bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Hyper-Low-Density Lipoprotein and Hypo-High-Density Lipoprotein Cholesterolemia with Low Saliva Flow Rates in Japanese Community-Dwelling Elders
Authors: Mizoguchi Nana , Nohno Kaname , Yoshihara Akihiro , Ito Kayoko , Funayama Saori , Ogawa Hiroshi 
Published: July 2022

Abstract
Introduction The associations of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein (HDL-C) with reduced saliva flow rates have not been previously reported.
Objective The present study aimed to assess the association of cholesterolemia with reduced saliva flow rates in community-dwelling elderly subjects.
Methods The present study analyzed 342 participants (170 males and 172 females aged between 78 and 79 years old). Unstimulated salivary flow rate (USFR) was assessed using a cotton roll method. Low-USFR was defined as 0.10 g/30 seconds. Stimulated salivary flow rate (SSFR) was assessed by having the participants chew tasteless gum for 3 minutes. Low-SSFR was defined as 1.0 mL/minute. Blood samples were collected for the measurement of LDL-C, HDL-C, rheumatoid factor, hemoglobin A1c, and creatinine. To assess depression, the General Health Questionnaire 30 was used. A standardized questionnaire was completed, covering the current and previous medications of the participants and smoking status. We stratified the serum LDL-C levels of the participants as normal, moderate or severe hyper-LDL cholesterolemia and serum HDL-C levels as normal or hypo-HDL cholesterolemia. Multivariate logistic regression models were established and low-USFR or low-SSFR were set as dependent variables in the aforementioned models.
Results After controlling for the effects of the other variables, the odds ratios (ORs) (95% confidence intervals [CIs]) for low-USFR were 2.25 (1.10–4.61) for moderate and 5.69 (1.55–20.8) for severe hyper-LDL cholesterolemia, while that of hypo-HDL cholesterolemia was 3.40 (1.33–8.69). Severe hyper-LDL cholesterolemia was also associated with low-SSFR with an OR of 3.89 (1.39–10.88).
Conclusion Elderly patients with cholesterolemia have a risk of reduced salivary flow rate.
Effect of Application Deviations on Dentin Sealing of a Universal Adhesive: Permeability and Nanoleakage
Authors: Cavalheiro Alexandre , Cruz Joana , Sousa Bernardo , Silva Ana , Eira Raquel , Coito Catarina , Lopes Manuela 
Published: July 2022

Abstract
Objective The objective of this study was to evaluate the effect that deviations from the recommended protocol of a universal adhesive system, applied to dentin according to the self-etch (SE) and the etch-and-rinse (ER) techniques, has on permeability and nanoleakage.
Materials and Methods Permeability: 60 extracted non-carious human third molars (N = 60) were sectioned to obtain 0.7-mm-thick dentin disks. The specimens were randomly assigned to three subgroups and treated with a universal adhesive system (Prime&Bond Active Universal) using the SE and ER techniques: (1) following the manufacturer's instructions with 5 seconds drying (MFR DRY 5S), (2) following the MFR DRY 10S, and (3) reduced application time of the adhesive to 5 seconds (APPL 5S). Nanoleakage: 12 additional 0.7-mm-thick dentin disks were prepared, treated and divided into six groups. They were immersed in 50 wt% ammoniacal silver nitrate and processed according to conventional methods for the analysis of nanoleakage under transmission electron microscopy.
Statistical Analysis The results were statistically analyzed by two-way analysis of variance and post-hoc Bonferroni's test.
Results Significant differences in permeability reduction were observed among the treatment groups (0.001). The results obtained for APPL 5S were significantly lower than the results obtained for both the MFR DRY 5S (p = 0.003) and MFR DRY 10S (p = 0.001).
Conclusions The reduced application time to 5 seconds creates imperfect dentin tubule sealing, which may explain clinical reports of postoperative sensitivity and early degradation of the resin–dentin interface.
Response Bias for Press Ganey Ambulatory Surgery Surveys after Knee Surgery
Authors: Zhang Tina , Schneider Matheus B. , Weir Tristan B. , Shaw Nichole M. , Foster Michael J. , Meredith Sean J. , Leong Natalie L. , Packer Jonathan D. , Henn III R. Frank 
Published: July 2022

AbstractThe Press Ganey Ambulatory Surgery (PGAS) survey is an emerging tool used to capture patient satisfaction after elective surgery. Evaluating patient satisfaction is important; however, quality improvement (QI) surveys used to capture the patient experience may be subject to nonresponse bias. An orthopaedic registry was used to retrospectively identify patients who underwent ambulatory knee surgery from June 2015 to December 2019. Multivariable logistic regression was performed to identify independent predictors of PGAS survey nonresponse and response. In the cohort of 1,161 patients, 142 (12.2%) completed the PGAS survey. Multiple logistic regression demonstrated that male sex, Black race, not living with a caretaker, student or unemployment status, and worse preoperative Patient-Reported Outcomes Measurement Information System (PROMIS) fatigue were predictors of nonresponse. The results of this study highlight the presence of nonresponse bias in the PGAS survey after elective knee surgery.
Cannabidiol Improves Random-Pattern Skin Flap Survival in Rats: Involvement of Cannabinoid Type-2 Receptors
Authors: Aryannejad Armin , Eslami Faezeh , Shayan Maryam , Noroozi Nafise , Hedayatyanfard Keshvad , Tavangar Seyed Mohammad , Jafari Razieh Mohammad , Dehpour Ahmad Reza 
Published: July 2022

AbstractBackground One of the major complications associated with random-pattern skin flaps is distal necrosis. Cannabidiol (CBD) has recently gained much attention as a therapeutic anti-inflammatory agent. We aimed to evaluate the efficacy of CBD on the random-pattern skin flap survival (SFS) in rats and to explore the possible involvement of cannabinoid type-2 (CB2) receptors.Methods In this controlled experimental study, we randomly divided male Wistar rats into seven study groups (six rats each). We performed a random-pattern skin flap model in each rat following pretreatment with vehicle (control) or multiple doses of CBD (0.3, 1, 5, or 10 mg/kg). In a separate group, we injected SR144528 (2 mg/kg), a high affinity and selective CB2 inverse agonist, before the most effective dose of CBD (1 mg/kg). A sham nontreated and nonoperated group was also included. Seven days after surgeries, the percentage of necrotic area (PNA) was calculated. Histopathological microscopy, CB2 expression level, and interleukin (IL)-1β and tumor necrosis factor (TNF)-α concentrations were also investigated in the flap tissue samples.Results A PNA of 72.7 ± 7.5 (95% confidence interval [CI]: 64.8–80.6) was captured in the control group. Following treatment with CBD 0.3, 1, 5, and 10 mg/kg, a dose-dependent effect was observed with PNAs of 51.0 ± 10.0 (95% CI: 40.5–61.5; p <0.05), 15.4 ± 5.8 (95% CI: 9.3–21.5; p <0.001), 37.1 ± 10.2 (95% CI: 26.3–47.8; p <0.001), and 46.4 ± 14.0 (95% CI: 31.7–61.1; p <0.001), respectively. Histopathologically, tissues enhanced significantly. Besides, CB2 expression surged remarkably, IL-1β and TNF-α concentrations decreased considerably after treatment with CBD of 1 mg/kg compared with the control (p <0.05 and <0.001, respectively). Administering SR144528 reversed the favorable effects of CBD of 1 mg/kg, both macroscopically and microscopically.Conclusion Pretreatment with CBD of 1 mg/kg improved SFS considerably in rats and exerted desirable anti-inflammatory effects which were possibly mediated by CB2 receptors.
Preoperative Activity Level an Indicator of Postoperative Functional Outcomes with a Contemporary Revision Total Knee System
Authors: Auran Richard L. , Ashby Samuel L. , Hitt Kirby D. , Jacofsky David J. 
Published: July 2022

AbstractAs the population requiring revision total knee arthroplasty (rTKA) grows, varying preoperative conditions may need to be considered when attempting to predict postoperative outcomes. Considering preoperative activity levels may help manage the expectations of patients. The purpose of this study was to analyze the outcomes of low- and high-activity subgroups of patients receiving a contemporary rTKA. One hundred and eighty-one rTKA patients enrolled in a prospective multicenter study were evaluated over a minimum follow-up of 2 years postoperatively. Patients were divided into two groups based on the preoperative activity level using the Lower Extremity Activity Scale. Patients scoring between 1 and 7 were classified as “Low Activity” (LA; N = 105) and patients scoring 8 to 18 were classified as “High Activity” (HA; N = 76). Clinical outcomes were evaluated, with an additional quality-of-life analysis completed utilizing SF-6D (6-dimension short form) scores obtained through a method described by Brazier et al and analyzed for effect size. There were no significant differences in age or body mass index between the groups. Postoperative improvement in both groups were similar in the Knee Society score (KSS), but the LA group showed larger increases in the KSS functional assessment at 6 months (16.2) and 2 years (34.8). There was a statistically significant effect (0.96, p = 0.0006) seen in the LA group at 1 year, in conjunction with a higher SF-6D outcome. The current study population displayed significant improvement in functional patient outcomes following rTKA regardless of preoperative activity level and function. Patients with lower preoperative activity levels demonstrated greater cumulative functional and quality-of-life improvements. This suggests that a lower preoperative activity level may be related to a poorly functioning knee and that rTKA has the potential to improve overall activity levels and function. Low preoperative function should not disqualify patients for rTKA.
Investigation of the Etiological Causes of Central Nervous System Infection in Children with Multiplex PCR
Authors: Karaaslan Ayşe , Çetin Ceren , Köle Mehmet Tolga , Çağ Yakup , Tekol Serap Demir , Akın Yasemin 
Published: July 2022

Objective The aim of this study is to investigate the causative agents of central nervous system (CNS) infection in hospitalized pediatric patients by multiplex polymerase chain reaction.
Methods We retrospectively reviewed the medical records of children who underwent lumbar puncture with suspected CNS infection between September 2019 and September 2021. The cerebrospinal fluid (CSF) samples were evaluated by the BioFire FilmArray Meningitis/Encephalitis (ME) Panel.
Results The etiology of the infection was established in 13,02% (n = 25) cases. Human herpesvirus (HHV) type 6 was the most commonly identified pathogen 60% (n = 15), followed by enterovirus 20% (n = 5), Streptococcus pneumoniae 8% (n = 2), Streptococcus agalactiae 4% (n = 1), HHV type 1 4% (n = 1), and Listeria monocytogenes 4% (n = 1). The statistical analysis showed that the age of the group with enterovirus was younger than the age of the group with other causative microorganisms and the group with HHV-6 (respectively p: 0.032; p: 0.011). The hospitalization periods of the group with enterovirus and HHV-6 were shorter than the hospitalization periods of the other causative microorganisms (respectively p: 0.016; p: 0.000) and the absolute neutrophil count values of the group with HHV-6 were lower than the group of other causative microorganisms (p: 0.015).
Conclusion Our study identified HHV-6 as the main cause of CNS infection in Istanbul during coronavirus disease 2019 pandemic when isolation measures were taken. The duration of hospital stay was found to be shorter in CNS infection caused by viral agents. Revealing the causative agent in the CSF is a fast and effective method that prevents unnecessary antibiotic treatment and shortens the hospitalization period of patients.
Clinical Profile of Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 Admitted to Pediatric Intensive Care Unit
Authors: Yashaswini Kenchappa , Lalitha Annayappa Venkatesh , Naresh Kanna Giri Subramanian , A. John Michael Raj 
Published: July 2022

Abstract
Objectives Multisystem inflammatory syndrome in children (MIS-C) is a post Severe Acute Respiratory Syndrome Coronavirus2 (SARS CoV2) immune dissonance seen in the pediatric population. The current study is an attempt to understand the subtleties of diverse phenotypes, immunotherapeutics, and short-term outcome parameters of MIS-C.
Materials and Methods Children admitted to the pediatric intensive care unit (PICU) between 1 month and 18 years, satisfying MIS-C criteria, were enrolled in this retrospective observational study. They were stratified into different phenotypes like shock, Kawasaki disease, and nonspecific phenotypes. Respiratory, vasoactive support, and outcomes were analyzed using appropriate statistical methods.
Results Seventy-five children presented with MIS-C during the study period. The mean age was 66 months with 54.6% females. Coronavirus disease (COVID) antibody was positive for 41 (54%), real time-reverse rranscription polymerase chain reaction (RT-PCR) positivity was positive in 16 (21.3%), and rapid antigen test was positive in 10 (13%). Common symptoms included fever (100%), rash (30%), conjunctival congestion (29.7%), and cardiovascular (68% with shock) involvement. Notable differences in shock phenotype were identified including Pediatric Risk of Mortality III score, inflammatory markers, cardiac involvement, need for inotropes, and ventilation. In total, 32% received intravenous immunoglobulin and 48% glucocorticoids. The overall mortality in children with MIS-C was 9 (12%). The need for mechanical ventilation (odds ratio 10.94, confidence interval [2.06, 58.06], p-value <0.005) was noted as an independent predictor of mortality by logistic regression.
Conclusion MIS-C showed a significant cardiovascular involvement at presentation, necessitating intensive care and immunomodulatory therapies. There were higher odds of mortality in the ventilated cohort.
COVID-19 Lung Damage in a Preterm Newborn
Authors: Khalouaoui Amal , Habert Paul , Dequin Marion , Gire Catherine , Tosello Barthélémy 
Published: July 2022

AbstractThe new coronavirus disease 2019 (COVID-19) was declared responsible for a global pandemic by the World Health Organization (WHO) on March 11, 2020. It created, since its emergence, a special concern in neonates given their immature immune system and their frequent contact with caregivers.Monochorionic very preterm female neonate (315/7 weeks of gestation) with growth retardation had at 3 weeks of age severe lung damage following an acute respiratory failure caused by horizontally transmitted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. Before this acute episode, she was without respiratory support apart from 7 days of positive airway pressure following a respiratory distress syndrome. Both of her parents, her twin sister, and her referent nurse tested positive for SARS-CoV-2. Chest radiographs showed bilateral alveolar infiltration. Chest computed tomography (CT) scan detected multiple ground-glass opacifications in both lungs along with ventilation disorders and bronchial wall thickening. Neonate paraclinical tests showed a negative C-reactive protein and hypogammaglobulinemia. Mechanical ventilation was needed for 1 week along with sedation, pharmaceutically induced paralysis, and inhaled nitric oxide. Severe bronchopulmonary dysplasia revealed by oxygen dependency at 36 weeks of gestation was treated with steroids and noninvasive respiratory support. The neonate was discharged with free oxygen at home.Her twin sister, also SARS-CoV-2–positive, only needed noninvasive ventilation for 19 days.Severe forms of COVID-19 in premature neonates, with long-term respiratory sequelae, are possible. Considering the lack of data in this age group, more studies are needed to investigate the risk factors associated with severe symptoms, the effects of specific treatments, and the long-term prognosis of the disease.
Neisseria Meningitidis Serogroup Z–Induced Meningitis: The First Case from Turkey
Authors: Arga Gül , Konca Hatice Kübra , Çelik Ayça Nur , Botan Edin , Çağlayan Utku , Özdemir Halil , Vatansever Göksel , Kendirli Tanıl , Çiftçi Ergin 
Published: July 2022

Abstract
Neisseria meningitidis is a significant worldwide cause of bacterial meningitis and sepsis. High case-fatality rates and severe complications in survivors can occur. We present a 1-month 23-day-old case diagnosed with meningococcal meningitis and sepsis, in which serogroup Z of N. meningitidis was isolated from cerebrospinal fluid and blood cultures and treated with ceftriaxone for 7 days. Our patient is the first case of N. meningitidis serogroup Z–induced invasive meningococcal infection in Turkey. N. meningitidis serogroup Z is not included in the current meningococcal vaccines. It is concerning that a nonvaccine serogroup caused this invasive meningococcal disease and that even if the vaccine would cover this serogroup, it has happened before the usual age of administration. Therefore, meningococcal disease surveillance should continue, and an effective prevention and control strategy for nonvaccine serogroups should be implemented.
Accuracy of Lumbosacral Pedicle Screw Placement in Dogs: A Novel 3D Printed Patient-Specific Drill Guide versus Freehand Technique in Novice and Expert Surgeons
Authors: Bongers Jos J. , Wilkinson Nathan , Kurihara Manabu , Bridges Janis P. , Baltzer Wendy , Worth Andrew J. 
Published: July 2022

Abstract
Objective The aim of this study was to compare the accuracy of pedicle screw placement at the canine lumbosacral junction using a novel unilateral three-dimensional printed patient-specific guide (3D-PSG) versus a freehand drilling technique. Additionally, accuracy of screw placement between a novice and an experienced surgeon was determined.
Study Design Preoperative computed tomography images from 20 lumbosacral cadaveric specimens were used to design a novel unilateral 3D-PSG for the L7 and sacral vertebrae which was printed in acryl-nitrile butadiene styrene plastic. A novice and an expert surgeon each placed 3.5mm cortical screws in 10 cadavers; on the left using the unilateral 3D-PSG and by the freehand (anatomic landmark) technique on the right.
Results Sixty screws were placed using the unilateral 3D-PSG and 60 using the freehand technique. There was no statistical difference in accuracy for the comparison between methods performed by the expert (p = 0.679) and novice (p = 0.761) surgeon, nor between an expert and novice surgeon overall (p = 0.923). Unexpectedly, the use of a unilateral 3D-PSG increased variability for the expert surgeon in our study (p = 0.0314).
Conclusion Using a novel unilateral 3D-PSG did not improve the accuracy of screw placement for lumbosacral stabilization by a novice surgeon compared with an expert surgeon in lumbar spine surgery. This may reflect a suboptimal PSG design.
Abstract Presentation at Two Veterinary Surgery Conferences and the Impact on Publication Rate
Authors: Kettleman William S. , Torres Bryan T. 
Published: July 2022

Abstract
Objectives The aim of this study was to compare the publication rate (PR) and report descriptive findings from abstracts presented at the American College of Veterinary Surgeons (ACVS), the Veterinary Orthopaedic Society (VOS), and those presented at both conferences.
Study Design All conference abstracts from 2001 to 2010 ACVS and VOS meetings were reviewed. PR in peer-reviewed journals was evaluated and compared between Group 1 (abstracts presented at ACVS only; n = 1,277), Group 2 (abstracts presented at VOS only; n = 645), and Group 3 (abstracts presented at both conferences; n = 121) abstracts. Abstracts were assigned a level of evidence (LoE) score.
Results Approximately 6% of all abstracts evaluated were presented at two scientific meetings (Group 3). The PR of Group 1 (66%) and Group 3 (62%) abstracts was significantly higher than that of Group 2 (45%). The majority of abstracts were assigned a low LoE (3 or 4). Once presented, most Group 3 abstracts took <12 months to be submitted and <24 months to be published.
Conclusion This study found that a limited number of abstracts were presented at both ACVS and VOS, and PR was significantly different between those presented at ACVS only or both ACVS and VOS compared with VOS only. There was no significant difference in PR between Group 1 and Group 3 abstracts. This study has provided the initial comparison between abstracts presented at two veterinary surgical conferences.
Lesão de ombro relacionada à administração de vacina: Série de casos
Authors: Cagle Paul J. , White Christopher A. , Patel Akshar V. 
Published: July 2022

Resumo
Objetivo A dor no ombro é um quadro comum na atenção primária e há cada vez mais relatos acerca de sua ocorrência após a vacinação. Este estudo buscou entender como um protocolo de tratamento padronizado ajudaria pacientes com lesão no ombro relacionada à administração de vacina (SIRVA).
Métodos Os pacientes com SIRVA foram recrutados de forma retrospectiva entre fevereiro de 2017 e fevereiro de 2021. Todos os pacientes foram submetidos à fisioterapia e receberam uma prescrição de cortisona injetável. A amplitude de movimento pós-tratamento (ou seja, elevação anterior, rotação externa, rotação interna) e os desfechos relatados pelo paciente foram analisados a partir das pontuações da escala visual análoga (EVA), da American Shoulder and Elbow Surgeons (ASES), do teste simples do ombro (SST) e da avaliação numérica única (SANE).
Resultados No total, 9 pacientes foram examinados de maneira retrospectiva. Entre eles, 6 pacientes foram atendidos no primeiro mês após a vacinação e os outros três, depois de 67, 87 e 120 dias. Ademais, 8 dos pacientes fizeram todo o tratamento fisioterápico e 6 receberam uma injeção de cortisona. O período médio de acompanhamento foi de 8 meses. À última consulta, a rotação externa média foi de 61° (desvio padrão, DP ± 3°) e a elevação anterior média foi de 179° (DP ± 45°). A rotação interna variou entre L3 e T10. As pontuações de dor à EVA foram de 3,5/10,0 (DP ± 2,4) e o escore médio ASES foi de 63,5/100,0 (DP ± 26,3); as pontuações de SST foram 8,5/12,0 (DP ± 3,9). Por fim, os escores de SANE foram de 75,7/100,0 (DP ± 24,7) e 95,7/100,0 (DP ± 6,1) nos ombros lesionados e contralaterais, respectivamente.
Conclusão A dor no ombro após a vacinação tratada com fisioterapia e injeção de cortisona melhorou a amplitude de movimento e os escores funcionais.
Nível de Evidência IV.
Endovascular Embolisation Using N-Butyl-2-Cyanoacrylate: An Effective Treatment Option for Uterine Artery Pseudoaneurysm in Postpartum Hemorrhage
Authors: Pothula Venkatesh , Dhanasekaran Jagadeesan , Nekkala Jyothsna , Sekar Sabarish , Joseph Santhosh 
Published: July 2022

AbstractIn this case series, we evaluated the efficacy and safety of uterine artery embolization (UAE) using N-butyl- 2-cyanoacrylate (NBCA)/glue for the treatment of uterine artery pseudoaneurysm (UAP). Here, we report 8 patients with uterine artery pseudoaneurysm, who underwent UAE using NBCA/glue. Angiograms and medical records were retrospectively analyzed to determine the technical success, clinical success, complications, average procedure time, the average duration of hospital stay after UAE. All patients were presented with secondary postpartum hemorrhage with hemodynamic instability. The technical and clinical success rates were 100%, respectively. The average procedure time was 21minutes and the average duration of hospital stay was 2.2 days. We did not encounter any major complications. Two patients following UAE were naturally conceived and delivered by repeat LSCS. UAE using NBCA/glue is a safe and effective treatment option for UAP in both hemodynamically stable and unstable patients.