bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal immune activation accelerates puberty initiation and alters mechanical allodynia in male and female C57BL6/J mice
Authors: Zhao Xin , Erickson Mary , Mohammed Ruqayah , Kentner Amanda C. 
Published: April 2022

AbstractThe mechanisms that link maternal immune activation (MIA) with the onset of neurodevelopmental disorders remain largely unclear. Accelerated puberty is also associated with a heightened risk for psychopathology in later life, but there is a dearth of evidence on the impacts of maternal infection on pubertal timing. We examined the effects of MIA on reproductive development, mechanical allodynia, and sensorimotor gating in juvenile, adolescent, and adult male and female mice. Moreover, we investigated hypothalamic neural markers associated with the reproductive and stress axes. Finally, we tested the mitigating effects of environmental enrichment (EE), which has clinical relevancy in human rehabilitation settings. Our results show that administration of polyinosinic–polycytidylic acid (poly(I:C)) on gestational day 12.5 led to early preputial separation, vaginal openings, and age of first estrus in offspring. MIA exposure altered pain sensitivity across development and modestly altered prepulse inhibition. The downregulation of Nr3c1 and Oprk mRNA in the hypothalamus of juvenile mice suggests that MIA's effects may be mediated through disruption of hypothalamic–pituitary–adrenal axis activity. In contrast, life‐long housing with EE rescued many of these MIA‐induced consequences. Overall, our findings suggest that accelerated puberty may be associated with the deleterious effects of infection during pregnancy and the onset of psychopathology.
Phyllachora species infecting maize and other grass species in the Americas represents a complex of closely related species
Authors: Broders Kirk , Iriarte‐Broders Gloria , Bergstrom Gary C. , Byamukama Emmanuel , Chilvers Martin , Cruz Christian , Dalla‐Lana Felipe , Duray Zachary , Malvick Dean , Mueller Daren , Paul Pierce , Plewa Diane , Raid Richard , Robertson Alison E. , Salgado‐Salazar Catalina , Smith Damon , Telenko Darcy , VanEtten Katherine , Kleczewski Nathan M. 
Published: April 2022

AbstractThe genus Phyllachora contains numerous obligate fungal parasites that produce raised, melanized structures called stromata on their plant hosts referred to as tar spot. Members of this genus are known to infect many grass species but generally do not cause significant damage or defoliation, with the exception of P. maydis which has emerged as an important pathogen of maize throughout the Americas, but the origin of this pathogen remains unknown. To date, species designations for Phyllachora have been based on host associations and morphology, and most species are assumed to be host specific. We assessed the sequence diversity of 186 single stroma isolates collected from 16 hosts representing 15 countries. Samples included both herbarium and contemporary strains that covered a temporal range from 1905 to 2019. These 186 isolates were grouped into five distinct species with strong bootstrap support. We found three closely related, but genetically distinct groups of Phyllachora are capable of infecting maize in the United States, we refer to these as the P. maydis species complex. Based on herbarium specimens, we hypothesize that these three groups in the P. maydis species complex originated from Central America, Mexico, and the Caribbean. Although two of these groups were only found on maize, the third and largest group contained contemporary strains found on maize and other grass hosts, as well as herbarium specimens from maize and other grasses that include 10 species of Phyllachora. The herbarium specimens were previously identified based on morphology and host association. This work represents the first attempt at molecular characterization of Phyllachora species infecting grass hosts and indicates some Phyllachora species can infect a broad range of host species and there may be significant synonymy in the Phyllachora genus.
Finding love in a hopeless place: A global database of misdirected amplexus in anurans
Authors: Serrano Filipe C. , Díaz‐Ricaurte Juan C. , Martins Marcio 
Published: April 2022

AbstractAmphibians are one of the most species‐rich vertebrate taxa, with diverse and complex reproductive behaviors. Even though mate recognition plays a vital role in reproductive success, unusual amplexus with non‐suitable mates (misdirected amplexus) have been reported to occur in the wild. Misdirected amplexus may decrease fitness, thus likely having ecological and evolutionary consequences and their frequency might increase with human‐induced changes in habitat. However, it is still unclear what promotes this unusual behavior and how widespread it is at spatial and phylogenetic scales. To fill this gap, we compiled a global database of misdirected amplexus events from literature and personal observations, with detailed information on environmental, geographical, and behavioral aspects of reported events. Furthermore, we discuss its spatial, temporal, and phylogenetic patterns. We provide a data set of 378 misdirected amplexus events for 156 amplectant species distributed across 69 genera and 18 families distributed in 52 countries in all continents except Antarctica. We collected data published or collected during the last 100 years, from 1920 to 2020, with information on the hour, month, and year of the misdirected amplexus events. We recorded a total of 282 interspecific amplexus, 46 necrophiliac amplexus, and 50 amplexus with objects or non‐amphibian species, with the United States and Brazil being the countries with the highest number of records. Misdirected amplexus did not occur equally in all zoogeographical realms, with most events occurring in the Neotropical and Nearctic realms. Interspecific amplexus was especially represented in the Neotropical and Mediterranean regions. Most events involved three species‐rich globally distributed families (Bufonidae, Ranidae, and Hylidae) but misdirected amplexus was widespread in the phylogeny. We provide a comprehensive data set of misdirected amplexus for anurans, with our results showing that it occurs extensively in the wild and across the globe. This data set provides a baseline for understanding misdirected amplexus and their spatial, temporal, and phylogenetic patterns. Likewise, this data set offers a baseline to test the environmental, ecological, and ethological drivers behind this reproductive behavior and we encourage researchers to report detailed observations of misdirected amplexus to better understand this process and its potential costs at the individual and population levels. The data are not copyright restricted; this data paper should be cited when data are used for publication, and the authors would appreciate being notified of research projects or teaching purposes when these data are used.
Synthesis and Metallation of Unsymmetric Tetrakisimidazolium Macrocycles
Authors: Rupp Stefan , Dutschke Patrick D. , Kinas Jenny , Hepp Alexander , Ekkehardt Hahn F. 
Published: April 2022

AbstractThe synthesis of the unsymmetric macrocyclic tetrakismidazolium salts H4‐4(PF6)4and H4‐5(PF6)4featuring a 2,6‐pyridinylene‐ and a 2‐bromo‐1,3‐xylylene‐bridged bisimidazolium unit is described. Reaction of macrocycle H4‐4(PF6)4with Ag2O yields the tetranuclear complex [6](PF6)4composed of four AgIions sandwiched in between two tetra‐NHC ligands. The 2,6‐pyridinylene‐bridged bisimidazolium moiety of the macrocycles can be site‐selectively deprotonated and metallated with RuIIor RhIto give the pincer complexes [8](PF6)3‐[11](PF6)3. Introduction of a second metal in these complexes by deprotonation/metallation and oxidative addition to the 2‐bromo‐1,3‐xylylene‐bridged bisimidazolium moiety of the macrocycles proved not possible.
Shear performance evaluation of PHC piles under different levels of axial load ratio
Authors: Oktiovan Yopi Prabowo , Otaki Taiga , Obara Taku , Kono Susumu , Asai Yoichi , Kobayashi Katsumi , Watanabe Hidekazu , Mukai David 
Published: April 2022

AbstractPrecast prestressed high‐strength spun concrete (PHC) piles are one of the common types of piles used in Japan due to its high bearing capacity. These piles have been utilized as an industrial standard since the 1970s as part of earthquake‐resilient foundation systems. The focus of this research is to examine the shear performance of PHC piles subjected to large earthquake loads. Three hollow‐section PHC pile specimens were tested under constant compressive or tensile axial load along with quasi‐static antisymmetric lateral load. An investigation using finite element analysis was carried out to reproduce the damage that occurred during the experiment. Comparison between experimental and analytical results were presented in terms of global and local behaviors of the piles. The finite element models were able to simulate axial splitting cracks that occurred for specimens under axial compression load. In addition, a parametric study was conducted to observe the influence of axial load ratio and shear span to diameter ratio on the shear capacity and failure mode of PHC piles. The study results along with the results from a PHC pile database are compared to the shear design equation proposed in the guidelines for PHC piles from the Architectural Institute of Japan (AIJ).
Bi‐level optimization of the integrated energy systems in the deregulated energy markets considering the prediction of uncertain parameters and price‐based demand response program
Authors: Toolabi Moghadam Ali , Soheyli Farideh , Sanei Sareh , Akbari Ehsan , Khorramdel Hossein , Ghadamyari Mojtaba 
Published: April 2022

AbstractThe proliferation of multienergy systems (MESs) in recent years has led to the higher efficiency of energy consumption in different sectors. MESs are generally studied in the context of energy hubs (EHs). Most of the previous works in the field of EH operation and scheduling are at the scale of residential households or communities. There is a research gap in proposing a framework in which the EH actively interacts with different energy networks. This article, however, is focused on the optimal operation and scheduling of the EH and two integrated energy grids such as power and heat distribution systems. The EH consists of combined heat and power (CHP), electric heat pump (EHP), thermal and electric energy storage systems, which are operated by an independent entity. The proposed optimization problem is based on the bi‐level optimization method in which the EH is the leader and two networks are the followers. Nonlinear variables are also linearized using binary expansion and Big M methods. As another research novelty, uncertainties of load demand and photovoltaic (PV) systems' output power are taken into account using a mixed machine learning (ML)‐based forecasting method. To enhance the flexibility of the system, a price‐based demand response (DR) program is proposed based on the predicted load pattern of the mixed ML method. Simulation results show the efficiency of the optimization model. Also, the DR program has a significant impact on the system's cost by 40% improvement in the profit of the system.
Review on low carbon planning and operation of integrated energy systems
Authors: Sun Dun , Liu Zeyuan , Shao Jiahao , Lin Ziqian 
Published: April 2022

AbstractThe integrated energy system is an important prerequisite for the sustainable transformation to the low‐carbon power system. Therefore, this paper aims to provide readers with insights into the existing research about the planning and operation models of integrated energy systems. First, the general structure of integrated energy systems is elaborated, and the new issues faced by the low‐carbon planning and operation for the integrated energy systems are represented. Next, the technical framework and the general model are proposed. Furthermore, the typical models and solution technologies of the low‐carbon planning and operation are summarized based on specific models operating in multiple scenarios. Finally, based on the characteristics and framework of the integrated energy system, the future research direction is given, which is expected to guide the sustainable development and low‐carbon transformation of energy systems.
Investigation of ammonium polyphosphate dilution with ground eggshells and lignin through the study of natural fibre composite flammability
Authors: Basnayake Asanka P. , Hidalgo Juan P. , Villacorta Byron , Dunn Kameron G. , Heitzmann Michael T. 
Published: April 2022

SummaryThe interactions of Calcium carbonate (e.g., eggshell powder) and Lignin with ammonium polyphosphate (APP) when used as fire retardants were investigated. Three mixing ratios ‐ 1:3, 1:1, and 3:1, were used with natural fibre reinforced composites containing a hemp mat and an epoxy matrix manufactured using a light resin transfer moulding (L‐RTM) process. The thermal decomposition of the retardant mixtures and composites was investigated using thermogravimetric analysis (TGA). The findings showed that even though the decomposition reactions of APP with eggshell powder and lignin mixtures interacted and overlapped, the same interactions could not be seen in the composites. In the composite form while the residue was affected by the retardant, the decomposition reactions were driven primarily by the hemp and epoxy. Flammability of the composites was studied by testing to 20, 35, 50, and 75 kW/m2 with a cone calorimeter, and determining the critical heat flux. While the samples with eggshell powder had higher ignition times, the critical heat flux for ignition was 13 kW/m2 for all sample groups except for a ratio of 1:3 APP to eggshell powder, which was 14 kW/m2. The lowest burning rates (mass loss and heat release) occurred in composites containing only APP, however, the addition of eggshell powder or lignin at even a ratio of 3:1 APP to either provided a notable reduction.
RoCliB– bias‐corrected CORDEX RCMdataset over Romania
Authors: Dumitrescu Alexandru , Amihaesei Vlad‐Alexandru , Cheval Sorin 
Published: April 2022

AbstractFour climate parameters (i.e. maximum, mean and minimum air temperature and precipitation amount) from 10 regional climate models, provided by the EURO‐CORDEX initiative, are adjusted using as reference the ROCADA gridded dataset. The adjustment was performed on a daily temporal resolution for the historical period (1971–2005), as well as for climate change scenarios based on two Representative Concentration Pathways (RCP4.5 and RCP8.5). The most accurately method for bias‐correction (BC) was selected following a 2‐fold cross‐validation approach, which was performed on historical data using two methods: Quantile Mapping (QMAP) and Multivariate Bias Correction with N‐dimensional probability (MBCn). The performances of the two methods are very similar when analysing the frequency distribution of each selected variable, whereas the comparison between (1) the intervariables correlation of the adjusted datasets, and (2) the reference dataset revealed much smaller differences for the dataset adjusted with the multivariate method, hence this was used for producing the BC scenario dataset. Based on the MBCn adjusted dataset, a climate change analysis over Romania was tested at the seasonal and annual scale. Overall, for the multimodel ensemble mean, at the country level, a substantial temperature increase is reported for both scenarios and no significant trend is revealed for precipitation amount. The adjusted RCMs are provided without any restrictions via an open‐access repository in netCDF CF‐1.4‐compliant file format. The BC climate models are archived at the 0.1° spatial resolution, in the WGS‐84 coordinate system, at a daily temporal resolution.
Scoping review of approaches used for remote‐access parathyroidectomy: A contemporary review of techniques, tools, pros and cons
Authors: Saito Yoshiyuki , Ikeda Yoshifumi , Takami Hiroshi , Abdelhamid Ahmed Amr H. , Nakao Atsushi , Katoh Hiroshi , Ho Keiso , Tomita Masato , Sato Michio , Tolley Neil S. , Randolph Gregory W. 
Published: April 2022

AbstractAfter our coauthors described the first remote‐access parathyroidectomy (RAP) series in 2000, several other approaches were developed. No systematic review has been performed to classify and evaluate RAP techniques. We performed a literature search using PubMed and Cochrane Library (CENTRAL). A total of 71 studies met our inclusion/exclusion criteria. RAP can be categorized into five approaches: (1) endoscopic and robotic axillary, (2) anterior chest, (3) transoral, (4) retroauricular, and (5) a combination of these approaches. The limited data in the literature suggest that the cure rates and safety of RAP are in no way inferior to those of open parathyroidectomy. Each approach has its advantages and disadvantages, and the recommendations for the selection of each approach are listed. The selection of approach methods might depend on the surgeon's experience and familiarity and the patient's preference and disease status.
Tip of the iceberg: A comprehensive review of liver disease in Inborn errors of immunity
Authors: Sharma Disha , Ben Yakov Gil , Kapuria Devika , Viana Rodriguez Gracia , Gewirtz Meital , Haddad James , Kleiner David E. , Koh Christopher , Bergerson Jenna R. E. , Freeman Alexandra F. , Heller Theo 
Published: April 2022

Abstract
Inborn errors of immunity (IEIs) consist of numerous rare, inherited defects of the immune system that affect about 500,000 people in the United States. As advancements in diagnosis through genetic testing and treatment with targeted immunotherapy and bone marrow transplant emerge, increasing numbers of patients survive into adulthood posing fresh clinical challenges. A large spectrum of hepatobiliary diseases now present in those with immunodeficiency diseases, leading to morbidity and mortality in this population. Awareness of these hepatobiliary diseases has lagged the improved management of the underlying disorders, leading to missed opportunities to improve clinical outcomes. This review article provides a detailed description of specific liver diseases occurring in various inborn errors of immunity. A generalized approach to diagnosis and management of hepatic complications is provided, and collaboration with hepatologists, immunologists, and pathologists is emphasized as a requirement for optimizing management and outcomes.
The Wheel of Well‐being: Impact of a community training programme on individual well‐being in Australia
Authors: Canning Thomas , Stewart Victoria , Harris Paul , Souraya Sally 
Published: April 2022

AbstractIssues AddressedWell‐being intervention frameworks may help improve well‐being. The Wheel of Well‐being (WoW) is designed to empower individuals to understand and use the WoW framework for themselves, their communities and in workplaces. This paper evaluates the well‐being impacts on participants of a well‐being capacity building programme using WoW, in Australia.MethodsThe programme collected quantitative data from participants at two time points, once at the beginning of the programme (Time 1) and on the final session (Time 2). Surveys assessed well‐being outcomes as well as life satisfaction, knowledge and understanding of well‐being and behavioural changes.ResultsResults of a total of 162 participants were included in this evaluation of the programme across nine cohorts. Between Time 1 and Time 2 the participants saw a small, but significant increase in well‐being scores, with no difference between age groups. The number of participants regarded as having a “High” well‐being score increased from 11% to 24%. Increases in knowledge, understanding and the implementation of actions and behaviours to improve well‐being were also observed.ConclusionThis evaluation provides evidence that participation in a short, intensive WoW programme can positively impact well‐being, behaviour and knowledge and understanding regarding well‐being. This suggests WoW may be an effective framework around which individuals can improve their well‐being.So What?Consideration should be given to the implementation of comprehensive health promotion frameworks, including WoW, to improve the well‐being of individuals. Further evaluation is needed to see if improved well‐being is maintained over longer time periods.
Efficacy and Safety of Romosozumab Among Postmenopausal Women With Osteoporosis and Mild-to-Moderate Chronic Kidney Disease
Authors: Miller Paul D , Adachi Jonathan D , Albergaria Ben-Hur , Cheung Angela M , Chines Arkadi A , Gielen Evelien , Langdahl Bente L , Miyauchi Akimitsu , Oates Mary , Reid Ian R , Santiago Norma Ruiz , Vanderkelen Mark , Wang Zhenxun , Yu Zhigang 
Published: April 2022

ABSTRACT
Patients with osteoporosis and chronic kidney disease (CKD) are at increased risk of fracture and associated negative outcomes, including increased mortality. The present post hoc analysis of two randomized, multicenter, phase 3 clinical trials—Fracture Study in Postmenopausal Women with Osteoporosis (FRAME) and Active-Controlled Fracture Study in Postmenopausal Women with Osteoporosis at High Risk (ARCH)—investigated the efficacy and safety of romosozumab in postmenopausal women with osteoporosis and mild-to-moderate CKD. The analysis included data from 7147 patients from FRAME and 4077 from ARCH. Eighty-one percent of patients from FRAME and 85% from ARCH had mild or moderate reduction in estimated glomerular filtration rate (eGFR) at baseline, and part of this reduction is likely age related. During the 1-year double-blind phases of the trials, patients received romosozumab 210 mg sc or placebo monthly in FRAME and romosozumab 210 mg sc monthly or alendronate 70 mg po weekly in ARCH. Bone mineral density (BMD) at the lumbar spine, total hip, and femoral neck and vertebral and nonvertebral fractures were assessed at baseline and month 12. In both trials, the least-square mean percent change from baseline BMD was significantly greater in the romosozumab groups versus controls across all kidney function categories at month 12. Romosozumab reduced the relative risk of new vertebral fractures at month 12 among patients with eGFR of 30–59, 60–89, and ≥90 mL/min by 72% (95% confidence interval [CI] 14–91; p = 0.017), 70% (40–85; p &lt; 0.001), and 84% (30–96; p = 0.005), respectively, in FRAME versus placebo, and by 51% (5–75; p = 0.04), 19% (−28 to 49; p = 0.39), and 57% (1–81, p = 0.04), respectively, in ARCH versus alendronate. Incidences of adverse events, asymptomatic decreases in serum calcium, and evolution of kidney function during the studies were similar across all baseline kidney function groups. Romosozumab is an effective treatment option for postmenopausal women with osteoporosis and mild-to-moderate reduction in kidney function, with a similar safety profile across different levels of kidney function. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
DDX3X alleviates doxorubicin‐induced cardiotoxicity by regulating Wnt/β‐catenin signaling pathway in an in vitro model
Authors: Feng Dandan , Li Jiang , Guo Liang , Liu Jing , Wang Shaochen , Ma Xiuyuan , Song Yunxuan , Liu Ju , Hao Enkui 
Published: April 2022

AbstractThe life‐threatening adverse effects of doxorubicin (Dox) caused by its cardiotoxic properties limit its clinical application. DDX3X has been shown to participate in a variety of physiological processes, and it acts as a regulator of Wnt/β‐catenin signaling. However, the role of DDX3X in Dox‐induced cardiotoxicity (DIC) remains unclear. In this study, we found that DDX3X expression was significantly decreased in H9c2 cardiomyocytes treated with Dox. Ddx3x knockdown and RK‐33 (DDX3X ATPase activity inhibitor) pretreatment exacerbated cardiomyocyte apoptosis and mitochondrial dysfunction induced by Dox treatment. In contrast, Ddx3x overexpression ameliorated the DIC response. Moreover, Wnt/β‐catenin signaling in cardiomyocytes treated with Dox was suppressed, but this suppression was reversed by Ddx3x overexpression. Overall, this study demonstrated that DDX3X plays a protective role in DIC by activating Wnt/β‐catenin signaling.