bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nikolay Gogol and Raphael Patkanyan: The Philosophy of Horror
Authors: MAKARYAN Albert , SOGHOYAN Astghik , SHARURYAN Haykanush 
Published: August 2022

The article is dedicated to the study of the artistic impact of the Russian writer Nikolay Gogol (1809-1852) on the creation of the Armenian author Raphael Patkanyan (1830-1892). The object of the research is the horror stories and their philosophy. From this perspective, Patkanyan appears as a student of the Gogol school of horrors by masterfully using the artistic technique of his teacher. The first parallel is the place and time of the action. Night becomes the time axis of the stories, and the plot turns around national holidays - Russian Navi day, Ivan Kupala, Christmas, Armenian Carnival, etc. Actions take place in a cursed or enchanted place (a scary house, an old church, hell, a mortuary, a cemetery, etc.), which allows the two realities to collide, as a result of which extramundane forces penetrate into our world. By taking the national folklore as a basis, both authors set the plot of mythical characters in motion portraying witches, demons, spirits, zombies and other terrible creatures as antagonists. The works of both authors are similar in terms of some functional motifs like the sale of the soul to the devil, metamorphoses, dance and laughter of death, implying specific rituals.
Jelajah Kreativitas Seni Menuju New Normal
Authors: Listiowati Nensi 
Published: August 2022

AbstrakHampir seluruh bidang kegiatan manusia, termasuk seni rupa, terdampak oleh wabah Covid-19. Berbagai alternatif cara dicoba untuk mempertahankan berjalannya industri di tengah situasi pandemi. Pameran fisik dan residensi seniman harus berubah bentuk menjadi pameran dan interaksi termediasi teknologi. Beragam platform digital kemudian hadir untuk menggantikan pameran secara fisik. Tulisan ini hendak membahas mengenai dampak pandemi Covid-19 terhadap para pelaku seni, serta bagaimana solusi yang dilakukan untuk menghadapi proses era New Normal. Tulisan ini mengeksplorasi beberapa pendekatan khususnya melalui media internet yang dapat dimanfaatkan para seniman untuk tetap dapat berkarya. Eksplorasi berbagai alternatif upaya berkesenian serta kolaborasi dibutuhkan guna kepentingan bersama untuk membangkitkan kembali dinamika seni rupa dengan memanfaatkan berbagai kebaruan dan teknologi. Kata kunci: Seni Rupa, Era New Normal, Residensi, Pameran Rupa Fisik, Teknologi. AbstractAlmost all fields of human activity, including fine arts, have been affected by the Covid-19 outbreak. Various alternative conducted to keep the industry running in the midst of a pandemic situation. Physical exhibitions and artist residencies must transform into technology-mediated art exhibitions and interactions. Various digital platforms then came to replace the physical art exhibition. This paper try to discuss the Covid-19 pandemic impacts and the alternative solutions to deal with the process of the New Normal era. This paper explores several approaches utilized by fine artists to continue their work, primarily through the internet media. Exploration of various artistic endeavors, as well as collaboration is needed for the common interest to revive the dynamics of art by utilizing various novelties and technologies. Keywords: Visual Arts, New Normal Era, Residency, Visual Arts Exhibition, Technology.
COVID-19 vaccine knowledge, attitudes, perceptions and uptake among healthcare workers of Pune district, Maharashtra
Authors: Bassi Shalini , Bahl Deepika , Thapliyal Nishibha , Maity Heeya , Marathe Saddicha Dilip , Prakshale Bhrunal Bajarang , Shah Vinod Gajanan , Salunke Subhash R. , Arora Monika 
Published: August 2022

Background Healthcare workers play a vital role in vaccine promotion and acceptance through community dialogue, education, and myth-busting. Vaccinated healthcare workers will likely recommend the vaccine to their families and community. Methods A cross-sectional study was conducted with healthcare workers (n=357) to understand their knowledge, attitudes, perceptions, and acceptance of the coronavirus disease 2019 (COVID-19) vaccine. The study was conducted in two blocks (Haveli and Velhe) of Pune, Maharashtra. Results The findings showed that over 90% of healthcare workers knew about COVID-19 vaccination and had a positive attitude towards COVID-19 vaccination. Among them, vaccine uptake was high (93% with two doses and 4% with a single dose). 98% of healthcare workers believed that vaccine is safe to use. However, few gaps existed around vaccine safety, side effects and allergic reactions, as 27.7% believed that the COVID-19 vaccine could increase the risk of allergic reactions, 51.8% believed that acquiring natural immunity by contacting the virus is better than vaccination, 16.5% believed that it is possible to reduce the incidence of COVID-19 without vaccination, 28.9% believed that vaccine might have side effects and 14% believed vaccine is not the most likely way to control the pandemic. Conclusions Addressing the existing gaps and reinforcing the relevance of the COVID-19 vaccine through a structured program is critical to empower health workers to disseminate accurate information to the community, consecutively improve vaccination uptake, and boost vaccination efforts in India.
PENERAPAN REWARD DAN PUNISHMENT DALAM MENINGKATKAN MOTIVASI DAN PRESTASI BELAJAR PENDIDIKAN AGAMA ISLAM SISWA DI SMKN 4 BONE
Authors: Waqiah Waqiah , Dj Muhammad Zuhri 
Published: August 2022

Abstract This thesis discusses how the application of reward and punishment in increasing motivation and learning achievement of Islamic religious education of students at SMK 4 Bone. This research is a qualitative research using three approaches namely the pedagogical approach, psychological approach and theological-normative approach. The data in this study were obtained through primary and secondary data namely observation and interviews directly to Islamic religious education teachers in the study site and also interviews directly to students in SMK 4 Bone by using research instruments in the form of observation guidelines, interview guidelines, documentation and analyzed with data reduction steps, data presentation and conclusion drawer. This study aims to determine the application of reward and punishment in SMK 4 Bone, To find out the forms of the application of reward and punishment in SMK 4 Bone, and to find out the implications of the application of reward and punishment in increasing student motivation and achievement at SMK 4 Bone Results of the research The process of applying rewards and punishments to improve student motivation and learning achievement at SMK 4 Bone, namely teachers and students make a deal that if students do their assignments well and excel will be rewarded. While students who do not do the work, disrupt the teaching and learning process, and do not obey the school rules, get punishment. As for the forms of rewards given to students such as gift giving, praise, body movements such as applause, thumbs up, etc. Whereas the Punishment given can be in the form of reprimands, additional tasks and body language / expressions (such as silence, looking away etc.).
Penanaman Pendidikan Multikultural dalam Mencegah Ekstrimisme pada Anak Usia Dini
Authors: Mauharir Muharir , Fauzi Fauzi , Mahfud Muntaha 
Published: August 2022

Terbentuknya manusia yang berkualitas diperlukan untuk pembangunan bangsa yang akan datang, salah satunya dengan penanaman pendidikan multikultural yang dimulai sejak usia dini, karena pendidikan menjadi sarana penting dalam membentuk kepribadi anak. Tujuan dari penelitan ini untuk mengetauai bagaiman PAUD Manahilul Funun dalam menanamkan pendidikan multikultural dalam mencegah ekstrimisma anak usia dini. Penelitian ini bersifat lapangan atau kualitatif. Teknik pengumpulan adalah observasi lapangan dan wawancara terstruktur kemudian dianalisis dengan menggunakan model penelitian Miles and Hubermant yaitu berupa data reduction, data display dan penarikan kesimpulan. Hasil dari penelitan ini: Pendidikan multikultural sejak usia dini dalam mencegah ekstrimisme dini di Manahilul Funun adalah sebagai berikut: penamana pendidikan komitmen kebangsaan, penamana pendidikan kebhinekaan toleransi, penamana pendidikan kemanusiaan, penamana pendidikan kearifan Lokal. Pengenalan pendidikan mulitikulturasime ini perlu ditanamkan pada PAUD dini agar generasi pemuda akan selalu teguh memegang nilai-nilai kebinikaan dan saling menghormati atara ras dan agama.
DESIGNING AN INVENTORY MODEL FOR THE BEHAVIOR OF DEPENDENCE ON LPG GAS CONSUMPTION OF 3 KG USING THE DYNAMIC SYSTEM SIMULATION METHOD IN LUWUK BANGGAI REGENCY
Authors: Aziz Izzul , Mail Abdul , Nusran Muhammad , Saleh Anis , Lantara Dirgahayu , Rauf Nurhayati , Fachry Muhammad 
Published: August 2022

Liquefied Petroleum Gas (LPG) or more commonly known as LPG gas is a gas stove fuel that comes from the results of liquefied petroleum gas and is then put into a tube, one of which is a 3-kilogram tube. The behavior of dependence on the consumption of 3-kilogram gas cylinders from the people of Banggai Regency can be seen from the use of non-subsidized 3 kilogram LPG gas, namely (±) 32. 002 people/group, the second is the consumption rate from subsidies and non-subsidies, namely 38. 864 units from total users, namely (±) 45. 000 people/groups with a supply of 30. 800 units and the third about frequent scarcity in 2020 and early 2021 reported by Banggai News and Obormotindok. Simulation Method Dynamic systems are modeling and running simulations of real systems to analyze problems and present solutions from policy scenarios from the researcher's perspective. By using this method, researchers can identify the behavior of 3 kilograms of gas consumption from the rate of consumption and demand through tables and graphs using the Powersim Studio 7 software. The results of the study present 3 policy scenarios, namely the first scenario regarding an increase in the transition to 99% non-subsidized gas cylinders with simulation results, namely September 1 2021 - October 1 2022 the demand is fulfilled, the second scenario regarding the addition of a 7th agent with simulation results, namely September 1 2021 - April 1 2023 demand can still be fulfilled and the third scenario regarding an increase in the transition to 99% non-subsidized gas cylinders and the addition of a 7th agent with simulation results, namely 1 September 2021 – 1 September 2023 the demand for needs is fulfilled. The conclusion is that the third policy scenario will be taken because among the policy scenarios presented, the preparation of tube supplies is fulfilled within two years, namely September 1 2021 - September 1 2023.
Coastal adaptations on the eastern seaboard of South Africa during the Pleistocene and Holocene? Current evidence and future perspectives from archaeology and marine geology
Authors: Will Manuel , Bader Gregor D. , Sommer Christian , Cooper Andrew , Green Andrew 
Published: August 2022

The use of marine resources and the settlement of coastal settlements may have influenced the bio-cultural evolution and dispersal of PleistoceneHomo sapiensin Africa. In order to test such scenarios, however, we require evidence for these behaviours deriving from an expanded spatio-temporal archaeological record. The Stone Age of South Africa documents the richest and longest record of coastal adaptations. In contrast to abundant evidence of coastal sites on the western and southern seaboard, the eastern Indian Ocean coast has not played a role in recent discussions. Considering the important and well-known Middle and Later Stone Age (MSA/LSA) record from inland sites of KwaZulu-Natal (KZN), this region may be an underappreciated area for further study. Here we provide a systematic overview of marine resource use and the settlement of coastal landscapes during the Late Pleistocene and Holocene in KZN. For the first time, we contextualize these archaeological findings with a review and new data on the changing marine and coastal geomorphology in the context of GIS modelling and offshore marine geophysical investigations. Our review finds evidence for long-term dietary and non-dietary use of marine resources during the MSA and LSA from a few stratified sites, with many more surface occurrences particularly for the MSA along the modern KZN coastline indicating human habitation. Comparisons to other areas of South Africa, GIS modelling and geological considerations suggest that current data on the eastern seaboard are not reflective of the original extent and nature of the consumption of marine foods and settlement of coastal landscapes. By contextualizing the biased and patchy MSA and LSA record with results on the dynamic marine and coastal geomorphology of KZN, we develop productive lines of future studies to assess open questions on potential coastal adaptations in this region. These research strategies include the identification of areas with high potential for finding new sites within a 10 km transect along the current coastline as well as dedicated off-shore projects including underwater archaeology aided by new marine geological work in the southwest Indian Ocean.
Lactate score predicts survival, immune cell infiltration and response to immunotherapy in breast cancer
Authors: Yin Ting-Ting , Huang Meng-Xing , Wang Fei , Jiang Yi-Hua , Long Jie , Li Liang , Cao Jie 
Published: August 2022

Background: Tumor-derived lactate can modulate the function of infiltrating immune cells to establish an immunosuppressive microenvironment that favors tumor progression. However, possible effects of lactate-related genes (LRGs) on the tumor microenvironment (TME) of breast cancer (BRCA) are still unknown.Methods: LRGs were comprehensively screened from lactate metabolism-related pathways. We correlated the expression of these LRGs with immune cell infiltrating characteristics in the TME and clinicopathological features of patients. We also established a lactate score for quantifying lactate metabolism patterns of cancers and to predict of recurrence-free survival (RFS).Results: We successfully constructed a lactate score that was an independent prognostic factor in BRCA. A low lactate score, which was associated with immune activation with increased CD8+ T cells infiltration levels, indicated an inflamed TME. Consistently, higher expression levels of inhibitory immune checkpoints, including PD-L1, LAG3, CTLA4, and TIM3, as observed from high lactate score subgroup, suggested an immune-desert phenotype as well as poor prognosis. Moreover, a low lactate score predicted the increased chemotherapeutic drug sensitivity and enhanced anti-PD-1 immunotherapy responses.Conclusion: The present study analyzed the potential roles of LRGs in the TME diversity and prognosis. These results will help to improve our understanding of the characteristics of TME immune cell infiltration and guide the development of more effective immunotherapy strategies.
Milk intake enhances cerebral antioxidant (glutathione) concentration in older adults: A randomized controlled intervention study
Authors: Choi In-Young , Taylor Matthew K. , Lee Phil , Alhayek Sibelle Alwatchi , Bechtel Misty , Hamilton-Reeves Jill , Spaeth Kendra , Adany Peter , Sullivan Debra K. 
Published: August 2022

BackgroundA major antioxidant, glutathione (GSH), is a key factor in the antioxidant defense mechanism against oxidative stress and aging-related functional declines. Our previous observational study showed positive correlations between brain GSH concentrations and dairy food consumption, particularly milk (p &lt; 0.001), in older adults.ObjectiveTo investigate whether a recommended amount of milk intake (3 cups/day) in low dairy consumers enhances brain GSH concentrations through an intervention trial.MethodsSeventy-three older adults (60–89 years) with a low dairy intake (≤1.5 servings/day) were randomized (5:2 ratio) in this 3-month randomized clinical trial. The intervention group was provided 1% milk weekly and instructed to consume 3 cups of milk/day for 3 months while the control group continued their habitual intake of total dairy ≤ 1.5 servings/day (&lt;1 cup of milk/day). Brain GSH concentrations were measured in the fronto-parietal region using our unique 3 T magnetic resonance chemical shift imaging technique at baseline and 3 months.ResultsAmong 73 randomized participants, 66 participants (49 intervention; 17 controls) completed the study. Milk intake in the intervention group increased from 0.2 ± 0.3 cups/day to 3.0 ± 0.6 cups/day (p &lt; 0.001) between baseline and the end of the study, while milk intake in the control group did not differ throughout the study duration (0.4 ± 0.4 cups/day). The intervention group showed increases in brain GSH concentrations by 7.4 ± 11.7% (p &lt; 0.001) in parietal and 4.7 ± 9.8% (p = 0.003) in fronto-parietal regions, and 4.6 ± 8.7% (p &lt; 0.001) in overall brain concentration after the intervention compared with baseline, while the control group showed no changes.ConclusionThis study provides evidence that milk serves as a good dietary source to increase and/or restore brain GSH concentrations in older adults. Identifying dietary sources that effectively enhance antioxidant defenses and neuroprotection could lead to the development of new strategies to promote brain health in the aging population.Clinical trial registration[https://ClinicalTrials.gov], identifier [NCT02957422].
Axillary management for early invasive breast cancer patients: Who will truly benefit?
Authors: Liu Yanbiao , Fan Yan , Jin Zining , Cui Mengyao , Yu Xinmiao , Jin Feng , Wang Xu 
Published: August 2022

BackgroundThe implementation of sentinel lymph node biopsy (SLNB) and further completion axillary lymph node dissection (cALND) after positive sentinel lymph nodes (SLNs) on early invasive breast cancer patients should be cautiously tailored. Identifying predictors for SLN and non-sentinel lymph node (nSLN) metastases can help surgeons make better surgical decisions.MethodsA retrospective case-control study was designed and a total of 560 eligible patients were enrolled consecutively. They were all diagnosed in our center and received appropriate medical care. According to the metastasis of SLN and nSLN, they were divided into metastatic and non-metastatic groups on two successive occasions to investigate the relationship between clinical factors, pathological factors, hematological factors and lymph node metastasis.ResultsIn total, 101 (18.04%) patients developed SLN metastases, including 98 patients with macro-metastases and 3 patients with micro-metastases. Out of 97 patients receiving further cALND, 20 patients (20.62%) developed nSLN metastases. Multivariate analysis revealed that “high expression of Ki-67” and “lymphatic invasion” predicted a higher risk of SLN metastasis; and “increased number of positive SLNs” and “increased systemic inflammation index (SII)” predicted a higher risk of nSLN metastasis.ConclusionSurgery for early invasive breast cancer patients should be more customized and precise. Appropriate axillary management is necessary for patients with the associated predictors.
Design of cylindrical metashells with piezoelectric materials and digital circuits for multi-modal vibration control
Authors: Yin Danjie , Yi Kaijun , Liu Zhiyuan , Zhang Anfu , Zhu Rui 
Published: August 2022

Thin-walled cylindrical shells are widely used in industries, such as the main parts of aircrafts, rockets, and submarines. Except for meeting the load-bearing capacities, such structures must also have good vibration and acoustic performances. However, it is still a challenge to control the multi-modal vibration of cylindrical shells at low frequencies. This study explores the cutting-edge local resonant piezoelectric metamaterials to control the low-frequency vibration of cylindrical shells. A novel cylindrical meta-shell with piezoelectric materials and digital circuits was proposed, and a multi-resonance transfer function is implemented in each digital circuit. A method to optimizing the parameters in the transfer function for the purpose of vibration reduction is developed. The vibrational characteristics of the meta-shell are numerically analyzed using the finite element method. Numerical results clearly demonstrate that by delicately designing the parameters in the transfer function, the meta-shell can reduce the peak amplitudes of the first five modes by 30 dB or more. Therefore, the proposed piezoelectric cylindrical meta-shell may open new opportunities in vibration mitigation of transport vehicles and underwater equipment.
Multi-tissue transcriptional changes and core circadian clock disruption following intensive care
Authors: Hollis Henry C. , Francis Julian N. , Anafi Ron C. 
Published: August 2022

Objective: Both critical illness and current care have been hypothesized to upset daily rhythms and impair molecular circadian function. However, the influence of critical illness on clock function in different tissues and on circadian output genes are unknown. Here we evaluate the effect of critical care and illness on transcription, focusing on the functional organization of the core circadian oscillator.Methods: We downloaded RNAseq count data from the Genotype-Tissue Expression (GTEx) project. Treating mechanical ventilation as a marker for intensive care, we stratified samples into acute death (AD) and intensive care (IC) groups based on the documented Hardy Death Scale. We restricted our analysis to the 25 tissues with &gt;50 samples in each group. Using the edgeR package and controlling for collection center, gender, and age, we identified transcripts differentially expressed between the AD and IC groups. Overrepresentation and enrichment methods were used to identify gene sets modulated by intensive care across tissues. For each tissue, we then calculated the delta clock correlation distance (ΔCCD), a comparative measure of the functional organization of the core circadian oscillator, in the both the AD and IC groups. The statistical significance of the ΔCCD was assessed by permutation, modifying a pre-existing R package to control for confounding variables.Results: Intensive care, as marked by ventilation, significantly modulated the expression of thousands of genes. Transcripts that were modulated in ≥75% of tissues were enriched for genes involved in mitochondrial energetics, cellular stress, metabolism, and notably circadian regulation. Transcripts that were more markedly affected, in ≥10 tissues, were enriched for inflammation, complement and immune pathways. Oscillator organization, as assessed by ΔCCD, was significantly reduced in the intensive care group in 11/25 tissues.Conclusion: Our findings support the hypothesis that patients in intensive care have impaired molecular circadian rhythms. Tissues involved in metabolism and energetics demonstrated the most marked changes in oscillator organization. In adipose tissue, there was a significant overlap between transcripts previously established to be modulated by sleep deprivation and fasting with those modulated by critical care. This work suggests that intensive care protocols that restore sleep/wake and nutritional rhythms may be of benefit.