bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relação entre condições socioeconômicas e o perfil do autocuidado dos idosos Universidade da Maturidade da Universidade Federal do Tocantins
Authors: Silva Elzivania de Carvalho , Ribeiro Emerson Moura , Figueiredo Andrea Furtado Bruno , Neila Barbosa Osório Neila Barbosa , Silva Neto Luiz Sinésio 
Published: July 2022

Este trabalho tem como objetivo verificar a relação entre autocuidado e condições socioeconômicas dos idosos de um programa de Aprendizagem ao longo da vida da Universidade Federal do Tocantins, demonstrar os resultados das intervenções de educação em saúde com a utilização de pré e pós-teste com a aplicação do questionário ASA-A. Trata-se de um estudo transversal, descritivo de enfoque quantitativo realizado com 38 idosos entre 60 e 75 anos do programa localizado na cidade de Palmas-TO. Como resultados da pesquisa foram identificados que houveram poucas mudanças do pré para o pós teste no que se refere ao compartilhamento de itens pessoais, visto que os idosos compreendem que pode haver riscos de contaminação por agentes biológicos como vírus; quanto á preocupação com a saúde bucal a maioria sabiam dos riscos de desenvolver cárie ou placas bacterianas e se não houver cuidados com a boca e manutenção de prática saudável, como escovação periódica e uso do fio dental pode acarretar doenças. Quanto as condições socioeconômicas, os resultados foram bem similares com outros estudos, apontando que as condições financeiras mínimas podem afetar no autocuidado gerando prejuízos mentais, sociais e afetar diretamente a autonomia dos idosos. Conclui-se, que existe a necessidade em continuar com ações educativas para os idosos da Universidade da Maturidade, visto que as ações apresentam resultados positivos no que se refere ao autocuidado, mas que também é necessário compreender que as limitações impostas pelo envelhecimento, como as condições socioeconômicas e baixa escolaridade que são considerados desafios enfrentados pela população idosa.
Wood-Derived Vascular Patches Loaded With Rapamycin Inhibit Neointimal Hyperplasia
Authors: Xie Boao , Zhang Liwei , Lou Chunyang , Wei Shunbo , Li Jing’an , Bai Hualong , Dardik Alan 
Published: July 2022

Background: Patches are commonly used to close blood vessels after vascular surgery. Most currently used materials are either prosthetics or animal-derived; although natural materials, such as a leaf, can be used as a patch, healing of these natural materials is not optimal; rhodamine and rapamycin have been used to show that coating patches with drugs allow drug delivery to inhibit neointimal hyperplasia that may improve patch healing. Wood is abundant, and its stiffness can be reduced with processing; however, whether wood can be used as a vascular patch is not established. We hypothesized that wood can be used as a vascular patch and thus may serve as a novel plant-based biocompatible material.Method: Male Sprague–Dawley rats (aged 6–8 weeks) were used as an inferior vena cava (IVC) patch venoplasty model. After softening, wood patches coated with rhodamine and rapamycin were implanted into the rat subcutaneous tissue, the abdominal cavity, or the IVC. Samples were explanted on day 14 for analysis.Result: Wood patches became soft after processing. Patches showed biocompatibility after implantation into the subcutaneous tissue or the abdominal cavity. After implantation into the IVC, the patches retained mechanical strength. There was a significantly thinner neointima in wood patches coated with rapamycin than control patches (146.7 ± 15.32 μm vs. 524.7 ± 26.81 μm; p = 0.0001). There were CD34 and nestin-positive cells throughout the patch, and neointimal endothelial cells were Eph-B4 and COUP-TFII-positive. There was a significantly smaller number of PCNA and α-actin dual-positive cells in the neointima (p = 0.0003), peri-patch area (p = 0.0198), and adventitia (p = 0.0004) in wood patches coated with rapamycin than control patches. Piezo1 was expressed in the neointima and peri-patch area, and there were decreased CD68 and piezo1 dual-positive cells in wood patches coated with rapamycin compared to control patches.Conclusion: Wood can be used as a novel biomaterial that can be implanted as a vascular patch and also serve as a scaffold for drug delivery. Plant-derived materials may be an alternative to prosthetics or animal-based materials in vascular applications.
Saccharides Influence Sperm Quality and Expressions of Motility and Fertilization-Associated Genes in Cryopreserved Sperm of Pacific Abalone, Haliotis discus hannai
Authors: Hossen Shaharior , Sukhan Zahid Parvez , Cho Yusin , Choi Cheol Young , Kho Kang Hee 
Published: July 2022

Pacific abalone, Haliotis discus hannai, is a highly commercial seafood in Southeast Asia. The present study aimed to determine the influence of saccharides and vitamins on post-thaw sperm quality, ATP content, fertilization capacity, hatching capacity, and mRNA content of motility and fertilization-associated genes of Pacific abalone. Sperm cryopreserved using saccharides improved the post-thaw sperm quality including motility, acrosome integrity (AI), plasma membrane integrity (PMI), and mitochondrial membrane potential (MMP). However, vitamins (l-ascorbic acid) did not result in any significant improvement in sperm quality. Sperm cryopreserved using saccharides also improved ATP content, DNA integrity, and mRNA content of motility and fertilization-associated genes of post-thaw sperm than sperm cryopreserved without saccharides. Among sperm cryopreserved using different saccharides, post-thaw sperm quality indicators (except PMI) and mRNA content of motility and fertilization-associated genes did not show significant differences between sperm cryopreserved using 3% sucrose (S) combined with 8% dimethyl sulfoxide (DMSO) and sperm cryopreserved using 1% glucose (G) combined with 8% ethylene glycol (EG). However, sperm cryopreserved using 3% S + 8% DMSO showed higher post-thaw sperm quality (motility: 58.4 ± 2.9%, AI: 57.1 ± 3.2%, PMI: 65.3 ± 3.3%, and MMP: 59.1 ± 3.2%), ATP content (48.4 ± 1.8 nmol/ml), and % DNA in tail (2.09 ± 0.20%) than sperm cryopreserved using other saccharides. When sperms were cryopreserved using 3% S + 8% DMSO, the mRNA content of motility (heat shock protein 70, HSP70; heat shock protein 90, HSP90; protein kinase A, PKA-C; axonemal protein 66.0, Axpp66.0; and tektin-4) and fertilization-associated (sperm protein 18 kDa, SP18 kDa) genes were higher than in sperm cryopreserved using other saccharides. However, changes in the mRNA contents of these genes were insignificant between sperm cryopreserved using 3% S + 8% DMSO and 1% G + 8% EG. Taken together, these results indicate that cryopreservation using 3% S + 8% DMSO can improve post-thaw sperm quality and mRNA contents better than other examined cryoprotectants. The present study suggests that 3% S + 8% DMSO is a suitable cryoprotectant for sperm cryopreservation and molecular conservation of this valuable species.
Rational Design of Synergistic Structure Between Single-Atoms and Nanoparticles for CO2 Hydrogenation to Formate Under Ambient Conditions
Authors: Zhai Shengliang , Zhang Ling , Sun Jikai , Sun Lei , Jiang Shuchao , Yu Tie , Zhai Dong , Liu Chengcheng , Li Zhen , Ren Guoqing 
Published: July 2022

Single-atom catalysts (SACs) as the new frontier in heterogeneous catalysis have attracted increasing attention. However, the rational design of SACs with high catalytic activities for specified reactions still remains challenging. Herein, we report the rational design of a Pd1-PdNPs synergistic structure on 2,6-pyridinedicarbonitrile-derived covalent triazine framework (CTF) as an efficient active site for CO2 hydrogenation to formate under ambient conditions. Compared with the catalysts mainly comprising Pd1 and PdNPs, this hybrid catalyst presented significantly improved catalytic activity. By regulating the ratio of Pd1 to PdNPs, we obtained the optimal catalytic activity with a formate formation rate of 3.66 molHCOOM·molPd−1·h−1 under ambient conditions (30°C, 0.1 MPa). Moreover, as a heterogeneous catalyst, this hybrid catalyst is easily recovered and exhibits about a 20% decrease in the catalytic activity after five cycles. These findings are significant in elucidating new rational design principles for CO2 hydrogenation catalysts with superior activity and may open up the possibilities of converting CO2 under ambient conditions.
Association of Metabolic Dysfunction-Associated Fatty Liver Disease With Left Ventricular Diastolic Function and Cardiac Morphology
Authors: Peng Dandan , Yu Zhenqiu , Wang Mingwei , Shi Junping , Sun Lei , Zhang Yuanyuan , Zhao Wenbin , Chen Chen , Tang Jiake , Wang Chunyi , Ni Jie , Wen Wen , Jiang Jingjie 
Published: July 2022

Background and AimNon-alcoholic fatty liver disease (NAFLD) is closely related to cardiovascular diseases (CVD). A newly proposed definition is metabolic dysfunction-associated fatty liver disease (MAFLD), which was changed from NAFLD. The clinical effect of this change on abnormalities of cardiac structure and function is yet unknown. We aimed to examine whether MAFLD is associated with left ventricular (LV) diastolic dysfunction (LVDD) and cardiac remolding and further identify the impact of different subgroups and severity of MAFLD.MethodWe evaluated 228 participants without known CVDs. Participants were categorized by the presence of MAFLD and the normal group. Then, patients with MAFLD were subclassified into three subgroups: MAFLD patients with diabetes (diabetes subgroup), overweight/obesity patients (overweight/obesity subgroup), and lean/normal-weight patients who had two metabolic risk abnormalities (lean metabolic dysfunction subgroup). Furthermore, the severity of hepatic steatosis was assessed by transient elastography (FibroScan®) with a controlled attenuation parameter (CAP), and patients with MAFLD were divided into normal, mild, moderate, and severe hepatic steatosis groups based on CAP value. Cardiac structure and function were examined by echocardiography.ResultsLVDD was significantly more prevalent in the MAFLD group (24.6% vs. 60.8%, p &lt; 0.001) compared to the normal group. The overweight subgroup and diabetes subgroup were significantly associated with signs of cardiac remolding, including interventricular septum thickness, LV posterior wall thickness, left atrial diameter (all p &lt; 0.05), relative wall thickness, and LV mass index (all p &lt; 0.05). Additionally, moderate-to-to severe steatosis patients had higher risks for LVDD and cardiac remolding (all p-values &lt; 0.05).ConclusionMAFLD was associated with LVDD and cardiac remolding, especially in patients with diabetes, overweight patients, and moderate-to-to severe steatosis patients. This study provides theoretical support for the precise prevention of cardiovascular dysfunction in patients with MAFLD.
Online Control of Smart Inverter for Photovoltaic Power Generation Systems in a Smart Grid
Authors: Huang Kuo-Hua , Chao Kuei-Hsiang , Sun Zhi-Yao , Liao Yu-Hsiang 
Published: July 2022

The main purpose of this study is to engage in research on a grid-connected photovoltaic (PV) power generation system smart inverter. The research content includes a smart maximum power point tracking (MPPT) controller and an inverter with power regulation. First, use the PSIM software package to establish the simulation environment of the grid-connected photovoltaic power generation system and use the Sanyo HIP-186BA19 photovoltaic module to form a 744 W system for simulation. In order to enable the photovoltaic module array (PVMA) to output the maximum power under different solar insolation and ambient temperature, the architecture is based on the extension theory-based smart MPPT method to improve the dynamic response and steady-state performance of photovoltaic power generation systems compared to perturb and observed (P&amp;O) MPPT. When the sunshine is 1,000 W/m2, the photovoltaic power generation system adopts the extension theory-based maximum power tracking method. The time required to track the maximum power point is only 0.32 s, and the steady-state ripple is only 4.127 W. However, using the traditional P&amp;O method requires 0.741 s to track the maximum power point, and the steady-state ripple reaches 18.131 W. Thus, the dynamic response speed of the maximum power tracking method proposed is 50% faster than that of the P&amp;O method. The steady-state performance is also better compared to the P&amp;O method. At the same time, a simple proportional-integral (PI) controller is used to regulate the DC-link voltage, output voltage, and current of the inverter to make the voltage of the grid-connected point stable at an effective value of 220 V. Then, the voltage-power control technology is added to the photovoltaic grid-connected inverter, and a simple proportional-integral controller is used to regulate the output of the smart inverter reactive power to improve the power quality of grid voltage. Finally, simulation and experimental results are used to verify the effectiveness of the regulation performance of the developed smart inverter.
Soil Mapping Using Electromagnetic Induction to Assess the Suitability of Land for Growing Leptospermum nitens in Western Australia
Authors: Shaukat Hira , Flower Ken C. , Leopold Matthias 
Published: July 2022

Leptospermum sp. with dihydroxyacetone in their nectar are a source of high-value medicinal honey production and can provide income from agriculturally marginal lands. The current study was from two newly planted Leptospermum nitens sites, one with duplex soil and the other in deep sandy soil, in the low rainfall areas of the south-west of Western Australia, with the aim of identifying key soil parameters influencing the plantation’s survival and growth. Electromagnetic induction (EMI) at different depths was used to investigate the possible impact of soil variability on the Leptospermum nitens plantations. Two EMI surveys were conducted at each site, at different times of the year, to account for soil moisture variability (relatively dry and wet conditions). A least-square inversion algorithm was used to determine true electrical conductivities at three different soil depths (0–0.5, 0.5–0.8, and 0.8–1.6 m) to produce quasi-3D maps of soil inverted electrical conductivity. Corresponding soil samples from each depth were used for the physico-chemical analysis of soil parameters and to develop laboratory-based electrical resistivity to soil volumetric moisture calibrations with R2 values between 0.95 and 0.99. Shrub survival and growth (canopy diameter) were estimated using unmanned aerial vehicle (UAV) images and machine learning. Comparing EMI soil mapping with UAV imagery results showed significantly greater shrub survival and growth (p &lt; 0.001) in areas with higher ECa ranges of 12–24 mS m−1 at the variable textured site and 6–9 mS m−1 at the uniformly sandy site. Overall, the variable textured site, with an 82% survival rate, had a significantly higher shrub count and larger plants than the uniformly sandy site, with a 75% survival rate. A principal component analysis (PCA) identified inverted EC to be strongly correlated with soil moisture &gt; pH &gt; soil texture. Such soil mapping may be a robust and effective method for risk assessment of new shrub plantations.
Long-Term Intranasal Nerve Growth Factor Treatment Favors Neuron Formation in de novo Brain Tissue
Authors: Colitti Nina , Desmoulin Franck , Le Friec Alice , Labriji Wafae , Robert Lorenne , Michaux Amandine , Conchou Fabrice , Cirillo Carla , Loubinoux Isabelle 
Published: July 2022

ObjectiveTo date, no safe and effective pharmacological treatment has been clinically validated for improving post-stroke neurogenesis. Growth factors are good candidates but low safety has limited their application in the clinic. An additional restraint is the delivery route. Intranasal delivery presents many advantages.Materials and MethodsA brain lesion was induced in twenty-four rats. Nerve growth factor (NGF) 5 μg/kg/day or vehicle was given intranasally from day 10 post-lesion for two periods of five weeks, separated by a two-week wash out period with no treatment. Lesion volume and atrophy were identified by magnetic resonance imaging (MRI). Anxiety and sensorimotor recovery were measured by behavior tests. Neurogenesis, angiogenesis and inflammation were evaluated by histology at 12 weeks.ResultsRemarkable neurogenesis occurred and was visible at the second and third months after the insult. Tissue reconstruction was clearly detected by T2 weighted MRI at 8 and 12 weeks post-lesion and confirmed by histology. In the new tissue (8.1% of the lesion in the NGF group vs. 2.4%, in the control group at 12 weeks), NGF significantly increased the percentage of mature neurons (19% vs. 7%). Angiogenesis and inflammation were not different in the two groups. Sensorimotor recovery was neither improved nor hampered by NGF during the first period of treatment, but NGF treatment limited motor recovery in the second period.InterpretationThe first five-week period of treatment was very well tolerated. This study is the first presenting the effects of a long treatment with NGF and has shown an important tissue regeneration rate at 8 and 12 weeks post-injury. NGF may have increased neuronal differentiation and survival and favored neurogenesis and neuron survival through subventricular zone (SVZ) neurogenesis or reprogramming of reactive astrocytes. For the first time, we evidenced a MRI biomarker of neurogenesis and tissue reconstruction with T2 and diffusion weighted imaging.
Effect of high-protein vs. high-fat snacks before lunch on glycemic variability in prediabetes: A study protocol for a randomized controlled trial
Authors: Liu Yupeng , Jiang Huinan , Ruan Binye , Liu Yi , Le Siyu , Fu Xiaoyi , Wang Shuran 
Published: July 2022

BackgroundChina has the largest number of patients with Type 2 Diabetes Mellitus (T2DM), and it tends to increasingly grow in the future, putting an enormous burden on disease control and prevention in China. While glycemic variability (GV) came to be an important indicator of blood glucose control in diabetic patients, studies suggested that premeal snacks may help blood glucose control, but there are still some problems to be researched. Therefore, we designed this trial to evaluate which kind of premeal snacks would lead to better effects on GV under two diet patterns in pre-diabetes subjects and to evaluate assessments of acceptability and compliance, behavior, and metabolism changes in individuals will be described.Methods and analysisThe study is a single-center, open-label, multiparallel group, randomized controlled trial. A total of 32 male and female volunteers will be randomized into 4 groups in a single allocated ratio of soy milk (powder) snack, milk (powder) snack, almonds snack, and placebo control with 250 ml of water taken 30 min before lunch, respectively. The study consists of two intervention periods over 11 days. The first intervention period under habitual diet conditions from D3 to D6 (4 days), during which all subjects are asked to maintain their habitual eating and daily activities similar to the run-in period. The second intervention consists of prelunch snacks with standard meals. We will examine both the effect of GV and various metabolic and behavioral outcomes potentially associated with the interventions. At the end of this study, we will assess the acceptability and maintainability of the intervention through interviews.Clinical trial registrationChinese Clinical Trial Registry, identifier ChiCTR2200058935.
Differences in post-traumatic growth: Individual quarantine, COVID-19 duration and gender
Authors: Cohen-Louck Keren 
Published: July 2022

ObjectiveThis study focuses on positive effects of the COVID-19 pandemic and aims to identify associations between gender, individual quarantine and duration of the COVID-19 (short- medium- and long-term pandemic), and posttraumatic growth (PTG).MethodThe data was collected via an online survey in Israel, and included 1,301 participants, 543 participants experienced short-term pandemics, 428 participants experienced medium-term pandemics and 330 participants experienced long-term pandemics. Most of the participants were female (73.6%), ranging from 18 to 89 years-old. The participants answered questions about their demographic background, individual quarantine experiences and ranked their PTG level.ResultsThe results indicate a significant main effect of gender and pandemic duration (short-, medium- and long-term pandemic). Women reported higher PTG levels than men, and participants experiencing short-term pandemic reported significantly lower PTG levels than participants experiencing medium- or long-term pandemic. There was also a significant interaction between gender and pandemic duration regarding PTG and a significant interaction in PTG by gender, pandemic duration and individual quarantine.ConclusionThe discussion addresses the findings in the context of traditional gender roles and gender differences in finding meaning and worth in home confinement situations.
Quality and quantity of serious violent suicide attempts during the COVID-19 pandemic
Authors: Maleitzke Tazio , Zocholl Dario , Topp Tobias , Dimitrov-Discher Annika , Daus Elly , Reaux Gabriel , Zocholl Malin , Conze Rolf Nicolas , Kolster Moritz , Weber Philipp , Fleckenstein Florian Nima , Scheutz Henriksen Louise , Stöckle Ulrich , Fuchs Thomas , Gümbel Denis , Spranger Nikolai , Ringk Alexander , Märdian Sven 
Published: July 2022

BackgroundWhile repeated shutdown and lockdown measures helped contain the spread of SARS-CoV-2 during the COVID-19 pandemic, social distancing and self-isolation negatively impacted global mental health in 2020 and 2021. Although suicide rates did reportedly not increase during the first months of the pandemic, long-term data, and data on the quality of serious violent suicide attempts (SVSAs) are not available to date.Materials and methodsOrthopaedic trauma patient visits to the emergency department (ED), ED trauma team activations, and SVSAs were retrospectively evaluated from January 2019 until May 2021 in four Level-I Trauma Centers in Berlin, Germany. SVSAs were assessed for suicide method, injury pattern and severity, type of treatment, and length of hospital stay.ResultsSignificantly fewer orthopaedic trauma patients presented to EDs during the pandemic (n = 70,271) compared to the control (n = 84,864) period (p = 0.0017). ED trauma team activation numbers remained unchanged. SVSAs (corrected for seasonality) also remained unchanged during control (n = 138) and pandemic (n = 129) periods, and no differences were observed for suicide methods, injury patterns, or length of hospital stay.ConclusionOur data emphasize that a previously reported rise in psychological stress during the COVID-19 pandemic does not coincide with increased SVSA rates or changes in quality of SVSAs.