bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do we need repeated CT imaging in uncomplicated blunt renal injuries? Experiences of a high-volume urological trauma centre
Authors: Lindner Andrea Katharina , Luger Anna Katharina , Fritz Josef , Stäblein Johannes , Radmayr Christian , Aigner Friedrich , Rehder Peter , Tulchiner Gennadi , Horninger Wolfgang , Pichler Renate 
Published: July 2022

Abstract
Background
Current guidelines recommend repeat computed tomography (CT) imaging in high-grade blunt renal injury within 48–96 h, yet diagnostic value and clinical significance remain controversial. The aim of this work was to determine the possible gain of CT re-imaging in uncomplicated patients with blunt renal trauma at 48 h after injury, presenting one of the largest case series.

Methods
A retrospective database of patients admitted to our centre with isolated blunt renal trauma due to sporting injuries was analysed for a period of 20 years (2000–2020). We included only patients who underwent repeat imaging at 48 h after trauma irrespective of AAST renal injury grading (grade 1–5) and initial management. The primary outcome was intervention rates after CT imaging at 48 h in uncomplicated patients versus CT scan at the time of clinical symptoms.

Results
A total of 280 patients (mean age: 37.8 years; 244 (87.1%) male) with repeat CT after 48 h were included. 150 (53.6%) patients were classified as low-grade (grade 1–3) and 130 (46.4%) as high-grade (grade 4–5) trauma. Immediate intervention at trauma was necessary in 59 (21.1%) patients with high-grade injuries: minimally invasive therapy in 48 (81.4%) and open surgery in 11 (18.6%) patients, respectively. In only 16 (5.7%) cases, intervention was performed based on CT re-imaging at 48 h (low-grade vs. high-grade: 3.3% vs. 8.5%; p = 0.075). On the contrary, intervention rate due to clinical symptoms was 12.5% (n = 35). Onset of clinical progress was on average (range) 5.3 (1–17) days post trauma. High-grade trauma (odds ratio [OR]grade 4 vs. grade 3, 14.62; p < 0.001; ORgrade 5 vs. grade 3, 22.88, p = 0.004) and intervention performed at the day of trauma (OR 3.22; p = 0.014) were powerful predictors of occurrence of clinical progress.

Conclusion
Our data suggest that routine CT imaging 48 h post trauma can be safely omitted for patients with low- and high-grade blunt renal injury as long as they remain clinically stable. Patients with high-grade renal injury have the highest risk for clinical progress; thus, close surveillance should be considered especially in this group.
RETRACTED ARTICLE: Perioperative left ventricular perforation in incomplete TAVI and completion of the procedure after surgical repair
Authors: Nasso Giuseppe , Santarpino Giuseppe , Contegiacomo Gaetano , Balducci Giuseppe , Valenzano Antongiulio , Moranti Enrico , Scaringi Domenico , Speziale Giuseppe , Condello Ignazio 
Published: July 2022

Abstract
Background
The use of transcatheter aortic valve implantation (TAVI) continues to grow worldwide. Despite increased operator experience, evolution of the technique, and deflectable catheters, major complications still occur in ≤ 6% up to 8% of cases. Such major complications have been associated with a 2- to threefold increase in 30-day mortality. Complications specifically involving the aorta, aortic valve annulus, or left ventricle are rare, occurring in only 0.2–1.1% of cases.

Case presentation
We report the case of a 65-year-old female patient with left ventricular lateral wall perforation during incomplete implantation of a TAVI device, and successive percutaneous completion after surgical repair of the lesion under cardiopulmonary bypass. The surgical strategy and the type of surgical treatment depend on the type of perforation. In general, repair of the lesion and aortic valve replacement are performed. Removal of the TAVI prosthesis and excision of the native aortic valve are standard parts of this repair.

Conclusion
Here we propose a safe alternative for the completion of the TAVI approach after surgical repair, which requires close coordination between the members of the heart team (anesthesiologist, perfusionist, cardiologist, nurse and cardiac surgeon).
Recent progress on vascular endothelial growth factor receptor inhibitors with dual targeting capabilities for tumor therapy
Authors: Liu Yun , Li Yang , Wang Yuxi , Lin Congcong , Zhang Dan , Chen Juncheng , Ouyang Liang , Wu Fengbo , Zhang Jifa , Chen Lei 
Published: July 2022

AbstractVascular endothelial growth factor receptors (VEGFRs) are a family of receptor protein tyrosine kinases that play an important role in the regulation of tumor-induced angiogenesis. Currently, VEGFR inhibitors have been widely used in the treatment of various tumors. However, current VEGFR inhibitors are limited to a certain extent due to limited clinical efficacy and potential toxicity, which hinder their clinical application. Thus, the development of new strategies to improve the clinical outcomes and minimize the toxic effects of VEGFR inhibitors is required. Given the synergistic effect of VEGFR and other therapies in tumor development and progression, VEGFR dual-target inhibitors are becoming an attractive approach due to their favorable pharmacodynamics, low toxicity, and anti-resistant effects. This perspective provides an overview of the development of VEGFR dual-target inhibitors from multiple aspects, including rational target combinations, drug discovery strategies, structure–activity relationships and future directions.
Comparison of diagnostic criteria for acute kidney injury in critically ill children: a multicenter cohort study
Authors: Kuai Yuxian , Li Min , Chen Jiao , Jiang Zhen , Bai Zhenjiang , Huang Hui , Wei Lin , Liu Ning , Li Xiaozhong , Lu Guoping , Li Yanhong 
Published: July 2022

Abstract
Background
Substantial interstudy heterogeneity exists in defining acute kidney injury (AKI) and baseline serum creatinine (SCr). This study assessed AKI incidence and its association with pediatric intensive care unit (PICU) mortality under different AKI and baseline SCr definitions to determine the preferable approach for diagnosing pediatric AKI.

Methods
In this multicenter prospective observational cohort study, AKI was defined and staged according to the Kidney Disease: Improving Global Outcome (KDIGO), modified KDIGO, and pediatric reference change value optimized for AKI (pROCK) definitions. The baseline SCr was calculated based on the Schwartz formula or estimated as the upper normative value (NormsMax), admission SCr (AdmSCr) and modified AdmSCr. The impacts of different AKI definitions and baseline SCr estimation methods on AKI incidence, severity distribution and AKI outcome were evaluated.

Results
Different AKI definitions and baseline SCr estimates led to differences in AKI incidence, from 6.8 to 25.7%; patients with AKI across all definitions had higher PICU mortality ranged from 19.0 to 35.4%. A higher AKI incidence (25.7%) but lower mortality (19.0%) was observed based on the Schwartz according to the KDIGO definition, which however was overcome by modified KDIGO (AKI incidence: 16.3%, PICU mortality: 26.1%). Furthermore, for the modified KDIGO, the consistencies of AKI stages between different baseline SCr estimation methods were all strong with the concordance rates > 90.0% and weighted kappa values > 0.8, and PICU mortality increased pursuant to staging based on the Schwartz. When the NormsMax was used, the KDIGO and modified KDIGO led to an identical AKI incidence (13.6%), but PICU mortality did not differ among AKI stages. For the pROCK, PICU mortality did not increase pursuant to staging and AKI stage 3 was not associated with mortality after adjustment for confounders.

Conclusions
The AKI incidence and staging vary depending on the definition and baseline SCr estimation method used. The modified KDIGO definition based on the Schwartz method leads AKI to be highly relevant to PICU mortality, suggesting that it may be the preferable approach for diagnosing AKI in critically ill children and provides promise for improving clinicians’ ability to diagnose pediatric AKI.
A high-resolution single-molecule sequencing-based Arabidopsis transcriptome using novel methods of Iso-seq analysis
Authors: Zhang Runxuan , Kuo Richard , Coulter Max , Calixto Cristiane P. G. , Entizne Juan Carlos , Guo Wenbin , Marquez Yamile , Milne Linda , Riegler Stefan , Matsui Akihiro , Tanaka Maho , Harvey Sarah , Gao Yubang , Wießner-Kroh Theresa , Paniagua Alejandro , Crespi Martin , Denby Katherine , Hur Asa ben , Huq Enamul , Jantsch Michael , Jarmolowski Artur , Koester Tino , Laubinger Sascha , Li Qingshun Quinn , Gu Lianfeng , Seki Motoaki , Staiger Dorothee , Sunkar Ramanjulu , Szweykowska-Kulinska Zofia , Tu Shih-Long , Wachter Andreas , Waugh Robbie , Xiong Liming , Zhang Xiao-Ning , Conesa Ana , Reddy Anireddy S. N. , Barta Andrea , Kalyna Maria , Brown John W. S. 
Published: July 2022

AbstractBackgroundAccurate and comprehensive annotation of transcript sequences is essential for transcript quantification and differential gene and transcript expression analysis. Single-molecule long-read sequencing technologies provide improved integrity of transcript structures including alternative splicing, and transcription start and polyadenylation sites. However, accuracy is significantly affected by sequencing errors, mRNA degradation, or incomplete cDNA synthesis.ResultsWe present a new and comprehensiveArabidopsis thalianaReference Transcript Dataset 3 (AtRTD3). AtRTD3 contains over 169,000 transcripts—twice that of the best current Arabidopsis transcriptome and including over 1500 novel genes. Seventy-eight percent of transcripts are from Iso-seq with accurately defined splice junctions and transcription start and end sites. We develop novel methods to determine splice junctions and transcription start and end sites accurately. Mismatch profiles around splice junctions provide a powerful feature to distinguish correct splice junctions and remove false splice junctions. Stratified approaches identify high-confidence transcription start and end sites and remove fragmentary transcripts due to degradation. AtRTD3 is a major improvement over existing transcriptomes as demonstrated by analysis of an Arabidopsis cold response RNA-seq time-series. AtRTD3 provides higher resolution of transcript expression profiling and identifies cold-induced differential transcription start and polyadenylation site usage.ConclusionsAtRTD3 is the most comprehensive Arabidopsis transcriptome currently. It improves the precision of differential gene and transcript expression, differential alternative splicing, and transcription start/end site usage analysis from RNA-seq data. The novel methods for identifying accurate splice junctions and transcription start/end sites are widely applicable and will improve single-molecule sequencing analysis from any species.
The impact of resistance exercise range of motion on the magnitude of upper-body post-activation performance enhancement
Authors: Krzysztofik Michał , Trybulski Robert , Trąbka Bartosz , Perenc Dawid , Łuszcz Konrad , Zajac Adam , Alexe Dan Iulian , Dobrescu Tatiana , Moraru Cristina Elena 
Published: July 2022

Abstract
Background
Various studies have used different exercise protocols as post-activation performance enhancement (PAPE) stimulus; however, little attention has been given to the effects of exercise range of motion on the PAPE effect and subsequent performance enhancement. This study aimed to compare the PAPE responses induced by the bench press performed with different ranges of motion on subsequent bench press throw performance.

Methods
Ten resistance-trained males (age: 26 ± 3 years; body mass: 93.2 ± 9.4 kg; height: 181 ± 6 cm; experience in resistance training: 6.3 ± 2.4 years; relative bench press one-repetition maximum (1RM) 1.54 ± 0.2 kg/body mass) performed four experimental sessions consisting of a single set of the bench press at 80%1RM until mean barbell velocity dropped by 10% as the conditioning activity (CA) with a (1) standard, (2) cambered, (3) and reversed cambered barbell or a control condition in which the participants did not perform any CA. To assess the PAPE effect, single-sets of 2 repetitions of the bench press throw at 30%1RM were performed before and after the CA at the following time points: 2, 4, 6, 8, 10 min.

Results
The two-way ANOVA (4 conditions × 2time points) showed a significant interaction for peak power (p < 0.001; η2 = 0.556) and peak velocity (p = 0.001; η2 = 0.457). The standard barbell bench press CA led to the greatest performance enhancement in peak power (p = 0.001; ES = 0.54) and in peak velocity (p = 0.002; ES = 0.71) within the examined conditions.

Conclusions
The results of this study indicate that the range of motion of the CA has a significant impact on the magnitude of the PAPE response, and the greatest effect can be reached when the range of motion of the CA and the subsequent explosive task is similar.
Electronic nose homogeneous data sets for beef quality classification and microbial population prediction
Authors: Wijaya Dedy Rahman , Sarno Riyanarto , Zulaika Enny , Afianti Farah 
Published: July 2022

Abstract
Objectives
In recent years, research on the use of electronic noses (e-nose) has developed rapidly, especially in the medical and food fields. Typically, e-nose is coupled with machine learning algorithms to detect or predict multiple sensory classes in a given sample. In many cases, comprehensive and complete experiments are required to ensure the generalizability of the predictive model. For this reason, homogeneous data sets are important to use. Homogeneous data sets refer to the data sets obtained from different observations in almost similar environmental condition. In this data article, e-nose homogeneous data sets are provided for beef quality classification and microbial population prediction.

Data description
This data set is originated from 12 type of beef cuts. The process of beef spoilage is recorded using 11 Metal-Oxide Semiconductor (MOS) gas sensors for 2220 min. The formal standards, issued by the Meat Standards Committee, are used as a reference in labeling beef quality. Based on the number of microbial populations, meat quality was grouped into four classes, namely excellent, good, acceptable, and spoiled. The data set is formatted in "xlsx" file. Each sheet represents one beef cut. Moreover, data sets are good cases for feature selection algorithm stability test, especially to solve sensor array optimization problems.
Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report
Authors: Arabadjief Melissa A. , Elsayed Omar H. , Bashir Sabina , Gundumalla Meenakshi R. , Menefee Derek S. , Bergman Cody L. , Moulana Nayeem Z. , El-Mallakh Rif S. 
Published: July 2022

Abstract
Background
Ethanol dependence is associated with a discontinuation withdrawal delirium. Chlordiazepoxide is frequently successfully used in its treatment.

Case presentation
A 27-year-old, Caucasian female with ethanol dependence who had objective symptoms of withdrawal experienced worsening of her delirium after administration of chlordiazepoxide, but improved with lorazepam and cleared with discontinuation of benzodiazepine administration.

Conclusions
Worsening of delirium appears to be related to the specific use of chlordiazepoxide, but the mechanism of this effect is not clear. While this case does not alter the standard care of ethanol dependence, it does alert clinicians that our treatment approach may not be fully benign.
Tongxinluo-pretreated mesenchymal stem cells facilitate cardiac repair via exosomal transfer of miR-146a-5p targeting IRAK1/NF-κB p65 pathway
Authors: Xiong Yuyan , Tang Ruijie , Xu Junyan , Jiang Wenyang , Gong Zhaoting , Zhang Lili , Ning Yu , Huang Peisen , Xu Jun , Chen Guihao , Li Xiaosong , Hu Mengjin , Xu Jing , Wu Chunxiao , Jin Chen , Li Xiangdong , Qian Haiyan , Yang Yuejin 
Published: July 2022

Abstract
Background
Bone marrow cells (BMCs), especially mesenchymal stem cells (MSCs), have shown attractive application prospects in acute myocardial infarction (AMI). However, the weak efficacy becomes their main limitation in clinical translation. Based on the anti-inflammation and anti-apoptosis effects of a Chinese medicine-Tongxinluo (TXL), we aimed to explore the effects of TXL-pretreated MSCs (MSCsTXL) in enhancing cardiac repair and further investigated the underlying mechanism.

Methods
MSCsTXL or MSCs and the derived exosomes (MSCsTXL-exo or MSCs-exo) were collected and injected into the infarct zone of rat hearts. In vivo, the anti-apoptotic and anti-inflammation effects, and cardiac functional and histological recovery were evaluated. In vitro, the apoptosis was evaluated by western blotting and flow cytometry. miRNA sequencing was utilized to identify the significant differentially expressed miRNAs between MSCsTXL-exo and MSCs-exo, and the miRNA mimics and inhibitors were applied to explore the specific mechanism.

Results
Compared to MSCs, MSCsTXL enhanced cardiac repair with reduced cardiomyocytes apoptosis and inflammation at the early stage of AMI and significantly improved left ventricular ejection fraction (LVEF) with reduced infarct size in an exosome-dependent way. Similarly, MSCsTXL-exo exerted superior therapeutic effects in anti-apoptosis and anti-inflammation, as well as improving LVEF and reducing infarct size compared to MSCs-exo. Further exosomal miRNA analysis demonstrated that miR-146a-5p was the candidate effector of the superior effects of MSCsTXL-exo. Besides, miR-146a-5p targeted and decreased IRAK1, which inhibited the nuclear translocation of NF-κB p65 thus protecting H9C2 cells from hypoxia injury.

Conclusions
This study suggested that MSCsTXL markedly facilitated cardiac repair via a new mechanism of the exosomal transfer of miR-146a-5p targeting IRAK1/NF-κB p65 pathway, which has great potential for clinical translation.
One Health—One Biofilm
Authors: Jacques Mario , Malouin François 
Published: July 2022

AbstractBacterial biofilms are structured clusters of bacterial cells enclosed in a self-produced polymer matrix that are attached to a biotic or abiotic surface. This structure protects bacteria from hostile environmental conditions. There are also accumulating reports about bacterial aggregates associated but not directly adherent to surfaces. Interestingly, these bacterial aggregates exhibit many of the same phenotypes as surface-attached biofilms. Surface-attached biofilms as well as non-attached aggregates are ubiquitous and found in a wide variety of natural and clinical settings. This strongly suggests that biofilm/aggregate formation is important at some steps in the bacterial lifecycle. Biofilm/aggregate formation might therefore be important for some bacterial species for persistence within their host or their environment, while for other bacterial species it might be more important for persistence in the environment between infection of different individuals or even between infection of different hosts (humans or animals). This is strikingly similar to the One Health concept which recognizes that the health and well-being of humans, animals and the environment are intricately linked. We would like to propose that within this One Health concept, the One Biofilm concept also exists, where biofilm/aggregate formation in humans, animals and the environment are also intricately linked. Biofilm/aggregates could represent the unifying factor underneath the One Health concept. The One Biofilm concept would support that biofilm/aggregate formation might be important for persistence during infection but might as well be even more important for persistence in the environment and for transmission between different individuals/different hosts.
Masked multi-center angular margin loss for language recognition
Authors: Ju Minghang , Xu Yanyan , Ke Dengfeng , Su Kaile 
Published: July 2022

AbstractLanguage recognition based on embedding aims to maximize inter-class variance and minimize intra-class variance. Previous researches are limited to the training constraint of a single centroid, which cannot accurately describe the overall geometric characteristics of the embedding space. In this paper, we propose a novel masked multi-center angular margin (MMAM) loss method from the perspective of multiple centroids, resulting in a better overall performance. Specifically, numerous global centers are used to jointly approximate entities of each class. To capture the local neighbor relationship effectively, a small number of centers are adapted to construct the similarity relationship between these centers and each entity. Furthermore, we use a new reverse label propagation algorithm to adjust neighbor relations according to the ground truth labels to learn a discriminative metric space in the classification process. Finally, an additive angular margin is added, which understands more discriminative language embeddings by simultaneously enhancing intra-class compactness and inter-class discrepancy. Experiments are conducted on the APSIPA 2017 Oriental Language Recognition (AP17-OLR) corpus. We compare the proposed MMAM method with seven state-of-the-art baselines and verify that our method has 26.2% and 31.3% relative improvements in the equal error rate (EER) and Cavg respectively in the full-length test (“full-length” means the average duration of the utterances is longer than 5 s). Also, there are 31.2% and 29.3% relative improvements in the 3-s test and 14% and 14.8% relative improvements in the 1-s test.
Virtual classes during COVID-19 pandemic: focus on university students’ affection, perceptions, and problems in the light of resiliency and self-image
Authors: Assi Elham , Rashtchi Mojgan 
Published: July 2022

AbstractAlthough online learning has been studied extensively over the last two decades, students’ feedback toward such classes during the COVID-19 pandemic seems essential due to their effects on the education systems. The present exploratory sequential mixed methods study aimed to address university students’ affection, perception, and problems in online courses during the pandemic considering their resiliency and self-image. A 37-item virtual class Affection Perceptions, Problems, Resiliency, and Self-image Questionnaire (APPRSQ) was developed, validated, and administered online to 252 university Translation and TEFL-major students. The results demonstrated that the APPRSQ is a valid and reliable data gathering instrument. The participants’ answers to APPRSQ indicated that they were resilient and could adapt to the new learning mode. However, they preferred face-to-face classes, though they believed online courses were inevitable during the pandemic. Such courses had some advantages, such as enhancing students’ technological knowledge and helping them become autonomous. The triangulated data obtained from interviews with 20 students were analyzed. The results could provide a further understanding of APPRSQ factors. The study suggests that teachers and educational authorities improve the quality of online classes.