bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Clinical Study on the Effect of Sarjarasadi Malahara and Vipadikahara Ghrita-Taila in the Management of Vipadika
Authors: Javed Akhtar  , Deepti kaushik  , Sriram Chandra Mishra  
Published: June 2022

Vipadika is one among the several types of skin disorders elaborated by Ayurveda. A randomized open comparative clinical study was done on 30 no of patients diagnosed as Vipadika at V.Y.D.S. Ayurveda Mahavidyalaya, Khurja. They were divided into two groups. In Trial group (TG) 15 cases treated with Sarjarasadi Malahara and in Control group (CG) 15 cases treated with Vipadikahara Ghrita-taila.
The percentage of improvement was 95.13%, 96.79%, 96.15%, 86.68%, 95.13%, 94.57% in Vipadikahara Ghrita-taila and 87.19%, 84.39%, 73.53%, 90.91%, 87.19%, 76.65% in Sarjarasadi Malahara in respect to Panipaada Sphutanam (cracks of hands and feet), Vedana (pain), Kandu (itching), Daha (burning sensation), total number of cracks, total length of cracks. The statistical adjudication with suitable parameters shows that both drugs were extremely/very significant on subjective and objective parameters among both groups. The overall clinical effect of therapy shows that, 73.33% and 33.33% patients get maximum improvement, 26.67% and 53.33% get moderate improvement, 0% and 6.67% get mild improvement with Vipadikahara Ghrita-taila and Sarjarasadi Malahara respectfully.
Defining to the benefits assessed both the drugs were found capable to enforce relief, but based on percentage of improvement and overall result, it can be concluded that Vipadikahara Ghrita-taila was more effective than Sarjarasadi Malahara
Ancient Culinary Science (Soopa Shastra): It’s Usefulness in Today’s Era in Health Point of View
Authors: Khagen Basumatary  , Vinit Kumar Sharma  , Mallika  
Published: June 2022

The role of Ahara is very important in human life. It is called sustenance of life which Acharyas refer as Traya upsthambha that implies support of life. Acharya Charaka has mentioned the three supports of life, as food (Ahara) intake, sleep (Nidra) and observance of celibacy (Brahmacharya). In these three components Ahara is very important because it is Panchabhautika, human body is Panchabhautik and whatever diseases are caused also Panchabhautika and therefore our body would be formed as what we consumed food articles. Gradually human beings started taking cooked food items from raw food materials due to advancement of civilization. Later on because of evolution of food item people used to consume varieties of cooked food items with enhanced nutrition and taste. Therefore Ahara paka process is very important for healthy human life. There are many methods of Ahara paka mentioned in Ayurveda Shastra. After cooking the quality of food item is transformed to a new improved quality from its original quality and this phenomenon is known as Samskara (food processing). That’s why we can say that Ahara cooking (Soopa Shastra) method is an important art which changes quality of our diet accordingly as desired by us in terms of taste, nutrition, health condition and also according to seasonal variations. Therefore Ahara paka plays an important role in keeping people healthy and helps in treatment of ailing conditions and so Ahara paka method is very essential for day to day life. In this research work we have collected the various classical food items along with ingredients, method of preparation, quality and uses in various health conditions described in Brihatrayee, Laghutrayee and different other classics which will be benefited in different context of uses.
Clinical Observations of Folklore Treatment Regimen in the Management of Female Infertility
Authors: Arjun Bhagwan  , Bharathi Kumaramangalam  , Khushboo Jha  
Published: June 2022

Infertility is a global public health issue with an estimated prevalence of infertility ranging from 3.5% to 16.7% in more developed nations and from 6.9% to 9.3% in less developed nations. Female fertility is achieved by coordinated and synchronized functions of Garbha Sambhava Samagri. This synchronization may get disrupted due to various factors or dysfunction of reproductive tract like Artavadushti, Asrugdara, neuroendocrine system like Apanavayu vikruti, and immune system or by any severe systemic disease.
According to Ayurveda, essential factors to achieve fertility are described as Garbha Sambhava samagri, incorporating disease free Kshetra, Rutu, Ambu and Bija and normal psychology (mind) and regulated Vata function at the general as well as specific level are also essential. Many formulations are described in Ayurvedic texts for the management of Infertility. But in the present paper an attempt is being made to present clinical observations of one folklore regimen comprising Jatiphala churna (given three days during Rutukala) and Ashvattha Jata (given during secretary phase). Clinical observations of four infertility cases are presented in the present paper; among the four, three are primary infertility cases and one secondary infertility case. Among the four, two cases got conceived and in two cases regularization of menses, ovulation induction observed. On overall observation, this regimen is giving encouraging results.
Pharmacovigilance for Non-Poisonous Herbal Drugs
Authors: Sunitha M P  , Akshatha M  , Nischal P  
Published: June 2022

Background: An increased importance for the pharmacovigilance of herbal medicines is seen in current times because of the growing demand for the herbal products and herbal medicines globally.
Design: This involves an in-depth study of pharmacovigilance of herbal drugs from the sources such as PubMed, Google Scholar, websites etc. and also classical Ayurvedic Granthas like Charaka Samhita, Sushrutha Samhita, Ashtanga Hridaya and Dravyaguna Vijnana etc
Observations: Knowledge of Aushadha Dravya with respect to its Nama (nomenclature), Rupa (morphology), Guna (qualities of the drug) includes all the factors that prevents adverse drug reactions.
Conclusion: The integration including classical methods of safety assessment tools and modern technology together if adopted, the general notion of public i.e., herbal drugs are safe can be made true. Thus, even a poisonous drug can be used in therapeutics just like ambrosia for a specific diseased condition without any adverse effect as told in Ayurveda
Role of Pradhamana Nasya in Tridoshaja Pratishyaya w.s.r to Chronic Sinusitis
Authors: Chander lata  , Anil Bhardwaj  
Published: June 2022

Sinusitis is considered as one of the most common clinical conditions among chronic diseases. Modification in lifestyle, rise in the cases of antibiotic resistance, deviated nasal septum, nasal polyps, tumors etc. are responsible for increased prevalence of sinusitis. Sinusitis affects 10-30% population whereas Chronic Sinusitis affects approximately 12.5% population each year. Women are more affected in comparison with men. Feature of Sinusitis can be co-related with Tridoshaja Pratishyaya. Acharya Sushruta has mentioned Pratishyaya under 31 Nasagata rogas. In modern science, sinusitis is managed with antibiotics, nasal decongestants sprays, corticosteroids, analgesics etc. Excessive use of decongestant sprays can cause rebound congestion. Person may become resistant to antibiotics. Repeated attacks of sinusitis and fear of surgery may cause depression to the patient. Permanent cure of sinusitis can be achieved through Ayurvedic management. In Brihat Samhita, Nasya has been considered as effective treatment modality for all kinds of Urdhava Jatrugata rogas (diseases of supra clavicular region). Acharya Charaka in Chikitsa Sthana has mentioned Pradhamana Nasya for the management of Kapha Pradhan Pratishyaya. In the present case study, a patient with the symptoms of Kapha Pradhan Tridoshaja Pratishyaya was treated with Manashiladi churna Pradhamana Nasya. Patient got complete relief in sign and symptoms.
THE USE OF A CELL-FREE PROTEIN SYNTHESIS FOR OBTAINING BACTERIAL DIGUANYLATCYCLASE AND TWO CHIMERIC PROTEINS
Authors: Kazlouski I. S. , Belskaya I. V. , Bulatovskiy A. B. , Zinchenko A. I. 
Published: June 2022

The novel promising trend of biotechnology is cell-free synthesis of proteins. Possibility of producing two chimeric proteins: adenosine deaminase of Escherichia coli fused with human annexin-A5, DNA-affine domain of bacteria Sulfolobus solfataricus fused with modified Taq-DNA-polymerase and bacterial enzyme diguanylatecyclase of Thermotoga maritima, by cell-free synthesis procedure as an alternative to conventional cultivation of microbial strains-producers in a bioreactor was studied in this research. Chimeric RNA polymerase of T7 bacteriophage, S30-cell extract of E. coli and multicopy plasmid pET42mut were engaged for protein synthesis by cell-free protein synthesis system. The first successful production of these proteins was demonstrated
in CFPS system.
ROLE OF IRF5 GENE POLYMORPHISM IN PREDISPOSITION TO JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS IN THE BELARUSIAN POPULATION
Authors: Bakutenko I. Y. , Haurylchyk I. D. , Sechko E. V. , Tchitchko А. М. , Sukalo А. V. , Ryabokon N. I. 
Published: June 2022

The IRF5 (interferon regulatory factor 5) gene encoding a transcription factor is involved in the regulation of interferon synthesis and other proinflammatory cytokines. It is assumed that the IRF5 gene is associated with juvenileonset systemic lupus erythematosus (jSLE), a chronic autoimmune disease that develops in childhood and differs from the adult subtype of SLE in a number of its manifestations. The aim of the presented work was to conduct a pilot study of IRF5 rs2004640 polymorphism in the population of children in Belarus and its association with the development of jSLE. Genotyping of DNA samples was performed using real-time PCR in a group of patients diagnosed with
jSLE (38 people) and in the clinical control group without autoimmune and inflammatory diseases (378 people). The frequency of the IRF5 rs2004640 minor T allele was determined in the Belarusian population of children (under the age of 17). It was found that the rs2004640 TT genotype is associated with the risk of the jSLE development (OR = 2.27; 95% CI 1.08–4.76; p = 0.035) that after further investigations may improve an early diagnosis of jSLE.
DETERMINATION OF MINIMUM SAMPLE SIZE FOR THE PREDICTION OF HUMAN CHRONOLOGICAL AGE
Authors: Kipen V. N. , Bahdanava M. V. , Burakova A. A. , Dobysh O. I. , Zotova O. V. , Koroleva T. S. , Bulgak A. G. , Baida A. V. , Bruskin S. A. , Lemesh V. A. 
Published: June 2022

Based on the data presented in the public domain on the GEO-NCBI Platform for 21 projects to determine the genomewide
DNA methylation profile using the Infinium Human Methylation 450K BeadChip (Illumina©), we calculated the prediction error for chronological age values in percentage terms and MAD using three different algorithms: linear regression, generalized regression neural networks and multilayer feedforward neural networks. For each algorithm, we have provided guidelines to select the samples for the study. We have also proved that the minimum and sufficient sample size, an increase in which does not lead to a significant decrease in the MAD value, is at least 200 people.
Association of Chronic Hepatitis C in Type 2 Diabetes Mellitus Patients in HMC Hospital Peshawar
Authors: Afridi Muhammad Hussain , Khan Muhamamd Naeem , Khan Atta Muhammad , Abbass Muhammad , Khan Muhammad Khalid , Gul Wali , Zaib Shah 
Published: June 2022

Background: Hepatitis C virus is a blood-borne virus, and the vast majority of infections are the result of blood exposure from unsafe injection practices, poor health care, unscreened blood transfusions, injection drug use, and sexual practices that result in blood exposure. Chronic (CHC) infection is caused by the hepatitis C virus, and affected nearly 198 million people worldwide.
Objective: To determine whether there was a link between hepatitis C virus infection and Diabetes Mellitus.
Methodology: After receiving approval from the Hospital's Ethical Committee, this study was conducted over a one-year period (15-01-2018 to 16-01-2019) to investigate the relationship between HCV infection and D.M patient reports at the Diabetic Department of Diabetes and Endocrinology HMC Hospital in Peshawar. An enzyme-linked immunosorbent assay (ELISA) was used to measure anti-HCV antibody, as well as glycosylated hemoglobin (HbA1c) and fasting and random blood sugar levels. SPSS version 2.1 was used to analyses the data.
Results: average of all patients ages (n=238) was 51.3811.35 years. Patients were split evenly between males and females, with 128 (52%) males and 110 (48%) females. In the group of type 2 D.M patients who tested positive for hepatitis C by ELISA, 44 (18.8%) had diabetes and 194 (82.2%) did not.
Conclusion: Type 2 diabetes mellitus is more common Chronic Hepatitis C infection, increasing age, and a positive family history of Diabetes Mellitus according to the findings.
Placental weight Birth weight Ratio, in patients with Placenta Previa: A 2 year study in MTI Lady Reading Hospital Peshawar
Authors: Bawar Shandana , Shafqat Tanveer , Hussain S Saima , Qazi Qudsia , Rahim Rehana 
Published: June 2022

Purpose: To review the placenta weight birth weight ratio (PWBW ratio) and determine an association between PWBW ratio and gestational age in patients with placenta previa.
Methodology: This descriptive cross sectional study took place in Gynae A unit, Medical Teaching Institute, Lady Reading Hospital, Peshawar, Pakistan, from March 2018 to February 2020.Ethical approval from IRB (institutional review board) was taken before start of study. Patients with genital tract bleeding were admitted throughout patient department and Emergency with 28 weeks gestation and onwards. Diagnosis of placenta previa was confirmed and were included in study after taking consent.
Results: Total of 173 patients with placenta previa were admitted in gynae A. Patients with major placenta previa were 151 (87.2%) while 22 (12.7%) patients had minor placenta previa. Birth weight placental weight ratio was calculated by measuring weight of placenta and baby after the delivery. Most of the patients, 92 (53.2%) had PWBW ratio less than 1:6 (relatively large placenta), patients with BWPW ratio of 1:6 (normal ratio) were 14 (8.1%) and 67 (38.7%) patients had PWBW ratio of 1:6 (relatively smaller placenta). Patients with placenta previa have relatively larger placenta (PWBW ratio less than 1:6) to compensate for lesser vasculature of lower uterine segment. Patients with larger placenta are prone to necrosis and abruption.
Recommendation: igilant antenatal care and surveillance in these patients due to higher incidence of antepartum and postpartum hemorrhage, as well as invasive propensity of lager placenta.
Impact of CT Enhanced Syntax Score (Ctesx) on Grading Complexity of Coronary Artery Disease
Authors: Zarif Bassem , Cherif Ehab , Shafiq Mohammad , Hanafy Marwa Ahmed , Mahmoud Hesham B 
Published: June 2022

Purpose: The SYNTAX Score is a crucial tool to grade angiographic complexity and risk stratification of patients for revascularization. Excessive coronary calcification can lead to adverse outcomes after percutaneous coronary intervention (PCI), and it represents an essential part of SYNTAX score calculation. The sensitivity in detecting any CAC by CT is much higher than in ICA. Our purpose is to evaluate the impact of CT-enhanced calcium detection on SYNTAX score in the evaluation of complex coronary anatomy.
Methodology: This study was conducted at Beni-suef University Hospital and National Heart Institute from December 2019 to January 2021. Fifty consecutive male patients were enrolled, Their Coronary CT Angiography showed significant MVD; then, conventional coronary angiography was done. The additive value, rather than the comparative value, of adding Calcification from CT to CA syntax score (CT enhanced SYNTAX (CTeSx)), was assessed regarding its impact on the classification of complexity.
Findings: Using a CTeSX Vs CA Sx results in Lower Possibilities of Low Syntax group (39% vs 24%) (P-value <0.001) and a higher Possibilities of High Syntax score (23% vs 52% P-value 0.004
Recommendation: CTeSX results in a significant change in the percentage of all complexity categories with a higher possibility to categorize complex anatomy.
Surgical Management of Glioblastoma Multiforme
Authors: Ul Haq Ul Haq , Khan Muhammad Idris , Jalal Abdul , Shah Inyat , Khan Musawer 
Published: June 2022

Background: Although glioblastoma (GB) is kept up to date, rate of progress is nearly unavoidable. Earlier researches put forward the endurance advantages with removal of GB; but comparatively a small number of literatures have assessed the role of operative intervention in glioblastoma management.
Objective: The aim of this research is to assess the results of surgical resections in patients with glioblastoma.
Methods: Study conducted in Bacha Khan Medical College, Mardan Medical Complex Records were retrospectively identified and reviewed for all individuals that went through gliolastoma biopsy or its removal between Oct 2017 and Dec 2020 to identify 50 progressive GB patients. The Kaplan-Meier method produced median survival and 95 percent CI. The Cox Proportional Risks model was used for the multivarian analysis, which conducted for age, Karnofsky score, extent of resection, and tumor site and tumor multifocality of survival after the advancement of disease.
Results: Patients with progressing illness received first recorded resection. The median survival after progression was 12.8 and 7.0 months for patients who had not received resections at this time. In multivariable analyses, KPS 0.70 (HR 0.438), and surgical intervention were linked with better survival after advancement of glioblastoma.
Recommendations: In the circumstance of present maximum non-operative treatment, operative intervention for advancing glioblastoma is effective in controlling the symptoms but however, the survival of the patients is limited. Further research is required to determine if any, the role of surgical intervention may prolong post-progressive endurance in progressive GB individuals.
ATIVIDADES DOMICILIARES DIRECIONADAS EM TEMPO DE PANDEMIA: ESTUDO DE CASO EM UM MUNICÍPIO DE RORAIMA
Authors: Silva Monaliza Nayara Ribeiro , Silva Rocha Soares Livia Késsia da 
Published: June 2022

Este estudo tem como objetivo compreender as dificuldades que os professores apresentam na elaboração das atividades domiciliares direcionadas, em integrar as diferenças que permeiam o ambiente escolar, acerca de documentos como a Base Nacional Comum Curricular- BNCC e o Documento Curricular de Roraima- DCR/RR? Deste modo, o método adotado nesta investigação é o estudo de caso, operacionalizado pela entrevista estruturada. Os sujeitos da pesquisa são quatro professores de diferentes etapas de ensino da rede municipal. Um dos desafios é mediar a integração intercultural das aulas e atividades desenvolvidas. O município de Pacaraima/Roraima está localizado na fronteira Brasil/Venezuela e apresenta grande diversidade cultural. Com isso, um plano de trabalho emergencial foi elaborado por gestores, coordenadores e professores resultando na entrega de apostilas sistematizadas e unificadas aos alunos da rede municipal de ensino, ficando evidente que os professores tentam de uma forma ou de outra fazer essa integração intercultural na sua sala de aula.
The Optimal Integration of Multiple DGs under Different Load Models using Artificial Bee Colony-Hill Climbing Algorithm
Authors: Mallaiah Lokesh , Kulkarni Ananth D. , Prasad Babu Rajendra , Tammaiah Ananthapadmanabha 
Published: June 2022

With the continual advances in technologies, there is a significantly increased demand for electricity leads to a drastic increase in usage and penetration of DGs into the distribution network. The incorrect addition of DGs into the distribution system resulting in declining stability, power losses, voltage profile, reliability, and power quality of the system. Therefore, the optimal planning of DGs (OPDG) has always been under constant investigation and development for the maximum beneficiary. The proposed framework presents a novel meta-heuristic hybrid optimization technique called Artificial Bee Colony-Hill Climbing (ABC-HC) to find the best siting and sizing of multiple DGs using a weighted multi-objective function which includes real and reactive power loss index and voltage deviation index. The results clearly indicate the significant reduction in losses and voltage deviation achieved by integration of single and multiple DGs. The research work is also extended to assess the voltage harmonics of the system before and after the placement of DGs. The effectiveness of the proposed ABC-HC algorithm has been demonstrated on the standard IEEE-33 bus RDS under different voltage dependent load models using MATLAB 2017a.
HIGHLIGHTS

As demand grows, technologies advance, and power system infrastructure changes, there are more opportunities to integrate distributed generators into the distribution system
The maximum benefit from the DG integration is achieved by selecting the optimal size and optimal site in the distribution system
A new hybrid optimization technique has been developed for optimal planning of DGs under different voltage dependent loads. The work was also extended to carry out harmonic analysis

GRAPHICAL ABSTRACT
Corrosion Behavior of AISI 316L Stainless Steel in a Highly Sour Environment
Authors: Shah Mazlan , Yaakob Najmiddin , Ayob Muhammad Taqiyuddin Mawardi , Othman Norinsan Kamil 
Published: June 2022

Sour corrosion in the presence of H2S gases can significantly affect the passive films deterioration of the 316L steel. 0 and 3 bar of H2S gases were chosen to identify how H2S gases could affect the corrosion rate on steels surface at normal and extremely sour conditions. Experiment was operated in an 7L autoclave for 7 days and was kept at 60 °C throughout the testing. The uniform corrosion rates were measured by weight loss while the pitting corrosion rates were determined by using a profilometer, respectively. The oxide layers formed under these conditions were determined by XPS. The results found that at 3 bar of H2S gas condition shows the formation of multi-layers consist of Fe3O4, (NiOH)2, NiO, MoO3, FeS, and NiS. Finally, corrosion products formation on 316L steels surface was then discussed.
HIGHLIGHTS

The corrosion-resistant alloy (CRA) has been introduced to the pipeline industry due to its excellent properties of corrosion resistance but still remains unclear in a highly sour environment and needs to be further investigated
316L steel was selected because it is one of the austenitic alloys containing chromium, nickel and molybdenum, making it more corrosion resistant
The effects of H2S gas pressure on the AISI 316L stainless-steel, with the emphasis on the formation and deterioration of passive films have been discussed

GRAPHICAL ABSTRACT