bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Ekspor, Nilai Tukar Rupiah, dan Penanaman Modal Asing Terhadap Cadangan Devisa Indonesia Tahun 2004-2018
Authors: Ramadhanty Nadya , Syafrudin Ruddy 
Published: March 2022

The purpose of the study was to determine (1) the effect of exports, the exchange rate of the rupiah, and foreign investment on foreign exchange reserves (2) to determine which variable was the most dominant influence on foreign exchange reserves. Research conducted using multiple linear regression analysis tools, the classic assumption test, stationarity test, f test, t-test, and the coefficient of determination test. The data that has been obtained were analyzed using the E-views version 9 application for processing. The scope of this research is in Indonesia. Data sources in secondary data were obtained from documentation from relevant agencies related to this study. So it does not require questionnaires or interviews for completeness of data. The variables in this study initially used four (4) independent variables, namely exports, imports, the rupiah exchange rate, and foreign investment, but when testing the assumption constrained by multicollinearity problems until finally this study only used three (3) variables, namely exports, exchange rates, and foreign investment so that the results of the tests are in harmony. The regression analysis results in this study show that the partial export test has a significant effect and the rupiah exchange rate and foreign investment are not significant. The classic assumption test on normality shows that residuals are normally distributed; in multicollinearity, all variables have no multicollinearity problem, in heteroscedasticity, there is no heteroscedasticity problem, and in autocorrelation, there is no autocorrelation problem. The stationary test shows that all variables are integrated stationary at the second level of differentiation. A simultaneous test of export variables, rupiah exchange rate, and foreign investment simultaneously or together find the results that all significantly affect foreign exchange reserve variables. The most dominant variable influences the foreign exchange reserve variable, namely the export variable
Pengaruh Pengaruh Jumlah Tanggungan, Pendapatan, dan Pendidikan terhadap Konsumsi Rumah Tangga Masyarakat Kampung KB ( Studi Kasus: Desa Banua Batung Kecamatan Pandawan Kabupaten Hulu Sungai Tengah)
Authors: Amini Ida , Rusdiansyah Rusdiansyah 
Published: March 2022

The Effect of Amount of Dependents, Income, and Education on Household Consumption of KB Kampung Communities (Case Study: Banua Batung Village, Padawan Sub-district, Hulu Sungai Tengah District. This study was conducted to (1) analyze the effect of dependents, income, and education on household consumption KB village (family planning), (2) to find out which factors are the most dominant influencing household consumption in the KB community (family planning). The scope of this research is to take a case study in Banua Batung village, Padawan District, Hulu Sungai Tengah Regency. Data obtained from interviews and questionnaires as data from the respondent's polymer totaling 82 people. The data is processed using the help of reviews-9 software with multiple linear regression analysis, which is then tested through the f test (simultaneously) and t-test (partially). The results showed that the number of dependents, income, and education had a significant and positive effect both individually (partially) and together (simultaneously). At the same time, the most dominant factor affecting household consumption in this KB village community was income. Suggestions that should be made to increase income are by developing plantations during the rice farming pause so that land is still used, to emphasize the number of dependents, the government must continue to promote family planning programs, and while to improve education, the government is expected to make various scholarship programs so that rural children this is motivated for school.
Pengaruh Modal, Tenaga Kerja, dan Bahan Baku terhadap Hasil Produksi Industri Pengolahan Kayu di Kelurahan Alalak Selatan dan Kelurahan Alalak Tengah Kecamatan Banjarmasin Utara
Authors: Hafie Ahmad , Yunani Ahmad 
Published: March 2022

The purposes of this research are (1) to know how the finances, worker, and raw material influence the wood processing industry; (2) to know which most dominant factor influences the wood processing industry in Banjarmasin City. This Research uses quantitative method with primer data obtains from the result of interview and questionnaire. The data are calculated using double linier analysis which will be use test f (simultaneous) and test t (partial).The result of the Research shows that the factors of the finances worker, and raw material influences significantly and positively to the wood processing industry simultaneously and partially. Workers becomes the most dominant factor influencing the output of the wood processing industry.The suggestions given based on the results of the analysis and discussion in this study (1) The owner of a wood processing industry business should be able to pay attention to several factors that can affect production results in order to increase production output; (2) Increase the demand for wood by means of good promotion and marketing by utilizing increasingly developing technology.
Dampak Kebakaran Lahan Gambut terhadap Perekonomian Masyarakat di Kecamatan Gambut Kabupaten Banjar
Authors: Rosyida R , Sopiana Yunita 
Published: March 2022

This research was conducted to find out: (1) to find out how the impact of land fires on the economy of the community in the Gambut District of Banjar Regency before the occurrence of land fires (2) to find out how the impact of the land fires on the economy of the community in the Gambut District of Banjar Regency after the land fires. The respondents of this study were 87 community heads of households residing in Gambut Village, Banjar Regency. This research is a qualitative descriptive study. Data collection methods used were interviews (in-depth interviews and questionnaires), observation, documentation, and literature study. The results of this study indicate that the impact of land fires greatly influences the economy of the community in Gambut District, Banjar Regency. Land area (X1), income (X6) and occupation (X7) variables are the most dominant influences on the community's economy in the Gambut District, Banjar Regency.
Obesity Accelerates Age Defects in Human B Cells and Induces Autoimmunity +
Authors: Frasca Daniela 
Published: March 2022

Abstract
Aging is associated with systemic inflammation and decreased production of protective antibodies while the production of autoimmune antibodies is increased. Our results have shown that the human obese adipose tissue (AT), which increases in size with aging, contributes to systemic and B cell intrinsic inflammation, reduced protective and increased pathogenic B cell responses leading to increased secretion of autoimmune antibodies.
With this R56 funding, we have been able to investigate the cellular and molecular mechanisms by which the human obese AT induces intrinsic B cell inflammation and dysfunctional B cell responses, stimulates the secretion of autoimmune antibodies, whose specificity has been characterized, and engages different AT cell types in antigen presentation pathways to allow secretion of these autoimmune antibodies. Briefly, immune cells are recruited to the AT by chemokines released by both non-immune (adipocytes) and by resident and infiltrating immune cells. We have identified several mechanisms responsible for the release of "self" antigens, and we have shown that reduced oxygen availability and hypoxia, cell cytotoxicity and DNA damage induce cell death and lead to further release of pro-inflammatory cytokines, "self" protein antigens, cell-free DNA and lipids. We have also identified different antigen presenting cells in the AT, responsible for the activation of pathogenic B cells, class switch and secretion of autoimmune IgG antibodies. The experiments performed have allowed the discovery of novel mechanisms for pathogenic responses and the identification of pathways to target in order to promote better humoral immunity during aging.
Multi-ethnic Investigation of Risk and Immune Determinants of COVID-19 Outcomes
Authors: Jun Tomi , Mathew Divij , Sharma Navya , Nirenberg Sharon , Huang Hsin-Hui , Kovatch Patricia , Wherry E John , Huang Kuan-lin 
Published: March 2022

Abstract
Background: Disparate COVID-19 outcomes have been observed between Hispanic, Non-Hispanic Black, and White patients. The underlying causes for these disparities are not fully understood. Methods: This was a retrospective study utilizing electronic medical record data from five hospitals within a single academic health system based in New York City. Multivariable logistic regression models were used to identify demographic, clinical, and lab values associated with in-hospital mortality. Results: 3,086 adult patients with self-reported race/ethnicity information presenting to the emergency department and hospitalized with COVID-19 up to April 13, 2020 were included in this study. While older age (multivariable OR 1.06, 95% CI 1.05-1.07) and baseline hypoxia (multivariable OR 2.71, 95% CI 2.17-3.36) were associated with increased mortality overall and across all races/ethnicities, Non-Hispanic Black (median age 67, IQR 58-76) and Hispanic (median age 63, IQR 50-74) patients were younger and had different comorbidity profiles compared to Non-Hispanic White patients (median age 73, IQR 62-84; p<0.05 for both comparisons). Among inflammatory markers associated with COVID-19 mortality, there was a significant interaction between the Non-Hispanic Black population and interleukin-1-beta (interaction p-value 0.04). Conclusions: This analysis of a multi-ethnic cohort highlights the need for inclusion and consideration of diverse popualtions in ongoing COVID-19 trials targeting inflammatory cytokines.
Geomorphic Signatures and Reconstruction of the Surface Deformation in Highly Undulating Mountainous Areas: A Case Analysis of A Small Watershed on the Jinsha River, China
Authors: Gu Zhenkui 
Published: March 2022

Abstract
Monitoring the deformation phenomenon in high undulating mountainous areas links surface process research and geological disaster prevention. InSAR-based observation is an effective method, but layerover phenomena easily restrict its application. Based on a series of geomorphic parameters and limited observation results of InSAR technology, this paper attempts to reconstruct surface deformations in the missing observation area by constructing a random forest model to compensate for the layerover problem at the grid scale. The results show that it is a feasible scheme to reconstruct the characteristics of terrain variation in the missing observation area through geomorphic parameters, and the larger the angle between radar observation direction and dominant slope direction of the observation area, the greater the correlation between the reconstructed topography deformation characteristics and the actual observed results. In addition, before the model building of geomorphic parameter selection, elevation variation, hypsometric integral value, slope form, lithology, slope variation, and aspect variation can be considered to affect the surface deformation greatly, which are closely related to the spatial autocorrelation of these parameters. These understandings are of great significance for eliminating the layerover problem that often occurred in alpine canyon regions in InSAR observation and for further identifying disaster areas.
Description of Prasinibacter corallicola gen. nov., sp. nov., a zeaxanthin-producing bacterium isolated from stony coral Porites lutea
Authors: Yu Kefu , Wang Guanghua , Liu Jianfeng , Li Yuanjin , Li Jin , Luo Jixin , Chen Biao , Liao Zhiheng , Su Hongfei , Liang Jiayuan 
Published: March 2022

Abstract
Thermal stress is considered one of the main causes of mass scleractinian coral degradation; however, it is still unknown how corals can adapt to future global warming. In this study, ten genera of coral-associated flavobacteria were shown to produce zeaxanthin, a carotenoid antioxidant, which may help coral holobionts to alleviate thermal stress. In addition, a novel zeaxanthin-producing flavobacterium, designated R38T, was identified using polyphasic taxonomy. Although strain R38T shared a maximum 16S rRNA gene sequence similarity of 93% with Mesoflavibacter aestuarii KYW614T, phylogenetic analyses based on whole genome and 16S rRNA gene sequences revealed that strain R38T forms a distinct branch in a robust cluster composed of strain R38T and Leptobacterium flavescens KCTC 22160T under the family Flavobacteriaceae. Strain R38T exhibited average nucleotide identities of 70.2% and 72.5% for M. aestuarii KYW614T and L. flavescens KCTC 22160T, respectively. The only detected respiratory quinone was menaquinone 6 (MK-6). The genomic DNA G + C content was 33.2 mol%. The major polar lipids were phosphatidylmethylethanolamine, phosphatidylethanolamine, one unidentified ninhydrin phospholipid, three unidentified ninhydrin-positive lipids, and three unidentified lipids. The major cellular fatty acids were iso-C15 : 0, iso-C15 : 0ω6c, C16:2 DMA, and C13:1ω3c. The distinct biochemical, chemotaxonomic, phylogenetic, and phylogenomic differences from validly published taxa suggest that strain R38T represents a new species of a new genus, for which Prasinibacter corallicola gen. nov., sp. nov. is proposed. The type strain R38T (= MCCC 1K03889T = KCTC 72444T).
Ascending Aortic Wall Degeneration in Patients with Bicuspid Versus Tricuspid Aortic Valve
Authors: Mennander Ari , Kholova Ivana , Pelttari Saku , Paavonen Timo 
Published: March 2022

Abstract
Background
The magnitude of ascending aortic degeneration in patients with bicuspid aortic valves (BAV) is controversial.
Methods
The aim of this study was to investigate ascending aortic wall degeneration in patients with BAV as compared with tricuspid aortic valves (TAV). The ascending aortic wall of 67 consecutive patients was processed for histology and immunohistochemistry. The extent of surgery and wall degeneration were investigated. Unadjusted survival was evaluated by Kaplan-Meier analysis. Median follow-up for patients with BAV and TAV was 3.8 years (interquartile range [IQR] 3.5-4.1) and 3.7 years (IQR 3.4-3.9), respectively.
Results
There were 33 patients with BAV and 34 with TAV. Mid-ascending aorta diameter was 54 mm (IQR 50-60). Replacement of the aortic valve, together with an ascending aortic prosthesis, was more frequent in BAV vs TAV patients (24% vs 3%, P = 0.013). However, medial fibrosis, elastic fiber thinning, incremental medial degeneration and smooth muscle cell nuclei loss were less prominent in BAV vs TAV patients (0.1 ± 0.4 vs 0.8 ± 1.4, P = 0.016; 0.6 ± 1.4 vs 1.6 ± 2.0, P = 0.027; 1.7 ± 0.7 vs 2.2 ± 0.8, P = 0.045 and 2.3 ± 1.5 vs 3.2 ± 1.3, P = 0.026, respectively).
Conclusions
Since degeneration of the ascending aortic wall was seldom prominent, histopathology alone does not support the need for earlier surgery of the dilated ascending aorta in BAV patients as compared with TAV patients.
LRP6 modulates the phosphorylation of Cx43 via Gαs in ventricular tachycardia of myocardial infarction
Authors: Zhang Xuming , Liu Ya-ling , Cai Ying , Hao Ying , Kang Sheng 
Published: March 2022

Abstract
Background Ventricular tachycardia (VT) and ventricular fibrillation are the most causes of early death in patients with myocardial infarction (MI). This study was aimed to explore whether LRP6 and its upstream genes circRNA1615 and miR-152-3p modulated the phosphorylation of Connexin-43 (Cx43) via Gαs in ventricular tachycardia of MI.Method we constructed the hypoxia cardiomyocyte model and AMI mice, and explored the modulation relationship of LRP6 and its upstream genes circRNA1615 and miR-152-3p. In addition, the immunoblot analysis with monoclonal and polyclonal antibodies were used to detect whether LRP6 and Cx43 were phosphorylated, further investigated that the LRP6 regulated the phosphorylation of its downstream target Cx43 via G-protein alpha subunit Gαs by using cell transfection, FISH assay, HE staining, RT-qPCR, and Western blot techniques.Result LRP6 mRNA expression was significantly reduced in AMI group compared with the control group. Hypoxia could inhibit the protein and phosphorylation levels of LRP6 and Cx43. The expression of circRNA1615 in AMI mice was significantly decreased, but overexpression of circRNA1615 significantly reversed the inhibitory effect of AMI. Also overexpression of circRNA1615 could weaken the effect of miR-152-3p mimic, and the miR-152-3p mimic increased the hypoxia injury of LRP6 and Cx43, further LRP6 interference fragments could aggravate hypoxia injury of Cx43. The overexpression of LRP6 could significantly increase the protein level and phosphorylation level of Cx43, but the interference with LRP6 showed the opposite trend. Noticeably, the interference with Gαs weakened the protein and phosphorylation levels of Cx43, however, the interference with LRP6 further inhibited the protein and phosphorylation levels of Cx43. Finally, the transcriptions of circRNA1615 and LRP6 were inhibited in AMI, but the transcription of miR-152-3p was promoted, and the overexpression of circRNA1615 could weaken the damage effect and VT of AMI.Conclusion LRP6 and its upstream genes circRNA1615 and miR-152-3p modulated the phosphorylation of Cx43 via Gαs in ventricular tachycardia of myocardial infarction.
The Prevention of Rectovaginal Fistula After Rectal Cancer Surgery by Packing With Laparoscopic Dislocated Fat Flap Containing Ovarian Vascular Pedicle Anterior to the Anastomotic Stoma
Authors: Ye Dao-xiong , Huang Sheng-hui , Lin Yu , Huang Ying , Pan Chi 
Published: March 2022

Abstract
Background: Rectovaginal fistula (RVF) is an abnormal channel formed by epithelial tissue between the anterior wall of rectum and the posterior wall of vagina, which is manifested as vaginal gassing and defecation. It is one of the common complications of female pelvic surgeries. With the increase of proctectomy for rectal cancer, the number of postoperative rectovaginal fistulas also increases. Once RVF occurs, although there are various treatments available, the failure rate is high [1]. RVF causes great suffer to women and is still a major problem in practice. Therefore, it is significant for female rectal cancer patients to prevent RVF after rectal cancer surgery and reduce its incidence. In this study, we introduce a new approach to prevent RVF during rectal cancer radical operation.Methods: In this two-arm randomized controlled trial, all operations were performed according to the principle of TME radical resection in rectal cancer surgery. Experimental group:The anterior rectal wall of about 1 cm distal to the anastomosis was dislocated. Before the anastomosis of the rectal end, a fat flap (usually left side) containing ovarian vascular pedicle was dislocated, measured by 10-15 cm in length and 2 cm in width. The fat flap containing ovarian vascular pedicle was packed and fixed anterior to the anastomotic stoma with fibrin glue.Control group :All operations were performed according to the principle of TME radical resection in rectal cancer surgery. Participants will be compared on several variables, including Incidence of rectovaginal fistula after operation(primary outcomes),the occurrence time of postoperative rectovaginal fistula,the occurrence time of rectovaginal fistula after stoma closure and other postoperative complications, such as anastomotic leakage, chylous leakage, intestinal obstruction, etc(secondary outcomes).Data collection will take place baseline , within one weeks post treatment and at 14-month follow-up .Determine that whether there was a statistical difference in the incidence of rectovaginal leakage between the experimental group and the control group.Discuss the feasibility of this method for the prevention of postoperative rectovaginal fistula.Discussion: It is easy and effective to prevent RVF after rectal cancer surgery by packing with laparoscopic dislocated fat flap containing ovarian vascular pedicle anterior to the anastomotic stoma.Trial registration: Chinese Clinical Trial Registry(ChiCTR)Rregistration ID: ChiCTR20003144.Registered on June 26, 2019.
Effectiveness of Nootropics in Combination with Cholinesterase Inhibitors on Cognitive Function in Mild-to-Moderate Dementia: A Study Using Real-world Data
Authors: Kang Minjae , Lee Dan Bee , Kwon Sungchan , Lee Eun , Kim Woo Jung 
Published: March 2022

Abstract
BackgroundThe clinical benefits of nootropics in the treatment of cognitive decline has been either limited or controversial. This study aimed to observe the effectiveness of cholinesterase inhibitor (ChEI) and nootropics combination in the treatment of cognitive impairment in dementia. MethodsData were based on electronic medical records in a university health system. Patients with mild-to-moderate dementia and no history of prior cognitive enhancer use were included (n = 583). The subjects were categorized into the ChEI only group and the ChEI and nootropics combination group. The primary outcome measure was the change in cognitive function, as assessed by the mini-mental state examination (MMSE) from baseline to 300–400 days after the first ChEI prescription. Subsequent analyses were conducted in consideration of the dementia type, medical adherence, and type of nootropics. ResultsThe changes in MMSE scores from baseline to endpoint were not significantly different between the two groups. In Alzheimer’s dementia, the combination group showed significantly less deterioration in MMSE language subscale scores compared to the ChEI only group (F = 6.86, p = 0.009), and the difference was consistent in the highly adherent subjects (F = 10.16, p = 0.002). The choline alfoscerate and the ginkgo biloba extract subgroups in Alzheimer’s dementia showed more significant improvements in the MMSE language subscale scores compared to the other nootropics subgroup (F = 7.04, p = 0.001). ConclusionsThe present study showed that the effectiveness of ChEI and nootropics combination on cognition may appear differently according to the dementia type. It emphasizes the need for well-controlled studies to generalize the effectiveness of nootropics across various clinical settings.
Rolling e-learning courses on COVID-19: an Italian experience
Authors: Fabrizio Pregliasco , Rosa Valetto Maria , Filippo Anelli , Andrea Mandelli , Nicoletta Scarpa , Pietro Dri 
Published: March 2022

Abstract
Background We report the results of an e-learning project focused on the progressively acquired knowledge on Coronavirus Disease 19 (COVID-19), targeted to Italian healthcare professionals. and funded by the Italian National Federation of the Associations of Doctors, Surgeons and Dentists (FNOMCeO) and the Federation of Orders of Italian Pharmacists (FOFI). Methods The core course was launched as soon as the first cases of COVID-19 occurred in Italy. Several courses have been published throughout 2020 to meet the pandemic-related educational needs and offer continuously updated and evidence-based contents, supported by evidence-based scientific information and institutional sources. Results From February 22nd to December 31st, 2020, 70,825 health professionals enrolled in the main course and 67,103 (94.7%) passed, obtaining the Continuing Medical Education (CME) credits. The participants accounted for approximately 19% and 12% of all Italian practising physicians/dentists and pharmacists, respectively. Over 99.5% of participants considered the contents of high quality, relevant and appropriate for their immediate educational needs. Conclusion The Italian e-learning offer developed in the first nine months of the pandemic achieved wide dissemination and excellent acceptance by healthcare professionals working in the field. This educational model provides healthcare professionals with evidence-based and tailored information. During pandemics it offers several advantages: time flexibility, remote participation, continuous updating following the emerging evidence.