bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of prodigiosin on staphylococcus aureus isolated from acne vulgaris
Authors: Ali Mustafa Hussein , Al-Attar Nagham Shakir 
Published: June 2022

Acne is a skin disorder characterized by clogged hair follicles and chronic inflammation of the pilosebaceous follicles. A total of one hundred and five acne swabs were collected from patients with acne vulgaris infection at Baghdad's hospitals. For primary identification, 54 (45%) samples had a positive S. aureus culture on Mannitol salt agar (MSA) for 24 hours at 37°C. In addition, four pre-isolated also identified S. marcescens (pigment producers) which were identified by vitek-2 technique were taken for prodigiosin extraction, mineral salt broth with peptone (0.5 percent) was utilized, followed by pigment extraction, partial purification, also pigment measurement by spectrophotometer. Furthermore, using a microtiter plate assay, the bacterial ability to form biofilms was assessed for 20 S. aureus isolates (multidrug resistant isolates). The results revealed that only 8 strong isolates were biofilm producers, while 5 in addition 7 isolates were moderate also weak biofilm producers. The minimal inhibitory concentration of tetracycline also prodigiosin generated by isolated S. marcescens were determined using the broth microdilution technique for S. aureus isolates (S7 also S8). From overnight cultures of S. aureus (S7 also S8), DNA was effectively extracted.
Evaluation the role of MicroRNAs in diagnosis and prognosis of acute myeloid leukemia
Authors: Muhammid Hind Salih , Hassan Alaa Jawad , Abdulla Hussein Naji 
Published: June 2022

Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic progenitor cells which are characterized by relevant heterogeneity in terms of phenotypic, genotypic, and clinical features. Among the genetic aberrations that control disease development there are microRNAs (miRNAs). The present study aimed to investigate the role of miRNAs in diagnosis and prognosis of AML and it was designed as cross sectional study in patients with acute myeloid leukemia and normal individuals as control group, we determined: RNA yield and quality; and quantification of miRNA-203, miRNA-143, and miRNA-495 expression by Quantitative Real-Time PCR (qPCR) in the serum of AML patients and control groups. The study was conducted in period between December 2020 and September 2021 at the University of Babylon, College of Science, department of biology. In this case-control study, blood samples were collected from 115 AML patients (38 male and 77 female) and their ages ranged between 18 and 66 years , then, 60 patients were selected based on the quantity and natural color of their samples (28 male and 32 female), in addition to the 30 samples from healthy apparently subjects as a control group (11 male and 19 female), and this group matched with the patients groups.
Evaluating the levels of interleukin-6 and interleukin-10 as potential biomarkers for the severity and mortality in COVID-19 patients
Authors: Al-Hatemy Mohammed Dakhil Bareez , Mohsin Muslim Idan 
Published: June 2022

Objective: Evaluating the levels of pro-inflammatory cytokine (IL-6) and anti-inflammatory cytokine (IL-10) among patients with COVID-19. Methodology: A study is conducted during the period from 1st November 2021 to 1 st April 2022 , 110 patients were diagnosed as COVID-19. Their ages range between 20-81 and more years old, Who attended to AL-Amal Specialized Hospital for Communicable Diseases at first week of infection with symptoms (fever, Headache, cough, shortness of breath, diarrhea, loss of taste and smell), and compared with 50 apparently healthy individuals as control group. The diagnosis of each case was established using clinical diagnosis and confirmed by reverse transcriptase polymerase chain reaction (rt-PCR), 5 ml of fresh venous blood samples were collected from COVID-19 infected patients by sterile syringes and saved in serum separator tube (SST) with specific gel to easy sorting the serum, then left for 20 minutes at room temperature. After coagulation, sera were separated by centrifuge 4000xg for 15 minutes and directly stored at -20 ºC to be analyzed later for IL-6 and IL-10 assay.
Metallothionein gene polymorphism is considered to be a risk factor for chronic diseases
Authors: Hamed Owayes M. , Khalil Mohammed I. , Alsaffar Raed S. 
Published: June 2022

Metallothioneins are considered the main proteins to protect the cell from toxins like heavy metals and oxidative stress encoded by the Metallothionein gene. Any mutation in this gene leads to a defect in the function of Metallothionein proteins, leading to an increase in the effect of heavy metals. Reactive oxygen species, the SNP A-G (rs28366003) in promotor of the metallothionein gene converts the A allele to G allele, and therefore decreases the transcription qualification of the Metallothionein gene; the aim of the study is correlation between A-G (rs28366003) polymorphism in promotor of Metallothionein gene and the risk factor as well as detecting the levels of heavy metals in patients with Kidney failure, this study includes 60 persons with Kidney failure and 20 persons as a control group with age gape (30-55) years, the blood sample collects from the subject and separate into two-tube, EDTA tube to extraction the DNA and Gel tube to biochemical test. The result showed that there is a relationship between polymorphism in the promotor of the Metallothionein gene in the site A-G (rs28366003). The distribution of different genotypes is wild A.A. 22 %, hetero AG 25%, and mutant 53% in the patients.
Research performance on COVID 19 in dimensions database
Authors: Jeyapragash B. , Sivakumaren K. S. 
Published: June 2022

The coronavirus disease 2019 (COVID-19) pandemic aroused global public concern and became a major medical issue. This study aims to investigate the global research output and trends of coronavirus over the last fifty years based on the productivity. The Lancet is an independent, international weekly general medical journal founded in 1823 by Thomas Wakley. The Lancet has an Impact Factor of 79·321 and ranks second among 169 general and internal medicine journals globally. The Lancet Journal articles on coronavirus published from 1971 to 2021 were extracted from Dimensions Database for the study. This study aims to analyze the Lancet research productivity of COVID 19, Year wise publications and Citations, Top twenty five researchers, Altmetric Score for top twenty five articles and highly cited research publications. A total of 1435 coronavirus articles originated from 1061 researchers in various countries and the publications received 133294 citations. The highest number of (898 (62.58%)) articles were produced in the year 2020. The highest number of (85060 (63.81%)) citations received in the year 2020. The “Richard C Horton” has contributed highest number of (32 (2.23%)) articles and received 271 citations.
AIN and role of steroids
Authors: Yaqub Soniya 
Published: June 2022

BACKGROUND:
Acute interstitial nephritis (AIN) is a potentially reversible, but under-diagnosed cause of acute kidney injury. The role of steroids in the management of drug-induced AIN is debatable. There is scarcity of data on clinical characteristics of drug induced AIN, and role of steroids and its impact on renal outcomes from the developing countries.
METHODS:
We performed a retrospective study of patients with biopsy proven AIN over a period of 11 years. The main outcomes were recovery of renal function (Early (≤3 weeks) or Late (>3 weeks) and hemodialysis (HD) dependence at 12 weeks.
Совершенствование бизнес процессов в системе электронного здравоохранения
Authors: Аскаров Куандык 
Published: June 2022

Целью исследования заключалась в актуализации интеллектуального соучастия машинного составляющего медицинских информационных систем в связи с избытком функций и сложностью в их освоении.
Материалы и методы. В данном исследовании применялся метод анализа состояния медицинских информационных систем и их техническое обоснование для адаптации в системе автоматического управления, где объектом исследования явились процессы преобразование моделей в действующих медицинских информационных системах.
Результаты. Медицинские информационные системы являются оптимальным решением для развития современной медицины. Благодаря своим разнообразным функциям медицинские информационные системы повышают эффективность работы врачей, выездных бригад скорой медицинской помощи, работников регистратуры и пунктов приема пациентов, сотрудников организационно-методического отдела, бухгалтеров и так далее.
Согласно цели исследования необходимо обеспечить оптимальное применение существующих алгоритмов автоматизированных систем учета. С точки зрения проактивной работы, в настоящее время медицинские информационные системы обладает рядом недостатков, основным из которых является избыточность функций и, как следствие, сложность в освоении разнообразной информации и сниженный потенциал интеллектуального соучастия машинного составляющего медицинской информационной системы.
Цифровизация всех сведений о пациенте способна минимизировать риски, связанные с раскрытием врачебной тайны о состоянии здоровья пациента, и позволит врачам оперативно осуществлять обмен информацией в условиях единого информационного пространства системы здравоохранения.
Заключение. Медицинские информационные системы нуждаются в структурировании, хранении и организации эффективного поиска информации не только в базе данных, но и в базе знаний. Необходимо обеспечить равнозначность электронного и бумажного документооборота, а также исключить дублирование документов на электронных и бумажных носителях.
Application of Kolcaba’s theory of comfort in nursing practice
Authors: Әуезханқызы Дана , Гульбинене Юргита , Рикликене Ольга 
Published: June 2022

In 21st Century nursing is the bridge that holds a patient's health care process together. The important task for nurses is to determine patients’ needs and to satisfy them in a timely manner and a good quality. The comfort of a patient is a fundamental need that determine functionality, quality of life and health care outcomes of individual. The comfort theory developed by Katharine Kolcaba provides the essential assumptions and theoretical underpinings that might be helpful dealing with clinical, educational, scientific and managerial issues.
Aim: the aim of this study was to analyze the application of Kolcaba’s Theory of Comfort for nursing research, education, practice and leadership.
Methods: a theoretical-reflective essay conducted in a dialectical process between relevant literature, theoretical framework and reflection.
Results: Kolcaba's Theory of Comfort has been successfully applied in nursing research, education, nursing practice and leadership. The majority of studies with Comfort Theory were concerned with the effects of interventions on the patient’s level of comfort.
Conclusion: Kolcaba's Theory of Comfort is totally applicable in nursing research, education, clinical nursing practice and leadership initiatives in the health care organisations. By utilising Comfort theory in health care institutions in Kazakstan nurses can create a positive atmosphere for the comfort of each patient assuring respect for his present and past, for his life values, traditions and beliefs. The principles of theory might be integrated into undergraduate and postgraduate nursing education programs.
Характеристика смертельных исходов от коронавирусной инфекции в Казахстане
Authors: Турбекова Мира , Камхен Виталий , Малгаждаров Маулен 
Published: June 2022

Цель настоящего исследования заключалась в изучении особенностей структуры и динамики смертельных исходов от коронавирусной инфекции, а также, особенностей выживаемости населения Республики Казахстан при данной патологии.
Материалы и методы. На основании популяционных регистровых данных проанализирована доля случаев смерти по полу, возрасту, с учетом места смерти (в стационаре, на дому, в другом месте), а также частота случаев смерти в регионах РК. Проводился расчет удельного веса и стандартной ошибки среднего. Для выполнения анализа выживаемости использовался метод построения таблиц дожития и метод Каплана-Мейера (медианное время дожития, доля умерших, кумулятивное дожитие).
Результаты. В 2020 г. наибольшая доля терминальных случаев от инфекции COVID-19 зарегистрирована в г. Алматы, г. Шымкент, Восточно-Казахстанской области и наименьшая доля – в Кызылординской области, Северо-Казахстанской области, Туркестанской области, а в 2021 г. наибольшая частота случаев смерти зарегистрирована в г. Алматы, г. Нур-Султан, г. Шымкент, Карагандинской области и наименьшая частота – в Туркестанской области, Костанайской области, Восточно-Казахстанской области. наименьшее дожитие характерно для Туркестанской обл. (в 2020 и 2021 гг.), наибольшее дожитие – для Северо-Казахстанской обл. (в 2020 г) и Западно-Казахстанской обл. (2021 г.) и г. Нур-Султан (в 2021 г.).
Заключение. Основной вывод, который можно сделать, заключается в том, что необходим больший охват населения вакцинацией от короновирусной инфекции в возрастной группе «60-80 лет», а также постоянное наблюдение за группой больных пожилого возраста.
Effect of Nickel Concentration on Ozone Production using Nickel-Antimony Doped Tin Oxide for Wastewater Treatment
Authors: Maneelok Supandee , S. Attidekou Pierrot 
Published: June 2022

Nickel-antimony doped tin oxide (NATO) catalyst has greatly considered its capability to treat high organic matter and eliminate colour in wastewater as palm oil mill wastewater with electrochemical ozone generation. This study presents the optimal Ni content of NATO and its properties to enhance ozone generation. The NATO anodes were fabricated by dip-coating, varying the Ni content between 0.5% and 5%. The key findings show that all anodes showed a single phase of rutile structure with the cracked mud on the surface. The binding energies of the Sb3d3/2 peak at 540.48 eV and 541.58 eV agree with Sb3+ and Sb5+, respectively. The optimal ozone current efficiency of 37% at the current density of ca. 0.22 A cm-2 in 0.5 M H2SO4 at 2.7V was obtained on the NATO anode with 2% Ni content calcined at 700 oC. The palm oil mill wastewater treatment result showed that decolourisation TOC and COD removal efficiency increased with increasing electrolysis time. The colour removal efficiency achieved was more than 85% for a reaction time of 15 min. The efficiency of TOC and COD removal was reached ca. 80% in 20 min. The overall results appeared that NATO with electrochemical ozone generation could be employed to treat palm oil mill wastewater with high efficiency due to •OH and O3.
History of Western Academic Reaserchs on Yārsān 1836-2020
Authors: ZAHEDİ MOGHADAM Alireza 
Published: June 2022

The Yārsān (Yāresān or Yāristān) or Ahl-i Haqq (Believers of the Truth) are a religious minority whose traditions and beliefs have received some attention from academics over the last century.
Geranpayeh writes: "The religion of the Yārsān is an Iranian religion that has its own peculiarities in its sacred poems and speeches, songs and rituals in the Middle East. The oral literature of the Yārıstān, which also includes the description of their rituals, is in Gūrānī, in Handed down in Persian and in Loric as well as in a Turkish dialect."
Pre-induction: Are there differences in the use and implementation of the electronic medical record in relation to the level of training and work experience? Experiences in the nursing staff of a private oncohematological institution
Authors: Pérez Vargas Patricia Elizabeth , Valdés Rojas Juan Celestino , Vasallo Valverde Jennifer Caridad , López Suárez Rosbelys , Ares Laura Camila 
Published: June 2022

Introduction: induction is the knowledge that the person entering should acquire regarding the history of the organization, its structure, marketing and commercial scheme; company policies regarding personnel, hygiene and safety, environment; occupational health programs, quality, culture, mission, values. Objective: to describe the perception of induction in the use of the oncohematologic electronic health record (EHR) for the safe administration of antineoplastic chemotherapy. Methods: descriptive, cross-sectional research; the sample consisted of 55 units of analysis. A semi-structured questionnaire was used as an instrument. Results: there is a statistically significant difference in the perception of organizational culture (p=0,040) and between seniority in the institution with the induction of EHR training (p=0,012), with professional nurses of 1,26±0,44 and for Licensed 1,06±0,24, seniority in the institution ranged in groups of 1-4 years and 5 to 9 years. Cytostatic preparation and seniority in the institution (p=0,020). The group with more than 25 years of seniority in the institution have the responsibility for the preparation of cytostatics 4,90±0,30 (p<0,05). Conclusions: It is not homogeneous how the organizational culture is perceived by the different professional levels. In relation to seniority, the majority are female, graduates and young adults. EHR induction is perceived by professionals as an institutional strategy for patient safety culture. Likewise, EHR practices show that it is used by qualified personnel in the administration of cytostatics
Phosphorylated alpha‐synuclein in Iba1‐positive macrophages in the skin of patients with Parkinson's disease
Authors: Oizumi Hideki , Yamasaki Kenshi , Suzuki Hiroyoshi , Ohshiro Saki , Saito Yuko , Murayama Shigeo , Sugimura Yoko , Hasegawa Takafumi , Fukunaga Kohji , Takeda Atsushi 
Published: June 2022

AbstractBackgroundIncreasing evidence suggests that alpha‐synuclein (αSyn) accumulation in cholinergic and adrenergic fibers in the skin is a useful biomarker to diagnose idiopathic Parkinson's disease (IPD). It has been widely reported that phosphorylated αSyn (p‐αSyn) deposits in autonomic fibers in IPD are a biomarker in the skin, but other tissue localizations have not been fully investigated.ObjectiveIt has been previously suggested that αSyn aggregates activate peripheral macrophages and that peripheral macrophages ingest pathological αsyn aggregates in aged rats or IPD patients. However, it remains to be elucidated whether peripheral macrophages in the skin of IPD patients accumulate αSyn. We evaluated whether (1) p‐αSyn deposits in dermal macrophages might represent a useful biomarker for IPD and (2) dermal macrophages play a role in the underlying pathogenesis of IPD.MethodsWe performed an immunohistological analysis of skin biopsy specimens from IPD patients and controls.ResultsWe found that (1) p‐αSyn accumulation is present in dermal macrophages in skin biopsy specimens from patients with IPD, (2) not only dermal adrenergic fibers with p‐αSyn deposits but also dermal macrophages with p‐αSyn deposits are useful biomarkers for IPD patients and (3) the number of macrophages was significantly positively correlated with the number of macrophages with p‐αSyn deposits in the dermis of IPD patients.InterpretationOur results suggest that dermal macrophages, which are innate immune cells, play an important role in IPD patients and are a novel biomarker for IPD.
High Spin Hall Conductivity Induced by Ferromagnet and Interface
Authors: Li Rongxin , Yuan Xiaojuan , Tu Huayao , Zhang Zhenhua , Luo Yanxiang , Chen Qian , Li Shangkun , Liang Shiheng , Liu Yong , Lu Zhihong , Zeng Zhongming , Xiong Rui 
Published: June 2022

AbstractSpin‐orbit‐torque (SOT) offers a highly attractive perspective for manipulating magnetization dynamics in magnetic nanostructures. SOT is been observed and studied in various systems. However, limited by the efficiency, SOT‐induced switching of the ultrahard ferromagnet is still extremely difficult and a further improvement in efficiency is requested. Here, the SOT is reported in chemically disordered soft Fe0.5Pt0.5 and Pt/Fe0.5Pt0.5 bilayers. Due to the magnetization‐strengthened spin Hall effect, the damping‐like torque efficiency and spin Hall conductivity (SHC) in Fe0.5Pt0.5 reach 1.11 and 1.08 × 106 ℏ/2e Ω−1 m−1 respectively, much higher than those in conventional materials. Furthermore, the Pt/Fe0.5Pt0.5 interface enhances SHC to a total of 2.93 × 106 ℏ/2e Ω−1 m−1 due to the interfacial symmetry breaking. This system can be used to partially switch the magnetization of ultra‐hard exchange‐spring system with a switching field of 1T by applying a relatively low current. This finding will push forward the development of SOT devices with ultrahigh‐density and low‐power consumption.
Hydrogel Combined with Phototherapy in Wound Healing
Authors: Xu Yinglin , Chen Haolin , Fang Yifen , Wu Jun 
Published: June 2022

AbstractWound healing is a complex biological process that involves tissue regeneration. Traditional wound dressings are dry, cannot provide a moist environment for wound healing, and do not have high antibacterial properties. Hydrogels, which are capable of retaining large amounts of water, can create a moist healing environment. Currently, phototherapies have exhibited a high potential for the treatment of bacterial infections. Therefore, combining hydrogels with phototherapy can adequately overcome the shortcomings of traditional wound treatment methods and show great potential for wound healing owing to their high efficiency, low irritation, and good antibacterial performance. In this review, the application of hydrogels combined with phototherapy in wound healing is summarized. First, the basic principles of photodynamic therapy and photothermal therapy are briefly introduced. In addition, the progress of the application of hydrogel combined with phototherapy in wound healing is systematically investigated. Finally, the challenges and prospects of combining hydrogel with phototherapy in wound healing are discussed.
Correlative Analysis of Intra‐ Versus Extracellular Cell Detachment Events via the Alignment of Optical Imaging and Detachment Force Quantification
Authors: Weigl Franziska , Blum Carina , Sancho Ana , Groll Jürgen 
Published: June 2022

AbstractIn recent decades, hybrid characterization systems have become pillars in the study of cellular biomechanics. Especially, Atomic Force Microscopy (AFM) is combined with a variety of optical microscopy techniques to discover new aspects of cell adhesion. AFM, however, is limited to the early‐stage of cell adhesion, so that the forces of mature cell contacts cannot be addressed. Even though the invention of Fluidic Force Microscopy (FluidFM) overcomes these limitations by combining the precise force‐control of AFM with microfluidics, the correlative investigation of detachment forces arising from spread mammalian cells has been barely achieved. Here, a novel multifunctional device integrating Fluorescence Microscopy (FL) into FluidFM technology (FL‐FluidFM) is introduced, enabling real‐time optical tracking of entire cell detachment processes in parallel to the undisturbed acquisition of force‐distance curves. This setup, thus, allows for entailing two pieces of information at once. As proof‐of‐principle experiment, this method is applied to fluorescently labeled rat embryonic fibroblast (REF52) cells, demonstrating a precise matching between identified force‐jumps and visualized cellular unbinding steps. This study, thus, presents a novel characterization tool for the correlated evaluation of mature cell adhesion, which has great relevance, for instance, in the development of biomaterials or the fight against diseases such as cancer.