bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taxillus chinensis (DC.) Danser: a comprehensive review on botany, traditional uses, phytochemistry, pharmacology, and toxicology
Authors: Qin Mi , Huang Qianqian , Yang Xin , Yu Lu , Tang Yong , Zhang Chunxiang , Qin Dalian , Zou Wenjun , Deng Junzhu , Liu Jian , Hu Haiyang , Wang Long , Wu Anguo , Wu Jianming 
Published: December 2022

Abstract
Background
Taxillus chinensis (DC.) Danser (T. chinensis), known as “Sangjisheng” in Chinese, is a member of the family Loranthaceae, with the traditional functions of “dispelling wind dampness, strengthening bones and muscles, and preventing miscarriage”. Since Eastern Han dynasty, it has been used for the treatment of rheumatoid arthritis, arthralgia, threatened abortion, and hypertension. Nowadays, T. chinensis is included in the 2020 Edition of the Chinese Pharmacopoeia as Taxilli Herba. The purpose of this review is to summarize the latest research on T. chinensis in recent years, and make critical comments, so as to provide reference for the clinical application and modern research of T. chinensis.

Main body
In this review, we summarize the botany, traditional uses, and research advances in the phytochemistry and pharmacological effects of T. chinensis. Its toxicity has also been discussed. The published literature on current pharmacological and toxicological data has also been assessed. To date, approximately 110 compounds, including flavonoids, phenolic acids, phenylpropanoids, tannins, glycosides, amino acids, and nucleosides, have been identified in T. chinensis. Flavonoids are considered the most vital bioactive ingredients in T. chinensis. Pharmacological studies have demonstrated that T. chinensis possesses anti-inflammatory, antioxidant, anticancer, antimicrobial, antiviral, diuretic, antihypertensive, antihyperglycemic, and other properties.

Conclusion
Currently, research on T. chinensis is in the preliminary stages, and further research is required to understand the active compounds present and mechanisms of action. We hope that this comprehensive review of T. chinensis will serve as a background for further research.
Therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance
Authors: Fu Kai , Xie Fachao , Wang Fang , Fu Liwu 
Published: December 2022

AbstractEpidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are the preferential options for advanced non-small cell lung cancer (NSCLC) patients harboring EGFR mutations. Osimertinib is a potent irreversible third-generation EGFR-TKI targeting EGFR mutations but has little effect on wild-type EGFR. In view of its remarkable efficacy and manageable safety, osimertinib was recommended as the standard first-line treatment for advanced or metastatic NSCLC patients with EGFR mutations. However, as the other EGFR-TKIs, osimertinib will inevitably develop acquired resistance, which limits its efficacy on the treatment of EGFR-mutated NSCLC patients. The etiology of triggering osimertinib resistance is complex including EGFR-dependent and EGFR-independent pathways, and different therapeutic strategies for the NSCLC patients with osimertinib resistance have been developed. Herein, we comprehensively summarized the resistance mechanisms of osimertinib and discuss in detail the potential therapeutic strategies for EGFR-mutated NSCLC patients suffering osimertinib resistance for the sake of the improvement of survival and further achievement of precise medicine.
The impact of different targeted temperatures on out-of-hospital cardiac arrest outcomes in patients receiving extracorporeal membrane oxygenation: a nationwide cohort study
Authors: Watanabe Makoto , Matsuyama Tasuku , Miyamoto Yuki , Kitamura Tetsuhisa , Komukai Sho , Ohta Bon 
Published: December 2022

Abstract
Background
Targeted temperature management (TTM) is recommended in the management of out-of-hospital cardiac arrest (OHCA) when coma persists after the return of spontaneous circulation. In the setting of extracorporeal membrane oxygenation (ECMO) for OHCA patients, TTM is associated with good neurological outcomes and is recommended in the Extracorporeal Life Support Organization guidelines. However, the optimal targeted temperature for these patients has not yet been adequately investigated. This study aimed to compare the impact of different targeted temperatures on the outcomes in OHCA patients receiving ECMO.

Methods
This was a retrospective analysis of data from the Japanese Association for Acute Medicine (JAAM)-OHCA Registry, a multicentre nationwide prospective database in Japan in which 103 institutions providing emergency care participated. OHCA patients aged ≥ 18 years who required ECMO with TTM between June 2014 and December 2019 were included in our analysis. The primary outcome was 30-day survival with favourable neurological outcomes, defined as a Glasgow–Pittsburgh cerebral performance category score of 1 or 2. Patients were divided into two groups according to their targeted temperature: normothermic TTM (n-TTM) (35–36 °C) and hypothermic TTM (h-TTM) (32–34 °C). We compared the outcomes between the two targeted temperature groups using multivariable logistic regression and inverse probability weighting (IPW).

Results
A total of 890 adult OHCA patients who received ECMO and TTM were eligible for our analysis. Of these patients, 249 (28%) and 641 (72%) were treated with n-TTM and h-TTM, respectively. The proportions of patients with 30-day favourable neurological outcomes were 16.5% (41/249) and 15.9% (102/641), in the n-TTM and h-TTM groups, respectively. No difference in neurological outcomes was observed in the multiple regression analysis [adjusted odds ratio 0.91, 95% confidence interval (CI) 0.58–1.43], and the result was constant in the IPW (odds ratio 1.01, 95% CI 0.67–1.54).

Conclusion
No difference was observed between n-TTM and h-TTM in OHCA patients receiving TTM with ECMO. The current understanding that changes to the targeted temperature have little impact on the outcome of patients may remain true regardless of ECMO use.
What are the nursing competencies related to antimicrobial stewardship and how they have been assessed? Results from an integrative rapid review
Authors: Danielis Matteo , Regano Domenico , Castaldo Anna , Mongardi Maria , Buttiron Webber Tania 
Published: December 2022

AbstractBackgroundAntimicrobial resistance issues, and the consequent demand for antimicrobial stewardship (AMS) programs, need to be investigated urgently and clearly. Considering the large amount of time nurses spend at patients’ bedside, the aim of the present study was to examine recent literature on nursing competency in AMS.MethodsDrawing from Tricco and colleagues’ seven-stage process, a rapid review was performed. MEDLINE, CINAHL and EMBASE databased were searched from December 1st, 2019 until December 31st, 2021. Article screening and study selection were conducted independently by three reviewers. Data were analyzed narratively and categorized adopting an inductive thematic coding.ResultsSixteen studies met the inclusion criteria and were included. Publications were mainly authored in USA (n = 4), Australia and New Zealand (n = 4) and Asia (n = 4), followed by Europe (n = 2) and Africa (n = 2). Ten studies were quantitative in design, followed by qualitative (n = 4) and mixed-methods studies (n = 2). Nursing competency in AMS seems to be influenced by a two-dimensional model: on the one hand, internal factors which consisted in knowledge, attitudes and practices and, on the other hand, external aspects which are at environmental level in terms of structures and processes.ConclusionThis study provided a map of dimensions for researchers and practitioners to consider when planning clinical governance, educational activities, and research programs. Significant opportunities exist for nurses to contribute to practice, education, research, and policy efforts aimed at reducing antimicrobial resistance.
Doxycycline vs. macrolides in combination with a β-lactam antibiotic for the treatment of community-acquired pneumonia in inpatients
Authors: Aldhahri Raghad K. , Gabb Shahad G. , Shoaib Ohoud A. , Almadani Reem M. , Eljaaly Khalid , Thabit Abrar K. 
Published: December 2022

Abstract
Background
Hospitalized patients with non-severe community-acquired pneumonia (CAP) are treated with a β-lactam plus either a macrolide or doxycycline. Limited data exist on the effectiveness of the latter combination. Therefore, we aimed to compare the combination of doxycycline vs. macrolide when either is combined with a β-lactam from effectiveness and safety perspectives.

Methods
This was a retrospective cohort study in CAP inpatients between December 2013 and November 2020. Patients were divided into BL-D (β-lactam plus doxycycline) and BL-M (β-lactam plus a macrolide [azithromycin or clarithromycin]) groups. The primary endpoint was time to clinical stability. Secondary endpoints included length of stay (LOS) and in-hospital mortality.

Results
Of 197 patients included, 57 were in the BL-D arm and 140 were in the BL-M arm. Patients were similar at baseline, except for the presence of leukocytosis, risk factors for drug resistance, and duration of therapy (P < 0.05 for all comparisons). No difference in clinical cure rate was observed (94.7% vs. 91.4%; P = 0.43). Time to clinical stability and LOS were similar in both groups at 4 (P = 0.82) and 7 days (P = 0.62), respectively. While only three patients died, only one (from the BL-M group) was due to sepsis. Liver enzymes elevation was more prominent in the BL-M group (21.4% vs. 5.3%; P = 0.01). A subgroup analysis showed shorter time to clinical stability with clarithromycin but higher cure rates with azithromycin.

Conclusions
Data on doxycycline use with a β-lactam are scarce. Our study showed that such regimen was comparable in effectiveness to regimens involving macrolides with a better safety profile.
Comprehensive characterization of putative genetic influences on plasma metabolome in a pediatric cohort
Authors: Lee In-Hee , Smith Matthew Ryan , Yazdani Azam , Sandhu Sumiti , Walker Douglas I. , Mandl Kenneth D. , Jones Dean P. , Kong Sek Won 
Published: December 2022

Abstract
Background
The human exposome is composed of diverse metabolites and small chemical compounds originated from endogenous and exogenous sources, respectively. Genetic and environmental factors influence metabolite levels, while the extent of genetic contributions across metabolic pathways is not yet known. Untargeted profiling of human metabolome using high-resolution mass spectrometry (HRMS) combined with genome-wide genotyping allows comprehensive identification of genetically influenced metabolites. As such previous studies of adults discovered and replicated genotype–metabotype associations. However, these associations have not been characterized in children.

Results
We conducted the largest genome by metabolome-wide association study to date of children (N = 441) using 619,688 common genetic variants and 14,342 features measured by HRMS. Narrow-sense heritability (h2) estimates of plasma metabolite concentrations using genomic relatedness matrix restricted maximum likelihood (GREML) method showed a bimodal distribution with high h2 (> 0.8) for 15.9% of features and low h2 (< 0.2) for most of features (62.0%). The features with high h2 were enriched for amino acid and nucleic acid metabolism, while carbohydrate and lipid concentrations showed low h2. For each feature, a metabolite quantitative trait loci (mQTL) analysis was performed to identify genetic variants that were potentially associated with plasma levels. Fifty-four associations among 29 features and 43 genetic variants were identified at a genome-wide significance threshold p < 3.5 × 10–12 (= 5 × 10–8/14,342 features). Previously reported associations such as UGT1A1 and bilirubin; PYROXD2 and methyl lysine; and ACADS and butyrylcarnitine were successfully replicated in our pediatric cohort. We found potential candidates for novel associations including CSMD1 and a monostearyl alcohol triglyceride (m/z 781.7483, retention time (RT) 89.3 s); CALN1 and Tridecanol (m/z 283.2741, RT 27.6). A gene-level enrichment analysis using MAGMA revealed highly interconnected modules for dADP biosynthesis, sterol synthesis, and long-chain fatty acid transport in the gene-feature network.

Conclusion
Comprehensive profiling of plasma metabolome across age groups combined with genome-wide genotyping revealed a wide range of genetic influence on diverse chemical species and metabolic pathways. The developmental trajectory of a biological system is shaped by gene–environment interaction especially in early life. Therefore, continuous efforts on generating metabolomics data in diverse human tissue types across age groups are required to understand gene–environment interaction toward healthy aging trajectories.
Establishment of an indicator framework for global One Health Intrinsic Drivers index based on the grounded theory and fuzzy analytical hierarchy-entropy weight method
Authors: Feng Jiaxin , Guo Zhaoyu , Ai Lin , Liu Jingshu , Zhang Xiaoxi , Cao Chunli , Xu Jing , Xia Shang , Zhou Xiao-Nong , Chen Jin , Li Shizhu 
Published: December 2022

Abstract
Background
One Health has become a global consensus to deal with complex health problems. However, the progress of One Health implementation in many countries is still relatively slow, and there is a lack of systematic evaluation index. The purpose of this study was to establish an indicator framework for global One Health Intrinsic Drivers index (GOH-IDI) to evaluate human, animal and environmental health development process globally.

Method
First, 82 studies were deeply analyzed by a grounded theory (GT) method, including open coding, axial coding, and selective coding, to establish a three-level indicator framework, which was composed of three selective codes, 19 axial codes, and 79 open codes. Then, through semi-structured interviews with 28 health-related experts, the indicators were further integrated and simplified according to the inclusion criteria of the indicators. Finally, the fuzzy analytical hierarchy process combined with the entropy weight method was used to assign weights to the indicators, thus, forming the evaluation indicator framework of human, animal and environmental health development process.

Results
An indicator framework for GOH-IDI was formed consisting of three selective codes, 15 axial codes and 61 open codes. There were six axial codes for “Human Health”, of which “Infectious Diseases” had the highest weight (19.76%) and “Injuries and Violence” had the lowest weight (11.72%). There were four axial codes for “Animal Health”, of which “Animal Epidemic Disease” had the highest weight (39.28%) and “Animal Nutritional Status” had the lowest weight (11.59%). Five axial codes were set under “Environmental Health”, among which, “Air Quality and Climate Change” had the highest weight (22.63%) and “Hazardous Chemicals” had the lowest weight (17.82%).

Conclusions
An indicator framework for GOH-IDI was established in this study. The framework were universal, balanced, and scientific, which hopefully to be a tool for evaluation of the joint development of human, animal and environmental health in different regions globally.
The origins, characteristics and trends of neo-nationalism in the 21st century
Authors: Zhou Shaoqing 
Published: December 2022

AbstractThe rise of neo-nationalism has been an important political phenomenon since the 21st century. Neo-nationalism is not a single form of nationalism. It is not only a generalization of a specific type of nationalism at present, but also a description of a series of new nationalism phenomena. From the point of what it may include, it has at least four forms: far-right nationalism, evangelical nationalism, separatist nationalism, and (the third world) religious nationalism. Compared with traditional nationalism, neo-nationalism has undergone major changes in terms of guiding ideology or values behind, epochal character, propulsion mechanism, function, propagation mode, influence, and field of occurrence. At the same time, neo-nationalism is also a kind of high-intensity identity politics with a sort of quasi-fundamentalist characteristics. It discards the core value principles of traditional nationalism and the basic etiquette of polite society. Some dangerous and even crazy essential factors of nationalism have been developed to extremes in the new era. This means that its destructiveness to specific countries and societies is far greater than that caused by the reactive identity politics of minorities. From the perspective of trends in development, while the neo-nationalism shows the general characteristics of co-advance and retreat in the general trend, its four specific forms also show certain differences in the development direction. With the further setback of the globalization process, neo-nationalism will have a significant impact on the security of relevant countries, regions and even the world.
Gender effects of the COVID-19 pandemic in the Swiss labor market
Authors: Dubois Corinne , Lambertini Luisa , Wu Yu 
Published: December 2022

AbstractWe study the impact of the pandemic on gender gaps in labor market outcomes in Switzerland. Using the Swiss Labor Force Survey data, we document a significant increase in the gender gap in labor market participation. We find no evidence of a worsening of the unemployment gender gap during the pandemic, but we find that women were more likely to uptake short-time work (STW). Unlike the USA, the presence of children in the household did not worsen labor gender gaps. Sector and occupation, however, play an important role in explaining gender gaps. In particular, we document substantial heterogeneity in the effect of the pandemic on participation, STW, hours worked, and wage outcomes depending on the availability of telework in the respondent’s occupation.
Beyond nutrition: social–cultural values of meat and meat products among the Borana people of Northern Kenya
Authors: Dabasso Buke G. , Makokha Anselimo O. , Onyango Arnold N. , Mathara Julius M. 
Published: December 2022

AbstractTo most indigenous communities, livestock plays important socio-cultural roles in addition to sustenance. Like many other communities in the world, the Borana people regard livestock and livestock products not only as nourishment but as an integral part of their cultural identity and social construct. The Borana are Cushitic-speaking people who reside in northern Kenya and southern Ethiopia and practise pastoralism as the primary way of livelihood. Livestock is reared by Borana people to obtain meat, milk and other by-products further to socio-cultural roles that were important for communal prosperity and resilience. The aim of this paper was therefore, to describe the various role of cattle and its significance to Borana people. For data collection, qualitative methods such as key informant interviews and focus group discussions were used. The interviews were audio recorded, transcribed and analysed. The results showed that cattle and particularly bulls were slaughtered for meat consumption, rituals and high-value ceremonial purposes. Moreover, as a desired form of wealth, cattle provide numerous resources to the owners and the prestige associated with herd of cattle accelerates social status and identity among the Borana community. Thus, according to participants’ discussions and views, cattle are highly symbolic and have cultural meaning not only as the primary source of food but also in shaping social–cultural values embedded in their social structure. The various role of cattle and its products had significant implications on food security; the traditional practice of livestock wealth sharing shielded the Borana community in times of need and the practice of commensality led to greater social bonds. However, the changing socio-cultural environment caused by recurrent droughts has affected the traditional coping mechanism and led to alternative forms of livelihood.
A sporadic case of holocord tuberculous transverse myelitis with arachnoiditis
Authors: Ranjan Sukrati , Dev Rahul , Keisham Miranda Devi 
Published: December 2022

Abstract
Background
Tubercular infection of the brain and spine is relatively common in endemic regions of the world. Central nervous system tuberculosis can have varied manifestations. The familiar imaging findings are hydrocephalus, ring-enhancing tuberculomas, and meningeal enhancement, having a preference for basal regions. Myelitis is the most common imaging manifestation of spine, with holocord involvement being a rare presentation, as seen in our case.

Case presentation
We present a case of a pediatric patient undergoing treatment for a tubercular infection of the brain. The patient developed acute onset quadriparesis, manifesting as holocord transverse myelitis on imaging. The imaging findings in the brain manifested as basal meningeal enhancement and non-communicating hydrocephalus, managed by shunt placement. As of the latest, the patient is on follow-up and has a stable disease course. Clinical and laboratory investigations excluded other infectious and non-infectious causes of transverse myelitis, including neuromyelitis optica spectrum disorders.

Conclusions
Longitudinally extensive transverse myelitis is a rare complication of tubercular myelitis seen as a long-segment signal abnormality with swelling of the cord and corresponding post-contrast enhancement. Involvement of the entire cord is rare, with a handful of cases reported in the literature.
Evaluation of correlation between antral follicle diameters with Follicular Output Rate (FORT) in women under controlled ovarian hyperstimulation for assisted reproductive techniques
Authors: Mardanian Farahnaz , Dehghani-Mohammadabadi Reihaneh , Tehrani Hatav Ghasemi , Naghshineh Elham , Mehrabian Ferdous 
Published: December 2022

Abstract
Background
This study aimed to determine the association of diametrical antral follicles with the ovarian response by Follicular Output Rate (FORT) ratio in 100 females undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). This study selected 100 women undergoing controlled ovarian hyperstimulation (COH). The number of antral follicles (diameter of 3–10 mm) was calculated with two-dimensional vaginal sonography on days 1–3 of the cycle. Then, on a triggering day with human chorionic gonadotropin (HCG), the number of follicles (with a diameter of 16–22 mm) and the ratio of FORT were determined. The correlation among FORT with age, antral follicle count (AFC), AFC ≤ 5, AFC > 5, number of preovulatory follicles (16–20 mm), number of metaphase II (MII) oocytes, body mass index (BMI), infertility period, and anti-Mullerian hormone (AMH) was assessed.

Results
There was a significant correlation between FORT and total AFC, AFC > 5, number of preovulatory follicles (16–20 mm), and number of MII oocytes retrieved. There is no significant relationship between FORT and examined two variables (AMH and AFC ≤ 5). Multiple linear regression analysis showed no significant relationship between FORT and examined two variables (AMH and AFC > 5). There was a significant correlation between MII oocytes retrieved and age, total AFC, AFC ≤ 5, AFC > 5, number of preovulatory follicles (16–20 mm), and AMH. A significant positive relationship existed between MII oocytes retrieved and examined two variables (AFC ≤ 5 and AFC > 5).

Conclusion
There was not much difference in the correlation between the AFC ≤ 5 and AFC > 5, and both positively correlated with the number of MII oocytes retrieved.