bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mite allergen avoidance decreases allergic symptoms in children in Ishinomaki city of Japan after natural disasters
Authors: Oshikata Chiyako , Watanabe Maiko , Hashimoto Kazuhiro , Yamazaki Akiko , Kobayashi Naoki , Konuma Rumi , Ishida Masatsugu , Kobayashi Seiichi , Shimada Takashi , Kaneko Takeshi , Kamata Yoichi , Kuriyama Shinichi , Kure Shigeo , Yanai Masaru , Tsurikisawa Naomi 
Published: March 2022

Objective: We investigated the prevalence of asthma, rhinitis, and atopic dermatitis in children, evaluated the mite allergen levels in their bedding after the Great East Japan Earthquake, and assessed changes in allergic symptoms in children and their families after allergen avoidance practices.
Methods: We performed a survey for the International Study of Asthma and Allergies in Childhood (ISAAC) comprising 1109 children, aged 7–8 years, living in Ishinomaki, Japan. We collected responses from 464 children, and in 2016, measured the level of Dermatophagoides group 1 (Der 1) in the bedding of 202 of these children. The intervention group of children attended at least one allergen avoidance seminar. The levels of Der 1 in their bedding were measured, along with changes in allergic symptoms, in 17 children in 2017 and 14 children in 2018. The nonintervention group comprised children who did not attend an allergen avoidance seminar at any time.
Results: Of the 464 children who participated in the ISAAC, 50 (10.8%) reported having asthma, 179 (38.8%) allergic rhinitis, and 126 (27.3%) atopic dermatitis. The average level of Der 1 measured in the bedding of the 202 children in 2016 was 295.8 ng/m2. The levels of Der 1 in the intervention group—but not in the nonintervention group—significantly decreased in 2017 and 2018. The symptoms of asthma, allergic rhinitis, and atopic dermatitis in the children of intervention group and their families decreased after allergen avoidance practices.
Conclusions: Allergen avoidance practices relieved allergic symptoms in school children after the Great East Japan Earthquake.
Persistence of airborne tree pollen from the Cupressaceae family during the last decade in the city of Bahia Blanca
Authors: Ramon German D. , Felix Miguel , Barrionuevo Laura B. , Maria Benedetti Graciela , Duval Valeria Soledad , Vanegas Emanuel , Cherrez-Ojeda Ivan 
Published: March 2022

Airborne pollen is a major contributor to allergic respiratory diseases. However, the literature on patterns and seasonality of specific pollen types mainly comes from northern hemisphere and developed regions, limiting our ability to extrapolate these findings to other geographical locations. With this research letter, our aim is to contribute to the current knowledge of aerobiology by analyzing the decade-long patterns of airborne tree pollen in the city of Bahia Blanca, Argentina. In general, we found late winter to early spring as the period with the highest Cupressaceae pollen counts. In 2020, the average pollen count during July through September was 78.81 (SD 79.70), the highest recorded during the last 10 years. These months had varying pollen concentrations from moderate (15–89 grains/m3 of air) to high (90–1499 grains/m3 of air). Regardless of such variation, August had consistently been the month with the highest peak concentrations from 2010 to 2020 (61.2, SD 57.3), followed by September (27.1, SD 20.3). We did not find any month with very high (˃1500 grains/m3 of air) peak concentration. Further studies need to be done to expand our knowledge on aerobiology to characterize specific pollen sub-types and determine the exact allergenic potential of airborne pollen in different regions.
VİLAYET AKSARAY ile KAZA AKSARAY’IN SİYASİ ve İKTİSADİ AÇIDAN BİR DEĞERLENDİRMESİ (1921-1989)
Authors: CAN Ayşegül 
Published: March 2022

Orta Anadolu'da yer alan Aksaray, tarihi açıdan oldukça önemli yolların birleştiği noktada bulunmaktadır. Bu sebeple tarihi süreçte pek çok devletin egemenliği altında kalmış ve şehrin idari taksimatında değişiklikler meydana gelmiştir.
Bu çalışmada Aksaray’ın 1921-1989 yılları arasındaki zaman diliminde idari taksimatının vilayet ve kaza olarak değişmesinin, siyasi ve iktisadi hayatında meydana getirdiği gelişmeler irdelenmiştir. Böylece Cumhuriyet’in ilk yıllarındaki Aksaray’ın vilayet olarak siyasi ve iktisadi portresini ortaya koymak amaçlanmıştır. Ayrıca 1933’te başlayan ve 1989’a kadar olan zaman diliminde kaza olan Aksaray’da meydana gelen gelişmelerin Aksaray halkında ne gibi etkiler yarattığı sorusuna cevap aranmıştır. Bulunan cevaplar ışığında Aksaray idari tarihinin, şehrin ve halkın üzerinde oluşturduğu siyasi ve iktisadi gelişmeler analiz edilmiştir. Bir anlamda Cumhuriyet’in ilk dönemlerinden itibaren vilayet olan Aksaray’ın 1989’da tekrar vilayet olmasıyla birlikte nasıl bir gelişim gösterdiğini ortaya koyacak çalışmada, başta Başkanlık Cumhuriyet Arşivi, Resmî Gazete, TBMM Zabıt Cerideleri ve telif eserler olmak üzere birçok kaynaktan istifade edilmiştir.
О программе перехода на низкоуглеродное топливо в энергетике Республики Казахстан
Authors: Калыбай А.А. 
Published: March 2022

В работе изложены технология и состав оборудования технологической линии низкотемпературной (не выше 75 оС) гидроконверсии энергетического угля на высококалорийное (теплота сгорания 45М Дж/кг, экологически чистое (очищенное от золы) жидкое гидрогенизированное угольное топливо (ГУТ) с низким содержанием углерода (менее масс. 45%), способы сжигания ГУТ (топливная аппаратура и инновационная горелка), средства улавливания и утилизации парниковых газов (плазмохимический реактор) и производства наноматериалов (углерод, кремний, алюминий, титан и др.) Цель статьи – указать пути сохранения угольной отрасли, вырабатывая из энергетического угля ГУТ с низкой себестоимостью, наноматериалов высокой добавленной стоимости и осуществляя технически эффективный экологический чистый переход на низкоуглеродную энергетику с нулевым выбросом парниковых газов (ПГ).
Shaping open, distance and e-learning in post school education and training: A call for a revised agenda
Authors: Aluko Ruth , Krull Greig , Mhlanga Ephraim 
Published: March 2022

The impact of the COVID-19 pandemic has brought the attention of distance education issues to the fore in a way not seen before. All forms of educational provision and sectors were affected by the pandemic. The aim of this conceptual leading article is to highlight three pertinent issues that need to be taken into account in Open, Distance and e-Learning (ODeL) to ensure the relevance of the Post School Education and Training (PSET) sector in the Fourth Industrial Revolution (4IR) and beyond. Based on a review of the literature, the article highlights three pillars of successful use of technology to enhance quality in PSET, especially in the wake of the worldwide transition to remote teaching and learning. The revised agenda comprises the questioning of previously held beliefs about learning and teaching; the responsiveness of curricula and ensuring the quality of ODeL offerings. It argues that unless traditional beliefs about teaching and learning are questioned and curricula are streamlined to align with the demands of the knowledge society, the value of PSET may be trivialised in a context that is so rapidly changing. It also argues that sound quality assurance mechanisms should be put in place to ensure sufficient depth in student learning experiences, rigour in assessment processes and confidence in graduates by employers and society at large. Using the theory of Connectivism as a lens, the authors provide a framework with some recommendations for sound ODeL teaching and learning practices that are relevant for the demands of the 4IR and beyond. The framework focuses on five pillars, which are foregrounding a student-centred approach; embracing appropriate technologies to support teaching and learning; strengthening the capacity to support success; ensuring appropriate assessment processes and regular curriculum revision and renewal.
Leveraging academic-industry partnerships for inclusive virtual learning
Authors: Zvavahera Promise , Garwe Evelyn Chiyevo , Pasipanodya Sheppard , Chigora Farai , Katsande Chipo 
Published: March 2022

The COVID-19 pandemic has caused serious disruptions to higher education institutions across the globe, prompting even the ill-prepared ones to embrace virtual teaching and learning approaches. Academic-industry partnerships remain an underutilised and under-researched mutually beneficial way of strengthening organisational performance. This study used the case of Zimbabwe to fill the gap in the literature by exploring the types and extent of cooperation between academic institutions and industry towards inclusive virtual learning in public and private universities during the COVID-19 pandemic. The study used electronic questionnaires and virtual interviews to collect data from a sample of 100 university staff and executives in industry. The findings revealed major challenges concerning infrastructure, facilities, high cost of data and intermittent power cuts. At present, particularly in public universities, academic-industry synergies were focused on internet and data provision. However, no support was made available for infrastructure and related facilities. The study recommended the need for strong academic-industry partnerships towards funding infrastructure and facilities to enhance virtual teaching and learning.
Participatory parity through teaching with Telegram
Authors: Swartz Bronwyn Claudia , Valentine Lucrecia Zinobia , Jaftha Desiree Virginia 
Published: March 2022

The COVID19 pandemic thrust emergency remote teaching (ERT) into the global spotlight and thereby undeniably changed aspects of the higher education (HE) landscape. For a developing country such as South Africa (SA), the use of the mobile instant messaging (MIM) application (app) called Telegram represents a practicable solution to overcome historical socio-economic challenges faced by certain demographic groups of limited or restricted access to devices and data. Against this backdrop, a Telegram teaching intervention was developed by two lecturers in the Engineering Faculty at a University of Technology (UoT) in SA to deliver curriculum content and engage with students in a low-tech, low-cost/low-data usage manner, and consequently to widen access to education, promote inclusivity and thereby facilitate student access, retention and success. This study explored student perceptions of the MIM app being used as a primary vehicle to deliver succinct instructional materials and facilitate class activities to offset the lack of faceto-face classes in a multimodal and flexible curriculum delivery approach. Following the completion of the Telegram teaching intervention, a mixed method approach was used that included two online surveys measuring different aspects of the same project (n=34 and n=32) and a focus group interview (n=6). Three research lenses suggested by Fraser (2008) were used to evaluate student perceptions of the usefulness and (dis)advantages of Telegram. These lenses were: (1) redistribution (of resources), (2) recognition (related to social status) and (3) representation (who can act/say/ challenge in an academic environment). Ethical clearance was obtained from Cape Peninsula University of Technology’s Ethics committee. Initial results indicate that using the Telegram app for teaching and learning was successful. Significantly, the app allows for the emergence of a socially just online classroom environment and an inclusive and enabling learning experience for the students during a very disruptive and fearful time in the world’s history.
Investigating TVET college educators’ experiences while transitioning from the traditional classroom to the virtual classroom during the COVID-19 pandemic
Authors: Aina Adebunmi Yetunde , Ogegbo Ayodele Abosede 
Published: March 2022

The growing utilisation of digital technologies in today’s complex and fast-changing world has taken the reality of education beyond the physical classroom. However, the COVID-19 pandemic has forced many educational institutions to make hasty and unprecedented decisions as they switched to the virtual classroom. This study explores teachers’ experiences in transitioning from traditional teaching to virtual teaching during and after the COVID-19 college closure. A sample of seven Technical and Vocational Education and Training (TVET) educators was conveniently selected from colleges in an urban area in South Africa using a case study research design. Data were collected through semi-structured interviews and analysed using thematic analysis. In this regard, all ethical considerations were adhered to during this study. Three of the educators demonstrated a positive cognitive, affective and behavioural attitude towards transitioning to virtual learning. Six of the educators used WhatsApp and online platforms integrated into their college’s website to communicate during virtual teaching. However, challenges such as lack of support on the integration of technology into their practice, access to connectivity, provision of little or no training on pedagogical practices, unconducive home environment, students’ attitudes in the online space, lack of infrastructure and poor policy guidelines and framework for implementing virtual learning pose a threat to educators’ desires to change and support a transition to virtual learning permanently. Therefore, it is recommended that TVET education providers and managers provide adequate support and training for educators to foster pedagogical practices aimed at enhancing students’ virtual learning.
Currículo e práticas na educação superior no contexto da pandemia da COVID-19
Authors: Nez Egeslaine de , Fernandes Cleoni Maria Barboza , Woicolesco Vanessa Gabrielle 
Published: March 2022

O contágio pelo vírus Sars-CoV-2 trouxe consequências para todas as esferas da vida social, e a Educação Superior também precisou responder a emergência sanitária. A velocidade de resposta das Instituições de Educação Superior para a manutenção das atividades acadêmicas neste cenário esteve relacionada às capacidades técnicas, tecnológicas e o domínio do modelo de Educação à Distância e/ou Online já instalado. A discussão sobre a acessibilidade digital e a conectividade também permearam a construção dessas respostas. Esse estudo tem como objetivo analisar as práticas pedagógicas universitárias e a necessidade de reinvenção curricular impostas pela crise mundial da pandemia da COVID-19. A abordagem da investigação é quanti-qualitativa. Foi realizada uma pesquisa bibliográfica e aplicado um questionário semiestruturado online. A amostra é composta por 106 docentes que atuam em Instituições de Educação Superior públicas e privadas brasileiras. Os achados da pesquisa evidenciam que o contexto pandêmico exigiu um modelo pedagógico emergente, denominado de ensino remoto emergencial. Constatou-se que houve o esforço dos professores de se qualificarem para a utilização de tecnologias digitais na mediação do processo de ensino e aprendizagem, readequação curricular e das práticas pedagógicas, possibilitando aos estudantes novas experiências de aprendizagem.
KUALITAS FISIK WAFER RANSUM KOMPLIT MELALUI PENAMBAHAN KULIT BUAH KAKAO FERMENTASI YANG DISIMPAN DENGAN JENIS KEMASAN DAN WAKTU YANG BERBEDA
Authors: Nasution Muhammad Affan Amin , Harahap Anwar Efendi , Erwan Edi 
Published: March 2022

The use of packaging wafer is one way to protect feed from various factors that can cause a decrease in the quality of the stored feed. Storage aims to maintain and preserve stored commodities by avoiding, eliminating various factors that can reduce the quality and quantity of the commodity. This study uses a completely randomized factorial design (5 x 3) with 3 replications. Factor A is the type of packaging consisting of A0 = without packaging, A1 = packaging bags of rice, A2 = packaging bags of plastic, A3 = packaging bags of papers, A4 = packaging bags of sacks. Factor B is the storage time B0 = 0 days B1 = 14 days B2 = 28 days. The parameters were the texture, color, aroma, water absorption, density. The results showed that there was an interaction between different types of packaging and storage duration of the texture, color, aroma and density of the complete wafer skin of fermented cocoa pods with different types of packaging and storage time. The type of rice sack packaging with 14 days storage time produces the best physical wafer quality compared to other treatment combinations seen from the texture of water absorption and density
Intraoperative Anaphylaxis to the Bovine Flowable Gelatin Matrix
Authors: Coury Josephine R. , Skaggs Kira F. , Marciano Gerard F. , Pinyavat Teeda , Naseef Mervat , Roye Benjamin D. , Vitale Michael G. 
Published: March 2022

Case:
We present 2 cases of life-threatening intraoperative anaphylaxis to the bovine flowable gelatin matrix during pediatric spinal deformity surgery for kyphoscoliosis. Both patients had no known bovine or gelatin allergies. Anaphylaxis occurred shortly after pressurized injection into the first cannulated pedicle tract and was successfully treated with epinephrine, diphenhydramine, and methylprednisolone infusion. The allergic reaction was confirmed with tryptase levels and serum-specific immunoglobulin E for beef, pork, bovine collagen, and porcine collagen.

Conclusion:
In patients with beef, pork, or gelatin intolerance, a significant atopic history or childhood vaccine reaction, preoperative allergy consultation, and testing should be performed to prevent this life-threatening complication.
Health Inequality of Left-behind Children in Rural Regions: Evidence from China
Authors: Fan Qiuyan , Guan Peizhong , Nicholas Stephen , Maitland Elizabeth , Wang Jian 
Published: March 2022

Abstract
Background: In China, large-scale population movement and increased childcare costs have brought about a "care crisis" for rural children left-behind when their parents migrate to cities. The unprecedented scale of internal population migration poses multiple challenges to the health of left-behind children in rural areas. Rural left-behind children are currently experiencing insufficient caregiving capacity of intergenerational guardians; the impact of serious parental absences; inadequate nutritional and dietary support and healthy behaviours; limited health service utilization; and abnormally high levels of poor mental health.Purpose: Using 2016 China Family Panel Studies’ micro-data two issues were explored: What is the current status of health inequality in rural left-behind children, including the degree of health inequality and differences in health inequalities of left-behind children in different regions and different age groups; and, second, what are the socioeconomic factors (income deprivation, access to medical services, migrating parents) and inter-generational care arrangements that impacted the health inequality of left-behind children? Method: The health indicators of left-behind children were measured by the concentration index (CI), and the contribution of each socio-economic variable to health inequality was decomposed through the RIF-I-OLS model.Results: The health inequality of left-behind children in rural areas was pro-rich. Left-behind children under 5 years of age had the highest health inequality in all regions; the availability of medical services had a significant negative impact on the health inequality of left-behind children in rural areas, especially in the western provinces; income deprivation had a significant positive effect on the health inequality of left-behind children in rural areas, most notably in the eastern provinces; migrant parents had a negative, and intergenerational caregivers a positive, impact on the health inequality of left-behind children; and left-behind children in the western provinces suffered the largest negative impact on their health. Finally, left-behind children experienced relative health inequality due to their sex, education level and health endowments. Policy recommendations are advanced to address issues of health inequalities in rural left-behind children.
A Potential Prognosis and Immune Biomarker in Cancer: DICER1
Authors: Bao Lewen , You Xia , Ge Minghui , He Qianru , Sun Tingting , Qi Chuang , Li Lifeng , Wang Yongpeng 
Published: March 2022

Abstract
Background: DICER1 plays a significantly important role in short dsRNA-mediated post-transcriptional gene silencing that is deeply embedded in the network of cancer genes. Aberrant expression and mutation of DICER1 have been studied and reported to be closely associated with tumorigenesis and development, while lower levels of DICER1 mRNA or protein are associated with poorer prognosis in some cancers. However, there is little research about the effect and mechanism of mutated DICER1. Materials and Methods: In our study, DICER1 mutation in the TCGA database from the top 10 cancers were analyzed to explore the effect of DICER1 mutants in cancer prognosis and the possible potential mechanisms. Results: We found that DICER1 mutation was closely related to better clinical outcomes in pan-cancer and uterine corpus endometrial carcinoma (UCEC) treatment, which meant that DICER1 could be served as a prognosis factor for pan-cancer, especially UCEC. And mechanism research indicated that DICER1-mut facilitated antitumor immunity, which could be the potential mechanism for DICER1-mut prognosis value. Moreover, tumor microenvironment (TME) features and higher TMB of DICER1-mut manifested that DICER1 may be a potential biomarker of immunotherapy, which needed more clinical and basic research to validate.Conclusions: In summary, our finding suggested that DICER1 may be a potential prognostic biomarker and was associated with TME in UCEC. In addition, it might be a marker of immunotherapy.
TP53 signature score predicts prognosis and immune response in triple-negative breast cancer
Authors: Onishi Mai , Yamaguchi Shigeo , Wen Xuan , Han Min , Kido Hidenori , Aruga Tomoyuki , Horiguchi Shin-ichiro , Kato Shunsuke 
Published: March 2022

Abstract
Purpose
Triple-negative breast cancer (TNBC) is considered a heterogeneous population and achieving a pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) is an only prognostic factor. Previously, the TP53 signature (TP53sig)-score, an expression profile of 33 genes, is reportedly predictive of the prognosis of all types of early-stage breast cancer. Herein, we analyzed whether the TP53sig-score can be subclassified in detail with only a TNBC cohort and investigated the molecular biological characteristics of the higher TP53sig-score.
Methods
Publicly available data from TCGA(RNA-sequence) and METABRIC (microarray) and real clinical specimens’ s expression data (NanoString Technologies) were used to explore the prognosis and molecular features of TNBC.
Results
The high TP53sig-score group in the present study and the cohort in METABRIC tended to have a worse prognosis than the low TP53sig-score group (p=0.583 and 0.196, respectively). In both the pCR and non-pCR groups, the high TP53sig-score patients tended to have a poor prognosis (p=0.0739). Moreover, when the NAC response and TP53sig-score were combined, the five-year breast cancer-free rate among the four groups differed significantly (p=0.043). In addition, high TP53sig-score was related to gene ontology terms, such as “cell differentiation” and “innate immune response. Notably, this group had the potential to respond favorably to immunotherapy according to the tumor immune dysfunction and exclusion model.
Conclusion
Combining the response to NAC and the TP53sig-score in triple-negative breast cancer was able to predict an unfavorable prognosis. Further, patients with a high TP53sig-score showed a favorable feature associated with immunotherapy