bluuebunny/crossref_metadata_2025_split huggingface dataset:
External evaluation of university quality in Chile: an overview
Authors: López Daniel A. , Espinoza Oscar , Rojas María J. , Crovetto Mirta 
Published: May 2022

Purpose
This study aims to review processes of accreditation for Chilean Universities. Along with cataloguing evolutionary milestones, the study analyses effects at the institutional and program levels.

Design/methodology/approach
The study adopts a meta-evaluative approach and is based on secondary information sources, including both specialised publications and national databases, regarding the expansion of institutions, programs and enrolment, as well as the results of accreditation processes.

Findings
University quality assurance reflects developments in economic policies, and supply and demand. Progressive consolidation of the national system has had positive effects on the management and development of universities, but the implementation of quality assurance has brought some problems. A traditional classification of universities into customary categories is predictive of the results of accreditation. The variable of administrative compliance is more important than a culture of quality in explaining the results of institutional and program accreditation.

Originality/value
This review identifies advances, limitations and challenges in the improvement and assurance of quality of Chilean Universities and their programs. This is an unprecedented metanalysis of studies concerning the evolution of accreditation processes and will inform future practice.
Tensile properties of FDM 3D-printed wood flour filled polymers and mathematical modeling through classical lamination theory
Authors: Malagutti Lorenzo , Mazzanti Valentina , Mollica Francesco 
Published: May 2022

Purpose
The architecture of 3D-printed parts made through fused deposition modelling (FDM) with raster infill resembles that of composite laminates. Classical lamination theory (CLT), the simplest model for composite laminates, has been proved successful for describing the stiffness properties of FDM parts, while strength modeling so far has been limited to unidirectional lay-ups. The aim of this paper is to show that CLT can be used to predict also FDM part failure.

Design/methodology/approach
Wood flour-filled polyester has been chosen as a model material. Unidirectional specimens oriented at 0°, 90° and ± 45° have been first characterized in simple tension to obtain the properties of the single layer. Next, two quasi-isotropic lay-ups, possessing different layer sequences, have been tested again in simple tension for CLT validation.

Findings
The measured properties are in good agreement with theoretical predictions, both for stiffness and strength, and an even better agreement can be achieved if a correction for taking the contour lines into account is implemented.

Originality/value
The paper shows that also the tensile strength of FDM parts can be predicted by using a mathematical model based on CLT. This opens up the possibility of using CLT for studying optimization of raster filled lay-ups, for example in terms of the best raster angles sequence, to better resist applied external loads.
Additive manufacturing on the façade: functional use of direct metal laser sintering hatch distance process parameters in building envelope
Authors: Çalışkan Cemal İrfan , Arpacıoğlu Ümit 
Published: May 2022

Purpose
The purpose of this article is on the functional usability of metal additive manufacturing (AM) direct metal laser sintering (DMLS) production technology process parameters in the construction industry. In the study, the advantages of thermal optimization and weight reduction in the case of the use of foam metals obtained by changing the hatch distance the production process parameter, in the production of facade panels in the architectural field are revealed.

Design/methodology/approach
The methods in the study; production of the small scaled facade panels with nine different hatch distance parameters, determination of the thermal change with the infrared thermography method, microstructure examination, weight measurement.

Findings
The paper lays the groundwork for the manufacturability of lighter and lower thermal conductivity facade panels by changing the hatch distance parameters. Within the scope of the study, the definition of semi-open-cell foam aluminum and the product screening strategy offers innovation. Within the scope of the study, this scope is shared as an algorithmic summary. In addition, the study offers a new perspective within the scope of multiple optimizable panel production in facade panels with AM technology.

Originality/value
Hatch distance parameter change was first discussed in this study in the architectural field, and a semi-open cell foam aluminum panel was obtained with the scanning strategy determined within the scope of the study. This panel geometry, which is defined as semi-open cell foam aluminum, can be used as a design element by painting or coating the outer surface, it can be stated that it will also provide thermal and weight optimization.
Mechanical anti-lock braking system using pneumatic system and solenoid valve with low cost manufacturing
Authors: K. Vinoth Kumar , T.G. Loganathan , G. Jagadeesh 
Published: May 2022

Purpose
The Purpose of this study is to prove the possibility of developing low cost mechanical anti – lock braking system (ABS) for the passenger’s safety.

Design/methodology/approach
The design methodology of the proposed newer mechanical ABS comprises of two units, namely, the braking unit and wheel lock prevention unit. The braking unit actuates the wheel stopping as and when the driver applies the brake, whereas the wheel lock prevention unit initiates wheel release to prevent locking and subsequent slip/skidding. The brake pedal with master cylinder assembly and double-arm cylinder forms the braking unit, brake pad cylinder, movable brake pad, solenoid valve and dynamo forms the wheel lock prevention unit. The dynamo coupled with the rotor energises/de-energises the solenoid values to direct airflow for applying brake and release it, which makes the system less energy-dependent.

Findings
The braking unit aids in vehicle stops, by locking the disc with the brake pad actuated by a double-arm cylinder. The dynamo energises the solenoid valve to activate the brake pad cylinder piston for applying the brake on the disc. Instantaneously, on applying the brake the dynamo de-energises the solenoid to divert the pneumatic flow for retracting the brake pad thereby minimizing the braking torque. The baking torque reduction revives the wheel rotating and prevents slip/skidding.

Originality/value
Mechanical ABS preventing wheel lock by torque reduction principle is a novel method that has not been evolved so far. The system was designed with repair/replacement of the parts and subcomponents to support higher affordability on safety grounds.
Indirect consequences of coronavirus disease 2019: Skin lesions caused by the frequent hand sanitation and use of personal protective equipment and strategies for their prevention
Authors: Graça Angélica , Martins Ana Margarida , Ribeiro Helena Margarida , Marques Marto Joana 
Published: May 2022

AbstractThe coronavirus disease 2019 (COVID‐19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) enforced the use of hand sanitation and of personal protective equipment, such as masks and visors, especially by health‐care professionals, but also by the general public. However, frequent hand sanitation and the prolonged and continuous use of personal protective equipment are responsible for constant frictional and pressure forces on skin causing lesions, the most reported being acne, facial itching, dryness, and rash. Thus, it is important to find measures to prevent skin lesions, in order to improve the quality of life of health‐care professionals and of the general public. This article gathers the current information regarding measures to prevent human to human transmission of COVID‐19, reviews the most common skin lesions caused by the use of hand sanitizers and different types of personal protective equipment, and the possible preventive measures that can be used on a daily basis to minimize the risk of developing skin‐related pathologies. Daily skin care routines and the incorporation of a dressing between the skin and the personal protective equipment to serve as a protective barrier are some of the applied measures. Moisturizers and dressings improve the skin's ability to respond to constant aggressions. Lastly, the need for additional studies to evaluate the lubrication properties of different types of dressings is discussed. The understanding of what kind of dressing is more suitable to prevent pressure injuries is crucial to promote healthy skin and wellbeing during pandemic times.
The first case of Chinese phacomatosis pigmentokeratotica diagnosed by a missense HRAS mosaicism
Authors: Huang Linting , Zhang Jia , Chen Fuying , Zhang Xue , Cao Yu , Cheng Ruhong , Deng Dan 
Published: May 2022

AbstractPhacomatosis pigmentokeratotica (PPK) is a rare epidermal nevus (EN) syndrome, featured by co‐occurrence of speckled lentiginous nevus (SLN) and nevus sebaceous (NS). The underlying mechanism has not been clarified. Pathogenic mutations in HRAS, KRAS and BRAF gene are recently recognized as the genetic cause of PPK. Here we present a case of Chinese PPK with a mosaic mutation in HRAS gene. Physical examination of the 4‐year‐old male proband showed NS locating on the scalp, with EN and SLN on trunk and extremities. Except congenital fundus vascular tortuosity, no evidence of extracutaneous abnormalities was found in this case. A rare heterozygous missense c. 181 C>A mosaic mutation in HRAS was identified in samples from NS, EN and pigmented nevus using next‐generation sequencing and Sanger sequencing. Meanwhile, no mutation was found in the non‐lesion skin, hair follicle, or blood DNA. Recent breakthrough in clinical manifestation, genetic mutation and prognosis of PPK is also reviewed.
Circ_0001273 downregulation inhibits the growth, migration and glutamine metabolism of esophageal cancer cells via targeting the miR‐622/SLC1A5 signaling axis
Authors: Wu Bomeng , Chen Ying , Chen Ying , Xie Xihao , Liang Hanping , Peng Fengyuan , Che Weibi 
Published: May 2022

AbstractBackgroundEsophageal cancer is a relatively rare cancer. However, its death rate is not to be taken lightly. Accumulating evidence indicates circular RNA (circRNA) is implicated in cancer development. The objective of this study was to unveil the role of circ_0001273 in esophageal cancer (EC).MethodsFor expression analysis of circ_0001273, miR‐622 and solute carrier family 1 member 5 (SLC1A5), quantitative real‐time PCR (qPCR) and Western blot were conducted. Cell proliferation was evaluated by cell counting kit‐8 (CCK‐8), EdU and colony formation assays. Cell apoptosis and cell migration were investigated using flow cytometry assay and wound healing assay. Glutamine metabolism was assessed by glutamine consumption and glutamate production using matched kits. The predicted binding relationship between miR‐622 and circ_0001273 or SLC1A5 was validated by dual‐luciferase reporter assay. An in vivo xenograft model was established to determine the role of circ_0001273 on tumor growth.ResultsCirc_0001273 was upregulated in EC tumor tissues and cells. Knockdown of circ_0001273 repressed EC cell proliferation, migration, epithelial‐mesenchymal transition (EMT) and glutamine metabolism. Circ_0001273 knockdown also blocked tumor development in animal models. MiR‐622 was targeted by circ_0001273, and its inhibition reversed the functional effects of circ_0001273 knockdown. SLC1A5 was a target gene of miR‐622, and circ_0001273 targeted miR‐622 to positively regulate SLC1A5 expression. The inhibitory effects of miR‐622 enrichment on EC cell proliferation, migration, EMT and glutamine metabolism were recovered by SLC1A5 overexpression.ConclusionCirc_0001273 high expression contributed to EC progression via modulating the miR‐622/SLC1A5 signaling axis.
Use of free modified jejunal flaps to reconstruct pharyngoesophageal defects with preservation of the larynx in three cases
Authors: Liu Jifeng , Yu Rong , Wang Ji , Deng Di , Li Linke , Li Bo , Liu Jun , Chen Fei 
Published: May 2022

AbstractThe larynx is often sacrificed in patients with hypopharyngoesophageal cancer before reconstruction using the jejunum to restore the continuity of the digestive tract and allow oral alimentation. We retrospectively collected and analyzed data from three patients who underwent hypopharyngoesophageal reconstruction by partial patch and partial tube free jejunal flap with preservation of laryngeal function. All three flaps survived in patients who underwent the modified jejunal flaps. The larynx was preserved in all three patients. Partial patch and partial tube jejunal flap is a possible option for reconstruction of large and complex defects after pharyngectomy and cervical esophagectomy with larynx preservation.
A large intrathoracic goiter with tracheal stenosis: Complete resection using a robot‐assisted thoracoscopic approach
Authors: Nakamura Ryuji , Okuda Katsuhiro , Chiba Kensuke , Matsui Takuya , Oda Risa , Tatematsu Tsutomu , Yokota Keisuke , Nakanishi Ryoichi 
Published: May 2022

AbstractGrowing intrathoracic goiters may compress surrounding organs and deteriorate the cardiopulmonary function. Treating such cases requires carefully considering how to maintain oxygenation and resect the tumor with minimal invasiveness without complications. We herein report a surgically resected case of a large intrathoracic goiter‐compressed trachea extending from the right lower pole of the thyroid gland to the carina. We secured the airway by intubation preparing for extracorporeal membrane oxygenation and successfully performed surgical complete resection using a robot‐assisted thoracoscopic and cervical approach. Intrathoracic goiter is a tumor with abundant neovascularity, and the right vagus nerve is displaced in the thoracic cavity, but a robot‐assisted thoracoscopic approach using CO2 insufflation improved visualization at the narrow apex area of the thoracic cavity. Robot‐assisted thoracoscopic surgery is a useful surgical procedure enabling safe and minimally invasive surgery without recurrent laryngeal nerve palsy or tracheal injury for intrathoracic giant goiters extending into the thoracic cavity.
Theta oscillatory dynamics of inhibitory control, error processing, and post‐error adjustments: Neural underpinnings and alcohol‐induced dysregulation in social drinkers
Authors: Marinkovic Ksenija , Rosen Burke Q. 
Published: May 2022

AbstractBackgroundAlcohol intoxication impairs inhibitory control, resulting in disinhibited, impulsive behavior. The anterior cingulate cortex (ACC) plays an essential role in a range of executive functions and is sensitive to the effects of alcohol, which contributes to the top‐down cognitive dysregulation. This study used a multimodal approach to examine the acute effects of alcohol on the neural underpinnings of inhibitory control, inhibition failures, and neurobehavioral optimization as reflected in trial‐to‐trial dynamics of post‐error adjustments.MethodsAdult social drinkers served as their own controls by participating in the Go/NoGo task during acute alcohol and placebo conditions in a multi‐session, counterbalanced design. Distributed source modeling of the magnetoencephalographic signal was combined with structural magnetic resonance imaging to characterize the spatio‐temporal dynamics of inhibitory control in the time‐frequency domain.ResultsSuccessful response inhibition (NoGo) elicited right‐lateralized event‐related theta power (4 to 7 Hz). Errors elicited a short‐latency increase in theta power in the dorsal (dACC), followed by activity in the rostral (rACC), which may underlie an affective “oh, no!” orienting response to errors. Error‐related theta in the dACC was associated with subsequent activity of the motor areas on the first post‐error trial, suggesting the occurrence of post‐error output adjustments. Importantly, a gradual increase of the dACC theta across post‐error trials closely tracked improvements in accuracy under placebo, which may reflect cognitive control engagement to optimize response accuracy. In contrast, alcohol increased NoGo commission errors, dysregulated theta during correct NoGo withholding, and abolished the post‐error theta enhancement of cognitive control.ConclusionsConfirming the sensitivity of frontal theta to inhibitory control and error monitoring, the results support functional and temporal dissociation along the dorso‐rostral axis of the ACC and the deleterious effects of alcohol on the frontal circuitry subserving top‐down regulation. Over time, alcohol‐induced disinhibition may give rise to compulsive drinking and contribute to alcohol misuse.
Patterns and predictors of alcohol use during the early stages of the COVID‐19 pandemic in Australia: Longitudinal cohort study
Authors: Batterham Philip J. , Shou Yiyun , Farrer Louise M. , Murray Kristen , Morse Alyssa R. , Gulliver Amelia , Slade Tim , Newton Nicola C. , Calear Alison L. 
Published: May 2022

AbstractBackgroundThe COVID‐19 pandemic has resulted in disruptions across many life domains. The distress associated with the pandemic itself, and with public health efforts to manage the outbreak, could result in increased alcohol use. This study aimed to quantify changes in alcohol use during the early stages of the pandemic and factors associated with different patterns of use.MethodsData were obtained from a longitudinal survey of a representative Australian adult sample (N = 1296, 50% female, Mage = 46.0) conducted from March to June 2020, during the first wave of the COVID‐19 outbreak in Australia. Change in alcohol consumption was examined using Alcohol Use Disorders Identification Test‐Consumption (AUDIT‐C) scores from waves one, three, five, and seven of the study, each 4 weeks apart. Factors associated with alcohol consumption were examined, including depression (PHQ‐9) and anxiety (GAD‐7) symptoms, health risk tolerance, stress and coping, work and social impairment (WSAS), COVID impacts, and sociodemographic variables. We tested changes in alcohol use across the full sample using a mixed effects repeated measure ANOVA model and a multinomial logistic regression to identify factors assessed at wave 1 that were independently associated with alcohol use.ResultsThere was no significant change in AUDIT‐C scores across the study. For most participants, alcohol use did not increase during the early phase of the COVID‐19 pandemic in Australia. COVID‐19 exposure, higher perceived coping, depression symptoms, and male gender were associated with greater odds of increasing or elevated levels of alcohol use. Social changes, which included working from home, had mixed effects on alcohol consumption.ConclusionsAlthough no evidence was found for increased alcohol use overall during the early months of the pandemic, several factors were associated with alcohol consumption at risky levels. Greater understanding of motivations for drinking across public and private contexts, along with targeted support for high‐risk groups, could assist in reducing harm associated with alcohol consumption.
Hidradenitis suppurativa and Down syndrome in a single‐centre sample: A cross‐sectional study
Authors: Hernández‐Rodríguez Juan‐Carlos , Osorio‐Gómez Guiovana‐Fernanda , Ortiz‐Álvarez Juan , Lebrón‐Martín José‐Antonio , Conejo‐Mir Julián , Pereyra‐Rodríguez José‐Juan 
Published: May 2022

AbstractDown syndrome (DS) has been related to a higher risk of hidradenitis suppurativa (HS). This cross‐sectional study assessed DS patients with HS in a Spanish single‐centre sample. DS participants presented a lower age of onset, age at diagnosis and time to diagnosis. Also, DS was not associated with the severity of HS measured by baseline IHS4.
PD‐1 mediates decidual γδ T cells cytotoxicity during recurrent pregnancy loss
Authors: Guo Rong , Jiang Silin , Zhang Jianliang , Yang Quanli , Gao Liang , Xia Wei , Tong Lingxia , Feng Peiran , Xu Yan , Zhang Tao , Cheng Hao , Liu CuiPing , Zhang Xueguang , Yin Zhinan , Zhang Hong 
Published: May 2022

AbstractProblemRecurrent pregnancy loss (RPL) is one of the big challenges of normal pregnancy. Immune dysregulation has been proposed for the key underline mechanisms of RPL. However, the essential roles of T cells, especially γδ T cells, have not been defined.Method of studyDecidua were obtained from normal pregnancy women or recurrent pregnancy loss patients and the surface molecules of γδ T cells in decidua were evaluated via flow cytometric analysis. The expression of PD‐1 in clinical samples was analyzed by immunohistochemistry assay. The intracellular cytokines of decidual PD‐1+ and PD‐1‐ γδ T cells were evaluated by flow cytometric analysis. The cytotoxicity of PD‐1‐ γδ T cells were confirmed via an in vitro co‐culture experiment. The specific inhibitors for Erk, p38 and JNK against the MAPK pathway were added to the co‐culture media to evaluate the functions of the Erk, p38 and JNK.ResultsWe demonstrated that PD‐1 was significantly decreased on decidual tissue γδ T cells of patients with RPL, resulting in the enhanced cytotoxicity of γδ T cells against trophoblasts. We further elucidated an Erk‐dependent TNF‐α production mediates the γδ T cell cytotoxicity against the trophoblast cells. Finally, the reduced expression of PD‐L1 in the villi tissues of patients with RPL might be the cause of the reduction of PD‐1 on the tissue γδ T cells.ConclusionOur study uncovers an important role of PD‐1 expression on decidual γδ T cells in maintaining the normal pregnancy, and may provide a new strategy for immune therapy against RPL.
Expression of antimicrobial peptides in the amniotic fluid of women with cervical insufficiency
Authors: Kim Youngmi , Lee Keun‐Young , Lee Jae Jun , Tak Hyunjin , Park Sung‐Taek , Song Ji‐Eun , Son Ga‐Hyun 
Published: May 2022

AbstractProblemCervical insufficiency (CI) is associated with intra‐amniotic infection or inflammation. Antimicrobial peptides (AMPs) in amniotic fluid may protect the fetus against microbial invasion, giving their broad‐spectrum microbiocidal properties. We evaluated changes in amniotic fluid AMP expression in women with CI and assessed whether these changes are related to their pregnancy outcomes.Method of StudyWe evaluated amniotic fluid human neutrophil peptide 3 (HNP‐3), human β‐defensin‐2 (hBD‐2), and LL‐37 levels in 66 women with CI and 25 normal controls at 16–24 weeks of gestation. The CI group was divided into short cervix and cervical dilation groups, and the cervical dilation group was further divided into preterm and full‐term delivery groups according to the pregnancy outcomes, and AMP expression was analyzed in each group.Results: HNP‐3 and hBD‐2 levels were higher in women with CI than in normal controls and in the cervical dilation as compared to the short cervix group. Among women with cervical dilation, 22 delivered at full‐term, and 23 had spontaneous preterm births. The hBD‐2 level in amniotic fluid mid‐pregnancy was higher in the full‐term delivery than in the preterm delivery groups. However, LL‐37 levels in amniotic fluid were low in women with CI and normal controls.Conclusions: Amniotic fluid HNP‐3 and hBD‐2 levels increased in women with CI compared with normal controls. Moreover, increased amniotic fluid hBD‐2 levels mid‐pregnancy were associated with favorable pregnancy outcomes in women with CI. AMPs in the amniotic fluid may participate in host defense against ascending infection in women with CI.