bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing the Quality of Human-Robot Cooperation Through the Optimization of Human Well-Being and Productivity
Authors: Messeri Costanza 
Published: November 2022

AbstractIn human-robot interaction frameworks maximizing the team efficiency is crucial. However, it is also essential to mitigate the physical and cognitive workload experienced by the shop-floor worker during the collaborative task. In this chapter we first investigate the impact of the robot interaction role (whether being leader or follower during cooperation) on both the human physiological stress and production rate. Based on that, a game-theoretic approach is proposed to model the trade-off between the maximization of the human performance and the minimization of the human cognitive stress. Then, we describe a closed-loop robot control strategy that, based on the proposed game-theoretic model, enables the robot to simultaneously minimize the human cognitive stress and maximize his/her performance during cooperation, by adjusting its role. Eventually, a real-time task allocation strategy is proposed to both ensure the minimization of the human physical fatigue and the effectiveness of the production process. This method relies on a new sophisticated musculoskeletal model of the human upper-body. All these methodologies have been experimentally tested in realistic human-robot collaborative scenarios involving several volunteers and the ABB IRB 14000 dual-arm “YuMi" collaborative robot.
Stability of the microcanonical ensemble in Euclidean Quantum Gravity
Authors: Marolf Donald , Santos Jorge E. 
Published: November 2022

Abstract
This work resolves a longstanding tension between the physically-expected stability of the microcanonical ensemble for gravitating systems and the fact that the known negative mode of the asymptotically flat Schwarzschild black hole decays too rapidly at infinity to affect the ADM energy boundary term at infinity. The key to our study is that we fix an appropriate off-shell notion of energy, which we obtain by constructing the microcanonical partition function as an integral transform of the canonical partition function. After applying the rule-of-thumb for Wick rotations from our recent companion paper to deal with the conformal mode problem of Euclidean gravity, we find a positive definite action for linear perturbations about any Euclidean Schwarzchild (-AdS) black hole. Most of our work is done in a cavity with reflecting boundary conditions, but the cavity wall can be removed by taking an appropriate limit.
The effect of internal control quality on real and accrual-based earnings management: evidence from France
Authors: Boulhaga Mounia , Bouri Abdelfettah , Elbardan Hany 
Published: November 2022

AbstractThis paper examines the effect of internal control (IC) quality, measured by IC weakness disclosures, on the quality of financial statements’ information, measured by real and accrual-based earnings management. The sample consists of 686 firm-year observations of French non-financial companies listed in the SBF 120 index during the period between 2012 and 2018. Using ordinary least squares (OLS) and generalized method of moments (GMM) regression, our empirical results indicate that IC weakness disclosures are positively and significantly related to real activities manipulation and negatively associated with discretionary accruals. This provides empirical evidence that a good system of IC reduces accrual-based earnings management activities and improves the reliability of financial statements; however, it cannot control real earnings management (REM). The research findings are of practical interest not only to financial analysts, auditors, and investors—guiding them to pay attention to REM activities in case of disclosures of IC weaknesses—but also to regulators, who may consider additional disclosure requirements when reporting material IC weaknesses and designing policies that could help in reducing REM practices.
Oscillation and Concentration in Sequences of PDE Constrained Measures
Authors: Kristensen Jan , Raiță Bogdan 
Published: November 2022

AbstractWe show that for constant rank partial differential operators $$\mathscr {A}$$
A
whose wave cones are spanning, generalized Young measures generated by bounded sequences of $$\mathscr {A}$$
A
-free measures can be characterized by duality with $$\mathscr {A}$$
A
-quasiconvex integrands of linear growth. This includes a characterization of the concentration effects in such sequences that allows us to conclude that, in sharp contrast to the oscillation effects, the concentration always has $$\mathscr {A}$$
A
-free structure.
The influence of tDCS on perceived bouncing/streaming
Authors: Friehs Maximilian A. , Stegemann Marlena J. , Merz Simon , Geißler Christoph , Meyerhoff Hauke S. , Frings Christian 
Published: November 2022

AbstractProcessing ambiguous situations is a constant challenge in everyday life and sensory input from different modalities needs to be integrated to form a coherent mental representation on the environment. The bouncing/streaming illusion can be studied to provide insights into the ambiguous perception and processing of multi-modal environments. In short, the likelihood of reporting bouncing rather than streaming impressions increases when a sound coincides with the moment of overlap between two moving disks. Neuroimaging studies revealed that the right posterior parietal cortex is crucial in cross-modal integration and is active during the bouncing/streaming illusion. Consequently, in the present study, we used transcranial direct current stimulation to stimulate this brain area. In the active stimulation conditions, a 9 cm2 electrode was positioned over the P4-EEG position and the 35 cm2 reference positioned over the left upper arm. The stimulation lasted 15 min. Each participant did the bouncing/streaming task three times: before, during and after anodal or sham stimulation. In a sample of N = 60 healthy, young adults, we found no influence of anodal tDCS. Bayesian analysis showed strong evidence against tDCS effects. There are two possible explanations for the finding that anodal tDCS over perceptual areas did not modulate multimodal integration. First, upregulation of multimodal integration is not possible using tDCS over the PPC as the integration process already functions at maximum capacity. Second, prefrontal decision-making areas may have overruled any modulated input from the PPC as it may not have matched their decision-making criterion and compensated for the modulation.
Fire behaviour of a Carbon/Nomex honeycomb sandwich composite used in aircraft interiors as ceiling panel
Authors: Papadogianni V. , Romeos A. , Perrakis K. , Panidis T. 
Published: November 2022

AbstractFire behaviour of a carbon/Nomex honeycomb composite, used as ceiling panel in aircraft cabins, has been investigated experimentally. The thermal decomposition that was examined in a thermogravimetric analyser (TGA), under inert atmosphere, at several heating rates (5,10 and 20 °C/min), revealed a complex degradation process with overlapping stages. Cone Calorimeter tests at different incident heat fluxes, ranging from 20 to 70 kW/m2 have also been performed. The material exhibited good fire performance with relatively low amount of heat release and long ignition times. Ignition did not occur at 20 and 30 kW/m2. Combustion of the material at 40 kW/m2 proceeded in one stage, while at higher heat fluxes two stages were observed. The burning mechanisms and structural changes during thermal decomposition at different heat fluxes were also examined. The long tail after flameout in heat release curves and the significant increase in CO production and mass loss were analysed with respect to smouldering combustion of the material core. Measurements of the surface temperature prior to ignition were in agreement with the degradation processes observed in the TGA, and were also employed for the determination of ignition temperature (Tig = 593 °C). A modified iterative method, based on the correlation of the ignition data with the imposed heat flux, was adopted for the determination of the ignition parameters, including critical heat flux and temperature for ignition, providing results in agreement with experimental observations.
Generation of NK cells with chimeric-switch receptors to overcome PD1-mediated inhibition in cancer immunotherapy
Authors: Susek Katharina H. , Schwietzer Ysabel A. , Karvouni Maria , Gilljam Mari , Keszei Marton , Hussain Alamdar , Lund Johan , Kashif Muhammad , Lundqvist Andreas , Ljunggren Hans-Gustaf , Nahi Hareth , Wagner Arnika K. , Alici Evren 
Published: November 2022

AbstractMultiple myeloma (MM) is an incurable hematological cancer, in which immune checkpoint inhibition (ICI) with monoclonal antibodies (mAbs) has failed due to uncontrollable immune responses in combination therapies and lack of efficacy in monotherapies. Although NK cell-specific checkpoint targets such as NKG2A and KIRs are currently being evaluated in clinical trials, the clinical impact of NK cells on the PD1 cascade is less well understood compared to T cells. Furthermore, while NK cells have effector activity within the TME, under continuous ligand exposure, NK cell dysfunctionality may occur due to interaction of PD1 and its ligand PD-L1. Due to above-mentioned factors, we designed novel NK cell specific PD1-based chimeric switch receptors (PD1-CSR) by employing signaling domains of DAP10, DAP12 and CD3ζ to revert NK cell inhibition and retarget ICI. PD1-CSR modified NK cells showed increased degranulation, cytokine secretion and cytotoxicity upon recognition of PD-L1+ target cells. Additionally, PD1-CSR+ NK cells infiltrated and killed tumor spheroids. While primary NK cells (pNK), expressing native PD1, showed decreased degranulation and cytokine production against PD-L1+ target cells by twofold, PD1-CSR+ pNK cells demonstrated increased activity upon PD-L1+ target cell recognition and enhanced antibody-dependent cellular cytotoxicity. PD1-CSR+ pNK cells from patients with MM increased degranulation and cytokine expression against autologous CD138+PD-L1+ malignant plasma cells. Taken together, the present results demonstrate that PD1-CSR+ NK cells enhance and sustain potent anti-tumor activity in a PD-L1+ microenvironment and thus represent a promising strategy to advance adoptive NK cell-based immunotherapies toward PD-L1+ cancers.
Shared genetic risk across different presentations of gene test–negative idiopathic nephrotic syndrome
Authors: Downie Mallory L. , Gupta Sanjana , Chan Melanie M. Y. , Sadeghi-Alavijeh Omid , Cao Jingjing , Parekh Rulan S. , Diz Carmen Bugarin , Bierzynska Agnieszka , Levine Adam P. , Pepper Ruth J. , Stanescu Horia , Saleem Moin A. , Kleta Robert , Bockenhauer Detlef , Koziell Ania B. , Gale Daniel P. 
Published: November 2022

Abstract
Background
Idiop
athic nephrotic syndrome (INS) is classified in children according to response to initial corticosteroid therapy into steroid-sensitive (SSNS) and steroid-resistant nephrotic syndrome (SRNS), and in adults according to histology into minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). However, there is well-recognised phenotypic overlap between these entities. Genome-wide association studies (GWAS) have shown a strong association between SSNS and variation at HLA, suggesting an underlying immunological basis. We sought to determine whether a risk score generated from genetic variants associated with SSNS could be used to gain insight into the pathophysiology of INS presenting in other ways.

Methods
We developed an SSNS genetic risk score (SSNS-GRS) from the five variants independently associated with childhood SSNS in a previous European GWAS. We quantified SSNS-GRS in independent cohorts of European individuals with childhood SSNS, non-monogenic SRNS, MCD, and FSGS, and contrasted them with SSNS-GRS quantified in individuals with monogenic SRNS, membranous nephropathy (a different immune-mediated disease-causing nephrotic syndrome), and healthy controls.

Results
The SSNS-GRS was significantly elevated in cohorts with SSNS, non-monogenic SRNS, MCD, and FSGS compared to healthy participants and those with membranous nephropathy. The SSNS-GRS in all cohorts with non-monogenic INS were also significantly elevated compared to those with monogenic SRNS.

Conclusions
The shared genetic risk factors among patients with different presentations of INS strongly suggests a shared autoimmune pathogenesis when monogenic causes are excluded. Use of the SSNS-GRS, in addition to testing for monogenic causes, may help to classify patients presenting with INS.

Graphical abstract
On the Dynamic Fragmentation of Rock-Like Spheres: Insights into Fragment Distribution and Energy Partition
Authors: Guccione Davide Ettore , Giacomini Anna , Thoeni Klaus , Fityus Stephen , Buzzi Olivier 
Published: November 2022

AbstractFragmentation of blocks upon impact is commonly observed during rockfall events. Nevertheless, fragmentation is not properly taken into account in the design of protection structures because it is still poorly understood. This paper presents an extensive and rigorous experimental campaign that aims at bringing insights into the understanding of the complex phenomenon of rock fragmentation upon impact. A total of 114 drop tests were conducted with four diameters (50, 75, 100, and 200 mm) of rock-like spheres (made of mortar) of three different strengths (34, 23 and 13 MPa), falling on a horizontal concrete slab, with the objective to gather high-quality fragmentation data. The analysis focuses on the fragment size distribution, the energy dissipation mechanisms at impact and the distribution of energy amongst fragments after impact. The results show that the fragment size distributions obtained in this campaign are not linear on a logarithmic scale. The total normalised amount of energy loss during the impact increases with impact velocity, and consequently the total kinetic energy after impact decreases. It was also found that energy loss to create the fracture surfaces is a constant fraction of the kinetic energy before impact. The trajectories of fragments are related to the impact velocity. At low impact velocity, the fragments tend to bounce but, as the impact velocity increases, they tend to be ejected sideways. Although testing mortar spheres in normal impact is a simplification, the series of tests presented in this work has brought some valuable understanding into the fragmentation phenomenon of rockfalls.
Intelligent analysis of the quality of education through teaching practices on virtual campuses
Authors: Alvarez-Blanco Lucia , Castro-Lopez Adrian , Cervero Antonio 
Published: November 2022

AbstractICTs have been increasingly involved in teaching–learning processes due to the potential offered by the tools as well as to the set of demands derived from the political and health situations of the social environment. In this sense, the introduction of virtual campuses as complex systems that centralize the entire technological component that complements traditional teaching processes has meant a change of paradigm with repercussions at the teaching and pedagogical level. In this context, the purpose of this study aims to analyze students’ perception of the use of virtual campus and how to enhance the quality of the educational process using intelligent systems. For this purpose, 318 students that use virtual campus have been surveyed. The results show that there are three variables that predominantly influence the quality of teaching–learning processes using virtual campuses: frequent contact with teachers through the platform, the digital competence of the student, and the adaptation of training content to the students’ prior knowledge. This information can be useful, as it allows them to establish guidelines to guide the practices of their teaching teams in technological environments, guaranteeing the suitability of the teaching–learning process and improving the evaluation processes and the assessment of their own educational work.
Osteoporosis treatment in Austria—assessment of FRAX-based intervention thresholds for high and very high fracture risk
Authors: Dimai Hans P. , Johansson Helena , Harvey Nicholas C. , Lorentzon Mattias , Liu Enwu , Vandenput Liesbeth , Fahrleitner-Pammer Astrid , Pietschmann Peter , Muschitz Christian , McCloskey Eugene V. , Kanis John A. 
Published: November 2022

Abstract

Summary

The adoption of the management pathway proposed by the National Osteoporosis Guideline Group (NOGG), UK applied using the Austrian FRAX® tool in a referral population of Austrian women categorises 22–29% of women age 40 years or more eligible for treatment of whom 28–34% are classified at very high risk.

Purpose
The aim of this study is to provide a reference document for the further development of existing guidelines for the management of osteoporosis in Austria, considering FRAX-based intervention thresholds for high and very high fracture risk.

Methods
The model development was based on two Austrian hospital referral cohorts. Baseline information was collected to compute the 10-year probability (using the Austrian FRAX model) of a major osteoporotic fracture (MOF) and hip fracture both with and without the inclusion of femoral neck bone mineral density (BMD). Assessment thresholds for BMD testing were defined, as well as intervention thresholds. In addition, thresholds that characterise men and women at high and very high fracture risk were established. The management pathway followed that currently recommended by the UK National Osteoporosis Guideline Group (NOGG).

Results
The two cohorts comprised a total of 1306 women and men with a mean age of 66.7 years. Slightly more than 50% were eligible for treatment by virtue of a prior fragility fracture. In those women without a prior fracture, 22% (n = 120) were eligible for treatment based on MOF probabilities. Of these, 28% (n = 33) were found to be at very high risk. When both MOF and hip fracture probabilities were used to characterise risk, 164 women without a prior fracture were eligible for treatment (29%). Of these, 34% (n = 56) were found to be at very high risk. Fewer men without prior fracture were eligible for treatment compared with women.

Conclusion
The management pathway as currently outlined is expected to reduce inequalities in patient management. The characterisation of very high risk may aid in the identification of patients suitable for treatment with osteoanabolic agents.
Experimental study of the low salinity water injection process in the presence of scale inhibitor and various nanoparticles
Authors: Khormali Azizollah , Koochi Mojtaba Rezaei , Varfolomeev Mikhail A. , Ahmadi Soroush 
Published: November 2022

AbstractIn this work, the process of low salinity water injection (LSWI) into reservoirs at various salt concentrations was simulated in order to study the change in the oil recovery factor during oil production. The simulation results of the recovery factor were compared with the experimental data. The results demonstrated that the simulation data were in good agreement with the experimental results. In addition, the formation damage (rock permeability reduction) in carbonate core samples was evaluated through coreflood experiments during LSWI in the range of salt concentration and temperature of 1500–4000 ppm and 25–100 °C, respectively. In the worst scenario of LSWI, the rock permeability has reached about 83% of the initial value. Our previous correlation was used to predict the formation damage in LSWI. In this case, the R-squared value between predicted and experimental data of rock permeability ratios was more than 0.97. Furthermore, the recovery factor during LSWI was analyzed with and without the use of DTPMP scale inhibitor (diethylenetriamine penta (methylene phosphonic acid)), and various nanoparticles (TiO2, SiO2, Al2O3). The results of the coreflood experiments showed that the use of scale inhibitor provides an increase in the recovery factor by more than 8%. In addition, the highest recovery factor was observed in the presence of SiO2 nanoparticles at 0.05 wt.%. The oil displacement during LSWI in the porous media with SiO2 particles was better than TiO2 and Al2O3. The recovery factor in the presence of SiO2, TiO2, and Al2O3 with DTPMP was 72.2, 62.4, and 59.8%, respectively. Among the studied nanoparticles, the lowest values of the oil viscosity and interfacial tension (IFT) between oil and water were observed when using SiO2. Moreover, the contact angle was increased by increasing the brine concentration. The contact angle with the use of SiO2, TiO2, and Al2O3 at 0.05 wt.% was reduced by 11.2, 10.6, and 9.9%, respectively.
High-temperature catalytic pyrolysis of radiata pine for production of high-value products
Authors: Iminabo Misel , Yip Alex C. K. , Iminabo John T. , Pang Shusheng 
Published: November 2022

Abstract In this study, high-temperature catalytic pyrolysis of radiata pine was investigated for the production of high-value gas products. Pyrolysis experiments were conducted in a fluidized bed reactor at temperatures of 600 to 850 °C. The effect of temperature and the addition of titanomagnetite as the catalyst was evaluated based on product distribution, gas composition, gas properties, and tar composition. The results show that with titanomagnetite, the maximum gas yield of 72.9% was achieved at 850 °C, which is higher than that of the non-catalytic pyrolysis at the same temperature. The main gas species in the gas product from the catalytic pyrolysis at 850 °C include hydrogen (12.8 vol%), carbon monoxide (37.6 vol%), carbon dioxide (35.8 vol%), methane (5.8 vol%), and ethylene (5.8 vol%). Also, with titanomagnetite, the maximum lower heating value of 23.0 MJ/Nm3 for the product gas was achieved at 800 °C, and the maximum value for hydrogen to carbon monoxide (0.34) was found at 850 °C. Titanomagnetite promoted the formation of oxygenated hydrocarbons such as acids, esters, and phenols in tar, but at 850 °C, the tars from both catalytic and non-catalytic pyrolysis were rich in naphthalenes (more than 40%). H2-reduced titanomagnetite performed equally as the unreduced titanomagnetite with respect to gas yield, but the hydrogen and ethylene contents in the gas from the pyrolysis at 850 °C were 21.5 and 21.8 vol%, respectively. At this temperature, the lower heating value of the gas from the catalytic pyrolysis with the H2-reduced titanomagnetite was 17.4 MJ/Nm3, and the hydrogen to carbon monoxide ratio was 2.6.
Abstracts najaarsvergadering NVU, 4 november 2022
Authors:   Bohn Stafleu van Loghum
Published: November 2022

SamenvattingHet preoperatief voorspellen van de kans op pelviene lymfekliermetastasen is cruciaal om patiënten te selecteren die in aanmerking komen voor een uitgebreide pelviene lymfeklierdissectie (ePLND), ten tijde van de radicale prostatectomie (RARP).