bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative Determination of Pitavastatin in Tablets Using FTIR and
RP-HPLC Analysis: A Comparative Study
Authors: AlKadi Hourieh , Alzier Ali , Mando Huda , Mando Zaynab , Darwicha Jamal Abdul Naser , Allaf Abdul Wahab 
Published: May 2022

Background:
Fourier Transform Infrared (FTIR) spectroscopy and reverse phase highperformance
liquid chromatography, RP-HPLC analysis have been used for the quantitative determination
of local l commercially available Pitavastatin products.

Methods:
The FTIR method of analysis is not widely used in pharmaceutical quality control laboratories.
This technique is non-destructive, reliable, precise, and efficient, and the samples can be prepared
easily. These features emphasized that the FTIR technique can be considered as a potential analytical
method for quantitative analysis in pharmaceutical laboratories.

Results:
It is strongly recommended that FTIR analytical method can be applied simultaneously with
RP-HPLC techniques for quality control purposes of drug analysis. Both methods of analysis have
shown comparable precision and good repeatability and reproducibility for analysis of Pitavastatin
which can be generalized for other pharmaceutical products.

Conclusion:
In addition, FTIR is not only used for the determination of vibrational modes and structure
in the fingerprint region, but it can be also generally applied in quantitative analysis for many
pharmaceutical products.
Mucormycosis in India: Pathophysiology and Perspectives on Treatment
and Management
Authors: Gupta Utsav , Paliwal Deepika , Rawat Samridhi 
Published: May 2022

Abstract:
Mucormycosis, also known as "black fungus," is a potentially fatal disorder that causes
blurred or double vision, chest pain, and breathing problems. The introduction of novel risk factors and
causative agents, as well as the problems with controlling the disease, are all significant problems with
mucormycosis in India. It is most common among COVID-19 patients. Mucormycosis is an invasive
fungal disease that primarily affects immunosuppressant patients, mainly caused by mold fungi of the
genus mucor, rhizopus, rhizomucor, and absidia, which are in the zygomycetes class and the Mucorales
order. The most common risk factor is diabetes mellitus, followed by haematological malignancy
and solid-organ transplantation. Reversal of underlying predisposing factors, surgical debridement
of infected tissues, and proper antifungal therapy are all required for the treatment of mucormycosis.
In this review, the epidemiology, pathogenesis, and symptoms of black fungus and its
association with covid-19, treatment, and diagnosis are discussed.
Electro-Chlorination Technology for Disinfection of Drinking Water: A
Patent Landscape
Authors: Shinde Sapna R. , Apte Sayali , Tiwari Amit Kumar 
Published: May 2022

Abstract:
The Sustainable Development Goals (SDG) 2015, which are defined to achieve an improved and more sustainable future, promote safe and affordable drinking water facilities for all, till
2030. The rural and remotely placed population worldwide faces the problem of a shortage of pathogen-free drinking water due to the huge capital and maintenance costs involved in water purification. The current chemical disinfection treatment which is widely used for water disinfection has
several disadvantages including the formation of Disinfection By-Products (DBPs). Electrochlorination is one of the best alternatives as per the literature that can be installed as a decentralized
system in a remote location and can overcome most of the issues related to chemical disinfection.
The present paper provides an overview of the innovations in the area of electro-chlorination as a
disinfection technique through a detailed patent analysis. The patenting activity and publications are
considered an indicator of research and innovation in the field. The patent analysis is also supported
by literature analysis for understanding the research trends and the extent of research in the area.
The patent data from the year 2000 to 2021 are analyzed country-wise and year-wise. The paper also
discusses the IPC, CPC codes, assignees, investors, US class codes, patents types, and citations
analysis for the patents in the field of electro-chlorination and DBPs. The keywords used for patent
analysis are ‘Electro- chlorination’ and ‘Water’ and ‘Disinfection’ and ‘Disinfection by Products’.
Antihypertrophic Effect of Menthol from Mentha x Piperita Concerning
Cardiac Hypertrophy: A Review
Authors: Doss Victor Arokia , Nagarajan Anitha 
Published: May 2022

Background:
The abnormal enlargement or thickening of the heart muscle leads to diminishment of ventricular wall tension which helps to keep up the outstanding task at hand in terms of capacity and effectiveness. There are two kinds of hypertrophy: physiological and pathological. Initially, what evolves as an adaptive reaction, advances to heart failure. Different cellular signaling pathways control each type of hypertrophy. Peppermint - Mentha x piperita, a hybrid of Mentha spicata and Mentha aquatica belongs to the family of Lamiaceae. The peppermint oil has high menthol content and has many useful targets in cardiovascular disorders, such as hypertension, coronary heart disease, etc.,

Objective:
The objective of this review article is to investigate the antihypertrophic activity of Mentha x piperita which is not yet established

Methods:
For manuscript preparation, we had used all accessible international databases, traditional books (Regular books in English), and electronic resources (Google Scholar, PubMed, Science Direct, Springer, Wiley, etc.,), unpublished data (thesis, R&D reports, and dissertations).

Results:
Menthol may activate Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRMP8) channels resulting in increased cytosolic calcium concentration and vasorelaxation activity. Menthol is known to stimulate the elevation of TRPM8 protein in the endothelium, Vascular Smooth Muscle (VSM), and vascular afferent nerve strands, while obstructing VSM L-type Calcium Channels (LCC), contributing to both the cardiovascular and vasoactive properties of peppermint. In vivo experiments proved that glucagon plays a significant role in the preventive effect of menthol (as TRPM8 modulator) against a high-fat diet (HFD) induced weight gain and related complications.

Conclusion:
Due to the efficacy of Menthol (Mentha x piperita) in its cardioprotective properties, understanding the actual mechanisms related to the efficacy of Menthol on CVD can be the subject of future studies.
Application of grand techno-economic strategy based on linear programming in the textile industry
Authors: Harianto Raden Achmad , Sari Pratiwi Nila 
Published: May 2022

The main objective of this paper is to review of the evolution of management science, overview of grand strategy and its linkage with the techno – economic as a tactics to trigger productivity to win global competition. A review of the relevant literature was conducted and a connection between management science, grand strategy and techno – economic based on the linear programming can be applied in the textile industry. It was found that the industrial world in the midst of the Covid-19 pandemic has an impact on the market which is increasingly shrinking and is plagued by a quite severe sluggishness. Simultaneously the labor productivity is getting weaker. This is what is known as the negative impact of the global financial crisis. Will the Indonesian nation be able to maintain the momentum of economic growth amidst the tsunami waves of the global financial crisis? A grand strategy that combines the roles of technology and economy (techno-economic) strategy based on linear programming needs to be implemented immediately. The success of the techno economic strategy cannot be separated from the role of three pillars, namely mastery of technology, productivity and competitiveness.
PENGEMBANGAN E-LKPD BERBASIS ANDROID DENGAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING (PBL) UNTUK MENINGKATKAN BERPIKIR KRITIS
Authors: Fitriyah Ika Melina Nur , Ghofur Muhammad Abdul 
Published: May 2022

Abstrak: Tujuan penelitian ini yaitu untuk mengetahui peningkatan berpikir kritis peserta didik dengan menggunakan model pembelajaran PBL. Model problem based learrning digunakan untuk merangsang berpikir kritis dalam situasi berorientasi berbasis masalah. Model pengembangan penelitian ini adalah model pengembangan 4D (Define, Design, Development, Disseminate). Desain penelitian menggunakan pretest-posttest control group design. Subjek penelitian sebanyak 36 peserta didik di SMA Negeri 1 Bangil. Hasil penelitian yaitu bahwa pada kelas ekperimen dengan penerapan model problem based learning mengalami kenaikan, dengan hasil uji gain score bahwa pada kelas ekperimen dalam kriteria sedang. Sedangkan pada kelas kontrol juga mengalami kenaikan dalam berpikir kritis, dengan hasil uji gain score dalam kriteria rendah. Hasil respons siswa terhadap penggunaan E-LKPD ini dengan kriteria sangat baik. E-LKPD berbasis android diharapkan dapat mendorong siswa dalam memotivasi semangat dalam belajar.Abstract: The purpose of this study is to determine the increase in thinking critical of students by using the PBL learning model. The model is problem based learning used to stimulate critical thinking in problem-based oriented situations. The development model of this research is a 4D development model (Define, Design, Development, Disseminate). The research design used a pretest-posttest control group design. The research subjects were 36 students at SMA Negeri 1 Bangil. The result of the research is that the experimental class with the application of the model problem based learning has increased, with the test results gain score that the experimental class has moderate criteria. while the control class also experienced an increase in critical thinking, with the test results gain score in low criteria. The results of student responses to the use of E-LKPD with very good criteria. based E-LKPD is Android expected to encourage students to motivate enthusiasm in learning.
Level kemampuan metakognitif siswa dalam pembelajaran matematika berdasarkan gaya kognitif
Authors: Zakiah Nur Eva 
Published: May 2022

Tujuan penelitian adalah untuk mendeskripsikan level kemampuan metakognitif siswa berdasarkan gaya kognitif (Field Dependent or FD dan Field Independent or FI). Subjek penelitian adalah siswa kelas X (n = 33) salah satu SMA Negeri di Kabupaten Ciamis Provinsi Jawa Barat. Selanjutnya subjek dikelompokkan berdasarkan kategori Kemampuan Awal Matematis (KAM) (tinggi, sedang, dan rendah). Penelitian ini merupakan penelitian deskriptif menggunakan pendekatan kuantitatif dan kualitatif. Pengumpulan data menggunakan tes untuk menentukan level kemampuan metakognitif siswa dan Group Embedded Figure Test (GEFT) untuk mengklasifikasikan gaya kognitif siswa. Hasil penelitian menunjukkan bahwa: (1) level kemampuan metakognitif siswa dengan KAM tinggi untuk gaya belajar FD dan FI adalah reflective use; (2) level kemampuan metakognitif siswa dengan KAM sedang dengan gaya kognitif FD adalah strategic use, sedangkan FI adalah reflective use; dan (3) level kemampuan metakognitif siswa dengan KAM rendah dengan gaya kognitif FD adalah aware use, sedangkan FI adalah strategic use. The level of students' metacognitive ability in learning mathematics based on cognitive stylesAbstractThe research objective was to describe the level of students’ metacognitive ability based on cognitive style (Field Dependent or FD and Field Independent or FI). The research subjects were tenth-grade students (n = 33) at a public senior high school in Ciamis Regency, West Java Province. Furthermore, the subjects were grouped based on the Initial Mathematical Ability (IMA) category (high, medium, and low). This research was a descriptive study using quantitative and qualitative approaches. Data collection used a test to determine the level of students’ metacognitive ability and the Group Embedded Figure Test (GEFT) to classify students’ cognitive styles. The results showed that: (1) the level of students’ metacognitive ability with high category of IMA for the cognitive style of FD and FI was reflective use; (2) the level of students’ metacognitive ability with medium category of IMA for the cognitive style of FD was strategic use, while FI was reflective use; and (3) the level of students’ metacognitive ability with low category of IMA for the cognitive style of FD was aware use, while FI was strategic use.
Changes in Resilience Following Engagement With a Virtual Mental Health System: Real-world Observational Study
Authors: Graziani Grant , Aylward Brandon S , Kunkle Sarah , Shih Emily 
Published: May 2022

Background
Digital health services can serve as scalable solutions to address the growing demand for mental health care. However, more research is needed to better understand the association between engagement with care and improvements in subclinical outcomes.

Objective
This study aims to fill this research gap by examining the relationship between members’ engagement with the Ginger platform and changes in their psychological resilience.

Methods
We conducted a retrospective observational study of 3272 members who accessed Ginger, an on-demand mental health service, between January 2021 and November 2021. Each member completed the 10-item Connor-Davidson Resilience Scale questionnaire, a measure of psychological resilience, at baseline and again during a 6- to 16-week follow-up window. Depression and anxiety symptoms (9-item Patient Health Questionnaire and 7-item Generalized Anxiety Disorder) were also measured. Linear regression was used to identify the association between engagement with Ginger’s multiple care modalities and changes in resilience. Moderator analysis was conducted to test whether clinical depression or anxiety at baseline moderated the relationship between engagement level and changes in resilience.

Results
Of the 3272 members, 2683 (82%) reported low resilience at baseline. The mean change in resilience was 0.77 (SD 5.50) points. Linear regression models showed that age and census region did not predict changes in resilience; however, male members showed larger improvements (coefficient=0.58; P=.04). Baseline mental health outcomes, including resilience and depression and anxiety symptoms, were strong predictors of changes in resilience. Every point decrease in baseline resilience is associated with a 0.28-point increase in change in resilience (P<.001), and members with no or mild depression and anxiety at baseline saw changes in resilience that were 1.44 points (P<.001) larger than their clinical counterparts. Engagement with the Ginger system predicted changes in resilience. Members who engaged with Ginger coaching, clinical services, or both improved their resilience by 1.82, 1.55, and 1.40 points, respectively (P<.001), more than those who only engaged with Ginger content. Screening negative for moderate to severe depression and anxiety at baseline was associated with larger improvements in resilience (coefficient=1.30; P<.001); however, subclinical status was not shown to be a moderator for the association between level of engagement and changes in resilience.

Conclusions
Engagement with Ginger services was associated with improvements in resilience. Members who engaged in coaching or clinical care had significantly larger improvements compared with those who only engaged in self-guided content, regardless of whether a member screened positive for clinical depression or anxiety at baseline.
Supporting People Who Have Lost a Close Person by Bereavement or Separation: Protocol of a Randomized Controlled Trial Comparing Two French-Language Internet-Based Interventions
Authors: Debrot Anik , Kheyar Maya , Efinger Liliane , Berthoud Laurent , Pomini Valentino 
Published: May 2022

Background
Internet-based interventions (IBIs) are as efficient as face-to-face psychotherapy for a variety of mental health disorders, including complicated grief. Most evidence stems from guided IBIs. However, recent research indicates that the benefit of guidance is lower in more interactive IBIs. As such, providing guidance only to people requiring it (guidance on demand) appears a cost-effective solution. This is particularly important to develop given the recent rise in grief symptoms in the context of the COVID-19 pandemic. This paper presents the protocol of a randomized controlled trial comparing the efficacy and adherence rate of 2 IBIs for grief-related symptoms after the loss a close one following death or romantic separation, using a guidance on demand framework. LIVIA 2.0 was developed based on theoretical and empirical findings on grief processes and IBIs, and it will be compared to LIVIA 1 that has already demonstrated its efficacy.

Objective
Our main hypotheses are that LIVIA 1 (control condition) and LIVIA 2.0 (experimental condition) increase participants’ well-being and decrease their distress at posttest and at follow-up, that LIVIA 2.0 is more efficient than LIVIA 1 for all outcomes, and that LIVIA 2.0 has less dropouts than LIVIA 1.

Methods
Outcomes will be assessed at pretest, posttest (12 weeks later), and follow-up (24 weeks later). We will recruit 234 participants through a variety of means, including social media and contacts with the press. Primary outcomes are grief symptoms, depressive symptoms, and eudemonic well-being. Secondary outcomes are anxiety symptoms, grief coping strategies, aspects related to self-identity reorganization, and program satisfaction. LIVIA 2.0 participants will additionally undergo a weekly mood and grief symptom monitoring, allowing us to explore the short-term efficacy of the sessions.

Results
The creation and development of the content of LIVIA 2.0 was completed during the first phase of the project. Participant recruitment will begin in May 2022 and will last until January 2023.

Conclusions
This study will emphasize the relevance of the innovations included in LIVIA 2.0 regarding the efficacy and dropout rate of IBIs for grief symptoms and will allow investigations on how these changes impact the demand for guidance. In the current postpandemic times, developing and assessing IBIs targeting grief symptoms are particularly critical given the rise in grief-related symptoms.

Trial Registration
clinicaltrials.gov NCT05219760; https://tinyurl.com/3dzztjts

International Registered Report Identifier (IRRID)
PRR1-10.2196/39026
Utilization of Autoplay to Develop Excretion System as Learning Media with Engklek Game Evaluation
Authors: Anantyarta Primadya , Wicaksono Azizul Ghofar Candra 
Published: May 2022

The use of interactive multimedia as learning media is necessary to assist the learning process. The use of Autoplay in developing learning media enables the teachers to produce very good media in facilitating students' needs in learning excretory system material. The addition of an Engklek game is also very helpful in developing cognitive levels and activating students' motor skills. The method used in the use of Autoplay to develop learning media refers to the model developed by Lee and Owens 2004, namely the Analysis, Design, Development, Implementation and Evaluation (ADDIE) model. This development research stage is only carried out until the Analysis, Design, Development stage, because this research is only limited to developing learning media. After arriving at the development stage, the product is packaged in the form of a Compact Disk (CD) and submitted to the excretory system learning material expert and learning media expert to assess the feasibility of the product being developed, then tested on a small scale by expert practitioners and students to assess the quality of the product learning. The results of the validation of the material experts demonstrated the percentage of eligibility 95.71% with very good criteria and the results of the validation of the media experts disclosed the percentage of eligibility 97.14% with very good criteria. Supported by the results of the readability test of 10 student respondents and 1 practitioner who gave criticism and suggestions that the use of Autoplay to develop excretory system learning media with the evaluation of the designed Engklek game was very good and feasible to use.Keywords: autoplay, media development, excretory system, engklek traditional game.
PENGATURAN PRINSIP KEHATI-HATIAN PADA LEMBAGA KEUANGAN BUKAN BANK
Authors: Wibawanti Sabatika Sinung 
Published: May 2022

Sebagai sebuah industri keuangan, lembaga keuangan bukan bank juga dituntut untuk melakukan usahanya dengan memperhatikan prinsip kehati-hatian. Tetapi, tidak ada pengaturan yang secara tegas menyatakan bahwa lembaga keuangan bukan bank menganut prinsip kehati-hatian. Tidak adanya undang-undang yang secara khusus mengatur tentang lembaga keuangan bukan bank seperti layaknya UU Perbankan menjadi salah satu penyebab ketidaktegasan prinsip kehati-hatian pada lembaga keuangan bukan bank.
Unifikasi pengaturan sistem keuangan menjadi salah satu pilihan dalam mengatasi persoalan ketidaktegasan pengaturan prinsip kehati-hatian dalam lembaga keuangan bukan bank. Dalam konteks sistem hukum Indonesia, Lembaga Keuangan Bukan Bank membutuhkan pengaturannya sendiri yang tegas mengatur mengenai prinsip kehati-hatian dan terlepas dari pengaturan perbankan, tetapi masih dalam satu konstruksi harmonisasi hukum.
PENGGUNAAN NAMA DAERAH SEBAGAI TANDA PEMBEDA DALAM SUATU PRODUK
Authors: Ferdinandus Leonard Umbu Saingu 
Published: May 2022

Suatu tanda yang menjadi milik umum tidak dapat didaftarkan/digunakan sebagai merek suatu produk. Seperti yang digunakan oleh sebuah perusahaan yang menggunakan nama daerah sebagai merek produk kopi yang diberi nama “Kopi Sumba”. Dalam Pasal 20 Undang-Undang Nomor 20 Tahun 2016 tentang Merek dan Indikasi Geografis memuat unsur-unsur yang tidak dapat didaftarkan sebagai merek. Tanda milik umum tidak dapat didaftarkan sebagai merek oleh karena tanda milik umum merupakan suatu tanda yang merepresentasikan khalayak banyak dan secara otomatis tanda tersebut tidak dapat dikuasai secara individual. Tetapi tanda milik umum dapat diterima pendaftarannya melalui rezim indikasi geografis. Menurut penulis seharusnya tanda-tanda yang sudah diketahui menjadi milik umum untuk tidak dijadikan sebagai merek suatu produk oleh karena bertentangan dengan prinsip dalam hukum merek dan indikasi geografis.
A sign that has become a public property cannot be registered as a trademark. This article discusses a case in which the name of “Kopi Sumba” is used as a coffee brand product deriving the name of a region ‘Sumba’ by a company. Accordance with Article 20 of Law Number 20 of 2016 concerning Trademarks and Geographical Indications, certain categories cannot be registered as trademarks. One of them is signs of public property, which cannot be registered as trademarks because the sign of public property is a sign representing the public, so it cannot be owned by an individual. In this article, the author argues that public signs should not be used as a trademark of a product because it is against the principles in trademark law and geographical indications.