bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic collapse risk of RC-timber hybrid building with consideration of NBCC 2020 seismic hazard model
Authors: Odikamnoro Ikenna , Badal Prakash S. , Burton Henry , Tesfamariam Solomon 
Published: August 2022

Abstract
The latest seismic hazard model described in the 2020 National Building Code of Canada (NBCC) marks a comprehensive improvement over its predecessor (NBCC 2015). For different regions in Canada, this will have an impact on the design of new buildings and performance assessment of existing ones. In the present study, this impact is quantified for a recently developed hybrid building system of cross-laminated timber (CLT) and reinforced concrete (RC) with steel slit dampers. The six-story CLT-RC dual frame, designed using the direct displacement-based method, is located in Vancouver, Canada. Along with a very high seismicity, southwestern British Columbia is characterized by complex seismotectonics consisting of subduction, shallow crustal, and in-slab faulting mechanisms. With the NBCC 2015 and 2020 models, a hazard-consistent set of 40 pairs of ground motion records is selected from the PEER and KiK-net databases, and used to estimate the building’s seismic risk performance. The collapse capacity of the building reveals the need for the use of site-specific ground motion selection for sites with a complex seismicity. The results also indicate that the combination of CLT and steel slit dampers enhances the seismic performance of the hybrid system. The probability of collapse at a hazard level corresponding to a 2475 year return period event is estimated to be 2.7%.
Recurrent triple-negative breast cancer from cysteine deprivation loses tumorigenicity via downregulation of the CST4 signaling
Authors: Tang Xiaohu , Alothaim Tahiyat , Charbonneau Morgan 
Published: August 2022

Abstract
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a high risk of recurrence following therapeutic treatments. Targeted cysteine therapy via inhibition of cysteine uptake by erastin effectively induces mesenchymal TNBC cells to ferroptosis. However, a small residual population of cancer cells exhibited the erastin-resistance and survived after the erastin treatment. This phenomenon is likely analogous to the event of tumor recurrence in patients after therapy. To characterize this resistance, we established the erastin-resistant/recurrent TNBC cell models in vitro by multi-cycles of erastin challenge. By an epigenetic compound library screen, the erastin-resistance be abolished by adjuvant epigenetic compounds. Intriguingly, the erastin-recurrent TNBC cells failed to grow in anchorage-independent conditions, implying a loss of tumorigenicity. By transcriptomic profiling analysis, the recurrent cells displayed many gene expression alterations and attenuated signaling processes, including K-Ras signaling. Three members of the cystatin gene family, including CST4, were significantly downregulated in recurrent cells. Knocking out of CST4 by CRISPR/Cas9 significantly suppressed the tumorigenic potential and K-Ras signaling. Our findings suggested that targeted cysteine therapy could be a valid treatment for mesenchymal TNBC with a low probability of tumor recurrence.
Evaluation of the long-term endurance of reinforced concrete structures
Authors: Boukari Wadjidou , Abdou-Latif Imorou 
Published: August 2022

Abstract
Even though experts had been monitoring infrastructure quality previous to the COVID-19 epidemic, they had not normally widely highlighted the importance of constructing high-quality infrastructure. The lifespan of a structure is a significant consideration in evaluating how long it will last. This, however, necessitates a reevaluation of infrastructure durability to promote more sustainable growth. Based on these facts, this paper presents a method for measuring building durability utilizing structure deformation effects. The findings indicate that building durability will be acceptable in cities if building deformations in the serviceability state (SLS) do not exceed those of the ultimate limit state (ULS).
Prognostic Value of Lactate/albumin Ratio for Mortality in Patients With Complicated Urinary Tract Infection
Authors: Alberola Juan , Eiros José María , Artero Arturo , Madrazo Manuel , López-Cruz Ian , Piles Laura , Mico Jaume 
Published: August 2022

Abstract
Background
Lactate to albumin ratio (LAR) is an emerging sepsis biomarker that has been tested for mortality in patients with sepsis of different focus. Our goal is to evaluate the prognostic value of LAR in patients admitted to hospital due to complicated urinary tract infection.
Methods
Prospective observational study of patients older than 65 years diagnosed with UTI. Area under the ROC curve, sensibility, and specificity to predict 30-day mortality were calculated for LAR, qSOFA and SOFA and compared.
Results
341 UTI cases were analyzed. 30-day mortality (20.2% vs. 6.7%, p < 0.001) and longer hospital stay (5 [4–8] vs. 4 [3–7], p 0.018) were associated with LAR ≥ 0.708. LAR has no statistically significant differences compared to qSOFA and SOFA for predicting 30-day mortality (AUROC 0.737 vs. 0.832 and 0.777 respectively, p 0.119 and p 0.496). The sensitivity of LAR was similar to the sensitivity of qSOFA and SOFA (60.8% vs. 84.4% and 82.2, respectively, p 0.746 and 0.837). However, its specificity was lower than the specificity of qSOFA (60.8% vs. 75%, p 0.003), but similar to the specificity of SOFA (60.8% vs. 57.8%, p 0.787).
Conclusion
LAR has no significant differences with other well-stablished scores in sepsis, such as qSOFA and SOFA, to predict 30-day mortality in patients with complicated UTI.
Environmental DNA (eDNA) assays for the detection of Ridgway’s Rail (Rallus obsoletus)
Authors: Guan Xin , Lance Richard F. , Feist Sheena M. 
Published: August 2022

Abstract

We designed two novel environmental DNA (eDNA) assays for the detection of Ridgway’s Rail (Rallus obsoletus), and successfully validated each assay using eDNA samples collected from the species’ known distribution within the United States. These assays add to the suite of tools available for the monitoring of this rare and secretive marsh bird, and may help to further elucidate its movement patterns as well as identify important migration corridors. Observed sensitivity of the assays indicates exceptional performance, with limits of detection at ≤ 8 copies of the target eDNA fragment per reaction. Our publication adds to the growing body of literature supporting eDNA surveys as viable tools for bird monitoring endeavors.
Fludarabine/TBI 8 Gy versus fludarabine/treosulfan conditioning in patients with AML in first complete remission: A Study from the Acute Leukemia Working Party of the EBMT
Authors: Bug Gesine , Labopin Myriam , Niittyvuopio Riitta , Stelljes Matthias , Reinhardt Christian , Hilgendorf Inken , Kroeger Nicolaus , Kaare Ain , Bethge Wolfgang , Schaefer-Eckart Kerstin , Verbeek Mareike , Mielke Stephan , Carlson Kristina , Bazarbachi Ali , Spyridonidis Alexandros , Savani Bipin , Nagler Arnon , Mohty Mohamad 
Published: August 2022

Abstract
The optimal reduced intensity conditioning (RIC) regimen is a matter of debate. We retrospectively compared conditioning with fludarabine plus fractionated total body irradiation of 8 Gy (FluTBI) and fludarabine plus treosulfan 30, 36 or 42 g/m2 (FluTreo) in 754 patients with AML above the age of 40 years undergoing an allogeneic hematopoietic stem cell transplant (HSCT) in first complete remission (CR). In a multivariate analysis, FluTBI was associated with a significantly lower probability of relapse than FluTreo (hazard ratio (HR) 0.59 [95% CI, 0.38–0.93], p = 0.023). There was no significant difference in leukemia-free survival (LFS), overall survival (OS), graft-versus-host disease-free and relapse-free survival (GRFS), or acute and chronic graft-versus-host disease (GVHD). After balancing patient characteristics by propensity score matching of 115 patients in each group, FluTBI retained its significantly lower probability of relapse compared to FluTreo (18.3% vs. 34.7%, p = 0.018) which was counteracted by a higher non-relapse mortality (16.8 vs. 5.3%, p = 0.02). Thus, OS and GRFS at 2 years were similar between groups (OS 66.9% vs. 67.8%, GRFS 50.3% vs. 45.6%). We conclude that both conditioning regimens are effective and safe, but FluTBI may better be reserved for younger patients below the age of 55 years.
Spatial and Temporal Effects of Wind Speed on Global Vegetation Growth
Authors: Li Zhiwei , Fu Lijiang , Guo Wei , Song Li , Tan Jinglu , Tang Hao , Xu Zhenyu , Guo Ya 
Published: August 2022

Abstract

Wind effects on vegetation growth have not been examined at the global scale. In this work, the spatial and temporal effects of wind speed on global Solar-induced Chlorophyll Fluorescence (SIF) and Gross Primary Production (GPP) were analyzed. The results show: (1) Spatially, wind has almost the same area percentage (about 12%) of positive influence on SIF (GPP) no matter SIF (GPP) changes or not. Wind itself explains the negative impact more than it does the positive impact. (2) Temporally, there is significant increase in the area percentage (0%~3.9% each year) and magnitude of positive wind effects on SIF and GPP globally for most of vegetation types from 2001 to 2018. (3) Based on SIF and GPP, different types of vegetations enjoy different level of optimal wind speeds. This work provides an overall picture of wind speed effects on vegetation growth globally, and are important for understanding sustainability while climate changes.
Synthesis and Characterization of Composites from Phoenix dactylefera L. Fibers
Authors: BOUGHZEL Abdeslam , LANEZ Touhami , Mya Omar Ben 
Published: August 2022

Abstract
Date palm (Phoenix dactylefera L.) fibers, which are natural wastes, have been recovered and exploited in the synthesis of composite materials by mixing them with two different polymers: polyvinyl chloride (PVC) and polystyrene (PS). The four samples were characterized using infrared spectroscopy (FTIR), water absorption rate (W) measurements, thermal conductivity (λ), and mechanics (tensile stress and stretching at break) testing. The results proved that: (i) At 40°C, the composites absorption rate was higher than at the room temperature. While this rate was better for the composites with non-alkali-treated fibers; (ii) to obtain a thermally insulating composite, polystyrene polymer should be added to the matrix and the alkaline treatment of the used vegetable fibers should be required. (iii) Composites made of non-alkali treated fibers have a high stretching at break values while composites made of alkali-treated fibers have a high tensile stress value.
Selection of Operative Approach in Children with Currarino Syndrome
Authors: Pang Wenbo , Chen Yajun , Wang Kai , Zhang Dan , Qi Xiang , Wu Dongyang 
Published: August 2022

Abstract
Purpose: To summarize the experience of surgical treatment of children diagnosed with Currarino syndrome, with an emphasis on selection of optimal operative approach. Methods: The clinical materials of patients diagnosed with Currarino syndrome were recorded. Special attention was paid to the operative management, particularly the different routes for operation. The type of ARM was the critical point. Follow-up was conducted for at least 3 months, and the Rintala score was used for evaluation of bowel function.Results: The medical records of 26 patients were reviewed and listed in table one. Seven were male, and 19 were female, with a mean age of 19.38±13.80 months (ranging from 2 to 47 months). The anorectal malformation included 17 rectoperineal fistulae without an anus, four rectovestibular fistulae without an anus, two anal stenoses, one anal atresia, one rectourinary fistula without an anus, and one cloaca. The PS was taken in 23 cases. The SPS was taken in eight cases, and LPS was taken in another 15 patients. SPS group included three rectoperineal fistulae without an anus, one anal stenosis, one retraction of the rectum after an anoplasty for rectovestibular fistula without an anus, one anal atresia, one rectourinary fistula without an anus, and one cloaca. In the LPS group, there were 13 perineal fistulae without an anus，one displacement of the rectum and one retraction of the rectum respectively after an anoplasty for rectovestibular fistula without an anus. TA was used in one anal atresia with megacolon and presacral mass. AS was used in one rectovestibular fistula with a presacral mass. A lamina approach was chosen for one patient with an infective fistula secondary to a presacral mass in the spinal canal. The mean follow-up time was 39.48±26.84m, ranging from 6m to 145m. The Rintala score was16.74±2.93, ranging from 12 to 20.Conclusion: For a rectoperineal fistula, SPS or LPS could be used to reach a complete cutback of the posterior wall of the rectum and remove the presacral mass. For a rectovestibular fistula, the AS or LPS could be chosen. For anorectal stenosis, TA, SPS, or LPS could be used to excise the stenosed bowel segment and the presacral mass. TA is not so good for the exposure of the presacral mass, so for a larger one(＞5cm) or one connecting with the spinal canal, the LPS or SPS may be the favorite choice.
Volumetric measurement of intracranial meningiomas: a comparison between linear, planimetric, and machine learning with multiparametric voxel-based morphometry methods
Authors: Silva Jonadab dos Santos , Schreiner Cláudia Abib , de Lima Lázaro , Brigido Carlos Eduardo Pinheiro Leal , Wilson Christopher D , McVeigh Luke , Acchiardo Joseph , Landeiro José Alberto , Acioly Marcus André , Cohen-Gadol Aaron 
Published: August 2022

Abstract
Purpose
To compare the accuracy of three volumetric methods in the radiological assessment of meningiomas: linear (ABC/2), planimetric, and multiparametric machine learning-based semiautomated voxel-based morphometry (VBM), and to investigate the relevance of tumor shape in volumetric error.
Methods
Retrospective imaging database analysis at the authors’ institutions. We included patients with a confirmed diagnosis of meningioma and a volumetric acquired cranial magnetic resonance imaging. After tumor segmentation, images underwent automated computation of shape properties such as sphericity, roundness, flatness, and elongation.
Results
Sixty-nine patients (85 tumors) were included. Tumor volumes were significantly different using linear (13.82 cm³ [range: 0.13–163.74 cm³]), planimetric (11.66 cm³ [range: 0.17–196.2 cm³]) and VBM methods (10.24 cm³ [range: 0.17–190.32 cm³]) (p < 0.001). Median volume and percentage errors between the planimetric and linear methods and the VBM method were 1.08 cm³ and 11.61%, and 0.23 cm³ and 5.5%, respectively. Planimetry and linear methods overestimated the actual volume in 79% and 63% of the patients, respectively. Correlation studies showed excellent reliability and volumetric agreement between manual- and computer-based methods. Larger and flatter tumors had greater accuracy on planimetry, whereas less rounded tumors contributed negatively to the accuracy of the linear method.
Conclusion
Semiautomated VBM volumetry for meningiomas is not influenced by tumor shape properties, whereas planimetry and linear methods tend to overestimate tumor volume. Furthermore, it is necessary to consider tumor roundness prior to linear measurement so as to choose the most appropriate method for each patient on an individual basis.
Anti-neuroinflammatory effects and brain pharmacokinetic properties of selonsertib
Authors: Lee Ji Hun , Ji Sang Hee , Lim Jong Seung , Ahn Sunjoo , Yun Hwi-yeol , Kim Seong Hwan , Song Jin Sook 
Published: August 2022

Abstract
Selonsertib is a first-in-class apoptosis signal-regulating kinase 1 (ASK1) inhibitor that was in clinical trials for treatment of NASH and diabetic kidney disease due to its anti-inflammatory and anti-fibrotic activities. In the present study, we investigated the anti-neuroinflammatory effects and brain pharmacokinetic properties of selonsertib. It inhibited TNF-α and NO production by suppression of phosphorylated ASK1 in the LPS-stimulated microglial cell line, BV2 cells. Consistent with the in vitro results, selonsertib attenuated plasma and brain TNF-α levels in the LPS-induced murine neuroinflammation model. In vitro and in vivo pharmacokinetic studies of selonsertib were conducted in support of central nervous system (CNS) drug discovery. In both Caco-2 and MDR-MDCK cells, selonsertib exhibited a high efflux ratio, showing that it is a P-gp substrate. Selonsertib was rapidly and effectively absorbed into the systemic circulation after oral treatment, with a Tmax of 0.5 h and oral bioavailability of 74 %. In comparison with high systemic exposure with Cmax of 16.2 µg/ml and AUC of 64 µg·h/mL following oral dosing of 10 mg/kg, the brain disposition of selonsertib was limited, with Cmax of 0.08 µg/g and Kp value of 0.004. This study demonstrates that selonsertib has the potential to be used as a therapeutic agent for neuroinflammatory diseases.
Comparison of Malignancy and Spatial Distribution between Latent and Clinical Prostate Cancer--an eight-year biopsy study
Authors: Liang Zhen , Zhou Zhien , Huang Hanzi , Wu Xingcheng , Xiao Yu , Wang Wenze , Zuo Yuzhi , Chen Yuliang , Zhou Yi , Yan Weigang 
Published: August 2022

Abstract
BackgroundCurrent prostate cancer (PCa) screening may detect nonprogressive lesion, leading to overdiagnosis and overtreatment. The purpose of present study is to investigate whether the tumor pathological origin of latent prostate cancer (lPCa) and clinical prostate cancer (cPCa) is consistent, and to verify the current clinically significant prostate cancer criteria.Methods:Prostate specimens were obtained from postmortem autopsy between 2014 and 2021 and patients who went through radical prostatectomy from 2013 to 2021. The pathological characteristics and spatial distribution of the lPCa group and cPCa were compared and analyzed through SPSS software with P < 0.05 representing statistical significant. ResultsIn lPCa group, a total of 45 tumor lesions from 24 lPCa cases were included, 54.2% of lPCa patients were ISUP ≥ 2, 12.5% had tumor volume ≥ 0.5 ml, and 16.7 % had extraprostatic extension (EPE). In cPCa group, there were a total of 429 tumor lesions in 126 cases, 92.1% of cPCa patients were ISUP ≥ 2, and 82.5% had tumor volume of ≥ 0.5ml. 56.3% had EPE. LPCa and cPCa have the same spatial distribution characteristics, no significant difference was detected between the anterior and posterior zone. Peripheral zone tumors were significantly more common than transitional zone tumors. Tumors in apical 1/3 and middle 1/3 were significantly more common than basal 1/3. ConclusionThe malignancy of cPCa is significantly higher than that of lPCa, and the spatial distribution of cPCa and lPCa are consistent. ISUP grade 2 is not sufficient to determine clinical significance of tumor.
Workload Indicators of Staffing Need (WISN) Method for
Authors: Asres Gizew Dessie 
Published: August 2022

Abstract
Background
Work force is a crucial component of health services delivery system. Ethiopia faces health workforce challenges with regard to evidence based health work force planning. First the health worker to population ratio was used and later standard staffing schedule for each health facility level was used. Both of these methods did not address the issue of evidence based workload variation between the same levels of facilities at different locations within a country. A workload indicator of staffing need method (WISN) addresses these variations. Therefore this study was assumed for recommendation on use of WISN for health facilities based on WISN results of midwives at Asrade Zewude memorial Hospital.
Methods
Cross sectional study using WISN model was used to determine the gaps or excess and workload pressure in midwives at Asrade Zewude Memorial primary hospital, North West Ethiopia.
Results
The finding showed that there was five working days with 1030 hrs actual working time per year for midwives. This working time was spent on health service activities (58.4%), additional activities (36.6%) and support activities (5%). WISN calculation showed that a shortage of five midwives with WISN ratio of 0.8 at Asrade Zewude Memorial primary hospital North West Ethiopia.
Conclusion
Midwives at the study area were doing their routine work with 20% under staffed by covering the additional five midwives' position. With this working condition, it may be hard to achieve universal health coverage goals of the facility. Therefore the hospital should institutionalize WISN method to objectively employ midwifery professionals.
Exploring Natura 2000 Habitats by Satellite Image Segmentation: a case study from the Čierny Balog area (Central Slovakia)
Authors: Čahojová Lucia , Ambroz Martin , Jarolímek Ivan , Kollár Michal , Mikula Karol , Šibík Jozef , Šibíková Mária 
Published: August 2022

Abstract
Natura 2000 is a network of protected areas covering Europe's most valuable and threatened species and habitats. Recently, biota belonging to these networks have been threatened by both climate change and various human impacts. Regular monitoring is needed to ensure effective protection and proper management measures in these sites and habitats, but conventional field approaches are often time-consuming and inaccurate. New approaches and studies with different focuses and results are being developed. Our approach includes point data from field research and phytosociological databases as starting points for automatic segmentation, which has been developed just recently as a novel method that could help to connect ground-based and remote sensing data. The main aim of our case study is to apply advanced remotely sensed techniques to map the area and condition of vegetation units. We focus on forest habitats belonging mainly to the Natura 2000 network in the area of Čierny Balog village (Central Slovakia). We concentrated on the verification of the possibilities of differentiation of various habitats using only multispectral Sentinel-2 satellite data. New software created by our team called NaturaSat was used to reach our objectives. In the identified areas, spectral characteristics were calculated using software tools, which were subsequently processed and tested statistically. We obtained significant differences between forest habitat types that provided promising results and verification of the methods used. This type of new habitat identification is necessary for the automatic monitoring of habitat areas and changes in conditions by remote sensing.