bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune response and safety to inactivated COVID-19 vaccine: a comparison between people living with HIV and HIV-naive individuals
Authors: Zou Shi , Wu Mengmeng , Ming Fangzhao , Wu Songjie , Guo Wei , Marley Gifty , Xing Zhongyuan , Zhang Zhiyue , Zeng Minxia , Sun Chao , Zhang Jianfeng , Tang Weiming , Liang Ke 
Published: July 2022

Abstract
Background
Multi-types COVID-19 vaccines have shown safety and efficacy against COVID-19 in adults. Although current guidelines encourage people living with HIV (PLWH) to take COVID-19 vaccines, whether their immune response to COVID-19 vaccines is distinct from HIV-free individuals is still unclear.

Methods
Between March to June 2021, 48 PLWH and 40 HNC, aged 18 to 59 years, were enrolled in the study in Wuchang district of Wuhan city. All of them received inactivated COVID-19 vaccine (Sinopharm, WIBP-CorV, Wuhan Institute of Biological Products Co. Ltd) at day 0 and the second dose at day 28. The primary safety outcome was the combined adverse reactions within 7 days after each injection. The primary immunogenicity outcomes were SARS-CoV-2 neutralizing antibodies (nAbs) responses by chemiluminescence and total specific IgM and IgG antibodies responses by ELISA and colloidal gold at baseline (day 0), day 14, day 28, day 42, and day 70.

Results
In total, the study included 46 PLWH and 38 HNC who finished 70 days’ follow-up. The frequency of adverse reactions to the first and second dose was not different between PLWH (30% and 11%) vs. HNC (32% and 24%). NAbs responses among PLWH peaked at day 70, while among HNC peaked at day 42. At day 42, the geometric mean concentration (GMC) and seroconversion rate of nAbs among PLWH were 4.46 binding antibody units (BAU)/mL (95% CI 3.18–5.87) and 26% (95% CI 14–41), which were lower than that among HNC [GMC (18.28 BAU/mL, 95% CI 10.33–32.33), seroconversion rate (63%, 95% CI 44–79)]. IgG responses among both PLWH and HNC peaked at day 70. At day 70, the geometric mean ELISA units (GMEU) and seroconversion rate of IgG among PLWH were 0.193 ELISA units (EU)/mL (95% CI 0.119–0.313) and 51% (95% CI 34–69), which was lower than that among HNC [GMEU (0.379 EU/mL, 95% CI 0.224–0.653), seroconversion rate (86%, 95% CI 64–97)]. There were no serious adverse events.

Conclusions
Early humoral immune response to the inactivated COVID-19 vaccine was weaker and delayed among the PLWH population than that among HNC. This observation remained consistent regardless of a high CD4 count with effective antiretroviral therapy.
Dietary protein intake during pregnancy and birth weight among Chinese pregnant women with low intake of protein
Authors: Yang Jiaomei , Chang Qianqian , Tian Xueye , Zhang Binyan , Zeng Lingxia , Yan Hong , Dang Shaonong , Li Yue-Hua 
Published: July 2022

Abstract
Background
Previous studies have yielded inconsistent results on the association between maternal dietary protein intake and birth weight. Moreover, little is known about the effects of dietary protein intake from different sources on fetal growth. This study aimed to investigate the associations of different dietary protein sources (total protein, animal protein, plant protein, and major dietary protein sources) during pregnancy with birth weight and the related adverse birth outcomes.

Methods
7310 women were recruited using a stratified multistage random sampling method at 0–12 months (median: 3; 10–90th percentile: 0–7) after delivery in Shaanxi, China. Maternal diets were gathered by a validated FFQ and other characteristics were collected by a standard questionnaire. Multilevel linear or logistic regression models were used to estimate birth weight changes or ORs (95% CIs) for adverse birth outcomes associated with different dietary protein sources during pregnancy.

Results
The mean percentage of energy from total protein was 11.4% (SD 2.2), with only 27.4% of total protein derived from animal protein. Per 3% increase in energy from total protein, animal protein, and dairy protein was associated with birth weight increases of 19.4 g (95% CI 6.0–32.9), 20.6 g (4.8–36.5), and 18.2 g (4.7–31.7), respectively. Per 3% increase in energy from total protein, animal protein, and dairy protein was also associated with lower risks of low birth weight (LBW) (total protein: OR = 0.78, 95% CI 0.64–0.94; animal protein: 0.79, 0.65–0.96; dairy protein: 0.71, 0.56–0.91), small for gestational age (SGA) (total protein: 0.88, 0.79–0.98; animal protein: 0.87, 0.78–0.97; dairy protein: 0.81, 0.68–0.96), and intrauterine growth retardation (IUGR) (total protein: 0.84, 0.72–0.98; animal protein: 0.86, 0.75–0.98; dairy protein: 0.78, 0.66–0.92). We observed no associations of plant protein and other major dietary protein sources with birth weight and the above birth outcomes. The results did not change when maternal protein was substituted for fat or carbohydrate.

Conclusions
Among Chinese pregnant women with low intake of protein, higher intake of dietary protein, in particular animal protein and dairy protein, is associated with higher birth weight and lower risks of LBW, SGA, and IUGR.
Stereotactic body radiotherapy extends the clinical benefit of PD-1 inhibitors in refractory recurrent/metastatic nasopharyngeal carcinoma
Authors: Lin Jing , Guo Qiaojuan , Guo Zengqing , Lu Tianzhu , Chen Gang , Lin Shaojun , Chen Mei , Chen Chuanben , Lu Jianping , Zong Jingfeng , Tang Lina , Chen Yu , Pan Jianji 
Published: July 2022

Abstract
Purpose
Emerging evidence shows that immune checkpoint inhibitors lead to durable responses in a variety of cancers, including nasopharyngeal carcinoma (NPC), however, combination approaches (i.e., stereotactic body radiation therapy, SBRT) are required to extend this benefit beyond a subset of patients. This study retrospectively evaluated eight recurrent/metastatic NPC patients, to investigate how radiation could potentiate PD-1 checkpoint inhibition therapy.

Methods
Between September 2016 and July 2017, eight consecutive cases with histologically confirmed PDL1-positive status, for which prior standard therapy had been ineffective (five patients), were treated at our institution and Macao Clinics and two patients had disease progression within 6 months of completion of definitive chemoradiation, or one patient refused to receive chemoradiotherapy. All received PD-1 inhibitors first, seven of them accepted SBRT with an unmodified PD-1 inhibitors regimen after first evaluation as they were unresponsive to PD-1 inhibitors alone. Treatment was discontinued as long as patients were experiencing a clinical benefit in the opinion of the physicians and at least five cycles were given before stoppage.

Results
Median follow-up time was 56.7 months. The confirmed objective response rate based on RECIST-v1.1 at first evaluation was 12.5% (1/8). For the seven cases who received SBRT, six of them experience an objective response (6/7, 85.7%) after SBRT. Only one patient showed rapid progress and die within 95 days after the initiation of SBRT intervention. Three patients who did not have all lesions exposed to irradiation were available to evaluate the incidence of an abscopal effect, however, it did not occur as expected. Median PFS and OS for the seven patients were 8.0 and 30.8 months after SBRT intervention, respectively. Two-year OS as indicated was 71.0%.

Conclusions
PD-1 inhibitors combined with SBRT demonstrated promising antitumor activity in patients with PD-L1 positive RM-NPC. Patients may benefit from continue immunotherapy beyond disease progression when SBRT was introduced.
Minos: variant adjudication and joint genotyping of cohorts of bacterial genomes
Authors: Hunt Martin , Letcher Brice , Malone Kerri M. , Nguyen Giang , Hall Michael B. , Colquhoun Rachel M. , Lima Leandro , Schatz Michael C. , Ramakrishnan Srividya ,   CRyPTIC consortium, Iqbal Zamin 
Published: July 2022

AbstractThere are many short-read variant-calling tools, with different strengths and weaknesses. We present a tool, Minos, which combines outputs from arbitrary variant callers, increasing recall without loss of precision. We benchmark on 62 samples from three bacterial species and an outbreak of 385 Mycobacterium tuberculosis samples. Minos also enables joint genotyping; we demonstrate on a large (N=13k) M. tuberculosis cohort, building a map of non-synonymous SNPs and indels in a region where all such variants are assumed to cause rifampicin resistance. We quantify the correlation with phenotypic resistance and then replicate in a second cohort (N=10k).
On secrecy outage probability for downlink NOMA systems with relay–antenna selection
Authors: Xu Shu , Liu Chen , Wang Hong , Qian Mujun , Sun Wenfeng 
Published: July 2022

AbstractSecure transmission is essential for future non-orthogonal multiple access (NOMA) system. This paper investigates relay–antenna selection to enhance physical-layer security of cooperative NOMA system in the presence of an eavesdropper, where multiple antennas are deployed at the relays, the users, and the eavesdropper. In order to reduce expense on radio frequency chains, selection combining (SC) is employed at both the relays and the users, whilst the eavesdropper employs either maximal-ratio combining or SC to process the received signals. Under the condition that the channel state information of the eavesdropping channel is available or unavailable, two effective relay–antenna selection schemes are proposed. Additionally, the closed-form expressions of secrecy outage probability (SOP) are derived for the proposed relay–antenna selection schemes. In order to gain more deep insights on the derived results, the asymptotic performance of the derived SOP is analyzed. In simulations, it is demonstrated that the theoretical results match well with the simulation results and the SOP of the proposed schemes is less than that of the conventional orthogonal multiple access scheme obviously.
Fasciola spp. in Southeast Asia: a systematic review and meta-analysis protocol
Authors: Hoang Quang Vinh , Levecke Bruno , Do Trung Dung , Devleesschauwer Brecht , Lam Binh Vu Thi , Polman Katja , Callens Steven , Dorny Pierre , Dermauw Veronique 
Published: July 2022

Abstract
Background
Fascioliasis is an emerging public health threat in a number of regions worldwide, including Southeast Asia. Up to now, a summary of current knowledge on the occurrence and the distribution in Southeast Asia is lacking. We therefore aim to gather recent information on the distribution and prevalence of and the associated risk factors for Fasciola spp. infections in humans, animals, and plant carriers in Southeast Asia.

Methods
Bibliographic and gray literature databases as well as reference lists of important review articles will be searched for relevant records that are published between January 1, 2000, and the search date. The systematic review will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for reporting systematic reviews. The primary outcomes will be both the prevalence of Fasciola spp. in the human and animal hosts, and on plant carriers in Southeast Asia, and the risk factors for occurrence of Fasciola spp. Secondary outcomes are the prevalence of Fasciola spp. in subpopulations (e.g., children and patients visiting clinics), the mapping of different diagnostic tests used, and the occurrence of the different Fasciola spp. in the study region. A descriptive statistical analysis will be conducted, and a meta-analysis will be run to estimate the prevalence of human and animal fascioliasis respectively, in Southeast Asia.

Discussion
This systematic review will summarize the current knowledge on the epidemiology of Fasciola spp. infections in Southeast Asia.

Systematic review registration
This systematic review has been registered with the International Prospective Register of Systematic Reviews (PROSPERO), reference number: CRD42021261104.
Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy
Authors: Molotsky Elana , Liu Yuhong , Lieberman Andrew P. , Merry Diane E. 
Published: July 2022

AbstractSpinal and bulbar muscular atrophy (SBMA) is an X-linked, neuromuscular neurodegenerative disease for which there is no cure. The disease is characterized by a selective decrease in fast-muscle power (e.g., tongue pressure, grip strength) accompanied by a selective loss of fast-twitch muscle fibers. However, the relationship between neuromuscular junction (NMJ) pathology and fast-twitch motor unit vulnerability has yet to be explored. In this study, we used a cross-model comparison of two mouse models of SBMA to evaluate neuromuscular junction pathology, glycolytic-to-oxidative fiber-type switching, and cytoskeletal alterations in pre- and postsynaptic termini of tibialis anterior (TA), gastrocnemius, and soleus hindlimb muscles. We observed significantly increased NMJ and myofiber pathology in fast-twitch, glycolytic motor units of the TA and gastrocnemius compared to slow-twitch, oxidative motor units of the soleus, as seen by decreased pre- and post-synaptic membrane area, decreased pre- and post-synaptic membrane colocalization, increased acetylcholine receptor compactness, a decrease in endplate area and complexity, and deficits in neurofilament heavy chain. Our data also show evidence for metabolic dysregulation and myofiber atrophy that correlate with severity of NMJ pathology. We propose a model in which the dynamic communicative relationship between the motor neuron and muscle, along with the developmental subtype of the muscle, promotes motor unit subtype specific vulnerability, metabolic alterations, and NMJ pathology.
Textile-type triboelectric nanogenerator using Teflon wrapping wires as wearable power source
Authors: Kim Seonghyeon , Cho Woosung , Won Dong-Joon , Kim Joonwon 
Published: July 2022

AbstractWearable electronic devices such as mobile communication devices, portable computers, and various sensors are the latest significant innovations in technology which use the Internet of Things (IoT) to track personal data. Wearable energy harvesters are required to supply electricity to such devices for the convenience of users. In this study, a textile-type triboelectric nanogenerator (T-TENG), produced using commercial electrode fibers, was fabricated to generate electrical energy using external mechanical stimulation. The commercial fiber was an electrode coated with Teflon on a copper wire with a diameter of ~ 320 μm. Using this commercial fiber, a T-TENG was easily fabricated by knitting and weaving. The performance of the T-TENG was analyzed to understand the effect of force and frequency. It was observed that the performance of the T-TENG did not degrade even under harsh conditions and treatment. The textile-type TENG possessed an energy harvesting capability with an output power density of ~ 0.36 W/m2 and could operate electronic devices by charging a capacitor.
Do Leonardo da Vinci’s drawings, room acoustics and radio astronomy have anything in common?
Authors: Kulowski Andrzej 
Published: July 2022

Abstract
After introducing Leonardo da Vinci’s (LdV) predecessors in the field of light propagation research, his drawings on the topic of reflecting light by a spherical mirror are analysed. The discovery of LdV is presented, according to which, at an infinitely distant source of rays, a small fragment of the canopy is enough to generate a focus, while the rest of the mirror forms a caustic for which LdV did not indicate an application. An analytical description of the energy concentration in the focus and on the caustic is given, together with its reference to the geometric representation of the acoustic field in rooms. Based on the general principles of wave motion, symmetry is shown in the description of energy relations in acoustics and electromagnetism. It is explained why in the sound field in existing halls, instead of a whole caustic only its cusp is observed, which is perceived as a point-like sound focus. The size of the mirror aperture, shown graphically by LdV, is determined. How the development of receiving techniques increased the mirror aperture compared to the LdV estimate is also shown. The implementation of these improvements is presented via the example of the Arecibo and FAST radio telescopes.
Actions of N-acetylcysteine, daptomycin, vancomycin, and linezolid on methicillin-resistant Staphylococcus aureus biofilms in the ventriculoperitoneal shunt infections: an experimental study
Authors: Kuruoglu Tuba , Altun Gamze , Kuruoglu Enis , Turan Derya Bayırlı , Önger Mehmet Emin 
Published: July 2022

Abstract
Background
Shunt systems are used to provide cerebrospinal fluid drainage in the treatment of hydrocephalus. Recently, antibiotic-impregnated shunt systems are used to prevent colonization in the ventriculoperitoneal catheters. Methicillin-resistant Staphylococcus aureus (MRSA) is the most common causative microorganism of shunt infections. The aim of the study is to investigate effects of several substances on MRSA biofilms in the ventriculoperitoneal catheters.

Methods
The present study consists of mainly eight groups (each has two subgroups as antibiotic-impregnated and nonantibiotic-impregnated catheters). In addition, each group contains six molds using MRSA strains. In this study, daptomycin (DAPT) (2 mg/ml), vancomycin (VAN) (10 mg/ml), linezolid (LIN) (2 mg/ml), N-acetylcysteine (NAC) (6 mg/ml), and various combinations of these substances were used to evaluate the treatment against MRSA using scanning electron microscope (SEM) images and microbiological enumeration.

Results
The colony count in the antibiotic-impregnated samples significantly decreased compared to nonantibiotic-impregnated samples in the MRSA, MRSA + DAPT, and MRSA + LIN groups (p < 0.01), respectively. Conversely, the colony count in antibiotic-impregnated samples significantly increased compared to nonantibiotic-impregnated samples in NAC + DAPT and NAC + VAN groups (p < 0.01), respectively.

Conclusions
The results showed that the use of antibiotic-impregnated catheters has a significant impact on the prevention of infection whereas the combination of NAC and DAPT showed better antibiofilm and antibacterial effects than other combinations on the prevention and treatment of nonantibiotic-impregnated catheter infections.
Fast 3D transient electromagnetic forward modeling using BEDS-FDTD algorithm and GPU parallelization
Authors: Liu Shangbin , Chen Chengdong , Sun Huaifeng 
Published: July 2022

The time-step sizes of the conventional finite-difference time-domain (FDTD) method are severely restricted by the Courant-Friedrichs-Lewy stability condition. This may result in excessive iterations, high cost and large runtime, and increasing late-stage cumulative errors in 3D transient electromagnetic (TEM) forward modeling. At present, forward modeling speed is a major obstacle in the development of 3D TEM inversion. To address this issue, a new 3D TEM forward modeling algorithm is presented. In the new algorithm, the backward Euler (BE) scheme is used with a view toward relaxing the stability constraint. However, after using the BE approach, a huge sparse matrix needs to be inverted in each iteration. Directly solving such matrices by Gaussian elimination or an iterative method is still time-consuming and requires large amounts of computer memory. To improve computational efficiency, the direct-splitting (DS) strategy is adopted to transform the large sparse matrices into a series of small diagonally dominant tridiagonal matrices, which are easier to solve. Then, the complex-frequency-shifted perfectly matched layer boundary condition is implemented using the bilinear transform method to reduce the size of the model. To further speed up the calculation process, the codes are then programmed to run on graphics processing unit (GPU) devices. Three models are used for calculations, and the results are compared with other numerical methods to verify the accuracy of our algorithm. After that, to demonstrate the BEDS-FDTD algorithm’s ability to model complex earth structures, a model with a very complex shape is used for the calculation via the conformal mesh technique. In addition, the modeling speed is tested using different GPU devices. We find that an NVIDIA Tesla A100 is able to calculate the 50 × 50 × 50 cell model in only 8 s.
Nuclear speckles – a driving force in gene expression
Authors: Faber Gabriel P. , Nadav-Eliyahu Shani , Shav-Tal Yaron 
Published: July 2022

ABSTRACT
Nuclear speckles are dynamic membraneless bodies located in the cell nucleus. They harbor RNAs and proteins, many of which are splicing factors, that together display complex biophysical properties dictating nuclear speckle formation and maintenance. Although these nuclear bodies were discovered decades ago, only recently has in-depth genomic analysis begun to unravel their essential functions in modulation of gene activity. Major advancements in genomic mapping techniques combined with microscopy approaches have enabled insights into the roles nuclear speckles may play in enhancing gene expression, and how gene positioning to specific nuclear landmarks can regulate gene expression and RNA processing. Some studies have drawn a link between nuclear speckles and disease. Certain maladies either involve nuclear speckles directly or dictate the localization and reorganization of many nuclear speckle factors. This is most striking during viral infection, as viruses alter the entire nuclear architecture and highjack host machinery. As discussed in this Review, nuclear speckles represent a fascinating target of study not only to reveal the links between gene positioning, genome subcompartments and gene activity, but also as a potential target for therapeutics.
Behavioral and psychosocial predictors of depression in Bangladeshi medical students: a cross-sectional study
Authors: Karim Md Rizwanul , Ahmed Helal Uddin , Akhter Shahnaz 
Published: July 2022

Background: Depression, stress, and anxiety were found in a large number of medical undergraduate students, indicating a neglected aspect of their psychology that required immediate attention. The goal of this study was to find out the prevalence of depression among medical students, as well as potential psychosocial and behavioral predictors for depression. Methods: This cross-sectional study was conducted from July to November 2021 among 840 randomly selected medical students from four medical colleges using stratified random sampling. Data were collected using a semi-structured, self-administered questionnaire and were analyzed through the SPSS v.23 software. Multiple regression was performed to assess the effect of several behavioral and psychosocial factors on depression. Results: Among the 840 study participants, 55.7% (n= 468) were female and 44.3% (n= 372) were male. According to the data, the prevalence of depression, anxiety, perceived stress among medical students was found to be 28.8%, 65% and 85% respectively. A strong link was found between depression and anxiety, stress, poor sleep quality, poor academic performance, and a negative social and romantic relationship status. Conclusions: A significant number of medical students are depressed. In order to prevent and treat depression, medical students should be screened for depression and its associated factors.