bluuebunny/crossref_metadata_2025_split huggingface dataset:
Butyrate Attenuated Lithium-Induced Cardiometabolic Disorders Through Enhanced PI3K/eNOS Independent of Adenosine Deaminase in Male Wistar Rats
Authors: Oyabambi Adewumi Oluwafemi , Bamidele Olubayode , Boluwatife Aindero Blessing 
Published: June 2022

Abstract
Background
Cardiometabolic disease is becoming a main cause of death worldwide with over ten million fatalities annually. Lithium (Li), a known therapy for bipolar disorders is now evolving as a major cause of various cardiometabolic disorders and sodium butyrate (NaB) which is a short chain fatty acid and gut microbiota has been identified to possess an amazing therapeutic effect against cardiometabolic disorders. As a result, the current study aims to evaluate sodium butyrate impact on lithium-induced cardiometabolic disorders.
Methods
Twenty male Wistar rats weighing between 125-130g were used for the experiment. They were grouped into Control and treated groups respectively as (CTR; normal chow), Lithium only (Li; 5mg/kg), Sodium butyrate only (NaB) (200mg/kg) and NaB + Lithium (Li; 5mg/kg + NaB; 200mg/kg) for six weeks, after a week of acclimatization; n = 5. The animals were euthanized with 0.2ml of ketamine hydrochloride, blood samples were collected and cardiac tissue homogenates were measured for plasma Fasting Blood Glucose (FBG), insulin, phosphatidylinositol 3 Kinase (PIK3), Nitric oxide (NO), Glucose-6-phosphate dehydrogenase (G6PDH), malonyladehyde (MDA), Catalase, Sodium Dismutase (SOD), NADPH, Glutathione Peroxidase (GPx), and Adenosine deaminase /xanthine oxidase /uric acid (ADA/XO/UA) using standard spectrophotometric method.
Results
The results showed that lithium significantly increased fasting blood sugar (FBS), GPx, catalase, SOD, and malonyladehyde (MDA) (P < 0.05) while causing a statistical reduction in plasma insulin, plasma and cardiac concentration of NADP+, G6PDH, PI3K, endothelial nitric oxide synthase (eNOS), and Nitric Oxide (NO) in comparison with the control. However, butyrate attenuated plasma GPx, catalase, SOD, MDA and significantly elevated plasma and cardiac PI3K, eNOS, NO, FBS, plasma insulin, plasma NADPH+ and G6PDH levels in relation to control. Also no change was observed in the plasma and cardiac ADA/XO/UA following sodium butyrate.
Conclusion
Therefore, butyrate has a remarkable therapeutic potential in lithium induced cardiometabolic disorders through vascular regeneration and glucometabolic control.
TIMP1, a promising target of tumor development diagnosis and treatment for colorectal cancer
Authors: Wen Hang , Chen Yan , Fu Zhenjie , Lv Hang , Chen Yitao , Lin Meiai 
Published: June 2022

Abstract
Background: Colorectal cancer is one of the most common malignancies globally, causing a tremendous social burden. Revealing causes and underlying molecular mechanisms and discovering molecular biomarkers for early diagnosis, prevention, and personalized treatment is critical.Methods: To identify the candidate genes in cancer progression, three microarray datasets were downloaded from the GEO database. GEO2R identified the differentially expressed genes (DEGs), and DAVID performed functional enrichment analyses. The protein-protein interaction network was constructed, and hub gene selection was performed using STRING. GEPIA2 was used to explore the expression level change of 10 hub genes and perform the prognosis corresponding information. RT-qPCR and immunoblotting were performed to verify the expression level of TIMP1 in clinical tissues. Results: A total of 223 DEGs were identified. The enrichment analysis results showed that the functions of the differentially expressed genes were mainly concentrated in ion transport, protein degradation, mineral absorption, and cancer processes. In the PPI network, ten genes were identified as hub genes. Compared with normal tissues, the rest of the genes were significantly overexpressed apart from CXCL12. Survival analysis showed that TIMP1 was significantly correlated with the poor prognosis of CRC patients. RT-qPCR and immunoblotting showed TIMP1 up-regulated considerably in CRC tissues. Conclusions: In conclusion, for colorectal cancer, combined with the functional characteristics and the current statistical analysis results, TIMP1 is a very promising target for diagnosis and treatment.
Mechanism of Erzhiwan in treating osteoporosis based on molecular docking technology and molecular dynamics simulation
Authors: Li Yanling , Li Ziliang , Ye Tongsheng , Hao Fuqi , Wang Yichi , Li Wenqian , Yan Qingfeng , Shi Huawei , Han Weijuan 
Published: June 2022

Abstract
This experiment was a network pharmacology research based on the theoretical system of traditional Chinese medicine. TCMSP database, PubChem database, RCSB database and SwissTargetPrediction database were used to study the effective chemical constituents of Ligustri lucidi Fructus and Ecliptae Herba in Erzhiwan, a traditional prescription for nourishing liver and kidney. Then using Genecards database, OMIM database, OMIM Gene Map and Metascape database to study the therapeutic targets of Osteoporosis. At last, using Cytoscape 3.6.0 software, its built-in Bisogenet and CytoNCA, AutoDockTools-1.5.6 software, PYMOL-2.2.0 software and Gromacs software, by drawing the relationship diagram between chemical components and disease targets, PPI network of disease, semi-flexible molecular docking technology, evaluation and analysis of enrichment pathway, molecular dynamics simulation, to study the therapeutic mechanism of Erzhiwan on osteoporosis. It is found that the intervention and regulation of Erzhiwan on osteoporosis were mainly realized through multiple targets of active ingredients and multiple pathways, which provided support for the continued development of Erzhiwan.
Same-Day Thyroidectomy Outcomes: A Canadian Multi-Center Retrospective Cohort Study
Authors: Fortin Mélyssa , Noik Maxine , Hudson Thomas J. , Silva Sabrina D. da , Forest Véronique-Isabelle , Hier Michael P. , Mlynarek Alex M. , Payne Richard J. 
Published: June 2022

Abstract
Background
The American Thyroid Association supports same-day thyroid surgery (SDT) in select patients. In practice, it is common for thyroid surgeons to monitor patients overnight for postoperative complications such as cervical hematoma, recurrent laryngeal nerve injury (RLN) and symptomatic hypocalcemia. We sought to determine the safety profile and predictive factors of adverse postoperative outcomes for SDT based on the experience of three large institutions.
Methods
A retrospective cohort study was conducted for all thyroidectomies performed at three McGill University tertiary and quaternary care centers in Montreal, Canada between January 1st, 2016 and November 13th, 2020. Patient characteristics were associated with outcomes by bivariate and multivariate analyses.
Results
A total of 2297 records were surveyed and 1983 patients (1513 females, 470 males) met the inclusion criteria. Amongst them, 603 (30.4%) patients were discharged the same day. The overall postoperative complication rate amongst SDT was 3.6% compared with 10.7% for inpatients (p < 0.0001). Cervical hematoma was not observed in the SDT group, whereas 8 inpatients (0.6%) developed this complication (p = 0.061). RLN injury occurred in 7 SDT (1.2%), compared with 35 (2.5%) inpatients (p = 0.050). Symptomatic hypocalcemia occurred in 3 SDT (0.5%) compared with 73 (5.3%) inpatients (p < 0.0001). 36 (6%) 30-day Emergency department (ED) visits were noted for SDT compared to 172 (12.5%) for inpatients (p < 0.0001), and none required readmission or reoperation within that postoperative period. In the multivariate logistic regression analysis, SDT patients were less associated with comorbidities and had a lesser risk to develop symptomatic hypocalcemia (p < 0.0001). SDT patients had lower 30-day ED (p = 0.041) and reoperation (p = 0.037) rates compared with the inpatient group.
Conclusion
This study demonstrates that SDT are safe in a select group of patients under the care of experienced thyroid surgeons at high volume thyroid surgery centers. SDT can also lead to significant cost savings in a publicly funded health care system. Further exploration is needed to clarify patient profiles most amenable to SDT and inform clinical decision-making.
Time and Error Analysis of Neural Network Model of Rectangular Vibrating Membrane
Authors: Pandey Vikas Kumar , Agarwal Himanshu , Aggarwal Amrish Kumar 
Published: June 2022

Abstract
Series solution of rectangular vibrating membrane (SSRVM) of the motion has been represented by Neural Network (NN) model. Experiments have been performed to find a combination of NN structure and size of sample data such that error and time cost of SSRVM are the minimum. Error and time cost of NN models have been studied w.r.t structure, size of sample, random choice of initial weights and selection of data. Peak signal to noise ratio (PSNR) between series solution and solution by NN model is approximately 50 dB. This ensures that solution obtained by NN model is acceptable at human visual system. The average training time of constructed NN models is better than state-of-the-art related to solution of differential equation by NN. NN models are 26 times faster than SSRVM for solution prediction.
OF Spine classification without CT Examination- does it work?
Authors: Spiegl Ulrich J. , Behr Lars , Osterhoff Georg , Rupprecht Gunnar , Scheyerer Max J. , Katscher Sebastian 
Published: June 2022

Abstract
Objectives: The purpose of this study was to investigate whether the addition of computed tomography (CT) to magnetic resonance imaging (MRI) improves the accuracy of classifying osteoporotic vertebral body fractures (OVBF). Methods: A retrospective analysis of a prospective single-center database has been performed. All consecutive patients who had suffered an acute thoracolumbar OVBF in one level II spine center between 2017 and 2019 were analyzed. All fractures were initially classified by 5 board-certified orthopaedic surgeons based on MRI and conventional radiographs. Afterwards a reclassification including CT scans were performed. Differences in OF classification and OF score values between both measurements were analyzed.Results: A total of 61 patients were analyzed with a mean age 75.8 years (SD: 8.8 years). In 82.9% of the cases, there was no difference in OF classification comparing classification based only on MRI versus MRI+CT. A difference of more than two OF types was observed in less than 1% of all ratings. The inter-rater reliabilities of the OF classification based on CT+MRI and MRI alone were 0.63 and 0.49, respectively. In 97.5% of the cases there was no therapy-relevant difference of the treatment recommendation with respect of a surgical or nonoperative treatment recommendation based on the OF score.Conclusion: In terms of the OF classification and the OF score, the addition of CT add limited value compared to conventional radiographs and MRI only. Additionally, there is only a minor rate of disagreement in treatment recommendations as by the OF score when adding a CT.
Secondary Hyperparathyroidism in Adult Chronic Hemodialysis Patients: Prevalence and Clinical Aspect
Authors: Bashir Ahmed Muhammad , Alici Gokhan , Wabari Mohamud Mire , Adani Abdulkamil Abdullahi 
Published: June 2022

Abstract
Background: Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD). Aim: The exact prevalence of secondary hyperparathyroidism in chronic hemodialysis patients in Somalia is unknown. In this study, we aimed to determine the prevalence of SHPT in chronic hemodialysis patients in Mogadishu, Somalia.Method: This retrospective analysis was carried out at the Mogadishu Somali Turkey Training and Research Hospital, Somalia’s largest dialysis center. All hemodialysis patients aged 18 years and older from the last year were included. The research excluded parathyroidectomy patients and patients on steroids, phenytoin, or phenobarbitone. This analysis covered 195 patients. Calcium, phosphate, albumin, vitamin D, urea, creatinine, and other electrolytes were tested.Results: The mean age of the 195 patients was 56.0±17.4, with 49.2% males and 50.88% females. End-stage kidney disease (ESKD) was caused by hypertension in 64.1% of the patients and diabetes in 30.8%. The mean hemodialysis time was 7.8±1.3 hours per week, and the mean duration was 39.6±15 months. The mean intact parathyroid hormone (iPTH) concentration was 458.59±636.96 pg/mL, phosphate was 4.24±2.15 mg/dL, corrected calcium was 8.70±0.97 mg/dL, and calcium phosphate product was 36.60±19.78 mg/dL. The mean vitamin D concentration was 33.53±19.70. We found that the prevalence of secondary hyperparathyroidism was 65.6%.Conclusion: We conclude that there is a high prevalence of secondary hyperparathyroidism in chronic hemodialysis patients in Somalia and that measures that predict vitamin D response, including sestamibi parathyroid scans and gland volume, should be studied further to prevent this high prevalence.
Structure design and experimental study on ultrasonic vibration-assisted induction brazing cubic boron nitride abrasive tools
Authors: Cai Kaida , Zhao Biao , Wu Bangfu , Ding Wenfeng , Zhao Yanjun , Zhu Jianhui , Si Wenyuan 
Published: June 2022

Abstract
Brazed abrasive tool has been widely used in high-precision machining of difficult-to-cut materials to improve the machining efficiency and quality. However, the severe wear and associated short service life during machining processes have to be faced for conventional induction brazed (CIB) abrasive tools owing to its weak bonding strength between abrasive grains and metal-bonded materials. In this case, a novel ultrasonic vibration-assisted induction brazing (UVAIB) device was developed to improve the abrasive bonding strength. Here, the frequency equation of the UVAIB device was derived using recursive methods, and then the geometric designation parameters were optimized with the finite element simulating method. In addition, the performance of UVAIB device was tested in terms of the impedance and amplitude. Subsequently, the comparative experiment trials were performed with the brazed abrasive tools under the CIB and UVAIB method. Results show that the ultrasonic energy loss of UVAIB device could be reduced, and then the amplification value and vibration uniformity could reach 8 and 92%, respectively. In addition, for CIB, there are a large number of pores and macro-cracks on the joints. However, the internal pores inside the metallic matrix of UVAIB were reduced, and only fewer and smaller micro-cracks could be found. Furthermore, the intergranular fracture of abrasive grains could be observed for CIB abrasive tools owing to the weak bonding interface caused by the existence of numerous micropores, whereas the grain transgranular fracture appeared once adopting the ultrasonic vibrating method.
Improving power efficiency in 6G wireless communication networks through reconfigurable intelligent surfaces for different phase information
Authors: Rad Amin Mahmoudi , Pourrostam Jafar , Tinati Mohammad Ali 
Published: June 2022

Abstract
With increasing needs for high-bitrate, ultra-reliability, spectral efficiency, power efficiency, and reducing latency in the wireless network, global studies on the sixth generation of this network began in 2020. In this paper, we will look at intelligent reconfigurable surface structure and its application in new promising physical layer technologies, such as terahertz communications and UM-MIMO systems, to support very high bitrate and superior network capacity in the 6G wireless communications. Although, terahertz communications and UM-MIMO systems are the primary research points and confront many challenges for practical implementation. They require many RF chains and create problems in terms of cost and hardware complexity which RIS can simplify hardware and reduce cost. Therefore, we will present different modeling of wireless communication systems based on RIS for different phase information. Simulation results obtained by examining SNR performance and the error probability that shows the improvement of the received signal quality. According to results, RIS-based wireless communications can become an optimized model for future wireless communication systems.
Joint modeling method of question intention recognition and slot filling for domain-oriented question answering system
Authors: Wang Huiyong , Yang Ding , Guo Liang , Zhang Xiaoming 
Published: June 2022

Abstract
Question answering systems are developing continuously. To make the machine comprehend the user input discourse better, question processing has become an active research topic of natural language processing. Intention recognition is a semantic classification task and a crucial step in question answering system construction. The effect of intention recognition influences the response of the whole question answering system. Therefore, an efficient intention recognition model plays an important role in the construction of a question answering system. The intention recognition task is correlated with the slot filling task. We propose an improved joint modeling method for intention recognition and slot filling, in which the two tasks are executed simultaneously. The experiment is carried out on two public datasetsATIS and Snips, and the experimental results demonstrate that the proposed model has an optimization effect. Based on the computer literature Knowledge Graph (SCIKG), the domain-specific dataset named CSLQ is constructed. In addition, experiments on the previous joint task model verify the effectiveness of the constructed dataset CSLQ. The experimental results on the three kinds of datasets demonstrate the effectiveness of the proposed model compared with the other methods.
The utilization of health care services by people with type 2 diabetes living in slums in Tabriz, Iran, and sociodemographic factors that influence it: a cross-sectional study
Authors: Ghammari Fawzieh , Jalilian Habib , Khodayari-zarnaq Rahim , Gholizadeh Masumeh 
Published: June 2022

Abstract
Background
As one of the disadvantaged groups, slum-dwellers face health disparities. These disparities can also be attributed to inequalities in health care utilization. Therefore, this study aimed to investigate health care utilization among patients with type 2 diabetes living in Tabriz's slums in 2022.
Methods
A cross-sectional study was conducted. Our study included participants who were over 18 years old, did not suffer from physical and psychological disabilities and had lived in slums for at least 5 years. 13155 patients with type 2 diabetes live in slums in Tabriz, according to the official statistics of the Vice Chancellor for Health at Tabriz University of Medical Sciences. Thus, we selected 400 patients using stratified systematic random sampling. A questionnaire was used to collect data, and SPSS version 22 was used to analyze the results.
Results
Of the 400 patients, 215 were female (53.8%), 323 were illiterate or could read and write (58%) and 303 had low income (75.2%). Only 15% had supplementary health insurance, while 82.3% had basic coverage. Although 49.8% of patients felt they needed outpatient services, only 38.3% were able to receive them. A blood sugar test is the most frequently received service (50%), while psychological counseling is the least frequently received consultation (3.30%). Outpatient services were used more frequently by patients with higher socioeconomic status and those with diabetes complications (P 0.05). The utilization of inpatient services was higher among older and less educated people (P 0.05).
Conclusion
Among slum-dwellers with type 2 diabetes, health care utilization is low. The government and health system should focus on providing adequate education about diabetes and its importance, empowering slum-dwellers to improve self-care and disease management, expanding public insurance coverage, and sufficient coverage of costs by insurance organizations.
Genetic Pleiotropy Underpinning Adiposity and Inflammation in Self-Identified Hispanic/Latino Populations
Authors: Anwar Mohammad Yaser , Baldassari Antoine R. , Polikowsky Hannah G. , Sitlani Colleen M. , Highland Heather M. , Chami Nathalie , Chen Hung-Hsin , Graff Mariaelisa , Howard Annie Green , Jung Su Yon , Petty Lauren E. , Wang Zhe , Zhu Wanying , Buyske Steven , Cheng Iona , Kaplan Robert , Kooperberg Charles , Loos Ruth J.F. , Peters Ulrike , McCormick Joseph B. , Fisher-Hoch Susan P. , Avery Christy L , Taylor Kira C , Below Jennifer E. , North Kari E. 
Published: June 2022

Abstract
Background
Concurrent variation in adiposity and inflammation suggests potential shared functional pathways and pleiotropic disease underpinning. Yet, exploration of pleiotropy in the context of adiposity-inflammation has been scarce, and none has included self-identified Hispanic/Latino populations. Given the high level of ancestral diversity in Hispanic American population, genetic studies may reveal variants that are infrequent/monomorphic in more homogeneous populations.
Methods
Using multi-trait Adaptive Sum of Powered Score (aSPU) method, we examined individual and shared genetic effects underlying inflammatory (CRP) and adiposity-related traits (Body Mass Index [BMI]), and central adiposity (Waist to Hip Ratio [WHR]) in HLA participating in the Population Architecture Using Genomics and Epidemiology (PAGE) cohort (N = 35,871) with replication of effects in the Cameron County Hispanic Cohort (CCHC) which consists of Mexican American individuals.
Results
Of the > 16 million SNPs tested, variants representing 7 independent loci were found to illustrate significant association with multiple traits. Two out of 7 variants were replicated at statistically significant level in multi-trait analyses in CCHC. The lead variant on APOE (rs439401) and rs11208712 were found to harbor multi-trait associations with adiposity and inflammation.
Conclusions
Results from this study demonstrate the importance of considering pleiotropy for improving our understanding of the etiology of the various metabolic pathways that regulate cardiovascular disease development.
Molecular detection and antibiogram profile of Riemerella anatipestifer in duck farming areas of Bangladesh
Authors: Hasan Alamgir , Bose Palash , Aktar Mst Tachlima , Haque Zobayda Farzana , Islam Mohammad Rafiqul , Hossain Muhammad Tofazzal , Siddique Mahbubul Pratik 
Published: June 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
Collisional Dynamics of Dromion Triplet for (2+1) Dimensional Coupled Integrable Maccari’s System
Authors: B Sivatharani , Subramanian K , T Alagesan , S Mani Rajan M 
Published: June 2022

Abstract
Using the Truncated Painlevѐ Approach, this work investigates the (2+1) dimensional coupled integrable Maccari’s system. As a result, the solutions are constructed in terms of arbitrary functions. Utilizing the arbitrary functions present in the solution, a variety of localized solutions such as dromion triplet pairs, dromions and rogue waves are generated. The dromion pairs in the two dimensional plane were constructed and their collisional behaviors were explored by selecting the arbitrary functions with adequate initial parameters. In addition to the dromion triplet pairs, dromions and rogue wave solutions were also generated. It is observed that the dromions and rogue waves are unstable and stationary. Keywords: Dromion triplet pairs, Rogue wave, Truncated Painlevѐ Approach