bluuebunny/crossref_metadata_2025_split huggingface dataset:
Room-temperature polarization of individual nuclear spins in diamond via anisotropic hyperfine coupling and coherent population trapping
Authors: Jamonneau P. , Dréau A. , Hétet G. , Roch J. F. , Maze J. R. , Jacques V. 
Published: November 2022

Abstract
We employ the electronic spin of a single nitrogen-vacancy (NV) defect in diamond to detect and control the quantum state of remote nuclear spins coupled by hyperfine interaction. More precisely, our work focuses on individual $$^{13}\text {C}$$

13

C

nuclei featuring a moderate hyperfine coupling strength ($$\sim 1$$

∼
1

MHz) with the NV’s electron spin. Two different methods providing an efficient room-temperature polarization of these peculiar $$^{13}\text {C}$$

13

C

nuclear spins are described. The first one is based on a polarization transfer from the NV electron spin to the $$^{13}\text {C}$$

13

C

nucleus, which is mediated by the anisotropic component of the hyperfine interaction. The second one relies on coherent population trapping (CPT) within a $$\Lambda $$
Λ
-type energy-level configuration in the microwave domain, which enables to initialize the $$^{13}\text {C}$$

13

C

nuclear spin in any quantum state superposition on the Bloch sphere. This CPT protocol is performed in an unusual regime for which relaxation from the excited level of the $$\Lambda $$
Λ
-scheme is externally triggered by optical pumping and separated in time from coherent microwave excitations. For these two polarization techniques, we investigate the impact of optical illumination on the nuclear spin polarization efficiency. This work adds new methods to the quantum toolbox used for coherent control of individual nuclear spins in diamond, which might find applications in quantum metrology.

Graphical Abstract
On X-generalized skew derivations and their applications
Authors: De Filippis Vincenzo , Scudo Giovanni , Wei Feng 
Published: November 2022

Let [Formula: see text] be a prime ring of characteristic different from [Formula: see text], [Formula: see text] be its right Martindale quotient ring and [Formula: see text] be its extended centroid, [Formula: see text] be an automorphism of [Formula: see text], [Formula: see text] be a skew derivation of [Formula: see text] with associated automorphism [Formula: see text], [Formula: see text] and [Formula: see text] be two nonzero [Formula: see text]-generalized skew derivation of [Formula: see text] with associated term [Formula: see text] and [Formula: see text], respectively, [Formula: see text] be the set of the evaluations of [Formula: see text] on [Formula: see text], where [Formula: see text] is a non-central multilinear polynomial over [Formula: see text] in [Formula: see text] non-commuting variables. Let [Formula: see text] be such that [Formula: see text] for all [Formula: see text]. Then one of the following statements holds : (a) [Formula: see text] is central valued on [Formula: see text] and there exist [Formula: see text] such that [Formula: see text], [Formula: see text] for any [Formula: see text] with [Formula: see text]; (b) [Formula: see text] and [Formula: see text]. In the last part of the paper, we present some applications on the basis of the foregoing proposed result.
Scale-out Systolic Arrays
Authors: Yüzügüler Ahmet Caner , Sönmez Canberk , Drumond Mario , Oh Yunho , Falsafi Babak , Frossard Pascal 
Published: November 2022

Multi-pod systolic arrays are emerging as the architecture of choice in DNN inference accelerators. Despite their potential, designing multi-pod systolic arrays to maximize effective throughput/Watt—i.e., throughput/Watt adjusted when accounting for array utilization—poses a unique set of challenges. In this work, we study three key pillars in multi-pod systolic array designs, namely array granularity, interconnect, and tiling. We identify optimal array granularity across workloads and show that state-of-the-art commercial accelerators use suboptimal array sizes for single-tenancy workloads. We, then evaluate the bandwidth/latency trade-offs in interconnects and show that Butterfly networks offer a scalable topology for accelerators with a large number of pods. Finally, we introduce a novel data tiling scheme with custom partition size to maximize utilization in optimally sized pods. We propose
Scale-out Systolic Arrays
, a multi-pod inference accelerator for both single- and multi-tenancy based on these three pillars. We show that SOSA exhibits scaling of up to 600 TeraOps/s in effective throughput for state-of-the-art DNN inference workloads, and outperforms state-of-the-art multi-pod accelerators by a factor of 1.5 ×.

1
Associating Immunotherapy and Targeted Therapies: Facts and Hopes
Authors: Ladoire Sylvain , Rébé Cédric , Ghiringhelli François 
Published: November 2022

AbstractImmune-checkpoint inhibitors (ICI), particularly inhibitors of the PD-1/PD-L1 (Programmed Death 1/Programmed Death-Ligand 1) axis, have modified the management of many types of cancer over the last 10 years. However, both intrinsic and acquired resistance are major clinical issues with these therapies, and only a few patients are cured by ICI monotherapy. To overcome resistance, the concept of combining ICIs with other therapies is emerging and supported by many preclinical trials. Besides associations of ICIs with chemotherapy or radiotherapy, now used in clinical practice, some targeted therapies have also been reported to influence immune response of patients against cancer cells, thus showing potential synergy with ICIs. In this review, we describe the preclinical and clinical advances to date in the use of these combination strategies.
COMMD3-Mediated Endosomal Trafficking of HER2 Inhibits the Progression of Ovarian Carcinoma
Authors: Wang Shiqing , Liu Yuxin , Li Siyu , Chen Yanan , Liu Yanhua , Yan Jie , Wu Jiayi , Li Jia , Wang Longlong , Xiang Rong , Shi Yi , Qin Xuan , Yang Shuang 
Published: November 2022

AbstractThe dysregulated endocytic traffic of oncogenic receptors, such as the EGFR family especially HER2, contributes to the uncontrolled activation of the downstream oncogenic signaling and progression of various carcinomas, including 90% of ovarian carcinoma. However, the key regulators in the intracellular trafficking of HER2 and their impacts for cancer progression remain largely unknown. In this study, through a genome-wide CRISPR/Cas9 screening for key genes affecting the peritoneal disseminated metastasis of ovarian carcinoma, we identified a member of COMMD family, that is, COMMD3, as a key regulator in the endosomal trafficking of HER2. In the patients with high-grade serous ovarian carcinoma (HGSOC), the expression of COMMD3 is dramatically decreased in the peritoneal disseminated ovarian carcinoma cells comparing with that in the primary ovarian carcinoma cells. COMMD3 greatly inhibits the proliferation, migration, and epithelial–mesenchymal transition (EMT) of HGSOC cells, and dramatically suppresses the tumor growth, the formation of malignant ascites, and the peritoneal dissemination of cancer cells in the orthotopic murine model of HGSOC. Further transcriptome analysis reveals that silencing COMMD3 boosts the activation of HER2 downstream signaling. As a component in the Retriever-associated COMMD/CCDC22/CCDC93 complex responsible for the recognition and recycling of membrane receptors, COMMD3 physically interacts with HER2 for directing it to the slow recycling pathway, leading to the attenuated downstream tumor-promoting signaling.Implications:Collectively, this study reveals a novel HER2 inactivation mechanism with a high value for the clinic diagnosis of new ovarian carcinoma types and the design of new therapeutic strategy.
MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer
Authors: Yamashita Nami , Morimoto Yoshihiro , Fushimi Atsushi , Ahmad Rehan , Bhattacharya Atrayee , Daimon Tatsuaki , Haratake Naoki , Inoue Yuka , Ishikawa Satoshi , Yamamoto Masaaki , Hata Tsuyoshi , Akiyoshi Sayuri , Hu Qiang , Liu Tao , Withers Henry , Liu Song , Shapiro Geoffrey I. , Yoshizumi Tomoharu , Long Mark D. , Kufe Donald 
Published: November 2022

AbstractThe polybromo-1 (PBRM1) chromatin-targeting subunit of the SWI/SNF PBAF chromatin remodeling complex drives DNA damage resistance and immune evasion in certain cancer cells through mechanisms that remain unclear. STAT1 and IRF1 are essential effectors of type I and II IFN pathways. Here, we report that MUC1-C is necessary for PBRM1 expression and that it forms a nuclear complex with PBRM1 in triple-negative breast cancer (TNBC) cells. Analysis of global transcriptional (RNA-seq) and chromatin accessibility (ATAC-seq) profiles further demonstrated that MUC1-C and PBRM1 drive STAT1 and IRF1 expression by increasing chromatin accessibility of promoter-like signatures (PLS) on their respective genes. We also found that MUC1-C, PBRM1, and IRF1 increase the expression and chromatin accessibility on PLSs of the (i) type II IFN pathway IDO1 and WARS genes and (ii) type I IFN pathway RIG-I, MDA5, and ISG15 genes that collectively contribute to DNA damage resistance and immune evasion. In support of these results, targeting MUC1-C in wild-type BRCA TNBC cells enhanced carboplatin-induced DNA damage and the loss of self-renewal capacity. In addition, MUC1-C was necessary for DNA damage resistance, self-renewal, and tumorigenicity in olaparib-resistant BRCA1-mutant TNBC cells. Analysis of TNBC tumors corroborated that (i) MUC1 and PBRM1 are associated with decreased responsiveness to chemotherapy and (ii) MUC1-C expression is associated with the depletion of tumor-infiltrating lymphocytes (TIL). These findings demonstrate that MUC1-C activates PBRM1, and thereby chromatin remodeling of IFN-stimulated genes that promote chronic inflammation, DNA damage resistance, and immune evasion.Implications:MUC1-C is necessary for PBRM1-driven chromatin remodeling in chronic activation of IFN pathway genes that promote DNA damage resistance and immunosuppression.
Procedural Outcomes After Percutaneous Coronary Interventions in Focal and Diffuse Coronary Artery Disease
Authors: Mizukami Takuya , Sonck Jeroen , Sakai Koshiro , Ko Brian , Maeng Michael , Otake Hiromasa , Koo Bon‐Kwon , Nagumo Sakura , Nørgaard Bjarne L. , Leipsic Jonathon , Shinke Toshiro , Munhoz Daniel , Mileva Niya , Belmonte Marta , Ohashi Hirofumi , Barbato Emanuele , Johnson Nils P. , De Bruyne Bernard , Collet Carlos 
Published: November 2022

Background
Coronary artery disease (CAD) patterns play an essential role in the decision‐making process about revascularization. The pullback pressure gradient (PPG) quantifies CAD patterns as either focal or diffuse based on fractional flow reserve (FFR) pullbacks. The objective of this study was to evaluate the impact of CAD patterns on acute percutaneous coronary intervention (PCI) results considered surrogates of clinical outcomes.

Methods and Results

This was a prospective, multicenter study of patients with hemodynamically significant CAD undergoing PCI. Motorized FFR pullbacks and optical coherence tomography (OCT) were performed before and after PCI. Post‐PCI FFR >0.90 was considered an optimal result. Focal disease was defined as PPG >0.73 (highest PPG tertile). Overall, 113 patients (116 vessels) were included. Patients with focal disease were younger than those with diffuse CAD (61.4±9.9 versus 65.1±8.7 years,
P
=0.042). PCI in vessels with high PPG (focal CAD) resulted in higher post‐PCI FFR (0.91±0.07 in the focal group versus 0.86±0.05 in the diffuse group,
P
<0.001) and larger minimal stent area (6.3±2.3 mm
2
in focal versus 5.3±1.8 mm
2
in diffuse CAD,
P
=0.015) compared withvessels with low PPG (diffuse CAD). The PPG was associated with the change in FFR after PCI (
R
2
=0.51,
P
<0.001). The PPG significantly improved the capacity to predict optimal PCI results compared with an angiographic assessment of CAD patterns (area under the curve
PPG
0.81 [95% CI, 0.73–0.88] versus area under the curve
angio
0.51 [95% CI, 0.42–0.60];
P
<0.001).

Conclusions
PCI in vessels with focal disease defined by the PPG resulted in greater improvement in epicardial conductance and larger minimal stent area compared with diffuse disease. PPG, but not angiographically defined CAD patterns, distinguished patients attaining superior procedural outcomes.

Registration

URL:
https://clinicaltrials.gov/ct2/show/NCT03782688
Installation and monitoring of a canopy bridge connecting Atlantic Forest fragments containing endangered species in Northeastern Brazil
Authors: Buss Gerson , Ludwig Gabriela , Beltrão-Mendes Raone , Valença-Montenegro Mônica Mafra , Martins Amely Branquinho , Chein Alonso André 
Published: November 2022

Abstract
In 2019, a canopy bridge was built connecting two fragments of the Atlantic Forest separated by the Pacatuba unpaved road within the Pacatuba-Gargaú Corridor. This bridge was built as part of the Brazilian National Action Plan for the Conservation of Northeastern Primates (Plano de Ação Nacional para Conservação dos Primatas do Nordeste – PAN PRINE). The forest fragments contain a variety of mammal species, including the endangered primate species Alouatta belzebul and Sapajus flavius. Between September 2019 and March 2020, we monitored the canopy bridge continuously with a Bushnell camera trap; for a total of 204 days of sampling, resulting in evidence of 113 independent passage events. During the monitoring period, four mammal species used the canopy bridge, the Endangered Sapajus flavius (blond capuchin monkey), Callithrix jacchus (common marmoset), Marmosa demerarae (woolly mouse opossum), and Marmosa murina (murine mouse opossum). The common marmoset (Callithrix jacchus) used the bridge most frequently, representing 50.44% of the passage events (57), while the blond capuchin monkey (S. flavius) crossed the bridge in 30 events (26.5% of total crossings). All other mammals used the bridge less frequently than the primates (23% of crossings were of opossums). There was no record of crossings by the red-handed howler monkey (Alouatta belzebul) during the monitoring period. The construction of the canopy bridge within the Pacatuba-Gargaú forest corridor promoted structural and functional connectivity of the forest habitats, affecting the movement of the Endangered blond capuchin monkey and the common marmoset and benefiting other arboreal mammal species. The results indicate that monitoring the use of this canopy bridge provided important insights into the behaviour and ecology of the species studied (e.g., activity patterns, social interactions, group sizes, and reproduction, among many others). In addition, the use of the bridge decreases the risks of animal-vehicle collisions and electrocutions. Considering our results, we strongly recommend constructing and implementing canopy bridges as a strategy for the conservation of arboreal species living in fragmented forest areas.
A Multicenter Virtual Multidisciplinary Sarcoma Case Conference Improves Outcome for a Rare Soft Tissue Sarcoma (Dermatofibrosarcoma Protuberans)
Authors: Chang Amber L. , Kwak Hyunjee V. , Pan Minggui , Peng Peter D. , Morse Lee J. , Chang C.K. 
Published: November 2022

Introduction The purpose of this study is to analyze the impact of a virtual multidisciplinary sarcoma case conference (VMSCC) on the outcomes of dermatofibrosarcoma protuberans (DFSP). Methods We compared margin status after surgery and disease-free survival (DFS) on two cohorts of patients with DFSP, one diagnosed from 2010 to 2015 and one from 2016 to 2020 (before and after virtual multidisciplinary sarcoma case conference (VMSCC) within Kaiser Permanente Northern California (KPNC), using Kaplan-Meier curves and Cox proportional hazard regression models. Results There was no significant difference between the two cohorts on demographics, tumor location, type of surgery, receipt of radiation, receipt of imatinib, or size of tumor. However, the percent of patients with positive margin after final surgery and the percent of local recurrence were significantly different: 6.5% and 6.3% for the 2010-2015 cohort, and .8% and 0% for the 2016-2020 cohort, respectively. Conclusion Our data suggest that the outcomes of DFSP improved significantly after the implementation of VMSCC.
Breccia Hazards in the South Caspian Basin
Authors: Bagirov E. , Lerche I. 
Published: November 2022

Ejection of breccia from mud volcanoes for the onshore and offshore South Caspian Basin provides hazards for rigs, pipeline, and subsea completion equipment. Here we investigate the lateral ranges of ejected rock fragments for aeolian and submarine conditions. In addition, the consequences are considered of emission from a raised or depressed crater, with or without a surrounding crater wall. Also investigated is aeolian transport to an ocean surface, and subsea motion thereafter. Rough rules of thumb for aeolian hazards from breccia would indicate that seconds to tens of seconds after breccia emission is the onset time of hazard, with hazard distances typically of order a few hundred meters, but occasionally reaching about a kilometer or so for fairly large (5 kg) rocks emitted at high (∼500 m/s) speeds, with impact speeds of order 10–100 m/s. Submarine hazards yield 0.1-4 m/s impact speeds on the ocean floor for water depths in excess of about 2 m. For shallower water depths the aeolian impact speed is a good approximation. The hazard potential to equipment from breccia is one of concern, with a worst case distance estimate of about 1 km from the ejection point.
Simple changes to the reporting environment produce a large reduction in the frequency of interruptions to the reporting radiologist: an observational study
Authors: Banziger Carina , McNeil Kirsty , Goh Hui Lu , Choi Samantha , Zealley Ian A 
Published: November 2022

Background Interruptions are a cause of discrepancy, errors, and potential safety incidents in radiology. The sources of radiological error are multifactorial and strategies to reduce error should include measures to reduce interruptions. Purpose To evaluate the effect of simple changes in the reporting environment on the frequency of interruptions to the reporting radiologist of a hospital radiology department. Material and Methods A prospective observational study was carried out. The number and type of potentially disruptive events (PDEs) to the radiologist reporting inpatient computed tomography (CT) scans were recorded during 20 separate 1-h observation periods during both pre- and post-intervention phases. The interventions were (i) relocation of the radiologist to a private, quiet room, and (ii) initial vetting of clinician enquiries via a separate duty radiologist Results After the intervention there was an 82% reduction in the number of frank interruptions (PDEs that require the radiologist to abandon the reporting task) from a median 6 events per hour to 1 (95% confidence interval [CI] = 4–6; P < 0.00001). The overall number of PDEs was reduced by 56% from a median 11 events per hour to 5 (95% CI = 4.5–11: P < 0.00001). Conclusion Relocation of inpatient CT reporting to a private, quiet room, coupled with vetting of clinician enquiries via the duty radiologist, resulted in a large reduction in the frequency of interruptions, a frequently cited avoidable source of radiological error.
Comparing image quality of five breast tomosynthesis systems based on radiologists’ reviews of phantom data
Authors: Sundell Veli-Matti , Jousi Mikko , Mäkelä Teemu , Kaasalainen Touko , Hukkinen Katja 
Published: November 2022

Background Previous studies have shown differences in technical image quality between digital breast tomosynthesis (DBT) systems. However, quantitative image quality measurements may not necessarily fully reflect the clinical performance of DBT. Purpose To study the subjective image quality of five DBT systems manufactured by Fujifilm, GE, Hologic, Planmed, and Siemens using phantom images. Material and Methods A TOR MAM test object with polymethyl methacrylate plates was imaged on five DBT systems from different vendors. Three DBT acquisitions were performed at mean glandular doses of 1.0 mGy, 2.0 mGy, and 3.5 mGy while maintaining a constant phantom set-up. Eight DBT acquisitions with different test plate positions and phantom set-up thicknesses were performed at clinically applied dose levels. Additionally, three conventional two-dimensional mammogram images were acquired with different phantom thicknesses. Six radiologists ranked the systems based on the visibilities of the targets seen in the phantom images. Results In the DBT acquisitions performed at comparable dose levels, one system differed significantly from all other systems in microcalcification scores. When using site-specific DBT protocols, significant differences were found between the devices for microcalcification, filament, and low-contrast targets. A strong correlation was observed between the reviewer scores and radiation doses in DBT acquisitions, whereas no such correlation was observed in the 2D acquisitions. Conclusion In DBT acquisitions, dose level was found to be a major factor explaining image quality differences between the systems, regardless of other acquisition parameters. Most DBT systems performed equally well at similar dose levels.
The influence of leadership styles and supervisor communication on employee burnout
Authors: Xu Yifan , Farris Kristen 
Published: November 2022

The purpose of this study is to examine the communicative factors enacted by supervisors’ leadership, including supervisors’ perceived communication competence and workers’ communication satisfaction with their supervisors that predict employees’ feeling of burnout. Employees who were employed on a full-time basis for at least 1 year ( N = 166) completed a cross-sectional, online survey about interactions with their supervisors. Results from the path analysis indicated that both task- and relational-leadership were positively associated with communication competence. Only relational leadership was positively associated with communication satisfaction. In turn, communication satisfaction predicted decreased employee emotional exhaustion and depersonalization and increased personal accomplishment. Taken together, the findings from the current study suggest the importance of relationship-building between supervisors and employees to decrease employee burnout. Limitations and future research are addressed.