bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergy of stochastics and inelasticity at multiple scales: novel Bayesian applications in stochastic upscaling and fracture size and scale effects
Authors: Ibrahimbegovic Adnan , Matthies Hermann G. , Dobrilla Simona , Karavelić Emir , Nava Rosa Adela Mejia , Nguyen Cong Uy , Sarfaraz M. Sadiq , Stanić Andjelka , Vondřejc Jaroslav 
Published: June 2022

AbstractThe main goal of this review is to provide a thorough scientific understanding of the interplay between stochastics and mechanics, by classifying what can be achieved by representing mechanical system parameters in terms of deterministic values (homogenization) versus random variables or random fields (stochastic upscaling). The latter is of special interest for novel Bayesian applications capable of successfully handling the phenomena of fracture in both the quasi-static and the dynamic evolution of heterogeneous solids where no scale separation is present, which we refer to as stochastic upscaling. We seek to quantify the sensitivity of these phenomena with respect to the size-effect (changes in characteristic system dimension) and to the scale-effect (changes in characteristic time evolution). The challenge is to provide an answer as to why a system that is big does not break under quasi-static loads in the same way as a small system, even when both are built of the same material, and further extend this to inelasticity and fracture under dynamic loads. We plan to illustrate the crucial role of fine-scale heterogeneities and to develop the ground-breaking concept of stochastic upscaling that can capture their influence on instability and dynamic fracture at the system macro-scale. The stochastic upscaling is the key to size and scale laws in the proposed multi-scale approach, which can reach beyond homogenization to properly account for epistemic uncertainties of system parameters and the stochastic nature of dynamical fracture.
Revisiting the antidepressant-like effects of desipramine in male and female adult rats: sex disparities in neurochemical correlates
Authors: Ledesma-Corvi Sandra , García-Fuster M. Julia 
Published: June 2022

Abstract
Background
The preclinical antidepressant-like characterization of desipramine relied almost exclusively in male rodents, with only a few contradictory reports done in females. Given that most experiments assessed a single dose and/or timepoint of analysis after-treatment, this study evaluated potential sex-differences in the length of the antidepressant-like response induced by different doses of desipramine as well as the molecular underpinnings driving the different responses by sex.

Methods
Male and female Sprague–Dawley rats were treated (i.p.) with 3 pulses of desipramine (5, 10 or 20 mg/kg) or vehicle (0.9% NaCl) within 24 h. The antidepressant-like effects were evaluated in the forced-swim test 1-h, 1- and 3-day post-treatment. The rate of cell proliferation and the regulation of key neuroplasticity markers (FADD, Cdk5, p35, p25) involved in antidepressant-like responses in the hippocampus were evaluated 1-h, 1-day and 5-day post-treatment.

Results
Desipramine induced similar antidepressant-like effects in male and female rats (effective doses of 10 and 20 mg/kg, with effects that lasted up to 1-day post-treatment), without altering the rate of cell proliferation. However, some sex-differences emerged when evaluating neuroplasticity markers in the hippocampus, while no changes were observed for female rats, desipramine regulated FADD, Cdk-5 and p25 in males in a way that suggested neuroprotective actions.

Conclusions
Our findings imply that while desipramine induced similar antidepressant-like responses for male and female rats, some differences emerged in the regulation of certain neuroplasticity markers, suggesting that distinctive molecular mechanisms might be participating in the therapeutic response of desipramine for both sexes.
Outcome of pediatric chronic myeloid leukemia with management focusing on the monitoring of BCR-ABL fusion gene transcript levels
Authors: Al-Ghemlas Ibrahim , Al-Daama Saad , Aqueel Hawazin , Siddiqui Khawar , El-Solh Hassan , Omer Hala , AlRajeh Loloah , Al-Seraihy Amal , Alahmari Ali , AlSaedi Hawazen , AlAnazi Awatif , Ayas Mouhab 
Published: June 2022

Background and objective:
Clinical, laboratory and outcome data were reviewed for pediatric patients who were diagnosed with chronic myeloid leukemia (CML) and managed at two tertiary care hospitals in Saudi Arabia, between January 2011 and December 2017 to assess the response to tyrosine kinase inhibitors (TKI) focusing on the monitoring of BCR-ABL fusion gene transcript levels and to look at the overall outcome.

Methods:
CML patients were identified based on the cytogenetic and molecular results.

Results:
Twelve pediatric patients diagnosed with CML at a median age of 8.4 year; treated with TKI as first-line therapy, 11 (91.7%) patients were started with imatinib (first-generation TKI), while one received dasatinib (second-generation TKI) due to his three-way Philadelphia chromosome sensitivity. Eight patients (72.7%) starting on imatinib were switched to dasatinib (six patients due to drug resistance, and two patients due to intolerance of Imatinib) and two patients (25%) of whom had already achieved major molecular response (MMR) on Imatinib. Response rate to imatinib in terms of achieving MMR as first-line therapy was achieved in five out of 11 patients (45.5%) and only three of them continued to maintain their MMR. Six out of eight patients who were switched to dasatinib achieved MMR. Two patients underwent hematopoietic stem cell transplant (SCT): one due to blast crisis and one due to the side effects of TKI. With a median follow-up time of 78 months (range, 40.5–108), all of our patients were alive at last update.

Conclusion:
We report an excellent outcome with an overall survival (OS) of 100% at 5-year and disease- free survival (DFS) of 91.7% (8.0%). All our patients achieved MMR and only one patient had loss of MMR on follow-up. Eight patients (66.7%) achieved complete molecular response (CMR).
Guidance for Materials 4.0 to interact with a digital twin
Authors: Cogswell Daniel , Paramatmuni Chaitanya , Scotti Lucia , Moffat James 
Published: June 2022

Abstract
The rapid development of new infrastructure programmes requires an accelerated deployment of new materials in new environments. Materials 4.0 is crucial to achieve these goals. The application of digital to the field of materials has been at the forefront of research for many years, but there does not exist a unified means to describe a framework for this area creating pockets of development. This is confounded by the broader expectations of a digital twin (DT) as the possible answer to all these problems. The issue being that there is no accepted definition of a component DT, and what information it should contain and how it can be implemented across the product lifecycle exist. Within this position paper, a clear distinction is made between the “manufacturing DT” and the “component DT”; the former being the starting boundary conditions of the latter. In order to achieve this, we also discuss the introduction of a digital thread as a key concept in passing data through manufacturing and into service. The stages of how to define a framework around the development of DTs from a materials perspective is given, which acknowledges the difference between creating new understanding within academia and the application of this knowledge on a per-component basis in industry. A number of challenges are identified to the broad application of a component DT; all lead to uncertainty in properties and locations, resolving these requires judgments to be made in the provision of safety-dependent materials property data.
THE WEAK VOPĚNKA PRINCIPLE FOR DEFINABLE CLASSES OF STRUCTURES
Authors: BAGARIA JOAN , WILSON TREVOR M. 
Published: June 2022

AbstractWe give a level-by-level analysis of the Weak Vopěnka Principle for definable classes of relational structures (
$\mathrm {WVP}$
), in accordance with the complexity of their definition, and we determine the large-cardinal strength of each level. Thus, in particular, we show that
$\mathrm {WVP}$
for
$\Sigma _2$
-definable classes is equivalent to the existence of a strong cardinal. The main theorem (Theorem 5.11) shows, more generally, that
$\mathrm {WVP}$
for
$\Sigma _n$
-definable classes is equivalent to the existence of a
$\Sigma _n$
-strong cardinal (Definition 5.1). Hence,
$\mathrm {WVP}$
is equivalent to the existence of a
$\Sigma _n$
-strong cardinal for all
$n<\omega $
.
Preemergence and postemergence spiny amaranth (Amaranthus spinosus) and common lambsquarters (Chenopodium album) control in lettuce on organic soils
Authors: Odero D. Calvin , Wright Alan L. 
Published: June 2022

AbstractSuccessful weed management, particularly use of chemical control, is very important for commercial lettuce production on organic soils in the Everglades Agricultural Area in south Florida. Field experiments were conducted in 2016 and 2017 to determine the efficacy of herbicides (pronamide, bensulide, imazethapyr, or oxyfluorfen) applied preemergence (PRE) either alone or followed by a postemergence (POST) application of imazethapyr for weed control and lettuce (romaine and iceberg) yield. Preemergence-applied oxyfluorfen (0.56 kg ha−1) resulted in significant lettuce injury, including stand loss, while PRE applications of pronamide (4.44 kg ha−1), bensulide (5.6 and 10.1 kg ha−1), or imazethapyr (0.035 g ha−1) resulted in transient lettuce injury and no significant stand loss. Similarly, PRE-applied pronamide, bensulide, and imazethapyr followed by POST-applied imazethapyr did not result in significant lettuce stand loss or injury. When contrasted as a group, PRE-applied herbicides followed by a POST application of imazethapyr provided better spiny amaranth and common lambsquarters control compared with PRE-applied herbicides or POST-applied imazethapyr-only treatments. Lettuce yield was highest with PRE herbicides followed by POST imazethapyr compared with PRE herbicides or POST-applied imazethapyr-only treatments, indicating a yield benefit of having a PRE followed by POST herbicide weed control program in lettuce grown on organic soils. However, oxyfluorfen is not an option for lettuce on organic soils because of unacceptable stand reduction and crop injury. Whether to apply pronamide, bensulide, or imazethapyr PRE followed by a POST application of imazethapyr for broadleaf weed control in lettuce on organic soils depends on the species present, cost, and ease of application.
A Song of Wind and Ice: Increased Frequency of Marine Cold‐Spells in Southwestern Patagonia and Their Possible Effects on Giant Kelp Forests
Authors: Mora‐Soto A. , Aguirre C. , Iriarte J. L. , Palacios M. , Macaya E. C. , Macias‐Fauria M. 
Published: June 2022

AbstractIn contrast to other coastal regions of the world, the giant kelp (Macrocystis pyrifera) ecosystem in southwestern Patagonia has been persistent in area and associated biodiversity in the last decades. In this ecoregion, sea surface temperature (SST) records have consistently remained below the upper thermal threshold for kelp survival, however, no studies have analyzed the spatiotemporal variability of SSTs and their anomalies across the geographical diversity of the southwestern Patagonian coastline. We explored the geographical distribution of extreme warm and cold events in this region from latitudes 47°–56°S in a range of ∼1,000 km, identifying the dates and spatial distribution of marine heatwaves (MHWs) and marine cold‐spells (MCSs) from 1982 to 2020. Results show that a peak in the number of MHWs occurred in the great El Niño year of 1998. Additionally, the 2014–2019 period has had more severe and extreme MCSs than the previous decades. We discuss the origin of these events with a focus on three main processes: (a) geographically constrained cold events caused by glacier melting, (b) regional cold events caused by extreme winds linked to the position of the polar front, and (c) extensive SST anomalies linked to planetary‐scale events such as El Niño and La Niña. Overall, those processes were conductive to counteract global warming trends locally/regionally, highlighting southwestern Patagonia as a possible climatic refugium for the giant kelp ecosystem. Despite this, the effects of freshwater inputs and storm turbulence on the exposed coasts facing the Southern Ocean may cause new kinds of stress on this ecosystem.
Histone demethylase KDM4C is a functional dependency in JAK2-mutated neoplasms
Authors: Ernst Philipp , Schnöder Tina M. , Huber Nicolas , Perner Florian , Jayavelu Ashok Kumar , Eifert Theresa , Hsu Chen-Jen , Tubío-Santamaría Nuria , Crodel Carl C. , Ungelenk Martin , Hübner Christian A. , Clement Joachim H. , Hochhaus Andreas , Heidel Florian H. 
Published: June 2022

AbstractMutations of the JAK2 gene are frequent aberrations in the aging hematopoietic system and in myeloid neoplasms. While JAK-inhibitors efficiently reduce hyperinflammation induced by the constitutively active mutated JAK2 kinase, the malignant clone and abundance of mutated cells remains rather unaffected. Here, we sought to assess for genetic vulnerabilities of JAK2-mutated clones. We identified lysine-specific demethylase KDM4C as a selective genetic dependency that persists upon JAK-inhibitor treatment. Genetic inactivation of KDM4C in human and murine JAK2-mutated cells resulted in loss of cell competition and reduced proliferation. These findings led to reduced disease penetrance and improved survival in xenograft models of human JAK2-mutated cells. KDM4C deleted cells showed alterations in target histone residue methylation and target gene expression, resulting in induction of cellular senescence. In summary, these data establish KDM4C as a specific dependency and therapeutic target in JAK2-mutated cells that is essential for oncogenic signaling and prevents induction of senescence.
Changes in adiponectin:leptin ratio among older adults with obesity following a 12-month exercise and diet intervention
Authors: Senkus Katelyn E. , Crowe-White Kristi M. , Bolland Anneliese C. , Locher Julie L. , Ard Jamy D. 
Published: June 2022

Abstract
Background
Excess adiposity is characterized by alterations in adipokine secretion such that circulating leptin concentrations are increased with reductions in adiponectin. An emerging biomarker for the assessment of this adipose tissue (AT) dysfunction is the adiponectin:leptin (AL) ratio. A low AL ratio may be suggestive of dysfunctional AT and, consequently, a heightened cardiometabolic disease risk. This ancillary study investigated the relationship between the AL ratio and cardiometabolic health among community-dwelling older adults with obesity, as well as the effects of a 12-month exercise and diet intervention on changes in the AL ratio.

Methods
Participants (n = 163, 70.2 ± 4.7 years, 38.0% male) were randomized to the exercise only group, exercise + nutrient-dense weight maintenance group (exercise + weight maintenance), or exercise + nutrient-dense caloric restriction of 500 kcal/d group (exercise + intentional weight loss) (clinicaltrials.gov #NCT00955903). Total and regional adiposity as determined by magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry (DXA), anthropometrics, and cardiometabolic biomarkers were assessed at baseline and 12 months.

Results
The AL ratio was significantly (p < 0.05) inversely correlated with body mass index, waist circumference, measures of adiposity, and insulin among all participants at baseline. Among females only, significant positive and inverse correlations were also observed between this ratio and high-density lipoprotein cholesterol and the inflammatory biomarkers high sensitivity C-reactive protein and interleukin-6, respectively. While controlling for biological sex, a significant time by intervention group interaction effect (p < 0.05) was observed such that the AL ratio significantly increased from baseline to study completion among participants in the exercise + weight maintenance group and exercise + intentional weight loss group. Post hoc analysis revealed that the exercise + intentional weight loss group exhibited a significantly greater AL ratio at study completion compared to other groups (p < 0.05 all).

Conclusions
Results are in support of the AL ratio as a measure of AT dysfunction among older adults. Furthermore, results suggest that a 12-month exercise and diet intervention with intentional weight loss assists in improving the AL ratio in this population.
Harnessing solar power: photoautotrophy supplements the diet of a low-light dwelling sponge
Authors: Hudspith Meggie , de Goeij Jasper M , Streekstra Mischa , Kornder Niklas A , Bougoure Jeremy , Guagliardo Paul , Campana Sara , van der Wel Nicole N , Muyzer Gerard , Rix Laura 
Published: June 2022

Abstract
The ability of organisms to combine autotrophy and heterotrophy gives rise to one of the most successful nutritional strategies on Earth: mixotrophy. Sponges are integral members of shallow-water ecosystems and many host photosynthetic symbionts, but studies on mixotrophic sponges have focused primarily on species residing in high-light environments. Here, we quantify the contribution of photoautotrophy to the respiratory demand and total carbon diet of the sponge Chondrilla caribensis, which hosts symbiotic cyanobacteria and lives in low-light environments. Although the sponge is net heterotrophic at 20 m water depth, photosynthetically fixed carbon potentially provides up to 52% of the holobiont’s respiratory demand. When considering the total mixotrophic diet, photoautotrophy contributed an estimated 7% to total daily carbon uptake. Visualization of inorganic 13C- and 15N-incorporation using nanoscale secondary ion mass spectrometry (NanoSIMS) at the single-cell level confirmed that a portion of nutrients assimilated by the prokaryotic community was translocated to host cells. Photoautotrophy can thus provide an important supplemental source of carbon for sponges, even in low-light habitats. This trophic plasticity may represent a widespread strategy for net heterotrophic sponges hosting photosymbionts, enabling the host to buffer against periods of nutritional stress.
Hierarchical micro/nanostructured silver hollow fiber boosts electroreduction of carbon dioxide
Authors: Li Shoujie , Chen Wei , Dong Xiao , Zhu Chang , Chen Aohui , Song Yanfang , Li Guihua , Wei Wei , Sun Yuhan 
Published: June 2022

AbstractEfficient conversion of CO2 to commodity chemicals by sustainable way is of great significance for achieving carbon neutrality. Although considerable progress has been made in CO2 utilization, highly efficient CO2 conversion with high space velocity under mild conditions remains a challenge. Here, we report a hierarchical micro/nanostructured silver hollow fiber electrode that reduces CO2 to CO with a faradaic efficiency of 93% and a current density of 1.26 A · cm−2 at a potential of −0.83 V vs. RHE. Exceeding 50% conversions of as high as 31,000 mL · gcat−1 · h−1 CO2 are achieved at ambient temperature and pressure. Electrochemical results and time-resolved operando Raman spectra demonstrate that enhanced three-phase interface reactions and oriented mass transfers synergistically boost CO production.
Towards artificial general intelligence via a multimodal foundation model
Authors: Fei Nanyi , Lu Zhiwu , Gao Yizhao , Yang Guoxing , Huo Yuqi , Wen Jingyuan , Lu Haoyu , Song Ruihua , Gao Xin , Xiang Tao , Sun Hao , Wen Ji-Rong 
Published: June 2022

AbstractThe fundamental goal of artificial intelligence (AI) is to mimic the core cognitive activities of human. Despite tremendous success in the AI research, most of existing methods have only single-cognitive ability. To overcome this limitation and take a solid step towards artificial general intelligence (AGI), we develop a foundation model pre-trained with huge multimodal data, which can be quickly adapted for various downstream cognitive tasks. To achieve this goal, we propose to pre-train our foundation model by self-supervised learning with weak semantic correlation data crawled from the Internet and show that promising results can be obtained on a wide range of downstream tasks. Particularly, with the developed model-interpretability tools, we demonstrate that strong imagination ability is now possessed by our foundation model. We believe that our work makes a transformative stride towards AGI, from our common practice of “weak or narrow AI” to that of “strong or generalized AI”.
Genome-wide association analysis and replication in 810,625 individuals with varicose veins
Authors: Ahmed Waheed-Ul-Rahman , Kleeman Sam , Ng Michael , Wang Wei , Auton Adam ,   23andMe Research Team, Agee Michelle , Aslibekyan Stella , Bell Robert K. , Bryc Katarzyna , Clark Sarah K. , Elson Sarah L. , Fletez-Brant Kipper , Fontanillas Pierre , Furlotte Nicholas A. , Gandhi Pooja M. , Heilbron Karl , Hicks Barry , Hinds David A. , Huber Karen E. , Jewett Ethan M. , Jiang Yunxuan , Kleinman Aaron , Lin Keng-Han , Litterman Nadia K. , Luff Marie K. , McCreight Jennifer C. , McIntyre Matthew H. , McManus Kimberly F. , Mountain Joanna L. , Mozaffari Sahar V. , Nandakumar Priyanka , Noblin Elizabeth S. , Northover Carrie A. M. , O’Connell Jared , Petrakovitz Aaron A. , Pitts Steven J. , Poznik G. David , Sathirapongsasuti J. Fah , Shastri Anjali J. , Shelton Janie F. , Shringarpure Suyash , Tian Chao , Tung Joyce Y. , Tunney Robert J. , Vacic Vladimir , Wang Xin , Zare Amir S. , Lee Regent , Handa Ashok , Zondervan Krina T. , Wiberg Akira , Furniss Dominic 
Published: June 2022

AbstractVaricose veins affect one-third of Western society, with a significant subset of patients developing venous ulceration, costing $14.9 billion annually in the USA. Current management consists of either compression stockings, or surgical ablation for more advanced disease. Most varicose veins patients report a positive family history, and heritability is ~17%. We describe the largest two-stage genome-wide association study of varicose veins in 401,656 individuals from UK Biobank, and replication in 408,969 individuals from 23andMe (total 135,514 cases and 675,111 controls). Forty-nine signals at 46 susceptibility loci were discovered. We map 237 genes to these loci, several of which are biologically plausible and tractable to therapeutic targeting. Pathway analysis identified enrichment in extracellular matrix biology, inflammation, (lymph)angiogenesis, vascular smooth muscle cell migration, and apoptosis. Using a polygenic risk score (PRS) derived in an independent cohort, we demonstrate its predictive utility and correlation with varicose veins surgery.
Nonlinear two-level dynamics of quantum time crystals
Authors: Autti S. , Heikkinen P. J. , Nissinen J. , Mäkinen J. T. , Volovik G. E. , Zavyalov V. V. , Eltsov V. B. 
Published: June 2022

AbstractA time crystal is a macroscopic quantum system in periodic motion in its ground state. In our experiments, two coupled time crystals consisting of spin-wave quasiparticles (magnons) form a macroscopic two-level system. The two levels evolve in time as determined intrinsically by a nonlinear feedback, allowing us to construct spontaneous two-level dynamics. In the course of a level crossing, magnons move from the ground level to the excited level driven by the Landau-Zener effect, combined with Rabi population oscillations. We demonstrate that magnon time crystals allow access to every aspect and detail of quantum-coherent interactions in a single run of the experiment. Our work opens an outlook for the detection of surface-bound Majorana fermions in the underlying superfluid system, and invites technological exploitation of coherent magnon phenomena – potentially even at room temperature.