bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single versus double Perclose techniques for vascular closure during transfemoral transcatheter aortic valve replacement
Authors: Hollowed John , Akhondi Andre , Rabbani Amir , Oncel Damla , Suh William , Rafique Asim , Kwon Murray , Benharash Peyman , Shemin Richard , Aksoy Olcay 
Published: April 2022

AbstractIntroductionThe preferred approach for transcatheter aortic valve replacement (TAVR) is transfemoral. There has been widespread adoption of the Perclose ProglideTM device for vascular closure. Typically, two devices are deployed before upsizing the access sheath in the “preclose technique.” Prior investigations have compared the use of a single device versus double device technique, but none have shown significant clinical benefit to either approach.MethodsFive hundred and six patients underwent transfemoral TAVR (TF‐TAVR) with single or double Perclose devices for vascular closure from July 2015 to February 2020. A retrospective review was conducted, and propensity‐matched analyses were used to account for differences in baseline characteristics.ResultsIn the matched analysis, there were 251 patients in the single Perclose group and 238 in the double. There was a statistically significant improvement in overall procedural success using the single closure device (94.6% vs. 88.5%, p = 0.009) This was defined as intraprocedural hemostatic control, lack of contrast extravasation, arterial dissection, occlusion, or stenosis >50% in the final crossover angiogram, as well as unimpaired limb perfusion without claudication throughout the index hospitalization. There was also a significant improvement in arterial dissection rates (0.6% vs. 4.6%, p = 0.004), stenosis >50% (1.3% vs. 4.4%, p = 0.028), and Valve Academic Research Consortium major vascular complications (1.8% vs. 4.9%, p = 0.038).ConclusionA single Perclose device is a safe means of vascular closure during TF‐TAVR and may have important clinical benefits compared to the commonly used two‐device technique.
Safety gaps in medical team communication: Closing the loop on quality improvement efforts in the cardiac catheterization lab
Authors: Doorey Andrew J. , Turi Zoltan G. , Lazzara Elizabeth H. , Casey Molly , Kolm Paul , Garratt Kirk N. , Weintraub William S. 
Published: April 2022

AbstractClosed‐loop communication (CLC) is a fundamental aspect of effective communication, critical in the cardiac catheterization laboratory (cath lab) where physician orders are verbal. Complete CLC is typically a hospital and national mandate. Deficiencies in CLC have been shown to impair quality of care. Single center observational study, CLC for physician verbal orders in the cath lab were assessed by direct observation during a 5‐year quality improvement effort. Performance feedback and educational efforts were used over this time frame to improve CLC, and the effects of each intervention assessed. Responses to verbal orders were characterized as complete (all important parameters of the order repeated, the mandated response), partial, acknowledgment only, or no response. During the first observational period of 101 cases, complete CLC occurred in 195 of 515 (38%) medication orders and 136 of 235 (50%) equipment orders. Complete CLC improved over time with various educational efforts, (p < 0.001) but in the final observation period of 117 cases, complete CLC occurred in just 259 of 328 (79%) medication orders and 439 of 581 (76%) equipment orders. Incomplete CLC was associated with medication and equipment errors. CLC of physician verbal orders was used suboptimally in this medical team setting. Baseline data indicate that physicians and staff have normalized weak, unreliable communication methods. Such lapses were associated with errors in order implementation. A subsequent 5‐year quality improvement program resulted in improvement but a sizable minority of unacceptable responses. This represents an opportunity to improve patient safety in cath labs.
Reasons for lesion uncrossability as assessed by intravascular ultrasound
Authors: Salem Hanan , Mintz Gary S. , Matsumura Mitsuaki , Zhang Mingyou , Usui Eisuke , Seike Fumiyasu , Fujimura Tatsuhiro , Noguchi Masahiko , Hu Xun , Jin Ge , Li Chenguang , Fall Khady N. , Ali Ziad A. , Kirtane Ajay J. , Collins Michael B. , Kodali Susheel K. , Nazif Tamim M. , Leon Martin B. , Moses Jeffrey W. , Karmpaliotis Dimitri , Maehara Akiko 
Published: April 2022

AbstractObjectivesThe purpose of the current study was to use intravascular ultrasound (IVUS) to clarify anatomical and morphological lesion characteristics of uncrossable lesions.BackgroundUncrossable lesions are not always severely calcified. The prevalence of uncrossable lesions that are nonseverely calcified as well as other mechanisms for uncrossability has not been well clarified.MethodsA total of 252 de novo uncrossable lesions in native coronary arteries that underwent either rotational or orbital atherectomy due to inability of any balloon to cross the lesion and 38 lesions with severe calcium in which IVUS crossed preatherectomy were included. Severe calcium is defined as maximum arc of calcium ≥270°.ResultsSevere calcification was absent in 16% of uncrossable lesions, 83% of which had a significant vessel bend. Compared with crossable lesions with severe calcium, uncrossable lesions with severe calcium more often had a bend in the vessel (71% vs. 21%, p < 0.001) and a longer length of continuous severe calcium (median length of calcium ≥270° 3.8 mm vs. 1.9 mm, p = 0.001). Other than severe calcium (especially long continuous calcium) or a bend in the vessel, anatomical factors associated with uncrossabilty were aorto‐ostial lesion location and small vessels.ConclusionsUncrossable lesions are not always severely calcified. The interaction of lesion morphology (continuous long and large arcs of calcium) and vessel geometry (bend in the vessel or ostial lesion location) affect lesion crossability.
Conversion of CH4 Catalyzed by Gas Phase Ions Containing Metals
Authors: Yang Yuan , Zhao Yan‐Xia , He Sheng‐Gui 
Published: April 2022

AbstractMethane is an abundant and cheap feedstock to produce valuable chemicals. The catalytic reaction of methane conversion generally requires the participation of multiple molecules (such as two or three CH4 molecules, O2, CO2, etc.). Such complex process includes the cleavage of original chemical bonds, formation of new chemical bonds, and desorption of products. The gas phase study provides a unique arena to gain molecular‐level insights into the detailed mechanisms of bond‐breaking and bond‐forming involved in complicated catalytic reactions. In this Review, we introduce the methane conversion catalyzed by gas phase ions containing metals and three topics will be discussed: (1) the direct coupling of methane molecules, (2) the conversion of CH4 with O2, O3 and N2O, and (3) the conversion of CH4 with CO2 and H2O. The obtained mechanistic aspects may provide new clues for rational design of better‐performing catalysts for conversion of methane to value‐added products.
The Role of Radical Bridges in Polynuclear Single‐Molecule Magnets
Authors: Nguyen Giang Truong , Ungur Liviu 
Published: April 2022

AbstractEmploying radical bridges between anisotropic metal ions has been a viable route to achieve high‐performance single‐molecule magnets (SMMs). While the bridges have been mainly considered for their ability to promote exchange interactions, the crystal‐field effect arising from them has not been taken into account explicitly. This lack of consideration may distort the understanding and limit the development of the entire family. To shed light on this aspect, herein we report a theoretical investigation of a series of N
‐radical‐bridged diterbium complexes. It is found that while promoting strong exchange coupling between the terbium ions, the N
‐radical induces a crystal field that interferes destructively with that of the outer ligands, and thus reduces the overall SMM behavior. Based on the theoretical results, we conclude that the SMM behavior in this series could be further maximized if the crystal field of the outer ligands is designed to be collinear with that of the radical bridge. This conclusion can be generalized to all exchange‐coupled SMMs.
Green‐Light Activatable BODIPY and Coumarin 5’‐Caps for Oligonucleotide Photocaging
Authors: Kaufmann Janik , Müller Patricia , Andreadou Eleni , Heckel Alexander 
Published: April 2022

AbstractWe synthesized two green‐light activatable 5’‐caps for oligonucleotides based on the BODIPY and coumarin scaffold. Both bear an alkyne functionality allowing their use in numerous biological applications. They were successfully incorporated in oligonucleotides via solid‐phase synthesis. Copper‐catalyzed alkyne‐azide cycloaddition (CuAAC) using a bisazide photo‐tether gave cyclic oligonucleotides that could be relinearized by activation with green light and were shown to exhibit high stability against exonucleases. Chemical ligation as another example for bioconjugation yielded oligonucleotides with an internal strand break site. Irradiation at 530 nm or 565 nm resulted in complete photolysis of both caging groups.
Selective Labeling of Peptides with o‐Carboranes via Manganese(I)‐Catalyzed C−H Activation
Authors: Jei Becky Bongsuiru , Yang Long , Ackermann Lutz 
Published: April 2022

AbstractA robust method for the selective labeling of peptides via manganese(I) catalysis was devised to achieve the C‐2 alkenylation of tryptophan containing peptides with 1‐ethynyl‐o‐carboranes. The manganese‐catalyzed C−H activation was accomplished with high catalytic efficiency, and featured low toxicity, high functional group tolerance and excellent E‐stereoselectivity. This approach unravels a promising tool for the assembly of o‐carborane with structurally complex peptides of relevance to applications in boron neutron capture therapy.
Characterization of Asx Turn Types and Their Connate Relationship with β‐Turns
Authors: D'mello Viola C. , Goldsztejn Gildas , Mundlapati Venkateswara Rao , Brenner Valérie , Gloaguen Eric , Charnay‐Pouget Florence , Aitken David J. , Mons Michel 
Published: April 2022

AbstractInvited for the cover of this issue are David J. Aitken, Michel Mons, and co‐workers at Université Paris–Saclay. The image depicts the investigation strategies used to document the intrinsic structures of an important secondary structure in proteins, the so‐called Asx turn. Read the full text of the article at 10.1002/chem.202104328.
Scoring systems of metabolic syndrome and prediction of cardiovascular events: A population based cohort study
Authors: Motamed Nima , Ajdarkosh Hossein , Karbalaie Niya Mohammad Hadi , Panahi Mahshid , Farahani Behzad , Rezaie Nader , Nikkhah Mehdi , Faraji Amir H. , Hemmasi Gholamreza , Perumal Dhayaneethie , Ashrafi G. Hossein , Safarnezhad Tameshkel Fahimeh , Gholizadeh Esmaeel , Khoonsari Mahmoodreza , Zamani Farhad 
Published: April 2022

AbstractBackground and AimsContinuous scoring systems were developed versus traditional dichotomous approaches to define metabolic syndrome. The current study was carried out to evaluate the ability of scoring systems to predict fatal and nonfatal cardiovascular events.Materials and MethodsThe data of 5147 individuals aged 18 years or more obtained from a population‐based cohort study were analyzed. The occurrence of atherosclerotic cardiovascular disease (ASCVD) in the period of 7 years follow‐up was considered as the associated outcome. Joint Interim Statement (JIS) definition, as a traditional definition of metabolic syndrome (MetS), and two versions of MetS scoring systems, based on standardized regression weights from structural equation modeling (SEM) and simple method for quantifying metabolic syndrome (siMS) were considered as potential predictors.ResultsThe scoring systems, particularly, based on SEM, were observed to have a significant association with composite cardiovascular events (HR = 1.388 [95% CI = 1.153–1.670], p = .001 in men and HR = 1.307 [0.95% CI = 1.120–1.526] in women) in multiple Cox proportional hazard regression analyses, whereas the traditional definition of MetS did not show any significant association. While both two scoring systems showed acceptable predictive abilities for cardiovascular events in women (MetS score based on SEM: area of under curve [AUC] = 0.7438 [95% CI = 0.6195–0.7903] and siMS: AUC = 0.7207 [95% CI = 0.6676–0.7738]), the two systems were not acceptable for identifying risk in men.ConclusionUnlike the dichotomous definition of MetS, the scoring systems showed an independent association with cardiovascular events. Scoring systems, particularly those based on SEM, may be useful for the prediction of cardiovascular events in women.
Distinguishing exercise intolerance in early‐stage pulmonary hypertension with invasive exercise hemodynamics: Rest VE/VCO2 and ETCO2 identify pulmonary vascular disease
Authors: Raza Farhan , Dharmavaram Naga , Hess Timothy , Dhingra Ravi , Runo James , Chybowski Amy , Kozitza Callyn , Batra Supria , Horn Evelyn M. , Chesler Naomi , Eldridge Marlowe 
Published: April 2022

AbstractBackgroundAmong subjects with exercise intolerance and suspected early‐stage pulmonary hypertension (PH), early identification of pulmonary vascular disease (PVD) with noninvasive methods is essential for prompt PH management.HypothesisRest gas exchange parameters (minute ventilation to carbon dioxide production ratio: VE/VCO2 and end‐tidal carbon dioxide: ETCO2) can identify PVD in early‐stage PH.MethodsWe conducted a retrospective review of 55 subjects with early‐stage PH (per echocardiogram), undergoing invasive exercise hemodynamics with cardiopulmonary exercise test to distinguish exercise intolerance mechanisms. Based on the rest and exercise hemodynamics, three distinct phenotypes were defined: (1) PVD, (2) pulmonary venous hypertension, and (3) noncardiac dyspnea (no rest or exercise PH). For all tests, *p < .05 was considered statistically significant.ResultsThe mean age was 63.3 ± 13.4 years (53% female). In the overall cohort, higher rest VE/VCO2 and lower rest ETCO2 (mm Hg) correlated with high rest and exercise pulmonary vascular resistance (PVR) (r ~ 0.5–0.6*). On receiver‐operating characteristic analysis to predict PVD (vs. non‐PVD) subjects with noninvasive metrics, area under the curve for pulmonary artery systolic pressure (echocardiogram) = 0.53, rest VE/VCO2 = 0.70* and ETCO2 = 0.73*. Based on this, optimal thresholds of rest VE/VCO2 > 40 mm Hg and rest ETCO2 < 30 mm Hg were applied to the overall cohort. Subjects with both abnormal gas exchange parameters (n = 12, vs. both normal parameters, n = 19) had an exercise PVR 5.2 ± 2.6* (vs. 1.9 ± 1.2), mPAP/CO slope with exercise 10.2 ± 6.0* (vs. 2.9 ± 2.0), and none included subjects from the noncardiac dyspnea group.ConclusionsIn a broad cohort of subjects with suspected early‐stage PH, referred for invasive exercise testing to distinguish mechanisms of exercise intolerance, rest gas exchange parameters (VE/VCO2 > 40 mm Hg and ETCO2 < 30 mm Hg) identify PVD.
Impact of Covalent Modifications on the Hydrogen Bond Strengths in Diaminotriazine Supramolecules
Authors: Petelski Andre Nicolai , Pamies Silvana Carina , Márquez María Josefina Verónica , Sosa Gladis Laura , Peruchena Nélida María 
Published: April 2022

AbstractMelamine (M) is a popular triamine triazine compound in the field of supramolecular materials. In this work, we have computationally investigated how substituents can be exploited to improve the binding strength of M supramolecules. Two types of covalent modifications were studied: the substitution of an H atom within an amine group −NHR, and the replacement of the whole −NH2 group (R=H, F, CH3 and COCH3). Through our dispersion‐corrected density functional theory computations, we explain which covalent modification will show the best self‐assembling capabilities, and why the binding energy is enhanced. Our charge density and molecular orbital analyses indicate that the best substituents are those that generate a charge accumulation on the endocyclic N atom, providing an improvement of the electrostatic attraction. At the same time the substituent assists the main N−H⋅⋅⋅N hydrogen bonds by interacting with the amino group of the other monomer. We also show how the selected group notably boosts the strength of hexameric rosettes. This research, therefore, provides molecular tools for the rational design of emerging materials based on uneven hydrogen‐bonded arrangements.
Association of lipoprotein (a) and 1 year prognosis in patients with heart failure with reduced ejection fraction
Authors: Li Zhiming , Liu Jingguang , Shen Jian , Chen Yumin , He Lizhen , Li Menghao , Xie Xiongwei 
Published: April 2022

AbstractAimCurrent study was to evaluate relationship between baseline serum lipoprotein (a) [Lp(a)] level and prognosis in patients with heart failure with reduced ejection fraction (HFrEF) and to explore whether the relationship would be modified by baseline high‐sensitivity C‐reactive protein (Hs‐CRP) level.Methods and resultsThis is an observational prospective study. HFrEF patients from outpatient clinic were consecutively recruited (n = 362). Based on Lp(a) cutoff (30 mg/dL), patients were divided into normal and high Lp(a) groups; and based on Hs‐CRP cutoff (3 mg/dL), patients were divided into low‐degree and high‐degree groups. The 1 year rate of HF rehospitalization was similar between these two groups (22.7% vs. 24.1%, P = 0.18), while the 1 year rate of cardiovascular mortality was higher in Lp(a) ≥ 30 mg/dL versus Lp(a) < 30 mg/dL groups (20.3% vs. 13.3%, P = 0.009), as was composite endpoint (44.4% vs. 36.0%, P < 0.001). After adjusting for covariates, elevated Lp(a) level remained associated with a higher risk of cardiovascular mortality [hazard ratio (HR) 1.22 and 95% confidence interval (CI) 1.04–1.64, P = 0.02] and composite endpoint (HR 1.38 and 95% CI 1.16–2.01, P = 0.006). In Hs‐CRP ≥ 3 mg/dL group, elevated Lp(a) level was associated with HF rehospitalization, cardiovascular mortality, and composite endpoint, which was not observed in Hs‐CRP < 3 mg/dL group. The association was greater for cardiovascular mortality (P‐interaction = 0.04) and composite endpoint (P‐interaction = 0.02) in Hs‐CRP ≥ 3 mg/dL versus Hs‐CRP < 3 mg/dL groups.ConclusionElevated Lp(a) level is associated with higher risk of cardiovascular mortality in HFrEF patients, which might be due to enhanced systemic inflammation.
Total Synthesis of 12,13‐Dibenzyl‐banistenoside B and Analogs
Authors: Patil Suhag S. , Jachak Gorakhnath R. , Rama Krishna Gamidi , Argade Narshinha P. , Reddy D. Srinivasa 
Published: April 2022

AbstractBanistenosides A and B possessing a unique “azepino(1,2‐a)tetrahydro‐β‐carboline” carbon framework were isolated from the stem of Banisteriopsis caapi and showed MAO‐A inhibition. Herein, we report the total synthesis of dibenzyl derivative of the untouched natural product in the last two decades, Banistenoside B. The key steps involve construction of 6.5.6.7 tetracyclic core using Pictet−Spengler reaction and intramolecular amide coupling. The stereoselective glycation was achieved through Hotha's protocol using gold catalyst, and silver triflate in the late stage of synthesis. The stereochemistry of most of the essential compounds were confirmed by X‐ray crystallography.
Flexible Prussian Blue‐Au Fibers as Robust Peroxidase – Like Nanozymes for Wearable Hydrogen Peroxide and Uric Acid Monitoring
Authors: Li Jiahui , Jiao Lei , Xiao Xiao , Nashalian Ardo , Mathur Shaurya , Zhu Zhijun , Wu Weitai , Guo Weiwei , Zhai Yanling , Lu Xiaoquan , Chen Jun 
Published: April 2022

AbstractFiber‐based electronics technology has been making significant strides towards applicable emergence into many fields. One such field is the use of fiber‐based electronics in the development of smart textiles. Here, we report the use of stretchable styrene‐ethylene‐butylene‐styrene (SEBS) fibers as a conductive substrate to simultaneously load Au nanowire and Prussian blue (PB) as biosensing interfaces. Accordingly, due to the synergistic catalytic effect between Au nanowire and Prussian blue, the as‐obtained flexible PB/Au fibers can not only show the potential as wearable biosensors but also serve as high‐performance peroxidase‐like nanozymes. The functional fibers can be used for colorimetric detection of H2O2 and uric acid, exhibiting satisfactory sensitivity and selectivity in serum sample analysis. The flexible PB/Au fibers represent a new form of Peroxidase‐like nanozymes, which could open doors to various wearable biosensing applications.
Multidimensional Co3O4/NiO heterojunctions with rich‐boundaries incorporated into reduced graphene oxide network for expanding the range of lithiophilic host
Authors: Meng Qianqian , Guan Minrong , Huang Yongxin , Li Li , Wu Feng , Chen Renjie 
Published: April 2022

AbstractThe commercial application of lithium (Li) metal anode is hindered by the growth of Li dendrites. Here, we develop a multidimensional composite structure composed of Co3O4/NiO heterojunction particles and reduced graphene oxide (rGO) nanosheets, that allows Li to nucleate and deposit selectively in one direction. Among, two transition metal oxides (TMOs) without lithiophilicity are transformed into lithiophilic species due to the rich phase boundaries and high Li adsorption energies on interfaces, which can provide uniform active sites and reduce nucleation overpotential for Li deposition. Meanwhile, the rGO substrate with high electrical conductivity and large specific surface area can form a conductive network between TMOs and alleviate volume expansion caused by Li deposition. Benefitting from the synergistic effect of the heterojunctions and carbon substrate, the Co3O4/NiO‐rGO regulates the local current density and enables the dendrite‐free Li plating/stripping behavior. At a current density of 1 mA cm−2, the Li metal anode with the Co3O4/NiO‐rGO host exhibits remarkable electrochemical performance, consistently maintaining high Coulombic efficiency (>93.8%) over 1000 cycles. Additionally, the full cells matched with LiFePO4 cathode also display high rate capability of 130 mAh g−1 at 1 C and stable cycling life over 500 cycles.
image