bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Descriptor Set for Quantitative Structure‐property Relationship Prediction in Biologics
Authors: Sankar Kannan , Trainor Kyle , Blazer Levi L. , Adams Jarrett J. , Sidhu Sachdev S. , Day Tyler , Meiering Elizabeth , Maier Johannes K. X. 
Published: March 2022

AbstractThere has been a remarkable increase in the number of biologics, especially monoclonal antibodies, in the market over the last decade. In addition to attaining the desired binding to their targets, a crucial aspect is the ‘developability’ of these drugs, which includes several desirable properties such as high solubility, low viscosity and aggregation, physico‐chemical stability, low immunogenicity and low poly‐specificity. The lack of any of these desirable properties can lead to significant hurdles in advancing them to the clinic and are often discovered only during late stages of drug development. Hence, in silico methods for early detection of these properties, particularly the ones that affect aggregation and solubility in the earlier stages can be highly beneficial. We have developed a computational framework based on a large and diverse set of protein specific descriptors that is ideal for making liability predictions using a QSPR (quantitative structure‐property relationship) approach. This set offers a high degree of feature diversity that may coarsely be classified based on (1) sequence (2) structure and (3) surface patches. We assess the sensitivity and applicability of these descriptors in four dedicated case studies that are believed to be representative of biophysical characterizations commonly employed during the development process of a biologics drug candidate. In addition to data sets obtained from public sources, we have validated the descriptors on novel experimental data sets in order to address antibody developability and to generate prospective predictions on Adnectins. The results show that the descriptors are well suited to assist in the improvement of protein properties of systems that exhibit poor solubility or aggregation.
MIMO antenna performance with isolator
Authors: Lee Hoseung , Jeon Jihwan , Park Donghee , Shin Hyunwoong , Kim Hyeongdong 
Published: March 2022

AbstractIn this article, the effect of an isolator in a multiple‐input multiple‐output (MIMO) antenna is analyzed in terms of its efficiency and isolation. An isolator is frequently utilized in MIMO antennas; however, the use of an isolator can aggravate the bandwidth or efficiency performance even though its isolation performance is improved. To develop a way of applying an isolator without sacrificing the bandwidth or efficiency performance, it is important to note that the characteristic modes excited by the MIMO antenna are related to the performance of the isolator. Two MIMO antenna systems using different ground characteristic modes are implemented to analyze the effect of the isolator. Via the isolator, both MIMO antennas achieved improved isolation, but the reference antenna underwent severe bandwidth degradation and efficiency degradation (from 31.81% to 16.69%), whereas the proposed antenna had relatively smaller reductions in bandwidth and efficiency (from 53.14% to 46.87%).
Cavity dynamics of a hybrid mode‐locked figure of eight fiber laser
Authors: Iqbal Muddassir , Yuze Wu , Youqiao Ma , Ullah Sibghat , Min Lai , Delin Zhao , Mao Yaya 
Published: March 2022

AbstractMode‐locking is an increased focus area due to the augmented requirement of ultra‐short and high‐intensity optical pulses for varied applications. Tunable mode‐locked lasers capable of operating in the infrared range at high repetition frequency brought innovative opportunities for insensitive and accurate laser surgery. As one important application of optical pulse propagation in an optical fiber, we have discussed a dual‐ring hybrid mode‐locked fiber laser using modulator, and saturable absorber. The active mechanism, saturable absorber, and the nonlinear optical loop mirror result in an output with a peak power of 16 dBm, and 80 fs full‐width at half‐maximum with a high duty cycle. It occupies a small space and is easy to achieve miniaturization and intensification; the laser output can be adjusted by varying multiple parameters such as pump, input, doped fiber length, modulator (including modulation signal), saturable absorber, and other devices.
Laser circumferential scanning photoelectric detection model and analysis of terminal‐sensitive projectile
Authors: Shi Zhijun , Lei Zhiyong 
Published: March 2022

AbstractThe intersection status of terminal‐sensitive projectile and target is uncertain, which leads to the problem that it is difficult to accurately calculate the laser echo power. This paper studies a new calculation method of laser echo power based on laser circumferential scanning detection mechanism and establishes the mathematical model of laser dynamic scanning by the spatial geometric relationship between terminal‐sensitive projectile and ground target. Combining the characteristics of reflected laser echo power of ground target, we derive the laser echo power calculation function with temporal and spatial distribution characteristics. According to the detection requirements, we configure the parameters of the system and carry out quantitative simulation experiments, the results show when the emitting frequency and scanning speed of pulsed laser were matched, the detection probability is the greatest. With the increase of intersection distance, the reflected laser echo power will decrease, which is basically consistent with the simulation results.
Use, and acceptability, of digital health technologies in musculoskeletal physical therapy: A survey of physical therapists and patients
Authors: Merolli M. , Gray K. , Choo D. , Lawford B. J. , Hinman R. S. 
Published: March 2022

AbstractObjectivesDetermine (a) frequency of digital health use to obtain/record clinical information (pre‐COVID‐19); (b) willingness to use digital technologies among physical therapists and patients with musculoskeletal conditions.Methods102 physical therapists, and 103 patients were recruited in Australia. An electronic survey ascertained (a) demographic/clinical characteristics, (b) frequency of methods to obtain and record clinical information; (c) willingness to use digital technologies to support musculoskeletal care.ResultsPhysical therapists mostly used non‐digital methods to obtain subjective (e.g., face‐to‐face questioning, n = 98; 96.1%) and objective information (e.g., visual estimation, n = 95; 93.1%). The top three digital health technologies most frequently used by therapists: photo‐based image capture (n = 19; 18.6%), accessing information logged/tracked by patients into a mobile app (n = 14; 13.7%), and electronic systems to capture subjective information that the patient fills in (n = 13; 12.7%). The top three technologies used by patients: activity trackers (n = 27; 26.2%), logging/tracking health information on mobile apps or websites (n = 12; 11.7%), and entering information on a computer (n = 12; 7.8%). Physical therapists were most willing to use technologies for: receiving diagnostic imaging results (n = 99; 97.1%), scheduling appointments (n = 92; 90.2%) and capturing diagnostic results (n = 92; 90.2%). Patients were most willing to use technologies for receiving notifications about health test results (n = 91; 88.4%), looking up health information (n = 83; 80.6%) and receiving personalised alerts/reminders (n = 80; 77.7%).ConclusionsPhysical therapists and patients infrequently use digital health technologies to support musculoskeletal care, but expressed some willingness to consider using them for select functions.
Improved mechanical, thermal properties and ideal dielectric properties of polyimide composite films by incorporation of boron nitride nanosheets and aramid nanofibers
Authors: Zhang Ting , Huang Yawen , Sun Yi , Tang Pingping , Hu Chengyao 
Published: March 2022

AbstractIn this work, a high‐performance composite film polyimide (PI)/boron nitride nanosheets (BNNS) + aramid nanofibers (ANFs) was prepared by in‐situ polymerization. Modified two‐dimensional (2D) BNNS were prepared by urea‐assisted ball milling to exfoliate and NH2 functionalize hexagonal boron nitride(h‐BN) in one step. One‐dimensional (1D) ANFs prepared by deprotonation method and 2D BNNS were simultaneously incorporated into PI and used as effective reinforcement nanofillers. This novel PI/BNNS + ANFs composite film has excellent thermal stability and mechanical properties. Compared with pure PI, the glass transition temperature (Tg) increased by approximately 18°C, and the coefficient of thermal expansion (CTE) decreased by 11.45%. Remarkably, the tensile strength and elongation at break of PI/BNNS + ANFs‐1 wt% composite film increased by 18.6% and 133.4%, respectively. The improvement of thermal stability and mechanical properties were ascribed to the uniform dispersion of BNNS + ANFs and the interfacial interaction between BNNS + ANFs and PI matrix. Furthermore, the PI/BNNS + ANFs composite films show good dielectric properties and optical transparency. These excellent comprehensive properties of the PI/BNNS + ANFs composite films make it a good candidate for the flexible substrate.
Risk factors for neonatal thrombosis: A retrospective study conducted in a single Canadian intensive care unit
Authors: Bhatia Kulsajan , Solanki Smeet , Paes Bosco , Chan Anthony K.C. , Bhatt Mihir D. 
Published: March 2022

AbstractAmong children, neonates have the highest incidence of thrombosis. We conducted a retrospective review of neonatal thrombosis, in a single intensive care unit (ICU) over 4.5 years. Among 4860 ICU admissions to our center, identified through the Canadian Neonatal Network database, 186 were associated with arterial and venous thrombosis involving 195 thrombotic sites. The neonatal thrombosis incidence was 38 per 1000 neonatal ICU admissions. We assessed patient characteristics and compared the association between risk factors and thrombosis. In the multivariate analysis, central venous catheters, sepsis, and respiratory distress syndrome were significant predictors of neonatal thrombosis.
Mode II interlaminar fracture toughness enhancement of fine z‐pin reinforced carbon fiber composite with low fraction of pins
Authors: Che Zhe , Li Min , Wang Shuo , Wang Shaokai , Gu Yizhuo , Zhang Wei 
Published: March 2022

AbstractThis article aims to improve the shear delamination resistance of composite laminate and minimize implantation damage on fiber orientation by using fine z‐pins. The z‐pins with the diameters as small as 0.1 and 0.2 mm were prepared by using different carbon fibers. The results show that z‐pinning method significantly improves the mode II interlaminar fracture toughness, and the GIIC value becomes larger with the decrease in z‐pin diameter. Compared with the control sample, the precracked GIIC values of (carbon fiber‐reinforced polymer composite) CFRP(0.5CF4X−pin), CFRP(0.2CF4X−pin), and CFRP(0.1CF4X−pin) increase by 67%, 142%, and 176%, respectively. As z‐pin diameter decreases from 0.5 to 0.1 mm, the failure mode changes from z‐pin pullout to shear fracture. The evolution of failure mode greatly enhances the resistance to crack propagation and the final GIIC value. The carbon fiber type of pin(0.5mm) has no obvious influence on the delamination sliding resistance. For pin(0.1mm) and pin(0.2mm), the strong deformation resistance of z‐pin is the dominant factor driving the improvement of the GIIC values though providing high‐shear traction load. In addition, the z‐pins with large shear deformation capacity can also enhance the crack sliding resistance.
Paradigm of sustainable process safety management for industrial revolution 4.0: A circular economy and sustainability perspective
Authors: Toha Md Abu , Akter Rabeya , Uddin Md. Salah 
Published: March 2022

AbstractThe integration of process safety management (PSM) in the transition towards a circular economy (CE) has received increased attention and consideration across a number of disciplines in the recent industrial revolution 4.0. However, questions have been raised about the conventional PSM systems lacking sustainability consideration. The purpose of this study is to introduce an emerging paradigm of sustainable process safety management (SPSM) for the industrial revolution 4.0 from the CE and sustainability point of view. By assessing the US Occupational Safety and Health Administration (OSHA) 1910 and available global PSM frameworks, this study has identified areas of improvement for corporations and presented an SPSM framework from the social, economic, and environmental perspectives in a CE. The proposed framework makes a contribution that connects the sustainability and CE perspective with the PSM and provides a basis for the future sustainable process safety guidelines for policymakers, practitioners, and industries. Additionally, this study proposed a paradigm umbrella that connects to the PSM by focusing on social, economic, and environmental pillars from sustainability that are relevant and applicable for the industrial revolution 4.0. Furthermore, it engraves a trail of imminent research possibilities in adopting an integrated sustainable PSM framework in a CE.
Learning‐based super‐twisting sliding‐mode control for space circumnavigation mission with suboptimal reaching under input constraints
Authors: Dong Hanlin , Yang Xuebo 
Published: March 2022

AbstractThe problem of attitude‐orbit synchronous finite‐time control for the space circumnavigation (SCN) mission with input constraints is investigated in this research article. A novel terminal sliding‐mode (TSM) manifold with nonsingular first derivative is developed to ensure that the sliding‐mode reduced‐order system is practical finite‐time stable. Then, the learning‐based adaptive dynamic programming (ADP) technique is adopted to design a super‐twisting sliding‐mode control scheme, so that the proposed TSM is suboptimal reached. Especially, benefited from the introduction of two nonlinear performance indexes, the proposed sliding‐mode control strategy satisfies the saturation constraint of the propulsion system, and the weight update rate of the actor‐critic (AC) network will not be too large, even if the initial value of the system is too large. Finally, the simulation results show that both attitude and orbital tracking errors in the SCN mission are forced to converge to a small neighborhood containing the origin synchronously under input saturation constraints.
Eutectic Electrolytes Chemistry for Rechargeable Zn Batteries
Authors: Lu Xuejun , Hansen Evan J. , He Guanjie , Liu Jian 
Published: March 2022

AbstractRechargeable zinc batteries (RZBs) have proved to be promising candidates as an alternative to lithium‐ion batteries due to their low cost, inherent safety, and environmentally benign features. While designing cost‐effective electrolyte systems with excellent compatibility with electrode materials, high energy/power density as well as long life‐span challenge their further application as grid‐scale energy storage devices. Eutectic electrolytes as a novel class of electrolytes have been extensively reported and explored taking advantage of their feasible preparation and high tunability. Recently, some perspectives have summarized the development and application of eutectic electrolytes in metal‐based batteries, but their infancy requires further attention and discussion. This review systematically presents the fundamentals and definitions of eutectic electrolytes. Besides, a specific classification of eutectic electrolytes and their recent progress and performance on RZB fields are introduced as well. Significantly, the impacts of various composing eutectic systems are disserted for critical RZB chemistries including attractive features at electrolyte/electrode interfaces and ions/charges transport kinetics. The remaining challenges and proposed perspectives are ultimately induced, which deliver opportunities and offer practical guidance for the novel design of advanced eutectic electrolytes for superior RZB scenarios.
Diagnostic accuracy of sliding sign for detecting pouch of Douglas obliteration and bowel involvement in women with suspected endometriosis: systematic review and meta‐analysis
Authors: Alcázar J. L. , Eguez P. M. , Forcada P. , Ternero E. , Martínez C. , Pascual M. Á. , Guerriero S. 
Published: March 2022

ABSTRACTObjectiveThe aim of this systematic review and meta‐analysis was to evaluate the diagnostic accuracy of the sliding sign on transvaginal ultrasound (TVS) in detecting pouch of Douglas obliteration and bowel involvement in patients with suspected endometriosis, using laparoscopy as the reference standard.MethodsA search for studies evaluating the role of the sliding sign in the assessment of pouch of Douglas obliteration and/or bowel involvement using laparoscopy as the reference standard published from January 2000 to October 2021 was performed in PubMed/MEDLINE, Web of Science, CINAHL, The Cochrane Library,
ClinicalTrials.gov and SCOPUS databases. The Quality Assessment of Diagnostic Accuracy Studies‐2 (QUADAS‐2) was used to evaluate the quality of the studies. Analyses were performed using MIDAS and METANDI commands in STATA.ResultsA total of 334 citations were identified. Eight studies were included in the analysis, resulting in 938 and 963 patients available for analysis of the diagnostic accuracy of the sliding sign for pouch of Douglas obliteration and bowel involvement, respectively. The mean prevalence of pouch of Douglas obliteration was 37% and the mean prevalence of bowel involvement was 23%. The pooled estimated sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of the sliding sign on TVS for detecting pouch of Douglas obliteration were 88% (95% CI, 81–93%), 94% (95% CI, 91–96%), 15.3 (95% CI, 10.2–22.9), 0.12 (95% CI, 0.07–0.21) and 123 (95% CI, 62–244), respectively. The heterogeneity was moderate for sensitivity and low for specificity for detecting pouch of Douglas obliteration. The pooled estimated sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of the sliding sign on TVS for detecting bowel involvement were 81% (95% CI, 64–91%), 95% (95% CI, 91–97%), 16.0 (95% CI, 9.0–28.6), 0.20 (95% CI, 0.10–0.40) and 81 (95% CI, 34–191), respectively. The heterogeneity for the meta‐analysis of diagnostic accuracy for bowel involvement was high.ConclusionThe sliding sign on TVS has good diagnostic performance for predicting pouch of Douglas obliteration and bowel involvement in women with suspected endometriosis. © 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
ISO 39001 Road Traffic Safety Management System, Performance Recording, and Reporting
Authors: Lie Anders , Tingvall Claes 
Published: March 2022

AbstractTraffic safety has shifted from being a solely individual issue to also include responsibilities from those organizations that influences the use and quality of the road transport system. This chapter explores the background of this and presents how ISO 39001 has been introduced as a tool to manage traffic safety in organisations. Further it is setting organizational road traffic safety into context of the 3rd Global Ministerial Conference on Road Safety, the Stockholm declaration and the decision of the United Nations general Assembly. The chapter also discusses how a value chain analysis can help organisations in understanding and tackling their road safety footprint and part of their sustainability reporting.
Innate Immunity
Authors: Dalmo Roy Ambli , Bøgwald Jarl 
Published: March 2022

AbstractResearch on the innate immunity has accelerated over the last decades. The main reason for this has been the discovery of receptors recognizing danger molecules from pathogens. This has been facilitated through genome and transcriptome sequencing of different fish species. Also, endogenous host molecules from sterile physiological insults may also bind to certain receptors and induce immunological processes. The magnitude and quality of adaptive immunity are known to be dependent on the instructions the innate response gives. This chapter gives an overview of selected innate immune organs/tissues, factors, and processes that have been suggested to possess important roles during innate immune response in fish.
Competitive Funding for Institutional Development. The Romanian Experience Between 2016–2020
Authors: Nica Remus , Jitaru Gabriela 
Published: March 2022

AbstractThe Institutional Development Fund (FDI) is a newly introduced component of Romanian institutional funding with the purpose of supporting public higher education institutions (HEIs) in their pursuit of the national strategic objectives for higher education. This policy aims to encourage universities to formulate their own answers (through institutional projects) to current higher education challenges such as equity and access for students, internationalisation, regional development, improving the quality of teaching, supporting the entrepreneurial and practical activities developed for the benefit of students, etc. Given its current form as a simple combination between objective-based funding and competitive funding, and its recent implementation at a national level, we propose an in-depth exploration of the policys results focusing on institutional activities and targeted objectives. To this aim, the paper presents the relevant results obtained by universities in the last five years of FDI implementation, the trends of HEIs institutional development (measured at the university level), as well as the direct and indirect influence these might have over the overall quality of the Romanian higher education system. At the same time, we look to identify new institutional measures in response to the actual needs of universities (in accordance with university autonomy) in order to underline new implementation directions in accordance with national policies and strategies, both in relation to funding and in relation to national goals, as well as to explore the potential of FDI funding for quality enhancement in higher education.