bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-person feature fusion transfer learning-based convolutional neural network for SSVEP-based collaborative BCI
Authors: Li Penghai , Su Jianxian , Belkacem Abdelkader Nasreddine , Cheng Longlong , Chen Chao 
Published: July 2022

ObjectiveThe conventional single-person brain–computer interface (BCI) systems have some intrinsic deficiencies such as low signal-to-noise ratio, distinct individual differences, and volatile experimental effect. To solve these problems, a centralized steady-state visually evoked potential collaborative BCI system (SSVEP-cBCI), which characterizes multi-person electroencephalography (EEG) feature fusion was constructed in this paper. Furthermore, three different feature fusion methods compatible with this new system were developed and applied to EEG classification, and a comparative analysis of their classification accuracy was performed with transfer learning-based convolutional neural network (TL-CNN) approach.ApproachAn EEG-based SSVEP-cBCI system was set up to merge different individuals’ EEG features stimulated by the instructions for the same task, and three feature fusion methods were adopted, namely parallel connection, serial connection, and multi-person averaging. The fused features were then input into CNN for classification. Additionally, transfer learning (TL) was applied first to a Tsinghua University (THU) benchmark dataset, and then to a collected dataset, so as to meet the CNN training requirement with a much smaller size of collected dataset and increase the classification accuracy. Ten subjects were recruited for data collection, and both datasets were used to gauge the three fusion algorithms’ performance.Main resultsThe results predicted by TL-CNN approach in single-person mode and in multi-person mode with the three feature fusion methods were compared. The experimental results show that each multi-person mode is superior to single-person mode. Within the 3 s time window, the classification accuracy of the single-person CNN is only 90.6%, while the same measure of the two-person parallel connection fusion method can reach 96.6%, achieving better classification effect.SignificanceThe results show that the three multi-person feature fusion methods and the deep learning classification algorithm based on TL-CNN can effectively improve the SSVEP-cBCI classification performance. The feature fusion method of multi -person parallel feature connection achieves better classification results. Different feature fusion methods can be selected in different application scenarios to further optimize cBCI.
Double-dose icotinib may induce the emergence of the EGFR exon 20 T790M mutation in non-small cell lung cancer patients harboring EGFR-sensitive mutation
Authors: Chen Jianxin , Wu Xilin , Wang Junhui 
Published: July 2022

BackgroundAcquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) inevitably occurs in non-small cell lung cancer (NSCLC) patients harboring EGFR-sensitive mutations. There are approximately half of the patients who developed resistance to EGFR-TKIs treatment, the mechanism of which remains undiscovered. We occasionally found that double-dose icotinib as further-line salvage treatment may induce the emerging mutation of EGFR exon 20 T790M in NSCLC patients. The present study, therefore, was conducted to explore the probability of the emerging T790M mutation after exposure to double-dose icotinib in metastatic NSCLC patients.Patients and MethodsMetastatic NSCLC patients who received double-dose icotinib as salvage treatment after progression on first-generation TKIs and systematic chemotherapy were screened. Thereafter, patients who received a repeated next-generation sequencing (NGS) test with tumor sample were further enrolled. The procedure of NGS was performed with the standard criteria. Finally, the clinical characteristics, treatment procedures, and outcomes of eligible patients were reviewed and presented.ResultsThree patients have been detected with the emerging T790M mutation after double-dose icotinib exposure, with a mutation frequency of 19.6%, 8.2%, and 87.5%. During the treatment of targetable TKIs including almonertinib or osimertinib, partial response was observed in two patients, and stable disease was observed in the other. The progression-free survival by targetable TKIs for the patients was 3.7+ months (still in extension), 4.9+ months (still in extension), and 6.3 months. Manageable adverse events were observed during the treatment of TKIs.ConclusionThe results of the present study revealed that the emerging EGFR exon 20 T790M mutation might be induced by double-dose icotinib exposure in further-line treatment. Patients with the emerging T790M mutation responded well to the treatment of targetable TKIs including almonertinib or osimertinib.
NUT Carcinoma—An Underdiagnosed Malignancy
Authors: Lauer Ulrich M. , Hinterleitner Martina , Horger Marius , Ohnesorge Paul V. , Zender Lars 
Published: July 2022

NUT carcinoma (NC) is a rare and highly aggressive malignancy with a dismal prognosis and a median survival of 6–9 months only. Although very few cases of NC are reported each year, the true prevalence is estimated to be much higher, with NC potentially widely underdiagnosed due to the lack of awareness. NC primarily occurs in midline structures including thorax, head, and neck; however, other sites such as pancreas and kidney are also affected, albeit at lower frequencies. NC is characterized by a single translocation involving the NUTM1 (NUT midline carcinoma family member 1) gene and different partner genes. The resulting fusion proteins initiate tumorigenesis through a mechanism involving BET (bromo-domain and extra-terminal motif) proteins such as Bromodomain-containing protein 4 (BRD4) and inordinate acetylation of chromatin, leading to the dysregulation of growth and differentiation genes. While no clinical characteristics are specific for NC, some histologic features can be indicative; therefore, patients with these tumor characteristics should be routinely tested for NUTM1. The diagnosis of NC using immunohistochemistry with a highly specific antibody is straightforward. There are currently no standard-of-care treatment options for patients with NC. However, novel therapies specifically addressing the unique tumorigenic mechanism are under investigation, including BET inhibitors. This review aims to raise awareness of this underdiagnosed cancer entity and provide all patients the opportunity to be properly diagnosed and referred to a clinical study.
Partial Nephrectomy Versus Radical Nephrectomy for Endophytic Renal Tumors: Comparison of Operative, Functional, and Oncological Outcomes by Propensity Score Matching Analysis
Authors: Xiong Situ , Jiang Ming , Jiang Yi , Hu Bing , Chen Ru , Yao Zhijun , Deng Wen , Wan Xianwen , Liu Xiaoqiang , Chen Luyao , Fu Bin 
Published: July 2022

PurposeThe study aimed to compare operative, functional, and oncological outcomes between partial nephrectomy (PN) and radical nephrectomy (RN) for entophytic renal tumors (ERTs) by propensity score matching (PSM) analysis.MethodsA total of 228 patients with ERTs who underwent PN or RN between August 2014 and December 2021 were assessed. A PSM in a 1:1 ratio was conducted to balance the differences between groups. Perioperative characteristics, renal functional, and oncological outcomes were compared between groups. Univariate and multivariate logistic and Cox proportional hazard regression analyses were used to determine the predictors of functional and survival outcomes.ResultsAfter PSM, 136 cases were matched to the PN group (n = 68) and the RN group (n = 68). Patients who underwent RN had shorter OT, less EBL, and lower high-grade complications (all p &lt;0.05) relative to those who underwent PN. However, better perseveration of renal function was observed in the PN group, which was reflected in 48-h postoperative AKI (44.1% vs. 70.6%, p = 0.002), 1-year postoperative 90% eGFR preservation (45.6% vs. 22.1%, p = 0.004), and new-onset CKD Stage ≥III at last follow-up (2.9% vs. 29.4%, p &lt;0.001). RN was the independent factor of short-term (OR, 2.812; 95% CI, 1.369–5.778; p = 0.005) and long-term renal function decline (OR, 10.242; 95% CI, 2.175–48.240; p = 0.003). Furthermore, PN resulted in a better OS and similar PFS and CSS as compared to RN (p = 0.042, 0.15, and 0.21, respectively). RN (OR, 7.361; 95% CI, 1.143–47.423; p = 0.036) and pT3 stage (OR, 4.241; 95% CI, 1.079–16.664; p = 0.039) were independent predictors of overall mortality.ConclusionAmong patients with ERTs, although the PN group showed a higher incidence of high-grade complications than RN, when technically feasible and with experienced surgeons, PN is recommended for better preservation of renal function, longer OS, and similar oncological outcomes.
Online assessment of narrative macrostructure in adult Irish-English multilinguals
Authors: Antonijevic Stanislava , Colleran Sarah , Kerr Clodagh , Ní Mhíocháin Treasa 
Published: July 2022

BackgroundOnline assessment of narrative production and comprehension became an important component of language assessment during the COVID-19 pandemic. This study aimed to establish quantitative measures of narrative macrostructure in the production and comprehension of adult Irish-English bilinguals in an online assessment.MethodsA total of 30 Irish-English bilingual adults participated in an online assessment of oral narrative production and comprehension. Narratives were elicited using LITMUS-MAIN for Irish and English. Story-tell elicitation method was used for all stories. Twenty participants produced Baby Birds and Baby Goats story pairs while 10 participants produced Cat and Dog story pairs. Quantitative measures of story structure, comprehension score, and the overall number of Internal State Terms (ISTs) in production and comprehension were compared across the story pairs, languages, and the output type (production vs. comprehension).ResultsA general linear model indicated no differences in either story structure or story comprehension scores across languages for both sets of stories. Combined analysis for all participants and stories indicated no difference in the story structure scores or comprehension scores across the languages or the story pairs. While the overall number of ISTs was the same across languages, a higher number of ISTs was observed in comprehension relative to production in both languages for Cat and Dog story pair only, but not for Baby birds and Baby goats' stories. The major benefit of using online assessment was the accessibility of participants. The major drawback was the inability to control the environment and the quality of the internet connection.Conclusion and implicationsWhile online assessment increased the availability of participants, which is a significant factor in rural Ireland characterized by low population density and the high percentage of Irish speakers, the availability of stable internet connection limited the applicability of online assessment. Measures of narrative macrostructure were stable across the languages and the story pairs. This is important because of high variability in exposure to Irish, frequent code-switching, and a high number of morphosyntactic errors due to rapid language change that characterizes Irish-English bilinguals. Identifying reliable measures of language performance for Irish-English adult speakers is an important step toward establishing developmental norms for Irish-English bilinguals.
Altered voxel-mirrored homotopic connectivity in right temporal lobe epilepsy as measured using resting-state fMRI and support vector machine analyses
Authors: Chu Yongqiang , Wu Jun , Wang Du , Huang Junli , Li Wei , Zhang Sheng , Ren Hongwei 
Published: July 2022

BackgroundPrior reports revealed abnormalities in voxel-mirrored homotopic connectivity (VMHC) when analyzing neuroimaging data from patients with various psychiatric conditions, including temporal lobe epilepsy (TLE). Whether these VHMC changes can be leveraged to aid in the diagnosis of right TLE (rTLE), however, remains to be established. This study was thus developed to examine abnormal VMHC findings associated with rTLE to determine whether these changes can be used to guide rTLE diagnosis.MethodsThe resultant imaging data of resting-state functional MRI (rs-fMRI) analyses of 59 patients with rTLE and 60 normal control individuals were analyzed using VMHC and support vector machine (SVM) approaches.ResultsRelative to normal controls, patients with rTLE were found to exhibit decreased VMHC values in the bilateral superior and the middle temporal pole (STP and MTP), the bilateral middle and inferior temporal gyri (MTG and ITG), and the bilateral orbital portion of the inferior frontal gyrus (OrbIFG). These patients further exhibited increases in VMHC values in the bilateral precentral gyrus (PreCG), the postcentral gyrus (PoCG), and the supplemental motor area (SMA). The ROC curve of MTG VMHC values showed a great diagnostic efficacy in the diagnosis of rTLE with AUCs, sensitivity, specificity, and optimum cutoff values of 0.819, 0.831, 0.717, and 0.465. These findings highlight the value of the right middle temporal gyrus (rMTG) when differentiating between rTLE and control individuals, with a corresponding SVM analysis yielding respective accuracy, sensitivity, and specificity values of 70.59% (84/119), 78.33% (47/60), and 69.49% (41/59).ConclusionIn summary, patients with rTLE exhibit various forms of abnormal functional connectivity, and SVM analyses support the potential value of abnormal VMHC values as a neuroimaging biomarker that can aid in the diagnosis of this condition.
Application of “mosiac sign” on T2-WI in predicting the consistency of pituitary neuroendocrine tumors
Authors: Nie Ding , Zhao Peng , Li Chuzhong , Liu Chunhui , Zhu Haibo , Gui Songbai , Zhang Yazhuo , Cao Lei 
Published: July 2022

PurposeTumor consistency is important for pituitary neuroendocrine tumors (PitNETs) resection to improve surgical outcomes. In this study, we evaluated the T2-WI of PitNETs and defined a specific T2-WI signaling manifestation, the “Mosaic sign,” to predict tumor consistency and resection of PitNETs.DesignA retrospective review of MRI and tumor histology of 137 consecutive patients who underwent endoscopic endonasal resection for PitNETs was performed.MethodsThe “Mosaic sign” was defined by the ratio of the tumor itself T2-WI signals, and characterized by multiple intratumor hyperintense dots. The degree of tumor resection was an assessment by postoperative MRI examination. The presence of the “Mosaic sign” was compared with patients' basic information, tumor consistency, tumor pathological staining, and surgical result. To determine whether the presence or absence of “Mosaic sign” could predict tumor consistency and guide surgical resection of tumors.ResultsStatistical analysis showed that the consistency of the tumor and the degree of resection were correlated with the “Mosaic sign”. In the 137 cases of T2-WI, 43 had “Mosaic sign”, 39 cases had soft tumor consistency, and 4 were classified as fibrous, of which 42 were completely resected and 1 was subtotal resected. Of the 94 patients without “Mosaic sign”, the consistency of tumor of 54 cases were classified as soft, the remaining 40 cases were fibrous, 80 cases were completely resected, and 14 cases were subtotal resected. Postoperative cerebrospinal fluid leakage occurred in 1 patient. The number of corticotroph adenomas in the group of “Mosaic sign” was higher, with the statistical difference between the two groups (P = 0.0343).ConclusionsThe presence of the “Mosaic sign” in T2-WI may provide preoperative information for pituitary adenomas consistency and effectively guide surgical approaches.
Effect of regional anesthesia on the postoperative delirium: A systematic review and meta-analysis of randomized controlled trials
Authors: Li Tao , Dong Tiantian , Cui Yuanshan , Meng Xiangrui , Dai Zhao 
Published: July 2022

ObjectivePostoperative delirium (POD) starts in the recovery room and occurs up to 5 days after surgery. However, the POD guidelines issued by the European Society of Anesthesiology (ESA) suggest that the effect of regional anesthesia on POD is controversial. This meta-analysis aims to investigate whether perioperative regional anesthesia reduced the incidence of POD.MethodsStandard Published randomized controlled trails (RCTs) were searched from bibliographic databases to identify all evidence that reported regional anesthesia assessing incident delirium following diverse surgeries. The primary outcome was the incidence of POD, and the secondary outcomes were POD scores, pain scores, and emergence time. The relative risk (RR) for dichotomous outcomes and the weighted or standardized mean difference (WMD, SMD) for continuous outcomes were estimated using a random-effects model.ResultsTwenty RCTs with 2110 randomized participants undergoing different surgeries were included. Meta-analysis showed that regional anesthesia was associated with less POD incidence compared to general anesthesia (total intravenous anesthesia (TIVA) or inhalation anesthesia) (relative risk (RR) = 0.62, 95% confidence interval (CI) = 0.45–0.85)). Subgroup analysis showed that the decrease in POD incidence was associated with a nerve block (0.46, 95% CI = 0.32–0.67) and regional-combined-general anesthesia (0.42, 95% CI = 0.29–0.60). Regional anesthesia significantly reduced POD incidence in the recovery room after pediatric surgeries (0.41, 95% CI = 0.29–0.56). Regional anesthesia also reduced the POD score (SMD −0.93, 95% CI = −1.55 to −0.31) and pain score (SMD −0.95, 95% CI = −1.72 to −0.81). There was no significant difference in emergence time between regional anesthesia and general anesthesia (WMD −1.40, 95% CI = −3.83 to 6.63).ConclusionsThere was a significant correlation between regional anesthesia and the decrease in POD incidence, POD score, and pain score.
Internacionalización de las universidades peruanas para la integración y desarrollo sostenible
Authors: Auris Villegas David , Vilca Arana Miriam , Cisneros Flores Arístida Rufina , Valera Chota Candy , Espino Wuffarden Eugenio 
Published: July 2022

El ensayo analizó y propuso la necesidad de internacionalización de las universidades peruanas para su integración y desarrollo sostenible en el contexto de globalización tecnológica. El objetivo del ensayo fue plantear las formas de internacionalizar la educación superior. Se abordó la problemática del ecosistema de la educación universitaria, anclado en un hermetismo, limitaciones al exterior, causando subdesarrollo y aislamiento. La tesis central propuesta es volcar la política estatal y pedagógica universitaria hacia la internacionalización para lograr mayor integración en el mundo, desarrollando la capacidad humana y la competitividad. La metodología de esta investigación se elaboró desde el enfoque cualitativo, analítico, crítico y propositivo. Concluimos que las universidades y el estado deben asumir la responsabilidad y el compromiso, a través de múltiples mecanismos como, políticas internacionales, transferencia tecnológica, cooperación curricular y convivencia intercultural.
PENDIDIKAN TOLERANSI DALAM KELUARGA BEDA AGAMA DI DESA KAYUKEBEK KECAMATAN TUTUR KABUPATEN PASURUAN
Authors: Misbah M Islahuddin , Yusuf Achmad , Wijaya Yusuf 
Published: July 2022

Keragaman agama di Indonesia merupakan sunnatullah yang harus disyukuri. Selain itu keragaman agama terkadang menjadi sebuah permasalahan, seperti yang terjadi pada saat bom Gereja di Surabaya yang menimbulkan korban banyak. Masyarakat Indonesia perlu ditanamkan pendidikan toleransi beragama sejak dini. Pendidikan toleransi beragama sendiri adalah proses usaha seseorang dalam membangun kesadaran untuk menerima, menghormati, menghargai pandangan, keyakinan, perilaku dan praktik keagamaan orang lain yang berbeda dengan pendirian sendiri dalam rangka membangun kehidupan bersama dan hubungan sosial yang lebih baik. Dalam keluarga beda agama di Desa Kayukebek Kecamatan Tutur Kabupaten Pasuruan, pendidikan toleransi beragama merupakan solusi terbaik untuk menyelamatkan konflik yang terjadi karena perbedaan pandangan, keyakinan, perilaku dan praktik keagamaan dengan anggota keluarga ataupun orang lain.
Adapun hasil penelitian ini adalah 1) Nilai-nilai pendidikan toleransi dalam keluarga beda agama di Desa Kayukebek Kecamatan Tutur Kabupaten Pasuruan itu meliputi menghormati, menghargai, tolong-menolong, bekerjasama, persamaan, keadilan, kebebasan dan tanggung jawab. 2) Pelaksanaan pendidikan toleransi dalam keluarga beda agama di Desa Kayukebek Kecamatan Tutur Kabupaten Pasuruan itu menggunakan metode nasehat, keteladanan, pembiasaan, latihan, dan hukuman. Semua pelaksanaan pendidikan toleransi di keluarga beda agama tersebut di dalamnya sudah ada beberapa nilai pendidikan toleransi beragama seperti di atas.
IMPLEMENTASI GERAKAN SHALAT FARDLU SEBAGAI MOTIVASI ASPEK KESEHATAN
Authors: Kosim Nur , Hadi Muhammad Nur 
Published: July 2022

Shalat fardu adalah salah satu bentuk ibadah utama yang diperintah oleh agama yang harus dilaksanakan secara kontinyu (istqomah) oleh seorang hambah. Selain itu shalat tidak hanya menjadi amalan utama di akhirat nanti, tetapi ternyata gerakan-gerakan shalat adalah gerakan paling proporsional bagi anatomi tubuh manusia.
Berdasarkan latar belakang tersebut, penulis melakukan penelitian dengan hasil analisis data yang di pakai di lapangan, penulis dapat mengambil kesimpulan sebagai berikut. (1) Perencanaan implemenasi gerakan shalat Fardlu sebagai aspek motivasi kesehatan siswa telah dilakukan oleh kepala sekolah dan dewan guru. Mereka melakukan musyawarah sebelum ajaran baru dimulai. Hasil musyawarah adalah kegiatan shalat Dhuhur di laksanakan pagi hari shalat dhuha dan sebelum pulang anak-anak melakukan shalat dhuhur dengan berjamaah. (2) Implementasi gerakan shalat Fardlu sebagai motivasi aspek kesehatan siswa diaksanakan seelah kegiatan belajar mengajar di kelas. Saat waktunya shalat Dhuhur, baik guru maupun siswa melaksanakan shalah Dhuhur berjamaah. Selain itu, saat menjelaskan materi kurikulum Fikih tentang shalat, guru juga memaparkan pentingnya gerakan shalat bagi kesehatan manusia. Hal ini memberikan semangat siswa untuk rajin melaksanakan shalat Dhuhur berjamaah di Madrasah. (3) Faktor pendukung implementasi gerakan shalat sebagai motivasi aspek kesehatan adalah sumber daya manusia baik guru maupun siswa semangat dalam melaksanakan shalat Dhuhur berjamaah. Sarana dan prasana berupa mushallah sangat mendukung kegiatan tersebut.
ANALISIS FAKTOR FAKTOR YANG MENYEBABKAN KREDIT BERMASALAH PADA KOPERASI SERBA USAHA (KSU) SYARIAH PERMATA BARAKAH PURWOSARI
Authors: Maulidatul K  , Aslikhah  
Published: July 2022

Semakin berkembangnya kegiatan koperasi dapat dilihat dari jumlah anggota koperasi dan seberapa banyak perputaran uang yang sudah memfasilitasi anggotanya, Sehingga sudah sepantasnya koperasi yang berkembang harus selalu meningkatkan kemampuannya dalam mentransformasikan diri sesuai dengan perubahan-perubahan yang terjadi di dalam perekonomian. Sudah banyak contoh koperasi yang gagal dan akhirnya mengalami penutupan karena pengelolaan yang tidak professional. Hal ini kebanyakan disebabkan karena kelalaian dari dalam koperasi, kurangnya anggota yang bergabung dengan koperasi tersebut dan tidak seimbangnya antara pengeluaran kredit dan pemasukan dana berupa tabungan maupun pembayaran kredit tersebut.
Penelitian ini bertujuan untuk mengetahui faktor- faktor yang menyebabkan kredit bermasalah pada Koperasi Serba Usaha (KSU) Syari’ah Permata Barokah Purwosari .Penelitian ini menggunakan penelitian kualitatif dengan metode observasi, wawancara, dan dokumentasi.
Pada Koperasi Serba Usaha Permata Barakah sistem peminjaman yang membedakan dengan lembaga yang lain adalah koperasi ini hanya mencari nasabah pekerja pabrik atau yang lain yang mempunyai bayaran lewat ATM, kecuali nasabah yang mempunyai usaha yang lain dan mempunyai Akta Jual Beli.
Dan faktor- faktor yang paling dominan yang menyebabkan kredit bermasalah yaitu karena saldo yang ada di ATM kosong. Sehingga ketika petugas koperasi ingin melakukan penarikan uang sebagai angsuran tidak bisa.