bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insight into the selective oxidation mechanism of glycerol to 1,3‐dihydroxyacetoneoverAuCu–ZnOinterface
Authors: Zhao Mingyue , Yan Hao , Lu Ruilong , Liu Yibin , Zhou Xin , Chen Xiaobo , Feng Xiang , Duan Hongchang , Yang Chaohe 
Published: July 2022

AbstractDirectional regulation of polyol oxidation selectivity by constructing active sites with specific structure is a critical yet challenging problem. Herein, the specific Au‐based catalyst with efficient Au–Cu–ZnO interfacial active sites was successfully designed to promote selective oxidation of glycerol to 1,3‐dihydroxyacetone under mild conditions. X‐ray absorption spectroscopy revealed that the increased electron transfer between Au and Cu increases the content of Au+, resulting in the higher catalytic activity (turnover frequency: 402.5 h−1). Meanwhile, small AuCu alloy nanoparticles (ca., 2.7 nm) could be inserted into the ZnO lattice with the formation of Au(Cu)–O–Zn linkages, resulting in the enrichment of interfacial oxygen vacancies. These interfacial oxygen vacancies induce the activation and adsorption of the secondary hydroxyl group of glycerol on the interfacial active sites, improving the selectivity of 1,3‐dihydroxyacetone (83.4%). Furthermore,in situFourier transform infrared, structure‐dependent kinetics and density functional theory calculation demonstrated that Au–Cu–ZnO interfacial active sites could enhance the participation of OH* and oxygen vacancies in activating the OH and CH bonds, respectively, promoting the improvement of the catalytic performance. The outcome of this work offers new insights for the rational design of high effective catalyst for the selective oxidation of polyol.
Porous washcoat structure in CeO2 modified Cu‐SSZ‐13 monolith catalyst for NH3‐SCR with improved catalytic performance
Authors: Liu Wuyuan , Wang Zhaoying , Sun Ming , Gao Jiajian , Wang Lifeng , Gao Zihan , Xu Yingying , Zhao Xiangyun , Zhang Cheng , Yu Lin 
Published: July 2022

AbstractA series of CeO2 modified Cu‐SSZ‐13 monolith catalysts were prepared by embedding CeO2 into the washcoat of Cu‐SSZ‐13 monolith catalyst through solvent combustion method. These CexCu‐SSZ‐13 catalysts were studied in the selective catalytic reduction (SCR) of NO with NH3, among which the Ce2Cu‐SSZ‐13 catalyst exhibited the best low‐temperature activity, hydrothermal stability, and sulfur resistance. The physicochemical properties of the catalysts were characterized using multiple methods. Results showed that the acidity, redox capacity, and ammonia adsorption capacity significantly enhanced after CeO2 modification, thus leading to the high performance of Ce2Cu‐SSZ‐13 catalyst. Furthermore, the introduction of CeO2 induced the fast SCR reaction by promoting the oxidation of NO to NO2. Analog calculation suggested that the porous structure generated via solvent combustion in the washcoat effectively increased the diffusion rate of reaction. In situ diffuse reflectance infrared Fourier transform spectroscopy (in situ DRIFT) analysis showed that Brønsted acid sites were the main active center and the reaction followed Eley–Rideal mechanism.
Catalytic Enantioselectivede novoConstruction of Chiral Arenes through Desymmetrizing Oxidative [4+2]‐Cycloaddition
Authors: Ghosh Biki , Harariya Mahesh Singh , Mukherjee Santanu 
Published: July 2022

AbstractCentral chirality in arene derivatives arising out of unsymmetrically substituted arene ring is a fascinating yet rarely explored research topic. Here, we report a desymmetrization approach to centrally chiral unfunctionalized arenes, which is enabled by the enantioselectivede novoconstruction of the arene ring. This operationally simple protocol is based on a [4+2]‐cycloaddition between polycyclicmeso‐cyclohexenediones and α,β‐unsaturated aldehydes, and doesn't usually require any external oxidant. Catalyzed by a diphenylprolinol silyl ether, this reaction proceeds via dienamine intermediate and greatly simplifies the access to diversely substituted chiral arenes with outstanding enantioselectivities.
Differential Dihydrofunctionalization: A Dual Catalytic Three‐Component Coupling of Alkynes, Alkenyl Bromides, and Pinacolborane
Authors: Baumann James E. , Lalic Gojko 
Published: July 2022

AbstractA new method for differential dihydrofunctionalization of terminal alkynes enables the synthesis of allylic boronate esters through reductive three‐component coupling of terminal alkynes, alkenyl bromides, and pinacolborane. The transformation is promoted by cooperative action of a copper/palladium catalyst system and results in hydrofunctionalization of both π‐bonds of an alkyne. The synthesis of allylic boronate esters can be accomplished in the presence of a wide range of functional groups, including, esters, nitriles, alkyl halides, sulfonyl esters, acetals, protected terminal alkynes, aryl halides, and silyl ethers. Mechanistic experiments reveal the importance of subtle ligand effects on the performance of the palladium co‐catalyst.
Engineering Bio‐inspired Self‐assembled Nanochannels for Smart Ion Transport
Authors: Xin Weiwen , Jiang Lei , Wen Liping 
Published: July 2022

AbstractHighly efficient biological ion channels with sophisticated transport characteristics in living organisms have inspired the design of artificial channels that are functionally comparable to those of their natural counterparts and applicable on a much larger scale. Self‐assembly currently offers a facile approach for producing nanoconfined ion channels that exhibit smart ion‐transport properties, including ion selectivity, gating, and rectification, and have shown great potential for various applications. In this Minireview, we give an overview of strategies for engineering bio‐inspired self‐assembled ion channels. We focus on emerging channel assemblies based on different fabrication processes such as supramolecular assembly, nanosystem‐based fabrication, and polymer‐based integration. The applications of these bio‐inspired channels in the exploration of physiological events, detection of molecules/ions, ion separation, and energy conversion are concisely presented. Finally, future developments and challenges of this booming research field are proposed.
Antineoplastic Enzyme as Drug Carrier with Activatable Catalytic Activity for Efficient Combined Therapy
Authors: Zhang Yifan , Jiang Shanshan , Lin Jing , Huang Peng 
Published: July 2022

AbstractThe delivery of glucose oxidase (GOx) requires extra carriers, which suffers from early leakage and exposure of GOx. These issues will be of less concern if GOx itself acts as a drug carrier. However, the catalytic activity of GOx in the blood still needs to be inhibited. Herein, we found that GOx could self‐assemble with hydrophobic molecules into uniform and stable nanoparticles (NPs), including sorafenib, 4′‐(amino‐methyl phenyl)‐2,2′ : 6′,2′′‐terpyridine modified cyanin and paclitaxel. The catalytic activity of GOx in NPs was significantly inhibited due to the binding of small molecules with its hydrophobic pockets. After dissociation in the tumor acidic microenvironment, the enzyme activity of GOx could be largely recovered. This acidity‐triggered “OFF‐to‐ON” process ensured safe intravenous administration of GOx‐based NPs. In vivo experiments showed that the combined starvation therapy and ferroptosis/photothermal therapy/chemotherapy effectively inhibited 4T1 breast tumor growth.
Vier Bauingenieure der Berliner Bauakademie
Authors: Kurrer Karl‐Eugen 
Published: July 2022

AbstractIn der Öffentlichkeit ist die 1799 gegründete und mit der Gewerbeakademie 1879 zur TH Berlin‐Charlottenburg (heute: TU Berlin) vereinigte Berliner Bauakademie als Lehrstätte für Architekten bekannt. Das liegt nicht zuletzt darin begründet, dass sie mit Karl Friedrich Schinkel (1781–1841) verbunden wird, der den Klassizismus Preußens prägte und mit seinem 1836 fertiggestellten Akademiegebäude eines ihrer Leitbauwerke schuf. Gleichwohl wohnte der Bauakademie eine unentdeckte Dimension inne, die als Genius Loci der sich verwissenschaftlichenden Bauingenieurkunst des 19. Jahrhunderts bezeichnet werden kann. Am Beispiel der Bauakademiker Johann Albert Eytelwein (1764–1849), Gotthilf Hagen (1797–1884), Johann Wilhelm Schwedler (1823–1894) und James Hobrecht (1825–1902) soll dieser folgenreiche Prozess der Trennung der Baukunst in Architektur und Bauingenieurwissenschaften konkretisiert und darüber hinaus die enge Verbundenheit mit dem Verlag Ernst & Korn (heute: Ernst & Sohn) aufgezeigt werden.
Chemical Substitution‐Grown Lithium‐Magnesium Alloy as Ion Redistributor and Surface Protector for Highly Stable Lithium‐Metal Anode
Authors: Zhao Zenan , Qian Mengmeng , Wang Jing , Cao Wenze , Qin Xianfu , Guo Penghui , Hao Shuang , Wang Ran , Wu Feng , Tan Guoqiang 
Published: July 2022

AbstractAddressing lithium‐dendrite problem caused by uneven lithium (Li) plating/stripping is crucial for improving cycle‐life and safety of Li‐metal batteries. Here we describe a simple chemical substitution method of 2Li+Mg(PF6)2=Mg+2LiPF6 to construct a highly stable Li−Mg alloy on Li metal anode. The self‐grown Li−Mg alloy exhibits homogeneous β‐phase bulk structure with flat and dense surface morphology. Systematic studies reveal that the obtained Li−Mg film acts as ion redistributor and surface stabilizer to protect Li metal anode by its low strain, fast conductivity, superior lithophilicity and excellent stability. Compared to the bare Li metal, symmetric cells assembled using Li−Mg‐protected Li exhibit better cycling performance with lower charge‐discharge overpotential. Notably, this Li−Mg film demonstrates great potential for Li‐metal batteries, it can effectively suppress Li‐dendrite growth and work effectively in LiFePO4//Li and LiNi0.8Co0.1Mn0.1O2//Li cells. This work provides a simple and effective strategy to construct Li‐ion redistributor and surface protector to guard Li anodes operating in high‐energy Li batteries.
Cell metabolomics study on synergistic anti‐hepatocellular carcinoma effect of Aidi injection combined with doxorubicin
Authors: Wang Yanli , Zhu Xiaoqing , Wang Kailiang , Cai Ying , Liu Chunhua , Pan Jie , Sun Jia , Liu Ting , Huang Yong , Li Yongjun , Lu Yuan 
Published: July 2022

AbstractHepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the second most common cause of cancer deaths. This study aimed to explore the inhibitory effect and mechanism of Aidi injection (ADI) combined with doxorubicin (DOX) in HCC treatment. The drug concentrations in the combined therapy was determined by investigating the effect of various concentrations of ADI and DOX on the viability of H22 cells. The combination index was also calculated. A metabolomic strategy based on a ultrahigh‐performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) platform was established to analyze the metabolites. As a result, the combination index values were less than 1, indicating that the combination of ADI and DOX exerted a synergistic effect on HCC treatment. The combination of 40‰ ADI and 1 μmol/l DOX had the strongest inhibitory effect and was used for subsequent metabolomic analysis. A total of 19 metabolic markers were obtained in metabolomic analysis, including amino acids (l‐glutamic acid, l‐arginine and l‐tyrosine), organic acids (succinic acid and citric acid), adenosine and hypoxanthine. Compared with the treatment using DOX or ADI alone, the combined therapy further regulated the levels of metabolic markers in HCC, which may be the reason for the synergistic effect. Seven metabolic pathways were significantly enriched, including phenylalanine, tyrosine and tryptophan biosynthesis, d‐glutamine and d‐glutamate metabolism, alanine, aspartate and glutamate metabolism, phenylalanine metabolism, arginine biosynthesis, the tricarboxylic acid cycle and purine metabolism. These findings demonstrated that ADI combined with DOX can effectively inhibit the viability of H22 cells, which may exert a synergistic antitumor effect by balancing the metabolism of amino acids and energy‐related substances.
Quantitative changes in mental health measures with 3MDR treatment for Canadian military members and veterans
Authors: Jones Chelsea , Smith‐MacDonald Lorraine , Brown Matthew Robert Graham , Pike Ashley , Vermetten Eric , Brémault‐Phillips Suzette 
Published: July 2022

AbstractObjectiveMilitary members and veterans are at elevated risk of treatment‐resistant posttraumatic stress disorder (TR‐PTSD) due to higher rates of exposure to potentially traumatic events during the course of duty. Knowledge of TR‐PTSD is limited, and specific protocols or evidence‐based TR‐PTSD therapies are lacking. Multimodal motion‐assisted memory desensitization and reconsolidation (3MDR) therapy is an emerging intervention for combat‐related TR‐PTSD. The purpose of this study was to preliminarily assess the effectiveness of 3MDR in addressing TR‐PTSD in Canadian military members and veterans.MethodsThis study is a longitudinal mixed‐methods clinical trial. English‐speaking military members and veterans aged 18–60 with TR‐PTSD were recruited to participate. The intervention consisted of six sessions of 3MDR therapy. Quantitative data were collected pretreatment, posttreatment, and longitudinally at 1, 3, and 6 months after completion of 3MDR.ResultsResults from the first 11 participants to complete the 3MDR protocol exhibited statistically significant improvement (surviving multiple comparison correction) in clinically administered and self‐reported scores for PTSD (CAPS‐5 and PCL‐5), moral injury (MISS‐M‐SF), depression (PHQ‐9), anxiety (GAD‐7), emotional regulation (DERS‐18), and resilience (CD‐RS‐25).ConclusionThe preliminary and exploratory results from this clinical trial support the growing body of literature illustrating 3MDR as an effective treatment for military‐related TR‐PTSD. These results are notable given participants' previous lack of success with frontline psychotherapeutic and pharmacological interventions. Given that there are currently very limited treatment options for TR‐PTSD, 3MDR could prove to be a valuable treatment option for military members and veterans with TR‐PTSD.
Ginsenoside Rh2 administration produces crucial antidepressant‐like effects in a CUMS‐induced mice model of depression
Authors: Shi Lin‐Sheng , Ji Chun‐Hui , Liu Yue , Gu Jiang‐Hong , Tang Wen‐Qian , Zhang Wei , Guan Wei 
Published: July 2022

AbstractIntroductionThe most striking feature of depression is sadness and a loss of interest in activities, which represents a major cause of disability globally. Therefore, it is necessary to identify novel antidepressants for clinical practice. Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides that can be extracted from Panax ginseng and has been demonstrated to improve both memory and learning. The purpose of this study was to provide broad insight into the mechanisms underlying depression and gain greater insights into antidepressant therapy.MethodsIn this study, we first established an effective and feasible depression animal model of chronic unpredictable mild stress (CUMS) and behavioral testing was evaluated by the forced swim test (FST), the tail suspension test (TST) and the sucrose preference test. Following pretreatment with Rh2 (10 and 20 mg/kg), the immobility time of mice was reduced without affecting locomotor activity in both the FST and TST. Western blotting and immunofluorescence were used to investigate the activation of the hippocampal BDNF signaling pathway and hippocampal neurogenesis.ResultsDifferent concentrations of Rh2 significantly reduced depressive‐like symptoms in CUMS‐induced mice and downregulated the effects of the BDNF signaling cascade and neurogenesis in the hippocampus. Furthermore, the administration of K252a completely prevented the antidepressant‐like activity of Rh2 in mice.ConclusionThe results indicated that Rh2 possesses the antidepression action via the positive regulation of the BDNF‐TrkB pathway.
Distinct response properties between the FFA to faces and the PPA to houses
Authors: Li Mengjin , Huang Hong , Guo Bingbing , Meng Ming 
Published: July 2022

AbstractIntroductionThe object recognition system involves both selectivity to specific object category and invariance to changes in low‐level visual features. Mounting neuroimaging evidence supports that brain areas in the ventral temporal cortex, such as the FFA and PPA, respond preferentially to faces and houses, respectively. However, how regions in human ventral temporal cortex partitioned and functionally organized to selectively and invariantly respond to different object categories remains unclear. What are the changes of response properties at the intersection of adjacent but distinctively‐selective regions?MethodHere, we conducted an fMRI study and three‐pronged analyses to compare the brain mapping relationships between the FFA to faces and the PPA to houses. Specifically, we examined: 1) the response properties of object selectivity to the preferred category; 2) the response properties of invariance to contrast and a concurrently presented non‐preferred category; 3) whether there are asymmetrical changes of response properties across the boundary from the FFA to PPA versus from the PPA to FFA.ResultsWe found that the response properties of FFA are highly selective and reliably invariant, whereas the responses of PPA vary with the image contrast and concurrently presented face. Moreover, the response properties across the boundary between the FFA and PPA are asymmetrical from face‐selective to house‐selective relative to from house‐selective to face‐selective.ConclusionsThese results convergently revealed distinct response properties between the FFA to faces and the PPA to houses, implying a combination of spatially discrete domain‐specific and relatively distributed domain‐general organization mapping in human ventral temporal cortex.
The E3 ubiquitin ligase HUWE1 acts through the N‐Myc‐DLL1‐NOTCH1 signaling axis to suppress glioblastoma progression
Authors: Yuan Ye , Wang Li‐Hong , Zhao Xian‐Xian , Wang Jiao , Zhang Meng‐Si , Ma Qing‐Hua , Wei Sen , Yan Ze‐Xuan , Cheng Yue , Chen Xiao‐Qing , Zou Hong‐Bo , Ge Jia , Wang Yan , Zhang Xia , Cui You‐Hong , Luo Tao , Bian Xiu‐Wu 
Published: July 2022

AbstractBackgroundElucidation of the post‐transcriptional modification has led to novel strategies to treat intractable tumors, especially glioblastoma (GBM). The ubiquitin‐proteasome system (UPS) mediates a reversible, stringent and stepwise post‐translational modification which is closely associated with malignant processes of GBM. To this end, developing novel therapeutic approaches to target the UPS may contribute to the treatment of this disease. This study aimed to screen the vital and aberrantly regulated component of the UPS in GBM. Based on the molecular identification, functional characterization, and mechanism investigation, we sought to elaborate a novel therapeutic strategy to target this vital factor to combat GBM.MethodsWe combined glioma datasets and human patient samples to screen and identify aberrantly regulated E3 ubiquitin ligase. Multidimensional database analysis and molecular and functional experiments in vivo and in vitro were used to evaluate the roles of HECT, UBA and WWE domain‐containing E3 ubiquitin ligase 1 (HUWE1) in GBM. dCas9 synergistic activation mediator system and recombinant adeno‐associated virus (rAAV) were used to endogenously overexpress full‐length HUWE1 in vitro and in glioma orthotopic xenografts.ResultsLow expression of HUWE1 was closely associated with worse prognosis of GBM patients. The ubiquitination and subsequent degradation of N‐Myc mediated by HUWE1, leading to the inactivation of downstream Delta‐like 1 (DLL1)‐NOTCH1 signaling pathways, inhibited the proliferation, invasion, and migration of GBM cells in vitro and in vivo. A rAAV dual‐vector system for packaging and delivery of dCas9‐VP64 was used to augment endogenous HUWE1 expression in vivo and showed an antitumor activity in glioma orthotopic xenografts.ConclusionsThe E3 ubiquitin ligase HUWE1 acts through the N‐Myc‐DLL1‐NOTCH1 signaling axis to suppress GBM progression. Antitumor activity of rAAV dual‐vector delivering dCas9‐HUWE1 system uncovers a promising therapeutic strategy for GBM.
“Pulling back the curtain”: Company tours as a customer education tool and effects on pro‐brand behaviors
Authors: Sun Xiaochi , Foscht Thomas , Kerschbaumer René Hubert , Eisingerich Andreas B. 
Published: July 2022

AbstractIn numerous countries around the world, it is popular for companies to offer company tours as part of their marketing communication strategies. Extant research has investigated such tours in business‐to‐business settings or considered them a kind of tourism. To date, limited empirical evidence has shed light on whether and how company tours, as a novel customer education tool, influence individual customers' pro‐brand behaviors. With two field experiments, one covering the service context and the other involving consumer goods, we found that a company tour is able to quickly enhance customers' positive word‐of‐mouth (WOM) and purchase intentions for a brand. Critically, the mechanism for such effects is that a company tour shapes customers' cognitive and affective processes by enhancing their knowledge and enjoyment levels. Furthermore, we demonstrate that the positive effects on customer pro‐brand behaviors can be amplified for customers with a lower level of brand familiarity. This study theorizes and empirically demonstrates how brands can better leverage the power of company tours to educate and affect individual customers in brand‐marketing communications.
Unprecedented 4,9‐Seco‐Oplopanane and Seven Drimane Sesquiterpenoids from the Chinese Liverwort Lejeunea flava (Sw.) Nees
Authors: Zhu Ming‐Zhu , Li Yi , Zhou Jin‐Chuan , Wang Tian , Qian Li‐Lin , Zhang Jiao‐Zhen , Han Jing‐Jing , Xu Ze‐Jun , Shen Tao , Lou Hong‐Xiang 
Published: July 2022

AbstractAn unprecedented 4,9‐seco‐oplopanane (1), two undescribed drimane epimers (2 and 3), and five known drimane sesquiterpenoids (4–8) were isolated from the Chinese liverwort Lejeunea flava (Sw.) Nees. The structures of the new sesquiterpenoids were determined using nuclear magnetic resonance spectroscopy, electronic circular dichroism calculations, and single‐crystal X‐ray diffraction measurements. The inhibitory capacity of the new compounds against nitric oxide production in lipopolysaccharide‐induced RAW 264.7 murine macrophages, along with the cytotoxicity of the new compounds against A549 and HepG‐2 human cancer cell lines, were discussed.
Correlating Structures to Electrochemiluminescence Efficiencies of Silole Compounds in Coreactant Systems
Authors: Qin Xiaoli , Yang Liuqing , Wang Xin , Patel Darshil , Chu Kenneth , Kelland Lindsay , Adsetts Jonathan Ralph , Zhang Congyang , Workentin Mark Steven , Pagenkopf Brian L. , Ding Zhifeng 
Published: July 2022

AbstractTo develop efficient electrochemiluminescence (ECL) of activated silole chromophores, the relative ECL efficiencies of eight thiophene‐containing compounds are firstly studied in a coreactant pathway. The experimental results show that the extended π‐conjugated systems and donor groups of the silole emitters affect both the radical stability and emission efficiencies. It is found that the 1,1‐di‐tert‐butyl‐2,5‐bis[(2,2′‐bithiophen)‐5‐yl]‐3,4‐diphenylsilole (2c) compound with benzoyl peroxide (BPO) as a coreactant exhibits the highest relative ECL efficiencies among the studied systems due to its structural properties. Moreover, the absolute ECL efficiency of the potential pulsing/ECL experiment in the coreactant pathway is 6‐fold larger than that in the potentiodynamic experiment due to the short time interval for the radical species to meet and react. This work provides a guidance for structural modification of silole compounds to tune ECL performance.