bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of liver stiffness measurement and ultrasound findings change during inotuzumab ozogamicin cycles for relapsed or refractory acute lymphoblastic leukemia
Authors: Ravaioli Federico , Marconi Giovanni , Martinelli Giovanni , Dajti Elton , Sartor Chiara , Abbenante Maria Chiara , Alemanni Luigina Vanessa , Nanni Jacopo , Rossini Benedetta , Parisi Sarah , Colecchia Luigi , Cristiano Gianluca , Marasco Giovanni , Vestito Amanda , Paolini Stefania , Bonifazi Francesca , Curti Antonio , Festi Davide , Cavo Michele , Colecchia Antonio , Papayannidis Cristina 
Published: December 2021

AbstractIn adult patients, acute lymphoblastic leukemia (ALL) is a rare hematological cancer with a cure rate below 50% and frequent relapses. With traditional therapies, patients with relapsed or refractory (R/R) ALL have a survival that may be measured in months; in these patients, inotuzumab ozogamicin (IO) is an effective therapy. IO was linked to increased risk of veno‐occlusive disease/sinusoid obstruction syndrome (VOD/SOS), liver injury, and various grade of liver‐related complications during clinical trials and real‐life settings; however, hepatologic monitoring protocol is not established in this population. In our institution, 21 patients who received IO (median of 6 doses of IO administered) for R/R ALL were prospectively followed for hepatologic surveillance, including clinical evaluation, ultrasonography, and liver stiffness measurement (LSM) biochemistry. After a median follow‐up of 17.2 months, two SOS events were reported (both after allogeneic transplant) as IO potentially related clinically relevant adverse event. Mild alterations were reported in almost the totality of patients and moderate‐severe liver biochemical alterations in a quarter of patients. Within biochemicals value, AST and ALP showed an augment related to IO administration. LSM linearly augmented for each IO course administered. Baseline LSM was related to liver‐related changes, especially with the severity of portal hypertension (PH)‐related complications. Pre‐transplant LSM was higher in patients receiving IO when compared with a control cohort. PH‐related complications were discovered in nearly 77% of patients, with clinically significant PH occurrence and development of ascites in 38% and 14%, respectively. This prospective experience constitutes the rationale to design a hepatologic monitoring program in patients receiving IO. LSM may be of pivotal importance in this program, constituting a rapid and effective screening that quantitatively correlates with liver alterations.
Hydrogen Adsorption/Desorption Isotherms on Supported Platinum Nanoparticles Determined by in‐situ XAS and ΔXANES Analysis
Authors: Fujita Masami , Yamamoto Akira , Tsuchiya Naoki , Yoshida Hisao 
Published: December 2021

AbstractHydrogen atoms on supported metal nanoparticles (NPs) play a significant role in heterogeneous catalysis. Despite the extensive previous research, however, the adsorption of hydrogen onto practical supported NP catalysts is still unclear especially in the atmospheric pressure conditions. In this study, adsorption/desorption isotherms of hydrogen on Pt NPs supported on alumina (Al2O3) were obtained in gas‐flow conditions using the analysis of the difference spectra of Pt LIII‐edge X‐ray absorption spectroscopy (XAS) at 303 K. From the analysis of extended X‐ray absorption fine structure (EXAFS), a positive linear relationship was observed between the hydrogen coverage and Pt−Pt bond distance. Additionally, the re‐adsorption experiment of hydrogen after the first adsorption/desorption cycle and the transient change of dispersive XAS spectra in the hydrogen adsorption suggests that the hydrogen adsorption induces the surface reconstruction of Pt NPs on Al2O3 at around room temperature and atmospheric pressure.
Transient Modeling and Simulation of a Multiple‐Stage Evaporator in the Paper Industry
Authors: Pati Smitarani , Verma Om Prakash , Arya Raj Kumar , Tiwari Anurag Kumar 
Published: December 2021

AbstractThe present work investigates the energy performance analysis of a heptad‐based multiple‐stage evaporator (MSE) under steady and transient conditions, integrated with different energy reduction schemes (such as steam split, feed split, and feed preheater). The steady‐state analysis was performed to optimize the steam economy subjected to the developed steady‐state energy models as the equality constraints. The simulated optimization is a maximization problem and is solved by Interior‐Point Optimizer and Gray Wolf Optimizer on two different platforms, GAMS and MATLAB, respectively. Further, transient and stability analyses were performed by developing and representing the nonlinear dynamic energy models to the state‐space representation using linearization.
Centralized Proportional Integral Controller Design for the Activated Sludge Process
Authors: Anchan Sanjith S. , Sankar Rao Chinta 
Published: December 2021

AbstractThe design of a centralized proportional integral controller for a single‐tank activated sludge process is presented. The relative normalized gain array (RNGA) and dynamic relative gain array (dRGA) were adopted for enhancing the closed‐loop performance of a multivariable system. The dRGA method gave superior and acceptable responses compared to the RNGA method. The designated error indices decreased significantly for the dRGA method compared with the RNGA method. The dRGA method is simple and effective, since it considers the process dynamics to provide an accurate interaction assessment. The designed centralized controller overcomes the limitations of the decoupler for stability challenges when compared with decentralized controllers.
Perceiving university students' opinions from Google app reviews
Authors: Ranjan Sakshi , Mishra Subhankar 
Published: December 2021

AbstractGoogle app market captures the school of thought of users from every corner of the globe via ratings and text reviews, in a multilinguistic arena. The critique's viewpoint regarding an app is proportional to their satisfaction level. The potential information from the reviews cannot be extracted manually, due to its exponential growth. So, sentiment analysis, by machine learning and deep learning algorithms employing NLP, explicitly uncovers and interprets the emotions. This study performs the sentiment classification of the app reviews and identifies the university students' behavior toward the app market via exploratory analysis. We applied machine learning algorithms using the TP, TF, and TF‐IDF text representation scheme and evaluated its performance on Bagging, an ensemble learning method. We used word embedding, GloVe, on the deep learning paradigms. Our model was trained on Google app reviews and tested on students' app reviews (SAR). The various combinations of these algorithms were compared among each other using F‐score and accuracy and inferences were highlighted graphically. SVM, among other classifiers, gave fruitful accuracy (93.41%), F‐score (0.89) on bi‐gram + TF‐IDF scheme. Bagging enhanced the performance of LR and NB with accuracy 87.88% and 86.69% and F‐score 0.86 and 0.78 respectively. Overall, LSTM on Glove embedding recorded the highest accuracy (95.2%) and F‐score (0.88).
Biofortified wheat: Harnessing genetic diversity for improved nutritional quality to eradicate hidden hunger
Authors: Kaur Kuldeep , Sharma Achla , Mavi Gurvinder Singh , Srivastava Puja , Kaur Harinderjeet , Sharma Himanshu , Singh Satinder , Kushwah Ashutosh , Sohu Virinder Singh 
Published: December 2021

AbstractThe present study is based on backcross introgression lines carrying high grain zinc (Zn) quantitative trait loci (QTL) introgressed from domestic einkorn wheat (Triticum monococcum L.) and wild einkorn wheat (T. boeoticum) in the background of high‐yielding wheat (T. aestivum L.) cultivars of India. Initially, individual trials each for BC1F3 and BC2F3 progenies from different cross combinations were evaluated for grain Zn concentration, yellow pigment content (YPC) and agronomic traits. Highly promising BC1F3 and BC2F3 progenies were identified and advanced in off‐season as ear to progeny rows. A total of 42 BC1F5 and 43 BC2F5 derivatives were evaluated in a single trial where the BC1F5 progenies from recipient parent WH1105 and tetraploid parent Donor 2 were recorded with highest grain Zn (64.1–67.9 ppm) showing up to 35.8% enhancement over recipient. The highest grain YPC (5.35 ppm) was observed for BC1F5 progenies from the cross involving PBW703 (3.34 ppm) as recipient and Donor 7 (6.32 ppm) as tetraploid donor parent. Monitoring of backcross derivatives with the marker YP7A‐2 linked to yellow pigment gene Psy‐A1, also revealed nine lines positive for high yellow pigment allele (Psy‐A1c) indicating introgression from durum wheat (T. durum Desf.). Nineteen high Zn derivatives were shortlisted and selfed for 2 yr (2017–2018 and 2018–2019) to get desirable homozygosity and preliminary yield evaluation was conducted for two consecutive years (2019–2020 and 2020–2021). Introgression lines in the background of PBW698 (IL8 and IL17) were recorded with the highest Zn concentration (51.37 and 51.30 ppm) indicating 55.90% increment over recipient parent with good agronomic performance. These biofortified introgression wheat lines can contribute to mitigating the malnutrition among the masses in developing countries.
The role of endoscopy in the management of gastroesophageal reflux disease
Authors: Kuribayashi Shiko , Hosaka Hiroko , Nakamura Fumihiko , Nakata Ko , Sato Keigo , Itoi Yuki , Hashimoto Yu , Kasuga Kengo , Tanaka Hirohito , Uraoka Toshio 
Published: December 2021

AbstractGastroesophageal reflux disease (GERD) is a common disease that may cause a huge economic burden. Endoscopy is performed not only to rule out other organic diseases but also to diagnose reflux esophagitis or Barrett's esophagus. Non‐erosive GERD (non‐erosive reflux disease [NERD]) is called endoscopy‐negative GERD; however, GERD‐related findings could be obtained through histological assessment, image‐enhanced endoscopy, and new endoscopic modalities in patients with NERD. Moreover, endoscopy is useful to stratify the risk for the development of GERD. In addition, endoscopic treatments have been developed. These techniques could significantly improve patients’ quality of life as well as symptoms.
Participation and politics in transboundary hydropower development: The case of the Pak Beng dam in Laos
Authors: Suhardiman Diana , Geheb Kim 
Published: December 2021

AbstractHydropower development in the lower Mekong Basin is being rapidly developed. Taking the Pak Beng hydropower project in Laos as a case study, this paper looks at participation and politics in transboundary hydropower development, how the latter is revealed by multiple, parallel institutional architectures in hydropower decision‐making across scales, and its implications for transboundary environmental governance. We look at the institutional disjuncture in hydropower decision‐making, how it is (re)produced by powerful, albeit conflicting narratives at respectively national and transboundary levels, power relations shaping these narratives, and how these translate into local community's limited ability to convey their voices and represent their development needs. Conceptually, the paper sheds light on the underlying politics in transboundary environmental governance by bringing to light the structural factors that prevent participation, including how these factors are justified, sustained and to a certain extent reproduced as an integral part of legal, policy, and institutional landscapes that govern hydropower decision‐making across scales (e.g., local to transboundary).
Brisk walking can be a maximal effort in heart failure patients: a comparison of cardiopulmonary exercise and 6 min walking test cardiorespiratory data
Authors: Mapelli Massimo , Salvioni Elisabetta , Paneroni Mara , Gugliandolo Paola , Bonomi Alice , Scalvini Simonetta , Raimondo Rosa , Sciomer Susanna , Mattavelli Irene , La Rovere Maria Teresa , Agostoni Piergiuseppe 
Published: December 2021

AbstractAimsCardiopulmonary exercise test (CPET) and 6 min walking test (6MWT) are frequently used in heart failure (HF). CPET is a maximal exercise, whereas 6MWT is a self‐selected constant load test usually considered a submaximal, and therefore safer, exercise, but this has not been tested previously. The aim of this study was to compare the cardiorespiratory parameters collected during CPET and 6MWT in a large group of healthy subjects and patients with HF of different severity.Methods and resultsSubjects performed a standard maximal CPET and a 6MWT wearing a portable device allowing breath‐by‐breath measurement of cardiorespiratory parameters. HF patients were grouped according to their CPET peak oxygen uptake (peakV̇O2). One hundred and fifty‐five subjects were enrolled, of whom 40 were healthy (59 ± 8 years; male 67%) and 115 were HF patients (69 ± 10 years; male 80%; left ventricular ejection fraction 34.6 ± 12.0%). CPET peakV̇O2 was 13.5 ± 3.5 mL/kg/min in HF patients and 28.1 ± 7.4 mL/kg/min in healthy subjects (P < 0.001). 6MWT‐V̇O2 was 98 ± 20% of the CPET peakV̇O2 values in HF patients, while 72 ± 20% in healthy subjects (P < 0.001). 6MWT‐V̇O2 was >110% of CPET peakV̇O2 in 42% of more severe HF patients (peakV̇O2 < 12 mL/kg/min). Similar results have been found for ventilation and heart rate. Of note, the slope of the relationship between V̇O2 at 6MWT, reported as a percentage of CPET peakV̇O2 vs. 6MWT V̇O2 reported as the absolute value, progressively increased as exercise limitation did.ConclusionsIn conclusion, the last minute of 6MWT must be perceived as a maximal or even supramaximal exercise activity in patients with more severe HF. Our findings should influence the safety procedures needed for the 6MWT in HF.
Ligand Field Theory for Linear ML2Complexes
Authors: Deeth Robert J. 
Published: December 2021

AbstractPoint‐charge crystal field theory (CFT) for linear ML2systems guarantees dz2>dxz/dyz>dxy/dx2‐y2 (i. e. dσ>dπ>dδ). This is not what is found for CuCl2and other linear, divalent MX2complexes where dπ>dσ. This failure of CFT has also been attributed to its successor, ligand field theory (LFT). However, taking LFT to be parameterised CFT, any d orbital sequence is possible. The real test is whether the LFT parameters make chemical sense. A new cellular ligand field (CLF) analysis of CuCl2, including the equatorial toroidal void, which affects all the d orbitals, confirms eπ(Cl)>eσ(Cl). To account for this, the ‘distributed donation’ model is proposed linking σ and π bonding such that enhanced π donation is at the expense of reduced σ bonding and vice versa. This is the π‐donor analogue of the Dewar‐Chatt‐Duncanson model for π‐acceptor ligands. Ab initio LFT (AI LFT) calculations support a progressive π‐donation increase/σ donation decrease from Cu(II) to Sc(II) with eσfinally becoming negative. The model further predicts that adding equatorial ligands will force the π density back into the σ bond which is also confirmed by AI LFT calculations fortrans‐[CuCl2(NH3)4] where eσ(Cl)>eπ(Cl) even though the CuCl2unit is unchanged. The distributed donation model for linear σ‐only [MII(Lσ)2]nsystems (Lσ=NH3, H), where increasing π donation is not possible, implies that the M−L bonding in linear systems should be inherently weak.
Predictors of non‐completion of a day treatment program for adults with eating disorders
Authors: Thaler Lea , Booij Linda , Burnham Nuala , Kenny Samantha , Oliverio Stephanie , Israel Mimi , Steiger Howard 
Published: December 2021

AbstractAlthough treatment dropout is common among patients with eating disorders, very few studies have examined predictors of non‐completion in day treatment. We investigated various potential predictors of dropout from adult day treatment. Participants were 295 adult patients with a diagnosis of Anorexia Nervosa (restricting or binge‐eating/purging subtype), Bulimia Nervosa (BN), Other Specified Feeding or Eating Disorder, or Avoidant Restrictive Food Intake Disorder. Predictors included eating‐disorder characteristics, motivation at the commencement of treatment, Body Mass Index (BMI), time spent in treatment and personality dimensions. Logistic regression analyses showed that for patients with a BMI of less than 20 at the start of treatment, low BMI was a significant predictor of staff‐initiated termination due to not meeting weight gain goals. Furthermore, completing less than 6 weeks of treatment was associated with staff‐initiated termination. For the whole sample, those with higher changes in weight over the course of treatment were less likely to terminate prematurely. None of the other predictor variables yielded significant results. Results of the current study highlight characteristics of patients who are more likely not to complete day treatment and can help identify patients who may be at risk for not succeeding in multi‐diagnostic day treatment programs.
Modelling the effects of normal faulting on alluvial river meandering
Authors: Woolderink Hessel A. G. , Weisscher Steven A. H. , Kleinhans Maarten G. , Kasse Cornelis , van Balen Ronald T. 
Published: December 2021

AbstractThe meandering of alluvial rivers may be forced by normal faulting due to tectonically altered topographic gradients of the river valley and channel at and near the fault zone. Normal faulting can affect river meandering by either instantaneous (e.g. surface‐rupturing earthquakes) or gradual displacement. To enhance our understanding of river channel response to tectonic faulting at the fault zone scale we used the physics‐based, two‐dimensional morphodynamic model Nays2D to simulate the responses of a laboratory‐scale alluvial river with vegetated floodplain to various faulting and offset scenarios. The results of a model with normal fault downstepping in the downstream direction show that channel sinuosity and bend radius increase up to a maximum as a result of the faulting‐enhanced valley gradient. Hereafter, a chute cutoff reduces channel sinuosity to a new dynamic equilibrium value that is generally higher than the pre‐faulting sinuosity. A scenario where a normal fault downsteps in the upstream direction leads to reduced morphological change upstream of the fault due to a backwater effect induced by the faulting. The position within a meander bend at which faulting occurs has a profound influence on the evolution of sinuosity; fault locations that enhance flow velocities over the point bar during floods result in a faster sinuosity increase and subsequent chute cutoff than locations that enhance flow velocity directed towards the floodplain. This upward causation from the bend scale to the reach and floodplain scale arises from the complex interactions between meandering and floodplain and the nonlinearities of the sediment transport and chute cutoff processes. Our model results provide a guideline to include process‐based reasoning in the interpretation of geomorphological and sedimentological observations of fluvial response to faulting. The combination of these approaches leads to better predictions of possible effects of faulting on alluvial river meandering.
Frequent origins of traumatic insemination involve convergent shifts in sperm and genital morphology
Authors: Brand Jeremias N. , Harmon Luke J. , Schärer Lukas 
Published: December 2021

AbstractTraumatic insemination is a mating behavior during which the (sperm) donor uses a traumatic intromittent organ to inject an ejaculate through the epidermis of the (sperm) recipient, thereby frequently circumventing the female genitalia. Traumatic insemination occurs widely across animals, but the frequency of its evolution, the intermediate stages via which it originates, and the morphological changes that such shifts involve remain poorly understood. Based on observations in 145 species of the free-living flatworm genus Macrostomum, we identify at least nine independent evolutionary origins of traumatic insemination from reciprocal copulation, but no clear indication of reversals. These origins involve convergent shifts in multivariate morphospace of male and female reproductive traits, suggesting that traumatic insemination has a canalizing effect on morphology. We also observed sperm in both the sperm receiving organ and within the body tissue of two species. These species had intermediate trait values indicating that traumatic insemination evolves through initial internal wounding during copulation. Finally, signatures of male-female coevolution of genitalia across the genus indicate that sexual selection and sexual conflict drive the evolution of traumatic insemination, because it allows donors to bypass postcopulatory control mechanisms of recipients.
Thermophoretic particle deposition and heat generation analysis of Newtonian nanofluid flow through magnetized Riga plate
Authors: Madhukesh Javali K. , Varun Kumar Ravikumar S. , Punith Gowda Ramanahalli J. , Prasannakumara Ballajja C. , Shehzad Sabir A. 
Published: December 2021

AbstractThe Riga surface is composed of an electromagnetic actuator that comprises a span‐wise associated array of discontinuous electrodes and an everlasting magnet mounted over a planer surface. The electro‐magneto‐hydrodynamic has an attractive role in thermal reactors, fluidics network flow, liquid chromatography, and micro coolers. Inspired by these applications, a laminar, two‐dimensional nanofluid flow with uniform heat sink‐source, thermophoretic depositions of the particles, and the Newtonian heating effect are investigated. The equations that describe the fluid motion are reduced into a system of ordinary differential equations with the help of spatial similarity variables. Numeric solutions of ordinary differential equations are executed through the Runge–Kutta–Felhberg 45 order technique via a shooting scheme. The role of various nondimensional factors on physically interesting quantities is elaborated graphically. The velocity profile rises for modified Hartmann number and decreases for porosity parameter. Thermal enhancement is high in the common wall temperature condition comparative to the case of the Newtonian heating conditions. The concentration profile is enhanced with Schmidt number, but the reverse trend is observed for the thermophoretic parameter. The rate of mass transfer is increased with Schmidt number.