bluuebunny/crossref_metadata_2025_split huggingface dataset:
Into the EFThedron and UV constraints from IR consistency
Authors: Chiang Li-Yuan , Huang Yu-tin , Li Wei , Rodina Laurentiu , Weng He-Chen 
Published: March 2022

Abstract
Recently it was proposed that the theory space of effective field theories with consistent UV completions can be described as a positive geometry, termed the EFThedron. In this paper we demonstrate that at the core, the geometry is given by the convex hull of the product of two moment curves. This makes contact with the well studied bi-variate moment problem, which in various instances has known solutions, generalizing the Hankel matrices of couplings into moment matrices. We extend these solutions to hold for more general bi-variate problem, and are thus able to obtain analytic expressions for bounds, which closely match (and in some cases exactly match) numerical results from semi-definite programing methods. Furthermore, we demonstrate that crossing symmetry in the IR imposes non-trivial constraints on the UV spectrum. In particular, permutation invariance for identical scalar scattering requires that any UV completion beyond the scalar sector must contain arbitrarily high spins, including at least all even spins ℓ ≤ 28, with the ratio of spinning spectral functions bounded from above, exhibiting large spin suppression. The spinning spectrum must also include at least one state satisfying a bound $$ {m}_J^2<{M}_h^2\frac{\left({J}^2-12\right)\left({J}^4-32{J}^2+204\right)}{8\left(150-43{J}^2+2{J}^4\right)} $$

m
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h
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−
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−
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, where J2 = ℓ(ℓ+1), and Mh is the mass of the heaviest spin 2 state in the spectrum.
Synthesis of the evidence on the impact of pre-operative direct oral anticoagulants on patient health outcomes after hip fracture surgery: rapid systematic review
Authors: Mitchell Rebecca J. , Jakobs Sophie , Halim Nicole , Seymour Hannah , Tarrant Seth 
Published: March 2022

Abstract
Purpose
To synthesise the evidence on the impact of pre-operative direct oral anticoagulants (DOACs) on health outcomes for patients who sustain a hip fracture.

Method
A rapid systematic review of three databases (MEDLINE, Embase and Scopus) for English-language articles from January 2000 to August 2021 was conducted. Abstracts and full text were screened by two reviewers and articles were critically appraised. Data synthesis was undertaken to summarise health outcomes examined for DOAC users versus a no anticoagulant group. Key information was extracted for study type, country and time frame, population and sample size, type of DOACs, comparator population(s), key definitions, health outcome(s), and summary study findings.

Results
There were 21 articles identified. Of the 18 studies that examined time to surgery, 12 (57.1%) found DOAC users had a longer time to surgery than individuals not using anticoagulants. Five (83.3%) of six studies identified that DOAC users had a lower proportion of surgery conducted within 48 h Four (40.0%) of ten studies reporting hospital length of stay (LOS) identified a higher LOS for DOAC users. Where reported, DOAC users did not have increased mortality, blood loss, transfusion rates, complication rates of stroke, re-operation or readmissions compared to individuals not using anticoagulants.

Conclusions
The effect of DOAC use on hip fracture patient health was mixed, although patients on DOACs had a longer time to surgery. The review highlights the need for consistent measurement of health outcomes in patients with a hip fracture to determine the most appropriate management of patients with a hip fracture taking DOACs.
Survivorship-Care-Programme für Krebspatienten: die Bedeutung von Risikostratifizierung, Selbstmanagement- und Gesundheitskompetenzen im Zeitalter digitaler Versorgung
Authors: Mehnert-Theuerkauf Anja , Esser Peter 
Published: March 2022

ZusammenfassungIn Deutschland wie allen anderen Industrieländern weltweit nimmt mit einer älter werdenden Bevölkerung und einer verbesserten Krebsfrüherkennung, Diagnostik und onkologischen Behandlung die Zahl der Patienten, die geheilt werden oder lange Zeit mit der Erkrankung leben, deutlich zu (Cancer Survivors). Ein Leben mit und nach einer Krebserkrankung bedeutet für viele Patienten ein Leben mit körperlichen und psychosozialen krankheits- und behandlungsbedingten Langzeit- und Spätfolgen. Angesichts des demografischen Wandels, der steigenden Krebsprävalenz sowie des medizinischen Fortschritts ist eine der dringenden Fragen, wie eine qualitativ hochwertige individualisierte und gleichzeitig finanzierbare Krebsversorgung für älter werdende, häufig multimorbide Patienten sichergestellt werden kann.Diese Entwicklungen erfordern neben einer Stärkung der Krebsprävention die Erforschung und Umsetzung einer individualisierten Nachsorge im Rahmen von Survivorship-Care-Programmen (SCP). Übergreifende Zielsetzung von SCP ist es, den körperlichen wie psychosozialen Langzeit- und Spätfolgen vorzubeugen bzw. diese zu minimieren, die Mortalität zu senken sowie die Lebensqualität von Patienten zu verbessern. Die Evidenz zur Wirksamkeit von SCP hinsichtlich der Verbesserung patientenberichteter Endpunkte ist bislang nicht eindeutig. Die Bereitstellung von maßgeschneiderten Informationen sowie von risikomodifizierenden und bedarfsorientierten Angeboten auf der Basis einer Risikostratifizierung wird als zentraler Bestandteil bei der Implementierung von SCP angesehen. Dabei nimmt die Förderung von Selbstmanagement- und Gesundheitskompetenzen der Patienten, insbesondere vor dem Hintergrund der Zunahme von digitalen Gesundheitsanwendungen, einen hohen Stellenwert ein.
Branch-duct intraductal papillary mucinous neoplasm (IPMN): Are cyst volumetry and other novel imaging features able to improve malignancy prediction compared to well-established resection criteria?
Authors: Pozzi Mucelli Raffaella M. , Moro Carlos Fernández , Del Chiaro Marco , Valente Roberto , Blomqvist Lennart , Papanikolaou Nikolaos , Löhr Johannes-Matthias , Kartalis Nikolaos 
Published: March 2022

Abstract
Objectives
Current guidelines base the management of intraductal papillary mucinous neoplasms (IPMN) on several well-established resection criteria (RC), including cyst size. However, malignancy may occur in small cysts. Since branch-duct (BD) IPMN are not perfect spheres, volumetric and morphologic analysis might better correlate with mucin production and grade of dysplasia. Nonetheless, their role in malignancy (high-grade dysplasia/invasive cancer) prediction has been poorly investigated. Previous studies evaluating RC also included patients with solid-mass-forming pancreatic cancer (PC), which may affect the RC yield. This study aimed to assess the role of volume, morphology, and other well-established RC in malignancy prediction in patients with BD- and mixed-type IPMN after excluding solid masses.

Methods
Retrospective ethical review-board-approved study of 106 patients (2008–2019) with histopathological diagnosis of BD- and mixed-type IPMN (without solid masses) and preoperative MRI available. Standard imaging and clinical features were collected, and the novel imaging features cyst-volume and elongation value [EV = 1 − (width/length)] calculated on T2-weighted images. Logistic regression analysis was performed. Statistical significance set at two-tails, p < 0.05.

Results
Neither volume (odds ratio (OR) = 1.01, 95% CI: 0.99–1.02, p = 0.12) nor EV (OR = 0.38, 95% CI: 0.02–5.93, p = 0.49) was associated with malignancy. Contrast-enhancing mural nodules (MN), main pancreatic duct (MPD) ≥ 5 mm, and elevated carbohydrate antigen (CA) 19-9 serum levels (> 37 μmol/L) were associated with malignancy (MN OR: 4.32, 95% CI: 1.18–15.76, p = 0.02; MPD ≥ 5 mm OR: 4.2, 95% CI: 1.34–13.1, p = 0.01; CA19-9 OR: 6.72; 95% CI: 1.89 – 23.89, p = 0.003).

Conclusions
Volume and elongation value cannot predict malignancy in BD- and/or mixed-type IPMN. Mural nodules, MPD ≥ 5 mm and elevated CA19-9 serum levels are associated with higher malignancy risk even after the exclusion of solid masses.

Key Points
• Novel and well-established resection criteria for IPMN have been evaluated after excluding solid masses.
• BD-IPMN volume and elongation value cannot predict malignancy.
• Main pancreatic duct ≥ 5 mm, mural nodules, and elevated carbohydrate antigen 19-9 levels are associated with malignancy.
Novel first and second order numerical differentiation techniques and their application to nonlinear analysis of Kirchhoff–Love shells
Authors: Leonetti Leonardo , Mukhametzhanov Marat S. 
Published: March 2022

AbstractNumerical simulation based on FEM/IGA methods is the standard approach for the approximated solution of applied physical problems. In this context, the differentiation of the numerical counterpart of mechanical fields is required. Moreover, the differentiated function can have a complicated shape, depend on many variables and change within the process. Many state-of-the-art numerical differentiation methods are not suitable for this kind of applications and the common way is to exploit analytical differentiation. Thus, an on-the-fly differentiation method is desirable particularly when the process is complicated and when new mechanical models are under development. In this paper, a new method is proposed for a precise computation of the gradient and Hessian. This method has been applied to nonlinear analysis of Kirchhoff–Love shells, which can be considered as an appropriate test bench to prove the reliability in relevant physical context. Numerical experiments show the advantages of the proposed techniques with respect to standard approaches.
Influence of weather conditions and projected climate change scenarios on the suitability of Vitis vinifera cv. Carignan in Rioja DOCa, Spain
Authors: Ramos M.C. , Martínez de Toda F. 
Published: March 2022

AbstractGrape development and its quality are highly dependent on soil and weather conditions. Under the progressive warming, which can affect the suitability of typical varieties grown in a given area, the knowledge of the vine response to changes in climate is essential to stablish strategies to maintain the viticulture sector. This research presents an analysis of phenology and grape composition of the Carignan cultivar, during a 13-year period, at two locations in Rioja DOCa. Based on the results obtained and the projected changes in climate under climate change scenarios (RC4.5 and RCP8.5), the response of this cultivar was evaluated. Differences in the phenological dates of up to 18, 29 and 40 days, for flowering, veraison and harvest, respectively, were observed between the warmest and the coolest years. An advance of up to 5, 8 and 11 days, respectively, for the mentioned stages, is projected under the RCP4.5 scenario by 2050, which could be near 1.5*times higher under the RCP8.5 scenario. These advances will be mainly driven by the temperatures recorded in the previous period. Grape acidity was mainly driven by water availability, in particular during ripening, which imply a slight projected reduction due to precipitation changes but not significant effect due to increasing temperatures. The phenolic composition could be positively affected by increasing temperatures and increasing water deficits, since this variety does not always reach a complete maturity at present. Thus, under the projected warming scenarios, the suitability of Carignan in Rioja DOCa was confirmed.
Domain object hierarchies inducing multi-level models
Authors: Neumayr Bernd , Schrefl Michael 
Published: March 2022

AbstractConceptual modeling of domain object hierarchies, such as product hierarchies or organization hierarchies, is difficult due to the intricate nature of nonphysical domain objects organized in such hierarchies. Modeling domain object hierarchies as part-whole hierarchies covers their hierarchical structure, yet to capture their meaning, part-whole hierarchies have to be combined with specialization and multi-level instantiation. To this end we introduce the deep domain object (DDO) multi-level modeling pattern and approach. With the DDO approach, subclasses and metaclasses are induced by and integrated with the part-whole hierarchy. The approach is aligned with the multi-level theory (MLT) and formalized by a metamodel and a set of deductive rules implemented in F-Logic. The proof-of-concept prototype is used for automated application of the pattern and for querying induced multi-level models.
What is new in microcirculation and tissue oxygenation monitoring?
Authors: de Keijzer Ilonka N. , Massari Dario , Sahinovic Marko , Flick Moritz , Vos Jaap Jan , Scheeren Thomas W. L. 
Published: March 2022

AbstractEnsuring and maintaining adequate tissue oxygenation at the microcirculatory level might be considered the holy grail of optimal hemodynamic patient management. However, in clinical practice we usually focus on macro-hemodynamic variables such as blood pressure, heart rate, and sometimes cardiac output. Other macro-hemodynamic variables like pulse pressure or stroke volume variation are additionally used as markers of fluid responsiveness. In recent years, an increasing number of technological devices assessing tissue oxygenation or microcirculatory blood flow have been developed and validated, and some of them have already been incorporated into clinical practice. In this review, we will summarize recent research findings on this topic as published in the last 2 years in the Journal of Clinical Monitoring and Computing (JCMC). While some techniques are already currently used as routine monitoring (e.g. cerebral oxygenation using near-infrared spectroscopy (NIRS)), others still have to find their way into clinical practice. Therefore, further research is needed, particularly regarding outcome measures and cost-effectiveness, since introducing new technology is always expensive and should be balanced by downstream savings. The JCMC is glad to provide a platform for such research.
Peer Microaggressions and Social Skills among School-Age Children of Sexual Minority Parents through Assisted Reproduction: Moderation via the Child–Teacher Relationship
Authors: Carone Nicola , Innocenzi Eleonora , Lingiardi Vittorio 
Published: March 2022

AbstractThe impact of peer microaggressions and the child–teacher relationship on the social skills of children with sexual minority parents has received little attention. The current study used a mixed-method, multi-informant, two-wave longitudinal design to address this research gap. Thirty-seven children of lesbian mothers through donor insemination and 33 children of gay fathers though surrogacy (wave 1: Mage = 8.3 years, SD = 1.6; 51.4% female; wave 2: Mage = 9.9 years, SD = 1.7), all school-aged and residing in Italy, participated together with their 140 parents and 55 teachers. Approximately two-thirds of the children reported at least one peer microaggression and, on average, microaggressions were of a low intensity. Child–teacher relationships were of high quality (i.e., characterized by high safe haven–seeking and secure base use, and low conflict). Both parents and teachers reported high levels of child social skills. However, more intense W1 microaggressions predicted lower W2 social skills among children reporting a lower W1 child–teacher relationship quality, and greater W2 social skills among those reporting a higher W1 child–teacher relationship quality. These results support the child–teacher relationship as a potentially secure context in which children can “mentalize” negative experiences such as microaggressions and improve their social skills. In this vein, considering microaggression, attachment, and developmental intergroup theories, teachers must attune to the school experiences of children with sexual minority parents and cultivate caring classroom environments that are sensitive to family diversity.
Electron beam irradiation treatment of textiles materials: a review
Authors: Abou Elmaaty Tarek , Okubayashi Satoko , Elsisi Hanan , Abouelenin Shahinaz 
Published: March 2022

AbstractElectron beam irradiation technology has gained more attention as it appears to be a promising economically and environmentally sustainable alternative to traditional wet-chemical processing. It is an advanced approach that is clean, solvent-free, time-saving, and ecologically benign with acceptable handling and operation properties. This review provides a study of the latest literature on the technology of electron beam irradiation surface modification of textile. Considerable emphasis is also placed on the most novel applications of electron beam irradiation such as the functionalization of textile materials, which leads to the development of alternative sustainable techniques or revolutionary advanced materials soon.
Graphical abstract
Benefits of silicon-enhanced root nodulation in a model legume are contingent upon rhizobial efficacy
Authors: Putra Rocky , Waterman Jamie M. , Mathesius Ulrike , Wojtalewicz Dominika , Powell Jeff R. , Hartley Susan E. , Johnson Scott N. 
Published: March 2022

Abstract
Aims
Silicon (Si) uptake and accumulation improves plant resilience to environmental stresses, but most studies examining this functional role of Si have focussed on grasses (Poaceae) and neglected other important plant groups, such as legumes (Fabaceae). Legumes have evolved a symbiotic relationship with nitrogen-fixing bacteria (rhizobia) housed in root nodules. Our study determined the impacts of silicon (Si) supplementation on Medicago truncatula inoculated with Ensifer meliloti rhizobial strains that differed in their capacity for nitrogen fixation: Sm1021 (‘low-efficiency’) or Sm1022 (‘high-efficiency’).

Methods
We examined how Si and rhizobial efficacy influence nodule and plant functional traits, including their chemical aspects. These combinations were supplied with or without Si in a glasshouse experiment, where we quantified nodule flavonoids and foliar chemistry (free amino acids, soluble protein, elemental C, N and Si).

Results
Si supply increased nodule number per plant, specific nodule flavonoid concentrations, contents of foliar nitrogenous compounds and foliar C, but not foliar Si. We also demonstrated that rhizobial efficacy altered the magnitude of Si effects on certain traits. For example, Si significantly promoted concentrations of foliar N and soluble protein in the plants associated with the ‘low-efficiency’ strain only, and this was not the case with the ‘high-efficiency’ one.

Conclusions
Collectively, our study indicates that Si generates positive effects on M. truncatula, particularly when the association with rhizobia is relatively inefficient, and may play a more prominent role in rhizobial functionality than previously thought.
Severe and Fatal Cycling Crash Injury in Britain: Time to Make Urban Cycling Safer
Authors: Mason-Jones Amanda J. , Turrell Stephen , Gomez Gerardo Zavala , Tait Caroline , Lovelace Robin 
Published: March 2022

AbstractPedal cycling is advocated for increasing physical activity and promoting health and wellbeing. However, whilst some countries have achieved zero cyclist deaths on their roads, this is not the case for Great Britain (GB). A retrospective cross-sectional analysis was conducted of STATS19 cyclist crash data, a dataset of all police-reported traffic crashes in GB. Information about crash location, casualty, driver and vehicles involved were included as predictors of casualty severity (fatal or severe vs. slight). Sixteen thousand one hundred seventy pedal cycle crashes were reported during 2018. Severe or fatal cyclist crash injury was associated with increasing age of the cyclist (35–39 years, OR 1.38, 95% CI 1.11 to 1.73; 55–59 years, OR 1.73, 95% CI 1.35 to 2.2; 70 years and over, OR 2.87, 95% CI 2.12 to 3.87), higher road speed limits (50 MPH OR 2.10, 95% CI 1.43 to 3.07; 70 MPH OR 4.12, 95% CI 2.12 to 8.03), the involvement of goods vehicles (OR 2.08, 95% CI 1.30 to 3.33) and the months of May and June (OR 1.34 to 1.36, 95% CI 1.06 to 1.73). Urban planning that includes physical separation of pedal cyclists from other road users, raising awareness around the risks from goods vehicles and reducing road speed should be the urgent focus of interventions to increase the benefits and safety of cycling.
Tailoring work participation support for cancer survivors using the stages of change: perspectives of (health care) professionals and survivors
Authors: Zegers Amber D. , Coenen Pieter , Bültmann Ute , van Hummel Ragna , van der Beek Allard J. , Duijts Saskia F. A. 
Published: March 2022

Abstract
Purpose
Interventions to support work participation in cancer survivors (CSs) have shown limited effectiveness. Applying a behavioral change framework (e.g., stages of change) could make work participation interventions for CSs more timely and tailored. We aimed to explore the application of the stages of change framework to work participation support for CSs and to generate stage-specific intervention content.

Methods
Eighteen experts (e.g., occupational physicians, reintegration consultants) were individually interviewed, and three focus groups with CSs (n = 6, n = 5, n = 4) were conducted. Data were analyzed along the six work-related behavioral change stages purported by the readiness for return to work framework, which is based on the stages of change.

Results
The following themes were identified: (1) pre-contemplation: emotional support and staying connected—encourage contact with the employer/colleagues; (2) contemplation: considering return to work is stressful—facilitate the deliberation process; (3) preparation self-evaluative: assess current capabilities—seek guidance from, e.g., occupational physicians; (4) preparation behavioral: planning return to work—allow for personalized solutions and encourage supervised return to work; (5) uncertain maintenance: guard against overload—train self-efficacy strategies and communication tactics; and (6) proactive maintenance: accept and prepare for the long term.

Conclusions
Our results support the potential utility of tailoring CSs’ work participation support along the stages of change.

Implications for Cancer Survivors
We provided recommendations for intervention content and developed a stage-specific work participation intervention for CSs, the effectiveness of which will be evaluated in an upcoming randomized controlled trial.
The Role of High-Density Lipoprotein Cholesterol in 2022
Authors: Sirtori Cesare R. , Corsini Alberto , Ruscica Massimiliano 
Published: March 2022

Abstract
Purpose of the Review
High-density lipoproteins (HDL) are responsible for the transport in plasma of a large fraction of circulating lipids, in part from tissue mobilization. The evaluation of HDL-associated cholesterol (HDL-C) has provided a standard method for assessing cardiovascular (CV) risk, as supported by many contributions on the mechanism of this arterial benefit. The present review article will attempt to investigate novel findings on the role and mechanism of HDL in CV risk determination.

Recent Findings
The most recent research has been aimed to the understanding of how a raised functional capacity of HDL, rather than elevated levels per se, may be responsible for the postulated CV protection. Markedly elevated HDL-C levels appear instead to be associated to a raised coronary risk, indicative of a U-shaped relationship.

Summary
While HDL-C reduction is definitely related to a raised CV risk, HDL-C elevations may be linked to non-vascular diseases, such as age-related macular disease. The description of anti-inflammatory, anti-oxidative and anti-infectious properties has indicated potential newer areas for diagnostic and therapeutic approaches. In the last two decades inconclusive data have arisen from clinical trials attempting to increase HDL-C pharmacologically or by way of recombinant protein infusions (most frequently with the mutant A-I Milano); prevention of stent occlusion or heart failure treatment have shown instead significant promise. Targeted clinical studies are still ongoing.