bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation and Implementation of KIDs List Recommendations in a University Health System
Authors: Anderson Victoria H. , Anderson Jordan , Durham Sarah , Collard Erin 
Published: September 2022

OBJECTIVEThe study aims to identify the rate of inappropriate prescribing per the Key Potentially Inappropriate Drugs in Pediatrics (KIDs) List versus total prescribing in patients at University of Missouri Health Care hospitals.METHODSThis retrospective study evaluated orders for patients treated at University of Missouri Health Care inpatient units or emergency departments with a KIDs List medication between September 1, 2019, and September 1, 2020, or a reported adverse event to one of these medications between September 1, 2015, and September 1, 2020. Patients were excluded if the patient safety report was related to a medication error rather than an adverse event. Safety measures assessed included age and weight filtering, dose-range checking, clinical decision support, and override availability.RESULTSThere were 39 inappropriate orders and 4 possible adverse events identified. A total of 8 of 33 medications (24%) had age and weight filtering in place for at least 1 order sentence, 1 of 38 (2.6%) had dose-range checking, no medications had an active clinical decision support alert, and 33 of 38 (87%) had availability on automated dispensing cabinet override.CONCLUSIONSUse of KIDs List medications is appropriately low, but low levels of safety measure implementation leave pediatric patients vulnerable.
Comparative mitogenomic analyses and gene rearrangements reject the alleged polyphyly of a bivalve genus
Authors: Cunha Regina L. , Nicastro Katy R. , Zardi Gerardo I. , Madeira Celine , McQuaid Christopher D. , Cox Cymon J. , Castilho Rita 
Published: September 2022

Background
The order and orientation of genes encoded by animal mitogenomes are typically conserved, although there is increasing evidence of multiple rearrangements among mollusks. The mitogenome from a Brazilian brown mussel (hereafter named B1) classified as Perna perna Linnaeus, 1758 and assembled from Illumina short-length reads revealed an unusual gene order very different from other congeneric species. Previous mitogenomic analyses based on the Brazilian specimen and other Mytilidae suggested the polyphyly of the genus Perna.

Methods
To confirm the proposed gene rearrangements, we sequenced a second Brazilian P. perna specimen using the “primer-walking” method and performed the assembly using as reference Perna canaliculus. This time-consuming sequencing method is highly effective when assessing gene order because it relies on sequentially-determined, overlapping fragments. We also sequenced the mitogenomes of eastern and southwestern South African P. perna lineages to analyze the existence of putative intraspecific gene order changes as the two lineages show overlapping distributions but do not exhibit a sister relationship.

Results
The three P. perna mitogenomes sequenced in this study exhibit the same gene order as the reference. CREx, a software that heuristically determines rearrangement scenarios, identified numerous gene order changes between B1 and our P. perna mitogenomes, rejecting the previously proposed gene order for the species. Our results validate the monophyly of the genus Perna and indicate a misidentification of B1.
Comparative Glycemic Control in Adult Patients with Type 2 Diabetes on Herbal and Conventional Glucose-Lowering Agents in Nairobi County, Kenya
Authors: Karara Monicah W. , Okalebo Faith Apolot , Ndirangu Peter K. , Opanga Sylvia A. 
Published: September 2022

Background: Some diabetic patients seek care exclusively from traditional herbal practitioners. It is not known if the care provided by herbalists is effective in maintaining optimal glycemic control.
Aim: To compare glycemic control in adult patients with type 2 diabetes on treatment with conventional medicines against those on herbal glucose-lowering therapies.
Study Design: Descriptive cross-sectional study.
Place and Duration of Study: Patients on conventional treatment were recruited from the Endocrinology and Diabetes Outpatient Centre at Kenyatta National Hospital. The comparative group was enrolled from the New Life Herbal Clinic. The study was carried out between March 2019 and December 2021.
Methodology: We recruited 80 patients on treatment with conventional antidiabetic therapies at Kenyatta National Hospital (KNH) and 37 patients on herbal therapies at New Life Herbal Clinic (NLHC). A structured questionnaire was used to collect sociodemographic and clinical data. Consecutive sampling was used to recruit the study participants. Glycated hemoglobin (HbA1C) levels were measured at the time of the patient visit.
Patients with HbA1c levels <7% were considered to have achieved adequate glycemic control. Descriptive and inferential data analysis was performed on all the variables and compared across the two study arms. Regression analysis was performed to identify variables associated with glycemic control for each treatment group. Data were entered into and analyzed using SPSS software version 26 (SPSS Inc, Chicago, USA). P-values <0.05 were considered to be statistically significant.
Results: Patients on conventional antidiabetic medications had significantly lower mean HbA1c levels (7.40+1.92) % compared to (8.34+1.97) % in the herbal treatment arm (P=0.016). Significant differences in mean HbA1c % were reported in patients on a combination of 5-6 herbs (7.06 +1.54) % compared to those on 3-4 herbs (8.63+1.91) % (P= 0.045). Significant predictors of adequate glycemic control (HbA1c< 7%) were having a past HbA1c check ( (aOR= 3.098 (95% C.I=1.258-7.631) P=.014), adherence to medications ( (aOR= 6.055 (95% C.I=1.623-22.593) P= .007), treatment with Launaea cornuta ( (aOR= 7.143 (95% C.I=1.462-34.893) P= 0.015) and being married (aOR=2.870 (95% C.I=1.054-7.818) P=0.039).
Conclusion: Patients on treatment with conventional agents reported better glycemic control compared to those on herbal therapies. Regular monitoring of HbA1c, adherence to medications, having a spouse and treatment with Launaea cornuta may enhance blood glucose control in patients with type 2 diabetes.
Translation Strategies in Indonesian Subtitle and Dubbing of The Greatest Showman
Authors: Jane Yovita , Rini Julia Eka 
Published: September 2022

Several studies have compared translation strategies to analyze subtitles and dubbing in movies, but few have compared the differences between the two mediums. This study compared the translation strategies used in movie subtitles and dubbing. Baker's (2018) translation strategies are used to analyze the Disney+ subtitle and dubbing of The Greatest Showman. Baker (2018) identifies 12 translation strategies used in the subtitle and dubbing: general word, more neutral/less expressive word, cultural substitution, loan word and explanation, paraphrase using related words, paraphrase using unrelated words, omission, idiom of similar meaning and form, idiom of similar meaning but dissimilar form, paraphrase, omission of a play on idiom, omission of entire idiom. One strategy, borrowing the source language idiom, employed by the dubbing is not found in the subtitle and one strategy, illustration, is not used in both. The fact that using the same strategy does not produce the same translation result shows that there are infinite interpretations. Keywords: translation strategies, subtitle, dubbing
Simultatem Chronicles: The Fear of Imagination and Discrimination and Their Impacts on Preteenagers
Authors: Nurtanto Levana Vivian , Limanta Liem Satya 
Published: September 2022

This short story series is a coming-of-age and dystopian series that focuses on the impacts of the fear of imagination and discrimination on preteens and how they cope with it. This fear is shown through a virus named imaginatio virus, a special virus that attacks the main characters to induce imagination. The government made imagination-prevention and discrimination rules to get rid of the virus completely. We explore how the fear of imagination and discrimination affect the four main characters in each story. We apply the theory of social influence, discrimination, and coping mechanisms to show how Dylan, Elias, Bryna, and Corina deal with the effects of discrimination. In our creative work, we show that the four main characters succeed in being confident by focusing on the strength in themselves, finding help in trusted people, and not dwelling in the problem. Keywords: imagination, short stories, discrimination, dystopian, coming-of-age
Treatment‐planning approaches to intensity modulated proton therapy and the impact on dose‐weighted linear energy transfer
Authors: Faught Austin M. , Wilson Lydia J. , Gargone Melissa , Pirlepesov Fakhriddin , Moskvin Vadim P. , Hua Chia‐Ho 
Published: September 2022

AbstractPurposeWe quantified the effect of various forward‐based treatment‐planning strategies in proton therapy on dose‐weighted linear energy transfer (LETd). By maintaining the dosimetric quality at a clinically acceptable level, we aimed to evaluate the differences in LETd among various treatment‐planning approaches and their practicality in minimizing biologic uncertainties associated with LETd.MethodEight treatment‐planning strategies that are achievable in commercial treatment‐planning systems were applied on a cylindrical water phantom and four pediatric brain tumor cases. Each planning strategy was compared to either an opposed lateral plan (phantom study) or original clinical plan (patient study). Deviations in mean and maximum LETd from clinically acceptable dose distributions were compared.ResultsIn the phantom study, using a range shifter and altering the robust scenarios during optimization had the largest effect on the mean clinical target volume LETd, which was reduced from 4.5 to 3.9 keV/μm in both cases. Variations in the intersection angle between beams had the largest effect on LETd in a ring defined 3 to 5 mm outside the target. When beam intersection angles were reduced from opposed laterals (180°) to 120°, 90°, and 60°, corresponding maximum LETd increased from 7.9 to 8.9, 10.9, and 12.2 keV/μm, respectively. A clear trend in mean and maximum LETd variations in the clinical cases could not be established, though spatial distribution of LETd suggested a strong dependence on patient anatomy and treatment geometry.ConclusionChanges in LETd from treatment‐plan setup follow intuitive trends in a controlled phantom experiment. Anatomical and other patient‐specific considerations, however, can preclude generalizable strategies in clinical cases. For pediatric cranial radiation therapy, we recommend using opposed lateral treatment fields to treat midline targets.
Low‐Temperature Melt Processing Monolithic Integration of Organic Manganese (II) Bromide Wafers with Pixelated Substrate for High Sensitivity X‐Ray Imaging
Authors: Li Hengxin , Lei Yutian , Peng Guoqiang , Wang Qian , Li ZhenHua , Wang Haoxu , Wang Gang , Jin Zhiwen 
Published: September 2022

AbstractEnvironmentally‐friendly metal halides have become emerging candidates for X‐ray imaging applications. However, it remains challenging to obtain noise and ion migration suppressed crystal structures. More seriously, integration with mature circuits in an easy‐to‐implement manner is a huge obstacle to commercialization. Here, a 0D structure‐based benzyltrimethylammonium manganese bromide (BTA2MnBr4, BTA: C10H16N) is reported. Further studies point out that such structure exhibits obvious quantum confinement effects, providing large bandgap (3.20 eV) and exciton activation energy (≈115 meV) with decreasing thermal noise, and large activation energy for ionic transport (≈0.37 eV) with limited ion migration. Then, the BTA2MnBr4 wafer is fabricated via solvent‐free, scalable, and low‐temperature (175 °C) melt processing technology. The obtained wafer shows highly crystalline and good densification that can effectively collect the generated charges, which avoids the compound losses and further limits the ion migration. As a result, the related X‐ray detector demonstrates high sensitivity of 5.56 × 103 µC Gyair−1 cm−2, a low detection limit of 8.7 nGyair s−1, fast response (≈10 ms), high‐spatial resolution (≈4.1 lp mm−1), good stability, and imaging capability. Moreover, the integration of the wafer with pixelated electrode substrate is also successfully achieved, applied, and validated with strong mechanical connection and reliable contact.
Solvated Sodium Storage via a Coadsorptive Mechanism in Microcrystalline Graphite Fiber
Authors: Liu Xiaoxu , Wang Tian , Zhang Tengsheng , Sun Zhihao , Ji Tianyi , Tian Jing , Wang Hui , Hao Xiaodong , Liu Hui , Chao Dongliang 
Published: September 2022

AbstractGraphite has been widely accepted for its reversible solvated sodium cointercalation mechanism into the graphite layers in ether‐based electrolytes. However, the cointercalation suffers from insufficient Coulombic efficiency with high redox potentials, which significantly limits its energy output. Herein, instead of the conventional solvated Na+ cointercalation into the graphite, a new coadsorptive mechanism is proposed through the microcrystalline graphite fiber (MCGF), which can reversibly store the solvated Na+ at the ribboned grain boundaries and in the mesopores of the MCGF. The mechanism is manifested by various advanced spectroscopy techniques, including in situ synchrotron small‐angle X‐ray scattering to track the long‐periodic structure evolution and ex situ synchrotron X‐ray absorption fine structure to verify the interaction of solvated Na and graphite layers. The origin of the boosted rate‐capability and reversibility is further revealed by density functional theory simulations and aberration‐corrected transmission electron microscopy. As a proof‐of‐concept, the MCGF electrode exhibits high initial coulombic efficiency (92.5%), fast‐charging (within 4 min), and enhanced cycling stability (≈98% retention after 800 cycles). The results provide a new understanding of the sodium storage mechanism in graphite‐based materials, which may inspire further exploration of carbon electrodes for Na‐ion batteries.
Bifunctional Platinum‐Incorporated Polyoxoniobate Derived Catalyst for N‐formylation of Piperidine Using CO2
Authors: Chudatemiya Vorakit , Kikkawa Soichi , Hirayama Jun , Takahata Ryo , Teranishi Toshiharu , Tamura Masazumi , Yamazoe Seiji 
Published: September 2022

AbstractAlkaline salt of platinum‐incorporated heteropolyoxoniobate [Pt(Nb6O19)2]12− (Pt(Nb6)2) was fabricated and applied for N‐formylation of various amines including piperidine under CO2 and H2 atmosphere. Pt(Nb6)2 achieved the selective formation of 1‐formylpiperidine, whereas the absence of Pt species, H2, and CO2 resulted in a trace amount of the product. The structural characterization revealed that the sandwich‐type structure of Pt(Nb6)2 was transformed into Pt nanoparticles incorporated with polyoxoniobates ([Nb6O19]8−) on the NbOx bulk matrix (NbPOM‐PtNPs/NbOx) under reaction conditions. The N‐formylation of amines in the presence of CO2 and H2 proceeded by the bifunctional NbPOM‐PtNPs/NbOx where the basic sites of [Nb6O19]8− and the redox property of Pt promoted the generation of formamides.
Stimuli Responsive Silylene: Electromerism Induced Reversible Switching Between Mono‐ and Bis‐Silylene
Authors: Yadav Ravi , Sun Xiaofei , Köppe Ralf , Gamer Michael T. , Weigend Florian , Roesky Peter W. 
Published: September 2022

AbstractElectromerism is a very well‐known phenomenon in transition metal chemistry. In main group chemistry, this concept has only started getting attention recently. We report stimuli responsive low‐valent silicon compounds exhibiting electromerism. A mixed‐valent silaiminyl‐silylene1, [LSi−Si(NDipp)L] (L=PhC(NtBu)2), was synthesized in a single step from amidinate‐chlorosilylene. Compound1has two interconnected Si atoms in formally +I and +III oxidation states. Upon treatment with Lewis acidic CuIX (X=mesityl, Cl, Br, I), electron redistribution occurs resulting in the formation of [{LSi(NDipp)Si(L)}−CuX], in which both silicon atoms are in the +II formal oxidation state. Removal of the copper center from [{LSi(NDipp)Si(L)}−CuX] by using a Lewis basic carbene led to reformation of the precursor [LSi−Si(NDipp)L]. Thus, the process is fully reversible. This showcases the first example of Lewis acid/base‐induced reversible electromerism in silicon chemistry.
Erklärbare domänenspezifische Künstliche Intelligenz im Massiv‐ und Brückenbau
Authors: Kraus Michael A. 
Published: September 2022

AbstractDer Einsatz von Künstlicher Intelligenz (KI) wird derzeit flächendeckend in Forschung und Praxis aller Branchen diskutiert und evaluiert. Dieser Beitrag vermittelt zunächst das notwendige Hintergrundwissen zur allgemeinen KI und erarbeitet dann die Notwendigkeit der Entwicklung von domänenspezifischer KI sowie erklärbarer KI (XAI) für die Berechnungs‐ und Bemessungspraxis im Bauwesen. Dabei wird die Rolle der Domäne „Bauingenieurwesen“ an der Schnittstelle zur KI im Hinblick auf Daten sowie Modellierungs‐ und Bemessungsphilosophie diskutiert. Die drei Beispiele (i) Berechnung von Kirchhoff‐Platten mit physikinformierten Neuronalen Netzen, (ii) Kalibrierung von Prior‐Modellen für den parametrischen Brückenentwurf aus Datenbanken und (iii) der KI‐unterstützte konzeptionelle Entwurf von Brücken veranschaulichen die Anwendung von domänenspezifischem Maschinellem und Tiefem Lernen sowie XAI mit besonderem Blick auf den Massiv‐ und Brückenbau. Insbesondere die physikinformierte KI (piKI) stellt eine Alternative zu etablierten numerischen Verfahren unter besonderer Berücksichtigung vorhandener Simulations‐ und Versuchsdaten dar und wird über den Einsatz von XAI erklärbar und nachvollziehbar. Dies ebnet den Weg zur Nutzung der Modelle der piKI im Bauwesen als Digitale Zwillinge eines Tragwerks über deren Lebenszyklen.
A nonparametric method for classification trees using grouped covariates
Authors: Lin Feng‐Chang , Shih Yu‐Shan , Yu Yuan‐Bin 
Published: September 2022

AbstractA group of variables are commonly seen in diagnostic medicine when multiple prognostic factors are aggregated into a composite score to represent the risk profile. A model selection method considers these covariates as all‐in or all‐out types. Model selection procedures for grouped covariates and their applications have thrived in recent years, in part because of the development of genetic research in which gene–gene or gene–environment interactions and regulatory network pathways are considered groups of individual variables. However, little has been discussed on how to utilize grouped covariates to grow a classification tree. In this paper, we propose a nonparametric method to address the selection of split variables for grouped covariates and their following selection of split points. Comprehensive simulations were implemented to show the superiority of our procedures compared to a commonly used recursive partition algorithm. The practical use of our method is demonstrated through a real data analysis that uses a group of prognostic factors to classify the successful mobilization of peripheral blood stem cells.
A Simple Colorimetric Assay of Bleomycin‐Mediated DNA Cleavage Utilizing Double‐Stranded DNA‐Modified Gold Nanoparticles
Authors: Akiyama Yoshitsugu , Kimura Kazunori , Komatsu Syuuhei , Takarada Tohru , Maeda Mizuo , Kikuchi Akihiko 
Published: September 2022

AbstractA colorimetric assay of DNA cleavage by bleomycin (BLM) derivatives was developed utilizing high colloidal stability on double‐stranded (ds) DNA‐modified gold nanoparticles (dsDNA‐AuNPs) possessing a cleavage site. The assay was performed using dsDNA‐AuNPs treated with inactive BLM or activated BLM (Fe(II)⋅BLM). A 10‐min exposure in dsDNA‐AuNPs with inactive BLM treatment resulted in a rapid color change from red to purple because of salt‐induced non‐crosslinking aggregation of dsDNA‐AuNPs. In contrast, the addition of active Fe(II)⋅BLM retained the red color, probably because of the formation of protruding structures at the outermost phase of dsDNA‐AuNPs caused by BLM‐mediated DNA cleavage. Furthermore, the results of our model experiments indicate that oxidative base release and DNA‐cleavage pathways could be visually distinguished with color change. The present methodology was also applicable to model screening assays using several drugs with different mechanisms related to antitumor activity. These results strongly suggest that this assay with a rapid color change could lead to simple and efficient screening of potent antitumor agents.
Effects of Fluid Properties on Rod Seal Stick‐Slip Mechanical and Sound Vibrations
Authors: Ogunsola Oluwaseyi , Shahid Jazil Bin , Michael Paul 
Published: September 2022

AbstractThe effect of fluid properties on hydraulic cylinder rod seal stick‐slip friction was studied. Breakaway and stick‐slip forces were measured for three ISO VG 32 fluids with slipper, U‐cup, and Vee‐pack seals. Breakaway forces increased exponentially with dwell time. Stick‐slip friction produced audible low‐frequency noise. Differences in the stick‐slip behavior of the fluids were observed. Fast Fourier transform analysis of sound, force, and mechanical vibrations was conducted. Stick‐slip friction increased the amplitude of low‐frequency vibrations in all three domains. Micro stick‐slip movement was elucidated via motion amplification technology. These findings provide a basis for the development of fluids that improve the control and safety of hydraulic equipment.
A new perspective to develop regiorandom polymer acceptors with high active layer ductility, excellent device stability, and high efficiency approaching 17%
Authors: Fan Qunping , Ma Ruijie , Su Wenyan , Zhu Qinglian , Luo Zhenghui , Chen Kai , Tang Yabing , Lin Francis R. , Li Yuxiang , Yan He , Yang Chuluo , Jen Alex K.‐Y. , Ma Wei 
Published: September 2022

AbstractThe recently reported efficient polymerized small‐molecule acceptors (PSMAs) usually adopt a regioregular backbone by polymerizing small‐molecule acceptors precursors with a low‐reactivity 5‐brominated 3‐(dicyanomethylidene)indan‐1‐one (IC) end group or its derivatives, leading to low molecular weight, and thus reduce active layer mechanical properties. Herein, a series of newly designed chlorinated PSMAs originating from isomeric IC end groups are developed by adjusting chlorinated positions and copolymerized sites on end groups to achieve high molecular weight, favorable intermolecular interaction, and improved physicochemical properties. Compared with regioregular PY2Se‐Cl‐o and PY2Se‐Cl‐m, regiorandom PY2Se‐Cl‐ran has a similar absorption profile, moderate lowest unoccupied molecular orbital level, and favorable intermolecular packing and crystallization properties. Moreover, the binary PM6:PY2Se‐Cl‐ran blend achieves better ductility with a crack‐onset strain of 17.5% and improved power conversion efficiency (PCE) of 16.23% in all‐polymer solar cells (all‐PSCs) due to the higher molecular weight of PY2Se‐Cl‐ran and optimized blend morphology, while the ternary PM6:J71:PY2Se‐Cl‐ran blend offers an impressive PCE approaching 17% and excellent device stability, which are all crucial for potential practical applications of all‐PSCs in wearable electronics. To date, the efficiency of 16.86% is the highest value reported for the regiorandom PSMAs‐based all‐PSCs and is also one of the best values reported for the all‐PSCs. Our work provides a new perspective to develop efficient all‐PSCs, with all high active layer ductility, impressive PCE, and excellent device stability, towards practical applications.