bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Correlation between the Level of Health-Improving and Recreational Physical Activity and Family Well-Being
Authors: Andrieieva Olena , Maltsev Dmytro , Kashuba Vitalii , Grygus Igor , Zaharina Evgeniia , Vindyk Andriy , Skalski Dariusz , Hutsman Serhii 
Published: December 2022

Study purpose. The purpose of the study was to assess the correlation between the level of health-improving and recreational physical activity and family well-being.
Materials and methods. Theoretical analysis of data from special scientific and methodological literature, generalization, systematization, sociological methods, and mathematical statistics. A research among parents was conducted using online surveying through completing an online questionnaire created with Google Forms. The study involved 106 married couples. The average age of the respondents was 35.1±4.2 years. The vast majority of the studied families (95.1%) had up to two children (preschool and school age).
Results. The respondents were divided into two clusters according to their level of motor activity. Cluster 1 included families with a low level of physical activity, and cluster 2 included those with an average level of physical activity.Depending on the level of physical activity, statistically significant (p < 0.05) differences were found between the families in terms of the following parameters: motivations for engaging in active leisure, amount of leisure time, level of knowledge and skills in organizing active leisure, reasons preventing participation in active leisure, etc. The families differed significantly (p < 0.05) in 23 categorical parameters. It was found that the families with different levels of physical activity did not differ in their desire to engage in winter recreational activities. Reasons preventing participation in health-enhancing and recreational physical activity programs were identified. A comparative analysis of the current state of family well-being revealed statistically significant (p < 0.05) differences in all studied parameters between the families with different levels of physical activity, i.e. the families with a proper level of physical activity had higher scores of satisfaction, well-being, and quality of life. Low indicators of family well-being indicated the rationale for such families to engage in active recreation and increase their level of health-enhancing and recreational physical activity.
Conclusions. A relationship was identified between the level of health-enhancing and recreational physical activity and indicators of satisfaction, family well-being, and quality of life.
Verwaltungsschalen-basierte Orchestrierung von Co-Simulationen
Authors: Schoch Nicolai , Schlake Jan-Christoph , Grüner Sten , Heuschkel Jens , Karaagac Abdulkadir 
Published: December 2022

Simulation ist eine Schlüsseltechnologie für mehrere Anwendungsfälle der Industrie 4.0. Die Simulation komplexer industrieller Systeme mit mehreren Subsystemen ist jedoch kompliziert und erfordert die Zusammenarbeit und Orchestrierung getrennter Simulationsmodelle. Daher wird in diesem Artikel eine Lösung vorgeschlagen, die die Interoperabilität und Orchestrierung von Simulationen mit Hilfe von semantischen Beschreibungen auf Basis der Asset Administration Shell (AAS) ermöglicht. Der vorgeschlagene Ansatz wird auch anhand eines realen Szenarios verifiziert, das die Dimensionierung von Antrieben in einem Antriebsstrang bei gleichzeitiger Steuerung der ganzheitlichen Simulation ermöglicht.
Assessment of distress in patients visiting pain and palliative out patient department of a tertiary care hospital in Assam
Authors: Borkotoky Priyakhi , Deka Arun , Dakua Dipankar , Das Shantana 
Published: December 2022

Background: Distress is a multifactorial entity seen in patients battling with cancer. It is under-reported and under-managed posing a hurdle in providing holistic patient care. It has a negative effect on the treatment and treatment adherence in cancer patients.Methods: A cross- sectional study was done in the pain and palliative outpatient clinic of State Cancer Institute, Guwahati, Assam. About 250 patients were screened for distress using a questionnaire consisting of national comprehensive cancer network (NCCN) distress thermometer (DT) and problem list over a span of 4 months after obtaining due consent. They were asked to mark their level of distress and the contributing factors for distress as enlisted in the NCCN DT problem list. Chi square test and Mann Whitney test were used to analyze statistical significance.Results: The distress levels were assessed based on the effects of the disease, treatment and other demographic variables and possible causes contributing to distress were determined. It was noted that out of 250 patients screened (n=250), 88 (35.2%) reported a distress score of 4 while 79 (31.6%) reported with a score of 6. Nature of the disease and current treatment received by the patient was significantly associated with distress while age, marital status and sex was not. Amongst physical, emotional and practical problems leading to distress, pain (45.2%), worry (49.2%) and transportation issues (45.1%) respectively were significantly reported as primary causes of distress.Conclusions: NCCN DT in an effective tool for assessment of distress in cancer patients of Assam. It helps in identification of probable causes of distress which aids in holistic patient care.
Is the AURKB Gene Involved in Aml Cell Proliferation Since It is Targeted by miR-34a-5p and let-7b-5p?
Authors: SUER Ilknur , KAYA Murat 
Published: December 2022

Objective: The production of normal blood cells in the bone marrow is interrupted in AML, which is characterized by the proliferation and accumulation of leukemic blasts. Therefore, patients experience anemia and thrombocytopenia. When gene expression of Aurora kinases, which is reported to be highly expressed in AML, decreases, it may be possible to alleviate the clinical findings in AML. In this study, it was aimed to examine the relationship of AURKB with important miRNAs that have the potential to regulate gene expression.
Method: HL60 and NB4 cells were transfected with important tumor suppressor miRNAs miR-34a-5p and let-7b-5p mimics. Then, its effects on proliferation were examined with WST-8 technique and its effects on AURKB gene expression were examined with qRT-PCR.
Results: It was determined that these miRNAs negatively regulated proliferation in both AML cell lines and downregulated the expression level of the Aurora kinase B (AURKB) gene in the miRNA transfected group compared to the control group.
Conclusion: In conclusion, it was determined that miR-34a-5p and let-7b-5p could regulate AURKB expression in AML cells. Therefore, it was thought that these miRNAs may have an important potential as a therapeutic biomarker in preventing excessive cell division and poor prognosis in AML.
The Mal’dzhangarka Carbonatite Massif (Anabar Shield): The Age of Magmatism and Mineralization (U–Pb and Re–Os Isotope Systems)
Authors: Molchanov A.V. , Guzev V.E. , Lepekhina E.N. , Krymsky R.Sh. , Antonov A.V. , Belyatsky B.V. , Khorokhorina E.I. 
Published: December 2022

Abstract
—We present the first results of a comprehensive isotope-geochemical study of dolomitic carbonatites of the Mal’dzhangarka massif located in the southeast of the Billyakh melange zone (southeastern periphery of the Anabar Shield). Zircon grains separated from core samples from a depth of 6–30 m have a three-phase structure. All of them were trapped from the host metamorphic rocks and mark the age of the main stage of high-gradient metamorphism in the region, 2027 ± 9 Ma. Pyrochlore containing 38–705 ppm U and 5–21 ppm radiogenic Pb, with weak metamictization of the crystal lattice and an undisturbed U–Pb system, made it possible to estimate the concordant age of rare-metal mineralization in the massif, 167 ± 4 Ma, which is probably close to the crystallization age of the host carbonatites. The estimated age corresponds to one of the stages of kimberlite–carbonatite magmatism on the eastern slope of the Anabar dome. The Re–Os isotope system of pyrite from superposed late carbonate–sulfide veinlets in the carbonatites testifies to a close (within the error of determination) age, 179 ± 14 Ma, and a low initial Os isotope ratio, which indicates the contribution of mantle material to the formation of this isotope system.
Mathematical Analysis and Performance Evaluation of the Cell-Free mMIMO Networks based on Cognitive IRSs
Authors: Shalaby Mohamed Saeid , Lamie Mina Wagih , Shokair Mona Mohamed Sabry 
Published: December 2022

Abstract

One of the powerful tools towards the 5G networks and beyond is the application of Cell-Free mMIMO networks. These networks can provide high levels of spectral efficiency SE and energy efficiency EE. In this paper, there are two motivations. The first motivation is application of cognitive radio theory that can minimize the mutual interference. The second motivation is application of Intelligent Reflecting Surfaces IRSs in cell-Free mMIMO networks in order to improve the SE and EE performance even for shadowed and indoor users. In this paper, the performance of the Cell-Free mMIMO based on cognitive IRSs is mathematically analyzed and simulated. The SE and EE are given in a closed form formula. It can be concluded that, the Cell-Free mMIMO network based on cognitive IRSs has a high SE and EE performance.
Predictors of participant retention in a community-based HIV prevention cohort: perspectives from the HPTN 071 (PopART) study
Authors: Bell-Mandla Nomtha , Sloot Rosa , WIlson Ethan , Sharma Deeksha , Floyd Sian , Moore Ayana , Piwowar-Manning Estelle , Makola Nozizwe , Bwalya Justin , Simwinga Musonda , Nkonki Lungiswa , Schaap Ab , Donnell Deborah , Ayles Helen , Fidler Sarah , Hayes Richard , Bock Peter Alwin 
Published: December 2022

Abstract
Introduction
In 2020, there were 37.7 million people living with HIV (PLHIV) globally, of which 20,6 million (55%) were living in Eastern and Southern Africa. Longitudinal studies, inclusive of community randomized trial (CRTs), provide critical evidence to guide a broad range of health care interventions, including HIV prevention. In this study, we have used an individual-level cohort study design to evaluate the association between sex and other baseline characteristics and participant retention in HPTN 071 (PopART) in Zambia and South Africa.
Methods
HPTN 071 (PopART) was a community randomized trial (CRT) conducted from 2013-2018, in 21 communities. The PopART primary outcome was measured in a randomly selected population cohort (PC), followed up over 3 to 4 years at annual rounds. PC retention was defined as completion of an annual follow up survey. Baseline characteristics were described by study arm and Poisson regression analyses used to measure the association between baseline factors and retention. In addition, we present a description of researcher-documented reasons for study termination by study participants in the population cohort (Table 3).
Results
Overall, 48301 individuals aged 18-44 years were enrolled, of whom 15 225 (40%) were aged 18-24 years. Most participants were women (27 139, 71%). Of the 38 474 participants enrolled at during the first round of the trial (PC0), 73. completed at least one follow up visit. Retention was lower in men (RR: 0.895; 95% CI: 0.875, 0.914) and higher amongst older participants (RR: 1.220; 95% CI 1.188, 1.253) when comparing age>35 to 18-24 years. Retention was also higher amongst individuals with high socio-economic status (SES) when compared to medium SES (RR 1.161; 95% CI 1.135, 1.188) and low SES (RR 1.117; 95% CI 1.093, 1.142) . The most common reasons for study termination were study refusal (23%) and relocation outside the CRT catchment area (66%).
Conclusion
Despite challenges, satisfactory retention outcomes were achieved in PopART with limited variability across study arms. In keeping with other studies, age, sex and SES were associated with lower levels of retention, relocation outside of catchment area was the most common reason for non- retention in this CRT.
Non-invasive Cuff Free Blood Pressure and Heart Rate Measurement From Photoplethysmography (Ppg) Signal Using Machine Learning
Authors: Chakraborty Parnasree , C Tharini 
Published: December 2022

Abstract

Measuring and monitoring Blood Pressure for cardiovascular patients is critical and essential too. A variation in heart rate is very important for a patient’s physiological condition analysis. But using cuff every time for measuring Blood Pressure, passing electrical signal to monitor Heart rate may irritate the patient. This idea provides cuff less measurement of Blood Pressure and Heart rate measurement using Photoplethysmography only. Arterial Blood Pressure and Photoplethysmogram along with Electrocardiogram is the most popular methods of measuring Cardio Vascular Status these days. Mostly both ABP and PPG together perform operations like monitoring Blood pressure with high efficiency and ECG for Heart rate. Measuring Heart rate from ECG and Blood Pressure from ABP may cause discomfort to the subject. So, we implement only PPG based system to monitor Both Blood Pressure and Heart rate. Now a days, Internet of Things, Cloud, Artificial Intelligence, and Machine Learning are taking their place everywhere to reduce the man power and ease the computations in automating this world. We detect the PPG signal and transfer the data to cloud in order to apply the Machine Learning algorithm to measure the Blood pressure and Heart rate. This paper gives about the various Machine learning ideas of measuring Blood Pressure along with Heart rate. We used Support Vector Regression, Random Forest, Decision Tree, Adaboost and Adaboost hyper tuning algorithms of machine learning for prediction of Blood Pressure and resulted with high accuracy in Decision Tree and Adaboost algorithms among all the five algorithms tried.
The Impact of Nurse Navigation on Timeliness to Treatment for Benign High-Risk Breast Pathology
Authors: Barker Catherine Shirer , Chung Catherine W. , Mukherjee Rupak , Siegel Julie B. , Cole David J. , Lockett Mark A. , Klauber-DeMore Nancy , Abbott Andrea M. 
Published: December 2022

Abstract
Purpose

High-risk breast pathology is a breast cancer risk factor for which timely treatment is crucial. Nurse navigation programs have been implemented to minimize delays in patient care. This study evaluated nurse navigation in terms of timeliness to surgery for patients with high-risk breast pathology.

Methods

This was a single-institution, retrospective review of patients with identified high-risk breast pathology undergoing lumpectomy between January 2017 and June 2019. Patients were stratified into cohorts based on periods with and without nurse navigation. Preoperative and postoperative time to care as well as demographic and tumor characteristics were compared using univariate and multivariate analysis.

Results

100 patients had assigned nurse navigators and 29 patients did not. Nurse navigation was associated with reduced time from referral to date of surgery (DOS) by 16.9 days (p=0.003). Patients >75 years had a shorter time to first appointment (p=0.03), and patients with Medicare insurance had a reduced time from referral to DOS (p=0.005). 20% of all patients were upstaged to cancer on final surgical pathology.

Conclusion

Nurse navigation was significantly associated with decreased time to care for patients with high-risk breast pathology undergoing lumpectomy. We recommend nurse navigation programs as part of a comprehensive approach for patients with high-risk breast pathology.
Behavioral abnormalities in C57BL/6 mice with chronic ulcerative colitis induced by DSS
Authors: Zhou Yuxin , Ji Gang , Yang Xiaoyi , Chen Zhenhua , Zhou Liangliang 
Published: December 2022

Abstract
Background: Clinical epidemiological studies have found that some patients with ulcerative colitis (UC) are prone to mental disorders. DSS-induced acute and chronic UC models are often used to evaluate the efficacy of anti-UC drugs. However, whether DSS has an effect on mouse behavior has not been reported.
Methods: Acute and chronic UC models were induced by 3% DSS and 1.5% DSS, respectively. The bloody stool, the changes in the colon length, and histopathological changes in the colon were used to evaluate the success of the animal model. The behavior of mice was evaluated by open field experiment, tail suspension experiment and Sucrose preference test.
Results: The weight of mice in 3% DSS group decreased significantly, the DAI score increased significantly, the colon length of mice was significantly shortened, and the structure of colonic crypts was abnormal, which showed inflammatory cell infiltration and shrinkage of crypts. Compared with the control group, the immobility time of 3%DSS group mice in the tail suspension test and forced swimming test had no effect, the number of running and grooming times was significantly reduced, and there was no significant difference in the number of standing times. No abnormality was observed in HE staining of the hippocampus. However, in 1.5% DSS-induced chronic UC model, behavioral and hippocampal abnormalities were observed not only UC symptoms.
Conclusions: Acute UC induced by 3% DSS had little effect on mouse behavior, while chronic UC induced by 1.5% DSS had a significant effect on mouse behavior.
Exploring the Professional Identity of Advanced Clinical Practitioners: Constructivist ethnographic qualitative research study
Authors: Amine Anouar , Mannion Christopher 
Published: December 2022

Abstract
Background: The Advanced Clinical Practitioner (ACP) is a healthcare professional who has undertaken additional years of Master's level training, acquired new skills and capabilities and developed as an autonomous practitioner.
Purpose: Whilst several studies have appraised and analysed this professional role, there are limited empirical studies that have explored professional identity formation within this group. This paper explores this evolution.
Method: Through a constructivist ethnographic approach, we conducted semi-structured interviews with seven qualified ACPs within a secondary care setting. We identified key issues regarding professional identity formation.
Results: Our research highlights the lack of role recognition which acts as a barrier to ACP professional identity formation and further development.
Conclusion: We suggest that a clearer definition of the professional capabilities of ACP is developed to highlight and promote this professional group especially as they now work within an increasingly diverse range of healthcare settings. Specifically, this paper suggests:
- To integrate educational strategies, peripheral participation and vocational studies within the ACP academic curriculum to explicitly discuss professional identity and expand related knowledge to support trainee ACPs to reconcile with this pivoting topic from the beginning of their training.
- To support the ACP role recognition to the medical community at large. This identifies other medical colleagues, Allied healthcare practitioners and patients using healthcare services.
- To enhance different methods of recognition between ACPs who are qualified and those who are in training, specifically, specifying at which stage of their training they are to aid professional identity justification and correct representation
- To build robust mentorship able to encourage, address and improve personal development.
Chromosome-level assembly of the Rangifer tarandus genome and validation of cervid and bovid evolution insights
Authors: Poisson William , Prunier Julien , Carrier Alexandra , Gilbert Isabelle , Mastromonaco Gabriela , Albert Vicky , Taillon Joëlle , Bourret Vincent , Droit Arnaud , Côté Steeve D. , Robert Claude 
Published: December 2022

Abstract
Background:Genome assembly into chromosomes facilitates several analyses including cytogenetics, genomics and phylogenetics. Despite rapid development in bioinformatics, however, assembly beyond scaffolds remains challenging, especially in species without closely related well-assembled and available reference genomes. So far, four draft genomes of Rangifer tarandus (caribou or reindeer, a circumpolar distributed cervid species) have been published, but none with chromosome-level assembly. This emblematic northern species is of high interest in ecological studies and conservation since most populations are declining.
Results:We have designed specific probes based on Oligopaint FISH technology to upgrade the latest published reindeer and caribou chromosome-level genomes. Using this oligonucleotide-based method, we found six mis-assembled scaffolds and physically mapped 68 of the largest scaffolds representing 78% of the most recent R. tarandus genome assembly. Combining physical mapping and comparative genomics, it was possible to document chromosomal evolution among Cervidaeand closely related bovids.
Conclusions:Our results provide validation for the current chromosome-level genome assembly as well as resources to use chromosome banding in studies of Rangifer tarandus.
The impact of environmental regulation on renewable energy development in China from the perspective of spatial effects
Authors: Yang DongXiao , Tan Lin , Wu QianGe , Tang AnYan , Li ZhengYong 
Published: December 2022

Abstract
From a spatial perspective, this paper constructs a spatial Durbin model based on the adjacent weight matrix to analyze the impact of environmental regulation on the development of renewable energy in 30 provinces (autonomous regions and municipalities directly under the Central Government) in China from 2007 to 2020. The results show that: 1) Both environmental regulation and renewable energy development have positive spatial autocorrelation, and form relatively similar spatial agglomeration areas, specifically showing the characteristics of "high-high" agglomeration in resource-rich areas, and "low-low" agglomeration in resource-scarce areas. 2) In general, the intensity of environmental regulation in this province has a significant role in promoting the development of renewable energy and has a significant spatial spillover effect on the development of renewable energy in neighboring provinces due to the influence of geographical distance, economic level, infrastructure construction and other factors. 3) The moderating effect results show that infrastructure construction and electricity demand play an inverse moderating role between environmental regulation and renewable energy development. 4) From the perspective of different regions, the impact of environmental regulation on the development of renewable energy is heterogeneous. Based on the research conclusions, this paper finally puts forward some policy suggestions, such as strengthening the environmental assessment and incentive system, strengthening the cooperation between local governments and rationally optimizing the energy structure.
Effect of metal cations on colloids-Microcystin-LR interaction
Authors: Hu Xin , Zheng Fengmin , Li Jing , Wang Juan , Yin Li , Shi Kaipian , Huang Heyong , Li Shiyin 
Published: December 2022

Abstract
Colloidal particles, mixture with continuous molecular weight distribution and multiple organic components, is widespread in lake and have significant impact on the retention, migration, transportation, and fate of contaminants in lake ecosystems. Here we extract sedimentary colloids from algal growth dominant area (AD) in Taihu Lake and further separated into four different particle size ranges by cross-flow ultra-filtration (CFUF). The interaction mechanism between colloids and Microcystin-LR (MC-LR) was investigated under different cation conditions by dialysis equilibrium experiment method. Adsorption kinetics research shows the adsorption of MC-LR by colloids follows second-order kinetics and can be simulated by Freundlich isotherms. The effects of different cations on colloids-MC-LR interaction shows the addition of Mg(II) decreased colloids-MC-LR interaction, while Cu(II) increased colloids-MC-LR binding. MC-LR also increased Cu(II) binding to colloids, while MC-LR decreased Mg(II) binding. Therefore, different effect of cations to colloids-MC-LR interaction was proposed.