bluuebunny/crossref_metadata_2025_split huggingface dataset:
The fire safety of infrastructure facilities for hydrogen-powered vehicles
Authors: Gordienko D. M. , Shebeko Yu. N. 
Published: June 2022

Introduction. The article offers an analytical review of domestic and foreign publications on the fire safety of hydrogen refueling stations and garages for hydrogen-powered vehicles.General characteristics of the fire hazard of infrastructure facilities for hydrogen-powered vehicles. The authors offer the general characteristic of a specific fire hazard from facilities using compressed and liquid hydrogen.Hydrogen refueling stations. Refueling stations using compressed and liquid hydrogen were considered in the article. It was found that compressors are the most hazardous items installed at refueling stations; therefore, the value of potential risks, arising in the area of a refueling station, exceeds 10–4 year–1. Experiments, simulating accidents at hydrogen refueling stations, are described. According to the authors, the minimal distance between the compressor and facilities located outside the station area should exceed 50 m.Garages for hydrogen-powered vehicles. Features of the fire safety of garages for hydrogen-powered vehicles were analyzed. The authors have found that the overpressure inside a small garage (an individual garage) can reach 55 kPa in case of a jet flame caused by the release of hydrogen through the safety valves of fuel tanks. The overpressure of a hydrogen jet can reach 10 kPa in case of the unignited release of hydrogen. High pressure values that accompany the jet formation are triggered by the high normal burning velocity of hydrogen that boosts the velocity of heat release in the flame front, exceeding the same value for flares of hydrocarbon gases. Therefore, requirements, applicable to storage premises designated for vehicles powered by hydrocarbon fuel, may be erroneously extended to garages for hydrogen-powered vehicles (pursuant to NFPA 2).Conclusions. The results of this analysis can be contributed to regulatory documents to be developed in the area of fire safety of infrastructure facilities for hydrogen-powered vehicles.
Current requirements to designing fire protection systems for educational establishments
Authors: Pekhotikov A. V. , Poletaev A. N. , Gomozov A. V. , Usolkin S. V. 
Published: June 2022

Introduction. It is necessary to update requirements for designing fire protection systems for these facilities in terms of the safe evacuation and rescue of children and personnel, increase the efficiency of fire emergency response units conducting rescue operations, as well as optimize space planning and structural solutions to ensure a high level of fire safety inside buildings of preschool and general education organizations.Goals and objectives. The purpose of the article is to validate the updated requirements for designing fire protection systems for buildings of preschool and general education organizations in compliance with the Federal Law of the Russian Federation dated July 22, 2008 № 123-FZ «Technical regulations governing fire safety requirements» (hereinafter – «№Law 123-FZ»).Methods. An analytical method is used to formulate and substantiate the requirements for designing fire protection systems for educational establishments within the framework of the integrated application of Law 123-FZ and with regard for current trends in architecture and structural design of similar buildings, as well as fire risk calculations.Results. The results of the work are contributed to the amended sets of effective fire safety rules, such as SP 1.13130.2020 «Fire protection systems. Evacuation routes and exits», SP 2.13130.2020 «Fire protection systems. The fire resistance of protected facilities», SP 4.13130.2013 «Fire protection systems. Restricting fire spread throughout protected facilities. Requirements for space planning and structural solutions» (Amendment 1), etc., as well as SP 251.1325800.2016 «Buildings of general education organizations. Design rules» (Amendment 3).Conclusion. The research findings were employed to substantiate the current requirements for designing fire protection systems for educational establishments to improve the safety of children in the process of evacuation and rescue, if these buildings have premises featuring various classes of functional fire hazard, fire resistance limits and fire hazard classes of building structures, building materials and engineering installations.
Lineamientos para el uso de la hipermedialidad, multimedialidad e interactividad en el ejercicio periodístico digital comunitario para redes sociales (Facebook). Caso de análisis de la Red de Reporteros Comunitarios de Colombia (RRC)
Authors: Ladino Marín Paola Consuelo , Prada Penagos Rodolfo , Adán Diaz Oscar Eduardo 
Published: June 2022

Este artículo busca proponer lineamientos estratégicos para el uso de la hipermedialidad, multimedialidade interactividad en el periodismo comunitario mediado por redes sociales, específicamenteFacebook, tomando como referencia el caso de la Red de Reporteros Comunitarios de Colombia(RRC). Metodológicamente se realizaron tres fases que vincularon: análisis de los recursos digitalesdesde la práctica periodística de la RRC, examinando los baremos de medición de Fondevila (2014)para categorizar los contenidos de la plataforma; un diagnóstico de las herramientas utilizadasen las publicaciones; y una propuesta estratégica que mejore el uso de RRSS en medios comunitarios.Como hallazgos se destaca que los medios comunitarios deben enriquecer e integrar diversosrecursos y géneros del lenguaje periodístico para potencializar sus contenidos. Así como establecerun diálogo permanente con la comunidad, ampliar el uso de enlaces para profundizar contenidos, validarlas normas de redacción en la red, como apoyarse de contenidos infográficos que den contexto,como aspectos asociados a la generación de tráfico, la segmentación de audiencias, el enriquecimientodel diálogo social y la independencia de los ámbitos de poder del Estado.
Para la Unesco la función de este tipo de medios asegura la participación ciudadana, refuerza la libertad de expresión, defiende los Derechos Humanos de la comunidad y promueve el desarrollo social. En esta dimensión, se reconoce que las plataformas sociales han tomado fuerza en la democratización de la información, la movilización de contenidos críticos que dan voz a diversos segmentos de la población y fortalecen los vínculos entre el medio y la comunidad.
Como hallazgos se destaca que los medios comunitarios deben enriquecer e integrar diversos recursos y géneros del lenguaje periodístico para potencializar sus contenidos. Así como establecer un diálogo permanente con la comunidad, ampliar el uso de enlaces para profundizar contenidos, validar las normas de redacción en la red, como apoyarse de contenidos infográficos que den contexto, como aspectos asociados a la generación de tráfico, la segmentación de audiencias, el enriquecimiento del diálogo social y la independencia de los ámbitos de poder del Estado.
Material Sustainability and Stock Return: Faith is Not Enough
Authors: Berchicci Luca , King Andrew A. 
Published: June 2022

ABSTRACT
Yoon and Serafeim (2022) provide a review of the history of materiality, a brief discussion of selected research, and a discourse on measurement noise. They do not address the results of our research, our critique of their analysis, or our evidence that the main finding of Khan, Serafeim, and Yoon (2016) is a statistical artifact. In total, their response illustrates the danger of placing excessive faith in the findings from a single study.
1475-PUB: A Crucial Role of miR-223-3p in Endothelial Cell Injury with Diabetes Kidney Disease
Authors: TANG PING , JINGRONG ZHANG , ZHANG LIHUA 
Published: June 2022

Diabetic kidney disease (DKD) is a leading cause of chronic and end-stage renal failure in the world. However, the underlying molecular mechanisms are various and not completely understood. In our previous study, miR-223-3p was identified as the most significantly decreased miRNAs and showed a disease-dependent expression in the plasma of DKD patients through microarray analysis, which was involved in biological processes, such as cell proliferation, differentiation, apoptosis and immune regulation. In the present study, we firstly used high glucose stimulation to establish human umbilical vein endothelial cells (HUVECs) injury in vitro DKD model and db/db mice in vivo DKD model, respectively.The preliminary qPCR study of related markers (VEGF, ET-1, vWF) and Western bolting analysis of GP130 and p-STAT3 indicated a successful HUVECs injury in vitro DKD model, and the significant increasingly expression of Vegfa, ET-1, vWF mRNA in db/db mice was observed. Most importantly, the expression of miR-223-3p was indeed significantly decreased in both high glucose stimulated HUVECs and db/db DKD mice. Of which, the target gene IL6ST also showed significantly high expression.
In conclusion, these results indicated that the expression change of miR-223-3p in vitro and vivo DKD model may related to endothelial cell injury with DKD progression.
Key words: Diabetic kidney disease (DKD) , miR-223-3p, HUVECs, db/db mice, IL6ST.

Disclosure
P.Tang: None. Z.Jingrong: None. L.Zhang: None.

Funding
National Natural Science Foundation of China (81960156) and Health Science and Technology Program of Yunnan Province[2019FE001 (-040) ]
1476-PUB: The Stimulation of High Glucose Can Downregulate Expression of miR-223-3p in HUVECs, Which May Undergo Endothelial–Myofibroblast Transition
Authors: ZHANG JINGRONG , TANG PING , ZHANG LIHUA , LI PAN 
Published: June 2022

The early changes in renal glomeruli are crux for the development of glomerulosclerosis and nephron dropout in diabetic kidney disease (DKD) . Many studies have focused on the changes of the dysfunction of glomerular podocytes, the study of glomerular endothelial cells (GECs) are not completely understood. Human umbilical vein endothelial cells (HUVECs) are considered the classic model of endothelial cells (ECs) . The stimuliation of high glucose would induce the stress or injury of ECs. In our previous study, with the development of DKD, the the expression of miR-223-3p was significantly decreased in patients’ peripheral plasma, and bioinformatics methods predicted IL6ST as the target gene of miR-223-3p. We also proved that miR-223-3p target IL6ST and down-regulate its expression in 293T cells by using dual-luciferase reporter assay system.So the down-regulation of miR-223-3p could be viewed which induced by high glucose 24 hours in HUVECs and its target gene IL6ST significantly increased. After using high glucose stimulate the HUVECs, the proliferation and migration of HUVECs decreased, the qPCR study suggest that the expression of miR-223-3p significantly decreased, the endothelial jnjury factors (aVEGF, ET1) increased, and the fibrosis factor (αSMA, FN1) also increased. When up-regulate the expression of miR-223-3p in HUVECs by using miR-223-3p-mimic, the expression of IL6ST is down-regulated.The HUVECs may undergo endothelial-myofibroblast transition (EndoMT) after high glucose stimulation, and this process may be one of the cause of DKD glomerulosclerosis.

Disclosure
J.Zhang: None. P.Tang: None. L.Zhang: None. P.Li: None.

Funding
Financial Support: National Natural Science Foundation of China (81960156) , and Health Science and Technology Program of Yunnan Province[2019FE001 (-040) ]
1481-PUB: Gliclazide vs. Linagliptin on the Incidence of Hypoglycemia and Major Adverse Cardiovascular Events in Adults with Type 2 Diabetes: Narrative Synthesis of Systematic Literature Search
Authors: MOHAN VISWANATHAN , WANGNOO SUBHASH KUMAR , DAS SAMBIT , DHEDIYA RAJNISH , GAURAV KUMAR 
Published: June 2022

Background: The CAROLINA, landmark cardiovascular outcome trial (CVOT) , has demonstrated cardiovascular safety of glimepiride against DPP-IV inhibitor linagliptin. Considering the absence of CVOT for Gliclazide, we decided to conduct a systematic review of the literature to assess the cardiovascular (CV) safety and hypoglycemia risk of gliclazide versus linagliptin in patients with T2DM.
Method: A systematic literature search of MEDLINE and Google Scholar was conducted to include all linagliptin ± metformin and gliclazide ± metformin trials from 20onwards that assessed the adverse events: hypoglycemia, myocardial infarction/ischemia, transient ischemic attack, cardiovascular death, and stroke. Two independent reviewers conducted a literature search and study selection according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Only randomized trials, considered the highest quality of evidence by the Oxford Center for Evidence-based Medicine, were included. We excluded placebo-controlled studies and studies comparing gliclazide or linagliptin with metformin.
Results: No trials compared gliclazide ± metformin with linagliptin ± metformin. Hence, it was impossible to directly compare their hypoglycemia and major adverse cardiovascular events (MACE) outcomes. Eight clinical trials were included in the narrative descriptive synthesis (gliclazide 5 and linagliptin 3) . Both drugs effectively achieved the desired glycaemic control and had low MACE and hypoglycemia risk in adults with T2DM. Studies comparing gliclazide with another DPP4 inhibitor, vildagliptin, did not report a significant difference in CV safety and/or hypoglycemia incidence.
Conclusion: Gliclazide can be used safely in patients with T2D in resource-limited settings as it has low MACE and hypoglycemia risk.

Disclosure
V.Mohan: None. S.Wangnoo: None. S.Das: n/a. R.Dhediya: None. K.Gaurav: Employee; Dr. Reddy’s Laboratories Ltd.
1482-PUB: Insulin Receptors in Vascular Smooth Muscle Cells Regulate Plaque Stability by Its actions on Glycolysis and Oxidative Phosphorylation
Authors: LI QIAN , FU JIALIN , PARK KYOUNGMIN , LI QIN , KING GEORGE L. 
Published: June 2022

Vascular smooth muscle cells (VSMC) have prominent roles in the pathology of atherosclerotic plaque, where it forms intimal hyperplasia, maintains extracellular matrix (ECM) and interacts with lipoproteins to accelerate inflammation and formation of foam cells. Diabetes and insulin resistance exacerbate all of these histopathologies of atherosclerotic plaques. Further, diabetes increase the formation of unstable plaques that feature less VSMC and ECM, but more inflammatory cells and necrotic lesions, which, on rupture, cause thrombosis and acute myocardial infarction. We reported that insulin receptors (IR) are responsible for increasing arterial restenosis since mouse with IR deletion in the VSMC showed less proliferation, more apoptosis, and less arterial hyperplasia after intimal injury. Surprisingly, in mice with specific deletion of IR in VSMC (SMIRKO/ApoE-/-) , severity of atherosclerosis was increased and the plaques exhibited unstable pathologies of less VSMC and ECM, but greater levels of macrophages and necrosis than ApoE-/- mice. Analysis of glucose glycolysis (extracellular acidification rate, ECAR) and oxidative phosphorylation (oxygen consumption rate, OCR) , using Seahorse assay, showed dramatically decreased metabolic rates in VSMC from SMIRKO/ApoE-/- compared to ApoE-/- mice. Overexpression of IR in VSMCs increased ECAR and OCR, which were further stimulate by insulin, only in VSMC with IR. [J1] Insulin increased expressions of glycolytic enzymes including hexokinase 2 and phopshofructose kinase in VSMCs overexpressing IR. These findings have identified the importance of IR on the regulation of glycolysis and mitochondrial metabolism in VSMC, which could increase the stability of the atherosclerotic plaques by increased VSMCs proliferation and ECM, but reduced their apoptosis and productions of inflammatory cytokines. [J1]Hard to understand⋯maybe combine with the next phrase?

Disclosure
Q.Li: None. J.Fu: None. K.Park: None. Q.Li: None. G.L.King: Advisory Panel; Medtronic, Research Support; Janssen Pharmaceuticals, Inc.
1486-PUB: Single-Toe Necrosis over Diabetic Foot Ulcer (DFU) : Amputation Surgery at Bedside by a Diabetologist or in the Operating Room by a Surgeon
Authors: FÉRON FLORINE , RIVELINE JEAN-PIERRE , GAUTIER JEAN-FRANÇOIS , KEVORKIAN JEAN-PHILIPPE 
Published: June 2022

Single toe necrosis complicating DFU requires an amputation performed in the operating room by a surgeon (ORAS) . Bedside amputation by a diabetologist (BAD) complying with the surgical rules might be an option in case of disagreement with the surgeon about the amputation level (major favored by the surgeon) and/or an anesthetic contraindication. In our monocentric, retrospective study, we assessed the one year prognosis (healing rate without extra surgery) of a single toe necrosis amputation over DFU performed by a diabetologist or a surgeon. Amputation levels (transphalangeal, TPA, metatarsophalangeal disarticulation, MPD, single transmetatarsal, TMA) were decided by our multidisciplinary team. Out of 7patients admitted with DFU (05.2016-10.2020) , 57 (8%) were included because of single toe necrosis (BAD n=33, 58%; ORAS n=24, 42%) . Amputation levels TPA, MPD, TMA were respectively 26, 47, 27%. The median duration of follow-up was 28 months. Patients characteristics were non statistically different between groups except for the dorsal arch permeability: males 74%; median age 64y; Type 2 Diabetes Mellitus (DM) 97%; median DM duration 17y. The rate of permeable dorsal arch was significantly lower in the BAD group (45% vs. 75%, p=0.03) . Single TMA rate was significantly higher in the ORAS group (50% vs. 9%, p=0.001) . The one year healing rate without extra surgery was statistically different between the two groups (BAD 58% vs. ORAS 83%, p=0.05) . The need for extra surgery was significantly higher in the BAD group (42% vs. ORAS 13%, p=0.02) . The overall mortality was non significantly different between groups (BAD 21% vs. ORAS 4%, p=0.12) . For a single toe necrosis over DFU, in patients with a high risk for a circumscribed toe amputation failure as stated by the surgeon, the results of bedside amputation performed by a diabetologist invalidated this unfavorable prognosis in most cases.

Disclosure
F.Féron: None. J.Riveline: None. J.Gautier: Other Relationship; Novo Nordisk, Sanofi, Speaker's Bureau; Eli Lilly and Company. J.Kevorkian: None.
1488-PUB: Did New York City Diabetes Prevention Programs Suffer or Succeed during COVID-Pandemic Lockdowns?
Authors: APFELBAUM LEORA , SMITH ELEANOR , HORLYCK-ROMANOVSKY MARGRETHE F. 
Published: June 2022

Pandemic restrictions may have affected in-person health education such as the CDC’s Diabetes Prevention Program (DPP) . We interviewed staff from New York City (NYC) DPPs to a) document if/how DPPs adapted and served participants during pandemic lockdowns, and b) identify successes and challenges to operating remotely. Interviewees were lifestyle coaches and DPP coordinators representing a public hospital, a national weight loss program, a healthcare center, a community based organization, a health insurance company, a faith-based DPP, and a network of federally qualified health centers. DPPs served participants in Manhattan, Brooklyn, Queens, and the Bronx. Zoom interviews (1hr) were recorded and transcribed. Interviewees received a $50 gift card.DPP host organizations continued to provide DPP services during the pandemic and experienced a number of successes and challenges (Table) .
NYC DPPs suffered greatly during COVID-lockdowns and limits on social gathering because they and their participants were unprepared for virtual classes. However, most were successful due to resilient, dedicated, and extraordinarily creative staff. The pandemic highlighted opportunities for successful virtual DPPs in the urban setting, and the need for more robust funding mechanisms, staff support, and technical assistance to ensure sustainability and scalability of the DPP.

Disclosure
L.Apfelbaum: None. E.Smith: None. M.F.Horlyck-romanovsky: None.

Funding
Brooklyn College Faculty startup funds
1489-PUB: Know Diabetes by Heart Campaign and Project Dulce: A Culturally Tailored Mobile-Based Self-Management Program Supports High-Risk Populations with Diabetes to Manage Cardiovascular Disease Risk
Authors: RUIZ MONICA , FORTMANN ADDIE L. , SANDOVAL HALEY , PHILIS-TSIMIKAS ATHENA , CHICHMARENKO MARIYA , BAGSIC SAMANTHA R. , BOYER JOSHUA 
Published: June 2022

Diabetes, high blood pressure, and obesity are major risk factors for cardiovascular disease (CVD) . Access to and awareness of health education programming is often low in ethnic/racial minorities and individuals of low socioeconomic status experience a higher prevalence of T2D, hypertension, CVD and stroke. Additionally, underserved, at-risk patients face barriers to accessing traditional in-person diabetes self-management education and support (DSME/S) due to transportation, caregiving, and work conflicts. To address this gap, the ADA’s Know Diabetes by Heart (KDBH) initiative partnered with Project Dulce, an evidence-based culturally and linguistically modified DSME/S program to overlay an innovative digital approach to diabetes support programming and resources in the community. In response to COVID-restrictions, Project Dulce sessions integrating KDBH content were delivered via telehealth group sessions and text messaging to encourage heart healthy self-management behaviors. Pre/post surveys assessed knowledge and self-management, and clinical metrics were evaluated via electronic health records. The KDBH/Project Dulce DSME/S program was delivered to 5 health systems in California: 2 Federally Qualified Health Centers, 2 County health clinics and 1 large community-based health system near the US/Mexico border. Of the N=553 who received KDBH/Project Dulce education, 47% were White, 36% Hispanic, 14% African American, Asian, Native American, Pacific Islander, and 3% other. Of all enrollees, 58% were female, and 15% were &lt;/= 45 y/o, 50% were 46-65 y/o and 35% were &gt;/= 66 y/o. Participant feedback indicated acceptance of both the group virtual and texting programs. Findings demonstrate the feasibility of disseminating important heart healthy interventions to diverse ethnic/racial minority groups via a variety of digital and telehealth methods.

Disclosure
M.Ruiz: n/a. A.L.Fortmann: Consultant; Ascensia Diabetes Care, Employee; Dexcom, Inc. H.Sandoval: None. A.Philis-tsimikas: Advisory Panel; Bayer AG, Novo Nordisk, Research Support; Lilly Diabetes, National Institute of Diabetes and Digestive and Kidney Diseases, Novo Nordisk, Viking Therapeutics. M.Chichmarenko: None. S.R.Bagsic: None. J.Boyer: None.

Funding
American Diabetes Association/KDBH;