bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finite-Time Adaptive Fuzzy Control of Fractional-Order Nonlinear Systems With Multiple Objective Constraints
Authors: Ding Lusong , Sun Weiwei 
Published: September 2022

Abstract
This paper presents an adaptive fuzzy finite-time control strategy for uncertain nonstrict-feedback fractional-order nonlinear systems with multiple-objective constraints. To stabilize the uncertain nonlinear fractional-order systems, the fuzzy logic systems are employed to identify the unknown nonlinear functions, the dynamic surface control is used to avoid the computational complexity of the backstepping design procedure, and the effect caused by the algebraic loop problem can be solved via establishing fractional-order adaptive laws. By introducing a new barrier function, the system output is always limited to the predefined time-varying acceptable range while effectively solving the multi-objective constraint problem. By utilizing fractional-order finite-time stability theory, a finite-time control scheme is constructed to drive the system output to the reference signal in finite time, which ensures better tracking performance. Two examples are given to illustrate the availability and superiority of the presented control scheme.
Influence factors of bamboo intake in captive giant pandas (Ailuropoda melanoleuca)
Authors: Wei Ming , Zhu Yan , Liu Weiping , Li Desheng , Wei Rongping , Deng Linhua , Wu Kai , Song Shixian , Li Ti , Zeng Wen , He Yongguo , Huang Shan , Wang Chengdong 
Published: September 2022

Abstract
Bamboo is the main food source of the giant panda. To increase bamboo intake in captive giant pandas, we studied factors affecting the bamboo intake. Fourteen healthy captive giant pandas in Dujiangyan Base of China Conservation and Research Center for The Giant Panda (" Dujiangyan Base "for short) were selected as research objects. Bamboo feeding experiment was conducted to study the effects of seasons, bamboo age, slope orientation and felling-feeding time on bamboo intake of the giant panda. We found that the type of bamboo that captive giant pandas feed on was rich in spring and summer, but relatively simple in winter. With the increase of bamboo age, the intake of bamboo leaves decreased, while bamboo culms increased. The feed intake of 1-year-old bamboo leaves and 5-year bamboo culms reached the highest respectively. The slope orientation of bamboo growth also affected the panda's bamboo intake. Moreover, the bamboo intake reached the highest when the felling-feeding time was less than 24h. In short, we confirmed that seasons, bamboo age, slope orientations and felling-feeding time were factors affecting bamboo intake for captive giant pandas. This study was expected to provide scientific guidance improving the feeding behavior management of captive giant pandas.
High Plasma EBV-DNA Load and Positive EBER Status Associated with Viral Recurrence and Persistent Infection in Early Treatment of Lymphoma
Authors: Zeng Meichun , Jia Qingjun , Chen Jingjing , Xu Liming , Xie Li , Cheng Qinglin , Li Qingchun , Xiao Ming , Fang Zijian 
Published: September 2022

Abstract
The relationship between plasma EBV-DNA load (PEDL) and Epstein-Barr virus (EBV)-encoded small RNA (EBER) during early treatment of lymphoma remains unclear. We explored discrepancies in PEDL and variables associated with EBER, and evaluated the consistency between EBER and qualitative analysis of PEDL (qPEDL). Serial measurements of PEDL were performed to determine the dynamic changes of PEDL in early treatment of lymphoma. As a result, the median PEDL of NHL-NKT was higher than that of NHL-B, the median PEDL of ENKTCL was higher than that of DLBCL, and the median PEDL of EBER positive was higher than that of EBER negative. Age, Ki-67 ≧ 80%, Bcl-2 ≧ 80%, p53 and qPEDL were related to EBER. The PEDL could distinguish NHL-B, DLBCL, NHL-NKT and ENKTCL from other lymphoma subtypes. EBER-positive patients spent more time with viral “turn negative (TN)” and “continuous positive (CP)”, and less time with viral “continuous negative (CN)”. The median PEDL of CP was higher than that of TN. In conclusion, although EBER affects the levels of PEDL in general, it has poor concordance with qPEDL. Our results show, for the first time, that high PEDL and positive EBER present a strong association with viral recurrence and persistent infection in the early treatment of lymphoma.
Differential dysregulation of CREB and synaptic genes in transgenic Drosophila melanogaster expressing shaggy (GSK3), TauWT, or Amyloid-beta
Authors: Ataellahi Fatemeh , Masoudi Raheleh , Haddadi Mohammad 
Published: September 2022

Abstract
Background: Tau, Amyloid-beta (Aβ42), and Glycogen synthase kinase 3 (GSK3) contribute to synaptic dysfunction observed in Alzheimer's disease (AD), the most common form of dementia. In the current study, the effect of pan-neuronal expression of TauWT, Aβ42, or shaggy (orthologue of GSK3) in Drosophila melanogaster was assessed on the locomotor function, ethanol sensitivity, synaptic genes and CREB expression. The effect of TauWT and Aβ42 on the expression of shaggy was also determined.Methods and results: Gene expression analysis performed using quantitative real-time RT-PCR method. While syt1, SNAP25 and CREB (upstream transcription factor of syt1 and SNAP25) were upregulated in flies expressing TauWT or Aβ42, a prominent decline was observed in those genes in shaggy expressing flies. While all transgenic flies showed climbing disability and higher sensitivity to ethanol, abnormality in these features was significantly more prominent in transgenic flies expressing shaggy compared to TauWT or Aβ42. Despite a significant upregulation of shaggy transcription in TauWT expressing flies, Aβ42 transgenic flies witnessed no significant changes.Conclusions: TauWT, Aβ42, and shaggy may affect synaptic plasticity through dysregulation of synaptic genes and CREB, independently. However shaggy has more detrimental effect on synaptic genes expression, locomotor ability and sensitivity to ethanol. It is important when it comes to drug discovery. It appears that CREB is a direct effector of changes in synaptic genes expression due to the same pattern of their alteration and it is likely to be a part of compensatory mechanisms independent of the GSK3/CREB pathway in TauWT or Aβ42 expressing flies.
Influence of Class A40 Type Autonomous Truck on Rutting and Fatigue Cracking
Authors: Fahad Mohammad , Nagy Richard 
Published: September 2022

Abstract
Effect of autonomous trucks’ different lateral wander modes have been analysed in this research using a dload subroutine. Two lateral wander modes, a zero-wander mode in which a truck is programmed to follow a predetermined wheel path without any lateral movement and a uniform wander mode, where the truck uniformly distributes itself along the lateral width of the lane, are used. European class A40 truck has been modelled in ABAQUS. The effect of all the axles with varying loading and tire pressures has been studied while observing the microstrains under the asphalt layer and on the top of subgrade layer at speeds of 90 Km/h. Results show that fatigue life of pavement increases by 1.45 times if a uniform wander mode is used, which corresponds to a decrease in fatigue life of 14 months if a zero-wander mode is used. In case of rutting progression, 40% acceleration of rutting happens under a zero-wander mode. In case of uniform wander mode, rut depth decreases by 1.25 times against the zero wander mode.
Neuroimaging and Cognitive Testing in Healthy Aging Adults using a Portable Low-Field MRI Scanner and Web-Based Assessment
Authors: Deoni Sean CL , Burton Phoebe , Beauchemin Jennifer , Cano-Lorente Rosa , Both Matthew D. , Johnson Megan , Ryan Lee , Huentelman Matthew J. 
Published: September 2022

AbstractConsumer wearables and health monitors, internet-based health and cognitive assessments, and at-home biosample (e.g., saliva and capillary blood) collection kits are increasingly used by public health researchers to recruit and follow large study populations without requiring intensive in-person study visits. In addition to reducing participant time and travel burden, remote and virtual data collection allows individuals who live long distances from a hospital or university research center, have limited time or mobility, or who lack access to transportation to participate. Unfortunately, studies that include magnetic resonance neuroimaging can be particularly burdensome given the infrastructure requirements of 1.5, 3, and 7 Tesla scanners. As a result, they often omit socially, economically, and educationally disadvantaged individuals. Portable lower magnetic field strength systems offer the potential to perform neuroimaging at a participant’s home and convenience. In this work, we present the first report of associations between brain morphometry and cognitive performance assessed using a portable low-field MRI “scan van” and an established online assessment (MindCrowd) of paired-associate learning (PAL). In a sample of 67 individuals between 18–93 years of age who were imaged at their home or convenient nearby location, we show expected trends in brain volumes with age and detail associations between learning and memory-related brain region volumes and PAL performance. Results demonstrate the ability to collect neuroimaging and cognitive data outside of traditional imaging research settings with important implications for engaging traditionally underrepresented communities in neuroimaging research.
The Timing of Intravenous Antibiotic Regimens and Clinical Outcomes of Mycobacterium abscessus complex Lung Diseases: a retrospective multicenter cohort study
Authors: Pang Ai-Hsin , Lin Shu-Wen , Yang Jeng-How , Wang Ping-Huai , Pan Sheng-Wei , Wei Yu-Feng , Chen Chung-Yu , Lee Ho-Shen , Wu Ting-Shu , Chang Chin-Hao , Shu Chin-Chung 
Published: September 2022

Abstract
BackgroundThe treatment of Mycobacterium abscessus complex lung diseases (MABC-LD) requires a combination of multiple antibiotics, including at least 1 initial intravenous (IV) agent. However, the importance of early IV antibiotics use, as recommended in the guidelines for MABC-LD treatment, remains unknown. MethodsA retrospective observational study was conducted in 6 hospitals in Taiwan. Patients who were diagnosed with and received treatments for MABC-LD from January 2007 to April 2021 were included, but patients with treatment durations of shorter than 14 days were excluded. Treatment outcome was defined as modified microbiological cure of MABC-LD. ResultsThirty-four of the 89 enrolled patients (38.2%) received IV antibiotics in the treatment course. The median time to IV initiation was 1 day (IQR: 1–49), and 24 (70.6%) of them received IV agents within 4 weeks, defined as early use. Forty-two (47.2%) patients achieved modified microbiological cure. In the multivariable logistic analysis, early IV antibiotics use was an independent factor associated with modified microbiological cure (adjusted odds ratio [aOR] 8.58, 95% CI: 2.31–31.86), whereas high radiological score (aOR 0.83, 95% CI: 0.70–0.98) and long treatment duration (aOR 0.998, 95% CI: 0.996–0.999) demonstrated negative association. ConclusionsIn the present study, early use of IV effective antibiotic was prescribed in a low percentage (27%) for MABC-LD. By contrast, early IV antibiotics use was correlated with higher microbiological cure than were late or non-use. Greater adherence to the guideline may improve the clinical outcome in treating MABC-LD. Future larger and prospective studies are needed to validate the association.
Multidisciplinary approach to severe mitral valve regurgitation in a patient refusing blood transfusion – perks of minimal invasive mitral valve surgery
Authors: Miazza Jules , Koechlin Luca , Heppel David , Doebele Thomas , Eckstein Friedrich S. 
Published: September 2022

Abstract
Background: Patients refusing blood product transfusion represent a particular cardiac surgery population in which bleedings and hemodilution should be maximally reduced. Case presentation: We present the case of a 60 years old, Jehovah witness patient refusing whole blood transfusion and primary blood components, who required surgery for severe and symptomatic mitral valve regurgitation. To avoid critical bleeding, we performed careful preoperative assessment, documenting coagulation anamnesis and accepted drugs using a standardized form. In case of a bleeding, the anesthesia team was prepared for a proactive and goal-oriented correction of the coagulation using artificial products. Should it be needed, measures to increase anemia tolerance would also have taken place, for example narcosis deepening. The operation was performed in a minimally invasive fashion using a right anterior thoracotomy and video-assistance. The cardiopulmonary bypass was conducted using 3/8 inches venous lines and small-sized oxygenator in order to reduce priming volume. Using a ring anuloplasty and plication of the anterior mitral valve leaflet, mitral valve repair was achieved with no sign of regurgitation or stenosis. The postoperative course was uneventful and the patient was discharged on postoperative day 8 with a hemoglobin level of 109g/l. Conclusion: Patient refusing blood transfusion represent a particular subset of the cardiac surgery population. In order to offer standard of care in such situations, a multidisciplinary, patient-centered concept based on close collaboration between cardiac surgeons, anesthetists and perfusionist is of utmost importance. In this case we, once again, demonstrated the safety and feasibility of minimally invasive mitral valve repair and its usefulness in patients where reduced hemodilution and fast recovery are needed.
L2 norm-constrained adaptive edge preservation filter inversion of exact Zoeppritz equation
Authors: Xu Zihe , Lu Yongxu , Peng Suping , Cui Xiaoqin , Liao Jin , Shi Haolei 
Published: September 2022

Abstract
Since traditional pre-stack inversion via amplitude variation with offset (AVO) uses an approximate formula, it is insufficiently accurate at large angles. To overcome this shortcoming, we used the exact Zoeppritz equation for nonlinear AVO inversion. A second-order difference matrix is ​​added to suppress the disturbance of the inversion in the case of noise.We used an adaptive edge preservation (Ad-EPS) filter to process the iterative model. An Ad-EPS filter can find the optimal window size for each filtered sample so that the formation boundary is sharper and more accurate in the inversion. For nonlinear optimization problems, we used the Levenberg–Marquardt method. The LM method adds a damping factor to the iterative equation to reduce the ill-posedness of the inversion and can add a second-order-difference L2-norm-regularization term directly to the algorithm to make the inversion data closer to the model data. The LM method combines the exact Zoeppritz equation, L2 regularization constraints, and Ad-EPS filter into a nonlinear AVO inversion method called EZL2AEPS. The EZL2AEPS method is more accurate than the generally accurate Zoeppritz pre-stack inversion (EZPI) with respect to details such as formation boundaries and overall disturbances. The EZL2AEPS method can also suppress noise to a certain extent, reduce the effect of noise disturbance on the inversion, and produce blocky inversion results. Actual data show that the EZL2AEPS method achieves better inversion results and is a very advantageous AVO inversion method.
The environmental footprint of in silico-designed vegan, lacto-ovo-vegetarian and omnivorous diets complying with Mediterranean diet standards and essential amino-acid requirements
Authors: Tessari Paolo , Mosca Giuliano , Bittante Giovanni , Lante Anna 
Published: September 2022

Abstract
Background: The relationships between environmental variables, diet-type, and nutritional parameters are incompletely known.Objective: To estimate the environmental footprint and selected nutritional parameters of in silico-designed vegan (VEG), lacto-ovo-vegetarian (LOV) and omnivorous (OMN) weekly menus (n=7 for each type) complying with Mediterranean-Diet (MD) standards and satisfying Essential-Amino- Acids (EAA) requirements.Methods: Land-Use (LU), Water-Footprint (WF), Green-House-Gas-Emission (GHGE), sodium, saturated-fat, calorie, protein contents, and food weight, were calculated. A global EAA-based Nutritional and Environmental Score (EAA-NES) was developed.Key findings: Average LU, WF, GHGE, calories, protein and food weight, and EAA-NES scores, were similar among menu-types. In LOV menus, sodium and saturated fat were greater (by ≈140%, p<0.006, and by ≈60%, p<0.006), than in VEG or in VEG and OMN menus, respectively. However, the LU, GHGE and WF allocation of VEG menus fell predominantly into the first two quartiles (with lower environmental impact), whereas that of LOV and OMN menus was more scattered. No difference was found in the EAA-NES distribution among menu-types, by combining the two lower or the two higher quartiles.Conclusions: In silico-designed VEG diets might not exhibit a lower environmental impact, nor a better EAA-NES score, than LOV or OMN diets at safe EAAs requirements.
Occupational Happiness of Civilian Nurses in China: a cross- sectional study
Authors: Meng Ying , Luo Xue , Sun Peng , Luo Yu , Wang Zonghua , Wang Lihua , Ge Yuhong , Lin Li 
Published: September 2022

Abstract
Background: Civilian nurses have gradually become the main body of military nurses. Their professional well-being is of great significance to the quality of clinical nursing work and the improvement of medical service quality in military hospitals.Methods: This descriptive study was conducted with 319 civilian nurses working in 15 military hospitals in China. Based on the demographic questionnaire and the occupational happiness questionnaire of civilian nurses in military hospitals, the data were analysed by t test, analysis of variance and Pearson correlation analysis.Results: The occupational happiness score (3.83 ± 0.56, upper limit score: 5) was at the upper middle level. There were 233 nurses aged 31-40 (73%) and 258 married nurses (80.9%). A total of 285 nurses had bachelor's degrees (89.3%),166 nurses had the title of chief nurse (52.0%), the working years of 246 nurses were more than 10 years (77.1%), and 207 nurses (64.9%) had a monthly salary of more than 10000 yuan (RMB). There were significant differences in occupational well-being by gender (t = -2.668, p = 0.008), age (F = 5.085, p = 0.007) and the type of city where the hospital was located (F = 15.959, p < 0.0001). The happiness score of females (3.94 ± 0.60) was higher than that of males (3.47 ± 0.54). Nurses who were over 41 years old had the highest occupational happiness. Compared with nurses younger than 30 years old, the p value was 0.004. The occupational happiness of nurses in hospitals in a "prefecture-level city" (p < 0.0001) and a "sub-provincial city" (p < 0.0001) was significantly higher than that of nurses in hospitals in a "municipality directly under the central government". Correlation analysis showed that the higher the nurses’ satisfaction with professional identity, work output, work environment, salary, and interpersonal relationships, the higher their occupational happiness.Conclusion: Nurses who are female and older than 41 years old and whose hospitals are in "prefecture-level city" and "sub-provincial city" have higher occupational happiness. Professional identity, work output, work environment, salary, and interpersonal relationships also affect occupational happiness. The occupational happiness of civilian nurses in Chinese military hospitals is above the medium level, which is an important guarantee of the quality of clinical nursing work and the improvement of medical service quality.
Role of triglyceride as a predictor in autoimmune hepatitis with cirrhosis
Authors: Wang Peng , Wang Yuqi , Liu Hui , Han Xiaoxu , Yi Yunyun , Wang Xin , Li Xin 
Published: September 2022

Abstract

BackgroundMetabolism-related indicators have been suggested as possible prognostic indicators of liver disease in recent relevant studies, but their value in autoimmune hepatitis (AIH) cirrhosis is unclear. This study evaluated the role of lipid levels on the prognosis of AIH-related cirrhosis.MethodsWe retrospectively included 345 patients with AIH initially diagnosed in Beijing Ditan Hospital from 2010-2019, and finally screened 196 patients who met the criteria. We used logistic regression to screen factors associated with cirrhosis. Kaplan-Meier (KM) curves were used to analyze the effect of different triglycerides (TG) levels on survival in cirrhosis patients. Restricted cubic spline fitted Cox regression model was used to analyze the non-linear relationship between serum TG and patients' prognosis.ResultsPatients with AIH cirrhosis have lower TG levels compared to those without cirrhosis. And lower serum TG levels correlated with the severity of cirrhosis. Survival analysis showed that TG affected overall survival in AIH patients, with lower 5-year survival (Log-rank P < 0.05) in patients in TG ≤ 0.95 group (HR=3.79, 95% CI: 1.528-9.423). In addition, lower TG levels had a higher risk of death in patients with cirrhosis in AIH. In the interval of 0.5-0.8 mmol/L, the effect of TG on patient mortality showed a positive correlation. However, the risk of death was minimized when TG=0.8 mmol/L, and the effect of TG on patients plateaued when TG>0.8 mmol/L.ConclusionSerum TG levels can influence the onset and progression of AIH cirrhosis and may be used as a new indicator of prognosis in patients with AIH-related cirrhosis.
Therapeutic effect of intraosseous norepinephrine infusion in a minipig model of septic shock
Authors: Liu Yanyan , Li Xiaodan , Wang Yupeng , Wang Peng , Ma Qingbian , Zu Lingyun 
Published: September 2022

Abstract
Background
Studies have indicated that not every drug can achieve the same therapeutic effect or prognosis as intravenous injection when administered via intraosseous (IO) access. The purpose of this study was to establish an experimental minipig model of septic shock to compare the differences in the efficacy for the treatment of hypotension and survival time of IO and central venous catheter (CVC) infusions of norepinephrine.
Methods
Experimental minipigs were chosen for this study and were randomly divided into IO and CVC groups (n = 4 for each group). Cecal ligation and puncture was performed to establish the septic shock model. Immediately after the septic shock model was established, the IO group received norepinephrine via tibial IO infusion, whereas the CVC group received norepinephrine via internal jugular vein. The vital signs, blood pressure recovery time, post-septic shock survival time and total survival time were recorded.
Results
There was no significant difference in blood pressure recovery time between IO and CVC groups [40 (20–60) vs 30 (20–60) minutes, P = 0.686]. The cumulative norepinephrine dose during the period of blood pressure recovery time did not differ significantly between IO and CVC groups [10.0 (3.0–21.0) vs 6.5 (3.0–21.0) µg/Kg, P = 0.686]. There were no significant differences in the post-septic shock survival time [7.75 (6.50–10.00) vs 8.75 (6.50–14.00) hours, P = 0.686] and total survival time [21.25 (16.50–35.50) vs 25.75 (19.50–26.50) hours, P = 0.686] between IO and CVC groups.
Conclusion
These results suggest that tibial IO and CVC infusion of norepinephrine achieved same therapeutic effect on hypotension and survival time.