bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stress transmission along mid-crustal faults highlighted by the 2021 Mw 6.5 San Juan (Argentina) earthquake
Authors: Ammirati Jean-Baptiste , Mackaman-Lofland Chelsea , Zeckra Martin , Gobron Kevin 
Published: October 2022

AbstractUnderstanding the mechanisms of crustal deformation along convergent margins is critical to identifying seismogenic structures and assessing earthquake hazards for nearby urban centers. In the southern central Andes (28–33$$^{\circ }$$∘S), differences in the style of middle to upper-crustal deformation and associated seismicity are highlighted by the January 19th, 2021 (Mw 6.5) San Juan earthquake. We integrate waveforms recorded at regional and teleseismic distances with co-seismic displacements calculated from local Global Navigation Satellite System time series, to re-estimate the source parameters of the 2021 San Juan earthquake, confirming a mid-crustal nucleation depth (21 ± 2 km) and right-lateral transpressional mechanism. Considered alongside decades of seismic observations and geological data, this event provides evidence for retroarc deformation partitioning among inherited basement faults and upper-crustal structures in response to oblique convergence of the Nazca and South American plates. As they may transfer shortening to active upper-crustal faults associated with historically devastating shallower earthquakes, a better understanding of seismogenic basement faults such as the mid-crustal structure activated during the 2021 San Juan earthquake earthquake could help future re-assessment of the seismic risk in western Argentina.
Expression level of the reprogramming factor NeuroD1 is critical for neuronal conversion efficiency from different cell types
Authors: Matsuda-Ito Kanae , Matsuda Taito , Nakashima Kinichi 
Published: October 2022

AbstractSeveral transcription factors, including NeuroD1, have been shown to act as neuronal reprogramming factors (RFs) that induce neuronal conversion from somatic cells. However, it remains unexplored whether expression levels of RFs in the original cells affect reprogramming efficiency. Here, we show that the neuronal reprogramming efficiency from two distinct glial cell types, microglia and astrocytes, is substantially dependent on the expression level of NeuroD1: low expression failed to induce neuronal reprogramming, whereas elevated NeuroD1 expression dramatically improved reprogramming efficiency in both cell types. Moreover, even under conditions where NeuroD1 expression was too low to induce effective conversion by itself, combined expression of three RFs (Ascl1, Brn2, and NeuroD1) facilitated the breaking down of cellular barriers, inducing neuronal reprogramming. Thus, our results suggest that a sufficiently high expression level of RFs, or alternatively their combinatorial expression, is the key to achieving efficient neuronal reprogramming from different cells.
The fear of conflict leads people to systematically avoid potentially valuable zero-sum situations
Authors: Davidai Shai , White Michael W. , Gregorich Genevieve 
Published: October 2022

AbstractFrom interpersonal interactions to international arms races, game theorists and social scientists have long studied decision-making in zero-sum situations. Yet, what happens when people can freely choose whether to enter zero-sum situations in the first place? Thirteen studies (including five pre-registered) consistently document evidence for zero-sum aversion—the desire to avoid situations that are (or are believed to be) zero-sum. Across different contexts (economic games, market entry decisions, performance reviews, negotiations, job applications), samples (online participant pool, MBA students, community sample), and designs (within- and between-participant, real and hypothetical decisions), people avoid zero-sum situations that inversely link their and others’ outcomes as well as refrain from putting others in such situations. Because people fear that zero-sum situations will be rife with conflict, they exhibit zero-sum aversion even when doing so is costly. Finally, we find that people require zero-sum situations to provide substantially higher payoffs (e.g., compensation) to overcome their zero-sum aversion. We conclude with a discussion of the implications for interpersonal and intergroup conflict.
Efficacy of cabazitaxel and androgen splicing variant-7 status in circulating tumor cells in Asian patients with metastatic castration-resistant prostate cancer
Authors: Ashizawa Takeshi , Nagata Masayoshi , Nakamura So , Hirano Hisashi , Nagaya Naoya , Lu Yan , Horie Shigeo 
Published: October 2022

AbstractAndrogen receptor splice variant-7 (AR-V7) expression in circulating tumor cells (CTCs) in metastatic castration-resistant prostate cancer (mCRPC) is associated with abiraterone and enzalutamide resistance. We determine whether cabazitaxel (CBZ) is equally effective in AR-V7-positive and -negative CRPC and whether AR-V7-positive patients retain CBZ sensitivity. This is the first prospective, open-label, Asian validation study of CBZ in Japanese patients with mCRPC after docetaxel (n = 48; four CBZ cycles; 2017–2020, Juntendo University Hospitals). Primary endpoint was prostate-specific antigen response rate (PSA-RR); secondary endpoints included overall survival (OS), bone scan index (BSI) PSA-RR (≥ 50% decline from baseline) for CTC−/ARV7−, CTC+ /ARV7−, and CTC +/ARV7+ groups. PSA-RR ≥ − 30% was 38% (18/48) and ≥ − 50% was 26% (12/48). BSI-change rate ≥ − 30% was 19% (9/41) and ≥ − 50% was 17% (8/41). Median OS was 13.7(12.2–18.9) months. PSA decline in early CBZ treatment associated with OS (p = 0.00173). BSI decline associated with OS (p = 0.0194). PSA-RR(≥ 50%) was 43%(6/14) in CTC−/ARV7−, 19%(5/26) in CTC+ ARV7−, and 12%(1/8) in CTC+/ARV7+ (p > 0.05). AR-V7 in CTCs at baseline not associated with OS. AR-V7 was not associated with CBZ resistance in CTCs. Reductions in BSI and PSA in early stages of CBZ treatment may predict OS.
Construction and experimental verification of the spatial attitude kinematic model of advanced support equipment
Authors: Chen Hanzhao , Zhang Kun , Sun Zhengxian , Hu Chengjun , Li Yuxia , Wei Xuntao , Du Mingchao , Liu Ya , Wang Xin 
Published: October 2022

AbstractThe roadway in coal mine is prone to deformation of the surrounding rock under the influence of complex disturbance, which induces the imbalance of support attitude matching between roadway surrounding rock and advanced coupling support equipment, breaks the mechanical balance of the original coupling support system, and causes safety accidents. The postures and offsets of the various working spaces of the advanced hydraulic supports under the influence of complex disturbances are systematically analyzed. The D–H parameter matrix transformation method is used to establish the spatial posture kinematic model of a single/group of advanced hydraulic supports. The posture parameters of each key node are obtained through global coordinate transformation. Based on the comparison of the working attitude parameters of the support obtained through simulation analysis and model calculation, the average absolute error of the support height calculation results of the single group of advanced hydraulic support attitude model is 3.92 mm, and that of the coordinate calculation results of the advanced hydraulic support group is (3.26 mm, 1.99 mm), which meet the accuracy requirements of the advanced hydraulic support attitude monitoring. Finally, the spatial attitude kinematic model of a single/group of advanced hydraulic supports is verified and analyzed by using the advanced hydraulic support attitude monitoring test bench. The maximum error value of the experimental results is 4.9 mm, which verifies the accuracy of the established spatial attitude kinematic model of the advanced hydraulic support. The research results can provide theoretical and technical support for the intelligentization of the advanced coupling support system and the safe and efficient mining of coal mine.
Herbicide spray drift from ground and aerial applications: Implications for potential pollinator foraging sources
Authors: Butts Thomas R. , Fritz Bradley K. , Kouame K. Badou-Jeremie , Norsworthy Jason K. , Barber L. Tom , Ross W. Jeremy , Lorenz Gus M. , Thrash Benjamin C. , Bateman Nick R. , Adamczyk John J. 
Published: October 2022

AbstractA field spray drift experiment using florpyrauxifen-benzyl was conducted to measure drift from commercial ground and aerial applications, evaluate soybean [Glycine max (L.) Merr.] impacts, and compare to United States Environmental Protection Agency (US EPA) drift models. Collected field data were consistent with US EPA model predictions. Generally, with both systems applying a Coarse spray in a 13-kph average wind speed, the aerial application had a 5.0- to 8.6-fold increase in drift compared to the ground application, and subsequently, a 1.7- to 3.6-fold increase in downwind soybean injury. Soybean reproductive structures were severely reduced following herbicide exposure, potentially negatively impacting pollinator foraging sources. Approximately a 25% reduction of reproductive structures up to 30.5-m downwind and nearly a 100% reduction at 61-m downwind were observed for ground and aerial applications, respectively. Aerial applications would require three to five swath width adjustments upwind to reduce drift potential similar to ground applications.
Optimization method and experimental research on attitude adjustment scheme of attitude adaptive rescue robot
Authors: Wang Shipeng , Pan Dewei , Zhou Zhaoxin , Yu Haochen , Ma Xushi , Fang Guanqing 
Published: October 2022

AbstractTo improve the space attitude adjustment efficiency of the robot designed in this study, the average water level height variation of each ballast tank during the rescue process and the ballast water filling mass before the rescue process are taken as optimization variables, the minimal ballasting time during rescue process as the optimisation objective, and the heel and trim inclination angle, and stability in the rescue process as the constraint conditions. For the first time, an optimization method of a rescue robot space attitude adjustment scheme based on a dynamic programming algorithm is proposed. Relevant experiments and data collection were carried out with a model robot with a physical ratio of 1:2. MATLAB simulation and model robot experimental results show that compared with an empirical scheme, the total deployment time and ballast water total allocation mass are reduced by 11.07% and 30.79%, respectively, and the heel and trim angle variation stability is increased by 4.18% and 8.67%, respectively. The optimization model and algorithm are beneficial to improve the space attitude adjustment efficiency and stability of the rescue robot in this paper, and it is also easier to transfer to other fields of ballast water allocation, which has strong practical engineering significance.
Simulation of a machine learning enabled learning health system for risk prediction using synthetic patient data
Authors: Chen Anjun , Chen Drake O. 
Published: October 2022

AbstractWhen enabled by machine learning (ML), Learning Health Systems (LHS) hold promise for improving the effectiveness of healthcare delivery to patients. One major barrier to LHS research and development is the lack of access to EHR patient data. To overcome this challenge, this study demonstrated the feasibility of developing a simulated ML-enabled LHS using synthetic patient data. The ML-enabled LHS was initialized using a dataset of 30,000 synthetic Synthea patients and a risk prediction XGBoost base model for lung cancer. 4 additional datasets of 30,000 patients were generated and added to the previous updated dataset sequentially to simulate addition of new patients, resulting in datasets of 60,000, 90,000, 120,000 and 150,000 patients. New XGBoost models were built in each instance, and performance improved with data size increase, attaining 0.936 recall and 0.962 AUC (area under curve) in the 150,000 patients dataset. The effectiveness of the new ML-enabled LHS process was verified by implementing XGBoost models for stroke risk prediction on the same Synthea patient populations. By making the ML code and synthetic patient data publicly available for testing and training, this first synthetic LHS process paves the way for more researchers to start developing LHS with real patient data.
A long noncoding RNA HILinc1 enhances pear thermotolerance by stabilizing PbHILT1 transcripts through complementary base pairing
Authors: Zhang Yi , Wang Shengnan , Li Wei , Wang Shengyuan , Hao Li , Xu Chaoran , Yu Yunfei , Xiang Ling , Li Tianzhong , Jiang Feng 
Published: October 2022

AbstractAs global warming intensifies, heat stress has become a major environmental constraint threatening crop production and quality worldwide. Here, we characterize Heat-induced long intergenic noncoding RNA 1 (HILinc1), a cytoplasm-enriched lincRNA that plays a key role in thermotolerance regulation of pear (Pyrus spp.). HILinc1 Target 1 (PbHILT1) which is the target transcript of HILinc1, was stabilized via complementary base pairing to upregulate its expression. PbHILT1 could bind to Heat shock transcription factor A1b (PbHSFA1b) to enhance its transcriptional activity, leading to the upregulation of a major downstream transcriptional regulator, Multiprotein bridging factor 1c (PbMBF1c), during heat response. Transient overexpressing of either HILinc1 or PbHILT1 increases thermotolerance in pear, while transient silencing of HILinc1 or PbHILT1 makes pear plants more heat sensitive. These findings provide evidences for a new regulatory mechanism by which HILinc1 facilitates PbHSFA1b activity and enhances pear thermotolerance through stabilizing PbHILT1 transcripts.
Intron turnover is essential to the development and pathogenicity of the plant pathogenic fungus Fusarium graminearum
Authors: Choi Yejin , Lee Hyun-Hee , Park Jiyeun , Kim Sieun , Choi Soyoung , Moon Heeji , Shin Jiyoung , Kim Jung-Eun , Choi Gyung Ja , Seo Young-Su , Son Hokyoung 
Published: October 2022

AbstractIntron lariats excised during the splicing process are rapidly degraded by RNA lariat debranching enzyme (Dbr1) and several exonucleases. Rapid turnover of lariat RNA is essential to cellular RNA homeostasis. However, the functions of Dbr1 have not been investigated in filamentous fungi. Here, we characterized the molecular functions of Dbr1 in Fusarium graminearum, a major fungal plant pathogen. Deletion of FgDBR1 resulted in pleiotropic defects in hyphal growth, conidiation, sexual reproduction, and virulence. Through transcriptome analysis, we revealed that the deletion mutant exhibited global accumulation of intron lariats and upregulation of ribosome-related genes. Excessive accumulation of lariat RNA led to reduced overall protein synthesis, causing various phenotypic defects in the absence of FgDBR1. The results of this study demonstrate that a compromised intron turnover process affects development and pathogenesis in this fungus and that Dbr1 function is critical to plant pathogenic fungi.
Intramolecular charge-transfer enhances energy transfer efficiency in carotenoid-reconstituted light-harvesting 1 complex of purple photosynthetic bacteria
Authors: Yukihira Nao , Uragami Chiasa , Horiuchi Kota , Kosumi Daisuke , Gardiner Alastair T. , Cogdell Richard J. , Hashimoto Hideki 
Published: October 2022

AbstractIn bacterial photosynthesis, the excitation energy transfer (EET) from carotenoids to bacteriochlorophyll a has a significant impact on the overall efficiency of the primary photosynthetic process. This efficiency can be enhanced when the involved carotenoid has intramolecular charge-transfer (ICT) character, as found in light-harvesting systems of marine alga and diatoms. Here, we provide insights into the significance of ICT excited states following the incorporation of a higher plant carotenoid, β-apo-8′-carotenal, into the carotenoidless light-harvesting 1 (LH1) complex of the purple photosynthetic bacterium Rhodospirillum rubrum strain G9+. β-apo-8′-carotenal generates the ICT excited state in the reconstituted LH1 complex, achieving an efficiency of EET of up to 79%, which exceeds that found in the wild-type LH1 complex.
Quantum light transport in phase-separated Anderson localization fiber
Authors: Demuth Alexander , Camphausen Robin , Cuevas Álvaro , Borrelli Nick F. , Seward Thomas P. , Lamberson Lisa , Koch Karl W. , Ruggeri Alessandro , Madonini Francesca , Villa Federica , Pruneri Valerio 
Published: October 2022

AbstractPropagation of light by Anderson localization has been demonstrated in micro-nano-structured fibers. In this work, we introduce a phase separated glass Anderson localization optical fiber for quantum applications. By using a spontaneous parametric down-conversion source, multi-photon detection with a single-photon avalanche diode array camera, and signal post-processing techniques, we demonstrate quantum light transport, where spatial correlations between photon pairs are preserved after propagation. In order to better understand and improve light transport, we study light localization, observing a dependence on wavelength. Our results indicate that the proposed phase separated fiber may become an effective platform for quantum imaging and communication.
Novel porous organic polymers functionalized by metalloporphyrin and phosphonium salts for the efficient synergistic catalysis of CO2 conversion under mild conditions
Authors: Dai Zhifeng , Wang Shiting , Zhou Ning , Liu Yuxia , Xiong Yubing 
Published: October 2022

Metalloporphyrin- and phosphonium-functionalized porous organic polymers (POPs) were fabricated successfully via a post-synthesis modification strategy, which were demonstrated to be efficient heterogeneous catalysts for CO2 conversion.
Tryptophan metabolism and disposition in cancer biology and immunotherapy
Authors: Badawy Abdulla A.-B. 
Published: October 2022

Abstract
Tumours utilise tryptophan (Trp) and its metabolites to promote their growth and evade host defences. They recruit Trp through up-regulation of Trp transporters, and up-regulate key enzymes of Trp degradation and down-regulate others. Thus, Trp 2,3-dioxygenase (TDO2), indoleamine 2,3-dioxygenase 1 (IDO1), IDO2, N′-formylkynurenine formamidase (FAMID) and Kyn aminotransferase 1 (KAT1) are all up-regulated in many cancer types, whereas Kyn monooxygenase (KMO), kynureninase (KYNU), 2-amino-3-carboxymuconic acid-6-semialdehyde decarboxylase (ACMSD) and quinolinate phosphoribosyltransferase (QPRT) are up-regulated in a few, but down-regulated in many, cancers. This results in accumulation of the aryl hydrocarbon receptor (AhR) ligand kynurenic acid and in depriving the host of NAD+ by blocking its synthesis from quinolinic acid. The host loses more NAD+ by up-regulation of the NAD+-consuming poly (ADP-ribose) polymerases (PARPs) and the protein acetylaters SIRTs. The nicotinamide arising from PARP and SIRT activation can be recycled in tumours to NAD+ by the up-regulated key enzymes of the salvage pathway. Up-regulation of the Trp transporters SLC1A5 and SLC7A5 is associated mostly with that of TDO2 = FAMID &gt; KAT1 &gt; IDO2 &gt; IDO1. Tumours down-regulate enzymes of serotonin synthesis, thereby removing competition for Trp from the serotonin pathway. Strategies for combating tumoral immune escape could involve inhibition of Trp transport into tumours, inhibition of TDO and IDOs, inhibition of FAMID, inhibition of KAT and KYNU, inhibition of NMPRT and NMNAT, inhibition of the AhR, IL-4I1, PARPs and SIRTs, and by decreasing plasma free Trp availability to tumours by albumin infusion or antilipolytic agents and inhibition of glucocorticoid induction of TDO by glucocorticoid antagonism.
Protecting glomerulus: role of angiotensin-II type 2 receptor
Authors: Patel Sanket , Kulkarni Kalyani , Hussain Tahir 
Published: October 2022

Abstract
Podocyte injury due to either drug, toxin, infection, or metabolic abnormality is a great concern as it increases the risk of developing focal segmental glomerulosclerosis (FSGS) and proteinuric kidney diseases. The direct podocyte injury due to doxorubicin is associated with an increase in proinflammatory cytokines and induction of cathepsin L. The increased activity of cathepsin L in turn may degrade the glomerular slit diaphragm resulting in proteinuric kidney injury. The angiotensin-II type 2 receptor (AT2R) has earlier been reported to be associated with the preservation of slit diaphragm proteins and prevention of proteinuria. Recent in vivo findings by Zhang and colleagues further support the anti-proteinuric role of AT2R in preventing podocyte injury via down-regulating cytokines ccl2, and hence, cathepsin L, thereby, limiting the progression of FSGS.
Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction
Authors: Lunardon Guilherme , de Oliveira Silva Tábatha , Lino Caroline A. , Lu Yao Wei , Miranda Juliane B. , Asprino Paula F. , de Almeida Silva Amanda , Nepomuceno Gabrielle T. , Irigoyen Maria Cláudia Costa , Carneiro-Ramos Marcela S. , Takano Ana Paula C. , Martinho Herculano da Silva , Barreto-Chaves Maria Luiza M. , Wang Da-Zhi , Diniz Gabriela P. 
Published: October 2022

Abstract
Cardiovascular diseases are the main cause of death worldwide. Recent studies have revealed the influence of histone-modifying enzymes in cardiac remodeling and heart dysfunction. The Set7 methyltransferase regulates the expression of several genes through the methylation of histones and modulates the activity of non-histone proteins. However, the role of Set7 in cardiac remodeling and heart dysfunction remains unknown. To address this question, wild-type (WT) and Set7 knockout (KO) male mice were injected with isoproterenol or saline. WT mice injected with isoproterenol displayed a decrease in Set7 activity in the heart. In addition, WT and Set7 KO mice injected with isoproterenol exhibited cardiac hypertrophy. Interestingly, Set7 deletion exacerbated cardiac hypertrophy in response to isoproterenol but attenuated myocardial fibrosis. Echocardiograms revealed that WT mice injected with isoproterenol had lowered ejection fractions and fractional shortening, and increased E′-wave deceleration time and E/A ratio compared with their controls. Conversely, Set7 KO mice did not show alteration in these parameters in response to isoproterenol. However, prolonged exposure to isoproterenol induced cardiac dysfunction both in WT and Set7 KO mice. Both isoproterenol and Set7 deletion changed the transcriptional profile of the heart. Moreover, Set7 deletion increased the expression of Pgc1α and mitochondrial DNA content in the heart, and reduced the expression of cellular senescence and inflammation markers in response to isoproterenol. Taken together, our data suggest that Set7 deletion attenuates isoproterenol-induced myocardial fibrosis and delays heart dysfunction, suggesting that Set7 plays an important role in cardiac remodeling and dysfunction in response to stress.