bluuebunny/crossref_metadata_2025_split huggingface dataset:
DANCER: Study protocol of a prospective, non-randomized controlled trial for crossed limb versus standard limb configuration in endovascular abdominal aortic aneurysm repair
Authors: Shen Yinzhi , Wang Jiarong , Zhao Jichun , Yuan Ding , Wang Tiehao , Huang Bin 
Published: November 2022

BackgroundHostile anatomy, especially severely angulated neck and tortuous iliac arteries, has always been a conundrum in endovascular aneurysm repair (EVAR). Crossed limb (CL) graft, also called the “ballerina technique,” has been utilized to address this problem by facilitating gate cannulation. In terms of short and long-term outcomes, correlated studies have made inconsistent conclusions and this issue remains controversial. Based on a previous cohort study conducted in our center, we aim to prospectively compare the safety and efficacy between CL and standard limb (SL) configuration in patients receiving EVAR.MethodsThis is a prospective, single-center, non-randomized controlled trial. A total of 275 patients who meet the inclusion criteria will be enrolled and allocated with a 4:11 ratio of CL to SL, which is based on results of our previous study. All patients will receive same perioperative management and postoperative medications. All EVAR procedures will be performed under standard protocol, utilizing Endurant II or IIs Stent Graft. The configuration of the graft stent will be decided by surgeons and confirmed by final angiography. The primary outcome is 3-year freedom from major adverse limb-graft events (MALEs). Endpoints will be assessed at the following time points: 1, 6, 12, 24, and 36 months.DiscussionTo our best knowledge, this crosseD vs. stANdard Configuration in Endovascular Repair (DANCER) trial is the first non-randomized controlled trial to compare these two graft configurations in EVAR. The main aim is to compare the MALEs between two groups at 3 years postoperatively. This trial will hopefully provide high-level evidence for employing CL in EVAR.Clinical trial registration[www.chictr.org.cn], identifier [ChiCTR2100053055].
Use of fibrates is not associated with reduced risks of mortality or cardiovascular events among ESRD patients: A national cohort study
Authors: Ho Wen-Yu , Yen Chieh-Li , Lee Cheng-Chia , Tu Yi-Ran , Chen Chao-Yu , Hsiao Ching-Chung , Chu Pao-Hsien , Hsu Hsiang-Hao , Tian Ya-Chun , Chang Chih-Hsiang 
Published: November 2022

BackgroundAlthough a recent study reported that fibrates are associated with a low risk of cardiovascular (CV) death and can postpone the need for long-term hemodialysis in patients with advanced chronic kidney disease (CKD), little is known regarding whether the CV protective effects of fibrates extend to patients with end-stage renal disease (ESRD). The present study compared CV outcomes and mortality among patients with ESRD treated with fibrates, statins, neither, or their combination.MethodsThis cohort study extracted data from Taiwan's National Health Insurance Research Database (NHIRD). Adult patients with ESRD and hyperlipidemia were identified and categorized into four groups (fibrate, statin, combination, and non-user groups) according to their use of different lipid-lowering therapies within 3 months prior to the commencement of permanent dialysis. Inverse probability of treatment weighting was used to balance the baseline characteristics of the groups. The follow-up outcomes were all-cause mortality, CV death, and major adverse cardiac and cerebrovascular events (MACCEs).ResultsCompared with the non-user and statin groups, the fibrate group did not exhibit significantly lower risks of all-cause mortality [fibrate vs. non-user: hazard ratio (HR), 0.97; 95% confidence interval (CI), 0.92–1.03; statin vs. fibrate: HR, 0.95; 95% CI, 0.90–1.01], CV death (fibrate vs. non-user: HR, 0.97; 95% CI, 0.90–1.05; statin vs. fibrate: HR, 0.97; 95% CI, 0.90–1.06), and MACCEs (fibrate vs. non-user: HR, 1.03; 95% CI, 0.96–1.10; statin vs. fibrate: HR, 0.94; 95% CI, 0.87–1.004). The combination of fibrates and statins (specifically moderate- to high-potency statins) did not result in lower risks of all-cause mortality, CV death, or MACCEs compared with statins alone.ConclusionIn patients with ESRD, the use of fibrates might be not associated with reduced mortality or CV risks, regardless of whether they are used alone or in combination with statins.
Duchenne muscular dystrophy involves the myocardium and causes arrhythmia: Case report
Authors: Liu Xuhan , Zhao Wei , Shu Shangzhi , Zhang Weihua 
Published: November 2022

BackgroundPatients with muscular dystrophy have mutations in the gene that can lead to severe muscle wasting, respiratory issues or heart failure between ages 30 and 40. Currently, there is no effective treatment for DMD-induced heart failure.Case presentationWe report a patient with recurrent unexplained fever and muscle soreness was definitely diagnosed with DMD. An analysis of the patient's genetics revealed a nonsense mutation (C.1207G &gt; T). His DMD was treated with hormones. Also, the patient's fever is under control because of hormone therapy. However, as the disease progresses, the heart structure and function gradually change, and eventually malignant arrhythmias occur.ConclusionWe report a rare case of DMD involving the heart causing heart failure and malignant arrhythmia. Currently, no complete treatment is available for these patients, but our treatment regimen may benefit our patient and improve his outcomes.
Construction and validation of an immune-related genes prognostic index (IRGPI) model in colon cancer
Authors: Jin Yabin , Deng Jianzhong , Luo Bing , Zhong Yubo , Yu Si 
Published: November 2022

BackgroundThough immunotherapy has become one of the standard therapies for colon cancer, the overall effective rate of immunotherapy is very low. Constructing an immune-related genes prognostic index (IRGPI) model may help to predict the response to immunotherapy and clinical outcomes.MethodsDifferentially expressed immune-related genes (DEIRGs) between normal tissues and colon cancer tissues were identified and used to construct the co-expression network. Genes in the module with the most significant differences were further analyzed. Independent prognostic immune-related genes (IRGs) were identified by univariate and multivariate cox regression analysis. Independent prognostic IRGs were used to construct the IRGPI model using the multivariate cox proportional hazards regression model, and the IRGPI model was validated by independent dataset. ROC curves were plotted and AUCs were calculated to estimate the predictive power of the IRGPI model to prognosis. Gene set enrichment analysis (GSEA) was performed to screen the enriched KEGG pathways in the high-risk and low-risk phenotype. Correlations between IRGPI and clinical characteristic, immune checkpoint expression, TMB, immune cell infiltration, immune function, immune dysfunction, immune exclusion, immune subtype were analyzed.ResultsTotally 680 DEIRGs were identified. Three independent IRGs,NR5A2, PPARGC1A and LGALS4, were independently related to survival. NR5A2, PPARGC1A and LGALS4 were used to establish the IRGPI model. Survival analysis showed that patients with high-risk showed worse survival than patients in the low-risk group. The AUC of the IRGPI model for 1-year, 3-year and 5-year were 0.584, 0.608 and 0.697, respectively. Univariate analysis and multivariate cox regression analysis indicated that IRGPI were independent prognostic factors for survival. Stratified survival analysis showed that patients with IRGPI low-risk and low TMB had the best survival, which suggested that combination of TMB and IRGPI can better predict clinical outcome. Immune cell infiltration, immune function, immune checkpoint expression and immune exclusion were different between IRGPI high-risk and low-risk patients.ConclusionAn immune-related genes prognostic index (IRGPI) was constructed and validated in the current study and the IRGPI maybe a potential biomarker for evaluating response to immunotherapy and clinical outcome for colon cancer patients.
Analysis of macular structure in age-related cataract patients with different antibody levels of severe acute respiratory syndrome coronavirus-2 vaccine
Authors: Li Xiaochun , Cao Xiaoguang , Pan Zhongting , Sun Xinping , Bao Yongzhen 
Published: November 2022

ObjectiveTo analyze the macular structure of age-related cataract (ARC) patients with different antibody levels after COVID-19 vaccine injection, in order to obtain the effect of COVID-19 vaccine on the macular structure, and speculate whether the COVID-19 vaccine has adverse effects on the macular structure.MethodsThis retrospective study is conducted to analysis on the status of COVID-19 vaccine and the thickness of different layers at different positions in the macular area of ARC patients. In the age, sex and eye axial length matched population, in the un-injection, no-antibody, IgM and IgG positive groups after vaccination, the choroid, ganglion cell complex, nerve fiber layer and retinal thickness at different positions of ETDRS zoning in the macular area were discussed.ResultsA total of 164 patients (164 eyes) were included in the analysis. There were 63 males and 101 females. The average age was 65.99 ± 8.43 years. There was no significant difference in age and sex among the groups (p&gt;0.05). The average axial length of 164 eyes was 23.56 ± 1.46mm, and no significant difference between the groups (p&gt;0.05). Non parametric test and ANOVA test for the thickness of choroid, retina, ganglion cell complex and retinal nerve fiber layer in each division of ETDRS showed no significant difference in the four groups of un-injection, no-antibody, IgM and IgG (p&gt;0.05). There was no correlation between the antibody concentration and the thickness of macular structure (p&gt;0.05).ConclusionThere was no significant difference in the thickness of choroid, retina, ganglion cell complex and retinal fiber layer in different macular areas after COVID-19 vaccine injection. There was no linear correlation between the thickness of choroid, retina, ganglion cell complex and retinal fiber layer and the antibody concentration produced after COVID-19 vaccine injection. It suggests that the injection of COVID-19 vaccine might have no significant effect on the macular structure of eye.
Taxonomy and phylogeny of Pseudovorticella ciliates (Ciliophora, Peritrichia): Two new and one rare species from the coastal waters of China
Authors: Zhang Yong , Yu Ying , Qu Zhishuai , Jiang Mengmeng , Shen Zhuo , Li Jiqiu , Lin Xiaofeng 
Published: November 2022

Peritrich ciliates are a species-rich group of sessile unicellular eukaryotes, which can be found in various aquatic habitats from all over the world. It is well accepted that there are still many ciliates to be uncovered. During a survey on ciliate biodiversity in the coastal waters of China, three solitary peritrich species were identified as members of the genus Pseudovorticella Foissner &amp; Schiffmann, 1975, including two new species and a rare one. Pseudovorticella zhejiangensis sp. n. differs from its congeners mainly by having a conical-shaped zooid, conspicuous pellicular blisters, one ventral and one dorsal contractile vacuoles, and an infundibular polykinety 3 with three rows of nearly equal length but different beginning positions. Pseudovorticella dalianensis sp. n. can be defined mainly by an obovoid-shaped zooid, one ventral contractile vacuole, and a three-rowed infundibular polykinety 3 with the middle row being the longest. The rare species, Pseudovorticella verrucosa (Dons, 1915) Sun et al., 2009, was redescribed. The small subunit (SSU) rDNA sequences of these three species were sequenced for the first time, the phylogeny of Pseudovorticella species was analyzed, and the results verified the non-monophyly of this genus. This study demonstrates that the morphologic and gene barcoding data are the optimum combination to disclose the biodiversity of ciliates.
Reproductive cycle of the female Anisotremus scapularis (Tschudi, 1846) on the marine coast of Callao, basic knowledge to go towards its aquaculture
Authors: Carrera Santos Lili J. , Fontes Jéssica G. , Santos Gustavo R. Cardoso Dos , Padilha Mônica Costa , Opazo Rafael 
Published: November 2022

Anisotremus scapularis is an important commercial species in Perú, being a prioritized species for the development of its aquaculture. The aim of the study was to establish the A. scapularis female reproductive cycle and reproductive strategy on the marine coast of Callao, through a seasonal sampling of wild specimens. The specimen collection was carried out between January 2019 to December 2020. Eighty-one female specimens were collected, and biometric indices were calculated such as condition factor (K) or gonadosomatic index (GSI), among others. The phases of the reproductive cycle were established by ovary histology in association with a steroid profile analysis performed by GC-EI-MS/MS. The reproductive strategy of A. scapularis was classified as asynchronous spawning with indeterminate fecundity. The average size at first maturity calculated as L100 was 25.3 cm. The GSI distribution was significantly higher in the specimens collected in summer than in the specimens collected in other seasons. The plasma concentration of 17β-estradiol, androstenedione-4, and testosterone per reproductive cycle phase was statistically significant. The distribution of 17β-estradiol plasma concentration in the specimens classified as spawning capable was higher than the specimens classified in other reproductive phases. The spawning capable phase was significantly and positively associated with the summer and autumn seasons. Thus, was possible to propose that the spawning season begins in late spring and until the middle of autumn in the Callao coast area. The recorded superficial temperature and daylight hours per day performed in the specimen’s collection area, allowed us to propose a thermo-photoperiod program for the management of broodstock. This should include the first cycle with temperatures between 12.5 - 13.5°C with an 11/13 light/darkness photoperiod, then the temperature should be increased to 16 - 17°C, with a 13/11 light/darkness photoperiod as a second cycle. Although the results of this study are limited to a specific area of the Callao coast, establishing the reproductive cycle and the spawning dynamics of A. scapularis females associated with environmental parameters, provides basic knowledge to improve the aquaculture of this species.
The difference between the effectiveness of body-weight-supported treadmill training combined with functional electrical stimulation and sole body-weight-supported treadmill training for improving gait parameters in stroke patients: A systematic review and meta-analysis
Authors: Wang Jiaqi , Zhao Liangyu , Gao Yan , Liu Chenchen , Dong Xiaosheng , He Xiqian 
Published: November 2022

BackgroundBody-weight-supported treadmill training (BWSTT) combined with functional electrical stimulation (FES) is considered an effective intervention method to improve gait parameters in stroke patients. In this article, we compared the effect of BWSTT combined with FES and BWSTT only on gait parameters in stroke patients.MethodsTwo researchers searched for literature published before January 5, 2021, in seven Chinese and English databases including PubMed, Web of Science, Cochrane Library, Ovid, CNKI, Wanfang Data, and VIP. Meta-analysis was then performed on various data collected, namely, 10 Meters Walking Test (10MWT), gait speed, Fugl-Meyer Assessment (FMA), Berg Balance Scale (BBS), Modified Barthel Index (MBI), Comprehensive Spasticity Scale (CSS), Functional Ambulation Category (FAC), and Ankle Range of Motion (AROM).ResultsA total of 14 studies were included in the meta-analysis, in which 945 stroke patients participated. In these 14 studies, the participants were randomly divided into a test group and a control group. The test group received BWSTT combined with FES, while the control group received BWSTT only. Meta-analysis showed that when compared to BWSTT, BWSTT combined with FES had a better effect on FAC, AROM, 10MWT, CSS, MBI, FMA, gait speed, and BBS of stroke patients. However, the effect of BWSTT combined with FES on BBS was not significant in the medium exercise group when compared to that of BWSTT. Also, the effect of BWSTT combined with FES on gait speed was not significant in the large exercise group when compared to that of BWSTT only.ConclusionBWSTT combined with FES is more effective than BWSTT only for improving gait parameters in stroke patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/#recordDetails, CRD42022299636.
Hemodynamic indicators of the formation of tandem intracranial aneurysm based on a vascular restoration algorithm
Authors: Yao Yunchu , Tong Xin , Mei Yuqian , Yu Fan , Shan Yi , Liu Aihua , Chen Duanduan 
Published: November 2022

BackgroundHemodynamic factors are believed to be closely related to IA growth. However, the underlying pathophysiological mechanism that induces the growth sequence in tandem intracranial aneurysms (IAs) remains unclear.Methods and resultsThis study involved five patients with tandem IAs. Aneurysm models were reconstructed based on image datasets. A novel vascular restoration algorithm was proposed to generate the hypothetical geometry of the healthy parent vessel before each IA formation in the concatenated structure. Detailed hemodynamic patterns and morphological features were revealed under various growth sequences of tandem IAs to investigate the flow-driven mechanism of IA growth. Potential hemodynamic indicators of IA formation were proposed.ResultsThe patient cases were divided into two groups based on the size difference of tandem IAs. In the group with a similar size of tandem IAs, the position of the vortex core was associated with the site of the secondary aneurysm, while in the group with a significant size difference of the IAs, the position with the maximum curvature of the parent vessel plays a significant role in aneurysm formation.ConclusionsThis study preliminarily revealed key hemodynamic and morphological indicators that determine the formation of tandem IAs. The proposed vascular restoration algorithm that provided the pre-aneurysm vasculature might be useful in investigating the flow-driven mechanism of IA growth, thus contributing to the risk evaluation of secondary aneurysm formation.
Clusters of conditions among US service members diagnosed with mild TBI from 2017 through 2019
Authors: Hai Tajrina , Agimi Yll , Stout Katharine 
Published: November 2022

BackgroundMany US Military Service Members (SMs) newly diagnosed with mild Traumatic Brain Injury (mTBI) may exhibit a range of symptoms and comorbidities, making for a complex patient profile that challenges clinicians and healthcare administrators. This study used clustering techniques to determine if conditions co-occurred as clusters among those newly injured with mTBI and up to one year post-injury.MethodsWe measured the co-occurrence of 41 conditions among SMs diagnosed with mTBI within the acute phase, one or three months post-mTBI diagnosis, and chronic phase, one year post-mTBI diagnosis. Conditions were identified from the literature, clinical subject matter experts, and mTBI care guidelines. The presence of conditions were based on medical encounters recorded within the military health care data system. Through a two-step approach, we identified clusters. Principal component analysis (PCA) determined the optimal number of clusters, and hierarchical cluster analyses (HCA) identified the composition of clusters. Further, we explored how the composition of these clusters changed over time.ResultsOf the 42,018 SMs with mTBI, 23,478 (55.9%) had at least one condition of interest one-month post-injury, 26,831 (63.9%) three months post-injury, and 29,860 (71.1%) one year post injury. Across these three periods, six clusters were identified. One cluster included vision, cognitive, ear, and sleep disorders that occurred one month, three months, and one year post-injury. Another subgroup included psychological conditions such as anxiety, depression, PTSD, and other emotional symptoms that co-occurred in the acute and chronic phases post-injury. Nausea and vomiting symptoms clustered with cervicogenic symptoms one month post-injury, but later shifted to other clusters. Vestibular disorders clustered with sleep disorders and headache disorders one-month post-injury and included numbness and neuropathic pain one year post-injury. Substance abuse symptoms, alcohol disorders, and suicidal attempt clustered one year post-injury in a fifth cluster. Speech disorders co-occurred with headache disorders one month and one year post-injury to form a sixth cluster.ConclusionPCA and HCA identified six distinct subgroups among newly diagnosed mTBI patients during the acute and chronic phases post-injury. These subgroups may help clinicians better understand the complex profile of SMs newly diagnosed with mTBI.
Robotic-assisted versus standard laparoscopic radical cystectomy in bladder cancer: A systematic review and meta-analysis
Authors: Long Junhao , Wang Li , Dong Ni , Bai Xiaoli , Chen Siyu , Sun Shujun , Liang Huageng , Lin Yun 
Published: November 2022

BackgroundThis study aimed to evaluate the efficacy and safety of robotic-assisted radical cystectomy (RARC) versus laparoscopic radical cystectomy (LRC) in the treatment of bladder cancer.MethodsTwo researchers independently searched PubMed, Embase, Cochrane, and CBM using the index words to identify the qualified studies which included randomized controlled trials (RCTs) and non-randomized controlled trials (prospective and retrospective studies), and the investigators scanned references of these articles to prevent missing articles. Differences in clinical outcomes between the two procedures were analyzed by calculating odds risk (OR) and mean difference (MD) with an associated 95% confidence interval (CI).ResultsSixteen comparative studies were included in the meta-analysis with 1467 patients in the RARC group and 897 patients in the LRC group. The results indicated that RARC could significantly decrease blood loss (P = 0.01; MD: -82.56, 95% CI: -145.04 to -20.08), and complications 90 days or more after surgery, regardless of whether patients were Grade ≤ II (P = 0.0008; OR: 0.63, 95% CI: 0.48 to 0.82) or Grade ≥ III (P = 0.006; OR: 0.59, 95% CI: 0.40 to 0.86), as well as overall complications (P: 0.01; OR = 0.52; 95% CI: 0.32 to 0.85). However, there was no statistical difference between the two groups at total operative time, intraoperative complications, transfusion rate, short-term recovery, hospital stay, complications within 30 days of surgery, and bladder cancer-related mortality.ConclusionsThe meta-analysis demonstrates that RARC is a safe and effective treatment for bladder cancer, like LRC, and patients with RARC benefit from less blood loss and fewer long-term complications related to surgery, and should be considered a viable alternative to LRC. There still need high-quality, larger sample, multi-centric, long-term follow-up RCTs to confirm our conclusion.