bluuebunny/crossref_metadata_2025_split huggingface dataset:
No substantial excess all-cause mortality among cardiac implantable electronic device patients during the first COVID‑19 lockdown in the Leiden area
Authors: Feijen M. , Egorova A. D. , van der Velde E. T. , Schalij M. J. , Beeres S. L. M. A. 
Published: January 2022

AbstractIn the Netherlands, the coronavirus disease 2019 (COVID‑19) pandemic has resulted in excess mortality nationwide. Chronic heart disease patients are at risk for a complicated COVID‑19 course. The current study investigates all-cause mortality among cardiac implantable electronic device (CIED) patients during the first peak of the pandemic and compares the data to the statistics for the corresponding period in the two previous years. Data of adult CIED patients undergoing follow-up at the Leiden University Medical Centre were analysed. All-cause mortality between 1 March and 31 May 2020 was evaluated and compared to the data for the same period in 2019 and 2018. At the beginning of the first peak of the pandemic, 3,171 CIED patients (median age 70 years; 68% male; 41% ischaemic aetiology) were alive. Baseline characteristics of the 2019 (n = 3,216) and 2018 (n = 3,169) cohorts were comparable. All-cause mortality during the peak of the pandemic was 1.4% compared to 1.6% and 1.4% in the same period in 2019 and 2018, respectively (p = 0.84). During the first peak of the COVID‑19 pandemic, there was no substantial excess mortality among CIED patients in the Leiden area, despite the fact that this is group at high risk for a complicated course of a COVID‑19 infection. Strict adherence to the preventive measures may have prevented substantial excess mortality in these vulnerable patients.
Predictive factors of operability after neoadjuvant chemotherapy in resectable or borderline resectable pancreatic cancer: a single-center retrospective study
Authors: Murakami Masatoshi , Fujimori Nao , Ohno Akihisa , Matsumoto Kazuhide , Teramatsu Katsuhito , Takamatsu Yu , Takeno Ayumu , Oono Takamasa , Abe Toshiya , Ideno Noboru , Ikenaga Naoki , Nakata Kohei , Nakamura Masafumi , Ishigami Kousei , Ogawa Yoshihiro 
Published: January 2022

Abstract
Background/Aims
Recently neoadjuvant chemotherapy (NAC) for pancreatic cancer has been shown to be superior to upfront surgery, but it remains a matter of debate for resectable cases. In clinical practice, some resectable cases may become unresectable after NAC. This study aimed to reveal the outcomes after NAC and to clarify the characteristics of unresected cases.

Methods
The medical records of 142 patients who underwent NAC between 2016 and 2020 were retrospectively reviewed. Patient characteristics, effectiveness of NAC, and outcomes were compared between the surgical group and non-surgical group (NSG). Furthermore, the risk of recurrence limited to in the patients who received NAC with gemcitabine plus nab-paclitaxel, which were mostly administered in this cohort, following R0/R1 resection was assessed.

Results
The overall and R0 resection rates after NAC were 89.1% and 79.7%, respectively. The neutrophil to lymphocyte ratio (NLR) > 2.78 (p = 0.0120) and anatomical borderline resectable pancreatic cancer (p = 0.0044) revealed a statistically significantly correlation with the NSG. On the other hand, NAC week < 8 (p = 0.0285), radiological response, stable disease or progression disease (p = 0.0212), and pathological stage > IIA (P = 0.0003) were significantly associated with recurrence. The tumor response rate was approximately 26.1%, and three patients with ≥ 30% reduction of primary tumor lost excision opportunities because of metastasis, interstitial pneumonia, and vascular invasion.

Conclusions
This study shows incomplete tumor shrinkage benefits, but pre-NAC NLR is a predictive factor for predicting operability after NAC. The NLR can be easily calculated by normal blood test, and can be considered as a suitable marker of operability.
Overrepresentation of Indigenous students in school suspension, exclusion, and enrolment cancellation in Queensland: is there a case for systemic inclusive school reform?
Authors: Graham Linda J. , Killingly Callula , Laurens Kristin R. , Sweller Naomi 
Published: January 2022

AbstractWell-established evidence of the ill-effects of exclusionary school discipline, its disproportionate use on students of colour, and association with the “school-to-prison pipeline” has, in the last decade, led to systemic reforms in the United States, which are successfully reducing exclusion and improving outcomes. Few studies, however, have similarly investigated overrepresentation in Australia, with little attention to systemic reform as a result. In this study, we analysed suspension, exclusion, and enrolment cancellation rates in Queensland (QLD) government schools between 2013 and 2019 and found Indigenous students were consistently overrepresented. Suspension incidents proportionate to enrolments increased for all students, but this increase was faster for Indigenous than non-Indigenous students and driven primarily by steep rises in short suspensions during primary school (Preparatory-6). Exclusions increased—again disproportionately—for Indigenous students, chiefly in secondary school (7–12). During 2019, Physical Misconduct had the highest incident rate for both groups; however, Indigenous students were most overrepresented in suspensions for Disruptive/Disengaged behaviours. Further, while Indigenous students were overrepresented in all QLD regions, one region’s Indigenous suspension rate was higher than all others despite no difference in the distribution of Indigenous/non-Indigenous enrolments across regions. The scale and nature of Indigenous overrepresentation in exclusionary discipline incidents in QLD indicate clear need for further research to secure political commitment to systemic inclusive school reform, as well as to produce high-quality evidence capable of guiding that reform.
Integration of Energy Oriented Manufacturing Simulation into the Life Cycle Evaluation of Lightweight Body Parts
Authors: Dér Antal , Kaluza Alexander , Reimer Lars , Herrmann Christoph , Thiede Sebastian 
Published: January 2022

AbstractRecent years introduced process and material innovations in the design and manufacturing of lightweight body parts for larger scale manufacturing. However, lightweight materials and new manufacturing technologies often carry a higher environmental burden in earlier life cycle stages. The prospective life cycle evaluation of lightweight body parts remains to this day a challenging task. Yet, a functioning evaluation approach in early design stages is the prerequisite for integrating assessment results in engineering processes and thus allowing for a life cycle oriented decision making. The current paper aims to contribute to the goal of a prospective life cycle evaluation of fiber-reinforced lightweight body parts by improving models that enable to predict energy and material flows in the manufacturing stage. To this end, a modeling and simulation approach has been developed that integrates bottom-up process models into a process chain model. The approach is exemplarily applied on a case study of a door concept. In particular, the energy intensity of compression molding of glass fiber and carbon fiber sheet molding compounds has been analyzed and compared over the life cycle with a steel reference part.
A posteriori verification of the positivity of solutions to elliptic boundary value problems
Authors: Tanaka Kazuaki , Asai Taisei 
Published: January 2022

AbstractThe purpose of this paper is to develop a unified a posteriori method for verifying the positivity of solutions of elliptic boundary value problems by assuming neither $$H^2$$

H
2

-regularity nor $$ L^{\infty } $$

L
∞

-error estimation, but only $$ H^1_0 $$

H
0
1

-error estimation. In (J Comput Appl Math 370:112647, 2020), we proposed two approaches to verify the positivity of solutions of several semilinear elliptic boundary value problems. However, some cases require $$ L^{\infty } $$

L
∞

-error estimation and, therefore, narrow applicability. In this paper, we extend one of the approaches and combine it with a priori error bounds for Laplacian eigenvalues to obtain a unified method that has wide application. We describe how to evaluate some constants required to verify the positivity of desired solutions. We apply our method to several problems, including those to which the previous method is not applicable.
Assessment of Challenges and Opportunities and Identification of Approaches and Innovations in COVID-19 Pandemic Management by Different States in India: A Qualitative Approach
Authors: Kundapur Rashmi , Rashmi Anusha , Velamala Sunhitha , Aggarwal Sumit , Shringarpure Kalpita , Gaitonde Rakhal , Modi Bhavesh ,   COVID-19 Trailblazer Probe Team
Published: January 2022

Abstract
Objective
The primary objective of the study was to compare the challenges in implementing various COVID-19-related public health strategies and activities between the selected high health index and low health index states. The secondary objective was to identify the differently managed mechanisms adopted by the health-care delivery system across the states to maintain their functioning during the COVID-19 pandemic.

Setting
Eight states were divided into two groups; based on their health index and vulnerability index ranking—Kerala, Maharashtra, Gujarat, and Karnataka in top four (Group 1) and Delhi, Tripura, Rajasthan, and Orissa in bottom four states (Group 2).

Results
There was lack of private sector involvement in both the groups of the states, more so in Group 2. Although transport-related issues were similar in both groups, lack of provision of vehicles for transport for carrying out various COVID and non-COVID activities seemed to be more prominent in Group 2. More obstacles related to infrastructure were observed in Group 1 states. In terms of innovations, commonalities lay in convergence of multiple departments for monitoring, contact tracing, essential supplies, and transportation. Both groups managed routine health services and fund allocation with nearly equal vigour. Major challenges faced were related to human resource, policy management, transportation, routine health services, data management, and infrastructure. HR-related challenges in top four states included confusion due to frequent change in guidelines, unclear micro-containment, and testing guidelines. Discharge guidelines and SOPs related to home isolation of slum dwellers, inter-departmental cooperation and coordination issues faced in greater proportion in top four states; issues with fund allocation for local needs were faced by the Group 2 states. Innovations implemented to meet hurdles faced during the pandemic could be categorized under heads of ‘human resource’, ‘community actions’, ‘policy management’, ‘inter-departmental coordination’, ‘use of technology and media’, and ‘fund allocations’. There was private–public partnership; use of other human resource for health-care delivery; use of technology for health-care delivery was seen in all states but more so in Group 1 states.

Conclusion
States with higher health index and lower vulnerability index, i.e., Group 1 states faced fewer challenges than those in Group 2. Innovative measures taken at local level to tackle problems posed by the pandemic were unique to the situations presented to them and helped control the disease as effectively as they could.
The Impact of Risk Factor Control on Health-Related Quality of Life in Individuals with High Cardiovascular Disease Risk: A Cross-sectional Study Based on EQ-5D Utility Scores in Inner Mongolia, China
Authors: Cao Ning , Hao Zhihui , Niu Liwei , Zhang Nan , Zhu Hao , Bao Han , Yan Tao , Fang Xin , Xu Xiaoqian , Li Lehui , Liu Yan , Xia Yuan , Su Xiong , Zhang Xingguang 
Published: January 2022

Abstract
Objectives
To assess the impact of cardiovascular disease (CVD) risk factor control on health-related quality of life (HRQoL), as well as the other influencing factors of HRQoL among high CVD risk individuals.

Methods
From 2015 to 2017, residents of six villages or communities in Inner Mongolia, selected using a multi-stage stratified cluster random sampling method, were invited to complete a questionnaire and undergo physical examination and laboratory testing. We selected participants whose predicted 10-year risk for CVD exceeded 10% as those with high CVD risk. HRQoL in individuals with high CVD risk was investigated based on the EuroQol-5 Dimension (EQ-5D) scale. The Chinese utility value integral system was used to calculate EQ-5D utility scores, and the Tobit regression model was used to analyze the influencing factors of HRQoL among individuals with high CVD risk.

Results
Of 13,359 participants with high CVD risk, 65.63% reported no problems in any of the five dimensions; the most frequently reported difficulty was pain/discomfort. The median utility score was 1.000 (0.869, 1.000). Participants with hypertension, and uncontrolled glycemic and blood lipids had lower HRQoL. In addition, sex, age, living environment, education level, household income, and medical insurance were influencing factors of HRQoL.

Conclusion
Sex, age, living environment, education level, household income, medical insurance, hypertension, and whether glycemic and blood lipids control or not are related to HRQoL of high CVD risk individuals.
Measures of Extropy for Concomitants of Generalized Order Statistics in Morgenstern Family
Authors: Almaspoor Zahra , Jafari Ali Akbar , Tahmasebi Saeid 
Published: January 2022

AbstractIn this paper, a measure of extropy is obtained for concomitants of m-generalized order statistics in the Morgenstern family. The cumulative residual extropy (CREX) and negative cumulative extropy (NCEX) are presented for therth concomitant of m-generalized order statistics. In addition, the problem of estimating the CREX and NCEX is studied utilizing the empirical method in concomitants of m-generalized order statistics. Some applications of these results are given for the concomitants of order statistics and record values.
How does business power operate? A framework for its working mechanisms
Authors: Babic Milan , Huijzer Jouke , Garcia-Bernardo Javier , Valeeva Diliara 
Published: January 2022

AbstractThe global financial crisis of 2008, its following bank bailouts, and associated corporate impunity sparked a renewed interest in the concept of the structural power of business and the question of “who rules?” in capitalist societies. This new wave of scholarship mitigated some of the problems of the original, theory-driven discussions from the 1970s and 1980s. But despite significant advancements in the empirical identification of business power, we lack a unified framework for studying its working mechanisms. So-called hybrid approaches, drawing on instrumental and structural power for their analyses, display high potential for such a unified and easily applicable framework. We build on this hybrid tradition and propose a novel model that integrates instrumental and structural power analysis into a basic framework. With this, we recalibrate the often rigid division between instrumental and structural power forms and emphasize the role of perceptions as key for understanding the dynamics of business power over time. We illustrate this parsimonious framework by an analysis of the plans of the Dutch government to abolish a dividend tax in 2018 that would have benefited a number of large multinationals but collapsed before implementation.
Acute Traumatic Subdural Hematoma and Anticoagulation Risk
Authors: Kia Maryam , Saluja Rajeet Singh , Marcoux Judith 
Published: January 2022

ABSTRACT:Background:Anticoagulation is used to prevent thromboembolic events. It is a common practice to hold anticoagulation in the first few days following a traumatic brain injury (TBI) with intracranial hemorrhage. However, traumatic subdural hematomas (SDH) are prone to re-hemorrhage long after the trauma. Data are scarce in the literature on the best timing to resume anticoagulation following a TBI.Methods:Review of 95 consecutive patients admitted to a level 1 trauma center with a diagnosis of traumatic SDH and requiring anticoagulation. The reasons for anticoagulation, the amount of time without anticoagulation, CT characteristics, and the incidence of thromboembolic events or SDH re-hemorrhage were collected.Results:41.3% used anticoagulation for coronary artery disease and peripheral vascular disease, 24% for atrial fibrillation, 12% for cardiac valve replacement, and 12% for venous thromboembolic events. Anticoagulation was held a median of 67 days. For most patients (82.1%), anticoagulation was re-introduced once the SDH had completely resolved. For 17.9%, anticoagulation was restarted while the SDH had not completely resolved. One (1.1%) patient suffered from an atrial clot while anticoagulation was held. For those with residual SDH, 41.2% suffered from a SDH re-hemorrhage and 17.6% required surgery. The risk of re-hemorrhage climbed to 62.5% if the SDH remnant was large.Conclusion:Anticoagulation while there is a residual SDH was associated with a significant risk of re-hemorrhage. This risk should be weighed against the risk of holding anticoagulation.
Fast nanopore sequencing data analysis with SLOW5
Authors: Gamaarachchi Hasindu , Samarakoon Hiruna , Jenner Sasha P. , Ferguson James M. , Amos Timothy G. , Hammond Jillian M. , Saadat Hassaan , Smith Martin A. , Parameswaran Sri , Deveson Ira W. 
Published: January 2022

AbstractNanopore sequencing depends on the FAST5 file format, which does not allow efficient parallel analysis. Here we introduce SLOW5, an alternative format engineered for efficient parallelization and acceleration of nanopore data analysis. Using the example of DNA methylation profiling of a human genome, analysis runtime is reduced from more than two weeks to approximately 10.5 h on a typical high-performance computer. SLOW5 is approximately 25% smaller than FAST5 and delivers consistent improvements on different computer architectures.
Two divergent haplotypes from a highly heterozygous lychee genome suggest independent domestication events for early and late-maturing cultivars
Authors: Hu Guibing , Feng Junting , Xiang Xu , Wang Jiabao , Salojärvi Jarkko , Liu Chengming , Wu Zhenxian , Zhang Jisen , Liang Xinming , Jiang Zide , Liu Wei , Ou Liangxi , Li Jiawei , Fan Guangyi , Mai Yingxiao , Chen Chengjie , Zhang Xingtan , Zheng Jiakun , Zhang Yanqing , Peng Hongxiang , Yao Lixian , Wai Ching Man , Luo Xinping , Fu Jiaxin , Tang Haibao , Lan Tianying , Lai Biao , Sun Jinhua , Wei Yongzan , Li Huanling , Chen Jiezhen , Huang Xuming , Yan Qian , Liu Xin , McHale Leah K. , Rolling William , Guyot Romain , Sankoff David , Zheng Chunfang , Albert Victor A. , Ming Ray , Chen Houbin , Xia Rui , Li Jianguo 
Published: January 2022

AbstractLychee is an exotic tropical fruit with a distinct flavor. The genome of cultivar ‘Feizixiao’ was assembled into 15 pseudochromosomes, totaling ~470 Mb. High heterozygosity (2.27%) resulted in two complete haplotypic assemblies. A total of 13,517 allelic genes (42.4%) were differentially expressed in diverse tissues. Analyses of 72 resequenced lychee accessions revealed two independent domestication events. The extremely early maturing cultivars preferentially aligned to one haplotype were domesticated from a wild population in Yunnan, whereas the late-maturing cultivars that mapped mostly to the second haplotype were domesticated independently from a wild population in Hainan. Early maturing cultivars were probably developed in Guangdong via hybridization between extremely early maturing cultivar and late-maturing cultivar individuals. Variable deletions of a 3.7 kb region encompassed by a pair of CONSTANS-like genes probably regulate fruit maturation differences among lychee cultivars. These genomic resources provide insights into the natural history of lychee domestication and will accelerate the improvement of lychee and related crops.
An ultrafast piezoelectric Z-scanner with a resonance frequency above 1.1 MHz for high-speed atomic force microscopy
Authors: Shimizu Masahiro , Okamoto Chihiro , Umeda Kenichi , Watanabe Shinji , Ando Toshio , Kodera Noriyuki 
Published: January 2022

The Z-scanner is the major component limiting the speed performance of all current high-speed atomic force microscopy systems. Here, we present an ultrafast piezoelectric Z-scanner with a resonance frequency above 1.1 MHz, achieving a record response time of ∼0.14 µs, approximately twice as fast as conventional piezoelectric-based Z-scanners. In the mechanical design, a small piezo-stack is supported at its bottom four vertices on a cone-like hollow, allowing the resonance frequency of the Z-scanner to remain as high as that of the piezo in free vibration. Its maximum displacement, ∼190 nm at 50 V, is large enough for imaging bio-molecules. For imaging bio-molecules in a buffer solution, the upper half of the Z-scanner is wrapped in a thin film resistant to water and chemicals, providing an excellent waterproof and mechanical durability without lowering the resonance frequency. We demonstrate that this Z-scanner can observe actin filaments, fragile biological polymers, for more than five times longer than the conventional Z-scanner at a tip velocity of 800 µm/s.
Design and development of water-immersible two-channel high-voltage spike pulser for under-water inspection and gauging of pipes
Authors: Kumar N. Pavan , Patankar V. H. 
Published: January 2022

A water-immersible two-channel high-voltage (HV) spike pulser has been designed, developed, and mounted inside the IP 67 (Ingress Protection 67) grade enclosure, and it is suitable for the ultrasonic Pipe Inspection and Gauging (PIG) system utilized in the petrochemical industry. Such a critical and strategic application requires a portable, miniaturized, and water-immersible water-tight pulser module, which resides inside the pipe carrying water or liquid petrochemicals. The developed spike pulser printed circuit board (PCB) generates a HV negative spike pulse up to −300 V and 100 ns half-amplitude pulse width, required for the energization of ultrasonic immersion transducers of 5–10 MHz frequency. The water-immersible pulser is mounted inside the water-tight IP 67 grade enclosure, and it is operated through an external DC power supply/lithium batteries. The evaluation of the module was carried out using a two-channel water-immersible HV spike pulser, in-house developed preamplifier, and inspection head supported by four sets of spring-loaded Teflon balls for centering, and the inspection head carries two ultrasonic immersion transducers placed 180° apart and a sample SS pipe with a length of 400 mm, Inner Diameter of 200 mm, and Wall Thickness of 9 mm. The two-channel pulser module was evaluated in water to measure the dimensions of the sample SS pipe. This two-channel water-immersible novel spike pulser has dedicated circuitry, and each channel is a standalone PCB and it operates through external LV and HV DC supplies. The module can be scaled up to 256 channels for dimension measurement and flaw detection of long length pipes. In the absence of any literature available on the water-immersible pulser for PIG systems, the present two-channel pulser module has been designed and developed, and the module was evaluated by gauging of the SS pipe from inside. This paper provides the details of the water-immersible HV spike pulser module suitable for the gauging of metallic pipes.