bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Levels of ARMS2, COL8A1, RAD51B, and VEGF and their Correlations in Age-related Macular Degeneration
Authors: Battu Priya , Sharma Kaushal , Rain Manjari , Singh Ramandeep , Anand Akshay 
Published: July 2022

Background:
Many factors including genetic and environmental are responsible for the
incidence of Age-related Macular Degeneration (AMD). However, its pathogenesis has not been
clearly elucidated yet.

Objective:
This study aimed to estimate the Age-Related Maculopathy Susceptibility 2 (ARMS2),
Collagen type VIII Alpha 1 chain (COL8A1), Rad 51 paralog(RAD51B), and Vascular Endothelial
Growth Factor (VEGF) protein levels in serum of AMD and control participants and to further investigate
their correlation to understand AMD pathogenesis.

Methods:
For this case-control study, 31 healthy control and 57 AMD patients were recruited from
Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
A blood sample was taken and serum was isolated from it. ELISA (enzyme-linked immunosorbent
assay) was used for the estimation of proteins in the serum of patients.

Results:
ARMS2 and COL8A1 levels were significantly elevated in the AMD group than in the
control group. The highest levels of ARMS2, COL8A1, and VEGF proteins were recorded for the
wet AMD sub-group. The study results endorsed significant positive correlation between these following
molecules; ARMS2 and COL8A1 (r = 0.933, p < 0.0001), ARMS2 and RAD51B (r =
0.704, p < 0.0001), ARMS2 and VEGF (r = 0.925, p < 0.0001), COL8A1 and RAD51B (r = 0.736,
p < 0.0001), COL8A1 and VEGF (r = 0.879, p < 0.0001), and RAD51B and VEGF (r = 0.691,
p < 0.0001).

Conclusion:
The ARMS2 and COL8A1 levels were significantly higher and RAD51B was significantly
lower in the AMD group than controls. Also, a significant statistical correlation was detected
between these molecules, indicating that their interaction may be involved in the pathogenesis
of AMD.
Cutaneous Anthrax in a Farmer Man: A Case Report
Authors: Mahmoudi Hassan 
Published: July 2022

Introduction:
Anthrax is an acute infection caused by Bacillus anthracis, an anaerobic, spore-forming, Gram-positive bacterium. Anthrax disease is a common disease among herbivores and humans that is transmitted to humans through direct contact with farm animals that are sick or have died of anthrax.

Case Summary:
A 43-year-old man having livestock as a profession had a cutaneous anthrax infection on the dorsal surface of his left thumb. The patient was infected with anthrax by slaughtering a sheep infected with Bacillus anthracis. He was treated with penicillin after an early diagnosis of anthrax bacillus.

Conclusion:
Anthrax infection is a highly contagious disease, and early detection is very important. There is a need to strengthen the health care system for farm animals and educate farmers on how not to consume the meat of diseased carcasses and how to dispose them of hygienically, especially in high-risk areas.
An Urban Population Health Observatory for Disease Causal Pathway Analysis and Decision Support: Underlying Explainable Artificial Intelligence Model
Authors: Brakefield Whitney S , Ammar Nariman , Shaban-Nejad Arash 
Published: July 2022

Background
Many researchers have aimed to develop chronic health surveillance systems to assist in public health decision-making. Several digital health solutions created lack the ability to explain their decisions and actions to human users.

Objective
This study sought to (1) expand our existing Urban Population Health Observatory (UPHO) system by incorporating a semantics layer; (2) cohesively employ machine learning and semantic/logical inference to provide measurable evidence and detect pathways leading to undesirable health outcomes; (3) provide clinical use case scenarios and design case studies to identify socioenvironmental determinants of health associated with the prevalence of obesity, and (4) design a dashboard that demonstrates the use of UPHO in the context of obesity surveillance using the provided scenarios.

Methods
The system design includes a knowledge graph generation component that provides contextual knowledge from relevant domains of interest. This system leverages semantics using concepts, properties, and axioms from existing ontologies. In addition, we used the publicly available US Centers for Disease Control and Prevention 500 Cities data set to perform multivariate analysis. A cohesive approach that employs machine learning and semantic/logical inference reveals pathways leading to diseases.

Results
In this study, we present 2 clinical case scenarios and a proof-of-concept prototype design of a dashboard that provides warnings, recommendations, and explanations and demonstrates the use of UPHO in the context of obesity surveillance, treatment, and prevention. While exploring the case scenarios using a support vector regression machine learning model, we found that poverty, lack of physical activity, education, and unemployment were the most important predictive variables that contribute to obesity in Memphis, TN.

Conclusions
The application of UPHO could help reduce health disparities and improve urban population health. The expanded UPHO feature incorporates an additional level of interpretable knowledge to enhance physicians, researchers, and health officials' informed decision-making at both patient and community levels.

International Registered Report Identifier (IRRID)
RR2-10.2196/28269
Effects of Structured Supervised Exercise Training or Motivational Counseling on Pregnant Women’s Physical Activity Level: FitMum - Randomized Controlled Trial
Authors: Knudsen Signe de Place , Alomairah Saud Abdulaziz , Roland Caroline Borup , Jessen Anne Dsane , Hergel Ida-Marie , Clausen Tine D , Larsen Jakob Eg , van Hall Gerrit , Jensen Andreas Kryger , Molsted Stig , Bendix Jane M , Løkkegaard Ellen , Stallknecht Bente 
Published: July 2022

Background
Physical activity (PA) during pregnancy is an effective and safe way to improve maternal health in uncomplicated pregnancies. However, compliance with PA recommendations remains low among pregnant women.

Objective
The purpose of this study was to evaluate the effects of offering structured supervised exercise training (EXE) or motivational counseling on PA (MOT) during pregnancy on moderate-to-vigorous intensity physical activity (MVPA) level. Additionally, complementary measures of PA using the Pregnancy Physical Activity Questionnaire (PPAQ) and gold standard doubly labeled water (DLW) technique were investigated. The hypotheses were that both EXE and MOT would increase MVPA in pregnancy compared with standard care (CON) and that EXE would be more effective than MOT. In addition, the association between MVPA and the number of sessions attended was explored.

Methods
A randomized controlled trial included 220 healthy, inactive pregnant women with a median gestational age of 12.9 (IQR 9.4-13.9) weeks. A total of 219 women were randomized to CON (45/219), EXE (87/219), or MOT (87/219). The primary outcome was MVPA (minutes per week) from randomization to the 29th gestational week obtained by a wrist-worn commercial activity tracker (Vivosport, Garmin International). PA was measured by the activity tracker throughout pregnancy, PPAQ, and DLW. The primary outcome analysis was performed as an analysis of covariance model adjusting for baseline PA.

Results
The average MVPA (minutes per week) from randomization to the 29th gestational week was 33 (95% CI 18 to 47) in CON, 50 (95% CI 39 to 60) in EXE, and 40 (95% CI 30 to 51) in MOT. When adjusted for baseline MVPA, participants in EXE performed 20 (95% CI 4 to 36) minutes per week more MVPA than participants in CON (P=.02). MOT was not more effective than CON; EXE and MOT also did not differ. MVPA was positively associated with the number of exercise sessions attended in EXE from randomization to delivery (P=.04). Attendance was higher for online (due to COVID-19 restrictions) compared with physical exercise training (P=.03). Adverse events and serious adverse events did not differ between groups.

Conclusions
Offering EXE was more effective than CON to increase MVPA among pregnant women, whereas offering MOT was not. MVPA in the intervention groups did not reach the recommended level in pregnancy. Changing the intervention to online due to COVID-19 restrictions did not affect MVPA level but increased exercise participation.

Trial Registration
ClinicalTrials.gov NCT03679130; https://clinicaltrials.gov/ct2/show/NCT03679130

International Registered Report Identifier (IRRID)
RR2-10.1136/bmjopen-2020-043671
Tanduk Alit Vol. 5 (1) 2022
Authors: Editorial Tim 
Published: July 2022

Kilas Kegiatan PKM

Aman Beribadah di Bulan Zulhijah: Urgensi Ibadah Kurban dan Tata Cara Pelaksanaannya di Masa Pandemi
Pendampingan Japanese Language Proficiency Test (JLPT) N5 Bidang Tatabahasa kepada Siswa SMAN 2 dan MAN 1 Lamongan
Pendampingan Penulisan Artikel tentang Peran Guru dalam Pendidikan pada Masa Pandemi
Pendampingan Penerapan Protokol Kesehatan di Kampung Homestay Borobudur
Optimisasi Penjadwalan Pembangkit pada Microgrid dengan Mempertimbangkan Respons Beban
Authors: Nugraha Candra Febri , Subekti Lukman 
Published: July 2022

Abstract – In a smart grid, the adequacy of electricity supply is not only determined by generation, but the electrical demand can also be involved. Demand response is one way to maintain a balance between electricity supply and load by reducing electricity consumption at a certain period. In this study, a microgrid system operating design is proposed by considering the penetration of new and renewable energy and demand response. Optimization is carried out with the aim of obtaining the lowest generation costs, while maximizing customer benefits from the demand response program. The mixed-integer linear programming method is used to determine generator generation and customer load reduction throughout the planning period. The obtained diesel generator operating cost is $116.40 and the total customer load response benefit is $100. Based on the analysis, the demand response is able to help the system maintain a power balance in critical conditions, namely when the supply from the generator is not sufficient. From the test system used, it was found that the load curtailment throughout the planning period is 67.04 kWh for three customers. The distribution of the reduced demand depends on the value of the demand response incentive for each customer. The amount of load reduction is strongly influenced by the specified demand response budget.Keywords – optimal dispatch, demand response, microgrid, mixed-integer linear programmingIntisari – Dalam smart grid, kecukupan pasokan listrik tidak hanya ditentukan oleh pembangkitan saja, tetapi beban listrik juga dapat dilibatkan. Respons beban merupakan salah satu cara untuk menjaga keseimbangan antara pasokan dan beban listrik dengan cara mengurangi pemakaian listrik pada waktu-waktu tertentu. Dalam studi ini diusulkan sebuah desain operasi sistem microgrid dengan mempertimbangkan penetrasi energi baru dan terbarukan serta respons beban. Optimisasi dilakukan dengan tujuan untuk memperoleh biaya pembangkitan terendah, sekaligus memaksimalkan keuntungan pelanggan dari program respons beban. Metode mixed-integer linear programming digunakan untuk menentukan pembangkitan pada generator dan pengurangan beban pelanggan sepanjang periode perencanaan. Biaya operasi pembangkit diesel yang diperoleh adalah $116,40 dan keuntungan respons beban yang diperoleh pelanggan sebesar $100. Berdasarkan analisis, respons beban mampu membantu sistem menjaga keseimbangan daya pada kondisi-kondisi kritis, yaitu ketika suplai dari pembangkit sedang tidak mencukupi. Dari sistem pengujian yang digunakan, diperoleh penurunan beban yang terjadi selama periode penjadwalan adalah 67,04 kWh pada tiga pelanggan. Distribusi beban yang dikurangi bergantung pada nilai insentif respons beban pada tiap-tiap pelanggan. Besarnya penurunan beban sangat dipengaruhi oleh anggaran respons beban yang ditetapkan.Kata kunci – penjadwalan pembangkit, respons beban, microgrid, pemrograman mixed-integer linear
During the COVID-19 Pandemic: Online or Offline Learning in Application of the Drill Method for Volleyball Services?
Authors: Arianto Oktavian , Dimyati  
Published: July 2022

The COVID-19 has infected and forced all world leaders, including Indonesian leader, to make very strong defense to resolve the spread of COVID-19. Therefore, a social distancing rule or restriction has emerged in social interaction and one of its impacts on education that given online and offline learning. In a study on student class 2 IPS 4 senior High School Country 1 Imogiri related direct lesson education physical, especially in the service material for volleyball, is still below the minimum completeness criteria. This is reinforced by the data from the pretest results showing that there are still 40% of students who passed in the top serve. This study uses classroom action research (CAR), which consists of 2 cycles to improve students’ abilities in material that does not find the minimum completeness criteria. The method used, namely exercise with online and offline learning models with an assessment focus on student psychomotoric. In group 1, learning completeness achieved reached 45%. However, these results still have not reached the expectation of completeness of 70% of the whole student in one class study. On group 2 level completeness learning, students reach 75% of students able to perform the top serve technique well. In conclusion, using the drill method with the model online learning, online and offline of group 1 until group 2 improvement by cumulative including tall.
Electric drive training kit sebagai produk inovasi media pembelajaran praktikum mahasiswa pendidikan vokasi: Analisis uji praktikalitas
Authors: Yanto Doni Tri Putra , Candra Oriza , Dewi Citra , Hastuti Hastuti , Zaswita Hermi 
Published: July 2022

This study discusses the practicality test analysis of an innovative product of practicum learning media, namely the Electric drive training kit which is used in electric drive practice lesson for vocational education students, Industrial Electrical Engineering study program. This development is carried out because of the unavailability of practicum learning media that are in accordance with the characteristics of the material and oriented to industrial developments which resulted in the learning process being not optimal. The purpose of the study is to reveal the practicality level of using the Electric drive training kit as a practicum learning media by users, namely lecturers and students. The practicality level is analyzed based on data from lecturers' assessments and student assessments after using the product in the learning process through filling out the practicality assessment sheet. The data are analyzed using percentage analysis and interpreted using a practical interpretation table. Practicality assessment sheets with a Likert scale are used as data collection instruments. The results show that based on the responses of lecturers and students, this media was very practical to use as a practicum learning media in the electric drive practice lesson. Thus, it can be concluded that the Electric drive training kit is very practical to use as a learning media to support the implementation of learning to be more optimal.
Mengkonstruksi Spiritual Capital Berbasis Islamic Values Di Dalam Organisasi Bisnis Islam: A Literature Study
Authors: Abd. Muzakkir  
Published: July 2022

Penelitian ini diajukan untuk membangun konsep spiritual capital berbasis Islamic values di dalam organisasi bisnis Islam. hal ini didasari perlunya konsep aset tidak berwujud (intangible asset). selain itu, konstruksi spiritual capital masih banyak dikaji dalam pandangan sekuler. Dalam upaya menemukan model spiritual capital berbasis Islamic values, penelitian ini menempuh jalan studi literatur/ a literature study. Temuan-temuan dari telaah berbagai jurnal-jurnal kemudian dianalisis secara radikal dan hasilnya disajikan secara sistematis dan komprehensif. Hasil penelitian ini mengungkapkan bahwa spiritual capital didasarkan pada ajaran pokok Islam yakni: akidah, syariat dan akhlak. Dalam organisasi bisnis Islam, spiritual capital dikonsturksi dengan menggunakan pendekatan analisis kebajikan yang ada dalam ukhuwah Islamiyah¸ dengan nilai-nilai yakni: niat, taqwa, ihsan, kepercayaan, kejujuran, keadilan, etqan, konsultasi hingga kesabaran. Dalam upaya penamannya kedalam Organisasi bisnis Islam, diperlukan pendekatan tazkiyatun nafs. Implikasi penelitian ini adalah terbentuknya konsep spiritual capital berbasis Islamic values yang merupakan bagian dari company capital di dalam organisasi bisnis Islam.
IMPLEMENTASI PRINSIP HUKUM EKONOMI SYARIAH PADA AKAD QARDH DI BANK MEGA SYARIAH CABANG PALU
Authors: Moh. Afif  , Nasaruddin  , Nadia  
Published: July 2022

Bank Mega Syariah Palu Branch applies the qardh contract to a multi contract financial product that is used in conjunction with the Hawalah contract, and the Ijarah (fee) contract. Qardh loan according to Bank Mega Syariah is a distribution of funds based on the agreement between the borrower and the bank in accordance with sharia principle. This is based on Indonesia law system Fatwa No. 79/DSN-MUI/2011. Qardh multi contract financial products are manifested from the principles of Islamic economic law in leading to world affairs, so that the habit is used as legal considerations. Loan in Islamic economic law is explained through the principle of binding accountability. However, it cannot be denied that in the Covid-19 pandemic period there are often difficulties in the debtor in returning the loan so that legal support system is needed.
Abstrak
Bank Mega Syariah Cabang Palu mengaplikasikan akad qardh ke dalam produk keuangan multi akad yang digunakan bersamaan dengan akad hawalah, dan akad ijarah (ujrah). Pinjaman qardh menurut Bank Mega Syariah merupakan penyaluran dana yang didasarkan atas persetujuan atau kesepakatan antara peminjam dan pihak bank sesuai dengan prinsip wasathiyah. Hal ini didasarkan pada Fatwa DSN-MUI No. 79/DSN-MUI/2011. Produk keuangan qardh multi akad terwujud dari prinsip hukum ekonomi syariah dalam bermuamalah pada urusan dunia, sehingga kebiasaan tersebut dijadikan pertimbangan hukum. Urusan pinjam meminjam dalam hukum ekonomi syariah diterangkan melalui prinsip pertanggungjawaban yang bersifat mengikat. Namun, tak dapat dipungkiri di masa pandemi Covid-19 sering terjadi kesulitan pada debitur dalam mengembalikan pinjamannya sehingga diperlukannya dukungan payung hukum
PENERAPAN MEDIA KONKRET UNTUK MENINGKATKAN HASIL BELAJAR TEMATIK INTEGRATIF PESERTA DIDIK KELAS 2 MINU NGINGAS
Authors: Salsabila Zuha Prisma , Aliya Nafisatul , Susanti Fadillah Mira , Putri Nurleila Rizqi , Indriyanti Putri , Al Wafa Achmad Syaab Arif , Chasanah Uswatun 
Published: July 2022

Abstrak
Penelitian ini bertujuan untuk meningkatkan hasil belajar peserta didik kelas 2 MINU Ngingas Sidoarjo dengan menggunakan media konkret pada pembelajaran tematik integratif. Metode penelitian yang digunakan adalah Penelitian Tindakan Kelas(PTK) yang mencakup dua siklus. Tiap siklus terdiri dari tiga tahap yaitu perencanaan, tindakan, dan observasi, serta refleksi. Pengumpulan data menggunakan teknik tes, observasi, dan wawancara. Hasil observasi menunjukkan permasalahan ketidaktertarikan peserta didik dengan pembelajaran ceramah. Data wawancara memberikan hasil bahwa peserta didik kurang memahami materi yang abstrak. Masalah yang ditemukan adalah tidak adanya penggunakan media nyata, sehingga mempengaruhi pemahaman peserta didik. Tindakan yang dilakukan dengan menggunakan media konkret dalam pembelajaran tematik integratif menunjukkan bahwa penerapan media konkret terhadap pembelajaran tematik integratif dapat meningkatkan hasil belajar peserta didik kelas 2 MINU Ngingas Sidoarjo. Penggunaan media konkret sangat berpengaruh dalam meningkatkan hasil belajar peserta didik dalam pembelajaran tematik integratif di kelas 2 MINU Ngingas Sidoarjo.
KETERAMPILAN BERTANYA DAN MEMBERI PENGUATAN GURU DALAM PEMBELAJARAN DARING DI TINGKAT SD PADA MASA PANDEMI COVID-19
Authors: Ilham Muhammad , Masdin Masdin , Hardiyanti Waode Eti , Desinatalia Ragil 
Published: July 2022

Abstrak
Penelitian ini bertujuan untuk mengkaji implementasi keterampilan bertanya dan memberi penguatan guru pada pembelajaran daring di masa pandemi Covid-19 di SDN 4 Konawe Selatan. Studi ini merupakan penelitian kualitatif. Informan penelitian adalah kepala sekolah, 6 orang guru, dan 2 orang perwakilan siswa. Data dalam penelitian ini dikumpulkan melalui observasi, wawancara, dan dokumentasi. Data penelitian kemudian dianalisis melalui tahap pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Data kemudian diuji keabsahannya dengan menggunakan trianggulasi teknik dan trianggulasi sumber. Hasil penelitian menunjukkan pembelajaran daring yang dilaksanakan di SDN 4 Konawe Selatan menerapkan model pembelajaran asynchronous dan synchronous. Mayoritas guru menggunakan model asynchronous dalam melaksanakan pembelajaran daring melalui whatsapp group. Pembelajaran synchronous melalui platfrom zoom dan google meet hanya diterapkan di kelas V dan VI. Pada dua model pembelajaran daring, penguatan verbal dan nonverbal tetap diberikan guru, tetapi implementasi penguatan tersebut sangat terbatas pada pembelajaran asynchronous.
EFEKTIVITAS PEMBELAJARAN DARING DALAM MENINGKATKAN KECAKAPAN TEKNOLOGI DAN KELEKATAN ORANG TUA DENGAN SISWA SEKOLAH DASAR
Authors: Masluhah Masluhah , Udhmah Syafaatul , Isnaini Nur Fajriyatul , Lailiyah Siti 
Published: July 2022

Abstrak
Pandemi Covid-19 telah mengalihkan sistem pembelajaran tatap muka menjadi pembelajaran dalam jaringan (daring) yang tidak terlepas dari akses teknologi digital dan kelekatan orang tua dengan siswa dalam kegiatan belajar di rumah. Penelitian ini bertujuan untuk mengetahui efektivitas pembelajaran daring terhadap kecakapan teknologi dan kelekatan orang tua dengan siswa sekolah dasar. Metode yang digunakan adalah kuantitatif dengan pendekatan survei. Teknik pengambilan sampel berupa random sampling dengan jumlah populasi 396 orang dan 40 partisipan merupakan orang tua siswa di MI Islamiyah Ngoro Jombang. Teknik pengumpulan data menggunakan kuisioner. Analisis data dilakukan dengan uji statistik deskriptif dan uji manova (multivariate analysis of variance). Hasil penelitian menyatakan sebanyak 13 siswa mengikuti pembelajaran daring (X) kurang dari 1 tahun, dan 27 siswa lebih dari 1 tahun. Pembelajaran daring memiliki pengaruh yang signifikan terhadap kecakapan teknologi dan kelekatan orang tua dengan siswa. Sehingga disimpulkan bahwa pembelajaran daring efektif dalam meningkatkan kecakapan teknologi dan kelekatan orang tua dengan siswa di MI Islamiyah Ngoro Jombang.