bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of wireless and wired alarm devices for nocturnal enuresis treatment
Authors: Watanabe Tsuneki , Ikeda Hirokazu , Ono Takahiro , Oyake Chisato , Watanabe Yoshitaka , Fuyama Masaki 
Published: August 2022

AbstractBackgroundIn monosymptomatic nocturnal enuresis (MNE) treatment, enuretic alarm devices are the first recommended treatment option. This study aimed to compare retrospectively the effectiveness of wearable wireless and wired alarm devices for MNE treatment in children aged 6–14 years.MethodsAll children aged 6–16 with MNE who underwent alarm therapy as outpatients were included. A wired alarm device was used from 2012 to 2015, and a wireless alarm device was used from 2016 to 2019. The primary outcomes were the dropout rates during therapy and at last follow up. The full response(14 consecutive dry nights) and the partial response rate during therapy were also assessed.ResultsOf the 173 patients enrolled, 75 and 98 used a wired and a wireless alarm device, respectively. The dropout rate at the last visit was significantly lower in the wireless alarm group than that in the wired alarm group (6.1% vs. 20.0%; P = 0.006). The full response(FR) rate was significantly higher in the wireless alarm group than these in the wired alarm group at 4, 12, 24 weeks (4 weeks: 11.2% vs. 1.3%, P = 0.011; 12 weeks: 31.9% vs. 13.5%, P = 0.005; 24 weeks: 72.9% vs. 39.7%, P < 0.0001).ConclusionsWireless alarm therapy for MNE had lower attrition rates and a higher rate of FR than wired alarm therapy.
Cohort profile: The PreEclampsia, Angiogenesis, Cardiac dysfunction and Hypertension (PEACH) Study
Authors: Persson Lisa Kristine Grange , Lihme Frederikke Fog , Basit Saima , Larsen Maria Oku , Scheller Nikolai Madrid , Andersen Anita Sylvest , Halse Karen Green , Thorsen‐Meyer Annette , Sørensen Karina Meden , Wohlfahrt Jan , Melbye Mads , Pihl Kasper Kai Østrup , Lykke Jacob Alexander , Boyd Heather Allison 
Published: August 2022

AbstractBackgroundHypertensive disorders of pregnancy (HDP) remain a leading cause of maternal morbidity and mortality worldwide, with implications for maternal and neonatal well‐being in the short term and for long‐term maternal cardiovascular health. Although the mechanisms behind HDP remain incompletely understood, evidence suggests that preeclampsia in particular is a syndrome with more than one distinct subtype.ObjectivesThe PEACH (PreEclampsia, Angiogenesis, Cardiac dysfunction, Hypertension) Study was established to identify new HDP subtyping systems reflecting aetiology and prognosis and to find markers of later cardiovascular disease risk associated with preeclampsia.PopulationThe PEACH Study recruited pregnant women referred to two Copenhagen‐area hospitals with suspected preeclampsia (mean gestational age at enrolment: 36.7 weeks) and a group of frequency‐matched pregnant women planning delivery at the same hospitals and healthy when enrolled mid‐pregnancy.DesignProspective, longitudinal pregnancy cohort.MethodsParticipants underwent repeated third‐trimester blood sample collection, longitudinal cardiac function assessments using the USCOM‐1A during the third trimester and at 1 year postpartum and collection of placental samples immediately after delivery. Medical information was abstracted from medical records and hospital databases.Preliminary resultsDuring 2016–2018, we recruited 1149 pregnant women, of whom 1101 were followed to delivery. Among 691 women enrolled with suspected preeclampsia, 310 and 172 developed preeclampsia and gestational hypertension respectively. Among 410 women with healthy pregnancies when enrolled mid‐pregnancy, 37 later developed hypertensive disorders of pregnancy. Of 1089 women still in the cohort 1 year postpartum, 578 (53.1%) participated in the follow‐up assessment.ConclusionsThe PEACH Study's rich data from women with and without HDP will enable us to identify new, clinically useful HDP subtypes to aid in decision‐making regarding monitoring and treatment. Continued postpartum follow‐up will help us develop algorithms to identify women at risk of persistent postpartum cardiac dysfunction and later cardiovascular disease after pregnancies complicated by HDP.
Comprehensive evaluation of high‐temperature tolerance induced by heat priming at early growth stages in winter wheat
Authors: Khanzada Anab , Feng Kai , Wang Xiao , Cai Jian , Malko Maguje Masa , Samo Allan , Hossain Md Nazmul , Jiang Dong 
Published: August 2022

AbstractPriming is a potential way to enhance stress tolerance in plants. Winter wheat adaptation to harsh environmental conditions is a prominent global predicament. To enhance the productivity and its tolerance to rapidly changing world's environment, wheat plants were subjected to different heat priming events at early growth stages, which effects were studied on subsequent heat stress at booting and flowering stages. The study aimed to observe the major changes in photosynthetic characteristics, antioxidant enzymes system, and sugar metabolism in leaves during wheat adaptation to heat stress applied at booting and flowering stages after heat priming at early growth stage. Heat stress mostly affected the plant's development with a significant reduction in yield, yield components, biomass, osmotic potential (OP), leaf relative water potential (LRWP), and plant photosystem. However, the concomitant increase of membrane injury index (MII), reactive oxygen species (ROS) production, enzymatic activities, and sugar metabolism in primed plants enabled winter wheat plants to tolerate heat stress more after low heat priming (LP) than moderate heat priming (MP). Furthermore, MP at early growth stages reduced the biomass, OP, LRWP, and photosynthetic system while the remarkable increase in sugar metabolism and enzymatic activities increased the ROS production, yield, and yield components under heat stress applied at booting stage. Similarly, LP successfully improved plant tolerance to heat stress applied at flowering stage. In conclusion, LP at early growth stage was beneficial to sustain to heat stress during flowering stage, while MP at early growth stage helped winter wheat to better adapt to heat stress at booting stage. These results encompass a novel research direction for the adaptation of winter wheat to harsh environmental conditions to reduce yield loss.
Black adolescents’ support to the family and educational outcomes: Differences by household income
Authors: Armstrong‐Carter Emma 
Published: August 2022

AbstractUsing a strengths‐based approach, this study investigated whether Black adolescents’ provision of different types of support to family (chores, childcare, emotional, financial support) was associated with their educational outcomes (school engagement, grades, suspensions), and whether these associations differed by household income levels. The study used the nationally representative National Survey of American Life Adolescent Supplement data (N = 1170, 52% Female, ages of 13–17). Supporting the family was associated with both educational success and risk, depending on the type of support and household socioeconomic resource levels. Across income groups, providing emotional support was associated with greater school engagement. Among low‐income youth only, completei chores was associated with higher school engagement and grades, whereas providing childcare was associated with lower grades.
Film Cooling Performance Prediction for Air and Supercritical CO2
Authors: Ramesh Sridharan , Straub Douglas 
Published: August 2022

Abstract
The current study explores the possibility of cooling the vanes and blades of a direct-fired sCO2 turbine using film cooling. The operating conditions of a direct-fired sCO2 cycle and thermophysical properties of the fluid at those conditions can alter the flow field characteristics of the coolant jet and its mixing with the mainstream. Very little information is present in the literature regarding the performance of film cooling geometries employing supercritical CO2. The objective of this study is to estimate the resulting film cooling effectiveness while also capturing the effects of the crossflow-to-mainstream velocity ratio on the coolant jet. A computational fluid dynamic model is used to study the coolant jet exiting a cylindrical hole located on a flat plate, with the coolant fed by an internal channel. Steady-state Reynolds-averaged Navier–Stokes equations were solved along with the (shear-stress transport) SST k–ω model to provide the turbulence closure. The operating conditions for the direct-fired sCO2 turbine are obtained using an in-house Cooled Turbine Model. Numerical predictions revealed that the crossflow effects and jet lift-off were more pronounced in the case of sCO2 when compared to air. Spatial distribution of flow field and cooling effectiveness are presented at different operating conditions.
Experimental Investigation of Gaseous Mixtures of Ethane, Methane, and Carbon Dioxide as an Alternative to Conventional Fuel in Spark Ignition Engines
Authors: Gore Matthew , Nonavinakere Vinod Kaushik , Fang Tiegang 
Published: August 2022

Abstract
This study investigates the viability and performance of certain synthetic fuels in spark ignition internal combustion engine based stationary power generation wherein the fuel comprises a mixture of methane and ethane in high dilutions of carbon dioxide (CO2). The fuel of concern is a byproduct of a novel method for producing ethylene from ethane. The byproduct gas mixture has a concentration of approximately 41% CO2, 40% ethane, and 5% methane by weight along with other minor compounds. Varying mixtures of ethane and methane combined with between 42% and 46% by weight CO2 were used to evaluate the viability and efficiency of this fuel to operate in existing internal combustion engines as a means of reducing emissions and increasing industrial process efficiency. A 13 hp gasoline generator was repurposed as a test stand by incorporating a modified fuel induction system and instrumentation for data collection. A gas metering and mixing system was installed to precisely control the mass flow of gases induced into the engine. Various instrumentations were installed to monitor in-cylinder pressure, temperature at various locations, emissions, and fuel and airflow rates. Varying fuel mixtures and loads were tested and compared to gasoline. It was found that under a high load, the mixed gas was able to generate comparable thermal efficiency and power to gasoline. But under no load or a part load condition the indicated thermal efficiency was found to be about 21% lower than that of gasoline. Further, the mixed gas also resulted in up to 50% reduction in CO and NOx emissions when compared to gasoline.
Integrated Optimization of Hybrid Steam-Solvent Processes in a Post-CHOPS Reservoir with Consideration of Wormhole Networks
Authors: Zhao Min , Yang Daoyong 
Published: August 2022

Abstract
In this paper, an integrated technique has been developed to evaluate and optimize performance of hybrid steam-solvent processes in a post-cold heavy oil production with sand (CHOPS) reservoir with consideration of wormhole networks. A reservoir geological model is developed and calibrated by history matching reservoir pressure with oil, gas, and water production rates as the input constraints, while its wormhole network is characterized with a newly developed pressure-gradient-based (PGB) sand failure criterion conditioned to sand production. Once calibrated, the reservoir geological model incorporated with the wormhole network is then employed to evaluate and optimize performance of hybrid steam-solvent processes under various conditions, during which the net present value (NPV) is maximized with an integrated optimization algorithm by taking injection time, soaking time, production time, and injected fluid composition as controlling variables. It is found that a huff-n-puff process imposes a positive impact on enhancing oil recovery when wormhole network is fully generated and propagated. Addition of alkane solvents into CO2 stream leads to a higher oil recovery compared with that of the CO2 only method, while all hybrid steam-solvent injection achieve high oil recovery by taking advantage of both thermal energy and solvent dissolution. It is found that the NPV reaches its maximum value when the steam temperature is 200 °C for the optimized hybrid steam-solvent scenario.
Effect of Hematite Dosage on Water-Based Drilling Fluid and Filter Cake Properties
Authors: Bageri Badr , Jaberi Jaber Al , Elkatatny Salaheldin 
Published: August 2022

Abstract
Drilling deep wells became common in the oil and gas sector as a result of the high demand for energy in the world. This type of wells is not trivial to drill as a result several challenges that they encounter, such as harsh conditions represented by high-pressure and high-temperature (HPHT), and the high hydrostatic column required to prevent the kick. Therefore, advanced materials are desired and accordingly higher concentration of weighting material is required to drill such resources. In this work, a systematic investigation of the hematite concentration effect on the water-based drilling fluid properties is performed. Three doses were overloaded to a constant drill fluid recipe. Then, the drilling fluid properties including density, viscosities, filtration, and filter cake properties were evaluated. The viscosities were assessed at the temperature of 120 °F, before and after aging in a hot rolling oven for 16 h at 250 °F and 500 psi. The American Petroleum Institute filtration test was performed at ambient temperature and 100 psi. The results showed that the hematite concentration has proportional relation to the apparent viscosity, plastic viscosity, and yield point before and after the hot rolling. The YP/PV ratio was decreased as the hematite dose increased in the drilling fluid. Similarly, the gel strengths at 10 s and 10 min were increased as the concentration of hematite increased. The filter cake thinness, filtration volume, and filter cake permeability were also amplified as the hematite concentration increased, where the filter cake porosity was almost kept constant. In addition, several correlations were drawn as a function of the hematite dosage for the examined drilling properties.
Supplemental Material: Onset of long-lived silicic and alkaline magmatism in eastern North America preceded Central Atlantic Magmatic Province emplacement
Authors: Kinney Sean , al. et 
Published: August 2022

<p>Figures S1–S49 (zircon images, Concordia and weighted mean plots and the results of MCMC modeling); Tables S1 and S2 (detailed sample information and detailed methods for LA-ICP-MS analyses); and Datasets S1–S3 (whole rock chemistry and measured isotopic data for all samples). </p>
Volcano-pluton connections at the Lake City magmatic center (Colorado, USA)
Authors: Pamukçu Ayla S. , Schoene Blair , Deering Chad D. , Keller C. Brenhin , Eddy Michael P. 
Published: August 2022

Abstract
Exposed at the Lake City caldera (Colorado, USA) is the ca. 23 Ma reversely stratified (rhyolite to trachyte) Sunshine Peak Tuff and post-collapse syenite and monzonite resurgent intrusions. Existing models for this system suggest that the rhyolites are related to the trachyte and resurgent syenite through fractional crystallization, separation, and remobilization (crystal mush model), and that multiple magma batches were involved in the system (Hon, 1987; Kennedy et al., 2016; Lubbers et al., 2020). We use U-Pb zircon CA-ID-TIMS-TEA and zircon trace-element modeling to further probe age and geochemical relationships between the extrusive and intrusive units. Zircon ages and compositions from the erupted units and the syenite overlap, suggesting these magmas were related and may have mixed prior to eruption. Results from the monzonite suggest it was a contemporaneous but distinct magma batch that mixed with parts of the larger system. Trends in zircon geochemistry are decoupled from time, reflecting a complex history of accessory mineral saturation and mixing of magma batches, and a distinct high-Hf population of zircon grains hints at the existence of an additional, independent batch of rhyolitic magma in the system. The new ages we present shorten the lifetime of the Lake City magmatic system from 80 to 300 k.y. (Bove et al., 2001) to 60 to 220 k.y. and suggest the high-silica rhyolite magma crystallized over a minimum of ~160 k.y. This latter timescale likely reflects a protracted history that includes differentiation of a parent melt prior to extraction of eruptible high-silica rhyolite magma.
Development of the Whitehorse trough as a strike-slip basin during Early to Middle Jurassic arc-continent collision in the Canadian Cordillera
Authors: van Drecht Leigh H. , Beranek Luke P. , Colpron Maurice , Wiest Adam C. 
Published: August 2022

Abstract
The Whitehorse trough is a synorogenic basin in the northern Cordillera that resulted from arc-collision processes along the northwestern margin of North America, but its filling history and tectonic significance remain uncertain. New detrital zircon U-Pb-Hf isotope analyses of 12 rock samples, including six basal sandstones that sit unconformably on Triassic rocks of Stikinia, were combined with published detrital zircon and fossil data to establish the depositional ages of synorogenic Laberge Group strata in Yukon and test proposed links between Intermontane terrane exhumation and basin-filling events. Laberge Group strata yielded 205–170 Ma and 390–252 Ma detrital zircon populations that indicate derivation from local Late Triassic to Middle Jurassic arc and syncollisional plutons and metamorphosed Paleozoic basement rocks of the Stikinia and Yukon-Tanana terranes. Basal sandstone units have Early Jurassic depositional ages that show the Whitehorse trough filled during early Sinemurian, late Sinemurian to Pliensbachian, and Toarcian subsidence events. Late Triassic to Early Jurassic detrital zircon grains confirm that syncollisional plutons near the northern trough were exhumed at 0.5–7.5 mm/yr and replicate their excursion to subchondritic Hf isotope compositions as a result of increasing crustal contributions from Rhaetian to Sinemurian time. The new detrital zircon data, combined with recent constraints for Triassic–Jurassic metamorphism and magmatism in Yukon, require modification of published forearc to syncollisional basin models for the Whitehorse trough. We reinterpret Jurassic subsidence patterns and architecture of the Whitehorse trough to reflect sinistral transtension within a transform fault system that resulted from the reorganization of subduction after end-on arc collision.
Realist evaluation of the impact, viability and transferability of an alcohol harm reduction support programme based on mental health recovery: the Vitae study protocol
Authors: Martin-Fernandez Judith , Stevens Nolwenn , Moriceau Sarah , Serre Fuschia , Blanc Hélène , Latourte Emmanuelle , Auriacombe Marc , Cambon Linda 
Published: August 2022

IntroductionAddiction is considered a chronic disease associated with a high rate of relapse as a consequence of the addictive condition. Most of the current therapeutic work focuses on the notion of relapse prevention or avoidance and the control of its determinants. Since only a small portion of patients can access alcohol addiction treatment, it is crucial to find a way to offer new support towards safe consumptions, reductions or cessations. The harm reduction (HR) approach and mental health recovery perspective offers another way to support the patient with alcohol addiction. Vitae is a realist evaluation of the impact, viability and transferability of the IACA! programme, an HR programme based on the principle of psychosocial recovery for people with alcohol use disorders.Methods and analysisThe Vitae study adheres to the theory-driven evaluation framework where the realist evaluation method and contribution analysis are used to explore the effects, mechanisms and influence of context on the outcomes and to develop and adjust an intervention theory. This study is a 12-month, multi-case, longitudinal descriptive pilot study using mixed methods. It is multi-centred, and carried out in 10 addiction treatment or prevention centres. In this study, outcomes are related to the evolution of alcohol use and the beneficiaries trajectory in terms of psychosocial recovery during these 12 months after the start of IACA!. The target number of participants are 100 beneficiaries and 23 professionals.Ethics and disseminationThis research was approved by the Committee for the Protection of Persons Ouest V n°: 21/008-3HPS and was reported to the French National Agency for the Safety of Health Products. All participants will provide consent prior to participation. The results will be reported in international peer-reviewed journals and presented at scientific and public conferences.Trial registration numbersNCT04927455; ID-RCB2020-A03371-38.
Younger age at multiple sclerosis onset is associated with worse outcomes at age 50
Authors: Bose Gauruv , Healy Brian C , Barro Christian , Glanz Bonnie I , Lokhande Hrishikesh A , Polgar-Turcsanyi Mariann , Guttmann Charles RG , Bakshi Rohit , Weiner Howard L. , Chitnis Tanuja 
Published: August 2022

ObjectiveOlder age at multiple sclerosis (MS) onset has been associated with worse 10-year outcomes. However, disease duration often exceeds 10 years and age-related comorbidities may also contribute to disability. We investigated patients with>10 years disease duration to determine how age at MS onset is associated with clinical, MRI and occupational outcomes at age 50.MethodsWe included patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women’s Hospital with disease duration>10 years. Outcomes at age 50 included the Expanded Disability Status Scale (EDSS), development of secondary-progressive multiple sclerosis (SPMS), brain T2-lesion volume (T2LV) and brain parenchymal fraction (BPF), and occupational status. We assessed how onset age was independently associated with each outcome when adjusting for the date of visit closest to age 50, sex, time to first treatment, number of treatments by age 50 and exposure to high-efficacy treatments by age 50.ResultsWe included 661 patients with median onset at 31.4 years. The outcomes at age 50 were worse the younger first symptoms developed: for every 5 years earlier, the EDSS was 0.22 points worse (95% CI: 0.04 to 0.40; p=0.015), odds of SPMS 1.33 times higher (95% CI: 1.08 to 1.64; p=0.008), T2LV 1.86 mL higher (95% CI: 1.02 to 2.70; p<0.001), BPF 0.97% worse (95% CI: 0.52 to 1.42; p<0.001) and odds of unemployment from MS 1.24 times higher (95% CI: 1.01 to 1.53; p=0.037).ConclusionsAll outcomes at age 50 were worse in patients with younger age at onset. Decisions to provide high-efficacy treatments should consider younger age at onset, equating to a longer expected disease duration, as a poor prognostic factor.