bluuebunny/crossref_metadata_2025_split huggingface dataset:
“I am Kichwa”: The Funds of Identity of an Indigenous Ecuadoran NNES Teacher
Authors: Cappaert Gail B. , Wickens Corrine M. 
Published: June 2022

AbstractTo counter ongoing NES/NNES, NEST/NNEST dichotomies and the essentializing of NNESs (Ellis, 2016), we examine the personal and professional tensions of an Indigenous Ecuadoran NNES teaching in a dominant Spanish‐speaking context. We attend to the ways Roberto (pseudonym) responds to his students and his peers through the lens of his Kichwa identity, the historic oppressed positionality of and ongoing prejudice toward Indigenous peoples in Ecuador. In such contexts, Roberto cannot share “insider” cultural references to enhance his EFL instruction; rather, he is perpetually set as an outsider—both in the broader frame of NNES movement and more singularly and powerfully within his own professional context. We draw upon Esteban‐Guitart and Moll's (2014) “funds of identity” and teacher professional identity development (Sachs, 2005) to explore the following central tensions in Roberto's evolving professional teaching identity: (1) Roberto's sense of himself as (il)legitimate speaker of English, (2) role of structural oppression toward Kichwa as it mediates his perceptions and interactions, and (3) the increased use of communicative‐based language instruction. Attending to the multiple facets and resources that comprise “funds of identity,” EFL teacher educators can better account for the complex identity formation for EFL teachers and students.
Hypersaline spray increases habitat heterogeneity and nesting density in an island‐nesting seabird
Authors: Craig Elizabeth C. , Moore Gregg E. , Seavey Jennifer R. 
Published: June 2022

AbstractSeabirds introduce aquatically‐derived nutrients into their terrestrial nesting environments, often leading to vegetative overgrowth that degrades nesting habitat suitability over time. In this study we capitalized upon the process of salt suppression that naturally occurs in salt‐spray plant communities in order to reintroduce habitat heterogeneity (the mix of open substrate and plant cover) on a common tern (Sterna hirundo) breeding colony in the Gulf of Maine. In 2019, we randomly assigned hypersaline spray and control treatments within 10 experimental blocks across the site, and recorded plant community and seabird reproductive responses. We compared the habitat heterogeneity resulting from salt treatment to estimates of optimal habitat heterogeneity measured within productivity monitoring areas at this site during 2016–2020. We observed an average reduction of approximately 24% plant cover in hypersaline plots relative to control plots (t18 = −5.56, p < 0.001), constituting a substantial increase in nesting habitat heterogeneity. Common tern nesting density was 80% higher in treatment plots relative to controls (t18 = 2.6, P = 0.020), yielding 88% more chicks hatched per square meter (t18 = 3.3, P = 0.004). We suggest that the application of hypersaline spray may serve as an effective and practical habitat management technique in management‐dependent systems such as tern nesting colonies.
Evaluating unmarked abundance estimators using remote cameras and aerial surveys
Authors: Leo Brian T. 
Published: June 2022

AbstractReliable population abundance estimates are invaluable to wildlife management programs. Mark‐recapture techniques are regarded as the gold standard for estimating abundance but can be financially or logistically prohibitive. Recent developments in remote camera analytical approaches have provided alternative methods to estimate unmarked populations efficiently but have undergone limited field testing. In September and October 2020, I assessed 2 camera methods that use the same set of time‐lapse photographs; a space to event (STE) model and instantaneous sampling (IS), applied to a case study of feral sheep (Ovis aries) at the US Army's Pōhakuloa Training Area (PTA) on Hawai`i Island. Results of the camera methods were compared to an abundance estimate calculated from an aerial distance sampling survey completed concurrently with camera sampling. A comparison of confidence intervals indicated no statistical difference between estimates, but the relative imprecision of IS suggested the STE model to be a more reliable estimator. The cost of camera sampling was approximately 3 times that of the aerial survey, but camera sampling became more economical if the area was resurveyed 3 or more times. My study showed the STE model to be a cost effective, practical abundance estimator of feral sheep when compared to well‐established aerial distance sampling techniques, and therefore should offer considerable potential for the conservation and management of other easily identifiable species.
Moscow Rules: A Quantitative Exposé
Authors: Miranda Eduardo 
Published: June 2022

AbstractThis article analyzes the performance of the MoSCoW method to deliver all features in each of its categories: Must Have, Should Have and Could Have using Monte Carlo simulation. The analysis shows that under MoSCoW rules, a team ought to be able to deliver all Must Have features for underestimations of up to 100% with very high probability. The conclusions reached are important for developers as well as for project sponsors to know how much faith to put on any commitments made.
Human Rights Impact Assessment and AI
Authors: Mantelero Alessandro 
Published: June 2022

AbstractThe recent turn in the debate on AI regulation from ethics to law, the wide application of AI and the new challenges it poses in a variety of fields of human activities are urging legislators to find a paradigm of reference to assess the impacts of AI and to guide its development. This cannot only be done at a general level, on the basis of guiding principles and provisions, but the paradigm must be embedded into the development and deployment of each application. To this end, this chapter suggests a model for human rights impact assessment (HRIA) as part of the broader HRESIA model. This is a response to the lack of a formal methodology to facilitate an ex-ante approach based on a human-oriented design of AI. The result is a tool that can be easily used by entities involved in AI development from the outset in the design of new AI solutions and can follow the product/service throughout its lifecycle, providing specific, measurable and comparable evidence on potential impacts, their probability, extension, and severity, and facilitating comparison between possible alternative options.
Identification of genetic loci in lettuce mediating quantitative resistance to fungal pathogens
Authors: Pink Harry , Talbot Adam , Graceson Abi , Graham Juliane , Higgins Gill , Taylor Andrew , Jackson Alison C. , Truco Maria , Michelmore Richard , Yao Chenyi , Gawthrop Frances , Pink David , Hand Paul , Clarkson John P. , Denby Katherine 
Published: June 2022

Abstract

Key message

We demonstrate genetic variation for quantitative resistance against important fungal pathogens in lettuce and its wild relatives, map loci conferring resistance and predict key molecular mechanisms using transcriptome profiling.

Abstract
Lactuca sativa L. (lettuce) is an important leafy vegetable crop grown and consumed globally. Chemicals are routinely used to control major pathogens, including the causal agents of grey mould (Botrytis cinerea) and lettuce drop (Sclerotinia sclerotiorum). With increasing prevalence of pathogen resistance to fungicides and environmental concerns, there is an urgent need to identify sources of genetic resistance to B. cinerea and S. sclerotiorum in lettuce. We demonstrated genetic variation for quantitative resistance to B. cinerea and S. sclerotiorum in a set of 97 diverse lettuce and wild relative accessions, and between the parents of lettuce mapping populations. Transcriptome profiling across multiple lettuce accessions enabled us to identify genes with expression correlated with resistance, predicting the importance of post-transcriptional gene regulation in the lettuce defence response. We identified five genetic loci influencing quantitative resistance in a F6 mapping population derived from a Lactuca serriola (wild relative) × lettuce cross, which each explained 5–10% of the variation. Differential gene expression analysis between the parent lines, and integration of data on correlation of gene expression and resistance in the diversity set, highlighted potential causal genes underlying the quantitative trait loci.
Exposure of intestinal explants to NX, but not to DON, enriches the secretome in mitochondrial proteins
Authors: Soler Laura , Miller Ingrid , Terciolo Chloé , Hummel Karin , Nöbauer Katharina , Neves Manon , Oswald Isabelle P. 
Published: June 2022

AbstractNX is a type A trichothecene produced by Fusarium graminearum with limited information on its toxicity. NX is structurally similar to deoxynivalenol (DON), only differing by the lacking keto group at C8. Because of the structural similarity of the two toxins as well as their potential co-occurrence in food and feed, it is of interest to determine the toxicity of this new compound. In this study, we compared the protein composition of the extracellular media of pig intestinal explants (secretome) exposed to 10 µM of DON or NX for 4 h compared with controls. The combination of two complementary quantitative proteomic approaches (a gel-based and a gel-free approach) identified 18 and 23 differentially abundant proteins (DAPs) for DON and NX, respectively, compared to controls. Functional analysis suggested that, whereas DON toxicity was associated with decreased cell viability and cell destruction, NX toxicity was associated with an enrichment of mitochondrial proteins in the secretome. The presence of these proteins may be associated with the already known ability of NX to induce an intestinal inflammation. Overall, our results indicated that DON- and NX-induced changes in the extracellular proteome of intestinal explants are different. The increased leakage/secretion of mitochondrial proteins by NX may be a feature of NX toxicity.
Large-stepsize integrators for charged-particle dynamics over multiple time scales
Authors: Hairer Ernst , Lubich Christian , Shi Yanyan 
Published: June 2022

AbstractThe Boris algorithm, a closely related variational integrator and a newly proposed filtered variational integrator are studied when they are used to numerically integrate the equations of motion of a charged particle in a mildly non-uniform strong magnetic field, taking step sizes that are much larger than the period of the Larmor rotations. For the Boris algorithm and the standard (unfiltered) variational integrator, satisfactory behaviour is only obtained when the component of the initial velocity orthogonal to the magnetic field is filtered out. The particle motion shows varying behaviour over multiple time scales: fast gyrorotation, guiding centre motion, slow perpendicular drift, near-conservation of the magnetic moment over very long times and conservation of energy for all times. Using modulated Fourier expansions of the exact and numerical solutions, it is analysed to which extent this behaviour is reproduced by the three numerical integrators used with large step sizes that do not resolve the fast gyrorotations.
Correlation of somatostatin receptor PET/CT imaging features and immunohistochemistry in neuroendocrine tumors of the lung: a retrospective observational study
Authors: Rufini Vittoria , Lorusso Margherita , Inzani Frediano , Pasciuto Tina , Triumbari Elizabeth Katherine Anna , Grillo Lucia Rosalba , Locco Filippo , Margaritora Stefano , Pescarmona Edoardo , Rindi Guido 
Published: June 2022

Abstract

Purpose

To correlate somatostatin receptor (SSTR) and proliferative activity profile (SSTR2, SSTR5, Ki-67) at immunohistochemistry (IHC) with SSTR-PET/CT imaging features in a retrospective series of lung neuroendocrine tumors (NET). Proliferative activity by Ki-67 and 18F-FDG-PET/CT parameters (when available) were also correlated.

Methods
Among 551 patients who underwent SSTR-PET/CT with 68Ga-DOTA-somatostatin analogs (SSA) between July 2011 and March 2020 for lung neuroendocrine neoplasms, 32 patients with a confirmed diagnosis of NET were included. For 14 of them, 18F-FDG-PET/CT was available. PET/CT images were reviewed by qualitative and semi-quantitative analyses. Immunohistochemistry for SSTR2, SSTR5, and Ki-67 was assessed. Inferential analysis was performed including kappa statistics and Spearman’s rank correlation test.

Results
Definitive diagnosis consisted of 26 typical carcinoids-G1 and six atypical carcinoids-G2. Positive SSTR2-IHC was found in 62.5% of samples while SSTR5-IHC positivity was 19.4%. A correlation between SSTR2-IHC and SSTR-PET/CT was found in 24/32 cases (75.0%, p = 0.003): 20 were concordantly positive, 4 concordantly negative. For positive IHC, 100% concordance with SSTR-PET/CT (both positive) was observed, while for negative IHC concordance (both negative) was 33.3%. In 8 cases, IHC was negative while SSTR-PET/CT was positive, even though with low-grade uptake in all but one. A significant correlation between SUVmax values at SSTR-PET/CT and the SSTR2-IHC scores was found, with low SUVmax values corresponding to negative IHC and higher SUVmax values to positive IHC (p = 0.002).

Conclusion
This retrospective study showed an overall good agreement between SSTR2-IHC and tumor uptake at SSTR-PET/CT in lung NETs. SSTR-PET/CT SUVmax values can be used as a parameter of SSTR2 density. Within the limits imposed by the relatively small cohort, our data suggest that SSTR2-IHC may surrogate SSTR-PET/CT in selected lung NET patients for clinical decision making when SSTR-PET/CT is not available.
Hamstring tendon autografts and allografts show comparable clinical outcomes and knee stability after anterior cruciate ligament reconstruction in patients over fifty years old with no signs of osteoarthritis progression
Authors: D’Ambrosi Riccardo , Giorgino Riccardo , Corona Katia , Jaykumar Tarun , Mariani Ilaria , Ursino Nicola , Mangiavini Laura , Vaishya Raju 
Published: June 2022

Abstract
Purpose
The aim of this study is to compare the functional outcomes and osteoarthritis (OA) progression after anterior cruciate ligament (ACL) reconstruction with either hamstring autografts or allografts in people over 50.

Methods
The clinical records of two consecutive cohorts of 61 cases in total over 50 years of age, undergoing ACL reconstruction, were included. The first cohort consisted of 29 allografts; the second cohort consisted of 32 autologous hamstring tendon grafts. The cases were evaluated pre- (T0) and post-operatively at six months (T1), 12 months (T2) and 24 months (T3). Clinical examination included the Lachman test, pivot shift test and objective (Objective IKDC [The International Knee Documentation Committee] score) and subjective clinical scores (Subjective IKDC score, Lysholm score and Tegner activity score). The degree of OA was evaluated using the Kellgren-Lawrence system at the time of the final follow-up, compared to the pre-operative condition.

Results
No pre-operative difference was found between the two groups (p > 0.05). No statistical difference was noted between the two groups at each follow-up (p > 0.05). At the final follow-up, both the groups significantly improved statistically in all the clinical and functional scores (p < 0.05). In both groups, one graft re-rupture was noted. No progression of OA was noted in both groups at final follow-up (p > 0.05).

Conclusion
The graft choice does not influence the outcomes two years after ACL reconstruction in people over 50; thus, both treatments help in regaining knee stability with no signs of OA progression.

Registration
Researchregistry7539–www.researchregistry.com.
Climate sensitivity of seasonal radial growth in young stands of Mexican conifers
Authors: Pompa-García Marin , Camarero J. Julio , Valeriano Cristina , Vivar-Vivar Eduardo D. 
Published: June 2022

AbstractAlteration of forest by climate change and human activities modify the growth response of trees to temperature and moisture. Growth trends of young forests with even-aged stands recruited recently when the climate became warmer and drier are not well known. We analyze the radial growth response of young conifer trees (37–63 years old) to climatic parameters and drought stress employing Pearson correlations and the Vaganov-Shashkin Lite (VS-Lite) model. This study uses tree rings of six species of conifer trees (Pinus teocote,Pinus pseudostrobus,Pinus pinceana,Pinus montezumae,Pinus ayacahuite, andTaxodium mucronatum) collected from young forests with diverse growth conditions in northern and central Mexico. Seasonal ring growth and earlywood width (EW) were modeled as a function of temperature and soil moisture using the VS-Lite model. Wet and cool conditions in the previous winter and current spring enhance ring growth and EW production, mainly in sensitive species from dry sites (P. teocote,P. pseudostrobus,P. pinceana, andP. montezumae), whereas the growth of species from mesic sites (P. ayacahuiteandT. mucronatum) shows little responsiveness to soil moisture. InP. ayacahuiteandT. mucronatum, latewood growth is enhanced by warm summer conditions. The VS-Lite model shows that low soil moisture during April and May constrains growth in the four sensitive species, particularly inP. pinceana, the species dominant in the most xeric sites. Assessing seasonal ring growth and combining its response to climate with process-based growth models could complement xylogenesis data. Such framework should be widely applied, given the predicted warming and its impact on young forests.
Business cycle characteristics of Mediterranean economies: a secular trend and cycle dynamics perspective
Authors: Solms Anna , Süssmuth Bernd 
Published: June 2022

AbstractThis study analyzes business cycle characteristics for all 20 major contemporaneous economies bordering the Mediterranean Sea based on annual real gross domestic product series for the period from 1960 to 2019. The region we investigate corresponds to the Mare Internum region of the Imperial Roman Empire during the Nerva-Antonine and early Severan dynasty, i.e., at the time of the maximum extent of the Roman Empire around 100 to 200 CE. The covered area encircles the Mediterranean, including economies now belonging to the European Union as well as acceding countries, Turkey, and the Middle East and North African economies. Using a components-deviation-cycle approach, we assess level trends and relative volatility of output. We also quantify the contribution of various factors to the business cycle variability within a region. We find cyclic commonalities and idiosyncrasies are related to ancient and colonial history and to contemporaneous trade relationships. Caliphate and Ottoman Empire membership as well as colonial rule in the twentieth century and contemporary Muslim share of population are the most promising predictors of business cycle commonalities in the region.
The X-structure/mechanism approach to beneficial nonlinear design in engineering
Authors: Jing Xingjian 
Published: June 2022

AbstractNonlinearity can take an important and critical role in engineering systems, and thus cannot be simply ignored in structural design, dynamic response analysis, and parameter selection. A key issue is how to analyze and design potential nonlinearities introduced to or inherent in a system under study. This is a must-do task in many practical applications involving vibration control, energy harvesting, sensor systems, robotic technology, etc. This paper presents an up-to-date review on a cutting-edge method for nonlinearity manipulation and employment developed in recent several years, named as the X-structure/mechanism approach. The method is inspired from animal leg/limb skeletons, and can provide passive low-cost high-efficiency adjustable and beneficial nonlinear stiffness (high static & ultra-low dynamic), nonlinear damping (dependent on resonant frequency and/or relative vibration displacement), and nonlinear inertia (low static & high dynamic) individually or simultaneously. The X-structure/mechanism is a generic and basic structure/mechanism, representing a class of structures/mechanisms which can achieve beneficial geometric nonlinearity during structural deflection or mechanism motion, can be flexibly realized through commonly-used mechanical components, and have many different forms (with a basic unit taking a shape like X/K/Z/S/V, quadrilateral, diamond, polygon, etc.). Importantly, all variant structures/mechanisms may share similar geometric nonlinearities and thus exhibit similar nonlinear stiffness/damping properties in vibration. Moreover, they are generally flexible in design and easy to implement. This paper systematically reviews the research background, motivation, essential bio-inspired ideas, advantages of this novel method, the beneficial nonlinear properties in stiffness, damping, and inertia, and the potential applications, and ends with some remarks and conclusions.
MethodViz: designing and evaluating an interactive learning tool for scientific methods – visual learning support and visualization of research process structure
Authors: Boström Lena , Sjöström Mårten 
Published: June 2022

AbstractIn this study, we focussed on designing and evaluating a learning tool for the research process in higher education. Mastering the research process seems to be a bottleneck within the academy. Therefore, there is a great need to offer students other ways to learn this skill in addition to books and lectures. The MethodViz tool supports ubiquitous aspects of the research process in their scientific works higher education students follow. Moreover, the tool facilitates and structures the process interactively. In this paper, we describe the creation process of the artefact and examine the characteristics and scope of MethodViz alongside the traits and ideas of design science research. The evaluation’s results are encouraging and show that MethodViz has the potential to improve students’ learning achievements.
Dapagliflozin Alleviates Coxsackievirus B3-induced Acute Viral Myocarditis by Regulating the Macrophage Polarization Through Stat3-related Pathways
Authors: Yan Pengcheng , Song Xiaoning , Tran Joanne , Zhou Runfa , Cao Xinran , Zhao Gang , Yuan Haitao 
Published: June 2022

Abstract—Viral myocarditis (VMC), which is most prevalently caused by Coxsackievirus B3 (CVB3) infection, is a serious clinical condition characterized by cardiac inflammation. Dapagliflozin, a kind of sodium glucose co-transporters 2(SGLT-2) inhibitor, exhibited protective effects on plenty of inflammatory diseases, while its effect on viral myocarditis has not been studied. Recently, we found the protective effect of dapagliflozin on VMC. After CVB3 infection, dapagliflozin and STATTIC (a kind of stat3 inhibitor) were given to Balb/c male mice for 8 days, and then the severity of myocarditis was assessed. Our results indicated that dapagliflozin significantly alleviated the severity of viral myocarditis, elevated the survival rate, and ameliorated cardiac function. Besides, dapagliflozin can decrease the level of pro-inflammatory cytokines including IL-1β, IL-6, and TNF-α. Furthermore, dapagliflozin can inhibit macrophages differentiate to classically activated macrophages (M1) in cardiac tissue and activate the Stat3 signal pathway which is reported to promote polarization of the alternatively activated macrophage (M2). And STATTIC can reverse these changes caused by dapagliflozin. In conclusion, we found that dapagliflozin treatment increased anti-inflammatory macrophage polarization and reduced cardiac injury following VMC via activating Stat3 signal pathway.