bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venous Thromboembolism in Patients Undergoing Distal Cholangiocarcinoma Surgery: Prevalence, Risk Factors, and Outcome
Authors: Chen Qing , Cui Songping , Huang Jincan , Wang Jing , Wang Di , Wang Hanxuan , Lyu Shaocheng , Lang Ren 
Published: November 2022

Abstract
Background: To investigate venous thromboembolism (VTE) in patients undergoing distal cholangiocarcinoma (dCCA) surgery, we performed a single-center study to assess its prevalence, risk factors, prognosis.
Method: We studied a total of 177 patients undergoing dCCA surgery from January 2017 to April 2022. Demographic, clinical data, laboratory data (including lower extremity ultrasound findings), and outcome variables were obtained, and compared between VTE and non-VTE groups.
Results: Of the 177 patients undergoing dCCA surgery (aged 65.2±9.6years; 108 (61.0%) male), 64 patients developed VTE after surgery. Logistic multivariate analysis showed that, age, operation procedure, TNM stage, ventilator duration and preoperative D-dimer were independent risk factors. Based on these factors, we constructed the nomogram to predict VTE after dCCA for the first time. The areas under the receiver operating curve (ROC) of the nomogram were 0.80 (95% CI: 0.72-0.88) and 0.79 (95% CI: 0.73-0.89) in the training and validation groups, respectively. Patients developed VTE had a worse prognosis by Kaplan-Meier curve analysis (p = 0.001).
Conclusion: The prevalence of VTE is high and is associated with adverse outcomes in patients undergoing dCCA surgery. We developed a nomogram assessing VTE risk, which may help clinicians to screen out people at high risk for VTE and to undertake rational preventive measures.
A pH-Responsive Metal−Organic Framework for the Co-delivery of HIF-2α siRNA and Curcumin for Enhanced Therapy of Osteoarthritis
Authors: Zhang Zi-Jian , Hou Ying-Ke , Chen Ming-Wa , Yu Xue-Zhao , Chen Si-Yu , Yue Ya-Ru , Guo Xiong-Tian , Chen Jin-Xiang X. , Zhou Quan 
Published: November 2022

Abstract
The occurrence of osteoarthritis (OA) is highly correlated with the reduction of joint lubrication performance, in which persistent excessive inflammation and irreversible destruction of cartilage dominate the mechanism. The inadequate response to monotherapy methods, suboptimal efficacy caused by undesirable bioavailability, short retention, and lack of stimulus-responsiveness, are few unresolved issues. Herein, we report a pH-responsive metal-organic framework (MOF), namely, MIL-101-NH2, for the co-delivery of anti-inflammatory drug curcumin (CCM) and small interfering RNA (siRNA) for hypoxia inducible factor (HIF-2α). CCM and siRNA were loaded via encapsulation and surface coordination ability of MIL-101-NH2. Our vitro tests showed that MIL-101-NH2 protected siRNA from nuclease degradation by lysosomal escape. The pH-responsive MIL-101-NH2 gradually collapsed in an acidic OA microenvironment to release the CCM payloads to down-regulate the level of pro-inflammatory cytokines, and to release the siRNA payloads to cleave the target HIF-2α mRNA for gene-silencing therapy, ultimately exhibiting the synergetic therapeutic efficacy by silencing HIF-2α genes accompanied by inhibiting the inflammation response and cartilage degeneration of OA. The hybrid material reported herein exhibited promising potential performance for OA therapy as supported by both in vitro and in vivo studies and may offer an efficacious therapeutic strategy for OA utilizing MOFs as host materials.
Analysis of a Gray-Box Operator for Vertex Cover
Authors: Baguley Samuel , Friedrich Tobias , Kötzing Timo , Li Xiaoyue , Pappik Marcus , Zeif Ziena 
Published: November 2022

Abstract
Combinatorial optimization problems are a prominent application area of evolutionary algorithms, where the (1+1) EA is one of the most investigated. We extend this algorithm by introducing some problem knowledge with a specialized mutation operator which works under the assumption that the number of 1s of a solution is critical, as frequently happens in combinatorial optimization. This slight modification increases the chance to correct wrongly placed bits while preserving the simplicity and problem independence of the (1+1) EA. As an application of our algorithm we examine the vertex cover problem on certain instances, where we show that it leads to asymptotically better runtimes and even finds with higher probability optimal solutions in comparison with the usual (1+1) EA. Precisely, we compare the performance of both algorithms on paths and on complete bipartite graphs of size n. Regarding the path we prove that, for a particular initial configuration, the (1+1) EA takes in expectation Θ(n4) iterations while the modification reduces this to Θ(n3), and present experimental evidence that such a configuration is reached. Concerning the complete bipartite graph our modification finds the optimum in polynomial time with probability 1−1/2Ω(nξ) for every positive constant ξ < 1, which improves the known probability of 1 − 1/poly(n) for the (1+1) EA.
An Approach to Estimate Optimal Cut-off Time under Deficit Irrigation
Authors: Ghorbanian Mohammad , Ojaghlou Hassan , Ebrahimian Hamed 
Published: November 2022

Abstract

The use of deficit irrigation technique has become inevitable due to the lack of water resources in many parts of the world. The goal of this study is to improve the performance of border irrigation under deficit strategy by determining the optimal cutoff time (Tco). For this purpose, field experiments and simulation modeling were carried out. The experimental borders were different in terms of inflow discharge, soil texture and length. 1024 combinations included different physical and management factors were analyzed by the WinSRFR software. By determining the optimal Tco for each combination, fifteen regression equations were extracted for three irrigation levels and five advance times (Ta) (times when water advanced to 30 to 70% of the border lengths). Two indexes including Y (combination of efficiency and uniformity indices) and Y′ (combination of efficiency, uniformity, and requirement efficiency) were used to evaluate border irrigation performance. Based on the validation results, the relationship between Tco and Ta at the 70% of the border length was introduced as a suitable option. The performance of the selected equation was evaluated using the field data. The results illustrated that the calculated values of Y and Y′ from the proposed method was in high agreement with theses from the common optimization method. Tco obtained from the proposed relationship improved the Y and Y′ indices by 9.4 and 6.6%, respectively, compared to the field conditions. The proposed relationship will guarantee application efficiency above 60%, uniformity and requirement efficiency above 80%.
Application of frequency ratio, information value, and weights-of-evidence models and their comparison in landslide susceptibility mapping in Murree region, Sub-Himalayas
Authors: Islam Fakhrul , Iqbal Muhammad Farooq , Mahmood Irfan , Shahzad Muhammad Imran , Shah Safeer Ullah 
Published: November 2022

Abstract
Landslide is a chronic geohazard in hilly regions which affects the socioeconomic trends globally. Current study is conducted to apply three models including Information Value (IV), Frequency Ratio (FR) and Weights of Evidence (WoE) for Landslide Susceptibility Mapping (LSM) of Murree. Sentinel-2, Google Earth, and field surveys data were used to generate an inventory map of 102 landslides and these events were divided into two subsets i.e., 70% and 30% for LSM and model validation respectively. Eleven causative factors including soil erosion, elevation, slope, aspect, curvature, drainage, fault, road, precipitation, Land Use Land Cover (LULC), and lithology maps were prepared using Google Earth Engine (GEE). The final susceptibility maps were produced with the training datasets of landslide events and causative factors using IV, FR and WoE, whereas these maps were validated using the Receiver Operating Characteristic (ROC) technique. The Area Under Curve (AUC) illustrated the Success Rate Curve (SRC) of 69%, 78% and 79% for the IV, FR and WoE models, respectively, while Predicted Rate Curve (PRC) were 80%, 95% and 87% for the IV, FR and WoE models, respectively. The results of this study can be used by policymakers to plan some mitigation regarding soil erosion and landslides-prone region.
Functional connectivity changes in the insular subregions of patients with obstructive sleep apnea after 6 months of continuous positive airway pressure treatment: a resting-state functional magnetic resonance imaging study.
Authors: Long Ting , Li Haijun , Shu Yongqiang , Li Kunyao , Xie Wei , Zeng Yaping , Huang Ling , Zeng Li , Liu Xiang , Peng Dechang 
Published: November 2022

Abstract
This study aimed to investigate the functional connectivity (FC)changes between the insular subregions and whole brain in patients with obstructive sleep apnea (OSA) after 6 months of continuous positive airway pressure (CPAP) treatment and to explore the relationship between resting-state FC changes and cognitive impairment in OSA patients. Data from 15 patients with OSA before and after 6 months of CPAP treatment were included in this study. The FC between the insular subregions and whole brain was compared between baseline and after 6 months of CPAP treatment in OSA. After 6 months of treatment, OSA patients had increased FC from the right ventral anterior insula to the bilateral superior frontal gyrus and bilateral middle frontal gyrus, and increased FC from the left posterior insula to the left middle temporal gyrus and left inferior temporal gyrus. Hyperconnectivity was found from the right posterior insula to the right middle temporal gyrus, bilateral precuneus, and bilateral posterior cingulate cortex, which mainly involved the default mode network. FC changes among the right posterior insula, bilateral precuneus, and bilateral posterior cingulate cortex were correlated with depression and anxiety scores.There are changes in functional connectivity patterns between the insular subregions and whole brain in OSA patients after 6 months of CPAP treatment. These changes provide a better understanding of the neuroimaging mechanisms underlying the improvement in cognitive function and emotional impairment in OSA patients and can be used as potential biomarkers for clinical CPAP treatment.
Shi-style Steaming and Bathing Decoction on Knee Osteoarthritis by Decreasing Synovial Fibrosis and Angiogenesis
Authors: Wen Shengyue , Tian Biao , Lin Xun , Yuan Kaiwen , Cao Yuelong , Zhan Hongsheng , Chen Bo 
Published: November 2022

Abstract
Aim of the study:
A discussion of the effect of Shi-style steaming and bathing decoction on synovial fibrosis and vascular hyperplasia.
Materials and methods
An anterior cruciate ligament transection (ACLT method) was used to replicate the knee osteoarthritis (KOA) model. After 4 weeks, and synovial tissues were taken for hematoxylin-eosin staining (HE) and Krenn score to verify whether the KOA model was successfully established. After the 4-week successful modeling, each group used different interventions for 4 weeks, while the sham-operated and KOA model groups were not intervened. At the end of the intervention, HE staining and Masson staining were used and Krenn scores and positive fiber areas were calculated.Femoral artery blood flows in the right lower limb was detected with a color Doppler ultrasound machine. The protein expression level of VEGFA was determined by enzyme-linked immunosorbent assay and immunohistochemical assay, and the quantitatively analyze the mRNA of VEGFA using Real-time PCR .
Results
The animals in Shi-style steaming and bathing decoction herbal bath treatment group generally performed well. HE staining, Krenn score and Masson staining indicated that Shi-style steaming and bathing decoction herbal baths reduced the number of synovial inflammatory cells, attenuated synovial fibrosis, decreased blood flow velocity, alleviated vascular resistance, and decreased the protein expression level of VEGFA in vivo and the mRNA expression level.
Conclusions
In the rabbit KOA model, Shi-style steaming and bathing decoction herbal bath at 40°C can alleviate synovial inflammation, fibrosis and revascularization, and improve local blood circulation of the knee joint. Therefore, it is feasible for the treatment of knee osteoarthritis.
The Effect of Subcutaneous Fat Volume on Sunburn
Authors: Kong Jingyi , Zhao Wanchen , He Jinshen 
Published: November 2022

AbstractImportance: Excessive exposure to sunlight is common in people's lives, which will lead to sunburn and even some skin diseases. Although previous researches have explored many relevant factors for sun damage, not much is known about what effect subcutaneous fat volume has on sun damage. Objective Our study aims to show the effect subcutaneous fat volume has on sun damage and try to explain the mechanism behind. Method, Setting: Our Cross-sectional study conducted with individuals aged 20–59 at NHANES during 2017–2018. The total of 2373 participants were divided into two groups according to the degree of sun damage. Then we analyzed data by constructing three multivariable linear regression models and smooth curve fitting. Participants: We collected data of individuals’ degree of reaction to the same sun exposure, subcutaneous fat volume, age, gender, race and other essential factors during 2017–2018 at baseline (n = 5286). We excluded participants with missing answers of subcutaneous fat volume (n = 1868), missing answers of skin reaction to sun after non-exposure (n = 920) and missing answers of other factors (n = 125). The rest participants were divided into two groups according to the degree of sun damage. Exposure: After several months of not being in the sun, the participants were exposed to the sun without sunscreen or protective clothing for half an hour. Main Outcome and Measure: The result showed that the person who has more serious skin reaction to sun is likely to have less subcutaneous fat volume. The association remained significant among both gender groups and various subgroups defined by race. Conclusion The person who has more serious skin reaction to sun is likely to have less subcutaneous fat volume. It will make people more aware of the role of subcutaneous adipose tissue in the protection of the dermis, epidermal layer and in sun protection. Give some ideas to the research of the function of subcutaneous adipose tissue.
De nova assembly, annotation and comparative genomics study on the draft genome of Indian brackish water shrimp Caridina pseudogracilirostris
Authors: SoundharaPandiyan NandhaGopal , Rajaretinam Rajesh Kannan , Alphonse Carlton Ranjith Wilson , Thanumalaya Subramoniam , Gnana Prakash Vincent Samuel 
Published: November 2022

Abstract
The caridean shrimp Caridina pseudogracilirostris (order-Decapoda, family-Atyidae) is commonly found in the brackish waters of the southwestern coastal regions of peninsular India. The draft genome sequencing of this shrimp was carried out by Illumina NovaSeq6000 platform. We obtained a draft genome assembly of C. pseudogracilirostris (1.3 Gbp; 6,03,962 scaffolds; scaffold N50 = 2641 bp; 35.71% GC, 52.8% BUSCO completeness). It revealed that 24.60% of the genomic sequences are repetitive and has high proportion of simple sequence repeats (SSR) spanning 7.26% of the entire genome. Other major repeat classes found are Retroelements (3.19%), LINEs (2.37%) and L2/CR1/Rex (1.05%). A total of 14101 genes were identified with AUGUSTUS. The predicted genes were functionally annotated using EggNOG-mapper and the genes containing database hits were sorted based on the biological processes using Panther database. Genes associated with developmental process (31), cellular process (30), immune system process, (20) and reproductive process (24) were further analyzed in pathway commons and narrowed down into genes involved in regulatory pathways. We have conducted a comparative study with 15 crustacean species using OrthoFinder. It provided the phylogenetic species tree and a total of 7396 orthogroups were identified. C. pseudogracilirostris has shown only 3.7% orthologous genes.
A bounded constraint-based approach to aid for error localization from a counterexample
Authors: Bekkouche Mohammed 
Published: November 2022

Abstract
A model checker can produce a trace of counter-example for an erroneous program, which is often difficult to exploit for locating errors. In this paper, we proposed an error localization algorithm from counter-examples, named {\tt LocFaults}, combining approaches of Bounded Model-Checking (BMC) with a constraint satisfaction problem (CSP). The input is a faulty program for which a counter-example and a postcondition are provided. To identify helpful information for error location, {\tt LocFaults} analyzes the paths of CFG (Control Flow Graph) of the erroneous program to calculate the subsets of suspicious instructions to correct the program. Indeed, we generate a system of constraints for paths of control flow graph for which at most k conditional statements can be wrong. Then we calculate the MCSs (Minimal Correction Sets) of limited size on each of these paths. The removal of one of these sets of constraints yields a maximal satisfiable subset, in other words, a maximal subset of constraints satisfying the post condition. {\tt LocFaults} has been experimentally evaluated on a set of academic and realistic programs. The main advantage of this flow-driven approach is that the computed sets of suspicious instructions are small, each of them being associated with an identified path. Moreover, the constraint programming based framework of {\tt LocFaults} allows mixing Boolean and numerical constraints in an efficient and
straightforward way.
MaxEnt modelling in predicting habitat suitability for Syzygium alternifolium - An endangered species from Eastern Ghats, India.
Authors: Pattanaik S. , Koteshwar P. , Hembram K. , Ashok D. 
Published: November 2022

Abstract

Syzygium alternifolium (Wight) Walp. is a medium-sized tree economically exploited locally for its medicinal uses. Its seeds, fruit pulp, leaves and bark are used locally in ayurvedic medicines for the treatment of various ailments. It is an endemic and endangered species that is narrowly confined to the southern parts of Eastern Ghats, India. To understand its ecological and geographic distribution and to identify potential habitats for its introduction/reintroduction to assist its recovery from the endangered category, we used MaxEnt for ecological niche modeling (ENM), taking one hundred sixty-six species occurrences and twenty-six climatic and topographical datasets as input. The MaxEnt model has identified five variables having maximum bearing on S. alternifolium distribution and has successfully reconstructed the species’ geographic distribution in the Seshachalam, Veligonda and Lankamalla hill ranges of Eastern Ghats. The model predicts 95% of the study area to be potentially least suitable for S. alternifolium, whereas only 5% of the study area is predicted to be moderate to highly potentially suitable for the species. Furthermore, the model identified novel, potential habitats with similar ecological conditions that can be used as a guide for the introduction/reintroduction of S. alternifolium to expand its range and assist in species recovery from its endangered category.
Spiritualitas Generasi Muda di Gereja Kristen Pasundan Bakal Jemaat di Kampung Teko terhadap Tradisi Perayaan Etnis Tionghoa bagi Generasi Z dalam Konteks Budaya Populer
Authors: Matahelemual Maria Aprina 
Published: November 2022

AbstractThis article aims to provide an overview of the young generation spirituality of the church in interpreting various celebrations of Chinese traditions that are celebrated by the family and the community in the church. Various celebrations of Chinese traditions carried out by members of the congregation influence the dynamics of church ministry. However, the young generation of the church did not seem to reject the Chinese traditions but also did not show an accepting atitude or living the traditions as part of their spiritual life. As young generation they participate in various traditional ancestral with their parents and families as part of a respect to the parents with social interpretation which tradition as a social function that does not conflict with their Christian faith. Their spirituality of the tolerant and inclusive are built a wise action for church life in a plural society, especially providing a good influence on church life in the midst of the Western Javanese context as the scope of growth of the Pasundan Christian Church.
AbstrakArtikel ini bertujuan untuk memberikan gambaran spiritualitas generasi muda gereja masa kini dalam memaknai berbagai perayaan tradisi Tionghoa yang dipelihara baik oleh keluarga dan masyarakat di mana gereja bertumbuh. Beragam perayaan tradisi Tionghoa yang dilakukan oleh anggota jemaat memberikan pengaruh terhadap dinamika pelayanan gereja baik secara langsung maupun tidak langsung. Sekalipun demikian, generasi muda gereja terkesan tidak menolak terhadap tradisi perayaan etnis Tionghoa tetapi juga tidak menunjukkan sikap menerima dan menghayati perayaan tersebut sebagai bagian dari kehidupan spiritualitas mereka. Sebagai generasi muda gereja mereka turut serta dalam berbagai perayaan tradisionalleluhur bersama orang tua dan keluarga sebagai bagian dari bentuk hormat pada orang tua dan memaknai perayaan tersebut sebagai fungsi sosial yang tidak bertentangan dengan iman kristiani yang mereka miliki. Spiritualitas generasi muda yang toleran dan inklusif tersebut dipandang sangat membangun panggilan hidup bergereja di tengah masyarakat majemuk, terutama memberikan pengaruh baik bagi hidup bergereja di tengah konteks Jawa bagian Barat sebagai ruang lingkup pertumbuhan Gereja Kristen Pasundan.
Merayakan Imago Dei Bersama Orang dengan Disabilitas Intelektual dalam Cinta Persahabatan
Authors: Nainggolan Dina Maria 
Published: November 2022

AbstractThis article explores the spiritual dimensions of people with mild to severe intellectual disabilities. Dimensions that are increasingly lost and neglected, especially since the Enlightenment era which focuses to intellectuality and rationality as the summa of human existence. Human image with God has been understood only in terms of rational and intellectual abilities which leads to discrimination and neglect of God’s image in persons with disabilities, especially persons with intellectual disability. This article seeks to fi nd the image of persons with intellectual disabilities with God through the manifestation of love and shows that persons with intellectual disabilities like others can find God in Holy Spirit who works beyond human intellectual abilities.
AbstrakArtikel ini menelusuri dimensi spiritualitas penyandang disabilitas intelektual ringan hingga parah. Dimensi yang semakin hilang dan terabaikan terutama sejak abad pencerahan yang menekankan intelektualitas dan rasionalitas sebagai keberadaan manusia yang terutama. Kesegambaran manusia dengan Allah sejauh ini dipahami hanya dalam kemampuan rasional dan intelektual yang berujung pada diskriminasi dan pengabaian kesegambaran Allah dalam diri penyandang disabilitas terutama penyandang disabilitas intelektual. Tulisan iniberupaya untuk menemukan kesegambaran penyandang disabilitas intelektual dengan Allah melalui perwujudan hidup yang penuh cinta kasih dan menunjukkan bahwa penyandang disabilitas intelektual sama seperti mereka yang tidak menyandang disabilitas dapat menemukan Allah dalam kuasa Roh Kudus yang bekerja melampaui kemampuan intelektualitas manusia yang terbatas.