bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying the indicator amino acid oxidation technique in the domestic cat: results of a pilot study and development of a non-steady state prediction model
Authors: Pezzali Julia Guazzelli , Rafii Mahroukh , Courtney-Martin Glenda , Cant John P , Shoveller Anna K 
Published: November 2022

AbstractThe aim of this study was to evaluate whether the indicator amino acid oxidation (IAAO) method could be applied in the domestic cat. Six adult male cats were used in a replicated 3 × 3 Latin square design. Three semi-synthetic diets were developed: a methionine (Met) and total sulfur AA (TSAA) deficient diet (T-BASAL; 0.24% Met+Cys − DM basis) and two Met and TSAA-sufficient diets in which either dl-Met (T-DLM) or 2-hydroxy-4-(methylthio)-butanoic acid (T-MHA) were supplemented, respectively, on an equimolar basis to meet the TSAA requirement (0.34%). After a 2-d diet adaptation, IAAO studies were performed. Cats were offered 13 small meals. The sixth meal contained a priming dose (4.8 mg/kg-BW) of l-[1-13C]-Phe and the remaining meals a constant dose (1.04 mg/kg-BW). Breath samples were collected every 25 min to measure 13CO2 enrichment. The following morning, fasted blood samples were collected. Cats returned to the T-BASAL top dressed with a dl-Met solution for 4 d prior to being fed a new dietary treatment. Isotopic steady state was evaluated through visual inspection. Data were analyzed using PROC GLIMMIX procedure in SAS 9.4. While 13CO2 enrichment was successfully captured in breath samples, cats failed to reach 13CO2 steady state. Thus, a non-steady state isotope model was developed and coded in ACSLX (V3.1.4.2) individually for each cat on each study day to predict 13CO2 enrichment, and then, calculate oxidation of l-[1-13C]-Phe (F13CO2). A higher predicted F13CO2 was observed for cats fed T-BASAL compared to the others (P &lt; 0.05), while no differences were observed between T-DLM and T-MHA (P &gt; 0.05). Cats fed T-DLM tended to have higher plasma Met concentrations compared to those fed T-BASAL with cats fed T-MHA intermediate (P = 0.0867). Plasma homocysteine concentrations were higher in cats fed T-BASAL compared to the others (P &lt; 0.05), while threonine concentrations tended to be higher in cats fed T-BASAL compared to those fed T-MHA (P = 0.0750). In conclusion, short-term provision of a semi-synthetic diet deficient in Met may elicit a metabolic response aiming to conserve Met. The successful quantification of 13CO2 enrichment in breath and the higher predicted F13CO2 in cats fed a Met deficient diet suggest that the IAAO technique may be used in cats. Adaptations in the isotope protocol should be made to achieve 13CO2 steady state in breath and avoid mathematical modeling to predict F13CO2.
Surf4, cargo trafficking, lipid metabolism, and therapeutic implications
Authors: Shen Yishi , Gu Hong-Mei , Qin Shucun , Zhang Da-Wei 
Published: November 2022

ABSTRACTSurfeit 4 is a polytopic transmembrane protein that primarily resides in the endoplasmic reticulum (ER) membrane. It is ubiquitously expressed and functions as a cargo receptor, mediating cargo transport from the ER to the Golgi apparatus via the canonical coat protein complex II (COPII)-coated vesicles or specific vesicles. It also participates in ER–Golgi protein trafficking through a tubular network. Meanwhile, it facilitates retrograde transportation of cargos from the Golgi apparatus to the ER through COPI-coated vesicles. Surf4 can selectively mediate export of diverse cargos, such as PCSK9 very low-density lipoprotein (VLDL), progranulin, α1-antitrypsin, STING, proinsulin, and erythropoietin. It has been implicated in facilitating VLDL secretion, promoting cell proliferation and migration, and increasing replication of positive-strand RNA viruses. Therefore, Surf4 plays a crucial role in various physiological and pathophysiological processes and emerges as a promising therapeutic target. However, the molecular mechanisms by which Surf4 selectively sorts diverse cargos for ER–Golgi protein trafficking remain elusive. Here, we summarize the most recent advances in Surf4, focusing on its role in lipid metabolism.
Regulatory Convergence Between U.S. Antitrust Law and Eu Competition Law in International Air Transport—Taking Stock
Authors: Lykotrafiti Antigoni 
Published: November 2022

Abstract
This article takes stock of the regulatory convergence between US antitrust law and EU competition law in the field of international air transport. The analysis draws a distinction between domestic aviation and international aviation and sets the boundaries of regulatory convergence in international air transportation. Through a comparative analysis of the decisional practice of the U.S. Department of Transportation and the European Commission, it identifies instances of regulatory convergence in: (i) the definition of the relevant market in international airline alliance cases, (ii) the remedies imposed to immunize international airline alliances, and (iii) the duration of the antitrust immunity. It further identifies an instance of legislative convergence in the area of fair competition in international air transport. The analysis addresses the future of regulatory convergence in the post-Covid 19 era and emphasizes the role of the competition authorities in safeguarding consumer welfare.
Multiscale computational solid mechanics: data and machine learning
Authors: Su Tung-Huan , Huang Szu-Jui , Jean Jimmy Gaspard , Chen Chuin-Shan 
Published: November 2022

Abstract
Multiscale computational solid mechanics concurrently connects complex material physics and macroscopic structural analysis to accelerate the application of advanced materials in the industry rather than resorting to empirical constitutive models. The rise of data-driven multiscale material modeling opens a major paradigm shift in multiscale computational solid mechanics in the era of material big data. This paper reviews state-of-the-art data-driven methods for multiscale simulation, focusing on data-driven multiscale finite element method (data-driven FE2) and data-driven multiscale finite element-deep material network method (data-driven FE-DMN). Both types of data-driven multiscale methods aim to resolve the past challenge of concurrent multiscale simulation. Numerical examples are designed to demonstrate the effectiveness of data-driven multiscale simulation methods. Future research directions are discussed, including data sampling strategy and data generation technique for the data-driven FE2 method and generalization of data-driven FE-DMN method.
Impacts of methyl jasmonate onSelaginella martensii: volatiles, transcriptomics, phytohormones, and gas exchange
Authors: Wuyun Tana , Hõrak Hanna , Liu Bin , Talts Eero , Kilk Kalle , Kaurilind Eve , Li Caihong , Zhang Lu , Niinemets Ülo 
Published: November 2022

AbstractMethyl jasmonate (MeJA) induces various defence responses in seed plants, but for early plant lineages, information on the potential of jasmonates to elicit stress signalling and trigger physiological modifications is limited. The spikemoss Selaginella martensii was exposed to a range of MeJA concentrations (0, 10, 25, and 50 mM), and biogenic volatile organic compound (BVOC) emissions, photosynthetic rate (A), and stomatal conductance (gs) were continuously measured. In addition, changes in phytohormone concentrations and gene expression were studied. Enhancement of methanol, lipoxygenase pathway volatiles and linalool emissions, and reductions in A and gs, were MeJA dose-dependent. Before MeJA treatment, the concentration of 12-oxo-phytodienoic acid (OPDA) was 7-fold higher than jasmonic acid (JA). MeJA treatment rapidly increased OPDA and JA concentrations (within 30 min), with the latter more responsive. Some genes involved in BVOC biosynthesis and OPDA-specific response were up-regulated at 30 min after MeJA spraying, whereas those in the JA signalling pathway were not affected. Although JA was synthesized in S. martensii, OPDA was prioritized as a signalling molecule upon MeJA application. MeJA inhibited primary and enhanced secondary metabolism; we propose that fast-emitted linalool could serve as a marker of elicitation of stress-induced metabolism in lycophytes.
Stable ARMADILLO REPEAT KINESIN 2 in light inhibits hypocotyl elongation and facilitates light-induced cortical microtubule reorientation in Arabidopsis
Authors: Lan Miao , Kang Erfang , Liu Xianan , Fu Ying , Zhu Lei 
Published: November 2022

AbstractHypocotyls undergo different morphogenesis in light and dark conditions, with cortical microtubules being reoriented in response to light to coordinate cell growth status. Kinesins are microtubule-based motor proteins that are mostly responsible for transporting organelles and vesicles, although some can also regulate microtubule organization; however, it is currently not known whether they are involved in microtubule reorientation and hypocotyl elongation. In this study, we found that ARMADILLO REPEAT KINESIN 2 (ARK2) negatively regulated the hypocotyl elongation of Arabidopsis. The hypocotyl cells of plants with the ark2 null allele were longer than those of the wild type and had relatively more transversely arranged cortical microtubules. In addition, ARK2 co-localized with cortical microtubules and facilitated the light-induced reorientation of the cortical microtubule arrays. Interestingly, the ARK2 protein is stable in the light and degraded through the 26S proteasome pathway in the dark. Furthermore, we determined that ARK2 could interact with the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), which contributed to down-regulation of ARK2 in darkness that might benefit hypocotyl growth in the dark.
A Qualitative Study of the Expectations, Experiences, and Perceptions That Underpin Decisions Regarding PTSD Treatment in Help-seeking Veterans
Authors: Hinton Mark , Metcalf Olivia , Varker Tracey , Roebuck Greg , McGaw Violette , Watson Loretta , Fredrickson Julia , Johnson Lucinda , Forbes David , Phelps Andrea , Kartal Dzenana , Dell Lisa , Bryant Richard , McFarlane Alexander C , Hopwood Malcolm , O’Donnell Meaghan 
Published: November 2022

ABSTRACT

Introduction
A range of evidence-based treatments are available for PTSD. However, many veterans with PTSD do not engage in these treatments. Concurrently, various novel PTSD treatments with little or no evidence based are increasingly popular among veterans. This qualitative study explored the expectations, experiences, and perceptions of help-seeking veterans with PTSD to improve understanding of how these veterans make treatment decisions.

Materials and Methods
Fifteen treatment-seeking veterans with PTSD participated in the study. Participants took part in semi-structured interviews. Data were analyzed using interpretative phenomenological analysis.

Results
A number of themes and subthemes emerged from the data, providing a detailed account of the factors that influenced participants’ treatment decisions. Most participants were in an acute crisis when they made the initial decision to seek treatment for their PTSD. In choosing a specific treatment, they tended to follow recommendations made by other veterans or health professionals or orders or directions from their superiors, health providers, or employers. Few participants actively considered the scientific evidence supporting different treatments. Participants had a strong preference for treatment provided by or involving other veterans. They reported finding PTSD treatments helpful, although some were not convinced of the value of evidence-based treatments specifically. Many participants reported negative experiences with treatment providers.

Conclusions
These findings will inform strategies to improve engagement of veterans in evidence-based PTSD treatments and advance progress toward veteran-centered care.
First polarimetric evidence of the existence of the Kordylewski Dust Cloud at the L4 Lagrange point of the Earth–Moon system
Authors: Slíz-Balogh Judit , Mádai Attila , Sári Pál , Barta András , Horváth Gábor 
Published: November 2022

ABSTRACT
In 1961, Kordylewski found two bright patches near the L5 Lagrange point of the Earth–Moon system. This referred to an accumulation of dust particles, later called as Kordylewski dust cloud (KDC). In spite of the photographic observation of the L5 KDC by Kordylewski and its visual (naked-eyed) or photometric confirmation by others, some astronomers assumed that the KDC cannot exist, because the gravitational perturbation of the Sun may disrupt the stabilizing effect of the triangular Lagrange points L4 and L5 of the Earth and Moon. In 2017, the L5 KDC was observed in two consecutive nights by ground-based imaging polarimetry. So far the L5 KDC has been detected 16 times and the L4 KDC only 5 times. Contrary to the visually, photometrically, and polarimetrically documented existence of the L5 KDC, a polarimetric proof does not exist for the L4 KDC. On 2022 July 3, we were able to detect the polarization signals of the L4 KDC, furthermore on 2021 October 31 we detected polarimetrically again the L5 KDC. In this work, we present the first polarimetric evidence of the existence of the L4 KDC, and corroborate polarimetrically the existence of the L5 KDC for the third time.
Gravitational waves from the propagation of long gamma-ray burst jets
Authors: Urrutia Gerardo , De Colle Fabio , Moreno Claudia , Zanolin Michele 
Published: November 2022

ABSTRACT
Gamma-ray bursts (GRBs) are produced during the propagation of ultra-relativistic jets. It is challenging to study the jet close to the central source, due to the high opacity of the medium. In this paper, we present numerical simulations of relativistic jets propagating through a massive, stripped envelope star associated to long GRBs, breaking out of the star and accelerating into the circumstellar medium. We compute the gravitational wave (GW) signal resulting from the propagation of the jet through the star and the circumstellar medium. We show that key parameters of the jet propagation can be directly determined by the GW signal. The signal presents a first peak corresponding to the jet duration and a second peak which corresponds to the break-out time for an observer located close to the jet axis (which in turn depends on the stellar size), or to much larger times (corresponding to the end of the acceleration phase) for off-axis observers. We also show that the slope of the GW signal before and around the first peak tracks the jet luminosity history and the structure of the progenitor star. The amplitude of the GW signal is h+D ∼ hundreds to several thousands cm. Although this signal, for extragalactic sources, is outside the range of detectability of current GW detectors, it can be detected by future instruments as BBO, DECIGO, and ALIA. Our results illustrate that future detections of GW associated to GRB jets may represent a revolution in our understanding of this phenomenon.
An update on Fermi-LAT transients in the Galactic plane, including strong activity of Cygnus X-3 in mid-2020
Authors: Prokhorov D A , Moraghan A 
Published: November 2022

ABSTRACT
We present a search for Galactic transient γ-ray sources using 13 yr of the Fermi Large Area Telescope data. The search is based on a recently developed variable-size sliding-time-window (VSSTW) analysis and aimed at studying variable γ-ray emission from binary systems, including novae, γ-ray binaries, and microquasars. Compared to the previous search for transient sources at random positions in the sky with 11.5 yr of data, we included γ-rays with energies down to 500 MeV, increased a number of test positions, and extended the data set by adding data collected between 2020 February and 2021 July. These refinements allowed us to detect additional three novae, V1324 Sco, V5855 Sgr, V357 Mus, and one γ-ray binary, PSR B1259-63, with the VSSTW method. Our search revealed a γ-ray flare from the microquasar, Cygnus X-3, occurred in 2020. When applied to equal quarters of the data, the analysis provided us with detections of repeating signals from PSR B1259-63, LS I +61°303, PSR J2021+4026, and Cygnus X-3. While the Cygnus X-3 was bright in γ-rays in mid-2020, it was in a soft X-ray state and we found that its γ-ray emission was modulated with the orbital period.
Destruction of phosphorus nitride through the N(4S) + PN(1Σ+) → N2(1Σ+) + P(4S) reaction
Authors: Gomes Alexandre C R , Spada Rene F K , Lefloch Bertrand , Galvão Breno R L 
Published: November 2022

ABSTRACT
The study of reactions involving phosphorus bearing species (PBS) in star-forming regions as well as in circumstellar envelopes are important to elucidate the mechanisms in which this element is formed and destroyed, and perhaps, lead to important pre-biotic molecules. Phosphorus nitride (PN) is the most easily detected PBS in the interstellar medium (ISM), and is considered as one of the major reservoirs of this element in the ISM. However, only a few of its reactions have been analysed experimentally or computationally. Therefore, modelling PN chemistry and interpretation of the observations suffer uncertainties, affecting our astrochemical understanding of this species. In this work, we perform explicitly correlated multireference configuration interaction (MRCI+Q/AVTZ+d//CAS/AVTZ+d) calculations on the destruction of PN through the N(4S) + PN(1Σ+) reaction. We have also performed DFT (M06-2X) and CCSD(T) calculations for benchmark purposes. Rate coefficients over a large range of temperatures were computed using standard transition state theory (TST), canonical variational TST (CVT), and also incorporating tunneling effects with the small curvature tunneling method (SCT). We found that the NPN system possesses a considerable multireference character, and the DFT approach cannot properly describe the available destruction mechanisms. Our best estimate for the rate coefficients, at the MRCI+Q/AVTZ+d level, can be described by the modified Arrhenius equation 1.09×10−11(T/300)−1.02exp (− 7919/T). We show for the first time that this reaction may be considerably fast in shock regions and in high temperature environments of solar-type star forming regions, and of significant importance to model the abundance of PN in such environments.
Impact of non-thermal electron radiation effects on the horizon scale image structure of Sagittarius A∗
Authors: Zhao Shan-Shan , Huang Lei , Lu Ru-Sen , Shen Zhiqiang 
Published: November 2022

ABSTRACT
The Event Horizon Telescope (EHT), with ∼20 $\mu$ as high angular resolution, recently resolved the millimetre image of the suppermassive black hole in the Galaxy, Sagittarius A∗. This opens a new window to study the plasma on horizon scales. The accreting disc probably contains a small fraction of non-thermal electrons and their emissions should contribute to the observed image. We study if such contributions are sufficient to cause structural differences detectable by current and future observational capabilities. We introduce non-thermal electrons in a semi-analytical accretion disc, which considers viscosity-leading heating processes, and adopt a continued hybrid electron energy distribution of thermal distribution and power-law tail. We generate the black hole images and extract the structural features as crescent parameters. We find the existence of non-thermal electron radiation makes the crescent much brighter, slightly larger, moderately thicker, and much more symmetric. When the non-thermal connecting Lorentz factor γc = 65, which is equivalent to the non-thermal electrons accounting for ∼1.5 per cent of the totals, non-thermal effects cause ∼2 per cent size difference at 230 GHz. Comparing with the structural changes caused by other physical factors, including inclination between the system and the observer, black hole spin, and interstellar medium scattering effects, we find that although non-thermal electron radiation takes the most unimportant role at 230 GHz, it becomes more significant at 345 GHz.
King Ghidorah Supercluster: Mapping the light and dark matter in a new supercluster at z = 0.55 using the subaru hyper suprime-cam
Authors: Shimakawa Rhythm , Okabe Nobuhiro , Shirasaki Masato , Tanaka Masayuki 
Published: November 2022

ABSTRACT
This paper reports our discovery of the most massive supercluster, termed the King Ghidorah Supercluster (KGSc), at z = 0.50–0.64 in the Third Public Data Release of the Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP PDR3) over 690 deg2, as well as an initial result for a galaxy and dark matter mapping. The primary structure of the KGSc comprises triple broad weak-lensing (WL) peaks over 70 comoving Mpc. Such extensive WL detection at z &gt; 0.5 can only currently be achieved using the wide-field high-quality images produced by the HSC-SSP. The structure is also contiguous with multiple large-scale structures across a ∼400 comoving Mpc scale. The entire field has a notable overdensity (δ = 14.7 ± 4.5) of red-sequence clusters. Additionally, large-scale underdensities can be found in the foreground along the line of sight. We confirmed the overdensities in stellar mass and dark matter distributions to be tightly coupled and estimated the total mass of the main structure to be 1 × 1016 solar masses, according to the mock data analyses based on large-volume cosmological simulations. Further, upcoming wide-field multi-object spectrographs such as the Subaru Prime Focus Spectrograph may aid in providing additional insights into distant superclusters beyond the 100 Mpc scale.
Response to Capmatinib in a MET Fusion-positive Cholangiocarcinoma
Authors: Turpin Anthony , Descarpentries Clotilde , Grégoire Valérie , Farchi Olivier , Cortot Alexis B , Jamme Philippe 
Published: November 2022

Abstract
Cholangiocarcinoma is the second most common liver cancer after hepatocellular carcinoma. In case of metastatic or unresectable disease, the recommended first-line treatment is gemcitabine-based doublet, most commonly gemcitabine and cisplatin. There is no standard treatment for further lines. MET fusions are rare alterations described in many cancers. The efficacy of specific MET inhibitors is poorly studied. We present the case of a patient with chemotherapy-refractory metastatic cholangiocarcinoma harboring a CAPZA-2-MET fusion along with MET amplification who dramatically responded to capmatinib, a specific MET tyrosine kinase inhibitor.
Bubbles spray aerosols: Certitudes and mysteries
Authors: Villermaux Emmanuel , Wang Xiaofei , Deike Luc 
Published: November 2022

AbstractOcean spray aerosol formed by bubble bursting are at the core of a broad range of atmospheric processes: they are efficient cloud condensation nuclei and carry a variety of chemical, biological, and biomass material from the surface of the ocean to the atmosphere. The origin and composition of these aerosols is sensibly controlled by the detailed fluid mechanics of bubble bursting. This perspective summarizes our present-day knowledge on how bursting bubbles at the surface of a liquid pool contribute to its fragmentation, namely to the formation of droplets stripped from the pool, and associated mechanisms. In particular, we describe bounds and yields for each distinct mechanism, and the way they are sensitive to the bubble production and environmental conditions. We also underline the consequences of each mechanism on some of the many air-sea interactions phenomena identified to date. Attention is specifically payed at delimiting the known from the unknown and the certitudes from the speculations.