bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antihyperglycemic, Antihyperlipidemic, and Antioxidant Effects of Salvia
tingitana in Streptozotocin-Induced Diabetic Rats
Authors: Eddouks Mohamed , Azzane Amine 
Published: August 2022

Aims:
The study aimed to assess the antidiabetic effect of Salvia tingitana (S. tingitana).

Background:
S. tingitana is an aromatic plant that belongs to the Lamiaceae family. Phytochemical analysis of the aerial parts of S. tingitana revealed the existence of terpenoids and flavonoids. In addition, S. tingitana possesses antimicrobial activity.

Objective:
The goal of the study was to obtain information about the antihyperglycemic, antihyperlipidemic, antioxidant abilities of S. tingitana aqueous extract.

Material and Methods:
The effect of an acute and sub-chronic administration of S. tingitana aqueous extract (AEST) at the doses of 60 and 80 mg/kg on glucose, lipid profile, and lipoprotein profile was examined in normoglycemic and hyperglycemic rats. Additionally, a preliminary phytochemical screening, and the antioxidant activity using DPPH assay were carried out.

Results:
Rats treated with AEST at a dose of 60 mg/kg showed a significant decrease of the serum glucose levels during the single oral administration at the 4th and 6th hour of treatment in both normal and streptozotocin(STZ)-induced hyperglycemic rats. Interestingly, a dose of 80 mg/kg AEST produced a significant lowering effect on blood glucose levels at the 2nd, 4th, and 6th hour of treatment after a single oral administration in both diabetic and normal rats. Both doses of AEST (60 and 80 mg/kg) revealed a significant amelioration of lipid and lipoprotein profile. In addition, the qualitative and quantitative phytochemical analysis proved the presence of polyphenols compounds, flavonoids, and tannins. Results suggest that the S. tingitana contains some secondary metabolites like alkaloids, phenols, flavonoids, and saponins. Importantly, the study revealed that the aqueous extract of S. tingitana has a very interesting antioxidant activity (IC50 = 553.21 µg/ml).

Conclusion:
The study illustrates the beneficial action of the aqueous extract of S. tingitana as an antihyperglycemic and antihyperlipidemic agent.
Physicochemical Properties, Antioxidant and Antimicrobial Activities of Unripe Green and Ripened Yellow Banana (Musa sp.) Peel and Pulp Oil
Extracts
Authors: Dejene Workinesh , Yusuf Zekeria , Desta Mulugeta , Idris Megersa , Seyida Sultan , Dugasa Desta 
Published: August 2022

Background:
Banana peel (Musa Sp.) is more nutritional and rich in phytochemical
compounds than its pulp. All parts of the banana plant have medicinal applications. Damage from
free radicals at the cellular level causes cell inflammation, increasing the risk of damage from sunlight,
radiation, and related development of skin cancer.

Objective:
The purpose of this study was to assess the physicochemical properties, antioxidant, and
antimicrobial activities of unripe green and yellow ripened banana fruit peels and pulp oil extracts.

Methods:
The oil extraction was done in Soxhelt apparatus using petroleum ether as a solvent.
Then, the oil extracts were assessed based on the determination of oil yield, acid value, percent free
fatty acid, peroxide value, and free radical scavenging activity using 2, 2-diphenyl-1-picrylhydrazyl
(DPPH) and hydrogen peroxide, and ascorbic acid. The antioxidant and antimicrobial activities
were determined based on ascorbic acid content, DPPH and hydrogen peroxide scavenging activities.
The antimicrobial experiment was arranged in completely randomized factorial design with
three replications.

Results:
The result indicated that significantly the highest oil yield (2.60±0.21%), acid value
(2.66±0.20%), and free fatty acids (1.34±0.10%) were recorded for green peel oil extract. Significantly,
the highest DPPH radical scavenging activity was recorded for green peel (5.85%) followed by
green pulp (4.80) and the least for yellow peel (4.50). Ascorbic acid and hydrogen peroxide scavenging
activity were significantly higher for yellow peel and green pulp oil extract extracts than for green
peel oil extract. The strongest antibacterial activity with the maximum zone of inhibition (15.5mm),
minimum inhibitory concentration (0.125μg/ml), and corresponding minimum bactericidal concentration
(0.25 μg/ml) was recorded for ripened peel oil extract against Staphylococcus aureus. The antifungal
activity of the oil extract presented the highest zone of inhibition (15.67mm), minimum inhibitory
concentration (0.125 μg/ml) and corresponding minimum fungicidal concentration (0.25 μg/ml)
were recorded for unripe green banana fruit pulp oil extract against Aspergillus versicolor.

Conclusion:
The result indicated that the banana fruit peel oil extracts demonstrated differential antioxidant
and antimicrobial potentials. Thus, the banana peel waste oil extracts proved to have potential
sustainable applications in nutritional and drug development technologies.
Meditation Mobile App Developed for Patients With and Survivors of Cancer: Feasibility Randomized Controlled Trial
Authors: Huberty Jennifer , Bhuiyan Nishat , Puzia Megan , Joeman Lynda , Larkey Linda , Mesa Ruben 
Published: August 2022

Background
To address the unmet need for a commercial cancer-specific meditation app, we leveraged a long-standing partnership with a consumer-based app (ie, Calm) to develop the first commercial meditation app prototype adapted specifically for the needs of patients with cancer. Input was obtained at both the individual user and clinic levels (ie, patients with and survivors of cancer and health care providers).

Objective
This study aimed to determine the feasibility of a cancer-specific meditation app prototype.

Methods
Patients with and survivors of cancer who were recruited and enrolled in the feasibility randomized controlled trial were asked to use the prototype app daily (≥70 minutes per week) for 4 weeks. Participants completed web-based weekly questionnaires and a final poststudy questionnaire and were asked to participate in an optional web-based poststudy interview. The questionnaires and interviews covered the following feasibility categories: acceptability, demand, practicality, and adaptation.

Results
A total of 36 patients with and survivors of cancer completed the baseline questionnaire, 18 completed the final questionnaire, and 6 completed the optional interviews. Weekly and poststudy questionnaires indicated high overall enjoyment, ease of use, and satisfaction with the app content, aesthetics, and graphics. The objective use data indicated that the average total app use rate was 73.39 (SD 7.12) minutes per week. Interviews (N=6) revealed positive and mixed responses to the app prototype and informative differences related to preferences for narrators, emotional content, and meditation teaching but an overall appreciation for the variety of options.

Conclusions
The most likely candidates for moving from cancer-specific meditation apps to dissemination are through partnering with the industry, in which name recognition and market distribution are already established (even showing a base of users from the targeted population with cancer). This study established the feasibility of a cancer-specific mobile meditation app prototype for patients with and survivors of cancer, using a commercially available app. The quantitative and qualitative data demonstrated the acceptability, demand, practicality, and adaptation of the prototype. Improvements suggested by the participants will be considered in the final app design before testing the efficacy of the app in a future study.

Trial Registration
Clinicaltrials.gov NCT05459168; https://clinicaltrials.gov/ct2/show/record/NCT05459168
Clinical Study on Vitamin D deficiency in Hypothyroidism
Authors: PRIYA NEHA , KUMARI RINA , P WAGH SURAJ 
Published: August 2022

Vitamin D deficiency is a concern of global health nowadays. Although its main role is in regulating bone metabolism, over the past few decades, its impact on non-skeletal actions has been studied. Its role as an immune modulator has been recently emphasized. Recent evidence is increasingly pointed toward the significant role of vitamin D in reducing the incidence of autoimmune diseases. Aims & Objectives: In the present study, we aimed to determine the relationship between hypothyroidism and Vitamin D deficiency. Methods: It was an Observational Study, a study conducted in the Department of Biochemistry at MGM Medical College & LSK Hospital Kishanganj, Bihar. In the present study, 50 patients and 50 healthy age and sex-matched controls were included during the study period from June 2021 to March 2022. Serum vitamin D (25-OH) levels were measured in all the patients. Vitamin D deficiency was designated at levels lower than 20 ng/ml. Thyroid hormones (TSH, T3, and T4) were also evaluated in all participants. Results: Incidence of vitamin D deficiency is significantly high among hypothyroid patients compared to normal controls (p-value = 0.036). The mean level of Vitamin D was significantly low level among patients with hypothyroidism compared to controls (23.57 ±9.77 vs. 31.20 ±10.23 ng/ml, p-value =0.02). Pearson's correlation between vitamin D level and thyroid profile among hypothyroid cases revealed that there was a significant negative correlation between serum Vitamin D and TSH level (p-value = <0.0001). Conclusion: Deficiency of vitamin D is significantly associated with hypothyroidism, and therefore screening of vitamin D is essential for all hypothyroid patients.
Durkheim's Social Solidarity and the Division of labour: An Overview
Authors: Khairulyadi Khairulyadi , Ikramatoun Siti , Nisa Khairun 
Published: August 2022

This article aims to review Durkheim's concepts of division of labour and social solidarity, especially how social solidarity developed through the division of labour and how the interplay between the two gives rise to the functionality of the social system. This study, too, explains the relevance of such concepts to studying contemporary society. This study concludes that some underlying shortcomings need addressing without denying Durkheim's attempt to provide a sound methodological and theoretical foundation for sociology as a discipline. Durkheim's contention that the Division of labour forms social solidarity is deterministic and subscribes to the law of rigidity. Individuals' occupational function is seen as a determinant and therefore has nothing to do with human free will and individuals' subjectivity to meaning. It is a sort of reductionism because it eliminates the entire propensity of human nature. It reduces the conditions of society to that of the organism of a living being. As a result, it is tough to replicate Durkheim's solidarity model to explain the complex nature of current urban societies.
Abstrak
Artikel ini bertujuan untuk mendiskusikan konsep Durkheim tentang pembagian kerja dan solidaritas sosial, terutama bagaimana solidaritas sosial berkembang melalui pembagian kerja dan bagaimana interaksi antara keduanya memunculkan fungsi sistem sosial. Artikel ini juga menjelaskan relevansi konsep-konsep tersebut untuk mempelajari masyarakat kontemporer. Kajian ini menyimpulkan bahwa dalam konsep tersebut terdapat beberapa kekurangan mendasar perlu diatasi tanpa menyangkal fakta bahwa Durkheim telah memberikan landasan metodologis dan teoretis yang kuat untuk sosiologi sebagai suatu disiplin. Pendapat Durkheim bahwa pembagian kerja membentuk solidaritas sosial adalah deterministik dan menganut hukum kekakuan. Fungsi pekerjaan individu dipandang sebagai penentu dan karena itu tidak ada hubungannya dengan kehendak bebas manusia dan subjektivitas individu terhadap makna. Ini adalah semacam reduksionisme karena menghilangkan seluruh kecenderungan sifat manusia. Ia mereduksi kondisi masyarakat menjadi kondisi organisme makhluk hidup. Akibatnya, sulit untuk mengadaptasi model solidaritas Durkheim untuk menjelaskan sifat kompleks masyarakat perkotaan saat ini.
Teuku Riefky Harsya dan Pembangunan Pendidikan di Aceh
Authors: Samhudi Samhudi , Yunus Saifuddin , Nurdin Abidin 
Published: August 2022

Teuku Riefky Harsya, a member of the Aceh legislature from 2005-2024, has played a role in the development of education in Aceh. This article aims to explain two problems: Teuku Riefky Harsya's contribution to the development of education in Aceh and the political strategies used. The results showed that Teuku Rifky Harsya contributed to the development of education in Aceh, including the Smart Indonesia Program, Bidikmisi, Superior Scholarship, Infrastructure, Mobile library, and mobile cinema, healthy food for school children. Strategies for building education in Aceh are cross-party political communication, closeness with the ulama, teamwork, and forming field coordinators. Thus, education development in Aceh can continue to increase and benefit the community.
Abstrak
Teuku Riefky Harsya yang merupakan anggota legislatif Aceh dari tahun 2005-2024 yang telah berperan dalam pembangunan Pendidikan di Aceh. Artikel ini bertujuan untuk menjelaskan dua masalah yaitu; kontribusi Teuku Riefky Harsya dalam pembangunan pendidikan di Aceh dan strategi politik yang dipergunakan. Hasil penelitian menunjukkan bahwa Teuku Rifky Harsya memberikan kontribusi bagi perkembangan pendidikan di Aceh, antara lain: Program Indonesia Pintar, Bidikmisi, Beasiswa Unggul, Sarana Prasarana, Mobil perpustakaan dan bioskop keliling, makanan sehat untuk anak sekolah. Strategi dalam membangun pendidikan di Aceh yaitu komunikasi politik lintas partai, kedekatan dengan ulama, kerja sama tim dan membentuk koordinator lapangan. Sehingga dengan demikian pembangunan pendidikan di Aceh dapat terus meningkat dan dirasakan manfaatnya oleh masyarakat.
Perubahan Fungsi dan Kedudukan Meunasah dalam Kehidupan Generasi Muda Aceh
Authors: Azwarfajri Azwarfajri 
Published: August 2022

Meunasah underwent a drastic change in its function in the lives of the young generation of Aceh. Therefore, it is important to examine the changes in the function of the meunasah in the life activities of the young generation in seeing the urgency of the meunasah as a community center in supporting the development of young generations in the face of the globalization. This qualitative study uses interview methods, observation and documentation in collecting data and using interactive analysis in analyzing the findings. The results showed that the shift in the function of the meunasah in the young generation of Aceh was caused by social changes that occurred after the conflict and the tsunami disaster. This situation is strengthened by the condition of the meunasah that does not keep up with the development of information technology so that it is unable to answer the needs of the young generation who are bound by technology. Therefore, it is necessary to modernize the meunasah environment in order to meet the technological needs of the young generation, so that the meunasah can still function as a community center in preparing the young generation of Aceh.
Abstrak
Meunasah mengalami perubahan fungsi yang drastis dalam kehidupan generasi muda Aceh. Oleh karena itu menjadi penting untuk mengkaji tentang perubahan fungsi meunasah dalam aktivitas kehidupan generasi muda dalam melihat urgensitas meunasah sebagai community center dalam menopang perkembangan generasi muda dalam menghadapi globalisasi dunia. Penelitian kualitatif ini menggunakan metode wawancara, observasi dan dokumentasi dalam pengumpulan data dan menggunakan analisis interaktif dalam menganalisis temuan dalam penelitian ini. Hasil penelitian menunjukkan pergeseran fungsi meunasah dalam kehidupan generasi muda Aceh disebabkan oleh perubahan sosial yang terjadi pasca konflik dan bencana tsunami yang melanda Aceh. Kondisi ini dikuatkan dengan keadaan institusi meunasah yang tidak mengikuti perkembangan teknologi informasi sehingga tidak mampu menjawab kebutuhan hidup generasi muda yang terikat dengan teknologi. Oleh karena itu perlu dilakukan upaya modernisasi di lingkungan meunasah agar dapat memenuhi kebutuhan teknologi di kalangan generasi muda, sehingga meunasah tetap dapat difungsikan sebagai community center dalam menyiapkan generasi muda Aceh yang beriman dan berkemajuan.
Opportunities and Threats for Integration Cooperation within the Framework of the Union State of Belarus and Russia: Strategic Situational Analysis. Part 1
Authors: Bakhlova O. V. , Bakhlov I. V. 
Published: August 2022

Aims: identification of key factors of integration interaction within the internal dimension of the Union State of Belarus and Russia. Methods: informal substantive analysis of documents, formal legal method, SWOT analysis. Results and discussion: A set of internal factors of a system-wide nature, directly localized on the territory of the Union State, is investigated. These factors are interpreted as being of fundamental importance for ensuring the positive dynamics of Russian-Belarusian integration. The strengths and weaknesses of bilateral interaction are shown, taking into account theirinfluence, the results achieved and the likely directions of evolution in the context of the “restart” of integration, attributed to the autumn of 2021. The determinants of different levels of the discussion plan, including the motives of the power elites, are emphasized. Conclusion: The important advantages of the Union State, which distinguish it from other integration associations of the Commonwealth of Independent States region, are the multidimensionality, the coupling of different spheres of integration, the combination of axiological and utilitarian levers of integration. It has significant opportunities for progressive development in the future. However, there are also very tangible threats and risks of internal origin in the Union State. It is recommended to pay close attention to the elimination of internal vulnerabilities and the improvement of branding technologies and information support of the Union construction.
The Concept of Sustainable Development in the Projection of Modern Transformational Trends: A New Reality and New Opportunities for Business
Authors: Kuklina E. A. 
Published: August 2022

The relevance of the topic of the article is due to the importance of the concept of sustainable development for the successful functioning of enterprises in the new reality. The purpose of the article is to analyze the concept of sustainable development in the projection of modern transformational trends. Tasks: to consider the evolution of the conceptual provisions of sustainable development; perform an analysis of the UN sustainable development goals in the context of the formation of the “green” agenda; assess the impact of the digital transformation trend on sustainable development goals; identify new opportunities for implementing the concept in a new reality; identify ESG transformation risks and digital transformation risks. Methods. System approach, logical analysis, synthesis. Results. In modern conditions of the functioning of economic systems, sustainable development goals are a guideline for developing strategies not only at the state level, but also at the level of individual companies; ESG transformation is a new vector of business development. As a result of the development of globalization and the strengthening of the influence of transnational corporations, the focus of the concept of sustainable development has shifted from the national level to the corporate one. The general direction of the ESG approach to managing the development of economic systems at all levels will be set by international trends. To the greatest extent, the UN Sustainable Development Goals correlate with the social criterion (11 goals), while the environmental criterion and the criterion of corporate governance account for 8 goals each. Full coincidence in all ESG criteria is observed for two goals (“Industrialization, innovation and infrastructure; “Responsible consumption and production”). The most significant for companies in the short term are environmental and social risks; in the long term, the most significant criterion is “assessment of climate risks at the asset level”. When developing and implementing corporate strategies, it is necessary to take into account ESG risks, as well as possible threats to economic security (resource substitution, growth of intellectual property, cyberattacks, industrial espionage). Findings. The updated concept of sustainable development makes it possible to ensure economic growth when it is balanced with the needs of society to improve the quality of life, prevent degradation of the natural environment, but subject to ensuring safety and security.
Mental Maps of Strategic Alliances
Authors: Lapygin Yu. N. , Rozenkov M. A. 
Published: August 2022

The relevance of the tasks of building partnerships between organizations participating in the value chain, on the one hand, is determined by the desire to reduce transaction costs, and on the other hand, by the need to gain competitive advantages in the market of goods and services. The strategic intentions of interacting organizations are coordinated when formingalliances through agreements on mutual obligations. Such forms of association of organizations as meta-organizations, clusters and business ecosystems have their advantages and disadvantages. The purpose of this study is to determine the main content of these forms of association of participants in joint activities, which opens up the possibility of identifying distinctive features for adjusting the definitions of each of the forms. Among the research methods, models for constructing mental maps, the method of paired comparisons and the formation of blocks of characteristics, logical analysis and synthesis of information within the subject area of research were used. This paper defines the main content of these forms of association of organizations, as well as their advantages and disadvantages as initial categories. As a result, new definitions of these categories are given, as well as their interrelations, general and special characteristics.
Statistical analysis methods applied to early outpatient COVID-19 treatment case series data
Authors: Gkioulekas Eleftherios , McCullough Peter A , Zelenko Vladimir 
Published: August 2022

When confronted with a public health emergency, significant innovative
treatment protocols can sometimes be discovered by medical doctors at
the front lines based on repurposed medications. We propose a
statistical framework for analyzing the case series of patients treated
with such new protocols, that enables a comparison with our prior
knowledge of expected outcomes, in the absence of treatment. The goal of
the proposed methodology is not to provide a precise measurement of
treatment efficacy, but to establish the existence of treatment
efficacy, in order to facilitate the binary decision of whether the
treatment protocol should be adopted on an emergency basis. The
methodology consists of a frequentist component that compares a
treatment group against the probability of an adverse outcome in the
absence of treatment, and calculates an efficacy threshold that has to
be exceeded by this probability, in order to control the corresponding
$p$-value, and reject the null hypothesis. The efficacy threshold is
further adjusted with a Bayesian technique, in order to also control the
false positive rate. A random selection bias threshold is then
calculated from the efficacy threshold to control for random selection
bias. Exceeding the efficacy threshold establishes the existence of
treatment efficacy by the preponderance of evidence, and exceeding the
more demanding random selection bias threshold establishes the existence
of treatment efficacy by the clear and convincing evidentiary standard.
The combined techniques are applied to case series of high-risk COVID-19
outpatients, that were treated using the early Zelenko protocol and the
more enhanced McCullough protocol.