bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post COVID-19 irritable bowel syndrome
Authors: Marasco Giovanni , Cremon Cesare , Barbaro Maria Raffaella , Cacciari Giulia , Falangone Francesca , Kagramanova Anna , Bordin Dmitry , Drug Vasile , Miftode Egidia , Fusaroli Pietro , Mohamed Salem Youssef , Ricci Chiara , Bellini Massimo , Rahman Mohammed Masudur , Melcarne Luigi , Santos Javier , Lobo Beatriz , Bor Serhat , Yapali Suna , Akyol Deniz , Sapmaz Ferdane Pirincci , Urun Yonca Yilmaz , Eskazan Tugce , Celebi Altay , Kacmaz Huseyin , Ebik Berat , Binicier Hatice Cilem , Bugdayci Mehmet Sait , Yağcı Munkhtsetseg Banzragch , Pullukcu Husnu , Kaya Berrin Yalınbas , Tureyen Ali , Hatemi İbrahim , Koc Elif Sitre , Sirin Goktug , Calıskan Ali Riza , Bengi Goksel , Alıs Esra Ergun , Lukic Snezana , Trajkovska Meri , Hod Keren , Dumitrascu Dan , Pietrangelo Antonello , Corradini Elena , Simren Magnus , Sjölund Jessica , Tornkvist Navkiran , Ghoshal Uday C , Kolokolnikova Olga , Colecchia Antonio , Serra Jordi , Maconi Giovanni , De Giorgio Roberto , Danese Silvio , Portincasa Piero , Di Sabatino Antonio , Maggio Marcello , Philippou Elena , Lee Yeong Yeh , Salvi Daniele , Venturi Alessandro , Borghi Claudio , Zoli Marco , Gionchetti Paolo , Viale Pierluigi , Stanghellini Vincenzo , Barbara Giovanni 
Published: December 2022

ObjectivesThe long-term consequences of COVID-19 infection on the gastrointestinal tract remain unclear. Here, we aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut–brain interaction after hospitalisation for SARS-CoV-2 infection.DesignGI-COVID-19 is a prospective, multicentre, controlled study. Patients with and without COVID-19 diagnosis were evaluated on hospital admission and after 1, 6 and 12 months post hospitalisation. Gastrointestinal symptoms, anxiety and depression were assessed using validated questionnaires.ResultsThe study included 2183 hospitalised patients. The primary analysis included a total of 883 patients (614 patients with COVID-19 and 269 controls) due to the exclusion of patients with pre-existing gastrointestinal symptoms and/or surgery. At enrolment, gastrointestinal symptoms were more frequent among patients with COVID-19 than in the control group (59.3% vs 39.7%, p<0.001). At the 12-month follow-up, constipation and hard stools were significantly more prevalent in controls than in patients with COVID-19 (16% vs 9.6%, p=0.019 and 17.7% vs 10.9%, p=0.011, respectively). Compared with controls, patients with COVID-19 reported higher rates of irritable bowel syndrome (IBS) according to Rome IV criteria: 0.5% versus 3.2%, p=0.045. Factors significantly associated with IBS diagnosis included history of allergies, chronic intake of proton pump inhibitors and presence of dyspnoea. At the 6-month follow-up, the rate of patients with COVID-19 fulfilling the criteria for depression was higher than among controls.ConclusionCompared with controls, hospitalised patients with COVID-19 had fewer problems of constipation and hard stools at 12 months after acute infection. Patients with COVID-19 had significantly higher rates of IBS than controls.Trial registration numberNCT04691895.
Loneliness at the age of COVID-19
Authors: Lederman Zohar 
Published: December 2022

Loneliness has been a major concern for philosophers, poets and psychologists for centuries. In the past several decades, it has concerned clinicians and public health practitioners as well. The research on loneliness is urgent for several reasons. First, loneliness has been and still is extremely ubiquitous, potentially affecting people across multiple demographics and geographical areas. Second, it is philosophically intriguing, and its analysis delves into different branches of philosophy including phenomenology, existentialism, philosophy of mind, etc. Third, empirical research has shown that loneliness is a significant health risk factor. Loneliness may thus be defined as a (negative) social determinant of health.Having that said, COVID-19 has demonstrated how little we as members of humanity have been prepared to face the loneliness resulting from the global response to the virus. As people worldwide are literally dying from loneliness, we still do not know what makes one feel lonely while making another feel being in solitude, or how is it that one feels lonely in the heart of London.In this essay, I first review loneliness in general and specifically in the context of COVID-19. I then argue that loneliness should be understood as a social determinant of health. Lastly, I argue that individuals have a right not to be lonely. Such right stems in turn from the right to healthcare or even a right to health.
Mechanistic approach to the antioxidant activities of metal-associated superoxide with Trolox
Authors: Singh Bula , Das Ranendu Sekhar 
Published: December 2022

Trolox-C (TXC) is a water-soluble analogue of α-tocopherol that reduces the metal-bound superoxo complex (SOC), [(NH3)5Co(µ-O2)Co(NH3)5]5+in water–ethanol media. In aqueous-acid media ([H+] = 0.02–0.70 mol/L), TXC quantitatively reduces SOC under the pseudo first-order reaction condition where the concentration of TXC, [TXC], was at least 10 times or more than that of [SOC]. Variations in media ionic strength suggest for the reaction between two cationic species, and a positive kinetic isotope effect ( kH/ kD < 1) indicates for a pre-equilibrium step of protonation of the pyran-oxygen of TXC. Both TXC and the protonated TXC, i.e., TXCH, are the potential reductants under the experimental range of media acidity. The reduction of SOC takes place through the single-electron transfer and the kinetic analysis yields the value for second-order rate constants for TXC and TXCH as 9.7 and 3.6 × 103 (mol/L)−1s−1at 15 °C.
Ontogeny ofEuphanerops longaevusfrom the Upper Devonian Miguasha Fossil–Fish–Lagerstätte and comparison with the skeletogenesis of the sea lampreyPetromyzon marinus
Authors: Chevrinais Marion , Morel Catherine , Renaud Claude B. , Cloutier Richard 
Published: December 2022

Ontogeny is of paramount importance to understand evolutionary relationships of organisms. However, in the fossil record, early developmental stages are rarely preserved because of their unmineralized skeleton. Here, we describe the ontogeny of the Devonian jawless fish, Euphanerops longaevus, based on observations from more than 3500 specimens. The ontogeny of Euphanerops is compared with the development of the median fins of the extant jawless fish, the sea lamprey ( Petromyzon marinus). From a subsample of 216 specimens of Euphanerops, we define three ontogenetic stages: larvae (2–38 mm total length (TL), mostly composed of “ Scaumenella mesacanthi”), juveniles (28–98 mm TL), and adults (≥90 mm TL) based on the degree of skeletal development, chemical and microscopic compositions. Larvae display three cranial plates, a simple branchial apparatus, notochordal elements, and caudal fin supports. In juveniles, we document the development of paired anteroventral, anal, and median dorsal fins. Given how little information is generally available on ostracoderm ontogeny, the growth series of Euphanerops provides an unparalleled opportunity to understand the development of early vertebrate characters.
$$^{74}$$Ge($$n,\gamma $$) cross section below 70 keV measured at n_TOF CERN
Authors: Lederer-Woods C. , Aberle O. , Andrzejewski J. , Audouin L. , Bécares V. , Bacak M. , Balibrea J. , Barbagallo M. , Barros S. , Battino U. , Bečvář F. , Beinrucker C. , Berthoumieux E. , Billowes J. , Bosnar D. , Brugger M. , Caamaño M. , Calviño F. , Calviani M. , Cano-Ott D. , Cardella R. , Casanovas A. , Castelluccio D. M. , Cerutti F. , Chen Y. H. , Chiaveri E. , Colonna N. , Cortés G. , Cortés-Giraldo M. A. , Cosentino L. , Damone L. A. , Diakaki M. , Domingo-Pardo C. , Dressler R. , Dupont E. , Durán I. , Fernández-Domínguez B. , Ferrari A. , Ferreira P. , Finocchiaro P. , Furman V. , Göbel K. , García A. R. , Gawlik-Ramięga A. , Glodariu T. , Gonçalves I. F. , González-Romero E. , Goverdovski A. , Griesmayer E. , Guerrero C. , Gunsing F. , Harada H. , Heftrich T. , Heinitz S. , Heyse J. , Jenkins D. G. , Jericha E. , Käppeler F. , Kadi Y. , Katabuchi T. , Kavrigin P. , Ketlerov V. , Khryachkov V. , Kimura A. , Kivel N. , Kokkoris M. , Krtička M. , Leal-Cidoncha E. , Leeb H. , Lerendegui-Marco J. , Meo S. Lo , Lonsdale S. J. , Losito R. , Macina D. , Marganiec J. , Martínez T. , Massimi C. , Mastinu P. , Mastromarco M. , Matteucci F. , Maugeri E. A. , Mendoza E. , Mengoni A. , Milazzo P. M. , Mingrone F. , Mirea M. , Montesano S. , Musumarra A. , Nolte R. , Oprea A. , Patronis N. , Pavlik A. , Perkowski J. , Porras I. , Praena J. , Quesada J. M. , Rajeev K. , Rauscher T. , Reifarth R. , Riego-Perez A. , Rout P. C. , Rubbia C. , Ryan J. A. , Sabaté-Gilarte M. , Saxena A. , Schillebeeckx P. , Schmidt S. , Schumann D. , Sedyshev P. , Smith A. G. , Stamatopoulos A. , Tagliente G. , Tain J. L. , Tarifeño-Saldivia A. , Tassan-Got L. , Tsinganis A. , Valenta S. , Vannini G. , Variale V. , Vaz P. , Ventura A. , Vlachoudis V. , Vlastou R. , Wallner A. , Warren S. , Weigand M. , Weiss C. , Wolf C. , Woods P. J. , Wright T. , Žugec P. ,   n_TOF Collaboration
Published: December 2022

AbstractNeutron capture reaction cross sections on$$^{74}$$74Ge are of importance to determine$$^{74}$$74Ge production during the astrophysical slow neutron capture process. We present new resonance data on$$^{74}$$74Ge($$n,\gamma $$n,γ) reactions below 70 keV neutron energy. We calculate Maxwellian averaged cross sections, combining our data below 70 keV with evaluated cross sections at higher neutron energies. Our stellar cross sections are in agreement with a previous activation measurement performed at Forschungszentrum Karlsruhe by Marganiec et al., once their data has been re-normalised to account for an update in the reference cross section used in that experiment.
Tetraquark mixing supported by the partial decay widths of two light-meson nonets
Authors: Kim Hungchong , Kim K. S. 
Published: December 2022

AbstractRecently, the tetraquark mixing framework has been proposed as a possible structure for the two light-meson nonets in the $$J^P=0^+$$

J
P

=

0
+

channel, the light nonet composed of $$a_0(980)$$

a
0

(
980
)

, $$K_0^*(700)$$

K
0
∗

(
700
)

, $$f_0(500)$$

f
0

(
500
)

, $$f_0(980)$$

f
0

(
980
)

, and the heavy nonet of $$a_0(1450)$$

a
0

(
1450
)

, $$K_0^*(1430)$$

K
0
∗

(
1430
)

, $$f_0(1370)$$

f
0

(
1370
)

, $$f_0(1500)$$

f
0

(
1500
)

. Among various signatures, we report in this work that their partial decay widths collected from various experimental data in Particle Data Group (PDG) can support this mixing scheme also. In particular, we demonstrate that the couplings of the light nonet to two pseudoscalar mesons estimated from the partial widths are consistently stronger than those of the heavy nonet. This consistent feature agrees qualitatively well with the predictions from the tetraquark mixing framework and, therefore, provides supporting evidence for the tetraquark mixing.
Tumor-Infiltrating Lymphocyte Therapy in Melanoma: Facts to the Future
Authors: Betof Warner Allison , Corrie Pippa G. , Hamid Omid 
Published: December 2022

Abstract
Adoptive cell therapy with tumor-infiltrating lymphocytes (TIL) is gaining momentum and demonstrating durable responses in patients with advanced melanoma. Although increasingly considered as a treatment option for select patients with melanoma, TIL therapy is not yet approved by any regulatory agency. Pioneering studies with first-generation TIL therapy, undertaken before the advent of modern melanoma therapeutics, demonstrated clinical efficacy and remarkable long-term overall survival, reaching beyond 20 months for responding patients. TIL therapy is a multistep process of harvesting patient-specific tumor-resident T cells from tumors, ex vivo T-cell expansion, and re-infusion into the same patient after a lymphodepleting preparative regimen, with subsequent supportive IL2 administration. Objective response rates between 30% and 50% have consistently been observed in heavily pretreated patients with metastatic melanoma, including those who have progressed after modern immune checkpoint inhibitors and BRAF targeted agents, a population with high unmet medical need. Although significant strides have been made in modern TIL therapeutics, refinement strategies to optimize patient selection, enhance TIL production, and improve efficacy are being explored. Here, we review past and present experience, current challenges, practical considerations, and future aspirations in the evolution of TIL therapy for the treatment of melanoma as well as other solid tumors.
FDA Approval Summary: Ripretinib for Advanced Gastrointestinal Stromal Tumor
Authors: Kumar Vaibhav , Doros Leslie , Thompson Margaret , Mushti Sirisha L. , Charlab Rosane , Spehalski Elizabeth I. , Zhao Hong , Thompson Matthew D. , Tang Shenghui , Pazdur Richard , Lemery Steven J. , Theoret Marc R. , Fashoyin-Aje Lola A. 
Published: December 2022

Abstract
On May 15, 2020, the FDA approved ripretinib for adult patients with advanced gastrointestinal stromal tumor who have received prior treatment with three or more kinase inhibitors, including imatinib. The approval was based on results from INVICTUS (NCT03353753), an international, multi-center, double-blind, placebo-controlled trial. Patients were randomly allocated (2:1) to receive either ripretinib 150 mg once daily (n = 85) or matching placebo (n = 44). The trial demonstrated a statistically significant improvement in progression-free survival (PFS) as assessed by modified RECIST v1.1 by blinded independent central review for patients randomized to ripretinib, with a median PFS of 6.3 months [95% confidence interval (CI): 4.6–6.9] compared with 1.0 month (95% CI: 0.9–1.7) for placebo [HR: 0.15 (95% CI: 0.09–0.25); P &lt; 0.0001, stratified log-rank test]. There was no statistically significant difference in objective response rate in the ripretinib arm, 9% (95% CI: 4.2–18) compared with placebo 0% [(95% CI: 0–8); P = 0.0504, Fisher exact test]. The median overall survival (OS) in the ripretinib arm was 15.1 months (95% CI: 12.3–15.1) compared with 6.6 months (95% CI: 4.1–11.6) in the placebo arm. A formal statistical comparison of OS was not made due to the prespecified hierarchical analysis plan. The most common (≥20%) adverse events with ripretinib, in order of decreasing frequency, were alopecia, fatigue, nausea, abdominal pain, constipation, myalgia, diarrhea, decreased appetite, palmar-plantar erythrodysesthesia, and vomiting. Other important risks of ripretinib include new primary cutaneous malignancies, hypertension, and cardiac dysfunction.
Association of Parental Cardiovascular Health With Disability-Adjusted Life Years in the Offspring: Results From the Framingham Heart Study
Authors: Muchira James M. , Gona Philimon N. , Mogos Mulubrhan F. , Stuart-Shor Eileen M. , Leveille Suzanne G. , Piano Mariann R. , Hayman Laura L. 
Published: December 2022

Background:
Disability-adjusted life years (DALYs) are used to evaluate the relative burden of diseases in populations to help set prevention or treatment priorities. The impact of parental cardiovascular health (CVH) on healthy life years lost from cardiovascular disease (CVD) in adult offspring is unknown. We compared parent-offspring CVD DALYs trends over the life course and examined the association of parental CVH with offspring CVD DALYs.

Methods:
Using data from the Framingham Heart Study, 4814 offspring-mother-father trios were matched for age at selected baseline exams. CVH score was computed from the number of CVH metrics attained at recommended levels: poor (0–2), intermediate (3–4), and ideal (5–7). CVD DALYs were defined as the sum of years of life lost and years lived with CVD. Age-sex-standardized life expectancy and disability weights were derived from the actuarial life tables and Global Burden of Disease study, respectively. Multivariable-adjusted linear regression was used to investigate the association of parental CVH with offspring CVD DALYs.

Results:
Over an equal 47-year follow-up, parents lost nearly twice the number of CVD DALYs compared to their offspring (23 234 versus 12 217). However, age-adjusted CVD DALYs were higher at younger ages and similar along the life course for parents and offspring. One-unit increase in parental CVH was associated with 5 healthy life months saved in offspring. Offspring of mothers with ideal versus poor CVH had 3 healthy life years saved (β=−3.0 DALYs [95% CI, −5.6 to −0.3]). No statistically significant association was found between paternal CVH categories and offspring CVD DALYs.

Conclusions:
Higher maternal and paternal CVH were associated with increased healthy life years in offspring; however, the association was strongest between mothers and offspring. Investment in CVH promotion along the life course has the potential to reduce the burden of CVD in the current and future generation of adults.
Nationwide Implementation of a Population Management Dashboard for Monitoring Direct Oral Anticoagulants: Insights From the Veterans Affairs Health System
Authors: Dorsch Michael P. , Chen Charity S. , Allen Arthur L. , Sales Anne E. , Seagull F. Jacob , Spoutz Patrick , Sussman Jeremy B. , Barnes Geoffrey D. 
Published: December 2022

Background:
Direct oral anticoagulants are first-line therapy for common thrombotic conditions, including atrial fibrillation and venous thromboembolism. Despite their strong efficacy and safety profile, evidence-based prescribing can be challenging given differences in dosing based on indication, renal function, and drug-drug interactions. The Veterans Health Affairs developed and implemented a population management dashboard to support pharmacist review of anticoagulant prescribing. The dashboard includes information about direct oral anticoagulants and dose prescribed, renal function, age, and weight, potential interacting medications, and the need for direct oral anticoagulant medication refills. It is a stand-alone system.

Methods:
Using login data from the dashboard, nationwide implementation was evaluated using elements from the Reach, Effectiveness, Adoption, Implementation, and Maintenance framework.

Results:
Between August 2016 and June 2020, 150/164 sites within the Veterans Health Affairs system used the dashboard, averaging 1875 patients per site. The dashboard was made available to sites on a staggered basis. Moderate or high adoption, defined as at least one login on at least 2 separate days per month, began slowly with 3/5 sites in the pilot phase but rapidly grew to 142/150 (94.7%) sites by June 2020. The average number of unique users per site increased from 2.4 to 7.5 over the study period. Moderate to high adoption of the dashboard’s use was maintained for > 6 months in 126/150 (84.0%) sites by the end of the study period.

Conclusions:
There was rapid and sustained implementation and adoption of a population health dashboard for evidence-based anticoagulant prescribing across the national United States Veterans Health Administration health system. The impact of this tool on clinical outcomes and strategies to replicate this care model in other health systems will be important for broad dissemination and uptake.
Habitat use and body temperature influence push-up display rate in the tree lizard, Urosaurus ornatus
Authors: Goerge Tyler M. , Miles Donald B. 
Published: December 2022

Abstract
Lizards engage in push-up displays to signal dominance and to secure access to important resources. The rate and patterns of push-up displays have been shown to vary based on both biotic and abiotic factors. We investigated push-up display rate in tree lizards, Urosaurus ornatus, to determine contributions from potentially conflicting factors including sex, throat colour, microhabitat usage, social context, and thermal traits. We found that display rate was best described by an interaction between microhabitat and body temperature (Tb). The relationship between display rate and Tb was significantly different between three microhabitats: sunny dead trees, the inner branches of trees, and tree trunks. We suggest that this variation in display rate is driven by shifts in microhabitat temperature over the course of the day and spatial and temporal adjustments being made depending on the probabilities of being detected by both conspecifics and predators.
Chance Encounters
Authors: Hens Kristien 
Published: December 2022

In this rigorous and necessary book, Kristien Hens brings together bioethics and the philosophy of biology to argue that it is ethically necessary for scientific research to include a place for the philosopher. As well as ethical, their role is conceptual: they can improve the quality and coherence of scientific research by ensuring that particular concepts are used consistently and thoughtfully across interdisciplinary projects. Hens argues that chance and uncertainty play a central part in bioethics, but that these qualities can be in tension with the attempt to establish a given theory as scientific knowledge: in describing organisms and practices, in a sense we create the world. Hens contends that this is necessarily an ethical activity.
Examining genetic research, biomedical ethics, autism research and the concept of risk, Hens illustrates that there is no ‘universal’ or ‘neutral’ state of scientific and clinical knowledge, and that attending to the situatedness of individual experience is essential to understand the world around us, to know its (and our) limitations, and to forge an ethical future.
Chance Encounters is aimed at a broad audience of researchers in bioethics, philosophy, anthropology, sociology, as well as biomedical and environmental scientists. It will also be relevant to policymakers, and the artwork by Christina Stadlbauer and Bartaku will be of interest to artists and writers working at the intersection of art and science.
Derivation and Validation of a Prognostic Model for Mortality in Chinese Patients with Acute Pulmonary Embolism
Authors: Zhang Jiarui , Ali Adila , Liu Yu , Peng Lige , Pu Jiaqi , Yi Qun , Zhou Haixia 
Published: December 2022

Introduction We aim to explore the risk factors for in-hospital mortality and to derive a prognostic model for patients with APE in China. Materials and methods Inpatients with APE were enrolled from West China Hospital between January 2016 and December 2019. Logistic regression analyses were used to explore risk factors for in-hospital mortality and develop a prognostic model. Results A total of 813 subjects with APE were included in this study, of whom 542 were in the training set and 271 were in the test set. Multivariable regression analyses indicated that age, male, heart rate, systolic blood pressure, elevated NT-proBNP or troponin T, malignancy, chronic renal insufficiency, and respiratory failure were independent risk factors for in-hospital mortality. For the training set, the area under the curve (AUC) of the ROC curve was 0.899, with a sensitivity and specificity of 89.7% and 77.7%, respectively. The model had higher prediction accuracy than the PESI and sPESI. Conclusions The prediction model has proven excellent discrimination and calibration, which may be a useful tool to help physicians make decisions regarding the best treatment strategy.