bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of non-invasive brain stimulation on motor function after spinal cord injury: a systematic review and meta-analysis
Authors: Chen Jian-Min , Li Xiao-Lu , Yang Ye , Xu Sen-Ming , Xu Jian-Wen 
Published: September 2022

Abstract
Background: In recent years, non-invasive brain stimulation (NIBS) has often been used for therapeutic effects on motor functions. However, there is no clear evidence for the efficacy of NIBS in populations with spinal cord injury (SCI). This study aims to conduct a meta-analysis to summarize the existing evidence on the effectiveness and safety of NIBS for motor dysfunction after a spinal cord injury to obtain new insights.
Methods: Two investigators systematically screened English articles from PubMed, MEDLINE, Embase, and Cochrane Library for eligible Randomized and prospective controlled trials regarding the effects of NIBS in motor function recovery after SCI. Studies with at least three sessions of NIBS were included. We assessed the methodological quality of selected studies as described in the evidence-based Cochrane Collaboration’ tool. A meta-analysis of the motor function was performed by pooling thestandardized mean difference (SMD)with 95% confidence intervals (CI).
Results: A total of 14 studies involving 225 patients were included. Nine studies used repetitive transcranial magnetic stimulation (rTMS) and 5 studies used transcranial direct current stimulation (tDCS). The meta-analysis showed that NIBS could improve the lower extremity strength (SMD = 0.58, 95% CI= 0.02 to 1.14, P = 0.004), balance (SMD = 0.64, 95% CI= 0.05 to 1.24, P= 0.03) and decrees the spasticity (SMD = -0.64, 95% CI=-1.20 to-0.03, P =0.04); while functional mobility of the NIBS group was not statistically significant than that of the control group (upper extremity strength: P=0.07; spasticity: P=0.12). The motor function of upper extremity strength in the NIBS group did not reach statistical significance when compared with the sham group. Only one patient reported seizures occurred during stimulation; no other serious adverse events were reported.
Conclusion: NIBS appears to have a positive effect on motor function of the lower extremity in SCI patients. However, the marginal p-value and a high heterogeneity suggest that these results should be interpreted with caution. Further high-quality clinical trials are needed to support or refute the use and optimize the stimulation parameters of NIBS in clinical practice.
Evaluation of Corneal Tomographic, Densitometric, and Aberrometric Features Following Accelerated Corneal Cross-Linking in progressive keratoconus
Authors: Mohebbi Masoumeh , Samavat Bijan , Mohammadi Abbas 
Published: September 2022

Abstract
Purpose
To evaluate the 12 months' changes in tomographic, densitometric, and aberrometric parameters in keratoconic eyes after accelerated corneal cross-linking (CCL) and classify a densitometric course in different stages of the keratoconus separately (Mild, moderate, and severe).
Methods
In a prospective observational study, 67 keratoconic eyes of 67 patients that underwent accelerated epithelium-off corneal cross-linking (9 mW/cm2 and 10 minutes) for treatment of progressive keratoconus were included. Corneal tomographic, densitometric, and aberrometric values obtained using the Pentacam HR were recorded at the baseline and 3, 6, and 12 months post-operatively.
Result
One year after treatment, corrected distance visual acuity (CDVA) was improved, and maximum keratometry, thinnest pachymetry, higher order, and total Root Mean Square (RMS) were significantly decreased. (p < 0.001) Corneal densitometry values showed a significant elevation 3 months post-surgery compared to baseline and then decreases to baseline values at 1 year. Only the Anterior 0–2 mm zone densitometry at the third month was different between the three groups. RMS at 1 year correlated with Anterior 0–2 mm, Anterior 2–6 mm, total corneal 0–2 mm, and total corneal 2–6 mm densitometry values in the third month. Final CDVA at 12th-month follow-up correlated with the Anterior 0–2 mm corneal densitometry in the third month.
Conclusion
Anterior 0–2 mm zone densitometry at the third-month post accelerated CCL can be used to detect different staging of keratoconus. Due to the correlation between final aberrometric and peak densitometric values in keratoconic eyes, peak densitometric values can be used as a prognostic factor for the final visual outcomes after accelerated CCL.
Heart Rate related to Accuracy of left ventricular strain parameters derived from the single-shot compressed sensing cine CMR images of patients with cardiovascular disease
Authors: Chen Yang , Xu Panpan , Wang Jun , Qian Wen , Liu Wangyan , Zhu Yinsu , Zhou Xiao , Xu Yi , Zhu Xiaomei 
Published: September 2022

Abstract
Objectives
Left ventricular (LV) global strain values from single-shot compressed sensing (ss-CS) cine imaging of cardiovascular magnetic resonance (CMR) are significantly underestimated compared with those from conventional segmented cine imaging (regarded as gold standard). This study aimed at exploring the patient-related factors of this underestimation and finding a relatively easy way of adjustment in clinical cardiovascular patients.
Methods
Patients with ss-CS cine and standard segmented cine CMR were retrospectively enrolled. Different groups in terms of LV wall thickness (thinned < 6mm, normal 9-12mm and thickened ≥ 15mm) and ejection fraction (EF) were established. Absolute and relative differences of LV global peak strains (GPSs) were calculated. Stepwise multivariable linear regression models were used to find the independent patient-related factors influencing the difference.
Results
Among 62 patients (mean age, 50 ± 16 years; heart rate, 71 ± 13 beats/min), patients with normal, thinned and thickened wall thickness were 19, 22 and 21 respectively and with LV systolic dysfunction (EF < 50%) were 31. LV GPSs by ss-CS cine were significantly underestimated. Absolute underestimations of GPSs were significantly different among different wall thickness groups and EF groups respectively (all P < 0.05), while relative underestimations of GPSs were not related to LV wall thickness or EF. In stepwise multivariable analysis, EF and heart rate were both associated with absolute decline (β values: from 0.244 to 0.485, P < 0.05). However, only heart rate was independently assassinated with relative underestimation in global circumferential and longitudinal strains (circumferential: β value = 0.320, P = 0.011; longitudinal: β value = 0.388, P = 0.002).
Conclusions
Compared to the traditional segment cine, ss-CS cine indeed underestimates LV strain parameters in cardiovascular patients and relative underestimations in GPSs could be adjusted by heart rate. Improving and standardized imaging techniques for high-speed CMR imaging are still needed.
Production Performance, Defensive, Hygienic, Swarming, and Foraging Behavior of Apis mellifera scutellata bee race
Authors: Tarekegn Alayu , Faji Mulisa , Abebe Alemayehu 
Published: September 2022

Abstract
Honey bee colonies exhibit a wide range of behavioral variations depending on genetic origin and environmental factors. Therefore, the performance evaluation of honey bee races is critical to laying a foundation for future selection and improvement in Ethiopia. Thirty colonies of Apis mellifera scutellata (A.m.scutellata) similar in resources contained in the hive were kept in improved box hives and evaluated through reproductive swarming tendency, foraging activity, defensive behavior, hygienic behavior, brood population, honey production, and absconding behavior during the active season and dearth season. In the study area, the A.m.scutellata race has a higher swarming tendency in the active season, with up to 3.24 queen caps per hive prepared per year. Defensive behavior during the active season takes an average of 25.41second after disturbances and follows up to a 212.20-meter distance. But during the dearth season, the colony slightly took a long time to reach aggressiveness after disturbance (31.28 seconds) and followed the observer for a short distance (45.58 meters). The closed brood production is higher (149 units per hive) during the active season and nectar production units per hive are reduced by 50% as compared to the dearth season. The yielding performance of the race per frame ranged from 1.3 kg to 1.5 kg, and an average of 14 kg of honey per harvest. The A.m.scutellata exhibited an absconding tendency of 34.5% if there was any disruption. A.m. scutellata showed good performance in hygienic behaviors (>95%), but undesirable behaviors in defensive behavior and swarming tendency make it difficult to manage honey bees. However, the race has good performance in foraging and hygienic behaviors. Further, studies of the honey bee race through selection and breeding could be conducted to reduce the higher aggressiveness and swarming tendency of A. m. scutellata to improve production performance.
Knee function, quality of life, pain, and living conditions after distal femoral resection knee arthroplasty for non-tumor indications
Authors: Corap Yasemin , Brix Michael , Brandt Julie R. , Emmeluth Claus , Lindberg-Larsen Martin 
Published: September 2022

Abstract
Background: Distal femoral resection knee arthroplasty is a limb salvage procedure. The impact of distal femoral resection arthroplasty on patient function and health status is unknown. The aim of this study was to report knee function, quality of life, knee pain, and living conditions after distal femoral resection knee arthroplasty for non-tumor indications.
Methods: Of 52 patients (52 knees) undergoing distal femoral resection knee arthroplasty in a single institution between 2012 and 2021, 22 were excluded as 3 patients had ≤ 90 days follow-up, 6 had died, and 13 declined or were unable to participate for unrelated reasons. Thus, 30 patients were included and interviewed by telephone in March 2021 (mean follow-up 3.5 years after surgery). Patient completed the Oxford Knee Score (0-48, 48 best), EQ-5D-5L, and the Copenhagen Knee ROM, and information on pain and living conditions was obtained.
Results: The mean age was 67.9 years (SD 13.6), and 21 (70%) were female.
Mean total Oxford Knee Score was 29.9 (SD 10.5), mean Copenhagen Knee ROM flexion was 116° (SD 21.6), and mean extension was –2° (SD10.1). Mobility aids were used by 18 (60%) patients, i.e. a cane (30%), walker (26.7%) or wheelchair (3.3%).
Mean EQ-5Dindex score was 0.70 (SD 0.22) and mean EQ-5D VAS score was 55.4 (SD 23.9). Nine (30%) patients used paracetamol or NSAID and 2 (6.7%) used opioids for knee pain. Mean VAS knee pain score was 1.30 (SD 2.2) at rest and 2.8 (SD 3.1) when walking.
Most (90%) patients lived in their own home, with only 3 patients in nursing homes. Two-thirds (66.7%) required no home care, 5 (16.6%) received home care 1-2 times over 2 weeks, and 5 (16.6%) every day.
Conclusion: Distal femoral resection knee arthroplasty appears to be a viable treatment option for non-tumor indications. Acceptable patient outcomes were achieved in terms of functional status and quality of life, especially considering treatment alternatives such as femoral amputation.
Terpene produced by co-expression of TPS and P450 genes from Lavandula angustifolia protect plant from herbivores attacks during budding stages
Authors: Ling Zhengyi , Li Jingrui , Dong Yanmei , Zhang Wenying , Bai Hongtong , Li Shu , Wang Su , Li Hui , shi lei 
Published: September 2022

Abstract
To defend themselves against herbivore attacks, plants produce a variety of volatiles, especially during the early stages of development. During the budding phases of Lavandula angustifolia , three genes ( La TPS7, La TPS8, and La CYP71D582) were discovered to be highly expressed. The La TPS7 catalyzes total eight different compounds in vitro , including camphene, myrcene, and limonene, among others. The La TPS8 converted ten volatiles using geranyl diphosphate and nerolidyl diphosphate as substrates. The plastid-located La TPS7 gene produced limonene when it was overexpressed in tobacco. The endoplasmic reticulum enzyme La CYP71D582 may further convert limonene to carveol. The La TPS8 present in plastids creates α-pinene and sylvestrene, according to in vitro tests. The limonene and carveol were discovered to repel Myzus persicae while attracting Harmonia axyridis confirmed by standards test. In Arabidopsis thaliana , a GUS staining test was used to evaluate the promoter activity of La TPS7 and La CYP71D582, and it was discovered that wounding may boost La TPS7 expression levels. The volatile compounds generated by La TPS7, La TPS8, and La CYP71D582 were found to be important in plant protection. In practice, biological control can be applied to promote human and environmental health via plant approaches.
Decrease of cancer diagnosis during COVID-19 pandemic: a systematic review and meta-analysis.
Authors: Angelini Marco , Teglia Federica , Astolfi Laura , Casolari Giulia , Boffetta Paolo 
Published: September 2022

Abstract
Background: Many health services, including cancer care, have been affected by the COVID-19 epidemic. This study aimed at providing a systematic review of the impact of the epidemic on cancer diagnostic tests and diagnosis worldwide.
Methods: In our systematic review and meta-analysis, databases such as Pubmed, Proquest and Scopus were searched comprehensively for articles published between January 1st, 2020 and December 12th, 2021. Observational studies and articles that reported data from single clinics and population registries comparing the number of cancer diagnostic tests and/or diagnosis performed before and during the pandemic, were included. Two pairs of independent reviewers extracted data from the selected studies. The weighted average of the percentage variation was calculated and compared between pandemic and pre-pandemic periods. Stratified analysis was performed by geographic area, time interval and study setting. The review was registered on PROSPERO (ID: CRD42022314314).
Findings: The review comprised 61 articles, whose results referred to the period January – October 2020. We found an overall decrease of -37.3% for diagnostic tests and -27.0% for cancer diagnosis during the pandemic. For both outcomes we identified a U-shaped temporal trend, with an almost complete recovery for the number of cancer diagnosis after May 2020. We also analyzed differences by geographic area and screening setting.
Interpretation: We provided a summary estimate of the decrease in cancer diagnosis and diagnostic tests, during the first phase of the COVID-19 pandemic. The delay in cancer diagnosis could lead to an increase in the number of avoidable cancer deaths. Further research is needed to assess the impact of the pandemic measures on cancer treatment and mortality.
Systematic review and meta-analysis of efficacy and safety of continuous positive airways pressure versus high flow oxygen cannula in acute bronchiolitis
Authors: Buendía Jefferson Antonio , Feliciano-Alfonso John Edwin , Laverde Mauricio Fernandez 
Published: September 2022

Abstract
Introduction.
There are a trend towards increasing use of High-Flow Nasal Cannula (HFNC), outside of paediatric intensive care unit . Give this trend is necessary to update the actual evidence and to assess available published literature to determinate the efficacy of HFNC over Continuous Positive Air Pressure (CPAP) as treatment for children with severe bronchiolitis.
Methods
We searched MEDLINE, EMBASE, LILACS, and COCHRANE Central, and gray literature in clinical trials databases (www.clinicaltrials.gov), from inception to June 2022. The inclusion criteria for the literature were randomized clinical trials (RCTs) that included children < 2 years old, with acute moderate or severe bronchiolitis. All study selection and data extractions are performed independently by two reviewers
Results
The initial searches including 106 records.Only five randomized controlled trial that met the inclusion criteria were included in meta-analysis. The risk of invasive mechanical ventilation was not significantly different in CPAP group and HFNC group [OR: 1.18 , 95% CI (0.74, 1.89), I² = 0%] (very low quality). The risk of treatment failure was less significantly in CPAP group than HFNC group [OR: 0.51 , 95% CI (0.36, 0.75), I² = 0%] (very low quality)
Conclusion
We do not found , with low certainty, that CPAP were superior to HFNC in decreasing the risk of mechanical ventilation or mortality. CPAP reduces de risk of therapeutic failure with a highest risk of non severe adverse events. More trials are needed to confirm theses results.
A Survival Analysis of Socio-Demographic and Clinical Predictors Among Hospitalized COVID-19 Patients in Southern Iran
Authors: Esfandiari Atefeh , Kiani Jamileh , Amiri Batool , mahmoodi Marzieh , Abbasi Fatemeh , Javanmardi Erfan , Yazdanpanah Ahmad , Akhlaghi Allahkaram , Salari Hedayat 
Published: September 2022

Abstract
Background: This study aimed to evaluate the socio-demographic, clinical, and laboratory risk factors in hospitalized COVID-19 patients during the first six months of the SARS-CoV-2 epidemic.
Method: This retrospective hospital-based cross-sectional study included all laboratory-confirmed cases of the COVID-19 virus that were admitted to the Shohadaye-Khalije-Fars Hospital in Bushehr, Iran, from February 22, 2020 to September 21, 2020. The patients' records were reviewed during the hospitalization period. The global COVID-19 clinical platform, i.e., the World Health Organization Rapid Case Report Form was used as the data collection tool. We conducted the survival analysis using the Kaplan–Meier and the stepwise Cox regression analyses.
Results: The analysis included 2108 confirmed cases of COVID-19 with a mean age of 47.81 years (SD 17.78); 56.8% men, 43.2% women and 6.3% (n = 133) deaths. After adjustment, it was found that factors associated with an increased risk of death consisted of chronic kidney disease, intensive care unit admission, cancer, and hemoptysis. The 7-day survival rate was 95.8%, which decreased to 95.1%, 94.0%, and 93.8% on days 14, 21, and 28 of hospitalization, respectively.
Discussion and Conclusion: Older COVID-19 patients with manifestation of hemoptysis and a past medical history of chronic kidney disease and cancer, should be closely monitored to prevent disease deterioration and death, and also should be admitted to the intensive care unit.
Dimensional Structure of one-year Post-COVID-19 Neuropsychiatric and Somatic Sequelae and Association with Role Impairment
Authors: Leung Owen N.W. , Chiu Nicholas K.H. , Wong Samuel Y.S. , Cuijpers Pim , Alonso Jordi , Chan Paul K.S. , Lui Grace , Wong Eliza , Bruffaerts Ronny , Yip Benjamin H.K. , Mortier Philippe , Vilagut Gemma , Kwok Dora , Lam Linda C.W. , Kessler Ronald C. , Mak Arthur D.P. 
Published: September 2022

Abstract
This study examined the latent structure of the broad range of complex neuropsychiatric morbidities occurring one year after COVID-19 infection. As part of the CU-COVID19 study, 248 (response rate = 39·3%) of 631 adults hospitalized for COVID-19 infection in Hong Kong completed an online survey between 3-2021 and 1-2022. Disorder prevalence was compared against a random non-infected household sample (n = 1837). 248 surveys were received on average 321 days post-infection (Mean age: 48·9, 54% female, moderate/severe/critical infection: 58·2%). 32·4% were screened to have > = one mental disorder, 78·7% of whom had concurrent fatigue/subjective cognitive impairment (SCI). Only PTSD (19·1%) was significantly more common than control (14%, p = 0·047). Latent profile analysis classified individuals into P1(12·4%)-no current neuropsychiatric morbidities, P2 (23·1%)-SCI/fatigue, P3 (45·2%)-anxiety/PTSD, P4 (19·3%)-depression. SCI and fatigue pervaded in all profiles (P2-4) with neuropsychiatric morbidities one-year post-infection. SHAP: PTSD, anxiety and depressive symptoms were most important in differentiating P2-4. Past mental health and P4 independently predicted functional impairment. Neuropsychiatric morbidity was associated with past mental health, reduced resilience, financial problems, but not COVID-19 severity. Their confluence with depressive and anxiety symptoms predicted impairment and are associated with psychological and environmental factors.
Short- and long-term outcomes of Laparoscopic low anterior resection with “dog ear” invagination anastomosis for mid and distal rectal cancer a propensity score matched analysis
Authors: zhang liang , xie zhi-yuan , Lin H. , Liu R. , Gong L. , lv xiao-peng 
Published: September 2022

Abstract
Background:
The lateral intersecting margin (dog-ear) was a weak spot of the double stapled technique (DST), We designed "dog-ear" invagination anastomosis (DAIA), which could eliminate the "dog-ear" in laparoscopic anterior resection.
Methods:
A total of 202 patients underwent elective curative LLAR + DST (n = 143) or LLAR + DAIA (n = 59) were enrolled in the study. Propensity score matching (PSM) was used to minimize the adverse effects. The clinical data between LLAR + DST and LLAR + DAIA was compared.
Results:
After PSM, 53 pairs of the LLRA + DST and LLRA + DAIA patients were enrolled in the study. The LLRA + DAIA group has a higher level (3.50 ± 1.03 vs. 2.87 ± 1.10, p = 0.01) of the anastomosis than that of the LLRA + DST group. Patients in LLAR + DAIA group have a lower incidence of protecting loop ileostomy compared to LLAR + DST group(20.75% vs. 5.66%, P < 0.05). The LLRA + DAIA patients presented better rates of LARS compare to LLRA + DST patients at 6 months (major LARS 37.74%(n = 20) vs. 67.93% (n = 36); p = 0.007) and 12months (major LARS 13.21% (n = 7) vs. 20.37% (n = 11); p = 0.03) after surgery. The OS and DFS rates were similar (P > 0.05).
Conclusion
Laparoscopic low anterior resection with "dog-ear" invagination anastomosis technique are well-established procedures for patients with low rectal cancer. "Dog-ear" invagination anastomosis technique may reduce the incidence of protecting loop ileostomy and significantly affect LARS score, and demonstrate a positive impact on the quality of life after surgery.
The visual detection of inner abnormal structures and potential geological hazards assessment method for buried rock and soil mass
Authors: Zou Xianjian , Song Huan , Ma Zhimin 
Published: September 2022

Abstract
Aiming at the weak interlayer, potential structural plane or abnormal area that may have some risks in geotechnical engineering, a method of monitoring abnormal structure and evaluating potential geological hazards in geotechnical engineering based on phased array ultrasonic scanning imaging technique was proposed. The real-time ultrasonic video images of the internal structure of rock and soil mass at various positions and different angles in the target area, and the ultrasonic imaging profile of the processed internal abnormal structure can be obtained. The binarization features of abnormal structures in the images were statistically analyzed. The total number of non-zero pixels, non-zero discontinuous light spots and stripe bands is obtained. The ratio of the boundary length of all light spots and stripe bands to the number of pixels occupied by all light spots and stripe bands was obtained. Based on this, the criterion of the degree of potential geological hazards is established, and the visual monitoring of the internal abnormal structure of rock and soil mass and the accurate evaluation of potential geological hazards are realized. Based on the refined diagnosis and analysis of local abnormal areas, this method solves the problems that the existing techniques cannot realize the visual monitoring of the internal fine structure of rock and soil mass and carry out the refined analysis and evaluation of the potential geological hazards. This paper provides a new approach for the stability and safety analysis of geotechnical engineering or slope engineering.