bluuebunny/crossref_metadata_2025_split huggingface dataset:
The UK Chinese population with kidney failure: Clinical characteristics, management and access to kidney transplantation using 20 years of UK Renal Registry and NHS Blood and Transplant data
Authors: Wong Katie , Caskey Fergus J. , Casula Anna , Ben-Shlomo Yoav , Bailey Pippa 
Published: February 2022

Background
Little is known about the clinical demographics of and access to transplantation for Chinese diaspora populations with kidney disease.

Methods
The UK Renal Registry provided data on adults with ethnicity recorded as ‘Chinese’ or ‘White’ starting Kidney Replacement Therapy (KRT) 1/1/97-31/12/17. Baseline characteristics were compared between Chinese and White patients. Multivariable logistic regression models were used to investigate the relationships between Chinese ethnicity and i) being listed for deceased-donor transplantation at start of KRT, ii) being listed 2 years after start of KRT, iii) pre-emptive kidney transplantation, iv) kidney transplantation 3 years after start of KRT, and v) living-donor kidney transplantation (LDKT).

Results
UK Chinese patients were younger at start of KRT (61.6 vs 65.6 years, p <0.001) and had more diabetic kidney disease (29% vs 20%, p<0.001) and glomerulonephritis (21% vs 13%, p<0.001) than White patients. We found evidence of interaction between ethnicity and sex. Compared to UK White men, UK Chinese men had lower odds of pre-emptive transplant (aOR 0.28, 95% CI [0.10–0.76]) and transplant within 3 years of KRT start (aOR 0.65, [95% CI 0.49–0.87], P = 0.004). UK White women and Chinese women had the same likelihood of pre-emptive transplant (aOR 0.78, 95% CI [0.38–1.61]), or transplant within 3 years of KRT start (aOR 0.94, 95% CI [0.60–1.46]). Both UK Chinese men and women had markedly lower odds of LDKT compared to Whites aOR 0.34 [95% CI 0.21–0.53].

Conclusions
UK Chinese are less likely to receive a LDKT. UK Chinese men have lower odds of accessing pre-emptive wait-listing and transplantation. Understanding whether these disparities reflect modifiable barriers will help ensure equitable access to transplantation.
The minipig intraoral dental implant model: A systematic review and meta-analysis
Authors: Musskopf Marta Liliana , Finger Stadler Amanda , Wikesjö Ulf ME , Susin Cristiano 
Published: February 2022

ObjectivesThe objective of this report was to provide a review of the minipig intraoral dental implant model including a meta-analysis to estimate osseointegration and crestal bone remodeling.MethodsA systematic review including PubMed and EMBASE databases through June 2021 was conducted. Two independent examiners screened titles/abstracts and selected full-text articles. Studies evaluating titanium dental implant osseointegration in native alveolar bone were included. A quality assessment of reporting was performed. Random-effects meta-analyses and meta-regressions were produced for bone-implant contact (BIC), first BIC, and crestal bone level.Results125 out of 249 full-text articles were reviewed, 55 original studies were included. Quality of reporting was generally low, omissions included animal characteristics, examiner masking/calibration, and sample size calculation. The typical minipig model protocol included surgical extraction of the mandibular premolars and first molar, 12±4 wks post-extraction healing, placement of three narrow regular length dental implants per jaw quadrant, submerged implant healing and 8 wks of osseointegration. Approximately 90% of studies reported undecalcified incandescent light microscopy histometrics. Overall, mean BIC was 59.88% (95%CI: 57.43–62.33). BIC increased significantly over time (p<0.001): 40.93 (95%CI: 34.95–46.90) at 2 wks, 58.37% (95%CI: 54.38–62.36) at 4 wks, and 66.33% (95%CI: 63.45–69.21) beyond 4 wks. Variability among studies was mainly explained by differences in observation interval post-extraction and post-implant placement, and implant surface. Heterogeneity was high for all studies (I2> 90%, p<0.001).ConclusionsThe minipig intraoral dental implant model appears to effectively demonstrate osseointegration and alveolar bone remodeling similar to that observed in humans and canine models.
COVID-19 vaccine acceptance and rejection in an adult population in Bosnia and Herzegovina
Authors: Fojnica Adnan , Osmanovic Ahmed , Đuzic Nermin , Fejzic Armin , Mekic Ensar , Gromilic Zehra , Muhovic Imer , Kurtovic-Kozaric Amina 
Published: February 2022

BackgroundBosnia and Herzegovina is among ten countries in the world with the highest mortality rate due to COVID-19. Lack of lockdown, open borders, high mortality rate, no vaccination plan, and strong domestic anti-vaccination movement present serious COVID-19 concerns in Bosnia and Herzegovina. In such circumstances, we set out to study 1) the willingness of general public to receive the vaccine, 2) factors that affect vaccine rejection, and 3) motivation for vaccine acceptance.MethodsA cross-sectional study was conducted among 10471 adults in Bosnia and Herzegovina to assess the acceptance or rejection of participants toward COVID-19 vaccination. Using a logistic regression model, we examined the associations of sociodemographic characteristics with vaccine rejection, reasons for vaccine hesitancy, preferred vaccine manufacturer, and information sources.ResultsSurprisingly, only 25.7% of respondents indicated they would like to get a COVID-19 vaccine, while 74.3% of respondents were either hesitant or completely rejected vaccination. The vaccine acceptance increased with increasing age, education, and income level. Major motivation of pro-vaccination behavior was intention to achieve collective immunity (30.1%), while the leading incentive for vaccine refusal was deficiency of clinical data (30.2%). The Pfizer-BioNTech vaccine is shown to be eightfold more preferred vaccine compared to the other manufacturers. For the first time in Bosnia, vaccine acceptance among health care professionals has been reported, where only 39.4% of healthcare professionals expressed willingness to get vaccinated.ConclusionWith the high share of the population unwilling to vaccinate, governmental impotence in securing the vaccines supplies, combined with the lack of any lockdown measures suggests that Bosnia and Herzegovina is unlikely to put COVID-19 pandemic under control in near future.
Gene deletion of γ‐actin impairs insulin‐stimulated skeletal muscle glucose uptake in growing mice but not in mature adult mice
Authors: Knudsen Jonas R. , Madsen Agnete B. , Li Zhencheng , Andersen Nicoline R. , Schjerling Peter , Jensen Thomas E. 
Published: February 2022

AbstractThe cortical cytoskeleton, consisting of the cytoplasmic actin isoforms β and/or γ‐actin, has been implicated in insulin‐stimulated GLUT4 translocation and glucose uptake in muscle and adipose cell culture. Furthermore, transgenic inhibition of multiple actin‐regulating proteins in muscle inhibits insulin‐stimulated muscle glucose uptake. The current study tested if γ‐actin was required for insulin‐stimulated glucose uptake in mouse skeletal muscle. Based on our previously reported age‐dependent phenotype in muscle‐specific β‐actin gene deletion (−/−) mice, we included cohorts of growing 8–14 weeks old and mature 18–32 weeks old muscle‐specific γ‐actin−/− mice or wild‐type littermates. In growing mice, insulin significantly increased the glucose uptake in slow‐twitch oxidative soleus and fast‐twitch glycolytic EDL muscles from wild‐type mice, but not γ‐actin−/−. In relative values, the maximal insulin‐stimulated glucose uptake was reduced by ~50% in soleus and by ~70% in EDL muscles from growing γ‐actin−/− mice compared to growing wild‐type mice. In contrast, the insulin‐stimulated glucose uptake responses in mature adult γ‐actin−/− soleus and EDL muscles were indistinguishable from the responses in wild‐type muscles. Mature adult insulin‐stimulated phosphorylations on Akt, p70S6K, and ULK1 were not significantly affected by genotype. Hence, insulin‐stimulated muscle glucose uptake shows an age‐dependent impairment in young growing but not in fully grown γ‐actin−/− mice, bearing phenotypic resemblance to β‐actin−/− mice. Overall, γ‐actin does not appear required for insulin‐stimulated muscle glucose uptake in adulthood. Furthermore, our data emphasize the need to consider the rapid growth of young mice as a potential confounder in transgenic mouse phenotyping studies.
Irisin response to acute moderate intensity exercise and high intensity interval training in youth of different obesity statuses: A randomized crossover trial
Authors: Colpitts Benjamin H. , Rioux Brittany V. , Eadie Ashley L. , Brunt Keith R. , Sénéchal Martin 
Published: February 2022

AbstractLimited data exist regarding the impact of an acute bout of exercise with varying intensities on irisin levels in the youth of different obesity statuses. The objectives were to (1) compare an acute bout of moderate continuous intensity (MCI) exercise and an acute bout of high‐intensity interval training (HIIT) on irisin response in youth with different obesity statuses and, (2) investigate whether changes in irisin levels are correlated with exploratory outcomes. A randomized crossover design study was conducted on 25 youth aged 12–18 years old. Participants were classified as either healthy weight (BMI percentile <85; n = 14) or overweight/obese (BMI percentile ≥85; n = 11). Participants performed an MCI exercise session at 50% of heart rate reserve for 35 min and a HIIT exercise session for 35 min, with intervals every 5 min increasing from 50% heart rate reserve to 85–90% for 2 min. Irisin was measured using an enzyme‐linked immunoabsorbent assay from plasma sampling obtained throughout the exercise (at times 0, 7, 14, 21, 28, and 35 min). A time effect was observed throughout the HIIT session [F(1,5) = 6.478, p < 0.001]. Bonferonni post‐hoc analysis revealed significant differences in irisin levels post‐exercise (35 min) compared to times 7, 14, 21, and 28 min. Irisin increased during HIIT (81.0% ± 71.3; p = 0.012) in youth with a healthy weight. No differences were observed for youth living as overweight or with obesity. Overall, HIIT elicits a higher peak irisin response compared to MCI exercise training in youth.
Body composition and immunonutritional status in patients treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC) for gastrointestinal peritoneal metastases: a prospective single-center analysis
Authors: Rotolo Stefano , Di Giorgio Andrea , Cintoni Marco , Rinninella Emanuele , Palombaro Marta , Pulcini Gabriele , Schena Carlo Alberto , Chiantera Vito , Vizzielli Giuseppe , Gasbarrini Antonio , Pacelli Fabio , Mele Maria Cristina 
Published: February 2022

Abstract

Objectives
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel drug administration method with promising efficacy for the treatment of peritoneal metastases (PM). This study aimed to evaluate the prognostic value of an immunonutritional assessment on the feasibility, safety, and survival in this setting.

Methods
Data of PM patients undergoing PIPAC between September 2018 and May 2020 were prospectively recorded. A CT scan-derived body composition assessment was performed for each patient.

Results
Fifty-one patients were enrolled, of which 30 (58%) underwent multiple PIPAC cycles, with a pathological response rate of 55%. Prognostic nutritional index (PNI) and neutrophil-to-lymphocytes predicted completion of more than one PIPAC cycle, with a cut off of 36.5 and 4.8 respectively. Muscle attenuation and body fat tissues were associated with pathological response. At multivariate Cox regression analysis, only the presence of a low PNI (HR 2.41, 95% CI 1.08–5.46) was significantly associated with a worse OS.

Conclusions
A pretreatment immunonutritional assessment may provide valuable information for PIPAC patients’ selection and survival, while body composition parameters are able to predict pathological response. Further larger studies are needed to validate the role of these biomarkers in tailoring the treatment and monitoring PM patients undergoing PIPAC.
The effect of hydrogen sulfide on the contractility of cerebral arterioles. A pilot study
Authors: Dongó Eleni , Harasztos Luca , Nádasy György L. , Kiss Levente 
Published: February 2022

Abstract

Background and Aims
Endogenous gaseous substances, such as NO and CO have been found to be effective vasodilators earlier. H2S has been identified as an additional one, however, for that substance both vasodilatory and vasoconstrictor responses have been described in different vascular territories. Our aim was to examine the effect of hydrogen sulfide on the tone of cerebral arterioles and some aspects of its mechanism.

Methods
The work was performed on excised rat anterior cerebral artery segments in vitro (diameter range 150–250 µm), using a pressure myograph system. We used NaHS as exogenous H2S donor, propargylglycine (PAG) to abolish the endogenous synthesis of hydrogen sulfide and 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid (DIDS) to examine the potential role of Cl−/HCO3
- exchanger in the effects of H2S. The time course of the events after application of exogenous H2S was also evaluated.

Results
Our findings revealed that in these pathologically important vessels (1) endogenously produced H2S is not a vasodilator, but a moderate vasoconstrictor; (2) H2S has a biphasic effect: low concentrations are moderate vasoconstrictors, while at higher concentrations the initial contraction is followed by dilatation; (3) that vasodilation is prevented by DIDS (4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium, an inhibitor of the Cl−/HCO3
- exchanger).

Conclusion
These studies confirm that H2S should be taken into consideration as a modulator of cerebral arteriolar tone in mammals.
Aspects of size effect on discrete element modeling of concrete
Authors: Gyurkó Zoltán , Nemes Rita 
Published: February 2022

Abstract
Present paper focuses on the modeling of size effect on the compressive strength of normal strength concrete with the application of discrete element method, considering specimen of different concrete mixes and shapes. An equation was derived to estimate the parallel bond strength from the compressive strength. The results showed a good agreement with the literature and the derived estimation models showed strong correlation with the measurements. The results indicated that size effect is stronger on concretes with lower strength class and that it is more significant on cube specimens than on cylinders. The relationship of model size and computational time was analyzed and a method to decrease the computational time (iterations) was proposed.
Improving university students’ coordinating skills in physical education lessons with basketball focus
Authors: Nae Cristina I. , Pop Cristiana L. 
Published: February 2022

Background and Study Aim. The purpose of the study was to examine the effectiveness of a 14-week intervention in improving coordination skills among female university students. The intervention consisted in physical education lessons with basketball focus, the final practical outcome being to practice a coherent and satisfying game for the players.
Material and Methods. The research was carried out on a group of 15 female university students aged 19-20, in the second semester of the academic year 2018-2019, lasted 14 weeks, with a frequency of 1 lesson per week. The applied tests were dynamic balance, body coordination, hands coordination, basketball spot shooting, wall passes. Measurements were performed before intervention as a baseline and after it to record the effect size. The manipulated variable was a physical exercises program designed in purpose to produce an effect on the dependent variable: coordination skills improvement. The significant mean difference and the effect size was statistically demonstrated with student t-test p <0.005.
Results. From the statistical data obtained, we found that the results of ‘before and after’ tests differ significantly. For all the parameters under discussion the effect magnitude was large and mostly very large, also the research hypothesis was accepted.
Conclusions. Applying the designed program has led to a substantial improvement of coordinating skills and has positively influenced the effectiveness of the basketball technique learning process.
The effect of ankle strengthening exercise on balance in youth basketball players
Authors: Nugraha Pratama D. , Soegiyanto Soegiyanto , Kristiyanto Agus , Azam Mahalul 
Published: February 2022

Background and Study Aim. Balance is an important factor in basketball. Thus, the low level of balance needs to be improved to support future achievements of youth basketball players. The aim of study is to determine the influence of bosu ball exercises and theraband exercise on the balance of basketball players aged 16 and 18 years old.
Material and Methods. The research design used is experimental research with 2x2 factorial analysis.
The level of significance was set a 0.05 for all samples. In the study participated 64 men's basketball players aged 16 years old (n=32) and 18 years old (n=32). Players were each divided into 4 sample groups of 8 players.
Results. The test results before the experiment and after the experiment showed that in all groups there were various changes in the balance. There is a more significant change in balance after performing exercises with the ball bosu in the group of 16 years old. In the 18-year-old group, there is a more significant change in balance after performing theraband exercises.
Conclusions. Characteristics of the age group of 16 years and 18 years are not much different. Bosu ball exercises give a better effect than theraband exercise.
The effect of 8-week plyometric training on jump height, agility, speed and asymmetry
Authors: Kosova Sercin , Beyhan Rüya , Koca Kosova Merve 
Published: February 2022

Background and Study Aim. Plyometric training is one of the most preferred methods for athletic performance improvement. This study was designed to measure the effect of 8 weeks of additional plyometric training on jump performance, lower extremity asymmetry, speed, and agility performances of adolescent fencers.
Material and Methods. This study was carried out with 26 fencers who participated in national competitions. The fencers were randomly divided into plyometric training (PLY, n = 14) and the control (n = 12) group. The PLY group did plyometric training 3 days per week for 8 weeks in addition to their fencing training. The control group only continued their fencing training. All participants performed countermovement jumps (CMJ), pro-agility, 0-5-m, 5-15–m, 0-15-m sprints, and asymmetry tests before and after 8 weeks.
Results. Statistically significant differences were found in CMJ, (p = 0.001), pro-agility (p = 0.001), and 0-5-m (p = 0.036), 5-15-m (p = 0.018), and 0-15-m (p = 0.001) sprint results in the PLY group. However, asymmetry contact time and asymmetry flight time values did not show statistical differences. In addition, group x time interactions of CMJ (p < 0.001), pro-agility (p = 0.001), and 0-5-m (p = 0.015) and 5-15-m (p = 0.009) sprint tests were also found statistically significant.
Conclusions. Thus, it can be said that plyometric training contributes positively to the jumping, agility, and speed of fencers. Adolescent fencers and their trainers may be advised to focus on additional plyometric training programs. However, individual differences and training experience should also be taken into account in the determination of plyometric programs.
Comparing the gross motor performance levels of 7–10 age group children with autism spectrum disorder and typical developing
Authors: Aksay Ebubekir 
Published: February 2022

Background and Study Aim. The children and adolescents with Autism Spectrum Disorder lead a sedentary lifestyle and, as a result, they are more affected by health problems such as being overweight and obese. They are physically less active than their peers showing typical developing. The aim of the study is to carry out a general comparison of the gross motor performance levels of elementary school-age children living in Germany diagnosed with autism spectrum disorder and children showing typical developing.
Material and Methods. A total of 68 children diagnosed with autism spectrum disorder and 73 children showing normal development between the ages 7 and 10 participated in the study. Of the participants, 55 were diagnosed with autism spectrum disorder were boys and 13 were girls, and the average age of the boys was 8.40±1.09 years, while the average age of the girls was 8.85±1.14 years. Of the 73 participants, 36 showing typical development consisted of boys and 37 of them consisted of girl students, and the average age of the boys was 8.56±1.08 years while the average age of the girls was 8.43±1.21 years. The Body Coordination Test for Children was used to evaluate gross motor performance components in the study.
Results. The results of the study showed that girls had lower general body coordination than boys on average. It was concluded that children who had an autism spectrum disorder diagnosis displayed statistically lower total motor performance in all of the administered tests compared to their peers showing normal development (p<0.05).
Conclusion. It is considered that the data obtained will provide important clues about the motor coordination values and body composition of children with autism spectrum disorder and will contribute to taking precautions against the health risks of children with autism spectrum disorder, who are more affected by a sedentary lifestyle compared to their normally developing peers.
Moyamoya disease: a case report of hemorrhagic stroke
Authors: Novikova L. B. , Akopyan A. P. , Sharapova K. M. , Latypova R. F. , Novikov A. I. 
Published: February 2022

This case report describes a patient with a rare cerebrovascular pathology — Moyamoya disease. The disease was manifested by acute hemorrhagic stroke.
Reverse remodeling against the background of cardiac contractility modulation therapy in patients with heart failure and atrial fibrillation
Authors: Safiullina A. A. , Uskach T. M. , Dobrovolskaya S. V. , Saidova M. A. , Makeev M. I. , Tereshchenko S. N. 
Published: February 2022

Aim. To study myocardial remodeling in patients with heart failure (HF) with reduced ejection fraction (HFrEF) and atrial fibrillation (AF) against the background of cardiac contractility modulation (CCM) therapy.Material and methods. In a group of 100 patients with HFrEF and AF, transthoracic echocardiography was performed before CCM device implantation and after 2, 6 and 12 months. All patients received longterm optimal medical therapy for HF before surgery.Results. Against the background of CCM therapy, there was a significant increase in left ventricular (LV) ejection fraction, a decrease in LV volume and linear dimensions, a decrease in left atrial volume in patients with coronary and non-coronary HFrEF, with an initial LVEF < and >35%, and also regardless of AF type.Conclusion. CCM therapy in patients with HFrEF and AF led to favorable myocardial remodeling changes. Further study of CCM effect on echocardiographic parameters in randomized clinical trials is needed.