bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rethinking the university: a case study
Authors: Davis Alan R. , Jhangiani Rajiv , Purvey Diane 
Published: December 2022

Purpose
This study aims to describe and illuminate the ways in which Kwantlen Polytechnic University (KPU) – an urban, undergraduate institution with a strong focus on teaching, learning and related research and scholarship, and a substantial international student population – adapted to pandemic conditions in 2020 in an effort to meet community and pedagogical priorities, institutional/legal responsibilities and strategic goals.

Design/methodology/approach
Three institutional leaders at KPU draw together their respective insights and experiences, reflecting on how governance, pedagogy and operations were impacted by COVID-19.

Findings
After two years of continuous operation during the COVID-19 pandemic, and with the strong support of its learners and the faculty, KPU has undergone significant pedagogical and technological shifts to become a multi-modal university for study, teaching and administration.

Research limitations/implications
This is a “practitioner paper” with a practical focus on institutional leadership and adaptation in a period of rapid adjustment. It is more of an accounting and reflection piece than a critical analysis.

Practical implications
It offers post-secondary leaders’ insights into ways in which institutional values and community needs inform policy-making, operations and innovation in education.

Social implications
KPU’s domestic and international student constituencies are complex and required unconventional post-secondary strategies regarding faculty autonomy and growth, de-colonization and inclusion.

Originality/value
KPU has a distinctive mandate in British Columbia and its commitment to experiential learning – typically associated with hands-on education – presented unusual challenges for delivery. While research-and-teaching universities were tested by COVID-19, their tests were largely alike. KPU’s experience illustrates what practical- and teaching-focused institutions confronted.
LINC02323 facilitates development of lung squamous cell carcinoma by miRNA sponge and RBP dysregulation and links to poor prognosis
Authors: Wu Kuan‐Li , Tsai Ying‐Ming , Huang Yung‐Chi , Wu Yu‐Yuan , Chang Chao‐Yuan , Liu Yu‐Wei , Hsu Ya‐Ling , Hung Jen‐Yu 
Published: December 2022

AbstractBackgroundThe poor outcome of patients with lung squamous cell carcinoma (LUSC) highlights the importance of the identification of novel effective prognostic markers and therapeutic targets. Long noncoding RNAs (lncRNAs) have generally been considered to serve important roles in tumorigenesis and the development of various types of cancer, including LUSC.MethodsHere, we aimed to investigate the role of LINC02323 in LUSC and its potential mechanisms by performing comprehensive bioinformatic analyses.ResultsLINC02323 was elevated and positively associated with unfavorable prognosis of LUSC patients. LINC02323 exerted oncogenic function by competitively binding to miR‐1343‐3p and miR‐6783‐3p, thereby upregulating L1CAM expression. Indeed, we also determined that LINC02323 could interact with the RNA‐binding protein DDX3X, which regulates various stages of RNA expression and processing.ConclusionTaken together, we identified that LINC02323 and its indirect target L1CAM can act as novel biomarkers for determining the prognosis of patients with LUSC and thus deserves further study.
Non‐small cell lung cancer with EGFR (L858R and E709X) and CNNB1 mutations responded to afatinib
Authors: Kunishige Michihiro , Ichihara Seiya , Kadota Naoki , Okano Yoshio , Machida Hisanori , Hatakeyama Nobuo , Naruse Keishi , Shinohara Tsutomu , Takeuchi Eiji 
Published: December 2022

AbstractLung cancer with complex epidermal growth factor receptor (EGFR) and CTNNB1 comutations is rare, and the efficacy of tyrosine kinase inhibitors (TKIs) is generally poor. Here, we encountered a lung cancer patient with complex EGFR (L858R and E709X) and CTNNB1 comutations who successfully responded to afatinib. A 78‐year‐old woman visited our hospital with a cough and bloody sputum that had worsened over the past year. She had multiple mass shadows in both lungs and nodular shadows in the bronchi. The patient was diagnosed with lung adenocarcinoma cT4N3M1c stage IVB. A genetic analysis of the primary tumor using the Oncomine Dx target test multi‐CDx system revealed positivity for EGFR (L858R and E709X) and CTNNB1 mutations. The expression of programmed death ligand 1 (22C3 clones) in tumor cells was negative by immunostaining. The patient was treated with afatinib as first‐line therapy and achieved clinical improvement and a partial response and is continuing treatment 1 year later. Case reports of lung cancer patients with EGFR/CTNNB1 comutations are rare, and TKIs are not considered to be effective. We herein present the first case report of lung cancer with the co‐occurrence of uncommon and complex EGFR (L858R and E709X) and CTNNB1 mutations that was successfully treated with afatinib.
Immunovascular microenvironment in relation to prognostic heterogeneity of WNT/β‐catenin‐activated hepatocellular carcinoma
Authors: Matsuda Kosuke , Kurebayashi Yutaka , Masugi Yohei , Yamazaki Ken , Ueno Akihisa , Tsujikawa Hanako , Ojima Hidenori , Kitago Minoru , Itano Osamu , Shinoda Masahiro , Abe Yuta , Sakamoto Michiie 
Published: December 2022

AbstractAimWNT/β‐catenin‐activated hepatocellular carcinoma (W/B subclass HCC) is considered a molecularly homogeneous entity and has been linked to resistance to immunotherapy. However, recent studies have indicated possible heterogeneity in the immunovascular microenvironment in this subclass. We set out to test the hypothesis that specific immunovascular features might stratify W/B subclass HCCs into tumors having distinct aggressive natures.MethodsIn this study, we analyzed 352 resected HCCs including 78 immunohistochemically defined W/B subclass HCCs. The density of tumor‐infiltrating CD3+ T cells and the area ratio of vessels encapsulating tumor clusters (VETC) were calculated on tissue specimens. The gene expressions of angiogenic factors were measured by quantitative reverse transcription–polymerase chain reaction. Disease‐free survival (DFS) was assessed using multivariable Cox regression analyses.ResultsThe T‐cell density of W/B subclass HCCs was regionally heterogenous within tumor tissues, and focally reduced T‐cell density was observed in areas with VETC. VETC‐positivity (defined as VETC area ratio greater than 1%) was inversely associated with T‐cell infiltration in both W/B subclass and non‐W/B subclass HCCs. Fibroblast growth factor 2 (FGF2) gene expression was higher in W/B subclass than in non‐W/B subclass HCCs. The VETC‐positivity and low T‐cell density correlated with increased expression of FGF2 in W/B subclass HCCs. Additionally, VETC‐positive HCCs showed significantly shorter DFS in W/B subclass HCCs.ConclusionsIn conclusion, the immune and vascular microenvironments are interrelated and are also correlated with clinicopathological heterogeneity in W/B subclass HCC. These results could inform clinical practice and translational research on the development of therapeutic stratification of HCCs.
Treatments of orange‐spotted grouper (Epinephelus coioides) against Cryptocaryon irritans with •OH, ClO2 or HCHO: Survival, physiological and histological response
Authors: Zhong Ziqing , Wu Xiping , Bai Mindong , Huang Xiaodian , Zheng Qilin , Ai Chunxiang 
Published: December 2022

AbstractCryptocaryon irritans causes one of the most serious diseases in various wild and cultured marine fish, leading to mass mortality and economic loss. In this study, hydroxyl radical (•OH) solution produced by strong ionization discharge combined with water jet cavitation effect was injected into orange‐spotted grouper (Epinephelus coioides) aquaculture tanks for C. irritans control. The results showed that all C. irritans theronts were inactivated by •OH solution at concentrations of 0.5 mg/L within 2 min. •OH could induce alteration of shape, the absence of motility and macronucleus dispersion in theronts. A possible explanation was that the macronucleus of C. irritans might be damaged by •OH; as a result, its metabolism and life activities were disturbed. The •OH treatment increased the survival rate of E. coioides challenged with C. irritans from 64.7 ± 8.0% (mean ± SD) to 100% and reduced their infection intensity significantly. Stress response biomarkers such as malonaldehyde, glutathione, glutathione peroxidase, superoxide dismutase (SOD) and catalase levels in the gills of E. coioides at different time points were analysed. The SOD activity in the •OH group first decreased and then recovered to the initial level at the end of the experiment. The other stress response biomarkers had no significant difference from that in the uninfected control group after •OH treatment. Additionally, the gill of E. coioides in the •OH group exhibited slight and reversible transformation compared with the uninfected control group. Compared with •OH treatment, chlorine dioxide and formalin treatment reduced the survival rate, induced oxidative damage and changed the histological gill structure in E. coioides. In conclusion, •OH could be applied effectively to control C. irritans infection without affecting the normal physiological condition of E. coioides.
Truly dorsostable runners: Vertebral mobility in rhinoceroses, tapirs, and horses
Authors: Belyaev Ruslan I. , Kuznetsov Alexander N. , Prilepskaya Natalya E. 
Published: December 2022

AbstractThe vertebral column is a hallmark of vertebrates; it is the structural basis of their body and the locomotor apparatus in particular. Locomotion of any vertebrate animal in its typical habitat is directly associated with functional adaptations of its vertebrae. This study is the first large‐scale analysis of mobility throughout the presacral region of the vertebral column covering a majority of extant odd‐toed ungulates from 6 genera and 15 species. In this study, we used a previously developed osteometry‐based method to calculate available range of motion. We quantified all three directions of intervertebral mobility: sagittal bending (SB), lateral bending (LB), and axial rotation (AR). The cervical region in perissodactyls was found to be the most mobile region of the presacral vertebral column in LB and SB. Rhinoceroses and tapirs are characterized by the least mobile necks in SB among odd‐toed and even‐toed ungulates. Equidae are characterized by very mobile necks, especially in LB. The first intrathoracic joint (T1–T2) in Equidae and Tapiridae is characterized by significantly increased mobility in the sagittal plane compared to the typical thoracic joints and is only slightly less mobile than typical cervical joints. The thoracolumbar part of the vertebral column in odd‐toed ungulates is very stiff. Perissodactyls are characterized by frequent fusions of vertebrae with each other with complete loss of mobility. The posterior half of the thoracic region in perissodactyls is characterized by especially stiff intervertebral joints in the SB direction. This is probably associated with hindgut fermentation in perissodactyls: the sagittal stiffness of the posterior thoracic region of the vertebral column is able to passively support the hindgut heavily loaded with roughage. Horses are known as a prime example of a dorsostable galloper among mammals. However, based on SB in the lumbosacral part of the backbone, equids appear to be the least dorsostable among extant perissodactyls; the cumulative SB in equids and tapirs is as low as in the largest representatives of artiodactyls, while in Rhinocerotidae it is even lower representing the minimum across all odd‐toed and even‐toed ungulates. Morphological features of small Paleogene ancestors of rhinoceroses and equids indicate that dorsostability is a derived feature of perissodactyls and evolved convergently in the three extant families.
A Modified Endoscopic Technique with Three Incisions for Rockwood Types III and V Acromioclavicular Joint Dislocation
Authors: Huang Jianming , Huang Danlei , Wang Jun , Ye Zhiyang , Liu Haoyuan 
Published: December 2022

ObjectiveAcromioclavicular joint dislocation is one of the most common shoulder injuries in young men. With the advancement of minimally invasive technology, arthroscopy of acromioclavicular joint dislocation has been recognized for its good curative effect. This study aimed to explore the technical details and clinical efficacy of a modified minimally invasive endoscopic treatment for acromioclavicular joint dislocation.MethodsClinical data of patients receiving the three‐incision endoscopic treatment were retrospectively reviewed between July 2013 and July 2019. A total of 72 patients with acromioclavicular joint dislocation of Rockwood type III (n = 42) and type V (n = 30) were included in this study. Postoperative routine radiography was performed to evaluate acromioclavicular joint reduction and fixation. In addition, functional recovery of the shoulder joint was assessed using the American Shoulder and Elbow Surgeons (ASES) and Constant–Murley scores. Differences between the preoperative and postoperative data were compared using paired t‐tests.ResultsAll patients underwent loop plate elastic fixation under endoscopy during 24 to 48 months of follow‐up. Postoperative radiography showed that the acromioclavicular joint achieved anatomical reduction. The ASES score (91.1 ± 4.2) was significantly improved compared to the preoperative ASES score (62.4 ± 3.1) (t = 46.65, P < 0.0001). The Constant–Murley score (93.1 ± 4.6) was also significantly higher than that before the operation (40.7 ± 6.4) (t = 56.41, P < 0.0001). No postoperative complications occurred. During follow‐up, four patients had mild acromioclavicular joint degeneration but no obvious pain symptoms.ConclusionThe modified three‐incision endoscopic technique optimizes the surgical incision, reduces trauma, is minimally invasive, and provides rapid rehabilitation with satisfactory clinical outcomes.
Anatomical Imaging Study on Uneven Settlement of the Proximal Tibia
Authors: Wang Zhijie , Zheng Yi , Meng Decheng , Li Handi , Ji Chenni , Wang Juan 
Published: December 2022

ObjectiveUneven settlement of the proximal tibia significantly contributes to the onset and progression of medial compartment knee OA; however, the specific location and variations of proximal tibial deformity remain unclear. Therefore, this study aimed to explore the effects of the anatomic morphology of different tibial regions on proximal tibial vara and proximal tibial microstructural changes with age in both sexes to reveal the pattern of uneven settlement of the proximal tibia.MethodsIn this retrospective study, we reviewed the radiographs of 414 patients (789 legs) between May and September 2021. The medial proximal tibial angle (MPTA) and four anatomic angles of the tibia (i.e., the tibial plateau‐epiphyseal line [PT‐EL] angle, epiphyseal line‐tibial platform [EL‐PF] angle, epiphyseal axis inclination angle [EAIA], and subepiphyseal axis inclination angle [SAIA]) were measured. The effect of each angle on MPTA and their changes with age in both sexes were investigated using Pearson's correlation coefficient and multiple linear regression.ResultsIn females, PT‐EL angle, EL‐PF angle, and SAIA negatively correlated with MPTA (r = −0.325, −0.246, and −0.502; p < 0.05), and EAIA positively correlated with MPTA (r = 0.099, p < 0.05). Regression analysis showed that the correlations between MPTA and PT‐EL angle, EL‐PF angle, and SAIA were significant (β = −1.003, −0.013, and −0.971; adjusted R2 = 0.979). Furthermore, MPTA negatively correlated with age (r = −0.202, p < 0.05); PT‐EL angle and EAIA positively correlated with age (r = 0.237 and 0.142, p < 0.05). Regression analysis showed that only the correlation between PT‐EL angle and age was significant (β = 5.635, p < 0.05). In males, PT‐EL angle, EL‐PF angle, and SAIA negatively correlated with MPTA (r = −0.270, −0.267, and −0.533; p < 0.05), and EAIA positively correlated with MPTA (r = 0.135, p < 0.05). Regression analysis showed that the correlations between MPTA and PT‐EL angle, EL‐PF angle, and SAIA were significant (β = −0.992, −0.017, and −0.958; adjusted R2 = 0.970). However, there was no significant correlation between age and any of the measured angles (p > 0.05).ConclusionsProximal tibial vara is affected by the anatomic morphology of the epiphyseal and subepiphyseal regions. In females, the uneven settlement of the epiphysis progresses with age and may be responsible for dynamic varus deformity of the proximal tibia.
Self‐induced panniculitis in adolescence: Three cases and review of the literature
Authors: Lie Cheryl J. L. , Marimuttu Vicknesan J. , Wee Lynette W. Y. , Ho Valerie P. Y. , Gan Emily Y. , Alagappan Uma , Wong Sharon M. Y. , Koh Mark J. A. 
Published: December 2022

AbstractSelf‐induced trauma is a rare cause of panniculitis in adolescents and may be associated with undiagnosed underlying psychological conditions. The condition often poses a diagnostic challenge as patients usually present with non‐specific signs and symptoms, and often a concealed history of self‐induced trauma. Here, we present three adolescent patients with self‐induced traumatic panniculitis. All three patients were repeatedly admitted with non‐specific cutaneous lesions as well as multiple somatic complaints. After extensive evaluation to exclude organic causes, psychiatric assessment eventually revealed underlying psychosomatic disorders as a cause of the self‐induced trauma.
SARS‐CoV‐2 RNA positive pediatric organ donors: A case report
Authors: Clark Jonna D. , Albers Erin L. , Albert Jesselle E. , Berkman Emily R. , Englund Janet A. , Farris Reid W. D. , Johnson Beth A. , Lewis‐Newby Mithya , McGuire John , Rogers Meg , Thompson Holly M. , Wagner Thor A. , Wells Candy , Yanay Ofer , Zerr Danielle M. , Limaye Ajit P. 
Published: December 2022

AbstractBackgroundPreliminary evidence suggests that non‐lung organ donation from resolved, asymptomatic or mildly symptomatic SARS‐CoV‐2 infected adults may be safe. However, several biological aspects of SARS‐CoV‐2 infection differ in children and the risk for transmission and outcomes of recipients from pediatric donors with SARS‐CoV‐2 infection are not well described.MethodsWe report two unvaccinated asymptomatic pediatric non‐lung organ deceased donors who tested positive for SARS‐CoV‐2 RNA by RT‐PCR. Donor One unexpectedly had SARS‐CoV‐2 RNA detected in nasopharyngeal swab and plasma specimens at autopsy despite several negative tests (upper and lower respiratory tract) in the days prior to organ recovery. Donor Two had SARS‐CoV‐ 2 RNA detected in multiple nasopharyngeal swabs but not lower respiratory tract specimens (endotracheal aspirate and bronchoalveolar lavage) during routine surveillance prior to organ recovery and was managed with remdesivir and monoclonal antibodies prior to organ recovery.ResultsTwo hearts, two livers and four kidneys were successfully transplanted into seven recipients. No donor to recipient transmission of SARS‐CoV‐2 was observed and graft function of all organs has remained excellent for up to 7 months of followup.ConclusionsDue to the persistent gap between organ availability and the number of children waiting for transplants, deceased pediatric patients with non‐disseminated SARS‐CoV‐2 infection, isolated to upper and/or lower respiratory tract, should be considered as potential non‐lung organ donors.
Emergency care for youth who experience suicidality and identify as LGBTQ+
Authors: Schultz Theresa Ryan , Zoucha Rick , Sekula Kathleen , Abrams Bishop Allyson D. 
Published: December 2022

AbstractIntroductionSuicide is a leading cause of death in children; youth who identify as LGBTQ+ are at an exponentially higher risk of suicide. The purpose of this study was to explore the lived experiences of youth who identify as LGBTQ+ and sought emergency care for suicidality as adolescents.MethodsHermeneutics phenomenology is the research method used in this study. Youth who identify as LGBTQ+ and sought emergency treatment for suicidality when they were adolescents were recruited; fifteen youth enrolled. Individuals ranged in age from 20 to 25 years. Participants described their gender identity as male, female, non‐binary, transgender female, and their sexual orientation as: female, demisexual, bisexual, gay, homosexual, lesbian, queer, asexual, and transgender.ResultsThis study establishes that youth who identify as LGBTQ+ seeking emergency care for suicidality value: coping and control, acceptance from others and self, communicating with me about me, and moving beyond danger and distress. Lack of psychological safety—from the emic perspective—emerged as a critical finding.ConclusionThis research has strong implications for public health, policy, and research. Future research must seek to understand ways in which psychological safety is assessed in healthcare if we are to more deeply understand and effectively address the impact on health equity.
Prosthodontic restoration of a COVID‐19 associated mucormycosis defect: A clinical report
Authors: Artopoulou Ioli Ioanna , Kalfarentzos Evangelos , Polyzois Gregory , Perisanidis Christos 
Published: December 2022

AbstractIntroductionCoronavirus Disease 2019 (COVID‐19) pandemic brought the clinical practice of dentistry and prosthodontics at the threshold of a new era, due to the increasing prevalence of a relative rare condition normally affecting the immunocompromised patients.AimThe aim of this clinical case report is to briefly describe the etiopathogenesis, the surgical and prosthodontic management of this evolving medical condition emphasizing the emerging role of the maxillofacial prosthodontist in restoring the patients' well‐being.Methods and ResultsThe surgical and prosthodontic rehabilitation of a COVID‐19 infected patient with a mucormycotic lesion of the maxilla will be presented.ConclusionThe role of the maxillofacial prosthodontist is important in alleviating this severe COVID‐19 associated morbidity.
Combined Effects of Hypocapnic Hyperventilation and Hypoxia on Exercise Performance and Metabolic Responses During the Wingate Anaerobic Test
Authors: Dobashi Kohei , Katagiri Akira , Fujii Naoto , Nishiyasu Takeshi 
Published: December 2022

Hypoxia during supramaximal exercise reduces aerobic metabolism with a compensatory increase in anaerobic metabolism without affecting exercise performance. A similar response is elicited by preexercise voluntary hypocapnic hyperventilation, but it remains unclear whether hypocapnic hyperventilation and hypoxia additively reduce aerobic metabolism and increase anaerobic metabolism during supramaximal exercise. To address that issue, 12 healthy subjects (8 males and 4 females) performed the 30-second Wingate anaerobic test (WAnT) after (1) spontaneous breathing in normoxia (control, ∼21% fraction of inspired O2 [FiO2]), (2) voluntary hypocapnic hyperventilation in normoxia (hypocapnia, ∼21% FiO2), (3) spontaneous breathing in hypoxia (hypoxia, ∼11% FiO2), or (4) voluntary hypocapnic hyperventilation in hypoxia (combined, ∼11% FiO2). Mean power output during the 30-second WAnT was similar among the control (561 [133] W), hypocapnia (563 [140] W), hypoxia (558 [131] W), and combined (560 [133] W) trials (P = .778). Oxygen uptake during the 30-second WAnT was lower in the hypocapnia (1523 [318] mL/min), hypoxia (1567 [300] mL/min), and combined (1203 [318] mL/min) trials than in the control (1935 [250] mL/min) trial, and the uptake in the combined trial was lower than in the hypocapnia or hypoxia trial (all P < .001). Oxygen deficit, an index of anaerobic metabolism, was higher in the hypocapnia (38.4 [7.3] mL/kg), hypoxia (37.8 [6.8] mL/kg), and combined (40.7 [6.9] mL/kg) trials than in the control (35.0 [6.8] mL/kg) trial, and the debt was greater in the combined trial than in the hypocapnia or hypoxia trial (all P < .003). Our results suggest that voluntary hypocapnic hyperventilation and hypoxia additively reduce aerobic metabolism and increase anaerobic metabolism without affecting exercise performance during the 30-second WAnT.