bluuebunny/crossref_metadata_2025_split huggingface dataset:
If I’m not Streaming, I’m not Earning: Audience Relations and Platform Time on Douyin
Authors: Fung Anthony , Ismangil Milan , He Wei , Cao Shule 
Published: June 2022

Abstract

Purpose
This article explores how platforms reorganize our sense of everyday life. The platformization of everyday life means a changing relation to what we do in our daily lives, not only in China, but in every country in which digital platforms are becoming more relevant by the day. Using TikTok in China as our point of departure, we discuss the role of platform time and the abstracted audience.

Design/methodology/approach
This study is a collaboration between Douyin of ByteDance, whose headquarters are in Beijing, and a team of researchers. Users with more than 10,000 followers were identified so as to select users who had sufficient activities and strong motivation to operate their short video channel. A survey questionnaire was sent to these users during one week in July 2019, and 2375 users responded to the survey. For this paper, after briefly reading the survey results, we selected 50 users for in-depth interviews. The users gave their consent to disclose their identity. In the process, ByteDance helped contact these users.

Findings
Based on the data, we discuss two concepts, abstract audiences and platform time, which helped us to understand platform–labor relations. We argue that while there is the illusion that audiences are closer than ever to the content creator in terms of engagement, at the same time, they are abstracted through platform analytics, meaning that they are reduced to statistics provided to content creators.

Originality/value
Rather than being liberated, creators are restricted by a new form of time that offers the possibilities of freedom within the confines of the platform. Rather than having fixed working hours, creators are self-regulating as streaming hours and upload times demand certain patterns to increase one’s following and make a living, while as creators, they must also try to understand their audience and the platform algorithm.
Sublethal effects of acrylamide on thyroid hormones, complete blood count and micronucleus frequency of vertebrate model organism (Cyprinus carpio)
Authors: Erkmen Belda , Günal Aysel Caglan , Polat Hüseyin , Erdoğan Kenan , Civelek Hilal , Erkoç Figen 
Published: June 2022

Abstract

Objectives
Acrylamide, a widely used chemical in industry, clinical laboratory and waste treatment plants, is considered a carcinogen in humans. The present study examined the hormonal, hematologic, and genotoxic responses in the invertebrate model common carp Cyprinus carpio after exposure to sublethal acrylamide.

Methods
Fish were exposed to acrylamide at 10 and 50 mg/L for 96 h, along with the respective control group. Serum levels of cortisol and thyroid hormones were measured using diagnostic ELISA direct immunoenzymatic kits. For micronucleus (MN) frequency assay, thin smears of the peripheral blood of fish were prepared.

Results
Serum levels of cortisol in both treatment groups considerably increased, which proposed that acrylamide caused a stress reaction of acrylamide exposed fish (p<0.05). Fish demonstrated significant decreases in triiodothyronine (T3), free thyroxine (FT4), and free triiodothyronine (FT3) concentrations in a dose-dependent manner after acrylamide exposure (p<0.05). However, serum thyroxine (T4) concentrations did not alter significantly in the treatment groups. Mean MN frequencies of fish erythrocytes increased significantly in acrylamide exposed groups suggesting that acrylamide is genotoxic in common carp (p<0.05). The hematocrit, hemoglobin, and erythrocyte numbers of carp increased significantly in exposure groups (p<0.05).

Conclusions
These results suggested that acrylamide can significantly affect the hemopoietic system. Furthermore, this study confirmed that the widespread use of acrylamide, even in sublethal concentrations, could affect the survival of non-target organisms, especially fish, in aquatic environments.
Visual System Hyperexcitability and Compromised V1 Receptive Field Properties in Early-Stage Retinitis Pigmentosa in Mice
Authors: Leinonen Henri , Lyon David C. , Palczewski Krzysztof , Foik Andrzej T. 
Published: June 2022

AbstractInherited retinal degenerative diseases are a prominent cause of blindness. Although mutations causing death of photoreceptors are mostly known, the pathophysiology downstream in the inner retina and along the visual pathway is incompletely characterized in the earliest disease stages. Here, we investigated retinal, midbrain and cortical visual function using electroretinography (ERG), the optomotor response (OMR), visual evoked potentials (VEPs), respectively, and single unit electrophysiology at the primary visual cortex (V1) in light-adapted juvenile (approximately one-month-old) and young adult (three-month-old)RhoP23H/WTmice, representative of early-stage retinitis pigmentosa (RP). Photopic ERG revealed up to ∼30% hypersensitivity to light inRhoP23H/WTmice, as measured by the light intensity required to generate half-maximal b-wave (I50parameter).RhoP23H/WTmice also showed increased OMRs toward low spatial frequency (SF) drifting gratings, indicative of visual overexcitation at the midbrain level. At the V1 level, VEPs and single-cell recordings revealed prominent hyperexcitability in the juvenileRhoP23H/WTmice. Mean VEP amplitudes for light ON stimuli were nearly doubled in one-month-oldRhoP23H/WTmice compared with controls, and more than doubled for light OFF. Single-cell recordings showed a significantly increased spontaneous V1 neuron firing in theRhoP23H/WTmice, and persistent contrast and temporal sensitivities. In contrast, direction selectivity was severely compromised. Our data suggest that during early RP, the visual pathway becomes hyperexcited. This could have both compensatory and deleterious consequences for visual behavior. Further studies on the mechanisms of hyperexcitability are warranted as this could lead to therapeutic interventions for RP.
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs
Authors: Carvelli Andrea , Setti Adriano , Desideri Fabio , Galfrè Silvia Giulia , Biscarini Silvia , Santini Tiziana , Colantoni Alessio , Peruzzi Giovanna , Marzi Matteo Jacopo , Capauto Davide , Di Angelantonio Silvia , Ballarino Monica , Nicassio Francesco , Laneve Pietro , Bozzoni Irene 
Published: June 2022

AbstractThe transition from dividing progenitors to postmitotic motor neurons (MNs) is orchestrated by a series of events, which are mainly studied at the transcriptional level by analyzing the activity of specific programming transcription factors. Here, we identify a post‐transcriptional role of a MN‐specific transcriptional unit (MN2) harboring a lncRNA (lncMN2‐203) and two miRNAs (miR‐325‐3p and miR‐384‐5p) in this transition. Through the use of in vitro mESC differentiation and single‐cell sequencing of CRISPR/Cas9 mutants, we demonstrate that lncMN2‐203 affects MN differentiation by sponging miR‐466i‐5p and upregulating its targets, including several factors involved in neuronal differentiation and function. In parallel, miR‐325‐3p and miR‐384‐5p, co‐transcribed with lncMN2‐203, act by repressing proliferation‐related factors. These findings indicate the functional relevance of the MN2 locus and exemplify additional layers of specificity regulation in MN differentiation.
Cooperative amyloid fibre binding and disassembly by the Hsp70 disaggregase
Authors: Beton Joseph George , Monistrol Jim , Wentink Anne , Johnston Erin C , Roberts Anthony John , Bukau Bernd Gerhard , Hoogenboom Bart W , Saibil Helen R 
Published: June 2022

AbstractAlthough amyloid fibres are highly stable protein aggregates, a specific combination of human Hsp70 system chaperones can disassemble them, including fibres formed of α‐synuclein, huntingtin, or Tau. Disaggregation requires the ATPase activity of the constitutively expressed Hsp70 family member, Hsc70, together with the J domain protein DNAJB1 and the nucleotide exchange factor Apg2. Clustering of Hsc70 on the fibrils appears to be necessary for disassembly. Here we use atomic force microscopy to show that segments of in vitro assembled α‐synuclein fibrils are first coated with chaperones and then undergo bursts of rapid, unidirectional disassembly. Cryo‐electron tomography and total internal reflection fluorescence microscopy reveal fibrils with regions of densely bound chaperones, preferentially at one end of the fibre. Sub‐stoichiometric amounts of Apg2 relative to Hsc70 dramatically increase recruitment of Hsc70 to the fibres, creating localised active zones that then undergo rapid disassembly at a rate of ~ 4 subunits per second. The observed unidirectional bursts of Hsc70 loading and unravelling may be explained by differences between the two ends of the polar fibre structure.
Role of glucocorticoid metabolism in childhood obesity-associated hypertension
Authors: Finken Martijn J J , Wirix Aleid J G , von Rosenstiel-Jadoul Ines A , van der Voorn Bibian , Chinapaw Mai J M , Hartmann Michaela F , Kist-van Holthe Joana E , Wudy Stefan A , Rotteveel Joost 
Published: June 2022

Objective
Childhood obesity is associated with alterations in hypothalamus–pituitary–adrenal axis activity. We tested the hypothesis that multiple alterations in the metabolism of glucocorticoids are required for the development of hypertension in children who become overweight.

Methods
Spot urine for targeted gas chromatography-mass spectrometry steroid metabolome analysis was collected from (1) overweight/hypertensive children (n  = 38), (2) overweight/non-hypertensive children (n  = 83), and (3) non-overweight/non-hypertensive children (n  = 56).

Results
The mean (± s.d.) age of participants was 10.4 ± 3.4 years, and 53% of them were male. Group 1 and group 2 had higher excretion rates of cortisol and corticosterone metabolites than group 3 (869 (interquartile range: 631–1352) vs 839 (609–1123) vs 608 (439–834) μg/mmol creatinine × m2 body surface area, P < 0.01, for the sum of cortisol metabolites), and group 1 had a higher excretion rate of naive cortisol than group 3. Furthermore, groups differed in cortisol metabolism, in particular in the activities of 11β-hydroxysteroid dehydrogenases, as assessed from the ratio of cortisol:cortisone metabolites (group 2 < group 3), 5α-reductase (group 1 > group 2 or 3), and CYP3A4 activity (group 1 < group 2 or 3).

Discussion
The sequence of events leading to obesity-associated hypertension in children may involve an increase in the production of glucocorticoids, downregulation of 11β-hydroxysteroid dehydrogenase type 1 activity, and upregulation of 5α-reductase activity, along with a decrease in CYP3A4 activity and an increase in bioavailable cortisol.
Predictors of young adults’ movement capability in physical activity
Authors: Garcia Marino A. 
Published: June 2022

Background And Study Aim. The purpose of the study is to identify the predictors of the movement capability of the individuals in physical activity.
Materials and Methods. Quantitative descriptive predictive method was employed in identifying the significant relationship of the identified factors that can predict movement capability in physical activity. There were 263 participants in the study from one of the Higher Educational Institutions in Cebu City, Philippines which were randomly sampled using Raosoft Sample Size Calculator. Experts validated research instruments were used and data gathered were analyzed using descriptive (percentile, mean, standard deviation) and inferential statistics (multiple regression).
Results. Findings revealed that only three factors: blood type, attitude towards physical activity, and perceived action – scaled affordance were predictors of movement capability and five movement dimensions were influenced by blood type, attitude towards physical activity, and perceived action – scaled affordance. Thus, blood type is predictor to flexibility, accuracy, speed and endurance. On the other hand, attitude towards physical activity is predictor of endurance. While, perceived action – scaled affordance is predictor of strength, accuracy and endurance.
Conclusions. It was concluded that a person’s capability to engage in physical activity is contributed by biological factors (blood type) and psychological factors (attitude and perceived action-scaled affordance). It is recommended that validation study be conducted to strengthen the claims of the identified factors to movement capability of an individual.
Development of balance training program to improve balance control among Malaysian sports schools athletes
Authors: Lee Ai Choo , Sankaravel Mohansundar , Hossein Abadi Fariba , Zainudin Fairus Fariza 
Published: June 2022

Background and Study Aim. Complex sports specific movements often require balance ability. This is accountable for injury prevention as well. Balance control is vital to athletes for all sports activities. It is the objective of the current study to develop and identify balance training program effectiveness in improving dynamic balance among athletes in Malaysian National Sport Schools.
Material and Methods. This study used a true experimental with control group design, involved dynamic balance control measures before and after intervention. A total of 72 male and female athletes were randomly assigned into experimental group or control group after screening process for eligibility. The experimental group underwent 12 sessions of balance training program and the control group continued their usual training routine. The Y-Balance Test was utilized to quantify dynamic balance for both groups. Data was analyzed using independent and paired sample t-test.
Results. The study finding indicated that the experimental group demonstrated significant improvement in the post-test compared to pre-test (p = 0.000, p < 0.001) but no significant changes happened to control group (p = 0.353, p > 0.05). Independent t-test showed during post-test, the experimental group attained better score compared to the control group (p = 0.000, p < 0.001).
Conclusions. It is suggested that coaches and athletes may include this balance training program in their training regimen, hoping to help in improving dynamic balance, thus, to reduce risk of lower extremity injuries. Future studies are suggested to increase more variances of balance training and make comparison on their effectiveness as a way to obtain a more effective training program.
Discrimination of South American grains based on fatty acid
Authors: Ferreira Daniela Souza , Barbosa Rocha Júlio Cesar , Arellano Daniel Barrera , Lima Pallone Juliana Azevedo 
Published: June 2022

This study developed a method for discriminating between Andean indigenous crops and hybrid crops, using total lipid composition, fatty acid profiles, and statistical comparison. Cluster analysis and Principal Component Analysis (PCA) revealed the standard fingerprints of the gas chromatography-FID and the primary fatty acids related to loadings, which shows the explained variance (91.4–99.5%) of the total 32 cultivars, including quinoa (Chenopodium quinoa), amaranth (Amaranthus), and triticale (X Triticosecale), collected from Brazil, Bolivia, Peru, and Argentina. The primary fatty acids found in quinoa, amaranth, and triticale were linoleic (essential PUFA) (36.59–63.04 g 100 g−1), oleic (11.95–36.95 g 100 g−1), and palmitic (essential MUFA) (9.40–20.20 g 100 g−1). All grains presented four groups with the PCA method, with the exception of amaranth, with three groups. Analysed separately, linoleic and eicosenoic acids are related to quinoa; stearic and palmitic acids to amaranth; and linolenic and oleic acids to triticale.
Acts of Planning in Administration: Towards Support for the Development of the Social Economy
Authors: Szmigiero Maciej 
Published: June 2022

Background: Public planning plays an increasingly important role as planning acts issued by the administration form the basis for the actions of public authorities, including determining the directions of legislative activity. Therefore, they are the subject of interest in the doctrine of public law.
Research objectives: The aim of this paper is to explore selected governmental development policy documents assessed from the point of view of social economy development in order to show both their complexity and the range of their subject matter. The issue of theoretical foundations of planning in administration and their scope was also taken into account..
Research design and methods: The research method used in the study is the legal-dogmatic method and the theoretical-legal method.
Results: Findings of the study expose that although in selected government strategic documents reference is made to social economy issues, due to the exclusively internal nature of planning acts and the overly general provisions of the analysed strategies, they can hardly provide a basis for coordinated action.
Conclusions: The study identifies a need for greater precision in the provisions so that they can become a basis for specific actions by the administration, including drafting of legislation.
Prevalencia de reacciones adversas transfusionales y su asociación con características clínicas en un banco de sangre en Medellín
Authors: Higuita Gutiérrez Luis Felipe , Zuluaga Gómez Lucas , Tapie Piarpuezan Elizabeth , Flórez Duque Jenniffer 
Published: June 2022

Introducción: La transfusión sanguínea es un procedimiento terapéutico en el que se administra un componente sanguíneo de un individuo a otro, el procedimiento no está exento de generar reacciones adversas transfusionales (RAT) que son respuestas indeseadas e imprevistas que se presentan durante o después de la transfusión. Objetivo: estimar la prevalencia de RAT y su asociación con características clínicas en un banco de sangre de Medellín-Colombia. Métodos: estudio descriptivo en 9576 pacientes que requirieron transfusión sanguínea entre los años 2014 y 2018. Se utilizó una fuente de información secundaria de la cual se tomaron las variables demográficas, clínicas, los resultados de las pruebas pre-transfusionales y de las reacciones transfusionales. La información se analizó con frecuencias absolutas, relativas y su intervalo de confianza del 95%, el análisis bivariado se hizo con el estadístico Chi-cuadrado de Pearson. Resultados: el 1,1% (IC 95% 0,88-1,31) de los pacientes presentaron RAT, predominaron las reacciones alérgicas, sobrecarga circulatoria y reacción febril no hemolítica. La prevalencia de RAT fue mayor entre quienes tenían 19 a 26 años [2,4% (IC 95% 1,1-4,6)], y en pacientes con enfermedades del sistema genitourinario [1,6% (IC 95% 0,7-3,2)] y atendidos por medicina interna [1,7% (IC 95%1,3-2,3)]. Conclusión: La prevalencia de RAT encontrada en este estudio muestra discrepancias con lo descrito en otros países y, pone de manifiesto la necesidad de fortalecer los sistemas de hemovigilancia en cada contexto. Además, refleja la importancia de monitorear los procesos de seguridad del paciente en el nivel de la calidad de los componentes sanguíneos a transfundir, el estudio de los factores de riesgo en el receptor y los errores técnicos que pueden presentarse durante el procedimiento.
Association between screen time exposure, anxiety, and sleep quality in adolescents
Authors: Santiago Fátima Larissa , Oliveira da Silva Alison , Souza Silva Raflésio Ivanildo de , Castro Melo Wilson Viana de , Rodrigues Filho Edil de Albuquerque , Torres Pirauá André Luiz , Farah Breno Quintella , Machado-Oliveira Luciano 
Published: June 2022

Introduction. The increase in sedentary screen time can negatively affect the quality of sleep, impacting the performance of daily activities. Objective. To analyze the association between sedentary screen time and sleep quality, regardless of the symptoms of anxiety in adolescents of both genders. Method. Cross-sectional study integrating school-based epidemiological research with a representative sample (n = 666) of high school students (14 to 19 years old) in public schools in the municipality of Caruaru-PE. The translated versions into Portuguese of the Pittsburgh Sleep Quality Index (PSQI) and the Hospital Anxiety and Depression Scale (HAD) were applied to analyze sleep quality and anxiety, respectively. Binary logistic regression was used to analyze the association, considering sleep quality as an outcome. Results. There was a positive, statistically significant (p #abr# .001) correlation between sleep quality and symptoms of anxiety (r = .393). A significant association regarding the association between screen time and sleep quality was noted only in those adolescents classified as being possible or probable anxiety cases and only in exposure to the computer (OR = 2.337; 95% CI [1.01, 5.43]) and video games (OR = 8.083; 95% CI [2.0, 32.8]) after adjusting for gender, age, and school shift. Discussion and conclusion. Increased interaction with the screen and higher levels of anxiety can be more harmful to sleep in adolescents. Exposure to screen time, specifically those which have a greater interaction such as video games and computers, can have a negative impact on sleep quality, but only in adolescents with a higher risk of anxiety.
Excavating CBC’s Docudrama The Tar Sands
Authors: McCurdy Patrick 
Published: June 2022

This article examines the political controversy around the banned 1977 CBC docudrama _The Tar Sands_, which portrays the personal and political struggle of Alberta Premier Peter Lougheed to secure the Syncrude agreement to develop Alberta’s bitumen sands. Immediately following the docudrama’s broadcast, Lougheed launched a lawsuit which ultimately resulted in the show’s expulsion from CBC archives. While the CBC docudrama sought to dramatize and elevate political critiques of the tar sands, Lougheed’s litigious reaction quickly buried them, obfuscating the real possibility that The Tar Sands—while a work of fiction—portrays the genesis of Alberta’s corporate capture by foreign oil.
The Association of Sociodemographic and Clinicopathological with Survival of Breast Cancer Patients
Authors: Tejo Jayadi 
Published: June 2022

Background: The research of breast cancer prognostic factors has been conducting for a long time, but the results still controversial. The research on demography and clinicopathology factors that determine the survival of breast cancer (BC) patients, remains to be done.
Methods: The observational analytic with cross-sectional design would be conduct to describe the demographic, clinicopathology, therapy and two years survival of breast cancer patients. The independent variables were age, stage of disease, and molecular subtype. The dependent variable was two years survival. The association between those variables analyzed by bivariate statistic and the significant variables would be analyzed by regression logistic.
Results: Most age of breast cancer patients at diagnosis were ≥ 50 years (74.5%). The majority of sociodemographic profiles of BC patients were undergraduate education, private job and married. The main histological type was the invasive ductal carcinoma. More than 50% of the patients were high stage (60.8%) and hormonal receptors molecular subtype (60.7%). Neoadjuvant chemotherapy was given to 40 patients (78.5%), only 9 patients (17.7%) eligible for anti HER-2/neu therapy. There were 42 of patients (82.4%) have two years survival. There weren’t association between age (p=0.586), stage of disease (p=0.223), molecular subtype (p=0.223) with two years survival of breast cancer patients.
Conclusions: The common risk factors of breast cancer is increasing age. Most of breast cancer patients presenting high stage and hormone receptors positive of BC. Although there weren’t significance association, the prevalence low stage BC patients had higher two years survival.