bluuebunny/crossref_metadata_2025_split huggingface dataset:
LSTM and CNN application for core-collapse supernova search in gravitational wave real data
Authors: Iess Alberto , Cuoco Elena , Morawski Filip , Nicolaou Constantina , Lahav Ofer 
Published: September 2022

Context.Core-collapse supernovae (CCSNe) are expected to emit gravitational wave signals that could be detected by current and future generation interferometers within the Milky Way and nearby galaxies. The stochastic nature of the signal arising from CCSNe requires alternative detection methods to matched filtering.Aims.We aim to show the potential of machine learning (ML) for multi-label classification of different CCSNe simulated signals and noise transients using real data. We compared the performance of 1D and 2D convolutional neural networks (CNNs) on single and multiple detector data. For the first time, we tested multi-label classification also with long short-term memory (LSTM) networks.Methods.We applied a search and classification procedure for CCSNe signals, using an event trigger generator, the Wavelet Detection Filter (WDF), coupled with ML. We used time series and time-frequency representations of the data as inputs to the ML models. To compute classification accuracies, we simultaneously injected, at detectable distance of 1 kpc, CCSN waveforms, obtained from recent hydrodynamical simulations of neutrino-driven core-collapse, onto interferometer noise from the O2 LIGO and Virgo science run.Results.We compared the performance of the three models on single detector data. We then merged the output of the models for single detector classification of noise and astrophysical transients, obtaining overall accuracies for LIGO (~99%) and (~80%) for Virgo. We extended our analysis to the multi-detector case using triggers coincident among the three ITFs and achieved an accuracy of ~98%.
Clinical Concerns on Sex Steroids Variability in Cisgender and Transgender Women Athletes
Authors: Di Luigi Luigi , Greco Emanuela A , Fossati Chiara , Aversa Antonio , Sgrò Paolo , Antinozzi Cristina 
Published: September 2022

AbstractIn the female athletic community, there are several endogenous and exogenous variables that influence the status of the hypothalamus-pituitary-ovarian axis and serum sex steroid hormones concentrations (e. g., 17β-estradiol, progesterone, androgens) and their effects. Moreover, female athletes with different sex chromosome abnormalities exist (e. g., 46XX, 46XY, and mosaicism). Due to the high variability of sex steroid hormones serum concentrations and responsiveness, female athletes may have different intra- and inter-individual biological and functional characteristics, health conditions, and sports-related health risks that can influence sports performance and eligibility. Consequently, biological, functional, and/or sex steroid differences may exist in the same and in between 46XX female athletes (e. g., ovarian rhythms, treated or untreated hypogonadism and hyperandrogenism), between 46XX and 46XY female athletes (e. g., treated or untreated hyperandrogenism/disorders of sexual differentiation), and between transgender women and eugonadal cisgender athletes. From a healthcare perspective, dedicated physicians need awareness, knowledge, and an understanding of sex steroid hormones’ variability and related health concerns in female athletes to support physiologically healthy, safe, fair, and inclusive sports participation. In this narrative overview, we focus on the main clinical relationships between hypothalamus-pituitary-ovarian axis function, endogenous sex steroids and health status, health risks, and sports performance in the heterogeneous female athletic community.
Epidemiology of injuries in elite Korean adolescent football (soccer)
athletes: A prospective cohort study
Authors: Kim June chul , Park Ki Jun 
Published: September 2022

Abstrct
Objectives This study attempted to analyze the injury patterns during
training by sex and determine whether cardiopulmonary function and bone mineral
density (BMD) were related to the patterns of injuries in elite adolescent
footballers.
Methods Since 2021, data for consisted of 96 adolescent football athletes
(52 men and 44 women) who underwent intensive training in Korea and participated
in competitions. For cardiopulmonary function, minute ventilation (VE), volume
oxygen maximum (VO2max), and ventilation threshold (VT) were measured. BMD was
measured measure systemic BMD and bone mass. The injury incidence rates (IIR)
per 1000 training of hours. χ2 tests were performed to compare injury
patterns between sex. Simple linear regression was used to evaluate the
relationship between variables.
Results The overall IIR was 4.80 (4.32–5.32) per 1000 h of
training. Female had a higher rate than male (p=0.008). We observed
differences in injury severity between men and women (p=0.040). Both the
cardiopulmonary function and BMD were related to IIR in all athletes. The body
regions with the most injuries were the lower extremities (52.05%),
trunk (23.84%), upper extremities (16.71%), and head and neck
(7.40%). Cardiopulmonary function and BMD were not related to the
location of the injury. However, Cardiopulmonary function and BMD were related
to the IIR of severe and ligament injury.
Conclusion The sex was found to affect rate and severity of injury.
Cardiopulmonary function and BMD were related to the injury patterns. Our
findings can help promote the performance improvement of elite football athletes
and the development of injury prevention program.
Both Amide-Bearing α- and β-Amino Acids from Natural Aspartic Acid Are Efficient Organocatalysts for Enantioselective Aldol Reactions
Authors: Wen Gen-Fa , Zhang Rui , Da Chao-Shan , Zhang Chu-Yu 
Published: September 2022

AbstractThis work aims to compare and explore the different catalytic efficiencies of structurally similar α- and β-amino acids in an asymmetric aldol transformation. Interestingly, aspartic acid is not only an α-amino acid, but also a β-amino acid. Thus, by modifying one of the two acidic groups of aspartic acid, two sets of α- and β-amino acids, 14 amino acids in total, were prepared and used as organocatalysts. The two types of amino acid, interestingly, achieved similar high catalytic efficiencies in the asymmetric aldol transformation under different optimal conditions. The ideal β-amino acid, in some cases, even achieved significantly higher enantioselectivity than the ideal α-amino acid, although α-amino acids are extensively demonstrated to be highly efficient organocatalysts in this asymmetric transformation.
Reducing care time after implementing protocols for acute ischemic stroke: a systematic review
Authors: Leite Karina Fonseca de Souza , dos Santos Samuel Ribeiro , Andrade Rubia Laine de Paula , de Faria Mariana Gaspar Botelho Funari , Saita Nanci Michele , Arcêncio Ricardo Alexandre , Isaac Igor Simões da Silva , de Rezende Carlos Eduardo Menezes , Villa Tereza Cristina Scatena , Pontes Neto Octavio Marques , Monroe Aline Aparecida 
Published: September 2022

Abstract
Background The treatment of acute ischemic stroke with cerebral reperfusion therapy requires rapid care and recognition of symptoms.
Objective To analyze the effectiveness of implementing protocols for acute ischemic stroke in reducing care time.
Methods Systematic review, which was performed with primary studies in Portuguese, English, and Spanish published between 2011 and 2020. Inclusion criteria: study population should comprise people with acute ischemic stroke and studies should present results on the effectiveness of using urgent care protocols in reducing care time. The bibliographic search was conducted in June 2020 in the LILACS, MEDLINE, Embase, Scopus, CINAHL, Academic Search Premier, and SocINDEX databases. The articles were selected, and data were extracted by two independent reviewers; the synthesis of the results was performed narratively. The methodological quality of articles was evaluated through specific instruments proposed by the Joanna Briggs Institute.
Results A total of 11,226 publications were found, of which 35 were included in the study. Only one study reported improvement in the symptoms-onset-to-door time after protocol implementation. The effectiveness of the therapeutic approach protocols for ischemic stroke was identified in improving door-to-image, image-to-needle, door-to-needle and symptoms-onset-to-needle times. The main limitation found in the articles concerned the lack of clarity in relation to the study population.
Conclusions Several advances have been identified in in-hospital care with protocol implementation; however, it is necessary to improve the recognition time of stroke symptoms among those who have the first contact with the person affected by the stroke and among the professionals involved with the prehospital care.
Misdiagnoses in a Brazilian population with amyotrophic lateral sclerosis
Authors: Borghetti Vinicius Stefani , Cintra Vívian Pedigone , Ramos Jean de Oliveira , Marques Vanessa Daccach , Onofre Patrícia Toscano , Santana Victor Augusto Souza , Bezerra Lua Flora Pereira , Tomaselli Pedro José , Santos André Cleriston José dos , Sobreira Claudia Ferreira da Rosa , Marques Jr Wilson 
Published: September 2022

AbstractBackground Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects the upper and lower motor neurons. The correct diagnosis at the onset of the disease is sometimes very difficult, due to the symptoms being very similar to those of other neurological syndromes.Objective This study aimed to analyze the initial manifestations, the specialty of the first physician visited due the initial complaint, the misdiagnoses, as well as the unnecessary surgical interventions in a new ALS Brazilian population.Methods The medical records of 173 patients with typical ALS were reviewed.Results The present study demonstrated that other symptoms, besides weakness, were very frequent as initial presentation of ALS, and orthopedics was the medical specialty most sought by patients at the onset of symptoms. Our frequency of misdiagnoses was 69.7%, and in 7.1% of them, an unnecessary surgical intervention was performed.Conclusions Amyotrophic lateral sclerosis presents a very large pool of signs and symptoms; therefore, there is an urgent need of increasing the disease awareness to other specialties due to the high frequency of misdiagnoses observed in clinical practice.
Autonomic and cardiorespiratory responses to the active tilt test in individuals with Parkinson disease: cross-sectional study
Authors: Valente Heloisa Balotari , Gervazoni Natacha de Lima , Laurino Maria Júlia Lopez , Vanzella Laís Manata , Stoco-Oliveira Mileide Cristina , Rodrigues Mariana Viana , André Larissa Borba , Ribeiro Felipe , Carvalho Augusto Cesinando de , Vanderlei Luiz Carlos Marques 
Published: September 2022

Abstract
Background The Parkinson disease (PD) is frequently associated with autonomic dysfunctions. However, data regarding the influence of PD on the autonomic responses to postural changes is limited.
Objective To analyze and compare the autonomic responses, evaluated through linear and non-linear methods of heart rate variability, and cardiorespiratory parameters in two groups: Parkinson disease (PDG) and control (CG), at rest and during the active tilt test.
Methods A total of 48 participants were analyzed (PDG: n = 25;73.40 ± 7.01 years / CG: n = 23;70.17 ± 8.20 years). The autonomic modulation and cardiorespiratory parameters were evaluated at rest and during the active tilt test. To assess the autonomic modulation the linear indices, at the time (rMSSD, SDNN) and frequency (LF, HF, LF/HF) domains, and the non-linear indices, obtained through the Poincaré plot (SD1, SD2, SD1/SD2), were calculated. The cardiorespiratory parameters evaluated were heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP), peripheral oxygen saturation (SpO2), and respiratory rate.
Results At rest, the PDG presented significantly lower values of rMSSD, SDNN, LF, HF, SD1, SD2, and DBP, and higher values of SpO2. During test, in the PD group, modifications were observed in HR, and SBP, besides a reduced parasympathetic response, and an increased global modulation. The qualitative analysis of the Poincaré plot showed that the PDG has a lower dispersion of the RR intervals during rest and the active tilt test.
Conclusion Individuals with PD present reduced global variability and parasympathetic modulation at rest, and reduced parasympathetic response and damage in HR regulation when performing the active tilt test, compared with controls.
I would be better off dead: investigating suicidal ideation in people with epilepsy
Authors: Tedrus Gloria Maria de Almeida Souza , Souza Daniela de Carvalho Mendonça de 
Published: September 2022

AbstractBackground It is known that the risk of suicidal behavior in adult people with epilepsy (PWEs) is high. However, the associated clinical and psychosocial factors are still being discussed.Objective To assess the risk of suicide in PWEs and relate it to resilience and quality of life (QoL) as well as with clinical variables.Methods The item “I'd be better off dead” of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) was related to the resilience scale, clinical aspects, the presence of depression, and the Quality of Life in Epilepsy Inventory (QOLIE-31) scores of PWEs, with a p < 0.05.Results A total of 271 PWEs were assessed, 50.6% were female, with a mean age of 46.6 (± 15.8) years, and a mean age at 1st seizure of 24.1 (± 18.5) years. Risk for suicide occurred in 50 (19.3%) cases. In multiple logistic regression, the factors that explain the risk of suicide were female sex, depression, and lower scores on the QOLIE-31 and on the resilience scale. In the classification and regression trees, the order of importance of the variables was depression > resilience > age > QoL > age at 1st seizure.Conclusion The risk of suicide was high, and it was associated with demographic aspects, clinical variables, QoL, and resilience. A higher risk of suicide was associated with lower resilience regardless of the presence or absence of depression. In the presence of depression, a higher risk of suicide was associated with the early onset of epilepsy. In the absence of depression, the risk of suicide was associated with low QoL in young adults.
Neuromuscular diseases and social distance resulting from the COVID-19 pandemic
Authors: Maciel Flaviana Kelly de Lima , Grossklauss Luis Fernando , Favero Francis Meire , Sá Cristina dos Santos Cardoso de 
Published: September 2022

Abstract
Background Coronavirus 2 severe acute respiratory syndrome (SARS-CoV-2), generically called COVID-2019, classified as a pandemic by the World Health Organization, has made health practices around the world face unique challenges. Since then, physical distancing and measures such as confinement have been adopted by different governments to control human-to-human transmission. This distance affected the treatment of individuals with progressive diseases such as neuromuscular diseases (NMDs).
Objective To identify how patients with NMDs performed the therapeutic routine during social distancing and confinement resulting from the COVID-19 pandemic.
Methods Application of a questionnaire prepared in the Google forms application, whose link for access and participation was sent by email or WhatssApp for family members and/or individuals with DNMs to respond. The questionnaire consisted of multiple-choice questions, divided into the following sections: personal data, treatments performed before and during the pandemic, activities performed during confinement, and characterization of motor function in activities of daily living comprising the period between September and October 2020.
Results We observed a significant reduction in medical appointments for patients with NMDs. On the other hand, the results showed that most patients underwent motor and/or respiratory physiotherapy in person or by telemonitoring. The study participants reported spending more time playing indoors, and all pointed out motor changes during social distancing.
Conclusion There were changes in the therapeutic routine of patients with NMDs during the period of social distancing due to COVID-19.
Predictors of functional communication in people with aphasia after stroke
Authors: Fernandes Adriana , Fraga-Maia Helena , Maso Iara , Matos Isabela Guimarães , Gomes Lene , Matos Matheus , Santana Andressa , Oliveira-Filho Jamary , Jesus Pedro Antônio de , Pinto Elen Beatriz 
Published: September 2022

Abstract
Background Aphasia, the most common language disorder secondary to stroke, has been associated with increased mortality, longer hospitalization and rehabilitation times, worse performance in daily activities, increased financial burden, and short- and long-term complications. Aphasia can negatively impact functional communication skills, including social networks, social activities, relationships with other people and social support.
Objective To evaluate patients with poststroke aphasia in their respective residences to investigate potential predictors of functional communication.
Methods The prospective cohort included patients with poststroke aphasia aged 18 years or older who resided in the city of Salvador, Northeastern Brazil. Following discharge from the Stroke Unit (SU), the individuals themselves, or their guardians, were contacted by telephone to schedule a home visit no less than three months after discharge. At baseline, sociodemographic and clinical data were collected, in addition to the scores on the National Institutes of Health Stroke Scale (NIHSS) and modified Barthel Index (mBI). The American Speech-Language-Hearing Association Functional Assessment of Communication Skills for Adults (ASHA FACS) was applied at the patients' homes. Multivariate linear regression was employed using the total score on the ASHA FACS as the outcome of interest.
Results A multivariate analysis of the associated factors identified using the linear regression revealed that only functional capacity (as assessed by the mBI) upon discharge from the SU remained as an independent predictor of functional communication performance (β = 0.042; 95% confidence interval [95%CI] = 0.013–0.071; p = 0.002).
Conclusion The functional capacity to perform daily activities, evaluated upon discharge from a stroke unit, was identified as a potential predictor of functional communication performance, regardless of the time elapsed after the stroke.
Brain volume loss and physical and cognitive impairment in naive multiple sclerosis patients treated with fingolimod: prospective cohort study in Buenos Aires, Argentina
Authors: Rojas Juan Ignacio , Patrucco Liliana , Pappolla Agustín , Sánchez Francisco , Cristiano Edgardo 
Published: September 2022

Abstract
Background The percentage of brain volume loss (PBVL) has been classically considered as a biomarker in multiple sclerosis (MS).
Objective The objective of the present study was to analyze if the PBVL during the 1st year after the onset of the disease predicts physical and cognitive impairment (CI).
Methods Prospective study that included naïve patients without cognitive impairment who initiated MS treatment with fingolimod. Patients were followed for 3 years and relapses, expanded disability status scale (EDSS) progression (defined as worsening of 1 point on the EDSS), the annual PBVL (evaluated by structural image evaluation using normalization of atrophy [SIENA]), and the presence of CI were evaluated. Cognitive impairment was defined in patients who scored at least 2 standard deviations (SDs) below controls on at least 2 domains. The PBVL after 1 year of treatment with fingolimod was used as an independent variable, while CI and EDSS progression at the 3rd year of follow-up as dependent variables.
Results A total of 71 patients were included, with a mean age of 35.4 ± 3 years old. At the 3rd year, 14% of the patients were classified as CI and 6.2% had EDSS progression. In the CI group, the PBVL during the 1st year was - 0.52 (±0.07) versus -0.42 (±0.04) in the no CI group (p < 0.01; odds ratio [OR] = 2.24; 95% confidence interval [CI]: 1.72–2.44). In the group that showed EDSS progression, the PBVL during the 1st year was - 0.59 (±0.05) versus - 0.42 (±0.03) (p < 0.01; OR = 2.33; 95%CI: 1.60–2.55).
Conclusions A higher PBVL during the 1st year in naïve MS patients was independently associated with a significant risk of CI and EDSS progression.
Thomas Willis' legacy on the 400th anniversary of his birth
Authors: Teive Hélio Afonso Ghizoni , Coutinho Léo , Camargo Carlos Henrique Ferreira , Munhoz Renato Puppi , Walusinski Olivier 
Published: September 2022

AbstractTo celebrate the 400th anniversary of the birth of Thomas Willis, his main contributions to the development of neurosciences, in particular neurology, are presented. Willis coined the term neurology and contributed significantly to the field of neuroanatomy, with the description of the arterial circle—located at the base of the brain—, which bears his name. He also described the striatum and cranial nerves. Furthermore, as a clinical neurologist, Willis participated in the description of various diseases, including myasthenia gravis and restless legs syndrome.
Role of Viscoelastic and Conventional Coagulation Tests for Management of Blood Product Replacement in the Bleeding Patient
Authors: Matkovic Eduard , Lindholm Paul F. 
Published: September 2022

AbstractAn important aim of viscoelastic testing (VET) is to implement transfusion algorithms based on coagulation test results to help reduce transfusion rates and improve patient outcomes. Establishing a rapid diagnosis and providing timely treatment of coagulopathy is the cornerstone of management of severely bleeding patients in trauma, postpartum hemorrhage, and major surgery. As the nature of acute bleeding and trauma leads to an unstable and tenuous physiologic state, conventional coagulation tests (CCTs) are too slow to diagnose, manage, and also course correct any hemostatic abnormalities that accompany an acute critical illness. Viscoelastic point-of-care tests strongly correlate with results from standard laboratory tests but are designed to enable clinicians to make timely, informed bleeding management decisions when time to intervene is critical. These assays provide an individualized and goal-oriented approach to patient blood management and are increasingly becoming involved in transfusion algorithms. The scope of this review aims to evaluate the current literature on VETs and their impact on actionable outputs in clinical decision making and their relationship to CCT.