bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing Digital Business Organisations: An interconnected Literature Review
Authors: Nichifor Eliza , Țierean Ovidiu Mircea , Vuță Daniela Roxana , Zamfirache Alexandra , Chițu Ioana Bianca , Foriș Tiberiu , Brătucu Gabriel 
Published: May 2022

Abstract
Internet economy has revolutionized people's lives, and this has led to a major paradigm shift in society, especially in the post-pandemic context. Knowledge areas such as cybersecurity, e-commerce, economic intelligence management, and digital resilience have not been reviewed as a unit so far. Thus, the study aims to demonstrate and promote the interconnection of these four research areas. The authors performed an analysis of 18,684 papers from Web of Sciences that generated four visualized networks, analysed with the metrics mean silhouette, modularity, betweenness centrality, and citation bursts. The mapping process generated results that show that human factor represents the central junction, and the adoption of the e-commerce and mobile commerce are two challenging research lines in the global economic resilience. Moreover, technological change and intelligent operations enabled with big data, artificial intelligence, machine learning, and even blockchain technology can strengthen the resilience in the post-pandemic context.
Characteristics and risk factors associated with mortality during the first cycle of prone secondary to ARDS due to SARS-CoV-2 pneumonia.
Authors: Gonzalez Cecilia , Musso Gabriel , Louzan Jesica Rodriguez , Dominguez Juan Manuel , Gomez Celeste , Appendino Gabriel , Abarca Analia , Clemente Lucio , Baravalle Ezequiel , Latasa Diana , Lopipi Antonella , Rango Juliana , Stezer Giuliana , Calabrono Santiago , Finos Luisina , Berloni Luciano , Pizzo Estefania , Gerber Fernando , Cavagnari Melina , Suarez Gustavo , Alessio Gustavo , Montagner Florencia , Abbondanzieri Ornella , Idbetan Lucas , Bracconi Faustino , Ramos Agnel , Manago Martin , Lovesio Carlos , Estenssoro Elisa 
Published: May 2022

Abstract
IntroductionEarly identification of patients with failure to prone position allows other treatments which could decrease mortality. The objective of our study was: describe the characteristics, behavior of oxygenation and pulmonary mechanics in mechanically ventilated patients with ARDS due to SARS-CoV-2 treated with prone position. Secondary objectives were identify independent determinants of mortality; particularly, number of prone cycles associated with mortality.MethodsIt was a prospective study. All patients with <150 mmHg PaO2/FiO2 ratio and prone position were included and classified according to the PaO2/FiO2 behavior after the first prone cycle: 1) No increase, 2) Increase < 25%, 3) 25-50% increase 4) Increase >50%. The number of prone cycles was also recorded. Baseline characteristics, severity scores, respiratory mechanics and PaO2/FiO2 ratio behavior were compared between survivors and non-survivors.Statistical analysis was performed by Mann Whitney's, Chi² Test and Wilcoxon range tests. Independent factors associated with in-hospital mortality were identified by means of Cox regression.Results273 were treated with prone position over 18 months. The baseline PaO2/FiO2 was 116 [97-135] mmHg (115 [94-136] in survivors versus 117 [98-134] in non-survivors; p=0.50). After prone position, 22 patients (8%) had the same value in PaO2/FiO2 ratio; 46 patients (16%) showed an increase equal less or equal 25%; in 55 patients (21%) there was an increase between 25 and 50% over baseline; and in 150 patients (55%) the rise was greater than 50%. Mortality was 86%, 87%, 72%, 50% respectively. (p<0.001). Having debuted with PaO2/FiO2, ratio < 100 mmHg did not imply that the patient was refractory to the prone position.Of the 273 patients, 127 (46%) required 1 prone cycle, 57 (20%) 2 cycles, 50 (17%) 3 cycles, 17 (6%) had 4 cycles and 19 (7%) 5 or more cycles. Mortality was 55%, 70%, 70%, 82%, and 70% respectively (p<0.001). Factors independently associated with mortality were the percentage of increase in PaO2/FiO2 after 24 hours in prone, age, and the number of prone cycles. ConclusionsOlder patients unable to improve PaO2/FiO2 after 24 hours in prone and who require more than 1 prone cycle, may be candidates for other treatments for refractory hypoxemia.
Assessment of the Correlation between the Levels of Physical Activity and technology usage among Children with Down Syndrome in Riyadh Region
Authors: Alwhabi Reem. M. , Omer Asma B , Khan Ruqaiyah , Albashir Felwa , Alkuait Noura , alhazmi Rawan 
Published: May 2022

Abstract
Background: Children with Down Syndrome (C-DS) have language, cognitive and communication difficulties, apart from consistent physical inactivity that contribute to poor health and higher disability adjusted life years. The purpose of this study was to determine the correlation between use of electronic technology and levels of physical activity in C-DS in Saudi Arabia.Methods: Cross-sectional study conducted with 49 mothers, who had a child (6-12 years in age) with DS, were recruited using purposive sampling, from three DS centers in Riyadh, Saudi Arabia. Children’s Physical Activity Questionnaire and Research Questionnaire on the Impact of Technology on Children were used. Descriptive statistics were used to describe the demographics. Pearson’s correlation, student t-test and Chi-square test were used to find association between technology use, physical activity level and socio-demographic variables.Results: There is no significant correlation between physical activity and use of technology by C-DS. However, there is a negative correlation between high level of physical activity and technology use (R=-0.037). No significant correlation between the mother’s characteristics and technology use was found; but, for the education level of mothers and technology use by C-DS, there is a significant positive correlation (p= 0.05). However, there is no association between the physical activity level and gender of the child with DS.Conclusion: The presented study found that no significant relationship exists between the use of electronic gadgets and the level of physical activity in C-DS.
Powder-Activated Coke Prepared from Coal Fast Pyrolysis: Fractal Characteristics and SO2 Adsorption
Authors: Feng Tai , Kong Qiwen , Xue Jiangwei , Li Longzhi , Liu Peiyi , Li Shanchuan , Zhang Zhen 
Published: May 2022

Abstract
Powder activated coke is a porous material with fractal characteristics. The fractal analysis of powder activated coke prepared under different atmospheres were carried out to understand its surface irregularity and pore complexity. The Frenkel–Halsey–Hill (FHH) method was used to determined two fractal dimensions D1 and D2, under relative pressures of 0–0.5 and 0.5–1, respectively. The relationship between the preparation conditions and fractal dimension was investigated and the influence of the fractal dimensions on the SO2 adsorption characteristics was also studied. The results indicate that the fractal dimensions were influenced by the concentrations of activation agents with D1 ranging from 2.1838 to 2.8643 and D2 ranging from 2.7485 to 2.9257. An n-shaped curve-based relationship between fractal dimensions and coke yields is observed with a peak values of fractal dimensions appearing around 64% yield. The SO2 adsorption capacity shows a consecutively positive linear correlation with D2, while it illustrates distinctly different linear rates with D1 in intervals of 2–2.6 and 2.6–3, respectively.
Persistent lymphopenia after chemotherapy and/or radiotherapy predicted unfavorable outcome in breast cancer patients - a retrospective cohort study
Authors: Dong Minjun , Zhuo Wenying , Luo Liang , Luo Lixi , Shen Jianguo , Yu Haitao , Lu Yi , Chen Danzhi , Chen Wenjun , Zhao Wenhe , Wang Linbo , Wu Zhongyu 
Published: May 2022

Abstract
Background
Lymphopenia was often observed during follow-up for cancer patients, this study aimed to evaluate the prognostic value of prolonged lymphopenia for breast cancer patients.
Methods
This was a retrospective cohort analysis of 296 patients with clinical stage I-III operable breast cancer, who had received chemotherapy and/or radiotherapy. Absolute lymphocyte count lower than 1.1×10^3/ul was defined as lymphopenia. Lymphopenia around the 6th month after chemo-radiotherapy was defined as cohort L, while normal Absolute lymphocyte count was defined as cohort N. Predictors of lymphopenia were assessed using univariate and multivariate logistic regression analyses. Kaplan–Meier and Cox regression analyses were used to evaluate the relationship between the two cohorts.
Results
The baseline characteristics analysis: comparing to cohort N, cohort L had more Stage III(47.4% vs. 25.5%) and less Stage I cancer(12.3% vs. 20.1%)(p = 0.005), more patients experienced combined chemotherapy regimen(86.0% vs. 69.5%, p = 0.012), more patients experienced radiotherapy(78.9% vs. 64.9%, p = 0.041), and less patients experienced endocrine therapy(54.4% vs. 68.2%, p = 0.049). Multivariate logistic regression analysis revealed two negative independent factors associated with DFS: pTNM staging (stage II vs. I: HR = 5.346, 95% CI: 2.286–12.504, p < 0.001; stage III vs. II: HR = 3.089, 95% CI:1.739–5.487, p < 0.001), and ALC status 6 months after chemo- and/or radiotherapy (HR = 2.445, 95% CI: 1.577–3.788, p < 0.001). Cohort L had significantly shorter DFS (log rank: p < 0.001), as well as significantly shorter OS (log rank: p < 0.001).
Conclusion
Persistent lymphopenia after chemotherapy and/or radiotherapy was an independent predictor for breast cancer relapse and unfavorable survival.
The 22nd chromatography component of Fasciola gigantica excretory- secretory product decreased the proliferation of peripheral blood mononuclear cells from buffalo
Authors: Yuan Xiang-Xiang , Zhai Le-Le , Wei Ke-Long , Chen Ming-Tang , Kong Xin-Ping , Zhang Wei-Yu , Di Wen-Da 
Published: May 2022

Abstract
The 22nd chromatography component of the Fasciola gigantica excretory-secretory product (FgESP), F22, has shown potential diagnostic value, and diagnostic methods based on FgESP have also been established. Thus, exploring its immunomodulatory function and possibility as a molecular vaccine candidate is attractive. In the present study, the effect of F22 on the mitogen-induced proliferation of buffalo peripheral blood mononuclear cells (PBMCs) was studied. PBMCs were incubated with concanavalin A (ConA) and phytohemagglutinin (PHA) at optimal (1 µg/well) or suboptimal (0.25 µg/well) doses coupled with FgESP and F22 at different doses (1–16 µg/well). Then, cell proliferation was determined by microenzyme reaction colorimetry (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) assay). FgESP had a slight effect on the proliferation of buffalo PBMCs stimulated with ConA and PHA, while F22 decreased the proliferation of PBMCs stimulated with ConA and PHA at both optimal and suboptimal doses. Further studies should be performed to investigate the immunomodulatory function of F22.
The diagnostic test accuracy of telemedicine for detection of surgical site infection: a systematic review and meta-analysis
Authors: Lathan Ross , Sidapra Misha , Yiasemidou Marina , Long Judith , Totty Joshua , Smith George , Chetter Ian 
Published: May 2022

Abstract
IntroductionThe Sars-CoV-2 pandemic catalysed integration of telemedicine worldwide. This systematic review assesses it’s accuracy for diagnosis of Surgical Site Infection (SSI). MethodsDatabases were searched for telemedicine and wound infection studies. All types of studies were included, only paired designs were taken to meta-analysis. QUADAS-2 assessed methodological quality. Results1400 titles and abstracts were screened, 61 full text reports were assessed for eligibility and 17 studies were included in meta-analysis, mean age was 47.1±13.3 years. Summary sensitivity and specificity was 87.8% (95% CI, 68.4-96.1) and 96.8% (95% CI 93.5-98.4) respectively. The overall SSI rate was 5.6%. Photograph methods had lower sensitivity and specificity at 63.9% (95% CI 30.4-87.8) and 92.6% (95% CI, 89.9-94.5). ConclusionTelemedicine is highly specific for SSI diagnosis is highly specific, giving rise to great potential for utilisation excluding SSI. Further work is needed to investigate feasibility telemedicine in the elderly population group. Registration and no.: Prospero ID - CRD42021290610
Identification of QTLs and Candidate Loci Associated with Drought-Related Traits of the K/Z RIL Rice Population
Authors: Dwiningsih Yheni , Thomas Julie , Kumar Anuj , Gupta Chirag , Gill Navdeep , Ruiz Charles , Alkahtani Jawaher , Baisakh Niranjan , Pereira Andy 
Published: May 2022

Abstract
Background: Rice is the main staple food for the global population and drought is one of the limited factor in rice production. In this research, progeny of a cross between an adapted U.S. rice cultivars with a tropical japonica and an indica rice genotype, were screened for drought resistant (DR) traits to identify DR loci, that would be useful for breeding U.S. rice cultivars for a water saving agricultural system.Results: A recombinat inbred line (RIL) population, generated from selfed progeny of the cross between the drought resistant tropical japonica U.S. cultivar Kaybonnet and an indica drought sensitive cultivar ZHE733, was chosen for quantitative trait locus (QTLs) analysis of drought-resistance related traits. The DR traits were quantified by measuring different parameters of morphological traits, grain yield components and root architectural traits. K/Z RIL population of 198 lines were screened in the field at Fayetteville (AR), by giving controlled drought stress (DS) and well-watered (WW) treatment at the reproductive stage, consequently for three years and the effects of DS were quantify by measuring morphological traits and grain yield components. The effect of abscisic acid (ABA) sensitivity screen on parents and 198 lines at the V3 stage in culture media was quantified by measuring root architectural traits. QTL analysis was performed with a set of 4133 single nucleotide polymorphism (SNP) markers by using QTL IciMapping software version 4.2.53. A total of 41 QTLs and 184 candidate genes within the DR-QTL regions were identified for drought related traits. The potential candidate genes were validated by RT-qPCR of parental lines. The results of candidate DR genes revealed that the gene expression of 15 candidate DR genes with known annotations, and two candidate DR genes with unknown annotations within the DR-QTL regions were up-regulated in the drought resistant parent (Kaybonnet) compared to the drought sensitive parent (ZHE733) under DS conditions.Conclusions: In this study, we detected 41 QTLs and 184 candidate genes within the DR-QTL regions, and most of the candidate genes were up-regulated in Kaybonnet as the drought resistant parent. The findings of this research provide important information to develop drought-resistant rice varieties with greater productivity under DS conditions.
4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity
Authors: Zhou Fengxu , Huang Ruoyue , Cao Tingting , Liu Jia , Yang Weimin , Li Fei , Li Xian 
Published: May 2022

Abstract
Three new 4-phenylcoumarins, mesuaferlinns A–C (1–3), together with ten known 4-phenylcoumarins, 4–13, were isolated from the branches and leaves of Mesua ferrea Linn. (Clusiaceae). The structure of compounds 1–3 were determined on the basis of spectroscopic methods including extensive analysis of NMR and mass spectroscopic data. Ten 4-phenylcoumarins were tested for their cytochrome P450 family 1 enzymes (CYP 1A1, CYP 1A2, and CYP 1B1) inhibitory effects. Compounds 5 and 10 were found to be the most potent two CYP1B1 inhibitors with inhibitory viabilities values of 56.64% and 47.46%.
TPI1 Contributes to the Development of Aortic Aneurysm by Promoting VSMC Phenotypic Switching and MMP2/9 Secreting
Authors: Chen Liangwan , Zheng Hui , Qiu Zhihuang , Zhang Yuling , Wang Chaoyun , Li Yumei , Zhang Li 
Published: May 2022

Abstract
Background:
Triosephosphate isomerase 1 (TPI1) is a crucial enzyme in glycolysis/gluconeogenesis and has been associated with a variety of diseases. However, there is little information on TPI1 and aortic aneurysms (AA). This study was designed to reveal the association between TPI1 and aortic aneurysms, and the mechanisms underlying TPI1 activity in AAs.
Methods:
Tandem Mass Tag (TMT)-based Liquid chromatography mass spectrometry/mass spectrometry (LC-MS/MS) and the Mann-Whitney test were used to compare variables between AA and normal aortic tissues. Gene ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were analyzed using Fun-Rich software. The expression of the TPI1 protein in human aortic tissues was verified by Western blotting. A mouse AA model was established by infusing Ang-II for 4 weeks, then the expression of TPI1, SM22, α-SMA, OPN and MMP2/9 proteins were evaluated by western blotting. TPI1 overexpression was achieved by transfection of TPI mRNA, and its effect on gene expression was studied by RT-qPCR and western blotting, which included SM22, α-SMA, OPN, and MMP2/9. Ang II-induced expression of TPI1 and phenotypic-related genes in VSMCs.
Results:
TPI1 is closely related to the glycolysis/gluconeogenesis pathway and is higher in AA. Expression of TPI1 was upregulated in AA aortic samples of both human and mouse models, p < 0.05. Vascular smooth muscle cells (VSMCs) transfected with TPI mRNA induced lower mRNA and protein levels of SM22 and α-SMA, and higher levels of OPN, p < 0.05. Furthermore, the expression of MMP2/9 was also increased, P < 0.05. The same results that from the VSMCs were induced by Ang-II.
Conclusions:
Higher expression of TPI1 is associated with AA and contributes to the phenotypic switching of VSMC and increased expression of MMP2/9 observed in AA. TPI1 represents a novel target warranting further research towards improving treatment outcomes in candidates with AA.
A novel chromosomal fragment deletion in the APRR2 repeated locus modulates dark sterm color in Cucurbita pepo
Authors: Zhu Lei , Wang Yong , Zhang Zhenli , Hu Deju , Wang Zanlin , Hu Jianbin , Ma Changsheng , Yang Luming , Sun Shouru , Li Yanman 
Published: May 2022

Abstract
Stem color is an important agronomic trait in zucchini ( Cucurbita pepo , C. pepo ) for robust seedings and high yield. However, the gene controlling this trait has not been characterized. This study identified a single locus accounting for dark green stem color in C. pepo ( CpDsc-1 ). Genetic analysis of this trait in segregation populations derived from two parental lines (line 296 with dark green stem and line 274 with light green stem) revealed that it was controlled by a single dominant gene (dark green vs. light green). Using the bulked segregant analysis method, CpDsc-1 was mapped to a 2.09 Mb interval on chromosome 15. Then this region was further narrowed down to 65.2 kb using linkage analysis in the F 2 population. Sequencing analysis revealed a 14 kb deletion between Cp4.1LG15g03420 and Cp4.1LG15g03360 , encoding a two-component response regulator-like protein (APRR2). The incomplete structures of the two APRR2 genes and the abnormal chloroplasts in line 274 might be the main reason for the light green phenotype. Gene expression pattern analysis showed that only Cp4.1LG15g03420 was upregulated in line 296. The subcellular localization analysis indicated that Cp4.1LG15g03420 was a nuclear gene. Furthermore, a co-dominant marker G4563 (93% accuracy rate) and a co-segregation marker Fra3 were established in 111 diverse germplasms, and both were tightly linked with the color trait. This study provide new insight into the chlorophyll regulation pathway, and these markers would be valuable for marker-assisted selection in zucchini breeding.
Updated taxonomy of Chinese Clavaria subg. Syncoryne (Clavariaceae, Agaricales): description of two new species and one newly recorded species
Authors: Yan Jun , Li Gui-Wu , Liu Wen-Hao , Chen Zuo-Hong , Zhang Ping 
Published: May 2022

Abstract
Species of Clavaria (Clavariaceae, Agaricales) collected from China were studied using morphological and molecular methods. Two species, C. aspersa and C. hupingshanensis, are here described as new to science; the former possesses simple, scattered to gregarious or with pairs slightly fascicled, white basidiomata, whereas the latter has simple, gregarious to caespitose clusters, rose-white to seashell-pink basidiomata. In addition, C. amoenoides is described as a newly recorded species for China; this species is characterized by simple, very pale orange-yellow to picric-yellow basidiomata. A phylogenetic analysis was conducted based on a combined dataset of internal transcribed spacer, nuclear ribosomal RNA large subunit and the RNA polymerase Ⅱ second largest subunit sequences. The phylogenetic reconstruction resolved accessions of the three species into three independent lineages within the Clavaria. The morphology of the three species is described in detail and is illustrated with line drawings and photographs. Holotypes of the new species are deposited in the Mycological Herbarium of Hunan Normal University. The sequences newly generated in this study have been deposited in GenBank. An updated key to the known Clavaria species in China is provided.
Pharmacological and Pharmacokinetic Studies of Hardwickia binata Roxb. Leaf Extract In Insilico and Invitro Models
Authors: Manimegalai Peraman , Selvam Kuppusamy , Prakash Palanisamy , Kirubakaran Dharmalingam , Shivakumar Muthugounder Subaramanian , SenthilNathan Sengottayan 
Published: May 2022

Abstract
To find new sources of antimicrobial and antioxidant agents, methanol extracts of Hardwickia binata Roxb were evaluated systematically. To the present investigation for potential antibacterial and antioxidant phytochemicals in this study and also ADMET and molecular docking for CADD studies. Our results the polyphenol content (total phenol, total flavonoid) and antioxidant capacity of methanol extracts were examined. Identify skin cancer active sites from Hardwickia binata bioactive compounds using GCMS and molecular docking, network pharmacology. The free radical scavenging activities of the methanol extracts also were highest, with the antioxidant activity becoming significantly greater. Furthermore, in vitro antibacterial experiments against phytopathogens such as Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aureginosa validated LE's antimicrobial efficacy. Compared to the other pathogens Enterococcus faecalis have high zone of inhibition (14 ± 0.54). Chemical composition of crude drug extracts was also performed by identify functional groups such as N–H, C–H, OH, and C = O in the methanol extract. GC-MS investigation revealed the existence of 30 bioactive chemicals and 7 active molecules were identify with ADMET and docking in skin cancer proteins (1P7K and 5OTE) among the phytocompounds, Quinoline, 1,2-dihydro-2,2,4-trimethyl (-4.2 kcal/mol; -4.6 kcal/mol), Hexadecanoic acid, methyl ester (-6. kcal/mol; -6.2 kcal/mol) and 5-Phenyl-2,4-pyrimidinediamine, 2TMS derivative (-8.11 kcal/mol; -7.50 kcal/mol) Hardwickia binata is the best compound for the human skin cancer possessed higher binding energy. Our results indicate that the plants can provide sources of natural compounds and the docking studies were carried out in order to predict the most probable kind of interaction, binding affinities, and orientations of the docked ligands at the target protein's active site.