bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unanticipated daytime melatonin secretion on a simulated night shift schedule generates a distinctive 24‐h melatonin rhythm with antiphasic daytime and nighttime peaks
Authors: Qian Jingyi , Morris Christopher J. , Phillips Andrew J. K. , Li Peng , Rahman Shadab A. , Wang Wei , Hu Kun , Arendt Josephine , Czeisler Charles A. , Scheer Frank A. J. L. 
Published: February 2022

AbstractThe daily rhythm of plasma melatonin concentrations is typically unimodal, with one broad peak during the circadian night and near‐undetectable levels during the circadian day. Light at night acutely suppresses melatonin secretion and phase shifts its endogenous circadian rhythm. In contrast, exposure to darkness during the circadian day has not generally been reported to increase circulating melatonin concentrations acutely. Here, in a highly‐controlled simulated night shift protocol with 12‐h inverted behavioral/environmental cycles, we unexpectedly found that circulating melatonin levels were significantly increased during daytime sleep (p < .0001). This resulted in a secondary melatonin peak during the circadian day in addition to the primary peak during the circadian night, when sleep occurred during the circadian day following an overnight shift. This distinctive diurnal melatonin rhythm with antiphasic peaks could not be readily anticipated from the behavioral/environmental factors in the protocol (e.g., light exposure, posture, diet, activity) or from current mathematical model simulations of circadian pacemaker output. The observation, therefore, challenges our current understanding of underlying physiological mechanisms that regulate melatonin secretion. Interestingly, the increase in melatonin concentration observed during daytime sleep was positively correlated with the change in timing of melatonin nighttime peak (p = .002), but not with the degree of light‐induced melatonin suppression during nighttime wakefulness (p = .92). Both the increase in daytime melatonin concentrations and the change in the timing of the nighttime peak became larger after repeated exposure to simulated night shifts (p = .002 and p = .006, respectively). Furthermore, we found that melatonin secretion during daytime sleep was positively associated with an increase in 24‐h glucose and insulin levels during the night shift protocol (p = .014 and p = .027, respectively). Future studies are needed to elucidate the key factor(s) driving the unexpected daytime melatonin secretion and the melatonin rhythm with antiphasic peaks during shifted sleep/wake schedules, the underlying mechanisms of their relationship with glucose metabolism, and the relevance for diabetes risk among shift workers.
OsEIL1 protects rice growth under NH4+ nutrition by regulating OsVTC1‐3‐dependent N‐glycosylation and root NH4+ efflux
Authors: Li Guangjie , Zhang Lin , Wu Jinlin , Yue Xiaowei , Wang Meng , Sun Li , Di Dongwei , Kronzucker Herbert J. , Shi Weiming 
Published: February 2022

AbstractRice is known for its superior adaptation to ammonium (NH4+) as a nitrogen source. Compared to many other cereals, it displays lower NH4+ efflux in roots and higher nitrogen‐use efficiency on NH4+. A critical role for GDP‐mannose pyrophosphorylase (VTC1) in controlling root NH4+ fluxes was previously documented in Arabidopsis, but the molecular pathways involved in regulating VTC1‐dependent NH4+ efflux remain unclear. Here, we report that ETHYLENE‐INSENSITIVE3‐LIKE1 (OsEIL1) acts as a key transcription factor regulating OsVTC1‐3‐dependent NH4+ efflux and protein N‐glycosylation in rice grown under NH4+ nutrition. We show that OsEIL1 in rice plays a contrasting role to Arabidopsis‐homologous ETHYLENE‐INSENSITIVE3 (AtEIN3) and maintains rice growth under NH4+ by stabilizing protein N‐glycosylation and reducing root NH4+ efflux. OsEIL1 constrains NH4+ efflux by activation of OsVTC1‐3, but not OsVTC1‐1 or OsVTC1‐8. OsEIL1 binds directly to the promoter EIN3‐binding site (EBS) of OsVTC1‐3 in vitro and in vivo and acts to increase the transcription of OsVTC1‐3. Our work demonstrates an important link between excessive root NH4+ efflux and OsVTC1‐3‐mediated protein N‐glycosylation in rice grown under NH4+ nutrition and identifies OsEIL1 as a direct genetic regulator of OsVTC1‐3 expression.
Thermal tolerance of Hypnea pseudomusciformis ecotypes (Cystocloniaceae, Rhodophyta) related to different floristic provinces along the Brazilian coast
Authors: Nauer Fabio , Cabral Oliveira Mariana , Plastino Estela Maria , Sumie Yokoya Nair , Toyota Fujii Mutue 
Published: February 2022

SUMMARYStudies on the effects of temperature on physiological processes are essential to model macroalgae biogeographic distribution. Tetrasporophytes of Hypnea pseudomusciformis were collected from three floristic provinces (tropical, transition and warm temperate) along the Brazilian coast (~3.000 km), representing three ecotypes. Specimens were cultured under 20°C, 24°C, 28°C and 32°C for 21 days, then physiological parameters (growth rates, photosynthesis and pigments content) were analyzed. H. pseudomusciformis specimens tolerated a temperature variation from 20°C to 32°C. However, all ecotypes displayed a significant decrease in physiological performance at 32°C in all parameters analyzed. We hypothesized that the H. pseudomusciformis ecotype from the tropical province is already living at its thermal physiological limit, reaching its maximum growth only in the winter months (June to September), whereas a warm temperate ecotype reaches maximum growth in the summer months (December to March). This wide thermal optimum may be the reason for the widespread distribution of this species along the Brazilian coast, allowing it to occupy different thermal environments.
Cauchy matrix approach to the SU(2) self‐dual Yang–Mills equation
Authors: Li Shangshuai , Qu Changzheng , Yi Xiangxuan , Zhang Da‐jun 
Published: February 2022

AbstractThe Cauchy matrix approach is developed to solve the self‐dual Yang–Mills (SDYM) equation. Starting from a Sylvester matrix equation coupled with certain dispersion relations for an infinite number of coordinates, we derive some new relations that give rise to the SDYM equation under Yang's formulation. By imposing further constraints on complex independent variables, a broad class of explicit solutions of the equation under Yang's formulation are obtained.
Alpha lipoic acid toxicosis in cats (2008‐2016): Four cases
Authors: Carpenter Marcia M. , Hovda Lynn R. 
Published: February 2022

AbstractObjectiveTo review clinical signs, treatments, and outcome of 4 cases in cats after ingestion of alpha lipoic acid.Case series summaryFour cases with known alpha lipoic acid ingestions developed clinical signs. A consistent clinical sign in all cases was vomiting, while 2 of the 4 cases resulted in death.New or unique information providedThis is the first reported case series of alpha lipoic acid ingestions in cats.
A Reduced Model Based on Proper Generalized Decomposition for the Fast Analysis of IGBT Power Modules Lifetime
Authors: Schuler Louis , Chamoin Ludovic , Khatir Zoubir , Berkani Mounira , Ouhab Merouane , Degrenne Nicolas 
Published: February 2022

AbstractA reduced weakly-coupled thermo-mechanical model based on the proper generalized decomposition method was developed for the numerical analysis of power modules. The employed model reduction method enabled us to obtain, in a preliminary offline phase, the solution of the thermo-mechanical problem over a large range of design parameters, with much time saving compared to a classical (brute force) multi-resolution finite element method. In an online postprocessing phase, the power module lifetime, modeled with a strain-life law, was then computed in a straightforward manner by rapidly evaluating the solution for any value of the parameters. Sensitivity analysis was conducted to select parameters values leading to acceptable module lifetimes with respect to given criteria. A robust design study was also performed to illustrate the performance of the proposed approach.
Failures in emergency management of pediatric airway foreign bodies by rigid bronchoscopy: we have yet to complete our learning
Authors: Moslehi Mohammad Ashkan 
Published: February 2022

BackgroundSeveral children are affected by airway foreign body aspiration (FBA) resulting from life-threatening conditions. Choking has been considered the major symptom and is defined as airway blockage by a foreign body (FB), leading to marked morbidity or mortality. This retrospective study indicates the possibility of misdiagnosis or rigid bronchoscope (RB) failure, which is the standard gold method for extracting FB in the airway.MethodsSix children with airway FBA who failed treatment using RB between 2018 and 2019 were retrospectively studied. The inclusion criterion was a history of failure to extract FB using RB followed by flexible fiberoptic bronchoscopy (FFB).ResultsIn the present study, among 63 patients who had undergone rigid bronchoscopy, airway FBs were successfully removed in 57 (90.48%). Rigid bronchoscopy failed in 6 (9.52%) patients. The age of cases at the time of bronchoscopy ranged from 11 months to 13 years. FFB was performed to extract missing or remaining FBs and was done successfully in all patients. The patients made an uneventful recovery following FB extraction using the FFB method.ConclusionsIt is not easy to diagnose and treat airway FB in children. Rigid bronchoscopy has been approved as a method to manage airway FB, but a negative bronchoscopy result must usually be interpreted carefully. FFB is applicable as a proper and relatively safe diagnostic and therapeutic tool in managing airway FBs among the pediatric population, especially in cases where rigid bronchoscopy was performed but missed or failed to extract the FB.
The first eigenvalue for the p-Laplacian on Lagrangian submanifolds in complex space forms
Authors: Ali Akram , Lee Jae Won , Alkhaldi Ali H. 
Published: February 2022

The goal of this paper is to prove new upper bounds for the first positive eigenvalue of the [Formula: see text]-Laplacian operator in terms of the mean curvature and constant sectional curvature on Riemannian manifolds. In particular, we provide various estimates of the first eigenvalue of the [Formula: see text]-Laplacian operator on closed orientate [Formula: see text]-dimensional Lagrangian submanifolds in a complex space form [Formula: see text] with constant holomorphic sectional curvature [Formula: see text]. As applications of our main theorem, we generalize the Reilly-inequality for the Laplacian [R. C. Reilly, On the first eigenvalue of the Laplacian for compact submanifolds of Euclidean space, Comment. Math. Helv. 52(4) (1977) 525–533] to the [Formula: see text]-Laplacian for a Lagrangian submanifold in a complex Euclidean space and complex projective space for [Formula: see text] and [Formula: see text], respectively.
Dendrite Growth of Lithium through Separator Using In Situ Measurement Technique
Authors: Arise Ichiro , Miyahara Yuto , Miyazaki Kohei , Abe Takeshi 
Published: February 2022

In situ techniques as a clue to clarify the mechanism of lithium dendrite growth through the separator were applied. The aim of this work was to clarify the dendrite growth mechanism through the separator and to investigate and discuss the relationship between lithium intercalation into graphite and lithium deposition on the graphite surface, applying in situ and ex situ optical microscope and in situ electrochemical impedance spectroscopy. It was visually characterized the lithium dendrite growth by the ionic transfer through the separator and obtained the fundamental knowledge by in situ optical microscope. In the case of lithium deposition through the aramid coated separator (ACS), the dendrites were observed to be granular over a wide area. On the other hand, in the case of lithium deposition through the ceramic coated separator (CCS), dendrites were fibrous over a wide area by ex situ optical microscope.
The superiority of ACS is related to the flatness and uniformity of the pores due to aramid resin. This result was supported by an analysis applying in situ electrochemical impedance spectroscopy.
Musculoskeletal Pain Is Associated with Dietary Diversity Score among Community-Dwelling Older Adult: A Cross-Sectional Study
Authors: Tajary Zahra , Esmaeily Zahra , Rezaei Mahshid , Daei Shahrzad , Eyvazkhani Atefeh , Dara Marjan Mansouri , Motlagh Ahmad Reza Dorosty 
Published: February 2022

Background. Musculoskeletal pains (MSP) are the most common cause of long-term severe pain and physical disability among older adults. This study is aimed at determining the relationship between dietary diversity score (DDS) and MSP in Tehran’s older adults. Methods. The study was a cross-sectional one that employed 213 participants with and without MSP complaints between May and October 2019 in Tehran, Iran. A 100 mm length visual analog scale questionnaire was used to assess pain along with a validated 147-item food frequency questionnaire for DDS evaluation. Statistical analyses included descriptive analysis and multiple linear regression with a significance level of

p
<
0.05

. Results. 85% of the participants had a range of MSP with a low but insignificant DDS compared to individuals without pain (

p
=
0.12

,

3.24

±
0.86

vs.

3.43

±
0.85

, respectively). A significant association was observed among the quartiles of DDS that most of the subjects with MSP were in the lowest quartile relative to the highest one (

p
=
0.02

). Moreover, the association between DDS and MSP remained significant in the adjusted model (

OR
=
0.28

,

95
%

CI

=
0.08
−
0.99

). Conclusion. A high-quality diet is important. Our study showed that a higher dietary diversity might be associated with lower MSP in older adults. More robust interventional studies are thus warranted to confirm the results.
The Risk Factors of Nonalcoholic Fatty Liver Disease in Morbidly Obese Patients Undergoing Bariatric Surgery in Iran
Authors: Aghakhani Ladan , Haghighat Neda , Amini Masoud , Hosseini Seyed Vahid , Masoumi Seyed Jalil 
Published: February 2022

Background and Aims. Nonalcoholic fatty liver disease (NAFLD) is common in severely obese individuals undergoing bariatric surgery. Assessing the prevalence and severity of NAFLD seems crucial since it may affect the prevention or development of more severe forms of fatty liver. Methods. This cross-sectional study was conducted on 228 severely obese individuals undergoing bariatric surgery. Abdominal ultrasonography was done, and clinical and biochemical factors (liver enzymes, lipid profile, and fasting blood sugar (FBS)) were assessed. Results. The mean body mass index (BMI) was

43.45
±
5.92

kg/m2. The prevalence of NAFLD was 49.12% (mild steatosis: 37.5%, moderate steatosis: 36.6%, and severe steatosis: 25.8%). The main risk factors of NAFLD were weight (

p
=
0.002

), BMI (

p
=
0.003

), alanine aminotransferase (ALT) (

p
<
0.001

), aspartate aminotransferase (AST) (

p
<
0.001

), serum triglycerides (TGs) (

p
=
0.004

), and FBS (

p
=
0.039

). The results revealed a statistically significant decrease in the mean level of high-density lipoprotein cholesterol (HDL-C) (

p
=
0.044

). However, no significant association was found between the severity of liver steatosis and the presence of comorbidities such as hypertension, diabetes, hypothyroidism, and dyslipidemia. Conclusions. More severe NAFLD was associated with increased weight and BMI. Elevated ALT, AST, TG, and FBS levels and decreased HDL-C levels were also the risk factors of NAFLD and its progress to more severe conditions.
Literacia comunicacional
Authors: Carareto Mariana 
Published: February 2022

Resenha da obra- As relações públicas e a educação corporativa: uma interface possível
Autora: Roseane Andrelo
Editora Unesp Digital
São Paulo, 2016
99 páginas
Disponível em E-book: http://editoraunesp.com.br/catalogo/9788568334775,as-relacoes-publicas-e-a-educacao-corporativa
CELSR1
Risk Alleles in Familial Bicuspid Aortic Valve and Hypoplastic Left Heart Syndrome
Authors: Theis Jeanne L. , Niaz Talha , Sundsbak Rhianna S. , Fogarty Zachary C. , Bamlet William R. , Hagler Donald J. , Olson Timothy M. 
Published: February 2022

Background:
Whole-genome sequencing in families enables deciphering of congenital heart disease causes. A shared genetic basis for familial bicuspid aortic valve (BAV) and hypoplastic left heart syndrome (HLHS) was postulated.

Methods:
Whole-genome sequencing was performed in affected members of 6 multiplex BAV families, an HLHS cohort of 197 probands and 546 relatives, and 813 controls. Data were filtered for rare, predicted-damaging variants that cosegregated with familial BAV and disrupted genes associated with congenital heart disease in humans and mice. Candidate genes were further prioritized by rare variant burden testing in HLHS cases versus controls. Modifier variants in HLHS proband-parent trios were sought to account for the severe developmental phenotype.

Results:

In 5 BAV families, missense variants in 6 ontologically diverse genes for structural (
SPTBN1
,
PAXIP1
, and
FBLN1
) and signaling (
CELSR1
,
PLXND1
, and
NOS3
) proteins fulfilled filtering metrics.
CELSR1
, encoding cadherin epidermal growth factor laminin G seven-pass G-type receptor, was identified as a candidate gene in 2 families and was the only gene demonstrating rare variant enrichment in HLHS probands (
P
=0.003575). HLHS-associated
CELSR1
variants included 16 missense, one splice site, and 3 noncoding variants predicted to disrupt canonical transcription factor binding sites, most of which were inherited from a parent without congenital heart disease. Filtering whole-genome sequencing data for rare, predicted-damaging variants inherited from the other parent revealed 2 cases of
CELSR1
compound heterozygosity, one case of
CELSR1
-
CELSR3
synergistic heterozygosity, and 4 cases of
CELSR1
-
MYO15A
digenic heterozygosity.

Conclusions:

CELSR1
is a susceptibility gene for familial BAV and HLHS, further implicating planar cell polarity pathway perturbation in congenital heart disease.
Sex Differences in Short-Term and Long-Term Outcomes Among Patients With Acute Ischemic Stroke in China
Authors: Wang Meng , Wang Chun-Juan , Gu Hong-Qiu , Meng Xia , Jiang Yong , Yang Xin , Zhang Jing , Xiong Yun-Yun , Zhao Xing-Quan , Liu Li-Ping , Wang Yi-Long , Wang Yong-Jun , Li Zi-Xiao 
Published: February 2022

Background:
Sex differences in stroke outcomes are crucial to secondary prevention, but previous reports showed inconsistent results. We aimed to explore the sex differences in stroke outcomes in the Third China National Stroke Registry, a prospective multicenter registry study.

Methods:
Among the 15 166 patients enrolled between 2015 and 2018, 9038 patients with acute ischemic stroke (AIS) were included. The primary outcomes were stroke recurrence, mortality, and unfavorable functional outcome (modified Rankin Scale > 2) at 3, 6, and 12 months. Cox regression model was used for stroke recurrence and mortality and logistic regression was used for the unfavorable functional outcome, and adjusted as follows: (1) Model 1: without adjustment; (2) Model 2: adjusted for potential risk factors, National Institutes of Health Stroke Scale at admission, prestroke modified Rankin Scale, tPA (tissue-type plasminogen activator) treatment, TOAST (Trial of ORG 10172 in Acute Stroke Treatment) classification, and onset-to-door time; (3) Model 3: adjusted for covariates from model 2 in addition to blood pressure and blood serum covariates. Multiple imputation was used for missing values, and sensitivity analyses were conducted to describe sex differences by age groups.

Results:

One-third (2802/9038) of the patients were women. Women were significantly older than men (64.78±10.84 versus 61.26±11.42,
P
<0.001). In the fully adjusted model, female patients were more likely to have unfavorable functional outcomes at 3 months (odds ratio, 1.28 [1.09–1.50]), especially among patients aged 65 years or older (odds ratio, 1.39 [1.14–1.70]), but no difference was discovered in patients aged <65 years. There were no sex differences in stroke recurrence and mortality at 3, 6, or 12 months or unfavorable functional outcomes at 6 or 12 months after adjustment.

Conclusions:
Compared with men, women with AIS were less likely to have favorable outcomes at 3 months in China, especially among those over 65 years of age. Experts should aim to tailor secondary prevention strategies for high-risk patients.
Endovascular Therapy Versus Medical Therapy Alone for Basilar Artery Stroke: A Systematic Review and Meta‐Analysis Through Nested Knowledge
Authors: Adusumilli Gautam , Pederson John M. , Hardy Nicole , Kallmes Kevin M. , Hutchison Kristen , Kobeissi Hassan , Heiferman Daniel M. , Kallmes David , Brinjikji Waleed , Albers Gregory W. , Heit Jeremy J. 
Published: February 2022

BackgroundEndovascular thrombectomy (EVT) is an effective treatment for acute ischemic stroke attributable to the anterior circulation large‐vessel occlusion. Randomized trials of patients with posterior circulation large‐vessel occlusion (PC‐LVO) have failed to show a benefit of EVT over medical therapy (MEDT). We performed a systematic review and meta‐analysis to understand better whether EVT is beneficial for PC‐LVO.MethodsUsing the Nested Knowledge AutoLit living review platform, we identified randomized control trials and prospective studies that reported functional outcomes in patients with PC‐LVO treated with EVT versus MEDT. The primary outcome variable was 90‐day modified Rankin scale score of 0 to 3, and secondary outcome variables included 90‐day modified Rankin scale score of 0 to 2, 90‐day mortality, and rate of symptomatic intracranial hemorrhage. A separate random effects model was fit for each outcome measure to calculate pooled odds ratios.ResultsThree studies with 1248 patients, 860 in the EVT arm and 388 in the MEDT arm, were included in the meta‐analysis. The favorable outcome rate (modified Rankin scale score of 0–3) in patients undergoing EVT was 39.9% (95% CI, 30.6%–50.1%) versus 24.5% in patients undergoing MEDT (95% CI, 9.6%–49.8%). Patients undergoing EVT had higher modified Rankin scale score of 0 to 2 rates (31.8% [95% CI, 25.7%–38.5%] versus 19.7% [95% CI, 7.4%–42.7%]) and lower mortality (42.1% [95% CI, 35.9%–48.6%] versus 52.8% [95% CI, 33.3%–71.5%]) compared with patients undergoing MEDT, but neither result was statistically significant. Patients undergoing EVT were more likely to develop symptomatic intracranial hemorrhage (odds ratio, 10.36; 95% CI, 3.92–27.40).ConclusionsEVT treatment of PC‐LVO trended toward superior functional outcomes and reduced mortality compared with MEDT despite a trend toward increased symptomatic intracranial hemorrhage in patients undergoing EVT. Existing randomized and prospective studies are insufficiently powered to demonstrate a benefit of EVT over MEDT in patients with PC‐LVO.