bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and severity of thrombocytopenia associated with use of intravascular microaxial ventricular assist devices for treatment of cardiogenic shock
Authors: Goetz Jenna , O'Brien Michael , Bream‐Rouwenhorst Heather , Toyoda Alexander , Hobbs Ryan , Horwitz Phillip A. 
Published: December 2022

AbstractIntroductionThe use of temporary mechanical circulatory support (MCS) for patients with refractory cardiogenic shock has increased over the past decade. Impella devices (intravascular microaxial ventricular assist devices [VADs]) have become common MCS options but reportedly cause thrombocytopenia. Limited published data regarding the incidence or severity of microaxial VAD‐associated thrombocytopenia exists.ObjectivesThe goal of this study was to determine the incidence, timing, and severity of thrombocytopenia in a microaxial VAD population.MethodsA retrospective multicenter review of electronic medical records identified all patients implanted with microaxial VAD at three US academic teaching hospitals between June 2015 and August 2017. Patients were excluded for short‐term procedural microaxial VAD use during percutaneous coronary intervention.ResultsSixty‐four patients underwent microaxial VAD insertion (95% for left‐sided support) during the observed time period. Support was in place for a median duration of 5.2 (interquartile range [IQR]: 2.4–10.0) days. Within 7 days postinsertion, 98.5% of patients developed thrombocytopenia (platelet count <150,000/μl) and 81.3% of patients experienced a >50% platelet decrease. Average platelet count nadir was 68,200/μl or 63.9% from baseline occurring on median day 3.8 (IQR: 2.4–5.4). Twenty‐four patients (38.1%) were tested for heparin‐induced thrombocytopenia by the heparin‐dependent antibody (HDA) test. All HDAs were either negative or had serotonin release assay negative confirmation. Postdevice removal, platelet counts returned to baseline or >150,000/μl in 63% of patients by Day 5.ConclusionMicroaxial VAD‐associated thrombocytopenia is common. Practitioners should consider this when evaluating supported patients for other causes of thrombocytopenia. Platelet counts return to preimplantation levels within days of device removal.
Usefulness of Gly m 4‐specific IgE test in the diagnosis of Rosaceae fruit‐oral allergy syndrome caused by Betulaceae pollen sensitization
Authors: Yoshida Tokiko , Morita Eishin , Chinuki Yuko , Kohno Kunie , Yamasaki Osamu 
Published: December 2022

AbstractBackgroundPollen‐food allergy syndrome (PFAS) is caused by the cross‐reaction of the specific IgE to pollen allergens with similar allergens contained in fruits, vegetable, and nuts. The representative allergen responsible for this cross‐reaction is pathogenesis‐related protein (PR)‐10. Specific IgE test using Gly m 4, soybean PR‐10, is widely used to diagnose soy allergy. We aimed to investigate whether the Gly m 4‐specific IgE test is useful for predicting oral allergy symptoms (OAS) to Rosaceae fruits in PFAS caused by Betulaceae pollen sensitization.MethodsForty‐one patients with suspected PFAS were enrolled. Specific IgE levels were measured against alder pollen, apple, peach, pear, and Gly m 4, and correlation between test results and allergic symptoms was assessed to compare the accuracy of these allergen‐specific IgE tests.ResultsOf the 41 patients, 32 were positive for alder pollen‐specific IgE. Of those, 16 showed OAS to at least one of apple, peach, and pear (OAS (+) group), and the rest 16 cases showed no symptoms (OAS (−) group). The Gly m 4‐specific IgE value was significantly higher in the OAS (+) group (p = .014), and the highest in area under the receiver operating characteristics curve. The cut‐off value for detection of the OAS (+) group was 2.65 UA/ml, with a sensitivity of 62.5% and a specificity of 81.3%. Other allergen‐specific IgE values were not significantly different between the two groups.ConclusionsIn the subjects sensitized to Betulaceae pollen allergens, the Gly m 4‐specific IgE test is useful for predicting OAS of Rosaceae fruits.
Chef, ich brauche mehr Geld
Authors: Kuntz Bernhard 
Published: December 2022

AbstractAufgrund der hohen Inflation werden zurzeit viele Arbeitnehmer bei ihren Chefs mit der Forderung nach einer Gehaltserhöhung vorstellig ‐ teils sogar mit Konkurrenz‐Angeboten. Wie sollten Arbeitgeber darauf reagieren
Staubfrei Mischen
Authors: Poller Stephan , Schluckebier Karl Hendrik 
Published: December 2022

AbstractDie kunststoffverarbeitende Industrie setzt das abrasive Weißpigment TiO2, das seit Oktober 2021 mit Inkrafttreten einer neuen EU‐Verordnung als krebserregend eingestuft ist, für unterschiedlichste Produkte ein. Dies können zum Beispiel PVC‐Compounds, Masterbatches oder Pulverlacke sein. Zeppelin bietet hierfür eine sichere und effiziente Mischtechnik an.
Aufs Gewicht geschaut
Authors: Hasselmann Matthias 
Published: December 2022

AbstractAufgrund ihrer Robustheit und Genauigkeit ist die gravimetrische Wägetechnik die optimale Methode zur Inhaltsbestimmung von Schüttgütern. Hinzu kommt bei der Dosierung der Vorteil, dass die Fördergeschwindigkeit verändert werden kann, ohne die Messwerte zu beeinflussen. Damit lässt sich die gravimetrische Methode in den unterschiedlichsten Branchen einsetzen, von Anwendungen in der Agrar‐ und Lebensmittelindustrie bis hin zur Chemischen Industrie und der Herstellung von Kosmetika.
Energiemanagement in der modularen Produktion
Authors: Reiche Leif‐Thore 
Published: December 2022

AbstractWas für monolithische Anlagen schon längst gängige Praxis ist, ist im Rahmen der modularen Produktion bisher ein Novum: Die Integration von Energiemanagementsystemen in das produktionstechnische Umfeld. Ein neuer Ansatz setzt auf die Erweiterung des MTP‐Konzepts.
Das Beste aus beiden Antriebswelten fusioniert
Authors: Väth Maximilian 
Published: December 2022

AbstractIm Interview mit CITplus erläutert Maximilain Väth, Assitent der Geschäftsleitung von WP‐ARO, worin die Vorteile der Entwicklung der neuen Pumpe sind und worin die Motivation für den Wechsel von Druckluft‐ auf Stromantrieb lag.
Adsorption of single‐ring model naphthenic acid from oil sands tailings pond water using physically activated petroleum coke
Authors: Sarkar Bithun , Fricska Hazel , Gao Qiyang , Tong Shitang , Jia Charles Q. 
Published: December 2022

AbstractPetroleum coke‐derived activated cokes were prepared and used for the adsorptive removal of a single‐ring naphthenic acid (NA) from synthetic oil sands process affected water (OSPW). CO2 activation produced carbon with a larger mesopore volume fraction (0.67) than steam activation (0.25). Interestingly, prolonging the activation time of CO2 from 6 to 9 h led to a simultaneous increase in specific surface area (276–405 m2/g) and mesopore volume (0.51–0.67). Furthermore, a positive relationship was found between the pseudo‐second‐order kinetic rate constant and the mesoporous volume of the activated coke. This suggests both the importance of pore size on kinetics and the fact that physical activation with a reagent such as CO2 may be better suited than chemical activation due to its ability to create mesopores. Although enlarging the pores and accelerating the adsorption rate, post‐oxidation had detrimental effects on adsorption capacity, resulting in a decrease in equilibrium adsorbed amount from 115 to 34 mg/g, a 70% decrease, when post‐oxidized with O2, due to the negative charge of oxygen‐containing functional groups. On the other hand, the measured adsorption capacity increased by over 60% when activated coke was treated with ammonia, a result of the positively charged nitrogen‐containing surface groups. Finally, in real OSPW, the activated coke had a much lower capacity for total acid‐extractable organics than for the model NA. Therefore, activated petroleum coke may not be the best choice for treating raw tailings pond water and may be better suited for polishing.
Real‐life data from standardized preanalytical coding (SPREC) in tissue biobanking and its dual use for sample characterization and process optimization
Authors: Skoworonska Magdalena , Blank Annika , Centeno Irene , Hammer Caroline , Perren Aurel , Zlobec Inti , Rau Tilman T 
Published: December 2022

AbstractThe standardized preanalytical code (SPREC) aggregates warm ischemia (WIT), cold ischemia (CIT), and fixation times (FIT) in a precise format. Despite its growing importance underpinned by the European in vitro diagnostics regulation or broad preanalytical programs by the National Institutes of Health, little is known about its empirical occurrence in biobanked surgical specimen. In several steps, the Tissue Bank Bern achieved a fully informative SPREC code with insights from 10,555 CIT, 4,740 WIT, and 3,121 FIT values. During process optimization according to LEAN six sigma principles, we identified a dual role of the SPREC code as a sample characteristic and a traceable process parameter. With this preanalytical study, we outlined real‐life data in a variety of organs with specific differences in WIT, CIT, and FIT values. Furthermore, our FIT data indicate the potential to adapt the SPREC fixation toward concrete paraffin‐embedding time points and to extend its categories beyond 72 h due to weekend delays. Additionally, we identified dependencies of preanalytical variables from workload, daytime, and clinics that were actionable with LEAN process management. Thus, streamlined biobanking workflows during the day were significantly resilient to workload peaks, diminishing the turnaround times of native tissue processing (i.e. CIT) from 74.6 to 46.1 min under heavily stressed conditions. In conclusion, there are surgery‐specific preanalytics that are surgico‐pathologically limited even under process optimization, which might affect biomarker transfer from one entity to another. Beyond sample characteristics, SPREC coding is highly beneficial for tissue banks and Institutes of Pathology to track WIT, CIT, and FIT for process optimization and monitoring measurements.
Retrospective study in US commercial sorghum breeding: I. Genetic gain in relation to relative maturity
Authors: Mayor Laura , Demarco Paula , Lira Sara , Fang Yinan , Abadie Tabare , Gambin Brenda L. , Hammer Graeme , Ciampitti Ignacio , Cooper Mark , Messina Carlos 
Published: December 2022

AbstractSorghum [Sorghum bicolor (L.) Moench] is an important staple food for human consumption and a source of animal feed in the semiarid regions of the world. Sustained positive rates of crop improvement are necessary to supply food and feed to a growing population. However, land allocated to sorghum and its inclusion in production systems has been in constant decline. Here we report the rate of sorghum genetic gain in a commercial breeding program in the United States and provide evidence that a modest yield improvement is an important factor limiting land allocation to this crop. A 6‐year study that evaluated 50 sorghum genotypes commercialized between the decades of 1960 and 2010 was conducted in 19 environments within the US Sorghum Belt region. Yield varied between 500 and 850 g m−2. Here we show a positive rate of genetic gain of 2.63 g m−2 y−1 on average across three different maturity groups grown in the United States. Rates ranged from 2.1 to 4.3 g m−2 y−1 across maturity groups. This result contrasts with a stagnant rate of crop improvement for many regions of the world, yet the rates are insufficient to reverse the negative trend in planted area. Breeding technologies are proposed to hasten genetic gain in sorghum to reverse the loss of on‐farm agricultural biodiversity.
Actions and approaches for enabling Industry 5.0‐driven sustainable industrial transformation: A strategy roadmap
Authors: Ghobakhloo Morteza , Iranmanesh Mohammad , Morales Manuel E. , Nilashi Mehrbakhsh , Amran Azlan 
Published: December 2022

AbstractAlthough Industry 4.0 was believed to promote sustainable development, it has ignored or misunderstood many prevailing sustainability concerns, which led to the emergence of the Industry 5.0 agenda. While the desirable sustainability values of Industry 5.0 are widely acknowledged, the knowledge of how this agenda can deliver sustainable transformation is lacking. The present study addresses this knowledge gap, explaining how Industry 5.0 transformation should be managed to facilitate sustainable development. Therefore, this study strives to model the underlying mechanism for enabling such transformation. The study conducted a content‐centric review of the literature and identified 11 actions and approaches that serve as enablers of Industry 5.0 transformation. The study further conducted the interpretive structural modeling and structured the enablers as an interpretive model explaining steps needed for enabling Industry 5.0. Finally, the study developed the strategy roadmap for enabling Industry 5.0 transformation and sustainable development. Results emphasized stakeholder salience, highlighting the enabling role of stakeholder integration and collaboration in Industry 5.0 transformation. Proactive governmental support is the most driving enabler of Industry 5.0, whereas eco‐innovation and sustainable value network reformation are among the most complex and hard‐to‐develop enablers. Results offer several implications for policymakers and practitioners, explaining the functionality of each approach and strategy necessary for Industry 5.0 transformation. The roadmap determines the sequential relationships among these approaches and strategies and identifies their optimal development sequence for enabling Industry 5.0 transformation synergistically. Results further identify the codependences among the Industry 5.0 transition enablers and highlight their interactions and complementarities.
Development of an Integrated System for Highly Selective Photoenzymatic Synthesis of Formic Acid from CO2
Authors: Xing Xiu , Liu Yan , Lin Ru‐De , Zhang Yang , Wu Zhong‐Liu , Yu Xiao‐Qi , Li Kun , Wang Na 
Published: December 2022

AbstractHerein, a Zr‐based dual‐ligand MOFs with pre‐installed Rh complex was employed for NADH regeneration in situ and also used for immobilization of formic acid dehydrogenase (FDH) in order to realize a highly efficient CO2 fixation system. Then, based on the detailed investigations into the photochemical and electrochemical properties, it is demonstrated that the introduction of the photosensitive meso‐tetra(4‐carboxyphenyl) porphin (TCPP) ligands increased the catalytic active sites and improved photoelectric properties. Furthermore, the electron mediator Rh complex, anchored on the zirconium‐based dual‐ligand MOFs, enhanced the efficiency of electron transfer efficiency and facilitated the separation of photogenerated electrons and holes. Compared with UiO‐66‐NH2, Rh‐H2TCPP‐UiO‐66‐NH2 exhibits an optimized valence band structure and significantly improved photocatalytic activity for NAD+ reduction, resulting the synthesis of formic acid from CO2 increased from 150 μg mL−1 (UiO‐66‐NH2) to 254 μg mL−1 (Rh‐H2TCPP‐UiO‐66‐NH2). Moreover, the assembled photocatalyst‐enzyme coupled system also allows facile recycling of expensive electron mediator, enzyme, and photocatalyst.
Higher literacy is associated with better white matter integrity and cognition in middle age
Authors: de Resende Elisa de Paula França , Xia Feng , Sidney Stephen , Launer Lenore J. , Schreiner Pamela J. , Erus Guray , Bryan Nick , Yaffe Kristine 
Published: December 2022

AbstractIntroductionLiteracy can be a better measure of quality of education. Its association with brain health in midlife has not been thoroughly investigated.MethodsWe studied, cross‐sectionally, 616 middle‐aged adults (mean age of 55.1 ± 3.6 years, 53% female and 38% Black) from the Coronary Artery Risk Development in Young Adults (CARDIA) study. We correlated literacy with cognitive tests, gray matter volumes, and fractional anisotropy (FA) values (indirect measures of white matter integrity) using linear regression.ResultsThe higher‐literacy group (n = 499) performed better than the low‐literacy group (n = 117) on all cognitive tests. There was no association between literacy and gray matter volumes. The higher‐literacy group had greater total‐brain FA and higher temporal, parietal, and occipital FA values after multivariable adjustments.DiscussionHigher literacy is associated with higher white matter integrity as well as with better cognitive performance in middle‐aged adults. These results highlight the importance of focusing on midlife interventions to improve literacy skills.
TB500/TB1000 and SGF1000: A scientific approach for a better understanding of misbranded and adulterated drugs
Authors: Delcourt Vivian , Garcia Patrice , Chabot Benjamin , Barnabé Agnès , Bouscarel Maëlle , Loup Benoit , Popot Marie‐Agnès , Bailly‐Chouriberry Ludovic 
Published: December 2022

AbstractNowadays, numerous websites attempt to commercialize over the internet various products, regardless of the lack of approval by the EMA or the FDA either for human or veterinary use. These products are often produced after aborted drug development due to insufficient or deleterious biological effects, synthesized based on natural products, or only based on scientific literature. However, the administration of such products is dangerous, considering the lack of official control over the production of these substances and the absence of approval by health authorities. In this short communication, we provide an extensive analysis of three misbranded and adulterated products sold over the internet named TB500, TB1000, and SGF1000. We confirm that the content of TB500/TB1000 products is not systematically consistent with it's former descriptions, but also that SGF1000 is mainly composed of sheep extracellular matrix (ECM) and blood proteins, and the signal corresponding to the purported growth promoters is excessively diluted.
Counting the Capital's cats: Estimating drivers of abundance of free‐roaming cats with a novel hierarchical model
Authors: Cove Michael V. , Herrmann Valentine , Herrera Daniel J. , Augustine Ben C. , Flockhart D. T. Tyler , McShea William J. 
Published: December 2022

AbstractFree‐roaming cats are a conservation concern in many areas but identifying their impacts and developing mitigation strategies requires a robust understanding of their distribution and density patterns. Urban and residential areas may be especially relevant in this process because free‐roaming cats are abundant in these anthropogenic landscapes. Here, we estimate the occupancy and density of free‐roaming cats in Washington D.C. and relate these metrics to known landscape and social factors. We conducted an extended camera trap survey of public and private spaces across D.C. and analyzed data collected from 1483 camera deployments from 2018 to 2020. We estimated citywide cat distribution by fitting hierarchical occupancy models and further estimated cat abundance using a novel random thinning spatial capture‐recapture model that allows for the use of photos that can and cannot be identified to individual. Within this model, we utilized individual covariates that provided identity exclusions between photos of unidentifiable cats with inconsistent coat patterns, thus increasing the precision of abundance estimates. This combined model also allowed for unbiased estimation of density when animals cannot be identified to individual at the same rate as for free‐roaming cats whose identifiability depended on their coat characteristics. Cat occupancy and abundance declined with increasing distance from residential areas, an effect that was more pronounced in wealthier neighborhoods. There was noteworthy absence of cats detected in larger public spaces and forests. Realized densities ranged from 0.02 to 1.75 cats/ha in sampled areas, resulting in a district‐wide estimate of ~7296 free‐roaming cats. Ninety percent of cat detections lacked collars and nearly 35% of known individuals were ear‐tipped, indicative of district Trap‐Neuter‐Return (TNR) programs. These results suggest that we mainly sampled and estimated the unowned cat subpopulation, such that indoor/outdoor housecats were not well represented. The precise estimation of cat population densities is difficult due to the varied behavior of subpopulations within free‐roaming cat populations (housecats, stray and feral cats), but our methods provide a first step in establishing citywide baselines to inform data‐driven management plans for free‐roaming cats in urban environments.
Implementing community‐engaged ecological research in Proctor Creek, an urban watershed in Atlanta, Georgia, USA
Authors: Johnson Tamara , Jelks Na'Taki Osborne 
Published: December 2022

AbstractThe Southeast Region of the United States Fish and Wildlife Service (USFWS) implemented community‐engaged research in Proctor Creek, an urban watershed in Northwest Atlanta, Georgia, to sample for aquatic species of concern in Atlanta, Georgia's Proctor Creek Watershed as a part of the Urban Waters Federal Partnership program. This research shifted the focus of the agency from the endangered and pristine natural spaces to a major city watershed negatively impacted by urbanization and other human influences for more than a century. Team members from USFWS, Proctor Creek Watershed residents, local students, and other stakeholders in the Urban Waters Federal Partnership (UWFP) spent three months conducting stream surveys and participating in community‐led events to build relationships and learn community priorities. The team collected data at 11 sites throughout the Proctor Creek Watershed, visually assessed each site, and collected aquatic species using dip nets, seines, and traps. We observed approximately 28 aquatic species, including 13 unique fish species, and eight macroinvertebrate species, including two unique crayfish species. We also observed varying degrees of ecological health throughout the watershed. Native aquatic animal species were found at all stream sites, no matter the condition of the stream. Through creating training resources and disseminating data among team members for future sampling, the team established pathways to keep natural resource stewardship sustainable without direct federal involvement. Through engaging in community‐engaged research to achieve the mission of the agency, the USFWS Proctor Creek Watershed survey helped shift the paradigm of how government agencies can connect their mission statements to the ever‐changing complex needs of the American public.
Structure and molecular evolution of the barcode fragment of cytochrome oxidase I (COI) in Macrocheles (Acari: Mesostigmata: Macrochelidae)
Authors: Khakestani Najme , Latifi Malihe , Babaeian Esmaeil , Knee Wayne , Hosseini Samin 
Published: December 2022

AbstractConsisting of approximately 320 species, Macrocheles is the most widely distributed genus in the family Macrochelidae. Though some studies have focused on the description of Macrochelidae using molecular techniques (e.g., RAPD) and sequencing of some genes, the interspecies relationships within Macrocheles still remain uncertain. As such, in the present study, we examine all publicly available data in GenBank to explore the evolutionary relationships, divergence times, and amino acid variations within Macrocheles. Exploring the patterns of variation in the secondary protein structure shows high levels of conservation in the second and last helices, emphasizing their involvement in the energy metabolism function of the cytochrome oxidase subunit I enzyme. According to our phylogenetic analysis, all available Macrocheles species are clustered in a monophyletic group. However, in the reconstructed trees, we subdivided M. merdarius and M. willowae into two well‐supported intraspecific clades that are driven by geographic separation and host specificity. We also estimate the divergence time of selected species using calibration evidence from available fossils and previous studies. Thus, we estimate that the age of the Parasitiformes is 320.4 (273.3–384.3) Mya (Permian), and the Mesostigmata is 285.1 (270.8–286.4) Mya (Carboniferous), both with likely origins in the Paleozoic era. We also estimate that Macrocheles diverged from other Mesostigmata mites during the Mesozoic, approximately 222.9 Mya.