bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical study applying machine learning to detect a rare disease: results and lessons learned
Authors: Hersh William R , Cohen Aaron M , Nguyen Michelle M , Bensching Katherine L , Deloughery Thomas G 
Published: June 2022

Abstract
Machine learning has the potential to improve identification of patients for appropriate diagnostic testing and treatment, including those who have rare diseases for which effective treatments are available, such as acute hepatic porphyria (AHP). We trained a machine learning model on 205 571 complete electronic health records from a single medical center based on 30 known cases to identify 22 patients with classic symptoms of AHP that had neither been diagnosed nor tested for AHP. We offered urine porphobilinogen testing to these patients via their clinicians. Of the 7 who agreed to testing, none were positive for AHP. We explore the reasons for this and provide lessons learned for further work evaluating machine learning to detect AHP and other rare diseases.
Wealth in People and Places: Understanding Transnational Gift Obligations
Authors: Appau Samuelson , Crockett David 
Published: June 2022

AbstractIn some cultures, migrants bear an obligation to bring gifts from the foreign country for their relations when returning to their homeland. Why, and to what end? We examine the reasons for these transnational gift obligations in a multisite study of Ghanaian migrants in the United States and Australia, as well as people in Ghana with migrant relations living overseas. We adopt a wealth-centered perspective that problematizes the underexplored mutual impact of migrants and their gifts on social hierarchies within societies and transnational spatial hierarchies between societies. We show how the concepts of wealth in people and wealth in place connect with local gift economies to explain transnational gifting obligations. Specifically, informants use transnational gifts that embody wealth in place to acknowledge “being wealth” to people and to acquire wealth in others. We highlight the wealth in things that are exchanged as gift objects and the wealth in people who are exchanged as gift subjects between here and there. Our findings implicate a “glocal” gift economy that results from the global flows of things and people as gifts within transnational places of differing statuses. We discuss how this glocal gift economy (re)produces transnational spatial hierarchies and local (national) status hierarchies.
On or Off Track: How (Broken) Streaks Affect Consumer Decisions
Authors: Silverman Jackie , Barasch Alixandra 
Published: June 2022

AbstractNew technologies increasingly enable consumers to track their behaviors over time, making them more aware of their “streaks”—behaviors performed consecutively three or more times—than ever before. Our research explores how these logged streaks affect consumers’ decisions to engage in the same behavior subsequently. In seven studies, we find that intact streaks highlighted via behavioral logs increase consumers’ subsequent engagement in that behavior, relative to when broken streaks are highlighted. Importantly, this effect is independent of actual past behavior and depends solely on how that behavior is represented within the log. This is because consumers consider maintaining a logged streak to be a meaningful goal in and of itself. In line with this theory, the effect of intact (vs. broken) logged streaks is amplified when consumers attribute a break in the streak to themselves rather than to external factors, and attenuated when consumers can “repair” a broken streak. Our research provides actionable insights for companies seeking to benefit from highlighting consumers’ streaks in various consequential domains (e.g., fitness, learning) without incurring a cost (e.g., reduced engagement or abandonment) when those streaks are broken.
Living With the Flu: Public Health and Civic Life During the Spanish Influenza Pandemic of 1918
Authors: Dicke Tom 
Published: June 2022

Abstract
Most studies of how United States cities responded to the first deadly wave of Spanish influenza focus on the ways public health officials and their allies reacted to the crisis. This study expands our understanding of the pandemic by focusing on how members of the public responded to those efforts to contain the flu. It does so through a close look at social and civil life in a small city in the southern Midwest during the thirty-two days the flu was epidemic there. Shifting the focus in this way brings previously obscured gaps in the public health response into the light. Specifically, this study finds that while compliance in most areas was high there were two places where it was low: activities in support of American involvement in the European War, and participation in social or civic activities. From the first day of the epidemic to the last the society pages of the local newspapers reported a stream of activities that clearly violated emergency measures. Despite the ban on public gatherings, social clubs, fraternal societies, and civic groups all regularly met. The local college football team practiced, and people continued to turn out for weddings, funerals, birthday parties, dinner parties, and extended visits from out-of-town friends and family. With one possible exception, none of the social or civic activities were carried out as protests against health regulations. Instead local newspapers reported these activities as items of social interest.
Patterns of labral tears and cartilage injury are different in femoroacetabular impingement and dysplasia
Authors: Cho Yoon-Je , Rhyu Kee-Hyung , Chun Young-Soo , Kim Myung-Seo 
Published: June 2022

ABSTRACT
The aim of this study was to assess injury patterns and risk factors of the acetabular labrum and associated cartilage in patients with femoroacetabular impingement (FAI) versus dysplasia. We retrospectively reviewed 137 patients diagnosed with labral tears and FAI or dysplasia (74 or 63 cases, respectively) through an arthroscopic procedure. Labral and concomitant cartilage injuries were evaluated. Demographics and radiological variables [lateral center-edge angle (LCEA), anterior center-edge angle, acetabular index (AI), acetabular version and alpha angle] were evaluated as risk factors for labral and cartilage injuries. Detachment of acetabular cartilage with intact labro-cartilaginous junction was the most common in dysplasia, whereas cartilage delamination from the labro-cartilaginous junction was more common in FAI (P &lt; 0.001). A higher body mass index was significantly associated with delamination injury in FAI (odds ratio 1.226; 95% CI 1.043–1.441; P = 0.013). A significant correlation was evident between detachment injury and a larger AI in dysplasia (odds ratio 1.127; 95% CI 1.000–1.270; P = 0.049). In addition, symptom duration was positively correlated with the extent of labral tearing in FAI (P = 0.013), whereas the smaller LCEA was correlated with the larger extent of labral tearing in dysplasia (P = 0.044). FAI and dysplasia patients exhibited different labral and cartilage injury patterns. Increased body mass index was correlated with delamination injury in FAI, whereas an increased AI was associated with detachment injury in dysplasia. Greater tearing was associated with a longer symptom duration in FAI, and a decreased LCEA was a risk factor for the extent of tearing in dysplasia.
Level of evidence
Level III. Case–control study.
Geographies of Shame: Diachronic and Transnational Shame in Forced Migrants with Experiences of Sexual and Gender-Based Violence
Authors: Papoutsi Anna , Phillimore Jenny , Akyüz Selin , Bradby Hannah , Goodson Lisa , Vaughan Cathy 
Published: June 2022

AbstractThis article investigates the shame that forced migrants bear because of experiences of sexual and gender-based violence (SGBV). Using data from the UK, Turkey, Sweden, and Australia, we focus on shame experienced by women and LGBTQIA+ forced migrants throughout their journey, across borders and cultures. We propose three key ways to understand the complexities of shame from an experiential, temporal, and spatial perspective. First, we discuss how shame, often relating to family honour and stemming from survivors’ experiences in their home country, travels with them over time and space. We then move on to illustrate how prolonged and/or delayed feelings of shame impact on survivors’ self-confidence, self-worth, and trust in people and institutions. Finally, we consider the specific challenges LGBTQIA+ individuals face and how shame affected their settlement prospects. We argue that the SGBV experiences of forced migrants and the associated shame transcend time and space, forming landscapes of transnational and diachronic shame. Our analysis underlines the need for gender and sexuality-sensitive services for forced migrants in countries of refuge, which take into account potential ongoing effects of experiences of violence.
Perioperative management of a patient with a giant thyroglossal duct cyst: a case report
Authors: Iwasa Yoh-ichiro , Hori Kentaro , Hiramatsu Ken , Yokota Yoh , Kitano Tomohiro , Kitoh Ryosuke , Takumi Yutaka 
Published: June 2022

Abstract
Thyroglossal duct cysts (TGDC) are the most common type of congenital neck masses, which generally present in young adults. We present a rare case of a giant TGDC in a 77-year-old patient who required atypical perioperative management. The patient presented with a large soft mass on his anterior neck. Computed tomography showed a lobulated cystic mass measuring 18 × 16 cm, extending from the tongue base to the inferior level of the clavicle. Because difficult intubation was expected, the cyst was punctured and most of the fluid was drained prior to surgery. The swelling of the tongue base was remarkably reduced, and intubation was performed safely. The cyst was extracted using the Sistrunk procedure and tracheotomy was performed. Histopathological examination confirmed the diagnosis of TGDC. Preoperative volume reduction of the cyst and tracheotomy should be considered for oral intubation and postoperative airway management, respectively, in patients with large TGDC.
N-terminal modifications, the associated processing machinery, and their evolution in plastid-containing organisms
Authors: Meinnel Thierry , Giglione Carmela 
Published: June 2022

AbstractThe N-terminus is a frequent site of protein modifications. Referring primarily to knowledge gained from land plants, here we review the modifications that change protein N-terminal residues and provide updated information about the associated machinery, including that in Archaeplastida. These N-terminal modifications include many proteolytic events as well as small group additions such as acylation or arginylation and oxidation. Compared with that of the mitochondrion, the plastid-dedicated N-terminal modification landscape is far more complex. In parallel, we extend this review to plastid-containing Chromalveolata including Stramenopiles, Apicomplexa, and Rhizaria. We report a well-conserved machinery, especially in the plastid. Consideration of the two most abundant proteins on Earth—Rubisco and actin—reveals the complexity of N-terminal modification processes. The progressive gene transfer from the plastid to the nuclear genome during evolution is exemplified by the N-terminus modification machinery, which appears to be one of the latest to have been transferred to the nuclear genome together with crucial major photosynthetic landmarks. This is evidenced by the greater number of plastid genes in Paulinellidae and red algae, the most recent and fossil recipients of primary endosymbiosis.
Integrating a crop growth model and radiative transfer model to improve estimation of crop traits based on deep learning
Authors: Chen Qiaomin , Zheng Bangyou , Chen Tong , Chapman Scott C 
Published: June 2022

Abstract
A major challenge for the estimation of crop traits (biophysical variables) from canopy reflectance is the creation of a high-quality training dataset. To address this problem, this research investigated a conceptual framework by integrating a crop growth model with a radiative transfer model to introduce biological constraints in a synthetic training dataset. In addition to the comparison of two datasets without and with biological constraints, we also investigated the effects of observation geometry, retrieval method, and wavelength range on estimation accuracy of four crop traits (leaf area index, leaf chlorophyll content, leaf dry matter, and leaf water content) of wheat. The theoretical analysis demonstrated potential advantages of adding biological constraints in synthetic training datasets as well as the capability of deep learning. Additionally, the predictive models were validated on real unmanned aerial vehicle-based multispectral images collected from wheat plots contrasting in canopy structure. The predictive model trained over a synthetic dataset with biological constraints enabled the prediction of leaf water content from using wavelengths in the visible to near infrared range based on the correlations between crop traits. Our findings presented the potential of the proposed conceptual framework in simultaneously retrieving multiple crop traits from canopy reflectance for applications in precision agriculture and plant breeding.
Ageing meets kidney disease
Authors: Ortiz Alberto , Mattace-Raso Francesco , Soler Maria José , Fouque Denis 
Published: June 2022

ABSTRACTChronic kidney disease (CKD) is defined as abnormalities of kidney structure or function, present for ˃3 months, with implications for health. The most used diagnostic criteria are a urinary albumin: creatinine ratio ≥30 mg/g or an estimated glomerular filtration rate (eGFR) &lt;60 mL/min/1.73 m2. Either of these diagnostic thresholds is associated with adverse health outcomes. GFR decreases with age and the prevalence of CKD is highest in older adults; moreover, the presence of CKD is associated with an increased risk of all-cause and cardiovascular death related to accelerated ageing in all age ranges, and the absolute increase in risk is highest for those aged ˃75 years. Indeed, premature death is a more common outcome than CKD progression to kidney failure requiring kidney replacement therapy. The progressive ageing of the world population contributes to the projection that CKD will become the second most common cause of death before the end of the century in countries with long life expectancy. The current collection of selected studies on kidney disease and ageing published in Age&Ageing, NDT and CKJ provides an overview of key topics, including cognitive decline, sarcopaenia, wasting and cardiovascular and non-cardiovascular morbidity and mortality, the management of kidney failure and gender differences in CKD progression.
Role of chronotype in dietary intake, meal timing, and obesity: a systematic review
Authors: Teixeira Gabriela P , Guimarães Kisian C , Soares Ana Gabriela N S , Marqueze Elaine C , Moreno Cláudia R C , Mota Maria C , Crispim Cibele A 
Published: June 2022

Abstract

Context
Recent studies show that dietary habits and obesity seem to be influenced by chronotype, which reflects an individual’s preference for the timing of sleeping, eating, and activity in a 24-hour period.

Objective
This review aimed to analyze the association of chronotype with dietary habits, namely energy and macronutrient intakes, meal timing, and eating patterns, as well as with obesity.

Data Sources
PubMed/MEDLINE, LILACS, and Google Scholar databases were searched between 2004 and 2020. Study selection was performed by 2 authors independently; disagreements on eligibility of articles were resolved by a third author. After assessment of 12 060 abstracts, 43 studies (21 articles on obesity; 13 on food consumption, meal timing, and eating patterns; and 9 that addressed both obesity and dietary behavior) were included.

Data Extraction
A standard form was used to extract study design, country, number of participants, method of chronotype determination, and main findings.

Data Analysis
Approximately 95% of included studies showed an association between eveningness and at least 1 unhealthy eating habit. Morningness was associated with regular consumption of fresh and minimally processed foods. In addition, about 47% of studies showed a higher association between late types and obesity.

Conclusion
Late types are more likely to present unhealthy eating habits, such as eating late at night, skipping breakfast often, and eating processed/ultraprocessed foods, while early types are more likely to have healthy and protective habits, such as eating early and eating predominantly fresh/minimally processed foods. Intermediate types tend to have a pattern of health and eating more similar to early types than to late types. Late types are also more likely to present higher weight and body mass index than early or intermediate types.

Systematic Review Registration
PROSPERO registration no. CRD42021256078.
Do Members of Parliament Express More Opposition in the Plenary than in the Committee? Comparing Frontstage and Backstage Behaviour in Five National Parliaments
Authors: Karlsson Christer , Persson Thomas , Mårtensson Moa 
Published: June 2022

Abstract
This study attempts to break new ground by systematically comparing oppositional behaviour of Members of Parliament (MPs) in the two key arenas found in parliament: the plenary and the committee. Do MPs express more opposition frontstage in the plenary than backstage in the committee when discussing European affairs? The article sheds new light on political opposition in parliament by using a dataset of hand-coded statements made by MPs during plenary debates and European Affairs committee deliberations in five national parliaments. The results lend strong support to the main hypothesis that MPs express more opposition during plenary debates than committee deliberations.
Epigenetic Mutation in a Tubulin-Folding Cofactor B (ZmTFCB) Gene Arrests Kernel Development in Maize
Authors: Guo Yingmei , Chen Yan , Zhang Jie , Li Jiankun , Fan Kaijian , Chen Rongrong , Liu Yunjun , Zheng Jun , Fu Junjie , Gu Riliang , Wang Guoying , Cui Yu , Du Xuemei , Wang Jianhua 
Published: June 2022

Abstract
Epialleles, the heritable epigenetic variants that are not caused by changes in DNA sequences, can broaden genetic and phenotypic diversity and benefit to crop breeding, but very few epialleles related to agricultural traits have been identified in maize. Here, we cloned a small kernel mutant, smk-wl10, from maize, which encoded a tubulin-folding cofactor B (ZmTFCB) protein. Expression of the ZmTFCB gene decreased in the smk-wl10 mutant, which arrested embryo, endosperm and basal endosperm transfer layer developments. Overexpression of ZmTFCB could complement the defective phenotype of smk-wl10. No nucleotide sequence variation in ZmTFCB could be found between smk-wl10 and wild type (WT). Instead, we detected hypermethylation of nucleotide CHG (where H is A, C or T nucleotide) sequence contexts and increased level of histone H3K9me2 methylation in the upstream sequence of ZmTFCB in smk-wl10 compared with WT, which might respond to the attenuating transcription of ZmTFCB. In addition, yeast two-hybrid and bimolecular fluorescence complementation assays identified a strong interaction between ZmTFCB and its homolog ZmTFCE. Thus, our work identifies a novel epiallele of the maize ZmTFCB gene, which might represent a common phenomenon in the epigenetic regulation of important traits such as kernel development in maize.
Two novel mouse models of slow-wave-sleep enhancement in aging and Alzheimer’s disease
Authors: Ogbeide-Latario Oghomwen E , Ferrari Loris L , Gompf Heinrich S , Anaclet Christelle 
Published: June 2022

AbstractAging and Alzheimer’s disease (AD) are both associated with reduced quantity and quality of the deepest stage of sleep, called slow-wave-sleep (SWS). Slow-wave-sleep deficits have been shown to worsen AD symptoms and prevent healthy aging. However, the mechanism remains poorly understood due to the lack of animal models in which SWS can be specifically manipulated. Notably, a mouse model of SWS enhancement has been recently developed in adult mice. As a prelude to studies assessing the impact of SWS enhancement on aging and neurodegeneration, we first asked whether SWS can be enhanced in animal models of aging and AD.The chemogenetic receptor hM3Dq was conditionally expressed in GABAergic neurons of the parafacial zone of aged mice and AD (APP/PS1) mouse model. Sleep–wake phenotypes were analyzed in baseline condition and following clozapine-N-oxide (CNO) and vehicle injections. Both aged and AD mice display deficits in sleep quality, characterized by decreased slow wave activity. Both aged and AD mice show SWS enhancement following CNO injection, characterized by a shorter SWS latency, increased SWS amount and consolidation, and enhanced slow wave activity, compared with vehicle injection. Importantly, the SWS enhancement phenotypes in aged and APP/PS1 model mice are comparable to those seen in adult and littermate wild-type mice, respectively. These mouse models will allow investigation of the role of SWS in aging and AD, using, for the first time, gain-of SWS experiments.
β-Arrestin 2 and Epac2 Cooperatively Mediate DRD1-Stimulated Proliferation of Human Neural Stem Cells and Growth of Human Cerebral Organoids
Authors: Dong Xiaoxu , Chen Yujie , Lu Juan , Huang Shichao , Pei Gang 
Published: June 2022

Abstract
G-protein-coupled receptors (GPCRs) reportedly relay specific signals, such as dopamine and serotonin, to regulate neurogenic processes although the underlying signaling pathways are not fully elucidated. Based on our previous work, which demonstrated dopamine receptor D1 (DRD1) effectively induces the proliferation of human neural stem cells, here we continued to show the knockout of β-arrestin 2 by CRISPR/Cas9 technology significantly weakened the DRD1-induced proliferation and neurosphere growth. Furthermore, inhibition of the downstream p38 MAPK by its specific inhibitors or small hairpin RNA mimicked the weakening effect of β-arrestin 2 knockout. In addition, blocking of Epac2, a PKA independent signal pathway, by its specific inhibitors or small hairpin RNA also significantly reduced DRD1-induced effects. Simultaneous inhibition of β-arrestin 2/p38 MAPK and Epac2 pathways nearly abolished the DRD1-stimulated neurogenesis, indicating the cooperative contribution of both pathways. Consistently, the expansion and folding of human cerebral organoids as stimulated by DRD1 were also mediated cooperatively by both β-arrestin 2/p38 MAPK and Epac2 pathways. Taken together, our results reveal that GPCRs apply at least 2 different signal pathways to regulate neurogenic processes in a delicate and balanced manners.