bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subtractive genomic analysis for computational identification of putative immunogenic targets against clinical Enterobacter cloacae complex
Authors: Bolourchi Negin , Fereshteh Sepideh , Noori Goodarzi Narjes , Badmasti Farzad 
Published: October 2022

BackgroundEnterobacteris a major nosocomial genus ofEnterobacteriaceaeresponsible for a variety of nosocomial infections, particularly in prolonged hospitalized patients in the intensive care units. Since current antibiotics have failed treating colistin- and carbapenem-resistantEnterobacteriaceae, efforts are underway to find suitable alternative strategies. Therefore, this study conducted a reverse vaccinology (RV) to identify novel and putative immunogenic targets using core proteome of 20 different sequence types (STs) of clinicalEnterobacterspp. Moreover, we introduced a structural-based approach for exploration of potential vaccine candidates against theEnterobacteriaceaefamily using their conserved domain analysis.ResultsA number of 2616 core coding sequences (CDSs) were retrieved from 20 clinical strains ofEnterobacterspp. with a similarity of ≥ 50%. Nine proteins with a score of ≥ 20 considered as the shortlisted proteins based on the quartile scoring method, including three TonB-dependent receptors, WP_008500981.1, WP_058690971.1 and WP_058679571.1; one YjbH domain-containing protein, WP_110108068.1; three flagellar proteins, WP_088207510.1, WP_033145204.1 and WP_058679632.1; one spore-coat U domain-containing protein, WP_039266612.1; and one DD-metalloendopeptidase family protein, WP_025912449.1. In this study, proteins WP_058690971.1 and WP_110108068.1 were detected as the top candidates with regard to immune stimulation and interactions with TLRs. However, their efficacy is remaining to be evaluated experimentally.ConclusionsOur investigation introduced common ferrichrome porins with high sequence similarity as potential vaccine candidates against theEnterobacteriaceaefamily. These proteins belong to the iron acquisition system and possess all criteria of suitable vaccine targets. Therefore, they need to be specifically paid attention for vaccine development against clinically important members ofEnterobacteriaceaefamily.
Impact of early life shocks on educational pursuits–Does a fade out co-exist with persistence?
Authors: Dhamija Gaurav , Sen Gitanjali 
Published: October 2022

Background
Changes in climatic conditions have increased the variability in rainfall patterns worldwide. A negative rainfall shock faced by children in the initial 1000 days of life and the resulting malnutrition can harm the likelihood of children’s survival, overall growth, development of the brain, motor skills, and cognitive abilities, leading to poor performance in education and labor market. While the existing findings about the long-run outcomes are mixed, it is essential to understand the nuances in such an estimation.

Methods
Using the exogenous variation in rainfall in India, we estimate the impact of adverse shocks at birth on the cognitive abilities of children at ages 5, 8, 12, and 15, on educational attainments, and the likelihood of studying STEM at higher secondary school.

Results
The Young Lives Survey data from Andhra Pradesh, India, presents evidence of the negative impact of rainfall shocks at birth on cognitive abilities from age 5 to 8, attenuating at age 12. Using nationally representative data, while we investigate the impact of adverse rainfall shocks at birth on academic performance measured by the high school grades and STEM choice at higher secondary school, we do not find a persistent impact.

Conclusion
We unfold the impact of rainfall shocks on a chain of outcomes connected to long-run educational pursuits, as it helps to identify the most crucial stage for policymaking. Since STEM subjects are strongly associated with the labor market, connecting the association with early life shocks seems to be an essential addition to the literature. While we find evidence of reduced cognitive abilities in the early years, those do not seem to persist in the long run. The potential sample selection or attrition biases and the estimates of those biases can explain the nuances of estimating the long-run impact of adverse shocks at birth.
Incidence and factors associated with being lost to follow-up among people living with HIV and receiving antiretroviral therapy in Nyarugenge the central business district of Kigali city, Rwanda
Authors: Ntabanganyimana Daniel , Rugema Lawrence , Omolo Jared , Nsekuye Olivier , Malamba Samuel Sewava 
Published: October 2022

Background
Lost to follow-up (LTFUP) continues to threaten the sustainability of antiretroviral therapy (ART) benefits and success of ART programs. We determined the incidence and predictors of LTFUP among people living with HIV (PLHIV) on ART in Nyarugenge the Central Business District of Kigali city.

Methods
A cohort of PLHIV who initiated ART in 2018 was retrospectively studied for 24 months. Using health facility records, a person who had no record of contact with the health facility for at least three consecutive months was considered LTFUP. LTFUP incidence rates were computed, and the Fine-Gray’s competing risk regression models were used to determine factors associated with time to first LTFUP. Generalized estimating equations (GEEs) were used to analyze repeated measurement outcomes of LTFUP and predictors of LTFUP.

Results
Of 950 participants, 581 (61.2%) were females and 866 (91.2%) were 15 to 49 years old. From 1,586.1 person years of observation (pyo), 148 participants got LTFUP for 451 times. The incidence rate to first event was 9.4 per 100 pyo (95%CI:7.9–10.9) and 31.8 per 100 pyo (95%CI:29.0–34.4) to multiple events. WHO stage, marital status, employment status and person to contact when PLHIV is not reachable were associated with time to first LTFUP event. However, an average participant with a contact person who was not a Community Health Worker (CHW) or a peer educator had higher incidence of LTUP (aIRR = 2.69, 95%CI: 1.43–5.06), an average single patients had higher incidence of LTFUP (aIRR = 1.74, 95%CI: 1.28–2.34) compared to married/co-habiting, and an average self-employed had higher incidence of LTFUP (aIRR = 1.51, 95%CI: 1.14–2.01) compared to participants employed by others. Furthermore, an average PLHIV living out-of-the health facility catchment area had higher incidence of LTFUP (aIRR = 1.55, 95%CI: 1.19–2.01) compared to an average PLHIV living in the health facility catchment area whereas, an average children initiated on first line had lower incidence of LTUP (aIRR = 0.43, 95%CI: 0.21–0.86) compared to adults.

Conclusion
Using CHW and peer educators as contact persons can help to reduce LTFUP while, targeted sensitization and service delivery are needed for single, self-employed and, patients living out of the health facility catchment area.
Die zweite Generation des Kopenhagener Kreises?
Authors: Grage Joachim 
Published: October 2022

Zusammenfassung
Friedrich Leopold Graf zu Stolberg (1750-1819) grew up in Copenhagen when the circle of literati and scholars around Johann Hartwig Bernstorff was effective there. Klopstock was a family friend and later a mentor to the young count, and Stolberg was also well acquainted with other members of the Copenhagen Circle. He wrote his first poems as a teenager, in 1772 he became a member in the Göttinger Hainbund, and he also had close contact with representatives of the Sturm und Drang. The essay asks about the connection between the Copenhagen Circle and Stolberg’s early work (until about 1780). It focuses on the themes of freedom, fatherland and nature. Can Stolberg’s writing be understood as a result or further development of the cultural effectiveness of the Copenhagen Circle – or as a reaction to it?
Engagement im Rahmen der Flüchtlingsthematik
Authors: Ahrens Petra-Angela 
Published: October 2022

Zusammenfassung
Vor dem Hintergrund der Debatten um eine Bedrohung des gesellschaftlichen Zusammenhalts in Folge der Fluchtmigration nach Deutschland seit 2015 geht der Beitrag anhand einer quantitativen Studie aus dem Jahr 2019 den Orientierungen der Engagierten nach, die sich in diesem Feld offenbar polarisiert gegenüberstehen: Auf der einen Seite die zumeist in der Flüchtlingshilfe Tätigen, auf der anderen die überwiegend politisch Aktiven, die sich für eine Begrenzung der Aufnahme von Geflüchteten einsetzen. Ein Schwerpunkt liegt im Vergleich von Werthaltungen, Engagementmotiven und politischen Orientierungen. Anhand einer mehrdimensionalen Konzeption zur Messung der Stärke des gesellschaftlichen Zusammenhalts erweist sich, dass der aktive Einsatz für eine Aufnahmebegrenzung mit einem Vertrauensdefizit einhergeht, das sowohl ein Movens für dieses Engagement darstellt als auch dem gesellschaftlichen Zusammenhalt entgegensteht.
International Lending of Last Resort in Historical and Theoretical Perspectives: Introduction
Authors: Trautwein Hans-Michael 
Published: October 2022

Abstract
This paper provides an introduction to the special issue on international lending of last resort. Starting from debates about rescue operations and unconventional policies of major central banks in the contexts of the Global Financial Crisis and the European Debt Crisis, it draws attention to recurring controversies about trade-offs between averting critical contagion in financial markets and avoiding moral hazard. The need for international lending of last resort in strongly interconnected financial systems is more than ever evident, but there is no clear consensus on how to manage it. The contributions to this special issue put relevant issues in historical and theoretical perspectives.
Central Bank Cooperation and Lending of Last Resort in the Scandinavian Monetary Union
Authors: Ögren Anders , Trautwein Hans-Michael 
Published: October 2022

Abstract
The functioning of multi-nation monetary unions with several central banks is conditioned by many factors and considerations, such as the capacity to deal with crises, the political will and operational skill to foster financial integration and to develop a mix of rules and discretion in the cooperation between the central banks. The Scandinavian monetary union (SMU) between 1873 and 1931 is a case in point for illustrating the importance of these factors and considerations. We examine the policies implemented in the Scandinavian countries to deal with asymmetries of payments flows and with financial crises at three levels: in an account of major crises that required lending of last resort, in a study of the clearing and settlement mechanism established in the union, and in a survey of contemporary economists’ views on lending of last resort and cooperation in the SMU.
“Where’s my swap line?”
Authors: Mehrling Perry 
Published: October 2022

Abstract
The past two decades have seen the construction of a tiered system of international liquidity provision, the first tier including those whose credit is sufficient for a swap line with the Fed, the second tier including those who can offer acceptable collateral to the Fed, and the third tier including everyone else. It is a global dollar system, with the Fed operating de facto as the global central bank providing international lender of last resort support to the system. It is a system created not so much by conscious design, but rather as a pragmatic response to crisis, bit by bit over time.
Untraditional solution for enhancing the performance of U-20 % Zr metallic alloy as an ATF using liquid metal bonded gap
Authors: Mohsen Mohamed Y. M. , Abdel-Rahman Mohamed A. E. , Galahom A. Abdelghafar 
Published: October 2022

Abstract
This study looks for innovative methods to improve the overall performance of the U-20% Zr metallic fuel. The first solution is to swap out the helium gap for a ternary liquid metal bonded gap while the second involves minimizing the helium gap’s thickness to 0.04 mm in order to minimize its thermal resistance. The proposed solutions have been subjected to neutronic, thermal-hydraulic, and solid structure investigations, and their performance has been contrasted with that of a typical U-20% Zr metallic alloy with a 0.08 mm He-gap. According to neutronic analysis, the investigated fuel materials have almost identical neutronic performance. After using the LM bonded gap, both thermal-hydraulic and solid structure performance improved significantly. The performance of the U-20% Zr with 0.04 mm He-gap was moderate and unattractive to be used since it was deduced that its drawbacks outweighed its benefits.
Simple naturally occurring β-carboline alkaloids – role in sustainable theranostics
Authors: Bhattacharya Piyali , De Swati 
Published: October 2022

Abstract
This review is a brief treatise on some simple β-carboline alkaloids that are abundantly available in plants, animals and foodstuff. These alkaloids are well known for their pharmacological action as well as their allelopathic behaviour. The focus of this review is on sustainable use of naturally occurring compounds in safeguarding human health and protecting our environment at large i.e. the prospective applications of these molecules for Sustainable Theranostics
. The review commences with an initial introduction to the β-carboline alkaloids, followed by an outlay of their geographical distribution and natural abundance, then the basic structure and building units of the simplest β-carboline alkaloids have been mentioned. This is followed by a discussion on the important methods of extraction from natural sources both plants and animals. Then the foundation for the use of these alkaloids in Sustainable Theranostics
has been built by discussing their interesting photophysics, interactions with important biological molecules and an extensive survey of their therapeutic potential and allelopathic behaviour. Finally the review ends with a silver lining mentioning the future prospective applications of these alkaloids with special relevance to sustainability issues.
Effects of Age and Sex on Aerobic Fitness, Sprint Performance, and Change of Direction Speed in High School Athletes
Authors: Hackett Daniel A. , He Wu , Fleeton Jennifer R.M. , Orr Rhonda , Sanders Ross H. 
Published: October 2022

Abstract
Hackett, DA, He, W, Fleeton, JRM, Orr, R, and Sanders, RH. Effects of age and sex on aerobic fitness, sprint performance, and change of direction speed in high school athletes. J Strength Cond Res 37(5): 325–331, 2023—The purpose of this study was to examine the effects of sex and age on aerobic fitness, sprinting performance, and change of direction speed (CODS) in high school athletes, with consideration for maturity. This cross-sectional study involved 2,132 adolescents (1,415 male and 717 female athletes) aged 12.0–15.9 years. Assessment of aerobic fitness using the 20-m multistage fitness test (20MSFT) and 20-m sprint and CODS using the 505 test was performed. For the analysis of data, subjects were separated into 4 age groups: U/13 years, U/14 years, U/15 years, and U/16 years. Estimated age at peak height velocity was a covariate in the data analysis to control for maturity status. Compared with female athletes, male athletes had superior performances at all age groups in 10-m sprint (p < 0.001, effect size [ES] = >−0.44), 20-m sprint (p < 0.001, ES = >−0.55), and 505 test (p < 0.001, ES = >−0.41). Female athletes performed better than male athletes in 20MSFT at U/13 (p < 0.01, ES = −0.22); however, male athletes had better performances at U/15 (p < 0.01, ES = 0.27) and U/16 (p < 0.001, ES = 0.67). At each consecutive age group, male athletes improve their performances in 20MSFT and sprints and at U/14 and U/16 in the 505 test (p < 0.001, ES > −0.37). Female athletes showed no improvement in the 20MSFT and 505 test between U/13-U/16 but showed improved sprint performance at U/15 compared with U/13 and at U/16 compared with U/14 (p < 0.05). This study shows that adolescent male athletes perform consistently better than female athletes in running-related field-based tests and display continuous improvements across age groups.
Pengaruh Metode Pembelajaran Role Playing dan Picture and Picture terhadap Keterampilan Menulis Siswa
Authors: Puspasari Shandra , Ridwanudin Dindin 
Published: October 2022

Penelitian ini bertujuan untuk untuk mengetahui pengaruh Metode Pembelajaran Role Playing dan Picture and Picture terhadap Keterampilan Menulis Siswa MI/SD Kelas IV SDN Pesanggrahan 02 materi Mahluk Hidup dan Lingkungannya, Tahun Ajaran 2019/2020. Metode yang digunakan dalam penelitian ini adalah metode quasi eksperimen dengan desain penelitian Two Group Pretest Postest Design. Subjek penelitian ini adalah 48 orang siswa yang terdiri dari 24 orang siswa untuk kelas eksperimen dan 24 siswa untuk kelas kontrol. Teknik pengumpulan data menggunakan tes, tes yang digunakan berupa lembar pengayaan berupa soal essai. Hasil penelitian menunjukkan, nilai rata-rata kelas post test kemampuan berpikir kelas eksperimen yaitu 85,58 dan rata-rata post test kelas kontrol 75,21. Hasil penelitian berdasarkan hasil post test kemampuan menulis siswa terdapat perbedaan signifikan antara kelas eksperimen dan kelas kontrol, sehingga dapat disimpulkan bahwa dengan menggunakan Metode Pembelajaran Role Playing dan Picture and Picture terdapat pengaruh pada Keterampilan Menulis Siswa MI/SD Kelas IV SDN Pesanggrahan 02
Increasing Frequency of Affirmed Name and Pronoun Documentation in a Pediatric Emergency Department
Authors: Sequeira Gina M. , Kidd Kacie M. , Thornburgh Caitlin , Ley Alexandra , Sciulli Darci , Clapp Megan , Pitetti Raymond , Matheo Loreta , Womeldorff Heather , Christakis Dimitri A. , Zuckerbraun Noel S. 
Published: October 2022

BACKGROUND AND OBJECTIVES
In a previous study of 204 transgender and gender diverse youth in our region, 44% reported being made to feel uncomfortable in the emergency department (ED) because of their gender identity. The objective of our study was to conduct a 2 year quality improvement project to increase affirmed name and pronoun documentation in the pediatric ED.

METHODS
Using process mapping, we identified 5 key drivers and change ideas. The key driver diagram was updated as interventions were implemented over 3 Plan–Do–Study–Act cycles. Our primary outcome, the percentage of ED visits per month with pronouns documented, was plotted on a run chart with the goal of seeing a 50% increase in form completion from a baseline median of ∼14% over the 2 year study period.

RESULTS
The frequency of pronoun documentation increased from a baseline median of 13.8% to a median of 47.8%. The most significant increase in pronoun documentation occurred in Plan–Do–Study–Act cycle 3, immediately after ED-wide dissemination of a near-miss case and subsequent call for improvement by ED leadership. Roughly 1.7% of all encounters during the study period involved patients whose pronouns were discordant from the sex listed in their electronic health record.

CONCLUSIONS
This quality-improvement project increased the frequency of pronoun documentation in the ED. This has the potential to improve the quality of care provided to transgender and gender diverse youth in the ED setting and identify patients who may benefit from receiving a referral to a pediatric gender clinic for additional support.
El manuscrito "Aldecoa": un testimonio desconocido y completo del "Sueño de la muerte"
Authors: Rodríguez Cáceres Milagros 
Published: October 2022

En este artículo se difunde la feliz noticia del hallazgo de un nuevo manuscrito del Sueño de la muerte de Quevedo, con la particularidad de que es el único de los conservados (si exceptuamos otro hasta ahora desconocido del que daremos cuenta próximamente) en que la pieza aparece completa. La letra es del siglo XVII. Lleva por título Sueño de la Muerte y Visita del Marqués de Villena en la redoma.
Tras ofrecer una detallada descripción del documento, se intenta establecer la filiación del texto, analizando las coincidencias y discrepancias con los restantes testimonios conocidos. Llegamos así a la conclusión de que es fruto de una cadena de contaminaciones. Entronca, en un momento u otro, con diversas fuentes manuscritas e impresas, que debieron de mezclarse en copias que no se conservan. Al final del estudio, se registran todas las variantes que ofrece respecto a la edición crítica de Crosby.
El erotismo en la poesía amorosa de Quevedo: los objetos del deseo
Authors: Gallego Zarzosa Alicia 
Published: October 2022

El propósito de este artículo es rastrear el significado y contenido eróticos de los objetos que rodean a la figura femenina en los poemas amorosos de Quevedo, para finalmente obtener algunas conclusiones y reflexiones sobre el erotismo en la poesía de Quevedo referida a la mujer, más refinado y voluptuoso que las (en ocasiones un tanto burdas) alusiones eróticas de su poesía satírica.
Los que podemos llamar «objetos del deseo» cobran una importancia más allá de lo ornamental: nos acercan a la amada en el mundo familiar femenino en el que ésta se mueve y revelan su potencial como términos de agudas metáforas eróticas, implicando al lector en el ambiente de la mujer y compartiendo con él la belleza oculta del mundo femenino.
Pacem In Terris. Mención / Mention
Authors: García-Pellicer Pablo , Martínez Idoia , Martínez Javier , Martínez Sara , Montreal Luis-Miguel , Prieto María-José 
Published: October 2022

La Iglesia ocupa el lugar central del proyecto, tanto en su sentido físico como en el espiritual, y su presencia se destaca por encima de los muros que estructuran la intervención.
El campus se incorpora al proyecto introduciéndose entre los muros y creando recorridos libres a través de un único espacio caracterizado de distintos modos (en ocasiones es introvertido, en otra se abre hacia el campus), unas veces a mirar hacia el norte, otras mira hacia el sur...)
A Simple MRI-Based Visual Guide To Differentiate Alzheimer’s Disease From Mild Cognitive İmpairment
Authors: ÇANKAYA Şeyda 
Published: October 2022

Objective: To distinguish between mild cognitive impairment (MCI) and Alzheimer’s disease (AD) by visual assessment of the length of the hippocampus in magnetic resonance imaging (MRI).
Method: Consecutive patients diagnosed with MCI and AD were searched on the system retrospectively. MRI was rated for hippocampal atrophy defining with and without loss of hippocampal length. Patients with loss of hippocampal height were classified as having AD by the clinical investigator, and the diagnosis of the patients was checked on the system.
Results: A total of 56 memory clinic patients with AD (n=14) and MCI (n=42) were included in the study. AD patients had significantly more hippocampal atrophy than MCI patients (𝜒2=6.222, df=0.13, 𝑝=0.013).
Conclusion: There is a complex issue in the differential diagnosis between MCI and AD. A simple glace to the MRI may give a brief opinion to the physician in the clinic routine.
THE INFLUENCE OF INTERCOMPANY RELATIONS ON THE INNOVATION PERFORMANCE: АN EMPIRICAL STUDY OF RUSSIAN INDUSTRIAL COMPANIES
Authors: Trachuk A. V. , Linder N. V. 
Published: October 2022

The interaction of companies in the innovation process is the basis for successful innovative development, as it allows industrial companies to reduce the time to market new products, cut production costs, increase operating profit. At the same time, an optimal choice of key partners is necessary to succeed in achieving the overall goals of innovative development. Currently, there are no studies that would answer the questions: is the interaction of companies implementing different models of innovative behavior effective? Will innovative companies earn a positive return from interaction with imitation companies? What models of interaction can be optimal between innovative companies and imitation companies?The purpose of this study is to determine how the structure of the partnership, membership and characteristics influence the innovative performance of industrial companies. The study was conducted on a sample of 270 large Russian industrial companies. An econometric model based on the Cobb - Douglas production function was used for the analysis.