bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single pixel imaging based on large capacity spatial multiplexing metasurface
Authors: Yan Jingxiao , Wang Yongtian , Liu Yin , Wei Qunshuo , Zhang Xue , Li Xin , Huang Lingling 
Published: May 2022

Abstract
Single pixel imaging as an alternative to traditional imaging methods, has attracted extensive attention in various research fields. Metasurfaces with subwavelength unit cells and compact footprint can be used as a substitute for traditional optical elements. In this work, we propose a single pixel imaging scheme based on metasurface composed of photon sieves, where spatial modulation is realized through shifting. Spatial multiplexing capability is demonstrated by this shifting mode, which can obtain more patterns in limited space and greatly increase the mask capacity. Benefited from the simple structure and easy manufacture of photon sieves, large capacity metasurface can be manufactured. Meanwhile, metasurfaces can simplify the single pixel imaging system, leading to the system miniaturization and integration. In addition, numerical and optical experiments prove that our proposal can operate at the range from the entire visible light to near-infrared light. Such scheme provides a new way for single pixel imaging and would be applied in microscopic imaging, dynamic imaging, hyperspectral imaging, and so on.
Toward automated prediction of sudden unexpected death in epilepsy
Authors: Gu Bin , Adeli Hojjat 
Published: May 2022

Abstract
Sudden unexpected death in epilepsy (SUDEP) is a devastating yet overlooked complication of epilepsy. The rare and complex nature of SUDEP makes it challenging to study. No prediction or prevention of SUDEP is currently available in a clinical setting. In the past decade, significant advances have been made in our knowledge of the pathophysiologic cascades that lead to SUDEP. In particular, studies of brain, heart, and respiratory functions in both human patients at the epilepsy monitoring unit and animal models during fatal seizures provide critical information to integrate computational tools for SUDEP prediction. The rapid advances in automated seizure detection and prediction algorithms provide a fundamental framework for their adaption in predicting SUDEP. If a SUDEP can be predicted, then there will be a potential for medical intervention to be administered, either by their caregivers or via an implanted device automatically delivering electrical stimulation or medication, and finally save lives from fatal seizures. This article presents recent developments of SUDEP studies focusing on the pathophysiologic basis of SUDEP and computational implications of machine learning techniques that can be adapted and extended for SUDEP prediction. This article also discusses some novel ideas for SUDEP prediction and rescue including principal component analysis and closed-loop intervention.
Emerging insights into the relationship between pre-microRNA146a rs2910164 gene polymorphism and TNF-α in ischemic stroke
Authors: Elasmer Shimaa Mohammed , Zaki Osman , Elgendy Hanan , Kamal Manal , M. Abdel Halim Radwa 
Published: May 2022

Abstract

Objectives
This study investigated the association between the pre-miRNA146a C>G rs2910164 polymorphism and serum TNF-α in Egyptian patients with IS.

Methods
A case-control study was conducted on 75 Egyptian cases with IS and 75 sex-matched control subjects aged 57–65 years. Genomic DNA analysis of pre-miRNA146a and TNF-α measurement was performed with real-time PCR and ELISA, respectively.

Results
There was a statistically significant difference between cases of ischemic stroke (IS) and control subjects in pre-miRNA146a rs2910164 GG genotype (p=0.017) and G allele (p=0.005). The pre-miRNA146a rs2910164 is significantly associated with large artery atherosclerosis [LAA] in GG genotypes (p=0.019) and G alleles (p=0.004) compared to control subjects. There was a highly statistically significant increase in TNF-α levels (p<0.001) in IS compared to the control group. There was also a statistically significant increase in TNF-α levels (p=0.001) in GG genotypes in IS.

Conclusions
Our results showed that there was a statistically significant association between pre-miRNA146a rs2910164 GG genotype and susceptibility to IS and LAA. In addition, there was a statistically significant association between pre-miRNA146a rs2910164 GG genotype and TNF-α in IS subjects.
Cemented Paste Backfill Hydraulic Conductivity Evolution from 30 Minutes to 1 Week
Authors: Shahsavari Mohammad , Jafari Mohammadamin , Grabinsky Murray 
Published: May 2022

AbstractThe first one to four days constitutes a critical period in filling mining voids with cemented paste backfill (CPB, a mixture of mine tailings, binder, and water) and determining the saturated hydraulic conductivity (ksat) during this period is important to rational engineering design. However, most published studies started testing 24 h after specimen preparation, and those that started earlier did so by preconsolidating the specimens, which results in void ratios lower than those occurring in the field. This study uses a new test method that retains the backfill’s representative bulk properties and starts testing about one-half hour after specimen preparation. During backfilling, CPB undergoes three distinct ksat stages: a relatively constant high-value ksat stage associated with the portland cement’s (PC’s) dissolution phase; a rapidly declining ksat stage associated with PC’s acceleration phase; and then a slowly declining ksat stage associated with PC’s steady-stage and subsequent deceleration phase. The last two stages can be represented by modified Kozeny-Carman equations, in which the hydration effects are constant but different in each stage, and the ksat changes can be related to void ratio changes in each stage. In contrast, the distinct stages are not adequately represented by traditional PC “maturity” models, and, more importantly, the ksat values determined here are at least an order of magnitude higher than previously published results on similar materials.
A Shear Device with Controlled Boundary Conditions for Very Large Nonplanar Rock Discontinuities
Authors: Jeffery Michael , Crumpton Mason , Fityus Stephen G. , Huang Jinsong , Giacomini Anna , Buzzi Olivier 
Published: May 2022

Abstract
The shear strength of rock discontinuities is an important design parameter that is noted to be scale dependent. Historically, discontinuity shear strength and scale dependency studies have used small to medium size laboratory shear devices that accommodate specimens with a relatively small area (0.01 to 1 m2) compared to real discontinuities. In the literature, there is a limited amount of shear strength studies available on discontinuity surfaces with areas of several square meters. This is inherently linked to the challenging nature of performing large shear tests. As shear strength scale dependency is still a timely topic, there is still a need for conducting large scale direct shear tests to support research. To facilitate investigations into the shear response of large discontinuities, a very large shear device was designed and built at the University of Newcastle, Australia. The device is designed to accommodate 2 m by 2 m specimens and restrict rotation and translations of the top surface during shearing. This article presents the design and characteristics of the shear device, the process undertaken to create 2 m by 2 m mortar discontinuity replicas and the experimental results of the first series of direct shear tests conducted. The experimental results confirm the systems design for restricting undesired translations and rotations of the tested specimen surfaces and test repeatability.
Effect of Different Doses of Vitamin C Supplementation on Health and Performance of Badminton Players Based on Machine Learning
Authors: Deng Yudong , Liu Peihua 
Published: May 2022

Abstract
The Olympic Games are one of the most watched events in the world. The International Badminton Federation (IBF) began preparations for the Olympics in 1970, but the IBF World Championships were not until June 5, 1985. The 1992 Barcelona Olympics finally established badminton as an official sport. Athletes win their own honors during the competition. Under the competition field, athletes also attach great importance to their health. Many elements are beneficial to the body and also to athletes. Vitamins are one of the most important elements for athletes as the basis for achieving high scores. This article aims to study the effect of different doses of vitamin C (Vit.C) supplementation on health aspects based on machine learning for improving the performance of badminton players. In order to explore the different effects of different doses of Vit.C on the performance of athletes, 12 badminton players are taken as the object to control the intake of Vit.C to detect the relevant indicators of athletes’ physical fitness and to research and analyze the experimental results. The results of the study prove that different doses of Vit.C supplementation can affect the performance of badminton players. Vit.C helps the immune system resist viral and bacterial infections by enhancing the body’s immune function and bacterial activity. Different Vit.C supplements have different effects on athletes’ performance. There is an important connection: too much or too little will lead to a higher than normal 15 % or lower than normal 5 %; the overall change is about 5–25 %. Based on the detection method of machine learning, this paper studies the healthcare detection method of Vit.C on the performance improvement of badminton players and finally found that the method of detecting Vit.C in badminton players based on machine learning is very effective and can significantly improve the performance of badminton players.
TINGKAT DAYA TAHAN AEROBIK PESERTA SELEKSI PELATIHAN PEMANDU WISATA PARALAYANG DI KABUPATEN BATANG TAHUN 2020
Authors: Sukmana Tatas Aldian , Sugiarto Sugiarto 
Published: May 2022

Tujuan dari penelitian ini adalah untuk mengetahui tingkat daya tahan aerobik lari 12 menit peserta seleksi pelatihan pemandu wisata paralayang di Kabupaten Batang pada tahun 2020. Jenis penelititan ini adalah deskriptif kuantitatif menggunakan metode survei sekunder dengan menggunakan teknik tes dan pengukuran. Populasi dalam penelitian ini adalah peserta seleksi pelatihan pemandu wisata paralayang Kabupaten Batang, sedangkan sampel dalam penelitian ini adalah peserta seleksi pelatihan pemandu wisata paralayang Kabupaten Batang putra yang megikuti seleksi pelatihan pemandu wisata paralayang Kabupaten Batang pada tahun 2020. Teknik pengambilan sampel dalam penelitian ini menggunakan purpossive sampling. Teknik purpossive sampling digunakan karena peneliti menentukan sampel dengan syarat tertentu. Dalam penelitian ini peneliti memilih sampel dengan kriteria peserta seleksi pelatihan pemandu wisata paralayang Kabupaten Batang yang memiliki jenis kelamin laki-laki. Hasil dari penelitian ini menunjukan bahwa kemampuan daya tahan aerobik peserta seleksi pelatihan paralayang Kabupaten Batang sebanyak 22 peserta (88%) dalam kategori baik sekali, dan 3 peserta (12%) dalam kategori baik. Kesimpulan dari hasil penelitian ini adalah sebagian besar sampel dalam penelitian tingkat daya tahan aerobik peserta seleksi pelatihan pemandu wisata paralayang Kabupaten Batang Putra pada tahun 2020 memiliki tingkat daya tahan aerobik termasuk dalam kategori baik sekali dan sebagian kecil memiliki tingkat daya tahan aerobik baik.
PENGELOLAAN SARANA DAN PRASARANA WISATA OLAHRAGA ARUNG JERAM DI LOLONG ADVENTURE KABUPATEN PEKALONGAN
Authors: Maslivah Vita Soniya , Sugiarto Sugiarto 
Published: May 2022

Tujuan dari penelitian ini adalah untuk mengetahui pengelolaan sarana dan prasarana wisata olahraga arung jeram di Lolong Adventure Kabupaten Pekalongan tahun 2021. Penelitian ini menggunakan adalah pendekatan kualitatif. Objek dalam penelitian ini adalah Sarana dan Prasarana Wisata Olahraga Arung Jeram di Lolong Adventure, Kabupaten Pekalongan, sedangkan subjek dalam penelitian ini adalah pengelola dan pemandu di Lolong Adventure. Instrumen dalam penelitian ini menggunakan pedoman observasi, wawancara dan dokumentasi. Teknik analis data melalui reduksi data dilanjutkan dengan kategorisasi data dan sintesisasi data. Hasil penelitian ini menunjukan perencanaan pengadaannsarana dan prasarana wisata olahraga arung jeram dilakukannsetiap awal tahun, setelah itu diadakan pengadaan yang disesuaikan dengan pendanaan yang didapat dari hasil pengunjung yang datang ke Lolong Adventure. Pemeliharaan dilakukan melalui kerjasama dengan semua anggota karyawannya. Perbaikan kecil dilakukan oleh teknisi yang ada di Lolong Adventure. Perbaikan dengan skala besar dilakukan oleh tekniksi yang bisa atau dari luar. Terdapat tempat penyimpanan yang secara rapih. Kesimpulan dari hasil penelitian ini adalah pengelolaan sarana dan prasarana Wisata Olahraga Arung Jeram dapat dikatakan sudah berjalan dengan baik karena pengelolaan dilakukan secara terperinci memperhatikan pengadaan, pemeliharaan, dan peningkatan sarana dan prasarana wisata olahraga arung jeram di Lolong Adventure.
Steroid treatment in the management of destructive thyrotoxicosis induced by PD1 blockade
Authors: Brancatella Alessandro , Pierotti Laura , Viola Nicola , Lupi Isabella , Montanelli Lucia , Cremolini Chiara , Piaggi Paolo , Chella Antonio , Antonuzzo Andrea , Sgrò Daniele , Antonangeli Lucia , Sardella Chiara , Brogioni Sandra , Marcocci Claudio , Santini Ferruccio , Latrofa Francesco 
Published: May 2022

Objective
Destructive thyroiditis is the most common endocrine immune-related adverse event (iRAEs) in patients treated with anti-PD1/PD-L1 agents. Given its self-limited course, current guidelines recommend no treatment for this iRAE. Nevertheless, in patients with enlarged thyroid volume and a poor performance status, thyrotoxicosis may be particularly severe and harmful. The aim of the study is to evaluate if steroid treatment might be useful in improving thyrotoxicosis in subjects with a poor performance status.

Methods
We conducted a retrospective study, comparing the course of thyrotoxicosis of four patients treated with oral prednisone at the dosage of 25 mg/day (tapered to discontinuation in 3 weeks) and an enlarged thyroid volume to that of eight patients with similar thyroid volume who were left untreated.

Results
The levels of thyroid hormones were lower in subjects treated compared to those untreated at time of 7, 14, 21, 28, 35, 42, 60 and 90 days (P  < 0.05 at each time). The time to remission of thyrotoxicosis was 24 days in patients treated with steroids and 120 days in untreated patients (P  < 0.001). At 6 months, the rate of evolution to hypothyroidism was similar in the two groups (4/4 in the steroid group vs 7/8 in the untreated group, P  = 0.74) and no difference was found in tumor progression (P  = 0.89).

Conclusions
Our preliminary data suggest that in patients with a poor performance status experiencing a severe destructive thyrotoxicosis induced by PD-1 blockade, a short period of administration of oral prednisone is effective in obtaining a quick reduction of the levels of thyroid hormones.
The Effects of the COVID-19 Pandemic on Cardiac Surgery Volumes and Outcomes in New Zealand
Authors: Mekhail Andrew , Mekhail Ann-Marie , Galvin Sean 
Published: May 2022

Aim:
New Zealand adopted an “elimination strategy” in response to the 2020 COVID pandemic with strict early border controls and early national lockdowns. The international experience of cardiac surgery provision during the COVID pandemic was of reduced case numbers, difficulties with the provision of elective surgery and in some cases increased morbidity associated with waiting for surgery and from developemnt of the infection in post operative patients. We aim to review the effects the COVID-19 pandemic has had on adult cardiac surgery volumes and outcomes in the Wellington region.
Method:
Utilising local data submitted to the New Zealand National cardiac surgical database, we analysed all cardiac operations completed at a tertiary cardiothoracic centre between January 1st 2019 till December 31st 2020. The COVID-19 lockdown period (March-April 2020) was compared with its’ 2019 counterpart as well as the sequential months to analyse for any ‘rebound’ effect. Number of surgeries, proportion of elective cases, and surgery type were assessed.
Results:
The lockdown period of March-April/2020 showed a higher number of cardiac surgery cases per month compared to a the same period in 2019 (48.5 vs 39.0 cases/month, P=0.74). A surge in acute cases was noted in September–December 2020 with 57 acute operations completed, compared to 23 for the corresponding time period in 2019.
Conclusion:
The New Zealand response to the COVID pandemic resulted in low relative rates of community transmission and only a small number of patients admitted to hospital. We did not see a reduction in routine cardiac operations or changes in clincial outcome over this period. Despite the lockdown period, due to low numbers of community and COVID cases in our ICU and hospital we were able to maintain a full operating capacity throughout. We did observe an increase in acute cases following the lockdown likely due to the reduced access to routine cardiology clinics and deferrable diagnostic services.
Reserve your judgment on “Draconian” Chinese video gaming restrictions on children •
Authors: Xiao Leon Y. 
Published: May 2022

Abstract
China imposed strict restrictions on young people's participation in videogaming from September 2021. Colder Carras et al.'s commentary (2021) referred to this policy as ‘draconian,’ i.e., ‘excessively harsh and severe.’ However, any opinion on whether this policy is ‘draconian’ is a value judgment, and any judgment on its ‘effectiveness’ ought to be reserved until proven or disproven by empirical evidence. Indeed, the Chinese policy is neither potentially ineffective nor draconian, and is already providing at least one identifiable benefit: enhancing consumer protection by effectively reducing underage players' monetary spending on videogames, including on randomised, gambling-like mechanics known as ‘loot boxes.’
A rare case report of total uterine rupture from cervix to fundus in an unmarried teenage pregnancy
Authors: Elango Shanthi K. , Taj Rizwana , M. Monisha 
Published: May 2022

Uterine rupture is an uncommon and a life threatening obstetric complication. It is mainly a result of delivery by untrained personnel. This is a catastrophic situation where there is a high mortality rate for both the mother and the baby and a nightmare for the obstetrician also. There are many cases of uterine trauma reported in which there may be scar dehiscence, scar rupture, uterine rupture,perforation, cervical injuries, colporrhexis etc.This case report is regarding an unusual and rare presentation of a 19 year old unmarried girl who landed in our institution-a case of total and complete uterine rupture extending from cervix to fundus, a peculiar presentation, a hazardous result of Youtube delivery by her boyfriend highlighted. A scenario where the maternal anatomy totally distorted due to the trauma. This patient managed by immediate resuscitation and uterus reconstructive surgery successfully. In spite of the advice not to conceive for the next few years, patient turned back to us in the late trimester within the next year itself, again a big challenge. Both the mother and baby managed successfully .With this case report we emphasize the need for immediate intervention in case of suspected uterine rupture and the possibility of successful subsequent pregnancy highlighted.
De novo SOX6 variant: Tolchin-Le Caignec syndrome
Authors: Sinha Rahul , Singh Sonali , Kamila Gautam 
Published: May 2022

Tolchin-Le Caignec syndrome (TOLCAS) is a developmental disorder characterized by intellectual impairment and behavioural issues such as autism, hyperactivity, aggressive episodes and mood swings and lack of sleep. The other manifestations include osteochondroma, craniosynostosis, dysmorphic facies, arachnodactyly, prominent occiput and bitemporal narrowing. We reported this rare syndrome in a 5 and half year old female child who presented with global developmental delay (language and cognitive predominant), autistic features, hyperactivity, aggressive behaviour and dysmorphism (high forehead, bitemporal narrowing, micrognathia, low set ears, hypertelorism, wide nasal bridge, scaphocephaly, clinodactyly). The whole exome sequencing detected de novo heterozygous missense pathogenic variant c.1378A>C, p. (Asn460His) in exon 11 of SOX6 gene with no similar variant found in either of the parents confirmed the diagnosis of TOLCAS. This rare case report highlighted the phenotypic variation due to SOX6 gene mutation which the clinician should be aware of while dealing with dysmorphic child with cognitive and language delay with autistic features.
Intraosseous polymorphous adenocarcinoma of mandible
Authors: Gopal Ashish , Sahoo Anjan , Sharma Raman , Singh Karandeep , Mandal Shramana 
Published: May 2022

<p class="abstract">Polymorphous Adenocarcinoma (PAC) is a type of salivary gland tumor commonly arising in the minor salivary glands with palate being the most frequent site of origin. PACs harbor recurrent PRKD1 E710D hotspot mutations in &gt;70% of cases. It has propensity of malignant transformation along with locoregional or distant metastasis. However, the latter is very rare entity. Often challenging for both the pathologist and surgeon is the histologic difference between other conditions like pleomorphic adenoma, adenoid cystic carcinomas and adenocarcinoma not otherwise specified. Interestingly, very rare sites of occurrence may herald the rarity, therefore the intraosseous origin in the maxilla and the mandible are seldom encountered. One such very rare case of PAC of the mandible with extensive destruction of hemimandible and the areas in the vicinity of the tumour with nodal and distant bony metastasis described here.</p>
​​Research Prioritization in Indian Livestock Sector: A Policy Appraisal
Authors: Bardhan D. , Singh S.R.K. , Raut A.A. 
Published: May 2022

Background: Livestock makes multi-faceted contribution to socio-economic development of rural people. However, challenges exist in exploiting the opportunities offered by this sector. Focused research efforts will be a key factor in addressing these challenges. There is a need for a critical and objective evaluation of livestock research priorities at the regional, species and commodity-specific levels so as to ensure optimum use of scarce resources. This study was aimed to identify regional, species and commodity wise priorities for allocation of livestock research resources. Methods: The study used multi-criteria scoring model incorporating the multiple objectives for making choices. The objectives included were growth, equity, sustainability and participation in trade. Such scoring models are used to rank a long list of commodities, research alternatives and target domains. Result: The study identified regional, species and commodity priorities for allocation of livestock research resources. Significant tradeoffs in the priority rankings of states were revealed when equity and sustainability indicators were considered. Species-wise prioritization including all the criteria revealed that cattle and buffalo stake the highest claims on research resources. The study also revealed inter-regional variations in allocation of research resources based upon species.