bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of common maintenance drugs on the risk and severity of COVID-19 in elderly patients
Authors: Fung Kin Wah , Baik Seo H. , Baye Fitsum , Zheng Zhaonian , Huser Vojtech , McDonald Clement J. 
Published: April 2022

Background
Maintenance drugs are used to treat chronic conditions. Several classes of maintenance drugs have attracted attention because of their potential to affect susceptibility to and severity of COVID-19.

Methods
Using claims data on 20% random sample of Part D Medicare enrollees from April to December 2020, we identified patients diagnosed with COVID-19. Using a nested case-control design, non-COVID-19 controls were identified by 1:5 matching on age, race, sex, dual-eligibility status, and geographical region. We identified usage of angiotensin-converting enzyme inhibitors (ACEI), angiotensin-receptor blockers (ARB), statins, warfarin, direct factor Xa inhibitors, P2Y12 inhibitors, famotidine and hydroxychloroquine based on Medicare prescription claims data. Using extended Cox regression models with time-varying propensity score adjustment we examined the independent effect of each study drug on contracting COVID-19. For severity of COVID-19, we performed extended Cox regressions on all COVID-19 patients, using COVID-19-related hospitalization and all-cause mortality as outcomes. Covariates included gender, age, race, geographic region, low-income indicator, and co-morbidities. To compensate for indication bias related to the use of hydroxychloroquine for the prophylaxis or treatment of COVID-19, we censored patients who only started on hydroxychloroquine in 2020.

Results
Up to December 2020, our sample contained 374,229 Medicare patients over 65 who were diagnosed with COVID-19. Among the COVID-19 patients, 278,912 (74.6%) were on at least one study drug. The three most common study drugs among COVID-19 patients were statins 187,374 (50.1%), ACEI 97,843 (26.2%) and ARB 83,290 (22.3%). For all three outcomes (diagnosis, hospitalization and death), current users of ACEI, ARB, statins, warfarin, direct factor Xa inhibitors and P2Y12 inhibitors were associated with reduced risks, compared to never users. Famotidine did not show consistent significant effects. Hydroxychloroquine did not show significant effects after censoring of recent starters.

Conclusion
Maintenance use of ACEI, ARB, warfarin, statins, direct factor Xa inhibitors and P2Y12 inhibitors was associated with reduction in risk of acquiring COVID-19 and dying from it.
Automatic classification of lymphoma lesions in FDG-PET–Differentiation between tumor and non-tumor uptake
Authors: Georgi Thomas W , Zieschank Axel , Kornrumpf Kevin , Kurch Lars , Sabri Osama , Körholz Dieter , Mauz-Körholz Christine , Kluge Regine , Posch Stefan 
Published: April 2022

Introduction
The automatic classification of lymphoma lesions in PET is a main topic of ongoing research. An automatic algorithm would enable the swift evaluation of PET parameters, like texture and heterogeneity markers, concerning their prognostic value for patients outcome in large datasets. Moreover, the determination of the metabolic tumor volume would be facilitated. The aim of our study was the development and evaluation of an automatic algorithm for segmentation and classification of lymphoma lesions in PET.

Methods
Pre-treatment PET scans from 60 Hodgkin lymphoma patients from the EuroNet-PHL-C1 trial were evaluated. A watershed algorithm was used for segmentation. For standardization of the scan length, an automatic cropping algorithm was developed. All segmented volumes were manually classified into one of 14 categories. The random forest method and a nested cross-validation was used for automatic classification and evaluation.

Results
Overall, 853 volumes were segmented and classified. 203/246 tumor lesions and 554/607 non-tumor volumes were classified correctly by the automatic algorithm, corresponding to a sensitivity, a specificity, a positive and a negative predictive value of 83%, 91%, 79% and 93%. In 44/60 (73%) patients, all tumor lesions were correctly classified. In ten out of the 16 patients with misclassified tumor lesions, only one false-negative tumor lesion occurred. The automatic classification of focal gastrointestinal uptake, brown fat tissue and composed volumes consisting of more than one tissue was challenging.

Conclusion
Our algorithm, trained on a small number of patients and on PET information only, showed a good performance and is suitable for automatic lymphoma classification.
Avengers Assemble! Critical Perspectives on the Marvel Cinematic Universe, Terence McSweeney (2018)
Authors: Goodrum Michael 
Published: April 2022

Review of: Avengers Assemble! Critical Perspectives on the Marvel Cinematic Universe, Terence Mcsweeney (2018)
New York: Wallflower Press, 310 pp.,
ISBN 978-0-23118-625-4, h/bk, £81, p/bk, £25
Abnormal Perception of Urge to Defecate: An Important Pathophysiological Mechanism in Women With Chronic Constipation
Authors: Vollebregt Paul F. , Wiklendt Lukasz , Burgell Rebecca E. , Chaichanavichkij Pam , Dinning Phil G. , Knowles Charles H. , Scott S. Mark 
Published: April 2022

INTRODUCTION:
Although the association of absent or attenuated “call to stool” with constipation is well-recognized, no studies have systematically evaluated the perception of urge to defecate in a well-defined cohort of patients with chronic constipation (CC).

METHODS:
A prospective study of 43 healthy adult women and 140 consecutive adult women attending a tertiary center for investigation of CC. All participants completed a 5-day viscerosensory questionnaire, and all women with CC also underwent anorectal physiologic investigations. Normal urge perception and abnormal urge perception were defined using a Naive Bayes model trained in healthy women (95% having normal urge).

RESULTS:
In total, 181 toilet visits in healthy women and 595 in women with CC were analyzed. Abnormal urge perception occurred in 70 (50.0%) women with CC. In this group, the urge to defecate was more often experienced as abdominal sensation (69.3% vs 41.4%; P < 0.0001), and the viscerosensory referral area was 81% larger (median pixels anterior: 1,849 vs 1,022; P < 0.0001) compared to women with CC and normal urge perception. Abnormal (vs normal) urge in women with CC was associated with more severe constipation (Cleveland Clinic constipation score: 19 vs 15 P < 0.0001), irritable bowel syndrome (45.7% vs 22.9% P < 0.0001), and a functional evacuation disorder on defecography (31.3% vs 14.3% P = 0.023). A distinct pattern of abnormal urge was found in women with CC and rectal hyposensitivity.

DISCUSSION:
Abnormal urge perception was observed in 50% of women with CC and was frequently described as abdominal sensation, supporting the concept that sensory dysfunction makes an important contribution to the pathophysiology of constipation.
Comparative Effectiveness of Biologics for Endoscopic Healing of the Ileum and Colon in Crohn's Disease
Authors: Narula Neeraj , Wong Emily C.L. , Dulai Parambir S. , Marshall John K. , Jairath Vipul , Reinisch Walter 
Published: April 2022

INTRODUCTION:
We compared the efficacy of adalimumab, infliximab, ustekinumab, and vedolizumab on the ability to achieve endoscopic healing (EH) after 1 year of therapy in moderate-severe Crohn's disease (CD).

METHODS:
This was a pooled analysis of patient-level data from 299 patients with CD from 4 clinical trials. Proportions of patients treated with each biologic were compared for achieving 1-year complete EH (Simple Endoscopic Score for CD [SES-CD] <3) and ileal and colonic EH separately (SES-CD = 0). Multivariate logistic regression was used to model the relationship between biologics and 1-year outcomes and adjusted for disease duration, concomitant corticosteroid use, and prior antitumor necrosis factor failure.

RESULTS:
Compared with vedolizumab (4/56 [7.1%]), adalimumab (17/61 [27.9%], adjusted odds ratio [OR]: 5.79, 95% confidence interval [CI]: 1.77–18.95, P = 0.004) and infliximab (39/141 [27.7%], aOR: 4.59, 95% CI: 1.48–14.22, P = 0.008) had superior rates of 1-year EH. No significant difference was observed between vedolizumab and ustekinumab. Similar results were observed among biologic-naive patients. Among patients with baseline ileal SES-CD ≥3, no significant differences were observed between biologics for 1-year ileal EH. However, for large (>0.5 cm) ileal ulcers, infliximab (20/49 [40.8%]) had superior rates of no ileal ulcers compared with vedolizumab (2/23 [8.7%], aOR: 5.39, 95% CI: 1.03–28.05, P = 0.045). No other differences were observed. For colonic disease, compared with ustekinumab (9/31 [29.0%]), adalimumab (30/48 [62.5%], aOR: 3.97, 95% CI: 1.45–10.90, P = 0.007) had superior rates of 1-year EH in the colon, with similar trends observed for infliximab (55/105 [52.4%], aOR: 2.08, 95% CI: 0.82–5.27, P = 0.121). No other differences were observed.

DISCUSSION:
In this post hoc analysis, TNF-α antagonists were overall superior to vedolizumab and ustekinumab for achieving 1-year EH in moderate-severe CD patients.
Changesin the midst ofa construction network: a diachronic construction grammar approach to complex prepositions denoting internal location
Authors: Desagulier Guillaume 
Published: April 2022

AbstractLinguists have debated whether complex prepositions deserve a constituent status, but none have proposed a dynamic model that can both predict what construal a given pattern imposes and account for the emergence of non-spatial readings. This paper reframes the debate on constituency as a justification of the constructional status of complex prepositional patterns from a historical perspective. It focuses on thePrep NPILof NPlmconstruction, which denotes a relation of internal location between a located entity (a trajector) and a reference entity (a landmark). Four subschemas of the Internal Location construction are examined:middlecxn(in the middle of),centercxn(in/at the center of),heartcxn(in/at the heart of), andmidstcxn(in the midst of). All occurrences are extracted from the COHA, along with their co-occurring landmark NPs. Using vocabulary growth curves, all patterns are shown to be productive over the whole period covered by the corpus, although at different levels. Usingword2vec, a semantic vector space with the landmark collocates of each pattern is made. Curves indexed on association scores are plotted to see how densely semantic areas have been populated across four consecutive periods: 1810s–1860s, 1870s–1910s, 1920s–1970s, and 1980s–2000s. Two divisions of labor have emerged.midstcxnandheartcxnare in complementary distribution and operate mostly at the level of abstract locations whereasmiddlecxnandcentercxnare in parallel distribution and operate at the level of concrete locations.
Numerical prediction of cavitation phenomena on marine vessel: Effect of the water environment profile on the propulsion performance
Authors: Yusvika Muhammad , Fajri Aprianur , Tuswan Tuswan , Prabowo Aditya Rio , Hadi Syamsul , Yaningsih Indri , Muttaqie Teguh , Laksono Fajar Budi 
Published: April 2022

AbstractEnergy-saving and emission reduction are crucial since shipping activity due to the global maritime trade has increased exponentially. Several agreements have been engaged to optimize ship energy efficiency composed of ship design and shipping operation planning. However, most up-to-date studies focused on speed and route optimization. The interaction analysis between speed and route efficiency below varied environmental conditions is limited. To attain energy and cost efficiency, a study of cavitation on the propeller that considers the ocean environmental condition will be discussed in this work. Although researchers have previously observed cavitation phenomena, the predictability of simulations is not yet such that problems can be eliminated. Since the multiphase flow of water and vapor is sensitive to environmental conditions, it leads to varying observation accuracy. Thus, the current paper proposes a new performance indicator of the ship propeller under cavitation predicted by computational fluid dynamics (CFD). CFD-based simulation to observe the propeller cavitation was used to model the Zwart cavitation and Kunz cavitation models under two turbulence models ofK−εat different flow conditions and operating environments. Initial validation tests between experimental and numerical simulation show good agreement with a mean error of 4.7% in the Zwart model and 3.7% in the Kunz model, where thek−εturbulence model provides an almost higher relative error. It is revealed from the result that the increase in temperature causes the rise in the cavitation problem. It is revealed from the result that the increase of temperature causes the increase in cavitation problem.
A comprehensive evaluation method for topographic correction model of remote sensing image based on entropy weight method
Authors: Yao Mingkun , Huang Jiejun , Zhang Ming , Zhou Han , Kuang Lulu , Ye Fawang 
Published: April 2022

AbstractThe effect of topographic correction (TOC) has a profound influence on the quantitative application of remote sensing image. With regard to the invalid evaluation of the TOC model with such a single topographic correction assessment (TCA) method, we have selected five TCA indexes from five different perspectives: the difference in mean radiance radiometry between sunlit and shaded slopes, the cosine empirical relationship, stability, heterogeneity, and outlier ratio. The entropy weight method was used to assign weight to each TCA indexes, and the comprehensive evaluation value (CEV) of TOC for each band of remote sensing image was obtained by weighted superposition. After that, the weight of each band of the remote sensing image is determined by the entropy weight method, and the CEV of the TOC of the remote sensing image is obtained by weighting and superposition, so as to realize the effect evaluation of the six TOC models of C, SCS + C, VECA, Teillet, Minnaert, and Minnaert + SCS. The results indicate that the proposed method can effectively evaluate the correction effect of the TOC model. Results indicate that the SCS + C model has the best correction effect, while the Minnaert model performs the worst. The results generated from the Minnaert + SCS, Teillet, and Minnaert models typically show inferior quality. The SCS + C, VECA, and C models are better suited for generating images with high spectral fidelity, and these three correction models are recommended for TOCs over mountainous areas.
Learning on the periphery: a modified Delphi study of a nursing student communities of practice model
Authors: Terry Daniel , Peck Blake , Perkins Alicia J. , Burgener Wendy 
Published: April 2022

AbstractObjectivesTo develop a contemporary student placement model to address current placement challenges, impact student learning, and alleviate supervisor burden.MethodsA modified Delphi technique was used to seek opinions, insights, and creative solutions.ResultsA draft Communities of Practice placement model, based on a systematic literature review, was introduced to a heterogenous expert panel (n=12). A contemporary placement model was developed and refined via video conference and email over three rounds.ConclusionsDespite initial reluctance concerning a new model, participants became conversant with the concept of peer-to-peer learning, where incidental, albeit essential, learning and support occurs between students, which also supports supervising staff. Greater flexibly and student screening were also incorporated to enable greater learning, confidence building, and reflection. The model’s success is contingent upon students working within their scope of practice and provides a contemporary approach to best responds to student, education provider, and health service needs.
Review on nutraceuticals: phase transition from preventive to protective care
Authors: Jain Nishakumari , Radhakrishnan Arun , Kuppusamy Gowthamarajan 
Published: April 2022

Abstract
Nutraceuticals are essential for healthcare which is an alternative medicine that has gained popularity in recent years. Nutraceuticals consist of nutrients, herbals, and dietary supplements, which make them useful in preserving and promoting health, fighting illness, and improving overall quality of life. Its success or failure will be determined by its rapid expansion, research advances, lack of standards, marketing enthusiasm, quality assurance, and regulations. Nutraceuticals have been used in different regions under different names/categories. however, globally there are no stringent pharmaceutical standards for nutraceutical health products till date, but slowly regulators are paying attention on it. Nutraceuticals can be broadly classified according to it clinical significance, source and therapeutic effects. Nutraceuticals and functional foods have grown to be a multibillion-dollar business worldwide in recent years and personalization is the emerging approach to deliver the best therapeutic effect in future. This review carries extensive information about nutraceutical history, classification, regulatory aspects and industrial perspective.
Identity and the choice of writing system in the Achaemenid world
Authors: Benvenuto Maria Carmela 
Published: April 2022

Abstract
The paper investigates the choice of writing system as the visual representation of identity in a specific multilingual and multi-ethnic context of antiquity, namely, the Achaemenid Empire. In particular, the discussion focuses on the linguistic and socio-cultural environment in Lydia and Hellespontine Phrygia, the western satrapies of the Persian Empire, where various languages and writing systems were available. Through the cases study analyzed here it has been possible to detect the symbolic status of a language – as well as that of its writing system – in the expression of ethnic identity at the local community level. In the case of Lydia, the analysis of the seals inscriptions provides evidence of identity negotiation from individuals of the local elite who were engaging with Persian power. The bullae from Daskyleion reflect a different linguistic practice in the context of power relations. Interestingly, even though the central imperial authority did not take advantage of any specific language use, including Aramaic, as a means to impose power, the presence of seals in Aramaic in the Daskyleion archive seems to suggest that it had status as an international prestige language, imbuing the inscriber of any ethnicity with the might of imperial power.
Urban road traffic noise monitoring, mapping, modelling, and mitigation: A thematic review
Authors: Ranpise Ramesh B. , Tandel Bhaven N. 
Published: April 2022

Abstract
This article analyses the most recent studies on urban traffic noise. About 67 relevant articles on urban road traffic noise and its mitigation strategies were preferred for a critical review. Only 5.97% of items describe how to monitor and record the noise measurement for urban roads, while 7.46% of articles enumerated urban traffic noise pollution exposure. 29.85% of articles proposed a model to evaluate noise reduction effects and predict the noise level. Also, many articles reported noise map generation and its analysis. 56.71% of articles described the noise mitigation strategies in detail, concerning noise control by green vegetation, land use planning, low noise tire and pavement material, noise reduction through façade shielding. Noise pollution standards are being breached in all areas. There is a need for the proper implementation of rules and regulations. Therefore, noise mitigation strategies such as designing noise barriers and other noise control materials are needed. Finally, it is summarized that economic and low-cost optimized noise pollution mitigation strategies like ingeniously made noise barriers, vegetation and landscaping are need of the hour for urban areas of developing countries.
The Civic Engagement and Social Integration of Refugees in Germany
Authors: Barreto César , Berbée Paul , Gallegos Torres Katia , Lange Martin , Sommerfeld Katrin 
Published: April 2022

Abstract
Civil society has played an important role in meeting the challenges of refugee migration in recent years. This commentary documents the importance of civic engagement for the integration of refugees by linking individual survey data on refugees to a regional measure of civic engagement in Germany. Using the density of newly established civic associations at the county level as a measure of civic engagement, we exploit regional differences in civic engagement in order to estimate its association with refugee integration outcomes. We find that in regions with particularly high levels of civic engagement, refugees have significantly more frequent contact to Germans, higher life satisfaction, and better German language skills. This correlation is robust to regional contextual factors such as the local population structure, economic strength, and the state of the labor market. In terms of language acquisition, women and refugees with a low level of education benefit the most from high civic engagement. Moreover, refugees with university degrees find significantly better-paying jobs in areas with higher civic engagement. However, no direct correlation could be established between civic engagement and the likelihood that refugees are employed. Nonetheless, the results suggest that support from civil society translates into improved access to government benefits. Our findings highlight that local civic engagement is an important complement to public assistance services and policy makers should give a high priority to partnering with the civil society to improve refugees’ integration outcomes.
A systematic review on photo-Fenton process as an efficient advanced oxidation for degradation of amoxicillin in aqueous environments
Authors: Pirsaheb Meghdad , Hossaini Hiwa , Raad Nazanin Kiani , Kianpour Sara , Hossini Hooshyar 
Published: April 2022

Abstract
Amoxicillin (AMX) is one of the antibiotics in the penicillin category that is used in various fields. Considering the harmful effects of its remains, it is necessary to survey the ways to remove this compound. Advanced oxidation process (AOPs), specially photo-Fenton has been used for the removal of AMX. This study has been conducted based on PubMed, Google Scholar, DOAJ, Web of Science, and Scopus databases during the years 2008–2019. Some factors such as the aquatic solution, light source characteristics, iron, and H2O2 concentration, AMX degradation percentage, removal of total organic carbon percentage, and AMX concentration have been surveyed to optimize the process. Studies showed that the photo-Fenton process is highly dependent on pH, and in most studies, the highest efficiency has been observed in acidic pH values. Using a more energy light source can be effective in reducing the use of catalysts and oxidizers. The combined methods of AOPs such as photo-Fenton, electro-Fenton, and photo-electro-Fenton have higher efficiency in increasing mineralization than the photon process. The use of synthetic wastewater has a higher efficiency in the degradation of AMX than in real wastewater in the photo-Fenton process, which can be due to the absence of the interfering agents in synthetic environments.