bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food Estate Program Law Politics
Authors: Wisnu Ditta 
Published: April 2022

This study aims to determine the implications of the food estate program on the fulfillment of the rights of the Dayak people of Central Kalimantan and the legal policy of the preparation and implementation of the National Economic Recovery Program (NERP) through the Food Estate in Central Kalimantan in line with the principles of human rights and traditional values of the Central Kalimantan Dayak. The type of research used in compiling this research is empirical normative juridical research. This research is descriptive. The types of data used are primary data and secondary data. Primary data collection techniques through interviews while secondary data obtained through library research. Primary and secondary data were analyzed qualitatively. The results of the study show that: First, the Food Estate Program in Central Kalimantan, which is one of the national economic recovery programs (NERP) has had a significant impact on the indigenous Dayak people of Central Kalimantan who have ties to forests, land and rivers as well as causing vertical and horizontal conflicts in their lives’ implementation. Second: the Central Government and Local Governments in formulating regulations and policies, on the one hand, have the enthusiasm to pay attention to the customary values and traditions of the Dayak indigenous people of Central Kalimantan but are weak at the implementation stage, causing conflicts due to the issuance of Law of the Republic of Indonesia No. 11 of 2020 concerning Job Creation and its derivative regulations that put forward the principle of omnibus law which aims to create a quality business and investment climate without paying attention to the principles of human rights, ecological justice and the customary values and traditions of the Dayak people of Central Kalimantan.
Keywords: Legal policy, Human Rights, Ecological Justice.
Why promising drugs are shelved and barriers and facilitators to their re-purposing: A systematic literature review
Authors: Krishnamurthy Nithya , Grimshaw Alyssa A. , Axson Sydney A. , Choe Sung Hee , Miller Jennifer E 
Published: April 2022

Abstract
Background: Repurposing is a drug development strategy receiving heightened attention after the FDA granted emergency use authorization of several repurposed drugs to treat Covid-19. There remain knowledge gaps on facilitators and barriers for repurposing and why promising drug candidates get shelved in the outset. Method: This systematic literature review used controlled vocabulary and free text terms to search ABI/Informa, Academic Search Premier, Business Source Complete, Cochrane Library, EconLit, Google Scholar, Ovid Embase, Ovid Medline, Pubmed, Scopus, and Web of Science Core Collection databases for the characteristics, reasons and example of companies deprioritizing development of promising drugs and barriers, facilitators and examples of successful re-purposing. Results: We identified 11,814 articles, screened 5,976 for relevance, found 437 eligible for full text review, 115 of which were included in full analysis. Most articles (66%, 76/115) discussed why promising drugs are abandoned, with lack of efficacy, or superiority to other therapies, for the studied indication (n=59), strategic business reasons (n=35), safety problems (n=28), research design decisions (n=12), the complex nature of a studied disease or drug (n=7) and regulatory bodies requiring more information (n=2) among the top. Repurposing barriers include inadequate resources (n=42), expertise (n=11), intellectual property challenges (n=26), poor data access (n=20), uncertainty about the value of repurposing (n=13), and liability risks (n=5). Repurposing facilitators include multi-partner collaborations (n=38), access to compound databases and corresponding screening tools (n=32), regulatory modifications (n=5), and tax incentives (n=2).Conclusion: Sponsors deprioritize development of promising drugs due to insufficient efficacy or superiority to other therapies for studied indications or populations, perceived market prospects, and industry consolidation. Inadequate resources and data access and challenges negotiating IP are key barriers needing reform for repurposing to reach its full potential as a core approach in drug development. Multi-partner collaborations and the creation, accessibility, and use of compound databases and tax incentives are key facilitators for repurposing. More research is needed on the current value of repurposing in drug development and how to better facilitate resources to support it, where valuable, especially financial, staffing for out-licensing shelved products, and legal expertise to negotiate IP agreements in multi-partner collaborations.Registration: The protocol was registered on Open Science Framework (https://osf.io/f634k/) as it was not eligible for registration on PROSPERO.
Protocol for a hybrid II study exploring the feasibility of delivering, evaluating, and implementing a self-management programme for people with neuromuscular diseases at a specialist neuromuscular centre (ADAPT-NMD)
Authors: Lee Laurence Edward , Kulnik Stefan Tino , Curran Geoffrey M , Boaz Annette , Ramdharry Gita M 
Published: April 2022

Abstract
Background: Self-management support (SMS) forms a central pillar in the management of many long-term conditions. It is firmly aligned with national health policy but there is a paucity of evidence exploring how it is enacted in the context of neuromuscular diseases (NMDs). Bridges is a SMS programme originally developed in stroke. A new version of the programme (Neuromuscular Bridges) has recently been developed in collaboration with people with lived experience of NMD using co-design methods and requires evaluation. The implementation of SMS is inherently complex with potential barriers at the level of the patient, provider, and wider organisation. The success of implementing programmes can be highly dependent on context, indicating a rationale for considering implementation determinants at an early stage. This study aims to explore the feasibility of delivering and evaluating Neuromuscular Bridges, whilst simultaneously testing the feasibility of an implementation strategy bundle for a specialist neuromuscular centre. Methods:This study employs a hybrid II design underpinned by Normalisation Process Theory (NPT), which has been used prospectively to inform the implementation plan and will be invoked in the analysis. The feasibility of delivering and evaluating Neuromuscular Bridges will be assessed using a single-arm pre-post design. We will explore acceptability, demand within the service, performance of outcome measures, recruitment, and retention. Implementation strategies have been selected from a refined taxonomy of strategies, mapped to NPT, and targeted at known barriers and facilitators at the specialist centre that were identified from preliminary stakeholder engagement activities. The impact of the strategy bundle on fidelity, acceptability, appropriateness, and adoption will be evaluated using qualitative interviews, administrative data, surveys, and a notes audit. ConclusionsThis this study will provide valuable feasibility data on a co-designed SMS programme for people with NMDs and enhance understandings of factors and requirements for delivering, evaluating, and implementing it at a specialist centre. Using hybrid methodology at the feasibility stage is unusual and this study will provide important insights into the usefulness of taking this approach at this point in the research pipeline. Trial registration This trial was registered with ISRCTN. Trial ID: ISRCTN14208138 Date registered: 18/08/2021. Link: https://www.isrctn.com/ISRCTN14208138
Natural Resource Rents, Globalisation and Environmental Degradation: New Insight from 5 Richest African Economies
Authors: Aladejare Samson 
Published: April 2022

Abstract
Environmental degradation has continued to be a major global challenge; hence, it is consistently drawing attention from policymakers and academics. Therefore, this study further contributes to the literature by investigating the contributions of natural resource rents and globalisation to environmental degradation in the 5 richest African economies from 1990 to 2019. Four techniques were applied: the fixed and random effect, feasible generalised least squares and the augmented mean group. The Hausman test was used to affirm the supremacy of the feasible generalised least squares outcomes and, consequently, its use to derive the study inferences. A Dumitrescu and Hurlin causality test was also employed to determine the direction of causality between the subject variables. Findings from the study showed that natural resource rents significantly contribute to environmental degradation. In contrast, globalisation reduces environmental degradation. Urbanisation, which served as a control measure, enhanced environmental sustainability. Robustness checks on the study models revealed the validity and reliability of the models' inferences. The Additional outcomes from the robustness checks revealed that while economic growth has no substantial effect on environmental degradation, human capital development significantly worsens the environment. The study highlights relevant policy actions that could substantially reduce environmental degradation.
Derivation of 1.064 μm albedo on the C-type asteroid Ryugu from laser pulse intensity measurement of the Hayabusa2 LIDAR
Authors: Yamada Ryuhei , Yamamoto Keiko , Oshigami Shoko , Araki Hiroshi , Senshu Hiroki , Noda Hirotomo , Namiki Noriyuki , Matsumoto Koji , Yoshida Fumi , Abe Shinsuke , Hirata Naru , Sasaki Sho , Mizuno Takahide 
Published: April 2022

Abstract
Japanese asteroid explorer Hayabusa2 arrived at C-type asteroid 162173 Ryugu in June 2018. Laser altimeter (LIDAR) onboard Hayabusa2 measured its own transmitted laser pulse intensity and returned pulse intensity from the surface of Ryugu until November 2019. Because the Ryugu surface is extremely rough, topography dominates material property in the conventional derivation of normal albedo. We develop a method to derive the albedo from the rough surface of the C-type asteroid at the LIDAR laser wavelength of 1.064 μm. Using the intensity data obtained before the conjunction of the spacecraft with the Sun, the albedo map covering an equatorial band between – 40˚ and + 20˚ in the latitude is created with 2˚ by 2˚ resolution. The average of the albedo is 0.0406 [[EQUATION]] 0.0031, while about half of them are in the range between 0.04 and 0.045. The low and uniform albedo feature is common to other remote-sensing observations of Ryugu by visible and near-infrared cameras onboard the Hayabusa2.
Supercapsular percutaneously-assisted approach versus conventional posterolateral approach for primary total hip arthroplasty: a prospective randomized controlled trial
Authors: Gan Feng-Ping , Yang Ke-Qin , Zhang Qi-Biao , Lin Xin-Xin , Xie Zhao-Lin , Luo Xiang , Zeng Yi-Rong 
Published: April 2022

Abstract
Background
Supercapsular percutaneously-assisted total hip (SuperPATH) approach has been regarded as as one of minimally invasive and muscle sparing technique, whcih accesses the hip maintaining integrity of the external rotators and capsule.The purpose of this study was to compare the SuperPATH approach with the conventional posterolateral approach in terms of early clinical outcomes and radiological results.
Methods
This prospective randomized controlled single blinded study enrolled patients who underwent unilateral primary THA between March 2018 and December 2019.The demographic data,perioperative status [operative time, incision length, total blood loss, serum marker, and length of hospital stay (LHS)], pain visual analog scale (VAS), and Harris Score (HS) were evaluated and compared between the groups.
Results
Compared with the PLA group, the SuperPATH group had a shorter incision length, lower pain VAS sores within 1 months and better HS within 3 months after operation,the difference was statistically significant(P < 0.05).However, the SuperPATH group had a longer operative time ,more total blood loss,the difference was statistically significant(P < 0.05).The mean complication rate, blood transfusion rate and LHS were similar between two groups(P > 0.05).The VAS and HS were similar between the two groups at 1 year after surgery(P > 0.05). Serum levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and creatine kinase(CK) (within 2 weeks postoperatively) were similar between the groups(P > 0.05). The SuperPATH group had a larger acetabular inclination and anteversion(P < 0.05),but it was all within Lewinnek’s safe zone.Leg length discrepancy > 1 cm were more common in the SuperPATH group,but the difference was not significant(P > 0.05).
Conclusion
This study reveals that the SuperPATH technique was associated with lower pain levels, and higher physical function than conventional posterolateral approach .However, it had a longer operative time and more blood loss.
Palliative Care Outpatients in a German Comprehensive Cancer Center - Identifying Indicators for Early and Late Referral
Authors: Mueller Sandy , Fink Madeleine , Hense Joerg , Comino Maria Rosa Salvador , Schuler Martin , Teufel Martin , Tewes Mitra 
Published: April 2022

Abstract
Purpose. Despite that early integration of palliative care is recommended in advanced cancer patients, referrals to specialised palliative care (SPC) frequently occur late. Well-defined referral criteria are still missing. We analysed indicators associated with early (ER) and late referral (LR) to SPC of a high volume outpatient unit of a German comprehensive cancer center.Methods. Characteristics, laboratory parameters and symptom burden of 281 patients at first SPC referral were analysed. Timing of referral was categorized as early, intermediate and late (>12, 3-12 and < 3 months before death). Ordinal logistic regression analysis was used to find factors related to referral timing. Kruskal-Wallis test was used to determine symptom severity and laboratory parameter in each referral category. Results. LRs (50.7%) had worse scores of weakness, loss of appetite, drowsiness, assistance of daily living (all p < 0.001) and organisation of care (p < 0.01) in contrast to ERs. The mean symptom sum score was significantly higher in LRs than ERs (13.03 vs. 16.08; p < 0.01). Parameters indicative of poor prognosis, such as elevated LDH, CRP and neutrophil-to-lymphocyte ratio (NLR) (p < 0.01) as well as the presence of ascites (p < 0.05), were significantly higher (all p < 0.001) in LRs. In univariable analyses, psychological distress (p < 0.05) and female gender (p < 0.05) were independently associated with an ER.Conclusion. A symptom sum score and parameters of poor prognosis like NLR or LDH might be useful to integrate into palliative care screening tools.
Comparison of Primary Radiographic Patterns of Ameloblastoma in Patients with and without Recurrence of Tumor
Authors: Razmara Farnoosh , Aleedawi Zainab Abdulkareem , Mosavat Farzaneh , Kharazifard Mohammad Javad 
Published: April 2022

Abstract
Background: Due to the lack of comprehensive research on the relationship between preliminary radiographs and tumor recurrence, this study was conducted to bring light to the correlation between radiographic findings and ameloblastoma lesion recurrence, surgical method, and jaw reconstruction. Methods: The medical records of 96 patients who were surgically treated for ameloblastoma tumor in Shariati and Sina hospitals in Tehran, over a span of 8 years; 2014-2021, were collected both manually and electronically from the hospitals’ archives. Only 50 patients were included, 27 female and 23 male patients. The mean age of the patients was 36 years (range, 10 to 82 years). Each case has been evaluated and reviewed based on the CBCT Scans and Panoramic radiographs by a specialized oral and maxillofacial radiologist. The patients have been contacted for a follow up to the specialized clinic of maxillofacial surgery of Shariati hospital to assess for a recurrence. Results: Our study revealed that the primary treatment modality (p= 0.051), the primary reconstruction treatment (p=0.007), tumor localization (p= 0.032), primary radiographic patterns (p=0.009), bone expansion (p=0.016) and cortical bone invasion (p=0.029) have a significant association with tumor recurrence. Conclusion: To accomplish accurate results regarding risk factors of ameloblastoma recurrence; a larger number of subjects and studies required, as well as extended long term follow up. We propose to bring the light on which each of primary radiographic patterns, primary treatment modality, primary reconstruction treatment, tumor localization, bone expansion and cortical bone invasion is related to the recurrence of the tumor to be considered during surgical treatment plan and to be collected in one meta-analysis in the future.
Anti-apoptotic effect of adrenomedullin gene delivery on Leydig cells by suppressing TGF-β1 via the Hippo signaling pathway
Authors: Hu Wei , Luo You-wen , Zhu Xia-lian , Li Ming-yong , Zhou Jian-hua , Yang Zhi-min , Tong Tao , Chen Bing-hai , Qin Song-lin , Liu Bo-long 
Published: April 2022

Abstract
To investigate whether adrenomedullin (ADM) rescues the steroidogenic functions of Leydig cells by suppressing transforming growth factor-β1 (TGF-β1) via the Hippo signaling. Primary Leydig cells were treated with lipopolysaccharide (LPS), an adeno-associated virus vector that expressed ADM (Ad-ADM) or sh-RNA of TGF-β1 (Ad-sh-TGF-β1). Cell viability and medium concentrations of testosterone were detected. Gene expression and protein levels were detected for steroidogenic enzymes, TGF-β1, RhoA, YAP, TAZ and TEAD1. Role of Ad-ADM in the regulation of TGF-β1 promoter was confirmed by ChIP and Co-IP. Like Ad-sh-TGF-β1, Ad-ADM reversed the decreased number of Leydig cells and plasma concentrations of testosterone by rescuing the gene and protein levels of SF-1, LRH1, Nur77, StAR, P450scc, 3β-HSD, CYP17 and 17β-HSD. Similar to Ad-sh-TGF-β1, Ad-ADM inhibited the LPS-induced cytotoxicity and cell apoptosis and rescued the gene and protein levels of SF-1, LRH1, Nur77, StAR, P450scc, 3β-HSD, CYP17, 17β-HSD and the medium concentrations of testosterone in LPS-induced Leydig cells. Like Ad-sh-TGF-β1, Ad-ADM ameliorated LPS-induced TGF-β1 expression. In addition, Ad-ADM inhibited RhoA activation, enhanced the phosphorylation of YAP and TAZ, decreased TEAD1 expression which interacted with HDAC5 and then bound to TGF-β1 gene promoter in LPS-exposed Leydig cells. ADM may exert anti-apoptotic effect to rescue the steroidogenic functions of Leydig cells by suppressing TGF-β1 via the Hippo signaling.
ERRα protects against sepsis-induced acute lung injury in rats
Authors: Xia Wenfang , Pan Zhou , Zhang Huanming , Zhou Qingshan , Liu Yu 
Published: April 2022

Abstract
Sepsis-induced acute lung injury (ALI) is associated with poor survival rates. The identification of potential therapeutic targets for preventing sepsis-induced ALI has clinical importance. Here, we show that estrogen-related receptor alpha (ERRα) protects against sepsis-induced ALI through ERRα-mediated apoptosis and autophagy. ERRα was upregulated in inflammation models from lipopolysaccharides (LPS)-treated rat pulmonary microvascular endothelial cells (PMVECs) and cecal ligation and puncture (CLP)-induced septic rats. In vitro , overexpression of ERRα ameliorated LPS-induced degradation of adherens junctional molecules, upregulation of bax, cleaved caspase 3 and cleaved caspase 9 levels and downregulation of anti-apoptotic protein Bcl-2 level, and promoted the formation of autophagic flux, while the knockdown of ERRα exacerbated LPS-induced apoptosis and inhibited the activation of autophagy. Rats injected with ERRα agonist were subjected to CLP to elucidate the role of ERRα in sepsis-induced ALI in vivo . Administration of ERRα agonist alleviated the pathological damage of lung tissue, increased the levels of tight junction proteins and adherens junction proteins, and decreased the expression of apoptosis-related proteins. Promoting the expression of ERRα significantly enhanced the process of autophagy and reduced CLP-induced ALI. Mechanistically, ERRα is essential to regulate the balance between autophagy and apoptosis to maintain the adherens junctional integrity. These findings indicate that activation of ERRα provides a new therapeutic opportunity to prevent sepsis-induced ALI.
Evaluation of the performance of Chilean nursing homes against COVID-19
Authors: Singer Marcos 
Published: April 2022

Abstract
Background: The COVID-19 pandemic hit Chile in March 2020, in the midst of the worst political and social crisis it had suffered in the last 40 years. The causes of the crisis, related to weak social cohesion, were in part the cause of Chile's poor performance in terms of deaths from the pandemic. Unlike the rest of the country, in the case of Chilean nursing homes, three levels of cohesion were achieved: the state, businesses and civil society. We explained in detail how each of these groups provided strategic capabilities that achieved a much higher than expected performance.Methods: Based on information from 18 developed countries and 60 regions (states of the USA, countries of the UK and regions of Spain), we postulated a number of statistical models, quadratic and exponential, to explain deaths in nursing homes as a function of deaths in their geographical area.Results: Knowing that by September 2020, 1,258 elderly people had died, with 95% confidence we deduce that slightly more than 400 were saved. Compared to the 78 countries and regions considered, this makes Chile's nursing homes the fourth best performers.Conclusions: This study demonstrates the importance of social cohesion in facing major challenges such as the battle against COVID-19 in Chile's care homes.
Transplantation of human adipose derived stem cells with co- overexpressed Leukemia inhibitory factor and beta interferon promote recovery in experimental autoimmune encephalomyelitis (EAE)
Authors: Yousefi Mahdieh , Nabipour Abolghasem , Hakemi Mazdak Ganjalikhani , Ashja-Arvan Mehnoosh , Amirpour Noushin , Salehi Hossein 
Published: April 2022

Abstract
Multiple Sclerosis (MS) is the most common demyelinating disease with inflammatory demyelination in central nerve system (CNS). Beside the defect in myelin repair process, the balance change in inflammatory and anti- inflammatory cytokines is one of the most significant factors in MS pathogenesis. This study aimed at evaluating the effects of co-overexpressing beta interferon (IFN-β) and Leukemia inhibitory factor (LIF) in human adipose derived stem cells (IFN-β/LIF-hADSCs) on the experimental autoimmune encephalomyelitis (EAE). 12 days after the induction of EAE on female mice C57Bl/6 with MOG35-55 and the emergence of primary clinical signs, the IFN-β/LIF-hADSCs were injected though the mice tail vein of the EAE mice. The mice were sacrificed after 32 days and the spinal cords of the experimental groups were dissected out for the histopathologic and real time RT-PCR studies. Here, we showed that the clinical scores and infiltration of mononuclear cells of treated mice with IFN-β/LIF-hADSCs were decreased significantly. Remyelination and oligodendrogenesis were significantly increased in the test (IFN-β/LIF-hADSCs) group. The findings revealed that the pattern of inflammatory and anti- inflammatory cytokines gene expression in the IFN-β/LIF-hADSCs group was reversed comparing to control group. Overexpression of LIF as a neurotrophic and IFN-β as an anti-inflammatory cytokine in hADSCs increases the immunomodulatory effect of hADSCs and improves remyelination and oligodendrogenesis in EAE model. This, besides hADSCs capacity for proliferation and differentiation might enhance the treatment efficacy and provide a promising candidate for stem cell-based gene therapy of MS therapy in future.