bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and antibacterial against Staphylococcus aureus of new ruthenium (II) polypyridine complexes containing pyrene groups
Authors: Ma Yuanyuan , Wei Ming , Wang Xuerong , Jiang Li , Xiong Yanshi , Cheng Jianxin , Tan Yanhui , Liao Xiangwen , Wang Jintao 
Published: August 2022

AbstractAs the treatment of Staphylococcus aureus infection becomes more and more difficult, it is particularly important to develop new antibacterial agents against S. aureus infection. Herein, three ruthenium (II) complexes containing pyrene groups, [Ru (bpy)2(PYIP)](PF6)2 (Ru‐1), [Ru (dtbpy)2(PYIP)](PF6)2 (Ru‐2), and [Ru (ttbpy)2(PYIP)](PF6)2 (Ru‐3) (PYIP = 2‐(pyren‐1‐yl‐1H‐imidazo[4,5‐f][1,10]phenanthroline, bpy = 2,2′‐bipyridine, dtbpy = 4,4′‐dimethyl‐2,2′‐bipyridine and ttbpy = 4,4′‐di‐tert‐butyl‐2,2′‐bipyridine) were designed and synthesized. The antibacterial activities of them against S. aureus were evaluated by determining the minimum inhibitory concentration and minimum bactericidal concentration. The results showed that three ruthenium complexes had excellent antibacterial activities against S. aureus. Among them, Ru‐2 exhibited the best bacteriostatic concentration and bactericidal activities, which was selected for the further antibacterial mechanism exploring. Ru‐2 can obviously inhibit the growth of bacterial biofilm, and the drug resistance results showed that Ru‐2 can effectively prevent the development of bacterial resistance. Moreover, the in vivo antibacterial activity of Ru‐2 was evaluated by establishing mouse infection model with the results that Ru‐2 could effectively inhibit the growth of bacteria and make mouse wounds heal faster.
Comparative treatment costs of risk‐stratified therapy for childhood acute lymphoblastic leukemia in India
Authors: Mungle Tushar , Das Nandana , Pal Saikat , Gogoi Manash Pratim , Das Parag , Ghara Niharendu , Ghosh Debjani , Arora Ramandeep Singh , Bhakta Nickhill , Saha Vaskar , Krishnan Shekhar 
Published: August 2022

AbstractBackgroundTo evaluate the treatment cost and cost effectiveness of a risk‐stratified therapy to treat pediatric acute lymphoblastic leukemia (ALL) in India.MethodsThe cost of total treatment duration was calculated for a retrospective cohort of ALL children treated at a tertiary care facility. Children were risk stratified into standard (SR), intermediate (IR) and high (HR) for B‐cell precursor ALL, and T‐ALL. Cost of therapy was obtained from the hospital electronic billing systems and details of outpatient (OP) and inpatient (IP) from electronic medical records. Cost effectiveness was calculated in disability‐adjusted life years.ResultsOne hundred and forty five patients, SR (50), IR (36), HR (39), and T‐ALL (20) were analyzed. Median cost of the entire treatment for SR, IR, HR, and T‐ALL was found to be $3900, $5500, $7400, and $8700, respectively, with chemotherapy contributing to 25%–35% of total cost. Out‐patient costs were significantly lower for SR (p < 0.0001). OP costs were higher than in‐patient costs for SR and IR, while in‐patient costs were higher in T‐ALL. Costs for non‐therapy admissions were significantly higher in HR and T‐ALL (p < 0.0001), representing over 50% of costs of in‐patient therapy. HR and T‐ALL also had longer durations of non‐therapy admissions. Based on WHO‐CHOICE guidelines, the risk‐stratified approach was very cost effective for all categories of patients.ConclusionsRisk‐stratified approach to treat childhood ALL is very cost‐effective for all categories in our setting. The cost for SR and IR patients is significantly reduced through decreased IP admissions for both, chemotherapy and non‐chemotherapy reasons.
Interactive texture editing for garment line drawings
Authors: Fukusato Tsukasa , Shibata Ryohei , Noh Seung‐Tak , Igarashi Takeo 
Published: August 2022

AbstractAdding two‐dimensional (2D) textures to garment line drawings (e.g., cartoon characters) remains challenging in the production pipeline of comics and illustrations since garment line drawings often have self‐occluded wrinkles. Although several techniques that can automatically deform and map 2D texture patterns to 2D line drawings have been proposed, their qualities are insufficient for representing 3D‐like realistic garment designs and manual editing of UV coordinates, which is labor‐intensive. In this article, we introduce an interactive tool to efficiently edit UV coordinates of 2D garment line drawings on the modeling panel with curve and point handles. Our algorithm is simple to integrate into existing image authoring tools. We conduct a user study with novice users and confirm that the proposed tool can effectively handle texture mapping envisioned by the users.
Applications of the ultrasound‐guided nerve block technique for nonanalgesic effects
Authors: Zhang Guang‐Ting , Wang Feng‐Lin , Ran Ying , Liu De‐Xing 
Published: August 2022

AbstractThe nerve block technique guided by ultrasound has been able to accurately block tiny nerves throughout the body in recent years. It has been increasingly used to treat multisystem diseases or analgesia in surgical patients, but the latter accounted for the vast majority of cases. The nonanalgesic effect of nerve blocks is also in wide demand. After searching ultrasound‐guided nerve block works on the PubMed database, we systematically summarized the current clinical application of the nerve block technique and the unique role and related mechanism of nerve block in the prevention and treatment of multi‐system diseases or symptoms, including disorders of the circulatory and respiratory systems, postoperative cognitive dysfunction, immune function, posttraumatic stress disorder, and postoperative digestive system, to put forward the potential prospective application in future and serve as a reference for future research of nerve block therapy in these diseases mentioned.
TCM‐Suite: A comprehensive and holistic platform for Traditional Chinese Medicine component identification and network pharmacology analysis
Authors: Yang Pengshuo , Lang Jidong , Li Hongjun , Lu Jinxiang , Lin Hanyang , Tian Geng , Bai Hong , Yang Jialiang , Ning Kang 
Published: August 2022

AbstractDNA‐based biological ingredient identification and downstream pharmacology network analysis are commonly used in research for Traditional Chinese Medicine preparations (TCM formulas). Advancements in bioinformatics tools and the accumulation of related data have become driving forces for progress in this field. However, a lack of a platform integrating biological ingredient identification and downstream pharmacology network analysis hinders the deep understanding of TCM. In this study, we developed the TCM‐Suite platform composed of two sub‐databases, Holmes‐Suite and Watson‐Suite, for TCM biological ingredient identification and network pharmacology investigation, respectively, both are among the most complete: In the Holmes‐Suite, we collected and processed six types of marker gene sequences, accounting for 1,251,548 marker gene sequences. In the Watson‐Suite, we curated and integrated a massive number of entries from more than 10 public databases. Importantly, we developed a comprehensive pipeline to integrate TCM biological ingredient identification and downstream network pharmacology research, allowing users to simultaneously identify components of a TCM formula and analyze its potential pharmacology mechanism. Furthermore, we designed search engines and a user‐friendly platform to better search and visualize these rich resources. TCM‐Suite is a comprehensive and holistic platform for TCM‐based drug discovery and repurposing. TCM‐Suite website: http://TCM-Suite.AImicrobiome.cn.
Consistency analysis of the Sysmex UF‐5000 and Atellica UAS 800 urine sedimentation analyzers
Authors: Liu Hai , Li Qing , Zhang Yiduo , Huang Dongyue , Yu Fan 
Published: August 2022

AbstractObjectiveTo evaluate the consistency between the results of Sysmex UF‐5000 system and Atellica® UAS 800 Urine Sediment Analyzer.MethodsA total of 636 random urine samples were collected from inpatients and outpatients from March to September 2021. Urine was collected for analysis by the Sysmex UF‐5000, Atellica UAS 800 systems, and manual microscopic examination. The results of manual microscopy as the gold standard, the coincidence rate and false‐negative rate of Sysmex UF‐5000 and Atellica UAS 800 systems in the detection of red blood cells, white blood cells, and casts were calculated.ResultsThe coincidence rates of red blood cells, white blood cells, and cast, crystals, and other sediment components for the Sysmex UF‐5000 system were 85.37%, 87.89%, 91.67%, 88.36%, and 71.86%. The false‐negative rates were 28.47%, 3.75%, 68.97%, 37.25%, and 30.63%. The coincidence rates of red blood cells, white blood cells, and cast, crystals, and other sediment components for the Atellica UAS 800 system were 85.06%, 90.25%, 59.12%, 91.67%, and 67.45% and the false‐negative rates were 60.42%, 21.25%, 36.21%, 19.64%, and 35.80%.ConclusionTwo instruments are superior in the detection of red blood cells and white blood cells. The Atellica UAS 800 system with image review has a good coincidence rate in the identification of crystals and casts. The identification of various sediment components in urine by both instruments meets the laboratory requirements. Two instruments with different methodologies have their own characteristics, and we should reasonably use them according to the conditions of the laboratory.
Decadal trends in soil and grain microelement concentrations indicate mainly favourable development in Finland
Authors: Soinne Helena , Kurkilahti Mika , Heikkinen Jaakko , Eurola Merja , Uusitalo Risto , Nuutinen Visa , Keskinen Riikka 
Published: August 2022

AbstractBackgroundObservations on declining nutrient contents in crops have raised concerns about soil fertility and food quality. Long‐term monitoring data are valuable in exposing trends and indicating the need for interventions.AimsThis study aimed to assess the soil microelement status and grain nutritional value on a national scale in Finland over the last decades.MethodsUsing nationwide sets of samples and time‐series datasets, temporal trends in readily available zinc, copper, boron, iron, manganese, cadmium, molybdenum, nickel, aluminium, cobalt, and lead in cultivated soils of Finland during 1974–2018 and the corresponding total element concentrations in grains of oats and barley during 1988–2019 were determined.ResultsIn soil, initially increasing trends of element concentrations tended to prevalently level off towards the end of the study period. A decreasing trend was observed only for cadmium and zinc in coarse soils. In grains of barley and oat, aluminium and lead concentrations decreased between 1988 and 2019. Barley grains exhibited a decreasing trend in manganese and cobalt, whereas an increasing trend was detected for copper and iron in oats.ConclusionsNo alarming decreases in micronutrient contents in agricultural soils or cereal grains were detected over the study period. In grains, the concentrations of potentially toxic elements decreased. Although the nationwide micronutrient status in Finland is on average satisfactory or good, local micronutrient deficiencies may occur.
One‐Step Synthesis of Dynamically Shaped Stiff Nanorods Using Soft Silicone Materials to Control Water Repulsion and Collection
Authors: Chen Kangwei , Liu Shanqiu , Lau Yuen‐Yee , Seeger Stefan 
Published: August 2022

AbstractOne‐dimensional silicone nanostructures, such as filaments, wires, and tubes, have attracted significant attention, owing to their remarkable application capabilities in a large range of material and surface science. However, the soft mechanical properties of silicone cause vulnerability and irregularity in the synthesized structures, which limits their applications. Herein, a simple, solvent‐free, and efficient dynamic Droplet Assisted Growth and Shaping (d‐DAGS) strategy is proposed for the one‐step synthesis and in situ control of the shape of silicone nanostructures. The special designed bamboo‐shaped silicone nanorods (SNRs) that are produced by the repetitive dynamic regulation of growth conditions, concomitant with the periodic purging and injection of precursors, exhibit highly‐regular and tunable structure with a specific number of segments, indicating that they can be tailor‐made according to the requirements of various properties. The enhanced mechanical stiffness and chemical durability strongly support their excellent performances in water‐resistance under both static and dynamic wetting conditions. The SNRs significantly promote buoyancy and self‐cleaning properties; and exhibit very high water‐harvesting efficiency compared with existing designs. Notably, the well‐structured ultra‐long rods with an ultrahigh aspect ratio (≈176) can also be fabricated by the d‐DAGS method, and they can remain standing straight upwards and regular, even though they consist of flexible silicone.
DNA as in‐formation
Authors: Kaufmann Mareile 
Published: August 2022

AbstractTraces are fundamental vectors of information. This is the first of seven forensic principles formulated by the 2022 Sydney declaration. To better understand the trace as information, this article proposes the notion of in‐formation. DNA is matter in becoming. DNA changes as it travels across forensic sites and domains. New formations occur as humans, technologies and DNA interact. Understanding DNA as in‐formation is of particular relevance vis‐à‐vis the increase of algorithmic technologies in the forensic sciences and the rendering of DNA into (big) data. The concept can help identifying, acknowledging and communicating those moments of techno‐scientific interaction that require discretion and methodical decisions. It can assist in tracing what form DNA will take and what consequences this may have.This article is categorized under:
Crime Scene Investigation > From Traces to Intelligence and Evidence
Forensic Biology > Ethical and Social Implications
Forensic Biology > Forensic DNA Technologies
Empowering users to control ads and its effects on website stickiness
Authors: Werner Dominick , Adam Martin , Benlian Alexander 
Published: August 2022

AbstractWebsite providers find it increasingly difficult to convince users to accept advertisements (ads) on their websites. In this study, we investigate ad quantity customization (AQC) as a practice to counter these challenges. AQC refers to the technological means through which website providers enable users to determine the amount of ads displayed on their websites. Drawing on psychological empowerment theory, we demonstrate in an online experiment with 395 participants that AQC can pay off: A website with AQC elicits significantly higher website stickiness than a website without AQC, even if the website without AQC contains no ads at all. We furthermore find that perceived empowerment, informational fit-to-task and perceived enjoyment mediate the effect of AQC on website stickiness. Our study thus contributes to Information Systems research on web customization and offers website providers actionable recommendations to keep their users involved, interested and retained.
Mud pumping in high-speed railway: in-situ soil core test and full-scale model testing
Authors: Wan Zhangbo , Bian Xuecheng , Chen Yunmin 
Published: August 2022

AbstractMud pumping induced by moving train loads on rainwater-intruded roadbed causes intensive track vibrations and threatens safety of high-speed trains. In this paper, a vehicle–track–subgrade finite element model was established to analyze the dynamic responses of a ballastless track, and results showed that the concrete base and roadbed were detached because of the whipping effect arising from the rainwater intrusion channel. An in-situ soil core test showed that the intruded rainwater accumulated in roadbed to form standing water and saturated the roadbed. The flapping action of the concrete base caused by the whipping effect led to mud formation mixed with fine particles and rainwater, which migrated upward under the pore-water pressure (PWP) gradient. Mud pumping resulted from continuous particle migration in the saturated roadbed under moving train loads: under normal roadbed condition, coarse and fine particles were uniformly distributed in the roadbed; in early period of mud pumping, fine particles migrated downward to bottom of the roadbed because of the rainwater infiltration flow; in middle stage of mud pumping, fine particles migrated upward and gathered at the roadbed surface under PWP gradient; in later period of mud pumping, fine particles were entrained and removed with the dissipation of excess PWP. Moreover, a full-scale physical model was established to reproduce mud pumping, and polyurethane injection remediation against mud pumping was validated on this physical model. The remediation method was applied to an in-situ mud pumping. The deviation of the vertical track profile reduced remarkably and remained at a low level within half a year, showing a good long-term service performance of the polyurethane remediated roadbed.
Connecting Hodge and Sakaguchi-Kuramoto through a mathematical framework for coupled oscillators on simplicial complexes
Authors: Arnaudon Alexis , Peach Robert L. , Petri Giovanni , Expert Paul 
Published: August 2022

AbstractPhase synchronizations in models of coupled oscillators such as the Kuramoto model have been widely studied with pairwise couplings on arbitrary topologies, showing many unexpected dynamical behaviors. Here, based on a recent formulation the Kuramoto model on weighted simplicial complexes with phases supported on simplices of any order k, we introduce linear and non-linear frustration terms independent of the orientation of the k + 1 simplices, as a natural generalization of the Sakaguchi-Kuramoto model to simplicial complexes. With increasingly complex simplicial complexes, we study the the dynamics of the edge simplicial Sakaguchi-Kuramoto model with nonlinear frustration to highlight the complexity of emerging dynamical behaviors. We discover various dynamical phenomena, such as the partial loss of synchronization in subspaces aligned with the Hodge subspaces and the emergence of simplicial phase re-locking in regimes of high frustration.
Non-resonant exceptional points as enablers of noise-resilient sensors
Authors: Tuxbury William , Kononchuk Rodion , Kottos Tsampikos 
Published: August 2022

AbstractExceptional point degeneracies (EPDs) in the resonant spectrum of non-Hermitian systems have been recently employed for sensing due to the sublinear response of the resonance splitting when a perturbant interacts with the sensor. The sublinear response provides high sensitivity to small perturbations and a large dynamic range. However, the resonant-based EPD sensing abides to the resolution limit imposed by the resonant quality factors and by the signal-to-noise ratio reduction due to gain-elements. Moreover, it is susceptible to local mechanical disturbances and imperfections. Here, we propose a passive non-resonant (NR) EPD-sensor that is resilient to losses, local cavity variations, and noise. The NR-EPD describes the coalescence of Bloch eigenmodes associated with the spectrum of transfer matrices of periodic structures. This coalescence enables scattering cross-section cusps with a sublinear response to small detunings away from an NR-EPD. We show that these cusps can be utilized for enhanced noise-resilient sensing.
Nigerian English as a Lingua Franca
Authors: Müller Julia , Mair Christian 
Published: August 2022

Abstract
This paper investigates the use of Nigerian English in lingua-franca interaction in Germany, focussing on the perspective of the German listener. Fifty-eight German-speaking respondents were asked to transcribe short extracts from English interviews recorded with Nigerian immigrants and sojourners resident in Germany. In addition to testing comprehension, respondents were requested to rate samples along parameters designed to measure speaker likability and competence. The study’s two major findings are that, in spite of the absence of contextual clues, respondents perform better than expected in the comprehension task, but that the single greatest obstacle to comprehension is the presence of German-language material in the stimulus. As realistic English as a Lingua Franca (ELF) interaction in Germany necessarily involves a level of English-German mixing, the experiment thus points to a major practical problem in ELF interaction. The study also yields provisional findings on gender (with male voices being understood better than female ones) and interactions between assumptions about speakers and transcription performance that should be revisited in future research.
Feeling for speaking
Authors: Müller Cornelia , Marienfeld Benjamin 
Published: August 2022

Abstract
In this paper, attention is drawn to the embodied experiences that are mobilized when speakers are
asked to describe emotions. By analyzing how people use expressive body movements and language when thinking
and speaking about emotion concepts, light is thrown on “People’s subjective, felt experiences of their
bodies in action” (Gibbs, 2005: 9). It illustrates how experiencing emotion
concepts bodily provides “part of the fundamental grounding for language and thought.” (Gibbs, 2005: 9). The title of this chapter alludes to Daniel I. Slobin’s reformulation of the
linguistic relativity hypothesis. Slobin counters Wilhelm von Humboldt and Benjamin L. Whorf
static understanding of the relationship between “thought and language” with a dynamic idea of this relation which he
terms Thinking for speaking (Slobin, 1996: 76). We report
a small study indicating that speakers not only express affective experiences as conceptual content, but perform or
indicate expressive body movements before or while describing a specific emotion. The chapter thus suggests a very
concrete way of understanding Gibbs’ assumption of an “embodiment premise for language and thought”.
Defaultness vs. constructionism
Authors: Giora Rachel 
Published: August 2022

Abstract
Default responses play a major role in affecting processing, pleasantness, and cueing of
nondefault alternatives. Default responses are activated automatically, initially and directly, faster than nondefault
counterparts, irrespective of degree of negation, novelty, nonliteralness, or contextual support (Giora et al., 2015c). No wonder default automatic responses may be initially
involved in processing nondefault counterparts. This involvement of defaultness in processing nondefaultness slows
down the latter while rendering it Optimal Innovative and therefore pleasing, even if highly dependent on context or
cueing for its derivation. Findings here are discussed in terms of the Defaultness Hypothesis (Giora et al., 2015c, 2017), Construction Grammar
(e.g., Goldberg, 1995, 1996,
2006, 2013; Johnson & Goldberg, 2013), and pragmatic effects.