bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the optimization of cooperative advertising strategy in the promotion of water-saving products based on differential game
Authors: Du Peijie , Zhang Shujing , Wang Han , Wang Yanrong 
Published: October 2022

Abstract
The promotion of water-saving products is one of the vital ways to implement water conservation action, and advertising is a significant way to promote water-saving products. Taking the two-level Supply Chain consisting of a leading manufacturer and a retailer as an example and considering the advertising cost-sharing ratio of the two, as well as the government's R&D subsidies to manufacturers and product subsidies to consumers, this study establishes differential game models in three cases, that is, non-cooperative contract without cost sharing, cooperative contract with cost sharing, and collaborative cooperation contract. Also, numerical simulation is adopted to analyze the sensitivity of important parameters. The results show that the product goodwill and market demand for water-saving products can achieve Pareto optimality under the collaborative cooperation contract. In addition, the cooperative contract with cost sharing can realize Pareto improvement of the optimal benefit of the Supply Chain under certain conditions. Moreover, in the absence of the government's R&D subsidies, the overall benefits can achieve Pareto optimality under the collaborative cooperation contract. This study provides theoretical guidance and reference for the advertising cooperation strategy for the main bodies in the Supply Chain.
Predictive modelling physico-chemical properties groundwater in coastal plain area of Vinh Linh and Gio Linh districts of Quang Tri Province, Vietnam
Authors: Nguyen Hong Giang , Tran Dinh Hieu , Hoang Ngo Tu Do , Nguyen Tien Thinh 
Published: October 2022

Abstract
This paper presents to study the performance of machine learning techniques consisting of multivariate adaptive regression spline (MARS), feed forward neural network-back propagation (FFNN-BP), and decision tree regression (DTR) for estimating the physico-chemical properties of groundwater in the coastal plain area in Vinh Linh and Gio Linh districts of Quang Tri province of Vietnam. With 290 groundwater samples collected in two districts, this study has identified three main elements CO2, Ca, CaCO3 for simulation. Quantitative analysis results have shown that these three components are such as CaCO3 with from 0 to 25.8 mg/l, Ca from 0 to 87.55 mg/l and CO2 from 0 to 12 mg/l. In the present examination, groundwater quality index (GQI) values and their representative categories have been referred by the Vietnam Groundwater Standard (QCVN01). Furthermore, the statistical accuracy parameters were used to compare among models. To deploy FFNN-BP and DTR, different types of transfer and kernel functions were tested, respectively. Determining the results of MARS, FFNN-BP and DTR showed that three models have suitable carrying out for forecasting water quality components. Comparison of outcomes of MARS model with the FFNN-BP and DTR models indicated that this model has good performance for forecasting the elements of water quality, its level of accuracy was slightly more than the other. To assess the accurate values of the models according to the measurement parameters for training phase illustrated that the order of the models was MARS to give the best result, followed by DTR and finally FFNN-BP, respectively.
Understanding short-term organic matter fluctuations to optimize drinking water treatment
Authors: Klante Clemens , Hägg Kristofer , Larson Magnus 
Published: October 2022

AbstractIncreases in organic content and the resulting browning of freshwater are a current and growing challenge for the ecology of these waters, leading to the need for more efforts in drinking water production. This study investigated the implications of short-term changes in the water quality from Lake Bolmen on the treatment process at the downstream located at the Ringsjö water treatment plant. The main objective was to understand short-term organic matter fluctuations to efficiently manage drinking water treatment. The ability to make predictions about expected raw water quality based on variations in the watershed and upstream waters facilitates optimal adjustment of drinking water treatment processes. Key elements in the water supply system studied included a tunnel and pipeline system and a sub-basin of Lake Bolmen. A wealth of data were available for the analysis to establish temporal and spatial properties of the water quality in the system and its dependence on the governing factors. The main factors controlling water quality were identified, both regarding the transport in the tunnel and through the sub-basin, including surface runoff, hydrodynamic properties, sedimentation, resuspension, and biomass availability. Although a particular case was investigated, the study has implications for improving drinking water treatment.
Melatonin in Reproductive Medicine: A Promising Therapeutic
Target?
Authors: Feng Xueqin , Zhang Yumeng , Li Na , Zhang Yingying , Zheng Qiutong , Sun Minya , Tang Jiaqi , Xu Zhice 
Published: October 2022

Abstract:
Melatonin, mainly released from the pineal gland, also produced in the reproductive
organs and cells, plays important roles in rhythms of the sleep-wake cycle, retardation
of ageing processes, and antioxidant/anti-inflammatory functions. As a key mediator
in reproductive systems, melatonin is participated in the reproductive process via regulating
gamete and embryo development and influences reproductive diseases and pregnancy
outcomes. The underlying mechanisms include epigenetic and other regulations,
which are interesting for exploring new targets in the prevention and treatment of reproductive
diseases. This review discusses the relationship between melatonin and reproductive
functions and dysfunction, as well as potential clinical applications of melatonin in
reproductive medicine. Notably, Developmental Origins of Health and Diseases (DOHaD)
is closely linked to reproduction, this article is the first to review the new progress
in studies on the possible relationship between melatonin and DOHaD.
HDAC3 Impairs Cardiac Function in Chronic Heart Failure Rats via
Mediating MicroRNA-26b-3p to Target High Mobility Group
AT-Hook 2
Authors: Han Xinyuan , Wang Shunda , Yong Zhijun , Zhang Xueting , Wang Xuanqi , Sun Chaofeng 
Published: October 2022

Background:
Histone deacetylase 3 (HDAC3) has been studied in chronic heart failure (CHF), while the regulatory mechanism of HDAC3 on the development of CHF though regulating microRNA (miR)-26b-3p/high mobility group AT-hook 2 (HMGA2) axis has not been extensively investigated. This study aimed to probe the effects of HDAC3, miR-26b-3p and HMGA2 on CHF.

Methods:
CHF rat models were established using aortic coarctation. Then the HDAC3, miR-26b-3p and HMGA2 levels in CHF rats were examined. Thereafter, the CHF rats were injected with relative oligonucleotides and plasmids of HDAC3, miR-26b-3p and HMGA2 to detect the cardiac function, inflammatory reaction, myocardial tissue pathological changes, and cardiomyocyte apoptosis. The binding relationship between miR-26b-3p and HMGA2 and the interaction between HDAC3 and miR-26b-3p were validated.

Results:
HDAC3 and HMGA2 were elevated while miR-26b-3p was decreased in CHF rats. The reduced HDAC3 or HMGA2 or enriched miR-26b-3p attenuated cardiac dysfunction, inflammatory reaction, myocardial tissue pathological changes and cardiomyocyte apoptosis in CHF rats, while the reduction of miR-26b-3p exerted the opposite effects. Furthermore, the inhibition of the miR-26b-3p or elevation of HMGA2 reversed the effect of reduced HDAC3 on mitigating CHF progression. Mechanically, miR-26b-3p targeted HMGA2 and HDAC3 bound to miR-26-3p.

Conclusion:
Downregulation of HDAC3 relieves cardiac function in CHF rats via mediating miR-26b-3p/HMGA2 axis. This study provides novel theory references and a distinct direction for the therapy strategies of CHF.
Nanoparticle-based CRISPR/Cas Delivery: An Emerging Tactic for
Cancer Therapy
Authors: Dilnawaz Fahima , Acharya Sarbari 
Published: October 2022

Abstract:
Genome editing arose as a new promising approach for treating numerous intricate
ailm ents including cancer. Over the past couple of decades, delivery technologies
that have serendipitously been developed using viral vectors are successful to some extent
in protein and nucleic acid delivery but their effectiveness still lags due to their efficiency,
tissue targeting capabilities, and toxicity which must be further improved. With
the infiltration of nanotechnology into every sphere of life, nano-vehicles can be implemented
as an ideal modality that can overcome challenges, also can be introspective as
new genome editing tools for cancer therapy owing to the safety and efficiency in clinical
settings. Such projected substitution can help in developing highly efficacious therapy
regimes which are successful in clinical settings. This emerging approach of incorporation
of genome editors (CRISPR/Cas) in different nano vehicles and their utility in targeting
various aspects of cancer therapy like treatment, diagnostics, modelling has been
comprehensively done in this review.
Potential for Novel Therapeutic Uses of Alpha Lipoic Acid
Authors: Fasipe Babatunde , Faria Andre , Laher Ismail 
Published: October 2022

Abstract:
Alpha-lipoic acid (ALA) is a potent antioxidant used in the management of diabetic
neuropathy due to its ability to prevent neuronal lipid peroxidation. ALA also chelates
transition metals, which can be beneficial in some diseases related to metal overload.
Due to its unique antioxidant properties, ALA has potential novel applications in
other diseases related to oxidative stress and inflammation. This review summarizes aspects
of recent clinical trials and describes the uses of ALA in managing neuropathies.
The unique pharmacological actions of ALA, coupled with relatively low toxicity, have
led to several trials on the potential therapeutic uses of ALA in the management of diseases
associated with increased oxidative stress, inflammation, and metal overload.
Novel Anti-Pseudomonas Cephalosporins
Authors: Chang M.H. , Koh H.Y. , Cho Y.S. , Choi K.I. 
Published: October 2022

Abstract:
Since the catechol type cephalosporins having a potent activity against P. aeruginosa strain were introduced, many kinds of derivatives have been developed. These cephalosporins adopted various substituents as siderophores such as catechol or pyridone type derivatives at C-7 or C-3 position to facilitate their penetration through the bacterial cell membrane. In this review, the structural specifications of the recently developed cephalosporins and their biological activity against P. aeruginosa bacterial strain would be overviewed.
Antiviral Nucleosides
Authors: Storer Richard , Mansour Tarek S. 
Published: October 2022

Abstract:
This article provides an overview of the field of nucleoside antiviral agents in so far as they have some level of current interest. It considers compounds in a number of structural classes: conventional nucleoside analogues, acyclics, carbocyclics, thio, heterosubstituted and those having "unnatural" L stereochemistry. In addition, it deals with important derivative subclasses such as phosphonate mimics of nucleotides. We indicate the current•status of leading compounds, which in many cases is clinical evaluation, and position with regard to licensing, and reflect the current level and style of activities within each particular class.
Our other major objective has been to incorporate a review of the major publications appearing in the last two years in the area of antiviral nucleosides. This includes both biological and clinical studies as well as the more significant advances in synthetic approaches to compounds in all classes. We refer extensively throughout to other relevant review articles which have covered particular areas -of investigation or have dealt in depth with a single compound.
Advances in Anti-metabolic Disease Treatments Targeting CD47
Authors: Wu Yonggui , Gao Li , He Zhe 
Published: October 2022

Abstract:
Metabolic disorders include a cluster of conditions that result from hyperglycemia, hyperlipidemia, insulin resistance, obesity, and hepatic steatosis, which cause the dysfunction of immune cells and innate cells such as macrophages, natural killer cells, vascular endothelial cells, hepatocytes, and human kidney tubular epithelial cells. Besides targeting the derangements in lipid metabolism, therapeutic modulations to regulate abnormal responses in the immune system and innate cell dysfunctions may prove to be promising strategies in the management of metabolic diseases. In recent years, several targets have been explored for CD47 molecule (CD47), a glycosylated protein, which was originally reported to transmit an anti-phagocytic signal known as “don’t eat me” in the atherosclerotic environment, hindering the efferocytosis of immune cells and promoting arterial plaque accumulation. Subsequently, the role of CD47 has been explored in obesity, fatty liver, and lipotoxic nephropathy and its utility as a therapeutic target has been investigated using anti-CD47 antibodies or inhibitors of the THBS1/CD47 axis and the CD47/SIRPα signaling pathway. This review summarizes the mechanisms of action of CD47 in different cell types during metabolic diseases and the clinical research progress to date, providing a reference for the comprehensive targeting of CD47 to treat metabolic diseases and the devising of potential improvements to possible side effects.
Discovery of Resveratrol and its Derivatives as Novel Antiviral and Anti-
Phytopathogenic-Fungus Agents
Authors: Yu Xiuling , Feng Feng , Wang Qingmin , Xia Zongwei , Song Pengfei , Yang Wenqiang , Wang Jiacai 
Published: October 2022

Background:
Plant diseases caused by viruses and pathogens have posed a serious threat to
global agricultural production and are difficult to control. Natural products have always been a valuable
source for lead discovery in medicinal and agricultural chemistry. The natural product resveratrol was
found to have good antiviral activity against the tobacco mosaic virus (TMV) and fungicidal activities
against 14 kinds of phytopathogenic fungi.

Objective:
The aim of this work was to design, synthesize a series of derivatives of resveratrol, and
evaluate their antiviral and fungicidal activities systematically.

Method:
Novel resveratrol sulfonate derivatives were prepared by a convenient synthesis method from
resveratrol, alkyl sulfonyl chloride, aryl sulfonyl chloride, and heterocyclic sulfonyl chloride. Their
structures were also identified by nuclear magnetic resonance (NMR) spectroscopy and high-resolution
mass spectrometry (HRMS).

Results:
Most of the targets were obtained at a high yield. Compounds I-2, I-5, I-10, II-2, and II-4, with
excellent antiviral activities, showed higher anti-TMV activities than those of lead compounds and
commercial ribavirin (inhibitory rates of 38, 37, and 38% at 500 μg/mL for inactivation, curative, and
protection activities in vivo, respectively). In particular, compounds I-5, I-10, II-2, and II-4 displayed
similar inhibitory effects as ningnanmycin (inhibitory rates of 54, 56, and 58% at 500 μg/mL for inactivation,
curative, and protection activities in vivo, respectively), the best antiviral agent at present,
thereby emerging as new antiviral pilot compounds. Further fungicidal activity tests showed that
resveratrol derivatives also displayed broad-spectrum fungicidal activities.

Conclusion:
The anti-TMV activities of these compounds were discovered for the first time. Some of
these simply structured compounds showed higher TMV inhibitory effects than ribavirin. The current
study provided valuable insights into the antiviral and fungicidal activities of resveratrol derivatives,
but more modification of the structure should be conducted.
Overview of Inorganic Nanoparticles: An Expanding Horizon in Tumor
Therapeutics
Authors: Kumar Lalit , Verma Shivani , Utreja Puneet , Kumar Dinesh 
Published: October 2022

Background:
Cancer is characterized by uncontrolled cell division in the human body
damaging normal tissues. There are almost a hundred types of cancers studied to date that are conventionally
treated with chemotherapy, radiation therapy, and surgery. Conventional methods have
drawbacks like non-specific distribution of drugs, low concentration of drugs in tumors, and adverse
effects like cardiotoxicity. Therefore, inorganic nanoparticles are explored nowadays to
achieve better results in cancer treatment.

Objective:
The objective of this review paper was to summarize the role of inorganic nanoparticles
in cancer treatment by revealing their preclinical status and patents.

Methods:
Literature survey for the present work was conducted by exploring various search engines
like PubMed, Google Scholar, and Google patents.

Results:
Inorganic nanoparticles come under the advanced category of nanomedicine explored in
cancer therapeutics. The structural properties of inorganic nanoparticles make them excellent candidates
for targeting, imaging, and eradication of cancer cells. Besides this, they also show high
biocompatibility and minimum systemic toxicity.

Conclusion:
This review paper concludes that inorganic nanoparticles may be better alternatives
to conventional approaches for the treatment of cancer. However, their presence in global pharmaceutical
markets will be governed by the development of novel scale-up techniques and clinical
evaluation.
Neuroprotective and Anti-Inflammatory Effects of Pioglitazone on
Parkinson's Disease: A Comprehensive Narrative Review of Clinical and
Experimental Findings
Authors: Zamanian Mohammad Yassin , Terefe Ermias Mergia , Taheri Niloofar , Kujawska Małgorzata , Tork Yekta Jahedi , Abdelbasset Walid Kamal , Shoukat Shehla , Catalan Opulencia Maria Jade , Heidari Mahsa , Alesaeidi Samira 
Published: October 2022

Abstract:
Parkinson's disease (PD) is a chronic and progressive neurological disorder characterized by
the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). The pathogenesis
of PD is strongly related to mitochondrial dysfunction, oxidative stress, and neuroinflammation.
This indicates that PD can be treated with anti-oxidative substitutes and anti-inflammatory compounds.
The neuroprotective and anti-inflammatory effects of peroxisome proliferator-activated receptor
γ (PPAR-γ) agonists decrease cell death and halt the increase in neurodegeneration, which is why
they have been given a lot of importance in research. Antidiabetic and anti-inflammatory effects have
been observed to be generated by pioglitazone (PG), a selective peroxisome proliferator-activated receptor
γ (PPAR-γ) agonist that regulates neural plasticity in various neurodegenerative disorders. The
neuroprotective and anti-inflammatory effects of PG are assessed in this article. It was found that the
patients with DM who received PG treatment were noticeably at a lower risk of PD. However, some
clinical studies have not proven a strong link between the therapeutic effects of PG on PD. As per
suggestions of preclinical studies, the therapeutic effects of PG treatment include; increased life expectancy
of neurons, decreased oxidative stress, halted microglial activity, lower inflammation (reduced
NF-κB, COX-2, and iNOS), reduced mitochondrial dysfunction, rise in motor function (motor agility)
and non-motor function (lowered cognitive dysfunction). In conclusion, we determined that PG exerts
neuroprotective and anti-inflammatory effects in PD models and it can be considered a potential therapeutic
candidate for PD.
The Protective Role of L-carnitine on Psychosocial Stress-induced Changes in Gene Expression and Protein Levels of Matrix Metalloproteinases, Serum Corticosterone in a Rat Model
Authors: Rababa’h Suzie Y. , Alzoubi Karem H. , Hammad Hana , AlQuraan Laiali , Rababa’h Abeer M. 
Published: October 2022

Background:Psychosocial stress (STS) is a common stress in modern societies. Chronic STS is associated with the impairment of a broad range of cognitive functions in humans and with prolonged abnormalities in memory. Matrix metalloproteinases (MMPs), a protein family of zinccontaining endopeptidases, are essential in neuro-inflammation and involved in neurodegenerative diseases. L-Car possessed neuroprotective, antioxidant, and anti-inflammatory properties and was shown to modulate MMPs.Objective:The current study aimed to examine the protective effect of L-Carnitine (L-CAR) on STSinduced changes in serum corticosterone levels, MMP-2, -9, and -12 protein and mRNA expression in the hippocampus as a possible mechanism for L-CAR protective effect on STS-induced memory impairment.Methods:The chronic STS and L-CAR (300 mg/kg/day, i.p) were simultaneously administered for 6 weeks to adult male Wistar rats. Serum corticosterone and protein levels of MMP-2, -9 and -12 were evaluated using ELISA. Real-Time PCR techniques were used to determine the mRNA levels of MMP-2, -9 and -12 in the hippocampus.Results:The findings showed that serum corticosterone levels and MMP-2 and -9 protein levels were significantly increased (p<0.05) in the STS group compared to the control. Similarly, RT-PCR findings showed that the mRNA of those proteinases significantly increased (p<0.05) following the intruder method. On the other hand, the administration of L-CAR restored the alterations in corticosterone levels and MMPs gene and protein expression induced by chronic STS.Conclusions:STS induced elevations in corticosterone and MMP-2 and -9 levels in the hippocampus. L-CAR, on the other hand, exhibited protective effects against the STS-induced changes in MMP-2 and -9.
Assessment of the Erosive Potential of Mineral Waters in Bovine Dental Enamel
Authors: Xavier Gabriela Monteiro Barbosa , De Almeida Aila Silva , de Souza Bentes Alexandra Gabrielly , Sano Issae Sousa , Silva Cecy Martins , Araújo Jesuína Lamartine Nogueira 
Published: October 2022

Background:
High intake of acidic foods and beverages has been often associated with the onset of dental erosive wear.

Objetive:
This study in vitro assessed the pH of different mineral waters marketed in Brazil and their effects on the properties and surface of dental enamel.

Methods:
Forty-eight bovine incisor specimens were divided into four groups (n=12): CG-control group, PeG-Perrier, PrG-Prata, and SLG-São Lourenço. The immersion cycles were performed after analysis of the pH of the waters, for 5 days (5 minutes in mineral water and 60 minutes in artificial saliva). Knoop micro-hardness was assessed by means of three indentations with a load of 50kgf for 15 seconds, and surface roughness with a cut off of 0.25mm. The data were analysed using Student's t-test, ANOVA, and Tukey test, with a significance level of 5%.

Results:
The groups of waters with lower pH (Perrier® and São Lourenço®) exhibited a reduction in Knoop micro-hardness (p<0.0001) and an increase in surface roughness (p=0.04 and p=0.004, respectively). The Prata water group did not exhibit significant changes in Knoop micro-hardness (p=0.07) and surface roughness (p=0.26).

Conclusion:
Mineral waters with a pH below the critical value can lead to a reduction in surface hardness and roughness in the bovine enamel.