bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid epidemic expansion of the SARS-CoV-2 Omicron BA.2 subvariant during China’s largest outbreaks
Authors: Dai Yeyu 
Published: April 2022

Abstract
A complete and accurate statistical panorama and analysis of cases contracted with the SARS-CoV-2 Omicron BA.2 subvariant are given under the conditions of strict mandatory quarantine and isolation and of a high rate of full vaccination. Sars-Cov-2 is still new, and little is known about either its direction of variation or its propagation laws. No country other than China has been able to disclose every infected case and to have the data of heavily intervening large outbreaks. Here, my study reveals that the BA.2 subvariant can still spread very fast and wide in areas with strict “dynamic zero-COVID strategy”i in China, that there exist in different cities as many as twenty-time large differences in morbidity rate unrelated to any of the influence factors known and that the Omicron BA.2 subvariant is unpredictable of its virulence, although its severe rate of confirmed cases is low. This analysis provides first-hand solitary and valuable information for further research on similar epidemics in the future. It may bring new thoughts for correction of present epidemiological theory and mathematical models. It may also give other countries time to be better prepared for the coming 6th wave driven by Omicron BA.2.
Accurate prediction of microvascular invasion occurrence and effective prognostic estimation for patients with hepatocellular carcinoma after radical surgical treatment
Authors: Xiong Yuling , Cao Peng , Lei Xiaohua , Tang Weiping , Ding Chengming , Qi Shuo , Chen Guodong 
Published: April 2022

Abstract
Background
Hepatocellular carcinoma (HCC) is the third most common cause of cancer death worldwide with an overall 5-year survival rate was less than 18%, which may be related to the tumor microvascular invasion (MVI). This study aims to compare the clinical prognosis of HCC patients with or without MVI after radical surgical treatment, and further analyze the preoperative risk factors related to MVI to detect a new treatment strategy for HCC.
Methods
According to postoperative pathological diagnostic of MVI occurrence, 160 study patients undergoing radical hepatectomy were divided into MVI negative group (n = 68) and MVI positive group (n = 92). The clinical outcomes and prognosis of HCC patients was compared between the two groups, and then the clinical characteristic parameters were analyzed by multivariate Logistic regression to construct a MVI prediction model. Then, the practicability and validity of the model were evaluated, and the clinical prognosis of different MVI risk groups were subsequently compared.
Result
There were no significant differences between the MVI negative and MVI positive group in clinical baseline, haematological and imageological data. Also, the clinical outcome comparison between the two groups presented no significant differences excepted the pathological grading (P = 0.002) and survival and recurrence rate after surgery (P < 0.001). The MVI prediction model, based on preoperative AFP, tumor diameter and TNM stage, presented superior predictive efficacy (AUC = 0.7997) and good practicability (high H-L goodness of fit, P = 0.231). Compared the MVI high-risk group, the patients in the MVI low-risk group shown higher survival rate (P = 0.002) and lower recurrence rate (P = 0.004).
Conclusion
MVI is an independent risk factor of HCC for poor prognosis after radical resection. The MVI prediction model, consist of AFP, tumor diameter and TNM stage, exhibits a superior predictive efficacy and strong clinical practicability for MVI prediction and prognosis estimation, which provides a new therapeutic strategy for clinical standardized treatment of HCC patients.
ARLE GPS: A computational tool to aid solve the creative design of a house. Case study.
Authors: Martins Daniel das Neves 
Published: April 2022

Abstract
The computational tool ARLE GPS "geometric planning solver of floor plan layout", converts the spatial planning of a house, conceptualized as a "wicked" problem, into a "well-defined" problem; and thus, helps the architect to solve it in a rational, innovative, and creative way, using a physical-biological meta-model. The physical model simulates solutions of the candidate FPL repetitively, in real time, and evaluates the geometric qualification of the FPL, representative of the quality of the solution, in an analogy with the physical functional performance of the house. The biological model makes it possible to build and explore design spaces, with the goal of retrieving information about inheritance and genetic transmission of high-performance solutions, to transcribe them into the development of innovative and creative designs. Thus, ARLE GPS evaluates creative design against the social value of the house, represented by its utility/functionality, and the quantitative innovation established by the fulfillment of the home purpose, by the user. Through geometric qualification (QQL) and optimization, in relation to the defining qualification of the house's required performance. (QQA). Associated with the evaluation of the house's performance over its useful life, represented by its usability. Computed by the ARLE GPS robust design model, through the geometric cost of losses (AN) variable, induced by the FPL design solution, as in the case of confined rooms, which persist during the house's lifetime.
Isolated non-immune hydrops fetalis: an observational study on complete spontaneous resolution, perinatal outcome, and long-term follow-up
Authors: Neveling Sophie , Knippel Alexander Johannes , Kozlowski Peter 
Published: April 2022

Abstract
Purpose The aim of our study was to investigate spontaneous resolution and postnatal outcome in non-immune hydrops fetalis (NIHF). We specifically studied NIHF cases that occurred without any other anomalies in the prenatal diagnostic workup, defined as isolated NIHF (iNIHF).MethodsTo identify iNIHF we retrospectively classified prenatal findings of 703 NIHF singletons, diagnosed in our prenatal referral center between 1997 and 2016. We studied the occurrence of prenatal resolution in iNIHF and linked it to the perinatal outcome. We obtained long-term outcome by contacting the parents, children, and the pediatricians and listed all functional and structural anomalies and temporary logopedic, psychosocial and motoric impairments.ResultsAmong 73 iNIHF cases, 57 (78.1%) resolved completely prenatally. The baby-take-home rate was 98.2% in these cases. In contrast, the baby-take-home rate in the subgroup without complete resolution was 25.0%. We achieved pediatric long-term outcome in 28 of 60 survivors (46.6%) of iNIHF with a mean follow-up period of 10.4 years. Among these 28 children, fetal hydrops had completely resolved prenatally in 27 cases and had regressed to a mild effusion in one case. In the pediatric development, two children had significant functional impairment and three children showed recurrent skin edema.ConclusionComplete spontaneous resolution was the most common intrauterine course of iNIHF in our collective. Completely resolved iNIHF had a favorable perinatal outcome in our study. Our data on the long-term outcomes are consistent with the assumption of an increased rate of functional impairments. TRIAL REGSTRATION NUMBERInternal study number of Heinrich-Heine-University, Duesseldorf: 6177RDate of registration: December 2017
Weighted gene coexpression network analysis reveals negative regulation of maximum left ventricular wall thickness by carboxylesterase 1 and cathepsin C in hypertrophic cardiomyopathy
Authors: Kuang Ye , Wang Jia , Dong Yulin , Wang Yang , Ji Yong , Gao Hui , Peng Chuanmei 
Published: April 2022

Abstract
Hypertrophic cardiomyopathy (HCM) is a primary cardiomyopathy characterized by hypertrophic cardiomyocytes. It is one of the leading causes of sudden death in adolescents. However, the molecular mechanism of HCM is not clear. In our study, ribonucleic acid (RNA) sequence data of myocardial tissue in HCM patients was extracted from the Gene Expression Omnibus (GEO) database and analyzed by weighted gene co-expression network analysis (WGCNA). A total of 31 co-expression modules were identified. The co-expression black module significantly correlated with maximum left ventricular wall thickness (Maxi LVWT). We screened the differentially expressed mRNAs between normal tissues and HCM tissues using the dplyr and tidyr packet in R3.6.2. The genes in the black module and differentially expressed genes were further intersected. We found that the expression of carboxylesterase 1 (CES1) and cathepsin C (CTSC) was down regulated in HCM tissues, and negatively correlated with Maxi LVWT. We further verified the above conclusion in clinical samples from HCM patients. We found the expression of CES1 and CTSC was down regulated in HCM tissues, and negatively correlated with Maxi LVWT. The above conclusion was further verified in clinical samples from HCM patients. In summary, the study suggests that CES1 and CTSC negatively regulate development of HCM and have potential as a therapeutic and diagnostic target for HCM.
Hyperphosphatemia and its Relationship with Blood Pressure, Vasoconstriction, and Endothelial Cell Dysfunction in Hypertensive Hemodialysis Patients
Authors: Jung Jinwoo , Jeon-Slaughter Haekyung , Nguyen Hang , Patel Jiten , Sambandam Kamalanathan K. , Shastri Shani , Buren Peter Noel 
Published: April 2022

Abstract
BackgroundHyperphosphatemia occurs frequently in end-stage renal disease patients on hemodialysis and is associated with increased mortality. Hyperphosphatemia contributes to vascular calcification in these patients, but there is emerging evidence that it is also associated with endothelial cell dysfunction. MethodsWe conducted a cross-sectional study in hypertensive hemodialysis patients. We obtained pre-hemodialysis measurements of total peripheral resistance index (TPRI, non-invasive cardiac output monitor) and plasma levels of endothelin-1 (ET-1) and asymmetric dimethylarginine (ADMA). We ascertained the routine peridialytic blood pressure (BP) measurements from that treatment and the most recent pre-hemodialysis serum phosphate levels. We used generalized linear regression analyses to determine independent associations between serum phosphate with BP, TPRI, ET-1, and ADMA while controlling for demographic variables, parathyroid hormone (PTH), and interdialytic weight gain. ResultsThere were 54 patients analyzed. Mean pre-HD supine and seated systolic and diastolic BP were 164 (27), 158 (21), 91.5 (17), and 86.1 (16) mmHg. Mean serum phosphate was 5.89 (1.8) mg/dL. There were significant correlations between phosphate with all pre-hemodialysis BP measurements (r=0.3, p=.04; r=0.4, p=.002; r=0.5, p<.0001; and r=0.5, p=.0003.) The correlations with phosphate and TPRI, ET-1, and ADMA were 0.3 (p=.01), 0.4 (p=.007), and 0.3 (p=.04). In our final linear regression analyses controlling for baseline characteristics, PTH, and interdialytic weight gain, independent associations between phosphate with pre-hemodialysis diastolic BP, TPRI, and ET-1 were retained (β=4.33, p=.0002; log transformed β=0.05, p=.005; reciprocal transformed β= -0.03, p=.047). ConclusionsSerum phosphate concentration is independently associated with higher pre-HD BP, vasoconstriction, and markers of endothelial cell dysfunction. These findings demonstrate an additional negative impact of hyperphosphatemia on cardiovascular health beyond vascular calcification. The study was part of a registered clinical trial, NCT01862497 (May 24, 2013).
Exploring Effects of the HEP® (Homeostasis-Enrichment-Plasticity) Approach as a Comprehensive Therapy Intervention for an Infant with Cerebral Palsy: A Case Report
Authors: Balıkçı Aymen 
Published: April 2022

Abstract
Background: Cerebral palsy (CP) is a common non-progressive neurodevelopmental disorder which causes developmental disabilities in children. Varied interventions for CP exist to address medical and physical needs but with limited effectiveness evidence. Environmental Enrichment (EE) is an animal model intervention for many neurodevelopmental disorders, including CP, with considerable positive effects. This case report defines the “HEP®” (Homeostasis-Enrichment-Plasticity) approach, which is based upon principles of EE and ecological theories of development, and describes its’ use to promote the developmental and functional skills of an infant with CP.Methods: Parent interviews and assessment data were completed before and after intervention. Data was gathered by developmental history, systematic observation of behaviors in the clinical setting and at home, Beck Anxiety Inventory (BAI), Infant-Toddler Symptom Checklist, the Sensory Profile Infant/Toddler, Peabody Developmental Motor Scales-2, Gross Motor Function Measurement-88 (GMFM-88), the Gross Motor Function Classification System (GMFCS) and Pediatric Evaluation of Disability Inventory (PEDI). The HEP® approach intervention was implemented one time per week for 12 months.Results: Following the HEP® approach intervention, self regulation and sensory processing scores improve to typical performance ranges. GMFM-88 total score improved from 45/264 to 123/264. The Peabody found all Gross Motor (54 to 110), Fine Motor (65 to 117) and Total Motor Quotient (119 to 227) scores increased significantly after intervention. Post- intervention observations showed significant gross motor progress with movement fromGMFCS Level IV to Level I. Performance on the Functional Skills Scales and Caregiver Assistance Scales of PEDI also demonstrated significant gains.Conclusions: A definition and detailed description of the HEP® approach intervention is presented here for the first time. The case report demonstrated preliminary evidence for the effectiveness of the HEP® approach on self-regulation, sensory processing, motor development, functional skills, and caregiver assistance with an infant with CP. Additional studies are needed to validate the findings.
Sexual Dysfunction After Partial Penectomy for Penile Cancer: Updated Report from A Vietnamese Patient Cohort
Authors: Nguyen Quang , Bui Van-Quang , Vo Hoang-Long 
Published: April 2022

Abstract
Objectives
This study sought to evaluate sexual dysfunction of patients who underwent partial penectomy for carcinoma of the penis.
Method
We included the individuals who aged 18 years and older and received the treatment with partial penectomy for penile carcinoma. Information on sexual function after partial penectomy were evaluated to be erectile dysfunction, premature ejaculation, frequency of sexual intercourse within one month, time to have sex again, delayed ejaculation, decreased sexual desire, partners’s attitudes toward sex, and partner’s sexual avoidance.
Results
Between January 2016 and December 2019, there were 22 eligible patients who received the treatment with partial penectomy, with the mean age at operation of 50.3 ± 11.6 years. Three (13.6%) patients had phimosis and one (4.5%) patient had genital warts. 17 patients were fully monitored postoperatively, 2 patients died and 3 patients were uncontactable. In 17 patients who were followed up after partial penectomy in this study, 13 of them had sexual intercourse after surgery (76.5%), when there were four patients who did not have sex again after surgery. There was significant decrease in the mean frequency of sexual intercourse within one month pre-operatively compared to post-operatively (7.6 ± 2.2 times vs. 3.4 ± 2.1 times). The average time to have sex again after surgery was 92.8 ± 92.5 days. In the sample of 13 patients having sexual intercourse again after partial penectomy, most them were no erectile dysfunction (n = 11; 84.6%). The degree of erectile dysfunction was mild in one patient (7.7%) and, mild to moderate in one patient (7.7%). There were delayed ejaculation in 12 (92.3%) patients and decreased sexual desire in 11 (64.7%) patients. 13 (76.5%) patients reported partners’s disappointed attitudes toward sex after surgery. 9 (69.2%) patients reported partner’s sexual avoidance after partial penectomy.
Conclusions
Besides the sexual dysfunction of penile carcinoma patients after partial penectomy was known, our preliminary findings suggest that notable sexual problems that patients experiencing after surgery were decreased frequency of sexual intercourse and satisfaction of both patient and partner.
Modeling and control of a CDPM-based Smart Crane
Authors: GUESMI Fatma , Azouz Naoufel , NEJI Jamel 
Published: April 2022

Abstract
As part of the development of Large Capacity Airships, this paper presents the design and the mathematical model of an innovative smart crane CHAYA-SC, based on the principle of Cable Driven Parallel Manipulators as well as its stabilization. This crane is mounted on the airship hold and intended for handling at altitude. The highest level of precision is required. Thus, the model developed includes the oscillations as well as the transverse and longitudinal vibrations of the heavy cable supporting the load to be handled. The highly nonlinear partial differential equations (PDE) and the ordinary derivative equations (ODE) that govern the motion of the system are obtained via the Lagrange equations coupled with a modal synthesis. As a first validation of the modeling, a simple control vector is applied to stabilize the airship and its load under the effect of a squall. Numerical simulations are presented at the end of the paper to show the efficiency of the design.
Empowerment training to support service user involvement in mental health system strengthening in rural Ethiopia: a mixed-methods pilot study
Authors: Abayneh Sisay , Lempp Heidi , Rai Sauharda , Girma Eshetu , Getachew Medhanit , Alem Atalay , Kohrt Brandon A. , Hanlon Charlotte 
Published: April 2022

Abstract
BackgroundIncreased service user involvement is recommended to improve weak mental health systems in low-and middle-income countries (LMICs). However, involvement is rarely implemented and interventions to support involvement are sparse. In this study we evaluated the acceptability, feasibility and perceived outcomes of an empowerment and training program for service users and health professionals to facilitate service user involvement in mental health system strengthening in rural Ethiopia.MethodsREducing Stigma among HealthcAreProvidErs (RESHAPE) is a training curriculum for service users, their caregivers and aspirational health workers, which uses PhotoVoice methodology, to prepare them in participation of mental health systems strengthening in LMICs. We delivered the RESHAPE training augmented with empowerment content developed in Ethiopia. The interactive face-to-face training was delivered to service users and caregivers (over 10 days), and health professionals (one day) separately. The study was an uncontrolled, convergent mixed-methods design. The quantitative data consisted of process data, satisfaction questionnaire, and a retrospective pre-test survey. Qualitative data included exit and follow-up in-depth interviews with the service users. Descriptive statistics were performed for quantitative data, and qualitative data were thematically analysed. The findings were integrated through triangulation for convergent themes following analysis.Results12 service users, 12 caregivers and 18 health professionals were enrolled, and completed the training. Participants valued the content and delivery process; the standard of the training program met their expectations and participation led to positive gains in understanding about mental illness, stigma, service-user involvement and human rights. The qualitative findings identified positive impacts, including increased self-confidence, sense of empowerment, social - and perceived therapeutic benefits.ConclusionsWe found that the RESHAPE training with added content for Ethiopia, delivered using the PhotoVoice methodology, is feasible, acceptable and of value to develop and implement training programmes which can empower service users to be involved in mental health system strengthening in this setting. Further study to assess the impact on health systems strengthening is warranted.
Neuroecotoxicology: Effects of Environmental Heavy Metal Exposure on the Brain of African Giant Rats and the contribution of Vanadium to the Neuropathology, Part 1
Authors: Usende Ifukibot Levi , Olopade James , Azeez Idris Ayodeji , Andrioli Anna , Bankole Oluwamolakun O , Olopade Funmilayo E , Nafady Allam A , Bentivoglio Marina 
Published: April 2022

Abstract
Increased exploitation of minerals has led to pollution of confined environments as documented in Nigeria Niger Delta. Information on the effects on brain of such exposure is limited. Due to its exploratory activities, the African giant rat (Cricetomys gambianus) (AGR) provides a unique model for neuroecotoxicological research to determine levels of animal and human exposure to different pollutants. This study aims to unravel neuropathological features of AGR sampled from three agro-ecological zones of Nigeria. Fifteen AGR were sampled according to previously determined data on heavy metal exposure: high vanadium, high lead, and low metals. Eighteen AGR were collected from low metal zone and divided into two groups. Control group received vehicle while SMV exposed group received 3mg/kg sodium metavanadate (SMV) intraperitoneally for 14days. Brain immunohistochemical analyses were conducted, and ultrastructural changes were studied in experimentally exposed group. Results showed significant loss of tyrosin hydroxylase, parvalbumin, orexin-A and melanin concentration hormone containing neuronal populations in brains obtained from high vanadium and high lead zones and in experimentally intoxicated SMV groups. Similarly, significant decrease numbers of dendritic arborations; extracellular matrix density, perineuronal nets; astrocytes and microglia activations are documented in same groups. Ultrastructural studies revealed mass denudation, cilia loss, disintegration of ependymal layer and intense destructions of myelin sheaths in SMV exposed group. These are the first “neuroecotoxicological” findings in distinct neuronal cells. The implications of these findings are highly relevant for human population living in these areas, not only in Nigeria but also in similarly polluted areas elsewhere in the world.