bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical prognostic value of lncRNA FOXP4-AS1 in cancer patients: A meta-analysis and bioinformatics analysis based on TCGA datasets
Authors: Shu Qiang , Liu Xiaoling , Yang Jushu , Mou Tinggang , Xie Fei 
Published: October 2022

Background:
The mortality and recurrence of patients with cancer is of high prevalence. Long non-coding RNA (lncRNA) forkhead box P4 antisense RNA 1 (FOXP4-AS1) is a promising lncRNA. There is increasing evidence that lncRNA FOXP4-AS1 is abnormally expressed in various tumors and is associated with cancer prognosis. This study was designed to identify the prognostic value of lncRNA FOXP4-AS1 in human malignancies.

Methods:
We searched electronic databases up to April 29, 2022, including PubMed, Cochrane Library, Embase, MEDLINE, and Web of Science. Eligible studies that evaluated the clinicopathological and prognostic role of lncRNA FOXP4-AS1 in patients with malignant tumors were included. The pooled odds ratios (ORs) and the hazard ratios (HRs) were calculated to assess the role of lncRNA FOXP4-AS1 using Stata/SE 16.1 software.

Results:
A total of 6 studies on cancer patients were included in the present meta-analysis. The combined results revealed that high expression of lncRNA FOXP4-AS1 was significantly associated with unfavorable overall survival (OS) (HR = 1.99, 95% confidence interval [CI]: 1.65–2.39, P < .00001), and poor disease-free survival (DFS) (HR = 1.81, 95% CI: 1.54–2.13, P < .00001) in a variety of cancers. In additional, the increase in lncRNA FOXP4-AS1 expression was also correlated with tumor size ((larger vs smaller) (OR = 3.16, 95% CI: 2.12–4.71, P < .00001), alpha-fetoprotein (≥400 vs <400) (OR = 3.81, 95%CI: 2.38–6.11, P = .83), lymph node metastasis (positive vs negative) (OR = 2.93, 95%CI: 1.51–5.68, P = .001), and age (younger vs older) (OR = 2.06, 95% CI: 1.41–3.00, P = .00002) in patients with cancer. Furthermore, analysis results using The Cancer Genome Atlas (TCGA) dataset showed that the expression level of lncRNA FOXP4-AS1 was higher in most tumor tissues than in the corresponding normal tissues, which predicted a worse prognosis.

Conclusions:
In this meta-analysis, we demonstrate that high lncRNA FOXP4-AS1 expression may become a potential marker to predict cancer prognosis.
Crowd inputs in reward-based and equity-based crowdfunding: a latent Dirichlet allocation approach on their potential for innovation
Authors: Crocco Edoardo , Giacosa Elisa , Yahiaoui Dorra , Culasso Francesca 
Published: October 2022

PurposeCrowdfunding platforms are important innovations that allow nascent entrepreneurs to gain access to financial resources and crowd inputs to better refine and develop their business idea. The purpose of this paper is to investigate user-generated content (UGC) from both reward-based and equity-based crowdfunding platforms, in order to determine its implications for open and user innovation.Design/methodology/approachA total sample of 200 most funded technology products was extracted from four distinct crowdfunding platforms. A latent Dirichlet allocation (LDA) analysis was performed in an attempt to identify critical latent factors. The analysis was carried out through the theoretical lens of innovation literature, in an attempt to uncover the implications for open and user innovation.FindingsThe authors were able to highlight the implications of crowd inputs for open and user innovation, as backers provided nascent entrepreneurs with several types of feedback, ranging from product co-development to strategy and marketing. Furthermore, the study provided an overview of the key differences emerging between reward-based and equity-based crowdfunding platforms in terms of crowd inputs.Research limitations/implicationsThe present study features intrinsic limitations of the LDA approach being adopted. More specifically, it only provides a “snapshot” in time of the current sample, rather than investigating its development over time.Practical implicationsThe present study solidifies the value of UGC as a resource to mine for trends and feedback.Originality/valueThe study contributes to both the innovation literature and the crowdfunding literature. It bridges several gaps found in both literature streams, by providing empirical evidence to test and verify pre-existing exploratory research.
Precedents of the compulsive use of a credit card: an analysis of university students' buying behavior
Authors: Felipe Israel José dos Santos , Silva Michelle Machado , Ceribeli Harrison Bachion 
Published: October 2022

PurposeThis study aims to identify the precedents of compulsively using a credit card, analyzing the influence of the following factors: power–prestige, anxiety, distrust and materialism.Design/methodology/approachData collection was performed by the survey method, while the structural equation modeling technique was used for data analysis, adopting the confirmatory factor analysis and path analysis.FindingsThe impact that anxiety has on compulsive use of credit cards was confirmed. Furthermore, the influence of materialism present in an individual on the compulsive use of a credit card was also proven.Research limitations/implicationsAs a limitation, the power–prestige construction did not obtain satisfactory average variance extracted in the modeling. Other limitations can be pointed out; for instance, it was a sample composed of university students and with geographic restrictions.Practical implicationsThis study highlights the importance of promoting public policies oriented toward the conscious use of credit cards. Interference in the approach of financial institutions aimed at attracting new clients in universities is also necessary.Social implicationsThis study aggregates information about the buying behavior of university students, how the precedents affect credit card use behavior and the harmful effects of compulsive use of credit cards.Originality/valueThe originality of this study is in offering a new approach to credit cards by analyzing their usage behavior, more specifically, the compulsive use of credit cards.
Caregiving fathers and the negotiation of crossroads: Journeys of continuity and change
Authors: Hodkinson Paul , Brooks Rachel 
Published: October 2022

AbstractThis article addresses the sustainability of extensive paternal involvement in caregiving by applying a temporal approach to understandings of the journeys of primary‐ and equal‐carer fathers and their families. Drawing on a second phase of interviews with UK fathers first spoken to 5 years earlier, we explore continuities and changes in their roles, identities and outlooks as their caregiving journeys progressed and their children became older. Specifically, we explore how fathers and their families negotiated significant moments of change that had the potential to prompt reflection or reorientation, moments that we termcaregiving crossroads. Through doing so, we highlight how, in spite of shifts in their arrangements and understandings, the embeddedness of fathers' caregiving routines, bonds and identities had apparently enabled their commitment to counter‐normative roles to endure through such crossroads. We also outline, however, how gendered limitations to some aspects of the scope of their caregiving seemed also to persist as their journeys as fathers progressed.
The effects of dietary patterns and food groups on symptomatic osteoarthritis: A systematic review
Authors: Zeng Jiayu , Franklin Daniella Kate , Das Arpita , Hirani Vasant 
Published: October 2022

AbstractAimTo systematically review current literature to determine the association between symptomatic osteoarthritis and dietary patterns, diet quality and food groups in adults aged ≥45 years.MethodsThe review was registered on PROSPERO (CRD42021270891). Cochrane Central Library, Cumulative Index of Nursing and Allied Health Literature, Embase, Medline and Web of Science databases were searched. A total of 3816 records were identified. Eligible articles involved populations aged ≥45 years with symptomatic osteoarthritis, assessing dietary patterns, diet quality or food groups, with pain in joints as outcomes. The Joanna Briggs Institute Critical Appraisal Checklists were used for quality assessment. Grading of Recommendations, Assessment, Development and Evaluation was used to assess the certainty of evidence.ResultsSix cohort studies were included. The Prudent dietary pattern and the Mediterranean dietary pattern reduced the progression of osteoarthritis symptoms. The Western dietary pattern increased symptomatic osteoarthritis progression. Increased total fibre consumption reduced symptomatic osteoarthritis progression and pain worsening, but the effects of fibre from each food group were inconclusive. Diet with high inflammatory potential increased risk of new onset symptomatic osteoarthritis, but the effects of overall diet quality were inconclusive.ConclusionsThe Prudent dietary pattern showed the highest protection on symptomatic osteoarthritis in adults aged 45 years and over. The body of evidence is limited, suggesting that further research is needed to corroborate the estimated effect at a high certainty of evidence, and to incorporate previously unstudied dietary patterns and food groups. Identifying the most beneficial dietary pattern may inform future guidelines for reducing symptomatic osteoarthritis in middle aged and older adults.
Abutment margin levels and residual cement occurrence in cement‐retained implant restorations: An observational study
Authors: Kim Hyun Ju , Karasan Duygu , Park Koungjin , Kwon Ho‐Beom , Han Jung‐Suk , Lee Jae‐Hyun 
Published: October 2022

AbstractObjectivesTo evaluate the association between different vertical levels of the abutment margin and residual cement prevalence in cement‐retained implant restorations with customized abutments.MethodsOne hundred and nine single‐unit cement‐retained implant restorations with a screw‐access channel were included. The crowns were intraorally cemented on the abutments, and excess cement was removed. The abutment–crown complex was unscrewed, and the abutment–crown complex and peri‐implant tissue were photographed. Residual cement presence was recorded by dividing the abutment–crown complex and peri‐implant tissue into four quadrants: mesial, distal, buccal, and lingual. The prevalence of residual cement was compared according to the height of the custom abutment margin of the corresponding quadrant. A multilevel model was used for statistical analysis (α = .05).ResultsCement remnants were discovered on 72.48% of the dental implants. When the restoration quadrants were compared, cement remnants were present on 51.38%, 39.45%, 20.18%, and 17.43% of the mesial, distal, buccal, and lingual surfaces, respectively (p < .01). Regarding the abutment margin level, cement residues were found in 60.22% and 61.4% of the 0.5 mm subgingival and ≥1 mm subgingival margin groups, respectively, which were significantly more than those in the supragingival (23.65%) and equigingival (26.59%) margin groups (p < .01). After adjustment for confounding factors, the adjusted odds ratio (with 95% confidence interval) for residual cement in the subgingival margin groups was 3.664 (1.71, 7.852) when compared to the supragingival and equigingival margin groups.ConclusionsThe risk of residual cement occurrence was 3.66‐fold higher with a subgingival abutment margin than with supragingival and equigingival abutment margins.
Linking changes in species composition and biomass in a globally distributed grassland experiment
Authors: Ladouceur Emma , Blowes Shane A. , Chase Jonathan M. , Clark Adam T. , Garbowski Magda , Alberti Juan , Arnillas Carlos Alberto , Bakker Jonathan D. , Barrio Isabel C. , Bharath Siddharth , Borer Elizabeth T. , Brudvig Lars A. , Cadotte Marc W. , Chen Qingqing , Collins Scott L. , Dickman Christopher R. , Donohue Ian , Du Guozhen , Ebeling Anne , Eisenhauer Nico , Fay Philip A. , Hagenah Nicole , Hautier Yann , Jentsch Anke , Jónsdóttir Ingibjörg S. , Komatsu Kimberly , MacDougall Andrew , Martina Jason P. , Moore Joslin L. , Morgan John W. , Peri Pablo L. , Power Sally A. , Ren Zhengwei , Risch Anita C. , Roscher Christiane , Schuchardt Max A. , Seabloom Eric W. , Stevens Carly J. , Veen G.F. (Ciska) , Virtanen Risto , Wardle Glenda M. , Wilfahrt Peter A. , Harpole W. Stanley 
Published: October 2022

AbstractGlobal change drivers, such as anthropogenic nutrient inputs, are increasing globally. Nutrient deposition simultaneously alters plant biodiversity, species composition and ecosystem processes like aboveground biomass production. These changes are underpinned by species extinction, colonisation and shifting relative abundance. Here, we use the Price equation to quantify and link the contributions of species that are lost, gained or that persist to change in aboveground biomass in 59 experimental grassland sites. Under ambient (control) conditions, compositional and biomass turnover was high, and losses (i.e. local extinctions) were balanced by gains (i.e. colonisation). Under fertilisation, the decline in species richness resulted from increased species loss and decreases in species gained. Biomass increase under fertilisation resulted mostly from species that persist and to a lesser extent from species gained. Drivers of ecological change can interact relatively independently with diversity, composition and ecosystem processes and functions such as aboveground biomass due to the individual contributions of species lost, gained or persisting.
Immunoparalysis in critically ill children
Authors: Neves Filipa Loureiro , Amaral Mariana Nunes Gonçalves Afonso , da Silva Sandra Filomena Durães , Silva Isabel Maria Melo , Laranjeira Paula Margarida dos Santos , Pinto Carla Regina de Jesus , Paiva Artur Augusto , Dias Andrea Sofia da Silva , Coelho Maria Leonor Almeida Carvalho Vieira 
Published: October 2022

AbstractImmunoparalysis is associated with poorer outcomes in the paediatric intensive care unit (PICU) setting. We aimed to determine the group of patients with higher chances of immunoparalysis and correlate this status with increased risks of nosocomial infection and adverse clinical parameters. We conducted an exploratory study with prospective data collection in a university‐affiliated tertiary medical, surgical, and cardiac PICU. Fifteen patients with multiple organ dysfunction syndrome were included over a period of 6 months. Monocyte's human leucocyte antigen (HLA)‐DR expression and tumour necrosis factor (TNF)‐α and interleukin (IL)‐6 production were measured by flow‐cytometry at three time points (T1 = 1–2 days; T2 = 3–5 days; T3 = 6–8 days). Using the paediatric logistic organ dysfunction‐2 score to assess initial disease severity, we established the optimal cut‐off values of the evaluated parameters to identify the subset of patients with a higher probability of immunoparalysis. A comparative analysis was performed between them. Sixty per cent were males; the median age was 4.1 years. Considering the presence of two criteria in T1 (classical monocytes mean fluorescence intensity [MFI] for HLA‐DR ≤ 1758.5, area under the curve (AUC) = 0.775; and frequency of monocytes producing IL‐6 ≤ 68.5%, AUC = 0.905) or in T3 (classical monocytes MFI of HLA‐DR ≤ 2587.5, AUC = 0.675; and frequency of monocytes producing TNF‐α ≤ 93.5%, AUC = 0.833), a variable to define immunoparalysis was obtained (100% sensitivity, 81.5% specificity). Forty per cent of patients were assigned to the immunoparalysis group. In this: a higher frequency of nosocomial infection (p = 0.011), vasoactive inotropic score (p = 0.014) and length of hospital stay (p = 0.036) was observed. In the subgroup with the diagnosis of sepsis/septic shock (n = 5), patients showed higher percentages of non‐classical monocytes (p = 0.004). No mortality was recorded. A reduction in classical monocytes HLA‐DR expression with lower frequencies of monocytes producing TNF‐α and IL‐6 during the first week of critical illness, appears to be a good marker of immunoparalysis; these findings relate to an increased risk of nosocomial infection and deleterious outcomes. The increased frequency of non‐classical monocytes in patients with sepsis/septic shock is suggestive of a better prognosis.
Phytoremediation of isoproturon‐contaminated sites by transgenic soybean
Authors: Kong Xiangkun , Lv Na , Liu Songmeng , Xu Hui , Huang Junwei , Xie Xiangting , Tao Qing , Wang Baozhan , Ji Rong , Zhang Qun , Jiang Jiandong 
Published: October 2022

SummaryThe widespread application of isoproturon (IPU) can cause serious pollution to the environment and threaten ecological functions. In this study, the IPU bacterial N‐demethylase gene pdmAB was transferred and expressed in the chloroplast of soybean (Glycine max L. ‘Zhonghuang13’). The transgenic soybeans exhibited significant tolerance to IPU and demethylated IPU to a less phytotoxic metabolite 3‐(4‐isopropylphenyl)‐1‐methylurea (MDIPU) in vivo. The transgenic soybeans removed 98% and 84% IPU from water and soil within 5 and 14 days, respectively, while accumulating less IPU in plant tissues compared with the wild‐type (WT). Under IPU stress, transgenic soybeans showed a higher symbiotic nitrogen fixation performance (with higher total nodule biomass and nitrogenase activity) and a more stable rhizosphere bacterial community than the WT. This study developed a transgenic (TS) soybean capable of efficiently removing IPU from its growing environment and recovering a high‐symbiotic nitrogen fixation capacity under IPU stress, and provides new insights into the interactions between rhizosphere microorganisms and TS legumes under herbicide stress.
Belief as emotion
Authors: McCormick Miriam Schleifer 
Published: October 2022

AbstractIt is commonly held that (i) beliefs are revisable in the face of counter‐evidence and (ii) beliefs are connected to actions in reliable and predictable ways. Given such a view, many argue that if a mental state fails to respond to evidence or doesn't result in the kind of behavior typical or expected of belief, it is not a belief after all, but a different state. Yet, one finds seeming counter examples of resilient beliefs that fail to respond to evidence, or that do not connect to action in the way that is expected. I offer a view of belief that does not force us to exclude states as realbeliefs that we pre‐reflectively think of as beliefs, and that does not require us to “outsource” the work belief seems to do to other mental states. I propose that we view belief as a type of emotion where emotions are understood a irreducibly blended states, containing representational, motivational and phenomenological elements.
Peltate trichomes in the dormant shoot apex of Metrodorea nigra, a Rutaceae species with rhythmic growth
Authors: Machado S. R. , de Deus Bento K. B. , Canaveze Y. , Rodrigues T. M. 
Published: October 2022

Abstract

In Metrodorea nigra, a Rutaceae species with rhythmic growth, the shoot apex in the dormant stage is enclosed by modified stipules. The young organs are fully covered with peltate secretory trichomes, and these structures remain immersed in a hyaline exudate within a hood‐shaped structure. Our study focused on the morpho‐functional characterization of the peltate trichomes and cytological events associated with secretion.

Shoot apices were collected during both dormant and active stages and processed for anatomical, cytochemical and ultrastructural studies.

Trichomes initiate secretion early on, remain active throughout leaf development, but collapse as the leaves expand; at which time secretory cavities start differentiation in the mesophyll and secretion increases as the leaf reaches full expansion. The subcellular apparatus of the trichome head cells is consistent with hydrophilic and lipophilic secretion. Secretion involves two vesicle types: the smaller vesicles are PATAg‐positive (periodic acid/thiocarbohydrazide/silver proteinate) for carbohydrates and the larger ones are PATAg‐negative. In the first phase of secretory activity, the vesicles containing polysaccharides discharge their contents through exocytosis with the secretion accumulating beneath the cuticle, which detaches from the cell wall. Later, a massive discharge of lipophilic substances (lipids and terpenes/phenols) results in their accumulation between the wall and cuticle. Release of the secretions occurs throughout the cuticular microchannels.

Continued protection of the leaves throughout shoot development is ensured by replacement of the collapsed secretory trichomes by oil‐secreting cavities. Our findings provide new perspectives for understanding secretion regulation in shoot apices of woody species with rhythmic growth.
Medical student education simulation competitions
Authors: Pajor Michael , Xie Nicholas , Podolej Gregory 
Published: October 2022

AbstractBackgroundSim Wars is a simulation‐based competition wherein teams of medical trainees are presented a clinical scenario and provide patient care in front of a live audience. This non‐traditional educational offering is a form of serious games in medical education and allows for experiential learning via direct observation. Although a well‐described educational modality within graduate medical education, there is a dearth of literature regarding Sim Wars as an educational tool within undergraduate medical education. In this paper, we aim to share student perspectives after participating in Sim Wars.ApproachThe Sim Wars competition was designed as a double‐elimination bracket tournament with arena‐style direct observation to maximise student engagement. Teams were provided formative feedback in areas of medical knowledge, clinical management and communication skills. A total of 64 students participated in a regional Sim Wars tournament over the course of 2 years.EvaluationA total of 36 students completed Likert‐based surveys immediately after the Sim Wars competition. Quantitative data and open‐ended responses were analysed. Fourteen students participated in focus groups held a few months after Sim Wars regarding their experiences during the competition. Thematic analysis was systematically performed on the qualitative data.ImplicationParticipation in Sim Wars was viewed by students as a high‐yield learning experience that increased competence on subsequent clinical rotations. We conclude that this form of serious game can be a highly beneficial educational format for medical students especially if they spend time preparing for the competition and receive structured feedback on their performance.
“Freshwater Components” in the Populations of Whitespotted Char Salvelinus leucomaenis (Salmonidae) in the North of the Species Range (Kamchatka)
Authors: Kuzishchin K. V. , Gruzdeva M. A. , Malyutina A. M. , Pavlov D. S. 
Published: October 2022

Abstract
The variety of types of life strategy and the structure of the populations of whitespotted char Salvelinus leucomaenis (Pallas, 1814) are considered at Kamchatka. At the north of the species range, the populations of whitespotted char are heterogeneous. The main role in reproduction belongs to anadromous whitespotted char, but there are also the groups in the populations that realize their life cycle exclusively in fresh waters. Dwarf males are common in the rivers of different types. In the geomorphologically complex river (Kol), there is also the river populations of rheodromous whitespotted char, represented by males and females. Favorite biotopes (blockages and creases of woody material on deep reaches, found only in foothill rivers) are key parameters predetermining the presence of a river population of rheodromous whitespotted char. At the north of the species range, the variety of individuals with different types of life strategy in whitespotted char is comparable to that observed in the southern parts, in particular, in the basin of the Sea of Japan, which is considered the zone of the ecological optimum of the species.