bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causes of preterm birth: Genetic factors in preterm birth and preterm infant phenotypes
Authors: Dauengauer‐Kirlienė Svetlana , Domarkienė Ingrida , Pilypienė Ingrida , Žukauskaitė Gabrielė , Kučinskas Vaidutis , Matulevičienė Aušra 
Published: December 2022

AbstractAimThe aim is to provide an overview of recent research on genetic factors that influence preterm birth in the context of neonatal phenotypic assessment.MethodsThis is a nonsystematic review of the recent scientific literature.ResultsMaternal and fetal genetic diversity and rare genome variants are linked with crucial immune response sites. In addition, more frequent in preterm neonates, de novo variants may lead to attention deficits, hyperactivity, autism spectrum disorders, and infertility of both sexes later in life. Environmental factors may also greatly burden fetal, and consequently, neonatal development and neurodevelopment through a failure in the fetal epigenome reprogramming process and even influence the initiation of spontaneous preterm pregnancy termination. Minimally invasive analysis of the transcription factors associated with preterm birth helps elucidate labor mechanisms and predict its timing. We also provide valuable summaries of genomic and transcriptomic factors that contribute to preterm birth.ConclusionsInvestigation of the human genome, epigenome, and transcriptome helps to identify molecular mechanisms linked with preterm delivery and premature newborn clinical appearance in early and late neonatal life and even predict developmental outcomes. Further studies are needed to fully understand the implications of genetic changes in preterm births. These data could be used to develop targeted interventions aimed at selecting the most effective individual treatment and rehabilitation plan.
‘‘Reclaiming our time’’: Black mothers cultivating the homeplace during times of crisis
Authors: Coleman‐King Chonika , Brown Taryrn T. C , Haynes‐Thoby Latoya , Dowie‐Chin Tianna 
Published: December 2022

AbstractThis collaborative auto‐ethnography provides an account of the sociohistorical context of Black mothering in the United States and highlights how our complex, intersectional identities as Black‐(other)mother‐scholars shape our cultivation of the homeplace—a place where Black children are nurtured as “subjects, not objects,” in a society that aims to dominate black bodies. Drawing on Black feminism and Black Woman's Geographies, we document how time at home with our children during COVID‐19 allowed for critical dialogue regarding racial injustice and exposure to culturally sustaining educational content endeavored toward resilience building. This work highlights the strength of Black mothers’ collective experiences in fostering resilience amidst crises. Societal implications of COVID‐19 amidst ongoing racial traumas reify the need to reclaim not only our time as Black mothers, but also our voice, agency, and the spaces we cultivate for Black children's liberation. We also discuss recommendations for amplifying Black mothers’ voices in education policy efforts such that schools are better prepared to serve Black children.
What Does Explicit Knowledge Look Like? An Analysis of Information Structure in Rule Formation by L2 Learners and Its Relationship With Guided Inductive Learning
Authors: MALOVRH PAUL A. , LEE JAMES F. 
Published: December 2022

AbstractResearch examining rule formation and second language (L2) explicit knowledge during guided inductive instruction has focused on co‐constructed metalanguage or depth of processing (DoP) using think‐aloud protocols, but without analyzing rule features. Studies have not focused on the architecture of the rules that L2 learners create individually. The present study provides a research design that elicits rules in purposeful tasks controlled for uniformity across multiple participants (N = 20), establishing a framework to analyze explicit knowledge according to information structure and its relationship with language processing. Qualitative analyses yielded 4 main findings: (a) L2 explicit knowledge is learnable from guided induction, (b) it can be analyzed for information structure, (c) more complete information structure reflects greater DoP, and (d) explicit knowledge varies in its written information structure based on rule completeness, linguistic features included, and the order in which linguistic features are mentioned.
Electrical devices for functional visceral pain
Authors: Camilleri Michael 
Published: December 2022

AbstractSeveral studies have documented correction of dysmotility in several regions of the gastrointestinal tract based on electrical stimulation of extrinsic nerves supplying those regions. In this issue of Neurogastroenterology and Motility, Ma et al. (2023) document the effect of transcutaneous neuromodulation applied by acustimulation at ST36 for ineffective esophageal motility in patients with gastroesophageal reflux disease. In addition to motor effects, there were also significant effects on GERD symptoms, raising the question whether extrinsic electrical nerve stimulation of the gut can reduce symptoms through effects that target sensation. This brief review summarizes evidence regarding the application of electrical acustimulation, transauricular electrical stimulation, and sacral electrical or magnetic stimulation to reduce abdominal or pelvic pain.
Longer epidermal cells underlie a quantitative source of variation in wheat flag leaf size
Authors: Zanella Camila M. , Rotondo Marilena , McCormick‐Barnes Charlie , Mellers Greg , Corsi Beatrice , Berry Simon , Ciccone Giulia , Day Rob , Faralli Michele , Galle Alexander , Gardner Keith A. , Jacobs John , Ober Eric S. , Sánchez del Rio Ana , Van Rie Jeroen , Lawson Tracy , Cockram James 
Published: December 2022

Summary
The wheat flag leaf is the main contributor of photosynthetic assimilates to developing grains. Understanding how canopy architecture strategies affect source strength and yield will aid improved crop design.
We used an eight‐founder population to investigate the genetic architecture of flag leaf area, length, width and angle in European wheat. For the strongest genetic locus identified, we subsequently created a near‐isogenic line (NIL) pair for more detailed investigation across seven test environments.
Genetic control of traits investigated was highly polygenic, with colocalisation of replicated quantitative trait loci (QTL) for one or more traits identifying 24 loci. For QTL QFll.niab‐5A.1 (FLL5A), development of a NIL pair found the FLL5A+ allele commonly conferred a c. 7% increase in flag and second leaf length and a more erect leaf angle, resulting in higher flag and/or second leaf area. Increased FLL5A‐mediated flag leaf length was associated with: (1) longer pavement cells and (2) larger stomata at lower density, with a trend for decreased maximum stomatal conductance (Gsmax) per unit leaf area.
For FLL5A, cell size rather than number predominantly determined leaf length. The observed trade‐offs between leaf size and stomatal morphology highlight the need for future studies to consider these traits at the whole‐leaf level.
Genetics of fertility restoration in A2‐based cytoplasmic genetic male sterility system in pigeonpea (Cajanus cajan)
Authors: Ranjani M. S. , Jayamani P. 
Published: December 2022

AbstractThe three short duration cytoplasmic genetic male sterility (CGMS) hybrids developed using A2 (Cajanus scarabeoides) cytoplasm‐based male sterile lines (CORG 990047A, CORG 990052A and CORG 7A) and the restorer inbred AK 261322 and their segregating populations (F2 and BC1F1) were subjected to the study of inheritance of fertility restoration in pigeonpea. The fertility restoration was studied based on three different criteria, namely, anther colour, pollen grain fertility and pollen grain morphology and staining. The F2 and BC1F1 populations of the three crosses, namely, CORG 990047A × AK 261322, CORG 990052A × AK 261322 and CORG 7A × AK 261322, segregated in the ratio of 3:1 and 1:1, for anther colour (yellow:pale yellow), pollen grain fertility (fertile:sterile) and for pollen grain morphology and staining. The above study confirmed that the trait fertility restoration was controlled by single dominant gene. This finding can be utilized for the identification of potential restorers, which can be further used in the development of CGMS‐based hybrids in pigeonpea.
Linking genetic markers with an eco‐physiological model to pyramid favourable alleles and design wheat ideotypes
Authors: Li Yibo , Tao Fulu , Hao Yuanfeng , Tong Jingyang , Xiao Yonggui , Zhang He , He Zhonghu , Reynolds Matthew 
Published: December 2022

AbstractGenetic markers can be linked with eco‐physiological crop models to accurately predict genotype performance and individual markers' contributions in target environments, exploring interactions between genotype and environment. Here, wheat (Triticum aestivum L.) yield was dissected into seven traits corresponding to cultivar genetic coefficients in an eco‐physiological model. Loci for these traits were discovered through the genome‐wide association studies (GWAS). The cultivar genetic coefficients were derived from the loci using multiple linear regression or random forest, building a marker‐based eco‐physiological model. It is then applied to simulate wheat yields and design virtual ideotypes. The results indicated that the loci identified through GWAS explained 46%–75% variations in cultivar genetic coefficients. Using the marker‐based model, the normalized root mean square error (nRMSE) between the simulated yield and observed yield was 13.95% by multiple linear regression and 13.62% by random forest. The nRMSE between the simulated and observed maturity dates was 1.24% by multiple linear regression and 1.11% by random forest, respectively. Structural equation modelling indicated that variations in grain yield could be well explained by cultivar genetic coefficients and phenological data. In addition, 24 pleiotropic loci in this study were detected on 15 chromosomes. More significant loci were detected by the model‐based dissection method than considering yield per se. Ideotypes were identified by higher yield and more favourable alleles of cultivar genetic traits. This study proposes a genotype‐to‐phenotype approach and demonstrates novel ideas and tools to support the effective breeding of new cultivars with high yield through pyramiding favourable alleles and designing crop ideotypes.
Partnering to prepare: An academic/workforce collaboration to develop disaster shelter training for nurses
Authors: Nouredini Sahar , Holbrook Katherine , Ladua Zerlyn 
Published: December 2022

AbstractIn California, more frequent, intense, and destructive wildfires have prompted public health departments to enhance disaster response plans as evacuations and shelter needs increase. In addition, individuals utilizing shelters have increasingly complex medical and behavioral health needs and are accessing shelters for longer periods of time. Public health nurses (PHNs) are often called to staff disaster shelters but may have less recent experience in, or comfort with, direct patient care. Many health departments are experiencing challenges developing sustainable training infrastructure that prepares PHNs to deliver direct patient care in disaster shelters. Partnering with academic institutions can address this challenge. This article describes a partnership between a regional collaborative of health jurisdictions and a public university to train public health nurses to work in disaster shelters. The training demonstrates a sustainable way to instruct public health nurses while also highlighting the potential of partnerships between academic institutions and local health departments to address disaster preparedness and response needs in a community. Public health nurses are essential to public health preparedness and providing additional training can augment their ability to respond to disasters.
Inhibition of cholesterol transport impairs Cav‐1 trafficking and small extracellular vesicles secretion, promoting amphisome formation in melanoma cells
Authors: Peruzzu Daniela , Boussadia Zaira , Fratini Federica , Spadaro Francesca , Bertuccini Lucia , Sanchez Massimo , Carollo Maria , Matarrese Paola , Falchi Mario , Iosi Francesca , Raggi Carla , Parolini Isabella , Carè Alessandra , Sargiacomo Massimo , Gagliardi Maria Cristina , Fecchi Katia 
Published: December 2022

AbstractCaveolin‐1 (Cav‐1) is a fundamental constituent of caveolae, whose functionality and structure are strictly dependent on cholesterol. In this work the U18666A inhibitor was used to study the role of cholesterol transport in the endosomal degradative‐secretory system in a metastatic human melanoma cell line (WM266‐4). We found that U18666A induces a shift of Cav‐1 from the plasma membrane to the endolysosomal compartment, which is involved, through Multi Vesicular Bodies (MVBs), in the formation and release of small extracellular vesicles (sEVs). Moreover, this inhibitor induces an increase in the production of sEVs with chemical–physical characteristics similar to control sEVs but with a different protein composition (lower expression of Cav‐1 and increase of LC3II) and reduced transfer capacity on target cells. Furthermore, we determined that U18666A affects mitochondrial function and also cancer cell aggressive features, such as migration and invasion. Taken together, these results indicate that the blockage of cholesterol transport, determining the internalization of Cav‐1, may modify sEVs secretory pathways through an increased fusion between autophagosomes and MVBs to form amphisome, which in turn fuses with the plasma membrane releasing a heterogeneous population of sEVs to maintain homeostasis and ensure correct cellular functionality.
Granulocyte concentrate splitting does not affect phenotype and function
Authors: Koo Sebastian , Offner Robert , Haile Sophie‐Marie , Brosig Andreas , Hähnel Viola , Gruber Michael , Burkhardt Ralph , Ahrens Norbert 
Published: December 2022

AbstractBackgroundMore granulocyte concentrates (GCs) could be produced for more patients from the same donor if apheresis bags were split and stored for longer periods of time. Hence, we tested the hypothesis that splitting and extension of storage of GCs do not impair granulocyte function or viability.Study Design and MethodsGranulocyte apheresis concentrates were produced using modified fluid gelatin as a separation enhancer, split into two portions, and stored for 24 and 48 h. Granulocyte function, represented by cell migration, reactive oxygen species (ROS) production, and neutrophil extracellular trap formation (NETosis), was measured by live‐cell imaging. ROS production, adhesive surface protein expression, and viability were measured by flow cytometry.ResultsSplitting had no effect on any of the tested parameters. After 24 h of storage, live‐cell imaging showed no significant difference in migration, time to maximum ROS production, time to half‐maximum NETosis, viability, or CD11b expression, but ROS production induced by phorbol 12‐myristate 13‐acetate (PMA) decreased from an initial median fluorescence intensity of 1775–590 artificial units. After 48 h, PMA‐induced ROS production, viability, and migration declined, as reflected by decreases in median total distance (119 vs. 63.5 μm) and median Euclidean distance (30.75 vs. 14.3 μm).ConclusionSplitting GC products has no effect on granulocyte viability or function, but extended storage >24 h does compromise granulocyte function. The findings confirm that GCs should be transfused within 24 h of collection. Longer storage cannot be recommended.
Oxidative degradation of sulfamethazine in aqueous solution by the activation of Na2S2O8 over vinasse‐derived N,S‐codoped mesoporous carbon
Authors: Xing Bo , Fu Chaoting , Yang Guo , Song Xiang , Liu Xingyong , Liu Xiaonan , Zhou Qiang , Pan Zhongcai , You Junjie , Ye Yuling 
Published: December 2022

AbstractN,S‐codoped mesoporous carbon (S/NMC) as an effective catalyst toward the catalytic persulfate oxidation of sulfamethazine (SMZ) was fabricated conveniently using vinasse as the C/N source, Na2S as the S precursor and nano‐SiO2 as the template, respectively. The effect of S precursor dosage on the textural properties and surface chemistry of S/NMCs were characterized by N2 adsorption/desorption, Raman spectra, X‐ray diffractometer (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT‐IR) and X‐ray photoelectron spectroscopy (XPS). It was found that more S precursor dosage presented an enhanced SMZ degradation performance due to the significant role of more S precursor dosage: (i) larger specific surface area and (ii) more active surface groups including pyridine N, graphite N, quinone‐like O and thiophene‐like S. In addition, quenching experiments showed that free radical and nonradical oxidation processes are the main processes of SMZ degradation. The findings provided a new idea for the resource utilization of vinasse and the development of catalytic persulfate oxidation of organic pollution.
Antibiotic‐loaded bone substitutes therapy in the management of the moderate to severe diabetic foot infection: A meta‐analysis
Authors: Lin Xinyi , Wu Yan , Huang Hong , Peng Ruihan , Huang FuHua , Hong Lvrong , Chen WenZhuan 
Published: December 2022

AbstractIn recent years, local antibiotic‐loaded bone substitutes (ALBS) have been used increasingly in the treatment of diabetic foot infection (DFI). The meta‐analysis aimed to analyse the efficacy of ALBS on patients with moderate to severe DFI (with or without osteomyelitis). With an appropriate search strategy, 7 studies were selected for analysis (2 RCTs and 5 cohort studies). The result showed that the application of ALBS effectively reduced the length of hospital stay (WMD −5.55; 95% CI: −9.85 to −1.26;P = 0.01), the recurrence rates (RR 0.33; 95% CI: 0.15 to 0.69;P = 0.003) and the mortality rates (RR 0.22; 95% CI: 0.06 to 0.82;P = 0.02). Compared to the control groups, however, there was no difference in healing rates (RR 1.06; 95% CI: 0.96 to 1.18;P = 0.26), healing time (WMD −1.44; 95% CI: −3.37 to −0.49;P = 0.14), the number of debridement (WMD −1.98; 95% CI: −4.08 to 0.12;P = 0.06) and major amputation rates (RR 0.76; 95% CI: 0.35 to 1.61;P = 0.47). The ALBS appears to have some beneficial effects as an adjunct to standard surgery in the treatment of DFI with or without osteomyelitis, as it reduces recurrence rates, mortality rates, and length of hospital stay, but there was no statistically significant difference in enhancing wound healing.
Perspectives on Postmatch Fatigue From 300 Elite European Soccer Players
Authors: Di Salvo Valter , Bonanno Daniele , Modonutti Mattia , Scanavino Andrea , Donatelli Claudio , Pigozzi Fabio , Lolli Lorenzo 
Published: December 2022

Purpose: To examine the general perspectives of elite soccer players on the time course of perceived postmatch fatigue and the influence of away matches on subjective perceptions. Methods: Adopting a cross-sectional study design, we invited 371 subjects from 14 top-division European clubs competing in the Belgian First Division A, English Premier League, French Ligue 1, Italian Serie A, Portuguese Primeira Liga, Russian Premier League, and Swiss Premier League to take part in a short survey on general issues relating to postmatch fatigue measurement and tracking in professional soccer. Results: Three hundred male professional soccer players completed the short questionnaire. For perceptions relevant to the time course of postmatch fatigue, two-thirds of respondents (67%) indicated higher postmatch fatigue perceived 2 days (48 h) after an official competition. Among these respondents, a higher proportion of answers was observed in wide midfielders (74%), attackers (74%), and central midfielders (68%). Approximately two-thirds of respondents (63%) indicated more than usual and much more than usual perceived postmatch fatigue following away matches. Conclusions: For the first time, our investigation addressed practical aspects that remained unexplored and fundamental to the definition of an optimal player management process following a competition. From a practical standpoint, perspectives of individual elite soccer players substantiated the notion of implementing processes with dedicated recovery protocols within 48 hours postmatch and highlighted the need for differential strategies addressing the additional burden of away matches and travel.
A review of cyberinfrastructure for machine learning and big data in the geosciences
Authors: Sun* Ziheng , Cristea Nicoleta , Tong Daniel , Tullis Jason , Chester Zachary , Magill Andrew 
Published: December 2022

ABSTRACT
The use of artificial intelligence (AI) and machine learning (ML) methods in the geosciences can be categorized into three types, those that: (1) accelerate computationally expensive Earth system models; (2) fill the vacuum where numerical and physics-based models struggle; and (3) enable and enlighten data-driven discoveries. To achieve these tasks, many cyberinfrastructure (CI) systems are required. This chapter reviews the cutting-edge CI aiding the implementation of AI in the geosciences. Each technique presented is evaluated to assist geoscientists in determining how appropriate it is. Use cases in the subdomains of seismology, hydrology, and climatology are introduced to help readers understand the workflows. Challenges and future opportunities for CI development center on big data, provenance, interoperability, and heterogeneity due to the scale and complexity that future AI models in the geosciences will require.
Tropospheric Ozone Concentration on the Territory of Russia in 2021
Authors: Andreev V. V. , Arshinov M. Yu. , Belan B. D. , Belan S. B. , Davydov D. K. , Demin V. I. , Dudorova N. V. , Elansky N. F. , Zhamsueva G. S. , Zayakhanov A. S. , Ivlev G. A. , Kozlov A. V. , Konovaltseva L. V. , Kotel’nikov S. N. , Kuznetsova I. N. , Lapchenko V. A. , Lezina E. A. , Obolkin V. A. , Postylyakov O. V. , Potemkin V. L. , Savkin D. E. , Senik I. A. , Stepanov E. V. , Tolmachev G. N. , Fofonov A. V. , Khodzher T. V. , Chelibanov I. V. , Chelibanov V. P. , Shirotov V. V. , Shukurov K. A. 
Published: December 2022

AbstractOzone is one of the most toxic admixtures in the troposphere. Therefore, it is among the main pollutants and its concentration is monitored. This work represents an overview of continuous measurements of the ozone content in the troposphere on the territory of Russia throughout 2021 carried out on an initiative of scientific and educational institutions at 17 stations in different Russian regions. The monitoring results showed that the daily average ozone concentration exceeded the MPCd.alevel during a major part of the year at all observation sites, and by a factor of two or even three at a number of stations. At six stations, concentrations in excess of the maximum permissible one-time concentration MPCm.owere recorded. This requires a more comprehensive analysis of the composition and concentration of ozone precurcors and the development of measures to reduce their emission into the atmosphere.