bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of HDL-C/LDL-C with myocardial infarction, all-cause mortality, haemorrhagic stroke and ischaemic stroke: a longitudinal study based on 384 093 participants from the UK Biobank
Authors: Yuan Shiqi , Huang Xiaxuan , Ma Wen , Yang Rui , Xu Fengshuo , Han Didi , Huang Tao , Peng MIn , Xu Anding , Lyu Jun 
Published: September 2022

ObjectiveTo explore the correlations of high-density lipoprotein cholesterol (HDL-C)/low-density lipoprotein cholesterol (LDL-C) with myocardial infarction (MI), all-cause mortality, haemorrhagic stroke and ischaemic stroke, as well as the joint association of genetic susceptibility and HDL-C/LDL-C with the MI risk.Methods and resultsThis study selected 384 093 participants from the UK Biobank (UKB) database. First, restricted cubic splines indicated non-linear associations of HDL-C/LDL-C with MI, ischaemic stroke and all-cause mortality. Second, a Cox proportional-hazards model indicated that compared with HDL-C/LDL-C=0.4–0.6, HDL-C/LDL-C<0.4 and >0.6 were correlated with all-cause mortality (HR=0.97 for HDL-C/LDL-C<0.4, 95% CI=0.939 to 0.999, p<0.05; HR=1.21 for HDL-C/LDL-C>0.6, 95% CI=1.16 to 1.26, p<0.001) after full multivariable adjustment. HDL-C/LDL-C<0.4 was correlated with a higher MI risk (HR=1.36, 95% CI=1.28 to 1.44, p<0.05) and ischaemic stroke (HR=1.12, 95% CI=1.02 to 1.22, p<0.05) after full multivariable adjustment. HDL-C/LDL-C>0.6 was associated with higher risk haemorrhagic stroke risk after full multivariable adjustment (HR=1.25, 95% CI=1.03 to 1.52, p<0.05). Third, after calculating the coronary heart disease Genetic Risk Score (CHD-GRS) of each participant, the Cox proportional-hazards model indicated that compared with low CHD-GRS and HDL-C/LDL-C=0.4–0.6, participants with a combination of high CHD-GRS and HDL-C/LDL-C<0.4 were associated with the highest MI risk (HR=2.45, 95% CI=2.15 to 2.8, p<0.001). Participants with HDL-C/LDL-C<0.4 were correlated with a higher MI risk regardless of whether they had a high, intermediate or low CHD-GRS.ConclusionIn UKB participants, HDL-C/LDL-C ratio of 0.4–0.6 was correlated with lower MI risk, all-cause mortality, haemorrhagic stroke and ischaemic stroke. Participants with HDL-C/LDL-C<0.4 were correlated with a higher MI risk regardless of whether they had a high, intermediate or low CHD-GRS. The clinical significance and impact of HDL-C/LDL-C need to be further verified in future studies.
A decision support tool for forwarding operations with sequence-dependent loading
Authors: Hansson Linnea J. , Forsmark Victoria , Flisberg Patrik , Rönnqvist Mikael , Mörk Anders , Jönsson Petrus 
Published: September 2022

High productivity in forest harvesting requires efficient forwarding. Planning is complicated by multiple choices of routes and their order, the number and types of assortments, the loading sequence, and pile organization at the landing. This paper develops and tests a decision support tool for forwarder routing with sequential co-loading of assortments. Input data are the harvester production file (including Global Navigation Satellite Systems tracking), placement of landing, and machine specifications. The trail network is generated from the harvester production data when devising routes to pick up all log piles, including specific assortments and volumes. Multiple assortments can be loaded along each route, and a certain loading sequence of assortments is preferred and (or) required. Sorting time during co-loading varies, depending on the assortment combinations and bunk loading pattern. Route planning is modeled using a set-partitioning problem, and the solution method is a metaheuristic based on repeated matching. In addition to routes and loading sequences, solutions include the organization of assortment piles at the landing, depending on the total volume of each assortment. The tool produces similar results to those attained by skilled forwarder operators on five clearcuts (3–11 ha) in northern Sweden, when the results are compared with data from actual forwarder production files.
Decreased Na+/K+ pump activity in the erythrocyte membrane due to malondialdehyde in rheumatoid arthritis: an in vivo and in silico study
Authors: Oğul Yasemin , Gür Fatma , Gür Bahri , Cengiz Mustafa , Sarı Refik Ali , Kızıltunç Ahmet 
Published: September 2022

Apart from demonstrating the interaction behavior of malondialdehyde (MDA) with Na+/K+-ATPase using in silico, the current study aims to investigate the effect of rheumatoid arthritis-related oxidative stress on Na+/K+-ATPase activity that is present in the erythrocyte cell membrane, which is rich in proteins vulnerable to damage from MDA and other free radicals. The target population of this study consists of 28 rheumatoid arthritis patients and 20 healthy volunteers whose MDA levels and Na+/K+-ATPase activity were determined. It was shown that MDA levels of rheumatoid arthritis patients increased ( p < 0.001) and their Na+/K+-ATPase activity noticeably decreased when compared to those of healthy individuals. Also, according to this in silico modeling, MDA decreased Na+/K+-ATPase activity in line with the correlation analyses. Consequently, while elevated levels of MDA in the rheumatoid arthritis group were suggestive of oxidative stress, a decreased Na+/K+-ATPase-activity led us to speculate that the cellular membrane had sustained injury. Therefore, our results could be useful in explaining how MDA affects Na+/K+-ATPase activity in the interior of a specific molecular pathway.
Virtual Time III, Part 1: Unified Virtual Time Synchronization for Parallel Discrete Event Simulation
Authors: Jefferson David R. , Barnes Peter 
Published: September 2022

Algorithms for synchronization of parallel discrete event simulation have historically been divided between
conservative
methods that require lookahead but not rollback, and
optimistic
methods that require rollback but not lookahead. In this paper we present a new approach in the form of a framework called

Unified Virtual Time
(UVT)

that unifies the two approaches, combining the advantages of both within a single synchronization theory. Whenever timely lookahead information is available, a
logical process (LP)
executes conservatively using an
irreversible
event handler. When lookahead information is not available the LP does not block, as it would in a classical conservative execution, but instead executes optimistically using a
reversible
event handler. The switch from conservative to optimistic synchronization and back is decided on an event-by-event basis by the simulator, transparently to the model code. UVT treats conservative synchronization algorithms as optional accelerators for an underlying optimistic synchronization algorithm, enabling the speed of conservative execution whenever it is applicable, but otherwise falling back on the generality of optimistic execution.

We describe UVT in a novel way, based on fundamental invariants, monotonicity requirements, and synchronization rules. UVT permits zero-delay messages and pays careful attention to tie-handling using superposition. We prove that under fairly general conditions a UVT simulation always makes progress in virtual time.
This is Part 1 of a trio of papers describing the UVT framework for PDES, mixing conservative and optimistic synchronization and integrating throttling control.
Time-Aware Anonymization of Knowledge Graphs
Authors: Hoang Anh-Tu , Carminati Barbara , Ferrari Elena 
Published: September 2022

Knowledge graphs (KGs) play an essential role in data sharing because they can model both users’ attributes and their relationships. KGs can tailor many data analyses, such as classification where a sensitive attribute is selected and the analyst analyzes the associations between users and the sensitive attribute’s values (aka sensitive values). Data providers anonymize their KGs and share the anonymized versions to protect users’ privacy. Unfortunately, an adversary can exploit these attributes and relationships to infer sensitive information by monitoring either one or many snapshots of a KG. To cope with this issue, in this paper, we introduce (
k
,
l
)-Sequential Attribute Degree ((
k
,
l
)-sad), an extension of the

k
w

-tad principle[10], to ensure that sensitive values of re-identified users are diverse enough to prevent them from being inferred with a confidence higher than

\(\frac{1}{l} \)

even though adversaries monitor all published KGs. In addition, we develop the Time-Aware Knowledge Graph Anonymization Algorithm to anonymize KGs such that all published anonymized versions of a KG satisfy the (
k
,
l
)-sad principle, by, at the same time, preserving the utility of the anonymized data. We conduct experiments on four real-life datasets to show the effectiveness of our proposal and compare it with

k
w

-tad.
Diet composition of the deep-water rose shrimp, Parapenaeus longirostris (Decapoda, Dendrobranchiata, Penaeidae), from the Algerian west coast
Authors: Kerfouf Ahmed , De los Ríos-Escalante Patricio R. , Esse Carlos 
Published: September 2022

Abstract
The deep-water rose shrimp, Parapenaeus longirostris (H. Lucas, 1846), is the most dominant shrimp species on the Algerian west coast. In that area, the diet of P. longirostris was studied between July 2020 and June 2021. This approach to the diet of the rose shrimp was based on analysis of the stomach contents and determination of the ingested prey. A seasonal sampling was carried out in the main fishing ports (Béni Saf, Bouzedjar, Oran and Mostaganem). The results obtained showed that the shrimp feed intensively in spring and increasingly less in winter and summer. Crustaceans, foraminiferans, polychaetes, and molluscs constituted the most frequent preys in the diet, with respective frequencies of 58.85, 55.95, 36.63 and 32.04%. Small microplancton and mesoplancton prey (radiolarians, copepods, and various larvae) were less important in the diet of P. longirostris. Fish and echinoderms constitute accidental prey, of which the frequency is less than 10%.
Redescription of Orbitacolax bispinus Izawa, 2021 (Copepoda, Cyclopoida, Bomolochidae), with descriptions of the male, copepodid V female, and copepodid IV sex undetermined
Authors: Izawa Kunihiko 
Published: September 2022

Abstract
Orbitacolax bispinus Izawa, 2021 is redescribed based on specimens of both sexes of the adult, copepodid V female, and copepodid IV sex undetermined, which were all recovered together with those of O. leptoscari (Yamaguti, 1953) from under the scales of Pseudolabrus sieboldi Mabuchi & Nakabo, 1997 (Pisces, Perciformes, Labridae) in Japan. Descriptions of the male and copepodid V female are the first time for the species.
Proteases from Penaeus monodon Fabricius, 1798 (Decapoda, Penaeidae): partial characterization and localization
Authors: Nguyen Hong-Loan T. , Quach Hong-Thai , Trinh Dinh-Quynh , Nguyen Huong-Quynh , Pham Bao-Yen , Dinh Thai-Nho , Ngo Thi-Trang , Phan Tuan-Nghia 
Published: September 2022

Abstract
This study aimed to characterize and determine the distribution of proteases in various anatomical parts of Penaeus monodon using mainly electrophoresis on sodium dodecyl sulfate (SDS) polyacrylamide gels impregnated with casein (casein-SDS-PAGE) and specific protease inhibitors. Twelve caseinolytic bands designated A-L, with estimated molecular masses of 11.4-49.6 kDa were detected by SDS-PAGE, and were most abundant in the hepatopancreas. Among the 12 bands, E, J, K and L were predominant, A, G and H were identified as chymotrypsin-like proteases, D, E, I, J, K and L were identified as trypsin-like proteases, and B, C and F were identified as serine proteases. The proteases were most active at 50°C and pH 7.0. The proteolytic and trypsin-like activities of Penaeus monodon were most abundant in hepatopancreas extracts and least abundant in extracts from the haemolymph. Trypsin-like proteases in the hepatopancreas extract were found to activate prophenoloxidase (proPO) to form phenoloxidase (PO).
Comparison of the sensitivities of crustacean species to recombinant Photorhabdus insect-related (Pir) toxins of acute hepatopancreatic necrosis disease-causing Vibrio parahaemolyticus
Authors: Kim Ji Seok , Jang In-Kwon , Lee Miyoung , Kim Suhyun , Uhm Taewoong , Yi Seongbaek , Choi Tae-Jin 
Published: September 2022

Abstract
Photorhabdus insect-related PirAvp (where vp stands for Vibrio parahaemolyticus) and PirBvp of Vibrio parahaemolyticus were expressed in Escherichia coli, designated rPirAvp and rPirBvp, respectively, then tested on 4 crustaceans via immersion tests. PirBvp toxin was detected from 2 h after incubation and accumulated with bacterial growth. The culture filtrate of 15 nM PirBvp toxin caused 100% mortality of Litopenaeus vannamei within 4 days after immersion. Litopenaeus vannamei showed 100% mortality at 7 days after immersion in purified 4 nM rPirAvp, rPirBvp, or rPirAvp + rPirBvp mixture. The cumulative mortalities in the rPirAvp, rPirBvp or rPirAvp + rPirBvp mixture were 50, 83 and 100% in Macrobrachium rosenbergii after 12 days of immersion, 11, 77 and 100% in Palaemon paucidens after 10 days of immersion, and 36, 96 and 100% in Macrophthalmus japonicus after 6 days of immersion, respectively.
Exhibiting Transnationalism after Vietnam: The Alpha Gallery’s Vision of an Artistic Renaissance in Southeast Asia
Authors: Ngoei Wen-Qing 
Published: September 2022

Abstract
This essay examines the Alpha Gallery, an independent artists’ cooperative that Malaysians and Singaporeans established, which staged art shows during the 1970s to spark an artistic renaissance in Southeast Asia. The cooperative’s transnational vision involved showcasing Balinese folk art as a primitive and, therefore, intrinsically Southeast Asian aesthetic, while asserting that it shared cultural connections with the Bengali Renaissance of the early 20th Century. Alpha’s leaders believed these actions might awaken indigenous artistic traditions across Southeast Asia. Their project underscores the lasting cultural impact of colonialism on Southeast Asia and the contested character of the region. Alpha’s condescending view of Balinese folk art echoed the paternalism of Euro-American colonial discourses about civilizing indigenous peoples that persisted because its key members received much of their education or training in Britain and the United States, a by-product of their countries’ pro-U.S. trajectory during the Vietnam War. Equally, Alpha’s transnationalism ran counter to Southeast Asian political elites’ fixation with pressing art toward nation-building. Indeed, the coalescing of nation-states does not define the region’s history during and after the Vietnam War. Rather, non-state actors like Alpha’s members, in imagining and pursuing their versions of Southeast Asia, contributed to the persistent contingency of the region.
Sustenance and Survival
Authors: Joseph O’Neil 
Published: September 2022

Abstract
This article explores women’s engagement with food production and distribution in Tobago from 1840 to 1940. Scholars such as Raymond Smith have suggested that freedom in the British West Indies meant “the withdrawal of female labor from plantation work.” In Tobago, while women fled the estates, they did not abandon working the land. In fact, working the land and selling food was critical to the sustenance and survival of women and their families. Among Afro-Tobagonian women, food became a tool of power and empowerment. Through the production and sale of food, Afro-Tobagonian women asserted control over resources, steered the economic empowerment of their families, and crafted identities as autonomous beings. This article, undergirded by archival documents and oral testimonies, refines our understanding of women’s mobility and labor experiences in Tobago, and by extension, the Caribbean.
Understanding efl Teachers’ Emotional Experience of Doing Research: A Review
Authors: Li Fei , Jiang Lianjiang 
Published: September 2022

Abstract
In an era when scientific research is in the spotlight, foreign language teachers have developed a variety of complex and diverse emotions towards it. Research into teachers’ professional development has long focused on rational factors. However, teacher emotions are real and emotions are at the heart of teaching and learning. Teachers’ research emotions are therefore as important as the rational elements of teacher professional development. Indeed, teacher emotions have a crucial impact on teachers’ careers and development, and teacher emotions cannot be ignored. However, little attention has been paid to research on English teachers’ emotions, and there is a lack of literature reviews to sort out the limited research on English teachers’ emotions. Such a literature review would help to understand the gaps in the current field of research on English teachers’ research on emotions and thus better guide the direction of future research. By using keywords to identify relevant studies, further screening and analysing candidate studies, and reporting and summarizing existing research findings, this study reviews the current state of research on English teachers’ research on emotional experiences and finds that research on foreign language teachers’ emotions is mainly concerned with the content of emotional experiences, emotion formation and its influencing factors. On this basis, further directions for research are indicated, including the attention paying to the processes of emotion formation and emotion adjustment strategies of foreign language teachers, the emotions of university teachers and the influence of Chinese society and culture on foreign language teachers in higher education.
Intertextual Links between Isaiah 59 and the Armour of God in Ephesians 6
Authors: Carter Tim 
Published: September 2022

Abstract
Believers are told in Ephesians 6:11 to put on God’s armour. In Isaiah 59:17, God himself puts on the breastplate of righteousness and the helmet of salvation to come and fight for his people, and these are among the qualities identified as missing in the indictment against God’s people in Isaiah 59:8–15. The article identifies other intertextual allusions to Isaiah in the other four items of armour, and explores the extent to which the other qualities represented by the pieces of equipment also draw on the description of the nation’s plight in Isaiah 59. An awareness of these intertextual allusions suggests that putting on God’s armour means enlisting in the spiritual struggle and going on the offensive by adopting a lifestyle marked by the qualities listed in Ephesians 6:14–17.
Circulation and Soil Moisture Contributions to Heatwaves in the United States
Authors: Horowitz Russell L. , McKinnon Karen A. , Simpson Isla R. 
Published: September 2022

Abstract
Extreme heat events are a threat to human health, productivity, and food supply, so understanding their drivers is critical to adaptation and resilience. Anticyclonic circulation and certain quasi-stationary Rossby wave patterns are well known to coincide with heatwaves, and soil moisture deficits amplify extreme heat in some regions. However, the relative roles of these two factors in causing heatwaves is still unclear. Here we use constructed circulation analogs to estimate the contribution of atmospheric circulation to heatwaves in the United States in the Community Earth System Model version 1 (CESM1) preindustrial control simulations. After accounting for the component of the heatwaves explained by circulation, we explore the relationship between the residual temperature anomalies and soil moisture. We find that circulation explains over 85% of heatwave temperature anomalies in the eastern and western United States but only 75%–85% in the central United States. In this region, there is a significant negative correlation between soil moisture the week before the heatwave and the strength of the heatwave that explains additional variance. Further, for the hottest central U.S. heatwaves, positive temperature anomalies and negative soil moisture anomalies are evident over a month before heatwave onset. These results provide evidence that positive land–atmosphere feedbacks may be amplifying heatwaves in the central United States and demonstrate the geographic heterogeneity in the relative importance of the land and atmosphere for heatwave development. Analysis of future circulation and soil moisture in the CESM1 Large Ensemble indicates that, over parts of the United States, both may be trending toward greater heatwave likelihood.
Nonlocal Impacts of Soil Moisture Variability in South America: Linking Two Land–Atmosphere Coupling Hot Spots
Authors: Giles Julián Alberto , Menéndez Claudio Guillermo , Ruscica Romina Carla 
Published: September 2022

Abstract
The land–atmosphere interactions play an important role in modulating climate variability at different spatial and temporal scales. In South America, two recognized hot spots of soil moisture–atmosphere coupling are located in southeastern South America (SESA) and eastern Brazil. Soil moisture variability may not only alter the climate locally but may also have nonlocal impacts through changes in the regional circulation. Here we explore how these two local coupling hot spots interact with each other, how soil moisture variability modulates the regional circulation, and what is the consequent nonlocal impact on precipitation. To this end, we analyze numerical experiments, performed with a regional climate model for the period October–March of 1983–2012, that allow us to isolate the influence of the soil moisture interannual variability on the regional climate. When the soil moisture–atmosphere interaction is enabled, we find a nonlocal coupling mechanism that links both hot spots at different temporal scales, favoring precipitation in eastern Brazil to the detriment of the precipitation in SESA through shifts in the regional circulation, when compared with a simulation with constrained soil moisture–atmosphere interaction. In northeastern Argentina, a subregion of SESA located at the exit of the South American low-level jet, it was found that the amount of nighttime precipitation is modulated by the proposed nonlocal coupling mechanism. A better understanding of the variability of precipitation due to the influence of land–atmosphere interaction processes may contribute to improving the predictability of precipitation and the interpretation of climate projections.