bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Dynamic Supramolecular H‐bonding Network with Orthogonally Tunable Clusteroluminescence
Authors: Shi Chen‐Yu , He Dan‐Dan , Wang Bang‐Sen , Zhang Qi , Tian He , Qu Da‐Hui 
Published: November 2022

AbstractEnabling dynamically tunable emissive systems offers opportunities for constructing smart materials. Clusteroluminescence, as unconventional luminescence, has attracted increasing attention in both fundamental and applied sciences. Herein, we report a supramolecular poly(disulfides) network with tunable clusteroluminescence. The reticular H‐bonds synergize the rigidity and mobility of dynamic networks, and endow the resulting materials with mechanical adaptivity and robustness, simultaneously enabling efficient clusteroluminescence and phosphorescence at 77 K. Orthogonally tunable luminescence are achieved in two manners, i.e., slow backbone disulfide exchange and fast side‐chain metal coordination. Further exploration of the reprocessability and chemical closed‐loop recycling of intrinsic dynamic networks for sustainable materials is feasible. We foresee that the synergistic strategy of dynamic chemistry offers a novel pathway and potential opportunities for smart emissive materials.
Triflylpyridinium Enables Rapid and Scalable Controlled Reduction of Carboxylic Acids to Aldehydes using Pinacolborane
Authors: Chen Du , Xu Liangxuan , Yu Yi , Mo Qinliang , Qi Xiaotian , Liu Chao 
Published: November 2022

AbstractBuilding up new and efficient methods for the controlled conversion of carboxylic acids to aldehydes is important. Herein, we report a rapid, modular and scalable method for the conversion of carboxylic acids to aldehydes using pinacolborane at ambient temperature, in which a triflylpyridinium reagent is used. The conversion of carboxylic acid to intermediate acylpyridinium by triflylpyridinium is new. A binary pyridine‐coordinated boronium complex is generated after reduction. The unprecedented reduction of the acylpyridinium by HBpin opens up a practically direct synthesis of aldehydes from carboxylic acids. Theoretical studies indicate that the reduction of acylpyridinium requires a lower activation free energy than that of the product aldehyde. The synthetic advantage of this protocol is further highlighted by the scalable synthesis of aldehyde via continuous flow process. Configuration retention for chiral acids are presented in those syntheses.
Zirconium Carbide Mediates Coke‐Resistant Methane Dry Reforming on Nickel‐Zirconium Catalysts
Authors: Haug Leander , Thurner Christoph , Bekheet Maged F. , Bischoff Benjamin , Gurlo Aleksander , Kunz Martin , Sartory Bernhard , Penner Simon , Klötzer Bernhard 
Published: November 2022

AbstractGraphitic deposits anti‐segregate into Ni0 nanoparticles to provide restored CH4 adsorption sites and near‐surface/dissolved C atoms, which migrate to the Ni0/ZrO2 interface and induce local ZrxCy formation. The resulting oxygen‐deficient carbidic phase boundary sites assist in the kinetically enhanced CO2 activation toward CO(g). This interface carbide mechanism allows for enhanced spillover of carbon to the ZrO2 support, and represents an alternative catalyst regeneration pathway with respect to the reverse oxygen spillover on Ni‐CeZrxOy catalysts. It is therefore rather likely on supports with limited oxygen storage/exchange kinetics but significant carbothermal reducibility.
A Dynamic Thermodynamic Resolution Strategy for the Stereocontrolled Synthesis of Streptonigrin
Authors: Valdez Pérez Luis F. , Bachollet Sylvestre P. J. T. , Orlov Nikolai V. , Kopf Kenji P. M. , Harrity Joseph P. A. 
Published: November 2022

AbstractWe report that axially chiral biaryl boronic esters can be generated with control of atroposelectivity by a Binol‐mediated dynamic thermodynamic resolution process. These intermediates can be progressed to enantioenriched products through stereoretentive functionalization of the carbon–boron bond. Finally, we have exploited this method in the first highly stereoselective total synthesis of P‐streptonigrin.
Evidence of Sulfur Non‐Innocence in [CoII(dithiacyclam)]2+‐Mediated Catalytic Oxygen Reduction Reactions
Authors: Battistella Beatrice , Iffland‐Mühlhaus Linda , Schütze Maximillian , Cula Beatrice , Kuhlmann Uwe , Dau Holger , Hildebrandt Peter , Lohmiller Thomas , Mebs Stefan , Apfel Ulf‐Peter , Ray Kallol 
Published: November 2022

AbstractIn many metalloenzymes, sulfur‐containing ligands participate in catalytic processes, mainly via the involvement in electron transfer reactions. In a biomimetic approach, we now demonstrate the implication of S‐ligation in cobalt mediated oxygen reduction reactions (ORR). A comparative study between the catalytic ORR capabilities of the four‐nitrogen bound [Co(cyclam)]2+(1; cyclam=1,5,8,11‐tetraaza‐cyclotetradecane) and the S‐containing analog [Co(S2N2‐cyclam)]2+(2; S2N2‐cyclam=1,8‐dithia‐5,11‐diaza‐cyclotetradecane) reveals improved catalytic performance once the chalcogen is introduced in the Co coordination sphere. Trapping and characterization of the intermediates formed upon dioxygen activation at the CoIIcenters in1and2point to the involvement of sulfur in the O2reduction process as the key for the improved catalytic ORR capabilities of2.
A Shuttle‐Free Solid‐State Cu−Li Battery Based on a Sandwich‐Structured Electrolyte
Authors: Wang Huimin , Wang Changhong , Zheng Matthew , Liang Jianneng , Yang Ming , Feng Xingyu , Ren Xiangzhong , Yu Denis Y. W. , Li Yongliang , Sun Xueliang 
Published: November 2022

AbstractCu−Li batteries leveraging the two‐electron redox property of Cu can offer high energy density and low cost. However, Cu−Li batteries are plagued by limited solubility and a shuttle effect of Cu ions in traditional electrolytes, which leads to low energy density and poor cycling stability. In this work, we rationally design a solid‐state sandwich electrolyte for solid‐state Cu−Li batteries, in which a deep‐eutectic‐solvent gel with high Cu‐ion solubility is devised as a Cu‐ion reservoir while a ceramic Li1.4Al0.4Ti1.6(PO4)3 interlayer is used to block Cu‐ion crossover. Because of the high ionic conductivity (0.55 mS cm−1 at 25 °C), wide electrochemical window (>4.5 V vs. Li+/Li), and high Cu ion solubility of solid‐state sandwich electrolyte, a solid‐state Cu−Li battery demonstrates a high energy density of 1 485 Wh kgCu−1and long‐term cyclability with 97 % capacity retention over 120 cycles. The present study lays the groundwork for future research into low‐cost solid‐state Cu−Li batteries.
An Infectious Virus‐like Particle Built on a Programmable Icosahedral DNA Framework**
Authors: Xu Yunyun , Yang Yuhe R. , Shi Qian , Ward Andrew B. , Huang Kui , Chen Xiao , Wang Wei , Yang Yang 
Published: November 2022

AbstractViral genomes can be compressed into a near‐spherical nanochamber to form infectious particles. In order to mimic the virus morphology and packaging behavior, we invented a programmable icosahedral DNA nanoframe with enhanced rigidity and encapsulated the phiX174 bacteriophage genome. The packaging efficiency could be modulated through specific anchoring strands adjustment, and the trapped phage genome remained accessible for enzymatic operations. Moreover, the packed complex could infect Escherichia coli (E. coli) cells through bacterial uptake to produce plaques. This rigid icosahedral DNA architecture demonstrated a versatile platform to develop virus mimetic particles for convenient functional nucleic acid entrapment, manipulation and delivery.
Influence of magnetic casting on the permeability and anti‐fouling properties of a novel iron oxide/alumina/polysulfone mixed matrix membrane
Authors: Hashemi Targol , Mehrnia Mohammad Reza , Marandi Aydin , Ismail Ahmad Fauzi 
Published: November 2022

AbstractNovel mixed matrix membranes (MMMs) were fabricated using Fe3O4, and Al2O3nanoparticles (NPs) were added to the polysulfone (PSf) and N‐methylpyrrolidone (NMP) solution. The nanocomposite membranes were fabricated using the NIPS (non‐solvent induced phase separation) method. In order to create preferential permeation pathways for water across the MMMs, membrane formation is accomplished with an external magnetic field. Using magnetic casting cause the targeted placement of NPs in the best location and orientation. The performance of the prepared membranes was examined in terms of pure water flux and fouling parameters. Magnetic casting considerably increased pure water flux and decreased the total resistance of the optimum mixed matrix membrane, which contains 0.2% wt. of Fe3O4NPs to 1175 L/m2h and 13.4 * 1011(m−1), respectively. This is explained by the ordering of magnetic nanoparticles on the membrane sub‐layer cast under the magnetic field of 500 mT, which changed the sub‐layer structure. Less rough membrane surface of the mixed matrix membranes offered preferable anti‐fouling properties against fouling by BSA proteins. The characterization of fabricated membranes was carried out using field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM), energy dispersive X‐ray (EDX), and water contact angle measurement methods.
Dynamic changes of gut bacterial communities present in larvae of Anoplophora glabripennies collected at different developmental stages
Authors: Wang XueFei , Wang HuaLing , Su XiaoYu , Zhang Jie , Bai JiaWei , Zeng JianYong , Li HuiPing 
Published: November 2022

AbstractThe Asian long‐horned beetle, Anoplophora glabripennies (Motschulsky), is a destructive wood‐boring pest that is capable of killing healthy trees. Gut bacteria in the larvae of the wood‐boring pest is essential for the fitness of hosts. However, little is known about the structure of the intestinal microbiome of A. glabripennies during larval development. Here, we used Illumina MiSeq high‐throughput sequencing technology to analyze the larval intestinal bacterial communities of A. glabripennies at the stages of newly hatched larvae, 1st instar larvae and 4th instar larvae. Significant differences were found in larval gut microbial community structure at different larvae developmental stages. Different dominant genus was detected during larval development. Acinetobacter were dominant in the newly hatched larvae, Enterobacter and Raoultella in the 1st instar larvae, and Enterococcus and Gibbsiella in the 4th instar larvae. The microbial richness in the newly hatched larvae was higher than those in the 1st and 4th instar larvae. Many important functions of the intestinal microbiome were predicted, for example, fermentation and chemoheterotrophy functions that may play an important role in insect growth and development was detected in the bacteria at all tested stages. However, some specific functions are found to be associated with different development stages. Our study provides a theoretical basis for investigating the function of the intestinal symbiosis bacteria of A. glabripennies.
Simple and cheap preparation of fluorescence paper sensor based in carbon dot for visual detection of chloramphenicol
Authors: Silva Larissa Franco , Caetano Mayara Martins , de Lima Renata Galvão 
Published: November 2022

AbstractCarbon dots (CDs) are nanometer‐scale particles produced from carbon sources that exhibit fluorescence emission. The present work presents the synthesis and characterization of CDs, as well as the sensing studies for the determination of chloramphenicol (CAP). CAP is an antibiotic used in human medicine and agriculture, and its indiscriminate use and inappropriate disposal have caused damage to human health and the environment. The carbonaceous precursor used in the synthesis of CDs was 3,4‐diaminobenzoic acid (3,4‐DABA) through the hydrothermal method via domestic microwave irradiation. The first synthesis procedure was carried out in the presence of water/ethanol (a‐CDs) and the second in the presence of 1 mol/L sodium hydroxide/ethanol (b‐CDs). The CDs were initially characterized in terms of spectroscopic properties in the ultraviolet and visible region (UV‐visible), Fourier‐transform infrared (FTIR) spectra, Raman spectroscopy, and fluorescence emission spectroscopy. Sensing studies for the antibiotic C were performed by fluorescence suppression in the presence of a‐ and b‐CDs, as well as the precursor 3,4‐DABA. The a‐ and b‐CDs presented similar values of linear range 0.00080–0.0050 mg/ml and limit of detection (LOD) = 0.00030 mg/ml (0.30 ppm) for CAP. Then, a‐ and b‐CDs were embedded in Whatman and Mellita® filter paper, and CAP sensing was evaluated through UV light excitation.
Comparison between ixazomib+cyclophosphamide+dexamethasone regimen and ixazomib+dexamethasone regimen for elderly and frail patients having newly diagnosed multiple myeloma
Authors: Li Shutan , Zhang Duanzhong , Yang Lihua , Huang Chunlan , Niu Ting , Gong Yuping 
Published: November 2022

AbstractAimsThe purpose of this prospective, randomized study was to investigate the effectiveness and safety of the ixazomib+cyclophosphamide+dexamethasone (ICd) and ixazomib+dexamethasone (Id) regimens in newly diagnosed multiple myeloma (NDMM) who were elderly and frail and to compare the two regimens.MethodsPatients were randomly grouped into ICd and Id group. The primary end point was ORR, and patients who received at least two cycles were analyzed. The median follow‐up was 13.5 months. After nine induction cycles, patients were instructed to take single ixazomib for maintenance.ResultsThe overall response rate in the ICd and Id groups was 78.9% and 70.6%, respectively, whereas the very good partial remission or better rate was 47.4% and 23.5%, respectively. For the ICd and Id groups, the response rate after 4 cycles was 76.5% and 57.1%, and the median duration to response was 2 and 4 months, respectively. Adverse events (AEs) included gastrointestinal intolerance, rash, fatigue, and thrombocytopenia, with severe AEs occurring in 21.1% and 23.5% patients in the ICd and Id groups, respectively, and the AEs were manageable. Both the QLQ‐C30 and QLQ‐MY20 scales indicated that ICd and Id regimens could help maintain and improve the quality of life(QoL).ConclusionsThe ICd and Id regimens might be effective and well‐tolerated in elderly and frail patients with NDMM. In addition, a favorable outcome was observed that ICd might tend to cause faster and higher remission than Id regimen without increasing the risk of AEs. The long‐term effectiveness and safety of the two regimens need further investigation.
Phenolic Compounds from the Fruits of Prunus davidiana (Rosaceae) and Their Antioxidant Activities
Authors: Lee Min‐Jee , Lee Yeong‐Geun , Lim You Jin , Seo Kyeong‐Hwa , Eom Seok‐Hyun , Kang Se Chan , Baek Nam‐In , Lee Youn‐Hyung 
Published: November 2022

AbstractThis research was supported by Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ014204032019) and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF‐2020R1A6A3A01100042).
Underweight and obesity are related to higher mortality in patients undergoing coronary angiography: The KARDIO invasive cardiology register study
Authors: Laukkanen Jari A. , Kunutsor Setor K. , Hernesniemi Jussi , Immonen Jaakko , Eskola Markku , Zaccardi Francesco , Niemelä Matti , Mäkikallio Timo , Hagnäs Magnus , Piuhola Jarkko , Juvonen Jukka , Sia Jussi , Rummukainen Juha , Kervinen Kari , Karvanen Juha , Nikus Kjell ,   KARDIO Study Group
Published: November 2022

AbstractBackgroundIn patients with some cardiovascular disease conditions, slightly elevated body mass index (BMI) is associated with a lower mortality risk (termed “obesity paradox”). It is uncertain, however, if this obesity paradox exists in patients who have had invasive cardiology procedures. We evaluated the association between BMI and mortality in patients who underwent coronary angiography.MethodsWe utilised the KARDIO registry, which comprised data on demographics, prevalent diseases, risk factors, coronary angiographies, and interventions on 42,636 patients. BMI was categorised based on WHO cut‐offs or transformed using P‐splines. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated for all‐cause mortality.ResultsDuring a median follow‐up of 4.9 years, 4688 all‐cause deaths occurred. BMI was nonlinearly associated with mortality risk: compared to normal weight category (18.5–25 kg/m2), the age‐adjusted HRs (95% CIs) for all‐cause mortality were 1.90 (1.49, 2.43), 0.96 (0.92, 1.01), 1.04 (0.99, 1.09), 1.08 (0.96, 1.20), and 1.45 (1.22, 1.72) for underweight (<18.5 kg/m2), preobesity (25 to <30 kg/m2), obesity class I (30 to <35 kg/m2), obesity class II (35 to <40 kg/m2), and obesity class III (>40 kg/m2), respectively. The corresponding multivariable adjusted HRs (95% CIs) were 2.00 (1.55, 2.58), 0.92 (0.88, 0.97) 1.01 (0.95, 1.06), 1.10 (0.98, 1.23), and 1.49 (1.26, 1,78), respectively.ConclusionsIn patients undergoing coronary angiography, underweight and obesity class III are associated with increased mortality risk, and the lowest mortality was observed in the preobesity class. It appears the obesity paradox may be present in patients who undergo invasive coronary procedures.
Chronic total occlusion percutaneous coronary intervention in heart transplant patients
Authors: Azzalini Lorenzo , Moroni Francesco , Dawson Kathryn L. , Kearney Kathleen E. 
Published: November 2022

AbstractCardiac allograft vasculopathy (CAV) is frequently observed after heart transplant (HT), and represents one of the main causes of chronic rejection, graft loss, and death. While the role of percutaneous coronary intervention (PCI) is well established in the management of CAV in cases of nonocclusive stenoses, the outcomes and technical aspects of this procedure in chronic total occlusions (CTOs) are unknown. We describe our experience with three cases in which CTO PCI was indicated to treat CAV in HT recipients, and we discuss the peculiarities and therapeutic approach to this challenging patient population. In particular, all patients were asymptomatic for angina, and CTO PCI was indicated to promote recovery of left ventricular function, extend graft survival, and/or protect from future ischemic events. CTO PCI was performed using hybrid techniques and was successful in all three cases. Intravascular imaging was used in all cases to maximize the durability of the procedure.
Impact of acute coronary syndrome on clinical outcomes after revascularization with the dual‐therapy CD34 antibody‐covered sirolimus‐eluting Combo stent and the sirolimus‐eluting Orsiro stent
Authors: Jakobsen Lars , Christiansen Evald H. , Freeman Phillip , Kahlert Johnny , Veien Karsten , Maeng Michael , Raungaard Bent , Ellert Julia , Kristensen Steen D. , Christensen Martin K. , Terkelsen Christian J. , Thim Troels , Eftekhari Ashkan , Jensen Rebekka V. , Støttrup Nicolaj B. , Junker Anders , Hansen Henrik S. , Jensen Lisette O. 
Published: November 2022

AbstractObjectivesTo compare the efficacy and safety of the dual‐therapy CD34 antibody‐covered sirolimus‐eluting Combo stent (DTS) and the sirolimus‐eluting Orsiro stent (O‐SES) in patients with and without acute coronary syndrome (ACS) included in the SORT OUT X study.BackgroundThe incidence of target lesion failure (TLF) after treatment with modern drug‐eluting stents has been reported to be significantly higher in patients with ACS when compared to patients without ACS. Whether the results from the SORT OUT X study apply to patients with and without ACS remains unknown.MethodsIn total, 3146 patients were randomized to stent implantation with DTS (n = 1578; ACS: n = 856) or O‐SES (n = 1568; ACS: n = 854). The primary end point, TLF, was a composite of cardiac death, target‐lesion myocardial infarction (MI), or target lesion revascularization (TLR) within 1 year.ResultsAt 1 year, the rate of TLF was higher in the DTS group compared to the O‐SES group, both among patients with ACS (6.7% vs. 4.1%; incidence rate ratio: 1.65 [95% confidence interval, CI: 1.08–2.52]) and without ACS (6.0% vs. 3.2%; incidence rate ratio: 1.88 [95% CI: 1.13–3.14]). The differences were mainly explained by higher rates of TLR, whereas rates of cardiac death and target lesion MI did not differ significantly between the two stent groups in patients with or without ACSConclusionCompared to the O‐SES, the DTS was associated with a higher risk of TLF at 12 months in patients with and without ACS. The differences were mainly explained by higher rates of TLR.
Comparison of outcomes in patients with or without ARC‐HBR criteria undergoing PCI with polymer‐free biolimus coated stents: The BioFreedom France study
Authors: Garot Philippe , Brunel Philippe , Dibie Alain , Morelle Jean‐François , Abdellaoui Mohamed , Levy Raphy , Carrié Didier , Karsenty Bernard , Robin Christophe , Berland Jacques , Copt Samuel , Sadozai Slama Sara , Oldroyd Keith , Morice Marie‐Claude , Lipiecki Janusz ,   the BioFreedom France Investigators
Published: November 2022

AbstractBackgroundThe polymer‐free biolimus coated stent (BioFreedom) was shown to be superior to bare metal stents in the LEADERS FREE randomized trial in high bleeding risk (HBR) patients treated with 1‐month dual antiplatelet therapy (DAPT). However, there is limited outcome data with this device in an all‐comers' population.MethodsWe conducted a prospective single‐arm study of patients undergoing percutaneous coronary intervention with the polymer‐free biolimus coated stent in 25 centers in France with wide inclusion criteria including multivessel disease, complex lesions, and acute coronary syndromes. The primary endpoint was the incidence of target lesion failure (TLF), a composite of cardiac death or target‐vessel myocardial infarction (MI) or clinically indicated target lesion revascularization (ci‐TLR) at 1‐year. The patient population was classified according to the presence (or not) of HBR criteria according to the recent ARC‐HBR definition.ResultsBetween April 2019 and April 2020, 1497 patients were enrolled. TLF occurred in 101 (6.9%) patients, including cardiac death in 35 (2.4%), target vessel MI in 20 (1.4%) and ci‐TLR in 65 (4.5%) of them. There were 491 HBR patients (32.8%) and 1006 non‐HBR patients. The median duration of DAPT was 74 days in the HBR group versus 348 days in the non‐HBR group (p < 0.0001). TLF occurred in 44 (9.2%) of the HBR group and in 57 (5.8%) of the non‐HBR group (relative risk 1.62 [95% confidence interval: 1.10–2.41], p = 0015). Compared to the non‐HBR group, HBR patients had higher rates of cardiac death (4.4% vs. 1.4%, p = 0.0005) and target vessel MI (2.9% vs. 0.6%, p = 0.0003), but similar rates of ci‐TLR. BARC 3–5 bleeding occurred in 6.2% of the HBR group versus 1.4% of the non‐HBR group (p < 0.0001).ConclusionIn this multicenter all‐comers study, HBR patients treated with a polymer‐free biolimus coated stent had, compared to non‐HBR patients, an increased risk of cardiac death and MI, and despite a shorter duration of DAPT, continued to have higher rates of BARC 3–5 bleeding.
Unrecoverable stent deformation in the left main: Crush it or remove it?
Authors: Achim Alexandru , Krivoshei Lian , Leibundgut Gregor 
Published: November 2022

AbstractSerial ostial and distal left main lesions continue to be one of the most difficult tasks for the interventional cardiologist, with many potential complications occurring. We present such a high‐risk percutaneous coronary intervention where immediate stent explantation was deemed necessary because the metal deformation and high radial strength of the particular stent platform would prevent an acceptable procedural result if it had been crushed to the vessel wall. The aim of this paper was to discuss left main stent deformation, debate the risks and benefits of stent explantation and finally test in‐vitro our theory on “insufficient” crush with stents with high radial strength and compare it with conventional stents. Bench‐testing supports our ad‐hoc explantation decision showing stent underexpansion, recoil, and malapposition, obtaining an inadequate minimal stent area.