bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thymic Lesions in Myasthenia Gravis: A Clinicopathological Study from India
Authors: Nishadham Vikas , Bardhan Mainak , Polavarapu Kiran , Vengalil Seena , Nashi Saraswati , Menon Deepak , Ganaraja Valakunja Harikrishna , Preethish-Kumar Veeramani , Valasani Ravi Kiran , Huddar Akshata , Unnikrishnan Gopi Krishnan , Thomas Abel , Saravanan Akshaya , Kulanthaivelu Karthik , Nalini Atchayaram , Nandeesh Bevinahalli Nanjegowda 
Published: April 2022

Background and Objectives: Thymic pathology is common in Myasthenia Gravis(MG) and plays a crucial role in its pathogenesis and clinical outcome. This study aims to discuss the clinicohistopathological spectrum of thymic lesions in MG. Methods: In this retrospective study, MG patients who underwent thymectomy from 2011 to 2020 were included. Clinical, radiological, serological, and histopathological details are described. Results: Of 83 patients( F = 45; M = 38), 7(8%) had ocular myasthenia, and the remaining 76(92%) had the generalized form. At onset, the median age was 36 years( M = 44; F = 31). AChR antibody was positive in 71/79 patients. RNST showed decrement response in 68/78 patients. The histopathological study demonstrated thymoma in 44(53%), thymic hyperplasias [32(38%)], involuted thymus [5(6%)], thymic cyst (1) and thymic lipoma (1). WHO grading of thymoma: B2- 48%, AB-18%, B-18%, B3-14%, A-2.3%. In these, capsular infiltration was noted in 11/44, 9 had focal and 2 had diffuse infiltration. Active germinal centers were present in 20/32 patients with thymic hyperplasia and 4/44 with thymoma. Thymomas were predominant in males and thymic hyperplasia in females. The age of onset and antibody positivity rate was higher in thymoma patients. Conclusion: In our cohort, there is a female preponderance. Thymoma was the commonest pathology followed by hyperplasia. We observed earlier onset of myasthenia in females. AChR antibody positivity rate was more frequent in thymomas. This study indicates that clinico-radiological evaluation adequately supported by serology and histopathology can effectively recognize the type of thymic pathology that can guide these patients’ treatment planning, management, prognosis and follow-up.
УКРАЇНСЬКОМОВНА АДАПТАЦІЯ КАЛІФОРНІЙСЬКОГО ПСИХОЛОГІЧНОГО ОПИТУВАЛЬНИКА ДЛЯ ВИКОРИСТАННЯ В РОБОТІ З ПЕРСОНАЛОМ ОРГАНІВ МВС УКРАЇНИ
Authors: Барко В.І. , Барко В.В. , Макаренко П. , Бондаренко В. 
Published: April 2022

Стаття присвячена питанню українськомовної адаптації психодіагностичної методики «Каліфорнійський психологічний опитувальник» (СРІ) в межах вдосконалення системи психологічного забезпечення роботи з персоналом органів системи МВС України. У нашій країні дотепер не розроблено українськомовних варіантів цього опитувальника, хоча його діагностичний потенціал досить значний і може використовуватися в правоохоронних органах держави Автори статті докладно розкривають теоретичні основи і внутрішню структуру експериментального дослідження, в якому взяли участь більше трьохсот співробітників Національної поліції України з різних підрозділів (патрульної та кримінальної поліції, дільничних інспекторів). В статті наводиться україномовний текст опитувальника (СРІ-U) і ключі до нього. Основні шкали СРІ-U, яких є двадцять, групуються в чотири категорії – а) відносини з іншими - свідчить про ступінь врівноваженості, упевненості в собі, б) управління собою - виявляє пристосованість, зрілість, соціальну відповідальність особи; в) мотивація - визначає здатність до самореалізації; г) особистісні характеристики - виявляє деякі характерологічні особливості працівника. Латентно-структурний тверджень оригінального варіанту СРІ дозволив виокремити ті, котрі чітко належать певним шкалам, із числа останніх були відібрані 134 твердження, які виявились найбільш зрозумілими українськомовним респондентам і в рівній мірі відображували усі шкали опитувальника СРІ-U. Також у статті представлено середньостатистичні тестові норми, а також основні психометричні характеристики адаптованого СРІ-U - критеріальну і конструктну валідність, надійність (ретестову і паралельних форм), внутрішню узгодженість шкал тощо). Показано, що за результатами виконання СРІ-U психолог може встановити, до якого особистісного типу належить респондент: високі і середні індекси за шкалами стенічного типу реагування і низькі за шкалами гіпостенічного регістру дозволяють віднести особу до альфа-чи гамма- типу; низькі значення за стенічними шкалами шкалами і високі за гіпостенічними - означають належність особи до бета- або дельта-типів. Відзначається, що більшість працівників поліції продемонстрували показники за альфа- (55-65%) і гамма- (16-18%) типами особистості, які є продуктивними для правоохоронної діяльності і характеризуються екстравертованістю, активністю, лідерськими тенденціями, енергійністю тощо. Результати дослідження довели діагностичну верифікацію зазначеного опитувальника і доцільність його використання у процесі психологічного забезпечення роботи з персоналом органів системи МВС України.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS APLIKASI ANDROID MENGGUNAKAN SOFTWARE SMART APPS CREATOR 3 (SAC) MATERI SISTEM TATA SURYA KELAS VI SEKOLAH DASAR
Authors: Widiansyhrani Wewin 
Published: April 2022

Tujuan penelitian ini diantaranya: 1) mendeskripsikan aspek yang digunakan untuk mengembangkan media pembelajaran sustem tata surya, 2) mendeskripsikan rancangan media pembelajaran sistem tata surya, 3) mendeskripsikan uji kelayakan media pembelajaran sistem tata surya, dan 4) mendeskripsikan hasil refleksi media pembelajaran tata surya. Penelitian ini memberikan wawasan dan pengetahuan mengenai proses pembuatan media pembelajaran berbasis android menggunakan software Smart Apps Creator, guru mendapatkan kemudahana dalam menyampaikan materi melalui media ini dan memberikan motivasi belajar kepada peserta didik.
Metode penelitian dan pengembangan atau Research and Development (R&D). Research and Development adalah metode penelitian untuk menghasilkan produk dan menguji keefektifan produk yang dihasilkan (Sugioyono, 2016:407). Menurut Nana Syaodih Sukmadinata (2009: 164), Research and Development (R&D) merupakan suatu proses atau langkah-langkah untuk mengembangkan suatu produk baru atau menyempurnakan produk yang telah ada, yang dapat dipertanggungjawabkan. langkah-langkah penelitian dan pengembangan yang digunakan adalah berdasarkan model ADDIE, yaitu Analysis (Analisis), Design (Desain), Development (Pengembangan), Implementation (Implementasi), dan Evaluation (Evaluasi).
PERENCANAAN STABILISASI DAN PERKUATAN TANAH DASAR JALUR KERETA API
Authors: Arisikam Dicky , Purwadinata Awan Hermawan , Mulyawati Isah Bela 
Published: April 2022

Jalan kereta api umumnya dibangun di atas subgrade yang memiliki daya dukung tinggi agar dapat menahan beban dan mencegah penurunan ballast sehingga rel tetap pada tempatnya. Fakta di lapangan menunjukkan bahwa kebutuhan jalan rel semakin meningkat dan beberapa lokasi jalan kereta api sangat mungkin dibangun di atas tanah lempung lunak sehingga rentan mengalami ketidakstabilan tanah seperti amblesan di sepanjang jalur hilir yang terjadi pada daerah rawan KM 348+200 s.d. 349+600 di Emplasemen Stasiun Talang Padang Divre III Palembang. Penanganan yang bisa dilakukan dengan penambahan perkuatan pada tanah untuk meningkatkan daya dukung yang dapat menahan beban dinamis kereta api. Penelitian ini membahas mengenai metode penanganan dengan tiga alternatif yaitu (1) metode perkuatan tanah alternatif ke-1 menggunakan pelat beton dan kayu gelam, (2) metode perkuatan tanah alternatif ke-2 menggunakan matras bambu dan kayu gelam, (3) metode perkuatan tanah alternatif ke-3 menggunakan portal dan geotextile. Analisis perhitungan dilakukan menggunakan program PLAXIS 2D CE V20 dengan tiga alternatif penanganan. Hasil penelitian yang diperoleh yaitu (1) alternatif ke-1 deformasi sebesar 29.51 cm dengan faktor keamanan 1.398, (2) alternatif ke-2 deformasi sebesar 31.56 cm dengan faktor keamanan 1.445, (3) alternatif ke-3 deformasi sebesar 0.71 cm dengan faktor keamanan 2.237. Berdasarkan ketiga alternatif, metode yang dapat dilakukan untuk karakteristik tanah pada lokasi studi yaitu alternatif ke-3 dengan menggunakan portal dan geotextile, dimana FK > 1.5 melebihi nilai faktor keamanan minimum.
Analisis Pengaruh Likuiditas, Solvabilitas dan Aktivitas terhadap Profitabilitas pada Perusahaan Manufaktur Makanan yang Terdapat di Bei Periode 2017-2020
Authors: Novita Herlina , Gaol Rokky Lumban , Matanari Ramahmo , Siahaan Monalisa , Sarumaha Delkawati 
Published: April 2022

This research was conducted on food and beverage company that listed in Bursa Efek Indonesia,i This research aims to examine and analyze the effect of Current Rasio, Debt to Asset, Debt to Equity, Total Aset Turn Over on return of Asset. The Approach that taken in this research is quantitative and descriptive approach, population in this research are 30 companies with using purposive sampling technique and the sample amounted to 24 companies, so the total number of observations was 96 observations. However, due to the data being too extreme, somedata had to be removed in this observation by recovering 18 data’s so the total of observations used in every test are 78 data. The analytical Method that use in this research is multiple value regression method. From the result of this research simultaneously Current Rasio (CR), Debt to Asst (DAR), Debt to Equity (DER) and total Asset Turn Over (TATO) have a positive effect on Return on Assets (ROA) listed on the BEI period 2017-2020, with the result of F-hitung > F-table (2,697>2,50) with a significance value of 0,037 < 0,05. And from the partial test result that CR, DAR, DER, TATO have a no significant negative effect on ROA.
Clinical Characteristics, Laboratory Findings, and Prognosis in Patients With Talaromyces marneffei Infection Across Various Immune Statuses
Authors: Li Dianwu , Liang Huaying , Zhu Yiqun , Chang Qinyu , Pan Pinhua , Zhang Yan 
Published: April 2022

ObjectiveTalaromyces marneffei (TM) is an opportunistic fungus that is predominantly prevalent among patients who are HIV-positive in South-East Asia. However, few studies focused on the clinical features, laboratory findings, and prognosis across varying immune states.MethodsA total of 54 patients with TM infection in Xiangya Hospital of Central South University from January 1, 2006 to October 31, 2021 were retrospectively analyzed. Clinical profiles were compared across the different immune statuses by HIV-positive (HIV group, n = 18), HIV negative but with immunocompromised conditions (Non-HIV with IC Group, n = 11), and immunocompetent patients (n = 25).ResultsAll the patients were diagnosed by pathogen culture or by metagenomic next-generation sequencing (mNGS). The median age was 50, and patients with HIV were much younger compared to the other two groups. The most common symptom at presentation was fever (79.6%), followed by cough (70.4%), weight loss (61.1%), and expectoration (53.7%). The patients with HIV were more likely to develop into a subtype of disseminated TM affecting multiple organs including lymph node, liver, skin, and spleen, thus, resulting in higher hospital mortality compared to the other two groups. Patients without HIV but with immunocompromised conditions presented similar hospital mortality rates compared to immunocompetent patients, while experiencing longer days of hospitalization to recover from the diseases. Additionally, in this study, the pathogen culture easily confirmed the patients with HIV. However, mNGS presented as a promising tool to confirm TM infection in those suspicious patients without HIV.ConclusionsIn summary, patients with HIV were more likely to develop into disseminated TM, resulting in higher mortality compared to those patients without HIV. Additionally, mNGS presented as an important supplementary tool to confirm TM infection in patients without HIV, particularly in those with immunocompromised diseases.
The Effect of Chinese Medicinal Formulas on Biomarkers of Oxidative Stress in STZ-Induced Diabetic Kidney Disease Rats: A Meta-Analysis and Systematic Review
Authors: Zhou Qian , Han Chuyi , Wang Yanmei , Fu Shunlian , Chen Yiding , Chen Qiu 
Published: April 2022

BackgroundDiabetic kidney disease (DKD), defined broadly as persistent proteinuria with low estimated glomerular filtration rate in patients with diabetes, is a main cause of end-stage renal disease. Excessive production of reactive oxygen species is an important mechanism underlying the pathogenesis of DKD and many antioxidants have been investigated as therapeutic agents. Among them, Chinese medicine antioxidative stress therapies have been widely used to combat DKD, which may offer new insights into therapeutic development of DKD. There are several discrepancies among the efficacy of Western medicine (WM) and Chinese medicinal formula (CMF) action.MethodsWe searched PubMed, Cochrane Library, the Web of Science databases, Embase, and Scopus from inception to December 2021 using relevant keywords and a comprehensive search for randomized controlled trials (RCTs) was performed. Calculating the pooled weighted mean difference (MD) and 95% CI by the method of inverse-variance with a random-effect. All the related statistical analyses were performed using Stata version 15.1 software (Stata Corporation) and Rvman version 5.3 (Nordic Cochrane Center).ResultsA total of 8 articles with the 9 groups including 106 in the model group, 105 in the CMF group, and 99 in the WM group. Pooled data from 8 studies (9 groups) showed a statistical improvement in superoxide dismutase compared with the model group [standardized MD (SMD) = 1.57; 95 CI: 1.16–1.98; P &lt; 0.05] and the WM group (SMD = 0.56; 95 CI: 0.19–0.92; P &lt; 0.05). For glutathione peroxidase (GSH-Px), it was significantly improved in the CMF group vs. the model group and the WM group. For malondialdehyde (MDA), it was significantly reduced in the CMF group (CMF vs. model group: SMD = −1.52; 95 CI: −1.88 −1.17; P &lt; 0.05; CMF vs. WM group: SMD = −0.64; 95 CI: −0.95 −0.33; P &lt; 0.05).ConclusionThis systematic review and meta-analysis have demonstrated that the therapy of CMF had a notable curative effect on relieving oxidative stress in STZ-induced DKD rats and CMF was significantly more effective than the WM control group. For the clinical application, the results providing confidence and some theoretical reference for DKD via evaluating the efficacy of CMF to a certain extent.Systematic Review Registration[PROSPERO], identifier [CRD42022313737].
Clinicopathological and Prognostic Significance of Stromal Patterns in Oral Squamous Cell Carcinoma
Authors: Amano Yusuke , Kihara Atsushi , Hasegawa Masayo , Miura Tamaki , Matsubara Daisuke , Fukushima Noriyoshi , Nishino Hiroshi , Mori Yoshiyuki , Niki Toshiro 
Published: April 2022

BackgroundStromal patterns (SP), especially desmoplastic reactions, have recently gained attention as indicators of malignant potential in cancer. In this study, we explored the clinicopathological and prognostic significance of the SP in oral squamous cell carcinoma (OSCC).Materials and MethodsWe reviewed 232 cases of surgically resected OSCC that were not treated with neoadjuvant chemoradiotherapy. We categorized the SP of the OSCC into four groups: immune/inflammatory (84 cases), mature (14 cases), intermediate (78 cases), or immature (56 cases).ResultsThe SP category was significantly associated with various clinicopathological factors, such as the histological grade, lymphovascular invasion, neural invasion, and a diffuse invasion pattern. For each of the factors, the immune/inflammatory type was associated with favorable categories, while the immature type was associated with unfavorable categories (p ≤ 0.001). The SP category was also shown to be a prognostic predictor: the 5-year relapse-free survival (RFS) rate was 72.0% for the immune/inflammatory type, 66.7% for the intermediate/mature type, and 31.2% for the immature type (p &lt; 0.0001), and the 5-year overall survival (OS) rate was 85.1% for the immune/inflammatory type, 76.4% for the intermediate/mature type, and 50.0% for the immature type (p &lt; 0.0001). In multivariate analyses, the SP category was identified as an independent prognostic factor for RFS and OS.ConclusionOur SP categorization method provides valuable prognostic information in OSCC.
Alterations of Striatal Subregions in a Prion Protein Gene V180I Mutation Carrier Presented as Frontotemporal Dementia With Parkinsonism
Authors: Chen Zhongyun , Ma Jinghong , Liu Li , Liu Shuying , Zhang Jing , Chu Min , Wang Zhen , Chan Piu , Wu Liyong 
Published: April 2022

ObjectiveTo explore the roles of striatal subdivisions in the pathogenesis of frontotemporal dementia with parkinsonism (FTDP) in a patient resulting from prion protein gene (PRNP) mutation.MethodsThis patient received clinical interviews and underwent neuropsychological assessments, genetic testing, [18F]-fluorodeoxyglucose positron emission tomography ([18F]-FDG PET)/MRI, and [18F]-dihydrotetrabenazine positron emission tomography ([18F]-DTBZ PET)/CT. Region-of-interest analysis was conducted concerning metabolism, and dopamine transport function between this patient and 12 controls, focusing on the striatum subregions according to the Oxford-GSK-Imanova Striatal Connectivity Atlas.ResultsA 64-year-old man initially presented with symptoms of motor dysfunction and subsequently behavioral and personality changes. FTDP was initially suspected. Sequence analysis disclosed a valine to isoleucine at codon 180 in PRNP. Compared to controls, this patient had a severe reduction (&gt; 2SD) of standard uptake value ratio (SUVR) in the limbic and executive subregions but relative retention of metabolism in rostral motor and caudal motor subregions using [18F]-FDG PET/MRI, and the SUVR decreased significantly across the striatal in [18F]-DTBZ PET/CT, especially in the rostral motor and caudal motor subregions.ConclusionThe alteration of frontal striatal loops may be involved in cognitive impairment in FTDP, and the development of parkinsonism in FTDP may be primarily due to the involvement of the presynaptic nigrostriatal loops in PRNP V180I mutation.
Effects of Rhythmic Auditory Stimulation on Gait and Motor Function in Parkinson's Disease: A Systematic Review and Meta-Analysis of Clinical Randomized Controlled Studies
Authors: Wang Lei , Peng Jin-lin , Ou-Yang Jian-bin , Gan Li , Zeng Shuai , Wang Hong-Yan , Zuo Guan-Chao , Qiu Ling 
Published: April 2022

ObjectiveThis study aimed to summarize the effectiveness of rhythmic auditory stimulation (RAS) for the treatment of gait and motor function in Parkinson's disease (PD) through a systematic review and meta-analysis.MethodsAll studies were retrieved from eight databases. The effects of RAS on PD were determined using the following indicators: gait parameters including step length, stride width, step cadence, velocity, stride length; motor function including 6 min walk test (6MWT) and timed up-and-go test (TUGT); the Unified Parkinson's Disease Rating Scale (UPDRS); and the Berg Balance Scale (BBS). The risk map of bias of the quality of the studies and the meta-analysis results of the indicators was prepared with RevMan 5.2 software.ResultsTwenty-one studies were included in the systematic review, and 14 studies were included in the meta-analysis. In the meta-analysis, the results of gait parameters, namely, velocity, step length, and stride length, were statistically significant (P &lt; 0.05), whereas the results of cadence and stride width were not statistically significant (P ≧ 0.05). The results of 6MWT and TUGT for motor function as well as UPDRS-II, UPDRS-III, and BBS were statistically significant (P &lt; 0.05).ConclusionsRAS could improve gait parameters, walking function, balance function, and daily living activities of individuals with PD. The application of RAS in conventional rehabilitation approaches can enhance motor performance in PD. Future studies should use a large sample size and a rigorous design to obtain strong conclusions about the advantages of RAS for the treatment of gait and motor function in PD.
Creutzfeldt-Jakob Disease: Alterations of Gut Microbiota
Authors: Guo Yanjun , Xu Yichen , Lin Xue , Zhen Zhen , Yi Fang , Guan Hongzhi , Shi Qi , Sun Wenjie , Yang Anchao , Dong Xiaoping , Wang Jiawei 
Published: April 2022

IntroductionHuman gut dysbiosis has been implicated with the onset of many neurodegenerative disorders. However, the current data focused on the gut microbiota of patients with Creutzfeldt-Jakob disease (CJD) are still lacking. In our study, we explored the gut microbiota alteration in patients with CJD.MethodWe performed 16S ribosomal RNA MiSeq sequencing in stool samples of patients with CJD and controls. Functional analysis of the gut microbiota between these two groups was based on Kyoto Encyclopedia of Genes and Genomes and Phylogenetic Investigation of Communities by Reconstruction of Unobserved States 2. Clinical rating scales were used to evaluate the association between cognitive impairment and gut microbiota alteration.ResultWe identified a significant alteration in both the structure and the richness of the CJD group. Function analysis revealed that the gut microbiota of patients with CJD enriched in immune signaling molecule interactions and xenobiotics biodegradation. MoCA and survival times were found to be associated with gut microbiota in patients with CJD.ConclusionWe demonstrated an altered gut microbiota in patients with CJD, which was associated with the cognitive impairment and the survival time of these patients.