bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internet-based psychotherapy in children with obsessive-compulsive disorder (OCD): protocol of a randomized controlled trial
Authors: Conzelmann Annette , Hollmann Karsten , Haigis Anna , Lautenbacher Heinrich , Bizu Verena , App Rehan , Nickola Matthias , Wewetzer Gunilla , Wewetzer Christoph , Ivarsson Tord , Skokauskas Norbert , Wolters Lidewij H. , Skarphedinsson Gudmundur , Weidle Bernhard , de Haan Else , Torp Nor Christian , Compton Scott N. , Calvo Rosa , Lera-Miguel Sara , Alt Annika , Hohnecker Carolin Sarah , Allgaier Katharina , Renner Tobias J. 
Published: February 2022

Abstract
Background
Obsessive-compulsive disorder (OCD) in children can lead to a huge burden on the concerned patients and their family members. While successful state-of-the art cognitive behavioral interventions exist, there is still a lack of available experts for treatment at home, where most symptoms manifest. Internet-based cognitive behavioral therapy (iCBT) could overcome these restrictions; however, studies about iCBT in children with OCD are rare and mostly target computerized self-help resources and only email contact with the therapist. Therefore, we intended to build up and to evaluate an iCBT approach for children with OCD, replacing successful elements of traditional in-office face-to-face CBT, with face-to-face teleconferences, online materials, and apps.

Methods
With the help of a pilot feasibility study, we developed the iCBT consisting of 14 teleconference sessions with the child and parents. The sessions are supported by an app assessing daily and weekly symptoms and treatment course completed by children and parents. Additionally, we obtain heart rate and activity scores from the child via wristbands during several days and exposure sessions. Using a waiting list randomized control trial design, we aim to treat and analyze 20 children with OCD immediately after a diagnostic session whereas the control group of another set of 20 OCD patients will be treated after waiting period of 16 weeks. We will recruit 30 patients in each group to take account for potential dropouts. Outcomes for the treatment group are evaluated before randomization (baseline, t0), 16 weeks (end of treatment, t1), 32 weeks (follow-up 1, t2), and 48 weeks after randomization (follow-up 2, t3). For the waiting list group, outcomes are measured before the first randomization (baseline), at 16 weeks (waiting list period), 32 weeks (end of treatment), 48 weeks after the first randomization (follow-up I), and 64 weeks after the first randomization (follow-up II).

Discussion
Based on our experience of feasibility during the pilot study, we were able to develop the iCBT approach and the current study will investigate treatment effectiveness. Building up an iCBT approach, resembling traditional in-office face-to-face therapy, may ensure the achievement of well-known therapy effect factors, the acceptance in both patients and clinicians, and the wide distribution within the health system.

Trial registration
ClinicalTrials.govNCT05037344. Registered May 2019, last release August 13th, 2021.
3D reconstruction from structured-light profilometry with dual-path hybrid network
Authors: Wang Lei , Lu Dunqiang , Qiu Ruowen , Tao Jiaqing 
Published: February 2022

AbstractWith the rapid development of high-speed image sensors and optical imaging technology, these have effectively promoted the improvement of non-contact 3D shape measurement. Among them, striped structured-light technology has been widely used because of its high measurement accuracy. Compared with classical methods such as Fourier transform profilometry, many deep neural networks are utilized to restore 3D shape from single-shot structured light. In actual engineering deployments, the number of learnable parameters of convolution neural network (CNN) is huge, especially for high-resolution structured-light patterns. To this end, we proposed a dual-path hybrid network based on UNet, which eliminates the deepest convolution layers to reduce the number of learnable parameters, and a swin transformer path is additionally built on the decoder to improve the global perception of this network. The experimental results show that the learnable parameters of the model are reduced by 60% compared with the UNet, and the measurement accuracy is not degraded at the same time. The proposed dual-path hybrid network provides an effective solution for structured-light 3D reconstruction and its practice in engineering.
Don’t change who we are but give us a chance: confronting the potential of community health worker certification for workforce recognition and exclusion
Authors: Kissinger Ashley , Cordova Shakira , Keller Ann , Mauldon Jane , Copan Lori , Rood Claire Snell 
Published: February 2022

Abstract
Background
For community health workers (CHWs) and promotores de salud (CHWs who primarily serve Latinx communities and are grounded in a social, rather than a clinical model of care), the process of certification highlights the tension between developing a certified workforce with formal requirements (i.e., certified CHWs) and valuing CHWs, without formal requirements, based on their roles, knowledge, and being part of the communities where they live and work (i.e., non-certified CHWs). California serves as an ideal case study to examine how these two paths can coexist. California’s CHW workforce represents distinct ideologies of care (e.g., clinical CHWs, community-based CHWs, and promotores de salud) and California stakeholders have debated certification for nearly twenty years but have not implemented such processes.

Methods
We employed purposive sampling to interview 108 stakeholders (i.e., 66 CHWs, 11 program managers, and 31 system-level participants) to understand their perspectives on the opportunities and risks that certification may raise for CHWs and the communities they serve. We conducted focus groups with CHWs, interviews with program managers and system-level participants, and observations of public forums that discussed CHW workforce issues. We used a thematic analysis approach to identify, analyze, and report themes.

Results
Some CHW participants supported inclusive certification training opportunities while others feared that certification might erode their identity and undermine their work in communities. Some program managers and system-level participants acknowledged the opportunities of certification but also expressed concerns that certification may distance CHWs from their communities. Program managers and system-level participants also highlighted that certification may not address all challenges related to integrating CHWs into health care systems. CHWs, program managers, and system-level participants agreed that CHWs should be involved in certification discussions and decision making.

Conclusions
To address participant concerns, our findings recommend California stakeholders build a voluntary certification process structured with multiple pathways to overcome entry barriers of traditional certification processes, maintain CHW identity, and protect diversity within the workforce. Positioning CHWs as decision makers will be critical when designing state certification processes.
Trust and willingness towards COVID-19 vaccine uptake: a mixed-method study in Ghana, 2021
Authors: Amo-Adjei Joshua , Nurzhynska Anastasiia , Essuman Ruth , Lohiniva Anna-Leena 
Published: February 2022

Abstract
Background
On the account of limited doses of COVID-19 available to the country, the Government of Ghana created a priority list of persons to target for its vaccination agenda. In this paper, we look at trust and how it informs willingness to take the COVID-19 vaccine among persons targeted for the first phase of COVID-19 vaccination program in Ghana.

Methods
A sequential mixed-method investigation was conducted among the priority population - persons 60 years and above, frontline government functionaries, health workers, persons with underlying health conditions and, religious leaders and teachers. We sampled 415 respondents from the target population for a survey and 15 religious and traditional leaders from three cities; Accra, Cape Coast and Tamale for follow-up in-depth interviews based on the results of the survey data. Quantitative data is presented with descriptive proportions and multinomial logistic regression and thematic approach is applied to the interview data.

Results
Trust and willingness to take the vaccine are high in this priority population. Trust in the effectiveness and safety of the vaccine, rather than socioeconomic characteristics of respondents better predicted acceptance. From interview narratives, mistrust in political actors - both local and foreign, believe in superior protection of God and seeming misunderstanding of vaccine development processes countermand acceptance. On the other hand, the professional influence of people in one’s social networks, and past triumphs of vaccination programmes against concerning childhood diseases embed trust and acceptance.

Conclusions
Attention ought to be given to trust enhancing triggers while strategic communication approaches are used to remove triggers of mistrust.
Altered gut metabolites and microbiota interactions are implicated in colorectal carcinogenesis and can be non-invasive diagnostic biomarkers
Authors: Coker Olabisi Oluwabukola , Liu Changan , Wu William Ka Kei , Wong Sunny Hei , Jia Wei , Sung Joseph J. Y. , Yu Jun 
Published: February 2022

AbstractBackgroundGut microbiota contributes to colorectal cancer (CRC) pathogenesis through microbes and their metabolites. The importance of microbiota-associated metabolites in colorectal carcinogenesis highlights the need to investigate the gut metabolome along the adenoma-carcinoma sequence to determine their mechanistic implications in the pathogenesis of CRC. To date, how and which microbes and metabolites interactively promote early events of CRC development are still largely unclear. We aim to determine gut microbiota-associated metabolites and their linkage to colorectal carcinogenesis.ResultsWe performed metabolomics and metagenomics profiling on fecal samples from 386 subjects including 118 CRC patients, 140 colorectal adenomas (CRA) patients and 128 healthy subjects as normal controls (NC). We identified differences in the gut metabolite profiles among NC, CRA and CRC groups by partial least squares-discriminant and principal component analyses. Among the altered metabolites, norvaline and myristic acid showed increasing trends from NC, through CRA, to CRC. CRC-associated metabolites were enriched in branched-chain amino acids, aromatic amino acids and aminoacyl-tRNA biosynthesis pathways. Moreover, metabolites marker signature (twenty metabolites) classified CRC from NC subjects with an area under the curve (AUC) of 0.80, and CRC from CRA with an AUC of 0.79. Integrative analyses of metabolomics and metagenomics profiles demonstrated that the relationships among CRC-associated metabolites and bacteria were altered across CRC stages; certain associations exhibited increasing or decreasing strengths while some were reversed from negative to positive or vice versa. Combinations of gut bacteria with the metabolite markers improved their diagnostic performances; CRC vs NC, AUC: 0.94; CRC vs CRA, AUC 0.92; and CRA vs NC, AUC: 0.86, indicating a potential for early diagnosis of colorectal neoplasia.ConclusionsThis study underscores potential early-driver metabolites in stages of colorectal tumorigenesis. The Integrated metabolite and microbiome analysis demonstrates that gut metabolites and their association with gut microbiota are perturbed along colorectal carcinogenesis. Fecal metabolites can be utilized, in addition to bacteria, for non-invasive diagnosis of colorectal neoplasia.
Improving the surveillance and response system to achieve and maintain malaria elimination: a retrospective analysis in Jiangsu Province, China
Authors: Cao Yuanyuan , Lu Guangyu , Cotter Chris , Wang Weiming , Yang Mengmeng , Liu Yaobao , Liang Cheng , Zhou Huayun , Lu Yan , Yan Jun , Zhu Guoding , Cao Jun 
Published: February 2022

Abstract
Background
Following initiation of China’s National Malaria Elimination Action Plan (NMEAP) in 2010, the ‘1-3-7’ approach was developed and rolled out in China to facilitate the malaria elimination programme and accelerate malaria elimination. This study aims to summarize and condense these experiences through a retrospective analysis in Jiangsu Province, which could be adapted and applied in other malaria elimination settings worldwide.

Methods
A retrospective analysis of imported malaria cases into China identified through an improved surveillance and response system in Jiangsu Province was carried out for the period of 2001–2020. To improve the malaria surveillance and response system, Centers for Diseases Control and Prevention from the prefectures and counties in Jiangsu province conducted population-level health education to improve healthcare seeking behavior, strengthened capacity of health facilities to improve performance of malaria diagnosis and treatment, and raised the capacity of public health providers to improve implementation of the ‘1-3-7’ approach. Categorical variables were carried out by Chi square tests with Fisher’s exact correction.

Results
From 2001 to 2020, a total of 9,879 malaria cases were reported in Jiangsu Province. Since 2012, no indigenous malaria cases have been reported in Jiangsu Province. However, in recent years, there has been a substantial increase of imported falciparum malaria cases. Between 2012 and 2020, an estimated 61.57 million individuals have benefited from population-level health education in Jiangsu Province. For healthcare-seeking services among the 2,423 imported malaria cases, 687 (28.4%) and 1,104 (45.6%) cases visited hospitals on the first day and the second day from symptom onset, respectively. A total of 1,502 (61.9%) cases were diagnosed on the first day at medical facilities. Jiangsu Province achieved 100%, 99.4% and 98.3% completion rate in terms of case detection and notification (within one day), case investigation (within three days) and foci response and disposition (within seven days), respectively. The improved surveillance and response system in Jiangsu Province plays an important role in preventing the re-introduction of malaria and maintaining the malaria-free status.

Conclusions
Jiangsu Province has maintained its malaria-free status since 2012. The continuous improvement of a surveillance and response system plays an important role in the early detection and rapid response of potential malaria-related outbreaks in Jiangsu, China, and has important lessons for other malaria eliminating settings. Remaining vigilant in the detection of imported malaria cases and maintaining an active surveillance and response system is critical to sustain the success of malaria elimination.

Graphic Abstract
No sound is more distracting than the one you're trying not to hear: delayed costs of mental control of task-irrelevant neutral and emotional sounds
Authors: Kolbeinsson Örn , Asutay Erkin , Enström Manja , Sand Jonas , Hesser Hugo 
Published: February 2022

Abstract
Background
Suppressing intrusive thoughts can result in a post-suppression rebound effect where the same thoughts become hyperaccessible. The current study aimed to investigate if similar so-called rebound effects could be observed when people attempted to mentally suppress awareness of nonsensical auditory stimuli. Based on previous research on thought suppression and mental control in other domains, we hypothesized that attempting to suppress awareness of a task-irrelevant sound while under cognitive load would impact evaluations of the sound on affective dimensions and loudness, and result in increased general vigilance, as evidenced by faster responding on subsequent tasks.

Methods
We performed two experiments where participants in a suppression condition were initially instructed to mentally suppress awareness of a sound while performing a mentally challenging task. Participants in a control condition performed the same task without receiving any instructions regarding the sound. In Experiment 1, the sound was affectively neutral, while in Experiment 2 participants were presented with an inherently aversive (tinnitus-like) sound. After this initial phase, participants performed tasks measuring vigilance and attention, and were also asked to give subjective ratings of the sounds on a number of affective dimensions and loudness.

Results
In Experiment 1, participants in the suppression condition showed faster response times on both a visual search task and an auditory spatial cueing task, as compared to participants in the control condition. Contrary to our predictions, participants in the suppression condition did not rate the distractor sound as louder than participants in the control condition, and there were no differences on affective dimensions. In Experiment 2, results revealed that participants in the suppression condition made more errors on a visual search task, specifically on trials where the previously suppressed sound was presented. In contrast to results from Experiment 1, participants in the suppression condition also rated the targeted sound as louder.

Conclusions
The findings provide preliminary support for a post-suppression rebound effect in the auditory domain and further suggest that this effect may be moderated by the emotional properties of the auditory stimulus.
Assessing the suitability of new film laminates for sustainable insect eradication by modified atmosphere in museums
Authors: Elkhial Manar M. , El Hadidi Nesrin M. N. 
Published: February 2022

Abstract
The increasing demand for applying modified inert atmosphere systems for insect eradication in museums has led to the desire for lower-cost consumable materials, particularly laminated plastic films. An ultra-low oxygen-permeable laminate is required for creating successful systems of modified inert atmosphere to keep the oxygen concentration lower than 0.3%. A range of ultra-high barrier laminates is commercially available but at a high cost, which could affect the sustainability of applying these systems in museums of limited budgets. The wide use of local laminates for food preservation makes them a perfect target for testing and improvement as alternatives. However, a laboratorial test method for evaluating their oxygen permeability is required to assess their suitability for insect eradication using modified atmospheres. Therefore, the present work investigates the potential of using two laminates (one local and one imported) to create a successful modified atmosphere system. A laboratory easy-to-use test method was used to assess the oxygen permeability of each laminate and calculate its oxygen transmission rate. The test method is a sealed static chamber separated in the middle by a known area of the laminate to be tested. The test relies on monitoring the change of oxygen concentration overtime on either side of the laminate membrane within the sealed system to assess its oxygen transmission rate. The specifications and design of the test chamber are adopted from the ASTM Designation: E2945 − 14. Results indicated that the new method is useful for an unlimited number of tests of an unlimited number of laminates. The conducted tests proved that the local laminate normally used for food packaging showed good results in terms of its oxygen transmission rate.
Neighborhood risk factors for sports and recreational injuries: a systematic review of studies applying multilevel modeling techniques
Authors: Ogunmayowa Oluwatosin , Baker Charlotte 
Published: February 2022

Abstract
Background
Sports and recreational activities are the most commonly reported cause of injury-related emergency department (ED) visits among children and young adults in developed countries, yet studies about the effect of neighborhood environment on sports and recreational injuries (SRI) are very limited. The aim of this study was to systematically review studies that apply multilevel modeling approach in examining the relationships between SRI and neighborhood-level risk factors.

Data sources
A systematic search of peer reviewed English language articles was conducted in four electronic databases including PubMed (1992–2020), CINAHL (2000–2020), Sports Medicine and Education Index (1996–2020), and Web of Science (1991–2020).

Study selection
Selected studies were observational or experimental studies of people of all ages across the world that assessed neighborhood risk factors for SRI (or all injuries including SRI) using multilevel regression analysis.

Data synthesis
Nine studies—five cross-sectional, two prospective cohort, and two incidence studies—were selected out of a potential 1510. Six studies used secondary data and three used primary data. Only three studies examined SRI as the main or one of the main outcomes. These studies showed that neighborhood-level factors, such as higher socioeconomic context, lower street connectivity, and living or attending schools in urban communities, were associated with increased risk of SRI. Most studies did not provide a justification for the use of multilevel regression and the multilevel analytical procedure employed and quantities reported varied. The Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies (National Institutes of Health) was used to assess the quality or risk of bias of each study. Four quality assessment criteria out of 15 were met by all nine studies. The quality assessment ratings of the reviewed studies were not correlated with the quality of information reported for the multilevel models.

Conclusion
Findings from this review provide evidence that neighborhood-level factors, in addition to individual-level factors, should be taken into consideration when developing public health policies for injury prevention. Considering the limited numbers of studies that were identified by this systematic review, more multilevel studies are needed to strengthen this evidence in order to better inform SRI prevention policy decisions.
Refractory otitis media with effusion due to eustachian tube sialolipoma inform consistent with eustachian tube inflammatory polyp: rare case presentation and literature review
Authors: Al Zaabi Khalid , Badr-El-Dine Mohamed M. K. 
Published: February 2022

Abstract
Background
Unilateral otitis media with effusion in adult patient is considered alarming finding needing a detailed examination of the nasopharynx. The lesions in this area ranged from benign to more destructive malignant pathologies. Lipoma as a cause of obstruction is an extremely rare entity. We are reporting a case of eustachian tube lipoma presented with refractory otitis media with effusion. This is an extremely rare location of such entity and to the best of our knowledge, this is the third case reported in the world literature of eustachian tube lipoma after 2 cases published in 2011 and 2016 respectively. However, this is the first case reported in the literature of eustachian tube sialolipoma.

Case presentation
We are reporting a 27-year-old male who presented to our outpatient department with a complain of unilateral ear block, hearing loss, and intermittent tinnitus. Clinical evaluation revealed unilateral otitis media with effusion that was confirmed by pure tone audiogram and tympanometry. Computed tomography and magnetic resonance imaging were obtained showed a lesion originating in the eustachian tube area protruding in the nasopharynx. Surgical removal was successful with complete recovery.

Conclusions
Unilateral otitis media with effusion necessitate nasal endoscopic examination to rule-out lesions at the nasopharynx. This is the first case of sialolipoma in eustachian tube in the literature. Endoscopic removal is usually successful with uneventful short recovery period.