bluuebunny/crossref_metadata_2025_split huggingface dataset:
High salt diet does not impact the development of acute myeloid leukemia in mice
Authors: Janakiraman Mathangi , Salei Natallia , Krishnamoorthy Gurumoorthy 
Published: July 2022

AbstractThe gut microbiota has not only been implicated in the development of some cancers but has also been shown to modulate the efficacy of cancer therapeutics. Although the microbiota is an attractive target in cancer therapy, there is limited data available regarding the relevance of microbiota and dietary interventions in the various types of tumors. Recently, a high salt diet (HSD) has attracted attention in cancer development owing to its profound effects on modulating microbiota and immune responses. Here, we investigated the impact of HSD on microbiota, immune responses, and the development of acute myeloid leukemia using two syngeneic transplantation models. HSD significantly changes the microbiota composition, TH17 responses, and NK cells. However, we found no influence of HSD on tumor development. The kinetics and characteristics of tumor development were similar despite varying the number of injected tumor cells. Our data show that the effects of the microbiome and dietary interventions can be tumor-specific and may not apply to all types of cancers.
Tadalafil monotherapy in management of chronic prostatitis/chronic pelvic pain syndrome: a randomized double-blind placebo controlled clinical trial
Authors: Tawfik Ahmed M. , Radwan Mohammed H. , Abdulmonem Mohammed , Abo-Elenen Mohammed , Elgamal Samir A. , Aboufarha Mohammed O. 
Published: July 2022

Abstract
Purpose
In this placebo-controlled trial, we aimed to evaluate the clinical results of using PDE-5 inhibitor, tadalafil 5 mg OD, for management of CP/CPPS.

Patients and methods
140 patients ≤ 45 years old with moderate/severe CP/CPPS associated with ED (IIEF-5 < 22) were randomly divided and received either tadalafil 5 mg OD (tadalafil-group) or placebo (control-group) for 6 weeks. Post-treatment CPSI scores were compared to baseline and to placebo. Clinically significant responders (≥ 25% reduction from baseline score) were calculated. Tadalafil-induced changes in IIE-5 were evaluated in correlation to that of CPSI scores.

Results
By the 6th week, 59 and 56 patients were available in both groups respectively. Compared to baseline, tadalafil-group patients showed significant improvement in total, pain, urinary and Qol domains of CPSI (19.1 ± 5.26, 10.42 ± 3.55, 4.2 ± 1.72 and 4.47 ± 1.64 vs. 24.21 ± 5.05, 12.14 ± 3.57, 6.08 ± 1.53 and 6.22 ± 1.76), p < 0.5. When compared to placebo, all 6th week CPSI domains scores, except for pain, were significantly better in tadalafil-group (p < 0.05). Post-treatment pain score didn't significantly differ between both groups (10.42 ± 3.55, vs. 11.71 ± 3.9, p > 0.05). Clinically significant responders were 30 patients (50.8%) in tadalafil-group vs. 3 patients (5.4%) in control. Tadalafil-induced changes in IIEF-5 score had weak but significant correlation to Qol domain (r = − 0.28, p < 0.05).

Conclusion
Tadalafil 5 mg OD can significantly improve all CPSI domains as compared to baseline. Post-treatment CPSI scores, except for pain, were better than placebo. About 50.8% of patients can develop ≥ 25% reduction in their total CPSI scores after treatment. Apart from Qol domain, these changes are not significantly correlated to tadalafil-induced IIEF-5 scores changes.
Surgical explantation of failed transcatheter heart valves: indications and results
Authors: Muensterer Andrea , Puluca Nazan , Ruge Hendrik , Vitanova Keti , Lange Ruediger 
Published: July 2022

AbstractGiven the recent surge in transcatheter heart valve replacement (THVR), cardiac surgeons will surely face the challenge of eventual explantation. The aim of this study was to determine indications for reoperation, while exploring pertinent technical aspects and survival after THV explantation in a cohort originally deemed high risk or even inoperable. Between February 2008 and March 2019, 31 patients with failed transcatheter aortic valve replacement (TAVR) underwent surgical explantations at our facility. Data were prospectively collected for retrospective analysis of procedural indications, technical issues, and postoperative survival. The major reason for TAVR removal was bioprosthetic valve failure (BVF) due to infective endocarditis (IE: 16/31 [51.6%]), non-structural (NSVD: 14/31 [45.2%]) and structural (SVD: 1/31 [3.2%]) valve deterioration accounting for the rest. Mean age at THV explantation was 76.3 ± 8.3 years, and median time from TAVR to explantation was 153 days (0 days–56.6 months). Median ICU and hospital stay were 6 days (1–44 days) and 23 days (8–62 days), respectively. Thirty-day and 1-year survival rates were 74.2% and 67.2%, respectively. Median follow-up interval after explantation was 364 days (3 days–80 months). Mean cardiopulmonary bypass time was 124.6 ± 46.8 min, and mean aortic cross-clamp time was 84.3 ± 32.9 min. There was no need for unplanned aortic root repair owing to tissue damage during dissection of the TAVR from surrounding tissue. The most common reason for THV explantation was (a) BVF for IE and (b) BVF secondary to NSVD. Although 30-day and 1-year mortality rates in this multimorbid cohort were predictably high, no procedural mortalities occurred.
Males and females with first episode psychosis present distinct profiles of social cognition and metacognition
Authors: Ferrer-Quintero M. , Fernández D. , López-Carrilero R. , Birulés I. , Barajas A. , Lorente-Rovira E. , Luengo A. , Díaz-Cutraro L. , Verdaguer M. , García-Mieres H. , Gutiérrez-Zotes A. , Grasa E. , Pousa E. , Huerta-Ramos E. , Pélaez T. , Barrigón M. L. , Gómez-Benito J. , González-Higueras F. , Ruiz-Delgado I. , Cid J. , Moritz S. , Sevilla-Llewellyn-Jones J. ,   Spanish Metacognition Group, Acevedo A. , Anglès J. , Argany M. A. , Barajas A. , Barrigón M. L. , Beltrán M. , Birulés I. , Bogas J. L. , Cabezas A. , Camprubí N. , Carbonero M. , Carrasco E. , Casañas R. , Cid J. , Conesa E. , Corripio I. , Cortes P. , Crosas J. M. , de Apraiz A. , Delgado M. , Domínguez L. , Escartí M. J. , Escudero A. , Pinos I. Esteban , Franco C. , García C. , Gil V. , Gonzalez-Casares R. , González Higueras F. , González-Montoro M. L. , González E. , Grasa E. , Guasp A.. , Gutierrez-Zotes A. , Huerta-Ramos M. E. , Huertas P. , Jiménez-Díaz A. , Lalucat L. L. , LLacer B. , López-Carrilero R. , Lorente E. , Luengo A. , Mantecón N. , Mas-Expósito L. , Montes M. , Moritz S. , Murgui E. , Nuñez M. , Ochoa S. , Palomer E. , Paniego E. , Peláez T. , Pérez V. , Planell K. , Planellas C. , Pleguezuelo-Garrote P. , Pousa E. , Rabella M. , Renovell M. , Rubio R. , Ruiz-Delgado I. , San Emeterio M. , Sánchez E. , Sanjuán J. , Sans B. , Schilling L. , Sió H. , Teixidó M. , Torres P. , Vila M. A. , Vila-Badia R. , Villegas F. , Villellas R. , Ochoa S. 
Published: July 2022

AbstractDeficits in social cognition and metacognition impact the course of psychosis. Sex differences in social cognition and metacognition could explain heterogeneity in psychosis. 174 (58 females) patients with first-episode psychosis completed a clinical, neuropsychological, social cognitive, and metacognitive assessment. Subsequent latent profile analysis split by sex yielded two clusters common to both sexes (a Homogeneous group, 53% and 79.3%, and an Indecisive group, 18.3% and 8.6% of males and females, respectively), a specific male profile characterized by presenting jumping to conclusions (28.7%) and a specific female profile characterized by cognitive biases (12.1%). Males and females in the homogeneous profile seem to have a more benign course of illness. Males with jumping to conclusions had more clinical symptoms and more neuropsychological deficits. Females with cognitive biases were younger and had lower self-esteem. These results suggest that males and females may benefit from specific targeted treatment and highlights the need to consider sex when planning interventions.
Racial-ethnic diversity in ambulatory blood pressure monitoring in children with chronic kidney disease
Authors: Pagi Reut , Yadin Ora , Wesseling-Perry Katherine , Norris Keith , Laster Marciana Lee 
Published: July 2022

AbstractBackgroundBlack adults with chronic kidney disease (CKD) have higher rates of hypertension as compared to White adults with CKD. Little is known of how race and ethnicity associate with the prevalence of hypertension in pediatric CKD patients. The aim was to compare ambulatory blood pressure monitoring (ABPM) results for patients with CKD enrolled in the Chronic Kidney Disease in Children (CKiD) study across racial-ethnic groups.MethodsPatients from the CKiD study who identified as non-Hispanic White, non-Hispanic Black, or Hispanic were included to analyze differences in ABPM results across these racial-ethnic groups. The outcomes were fitted using 3 progressively adjusted models.ResultsThis study included 501 CKiD participants with at least one successful ABPM study. Compared to White participants, Black participants had 4.2 mmHg higher mean sleep systolic blood pressure and 2.7 mmHg higher mean sleep diastolic blood pressure (p = 0.001 andp = 0.004, respectively). Additionally, Black participants had higher odds of abnormal wake systolic load (OR1.88, 1.21–2.91,p = 0.005), wake diastolic load (OR1.68, 1.03–2.73,p = 0.04), sleep systolic load (OR2.19, 1.36–3.5,p = 0.001), sleep diastolic load (OR2.01, 1.28–3.15,p = 0.002), systolic non-dipping (OR2.02, 1.31–3.10,p = 0.001), and diastolic non-dipping (OR2.69, 1.60–4.51,p < 0.001). Compared to White participants, Hispanic participants demonstrated only a lower sleep diastolic load (OR0.54, 0.31–0.95,p = 0.03).ConclusionsBlack children with CKD have higher absolute nocturnal blood pressures and higher rates of abnormal dipping. Further studies are needed to determine the etiology of these differences and the clinical implications of racial-ethnic differences in ABPM outcomes within the pediatric CKD population.Graphical abstractA higher resolution version of the Graphical abstract is available as Supplementary information
Unique underlying principles shaping copper homeostasis networks
Authors: Novoa-Aponte Lorena , Argüello José M. 
Published: July 2022

Abstract
Copper is essential in cells as a cofactor for key redox enzymes. Bacteria have acquired molecular components that sense, uptake, distribute, and expel copper ensuring that cuproenzymes are metallated and steady-state metal levels are maintained. Toward preventing deleterious reactions, proteins bind copper ions with high affinities and transfer the metal via ligand exchange, warranting that copper ions are always complexed. Consequently, the directional copper distribution within cell compartments and across cell membranes requires specific dynamic interactions and metal exchange between cognate holo-apo protein partners. These metal exchange reactions are determined by thermodynamic and kinetics parameters and influenced by mass action. Then, copper distribution can be conceptualized as a molecular system of singular interacting elements that maintain a physiological copper homeostasis. This review focuses on the impact of copper high-affinity binding and exchange reactions on the homeostatic mechanisms, the conceptual models to describe the cell as a homeostatic system, the various molecule functions that contribute to copper homeostasis, and the alternative system architectures responsible for copper homeostasis in model bacteria.

Graphical Abstract
The putative role of trigemino-vascular system in brain perfusion homeostasis and the significance of the migraine attack
Authors: De Simone Roberto , Sansone Mattia , Russo Cinzia , Miele Angelo , Stornaiuolo Antonio , Braca Simone 
Published: July 2022

AbstractBesides representing the place where a migraine attack generates, what is the physiological role of peptidergic control of arteriolar caliber within the trigemino-vascular system? Considering that the shared goal of most human CGRP-based neurosensory systems is the protection from an acute threat, especially if hypoxic, what is the end meaning of a migraine attack? In this paper, we have reviewed available evidence on the possible role of the trigemino-vascular system in maintaining cerebral perfusion pressure homeostasis, despite the large physiological fluctuations in intracranial pressure occurring in daily life activities. In this perspective, the migraine attack is presented as the response to a cerebral hypoxic threat consequent to a deranged intracranial pressure control aimed at generating a temporary withdrawal from the environment with limitation of physical activity, a condition required to promote the restoration of cerebral fluids dynamic balance.
Suggestions for marine protected area management in Australia: a review of temperature trends and management plans
Authors: Tan Jia Sheng Danny , Fischer Andrew M. 
Published: July 2022

AbstractClimate change and related ocean warming have affected marine ecological and socioeconomic systems worldwide. Therefore, it is critically important to assess the performance of conservation mechanisms, particularly marine protected areas (MPAs) to moderate the risks of climate-related impacts. In this study, sea surface temperature trends of Australian Commonwealth MPAs are assessed against climate change management criteria, as defined in Adapting to Climate Change: Guidance for Protected Area Managers and Planners. Monthly sea surface temperature trends between 1993 and 2017 were statistically assessed using the Mann–Kendall trend test and management plans were subject to a thematic analysis. Temperature trends showed variable SST changes among the regions, with the northern reserves all showing statistically significant increases in temperature, and the Southwest Network having the least number of reserves with statistically significant increases in temperature. The thematic analysis shows that management plans address approximately half of the climate change adaptation criteria. Several management strategies, such as dynamic MPAs, replication, and translocations, are currently absent and have been suggested as necessary tools in supporting the climate readiness of Australian MPAs. This study is significant because it helps to identify and synthesize regions most vulnerable to the impacts of ocean warming and provides management suggestions make MPAs “climate ready.”
First-in-human study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors
Authors: Janku Filip , Beom Seung-Hoon , Moon Yong Wha , Kim Tae Won , Shin Young G. , Yim Dong-Seok , Kim Gun Min , Kim Hyo Song , Kim Sun Young , Cheong Jae-Ho , Lee Young Woo , Geiger Barb , Yoo Sanghee , Thurston Archie , Welsch Dean , Rudoltz Marc S. , Rha Sun Young 
Published: July 2022

AbstractPreclinical models suggest anticancer activity of IM156, a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS). This first-in-human dose-escalation study enrolled patients with refractory advanced solid tumors to determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D). Eligible patients received oral IM156 every other day (QOD) or daily (QD) and were assessed for safety, dose-limiting toxicities (DLTs), pharmacokinetics, and preliminary signals of efficacy. 22 patients with advanced cancers (gastric, n = 8; colorectal, n = 3; ovarian, n = 3; other, n = 8) received IM156 100 to 1,200 mg either QOD or QD. There were no DLTs. However, 1,200 mg QD was not well tolerated due to nausea; 800 mg QD was determined as the RP2D. The most frequent treatment-related AEs (TRAEs) were nausea (n = 15; 68%), diarrhea (n = 10; 46%), emesis (n = 9; 41%), fatigue (n = 4; 18%) and abdominal pain, constipation, and blood lactate increased (n = 2 each; 9%). Grade 3 nausea (n = 3; 14%) was the only grade ≥ 3 TRAE. Plasma exposures increased dose proportionally; mean Day 27 area under the curve (AUC0-24) values were higher following QD administration compared to the respective QOD regimen. Stable disease (SD), observed in 7 (32%) patients (confirmed in 2 [9%]), was the best response. To our knowledge, this is the first phase 1 study of an OXPHOS inhibitor that established a RP2D for further clinical development in cancer. Observed AEs of IM156 were manageable and SD was the best response.
Basic Values Transform Political Interest into Diverse Political Values, Attitudes and Behaviors
Authors: Stattin Håkan , Amnå Erik 
Published: July 2022

AbstractSince politically interested adolescents do not necessarily present humanistic, environmental and democratic values, this study addresses the hitherto ignored role that how these basic human values play in politically interested adolescents’ political values, attitudes and behaviors. A cluster analysis of 857 Swedish upper-secondary students (50.8% girls, Mage = 16.62, SD = 0.71) identified politically interested adolescents who attached high levels of importance to others’ welfare and politically interested adolescents who attached low levels of importance. They differed on most comparative measures: environmental values, inclusive attitudes towards immigrants, support of democratic principles, trust in social movements, and readiness to step in if something jeopardizes the welfare of others. The conclusion is that the value of attaching high importance to others’ welfare or not transforms youth’s political interest into diverse attitudes and behaviors. The cluster group of politically interested adolescents who attached low importance to others’ welfare largely consisted of males.
The semantics of exceptives
Authors: Peters Stanley , Westerståhl Dag 
Published: July 2022

AbstractThis paper gives a uniform account of the meaning of generalizations with explicit exceptions that employ the prepositions “but”, “except”, and “except for”. Our theory is that exceptives depend on generalizations, which can but need not be universal, whose generality they limit, and some of whose exceptions they comment on. Every generalization intrinsically partitions its domain of applicability into regular cases, which are as it says to expect, and exceptions, which are not. A generalization’s exceptions are instances that falsify it if sufficiently prevalent. These two facts underpin the meaning of exceptives as combining a generality claim with an exception claim, giving correct truth conditions for the several ways the three exceptive prepositions are used, and significantly improving on existing semantic accounts in the literature. We support this by analyzing a wide range of examples. The analysis applies whether or not the phrase following the exceptive preposition is a DP, and whether or not the generalization is expressed with a quantifier. We further argue that these exceptive prepositions are synonymous, contrary to the widely held view that a difference in meaning explains their different syntactic distributions.
Optimizing subgraph matching over distributed knowledge graphs using partial evaluation
Authors: Song Yanyan , Qin Yuzhou , Hao Wenqi , Liu Pengkai , Li Jianxin , Choudhury Farhana Murtaza , Wang Xin , Zhang Qingpeng 
Published: July 2022

AbstractThe partial evaluation and assembly framework has recently been applied for processing subgraph matching queries over large-scale knowledge graphs in the distributed environment. The framework is implemented on the master-slave architecture, endowed with outstanding scalability. However, there are two drawbacks of partial evaluation: if the volume of intermediate results is large, a large number of repeated partial matches will be generated; and the assembly computation handled by the master would be a bottleneck. In this paper, we propose an optimal partial evaluation algorithm and a filter method to reduce partial matches by exploring the computing characteristics of partial evaluation and assembly framework. (1) An index structure named inner boundary node index (IBN-Index) is constructed to prune for graph exploration to improve the searching efficiency of the partial evaluation phase. (2) The boundary characteristics of local partial matches are utilized to construct a boundary node index (BN-Index) to reduce the number of local partial matches. (3) The experimental results over benchmark datasets show that our approach outperforms the state-of-the-art methods.
Retinal abnormalities, although relatively common in sleep clinic patients referred for polysomnography, are largely unrelated to sleep-disordered breathing
Authors: Amis Terence C. , Perri Rita , Lee Sharon , Wickens Meredith , Liew Gerald , Mitchell Paul , Kairaitis Kristina , Wheatley John R. 
Published: July 2022

Abstract
Study objectives.
There has been long-standing interest in potential links between obstructive sleep apnea (OSA) and eye disease. This study used retinal photography to identify undiagnosed retinal abnormalities in a cohort of sleep clinic patients referred for polysomnography (PSG) and then determined associations with PSG-quantified sleep-disordered breathing (SDB) severity.

Methods
Retinal photographs (n = 396 patients) were taken of each eye prior to polysomnography and graded according to validated, standardized, grading scales. SDB was quantified via in-laboratory polysomnography (PSG; n = 385) using standard metrics. A questionnaire (n = 259) documented patient-identified pre-existing eye disease. Within-group prevalence rates were calculated on a per patient basis. Data were analyzed using multivariate logistic regression models to determine independent predictors for retinal abnormalities. P < 0.05 was considered significant.

Results
Main findings were (1) 76% of patients reported no pre-existing “eye problems”; (2) however, 93% of patients had at least one undiagnosed retinal photograph-identified abnormality; (3) most common abnormalities were drusen (72%) and peripapillary atrophy (PPA; 47%); (4) age was the most common risk factor; (5) diabetes history was an expected risk factor for retinopathy; (6) patients with very severe levels of SDB (apnea hypopnea index ≥ 50 events/h) were nearly three times more likely to have PPA.

Conclusion
Retinal photography in sleep clinic settings will likely detect a range of undiagnosed retinal abnormalities, most related to patient demographics and comorbidities and, except for PPA, not associated with SDB. PPA may be indicative of glaucoma, and any association with severe SDB should be confirmed in larger prospective studies.
The Right to Associational Freedom and the Scope of Relationship-Dependent Duties
Authors: Betzler Monika 
Published: July 2022

AbstractHumans have a fundamental need to belong. This, need, as Kimberley Brownlee argues in her book Being Sure of Each Other grounds the human right against social deprivation. But in addition to having a human right against social deprivation, we also have a right to associational freedom, which is grounded in our right to autonomy. We cannot be forced into relationships; we are free to choose our friends and loved ones.? In this paper I discuss what our right to associational freedom morally permits us to do when are already in an intimate relationship and, relatedly, what our relationship-dependent duties require of us in such cases. What exactly are the constraints on our right to associational freedom? And what is the content and scope of our relationship-dependent duties, given that our right to associational freedom conflicts with the fulfillment of these duties?? After providing some clarifications as to how we should understand intimate relationships that have ended, I will first highlight what relationship-dependent duties are and how they correlate with a right to associational control. I will then discuss several break-up scenarios, the aim of which is to determine the conditions that justify constraints being imposed on the right to associational freedom and to delineate the scope of relationship-dependent duties.