bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-remission outcomes in AML patients with high hyperleukocytosis and inaugural life-threatening complications
Authors: Fodil Sofiane , Chevret Sylvie , Rouzaud Camille , Valade Sandrine , Rabian Florence , Mariotte Eric , Raffoux Emmanuel , Itzykson Raphael , Boissel Nicolas , Sébert Marie , Adès Lionel , Zafrani Lara , Azoulay Elie , Lengliné Etienne 
Published: July 2022

Introduction
Patients with hyperleukocytic (HL) acute myeloid leukemia (AML) are at higher risk of early death. Initial management of these patients is challenging, not fully codified and heterogenous. Retrospective studies showed that several symptomatic measures might decrease early death rate but long-term data are scarce. We aimed to analyze whether the therapeutic measures carried out urgently at diagnosis may influence the outcome among HL AML patients having achieved who survived inaugural complications.

Methods
We retrospectively reviewed all medical charts from patients admitted to Saint-Louis Hospital between January, 1st 1997 and December, 31st 2018 with newly diagnosed AML and white blood cell (WBC) count above 50x109/L. Outcome measures were cumulative incidence of relapse (CIR), treatment-related mortality (TRM) defined as relapse-free death, and overall survival. Univariate and multivariate analyses were performed using Cox proportional hazards models.

Results
A total of 184 patients with HL AML in complete remission (CR) were included in this study. At 2 years after CR. 62.5% of patients were alive, at 5 years, cumulated incidence of relapse was 55.8%. We found that every therapeutic measure, including life-sustaining therapies carried out in the initial phase of the disease, did not increase the relapse risk. The use of hydroxyurea for more than 4 days was associated with a higher risk of relapse. At the end of the study, 94 patients (51.1%) were still alive including 23 patients out of 44 aged less than 60 yo that were able to return to work.

Conclusion
We show that the use of emergency measures including life sustaining therapies does not come at the expense of a higher risk of relapse or mortality, except in the case of prolonged use of hydroxyurea. Patients with HL AML should be able to benefit from all available techniques, regardless of their initial severity.
Cilostazol effectiveness in reducing drug-coated stent restenosis in the superficial femoral artery: The ZERO study
Authors: Miura Takashi , Miyashita Yusuke , Hozawa Koji , Doijiri Tatsuki , Kato Tamon , Hayakawa Naoki , Hashizume Naoto , Nakano Masatsugu , Ikeda Uichi , Kuwahara Koichiro ,   on behalf of the ZERO Investigators
Published: July 2022

Purpose
Drug-eluting stents (DESs) play an important role in endovascular therapy (EVT) for femoropopliteal (FP) lesions. Cilostazol improves patency after bare-metal nitinol stent (BNS) implantation for femoropopliteal lesions. This study aimed to establish whether cilostazol is effective in improving the patency of DESs and determine whether BNS or DESs with or without cilostazol are more effective in improving the 12-month patency after EVT for FP lesions.

Materials and methods
In this prospective, open-label, multicenter study, 85 patients with symptomatic peripheral artery disease due to de novo FP lesions were enrolled and treated with DESs with cilostazol from eight cardiovascular centers between April 2018 and May 2019. They were compared with 255 patients from the DEBATE SFA study, in which patients were randomly assigned to the BNS, BNS with cilostazol, or DES groups. The primary endpoint was the 12-month patency rate using duplex ultrasound (peak systolic velocity ratio < 2.5). This study was approved by the ethics committee of each hospital.

Results
The 12-month patency rates for the BNS, BNS with cilostazol, DES, and DES with cilostazol groups were 77.6%, 93.1%, 82.8%, and 94.2%, respectively (p = 0.007). The 12-month patency rate was higher in the DES with cilostazol group than in the DES group (p = 0.044). In small vessels, the DES with cilostazol group had a higher patency rate than the DES group (100.0% vs. 83.4%, p = 0.023).

Conclusions
DES with cilostazol showed better patency than DES alone. Cilostazol improved patency after EVT with DES in FP lesions and small vessels.

Clinical trial registration
University Hospital Medical Information Network Clinical Trials Registry (no. UMIN 000032473).
Sleep quality and associated factors among adult hypertensive patients attending a chronic follow up care clinic in northwest Amhara regional state referral hospitals, Northwest Ethiopia
Authors: Ayanaw Teshale , Temesgen Mahlet , Azagew Abere Woretaw , Ferede Yohannes Mulu 
Published: July 2022

Introduction
Sleep plays an essential role in every individual’s life since it contributes greatly to their well-being and health. Poor sleep quality is one of the most common consequences of hypertension (HTN), which is a leading public health problem. In Ethiopia, it is the main health concern among hypertension patients. Thus, in the study area, there is limited information regarding the investigation of sleep quality among hypertension patients. Therefore, this study aimed to assess sleep quality and associated factors among adult hypertensive patients attending a chronic follow up care clinic in northwest Amhara regional state referral hospitals, Northwest Ethiopia.

Methods
An institution-based cross-sectional study was conducted among adult HTN patients from March 15/2021 to May 15/2021 in Northwest Amhara Regional State Referral Hospitals. A systematic random sampling method was used to select the study participants. A face-to-face interviewer-administered questionnaire with chart review was used. The Pittsburgh Sleep Quality Index (PSQI) for assessing sleep quality was used in this study. A binary logistic regression was used to see the association between dependent and independent variables. Variables having a p-value < 0.05 with a 95% CI were considered statistically significant in the multivariable logistic regression analysis.

Results
In this study, 563 hypertensive patients were included, with a response rate of 96.9%. The overall prevalence of poor sleep quality was 37.7% (95% CI: 33.4%–41.6%). Female gender (AOR = 2.55, 95% CI: 1.55–4.18), age ≥ 65 years (AOR = 4.07, 95% CI: 2.07–7.97), overweight (BMI) ≥ 25 kg/m2 (AOR = 1.68, 95% CI: 1.06–2.65), WHO stage II hypertension (AOR = 1.78, 95% CI:1.01–3.12), poor physical activity (AOR = 2.39, 95% CI:1.41–4.05), participants who had depression (AOR = 2.03,95% CI:1.24–3.34) and participants who had anxiety (AOR = 1.89, 95% CI: 1.16–3.03) were factors associated with poor sleep quality.

Conclusions
In this study, more than one-third of the study participants had poor sleep quality. Female gender, age ≥ 65 years, overweight (BMI) ≥ 25 kg/m2, stage II hypertension, physical inactivity, depression, and anxiety were all associated with poor sleep quality. Managing depression and anxiety disorders, encouraging physical activity, and providing health education about weight loss are all necessary for HTN patients.
Negative Aspects of Using the Concept of "Empire" to Determine the Geopolitical Nature of the Russian State
Authors: Nasyrov Rafail 
Published: July 2022

The purpose of the article is to reveal the negative aspects of using the term "empire" to characterize the Russian state and determine its geopolitical nature. The research is based on the achievements of a linguistic turn in socio-humanitarian studies, which have not yet been adequately taken into account in legal science. Leximes, as units of a particular language, do not simply denote certain phenomena of the surrounding world, but function as peculiar entities that determine the horizons of a native speaker, a particular picture of the world including value preferences and attitudes. It is recognized that in social communication don’t function abstract definitions, but rather concepts that predetermine the real content of discourse. Attention is drawn to the fact that in modern scientific and public discourse there is a process of revival of the term "empire" in the positive sense of the word. But the foreign term "empire" and the corresponding concept "empire" are not relevant to Russia, because they do not reflect the actual history of the emergence and formation of the Russian state. In the chronological framework of the New Age and Modern History, it is proposed to introduce a fundamental difference between colonial empires and territorial powers. On the one hand, it will be objective to say about the British and Russian empires that they used to have a vast territory with a populations that were diverse in ethnic, religious and cultural aspects. But, on the other hand, in form and essence, these were different territorial and political entities. In the course of deliberately obscuring this difference, a political myth was created about Russia as a "prison of peoples", which, unfortunately, was accepted by the majority of the domestic intelligentsia. In relation to the issue of ratio between the concepts of "empire" and "state" the conclusion has been made about the need to overcome the compiling-imitative style of Russia's development, which should be manifested in a more careful attitude to the development of a system of scientific and legislative terms that define the nature of Russian society and the state.
On the Definition of Doping and Сriminal Liability for its Use
Authors: Tydykova Nadezhda , Kovalenko Ekaterina 
Published: July 2022

The article covers the study of the concept of “doping” in Russian law and international acts. The importance of this issue for both domestic and international legislation is recognized. Both scientific and legislative definitions of the concept under study are given and analyzed. The authors come to the conclusion that the existing criticism of current definitions, as well as the constant development of technologies, require research to formulate new relevant concepts. Two corpora delicti have been studied, both of them established criminal liability for certain actions performed with substances and by means of methods prohibited for use in sports. Through criticism of the elements of these offenses, the authors prove that in order to form a correct and uniform practice of their application, it is necessary to make a number of changes to the studied offenses. The criticism of the elements of the object and the victim in the studied corpora delicti is analyzed. It is noted that the characteristics of the subject of these crimes pose difficulties for qualification due to the uncertainty of its characteristics. At present, it is possible to formulate specific proposals in regards to special subjects only in terms of probabilistic assumptions and recommendations, since there is no established judicial practice. It is also noted that the issue of differentiating criminal liability for the actions under study, depending on the presence or absence of qualifying factors is premature. A proposal was made to supplement one of the corpora with new qualifying factors. An assessment is made of the proposals of other authors on improving the dispositions of the studied norms, determining their place in the Criminal Code of the Russian Federation and supplementing the current Criminal Code of the Russian Federation with a new corpus delicti that encroaches on similar social relations.
Moins Trois
Authors: De Raedt Nele , Pytowski Yoel 
Published: July 2022

Résumé. Ce partage d'expérience à propos d'une installation artistique, réalisée de septembre à décembre 2021 dans le cadre de MAGMA la 10e Triennale d'art contemporain d'Ottignies–Louvain-la-Neuve, met en évidence plusieurs questions : Comment concilier dans un même projet artistique les finalités d'une chercheuse en architecture et d'un artiste visuel ? L'installation traduit-elle seulement des résultats de la recherche, ou possède-t-elle un rôle plus actif dans un projet, qui se définit comme recherche-création ? L'association de la recherche en architecture et de l'installation artistique génère-t-elle plutôt de nouvelles connaissances ou plutôt de nouvelles questions ?
Abstract. This shared experience in the creation of an art installation for MAGMA, the 10th Triennial of contemporary art of Ottignies-Louvain-la-Neuve, from September to December 2021, highlights several questions: How can the aims of a researcher in architecture and a visual artist be combined in one artistic project? Does the installation merely translate research results, or does it have a more active role in projects combining research with creation ? Does the combination of architectural research and artistic installation generate new knowledge, or rather new questions?
A (2 + 1)-dimensional variable-coefficients extension of the Date–Jimbo–Kashiwara–Miwa equation: Lie symmetry analysis, optimal system and exact solutions
Authors: Hu Yuru , Zhang Feng , Xin Xiangpeng , Liu Hanze 
Published: July 2022

Abstract
In this article, the Date–Jimbo–Kashiwara–Miwa equation is extended to a new variable-coefficients equation with respect to the time variable. The infinitesimal generators are acquired by studying the Lie symmetry analysis of the equation, and the optimal system of this equation is presented. After that, the equation performed similarity reductions, and the reduced partial differential equations (PDEs) are transformed into ordinary differential equations (ODEs) with the help of traveling wave transform. Then, the exact solutions are found by applying the extended tanh-function method. Finally, the structural features of exact solutions to different times are shown with the help of images.
Evaluation of appropriate vancomycin prescribing for the prevention of newborn group B streptococcal infections in a community hospital obstetrics service
Authors: Assabahi Amirah , Driggers Rita , Keeys Christopher A. , Mader Alexa , Norris Paul 
Published: July 2022

Abstract

Objectives
The 2019 American College of Obstetricians and Gynecologists (ACOG) guidelines update for the prevention of perinatal group B Streptococcus (GBS) infections stipulate that vancomycin should be reserved to treat penicillin-allergic women at high risk for anaphylaxis with documented GBS resistance to clindamycin. Protocols and policies were adapted at the community hospital to incorporate these new guidelines. The primary objective of this research was to evaluate institutional compliance to these guidelines and secondarily, clinical outcomes.

Methods
Clinical pharmacists, in collaboration with an obstetrician, performed this hospital-based study. All instances of intravenous (IV) vancomycin therapy in GBS-positive patients were assessed from 1/1/2018 through 1/1/2021 and compared to the 2010 and 2019 ACOG guidelines. Treatment was analyzed to determine the appropriateness of both indication for use and dosage regimen as co-primary endpoints. Secondary endpoints included renal monitoring parameters, suspected adverse reactions, and early onset GBS disease in newborns, specifically sepsis, meningitis, and/or pneumonia.

Results
L&D admissions during the study period included 15,129 patients. All 30 L&D patients who received IV vancomycin for GBS prophylaxis were included in the study. This project demonstrated low compliance to the ACOG guidelines and identified previously unrecognized opportunities for improvement.

Conclusions
The low compliance observed in this study, with the exception of documenting GBS status, occurred in spite of hospital adoption of a GBS order set, an updated vancomycin protocol and targeted education of clinical pharmacists. Assessment of the causes of noncompliance identified several potential corrective actions, especially in ordering and monitoring vancomycin.
Living with Absence, Missing Migrants and the Red Cross and Red Crescent’s Restoring Family Links Program
Authors: Secen Sefa , Shalaby Mostafa 
Published: July 2022

Abstract
The chaos and confusion that accompany war, disaster, and international migration separate families when they need each other most. The Red Cross and Red Crescent join the search across international borders, offering a unique service that allows families to reconnect. This paper examines the role of the Red Cross and Red Crescent, and specifically their Restoring Family Links (RFL) program in the search for missing migrants. Based on interviews with the RFL program’s officers and those individuals who have been reconnected with their missing family members, this paper evaluates the results and implications of the RFL program model, draws out lessons and insights (local, regional, or global), and makes policy recommendations. Also, by sharing migrants’ experiences and insights, it aims to raise awareness of the less well-known legal, economic, and social consequences of the displacement crises.
Temperature and duration of vernalization effect on the vegetative growth of garlic (Allium sativum L.) clones in Indonesia
Authors: Azmi Chotimatul , Rosliani Rini , Handayani Dwi Pangesti , Jayanti Hadis , Liferdi Liferdi , Palupi Endah R. 
Published: July 2022

Abstract
Garlic is usually propagated asexually from the cloves. Clove as the propagation source for garlic has many weaknesses. Alternatively, bulbils could be used for the propagation. The aim of this study was to know the effect of temperature and time of vernalization from several clones of Indonesian garlic to bulbil production. This research was conducted at a farmer’s field at Banjarnegara, Central Java, Indonesia. The experiment was arranged in a Completely Randomized Block Design with three factors: temperature of vernalization, i.e., 0, 5, and 10°C, duration of vernalization, i.e., 20, 40, and 60 days, and on 12 garlic varieties/clones (V1–V12). Cloves of garlic were vernalized in cold storage according to the treatments and then planted in the field. The results revealed that a temperature of 5°C and duration of 20 days of vernalization independently single factor increased the number of bulbils of V3. Bulbil variables of V4 and V7 were enhanced with vernalization at 0°C for 20 days, although it did not significantly differ from the control. Therefore, these clones do not need particular vernalization treatment in order to produce bulbils.
„Nach der Natur“: Schweizer Fotografie des 19. Jahrhunderts in einem kooperativen Ausstellungs- und Buchprojekt der Fotostiftung Schweiz
Authors: Manthey Stefanie 
Published: July 2022

Abstract
Die Fotostiftung Schweiz mit Sitz in Winterthur legte im Jubiläumsjahr 2021 in einem von ihr initiierten Projekt zur Fotografie des 19. Jahrhunderts in allen Landesteilen der Schweiz die Grundlagen für die zukünftige forschende, sammelnde, konservatorische und restauratorische Beschäftigung mit dem Medium. Mögliche Schwerpunkte sind die kritische Diskussion des Begriffs Fotografie und der Aufrechterhaltung ihrer Kartografie aus nationaler Perspektive sowie die Erweiterung ihrer Erforschung im europäischen Kontext.
Panel data models with two threshold variables
Authors: Lamadrid-Contreras Arturo , Ramírez-Rondán Nelson R. 
Published: July 2022

Abstract
We develop threshold estimation methods for panel data models with two threshold variables and individual fixed specific effects covering short time periods. In the static panel data model, we propose least squares estimation of the threshold and regression slopes using fixed effects transformations; while in the dynamic panel data model, we propose maximum likelihood estimation of the threshold and slope parameters using first difference transformations. In both models, we propose to estimate the threshold parameters sequentially. We apply the methods to a 15-year sample of 565 U.S. firms to test whether financial constraints affect investment decisions.
Pseudogapping in English: a direct interpretation approach
Authors: Kim Jong-Bok , Runner Jeffrey T. 
Published: July 2022

AbstractGapping elides a finite verb in the non-initial conjunct of a coordinate structure while VP ellipsis deletes a whole VP after an auxiliary. Unlike these two, pseudogapping elides most of the VP except one remnant. Pseudogapping additionally differs from gapping and VP ellipsis, in that it involves ellipsis of part of a non-finite VP. In this paper we provide a Construction Grammar account of pseudogapping that captures its similarities with as well as differences from other related elliptical constructions like VP ellipsis. Our construction-based analysis, which capitalizes on the inheritance network of constructions to capture broad similarities and unique differences among these constructions, allows us to account for the full range of extant data.
Design and Investigation of Dynamic Properties of the Developed Glass-Jute-CGS Fiber Reinforced Hybrid Epoxy Polymer Composites for High-Performance Applications
Authors: Arun K. , Mala D. , Gopalakannan S. , Prakash C. 
Published: July 2022

Abstract
In the current investigation, hybrid polymer composites developed using alkali treated Calotropis Gigantea stem fibers (CGS) as well as jute (J) and glass (G) fibers with different weight percentages are incorporated into the epoxy matrix. The dynamic characteristics for the inclusion of CGS fibers with glass-jute fiber reinforced epoxy-based laminates were determined experimentally. Here, three different sets of laminates, namely G-CGS-J-CGS-G, G-J-CGS-J-G, and G-CGS-CGS-CGS-G, were fabricated by means of the hand lay-up method. In addition, different weight percentages (wt. %) of CGS fibers, 0 wt. %, 5 wt. %, 10 wt. %, 15 wt. %, 20 wt. %, and 25 wt. %, were incorporated in the glass-jute fiber reinforced epoxy resin. The various analytical characterization results confirm that the incorporation of CGS fibers in the glass-jute fiber reinforced epoxy resin enhances the dynamic properties of the glass-jute fiber reinforced epoxy-based laminates, such as storage modulus, loss modulus, and tanδ values. The morphology of the fractured specimens due to the damage mechanisms was observed using a scanning electron microscope. Further, it was observed that the highest improvement in dynamic properties was achieved for the G-J-CGS-J-G hybrid laminate with 20 wt. % incorporated CGS fibers. The maximum storage modulus was observed in the G-J-CGS-J-G laminate of 8.263 Pa, with a loss modulus of 7.345 Pa and tanδ of 0.433 for 20 wt. % of CGS fibers. From the overall results, it was concluded that the hybrid laminate with 20 wt. % incorporated CGS fibers could be used for high-performance automobile interior applications.
A Comparative Study on the Oxidative Stability of Polycarbosilane-Based Cf/C–SiC and Cf/SiC Composites
Authors: Kamal Anurag , Painuly Anil , Prabhakaran Shyin Palani , Packirisamy S. 
Published: July 2022

Abstract
A carbon/carbon–silicon carbide (C/C–SiC) composite was prepared by first fabricating a C/C preform using carbon fiber and phenolic resin and subsequently densifying with a polymer precursor of SiC, viz., polycarbosilane (PCS). The C/SiC composite was realized by using PCS. These composites were machined and were subjected to oxidation resistance tests at 1,000°C and 1,500°C under a constant flow of air (6 slpm (standard litre per minute)) for a total duration of 60 min. The oxidation study was extended to the porous C/C preform and a commercially available dense C/C composite. The plot of mass loss versus time for all four types of composites indicates early saturation of mass loss for C/SiC, delayed saturation for C/C–SiC, whereas there was no saturation for C/C composites. The reasons for this behavior are analyzed using a scanning electron microscope equipped with an electron dispersive spectrometer, which reveal that the higher SiC content in C/SiC composite is responsible for self-sealing of the pores even at 1,500°C, whereas the lesser SiC content in C/C–SiC composite and C/C composites is unable to deliver the same results for the chosen set of experiments.