bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential regulatory mechanism of TNF-α/TNFR1/ANXA1 in glioma cells and its role in glioma cell proliferation
Authors: Zhu Xiaotian , Shi Guanhui , Lu Jinbiao , Qian Xin , Wang Donglin 
Published: March 2022

Abstract
The purpose of this study was to explore the regulatory mechanism of Annexin A1 (ANXA1) in glioma cells in the inflammatory microenvironment induced by tumour necrosis factor α (TNF-α) and its effects on glioma cell proliferation. CCK-8 analysis demonstrated that TNF-α stimulation promotes rapid growth in glioma cells. Changes in tumour necrosis factor receptor 1 (TNFR1) and ANXA1 expression in glioma cells stimulated with TNF-α were revealed through western blot analysis and immunofluorescence staining. Coimmunoprecipitation analysis revealed that ANXA1 interacts with TNFR1. Moreover, we found that ANXA1 promotes glioma cell growth by activating the p65 and Akt signalling pathways. Finally, immunohistochemistry analysis showed an obvious correlation between ANXA1 expression and Ki-67 in glioma tissues. In summary, our results indicate that the TNF-α/TNFR1/ANXA1 axis regulates the proliferation of glioma cells and that ANXA1 plays a regulatory role in the inflammatory microenvironment.
Statistical analysis on the radiological assessment and geochemical studies of granite rocks in the north of Um Taghir area, Eastern Desert, Egypt
Authors: Awad Hamdy A. , Abu El-Leil Ibrahim , Nastavkin Aleksey V. , Tolba Abdellah , Kamel Mostafa , El-Wardany Refaey M. , Rabie Abdalla , Ene Antoaneta , Tekin Huseyin O. , Issa Shams A. M. , Zakaly Hesham M. H. 
Published: March 2022

Abstract
Granite rocks are currently one of the foremost raw materials that can be used for various economic purposes such as ornamentation and building materials, because they do not possess radioactive concentrations and have good physical and mechanical properties. The granite rocks of north Um Taghir are connected to neoproterozoic rocks and integrated to the north Arabian-Nubian Shield (ANS), which lies in Northeast Africa. Inductively coupled plasma mass spectrometry (ICP-MS) and X-ray fluorescence analysis, concurrent to some statistical analysis, have been carried for major oxides and some trace elements to extract much fundamental information by following certain mathematical methods. The exposed granite rock units in north Um Taghir are classified into four rock units represented by tonalite, granodiorite, monzogranite, and alkali-feldspar granite which are cut by different types of dikes. The magma of tonalite and granodiorite is low-to-medium K calc-alkaline affinity, while the magma of monzogranite and alkali-feldspar granite is medium-to-high K calc-alkaline affinity, and of metaluminous to peraluminous nature. Granite rocks show a slightly depletion of fractionated patterns from light rare earth elements (LREEs) to heavy rare earth elements (HREEs) with slightly positive to negative Eu anomalies from tonalite to monzogranite and alkali-feldspar granites. The statistical criteria have been achieved to explore the significant differences of radiological hazard parameters among samples. It is obvious that there is no homogeneity among samples; furthermore, in Kruskal–Wallis test, Mann–Whitney test, and Pearson correlation coefficient, it can be noticed that there are significant differences between each pair of samples: tonalite, monzogranite; tonalite, alkali-feldspar granite; granodiorite, monzogranite; and granodiorite, alkali-feldspar granite. There is a strong direct relationship among granodiorite and both tonalite and alkali-feldspar granite, and among alkali-feldspar granite and tonalite and granodiorite. There is a strong inverse relationship among monzogranite and tonalite, granodiorite, and alkali-feldspar granite. As stated by all results, it can be mentioned that the granite rocks have a worthy result of mechanical and physical properties. So that they can be used for various economic purposes.
The investigation of ferro resonance voltage fluctuation considering load types and damping factors
Authors: Shemshadi Asaad , Khorampour Pourya 
Published: March 2022

Abstract

Background and Objectives: The occurrence of ferro resonance is a very complex phenomenon in power systems. In circuits including inductors and capacitors, if the value of zc = zl becomes, an intensification or resonance state is created in the circuit. In circuits and networks that have saturated inductors, nonlinear resonance or ferro resonance is created, Ferro resonance is a nonlinear resonance phenomenon that occurs between the network capacitor and the nonlinear inductance of the transformer during saturation. Ferro resonance at the main frequency and higher frequencies cause insulation problems and at low frequencies causes thermal problems. In the event of this phenomenon, the voltage range increases to a considerable extent and may also be distorted, which due to the structure of the winding connections in transformers can cause damage to electrical installations. Methods: In this paper, we study and simulate the phenomenon of ferro resonance and provide solutions such as using high resistance on the primary side of the transformer and the combination of resistors and inductors on the secondary side of the transformer to damp the ferro resonance in MATLAB software. Furthermore, the utilization of surge arresters is discussed in detail. Results: It is illuminated that utilization of suggested approaches has an acceptable reduction rate on the damping of ferro resonance fluctuations. Especially when using resistor and inductor simultaneously the fluctuations reduce and ferro resonance is damped immediately. Conclusion: It is important to pay attention to the transformer and the amount of capacitors in transmission lines, especially cable lines. Furthermore, asymmetric switching is another important factor. High resistance can reduce fluctuations but causes power losses in the circuit but using Resistance and inductor structure are able to create acceptable damping and reduce fluctuations without loss problems. The presence of a surge arrester can also reduce the overvoltage caused by ferro resonance to an appropriate level.
Engagementpolitik und Demokratiepolitik
Authors: Klein Ansgar 
Published: March 2022

ZusammenfassungMit dem Begriffsverständnis des „bürgerschaftlichen Engagements“ eng verbunden ist ein normatives Verständnis, in dem die politischen Gestaltungsansprüche als wesentlicher Bestandteil eines immer eigensinnigen und freiwilligen Engagements gelten. Engagement und Partizipation haben in diesem neueren Verständnis einen engen und nicht auflösbaren Zusammenhang, weil die Gestaltung der Gesellschaft im Kleinen durch Engagement die Bezüge zu den darauf gerichteten politischen Entscheidungen und zugleich Beteiligungsansprüche schafft. Daher hat Engagementpolitik immer auch enge Bezüge zur Demokratiepolitik. In der Folge der Enquete-Kommission haben sich über die Aktivitäten von Bund, Ländern und Kommunen die neuen und fragilen Politikfelder der „Engagementpolitik“ wie auch – damit eng verbunden – der „Demokratiepolitik“ entwickelt. Auf Empfehlung der Kommission wurde 2002 das Bundesnetzwerk Bürgerschaftliches Engagement (BBE) gegründet, um zu Fragen von Engagement und Zivilgesellschaft die Interessen und Problemperspektiven aus Zivilgesellschaft, Staat und Wirtschaft zu verschränken und gemeinsam fortzuentwickeln. Der Beitrag gibt einen Überblick über diese Entwicklungen.
Koalition des Aufbruchs in eine moderne Zivilgesellschaft
Authors: Fester Emilia 
Published: March 2022

Zusammenfassung
Emilia Fester reflektiert in ihrer Rolle als jüngste Abgeordnete des Bundestags Themen rund um Engagement und Ehrenamt. Dabei geht sie auf konkrete Meilensteine ein, die durch den Koalitionsvertrag erreicht werden konnten und setzt diese in den übergeordneten politischen Kontext. Wertschätzung von Ehrenamt, Anerkennung von Freiwilligendiensten und Respekt für eine freie Zivilgesellschaft müssen aus Sicht der GRÜNEN vielerorts neu positioniert werden. Solch angestrebte Paradigmenwechsel sollten dabei nicht zuletzt in Förderpolitiken und Haushaltserwägungen sichtbar werden, so Fester.
Demokratiepolitik – Erfolge und Herausforderungen in Deutschland
Authors: Roth Roland 
Published: March 2022

ZusammenfassungZu den demokratiepolitischen Erträgen der letzten Dekade gehört eine beachtliche Ausweitung des Handlungsrepertoires. Dies gilt vor allem für dialogische und deliberative Beteiligungsformate, aber auch für neue direktdemokratische Formen wie Bürgerfonds und Budgets. Neue Leitbilder wie „vielfältige Demokratie“ oder „Bürgerkommune“ sind entstanden und werden praktisch erprobt. Damit sind Umrisse progressiver Antworten auf Erosionen des klassischen Gefüges repräsentativer Politik und autoritäre Rückbildungen sichtbar geworden.Eine offene Frage ist, wie eine Ausbreitung dieser demokratischen Experimente gelingen kann. Die Devise „mehr Fortschritt wagen“, mit der die neue Bundesregierung angetreten ist, hat bislang kein zureichendes demokratiepolitisches Fundament. Nur wenn die demokratiepolitischen Innovationen des letzten Jahrzehnts auch breit genutzt werden, kann sie erfolgreich sein.
Use of Circular Dichroism in the characterization of the fusion protein SARS-CoV-2 S protein (RBD)-hFc
Authors: Ruíz Ingrid , Gómez Jose A. , García Laura 
Published: March 2022

Abstract
From the receptor-binding domain (RBD) of the SARS-CoV-2 virus, which causes coronavirus disease 2019 (COVID-19), a RBD-hFc fusion protein was obtained at the Center of Molecular Immunology (Havana, Cuba). This fusion protein was used in the construction of a diagnostic device for COVID-19 called Ultramicroenzyme-Linked Immunosorbent Assay (UMELISA)-SARS-CoV-2-IgG and it is currently been used in the studies of biological activity of the Cuban vaccine Abdala (CIGB-66). In this work, Circular Dichroism (CD) is used to characterize this protein. Using Far Ultraviolet Circular Dichroism (FAR-UV CD), it was determined that the protein has a secondary structure in the form of a sheet-β fundamentally. Using this technique, a thermodynamic study was carried out and it was determined that the melting temperature (Tm) of the protein is 71.5 °C. Information about the tertiary structure of the protein was obtained using Near Ultraviolet Circular Dichroism (NEAR-UV CD) and Molecular Fluorescence; they indicates that the protein has a three-dimensional folding associated with the aromatic amino acids in its structure, where tryptophan (Trp) is located inside the folded structure of the protein while tyrosine (Tyr) is exposed to the solvent.
Facilitation of processingdarenimo‘any/everyone’ negative Japanese sentences using prosodic entrainment
Authors: Tamaoka Katsuo , Ji Yuanyuan 
Published: March 2022

AbstractThe present study examined how prosody affects Japanese speakers’ processing of the polarity itemdarenimo‘any/everyone’. Upward (LHHH pitch) and downward (HLLL pitch) prosody fordarenimoassociates with negative and positive polarity, respectively. In Study 1, a corpus search showed thatdarenimois more often associated with negative than positive polarity. In Study 2, subjective acceptability judgments indicated thatdarenimois also more likely to be perceived as acceptable by native Japanese speakers when used with negative polarity. In line with Study 2, Study 3 showed that upward prosody with negative polarity was more accurately and quickly processed than was downward prosody with either positive or negative polarity. These three studies showed a one-sided distribution of upward prosody with negative polarity, and further indicated that only upward prosody facilitates listeners’ processing of negation. Early heightened pitch ofdarenimoprovides a cue to predict an ending negation -naiin the head-final Japanese language, resulting in faster speed and higher accuracy for the processing of negative sentences (i.e., a facilitation effect) compared to their corresponding affirmative sentences.
Synthesis and characterization of nano-SiO2@octadecylbisimidazoline quaternary ammonium salt used as acidizing corrosion inhibitor
Authors: Liu Yunfeng , Chen Lili , Tang Yongfan , Zhang Xingde , Qiu Zhengsong 
Published: March 2022

AbstractAiming at the current situation that the existing acidizing corrosion inhibitors are difficult to apply in high temperature, high concentration acid, and other complex conditions, this article uses nano-SiO2as the core and preferably functional monomers to synthesize nano-SiO2@octadecylbisimidazoline quaternary ammonium salt (nano-SiO2@OBQA). Analytical methods such as nuclear magnetic resonance, infrared, and scanning electron microscopy were used for characterization. The corrosion inhibition performance of the N80 steel sheet by nano-SiO2@OBQA in 20% concentrated hydrochloric acid was studied using the high-temperature corrosion testing machine and adsorption isotherm model combined with quantum chemistry calculations to explore its mechanism of action. The results show that nano-SiO2@OBQA has good high-temperature resistance. When the temperature is 180℃ and the dosage of nano-SiO2@OBQA is 4%, the corrosion inhibition rate is 61.42 g·m−2·h−1. Studies have shown that the adsorption of nano-SiO2@OBQA on the surface of the N80 steel sheet follows the Langmuir isotherm adsorption model, which is spontaneous chemical adsorption.
A recursive prefix in Neasu
Authors: Gerner Matthias 
Published: March 2022

AbstractNeasu (Tibeto-Burman: China) exhibits a prefix that derives new coordinators from existing ones by elaborately changing their subcategorial properties. Prefixed and unprefixed coordinators are distinguished by the complement they take (±verbal, ±CoP) and the possibility of being stacked up at least twice (±stackable). A prefixed coordinator has two of these three features switched from “−” to “+”, when compared with its unprefixed counterpart and thus see its ability to occur as the head of recursive coordination structures increased. The prefixao- is an operatorofrecursion.
Multiple Manufacturing Processing Target Value Setting Models: A Case Study on Grinding and Polishing Processes of the Electric Vehicle Motor Shaft
Authors: Chen Kuen-Suan , Hung Yung-Hsiang , Su Yuan-Tsung 
Published: March 2022

AbstractAiming to reduce the social-economic loss caused by deficient products, the processing target value setting requirements must be achieved through multiple manufacturing processes. Meanwhile, the processing target value setting for each step must properly match its own manufacturing process capability so as to lower the ratios of process scrap and rework. Consequently, the quality of the final product can be ensured to reduce social-economic loss, such as carbon emissions caused by faulty maintenance after sales. By means of the production data analysis as well as quality engineering, this study discovered the best conditions for multiple manufacturing processes and then adopted the genetic neural networks method to estimate the optimal stable-process standard deviation for each processing step. Next, according to the aforementioned optimal process standard deviation, the reasonable target value of each processing step was determined by the processing target value and the process capability set in the final product. Finally, this study provided the multiple-process capability analysis chart to evaluate the process capability after experiment. The processing of the green electric vehicle motor was taken as an example to explain the application of the reasonable processing target value setting model mentioned in this study.
EDITORIAL
Authors: Iriondo Otero Walter Ruben 
Published: March 2022

A Equipe Editorial tem o prazer de apresentar um novo número da Revista Prociências, correspondente à última publicação regular da Revista para o ano 2021. As contribuições que compõem esta edição foram submetidas por investigadores do Brasil e do Exterior, notadamente, da Colômbia, México, e dos Estados brasileiros da Bahia, Espírito Santo, Pará, Rio Grande do Sul, e Santa Catarina.
Os artigos que integram o presente número apresentam resultados de pesquisas que versam sobre diversos desafios contemporâneos, na esfera do sistema educativo e no âmbito da gestão organizacional. Referente ao sistema educativo, apresentam-se investigações que abordam a aprendizagem no ensino superior baseada em problemas; a robótica educacional com foco em pessoas neurodiversas; os jogos e o transtorno do espectro autista; e a escala comum de valores em grupos de aprendizagem na educação a distância. Com respeito à abordagem direcionada às questões de gestão organizacional, incluíram-se nesta edição trabalhos que tratam da melhoria do processo de corte de tecidos na indústria têxtil; da gestão patrimonial de bens móveis; e do sistema de gerenciamento de atendimentos em instituições financeiras.
Cabe lembrar que a Revista Prociências aceita propostas da comunidade científica internacional para publicação de Edições Especiais, no formato Dossiê ou Edição Temática. Também vale mencionar que a Revista recebe contribuições em fluxo contínuo durante o ano todo, ou seja, é ininterrupto o recebimento de propostas e artigos inéditos para as próximas edições da Revista.
Assim sendo, reafirma-se o compromisso desta Equipe Editorial com a divulgação do conhecimento científico e com um projeto editorial interdisciplinar de qualidade, somado ao desejo de uma profícua leitura desta edição da Revista Prociências.

Walter R. Iriondo Otero
Editor
Numerical analysis of wake turbulence between hybrid tidal turbine and hypothetical actuator cylinder for shallow water with low velocity conditions
Authors: Dass Lakshuman , Abdul Rahman Anas , Rajendran Kumaran , Suhri Gisrina Elin 
Published: March 2022

Towards modernisation of the technological era, electricity demands have been an issue. Although the supply of electrical energy from the renewable sources are increasing, it is still not sufficient to offset the carbon production. Malaysia as a developing country needs ample of supply of electrical energy. As most of the current electrical energy for the country are being produced by non renewable sources, the Malaysian government have started looking into renewable options to produce electrical energy. There are various sources of energy that are available in Malaysia such as solar, natural gas, petroleum, ocean energy and many more. This paper is focused on the tidal energy which is an ocean energy that can produce electrical energy by using the power of tide. This research explores the hybrid turbine design which is a type of vertical-axis tidal turbine that combines two distinct type of devices, namely Savonius and H-Darrieus turbines. Hybrid turbine is useful as it helps to overcome the limitation of individual turbine and also be able to produce energy at a low water velocity. Numerical analysis is employed to investigate the wake recovery behaviour and turbulent mixing due to the positioning of the device using Ansys CFD Fluent. By understanding the general wake characteristics produced by each device, proper planning can be done to configure these devices in an array for future planning. The simulation result shows that the hybrid turbine utilising NACA0015 and NACA0018 with nested configuration demonstrates faster velocity recovery compared to NACA0021. The turbulence wake results also provides a promising output which shows the acceleration of flow at the downstream region for hybrid nested NACA0015 and NACA0018 are more narrow compared to NACA0021. The result of this simulation has also been validated with published data. In a nutshell, the NACA blade design not only affects the performance of the turbine but can also influence the velocity recovery downstream of the device.
Contribution of cerebral microvascular mechanisms to age-related cognitive impairment and dementia
Authors: Fang Xing , Crumpler Reece F. , Thomas Kirby N. , Mazique Jena’ N. , Roman Richard J. , Fan Fan 
Published: March 2022

Abstract
Cognitive impairment and dementia are significant health burdens worldwide. Aging, hypertension, and diabetes are the primary risk factors for Alzheimer’s disease and Alzheimer’s disease and related dementias (AD/ADRD). There are no effective treatments for AD/ADRD to date. An emerging body of evidence indicates that cerebral vascular dysfunction and hypoperfusion precedes the development of other AD pathological phenotypes and cognitive impairment. However, vascular contribution to dementia is not currently well understood. This commentary highlights the emerging concepts and mechanisms underlying the microvascular contribution to AD/ADRD, including hypotheses targeting the anterograde and retrograde cerebral vascular pathways, as well as the cerebral capillaries and the venous system. We also briefly discuss vascular endothelial dysfunction, oxidative stress, inflammation, and cellular senescence that may contribute to impaired cerebral blood flow autoregulation, neurovascular uncoupling, and dysfunction of cerebral capillaries and the venous system.
Study on Bhutan Census Grid Square Data Creation
Authors: Neki Kazuyuki 
Published: March 2022

It is highly demanded to urgently maintain accurate GIS statistical data as the importance of planning a sustainable development plan due to widening disparities and inequalities; addressing new social challenges arising from rapid development and urbanization. As a former study of this paper proved the significance of creating the grid square statistics and the effectiveness of adopting the World Grid Square system rather than developing a dedicated system for Bhutan, in the context of the United Nations General Assembly adopted the UN resolution on Global Geodetic Reference Frame for Sustainable Development that was led by the Republic of Fiji in 2015.Currently in Bhutan, important
GIS statistical data (e.g. population) is available only in large administrative levels, namely Gewog/Thromde (city-level), however GIS statistical data in smaller levels are required to conduct a detailed study on the new social challenges. This Grid Square system can be quickly adopted from open sources and provide granular information in smaller areas than cities and villages with a precise and globally adopted geodetic reference frame.There are two major objectives of this paper; (1) Creating practical GIS statistic data in the grid square format. (2) Clarifying the advantages, disadvantages and difficulties, in order to evaluate and improve the grid square format. Within the limitation of data availability in Bhutan, this study has assumed the population of each grid square covering the whole census area of Thimphu Thromde by an estimation model using sampled data in Enumeration Areas (EA) of ‘2017 Population & Housing Census of Bhutan’. Further, this paper discusses advantages and disadvantages between EA-units and grid squares on the presumption of taking suppression measurements and
resampling from EA-units to grid squares. Consequently, we conclude that using the grid square format in practice could improve the efficiency of GIS analysis and data availability although there is one drawback in accuracy. Moreover, the population of each EA-unit has been predicted by the model comprising GIS-based variables (e.g. distance from facilities). The result has been validated by the whole population in Thimphu thromde. Accessibility to health and educational facilities is the most significant factor for the number of people living in the area.