bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of 2-(4-N,N-Dimethylaminophenyl)-5-methyl-1-phenethyl-1H-benzimidazole targeting HIV-1 CA capsid protein and inhibiting HIV-1 replication in cellulo
Authors: Alvarez Guzmán , van Pul Lisa , Robert Xavier , Artía Zoraima , van Nuenen Ad C. , Long Mathieu , Sierra Natalia , Porcal Williams , Kootstra Neeltje A. , Guillon Christophe 
Published: June 2022

AbstractThe capsid (CA) subunit of the HIV-1 Gag polyprotein is involved in several steps of the viral cycle, from the assembly of new viral particles to the protection of the viral genome until it enters into the nucleus of newly infected cells. As such, it represents an interesting therapeutic target to tackle HIV infection. In this study, we screened hundreds of compounds with a low cost of synthesis for their ability to interfere with Gag assembly in vitro. Representatives of the most promising families of compounds were then tested for their ability to inhibit HIV-1 replication in cellulo. From these molecules, a hit compound from the benzimidazole family with high metabolic stability and low toxicity, 2-(4-N,N-dimethylaminophenyl)-5-methyl-1-phenethyl-1H-benzimidazole (696), appeared to block HIV-1 replication with an IC50 of 3 µM. Quantitative PCR experiments demonstrated that 696 does not block HIV-1 infection before the end of reverse transcription, and molecular docking confirmed that 696 is likely to bind at the interface between two monomers of CA and interfere with capsid oligomerization. Altogether, 696 represents a promising lead molecule for the development of a new series of HIV-1 inhibitors.
Tonga volcanic eruption and tsunami, January 2022: globally the most significant opportunity to observe an explosive and tsunamigenic submarine eruption since AD 1883 Krakatau
Authors: Terry James P. , Goff James , Winspear Nigel , Bongolan Vena Pearl , Fisher Scott 
Published: June 2022

AbstractJanuary 2022 witnessed the violent eruption of Hunga Tonga–Hunga Haʻapai submarine volcano in the South Pacific. With a volcanic explosivity index possibly equivalent to VEI 5, this represents the largest seaborne eruption for nearly one and a half centuries since Indonesia’s cataclysmic explosion of Krakatau in AD 1883. The Tongan eruption remarkably produced ocean-wide tsunamis, never documented before in the Pacific instrumental record. Volcanically generated tsunamis have been referred to as a ‘blind spot’ in our understanding of tsunami hazards, particularly in the Pacific Ocean. This event therefore presents a unique opportunity for investigating the multiple processes contributing to volcanic tsunamigenesis. It is argued that, although challenges exist, integrating theoretical, observational, field and modelling techniques offers the best approach to improving volcanic tsunami hazard assessment across Oceania.
Competition between Circularly Polarized Light and Molecular Chirality in the Assembly of Main-chain Liquid Crystalline Polymers
Authors: Sakaino Hirotoshi , Meskers Stefan C J , Meijer E W , Vantomme Ghislaine 
Published: June 2022

Abstract
Polymeric systems responding to chiral information are actively pursued for applications in optoelectronics and photonics. Here we report on the diastereomeric relationship between chiral liquid crystal polymers and circularly polarized light (CPL). We synthesize a chiral copolymer incorporating photoisomerizable diazobenzene moieties as well as isosorbide-based monomers. The circular dichroism of the film can be inverted by irradiation with CPL indicating that the influence of the chiral subunits on the helicity of the cholesteric arrangement can be overruled by the action of CPL. By following the out-of-equilibrium photo-switching process over time, we demonstrate that the formation of helical ordering in the chiral liquid crystal phases is much faster by CPL irradiation than by heat.
Increased rate of pseudarthrosis in the anterior intersegmental gap after mandibular reconstruction with fibula free flaps: a volumetric analysis
Authors: Steffen Claudius , Fischer Heilwig , Sauerbrey Marius , Heintzelmann Thelma , Voss Jan Oliver , Koerdt Steffen , Checa Sara , Kreutzer Kilian , Heiland Max , Rendenbach Carsten 
Published: June 2022

Objectives: Pseudarthrosis after mandibular reconstruction leads to chronic overload of the osteosynthesis and impedes dental rehabilitation. This study evaluates the impact of gap site on osseous union in mandible reconstruction using a new volumetric analysis method with repeated cone-beam computed tomography (CBCT). Methods: The degree of bone regeneration was evaluated in 16 patients after mandible reconstruction with a fibula free flap and patient-specific reconstruction plates. Percentual bone volume and width changes in intersegmental gaps were retrospectively analyzed using a baseline CBCT in comparison to a follow-up CBCT. Patients’ characteristics, plate-related complications, and gap sites (anterior/posterior) were analyzed. Detailed assessments of both gap sites (buccal/lingual/superior/inferior) were additionally performed. Results: Intersegmental gap width (p = 0.002) and site (p < 0.001) significantly influence bone volume change over two consecutive CBCTs. An initial larger gap width resulted in a lower bone volume change. In addition, anterior gaps showed significantly less bone volume changes. Initial gap width was larger at posterior segmental gaps (2.97 vs 1.65 mm, p = 0.017). Conclusions: A methodology framework has been developed that allows to quantify pseuarthrosis in reconstructed mandibles using CBCT imaging. The study identifies the anterior segmental gap as a further risk factor for pseudarthrosis in reconstructions with CAD/CAM reconstruction plates. Future research should evaluate whether this outcome is related to the biomechanics induced at this site.
Comparative study of the effect of U100 laser and pneumatic ballistic combined with percutaneous transhepatic cholangioscopic lithotomy in the treatment of intra-and extrahepatic bile duct stones and its effect on liver function
Authors: Yin Zhongliang , Shen Bin 
Published: June 2022

Objectives: To compare the efficiency of U100 laser and pneumatic ballistics combined with percutaneous transhepatic cholangioscopic lithotripsy (PTCSL) in the treatment of intra-and extrahepatic bile duct stones and their effects on liver function.
Methods: Medical records of 97 patients with intra-and extrahepatic bile duct stones treated in our hospital from May 2020 to May 2021 were selected for retrospective analysis. Of them, forty-three patients received pneumatic ballistic lithotripsy combined with PTCSL (Group-I), and 54 patients received U100 laser lithotripsy combined with PTCSL (Group-II). The therapeutic effects of the treatment in two groups and its effect on liver function were compared and analyzed.
Results: There was no significant difference in the operation time and intraoperative bleeding (P>0.05) between the two groups. The postoperative pain duration and hospital stay of patients treated with U100 laser lithotripsy combined with PTCSL (Group-II) were shorter than those treated with pneumatic ballistic lithotripsy combined with PTCSL (Group-I), P<0.05. The biliary bleeding rate of patients in Group-II was lower (3.70%) than those in Group-I (16.27%, P<0.05), and the stone residue rate of patients in Group-II was also lower (1.85%) than those in Group-I (11.63%, P<0.05). The levels of total bilirubin (TBIL), alanine aminotransferase (ALT) and albumin (ALB) in Group-II patients were higher than in patients in Group-I.(P<0.05).
Conclusion: Compared with pneumatic ballistics, U100 laser lithotripsy combined with PTCSL in the treatment of intra and extrahepatic bile duct stones has the advantages of less postoperative pain, shorter hospital stay, less biliary bleeding and stone residue, and less damage to liver function.
doi: https://doi.org/10.12669/pjms.38.6.5903
How to cite this:Yin Z, Shen B. Comparative study of the effect of U100 laser and pneumatic ballistic combined with percutaneous transhepatic cholangioscopic lithotomy in the treatment of intra-and extrahepatic bile duct stones and its effect on liver function. Pak J Med Sci. 2022;38(6):---------. doi: https://doi.org/10.12669/pjms.38.6.5903
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Incidence, predictors and prognostic impact of acute kidney injury in patients with COVID-19
Authors: Saeed Sahrai , Guerrot Dominique 
Published: June 2022

doi: https://doi.org/10.12669/pjms.38.6.6475
How to cite this:Saeed S, Guerrot D. Incidence, predictors and prognostic impact of acute kidney injury in patients with COVID-19. Pak J Med Sci. 2022;38(6):---------. doi: https://doi.org/10.12669/pjms.38.6.6475
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DEVEA: an interactive shiny application for Differential Expression analysis, data Visualization and Enrichment Analysis of transcriptomics data
Authors: Riquelme-Perez Miriam , Perez-Sanz Fernando , Deleuze Jean-François , Escartin Carole , Bonnet Eric , Brohard Solène 
Published: June 2022

We are at a time of considerable growth in the use and development of transcriptomics studies and subsequent in silico analysis. RNA sequencing is one of the most widely used approaches, now integrated in many studies. The processing of these data may typically require a noteworthy number of steps, statistical knowledge, and coding skills which is not accessible to all scientists. Despite the undeniable development of software applications over the years to address this concern, it is still possible to improve. Here we present DEVEA, an R shiny application tool developed to perform differential expression analysis, data visualization and enrichment pathway analysis mainly from transcriptomics data, but also from simpler gene lists with or without statistical values. Its intuitive and easy-to-manipulate interface facilitates gene expression exploration through numerous interactive figures and tables, statistical comparisons of expression profile levels between groups and further meta-analysis such as enrichment analysis, without bioinformatics expertise. DEVEA performs a thorough analysis from multiple and flexible input data representing distinct analysis stages. From them, it produces dynamic graphs and tables, to explore the expression levels and statistical differential expression analysis results. Moreover, it generates a comprehensive pathway analysis to extend biological insights. Finally, a complete and customizable HTML report can be extracted for further result exploration outside the application. DEVEA is accessible at https://shiny.imib.es/devea/ and the source code is available on our GitHub repository https://github.com/MiriamRiquelmeP/DEVEA.
Pain management in the first stage of labour using sensory stimulation
Authors: Mujiyani Surya Andina , Latifah Lutfatul 
Published: June 2022

Background Severe pain during the first stage of labour can harm both the mother and fetus. Previous studies have shown that severe pain in childbirth can cause discomfort, stress, risk of depressive disorders, decreased intestinal motility and prolonged labour for the mother. For the fetus, it can cause hypoxia, metabolic acidosis, cognitive and emotional disorders and even death. Therefore, better management of labour pain during the first stage is needed. Aim This study aimed to assess the effect of sensory stimulation to reduce pain in the first stage of labour. Methods Garuda portal, the Perpustakaan Nasional Republik Indonesia e-resource, the Cochrane Central Register of Controlled Trials and Pubmed were used to search for literature. The inclusion criteria were original randomised controlled trials published in English, in 2014–2020, with a minimum sample size of 30 where the study outcome was rated on a pain scale. Results Ten randomised controlled trials were included. The primary interventions using sensory stimulation to reduce pain during the first stage of labour were aromatherapy, music therapy, breathing control, focusing, and virtual reality. Conclusions Sensory stimulation by aromatherapy, music therapy, breathing control, focusing and virtual reality are effective in reducing pain in the first stage of labour.
Understanding autoimmune diseases in primary care
Authors: Perry Margaret 
Published: June 2022

Autoimmune diseases are complex. Margaret Perry describes the most common diseases and explains how they can impact patients Autoimmune diseases vary widely in their presentation, symptoms, as well as their impact on the health, wellbeing and quality of life of those affected. This article aims to help practice nurses understand how these conditions arise, and also give a brief insight into their treatment and management with the aim of improving practice nurses' confidence when advising and supporting patients affected by any of the diseases discussed.
Novel elemental grading system for radiographic lumbar spondylosis in a population based-cohort study of a Japanese mountain village
Authors: Yamada Junichi , Akeda Koji , Takegami Norihiko , Fujiwara Tatsuhiko , Nishimura Akinobu , Sudo Akihiro 
Published: June 2022

Purpose
Lumbar radiography is a primary screening tool for lumbar spondylosis (LS). Kellgren-Lawrence (KL) classification is widely used to evaluate LS; however, it cannot individually evaluate each radiographic feature. The purpose of this study was to 1) evaluate radiographic LS using a novel elemental grading system and 2) investigate the relationship between the grades of radiographic LS and low back pain (LBP) in a population-based cohort study.

Methods
A total of 260 (75 men, 185 women; mean age, 71.5 ± 8.7 years) participants were included in this study. Participants were divided into two groups according to the presence of LBP (LBP- and LBP+ groups). Radiographic features, including osteophyte (OP), disc height narrowing (DHN), vertebral sclerosis (VS), and spondylolisthesis (SL), were classified between grades of 0–2 grades according to the extent of radiographic changes. The sum of grades at each intervertebral level was designated as the intervertebral grade (IG).

Results
Intra- and inter-observer reliability (kappa coefficient) of OP, DHN, VS, and SL were 0.82–0.92. OP, DHN, VS, and IG grades were significantly higher in the LBP+ group than in the LBP- group. There were no significant differences in KL grades between the LBP- and LBP+ groups. Logistic regression analysis demonstrated that VS grade was a significant independent factor associated with LBP.

Conclusion
The novel elemental grading system of LS would reflect LBP more accurately than the KL classification by individually evaluating each radiographic feature.
Modernizing Costume Design: 1820–1920, Annie Holt (2020)
Authors: Osmond Suzanne 
Published: June 2022

Review of: Modernizing Costume Design: 1820–1920, Annie Holt (2020)
Abingdon: Routledge, 168 pp.,
ISBN 978-0-36715-063-1, h/bk, €158.00, ISBN 978-0-42905-478-5, e-book, €39.00
Género y menores youtubers internacionales en la creación de contenidos. Desafíos más allá de la normativa
Authors: Martín-Casado Teresa-Gema 
Published: June 2022

Si pensamos en el tiempo que pasan los menores frente a las redes sociales, somos conscientes de la necesidad de conocer y controlar al máximo los contenidos que estas redes presentan. Las redes tienen un gran éxito sobre los niños y adolescentes y por ello los contenidos que crean y perciben ejercen un gran poder en su construcción de significados y sentido crítico. En este estudio intentaremos conocer la representación de género que muestran niños y niñas en sus canales de youtube. Para ello hemos seleccionado a las cinco personas menores youtubers que gozan de mayor éxito internacional, con el fin de analizar mediante el método de análisis de contenido: el formato, los estereotipos, tipos de producto, … buscando en ello determinar si la creatividad que construyen niños y niñas es diferente entre sí, fomentando así en sus canales desigualdades de género. Pudiendo comprobar que efectivamente, la creación de contenidos no representa la igualdad, no siempre se da y no se regula ni cuida como relevante.
Operation Bone Rescue—A Case Study of Remediating Flood Damage to Mammal Specimens
Authors: Kuprewicz Erin K. , Muzio Frank M.S. , Nackid Greyson 
Published: June 2022

Abstract
Water damage to natural history collections can result from both natural and human-caused environmental disasters. Floods can result in irreparable damage to scientific specimens, depending on the scale of the disaster, types of specimens affected, and availability of remediation resources. In April 2021, the mammal skeletal collection in the Biodiversity Research Collections (BRC) of the University of Connecticut (UConn) experienced a ceiling flood that affected 612 specimens. In this paper we detail all steps of our specimen rescue process and all materials and equipment we used to complete this remediation in an endeavor we termed “Operation Bone Rescue.” Because we were able to immediately respond to this emergency and implement a complete remediation plan, facilitated by funding from our university, we not only rescued all water-affected specimens, but also improved specimen storage and metadata. We highlight the holistic nature of this successful operation and the key roles played by personnel in the BRC, UConn Facilities Operations, Fire Department, and College of Liberal Arts and Sciences Dean's Office. A deep appreciation of the value of natural history collections is shared widely on our campus and resulted in the favorable outcomes of this complex, coordinated specimen rescue effort.
PENGARUH FASILITAS DAN PENGALAMAN PENGUNJUNG TERHADAP LOYALITAS PENGUNJUNG YANG DIMEDIASI OLEH KEPUASAN PENGUNJUNG (SURVEY PADA PENGUNJUNG WISATA UMBUL PONGGOK KLATEN)
Authors: Aziz Zihni Abdul 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui : (1)Pengaruh fasilitas terhadap loyalitas pengunjung Wisata Umbul Ponggok Klaten, (2)Pengaruh pengalaman pengunjung terhadap loyalitas pengunjung Wisata Umbul Ponggok Klaten, (3)Pengaruh fasilitas melalui kepuasan pengunjung terhadap loyalitas pengunjung Wisata Umbul Ponggok Klaten, (4)Pengaruh pengalaman pengunjung melalui kepuasan pengunjung terhadap loyalitas pengunjung Wisata Umbul Ponggok Klaten. Pengambilan sampel yang digunakan dalam penelitian ini bersifat sampling, di mana hanya wisatawan yang berdomisili Klaten minimal pernah sekali melakukan kunjungan. Jumlah sampel sejumlah 110 orang. Jenis penelitian yang digunakan adalah penelitian kuantitatif dengan metode survey. Metode pengumpulan data yang digunakan dalam penelitian ini adalah kuisoner disusun dengan Skala Likert dan kemudian dihitung dengan metode SPSS. Hasil dari penelitian ini adalah: (1) Fasilitas berpengaruh langsung terhadap loyalitas pengunjung dengan koefisien beta sebesar 0.233 dan hasil signifikan 0.015 ;(2) Pengalaman pengunjung berpengaruh langsung terhadap loyalitas pengunjung dengan koefisien beta sebesar 0,382 dan hasil signifikan sebesar 0,000 ;(3) Fasilitas berpengaruh terhadap loyalitas pengunjung melalui kepuasan pengunjung dengan besar pengaruh total 0,395 dan t hitung sebesar 2,319 < 1,98 (t tabel ) dengan tingkat signifikansi 0,050 ;(4) Pengalaman pengunjung tidak berpengaruh terhadap loyalitas pengunjung melalui kepuasan pengunjung dengan besar pengaruh total sebesar 0,447 dan t hitung sebesar 1,897 < 1,98 dengan tingkat signifkan 0,050
The Neumann and Dirichlet problems for the total variation flow in metric measure spaces
Authors: Górny Wojciech , Mazón José M. 
Published: June 2022

Abstract
We study the Neumann and Dirichlet problems for the total variation flow in doubling metric measure spaces supporting a weak Poincaré inequality. We prove existence and uniqueness of weak solutions and study their asymptotic behavior. Furthermore, in the Neumann problem we provide a notion of solutions which is valid for

L
1

{L^{1}}

initial data, as well as prove their existence and uniqueness. Our main tools are the first-order linear differential structure due to Gigli and a version of the Gauss–Green formula.
On Connes amenable-like properties of dual Banach algebras based on
w
*
w^{*}
-character space
Authors: Sahami Amir , Shariati Seyedeh Fatemeh , Bodaghi Abasalt 
Published: June 2022

Abstract
In this paper, the concept of left ϕ-approximate Connes amenability for a dual Banach algebra

𝒜

{\mathcal{A}}

is studied,
where ϕ is a weak

*

{{}^{*}}

-continuous multiplicative linear
functional on

𝒜

{\mathcal{A}}

. Some characterizations for module extension dual Banach algebras
and matrix algebras are given. Moreover, the notion of approximate left ϕ-Connes biprojectivity for dual
Banach algebras is introduced and some concrete examples regarding this new notion are indicated.
The Nemytskii operator in bounded (p,α)-variation space
Authors: Castillo René Erlin , Ramos-Fernández Julio C. , Trousselot Eduard 
Published: June 2022

Abstract
In this paper, we show that if the Nemytskii operator maps the

(
p
,
α
)

{(p,\alpha)}

-bounded variation space into itself and satisfies some Lipschitz condition, then there are two functions g and h belonging to the

(
p
,
α
)

{(p,\alpha)}

-bounded variation space such that

f
⁢

(
t
,
y
)

=

g
⁢

(
t
)

⁢
y

+

h
⁢

(
t
)

for all
⁢
t

∈

[
a
,
b
]

,

y
∈
ℝ

.

f(t,y)=g(t)y+h(t)\quad\text{for all }t\in[a,b],\,y\in\mathbb{R}.
On a unique solution and stability analysis of a class of stochastic functional equations arising in learning theory
Authors: Turab Ali 
Published: June 2022

Abstract
Numerous computational and learning theory models have been studied using probabilistic functional equations. Especially in two-choice scenarios, the vast bulk of animal behavior research divides such situations into two different events. They split these actions into two possibilities according to the animals’ progress toward a particular decision. However, reward plays a crucial role in such experiments because, based on the selected side and the food placement, such scenarios may be classified into four distinct categories. This article aims to explore the animals’ reactions to such circumstances by presenting a generic stochastic functional equation. By using the well-known fixed point theory results, we examine the existence, uniqueness, and stability of solutions to the suggested functional equation. Moreover, an example is included to emphasize the significance of our findings.
A new class of exact solutions of von Karman’s equation in the nonlinear theory of gas dynamics
Authors: Jokhadze Otar 
Published: June 2022

Abstract
In this paper, by using invariants of Riemann and general solutions of Euler–Poisson–Darboux–Riemann equations, a new class of exact solutions of von Karman’s equation in the nonlinear theory of gas dynamics is given.