bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobile-Based COVID-19 Vaccination Registration Application Prototype
Authors: Abdillah Leon A. , Kurniasti Azka 
Published: September 2022

Information technology-based applications have entered the era of mobile phones or smartphones such as those using the Android or iOS operating system. Mobile-based application development has become a trend for today's society. Especially during the global COVID-19 pandemic, almost all activities are carried out remotely through mobile-based applications. To prevent the spread of COVID-19, mass vaccines are given to the public. So that the process of administering the vaccine does not cause crowds, it is necessary to create a mobile-based application. So that the application can be further developed properly, it is necessary to make a prototype. The prototype consists of 5 (steps): 1) Quick plan, 2) Modeling Quick Design, 3) Construction of prototype, 4) Deployment Delivery & feedback, and 5) Communication. In this research, the InVision design tool is used which can help design prototypes for both mobile and web versions. InVision has been widely used in making prototypes and is used by many digital companies in the world. The results obtained are in the form of a prototype application for the registration of vaccine participants via mobile phones and also the web. The programmers will easily translate the prototype results into a mobile-based application for the benefit of mobile phone-based online vaccine registration.
O modelo normal não linear
Authors: Fonseca Joeziley Ambrózio da 
Published: September 2022

Quando nos referimos à análise de dados, existe uma gama de modelos que se ajustam aos dados, como modelos de regressão linear e também modelos de regressão não linear. Na estatística a regressão não linear é uma forma da análise de regressão, em que inicialmente uma certa função matemática é ajustada aos dados, é importante ressaltar que esse ajustamento pode ser feito por meio qualitativo usando um diagrama de dispersão. O objetivo principal deste artigo será abordar a técnica de regressão normal não linear, onde será abordado alguns métodos para a estimação dos parâmetros do modelo normal não linear, a precisão dos estimadores, intervalos de confiança, testes de hipóteses, alguns resultados assintóticos e a estimação da variância. Por fim, será analisado um conjunto de dados referente a Coelhos Europeus para demonstrar a aplicabilidade do modelo não linear, em que inicialmente tentamos ajustar o conjunto de dados ao modelo normal linear onde não é obtido êxito no ajustamento e em seguida é considerado o modelo normal não linear, que foi o modelo que melhor se ajustou aos dados.
Complicações cardíacas em pacientes decorrentes da Covid-19
Authors: Bomfim Vitoria Vilas Boas da Silva , Silva Bernardo Coupêe Gonçalves da , Sousa Thalita Bragato , Barbosa Lucas Esteves , Albrecht Hernane Martins , Freitas Lorran Miranda Andrade de , Sales Felipe de Castro Dantas , Milhomem Nayara Lima , Pereira Carlos Eduardo Mantovani , Zanoni Rodrigo Daniel 
Published: September 2022

Introdução: O Coronavírus (CoV) é integrante de um grupo de RNA vírus responsáveis por causarem doenças respiratórias, seja em humanos ou em animais. Essa patologia pode se desenvolver de forma mais leve, moderada ou grave, sendo representada pela Síndrome Respiratória Aguda Grave. Objetivo: Identificar e descrever as complicações decorrentes da COVID-19. Métodos: Trata-se de uma revisão integrativa de literatura realizada na LILACS e MEDLINE, através dos DeCS: Cardiopatias e Coronavírus, disponiveis na integra nos ultiimos três anos, excluidos artigos repetidos nas bases de dados. Resultados: Foram selecionados 7 artigos que retrataram que as principais complicações do coronavírus são cardiacas, o que pode ainda mais piorar o desfecho em cardiopatas e em gestantes. Considerações Finais: Diante do exposto, podemos perceber que as complicações cardiacas eram as mais frequentes e as que tinham um mal preditor no desfecho já que em boa parte dos casos os pacientes evoluiam ao obito pelo combo complicação cardíaca + coronavírus.
Que alimento te conforta?: uma análise retrospectiva sobre mudanças alimentares ocorridas na pandemia
Authors: Maciel Anna Paula Oliveira Alvarez , Rodrigues Airton , Mocellin Michel Carlos , Ayres Ellen Mayra Menezes 
Published: September 2022

A pandemia de COVID-19 fez aumentar o interesse por alimentos de conforto. Diversas pesquisas têm demonstrado mudanças no comportamento e/ou hábitos alimentares da população na busca por uma alimentação “confortável”, ou seja, por alimentos capazes de promover bem-estar e consolo aos indivíduos. Baseando-se no conceito altamente heterogêneo de alimentos confortantes, esta pesquisa teve como objetivo compreender as mudanças alimentares da população e associá-las à procura por alimentos de conforto durante a pandemia de COVID-19. Trata-se de uma revisão narrativa com busca sistematizada por artigos publicados de 11 de março de 2020 a 31 de dezembro de 2021 nas bases de dados da PubMed, Web of Science e Embase, utilizando descritores combinados com auxílio de operadores booleanos: (COVID-19 OR Sars-CoV-2) AND (feeding behavior OR food habit* OR comfort food OR eating emotional). Foram incluídos 23 artigos originais, totalizando 120.569 pessoas avaliadas, com predomínio de estudos transversais e população adulta. Foram observadas tanto mudanças alimentares positivas, tais como: aumento no consumo de frutas, verduras e legumes, maior adesão à dieta do mediterrâneo e aumento de consumo de preparações caseiras, assim como as negativas: aumento no consumo de alimentos ricos em açúcares e/ou gorduras, maior consumo de alimentos ultraprocessados, lanches rápidos, salgadinhos e comida industrializada. Conforme a taxonomia situacional de alimentos confortantes, descrita por Julie Locher (comidas nostálgicas, comidas de indulgência, comidas de conveniência e comidas de conforto físico), e as características altamente idiossincráticas desta categoria de alimentos, esta revisão sugere que possa existir uma relação positiva entre as mudanças alimentares decorrentes da pandemia de COVID-19 e a busca por alimentos capazes de promover bem-estares físico e/ou emocional ao indivíduo.
Perfil funcional do paciente pós alta da Unidade de Terapia Intensiva
Authors: Carvalho Lêda Leonôr Mendonça , Santos Ingrid Mendes , Alves Maria Emília Dantas , Silva Anne Aurielly de Almeida , Cruz Johnatan Weslley Araujo , Almeida Lucas Aragão da Hora , Cerqueira Telma Cristina Fontes 
Published: September 2022

Introdução: Mesmo frente ao grande número de pacientes que tem uma sobrevida pós alta da Unidade de Terapia Intensiva (UTI), a maioria sobre complicações que afetam sua funcionalidade. Objetivo: Avaliar o perfil funcional do paciente pós alta da unidade de terapia intensiva e identificar os fatores determinantes que influenciam na funcionalidade. Metodologia: Estudo longitudinal, observacional e descritivo, tendo uma abordagem quantitativa incluindo pacientes admitidos na UTI de um Hospital Universitário no Estado de Sergipe, no período de agosto de 2018 a março de 2020. Como instrumento de pesquisa, foi usada a Medida de Independência Funcional (MIF) em três momentos: na admissão hospitalar, para mensuração da independência funcional prévia à internação hospitalar, na admissão na UTI, para mensuração da funcionalidade prévia à internação na UTI; e na alta imediata . Resultados: A amostra foi composta por 206 pacientes, sendo incluídos 91 participantes. Observou-se uma redução da MIF na admissão na UTI comparada à MIF prévia hospitalar e uma tendência à elevação na alta, porém os valores não retornam ao que foi observado antes da internação hospitalar. Além disso, aqueles pacientes com idade mais avançada e que utilizaram ventilação mecânica por um maior período e com um maior tempo de internação, foram determinantes para a MIF após a alta da UTI. Conclusão: Conclui-se que o processo de hospitalização, especialmente na UTI, de pacientes de idade mais avançada, em uso ventilação mecânica e com um maior tempo de internação, provoca uma redução significativa na funcionalidade.
Compartilhando saberes, sabores e saúde através de ensaio gastronômico sustentável
Authors: Nascimento Maria do Carmo Freitas , Viçosi Paulo Willian Brunelli , Barbieri Bruno Kapitsyki , Nascimento Maria Veronica Freitas , Breier Tiago Böer , Oliveira Valéria Rodrigues de 
Published: September 2022

Relato de experiência gastronômica realizada com Grupo de Mulheres da Comunidade de São Pedro Frio, zona rural do município de Colatina, estado do Espírito Santo, Brasil, durante o Encontro “Sabor e Prosa”. Este encontro descendeu de um projeto que teve como objetivo o estudo do potencial ecoturístico de São Pedro Frio através do método de construção de cartografias socioambientais, como proposta de pesquisa participativa. A alimentação tem papel fundamental na vida humana e o incentivo a oferta de alimentos saudáveis têm ampliado entre os diferentes setores. Atualmente, a gastronomia assumi outras proporções, incluindo o lúdico, artístico e de saúde. A experiência foi realizada em duas etapas presenciais e por meio de contatos telefônicos. O ensaio foi planejado com vista na utilização de recursos naturais atrelados aos conceitos de sustentabilidade e alimentação saudável. Foi observado integração entre o grupo e discussões sobre a utilização de ingredientes como espécies de plantas alimentícias não convencionais. O cardápio apresentado, a saber: canapé de tapioca com geleia de manga, folha de ora-pro-nóbis e flor de jambo, peixe à prosa (filé de tilápia empanado e descansado em cheio verde), arroz com manjericão e castanha de caju, vinho tinto e suco natural de uva. Práticas gastronômicas em comunidades rurais que estimulem o potencial gastronômico podem servir como instrumento para o fortalecimento de uma gastronomia turística sustentável e saudável.
Harnessing hyaluronic acid for the treatment of osteoarthritis: A bibliometric analysis
Authors: Zhang Jun , Lin Miaoyuan , Huang Yanran , Wang Yuping , Huang Tianji , Wu Zhillin , Li Zefang , Xu Jingtao , Zhao Runhan , Luo Xiaoji 
Published: September 2022

Background: Osteoarthritis (OA) is a common disease which usually occurs in middle-aged and elderly people. Hyaluronic acid (HA) has been widely used to treat OA and related researches on the efficacy and safety of HA in the treatment of OA have been published. Therefore, the purpose of this research was to investigate the subject characteristics of harnessing HA for the treatment of OA and to analyse the relevant trends and hotspots by using a bibliometric approach.Methods: The articles published from 1 January 2002 to 31 December 2021 were searched in the Web of Science Core Collection (WoSCC) and the relevant information of HA for the treatment of OA was extracted after screening. Then, a total of 2438 publications were analysed by using Microsoft Excel, CiteSpace 5.8.R3, VOSviewer 1.6.18 and the Online Analysis Platform of Literature Metrology (http://bibliometric.com/).Results: A total of 2438 articles were finally included for analysis. The number of publications increased year by year. A total of 83 coutries and 3319 institutions published 2438 manuscripts in the field of use HA for the treatment of OA. The most productive country was United States with total 689 publications and League of European Research Universities Leru (Belgium) was the leading institution with total 126 publicatios. In terms of authors, the most prominent author was KrausVB, who published 28 papers with the highest H-index (19). In addition, Osteoarthritis and Cartilage had the highest number of publications (152 articles) and the highest number of citations (6450 citations). The co-cited references analysis indicated that the article published by McAlindon in 2014 had the most highest number of citations (91co-citations). What’s more, most research hotspots focused on the efficacy and safety of HA, and regenerative medicine researches such as platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) have attracted more and more attentions of researchers.Conclusion: This study visually analyzed the historical evolution and future trends of HA for the treatment of OA, and discussed the research priorities. At present, there are still different views on the efficacy of HA for the treatment of OA. Gradually, research hotspots of this field have focused on the regenerative medicine.
Physically stimulus-responsive nanoparticles for therapy and diagnosis
Authors: Farjadian Fatemeh , Ghasemi Soheila , Akbarian Mohsen , Hoseini-Ghahfarokhi Mojtaba , Moghoofei Mohsen , Doroudian Mohammad 
Published: September 2022

Nanoparticles offer numerous advantages in various fields of science, particularly in medicine. Over recent years, the use of nanoparticles in disease diagnosis and treatments has increased dramatically by the development of stimuli-responsive nano-systems, which can respond to internal or external stimuli. In the last 10 years, many preclinical studies were performed on physically triggered nano-systems to develop and optimize stable, precise, and selective therapeutic or diagnostic agents. In this regard, the systems must meet the requirements of efficacy, toxicity, pharmacokinetics, and safety before clinical investigation. Several undesired aspects need to be addressed to successfully translate these physical stimuli-responsive nano-systems, as biomaterials, into clinical practice. These have to be commonly taken into account when developing physically triggered systems; thus, also applicable for nano-systems based on nanomaterials. This review focuses on physically triggered nano-systems (PTNSs), with diagnostic or therapeutic and theranostic applications. Several types of physically triggered nano-systems based on polymeric micelles and hydrogels, mesoporous silica, and magnets are reviewed and discussed in various aspects.
Baroreflex sensitivity predicts therapeutic effects of metoprolol on pediatric postural orthostatic tachycardia syndrome
Authors: Cui Yaxi , Wang Yuanyuan , Liu Ping , Wang Yuli , Du Junbao , Jin Hongfang 
Published: September 2022

ObjectiveTo determine if the baseline baroreflex sensitivity (BRS) could be a useful predictor for the metoprolol therapeutic efficacy on postural orthostatic tachycardia syndrome (POTS) in children.MethodsIn this retrospective case-control study, 54 children suffering from POTS treated with metoprolol were recruited from the pediatric department of Peking University First Hospital. After 2–3 months of metoprolol treatment, all subjects were divided into responders and non-responders based on whether the symptom score (SS) was decreased by over 50% after metoprolol treatment at the follow-up. The baseline demographic parameters and the supine BRS during the head-up tilt test (HUTT) obtained by Finapres Medical System (FMS) were compared between the two groups. The value of BRS to predict the effectiveness of POTS was analyzed by a receiver-operating characteristic (ROC) curve.ResultsThe age, sex, height, weight, body mass index (BMI), course of the disease, baseline SS, medication time, metoprolol dose, and follow-up time of the subjects were not statistically different between the responders and non-responders (P &gt; 0.05). The decline in symptom scores (ΔSS) of the responders was more obvious than that of the non-responders (P &lt; 0.01). The supine BRS, BRS at maximum HR, supine heart rate (HR), and maximum HR were different between responders and non-responders (P &lt; 0.01, P = 0.022, P &lt; 0.01, P = 0.047). The binary multivariable analysis showed that baseline supine BRS was significantly associated with the response to metoprolol therapy [OR: 2.079, 95% CI: (1.077, 4.015), P = 0.029]. According to the ROC curve, the area under the curve (AUC) of baseline BRS was 0.912 (95% CI, 0.840–0.984), with a cut-off value of 8.045 ms/mmHg, yielding a sensitivity and specificity of 75.8% and 95.2%, respectively, in predicting the effectiveness of POTS.ConclusionThe baseline supine BRS level &gt; 8.045 ms/mmHg can predict a good therapeutic response to metoprolol and the results would assist in guiding the individualized β-adrenoceptor blocker use in pediatric patients suffering from POTS.
The effects of season (spring versus autumn) on diagnosis of normocalcemic primary hyperparathyroidism
Authors: Basińska-Lewandowska Magdalena , Lewiński Andrzej , Lewandowski Krzysztof C. , Skowrońska-Jóźwiak Elżbieta 
Published: September 2022

BackgroundRaised parathormone (PTH) and normal calcium concentrations can be observed both in normocalcemic primary hyperparathyroidism (nPHPT) and in secondary hyperparathyroidism, e.g. due to vitamin D deficiency. We assessed the impact of season on the validity of diagnosis of nPHPT in terms of screening investigations to be performed in the primary care settings.Material and methodsOn two occasions (March/April &amp; September/October) we measured vitamin D (25OHD), PTH and total calcium in 125 healthy subjects, age range 6-50, not taking any vitamin D supplements.ResultsIn autumn there was an increase in 25OHD concentrations (from 18.1 ± 7.37ng/ml to 24.58 ± 7.72ng/ml, p&lt;0.0001), a decline in PTH from 44.40 ± 17.76pg/ml to 36.63 ± 14.84pg/ml, p&lt;0.001), without change in calcium levels. Only 45 subjects (36%) were vitamin D sufficient (25OHD&gt;20/ml) in spring versus 83 (66.4%) in autumn, p&lt;0.001. Elevated PTH concentrations were noted in 10 subjects in spring (8%) and in six subjects (4.8%) (p&lt;0.05) in autumn. In spring, however, eight out of ten of these subjects (80%) had 25OHD&lt;20 ng/ml, versus one in six (16.7%) in autumn (p&lt;0.01). Normalization of PTH was observed in seven out ten subjects (70%), and all of them had 25-OHD&lt;20 ng/ml in spring.ConclusionsIn spring elevated PTH concentrations in the setting of normocalcemia are more likely to be caused by 25OHD deficiency rather by nPHPT. In contrast, in autumn, increased PTH concentrations are more likely to reflect nPHPT. We postulate that screening for nPHPT should be done in 25OHD replete subjects, i.e. in autumn rather than in spring.
Expression profiling suggests the involvement of hormone-related, metabolic, and Wnt signaling pathways in pterygium progression
Authors: Li Jiarui , Tao Tianchang , Yu Yingying , Xu Ningda , Du Wei , Zhao Mingwei , Jiang Zhengxuan , Huang Lvzhen 
Published: September 2022

BackgroundPterygium is an ocular surface disease that can cause visual impairment if it progressively invades the cornea. Although many pieces of research showed ultraviolet radiation is a trigger of pterygium pathological progress, the underlying mechanism in pterygium remains indistinct.MethodsIn this study, we used microarray to evaluate the changes of transcripts between primary pterygium and adjacent normal conjunctiva samples in China. Then, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses. Moreover, we constructed protein-protein interaction (PPI) and miRNA-mRNA regulatory networks to predict possible regulatory relationships. We next performed gene set enrichment analysis (GSEA) to explore the similarities and differences of transcripts between Asian studies from the Gene Expression Omnibus database. Furthermore, we took the intersection of differentially expressed genes (DEGs) with other data and identified hub genes of the development of pterygium. Finally, we utilized real-time quantitative PCR to verify the expression levels of candidate genes.ResultsA total of 49 DEGs were identified. The enrichment analyses of DEGs showed that pathways such as the Wnt-signaling pathway and metabolism-related pathways were upregulated, while pathways such as hormone-related and transcription factor-associated pathways were downregulated. The PPI and miRNA-mRNA regulatory networks provide ideas for future research directions. The GSEA of selecting Asian data revealed that epithelial-mesenchymal transition and myogenesis existed in the pathology of pterygium in the Asian group. Furthermore, five gene sets (interferon-gamma response, Wnt beta-catenin signaling, oxidative phosphorylation, DNA repair, and MYC targets v2) were found only in our Chinese datasets. After taking an intersection between selecting datasets, we identified two upregulated (SPP1 and MYH11) and five downregulated (ATF3, FOS, EGR1, FOSB, and NR4A2) hub genes. We finally chose night genes to verify their expression levels, including the other two genes (SFRP2 and SFRP4) involved in Wnt signaling; Their expression levels were significantly different between pterygium and conjunctiva.ConclusionsWe consider hormone-related, metabolic, and Wnt signaling pathways may be important in the pathology of pterygium development. Nine candidate genes we identified deserve further study and can be potential therapeutic targets.
Osteoporosis and sarcopenia-related traits: A bi-directional Mendelian randomization study
Authors: Liu Chao , Liu Ningyuan , Xia Yu , Zhao Ziyue , Xiao Tao , Li Hui 
Published: September 2022

BackgroundWith the advancement of world population aging, age-related osteoporosis (OP) and sarcopenia (SP) impose enormous clinical and economic burden on society. Evidence from accumulating studies indicates that they mutually influence one another. However, an observational study may be affected by potential confounders. Meanwhile, a Mendelian randomization (MR) study can overcome these confounders to assess causality.ObjectivesThe aim of this study was to evaluate the causality between OP and SP, informing new strategies for prevention, diagnosis, and treatment of osteosarcopenia.MethodsInstrumental variables (IVs) at the genome‐wide significance level were obtained from published summary statistics, and the inverse variance weighted method and several other MR methods were conducted to evaluate the bi-directional causality between SP and OP. Myopia was analyzed as a negative control outcome to test the validity of IVs.ResultsFemoral neck bone mineral density (FN BMD), lumbar spine BMD (LS BMD), and forearm BMD (FA BMD) had a direct causal effect on appendicular lean mass (ALM) [FA BMD-related analysis: odds ratio (OR) = 1.028, 95% confidence interval (CI) = (1.008,1.049), p = 0.006; FN BMD-related analysis: OR (95% CI) = 1.131 (1.092,1.170), p = 3.18E-12; LS BMD-related analysis: OR (95% CI) = 1.080 (1.062,1.098), p = 2.86E-19]. ALM had a significant causal effect on LS BMD [OR (95% CI) = (1.033,1.147), p = 0.001]. There was no evidence for causal association between BMD and low grip strength.ConclusionsOP and SP might mutually have a significant causal effect on each other. Our results supported the idea that the patient with severe OP was more susceptible to lose ALM and severe ALM loss might reduce LS BMD.