bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of Aboriginal family wellbeing to social and cultural determinants, Central Australia: ‘Waltja tjutangku nyakunytjaku’
Authors: Wright Alyson , Davis Vanessa Napaltjarri , Brinckley Makayla-May , Lovett Raymond , Thandrayen Joanne , Yap Mandy , Sanders William , Banks Emily 
Published: November 2022

ObjectiveThe objective of this study was to apply a strength-based approach to examine the relation of cultural and social determinants to high family functioning for Aboriginal people in Central Australia.DesignCross-sectional study involving a quantitative analysis of survey data. Prevalence rate ratios (PRs) and 95% CIs were calculated from binomial regressions, adjusted for gender and age. Qualitative data from workshops with Aboriginal leaders in Central Australia supported the interpretation of the research findings.ParticipantsThe study involved 639 Aboriginal people in Central Australia who participated in the Mayi Kuwayu Study.ResultOverall, 57.9% (370/639) of participants reported high/very high family functioning, 16.9% (108/639) reported moderate and 13.3% (85/639) reported low. The adjusted prevalence of family functioning was similar across gender, age groups and household sizes. Family functioning was associated with lower family financial status (aPR=0.74, 95% CI=0.60 to 0.91) and receiving welfare (0.88, 0.77 to 1.00). Family functioning was greater with high community cohesion (2.72, 1.68 to 4.39), high individual agency in community (2.15, 1.63 to 2.85); having an Aboriginal language as a first language (1.20, 1.04 to 1.37); speaking your Aboriginal language a lot (1.37, 1.12 to 1.68); high exposure to cultural practice and knowledge (1.45, 1.28 to 1.65); and multigenerational or extended family households (1.19, 1.02 to 1.38).ConclusionHigh family functioning is a strength in Central Australia and is intrinsically connected with culture. Healthcare providers and programmes that build on the foundations of culture and family are an important approach to improving wellbeing.
Complexation-induced N‒P axial chirality in Sm(II) N-phosphine oxide-substituted imidazolylidene and imidazolinylidene complexes
Authors: Hoshimoto Yoichi , Yamauchi Yasuhiro , Terada Tomoya , Ogoshi Sensuke 
Published: November 2022

Two types of Sm(II) complexes bearing either an N-phosphine oxide-substituted imidazolylidene (PoxIm) or the corresponding imidazolinylidene (SPoxIm) were successfully prepared and characterized using single-crystal X-ray diffraction analysis. The general formula of the structures of the complexes was found to be ( anti-κ-O-(S)PoxIm) nSmX2(THF) m where X = I, n = 2, and m = 2 or X = pentamethylcyclopentadienyl, n = 1, and m = 0. The carbene carbon atoms remained intact in these complexes. In some cases, axial chirality was clearly induced around the N‒P bonds due to the restricted rotation of the N-phosphinoyl moieties, which arises from the formation of N-phosphinoyl oxygen‒Sm(II) bonds. This work highlights a rare example of complexation-induced N‒P axial chirality and new aspects regarding lanthanide complexes of multifunctional multipurpose carbenes.
Identification of Malassezia globosa as a Gastric Fungus Associated with PD-L1 Expression and Overall Survival of Patients with Gastric Cancer
Authors: Zhang Zhenzhan , Qiu Yaopeng , Feng Hao , Huang Donghua , Weng Binshu , Xu Zhou , Xie Qingfeng , Wang Zhe , Ding Wenfu , Li Guoxin , Liu Hao 
Published: November 2022

Background. Microbiotas affected the prognosis of cancer patients by regulating programmed death ligand-1 (PD-L1) expression. However, the relationship between gastric fungi and PD-L1 expression is still unclear in gastric cancer (GC). We aimed at exploring the association of gastric fungi with PD-L1 expression and overall survival in GC. Methods. A total of 61 GC patients were divided into the two groups based on the PD-L1 combined positive scores (CPS). Fungal profiling was performed by internal transcribed spacer rDNA sequencing, and the survival analyses were performed by Kaplan-Meier curves. Results. We observed a taxonomic difference of fungi between the PD-L1-High (

C
P
S
≥
10

) and PD-L1-Low group (

C
P
S
<
10

) by principal coordinates analysis (PCoA) (

P
=
0.014

for Bray-Curtis and

P
=
0.042

for Jaccard). Malassezia had a higher abundance in the PD-L1-High group compared to the PD-L1-Low group (

P
=
0.045

). Malassezia globosa elevated significantly in the PD-L1-High group. GC patients with PD-L1 low expression and low abundance of Malassezia globosa had a longer overall survival (OS) than others (

P
=
0.047

). Malassezia globosa was associated with PD-L1 expression (

O
d
d
s

R
a
t
i
o
=
3.509

, 95% Confidence Interval: 1.056-11.656,

P
=
0.040

). Malassezia globosa was associated with the tumor size (

P
=
0.031

) and PD-L1 status (

P
=
0.024

). GC patients with a high abundance of Malassezia globosa had shorter OS than others (

P
=
0.028

). Malassezia globosa was an independent factor (

H
a
z
a
r
d

R
a
t
i
o
=
3.080

, 95% Confidence Interval: 1.140-8.323,

P
=
0.027

) for OS after adjusting for tumor stage. Malassezia globosa was figured out to be associated with- fatty acid and lipid biosynthesis and degradation via LIPASYN pathway. Conclusions. Malassezia globosa was identified as a PD-L1 expression-associated gastric fungus and associated with OS of GC patients, which calls for more studies to further explore its potential in PD-L1/PD-1 targeted immunotherapy.
Apolipoprotein A1 Protects Against Necrotic Core Development in Atherosclerotic Plaques: PDZK1-Dependent High-Density Lipoprotein Suppression of Necroptosis in Macrophages
Authors: Kluck George E.G. , Qian Alexander S. , Sakarya Emmanuel H. , Quach Henry , Deng Yak D. , Trigatti Bernardo L. 
Published: November 2022

Background:
Atherosclerosis is a chronic disease affecting artery wall and a major contributor to cardiovascular diseases. Large necrotic cores increase risk of plaque rupture leading to thrombus formation. Necrotic cores are rich in debris from dead macrophages. Programmed necrosis (necroptosis) contributes to necrotic core formation. HDL (high-density lipoprotein) exerts direct atheroprotective effects on different cells within atherosclerotic plaques. Some of these depend on the SR-B1 (scavenger receptor class B type I) and the adapter protein PDZK1 (postsynaptic density protein/Drosophila disc-large protein/Zonula occludens protein containing 1). However, a role for HDL in protecting against necroptosis and necrotic core formation in atherosclerosis is not completely understood.

Methods:
Low-density lipoprotein receptor–deficient mice engineered to express different amounts of ApoA1 (apolipoprotein A1), or to lack PDZK1 were fed a high fat diet for 10 weeks. Atherosclerotic plaque areas, necrotic cores, and key necroptosis mediators, RIPK3 (receptor interacting protein kinase 3), and MLKL (mixed lineage kinase domain-like protein) were characterized. Cultured macrophages were treated with HDL to determine its effects, as well as the roles of SR-B1, PDZK1, and the PI3K (phosphoinositide 3-kinase) signaling pathway on necroptotic cell death.

Results:

Genetic overexpression reduced, and ApoA1 knockout increased necrotic core formation and RIPK3 and MLKL within atherosclerotic plaques. Macrophages were protected against necroptosis by HDL and this protection required SR-B1, PDZK1, and PI3K/Akt pathway. PDZK1 knockout increased atherosclerosis in LDLR
KO
mice, increasing necrotic cores and phospho-MLKL; both of which were reversed by restoring PDZK1 in BM-derived cells.

Conclusions:
Our findings demonstrate that HDL in vitro and ApoA1, in vivo, protect against necroptosis in macrophages and necrotic core formation in atherosclerosis, suggesting a pathway that could be a target for the treatment of atherosclerosis.
Contrasting Ocean–Atmosphere Dynamics Mediate Flood Hazard across the Mississippi River Basin
Authors: Muñoz Samuel E. , Hamilton Brynnydd , Parazin B. 
Published: November 2022

Abstract
The Mississippi River basin drains nearly one-half of the contiguous United States, and its rivers serve as economic corridors that facilitate trade and transportation. Flooding remains a perennial hazard on the major tributaries of the Mississippi River basin, and reducing the economic and humanitarian consequences of these events depends on improving their seasonal predictability. Here, we use climate reanalysis and river gauge data to document the evolution of floods on the Missouri and Ohio Rivers—the two largest tributaries of the Mississippi River—and how they are influenced by major modes of climate variability centered in the Pacific and Atlantic Oceans. We show that the largest floods on these tributaries are preceded by the advection and convergence of moisture from the Gulf of Mexico following distinct atmospheric mechanisms, where Missouri River floods are associated with heavy spring and summer precipitation events delivered by the Great Plains low-level jet, whereas Ohio River floods are associated with frontal precipitation events in winter when the North Atlantic subtropical high is anomalously strong. Further, we demonstrate that the El Niño–Southern Oscillation can serve as a precursor for floods on these rivers by mediating antecedent soil moisture, with Missouri River floods often preceded by a warm eastern tropical Pacific (El Niño) and Ohio River floods often preceded by a cool eastern tropical Pacific (La Niña) in the months leading up peak discharge. We also use recent floods in 2019 and 2021 to demonstrate how linking flood hazard to sea surface temperature anomalies holds potential to improve seasonal predictability of hydrologic extremes on these rivers.
Study of the Decadal Predictability of Mediterranean Sea Surface Temperature Based on Observations
Authors: Yan Xiaoqin , Tang Youmin , Yang Dejian 
Published: November 2022

Abstract
Sea surface temperature (SST) changes in the Mediterranean Sea have profound impacts on both the Mediterranean regions and remote areas. Previous studies show that the Mediterranean SST has significant decadal variability that is comparable with the Atlantic multidecadal variability (AMV). However, few studies have discussed the characteristics and sources of the decadal predictability of Mediterranean SST based on observations. Here for the first time we use observational datasets to reveal that the decadal predictability of Mediterranean SST is contributed by both external forcings and internal variability for both annual and seasonal means, except that the decadal predictability of the winter mean SST in the eastern Mediterranean is mostly contributed by only internal variability. Besides, the persistence of the Mediterranean SST is quite significant even in contrast with that in the subpolar North Atlantic, which is widely regarded to have the most predictable surface temperature on the decadal time scale. After the impacts of external forcings are removed, the average prediction time of internally generated Mediterranean SST variations is more than 10 years and closely associated with the multidecadal variability of the Mediterranean SST that is closely related to the accumulated North Atlantic Oscillation forcing.

Significance Statement
Decadal prediction of sea surface temperature (SST) in the Mediterranean Sea is very important due to its profound climate impacts. Understanding the spatial/seasonal characteristics and sources of the decadal predictability of the Mediterranean SST are crucial for skillful decadal prediction of the Mediterranean SST and related variations. This study for the first time shows that the decadal predictability of the Mediterranean SST is quite significant even in comparison with the AMV. The decadal predictability of the Mediterranean SST is both region and season dependent. The internally generated decadal predictability of the Mediterranean SST is most probably related to the local ocean dynamics.
Short-Term Ensemble Streamflow Prediction Using Spatially Shifted QPF Informed by Displacement Errors
Authors: Hugeback Kyle K. , Franz Kristie J. , Gallus William A. 
Published: November 2022

Abstract
Errors associated with the location of precipitation in QPFs present challenges when used for hydrologic prediction, particularly in small watersheds. This work builds on a past study that systematically shifted QPFs prior to inputting them into a hydrologic model to generate streamflow ensembles. In the original study, which used static, predetermined shifting distances, flood detection improved, but false alarms increased due to large ensemble spread. The present research tests a more informed approach by randomly selecting shift directions and distances based on the distribution of displacement errors from a sample of QPFs. Precipitation forecasts were taken from the High-Resolution Rapid Refresh Ensemble (HRRRE), and streamflow predictions were generated using the Weather Research and Forecasting hydrological modeling system, version 5.1.1, in a National Water Model 2.0 configuration. A 63-member streamflow ensemble was generated using the 9 original HRRRE and 54 shifted HRRRE members. Two ensemble updating schemes were tested in which ensemble member weights were adjusted using precipitation location and QPF displacement present at convective initiation. The ensembles using QPF shifted based on climatological spatial errors showed higher probabilistic forecasting skill, while having comparable dichotomous forecasting skill to the original HRRRE ensemble. Other methods of selecting nine ensemble members from the full 63-member suite did not show significant improvement. Flood peak timing showed frequent errors, with average timing errors around five hours early. Larger watersheds tended to have better skill metric scores than smaller basins, with increased skill added by the shifting of QPF.
Attribution of the Subsurface Temperature Change in the Southern Hemisphere
Authors: Chen Jia-Jia , Cheng Xuhua 
Published: November 2022

Abstract
The Southern Hemisphere temperature has experienced obvious changes with great spatial differences over the past several decades. Most regions show extreme warming, especially those located at 35°–55°S. In contrast, subsurface cooling exists between 15° and 35°S in the Indian and Pacific basins. The subsurface temperature and salinity change can be divided into spiciness change and heave components. The results show the warming due to isopycnal movement being largely offset by significant spiciness cooling at middepth. Surface warming and subduction into the interior ocean account for subsurface spiciness cooling near 45°S, while surface freshening and penetration along isopycnals are more important to the subsurface spiciness cooling farther north. The isobaric temperature change is associated with pure warming and pure heaving, and the subsurface cooling observed in the Indian and Pacific subtropics is predominantly attributed to pure heaving. This study provides a quantitative estimate of the relative contribution of surface temperature, salinity change, and circulation adjustment in subsurface temperature change, highlighting the importance of circulation change in producing subsurface cooling. Further research is needed to understand why different processes dominate in different ocean sections.

Significance Statement
While the global ocean is warming, the subsurface temperature change exhibits a significant regional disparity. This paper attempts to explain the deep-reaching warming at 35°–55°S and cooling at 15°–35°S based on three historical observation datasets. We find that the cooling mostly occurs between 400 and 1000 m in the south Indian and Pacific subtropics (15°–35°S), which is attributed to pure heaving, indicating the importance of circulation change in these regions. The midlatitude warming (35°–55°S) is mainly caused by the pure warming process, which is related to heat uptake at the subpolar surface and northward and downward heat transport. The spiciness cooling near 45°S is mainly driven by the subduction of the surface warming signal while the freshening process has a stronger impact on spiciness cooling farther north.
Resistance welding of carbon fibre reinforced PEKK by means of CNT webs
Authors: Russello M , Catalanotti G , Hawkins SC , Falzon BG 
Published: November 2022

Single lap shear specimens were manufactured using resistance welding of carbon fibre reinforced substrates by means of CNT web-based heating elements. Heating elements were manufactured by embedding the CNT web layers between layers of PEKK/glass fibre and connecting them to copper electrodes. An experimental campaign explored their electrothermal behaviour influencing the welding process. Single lap shear specimens were then welded at a pressure of 0.05 MPa and different levels of power and duration. An optimum bond was obtained with a specific power of 80–90 kW/m2 and a time of 150 s, achieving a shear strength of 30 MPa. Post-mortem analysis revealed that fracture propagated within the substrates. This work represents a further step in the integration of CNT web-based heating elements in an industrial welding process.
Comparative Analysis of Hallux Valgus Surgical Techniques: A Systematic Review
Authors: Amin Atish , Ali Shahrukh R. , Patel Mayurkumar S. , Nsekpong Tyler B. , Beasley Brian J. , Panchbhavi Vinod K. , Jupiter Daniel 
Published: November 2022

Category: Bunion; Midfoot/Forefoot Introduction/Purpose: Hallux valgus is a foot deformity where the distal portion of the hallux deviates laterally, forming a bunion. Here we review three surgical techniques for correction of the deformity: lapidus arthrodesis (LA), minimally invasive surgery (MIS), or proximal chevron osteotomy (PCO). The purpose of this study was to compare the hallux valgus angle (HVA) and intermetatarsal angle (IMA) for radiologic outcomes, and the American Orthopaedic Foot & Ankle Society Score (AOFAS) score for quality of life outcomes, between treatment groups. Methods: We performed a literature search, with strict inclusion and exclusion criteria, for identifying pertinent references. After review, and resolution of any disagreements by consensus among 5 raters, a total of 42 studies were included in this analysis. Results: The mean HVA difference (postoperative to preoperative) was 23.68 for PCO and 21.40 for LA. The mean IMA difference was 9.53 for PCO and 8.12 for LA. The mean of postoperative HVA was calculated to be11.81 for MIS and 9.13 for LA. The mean of postoperative IMA was calculated to be 8.39 for MIS and 6.60 for LA. The postoperative AOFAS mean was 86.00 for MIS and 86.46 for LA. No studies directly compared surgical methods; the results that follow describe each technique summarized separately. Conclusion: We discovered that HVA and IMA difference means were higher in PCO vs LA, with a larger difference signifying better radiologic correction. HVA and IMA postoperative means were lower in LA vs MIS. A smaller postoperative angle signifies more physiologic correction. Postoperative AOFAS means were similar in MIS vs LA. Further research should be done to evaluate an ideal procedure and explore better techniques for hallux valgus correction.
Clinical Outcomes of Fifth Metatarsal Fractures using Jones Fracture-Specific Screw vs Intramedullary Fixation
Authors: Anastasio Albert T. , Chopra Aman , Fletcher Amanda N. , Sharma Akhil , Parekh Selene G. 
Published: November 2022

Category: Midfoot/Forefoot Introduction/Purpose: Fractures of the proximal fifth metatarsal (Jones fractures) are common foot injuries in both athlete and nonathlete populations, given repetitive loading of the lateral column during gait. Intramedullary screw fixation is the current most common surgical management for Jones fractures, but high rates of nonunion and refracture as well as hardware prominence are reported with existing implant options for this fracture pattern. The Jones bolt is a novel surgical treatment for Jones fractures which aims for more anatomic fixation of this injury. The purpose of this study was to compare the Jones bolt to intramedullary screw fixation with regard to complication rates and patient reported outcomes. Methods: A retrospective single-surgeon case series was approved by our institutional review board. A sample of both athletes as well as nonathletes with proximal fifth metatarsal fractures treated with either intramedullary screw fixation or the Jones bolt was collected. Demographic data, patient reported outcomes, and complication rates were analyzed. Results: Patients reported significant improvements in both visual analog scale (VAS) and the American Orthopaedic Foot & Ankle Society (AOFAS) scores following operative fixation of Jones fractures (Table 1). The average VAS score improved from 5.4+-2.6 preoperatively to 1.4+-1.7 postoperatively (p<0.0001). The average AOFAS score improved from 59.0+-13.2 preoperatively to 186.0+-11.2 postoperatively (p<0.0001). There was no difference in final postoperative VAS (1.4 vs. 1.4; p=0.9702) or AOFAS (87.7 vs 85.7; p=0.4262) or overall change of VAS (3.8 vs. 3.5; p=0.8219) or AOFAS (20.5 vs. 25.0; p=0.6613) for Jones bolt versus all other types of fixation. Conclusion: The Jones bolt is a novel treatment for proximal fifth metatarsal fractures, with noninferior outcome scores and complication rates when compared with intramedullary screw fixation. Long-term follow-up and larger sample sizes are indicated to assess for superiority of the Jones bolt.
DNase treatment for atelectasis in infants with severe respiratory syncytial virus bronchiolitis
Authors: Merkus P.J.F.M. , de Hoog M. , van Gent R. , de Jongste J.C. 
Published: November 2022

Respiratory insufficiency due to respiratory syncytial virus (RSV) bronchiolitis is partly due to the abundance of thickened mucus and the inability to clear it from the airways. Mucus in RSV bronchiolitis contains necrotic inflammatory and epithelial cells. The viscoelastic properties of purulent airway secretions are largely due to the presence of highly polymerized deoxyribonucleic acid (DNA). Recombinant human deoxyribonuclease (rhDNase) is known to liquefy such mucus in patients with cystic fibrosis, whereas case reports described a beneficial effect in other respiratory disorders. The authors hypothesized that rhDNase would diminish atelectasis and mucus plugging in infants with severe RSV bronchiolitis.Two infants with RSV bronchiolitis with massive unilateral atelectasis in whom mechanical ventilation was imminent due to exhaustion, and three mechanically ventilated infants (two neonates, one with bronchopulmonary dysplasia) with RSV bronchiolitis with pneumonia received treatment with 2.5 mg nebulized rhDNase twice daily.Following administration of nebulized recombinant human deoxyribonuclease, clinical and radiological parameters improved quickly. Mechanical ventilation could be avoided in two infants while in three infants on artificial ventilation, clinical recovery started following the first dose of the drug. A therapeutic trial of recombinant human deoxyribonuclease may be an option in the treatment for atelectasis in severe or complicated respiratory syncytial virus bronchiolitis in infancy.