bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of interventions to address obesity and health risk behaviours among people with severe mental illness in low- and middle-income countries (LMICs): a systematic review and meta analysis
Authors: Zavala Gerardo A. , Todowede Olamide , Mazumdar Papiya , Aslam Faiza , Choudhury Asiful Haidar , Jarde Alexander , Khalid Humaira , Reddy Sadananda , Gilbody Simon , Siddiqi Najma 
Published: June 2022

AbstractIntroductionPeople with severe mental illness (SMI) are more likely to have obesity and engage in health risk behaviours than the general population. The aims of this study are (1) evaluate the effectiveness of interventions that focus on body weight, smoking cessation, improving sleeping patterns, and alcohol and illicit substance abuse; (2) Compare the number of interventions addressing body weight and health risk behaviours in low- and middle-income countries (LMICs) v. those reported in published systematic reviews focusing on high-income countries (HICs).MethodsIntervention studies published up to December 2020 were identified through a structured search in the following database; OVID MEDLINE (1946–December 2020), EMBASE (1974–December 2020), CINAHL (1975–2020), APA PsychoINFO (1806–2020). Two authors independently selected studies, extracted study characteristics and data and assessed the risk of bias. and risk of bias was assessed using the Cochrane risk of bias tool V2. We conducted a narrative synthesis and, in the studies evaluating the effectiveness of interventions to address body weight, we conducted random-effects meta-analysis of mean differences in weight gain. We did a systematic search of systematic reviews looking at cardiometabolic and health risk behaviours in people with SMI. We compared the number of available studies of LMICs with those of HICs.ResultsWe assessed 15 657 records, of which 9 met the study inclusion criteria. Six focused on healthy weight management, one on sleeping patterns and two tested a physical activity intervention to improve quality of life. Interventions to reduce weight in people with SMI are effective, with a pooled mean difference of −4.2 kg (95% CI −6.25 to −2.18, 9 studies, 459 participants, I2 = 37.8%). The quality and sample size of the studies was not optimal, most were small studies, with inadequate power to evaluate the primary outcome. Only two were assessed as high quality (i.e. scored ‘low’ in the overall risk of bias assessment). We found 5 reviews assessing the effectiveness of interventions to reduce weight, perform physical activity and address smoking in people with SMI. From the five systematic reviews, we identified 84 unique studies, of which only 6 were performed in LMICs.ConclusionPharmacological and activity-based interventions are effective to maintain and reduce body weight in people with SMI. There was a very limited number of interventions addressing sleep and physical activity and no interventions addressing smoking, alcohol or harmful drug use. There is a need to test the feasibility and cost-effectiveness of context-appropriate interventions to address health risk behaviours that might help reduce the mortality gap in people with SMI in LMICs.
ALGEBRAIC EXPANSIONS OF LOGICS
Authors: CAMPERCHOLI MIGUEL , CASTAÑO DIEGO NICOLÁS , DÍAZ VARELA JOSÉ PATRICIO , GISPERT JOAN 
Published: June 2022

AbstractAn algebraically expandable (AE) class is a class of algebraic structures axiomatizable by sentences of the form
$\forall \exists ! \mathop{\boldsymbol {\bigwedge }}\limits p = q$
. For a logic L algebraized by a quasivariety
$\mathcal {Q}$
we show that the AE-subclasses of
$\mathcal {Q}$
correspond to certain natural expansions of L, which we call algebraic expansions. These turn out to be a special case of the expansions by implicit connectives studied by X. Caicedo. We proceed to characterize all the AE-subclasses of abelian
$\ell $
-groups and perfect MV-algebras, thus fully describing the algebraic expansions of their associated logics.
Is septoplasty required whenever anterior septal deviation is present?
Authors: Susaman N , Çetiner H 
Published: June 2022

AbstractObjectivePost-operative success and patient satisfaction were assessed following septoplasty for mild to severe anterior septal deviation.MethodsThe study included patients with an anterior nasal septal deviation in the form of a ‘C’ shape and close to the nasal valve in the anterior septal area. Deviation severity was classified as severe (group 1), moderate (group 2) or mild (group 3). Open or closed septoplasty procedures were performed. All patients were surveyed twice using the Nasal Obstruction Symptom Evaluation scale and the 36-Item Short Form Health Survey.ResultsThe mean Nasal Obstruction Symptom Evaluation score for group 1 was 15.58 ± 2.34 prior to surgery and 6.61 ± 3.29 following surgery. The corresponding pre- and post-surgery scores in group 2 were 11.9 ± 2.82 and 6.3 ± 3.03, respectively. In group 3, these values were 8.28 ± 2.63 and 7.12 ± 3.18, respectively. The mean 36-Item Short Form Health Survey physical function value for groups 1 and 2 increased after surgery; in group 3, this value decreased after surgery, but the result was not statistically significant.ConclusionSeptoplasty is very successful for treating moderate or advanced deviations, but great care should be taken when employing septoplasty for mild deviations.
Unrepaired tetralogy of Fallot in the adult: an unexpected diagnosis
Authors: Garcia Brás Pedro , Branco Mano Tânia , Sousa Lídia 
Published: June 2022

AbstractA 40-year-old female is admitted for paroxysmal episodes of exertional dyspnoea, with associated cyanosis, improving with squatting, and a holosystolic murmur radiating to the interscapular area. Echocardiography showed a subaortic ventricular septal defect with left-to-right shunt and overriding aorta. The characteristic murmur prompted us to seek right ventricular outflow tract obstruction. Magnetic resonance was performed, confirming Tetralogy of Fallot, and corrective surgery was performed.
Infant’s difficult temperament characteristics predict poor quality of life in parents of infants with complex CHDs post-cardiac surgery
Authors: Golfenshtein Nadya , Lisanti Amy J. , Medoff-Cooper Barbara 
Published: June 2022

AbstractBackground & Aims:Parents of infants with complex CHDs often describe their infants as especially fussy, irritable, and difficult to sooth, which together with the illness caretaking demands add to their stress. Little is known about how the behavioural style or temperament in the early months after discharge relates to parental quality of life. This study aimed to explore the associations between early infant temperament characteristics and parental quality of life in parents of infants with complex CHD.Methods:This descriptive, cross-sectional study, utilised data collected in a previously described multisite randomised clinical trial in the United States. Multivariable linear regression models were used to examine the associations of interest.Findings:Results demonstrated negative significant associations between most infant temperament subscales and parental quality of life. Higher scores on the Activity (β = −3.03, p = 0.021), Approach (β = −1.05, p = 0.021), Adaptability (β = −3.47, p = 0.004), Intensity (β = −2.78, p = 0.008), Mood (β = −4.65, p < 0.001), and Distractibility (β = −3.36, p = 0.007 were all significantly associated with lower parental quality of life scores, adjusting for parental dyadic adjustment, insurance type, number of medications, and number of unscheduled cardiologist visits.Conclusions:Parental perceptions of infant’s difficult behavioural style or temperament characteristics appear to be associated with poorer quality of life in parents of infants with complex CHD post-cardiac surgery. Findings can be used in the screening process of families at potential risk of increased stress and poor illness adaptation and in the design of interventions to target parental mental health in this vulnerable patient population.
You Better Vote: Drag Performers and Voter Mobilization in the 2020 Election
Authors: Kammerer Edward F. , Michelson Melissa R. 
Published: June 2022

ABSTRACTDrag has long been part of the LGBTQ rights movement. Drag performers play an important role as community leaders and political activists. Today, drag performers are also popular celebrities in the rest of society. This article explores the role of drag performers as community leaders and celebrities in the context of the 2020 presidential election. To understand this, we interviewed drag performers about their experiences using drag to mobilize voters. Research shows that Get Out The Vote (GOTV) efforts are more successful if they are led by volunteers and include trusted messengers while still being unexpected in some way. Drag performers are community leaders and volunteers and, when speaking about politics, deliver unexpected—and thus memorable—messages. The drag performers that we interviewed demonstrate the potential for drag artists to be effective GOTV messengers, in both the LGBTQ community and society more broadly.
Hearing the Musical Resonances of Catastrophe
Authors: ANDERTON ABBY , SPRIGGE MARTHA 
Published: June 2022

AbstractThis collection of articles proposes a theoretical model for understanding and analysing the persistence of music making as a response to urban catastrophe. In the Introduction, the authors present an overview of recent humanistic literature on ruin aesthetics, positioning music as a vital yet overlooked dimension of aesthetic responses to disaster. The forum delves into the moral and ethical complexities of performing in ruins from second-century Jerusalem to contemporary Haiti. By tracing the sound of music in and about ruins, this forum offers a timely reflection on the nature of post-catastrophic music making, proposing new directions for analysing the relationships between music, traumatic memory, and spaces of performance.
Damage and Renewal at the Württembergische Staatstheater, Stuttgart
Authors: POLLOCK EMILY RICHMOND 
Published: June 2022

AbstractThe dual theatre complex of the Württembergische Staatstheater in Stuttgart sustained serious damage during the Second World War. While the larger theatre was eventually able to be repaired, the smaller theatre was destroyed, leading to a multi-phased and controversial process to determine how best to replace it. Many of Stuttgart's citizens publicly pleaded that the smaller theatre should be reconstructed according to its original design, in order to restore its historical beauty and its integrity with the complex. The company's Intendant and numerous architects, however, took a more modern approach that manifested in a variety of proposed designs, including that by Hans Volkart, which opened in 1962. Countering the binary represented by ‘faithful reconstruction’ on one end (Vienna, Munich) and by completely modern designs on the other (West Berlin, Cologne), the case of Stuttgart perhaps serves as a better metaphor for the compromises of continuity and change in post-war culture.
Destroying the Imagined City
Authors: PHILLIPS-HUTTON ARIANA 
Published: June 2022

AbstractThe transformation of rubble into aestheticized ruins turns on the relation of aesthetics, politics, and power alongside questions of memory, imagination, and embodiment. Working outward from this suggestive confluence, I investigate contemporary practices of commemorative composition that resituate elements of the historical archive, and so turn sonic rubble into ruin. Using Mary Kouyoumdjian's 2014 composition Bombs of Beirut as an example, I consider how the composer uses witness testimony and archival recordings of wartime sounds from the Lebanese Civil War (1975–90) to first construct, and then destroy, a version of the city of Beirut. In so doing, she engages in what Marianne Hirsch would call a ‘postmemorial act’ that reconfigures the relationships between physical, mental, and social spaces. The resulting palimpsest of meanings not only offers an important contemplative space for approaching the past but also suggests intriguing futures for the musical art of the ruin.
Hearing Global Britishness on the BBC'sCommonwealth of Song(1953–1961)
Authors: NELSON TREVOR R. 
Published: June 2022

AbstractPart of the United Kingdom's national reconstruction following the Second World War was reforming its self-image as a global power in light of imperial decline. This recasting took place across political and cultural spheres and emphasized the Commonwealth, idealized as a friendly collection of current and former colonies linked by British culture. In this article, I demonstrate how music broadcasting functioned as a site of diplomacy, using white, middle-class taste for light entertainment to reinforce British values at the Empire's twilight. I focus on musical depictions of the Commonwealth on the BBC radio programmeCommonwealth of Song. Using archival records, I reconstruct debates concerning Commonwealth representation and its importance to British citizens. I argue thatCommonwealth of Songwas a site of testing and reformulating new sonic constructions of globally minded ‘Britishness’ in the 1950s, yet conflicting messaging about what musics and people should represent the Commonwealth led to a lukewarm reception.
Always Already and Never Yet: Does China Even Have a Present?
Authors: Lanza Fabio 
Published: June 2022

AbstractThis essay traces how China's changing presents have been represented in Anglo-American discourse and in China studies from the Cold War to today. It shows how, in popular opinion but also in academia, that discourse has displayed a stubborn tendency to explain—or rather explain away—China's presents, configuring them strictly in relation to pasts that can never be overcome and futures that are either never realized or always dangerously looming. This ideological framing has its roots in Cold War anticommunism, which was foundational to China studies in the US, but lingers on to this day, as China's coevalness is continuously denied.
Has the Adaptation‐Mitigation Binary Outlived Its Value? Indigenous Ways of Knowing Present an Alternative
Authors: Ullmann Anna L. , Kassam Karim‐Aly S. 
Published: June 2022

AbstractCommunity‐level actions addressing anthropogenic climate change are paramount to survival. However, there are limitations to the current binary approach which considers adaptation and mitigation as mutually exclusive actions. Drawing from research in the Pamir Mountains of Tajikistan, this commentary demonstrates: (a) Indigenous knowledge, emerging from a deep connectivity to habitat, cumulative over generations, and empirically‐based, is the foundation of ecological calendars; (b) ecological calendars build anticipatory capacity, the ability to envision possible and sustainable futures, for anthropogenic climate change; and (c) this anticipatory approach engages adaptive and mitigative actions to climate change working in tandem to ensure wellbeing and food security. This paper maintains that the adaptation‐mitigation continuum involves foresight and action today in preparation for future change. Furthermore, context‐specific ecological calendars represent an effective mechanism for communities to build and retain knowledge across generations and deep connections to their habitat. Finally, further modeling needs to be undertaken with participation and leadership from Indigenous and rural communities to understand how they use the adaptation‐mitigation continuum for anticipatory action to develop multiple optimal solutions to address environmental change.
Optimizing a Model of Coseismic Rupture for the 22 July 2020MW7.8 Simeonof Earthquake by Exploiting Acute Sensitivity of Tsunami Excitation Across the Shelf Break
Authors: Bai Yefei , Liu Chengli , Lay Thorne , Cheung Kwok Fai , Ye Lingling 
Published: June 2022

AbstractThe Shumagin seismic gap along the Alaska Peninsula experienced a major,MW7.8, interplate thrust earthquake on 22 July 2020. Several available finite‐fault inversions indicate patchy slip of up to 4 m at 8–48 km depth. There are differences among the models in peak slip and absolute placement of slip on the plate boundary, resulting from differences in data distributions, model parameterizations, and inversion algorithms. Two representative slip models obtained from inversions of large seismic and geodetic data sets produce very different tsunami predictions at tide gauges and deep‐water pressure sensors (DART stations), despite having only secondary differences in slip distribution. This is found to be the result of the acute sensitivity of the tsunami excitation for rupture below the continental shelf in proximity to an abrupt shelf break. Iteratively perturbing seismic and geodetic inversions by constraining fault model extent along dip and strike, we obtain an optimal rupture model compatible with teleseismicPandSHwaves, regional three‐component broadband and strong‐motion seismic recordings, hr‐GNSS time series and static offsets, as well as tsunami recordings at DART stations and regional and remote tide gauges. Slip is tightly bounded between 25 and 40 km depth, the up‐dip limit of slip in the earthquake is resolved to be well‐inland of the shelf break, and the rupture extent along strike is well‐constrained. The coseismic slip increased Coulomb stress on the shallow plate boundary extending to the trench, but the frictional behavior of the megathrust below the continental slope remains uncertain.
Inhibition of glutamate-carboxypeptidase-II in dorsolateral prefrontal cortex: potential therapeutic target for neuroinflammatory cognitive disorders
Authors: Yang Shengtao , Datta Dibyadeep , Elizabeth Woo  , Duque Alvaro , Morozov Yury M. , Arellano Jon , Slusher Barbara S. , Wang Min , Arnsten Amy F. T. 
Published: June 2022

AbstractGlutamate carboxypeptidase-II (GCPII) expression in brain is increased by inflammation, e.g. by COVID19 infection, where it reduces NAAG stimulation of metabotropic glutamate receptor type 3 (mGluR3). GCPII-mGluR3 signaling is increasingly linked to higher cognition, as genetic alterations that weaken mGluR3 or increase GCPII signaling are associated with impaired cognition in humans. Recent evidence from macaque dorsolateral prefrontal cortex (dlPFC) shows that mGluR3 are expressed on dendritic spines, where they regulate cAMP-PKA opening of potassium (K+) channels to enhance neuronal firing during working memory. However, little is known about GCPII expression and function in the primate dlPFC, despite its relevance to inflammatory disorders. The present study used multiple label immunofluorescence and immunoelectron microscopy to localize GCPII in aging macaque dlPFC, and examined the effects of GCPII inhibition on dlPFC neuronal physiology and working memory function. GCPII was observed in astrocytes as expected, but also on neurons, including extensive expression in dendritic spines. Recordings in dlPFC from aged monkeys performing a working memory task found that iontophoresis of the GCPII inhibitors 2-MPPA or 2-PMPA markedly increased working memory-related neuronal firing and spatial tuning, enhancing neural representations. These beneficial effects were reversed by an mGluR2/3 antagonist, or by a cAMP-PKA activator, consistent with mGluR3 inhibition of cAMP-PKA-K+ channel signaling. Systemic administration of the brain penetrant inhibitor, 2-MPPA, significantly improved working memory performance without apparent side effects, with largest effects in the oldest monkeys. Taken together, these data endorse GCPII inhibition as a potential strategy for treating cognitive disorders associated with aging and/or neuroinflammation.
Proteomic analysis reveals USP7 as a novel regulator of palmitic acid-induced hepatocellular carcinoma cell death
Authors: Saha Sandhini , Verma Rohit , Kumar Chandan , Kumar Bhoj , Dey Amit Kumar , Surjit Milan , Mylavarapu Sivaram V. S. , Maiti Tushar Kanti 
Published: June 2022

AbstractNutrient surplus and consequent free fatty acid accumulation in the liver cause hepatosteatosis. The exposure of free fatty acids to cultured hepatocyte and hepatocellular carcinoma cell lines induces cellular stress, organelle adaptation, and subsequent cell death. Despite many studies, the mechanism associated with lipotoxicity and subsequent cell death still remains poorly understood. Here, we have used the proteomics approach to circumvent the mechanism for lipotoxicity using hepatocellular carcinoma cells as a model. Our quantitative proteomics data revealed that ectopic lipids accumulation in cells severely affects the ubiquitin-proteasomal system. The palmitic acid (PA) partially lowered the expression of deubiquitinating enzyme USP7 which subsequently destabilizes p53 and promotes mitotic entry of cells. Our global phosphoproteomics analysis also provides strong evidence of an altered cell cycle checkpoint proteins’ expression that abrogates early G2/M checkpoints recovery with damaged DNA and induced mitotic catastrophe leading to hepatocyte death. We observe that palmitic acid prefers apoptosis-inducing factor (AIF) mediated cell death by depolarizing mitochondria and translocating AIF to the nucleus. In summary, the present study provides evidence of PA-induced hepatocellular death mediated by deubiquitinase USP7 downregulation and subsequent mitotic catastrophe.
Branched actin networks are organized for asymmetric force production during clathrin-mediated endocytosis in mammalian cells
Authors: Jin Meiyan , Shirazinejad Cyna , Wang Bowen , Yan Amy , Schöneberg Johannes , Upadhyayula Srigokul , Xu Ke , Drubin David G. 
Published: June 2022

AbstractActin assembly facilitates vesicle formation in several trafficking pathways, including clathrin-mediated endocytosis (CME). Interestingly, actin does not assemble at all CME sites in mammalian cells. How actin networks are organized with respect to mammalian CME sites and how assembly forces are harnessed, are not fully understood. Here, branched actin network geometry at CME sites was analyzed using three different advanced imaging approaches. When endocytic dynamics of unperturbed CME sites are compared, sites with actin assembly show a distinct signature, a delay between completion of coat expansion and vesicle scission, indicating that actin assembly occurs preferentially at stalled CME sites. In addition, N-WASP and the Arp2/3 complex are recruited to one side of CME sites, where they are positioned to stimulate asymmetric actin assembly and force production. We propose that actin assembles preferentially at stalled CME sites where it pulls vesicles into the cell asymmetrically, much as a bottle opener pulls off a bottle cap.
Dielectric magnetochiral anisotropy
Authors: Rikken Geert L. J. A. , Avarvari Narcis 
Published: June 2022

AbstractThe combination of chirality and magnetism has steadily grown over the last decennia into an area of intense research. Magnetochiral anisotropy, chirality-induced spin-selectivity and helimagnetism are the most prominent phenomena resulting from this combination, touching different systems like topological (semi-)metals and insulators, quantum magnets, type II multiferroics and enantio-selective synthesis. As an extension to this area, we argue, based on symmetry arguments, that magnetochiral anisotropy will manifest itself in the displacement current in chiral dielectrics in a magnetic field. We confirm this conjecture by the experimental observation of very strong dielectric magnetochiral anisotropy near the ferroelectric phase transitions of triglycine sulfate and Rochelle salt, two of the oldest and most investigated chiral ferroelectrics. This effect opens a new playground in the study and characterisation of all chiral dielectrics. With our discovery, magnetochiral anisotropy now covers the (di)electrical properties of all condensed matter, from insulators to superconductors.