bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prostate cancer therapy personalization via multi-modal deep learning on randomized phase III clinical trials
Authors: Esteva Andre , Feng Jean , van der Wal Douwe , Huang Shih-Cheng , Simko Jeffry P. , DeVries Sandy , Chen Emmalyn , Schaeffer Edward M. , Morgan Todd M. , Sun Yilun , Ghorbani Amirata , Naik Nikhil , Nathawani Dhruv , Socher Richard , Michalski Jeff M. , Roach Mack , Pisansky Thomas M. , Monson Jedidiah M. , Naz Farah , Wallace James , Ferguson Michelle J. , Bahary Jean-Paul , Zou James , Lungren Matthew , Yeung Serena , Ross Ashley E. ,   NRG Prostate Cancer AI Consortium, Kucharczyk Michael , Souhami Luis , Ballas Leslie , Peters Christopher A. , Liu Sandy , Balogh Alexander G. , Randolph-Jackson Pamela D. , Schwartz David L. , Girvigian Michael R. , Saito Naoyuki G. , Raben Adam , Rabinovitch Rachel A. , Katato Khalil , Sandler Howard M. , Tran Phuoc T. , Spratt Daniel E. , Pugh Stephanie , Feng Felix Y. , Mohamad Osama 
Published: June 2022

AbstractProstate cancer is the most frequent cancer in men and a leading cause of cancer death. Determining a patient’s optimal therapy is a challenge, where oncologists must select a therapy with the highest likelihood of success and the lowest likelihood of toxicity. International standards for prognostication rely on non-specific and semi-quantitative tools, commonly leading to over- and under-treatment. Tissue-based molecular biomarkers have attempted to address this, but most have limited validation in prospective randomized trials and expensive processing costs, posing substantial barriers to widespread adoption. There remains a significant need for accurate and scalable tools to support therapy personalization. Here we demonstrate prostate cancer therapy personalization by predicting long-term, clinically relevant outcomes using a multimodal deep learning architecture and train models using clinical data and digital histopathology from prostate biopsies. We train and validate models using five phase III randomized trials conducted across hundreds of clinical centers. Histopathological data was available for 5654 of 7764 randomized patients (71%) with a median follow-up of 11.4 years. Compared to the most common risk-stratification tool—risk groups developed by the National Cancer Center Network (NCCN)—our models have superior discriminatory performance across all endpoints, ranging from 9.2% to 14.6% relative improvement in a held-out validation set. This artificial intelligence-based tool improves prognostication over standard tools and allows oncologists to computationally predict the likeliest outcomes of specific patients to determine optimal treatment. Outfitted with digital scanners and internet access, any clinic could offer such capabilities, enabling global access to therapy personalization.
Jolkinolide B induces cell cycle arrest and apoptosis in MKN45 gastric cancer cells and inhibits xenograft tumor growth in vivo
Authors: Zhang Hao , Qian Jiayi , Jin Ming , Fan Li , Fan SongJie , Pan Hong , Li Yang , Wang Ningning , Jian Baiyu 
Published: June 2022

Abstract
Gastric cancer is one of the most common digestive carcinomas throughout the world and represents high mortality. There is an urgent quest for seeking a novel and efficient antigastric cancer drug. Euphorbia fischeriana Steud had long been used as a traditional Chinese medicine for the treatment of cancer. According to the basic theory of traditional Chinese medicine, its antitumor mechanism is ‘to combat poison with poison’. However, its effective material foundation of it is still ambiguous. In our previous work, we studied the chemical constituents of E. fischeriana Steud. Jolkinolide B (JB) is an ent-abietane-type diterpenoid we isolated from it. The purpose of the present study was to investigate the antigastric effect and mechanism of JB. Results revealed that JB could suppress the proliferation of MKN45 cells in vitro and inhibit MKN45 xenograft tumor growth in nude mice in vivo. We further investigated its anticancer mechanism. On the one hand, JB caused DNA damage in gastric cancer MKN45 cells and induced the S cycle arrest by activating the ATR-CHK1-CDC25A-Cdk2 signaling pathway, On the other hand, JB induced MKN45 cells apoptosis through the mitochondrial pathway, and ultimately effectively inhibited the growth of gastric cancer cells. These results suggest that JB appears to be a promising candidate drug with antigastric cancer activity and warrants further research.
Treatment Limitations for Pediatric Diffuse Intrinsic Pontine Gliomas in a Middle-Income Country
Authors: Baquero-Herrera Pablo E. , Ardila-Martínez Manuel A. , Abdalá-Vargas Nadín J. , Racedo Jorge , Ordóñez-Rubiano Edgar G. 
Published: June 2022

Abstract

Objectives To evaluate the surgical management outcomes in pediatric patients with diffuse intrinsic pontine gliomas (DIPGs) who underwent intended biopsies and partial resections in a middle-income country, highlighting the barriers and challenges of these procedures for further investigation.

Methods A retrospective review of a prospective acquired series of patients who underwent biopsy or resection for DIPG between January 2012 and June 2018 at our institution was performed.

Results A total of 43 patients with posterior fossa tumors were identified. From these, seven pediatric DIPG cases were enrolled. Five were males. The median age was 5 years (range: 1–12 years). Only one patient (14.3%) had a ganglioglioma, while the others presented pilocytic and diffuse astrocytomas. Two (28.6%) patients had an intentional biopsy, and the other five (71.4%) had a partial resection. In the three (28.6%) patients who presented with associated hydrocephalus, the endoscopic third ventriculostomy was performed in the same surgical time. The median preoperative Lansky play-performance scale (LPPS) was 80 (range: 60–100), while the median postoperative LPPS was 23 (range: 7–52).

Conclusion A decrease in overall survival was noted compared with data reported in other series. Multifactorial barriers were discussed including the social, geographic, and economic features that may influence on final outcomes.
Association between Parent-Reported Executive Functions and Self-Reported Emotional Problems among Adolescent Offspring of Fathers with Alcohol-Dependence
Authors: Nattala Prasanthi , Kishore M. Thomas , Murthy Pratima , Christopher Rita , Veerabathini Jessy Sharon , Suresh Sumegha 
Published: June 2022

Abstract

Objectives To compare the executive functions in adolescents of fathers with alcohol dependence (AOFADs) with a control group of adolescents without a paternal history of alcohol dependence and examine the association between executive functioning problems and behavioral and emotional problems.

Materials and Methods The study included 39 AOFADs and 45 adolescent offspring of fathers without a history of alcohol-use disorders, who were matched for age and sex. They were assessed using standardized measures of executive functions and emotional and behavioral problems.

Statistical Analysis A comparison was made between the two groups about the parental report of adolescents' executive functions and adolescents' self-reported emotional and behavioral problems. ANCOVA was performed to understand the covariance of educational and socio-economic status on executive functions. Correlation between executive functions, emotional and behavioral problems, and the duration of father's alcohol dependence was examined with Spearman's rho.

Results AOFAD group showed significant impairment on all subdomains of executive functions and emotional and behavioral disturbances (p < 0.01) but not on the prosocial behavioral dimension (p < 0.01). The group differences were independent of child's education and family income. Executive functional impairments positively correlated with psychopathology (p < 0.01). Problems with executive functions and psychopathology correlated with the duration of the father's alcohol dependence.

Conclusions AOFADs are at risk for executive function impairments which in turn are strongly associated with emotional and behavioral problems. The association is independent of child's education and family economic status. The duration of alcohol dependence in fathers is associated with these problems. It has implications for targeted interventions for both adolescents and families.
Novel Technologies in Chronic Wound Care
Authors: Hayun Yehiel , Yaacobi Dafna Shilo , Shachar Tal , Harats Moti , Grush Andrew E. , Olshinka Asaf 
Published: June 2022

AbstractIn Israel, 20% of wounds do not progress to full healing under treatment with conservative technologies of which 1 to 2% are eventually defined as chronic wounds. Chronic wounds are a complex health burden for patients and pose considerable therapeutic and budgetary burden on health systems. The causes of chronic wounds include systemic and local factors. Initial treatment involves the usual therapeutic means, but as healing does not progress, more advanced therapeutic technologies are used. Undoubtedly, advanced means, such as negative pressure systems, and advanced technologies, such as oxygen systems and micrografts, have vastly improved the treatment of chronic wounds. Our service specializes in treating ulcers and difficult-to-heal wounds while providing a multiprofessional medical response. Herein, we present our experience and protocols in treating chronic wounds using a variety of advanced dressings and technologies.
A compact transparent polarization-insensitive metasurface with broadband monostatic and bistatic radar cross-section reduction of millimeter-waves
Authors: He Xiaoluo , Qi Chu , Wong Alex M H 
Published: June 2022

Abstract
This paper proposes an optimized optically transparent metasurface (OTM) which achieves broadband monostatic and bistatic radar cross-section (RCS) reduction with polarization and angle insensitivity. Through employing (a) theoretical formulation involving both monostatic and bistatic RCS and (b) unit cell placement optimization using the particle swarm optimization approach, we achieve monostatic and bistatic RCS reduction over a broad bandwidth with a single-layer, ultra-thin metasurface featuring only two types of unit cells. The proposed metasurface has high optical transparency and electrically small size compared to counterparts with similar performances. Simulation and experimental measurement show that the metasurface achieves more than 10 dB monostatic and bistatic RCS reduction from 18 to 34 GHz, which completely covers the 5G mm-wave spectrum. The proposed optically transparent metasurface can find use in many areas, including mm-wave applications, invisible glass technology, and vehicle windshield systems.
Superfluid density in conventional superconductors: from clean to strongly disordered
Authors: Dutta Surajit , Raychaudhuri Pratap , Mandal Sudhansu S , Ramakrishnan T V 
Published: June 2022

Abstract
The highly convergent form of superfluid density in disordered conventional superconductors available in the literature and independently obtained by us following the approach of an earlier paper (Mandal and Ramakrishnan 2020 Phys. Rev. B 102 024514) has been reformulated to separate out the generally used so-called ‘dirty-limit’ term and an additional term. We use this new expression for making an extensive comparison with previously published experimental data and show that the former, generally used, term is not sufficient for analyzing these results. We point out that consequently, there is a large regime (disordered superconductors with moderate to no disorder) where theoretical predictions need to be confronted with experiment.
Magnetoresistance studies of two-dimensional Fe3GeTe2 nano-flake
Authors: Zeng Xiangyu , Ye Ge , Huang Shuyi , Zhang Liang , Xu Hongsheng , Liu Yulu , Kuang Haoze , Ma Boyang , Luo Jikui , Lu Xin , Wang Xiaozhi 
Published: June 2022

Abstract
The magneto-transport properties of two-dimensional (2D) Fe3GeTe2 (FGT) nano-flakes are carefully investigated with the variation of the temperature and the direction of the applied magnetic field (B). Four magnetoresistance (MR) behavior are obtained at different temperatures with B paralleling the flake’s surface, because of the competition between the merging of different domains, spin fluctuation, and the spin momentum flipping. Different from the reported negative MR of bulk FGT, 2D FGT shows a positive MR behavior with the increase of B at a low temperature in a low B range, owning to the domination of the spin momentum flipping induced by the weakening of the coupling between different layers with the decrease of the thickness of the FGT flake. The angle-dependence of the FGT MR is also investigated and can be well explained by the competition mentioned above.
Quenched Poisson processes for random subshifts of finite type
Authors: Crimmins Harry , Saussol Benoît 
Published: June 2022

Abstract
In this paper we study the quenched distributions of hitting times for a class of random dynamical systems. We prove that hitting times to dynamically defined cylinders converge to a Poisson point process under the law of random equivariant measures with super-polynomial decay of correlations. In particular, we apply our results to uniformly aperiodic random subshifts of finite type equipped with random invariant Gibbs measures. We emphasize that we make no assumptions about the mixing property of the marginal measure.
Global hypersurfaces of section in the spatial restricted three-body problem
Authors: Moreno Agustin , van Koert Otto 
Published: June 2022

Abstract
We propose a contact-topological approach to the spatial circular restricted three-body problem, for energies below and slightly above the first critical energy value. We prove the existence of a circle family of global hypersurfaces of section for the regularized dynamics. Below the first critical value, these hypersurfaces are diffeomorphic to the unit disk cotangent bundle of the two-sphere, and they carry symplectic forms on their interior, which are each deformation equivalent to the standard symplectic form. The boundary of the global hypersurface of section is an invariant set for the regularized dynamics that is equal to a level set of the Hamiltonian describing the regularized planar problem. The first return map is Hamiltonian, and restricts to the boundary as the time-1 map of a positive reparameterization of the Reeb flow in the planar problem. This construction holds for any choice of mass ratio, and is therefore non-perturbative. We illustrate the technique in the completely integrable case of the rotating Kepler problem, where the return map can be studied explicitly.
Entropy inequalities for semigroup actions
Authors: Carvalho Maria , Rodrigues Fagner B , Varandas Paulo 
Published: June 2022

Abstract
We extend Margulis–Ruelle inequality to the general setting of semigroup actions which are finitely generated either by Lipschitz continuous maps acting on a compact metric space or by smooth maps on a compact Riemannian manifold. We also discuss a few examples to illustrate the sharpness of our estimates.
Geometric graph-theoretic aspects of quantum stabilizer codes
Authors: Cafaro Carlo 
Published: June 2022

Abstract
We propose a systematic procedure for the construction of graphs associated with binary quantum stabilizer codes. The procedure is characterized by means of the following three step process. First, the stabilizer code is realized as a codeword-stabilized (CWS) quantum code. Second, the canonical form of the CWS code is determined and third, the input vertices are attached to the graphs. In order to verify the effectiveness of the procedure, we implement the Gottesman stabilizer code characterized by multi-qubit encoding operators for the resource-efficient error correction of arbitrary single-qubit errors. Finally, the error-correcting capabilities of the Gottesman eight-qubit quantum stabilizer code is verified in graph-theoretic terms as originally advocated by Schlingemann and Werner.
Search for a signature of Pauli exclusion principle violation by VIP-2
Authors: De Paolis L , Napolitano F , Bartalucci S , Bazzi M , Bertolucci S , Bragadireanu M , Capoccia C , Cargnelli M , Clozza A , Del Grande R , Fiorini C , Guaraldo C , Iliescu M , Laubenstein M , Marton J , Miliucci M , Milotti E , Piscicchia K , Porcelli A , Scordo A , Shi H , Sirghi D L , Sirghi F , Sgaramella F , Zmeskal J , Curceanu C 
Published: June 2022

Abstract
The VIP-2 experiment performs a high sensitivity test of the Pauli Exclusion Principle for electrons, and is operated in the ultra-low cosmic background environment of the Gran Sasso Underground Laboratories of INFN. The experimental technique consists in testing the symmetry state of an open, continuously supplied, system of fermions; thus representing the only spin-statistics test which strictly fulfills the Messiah-Greenberg superselection rule. In April 2019, VIP-2 started the ongoing data taking campaign in its final layout, with the goal to improve the previous VIP result of at least two orders of magnitude. Before April 2019, VIP-2 collected, in a partial configuration of the external shielding complex, two sets of data in 2018–2019 for a total duration of about 208 days. We present in this work the results of the analyses of the first two data sets collected by VIP-2, which already improve the VIP result by one order of magnitude. The results are also interpreted in the framework of a diffusion random walk model, which provides a significantly enhanced description of the electrons-atoms close encounters process, and hence a boost on the estimated limit on the Pauli Exclusion Principle violation probability.
First-principles insights into thermoelectric properties of topological nontrivial semimetal LiAuTe material
Authors: Kara Ilham , Meghoufel Zahira Faïza , Menad Abdelkader , Cherifi Fatiha , Boukra AbdelAziz 
Published: June 2022

Abstract
Structural, electronic and thermoelectric properties of LiAuTe ternary compound are studied using density functional theory (DFT) and semi-classical Boltzmann transport theory. The cubic

α

-phase (space group F

4
¯

3m) is predicted to be ground state structure with a significant energy difference compared to honeycomb structure (space group P63mmc). The mechanical and dynamical stability of the

α

-phase is confirmed by calculating the elastic constants and phonon dispersion frequencies. At equilibrium lattice, with and without spin–orbit coupling, the LiAuTe compound band structure calculations show an s-p band inversion at Γ point, leading to a topological nontrivial semimetal phase. Thermoelectric parameters, such as Seebeck coefficient (S), electrical conductivity (σ), electronic (κ

e
) and lattice (κ

L
) thermal conductivities are computed. Electrons and holes relaxation times (τ) are also predicted. Hence, LiAuTe compound exhibits a low κ

L
value of 1.76 W mK−1 at room temperature which decreases with temperature increasing. At 900 K, κ

L
falls to 0.58 W mK−1 leading to a maximum ZT value of 0.52 at optimized n-doping concentration of 2.5 × 1020 cm−3. The present study reveals that LiAuTe compound is a suitable candidate for thermoelectric applications and will open new horizons for further researches on similar types of topological thermoelectric materials with better ZT.
PT challenge: validation of ShapeFit on large-volume, high-resolution mocks
Authors: Brieden Samuel , Gil-Marín Héctor , Verde Licia 
Published: June 2022

Abstract
The ShapeFit compression method has been shown to be a powerful tool to gain cosmological information from galaxy power spectra in an effective, model-independent way. Here we present its performance on the blind PT challenge mock products presented in [1]. Choosing a set-up similar to that of other participants to the blind challenge we obtained Δln(1010
As
) = -0.018 ± 0.014, ΔΩm = 0.0039 ± 0.0021 and Δh = -0.0009 ± 0.0034, remaining below 2σ deviations for a volume of 566 [h -1Gpc]3. This corresponds to a volume 10 times larger than the volume probed by future galaxy surveys. We also present an analysis of these mocks oriented towards an actual data analysis using the full redshift evolution, using all three redshift bins z
1 = 0.38, z
2 = 0.51, and z
3 = 0.61, and exploring different set-ups to quantify the impact of choices or assumptions on noise, bias, scale range, etc. We find consistency across reasonable changes in set-up and across redshifts and that, as expected, mapping the redshift evolution of clustering helps constraining cosmological parameters within a given model.
Isotropy statistics of CMB hot and cold spots
Authors: Khan Md Ishaque , Saha Rajib 
Published: June 2022

Abstract
Statistical Isotropy of the Cosmic Microwave Background (CMB) radiation has been studied and debated extensively in recent years. Under this assumption, the hot spots and cold spots of the CMB are expected to be uniformly distributed over a 2-sphere. We use the orientation matrix, first proposed by Watson (1965) and Scheidegger (1965) and associated shape and strength parameters (Woodcock, 1977) to analyse whether the hot and cold spots of the observed CMB temperature anisotropy field are uniformly placed. We demonstrate the usefulness of our estimators by using simulated toy models containing non-uniform data. We apply our method on several foreground minimized CMB maps observed by WMAP and Planck over large angular scales. The shape and strength parameters constrain geometric features of possible deviations from uniformity (isotropy) and the power of the anomalous signal. We find that distributions of hot or cold spots in cleaned maps show no unusual signature of clustering or girdling. Instead, we notice a strikingly uniform distribution of hot spots over the full sky. The signal remains robust with respect to the four cleaned maps used and presence or absence of the non-Gaussian cold spot (NGCS). On the partial sky with WMAP KQ75 and Planck U73 masks we find anomalously low strength of non-uniformity for cold spots which is found to be robust with respect to various cleaning methods, masks applied, instruments, frequencies, and the presence or absence of the NGCS. Interestingly we find that the signal of anomalously weak non-uniformity could be due to contributions from the quadrupole and octupole and may be related with the low CMB temperature variance anomaly.
Spectral fluctuations in the interacting boson model*
Authors: Wu Yu-Qing , Teng Wei , Hou Xiao-Jie , Na Gui-Xiu , Zhang Yu , He Bing-Cheng , Luo Yan-An 
Published: June 2022

Abstract
The energy dependence of the spectral fluctuations in the interacting boson model (IBM) and its connections to the mean-field structures are analyzed by adopting two statistical measures: the nearest neighbor level spacing distribution

measuring the chaoticity (regularity) in energy spectra and the

statistics of Dyson and Metha measuring the spectral rigidity. Specifically, the statistical results as functions of the energy cutoff are determined for different dynamical scenarios, including the U(5)-SU(3) and SU(3)-O(6) transitions as well as those near the AW arc of regularity. We observe that most of the changes in spectral fluctuations are triggered near the stationary points of the classical potential, particularly for cases in the deformed region of the IBM phase diagram. Thus, the results justify the stationary point effects from the perspective of statistics. In addition, the approximate degeneracies in the

spectrum on the AW arc is also revealed from the statistical calculations.