bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relapse after nonmetastatic rhabdomyosarcoma: Salvage rates and prognostic variables
Authors: Bergamaschi Luca , Chiaravalli Stefano , Livellara Virginia , Sironi Giovanna , Puma Nadia , Nigro Olga , Gattuso Giovanna , Luksch Roberto , Terenziani Monica , Spreafico Filippo , Meazza Cristina , Podda Marta , Biassoni Veronica , Schiavello Elisabetta , Hovsepyan Shushan , Morosi Carlo , Vennarini Sabina , Massimino Maura , Casanova Michela , Ferrari Andrea 
Published: October 2022

AbstractBackgroundPatients with relapsing rhabdomyosarcoma (RMS) pose a therapeutic challenge, and the survival rate is reportedly poor. We describe a retrospective series of relapsing RMS patients treated at a referral center for pediatric sarcoma, investigating the pattern of relapse, salvage rates, and factors correlating with final outcomes.MethodsThe analysis concerned 105 patients <21 years old treated from 1985 to 2020 with initially localized RMS at first relapse. For risk‐adapted stratification purposes, patient outcomes were examined using univariable and multivariable analyses based on patients’ clinical features at first diagnosis, first‐line treatments, clinical findings at first relapse, and second‐line treatments.ResultsFirst relapses occurred 0.08–4.8 years (median 1 year) following initial diagnosis and were local/locoregional in 59% of cases. Treatment at first relapse included chemotherapy in all but two cases, radiotherapy in 38, and surgery in 21. Median event‐free survival (EFS) after first relapse was 4 months, while 5‐year EFS was 16.3%; median overall survival (OS) was 9 months, while 5‐year OS was 16.7%. Several variables influenced survival rates. Considering only clinical findings and treatment at relapse, Cox's multivariable analysis showed that OS correlated significantly with time to relapse, radiotherapy administered at relapse, response to chemotherapy, and whether a second remission was achieved.ConclusionSurvival following first relapse of patients with localized RMS at initial diagnosis is poor. The variables found to influence survival can be utilized in a risk‐adapted model to estimate the chances of salvage to guide decisions for second‐line treatments.
Porous anion exchange membranes fabricated by phase inversion and in‐situ modification for acid recovery
Authors: You Xinqiang , Chen Jiaqi , Teng Lin , Lin Jiuyang , Lin Xiaocheng 
Published: October 2022

AbstractDiffusion dialysis (DD) for acid recovery is significantly restricted by the poor acid dialysis coefficient () of anion exchange membranes (AEMs). To overcome such problem, porous AEMs with extremely high free space volume have been fabricated herein based on porous membrane substrate, drawing inspiration from the dissolution‐diffusion concept. Specifically, chloromethylated polyethersulfone (CMPES) has been used as the starting material to create the porous substrate via non‐solvent phase inversion, then in‐situ crosslinked and quaternized using ethylenediamine (EDA) and N‐methylimidazole (NMI), respectively. In this study, the degrees of modification of EDA and NMI are controlled to adjust the microstructure and DD performance of the produced porous AEMs. The ideal AEM's and acid/salt separation factor (S) are 4.3 and 2.6 times greater, respectively, than those of the commercial DF‐120 membrane at the same condition. Additionally, it shows strong organic solvent resistance and thermal stability, and therefore demonstrate the potential for widespread use.
Generation of neutral pH high‐strength plasma‐activated water from a pin to water discharge and its bactericidal activity on multidrug‐resistant pathogens
Authors: N. Punith , Singh Ashish K. , J. Ananthanarasimhan , Boopathy Bhavadharini , Chatterjee Ritika , M. Hemanth , Chakravortty Dipshikha , Rao Lakshminarayana 
Published: October 2022

AbstractPlasma‐activated water (PAW) is emerging as a green alternative technology in biomedicine due to its rich and diverse aqueous reactive nitrogen and oxygen species (RONS). This study explores how to configure a pin to water (P2W) discharge to generate neutral pH high‐strength plasma‐activated water (hs‐PAW) and its bactericidal activity on hypervirulent multidrug resistance (MDR) pathogens. The factors affecting the strength of PAW, namely: water type, PAW temperature, plasma enclosure, and activation time, were studied and optimized to generate hs‐PAW having 650 ± 40 mg/l of and 215 ± 15 mg/l of H2O2 at a pH of 7. This study demonstrates a simple P2W discharge set up to handle the MDR pathogens and can be easily scalable for real‐world medical applications.
Characterization of the Escherichia coli pyridoxal 5′‐phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability
Authors: Tramonti Angela , Ghatge Mohini S. , Babor Jill T. , Musayev Faik N. , di Salvo Martino Luigi , Barile Anna , Colotti Gianni , Giorgi Alessandra , Paredes Steven D. , Donkor Akua K. , Al Mughram Mohammed H. , de Crécy‐Lagard Valérie , Safo Martin K. , Contestabile Roberto 
Published: October 2022

AbstractThe pyridoxal 5′‐phosphate (PLP) homeostasis protein (PLPHP) is a ubiquitous member of the COG0325 family with apparently no catalytic activity. Although the actual cellular role of this protein is unknown, it has been observed that mutations of the PLPHP encoding gene affect the activity of PLP‐dependent enzymes, B6 vitamers and amino acid levels. Here we report a detailed characterization of the Escherichia coli ortholog of PLPHP (YggS) with respect to its PLP binding and transfer properties, stability, and structure. YggS binds PLP very tightly and is able to slowly transfer it to a model PLP‐dependent enzyme, serine hydroxymethyltransferase. PLP binding to YggS elicits a conformational/flexibility change in the protein structure that is detectable in solution but not in crystals. We serendipitously discovered that the K36A variant of YggS, affecting the lysine residue that binds PLP at the active site, is able to bind PLP covalently. This observation led us to recognize that a number of lysine residues, located at the entrance of the active site, can replace Lys36 in its PLP binding role. These lysines form a cluster of charged residues that affect protein stability and conformation, playing an important role in PLP binding and possibly in YggS function.
Identifying nutrient sources and sinks to the South Platte River and Cherry Creek, Denver, CO, during low‐flow conditions in 2019–2020
Authors: Battaglin William A. , Chapin Tanner W. 
Published: October 2022

AbstractElevated concentrations and loads of nutrients in the South Platte River and Cherry Creek in Denver, Colorado, may have adverse effects on those streams and downstream water bodies, including increased production of algae, eutrophication, and decreased recreational opportunities. This article describes streamflow and concentrations and loads of nutrients for the South Platte River and Cherry Creek in Denver based on data collected during two longitudinal Lagrangian sampling campaigns in low‐flow conditions in fall of 2019 and 2020. The results are used to assess sources and sinks of nutrients in the study area and help to establish baseline conditions against which future changes in nutrient concentrations and loads can be assessed. Discharges from Chatfield and Cherry Creek Reservoirs, storm drains, and most tributaries to the South Platte River, and Cherry Creek were generally small sources of streamflow and nutrient loads in both years. The Marcy Gulch, South Platte Water Renewal, and Robert W. Hite wastewater treatment plants were larger sources of streamflow and nutrient loads. The Burlington Ditch was a sink for streamflow and nutrient loads, diverting more than 95% of the South Platte River during the two sampling campaigns. Most other sinks were associated with decreases in streamflow between sampling sites. Golf courses were a potential source of nutrients for Cherry Creek but not for the South Platte River.
Low‐head dam removal increases functional diversity of stream fish assemblages
Authors: Jones Adam C. , Meiners Scott J. , Effert‐Fanta Eden , Thomas Trent , Smith Shannon C.F. , Colombo Robert E. 
Published: October 2022

AbstractDespite the growing number of dam removals, few have been studied to understand their impacts on stream fish communities. An even smaller proportion of dam removal studies focus on the impacts of low‐head dam removals, although they are the most common type of dam. Instead, the majority of removal studies focus on the impacts of larger dams. In this study, two previously impounded Illinois Rivers were monitored to assess the impacts of low‐head dam removal on the functional assemblage of stream fishes. Study sites were sampled each fall from 2012–2015 (pre‐dam removal) and 2018–2020 (post‐dam removal) in three locations: the tailrace, impoundment, and river channel. Fishes were aggregated into habitat and reproductive guilds, relating community changes to habitat, environmental metrics, and stream quality. Prior to removal, the slackwater guild was the most prevalent habitat guild throughout both rivers, while nest builders and benthic spawners were the most abundant reproductive guilds. During the two years following removal, fish assemblage throughout both rivers shifted to a more evenly distributed representation of habitat and reproductive guilds, while restoration of lotic habitat conditions increased, as surface water temperatures decreased and QHEI, IBI, and dissolved oxygen increased. This shift in environmental metrics and increase in overall stream quality increased, particularly in the formerly impounded reaches, indicate diminished habitat homogeneity, and a shift towards natural habitat diversity. This habitat diversification likely led to the restoration of a range of potential niches, thereby increasing the array of guild types inhabiting these rivers, while simultaneously preventing single‐guild dominance.
Small Fiber Neuropathy and Intractable Scalp Pruritus in Dermatomyositis Patients
Authors: Cirino Pablo Vitoriano , Hordinsky Maria , McAdams Brian , Romiti Ricardo 
Published: October 2022

Abstract

Background
Scalp pruritus is a common symptom in Dermatomyositis (DM) patients. There are indications that small nerve fibers neuropathy could be involved in this symptom, however the etiology of scalp pruritus is not fully understood.

Objectives
To assess epidermal nerve fiber (ENF) density of dermatomyositis patients with scalp pruritus by biopsy by confocal microscopy and immunohistochemistry with subsequent imaging analysis.

Methods
DM patients with severe scalp pruritus from the dermatology outpatient clinic were compared to healthy volunteers. Two 4-mm scalp skin biopsies were obtained above the right ear in the parietal region and below the occipital protuberance in the occipital region. Biopsy specimens were incubated with primary antibodies to protein gene product (PGP 9.5), calcitonin gene–related peptide (CGRP), substance P (SP) were used to visualize nerve fibers (ENF) and collagen IV was used to label the epidermal basement membrane. The number of ENFs per millimeter was counted and recorded as the mean of ± SD of counts in 16 images at two micrometer increments/sections, two from each of the samples. ENF densities were compared between groups and a multiple linear regression model was applied to associated factors with ENF density.

Results
Fifteen DM patients with severe scalp pruritus and 12 healthy volunteers were included in the study. The mean number of ENF/mm in occipital region of DM group was 16.0 ± 13.9 while the control group in the same region was 99.8 ± 33.1. In parietal region the number of ENF/mm of DM group was 18.0 ± 20.7 while in control group was 50.4 ± 17.4 (p &lt; 0.001).

Conclusion
DM patients with pruritus could have some impairment of small nerve fiber density that could explain their recalcitrant scalp pruritus.
A Strand Entangled Supramolecular PANI/PAA Hydrogel Enabled Ultra‐Stretchable Strain Sensor
Authors: Liu Dong , Zhou Honghao , Zhao Yuanyuan , Huyan Chenxi , Wang Zibi , Torun Hamdi , Guo Zhanhu , Dai Sheng , Xu Ben Bin , Chen Fei 
Published: October 2022

AbstractHydrogel electronics have attracted growing interest for emerging applications in personal healthcare management, human‐machine interaction, etc. Herein, a “doping then gelling” strategy to synthesize supramolecular PANI/PAA hydrogel with a specific strand entangled network is proposed, by doping the PANI with acrylic acid (AA) monomers to avoid PANI aggregation. The high‐density electrostatic interaction between PAA and PANI chains serves as a dynamic bond to initiate the strand entanglement, enabling PAA/PANI hydrogel with ultra‐stretchability (2830%), high breaking strength (120 kPa), and rapid self‐healing properties. Moreover, the PAA/PANI hydrogel‐based sensor with a high strain sensitivity (gauge factor = 12.63), a rapid responding time (222 ms), and a robust conductivity‐based sensing behavior under cyclic stretching is developed. A set of strain sensing applications to precisely monitor human movements is also demonstrated, indicating a promising application prospect as wearable devices.
Functional Zeolitic Imidazolate Framework for Robust l‐Deoxyribozyme‐Based Therapy
Authors: Tan Kaiyue , Zhang Qingqing , Wang Qing , Gong Xue , Yu Shanshan , Li Ruomeng , Liu Xiaoqing , Wang Fuan 
Published: October 2022

AbstractProgrammable chiral biocatalysis represents a promising therapeutic strategy for its high stereospecific control over various biotransformations (e.g., chiral Aβ isomerization) of living entities yet is rarely explored. With an extraordinary resistance to nuclease digestion, the non‐natural left‐handed deoxyribozyme (l‐DNAzyme) therapy is constrained by inefficient delivery/release and insufficient cofactors supply. Herein, an efficient adenosine triphosphate (ATP)‐stimulated disassembly of l‐histidine (l‐His)‐integrated ZIF‐8 (l‐His‐ZIF‐8) is reported for sustaining the l‐DNAzyme‐amplified photodynamic therapy. This self‐sufficient l‐therapeutic platform can intelligently release the l‐DNAzyme probe and simultaneously supply l‐His DNAzyme cofactors via endogenous ATP. Then, the intrinsic microRNA‐21 catalyzes the generation of robust l‐DNAzyme via the catalytic hybridization reaction for activating the photosensitizer with multiplied guaranteed therapeutic operation. This l‐therapeutic strategy opens up great prospects for more precise diagnosis and customized gene silencing‐based therapy.
Nonparametric precedence chart with repetitive sampling
Authors: Malela‐Majika Jean‐Claude 
Published: October 2022

AbstractIn most real‐world applications, such as production and manufacturing processes, the underlying process distribution does not always follow a normal distribution. In such cases, statistical process control literature recommends the use of nonparametric (or distribution‐free) control charts. This paper introduces a new distribution‐free precedence chart using repetitive sampling. The performance of the proposed chart is investigated in terms of the average run‐length (
) profile. The expressions of the in‐control process probability and
of the proposed chart are introduced using integral formulas. The out‐of‐control performance of the new chart is compared to that of the existing precedence charts with and without runs‐rules. A numerical example is provided using real‐life data to demonstrate the application and implementation of the new chart.
Den supplementation for black bears in coastal British Columbia
Authors: Davis Helen 
Published: October 2022

AbstractAmerican black bears (Ursus americanus) require suitable den sites that provide security and cover to successfully survive the winter denning period. On Vancouver Island, British Columbia, Canada, black bears prefer to use cavities associated with large‐diameter hollow trees or structures derived from trees (i.e., cavities in or under logs, root boles and stumps) as den sites. Extensive harvesting of coastal forests has reduced the availability of natural den structures such that their supply may affect population sustainability. I attempted to develop new methods to address the declining supply of denning opportunities by creating and testing new den structures constructed in trees, stumps and from plastic. Between 2014–2021, I created or deployed and monitored 17 potential den structures in 2 study areas that were believed to have low den supply. I documented up to 51 visits by bears at each structure; every one of the video‐monitored structures was investigated at least 5 times. None of the plastic artificial den structures were used by bears, but an enhanced natural structure was used as a den over 4 consecutive winters. My work indicates that bears will find and investigate all natural or artificial denning structures in their environment, but artificial structures do not appear to be a viable method to mitigate losses of dens caused by forest harvesting.
The Role of Heritage in Post-War Reconciliation: Going Beyond World Heritage Sites
Authors: Hisari Lorika , Barrett-Casey Kristen , Fouseki Kalliopi 
Published: October 2022

AbstractIt is widely acknowledged that reconciliation and sustainable development are processes that necessitate involvement from local, national and international actors. However, with the attention of international actors overwhelmingly focused on World Heritage sites, this chapter seeks to examine the potential consequences of the disparity in treatment between those sites on the World Heritage List and those that are not but are still significant for their local communities. Kosovo and Iraq are the two cases we use to explore the role, use and treatment of heritage in post-war recovery and reconciliation and how this is affected by World Heritage status. Through an examination of heritage as a political process, we can approach a more in-depth understanding of how heritage shapes and reshapes the politics of post-war memory, inter-community relations, and the extent to which the international community uses World Heritage in these communities to mandate their own politics of remembrance. We argue that heritage can have a “pacifying” role and contribute to peacebuilding, but this will need active, transformative actions from UNESCO which go beyond the Convention and, if possible, beyond politically influenced decision-making. This chapter seeks to fill a gap in the literature of how the local, national and international interact in the post-war environment, as well as the true impact of potential inequalities created by World Heritage.
Shameful Traces and Image-Based Sexual Abuse: The Case of Tiziana Cantone
Authors: Romania Vincenzo 
Published: October 2022

AbstractIn this chapter, I reflect on the relationship between shame and digital traces in cases of image-based sexual abuse (IBSA) (I am thankful to Giovanni Zampieri, Dario Lucchesi and Massimo Cerulo for their invaluable help in writing and revising this chapter.). I will introduce the concept of shameful trace to describe records of diverse nature that can be used by a group of people participating in an effort to stigmatise an appearance, a conduct, an attitude or any other cause of social disapproval. Such a record is an object of shame only in a latent form. For it to become a shameful trace, it is necessary that it be shared and focussed on particular situations of moral condemnation.This is neither a purely theoretical nor a purely empirical article. Rather, I first consider a case study of moral violence against a young Italian woman, Tiziana Cantone, who committed suicide in 2016 after the widespread non-consensual dissemination of intimate images. Further, I propose a theoretical understanding of the diffusion of shameful traces as a process of concerted social action including five elements: first, the ontology of the trace; second, the actors involved in its production and diffusion; third, the temporal and spatial coordinates of the shame diffusion and the technical or social means employed in it; and finally (fourth and fifth), the cultural and normative frameworks. Finally, I investigate how social bonds and sociotechnical and normative regulations favour the diffusion of shame in cases of IBSA.
The Personal Repertoire and Its Materiality: Resources, Means and Modalities of Languaging
Authors: Dufva Hannele 
Published: October 2022

AbstractThe chapter is a theoretical discussion of the concept ofpersonal repertoireand its application in the context of applied linguistics, particularly in the study of language learning and development. It questions conceptualisations that understand language learning as acquisition of abstract, decontextual and disembodied language knowledge and argues that learners’ know-how is not based on any kind of ‘mental grammar’, but on a personal repertoire of different multimodal semiotic resources. Bringing together ‘old’ and ‘new’ arguments for materialism, personal repertoires are examined focussing on how embodied agentive activity is intertwined with the socially structured environments and their specific material features, tools and artefacts. The repertoire, or the know-how that emerges, is not, strictly speaking, ‘language’, but rather, a meshwork of ‘skilled linguistic action’ in the analysis of which embodiment and materiality are highly significant considerations. The viewpoint transcends the alleged gap between social and cognitive orientations of language learning research and discusses learning and use of language from an ecological point of view as ‘languaging’.
Isospin-breaking effects in the two-pion contribution to hadronic vacuum polarization
Authors: Colangelo Gilberto , Hoferichter Martin , Kubis Bastian , Stoffer Peter 
Published: October 2022

Abstract
Isospin-breaking (IB) effects in the two-pion contribution to hadronic vacuum polarization (HVP) can be resonantly enhanced, if related to the interference of the ρ(770) and ω(782) resonances. This particular IB contribution to the pion vector form factor and thus the line shape in e+e−→ π+π− can be described by the residue at the ω pole — the ρ-ω mixing parameter ϵω. Here, we argue that while in general analyticity requires this parameter to be real, the radiative channels π0γ, ππγ, ηγ can induce a small phase, whose size we estimate as δϵ = 3.5(1.0)° by using a narrow-width approximation for the intermediate-state vector mesons. We then perform fits to the e+e−→ π+π− data base and study the consequences for the two-pion HVP contribution to the anomalous magnetic moment of the muon, its IB part due to ρ-ω mixing, and the mass of the ω resonance. We find that the global fit does prefer a non-vanishing value of δϵ = 4.5(1.2)°, close to the narrow-resonance expectation, but with a large spread among the data sets, indicating systematic differences in the ρ-ω region.
Master integrals for $$ \mathcal{O} $$(ααs) corrections to H → ZZ*
Authors: Chaubey Ekta , Kaur Mandeep , Shivaji Ambresh 
Published: October 2022

Abstract
We present analytic results for all the Feynman integrals relevant for $$ \mathcal{O} $$
O
(ααs) virtual corrections to H → ZZ* decay. We use the method of differential equations to solve the master integrals while keeping the full dependence on the masses of all the particles, including those propagating in the loop. Due to the presence of four mass scales, we encounter multiple square roots. We argue that all the occurring square roots can not be rationalized at the same time as a simultaneous rationalization brings us to integrals over CY3 manifolds. Hence we rationalize only three square roots simultaneously and construct suitable ansätze to obtain dlog-forms containing the square roots after obtaining an epsilon-factorised form for the differential equations in D = 4 − 2ϵ dimensions. We present the alphabet and the analytic form of all the boundary constants that appear in the solutions of the differential equations. The results for master integrals are expressed in terms of Chen’s iterated integrals with dlog one-forms.