bluuebunny/crossref_metadata_2025_split huggingface dataset:
Downregulated Dual-Specificity Protein Phosphatase 1 in Ovarian Carcinoma: A Comprehensive Study With Multiple Methods
Authors: Liang Zi-Qian , He Rong-Quan , Luo Jia-Yuan , Huang Zhi-Guang , Li Jie , Zhong Lu-Yang , Chen Jun-Hong , Huang Su-Ning , Shi Lin , Wei Kang-Lai , Zeng Jiang-Hui , Zeng Jing-Jing , Chen Gang 
Published: July 2022

Introduction: We aimed to explore the abnormal expression of dual-specificity protein phosphatase 1 (DUSP1) and its latent molecular mechanisms in ovarian carcinoma (OVCA).Materials and Methods: Two clinical cohorts collected from two different hospitals were used to evaluate the expression of DUSP1 protein in OVCA tissues. RNA-sequencing and microarray datasets were utilised to verify DUSP1 expression at mRNA levels in both OVCA tissues and in the peripheral blood of OVCA patients. Furthermore, an integrated calculation was performed to pool the standard mean difference (SMD) from each cohort in order to comprehensively assess the expression of DUSP1 in OVCA. Furthermore, we examined the relationship among DUSP1, tumour microenvironment (TME), and chemotherapy resistance in OVCA. Moreover, we used pathway enrichment analysis to explore the underlying mechanisms of DUSP1 in OVCA.Results: A pooled SMD of −1.19 (95% CI [−2.00, −0.38], p = 0.004) with 1,240 samples revealed that DUSP1 was downregulated in OVCA at both mRNA and protein levels. The area under the receiver operating characteristic curve of 0.9235 indicated the downregulated DUSP1 in peripheral blood may have a non-invasive diagnostic value in OVCA. Through six algorithms, we identified that DUSP1 may related to tumour-infiltrating T cells and cancer associated fibroblasts (CAFs) in OVCA. Pathway enrichment demonstrated that DUSP1 might participate in the mitogen-activated protein kinase (MAPK) signalling pathway. Furthermore, DUSP1 may have relations with chemotherapy resistance, and a favourable combining affinity was observed in the paclitaxel-DUSP1 docking model.Conclusion: DUSP1 was downregulated in OVCA, and this decreasing trend may affect the infiltration of CAFs. Finally, DUSP1 may have a targeting relation with paclitaxel and participate in MAPK signaling pathways.
Extending the radius of convergence for a class of Euler-Halley type methods
Authors: George Santhosh , Argyros Ioannis K 
Published: July 2022

The aim of this paper is to extend the radius of convergence and improve the ratio of convergence for a certain class of Euler-Halley type methods with one parameter in a Banach space. These improvements over earlier works are obtained using the same functions as before but more precise information on the location of the iterates. Special cases and examples are also presented in this study.
Motivasi Mahasiswa dalam Mengikuti Program Internship di Jepang
Authors: Muthiarawaty Muthiarawaty , Setiana Soni Mulyawan 
Published: July 2022

Abstract

This study aims to determine the motivation or interest of students in participating in the internship program in Japan. This research was conducted using a quantitative descriptive method. Data was collected by distributing questionnaires to active students of the Japanese language/literature study program from four universities in the city of Bandung. The results showed that most of the students had high motivation and interest in participating in the internship program in Japan. Internship programs that students want to participate in themselves, exist in various fields of work such as golf, restaurants, or hospitality. However, there are several factors that need to be considered by students when they want to join the internship program. So that students can take part in the internship program well, students need to be equipped with Japanese language skills that are equivalent to N3, so that later language will not be an obstacle and students can communicate and carry out their internship program smoothly and well. Therefore, the Study Program should hold special classes for students who are interested in participating in an internship program according to their field.

Keywords: Japanese department; motivation; student internship

Abstrak

Penelitian ini bertujuan untuk mengetahui motivasi atau minat mahasiswa dalam mengikuti program internship di negara Jepang. Penelitian ini dilakukan dengan menggunakan metode deskriptif kuantitatif. Pengumpulan data dilakukan dengan cara menyebarkan angket kepada mahasiswa aktif program studi bahasa/sastra Jepang dari empat Universitas di kota Bandung. Hasil penelitian menunjukkan bahwa sebagian besar mahasiswa memiliki motivasi dan minat yang tinggi untuk mengikuti program internship di Jepang. Program internship yang ingin diikuti oleh mahasiswa sendiri, ada dalam berbagai bidang pekerjaan seperti golf, restoran, ataupun perhotelan. Hanya saja, ada beberapa factor yang perlu diperhatikan oleh mahasiswa ketika ingin mengikuti program internship. Agar mahasiswa dapat mengikuti program internship dengan baik, mahasiswa perlu dibekali dengan kemampuan Bahasa Jepang yang setara dengan N3, sehingga nantinya Bahasa tidak menjadi kendala dan mahasiswa dapat berkomunikasi serta menjalani program internshipnya dengan lancar dan baik.. Oleh karena itu Program Studi sebaiknya mengadakan kelas khusus bagi mahasiswa yang tertarik mengikuti program internship sesuai bidangnya.

Kata Kunci: Departemen bahasa Jepang; magang mahasiswa; motivasi
The Antibacterial Activity Test Comparison of Green and Black Tea Ethanol Extract (Camellia sinensis) Against Propionibacterium acnes
Authors: Fahmi Aliyah , Sumaryati Syukur  , Zulkarnain Chaidir  , Sri Melia  
Published: July 2022

A study was conducted in connection with the comparison of antibacterial activity tests between ethanol extracts from green tea leaves and black tea leaves (Camellia sinensis) against Propionibacterium acnes. There were obtained by a softening technique that was softened for 24 hours. The filtrate was then concentrated to give a concentrated extract and evaporated ethanol content. The concentrated extract was then diluted with distilled water to extract 5%, 10%, and 15% concentration variations. The test method for inhibitory activity was the disc method using distilled water as a negative blank. The results obtained with blank, 5%, 10% and 15% green tea were 0. 5.25; 7.05 and 7.95 mm and black tea ethanol extract were 0; 2.50; 3.20 and 5.30 mm. The conclusion of this study is that the concentration of the extract is directly proportional to its inhibitory power, and the green tea ethanol extract is more potent than the black tea ethanol extract, so both can be used as antibacterial agents against P. acnes.
Thin-drift-layer n-channel 4H-SiC IGBT with low switching loss and switching ringing reduction
Authors: Watanabe Naoki , Yoshimoto Hiroyuki , Mori Yuki , Shima Akio 
Published: July 2022

Abstract
An n-channel 4H-SiC insulated-gate bipolar transistor (IGBT) with an extremely low switching loss was demonstrated by making 70 μm thin drift layers designed for 6.5 kV blocking voltage, without substrates. A conductivity-modulated bipolar operation was successfully performed as a on-voltage of 4.96 V at a 100 A cm−2 collector current. The turn-off losses under 3.6 kV/32 A operation were 8.8 (at room temperature) and 22.7 mJ (at 150 °C), which were much lower than the estimated losses of SiC IGBTs with thick drift layers. A detailed investigation on turn-off transition of SiC IGBTs specifically focused on a voltage-slope increase was also conducted. This phenomenon can cause ringing in switching characteristics. A device structure has been proposed to eliminate it by controlling the expansion of a depletion layer. Voltage-slope control and ringing reduction without noticeable degradation in static characteristics and switching loss were demonstrated with the SiC IGBT with the proposed device structure.
Importance of source and drain extension design in cryogenic MOSFET operation: causes of unexpected threshold voltage increases
Authors: Inaba Takumi , Asai Hidehiro , Hattori Junichi , Fukuda Koichi , Oka Hiroshi , Mori Takahiro 
Published: July 2022

Abstract
Increased threshold voltages have been observed during linear-mode operation of short-channel bulk metal-oxide-semiconductor field-effect transistors (MOSFETs) employing shallow source and drain extension technology at cryogenic temperatures. These increases were suppressed during saturation-mode operation, which resulted in the increase of a threshold voltage variation between linear- and saturation-modes as if drain-induced barrier lowering occurred. Numerical simulations revealed that these increases originate from enhanced depletion in the extension region and subsequent increases in channel resistance at cryogenic temperatures. These data suggest that shallow extensions should be designed more carefully in the case of MOSFETs intended for cryogenic operation.
Sistem Informasi Geografis Kerajinan Desa Kamasan Berbasis Website Dengan Framework Codeigniter
Authors: Atmaja I Gede Khrisna Okta , Wijaya I Nyoman Yudi Anggara , Juliharta I Gede Putu Krisna 
Published: July 2022

<p><strong><em>Abstrak. </em></strong>Makalah ini menyajikan model Sistem Informasi Geografis pengerajin di desa Kamasan berbasis web, yang diharapkan dapat membantu orang-orang yang belum memahami lukisan desa kamasan, terutama wisatawan mancanegara dan domestik yang berminat mengetahui sejarah Uang Bolong dan lukisan desa kamasan. Pengembangan sistem mengikuti tahapan-tahapan dalam metode <em>Waterfall</em>, dengan memanfaatkan berbagai data dan informasi yang diperoleh dari wawancara dengan responden di lokasi pengerajin, yaitu terhadap 5 orang pelaku pengerajin dan 20 orang wisatawan lokal dan mancanegara. Pengembangan sistem menggunakan bahasa pemograman PHP dengan bantuan <em>framework CodeIgniter</em> dan MySQL sebagai databasenya, sedangkan pengujian menggunakan metode pengujian <em>Blackbox</em> untuk memastikan fitur-fitur fungsional perangkat lunak telah berfungsi dengan benar sesuai hasil kajian kebutuhan. Hasil uji fungsional menunjukkan bahwa fitur-fitur pada Sistem Informasi Geografis yang dikembangkan, dapat menginformasikan keberadaan para pembuat kerajinan di desa Kamasan.</p><p><strong>Kata kunci: </strong>Sistem Informasi Geografis, Berbasis Web, <em>framework CodeIgniter</em>, Desa Wisata</p><p> </p><p><em>Abstrac. </em><em>This paper presents a web-based model of the Geographical Information System of craftsmen in Kamasan village, which is expected to help people who do not understand the paintings of Kamasan villages, especially foreign and domestic tourists who are interested in knowing the history of “Uang Bolong” and Kamasan village paintings. Development system follows the stages in the Waterfall method, by utilizing various data and information obtained from interviews with respondents at the craftsman location, namely to 5 craftsmen and 20 local and foreign tourists. The development of the system uses the PHP programming language with the help of the CodeIgniter and MySQL framework as the database, while testing uses the Blackbox testing method to ensure the functional features of the software are functioning properly according to the results of the needs assessment. Functional test results show that the features in the developed Geographic Information System can inform the existence of craft makers in the Kamasan village.</em></p><p><strong><em>Keywords:</em></strong><em> Geographic Information Systems, Web-Based, CodeIgniter framework, Tourist Village</em></p>
Analisa Valuasi Startup Menggunakan Metode The Dave Berkus Untuk Menentukan Nilai Perusahaan PT. Farmindo
Authors: Widhiantari Ni Putu Juli , Swastika I Putu Agus , Estiyanti Ni Made 
Published: July 2022

<p>Abstrak. PT. Farmindo Teknologi Nusantara dengan produk “PONKOD” Alat Bantu Panjat Kelapa adalah tenant dari Inkubator BisnisTeknologi tahun 2017 yang bergerak dalam bidang telnologi pertanian yaitu sebuah produk peralatan untuk membantu petani kelapa untuk memanen/memetik buah kelapan dengan mudah dan aman. Dengan “PONKOD” Alat Bantu Panjat Kelapa, kini siapa saja memanjat dengan mudah. Nilai valuasi perusahaan tentunya akan menjadi daya tarik bagi para investor untuk menanamkan modal pada perusahaan PT. Farmindo Teknologi Nusantara. Untuk menghitung nilai valuasi startup harus mengetahui faktor-faktor non keuangan yang mempengaruhi nilai dari perusahaan dengan menghitung secara kualitatif dan kuantitatif nilai perusahaan menggunakan Metode The Dave Berkus. Metode The Dave Berkus, yaitu metode untuk menilai kualitas atau karakteristik yang terpenting dari perusahaan Startup dan mengharuskan investor untuk memperkirakan secara subjektif kontribusi nilai (elemen) yang ada pada perusahaan secara kualitatif dan kuantitatif, sehingga dari rentang nilai dari The Dave Berkus akan di jumlahkan sehingga mendapatkan hasil pra-pendapatan dari perusahaan.</p><p class="Default"><strong><em>Kata kunci: Valuasi Startup, Metode The Dave Berkus, Nilai Perusahaan</em></strong></p><p class="Default"><em> </em></p><p><strong><em>Abstrack. </em></strong><em>PT. Farmindo Teknologi Nusantara with product "PONKOD" coconut climbing tools is a tenant of business incubator technology year 2017 which is engaged in the field of agricultural telnology is a product of equipment to help coconut farmers to harvest/pick the fruit of the eighth easily and safely. With "PONKOD" coconut climbing aids, now anyone climbs easily.</em><em> </em><em>The valuation value of the company will certainly be an attraction for investors to invest in the company PT. Farmindo Teknologi Nusantara. To calculate the value of the startup valuation should be aware of the non financial factors affecting the value of the company by qualitative and quantitative calculating The value of The company using The Dave Berkus method. The Dave Berkus method, which is the method to assess the quality or characteristics of the company's Startup and require investors to estimate the value of contributions (elements) that exist in the company qualitatively and Quantitative, so from The value range of The Dave Berkus will be aggregated so as to get pre-revenue results from The company.</em></p><p><strong><em>Keywords: Startup Valuation, The Dave Berkus Method, Company Value</em></strong></p>
Penilaian Tingkat Keamanan Teknologi Informasi Menggunakan Metode Keamanan Informasi (KAMI) Dan Vulnerability Assessment
Authors: Atmaja Dewa Gede Anom , Krisna Juliharta I Gede Putu , Fredlina Ketut Queena 
Published: July 2022

<p><strong><em>Abstrak. </em></strong>Diskominfostatistik atau Dinas Komunikasi, Informatika, dan Statistik Kota Denpasar merupakan intansi pemerintah yang bergerak sebagai pengawas dan penerapan TIK di wilayah Kota Denpasar dalam menangani permasalahan teknologi informasi dan sistem informasi yang dimiliki. Semua kegiatan teknologi informasi dan sistem informasi dipusatkan dan dikembangkan di Dinas Komunikasi, Informatika, dan Statistik Kota Denpasar. Dalam hal ini pemerintah berperan penting dalam meningkatkan mutu kualitas yang ada sesuai prosedur standarisasi keamanan yang layak. Paper ini menganalisis tingkat keamanan Teknologi Informasi menggunakan kombinasi Metode Keamanan Informasi dan <em>Vulnerability Assessment, </em>studi kasus pada<em> </em>Dinas Komunikasi, Informatika, dan Statistik Kota Denpasar. Hasil analisis tingkat kesiapan menunjukkan dari 5 mesin yang melingkupi E-Pajak, AkuWaras, Aplikasi, Eproc, dan Bursakerja terdapat 1 level critical, 10 level high, 24 level medium dan 16 level low.</p><p><strong>Kata Kunci</strong><strong>:</strong><em> Keamanan Teknologi Informasi, Metode Vulnerability Assessment, Metode Kemanan Informasi</em></p><p><strong><em> </em></strong></p><p><strong><em>Abstract. "</em></strong><em>Diskominfostatistik" of Denpasar City is a government agency that operates as a supervisor and application of ICT in the Denpasar City area in dealing with problems of information technology and information systems owned. All information technology and information system activities are centralized and developed at the Denpasar City Office of Communication, Informatics and Statistics. In this case, the government plays an important role in improving the quality of existing quality according to proper safety standardization procedures. This paper analyzes the security level of Information Technology using a combination of Information Security Methods and Vulnerability Assessment, a case study at the Denpasar City Office of Communication, Informatics, and Statistics. The results of the readiness level analysis show that of the 5 machines covering E-Tax, AkuWaras, Applications, Eproc, and Bursakerja, there are 1 critical level, 10 high levels, 24 medium levels and 16 low levels.</em></p><p><strong><em>Keywords</em></strong><em>: Information Technology Security, Vulnerability Assessment Method, Information Security Method</em></p>
Pengembangan Sistem Penjualan Dengan Metode Waterfall Pada Toko UD.Vijaya Laksmi Badung
Authors: Kusuma Imas , Werthi Komang Tri , Anggara I Nyoman Yudi 
Published: July 2022

<p>Abstrak. UD. Vijaya Laksmi merupakan salah satu perusahaan dagang yang bergerak dalam bidang penjualan batu alam. Selama ini proses penjualan dilaksanakan secara manual, masalah yang muncul akibat dari proses secara manual yaitu hilangnya data, rentan terjadinya kesalahan pada pencatatan, lambatnya proses penjualan, dan lambatnya pelaporan penjualan kepada pihak manajemen. Tujuan dari penelitian ini adalah mengembangkan sistem penjualan pada UD. Vijaya Laksmi, untuk dapat membantu perusahaan dalam menyediakan, pengelolaan data penjualan serta membantu dalam pelaporan transaksi penjualan dengan cepat dan terkomputerisasi kepada pihak manajemen. Sistem informasi penjualan memudahkan perusahaan dalam proses bisnisnya yang menghasilkan mutu informasi yang lebih baik dan meminimalisir terjadinya kesalahan-kesalahan yang terjadi jika menggunakan sistem manual dalam menjalankan fungsinya. Perancangan sistem informasi penjualan dilakukan dengan berbasis website menggunakan framework codeigniter dengan bahasa pemrograman PHP (Hypertext Preprocessor) dan disimpan menggunakan database MysQL. Dalam pengumpulan data peneliti menggunakan metode pengamatan, wawancara, dan kajian pustaka. Sedangkan dalam pengembangan sistem peneliti menggunakan metode waterfall. Penilitian dilakukan hingga tahap implementasi dan pengujian sistem, pengujian sistem dilakukan dengan black box testing. Kata kunci: Sistem Informasi Penjualan, Framework Codeigniter, PHP (Hypertext Preprocessor), MySQL, Metode Waterfall, Black Box Testing.</p><p><br /> Abstract. UD. Vijaya Laksmi is a trading company engaged in the sale of natural stone. During this time the sales process is carried out manually, problems that arise as a result of the process manually are loss of data, susceptibility to recording errors, slow sales process, and slow sales reporting to management. The purpose of this research is to develop a sales system at UD. Vijaya Laksmi, to be able to assist companies in providing, managing sales data and assisting in reporting sales and purchase transactions quickly and computerized to management. Sales information systems facilitate companies in their business processes that produce better quality information and minimize the errors that occur when using a manual system in carrying out its functions. The design of the sales information system is done on a website-based basis using a codeigniter framework with the PHP (Hypertext Preprocessor) programming language and stored using the MysQL database. In collecting data researchers used the method of observation, interviews, and literature review. While in the development of systems researchers used the waterfall method. The research was carried out until the implementation and testing stages of the system, system testing was carried out with black box testing. Keywords: Development Sales Information System, Framework Codeigniter, PHP (Hypertext Preprocessor) MysQL, Waterfall Method, Black Box Testing.</p>
Penerapan Multimedia Development Life Cycle dalam Pengembangan Media Visualisasi Pembelajaran Interaktif
Authors: Maulana Agung , Kusdinar Asep Budiman , Sunarto Asril Adi 
Published: July 2022

<p>ABSTRAK. Pada umumnya sistem pembejaran di Perguruan Tinggi saat ini menggunakan media pembelajaran visual yang disalurkan melalui proyektor, sehingga masih kurang efektif untuk memvisualisasikan materi perkuliahan bagi mahasiswa. Di sisi lain, perkembangan Teknologi Informasi memungkinkan penggunaan Multimedia interaktif yang dilengkapi dengan alat pengontrol yang dapat dioperasikan oleh pengguna, sehingga pengguna dapat mengendalikan sistem pembelajaran secara efektif. Paper ini menyajikan konsep penerapan multimedia development life cycle pada aplikasi media pembelajaran interaktif. Metode pengembangan media pembelajaran berbasis Multimedia development life cycle melalui Enam tahap meliputi: konsep, perancangan, pengumpulan materi, pembuatan, pengujian dan distribusi. Hasil uji program melalui uji Blackbox menunjukkan fitur-fitur fungsionalitas telah sesuai dengan kebutuhan pengguna. Kata kunci: Media pembelajaran, Multimedia interaktif, Multimedia development life cycle <br /> <br />ABSTRACT. In general, the current education system in tertiary institutions uses visual learning media that is channeled through a projector, so it is still ineffective in visualizing lecture material for students. On the other hand, the development of Information Technology allows the use of interactive multimedia which is equipped with a controller that can be operated by the user, so that the user can control the learning system effectively. This paper presents the concept of implementing the multimedia development life cycle in interactive learning media applications. Multimedia development life cycle based on learning media development methods through six stages including: concept, design, material gathering, manufacture, testing and distribution. The test results of the program through the Blackbox test show that the functionality features are in accordance with user needs. Keywords: Learning media, Interactive multimedia, Multimedia development life cycle</p>
Model Sistem Pakar Untuk Mendiagnosa Kerusakan pada Mesin Motor Karburator Dengan Metode Forward Chaining
Authors: Saputra Alfi Maulana , Indrayana Didik , Kusdinar Asep Budiman 
Published: July 2022

<p>Abstrak. Banyak pengguna sepeda motor jenis karburator yang tidak memiliki pengetahuan mengenai kerusakan pada mesin sepeda motor berjenis karburator, sehingga pengguna sepeda motor harus membawanya ke bengkel sepeda motor untuk perawatan. Permasalahan kemudian terjadi ketika sedang tidak berada pada bengkel terdekat, sehingga perlu penangan darurat secara mandiri. Paper ini mengembangkan sebuah model Sistem Pakar yang dapat digunakan untuk mengadopsi pengetahuan seorang montir sepeda motor ke komputer agar komputer dapat memberikan petunjuk dalam menyelesaikan masalah pada kerusakan motor karburator. Sistem menggunakan penalaran berbasis Forward Chaining dalam mendiagnosa kerusakan. Rancangan Sistem yang dikembangkan menyediakan fitur Basis Pengetahuan untuk mendiagnosa kerusakan pada mesin motor berjenis karburator, dan dapat digunakan secara online, sehingga diharapkan dapat diakses kapan saja dan dimana saja. Kata kunci: Sistem Pakar, Runut Maju, Motor Jenis Karburator <br /> <br />Abstract. Many carburetor type motorcycle users do not have knowledge of damage to carburetor-type motorcycle engines, so motorcycle users have to take them to a motorcycle repair shop for maintenance. The problem then occurs when he is not at the nearest workshop, so he needs emergency handlers independently. This paper develops an Expert System model that can be used to adopt the knowledge of a motorcycle mechanic into a computer so that the computer can provide instructions in solving problems with carburetor motor failure. The system uses Forward Chaining-based reasoning in diagnosing damage. The developed system design provides a Knowledge Base feature to diagnose carburetor-type engine malfunctions, and can be used online, so it is hoped that it can be accessed anytime and anywhere. Keywords: Expert System, Forward Trace, Motor Carburetor Type</p>