bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined systemic inflammatory immunity index and prognostic nutritional index scores as a screening marker for sarcopenia in patients with locally advanced gastric cancer
Authors: Ding Ping'an , Lv Jingxia , Sun Chenyu , Chen Shuya , Yang Peigang , Tian Yuan , Zhou Qin , Guo Honghai , Liu Yang , Zhao Qun 
Published: August 2022

BackgroundSarcopenia is associated with poor clinical outcomes in patients with locally advanced gastric cancer (LAGC). Currently, the diagnostic criteria for sarcopenia are complex and laborious. Increased evidence suggests the inflammatory state of the body is closely associated with the development of sarcopenia. The systemic immune-inflammatory index (SII) and the prognostic nutritional index (PNI) are representative blood indicators of the status of the systemic inflammatory response, but the clinical significance of the combined testing of these two indicators remains unclear. We aimed to develop a simple and practical risk score (SII-PNI score) to screen patients with LAGC for sarcopenia on admission for early diagnosis.MethodsWe registered a prospective clinical study from January 2011 to May 2016 involving 134 patients with LAGC undergoing radical surgical resection. All patients followed the definition of sarcopenia in the Asian Working Group on Sarcopenia (AWGS) guidelines and were divided into sarcopenia and non-sarcopenia groups. SII-PNI score 0–2 was scored as 2 for high SII (≥432.9) and low PNI ( ≤ 49.5); score 1, either high SII or low PNI; score 0, no high SII or low PNI.ResultsAll patients underwent radical surgery, including 31 patients (23.13%) with sarcopenia according to AWGS criteria. The SII-PNI score was significantly lower in the non-sarcopenic patients than in the sarcopenic patients (p &lt; 0.001). Logistic multivariate analysis showed that the SII-PNI score predicted an independent prognostic factor for sarcopenia (p &lt; 0.001). Patients with high SII-PNI scores had significantly worse prognosis than those with low SII-PNI scores (p &lt; 0.001). The SII-PNI score was an independent prognostic factor for predicting overall survival and disease-free survival (p = 0.016, 0.023).ConclusionPeripheral blood parameters SII-PNI scores accurately identify sarcopenia in patients with LAGC and could be used as potential systemic markers.
Authorization of COVID-19 clinical trials: lessons from 2 years of experience of a national competent authority
Authors: Vignot Stéphane , Dhanani Alban , Sainte-Marie Isabelle , de Ligniville Lajavardi Laure , Even Gwennaelle , Echemann Muriel , Hulin Nina , Ménoret Claire , Maison Patrick , Ratignier-Carbonneil Christelle 
Published: August 2022

The COVID-19 pandemic was immediately marked by strong clinical research activity. The French national competent authority presents the data on request for authorization during the first 2 years of COVID-19 pandemic to inform discussions on future clinical research issues. Applications for authorization of interventional COVID-19 trials submitted between March 2020 and February 2022 were analysed. Trials on medicinal products were classified according to market authorization status, mechanism of action of the investigational product, target population and clinical context. In 2 years, 208 clinical trials were submitted. 75% were authorized, 3% refused, 22% withdrawn by the sponsor. Among medicinal products trials, 6% were adaptative, 28% included outpatients and 2% were focused on post COVID-19 symptoms. Vaccines were evaluated in 9% of trials, antivirals in 38% and immunomodulators in 35%; 63% of antiviral and 60% of immunomodulation trials included a drug with a marketing authorization in another indication. The dynamics of authorization prove the involvement of stakeholders but also illustrates the risk of dispersion of research efforts and the risk of decorrelation between trials and the epidemic evolution. The high rate of withdrawal of applications could be explained by changes in the sanitary context and by the dropping of some therapeutic approaches. Most of clinical trials evaluate drugs authorized in another indication and assessment procedures by authorities have to mitigate between the knowledge of safety profile of those drugs and the uncertainty in a new clinical context with rapidly evolving knowledge. COVID-19 experience should now support future evolution in clinical research practices.
Finasteride Alleviates High Fat Associated Protein-Overload Nephropathy by Inhibiting Trimethylamine N-Oxide Synthesis and Regulating Gut Microbiota
Authors: Wang Zuoyuan , You Li , Ren Yuan , Zhu Xiaoye , Mao Xiaoyi , Liang Xiaowan , Wang Tingting , Guo Yumeng , Liu Te , Xue Jun 
Published: August 2022

Unhealthy diet especially high-fat diet (HFD) is the major cause of hyperlipidemia leading to deterioration of chronic kidney diseases (CKD) in patients. Trimethylamine N-oxide (TMAO) is a gut-derived uremic toxin. Our previous clinical study demonstrated that the elevation of TMAO was positively correlated with CKD progression. Finasteride, a competitive and specific inhibitor of type II 5a-reductase, has been reported recently to be able to downregulate plasma TMAO level thus preventing the onset of atherosclerosis by our research group. In this study, we established a protein-overload nephropathy CKD mouse model by bovine serum albumin (BSA) injection to investigate whether hyperlipidemia could accelerate CKD progression and the underlying mechanisms. Finasteride was administrated to explore its potential therapeutic effects. The results of biochemical analyses and pathological examination showed that HFD-induced hyperlipidemia led to aggravated protein-overload nephropathy in mice along with an elevated level of circulating TMAO, which can be alleviated by finasteride treatment possibly through inhibition of Fmo3 in liver. The 16 S rRNA sequencing results indicated that HFD feeding altered the composition and distribution of gut microbiota in CKD mice contributing to the enhanced level of TMAO precursor TMA, while finasteride could exert beneficial effects via promoting the abundance of Alistipes_senegalensis and Akkermansia_muciniphila. Immunofluorescence staining (IF) and qRT-PCR results demonstrated the disruption of intestinal barrier by decreased expression of tight junction proteins including Claudin-1 and Zo-1 in HFD-fed CKD mice, which can be rescued by finasteride treatment. Cytokine arrays and redox status analyses revealed an upregulated inflammatory level and oxidative stress after HFD feeding in CKO mice, and finasteride-treatment could alleviate these lesions. To summarize, our study suggested that finasteride could alleviate HFD-associated deterioration of protein-overload nephropathy in mice by inhibition of TMAO synthesis and regulation of gut microbiota.
Determining the efficacy of ginger Zingiber officinale as a potential nutraceutical agent for boosting growth performance and health status of Labeo rohita reared in a semi-intensive culture system
Authors: Rawat Priya , Kaur Vaneet Inder , Tyagi Anuj , Norouzitallab Parisa , Baruah Kartik 
Published: August 2022

A 120-day feeding trial was conducted in a pilot field setting to study the nutraceutical properties of ginger powder (GP), focusing on the growth performance and health status of Indian major carp L. rohita reared under a semi-intensive culture system. L. rohita fingerlings (average weight: 20.5 g) were divided into five groups and fed a diet with no GP supplementation (control), or a diet supplemented with GP at 5 g (GP5), 10 g (GP10), 15 g (GP15), and 20 g (GP20) per kg of feed. The study was carried out in outdoor tanks (20 m2) following a complete randomized design with three replicates for each experimental group. Dietary supplementation of GP at 15 g·kg−1 (GP15) of feed caused a significant increase in the growth performances of the fish. Results also showed that feeding of GP15 diet led to a significant improvement in the health status of fish as indicated by a marked change in the tested haematological indices (i.e., higher RBC, WBC, Hb, and Ht values), oxidative status (increased SOD and decreased LPO levels), biochemical parameters (increased HDL, decreased cholesterol, and triglycerides levels), and activities of the liver enzymes (decreased AST and ALT). Overall results suggested that dietary supplementation of GP could positively influence the growth and health status of L. rohita fingerlings, and hence could be an important natural nutraceutical for sustainable farming of carp.
Influence of circulating nesfatin-1, GSH and SOD on insulin secretion in the development of T2DM
Authors: Huang Kangkang , Liang Yunlai , Wang Kun , Wu Jiahui , Luo Huidan , Yi Bin 
Published: August 2022

AimsTo evaluate the correlation of nesfatin-1, GSH and SOD levels with β-cell insulin secretion and their influence on insulin secretion in the development of type 2 diabetes mellitus (T2DM).Materials and methods75 patients with T2DM, 67 with prediabetes and 37 heathy participants were recruited in this study. Serum levels of nesfatin-1, GSH and SOD were quantified and statistically analyzed.ResultsThe levels of nesfatin-1, GSH and SOD in T2DM were significantly decreased (P &lt; 0.001) compared to either in prediabetes or in healthy control, and significant reduction of these biomarkers was also observed in prediabetes when compared to the control (P &lt; 0.001). Circulating nesfatin-1, GSH and SOD were not only strongly correlated with β-cell insulin secretion, but also exerted remarkable influence on the secretion.ConclusionSerum nesfatin-1, GSH and SOD are important factors involving insulin secretion in the development of T2DM, which may help provide new ideas for forthcoming investigations on the roles of these factors in pathogenesis of T2DM, as well as for active prediction and prevention of prediabetes before it develops into overt T2DM.
International Practices on COVID-19 Vaccine Mandates for Transplant Candidates
Authors: Caliskan Yasar , Hippen Benjamin E. , Axelrod David A. , Schnitzler Mark , Maher Kennan , Alhamad Tarek , Lam Ngan N. , Anwar Siddiq , Kute Vivek , Lentine Krista L. 
Published: August 2022

Key Points

The approach to pretransplant coronavirus disease 2019 (COVID-19) vaccination mandates is heterogeneous across different countries and international transplant centers.International and US transplant centers without vaccine mandates cited similar concerns with similar frequencies.Increased public education to overcome vaccine hesitancy worldwide is needed to strengthen acceptance of recommended COVID-19 vaccination among transplant candidates.

Background
The coronavirus disease 2019 (COVID-19) pandemic created unprecedented challenges for solid organ transplant centers worldwide. We sought to assess an international perspective on COVID-19 vaccine mandates and rationales for or against mandate policies.

Methods
We administered an electronic survey to staff at transplant centers outside the United States (October 14, 2021–January 28, 2022) assessing the reasons cited by transplant centers for or against implementing a COVID-19 vaccine mandate. Each responding center was represented once in the analysis.

Results
Respondents (N=90) represented 27 countries on five continents. Half (51%) of responding transplant center representatives reported implementing a COVID-19 vaccine mandate, 38% did not, and 12% were unsure. Staff at centers implementing a vaccine mandate cited efficacy of pretransplant vaccination versus post-transplant vaccination, importance for public health, and minimizing exposure of other patients as rationale for the mandate. Of centers with a mandate, the majority (81%) of the centers mandate vaccination regardless of prior SARS-CoV-2 infection status and regardless of prevaccination spike-protein antibody titer or other markers of prior infection. Only 27% of centers with a vaccine mandate for transplant candidates also extended a vaccine requirement to living donor candidates. Centers not implementing a vaccine mandate cited concerns for undue pressure on transplant candidates, insufficient evidence to support vaccine mandates, equity, and legal considerations.

Conclusions
The approach to pretransplant COVID-19 vaccination mandate policies at international transplant centers is heterogeneous. International transplant centers with a vaccine mandate were more willing to extend vaccine requirements to candidates’ support persons, cohabitants, and living donors. Broader stakeholder engagement to overcome vaccine hesitancy across the world is needed to increase the acceptance of pretransplant COVID-19 vaccination to protect the health of transplant patients.
كفايات الوالدية الصالحة في التصور التربوي الإسلامي
Authors: Fawares Haifa , Al shboul Asma 
Published: August 2022

الأهداف : هدفت هذه الدراسة إلى تحديد منظومة كفايات الوالدية الصالحة من خلال تصور التربية الإسلامية وذلك من خلال استقراء الآيات القرآنية والأحاديث الشريفة و النصوص في المراجع الحديثة.
المنهجية: استخدمت الباحثتان المنهج الوصفي التحليلي من أجل تحقيق هذا الهدف من خلال استقراء الآيات القرآنية و الأحاديث الشريفة و النصوص للتوصل الى تصور واضح للوالدية الصالحة .
النتائج: أظهرت النتائج أن كفايات الوالدية الصالحة هي مجموع القدرات والمهارات والوسائل الأبوية التي تمكن الوالد من إعداد أبنائه وفق منهج الله تعالى، وأن هذه الكفايات تنقسم الى مجالات : - المجال الديني المتمثل باستشعار مسؤولية تربية الأبناء، - المجال الخلقي القائم على امتلاك الصفات الخلقية التي لا يمكن تربية الأبناء تربية صحيحة إلا بوجودها. – والمجال التربوي المتخصص. كما وخلصت الدراسة الى صفات للوالدية الصالحة وهي: - العلم بخصائص نمو الأولاد ومتطلباتها. - العلم باستراتيجيات التربية وأساليبها.
التوصيات: توصي الدراسة بتبني المقترح تضمينه في برامج تدريبية من خلال ورش تدريبية، ودورات فعالة تؤيد الوالدين من أجل التعامل مع أولادهم على نحو حسن، وتربيتهم تربية إسلامية
The Impact of Terrorism on Tourism: Pilot Study 2007–2017: (Case Study of Jordan, Egypt, Spain and France)
Authors: Torki Bani Salameh Mohammed , Hourani Ibraheem 
Published: August 2022

This study discusses the impact of terrorism on tourism from a hypothesis that whenever certain indicators on the Global Scale of Terrorism increase, tourism rates decline. In other words, the escalation of terrorism in a country leads to a decline in its tourist numbers, financial revenue from tourism and the percentage of jobs provided by the tourism sector. The scientific significance of the study is in providing explanatory theorems about the relationship between terrorism and tourism on the one hand, as it endeavors to provide explanatory theorems about various methods, means and measures taken by the countries of the case study to avoid the potential impact of terrorism on their tourism industries, particularly as tourism is one of the most important sources of income for many countries, including the Arab countries. This study uses comparative methodology, case study methodology and quantitative description methodology. The study shows the validity of its premise by conducting a pilot test on the impact of terrorism on several countries in a case study: France, Spain, Egypt and Jordan. The study concludes that, despite the negative impact of terrorism on tourism in the countries in this case study, hidden variables were found that could reduce the negative impact of terrorism on tourism through governmental intervention, such as the programs of diplomatic attraction and promotion, as seen in some countries like France and Jordan, which contributed to the reduction of the negative impact of terrorism on tourism.
An Equal Treatment for Domestic Workers: Qatari Law and International Law
Authors: Mahasneh Nisreen 
Published: August 2022

Objectives: This article aims at studying the rights and obligations of domestic workers under the Qatari Law No. 15/2017 Promulgating the Domestic Workers Law in comparison with the Domestic Workers Convention, 2011 (No. 189) issued by the International Labor Organization (ILO). It also aims at shedding light on the principle of equal treatment between domestic and regular workers, which is fully adopted by the International Convention.
Methods: This study follows a descriptive, analytical and comparative methodology. hence, the legal provisions were reviewed and analyzed, then compared at two levels: comparison between the provisions of the national law on the one hand and the International Convention on the other hand, and comparison between Qatari Law No. (15) relating to domestic workers and the Qatari Employment Law.
Results: The study reached some results, the most important of which is that Qatari law was and still excludes domestic workers from the ambit of the Employment Law; this in turn does not allow applying any of the provisions of the Employment Law to domestic workers, even if it includes a preferential rule. On the other hand, the International Convention aims at achieving equality between regular and domestic workers. The particular law that relates to domestic workers should only apply when it grants an advantage that is not given under Employment Law. That is to say, Employment Law must still be referred to as being the general law.
Conclusions: Qatari legislator should adopt International Convention No. 189, or at least adopt more of its provisions, in order to better approach the principle of equal treatment.
Multiple Comorbidities, Psychiatric Disorders, Healthcare Resource Utilization and Costs Among Adults with Essential Tremor: A Retrospective Observational Study in a Large US Commercially Insured and Medicare Advantage Population
Authors: Dai Dingwei , Samiian Ali , Fernandes Joaquim , Coetzer Henriette 
Published: August 2022

Background: Essential tremor (ET), the most common movement disorder, often impairs patients’ ability to perform activities of daily living, mental health, and quality of life. Objectives: To assess comorbidities, psychiatric disorders, healthcare resource utilization (HCRU), and costs among patients with ET compared with patients without ET. Methods: This retrospective observational study was conducted using a large US administrative claims database. Patients with ET were identified during the study period (1/1/2017–12/31/2019). The earliest claim date with ET diagnosis was identified as the index date. An index date was assigned randomly for each non-ET patient. Patients had to be at least 22 years old and be enrolled in the health plan for at least 6 months before and at least 12 months after the index date. Patients with and those without ET were matched 1:1 on age, gender, payer type, and first 3 digits of their ZIP code. Comorbidities were assessed using data within 6 months prior to the index date. Psychiatric disorders, HCRU, and costs were examined using data within 12 months after the index date. Results: The mean (SD) age of ET patients (n = 5286) was 70.8 (11.8) years, 49.1% were female, and 82.9% were Medicare Advantage members. In the 12 months following the index date, 26.0% of patients had no insurance claims for ET-related pharmacotherapy or invasive therapies. Patients with ET had a higher number of comorbidities than non-ET patients (5.3 [3.2] vs 4.0 [3.3]); a higher prevalence of psychiatric disorders (depression: 25.6% vs 15.3%; adjusted odds ratio (AOR) [95% CI], 1.56 [1.41-1.73]; anxiety: 27.7% vs 15.5%, AOR: 1.78 [1.61-1.96]); and higher total healthcare costs: $17 560 [$39 972] vs $13 237 [$27 098], adjusted cost ratio [95% CI]: 1.11 [1.06-1.16]; all P<.0001. Discussion: Highly prevalent multiple comorbidities and psychiatric disorders should be considered in the context of clinical decision-making to optimize ET management. Conclusions: This study represents the largest observational study to report ET disease and economic burdens in a real-world setting. The data demonstrate increased comorbidity, mental health, and healthcare cost burdens among ET patients compared with matched non-ET patients. These findings underscore the need for innovative care for this complex population.
Ecosistemas tecnológicos mediados por TIC desde la virtualidad para la investigación formativa en contexto
Authors: Cárdenas Espinosa Rubén Darío 
Published: August 2022

Los Ecosistemas Tecnológicos mediados por Tecnologías de Información y Comunicación para la Investigación Aplicada y la Innovación, gestionan el conocimiento generado en los proyectos SENNOVA Centro Metalmecánico y Centro Agroindustrial, los programas de Biología de la Universidad de la Guajira y los programas Tecnológicos de la Facultad de Ingenierías de la Universidad de Caldas, aplicando el B-Learning a través del Modelo PACIE (Presencia, Alcance, Capacitación, Interacción y E-Learning) a través de los Semilleros de Investigación E-InnovaCMM del Centro Metalmecánico Distrito Capital. Los materiales y herramientas empleados son los recursos educativos digitales como Edublosgs, Wiki, Videos, guías didácticas, Mapa de Empatía, Escenarios de Uso, RAE, entre otros. Se ha logrado realizar la divulgación de productos como capítulos de Libro, Artículos Científicos, Recursos Educativos Digitales Multimedia, Virtuales y de Audio, los cuales han servido de modelo para estructurar transferencias tecnológicas para la estructuración de proyectos de investigación aplicada e innovación aplicando metodología de marco lógico, estructuración y divulgación a través de póster y artículo científicos desde los Semilleros de los grupos de Investigación ReNuevaTe Ciencia, Tecnología e Innovación de la Universidad de Caldas, GICEMET del SENA Centro Metalmecánico y BIEMARC de la Universidad de la Guajira y consolidar la producción científica en otros Centros de formación de la Regional Distrito Capital y Quindío. El resultado obtenido es el desarrollo de Recursos Educativos Digitales que han facilitado el aprendizaje significativo de los aprendices vinculados a los semilleros de investigación e innovación. Los resultados obtenidos del proyecto fueron el diseño de prototipos funcionales e iniciativas de proyectos factibles a convertirse en emprendimientos que contribuyan al desarrollo local y regional, la Generación de conocimiento tácito a explícito al interior de SENNOVA fortaleciendo a los 117 grupos de investigación a nivel nacional, el Fortalecimiento de las capacidades de I+D+I de la entidad a través de la apropiación social de conocimiento de la producción científica y académica desarrollada al interior de los grupos de investigación y el desarrollo de una plataforma institucional que permite accede a la memoria institucional de SENNOVA de los últimos 5 años.
Cytokine Filter Experience in Covid-19 Treatment; A Single Center Study
Authors: UĞUZ Mustafa , ATİŞ Şeref Emre 
Published: August 2022

Aim: Several studies state that the primary underlying mechanism of severe COVID-19 cases includes the hyperimmune response triggered following SARS-CoV-2 infections and the subsequent cytokine storm. The study aims to examine the effects of cytokine filters on patients with COVID-19 who developed cytokine storms.
Material and Methods: This is a retrospective, cross-sectional study. All the patients included in the study had tested positive for COVID-19 in their real-time polymerase chain reaction test. The study included patients with COVID-19 who developed cytokine storms and were treated in the ICU. The patients were divided into two groups those who applied cytokine filter or not. The demographic data and laboratory findings of the patients were recorded. The patient outcomes were categorized as discharged or deceased.
Results: The study included 149 patients. Patients’ mean age was 56±29 years, and 125 (83.9%) patients were male. A significant decrease was detected in the levels of fibrinogen, ferritin, lymphocyte count, and CRP after cytokine filtration (p