bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remarkable recoveries: an interpretation of recovery narratives using the CHIME model
Authors: Hurst Robert , Carson Jerome , Shahama Aishath , Kay Hollie , Nabb Courtney , Prescott Julie 
Published: February 2022

Purpose
The purpose of this paper is to review the 16 published non-student Recovery Heroes and Remarkable Lives accounts published in Mental Health and Social Inclusion, using the connection, hope, identity, meaning and empowerment (CHIME) framework.

Design/methodology/approach
All 16 accounts were rated independently by four researchers and evaluated in terms of whether each account met the five criteria for the CHIME model.

Findings
All accounts met the criteria for the CHIME model, with the exception of one, which still met four of the five criteria. Evidence was presented which suggests that the model can be extended to creativity, connectedness, hope, identity, meaning and empowerment (C-CHIME), to incorporate creativity.

Research limitations/implications
While a certain level of subjectivity is required in deciding how each account meets the CHIME criteria, there were high levels of inter-rater reliability within the research team. Creativity had a central place in all the accounts.

Practical implications
The revised C-CHIME model can be used by practitioners to examine accounts of recovery in a more focussed manner and may also help in devising recovery action plans.

Social implications
The recovery model privileges both professional and lived experience perspectives on recovery. The current review highlights how much we can benefit from the wisdom contained in first person accounts.

Originality/value
This review adds to the existing literature and highlights the importance of creativity for mental health recovery.
High ownership concentration and income shifting in multinational groups
Authors: Medioli Alice , Azzali Stefano , Mazza Tatiana 
Published: February 2022

Purpose
Prior literature shows that income shifting is widely performed by multinational groups, but no research as yet has studied alignment between controlling and minority interests on tax avoidance in multinational groups with high ownership concentration. This study aims to analyze the effect of high ownership concentration on cross-jurisdictional tax-motivated income shifting.

Design/methodology/approach
To test the hypotheses, this study focuses on European multinational groups. Data are collected on European parent firms and each subsidiary. The model considers the natural logarithm of profit before tax and tax incentive.

Findings
Findings show that subsidiaries shift income for tax avoidance purposes. The alignment of shareholders’ interests and ownership concentration leads to higher levels of tax avoidance through subsidiaries’ infra-group transactions. High ownership concentration decreases the influence of minority interests and allows parent company shareholders to choose a tax avoidance strategy more freely.

Practical implications
The results suggest that taxation levels need to be harmonized to reduce the incentive for tax avoidance and the incentive of governments to reduce their statutory tax rate, to shift profits inwards and reduce outward flow. Without international coordination, this approach may lead to the unevenness of legislative frameworks around the world, and bring significant disadvantages for some countries, influencing economic growth and business development.

Originality/value
This study extends prior findings showing that tax-motivated income shifting as a method of tax avoidance in European multinational groups is stronger in groups with high levels of ownership concentration. This means that managers have the incentive to shift income between subsidiaries for tax and ownership benefits in favor of the parent company’s shareholders and against minority interests.
Scale dependence of landscape heterogeneity effects on plant invasions
Authors: Kotowska Dorota , Pärt Tomas , Skórka Piotr , Auffret Alistair G. , Żmihorski Michał 
Published: February 2022

Abstract

Invasive alien species are among the most concerning threats to native biodiversity world‐wide, and the level of landscape heterogeneity is considered to affect spatial patterns of their occurrence and spread. However, as previous studies on these associations report contrasting results, the role of landscape heterogeneity on its susceptibility to invasions remains poorly understood. Landscape heterogeneity is usually described by two measures: configuration and composition. Both measures may differently affect invasive species and these impacts may be additionally scale dependent. Nevertheless, their relative contribution to invasion patterns is poorly known.

We investigated the effect of two landscape heterogeneity components: configuration (edge density) and composition (number and evenness of land cover types) measured at different spatial scales (from within 0.25 to 5 km of the studied locations) on the local abundance of one of the most invasive alien plant species in Europe, the North American goldenrods (Solidago canadensis and S. gigantea). Using publicly available geospatial environmental data and a novel method based on remote analysis of Google Street View images, we collected and analysed large dataset on goldenrod occurrence along 1,347 roadside transects in agricultural landscapes of Poland.

Both the compositional and configurational heterogeneity were positively associated with the local abundance of goldenrods, however, the effect size of these relationships was dependent on spatial scale. While abundance–heterogeneity associations were most pronounced at the largest spatial scale for compositional heterogeneity, the pattern was the opposite for configurational heterogeneity.

Synthesis and applications. Landscape heterogeneity is a clear correlate of plant invasion potential, with occurrences of invasive plants generally higher in more heterogeneous landscapes. However, scale dependence of this association means that researchers and practitioners may miss the association if only concentrating on a single spatial scale. While increasing heterogeneity of rural landscapes is widely introduced as a way to promote farmland biodiversity, we show that it may also support invasive plants, and thus conflict with original goals of biodiversity‐oriented strategies. Therefore, we suggest implementing regular management and eradication schemes in most heterogeneous landscapes. Finally, we demonstrate how remote analysis of plant invasions using existing imagery can advance our understanding of invasion biology.
The pH signalling transcription factor PacC modulate growth, development, stress response and pathogenicity of Trichothecium roseum
Authors: Wang Bin , Han Zhanhong , Gong Di , Xu Xiaobin , Li Yongcai , Sionov Edward , Prusky Dov , Bi Yang , Zong Yuanyuan 
Published: February 2022

SummarypH is one of the important environmental factors that affect the growth, development and pathogenicity of postharvest pathogen. The transcription factor PacC dominates the pH signal pathway. PacC in Trichothecium roseum showed three typical conserved zinc finger domains and closest homology to Fusarium graminearum. T. roseum increased the environmental pH both in vitro and in vivo. Expression patterns of TrpacC under different pH showed that at increasing pH from 3 to 5, the wild‐type (WT) strain induced the expression of TrPacC in parallel to increased fungal growth; however, TrPacC expression decline at higer pH than 5, while fungal growth continued to increase. Development of a ΔTrPacC mutant down‐regulated the expression of TrbrlA, TrabaA and TrwetA, reduced sporulation and delayed spore germination, resulting in smaller spores and sparse hyphae. ΔTrPacC mutant was sensitive to ionic stress, oxidative stress and cell wall integrity stress compared to the WT strain, especially the ionic stress. In addition, ∆TrPacC mutant showed reduced pathogenicity to muskmelon and tomato fruits. Taken together, T. roseum is an alkalinizing fungus, and the acidic environment could induce TrPacC expression. TrPacC positively regulates fungal growth and development as well as pathogenicity showing effect on fungal response to different stresses.
Painful and sometimes deadly experiments which Nazi doctors carried out on children
Authors: Weindling Paul 
Published: February 2022

AbstractCoerced human experiments are among the most disturbing forms of ethical violations and criminality in medicine under National Socialism. Until 2016, there was no evidence‐based analysis concerning numbers of victims and the type of experiments. A reference resource on Victims of Biomedical Research under NS. Collaborative Database of Medical Victims currently covers 28 655 victims who were subjected to 359 different experiments by the Nazis during World War Two. Drawing on this resource, this paper focuses on research on children. Finally, the narrow focus on the experiments, highlighting scientific methodology but disregarding the killing procedures of the Holocaust, is critically analysed.
The cause of eyelid ptosis, orthostatic hypotension and exercise intolerance
Authors: Monnens Leo 
Published: February 2022

AbstractTo provide more insight in the delay in diagnosis and expectation of treatment adapted for the paediatrician, the data were collected from patients described with dopamine beta‐hydroxylase deficiency are evaluated. More insight in clinical features of dopamine beta‐hydroxylase deficiency consisting mainly of eyelid ptosis, orthostatic hypotension, hypoglycaemia and exercise intolerance, explains the delay in diagnosis of this congenital disorder, although all symptoms some more concealed are present. An increasing experience by L‐DOPS, a resurrection for the patient, allows recommendations for early treatment. An explanation for the delay in diagnosis is provided together with the advice for treatment.
Laparoscopic resection for a relapsed presacral epidermoid cyst penetrating the ischiorectal fossa
Authors: Sakurai Tsubasa , Mukai Toshiki , Kawachi Hiroshi , Hiyoshi Yukiharu , Yamaguchi Tomohiro , Nagasaki Toshiya , Akiyoshi Takashi , Fukunaga Yosuke 
Published: February 2022

AbstractAn epidermoid cyst occurring in the presacral region is a rare congenital cystic tumor. Complete surgical excision is recommended because of the possibility of infection and malignancy. Depending on the size and location, several approaches, such as anterior, posterior, combined, and laparoscopic approaches, have been described. Here, we have reported a rare case of relapsed epidermoid cyst after emergency laparotomy and transvaginal drainage. Although the cyst penetrated the levator ani muscle and was densely adhered to the vagina and rectum, complete laparoscopic resection was successfully performed. This approach is a useful technique as it is minimally invasive and minimizes tissue destruction of the pelvic floor.
The German Logic of Emancipation and Biesta's Criticism of Emancipatory Pedagogy
Authors: Moilanen Antti , Huttunen Rauno 
Published: February 2022

ABSTRACTGert Biesta has criticized Anglo‐American and German models of emancipatory education. According to Biesta, emancipation is understood in these models as liberation that results from a process in which a teacher transmits objective knowledge to his or her students and cultivates student capabilities. He claims that this so‐called modern logic of emancipation does not lead to freedom because it installs inequality, dependency, and mistrust in the pedagogical relationship. In this article, Antti Moilanen and Rauno Huttunen analyze whether German models of emancipatory education share the modern logic of emancipation and if they can escape Biesta's criticisms. For this purpose, they interpret Biesta's critique of the modern logic of emancipation and explicate central ideas related to the German models of critical education. They also compare the modern logic of emancipation to the German one, and they then assess German models of emancipatory pedagogy from the viewpoint of Biesta's criticisms. Moilanen and Huttunen conclude that the German models of emancipatory education present at least a partial alternative to the modern logic of emancipation. Despite this, the German models are based on the idea of education as cultivation. Because Biesta criticizes the theory of education as cultivation, it is possible to conclude that he would not accept the German models of emancipatory education. However, the German models of critical pedagogy provide answers to the following question: how can students achieve independence in the pedagogical relationship? When students take part in designing educational processes, they are summoned to assess the validity of the taught knowledge, and they practice independent decision‐making at school; the pedagogical relationship, based on authority, can foster student self‐determination.
Stigma, sustainability, and capitals: A case study on the menstrual cup
Authors: Owen Lara 
Published: February 2022

AbstractThis paper develops theory on stigma, capitals, and the female reproductive body, explored through analysis of empirical research on the uptake of menstrual cups, a reusable menstrual technology. Conventional menstrual products are single‐use disposables increasingly made of plastic and often disposed of by flushing, adding a significant load to marine pollution. Uptake of reusable products such as cloth pads, period underwear, and menstrual cups is increasing, but so far little is known about the effects of using such products on menstruators and on menstrual organization more broadly. My empirical research studied menstrual cup use in a small cohort of undergraduates in Melbourne, using a dual diary and interview technique. “Sustainability” as a key value was primary in participants' desire to try the cup, which most then found to be more convenient than other methods. These factors contributed to increased cultural capital surrounding menstruation, to the point where the cup and its use were described as “cool”. This new status facilitated articulation of menstrual experience with partners, peers, and families, rendering users greater agency and community in what has normatively been constructed as a solitary, silenced experience. Using the cup detached users from the menstrual disposability market economy, and therefore to some extent from its stigmatizing narrative and symbolic violence. Yet the cup had a significant paradoxical effect, in that users were able to “forget” they were menstruating during the day and in organizational settings, while encountering menstrual blood more intensely when they got home, differently enclosing the female reproductive body.
Macrophage metabolism in the intestine is compartment specific and regulated by the microbiota
Authors: Scott Nicholas A. , Lawson Melissa A. E. , Hodgetts Ryan James , Le Gall Gwénaëlle , Hall Lindsay J. , Mann Elizabeth R. 
Published: February 2022

AbstractIntestinal macrophages play a vital role in the maintenance of gut homeostasis through signals derived from the microbiota. We previously demonstrated that microbial‐derived metabolites can shape the metabolic functions of macrophages. Here, we show that antibiotic‐induced disruption of the intestinal microbiota dramatically alters both the local metabolite environment and the metabolic functions of macrophages in the colon. Broad‐spectrum antibiotic administration in mice increased the expression of the large neutral amino acid transporter LAT1 and accordingly, amino acid uptake. Subsequently, antibiotic administration enhanced the metabolic functions of colonic macrophages, increasing phosphorylation of components of mammalian/mechanistic target of rapamycin signalling pathways, with increased expression of genes involved in glycolysis and oxidative phosphorylation (OXPHOS), increased mitochondrial function, increased rate of extracellular acidification (ECAR; measure of glycolysis) and increased rate of oxygen consumption (OCR; measure of OXPHOS). Small bowel macrophages were less metabolically active than their colonic counterparts, with macrophage metabolism in the small intestine being independent of the microbiota. Finally, we reveal tissue‐resident Tim4+ CD4+ macrophages exhibit enhanced fatty acid uptake alongside reduced fatty acid synthesis compared to recruited macrophages. Thus, the microbiota shapes gut macrophage metabolism in a compartment‐specific manner, with important implications for monocyte recruitment and macrophage differentiation.
Investigating information and communication technology‐enabled national development as a multi‐level social process
Authors: Ramadani Luthfi , Breidbach Christoph F. , Kurnia Sherah 
Published: February 2022

AbstractAre centralised or decentralised strategies more suitable to address a developing nation's socio‐economic challenges through information and communication technology (ICT)? We respond to this long‐standing question by conceptualising ICT‐enabled national development as a multi‐level social process and by drawing on empirical findings from a natural experiment set in the context of health information system projects in Indonesia. Our study demonstrates that successful ICT‐enabled national development is not contingent on pursuing one strategy or the other but on how micro‐level actors interpret, and subsequently respond to, these strategies and the local changes they trigger. Our findings indicate that centralisation and decentralisation are complementary rather than competing strategies to ICT‐enabled national development because, if integrated into a hybrid strategy, decentralisation enables local communities to achieve national development outcomes commonly attributed to centralisation. As such, our work provides empirical evidence, explanations and new theoretical insight into the wider ‘centralisation versus decentralisation’ debate, while also outlining avenues for future research and guidelines for policymakers.
Random regression test‐day models to describe milk production and fatty acid traits in first lactation Walloon Holstein cows
Authors: Paiva José Teodoro , Mota Rodrigo Reis , Lopes Paulo Sávio , Hammami Hedi , Vanderick Sylvie , Oliveira Hinayah Rojas , Veroneze Renata , Fonseca e Silva Fabyano , Gengler Nicolas 
Published: February 2022

AbstractWe investigated the use of different Legendre polynomial orders to estimate genetic parameters for milk production and fatty acid (FA) traits in the first lactation Walloon Holstein cows. The data set comprised 302,684 test‐day records of milk yield, fat and protein contents, and FAs generated by mid‐infrared (MIR) spectroscopy, C16:0 (palmitic acid), C18:1 cis‐9 (oleic acid), LCFAs (long‐chain FAs), SFAs (saturated FAs) and UFAs (unsaturated FAs) were studied. The models included random regression coefficients for herd‐year of calving (h), additive genetic (a) and permanent environment (p) effects. The selection of the best random regression model (RRM) was based on the deviance information criterion (DIC), and genetic parameters were estimated via a Bayesian approach. For all analysed random effects, DIC values decreased as the order of the Legendre polynomials increased. Best‐fit models had fifth‐order (degree 4) for the p effect and ranged from second‐ to fifth‐order (degree 1–4) for the a and h effects (LEGhap: LEG555 for milk yield and protein content; LEG335 for fat content and SFA; LEG545 for C16:0 and UFA; and LEG535 for C18:1 cis‐9 and LCFA). Based on the best‐fit models, an effect of overcorrection was observed in early lactation (5–35 days in milk [DIM]). On the contrary, third‐order (LEG333; degree 2) models showed flat residual trajectories throughout lactation. In general, the estimates of genetic variance tended to increase over DIM, for all traits. Heritabilities for milk production traits ranged from 0.11 to 0.58. Milk FA heritabilities ranged from low‐to‐high magnitude (0.03–0.56). High Spearman correlations (>0.90 for all bulls and >0.97 for top 100) were found among breeding values for 155 and 305 DIM between the best RRM and LEG333 model. Therefore, third‐order Legendre polynomials seem to be most parsimonious and sufficient to describe milk production and FA traits in Walloon Holstein cows.
Serum nuclear factor E‐2‐related factor 2 in female pattern hair loss
Authors: Bakry Ola A. , Sobhy S. , Essam El Deen M. , Seleit I. 
Published: February 2022

AbstractBackgroundFemale pattern hair loss (FPHL) is a common dermatological complaint with multifactorial etiology. Nuclear factor erythroid‐2‐related factor 2 (NRF2) is a transcription factor that has a major role in protection from ROS‐induced apoptosis.AimTo investigate the relationship between Nrf2 and systemic oxidative stress in FPHL patients.Patients and MethodsThis case–control study included 30 patients with FPHL and 30 age‐ and sex‐matched healthy volunteers as a control group. Serum NRF2, total antioxidant capacity (TAC), and total oxidant capacity (TOC) were measured by ELISA, and oxidative stress index (OSI) was calculated.ResultsThe serum level of TOC and OSI was found to be significantly higher (p ≤ 0.001 for both) while serum level of NRF2 and TAC was found to be significantly lower in cases than controls (p < 0.001 for both). There were a significant negative correlation between TAC and BMI (p = 0.03, r = −0.391) and a significant positive correlation between OSI and BMI (p = 0.04, r = 0.365). There were a significant positive correlation between serum level of NRF2 and TAC (p = 0.003, r = 0.532) and a significant negative correlation between serum the level of NRF2 and TOC (p = 0.02, r = −0.418) and OSI (p = 0.003, r = −0.395).ConclusionSystemic oxidative stress in FPHL may be, at least in part, due to NRF2 deficiency. NRF2 activators may help in treatment of this disease. NRF2 deficiency has no role in disease severity. Healthy diet and body weight reduction may help in improving oxidative stress and subsequently improving FPHL.
Changing landscape of dialysis withdrawal in patients with kidney failure: Implications for clinical practice
Authors: Chen Jenny H. C. , Lim Wai H. , Howson Prue 
Published: February 2022

AbstractDialysis withdrawal has become an accepted treatment option for patients with kidney failure and is one of the leading causes of death in patients receiving dialysis in high‐income countries. Despite its increasing acceptance, dialysis withdrawal currently lacks a clear, consistent definition. The processes and outcomes of dialysis withdrawal have wide temporal and geographical variability, attributed to dialysis patient selection, influence from cultural, religious and spiritual beliefs, and availability of kidney replacement therapy and conservative kidney management. As a complex, evolving process, dialysis withdrawal poses an enormous challenge for clinicians and healthcare teams with various limitations precluding a peaceful and smooth transition between active dialysis and end‐of‐life care. In this review, we examine the current definitions of dialysis withdrawal, the temporal and geographical patterns of dialysis withdrawal, international barriers in the decision‐making process (including dialysis withdrawal during the COVID‐19 pandemic), and gaps in the current dialysis withdrawal recommendations for clinical consideration and future studies.