bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of automated feedback laboratory comments promoting good phlebotomy practice on the frequency of ethylenediaminetetraacetic acid (EDTA) contamination of serum samples
Authors: Kalaria Tejas , Ford Clare , Gama Rousseau 
Published: October 2022

Background Ethylenediaminetetraacetic acid (EDTA) contamination of serum samples is common but under-recognized unless EDTA is measured. Incorrect order of draw with closed phlebotomy (vacutainer) does not cause EDTA contamination. EDTA contamination occurs largely or solely during open phlebotomy due to syringe tip or needle-tip contamination when delivering blood into EDTA sample tubes before other sample tubes or direct transfer of blood from EDTA containing tubes to other tubes. Therefore, preference for closed phlebotomy or following the order of tube fill when open phlebotomy is used may reduce EDTA contamination. Methods The laboratory’s comments for EDTA-contaminated serum samples were amended to encourage closed phlebotomy and with open phlebotomy filling of serum tubes before EDTA and fluoride-EDTA tubes. The weekly frequency of EDTA sample contamination, normalized for weekly urea and electrolyte (U&E) requests, was studied 52 weeks before and 43 weeks after amending the comments. Results Median (IQR) frequency of EDTA-contaminated samples per week per 10,000 U&Es decreased by 58% [5.6 (3.1–9.2) versus 2.3 (1.1–4.4); P < 0.001] after the introduction of the new comment. Conclusion Explicit automated laboratory feedback comments promoting closed phlebotomy and order of tube fill with open phlebotomy were associated with a 58% reduction in EDTA-contaminated samples and thus may play a role in improving phlebotomy practise.
Parents’ attitude towards pneumococcal vaccine: an online survey from Jordan
Authors: AL-Iede Montaha , Khanfar Asim N. , Alshrouf Mohammad A. , Azzam Muayad I. , Haddad Tala A. , Khanfar Omar N. , Al-Tarawneh Zaid M. , Aleidi Shereen M. 
Published: October 2022

Objectives In developing countries, the pneumococcal conjugate vaccine (PCV) has not been incorporated into the national immunization schedule, and the vaccination rate is low. This study aimed to examine parental knowledge, attitudes, and barriers to children receiving the PCV in Jordan. Methods This was a questionnaire-based cross-sectional study. The online survey was written in Arabic and consisted of three main sections. The questionnaire was distributed via social media platforms, such as Facebook, Twitter, and WhatsApp. Results In total, 720 responses were analyzed. Only 149 (20.7%) of the parents’ children were vaccinated with the PCV. However, almost half 356 (49.4%) of the respondents were willing to vaccinate their children. Most (563, 78.1%) parents stated that the vaccine would protect their children from pneumococcal disease. More than two thirds (516, 71.6%) of them strongly agreed or agreed that the cost of the PCV is high. Parents who had vaccinated their children had a higher monthly income than parents who had not vaccinated their children. Conclusions This study shows a lack of knowledge regarding pneumococcal infection and the PCV among Jordanian parents. This is the main barrier to vaccinating children. Therefore, improving parental knowledge would increase the rate of vaccination among Jordanian children.
Stability and change in dispositional envy: Longitudinal evidence on envy as a stable trait
Authors: Erz Elina , Rentzsch Katrin 
Published: October 2022

Dispositional envy has been conceptualized as an emotional trait that varies across comparison domains (e.g., attraction, competence, wealth). Despite its prevalence and potentially detrimental effects, little is known about stability and change in dispositional envy across time due to a lack of longitudinal data. The goal of the present research was to close this gap by investigating stability and developmental change in dispositional envy over time. In a preregistered longitudinal study across 6 years, we analyzed data from N = 1229 German participants ( n = 510–634 per wave) with a mean age of 47.0 years at intake ( SD = 12.4, range 18–88). Results from latent factor models revealed that both global and domain-specific dispositional envy were stable across 6 years in terms of their rank order and mean levels, with stability coefficients similar to those of other trait measures reported in literature. Moreover, a substantial amount of variance in global and domain-specific dispositional envy was accounted for by a stable trait factor. Results thus provide evidence for a stable disposition toward the experience of envy both at the global level and within specific envy domains. The present findings have important theoretical and practical implications for the stability and development of dispositional envy in adulthood and advance the understanding of emotional traits in general.
Malignancies among newly diagnosed systemic lupus erythematosus patients and their survival
Authors: Kariniemi Simo , Rantalaiho Vappu , Virta Lauri J , Kautiainen Hannu , Puolakka Kari , Elfving Pia 
Published: October 2022

The objective of this study was to evaluate the incidence of malignancies among newly diagnosed systemic lupus erythematosus (SLE) patients compared to reference individuals. Another aim was to assess the survival of SLE patients with malignancy compared to references with malignancy. Finnish adult (>17 years) newly diagnosed SLE patients were identified by their drug reimbursement decisions made during 1.1.2000–31.12.2014 from the register of the Social Insurance Institution. For each case, three population controls were individually selected by age, sex and place of residence. Overall, 1006 SLE patients (women 84%), with a mean age of 45.5 years (SD 16 years) and 3005 population controls were linked to Finnish Cancer Registry, and the information about incident malignancies was retrieved from the day the special reimbursement decision for SLE medication was accepted (index day, ID) until 31.12.2018 or until death. The patients diagnosed with malignancy were followed up until 31.12.2019 considering survival. During the follow-up, 85 SLE patients (women 78%) and 192 controls (women 78%) had developed one or more malignancy after the ID. The incidence rate ratio for any malignancy was 1.41 (95% CI 1.08–1.85). The most common malignancy in SLE patients was non-Hodgkin lymphoma, with twelve cases. SLE patients with malignancy had a lower adjusted 15-year survival than controls with malignancy, 27.1% versus 52.4%, and the adjusted hazard ratio for death was 1.68 (95% CI 1.17–2.43). Our results confirm that SLE patients have a higher risk for overall malignancy. The results also suggest that SLE patients with malignancy have lower survival than their references with malignancy.
Exploring the concept of non-violent resistance amongst healthcare workers
Authors: Essex Ryan , Aked Hil , Daniels Rebecca , Newton Paul , Weldon Sharon 
Published: October 2022

Background Non-violent resistance which has involved healthcare workers has been instrumental in securing a number of health-related gains and a force in opposing threats to health. Despite this, we know little about healthcare workers who have engaged in acts of non-violent resistance. Research aim Amongst a sample of healthcare workers who had engaged in acts of resistance this study sought to explore their understanding of non-violent resistance and how or whether they felt healthcare workers made a distinct contribution to such action. Research design Cross-sectional survey Participants and research context Healthcare workers (doctors, nurses, academics and others) from the UK and Europe who had engaged in acts of non-violent resistance. Ethical considerations Ethical approval for this study was granted by the University of Greenwich Human Research Ethics Committee (UREC/20.5.6.11). Findings/results Most participants spoke about the nature of non-violent resistance, its oppositional, didactic and symbolic functions and the role of violence or harm. While most people understood non-violent resistance as a public, oppositional and collective act, many identified more subtle everyday acts in the workplace that undermined policy or procedures they saw as harmful. When asked about distinctions in non-violent resistance carried out by healthcare workers, most participants referred to their standing in society, noting that healthcare works were a trusted and authoritative source. Some identified an ethical imperative to act while others identified the risks that came with such action, noting their accountability and responsibility they had to patients. About a quarter of participants felt that such action was no different to others carrying out non-violent resistance or dependent on the issue or nature of the action. Conclusions These findings speak to the complex and multifaceted nature of non-violent resistance. Additionally our findings suggest healthcare workers have a distinct role to play in leading and supporting non-violent actions.
Prediction method and experimental verification of vibration response caused by underground high-speed railways
Authors: Li Hao , Yang Wei-guo , Liu Pei , Wang Meng 
Published: October 2022

Aiming at the problem of vibration caused by underground high-speed railways, this paper proposes a vibration prediction method based on the multi-point transfer ratio in the frequency domain. The transmission information of vibration signals from the tunnel to the surface was obtained by an in situ hammer excitation test, and the acceleration response near the vibration source was calculated via high-precision vehicle-track coupling analysis and a finite element model of the tunnel. Then, the superposition operation was carried out in consideration of the position change of the train, and the surface vibration response caused by the underground high-speed railway was finally predicted. An in situ vibration test was carried out near an underground high-speed railway line and the measured data were compared with the predicted data. The results demonstrate that the predicted and measured time domain peaks were similar, and the main vibration frequencies were both located in the range of 30–70 Hz. Moreover, the 1/3-octave spectra were also very similar, and the root mean square error of acceleration and the Z vibration level error were less than 1.9%. The comparison results show that the proposed method can be used to predict the vibration response caused by the operation of underground high-speed railways with high precision.
Assessing the seam strength of ultrasonically welded polyester and polypropylene spunbond nonwovens
Authors: ÇİNÇİK Emel , İNAN ÜSTÜN Aynur 
Published: October 2022

The durability of the products such as personal protective clothes and facemasks are crucial for human health as these products prevent the spread of disease. This study aims to investigate the seam strength of ultrasonically welded spunbond nonwovens used for personal protective clothes, facemasks, diapers and determine the best welding parameters for optimum seams. For these purposes, polyester and polypropylene spunbond nonwoven fabrics with different areal weights were ultrasonically welded by changing process parameters such as vibration frequency (%-kHz) and welding pressure (bar). The welded samples were evaluated according to the standard test method for seam strength and experimental data obtained from tests were statistically assessed by generating models and regression equations. The best seam strength for polyester nonwovens with different areal weights was achieved with 80% vibration amplitude and 1 bar or 1.5 bar welding pressures. In contrast, ultrasonic welding applied with 0.5 bar welding pressure and 63% or 70% vibration amplitudes resulted in the highest seam strengths for polypropylene nonwovens.
Extremity Pressure in Splints Wrapped With an Elastic Bandage Versus Bias Cut Stockinette: An Experimental Model
Authors: Schoenfeldt Theodore L. , Bowman Christine A. , MacConnell Ashley E. , Fishman Felicity G. 
Published: October 2022

Background: Many variables affect the pressure caused by splinting or casting. The purpose of this study was to compare pressure underlying a splint wrapped with either an elastic bandage or a bias cut stockinette. Methods: Thirty-two plaster volar resting splints were applied to a simulated extremity with a saline bag secured to it. A pressure transducer was connected to the saline bag to monitor changes in pressure once splints were applied, and 15 mL increments of saline were added to the bag to simulate swelling. Each dressing type was tested with normal application and tight application. Results: Normal application splints wrapped with either bias cut stockinette or an elastic bandage demonstrated similar initial splint pressures ( P = .81). With simulated swelling, splints wrapped with bias cut stockinette demonstrated a 15 mmHg (95% confidence interval [CI], 1.5-28.5) higher average pressure than those wrapped with an elastic bandage ( P = .035). Tight application splints with an elastic bandage wrap demonstrated a 46 mmHg (95% CI, 16-77) higher initial splint pressure than those wrapped with bias cut stockinette ( P = .009). Conclusions: Splints wrapped using either an elastic bandage or bias cut stockinette appear to have a similar safety profile, although in cases of excessive swelling, an elastic bandage may provide additional compliance. Tight splint application appears to be more hazardous with the use of an elastic bandage compared with a bias cut stockinette. Further study of the use of elastic bandages and bias cut stockinettes in the clinical setting may be warranted.
Isolated popliteal artery lesion due to giant cell vasculitis post COVID-19 mRNA vaccine and COVID-19 asymptomatic infection
Authors: Gabrielli Roberto , Siani Andrea , Smedile Gianluca , Rizzo Anna Rita , De Vivo Gennaro , Accrocca Federico , Bartoli Stefano 
Published: October 2022

Objective Giant cell arteritis (GCA) is a rare granulomatous vasculitis, affecting medium and large vessels, usually in old patients. The incidence of GCA has been higher during current COVID-19 pandemia and COVID-19 is recognized for its immune dysregulation. Lower limbs involvement is uncommon but can be limb threatening, resulting in limb loss. Method A 43-year-old man presented with a sudden pain in his right calf and foot associated with pallor and hypothermia, and there was objective evidence of ischemia. Symptoms began few days after he received the first dose of a COVID-19 mRNA vaccine and COVID-19 asymptomatic infection 20 days after vaccination. He had no history of any signs of claudication pre-COVID or limb trauma and was very fit. Enhanced computed tomography and magnetic resonance imaging (MRI)suggest diagnosis of popliteal artery cystic adventitial disease. We resected the affected popliteal artery with interposition using a right great saphenous vein graft, through a posterior approach. On the fourth postoperative day, he was discharged. Histopathological examination revealed patchy intramural inflammatory infiltrates composed of lymphocytes and rare multinucleated giant cells at the internal lamina and adventitia consistent with a diagnosis of GCA. Conclusion and Result Our case represents the first reported case of isolated popliteal GCA following vaccination with a COVID-19 mRNA vaccine and COVID-19 infection. We propose that the upregulated immune response to the vaccine acted as a trigger for GCA in this patient with predisposing risk factors and recurrent and repetitive microtrauma in popliteal fossa (the patient is a professional runner). Our case suggests the need for further studies about real world incidence of GCA associated vaccination and COVID-19 infection. Currently, data is limited regarding this relationship. We continue to encourage COVID-19 vaccination, even in elderly patients because the benefits of vaccination far outweigh any theoretical risk of immune dysregulation following administration.
Efficacy and safety of bisphosphonates on childhood osteoporosis secondary to chronic illness or its treatment: a meta-analysis
Authors: Zhao Huawei , Ding Yunfei , Yang Jufei , Luo Yijun , Xu Zhenghao , Miao Jing 
Published: October 2022

Background: Bisphosphonates are a type of medication that prevents the loss of bone density. Secondary childhood osteoporosis reduces bone strength and results in an increased risk of fragility fracture. This meta-analysis aims to explore the efficacy and safety of bisphosphonates on secondary childhood osteoporosis. Methods: We performed a systematic search of PubMed, Cochrane library, and Web of Science databases up to 31 July 2022 to screen for random clinical trials (RCTs) on bisphosphonate treatment for childhood secondary osteoporosis. Data from selected studies, mainly changes in lumbar spine (LS) bone mineral density (BMD), changes in LS BMD Z-scores, fracture events, and adverse events (AEs), were extracted and analyzed. Results: Nine RCTs ( n = 429 in total) were included in our meta-analysis. The meta-analysis indicated that bisphosphonates improved the changes in LS BMD [mean difference (MD) = 0.04, 95% confidence intervals (CIs) = 0.01–0.07, p < 0.01] and LS BMD Z-scores [MD = 0.52, 95% CI = 0.23–0.81, p < 0.01]. Use of bisphosphonates did not increase the risk of AEs [odds ratio (OR) = 1.61, 95% CI = 0.87–2.99, p = 0.13]. Subgroup analysis showed that routes of administration, but not causes of secondary osteoporosis, might influence the efficacy of bisphosphonates. IV bisphosphonates close to significantly improved the incidence of fracture (OR = 0.34, 95% CI: 0.11–1.08, p = 0.07). Conclusions: The use of bisphosphonates improves LS BMD without increasing AE rates, which supports the clinical use of bisphosphonates in secondary childhood osteoporosis. Further large RCTs are still warranted, especially for their long-term effects on fracture rates.
Artificial intelligence healthcare service resources adoption by medical institutions based on TOE framework
Authors: Yang Jinxin , Luo Biao , Zhao Chen , Zhang Hongliang 
Published: October 2022

ObjectivesThis study used the Technology-Organization-Environment (TOE) framework to identify the factors involved in the decisions made by integrated medical and healthcare organizations to adopt artificial intelligence (AI) elderly care service resources.MethodThis study identified the Decision-making Trial and Evaluation Laboratory-Interpretive Structural Modeling (DEMATEL-ISM) method was used to construct a multilayer recursive structural model and to analyze the interrelationships between the levels. A MICMAC quadrant diagram was used for a cluster analysis.ResultsThe ISM recursive structural model was divided into a total of seven layers. The bottom layer contained the four factors of High risk of data leakage (T1), Lack of awareness of the value and benefits of AI healthcare technology (T5), Lack of management leadership support (O1), and Government policies (E1). Having a low dependency but high driving force, these factors are the root causes of adoption by healthcare organizations. The topmost layer contained the most direct factors, which had a high dependency but the low driving force, influencing adoption: Competitive pressures (E2), Lack of patient trust (E5), and Lack of excellent partnerships (E7). Healthcare organizations are more concerned with technology and their environments when deciding to adopt intelligent healthcare resources.ConclusionThe combination of the three methods of DEMATEL-ISM-MICMAC construction models provides new ideas for smart healthcare services for hospitals. The DEMATEL method favors the construction dimension of the micro-model, while the ISM method favors the construction dimension of the macro-model. Combining these two methods may reduce the loss of information within the system, simplify the matrix calculation workload, and improve the efficiency of operations while decomposing the complex problems into several sub-problems in a more comprehensive and detailed way. Conducting cluster analysis of the adoption determinants utilizing MICMAC quadrant diagrams may provide strong methodological guidance and decision-making recommendations for government departments, senior decision-makers in healthcare organizations, and policy-makers in associations in the senior care industry.
Short-term exchange programs in Korean Universities: International student mobility stratified by university mission
Authors: Song Inyoung , Kim Yangson 
Published: October 2022

The purpose of this study was to explore the internationalization of higher education institutions by analyzing partnerships of short-term exchange programs among universities in Korea and abroad. Based on data from 3 years (2008, 2013, and 2017), we used descriptive statistics to analyze the inbound and outbound statuses of overseas universities that have established credit exchange agreements with Korean universities. The analysis showed that the major components of short-term mobility in Korean universities are changing, and that credit exchanges among universities differ depending on the universities’ missions. The results suggest that the stratification of universities can affect the extent and quality of the international experiences to which students have access. Using university-level data, we proved that international exchange patterns differ according to the characteristics of universities.
Eradication of early MRSA infection in cystic fibrosis: a novel study design for the STAR-ter trial
Authors: Cunningham Fiona , Caldwell Ellen , Mayer-Hamblett Nicole , Goss Christopher H. , Muhlebach Marianne S. 
Published: October 2022

IntroductionEarly eradication of methicillin-resistantStaphylococcus aureus(MRSA) in cystic fibrosis is desirable. Prospective studies are challenging owing to the feasibility of recruiting patients with a rare event in an orphan disease. Our prior randomised study (Staph AureusResistance-Treat Or Observe (STAR-too)) showed improved clearance and outcomes with aggressive therapy compared to no treatment. We present a novel trial design to guide treatment for eradicating incident infection with a focus on feasibility.MethodsSubjects with cystic fibrosis with incident MRSA infection were enrolled into theStaph AureusResistance-Treat Early And Repeat (STAR-ter) protocol and treated with a combination of an oral antibiotic and topical (nare and throat) decolonisation. The primary outcome was MRSA-negative respiratory culture at Day 28,i.e.14 days after completion of oral antibiotics. What was novel about this study design was that the control/comparator group was the untreated group of the STAR-too trial. This design was developed because having a “no treatment” group would be unethical given prior findings and a superiority design would delay the time to results based on small numbers of eligible subjects. Both studies used the same inclusion and exclusion criteria and drew subjects from the same geographic regions. The main difference between the studies was the use of a single oral antibiotic, trimethoprim-sulfamethoxazole, rather than the combination with oral rifampin used in STAR-too.DiscussionAn innovative approach to address a clinical question for a rare event in an orphan disease, cystic fibrosis, is presented to enhance current clinical evidence to guide cystic fibrosis care in relation to new MRSA infection.