bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Covalent Chemistry for Synthesis and Co‐conformational Control of Mechanically Interlocked Molecules
Authors: Yu Jingjing , Gaedke Marius , Schaufelberger Fredrik 
Published: November 2022

AbstractMechanically interlocked molecules have found extensive applications in areas all across the physical sciences, from materials to catalysis and sensing. However, introducing mechanical bonds and entanglements at the molecular level is still a significant challenge due to the inherent restriction in entropy needed to preorganize strands before interlocking. Over the last decade, dynamic covalent chemistry has emerged as one of the most efficient methods of forming rotaxanes, catenanes and molecular knots. By using reversible bonds such as imines, disulfides and boronate esters, one can use the inherent error‐correction in these linkages to form interlocked architectures with high fidelity and often in excellent yields. This review reports on recent advances in the use of dynamic covalent chemistry to make mechanically interlocked molecules, systematically surveying clipping, capping and templating approaches with dynamic bonds. Furthermore, it is also discussed how dynamic bonds can be used to control motion, co‐conformational expression and catalytic activity in mechanically interlocked molecular machinery.
The authoritarian dynamic and Brexit: Understanding the relationship between authoritarianism and wanting to leave the EU
Authors: Stevens Daniel , Banducci Susan 
Published: November 2022

AbstractIndividual‐level authoritarianism is prominent in explanations of preferences for Brexit. We contend that extant accounts have provided an incomplete theoretical and empirical understanding of this relationship. Drawing on the idea of the ‘authoritarian dynamic’, we show that perceptions of the economic/cultural threat of immigration have stronger effects on the pro‐Brexit views of individuals with weak authoritarian predispositions (libertarians). At the same time, perceptions of normative threat, which pertain to concerns like loss of faith in or lack of consensus among established authorities, have a greater impact on the pro‐Brexit views of individuals with high authoritarian predispositions (authoritarians). These conditional relationships, which have previously gone unacknowledged, are crucial to understanding which individuals are likely to respond to ‘increased threat’ with pro‐Brexit attitudes. We demonstrate these relationships with pro‐Brexit views using British Election Study longitudinal panel data. The results clarify the conditional impact of threats and authoritarian predispositions on attitudes.
Determination of Diaryliodonium Species by Reverse Iodometric Titration with Ascorbic Acid
Authors: Buriánek Jan D. , Kvicala Jaroslav , Sekerova Lada , Müller Bernd H. , Francke Robert , Bystron Tomas 
Published: November 2022

AbstractDiaryliodonium salts are used in organic chemistry, materials science and pharmaceutical chemistry. For the quantitative analysis of diaryliodonium salts, only instrumentally demanding techniques requiring highly skilled operators are available. Surprisingly, no titration method taking advantage of the oxidising ability of diaryliodonium is available in the literature. In the present work, a titration method for the determination of diaryliodonium salts is presented. It is based on the reaction of diaryliodonium species with ascorbic acid, whose excess is subsequently determined by means of iodometric potentiometric titration. Application of the protocol to various diaryliodonium salts revealed the scope and limitations of the method.
An innovative technology of fracturing hard strata from the ground for precontrol of rock burst in a coal mine
Authors: Tai Yang , Yu Bin , Kuang Tiejun , Shi Bowen , Meng Xiangbin , Fu Maoquan 
Published: November 2022

AbstractRock bursts are one of the most common dynamic disasters in coal mines and seriously affect safety production. At present, there are three common types of rock bursts: fault‐structure, fold‐structure, and thick/hard‐roof rock bursts. First, the paper proposed an innovative technology for mine ground fracturing to control those rock bursts. Then, for the new method, its fracturing devices, process, and monitoring technique for cracks were introduced. Next, we analyzed the detailed control procedures for those types of rock bursts and control principles of absorbing energy, blocking stress transmission, and reducing overall rock strength. To illustrate the control effect of ground fracturing for the rock bursts, we proposed a Voronoi block division method (VBDM) and multistrength criteria (MSC) consisting of Mohr–Coulomb Joint, Hoek–Brown Joint, and strain–stress equivalent method. Then, two numerical models using the VBDM and MSC were established. One is fault‐structure rock burst with ground fracturing and another is that without. From the numerical simulation, it was concluded that: (1) The ground fracturing will increase τ/σn, a ratio of shear stress to the normal stress of the fault, from 0.25 to 0.50, especially within 100 m of a working face to a fault. This situation indicates that ground fracturing will induce fault slip in advance, thus releasing energy in advance. (2) Fractured zones with low stress were formed by ground fracturing, which can reduce both upward extrusion pressure and normal stress, thereby triggering the fault slippage in advance. The energy released from the fault can be absorbed by the fractured zone, thereby controlling the advanced stress of the working face, and lowering the danger of rock burst.
Adaptive Bayesian variable clustering via structural learning of breast cancer data
Authors: Ghosh Riddhi Pratim , Maity Arnab K. , Pourahmadi Mohsen , Mallick Bani K. 
Published: November 2022

AbstractThe clustering of proteins is of interest in cancer cell biology. This article proposes a hierarchical Bayesian model for protein (variable) clustering hinging on correlation structure. Starting from a multivariate normal likelihood, we enforce the clustering through prior modeling using angle‐based unconstrained reparameterization of correlations and assume a truncated Poisson distribution (to penalize a large number of clusters) as prior on the number of clusters. The posterior distributions of the parameters are not in explicit form and we use a reversible jump Markov chain Monte Carlo based technique is used to simulate the parameters from the posteriors. The end products of the proposed method are estimated cluster configuration of the proteins (variables) along with the number of clusters. The Bayesian method is flexible enough to cluster the proteins as well as estimate the number of clusters. The performance of the proposed method has been substantiated with extensive simulation studies and one protein expression data with a hereditary disposition in breast cancer where the proteins are coming from different pathways.
Exposure in utero to adverse events and health late‐in‐life: Evidence from China
Authors: Wang Jiyuan , Alessie Rob , Angelini Viola 
Published: November 2022

AbstractThis paper estimates the effect of in utero exposure to adverse events on late life diabetes, cardiovascular disease risks and cognition deficiency. We merge data on the regional violence during the Cultural Revolution and the excessive death rates during the Chinese Great Famine with data from the China Health and Retirement Longitudinal Study survey. Results show that female babies who were exposed in utero to the famine have higher diabetes risks, while male babies who were exposed to the Cultural Revolution are shown to have lower cognitive abilities.
Uterine contraction may not be an independent risk factor for spontaneous preterm birth before 35 weeks in women with cervical shortening
Authors: Horie Kenji , Takahashi Kayo , Mieno Makiko , Nagayama Shiho , Aoki Hiroaki , Nagamatsu Takeshi , Kanatani Ayumi , Hyodo Hironobu , Terada Kayoko , Hayashi Masako , Nakai Akihito , Yoneda Noriko , Saito Shigeru , Matsuda Yoshio , Matsubara Shigeki , Ohkuchi Akihide ,   Japanese Organization of Prevention of Preterm Delivery*
Published: November 2022

AbstractObjectiveTo compare the risk of spontaneous preterm birth (SPTB) before 35 weeks in symptomatic and asymptomatic women with cervical shortening at 16–34 weeks under mid‐trimester universal screening of cervical length (CL).MethodMulticenter retrospective cohort study involving six secondary/tertiary perinatal centers was planned in 2016. Primary outcomes were SPTB before 35 weeks. In all, 407 women were analyzed using multivariable logistic regression analysis for predicting SPTB before 35 weeks while adjusting for presence/absence of uterine contraction, gestational weeks, vaginal bleeding, and CL classification (1–9, 10–14, 15–19, and 20–24 mm) at admission, the execution of cervical cerclage, and the presence/absence of past history of preterm delivery.ResultsSPTB before 35 weeks of pregnancy occurred in 14.5%. Presence of uterine contraction was not an independent risk factor for SPTB before 35 weeks (adjusted odds ratio [aOR] 1.22, 95% confidence interval [CI] 0.67–2.20). CL of 1–9 mm, CL of 10–14 mm, and vaginal bleeding at admission were independent risk factors for SPTB before 35 weeks (aOR 5.35, 95% CI 2.11–13.6; aOR 2.79, 95% CI 1.12–6.98; and aOR 2.37, 95% CI 1.12–5.10, respectively).ConclusionIn women with a cervical shortening at 16–34 weeks, presence of uterine contractions at admission may not be an independent risk factor for the occurrence of SPTB before 35 weeks.
Efficacy and safety of epidural clonidine by continuous infusion or patient‐controlled analgesia in labor: A meta‐analysis of randomized controlled trials
Authors: Xia Feng , Wang Li‐Zhong , Chang Xiang‐Yang , Zhang Yin‐Fa 
Published: November 2022

AbstractBackgroundEpidural clonidine improves analgesia but may induce adverse effects in labor.ObjectiveTo evaluate the efficacy and safety of epidural clonidine as local anesthetics (LA) adjuvant by continuous infusion or patient‐controlled epidural analgesia (PCEA) in labor.Search StrategyPubMed, Embase, Web of Science, and CENTRAL were searched from inception to May 10, 2022 without language restriction; references of the retrieved studies were hand searched.Selection CriteriaRandomized controlled trials (RCTs) comparing epidural LA with and without clonidine using continuous infusion or PCEA in labor were included.Data Collection and AnalysisA random effects model was used to pool the data on analgesia and adverse effects.Main ResultsEight RCTs were included. Clonidine did not reduce the incidence of parturients requiring additional epidural boluses but reduced LA consumption and pain scores without increasing adverse effects, except for a higher incidence of instrumental delivery when clonidine was combined with LA and opioid (risk ratio 2.38, 95% confidence interval 1.26–4.50). Clonidine offered similar analgesia to opioids but had reduced opioid‐related adverse effects. Trial sequential analysis showed that the evidence was insufficient.ConclusionsEpidural clonidine by continuous infusion or PCEA does not increase significant adverse effects and offers similar analgesia to opioids in labor. PROSPERO registration no. CRD42022306565.
Deep self‐supervised transformation learning for leukocyte classification
Authors: Chen Xinwei , Zheng Guolin , Zhou Liwei , Li Zuoyong , Fan Haoyi 
Published: November 2022

AbstractThe scarcity of training annotation is one of the major challenges for the application of deep learning technology in medical image analysis. Recently, self‐supervised learning provides a powerful solution to alleviate this challenge by extracting useful features from a large number of unlabeled training data. In this article, we propose a simple and effective self‐supervised learning method for leukocyte classification by identifying the different transformations of leukocyte images, without requiring a large batch of negative sampling or specialized architectures. Specifically, a convolutional neural network backbone takes different transformations of leukocyte image as input for feature extraction. Then, a pretext task of self‐supervised transformation recognition on the extracted feature is conducted by a classifier, which helps the backbone learn useful representations that generalize well across different leukocyte types and datasets. In the experiment, we systematically study the effect of different transformation compositions on useful leukocyte feature extraction. Compared with five typical baselines of self‐supervised image classification, experimental results demonstrate that our method performs better in different evaluation protocols including linear evaluation, domain transfer, and finetuning, which proves the effectiveness of the proposed method.
Quantitative measurement of blood glucose influenced by multiple factors via photoacoustic technique combined with optimized wavelet neural networks
Authors: Ren Zhong , Liu Tao , Xiong Chengxin , Huang Shuanggen , Zhang Jia , Peng Wenping , Wu Junli , Liang Gaoqiang , Sun Bingheng 
Published: November 2022

AbstractIn this work, the photoacoustic (PA) quantitative measurement of blood glucose concentration (BGC) influenced by multiple factors was firstly investigated. A set of PA detection system of blood glucose considering the comprehensive influence of five factors was established. The PA signals and peak‐to‐peak values (PPVs) of 625 rabbit whole blood were obtained under 625 influence combinations. Due to the accurate measurement of BGC limited by the overlap PA signals, wavelet neural network (WNN) was utilized to train the PPVs of blood glucose for 500 rabbit blood. The mean square error (MSE) of BGC for 125 testing blood was approximately 6.5782 mmol/L. To decrease the MSE, the parameters of WNN were optimized by particle swarm optimization (PSO), that is, PSO‐WNN algorithm was employed. Under the optimal parameters, MSE of BGC was decreased to approximately 0.48005 mmol/L. To further improve the prediction accuracy of BGC, an improved nonlinear dynamic inertia weight (NDIW) strategy of PSO was proposed, and compared with other two kinds of dynamic inertia weight strategies. Under the optimal parameters, the MSE of BGC was decreased to approximately 0.2635 mmol/L. The comparison of nine algorithms demonstrate that the PA technique combined with PSO‐WNN and the improved NDIW strategy is significant in the quantitative measurement of blood glucose influenced by multiple factors.
Depletion of Tip60/Kat5 affects the hepatic antioxidant system in mice
Authors: Kocpinar Enver Fehim , Baltaci Nurdan Gonul , Akkemik Ebru , Budak Harun 
Published: November 2022

AbstractTat‐interactive protein 60 kDa (TIP60, also known as lysine acetyltransferase 5 [KAT5]) is a member of the MYST protein family with histone acetyltransferase activity. Recent studies have reported that TIP60 has multiple functions in many signal transduction mechanisms, especially p53‐mediated apoptosis. Although the activation of apoptosis signaling pathways requires the presence of cellular reactive oxygen species (ROS) at a certain level, an imbalance between the production and consumption of ROS in cells results in oxidative stress (OS). In this study, we investigated for the first time how the absence of the Tip60 gene in the liver affects gene expression, enzyme activity, and protein expression of the hepatic antioxidant members localized in the cytoplasm, including superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), and glutathione S‐transferase (GST). First, we successfully generated liver‐specific Tip60 knockout mice (mutants) using Cre/LoxP recombination. The reduced glutathione level and nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) expression, a marker of OS, increased significantly in the Tip60 mutant liver. Gene expression, activity, and protein expression of the enzymatic antioxidant system, including SOD, CAT, GR, GPx, and GST were investigated in mutants and control groups. Despite a significant correlation between the gene, enzyme activity, and protein content for CAT and GR, this was not true for SOD and GPx. The overall results suggest that TIP60 acts on the hepatic antioxidant system both at the gene and protein levels, but the actual effect of the deletion of Tip60 is observed at the protein level, especially for SOD and GPx.
Synthesis of carboxylic graphene oxide‐carboxymethyl chitosan composite and its applications toward the remediation of U6+, Pb2+, Cr6+, and Cd2+ ions from aqueous solutions
Authors: Patel Khilawan , Sutar Alekha Kumar , Maharana Tungabidya 
Published: November 2022

AbstractThe current research work deals with the synthesis of a novel composite material of carboxylic graphene oxide‐carboxymethyl chitosan (COOH‐GO‐CMC) composite by ultrasound and microwave‐assisted processes. The composite was characterized by Fourier Transform Infra‐red spectroscopy, X‐ray Powder Diffraction, Raman Spectroscopy, Scanning Electron Microscopy, and X‐ray Photoelectron Spectroscopy. The synthesized composite was used to remove heavy toxic metal ions (HTMIs) such as uranium (U6+), lead (Pb2+), chromium (Cr6+), and cadmium (Cd2+) ions from aqueous solutions. The HTMIs removal study was carried out to verify the effects of pH, contact time, amount of adsorbent dose, initial concentration, and temperature. The linear and nonlinear Langmuir and Freundlich adsorption isotherms were fitted to the data of removal studies, and it was observed that the linear Langmuir adsorption isotherm (R2 > 0.99) was the best‐fitted model. The maximum adsorption capacities of COOH‐GO‐CMC were found to be 74.62, 416.66, 76.92, and 53.47 mg g−1 for U6+, Pb2+, Cr6+, and Cd2+ ions, respectively. The kinetics studies, including four types of models (linear and nonlinear pseudo‐first‐order, linear and nonlinear pseudo‐second‐order, Intraparticle diffusion, and Elovich kinetic models), were tested, and the results showed that the linear pseudo‐second‐order kinetics model (R2 > 0.99) was the best‐fitted model. The thermodynamic studies reveal that the adsorption of HTMIs is a spontaneous (ΔG < 0) and exothermic (ΔH < 0 and ΔS > 0) process in nature.
Tight globally simple nonzero sum Heffter arrays and biembeddings
Authors: Mella Lorenzo , Pasotti Anita 
Published: November 2022

AbstractSquare relative nonzero sum Heffter arrays, denoted by , have been introduced as a variant of the classical concept of Heffter array. An is an partially filled array with elements in , where , whose rows and whose columns contain filled cells, such that the sum of the elements in every row and column is different from 0 (modulo ) and, for every not belonging to the subgroup of order , either or appears in the array. In this paper we give direct constructions of square nonzero sum Heffter arrays with no empty cells, , for every odd, when is a divisor of and when . The constructed arrays have also the very restrictive property of being “globally simple”; this allows us to get new orthogonal path decompositions and new biembeddings of complete multipartite graphs.
The role of AURKA/miR‐199b‐3p in hepatocellular carcinoma cells
Authors: Li Guogang , Tian Yang , Gao Zhenzhen 
Published: November 2022

AbstractBackgroundPrevious studies proved that AURKA functions as an oncogene in several cancers. This article aimed to probe the miRNA‐induced regulatory mechanism of AURKA in hepatocellular carcinoma (HCC).MethodsDifferentially expressed genes in TCGA‐LIHC dataset were screened by bioinformatics methods. Levels of miR‐199b‐3p and AURKA mRNA were examined by qRT‐PCR. Western blot was utilized to evaluate protein levels of AURKA, p‐AKT, and AKT. Dual‐luciferase assay was introduced to explore their interaction. MTT, colony formation, scratch healing, transwell, and flow cytometry assays were introduced into cell proliferation, migration, invasion, and apoptosis assessment. The impact of miR‐199b‐3p/AURKA axis on HCC tumor growth was determined in a tumor xenograft model.ResultsWe found that AURKA was highly expressed in HCC and was coupled to poor prognosis of HCC. As manifested by cellular assays, compared to the normal cells HL‐7702, AURKA presented notably high expression in HCC cell lines. Overexpressed AURKA evidently impelled the proliferation, colony formation, migration, and invasion of HCC cells while suppressing apoptosis. The regulatory gene upstream of AURKA was predicted to be miR‐199b‐3p by bioinformatics method, and there was a markedly negative correlation between the two. Overexpressed miR‐199b‐3p constrained HCC cell proliferation, migration, and invasion while fostering apoptosis, which could be counteracted by upregulating AURKA. MiR‐199b‐3p repressed the tumor growth in vivo by targeting AURKA and affected PI3K/AKT signaling pathway.ConclusionTo summarize, this study implied the regulatory mechanism of miR‐199b‐3p/AURKA axis in HCC, and supplied optional therapeutic targets for HCC patients.
Double Vizing fans in critical class two graphs
Authors: Cao Yan , Chen Guantao , Qi Xuli 
Published: November 2022

AbstractLet be a simple graph and be the chromatic index of . We call a ‐critical graph if for every edge of , where is maximum degree of . Let be an edge of ‐critical graph and be an (proper) edge ‐coloring of . An e‐fan is a sequence of alternating vertices and distinct edges such that edge is incident with or , is another endvertex of and is missing at a vertex before for each with . In this paper, we prove that if , where and denote the degrees of vertices and , respectively, then colors missing at different vertices of are distinct. Clearly, a Vizing fan is an ‐fan with the restricting that all edges being incident with one fixed endvertex of edge . This result gives a common generalization of several recently developed new results on multifan, double fan, Kierstead path of four vertices, and broom. By treating some colors of edges incident with vertices of low degrees as missing colors, Kostochka and Stiebitz introduced ‐fan. In this paper, we also generalize the ‐fan from centered at one vertex to one edge.
Novel angularly substituted [1,4]thiazino[3,4‐a]isoquinoline carboxylic acids prepared by cyclic imine‐cyclic anhydride reaction
Authors: Pashev Aleksandar , Burdzhiev Nikola , Stanoeva Elena 
Published: November 2022

AbstractThe reaction between 1‐aryl‐3,4‐dihydroisoquinolines and monocyclic anhydrides was studied for the first time. The method is the first one‐step route to previously unknown angularly‐aryl substituted racemic [1,4]thiazino[3,4‐a]isoquinoline derivatives with trans configuration. It was found that electron‐withdrawing substituents in the p‐position of the aryl group in the starting 3,4‐dihydroisoquinoline led to higher yields and shorter reaction times, which is contrary to previous observations for the reactions of homophthalic anhydride and similar acyclic N‐arylmethanimines.
Foreign aid as a catalyst for improving productive capabilities in recipients
Authors: Arpaci‐Ayhan Sevde 
Published: November 2022

AbstractThis article empirically investigates the impact of foreign aid on recipients' productive capabilities. Panel data consists of 86 countries covering the period 2003–2019. The novelty of this study is in linking aid to a new proxy for measuring productive capabilities—the economic complexity index. Because of its ability to predict future growth, economic complexity is valuable in gauging aid effectiveness. The findings show that foreign aid benefits the recipients' economic complexity, although the results are mixed when aid is disaggregated by sector and type at different income levels. Trade openness and foreign direct investment are additional factors affecting economic complexity.