bluuebunny/crossref_metadata_2025_split huggingface dataset:
REFLECTING THE ROLE OF LEISURE AND LEISURE PREFERENCES OF YOUTH IN MODERN SOCIETY
Authors: Mishina Tatyana V. 
Published: February 2022

Relevance: the transformations and integration processes taking place in the modern world are undoubtedly reflected in the leisure preferences of society, in the understanding of leisure itself, in the change in the socio-cultural situation in the sphere of leisure. Leisure for young people is one of the primary values, which gives them the opportunity to develop, realize, satisfy certain needs. Understanding of leisure, its role in the formation of personality and significance in society is a prerequisite for understanding the modern sociocultural situation.
Purpose and methods of research: to determine the meaningful characteristics of leisure and leisure preferences of young people in modern society. To achieve this goal, we carried out a theoretical analysis of literary sources, which allows us to define leisure as one of the key values of human life, to identify its meaningful elements. The empirical block of work is presented by sociological research, which allows to determine the understanding of “leisure” and leisure preferences of modern youth.
Results. The results obtained in the course of the study give us the opportunity to conclude that in the modern world there is a certain reassessment of the value of leisure as a philosophical and cultural category in the life of society. Leisure is changing its orientations, transforming from relaxation to the possibility of self-realization and self-development of one’s creative and intellectual potential.
Scope of the results. The results obtained in the course of the research can be taken into account and applied within the framework of educational work in educational institutions, as well as in cultural institutions for organizing relevant events and festive programs.
Robust Satisficing
Authors: Long Daniel Zhuoyu , Sim Melvyn , Zhou Minglong 
Published: February 2022

We present a general framework for robust satisficing that favors solutions for which a risk-aware objective function would best attain an acceptable target even when the actual probability distribution deviates from the empirical distribution. The satisficing decision maker specifies an acceptable target, or loss of optimality compared with the empirical optimization model, as a trade-off for the model’s ability to withstand greater uncertainty. We axiomatize the decision criterion associated with robust satisficing, termed as the fragility measure, and present its representation theorem. Focusing on Wasserstein distance measure, we present tractable robust satisficing models for risk-based linear optimization, combinatorial optimization, and linear optimization problems with recourse. Serendipitously, the insights to the approximation of the linear optimization problems with recourse also provide a recipe for approximating solutions for hard stochastic optimization problems without relatively complete recourse. We perform numerical studies on a portfolio optimization problem and a network lot-sizing problem. We show that the solutions to the robust satisficing models are more effective in improving the out-of-sample performance evaluated on a variety of metrics, hence alleviating the optimizer’s curse. Funding: D. Z. Long is supported by the Hong Kong Research Grants Council [Grant 14207819]. M. Sim and M. Zhou are supported by the Ministry of Education, Singapore, under its 2019 Academic Research Fund Tier 3 [Grant MOE-2019-T3-1-010]. Supplemental Material: The online appendices are available at https://doi.org/10.1287/opre.2021.2238 .
Psychometric Properties of Self-Determination Inventory: Student Report Among Chinese Students With and Without Intellectual and Developmental Disabilities
Authors: Xu Tianxi , Qian Xueqin , Rifenbark Graham G. , Shogren Karrie A. , Hagiwara Mayumi 
Published: February 2022

Abstract
This study explores the psychometric properties of Self-Determination Inventory: Student Report (SDI:SR) in students with intellectual and developmental disabilities (IDD) and without disabilities in China. The paper-and-pencil version of SDI:SR Chinese Translation (SDI:SR Chinese) was used to explore self-determination across students with IDD (n = 245) and students without disabilities (n = 315) from 16 schools across six cities in China. We examined the factor structure of the measure, conducted analysis of measurement invariance, and compared the latent means across students with IDD and without disabilities. Findings suggest that the data fit a one-factor model better than a three-factor model. We found greater variability in self-determination among students with IDD than students without disabilities. However, the two groups did not differ in latent means.
Agiles IT-Controlling
Authors: Albayrak Can Adam , Gadatsch Andreas , Haag Benedikt 
Published: February 2022

ZusammenfassungWährend im IT-Projektmanagement agile Methoden seit vielen Jahren in der Praxis Zuspruch finden, werden im IT-Controlling überwiegend noch klassische Methoden eingesetzt. Der Beitrag untersucht die Fragestellung, ob und wie die im IT-Controlling eingesetzten Methoden auch agilen Paradigmen folgen und Methoden des agilen IT-Projektmanagements adaptiert werden können.
Yme2, a putative RNA recognition motif and AAA+ domain containing protein, genetically interacts with the mitochondrial protein export machinery
Authors: Sharma Nupur , Osman Christof 
Published: February 2022

Abstract
The mitochondrial respiratory chain is composed of nuclear as well as mitochondrial-encoded subunits. A variety of factors mediate co-translational integration of mtDNA-encoded proteins into the inner membrane. In Saccharomyces cerevisiae, Mdm38 and Mba1 are ribosome acceptors that recruit the mitochondrial ribosome to the inner membrane, where the insertase Oxa1, facilitates membrane integration of client proteins. The protein Yme2 has previously been shown to be localized in the inner mitochondrial membrane and has been implicated in mitochondrial protein biogenesis, but its mode of action remains unclear. Here, we show that multiple copies of Yme2 assemble into a high molecular weight complex. Using a combination of bioinformatics and mutational analyses, we find that Yme2 possesses an RNA recognition motif (RRM), which faces the mitochondrial matrix and a AAA+ domain that is located in the intermembrane space. We further show that YME2 genetically interacts with MDM38, MBA1 and OXA1, which links the function of Yme2 to the mitochondrial protein biogenesis machinery.
High-temperature oxidation wear performance and mechanism of Cr–Mo (W)–V hot-work die steel
Authors: Shi Yuanji , Yu Linhui , Guo Xunzhong , Cheng Cheng , Zuo Pengpeng , Dai Yunzhong 
Published: February 2022

Abstract
Dry sliding tests for Cr–Mo (W)–V hot-work die steels were performed at 400–700 °C using a UMT-3 wear tester. The wear behavior was studied systematically to explore the general characteristics under high-temperature oxidation conditions. When a mild-to-severe oxidation wear transition occurred, the wear rate of the Cr–Mo (W)–V hot-work die steels could be divided into different stages. The wear rate in stage I remained low and increased continuously with increasing temperature in stage II. It decreased within a narrow temperature range in stage III and increased significantly at a high test temperature in stage IV. The microstructures of DM, H21, and H13 steels at 350 HV30 were observed in stage III, and the M
2C carbides were extensively analyzed. Furthermore, by examining the continuous heating transformation curves, the decrease in the wear rate in stage III was qualitatively confirmed, depending on the transformation of the M
2C carbides.
Large-scale timetabling problems with adaptive tabu search
Authors: Awad Fouad H. , Al-kubaisi Ali , Mahmood Maha 
Published: February 2022

AbstractTimetabling problems are specific types of scheduling problems that deal with assigning certain events to the timeslots. This assigning is subject to certain hard constraints that should be achieved to get a feasible timetable and soft constraints that must meet as many as possible during forming a feasible schedule. This paper introduces an adaptive tabu search. Eleven benchmark datasets of the year 2002 are applied to show the effectiveness of the introduced algorithm. These datasets consist of 5-small, 5-medium, and 1-large dataset. As compared to other methods from previous works, the proposed algorithm produces excellent timetables, in comparison with the algorithms as well as the current results, the mathematical results showed the high effectiveness of the suggested algorithm. It has a minor deficit on the medium or the small problem adaptive Tabu, and the tabu search relies on the tabu list and penalty cost when the change in the penalty cost is checked; if it is still unchanged for the period of iterations (1,000 iterations), the tabu list reduces automatically by (−2); furthermore, the tabu list remains constant.
River-based and egocentric spatial orientation in Yine
Authors: Robbers Maja 
Published: February 2022

AbstractIn linguistic studies on spatial reference frames, South American languages are still underrepresented. This explorative study offers a qualitative discussion of strategies that were found to encode location and orientation of objects in Yine, an Amazonian language of Peru. Geocentric and egocentric frames were attested as equally dominant strategies to provide spatial information in a picture-matching task, the results of which are split by age group of speakers. Senior Yine speakers mainly used river-oriented geocentric and intrinsic frames, whereas young adult speakers relied on egocentric and intrinsic frames exclusively. Left/right/behind relators were predominantly interpreted in allocentric-intrinsic frames by speakers of both groups but egocentric-extrinsic frames also arose in spatial descriptions elicited from younger speakers.
Conflation of spatial reference frames in deaf community sign languages
Authors: Tkachman Oksana 
Published: February 2022

AbstractLinguistic spatial descriptions are not purely arbitrary, but are to some extent motivated by many interactive factors. For example, whether the language community is predominantly urban or rural may motivate its reliance on relative or absolute reference frame (Dasen and Mishra 2010; Pederson 1993, 2006). This review paper contributes to Sociotopography in two ways: first, by showing that the distribution of reference frames reported in the literature corresponds to deaf community sign languages and village sign languages (thus the urban-rural differences generalize across modalities), and second, that deaf community sign languages all allow their users to employ a conflated intrinsic-relative frame, which is possibly due to affordances of the visual-manual modality (a modality-specific feature). Comparing the visual-manual and the aural-oral modalities therefore shows that some variation in spatial descriptions correlates with the environment regardless of the modality used, but also highlights modality-specific properties.
A quantitative approach to sociotopography in Austronesian languages
Authors: Pappas Leah , Holton Gary 
Published: February 2022

AbstractAbsolute spatial orientation systems are pervasive and diverse among Austronesian languages, and decades of research has suggested that such systems are motivated at least in part by environmental and cultural factors. In this paper, we take a quantitative approach to the study of orientation systems by presenting the results of an exploratory multifactorial analysis of spatial orientation systems across 131 Austronesian languages, representing nearly all available data on orientation systems for the family. We analyze these data using multinomial logistic regression to uncover correlations between orientation type and four predictor variables representing cultural and environmental factors: geographic distribution, economy, geography (proximity to the sea), and ruggedness of terrain. Our model suggests that while not entirely predictive of the type of orientation system, the factors geography and economy alone account for much of the variation among spatial orientation systems in our sample, supporting a “weak” form of the Sociotopographic Model (Palmer, Bill, Jonathon Lum, Jonathan Schlossberg & Alice Gaby. 2017. How does the environment shape spatial language? Evidence for sociotopography.Linguistic Typology21(3). 457–491). Additionally, this study demonstrates the potential of quantitative analytical methods for exploring the relationship between culture, environment, and spatial orientation systems.
Retrospective analysis of crescent score in clinical prognosis of IgA nephropathy
Authors: Chen Ying , Yang Yiya , Liang Yumei , Liu Manting , Xiao Wei , Hu Xiaofang 
Published: February 2022

Abstract
The scoring of crescents (Cs) was recently added to the Oxford classification for IgA nephropathy (IgAN). Because of the short-term use of the C score in clinical practice, its validity and applicability need to be verified. We, retrospectively, analyzed the clinicopathological data of 144 primary IgAN patients diagnosed at our hospital from March 2017 to March 2019 and with complete ≥6-month follow-up data. We found that the C score was positively correlated with the Lee’s classification in the assessment of renal pathological changes and significantly correlated with increased proteinuria and decreased estimated glomerular filtration rate. Univariate Cox regression analysis showed an association of C formation with IgAN prognosis, and multivariate Cox regression indicated Cs as an independent prognosis factor. The optimal proportion of Cs for prognosis prediction by the receiver operating characteristic curve was 11%. Kaplan–Meier survival curve revealed a significantly decreased renal survival rate in patients with C proportions ≥11%. Further multivariate Cox regression analysis confirmed that the C proportion ≥11% is an independent risk factor for poor prognosis of IgAN patients. Our findings demonstrate that Cs are independently related to the prognosis of patients with IgAN, and the proportion of Cs ≥11% is an independent risk factor for poor outcomes.
Expression of DNM3 is associated with good outcome in colorectal cancer
Authors: Cheng Shao-ang , Huang Xin , Jiang Liang , Liang Qi-Lian , Hong Xiao-Cui , Yang Hai-Xia , Hu Ke-Hui , Luo Xing-Bo , Zhang Hui-Jie 
Published: February 2022

Abstract
The aim of this study is to reveal the potential value of dynamin3 (DNM3) in colorectal cancer (CRC) evaluation of clinical diagnosis and prognosis. A total of 100 tissue samples were collected from 50 patients with stages I–IV, CRC tissues (n = 50) paired with non-cancerous adjacent colorectal tissues (n = 50). The expression levels of DNM3 were detected in 50 cases of CRC tissues and 50 cases of non-cancerous adjacent colorectal tissues by real-time fluorescent quantitative reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemical method (IHC) was conducted to semi-quantify the expression of DNM3 protein. Results showed that the relative expression of DNM3 mRNA in CRC tissues was 0.634-fold of that in non-cancerous adjacent colorectal tissues. The positive rate of DNM3 protein in CRC tissues (42.0%) was much lower than that in non-cancerous adjacent colorectal tissues (66.0%; P < 0.05). The expression level of DNM3 protein in CRC tissues was dependent on tumor size, degree of histological differentiation, and clinical stage (P < 0.05). The expression level of DNM3 mRNA in CRC tissues was significantly correlated with tumor size and pathology classification (P < 0.05). The research shows that detecting the expression of DNM3 helps in analyzing the tumor size, degree of histological differentiation, and clinical stage. Expression of DNM3 may be associated with good outcome in CRC.
The puzzle and persistence of biglaw clustering
Authors: Shill Gregory H. 
Published: February 2022

Abstract
Elite U.S.-based global law firms (“Biglaw” firms) concentrate in the costliest districts of superstar cities, especially two neighborhoods in Manhattan. This pattern has persisted despite both the dispersal of Biglaw clients across less-dense, lower-cost U.S. geographies and the development of telework capacity. It suggests a puzzle: law is among the occupations most conducive to remote work, yet Biglaw prior to the coronavirus pandemic required in-person work in the priciest places—meaning it paid (and continues to pay) a premium on both of its biggest expenses, wages and real estate. How might this equilibrium be explained, and what might lead it to change? This Article contends that Biglaw clustering reflects a management preference for the exploitation of proven strategies over the exploration of novel and uncertain ones—but that the pandemic telework experience is eroding this dichotomy. This analysis has direct implications for private international law (“PIL”) practice, where large-scale transactions and disputes are handled by Biglaw firms and involve significant international travel. This Article contributes to a growing literature on telework’s impacts on cities, labor markets, and industries, and is the first to extend that focus to Biglaw and PIL. A post-pandemic Biglaw embrace of dispersal via telework would destabilize standard accounts of collaboration in agglomeration economies. While the Article expresses skepticism about that outcome, it identifies a mechanism by which it might plausibly come about. Crucially, this mechanism—the replacement of an exploit vs. explore choice with two different exploit options—posits as the key driver not technology but management learning and innovation that quickened during the pandemic.
Prenatal exposure to glucocorticoids and the prevalence of overweight or obesity in childhood
Authors: Laugesen Kristina , Sørensen Henrik Toft , Jorgensen Jens Otto L , Petersen Irene 
Published: February 2022

Objective
Prenatal exposure to excess cortisol can affect postnatal metabolic health by epigenetic mechanisms. We aimed to investigate if prenatal exposure to pharmacological glucocorticoids increases the risk of overweight/obesity in childhood.

Design
A nationwide population registry-based cohort study.

Methods
We identified 383 877 children born in Denmark (2007–2012), who underwent routine anthropometric evaluation at 5–8 years of age. Prenatal exposure to glucocorticoids was divided into systemic and topical glucocorticoids, cumulative systemic dose, and use by trimester. The comparison cohort included children without exposure, born to maternal never-users. Negative control exposures were used to investigate confounding from an underlying disease or unmeasured characteristics. Such exposures included children without glucocorticoid exposure born to maternal users of non-steroidal anti-inflammatory drugs or immunotherapy during pregnancy, maternal former users of glucocorticoids, or paternal users of glucocorticoids during the pregnancy of their partner. We estimated sex-stratified adjusted prevalence ratios (aPR) of overweight/obesity at 5–8 years of age, as epigenetic modifications have shown to be sex-specific.

Results
In the study, 21 246 (11%) boys and 27 851 (15%) girls were overweight/obese at 5–8 years of age. Overall, neither systemic nor topical glucocorticoids were associated with overweight/obesity. In boys, high-dose systemic glucocorticoids was associated with higher prevalence of overweight/obesity vs the comparison cohort (aPR: 1.41 (95% CI: 1.07–1.86), prevalence: 16% vs 11%). Negative control exposures indicated robustness to confounding.

Conclusion
Overweight/obesity might be an adverse effect of prenatal exposure to high-dose systemic glucocorticoids in boys. We found no association for neither prenatal exposure to lower doses of systemic nor topical glucocorticoids. These results merit clinical attention.
Bypassing the Blood-Brain Barrier to Treat Brain Cancer: A Systematic Review of the Efficacy of Carmustine Wafer Implant Therapy
Authors:   Peter Tsivis, Sharobim Mark 
Published: February 2022

Introduction: Gliomas are neoplasms of the central nervous system (CNS). Despite aggressive treatment, median survival of malignant tumors remains poor at 12 - 18 months. Newer treatments allow delivery of therapeutic substances across the selectively permeable blood-brain barrier (BBB). This allows for chemotherapeutics to more easily reach their target location in the CNS. Drug eluting wafers made up of carmustine can be placed in the surgical resection cavity of a tumor and clinical trials to date have demonstrated their utility. Hypothesis: Bypassing the BBB to allow greater accumulation of chemotherapeutics in the CNS will improve clinical outcomes in glioma patients. Methods: Studies from medical literature databases describing trials using carmustine wafers implanted after glioma resection were obtained. To test our hypothesis, the available data using this therapy was compared to current first line treatment data for glioma as described by Stupp and colleagues. The inclusion criterion for efficacy analysis was histopathologically confirmed primary glioma. Exclusion criteria included presence of metastasis or pediatric tumors.	Results: 10 studies describing wafer therapy use were initially gathered, encompassing over 500 patients. 6 studies met criteria for treatment efficacy analysis. 4 of 6 (75%) trials exhibited significant survival advantage as compared to control treatment. Furthermore, 3 of the 4 (75%) studies showing significance also demonstrated equal or higher percent increase in overall survival from control as compared to data generated from current first line therapy. Conclusion: Treatments bypassing the BBB are not currently standard-of-care for patients with glioma. We uncovered that most trials using carmustine implants post tumor resection describe increased overall survival, however in specific cohorts. Diverting the BBB in general may also have fewer side effects in contrast to classical routes of therapy. Future work is needed to develop similar therapeutics that improve outcomes in all age, gender, and prognostic risk factor populations.
Розрахунок критичної температури бозе-газу з далекодійними силами
Authors: Пастухов В.С. 
Published: February 2022

У статті обчислено критичну температуру моделі бозе-газу зі степеневим законом залежності потенціальної енергії попарної взаємодії від відстані між частинками. У граничних випадках результат відтворює відомі результати з літератури. У наближенні хаотичних фаз (RPA) проаналізовано параметри спектра колективних збуджень моделі та отримано довгохвильову асимптотику структурного фактора системи при температурах, вищих за температуру фазового переходу.