bluuebunny/crossref_metadata_2025_split huggingface dataset:
Night Eating Syndrome Subtypes: Differences in Binge Eating and Food Addiction Symptoms
Authors: Echeverri Brenda , Kozak Andrea T , Gildner Daniel J , Pickett Scott M 
Published: April 2022

Abstract
Purpose
The purpose of the current study was to examine differences in binge eating and food addiction symptoms between NES latent subtypes: evening hyperphagia with nocturnal ingestions (EHNI), evening hyperphagia-only (EHO; without nocturnal ingestions), and nocturnal ingestions-only (NIO; without evening hyperphagia). It was hypothesized that the EHNI group would report more binge eating behaviors and more food addiction symptoms than both the EHO and NIO groups. Further, it was hypothesized that the EHO and NIO groups would differ with the EHO group reporting more binge eating behaviors and the NIO group reporting more food addiction symptoms.
Methods
Participants completed measures online relating to night eating, binge eating, and food addiction symptoms. Responses to the NEQ (Allison et al., 2008) were used to create an EHNI group (n = 65), an EHO group (n = 32), and a NIO group (n = 69). ANOVAs were conducted to examine between-group differences on disordered eating symptoms.
Results
The results indicated that participants in the EHNI group reported more severe binge eating and food addition symptoms than those in the EHO and NIO groups. However, there were no significant differences in binge eating or food addiction between the EHO and NIO groups.
Conclusion
Individuals who meet both NES core criteria (evening hyperphagia and nocturnal ingestions) appear to be at a higher risk for experiencing more severe binge eating symptoms and meeting suggested criteria for food addiction diagnosis. Implications concerning assessment, treatment, and prevention for NES subtypes and comorbidities are discussed.
Level of Evidence:
Level V, cross-sectional descriptive study
Continuous activation of β1-AR/CaMKII pathway is participated in HHcy-induced myocardial injury
Authors: Chai Jiayin , Zhao Yuhui , Yan Wenjing , Xue Ke , Chen Shuai , Zhu Xinyu , Li Yan , Wang Wen 
Published: April 2022

Abstract
Purpose Although hyperhomocysteinemia（HHcy）is regarded as an independent risk factor for cardiovascular diseases, the role of HHcy in the development of heart failure has not been clarified yet. During the occurrence and progression of heart failure, usually the β1-adrenergic receptor（β1-AR）is activated continuously. Here we aim to evaluate the association of hyperhomocysteinemia with continuous activation of β1-AR in heart. Methods HHcy models were established by feeding mice with 2.5% methionine diet for 7 months, and HHcy+metoprolol group was established by feeding mice with 2.5% methionine diet and treating with metoprolol (15mg/Kg) through intragastric administration. Echocardiography was used to evaluate the cardiac function after 2, 6, and 7 months feeding. Myocardial injury was assessed by serum myocardial enzyme level. Myocardial ultrastructure was assessed by transmission electron microscopy. The activation level of β1-AR signal pathway was analyzed using immunoprecipitation and western blot. H9c2 cardiomyocytes and neonatal rat cardiomyocytes were treated with Hcy (500 μM) or metoprolol (100 μM) for 5-60 minutes or 48 hours separately. Results In HHcy mice, the cardiac function was decreased, the serum myocardial enzyme level was increased and the myocardial ultrastructure was destroyed, which could be alleviated by β1-AR receptor blocker metoprolol. Hcy activated the cardiac β1-AR signaling pathway, the downstream PKA signaling pathway was activated by Hcy stimulation within 5-60 min, and the CaMKII signaling pathway could be activated at 48h. Conclusion Continuous activation of β1-AR/CaMKII pathway is participated in HHcy-induced myocardial injury, which can be alleviated by β1-AR receptor blocker.
Can electrophysiological studies predict multiple sclerosis prognosis?
Authors: beton ozlem , Mungan Semra Ozturk 
Published: April 2022

Abstract
Background: Multiple sclerosis (MS) is an autoimmune neurodegenerative disease with an unpredictable course. MS lesions can affect the evoked potentials of electrophysiological studies. In this study we aimed to predict the prognosis of MS patients with electrophysiological parameters.Methods: MS patients with Visual Evoked Potentials (VEP) and Somatosensorial Evoked Potentials (SEP) were included in the study during two years period. Demographic characteristics, MS type, attack numbers, current Expanded Disability Status Scales (EDSS), electrophysiological evoked potentials (EP), blood tests, first cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) findings of the patients were evaluated.Results: Two hundred and fifty-nine MS patients were evaluated. There was a statistically significant difference between EDSS scores and the pathologies detected in both electrophysiological examinations (p:0.000). The number of MS attacks were only associated with tibial SEP pathologies (p:0.045). IgG index of CSF had no significant effect on VEP (p:0.065) but had a statistically significant effect on posterior tibial SEP. Posterior tibial SEP was statistically significant in two-sided abnormalities in MS patients with an elevated IgG index (p:0.039). MS patients who met the International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria had two-sided abnormalities that were statistically significant on both VEP and tibial SEP examinations (p:0.003 and 0.000 respectively). Patients who had pathology in electrophysiological examinations at the beginning have statistically significantly more frequent demyelinating lesions in spinal and infratentorial according to current MRI.Conclusion: Evoked potentials can predict clinical deterioration in MS patients.Neurophysiological abnormalities can be considered in MS disease as prognostic factor.
Locking intramedullary nailing for the treatment of severely displaced two-part surgical neck fractures of the proximal humerus: factors influencing outcomes in elderly patients
Authors: Asano Kenichi , Hiraiwa Hideki , Hidaka Satoki , Asami Yuta 
Published: April 2022

Abstract
Background: 2-part surgical neck fractures of the proximal humerus were treated using the locking intramedullary nail. The purpose of this study was to evaluate the clinical outcomes in elderly patients and to assess which factors are associated with the outcomes.Methods: Forty seven patients who were 60 years of age or older were included in this study. All patients with severely displaced 2-part proximal humeral fractures were treated using a locking intramedullary nail. The average age of the patients was 72 years and the average follow-up period was 25 months. We assessed fracture healing, head-shaft angulation on radiograph, and complications. Japan Orthopaedic Association shoulder score was used to assess clinical outcomes. Statistical significance was determined using multiple regression analysis, Student t-test and Mann-Whitney U test.Results: Radiographic fracture healing was obtained in all patients. The average head-shaft angulation was 129°. Complications included osteonecrosis in 1 patient. The average Japan Orthopaedic Association shoulder score was 87.3 points. In multiple regression analysis, head-shaft angulation was associated with significantly poor clinical outcomes (p =0.048). A lower head-shaft angulation was associated with significantly poor shoulder score especially in range of motion of the shoulder joint (p =0.012).Conclusions: The technique of locking intramedullary nailing for elderly patients gives satisfactory results, and has a low rate of complications. Postoperatively, we should pay attention to varus angulation as it was associated with significantly poor shoulder function in the treatment of 2-part surgical neck fractures.Trial registration: All patients were retrospectively registered in this study.
Experimental Investigation of Wire Arc Additive Manufacturing of Inconel 625 Using Spot Welding
Authors: Votruba Vojtěch , Diviš Ivan , Pilsová Lucie , Zeman Pavel , Beránek Libor , Horváth Jakub , Smolík Jan 
Published: April 2022

Abstract
Additive manufacturing (AM) is a progressive technology which holds promise for manufacturing of heat resistant super alloys. One of the most productive methods is Wire Arc Additive Manufacturing (WAAM). In this article an alternative WAAM welding strategy is investigated. Experimental welds and material tests were performed to evaluate the material properties obtained through a GMAW CMT spot welding strategy used in WAAM of Inconel 625 alloy. The GMAW CMT spot welding strategy has lower productivity and a higher consumption of shielding gas. However, it excels in low heat input and precise material cladding in comparison with a standard GMAW CMT continuous welding strategy. It enables fabrication of finer details even on thin walled components or in sections with problematic heat dissipation. Samples manufactured using this strategy were also compared with samples manufactured through a standard GMAW CMT continuous welding strategy. Two sets of manufactured samples were thus tested. The following material tests were performed: i) metallographic analysis, ii) x-ray tomography, iii) SEM analysis, iv) hardness, v) tensile strength (20°C, 650°C), and vi) pin-on-disc (20°C, 650°C). The results show that the spot welding strategy led to improved material properties in the Inconel 625 samples. Ultimate tensile strength improved by 15% at 20°C and by 4% at 650°C. Wear resistance at 650°C was about two times higher. This paper concludes that the GMAW CMT spot welding strategy for Inconel 625 is definitely suitable for WAAM manufacturing of complex shapes, fine details and thin walled components.
Diagnostic efficiency of adropin as a preliminary test to exclude acute pulmonary embolism: a prospective study
Authors: Orun Serhat , Celikkol Aliye , Basol Batuhan Ilbey , Yeniay Elif 
Published: April 2022

Abstract
Background: This study aims to investigate the efficiency of adropin as a biomarker to exclude the diagnosis of acute pulmonary embolism. Methods: Patients admitted to the emergency department of a tertiary health center (a university hospital) between August 2019 and August 2020 and diagnosed with pulmonary embolism were included in this prospective cohort study. The amount of serum adropin was determined in patients with pulmonary embolism (who were diagnosed using computerized tomography pulmonary angiography) and compared with healthy volunteers. Results: There were 57 participants in the study (28 controls and 29 PE patients). The mean value of the adropin level in the pulmonary embolism group was 187.33 ± 62.40 pg/ml which is significantly lower than the control group (524.06 ± 421.68 pg/ml) (p < 0.001). When the optimal adropin cut-off value was 213.78 pg/ml, the likelihood ratio of the adropin test was 3.4, and the sensitivity of the adropin test at this value was 82% with specificity of 75% (95% CI; AUC: 0.821). Conclusion: The adropin test can be used to exclude the diagnosis of acute pulmonary embolism in the emergency department. However, more research is required to verify and support the generalizability of our study results.
Dry matter partitioning of Rice crop as influenced by Date of planting and Nutrient Management
Authors: Patra Bishnupriya , Jena Satyananda , Mishra Prasannajit , Sahoo Hemanta kumar , Gantayat B.P. , Mangaraj Satyabrata 
Published: April 2022

Abstract
Dry matter accumulation reflects growth and metabolic efficiency of a plant, which ultimately influences the economic yield. A 2-year field experiment was conducted at the Agronomy research farm of Orissa University of Agriculture and Technology, Bhubaneswar, Odisha during 2018 (Y1) to 2019 (Y2) having subhumid climate. Experiment was designed to evaluate the effect of two date of planting (D1: 10 July, D2: 25 July) which were allotted to main plots and 3 combinations of Nutrient management (N1: STBFR, N2: STBFR + GM, N3: STBFR + FYM) allotted for Sub plots on Rice crop (Naveen). Early planting (15 days ahead) shows significant improvement in Leaf, stem, panicle over late planting while significantly higher drymatter accumulation in different plant parts were optimized under STBFR + GM method of nutrient management. Among all the plant parts Stem shows higher accumulation of dry weight than other plant parts, However Early planting and application of STBFR + GM was recommended for higher drymatter accumulation of Rice crop.
Does the toxicity of endocrine therapy persist into long-term survivorship? – Patient-reported outcome results from a follow-up study beyond a 10-year-survival
Authors: Albertini Carmen , Oberguggenberger Anne , Sztankay Monika , Egle Daniel , Giesinger Johannes , Meraner Verena , Hubalek Michael , Brunner Christine 
Published: April 2022

Abstract
Background: Endocrine treatment (ET) is a highly effective breast cancer treatment but can distinctly impair breast cancer patients’ quality of life (QOL). In a patient-reported outcome (PROs) study conducted by the authors in 2011, patients reported higher ET-induced symptom levels than known from the registration trials, and was underestimated. Based on these study results, we investigated the long-term sequelae of ET reported by breast cancer survivors (BCS) in a follow-up study conducted 5-10 years after an earlier assessment.Methods: BCS who had participated in the earlier study (n=436) were approached for study participation; consenting patients were asked to completed the same PRO assessment used in the original study (FACT-B+ES). BCS with relapse/ progressive disease were excluded from the analysis. We compared long-term endocrine symptomatology and overall QOL outcome (i.e. FACT-G and -ES sum score).Results: A final sample of 268 BCS was included in the analysis. BCS reported a significant improvement of the overall endocrine symptomatology (baseline mean=59 vs. follow-up mean=62, p<0.001), physical (baseline=23.9 mean vs. follow-up mean=24.8, p<0.01) and functional well-being (baseline mean=21.7 vs. follow-up mean=22.7, p=0.013) and overall QOL (mean baseline=88.3 vs. mean follow-up=90.9, p=0.011). However, the prevalence of particular symptoms, well-known to be ET induced, did not change over time such as joint pain (baseline=45.5% vs. 44.2%, n.s. difference), lack of energy (36.4% vs 33.8%, n.s. difference), weight gain (36.8% vs. 33.9%, n.s. difference) or vaginal dryness (30.2% vs. 33%, n.s. difference) and loss of interest in sex even deteriorated over time (40.4% vs. 48.7%, p<0.05).Conclusion: Presented results indicate that BCS recover well in terms of overall endocrine symptomatology and quality of life but experience some clinically relevant and unfavorable ET related long-term effects.
Using CUSUM in Real Time to Signal Clinically Relevant Decreases in Estimated Glomerular Filtration Rate
Authors: Zafarnejad Reyhaneh , Dumbauld Steven , Dumbald Diane , Adibuzzaman Mohammad , Griffin Paul , Rutsky Edwin 
Published: April 2022

Abstract
Background The electronic health record (EHR), utilized to apply statistical methodology, assists provider decision-making, including during the care of chronic kidney disease (CKD) patients. When estimated glomerular filtration (eGFR) decreases, the rate of that change adds meaning to a patient’s single eGFR and may represent severity of renal injury. Since the cumulative sum chart technique (CUSUM), often used in quality control and surveillance, continuously checks for change in a series of measurements, we selected this statistical tool to detect clinically relevant eGFR decreases and developed CUSUMGFR.Methods In a retrospective analysis we applied CUSUMGFR to signal identification of eventual ESKD patients prior to diagnosis date. When the patient signaled by reaching a specified threshold CUSUMGFR value, days from CUSUMGFR signal date to ESKD diagnosis date were measured, along with the corresponding eGFR measurement at the signal. Results Signaling occurred 790 days prior to ESKD diagnosis date with sensitivity of 0.830 and specificity of 0.910. Mean days prior to ESKD diagnosis were significantly greater in Black patients (875 ), and in patients with hypertension (849 ), diabetes (940 ), cardiovascular disease (1037 ), and hypercholesterolemia (971 ). Sensitivity and specificity did not vary by sociodemographic and clinical risk factors.Conclusions CUSUMGFR correctly identified nearly 25% of CKD patients destined for ESKD when eGFR was > 60 ml/min/1.73 m2. If utilized in an EHR, signaling patients could focus providers’ efforts to slow or prevent progression to ESKD.
Stratigraphical reassessment of Grotta Romanelli sheds light on Middle-Late Pleistocene palaeoenvironments, sea-level history and human settling in the Mediterranean
Authors: Pieruccini Pierluigi , Forti Luca , Mecozzi Beniamino , Iannucci Alessio , Yu Tsai-Luen , Shen Chuan-Chou , Bona Fabio , Lembo Giuseppe , Muttillo Brunella , Sardella Raffaele , Mazzini Ilaria 
Published: April 2022

Abstract
During the last century, Grotta Romanelli (Southern Italy) has been a reference site for the European Late Pleistocene stratigraphy, due to its geomorphological setting and archaeological and palaeontological content. The beginning of the sedimentation inside the cave was attributed to MISs 5e and the oldest unearthed evidence of human occupation, including remains of hearths, was therefore referred to the Middle Palaeolithic. Recent surveys and excavations produced new U/Th dates, palaeoenvironmental interpretation and a litho-, morpho- and chrono-stratigraphical reassessment, placing the oldest human frequentation of the cave between MIS 9 and MIS 7, therefore embracing Glacial and Interglacial cycles. These new data provide evidence that the sea reached the cave during the Middle Pleistocene and human occupation occurred long before MISs 5e and persisted beyond the Pleistocene- Holocene boundary.
Cancer Care Unit Missed Care and Related Factors: View of Nurses of Southeast Iran
Authors: Shamsi Ala , Anari Mahlagha Dehghan , Canillas-Dufau Tori , Forouzi Mansooreh Azzizadeh 
Published: April 2022

Abstract
Introduction: A key element affecting care quality is missed or unfinished care, especially in oncology departments. This study aimed to evaluate missed care and related factors in oncology wards of southeast Iran.Methods: This study was conducted in five cities located in southeastern Iran. Ninety-three (93) health care providers of oncology departments participated in this study. Missed nursing care and related factors questionnaires were used for data collection. SPSS 22 was utilized to perform descriptive and inferential statistics. The significance level was set at p<0.05.Results: Study results revealed that the highest missed nursing care was “Participation in interdisciplinary patient care conferences” (2.82 ± 1.08), and “Supervision of food preparation for the patient who can eat on his own” (2.67 ± 1.30). The highest reason of missed care was an “Unexpected increase in the number of patients or crowded wards” (3.78 ± 0.69) and “High volume of activities related to patient admission and discharge” (3.73 ± 0.58). Study findings also showed a significant relationship between missed nursing care and city.Conclusion: According to the study results, allocating sufficient nursing staff to oncology wards can provide sufficient time for caregivers, resulting in decreased missed care which has been documented to contribute to increased quality of care, and improved patient safety.
Effects of smoking on the retina in of patients with dry age-related macular degeneration by optical coherence tomography angiography
Authors: Yang Weizhou , Song Chunyuan , Gao Meng , Wang Shuna , Yu Haonan , Li Yan 
Published: April 2022

Abstract
Purpose: The macula of the retina is analysed using optical coherence tomography angiography (OCTA) to provide clinical basis and explain the mechanism of smoking as a risk factor in dry age-related macular degeneration (AMD). Materials and Methods: This cross-sectional study included 49 normal control nonsmokers, 12 normal control smokers, 38 dry AMD nonsmokers and 35 dry AMD smokers. The foveal avascular zone (FAZ), foveal density (FD) in a 300 μm region around FAZ, vessel densities of the superficial (SCP) and deep (DCP) capillary plexuses and central fovea retinal thickness (FRT) were compared using OCTA. The bivariate correlation analysis was used to evaluate the effect of pack–year history on retina-related indices. Results: The vessel densities of whole, foveal and parafoveal of SCP and whole and parafoveal of DCP in the control nonsmoking group were all significantly higher than those in the dry AMD nonsmoking group (all P < 0.05), whereas the whole vessel density of SCP in the normal smoking group was higher than that in the dry AMD smoking group (P = 0.04). The thickness values of the inner and full-layer FRT in the normal nonsmoking group were significantly thicker than those in the dry AMD nonsmoking group (all P < 0.01). The pack–year history was negatively correlated with the parafoveal vessel density of DCP (r = −0.224, P < 0.01). Conclusions: FD, SCP, DCP and FRT are sensitive indices for the detection of early and intermediate dry AMD. DCP is a sensitive indicator that reflects the effects of smoking on the retina. Considerable changes are observed in retinal vessels, suggesting that dry AMD may affect the retinal tissue to a certain extent.
Fusion of AraBERT and DF-GAN for Arabic Text to Image Generation
Authors: BAHANI Mourad , OUAAZIZI Aziza EL , MAALMI Khalil 
Published: April 2022

Abstract
Current AI systems have shown impressive results in the Automatic synthesis of high-resolution realistic images from texts descriptions. Specifically, Generative Adversarial Networks (GANs) as a powerful technology that utilizes computer vision tools to create two models, the Generator that generates realistic images and the discriminator that distinguishes whether the images synthesized are real or fake. Further, Most text-to-image generation frameworks leverage the power of GANs to generate realistic images conditioned with texts descriptions. In this paper, we fuse a sample and efficient text-to-image generation framework called DF-GAN and AraBERT architecture to generate images conditioned with Arabic texts descriptions. Firstly, we recreate new datasets matching the Arabic text-to-image generation task by applying super translation using the DeepL-Translator from English to Arabic on texts descriptions. Secondly, we leverage the power of AraBERT which is trained on billions of Arabic words to produce a strong sentence embedding, and we reduce that vector’s dimension to match with DF-GAN shape. Thirdly, we inject the reduced sentence embedding into the DF-GAN framework to generate high-resolution realistic, and text-matching images conditioned with Arabic texts descriptions. Such as in previous work, we use CUB and Oxford-102 flowers as original datasets. Further, we measure our framework with FID and IS. Our framework is the first that achieve much success in generating high-resolution realistic and text matching images conditioned with Arabic text.