bluuebunny/crossref_metadata_2025_split huggingface dataset:
Buoyancy Effect on Leading Edge Cooling of a Rotating Turbine Blade
Authors: Tansakul Pipat , Thawornsathit Phongsakorn , Juntasaro Varangrat , Juntasaro Ekachai 
Published: June 2022

Abstract
A numerical study is performed to investigate the effect of buoyancy on the cooling performance of leading edge cooling of a rotating turbine blade under the real operating condition at baseload. The Double swirl cooling (DSC) configuration is simulated using the shear stress transport (SST) k-ω turbulence model that proves to be the most accurate for impinging flow under rotating condition due to its lowest averaged second norm. The numerical results reveal that the DSC cooling performance is deteriorated by buoyancy because the total average Nusselt number and the thermal performance factor of DSC with buoyancy effect are significantly lower than those of DSC without buoyancy effect. This points out that the buoyancy effect is a very important parameter to be concerned in the numerical study of leading edge cooling of a rotating turbine blade due to its great influence on the cooling performance and heat transfer distribution.
Sjögren’s syndrome as a cause of both lymphoid interstitial pneumonia and light chain deposition disease in a single patient
Authors: Steward Matthew , Yu Johannes H , Gibbons Michael A 
Published: June 2022

A man in his 70s presents with 12 months of progressive dyspnoea, sicca symptoms and Raynaud’s phenomenon. Serological testing and tear duct biopsy confirm Sjögren’s syndrome (SS). Bilateral nodular-cystic appearances highly suggestive of lymphoid interstitial pneumonia (LIP) are noted on high-resolution computed tomography (HRCT), supported by a 40% lymphocytosis on bronchoalveolar lavage.Biopsy of a non-characteristic additional pulmonary nodule diagnoses light chain deposition disease (LCDD). Extrapulmonary organ involvement is excluded. Pulmonary function tests are well-preserved, and the patient is kept under active surveillance without requiring immunomodulatory treatment.LIP and LCDD both have a strong association with SS. Identification of these disease associations is crucial as they may result in multiorgan involvement or progression to haematological malignancy. This is the first case published in the literature and highlights that a pragmatic approach to investigations can avoid unnecessary procedures, and that treatment may be guided by symptomology.
Efficacy of contralateral acupuncture in women with migraine without aura: protocol for a randomised controlled trial
Authors: Li Qifu , Feng Jialei , Zhang Xinghe , Wang Yanan , Zhao Siwen , Xing Chonghui , Song Yongli , Zeng Xuanxiang , Kong Meng , Zheng Yunqiu , Zhao Ling , Guo Taipin 
Published: June 2022

IntroductionMigraine is a common neurological disorder with a higher prevalence occurring in women. Migraine without aura (MwoA) is the most common type of migraine. In recent years, the safety and effectiveness of acupuncture for migraines have been internationally recognised. Contralateral acupuncture (CAT) (Jùcì) is an ancient classic acupuncture technique from Huang Di Nei Jing that refers to the acupoints on the right side (healthy side) selected for diseases on the left (affected side) and vice versa. Some studies have shown that efficacy of CAT on the painful disorder is even better than ipsilateral acupuncture (IAT), but there remains a lack of high-quality evidence to support it.Methods and analysisThis is a single-centre, randomised and sham-controlled clinical trial in China with three parallel groups that aim to evaluate the efficacy of CAT in women with unilateral MwoA. 243 participants will be randomly divided into the experimental group (CAT group), control group 1 (IAT group) and control group 2 (sham acupuncture group) (1:1:1 allocation ratio). Each group will be given 30-minute treatment sessions, once every other day, approximately three times per week, for a total of 24 treatments and follow-up visits two times. The primary outcome is the changes in days of migraine attacks. The secondary outcomes are frequency of migraine attacks, intensity of migraine, migraine duration, the dose of intake of acute medication, the Migraine-Specific Quality of Life Questionnaire, the Migraine Disability Assessment Score, the Headache Impact Test-6 and the Pittsburgh Sleep Quality Index. The data will be collected at the baseline time (week 0), end of treatment (week 4–8) and the follow-up time (week 12–16). Adverse events will be collected and recorded during each treatment.Ethics and disseminationEthics approval was obtained from the Ethics Committee of the Sports Trauma Specialist Hospital of Yunnan Province (2021-01). All participants will provide written informed consent before randomisation. The results of this study will be published in a peer-reviewed journal and presented at conferences.Trial registration numberChinese Clinical Trial Registration Center (ChiCTR2100051479).
Recovering staff, recovering services: massive-online support for recovering a paediatric service using Lean and compassionate communication
Authors: Smith Iain M , Bayliss Elaine 
Published: June 2022

The COVID-19 pandemic has infected tens of millions worldwide. Healthcare systems have been stretched caring for the most seriously ill and healthcare workers have struggled to maintain non-COVID services leading to backlogs.Strategies proposed to support the recovery of backlogs include additional administration support; waiting list data validation; enhanced patient communication; and use of systematic improvement methods to make rapid incremental improvements.As part of COVID-19 recovery, a hospital trust in northern England used the Lean systematic improvement approach to recover the waiting list of a paediatric service to pre-COVID levels. The intervention strategy used a massive-open-online-course (Lean Fundamentals) to support the improvement project lead to follow a structured improvement routine to apply Lean improvement techniques.By acknowledging that staff were overburdened by the requirements of COVID-19 and that patients were stuck in a system of disconnected processes, administrative activities were redesigned around an ethos of compassionate communication that put patients first.Over a period of 8 weeks, the project reduced the waiting list from 1109 to 212. Waiting times were reduced from a maximum of 36 months to a 70-day average.Lean is often described in terms of increasing process efficiency and productivity. It is not often associated with staff benefits. However, when seen in the context of unburdening staff to deliver patient care, Lean has potential to support the recovery of both staff and services. Lean Fundamentals, with its accessible massive-online design, may provide a means of supporting such improvement at scale.
Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer
Authors: Kelenis Demetra P. , Rodarte Kathia E. , Kollipara Rahul K. , Pozo Karine , Choudhuri Shreoshi Pal , Spainhower Kyle B. , Wait Sarah J. , Stastny Victor , Oliver Trudy G. , Johnson Jane E. 
Published: June 2022

Abstract

Genomic studies support the classification of small cell lung cancer (SCLC) into subtypes based on the expression of lineage-defining transcription factors ASCL1 and NEUROD1, which together are expressed in ∼86% of SCLC. ASCL1 and NEUROD1 activate SCLC oncogene expression, drive distinct transcriptional programs, and maintain the in vitro growth and oncogenic properties of ASCL1 or NEUROD1-expressing SCLC. ASCL1 is also required for tumor formation in SCLC mouse models. A strategy to inhibit the activity of these oncogenic drivers may therefore provide both a targeted therapy for the predominant SCLC subtypes and a tool to investigate the underlying lineage plasticity of established SCLC tumors. However, there are no known agents that inhibit ASCL1 or NEUROD1 function. In this study, we identify a novel strategy to pharmacologically target ASCL1 and NEUROD1 activity in SCLC by exploiting the nuclear localization required for the function of these transcription factors. Karyopherin β1 (KPNB1) was identified as a nuclear import receptor for both ASCL1 and NEUROD1 in SCLC, and inhibition of KPNB1 led to impaired ASCL1 and NEUROD1 nuclear accumulation and transcriptional activity. Pharmacologic targeting of KPNB1 preferentially disrupted the growth of ASCL1+ and NEUROD1+ SCLC cells in vitro and suppressed ASCL1+ tumor growth in vivo, an effect mediated by a combination of impaired ASCL1 downstream target expression, cell-cycle activity, and proteostasis. These findings broaden the support for targeting nuclear transport as an anticancer therapeutic strategy and have implications for targeting lineage-transcription factors in tumors beyond SCLC.

Significance:
The identification of KPNB1 as a nuclear import receptor for lineage-defining transcription factors in SCLC reveals a viable therapeutic strategy for cancer treatment.
Distinct Transcriptional Programs in Ascitic and Solid Cancer Cells Induce Different Responses to Chemotherapy in High-Grade Serous Ovarian Cancer
Authors: Loret Nele , Vandamme Niels , De Coninck Jordy , Taminau Joachim , De Clercq Kato , Blancke Gillian , Jonckheere Sven , Goossens Steven , Lemeire Kelly , De Prijck Sofie , Verstaen Kevin , Seurinck Ruth , Van Dorpe Jo , Weyers Steven , Denys Hannelore , Van de Vijver Koen , Lambrecht Bart N. , Tummers Philippe , Saeys Yvan , Berx Geert 
Published: June 2022

Abstract

High-grade serous ovarian cancer (HGSOC) is responsible for the largest number of ovarian cancer deaths. The frequent therapy-resistant relapses necessitate a better understanding of mechanisms driving therapy resistance. Therefore, we mapped more than a hundred thousand cells of HGSOC patients in different phases of the disease, using single-cell RNA sequencing. Within patients, we compared chemonaive with chemotreated samples. As such, we were able to create a single-cell atlas of different HGSOC lesions and their treatment. This revealed a high intrapatient concordance between spatially distinct metastases. In addition, we found remarkable baseline differences in transcriptomics of ascitic and solid cancer cells, resulting in a different response to chemotherapy. Moreover, we discovered different robust subtypes of cancer-associated fibroblasts (CAF) in all patients. Besides inflammatory CAFs, vascular CAFs, and matrix CAFs, we identified a new CAF subtype that was characterized by high expression of STAR, TSPAN8, and ALDH1A1 and clearly enriched after chemotherapy. Together, tumor heterogeneity in both cancer and stromal cells contributes to therapy resistance in HGSOC and could form the basis of novel therapeutic strategies that differentiate between ascitic and solid disease.

Implications:
The newly characterized differences between ascitic and solid cancer cells before and after chemotherapy could inform novel treatment strategies for metastatic HGSOC.
Thomas Paine in French: Translations, Transfers and Circulations in the Age of Revolutions (1776–1793)
Authors: Lounissi Carine 
Published: June 2022

Abstract
This essay looks into the publishing history of three major works by Thomas Paine in French, Common Sense (1776), the Letter to the Abbe Raynal (1782) and Rights of Man (1791–92). Although it is often taken for granted that Paine’s writings circulated to a great extent in the Atlantic world, the translation of these writings in French has not been studied in depth. These translations appeared at three key moments of French, American and Atlantic history. The strategies used by the translators and those who commissioned these translations will be studied in an approach combining book history, the history of print culture, as well as political and diplomatic history. By relying on new archival material, especially manuscripts of translations and letters, I intend to offer a new insight into the translation and circulation of Paine’s writings in French and in France before and after he settled there in 1792.
Yoked by Violence: The Paxton Boys, Representation, and a “humble Petition”
Authors: Gordon Scott Paul 
Published: June 2022

Abstract
A 1764 manuscript petition, a “humble Petition” from Lancaster County, differs substantially from the published Remonstrance that has been taken to represent the views of the Paxton Boys, who murdered 20 Native Americans in Lancaster County and attempted to destroy 140 more in the Philadelphia Barracks. The Remonstrance, which began with a Whiggish demand for increased legislative representation for frontier counties, has led historians to describe the Paxton Boys as frontier democrats who marched on Philadelphia to present grievances to the provincial government. The “humble Petition,” however, has little interest in legislative representation. It resembles the Declaration that defiantly defends the murders and threatens more. The “humble Petition,” then, enables us to reposition the Remonstrance as an expression of political elites—an early entry in the pamphlet war that followed the murders—who appropriated the Lancaster County murders to adjust power in Pennsylvania by means of the 1764 elections.
Quantification of Tumor Abnormal Proteins in the Diagnosis and Postoperative Prognostic Evaluation of Gastric Cancer
Authors: Gu Chao , Xie Li , Li Bowen , Zhang Lu , Li Fengyuan , Wang Weizhi , Su Jiang , Xu Zekuan 
Published: June 2022

Background: Abnormal glycosylation of proteins has been identified in almost all types of cancers and is closely related to the cancer progression, metastasis, and survival of cancer patients. This study was to explore the values of serum tumor abnormal protein (TAP), an abnormal glycochain protein, in the diagnosis and prognosis of gastric cancer (GC). Methods: A total of 335 GC patients were included as the study group, and another 335 subjects served as the control group. Tumor abnormal protein expression was compared between the 2 groups. Correlation analysis was used to assess the correlations of TAP with clinicopathological factors. Gastric cancer patients were divided into training set and test set at a ratio of 2:1. Univariate and multivariate Cox regression analyses in training set were used to evaluate the prognostic significance of TAP in GC patients and explore the independent risk factors for overall survival (OS) and disease-free survival (DFS) to establish a prognostic model, followed by testing of the model. According to the median of TAP, 335 GC patients were divided into 2 groups to plot the survival curves of OS and DFS. Results: Tumor abnormal protein expression in the study group was significantly higher than in the control group. Taking the best cut-off value of TAP (110.128 μm2) as the diagnostic criteria for GC, the sensitivity and specificity of TAP were 83.58% and 97.61%, respectively, and the area under the receiver operating characteristics (ROC) curve was 0.935, which was not inferior to computed tomography (CT). Tumor abnormal protein expression was an independent risk factor for OS and DFS. The prognostic predictive value of TAP was better than that of pathological stage in GC patients. The model with TAP was effective in predicting prognosis. Conclusion: Tumor abnormal protein is an effective indicator for early screening and prognostic evaluation of GC and can also assist the clinical diagnosis and treatment of GC.
Nurse Migration in Australia, Germany, and the UK: A Rapid Evidence Assessment of Empirical Research Involving Migrant Nurses
Authors: Smith Jamie B , Herinek Doreen , Woodward-Kron Robyn , Ewers Michael 
Published: June 2022

Forecasts predict a growing shortage of skilled nursing staff in countries worldwide. Nurse migration is already a common strategy used to address nursing workforce needs. Germany, the UK, and Australia are reviewed here as examples of destination countries for nurse migrants. Agreements exist between countries to facilitate nurse migration; however, it is not evident how nurse migrants have contributed to data on which these arrangements are based. We examined existing primary research on nurse migration, including educational needs and initiatives to support policymakers’, stakeholders’, and health professions educators’ decisions on measures for ethical and sustainable nurse migration. We conducted a rapid evidence assessment to review available empirical research data which involved, was developed with, or considered migrant nurses to address the research question: what are the findings of research that directly involves migrant nurses in producing primary research data? A total of 56 papers were included. Four main themes were identified in this research data: Research does not clearly define what is meant by the term migrant nurses; discrimination is often reported by migrant nurses; language and communication competencies are important; and structured integration programs are highly valued by migrant nurses and destination healthcare employers. Migrant nurses continue to experience discrimination and reduced career opportunities and therefore should be included in research about them to better inform policy. Structured integration programs can improve the experience of migrant nurses by providing language support (if necessary), a country-specific bridging program and help with organisational hurdles. Not only researching migrant nurses but making them active partners in research is of great importance for successful, ethical, and sustainable migration policies. A broader evidence base, especially with regard to the views and experiences of migrant nurses and their educational support needs, should be promoted to make future immigration policy more needs-based, sustainable and ethically acceptable.
Adapting to transradial approach in cerebral angiography: Factors influencing successful cannulation
Authors: Yaser Arafath Mohamed , Bhatia Vikas , Kumar Ajay , Chauhan Rajeev , Prabhakar Anuj , Gupta SK , Singh Paramjeet 
Published: June 2022

Background To evaluate factors that influence the successful cannulation of intracranial vessels using a transradial approach. Methods A total of 61 transradial diagnostic angiograms were evaluated in a tertiary care center from July 2020 to December 2021. We evaluated the learning curve and aortic arch vessel factors that may influence the cannulation of intracranial major vessels using a transradial approach. Results Learning curve for the procedure was established after 21 cases. We were successful in cannulating the supra-aortic arteries except in 4 cases where we were unable to cannulate the left VA (vertebral artery). Significant positive correlation was seen between time to Sim (Simmons curve) formation and aortic arch diameter ( p = .002). Significant positive correlation was also seen between left VA take-off angle and time to cannulate left VA ( p = .001) and negative correlation was noted between left CCA (common carotid artery) take-off angle and time to cannulate left CCA ( p = .001). Conclusion Transradial approach is a feasible and safe approach for performing cerebral angiography. Multiple factors can influence the procedure time and successful cannulation of intracranial vessels. With the availability of radial specific hardware in the future, procedural success and time taken to complete the procedure may improve.
An evaluation of the effects of ascorbic acid on the endothelium of coronary and aorta arteries in lead-intoxicated rabbits
Authors: Vahedi Parviz , Rajabzadeh Asghar , Soleimani Ali 
Published: June 2022

Objectives: Lead exposure has destructive effects on some organs. It may produce a variety of toxic effects on endothelial cells of the vascular system. Any changes or damages to endothelial cells may lead to cardiovascular diseases, particularly the formation of atherosclerotic plaques. The aim of this study was to determine the ameliorative effects of ascorbic acid on the endothelium of coronary and aorta arteries in lead-exposed rabbits. Methods: In this study, 30 white male rabbits of New Zealand race (weighing about 1.6–2 kg and 5 months old) were used and divided randomly into three groups: Group 1 ( N = 10) that served as the control and received water and normal diet, Group 2 ( N = 10) was exposed to lead acetate 547 ppm (5 mg/L) daily for 40 days, and Group 3 ( N = 10) received vitamin C (500 mg/kg) and underwent the same duration of lead exposure (5 mg/L) daily for 40 days. The levels of cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein were measured using spectrophotometry, and the level of blood lead was calculated using a lead analyzer (Magellan Diagnostics, USA). The animals were anesthetized by pentobarbital (50 mg/kg). Subsequently, they were sacrificed, and their thoracic aortas and coronary arteries were removed. Then fixation, tissue processing, histological sectioning, and H & E staining were carried out. Finally, the sections were studied using light microscopy. The results were analyzed using the Mann–Whitney test. Results: The results indicated that ascorbic acid could reduce the destructive effects of lead on vascular endothelial cells and prevent the formation of atherosclerotic plaques in coronary and aorta arteries. Conclusion: The results of this study confirm the beneficial effects of ascorbic acid against the destructive effects of lead on vascular endothelial cells. Hence, it could be proposed as a potential prophylactic treatment for the amelioration of lead toxicity, prevention of atherosclerosis, and improvement of endothelial cells dysfunction.
RAE1 is a prognostic biomarker and is correlated with clinicopathological characteristics of patients with hepatocellular carcinoma
Authors: Chi Gang , Pei Jin-Hong , Li Xue-Qing 
Published: June 2022

Abstract
Background
Hepatocellular carcinoma (HCC) is a primary malignant tumor that accounts for approximately 90% of all cases of primary liver cancer worldwide. Microtubule alterations may contribute to the broad spectrum of resistance to chemotherapy, tumor development, and cell survival. This study aimed to assess the value of ribonucleic acid export 1 (RAE1), as a regulator of microtubules, in the diagnosis and prognosis of HCC, and to analyze its correlation with genetic mutations and pathways in HCC.

Results
The mRNA and protein levels of RAE1 were significantly elevated in HCC tissues compared with those in normal tissues. The high expression level of RAE1 was correlated with T stage, pathologic stage, tumor status, histologic grade, and alpha-fetoprotein level. HCC patients with a higher expression level of RAE1 had a poorer prognosis, and the expression level of RAE1 showed the ability to accurately distinguish tumor tissues from normal tissues (area under the curve (AUC) = 0.951). The AUC values of 1-, 3-, and 5-year survival rates were all above 0.6. The multivariate Cox regression analysis showed that RAE1 expression level was an independent prognostic factor for a shorter overall survival of HCC patients. The rate of RAE1 genetic alterations was 1.1% in HCC samples. Gene ontology and kyoto encyclopedia of genes and genomes pathway enrichment analyses indicated the co-expressed genes of RAE1 were mainly related to chromosome segregation, DNA replication, and cell cycle checkpoint. Protein–protein interaction analysis showed that RAE1 was closely correlated with NUP205, NUP155, NUP214, NUP54, and NXF1, all playing important roles in cell division and mitotic checkpoint.

Conclusion
RAE1 can be a potential diagnostic and prognostic biomarker associated with microtubules and a therapeutic target for HCC.