bluuebunny/crossref_metadata_2025_split huggingface dataset:
Edukasi Metode Peer Group tentang HIV/AIDS terhadap Pengetahuan dan Perilaku Seksual Remaja
Authors: Sartiya Rini Dewi , Muhsinah Sitti , Tahir Rusna 
Published: December 2022

Background: Several big cities in Indonesia stated that almost 50% of teenagers had premarital sex. And what is most astonishing is the widespread circulation of sex videos of teenagers wearing school uniforms on the internet. This phenomenon is motivated by the nature of adolescents who tend to want to try all things that are new and challenging. The high presentation of risky behaviour by adolescents needs to be a serious concern for all groups, considering that the transmission of HIV AIDS occurs mainly through sexual intercourse. This study was to see the effect of peer group education on HIV/AIDS on the knowledge and sexual behaviour of adolescents at SMAN 10 Kendari. Methods: This study used a quasi-experimental design with a pre-post test with a control group approach with 60 respondents. Results: There was a significant difference between the mean knowledge scores of the control and intervention groups before and after the intervention with p-value = 0.006, and adolescent sexual behaviour also showed effective results with p-value = 0.046. Conclusion: The peer education method affects knowledge and sexual behaviour, so this method can be used to educate adolescents so that the flow of information delivery is better.
THE EFFECT OF CONSUMPTION OF PORK (SUS BARBATUS) ON BLOOD PRESSURE, HEMOGLOBIN LEVEL AND TOTAL CHOLESTEROL LEVEL
Authors: Djami Supriati Wila , Loaloka Meirina 
Published: December 2022

Pork is a very difficult meat to digest because it contains a lot of fatÂ andÂ pork causes many diseases, namely hardening of the arteries, increased blood pressure, excruciating chest pain (angina pectoris) and inflammation of the joints and if pork is consumed it can affect the organs in the body.Â This study aims to determine the effect of pork consumption on blood pressure, hemoglobin levels and total cholesterol levels.Â This research was conducted on people who often consume pork in Baun village, Amarasi Barat sub-district, with as many as 51 respondents consisting of 20 males and 31 females.Â Based on the results of the study, it is known that people who often consume pork 3 to 4 times a month have hemoglobin levels within normal limits with a percentage of 66.67%, blood pressure tends to be high with a percentage of 47.06% and high total cholesterol levels with a percentage of 53%. So it can be conclude that consuming pork can increase cholesterol levels in the body blood.
Political Philosophy of Illumination: An Analysis of Political Dimensions in Suhrawardi's Thought
Authors: Reza Adeputra Tohis  
Published: December 2022

Suhrawardi is a renowned philosopher famous for his thoughts on the philosophy of Illumination. His thoughts are contained in his mangnum opus, The Wisdom of Al-Isryq (Hikmat Al-Isryq). This study aims to reveal the prominent aspect of various political dimensions in his work, whose primordial focus was on the aspects of the political system and the concept of power. The political system and the concept of power were then characterized as a political philosophy of Illumination. For this reason, this study not only uses a qualitative method with factual historical study techniques regarding figures but also uses an analytical approach to the theory of sociology of knowledge by Peter L. Berger and Thomas Lucmann and the theory of socio-political philosophy of al-Farabi's emanation. The sociology of knowledge is used to analyze the social dimensions involved in the formation of Suhrawardi's thoughts. Meanwhile, the socio-political philosophy of emanation is used to characterize the system and the concept of political power contained in the Wisdom of al-Isryq. The study concludes that the political system contained in the Illumination philosophy is divine, theocratic, and based on the concept of power in the form of self-control. Keywords: Hikmat al-Isryq, Illumination Political Philosophy, Suhrawardi, Reality, Sociology of Knowledge
KONSEP MOTIVASI BELAJAR DI MASA PANDEMI COVID 19
Authors: Hikmiyah Siti Nafsiatul , Burhanuddin Hamam 
Published: December 2022

The Covid 19 pandemic has changed the education system in Indonesia, especially in the learning process, changes in the learning process will be an impact on the learning patterns as running face-to-face, also on student learning motivation. this research discribe the concept of learning motivation during the Covid 19 pandemic, using a literature review approach, which contains theories relevant to research problems, based on the available literature, especially from articles published in various scientific journals. The data collection using primary sources and secondary sources, analysis using content analysis techniques. As the results, the concept of learning motivation during the Covid 19 pandemic divided into two factors, students have high motivation due to student intelligence factors, student activity, the development of student learning independence, the existence of discipline, and learning is a fun activity. Low student motivation to learn is caused by low intelligence factors, excessive demands, weak discipline, stress, and learning is a tedious activity.
Supporting a person-centred approach in clinical guidelines. A position paper of the Allied Health Community – Guidelines International Network (G-I-N)
Authors: van Dulmen Simone A. , Lukersmith Sue , Muxlow Josephine , Santa Mina Elaine , der Sanden Maria W. G. Nijhuis-van , J. van der Wees Philip 
Published: December 2022

<p><strong>Background </strong>A person-centred approach in the context of health services delivery implies a biopsychosocial model focusing on all factors that influence the person’s health and functioning. Those wishing to monitor change should consider this perspective when they develop and use guidelines to stimulate active consideration of the person’s needs, preferences and participation in goal setting, intervention selection and the use of appropriate outcome measures. </p>
<p><strong>Objective </strong>To develop a position paper that promotes a personcentred approach in guideline development and implementation. </p>
<p><strong>Design, setting and participants</strong> We used three narrative discussion formats to collect data for achieving consensus: a nominal group technique for the Allied Health Steering Group, an Internet discussion board and a workshop at the annual G-I-N conference. We analysed the data for relevant themes to draft recommendations. </p>
<p><strong>Results </strong>We built the position paper on the values of the biopsychosocial model. Four key themes for enhancing a person-centred approach in clinical guidelines emerged: (i) use a joint definition of health-related quality of life as an essential component of intervention goals, (ii) incorporate the International Classification of Functioning, Disability and Health (ICF) as a framework for considering all domains related to health, (iii) adopt a shared decision-making method, and (iv) incorporate patient-reported health outcome measures. The position statement includes 14 recommendations for guideline developers, implementers and users. </p>
Eksperimen Pelat Beton Bertulang Bambu Ampel
Authors: Rohimah Rima Siti , Walujodjati Eko 
Published: December 2022

Kebutuhan Indonesia akan jalan dan akses gedung semakin meningkat, tetapi tidak diimbangi dengan pertumbuhan ekonomi yang seimbang. Oleh karena itu, dicari suatu alternatif yang berbiaya rendah untuk membuat strukturnya kuat dan ringan. Sebagai alternatif untuk pelat beton bertulang baja, komponen non struktural, dan sebagainya, pelat beton bertulang bambu ampel merupakan kombinasi yang efektif. Bambu ampel yang akan digunakan merupakan bambu dengan umur lebih dari satu tahun, kemudian bambu ini akan dibentuk menyerupai tulangan besi polos dengan diameter 8 mm. Selanjutnya dilaksanakan pengujian dengan umur perawatan 28 hari. Penelitian ini bertujuan untuk mengetahui pengaruh bambu haur terhadap kelayakan beton ditinjau dari kekuatan lentur satu arah dan kuat tarik bambu ampel itu sendiri. Penelitian ini dilakukan menggunakan metode eksperimen dan dibuat benda uji sebanyak tiga buah untuk pengujian kuat lentur satu arah dengan dimensi benda uji (10x20x60) cm. Dari hasil penelitian dapat disimpulkan rata-rata besar kuat tarik pada bambu ampel adalah 396,10 MPa dan memenuhi standar tulangan besi polos yaitu minimal kuat tarik sebesar 350 MPa dan kapasitas kuat lentur pelat beton yang didapat dengan mengganti tulangan besi menggunakan bambu ampel adalah 1,16 KNm.
LAMA MENDERITA DENGAN KUALITAS HIDUP PASIEN PPOK
Authors: Hasaini Asni 
Published: December 2022

Background: The number of COPD cases is estimated to be ranked third as the most common cause of death in middle-income countries. The most dominant symptom is shortness so that it can affect social activities that negatively impact the quality of life. Quality of life can decrease with the severity and duration of the patient's diagnosis. Objective: To analyze the relationship between duration of suffering and the quality of life of COPD patients at Ratu Zalecha Martapura. Method: This type of quantitative correlation study with a cross-sectional approach with a sample of 104 COPD patients in Ratu Zalecha Martapura Regional Hospital using Consecutive Sampling. Research instruments using questionnaires and for quality of life using the Saint George Respiratory Questionnaire Chronic Obstructive Pulmonary Disease (SGRQ-COPD) and data analysis using Spearman Rho. Results: There is a relationship between the duration of suffering and the quality of life of COPD patients at Ratu Zalecha Martapura with a value of ρ value = 0.002 and rho value = 0.294. Conclusion: The length of time suffered by the majority of COPD patients in the old category ≥ 3 years by 59.6%, the quality of life of the majority of COPD patients in the poor category by 75%. There is a relationship between the duration of suffering and the quality of life of COPD patients in Ratu Zalecha Martapura with a value of ρ value = 0.002 (ρ value <0.05) and rho value = 0.294.
Latar Belakang: Jumlah kasus PPOK diperkirakan menjadi peringkat ketiga sebagai penyebab kematian tersering di negara berpenghasilan menengah. Gejala yang paling dominan adalah sesak sehingga dapat mempengaruhi aktivitas sosial yg berdampak negative terhadap kualitas hidup. Kualitas hidup dapat menurun sejalan dengan tingkat keparahan dan lama pasien didiagnosis penyakit. Tujuan: Untuk menganalisis hubungan antara Lama menderita dan Kualitas Hidup Pasien PPOK di Ratu Zalecha Martapura. Metode: Jenis Penelitian kuantitatif korelasi dengan pendekatan cross sectional dengan sampel penelitian sebanyak 104 pasien PPOK di RSUD Ratu Zalecha Martapura dengan menggunakan Consecutive Sampling. Instrumen penelitian menggunakan kuesioner dan untuk kualitas hidup menggunakan Saint George Respiratory Questionnare Chronic Obstructive Pulmonary Disease (SGRQ-COPD) dan analisis data menggunakan Spearmans Rho. Hasil: Ada hubungan antara Lama menderita dan Kualitas Hidup Pasien PPOK di Ratu Zalecha Martapura dengan nilai ρ value = 0,002 dan nilai rho = 0,294. Kesimpulan: Lama Menderita Pasien PPOK mayoritas dalam kategori lama ≥ 3 tahun) sebesar 59,6%, Kualitas Hidup Pasien PPOK mayoritas dalam kategori buruk sebesar 75%. Ada hubungan antara Lama menderita dan Kualitas Hidup Pasien PPOK di Ratu Zalecha Martapura dengan nilai ρ value = 0,002 (ρ value <0,05) dan nilai rho = 0,294.
Calcium phosphate-based nanomedicine mediated CRISPR/Cas9 delivery for prostate cancer therapy
Authors: Wei Chao-Gang , Zhang Rui , Wei Lan-Yi , Pan Peng , Zu He , Liu Ya-Zhen , Wang Yong , Shen Jun-Kang 
Published: December 2022

Introduction: Erythropoietin producing hepatocyte receptor A2 (EphA2) is widely presented in the tumor cells, closely related to tumor cell migration, not cell apoptosis and proliferation. Based on its high expression in castration-resistant prostate cancer (CRPC), we herein develop a CRISPR-Cas9-based genome-editing nanomedicine to target erythropoietin producing hepatocyte receptor A2 for the treatment of castration-resistant prostate cancer.Methods: To this end, TAT was designed to stabilize the distribution of calcium, and then bound to ribonucleoprotein (RNP) to form nanoparticles RNP@CaP-TAT.Results: This nanoparticle has a simple synthesis process with good biocompatible, to achieve the knockout of tumor cells (PC-3) targeting erythropoietin producing hepatocyte receptor A2 gene and to effectively suppress the migration of tumor cells.Discussion: This delivery genome editing system provides a promising gene therapy strategy for the treatment of castration-resistant prostate cancer, showing good potential against castration-resistant prostate cancer tumor metastasis. In addition, it can be extended to other types of cancer with highly heterogeneous gene expression.
Development and implementation of a nurse-based remote patient monitoring program for ambulatory disease management
Authors: Coffey Jordan D. , Christopherson Laura A. , Williams Ryan D. , Gathje Shelby R. , Bell Sarah J. , Pahl Dominick F. , Manka Lukas , Blegen R. Nicole , Maniaci Michael J. , Ommen Steve R. , Haddad Tufia C. 
Published: December 2022

IntroductionNumerous factors are intersecting in healthcare resulting in an increased focus on new tools and methods for managing care in patients' homes. Remote patient monitoring (RPM) is an option to provide care at home and maintain a connection between patients and providers to address ongoing medical issues.MethodsMayo Clinic developed a nurse-led RPM program for disease and post-procedural management to improve patient experience, clinical outcomes, and reduce health care utilization by more directly engaging patients in their health care. Enrolled patients are sent a technology package that includes a digital tablet and peripheral devices for the collection of symptoms and vital signs. The data are transmitted from to a hub integrated within the electronic health record. Care team members coordinate patient needs, respond to vital sign alerts, and utilize the data to inform and provide individualized patient assessment, patient education, medication management, goal setting, and clinical care planning.ResultsSince its inception, the RPM program has supported nearly 22,000 patients across 17 programs. Patients who engaged in the COVID-19 RPM program experienced a significantly lower rate of 30-day, all-cause hospitalization (13.7% vs. 18.0%, P = 0.01), prolonged hospitalization &gt;7 days (3.5% vs. 6.7%, P = 0.001), intensive care unit (ICU) admission (2.3% vs. 4.2%, P = 0.01), and mortality (0.5% vs. 1.7%, P = 0.01) when compared with those enrolled and unengaged with the technology. Patients with chronic conditions who were monitored with RPM upon hospital discharge were significantly less likely to experience 30-day readmissions (18.2% vs. 23.7%, P = 0.03) compared with those unmonitored. Ninety-five percent of patients strongly agreed or agreed they were likely to recommend RPM to a friend or family member.ConclusionsThe Mayo Clinic RPM program has generated positive clinical outcomes and is satisfying for patients. As technology advances, there are greater opportunities to enhance this clinical care model and it should be extended and expanded to support patients across a broader spectrum of needs. This report can serve as a framework for health care organizations to implement and enhance their RPM programs in addition to identifying areas for further evolution and exploration in developing RPM programs of the future.
The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure
Authors: Bogdanova Tetiana , Chernyshov Serhii , Zurnadzhy Liudmyla , Rogounovitch Tatiana I. , Mitsutake Norisato , Tronko Mykola , Ito Masahiro , Bolgov Michael , Masiuk Sergii , Yamashita Shunichi , Saenko Vladimir A. 
Published: December 2022

IntroductionA worldwide increase in the incidence of thyroid cancer during the last decades is largely due to papillary thyroid microcarcinomas (MPTCs), which are mostly low-risk tumors. In view of recent clinical recommendations to reduce the extent of surgery for low-risk thyroid cancer, and persisting uncertainty about the impact of radiation history, we set out to address whether clinicopathological characteristics and prognosis of post-Chornobyl MPTCs were changing with regard to: i) the latency period, ii) probability of causation (POC) of a tumor due to radiation, and iii) tumor size.MethodsPatients (n = 465) aged up to 50 years at diagnosis who lived in April, 1986 in six northern, most radiocontaminated regions of Ukraine were studied.ResultsLatency period was statistically significantly associated with the reduction of POC level, tumor size and the frequency of fully encapsulated MPTCs. In contrast, the frequency of oncocytic changes and the BRAFV600E mutation increased. Invasive properties and clinical follow-up results did not depend on latency except for a lower frequency of complete remission after postsurgical radioiodine therapy. The POC level was associated with more frequent extrathyroidal extension, and lymphatic/vascular invasion, less frequent oncocytic changes and BRAFV600E, and did not associate with any clinical indicator. Tumor size was negatively associated with the latency period and BRAFV600E, and had a statistically significant effect on invasive properties of MPTCs: both the integrative invasiveness score and its components such as lymphatic/vascular invasion, extrathyroidal extension and lymph node metastases increased. The frequency of total thyroidectomy, neck lymph node dissection and radioiodine therapy also increased with the larger tumor size. The duration of the latency period, POC level or tumor size did not associate with the chance of disease recurrence.DiscussionIn summary, we did not observe overall worsening of the clinicopathological features or treatment results of radiogenic MPTCs that could be associated with the latency period or POC level, suggesting that radiation history did not strongly affect those in the analyzed MPTC patients. However, the increase in the invasive properties with tumor size indicates the need for individual risk stratification for each MPTC patient, regardless of radiation history, for treatment decision-making.
Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU)
Authors: Hosen S. M. Zahid , Uddin Md. Nazim , Xu Zhihong , Buckley Benjamin J. , Perera Chamini , Pang Tony C. Y. , Mekapogu Alpha Raj , Moni Mohammad Ali , Notta Faiyaz , Gallinger Steven , Pirola Ron , Wilson Jeremy , Ranson Marie , Goldstein David , Apte Minoti 
Published: December 2022

BackgroundPrevious studies have revealed the role of dysregulated urokinase plasminogen activator (encoded by PLAU) expression and activity in several pathways associated with cancer progression. However, systematic investigation into the association of PLAU expression with factors that modulate PDAC (pancreatic ductal adenocarcinoma) progression is lacking, such as those affecting stromal (pancreatic stellate cell, PSC)-cancer cell interactions, tumour immunity, PDAC subtypes and clinical outcomes from potential PLAU inhibition.MethodsThis study used an integrated bioinformatics approach to identify prognostic markers correlated with PLAU expression using different transcriptomics, proteomics, and clinical data sets. We then determined the association of dysregulated PLAU and correlated signatures with oncogenic pathways, metastatic phenotypes, stroma, immunosuppressive tumour microenvironment (TME) and clinical outcome. Finally, using an in vivo orthotopic model of pancreatic cancer, we confirmed the predicted effect of inhibiting PLAU on tumour growth and metastasis.ResultsOur analyses revealed that PLAU upregulation is not only associated with numerous other prognostic markers but also associated with the activation of various oncogenic signalling pathways, aggressive phenotypes relevant to PDAC growth and metastasis, such as proliferation, epithelial-mesenchymal transition (EMT), stemness, hypoxia, extracellular cell matrix (ECM) degradation, upregulation of stromal signatures, and immune suppression in the tumour microenvironment (TME). Moreover, the upregulation of PLAU was directly connected with signalling pathways known to mediate PSC-cancer cell interactions. Furthermore, PLAU upregulation was associated with the aggressive basal/squamous phenotype of PDAC and significantly reduced overall survival, indicating that this subset of patients may benefit from therapeutic interventions to inhibit PLAU activity. Our studies with a clinically relevant orthotopic pancreatic model showed that even short-term PLAU inhibition is sufficient to significantly halt tumour growth and, importantly, eliminate visible metastasis.ConclusionElevated PLAU correlates with increased aggressive phenotypes, stromal score, and immune suppression in PDAC. PLAU upregulation is also closely associated with the basal subtype type of PDAC; patients with this subtype are at high risk of mortality from the disease and may benefit from therapeutic targeting of PLAU.
Impact of mature tertiary lymphoid structures on prognosis and therapeutic response of Epstein-Barr virus-associated gastric cancer patients
Authors: Yin Yi-Xin , Ling Yi-Hong , Wei Xiao-Li , He Cai-Yun , Wang Bing-Zhi , Hu Chun-Fang , Lin Wen-Ping , Nie Run-Cong , Chen Jie-Wei , Lin Jin-Long , Zhou Jie , Xie Juan-Juan , Yun Jing-Ping , Xie Dan , Xue Li-Yan , Cai Mu-Yan 
Published: December 2022

BackgroundEpstein-Barr virus-associated gastric cancer (EBVaGC) exhibits unique histological characteristics within the immune-cell-rich microenvironment, but the role of tertiary lymphoid structure (TLS) in EBVaGC is not yet fully understood.MethodsWe retrospectively identified EBVaGC from 8517 consecutive GC cases from the two top cancer centers in China. Furthermore, we evaluated the prognostic value of TLS in 148 EBVaGC patients from our institute and then validated it in an external cohort (76 patients). TLS was quantified and its relationships with overall survival (OS) and therapeutic response were further analyzed. Multiplex immunofluorescence staining and targeted sequencing were used to characterize the composition of TLS and the genomic landscape, respectively.ResultsIn our study, EBVaGC was observed in 4.3% (190/4436) and 2.6% (109/4081) of GCs in the training and validation cohorts, respectively. TLS was identified in the intratumor (94.6%) and peritumor (77.0%) tissues with lymphoid aggregates, primary and secondary (i.e., mature TLSs) follicles in EBVaGC. Kaplan-Meier analysis showed that mature TLS in intratumoral tissues was associated with a favorable OS in the training and validation cohorts (p &lt; 0.0001; p = 0.0108). Multivariate analyses demonstrated that intratumoral TLS maturation, pTNM, and PD-L1 expression were independent prognostic factors for OS (p &lt; 0.05). Furthermore, the mature TLS was significantly associated with a good response to treatment in EBVaGC patients. Interestingly, the mutation frequency of SMARCA4 was significantly lower in the mature TLS groups.ConclusionsIntratumoral mature TLS was associated with a favorable prognosis and good therapeutic response, suggesting that it is a potential prognostic biomarker and predicts a good therapeutic response in EBVaGC patients.