bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peer specialists deliver cognitive behavioral social skills training compared to social skills training and treatment as usual to veterans with serious mental illness: study protocol for a randomized controlled trial
Authors: Mitchell-Miland Chantele , McCarthy Sharon , Chinman Matthew 
Published: May 2022

Abstract
Background
Serious mental illness (SMI) affects 4.6% of the American population. While treatments are available, adherence to specific regimens is often suboptimal. Multiple organizations, such as the Substance Abuse and Mental Health Services Administration (SAMHSA), have called for more options that improve accessibility and engagement to treatment among individuals with SMI. This study protocol answers such calls by testing the effectiveness of peer specialists—individuals with SMI trained to use their experience to help others with SMI—in delivering social skills training (SST) and cognitive behavioral social skills training (CBSST), evidence-based treatments effective at engaging individuals with SMI to make behavioral and cognitive changes. Peer specialists have been shown to be adept at engaging those with SMI in treatment; however, their ability to deliver these structured treatments is unknown.

Methods
This study is a randomized, hybrid 1, research assistant-blinded, superiority trial. A total of 252 veterans with SMI will be recruited and randomized to one of three arms: CBSST-Peer vs. SST-Peer vs. treatment as usual. Participants randomized to CBSST-Peer or SST-Peer will participate in a 20-week group-based intervention that meets weekly for a 60-min class. All participants will complete 4 study assessments at baseline, 10 weeks, 20 weeks, and 32 weeks. A multidimensional battery of functional outcomes will be used with the Independent Living Skills Survey (ILSS) as the primary outcome measure. Post-study completion, veterans who participated in the CBSST-Peer or SST-Peer arms will randomly be invited to participate in focus groups, and peer specialists will complete interviews to further assess the effectiveness of each intervention.

Discussion
Improving care and outcomes for individuals with SMI is a national priority. To improve care, it is imperative to think about new ways to improve engagement and accessibility to care. This study provides an innovative solution to this problem by evaluating how two different types of treatment, delivered by peer specialists, compare to usual care. The results of the study will allow for the expansion of treatment options that improve access and engagement among veterans with SMI.
Effectiveness of a community health worker-delivered care intervention for hypertension control in Uganda: study protocol for a stepped wedge, cluster randomized control trial
Authors: Ingenhoff Rebecca , Nandawula Juliet , Siddharthan Trishul , Ssekitoleko Isaac , Munana Richard , Bodnar Benjamin E. , Weswa Ivan , Kirenga Bruce J. , Mutungi Gerald , van der Giet Markus , Kalyesubula Robert , Knauf Felix 
Published: May 2022

Abstract
Background
Over 80% of the morbidity and mortality related to non-communicable diseases (NCDs) occurs in low-income and middle-income countries (LMICs). Community health workers (CHWs) may improve disease control and medication adherence among patients with NCDs in LMICs, particularly in sub-Saharan African settings. In Uganda, and the majority of LMICs, management of uncontrolled hypertension remains limited in constrained health systems. Intervening at the primary care level, using CHWs to improve medical treatment outcomes has not been well studied. We aim to determine the effectiveness of a CHW-led intervention in blood pressure control among confirmed hypertensive patients and patient-related factors associated with uncontrolled hypertension.

Methods
We will conduct a stepped-wedge cluster randomized controlled trial study of 869 adult patients with hypertension attending two NCD clinics to test the effectiveness, acceptability, and fidelity of a CHW-led intervention. The multi-component intervention will be centered on monthly household visits by trained CHWs for a period of 1 year, consisting of the following: (1) blood pressure and sugar monitoring, (2) BMI monitoring, (3) cardiovascular disease risk assessment, (4) using checklists to guide monitoring and referral to clinics, and (5) healthy lifestyle counseling and education. During home visits, CHWs will remind patients of follow-up visits. We will measure blood pressure at baseline and 3-monthly for the entire cohort. We will conduct individual-level mixed effects analyses of study data, adjusting for time and clustering by patient and community.

Conclusion
The results of this study will inform community delivered HTN management across a range of LMIC settings.

Trial registration
ClinicalTrials.govNCT05068505. Registered on October 6, 2021.
Rapid whole genome sequencing of critically ill pediatric patients from genetically underrepresented populations
Authors: Halabi Nour , Ramaswamy Sathishkumar , El Naofal Maha , Taylor Alan , Yaslam Sawsan , Jain Ruchi , Alfalasi Roudha , Shenbagam Shruti , Bitzan Martin , Yavuz Lemis , Abulhoul Hamda , Shankar Shiva , Janjua Dalwinder , Jadhav Devendrasing , Al Maazmi Munira Mahmoud , Abuhammour Walid , Alsheikh-Ali Alawi , Al Awadhi Mohamed , Al Khayat Abdulla , Abou Tayoun Ahmad N. 
Published: May 2022

AbstractWe describe a case series of five infants (age range: 1–90 days; 4 females and 1 male) who presented to Al Jalila Children’s intensive care units (ICU) with complex multisystem disorders. Patients were Emirati, Kenyan, Jordanian, Filipino, or Pakistani. Trio rapid whole genome sequencing (rWGS) was performed on all five patients and their parents within the hospital’s genomics facility. Results were returned within ~37 h from blood sample draws and were diagnostic in 3 out of 5 patients. Positive findings were a homozygous pathogenic variant in POMT1 gene causing muscular dystrophydystroglycanopathy, a mosaic tetrasomy of the short arm of chromosome 12 (12p13.33p11.1) causing Pallister-Killian syndrome, and compound heterozygous pathogenic variants in the LIPA gene causing lysosomal acid lipase deficiency and Wolman disease. The rWGS analysis provided fast and precise diagnostic findings in those 3 patients and also aided in devising better management plans for them in the intensive care setting. For example, the 3-month-old infant with pathogenic variants in the LIPA gene is now a candidate for an FDA-approved, potentially lifesaving enzyme replacement therapy (sebelipase alfa). Our case series emphasize the feasibility and utility of rWGS in pediatric intensive care setting, in a diverse population that has long been underserved in genomic services. Significant investments in local healthcare infrastructure are needed, globally, for more equitable access of genomic medicine among vulnerable patients.
A holistic approach for severe flexion contracture of bilateral hip, knee, and ankle joints in a neglected patient with prolonged knee–chest positioning on extreme undernourishment: a case report and review of the literature
Authors: Rahyussalim Ahmad Jabir , Zufar Muhammad Luqman Labib , Kurniwati Tri 
Published: May 2022

AbstractBackgroundFlexion contracture in the lower extremity is a common finding in the patient with neuromusculoskeletal disorders. However, severe cases due to prolonged immobilization in knee–chest position are rarely established and remain underreported. This condition is associated with high morbidity and reduced quality of life, especially when it comes to neglected cases with missed injury and late presentation for adequate primary care and rehabilitative program. It remains a difficult challenge to treat, with no established treatment protocol. In addition, other factors related to psychological and socioeconomic conditions may interfere and aggravate the health state of such patients.Case presentationA 19-year-old Javanese man presented with flexion contracture of bilateral hip, knee, and ankle joints due to prolonged immobilization in knee–chest position for almost 2 years following a traffic accident and falling in the bathroom. The condition had persisted for the last 3 years due to irrecoverable condition and lack of awareness. In addition, the patient also presented with paraplegia at level L2–S1, dermatitis neglecta, multiple pressure ulcers, community-acquired pneumonia, and severe malnutrition. Prolonged and sustained passive stretching with serial plastering were performed in the patient. By the time of discharge, patient was able to move and ambulate using wheelchair. Progressive improvement of range of motion and good sitting balance were observed by 3-month follow-up.ConclusionA combination of surgery and rehabilitative care is required in the setting of severe flexion contracture. Passive prolonged stretching showed a better outcome and efficacy in the management of flexion contracture, whether the patient undergoes surgery or not. However, evaluation of residual muscle strength, changes in bone density and characteristic, and the patient’s general and comorbid conditions must always be considered when determining the best treatment of choice for each patient to achieve good outcome and result. A holistic approach with comprehensive assessment is important when treating such patients.
Mutational landscape of chronic myelomonocytic leukemia in Chinese patients
Authors: Nie Yanbo , Shao Liang , Zhang Hong , He Colin K. , Li Hongyu , Zou Junyan , Chen Long , Ji Huaiyue , Tan Hao , Lin Yani , Ru Kun 
Published: May 2022

Abstract
Background
Chronic myelomonocytic leukemia (CMML) is a rare and heterogeneous hematological malignancy. It has been shown that the molecular abnormalities such as ASXL1, TET2, SETBP1, and SRSF2 mutations are common in Caucasian population.

Methods
We retrospectively analyzed 178 Chinese CMML patients. The targeted next generation sequencing (NGS) was used to evaluate 114 gene variations, and the prognostic factors for OS were determined by COX regression analysis.

Results
The CMML patients showed a unique mutational spectrum, including TET2 (36.5%), NRAS (31.5%), ASXL1 (28.7%), SRSF2 (24.7%), and RUNX1 (21.9%). Of the 102 patients with clonal analysis, the ancestral events preferentially occurred in TET2 (18.5%), splicing factors (16.5%), RAS (14.0%), and ASXL1 (7.8%), and the subclonal genes were mainly ASXL1, TET2, and RAS. In addition, the secondary acute myeloid leukemia (sAML) transformed from CMML often had mutations in DNMT3A, ETV6, FLT3, and NPM1, while the primary AML (pAML) demonstrated more mutations in CEBPA, DNMT3A, FLT3, IDH1/2, NPM1, and WT1. It was of note that a series of clones were emerged during the progression from CMML to AML, including DNMT3A, FLT3, and NPM1. By univariate analysis, ASXL1 mutation, intermediate- and high-risk cytogenetic abnormality, CMML-specific prognostic scoring system (CPSS) stratifications (intermediate-2 and high group), and treatment options (best supportive care) predicted for worse OS. Multivariate analysis revealed a similar outcome.

Conclusions
The common mutations in Chinese CMML patients included epigenetic modifiers (TET2 and ASXL1), signaling transduction pathway components (NRAS), and splicing factor (SRSF2). The CMML patients with DNMT3A, ETV6, FLT3, and NPM1 mutations tended to progress to sAML. ASXL1 mutation and therapeutic modalities were independent prognostic factors for CMML.
The GAs Extraction and Analyses system (GAEA) for immediate extraction and measurements of volatiles in the Hayabusa2 sample container
Authors: Miura Yayoi N. , Okazaki Ryuji , Takano Yoshinori , Sakamoto Kanako , Tachibana Shogo , Yamada Keita , Sakai Saburo , Sawada Hirotaka 
Published: May 2022

AbstractHayabusa2 returned surface samples from the C-type near-Earth asteroid (162173) Ryugu to Woomera, South Australia, in December 2020. The samples returned from Ryugu are expected to contain not only volatile components reflecting its primitive nature, but also solar wind components due to exposure to space. Such volatiles may partly be released inside the sealed sample container enclosing Ryugu samples due to particle destruction or container heating in a contingency case. In order to collect and analyze volatiles released in the container prior to the container-opening, we set up a gas extraction and analyses system (GAEA: GAs Extraction and Analyses system). The system requires ultra-high vacuum conditions, small vacuum line volume to minimize dead volume and simple configuration as well as having an interface to connect the container. The system includes gas bottles for passive collection of volatiles at room temperature and bottles for active collection at liquid nitrogen temperature. A quadrupole mass spectrometer is installed to analyze gases in the vacuum line, and a non-evaporative getter pump is also used when noble gases are analyzed. The rehearsal operation of the GAEA was made at ISAS/JAXA as well as transportation tests in Japan. In November 2020, it was transported safely to the Quick Look Facility (QLF) in Woomera. It was set up at the QLF and worked as planned for collection and analysis of gas components from the returned sample container. Here we report the concept, design and calibration results for the GAEA and an outline of analytical protocols applied in Woomera.
Graphical Abstract
Toward accurate seismic flattening: Methods and applications
Authors: Wu Xinming , Li Yaxing , Sawasdee Paphop 
Published: May 2022

Seismic flattening maps a seismic volume from the original space in depth (or two-way traveltime) to the Wheeler domain in geologic time where all of the seismic reflections are horizontally aligned. It provides an efficient way to interpret a whole volume of horizons all at once by extracting the horizontal slices in the flattened space. Conventional slope-based flattening methods that can locally flatten the seismic reflections, however, often fail to flatten the reflections in a global sense and cannot accurately align the reflections across faults. We have developed an iterative method to improve the flattening by using the slopes and correlations of seismic traces. The local slopes, estimated for each image sample, can locally follow reflections but may fail to track the reflections over a long distance or correlate the reflections across faults. The seismic correlations, computed for randomly and sparsely extracted seismic traces, help to align the corresponding reflections over a long distance and across faults. We compute flattening shifts, one for each image sample, by fitting the seismic slopes and correlating in the least-squares sense. We further apply the shifts to relatively adjust the seismic samples in the vertical direction so that all of the reflections are horizontally aligned. We iteratively flatten the seismic volume by repeating the process multiple times (often less than five times). With the flattening shifts, we can compute a relative geologic time (RGT) volume that implicitly contains all the structure information of the seismic volume. An arbitrary number of horizons then can be extracted as isosurfaces of RGT values. Multiple field examples demonstrate that our method significantly improves the flattening, especially across faults and missing data zones, compared with conventional flattening methods. Our method is especially helpful to interpret subtle stratigraphic features (e.g., vertically thin channels) by providing an accurately flattened seismic volume.
Identification and classification of cis-regulatory elements in the amphipod crustacean Parhyale hawaiensis
Authors: Sun Dennis A. , Bredeson Jessen V. , Bruce Heather S. , Patel Nipam H. 
Published: May 2022

ABSTRACT
Emerging research organisms enable the study of biology that cannot be addressed using classical ‘model’ organisms. New data resources can accelerate research in such animals. Here, we present new functional genomic resources for the amphipod crustacean Parhyale hawaiensis, facilitating the exploration of gene regulatory evolution using this emerging research organism. We use Omni-ATAC-seq to identify accessible chromatin genome-wide across a broad time course of Parhyale embryonic development. This time course encompasses many major morphological events, including segmentation, body regionalization, gut morphogenesis and limb development. In addition, we use short- and long-read RNA-seq to generate an improved Parhyale genome annotation, enabling deeper classification of identified regulatory elements. We discover differential accessibility, predict nucleosome positioning, infer transcription factor binding, cluster peaks based on accessibility dynamics, classify biological functions and correlate gene expression with accessibility. Using a Minos transposase reporter system, we demonstrate the potential to identify novel regulatory elements using this approach. This work provides a platform for the identification of novel developmental regulatory elements in Parhyale, and offers a framework for performing such experiments in other emerging research organisms.
METASTATIC LESION OF THE BRAIN. DIAGNOSIS AND TREATMENT
Authors: Bobkov M. 
Published: May 2022

The article provides an overview of the current literature on the diagnosis and treatment of second-ary (metastatic) damage to the brain substance.
Over the past years, Russia has seen a high incidence of malignant neoplasms, with a clearly observed upward trend. In 2019, this figure was 376.3 per 100,000 population compared to 369.6 per 100,000 population in 2018 and 293.7 per 100,000 population in 2000. However, thanks to modern methods of diagnosis and treatment, the life span of patients suffering from malignant neo-plasms is significantly increased, and, as a result, the chance of “surviving” before the onset of a metastatic lesion of the brain substance increases. Today, this formidable complication of the tumor process occurs in approximately 8-10% of cancer patients, while in most of them they are symptomatic. In some nosological forms of malig-nant neoplasms (small cell lung cancer, melanoma), the frequency of brain metastasis can reach 80% or more.
The effect of dust particles on the wettability of some native plants in Zagros Mountains, Iran
Authors: Yasuri Amir Karimdoost 
Published: May 2022

In recent years, in addition to pollution from cars, factories and other polluting devices, the country of Iran has been the destination of dust that have entered from Iraq and Saudi Arabia and caused pollution of the climate. In this research, the wettability of some native plants in Zagros Mountains has been investigated experimentally by measuring the contact angle. Sampling of oak trees of Quercus brantii Lindl. species was carried out around Khorramabad city, Nozhian waterfall, Chegheni city, and recreation area of Shoorab forest park. Forty samples of oak leaves, red mulberries of Morus rubra L. species and white mulberries of Morus alba L. species were randomly selected and the contact angle of the water drop on them was measured using a contact angle goniometer and also separately measured by Image J software. Under the influence of the dust, it was observed that the contact angle of the leaf area was completely eliminated, but the contact angle of the abaxial leaf surface had not changed; this change in the contact angle seem to be due to the loss of acylic cyst of the oak leaf caused by the disruption of the photosynthesis operation. Oak trees absorb contaminants. This problem eliminates leaf pores and dry leaves. Also, results show that the oak leaves are hydrophobic and have good resistance to drought. However, the presence of a lot of dust causes water droplets to spread completely on the oak leaves, thus reducing watering to the roots. As a result, dust reduces the resistance and resilience of oak trees against drought. Present study is very important for protection and monitoring of forest health and prevention of the reduction of plant species diversity.
Determinants of the Engagement of Virtual Runs’ Participants in the Co-creation of Customer Value during the Pandemic
Authors: Waśkowski Zygmunt , Jasiulewicz Anna 
Published: May 2022

The study focuses on the research question of the determinants and motivating factors which stimulate consumers to engage in the co-creation of customer value, even though the product they are offered is merely a substitute for the one they are used to. The research focuses on the virtual runs and its subject are the runners participating in the Białystok Virtual Half-Marathon. There are two equivalent objectives of the study: (a) the identification and the assessment of the determinants of the runners’ engagement, and (b) the segmentation of the virtual run participants on the basis of the diagnosed determinants of their involvement.
The article is based on the results of the survey conducted in 2020 on a sample of 419 runners, by means of the CAWI method. The respondents were asked to assess 17 factors related to the customer engagement in the co-creation of value, with reference to the virtual run in which they participated. The Białystok Virtual Half-Marathon, the second biggest virtual run organised in 2020 in Poland, was used as a point of reference for this survey. This run was an alternative proposal prepared by the organiser in response to the Covid-19 pandemic and the ban on the organisation of real runs in the whole country.
The research findings allowed for expanding the theoretical knowledge of the concept of the customer value co-creation and the consumers’ engagement in this process. The research resulted in distinguishing four meta-factors determining the runners’ engagement and establishing the strength of their influence on the customer value co-creation. The research also revealed the runners’ motivation for participating in the virtual run. The runners’ involvement was determined by the hedonistic and social factors, though the structure and the strength of their impact varied in relation to the respondents’ demographics. All in all, four segments of runners were distinguished.
Short- and long-term effects of transfers on football clubs' sport performance
Authors: Wanat Tomasz , Leksowski Łukasz 
Published: May 2022

One of the important elements of football club quality management is the sale and purchase of player’s cards. These activities have important implications for the financial and sport performance of football clubs. The purpose of this paper is to determine how players transfers affect football teams’ sport performance. Data on transfers and sport performance came from available databases. They covered the period from 2004/05 to 2018/19 (before the pandemic). For data analysis, a series of hierarchical analysis of regression were conducted. The results show that there is an effect of transfers on football teams’ sport performance but it explains a relatively small amount of football club’s sport performance. The impact from a transfer in a given year affects sport performance not only in the same year, but also in subsequent years. However, the effect of transfer disappears when control variables are introduced. Thus, the general conclusion from the study is that there is no overall effect of transfers on teams’ sport performance. The analyses were conducted only on clubs from the 5 major European leagues and football clubs that were continuously present in the top division. Due to the fact that it included mainly the strongest clubs, the results are relevant for clubs wishing to build up their sporting position on the European market. It is less relevant for weaker clubs. The study consisted of using data over a period of several years, which provides an opportunity to trace the dynamics of change and long-term effects, which is rarely analyzed in the sports literature.