bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor Necrosis Factor Alpha -308G/A Gene Polymorphisms Combined with Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio Predicts the Efficacy and Safety of Anti-TNF-α Therapy in Patients with Ankylosing Spondylitis, Rheumatoid Arthritis, and Psoriasis Arthritis
Authors: Wang Ziran , Kong Lingjun , Zhang Han , Sun Fengchun , Guo Zijian , Zhang Rui , Dou Yaling 
Published: January 2022

Background: TNF-α has been reported to be closely associated with autoimmune inflammatory diseases. This study aims to investigate the role of TNF-α -308(rs1800629) G/A gene polymorphisms as well as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting the efficacy and safety of TNF inhibitors (TNFi) in patients with ankylosing spondylitis (AS), rheumatoid arthritis (RA), and psoriasis arthritis (PsA).Methods: A total of 515 subjects (181 AS, 144 RA, 48 PsA, 10 hyperbilirubinemia, 10 hyperlipidemia and 122 healthy control) were recruited in this study. The accuracy of RT-PCR methods for identifying individual TNF-α -308 genotypes was assessed using sequencing as the gold standard. Baseline NLR and PLR of patients with AS, RA and PsA and healthy controls (HC) were calculated and compared. Meanwhile, differences between responders and non-responders to TNFi treatment as well as between individuals with and without adverse effects (AE) among responders were compared.Results: The RT-PCR method is stable and reliable for TNF-α -308G/A gene polymorphism analysis, independent of sample status. The GG genotype was overwhelmingly represented, with relatively few GA genotype, whilst the AA genotype was not detected in this study. There was no observed association between TNF-α-308G/A polymorphism and susceptibility in AS, RA or PsA patients. Patients with AS, RA, and PsA had a higher NLR, compared to the HC group. Apart from PsA patients, AS and RA patients had a higher PLR, compared to the HC group. NLR was positively correlated with PLR. Furthermore, a lack of response was more frequently observed in AS and RA patients that carrying the GA genotype than the GG genotype. AS and RA patients with AE had higher NLR and PLR, compared with the non-AE group.Conclusion: Our study preliminarily shown that combining TNF-α -308G/A polymorphisms with NLR and PLR can predict the responsiveness and safety of anti-TNF therapy in patients with AS or RA.
PRÁTICAS DE LEITURA COMO RECURSO DIDÁTICO NO ENSINO DA HISTÓRIA LOCAL
Authors: Nascimento Ricardo Rodrigues , Cavalcanti Givaldo , Bueno João Batista Gonçalves 
Published: January 2022

O presente artigo partiu da verificação de que os estudantes do ensino fundamental da Escola Estadual de Ensino Fundamental Professor Rangel (Ingá-PB) têm dificuldades de leitura e escrita. Por outro lado, entendemos que o estudo dos conteúdos históricos, realizado pela disciplina de História, contribuiu para a melhora das condições de ensino dessa escola básica. Por meio do estudo dessa área de conhecimento, pode-se produzir ações de leitura que estabeleceram relações entre fatos que ocorrem no presente com os ocorridos no passado. Entendemos que o processo de contextualização no cotidiano dos alunos na relação com as narrativas de memórias possibilitou, também o surgimento de práticas de leitura criadoras e inventivas, as quais tiveram um caráter multidimensional. Em relação aos aportes teóricos que utilizamos para o desenvolvimento desta pesquisa, destacam-se as concepções dos seguintes autores: W. Benjamin; José Carlos Reis; Maria Carolina B. Galzerani e Circe Bittencourt. Palavras-chave: Ensino de História. Leitura. Narrativas de memória.
Analysis of MSME Players of Creative Economy Culinary Subsector in Bengkalis City
Authors: Ningsih Julia , Junita Raflah Wan 
Published: January 2022

This study aims to determine what Kinds of Culinary ,characteristics ,creativity, and the Structure-Conduct-Performance (SCP) approach. This study used a qualitative descriptive method with the object of research on MSME players. The sampling technique of this study used a stratified random sample method with a total of 40 samples. Data collection techniques in this study using documentation and interview methods. The results of this study 50% of MSME players are 41-50 years old, 47,5% MSME players have a high school background as their last education, 27.5% have been in business for 1-2 years. Based on the SCP approach, the culinary business model in Bengkalis City is independent, MSME players in Bengkalis City set prices looking at price information from competitors, in promotion tools 75% of MSME players put in stalls and the performance of MSME players is 32.5% monthly income ranges from IDR 2.000.000 - IDR 5.000.000
REDESAIN SALURAN DRAINASE DENGAN EFISIENSI BALOK MELINTANG (Studi Kasus Proyek Peningkatan Jalan Bengkalis - Perapat Tunggal (Dak))
Authors: Sahru Iis , Alamsyah Alamsyah , Tifani Efan 
Published: January 2022

Banyak saluran drainase yang telah dibangun di Kabupaten Bengkalis. Salah satunya adalah proyek perbaikan jalan pada jalan Bengkalis menuju ke PerapatTunggal, saluran drainasenya dirancang dengan skor balok melintang yang rapat sementara beban yang ditahan hanya beban tekanan tanah, sedikit beban matidan beban hidup. Untuk mengetahui tekanan tanah samping pada saluran dilakukan uji hand-boring. Perhitungan beton bertulang dilakukan setelahmendapatkan gaya dalam akibat beban. Perhitungan struktur mengacu ke SNI 03-2847-2002. Dari perhitungan balok melintang yang dibebani beban sentris,diperoleh gaya aksial (Pu) 227,05 kN. Sedangkan dari pemodelan dan analisis balok dengan menggunakan SAP2000 menggunakan tekanan tanah, didapat nilaigaya axial sebesar 9,796 kN dengan jarak 2,5 m. Dari hasil ini dapat disimpulkandengan jarak balok melintang 2,5 meter sangat aman.Perhitungan skor balokdengan jarak 5 m, balok masih aman dengan Pu 19,462 kN.
PENENTUAN JENIS TIKUNGAN DAN EVALUASI GEOMETRIK JALAN STUDI KASUS : JALAN TANJUNG KAPAL – DARUL AMAN KECAMATAN RUPAT
Authors: Aldi M. Hafis , Idham Muhammad 
Published: January 2022

Pembangunan jalan akan dilakukan di jalan desa Tanjung Kapal menuju Darul Aman Kecamatan Rupat Kabupaten Bengkalis merupakan akses masyarakat untuk menjalani aktivitas perkebunan, perekonomian, dan pendidikan dengan panjang jalan 11,2 km dan terdapat 15 tikungan. pembangunan ini dilakukan melalui dana alokasi khusus (DAK) Kabupaten Bengkalis. Perhitungan dan analisis geometrik ini menggunakan TPGJAK 1997 dengan menanalisis alinyemen horizontal jalan sesuai dengan kondisi lapangan.Hasil analisis dan evaluasi geometrik jalan dengan panjang 11,2 Km dengan kecepatan rencana 70 km/jam dan lebar jalan 6meter, didapatkan bahwa 11 tikungan Spiral – Circle – Spiral (S-C-S) dan 4 tikungan termasuk kedalam tikungan Full Circle (F-C) dengan superelevasi maksimum : T1=8%, T2=6.7%, T3=7%, T4=8.7%, T5=7.5%, T6=9.5%, T7=7.7%, T8=7.3%, T9=7.2%, T10=7.5%, T11=8.5%, T12=6.7%, T13=7.5%, T14=7.6%, T15=7%, jarak pandang henti didapatkan 51.35 meter, jarak pandang menyiap didapatkan 421.95 meter.
Kajian Literatur Uji Aktivitas Antikanker Payudara Tanaman Ranti (Solanum nigrum Linn.) Secara in vitro dan in vivo
Authors: Nurmaulawati Rina 
Published: January 2022

Pengujian in vitro dan in vivo adalah serangkaian uji yang dilakukan untuk menentukan apakah suatu produk layak, berkhasiat, dan aman digunakan sebagai obat. Kajian literatur ini bertujuan memberikan sistematik review aktivitas antikanker payudara (Solanum nigrum L.) meliputi bagian tanaman, pelarut, cara ekstraksi, serta mekanisme molekuler zat aktif secara in vitro dan in vivo. Metode kajian literatur adalah metode prisma dengan tahapan penentuan topik, penentuan rumusan masalah, pengumpulan data dari jurnal penelitian hasil penelusuran melalui google scholar dengan kata kunci cytotoxicity Solanum nigrum L. as anti-breast cancer in vitro and in vivo, menganalisis data dalam bentuk kelompok tabel, mengekstraksi data sesuai kriteria inklusi dan menarik kesimpulan sesuai rumusan masalah. Daun, batang, buah matang, buah mentah dengan ekstraksi, perkolasi, dan shokletasi menggunakan pelarut air, etanol, n-heksan, dan etil asetat memiliki aktivitas antikanker payudara. Senyawa dan golongan senyawa aktif yang berperan sebagai antikanker payudara pada Solanum nigrum L. adalah alkaloid, steroid, flavonoid, tanin, karbohidrat, dan saponin, polisakarida rhamnosa, glukosa dan galaktosa, fenolik, kumarin, asam gentisik, luteolin, apigenin, kaempferol, m- asam kumarat, antosianidin, alfa solanin. Mekanisme molekuler zat aktif ekstrak Solanum nigrum L. sebagai agen kemoterapi diantaranya sebagai antioksidan, menginduksi apoptosis, menginhibisi proliferasi, dan menstimulasi respon imun, menginduksi aktivitas fagositosis. Kata kunci : Antikanker payudara, Solanum nigrum L., in vitro in vivo.
The Relation of Maxim Flouting Used to Illocutionary Function of Politeness in 12 Years a Slave Movie
Authors: Anjani Zain Nabilah , Jepri Jepri , Hafsah Siti 
Published: January 2022

This research explores types of maxim flouting in 12 Years A Slave’s Movie and aims to identify the types of maxim flouting in 12 Years A Slave movie and to seek out the relation of maxim flouting to the illocutionary function of politeness. The pragmatic analysis using H. P. Grice’s theory of maxim flouting is used with descriptive methodology. The movie scripts were taken as the primary data. Researcher found that there are four types of maxim flouting performed by Solomon Northup; and the relation of maxim flouting to the illocutionary function of politeness are competitive, collaborative, convivial, and conflictive.
PENGARUH MODAL INTELEKTUAL TERHADAP KINERJA PERUSAHAAN PADA INDUSTRI DASAR DAN KIMIA
Authors: Veronica M. Sienly , Ida Ida , Joseph Syano 
Published: January 2022

Riset ini bermaksud menganalisis pengaruh modal intelektual berdasarkan VACA, VAHU, dan STVA terhadap kinerja keuangan perusahaan. Gaya penentuan sampel yang dipergunakan yakni non probabilistic sampling dengan jenis purposive sampling sehingga terdapat 46 perusahaan yang ada pada kelompok industri dasar dan kimia yang terdaftar di BEI yang akan digunakan sebagai sampel sedangkan analisis data yang digunakan untuk menjawab hipotesis penelitian adalah korelasi Pearson. Hasil penelitian menunjukkan bahwa modal intelektual yang terdiri dari VACA, VAHU dan STVA tidak memiliki korelasi terhadap kinerja keuangan perusahaan yang diukur dengan menggunakan rasio return on assets (ROA). Tidak adanya korelasi antara modal intelektual dan kinerja keuangan perusahaan dikarena perusahaan belum maksimal dalam memberdayakan dan mengelola aset-aset perusahaan baik yang bersifat tangible assets maupun intangible assets sehingga diharapkan perusahaan dapat lebih memberdayakan aset yang dipunyai oleh perusahaan dengan memberikan pelatihan-pelatihan yang bervariasi kepada karyawan sesuai dengan kompentensi karyawan, mengadopsi teknologi terbarukan agar perusahaan dapat terus kreatif dalam memproduksi produk yang sesuai dengan keinginan dan kebutuhan konsumen dan perusahaan terus mengkomunikasikan nilai-nilai perusahaan kepada semua orang yang terlibat dalam perusahaan untuk dapat meningkatkan kinerja keuangan perusahaan sehingga kinerja perusahaan dapat ditingkatkan pada akhirnya.
DIGITAL TEACHING OF RUSSIAN AS A FOREIGN LANGUAGE IN THE PARADIGM OF CREATIVE INDUSTRIES (INTERCULTURAL SPECIFICITY)
Authors: Барышников А.А. , Трофимова Г.Н. 
Published: January 2022

Статья рассматривает основания и предпосылки нового подхода к преподаванию РКИ в цифровом формате. Авторы выявляют внутренние взаимосвязи между основными принципами межкультурной коммуникации и эмоционального интеллекта в аспекте креативных индустрий и определяют преимущества такого подхода для создания эффективных программ обучения на цифровой платформе для мобильных устройств.
The article examines the foundations and prerequisites for a new approach to teaching Russian as a foreign language in digital format. The authors identify the internal relationships between the basic principles of intercultural communication and emotional intelligence in the aspect of creative industries and determine the benefits of this approach for creating effective learning programs on a digital platform for mobile devices.
TEACHING RUSSIAN AS A FOREIGN LANGUAGE (RFL) IN THE CONTINUOUS EDUCATION SYSTEM OF THE REPUBLIC OF UZBEKISTAN
Authors: Насиров А.А. 
Published: January 2022

В статье представлен новый подход к обучению русскому языку в Узбекистане. Ранее основным был подход, в котором русский язык преподавался как неродной, в настоящее время происходит переход к преподаванию русскому языку как иностранному. Описываются факторы необходимости изменения рабочих программ по русскому языку, а также создание новых концепций преподавания РКИ в Узбекистане.
This article deals with a new approach to teaching the Russian language in Uzbekistan, which is called «Russian as a foreign language». Initially, the country had a method of teaching RRC, now they are moving into the method of teaching Russian as foreign language. The factors of the need to change work programs in the Russian language are described, as well as the creation of new concepts of teaching the Russian language in Uzbekistan.
Extracurricular activities as a means of forming of cross-cultural competence of foreign students (the experience of Theater studio in Shenzhen MSU-BIT University)
Authors: Мареева Ю.А. , Марченко О.С. 
Published: January 2022

Обучение иностранцев русскому языку в отсутствие языковой среды требует от преподавателя дополнительных усилий по созданию условий и благоприятной атмосферы не только в ходе занятий, но и во внеурочное время. Один из эффективных способов увлечь студентов и мотивировать их общаться на русском языке после уроков – кружок «Театральная студия». В статье описан успешный опыт работы такой студии в совместном Университете МГУ-ППИ в Шэньчжэне (КНР). Студенты начального этапа обучения участвовали в подготовке спектаклей и с большим энтузиазмом представляли все, чему успели научиться, на сцене, где в полной мере проявлялся их творческий потенциал. При подготовке к постановке пьесы на сцене, разучивании ролей иностранные учащие-ся расширяют свой словарный запас, узнают больше о русской культуре и жизни русских людей. Таким образом они вовлекаются в межкультурный диалог, что повышает их мотивацию к дальнейшему изучению русского языка. Работа над общим проектом в сплоченной команде помогает справляться с трудностями, возникающими во время учебы, делает студентов более уверенными в своих силах.
Teaching Russian as a Foreign Language abroad far from language environment and without natural immersion acquires from educator additional efforts to create appropriate conditions and positive atmosphere not only during the lessons but also during extracurricular activities. One of effective ways to attract students’ attention and motivate them to communicate in Russian language after the classes is a theatre studio. The paper describes successful experience of a theatre club in joint MSU-BIT University in Shenzhen (People’s Republic of China). Beginners in Russian language very enthusiastically participated in performances and presented all that they had learnt on the University’s scene where they could fully realize their creative potential. By preparing the performance, learning texts and dialogues by heart foreign students enhance their vocabulary, learn more about Russian culture and Russian people’ lives. Such activity draws the students into cross-cultural communication, increases their motivation to further studying of Russian language. The interaction in the united team and working on a joint project help students to overcome difficulties appearing during their studies, make students to feel more self-assured.
Specialty language training and a new stage in the development of Russian-Chinese cooperation in the field of training organization
Authors: Ван Ли. , Цыренова М.И. 
Published: January 2022

Значение сотрудничества России и Китая в сфере организации обучения становится все более важным инструментом в развитии отношений между странами и приобретает широкие перспективы. В этом процессе обучение русскому языку играет незаменимую роль. В связи с этим в настоящее время возникла необходимость в реформе преподавания русского языка на территории Китая, усилении интеграции профессионального обучения и преподавания русского языка общего владения, изучении методов преподавания языка специальности, укреплении основ языковой работы в организации обучения, реализующей российско-китайское сотрудничество, а также в подготовке специалистов высокого уровня. В статье рассматриваются цели обучения в российско-китайских совместных учебных заведениях и способы их достижения. Отмечается, что следует большее внимание уделить формированию навыков использования языка специальности, в том числе для удовлетворения актуальных потребностей учащихся по программе «специальность + язык».
The importance of cooperation between Russia and China in the field of organizing training is becoming an increasingly important tool in the development of relations between the countries and is gaining wider prospects. At the same time, teaching Russian plays an irreplaceable role. In this regard, there is now a need for a reform of the teaching of the Russian language in China, there was a need to strengthen the integration of professional training and teaching of the Russian language of general proficiency, to study the methods of teaching specialty language, to strengthen the foundations of language work in the organization of training that implements Russian-Chinese cooperation, to train high-level specialists. The article discusses the goals of studying in Russian-Chinese joint educational institutions and ways to achieve them. It is noted that more attention should be paid to the formation of skills in using specialty language, including to meet the actual needs of students under the specialty + language program.
«Bibliography of V.G. Kostomarov published works»: work on the book and its presentation. BIBLIOGRAPHY OF V.G. KOSTOMAROV / COMP. V.I. ANNUSHKIN, A.G. ZHUKOVA. M.: FLINT; GOS. IRYA THEM. A.S. PUSHKINA, 2021. – 100 pp.
Authors: Аннушкин В.И. , Жукова А.Г. 
Published: January 2022

В статье представлены основная идея и организация работы над первой обобщающей книгой о творчестве академика В.Г. Костомарова. Книга, начатая кратким очерком о жизни и научно-педагогической деятельности основателя Института русского языка имени А.С. Пушкина, содержит самый полный список публикаций ученого: 617 работ, опубликованных с 1953 по 2020 г. В статье приведены критические оценки книги авторитетных русистов, высказавших на презентации книги мнения о перспективах работы по изучению наследия В.Г. Костомарова.
The article presents the main idea and organization of work on the first generalizing book about the work of Academician V.G. Kostomarov. The book, which began with a short essay on the life and scientific and pedagogical activities of the founder of the A.S. Pushkin, contains the most complete list of the scientist's publications: 617 works published in the period from 1953 to 2020. The article provides critical assessments of the book by authoritative Russian scholars who, at the presentation of the book, expressed their views on the prospects for studying the heritage
Floristic survey of vascular plants of a poorly known area in the Brazilian Atlantic Forest (Flona do Rio Preto, Espírito Santo)
Authors: Alves-Araújo Anderson , Moreira Marina , Carrijo Tatiana , Lohmann Lúcia , Lobão Adriana , Scheidegger Alana , Firmino Aline , de Melo Silva Aline , Nepomuceno Álvaro , Tuler Amélia , Amorim André , Moreira André , Cosenza Braz , Sossai Brenno , Silva Christian , Lopes Claudia , Monteiro Daniele , Couto Dayvid , Lima Duane , Dalcin Eduardo , Ramos Eliana , Lírio Elton , Salimena Fatima , de Oliveira Felipe , Fraga Fernanda , Torres-Leite Filipe , Antar Guilherme , Shimizu Gustavo , Lima Haroldo , Medeiros Herison , Luber Jaquelini , Christ Jheniffer , Lanna João , Zorzanelli João Paulo , Freitas Joelcio , Pastore José , Melo José , Paula-Souza Juliana , Oliveira Juliana , Pederneiras Leandro , Freitas Leandro , Giacomin Leandro , Meireles Leonardo , Silva Luis , Pinto Luiz , Menini Neto Luiz , Trovó Marcelo , Garbin Mário , Morim Marli , Ribeiro Michel , Pena Nelson , Labiak Paulo , Cardoso Pedro , Viana Pedro , Moraes Pedro , Moraes Quélita , Zorzanelli Raquel , Amaral Renara , Asprino Renata , Goldenberg Renato , Magnago Ricardo , Couto Ricardo , Dutra Sandrine , Hoyos-Gómez Saúl , Vieira Tamara , Flores Thiago , Dutra Valquíria , Miranda Víctor , Manhães Vitor , Forzza Rafaela 
Published: January 2022

The Atlantic Forest is one of the most threatened biomes in the world. Despite that, this biome still includes many areas that are poorly known floristically, including several protected areas, such as the "Floresta Nacional do Rio Preto" ("Flona do Rio Preto"), located in the Brazilian State of Espírito Santo. This study used a published vascular plant species list for this protected area from the "Catálogo de Plantas das Unidades de Conservação do Brasil" as the basis to synthesise the species richness, endemism, conservation and new species occurrences found in the "Flona do Rio Preto".
The published list of vascular plants was based on field expeditions conducted between 2018 and 2020 and data obtained from herbarium collections available in online databases. Overall, 722 species were documented for the "Flona do Rio Preto", 711 of which are native to Brazil and 349 are endemic to the Atlantic Forest. In addition, 60 species are geographically disjunct between the Atlantic and the Amazon Forests. Most of the documented species are woody and more than 50% of these are trees. Twenty-three species are threatened (CR, EN and VU), while five are Data Deficient (DD). Thirty-two species are new records for the State of Espírito Santo. Our results expand the knowledge of the flora of the Atlantic Forest and provide support for the development of new conservation policies for this protected area.