bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sugarcane mild mosaic virus: The rediscovery of an identified but unrecognized virus
Authors: Mollov Dimitre , Filloux Denis , Grinstead Samuel , Bolus Stephen , Claude Lisa , Fernandez Emanuel , Julian Charlotte , Candresse Thierry , Lockhart Ben , Roumagnac Philippe , Rott Philippe , Daugrois Jean Heinrich 
Published: October 2022

AbstractThe complete genome sequence of a previously uncharacterized sugarcane‐infecting virus of the genusAmpeloviruswas obtained by high‐throughput sequencing (HTS) and rapid amplification of cDNA ends. This genome consists of 13,114 nucleotides (nt) and harbours seven open reading frames. Phylogenetic and pairwise identity analyses with the complete or near‐complete genome sequences of 16 isolates revealed that they all belong to a newAmpelovirusspecies, familyClosteroviridae. These 16 isolates were distributed in three phylogenetic groups and potential recombinant events were identified for only one of these isolates. An immunocapture‐reverse transcription‐PCR (IC‐RT‐PCR) assay was developed with antibodies previously produced against a clostero‐like virus that had not yet been recognized by the International Committee on Taxonomy of Viruses but for which the name sugarcane mild mosaic virus (SCMMV) had been proposed. The new ampelovirus was detected by IC‐RT‐PCR, and Sanger‐sequenced amplicons confirmed the identity of the virus based on HTS data. SCMMV was detected in 65 of 350 samples of quarantined sugarcane germplasm using RT‐PCR targeting thehsp70gene. These samples originated from Africa, the Caribbean, North America, South America and South‐east Asia, thus revealing that SCMMV is present in many sugarcane‐growing regions of the world. The complete or near‐complete sequences reported here represent the first genomic sequences for SCMMV. Furthermore, the newly developed RT‐PCR diagnostic assay will facilitate the understanding of SCMMV epidemiology and will help improve management practices.
Microbial resistance to oral antiseptics used in hospitalized patients: A systematic scoping review of randomized clinical trials
Authors: Ardila Carlos‐M. , Bedoya‐García Jader Alexander 
Published: October 2022

AbstractAimsTo evaluate the prevalence and proportions of bacteria resistant to oral antiseptics used in hospitalized patients.Methods and resultsA review of randomized clinical trials (RCTs) was led by implementing the PRISMA extension for scoping reviews including various databases. MeSH terms and keywords were used to assess only RCTs with antiseptic‐resistant outcomes. Fourth RCTs met the selection criteria. These trials studied 399 hospitalized patients for respiratory infections or cardiovascular disease. Methicillin‐resistant Staphylococcus aureus and Acinetobacter baumannii were predominant pathogens in the chlorhexidine group. It was found that Veillonella parvula and Campylobacter gracilis (57% of the isolates) had resistance to triclosan, while 67% of Pseudomonas, Acinetobacter, and Enterobacter species presented resistance to chlorhexidine. However, an increase in minimal inhibitory concentrations of triclosan or chlorhexidine during the follow‐up period was not observed. Moreover, chlorhexidine reduced the amount of S. aureus in dental plaque and the oropharyngeal colonization by aerobic microorganisms; nonetheless, it was unsatisfactory to decrease the occurrence of respiratory infections. No adverse events were reported.ConclusionsResistance of V. parvula and C. gracilis to triclosan, and Pseudomonas, Acinetobacter, and Enterobacter species to chlorhexidine were perceived. However, these resistances did not increase during the follow‐up period.
Digital skin imaging applications, part II: a comprehensive survey of post‐acquisition image utilization features and technology standards
Authors: Sun Mary D. , Kentley Jonathan , Wilson Britney W. , Soyer H. Peter , Curiel‐Lewandrowski Clara N. , Rotemberg Veronica M. , Halpern Allan C. ,   the ISIC Technique Working Group
Published: October 2022

AbstractBackgroundDespite the increasing ubiquity and accessibility of teledermatology applications, few studies have comprehensively surveyed their features and technical standards. Importantly, features implemented after the point of capture are often intended to augment image utilization, while technical standards affect interoperability with existing healthcare systems. We aim to comprehensively survey image utilization features and technical characteristics found within publicly discoverable digital skin imaging applications.Materials and MethodsApplications were identified and categorized as described in Part I. Included applications were then further assessed by three independent reviewers for post‐imaging content, tools, and functionality. Publicly available information was used to determine the presence or absence of relevant technology standards and/or data characteristics.ResultsA total of 20 post‐image acquisition features were identified across three general categories: (1) metadata attachment, (2) functional tools (i.e., those that utilized images or in‐app content to perform a user‐directed function), and (3) image processing. Over 80% of all applications implemented metadata features, with nearly half having metadata features only. Individual feature occurred and feature richness varied significantly by primary audience (p < 0.0001) and function (p < 0.0001). On average, each application included under three features. Less than half of all applications requested consent for user‐uploaded photos and fewer than 10% provided clear data use and privacy policies.ConclusionPost‐imaging functionality in skin imaging applications varies significantly by primary audience and intended function, though nearly all applications implemented metadata labeling. Technical standards are often not implemented or reported consistently. Gaps in the provision of clear consent, data privacy, and data use policies should be urgently addressed.
Indicators of soil quality and crop productivity assessment at a long‐term experiment site in the lowerIndo‐Gangeticplains
Authors: Ghorai Partha Sarathi , Biswas Sunanda , Purakayastha Tapan Jyoti , Ahmed Nayan , Das Tapas Kumar , Prasanna Radha , Gawade Bharat Hanamant , Bhattacharyya Kallol , Sinha Kanchan , Singh Priya , Das Sujit 
Published: October 2022

AbstractDeterioration of soil quality under resource‐intensive modern agriculture in the face of global climate change poses a huge risk to food security. Because of the complex nature, estimators of soil quality often rely upon a limited set of soil attributes, along with statistical data reduction techniques, for developing quality indices, whilst overlooking biological aspects and regional climatic variability. This study screened the most suitable soil quality indexing approaches for a rice‐oilseed‐based cropping system in the lower Indo‐Gangetic plains (IGP). For this, surface soil samples (0–15 cm) were collected from an ongoing long‐term fertilizer experiment with a rice‐mustard‐sesame cropping system in the IGP. The following treatments were assessed for their effect on soil quality:T1‐control,T2‐NPK (recommended NPK doses),T3‐NPKG (NPK + in situ green manuring),T4‐NPKGB (NPK + in situ green manuring + biofertilizer) andT5‐NPKF (NPK + farm yard manure FYM). We found that total organic carbon (TOC),β‐glucosidase, CaCl2extractable S, alkaline KMnO4oxidizable N, activity of urease, amidase enzyme and mean weight diameter (MWD) were sensitive key indicators of soil quality. The NPKF treatment maintained the highest soil quality status (0.80–0.91), both under productivity and environmental protection goals, owing to the availability of decomposable carbon. Regression analysis showed a better agreement of equivalent rice yield with expert opinion (EO;R2 = 0.89) than principal component analysis (PCA;R2 = 0.76). Finally, we found that the expert opinion approach with the nonlinear scoring function was the best tool for soil quality assessment of the region.
Investigating COVID‐19 transmission in a tertiary hospital in Hanoi, Vietnam using social network analysis
Authors: Hoang Ngoc‐Anh Thi , Pham Thai Quang , Quach Ha‐Linh , Hoang Ngoc Van , Nguyen Khanh Cong , Dang Duc‐Anh , Vogt Florian 
Published: October 2022

AbstractObjectivesIn March 2020, a COVID‐19 outbreak in a major referral hospital in Hanoi, Vietnam led to 7664 patients and staff being sent into lockdown for 2 weeks, and more than 52,200 persons across 49 provinces being quarantined. We assessed SARS‐CoV‐2 transmission patterns during this to‐date largest hospital outbreak in Vietnam using social network analysis (SNA).MethodsWe constructed a directed relational network and calculated network metrics for ‘degree’, ‘betweenness’, ‘closeness’ and ‘eigenvector’ centrality to understand individual‐level transmission patterns. We analysed network components and modularity to identify sub‐network structures with disproportionately big effects.ResultsWe detected 68 connections between 46 confirmed cases, of whom 27 (58.7%) were ancillary support staff, 7 (15.2%) caregivers, 6 (13%) patients and 2 (4.4%) nurses. Among the 10 most important cases selected by each SNA network metric, transmission dynamics clustered in 17 cases, of whom 12 (70.6%) cases were ancillary support staff. Ancillary support staff also constituted 71.1% of cases in the dominant sub‐network and 68.8% of cases in the three largest sub‐communities.ConclusionsWe identified non‐clinical ancillary support staff, who are responsible for room service and food distribution in hospital wards in Vietnam, as a group with disproportionally big impacts on transmission dynamics during this outbreak. Our findings call for a holistic approach to nosocomial outbreak prevention and response that includes both clinical and non‐clinical hospital staff. Our work also shows the potential of SNA as a complementary outbreak investigation method to better understand infection patterns in hospitals and similar settings.
HCN1 channels mediate mu opioid receptor long‐term depression at insular cortex inputs to the dorsal striatum
Authors: Munoz Braulio , Fritz Brandon M. , Yin Fuqin , Atwood Brady K. 
Published: October 2022

AbstractMu opioid receptors (MORs) are expressed in the dorsal striatum, a brain region that mediates goal‐directed (via the dorsomedial striatum) and habitual (via the dorsolateral striatum, DLS) behaviours. Our previous work indicates that glutamate transmission is depressed when MORs are activated in the dorsal striatum, inducing MOR‐mediated long‐term synaptic depression (MOR‐LTD) or short‐term depression (MOR‐STD), depending on the input. In the DLS, MOR‐LTD is produced by MORs on anterior insular cortex (AIC) inputs and MOR‐STD occurs at thalamic inputs, suggesting input‐specific MOR plasticity mechanisms. Here, we evaluated the mechanisms of induction of MOR‐LTD and MOR‐STD in the DLS using pharmacology and optogenetics combined with patch‐clamp electrophysiology. We found that cAMP/PKA signalling and protein synthesis are necessary for MOR‐LTD expression, similar to previous studies of cannabinoid‐mediated LTD in DLS. MOR‐STD does not utilize these same mechanisms. We also demonstrated that cannabinoid‐LTD occurs at AIC inputs to DLS. However, while cannabinoid‐LTD requires mTOR signalling in DLS, MOR‐LTD does not. We characterized the role of presynaptic HCN1 channels in MOR‐LTD induction as HCN1 channels expressed in AIC are necessary for MOR‐LTD expression in the DLS. These results suggest a mechanism in which MOR activation requires HCN1 to induce MOR‐LTD, suggesting a new target for pharmacological modulation of synaptic plasticity, providing new opportunities to develop novel drugs to treat alcohol and opioid use disorders.
imageKey points
Mu opioid receptor‐mediated long‐term depression at anterior insular cortex inputs to dorsolateral striatum involves presynaptic cAMP/PKA signalling and protein translation, similar to known mechanisms of cannabinoid long‐term depression.
Dorsal striatal cannabinoid long‐term depression also occurs at anterior insular cortex inputs to the dorsolateral striatum. Dorsal striatal cannabinoid long‐term depression requires mTOR signalling, similar to hippocampal cannabinoid long‐term depression, but dorsal striatal mu opioid long‐term depression does not require mTOR signalling.
Mu opioid long‐term depression requires presynaptic HCN1 channels at anterior insular cortex inputs to dorsolateral striatum.
More on boundary conditions for warped AdS$$_3$$ in GMG
Authors: Sajadi Seyed Naseh , Hajilou Ali 
Published: October 2022

AbstractIn this paper, we study the Aggarwal, Ciambelli, Detournay, and Somerhausen (ACDS) boundary conditions (Aggarwal et al. in JHEP 22:013, 2020) for Warped AdS$$_3$$

3

(WAdS$$_3$$

3

) in the framework of General Massive Gravity (GMG) in the quadratic ensemble. We construct the phase space, the asymptotic structure, and the asymptotic symmetry algebra. We show that the global surface charges are finite, but not integrable, and also we find the conditions to make them integrable. In addition, to confirm that the phase space has the same symmetries as that of a Warped Conformal Field Theory (WCFT), we compare the bulk entropy of Warped BTZ (WBTZ) black holes with the number of states belonging to a WCFT.
Life of the homogeneous and isotropic universe in dynamical string tension theories
Authors: Guendelman E. I. 
Published: October 2022

AbstractCosmological solutions are studied in the context of the modified measure formulation of string theory , then the string tension is a dynamical variable and the string the tension is an additional dynamical degree of freedom and its value is dynamically generated. These tensions are then not universal, rather each string generates its own tension which can have a different value for each of the string world sheets and in an ensemble of strings. The values of the tensions can have a certain dispersion in the ensemble. We consider a new background field that can couple to these strings, the “tension scalar” which is capable of changing locally along the world sheet and then the value of the tension of the string changes accordingly. When many types of strings probing the same region of space are considered this tension scalar is constrained by the requirement of quantum conformal invariance. For the case of two types of strings probing the same region of space with different dynamically generated tensions, there are two different metrics, associated to the different strings. Each of these metrics have to satisfy vacuum Einstein’s equations and the consistency of these two Einstein’s equations determine the tension scalar. The universal metric, common to both strings generically does not satisfy Einstein’s equation . The two string dependent metrics considered here are flat space in Minkowski space and Minkowski space after a special conformal transformation. The limit where the two string tensions are the same is studied, it leads to a well defined solution. If the string tension difference between the two types of strings is very small but finite, the approximately homogeneous and isotropic cosmological solution lasts for a long time, inversely proportional to the string tension difference and then the homogeneity and and isotropy of the cosmological disappears and the solution turns into an expanding braneworld where the strings are confined between two expanding bubbles separated by a very small distance at large times. The same principle is applied to the static end of the universe wall solution that lasts a time inversely proportional to the dispersion of string tensions. This suggest a scenario where quantum fluctuations of the cosmological or static solutions induce the evolution towards braneworld scenarios and decoherence between the different string tension states.
Probing a black-bounce-Reissner–Nordström spacetime with precessing and periodic motion
Authors: Zhang Jing , Xie Yi 
Published: October 2022

AbstractWe investigate the precessing and periodic orbits of a test timelike particle around the black-bounce-Reissner–Nordström spacetime which is characterized by its charge and bounce parameter. Its marginally bound orbit and innermost stable circular orbit are obtained in the exact forms. We pay closely attention to its precessing orbits and find the resulting relativistic periastron advance. We also study its periodic orbits and demonstrate that small variations of the charge and bounce parameter can make the motion jump among the periodic and precessing orbits. In these two kinds of orbits, we find a distinct degeneracy that some specific combinations of the charge and bounce parameters can generate exactly the same orbital motion in the black-bounce-Reissner–Nordström spacetime, which can also mimic those of the Schwarzschild black hole. In order to break such a degeneracy, we make use of the precession of S2 star around Sgr A* detected by GRAVITY together with the shadow diameter of Sgr A* measured by Event Horizon Telescope and find preliminary bounds on the charge and bounce parameter.
Effect of Risk-Focused Diversified Safety Management Mode in Patients with Major Artery Stent Implantation
Authors: Shao Yan , Wu Cai-Juan , Mao Youjun , Li Dong-Mei , Wang Yun-Zhou , Zhu Kang 
Published: October 2022

Background. Intracranial atherosclerotic stenosis (ICAS) causes a series of neurological symptoms, such as vertigo, impaired consciousness, limb weakness, ataxia, dysphagia, ocular motility disorders, and visual impairment. With the improvement of people’s living standards, there are higher requirements for nursing care. Nursing, as an indispensable part of medical care, is closely related to achieving the goal of patient’s safety and the overall quality of nurses, quality of care, and nursing management methods. Objective. To explore the effect of risk-centered diversified safety management in patients undergoing aortic stenting. Methods. Eighty patients with cerebral infarction were selected and treated with percutaneous transluminal angioplasty and stent implantation (PTAS). Then they were divided into a control group (40 cases) with routine monitoring and an experimental group (40 cases) with risk-focused intervention of a diversified safety management model according to the mode of care. Patient satisfaction and blood index test results were compared after the intervention. Results. Patients in the experimental group had 6 falls, 3 bed falls, 3 phlebitis, 4 tube slips, and 10 deep vein thrombosis, all significantly fewer than those in the control group. Thirty-eight patients in the experimental group expressed satisfaction with safe management, which was substantially better than the control group (

P
<
0.05

). The levels of tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PA1-1), and von Willebrand factor (vWF) in the experimental group were (13.5

±

1.3) ng/mL, (60.1

±

9.9) ng/mL, and (2.1

±

0.2), respectively, which were substantially lower than those in the control group ((14.6

±

2.4) ng/mL, (64.2

±

10.7) ng/mL, and (2.8

±

0.3)), respectively (

P
<
0.05

). Conclusion. The risk-centered diversified safety management model can effectively reduce the probability of adverse events in patients, improve patient satisfaction with nursing services, and promote faster postoperative recovery, which has clinical application value.
Application of Nursing Outcome-Oriented Integrated Zero-Defect Nursing Combined with Respiratory Function Training in Long-Term Bedridden Patients Undergoing Stroke
Authors: Xu Shaona , Yu Yanan , Liu Hongling , Qiu Weiwei , Tang Yu , Liu Ying 
Published: October 2022

Objective. To explore the application effect of nursing outcome-oriented integrated zero-defect nursing combined with respiratory function training in long-term bedridden patients with stroke. Methods. A total of 120 long-term bedridden patients with stroke were randomly divided into three groups: groups A, B, and C. Group A was given nursing outcome-oriented integrated zero-defect nursing combined with respiratory function training, group B was given nursing outcome-oriented integrated zero-defect nursing, and group C was given routine nursing. Rosenbek aspiration degree classification criteria were used to evaluate the incidence of aspiration; blood oxygen saturation, arterial oxygen partial pressure, and respiratory pressure were compared before and after the intervention. The swallowing function was evaluated by a water swallowing test (WST). The quality of life was assessed using the Generic Quality of Life Inventory-74 (GQOLI-74). Results. After treatment, the Rosenbek aspiration degree of groups A and B were better than those of group C (

P

< 0.05); the improvement degree of respiratory function indexes in group A was better than those in B and C, and the blood oxygen saturation and arterial blood oxygen partial pressure in group B were better than those in C (

P

< 0.05). The incidence of complications in groups A and B was lower than that in C, and complications in group A were lower than that in B (

P

< 0.05). After treatment, the scores of psychological function, social function, and material life status of the three groups were increased, and each score of groups A and B was higher than that of C, and each score of group A was higher than that of B (

P

< 0.05). Conclusion. Nursing outcome-oriented integrated zero-defect nursing combined with respiratory function training can effectively improve aspiration, respiratory function, swallowing function, complication rate, and quality of life in long-term bedridden patients with stroke.
Colour, location and movement: what do models tell us about predation on colour morphs of a poison frog from eastern Amazonia?
Authors: da Rocha Sulamita M.C. , Magnusson William E. , Rojas Diana , Lima Albertina P. 
Published: October 2022

Abstract
Many dendrobatid frogs are known to be aposematic: brightly coloured and unpalatable to predators. To deceive predators, frog models used to test for predatory colour bias must be similar in size, colour, shape, and movement to frogs. We carried out an experiment with moving models of the species Adelphobates galactonotus, in two localities. A. galactonotus is a polytypic frog and each population of the species has a distinct colour. Birds and mammals were the vertebrates responsible for the marks on the models, but there was no difference in frequency of attacks on local-, non-local- and cryptic-colour models. Only invertebrates avoided cryptic models. Different populations of the species seem to be under different predation pressure, but colour differentiation in this species is probably related to other mechanisms, such as sexual selection.
From Diyārāt to Ziyārāt
Authors: Sajdi Dana 
Published: October 2022

Abstract
This essay explores the relationship between two geographical and literary genres, the diyārāt (Books of Monasteries), which disappeared in the 11th century, and the ziyārāt (shrine pilgrimage guides), which appeared in the 13th century. The relationship is discussed in the context of the transformation of the Syrian sacred landscape, which became thoroughly Islamized through the erection of Islamic public buildings including shrines and mausolea between the 11th–13th centuries. I argue that these two genres had a similar function of spatially inscribing the political order through the invitation to liminal practices in the marginal sites of the monastery and the Islamic shrine/mausoleum. The diyārāt registered the caliphal order and courtly culture, while the ziyārāt served to sanctify the professional scholar whose authority emerged in the post-caliphal sultanic age.