bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial neutrophil/lymphocyte and lymphocyte/monocyte ratios can predict future insulin need in newly diagnosed type 1 diabetes mellitus
Authors: Erbaş İbrahim Mert , Hajikhanova Aygün , Besci Özge , Acinikli Kübra Yüksek , Demir Korcan , Böber Ece , Abacı Ayhan 
Published: March 2022

Abstract

Objectives
The exact mechanism of partial clinical remission in type 1 diabetes mellitus (T1DM) has not been elucidated yet. The severity of the inflammation at the time of diagnosis may affect the occurrence or duration of this phase. We aimed to investigate the relationship between hematological inflammatory parameters at the time of diagnosis in T1DM and (i) daily insulin requirement during the follow-up and (ii) the presence of partial clinical remission period, which was determined according to insulin dose-adjusted HbA1c levels.

Methods
A single-center retrospective study was conducted, including children who were diagnosed with T1DM, were positive for at least one autoantibody, and were followed up for one year in our clinic between 2010 and 2020.

Results
Sixty-eight patients (55.9% female, 64.7% prepubertal) were included in the study, whose mean age was 8.4 ± 4.2 years. A total of 38 patients (55.9%) had partial clinical remission. None of the initial hematological indices were associated with the occurrence of partial remission. Initial neutrophil/lymphocyte ratio (NLR) and derived-NLR (d-NLR) levels were significantly lower (p=0.011 and 0.033, respectively) and lymphocyte/monocyte ratio (LMR) levels were significantly higher (p=0.005) in patients who showed an insulin requirement of <0.5 IU/kg/day at the 3rd month after diagnosis.

Conclusions
Initial hematological parameters were not found as a predictor of partial clinical remission period in T1DM in children. However, a lower NLR and d-NLR, or a higher LMR at the time of diagnosis can be used as an indicator of a low daily insulin need at the 3rd month of T1DM.
Calculation of the higher order eigenvalues for a homogeneous sphere using the FN
method
Authors: Yíldíz C. 
Published: March 2022

Abstract
The transport of monoenergetic neutrons in spherical geometry with forward scattering and vacuum boundary conditions is considered. The scaled transport equation is solved using the Fn method by considering the pseudo-slab problem. Numerical results for the fundamental and higher order eigenvalues are presented for several significant figures. Some selected results are compared with those obtained using various methods in the literature. Finally, a few remarks about the behavior of the criticality eigenvalue of the neutron transport equation with forward scattering is given.
Study of the possibility of high accuracy flow measurements with the pulsed neutron activation method
Authors: Nordlund A. , Avdic S. , Kaiser N. 
Published: March 2022

Abstract
The performance of water flow measurements with pulsed neutron activation (PNA) have been investigated in the past few years. In this report the following particular Problems were investigated: (a) the effect of collimation on the time-resolved detector signals; (b) the behavior of the background signal, in order to expedite optimum background elimination from the measured signals; and (c) the properties of water mixing, by measuring the geometrical asymmetry of the activated volume as a function of distance from the source as well as of flow velocity. It was seen that with the flow velocities and Reynolds numbers in the present experiments, the mixing is not perfect. Thus, in general, the PNA method will lead to an underestimation of the mass flow due to the effect of the laminar layer close to the wall whose contribution to the total mass flow will be enhanced. The investigations reported here contribute to the improvement of the accuracy of the method.
The astrophysical S-factor for dd-reactions at keV-energy range
Authors: Bystritskii V. , Bystritsky V. , Chaikovsky S. , Filipowicz M. , Grebenyuk V. , Gula E. , Makhrin V. , Mesyats G. , Parzhitski S. , Pen’kov F. , Ratakhin N. , Sinebryukhov V. , Sorokin S. , Stolupin V. , Volkov E. , Woźniak J. 
Published: March 2022

Abstract
The experimental results of measurements of the astrophysical S-factor for dd-reaction at keV-energy range collision energies using liner plasma technique are presented. The experiments were carried out at the high current generator of the Institute of High-Current Electronics in Tomsk, Russia. The measured values of the S-factors for the deuteron collision energies 1.80, 2.06 and 227 keV are

S

d
d

=
(
114
±
68
)
,
(
64
±
30
)
,
(
53
±
16
)
b
⋅
k
e
V
,

${{S}_{dd}}=(114\pm 68),(64\pm 30),(53\pm 16)b\cdot keV,$

respectively. The corresponding cross sections for dd-reactions, described as a product of the barrier factor and measured astrophysical S-factor, are

σ

d
d

n

(

E

c
o
l

=
1.80
keV

)

=
(
4.3
±
2.6
)
.

$\sigma _{dd}^{n}\left( {{E}_{col}}=1.80\text{keV} \right)=(4.3\pm 2.6).$

10

−
33

c

m
2

;

σ

d
d

n

(

E

c
o
l

=
2.06
keV

)

=
(
9.8
±
4.6
)
⋅

10

−
33

c

m
2

;

σ

d
d

n

(

E

c
o
l

=

${{10}^{-33}}~c{{m}^{2}};\sigma _{dd}^{n}\left( {{E}_{col}}=2.06\text{keV} \right)=(9.8\pm 4.6)\cdot {{10}^{-33}}~c{{m}^{\text{2}}};\sigma _{dd}^{n}\left( {{E}_{col}}= \right.$
An energy amplifier fluidized bed nuclear reactor concept
Authors: Sefidvash F. , Seifritz W. 
Published: March 2022

AbstractThe concept of a fluidized bed nuclear reactor driven by an energy amplifier system is described. The reactor has promising characteristics of inherent safety and passive cooling. The reactor can easily operate with any desired spectrum in order to be a plutonium burner or have it operate with thorium fuel cycle.
Fission product isotope ratios as event characterization tools– Part II: Radioxenon isotopic activity ratios
Authors: Finkelstein Y. 
Published: March 2022

AbstractAir sampling for radioxenon has been recommended as part of the verification system for a Comprehensive Nuclear-Test-Ban Treaty. Xenon isotopic activity ratios are used as a basis for confirming nuclear detonation, and discriminating between nuclear reactor accidental release and nuclear explosion. The primary purpose of this work is to use the available data on explosions, accidental reactor releases and laboratory experiments and simulations, in order to define the most probable scenarios for nuclear reactor accidental release, and for emission from underground nuclear detonations, to calculate the relevant radioxenon isotopic activity ratios in each scenario and to assess their use as event characterizing tools.
An accelerator–driven nuclear reactor
Authors: Shelaev L.A. , Baldin A. M. , Malakhov A. I. , Langrock E.–J. 
Published: March 2022

AbstractThe basic parameters of the accelerator facility for a proton beam of 100 mA and 1 GeV using a superconducting separate orbit cyclotron, are given. By means of such an accelerator system one can activate a subcritical 3 GW thermal power nuclear reactor of the well known RMBK–type 1000. The system is stable against any “Chernobyl–type” power excursion. When this accelerator system will be coupled to existing RMBK–type 1000 power stations, the resulting electricity production would become substantially more safe. Associated problems and design parameters are discussed.
High-energy neutron transport file for the 209Bi isotope
Authors: Pereslavtsev P. E. 
Published: March 2022

Abstract
The simulation of the nuclear processes, occurring in media irradiated with high-energy particles, promote the elaboration of high-energy transport files. These files being used in versatile computer codes, such as MCNP, allow to simulate with high accuracy particle transport. High-energy transport files are very important for the investigation of accelerator-driven systems. The detailed description of the methods and codes used for the elaboration of the file for 209 Bi is presented in this paper.
Radiological basis for the determination of exemption levels
Authors: Dymke N. 
Published: March 2022

Abstract
The Radiation Protection Ordinance implements a recommendation developed by the International Commission on Radiological Protection on terms of granting a practice to be carried out without reporting and prior authorisation, i. e. on conditions of exemption of justified practices from regulatory control. According to this recommendation, a practice may be exempted from regulatory control, if the radiological risk associated with the practice is, under normal conditions as well as in diverging situations, sufficiently low as not to warrant regulatory concern, and there are no reasonable control procedures that can achieve a significant reduction of the radiological risk. This article deals with the radiological criteria for the derivation of exemption values below which regulatory procedures are unwarranted, and goes into further subjects (design approval, consumer goods) for which the concept of exemption is applicable.
Derivation of the maximum permissible activity concentrations in waste water
Authors: Obrikat D. 
Published: March 2022

Abstract
In the present article, the formulas for calculation and the parameters and scenarios applied in the recalculation of the permitted activity concentrations for waste water from areas subject to radiation protection controls at the sites of those applying isotopes, performed on the basis of the amended version of the Radiation Protection Ordinance and Council Directive 96/29/Euratom, are discussed. The concentration values calculated for approximately 800 radionuclides are compiled in Table 4 in Appendix VII of the 2001 version of the Radiation Protection Ordinance. Modifications have been made by comparison with the values from the old version of the ordinance, due to the new dose coefficients and indications for dietary habits applied.
3D numerical investigation of natural circulation between the reactor pressure vessel and the cooling pond of a VVER-440 type reactor in incidental conditions during maintenance
Authors: Légrádi G. , Aszódi A. 
Published: March 2022

Abstract
During the annual maintenance of the VVER-440 type reactors, the reactor pressure vessel, the cooling pond and the transfer pond form a connected flow domain. The reactor is cooled by the natural circulation, which develops in one or two main loops. The cooling pond has its own cooling loops. CFD calculations have been performed with the code CFX-4.3 to investigate whether it is possible to cool the reactor core in case the main loops are lost and other emergency systems are not available. The results point out that the cooling system of the cooling pond is not capable of cooling the reactor core with the present connection. Therefore, modifications of the cooling system are investigated which would make it suitable for removing the remanent heat from the core.
Experimental and numerical investigation of sub-cooled boiling, condensation, and void flashing in nuclear heating reactor test loop
Authors: Yang X. , Jiang S. Y. , Zhang Y. 
Published: March 2022

Abstract
This paper describes experimental and numerical investigations of sub-cooled boiling, condensation, and void flashing in the HRTL-5 test loop, which simulates the primary loop of a 5 MW nuclear heating reactor. A drift-flow model of two-phase with four governing equations was used, in which sub-cooled boiling, condensation, and void flashing have been taken into account. Based on the mathematical model, a program has been developed for analyzing the natural circulation system. As parameters, inlet sub-cooling, system pressure, and heat flux are varied. For comparison, some simplified models, which are designed to reveal the importance of sub-cooled boiling, condensation, flashing in the HRTL-5 test loop, are adopted in the program. The results show: (1) sub-cooled boiling, condensation, and void flashing may have great influence on the distribution of the void fraction and more intense at low system pressure; (2) the calculation of them is correlative and interactive other than independent; (3) for a system with short heated section, long riser, and low pressure, it is possible to reach “boiling out of the core”, where there is almost no void in the heated section, but much in the riser.
Simulation of the gamma dose rate in a loss of pool water accident of the second Egyptian research reactor ET-RR-2
Authors: Amin E. , Saleh H. G. , Ashoub N. 
Published: March 2022

Abstract
The second Egyptian research reactor ET-RR-2, is a pool type reactor. A sudden loss of pool water would leave the core region uncovered. The reactor core is surrounded by chimney chambers with water isolated from the pool water. This accident would lead to significant external doses. A model is developed and used to calculate the dose rates for key access-areas and traffic plans from indirect line of sight of the core which have a maximum dose rate. The model developed uses the discrete ordinate method as implemented in the code DOT3.5.
Charge fragmentation in cosmic radiation – and the question of physical anomalons
Authors: Dutta A. , Batra V. , Biswas S. , Brandt R. 
Published: March 2022

Abstract

Data analysis is carried out for four detector stacks composed of passive Lexan polycarbonate detectors exposed in space by the Ultra Heavy Cosmic Ray Experiment on board NASA’s Long Duration Exposure Facility. Scanning and analysis of the 0.21 m2 detector area resulted in the finding of 72 ultra heavy (68 ≤ Z ≤ 96) cosmic ray nuclei. About 15% of the cosmic ray nuclei show charge fragmentation within the detector stack of 5.6 g × cm–2. A detailed analysis of these fragmented cosmic ray nuclei is presented, including a discussion within the context of “physical anomalons”. This last term, describing a sub-set of all anomalon phenomena, is defined in the text.
First record of a giant muntjac Muntiacus vuquangensis (Cervidae) from Cambodia
Authors: Pin Chanratana , Kamler Jan F. , Toem Yean , Lay Darith , Vorn Kongkea , Kim Nong , Macdonald David W. 
Published: March 2022

Abstract
The giant muntjac Muntiacus vuquangensis is a Critically Endangered ungulate that was first described by science in the early 1990s. The species’ current known distribution extends along the Annamite Mountains in Laos and Vietnam. Here, we report the first confirmed record of the giant muntjac in Cambodia. We recorded a camera-trap photograph of a male giant muntjac in Virachey National Park in northeastern Cambodia. Our record likely represents an isolated population near the western edge of the species’ distribution, about 300 km from the closest confirmed populations.
Patterns of genetic variation on wild pig (Sus scrofa) populations over a complete range of the species in Argentina
Authors: Figueroa Carlos Ezequiel , Acosta Diana Belén , Mac Allister Matias Exequiel , Merele Matías , Fernández Gabriela Paula , Carpinetti Bruno Nicolás , Winter Marina , Abate Sergio , Barandiaran Soledad , Merino Mariano Lisandro 
Published: March 2022

Abstract
In Argentina, wild pigs (Sus scrofa) are represented by wild boars and feral pigs. These populations inhabit a wide territory due to natural dispersion and human translocation. Previous studies in other countries have detected crossbreeding between the different morphotypes, even with domestic pigs. This crossing can lead to introgression of improved traits in the wild population, which would increase the invasive potential and, therefore, the damage to native ecosystems. The aim of this work was to obtain the patterns of genetic variability throughout its current distribution in Argentina, in order to elucidate genetic relationships between wild boar and feral pig populations through the molecular marker control region. For this purpose, studies of genetic variability and population structure were carried out using 377 sequences from Argentinian wild pigs. The high values of haplotype and nucleotide diversity (Hd = 0.866 and π = 0.00959) obtained, and the cluster analyses (SAMOVA and BAPS) could indicate mixing between wild pigs and/or with domestic pigs. The star-like shapes observed in the haplotype network and neutral tests (Fu’s Fs and Tajima’s D) are consistent with a recent population expansion, supporting previous reports that indicate crossbreeding increases invasive potential.
miR-22-5p regulates the self-renewal of spermatogonial stem cells by targeting EZH2
Authors: Lv Wenqiang , Yu Mei , Su Yilin 
Published: March 2022

Abstract
MiRNAs play an important role in spermatogonial stem cells (SSCs). The purpose of this study was to investigate the basic function of miR-22-5p in cryptorchidism. The results of RT-PCR, western blot, and immunohistochemistry showed that miR-22-5p was increased while EZH2 decreased in the testicular tissues of patients with cryptorchidism. Overexpression of miR-22-5p inhibited the proliferation of SSCs, increased cell apoptosis rate, and reduced expression of SSC marker proteins (GDNF and DAZL); however, knockout of miR-22-5p has the opposite effect. The Luciferase reporter gene assays demonstrated that EZH2 is a direct target of miR-22-5p. Moreover, EZH2 overexpression could reverse the effect of miR-22-5p mimic on SSCs’ proliferation, apoptosis, and expression of SSC marker proteins. Our results demonstrated that miR-22-5p regulates SSCs’ self-renewal by targeting EZH2, which indicated that miR-22-5p may serve as a biological marker for the treatment of infertility caused by cryptorchidism.
circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8
Authors: Wei Wei , Wang Changyong , Wang Lele , Zhang Jianfeng 
Published: March 2022

Abstract
High circ_0020123 expression is associated with poor prognosis in patients with non-small cell lung cancer (NSCLC) as previously reported. Whether circ_0020123 also plays an oncogenic role in lung adenocarcinoma (LUAD) is still unknown. Additionally, circ_0020123 is derived from part of exon (1312–3851) from its host gene PDZ domain-containing protein 8 (PDZD8). We hypothesized that circ_0020123 might affect malignant behaviors of LUAD cells by regulating PDZD8. Reverse transcription quantitative polymerase chain reaction revealed that PDZD8 was highly expressed in LUAD tissues and cells. PDZD8 knockdown suppressed LUAD cell proliferation and migration as shown by colony formation assays, Ethynyl deoxyuridine incorporation assays, Transwell assays, and wound healing assays. circ_0020123 was also found to be upregulated in LUAD tissues and cells. Moreover, circ_0020123 positively regulated PDZD8 expression in LUAD cells but exerted no significant effect on the transcriptional level of PDZD8. Mechanistically, circ_0020123 act as a competing endogenous RNA (ceRNA) to interact with miR-1283, thereby releasing the repression on PDZD8. Moreover, PDZD8 overexpression rescued the suppressive effect of circ_0020123 knockdown on LUAD cell proliferation and migration. In conclusion, circ_0020123 interacts with miR-1283 as a ceRNA to regulate PDZD8 expression, thus promoting the proliferation and migration of LUAD cells. The study might provide new biomarkers for future LUAD investigation.
Integrated ultra-high-performance graphene optical modulator
Authors: Heidari Elham , Dalir Hamed , Koushyar Farzad Mokhtari , Nouri Behrouz Movahhed , Patil Chandraman , Miscuglio Mario , Akinwande Deji , Sorger Volker J. 
Published: March 2022

Abstract
With the increasing need for large volumes of data processing, transport, and storage, optimizing the trade-off between high-speed and energy consumption in today’s optoelectronic devices is getting increasingly difficult. Heterogeneous material integration into silicon- and nitride-based photonics has showed high-speed promise, albeit at the expense of millimeter-to centimeter-scale footprints. The hunt for an electro-optic modulator that combines high speed, energy efficiency, and compactness to support high component density on-chip continues. Using a double-layer graphene optical modulator integrated on a Silicon photonics platform, we are able to achieve 60 GHz speed (3 dB roll-off), micrometer compactness, and efficiency of 2.25 fJ/bit in this paper. The electro-optic response is boosted further by a vertical distributed-Bragg-reflector cavity, which reduces the driving voltage by about 40 times while maintaining a sufficient modulation depth (5.2 dB/V). Modulators that are small, efficient, and quick allow high photonic chip density and performance, which is critical for signal processing, sensor platforms, and analog- and neuromorphic photonic processors.
Crystal structure of catena-poly[(μ2-1,1′-(biphenyl-4,4′-diyl)bis(1H-imidazol)-κ2
N:N′)-bis(4-bromobenzoate-κ1
O)cobalt(II)], C32H22Br2CoN4O4
Authors: Zhuo Xin 
Published: March 2022

Abstract
C32H22Br2CoN4O4, monoclinic, P21/c (no. 4), a = 6.5529(11) Å, b = 24.375(4) Å, c = 18.379(3) Å, β = 97.491(3)°, V = 2910.6(8) Å3, Z = 4, R

gt
(F) = 0.0404, wR

ref
(F
2) = 0.1268, T = 296(2) K.
Disinfecting activity of some diphenyltin(IV) benzoate derivative compounds
Authors: Hadi Sutopo , Suhartati Tati , Noviany Noviany , Pandiangan Kamisah D. , Yandri Yandri , Simanjuntak Wasinton , Junaidi Junaidi 
Published: March 2022

Abstract
Disinfecting activity test of four diphenyltin(IV) benzoate derivative compounds has been carried out. The four compounds investigated were diphenyltin (IV) di 4 aminobenzoate (DPDA) (2), diphenyltin (IV) di 4 chlorobenzoate (DPDC) (3), diphenyltin(IV) di-4-hydroxybenzoate (DPDH) (4), and diphenyltin(IV) di-4-nitrobenzoate (DPDN) (5), and they were prepared by reacting diphenyltin(IV) oxide (DPO) (1) with benzoic acid derivatives of 4-aminobenzoic acid (4-HABz), 4-chlorobenzoic acid (4-HCBz), 4-hydroxybenzoic acid (4-HHBz) and 4-nitrobenzoic acid (4-HNBz), respectively. The compounds were well characterized by 1H, 13C NMR, IR, UV spectroscopies, and their pieces were defined using microanalytical data. The disinfectant test was carried out on two bacteria, Gram-negative Salmonella sp., and Gram-positive Staphylococus aureus. The result showed that all of the compounds were active as a disinfectant (disinfecting agent) with a minimum inhibitory concentration of 5 × 10−4 M. Compound 5 was found to be most active compared to others which exhibited the ability to reduce the concentration of the S. aureus bacteria within 5 min.