bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mergers, Acquisitions and Merger Control in an Algorithmic Pricing World
Authors: Coutts Michael David 
Published: June 2022

AbstractThis paper considers whether pricing algorithms present novel issues that existing merger control frameworks and practices are inadequate to address, particularly in relation to pre-merger disclosure of pricing algorithms and the suitability of current tests and remedies for addressing coordinated effects. Through a comparative and critical analysis of the merger control regimes and practices of the European Union, United Kingdom, and Australia, this paper finds that whilst such regimes and practices are broadly adequate for dealing with algorithmic transactions, there are nonetheless potential areas for improvement. Disclosure of a pricing algorithm may contravene prohibitions on the sharing of competitively sensitive information. As such, merger parties may need to rethink aspects of their usual due diligence procedures. Pricing algorithms may also increase the potential for coordinated effects to arise in some markets that would ordinarily have been considered too complex, asymmetric, opaque, or insufficiently concentrated for tacit coordination to occur, or be used to retaliate more effectively against deviations from a coordinated equilibrium, or to raise the height of barriers to entry. Competition authorities may therefore need to amend their standard approach to investigating and assessing coordinated effects, as well as their traditional approach to remedies.
Survival outcome of cervical cancer patients treated by image-guided brachytherapy: a ‘real world’ single center experience in Thailand from 2008 to 2018
Authors: Tharavichitkul Ekkasit , Jia-Mahasap Bongkot , Muangwong Pooriwat , Chakrabandhu Somvilai , Klunklin Pitchayaponne , Onchan Wimrak , Tippanya Damrongsak , Nobnop Wannapa , Watcharawipha Anirut , Kittidachanan Kittikun , Galalae Ravan M , Chitapanarux Imjai 
Published: June 2022

Abstract
The objective of our study was to evaluate the survival outcome of cervical cancer patients treated using image-guided brachytherapy (IGBT). From 2008 to 2018, 341 patients with cervical cancer were treated by radical radiotherapy. IGBT (by computed tomography [CT] or transabdominal ultrasound [TAUS]) was used to treat all of these patients. The characteristic data and patient status after treatment were recorded. All data were evaluated for survival outcome analysis. From a total of 341 patients, 295 patients were analyzed and 46 patients were excluded due to data missing in the survival outcomes. At the median follow-up time of 48 months (IQR 30–80 months), The 4-year local control, progression-free survival and overall survival rates were 89.5%, 74.9% and 69.1%, respectively. For overall survival, the size (&gt; 5 cm), pathology (non-SCCA), stage (stage III–IV by FIGO 2009), lymph node (LN) (presented) and overall treatment time (OTT) (&gt; 56 days) showed statistical significance in univariate analysis while non-SCCA pathology, advanced stage, presented LN and longer OTT showed statistical significance in multivariate analysis. In conclusion, our analysis reports a 4-year overall survival rate of 69.1%. Non-SCCA pathology, advanced stage disease, LN presence and longer OTT showed worse prognostic factors in multivariate analysis.
Sir Daniel Fleming, 1633–1701: Magistrate, Antiquary and Book-Collector
Authors: Barker Nicolas 
Published: June 2022

Abstract
Sir Daniel Fleming, 1633–1701, came of a family long established in Westmorland, where he served as a magistrate, and recorder of public events. He accumulated a considerable library of mainly English books, which he marked in a distinctive manner. This collection passed through the hands of his descendants over three hundred years, including his son Sir George Fleming, bishop of Carlisle 1735–47), and ending with the neighbouring Senhouse family. The nature and form of the books thus accumulated are discussed, together with the life and times of the last member of the family, Roger Senhouse (1899–1970).
Eclipse timing variations in post-common envelope binaries: Are they a reliable indicator of circumbinary companions?
Authors: Pulley D , Sharp I D , Mallett J , von Harrach S 
Published: June 2022

ABSTRACT
Post-common envelope binary systems evolve when matter is transferred from the primary star at a rate that cannot be accommodated by its secondary companion. A common envelope forms, which is subsequently ejected resulting in a system with a binary period frequently between 2 and 3 h. Where circumbinary companions are predicted, it remains unclear whether they form before or after the common envelope ejection. From observations of eclipse timing variations (ETVs), exoplanet data bases e.g. NASA Exoplanet Archive, list typically a dozen systems with confirmed circumbinary planets. Here, we examine seven of these systems, discuss other possible causes, and consider whether, for these dynamic systems, the ETV methodology is a reliable indicator of planetary companions. The systems selected were those where we could determine precise eclipse timings, free from significant extraneous effects such as pulsations, and present 163 new times of minima permitting us to test existing models. Over 30 circumbinary models have been proposed for these seven systems and note that all, other than the latest model for NY Vir, which remains to be fully tested, fail within a year to accurately predict eclipse times. In examining alternative mechanisms, we find that magnetic effects could contribute significantly in two of the seven systems studied. We conclude that the structure of these dynamic systems, with the extreme temperature differences and small binary separations, is not fully understood and that many factors may contribute to the observed ETVs.
On the relationship between the duration and energy of non-repeating fast radio bursts: census with the CHIME data
Authors: Kim Seong Jin , Hashimoto Tetsuya , Chen Bo Han , Goto Tomotsugu , Ho Simon C-C , Hsiao Tiger Yu-Yang , Wong Yi Hang Valerie , Yamasaki Shotaro 
Published: June 2022

ABSTRACT
A correlation between the intrinsic energy and the burst duration of non-repeating fast radio bursts (FRBs) has been reported. If it exists, the correlation could be used to estimate the intrinsic energy from the duration, and thus could provide a new distance measure for cosmology. However, the correlation arose from small-number statistics (68 FRBs) and was not free from contamination by latent repeating populations, which might not have such a correlation. Finding a way to separate/exclude the repeating bursts from the mixture of all different types of FRBs is essential for investigating this property. Using a much larger sample from the new FRB catalogue (containing 536 FRBs) recently released by the CHIME (Canadian Hydrogen Intensity Mapping Experiment)/FRB Project, combined with a new classification method developed based on unsupervised machine learning, we carried out further scrutiny of the relationship. We found that there is a weak correlation between the intrinsic energy and duration for non-repeating FRBs at z &lt; 0.3, with a Kendall τ correlation coefficient of 0.239 and a significance of 0.001 (statistically significant), whose slope looks similar to that of gamma-ray bursts. This correlation becomes weaker and insignificant at higher redshifts (z &gt; 0.3), possibly owing to the lack of faint FRBs at high z and/or the redshift evolution of the correlation. The ‘scattering time’ in the CHIME/FRB catalogue shows an intriguing trend: it varies along the line obtained from a linear fit on the energy versus duration plane between these two parameters. A possible cosmological application of the relationship must wait for more observations of faint FRBs at high z.
Magnetic confinement of dense plasma inside (and outside) stellar coronae
Authors: Waugh Rose F P , Jardine Moira M 
Published: June 2022

ABSTRACT
Magnetic confinement of dense plasma is found in the magnetospheres of both high- and low-mass stars. Trapped material traces the magnetic field structure, often at large distances from the star where the magnetic structure is otherwise difficult to observe. This work looks specifically at rapidly rotating, solar-like stars where this behaviour is well observed in the form of ‘slingshot’ prominences. We have produced a model for generating cooled magnetic loops in equilibrium with a range of coronal magnetic fields. These loops can be used to populate model coronae and confine material at a wide range of heights above the stellar surface. We calculate masses for slingshot prominences for the star AB Doradus that are consistent with observational values. The model produces two types of solution: loops with summits at low heights and tall solutions beyond the co-rotation radius. We show that the low-lying solutions are footpoint heavy and generally follow the shape of the background field. We refer to these as solar-like prominences. The tall solutions are summit heavy and are centrifugally supported. These are are the slingshot prominences. These tall solutions can be found within the stellar wind, beyond the closed corona. H α trails are generated for various coronal field structures with a range of field geometries and coronal extents. Similar H α trails are produced by a range of global field structures, which implies that magnetic confinement of material should be common in rapidly rotating stars.
FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1
Authors: Wang Yan , Wang Kai , Fu Jiale , Zhang Yu , Mao Yufei , Wang Xu , Wang Xiang , Yu Rutong , Zhou Xiuping 
Published: June 2022

Abstract

Background
We previously report that yes-associated protein (YAP), the core downstream effector of Hippo pathway, promotes the malignant progression of glioblastoma (GBM). However, although classical regulatory mechanisms of YAP are well explored, how YAP is modulated by the Hippo-independent manner remains poorly understood. Meanwhile, the nonreceptor tyrosine kinase Fyn-related kinase (FRK), which exhibits low expression and possesses tumor suppressor effects in GBM, is reported to be involved in regulation of protein phosphorylation. Here, we examined whether FRK could impede tumor progression by modulating YAP activities.

Methods
Human GBM cells and intracranial GBM model were used to assess the effects of FRK and YAP on the malignant biological behaviors of GBM. Immunoblotting and immunohistochemistry were used to detect the expression of core proteins in GBM tissues. Co-immunoprecipitation, proximity ligation assay, luciferase assay and ubiquitination assay were utilized to determine the protein–protein interactions and related molecular mechanisms.

Results
The expression levels of FRK and YAP were inversely correlated with each other in glioma tissues. In addition, FRK promoted the ubiquitination and degradation of YAP, leading to tumor suppression in vitro and in vivo. Mechanistically, FRK interacted with and phosphorylated YAP on Tyr391/407/444, which recruited the classical E3 ubiquitin ligase Siah1 to catalyze ubiquitination and eventually degradation of YAP. Siah1 is required for YAP destabilization initiated by FRK.

Conclusions
We identify a novel mechanism by which FRK orchestrates tumor-suppression effect through phosphorylating YAP and inducing its ubiquitination by Siah1. FRK-Siah1-YAP signaling axis may serve as a potential therapeutic target for GBM treatment.
Targeting protein arginine methyltransferase 5 sensitizes glioblastoma to trametinib
Authors: Banasavadi-Siddegowda Yeshavanth Kumar , Namagiri Sriya , Otani Yoshihiro , Sur Hannah , Rivas Sarah , Bryant Jean-Paul , Shellbourn Allison , Rock Mitchell , Chowdhury Ashis , Lewis Cole T , Shimizu Toshihiko , Walbridge Stuart , Kumarasamy Sivarajan , Shah Ashish H , Lee Tae Jin , Maric Dragan , Yan Yuanqing , Yoo Ji Young , Kumbar Sangamesh G , Heiss John D , Kaur Balveen 
Published: June 2022

Abstract

Background
The prognosis of glioblastoma (GBM) remains dismal because therapeutic approaches have limited effectiveness. A new targeted treatment using MEK inhibitors, including trametinib, has been proposed to improve GBM therapy. Trametinib had a promising preclinical effect against several cancers, but its adaptive treatment resistance precluded its clinical translation in GBM. Previously, we have demonstrated that protein arginine methyltransferase 5 (PRMT5) is upregulated in GBM and its inhibition promotes apoptosis and senescence in differentiated and stem-like tumor cells, respectively. We tested whether inhibition of PRMT5 can enhance the efficacy of trametinib against GBM.

Methods
Patient-derived primary GBM neurospheres (GBMNS) with transient PRMT5 knockdown were treated with trametinib and cell viability, proliferation, cell cycle progression, ELISA, and western blot were analyzed. In vivo, NSG mice were intracranially implanted with PRMT5-intact and -depleted GBMNS, treated with trametinib by daily oral gavage, and observed for tumor progression and mice survival rate.

Results
PRMT5 depletion enhanced trametinib-induced cytotoxicity in GBMNS. PRMT5 knockdown significantly decreased trametinib-induced AKT and ERBB3 escape pathways. However, ERBB3 inhibition alone failed to block trametinib-induced AKT activity suggesting that the enhanced antitumor effect imparted by PRMT5 knockdown in trametinib-treated GBMNS resulted from AKT inhibition and not ERBB3 inhibition. In orthotopic murine xenograft models, PRMT5-depletion extended the survival of tumor-bearing mice, and combination with trametinib further increased survival.

Conclusion
Combined PRMT5/MEK inhibition synergistically inhibited GBM in animal models and is a promising strategy for GBM therapy.
Working with curiosity: Knowledge transfer practitioners’ ambivalence at CERN
Authors: Yeh Chih-wei 
Published: June 2022

AbstractCurrent science-policy trends emphasise efficiency, application orientation, and accountability. This article is inspired by the discovery of the Higgs boson in 2012; the author studies how the knowledge transfer practitioners at the European Organization for Nuclear Research (CERN), the birthplace of the Higgs boson, account for their experiences at CERN. In the body of the Science Policy Studies literature, the knowledge transfer practitioners’ perspective on the wider impacts of particle and high-energy physics research is relatively understudied. The data are generated from qualitative interviews. Constructivist discourse analysis, which is introduced from Science and Technology Studies, is applied to the data; namely, this research focuses on the practitioners’ worldview and their perceived situation at CERN. As a result, there is a repetitive sense of ambivalence towards knowledge transfer in the discourse. Practical suggestions are provided in response to this ambivalence.
Effects of a multi-strain Bacillus subtilis-based direct-fed microbial on immunity markers and intestinal morphology in diets fed to weanling pigs
Authors: Lewton Jaron R , Woodward Adrienne D , Moser Ronny L , Thelen Kyan M , Moeser Adam J , Trottier Nathalie L , Tempelman Robert J , Rozeboom Dale W 
Published: June 2022

Abstract
The objective of this experiment was to evaluate the effects of a multi-strain Bacillus subtilis-based direct-fed microbial (DFM) on nursery pig health as indicated by intestinal mucosal and blood plasma immunological markers and intestinal morphology. Eighty pigs, of equal number of barrows and gilts (initial BW: 7.0 ± 0.60 kg), weaned at 21 ± 1 d of age were randomly allotted to sixteen pens, with five pigs per pen. Two dietary treatments were implemented, a basal control (CON) and a basal control plus DFM (CDFM). Both diets were corn, soybean meal, and distillers dried grains based and were formulated to meet or exceed all nutritional requirements (NRC, 2012) and manufactured on site. Diets were fed for 42 d. On d 21 and 42 of the experiment, one pig per pen was randomly selected and euthanized, with equal number of males and females represented. Blood samples were collected prior to euthanasia for assessment of plasma concentrations of immunoglobulin A (IgA) and intestinal fatty acid binding protein. Segments of the gastrointestinal tract including duodenum, jejunum, ileum, ascending and distal colon were removed for analysis of intestinal morphology, and levels of interleukin 6, interleukin 10 (IL-10), and tumor necrosis factor alpha. Jejunal villus height was greater in the CDFM pigs as compared with CON pigs (P = 0.02) and ascending colon crypt depth tended to be greater on d 21 (P = 0.10). Compared to CON, CDFM significantly increased overall plasma IgA (P = 0.03) (0.58 vs. 0.73 0.05 mg/mL, respectively), while it tended to increase plasma IgA (P = 0.06) on d 21 (0.34 vs. 0.54 ± 0.07 mg/mL, respectively) and tended to increase overall IL-10 (P = 0.10) in the jejunum (113 vs. 195 ± 35 pg/mL, respectively). Addition of a multi-strain Bacillus subtilis-based DFM may have an early benefit to nursery pig health status, observed through specific changes in morphology and both systemic and localized immunological markers.
Neural basis for anxiety and anxiety-related physiological responses during a driving situation: an fMRI study
Authors: Sasaoka Takafumi , Harada Tokiko , Sato Daichi , Michida Nanae , Yonezawa Hironobu , Takayama Masatoshi , Nouzawa Takahide , Yamawaki Shigeto 
Published: June 2022

Abstract
Although the exteroceptive and interoceptive prediction of a negative event increases a person’s anxiety in daily life situations, the relationship between the brain mechanism of anxiety and the anxiety-related autonomic response has not been fully understood. In this functional magnetic resonance imaging (fMRI) study, we examined the neural basis of anxiety and anxiety-related autonomic responses in a daily driving situation. Participants viewed a driving video clip in the first-person perspective. During the video clip, participants were presented with a cue to indicate whether a subsequent crash could occur (attention condition) or not (safe condition). Enhanced activities in the anterior insula, bed nucleus of the stria terminalis, thalamus, and periaqueductal gray, and higher sympathetic nerve responses (pupil dilation and peripheral arterial stiffness) were triggered by the attention condition but not with the safe condition. Autonomic response-related functional connectivity was detected in the visual cortex, cerebellum, brainstem, and MCC/PCC with the right anterior insula and its adjacent regions as seed regions. Thus, the right anterior insula and adjacent regions, in collaboration with other regions play a role in eliciting anxiety based on the prediction of negative events, by mediating anxiety-related autonomic responses according to interoceptive information.
Community-Based Participatory Research and Human-Centered Design Principles to Advance Hearing Health Equity
Authors: Marrone Nicole L. , Nieman Carrie L. , Coco Laura 
Published: June 2022

Objectives:
Inclusive and equitable research is an ethical imperative. Community-based participatory research (CBPR) as well as human-centered design are approaches that center partnership between community members and academic researchers. Together, academic-community research teams iteratively study community priorities, collaboratively develop ethical study designs, and co-create innovations that are accessible and meaningful to the community partners while advancing science. The foundation of the CBPR approach is reliant on its core principles of equity, colearning, shared power in decision-making, reciprocity, and mutual benefit. While the CBPR approach has been used extensively in public health and other areas of healthcare research, the approach is relatively new to audiology, otolaryngology, and hearing health research. The purpose of the present article is to advance an understanding of the CBPR approach, along with principles from human-centered design, in the context of research aimed to advance equity and access in hearing healthcare.

Design:
The literature is reviewed to provide an introduction for auditory scientists to the CBPR approach and human-centered design, including discussion of the underlying principles of CBPR and where it fits along a community-engaged continuum, theoretical and evaluation frameworks, as well as applications within auditory research.

Results:
Recent applications of CBPR have been framed broadly within the theoretical positions of the socioecological model for a systems-level approach to community-engaged research and the Health Services Utilization model within health services and disparities research using CBPR. Utilizing human-centered design strategies can work in tandem with a CBPR approach to engage a wide range of people in the research process and move toward the development of innovative yet feasible solutions.

Conclusions:
Leveraging the principles of CBPR is an intricate and dynamic process, may not be a fit for some topics, some researchers’ skillsets, and may be beyond some projects’ resources. When implemented skillfully and authentically, CBPR can be of benefit by elevating and empowering community voices and cultural perspectives historically marginalized in society and underrepresented within research. With a focus on health equity, this review of CBPR in the study of hearing healthcare emphasizes how this approach to research can help to advance inclusion, diversity, and access to innovation.
DermACELL Acellular Dermal Matrix in Oncologic Breast Reconstruction: A Cohort Study and Systematic Review
Authors: Swisher Austin R. , Landau Mark J. , Kadakia Nikita , Holzmer Stephanie W. , Kim Hahns Y. 
Published: June 2022

Background:
Acellular dermal matrices (ADMs) are commonly used in tissue expander and direct-to-implant reconstruction following mastectomy. Few studies have reported outcomes of DermACELL use or compared DermACELL with AlloDerm ADM. This study sought to compare outcomes of DermACELL and AlloDerm in oncologic breast reconstruction and to review the literature reporting outcomes of patients undergoing reconstruction using DermACELL.

Methods:
We conducted a retrospective cohort study to compare outcomes between DermACELL and AlloDerm ADM, and a systematic review of the literature with a meta-analysis to evaluate clinical outcomes with DermACELL.

Results:
Seventy-four patients (128 breasts) undergoing immediate reconstruction were evaluated retrospectively. Chi-square analysis revealed no significant difference in postoperative outcomes between the two groups. Our systematic review of the literature yielded 12 total studies reporting DermACELL use for breast reconstruction encompassing 518 patients and 608 total breasts. A pooled analysis of the published data did not reveal a significant change in the rate of explantation when either chemotherapy or radiation was used. Meta-analysis did not show a significant difference in the rate of any of the complications evaluated.

Conclusion:
DermACELL is safe to use with a relatively consistent complication profile as compared with AlloDerm.