bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of neuroprotective activity of new acetylcholinesterase inhibitors TVA and TVS in experimental model of Alzheimer’s disease
Authors: Gasparyan Hrachik V. , Buloyan Sona A. , Harutyunyan Hayk A. , Pogosyan Anahit E. , Arshakyan Lilit M. , Harutyunyan Lusine S. , Avetisyan Zubeida A. , Tosunyan Syuzanna R. , Hovhannisyan Armen A. , Topuzyan Vigen O. 
Published: November 2022

Introduction: Alzheimer’s disease (AD) is a severe neurodegenerative disease characterized by loss of synaptic connection between neurons of the cortex and subcortical regions. The cholinergic deficit is a consistent and early finding in AD, hence acetylcholinesterase inhibitors (AChEIs) are used for symptomatic improvement of AD. Most of these therapeutic agents are hepatotoxic, leading to liver failure and other complications. Therefore, the study of new AChEIs with less toxic impact and better effectivity is a topical challenge. In view of this, we synthesized novel chemical compounds: TVA and TVS that possess AChEI activity and studied their neuroprotective effect in an experimental AD model.
Materials and methods: Studies were performed on white rats. Acute toxicity studies were performed by Karber’s method. AD was induced via bilateral intracerebroventricular administration of Aβ 25–35. Histopathological examinations were performed in the hippocampus and the entorhinal cortex. Liver tissue was additionally examined to monitor the hepatotoxicity of these compounds.
Results: Studies of the hippocampus showed that compared to control and TVA-treated groups, under the influence of TVS there were few morphological alterations. Experimental groups showed an increase in the glial cell count, compared to the intact animals. In comparison to the AD group, the increase in microglia was not that prominent under the action of the novel compounds. Under the influence of TVA and TVS, the entorhinal cortex was more susceptible to neuronal injury, although TVS protected pyramidal neurons. Also, the group treated with TVA had signs of acute liver damage, while under the influence of TVS there were no signs of liver changes.
Discussion: Histopathological examination showed that the neurodegenerative processes in the hippocampus, as well as in the entorhinal cortex, were significantly reduced under the influence of TVS, compared with the control group. At the same time, TVA had no significant effect on the protection of neuronal cells. Also, TVS was less toxic, and there was no sign of hepatotoxicity during the experiments.
Conclusion: These studies demonstrated that TVS possesses neuroprotective activity and reduces neuronal damage induced by Aβ.
Graphical abstract:
Factors Influencing Nurses' Behavior in Nutritional Care for Community-Dwelling Older Adults Before, During, and After Hospitalization: A Delphi Study
Authors: ten Cate Debbie , Schuurmans Marieke J. , van Eijk Jorna , Bell Jack J. , Schoonhoven Lisette , Ettema Roelof G. A. 
Published: November 2022

Background
To improve nutritional care for community-dwelling older adults before, during, and after hospitalization, factors influencing nurses' current behavior should be targeted. The aim of this study was to obtain expert consensus on which factors influencing the behavior of hospital and home care nurses are most relevant, modifiable, and feasible to influence.

Method
In a two-round Delphi study, nine pre-selected factors were rated by 26 experts.

Results
Eight factors were rated as relevant, modifiable, and feasible to influence: (1) lack of sufficient knowledge, (2) mainly neutral attitude, (3) low prioritization, (4) ambiguous motivation to routinely use guidelines and screening tools, (5) moderate awareness about risk factors, (6) lack of sense of involving informal caregivers, (7) ambiguous motivation to follow education and training, and (8) strong focus on medical nutrition.

Conclusion

The expert panel reached consensus on eight factors influencing nurses' current behavior. To enhance nutritional care to prevent malnutrition in older adults, strategies are needed for targeting these factors in nursing practice, education, and research.

[
J Contin Educ Nurs
. 2022;53(12):545–556.]
CLR: Cloud Linear Regression Environment as a More Effective Resource-Task Scheduling Environment (State-of-the-Art)
Authors: Seno Mohammed E. , Mohammad Omer K. Jasim , Dhannoon Ban N. 
Published: November 2022

The cloud paradigm has swiftly developed, and it is now well known as one of the emerging technologies that will have a significant influence on technology and society in the next few years. Cloud computing also has several benefits, including lower operating costs, server consolidation, flexible system setup, and elastic resource supply. However, there are still technological hurdles to overcome, particularly with real-time applications by providing resources. Resources allocation management most charming part of cloud computing; therefore, several authors have worked in the area of resource usage. This study introduces an innovative cloud machine learning framework-based linear regression approach called cloud linear regression (CLR), which entails both cloud technology and machine learning concept. CLR using machine learning yielded good prediction results for resource allocation management, as appeared with many researching, and still seek, research to raise optimal solutions to the resources' allocation problem as the aim of this study. This study discusses the relation between cloud resource allocation management and machine learning techniques by illustrating the role of linear regression methods, resource distribution, and task scheduling. The analytical analysis shows that the CLR promises to present an effective solution for resources (scheduling, provisioning, allocation, and availability).
RBHE em tempos de celebração, perplexidades e retrocessos
Authors: Vieira Carlos Eduardo , Galak Eduardo Lautaro , Gondra José Gonçalves , Medeiros Neta Olívia Morais de , Campos Raquel Discini de 
Published: November 2022

O ano em que se comemora o Bicentenário da Independência do Brasil pode ser tomado como um marcador importante para se pensar inúmeras iniciativas voltadas para a construção da nação. Uma delas se refere precisamente ao mundo dos impressos, o que também ajuda a nos afastar e problematizar a historiografia que reduz o complexo processo da emancipação do Brasil a uma cena, um homem, uma data e um enunciado imperativo. Como se sabe, a partir da transferência e necessidade da Corte portuguesa de se comunicar com os súditos, diversos e distribuídos desigualmente no vasto território do Brasil, D. João VI autorizou a criação da Impressão Régia.
A primeira tipografia brasileira publicou alguns livros e decretos até que, em 10 de setembro de 1808, lançou a Gazeta do Rio de Janeiro, considerada a primeira publicação impressa seriada realizada no Brasil. Depois, outras tipografias foram instaladas em outras regiões e, paulatinamente, o Brasil foi ingressando naquilo que Anderson (2008) designou de "capitalismo tipográfico". A partir de então, é possível observar, efetivamente, a proliferação da publicação de panfletos, jornais, revistas, relatórios, anuários e livros. Essa produção impressa variava tanto em termos de conteúdo, projeto editorial, formatos e destinatários. É igualmente possível observar que os responsáveis, isto é, os editores também apresentavam (e apresentam) pertencimentos os mais diversos; o que reforça a percepção do caráter estratégico da palavra impressa e das disputas no campo da comunicação social, da construção da opinião pública, mais ou menos especializada/especializante, pela ação de selecionar, priorizar e disseminar alguns acontecimentos sociais, de modos bem determinados, a ponto de ser considerada o “quarto poder”, confirmando a máxima da inexistência de poder sem imprensa e de imprensa sem poder.
PELAKSANAAN PENANGANAN KREDIT MACET DENGAN MEMAKAI JAMINAN HAK TANGGUNGAN PADA PT. BANK RAKYAT INDONESIA, (Persero), Tbk, CABANG GATOT SUBROTO
Authors: Telaumbanua Yasa Aro , Panjaitan Nata Perdamean , Devi Ria Sintha , Yasid Muhammad 
Published: November 2022

Bagi perbankan, setiap pemberian kredit yang disalurkan kepada pengusaha selalu mengandung resiko. Oleh karena itu, perlu unsur pengamanan (safety) sebagai salah satu prinsip dasar dalam peminjaman kredit selain unsur keserasian (suitability) dan keuntungan (profitability). Studi ini bertujuan untuk menganalisis proses kredit dengan memakai jaminan hak tanggungan oleh debitur di PT. BRI Cabang Gatot Subroto Medan; faktor penyebab

kredit macet PT. Bank Rakyat Indonesia, Tbk, Cabang Gatot Subroto Medan dan penyelesaian kredit macet dengan memakai jaminan hak tanggungan. Metode penelitian yang dipakai adalah Yuridis Normatif yaitu mengkaji peraturan perundang-undangan dengan menggunakan Undang-undang Nomor 10 Tahun 1998 tentang Perbankan. Didalam prakteknya calon debitur mengajukan permohonan pinjaman kepada bank dengan menyertakan segala bentuk surat-surat, yaitu identitas peminjam, jaminan pinjaman berupa Akta Kepemilikan atas Tanah dan Bangunan serta surat-surat perizinan usaha jika Debiturnya adalah badan hukum.Jika menurut Bank permohonan yang diajukan oleh Debitur memenuhi kriteria, maka terjadilah kesepakatan pemberian Fasilitas Kredit (Bank Konvensional) atau Pembiayaan (Bank Syariah) kepada Debitur. Tindak lanjut dari kesepakatan pinjam meminjam tersebut, bank memberikan sejumlah dana (uang) sebagai bentuk pinjaman kepada Debitur, kemudian Debitur memberikan surat-surat kepemilikan tanah/bangunan ataupun benda lainnya sebagai jaminan pelunasan pinjaman. Jaminan berupa tanah dan bangunan biasanya dibebani dengan pemasangan Sertifikat Hak tanggungan yang diterbitkan oleh Badan Pertanahan Nasional (BPN). Dari kesepakatan Fasilitas Kredit tersebut, Bank memberikan syarat kewajiban agar Debitur membayar pinjaman/kredit dengan sistem angsuran/cicilan setiap bulan dengan tenggang waktu pelunasan antara 1 (satu) s/d 20 (dua puluh) tahun. Apabila Debitur melakukan pembayaran angsurannya secara tepat waktu sampai dengan adanya pelunasan, maka Bank tentu akan memberikan penilaian bahwa Debitur tersebut adalah debitur/nasabah dengan predikat baik, sehingga kemudian Bank akan lebih percaya untuk kembali memberikan pinjaman kepada Debitur dengan predikat baik tersebut.
PERAN KOMUNIKASI ORGANISASI DAN GAYA KEPEMIMPINAN TERHADAP LOYALITAS KARYAWAN DI PERUSAHAAN, CABANG PEKAN BARU
Authors: Ginting Emmelia Arihta , Bangun Daniel P. 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui peranan pelaksanaan komunikasi organisasi dan gaya kepemimpinan terhadap loyalitas karyawan di Perusahaan Transport Cabang Pekan Baru di tahun 2018. Subjek penelitian adalah karyawan di kantor Cabang Pekan Baru sedangkan objek penelitian adalah Komunikasi Organisasi, Gaya Kepemimpinan dan Loyalitas Karyawan. Teori yang digunakan dalam penelitian meliputi teori komunikasi organisasi, gaya kepemimpinan transformasional, loyalitas karyawan, dan teori hubungan manusiawi yang dipergunakan sebagai pisau analisis dalam melihat permasalahan yang ada. Teknik pengumpulan data melalui penelitian di lapangan dengan menggunakan metode observasi dan wawancara mendalam dengan informan penelitian. Teknik Analisis Data menggunakan teknik pendekatan deskriptif kualitatif. Hasil analisis deskriptif menunjukkan bahwa pelaksanaan komunikasi organisasi di Perusahaan Transport, Cabang Pekan Baru, belum efektif. Hal ini disebabkan ketidaksiapan dalam pengelolaan pesan-pesan komunikasi dalam organisasi yang masih mengutamakan penggunaan metode lisan. Demikain juga ditemukan tidak ada penguatan pesan atau pesan yang tidak bersifat jaringan sehingga pesan organisasi sering putus di tengah jalan. Gaya kepemimpinan yang dilaksanakan masih jauh dari gaya kepemimpinan transformasional. Loyalitas karyawan terlihat mengalami penurunan yang diakibatkan gaya kepemimpinan yang tidak mampu mempengaruhi bawahan untuk merasakan kepercayaan, kebanggaan, loyalitas dan rasa hormat terhadap atasan serta termotivasi untuk melakukan lebih dari apa yang diharapkan. Sebaiknya menjadi perhatian penting perusahaan untuk meningkatkan kualitas pelaksanaan komunikasi organisasi di perusahaan, dengan memilih pimpinan yang mampu melaksanakan komunikasi organisasi yang baik melalui gaya kepemimpinannya sehingga perusahaan tetap mendapatkan dukungan berupa loyalitas dari seluruh karyawan-karyawan potensial yang merupakan asset perusahaan demi perkembangan dan kelangsungan perusahaan itu sendiri.
Polat Yöresi Gelin Türkülerinde Toplumsal Cinsiyete Dair İzler
Authors: ALPDOĞAN Fatih Furkan , SOLMAZ Fatih 
Published: November 2022

Toplumsal cinsiyet, kültürel kodlardan, değerlerden, inançlardan beslenir. Her kültür kendine özgü toplumsal cinsiyet stereotypleri geliştirmiştir. Bu durum ise bütün toplumlarda kadına ve erkeğe yönelik hazır ve basmakalıp yargıların gelişmesine sebep olmuştur. Toplumsal hayatta kadına erkek gözünden bakmak ataerkil toplumlardaki cinsiyet olgusunun anlaşılması açısından önem arz etmektedir. Türk toplumunun tarihsel serüveni göz önüne alındığında kadının erkekten ayrı ya da müstakil bir konuma hapsedildiği gibi bir yargıda bulunmak oldukça yanlıştır. Türklerin tarih sahnesine çıktığı günden bu yana kadınlar, erkeklerden sosyal rol boyutuyla farklılaşsa dahi kadınların yönetimsel ve idari işlerde sorumluluk üstlendiği görülür. İslamiyet’in kabulüyle beraber ise Arap ve Fars kültüründeki ögeler İslam inancının kendisi gibi lanse ettirildiği için kadına yönelik algı belirli yönleriyle yozlaşmış bu durum ise sözlü ve yazılı kültürde kendine yer bulmuştur. Bu çalışmada iki ağıt türkü üzerinden toplumun sosyolojisi ve toplumsal cinsiyet algısı irdelenecektir. Türk töresinde ve toplumsal hayatında ön planda olan kadının farklı kültürlerin etkisi nihayetinde nasıl ve ne şekilde değiştiği örneklem üzerinden gösterilmeye, irdelenmeye çalışılacaktır. Örnek olarak seçilen her iki türkü de eril tahakkümün kadın üzerinde ki yaptırımı ve izleri tespit edilecektir. Toplumsal cinsiyet kuramları açısından da değerlendirilmelerde bulunulup toplumsal normların kadına yüklediği görev ve sorumluluklar örnek seçilen/çözümlenen türküler üzerinden anlatılacaktır. Ayrıca söylemeye bağlı anlatı formlarından biri olan türküler toplumun sosyolojisinin çözümlenmesinde ki önemli bir anlatı olduğu da ortaya konulacaktır.
Association of Anterior Alveolar Dimensions with Different Sagittal Jaw Relationships
Authors: Abdul Jabbar  , Muhammad Nazir  , Maryam Mushtaq  , Romesa Khero  , Permanand  , Muzaffar Qayum Khan Ghouri  
Published: November 2022

and sagittal jaw relationship.
Methodology: This Cross-sectional study took place in Orthodontic Department, Institute of Dentistry, Liaquat University of Medical and Health Sciences, Jamshoro, from August 2018 to January 2019.
Patients of both genders ranging in age from 18 to 30 years were included. All the subjects, as per ANB angle, were grouped into three categories as (Class I = value between 1Â° and 4Â° for ANB angle), (Class II = value > 5Â° for ANB angle) and (Class III= value <1Â° for ANB angle). All the data was recorded in the Performa for the purpose of analysis.
Results: A total ofÂ 90 patients were studied; their average age was 21.12+3.47 years and 52.2% were females. Mean upper posterior alveolus width was significantly higher in sagittal class II as 12.69 Â± 5.52 than in sagittal class I and III p-value 0.058. The mean upper anterior alveolus height was found to be significantly greater in class I and III in contrast to class II p-value 0.028. Mean lower anterior alveolus width was insignificantly related with sagittal classification, p-value 0.343. Mean upper anterior alveolus width and lower posterior alveolus width were insignificantly related to sagittal classification, and the p-value were quite insignificant. Sagittal class II and III were significantly associated with female gender 0.021, while class I was linked to male gender p-value 0.021.
Conclusion:Â There was a significant association between dimensions of anterior alveolar among different vertical and sagittal jaw association.
Health-related quality of life as associated with asthma control, psychological status and insomnia
Authors: Rask-Andersen Anna , Leander Mai , Sundbom Fredrik , Lampa Erik , Oudin Anna , Leynaert Bénédicte , Svanes Cecilie , Gislason Thorarinn , Torén Kjell , Janson Christer 
Published: November 2022

Background: Asthma is associated not only with lower health-related quality of life (HRQL) but also with psychological health and insomnia. The aim of this study was to investigate associations between HRQL, asthma symptoms, psychological status and insomnia in adults from three Nordic countries.
Methods: This study comprised 2,270 subjects aged 29–55 from Sweden, Iceland and Norway. HRQL was measured with the 36-Item Short Form Health Survey (SF-36). The physical (PCS) and mental health (MCS) component scores were calculated with higher values, indicating better health status. Symptoms of depression and anxiety were measured using the Hospital Anxiety and Depression Scale (HADS). Insomnia was assessed with the Basic Nordic Sleep Questionnaire. An asthma score consisting of a sum of the positive answers to five respiratory symptoms was used in the analysis. Spirometry and allergy tests were also performed.
Results: High HADS and sleep disturbance scores were both related to a low PCS and MCS, respectively, after adjusting for confounders. High age and high body mass index (BMI) were associated with low scores on the PCS, whilst the opposite was found for the MCS. A higher asthma score was related to a low PCS. An interaction between the HADS and the asthma symptom score was observed for the PCS (P = 0.0002), where associations between psychological status and the PCS were more pronounced for individuals with more symptoms than for individuals without symptoms.
Conclusions: In this study, we found that HRQL of life was independently related to the HADS, insomnia and asthma symptoms. Further prospective studies to identify the most efficient target for intervention in order to improve asthma control are needed.
Hubungan Asupan Energi Protein, Status Penyakit Infeksi, dan Pendidikan Orang Tua dengan Kejadian Stunting pada Balita Usia 25-60 Bulan
Authors: Sitti Zakiyyah Putri  , Sitti Maryam Bachtiar  
Published: November 2022

Stunting merupakan pertumbuhan fisik tinggi badan yang tidak normal sesuai dengan umur. Stunting dipengaruhi oleh multifactor diantaranya adalah asupan energi, protein, status penyakit infeksi dan pendidikan orang tua.
Tujuan dari penelitian ini adalah untuk mengetahui hubungan asupan energi protein, status penyakit infeksi, dan pendidikan orang tua dengan kejadian stunting pada balita. Desain penelitian yang digunakan yaitu analitik observational dengan pendekatan cross sectional study. Populasi dalam penelitian ini yaitu seluruh balita usia 25-60 bulan yang ada di wilayah kerja Puskesmas Totoli yang berjumlah 98 balita. Teknik pengambilan sampel yang digunakan yaitu, yang pertama menggunakan cluster random sampling untuk pemilihan puskesmas kemudian yang kedua menggunakan consecutive sampling dengan jumlah sampel sebanyak 79 balita. Data dikumpulkan dengan menggunakan kuesioner. Analisis data menggunakan analisis person chi-square dan fisher’s exact test dengan α=0.05. Balita usia 25-60 bulan sebagian besar mengalami asupan energi dan protein yang rendah, status penyakit infeksi yang jarang terjadi, dan rata-rata pendidikan Ibu Rendah.
Kesimpulan Hasil Analisis ada hubungan yang bermakna antara asupan energi dengan kejadian stunting nilai p = 0.010 (p ˃ 0.05), ada hubungan yang bermakna antara asupan protein dengan kejadian stunting nilai p = 0.003 (p ˃ 0.05), tidak ada hubungan yang bermakna antara status penyakit infeksi dengan kejadian stunting nilai p = 1.000 (p ˃ 0.05), ada hubungan yang bermakna antara pendidikan orang tua dengan kejadian stunting pada nilai p = 0.013 (p ˃ 0.05) dengan kejadian stunting pada balita usia 25 – 60 bulan.
Saran bagi responden sebaiknya lebih meningkatkan pengetahuan terkait status gizi pada anak, utamanya dalam pemenuhan asupan energi, Protein dan faktor yang mempengaruhi status gizi anak dan dampak yang dapat terjadi karena kekurangan gizi. Sehingga responden mampu melakukan tindakan pencegahan terhadap status gizi buruk anak khususnya kejadian stunting. Hasil penelitian ini diharapkan dapat menjadi tambahan wawasan ilmu Asupan energi, Asupan Protein, Status penyakit infeksi, dan pendidikan orang tua terhadap kejadian stunting pada balita.
Pengaruh Konseling Dengan Pendekatan Thingking Feeling dan Acting terhadap Tekanan Darah pada Pasien Pre Operasi Katarak : Literature Review
Authors: Andi Safada  , Thalib Abdul Hermansyah , Irma Anjar Murni Samuda  
Published: November 2022

Berdasarkan data WHO, diperkirakan jumlah penderita katarak di dunia saat ini sekitar 17 juta orang dan diperkirakan akan meningkat menjadi 40 juta pada tahun 2020. Sementara di Indonesia prevalensi penderita katarak cenderung mengalami peningkatan. Operasi katarak merupakan salah satu cara menurunkan angka kejadian kasus namun tidak sedikit pasien post op katarak mengalami stres. Stres yang terjadi disebabkan oleh sensasi tekanan karena sedasi, risiko terjadinya infeksi, ketidaktahuan akan penyakit, ketidakpuasan terhadap tindakan operasi, dan terjadinya peningkatan denyut nadi serta laju pernapasan, sehingga akan mempengaruhi perkembangan kesehatan pasien. Salah satu latihan untuk menurunkan derajat tekanan darah adalah dengan pengaturan mental berupa thinking, feeling dan acting sehingga tekanan darah dapat teregulasi.
Tujuan penelitian adalah memberikan gambaran umum berbagai bukti dari penelitian-penelitian dahulu mengenai pengaruh konseling dengan pendekatan thingking feeling dan acting terhadap tekanan darah pada pasien pre operasi katarak.
Metode Penelitian ini menggunakan Pendekatan literature review yang bersumber dari tiga database penelitian, yaitu, PubMed, google scholar, dan garuda. Dengan beracun pada tahun publikasi 2011-2021, dan mengidentifikasi artikel yang layak direview berdasarkan kriteria inklusi dan eksklusi.
Hasil penelitian diperoleh 3 artikel yang dijadikan sebagai referensi utama dalam penyusunan literature review ini. Hasil penelitian menunjukkan konseling dengan pendekatan thingking feeling dan acting memberikan pengaruh terhadap tekanan darah pada pasien pre operasi katarak.
Kesimpulan Terdapat pengaruh konseling dengan pendekatan thingking feeling dan acting terhadap penurunan tekanan darah pada pasien pre operasi katarak