bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektivitas Media Sosial Akun Instagram @detikcom dalam Pemenuhan Kebutuhan Informasi
Authors: Puspita Nadia Ayu 
Published: September 2022

@detikcom adalah akun Instagram resmi detik.com yang merupakan sebuah web berisi berita dan artikel dalam jaringan di Indonesia. @detikcom membagikan kembali informasi yang telah dibagikan sebelumnya pada portal web berita detik.com pada halaman akun tersebut agar para followers dapat mengetahui perkembangan berita melalui beranda Instagram. Peneliti memilih followers aktif akun instagram @detikcom sebagai subjek penelitian karena terkait keaktifan mengikuti informasi akun tersebut, akan lebih besar kemungkinan informasi yang didapatkan. Penelitian_ini bertujuan untuk_mengetahui dan melihat adakah_pengaruh­_antara efektivitas dan penggunaan media sosial akun instagram @detikcom dengan pemenuhan kebutuhan informasi followersnya. Peneliti menggunakan pendekatan penelitian kuantitatif, dengan paradigma positivistik dan menggunakan metode survey. Pengumpulan data dalam penelitian ini yaitu dengan cara menyebarkan kuesioner kepada 385 responden yang dianggap representatif atau mewakili seluruh populasi penelitian. Teori_yang_digunakan peneliti_adalah_teori uses and gratification, dan kebutuhan informasi. Hasil menunjukan interpretasi nilai)koefisien_korelasi variabel efektivitas sebesar 0,786 berada pada rentang 0,60 – 0,799 yang menunjukan hubungan yang kuat dan variabel penggunaan media sosial sebesar 0,819 berada pada rentang 0,80 – 1,000 yang menunjukan hubungan yang sangat kuat. Pada uji F diperoleh Fhitung > Ftabel= 500,434 > 0,004 dengan nilai signifikansi 0.00 < 0.05 yang menunjukan arah pengaruh efektivitas dan penggunaan media sosial positif yang dapat berarti terdapat pengaruh_yang_signifikan_secara_parsial dan simultan terhadap pemenuhan kebutuhan informasi followers akun instagram @detikcom.
Conveying a fictional false belief in narrative
Authors: Tonér Signe 
Published: September 2022

Abstract
Narrative ability is an important life-skill and mature narrators do not only provide information about actions and events when telling a story but also include the motivations, emotions and beliefs experienced by protagonists. It is rare for young children to spontaneously explain the beliefs of story characters but the reasons are unclear. In the current study, frog story data from 143 Swedish children aged 4–6 showed that children’s level of explicitness in conveying a fictional false belief was associated with referential narrative ability and use of mental vocabulary, but not to the ability to formulate embedded propositions. Socioeconomic status predicted level of explicitness, whereas no associations were found to age, sex or being multilingual. Future work should examine narrative practices in preschool and in the home more closely, enabling improved support to provide children with equal opportunities.
Konsentrasi Hara N, P dan Hasil Panen pada Tumpangsari Jagung-Kedelai yang Ditambahkan Mikoriza dan Sumber Nutrisi di Lahan Kering Lombok Utara
Authors: Ulfa Nurmasasinta  , Wahyu Astiko  , Baiq Erna Listiana  
Published: September 2022

Penelitian ini bertujuan untuk mengetahui pengaruh interaksi konsentrasi hara N, P dan hasil pada tumpangsari jagung-kedelai yang ditambahkan nutrisi tanaman di lahan kering di Lombok Utara.Penelitian ini menggunakan metode ekspreimental dengan Rancangan Acak Kelompok (RAK) Faktorial dengan dua faktor, faktor pertama adalah Pupuk Hayati Mikoriza (M) yang terdiri dari 2 taraf yang terdiri atas M0 = tanpa mikoriza dan M1 = dengan mikoriza (1 ton/ha), dan faktor kedua adalah perlakuan sumber nutrisi (U) dengan 4 taraf yang terdiri atas U0 = tanpa penambahan unsur hara, U1 = dengan 100 % dosis pupuk anorganik saja (Jagung = urea 300 kg/ha dan Phonska 200 kg/ha, kedelai= 60 kg/ha Urea dan 120 kg/ha Phonska), U2 = dengan 100 % dosis pupuk kandang sapi saja (12 ton/ha) dan U3 = dengan 50 % dosis pupuk kandang sapi (6 t/ha) + 50 % dosis pupuk anorganik (Jagung = urea 150 kg/ha dan Phonska 100 kg/ha, kedelai= 30 kg/ha Urea dan 60 kg/ha Phonska). Dari kedua faktor diperoleh 8 kombinasi, masing-masing kombinasi diulang sebanyak 3 kali sehingga diperoleh 24 unit percobaan. Hasil penelitian menunjukkan perlakuan dengan penambahan 50 % dosis pupuk kandang sapi (6 t/ha) + 50 % dosis pupuk anorganik (Jagung = urea 150 kg/ha dan Phonska 100 kg/ha, kedelai= 30 kg/ha Urea dan 60 kg/ha Phonska) memberikan aktivitas mikoriza, status hara dan hasil tanaman jagung dan kedelai terbaik.
PERAN KADER KAMPUNG KB PADA MASA PANDEMI COVID 19
Authors: Subekti Aditya Farit 
Published: September 2022

Kampung KB is an integrated development program population, family planning, as well as related sector development in an effort to improve quality of life for families and communities. Kampung KB’s cadres, are volunteers who are chosen to help organize population and family planning programs. This study knowing aims to role of kb village cadres in socializing preganancy distance arrangements during Pandemic. type of this research is descriptive This research is classified as using a qualitative research design. informants in this research amounted to 4 representative cadres of each RW chosen by Key Person. data collection in this research used a source triangulation technique with in-depth interviews and activity documentation. Results research are characteristics Kampung KB’s cadres in Tegaren Village are quite good, supported by self-motivation, as well support from local community and religious leaders, although in this case there are no binding rules to help performance of cadres. In addition, it is known that even during pandemic, cadres still continue to socialize and education community by door to door to help regulate distance between pregnancies in community. conclusion in this research is cadres continue to carry out their duties to socialize pregnancy distance and use of contraceptives as well as health monitoring community by door to door. In research, it is recommended for cadres to further increase their resource potential.
Chemical composition, physicochemical evaluation and sensory analysis of yogurt added with extract of polyphenolic compounds from Quercus crassifolia oak bark
Authors: Valencia-Avilés Eréndira , García-Pérez Martha Estrella , Garnica-Romo Ma. Guadalupe , Figueroa-Cárdenas Juan de Dios , Paciulli Maria , Martinez-Flores Hector Eduardo 
Published: September 2022

Introduction: A diet high in calories and saturated fats has been associated with health problems that have been increasing worldwide. Therefore, it is required to increase the number of formulated foods that generate well-being to health. Yogurt is a widely consumed food by all sectors of the population and it can be used as a vehicle to incorporate bioactive compounds. The phenolic compounds present in forest residues, such as those from oak bark, can be used and incorporated into yogurt, to increase its benefits as a functional food.Objective: The objective of this study was to develop a multifunctional yogurt enriched with vegetable oil (2.3% w/w) as a source of omega 6 and 3 and adding nanocapsules (24.5% w/w) of an extract of oak bark from Quercus crassifolia, rich in in phenolic compounds and high antioxidant capacity.Methods: Three yogurt formulations were prepared: F1: yogurt was made with non-fat milk, used as a control, F2: yogurt was prepared with non-fat milk and added with vegetable palm oil, and F3: non-fat yogurt was added with vegetable oil and nanoencapsulated oak bark phenolic extract. The yogurts were characterized in their chemical composition, microbiological analysis, and sensory analysis. Results: The multifunctional product F3 and product F2 presented lactic acid bacteria in concentration of 3.01X106 and 4.73x106, respectively, preserving characteristics of probiotic food. Product F3 presented low levels of syneresis (7.34%) and it was significantly different from the control yogurt (9.01%). The viscosity increased from 150 cP in the control yogurt to 341 cP in F3, due to the increase in the concentrations of solids by nanoencapsulating the phenolic. The wall material used for nanoencapsulation was sodium caseinate and mantodextrin. However, this increase in viscosity did not affect the sensory evaluation of the product. There were no significant differences between the control yogurt and the F2 and F3 products.Conclusion: A yogurt added with vegetable oil and nanoencapsulated oak bark phenolic extract was obtained. It was enhanced by the presence of probiotics, bioactive compounds, and essential fatty acids, and then evaluated and accepted by a sensory panel. Nanoencapsulation is a viable alternative to mask the characteristic astringent taste of phenolic compounds because it was not detected by the panelists. Keywords: waste recovery; functional dairy foods; essential fatty acids; probiotics; antioxidants; sensory.
Public Health Assurance in the COVID-19 Era: Current Challenges and Future Prospects
Authors: Enitan Seyi Samson 
Published: September 2022

If there is no any other time the subject of public health assurance should be discussed and taken more seriously, it is now, the COVID-19 ERA. The sudden outbreak of the COVID-19 pandemic in Wuhan province of China in December, 2019 has had tremendous impacts on various aspects of life across the world, including the health, economy, education and scientific research. Historically, public health has been a silver bullet for combating infectious diseases. The COVID-19 pandemic however, has further brought the need for public health assurance under global spotlight. Public Health Assurance covers those activities that deal with making sure people's health needs are safely and effectively met. Key areas of public health assurance include: 1) Enforcing laws and regulations that protect environmental health and ensure safety, 2) Linking people to needed environmental health services and assure the provision of environmental health services when otherwise unavailable, 3) Assuring a competent environmental health workforce, 4) Evaluating effectiveness, accessibility, and quality of personal and population-based environmental health services and 5) Researching for new insights and innovative solutions to environmental health problems. Challenges facing public health assurance include: 1) Inability to adequately perform the crucial public health tasks of evaluation, policy creation, and service assurance, 2) haphazard decision-making without the appropriate information and understanding, 3) Inequities in service provision and the advantages of public health, 4) Limitations on effective leadership, such as inadequate ties with the medical community and poor communication between the technical and political sides of decisions, inadequate creation of the knowledge required to address the full spectrum of public health demands, 6) Inadequate funding to support the delivery of public health services, and 7) public health workforce is understaffed and unequipped to meet the needs of local communities. COVID-19 has been and remains an unprecedented global crisis and public health systems have put tremendous efforts to withstand the pandemic with public health assurance.

_KEY WORDS: COVID-19, Public Health Assurance, Challenges, Prospects_
Analisis Yuridis Terhadap Perlindungan Hukum Profesi Dokter Dalam Penyelesaian Sengketa Medis
Authors: Siregar Boy , Sahari Alpi , Fauzi Ahmad 
Published: September 2022

Pembuktian seorang pecandu dan korban penyalahgunaan narkotika untuk direhabilitasi terbilang cukup sulit sebagaimana diatur dalam Undang-undang Nomor 35 Tahun 2009 tentang Narkotika, merupakan hal yang sulit, karena harus melihat awal pengguna narkotika menggunakan narkotika dan diperlukan pembuktian bahwa pengguna narkotika ketika menggunakan narkotika dalam kondisi dibujuk, diperdaya, ditipu, dipaksa, dan/atau diancam untuk menggunakan narkotika. Dalam implementasinya Mahkamah Agung mengeluarkan terobosan dengan mengeluarkan Surat Edaran (SEMA) Nomor 04 Tahun 2010 yang menjadi pegangan pertimbangan hakim dalam memutus narkotika. 2. Pemikiran Double Track System menginginkan adanya kesetaraan antara Sanksi Pidana dan sanksi tindakan, tentu saja ini sangat perlu diterapkan bagi pelaku penyalahgunaan narkotika sekaligus sebagai pecandu narkotika, sehingga tentu saja ada efek jera dan proses penyembuhan dari pelaku kejahatan narkotika tersebut dapat berjalan, sehingga bagi para pelaku kejahatan narkotika dan dengan proses ini dilksanakan akan mampu untuk sembuh dari ketergantungan penggunaan Narkotika dan jera karena adanya sanksi pidana. Namun jika korban penyalahgunaan narkotika hanya perlu diberikan tindakan penyembuhan/rehabilitasi dari pemerintah.
KAJIAN HUKUM TERHADAP ORANG DISABILITAS YANG MENGGUNAKAN NARKOTIKA DALAM PRESFEKTIF KRIMINOLOGI (STUDI DI POLRESTABES MEDAN)
Authors: Taufik Harahap Asrul , Ediwarman Ediwarman , Eddy Triono 
Published: September 2022

. Penyalahgunaan narkotika oleh penyandang disabilitas semakin merusak mental maupaun fisiknya, oleh karena itu perlu perhatian khusus dan tindakan kebijakan hukum dalam menghadapi dan menyelesaikan permasalahan ini agar tidak berkelanjutan. Untuk mengetahui penyebab terjadinya penyandang disabilitas menggunkan narkoba maka diperlukan penelitian mengenai faktor-faktornya dan akibat hukum apa yang akan terjadi bagi penyandang disabilitas tersebut. Hal ini akan ditinjau berdasarkan Undang-Undang No. 35 Tahun 2009 tentang Narkotika dan Undang-Undang No. 8 Tahun 2016 tentang Penyandang Disabilitas Peneliitan ini dilakukan dengan metode penelitian deskriptif analisis, metode pendekatan yang digunakan ialah pendekatan undang-undang dan pendekatan konseptual. Teknik pengumpulan data bersumber dari library research dan field research di Polresrtabes Kota Medan dan Institusi Penerima Wajib Lapor (IPWL) Pusat Rehabilitas Korban Narkoba Mari Indonesia Bersinar, kemudian data tersebut dianalisis secara kualitatif. Berdasarkan hasil penelitian maka diketahui bahwa faktor-faktor penyhalahgunaan narkoba terhadap penyandang disabilitas ialah faktor kepribadian, keluarga, pendidikan, lingkungan dan ekonomi dan tidak percaya diri. Dampak dari penyalahgunaan narkotika oleh penyandang disabilitas bagi lingkungan masyarakat yaitu dampaknya sangat luas dan merupaakan ancaman serius terhadap berbagai aspek kehidupan dan kelangsungan hidup bangsa dan negara, masyarakat juga merasa terganggu dan terkait keluarganya mempengaruhi oleh pengguna narkotika tak terkecuali terhadap penyandang disabilitas. Upaya yang dilakukan Polrestabes Kota Medan dalam melakukan pencegahan dan penanggualangan narkotika ialah melakukan giat rutin GKN (Grebek Kampung Narkoba), melaksanakan penyuluhan secara rutin di wilayah rawan markoba, melakukan giat gotong royong di wilayah rawan narkoba, mengembangkan program Bersinar (Bersih Narkoba). Mendaftarkan diri atau korban ke Institusi Penerima Wajib Lapor (IPWL) Pusat Rehabilitas Korban Narkoba Mari Indonesia Bersinar sebagai wadah pemulihan. Polrestabes Kota Medan agar segera melakukan sosialisasi dan edukasi kepada masyarakat terakit hal tersebut agar tidak terjadi.
Biomimetic, mussel-inspired surface modification of 3D-printed biodegradable polylactic acid scaffolds with nano-hydroxyapatite for bone tissue engineering
Authors: Chi Minghan , Li Na , Cui Junkui , Karlin Sabrina , Rohr Nadja , Sharma Neha , Thieringer Florian M. 
Published: September 2022

Polylactic acid (PLA) has been widely used as filaments for material extrusion additive manufacturing (AM) to develop patient-specific scaffolds in bone tissue engineering. Hydroxyapatite (HA), a major component of natural bone, has been extensively recognized as an osteoconductive biomolecule. Here, inspired by the mussel-adhesive phenomenon, in this study, polydopamine (PDA) coating was applied to the surface of 3D printed PLA scaffolds (PLA@PDA), acting as a versatile adhesive platform for immobilizing HA nanoparticles (nHA). Comprehensive analyses were performed to understand the physicochemical properties of the 3D-printed PLA scaffold functionalized with nHA and PDA for their potent clinical application as a bone regenerative substitute. Scanning electron microscopy (SEM) and element dispersive X-ray (EDX) confirmed a successful loading of nHA particles on the surface of PLA@PDA after 3 and 7 days of coating (PLA@PDA-HA3 and PLA@PDA-HA7), while the surface micromorphology and porosity remain unchanged after surface modification. The thermogravimetric analysis (TGA) showed that 7.7 % and 12.3% mass ratio of nHA were loaded on the PLA scaffold surface, respectively. The wettability test indicated that the hydrophilicity of nHA-coated scaffolds was greatly enhanced, while the mechanical properties remained uncompromised. The 3D laser scanning confocal microscope (3DLS) images revealed that the surface roughness was significantly increased, reaching Sa (arithmetic mean height) of 0.402 μm in PLA@PDA-HA7. Twenty-eight days of in-vitro degradation results showed that the introduction of nHA to the PLA surface enhances its degradation properties, as evidenced by the SEM images and weight loss test. Furthermore, a sustainable release of Ca2+ from PLA@PDA-HA3 and PLA@PDA-HA7 was recorded, during the degradation process. In contrast, the released hydroxyl group of nHA tends to neutralize the local acidic environments, which was more conducive to osteoblastic differentiation and extracellular mineralization. Taken together, this facile surface modification provides 3D printed PLA scaffolds with effective bone regenerative properties by depositing Ca2+ contents, improving surface hydrophilicity, and enhancing the in-vitro degradation rate.
The role of RNA m6A methylation in lipid metabolism
Authors: Wang Yuting , Wang Yujie , Gu Jiarui , Su Tianhong , Gu Xiaosong , Feng Yu 
Published: September 2022

The m6A methylation is the most numerous modification of mRNA in mammals, coordinated by RNA m6A methyltransferases, RNA m6A demethylases, and RNA m6A binding proteins. They change the RNA m6A methylation level in their specific manner. RNA m6A modification has a significant impact on lipid metabolic regulation. The “writer” METTL3/METTL14 and the “eraser” FTO can promote the accumulation of lipids in various cells by affecting the decomposition and synthesis of lipids. The “reader” YTHDF recognizes m6A methylation sites of RNA and regulates the target genes’ translation. Due to this function that regulates lipid metabolism, RNA m6A methylation plays a pivotal role in metabolic diseases and makes it a great potential target for therapy.
Basal insulin intensification with GLP-1RA and dual GIP and GLP-1RA in patients with uncontrolled type 2 diabetes mellitus: A rapid review of randomized controlled trials and meta-analysis
Authors: Lisco Giuseppe , De Tullio Anna , Disoteo Olga , De Geronimo Vincenzo , Piazzolla Giuseppina , De Pergola Giovanni , Giagulli Vito Angelo , Jirillo Emilio , Guastamacchia Edoardo , Sabbà Carlo , Triggiani Vincenzo 
Published: September 2022

Tirzepatide, a dual agonist of Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide 1 (GLP-1) receptors, improved glucose control and reduced body weight in different therapeutic approaches. Herein, we overviewed the role of GIP and GLP-1 in the pathophysiology of type 2 diabetes and systematically reviewed the efficacy and safety of injectable incretin-based therapy added to basal insulin in light of the results of the SURPASS-5 trial. We identified eleven randomized clinical trials. GLP-1 receptor agonists (GLP-1RAs) or Tirzepatide added to basal insulin than rigorously titrated basal insulin significantly ameliorates glucose control (Δ HbA1c = -1%, 95% CI -1.25; -0.74, I2 94%; Δ FPG = -14.6 mg/dL, 95% CI -21.6-; -7.6, I2 90%; chance to achieve HbA1c &lt;7% = RR 2.62, 95% CI 2.10; 3.26, I2 89%), reduces body weight (Δ = -3.95 kg, 95% CI -5.1, -2.79, I2 96%) without increasing the risk of hypoglycemia (RR = 1.01, 95% CI 0.86; 1.18, I2 7.7%). Tirzepatide provides an impressive weight loss exceeding that observed with GLP-1RAs. Injectable incretin-based therapy plus basal insulin remains a potent and safe therapeutic approach in uncontrolled type 2 diabetes patients previously treated with basal insulin alone. Tirzepatide is expected to ameliorate the management of “diabesity” in this usually difficult-to-treat cluster of patients.
Analysis of HIF2α polymorphisms in infertile women with polycystic ovary syndrome or unexplained infertility
Authors: Zheng Xiaoya , Ma Jiani , Hu Min , Long Jian , Wei Qiang , Ren Wei 
Published: September 2022

ObjectiveTo evaluate HIF2α polymorphisms and glucose metabolism in a group of women with polycystic ovary syndrome (PCOS) or unexplained infertility (UI).PatientsThe infertile group (n=148) consisted of 96 women with PCOS, 52 women with UI, and176 women without infertility as a healthy control group.InterventionWe genotyped 29 single nucleotide polymorphisms (SNPs) of HIF2α by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)-based genotyping technology. The genetic associations were analyzed statistically.Main outcome measuresAllele frequency, genotype distribution and haplotype analyze of the HIF2α polymorphisms were performed. Body mass index (BMI), waist circumference, uric acid (UA), high-sensitivity C-reactive protein (hsCRP), lipids, glucose and insulin tolerance - were also measured.ResultsInfertile women with PCOS had a higherBMI and waist circumference, elevated hsCRP and uric acid (UA) levels, impaired glucose tolerance, and increased levels of plasma insulin compared to UI patients and healthy women. SNP analysis of HIF2α revealed that the allele and genotype frequencies of rs4953361 were significantly associated with infertile women with PCOS. Haplotype analysis of the HIF2α polymorphism identified haplotypes TGG and TGA as being associated with infertile women with PCOS. Women with the AA genotype of rs4953361 had a significantly higher BMI and post load plasma glucose and insulin levels than those of women with the GG genotype.ConclusionInfertile women with PCOS more commonly have metabolic disturbances than those with UI. This is the first study to report an association between HIF2α polymorphisms (rs4953361) and the risk of infertile women with PCOS, not UI, in Han Chinese population. These results require replication in larger populations.In this observational study, we did not report the results of a health care intervention on human participants. The study was approved by the Human Research Ethics Committee of the First Affiliated Hospital of Chongqing Medical University. Clinical data and peripheral blood samples were collected only after explaining the objectives of the study and obtaining a signed informed consent form.