bluuebunny/crossref_metadata_2025_split huggingface dataset:
A minute in time saves minds: Psychosocial Safety Climate (PSC– 4) cut-points for early detection of mental distress
Authors: Dollard Maureen Frances , Bailey Tessa , Owen Mikaela 
Published: March 2022

Abstract
Background Mental health disorders are a major public health issue accounting for 10% of the global burden of disease and are the single largest contributor to global disability. An important social determinant of worker mental health is the corporate climate for psychological health (i.e., Psychosocial Safety Climate, PSC). This study aimed to develop PSC-4 risk levels for predicting job strain and mental ill-health and determine the population attributable risk (PAR) of these criteria to PSC. Method Australian Workplace Barometer survey interviews were used yielding cross-sectional (Time 1, n=2970; Time 2, n=4140) and longitudinal (n=1476) data. PSC-4 risk levels were determined by comparative mean level and ROC analyses. Logistic regression assessed the predictive validity of PSC-4 risk on criteria controlling for baselines and PAR was estimated.Results Workers reported high job strain (jobs combining high demands and low control) (20%), and mild/moderate to severe symptoms of psychological distress (16%), and depression (8%). PSC-4 risk levels were estimated as > 13 low risk and < 12 high risk for job strain and worker mental ill-health. The PAR revealed that eliminating high risk PSC could reduce 22% of the Australian worker population burden of psychological distress, 32% of depressive symptoms, and 12% of job strain.Conclusion This easy-to-use one minute tool could help shift clinical medical thinking to social determinants of mental health, such as the corporate climate. PAR results show large scope for job strain and mental ill-health prevention by improving PSC. Advocacy by public health, psychiatrists, and physicians could bolster social protection for worker mental health.
Non-wilms' Renal Tumors in Children: Experience With 139 Cases Treated at a Single Center
Authors: Fang YiWei , Song HongCheng , Sun Ning , Zhang Wei Ping 
Published: March 2022

Abstract
Introduction: To determine the clinical characteristics, management and prognosis of children with Pediatric non-Wilms renal tumors (NWRTs).Methods: Medical records of all patients (n = 139) treated for NWRTs over a 12-year period (2008.01–2019.10) at a single center were reviewed retrospectively.Results: The histopathological groups of NWRTs included malignant rhabdoid tumor of the kidney (MRTK) (n: 30, 21.6%), renal cell cancer (RCC) (n: 26,18.7%), clear cell sarcoma of the kidney (CCSK) (n: 24,17.3%), congenital mesoblastic nephroma (CMN) (n: 21,15.1%), cystic nephroma (CN) (n: 16,11.5%), metanephric tumors (n: 12, 8.6%), renal angiomyoliporma (RAML) (n: 3, 2.2%), renal primitive neuroectodermal tumor (rPNET) (n: 2, 1.4%), renal hemangioma (n: 2, 1.4%), inflammatory myofibroblastic tumor (IMT) (n: 2, 1.4%), ossifying renal tumor of infancy (ORTI) (n: 1, 0.7%). The distribution of all malignant NWRTs, including MRTK, CCSK, RCC and PNET, according to stage was as follows: stages I (n=26), II (n=16), III (n=29), and IV (n=11). The summary table shows the treatment offered to children with NWRTs. A total of 123 children were followed up for an average of 42 months. Sixteen children were lost to follow-up. Tumor-free survival was observed in 94 children. One patient who suffered from RCC is currently receiving targeted therapy and survives with the tumor. Twenty-eight children (22.8%) died.Discussion: Pediatric NWRTs comprise 19.1% of all renal tumors in our single center. The mainstay treatment of malignant NWRTs, including MRTK, CCSK, RCC and PNET, is comprehensive treatment. The mainstay treatment of benign NWRTs, including RAML, CN, ORTI, CMN, metanephric tumors, and renal hemangioma, is surgical resection alone.
Social Network-based Group Intervention to Promote HIV Prevention in Uganda: Study Protocol for a Randomized Controlled Trial of Game Changers
Authors: Wagner Glenn , Bogart Laura , Green Harold , Storholm Erik , Klein David , McBain Ryan , Serunkuuma Richard , Mubiru Kuraish , Matovu Joseph , Okoboi Stephen 
Published: March 2022

Abstract
IntroductionInnovative strategies are needed to disseminate HIV prevention messages across communities efficiently, as well as reduce HIV stigma while promoting HIV prevention. This randomized controlled trial will evaluate the efficacy of a social network-based group intervention, Game Changers, which trains persons living with HIV (PLWH) to encourage members of their social network to use HIV protective behaviorsMethodsPLWH in HIV care for at least one year will be randomly assigned to receive the 8-session group advocacy training intervention or no-intervention control group. Each enrolled PLWH (index participant) will be asked to recruit up to four social network members (alter participant). Assessments will be administered at baseline and month 6, 12 and 18 to both index and alter participants. The primary outcomes are HIV testing and condom use among alter participants; secondary outcomes are engagement in HIV prevention advocacy and internalized HIV stigma among index participants. Repeated-measures multivariable regression analyses will be conducted to compare outcomes between the intervention and control arms, in addition to a cost-effectiveness evaluation.DiscussionThis social network-based approach to HIV prevention is particularly timely in the era of biomedical interventions, which require widespread penetration of effective HIV prevention and care messaging into communities. Positioning PLWH as central to the solution for controlling (vs. causing) the HIV epidemic has the potential to reduce HIV stigma and improve prevention outcomes at the individual and network levels.Trial RegistrationNIH Clinical Trial Registry NCT05098015 (clinicaltrials.gov; date: 10/18/2021).
The impact of prevention of delayed gastric emptying on long-term prognosis and nutritional status after pancreaticoduodenectomy: a single-center retrospective cohort study
Authors: Iwanaga Naoki , Ito Yuzuru , Miyano Shozo , Machida Michio , Watanobe Ikuo , Sugo Hiroyuki 
Published: March 2022

Abstract
Background
Delayed gastric emptying (DGE) remains an unsolved complication after pancreaticoduodenectomy (PD). The aim of this study was to evaluate the effectiveness of a modified reconstruction technique -anchored straight stomach reconstruction (ASSR) - in reducing the incidence of DGE, and its impact on survival after PD.
Methods
A retrospective analysis of 121 consecutive PD patients was conducted: 100 of them had undergone ASSR and the remaining 21 had undergone conventional modified Child method of reconstruction. The two groups were then compared with regard to the incidence of DGE and long-term outcome including postoperative nutritional status.
Results
The incidence of significant DGE in the ASSR group (5%) was significantly lower than that in the conventional group (29%) (p < 0.001). The 5- and 10-year overall survival rates were significantly better in the ASSR group (60% and 49%, respectively) than in the conventional group (45% and 9%, respectively) (p = 0.024). Multivariate analyses showed that the type of reconstruction (ASSR or conventional) was a significant independent post-PD prognostic factor (p = 0.001). Comparison of nutritional status showed that ASSR facilitated a prompt recovery of body weight (BW) and serum albumin level at 6 months after PD. At 12 months after PD, BW gain was significantly better in the ASSR group than in the conventional group (p = 0.032).
Conclusion
Anchored straight stomach reconstruction is able to reduce the incidence of DGE in patients undergoing PD. The prevention of DGE by ASSR might improve their nutritional status, possibly resulting in a better survival rate after PD.
Safety And Preliminary Efficacy Of Sequential Multiple Ascending Doses Of Solnatide To Treat Pulmonary Permeability Edema In Patients With Moderate To Severe ARDS In A Randomized, Placebo-Controlled, Double-Blind Trial: Preliminary Evaluation Of Safety And Feasibility In Light Of The COVID-19 Pandemic
Authors: Schmid Benedikt , Kranke Peter , Lucas Rudolf , Meybohm Patrick , Zwissler Bernhard , Frank Sandra 
Published: March 2022

Abstract
Background: In May 2018 the first patient was enrolled in the phase-IIb clinical trial “Safety and Preliminary Efficacy of Sequential Multiple Ascending Doses of Solnatide to Treat Pulmonary Permeability Edema in Patients with Moderate to Severe ARDS” With the onset of the COVID-19 pandemic in early 2020, the continuation and successful execution of this clinical study was in danger. Therefore, before the Data Safety Monitoring Board (DSMB) allowed proceeding with the study and enrollment of further COVID-19 ARDS patients into it, additional assessment on possible study bias was considered mandatory. Methods: We conducted an ad hoc interim analysis of 16 patients (5 COVID-19- ARDS patients and 11 with ARDS from different causes) from the phase-IIB clinical trial. We assessed possible differences in clinical characteristics of the ARDS patients and the impact of the pandemic on study execution. Results: COVID-19 patients seemed to be less sick at baseline, which also showed in higher survival rates over the 28-day observation period. Trial specific outcomes regarding pulmonary edema and ventilation parameters did not differ between the groups, nor did more general indicators of (pulmonary) sepsis like oxygenation ratio and required noradrenaline doses. Conclusion: The DSMB and the investigators did not find any evidence that patients suffering from ARDS due to SARS-CoV-2 may be at higher (or generally altered) risk when included in the trial, nor were there indications that those patients might influence the integrity of the study data altogether. For this reason, a continuation of the phase IIB clinical study activities can be justified. Researchers continuing clinical trials during the pandemic should always be aware that the exceptional circumstances may alter study results and therefore adaptations of the study design might be necessary.
High throughput 3D gel-based neural organotypic model for cellular assays with fluorescence biosensors
Authors: Kundu Srikanya , Boutin Molly , Strong Caroline , Voss Ty , Ferrer Marc 
Published: March 2022

Abstract
Three-dimensional (3D) organotypic models that capture native-like physiological features of tissues are being pursued as clinically predictive assays for therapeutics development. A range of 3D neural organotypic models are being developed to mimic brain morphology, physiology, and pathology of neurological disease. Biofabrication of 3D gel-based cellular systems is emerging as a versatile technology to produce spatially and cell-type tailored, physiologically complex and native-like tissue models. Here we produce 3D fibrin gel-based functional neural co-culture models with human iPSC differentiated dopaminergic or glutamatergic neurons and astrocytes. We further introduce genetically encoded fluorescence biosensors for real time functional measurements of intracellular calcium and levels of dopamine and glutamate neurotransmitters, in a high throughput compatible plate format. We use optogenetic activation and pharmacological perturbations to demonstrate that functional responses in 3D fibrin gel neural models are as relevant to be expected from in vivo data, compared to the equivalent 2D neural models.
A novel matrine derivative, WM130, inhibits activation and movement of human hepatic stellate LX-2 cells by targeting cofilin 1
Authors: Xu Yang , Duan Jicheng , Ji Weidan , Liu Chao , Li Xiang , Wu Qiuye , Gao Chunfang , Su Changqing 
Published: March 2022

Abstract
Matrine, one of the active ingredients of Sophora flavescens Ait., has a protective effect in animal models on acute liver injury and liver fibrosis. However, since the protective effects are short-lived, a structural modification of matrine is needed to improve its anti-fibrotic effects. In this study, we obtained a novel matrine derivative, WM130, and explored its anti-fibrotic effects on the human hepatic stellate cell line, LX-2. CCK-8, wound healing, and transwell assays were used to investigate cell proliferation and migration, while 3D mimic study was used to determine the target of WM130. Western blots investigated the levels of α-SMA, cofilin 1, p-cofilin 1, F-actin, PI3K, p-Akt, Akt, and PTEN in LX-2 cells treated with MW130. The results revealed that WM130 can significantly inhibit the proliferation of LX-2 cells at an IC50 of 60 µg/ml. At 30 µg/ml, matrine or WM130 significantly inhibited the migration of LX-2 cells. Moreover, WM130 significantly reduced the expression of α-SMA, cofilin 1, F-actin, PI3K, and p-Akt, and increased PTEN levels. In conclusion, WM130 inhibits the proliferation, activation, and migration of human hepatic stellate LX-2 cells by targeting cofilin 1.
WITHDRAWN: Modulation of CUMS Induced Behaviour Deficits in Rats by Alpha Lipoic Acid: Possible Involvement of Dopaminergic and Serotonergic Neurotransmission
Authors: Akotkar Likhit , Aswar Urmila , Patil Rashmi , Kumar Dileep , Aswar Manoj , Pandey Jyoti 
Published: March 2022

Abstract
Purpose: Stress is an important factor having a high impact on psychological development which alters emotion, cognition and related behavioural outputs. Alpha lipoic acid (ALA) is a potent neuroprotectant and antioxidant; however, it has not been studied in clinically relevant, chronic unpredictable mild stress (CUMS) induced behaviour deficits model in rats as well as its mechanism of action is unclear. Hence, the purpose of this study was to determine its antidepressant activity in CUMS induced depression-like behaviour and to understand its mechanism of action using brain monoamine estimations and molecular docking study.Methods: The Wistar rats were divided into 6 groups. Group I vehicle control (without stress), Group II- CUMS, Group III- fluoxetine (FLX) (50 mg/kg), Group IV, V, and VI were treated with ALA (50, 100, 200 mg/kg, p.o.) respectively. All the groups, except I, were subjected to CUMS along with the treatments which were given orally from day 1 to day 42. The behavioural parameters like sucrose preference test (SPT), Morris water maze (MWM), resident intruder test (RIT), marble-burying test (MBT) were performed on day 0, day 21, and day 42 and forced swim test (FST) on day 42 only. Animals were sacrificed at the end of the study; the brain homogenate was prepared and used for the antioxidant, histopathology and monoamine estimations.Results: When compared with CUMS group, ALA (50, 100, 200) treatment displays improved behavioural parameters, increased GSH, SOD, catalase and reduced MDA, NO. Concentrations of monoamines (5-HT, DA, NE) were also found to be restored in brain homogenate. Histopathological results indicated the protection of CA3 neurons in the hippocampus. Computational molecular docking revealed strong binding of ALA on the 5HT3 receptor. Conclusion: Consequently, the study demonstrates that ALA might be exhibiting antidepressant effects in part by restoring monoamines as well as may be modulating the 5HT3 receptor.
Workload And Workflow Implications Associated With The Use Of Electronic Clinical Decision Support Tools Used By Health Professionals In General Practice: A Scoping Review
Authors: Fletcher Emily , Burns Alex , Wiering Bianca , Lavu Deepthi , Shephard Elizabeth , Hamilton Willie , Campbell John L , Abel Gary 
Published: March 2022

Abstract
Background: Electronic clinical decision support tools (eCDS) are increasingly available to assist General Practitioners (GP) with the diagnosis and management of a range of health conditions. It is unclear whether the use of eCDS tools has an impact on GP workload. This scoping review aimed to identify the available evidence on the use of eCDS tools by health professionals in general practice in relation to their impact on workload and workflow.Methods: A scoping review was carried out using the Arksey and O’Malley methodological framework. The search strategy was developed iteratively, with three main aspects: general practice/primary care contexts, risk assessment/decision support tools, and workload-related factors. Three databases were searched in 2019, and updated in 2021, covering articles published since 2009: Medline (Ovid), HMIC (Ovid) and Web of Science (TR). Double screening was completed by two reviewers, and data extracted from included articles were analysed.Results: The search resulted in 5,594 references, leading to 91 full articles after screening. Of these, 33 studies were based in the USA, 20 in the UK and 11 in Australia. A further 22 originated from Canada or Europe, with the remaining studies conducted in New Zealand, South Africa and Malaysia. Studies examined the use of eCDS tools and reported some findings related to their impact on workload, including on consultation duration. Most studies were qualitative and exploratory in nature, reporting health professionals’ subjective perceptions of consultation duration as opposed to objectively-measured time spent using tools or consultation durations. Other workload-related findings included impacts on cognitive workload, “workflow” and dialogue with patients, and clinicians’ experience of “alert fatigue”.Conclusions: The published literature on the impact of eCDS tools in general practice showed that limited efforts have focused on investigating the impact of such tools on workload and workflow. To gain an understanding of this area, further research, including quantitative measurement of consultation durations, would be useful to inform the future design and implementation of eCDS tools.
Urban and Rural Environmental Management Strategy Based on the Cause of Bird Death Investigation: The Context of Wumeng Mountainous Area
Authors: zhu xiongbin , Bo Dong , Chen Xiaoqiao 
Published: March 2022

Abstract
With the continuous deterioration of the ecological environment in the Wumeng mountain area, the number of birds has gradually decreased in recent years. To find out the cause of bird death, the author team up with many bird lovers and zoologists to collect bird corpses in the Wumeng Mountain area with large topographic changes and rich geomorphic types from 2018 to 2020 in this area. With anatomical analysis and pathogen detection, the main findings include: (1) The number of bird deaths has not increased due to the extreme high temperature in 2020 in Wumeng mountainous area. (2) The main causes of bird deaths are pesticide, rodenticide and birds-building collision. (3)Most birds died in summer and winter, which are mainly poisoned by insecticide in summer and killed by glass impact and Rodenticide in winter. (4)The dead birds are mainly local dominant species(sparrows, white babblers, great tits and Northern Redstart). From the findings, we can infer that the main cause of bird death has little to do with weather changes and avian influenza virus in Wumeng Mountain area, but closely related to human agricultural production and construction activities. Accordingly, we put forward some suggestions and Strategies of urban and rural spatial environment management, hoping to provide reference for urban and rural ecological construction and bird protection in Wumeng Mountain area.
CoVID-19 Pandemic consequences on emergency surgery: an observational case-control study from an Italian tertiary referral hospital
Authors: Pirozzolo Giovanni , Bao Quoc Riccardo , Baiano Livio , D’Alimonte Lucrezia , Vignotto Chiara , Piangerelli Alfredo , Peluso Claudia , Cimino Fabrizio Giuseppe Maria , Meneghetti Guido , Grassetto Alberto , Rizzo Maurizio , Scarpa Marco , Recordare Alfonso Giovanni 
Published: March 2022

Abstract
Background In 2020, on March the 9th, the Italian Prime Minister announced the lockdown, which was officially closed on May the 4th. This extraordinary measure was necessary to contain the CoVID-19 pandemic spread in Italy. During this phase, a significant decrease of patient’s access to Emergency Department (ED) was observed. Delayed access to treatment may have led to a delay in the diagnosis of acute conditions also in the surgical field, as already documented in other areas, with consequences on surgical outcome and survival.Aim of this study is to provide a detailed description of abdominal urgent-emergent conditions surgically treated and surgical outcomes during the lockdown in a tertiary referral Italian hospital, compared with historical data.MethodsA retrospective review of urgent-emergent patients surgically treated in our department was conducted in order to compare patients’ characteristics and surgical outcomes during the period March 9th - May 4th 2020 with the same period of the previous year. Results152 patients were included in our study, 79 patients in 2020 group and 77 patients in 2019. We found no significant differences between the groups about ASA score, age, gender and disease prevalence. Significant differences were found about symptoms duration before ER access and abdominal pain as main symptom in non-traumatic conditions. We also performed a sub-analysis on peritonitis which showed significant differences in: hospital length of stay, presence of colostomy vs ileostomy and fatal events in 2020. No differences were found in the use of laparoscopy. ConclusionsWhile the overall number of ER accesses has decreased in 2020 group, the number of patients surgically treated in emergency-urgency conditions has not decreased. However, those patients waited significantly more before the hospital access. This diagnostic delay was associated to a more severe clinical condition and a consequent significantly worse prognosis.
An Enhanced Beetle Antennae Search Algorithm Based Comprehensive Water Quality Index for Urban River Water Quality Assessment
Authors: Gao Zehai , Liu Yang , Li Nan , Ma Kangjie 
Published: March 2022

Abstract
Urban river not only has the important function in urban hydrological environment, but also is an area for entertainment. Water quality assessment is the core technique in water resource management. As the typical urban river, water samples were collected at 5 sampling points in Xi’an moat from January 2018 to December 2020, and 10 physicochemical parameters were analyzed. In this paper, a comprehensive water quality index (WQI) is designed based on the criterion of water quality classes and entropy weight method firstly. Secondly, the crucial water quality parameters is determined by using mutual information, coefficient of variation and the water quality classes. Finally, an enhanced beetle antennae search algorithm is proposed to optimize the weight values of the crucial parameters in the range 0 to 1, which represent the ratio of the crucial parameter in the minimum WQI (WQImin) model. The WQImin models with the various crucial water quality parameters are implemented for water quality assessment. The effectiveness and superiority of the proposed enhanced beetle antennae search algorithm are validated in comparison with other evolutionary algorithms. The results show that the proposed WQImin model can assess the water quality accurately.