bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metastasis of breast cancer to the right kidney with a tumor thrombus in the inferior vena cava: a case report
Authors: Nagata Ayako , Shinden Yoshiaki , Nomoto Yuki , Saho Hazuki , Nakajo Akihiro , Minami Koji , Kumagae Yuichi , Kirishima Mari , Owaki Tetsuhiro , Ohtsuka Takao 
Published: January 2022

Abstract
Background
It is quite rare for breast cancer to metastasize to the kidney with a tumor thrombus in the inferior vena cava.

Case presentation
A Japanese woman in her forties was diagnosed with cancer of the left breast and underwent left mastectomy with sentinel lymph node biopsy. The final pathological diagnosis was pT1aN0M0, stage IA (ER positive, PgR positive, HER2 negative). Thirteen years later, she presented for care with the complaint of abdominal pain. By imaging findings, right renal carcinoma with a tumor thrombus in the inferior vena cava and lung metastases was suspected. However, her tumors were refractory to molecular targeted therapy. In addition, CT-guided needle biopsy of the kidney and lung lesions was done and it was revealed that lesions of the left lung and the right kidney was breast cancer metastases (ER positive, PgR positive, HER2 negative). The patient started combination therapy consisting of abemaciclib, tamoxifen and leuprorelin. Six months later, she died from progression of her metastatic disease.

Conclusions
It is sometimes difficult to differentiate between primary renal cancer and kidney metastases from breast cancer on imaging. Renal biopsy is recommended before commencing treatment.
The Effect of Load and Volume Autoregulation on Muscular Strength and Hypertrophy: A Systematic Review and Meta-Analysis
Authors: Hickmott Landyn M. , Chilibeck Philip D. , Shaw Keely A. , Butcher Scotty J. 
Published: January 2022

Abstract
Background
Autoregulation has emerged as a potentially beneficial resistance training paradigm to individualize and optimize programming; however, compared to standardized prescription, the effects of autoregulated load and volume prescription on muscular strength and hypertrophy adaptations are unclear. Our objective was to compare the effect of autoregulated load prescription (repetitions in reserve-based rating of perceived exertion and velocity-based training) to standardized load prescription (percentage-based training) on chronic one-repetition maximum (1RM) strength and cross-sectional area (CSA) hypertrophy adaptations in resistance-trained individuals. We also aimed to investigate the effect of volume autoregulation with velocity loss thresholds ≤ 25% compared to > 25% on 1RM strength and CSA hypertrophy.

Methods
This review was performed in accordance with the PRISMA guidelines. A systematic search of MEDLINE, Embase, Scopus, and SPORTDiscus was conducted. Mean differences (MD), 95% confidence intervals (CI), and standardized mean differences (SMD) were calculated. Sub-analyses were performed as applicable.

Results
Fifteen studies were included in the meta-analysis: six studies on load autoregulation and nine studies on volume autoregulation. No significant differences between autoregulated and standardized load prescription were demonstrated for 1RM strength (MD = 2.07, 95% CI – 0.32 to 4.46 kg, p = 0.09, SMD = 0.21). Velocity loss thresholds ≤ 25% demonstrated significantly greater 1RM strength (MD = 2.32, 95% CI 0.33 to 4.31 kg, p = 0.02, SMD = 0.23) and significantly lower CSA hypertrophy (MD = 0.61, 95% CI 0.05 to 1.16 cm2, p = 0.03, SMD = 0.28) than velocity loss thresholds > 25%. No significant differences between velocity loss thresholds > 25% and 20–25% were demonstrated for hypertrophy (MD = 0.36, 95% CI – 0.29 to 1.00 cm2, p = 0.28, SMD = 0.13); however, velocity loss thresholds > 25% demonstrated significantly greater hypertrophy compared to thresholds ≤ 20% (MD = 0.64, 95% CI 0.07 to 1.20 cm2, p = 0.03, SMD = 0.34).

Conclusions
Collectively, autoregulated and standardized load prescription produced similar improvements in strength. When sets and relative intensity were equated, velocity loss thresholds ≤ 25% were superior for promoting strength possibly by minimizing acute neuromuscular fatigue while maximizing chronic neuromuscular adaptations, whereas velocity loss thresholds > 20–25% were superior for promoting hypertrophy by accumulating greater relative volume.
Protocol Registration The original protocol was prospectively registered (CRD42021240506) with the PROSPERO (International Prospective Register of Systematic Reviews).
Initial coin offerings (ICOs): Why do they succeed?
Authors: Campino José , Brochado Ana , Rosa Álvaro 
Published: January 2022

AbstractRecent literature has addressed initial coin offering (ICO) projects, which are an innovative form of venture financing through cryptocurrencies using blockchain technology. Many features of ICOs remain unexplored, leaving much room for additional research, including the success factors of ICO projects. We investigate the success of ICO projects, with our main purpose being to identify factors that influence a project’s outcome. Following a literature review, from which several potential variables were collected, we used a database comprising 428 ICO projects in the banking/financial sector to regress several econometric models. We confirmed the impacts of several variables and obtained particularly valuable results concerning project and campaign variables. We confirmed the importance of a well-structured and informative whitepaper. The proximity to certain markets with high availability of financial and human capital is also an important determinant of the success of an ICO. We also confirm the strong dependency on cryptocurrency and the impact of cryptocurrency valuations on the success of a project. Furthermore, we confirm the importance of social media in ICO projects, as well as the importance of human capital characteristics. Our research contributes to the ICO literature by capturing most of the success factors previously identified and testing their impacts based on a large database. The current research contributes to the building of systems theory and signaling theory by adapting their frameworks to the ICO environment. Our results are also important for regulators, as ICOs are mainly unregulated and have vast future potential, and for investors, who can benefit from our analysis and use it in their due diligence.
How does CSR of food company affect customer loyalty in the context of COVID-19: a moderated mediation model
Authors: Zhang N. 
Published: January 2022

AbstractBecause of COVID-19 in the world, enterprises and consumers pay more and more attention to environmental protection, food safety and health issues. The purpose of this paper is to take China's food company as an example to study the impact of CSR on customer loyalty, mediating effects of company image and customer satisfaction, and moderating effects of COVID-19. The result shows that during COVID-19, company image and customer satisfaction have significant mediating effects, and COVID-19 positively moderate the impact of CSR on customer satisfaction.
Multiplexing modulation design optimization and quality evaluation of BDS-3 PPP service signal
Authors: Liu Cheng , Yao Zheng , Wang Dun , Gao Weiguang , Liu Tianxiong , Rao Yongnan , Li Dongjun , Su Chengeng 
Published: January 2022

AbstractThe Precise Point Positioning (PPP) service of BeiDou-3 Navigation Satellite System (BDS-3) is implemented on its Geostationary Earth Orbit (GEO) satellites. However, its signal design is limited by the actual power of satellite and other conditions. Furthermore, the design needs to fully consider the compatibility of different service phases. Starting from the actual state of the BDS-3 GEO satellite, this paper studies the multiplexing modulation of the BDS PPP service signal that is based on the Asymmetric Constant Envelope Binary Offset Carrier (ACE-BOC) technique and proposes several feasible schemes for this signal. Comparison and optimization of these techniques are made from the aspects of transmission efficiency, multiplexing efficiency, and service forward compatibility. Based on the Type-III ACE-BOC multiplexing modulation technique, phase rotation and intermodulation reconstruction techniques are proposed to suppress the intermodulation interference issue. Finally, a signal based on improved ACE-BOC multiplexing is designed. The quality of the proposed signal was continuously monitored and tested using large-diameter antennas. The evaluation results show that the power spectrum deviation of the signal is 0.228 dB, the correlation loss is 0.110 dB, the S-curve slope deviation is 1.558% on average, the average length difference between the positive/negative chip and the ideal chip is only 0.0006 ns, and the coherence between the carrier and the pseudo code is 0.082°. All quality indicators are satisfactory, indicating that the proposed signal multiplexing modulation technique is an ideal solution that meets all the requirements of the design constraints, and can achieve efficient information broadcasting and forward compatibility of the BDS PPP service.
Combined surgical and intraoperative endoscopic rescue of a biliary incarcerated balloon dilator: a successful rescue in a fortunate patient
Authors: Alhaddad Omkolsoum , Elsabaawy Maha , Kamal Ahmed , Edrees Ahmed , Mansour Tarek 
Published: January 2022

Abstract
Background
Endoscopic papillary balloon dilatation (EPBD) is the second proposed maneuver for the endoscopic retrieval of common bile duct stones after endoscopic sphincterotomy (EST). Being less traumatic, EPBD is acknowledged for fewer procedure-related complications compared to (EST).

Case presentation
We present a 55-year-old lady, who was referred to the pancreato-biliary division, Gastrointestinal Endoscopy Unit, National Liver Institute, Menoufia University, for endoscopic management of a high likelihood of choledocholithiasis. Unfortunately, during the procedure, the balloon dilator was incarcerated inside the common bile duct (CBD) with failure of all endoscopic extraction trials. Because of the resultant cholangio-pancreatitis, the incarcerated inflated balloon had to be removed immediately. Open surgical rescue of the case in conjunction with the intraoperative endoscopic biliary stent deployment had made it possible to save the patient.

Conclusion
This case is one of the few reports of incarcerated balloon dilator during EPBD and failure of endoscopic retrieval, with subsequent acute pancreatitis/hepato-cholangitis, and gall bladder mucocele. Despite being a critical surgical candidate and owing to the attentive timely surgical intervention collaborated with the intra-operative endoscopic management, the case was fortunate.
A feasibility study of training in a local community aimed upon health promotion with special emphasis on musculoskeletal health effects
Authors: Prawiradilaga Rizky Suganda , Bendtsen Magnus , Esrup Simon , Jørgensen Niklas Rye , Yulianto Fajar Awalia , Helge Eva Wulff 
Published: January 2022

Background: To minimize fracture risk, multimodal training regimens are recommended. However, their effectiveness in community settings remains uncertain. This study evaluated the feasibility of 19-weeks of multimodal training in a local community center with emphasis on musculoskeletal health in postmenopausal women. Methods: In a controlled trial, 28 postmenopausal women (53-68-years-old) were assigned to a multimodal training group (MMT, n=15) or a control group (CON, n=13). The training consisted of high- and odd-impact, resistance and balance-coordination training 1-2 hours weekly. The outcomes were attendance rate, regional and total bone mineral density (BMD), bone mineral content (BMC), bone turnover markers (BTM), body composition, functional muscle strength and power, and dynamic balance. All were determined at baseline and after 19 weeks of training. BTM was assessed after three weeks. Results: Overall, 22(79%) participants (MMT, n=9; CON, n=13) completed the study, and the mean attendance rate for MMT was 65.5% of the maximum sessions (2) offered. Only right trochanter BMD increased (p<0.05) by 1.0±1.1% in MMT, which was higher(p<0.05) than CON. While whole-body BMC was not changed at 19 weeks from baseline in MMT, it decreased (p<0.05) in CON resulting in a significant difference (p<0.05) in whole-body BMC delta values between the two groups. Compared to baseline, body fat percentage(%BF), fat mass(FM), and visceral adipose tissue (VAT)-mass and -volume were decreased (p<0.01) in MMT, and were larger (p<0.05) than CON. No significant changes were observed in BTM, muscle strength and power, and dynamic balance after 19 weeks. Conclusions: Nineteen weeks of multimodal training 1-2 hours per week in a local community had a health-enhancing effect on %BF, FM, and VAT, whereas the musculoskeletal health impact was modest. We hypothesize that the reason might be too low training volume and frequency and supposedly too low musculoskeletal training intensity for some participants. Registration: ClinicalTrials.gov NCT05164679 (21/12/2021).
Relationships between geomagnetic Ар-indeх and parameters of the acupuncture points as well as neuroendocrine-immune complex in patients with its dysfunction
Authors: Tserkovniuk R. , Gozhenko A. , Korolyshyn T. , Kovbasnyuk M. , Hubyts’kyi V. , Kikhtan V. , Fil V. , Anchev A. , Zukow W. , Yanchij R. , Popovych I. 
Published: January 2022

Background. Back in 1990, YuP Limansky hypothesized acupuncture points (AP) as polymodal receptors of the ecoceptive sensitivity system. In the process of hypothesis development in 2003 an existence of separate functional system of regulation of electromagnetic balance of organism has been substantiated and a working conception of light therapy has been formulated. In line with this hypothesis, we set out to analyze the relationships between the disturbances of the geomagnetic field (Ap-index) and the electrical conductivity of a number of AP, on the one hand, and the parameters of the neuroendocrine-immune complex in patients with its dysfunction, on the other. Material and methods. The object of observation were 21 men (24-63 y) and 20 women (30-72 y) with neuroendocrine-immune complex dysfunction. Each patient was tested twice with an interval of 4 days. Retrospectively we recorded the geomagnetic Ap-Index on the day of testing and during the previous 7 days, using resource https://www.spaceweatherlive.com/. Recorded the electrical conductivity of 9 pairs of AP, electroencephalogram (EEG) and heart rate variability (HRV) parameters, determined the plasma level of cortisol, triiodothyronine and testosterone, the content of lymphocytes expressing CD3, CD4, CD25, CD8, CD22 and CD56 receptors, the serum level of circulating immune complexes, immunoglobulins classes M, G, A as well as C-reactive protein, IL-1β and IL-6. The state of phagocytic function of neutrophils estimated by microbial count and phagocytic and killing indices against Staphylococcus aureus and Escherichia coli. Results. During the week, the average level of Ap-index ranged from 7 to 13 nT. Maximum coefficients of multiple correlation with APs parameters were detected for Ap-index on 6 day before (R=0,552) and on the day of testing (R=0,470), with EEG parameters on the eve of registration (R=0,708) and on 6 day before its (R=0,685), with immunity parameters on the eve of blood sampling (R=0,768) and on 5 day before its (R=0,758), with HRV&Hormonal parameters on 2 (R=0,506) and 7 (R=0,403) days before testing. The canonical correlation between Ap-indices for 7 days before and on the day of testing, and the parameters APs is 0,661; EEG parameters is 0,886; HRV&Hormonal parameters is 0,766 and immunity parameters is 0,921. APs parameter are closely related to the EEG (R=0,997) and HRV&Hormonal parameters (R=0,740). In turn, the immune parameters are closely related to the EEG (R=0,944) and HRV&Hormonal parameters (R=0,714). Conclusion. Disturbances of the geomagnetic field (Ap-index) causes a significant immediate modulating effect on the parameters of neuroendocrine-immune complex, apparently through acupuncture points as polymodal receptors of the ecoceptive sensitivity system.
The safe resumption of elective orthopaedic services following the first wave of the COVID-19 pandemic
Authors: Asopa Vipin , Sagi Amit , Bishi Habeeb , Getachew Fanuelle , Afzal Irrum , Vyrides Yiannis , Sochart David , Patel Vipul , Kader Deiary 
Published: January 2022

Aims There is little published on the outcomes after restarting elective orthopaedic procedures following cessation of surgery due to the COVID-19 pandemic. During the pandemic, the reported perioperative mortality in patients who acquired SARS-CoV-2 infection while undergoing elective orthopaedic surgery was 18% to 20%. The aim of this study is to report the surgical outcomes, complications, and risk of developing COVID-19 in 2,316 consecutive patients who underwent elective orthopaedic surgery in the latter part of 2020 and comparing it to the same, pre-pandemic, period in 2019. Methods A retrospective service evaluation of patients who underwent elective surgical procedures between 16 June 2020 and 12 December 2020 was undertaken. The number and type of cases, demographic details, American society of Anesthesiologists (ASA) grade, BMI, 30-day readmission rates, mortality, and complications at one- and six-week intervals were obtained and compared with patients who underwent surgery during the same six-month period in 2019. Results A total of 2,316 patients underwent surgery in 2020 compared to 2,552 in the same period in 2019. There were no statistical differences in sex distribution, BMI, or ASA grade. The 30-day readmission rate and six-week validated complication rates were significantly lower for the 2020 patients compared to those in 2019 (p < 0.05). No deaths were reported at 30 days in the 2020 group as opposed to three in the 2019 group (p < 0.05). In 2020 one patient developed COVID-19 symptoms five days following foot and ankle surgery. This was possibly due to a family contact immediately following discharge from hospital, and the patient subsequently made a full recovery. Conclusion Elective surgery was safely resumed following the cessation of operating during the COVID-19 pandemic in 2020. Strict adherence to protocols resulted in 2,316 elective surgical procedures being performed with lower complications, readmissions, and mortality compared to 2019. Furthermore, only one patient developed COVID-19 with no evidence that this was a direct result of undergoing surgery. Level of evidence: III Cite this article: Bone Jt Open 2022;3(1):42–53.
Cultural Factors, Migrant Status, and Vulnerability to Increasing Temperatures among Hispanic/Latino Farmworkers: A Systematic Review
Authors: Berumen-Flucker Brenda , Kekeh Michele , Akpinar-Elci Muge 
Published: January 2022

HighlightsCultural factors and acculturative stressors affect the health and safety behaviors of Hispanic/Latino farmworkers.Cultural factors and stressors also increase their risk of heat-related illnesses (HRIs).Interventions targeting HRIs in this population should account for cultural factors.Abstract. Hispanic/Latino farmworkers have been widely recognized as a particularly vulnerable population in the U.S., with among the lowest levels of income and education in the country. Existing research has identified and explored factors, including cultural and demographic characteristics, that increase the vulnerability of these workers to adverse occupational health and safety outcomes. This review assesses Hispanic/Latino farmworkers’ vulnerability to increasing temperatures and intense heat events, focusing on the role of demographic and cultural factors in heat-related health outcomes. A systematic literature search was conducted using the search terms “heat” and “(Hispanic or Latino) farmworkers” and “health” over the years 2000 to 2020. A total of 348 articles were screened through a title review. The articles included in this review focused on heat-related illnesses (HRIs) and related symptoms among the population of interest. Hispanic/Latino workers were at heightened risk of HRI symptoms as a result of their work environments, working conditions, acculturative stressors, and other cultural factors. Keywords: Farmworkers, Heat-related illness, Hispanic, Latino.
Situs Makam Gunungpring (Studi Tentang Peran Kyai Raden Santri Terhadap Islamisasi di Magelang, Jawa Tengah (1660-1810 M).
Authors: Qowiyyudin Adib Abbiya 
Published: January 2022

Gunungpring is an area located in Muntilan Magelang, Magelang Regency. there are several tombs of religious leaders of the Mataram Sultanate, one of the figures is Kyai Raden Santri. Kyai Raden Santri is a descendant of Brabu Brawijaya V and brother of one of the first Mataram Sultanate Panembahan Senopati. Kyai Raden Santri is one of the religious, social and cultural figures of the people of Muntilan and surrounding areas who is able to make a significant contribution in the region. Have a religious ability that is high enough so that it can attract the attention of the public to get to know the religion of Islam in various ways ranging from simple to developing the existing potential. Kyai Raden Santri's grave and complex areas were developed in stages through various ways, one of which was the donation of funds from the community and direct assistance from the Yogyakarta Palace to become a religious tourism destination for both local and national communities and develop the potential to provide good facilities to visitors who would visit the tomb Kyai Raden Santri and other tombs in the complex. The approach used in this research is the architecture and sociology approach. The architecture approach is used by researchers to explain the art of building the tomb of Kyai Raden Santri. While the sociological approach is used by researchers to determine role of the Kyai Raden Santri clerics in the spread of Islam in the Muntilan Magelang region.[Gunungpring merupakan sebuah kawasan yang terletak di Muntilan Magelang, Kabupaten Magelang. Ada beberapa makam tokoh agama Kesultanan Mataram, salah satunya adalah Kyai Raden Santri. Kyai Raden Santri adalah keturunan Brabu Brawijaya V dan saudara dari salah satu Kesultanan Mataram pertama Panembahan Senopati. Kyai Raden Santri merupakan salah satu tokoh agama, sosial dan budaya masyarakat Muntilan dan sekitarnya yang mampu memberikan kontribusi yang cukup berarti di daerah. Memiliki kemampuan beragama yang cukup tinggi sehingga dapat menarik perhatian masyarakat untuk lebih mengenal agama islam dengan berbagai cara mulai dari yang sederhana hingga mengembangkan potensi yang ada. Kawasan Makam dan Kompleks Makam Kyai Raden Santri dikembangkan secara bertahap melalui berbagai cara, salah satunya adalah dengan sumbangan dana dari masyarakat dan bantuan langsung dari Keraton Yogyakarta untuk menjadi destinasi wisata religi baik bagi masyarakat lokal maupun nasional serta mengembangkan potensi yang dimiliki. memberikan fasilitas yang baik kepada pengunjung yang akan mengunjungi Makam Kyai Raden Santri dan Makam lainnya yang ada di dalam kompleks. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan arsitektur dan sosiologi. Pendekatan arsitektur yang digunakan peneliti untuk menjelaskan seni membangun makam Kyai Raden Santri. Sedangkan pendekatan sosiologis digunakan peneliti untuk mengetahui peran ulama Kyai Raden Santri dalam penyebaran agama Islam di wilayah Muntilan Magelang.]