bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of irrigation and fertilisation on the biologically active components of tomato
Authors: Schmidt-Szantner B. , Gasztonyi M. , Milotay P. , Tömösközi-Farkas R. 
Published: June 2022

Abstract
A three-year (2016–2018) open field experiment was conducted to study the effect of irrigation, fertilisation, and seasonal variation on the main bioactive components, such as carotenoids (lycopene and β-carotene), total polyphenols, antioxidant capacity, and tocopherols of processed Uno Rosso F1 tomato. The statistical evaluation of measurements proved that the multi-year data set cannot be evaluated as combined data set; the values obtained in different years must be evaluated separately. The impact of irrigation on the content of bioactive components varied from year to year. The correlation was negative between irrigation and α-tocopherol content in 2016 and 2018 (r = –0.567 and –0.605, respectively), polyphenol content in 2016 (r = –0.668), γ-tocopherol content in 2017 (r = –0.662), while positive correlation was observed between concentration of vitamin C (r = 0.533) in 2017, lycopene content (r = 0.473) in 2018 and irrigation intensity. A weak correlation was proved between K levels and concentrations of lycopene and polyphenols in 2016 (r = 0.301 and r = 0.392, respectively).
Some pharmacological propertyes of Chamerion angustifolium infusions
Authors: Barnaulov Oleg D. 
Published: June 2022

BACKGROUND: Chamerion angustifolium has been popular among the people for many centuries as a substitute for tea and a mild sedative. Leaf infusions are used for neurosis, cephalgia, epilepsy and other neurological diseases.
AIM: Was to experimentally confirm the cerebroprotective properties of Chamerion leaf infusions.
METHODS: We used the methods of maximum electric shock, conditioned passive avoidance, and immobilization stress in rats and mice.
RESULTS: Infusions of leaves experimentally revealed no anticonvulsant properties. Cerebroprotective properties were manifested in the preservation of the passive avoidance conditioned reflex after maximum shock and faster recovery of exploratory behavior. Distinct stress-limiting properties were revealed during immobilization stress in mice. Fermented leaves have been shown to be less effective than non-fermented ones.
CONCLUSION: The data obtained confirm the presence of cerebroprotective properties of the infusion of Chamerion angustifolium.
Does succinate as a structural component of a drug enhance efficacy of treatment of asthenic disorders in patients with somatic injuries?
Authors: Buznik Galina V. 
Published: June 2022

AIM: The aim was to assess the efficacy of treatment of asthenic syndrome in patients with combined injuries by means of succinate containing metabolic drugs (Mexidol, Cytoflavine, Metaprot plus) in comparison with non-succinate containing drugs of analogic structure or composition (Emoxipine, Riboxine, Metaprot) to clear up the significance of succinate as a functional structural element of the molecule.
MATERIALS AND METHODS: In 134 surgical patients and sufferers with combined injuries, an asthenic syndrome (high anxiety, depression, high psychic and physical tiredness, weakness, absent-mindedness, attention disorders, reduced physical and psychical ability, need in durative rest, high psychic exhaustion, social disadaptation) was revealed by clinical, psychological and instrumental methods.
RESULTS: Metabolic drugs containing succinate (Mexidol, Cytoflavine, Metaprot plus) in more degree than non-containing succinate in their structure (Emoxipine, Riboxine, Metaprot) were clinically effective in abolition or reduction of the asthenic syndrome in such patients. Antiasthenic action was represented by proper antiasthenic, antidepressant, anxiolytic, nootropic (cognitive) and positive general somatic effects of the drugs.
CONCLUSION: The data confirm that succinate in the structure (composition) of the metabolic drugs significantly enhances protective action against asthenic syndrome in surgical patients with combined injuries.
Evaluation of the Event Detection Level of the Cuban Seismic Network
Authors: Diez Zaldivar Eduardo R. , Priolo Enrico , Sandron Denis , Poveda Brossard Viana , Cattaneo Marco , Marzorati Simone , Palau Clares Raúl 
Published: June 2022

Abstract
The detection level of a seismic network is a measure of its effective ability to record small earthquakes in a given area. It can vary in both space and time and depends on several factors such as meteorological conditions, anthropic noise, local soil conditions—all factors that affect the seismic noise level—as well as the quality and operating condition of the instruments. The ability to estimate the level of detection is of tremendous importance both in the design of a new network and in determining whether a given network can recognize seismicity consistently or needs to be improved in some of its parts. In this article, we determine the detection level of the Cuban seismic network using the empirically estimated seismic noise spectral level at each station site and some theoretical relationships to predict the signal amplitude of a seismic event at individual stations. The minimum local detectable magnitude thus depends on some network parameters such as the signal-to-noise ratio and the number of stations used in the calculation. We also demonstrate the effectiveness of our predictions by comparing the estimated detection level with those empirically determined from one year of data (i.e., the year 2020) of the Cuban seismic catalog. Our analysis shows, on the one hand, in which areas the current Cuban network should be improved, also depending on the regional pattern of faults, and, on the other hand, indicates the magnitude threshold that can be assumed homogeneously for the catalog of Cuban earthquakes in 2020. Because the adopted method can use current measurements of the seismic noise level (e.g., daily), the proposed analysis can also be configured for continuous monitoring of network state quality.
Seismogenic Structure of the 2017 Ms 6.6 Jinghe, China, Earthquake Inferred from Seismic Detection and Relocation
Authors: Qiu Yongkang , Xu Caijun , Xiao Zhuohui , Wang Jianjun 
Published: June 2022

Abstract
On 8 August 2017, an Ms 6.6 earthquake occurred in Xinjiang province, Northwest China. As no visible surface ruptures, coupled with the complex regional fault systems, the seismogenic structure of the earthquake is still unclear. Rich aftershock data can constrain the fault structure to some extent, but only a handful of aftershocks were recorded by the China Earthquake Networks Center (CENC) in this case. To augment the CENC catalog, we first relocated aftershocks and then adopted them as templates to scan the continuous waveforms five days before and five days after the mainshock using the Match and Locate method. We successfully detected 3.5 times more events than the CENC catalog, and the detected events discernibly feature a south-dipping plane. Amalgamating the focal mechanism of the mainshock and available geological information, the south-dipping thrust Jinghenan fault is inferred to be the rupture fault of the Jinghe earthquake. In addition, we find that the detected foreshocks are mainly distributed on the northwest edge of asperity where the mainshock may have nucleated. In addition, based on the cluster analysis and spatial–temporal evolutions of detected events, we speculate that a backthrust branch related to the seismogenic fault was activated during the aftershocks moving significantly westward in the first 30 min after the mainshock occurrence.
Identification of active compounds in red onion (Allium ascalonicum) peel extract by LC-ESI-QTOF-MS/MS and determination of its antioxidant activity
Authors: Maryuni Dela Retno , Prameswari Destia Ayu , Astari Saffarina Dini , Sari Salsabila Permata , Putri Desiana Nuriza 
Published: June 2022

<p>Red onion is one of the foodstuffs that people in everyday life widely use, but 10% of red onion cannot be consumed and only becomes waste, namely the peel of the onion. Although the peel of the onion is a waste, the peel of the onion contains flavonol compounds from the flavonoid group that has the potential as antioxidants. So this study was conducted to determine the compounds in the red onion peel that acts as antioxidants. The extraction method used in this research is the maceration method with 80% ethanol solvent. The compound content test was carried out by testing phytochemical compounds by identifying flavonoid compounds, polyphenols, steroids and terpenoids, saponins, alkaloids, anthocyanins, antioxidant activity, and identification of compounds using LC-MS. The study results on qualitative testing of phytochemical compounds showed that the onion peel extract contained positive flavonoids, polyphenols, and saponins. Meanwhile, the identification of compound content of onion peel extract using LC-MS detected flavonoids (14 compounds), polyphenols (1 compound), saponins (2 compounds), and alkaloids (1 compound). The antioxidant activity of the ethanolic extract of the onion peel has obtained an average of 77%, and the total anthocyanin content was an average of 17.87 mg/L. It was found that the natural antioxidant of onion peel extract showed good primary oxidation inhibition ability. So it can be concluded that onion peel extract is effectively used as a natural antioxidant.</p>
Reference intervals for metabolic profile of adult sheep in the tropics: over 12 months
Authors: Schultz Erica Beatriz , Conceição Aline Rabello , Siqueira Marco Tulio Santos , Oliveira Karla Alves , Sousa Luciano Fernandes , Junior Gilberto de Lima Macedo 
Published: June 2022

Abstract
Metabolite levels can vary according to the farming region, age, physiological state and feeding of the animal, therefore, the objective was to estimate reference values for the energy, hepatic and mineral profiles of sheep (above 12 months) in the tropics. For this, data from healthy adult sheep, raised in different management systems in Brazilian institutions from 2006 to 2017 were used. To determine the energy profile, data were obtained for glucose, cholesterol, triglycerides, fructosamine, HDL (high density lipoprotein), LDL (low density lipoprotein) and VLDL (very low density lipoprotein); for the protein profile, total protein, uric acid, urea, albumin and creatinine data; for the mineral profile, values of calcium, phosphorus and magnesium; and for the enzymatic profile, data on AST (aspartate aminotransferase), GGT (gamma glutamyl transferase), alkaline phosphatase. The estimation and determination of reference values was performed in the RefVal 4.11 software, where outliers were removed, using the Dixon test, and the percentiles, as well as their confidence intervals, estimated by the non-parametric bootstrap method, when data did not show normal distribution. The defined confidence interval was 95%. Most metabolites presented intervals extrapolating both the lower and upper limits recommended in the international literature, especially cholesterol, fructosamine, urea and phosphorus. As for the enzymatic profile, the AST and alkaline phosphatase intervals assumed, as an upper limit, values below those recommended by the international literature. In conclusion, the intervals defined from the national data present differences in relation to the international ones, since only adult animals were considered, while those from international data do not make a distinction regarding the animal category.
Making the case for parks: Construction of an ecological network of urban parks based on birds
Authors: Yang Yang , Zhou Yanru , Feng Zhe , Wu Kening 
Published: June 2022

Abstract
Urban expansion occurs in horizontal and vertical directions, but the traditional planar ecological network (EN)’s construction process ignores the vertical space’s ecological protection. Birds, as representative species in urbanized areas, are important for expanding the vertical analysis dimension of ENs. In this study, urban parks with good habitat quality are extracted as ecological sources from the perspective of birds. Then, 2D and 3D ecological resistance surfaces are constructed on the basis of the perspective of influencing bird migration, and planar and 3D ecological corridors are extracted and compared for analysis. Lastly, accessibility analysis is performed to identify the parks in the study area that need priority protection. Results show that building height is an important factor affecting bird migration, and the introduction of 3D resistance surfaces into EN construction is important for adapting to the trend of vertical urban expansion. The combination of accessibility and EN analyses can help identify ecological spaces with the dual role of “species conservation” and “human well-being enhancement.” This study can provide a reference for refining the service species of ENs, exploring the vertical dimension of ENs, and improving the health of urban ecosystems and the rationality of urban planning.
Knockdown of long noncoding RNA 01124 inhibits the malignant behaviors of colon cancer cells by regulating miR-654-5p/HAX-1
Authors: Wu Yujin , He Runming , Cai Zhiquan , Wang Xuechuan , Cong Longling , Qiu Fanghua 
Published: June 2022

Abstract
Background
Previous studies have shown that long noncoding RNAs (lncRNAs) play a key role in cancer, including colon cancer (CC). However, the exact role of long noncoding RNA 01124 (LINC01124) in CC and its mechanisms of action remain unknown. In the present study, we aimed to investigate the functional effects and the possible mechanism of LINC01124 in CC.
Results
we demonstrated that LINC01124 was upregulated in colon cancer tissues and cell lines. Further functional studies showed that knockdown of LINC01124 significantly suppressed the proliferation, migration and invasion of colon cancer cells in vitro and in vivo. Moreover, in subsequent mechanistic experiments, LINC01124 was found to act as a sponge to suppress microRNA 654-5p, which targeted HAX-1. Downregulation of LINC01124 decreased the expression of HAX-1, and overexpression of a miR-654-5p inhibitor attenuated the sh-LINC01124-induced inhibition of CC cell proliferation, migration and invasion.
Conclusion
Collectively, all the results revealed a role for the LINC01124/miR-654-5p/HAX-1 axis in the tumorigenesis and progression of CC, suggesting that LINC01124 may be a therapeutic target for colon cancer treatment.
Surgical administration of indocyanine green in hepatectomy for improved bile leakage detection
Authors: Hanaki Takehiko , Goto Keisuke , Morimoto Masaki , Murakami Yuki , Matsunaga Tomoyuki , Yamamoto Manabu , Tokuyasu Naruo , Sakamoto Teruhisa , Hasegawa Toshimichi , Fujiwara Yoshiyuki 
Published: June 2022

Abstract
To study the effect of fluorescence imaging via systemically administrated indocyanine green (ICG) for preventing bile leakage (BL) from the resected liver surface. ICG leakage from the resected liver surface was used to identify BL. Bilirubin levels in patients’ drainage effluent whose BL from the resected liver was observed the naked eye and those whose ICG leakage was used as a BL indicator were compared. Twenty-six patients who underwent hepatectomy without ICG (conventional observation group, CO-G) and 23 hepatectomy patients who underwent intraoperative BL detection using ICG (ICG observation group, IO-G) were enrolled. In the IO-G, the number of BL spots on the resected plane visible to the naked eye was compared with the number of visible spots on an ICG camera. Three days post-surgery, the drainage fluid’s bilirubin levels of the IO-G were significantly lower than those of the CO-G (1.3 vs. 1.9 mg/dL, p = 0.019). Two ISGLS grade B biliary fistula cases (7.7%) occurred in the CO-G, but none in the IO-G. In the IO-G, the number of BL spots detected just after hepatectomy was significantly higher using ICG camera than the naked eye (0.22 vs. 0.91 spots, p < 0.001). These findings suggest that observation with systemically administrated ICG can detect BLs more sensitively than conventional naked eye observation, enabling rapid repair and potentially preventing biliary fistula.
Embryotoxicity and teratogenesis of orthodontic acrylic resin in zebrafish
Authors: Ohashi Amanda Sayuri Cardoso , Pizzato Christiane Staub , Schacher Helena Reis de Souza , Vianna Monica Ryff Moreira Roca , de Menezes Luciane Macedo 
Published: June 2022

Abstract
Objectives: To verify in vivo the embryotoxicity, teratogenic power and other possible effects of the orthodontic acrylic resin and its components separately using Zebrafish as a model organism. Materials and Methods: Embryo and larval stage animals were divided into 5 experimental groups. These were divided into 5 subgroups: three specific doses of each substance tested, one control with the vehicle (0,1% DMSO in water) and one absolute control (water). In the 5o day post fertilization, the animals were submitted to morphological, cardiac, behavioral, and cognitive evaluations. Ten animals were used in triplicate for all experiments. Survival and hatching were analyzed by the Kaplan Meier test and the other measurements were analyzed by one way ANOVA and Tukey post hoc test. Results: For all tested substances, statistically significant differences were found between the control and treated groups for heart rate, cognitive responsiveness, and cellular apoptosis, whereas survival, hatching rate and other parameters did not show significant differences. Only the highest dose of the dibutyl phthalate group showed significant difference in survival. Conclusions: Chronic exposure to acrylic resin and its components may be associated with decreased cognitive ability and cardiac rhythm and an increase in the level of cellular apoptosis in zebrafish. Clinical Relevance: Acrylic resin widely used in dentistry, where not only the patient stays in contact with it for a long period of time, but the dental and laboratory staff also often for a lifetime. Considering this, we emphasize the importance of further investigating the long-term effects of acrylic resin.
Synthesis of Vapochromic Dyes with Highly Aggregative Characteristics and Their Application to Cotton-based VOC Sensors
Authors: Lee Junheon , Park Namju , Kim Taekyeong 
Published: June 2022

Abstract
The objective of this study was to fabricate cotton-based sensors exhibiting recognizable color change on exposure to vapor phase of volatile organic compounds (VOCs) at room temperature. Three vapochromic dyes (DiMo, MoMe, DiMe) with different substituents were synthesized and investigated on their color change properties after exposure to 32 organic solvents after dyeing on cotton fabrics. The cotton-based sensor exhibited strong sensing properties to polar solvents rather than non-polar solvents. Especially, N,N-dimethylformamide (DMF) detection was the best showing a color difference of 12.8 for DiMo, 21.4 for MoMe, and 25.8 for DiMe under 300ppm exposure. Even at as low concentration as 10ppm of DMF, the color change values were reached 7.3, 10.6, and 13.6 within an hour. The maximum absorption wavelength of the cotton-based sensor was shifted from 580nm to 560nm, 570nm to 560nm, and 560nm to 540nm, respectively, by the DMF exposure. The sensing mechanism was considered to depend on solvatochromism, aggregational properties of the dyes and adsorption amount of VOCs on textile substrates on which the dyes were applied. Finally, the reusability of the cotton-based sensor was tested for 10 cycles.
Various sedimentary facies of tsunami deposits in the lowlands along the eastern margin of the Japan Sea, northern Hiyama District, Hokkaido, Japan
Authors: Kase Yoshihiro , Kawakami Gentaro , Nishina Kenji , Urabe Atsushi , Koyasu Hiromichi , Takashimizu Yasuhiro 
Published: June 2022

Abstract
A tsunami deposit investigation was conducted to verify the presence and source of tsunami deposits in northern Hiyama district, southwest Hokkaido, Japan. Three (Th-2–Th-4) and one (Ku-2) possible tsunami deposits were identified in the Hirahama and Kumaishi-Ayukawa lowlands, respectively. Th-2–Th-4 were divided into sands (Th-2) and gravels (Th-3–Th-4), although they were found in almost the same sites. These differences might have been in harmony with beach clastics as their sources during the Th-2 and Th-3–Th-4 events. It was possible that strong tsunami return flow eroded and transported sands seaward, leaving only gravels behind. Ku-2 consisted of volcanic-ash sands with the overlying silts and showed three fining-upward sequences (Units A–C). The modal compositions of Units B–C were distinct from beach and river sands, although that of Unit A was similar with beach and river sands. The chemical composition of volcanic glasses of Ku-2 indicate that volcanic-ash sands originated from reworked tephra. Considering the rounded clastics, landward paleocurrent, and high proportion of marine–brackish diatoms in Unit B, volcanic-ash sands might have been widespread in the seafloor as a provenance beyond the foreshore and were transported by tsunami run-up flow. Seaward paleocurrent of Unit C was interpreted as return flow. The sedimentary process of Unit A remains unclear because of lack of sedimentary structures and diatoms. Unit A might have been formed by a series of tsunami or lahar. Based on radiocarbon dating, tephrochronology, historical records, and known paleotsunamis in the adjacent area, Th-2 and at least Units B–C, Th-3, and Th-4 could be correlated with AD1741, 12th century, and 2.4–2.6 ka tsunamis, respectively. Considering turbidites in the Shiribeshi Trough, it is reasonable that ca 2–2.6 ka event deposits were formed by the same earthquake with accompanying tsunami. Further studies are needed on whether tsunami deposits—correlated with abovementioned tsunami event—existed in central Hokkaido or southern Hiyama District, where effects of tsunamis triggered by the active faults of F14/F15 and F17/F18 were much stronger, respectively. Confirmation of existence is expected to help clarify the activity record of tsunami sources in southwest Hokkaido.
D-dimer/albumin ratio is a prognostic marker for patients with aneurysmal subarachnoid hemorrhage-retrospective research
Authors: Wu Wei , Liu Xun-Zhi , Chen Xiang-Xin , Sheng Bin , Zhang Jia-Tong , Li Wei , Zhang# Ding-Ding , Hang# Chun-Hua 
Published: June 2022

Abstract
Background
Aneurysmal subarachnoid hemorrhage (aSAH) is a serious neurological disorder with limited treatment options and very little is known about its pathophysiology. And there are few available objective tools for predicting the clinical prognosis of aSAH patients and further aiding in directing clinical therapeutic programs. This study aimed to evaluate whether the raised serum D-dimer/albumin ratio (DAR) could reflect disease severity and predict clinical outcomes after aSAH.
Methods
A total of 178 patients with aSAH were included in this retrospective study. Collected data included demographics; clinical severity of aSAH (WFNS scale and Hunt-Hess scale), levels of D-dimer, albumin, c-reactive protein (CRP), leukocyte counts, mRS on admission; and three-month prognosis. Clinical prognosis was dichotomized into favorable outcome (mRS ≤ 2) and unfavorable outcome (mRS ≥ 3). And the predictive ability of DAR for aSAH prognosis was determined by Receiver Operating Characteristic (ROC) Curve analysis.
Results
The serum DAR showed a strong positive correlation with disease severity. Univariate analysis revealed that DAR, WFNS grade, Hunt-Hess grade, delayed cerebral infarction (DCI), age, neutrophil-to-lymphocyte ratio (NLR), and c-reactive protein/albumin ratio (CAR) were associated with unfavorable clinical outcome. Multivariate regression analysis further revealed that elevated DAR could predict poor prognosis after correcting for WFNS grade, Hunt-Hess grade, DCI, age, NLR, and CRP/albumin ratio. The receiver operating characteristic curve result demonstrated that DAR was a comparable predictor for clinical outcome of aSAH in comparison with NLR and CAR.
Conclusion
DAR was d promising objective tool for aSAH patients. Hight content DAR was associate with disease severity and unfavorable short-term prognosis.