bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glycyrrhizin, an inhibitor of HMGB1 induces autolysosomal degradation function and inhibits H. pylori infection
Authors: Khan Uzma , Karmakar Bipul Chandra , Basak Priyanka , Paul Sangita , Gope Animesh , Sarkar Deotima , Mukhopadhyay Asish Kumar , Dutta Shanta , Bhattacharya Sushmita 
Published: August 2022

AbstractHelicobacter pylori a key agent for causing gastric complications is linked with peptic ulcer, gastritis, and in severe cases gastric cancer. In response to infection, host cells stimulate autophagy to maintain cellular homeostasis. However, H. pylori have evolved the ability to usurp the host’s autophagic machinery. High mobility group box1 (HMGB1), an alarmin molecule is a regulator of autophagy and its expression is augmented in gastric cancer and many other cancers. Therefore, this study aims to explore the role of glycyrrhizin (a known inhibitor of HMGB1) in autophagy during H. pylori infection. Human gastric cancer (AGS) cells were infected with H. pylori SS1 strain and further treatment was done with glycyrrhizin. Western blot was used to examine the expression levels of autophagy proteins. Autophagy and lysosomal activity were monitored by immunofluorescence. We have performed knockdown of HMGB1 to verify the effect of glycyrrhizin by siRNA transfection method. H. pylori-infection in vivo C56BL/6 mice model was established and the effect of glycyrrhizin treatment was studied. We found that the autophagy-lysosomal pathway was impaired due to a significant increase in lysosomal membrane permeabilization during H. pylori infection in AGS cells. Subsequently, glycyrrhizin treatment restored the lysosomal membrane integrity, accompanied by an increase in cathepsin B activity and reduction of ROS and inflammatory cytokine IL-8. The recovered lysosomal function enhanced autolysosome formation and concomitantly attenuated the intracellular H. pylori growth by eliminating the pathogenic niche from gastric cells. Additionally, glycyrrhizin treatment inhibited inflammation and improved gastric tissue damages in mice.
Sample size bias in the empirical assessment of the acute risks associated with Daylight Saving Time transitions
Authors: Martín-Olalla José María , Mira Jorge 
Published: August 2022

The assessment of the acute impact of Daylight Saving Time (DST) transitions is a question of great interest for an understanding of the benefits and inconveniences of a practice that is now under public scrutiny in Europe and America.Here we report a thorough analysis of a record of twelve well-known research studies that re- ported increased risks associated with DST transitions in health issues —acute myocardial infarction, ischemic strokes— and in societal issues —accidents, traffic accidents and fatal motor vehicle accidents—.We found that a 5% increase of the risks suffices to understand the reported increased risks associated with the spring transition. Reported values above this threshold are impacted by the sample size of the study.In the case of the autumn transition, no increase of the risks is found.
Coalitions in international relations and coordination of agricultural trade policies
Authors: Mao Rui 
Published: August 2022

PurposeThe author attempts to examine the existence and pattern of coalitions in international relations across countries, and investigates whether international relations of coalition partners influence a country's enaction of agricultural non-tariff measures (NTMs).Design/methodology/approachThe author adopts a machine learning technique to identify international relation coalition partnerships and use network analysis to characterize the clustering pattern of coalitions with high-frequent records of global event data. The author then constructs a monthly dataset of agricultural NTMs against China and international relations with China of each importer and its coalition partners, and designs a panel structural vector autoregressive (PSVAR) model to estimate impulse response functions of agricultural NTMs with regard to international relation shocks.FindingsThe author finds countries to establish coalition partnerships. Two major clusters of coalitions are noted, with one composed of coalitions primarily among “North” countries and the other of coalitions among “South” countries. The United States is found to play a pivotal role by connecting the two clusters. The PSVAR estimation reveals reductions of NTMs against China following improved international relations with China of both the importer and its coalition partners. NTM responses are more substantial for measures that are trade restrictive. These results confirm that coalitions in international relations lead to coordination of agricultural NTMs.Originality/valueThe author provides international political insights into agricultural trade policymaking by showing interactions of NTM enaction across countries in the same coalition of international relations. These insights offer useful policy implications to predict and cope with hidden barriers to agricultural trade.
Redefining knowledge hiding in the workplace: an in-depth qualitative study
Authors: Swain Deepika , Jena Lalatendu Kesari 
Published: August 2022

Purpose
To propose a newer perspective for an often-tabooed knowledge hiding by highlighting the socio-psychological experiences in knowledge sharing.

Design/methodology/approach
An in-depth interviewing process was adopted to study the influencers of knowledge flow, taking 42 educators of the online teaching platforms.

Findings
Unrelatedness, supervision, and engagement propelled knowledge sharing-conducive ambiance, contrary to the conclusions of the earlier studies.

Originality/value
Emerged themes established a connection between knowledge sharing, and the feel-good factor, promoting future researchers to extend it to higher psychological order approaches like Guanxi, Mianzi, and Ikigai.
Boat: the Indian startup scripts a revolutionizing growth strategy
Authors: Bhargava Sheela , Gupta Parul 
Published: August 2022

Learning outcomesThe case will help learners to analyse how effective handling of an extended marketing mix of 7Ps (product, price, place, promotion, physical evidence, participants and processes) makes a startup profitable in its initial years of inception; understand the significance of the online marketing strategies like digital marketing and social media marketing implemented by firms to attain a competitive edge amongst established local and global competitors; examine the strategic challenges faced by a business enterprise while entering an emerging market; analyse the growth strategies of a startup relative to various market constraints; and propose long-term strategies for sustainable growth for a startup operating in the wearables market.Case overview/synopsisFounded in 2016, Boat Lifestyle is a Delhi-based Indian startup in fashionable consumer electronics. In the past five years, Boat earned remarkable profits and emerged as one of the most promising startups through its innovative products offerings and promotion. Aiming at its target customer segment, the millennials, it promoted its products through social media marketing such as influencer marketing and brand tie-ins with sports teams and music events. The case focuses on the dynamics of the Indian wearables market that is facing tough competition from global and local players. To ensure continued growth prospects, while maintaining a tight focus on product differentiation, quality, and customer satisfaction, there is a greater need for Boat to rethink its market development and growth strategies regarding new innovations and adopting long-term orientation like diversification and global expansion.Complexity academic levelThe case aims for teaching business management students at the Undergraduate, Postgraduate, and Executive education level. In addition, the case can be related to the Strategic Management course curriculum and Marketing course curriculum.Supplementary materialsTeaching notes are available for educators only.Subject codeCSS 11: Strategy
Union-enterprise guanxi and union instrumentality: an empirical study in Taiwan
Authors: Guo Jia-Bo , Lin Hao-Chieh , Wang Yi-Hsien 
Published: August 2022

Purpose
Because of the interest of enterprises and unions are often conflicting. For unions, how to promote union instrumentality is a critical issue. This study aims to apply the resource dependence theory to examine the role of cooperative approach to conflict in the relationship between union–enterprise guanxi and union instrumentality under the moderation of union leader humility.

Design/methodology/approach
A questionnaire survey was undertaken to collect data from enterprise human resource (HR) manager and union stewards in Taiwanese firms using a dyadic approach. Hierarchical regression analysis and bootstrapping with a mediation model and moderated-mediation model were used to test the hypotheses.

Findings
The results show that cooperative approach to conflict is a prominent mediator between union–enterprise guanxi and union instrumentality, while union leader humility strengthens the positive association between cooperative approach to conflict and union instrumentality. Moderated-mediation analysis further demonstrates that the influence of the cooperative approach to conflict is stronger when there is a higher level of union leader humility.

Originality/value
The study offers an integrated picture about how union–enterprise social relationships promote union instrumentality.
Production of event security in Germany – empirical findings on perceptions of interorganisational collaboration between various security actors
Authors: Schütte Patricia M. , Willmes Stefan U. 
Published: August 2022

PurposeThis paper aims to explore interorganisational collaboration on event security in Germany. Therefore, it focusses on perceptions of representatives from emergency and law enforcement agencies (ELEAs) as well as commercial event stewards and security providers (ESSPs) who work together in the area. The following questions are addressed in this paper: how do the actors perceive inter-organisational collaboration on event security? In these actors' view, what factors define collaboration?Design/methodology/approachFor this study, a literature review was carried out on success-critical factors of inter-organisational collaboration at security-related settings. The results have been grouped into categories, which are assigned to sociotechnical core elements. These are the basis of a qualitative content analysis of 47 semi-structured interviews with ELEA and ESSP representatives in the context of 15 major events in Germany.FindingsThe findings support the assumption that interorganisational collaboration on event security theoretically and in the perception of on-site experts emerges as a sociotechnical system within the setting of major events. Successful collaboration is determined by human, technical and organisational factors, which interconnect the collaborating actors and ideally stabilise their work relations.Originality/valueThis article contributes to the literature regarding event and security research. The results provide insights into hitherto under-represented perspectives of stakeholders on collaboration in event security. The sociotechnical category system adds an approach for the systematic analysis of interorganisational security production.
Can housing investment hedge against inflation?
Authors: Nguyen Binh Thi Thanh 
Published: August 2022

PurposeThis paper aims to test the hedging ability of housing investment against inflation in Japan and the USA during the period 2000–2020.Design/methodology/approachThis study applies the deep learning method and The exponential general autoregressive conditional heteroskedasticity in mean (1, 1) model with breaks.FindingsWithin the asymmetric framework, it is found that housing returns (HR) can hedge against inflation in both these markets, which mentions that when investing in the housing market in Japan and the USA, investors are compensated for bearing from inflation. This result is consistent with Fisher’s hypothesis. Especially, the empirical results show that the risk-return tradeoff is available in Japan’s housing market and not available in the US housing market. Any signal of a high inflation rate – referred to as “bad news” – may cause a drop in HR in Japan and a raise in the USA.Originality/valueTo the best of the author’s knowledge, this is one of the first studies using the deep learning method (long short-term memory model) to estimate the expected/unexpected inflation rates.
Predicting challenges to student learning in a learning study: Analysing the intended object of learning
Authors: Lelinge Balli 
Published: August 2022

PurposeThis study determines which aspects of the intended object of learning (planned by teachers during the first phase of a learning study) is made discernible from a learners' perspective. In a learning study, the intended, enacted, and lived object of learning are considered. This study focuses on the learning material used by teachers while designing a lesson.Design/methodology/approachIn many learning studies, variation theory is used to design lessons, which predicts difficulties in and possibilities for student learning. The data consisted of a lesson part – instruction through a video-recorded dance choreography – employed to enhance primary school (in a Swedish context, grade 4) students' dancing skills in the subject of Physical Education and Health. The choreography comprised five different sequences, where a variation occurred when the subsequent (new) sequence was applied to the previous movement pattern. The sequences acted as building blocks, where the students' transitions from one movement pattern to another were logical and distinguishable.FindingsThe results of this study show in what way an analysis of learning material, based on variation theory, can help teachers take into account the level of complexity of the object of learning. The results also identify which parts of a lesson design can be predicted to present a higher degree of challenge and by that more difficult to grasp, especially for students with different educational needs.Originality/valueLessons may be designed based on theoretical assumptions to ensure effective classroom learning and provide guidance to teachers based on student needs.
Marketing in the livestock sector and its impact on food security in Saudi Arabia
Authors: Al-Ghaswyneh Odai Falah Mohammad 
Published: August 2022

PurposeAlthough the livestock sector is considered to be an important segment of the Saudi Arabian economy, its contribution, including the multiple sources of commercial income it provides, is underestimated. This industry provides thousands of jobs in various related sectors and meets national demand for food. This study aims to examine the impact of breeding inputs such as animal production, marketing processes and operation and legislation on livestock sector efficiency and strategic food security.Design/methodology/approachThis study adopted an exploratory approach. The sample consisted of specialists in industrial production and livestock breeders in the northern region of Saudi Arabia. The relative importance index was used to analyze the data, which was evaluated using structural equation modeling in SPSS.FindingsThe results show the significant influence of breeding inputs, markets and legislation on increasing the efficiency of the livestock sector and the impact of livestock on strategic food security. They also highlight the need to motivate governments to focus on this sector, especially by reducing taxes on breeders’ income and lowering livestock costs accordingly. The Saudi Arabian Government should also facilitate innovative agreements to create global markets for the export of surplus livestock products. In addition, a marketing process is lacking in all areas of production and the local and international marketing of livestock products, which requires the support of different sources of fodder and establishment of markets for specific types of meat slaughter, packaging and sales.Research limitations/implicationsThis research was limited to the northern region of Saudi Arabia.Practical implicationsThis study highlights the importance of marketing processes and activities according to marketing operations as they used in study instrument to explore their impact on in the marketing livestock sector for national food security strategies and guides future studies in this field.Social implicationsThis research recommends that decision-makers support marketing in the livestock sector and reduce production taxes.Originality/valueTo the best of the author’s knowledge, no previous related research has been conducted in the field of food security.
Human-driven and human-centred cybersecurity: policy-making implications
Authors: Pawlicka Aleksandra , Pawlicki Marek , Kozik Rafał , Choraś Michał 
Published: August 2022

Purpose
The purpose of this paper is to challenge the prevailing, stereotypical approach of the human aspect of cybersecurity, i.e. treating people as weakness or threat. Instead, several reflections are presented, pertaining to the ways of making cybersecurity human-centred.

Design/methodology/approach
This paper bases on the authors’ own experiences, gathered whilst working in cybersecurity projects; the resulting comments and reflections have been enriched and backed up by the results of a targeted literature study.

Findings
The findings show that the way the human aspects of cybersecurity are understood is changing, and deviates from the stereotypical approach.

Practical implications
This paper provides a number of practical recommendations for policymakers, as well as cybersecurity managers on how to make the cybersecurity more human-centred; it also inspires further research directions.

Originality/value
This paper presents a fresh, positive approach to humans in cybersecurity and opens the doors to further discourse about new paradigms in the field.
Key drivers of promoting patient safety culture from the perspective of medical staff at a tertiary hospital in China
Authors: Li Li , Wu Hsin-Hung , Huang Chih-Hsuan , Zou Yuanyang , Li Xiao Ya 
Published: August 2022

PurposeUnderstanding the antecedents of patient safety culture among medical staff is essential if hospital managers are to promote explicit patient safety policies and strategies. The factors that influence patient safety culture have received little attention. The authors aim to investigate the antecedents of patient safety culture (safety climate) in relation to medical staff to develop a comprehensive approach to improve patient safety and the quality of medical care in China.Design/methodology/approachThe Chinese version of the Safety Attitudes Questionnaire (CSAQ) was used to examine the attitudes toward patient safety among physicians and nurses. This medical staff was asked to submit the intra-organizational online survey via email. A total of 1780 questionnaires were issued. The final useable questionnaires were 256, yielding a response rate of 14.38%. One-way analysis of variance (ANOVA) was employed to test if different sex, supervisor/manager, age, working experience, and education result in different perceptions. Confirmatory factor analysis (CFA) was used to verify the structure of the data. Then linear regression with forward selection was performed to obtain the essential dimension(s) that affect the safety culture (safety climate).FindingsThe CFA results showed that 26 CSAQ items measured 6 safety-related dimensions. The linear regression results indicated that working conditions, teamwork climate, and job satisfaction had significant positive effects on safety culture (safety climate).Practical implicationsHospital managers should put increased effort into essential elements of patient-oriented safety culture, such as working conditions, teamwork climate, and job satisfaction to develop appropriate avenues to improve the quality of delivered medical services as well as the safety of patients.Originality/valueThis study focused on the contribution that the antecedents of patient safety culture (safety climate) make with reference to the perspective of medical staff in a tertiary hospital in China.
An empirical study into the reasons for failure of sustaining operational excellence initiatives in organizations
Authors: Antony Jiju , Sony Michael , McDermott Olivia , Swarnakar Vikas , Galli Brian , Doulatabadi Mehran , Kaul Rajesh 
Published: August 2022

PurposeOperational excellence (OPEX) initiatives such as Lean, Six Sigma, Lean Six Sigma and Agile have some common characteristics that can be understood through their adoption in organizations. The objective of this research is to present the results of an online survey highlighting the most critical reasons for failure of OPEX initiatives.Design/methodology/approachThis study presents the results of a survey from 106 experts from different countries who have been involved in OPEX implementation. The experts were Six Sigma Master Black Belts, Black Belts and Champions from different manufacturing and service organizations. The developed questionnaire was initially tested with the help of seven experts to ensure their technical validity and soundness.FindingsThe study found 15% of companies surveyed have not adopted any form of OPEX methodology. The top three reasons for non-adoption of OPEX were also found. In terms of the use of various OPEX methodologies, more than 75% of companies were employing Six Sigma and less than 50% were engaged in Lean initiatives. Another surprising result was that less than 5% of the companies were utilizing Kaizen and other continuous improvement methodologies for improving the efficiency and effectiveness of organizational processes. The study further finds top five failure factors for sustaining OPEX initiatives in manufacturing, service, large and small organizations.Research limitations/implicationsThe study reports the outcomes based on an online survey with limited sample size. Moreover, the number of samples from small and medium-sized enterprises (SMEs) was less than 25, and therefore it was difficult to make any robust conclusions in the comparison of failure factors between large enterprises and SMEs.Originality/valueTo the best of the authors’ knowledge, this is the first empirical study that has attempted to explore the reasons for failure of OPEX initiatives. The authors argue that a greater understanding of the reasons for failure of OPEX initiatives can provide an input to develop a framework that can mitigate the failures and costs associated with such failures.