cognitive impairment is a common and potentially debilitating symptom experienced by patients with non-central nervous system (CNS) cancers, with negative impact on their quality of life. The Functional Assessment of Cancer Therapy-Cognitive Function-Version 3 (FACT-Cog-v3) is the most extensively used instrument specifically developed to evaluate cognitive complaints in adult cancer patients. Nevertheless, this self-report measure is not yet validated for the Portuguese population. Therefore, the purpose of this study was to evaluate the psychometric properties of the FACT-Cog-v3 among patients with non-CNS cancers in Portugal.

Methods
The validation study was conducted based on a convenience sample of 281 patients with non-CNS cancers, aged between 18 and 65 years, recruited online. A confirmatory factor analysis (CFA) was used to test the factor structure of the Portuguese FACT-Cog-v3 version; internal consistency analysis was also conducted. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30–version 3) and the Hospital Anxiety and Depression Scale (HADS) were also used to test the concurrent, convergent, and discriminant validity of the scale.

Results
CFA supported a four-factor model with good fix indexes and internal consistencies: perceived cognitive impairments (α = 0.97), comments from others (α = 0.92), perceived cognitive abilities (α = 0.93), and impact on quality of life (α = 0.92). Concurrent, convergent, and discriminant validities were confirmed. Moderate and strong correlations were found between the FACT-Cog-v3 subscales and the QLQ-C30 cognitive functioning subscale. Good convergent validity, with moderate correlations, was found between the FACT-Cog-v3 subscales and the HADS-A, HADS-D, and QLQ-C30 fatigue, sleep disturbance, and global health status subscales. Acceptable discriminant validity, with weak and moderate correlations, was demonstrated between the FACT-Cog-v3 subscales and the QLQ-C30 pain and nausea/vomiting subscales.

Conclusions
The Portuguese FACT-Cog-v3 version can be considered a reliable and valid measure to assess cognitive concerns of patients with non-CNS cancers, with relevance for research and clinical practice.
Antifungal activity assessment of nanocomposites of natural chitosan and gelatin with a mahogany plant extract for conservation of historical textiles
Authors: Ahmed Harby E. , Marouf Sherif , Mohamed Wael S. 
Published: December 2022

Abstract
Fungi and bacteria are important causes of damage to historical textiles. Many methods are used to resist innate damage in historical textiles. The study aim was to use an innovative method that loaded a mahogany plant extract onto natural chitosan and gelatin nanocomposite polymers to prepare chitosan / mahogany plant extract composite and gelatin mahogany plant extract nanocomposite and evaluate their potential for protecting historical textiles from biological damage. The fungi and bacteria found on historical textile samples were identified by biochemical methods. We performed an antifungal activity assessment of the mahogany—natural chitosan and mahogany—gelatin polymers to study the effect of these materials on the mechanical, chemical, and optical properties of dyed linen textiles. New linen fabrics dyed with madder, turmeric, and pomegranate were mordanted with alum, copper, and iron mordants. These materials were applied to dyed linen fabrics, and then the treated linen was artificially aged. The mechanical, chemical, and optical characteristics of the dyed linen fabric were examined by scanning electron microscopy, Fourier-transform infrared spectroscopy, CIELab, the tensile strength and elongation test, and the air permeability test. Mahogany – chitosan was more effective than mahogany – gelatin as an antifungal and antibacterial treatment of dyed linen and caused fewer changes in the mechanical, chemical, and optical characteristics. The mahogany – chitosan composite is recommended for preservation of historical linen textiles.
A short novel antimicrobial peptide BP100-W with antimicrobial, antibiofilm and anti-inflammatory activities designed by replacement with tryptophan
Authors: Ajish Chelladurai , Kumar S. Dinesh , Kim Eun Young , Yang Sungtae , Shin Song Yub 
Published: December 2022

AbstractBP100 is a short cationic antimicrobial peptide (AMP) designed using a combinatorial chemistry approach based on the cecropin A-melittin hybrid. It displays potent antimicrobial activity against gram-negative bacteria and low toxicity toward eukaryotic cells. To develop a short AMP with potent cell selectivity, antibiofilm and anti-inflammatory activities, we designed a newly BP100 analog, BP100-W, in which Leu-3 at the hydrophobic face of BP100 was replaced by Trp. BP100-W possessed better cell selectivity, with a 1.7-fold higher therapeutic index than BP100. BP100-W displayed more effective synergistic activity when combined with several antibiotics, such as chloramphenicol, ciprofloxacin and oxacillin, compared to BP-100. BP100-W also exhibited stronger antibiofilm activity than BP100 in inhibiting biofilm formation by multidrug-resistant Pseudomonas aeruginosa (MDRPA) and eradicating the preformed biofilms of MDRPA. Moreover, unlike BP100, BP100-W significantly suppressed the production and expression of lipopolysaccharide (LPS)-induced pro-inflammatory cytokines, such as the tumor necrosis factor-α and nitric oxide. Boron-dipyrromethene-TR-cadaverine displacement assay demonstrated that the inhibitory activity of BP100-W on LPS-induced inflammation in RAW 264.7 cells may be due to increased direct interaction with LPS. Our results suggest that BP100-W exhibits potential for future use as an antimicrobial, antibiofilm and anti-inflammatory agent.