bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Different Polishing Systems on Surface Roughness and Crystal Structure of Zirconia
Authors: Chen Cheng , Zeng Xiaohua 
Published: May 2022

Objective. Intraoral polishing systems have become an alternative method for reglazing, which is important to prevent or minimize rapid wear of the opposing teeth. To assess the influence of different polishing systems and duration on surface roughness and crystal structure of zirconia was compared, contributing to the preparation and effect improvement of clinical zirconia restorations. Methods. Forty-eight zirconia specimens with equal size were fabricated by cutting and sintering zirconia discs. Then X-ray diffractometer (XRD) was adopted for examination of the specimens. Six specimens were selected as the grinding-polishing group (GL) after polishing, grinding, and glazing. Then six specimens were randomly selected from the remaining specimens as the grinding-unpolished group (GR) after surface conditioning by dental diamond burs. Subsequently, based on different polishing systems and duration, the rest of specimens were divided into following groups (

n
=
6

): Youdent-20s group (Y20), Youdent-40s group (Y40), Youdent-60s group (Y60), Toboom-20s group (T20), Toboom-40s group (T40), and Toboom-60s group (T60). Additionally, a contour graph was applied for assessing the surface roughness of zirconia, scanning electron microscope (SEM) for observing surface topography, and X-ray diffraction analysis (XRD) for determining crystal structure of zirconia. Results. The GR group had the highest roughness, and the roughness of the specimens polished for 20 s with different polishing systems was significantly higher than those polished for 40 s and 60 s with the same polishing systems. There were no significant difference between the Y20 and T20 groups, while the roughness of the specimens in both Y40 and Y60 groups was significantly higher than that of the T40 and T60 groups. And with the increasing polishing duration, the surface morphology of the specimen was gradually smooth and the morphology was gradually regular. Besides, the surface scratches of the T group were shallower than that of the Y group at the same polishing duration. The peak value of XRD profile of the specimen after grinding and polishing process was consistent with the baseline pattern of that the original specimen. Conclusion. Glazing can reduce the surface roughness of the specimens. Besides, the polishing effect of Toboom (TOB) system (

polishing

duration
=
60

s

) is the best. And different polishing durations of TOB system have no significant effect on the crystal surface structure of the specimen.
Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner
Authors: Wu Jinghai , Liu Xin , Reeser Julie A. Wallace , Trimboli Anthony J. , Pécot Thierry , Sizemore Gina M. , Naidu Shan K. , Fernandez Soledad A. , Yu Lianbo , Hallett Michael , Park Morag , Leone Gustavo W. , Hildreth Blake E. , Ostrowski Michael C. 
Published: May 2022

Abstract

Coevolution of tumor cells and adjacent stromal elements is a key feature during tumor progression; however, the precise regulatory mechanisms during this process remain unknown. Here, we show stromal p53 loss enhances oncogenic KrasG12D, but not ErbB2, driven tumorigenesis in murine mammary epithelia. Stroma-specific p53 deletion increases both epithelial and fibroblast proliferation in mammary glands bearing the KrasG12D oncogene in epithelia, while concurrently increasing DNA damage and/or DNA replication stress and decreasing apoptosis in the tumor cells proper. Normal epithelia was not affected by stromal p53 deletion. Tumors with p53-null stroma had a significant decrease in total, cytotoxic, and regulatory T cells; however, there was a significant increase in myeloid-derived suppressor cells, total macrophages, and M2-polarized tumor-associated macrophages, with no impact on angiogenesis or connective tissue deposition. Stroma-specific p53 deletion reprogrammed gene expression in both fibroblasts and adjacent epithelium, with p53 targets and chemokine receptors/chemokine signaling pathways in fibroblasts and DNA replication, DNA damage repair, and apoptosis in epithelia being the most significantly impacted biological processes. A gene cluster in p53-deficient mouse fibroblasts was negatively associated with patient survival when compared with two independent datasets. In summary, stroma-specific p53 loss promotes mammary tumorigenesis in an oncogene-specific manner, influences the tumor immune landscape, and ultimately impacts patient survival.

Implications:
Expression of the p53 tumor suppressor in breast cancer tumor stroma regulates tumorigenesis in an oncogene-specific manner, influences the tumor immune landscape, and ultimately impacts patient survival.
Combined Oral Triglyceride and Glucose Tolerance Test After Acute Ischemic Stroke to Predict Recurrent Vascular Events: The Berlin “Cream&Sugar” Study
Authors: Nave Alexander H. , Kaynak Nurcennet , Mai Knut , Siegerink Bob , Laufs Ulrich , Heuschmann Peter U. , Liman Thomas G. , Ebinger Martin , Endres Matthias 
Published: May 2022

Background:
Elevated triglyceride and glucose levels are associated with an increased cardiovascular disease risk including ischemic stroke. It is not known whether the response to a combined oral triglyceride and glucose challenge after ischemic stroke improves identification of patients with increased risk for recurrent vascular events.

Methods:

The prospective, observational Berlin “Cream&Sugar” study was conducted at 3 different university hospital sites of the Charité–Universitätsmedizin Berlin, Germany, between January 24, 2009 and July 31, 2017. Patients with first-ever ischemic stroke were recruited 3 to 7 days after stroke. An oral triglyceride tolerance test (OTTT) and consecutive blood tests before (t
0
) as well as 3 (t
1
), 4 (t
2
), and 5 hours (t
3
) after OTTT were performed in fasting patients. An oral glucose tolerance test was performed in all nondiabetic patients 3 hours after the start of OTTT. Outcomes of the study were recurrent fatal or nonfatal stroke as well as a composite vascular end point including stroke, transient ischemic attack, myocardial infarction, coronary revascularization, and cardiovascular death assessed 1 year after stroke. Cox regression models were used to estimate hazard ratios and corresponding 95% CIs between patients with high versus low levels of triglyceride and glucose levels.

Results:

Overall 755 patients were included; 523 patients completed OTTT and 1-year follow-up. Patients were largely minor strokes patients with a median National Institutes of Health Stroke Scale score of 1 (0–3). Comparing highest versus lowest quartiles of triglyceride levels, neither fasting (adjusted hazard ratio
t0
, 1.24 [95% CI, 0.45–3.42]) nor postprandial triglyceride levels (adjusted hazard ratio
t3
, 0.44 [95% CI, 0.16–1.25]) were associated with recurrent stroke. With regard to recurrent vascular events, results were similar for fasting triglycerides (adjusted hazard ratio
t0
, 1.09 [95% CI, 0.49–2.43]), however, higher postprandial triglyceride levels were significantly associated with a lower risk for recurrent vascular events (adjusted hazard ratio
t3
, 0.42 [95% CI, 0.18–0.95]). No associations were observed between fasting and post–oral glucose tolerance test blood glucose levels and recurrent vascular risk. All findings were irrespective of the diabetic status of patients.

Conclusions:
In this cohort of patients with first-ever‚ minor ischemic stroke, fasting triglyceride or glucose levels were not associated with recurrent stroke at one year after stroke. However, higher postprandial triglyceride levels were associated with a lower risk of recurrent vascular events which requires further validation in future studies. Overall, our results do not support the routine use of a combined OTTT/oral glucose tolerance test to improve risk prediction for recurrent stroke.
Optimizing Spatial Quality Control for a Dense Network of Meteorological Stations
Authors: Alerskans Emy , Lussana Cristian , Nipen Thomas N. , Seierstad Ivar A. 
Published: May 2022

Abstract
Crowdsourced meteorological observations are becoming more prevalent and in some countries their spatial resolution already far exceeds that of traditional networks. However, due to the larger uncertainty associated with these observations, quality control (QC) is an essential step. Spatial QC methods are especially well suited for such dense networks since they utilize information from nearby stations. The performance of such methods usually depends on the choice of their parameters. There is, however, currently no specific procedure on how to choose the optimal settings of such spatial QC methods. In this study we present a framework for tuning a spatial QC method for a dense network of meteorological observations. The method uses artificial errors in order to perturb the observations to simulate the effect of having errors. A cost function, based on the hit and false alarm rate, for optimizing the spatial QC method is introduced. The parameters of the spatial QC method are then tuned such that the cost function is optimized. The application of the framework to the tuning of a spatial QC method for a dense network of crowdsourced observations in Denmark is presented. Our findings show that the optimal settings vary with the error magnitude, time of day, and station density. Furthermore, we show that when the station network is sparse, a better performance of the spatial QC method can be obtained by including crowdsourced observations from another denser network.
A Modeling Study of Typhoon Lekima (2019) with the Topographic Influence of Taiwan
Authors: Huang Ching-Yuang , Sha Sheng-Hao , Kuo Hung-Chi 
Published: May 2022

Abstract
The global model FV3GFS is used to simulate Typhoon Lekima (2019), which exhibited track deflection when approaching west-northwestward toward Taiwan. The model successfully simulates the observed northward deflection and the track deflection is produced by topographically induced wavenumber-1 flow with a pair of vorticity gyres around the typhoon center. The gyres tend to rotate counterclockwise about the typhoon center and thus induce an earlier northward and then westward movement. Azimuthal-mean kinetic energy budget of the typhoon indicates that the effect of Taiwan terrain modifies the correlation between the recirculating flow and pressure gradient force east of Taiwan, leading to a slight weakening of the typhoon during the later track deflection. The northward cyclonic deflection in general will be induced for a cyclone to move toward the central to northern terrain such as Lekima. The curvature of the northward cyclonic deflection, however, is large (small) for a northwestbound (nearly westbound) vortex depending on the track-topography-impinging angle. The curvature difference can be explained with the concept of recirculating flow, which is the flow splitting due to topography and rejoins the vortex to produce the wavenumber-1 asymmetry. The cyclonic track curvature of the northwestbound Lekima is larger than that of the westbound Maria (2018) in the FV3GFS simulations. This adds robustness to the conclusion that minor to moderate terrain-related track deflections can be well simulated by the FV3GFS global model near Taiwan.
The Characterization and Outcomes of Colorectal Malignancy in Patients ≤40 Years of Age: A Single-Center Experience
Authors: Melendez-Rosado Jose , Castaneda Daniel , Strassmann Victor , Altinel Yuksel , Ioannidis Argyrios , Rhode Sara , Da Silva Giovanna , Wexner Steven D. , Lopez Rocio , Jimenez Brenda 
Published: May 2022

Background Implementation of screening modalities has led to a decreased incidence of colorectal malignancies. Unfortunately, overall incidence has remained unchanged as cases have increased in patients below the suggested screening age. Therefore, we evaluated characteristics and oncological outcomes of malignancies in patients ≤40 years of age. Methods Single-center retrospective analysis of prospectively collected data of malignancies in patients ≤40 years evaluated in our institution between 2010 and 2016. Basic descriptors for demographic, clinical, histologic, and genetic data were collected. Disease-free survival (DFS) and 5-year overall survival (OS) were compared for patients between 30-40 years and <30 years. Results Fifty-six patients ≤40 years were identified, 44 of whom (96.5%) had adenocarcinomas. Most common malignancy location was the rectum (64.3%). Despite aggressive tumor characteristics such as moderate/poor differentiation (88.6%), lymphovascular invasion (26.8%), perineural invasion (21.4%), and advanced tumor stage T3/T4 (60.7%), OS rate was 94.6%. Both age groups had similar oncologic characteristics. There was a trend toward worse OS (2/11 and 1/45, P = .06) but not for DFS (7/11 and 15/43, P = .18) in patients <30 years of age compared to 30-40 years. There were no differences in OS (3/44 vs 0/88, P = .44) or DFS (17/42 vs 3/8, P = .80) between sporadic vs non-sporadic malignancies, respectively. Conclusions Patients ≤40 years of age with malignancy have advanced tumor stages and aggressive tumor characteristics at diagnosis. Although there is higher OS risk for patients <30 compared to those aged 30-40 years, no differences were found for DFS between these two groups.
Effect of stacking sequence of glass and jute fiber reinforced polymer composites on their low velocity impact properties
Authors: Pandian Amuthakkannan , Hameed Sultan Mohamed Thariq , Manikandan Vairavan , Marimuthu Uthayakumar , Kanagaraj Arun Prasath , Khan Tabrej 
Published: May 2022

This paper investigated the effect of stacking sequence on the low velocity impact behavior of glass and jute fiber reinforced hybrid composites. The hand layup method is used to fabricate the composites with various stacking sequences. The low velocity impact analysis was carried out at various impact energies, namely 5 J, 10 J and 15 J. Dye penetrant inspection (liquid penetrate inspection) was performed to analyses the damage area in the composites. Compression after impact (CAI) testing was conducted to study the compression strength of the composites after the impact. The study revealed that the jute fiber composites exhibited better results in terms of energy absorption, but the damage area of the composites was higher, compared to the other specimens fabricated. Meanwhile, hybrid composite S7 presented high energy absorption and the minimum damage area. To conclude, the hybrid composite S7 appeared to have the optimum formulation, showing better results in energy absorption, with lower damage and higher compression strength.
How Bereaved Parents Experience Public, Self Stigma Years After a Child’s Death
Authors: Heo So Jung , Kim Young Ae , Lee Dong Hun , Shin Ji Young 
Published: May 2022

This study identifies the stigma experienced by 12 bereaved parents 2 and 5 years after losing a child in the Sewol ferry disaster in South Korea. Using thematic analysis, we categorized the experience of stigma into two components based on Corrigan and Kosyluk’s social cognitive model of stigma: public stigma and self-stigma, and each was analyzed into three types of stigma: stereotype, prejudice, and discrimination. We identified four additional factors related to stigma mitigation. The potential implications for characterizing the experiences of bereaved parents, particularly those facing stigma, are discussed in light of these findings in the longitudinal perspective.
Factor Structure of the Telugu Version of the COVID-19 Pandemic-Related Perceived Stress Scale (PSS-10-C) Administered on Grassroots Frontline Health Care Workers of Rural Telangana
Authors: Tikka Sai Krishna , Malathesh Barikar C , Bhatia Vikas , Sahoo Durgesh Prasad , Sreepada Nuthan , Meena Suraj Kumar 
Published: May 2022

Background: During the COVID-19 pandemic, perceived stress is an important determinant of mental health problems, especially in health care workers (HCW). By and large, regional language tools to assess perceived stress in the context of the pandemic have not been validated in India. We aim to explore the factor structure of the Telugu translated version of the COVID-19 pandemic-related Perceived Stress Scale (PSS-10-C) administered on grassroots frontline HCW of rural Telangana, India. Methods: Data relating to 311 grassroots frontline HCW consisting of accredited social health activists (ASHA), multipurpose health workers (MPHW), and auxiliary nurse and midwives (ANMs) working in rural primary health centers (PHC) in five districts of Telangana were analyzed. An exploratory factor analysis was conducted to identify latent factors. Convergent validity was assessed by computing Pearson product-moment correlations between the scores of PSS-10-C and Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) scales. Results: The principal component analysis showed that the 10 items of the scale were significantly loaded by two latent factors with eigen values of 2.792 and 2.009, respectively. Factor solution showed that six and four items correlated with each of the two factors, respectively. Significant correlations between PSS-10-C, GAD-7, and PHQ-9 scores showed convergent validity. The two factors may represent substantive factors “perceived self-efficacy” and “perceived helplessness.” There may be an influence of the reverse-coded method on the factor solution. Conclusion: The Telugu translated version of PSS-10-C holds fair-to-good psychometric properties.
Teen Addiction Severity Index (T-ASI): Hindi Translation and Validation for Use in India
Authors: Sharma Renu , Dhawan Anju , Kaminer Yifarh , Chopra Anita 
Published: May 2022

Background: Substance use among adolescents is increasing rapidly and becoming a global health concern worldwide. Because of the changing trends and rising magnitude in India, there is an urgent need to adapt and validate instruments to assess adolescents’ substance use. The study translated the Teen-Addiction Severity Index (T-ASI) into Hindi and assessed the psychometric properties. Methods: The instrument (T-ASI) was translated from English to Hindi using: (a) forward translation: translation from the source language into the target one, (b) comparison and synthesis of the two translated versions, (c) blind backward translation, (d) comparison of the two back-translated versions and development of prefinal version, (e) conceptual evaluation of items and pilot study, and (f) assessing the psychometric properties. Results: The content validity of Hindi T-ASI was quite high (0.97). A significant positive correlation r = 0.439* (0.014) between the T-ASI family functioning domain and the organization scale of the Family Environment Scale (FES) demonstrated good concurrent validity. Youth self-report substance use domain correlated well with youth self-report behavior problems scale r = 0.385 (0.033) and the psychiatric status domain correlated with all three internalizing 0.606 (<0.001), externalizing 0.363 (0.045), and behavior problem scale 0.546** (0.001). Construct validity showed significant differences between two groups (substance-using and nonsubstance-using groups) in all domains except school and peer status. Cross-cultural validity shows that the two versions are equivalent. The translated version showed satisfactory reliability (Cronbach’s α = 0.727). Conclusion: The translation and validation of Hindi–T-ASI show adequate psychometric properties and can be recommended for use in treatment settings across the country.
The Extent of Endorsement of Distal to Proximal Dysfunctional Cognitions in Individuals with Alcohol Dependence: A Comparative Cross-Sectional Study in the Indian Context
Authors: Singh Geeta , Kaloiya Gauri Shanker , Dhawan Anju , Balhara Yatan Pal Singh , Mishra Ashwani Kumar 
Published: May 2022

Background: Dysfunctional basic cognitions have been suggested as potential vulnerability markers for alcohol dependence (AD). Although there is a growing body of research on the role of distal cognitive vulnerability factors such as early maladaptive schema in the development of AD, little is known about the role of proximal cognitive factors such as cognitive distortions, dysfunctional attitude, and negative automatic thoughts. Methods: This comparative cross-sectional study aimed to examine dysfunctional cognitions in individuals with AD ( n = 84) in comparison with healthy individuals ( n = 60). The dysfunctional cognitions were assessed on the Young Schema Questionnaire third version of Short Form, Cognitive Distortion Scale, Dysfunctional Attitude Scale-Form A, and Automatic Thought Questionnaire. Multivariate analysis of covariance was conducted to analyze the group differences in dysfunctional cognitions. Results: After controlling for the group difference in employment status, 12 of 18 schemas were more prevalent in individuals with AD than in healthy individuals. Individuals with AD also scored higher on seven of 10 cognitive distortions, as well as in terms of dysfunctional attitude and negative automatic thoughts. Conclusion: Dysfunctional cognition may play a significant role in developing AD. The findings may enhance our understanding of the nature and severity of dysfunctional cognitions in the development of AD. The information may further assist the clinicians in implementing adequate intervention strategies to manage dysfunctional cognitions in individuals with AD.
Investigating the benefits and harms of hypodermoclysis of patients in palliative care: A consecutive cohort study
Authors: Agar Meera R , Chang Sungwon , Amgarth-Duff Ingrid , Garcia Maja V , Hunt Jane , Phillips Jane L , Sinnarajah Aynharan , Fainsinger Robin 
Published: May 2022

Background: Palliative populations are at risk for dehydration which can cause discomfort, distress and cognitive symptoms. Subcutaneous hydration (‘hypodermoclysis’) has been used as an alternative administration route to the more invasive intravenous route, but research is lacking on its net clinical effects (harms and benefits) for palliative populations, particularly in real world settings. Aim: To quantify prospectively the net clinical effects of hypodermoclysis in palliative patients with advanced disease who required supplementary fluids. Design: Multisite, multinational consecutive cohort study. Setting/participants: Patients receiving hypodermoclysis in an inpatient palliative care setting. Results: Twenty sites contributed data for 99 patients, of which 88 had complete benefits and harms data. The most common primary target symptom for infusion was generalised weakness (18.2%), and the most common non-symptom indication was supplemental hydration (31.8%). Benefits were experienced in 33% of patients in their primary target symptom, and in any symptom in 56.8%. Harms were experienced in 38.7% of patients (42% at Grade 1). Benefits increased with higher performance status, while harms were more frequent in patients with lower performance status (Australia-modified Karnofsky performance status ⩽40). Patients in the terminal phase of their illness experienced the least benefit (15.4% in any indication only) and had more frequent harms (38%). Conclusions: Hypodermoclysis may improve certain symptoms in patients in palliative care but frequency of harms and benefits may differ at certain timepoints in the illness trajectory. Further research is needed to better delineate which patients will derive the most net clinical benefit from hypodermoclysis.