bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reaksi Investor Pada Saham Perusahaan Sub Sektor Perhotelan, Restoran Dan Pariwisata Pada Masa Pandemi Covid
Authors: Krismawati Via , Maslichah Maslichah , Sudaryanti Dwiyani 
Published: November 2022

Covid Pandemic has multidimensional effect to economic activity. It affects investor reaction to the prospect of industrial sector in Indonesia. The objective of this study aims to study the investor reaction during Covid pandemic on the shares of hospitality industry, restaurant, and tourism subsector The population of this research is hospitality industry, restaurant, and tourism subsector on the BEI with purposive sampling as its technique. The proxy of investor reaction is Average Trading Volume Activity in monthly basis. This study compares two period of reaction, 7 months before Pandemic and 7 months during Covid Pandemc. The data were analyzed using paired t test. The results showed that there was no difference between before and during Covid Pandemic. Investors are still positive on the prospect of hospitality industry, restaurant, and tourism subsector. It implies on a need of a supportive policy from government to keep the investor’s trust, such as issuing tax amnesty for those industry.
Optimization of Adaptive Threshold in Tumor Segmentation Based on I-124 PET/CT NEMA Phantom Study
Authors: Vijayarao Dhanessha , Musarudin Marianie , Said Aminudin 
Published: November 2022

Numerous methods have been introduced to segment the thyroid tumors in iodine-124 (124I) Positron Emission Tomography/Computer Tomography (PET/CT) imaging. An adaptive threshold-based is preferable to a manual and fixed threshold-based approach for forecasting accurate and precise tumor volume in real-patient studies, as it was reported to be more resistant to noise and resolution. Manual segmentation was reported to be time-consuming, subjective, subject to inter- and intra-observer variability and prone to segmentation errors [1]. This study aimed to determine the optimal adaptive threshold for thyroid tumor segmentation in 124I PET/CT imaging.

The objective of this study was firstly to determine the segmented volume using the standardized uptake value threshold method. Secondly, to compare the adaptive threshold and recovery coefficient (RC) value between the time of flight (TOF) and non-time of flight (non-TOF) PET/CT reconstructions in 124I phantom studies. Finally, to determine the accuracy and RC for 124I PET/CT studies. This study was done by placing NEMA 2012/IEC 2008 PET IQ Phantom and filled with 1 kBq/ml and 20 kBq/ml in its background and sphere each to model tumor background ratio (TBR) 20:1 of 124I PET/CT imaging. The phantom was scanned using TOF and non-TOF PET at 3, 4 and 5 minutes per bed position and reconstructed using 600, 1200 and 2000 beta penalization factors. Image registration, contouring and segmentation were performed using MIM Encore Software. A set of different adaptive thresholds (Tadaptive: 10%-50%) was applied to each sphere in the TBR image of the phantom using the tri-dimensional automatic segmentation tool. The optimal Tadaptive for each of the parameter assessed was defined based on the lowest goodness value calculated. The RC was calculated using mean value and known activity. Finally, the RC against the percentage of maximum was plotted to analyse the descending order of beta penalization factors for time per bed position.

Figure 1 shows the image of 124I contoured VOIs on the spheres. The results showed that segmented volumes were not affected by the time per bed position in 124I PET/CT imaging. Table 1 shows the descending order beta penalization factors for time per bed position. Beta penalization factors of 600 to 2000 resulted in either underestimation or overestimation of the measured volume. Comparing TOF to non-TOF PET/CT 124I imaging, consistent and reproducible data were observed for the TOF PET for the three beta penalization factors. Tadaptive of 28.0% consistently gave the lowest goodness value shown by the closest R2 value to one, thus can produce lowest error if it is being used to reconstruct images.
As a conclusion, 28% Tadaptive is suggested as the optimal threshold for 124I TOF PET/CT imaging due to consistent data obtained for all beta penalization factors assessed in this study. The inconsistent data obtained by non-TOF PET thus requires further optimization.
Apoptosis Event in Hela Cells Treated with Cisplatin, Gallic Acid and Combination of Both
Authors: Sazeli Syahirah , Abdullah Hasmah , Hapidin Hermizi , Sulong Sarina 
Published: November 2022

Adverse effect of conventional chemotherapeutic agent using single anticancer drugs had led to application of combination therapy in cancer treatments. Combination of polyphenolic compounds and anticancer agent was studied and shown promising outcomes in vitro. In cancer treatment, mode of cell death through apoptosis is one of the targeted approaches in many preclinical drug development studies and has been identified as a key mechanism of chemotherapy-induced cell death.

Hence, this study was conducted to evaluate the apoptosis event of HeLa cells treated with gallic acid (GA) combined with cisplatin (CIS). HeLa cells were treated for 24,48 and 72 hours with CIS and GA at IC50 (Table 1) concentrations, and the combination of CIS and GA (CIS– GA) was chosen based on a previous study (66.73 percent cell inhibition [1]. To compare the anticancer effects of cisplatin and gallic acid individually and in-combination on apoptosis in HeLa cells, flow cytometry assay was carried out.
According to the findings, during every incubation period, the CIS-GA combination treatment group consistently showed the highest level of antiproliferative activity in HeLa cells, followed by the CIS and GA treatment group. CIS and GA combined treatment response was time-dependent, with an increase in apoptotic cells as incubation time increase (Figure 1). At 72 hours, the combination of CIS and GA treatment showed a significant improvement (74.6%), and improvements were also shown after 24 and 48 hours (56 percent and 60.2 percent).
Taken together, these findings suggest that combination therapy enhances the cell death magnitude in HeLa cells. Additionally, these findings have positive implications for the use of a combination therapy approach in cancer treatment.
Anti-proliferative and Apoptosis Inducing Effects of Gallic Acid on Human Acute Myeloid Leukaemia Cell Lines (HL-60)
Authors: Mohd Roba’ei Dalyana Raisa , Wan Osman Wan Nurfarahin , Mohd Zainudin Hudaa Zulfa , Abdul  Aziz Muhammad Yusran , Tuan Johari Syed Ahmad Tajudin 
Published: November 2022

Gallic acid (GA) comes from benzoic acid or, more specifically, 3,4,5-tryhydroxybenzoic, which derives from the phenolic acid of the non-flavonoid part of the polyphenol compound. It is found ubiquitously in various plants and fruits, such as grapes, gallnuts, pomegranates, and tea leaves [1]. Many scientific journals and articles reported on the pharmacological properties of the photochemical like GA, which has antioxidant properties, antimicrobial, anti-inflammatory, anticancer, cardioprotective, gastroprotective, and neuroprotective activity [2]. Moreover, the anticancer properties of GA have been recognised in several cancers, such as lung cancers, oesophageal cancer cells and leukaemia [3].

The objective of this study is to examine the anti-proliferative and apoptosis inducing effects of GA on HL-60 cell lines. Six concentrations of GA were made using the stock solution of GA compound dissolved in dimethyl sulfide (DMSO). HL-60 cells were treated with concentrations of 100, 50, 25, 12.5, 6.25, and 3.125 µg/mL and was incubated at three incubation period which were 24, 48, and 72 hours. The quantitative measure was determined with cytotoxicity assay of 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and was read by microplate reader at 570 nm. For qualitative measure was through staining with acridine orang (AO) and propidium iodide (PI) and observed the morphological changes of the treated cells.

Results from the MTT assays show that GA has cytotoxicity effect on HL-60 cells especially for 72 hours incubation period. The maximal half inhibitory concentrations (IC50) value of GA decreases as incubation period increases. The IC50 of GA were 9.03, 6.76, and 3.65 µg/ml for 24-, 48-, and 72-hours incubation, respectively. The IC50 value of GA (p<0.05) was significantly different for different incubation periods. The morphological changes were seen through the AO/PI staining with the appearance of the cell blebbing, early apoptosis, and late apoptosis.

Figure 1 shows early apoptosis (EA), late apoptosis (LA), cell blebbing (CB), membrane loose (MB), nuclear fragmentation (NF), and apoptotic bodies (AB).

These findings show that GA has potential as anti-proliferative and apoptosis inducing effects on HL-60 cells line. More research is needed to determine the pathways of apoptosis in HL-60 treated with GA.
Tuberculosis (TB) Mucosal Vaccines: Current Efforts and Future Approaches
Authors: Mohd Asri Nur Ain , Xuan Keh Min , Suppian Rafeah , Mohd Nor Norazmi , Azlan Maryam , Camacho Frank 
Published: November 2022

It is now known that the existing vaccination, Bacille Calmette-Guérin (BCG), is unable to stop the global Tuberculosis (TB) epidemic, and TB continues to pose a serious threat to public health [1]. Mycobacterium tuberculosis (Mtb), the causing agent, enters the body by inhalation, causing TB predominantly a respiratory infection [1]. Therefore, there is solid evidence to support the idea that a mucosally administered TB vaccination would be more successful than one administered systemically. Our team in Universiti Sains Malaysia (USM) has been working with several organisations in conjunction with Malaysia’s National Vaccine Roadmap (PPVN) to address this problem as well as the government's goal to produce vaccines that are high-quality, efficient, and secure following the guidelines established by the National Pharmaceutical Regulatory Agency (NPRA).
Therefore, the development of TB mucosal vaccines over the past few years for worldwide as well as in USM is outlined in this presentation. It aims to discuss immunological and practical factors in the development of mucosal vaccines and emphasises some of the current and future approaches in USM.
As a result, it is acknowledged globally that matching the path of infection with the path of immunisation is an appealing strategy for the development of TB vaccines. Several approaches have been made in USM to produce a vaccine candidate that significantly induces mucosal immunity. The design of the study showed the manipulation of IgA, which is a hallmark of mucosal immunity, with multi-epitopes of TB to produce IgA: TB recombinant protein by using goat’s milk as a bioreactor. The concept of oral immunisation in-vivo also is an important approach in our effort to maximise the production of the immune system at the point of entry of bacteria.
In a conclusion, as a boost to a prior respiratory or systemic immunisation, the mucosal method might be more effective. In addition to systemic immunity obtained by injected vaccines, vaccines to induce pathogen-specific IgA are being developed to provide a first line of defence at these entry sites. Therefore, combining these concepts into developing new recombinant vaccine against TB would be a promising alternative.
Prevalence of Piperacillin-Tazobactam induced Hypersensitivity Reaction in Workers of Stallion’s Pharmaceutical Factory at Lahore
Authors: Anwar Ali Sulehri  , Hafiz Muhammad Hammad Yaqub  , Humayun Suqrat Hassan Imam  , Uzma Sagheer  , Muhammad Abubakar  
Published: November 2022

BACKGROUND & OBJECTIVE: Piperacillin is an antibiotic that belongs to the ureidopenicillin family. Piperacillin-tazobactam provides cover against gram-positive, gram-negative bacteria and some bacteria of anaerobic nature. It is an extended-spectrum antibiotic and is used along with tazobactam which is an inhibitor of beta-lactamase. The main objective of our research was to identify the hypersensitivity reactions of piperacillin-tazobactam in pharmaceuticals factory and office workers.
METHODOLOGY: A Cross-sectional study was conducted at Stallion Pharmaceuticals (Pvt) Ltd located at Sundar Industrial Estate Lahore, Pakistan, from March to April 2018, after approval from the institutional research committee. All the workers, including factory workers and office workers at Stallion Pharmaceuticals (Pvt) Ltd were included in this study. Data was collected from each respondent by immediate-type skin testing. Data analysis was done by SPSS version 25, the demographic data was evaluated by descriptive statistics, Fisher Exact test was used for comparison and p≤0.05 was taken as significant.
RESULTS: The results of the study presented that hypersensitivity reaction was present in (7.5%) of males and (3.8%) of females. It was also observed that (8.8%) of factory workers had hypersensitivity reactions when they are gone through skin tests, and only (2.5%) of office workers were skin test positive. From the above results (11.2%) of all the respondents developed hypersensitivity reactions and (88.8%) showed no reaction when they were gone through skin tests, which contain 0.1 ml of piperacillin and tazobactam. Fisher exact test was applied, and results showed no significant difference between hypersensitivity reactions among factory and office workers as the p-value was 01.
CONCLUSION: Hypersensitivity reaction to piperacillin-tazobactam was minimal in the factory & office workers, and this was not significant.
Enjeux théoriques et pratiques de l’encadrement syndical des migrants
Authors: Pujals i Lladó Marc 
Published: November 2022

Les vagues migratoires espagnoles vers la France deviennent un phénomène massif entre la fin des années 1950 et la première moitié des années 1970. La présence en France d’une importante colonie d’exilés politiques et de syndicats démocratiques inquiète les agents de la dictature franquiste qui cherchent à surveiller et contrôler les nouveaux arrivants, à savoir, des chômeurs et des jeunes travailleurs précaires – hommes comme femmes – pour la plupart d’entre eux. Cet article se concentre sur les dynamiques de politisation et de mobilisation sociale et professionnelle mises en place par ces migrants dits « économiques » à travers leurs interactions avec le monde syndical français et plus spécifiquement avec la CGT et la CFDT.
Sons et images de guerre : une relation incongrue ?
Authors: Tahon Benoit 
Published: November 2022

En raison de l’usage massif d’armes puissantes et destructrices engendrant chez les combattants des traumatismes d’ampleur jusque-là inégalée, la Première Guerre mondiale a imposé aux artistes la nécessité de moderniser les formes habituelles de la représentation de la bataille. Comment, dès lors, traduire visuellement les multiples sonorités de l’univers combattant ? L’article se propose de reconsidérer la relation « incongrue » de l’image et du son à travers les deux modes de représentation que sont la peinture et la photographie.
Élie Kagan, photographe indépendant, 1960-1990
Authors: Manceron Gilles 
Published: November 2022

Un bel ouvrage éponyme garde trace de l’exposition présentée du 19 janvier au 7 mai 2022 à La contemporaine, « Élie Kagan, photographe indépendant 1960-1990 », sous la direction de ses commissaires, Cyril Burté, conservateur, responsable des archives audiovisuelles à La contemporaine, et Audrey Leblanc, historienne de la photographie, chercheuse associée à l’EHESS et à l’INA. Ce livre constitue la première approche globale de l’œuvre de ce « photographe d’archive et d’histoire ».
Rouben, Le défi de l’indépendance. Arménie (1919-1920) , préface de Taline Ter Minassian et Anahide Ter Minassian, traduction de Waïk Ter Minassian, postface de Robert Ilbert, Éditions Thaddée, 2021, 217 p., 25 €
Authors: Cœuré Sophie 
Published: November 2022

Cet article propose un compte rendu de l’ouvrage de Minas Ter Minassian, alias Rouben, Le défi de l’indépendance. Arménie (1919-1920) (Thaddée, 2021), qui fut l’un des principaux dirigeants de l’éphémère République d’Arménie, puis du parti « Dachnak » en exil à Paris.
L’intermittence du spectacle, un financement paradoxal de la culture ?
Authors: Sigalo Santos Luc 
Published: November 2022

Les règles d’indemnisation du chômage des artistes et techniciens intermittents du spectacle sont régulièrement présentées dans les médias comme un « privilège » national et sectoriel. Par-delà les clichés, l’intermittence permet surtout de compenser la discontinuité de l’emploi et des revenus dans un domaine où le travail par projets est la norme. Dans le même temps, son fonctionnement met à l’épreuve les logiques bureaucratiques standardisées d’administrations telles que Pôle emploi.
La K-pop : des formules inédites couronnées de succès
Authors: Parc Jimmyn , Messerlin Patrick 
Published: November 2022

On affirme souvent que la culture doit être protégée et préservée, et qu’il doit en être de même pour les produits culturels. Cependant, l’émergence internationale de la musique pop coréenne ou K-pop raconte une histoire bien différente – celle d’une industrie qui a su saisir au vol toutes les opportunités offertes par la mondialisation et l’arrivée du numérique comme nouveau vecteur culturel. De plus, l’exercice stratégique des droits d’auteur adopté dans ce contexte par les entreprises concernées a permis d’amplifier la diffusion de la K-pop dans le monde. Celle-ci s’est alors imposée comme une nouvelle composante de la diversité culturelle mondiale ; le soft power de la Corée s’en est trouvé considérablement renforcé.
De l’art ou de la spéculation ? Ce que nous apprend le xix e siècle sur la valeur des œuvres
Authors: Saint-Raymond Léa 
Published: November 2022

La valeur des œuvres d’art dépend moins de déterminants strictement économiques, que des rapports de force entre différents « prescripteurs ». Cet article identifie les processus de valorisation artistique et en étudie les principaux acteurs à la lumière du xix e siècle parisien : l’irrésistible ascension de logiques considérées comme purement spéculatives témoigne en réalité d’un effacement du système académique face aux professionnels du marché.
Insertion professionnelle selon le handicap et le sexe
Authors: Collet Marc , Lhommeau Bertrand 
Published: November 2022

Comment les politiques visant l’emploi des personnes handicapées prennent-elles en compte le genre ? À partir d’un travail de revue de littérature et de deux enquêtes par méthodes mixtes, cet article propose trois contributions essentielles à la réflexion. Tout d’abord, sur le plan historique, les politiques visant l’emploi des personnes handicapées ont été fondées sur un modèle de travailleur masculin, héritier notamment de la figure du mutilé de guerre. Ensuite, cet héritage a des conséquences différenciées selon le sexe, en dépit d’une neutralisation formelle des politiques sur le plan du genre, du fait des types de handicap que ces politiques ciblent en priorité. Enfin, se reproduisent au sein des politiques visant les « travailleurs handicapés » des inégalités de genre classique, liées par exemple à une attente de disponibilité totale pour la recherche d’emploi, ou encore à une hiérarchie sexuée des métiers au sein du travail protégé.
Femmes handicapées, les invisibles dans l’emploi
Authors: Desaint Claire 
Published: November 2022

L’emploi des femmes handicapées se heurte à des obstacles qui se multiplient en raison de leur handicap, de l’inaccessibilité, mais surtout parce qu’elles sont des femmes. Leur participation à la vie économique est freinée par des préjugés, des stéréotypes dans toutes les dimensions de l’emploi : éducation, orientation, recrutement, chômage, carrière professionnelle, articulation des temps, retraites. Elles sont peu invisibles dans les publications des études et statistiques, d’où leur absence dans les politiques publiques sur le handicap et sur l’égalité femmes-hommes jusque très récemment. Les femmes handicapées font partie des populations les plus marginalisées et vivant dans la précarité. Il est temps que la société change son regard et considère les femmes handicapées non plus comme une charge, mais comme détentrices de talents, de compétences et d’expertise. Les femmes handicapées sont porteuses de changement et représentent un atout pour les entreprises et les institutions.
Venom of the giant ant Dinoponera quadriceps attenuates inflammatory pain in mouse cutaneous wound healing model
Authors: Assreuy Ana Maria Sampaio , Adjafre Beatriz Lima , Sousa Évilla Rayanne Oliveira , Alves Ana Paula Negreiros Nunes , Pires Alana de Freitas , Quinet Yves , Mota Mário Rogério Lima 
Published: November 2022

Arthropod venoms are potential sources of bioactive substances, providing tools for the validation of popular use and new drugs design. Ants belonging to the genus Dinoponera are used in the folk medicine to treat inflammatory conditions. It was previously demonstrated that the venom of the giant ant Dinoponera quadriceps (DqV), containing a mixture of polypeptides, elicit antinociceptive effect in mice models of chemical, mechanical and thermal nociception. The aim of this study was to evaluate DqV antiinflammatory and antihypernociceptive effects in a mice model of traumatic cutaneous wound. Colonies of D. quadriceps were collected in the ‘Serra de Maranguape’ (State of Ceará, northeastern Brazil), a small mountain range located on the coastal zone, and the venom secreted by the ant glands was extracted with capillary tubes, further lyophilized and maintained at -20 ± 1ºC until use. Wounds were performed in the dorsum of Swiss mice. Animals received intravenous (i.v.) injection of DqV (50 µg kg-1 day-1) during 3 days for evaluation of inflammatory parameters present in the wounds: hypernociception, leukocyte infiltrate, myeloperoxidase activity, nitrite/nitrate content. Data was tested by two-way ANOVA and Bonferroni’s post-hoc test. DqV reduced (2.7 folds) hypernociception at 48 hours, leukocyte infiltration by 65% at 6 hours and myeloperoxidase activity by 60% at 0.5 hour after wound induction. In conclusion, the venom extracted from D. quadriceps glands attenuates inflammation and hypernociception in mice cutaneous wounds.
Infecciones transmisibles sexualmente que afectan colon, recto y ano.
Authors: La Rosa Luciana , Svidler López Laura 
Published: November 2022

Dedicamos este relato a todos aquellos que día a día luchan por ser visibilizados: a las mujeres en general y a las cirujanas en particular; a los hispano parlantes, principalmente de lugares que no pertenecen al denominado primer mundo; a los que producen conocimiento en países no hegemónicos; a los que tienen un acceso dificultoso al sistema de salud y, en especial, a los que padecen infecciones sexualmente transmisibles y no encuentran a un profesional integralmente preparado para atenderlos.