bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel nomogram based on DNA damage response-related gene expression in patients with O-6-methylguanine-DNA methyltransferase unmethylated glioblastoma receiving temozolomide chemotherapy
Authors: Wang Rong , Peng Yingpeng , Wei Wei , Zhou Yuling , Li Xiaonan , Xia Yunfei , Liu Zhigang 
Published: March 2022

Background
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and
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Aim:
Glioblastoma (GBM) is the most lethal primary brain tumor. Patients with unmethylated O-6-methylguanine-DNA methyltransferase (MGMT) promoter have higher MGMT expression, are less sensitive to temozolomide (TMZ), and are linked to poor prognosis. The aim of this study was to identify patients from this population with a better prognosis, explore the molecular mechanism, and provide a theoretical basis for the formulation of treatment strategies.

Materials
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and
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Methods:
Prognostic genes involved in the DNA damage response (DDR) pathway were screened, and the risk score of each GBM patient undergoing TMZ chemotherapy from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) database was calculated. A comprehensive prognostic nomogram model was constructed by combining the risk score and other clinical features.

Results:
Two DDR-related genes (replication factor C subunit 2 [RFC2] and methyl-CpG binding domain 4, DNA glycosylase [MBD4]) were identified as having a prognostic value in GBM patients with unmethylated MGMT promoter. Patients were classified into high- and low-risk groups using the risk score based on the expression of these two genes. The median overall survival of patients in the low-risk group was significantly longer than that recorded in the high-risk group in the TCGA cohort (15.95 vs. 11.90 months, respectively, P = 0.027) and CGGA cohort (25.90 vs. 11.87 months, respectively, P = 0.0082). The expression of those two genes was confirmed in tissue samples, and the risk scoring model showed that their prognostic value was independent of other clinical characteristics (P = 0.032), such as age. A final nomogram model was constructed, and its good performance was validated (concordance-index = 0.6656).

Conclusions:
A comprehensive prognostic model for patients with MGMT unmethylated GBM receiving TMZ chemotherapy was constructed using RFC2 and MBD4 gene expression, age, sex, and isocitrate dehydrogenase. The model showed good performance.
Positive Correlation of Oestradiol Level on Trigger Day with the Secretion Level of Endometrial Kisspeptin and Leukaemia Inhibitory Factor in the Mid-Luteal Stimulated Cycle
Authors: Polim Arie Adrianus , Abdullah Nusratuddin , Hatta Mochammad , Natzir Rosdiana , Soebijanto Soegiharto , Hutomo Caroline , Pradana Aryando , Rambei Reino 
Published: March 2022

ABSTRACT

Background:
Kisspeptin plays a role in the oestradiol negative-feedback regulation of GnRH as well as gonadotropin. In addition, kisspeptin has been postulated to induce the production of an important cytokine called leukaemia inhibitory factor (LIF).

Aims:
This study aims to investigate the correlation between varying oestradiol levels measured on trigger day of the ovarian stimulation and the mRNA expression level of endometrial kisspeptin and LIF.

Study Setting and Design:
Prospective cross-sectional study took place in Morula IVF Jakarta clinic.

Materials and Methods:
A total of 43 infertile couples underwent an in-vitro fertilization (IVF) program. Subjects were grouped based on oestradiol levels as follows: group A ([≧ 3000 pg/mL, n = 15], group B [2000–2999 pg/mL, n = 14], group C [<2000 pg/mL, n = 14]).

Statistical Analysis Used:
ANOVA test was utilised to compare the expression of kisspeptin and LIF among study groups while Pearson correlation was used to identify the correlation between variables.

Results:
A significantly higher mRNA expression of both Kisspeptin and LIF was found in group A than in groups B and C (P < 0.001). The mRNA expression of kisspeptin and LIF correlated positively with the oestradiol level (r = 0.638, P < 0.001 and r = 0.634, P < 0.001, respectively). Moreover, a strong association between Kisspeptin and LIF expression was also detected (r = 0.700, P < 0.001).

Conclusions:
mRNA expression of kisspeptin and LIF was significantly different according to the oestradiol levels in the study groups. Increased oestradiol level was shown to elevate the expression of endometrial kisspeptin and LIF in women undergoing the IVF programme.
Embryo/Fetus Doses from 18F-Fludeoxyglucose Radiopharmaceutical in Positron Emission Tomography/ Computed Tomography
Authors: Işıkçı Nazenin İpek , Demir Mustafa 
Published: March 2022

Aim:
The embryo/fetus may be accidentally exposed to ionizing radiation. The aim of this study is to calculate embryo/fetus doses in pregnant women who underwent F-18 fludeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) scan.

Materials and Methods:
Between June 2015 and June 2021, 15 pregnant women underwent F-18 FDG PET/CT applied to the Genetic Research Center (GETAM). The OLINDA/EXM package program was used for internal radiation dosimetry according to the Medical Internal Radiation Dose scheme. FetDose V4 computer software was used to compute the embryo/fetus absorbed dose from CT scan.

Results:
The amount of the injected F-18 FDG activity to patients varied between 333 and 555 MBq. The mean embryo/fetal dose from F-18 FDG was 7.2 ± 2.8 mGy. In addition, the CT component dose to the embryo/fetus dose ranged from 8.5 to 16 mGy with a mean of 12.14 ± 2.05.

Conclusions:
The embryo/fetus dose from F-18 FDG PET/CT was <15 mGy, however, questioning the women's childbearing prior to scintigraphy is the first-line strategy to avoid accidental radiation exposure and stochastic risks.
LA CONFIGURACIÓN LEGAL Y JURISPRUDENCIAL DEL DERECHO CONSTITUCIONAL A LA PROTECCIÓN DE LA SALUD
Authors: CANTERO MARTÍNEZ JOSEFA 
Published: March 2022

En este trabajo se pretende analizar la significativa evolución legal y jurisprudencial que en los últimos años se ha producido del derecho a la protección de la Salud consagrado en el artículo 43 de la Constitución. Se examina especialmente la interpretación que han venido realizando nuestros jueces y tribunales respecto de este derecho cuando ha entrado en colisión con algunos derechos fundamentales, como el derecho a la libertad religiosa, el derecho a la integridad física o el derecho a la igualdad, toda vez que estos pronunciamientos nos permiten ir delimitando el contorno, la extensión y los límites del derecho a la protección de la salud. Acontece, no obstante, que en ocasiones la interpretación realizada demuestra la existencia en nuestro ordenamiento sanitario de algunos resquicios de una concepción paternalista de la medicina, lo que no deja de ser un significativo elemento discordante en la importantísima evolución hacia la plena autonomía del paciente experimentada en los últimos años en este ámbito.
Konstituzioak 43. artikuluan aitortzen duen osasunaren babeserako eskubideak bilakaera garrantzitsua izan du azken urteetan, hala legeetan nola jurisprudentzian, eta horixe aztertzea du xede lan honek. Osasunaren babeserako eskubidea funtsezko beste eskubide batzuekin sartzen da talkan, hala nola erlijio-askatasunerako eskubidearekin, osotasun fisikorako eskubidearekin edo berdintasun-eskubidearekin, eta gure epaile eta epaitegiek horri buruz egindako interpretazioa aztertzen da bereziki. Izan ere, interpretazio hori jakinarazteko haiek egindako adierazpenetan aurkituko ditugu osasunaren babeserako eskubidearen mugak, hedadura eta soslaia zedarritzeko aukera. Hala ere, interpretazio horrek, batzuetan, erakusten du gure osasun-antolamenduan badirela medikuntzaren ikuspegi paternalista baten kutsua darien zirrikituak, eta hori ez dator bat azken urteetan eriaren autonomia osorako bidean gertatu den bilakaerarekin.
In this work we try to analyse the noteworthy legal and caselaw evolution that right to health protection established by article 43 of the Constitution has suffered during last years. It is specially studied the interpretation given by our judges and courts in relationship with this right when it collides with the right to religious freedom, with the right to physical integrity or with the right to be equally treated because all those rulings and judgments let
us mark the contours, the extension and limits of the right to health protection. It happens, however, that sometimes the given interpretation shows that in our health legal order there are some chances to a paternalist conception of medicine which is after all a clear discordant element in this very important evolution towards the full autonomy of patients as experienced in this field during last years.
LA CONTRATACIÓN DE LAS ADMINISTRACIONES PÚBLICAS Y DE LOS DEMÁS ENTES DEL SECTOR PÚBLICO. NOVEDADES. PROCEDIMIENTOS DE ADJUDICACIÓN
Authors: RAZQUIN LIZARRAGA MARTÍN MARÍA 
Published: March 2022

Este estudio trata sobre los contratos que celebran las Administraciones Públicas y demás entes del sector público, dando cuenta de las novedades introducidas al respecto por la nueva Ley de Contratos del Sector Público 30/2007, de 30 de octubre. La exposición se centra, primero, en analizar las novedades más relevantes que han significado la variación del ámbito subjetivo y de la tipología de los contratos. Después se hace especial incidencia en los procedimientos de adjudicación de los contratos públicos, resaltando las implicaciones derivadas de la aplicación de la Directiva 2004/18/CE. Para ello se explican los trámites generales del procedimiento de adjudicación así como los diferentes procedimientos a que pueden acudir los entes del sector público para la adjudicación de los contratos.
Azterlan hau herri-administrazioek eta arlo publikoko gainerako entitateek egiten dituzten kontratuei buruzkoa da, eta Arlo Publikoko Kontratuen urriaren 30eko 30/2007 Lege berriak sartu dituen berrikuntzen berri ematen du. Azalpenak, lehenik, kontratuen eremu subjektiboan eta tipologian gertatu diren berrikuntza nagusiak aztertzen ditu. Gero, kontratu publikoak esleitzeko prozedurak aztertzen dira xeheago, eta 2004/18/CE Zuzentarauaren aplikazioaren ondorioak nabarmentzen. Horretarako, esleipen-prozeduraren izapide orokorrak azaltzen dira, eta arlo publikoko erakundeek kontratuak esleitzeko zein prozeduratara jo dezaketen ere bai.
This paper studies the public procuremet of the Public Administrations and also of the rest of bodies which are inside of the public sector. It analyses the new Spanish Act (2007) about public procurement. The paper explains the new more important rules of this Act of 2007. This Act changes the public bodies or agencies subject to the Act and the new types of public contracts. Mainly, this paper studies the new procedures for the award of the public
procurement contracts. Also there are many mentions to the EU Law, especially, to the Directive 2004/18/EC. It explains the general steps of the award and also the different procedures of the public bodies for the award of their contracts.
The role of third-generation dual-source dual-energy computed tomography in characterizing the composition of renal stones with infrared spectroscopy as the reference standard
Authors: Shalini Shweta , Kasi Arunachalam Venkatesh , Kumar Varatharajaperumal Rajesh , Mehta Pankaj , S. Thambidurai , Cherian Mathew 
Published: March 2022

PurposeThe aim of our study was to prospectively evaluate the role of third-generation, dual-source, dual-energy computed tomography (DECT) in the characterization of renal calculi, with ex vivo renal stone evaluation using Fourier transform infrared spectroscopy (IS) as the reference standard.Material and methodsIn our study 50 patients with history suggestive of renal calculi were subjected to DECT using 100 kVp and Sn150 kVp. With DECT, renal stone attenuation at low and high kVp was attained, and the attenuation ratios were measured. The result of DECT was compared with IS to identify the chemical composition of the extracted renal stones. IBM SPSS version 22 was used for statistical analysis.ResultsIn our study, the mean attenuation ratio of the renal stone was 1.57 ± 0.25. Out of 50 patients, the stones of 39 patients were predicted as calcium-containing stones, in 4 patients as cystine stones, and in 7 as uric acid stones on DECT. In IS analysis, 43 patients had calcium-containing stones, and 7 patients had uric acid stones. The accuracy rate of DECT for detecting calcium and uric acid stones in our study were 90% and 100%, respectively. The positive predictive value for the DECT to assess the chemical composition of renal calculi was found to be 92%.ConclusionsThird-generation DECT scan had 100% accuracy in differentiating uric acid stones from non-uric acid stones in our study. Because the treatment is different for different chemical compositions of stones, identification of specific chemical components is very important, and it can be accurately done by DECT.
Legal Action for Climate Protection — impulses on the international level from the German Federal Constitutional Court: the Court Order from March 2021 on the Unconstitutionality of the Federal German Climate Protection Act
Authors: Tomerius Stephan 
Published: March 2022

Against the background of the international climate protection aim deriving from the “Paris Agreement” of December 2015, demanding a limitation of global warming to 1,5  Celsius at best, the public discussion and anger on the mid- and longterm consequences of a constantly growing greenhouse effect have clearly risen. Along with that, “climate litigation” has turned into serious means to sue governments for inadequate measures to reach international and domestic climate protection goals. In a line of several legal actions and high court decisions in different countries during the last years is the court order of the Federal German Constitutional Court from March 2021. The judges considered the German Federal Climate Protection Act unconstitutional due to a lack of clearing a reliable legal path to reach the CO2-reduction goals and this decision was seen as a milestone in climate litigation. Combined with the obligation of the state to protect the natural resources by legislation, the court invented the “advance interference-like effect”on future generations and the “intertemporal guarantees of freedom”, two legal figures which could be possibly applied to constitutional law abroad and thus fertilize argumentation in climate litigation outside of Germany, too.
Impacto de la economía del conocimiento en la Universidad Pública
Authors: Aboslaiman Lucrecia 
Published: March 2022

Mediante este trabajo se propone reflexionar acerca de la incidencia de la economía del conocimiento en la Universidad Pública y cómo impacta en la función de extensión, esta última entendida como construcción de diferentes sistemas de acciones dirigidas a promover y potenciar el vínculo universidad‐sociedad, desde la integración de las funciones universitarias, las disciplinas y saberes. Esto implica un cuestionamiento a lo instituido, permitiendo cambios culturales profundos, la reconstrucción del conocimiento académico, el abordaje interdisciplinario, compromiso ético, social, político y la innovación.
La metodología utilizada es descriptiva con base en textos pertinentes, desde la búsqueda de bibliografía y fuentes adecuadas. Se tiene como conclusión que la política extensionista que forma parte de la política educacional, debe tener como objetivo el fundamento que la sociedad demanda en la construcción de saberes y en la extensión de los mismos a una sociedad compleja y globalizada.
Dampak Penggunaan Gadget pada Interaksi Sosial Anak Usia Dini
Authors: Nur Mutmainnatul Itsna  , Risatur Rofi’ah  
Published: March 2022

Gadget is an electronic device that has a special function on each device. It is important to understand the influence of gadgets, especially for parents, so that parents can limit their children's use of gadgets so that children's developmental abilities develop well and become active, intelligent, and interactive children with others. Excessive use of gadgets will be able to affect the lack of social interaction in children in the environment. Based on the description above, the formulation of the problem in this study can be determined, namely (1) How is the impact of gadget use on early childhood social interaction in Sendangagung Paciran Lamongan Village (2) What are the factors that influence the use of gadgets in early childhood. The purpose of this study is to find out how the impact of using gadgets on early childhood social interactions in Sendangagung Paciran Lamongan Village and to find out what are the factors that influence the use of gadgets in early childhood. In this study, researchers used descriptive qualitative research methods. Data collection procedures are interviews, observation and documentation. Checking the validity of the data carried out is triangulation. The results of this study indicate that the use of gadgets in early childhood has positive and negative impacts. The positive impact is making it easier for a child to obtain information and making children more creative through the available features, while the negative impacts include lack of interaction, decreased social skills, dependence. by gadgets. From these results, it is suggested that future researchers can develop other variables so that they will enrich scientific findings in the impact of gadget use on early childhood.
ANALISIS DAMPAK LALU LINTAS PEMBANGUNAN GEDUNG PLN (PERSERO) TANAH WAHIDIN (Studi Kasus : Kantor PLN Jl. Dr. Wahidin Sudirohusodo, Kel. Macannang, Kec. Tanete Riattang, Kab. Bone)
Authors: Andriyani Andriyani , Azikin M. Thahir 
Published: March 2022

ABSTRAKPembangunan suatu kawasan dan/atau lokasi tertentu mempunyai pengaruh terhadap lalu lintas disekitarnya. Analisis dampak lalu lintas dipergunakan untuk memprediksi apakah infrastruktur transportasi dalam daerah pengaruh pembangunan tersebut dapat melayani lalu lintas yang ada (eksisting) ditambah dengan lalu lintas yang dibangkitkan atau ditarik oleh pembangunan tersebut. Jika prasarana yang ada tidak dapat mendukung lalu lintas tersebut maka harus dilakukan kajian penanganan prasarana tersebut atau pengaturan manajemen terhadap lalu lintasnya.Analisis Dampak Lalu lintas (Andalalin) pada dasarnya merupakan analisis pengaruh pengembangan tata guna lahan terhadap sistem pergerakan arus lalu lintas disekitarnya, yang diakibatkan oleh bangkitan lalu lintas yang baru, lalu lintas yang beralih dan oleh kendaraan keluar masuk dari/ke lahan tersebut. Andalalin sangat beragam, bergantung pada kondisi setempat dan kebijakan yang ada. Andalalin dapat bersifat makroskopik pada tahap pra-kajian kelayakan suatu pengembangan lahan, yang perhatian utamanya lebih diarahkan pada sistem transportasi makronya, selain itu dapat juga bersifat rinci (mikroskopik). Kebijakan pengendalian dampak lalu lintas dapat berupa usaha meminimalkan dampak lalu lintas, misalnya peningkatan kapasitas jalan.Secara umum telah diterima suatu konsep analisis “menginternalkan eksternalitis” dengan konsekuensi “poluter pays” dengan pengertian bahwa pihak pengembang harus memberikan kontribusi yang nyata dalam penanganan dampak lalu lintas sebagai akibat pengembangan suatu kawasan atau lokasi tertentu. Bangunan PT. PLN (Persero) Tanah Wahidin akan merubah pergerakan perjalanan yang ada dan membawa dampak permasalahan lalu lintas di daerah sekitarnya. Oleh karena itu, diperlukan kajian manajemen dan rekayasa lalu lintas untuk meminimumkan dampak tersebut. Kata Kunci : Andalalin, Penanganan Dampak Lalu Lintas, Kajian Manajemen dan Rekayasa Lalu Lintas
ANALISIS PEMAKAIAN DERMAGA TERHADAP LAYANAN KAPAL PADA PELABUHAN PAJALA KABUPATEN MUNA BARAT
Authors: Putri Tryantini Sundi , Welendo La , Rustan Fathur Rahman , Latimba Yusran 
Published: March 2022

ABSTRAKPelabuhan Pajala adalah salah satu pelabuhan yang berada di wilayah Kabupaten Muna Barat Provinsi Sulawesi Tenggara, sebagai urat nadi perekonomian Kabupaten Muna Barat khususnya arus keluar masuk barang dan penumpang melalui angkutan laut. Tujuan Penelitian ini adalah menganalisis nilai BOR dan menganalisis panjang dermaga (Lp) pada Deramaga Pelabuhan Pajala Kabupaten Muna Barat. Penelitian ini merupakan studi kasus dengan menggunakan metode pengamatan langsung dengan wawancara kepada pihak pengelola pelabuhan. Hasil analisis tingkat pemakaian dermaga terhadap waktu kunjungan kapal, untuk naik/turun penumpang dan bongkar/muat barang pada Pelabuhan Pajala mencapai 96,5% > 50% nilai BOR yang di standarkan oleh UNCTAD untuk dermaga dengan 2 tambatan. Jadi, pelabuhan Pajala saat ini belum mampu melayani arus kapal dengan baik atau pemakaian dermaga belum efektif dan hasil analisis kebutuhan layanan kapal terhadap ukuran dermaga pada Pelabuhan Pajala untuk menghitung gabungan ukuran kapal terbesar untuk melakukan sandar 2 kapal sekaligus tidak bisa dilayani karena ukuran dermaga yang dibutukan 46 m > 5 m ukuran dermaga yang ada saat ini dan untuk ukuran kapal terkecil untuk melakukan sandar 2 kapal sekaligus tidak bisa dilayani karena ukuran dermaga yang dibutukan 45,2 m > 47 m ukuran dermaga yang ada di Pelabuhan Pajala. Kata Kunci : BOR, Kinerja, DermagaABSTRACTPajala port is a port that is located in the district of West Muna Sulawesi Tenggara as the economic lifeblood West Muna. Especially the flow of goods and passengers by sea freight. The purpose of this study is to analyze the value of BOR and analyze the value of Lp in Pajala port West Muna. This research is a case study using the method of direct observation by interviewing the manager of the port. Results of the analysis of the consumption levels of the dock to the time the ship visits for up / down passengers and loading / unloading of goods at the port of Pajala 96,5%> 50% in value BOR standardize by UNCTAD to dock with 2 moorings. So port Pajala is not currently able to serve the flow of ships with either or usage dock has not been effective, and the results of a needs analysis service of the vessel to the size of the dock at the port of Pajala for sampling the combined size of the largest ships to berth two ships at the same time can not be served because of the size of the dock needed 46 m> 5 m size of the existing quay at the moment and for the size of the vessel smallest to berth two ships at the same time can not be served because the size dock needed 45,2 m> 5 m size of the existing quay in the port of Pajala. Keywords : BOR, Performance, Pier