bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individualized precise scheduling strategy based on program’s runtime characteristic for workload consolidation
Authors: Wang Lin , Huang Tianyuan , Geng Shichao 
Published: July 2022

Abstract
In data centers, workload consolidation is the common method to improve resource utilization. However, efficient workload consolidation faces challenges from two aspects: the first is the wide variety of program characteristics; the second is the multiple performance indexes in clusters or data centers, such as the program performance requirement from custom and the system utilization from the cluster provider. In this paper, multiple experiments are executed about program performance with restricted resource usage, and four conclusions are summarized. Then based on the conclusions, two individualized precise scheduling strategies are proposed for efficient consolidation. Sche-index2 schedule programs by considering the resource sensitivity hyper-plane on five resource dimensions, and Sche-utility scheduling programs by considering the sensitivity curve of five resource dimensions. The experiment results show that compared with the common scheduling strategy, Sche-index2 can improve the average performance of the program by 36%, and Sche-utility can improve the average performance of the program by 27.6%. Meanwhile, both of the scheduling strategies can improve the resource utilization of CPU, disk read/write bandwidth, memory, and network bandwidth.
Simulation and evaluation method of loess subsidence based on model test
Authors: Wang Ping , Xu Shuya , Shao Shengjun , Wang Huijuan 
Published: July 2022

Abstract
Loess is characterized by high dynamic vulnerability due to its macro-porous and weakly cemented structure. Under the action of medium strong earthquake, it can induce earthquake subsidence, landslide, liquefaction, and other seismic geological disasters. （Zhang Z L，2016）The existing evaluation methods for earthquake subsidence are limited in scale simulation and seismic source simulation, leading to the deviation between the evaluation results and the actual situation. At the same time, the existing calculation method of seismic subsidence does not fully consider the structural environment factors, resulting in the deviation between the evaluation result and the actual situation, which is not conducive to reducing the construction cost. Therefore, it is urgent to improve the existing evaluation methods for earthquake subsidence. Developed a device to simulate the overburden pressure of the soil layer, and the model test of loess subsidence under strong earthquake was carried out in this study. The result of research shows that（1）The overburden pressure device can simulate the consolidation of soil at different depths and effectively reduce the boundary effect.（2）Axial deformation is the result of horizontal shear stress and vertical compression stress. Under the simultaneous amplification effect of upper earthquake, the soil subjected to shear damage is cracked. （3）Compared with the triaxial evaluation results, the evaluation results of shaking table test can provide a theoretical basis for correcting the phenomenon that the evaluation result of dynamic triaxial test is 1/3 larger than that of model test.
Experimental and analytical investigation into age-dependent properties of recycled coarse aggregate and bottom ash concrete
Authors: Saxena Ashray , Sulaiman Syed Sarosh , Shariq Mohd , Ansari Mohd Asif 
Published: July 2022

Abstract
This paper addresses the age-dependent concrete properties using recycled coarse aggregate (RCA), coal bottom ash (BA), and their combination. The RCA was prepared from the concrete blocks procured from the demolished concrete building. The RCA was used partially and fully to replace crushed rock aggregate to prepare RCA concrete. The thermal power plant BA was used partially and fully for fine aggregate replacement in RCA concrete. Firstly, the collected concrete boulders were crushed to the required RCA sizes and sieved as per the recommended standards. Then, the mix design of RCA and BA concrete of M25 grade was carried out based on the trial method. The intrinsic and surface quality of concrete was also checked using pulse velocity and rebound hammer for all concrete mixes. The mechanical properties of RCA, BA, and RCA + BA concrete are compared with the properties of conventional concrete and found in the acceptable range. The experimental results are justified with the help of microstructural analysis through scanning electron microscopy (SEM). The analytical models for predicting age-dependent compressive strength, splitting tensile strength, and static elastic modulus of RCA, BA, and RCA + BA concrete have been proposed. The analytical models for predicting the above mechanical properties of RCA, BA, and RCA + BA concrete using UPV and RHN at any age have also been suggested. The analytical models can be applied to the existing concrete industries to assess the health of buildings, where buildings are built with RCA, BA, and their combination. The present research will also contribute to sustainable development.
Determinants of outflow rate during flexible ureteroscopy: an experimental in vivo study in an anesthetized porcine model
Authors: Faria-Costa Gabriel , Tsaturyan Arman , Peteinaris Angelis , Faitatziadis Solon , Liatsikos Evangelos , Kallidonis Panagiotis 
Published: July 2022

Abstract
Purpose: To evaluate the effect of different ureteroscope positions, saline pumping frequency, laser fiber diameter and ureteral access sheath (UAS) on outflow rate during flexible ureteroscopy (fURS). Material and Methods: This study was performed in an anesthetized porcine model. The fURS setup included a manual pumping system, a 9.5Fr single used-digital flexible ureteroscope and a ureteral access sheath (UAS). Outflow was collected and measured from the UAS during 1 minute in all experimental settings. The evaluated variables were the position of the ureteroscope, the pumping frequency (2s, 3s or 5s), the diameter of the used UAS (12/14Fr or 14/16Fr) and laser fiber (200 μm or a 272 μm). Results: Ureteroscope position in the lower calyx was associated with significantly lower outflow rate (p<0.05). The use of the 14/16Fr UAS resulted in improved flow in the renal pelvis and upper calyx (p<0.05) but not in the lower calyx. The use of a 200 μm laser fiber only improved flow in the upper calyx and when a 14/16Fr UAS was being used.Pumping frequency did not show a significant correlation with outflow rate.Conclusions: The ureteroscope positioning and UAS size were important determinants of outflow rate during fURS, while laser fiber diameter had a limited effect. In the lower calyx the outflow was minimal and was not improved by using a larger UAS.
Investigation of railway track subsidence based on Electrical Resistivity Tomography (ERT) and Sensitivity analysis
Authors: Rupesh Rupesh , Tiwari Prarabdh , Sharma Shashi Prakash 
Published: July 2022

Abstract
Subsidence of ground is a common global problem. Several environmental and ecological destructions can observe due to subsidence. The present geophysical study includes investigating the subsidence of railway tracks in Salanpur, Paschim Bardhaman district, West Bengal (India). Electrical Resistivity Tomography (E.R.T.), an advanced geophysical method, has been applied to locate and delineate subsurface cavities mainly responsible for subsidence. ABEM-Terrameter LS-2 instrument incorporated for data acquisition with the prospecting techniques of Wenner, Wenner-Schlumberger, Dipole-dipole, and Gradient array. The generated forward model using the Res2dmod algorithm includes hollow and filled cavities to simulate the subsurface response. 2D inversion and sensitivity analysis was carried out through the Res2dinv program based on a smoothness constrained regularized least-square optimization procedure for different electrode configurations. E.R.T. survey has shown its proficiency in detecting various cavities and unstable subsurface zone responsible for railway track subsidence. The present research paper could help to locate subsidence-prone zones in different areas.
Digital twins of nonlinear dynamical systems
Authors: Kong Ling-Wei , Weng Yang , Glaz Bryan , Haile Mulugeta , Lai Ying-Cheng 
Published: July 2022

Abstract
We articulate the design imperatives for machine-learning based digital twins for nonlinear dynamical systems subject to external driving, which can be used to monitor the ``health'' of the target system and anticipate its future collapse. We demonstrate that, with single or parallel reservoir computing configurations, the digital twins are capable of challenging forecasting and monitoring tasks. Employing prototypical systems from climate, optics and ecology, we show that the digital twins can extrapolate the dynamics of the target system to certain parameter regimes never experienced before, make continual forecasting/monitoring with sparse real-time updates under nonstationary external driving, infer hidden variables and accurately predict their dynamical evolution, adapt to different forms of external driving, and extrapolate the global bifurcation behaviors to systems of some different sizes. These features make our digital twins appealing in significant applications such as monitoring the health of critical systems and forecasting their potential collapse induced by environmental changes.
Frequency of Virulence Genes and Their Association with Biofilm Formation Ability in Klebsiella pneumoniae Isolated from Wound Infections
Authors: Kelishomi Fatemeh Zeynali , Amereh Samira , Ghayyaz Fatemeh , Javadi Amir , Anari Raana Kazemzadeh , Nikkhahi Farhad 
Published: July 2022

Abstract
In recent years, the prevalence of Klebsiella pneumoniae in wound infections has been increasing. The current study aimed to evaluate the biofilm formation capacity of wound-related K. pneumoniae isolates and to find a possible association between the presence of virulence genes and biofilm formation. A total of 74 K. pneumoniae isolates were collected from wound site infections. Molecular studies were performed to confirm the presence of fimH, mrkD, mrkA, wcaG, magA, entB, and irp2 genes. Biofilm formation was determined by microtiter plate assay. All of the tested isolates were able to produce biofilm structure. The frequency of entB, fimH, mrkD, mrkA, wcaG, irp2, and magA was 95.9%, 94.6%, 90.5%, 75.7%, 55.4%, 50%, and 9.5%, respectively. The statistical analysis proved that there was a significant association between biofilm production, presence of fimH, mrkD, mrkA, and wcaG genes and resistance to cephalosporins, amikacin, and trimethoprim/sulfamethoxazole (P < 0.05).
An Approximate Travel Time Calculation and a Robust GNSS-Acoustic Positioning Method Using a MCMC technique
Authors: Tomita Fumiaki , Kido Motoyuki 
Published: July 2022

Abstract
It is important to consider horizontal heterogeneity in an underwater sound speed structure to accurately estimate positions of GNSS-acoustic sites. Although large amounts of moving survey data (a sea-surface platform moves around when acoustic signals are transmitted) are required to accurately detect a sloping sound speed structure, the actual observational data do not necessarily include sufficient moving survey data due to sea conditions or observational time. To treat these insufficient data, it was assumed that a shallow sound speed gradient was continuously present up to a fixed water depth (gradient depth). However, the validity of this assumption has not been investigated, and the gradient depth has not been optimized. In this study, we developed a new GNSS-acoustic array positioning method that optimizes the gradient depth using an MCMC technique. To employ this technique, we also developed an approximate technique for rapidly calculating travel time because the conventional travel-time calculation requires high computational cost for integration into the MCMC technique. We assessed the performance of the approximate travel time calculation technique and demonstrated its sufficient accuracy and precision for estimating array positions. Then, we applied the new GNSS-acoustic array positioning method to the actual observational data collected by the Japan Coast Guard and Tohoku University. Using enough amounts of the moving survey data, our method demonstrated the results comparable with the conventional GNSS-acoustic positioning method estimating a sloping sound speed structure; thus, the assumption of the sound speed gradient with the fixed water depth was valid. Moreover, due to the physical restriction of this assumption, our method provided robust solutions even when the observational data contained small quantities of moving survey data with a simple sea-surface track. Although our method still cannot be used in the scenario where no moving survey data are available, it can work robustly compared with the conventional method.
Interleukin-17A promotes proliferation and osteogenic differentiation of human ligamentum flavum cells through regulation of β-catenin nuclear translocation
Authors: Lin Jialiang , Jiang Shuai , Xiang Qian , Zhao Yongzhao , Wang Longjie , Fan Dongwei , Zhong Woquan , Sun Chuiguo , Chen Zhongqiang , Li Weishi 
Published: July 2022

Abstract
Thoracic ossification of the ligamentum flavum (TOLF) is the leading cause of thoracic spinal stenosis with no specifc treatment available. IL-17A has received widespread attention for its key contribution in the regulation of bone metabolism and heterotopic ossification. However, it is unclear whether IL-17A is involved in TOLF. Our results showed that IL-17A expression was elevated in ossified ligamentum flavum tissue compared to normal ligamentum flavum. In in vitro experiments, IL-17A stimulation promoted the proliferation and osteogenic differentiation of ligamentum flavum cells (LFCs) derived from TOLF patients. Mechanistically, we found that IL-17A stimulation promoted nuclear translocation of β-catenin, whereas silencing of β-catenin attenuated IL-17A-induced proliferation and osteogenic differentiation of LFCs. Furthermore, co-culture of T helper 17 (Th17) cells with LFCs showed that IL-17A secreted by Th17 cells significantly enhanced the accumulation of β-catenin in the nucleus, as well as the proliferation and osteogenic differentiation of LFCs. However, these effects were markedly attenuated after the neutralization of IL-17A. Our study demonstrates that IL-17A secreted by Th17 cells in the lesion microenvironment may be involved in TOLF by regulating nuclear translocation of β-catenin to promote proliferation and osteogenic differentiation of LFCs. This study helps to elucidate the pathological mechanism of TOLF and suggests the possibility of IL-17A as a potential target for the prevention and treatment of TOLF.
Expression of S100A8 protein on B cells is associated with disease activity in patients with systemic lupus erythematosus
Authors: Kitagori Koji , Oku Takuma , Wakabayashi Masaki , Nakashima Ran , Murakami Kosaku , Hirayama Yoshitaka , Ishihama Yasushi , Ohmura Koichiro , Morinobu Akio , Mimori Tsuneyo , Yoshifuji Hajime 
Published: July 2022

Abstract
Background
Systemic lupus erythematosus (SLE) is an intractable disease characterized by autoantibody production and autoreactive B and T cell proliferation. Although several studies have revealed multiple genetic and environmental associations, the underlying mechanisms remain unknown.
Methods
We performed proteomics and transcriptomics using liquid chromatography-mass spectrometry and DNA microarray, using peripheral blood B cells from patients with SLE, and explored molecules associated with the pathophysiology of SLE.
Results
We identified for the first time that expression of both S100A8 protein and mRNA were markedly upregulated in SLE B cells. The results obtained using flow cytometry showed that S100A8 was highly expressed on the surface of B cells of patients with active SLE, and S100A8 on the cell surface was decreased after treatment; therefore, it is suggested that S100A8 may be a marker for disease activity. The mRNA expression of S100A8 was particularly upregulated in memory B cells, suggesting that S100A8 may be mainly secreted by memory B cells in the pathogenesis of SLE.
Conclusions
Our results imply that the S100A8 proteins secreted from memory B cells may stimulate granulocytes and monocytes through pattern recognition receptors, activate the innate immune system, and are involved in the pathogenesis of SLE.
Cross-sectional study for derivation of a cut-off value for identification of a timely versus late diagnosis of endometriosis based on analytical and descriptive research methods
Authors: Brandes Iris , Kleine-Budde Katja , Heinze Nicole , Binder Sebastian , Klug Constanze , Schippert Cordula , Ebert Andreas D. , Halis Gülden 
Published: July 2022

Abstract
BackgroundEndometriosis is a benign, hormone-dependent, chronic inflammatory gynecological disease accompanied by cyclic and acyclic pelvic pain and other complaints. The long lists of research recommendations in the AWMF guideline [5] and ESHRE Endometriosis Guideline [6] show that there is still a great need for research in all aspects of the disease. Diagnostic delay, defined as the mean time between symptom onset and confirmed diagnosis, is a particular problem associated with endometriosis. Some quantitative and qualitative studies have investigated possible reasons for this. A range of physician-related [7, 8] and patient-related factors [9] as well as stigmatization of the topic of menstruation by society have been identified [10, 11]. The consequences of the disease being diagnosed late (or too late) on the course of disease, the quality of life and the costs of the disease have already been documented in studies [12, 13]. However, a systematically derived cut-off value that clearly distinguishes between short and long delay is still lacking. Therefore, the aim of our study was to derive a threshold value for the definition of a target corridor for endometriosis diagnosis based on descriptive and analytical methods.MethodsSince our review of the rather sparse publications on diagnostic delay did not yield satisfactory results, we used descriptive statistics and location parameters to calculate a cut-off value for German population data from the EndoCost study. Statistical methods were used for correlation analysis of shortDD versus longDD (correlation analysis and logistic regression) and group membership (discriminant analysis). ResultsFive years was identified as the cut-off value that significantly differentiated between shortDD and longDD based on various disease-related variables. This suggests that endometriosis should be definitively diagnosed within less than five years to minimize the risk of an unfavorable course of the disease. Our findings confirmed that an early onset of endometriosis-related symptoms is the most important risk factor for a long diagnostic delay. Consequently, adolescent females should receive increased attention as an especially vulnerable group. Evidently, there is an urgent need to develop adequate concepts to improve the endometriosis education and care among this target group.
Faecal egg counts and bulk milk Anti-O. ostertagi antibody testing in pasture based dairy cattle of Victoria, Australia
Authors: Loughnan Tom , Mansell Peter , Beggs David 
Published: July 2022

Abstract
Background:International research has suggested that anti Ostertagia ostertagi antibody optical density ratio (ODR) of vat milk can indicate the level of milk production benefit producers will get from applying effective anthelmintic treatments to lactating dairy cows. ODR is an indirect antibody ELISA assessment of the magnitude of antibody production specific to O. ostertagi. In Australian pastoral dairy systems, the worm challenge season can be prolonged with high rainfall temperate climates where lactating cattle and young stock are grazing year-round. The objective of this study was to look for a correlation between ODR and faecal egg count (FEC) or the presence of parasite eggs in faeces in corresponding cohorts.Methods:Fourteen commercial dairy herds in south-west Victoria (Australia) were sampled in the study. Faecal samples were collected from recently calved cows (less than 30 days in milk) for individual FEC (sensitive to 2.5 eggs per gram of faeces) Fifteen primiparous and 15 multiparous animals of representative ages were sampled. On the same day, milk vat samples were collected during the calving period for ODR. Farm management practices including recent and routine anthelmintic use was recorded for each property and each cohort of animals.Results:Bulk milk ODR was not related to measurable FEC in corresponding herds. Bulk milk ODR was also not related to the proportion of animals in each corresponding cohort with detected parasite eggs in faeces. Bulk milk ODR was strongly correlated with days since most recent anthelmintic application (r2=0.73).Conclusion:Anti-O. ostertagi ODR is a good measure of likely antibody presence against O. ostertagi. However, in pastoral systems in Australia where worms are present on pasture for sustained periods, possibly year-round, it may not be a good measure of current parasite load. ODR should not be used as the sole determinant of anthelmintic application in Victorian pastoral dairy herds.
Sulfated galactofucan from Sargassum thunbergii Attenuates atherosclerosis by suppressing inflammation via TLR4/MyD88/NF-κB Signaling Pathway
Authors: Zhu Ke-fu , Wang Xi-hao , Weng Ying-zheng , Mao Gen-xiang , Bao Yi-zhong , Lou Jiang-jie , Wu Shao-ze , Jin Wei-hua , Tang Lijiang 
Published: July 2022

Abstract
Purpose: Sulfated galactofucan (SWZ-4), which was extracted from Sargassum thunbergii, has recently been reported to have anti-inflammatory and anti-cancer property. The present study aimed to evaluate if SWZ-4 could attenuate atherosclerosis in Apolipoprotein E-deficient (ApoE KO) mice by suppressing inflammatory response through TLR4/MyD88/NF-κB signaling pathway.Methods: Male ApoE KO mice were fed with high-fat diet for 16 weeks and intraperitoneally injected with SWZ-4. RAW246.7 cells were treated with lipopolysaccharide (LPS) and SWZ-4. Atherosclerotic lesions were measured by Sudan IV and Oil Red O staining. Serum lipid profiles, inflammatory cytokines, and mRNA and protein expression levels were evaluated.Results: SWZ-4 decreased serum TNF-α, IL-6 and IL-1 levels, but cannot improve blood lipid profiles. SWZ-4 downregulated the mRNA and protein expression of TLR4, MyD88 and phosphorylation of p65 and attenuated atherosclerosis in the ApoE KO mice (P < 0.01). In LPS-stimulated RAW 264.7 cells, SWZ-4 inhibited pro-inflammatory cytokines and the mRNA expression of TLR4, MyD88 and p65 and reduced the proteins expression of TLR4, MyD88 and the phosphorylation of p65 (P < 0.01).Conclusion: These results suggest that SWZ-4 exerts an anti-inflammatory effect in ApoE KO atherosclerosis mice via inhibiting TLR4/MyD88/NF-κB signaling pathway in macrophages, and may potentially serve as a treatment for atherosclerosis.