bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Study of the Efficacy of Intralesional 5 Fluorouracil vs Combination of 5 Fluorouracil with Triamcinolone Acetonide in Keloids
Authors: Monteiro Rochelle C , Bhat M Ramesh , Martis Jacintha , Kamath H Ganesh 
Published: September 2022

Context:
Keloids are defined as scars that invade the adjacent tissues and rarely regress. In recent years, antimitotic drugs have been used in the management of keloids with promising results. This study highlights the effectiveness of 5-fluorouracil (5-FU) in keloids.

Aims:
To study the efficacy of intralesional 5-FU in keloids as a solo agent and in combination with triamcinolone acetonide and to study the side effects of both the drugs.

Methods and Materials:
A total of 30 patients with keloids were randomly allocated into two groups. Group A received 50 mg/mL of 5-FU intralesionally. Group B patients received a combination of 40 mg/mL of intralesional triamcinolone acetonide and 50 mg/mL of 5-FU. The patients were observed for immediate and delayed complications and the treatment was continued for a total of 3 months.

Statistical Analysis Used:
ANOVA, Mann–Whitney test, Fisher's test, Chi-square test.

Results:
The patients in both groups showed a significant reduction in the size and thickness of the lesions. The reduction in the length of keloid was highly significant in both the groups but in comparison, there was no statistically significant difference in the reduction of lesions among both the groups. Hence, both modalities of treatment can be claimed to be equally efficacious. The therapeutic response was good to excellent in most patients with only one patient opting out of the therapy in the 5-FU group due to the inability to tolerate the pain. The common side effects noted were pain, itching, ulceration, burning sensation, and bulla formation.

Conclusions:
5-FU, both as a single agent or in combination with steroids is equally efficacious in reducing the keloid size. The side effects are lesser with the combination group.
A Clinico-Demographic Profile and Sexual Behaviour Pattern in Attendees of Designated STI/RTI Clinic Having Sexually Transmitted Infections with Special Reference to HIV Seropositivity
Authors: Datta Jayanti , Patra Aparesh C. , Ghosh Arghyaprasun , Roy Sudipta , Das Nilay K. 
Published: September 2022

Introduction:
The dynamics of sexually transmitted infections (STIs) are influenced by sexual behaviour (age of first sexual exposure, number of sexual partner/s, sexual orientation, mode of intercourse, addiction, occupation, correct and consistent use of condom). The presence of the human immunodeficiency virus (HIV) influences the clinical pattern of STIs and the course of disease too.

Objective:
Our study was conducted to find the prevalence of STIs among attendees of a designated STI/RTI clinic (DSRC) with the description of clinico-demographic profile and sexual behaviour and association of HIV seropositivity with STIs.

Methods:
Ours was an institution-based cross-sectional study conducted at DSRC after obtaining ethics committee approval and consent from patients. Clinical diagnosis, demographic profile and sexual history were obtained after maintaining audio-visual privacy.

Statistical Analysis:
Medcalc, version 10.2 was used.

Results:
Among 167 patients attending DSRC during the study period, 76 having sexual dysfunctions were excluded. The major STIs diagnosed were primary syphilis (6.59%), secondary syphilis (2.2%), herpes genitalis (42.86%), condyloma acuminata (26.37%), molluscum contagiosum (5.49%), genital candidiasis (7.69%), bowenoid papulosis (3.3%), genital scabies (4.4%) and chancroid (1.1%). Sexual orientations were heterosexual (64.83%), lesbian (1.1%), gay (12.1%), bisexual (17.58%) and with an animal partner (4.4%). Among the total study population, 8.8% was rapid plasma reagin (RPR) reactive and 12.1% was Integrated Counselling and Testing Centre (ICTC) reactive. Among the total patients who used condoms (n = 49), only 15 (16.4% of total participants) used condoms correctly and consistently. Peno-vaginal mode of intercourse (n = 78) was found to be most common followed by oro-insertive (n = 42), oro-receptive (n = 34), ano-insertive (n = 24), ano-receptive (n = 17) and digital insertion (n = 20).

Conclusion:
Sexual behaviour influences the disease outcome in patients with reproductive tract infection (RTI)/STI.
The Clinical Phenotypes of Cutaneous Leishmaniasis in Central and Southwest Regions of Yemen
Authors: Muthanna Ahlam M. , Malhomme Helena D. , Schwartz Robert A. , Al-Qubati Yasin A. 
Published: September 2022

Background:
Cutaneous leishmaniasis (CL) is endemic in Yemen. CL displays a spectrum of typical and atypical morphologies yet understudied in the central and southwest regions of Yemen.

Aims and Objectives:
To identify the typical and atypical clinical phenotypes of CL in the central and southwest regions of Yemen.

Materials and Methods:
A survey of 145 patients who visited Prof. Al-Qubati Clinic in Taiz between 2010 and 2015, was conducted.

Results:
Children and residents of the rural areas were at high risk of exposure to the insect vector. The typical phenotype was single (67%), facial (58%) and ulcerated nodule (35%). Other usual phenotypes were small ulcers (21.4%) and non-ulcerative papules and nodules (21%). Unusual phenotypes constituted 12% of the cohort and included psoriasiform, eczematous, erysipeloid, lupoid, verrucous, large ulcerative, leishmania recidivens, satellite, granulomatous infiltrative and hyperkeratotic plaques. Mucous membrane involvement was evident in 10.6% and was also polymorphic.

Conclusion:
CL has many morphologic patterns in central and southwest regions of Yemen, some are clinically deceptive.
Assessment of Mucosa-Associated Epithelial Chemokine, Thymus-Expressed Chemokine, Periostin and Zonulin Levels in Infants With Atopic Dermatitis
Authors: Koksal Burcu Tahire , Zengin Hatice Yagmur , Ozbek Ozlem Yılmaz 
Published: September 2022

Background:
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Skin and gut are the organs that first encounter antigens and environmental triggers. The mechanisms behind the relation between skin and gut immune responses in AD have not been identified yet.

Aims and Objectives:
To investigate mucosa-associated epithelial chemokine (MEC/CCL28), thymus-expressed chemokine (TECK/CCL25), periostin and zonulin levels in infants with AD.

Materials and Methods:
Children under one year old participated in the study. We used a propensity matching score. We included 39 infants who had active AD lesions at the time of evaluation. Serum MEC/CCL28, TECK/CCL25, periostin and zonulin levels were measured.

Results:
We examined age and sex matched 39 infants with AD and 39 healthy infants. Median value of zonulin was lower in infants with AD [49.2 (27.1–71.8) ng/mL] compared to healthy controls [58.5 (27.3–80.8) ng/mL] (P < 0.001). Infants with zonulin levels ≤55.15 ng/mL had 11.64 times more risk of developing AD than the infants with zonulin levels >55.15 ng/mL. Infants whose MEC/CCL28 levels were ≥8.3 ng/mL had 5.83 times more risk of developing AD than the infants with MEC levels <8.3 ng/mL. Duration of AD and SCORAD index score did not show correlation with MEC/CCL28, TECK/CCL25, periostin and zonulin levels.

Conclusion:
Low zonulin levels and high MEC/CCL28 levels in infants may show an increased association with AD.
Evaluation of Patterns of Mandibular Bone Invasion in CBCT of Patients with Oral Squamous Cell Carcinoma
Authors: Shenoy Prashanth , Archana P , Chatra Laxmikanth , Veena KM , Prabhu Rachana V. , Shetty Prathima 
Published: September 2022

Background:
One of the crucial factors in the pretreatment analysis of patients with oral squamous cell carcinoma (OSCC) is the detection of the presence of bony invasion. This will indicate aggressiveness, and its patterns may also express the conduct of the lesion. The extent of bony invasion by the tumor will alter the treatment planning and increases the morbidity rate and quality of life.

Aim:
To evaluate the mandibular invasion patterns in cone beam computed tomography (CBCT) of patients with OSCC.

Methodology:
A total of 31 CBCT images of OSCC involving the mandible with bony invasion were included and assessed for various invasion patterns. Bony invasion is classified into three patterns: erosive, infiltrative, and mixed.

Results:
Descriptive analysis was carried out to assess the frequency among various bony invasion patterns. Chi-square test was carried out to find significance between the inferior alveolar nerve canal (IANC) involvement among various patterns of OSCC, which found be to be highly significant.

Conclusion:
Erosive pattern is the common pattern observed and the mixed pattern was the most frequently associated pattern with the IANC involvement.
Critical illness color-coded warning stickers
Authors: Prasad V. S. V. , Basha Shaik Jilani , Dayal Anjul 
Published: September 2022

Background:
Pediatric visits to children's hospitals are mostly outpatient and emergency room (ER) based. In busy outpatient departments (OPD) and ERs, children are reviewed quickly, and instructions are given to parents for management at home. Communication from physicians to the parents of the child may be deficient and incomplete, due to the high workload and other priority tasks. The purpose of this study was to assess the utility of simple color-coded information stickers for the OPD/ER file of the child for parents to recognize danger signs in their child to seek help early again if required.

Subjects and Methods:
This is a prospective observational study conducted on 1036 children in the age group of 1 month–18 years at a tertiary care hospital in Telangana state of India, for 1 year from January 2018 to January 2019.

Results:
Fifty-three of the patients were male, and the majority of them were in the 1–5-year age group. The perceived utility of the stickers was 85.3% in the affirmative. Only 14.7% felt they were not useful. Reasons for revisits to the ER/OPD were fever (33%), respiratory causes (37.7%), gastroenteritis causes (18%), head injury (9%), and epistaxis (1.5%).

Conclusions:
A simple color-coded sticker system used in busy OPDs and ERs in children's hospitals might prove to be a low-cost-effective communication tool for parents to utilize to recognize danger signs and report back for care when necessary.
Incidence of new morbidity based on Functional Status Scale in children on discharge from pediatric intensive care unit of a developing country
Authors: Haque Anwarul , Bhatti Shoaib , Ahmed Saira A , Muhammad I Zafar 
Published: September 2022

Background:
Recently, short-term outcome among survival of children from pediatric intensive care unit (PICU) is assessed using the Functional Status Scale (FSS). New morbidity was defined as an increase in FSS score of ≥3 points from baseline to discharge from PICU. The objective of the study was to assess the incidence of newly acquired morbidity based on FSS in children on discharge from PICU.

Subjects and Methods:
A cross-sectional retrospective study was conducted on children (1 month–15 years) who were discharged alive from PICU from November 2021 to January 2022. The functional status was evaluated using FSS on the 1st day of admission and discharge from PICU to measure newly acquired morbidity.

Results:
Of a total of 200 patients, 155 patients were included in the study. The mean age was 3.79 ± 3.76 years, and 63.2% (98) were male. The mean PRISM score was 12.99 ± 5.22. The most common diagnostic categories were acute respiratory illnesses (41.3%) and infectious diseases (23.2%). The median FSS was 6.00 on admission, and the mean FSS on discharge was 7.02 ± 2.22. The incidence of morbidity was 12.2% (19/155). Young children and children with neurological diseases were highly associated with new morbidity in critically ill children on discharge from PICU. However, there was no statistical significance. The mortality rate was 11.5% during the same period.

Conclusions:
The incidence of new morbidity in critically ill pediatric patients at PICU discharge was 12.2%. Young age and children with neurological diseases were at high risk for new morbidity. Most of the patients (>94%) were discharged with good functional status.
Acute myocardial infarction post-gastrointestinal bleeding
Authors: Su Xin , Li Junlei , Du Lijuan , Wei Yuzhen , Li Haiyu , Sang Haiqiang 
Published: September 2022

Background:
Gastrointestinal bleeding (GIB) complicating acute myocardial infarction (AMI) is a severe clinical condition with treatment contradiction and poor prognosis. This study aimed to evaluate the rate of in-hospital mortality in patients with GIB who subsequently suffered from AMI and to explore the potential risk factors for this condition.

Methods:
In this retrospective study, a total of 77 patients diagnosed with GIB, who subsequently suffered from AMI, were enrolled from January 2013 to March 2022. Demographic, laboratory, and clinical data were collected. The in-hospital mortality was the outcome of interest. Logistic regression analysis was used to investigate the potential risk factors of in-hospital mortality.

Results:
Among the 77 patients included in this study, 62 (80.52%) were males. The mean age of patients was 65.88 ± 12.15 years, and 48 patients (62.34%) were non-ST-segment elevation myocardial infarction (NSTEMI). There were 16 (20.78%) cases of in-hospital deaths. The subjects who died showed higher levels of white blood cell count (13.05 ± 5.76 vs. 9.31 ± 4.07 × 109/L, P = 0.003) and troponin I (TnI) (9.23 ± 9.17 vs. 4.12 ± 5.03 μg/L, P = 0.003). Besides, there were higher proportions of cardiogenic shock (81.25% vs. 26.23%, P < 0.001) and mechanical ventilator usage (75.0% vs. 11.48%, P < 0.001) among the patients who died. The multivariate logistic regression analysis showed that white blood cell count (odds ratio [OR] 1.19, 95% confidence interval [CI] 1.02–1.39, P = 0.030), cardiogenic shock (OR 12.18, 95% CI 3.06–48.39, P = 0.017), and mechanical ventilator usage (OR 7.21, 95% CI 1.28–40.51, P = 0.025) were independently associated with in-hospital mortality.

Conclusions:
The in-hospital mortality of patients with GIB who subsequently develop AMI is high. White blood cell count, cardiogenic shock, and mechanical ventilator usage are independent predictors of in-hospital mortality.
Ways to Promote Simulation in Medical Education
Authors: Potapov M. 
Published: September 2022

The results of the work of the team of the simulation center on the basis of the Medical University to promote simulation as an innovative technique in medical education are analyzed. There is an increase in the number of teachers implementing simulation technologies in the period 2010-2022. (2010 - 5; 2011 - 8; 2012 - 11; 2013 - 12; 2014 - 10; 2015 - 14; 2016 - 23; 2017 - 77; 2018 - 71; 2019 - 78; 2020 - 44; 2021 - 84; 2022 – 89). The number of students through simulation technologies has increased: 2016 - 1696; 2017 - 7115; 2018 - 9216; 2019 - 7871; 2020 - 4306; 2021 - 12555.
Readiness for Organizational Changes of Employees of Simulation Centers in Russia
Authors: Isaeva O. , Vasilyeva E. 
Published: September 2022

The article presents the results of a study of the readiness to implement organizational changes for employees of simulation centers in Russia.To study the readiness for the implementation of organizational changes of employees of simulation centers in Russia, the D. Holt questionnaire (“Readiness for organizational change”) adapted by E. Naumtseva was used. The study involved employees of simulation centers from 15 Russian cities (Nizhny Novgorod, Moscow, Krasnoyarsk, Vitebsk, Tver, Kaliningrad, Rostov-on-Don, Khabarovsk, Ryazan, Yekaterinburg, Cheboksary, Orenburg, Perm, Omsk) (N=39) .
Federal Information System "Federal Register of Information on Documents on Education and (or) Qualifications, Documents on Education" as a Type of State Control
Authors: Logvinov Yu. , Sharipova E. 
Published: September 2022

The aim of the study is to consider the current model for the construction and functioning of the Federal Information System "Federal Register of Information on Documents on Education and (or) Qualifications, Documents on Training", as a type of control and supervision in the field of education in the Russian Federation by analyzing the features systems.The system review was carried out on the basis of the Training and Accreditation Center - the Medical Simulation Center of the Botkin Hospital.
The Importance of Entrepreneurship in Joining Business World During COVID 19 Pandemic for Karang Taruna Members of Karanganyar Regency
Authors: Suprayitno Suprayitno 
Published: September 2022

This extension activity was conducted for Karang Taruna Kel. Tawangmangu, Kec. Tawangmangu, Kab. Karanganyar. The outcomes of this activity are: cheap participants' knowledge of the concept of entrepreneurship so that they have the right knowledge; benefit participants' insights on how to start a business and choose the right type of business; benefit participants' insights about possible business failures and ways to enter and resolve business failures.
This activity is carried out with the following stages: Selection of participants to the community service, namely the board and members of Karang Taruna; Submission of lecture materials, with a view to fostering an entrepreneurial spirit; Implementation of evaluation Evaluation is done by: before counseling conducted a question-answer to know each participant's initial knowledge about entrepreneurship special techniques or how to start a business. After the counseling finished the question and answer again about the same material. By comparing the results of answers that have been done, it will be known whether there is an increase in knowledge about the entrepreneurship and scope.
THE JEWISH CANDIDATES OF THE FREE REPUBLIC PARTY AND THE JEWISH VOTERS IN THE 1930 MUNICIPAL ELECTIONS
Authors: DURAN Mehmet Ali 
Published: September 2022

1930 yılında gerçekleşen belediye seçimleri Türkiye’deki modern anlamda belediyecilik ve yerel yönetim yapılanması için büyük bir gelişme teşkil etmiştir. Bu seçimler aynı zamanda Türk demokrasi tarihinde de seçim sistemi ve çok partili hayata geçiş için önemli bir deneme olmuştur. Bu seçimler günümüze kadar hem yerel yönetimler hem de demokrasi alanında süregelen birçok konuda olumlu veya olumsuz anlamda bir başlangıç olmuştur. Bu seçimler hem demokrasi hem yerel yönetimler hem de kadın hakları açısından bir kırılma olarak kabul edilebilir. Türk kadını ilk kez seçme seçilme hakkını kullanmıştır.
SCF’nin kuruluşunun Türk siyasal tarihi için getirdiği diğer bir yenilik de gayrimüslimlere seçilme hakkı tanıyarak Yahudi, Rum, Ermeni adaylar göstermesi olmuştur. İstanbul’da gösterilmiş Yahudi adaylar hem seçimlerde oyların SCF’ye yönelişlerine hem de seçim propagandalarında Yahudilerin de yer almasına neden olmuştur. İstanbul’daki belediye seçimlerinde Yahudilerin yoğun olarak yaşadığı ilçelerde bu cemaate mensup erkek ve kadınların SCF lehine oldukları, seçimlerde bu fırka için çalıştıkları görülmüştür. Çalışmada; Türk siyasetinde önemli bir dönüm noktası olan Serbest Cumhuriyet Fırkasının (SCF) kuruluşu, 1930 belediye seçimleri, fırkanın İstanbul teşkilatı ve Gayrimüslimler özelinde Yahudilerin ilişkisi incelenmiştir. Ayrıca İstanbul belediye seçimlerinde buradaki Yahudilerin siyasetteki rolünün önemine değinilmiştir.
Corporate Governance Index, Financial Performance, Access to Finance and Bankruptcy Prediction: Evidence from Sugar Sector of Pakistan
Authors: Iqbal Javed , Masood Arbab 
Published: September 2022

The purpose of this study is to develop a corporate governance index and to investigate the influence of corporate governance index on the financial performance of firms, access to finance and bankruptcy prediction of sugar sector listed firms on Pakistan Stock Exchange during the period 2008-18. Data of 30 sugar sector firms listed on PSX have been used for analysis. Corporate governance index is developed on the basis of 19 attributes, covering 4 broad categories: Board structure, its functionality, disclosure of information and committees of board. The fixed and random effect models have been used based on Haussmann specification test for analysis purpose. This study shows that there is a positive relationship among corporate governance based on corporate governance index and firm performance when performance is measured in term of market capitalization and it has negative relationship when performance of a firm is measured is terms of return of assets, return on equity and net profit marginal. Further corporate governance index has positive relationship with access to finance when it is measured with KZ index and SA index while there is no direct relationship observed among corporate governance index and access to finance when measured by WW index. The results of the study shows that there is positive linkage among corporate governance index and bankruptcy prediction when bankruptcy prediction is measured by Working Capital/Total Asset ratio and negative relationship with bankruptcy predictions when measured by using Retained Earnings/ Total Asset, Earnings before interest and taxes/ Total Asset, Sales/ Total Asset, Cash flow/Total debt, Net income/ Total Asset and Total debt / Total Asset ratios. Results of the study suggest that good corporate governance practices lead towards better firms financial performance and improves the chances to acquire finance.
INDIVIDUAL FACTORS INFLUENCING BLENDED LEARNING AMONG STUDENTS IN KENYA MEDICAL TRAINING COLLEGE
Authors: Tibi Tibi , Regina Bonareri , Musyoka Kainde , Okumu Winstone , Anyango Candy , Mutiria Ben 
Published: September 2022

Purpose: The objective was to determine the individual factors of blended learning among students in Kenya Medical Training College.
Methodology: A cross-sectional descriptive study was done. In the KMTC campuses the average student population is thirty thousand (30,000). The research used simple random sampling in the selected campuses. The sample size was 384. Primary data was collected using questionnaires and Quantitative data was analyzed using descriptive statistics whereas qualitative data was analyzed using content analysis. Qualitative data was transformed into themes and analyzed with the helped of SPSS version 25. Collected data was edited, sorted, cleaned and coded for data analysis.
Findings: The study revealed that Student’s departments, course of study and level of study have an influence in achievement of blended learning. There is an association at 5% significant level between having a device to use in online learning and attending virtual classes, χ2 (1, N= 396) = 4.393, p = 0.036. The Phi = .105, p = .036. At 5% significance level, there is an association between student’s proficiency in using learning applications and the percentage of attending virtual classes, χ2 (6, N= 230) = 16.889, p = .010.
Unique contribution to Theory, Practice and Policy: The study recommends that departments should be strengthened to offer both virtual and face to face sessions The College should ensure that students participating in blended-Learning courses have access to adequate and appropriate learning resources. Students have access to Page Library and also the virtual library resources within the College.