bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the prognostic value of 18F-FDG-PET/CT parameters　in head and neck cancer patients treated with definitive intensity modulated radiotherapy
Authors: Kawamura Mitsue , Yoshimura Michio , Mizowaki Takashi 
Published: February 2022

Abstract
Purpose

To investigate the treatment outcome and prognostic factor of volumetric parameters measured by 18F-FDG-PET/CT in squamous cell carcinoma patients of oropharynx, hypopharynx, and larynx treated with definitive intensity modulated radiotherapy.
Methods

We retrospectively reviewed 63 patients who received definitive radiation therapy for head and neck squamous cell carcinoma (HNSCC) between April 2007 and March 2012 in our hospital. Clinical factor and 18F-FDG-PET/CT parameters were evaluated using univariate and multivariate Cox regression analysis.
Result

With a median follow up of 61months (range 4-116 month), the 5-year overall survival (OS), progression-free survival (PFS) rate was 58.2%, and 63.0%, respectively. Recurrence was observed in 24 patients. Seventeen patients had locoregional recurrence and 9 patients developed distant metastasis. ROC analysis revealed the best threshold of pretreatment FDG-PET parameters was 14.8 of SUVmax, 5.4ml of metabolic tumor volume (MTV), and 38.5ml of total lesion glycolysis (TLG). On univariate analysis, MTV (>5.4ml), and TLG (>38.5ml) were predictive of poor OS (p<0.01, p<0.01) and poor DFS (p=0.01, p<0.01). On multivariate analysis, MTV displayed significantly worse effects on OS and DFS (p= 0.02, <0.01, respectively), while SUVmax was nonsignificant (p=0.70 for OS, p=0.70 for DFS).
Conclusion

This study showed that18F-FDG-PET/CT parameters are useful as prognostic factor of definitive intensity modulated radiotherapy of HNSCC. These prognostic factors may identify the population who have benefit from high intensity treatment, ex. dose escalation planning.
La restituzione di prestazioni secondo il nuovo art. 678 CO e il suo ruolo nel sistema delle operazioni con parti correlate
Authors: Humbel Claude 
Published: February 2022

La restituzione di prestazioni secondo l’art. 678 CO mira a ovviare a deflussi indebiti dal patrimonio societario di società anonime. Questo importante tassello della corporate governance svizzera è stato modificato nel contesto della riforma del diritto delle società anonime con l’obiettivo di rendere l’azione di restituzione più incisiva. Il presente articolo analizza la nuova norma e la pone nel contesto più ampio delle operazioni con parti correlate. Queste operazioni sono soggette a norme sempre più stringenti a livello internazionale, ma sono regolamentate solo selettivamente in Svizzera.
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Die Rückerstattung von Leistungen nach Art. 678 OR soll einen ungerechtfertigten Abfluss von Gesellschaftsvermögen verhindern. Dieses wichtige Element der schweizerischen Corporate Governance wurde im Rahmen der Aktienrechtsrevision mit dem Ziel geändert, die Rückerstattungsklage effektiver zu gestalten. In diesem Artikel wird die neue Regelung analysiert und in den breiteren Kontext der Geschäfte mit nahestehenden Personen gestellt. Diese Geschäfte unterliegen auf internationaler Ebene immer strengeren Vorschriften, sind in der Schweiz aber nur lückenhaft geregelt.
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La restitution des prestations selon l'art. 678 CO vise à empêcher transferts injustifiés d'actifs sociaux. Cet élément important de la gouvernance d'entreprise suisse a été modifié dans le cadre de la révision du droit de la société anonyme dans le but de rendre l'action en restitution plus efficace. Le présent article analyse la nouvelle réglementation et la replace dans le contexte plus large opérations entre parties liées. Ces opérations sont soumises à des règles de plus en plus strictes au niveau international, mais ne sont réglementées que de manière lacunaire en Suisse.
Emergency treatment in gynecology using different methods of surgery
Authors: Pikul Iuliia , Lubkovska Oleksandra 
Published: February 2022

The aim. Improving surgical treatment of urgent genital pathology based on comparing the effectiveness of different methods of surgery.
Materials and methods. 170 women were selected and divided into three groups. Group 1 included women with acute pelvic inflammatory disease (aPID); to 2nd group – 60 women with intra-abdominal bleeding (IAB); to 3rd group - 50 women with impaired blood supply to tumors of the internal genitalia (uterus and ovaries) (IBSTIG). Each group was divided into two equivalent subgroups depending on the method of treatment: laparoscopic or laparotomy.
During the study, all examined patients had a medical history, gynecological examination, ultrasound examination, surgical treatment by laparoscopy or laparotomy.
Results. The average duration of laparoscopic operations in patients in subgroup 1.1 was 50.4±7.2 minutes and 80.3±10.1 minutes in subgroup 1.2 – with laparotomy method. Intraoperative blood loss was significantly lower in subgroup 1.1 compared with subgroup 1.2 (210.7±31.4 ml and 375.9±44.5 ml) (p <0.01). In the postoperative period in subgroup 1.1, which included women with emergencies due to aPID and in which operations were performed laparoscopically, the maximum temperature rise after surgery was 37.6±0.04 °C, which was significantly lower than in subgroup 1.2, which included women with emergencies due to aPID and in which operations were performed by laparotomy, this figure was 38.0±0.08 °C (p <0.001). The mean duration of the postoperative period in patients of subgroup 1.1 was significantly shorter compared to subgroup 1.2 (7.2±0.6 and 10.2±1.0 days) (p <0.05).
The average duration of operations in subgroup 2.1 was significantly shorter than in subgroup 2.1 (39.8±2.1 and 59.1±2.5 minutes, respectively) (p <0.001). Intraoperative blood loss was on average significantly lower in subgroup 2.1 (189.1±19.8 and 388.5±37.2 ml, respectively) (p <0.05).
In subgroup 3.1, which included women with IBSTIG and underwent surgical treatment by laparoscopy, the average duration of operations was significantly shorter than in subgroup 3.2, where such women with such pathology received surgical treatment by laparotomy (62.1±4.9 and 89.6±7.8 minutes, respectively) (p <0.01). Blood loss was significantly lower in subgroup 3.1 in contrast to subgroup 3.2 (101.7±10.1 ml and 283.3±12.9 ml, respectively) (p <0.001).
Conclusions. The use of laparoscopy for the treatment of urgent genital pathology could increase the effectiveness of surgical treatment. In addition, this method reduces the duration of surgery and surgical blood loss. As a result, it makes it possible to improve the postoperative period.
The impact of the COVID-19 pandemic, online-learning on the state of visual system and psychological state of students
Authors: Kushch Yuliia 
Published: February 2022

The aim of this study: to identify and analyze changes in the lifestyle and psychological sphere of students who are undergoing online training in quarantine isolation due to the COVID-19 pandemic.
Material and methods: 160 students were examined for the myopic refraction using the Duochrome Test, as well as shifts in the quality of vision as a result of online learning. All participants were also interviewed to ascertain living conditions and psychological status during domestic learning related to COVID-19 isolation.
Result: it was found that 42.5 % participants have myopia, most of them students of 1 and 4 courses (26.5 % and 30.9 %, respectively). 85.6 % respondents noted deterioration in health after long-term visual work with personal computer and/or smartphone. The leading symptoms associated with work on digital displays were: decreased visual acuity and binocular vision disorders (81.9 %), headache (75.6 %), back muscle pain (71.9 %), eyes redness (55.6 %), dry and itchy eyes (45 % of respondents). It has been established what 75.6 % respondents indicated deterioration in their psychological condition as a result of quarantine restrictions: 68.1 % – stress, 48.8 % – emotional instability (irritability), 51.9 % – sleep disorders (insomnia), 16.3 % – depression. It is determined that daily average working time in the conditions of domestic online learning was 6.4±2.6 hours (compared to 4.1±1.7 hours in the pre-quarantine period).
Conclusion: revealed deterioration in the quality of vision, general well-being and the psychological sphere of students who are undergoing online quarantine training due to the COVID-19 pandemic.
Features of the clinical course of acute otitis media in patients with impaired carbohydrate metabolism
Authors: Pochuiеva Tatiana , Filatova Anna , Filatova Iryna 
Published: February 2022

The aim of the research: study of the features of the clinical course of acute otitis media (AOM) in patients with impaired carbohydrate metabolism.
Materials and methods. We examined 140 patients with AOM aged 19 to 72 years, of which 75 patients with impaired carbohydrate metabolism constituted the main group and 65 patients were included in the comparison group. Taking into account the peculiarities of the pathogenesis of AOM and disorders of carbohydrate metabolism, patients were randomized into 4 groups: 1 – patients with AOM (36), 2 – patients with AOM on the background of sinusitis (29), 3 – patients with AOM on the background of non-insulin-dependent diabetes mellitus (DM type II) (37), 4 – AOM patients with impaired glucose metabolism (38). The patients underwent a general clinical examination, determination of glycosylated hemoglobin, leukocyte indices of intoxication, audiometry, computed tomography (CT) of the temporal bones (if indicated).
Results. The proportion of patients with impaired carbohydrate metabolism in 2020 was 32.6 %, of which DM type II was diagnosed in 49.3 % earlier. It was shown that a feature of the clinical course of AOM against the background of impaired carbohydrate metabolism is the discrepancy between the duration of the disease history, complaints and objective data to the state of the cellular structure of the mastoid process according to CT data and impaired auditory function mainly by the type of sound perception, which indicates the formation of latent mastoiditis. Clinically significant complaints and objective data for the differential diagnosis of latent mastoiditis in these patients were determined. The absence of statistical significance of differences in indicators in patients with DM type II and against the background of transient hyperglycemia was revealed, and the concept of the latter was characterized. A direct correlation between blood glucose levels and glycated hemoglobin levels was established in patients with DM type II and AOM.
Conclusions. DM type II creates a favorable background for the formation of the clinical course of AOM complicated by latent mastoiditis.
From the general contingent of patients with AOM, patients should be distinguished not only with DM type II, but also with transient hyperglycemia for its timely diagnosis. Significant symptoms: pain and a feeling of “heaviness” in the behind-the-ear region in the absence of reactive phenomena, a feeling of “pulsation” in the ear, dizziness, a cloudy eardrum with a protrusion or perforation in the posterior or posterior-upper section, an asymmetric increase in sound perception thresholds above 25 dB. Such patients should be observed with “early” CT scan of the temporal bones.
Chemo-enzymatic Approach to Carbohydrate Recognition
Authors: Takayama Shuichi , Wong Chi-Huey 
Published: February 2022

Abstract:
Carbohydrates are widespread in biological systems and are often associated with many specific recognition and signaling processes that lead to important biological functions and diseases. Considerable efforts have been directed toward understanding and mimicking such recognition processes, and developing effective agents to control these events. The pace of discovery research in glycobiology and development of carbohydrate-based therapeutics, however, has been relatively slow compared to that of other classes of biomolecules due to the lack of appropriate strategies and methods available for carbohydrate­ related research. This review summarizes some of the most recent developments in the field of carbohydrate research, with particular emphasis on the work from our laboratories regarding the use of chemo-enzymatic strategies to study carbohydrate recognition. Highlights include the the chemo-enzymatic synthesis of complex carbohydrates and glycoproteins, the rational and combinatorial synthesis of carbohydrate mimetics as inhibitors of selectins and viral RNA, and design and synthesis of mechanism-based inhibitors of glycoprocessing enzymes.
Marine Natural Products Influencing Larval Settlement and Metamorphosi of Benthic Invertebrates
Authors: Fusetani Nobuhiro 
Published: February 2022

Abstract:
Most benthic invertebrates produce planktonic larvae, which swim or float for a while and embark on search for location to settle and metamorphose. Many factors influence this process, among which chemical cues derived from conspecific adults or prey organisms are believed to be important; larvae start to settle in response to chemical cues. Although various compounds have been reported to induce larval settlement and
metamorphosis for many species, those which real chemical cues have been known are quite few. On the other hands, settlement of larvae of other species endangers the survivorship of benthic organisms which in turn possess chemical defense against larval settlement. An array of marine natural products have been obtained as inhibitors of settlement of the barnacle Balanus amphtirite which is one of most popular fouling organisms. Since the Fusetani Biofouling Project started in October 1991, we have been trying to discover from marine organisms compounds which induce larval settlement and metamorphosis of the ascidian Halocynthia roretzi, which resulted in the isolation of more than 40 active metabolites including simple benzenoids, alkaloids, amino acid derivatives, and polyacetylenes. These compounds were found to mimic a real cue, lumichrome. We have also attempted to isolate antibarnacle metabolites from sessile marine organisms, mainly sponges and nudibranchs. More than 60 active substances including terpenoids, steroids, amino acid derivatives, alkaloids, and polyacetylenes have been obtained. Sesqui- and diterpenoids containing isocyano and related functionalities showed potent activity, but their toxicity was low, thus suggesting their promising properties for nontoxic antifoulants.
Isocyanide Based Multi Component Reactions in Combinatorial Chemistry
Authors: Dömling Alexander 
Published: February 2022

:
Although usually regarded as a recent development, the combinatorial approach to the synthesis of libraries of new drug candidates was first described as early as 1961 using the isocyanide-based one-pot multicomponent Ugi reaction. Isocyanide-based multi component reactions (MCR's) markedly differ from their usual two component counterparts. In the context of combinatorial chemistry, they offer more structural variations, more accessible compounds and more diversity than any other previously known reaction. This review examines the history of isocyanide based MCR's and their applicability in combinatorial chemistry.
Effect of Different Homework on Chronic Morbidity among Single Older People
Authors: Arkhipov Viktor , Aringazina Altyn 
Published: February 2022

Background:
A solid evidence base supports the positive relationship between regular physical activity and health, and studies have largely examined the effects of brisk walking, leisure-time exercise, or occupational activity rather than domestic activities.

Objective:
Determine how housework and physical activities (gardening, harvesting water and firewood (for winter), cleaning of the whole house, shopping) affect the development of morbidity among the elderly population.

Materials and Methods:
The 2481 members of the community were taken from two cities of the Turkestan region, Shimkent and Turkestan. For contingency tables, the χ2 criterion was used to assess the significance of differences between the actual (identified as a result of the study) quantitative or qualitative characteristics of the sample falling into each category and the theoretical amount that can be expected in the study groups if the null hypothesis is true.For multi-table tables have used Cramer’s V criterion V.

Results:
Gardening and Shopping showed a weak relationship between these variables at 48.9 and 36.8% with confidence levels p = 0,001 and 0,0001, respectively. V Cramer showed a weak bond at 0.13-0.12 for both variables. Collection of water and firewood (for winter) and cleaning of the whole house/apartment, illustrates the absence of any connection between the nominal variables under investigation and the frequency at cm2 5.6-16.4 with the confidence level p = 0,0003 -0,001, respectively.

Conclusion:
As can be seen from the above results, physical activity particularly housework does not obviously show a connection in the development of chronic morbidity among single elderly people.
Out-patient Visit to the Pulmonologist: Peculiarities of Medical Pare Provision amid the COVID-19 Pandemic
Authors: Chaplynska Nataliia , Rudnyk Viktoriya , Pozur Nataliya 
Published: February 2022

Abstract. The coronavirus pandemic has significantly affected the health care system and continues to make adjustments to the work of physicians in various specialties.
The aim of the study was to analyze the work of a pulmonologist of the polyclinic amid the pandemic COVID-19.
Material and methods of the study. An assessment of appeals to the pulmonologist consultation in the medical center “Frankomed” in Ivano-Frankivsk from July 2020 to February 2021 has been performed.
Research results.There were 143 patients, who made 185 visits and applied for an appointment with a pulmonologist within 8 months. Among those studied there were 72 women and 71 men. The age of patients was from 18 to 87 years, the average age of women was 49.31 ± 2.14 years, the average age of men was 48.86 ± 2.73 years.
The reasons for seeking medical help from a pulmonologist were the following ones: acute bronchitis – 5 (2.73%), exacerbation of chronic bronchitis – 54 (29.51%), COPD – 12 (6.56%), bronchial asthma – 8 (4.37) %), pneumonia – 42 (22.95%), coronavirus disease – 30 (16.39%), idiopathic pulmonary fibrosis – 2 (1.09%), tuberculosis – 6 (3.28%), neoplasms – 3 (1.63%), metastatic lung damage– 1 (0.55%), pneumofibrosis – 18 (9.84%) cases.
The vast majority of appeals is accounted for the chronic non-specific pulmonary pathology, namely chronic bronchitis, COPD, etc. All pulmonary beds of the region during the COVID-19 pandemic were repurposed to Covid ones, specialized diagnostic and therapeutic care could not be provided to such patients.
In the second place there are coronavirus disease, pneumonia and post-pneumonic pneumofibrosis. The reasons for such patients’ appeals were their desire to receive a consultation of a narrow specialist, excessive workload of family doctors, and others.
Isolated cases of tuberculosis and neoplasms of unknown etiology were reported. The latter patients were immediately advised to consult TB and thoracic specialists.
Conclusions. During the coronavirus infection pandemic, temporary restrictions led to later visits to a pulmonologist in case of exacerbations, which could provoke the development of life-threatening conditions and required hospitalization.
Patients who applied to the medical center, had the opportunity to get the professional opinion and treatment.
Important work was done by a pulmonologist to identify important medical-social problems.
Key-words: outpatient, pulmonologist, COVID-19
AICLE
Authors: Castilla Maqueda Linda Sofía 
Published: February 2022

El presente artículo explica en forma breve cómo en México la enseñanza de español se aborda como una materia aparte y las clases aún son demasiado gramaticales, con escaso énfasis en las cuatro destrezas lingüísticas, además de que se toman muy poco en cuenta las nuevas preferencias de aprendizaje. Por estos motivos resulta pertinente presentar la filosofía de estudio AICLE, la cual integra la enseñanza de un idioma como medio para el aprendizaje de contenidos curriculares, utilizando recursos tecnológicos.
Esta filosofía bien puede ser empleada en cursos de español, aunque ha sido utilizada principalmente para aprender inglés. Primero se describen sus orígenes, aspectos clave, así como sus ventajas y desventajas. También se explica el material didáctico diseñado siguiendo los lineamientos AICLE, enfocado en particular en la enseñanza del español como segunda lengua a nivel independiente (B1 del MCRL), así como algunos sucesos de la historia de México. Por último se exponen las conclusiones.
Identidades cronotópicas
Authors: Blommaert Jan , De Fina Anna 
Published: February 2022

Este trabajo revisa, amplía y elabora en forma considerable un argumento trazado en avances de investigación anteriores (Blommaert, 2015b; De Fina, 2015), que a su vez desarrolla lo planteado en Blommaert y Varis (2015). Nuestra gratitud para Ben Rampton, Piia Varis, Ico Maly, Jef Van der Aa, Max Spotti, Rob Moore, Sjaak Kroon, y Jos Swanenberg por las numerosas discusiones sobre los temas abordados en este trabajo.
Traducción del texto (2017) Chronotopic Identities: On the Timespace Organization of Who We Are. En A. De Fina, J. Wegner y D. Ikizoglu (Eds.), Diversity and Super-diversity. Sociocultural Linguistic Perspectives (1-15). Georgetown University Press. Agradecemos a Georgetown University Press por otorgar los permisos para la traducción y publicación de este capítulo. Traducción de Emma Jiménez Llamas y Alejandra Silva Lomelí.
La puesta en escena en el aula de Enseñanza del Español como Lengua Extranjera (ELE)
Authors: Gutiérrez Martínez María del Socorro 
Published: February 2022

Este trabajo propone el uso del espacio vacío para el aprendizaje del español como lengua extranjera (ELE), tomando como marco teórico las ideas de Peter Brook (2014) y la puesta en escena en la clase ELE como metodología y recurso pedagógico. Se muestra en este texto el trabajo de campo llevado a cabo en una presentación en el aula, cómo se utilizaron elementos y objetos de uso habitual en la clase, la puesta en escena y el arte de las expresiones oral, visual, corporal y auditiva, que componen las perspectivas del trabajo del Marco Común Europeo de Referencia para las lenguas: aprendizaje, enseñanza y evaluación (MCER). Se propone el empleo de aquellos elementos que la escenificación proporciona y que se tienen al alcance en el aula. Se plantea la investigación-acción, que muestra las posibilidades pedagógicas que pueden mejorar la atmósfera en el grupo, el desarrollo de la afectividad, la concentración, la gramática en acción y el aprendizaje colaborativo en un ámbito intercultural por medio de la puesta en escena y de la utilización del espacio siguiendo los postulados de Brook
AUTOEFICÁCIA DOCENTE E O ENSINO DE EDUCAÇÃO FÍSICA NA PERSPECTIVA DA INCLUSÃO:
Authors: Firmino Magalhães Barbosa Raquel , Xavier da Silva Kátia Regina 
Published: February 2022

Autoeficácia diz respeito à crença nas próprias capacidades para realizar ações, seja em áreas de domínio específicas, seja em situações mais genéricas em múltiplas áreas, sobretudo no campo pedagógico do ensino. Estudos apontam que as crenças de autoeficácia dos professores em ensinar influenciam a motivação e as crenças de autoeficácia dos estudantes para aprender. Este relato de experiência tem como objetivo apresentar algumas relações entre a autoeficácia docente para o ensino de Educação Física e o uso de estratégias para a inclusão de um aluno surdo de 1º ano do Ensino Médio, em uma Instituição Pública de Ensino da Rede Federal do Rio de Janeiro. O texto aborda questões ligadas ao currículo, às interações sociais e caminhos para garantir o direito à aprendizagem.
Palavras-chave: Autoeficácia. Criatividade. Inclusão. Educação Física Escolar. Narrativas Autobiográficas.