bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Some Properties of Difference Operator with Some Characterizations
Authors: Fathima Dowlath , Ganie Abdul Hamid 
Published: November 2022

Abstract
In this paper, we introduce the generalized spaces of the form ℋ(f, g, Δ
n
m
), where ℋ represents one of the spaces ℓ∞, c or c
0.The köthe duals corresponding to these spaces will be computed and construction of the Schauder bases for ℋ ∈ {c, c
0} will be given. Also, some matrix characterizations concerning these spaces will be computed. Moreover, the characterization of some classes of compact operators on the spaces ℓ∞(f, g, Δ
n
m
)and c
0(f, g, Δ
n
m
)by employing the Hausdorff measure of non-compactness will be determined.
Determination of the Zinc level in Environmental and Biological Samples in Baiji City by Atomic Absorption Spectrophotometer
Authors: Hasan Mohammed Hasan  
Published: November 2022

This study was conducted to measure Zinc levels in environmental and biological samples. The method was tested with three types of samples, including soil, water, and human blood serum. In this method, 50 samples from each soil, water, and human blood serum were used. The water and soil samples were collected from the Baiji oil refinery, while the human blood serum was collected from the patients in the Baiji hospital. The total Zinc concentration in the environmental and biological samples was measured by atomic absorption spectrophotometry (AAS). The results of the Zinc determination were obtained from the samples taken from the soil for each site under examination. The following values showed the mean average concentration for each site, respectively. site 1 (15±3.5), site 2 (11.5±1.1), site 3 (14.5) ±0.5), and site 4 (13.8±3.8) µg/g. Moreover, the Zinc concentration in the water samples was between 3-14.3 µg/ mL. The Zinc concentration in the blood serum samples of the control and the healthy group was 598 ± 32 µg/mL, and in the patient group was 450 ± 16 µg/mL.
Activity of Immunotherapy Regimens on Primary Renal Tumours: A Systematic Review
Authors: Jones James O. , Ince William H. J. , Welsh Sarah J. , Stewart Grant D. 
Published: November 2022

BACKGROUND: Immune checkpoint inhibitors (ICPIs) are widely used in treating metastatic renal cell carcinoma (RCC). Cytoreductive nephrectomy (CN) forms part of multimodality treatment in advanced disease, however there is no prospective evidence for its use in the ICPI era. Trials of neoadjuvant ICPIs in RCC are underway; understanding the anticipated effect of ICPIs on the primary tumour may help clinical decision making in both localised and advanced settings. METHODS: A systematic search (PubMed, Web of Science, clinicaltrials.gov) of English literature from 2012 to 2022 was performed according to PRISMA guidelines. 2,398 records were identified, 54 were included in the analysis. RESULTS: In the metastatic setting, response in the primary tumour (≥30% reduction in size) is seen in 33–56% of patients treated with dual ICPI or ICPI + VEGFR-TKI. Pathological complete response rates were 14% for patients undergoing CN after a period of ICPI therapy. In the neoadjuvant setting there is a single published trial of VEGFR-TKI + ICPI, 30% of patients had a≥30% reduction in size of the primary. This appears superior to single agent ICPI. Grade 3 adverse event rates are comparable to the metastatic setting. CONCLUSIONS: A period of ICPI combination therapy followed by nephrectomy may be considered for selected patients as a strategy to manage metastatic disease. In the neoadjuvant setting, it is not clear whether ICPI + VEGFR-TKI is superior to VEGFR-TKI alone. There is minimal data on whether either CN after ICPI in metastatic patients, or neoadjuvant ICPI therapy for localised disease, improves long term survival.
Smart Strawberry Advisory System for Mobile Devices
Authors: Fraisse Clyde W. , Peres Natalia A. , Debastiani Andreis José Henrique 
Published: November 2022

Like the web-based SAS, the SAS: Strawberry Advisory System mobile app monitors real-time and forecast weather conditions that increase the risk for Botrytis (gray mold) and anthracnose fruit rots, providing risk level information for each disease. The app provides easy access to the information growers need to make spraying decisions in the field, saving them time, helping improve disease control, and avoiding unnecessary fungicide applications. This 3-page fact sheet provides an overview of the SAS mobile app. Written by Clyde W. Fraisse, Natalia Peres, and José Henrique Andreis, and published by the UF Department of Agricultural and Biological Engineering, August 2015.
AE516/AE516: Smart Strawberry Advisory System for Mobile Devices (ufl.edu)
Carp Edema Virus Disease (CEVD) / Koi Sleepy Disease (KSD)
Authors: Hesami Shohreh , Viadanna Pedro , Steckler Natalie K. , Spears Staci , Thompson Patrick M. , Kelley Karen L. , Yanong Roy P. E. , Francis-Floyd Ruth , Shelley Johnny , Groff Joseph M. , Goodwin Andy , Haenen Olga L. M. , Waltzek Thomas B. 
Published: November 2022

Carp edema virus disease is killing wild and cultured varieties of carp and worrying koi enthusiasts and carp aquaculturists in the United States and around the world. The disease causes skin lesions and swelling and is sometimes called “koi sleepy disease” because infected fish become lethargic and unresponsive. This 6-page fact sheet describes symptoms, diagnosis, prevention, and what fish producers, wholesalers, or retailers can do if they suspect carp may have contracted the disease. Written by Shohreh Hesami, Pedro Viadanna, Natalie Steckler, Staci Spears, Patrick Thompson, Karen Kelley, Roy Yanong, Ruth Francis-Floyd, Johnny Shelley, Joseph Groff, Andy Goodwin, Olga Haenen, and Thomas Waltzek, and published by the School of Forest Resources and Conservation Program in Fisheries and Aquatic Sciences, October 2015.
FA189/FA189: Carp Edema Virus Disease (CEVD) / Koi Sleepy Disease (KSD) (ufl.edu)
The Effects of Regulation on Ornamental Aquaculture Farms in Florida
Authors: Boldt Noah C. , Van Senten Jonathan , Engle Carole R. , Cassiano Eric J. , DiMaggio Matthew A. 
Published: November 2022

Florida’s diverse ornamental aquaculture industry has many unique challenges that set it apart from other aquaculture commodity groups. The numerous production techniques, diversity of species, and various market outlets make the ornamental aquaculture industry an intriguing study in how regulations impact the industry. By understanding those regulatory impacts, we can streamline efforts to address them. A study was conducted to measure the regulatory impact on ornamental aquaculture farms in Florida using on-farm data from 2018. All farms were censused in the state and results covered 82% of the industry with a response rate of 41% of farms. This factsheet discusses the results of that study and the regulatory burden that the ornamental aquaculture industry in Florida endures.
Social Organization of Honey Bees
Authors: Mortensen Ashley N. , Smith Bryan , Ellis James D. 
Published: November 2022

A honey bee colony is a superorganism, which means that together its members function like a single animal. Bees within a colony work together like the cells in a human body. They warm the colony in the winter by vibrating their wings to generate heat and cool it in the summer by ferrying in droplets of water and fanning air over them. Worker bees fan air into and out of the colony entrance in distinct inhalations and exhalations. Colonies reproduce by swarming to create new daughter colonies that in turn thermoregulate, breathe, and reproduce just as a single autonomous animal does. In three pages this fact sheet explains the intricate caste system and age-based division of labor that allows colonies of humankind’s best-loved pollinators to function and thrive. Written by Ashley N. Mortensen, Bryan Smith, and James D. Ellis, and published by the Entomology and Nematology Department, November 2015.
ENY-166/IN1102: The Social Organization of Honey Bees (ufl.edu)
Mutual Synchronization of Antiferromagnetic Spintronic Oscillators
Authors: Mitrofanova A. Yu. , Safin A. R. , Kravchenko O. V. , Nikitov S. A. 
Published: November 2022

Introduction. Recent studies into the properties of spintronic oscillators have led to broadening their scope of practical application as devices for generating and processing signals. The practical implementation of spintronic oscillators is, however, significantly limited by their low power capacity, thus requiring synchronization between devices.Aim. Determination of conditions for the implementation of the synchronous regime of two antiferromagnetic spintronic oscillators coupled by a common current.Materials and methods. To simplify the numerical simulation of a system of coupled resistively antiferromagnetic oscillators, the method of multiple-time-scale analysis was used. This allowed a system of Kuramoto equations to be considered instead of the original system. To determine the locking band of the Kuramoto model, the homoclinic trajectory approximation method was applied.Results. A system of Kuramoto equation for the phases of partial oscillators under the influence of the inertial term and phase shift was obtained. Expressions describing the locking and synchronization band as functions of the system parameters (bias currents and sizes) were derived. The numerically simulated Kuramoto model was used to determine the bands of the synchronous and asynchronous regimes.Conclusion. The results of numerical simulations of the system of Kuramoto equations and the Adler equation for two coupled spintronic oscillators agree well with the theoretically calculated values of locking and synchronization ranges. The scheme for reducing the model of antiferromagnetic oscillators to a Kuramoto model can be further extended to the case of a larger number of coupled oscillators, which will simplify computational experiments and significantly reduce the time required for numerical simulations.
Buruli-RifDACC: Evaluation of the efficacy and cost-effectiveness of high-dose versus standard-dose rifampicin on outcomes in Mycobacterium ulcerans disease, a protocol for a randomised controlled trial in Ghana
Authors: Amoako Yaw Ampem , Agbanyo Abigail , Novignon Jacob , Owusu Lucy , Tuffour Joseph , Asante-Poku Adwoa , Hailemichael Yohannes , Mosweu Iris , Canter Ruth , Opondo Charles , Allen Elizabeth , Pitt Catherine , Yeboah-Manu Dorothy , Walker Stephen L. , Marks Michael , Phillips Richard Odame ,   SHARP collaboration
Published: November 2022

Background: Buruli ulcer (BU) can lead to disfiguring ulcers and permanent disability. The 2030 World Health Organization (WHO) road map for Neglected Tropical Diseases (NTDs) calls for major scaling up in diagnosis and management to eliminate disability due to the disease. Current treatment for BU is with daily oral rifampicin (10mg/kg dose) and clarithromycin (15mg/kg dose) for eight weeks, combined with standard gauze wound dressings. Dialkylcarbamoyl chloride (DACC)-coated dressings have been shown to irreversibly bind bacteria on wound surfaces resulting in their removal when dressings are changed. This trial aims to determine whether combining a high-dose oral rifampicin regimen with DACC dressings can improve the rate of wound healing relative to standard-dose oral rifampicin combined with DACC dressings. Methods: This is an individual, multi-centre Phase 3 randomised controlled trial, which will be conducted in three clinical sites in Ghana. The primary outcome measure will be the mean time to clearance of viable mycobacteria. Cost and health-related quality of life data will be collected, and a cost-effectiveness analysis will be performed. Discussion: The findings from this trial could lead to a change in how BU is treated. A shorter but more efficacious regimen would lead to improved treatment outcomes and potentially substantial financial and economic savings. Trial registration Pan African Clinical Trials Repository (registration number; PACTR202011867644311). Registered on 30th November 2020.
Evaluasi Kepuasan Pengguna Sistem Informasi Akademik Menggunakan Webqual 4.0 Dan Importance-Performance Analysis
Authors: Santoso Herdiesel , Widodo Wahyu 
Published: November 2022

Penerapan sistem informasi akademik tidak selalu berjalan dengan baik. Evaluasi terhadapat kepuasan pengguna sistem mutlak dilakukan. Tujuan penelitian ini adalah untuk mengetahui kepuasan pengguna website Sistem Informasi Akademik (SIAKAD) STMIK El Rahma, dilihat dari kualitas layanan yang dirasakan dengan tingkat harapan. Metode yang digunakan adalah kombinasi antara WebQual 4.0 dan Importance Performance Analysis (IPA). Langkah penelitian dimulai dari studi literatur tentang metode yang digunakan, kemudian dilanjutkan dengan pengumpulan data menggunakan kuesioner yang berasal dari instrumen WebQual. Untuk melihat kuesioner tersebut sudah layak atau belum digunakan untuk mengambil data, dilakukan pengujian validitas dan reliabiltas terhadap pertanyaan dalam kuesioner. Analisis data dilakukan untuk melihat kesenjangan atau gap, dan penyusunan mariks IPA. Hasil penelitian menunjukan bahwa indikator - indikator WebQual untuk kepuasan pengguna layanan SIAKAD, terdistibusi pada kuadran II dan kuadran III matriks IPA. Sedangkan berdasarkan analisis kesenjangan (GAP) kepuasan pengguna untuk dimensi usabilitas, kualitas informasi serta interaksi dan kualitas layanan menunjukan belum dapat memenuhi harapan dari pengguna.

Kata kunci: importance-performance analysis, user satisfaction , WebQual 4.0
Development of the Composition and Technology for Production a Solid Dispersion System by Hot Melt Extrusion to Increase the Bioavailability of the Active Substance
Authors: Gusev K. A. , Maimistov D. N. , Pavlovsky V. I. , Aliev A. R. , Pavlovsky A. V. , Ivanova O. V. , Tsyrenov D. O. , Flisyuk E. V. 
Published: November 2022

Introduction. The solubility of an active pharmaceutical ingredient plays a major role in drug absorption. Hot melt extrusion is a batch or continuous process that allows creating solid dispersion systems based on various carriers in order to increase solubility and bioavailability of active substances. Development of effective and safe analgesics is one of the most vital tasks of organic and medicinal chemistry. An innovative non-opioid analgesic with very low toxicity and low dosage, but practically insoluble in water, was used in this work. It was suggested to obtain a solid dispersion by hot melt extrusion in order to increase bioavailability.Aim. Development a hot melt extrusion technology for production of a solid dispersion system of PAV-0056 as an active substance and Plasdone™ S-630 as a polymeric carrier to increase the solubility.Materials and methods. PAV-0056 (methyl-2-(7-nitro-2-oxo-5-phenyl-3-propoxy-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetate) (JSC "Organica", Russia) Figure 1; Plasdone™ S-630 (Boai NKY Pharmaceuticals Ltd., China); PEG-1500 (Clariant, Switzerland); acetonitrile for chromatography (Thermo Fisher Scientific, Germany). Extrudates were obtained using a HAAKE™ MiniCTW co-rotating twin-screw laboratory extruder (Thermo Fisher Scientific, Germany). Extrudates were examined by optical microscopy and differential scanning calorimetry, and time of water solution stability was determined. The quantitative content of the active substance and related impurities in the 2.5 % solid dispersion of PAV-0056 was determined by HPLC-UV.Results and discussion. Hot melt extrusion process conditions were established for a mixture of 2.5 % PAV-0056 and Plasdone™ S-630. Stability of the extrudate solution in water was studied, the content of the active substance and impurities in the extrudates was determined. Based on the binary mixture, a composition containing 10 % of PEG-1500 was developed. The optimal conditions for the extrusion process were chosen for obtaining a solid dispersion system that meets the requirements of the regulatory documentation for the content of the active substance and impurities.Conclusion. The binary mixture proved to be unsuccessful for the creation of SDS by hot melt extrusion due to significant accumulation of impurities during the extrusion process. By adding PEG-1500 to the composition, it was possible to considerably lower the operating temperature of the process, reduce the impurity content in the extrudate, and maintain satisfactory stability of the PAV-0056 solution in water.
Development of a Preparative Method for Obtaining an Enantiomerically Pure Substance of Salbutamol by Supercritical Fluid Chromatography
Authors: Tsarev V. N. , Bazarnova N. G. , Mikushina I. V. 
Published: November 2022

Introduction. An increasing number of studies conducted in various countries in the field of biopharmacy convincingly show the differences in the physiological effects on the human body of stereoisomers of pharmaceutical substances. As a rule, one of the enantiomers has the necessary pharmacological effect, the other enantiomer is either inert or has a negative side effect. Currently, it is important to obtain enantiomerically pure pharmacological substances from their racemic mixtures.Aim. Obtaining the R-isomer of salbutamol from a racemic mixture of salbutamol and developing a preparative procedure for chiral separation by supercritical fluid chromatography (SFC) with a yield of the target product sufficient for the production process.Materials and Methods. Supercritical fluid chromatography (SFC) is widely used for analytical and preparative separations of enantiomers of pharmaceutical substances. The relevance of the use of supercritical fluid chromatography SFC is largely due to the fact that it uses sub- or supercritical carbon dioxide (SC-CO2) as the main component of the mobile phase (MP). Studies were carried out on semi-preparative Investigator SFC (Waters Corporation, USA) and preparative Prep 200 qSFC (Waters Corporation, USA) supercritical fluid chromatographs with PDA detectors. Samples were weighed to the nearest 0.0001 g on a XPE206DR balance (Mettler Toledo, USA).Results and discussion. The process of chiral separation of salbutamol sulfate by the SFC method on Prep 200 qSFC (Waters Corporation, USA) was studied. It was revealed that in the chromatographic system under supercritical conditions, the salt is separated into acidic and basic residues, which significantly reduces productivity and shortens the duration of continuous operation of the chromatograph. Conditions for the preparative chiral separation of the racemic mixture of salbutamol base into R- and S-isomers with high enantioselectivity and productivity have been developed. The resulting R-isomer of salbutamol base can be converted into the pharmaceutical substance in the form of sulfate or other salt without loss of enantiomeric purity, the S-isomer can be subjected to racemization and subsequent use.Conclusion. A preparative method has been developed for the chiral separation of a racemic mixture of salbutamol by supercritical fluid chromatography (SFC) with a yield of the target product (R-isomer) of 5.5 g per shift (8 hours).
Geno- and phenotypic characteristics and clinical outcomes of CACNA1C gene mutation associated Timothy syndrome, “cardiac only” Timothy syndrome and isolated long QT syndrome 8: A systematic review
Authors: Borbás János , Vámos Máté , Hategan Lidia , Hanák Lilla , Farkas Nelli , Szakács Zsolt , Csupor Dezső , Tél Bálint , Kupó Péter , Csányi Beáta , Nagy Viktória , Komócsi András , Habon Tamás , Hegyi Péter , Sepp Róbert 
Published: November 2022

BackgroundMutations in the CACNA1C gene–encoding for the major Ca2+ channel of the heart–may exhibit a variety of clinical manifestations. These include typical or atypical Timothy syndromes (TS) which are associated with multiple organ manifestations, and cardiac involvement in form of malignant arrhythmias, QTc prolongation, or AV block. “Cardiac only” Timothy syndrome (COTS) shows no extracardiac manifestation, whereas some CACNA1C gene mutations are associated with QTc prolongation alone (isolated long QT syndrome 8, LQT8).MethodsA systematic search of the literature reporting cases of CACNA1C gene mutation associated syndromes, including TS, COTS and isolated LQT8 via major databases published from 2004 through 2019 was performed. Detailed patient-level phenotypic and genotypic characteristics, as well as long-term outcome measures were collected and compared between pre-specified patient groups, defined both on phenotype and genotype.ResultsA total of 59 TS, 6 COTS, and 20 isolated LQT8 index cases were identified. Apart of syndactyly or baldness, there were no major differences regarding clinical manifestations or outcome measures between TS subtypes, either defining TS subtypes on the genotype or based on the phenotype. Both subtypes were characterized by an extreme degree of QTc prolongation (median ≥600 ms) which were reflected in high major adverse cardiac event rate. On the other hand, there were marked differences between TS, COTS, and isolated LQT8. Timothy syndrome was characterized by a much earlier disease onset, much more pronounced QTc prolongation and much higher mortality rate than COTS or isolated LQT8. Similar differences were observed comparing CACNA1C exon 8/8A vs. non-exon 8/8A mutation carriers. TS showed a high degree of genetic homogeneity, as the p.Gly406Arg mutation either in exon 8 or exon 8A alone was responsible for 70% of the cases.ConclusionsClinical phenotypes associated with mutations in the CACNA1C gene show important clinical differences. Timothy syndrome is associated with the most severe clinical phenotype and with the highest risk of morbidity and mortality. However, distinguishing TS subtypes, in any form, are not supported by our data.Systematic review registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42020184737].
Confidence and motivation to teach primary physical education: A survey of specialist primary physical education pre-service teachers in Australia
Authors: Spittle Sharna , Spittle Michael , Encel Kim , Itoh Sho 
Published: November 2022

IntroductionThis study explored confidence and motivation to teach physical education of pre-service teachers specialising in primary school physical education.MethodsParticipants were 277 pre-service teachers with a mean age of 21.37 years (SD = 3.09) enrolled in a Bachelor of Education (P-12) who were specialising in primary physical education (P-6). Pre-service teachers completed the Confidence and Motivation to Teach Primary Physical Education Questionnaire (CMTPPEQ), which measures confidence (management and planning and implementation) and intrinsic, extrinsic, and amotivated types of motivation (knowledge, performance, practice, professional expectations, student outcomes, and disengagement) toward teaching primary school physical education.ResultsPre-service teachers reported higher confidence in implementation and higher motivation in practice and performance, with very low disengagement. Pre-service teachers in first-year were significantly less confident in both management and planning and implementation than other year levels (p &lt; 0.05). Pre-service teachers with less training and experience (completed no units in physical education or who had taught less than one hour of physical education on teaching rounds) were significantly less confident in both management and planning and implementation (p &lt; 0.05). Pre-service teachers reported higher intrinsic motivation for practice and extrinsic motivation for performance, with males reporting significantly higher extrinsic motivation in professional expectations than females (p &lt; 0.05).DiscussionThe study has highlighted the confidence of pre-service primary physical education specialist teachers in implementing physical education, but lower confidence in management and planning. A practical implication from the findings is the importance of training and experience in developing confidence and motivation, even for those specialising in physical education.