bluuebunny/crossref_metadata_2025_split huggingface dataset:
One‐pot Synthesis of Phosphorus‐modified ZSM‐5 Zeolite by Solid‐state Method and its MTO Catalytic Performance
Authors: Zhou Zihan , Wang Xingwen , Li Junjie , Gao Yu , Yu Rui , Jiang Rongli 
Published: December 2022

AbstractThe traditional hydrothermal synthesis strategy of ZSM‐5 zeolite is energy‐consumption accompanying by pollution issues. Herein, phosphorus‐modified layered ZSM‐5 zeolites (PZ) were obtained by one‐pot synthesis under solvent‐free conditions. The synthesized samples were fully characterized by XRD, SEM, BET, NH3‐TPD and FTIR. The effect of phosphorus addition on the morphology and catalytic activity of ZSM‐5 was investigated. The results showed that phosphorus‐modified ZSM‐5 zeolites exhibited higher light olefin (ethylene and propylene) selectivity (above 50 %) and longer catalytic lifetime (33 h) in methanol to olefin (MTO) reaction when the weight hourly space velocity was 4 h−1. Phosphorus‐modified ZSM‐5 zeolite synthesized by in situ solvent‐free method, which not only reduced the discharge of sewage but also showed a simple method to realize the introduction of phosphorous species, which provided a new idea for phosphorus modification of ZSM‐5 zeolite.
Readily Accessible Strained Difunctionalized trans‐Cyclooctenes with Fast Click and Release Capabilities**
Authors: Sondag Daan , Maartense Luuk , de Jong Heleen , de Kleijne Frank F. J. , Bonger Kimberly M. , Löwik Dennis W. P. M. , Boltje Thomas J. , Dommerholt Jan , White Paul B. , Blanco‐Ania Daniel , Rutjes Floris P. J. T. 
Published: December 2022

AbstractThe click reaction between a functionalized trans‐cyclooctene (TCO) and a tetrazine (Tz) is a compelling method for bioorthogonal conjugation in combination with payload releasing capabilities. However, the synthesis of difunctionalized TCOs remains challenging. As a result, these compounds are poorly accessible, which impedes the development of novel applications. In this work, the scalable and accessible synthesis of a new bioorthogonal difunctionalized TCO is reported in only four single selective high yielding steps starting from commercially available compounds. The TCO‐Tz click reaction was assessed and revealed excellent kinetic rates and subsequently payload release was shown with various functionalized derivatives. Tetrazine triggered release of carbonate and carbamate payloads was demonstrated up to 100 % release efficiency and local drug release was shown in a cellular toxicity study which revealed a >20‐fold increase in cytotoxicity.
Regioregular Non‐Fused Polymerized Small Molecular Acceptors Enabling Efficient All‐Polymer Solar Cells†
Authors: Wu Baoqi , Li Youle , Tian Shizeng , Zhang Yue , Pan Langheng , Liu Kangzhe , Yang Mingqun , Huang Fei , Cao Yong , Duan Chunhui 
Published: December 2022

Comprehensive SummaryThe regioregularity induced by the isomers of the end‐groups has been widely recognized as a key factor that determines the photovoltaic properties of polymerized small molecular acceptors (PSMAs) in all‐polymer solar cells (all‐PSCs). However, the influence of regioregularity on the photovoltaic properties of non‐fused PSMAs has not been explored yet. In this contribution, two regioregular non‐fused PSMAs, PFBTz‐T‐γ and PFBTz‐T‐δ, were synthesized for the first time by using the monomers with isomeric pure end‐groups. Compared with PFBTz‐T‐δ, PFBTz‐T‐γ has more compact and more ordered packing in solid state, which results in a more red‐shifted optical absorption and a higher electron mobility. More remarkably, PFBTz‐T‐γ and PFBTz‐T‐δ exhibited huge difference in photovoltaic performance in all‐PSCs, which offered the power conversion efficiencies (PCEs) of 9.72% and 0.52%, respectively. Further studies have unveiled that the higher PCE of PFBTz‐T‐γ is due to more efficient exciton dissociation, higher and more balanced electron/hole mobility, and less charge recombination as a result of favorable morphology of the blend film. This work demonstrates that the development of regioregular non‐fused PSMAs by tuning the polymerization sites is an effective strategy for obtaining high‐efficiency all‐PSCs.
Endoscopic balloon cryoablation plus transurethral resection for bladder cancer: A phase 2, multicenter, randomized, controlled trial
Authors: Xu Chenyang , Jiang Shuai , Zou Lujia , Sheng Lu , Shi Guowei , Xu Bin , Wang Zhong , Xu Danfeng , Xie Xin , Luo Jianfeng , Guo Jianming , Jiang Haowen 
Published: December 2022

AbstractBackgroundCryotherapy is a prevalent percutaneous ablative therapy for solid tumors. Here, we report a novel device using liquid nitrogen for endoscopic cryotherapy of bladder cancer.MethodsIn this multicenter, randomized, parallel controlled, Phase 2 trial, we compared endoscopic balloon cryoablation (EBCA) with a single instillation (SI) of pirarubicin after transurethral resection (TUR). Eligible participants were randomly assigned (1:1) to the TUR‐EBCA or TUR‐SI group. Repeat TUR or tissue biopsies were performed to evaluate residual tumor at 4 to 6 weeks after primary treatment. The primary end point was the local control rate. The secondary end points included the tumor upgrading/upstaging, catheter indwelling duration, and adverse events.ResultsIn total, 205 patients received EBCA or SI after TUR between November 2017 and September 2020, of whom 163 completed all the required interventions. In the per‐protocol set, the local control rate was 91.5% (75/82) in TUR‐EBCA group compared with 76.5% (61/81) in TUR‐SI group (risk difference, 15%; 95% CI, 0.03–0.27, p < .001), meeting the criteria for noninferiority. Similar results were found in the modified intention‐to‐treat analysis. Tumor upgrading/upstaging was found in five patients from the TUR‐SI group. There was no significant difference in the catheter indwelling duration (5.1 vs. 5.2 days, p = .76) or serious adverse event rate (3.0% vs. 3.9%, p = .52). The median follow‐up time of post hoc analysis was 31 (range, 15–50) months. Patients in the TUR‐EBCA group had a better recurrence‐free survival and progression‐free survival.ConclusionEBCA is a safe and effective adjuvant therapy with TUR for non–muscle‐invasive bladder cancer.Plain language summary

This is the first randomized trial that evaluated endoscopic cryotherapy after transurethral resection (TUR) of bladder tumors. The efficacy and safety analysis shows endoscopic balloon cryoablation (EBCA) is a promising alternative.

Results report that EBCA is not inferior to a single instillation of intravesical chemotherapy in eliminating residual bladder tumor. Further analysis with ∼3 years’ median follow‐up suggested a better prognosis in patients who received EBCA after TUR.
Short‐term load forecasting of multi‐scale recurrent neural networks based on residual structure
Authors: Zhao Jia , Cheng Pengyu , Hou Jiazhen , Fan Tanghuai , Han Longzhe 
Published: December 2022

SummaryAccurate short‐term load forecasting plays an important role in reducing power generation costs, maintaining supply and demand balance, and stabling the power grids operation. In recent years, deep learning models based on recurrent neural networks (RNN) have been widely used in short‐term load forecasting. Nevertheless, RNN cannot extract multi‐scale features of load data, resulting in low forecasting accuracy. A model for short‐term power load forecasting of residual multiscale‐RNN (RM‐RNN) was proposed in this study. RM‐RNN uses the multilayer RNN network structure. Specifically, each layer sets the dilated convolution with different dilated coefficients to extract the multi‐scale features of the load data. Adjacent networks transfer feature information for feature fusion through the residual structures. The experiment used random sampling data training model, and compared RM‐RNN with multiple deep learning models. The experimental results demonstrated that the mean error of RM‐RNN prediction is the lowest, indicating that dilated convolution can effectively extract multi‐scale features of load data. This result verified the effectiveness of residual structure fusion features, and improved the accuracy of short‐term load forecasting.
The Effect of Terminal Bromoalkoxy Substituents on the Photochromism of Functionalized 2H‐Chromenes
Authors: Chernikova Ekaterina Y. , Perevozchikova Polina S. , Shepel Nikolai E. , Fedorova Olga A. , Fedorov Yuri V. 
Published: December 2022

AbstractA series of 2,2‐diphenyl‐2H‐chromene derivatives bearing electron‐donating groups at the benzopyran ring have been synthesized. A significant effect of the bromoalkoxy chain length and the concentration of chromenes on the conversion of closed (CF) into open forms under UV irradiation and the equilibrium between TC (transoid‐cis) and TT (transoid‐trans) isomers in the photostationary state was found. For chromene derivatives, a sequential (CF→TC→TT) or parallel (CF→TC; CF→TT) mechanism of transformation of the closed form into an open one is possible. A high solution concentration contributes to a significant shift of the photochromic equilibrium towards the TT isomer. The proposed scheme of the ring‐opening reaction was confirmed by the analysis of the NMR spectra of acetonitrile solutions of chromene derivatives obtained by gradual irradiation. The results obtained are important for a deeper understanding of the nature of photochromic reactions.
AD‐associated CSF biomolecular changes are attenuated in KL‐VS heterozygotes
Authors: Driscoll Ira , Ma Yue , Lose Sarah R. , Gallagher Catherine L. , Johnson Sterling C. , Asthana Sanjay , Hermann Bruce P. , Sager Mark A. , Blennow Kaj , Zetterberg Henrik , Carlsson Cynthia M. , Engelman Corinne D. , Dubal Dena B. , Okonkwo Ozioma C. 
Published: December 2022

AbstractIntroductionDementia as an inevitable aging consequence has been challenged and underscores the need for investigations of the factors that confer resilience. We examine whether the functionally advantageous KL‐VS variant of the putative aging suppressor KLOTHO gene attenuates age‐related cognitive decline and deleterious biomolecular changes.MethodsTrajectories of change in memory and executive function (N = 360; 2–12 visits) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers—amyloid beta (Aβ)42, total tau (t‐tau), phosphorylated tau (p‐tau) (N = 112; 2–4 samplings)—were compared between KL‐VS non‐carriers and heterozygotes in middle‐aged and older adults from the Wisconsin Registry for Alzheimer's Prevention and the Wisconsin Alzheimer's Disease Research Center studies.ResultsMemory and executive function declined (p’s 0.001) and CSF t‐tau, p‐tau, t‐tau/Aβ42, and p‐tau/Aβ42 levels increased (all p’s 0.004) with age. The rate of p‐tau accumulation was attenuated for KL‐VS heterozygotes (p = 0.03).DiscussionKL‐VS heterozygosity may confer resilience to AD‐associated biomolecular changes.
Applying stochastic and Bayesian integral projection modeling to amphibian population viability analysis
Authors: Messerman Arianne F. , Clause Adam G. , Gray Levi N. , Krkošek Martin , Rollins Hilary B. , Trenham Peter C. , Shaffer H. Bradley , Searcy Christopher A. 
Published: December 2022

AbstractIntegral projection models (IPMs) can estimate the population dynamics of species for which both discrete life stages and continuous variables influence demographic rates. Stochastic IPMs for imperiled species, in turn, can facilitate population viability analyses (PVAs) to guide conservation decision‐making. Biphasic amphibians are globally distributed, often highly imperiled, and ecologically well suited to the IPM approach. Herein, we present a stochastic size‐ and stage‐structured IPM for a biphasic amphibian, the U.S. federally threatened California tiger salamander (CTS) (Ambystoma californiense). This Bayesian model reveals that CTS population dynamics show greatest elasticity to changes in juvenile and metamorph growth and that populations are likely to experience rapid growth at low density. We integrated this IPM with climatic drivers of CTS demography to develop a PVA and examined CTS extinction risk under the primary threats of habitat loss and climate change. The PVA indicated that long‐term viability is possible with surprisingly high (20%–50%) terrestrial mortality but simultaneously identified likely minimum terrestrial buffer requirements of 600–1000 m while accounting for numerous parameter uncertainties through the Bayesian framework. These analyses underscore the value of stochastic and Bayesian IPMs for understanding both climate‐dependent taxa and those with cryptic life histories (e.g., biphasic amphibians) in service of ecological discovery and biodiversity conservation. In addition to providing guidance for CTS recovery, the contributed IPM and PVA supply a framework for applying these tools to investigations of ecologically similar species.
Recent developments and future perspectives on energy storage and conversion applications of nickel molybdates
Authors: Sanyal Gopal , Mondal Brinti , Rout Chandra Sekhar , Chakraborty Brahmananda 
Published: December 2022

AbstractTransition metal oxides with two different cations in the same crystal structure are considered to perform better as catalysts due to the synergistic effects causing better charge transfer and the availability of more active sites. Chemicals with molybdate anion (MoO4−) have been proven to have vast industrial importance in arenas like catalysis, supercapacitance, nuclear medicine, calorimetry, etc. In particular, nanostructured nickel molybdate (NiMoO4) is a promising entrant as an electrode substance for sophisticated power bank applications, apart from being a catalyst for chemical reactions involving energy conversion. Engineering of NiMoO4 at different scopes has been proven to cause a vast enhancement in the catalytic performance of nanometric NiMoO4 through improvement in redox reaction kinetics during the last couple of decades. This review imparts a precise thought about NiMoO4 considering all its developments in the unearthing of properties, synthesis routes, and analyzing tunability for improvement in attributes towards focused applications.
Double‐RSOA colorless WDM‐PON for 5G fronthaul applications
Authors: de Souza Adelcio M. , Plazas Caio L. M. P. , Celino Daniel R. , Romero Murilo A. 
Published: December 2022

AbstractThe introduction of 5G mobile systems poses significant challenges to the design of the fronthaul structure. The dense coverage, comprising several small cells operating in the millimeter‐wave range, with an enormous number of antennas, makes conventional digital‐radio‐over‐fiber unfeasible. On the other hand, the centralized architecture of the optical fronthaul is well‐suited for the passive optical network (PON) topology, with WDM‐PON as a strong contender due to its capability to establish logical point‐to‐point optical links to each cell site. However, the large‐scale deployment of WDM‐PON requires the availability of colorless transmitters, where the same hardware is able to generate any wavelength needed by the network. In this context, this paper investigates an analog fronthaul configuration over a colorless WDM‐PON for 5G and beyond, employing the techniques of self‐seeding in the downlink and carrier reuse in the uplink. We numerically evaluated the EVM when transmitting 1.25 Gbps at 3.5 GHz and 10 Gbps at 26 GHz in a 20 km optical link. The results are within the 3GPP requirements, demonstrating the feasibility of the proposed fronthaul.
Does green vertical farming offer a sustainable alternative to conventional methods of production?: A case study from Scotland
Authors: Sandison Frances , Yeluripati Jagadeesh , Stewart Derek 
Published: December 2022

AbstractClimate change is an existential global reality that is placing considerable stress on agriculture sectors. With the recognition of the impacts of climate change on food security, there has been a greater uptake of controlled environment agriculture (CEA) to provide climate‐resilient and high‐quality production. Vertical farming (VF) can allow primary production in urban locations as well as reducing seasonality and variability in produce. It is emerging as an alternative to traditional farming methods. This research aimed to explore the major environmental impacts of VF produce in comparison with conventional farming methods, using lettuce as an example crop. Life cycle analysis indicate that electricity consumption by VF account for 91% of the carbon footprint. Under the 2019 Scottish electricity mix, VF did not offer a viable competitor for UK open‐farmed lettuce or Spanish imports in terms of low greenhouse gas emissions (at approximately 1.49 kgCO2 eq. kg−1). However, with increasing use of renewable electricity in the national mix, by 2020, this had dropped to 0.42 kgCO2 eq. kg−1 making it comparable with UK open‐field agriculture (at approximately 0.46 kgCO2 eq. kg−1). Under a 100% renewable electricity generation scenario, VF‐related emissions drop further (to 0.33 kgCO2 eq. kg−1). This would potentially offer a low‐carbon production method not subject to seasonality which is better than that reported by most other production methods and offers higher water and nutrient efficiency. This research highlights green VF as potential alternative for sustainable future produce especially under changing climate scenarios.
Miao sour soup influences serum lipid via regulation of high‐fat diet‐induced intestinal flora in obese rats
Authors: Zhou Qianqian , Qu Zihan , Wang Nanlan , Liu Huijuan , Yang Hongmei , Wang Huiqun 
Published: December 2022

AbstractObesity is associated with the gut microbiota and has been shown to cause gut microbiota disturbances. Our previous studies have demonstrated that Miao sour soup (SS) contains abundant short‐chain fatty acids (SCFAs) which can be used as energy substrates of intestinal flora to selectively stimulate their growth and reproduction. Therefore, we explored whether the intestinal microbiota of rats with high‐fat diet‐induced obesity could be restored to normal by SS intervention. Male obese rats were divided into five groups randomly after successful modeling of obese rats: normal diet, high‐fat diet (HDF), HFD + SS, HFD with antibiotic, and HFD with antibiotic + SS. After 12 weeks of intervention, the weight and serum lipid of obese rats decreased. Furthermore, 16S rRNA analysis showed an imbalance and a decrease in the abundance and diversity of intestinal flora in obese rats, which improved after SS intervention. At the phylum level, Firmicutes increased while Proteobacteria decreased. The composition of the intestinal flora recovered at the genus level, inhibiting the reproduction of pathogenic bacteria, while the levels of SCFA‐producing bacteria such as Blautia and Lactococcus and the levels of SCFAs in cecal contents increased. In addition, SS reduced the levels of TNF‐α and IL‐6 in the intestinal mucosa of obese rats, increased the contents of PYY and GLP‐1 in colon tissue, and increased the expression of tight junction protein Occludin and ZO‐1 in the intestinal epithelium. Taken together, SS can regulate the intestinal flora of obese rats and improve the intestinal flora to facilitate weight loss and lipid reduction.
Physicochemical, microbial, and functional attributes of processed Cheddar cheese fortified with olive oil–whey protein isolate emulsion
Authors: Irfan Shafeeqa , Murtaza Mian Anjum , Mueen ud Din Ghulam , Hafiz Iram , Murtaza Mian Shamas , Rafique Sobia , Ameer Kashif , Abrar Muhammad , Mohamed Ahmed Isam A. 
Published: December 2022

AbstractOlive (Olea europaea L.) has triacylglycerols, phenolics, and other antioxidants in its composition playing significant roles in maintaining health and reducing the onset of diseases. This study aimed to analyze the quality, antioxidant, textural profile, and sensory properties of processed Cheddar cheese fortified with 0%, 5%, 10%, 15%, and 20% (v/w) olive oil–whey protein isolate emulsion during 60 days of storage period. The results showed that processed cheese had significantly higher (p < .05) antioxidant activity, and total phenolic and flavonoids contents, whereas nonsignificant increase (p > .05) in moisture and acidity while decreasing tendencies in pH, fat, protein, and ash contents. Sensory analysis showed that processed Cheddar cheese with 5% emulsion had higher taste, aroma, texture/appearance, overall acceptability scores, and hardness. Conclusively, results indicated that olive oil–whey protein isolate emulsion could be beneficial for manufacturing and commercializing processed cheeses, analogs, or spreads with improved nutritional value and sensory characteristics.
Microfluidic Impedance Cytometry for Single‐Cell Particulate Inorganic Carbon:Particulate Organic Carbon Measurements of Calcifying Algae
Authors: de Bruijn Douwe S. , Van de Waal Dedmer B. , Helmsing Nico R. , Olthuis Wouter , van den Berg Albert 
Published: December 2022

AbstractCalcifying algae, like coccolithophores, greatly contribute to the oceanic carbon cycle and are therefore of particular interest for ocean carbon models. They play a key role in two processes that are important for the effective CO2 flux: The organic carbon pump (photosynthesis) and the inorganic carbon pump (calcification). The relative contribution of calcification and photosynthesis can be measured in algae by the amount of particulate inorganic carbon (PIC) and particulate organic carbon (POC). A microfluidic impedance cytometer is presented, enabling non‐invasive and high‐throughput assessment of the calcification state of single coccolithophore cells. Gradual modification of the exoskeleton by acidification results in a strong linear fit (R2 = 0.98) between the average electrical phase and the PIC:POC ratio of the coccolithophore Emiliania huxleyi 920/9. The effect of different CO2 treatments on the PIC:POC ratio, however, is inconclusive, indicating that there is no strong effect observed for this particular strain. Lower PIC:POC ratios in cultures that grew to higher cell densities are found, which are also recorded with the impedance‐based PIC:POC sensor. The development of this new quantification tool for small volumes paves the way for high‐throughput analysis while applying multi‐variable environmental stressors to support projections of the future marine carbon cycle.
Functionalized MoO3 Nanosheets for High‐Efficiency RhB Removal
Authors: Ma Yuxi , Wang Lifeng , Liu Dan , Liu Yuchen , Yang Guoliang , Qian Yijun , Lei Weiwei 
Published: December 2022

Abstract2D nanostructured materials have been applied for water purification in the past decades due to their excellent separation and adsorption performance. However, the functional 2D nanostructured molybdenum trioxide (MoO3)has rarely been reported for the removal of dyes. Here, functionalized MoO3 (F‐MoO3) nanosheets are successfully fabricated with a high specific surface area (106 cc g−1) by a one‐step mechanochemical exfoliation method as a highly effective adsorbent for removing dyes from water. According to the Raman, X‐ray photoelectron spectroscopy, Fourier transform infrared (FTIR), and selected area electron diffraction analysis, functional groups (hdroxyl groups, amide groups, amine groups and amino groups) are identified in the as‐prepared F‐MoO3 nanosheets. The attached functional groups not only facilitate the dispersal ability of F‐MoO3 nanosheets but also enhance the adsorption capacities. Thus, the performance (up to 556 mg g−1 when the initial concentration of Rhodamine B solution is 100 mg L−1) of as‐prepared F‐MoO3 nanosheets is almost two times higher than other reported MoO3 materials. Furthermore, the FTIR spectra, isotherm, and several factors (e.g., adsorbent dosage and adsorbate dosage) are also systematically investigated to explore the adsorption mechanism. Therefore, this work demonstrates that the F‐MoO3 nanosheets are a promising candidate for wastewater treatment.