bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening safe pesticide application rates in crop fields for protecting consumer health: A backward model for interim recommended rates
Authors: Li Zijian 
Published: March 2022

Abstract
To reduce human health risks and comply with regulatory standards, it is necessary to provide safe application rates of pesticides in crop fields. In this study, a screening-level model is proposed to improve the regulation of pesticide application rates based on the dynamiCrop platform, which can serve as a complementary approach to field trials for regulatory agencies. The screening-level model can conveniently simulate safe application rates of pesticides based on consumer health risks and maximum residue levels (MRLs). Using 2,4-D as an example, the simulation results agreed with the data of field trials under Good Agricultural Practices and demonstrated that current manufacturers' recommended application rates can effectively comply with MRLs and protect human health. In addition, we simulated the default safe application rates of 449 pesticides in five common crops using the default values of the acceptable daily intake (ADI; 0.01 mg kg−1 day−1) and MRL (0.01 mg kg−1). The results demonstrated that aerial-fruit crops (e.g., tomatoes and apples) had much lower default safe application rates of pesticides than tuber crops due to the different pesticide uptake mechanisms of plants. In addition, the MRL-based default safe application rates were significantly lower than the ADI-based default rates, indicating that the default MRL of 0.01 mg kg−1 adopted by current regulatory agencies is very conservative regarding population health risks. Although other factors, such as the variability of residue levels in crops, occupational exposure (farmers and operators), and multiple pesticide application patterns, need to be considered in future studies, our screening-level model could be used as a complementary tool in field trials to assist regulatory agencies in regulating pesticide application rates in crop fields. Integr Environ Assess Manag 2023;19:126–138. © 2022 SETAC.
Fucoxanthin prevents cell growth and induces apoptosis in endometrial cancer HEC‐1A cells by the inhibition of the PI3K/Akt/mTOR pathway
Authors: Qu Jinfeng , Sun Yaping , Yang Lukai , Niu Xiaoxiao , Li Lanyu 
Published: March 2022

AbstractEndometrial cancer is the major type of gynecological cancer and ranks as the sixth most common cancer in women. Endometrial cancer usually is diagnosed in an advanced stage, complicating the treatments in many cases. The present research was focused on unveiling the in vitro anticancer role of fucoxanthin against the endometrial cancer HEC‐1A cells by inhibiting the phosphatidylinositol‐3‐kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling axis. The cytotoxicity of fucoxanthin against the endometrial cancer HEC‐1A cells was studied using the MTT test. The level of reactive oxygen species (ROS) production, mitochondrial membrane potential (MMP) status, and apoptotic cell death in the 7.5 and 10 µM administered HEC‐1A cells were assayed using fluorescent staining techniques. The messenger RNA expression was analyzed using RT‐PCR for PI3K/Akt/mTOR signaling molecules, proapoptotic (Bax and caspase‐3) antiapoptotic (cyclin D1 and Bcl‐2) genes, and inflammatory markers like tumour necrosis factor α (TNFα), nuclear factor kappa B (NF‐κB), Cox‐2, and interleukin (IL)‐6. The cell viability assay proved that fucoxanthin effectively prevented HEC‐1A cell viability, where the IC50 was 7.5 µM. Fucoxanthin at 7.5  and 10 µM remarkably improved ROS production and apoptosis and decreased the MMP in HEC‐1A cells. The fucoxanthin effectively inhibited the PI3K/Akt/mTOR cascade along with the expression of TNF‐α, NF‐κB, Cox‐2, and IL‐6 and antiapoptotic genes cyclin D1 and Bcl‐2 in the HEC‐1A cells. Fucoxanthin treatment also enhanced the Bax and caspase‐3 expressions in the HEC‐1A cells. Our results from this work unveiled that fucoxanthin triggered growth inhibition and apoptosis in endometrial cancer HEC‐1A cells. Besides, fucoxanthin inhibited the PI3K/Akt/mTOR cascade and improved apoptotic marker expressions in the HEC‐1A cells.
A hazard identification digital simulation game developed based on the extended authentic learning framework
Authors: Safiena Sufiana , Goh Yang Miang 
Published: March 2022

AbstractBackgroundPrevious research has shown that the inability to identify hazards is the leading cause of workplace accidents and fatalities. The lack of competency in hazard identification implies a crucial need to improve the teaching and learning approaches in construction safety training and education.Purpose/HypothesisThis study developed the extended authentic learning framework (EALF) to design a digital simulation game (DSG) called SafeSim Hazards and tested students' perception of its effectiveness in workplace safety and health (WSH) education.Design/MethodsUndergraduates majoring in Project and Facilities Management (PFM) used SafeSim Hazards to learn about hazard identification. A questionnaire was used to collect student perceptions of the game and its effectiveness. In addition, random forest analyses were used to identify critical factors that affect the perceived achievement of learning outcomes.ResultsGuidance is the most influential authentic learning factor, and game interaction is an essential design factor in influencing the perceived achievement of learning outcomes. Notably, participants reported high acceptance toward SafeSim Hazards with an average rating of 3.36 out of 4.ConclusionsThe key contributions of this study are threefold: (1) An EALF is developed to facilitate the development of construction hazard identification DSG. (2) It is demonstrated that the DSG developed based on EALF is well received by students with minimum construction experience. (3) It is recommended that future construction hazard identification DSG for inexperienced trainees should emphasize guidance and game interactions.
Reproducibility and postacquisition correction methods for quantitative magnetic resonance imaging of the anterior cruciate ligament (ACL)
Authors: Flannery Sean W. , Walsh Edward G. , Sanborn Ryan M. , Chrostek Cynthia A. , Costa Meggin Q. , Kaushal Shankar G. , Murray Martha M. , Fleming Braden C. , Kiapour Ata M. 
Published: March 2022

AbstractQuantitative magnetic resonance imaging has been used to evaluate the structural integrity of knee joint structures. However, variations in acquisition parameters between scanners pose significant challenges. Understanding the effect of small differences in acquisition parameters for quantitative sequences is vital to the validity of cross‐institutional studies, and for the harmonization of large, heterogeneous datasets to train machine learning models. The study objective was to assess the reproducibility of T2* relaxometry and the constructive interference in steady‐state sequence (CISS) across scanners, with minimal hardware‐necessitated changes to acquisition parameters. It was hypothesized that there would be no significant differences between scanners in anterior cruciate ligament T2* relaxation times and CISS signal intensities (SI). Secondarily, it was hypothesized that differences could be corrected by rescaling the SI distribution to harmonize between scanners. Seven volunteers were scanned on 3T Prisma and Tim Trio scanners (Siemens). Three correction methods were evaluated for T2*: inverse echo time scaling, z‐scoring, and Nyúl histogram matching. For CISS, scans were normalized to cortical bone, scaled by the background noise ratio, and log‐transformed. Before correction, significant mean differences of 6.0 ± 3.2 ms (71.8%; p = 0.02) and 0.49 ± 0.15 units (40.7%; p = 0.02) for T2* and CISS across scanners were observed, respectively. After rescaling, T2* differences decreased to 2.6 ± 2.7 ms (23.9%; p = 0.03), 1.3 ± 2.5 ms (10.9%; p = 0.13), and 1.27 ± 3.0 ms (19.6%; p = 0.40) for inverse echo time, z‐scoring, and Nyúl, respectively, while CISS decreased to 0.01 ± 0.11 units (4.0%; p = 0.87). These findings suggest that small acquisition parameter differences may lead to large changes in T2* and SI values that must be reconciled to compare data across magnets.
A Narrow Bandgap, Isocyanide‐Based Coordination Polymer Framework for Micro‐Supercapacitors with AC Line‐Filtering Performance
Authors: Yang Hang , Zhao Yazhen , Chen Zhenying , Huang Senhe , Lu Chenbao , Ke Changchun , Zhai Guangqun , Zhu Jinhui , Zhuang Xiaodong 
Published: March 2022

AbstractThe rapid expansion of wearable electronic devices boosts the development of energy storage minicomponents. Among them, the on‐chip micro‐supercapacitors (MSCs) have aroused widespread interest due to their distinctive characteristics, e.g., long cycle life, high power density, etc. Herein, an on‐chip MSC device is fabricated by using an isocyanide‐based coordination polymer framework as electrode material. Due to the narrow bandgap, flexibility, and compatibility of the coordination polymer, such MSC device with LiCl/PVA electrolyte delivers large capacitances (up to 0.98 mF cm−2 and 20.56 F cm−3 at a scan rate of 0.1 V s−1) and a short time constant (0.026 ms), which are comparable to the state‐of‐the‐art MSCs with polymer film electrodes. Moreover, this MSC device exhibits good AC line‐filtering ability (−70.8° at 120 Hz). This work introduces an implementable interfacial method to obtain coordination polymer frameworks for constructing miniaturized energy storage devices.
Multiple Resonance Dendrimers Containing Boron, Oxygen, Nitrogen‐Doped Polycyclic Aromatic Emitters for Narrowband Blue‐Emitting Solution‐Processed OLEDs
Authors: Liu Jiapeng , Chen Liang , Wang Xingdong , Yang Qingqing , Zhao Lei , Tong Cuiyan , Wang Shumeng , Shao Shiyang , Wang Lixiang 
Published: March 2022

AbstractIn contrast to small‐molecule multiple resonance emitters processed via vacuum evaporation technology, the design of multiple resonance dendrimers is presented by introducing the first‐ and second‐generation carbazole dendrons in the periphery of boron, oxygen, nitrogen‐doped polycyclic aromatic skeleton, for efficient narrowband blue electroluminescence by a solution process. The multiple resonance dendrimers not only keep the narrowband emission of the polycyclic aromatic skeleton, but also can suppress their intermolecular aggregation by steric carbazole dendrons, overcoming the unwanted spectral broadening in the solid state. The resultant first‐generation carbazole dendrimer exhibits narrowband blue emission with promising photoluminescent quantum efficiency of 94% and delayed fluorescence with a lifetime of 139.1 µs in the solid‐state film. Solution‐processed organic light‐emitting diodes based on the dendrimers reveal electroluminescence at 488 nm with full‐width at half maximum of 39 nm, the maximum luminous efficiency of 29.2 cd A−1, and maximum external quantum efficiency of 13.4%.
CircFOXM1 acts as a ceRNA to upregulate SMAD2 and promote the progression of nasopharyngeal carcinoma
Authors: Pei Shuai , Ma Chengxian , Chen Jie , Hu Xinyu , Du Mingyu , Xu Tian , Zhan Mengna , Xue Ke , Zhang Yufeng , Yin Li , He Xia 
Published: March 2022

AbstractBackgroundIn recent years, the development of high‐throughput sequencing technology has promoted the rapid development of circRNA‐related research. Studies have found that circRNA plays a key role in a variety of tumors, but few people study the role of circRNA in nasopharyngeal carcinoma. Under comprehensive treatments, the 5‐year survival rate can reach about 70%, but some patients still have distant metastases or recurrences after treatment. Therefore, it is very important to study the molecular mechanisms of the proliferation and invasion of nasopharyngeal carcinoma.MethodsQRT‐PCR was applied to detect the relative expression level of circFOXM1 in NPC and nasopharyngeal epithelial cell lines. We knocked down circFOXM1 and studied the influence of circFOXM1 on NPC cells. Nuclear and cytoplasmic RNA isolation experiments, fluorescence in situ hybridization (FISH), bioinformatics analysis, the dual‐luciferase reporter experiment, Western Blot, and other experiments were conducted to verify the relationships among circFOXM1, miR‐136‐5p, and SMAD2. We collected clinical NPC samples to prove the effect of circFOXM1 on the prognosis and treatment of NPC.ResultsIn this study, we found that circFOXM1 is highly expressed in nasopharyngeal carcinoma tissue cells compared with adjacent normal tissues and is related to the staging of nasopharyngeal carcinoma. High expression of circFOXM1 indicates a poor prognosis for nasopharyngeal carcinoma. Knockdown of CircFOXM1 inhibited the proliferation and invasion of nasopharyngeal carcinoma cells.ConclusionCircFOXM1 promotes the malignant proliferation of nasopharyngeal carcinoma cells by regulating the miR‐136‐5p‐SMAD2 axis.
Deep phenotyping and whole‐exome sequencing improved the diagnostic yield for nuclear pedigrees with neurodevelopmental disorders
Authors: Wang Qingqing , Tang Xia , Yang Ke , Huo Xiaodong , Zhang Hui , Ding Keyue , Liao Shixiu 
Published: March 2022

AbstractBackgroundNeurodevelopmental disorders, a group of early‐onset neurological disorders with significant clinical and genetic heterogeneity, remain a diagnostic challenge for clinical genetic evaluation. Therefore, we assessed the diagnostic yield by combining standard phenotypes and whole‐exome sequencing in families with these disorders that were “not yet diagnosed” by the traditional testing methods.MethodsUsing a standardized vocabulary of phenotypic abnormalities from human phenotype ontology (HPO), we performed deep phenotyping for 45 “not yet diagnosed” pedigrees to characterize multiple clinical features extracted from Chinese electronic medical records (EMRs). By matching HPO terms with known human diseases and phenotypes from model organisms, together with whole‐exome sequencing data, we prioritized candidate mutations/genes. We made probable genetic diagnoses for the families.ResultsWe obtained a diagnostic yield of 29% (13 out of 45) with probably genetic diagnosis, of which compound heterozygosity and de novo mutations accounted for 77% (10/13) of the diagnosis. Of note, these pedigrees are accompanied by a more significant number of non‐neurological features.ConclusionsDeep phenotyping and whole‐exome sequencing improve the etiological evaluation for neurodevelopmental disorders in the clinical setting.
Effect of Reproductive Status on Some Biochemical Parameters in American Shad
Authors: Gao Xiao-Qiang , Liu Zhi-Feng , Huang Bin , Wang Yao-Hui , Zhao Kui-Feng , Chen Hai-Bin , Xing Rui , Hong Lei 
Published: March 2022

Abstract
The pattern of some blood biochemical parameters of adult American Shad Alosa sapidissima was investigated during their reproductive cycle. A total of 288 subadult broodfish were captured between October 2015 and September 2016, of which 10 broodfish for each developmental stage were selected based on similar length and weight to evaluate the overall health status of the fish. The results showed that the serum levels of total protein, albumin, globulin, glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase, low-density lipoprotein, high-density lipoprotein, plasma glucose, triglycerides (TG), total cholesterol (TC), Ca2+, and P of the American Shad broodstock (females and males) significantly increased as their gonads developed, reaching the highest levels at stages IV and V, after which the above-mentioned parameters substantially decreased at stage VI. The TC and TG levels in females significantly increased from stage II to stage V and then the levels began to decrease after spawning (stage VI), but there was no significant difference in TC and TG levels in males. With the development of the gonads, the plasma glucose, superoxide dismutase, catalase, and lysozyme levels in both male and female broodfish showed different degrees of decline; in stages V (spawning period) and VI (postnatal period), these parameters significantly decreased. The results of this study indicate that physiological parameters (e.g., blood glucose level, blood lipid level, and antioxidant capacity) of American Shad broodfish, especially females, show varying degrees of reduction during reproduction, which suggests that nutritional imbalance significantly reduces immunity during the postnatal period.
Efficacy of capacitive resistive monopolar radiofrequency in the physiotherapeutic treatment of chronic pelvic pain syndrome: A randomized controlled trial
Authors: Carralero‐Martínez Andrea , Muñoz Pérez Miguel A. , Kauffmann Stèphanie , Blanco‐Ratto Laia , Ramírez‐García Inés 
Published: March 2022

AbstractAimTo evaluate the efficacy of adjuvant, capacitive resistive monopolar radiofrequency (CRMRF, INDIBA) treatment at 448 kHz together with physiotherapeutic techniques compared to a sham treatment with the same techniques, for pain reduction and quality of life (QoL) improvements in patients with chronic pelvic pain syndrome (CPPS).MethodsA triple‐blind, randomized controlled trial (RCT) including patients with CPPS randomly allocated (1:1) to a CRMRF‐activated group (intervention) or a CRMRF‐deactivated one (control). Both groups received physiotherapeutic techniques and pain education weekly for 10 consecutive weeks. Data from a visual analogical scale and the SF‐12 questionnaire were collected at trial commencement and repeated at the 5th and 10th sessions. Pain intensity was considered the main outcome. For the comparisons between variables, the χ2 and Student's t test were used. Superiority was analyzed by estimating the mean change (95% confidence interval). Analysis was performed for the per‐protocol and the intention‐to‐treat populations. The statistical significance level was set at p < 0.05.ResultsEighty‐one patients were included (67.9% women) with a mean age of 43.6 years (SD 12.9). CRMRF lessened pain scores by more than 2 points and improved QoL by 5 points. There were no relevant side effects and overall adherence to the treatment was 86.4%.ConclusionsThis is the first RCT that evaluates the efficacy of CRMRF (INDIBA) compared to a sham treatment, and demonstrates its superiority in decreasing pain and improving QoL. Such results may lead to greater prescribing of CRMRF when treating CPPS patients.
A morphological and mechanical analysis of composites from modified bagasse fibers and recycled polyvinyl chloride
Authors: Youssef Ahmad M. , Abd El‐Aziz Mahmoud E. , Abouzeid Ragab E. 
Published: March 2022

AbstractBagasse raw materials were filled with recycled polyvinyl chloride composites via compounding and compression molding. In this research, unmodified, soda treated, and oxidized bagasse fibers were combined in different concentrations (5%, 10%, 15%, and 20%) with pure PVC/recycled PVC (30:70 wt). The composites surfaces were examined as well as their mechanical properties, crystallization behavior, and biodegradation properties. It was found that uniformity in the distribution of the bagasse fibers in the microstructure of the polymer composites was a major factor affecting the mechanical properties. The oxidized bagasse fiber loaded composite matrix gives the best mechanical and biodegradation properties compared with the untreated and soda treated bagasse fibers. In addition to increasing modulus and tensile strength, fiber loading also reduced hardness. X‐ray diffraction investigation illustrated that introducing fiber to a p‐ PVC/r‐PVC matrix did not affect characteristic peak positions. Packaging applications can be further developed with these composite materials.
Property enhancement approaches of fused filament fabrication technology: A review
Authors: Pazhamannil Ribin Varghese , V. N. Jishnu Namboodiri , P. Govindan , Edacherian Abhilash 
Published: March 2022

AbstractThe shift from rapid prototyping to rapid manufacturing using 3D printing is prominent after the development of volumetric 3D printing, multi‐material printing, and functional materials development. Fused filament fabrication (FFF) is a fast‐growing additive manufacturing technology with widespread end‐user applications. The key constraints to its growth are the lower surface and mechanical properties compared to conventional manufacturing paradigms. The goal of this review is to look at the numerous pre‐processing and post‐processing parameters for the property enhancement of FFF. Pre‐processing methods included optimization of process parameters (infill percentage, pattern, layer height, nozzle and platform temperature, raster angle and width, build orientation, and air gap) and adaptive slicing techniques. Mechanical (hot air jetting, barrel finishing, sand blasting, laser polishing, etc.), chemical (vapor smoothing, dipping, plating, and painting), and thermal (thermal annealing and normalizing) post‐processing techniques were successful in improving the mechanical strength and surface finish of fused filament fabricated parts. This paper outlines the various methodologies a FFF user could incorporate for enhancing the final finished product's properties. The potential future prospects for the development of the 3D printing sector are also examined.
Salt leaching as a green method for the production of polyethylene foams for thermal energy storage applications
Authors: Sorze Alessandro , Valentini Francesco , Dorigato Andrea , Pegoretti Alessandro 
Published: March 2022

AbstractMaterials able to store thermal energy can be a useful strategy to reduce energy consumption of buildings and to decrease greenhouse gases emissions. In this work, for the first time, the technique of salt leaching has been used to produce novel polyethylene foams containing different amounts of a microencapsulated phase‐change material (PCM) with a melting point of 24°C, to be potentially applied in building insulation. The microstructural, thermal, and mechanical properties of produced foams have been comprehensively investigated. The prepared foams were characterized by high values of open porosity (about 60%) and by density values around 0.4 g/cm3. Infrared thermography analysis demonstrated that the time required from the samples to reach a set temperature, thanks to the presence of PCM, was up to two times higher with respect to the reference foam. Therefore, these materials could store/release an interesting amount of thermal energy. Shore‐A measurements evidenced that the addition of PCM generally led to a softening of the foams. Tensile mechanical tests confirmed the softening effect provided by the addition of the microcapsules, with a decrease of the stiffness and of the strength of the material. Interestingly, strain‐at‐break values were considerably increased upon PCM introduction.