bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erfahrungen aus dem Rückbau der Brücke am Altstädter Bahnhof in der Stadt Brandenburg – Teil 2: Schadensmonitoring bei zerstörenden Versuchen
Authors: Pirskawetz Stephan , Steinbock Oliver , Hille Falk , Schmidt Sebastian , Hofmann Detlef 
Published: July 2022

AbstractIm Dezember 2019 wurden bei einer turnusmäßigen Inspektion der B 1‐Brücke am Altstädter Bahnhof in Brandenburg an der Havel massive und schnell voranschreitende Schäden festgestellt. Als Ursache für die Risse entlang der Längsträger wurde das Versagen eines signifikanten Anteils der Spanndrähte der konzentrierten Spannglieder vermutet. Die Brücke wurde umgehend für den Verkehr gesperrt und im Mai 2021 gesprengt. Im Vorfeld der Sprengung wurden durch das Bundesministerium für Digitales und Verkehr (BMDV) weiterführende Untersuchungen zum Schadensbild veranlasst, welche vom Landesbetrieb Straßenwesen Brandenburg koordiniert und in den Bauablauf integriert wurden. Das von der Hochschule für Technik und Wirtschaft (HTW) Dresden erstellte Versuchskonzept ist Bestandteil des vorangestellten ersten Teils des Beitrags [1]. Hier im zweiten Teil werden ausgewählte Ergebnisse der umfangreichen versuchsbegleitenden Mess‐ und Monitoringmaßnahmen beschrieben, welche in Kooperation der HTW Dresden, der Bilfinger Noell GmbH sowie der Bundesanstalt für Materialforschung und ‐prüfung (BAM) durchgeführt wurden.
Synthesis, Molecular Docking and Biological Evaluation of N‐Substituted Indole Derivatives as Potential Anti‐Inflammatory and Antioxidant Agents
Authors: Kumari Archana , Singh Rajesh Kumar 
Published: July 2022

AbstractNovel N‐substituted Indole derivatives with various hetero‐cyclic moieties were synthesized via an ethyl linker in order to obtain highly potent anti‐inflammatory and antioxidant agents. The structure of the obtained chemical compounds was determined using IR, 1H‐NMR, and mass spectroscopy. Molecular docking was used to create selective and efficient COX‐2 inhibitors from twelve novel indole derivatives (11a–c, 12a–c, 13a–c, and 14a–c). The compounds 13b and 14b had a high interaction energy, which inhibited the COX‐2 enzyme. There is a relationship between anti‐inflammatory activity and antioxidants, which is also defined by COX‐2 inhibition, according to the mechanism of action. The Swiss ADME online programme was used to determine the drug‐like properties of synthesized compounds. Two common and reliable methods were adopted to determine the antioxidant effect. In the DPPH assay, compounds 11a, 11b, and 14b, whereas compounds 11b, 13b, and 14b in the reducing power assay, were the most potent as compared with standard ascorbic acid. To evaluate the anti‐inflammatory effect at an acute and chronic level, the carrageenan‐induced paw edema method along with the formalin‐induced inflammation method were used both at low dose and high dose. From the collected results, compounds 13b and 14b were the most potent against acute and chronic inflammation. The results showed that the synthesized compounds are unique as anti‐inflammatory and antioxidant agents, and that they could be useful for drug discovery in the future.
Cu‐Catalyzed Chan–Evans–Lam Coupling Reactions of 2‐Nitroimidazole with Aryl Boronic Acids: An Effort toward New Bioactive Agents against S. pneumoniae
Authors: Raju Selvam , Sheridan Patrick E. , Hauer Alanna K. , Garrett Allyn E. , McConnell Danielle E. , Thornton Justin A. , Stokes Sean L. , Emerson Joseph P. 
Published: July 2022

AbstractThe coupling of phenylboronic acids with poorly‐activated imidazoles is studied as a model system to explore the use of copper‐catalyzed Chan–Evans–Lam (CEL) coupling for targeted C−N bond forming reactions. Optimized CEL reaction conditions are reported for four phenanthroline‐based ligand systems, where the ligand 4,5‐diazafluoren‐9‐one (dafo, L2) with 1 molar equivalent of potassium carbonate yielded the highest reactivity. The substrate 2‐nitroimidazole (also known as azomycin) has documented antimicrobial activity against a range of microbes. Here N‐arylation of 2‐nitroimidazole with a range of aryl boronic acids has been successfully developed by copper(II)‐catalyzed CEL reactions. Azomycin and a range of newly arylated azomycin derivatives were screened against S. pneumoniae, where 1‐(4‐(benzyloxy)phenyl)‐2‐nitro‐1H‐imidazole (3d) was demonstrated to have a minimal inhibition concentration value of 3.3 μg/mL.
Atrial functional mitral regurgitation: A cautionary tale?
Authors: Inci Errol , Block Peter C. 
Published: July 2022

Key Points
Approximately one‐third of patients with functional mitral regurgitation (FMR) have atrial FMR (A‐FMR) and need to be identified.
Transcatheter edge to edge repair (TEER) may benefit patients with A‐FMR.
Many unknowns remain concerning A‐FMR and TEER which require further investigation.
Lifetime management when a redo is in the balance
Authors: Alasnag Mirvat 
Published: July 2022

Key Points
Valve‐in‐valve transcatheter aortic valve replacement is associated with better short‐term outcomes, including all‐cause mortality, compared with redo surgical replacement.
As the adoption of valve‐in‐valve transcatheter aortic valve replacement continues to grow, it is critical to generate evidence for long‐term durability and survival.
The initial implant, whether surgical or transcatheter, is an important determinant of future options.
May FFR‐guided PCI save lives?
Authors: Di Serafino Luigi , Esposito Giovanni 
Published: July 2022

Key Points
PCI driven by a positive FFR value might be associated with a significant reduction in mortality rate in patients presenting with chronic coronary syndromes as compared with angiography alone
FFR should not be considered only for deferring but also for correctly indicating revascularization with PCI
Future randomized studies should focus on the impact of the appropriateness of PCI on clinical outcome
Those pesky anomalous coronary arteries: The importance of recognition before surgical repair of congenital cardiac disease and those mysterious Q waves
Authors: Patel Nachiket J. , Heuser Richard R. 
Published: July 2022

Key Points
Most infants with tetralogy of Fallot have staged surgical repairs of this complex congenital cardiac anomaly.
Coronary anomalies occur in a tetralogy about 5% of the time.
The most common coronary anomaly in the tetralogy of Fallot is an anomalous takeoff of the left anterior descending coronary artery of the right coronary artery which can be plicated during complete repair of the defect when the obstructed RV outflow tract is surgically opened.
Retrograde CTO PCI—the final frontier—challenges and outcomes
Authors: Kalyanasundaram Arun , Seth Ashok 
Published: July 2022

Key Points
Increasing operator experience and an algorithmic approach of transitioning to retrograde approach when antegrade technique fails, have improved the success rates in CTO PCI.
Upfront (Primary)retrograde approach is used in some cases with moderate success and the presence of usable collateral is the most important predictor of this.
While pursuing improved revascularization rates of CTO PCI, one should also keep in mind patient safety and complications rates.
Ticagrelor monotherapy after coronary stenting in patients requiring proton pump inhibitor and prolonged antiplatelet therapy
Authors: Ashley Kellan E. , Hillegass William B. 
Published: July 2022

Key Points
Approximately half of patients undergoing coronary stenting are discharged on a proton‐pump inhibitor (PPI).
Post‐hoc analysis of the large GLOBAL LEADERs trial finds PPI treatment and aspirin monotherapy after a year of dual antiplatelet therapy (DAPT) is associated with increased risk of ischemic events. In contrast, PPI treatment and continued ticagrelor monotherapy are not associated with increased ischemic events in the second year after stenting.
This observational evidence suggests the GLOBAL LEADERS tested ticagrelor monotherapy regimen could be considered in patients requiring both prolonged antiplatelet therapy (>12 months) and PPI for increased bleeding risk.
Angiographic predictors of aberrant circumflex artery during cardiac catheterization
Authors: Triantafyllis Andreas S. , van Nunen Lokien X. , Lesizza Pierluizi , Pagourelias Efstathios D. , Kalogeris Aimilianos , Bouwmeester Sjoerd , Tsinivizov Pavlos , Kontogiannis Nestoras , Giannakopoulos Andreas , Poulimenos Leonidas E. , Bennett Johan , Teeuwen Koen , Kyfnidis Konstantinos , Desmet Walter , Tonino Pim A. L. , McCutcheon Keir 
Published: July 2022

AbstractObjectivesTo identify angiographic predictors of aberrant left circumflex artery (LCx) by comparing left main (LM) length and bifurcation angle between patients with aberrant LCx and normal anatomy.BackgroundFailure to recognize aberrant LCx during a cardiac catheterization may hamper correct diagnosis, delay intervention in acute coronary syndromes, and result in increased contrast volume, radiation exposure, and infarct size.MethodsWe retrospectively analyzed angiograms of aberrant LCx patients and normal anatomy matched controls, in three‐participating centers. LM‐length, bifurcation angle between the left anterior descending (LAD) and the first non‐LAD branch of the LM, and procedural data were compared.ResultsBetween 2003 and 2020, 136 patients with aberrant LCx and 135 controls were identified. More catheters (2.4 ± 0.6 vs. 2.2 ± 0.9, p = 0.009), larger contrast volumes (169 ± 94 ml vs. 129 ± 68 ml, p < 0.0005), and prolonged fluoroscopy time (652.9 ± 623.7 s vs. 393.1 ± 332.1 s, p < 0.0005), were required in the aberrant LCx‐group compared with controls. Patients with aberrant LCx had a longer LM‐length and a more acute bifurcation angle, both in caudal and cranial views, compared with controls (24.7 ± 8.1 vs. 10.8 ± 4.5 mm, p < 0.0005 and 26.7 ± 7.4 vs. 12 ± 5.5 mm, p < 0.0005, respectively, and 45.2° ± 12° vs. 88.8° ± 23°, p < 0.0005 and 51.9° ± 21° vs. 68.2° ± 28.3°, p < 0.0005, respectively). In ROC analysis, LM‐length showed the best diagnostic accuracy for detecting aberrant LCx. In multiple logistic regression analysis, a cranially measured LM‐length > 17.7 mm was associated with a 5.3 times greater probability of predicting aberrant LCx [95% CI (3.4–8.1), p < 0.0001].ConclusionsOur study suggests that a long LM‐length and an acute bifurcation angle can indicate the presence of aberrant LCx. We present a practical algorithm for its rapid identification.
One‐Pot Synthesis of High‐Strained Metal Vinylidene and Metal Carbyne
Authors: Huang Fanping , Yan Zhewei , Zheng Xuejuan , Cai Yapeng , Zhang Hong , Xia Haiping 
Published: July 2022

AbstractA novel one‐pot reaction producing a metal vinylidene structure in a five‐membered ring by cyclization of a multiyne has been achieved. The ring strain and the high stability of the cyclic metal vinylidene complexes have been analyzed experimentally and computationally. The metal vinylidene unit in a fused‐ring complex is unreactive to both nucleophiles and electrophiles. It reacts however at the nearby carbonyl group achieving the unprecedented conversion of metal tributing factors for the aromaticity‐driven process has been studied by DFT calculations.
Interview with Prof. Dr. Benjamin List: Nobel Laureate in Chemistry 2021
Authors: Dilanas Melina E. A. , Dobbelaar Emiel , Gerischer Charlotte M. , Haseloer Alexander , John Torsten , Neumeier Claudia 
Published: July 2022

AbstractIn an interview with Benjamin List, winner of the 2021 Nobel Prize in Chemistry, members of the Young Chemists’ Network (JCF) of the German Chemical Society (GDCh) asked him about his science, his career, and the academic system. Benjamin List, Director at the Max‐Planck‐Institut für Kohlenforschung in Germany, was awarded the Nobel Prize together with David W. C. MacMillan (Princeton University, USA) for the development of asymmetric organocatalysis. After studying chemistry at the Free University of Berlin, he received his doctorate from Goethe University in Frankfurt. He discovered the amino acid proline to be an efficient catalyst and thus co‐founded the field of organocatalysis. In 2016, he received the Gottfried Wilhelm Leibniz Prize, which is considered the most important research award in Germany.
Deep Dive into Lattice Dynamics and Phonon Anharmonicity for Intrinsically Low Thermal Expansion Coefficient in CuS
Authors: Samanta Sudeshna , Gusain Meenakshi , Zhang Yiming , Zhan Yiqiang , Zhang Hao , Wang Lin , Xiong Shisheng 
Published: July 2022

AbstractScientists enquire about materials engineered with high nanoparticle densities with reduced thermal conductivity and excellent thermoelectric performance. An emerging mineral, copper sulfide (CuS) promises a novel paradigm in the proximity of pressure‐driven structural phase transitions to tune its functional and mechanical properties. Though CuS is a thermoelectric material with low lattice thermal conductivity (
), improvement of its
remains a challenge to be addressed. Moreover, the underlying mechanism governing pressure‐induced phase transformation and reasons for intrinsically small
remains completely unexplored. In this study, by combining in‐situ vibrational spectroscopy and ab initio calculations, we reveal that strong phonon anharmonicity under high pressure and low temperature demonstrates a promising approach to decreasing
efficiently and boosts thermoelectric figure of merit by 2.7 times from its ambient value. A large mode Grüneisen parameter and short lifetimes for acoustic phonons contribute significantly to its thermal transport.
Multifocal cutaneous angiosarcoma of the scalp—A challenging reconstructive case managed with skin substitutes
Authors: Messias Henrique , Martins Mariluz , Zagalo Carlos , Gomes Pedro 
Published: July 2022

AbstractBackgroundCutaneous angiosarcoma (AS) of the head and neck is a rare highly aggressive tumor, often associated with difficult local control of the disease and poor prognosis. This article describes a case of multifocal cutaneous AS of the scalp, mainly addressing its difficult surgical management and challenging reconstruction and concludes with a review of the literature.MethodsA 70‐year‐old Caucasian male was referred to our hospital with a growing scalp lesion initially suspected to be benign, but later diagnosed with AS.ResultsThe patient had tumor recurrence and a difficult reconstruction for which dermal substitutes proved very useful.ConclusionAS can mimic a benign lesion in its early stages. Skin substitutes, namely dermal templates, can be useful to meet the complex needs of reconstruction and oncological surveillance of patients with AS.
Gold–Hydrogen Analogy in Small–Sized Hydrogen–Doped Gold Clusters Revisited
Authors: Megha  , Mondal Krishnakanta , Ghanty Tapan K. , Banerjee Arup 
Published: July 2022

AbstractThe analogy between gold and hydrogen is a subject of long‐standing debate. In the present work, we examine the validity of the gold‐hydrogen analogy in a series of small‐sized H‐doped gold clusters, Aun−1H with n varying between 2 and 10 and also investigate its dependence on the cluster size. Keeping in mind the importance of the role of structures, we make use of the genetic algorithm coupled with a density functional theory based method to exhaustively search and identify the energetically low‐lying structures of each of the H‐doped gold clusters. These lower energy structures of H‐doped and pristine gold clusters are then employed to carry out the calculations of their electronic properties, stability analysis as well as their reactivity towards the adsorption and activation of CO and O2 molecules. Our study shows that in line with the gold‐hydrogen analogy, both electronic properties and the adsorption/activation characteristics of H‐doped gold clusters remain very similar to those of pristine gold clusters.
Validation of a noninvasive aMMP‐8 point‐of‐care diagnostic methodology in COVID‐19 patients with periodontal disease
Authors: Gupta Shipra , Mohindra Ritin , Singla Mohita , Khera Sagar , Kumar Amit , Rathnayake Nilminie , Sorsa Timo , Pfützner Andreas , Räisänen Ismo T. , Soni Roop K. , Kanta Poonam , Jain Akanksha , Gauba Krishan , Goyal Kapil , Singh Mini P. , Ghosh Arnab , Kajal Kamal , Mahajan Varun , Suri Vikas , Bhalla Ashish 
Published: July 2022

AbstractObjectivesThe aim of this study was to validate an active matrix metalloproteinase (MMP‐8) point‐of‐care diagnostic tool in COVID‐19 patients with periodontal disease.Subjects, Materials, and MethodsSeventy‐two COVID‐19‐positive and 30 COVID‐19‐negative subjects were enrolled in the study. Demographic data were recorded, periodontal examination carried out, and chairside tests run for evaluating the expression of active MMP‐8 (aMMP‐8) in the site with maximum periodontal breakdown via gingival crevicular fluid sampling as well as via a mouth rinse‐based kit for general disease activity. In COVID‐19‐positive patients, the kits were run again once the patients turned COVID‐19 negative.ResultsThe overall (n = 102) sensitivity/specificity of the mouthrinse‐based kits to detect periodontal disease was 79.41%/36.76% and that of site‐specific kits was 64.71%/55.88% while adjusting for age, gender, and smoking status increased the sensitivity and specificity (82.35%/76.47% and 73.53%/88.24, respectively). Receiver operating characteristic (ROC) analysis for the adjusted model revealed very good area under the ROC curve 0.746–0.869 (p < .001) and 0.740–0.872 (p < .001) (the aMMP‐8 mouth rinse and site‐specific kits, respectively). No statistically significant difference was observed in the distribution of results of aMMP‐8 mouth rinse test (p = .302) and aMMP‐8 site‐specific test (p = .189) once the subjects recovered from COVID‐19.ConclusionsThe findings of the present study support the aMMP‐8 point‐of‐care testing (PoCT) kits as screening tools for periodontitis in COVID‐19 patients. The overall screening accuracy can be further increased by utilizing adjunctively risk factors of periodontitis. The reported noninvasive, user‐friendly, and objective PoCT diagnostic methodology may provide a way of stratifying risk groups, deciding upon referrals, and in the institution of diligent oral hygiene regimens.
A new detailed loss model and design approach for LLC resonant converter with phase shift control to overall optimization of converter loss at whole battery charging process
Authors: Saadati Masoud , Ghayebloo Abbas 
Published: July 2022

AbstractThis paper proposes a new loss modeling and design method for phase shift controlled resonant LLC converter with optimization applied to minimize the overall loss during the whole battery charging process. In this work, the loss model has been formulated more accurately for phase shift controlled LLC converter. One of the contributions in accurate loss modeling is all switching modes of power switches have been investigated in detail in the aspect of zero voltage switching (ZVS) and ZCS occurrence and their related dynamic loss are updated in loss calculation during the whole charging process. In addition, to optimize the copper and core losses of high‐frequency transformer and resonant inductor, a design trend is included in optimization process to calculate the best physical dimensions and winding parameters of magnetic components. A genetic algorithm has been employed for the optimization during the charging process. In this work, the first harmonic approximation (FHA) model was developed and solved by nonlinear Newton–Raphson method in any operating point along one complete charging process. The target of optimization was designing a wall mounted type level 2 battery charger (7.4 kw/32A) for charging a battery pack with specs according to the Nissan Leaf 2011 electric vehicle. For verification of the proposed method, simulation results are provided and also experimental results for a low‐scale prototype are proposed. In this study, the average efficiency along the overall charging process obtained up to 95% in simulation and 84% in experiments.
In situ management options to improve crucian carp (Carassius carassius, L.) and brown trout (Salmo trutta, L.) population status in Central Europe: A case study from the Czech Republic
Authors: Lyach Roman 
Published: July 2022

AbstractThe crucian carp (Carassius carassius, L.) and the brown trout (Salmo trutta, L.) are vanishing from freshwater ecosystems of central Europe. To conserve both species, tailor‐made conservation management of habitats and populations of both species was implemented and tested in the Czech Republic (central Europe). This management was adjusted to reflect the ecological needs of both species. This study aimed to describe the results of a tested in situ management and to analyze the population growth of brown trout and crucian carp under ideal conditions. An experiment was performed at 14 small gravel pit lakes. Seven of them were adjusted to fit the crucian carp habitat requirements while the other seven were treated as a control group. The same experiment was done on 14 smaller streams and with brown trout. The occurrence and growth of crucian carp and brown trout were surveyed over 2 years. A significantly faster growth of both crucian carp and brown trout was observed on the adjusted lakes and streams in comparison to the control group ones. Trout and carp prospered on small streams and gravel pit lakes (respectively) that were free of angling, fish stocking, pollution, piscivorous predators, and competition with hybridizing species like Prussian carp (Carassius auratus, L.) or hatchery‐reared brown trout.
Pathways to the density‐dependent expression of cannibalism, and consequences for regulated population dynamics
Authors: Rosenheim Jay A. , Schreiber Sebastian J. 
Published: July 2022

AbstractCannibalism, once viewed as a rare or aberrant behavior, is now recognized to be widespread and to contribute broadly to the self‐regulation of many populations. Cannibalism can produce endogenous negative feedback on population growth because it is expressed as a conditional behavior, responding to the deteriorating ecological conditions that flow, directly or indirectly, from increasing densities of conspecifics. Thus, cannibalism emerges as a strongly density‐dependent source of mortality. In this synthesis, we review recent research that has revealed a rich diversity of pathways through which rising density elicits increased cannibalism, including both factors that (a) elevate the rate of dangerous encounters between conspecifics and (b) enhance the likelihood that such encounters will lead to successful cannibalistic attacks. These pathways include both features of the autecology of cannibal populations and features of interactions with other species, including food resources and pathogens. Using mathematical models, we explore the consequences of including density‐dependent cannibal attack rates on population dynamics. The conditional expression of cannibalism generally enhances stability and population regulation in single‐species models but also may increase opportunities for alternative states and prey population escape from control by cannibalistic predators.