bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a preoperative prediction model based on spectral CT to evaluate axillary nodal burden in patients with early-stage breast cancer
Authors: Zeng Fang , Cai Weifeng , Lin Lin , Chen Yilin , Chen Lili , Li Jing , Wang Xinrong , Wang Chuang , Xue Yunjing 
Published: July 2022

Abstract
Background Axillary lymph node (ALN) status is an important factor affecting the surgery planning. We developed a new prediction model based on spectral CT to evaluate the axillary nodal burden in patients with early-stage breast cancer.Methods A total of 146 early-stage breast cancer patients with pathologically confirmed axillary lymph node (ALN) status who underwent spectral CT scans were retrospectively enrolled and stratified sampling to categorize into a training cohort (n = 102) and validation cohort (n = 44). These patients were classified into low (stage pN0 or pN0[i+] or pN1mi) and high (stage pN1–3) axial nodal burden subgroups. The morphologic criteria and quantitative spectral CT parameters of the most suspicious lymph node were measured and compared between high axillary lymph node (HANB) and low axillary lymph node (LANB). Univariate analyses were performed to identify the association between factors and HANB. Least absolute shrinkage and selection operator (Lasso) was used to further screen predictive indicators to build a logistic model. The receiver operating characteristic (ROC) curve and decision curve analysis (DCA) were used to evaluate the models.Results Univariate analysis demonstrated that 16 risk factors were associated with HANB (P < 0.05). For arterial phase, the LASSO regression analysis identified the 5 most powerful factors (the longest-to-shortest diameter ratio, fatty hilum, water concentration, nZeff and λHU), and 4 most powerful factors (the shortest diameter, fatty hilum, nIC and nZeff) for venous phase. When combining arterial phase and venous phase, four variables (the fatty hilum, arterial phase nZeff, venous phase nZeff and venous phase nIC) were included. In the validation cohort, the AUCs for arterial phase spectral CT model, venous phase spectral CT model and combined arterial-venous phase spectral CT model were 0.89, 0.91, 0.91, respectively. There was no significant difference in AUCs among the three models (DeLong test, P > 0.05 for each comparison).Conclusion We developed a Lasso-logistic model that combined morphologic and quantitative spectral CT parameters of the ALN for preoperative prediction of ALN status in patients with clinical T1/2N0 breast cancer, presenting a non-invasive and highly useful predictive tool for individual preoperative prediction of ALN status in patients with early-stage breast cancer.
Effect of Guided Ahmed Glaucoma Valve Implantation
on Corneal Endothelial Cells: A 2-Year Comparative Study
Authors: Chey Ji Hyoung , Lee Chang Kyu 
Published: July 2022

Abstract
Purpose: To compare the effects of guided and non-guided Ahmed glaucoma valve (AGV) implantation on the corneal endothelium.Methods: Medical records of patients who underwent AGV implantation in the anterior chamber (AC) were reviewed retrospectively. The eyes were divided into two groups depending on the use of a guidance technique with spatula and a 4-0 nylon intraluminal stent. Specular microscopy was performed to measure corneal endothelial cell density (ECD) loss after surgery, and the rate of ECD change was calculated. Tube parameters were measured using anterior segment optical coherence tomography (AS-OCT). Results: The ECD loss during 2 years of follow-up was significantly lower in the guided AGV implantation (gAGV) group than in the non-guided implantation (ngAGV) group, and the rate of ECD change was -0.62 ± 1.23 and -1.42 ± 1.57 %/month in the gAGV and ngAGV groups, respectively (p = 0.003). The mean tube–cornea distance (TCD) and mean tube–cornea angle (TCA) were significantly greater in the gAGV group than in the ngAGV group. The frequency of tube repositioning within 2 years after surgery was 0 % in the gAGV group and 12.66 % in the ngAGV group (p = 0.005). Conclusions: The use of a guidance technique can reduce corneal endothelial loss during the first 2 years after AGV implantation in the AC. The tube was positioned at a more distant and wider angle from the cornea in the eyes of the gAGV group, which may have contributed to the reduced need for tube repositioning to prevent corneal decompensation.
Widespread crystal-melt reequilibration in arc magma reservoirs
Authors: Gao Ke , Keller C Brenhin , Ma Changqian 
Published: July 2022

Abstract
Understanding the mechanisms that control the storage and assembly of subvolcanic and plutonic magma reservoirs in the crust is key to understanding processes ranging from volcanic hazards to the formation and evolution of the continental crust on our unique planet. However, these mechanisms remain poorly understood, with active debate regarding both mode of emplacement, storage, mobilization, and eruption, and conventional case studies are likely insufficient to answer questions regarding the global prevalence of these varying mechanisms. Here, we apply statistical geochemistry and geothermobarometry to global dataset of hornblende-bulk rock pairs from arc-derived igneous rocks. We find that arc plutonic horblende records systematically colder conditions and more felsic equilibrium melts than their volcanic equivalents. Moreover, while our results may be reconciled with either warm- or cold-storage conditions for prevolcanic magma chambers, we find that no combination of remobilization and melt extraction is sufficient to explain the observed disparities, which instead require fundamentally colder conditions in plutonic magma reservoirs relative to those from which the observed volcanic rocks are derived.
Development of a Synthetic Transcription Factor-Based S-adenosylmethionine Biosensor in Saccharomyces cerevisiae
Authors: Zheng Huijie , Yang Jiajia , Cao Yitin , Zhou Huiyun , Chen Ya Wei 
Published: July 2022

Abstract
S-adenosylmethionine (SAM) is a crucial small-molecule metabolite widely used in food and medicine. The development of high-throughput biosensors for SAM biosynthesis can significantly improve the titer of SAM. This paper constructed a synthetic transcription factor (TF)-based biosensor for SAM detecting in Saccharomyces cerevisiae. The synthetic TF, named MetJ-hER-VP16, consists of an Escherichia coli-derived DNA-binding domain MetJ, GS linker, the human estrogen receptor binding domain hER, and the viral activation domain VP16. The synthetic biosensor is capable of sensing SAM in a dose-dependent manner with fluorescence as the output. Additionally, it is tightly regulated by the inducer SAM and β -estradiol, which means that the fluorescence output is only available when both are present together. The synthetic SAM biosensor could potentially be applied for high-throughput metabolic engineering and is expected to achieve biosynthesis of high-titer SAM.
Osculating plane in the Grassmann Gr₂(3,R)
Authors: Santana Gustavo A. , Souza Josiney A. 
Published: July 2022

Abstract
This paper uses concepts of the Lie theory to studying the osculating plane of a regular curve. The osculating plane variation is represented by a smooth curve in the Grassmann manifold Gr₂(3,R). Its velocity coincides with the modulus of the torsion. The curves in Gr₂(3,R) that describe osculating plane variations are completely determined. The results of the paper are applied to the study of helices. It is proved that a general helix depends on a vector field in the Lie algebra so(3,R) and a controlling scalar function.Mathematics Subject Classification (2020): 53A04; 53B20; 53C30.
Distinguishing the Dimensions of the original Dysfunctional Attitude Scale in an Archival Clinical Sample
Authors: Brown Gary , Delgadillo Jaime , Golino Hudson 
Published: July 2022

Abstract
The Dysfunctional Attitude Scale (DAS; Weissman, 1979) measures depression related enduring beliefs and is one of the core measures of cognitive behavioral (CBT) research and theory. It has been the central marker of etiological claims of CBT, and so any change to the understanding of the composition of the DAS would have potentially far-reaching implications for a large body of literature. We sought to capitalize on advances in psychometric techniques since the original 100-item DAS was last analyzed in a sufficiently large clinical sample by Beck et al. (1991) to provide a definitive measurement model of this important instrument. Beyond the two dimensions usually found on the shorter forms of the scale, we identified the following subscales: Imperatives, Cognitive Flexibility, and Negative Expectancy. Initial validity analyses were carried out within the context of an updated CBT theoretical framework informed by the extensive body of research using the DAS over the decades, highlighting the potential for the new subscales to unlock the solution to perennial contradictory findings using the DAS. The richer and more precise DAS structure renews its potential to meet the challenge of predicting who is prone to develop depression or experience a recurrence.
Mel spectrogram based audio forgery detection using CNN
Authors: USTUBIOGLU Arda , USTUBIOGLU Beste , ULUTAS Guzin 
Published: July 2022

Abstract
In this time of technology, digital speech can be created and falsified by a very diverse of hardware and software technologies. Audio Copy-move forgery is an audio forgery technique that goals to create forged audio by hiding undesirable words or repeating wanted words in the identical speech. Therefore, audio authentication has been a necessary requisition. In this study, an effective approach to spectral images based on audio copy-move forgery detection using Convolutional Neural Networks (CNN) with data augmentation is proposed. There are only a few hand-crafted methods conducted for the detection of audio copy-move forgery. None of the existing works on audio copy-move forgery detection has proposed deep feature learning from speech recording with Mel spectrogram. This is the first method to employ deep learning with Mel spectrogram of audio for the detection of audio copy-move forgery. The proposed CNN architecture classifies the suspicious Mel spectrogram images into two classes: original and forged. The proposed CNN system is successfully trained on these Mel spectrogram images feature extraction. The proposed algorithm has been tested on our datasets generated from Arabic Speech Corpus and TIMIT speech database. The results show the effectiveness, robustness to post-processing operations, and high accuracy of the proposed approach compared to other studies.
An Efficient Algorithm Supporting Batch Trajectory Similarity Query Processing
Authors: Wang Xite , Zhan Rongjuan , Bai Mei , Ma Qian , Li Guanyu 
Published: July 2022

Abstract
Trajectory similarity query processing is one of the hot issues in the field of trajectory data analysis, and it is widely used in many aspects. In a large-scale online system, a large number of trajectory similarity queries request may be received in a short period of time. An excellent batch processing algorithm is urgently needed to reduce system load and improve throughput. At present, the studies on batch trajectory similarity query processing lacks consideration of the similarity between query trajectories in query grouping, which cannot meet the needs of high-throughput trajectory similarity query processing. In response to the above problems, a series of new query processing methods are proposed in this paper, which follow two steps of filtering and verification. First, a new index supporting Accelerated Trajectory Query (ATQ) is proposed to effectively filter useless trajectories. Second, on the basis of the ATQ index, we propose a Batch Query Trajectory Grouping (BQTG) algorithm. BQTG divides the received queries into several groups. Queries in the same group have high similarity and can share intermediate results as much as possible. Then, a Basic Algorithm for Batch Trajectory Similarity Query Processing( BABTSQP) is proposed. In each group, BABTSQP continuously selects the main query, which can share lots of intermediate results to answer other queries in the group and reduce many calculations. We also propose an Optimization Algorithm for Batch Trajectory Similarity Query Processing(OABTSQP), which preferentially calculates the trajectories that are close to the query trajectories in the group, so as to obtain a better threshold and achieve a better pruning effect. Finally, the effectiveness of the proposed BABTSQP and OABTSQP algorithms is verified through lots of experiments.
Hand cooling enhances the proprioceptive drift during rubber hand illusion
Authors: Sakamoto Masanori , Akaike Yuta , Tatsumi Kazuya , Ifuku Hirotoshi 
Published: July 2022

Abstract
The neural representation of the body is easily altered by integrating multiple sensory signals in the brain. The “rubber hand illusion” (RHI) is one of the most popular experimental paradigms to investigate this phenomenon. During this illusion, ownership of a rubber hand is created. It was shown that external and continuous cooling of the palm enhanced the RHI, suggesting an association between disrupting the autonomic nervous system regulation and disrupting the sense of ownership of a specific limb. However, the effects of artificially cooling the entire hand for a short period on the magnitude of the illusion remain unknown. Here we show that cooling the hand by immersing it in water for 1 min enhanced the RHI strength. We found that cooling the entire hand enhanced the proprioceptive drift during the RHI but not the subjective feeling of ownership. In contrast, warming and intense cooling of the entire hand did not affect the RHI strength. Our results suggest that transient and moderate cooling of the entire hand was sufficient in enhancing the illusory disembodiment of one’s own hand.
Hyperglycaemia-Induced Impairment of the Autorhythmicity and Gap Junction Activity of Mouse Embryonic Stem Cell-Derived Cardiomyocyte-Like Cells
Authors: Menzele Amanda , Aboalgasm Hamida , Ballo Robea , Gwanyanya Asfree 
Published: July 2022

Abstract
Diabetes mellitus with hyperglycaemia is a major risk factor for malignant cardiac dysrhythmias. However, the underlying mechanisms remain unclear, especially during the embryonic developmental phase of the heart. This study investigated the effect of hyperglycaemia on the pulsatile activity of stem cell-derived cardiomyocytes. Mouse embryonic stem cells (mESCs) were differentiated into cardiac-like cells through embryoid body (EB) formation, in either baseline glucose or high glucose conditions. Action potentials (APs) were recorded using a voltage-sensitive fluorescent dye and gap junction activity was evaluated using scrape-loading lucifer yellow dye transfer assay. Molecular components were detected using immunocytochemistry and immunoblot analyses. High glucose decreased the spontaneous beating rate of EBs and shortened the duration of onset of quinidine-induced asystole. Furthermore, it altered AP amplitude, but not AP duration, and had no impact on the expression of the hyperpolarisation-activated cyclic nucleotide-gated isoform 4 (HCN4) channel nor on the EB beating rate response to ivabradine nor isoprenaline. High glucose also decreased both the intercellular spread of lucifer yellow within an EB and the expression of the cardiac gap junction protein connexin 43 as well as upregulated the expression of transforming growth factor beta 1 (TGFβ1) and phosphorylated Smad3. High glucose suppressed the autorhythmicity and gap junction conduction of mESC-derived cardiomyocytes, via mechanisms probably involving TGFβ1/Smad3 signalling. The results allude to glucotoxicity related proarrhythmic effects, with potential clinical implications in foetal diabetic cardiac disease.
Experimental study on seepage and fracture development law of rainfall slope based on direct current electric method
Authors: KANG Ensheng , Zhexi ZHAO , MENG Haidong 
Published: July 2022

Abstract
In order to study the seepage law and fracture evolution characteristics of waste dump slope, a simulation test system for rainfall instability and failure evolution of large-scale waste dump slope is independently developed under the engineering background of waste dump slope under rainfall conditions. According to the seepage law and fracture evolution characteristics of the waste dump slope, the simulation test of the waste dump rainfall process monitored by the DC resistivity method is carried out. The research results show that there is an obvious negative correlation between the complete slope soil resistivity and the water content. The resistivity increases during the development of the slope fracture and decreases during the water infiltration; Under the influence of rainfall conditions, the internal resistivity value of the waste dump slope shows a downward trend during the 0-5th rainfall, shows a linear downward trend after the fluctuation rises to a gentle level during the 6-90th rainfall, and shows a sharp fluctuation during the 91-110th rainfall; The evolution process of waste dump slope fracture has experienced three stages: saturated water of slope soil, the initiation and expansion of capillary zone, the formation of dominant water channel, and the formation and expansion of waste dump slope fracture. The test results have certain guiding significance for the study of waste dump slope and disaster prevention.
C3aR in astrocytes mediates post-thoracotomy pain by inducing A1 astrocytes in male rats
Authors: Zhu Afang , Cui Huan , Su Wenliang , Liu Chaoqun , Yu Xuerong , Huang Yuguang 
Published: July 2022

Abstract

Background: Astrocytes activation, which is polarized into neurotoxic A1, neuroprotective A2, and classical A-pan, is thought to be involved in the transition from acute to chronic post-thoracotomy pain. The C3aR receptor associated with astrocyte-neuron and -microglia interactions is necessary for A1 astrocytes polarization. This study aimed to determine whether C3aR in astrocytes mediates post-thoracotomy pain by inducing A1 expression in rats thoracotomy pain model. Methods: Thoracotomy pain model was made in male rats, and mechanical withdraw threshold was measured to evaluate pain behavior. Lipopolysaccharide (LPS) was injected intraperitoneally to induce A1 astrocytes. Intrathecal injection of AAV2/9-rC3ar1 shRNA-GFAP was used to knock down C3aR expression in astrocytes in vivo. The expression of associated phenotypic markers before and after intervention was assessed by RT-PCR, western blotting, co-immunofluorescence, and single-cell RNA sequencing. Results: We found that C3aR downregulation inhibited LPS-induced A1 astrocytes activation; decreased the expression of C3aR, C3, and GFAP, which were activated from acute to chronic pain; and alleviated the mechanical withdrawal threshold and incidence of chronic pain. In addition, more A2 astrocytes were activated in the model group that did not develop chronic pain; C3aR downregulation increased the number of A2 astrocytes upon LPS exposure. Knockdown of C3aR also decreased the activation of M1 microglia induced by LPS or thoracotomy. Conclusion: Our study confirmed that C3aR-induced A1 polarization contributed to chronic post-thoracotomy pain. Inhibition of A1 activation via C3aR downregulation increased anti-inflammatory A2 and decreased pro-inflammatory M1 activation, which may also be involved in the mechanism of chronic post-thoracotomy pain.
Integrating Local Science and School Science: The Benefits for the Preservation of Local Wisdom and Promoting Students’ Learning
Authors: Kasi Yohanes Freadyanus , Widodo Ari , Samsudin Achmad , Riandi Riandi 
Published: July 2022

Abstract
Integrating local science in science learning is beneficial for students as well as for the culture. However, the teaching of science tends to focus only on the scientific content presented in the books but ignores the local culture. This paper explores local science in community cultural activities to be implemented in science learning to introduce students to cultural values following the concept of science. It identifies local science, describes the oral arguments produced by the tribal council, and analyzes the lesson plan by five science teachers in the Nagekeo district, East Nusa Tenggara. The data used in this analysis are observation and identification, interviews, and assessment sheets. The findings show that the local science in Nagekeo cultural activities that can be integrated into science learning includes the traditional unit and measurement systems, Newton's laws in their application to the traditional game, biodiversity in the hunt traditional, the concept of heat transfer, and its application in the construction of traditional houses, and vibrations, waves, and sounds in the traditional musical instrument. Recommendations from this research is embracing local science in science learning so that it can provide meaningful learning for students and preserve local culture for each generation in the future so that it does not become extinct.
Differential responses of growth, metals accumulation, oxidative stress and Osmo-compatible solutes in the Halophyte Tamarix gallica under Arsenic and Aluminum stress alone or combined with salt
Authors: SGHAIER Dhouha Belhadj , Duarte Bernardo , CAÇADOR Isabel , SLEIMI Noomene 
Published: July 2022

Abstract
In order to evaluate the ecological risk generated by the heavy metals cumulation in salt-affected soils. The research was carried out in the halophyte Tamarix gallica which is known to thrive under harsh environmental occurrences. The main aim of this work was to study the tolerance and accumulation capabilities of Tamarix gallica under Arsenic, Aluminium and salt stress. Plants were cultivated in the presence of increasing concentrations of Al and As alone (200, 500 and 800 µM), or mixed with NaCl (200 mM). The results revealed that both metals altered the growth and development of T.gallica. Finding showed that the metals’ accumulation was dependent on the concentrations of the metals in the medium. Interestingly, while salt reduced As uptake, an augmentation in Al accumulation was observed. In addition, T. gallica demonstrated that APX was the predominant enzyme to scavenge excess ROS. However, SOD and GPX were sensitive to the metal, showing different behaviour in metal stress alone or combined with salt. Proline accumulated in a dose-dependent manner under Al and As stress, rather than lower or unchanged levels of glycine betaine. We also noticed a diminution in proline content caused by NaCl application while an increase in glycine betaine was remarked. On the other hand, the combined stress enhanced proline whereas unchanged levels of glycine betaine were observed. Finally, T. gallica demonstrated its potential to grow under elevated concentrations of As/Al and could be considered a suitable candidate for phytostabilization/ phytoremediation approach.