bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct genomic routes underlie transitions to specialised symbiotic lifestyles in deep sea annelid worms
Authors: Martín-Durán Jose , Moggioli Giacomo , Panossian Balig , Sun Yanan , Thiel Daniel , Martin-Zamora Francisco , Tran Martin , Clifford Alexander , Goffredi Shana , Rimskaya-Korsakova Nadezhda , Jekely Gaspar , Tresguerres Martin , Qian Pei-Yuan , Qiu Jian-Wen , Rouse Greg , Henry Lee 
Published: September 2022

Abstract
Annelids have repeatedly evolved symbioses that allow them to colonise extreme ecological niches, like hydrothermal vents and whale falls. Yet, the genetic principles sustaining these symbiotic lifestyles remain unclear. Here we show that different genomic adaptations underpin the symbioses of phylogenetically related annelids with distinct nutritional strategies. While genome compaction and extensive gene losses distinguish the heterotrophic symbiosis of the bone-eating worm Osedax frankpressi, gene gains define the chemoautotrophic symbiosis of deep-sea Vestimentifera. Endosymbionts ultimately compensate most metabolic deficiencies of the host, which include the loss of pathways to recycle nitrogen and synthesise carbohydrates and amino acids enriched in bones in O. frankpressi. Unlike in chemoautotrophic symbioses, innate immunity genes to acquire and control endosymbionts are reduced in O. frankpressi, which, however, has a unique expansion of matrix metalloproteases to digest collagen. Altogether, our study supports that the type of nutritional interaction influences host genome evolution in highly specialized symbioses.
Challenging diagnostic of an accessory spleen mimicking a retroperitoneal tumor: A case report and review of the literature
Authors: Zouaghi Alia , Miri Rim , Mesbahi Meryam , Zaafouri Haithem , Khanchel Fatma , Cherif Mona , Hadded Dhafer , Riahi Wassim , Benzarti Yazid , Mleyhi Sobhi , Ghedira Feker , Souli Aslem , Chammakhi Chiraz , Maamer Anis Ben 
Published: September 2022

Abstract
Background: The accessory spleen is a congenital defect with an additional splenic tissue to the native spleen due to an incomplete fusion of splenic masses during the embryologic period. The preoperative diagnosis is usually mistaken for a retroperitoneal neoplasm. The aim of the present manuscript is to highlight the diagnostic difficulties of a retroperitoneal spleen.
Case presentation: A 41-year-old woman was admitted to the surgical department for an abdominal mass discovered by auto palpation associated with a left lower quadrant pain. The computed tomographic scan showed a heterogeneous and partially necrotic retroperitoneal mass located along the left primitive iliac vessels. Arterial supply to the mass arose from the aorta and the left iliac vessel. The spleen was normal. MRI examination showed a left retroperitoneal heterogeneous and necrotic mass, surrounding the iliac vessels extended from the aortic to the left iliac bifurcation, hyper vascularized at the arterial time with a peripheral capsule intensely enhanced, and there were two other lateroaortic vascularized masses. The patient underwent laparotomy resection of the retroperitoneal mass. The examination of the specimen concluded to an accessory spleen. The postoperative course was uneventful.
Conclusion: An accessory spleen on the retroperitoneal position is extremely uncommon. Preoperative diagnosis is still challenging. The main misdiagnosis is neoplastic disease.
Electronic Structure and Hyperfine Interactions in Crx NbSe 2 (x = 0.33, 0.5) by DFT studies
Authors: Agzamova Polina , Ogloblichev Vasily 
Published: September 2022

Abstract
The first principles calculations of the electronic structure and hyperfine interactions of CrxNbSe2 (x = 0.33, 0.55) chalcogenides are presented. As a result, the values of the hyperfine fields and the parameters of the quadrupole interaction were determined for different arrangements of chromium ions. Ab initio calculations are compared with data obtained by the nuclear magnetic resonance methods on the 53Cr and 93Nb nuclei. It has been shown that Cr3+ ions have a high degree of hybridization of a1g and eg orbitals of 3d-electrons with 4d and 5s orbitals of niobium.It has been established that two nonequivalent environments of chromium ions coexist in Cr0.33NbSe2 compound.
Maximising sexual wellbeing in cancer care: findings from a qualitative process evaluation exploring healthcare professionals’ views on acceptability and usability of an eLearning resource
Authors: Cassells Claire Victoria , Semple Cherith Jane , Stothers Sheena Ruth , Bingham Sharon Linsey 
Published: September 2022

Abstract
Background
Provision of healthcare professional (HP)-led sexual support in cancer care is lacking. Guidelines recommend that HPs should lead on provision of sexual support; however, HPs report considerable challenges providing this care. Barriers include a lack of awareness around sexual concerns and strategies to help patients with cancer and partners cope, coupled with a lack of relevant training, access to supportive resources and signposting opportunities. To address this gap, the Maximising Sexual Wellbeing| Cancer Care eLearning resource (MSW|CC) was developed. Quantitative evaluation of the MSW|CC has demonstrated efficacy in reducing HPs attitudinal barriers to the provision of sexual support. This qualitative process evaluation seeks to explore the mechanisms that may influence HP engagement with MSW|CC and adoption into practice.
Methods
Semi-structured interviews were conducted with HPs who had completed the MSW|CC and were providing routine cancer care in health and social care settings in Northern Ireland. Interviews were audio-recorded, transcribed verbatim and analysed using reflective thematic analysis.
Results
Seventeen participants were interviewed and four key themes were identified. [1] MSW|CC raises HPs awareness of the need for holistic sexual support as part of routine clinical care, [2] MSC|CC prepares and equips HPs to provide sexual support in cancer care, [3] MSW|CC is coherent, engaging and acceptable and [4] MSW|CC: Moving forward.
Conclusion
Important insights were provided into HPs perspectives on the MSW|CC, lending explanation for attrition rates within a previous study. Participants derived benefits from MSW|CC, deeming it an acceptable resource for implementation and integration by HPs across cancer care settings.
Design and FPGA realization of Incremental Fuzzy controller for Stirred Tank Heater
Authors: Mengesha Yeshiwas Fetene , Haile Endalew Ayenew 
Published: September 2022

Abstract
In this paper, Field programmable gate array (FPGA) realization of fuzzy PI controller for Stirred Tank Heater system is presented. The commonly used PI controller in industry though it is simple for implementation lacks reliability when the dynamics of a system changes with time. Replacing PI controllers with AI systems can lead an effective control of a system even in the presence of model uncertainties. The digital implementation of AI systems in DSP or Microcontrollers have limitations of low computational accuracy and slow processing speed. Now adays, FPGAs are being largely used for digital implementation of algorithms because of their higher computational speed and accuracy. In this paper, fast and novel design approach for rapid prototyping of Fuzzy PI controller for Stirred Tank Heater is presented thoroughly. System Generator SIMULINK add on from VIVADO is used to generate Very High-Speed Integrated Circuit Hardware Description Language (VHDL) directly from MATLAB. The developed controller for stirred tank system is verified in Fixed point arithmetic using Xilinx Simulink blocks. The VHDL code is then generated, synthesized, implemented and made ready for physical implementation on Kintex-7 evaluation board.
Psychological Assessment of a Sample of Relatives of People with Borderline Personality Disorder Compared to Relative of People without Psychological Disorders
Authors: Guillen Veronica , Bolo Sara , Fonseca-Baeza Sara , Pérez Sandra , García-Alandete Joaquin , Marco Heliodoro , Botella Cristina 
Published: September 2022

Abstract
Background: To date, several evidence-based interventions have been created to help relatives of people with Borderline Personality Disorder (BPD), but few studies have analyzed the clinical situation of the family members. The aim of this study was to explore the possible existence of clinical symptomatology in a sample of relatives of people with BPD and compare it to a sample of relatives of the general population. The second aim was to explore the personality of the relatives in order to determine whether they have dysfunctional personality traits or meet the diagnostic criteria for PD. Method: The sample consisted of a total of 106 relatives, 60.4% were mothers, and 39.6% were fathers. The sample of relatives of the clinical population was selected from relatives of patients attending a Specialized PD Unit for treatment. The sample of relatives of the normal population was obtained with the collaboration of third- and fourth-year psychology students. To test for differences between the two groups, Student's t tests were performed for quantitative and quasi-quantitative variables, and chi-square (χ2) tests were performed for categorical variables. In addition, Cohen's d was calculated as a measure of the effect size.
Results: The results showed that family members of people with BPD present greater depressive and anxious symptomatology, higher levels of expressed emotion, and worse quality of life than the control group. In addition, a high percentage of the clinical sample (50%) met the diagnostic criteria for different Personality Disorders.
Conclusions: These data suggest that relatives may need psychological help in various aspects. Therapists are therefore advised to bear in mind the importance of carrying out a psychological assessment of family members and, if necessary, to offer psychological intervention. It is crucial to invite the family to be part of the treatment, they are part of the solution.
Trial registration: ClinicalTrials.gov ID: NCT04160871. Registered November 15th 2019.
Simultaneous saccharification and fermentation (SSF) of waste bread by an amylolytic Parageobacillus thermoglucosidasius strain TM333
Authors: Ibenegbu Christopher C. , Leak David J. 
Published: September 2022

Abstract
The starch in waste bread (WB) from industrial sandwich production was directly converted to ethanol by an amylolytic, ethanologenic thermophile (Parageobacillus thermoglucosidasius strain TM333) under 5 different simultaneous saccharification and fermentation (SSF) regimes. Crude α-amylase from TM333 was used alone or in the presence of amyloglucosidase (AMG), a starch monomerizing enzyme used in industry, with/without prior gelatinisation/liquefaction treatments and P. thermoglucosidasiusTM333 fermentation compared with Saccharomyces cerevisiae as a control. Results suggest that TM333 can ferment WB using SSF with yields of 94-100% of theoretical (based on all sugars in WB) in 48h without the need for AMG addition or any form of heat pre-treatment. This indicates that TM333 can transport and ferment all of the malto-oligosaccharides generated by its α-amylase. In the yeast control experiments, addition of AMG together with the crude α-amylase was necessary for full fermentation over the same time period. This suggests that industrial fermentation of WB starch to bio-ethanol or other products using an enhanced amylolytic P. thermoglucosidasius strain could offer significant cost savings compared to alternatives requiring enzyme supplementation.
Assessment of the Impacts of Climate Change on Water Supply System Pipe Failures
Authors: Fan Xudong , Zhang Xijin , Yu Allen , Speitel Matthew , Yu Xiong 
Published: September 2022

Abstract
Climate change is projected to have profound impacts on the resilience and sustainability of built infrastructure. This study aims to understand the impacts of climate change on water supply systems and to facilitate adaptive actions. A premium database maintained by the Cleveland Water Division, Cleveland, Ohio, USA is analyzed. It contains 29,621 pipe failure records of 51,832 pipes over the past 30 years, representing one of the largest dataset in current literature. From the database, pipe failure rate models have been developed for water pipes made of different types of materials at different ages. The influence of climate (temperature and precipitation) on fragility of water pipes are obtained. Based on the developed climate-fragility failure rate models, the impacts of climate change on the water systems located in different geographic regions are evaluated by predicting the failure rate and number of failures in the water systems in the next 80 years (2020 to 2100). Climate models are used to predict weather under different climate change scenerios. The results demonstrate that the impacts of climate change on water supply system are likely complicated and are dependent upon factors such as the geographic location, pipe material, pipe age, and maintenance strategies. Water pipes in the cold regions may experience less number breaks due to the warmer weather and less servere winter, whereas those located in the hot regions may experience more failures associated with more corrosion. Different pipe replacement strategies are compared, which demonstrate the importance of considering the aging of water supply system in future maintenance decisions. This study enriches current understandings on the impacts of climate change on the water systems. The results will help water utilities to design climate change adaptation strategies.
Evaluation of Joint External Evaluation to COVID-19 and other infectious diseases mortality outcomes in 96 countries
Authors: Lee Yuri , Kim Siwoo , Lee Sieun , Kim Min Kyung , Gostin Lawrence O. , Oh Juhwan 
Published: September 2022

Abstract
Background
This study assessed the association between Joint External Evaluation (JEE) scores and Covid-19 and other infectious diseases performance in 96 countries. To propose a revised JEE tool, potential JEE indicators were also examined.
Methods
The JEE scores were extracted across 96 countries from 2016 to 2019. We used Covid-19, fatality rate, infections per million, and deaths per million as main outcomes. Influenza, pneumonia, HIV, tuberculosis, malaria, Hepatitis B, and childhood vaccinations were included as other infectious diseases performance. Sustainable Development Goals (SDGs), Universal Health Coverage (UHC) index and others were reviewed as potential JEE indicators. We used multiple regression to assess the association between JEE scores and Covid-19 and infectious diseases performance. Then, Covid-19 outcomes and influenza and pneumonia mortality rates were regressed on potential JEE indicators.
Results
An average JEE score was 2.70 (SD = 0.92) in 96 countries. The detection (3.23) and other areas (2.30) sections received the highest and the lowest score, respectively. A positive association between the Covid-19 outcomes and the JEE scores was found. However, JEE scores and the other infectious diseases performance showed a negative association. The SDGs 2,4, and 8 were strongly associated with Covid-19 outcomes.
Conclusion
The JEE scores showed poor predictive value against the Covid-19 mortality outcomes in 96 countries. Thus, a revised JEE tool is needed to better prepare for future public health crisis.
Deep learning predicts patients’ outcome and mutations from H&amp;E slides in Gastrointestinal stromal tumor (GIST)
Authors: fu yu , Karanian Marie , Perret Raul , Camara Axel , Loarer François Le , Jean-Denis Myriam , Hostein Isabelle , Michot Audrey , Ducimetiere Françoise , Giraud Antoine , Courreges Jean-Baptiste , Courtet Kevin , LAIZET Yech'an , Bendjebbar Etienne , Du Terrail Jean Ogier , Schmauch Benoit , Maussion Charles , Blay Jean Yves , Italiano Antoine , Coindre Jean-Michel 
Published: September 2022

Abstract
Background. Most gastrointestinal stromal tumors (GIST) have activating mutations of KITor PDGFRA genes and imatinib has proven effective in palliative and adjuvant situations. Risk assessment according to the AFIP/Miettinen classification and mutational profiling are major tools for management of patients with GIST. However, the AFIP/Miettinen classification depends heavily on mitotic counts, which is laborious and sometimes inconsistent between pathologists. It has also been shown to be imperfect in stratifying patients. Molecular testing is costly and time consuming, therefore not systematically performed in all countries. New methods to improve risk and molecular predictions are hence crucial to improve the tailoring of adjuvant therapy.
Methods. We have built deep learning (DL) models on digitized H&E-stained whole slide images (WSI) to predict patients’ outcome and mutations. Models were trained with a cohort of 1233 GIST and validated on an independent cohort of 286 GIST. All WSIs from center 1 are available under controlled access at the European Genome-phenome Archive via accession number X(process is ongoing, will be completed at publication).
Results. DL models outperformed the Miettinen classification for relapse-free-survival prediction in localized GIST without adjuvant Imatinib (C-index=0.83 in testing and 0.72 for independent validation). DL splitted Miettinen intermediate risk GIST into high/low risk groups(p-value=2.1e-03). DL models achieved an area under the receiver operating characteristic curve (AUC) of 0.81, 0.91 and 0.71 for predicting mutations in KIT, PDGFRA and wild type respectively in testing and 0.84, 0.93 and 0.56 in independent validation. Notably, PDGFRA exon18 D842V mutation which is resistant to Imatinib, was predicted with an AUC of 0.87 and 0.90 in testing and independent validation, respectively. Additionally, novel histological criteria predictive of patients’ outcome and mutations were identified by reviewing the tiles selected by the models.
Conclusions. Our results strongly suggest that implementing DL with digitized WSI may represent a reproducible way to improve tailoring therapy and precision medicine for patients with GIST.
An Iceberg I can’t handle: A qualitative inquiry on perceptions towards paediatric rheumatology among healthcare workers in Kenya.
Authors: MIGOWA ANGELA NYANGORE , Bernatsky Sasha , Ngugi Anthony , Foster Helen E , Muriuki Peterrock , Lusambili Adelaide , Luchters Stanley 
Published: September 2022

Abstract
Background
Delay in diagnosis and access to specialist care are huge problems for many children and young people with rheumatic disease in sub-Saharan Africa. Most children with symptoms of rheumatic disease present to non-specialists for care. There is an urgent need to understand and scale-up paediatric rheumatology knowledge and skills amongst non-specialist clinicians, to promote early diagnosis, prompt referral, and management.
Purpose
We evaluated the knowledge, attitudes and practices towards diagnosis and care of paediatric rheumatology patients among health care workers in Kenya.
Methods
We conducted 12 focus group discussions with clinical officers (third-tier community health workers) nurses, general practitioners and paediatricians across 6 regions in Kenya. Interviews were conducted on zoom, audio-recorded, transcribed, and analysed using NVIVO software.
Results
A total of 68 individuals participated; 11 clinical officers, 12 nurses, 10 general practitioners, 27 paediatricians and 7 others. Most (n = 53) were female, and the median age was 36 years (range 31–40 years). Half the participants (34 of 68) worked in public health facilities. Our study revealed gaps in knowledge of paediatric rheumatology amongst healthcare workers, which contributes to late disease diagnosis and poor management. Healthcare workers reported both positive and negative attitudes towards diagnosis and care of paediatric rheumatological diseases. Perceived complexity and lack of knowledge in the diagnosis and management, in addition to unclear health system clinical pathways, made all cadres of healthcare workers feel helpless, frustrated, inadequate and incompetent to manage paediatric rheumatology patients. Positive attitudes arose from a perceived feeling that paediatric rheumatology patients pose unique challenges and learning opportunities.
Conclusion
There is an urgent need to educate healthcare workers and improve health systems for paediatric rheumatology patients.
Prevalence of dietary supplements consumption among CrossFit practitioners
Authors: Quaresma Marcus V.L. Dos Santos , Marques Camila Guazzelli , Magalhães Ana Carolina Oumatu , Cirillo Letícia , Ciudi Roberta Beltrame , Oliveira Lucas Scalabrin , Santos Ronaldo Vagner Thomatieli dos , Nakamoto Fernanda Patti 
Published: September 2022

Abstract
Purpose: We aimed to determine the prevalence of the use of supplements among CFPs. Moreover, we sought to elucidate which factors may be associated with dietary restraint, a dimension of eating behavior that seems to be crucial for food intake, energy availability, fatigue, and performance.
Methods CFPs aged 18-64 years (n = 112; 57 male; 55 female) were included in this cross-sectional, exploratory, and descriptive study. They answered an online questionnaire containing questions to assess prevalence, type, and reasons for supplements use, besides information about sociodemographic variables and prevalence of the main chronic morbidities. To analyze aspects of eating behavior, the “Three-factor eating questionnaire (TFEQ) - R21" was used. The Pittsburgh Sleep Quality Index questionnaire (PSQI) was used to assess sleep time and quality.
Results: Eighty-seven CFPs (50 male; 37 female) reported currently use of dietary supplements. Whey protein was the most used supplement (n = 70), followed by creatine (n = 54). Eating behavior dimensions of emotional eating, binge eating, and cognitive restraint displayed no differences between genders and CFPs of levels.
Conclusion: CFPs seem to be using some supplements with purposes which conflict with those supported by scientific evidence. Regarding eating behavior dimensions, physical exercise may be able to suppress emotional eating, possibly justifying the lack of difference in our results. The use of supplement is prevalent among CF practitioners, but it seems they need nutrition education.
Anatomic Variations Of The Superior Thyroidal Artery Origin And Its Clinical Effects: A Study In 375 Selective Carotid Angiograms
Authors: Eraslan Önder , Ergun Onur , Birgi Erdem , Temir Ertan , Durmaz Hasanali , Conkbayır Işık , Hekimoğlu Baki 
Published: September 2022

Abstract
The authors have requested that this preprint be removed from Research Square.