bluuebunny/crossref_metadata_2025_split huggingface dataset:
The therapeutic effect of glucocorticoids on type II respiratory failure, heart failure, and massive pericardial effusion caused by hypothyroidism: A case report
Authors: Wang Jingyue , Li Xiangjun , Shen Botao , Wang Shipeng , He Jiahuan , Wang Yushi 
Published: October 2022

Background: Hypothyroidism is a disease commonly observed in outpatient clinics but can occasionally cause severe cardiovascular and respiratory diseases requiring hospitalization.Case report: The patient reported herein suffered from heart failure, massive pericardial effusion, type II respiratory failure, and hypothyroidism. There was no related basic diseases of respiratory and cardiovascular system in the past. She failed to be weaned from invasive ventilation multiple times after routine treatment and was finally successfully weaned on day five of receiving the combination therapy of a high-dose methylprednisolone intravenous drip and levothyroxine oral administration.Conclusion: This case report indicates that hypothyroidism may be a cause of type II respiratory failure, heart failure, and massive pericardial effusion without cardiac tamponade and that a combination of levothyroxine and corticosteroids could effectively treat the disease. Clinical workers should consider the role of thyroid function in diagnosis, and the admission team should include this aspect in the monitoring scope. Moreover, the role of hormones in the treatment of patients with severe hypothyroidism should not be ignored, and timely treatment should be provided.
The application of gargle containing honeysuckle and semen oroxyli to reduce the pain and complications after uvulopalatopharyngoplasty
Authors: Ren Lihua , Li Jun , Miao Zhongyi , Yan Ru , Li Qunzhen , Zhang Rong , Rong Ting , Dong Xuena 
Published: October 2022

Purpose: The main purpose of this pilot study was to detect the positive effects of our self-made gargle containing honeysuckle and semen oroxyli on post-operative pain and complications after Uvulopalatopharyngoplasty (UPPP).Methods: Patients with obstructive sleep apnea (OSA) who had underwent elective UPPP during the period of April 2019 to January 2022 were randomly divided into treatment group and control group. The patients in the treatment group were instructed to gargle the solution containing honeysuckle and semen oroxyli (25 ml) four times a day for 2 weeks. The patients in the control group were instructed to gargle normal saline (25 ml) at the same schedule. The post-operative resting throat pain, swallowing throat pain and patient comfort level were evaluated at 12 h, 1 week and 2 weeks after UPPP. The post-operative complications were collected and analyzed.Results: During the study period, 218 patients completed all the post-operative assessments. For resting throat pain, the treatment group had much lower VAS scores at 1 week and 2 weeks after UPPP. For swallowing throat pain, treatment group had much lower VAS scores than control group at 2 weeks after surgery. And patients in the treatment group felt more comfortable comparing to those in control group at 1 week and 2 weeks after UPPP. Although the treatment group had less numbers of patients with post-operative wound infection or bleeding, the difference between the 2 groups was not statistically significant.Conclusion: The gargle containing honeysuckle and semen oroxyli could relieve both resting and swallowing throat pain and increase patient comfort after UPPP.
Pharmacological OGG1 inhibition decreases murine allergic airway inflammation
Authors: Tanner Lloyd , Bergwik Jesper , Bhongir Ravi K. V. , Pan Lang , Dong Caijuan , Wallner Olov , Kalderén Christina , Helleday Thomas , Boldogh Istvan , Adner Mikael , Egesten Arne 
Published: October 2022

Background and aim: Allergic asthma is a complex inflammatory disease involving type 2 innate lymphoid cells, type 2 T helper cells, macrophages, and eosinophils. The disease is characterized by wheezing, dyspnea, coughing, chest tightness and variable airflow limitation for which there is no cure and is symptomatically treated with inhaled corticosteroids and β2-agonists. Molecular mechanisms underlying its complex pathogenesis are not fully understood. However, 8-oxoguanine DNA glycosylase-1 (OGG1), a DNA repair protein may play a central role, as OGG1 deficiency decreases both innate and allergic inflammation.Methods: Using a murine ovalbumin (OVA) model of allergic airway inflammation we assessed the utility of an inhibitor of OGG1 (TH5487) in this disease context. Cytokines and chemokines, promoting immune cell recruitment were measured using a 23-multiplex assay and Western blotting. Additionally, immune cell recruitment to bronchi was measured using flow cytometry. Histological analyses and immunofluorescent staining were used to confirm immune cell influx and goblet cell hyperplasia of the airways. A PCR array was used to assess asthma-related genes in murine lung tissue following TH5487 treatment. Finally, airway hyperresponsiveness was determined using in vivo lung function measurement.Results: In this study, administration of TH5487 to mice with OVA-induced allergic airway inflammation significantly decreased goblet cell hyperplasia and mucus production. TH5487 treatment also decreased levels of activated NF-κB and expression of proinflammatory cytokines and chemokines resulting in significantly lower recruitment of eosinophils and other immune cells to the lungs. Gene expression profiling of asthma and allergy-related proteins after TH5487 treatment revealed differences in several important regulators, including down regulation of Tnfrsf4, Arg1, Ccl12 and Ccl11, and upregulation of the negative regulator of type 2 inflammation, Bcl6. Furthermore, the gene Clca1 was upregulated following TH5487 treatment, which should be explored further due to its ambiguous role in allergic asthma. In addition, the OVA-induced airway hyperresponsiveness was significantly reduced by TH5487 treatment.Conclusion: Taken together, the data presented in this study suggest OGG1 as a clinically relevant pharmacological target for the treatment of allergic inflammation.
Proactive personality and critical thinking in Chinese medical students: The moderating effects of psychological safety and academic self-efficacy
Authors: Wang Yan-ping , Zhao Chen-xi , Zhang Shu-e , Li Qing-lin , Tian Jing , Yang Mao-ling , Guo Hai-chen , Yuan Jia , Zhou Sheng-yan , Wang Min , Cao De-pin 
Published: October 2022

ObjectivesThis study aimed to identify the relationship among proactive personality, psychological safety, academic self-efficacy and critical thinking, and to further explore whether psychological safety and academic self-efficacy could be a moderator in the association between proactive personality and critical thinking among Chinese medical students.Materials and methodsThe cross-sectional study was carried out from October to December 2020 in China. Totally, 5,920 valid responses were collected at four Chinese medical universities. Critical thinking, proactive personality, psychological safety, academic self-efficacy and demographic factors were assessed through questionnaires. Hierarchical multiple regression was used to identify interrelationship clusters among variables. Simple slope analyses were performed to explore the moderating effects of psychological safety and academic self-efficacy.ResultsThe mean score of critical thinking among medical students was 3.85 ± 0.61. Proactive personality, psychological safety, and academic self-efficacy were shown to be important factors for critical thinking. Psychological safety and academic self-efficacy moderated the association between proactive personality and critical thinking. A simple slope analysis showed that high psychological safety and academic self-efficacy weakened the impact of proactive personality on critical thinking.ConclusionMost medical students surveyed in China might have relatively high levels of critical thinking. Psychological safety and academic self-efficacy moderated the association between proactive personality and critical thinking. More interventions related to psychological safety and academic self-efficacy will be helpful to improve critical thinking among Chinese medical students.
The risk of falls among the aging population: A systematic review and meta-analysis
Authors: Xu Qingmei , Ou Xuemei , Li Jinfeng 
Published: October 2022

AimThis study aims to clarify the risk factors for falls to prevent severe consequences in older adults.MethodsWe searched the PubMed, Web of Science, Embase, and Google Scholar databases using the terms “risk factors” OR “predicting factors” OR “predictor” AND “fall” OR “drop” to identify all relevant studies and compare their results. The study participants were divided into two groups, the “fall group” and the “control group”, and differences in demographic characteristics, lifestyles, and comorbidities were compared.ResultsWe included 34 articles in the analysis and analyzed 22 factors. Older age, lower education level, polypharmacy, malnutrition, living alone, living in an urban area, smoking, and alcohol consumption increased the risk of falls in the aging population. Additionally, comorbidities such as cardiac disease, hypertension, diabetes, stroke, frailty, previous history of falls, depression, Parkinson's disease, and pain increased the risk of falls.ConclusionDemographic characteristics, comorbidities, and lifestyle factors can influence the risk of falls and should be taken into consideration.
Psychological research of the children with chronic kidney disease and their guardians during the COVID-19 pandemic
Authors: Xiong Hua-Ying , Zhang Gaofu , Wang Li , Li Zhijuan , Shen Qian , Li Yuhong , Zhu Hongtao , Du Yue , Sun Liangzhong , Zhao Bo , Zhao Lijun , Fu Haidong , Li Xiaoyan , Gao Xiaojie , Hao Sheng , Ding Juanjuan , Chen Zongwen , Xu Zhiquan , Liu Xiaorong , Tao Yuhong , Zhang Aihua , Li Qiu , Wang Mo 
Published: October 2022

BackgroundThere is great mental stress due to the coronavirus disease 2019 (COVID-19) pandemic. However, there are no detailed psychological studies of the children with chronic kidney disease (CKD) and their guardians during the COVID-19 pandemic.ObjectiveThis study explores the psychological pressure on children with CKD and their guardians.MethodsAn online survey was conducted at 20 of the largest pediatric nephropathy departments in China, including the Rutter Parent Questionnaire, Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS). Overall, 885 children (589 children with CKD associated with 296 children of the control group) completed the survey together with their guardians.ResultsThere was no statistical difference between CKD children and control children regarding their Rutter behavior scores and abnormal behaviors. Nevertheless, the abnormal behavior of children might aggravate the anxiety and depression of guardians in both CKD and control groups (p &lt; 0.05). We confirmed that the anxiety and depression of guardians in the CKD group were both significantly higher than those in the control group (p &lt; 0.05). The guardians in the CKD group with lower annual income were more likely to experience anxiety (p &lt; 0.05). Furthermore, the guardians whose children were older than 11 years old might be more anxious than those who were 6–11 years old. Besides, the guardians in the CKD group who watched the news for 30–60 min daily were less likely to have depression than those who watched &lt; 10 min (p &lt; 0.05). The subgroup results showed that the gender, the time of watching the news, the annual income of guardians, and children's age might be the most critical factors influencing guardians' psychological burden.ConclusionThe guardians in the CKD group have more severe anxiety and depression during the pandemic. The children's abnormal behavior, adolescents' pressure, low household income, and the panic about the pandemic may be the main reasons for the anxiety and depression of guardians.
Organizational commitment of health professionals and associated factors in primary healthcare facilities of Addis Ababa, Ethiopia: A multi-center cross-sectional study
Authors: Arage Sulyeman Mohammed , Daba Derese Bekele , Dessalegn Abere Yekoye 
Published: October 2022

BackgroundOrganizational commitment has a positive impact on an organization's ability to provide professional services. Committed human power pushes an organization to achieve its goals, but non-commitment can lead to increased medical errors, prolonged inpatient admissions, and repeated hospitalizations leading to low quality of healthcare provision. However, to the best knowledge of researchers, there are no studies examining organizational commitment in the healthcare setting of Addis Ababa, Ethiopia.ObjectiveThe aim of this study was to assess the level of organizational commitment and associated factors among health professionals working in the primary health facility of Addis Ababa, Ethiopia.MethodsA facility-based cross-sectional study was conducted among 459 healthcare professionals selected by simple random sampling from 12 health centers. Data were collected by three data collectors and one supervisor using a pretested questionnaire. Data were checked for completeness, cleaned, and entered into Epi-Data version 3.1.and exported into SPSS version 25 for analysis. In binary logistic regression statistical analysis, variables with p &lt; 0.2 were entered in multivariate binary logistic regression analyses; then, the regression result was presented using COR, AOR with 95% CI, and a p-value &lt; 0.05 as a level of significance.ResultThe respondent's percent mean score of organizational commitment was 48.4%. Age group above 30 years (AOR = 1.52, 95% CI, 1.01, 2.30), those who were satisfied with their job (AOR 2.02, 95% CI 1.30, 3.13), and those who perceive good transformational leadership behavior (AOR: 1.85, 95% C.I, 1.18, 2.90) were significant factors of organizational commitment among health professionals.Conclusion and recommendationOrganizational commitment was lower in magnitude in the study setting. Age, job satisfaction, and transformational leadership behavior were significant predictors of organizational commitment.
Radiosynthesis and Preclinical Evaluation of an 18F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A)
Authors: Wenzel Barbara , Fritzsche Stefan R. , Toussaint Magali , Briel Detlef , Kopka Klaus , Brust Peter , Scheunemann Matthias , Deuther-Conrad Winnie 
Published: October 2022

The cyclic nucleotide phosphodiesterase 2A is an intracellular enzyme which hydrolyzes the secondary messengers cAMP and cGMP and therefore plays an important role in signaling cascades. A high expression in distinct brain areas as well as in cancer cells makes PDE2A an interesting therapeutic and diagnostic target for neurodegenerative and neuropsychiatric diseases as well as for cancer. Aiming at specific imaging of this enzyme in the brain with positron emission tomography (PET), a new triazolopyridopyrazine-based derivative (11) was identified as a potent PDE2A inhibitor (IC50, PDE2A = 1.99 nM; IC50, PDE10A ~2000 nM) and has been radiofluorinated for biological evaluation. In vitro autoradiographic studies revealed that [18F]11 binds with high affinity and excellent specificity towards PDE2A in the rat brain. For the PDE2A-rich region nucleus caudate and putamen an apparent KD value of 0.24 nM and an apparent Bmax value of 16 pmol/mg protein were estimated. In vivo PET-MR studies in rats showed a moderate brain uptake of [18F]11 with a highest standardized uptake value (SUV) of 0.97. However, no considerable enrichment in PDE2A-specific regions in comparison to a reference region was detectable (SUVcaudate putamen = 0.51 vs. SUVcerebellum = 0.40 at 15 min p.i.). Furthermore, metabolism studies revealed a considerable uptake of radiometabolites of [18F]11 in the brain (66% parent fraction at 30 min p.i.). Altogether, despite the low specificity and the blood–brain barrier crossing of radiometabolites observed in vivo, [18F]11 is a valuable imaging probe for the in vitro investigation of PDE2A in the brain and has potential as a lead compound for further development of a PDE2A-specific PET ligand for neuroimaging.
Analysis of dental status in children with type I diabetes mellitus: a literature review
Authors: Chuykin S. V. , Akatyeva G. G. , Malievsky O. A. , Makusheva N. V. , Bayburina E. K. , Kuchuk K. N. , Chuykin G. L. , Petrova E. A. 
Published: October 2022

Relevance. Diabetes mellitus is one of the most complex metabolic chronic diseases. Severe forms of type I diabetes mellitus are more common in children and adolescents, and its prevalence is increasing in many countries. Type I diabetes mellitus in children and adolescents remains an essential health issue in many countries despite the achieved scientific and practical results and progress in diabetology. Therefore, its early detection in children is still relevant and is associated with the early diagnosis of endocrinolog ical pathologies.Materials and methods. The study searched the publications in PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), Medline (www.elibrary.ru, www.ncbi.nlm.nih.gov/pubmed) by the specific keywords.Results. In children with diabetes mellitus, vascular changes in periodontal tissues appear earlier than in other organs. On oral examination of children with diabetes mellitus, 50% of cases reveal periodontal lesions, and the lesions are often in the areas of the lower molars. If not treated, the following perio-dontitis signs are present in diabetic children: bleeding of the gingival papillae and the bright red colour of the gingival margin. There may be bulging of granulations from pathological gingival pockets. In most patients with type I diabetes mellitus, cytology of the periodontal pockets and gingival sulci demonstrated inflammatory cytologic responses, changes in the stratified squamous epithelium, and mixed bacterial microflora with leukocytes and erythrocytes.Conclusion. The study of type I diabetes mellitus impact on pathological changes in the oral cavity of children and the development of therapeutic and preventive measures is a relevant issue in pediatric dentistry, which justifies the need to continue research in this area.
Results of orthodontic treatment of permanent upper incisors intrusive luxation: a clinical case
Authors: Simakova A. A. , Gorbatova L. N. , Gorbatova M. A. , Goldberg M. A. , Podrezova A. V. , Popov V. A. 
Published: October 2022

Relevance. Dental trauma prevalence is high among children. Treatment of intrusive luxation, where the choice of treatment technique depends on the root formation stage, is of particular interest.Clinical case description. The article presents the treatment results of an 8-year-old patient with mixed dentition. The patient was diagnosed with an intrusive luxation of teeth 1.1, 2.1, soft tissue contusion, and fracture of the maxillary alveolar process.Thirteen days after the injury, we started the orthodontic treatment with a bracket system (ROTH 018 Micro-Sprint) placed on the upper teeth, controlled by cone-beam computed tomography (CBCT). Arches and elastics were consecutively changed during the treatment. In nine and a half months, teeth 1.1 and 2.1 were extruded. Functional and aesthetic parameters were restored. We assessed stability of the obtained result 18 months after the start of orthodontic treatment.Conclusion. The intrusive luxation treatment planning calls for a thorough history and diagnosis data comparison. The choice of non-surgical treatment without tooth extraction requires informing the patient about possible complications, treatment difficulties and long-term follow-up observation. The successful treatment outcome needs comprehensive patient management by a multidisciplinary team of a maxillofacial surgeon, pediatric dentist, orthodontist and other related specialists, if necessary.
КОРУПЦІЯ В ПУБЛІЧНОМУ УПРАВЛІННІ ЯК ПЕРЕПОНА ПЕРЕХОДУ СУСПІЛЬСТВА ДО ІНДУСТРІЇ 4.0
Authors: Shpak Yuryi , Dragan Ivan 
Published: October 2022

Перехід до Індустрії 4.0 передбачає використання інноваційного потенціалу, який також визначається інституційним середовищем, зокрема рівнем корупції та її сприйняттям. Посткомуністичні країни Центральної та Східної Європи характеризуються вищим рівнем корупції та більшою часткою тіньової економіки, що може фундаментально знизити їхній інноваційний потенціал і таким чином стати гальмом переходу до Індустрії 4.0. Таким чином, мета цієї статті полягає в тому, щоб оцінити вплив корупції в державному управлінні на розмір і структуру тіньової економіки, а також визначити, чи може наявність корупції вплинути на перехід країни та суспільства до Індустрії 4.0. У статті встановлено, що корупція в державному управлінні має набагато більш руйнівний і довгостроковий вплив на накопичення капіталу, ніж на чисельність робочої сили. У цьому сенсі корупція може стати суттєвою перешкодою для переходу, підкреслюючи, що завдання державної політики полягає не лише в підтримці цифровізації, роботизації та подальшого розвитку технологій, але особливо в забезпеченні прозорого некорупційного середовища державного управління.
Vulneración a la seguridad jurídica y legalidad en la aplicación del convenio de pago
Authors: Silva-Vargas Andersson Junior , Ormaza-Ávila Diego Adrián 
Published: October 2022

El presente trabajo se enfoca en analizar y determinar las vulneraciones al derecho de seguridad jurídica y principio de legalidad en la contratación pública derivadas de las actuaciones administrativas implementadas en el procedimiento de suscripción de convenios de pagos “por parte del Instituto Ecuatoriano de Seguridad Social”. De alcance metodológico descriptivo. Entre los resultados obtenidos se determina que la falta de normas y “disposiciones jurídicas previas, claras y públicas” sobre el convenio de pago influyen sustancialmente en errores y falencias administrativas, en la inobservancia y elución de los procedimientos previstos en la LOSNCP, provocando grandes pérdidas económicas el erario fiscal. Consecuentemente, es vital prescindir de las disposiciones que dan fundamento al ilegal acto administrativo que permite reconocer las obligaciones pendientes de pago mediante el convenio de pago.
Tingkat Pengetahuan Terhadap Ibu Hamil Resiko Tinggi Melalui Kompetensi Soft Skill dan Kinerja Petugas Kesehatan
Authors: Rukina Rukina , Pangastuti Dwi 
Published: October 2022

Pendahuluan: membangunan kesehatan merupakan cara untuk meningkatkan kesadaran, kemauan dan kemampuan untuk hidup sehat bagi setiap orang sehingga tingkat kesehatan masyarakat yang optimal dapat tercapai.
Tujuan: mengetahui pengaruh tingkat pengetahuan terhadap ibu hamil resiko tinggi melalui kompetensi soft skill dan kinerja petugas kesehatan.
Metode: Penelitian kuantitatif yang dilaksanakan. Populasi penelitian adalah seluruh ibu hamil. Tehnik sampling adalah simple random sampling dengan rumus slovin sehingga sampel penelitian ini adalah 126 orang. Teknik pengumpulan data melalui observasi, kuesioner, wawancara dan dokumentasi, sedangkan teknik analisis data menggunakan path analysis.
Hasil: menunjukkan bahwa kehamilan resiko tinggi dapat ditangani dengan semakin baiknya tingkat pengetahuan, kompetensi soft skill dan juga kinerja tenaga kesehatan. Tingkat pengetahuan merupakan variabel yang memiliki pengaruh dominan terhadap kehamilan resiko tinggi yang ditunjukkan dengan tingginya advokasi dan pemberdayaan yang dilakukan oleh tenaga kesehatan dalam mendukung kualitas kehamilan.
Kesimpulan: bahwa kehamilan resiko tinggi dapat ditangani dengan semakin baiknya tingkat pengetahuan, kompetensi soft skill dan juga kinerja tenaga kesehatan. Meskipun demikian kompetensi soft skill dan juga kinerja tenaga kesehatan memberikan kontribusi yang baik dalam meningkatkan kualitas kehamilan