bluuebunny/crossref_metadata_2025_split huggingface dataset:
Модель управління процесом забезпечення сил оборони боєприпасами при проведенні операцій з відсічі збройної агресії
Authors: Бутенко М. , Гріненко О. , Кутовий О. , Васюхно С. 
Published: November 2022

На сьогодні гостро стоїть проблема забезпечення військ (сил) оборонними ресурсами: бронетехнікою, літаками, засобами протиповітряної оборони, кораблями тощо. Складно вирішується питання забезпечення боєприпасами. Головна причина полягає у тому, що до цього часу не вдалося створити у складі оборонно-промислового комплексу України розвинутої боєприпасної галузі. Прагнення України до вступу в європейський союз та НАТО потребує вирішення питань створення боєприпасної галузі, управління її функціонуванням та визначення системи управління цим процесом.
Метою статті є визначення моделі управління процесом забезпечення сил оборони боєприпасами та ролі центральних органів виконавчої влади, органів державної влади, органів військового управління відповідальних за впровадження заходів забезпечення військ (сил) боєприпасами.
Для удосконалення та підвищення ефективності управління процесом забезпечення військ (сил) боєприпасами відповідно до визначених потреб пропонується покласти відповідальність за:
управлінські функції щодо підготовки виробництва, виробництва та забезпечення військ (сил) боєприпасами в мирний та воєнний час Збройних Сил України, інших військових формувань, Оперативно-рятувальної служби цивільного захисту – на Міністерство оборони України;
мобілізаційну підготовку щодо функціонування боєприпасної галузі в особливий період: з питань наукового, методичного, організаційного керівництва, загального планування та звітності – на Мінекономіки України;
мобілізаційну підготовку підприємств-виконавців державного оборонного замовлення, мобілізаційні завдання (замовлення), планування та звітність – на Міністерство оборони України.
Російсько-українська війна: особливості реалізації загроз державному суверенітету України та перспективи виходу з війни
Authors: Шевченко М. , Зозуля О. , Храпач Г. , Лепіхов А. 
Published: November 2022

Російська Федерація (РФ) реалізує стратегію, спрямовану на руйнацію нинішньої європейської системи безпеки, де збройна агресія РФ проти України та знищення її державності є одним з етапів реалізації цієї стратегії.За умов сьогодення Україна зазнає комплексного тиску з боку РФ, який включає керовані з єдиного центру політичні, економічні, енергетичні, інформаційні, військові та розвідувально-підривні заходи. Ця обставина і визначає зв’язок загальної проблеми забезпечення національної безпеки України з найбільш важливими науковими та практичними завданнями дослідження технологій війни.
У статті з’ясовано особливості реалізації загроз державному суверенітету України під час російсько-української війни та в оцінені альтернативні варіанти національної політики України щодо формування її статусу відносно міжнародного оточення і структур колективної безпеки.
Доведено, що стратегічний задум керівництва РФ щодо повернення України в свою зону геополітичного панування реалізовується на основі використання таких моделей загроз державному суверенітету та територіальній цілісності: “обмеженого суверенітету”, воєнно-політичного конфлікту, регіональної дезінтеграції держави, гібридної війни, дестабілізації економічної та суспільно-політичної систем.
Вбачається, що в сучасних умовах російсько-української війни у стратегічному вимірі перспективним є блоковий статус України, що передбачає реалізацію стратегії повної інтеграції України до ЄС, а також створення нових регіональних структур безпеки у рамках більш широкої архітектури європейської або євроатлантичної безпеки.
Correlación entre el CBR de laboratorio, el índice DCP y propiedades físicas y mecánicas de suelos granulares
Authors: Portilla Yandún Favio Paul 
Published: November 2022

Introducción. El presente estudio propone la utilización de un ensayo simple de evaluación del suelo, como es la Penetración Dinámica de Cono (DCP) y su correlación con el CBR (Relación de Soporte California), un ensayo ampliamente conocido y utilizado para evaluación de suelos de subrasante, subbase y base, el cual es necesario para el diseño y control de la estructura de pavimentos. Este estudio no pretende reemplazar la metodología de evaluación normada de suelos, sino fortalecer la base del diseño preliminar de pavimentos. Objetivo. Determinar el nivel de correlación existente entre el CBR, DCP y propiedades físicas y mecánicas de suelos granulares. Metodología. Para la realización del estudio se realizaron ensayos de campo y laboratorio para determinar las propiedades, para lo cual se extrajeron 30 muestras de suelo en la sierra norte y centro del Ecuador. La obtención de correlaciones entre estas propiedades se realizó utilizando el método estadístico de mínimos cuadrados. Resultados. Se obtuvo la distribución granulométrica, límites de consistencia, clasificación SUCS y AASHTO, densidad seca máxima y humedad óptima, DCP y CBR de las muestras ensayadas. Con estos valores se analizaron varias correlaciones de dos y tres variables entre estas las propiedades. Conclusión. Se concluyó que existe un buen nivel de correlación entre varias de las propiedades del suelo analizadas. La correlación CBR-DCP no es significativamente aceptable, sin embargo, se pueden obtener valores cercanos de CBR mediante el uso de otras correlaciones presentadas en esta investigación. Área de estudio o rama de la ciencia: Ingeniería Civil
Pachydermoperiostosis with Chronic Diarrhoea: A Case Report
Authors: Khan Muhammad Shaista Ali , Shazzad Md Nahiduzzamane , Ahmed Shamim , Haq Syed Atiqul 
Published: November 2022

Pachydermoperiostosis (PDP) is a rare autosomal disorder characterized by periostosis, clubbing, thickening of the skin (pachyderma) of the face and scalp, seborrhea and hyperhydrosis. It is the primary form of hypertrophic osteoarthropathy (HOA), the other name of which is Touraine- Solente-Golé syndrome. PDP has various organ involvements and there are some rare associations of PDP with other disorders. Here we describe a 16-year-old boy who presented with skin and skeletal manifestations typical of PDP who also had chronic diarrhea, abdominal pain and weight loss. After giving treatment with risedronate sodium and mesalazine he got significant improvement in his skeletal and abdominal complaints.
Bangladesh Med J. 2021 Sept; 50(3): 52-55
Comparison of Glucose Administration Routes to Determine Glucose Tolerance in Old and Young Mice
Authors: Swaminathan Anandini , Libnickienė Indrė , Venckūnas Tomas , Degens Hans 
Published: November 2022

Background: It has been observed that old mice have a better tolerance to glucose than young after an intraperitoneal injection of glucose. We hypothesized that an intraperitoneal injection of glucose overestimates glucose tolerance in old mice.
Methods: We assessed differences in glucose tolerance outcomes in 2- (young, n=23) and 23- to 27-month-old (old, n=23) male C57BL/6J mice after an intraperitoneal (IP) or intravenous (IV) injection, or oral gavage (OG) of glucose.
Results: The area under the curve (AUC) of the changes of blood glucose concentration over 2 hours after glucose administration was lower in old than young animals (p<0.001). The AUC was higher after IV than either IP or OG (p<0.001). However, normalized to peak glucose concentration, the time course was similar in young and old animals, and was – except for an earlier peak in IV than OG (p=0.013) – independent of route of administration.
Conclusion: We suggest that 1) to determine glucose tolerance the time course of changes in glucose concentration rather than the AUC, which is significantly affected by excursion magnitude, is preferable; 2) glucose tolerance can be measured equally well with IP, IV and OG; 3) there is no significant age-related difference in glucose tolerance in mice.
Keywords: glucose tolerance test, glucose uptake, aging, glucose intolerance, mice, diabetes.
Spanish Abstract Meaning Representation: Annotation of a General Corpus
Authors: Shira Wein  , Lucia Donatelli  , Ethan Ricker  , Calvin Engstrom  , Alex Nelson  , Leonie Harter  , Nathan Schneider  
Published: November 2022

Abstract Abstract Meaning Representation (AMR), originally designed for English, has been adapted to a number of languages to facilitate cross-lingual semantic representation and analysis. We build on previous work and present the first sizable, general annotation project for Spanish AMR. We release a detailed set of annotation guidelines and a corpus of 486 gold-annotated sentences spanning multiple genres from an existing, cross-lingual AMR corpus. Our work constitutes the second largest non-English gold AMR corpus to date. Fine-tuning an AMR to-Spanish generation model with our annotations results in a BERTScore improvement of 8.8%, demonstrating initial utility of our work.
Doughty-electronegative heteroatom-induced defective MoS2 for the hydrogen evolution reaction
Authors: Xiao Zhaohui , Luo Shengdao , Duan Wei , Zhang Xu , Han Shixing , Liu Yipu , Yang Liang , Lin Shiwei 
Published: November 2022

Producing hydrogen through water electrolysis is one of the most promising green energy storage and conversion technologies for the long-term development of energy-related hydrogen technologies. MoS2 is a very promising electrocatalyst which may replace precious metal catalysts for the hydrogen evolution reaction (HER). In this work, doughty-electronegative heteroatom defects (halogen atoms such as chlorine, fluorine, and nitrogen) were successfully introduced in MoS2 by using a large-scale, green, and simple ball milling strategy to alter its electronic structure. The physicochemical properties (morphology, crystallization, chemical composition, and electronic structure) of the doughty-electronegative heteroatom-induced defective MoS2 (N/Cl-MoS2) were identified using SEM, TEM, Raman, XRD, and XPS. Furthermore, compared with bulk pristine MoS2, the HER activity of N/Cl-MoS2 significantly increased from 442 mV to 280 mV at a current of 10 mA cm−2. Ball milling not only effectively reduced the size of the catalyst material, but also exposed more active sites. More importantly, the introduced doughty-electronegative heteroatom optimized the electronic structure of the catalyst. Therefore, the doughty-electronegative heteroatom induced by mechanical ball milling provides a useful reference for the large-scale production of green, efficient, and low-cost catalyst materials.
Metagenomic next-generation sequencing assists the diagnosis treatment of fungal osteoarticular infections
Authors: Zhang Chaofan , Lin Yunzhi , Huang Changyu , Huang Zida , Fang Xinyu , Bai Guochang , Zhang Zeyu , Li Wenbo , Zhang Wenming 
Published: November 2022

BackgroundFungal osteoarticular infection (FOI) is not commonly seen in clinical practice but proposes a great challenge to orthopedic surgeons. In this study, we aimed to investigate the risk factors, the clinical features, and surgical outcomes of FOI in our institution. Specifically, we aimed to explore the role of metagenomic next-generation sequencing (mNGS) in the diagnosis and treatment of FOI.MethodsAll the patients who were diagnosed and managed with FOI in our institution from January 2007 to December 2020 were retrospectively reviewed, including primary fungal implant-related infection, primary fungal osteomyelitis or arthritis, and fungal infections secondary to bacterial osteomyelitis or implant-related bacterial infections. The potential risk factors and the clinical and surgical features were analyzed. The pathogen data were compared between culture and the mNGS test.ResultsA total of 25 patients were included, namely, 12 primary implant-related infections, 7 primary fungal osteomyelitis or arthritis, and 6 fungal infections secondary to bacterial osteomyelitis or implant-related bacterial infections. Most cases had undergone multiple surgeries or long-term antibiotic treatment. Diagnosis was mainly based on microbial culture and the mNGS test. Optimization of culture methods and the use of mNGS assisted the diagnosis. Specifically, mNGS was performed in 12 patients, 5 of whom were culture-negative. In the remaining seven cases, mNGS demonstrated the same results as culture. Management of FOI was complicated as most patients required multiple surgeries followed by long-term antifungal treatment. In selected cases, antifungal-impregnated cement spacer retention can be an optional choice. The overall success rate was 100% (25/25) for our cohort.ConclusionWe concluded that patients with comorbidities and a history of multiple surgeries or long-term antibiotics are under higher risk for FOI. Use of mNGS assists the diagnosis and treatment of FOI. Surgery combined with long-term antifungal treatment achieved satisfactory outcomes. In selected cases, antifungal-impregnated cement spacer retention can be an optional treatment choice.
Efficacy and safety of dorzagliatin for type 2 diabetes mellitus: A meta-analysis and trial sequential analysis
Authors: Yu Yunfeng , Yang Xingyu , Tong Keke , Yin Shuang , Hu Gang , Zhang Fei , Jiang Pengfei , Zhou Manli , Jian Weixiong 
Published: November 2022

ObjectiveTo evaluate the efficacy and safety of dorzagliatin in the treatment of type 2 diabetes mellitus (T2DM) by using meta-analysis and trial sequential analysis (TSA).MethodSearch for clinical trials of dorzagliatin for T2DM in eight databases, with a time limit of build to July 2022. The included studies that met the requirements were carried out for meta-analysis and TSA.ResultsIn terms of efficacy endpoints, meta-analysis showed that dorzagliatin decreased glycated hemoglobin A1c(HbA1c) [mean difference (MD) −0.65%, 95% confidence interval (CI) −0.76 ~ −0.54, P &lt; 0.00001], fasting plasma glucose (FPG) (MD −9.22 mg/dL, 95% CI −9.99 ~ −8.44, P &lt; 0.00001), 2 h postprandial glucose (2h-PPG) (MD −48.70 mg/dL, 95% CI −55.45 ~ −41.96, P &lt; 0.00001), homeostasis model assessment 2 of insulin resistance (HOMA2-IR) (MD −0.07, 95% CI −0.14 ~ −0.01, P = 0.03) and increased homeostasis model assessment 2 of ß-cells function (HOMA2-β) (MD 2.69, 95% CI 1.06 ~ 4.31, P = 0.001) compared with placebo. And TSA revealed that the benefits observed for the current information set were conclusive, except for HOMA2-IR. In comparison with placebo, dorzagliatin increased triglyceride(TG) (MD 0.43 mmol/L, 95% CI 0.30 ~ 0.56, P &lt; 0.00001), total cholesterol (TC) (MD 0.13 mmol/L, 95% CI 0.05 ~ 0.21, P = 0.001), body weight (MD 0.38 kg, 95% CI 0.12–0.63, P = 0.004) and body mass index (BMI) (MD 0.14 kg/m2, 95% CI 0.05–0.24, P = 0.003), while low density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were comparable. And TSA demonstrated that TG, TC, body weight, and BMI were conclusive. In terms of safety endpoints, dorzagliatin increased total adverse events (AEs) [risk ratio (RR) 1.56, 95% CI 1.06 ~ 2.30, P = 0.03], while serious AEs, hyperlipidemia, and hypoglycaemia were all comparable. And TSA indicated that the results need to be confirmed by additional studies. Harbord regression showed no publication bias.ConclusionDorzagliatin was effective in lowering glycemia, reducing insulin resistance and improving islet ß-cells function without affecting blood pressure, LDL-C, and HDL-C. Although dorzagliatin caused a mild increase in TG and TC, it did not increase the incidence of hyperlipidemia, and the small increases in body weight and BMI were not clinically significant enough. In terms of safety, the total AEs caused by dorzagliatin may be a cumulative effect of single AEs, with no drug-related adverse event being reported at a higher incidence than placebo alone. Dorzagliatin's serious AEs, hyperlipidemia, and hypoglycemia are comparable to that of placebo, and dorzagliatin has a good safety profile.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=371802 identifier: CRD42022371802.
Electrocardiographic phenotype of exercise-induced arrhythmogenic cardiomyopathy: A retrospective observational study
Authors: Miljoen Hielko , Spera Francesco , Van Kolen Katrien , Saenen Johan , Claessen Guido , Huybrechts Wim , Sarkozy Andrea , Heidbuchel Hein 
Published: November 2022

IntroductionThe right ventricle can be susceptible to pathologic alterations with exercise. This can cause changes to the ECG. Our aim was to identify the electrocardiographic phenotype of exercise induced (ExI) arrhythmogenic cardiomyopathy (ACM).MethodsA retrospective analysis of ECGs at rest, peak exercise and 1 min of recovery in four groups of individuals was performed: Arrhythmogenic Cardiomyopathy with genetic confirmation (Gen-ACM; n = 16), (genetically negative) ExI-ACM (n = 15), control endurance athletes (End; n = 16) and sedentary individuals (Sed; n = 16). The occurrence of ventricular arrhythmias (VA) and, at each stage, QRS duration, Terminal Activation Delay (TAD), the ratio of the sum of the QRS durations in the right precordials (V1-V3) over that in the left precordials (V4-V6; R/L duration ratio), the presence of complete RBBB and T-wave inversion (TWI) beyond lead V2 were evaluated.ResultsAt rest, complete RBBB was exclusively found in Gen-ACM (6%) and ExI-ACM (13%). No epsilon waves were identified. TWI beyond V2 was uniquely present in Gen-ACM (73%) and ExI-ACM (38%; p &lt; 0.001). VA was present in Gen-ACM (88%); ExI-ACM (80%), End (25%) and Sed (19%; p &lt; 0.001). The presence of R/L duration ratio of &gt;1.2 and TAD ≥ 55 ms were not significantly different over the four groups (p = 0.584 and p = 0.218, respectively). At peak exercise the most striking finding was a significant decrease of the R/L duration ratio in individuals with ACM, which was the result of lateral precordial QRS prolongation.ConclusionExI-ACM shares important ECG-features with Gen-ACM, suggesting a similar underlying pathogenesis regardless of the presence or absence of desmosomal mutations.
A study of intercultural adaptation in the Sino-American joint training dual degree programs
Authors: Yueyue Cai , Nordin Nor Akmar , Panatik Siti Aisyah 
Published: November 2022

IntroductionThis study focuses on the factors influencing the intercultural adaptation stress and strategies of students in the Sino-American Joint Training Dual Degree Program.MethodsA total number of 400 questionnaires were distributed to Chinese students who participating in the Program and the 355 responded. Motivation and Expectation Scale, Acculturative Stress Scale for International Students and The Intercultural Adaptation Strategies Scale were adopted to measure variables. Regression test, one-way Analysis of Variance (ANOVA) and Structural Equation Model (SEM) were applied to analyze the survey data.ResultsThe results revealed that the number of local friends, the length of stay in the US, the motivation to study abroad, and the expectation to study abroad have a negative influence on the intercultural adaptation stress of the students. The greater the number of local friends, the longer the length of stay of study abroad, the stronger the motivation and expectation to study abroad, their intercultural adaptation strategies favor integration and assimilation.DiscussionBased on the findings, this study examines which teaching and learning management methods Chinese institutions should apply to help students reduce the negative effects of intercultural adaptation stress and to choose intercultural adaptation strategies for integration and assimilation when undertaking teaching and learning activities for the Sino-American Joint Training Dual Degree Program.
Complex impacts of gallstone disease on metabolic syndrome and nonalcoholic fatty liver disease
Authors: Lyu Jingting , Lin Qinghong , Fang Zhongbiao , Xu Zeling , Liu Zhengtao 
Published: November 2022

BackgroundPatients with gallstone disease (GSD) often have highly co-occurrence with metabolic syndrome (MetS) and Nonalcoholic fatty liver disease (NAFLD) both associated with insulin resistance (IR). Meanwhile, highly prevalence of NAFLD was found in patients who received cholecystectomy. However, the associations of GSD with MetS, NAFLD is inconsistent in the published literature. And risk of cholecystectomy on NAFLD is unclear.MethodsWe searched the Medline EMBASE and WOS databases for literature that met our study topic. To be specific, studies with focus on associations between GSD and MetS/NAFLD, and risk evaluation on cholecystectomy and NAFLD incidence were enrolled for further analysis. The random effect model was used to calculate the combined relative ratio (RR) and odds ratio (OR)and 95% confidence interval (CI).ResultsSeven and six papers with focus on connections between GSD and NAFLD/MetS prevalence. Correspondingly, seven papers with focus on risk of cholecystectomy on NAFLD occurrence were also enrolled into meta-analysis. After pooling the results from individual study, patients with GSD had higher risk of MetS (OR:1.45, 95%CI: 1.23-1.67, I2 = 41.1%, P=0.165). Risk of GSD was increased by 52% in NAFLD patients (pooled OR:1.52, 95%CI:1.24-1.80). And about 32% of increment on NAFLD prevalence was observed in patients with GSD (pooled OR: 1.32, 95%CI:1.14-1.50). With regard to individual MetS components, patients with higher systolic blood pressure were more prone to develop GSD, with combined SMD of 0.29 (96%CI: 0.24-0.34, P&lt;0.05). Dose-response analysis found the GSD incidence was significantly associated with increased body mass index (BMI) (pooled OR: 1.02, 95%CI:1.01-1.03) in linear trends. Patients who received cholecystectomy had a higher risk of post-operative NAFLD (OR:2.14, 95%CI: 1.43-2.85), P&lt;0.05). And this impact was amplified in obese patients (OR: 2.51, 95%CI: 1.95-3.06, P&lt;0.05).ConclusionOur results confirmed that controls on weight and blood pressure might be candidate therapeutic strategy for GSD prevention. And concerns should be raised on de-novo NAFLD after cholecystectomy.
Toxic effects of combined exposure of tritiated water and genistein on the growth and development of zebrafish and its mechanism
Authors: Cui Fengmei , Zhang Qixuan , Wan Jun , Sun Liang , Chen Na , Xue Huiyuan , Wang Tianzi , Luo Fajian , Chen Qiu , Tu Yu 
Published: November 2022

Water pollution and control are important issues of our lasting concern. Environmental media often contains a variety of compounds. Tritium is widely present in nature due to human activities. As an endocrine disruptor, genistein is widely found in water body. Will it cause damage when combined with tritiated water and genistein? In this study, Zebrafish embryos were randomly divided into 4 groups: blank control group (simple E3 medium), tritiated water exposure group (tritiated water with a final concentration of 3.7*102Bq/mL in the medium), and genistein exposure group (the final concentration of 1.4 mg/L genistein in the medium) and the combined exposure group of tritiated water and genistein (3.7*102 Bq/mL tritium water +1.4 mg/L genistein). The results show that tritiated water with 3.7*102 Bq/ml exposure alone did not affect the development of zebrafish embryos. However, the survival rate, hatching rate and heart rate of zebrafish larvae decreased combined exposure with genistein, and the abnormality rate and apoptotic cells in the embryos and the level of oxidative stress increased. The results of RNA sequencing showed that the combined exposure of tritiated water and genistein affected the gene expression of zebrafish embryos. Differential genes were mainly enriched in many pathways, such as p53 signaling pathway, steroid hormone biosynthesis, PPAR signaling pathway, metabolism of xenobiotics by cytochrome P450. The results of qRT-PCR and gene knockout experiment showed that cyp19a1b gene may plays an important role in the toxic effects of combined exposure.