bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of diffuse lung function in children with Mycoplasma pneumoniae pneumonia
Authors: Wang Li , Li Qianqian , Hu Jie , Luo Ronghua , Duan Yaping , Ai Tao 
Published: January 2025

BackgroundMycoplasma pneumoniae infection accounts for a high proportion of community-acquired pneumonia and the incidence rate of severe M. pneumoniae pneumonia (MPP) has increased year by year. This study investigated the changes in lung diffusion function after M. pneumoniae infection, compared the lung diffusion and ventilation function of children with mild (MMPP) or severe M. pneumoniae pneumonia (SMPP) infections, and explored their clinical significance.ObjectiveTo study the changes in pulmonary ventilation and pulmonary diffusion function in children with MPP, and explore their clinical significance.MethodsData from 97 children with M. pneumoniae pneumonia hospitalized in Chengdu Women and Children's Central Hospital from June 2023 to December 2023 were collected and the participants were divided into an MMPP group (n = 44) and an SMPP group (n = 53). The changes in pulmonary ventilation function and diffusion function were compared between the two groups.ResultsThe Z-scores of forced vital capacity and forced expiratory volume in the first second in the SMPP and MMPP groups were −1.684 ± 0.902 and −1.986 ± 0.818, and 0.164 ± 1.795 and −0.6104 ± 1.276, respectively. In the SMPP group, the two aforementioned indicators were lower than the normal value and significantly lower than those in the MMPP group (P &lt; 0.001). The carbon monoxide diffusion capacity in the SMPP group (−5.931 ± 0.827) was significantly lower than that in the MMPP group (−5.0775 ± 1.1134) (P &lt; 0.001). The forced expiratory flow at 75% vital capacity and the maximum mid expiratory flow in the SMPP group were −2.006 ± 1.2582 and −1.878 ± 1.008, respectively, which were lower than the normal value.ConclusionSMPP results in more severe ventilation dysfunction and diffuse dysfunction than MMPP.
Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders (ERI-SIBS): a controlled trial of an innovative and ecological intervention for siblings of children with autism spectrum disorder
Authors: Annunziata Silvia , Purpura Giulia , Piazza Elena , Meriggi Paolo , Fassina Gabriele , Santos Laura , Ambrosini Emilia , Marchetti Antonella , Manzi Federico , Massaro Davide , Tacci Andrea Luna , Bolognesi Elisabetta , Agostini Simone , La Rosa Francesca , Pedrocchi Alessandra Paola Giulia , Molina Paola , Cavallini Anna 
Published: January 2025

BackgroundIt has been widely demonstrated that siblings of children with autism spectrum disorder (ASD) have an increased risk of abnormal developmental trajectories. In response to this, early recognition protocols have been developed worldwide, aiming to promote early interventions that can positively impact the neurodevelopment of this population. This paper presents the protocol of a controlled trial: ERI-SIBS (Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders) is an innovative and ecological early recognition and intervention program designed specifically for siblings of children with ASD.MethodsWe aim to recruit siblings at low risk and high risk of neurodevelopmental disorders. Based on clinical evaluation at T0, we will allocate the infants into three groups: Group 1, infants at low risk without any signs of neurodevelopmental disorders; Group 2, infants at high risk without any signs of neurodevelopmental disorders; Group 3: infants at low or high risk with signs suggestive of neurodevelopmental disorders. Children of Group 2 will undergo Active Monitoring (one 90 min session once a month for 6 months), while children of Group 3 will undergo Early Intervention (one 90 min session once a week for 6 months). In both cases, the ERI-SIBS contents are based on a multidimensional and naturalistic approach and always involve caregivers. All recruited children will be evaluated at three different time points (T0 within the 8 months of life of the child, T1 after 6 months and T2 after 12 months) using behavioural, technological, and biological techniques to assess infants’ neurodevelopmental functions, parent-infant interaction, and early ASD markers.DiscussionThe ERI-SIBS study will expand knowledge regarding the impact of early intervention on families of infants at risk of neurodevelopmental disorders for the presence of a child with a diagnosis of ASD. The study will have the potential to significantly contribute to future research and the scientific and clinical debate on the best way to implement early intervention in at-risk populations.
Clinical Trial RegistrationClinicaltrials.gov identifier (NCT06512649).
Exploring the experiences of children's palliative care for forced migrant families in the United Kingdom: an interpretative phenomenological study
Authors: Clancy Marie , Bradbury-Jones Caroline , Phillimore Jenny , Taylor Julie 
Published: January 2025

IntroductionThis study focused on understanding the experiences of forced migrant families and the health care professionals who care for them within palliative care. Palliative care for children requires an active, holistic approach to care, with a focus upon improving quality of life. Forced migrant families encounter a range of additional challenges including the loss of family, belongings, and all sources of familiarity and support. The difficulties of navigating complex bureaucratic systems can confound access and communication difficulties.MethodsInterpretative Phenomenological Analysis methodology was used in this study to privilege participant perspectives and apply an active in-depth cyclical process of reflection and reflexivity. Advisory group members provided expertise in childhood illness, palliative care and forced migration, throughout the study. The Silences Framework offered novel theoretical and philosophical concepts, which helped to situate and prioritise the “silences” within the marginalised discourses of forced migration and palliative care. Seven family members and seven health care professional participants were interviewed from hospital, hospice and community palliative care settings in the UK.ResultsFour overarching themes were identified related to experiences of loss and grief, communication, faith and coping strategies and alienation and discrimination. Compassionate, empathetic, family-centred care which valued family belief systems and coping strategies, optimised care. Learning with and from families was described by all participants, which enhanced understanding and fostered mutual respect. However, barriers included poor access to services and resources, protocol-led care, limited time with families, communication barriers and staff burnout.DiscussionThe findings suggest the need for a specific educational pathway for palliative care professionals to include spiritual care provision, cultural humility, and moral reasoning. Interdisciplinary education including the use of lived-experience expert insights is also advocated. Sufficient time to build relationships, the importance of interpreter support and the need for better access to hospice care for forced migrant families is also recommended.
Study on the sedative effect and safety of oral midazolam combined with dexmedetomidine nasal drops in children during magnetic resonance imaging examination
Authors: Li Yuancui , Lei Rongzhu 
Published: January 2025

BackgroundMagnetic resonance imaging (MRI) is a crucial non-invasive diagnostic tool for pediatric diseases, requiring patients to remain still, often with the use of sedatives. Midazolam and dexmedetomidine are commonly used for sedation in children, but their combined effect needs further study. This study aims to evaluate the safety and effectiveness of combining intranasal dexmedetomidine (ID) with oral midazolam (OM) in children undergoing MRI, and assess its clinical feasibility.MethodsA prospective, randomized controlled trial was conducted with 196 pediatric patients undergoing MRI from January 2022 to December 2023. Patients were randomly assigned to a control group (OM alone) or an observation group (OM + ID), with 98 cases each. Total sedation time, wake-up time, onset time, and adverse reactions were evaluated. Sedation effectiveness was assessed using the Ramsay Sedation Score.ResultsThe observation group had significantly longer total sedation time (P = 0.039) and higher one-time sedation success rate (P = 0.038) compared to the control group. The Ramsay score indicated better sedation effects in the observation group (P &lt; 0.05). Adverse events were similar between groups and resolved with rest.ConclusionCombining ID with OM provides effective sedation for pediatric MRI, with an acceptable safety profile, supporting its use in clinical practice.
The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology
Authors: Hagan Abraham Tonny , Xu Lei , Klugah-Brown Benjamin , Li Jialin , Jiang Xi , Kendrick Keith M. 
Published: January 2025

IntroductionNeuroimaging studies have demonstrated that intranasal oxytocin has extensive effects on the resting state functional connectivity of social and emotional processing networks and may have therapeutic potential. However, the extent to which intranasal oxytocin modulates functional connectivity network topology remains less explored, with inconsistent findings in the existing literature. To address this gap, we conducted an exploratory data-driven study.MethodsWe recruited 142 healthy males and administered 24 IU of intranasal oxytocin or placebo in a randomized controlled double-blind design. Resting-state functional MRI data were acquired for each subject. Network-based statistical analysis and graph theoretical approaches were employed to evaluate oxytocin’s effects on whole-brain functional connectivity and graph topological measures.ResultsOur results revealed that oxytocin altered connectivity patterns within brain networks involved in sensory and motor processing, attention, memory, emotion and reward functions as well as social cognition, including the default mode, limbic, frontoparietal, cerebellar, and visual networks. Furthermore, oxytocin increased local efficiency, clustering coefficients, and small-world propensity in specific brain regions including the cerebellum, left thalamus, posterior cingulate cortex, right orbitofrontal cortex, right superior frontal gyrus, left inferior frontal gyrus, and right middle orbitofrontal cortex, while decreasing nodal path topological measures in the left and right caudate.DiscussionThese findings suggest that intranasal oxytocin may produce its functional effects through influencing the integration and segregation of information flow within small-world brain networks, particularly in regions closely associated with social cognition and motivation.
Administration of anticoagulation strategies for portal vein thrombosis in cirrhosis: network meta-analysis
Authors: Li Hui-Jun , Yin Fu-Qiang , Ma Yu-Tong , Gao Teng-Yu , Tao Yu-Ting , Liu Xin , Shen Xian-Feng , Zhang Chao 
Published: January 2025

ObjectivesEvidences for anticoagulation strategies in cirrhotic with portal vein thrombosis (PVT) are still insufficient. This study aims to comprehensively compare the therapeutic effects of different therapeutic therapeutic measures in individuals suffering from cirrhosis with PVT, with the ultimate goal of providing evidence-based recommendations for thrombolytic therapy in this population.MethodsStarting from 20 October 2023, a comprehensive search about therapeutic strategies for portal vein thrombosis in cirrhosis was conducted on PubMed, EMBASE, and Cochrane Library.Results19 studies were eventually incorporated into this study. Comparison with control in network meta-analysis, direct oral anticoagulants (DOACs) (RR = 2.15, 95%CI: 1.33, 3.48), LMWH (RR = 1.41, 95%CI: 1.01, 1.99), TIPS (RR = 5.68, 95%CI: 2.63, 12.24), warfarin (RR = 2.16, 95%CI: 1.46, 3.21), EBL plus propranolol (RR = 2.80, 95%CI: 1.18, 6.60), LMWH-DOACs sequential (RR = 7.92, 95%CI: 2.85, 21.99) and LMWH-warfarin sequential (RR = 2.26, 95%CI: 1.16, 4.42) significantly improved the incidence of complete recanalization. The anticoagulation drugs were ranked based on their SUCRA values, with the LMWH-DOACs sequential (92.7%), TIPS plus warfarin (91.3%), and TIPS (80.3%) emerging as the top three effective treatments.ConclusionIn this study, active anticoagulants were recommended for cirrhosis with PVT. The TIPS plus warfarin, LMWH-DOACs sequential, and TIPS improved the complete recanalization rate most effectively, and the EBL plus propranolol, heparin plus DOACs plus warfarin, and DOACs were highly recommended for increasing the incidence of partial recanalization. Warfarin and TIPS were recommended for reducing the frequency of bleeding events, while LMWH plus warfarin and DOACs proved to be most effective in decreasing the rate of major bleeding events. Warfarin, heparin plus DOACs plus warfarin, and DOACs demonstrated the most significant reduction in mortality rates, highlighting its potential as an effective intervention. TIPS plus warfarin, LMWH-DOACs sequential, and TIPS were recommended for reducing the occurrence of PVT expansion. Heparin plus DOACs plus warfarin was recommended for reducing the occurrence of hepatic encephalopathy, and protocols that involve TIPS were generally associated with a higher risk of hepatic encephalopathy. However, a longer follow-up period is necessary to comprehensively evaluate the efficacy of active anticoagulants therapy in patients with PVT in cirrhosis.
Protective effects of small RNAs encapsulated in Artemisia Capillaris-derived exosomes against non-alcoholic fatty liver disease
Authors: Xu Min , Ma Longjun , Liang Hongwei , Tang Wei , Gu Shouyong 
Published: January 2025

IntroductionArtemisia capillaris, a traditional medicinal plant, is renowned for its therapeutic properties, including the promotion of anti-inflammatory and bile secretion. Notably, it has demonstrated efficacy in the treatment of jaundice. This study aimed to evaluate the potential of Artemisia capillaris-derived exosomes (ACDEs) as a novel therapeutic approach in non-alcoholic fatty liver disease (NAFLD).MethodsThe physicochemical properties of ACDEs were isolated and characterized using differential centrifugation, and the therapeutic efficacy was evaluated in an in vivo methionine-choline-deficient (MCD) diet induced NAFLD mouse model. In vitro, mouse hepatocytes were treated with palmitic acid (PA) to simulate a high fat environment. Intracellular triglycerides (TG) and total cholesterol (TC) levels were quantified, and Oil Red O staining was assessed. Additionally, the expression levels of proteins and RNAs associated with lipogenesis and inflammation were analyzed.ResultsThe NAFLD mouse model exhibited notable liver damage, including lipid deposition and inflammatory responses. However, treatment with ACDEs exhibited broad pharmacological activities, effectively reversing hepatic lipid accumulation and inflammatory damage. In vitro experiments revealed that ACDEs were internalized by AML12 cells via macropinocytosis and caveolin-mediated endocytosis. This treatment ameliorated dysregulated lipid metabolism and inhibited inflammatory responses. High throughput sequencing further identified a distinct small RNA profile in ACDEs, indicating the potential involvement in interspecies physiological regulation.DiscussionIn conclusion, this study provides evidence for the therapeutic potential of ACDEs in NAFLD and offers a novel perspective for the development of Artemisia capillaris-based therapies for NAFLD, related metabolic disorders, and hepatitis.
CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium
Authors: Chen Zhixuan , Qu Huayi , Sun Jian , Wang Tao , Yuan Yan , Gu Jianhong , Bian Jianchun , Liu Zongping , Zou Hui 
Published: January 2025

IntroductionCadmium (Cd) and polystyrene microplastics (PS-MPs), two ubiquitous environmental contaminants, produce unique synergistic toxicity when co-existing. Key unanswered questions include specific effects on liver function and potential mechanisms.MethodsIn this study, C57BL/6 mice and AML12 cells were used to establish in vivo and in vitro models to elucidate the effects of combined exposure to PS-MPs and Cd on the liver and their mechanisms.ResultsThe results showed that the combined effects of PS-MPs and Cd caused significantly more liver damage than exposure alone. As observed by transmission electron microscopy (TEM), the number of autophagosomes was significantly increased in the PS-MPs and Cd co-treated group. In addition, autophagic flux was assayed by RFP-GFP-LC3, a reporter system expressing dual fluorescent proteins, which showed an overwhelming enhancement of autophagic flux damage by co-exposure to PS-MPs and Cd compared to exposure alone. To further investigate the involvement of carnitine palmitoyltransferase1(CPT1) in liver injury induced by co-exposure to Cd and PS-MPs, we co-exposed Baicalin, an activator of CPT1, with PS-MPs and Cd, and showed that activation of CPT1 alleviated the impairment of autophagic fluxes induced by co-exposure of Cd and PS-MPs and further alleviated the changes in lipid accumulation and associated protein levels.DiscussionIn conclusion, the concurrent exposure of PS-MPs and Cd resulted in the blockage of hepatic lipid accumulation and autophagic pathway and further aggravated the toxic damage to the liver. Activation of CPT1 could alleviate the PS-MPs and Cd-induced lipid accumulation and autophagy pathway blockage thus reducing liver injury.
Muscle power is associated with higher levels of walking capacity and self-reported gait performance and physical activity in individuals with cerebral palsy
Authors: Pontiff Mattie E. , Batra Abhinandan , Li Li , Moreau Noelle G. 
Published: January 2025

IntroductionThe purpose of this study was to investigate the relationships between a Power Leg Press test (PLP) with walking capacity and self-reported performance and participation in individuals with Cerebral Palsy (CP), and to compare the strength of the associations between two power tests (PLP and isokinetic (IsoK)) with walking capacity.MethodsAmbulatory individuals with CP (n = 33; age 17.89 ± 7.52 years) performed five inclined power leg presses at 40%–50% of their 1-repetition maximum “as fast as possible”. A linear position transducer was attached to the weight bar, and the displacement, total load, and angle of the sled were used to calculate peak power for each trial. Isokinetic knee extensor power was measured at 60 deg/sec. Walking capacity was measured using the 10-m walk test fast (FS) and self-selected (SS) speeds and the 1-min walk test (1MWT). Self-reported performance and participation measures were the Activities Scale for Kids-performance (ASKp), Patient-Reported Outcomes Measurement Information System (PROMIS®), and the Gait Outcomes Assessment List (GOAL). Pearson’s correlation coefficients determined relationships between power measures with walking capacity and self-report measures (α &lt; 0.05).ResultsPLP and IsoK power were significantly correlated to SS (r = 0.361, r = 0.376), FS (r = 0.511, r = 0.485), and 1MWT (r = 0.583. r = 0.443), respectively (p &lt; 0.05). There was no significant difference between the strength of the associations between walking capacity and each test of power (PLP and Isok) (p &gt; 0.05). PLP power was significantly correlated to composite scores on the ASKp (r = 0.690) and GOAL (r = 0.577) and to four components of the PROMIS, including physical function (r = 0.588) (p &lt; 0.01). The Gait and Mobility subscale of the GOAL (r = 0.705) and the Locomotion (r = 0.636), Transfers (r = 0.547), and Standing (r = 0.521) subscales of the ASKp had strong relationships to peak power produced during the PLP test (p &lt; 0.01).DiscussionPLP power was significantly correlated with walking capacity and self-reported walking performance and mobility-based participation in ambulatory individuals with CP. Higher movement velocities associated with the PLP test may explain the significant associations of power with faster gait speeds. Self-reported mobility performance and physical activity also showed moderate to strong relationships with lower extremity power. Overall, these results suggest a strong link between decreased muscle power generation and walking limitations in individuals with CP.
Children’s emerging concepts of resilience: insights from using body mapping in an East London cohort sample of 7-10-year-old children
Authors: Murray Aisling , Smith Scott Dominie Mahala , Nikolajeva Milena , Porricelli Daniele , van Loggerenberg Francois , Ougrin Dennis , Lau Jennifer Y. F. 
Published: January 2025

BackgroundUnderstanding resilience factors in children is essential for developing early mental health interventions. Middle childhood is an understudied developmental stage, with many quantitative measures lacking validation for this age group and not capturing diverse experiences. This study aimed to use body mapping, an arts-based method, as a novel approach to understand 7-10-year-old children’s concepts of resilience (including definitions and factors that contribute to resilience) in East London. An advisory group of six children commented on the findings.MethodsBody mapping was included in the Development of Emotional Resilience (DEER) Study. Participants drew a resilience symbol, wrote recent worries and colored on an A4-sized body map to signal where they embody stress. Demographic data were collected via self- and parent-report surveys and school records. Manifest content analysis identified four thematic categories related to worries, somatic stress and resilience.Results196 children (48.47% boys, 46.43% girls; 35.20% White, 30.10% Asian, 11.22% Black) across school years 3–5 completed body mapping. Concepts of resilience included perseverance and metaphorical representations of personal strength. We also identified socioecological factors that contributed to resilience, mainly at the individual and interpersonal levels. Boys more often depicted Sports whilst more girls depicted Engagement in the arts and Social networks. 11 worry categories emerged, including education, relationships and physical health. Of the body categories colored (n = 51), the most common were the head, hands and abdomen/stomach.ConclusionChildren expressed dominant and abstract symbols of resilience and identified factors that contributed to resilience. Hobbies and strong relationships may be particularly important in middle childhood, corroborated by the advisory group’s experiences. Body mapping revealed diverse worries (e.g., education, change and uncertainty and global and societal concerns) and somatic experiences of stress (e.g., the head, chest and torso). Through prioritising children’s perspectives, body mapping holds promise in clinical and educational settings.