bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling nearest neighbour distributions of biased tracers using hybrid effective field theory
Authors: Banerjee Arka , Kokron Nickolas , Abel Tom 
Published: January 2022

ABSTRACT
We investigate the application of hybrid effective field theory (HEFT) – which combines a Lagrangian bias expansion with subsequent particle dynamics from N-body simulations – to the modelling of k-nearest neighbour cumulative distribution functions (kNN-CDFs) of biased tracers of the cosmological matter field. The kNN-CDFs are sensitive to all higher order connected N-point functions in the data, but are computationally cheap to compute. We develop the formalism to predict the kNN-CDFs of discrete tracers of a continuous field from the statistics of the continuous field itself. Using this formalism, we demonstrate how kNN-CDF statistics of a set of biased tracers, such as haloes or galaxies, of the cosmological matter field can be modelled given a set of low-redshift HEFT component fields and bias parameter values. These are the same ingredients needed to predict the two-point clustering. For a specific sample of haloes, we show that both the two-point clustering and the kNN-CDFs can be well-fit on quasi-linear scales (≳ 20h−1Mpc) by the second-order HEFT formalism with the same values of the bias parameters, implying that joint modelling of the two is possible. Finally, using a Fisher matrix analysis, we show that including kNN-CDF measurements over the range of allowed scales in the HEFT framework can improve the constraints on σ8 by roughly a factor of 3, compared to the case where only two-point measurements are considered. Combining the statistical power of kNN measurements with the modelling power of HEFT, therefore, represents an exciting prospect for extracting greater information from small-scale cosmological clustering.
Effect of Nitinol surface with nanotubes and/or ordered nanopores on cell behavior
Authors: Vrchovecká Kateřina , Mrázková Jana , Pávková Goldbergová Monika 
Published: January 2022

AbstractRecent medical applications have specific requirements on materials and Nitinol can fulfill them due to its exceptional characteristics, which can be further improved by modifications of the material surface. Various surface nanostructuring methods are utilized to enhance characteristics of oxide layer, which naturally develops on the Nitinol surface, leading to improved biocompatibility and corrosion resistance. This review is focused on studies investigating the behavior of various cell types on surface nanotubes and ordered nanopores prepared by anodic oxidation, a technique allowing fabrication of nanostructures with defined parameters. Results showed that certain dimensions of nanotubes positively affect adhesion and viability of osteoblasts and endothelial cells on the surface, contrary to negative effect on smooth muscle cells, both required by the medical applications. Furthermore, increased antibacterial effect correlated with the nanostructure topography and release rates of Ni ions.
Sociodemographic Disparities in Tobacco Retailer Density in the United States, 2000–2017
Authors: Mills Sarah D , Kong Amanda Y , Reimold Alexandria E , Baggett Chris D , Wiesen Christopher A , Golden Shelley D 
Published: January 2022

Abstract

Introduction
Studies find differences in tobacco retailer density according to neighborhood sociodemographic characteristics, raising issues of social justice, but not all research is consistent.

Aims and Methods
This study examined associations between tobacco retailer density and neighborhood sociodemographic characteristics in the United States at four timepoints (2000, 2007, 2012, and 2017) and investigated if associations remained stable over time. Data on tobacco retailers came from the National Establishment Time-Series Database. Adjusted log-linear models examined the relationship between retailer density and census tract sociodemographic characteristics (% non-Hispanic Black [Black], % Hispanic, % vacant housing units, median household income), controlling for percentage of youth, urbanicity, and US region. To examine whether the relationship between density and sociodemographic characteristics changed over time, additional models were estimated with interaction terms between each sociodemographic characteristic and year.

Results
Tobacco retailer density ranged from 1.22 to 1.44 retailers/1000 persons from 2000 to 2017. There were significant, positive relationships between tobacco retailer density and the percentage of Black (standardized exp(b) = 1.05 [95% CI: 1.04% to 1.07%]) and Hispanic (standardized exp(b) = 1.06 [95% CI: 1.05% to 1.08%]) residents and the percentage of vacant housing units (standardized exp(b) =1.08 [95% CI: 1.07% to 1.10%]) in a census tract. Retailer density was negatively associated with income (standardized exp(b) = 0.84 [95% CI: 0.82% to 0.86%]). From 2000 to 2017, the relationship between retailer density and income and vacant housing units became weaker.

Conclusions
Despite the weakening of some associations, there are sociodemographic disparities in tobacco retailer density from 2000 to 2017, which research has shown may contribute to inequities in smoking.

Implications
This study examines associations between tobacco retailer density and neighborhood sociodemographic characteristics in the United States at four timepoints from 2000 to 2017. Although some associations weakened, there are sociodemographic disparities in tobacco retailer density over the study period. Research suggests that sociodemographic disparities in retailer density may contribute to inequities in smoking. Findings from this study may help identify which communities should be prioritized for policy intervention and regulation.
MdWRKY126 modulates malate accumulation in apple fruit by regulating cytosolic malate dehydrogenase (MdMDH5)
Authors: Zhang Lihua , Ma Baiquan , Wang Changzhi , Chen Xingyu , Ruan Yong-Ling , Yuan Yangyang , Ma Fengwang , Li Mingjun 
Published: January 2022

AbstractThe content of organic acids greatly influences the taste and storage life of fleshy fruit. Our current understanding of the molecular mechanism of organic acid accumulation in apple (Malus domestica) fruit focuses on the aluminum-activated malate transporter 9/Ma1 gene. In this study, we identified a candidate gene, MdWRKY126, for controlling fruit acidity independent of Ma1 using homozygous recessive mutants of Ma1, namely Belle de Boskoop “BSKP” and Aifeng “AF.” Analyses of transgenic apple calli and flesh and tomato (Solanum lycopersicum) fruit demonstrated that MdWRKY126 was substantially associated with malate content. MdWRKY126 was directly bound to the promoter of the cytoplasmic NAD-dependent malate dehydrogenase MdMDH5 and promoted its expression, thereby enhancing the malate content of apple fruit. In MdWRKY126 overexpressing calli, the mRNA levels of malate-associated transporters and proton pump genes also significantly increased, which contributed to the transport of malate accumulated in the cytoplasm to the vacuole. These findings demonstrated that MdWRKY126 regulates malate anabolism in the cytoplasm and coordinates the transport between cytoplasm and vacuole to regulate malate accumulation. Our study provides useful information to improve our understanding of the complex mechanism regulating apple fruit acidity.
Autophagy is required for self-incompatible pollen rejection in two transgenic Arabidopsis thaliana accessions
Authors: Macgregor Stuart R , Lee Hyun Kyung , Nelles Hayley , Johnson Daniel C , Zhang Tong , Ma Chaozhi , Goring Daphne R 
Published: January 2022

Abstract
Successful reproduction in the Brassicaceae is mediated by a complex series of interactions between the pollen and the pistil, and some species have an additional layer of regulation with the self-incompatibility trait. While the initial activation of the self-incompatibility pathway by the pollen S-locus protein 11/S locus cysteine-rich protein and the stigma S Receptor Kinase is well characterized, the downstream mechanisms causing self-pollen rejection are still not fully understood. In previous studies, we detected the presence of autophagic bodies with self-incompatible (SI) pollinations in Arabidopsis lyrata and transgenic Arabidopsis thaliana lines, but whether autophagy was essential for self-pollen rejection was unknown. Here, we investigated the requirement of autophagy in this response by crossing mutations in the essential AUTOPHAGY7 (ATG7) and ATG5 genes into two different transgenic SI A. thaliana lines in the Col-0 and C24 accessions. By using these previously characterized transgenic lines that express A. lyrata and Arabidopsis halleri self-incompatibility genes, we demonstrated that disrupting autophagy weakened their SI responses in the stigma. When the atg7 or atg5 mutations were present, an increased number of SI pollen was found to hydrate and form pollen tubes that successfully fertilized the SI pistils. Additionally, we confirmed the presence of GFP-ATG8a-labeled autophagosomes in the stigmatic papillae following SI pollinations. Together, these findings support the requirement of autophagy in the self-incompatibility response and add to the growing understanding of the intracellular mechanisms employed in the transgenic A. thaliana stigmas to reject self-pollen.
Shedding Light on the Dark Figure of Police Mental Health Calls for Service
Authors: Koziarski Jacek , Ferguson Lorna , Huey Laura 
Published: January 2022

AbstractRecent discussions around police reform have acquired a significant degree of traction. Within these discussions have been calls to remove the police as primary responders to calls involving persons with perceived mental illness (PwPMI). While previous research shows that ∼1% of all calls for service involve PwPMI, limitations around police data recording practices likely mask the true proportion of PwPMI within and across calls for service. Accordingly, following manual review and text search of qualitative data appended to all calls for service made to a Canadian police service in 2019, we sought to identify the true proportion of calls for police service that involve PwPMI and predict the extent to which PwPMI are involved within and across different call classifications. Our findings reveal that while the ‘Mental Health’ call classification only comprised 0.9% (n = 397) of calls for service, PwPMI were in fact involved in 10.8% (n = 4,646) of calls. Furthermore, logistic regression models reveal that PwPMI are more likely to be involved in certain call classifications relative to others. Implications for police practice and reform are discussed.
Scope and convergence of the hopping parameter expansion in finite-temperature quantum chromodynamics with heavy quarks around the critical point
Authors: Wakabayashi Naoki , Ejiri Shinji , Kanaya Kazuyuki , Kitazawa Masakiyo 
Published: January 2022

Abstract
Hopping parameter expansion is a useful tool for investigating heavy dynamical quarks in lattice quantum chromodynamics (QCD), though its range of applicability has sometimes been questioned. We study the convergence and the valid range of the hopping parameter expansion in determining the critical point (critical quark mass) of QCD with heavy quarks at finite temperature and density. On lattices with sufficiently large spatial extent, the terms in the hopping parameter expansion are classified into Wilson loop terms and Polyakov-type loop terms. We first study the case of the worst convergence in which all the gauge link variables are unit matrices and thus the Wilson loops and the Polyakov-type loops get their maximum values. We perform explicit calculation up to more than the 100th order of the hopping parameter expansion. We show that the hopping parameter expansion is convergent up to the chiral limit of free Wilson quarks. We then perform a Monte Carlo simulation to measure correlation among Polyakov-type loop terms up to the 20th order of the hopping parameter expansion. In previous studies, strong correlation between the leading-order Polyakov loop term and the next-to-leading-order bent Polyakov loop terms was reported and used to construct an effective theory to incorporate the next-to-leading-order effect by a shift of the leading-order coupling parameter. We establish that the strong correlation among Polyakov-type loop terms also holds at higher orders of the hopping parameter expansion, and extend the effective theory to incorporate higher-order effects up to high orders. Using the effective theory, we study the truncation error of the hopping parameter expansion. We find that the previous next-to-leading-order result for the critical point for Nt = 4 is reliable. For Nt ≥ 6, we need to incorporate higher-order effects in the effective theory.
Bear Beta or Speculative Beta?—Reconciling the Evidence on Downside Risk Premium
Authors: Wang Tong 
Published: January 2022

Abstract
This article develops a new approach to explain why risk factors constructed from index option returns are priced in the stock market. We decompose an option-based factor into three main components and identify the one responsible for the beta–return relationship. Applying this method to the bear risk factor proposed by Lu and Murray reveals that the negative correlation between bear betas and stock returns does not reflect systematic risk premia. Instead, it represents an anomaly closely related to the betting-against-beta puzzle. We trace the root of this anomaly to disagreement concerning the aggregate stock market. Our work reconciles the conflicting evidence concerning downside risk by showing that neither ex-post nor ex-ante downside risk is priced in the cross-section of stocks while making a methodological contribution that facilitates more accurate interpretation of option-based risk factors in future research.
Neural correlates of successful costly punishment in the Ultimatum game on a trial-by-trial basis
Authors: Mussel Patrick , Weiß Martin , Rodrigues Johannes , Heekeren Hauke , Hewig Johannes 
Published: January 2022

AbstractCostly punishment describes decisions of an interaction partner to punish an opponent for violating rules of fairness at the expense of personal costs. Here, we extend the interaction process by investigating the impact of a socio-emotional reaction of the opponent in response to the punishment that indicates whether punishment was successful or not. In a modified Ultimatum game, emotional facial expressions of the proposer in response to the decision of the responder served as feedback stimuli. We found that both honored reward following acceptance of an offer (smiling compared to neutral facial expression) and successful punishment (sad compared to neutral facial expression) elicited a reward positivity, indicating that punishment was the intended outcome. By comparing the pattern of results with a probabilistic learning task, we show that the reward positivity on sad facial expressions was specific for the context of costly punishment. Additionally, acceptance rates on a trial-by-trial basis were altered according to P3 amplitudes in response to the emotional facial reaction of the proposer. Our results are in line with the concept of costly punishment as an intentional act following norm-violating behavior. Socio-emotional stimuli have an important influence on the perception and behavior in economic bargaining.
Mean platelet volume as a predictor of platelet count recovery in dengue patients
Authors: Martínez-Ruíz Diana Marcela , Tovar-Rios Diego Alejandro , Valencia-Orozco Andrea , Florez-Elvira Liliana Janeth , Agudelo Olga Lucia , Parra-Lara Luis Gabriel , Rosso Fernando 
Published: January 2022

Abstract

Background
Thrombocytopenia is a marker of severity in dengue, and its resolution predicts clinical improvement. The objective was to evaluate mean platelet volume (MPV) trajectories as a predictor of platelet count (PC) recovery in dengue patients.

Methods
An observational, longitudinal and analytical study was conducted at Fundación Valle del Lili (Cali, Colombia). Patients diagnosed with dengue during 2016–2020 were included. The association between PC and the covariates was evaluated using simple linear, quadratic and non-parametric spline smoothing regression models. A longitudinal linear mixed model was adjusted and then validated for PC measurements.

Results
A total of 71 patients were included. The median age was 27 y, 38.5% were women and half had dengue with warning signs. A statistically significant PC decrease was observed when MPV was 13.87 fL and 4.46 d from the onset of symptoms, while PC displayed a significant constant increase with neutrophils count. Then, PC recovery was achieved with an MPV of 13.58 fL, 4.5 d from the onset of symptoms and a minimum neutrophils count of 150 μL.

Conclusion
MPV may be a predictor of PC recovery in dengue patients. PC recovery is expected when a patient has an MPV of 13.58 fL, an onset time of 4.5 d and a neutrophils count of 150 μL.
Development of a Diagnostic Assay for Differentiation Between Genetic Groups in Clades I, II, III, and IV of Puccinia graminis f. sp. tritici
Authors: Szabo Les J. , Olivera Pablo D. , Wanyera Ruth , Visser Botma , Jin Yue 
Published: January 2022

Wheat stem rust has reemerged as a serious disease caused by new variants of Puccinia graminis f. sp. tritici. Variants with significant virulence and broad geographic distribution (Africa, Central Asia, and Europe) include the Ug99 race group, race TTRTF, and TKTTF race group. Genetic analysis has placed isolates representing these critical new virulent races into 12 genetic groups that make up clades I to IV. Development of molecular diagnostic assays for these 12 genetic groups will be an important component of global surveillance efforts. A single-nucleotide polymorphism database was mined for candidate markers that would differentiate between these 12 genetic groups. Thirty-five candidate markers were screened, and a core set of 17 markers was tested against a set of 94 isolates representing a broad range of genotypes and race phenotypes. These core markers were 100% accurate in identifying the 12 genetic groups for 52 isolates in clades I to IV, and no false positives were observed with nontarget isolates. The assay has built-in redundancy so that minor genetic changes or errors in genotyping calling will not affect the accuracy of the results. This assay is also effective in identifying the genetic groups in clade V from Germany and Georgia, the three main subgroups in North American clade VI, and clade VII consisting of race TTTTF found in North and South America. This assay provides a rapid diagnostic tool for both living and nonliving samples to detect these critical new races or race groups of P. graminis f. sp. tritici. [Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Control of Phoma Leaf Spot and Root Decay of Table Beet in New York
Authors: Pethybridge Sarah J. , Murphy Sean , Hay Frank , Branch Eric , Sharma Pratibha , Kikkert Julie R. 
Published: January 2022

Disease caused by Neocamarosporium betae (syn. Phoma betae, Pleospora betae) results in reductions in plant populations, foliar disease (Phoma leaf spot [PLS]), and root disease and decay in table beet. Disease caused by N. betae has reemerged as prevalent in organic table beet production in New York. The disease can also cause substantial issues in conventional table beet production. To evaluate in-field control options for conventional and organic table beet production, small-plot, replicated trials were conducted in each of two years (2019 and 2021). The fungicides, propiconazole and difenoconazole, and premixtures, pydiflumetofen + fludioxonil or pydiflumetofen + difenoconazole, provided excellent PLS and root decay control. Azoxystrobin provided excellent (69.9%) control of PLS in 2019 and lesser (40%) control in 2021. Field trial results complemented in vitro sensitivity testing of 30 New York N. betae isolates that were all highly sensitive to azoxystrobin (mean effective concentration to reduce mycelial growth by 50%, EC50= 0.0205 µg/ml) and propiconazole (mean EC50= 0.0638 µg/ml). Copper octanoate and microbial biopesticides containing either Bacillus amyloliquefaciens D747 or B. mycoides strain J provided moderate (68.5 to 74.6%) PLS control as reflected in epidemic progress. The Gompertz model provided the best fit to PLS epidemics reflecting a polycyclic epidemic. Reductions in PLS severity were associated with significant decreases in Phoma root decay and increases in canopy health and the time-to-death of leaves compared with nontreated control plots. Prolonging leaf survival is critical for mechanical harvest of roots. These findings underpin the design of programs for foliar disease control in conventional and organic table beet production. Assessment of PLS severity in the field will better inform postharvest management decisions.
Plasmodiophora brassicae in Mexico: From Anecdote to Fact
Authors: Padrón-Rodríguez Legnara , Cerdán Cabrera Carlos Roberto , Sánchez Coello Nadia Guadalupe , Luna-Rodríguez Mauricio , Pérez-López Edel 
Published: January 2022

For years, the presence of clubroot disease and its causal agent, Plasmodiophora brassicae, in Mexico has been stated as a fact. However, an intensive search of the scientific literature in English and Spanish, as well as gray literature including theses and government reports, did not reveal any information about the actual detection of the pathogen, affected hosts, or areas with clubroot presence, or any information about clubroot (hernia de la col in Mexico). We followed a multistep process to confirm whether P. brassicae was indeed in Mexico. First, we identified agricultural communities with a history of cruciferous crop cultivation. Second, we asked growers if they had seen clubroot on their crops, using pictures of the characteristic root galls. Third, we collected soil from the locations where clubroot was reported and looked for clubroot/P. brassicae in the soil using several cruciferous bait plants. For the first time we confirm the presence of the clubroot pathogen P. brassicae in Mexico, through a bioassay, the presence of resting spores, and a P. brassicae-specific PCR assay. The identification of P. brassicae in Mexico will contribute to our understanding of the genetic diversity of this elusive and devastating plant pathogen in future studies. [Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .