bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-risk Growth Trajectory Related to Childhood Overweight/Obesity and Its Predictive Model at Birth
Authors: Chen Yan , Cai Chen , Tan Jintong , Lei Xiaoping , Chen Qian , Zhang Jun , Zhang Yongjun 
Published: July 2022

Abstract

Context
Childhood obesity increases the risk of chronic disease in adulthood.

Objective
To construct an early predictive model for a growth trajectory that is highly related to childhood overweight/obesity.

Design
Prospective cohort study.

Settings
Shanghai Birth Cohort (SBC) and US Collaborative Perinatal Project (CPP).

Participants
A total of 848 mother-child pairs in the SBC (2013-2016) and 22 691 pairs in the CPP (1959-1965) with 2- and 7-year follow-up, respectively.

Main Outcome Measures
A high-risk postnatal growth trajectory intimately associated with childhood overweight/obesity and its predictive model.

Results
We demonstrated that the shifts of postnatal body mass index (BMI) percentile had been completed around 1 year of age and identified a high-risk growth trajectory that was closely related to overweight/obesity [odds ratio 6.5 (95% CI 5.9, 7.2)] at 7 years old. Children with this trajectory presented with a consistent BMI around the 85th percentile after the age of 1 year. It could be recognized early after birth using a predictive model with 4 metabolites (tyrosine, glycine, octenoylcarnitine, and stearoylcarnitine), combined with sex, birth weight, and maternal prepregnancy BMI. The model had an area under the receiver operating characteristic curve of 0.869 (95% CI 0.779, 0.932), a sensitivity of 83.3% (95% CI 51.6%, 97.9%), and a specificity of 81.1% (95% CI 70.3%, 89.3%) in the validation data set.

Conclusion
Children with postnatal high-risk growth trajectories were significantly associated with subsequent overweight/obesity at 7 years old. Metabolite profiles at birth combined with clinical measures were able to predict at-risk children before overweight/obesity occurrence.
Associations Between Maternal Lipid Blood Levels at the 13th Week of Pregnancy and Offspring’s Adiposity at Age 11-12 Years
Authors: Baas Rosa E , Hutten Barbara A , Henrichs Jens , Vrijkotte Tanja G M 
Published: July 2022

Abstract

Context
There is increasing evidence that intrauterine lipid metabolism influences the adiposity of the newborn and the first years thereafter. It remains unclear if these effects persist when these children grow older.

Objective
This study examined the associations between maternal lipid blood levels during the 13th week of pregnancy and an offspring’s adiposity, measured at age 11-12, and if these associations were moderated by the child’s sex.

Methods
Data were obtained from a community-based birth cohort, the Amsterdam Born Children and their Development (ABCD) study. At a median of 13 weeks’ gestation, nonfasting blood samples of triglycerides (TGs), total cholesterol (TC), free fatty acids (FFAs), and apolipoprotein B/apolipoprotein A1 ratio (ApoB/ApoA1) were measured. An offspring’s body mass index (BMI), subcutaneous fat (SCF), waist-to-height-ratio (WHtR), and fat percentage (fat%) were measured at age 11-12. Mothers with at-term born children were included (n = 1853). Multivariable linear regression analyses were performed to assess the associations between maternal lipids and each offspring’s adiposity outcome separately. Sex differences were additionally evaluated.

Results
TGs, TC, ApoB/ApoA1, and FFAs were significantly positively associated with BMI, WHtR, and fat% (adjusted for gestational age at blood sampling, child’s age, sex, and sexual maturation). After additional adjustments for potential confounders and covariates, only TGs remained significantly associated with WHtR (0.45, 95% CI –0.007; 0.91). There were no associations between maternal lipids and SCF and no clear sex-specific results were found.

Conclusion
Overall, our results do not strongly support that maternal lipid profile during the 13th week of pregnancy has programming effects on adiposity in preadolescence.
Sex-specific Regulation of Prolactin Secretion by Pituitary Bradykinin Receptors
Authors: Abeledo-Machado Alejandra , Peña-Zanoni Milagros , Bornancini Dana , Camilletti María Andrea , Faraoni Erika Yanil , Marcial Agustina , Rulli Susana , Alhenc-Gelas Francois , Díaz-Torga Graciela Susana 
Published: July 2022

Abstract
Sex differences in the control of prolactin secretion are well documented. Sex-related differences in intrapituitary factors regulating lactotroph function have recently attracted attention. Sex differences in prolactinoma development are well documented in clinic, prolactinomas being more frequent in women but more aggressive in men, for poorly understood reasons. Kallikrein, the enzyme releasing kinins has been found in the pituitary, but there is no information on pituitary kinin receptors and their function. In the present work, we characterized pituitary bradykinin receptors (BRs) at the messenger RNA and protein levels in 2 mouse models of prolactinoma, Drd2 receptor gene inactivation and hCGβ gene overexpression, in both males and females, wild type or genomically altered. BR B2 (B2R) accounted for 97% or more of total pituitary BRs in both models, regardless of genotype, and was present in lactotrophs, somatotrophs, and gonadotrophs. Male pituitaries displayed higher level of B2R than females, regardless of genotype. Pituitary B2R gene expression was downregulated by estrogen in both males and females but only in females by dopamine. Activation of B1R or B2R by selective pharmacological agonists induced prolactin release in male pituitaries but inhibited prolactin secretion in female pituitaries. Increased B2R content was observed in pituitaries of mutated animals developing prolactinomas, compared to their respective wild-type controls. The present study documents a novel sex-related difference in the control of prolactin secretion and suggests that kinins are involved, through B2R activation, in lactotroph function and prolactinoma development.
Features of the formation of the hospitality industry of the Vinnytsia region
Authors: Lopatiuk R. 
Published: July 2022

In Ukraine, there are certain limiting problems in the field of tourism positive transformation of this type of activity. Hospitality establishments of the Vinnytsia region are analyzed in the article. It was revealed that with the help of a cluster form of enterprise organization, it is possible to improve the management mechanism, specialization, cooperation, rationally use territorial division and resources.
Examples of improving the standard of living of the population with the help of a cluster mechanism are given, which increases the competitiveness of businesses located in a certain territory, supports an effective business climate and ensures the transition to the integrated use of the potential of the entire state.
A modern view of the causes and mechanisms of the development of acute disseminated peritonitis
Authors: Benedyct V. , Prodan A. , Bahrii V. , Dzhyvak V. 
Published: July 2022

Despite the fact that the diagnosis of acute peritonitis has improved in recent years, a wide range of antibiotics is available, and minimally invasive methods of surgical treatment have been implemented, the mortality rate for this disease is high and ranges from 12.5 % to 39.2 %.
The purpose of the work was to analyze data from literary sources regarding the classification of acute peritonitis, to summarize the causes and mechanisms of its development among the adult population.
Analytical and bibliosemantic research methods were used in the work.
It is known that according to the nature of penetration of microflora into the abdominal cavity, peritonitis is divided into primary, secondary and tertiary. According to the clinical course, peritonitis is divided into acute, subacute and chronic. According to the nature of the exudate in the abdominal cavity, serous, serous-purulent, fibrinous, fibrinous-purulent, purulent, hemorrhagic, fecal and purulent peritonitis are distinguished. To date, the existing classifications are constantly being improved and have both practical and academic significance.
It has long been known that the cause of unsatisfactory results of surgical treatment of patients with acute disseminated peritonitis can be the development of intra-abdominal hypertension with subsequent development of compartment syndrome and multiple organ failure. The development of multiple organ failure is the leading cause of death in patients with acute surgical pathology. Abdominal compartment syndrome plays a big role in this, the mortality in which reaches very significant figures – 42-68 % and without treatment approaches 100 %.
Therefore, the development of acute peritonitis is due to numerous reasons (in particular, acute destructive appendicitis, cholecystitis, perforated ulcer of the stomach or duodenum, intestinal obstruction, tumor processes, gynecological pathology, abdominal injuries, etc.), which in turn causes the absence of a generally recognized justified classification.
The socioeconomic burden of a diagnosis of cervical cancer in women in rural Uganda: findings from a descriptive qualitative study
Authors: Germans Natuhwera , Ellis Peter , Wilson Stanley , Merriman Anne , Rabwoni Martha 
Published: July 2022

Aim: The aim of the study was to diagnose the socioeconomic burden and impact of a diagnosis of cervical cancer in rural women in the context of a low-resourced country, Uganda, through a descriptive qualitative enquiry. Methods: This was a multi-site descriptive qualitative inquiry, conducted at three hospice settings; Mobile Hospice Mbarara in the Southwest, Little Hospice Hoima in Midwest, and Hospice Africa Uganda Kampala in Central Uganda. A purposive sample of women with a histologically confirmed diagnosis of cervical cancer were recruited. Data were collected using open-ended audio-recorded interviews conducted in the native languages of the participants. Interviews were transcribed verbatim in English. Braun and Clarke's (2019) framework of thematic analysis was used. Results: A total of 13 women, with mean age 49.2 years (range 29–71), participated in the study. All participants were of low socioeconomic status. The majority (84.6%) had advanced disease at diagnosis. A detailed reading of transcripts produced three major themes: (1) the impact of cervical cancer on women's relationships (2) the disrupted and impaired activities of daily living (ADLs), and (3) economic disruptions. Conclusions: A diagnosis of cervical cancer introduces significant socioeconomic disruptions in a woman's and her family's life. Cervical cancer causes disability, impairs the woman and her family's productivity and exacerbates levels of poverty in the home. High and expensive out-of-pocket expenditure on investigations, treatments and transport costs further compound the socioeconomic burden.
The relationship between hospital ethical climate and continuing education in nursing ethics
Authors: Okumoto Ayaka , Yoneyama Satoko , Miyata Chiharu , Kinoshita Ayae 
Published: July 2022

BackgroundIn recent years, there has been a growing interest in the importance of creating a healthy ethical climate. Although relationship with various factors and the ethical climate have been reported, understanding of the relationship between ethical education and ethical climate is limited.AimThis study aims to investigate the relationship between ethical climate, personal characteristics, and continuing education for ethics.MethodsThis study conducted a quantitative cross-sectional survey of 605 nurses in 3 teaching hospitals in Japan. Multiple-regression analysis was used to assess the relationship between ethical climate and demographic characteristics and continuing education. Further mean of ethical climate scores were compared between received continuing education and did not, using analysis of covariance adjusted for demographic variables.FindingsThe ethical climate showed significant association with hospital, gender, specialty of the unit, experience of ethics education, in-service ethical training, and workshops/ academic conferences on nursing ethics. In multiple-regression analysis, attending in-service ethical training increased the mean of ethical climate score (p = 0.031) and workshops/ academic conferences decreased the mean score (p = 0.028). Adjusted-mean of ethical climate score of nurses who had in-service training was significantly higher than those who had not (p = 0.038), whereas adjusted-mean of it of nurses who had attended workshops/ academic conferences was significant lower (p = 0.033).DiscussionIn-service training on ethics was associated with the positive ethical climate. Hospital should enhance ethical education.ConclusionEthical climate related to the nurses’ personal characteristics and continuing education. We propose that organizational support for ethical education may be effective in raising the ethical climate of the workplace.
Nutritional status and out-of-hospital mortality in vascular surgery patients
Authors: von Meijenfeldt G. C. I. , Mogensen K. M. , van der Laan M. J. , Zeebregts C. J. , Christopher K. B. 
Published: July 2022

Background
Malnutrition is often present in vascular surgery patient during hospital admission. The present evidence of the consequence malnutrition has on morbidity and mortality is limited.

Aim
The purpose of this study was to determine the effect of nutritional status on out-of-hospital mortality in vascular surgery patients.

Methods
An observational cohort study was performed, studying non-cardiac vascular surgery patients surviving hospital admission 18 years or older treated in Boston, Massachusetts, USA. The exposure of interest was nutritional status categorized as well nourished, at-risk for malnutrition, nonspecific malnutrition or protein-energy malnutrition. The all cause 90-day mortality following hospital discharge was the primary outcome. Adjusted odds ratios were estimated by multivariable logistic regression models.

Results
This cohort included 4432 patients comprised of 48% women and a mean age 61.7 years. After evaluation by a registered dietitian, 3819 patients were determined to be well nourished, 215 patients were at-risk for malnutrition, 351 had non-specific malnutrition and 47 patients had protein-energy malnutrition. After adjustment for age, sex, ethnicity, medical versus surgical Diagnosis Related Group type, Deyo-Charlson index, length of stay, and vascular Current Procedural Terminology code category, the 90-day post-discharge mortality odds ratio for patients with non-specific malnutrition OR 1.96 (95%CI 1.21, 3.17) and for protein-energy malnutrition OR 3.58 (95%CI 1.59, 8.06), all relative to patients without malnutrition.

Discussion
Nutritional status is a strong predictor of out-of-hospital mortality. This suggests that patient with vascular disease suffering from malnutrition could benefit from more intensified In-hospital and out-of-hospital dietary guidance and interventions.
Evaluation of intron-1 of odorant-binding protein-1 of Anopheles stephensi as a marker for the identification of biological forms or putative sibling species
Authors: Singh Om P. , Mishra Shobhna , Sharma Gunjan , Sindhania Ankita , Kaur Taranjeet , Sreehari U. , Das Manoj K. , Kapoor Neera , Gupta Bhavna 
Published: July 2022

BackgroundAnopheles stephensi, an invasive malaria vector, has been reported to have three biological forms identifiable mainly based on the number of ridges present on the egg’s floats. Recently, the first intron of the odorant-binding protein-1 (AsteObp1) has been introduced as a molecular marker for the identification of these forms, and based on this marker, the presence of three putative sibling species (designated as species A, B and C) has been proposed. However, there is no data on the association of proposed markers with biological form or putative species on field populations.MethodsField collected and laboratory-rearedAn.stephensiwere characterized for biological forms based on the number of ridges on the egg’s float. DNA sequencing of the partialAsteObp1gene ofAn.stephensiindividuals were performed by Sanger’s method, either directly or after cloning with a plasmid vector. Additionally,AsteObp1sequences of various laboratory lines ofAn.stephensiwere retrieved from a public sequence database.ResultsAsteObp1intron-1 in IndianAn.stephensipopulations are highly polymorphic with the presence of more than 13 haplotypes exhibiting nucleotides as well as length-polymorphism (90-to-121 bp). No specific haplotype or a group of closely related haplotypes of intron-1 was found associated with any biological form identified morphologically. High heterozygosity for this marker with a low inbreeding coefficient in field and laboratory populations indicates that this marker is not suitable for the delimitation of putative sibling species, at least in Indian populations.ConclusionsAsteObp1cannot serve as a marker for identifying biological forms ofAn.stephensior putative sibling species in Indian populations.
Impact of Endoscopic and Histologic Activity on Disease Relapse in Ulcerative Colitis
Authors: Bessissow Talat , Kron Chelsea Meadler , Marcus Victoria , Lemieux Carolyne , Laneuville Jennifer , Afif Waqqas , Wild Gary , Lakatos Peter L. , Brassard Paul , Bitton Alain 
Published: July 2022

INTRODUCTION:
Endoscopic healing is currently considered the main target in the management of ulcerative colitis (UC). There are conflicting data about the role of histology as a stricter treatment objective. We aim at evaluating the additional benefit of histologic remission over endoscopic remission.

METHODS:
We performed a prospective observational study at the McGill University Health Center. We enrolled adult patients with UC in clinical remission for at least 3 months undergoing a colonoscopy. Endoscopic disease activity was based on the Mayo endoscopic score. Rectal biopsies were obtained, and the histologic activity was evaluated using the Geboes score (active disease defined as Geboes score ≥ 3.1) with the addition of assessing the presence of basal plasmacytosis. Patients were followed up for 12 months for disease relapse defined as a partial Mayo score of > 2. At the time of relapse or end of follow-up, all patients underwent repeat endoscopic evaluation. The primary end point was clinical relapse.

RESULTS:
Two hundred fifty-three patients were included. The presence of basal plasmacytosis was associated with relapse (adjusted odd ratio = 2.07, 95% confidence interval [CI] 1.06–4.18, P = 0.042). Time to clinical relapse was significantly higher for patients with Mayo endoscopic score > 0 with adjusted hazard ratio = 2.65, 95% CI 1.31–5.39, and P = 0.007. Time to clinical relapse was not significantly higher for Geboes score ≥ 3.1 with adjusted hazard ratio = 1.29, 95% CI 0.67–2.49, and P = 0.45.

DISCUSSION:
Active histologic disease did not affect time to clinical relapse in patients with UC who achieved endoscopic remission while the presence of basal plasmacytosis is associated with relapse.
Modelado del fenómeno de remoción de masa para determinar la profundidad de infiltración de la lluvia en el suelo
Authors: Parra Ortega Carlos Arturo , Quintana-Cabeza César , Mosquera-Téllez Jemay 
Published: July 2022

Objetivo: Establecer un modelo dinámico del sistema intensidad de precipitación de agua – porosidad del suelo y velocidad de infiltración a fin de medir la profundidad de infiltración de agua y de humedad en el suelo que producen el deslizamiento.
Metodología: Aplicando Dinámica de Sistemas se desarrolló un diagrama causal de las variables geotécnicas de dos muestras de suelo de sitios afectados por fenómenos de remoción en masa en Pamplona (Colombia); el modelo fue implementado con el software Stella v9.
Resultados: Los resultados de simulación muestran la variación de profundidad de suelo a saturar para alcanzar el límite líquido o la falla debido a esfuerzo cortante.
Conclusiones: La relación entre el fenómeno de remoción en masa y precipitación no coincide con el imaginario colectivo actual sino por un conjunto de valores característico de precipitación para cada tipo de suelo.
Financiamiento: La investigación fue financiada con recursos propios de los autores.
IMPLEMENTASI ALGORITMA GREEDY SEBAGAI PENENTUAN ALOKASI BANDWIDTH SECARA DINAMIS
Authors: Bramantya Mikail Ilham , Santoso Imam , Sofwan Aghus 
Published: July 2022

Penelitian ini bertujuan untuk membuat dan mengimplementasi program alokasi bandwidth dinamis yang dapat mengalokasikan besar bandwidth pada setiap node jaringan berdasarkan keadaan trafik di node tersebut. Pada penelitian ini, Algoritma Greedy digunakan dalam penentuan besar bandwidth karena dianggap mampu dalam memecahkan masalah kombinatorial dalam mengoptimisasi sebuah sistem. Pengujian dilakukan pada jaringan uji coba dan UNDIPConnect Fakultas Teknik Universitas Diponegoro. Berdasarkan hasil pengujian, program berhasil mengambil informasi besar trafik pada jaringan serta mengalokasikan bandwidth ke setiap node sesuai dengan perhitungan. Didapatkan juga rata-rata nilai Jain’s Fairness Index program sebesar 0.585 saat pensimulasian program pada jaringan UNDIPConnect Fakultas Teknik Universitas Diponegoro yang diberi trafik berdasarkan data rekap trafik dari Agustus 2019 hingga Juli 2020.
KONSERVASI ENERGI DAN PENGGUNA ENERGI SIGNIFIKAN DENGAN STUDY CASE FAKULTAS PERIKANAN DAN ILMU KELAUTAN
Authors: Aldianto Mahendra Krisna , Windarta Jaka , Handoyo Eko 
Published: July 2022

Di era kemajuan teknologi dan informasi saat ini, pertumbuhan dan penggunaan energi listrik oleh konsumen tentunya semakin besar dari waktu ke waktu. Oleh karena itu, Konservasi Energi dapat dilakukan untuk mengetahui Informasi rinci tentang penggunaan energi. Berapa besar yang harus dibayar dalam pemakaian energi tersebut, Pengguna potensial terbesar, dan tentunya konservasi energy ini akan mengarah pada rekomendasi dari operasional peralatan maupun proses. Mengacu pada infrastruktur yang membutuhkan penggunaan energi dalam skala besar, Konservasi energi perlu dilakukan untuk menjaga keseimbangan penggunaan rnergi lebih lanjut dalam menjaga Eco saving Energy untuk generasi selanjutnya. Serta, Fakultas Perikanan dan Ilmu Kelautan Universitas Diponegoro dari tahun 2016 hingga 2019 memiliki jumlah konsumsi energi yang cukup besar sebagai sarana prasarana pendidikan yang meliputi dari 13 Fakultas dan 5 unit operasional. Dari fakultas fakultas tersebut tersebar lebih banyak di dalam setiap fakultas yang disebut Unit. Secara keseluruhan, dalam hal ini dari 13 Fakultas dan 5 Unit kami menganalisis secara rinci rekomendasi yang harus dilakukan untuk Fakultas Perikanan dan Ilmu Kelautan Universitas Diponegoro sebagai sarana prasarana gedung pendidikan dan laboratorium, Jurusan ini berjeniskan Non Exact dengan potensi pengguna energi signifikan yang dapat diminimalisir.
IMPLEMENTASI SISTEM PROTEKSI ARUS PADA MOTOR INDUKSI 3 FASA UNTUK APLIKASI SISTEM KONVEYOR TERKENDALI
Authors: Ghozlizar Faizly Van , Handoko Susatyo , Setiawan Iwan 
Published: July 2022

Pada dasarnya pengaplikasian motor induksi tiga fasa banyak di gunakan pada bidang industri, khususnya di bidang kuliner. Di bidang kuliner motor induksi tiga fasa dapat di gunakan sebagai penggerak konveyor untuk pengantaran makanan. Pada motor induksi tiga fasa terdapat arus yang cukup tinggi sehingga bisa menyebabkan motor dapat rusak. Oleh karena itu di perlukan proteksi arus pada motor induksi tiga fasa agar arus yang tinggi pada motor tidak menyebabkan kerusakan pada motor. Dalam tugas ahkir ini, di rancang sistem proteksi arus pada mototr induksi tiga fasa pada sistem konveyor terkendali dengan sensor arus ACS712. Hasilnya sistem proteksi arus yang di rancang dapat melindungi motor induksi tiga fasa saat arus cukup tinggi. Ketika arus melebihi batas yang telah ditetapkan oleh sensor arus ACS712, maka konveyor akan trip.