bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of palliative care on medication: results of a retrospective analysis of 10,464 outpatients in Germany
Authors: Loosen Sven H. , Schwartz Jacqueline , Grewe Steven , Krieg Sarah , Krieg Andreas , Luedde Tom , Batzler Yann-Nicolas , Kostev Karel , Neukirchen Martin , Roderburg Christoph 
Published: November 2022

Abstract
Background
According to § 27 and § 87 1b of the German Social Code, Book V, outpatient palliative care (OPC) aims to promote, maintain, and improve the quality of life and self-determination of seriously ill people. It should enable them to live in dignity until death in their preferred environment. Instead of a curative approach OPC treatment focuses on the multiprofessional objective of alleviating symptoms and suffering on a case-by-case basis using medication or other measures, as well as the management of an individual treatment plan. The aim of this study was therefore to investigate to what extent medication differs from 12 months prior OPC treatment within 12 months following OPC treatment.
Methods
A retrospective database cross sectional study based on the IQVIA Disease Analyzer (DA) was performed, including adult patients with cancer diagnosis and at least one documentation of palliative support between January 1st, 2018 and December 31st, 2021, in 805 general practices (GP).
Results
The results of this study show, that in the context of OPC, there is a significant increase in the prescription of opioids (37.7% vs. 18.3%), sedatives (16.2% vs. 7.8%) and antiemetics (9.7% vs. 5.3%), as well as a significant reduction in other medications such as statins (21.4% vs. 11.5%), proton pump inhibitors (PPI) (41.2% vs. 35.3%), or antihypertensives (57.5% vs. 46.6%).
Conclusions
Our results support the role of OPC as an important element in improving pharmacological symptom control and deprescription to improve quality of life of patients at the end of their life.
Pre-hospital and intrahospital workflow optimization for patients with suspected ischemic stroke due to large vessel occlusion
Authors: Krebs Stefan , Ferrari Julia , Schürer Alice , Chiari Astrid , Neumann Christian , Lang Wilfried , Sykora Marek 
Published: November 2022

Abstract
Background
The efficacy of recanalization treatment in patients with ischemic stroke due to large vessel occlusion (LVO) is highly time dependent. We aimed to investigate the effects of an optimization of prehospital and intrahospital pathways on time metrics and efficacy of endovascular treatment in ischemic stroke due to LVO.
Methods
Patients treated with mechanical thrombectomy (MT) at the Hospital of St. John of God Vienna, Austria, between 2013 and 2020 were extracted from the Austrian Stroke Unit Registry. Study endpoints including time metrics, early neurological improvement and functional outcome measured by modified Rankin Scale (mRS) at 3 months were compared before and after optimization of prehospital and intrahospital pathways.
Results
299 patients were treated with MT during the study period, 94 before and 205 after the workflow optimization. Workflow optimization was significantly associated with time metrics improvement (door to groin puncture time 45 versus 31 minutes; p<0.001), rates of neurological improvement (NIHSS≥8: 30 (35%) vs. 70 (47%), p=0.04) and radiological outcome (TICI≥2b: 71 (75%) versus 153 (87%); p=0.013). Functional outcome (mRS 0-2: 17 (18%) versus 57 (28%); p=0.067) and mortality (34 (37%) versus 54 (32%); p=0.450) at 3 months showed a non-significant trend favoring the later time period group.
Conclusion
The implementation of workflow optimization was associated a significant reduction of intrahospital time delays and improvement of neurological and radiological outcomes.
A C57BL/6 Mouse model of SARS-CoV-2 infection recapitulates age- and sex-based differences in human COVID-19 disease and recovery
Authors: Davis Michael , Voss Kathleen , Turnbull J. Bryan , Gustin Andrew T. , Knoll Megan , Muruato Antonio , Hsiang Tien-Ying , Dinnon III Kenneth H. , Leist Sarah R. , Nickel Katie , Baric Ralph S. , Ladiges Warren , Akilesh Shreeram , Smith Kelly D. , Gale Michael 
Published: November 2022

Abstract
We present a comprehensive analysis of SARS-CoV-2 infection and recovery in wild type C57BL/6 mice, demonstrating that this is an ideal model of infection and recovery that accurately phenocopies acute human disease arising from the ancestral SARS-CoV-2. Disease severity and infection kinetics are age- and sex-dependent, as has been reported for humans, with older mice and males in particular exhibiting decreased viral clearance and increased mortality. We identified key parallels with human pathology, including intense virus positivity in bronchial epithelial cells, wide-spread alveolar involvement, recruitment of immune cells to the infected lungs, and acute bronchial epithelial cell death. Moreover, older animals experienced increased virus persistence, delayed dispersal of immune cells into lung parenchyma, and morphologic evidence of tissue damage and inflammation. Parallel analysis of SCID mice revealed that the adaptive immune response was not required for recovery from COVID disease symptoms nor early phase clearance of virus but was required for efficient clearance of virus at later stages of infection. Finally, transcriptional analyses indicated that induction and duration of key innate immune gene programs may explain differences in age-dependent disease severity. Importantly, these data demonstrate that SARS-CoV-2-mediated disease in C57BL/6 mice accurately phenocopies human disease across ages and establishes a platform for future therapeutic and genetic screens for not just SARS-CoV-2 but also novel coronaviruses that have yet to emerge.
Is a bio-psychosocial approach model possible at the first level of health services in the Democratic Republic of Congo? An organizational analysis of six health centers in South Kivu
Authors: Molima Christian Eboma Ndjangulu , Karemere Hermès , Makali Samuel , Bisimwa Ghislain , Macq Jean 
Published: November 2022

Abstract
Background
Health system, in Democratic Republic of Congo, is expected to move towards a more people-centered form of healthcare provision by implementing biopsychosocial (BPS) approach. It’s then important to examine how change are possible in providing healthcare at first line of care.
On the initial value of PageRank
Authors: Deyasi Krishanu 
Published: November 2022

Abstract
PageRank is used by Google for ranking web pages to present search results for a user query.
Here, we have shown that the PageRank of a vertex depends on its initial value which is also known as an intrinsic, non-network contribution. We analytically proved that PageRank value of vertices become proportional to their degrees if the intrinsic, non-network contributions of the vertices are proportional to their degrees or zeros. Simulated and empirical data are used to support our study. In addition, we have shown that localization of
PageRank depends on the intrinsic, non-network contribution.
Interval harvests changes phytochemical traits and biological activities of elite transformed hairy root cultures of African geranium (Pelargonium sidoides DC.)
Authors: Yousefian Zeynab , Hamidoghli Yousef , Golkar Pooran , Mirjalili Mohammad Hossein 
Published: November 2022

Abstract
Tuberous roots of African geranium (Pelargonium sidoides DC.) with modern ethanolic formulation called EPs 7630 (Umckaloabo) have widely used in medicinal industries. The present study was aimed to explore changes in the phytochemical traits (i.e., phenolics, flavonoids, coumarins and hydroxycinnamic acid derivatives), protein content, enzymatic-antioxidants and antimicrobial activities of several high-yielding hairy root lines (HRLs) of P. sidoides harvested at different times. Among all HRLs, antioxidative responses (e.g., phenylalanine ammonia lyase, polyphenol oxidase and catalase contents) were increased in HRL10 exposed to higher interval harvests. Moreover, HRL10 exhibited a promising antimicrobial effect against Escherichia coli, with MIC equal to (2.61 mg/ml). In total 10 phytochemical compounds were identified through chromatographic (HPLC) technique including: umckalin (Um), gallic acid (GA), quercetin (QE), luteolin (LU) and the others. The extraction of HRs had high content of Um at 21 days (0.35 𝜇g/ml). The maximal phenolic yield in particular GA was enhanced to (5194.5 𝜇g/ml), about 10-fold in comparison with non-transformed roots (516 𝜇g/ml) on the 35th day. HRs were able to produce the maximum improvement in flavonoid glycosides (13.96 𝜇g QE/ml and 23.75 𝜇g LU/ml) at the end of culture period. The most profitable transgenic lines offers an interesting option to enhance the productivity. These results support the in vitro cultivation of HRs for supply as a natural product to prevent inflammation and microbial related disorders.
A Multimodal-biometric Identification System Based on Deep Features to Identify Individuals
Authors: Akbari Mehdi , darooei shahram 
Published: November 2022

Abstract
With the growth of new technologies, biometric-based identification has been considered as an efficient method for automatic identification of individuals due to its unique nature and inability to forge it. Recently, researchers have used a combination of several different biometrics to more accurately identify people with a lower probability of error. Some of these methods use facial and fingerprint biometrics, which can become ineffective for a variety of reasons, including age and injury. As a result, choosing biometrics that are less prone to injury is an important factor. Therefore, this paper presents an identification system based on three biometrics: iris, fingerprint and face. In this method, the above biometrics are combined in two levels of feature and score, and simple and pre-trained convolutional networks are used to extract the feature from them. The results of this model on a virtual database consisting of three databases CASIA-IRIS, YaleB and FVC2000 show that the combination at the feature level gives better results due to the use of deep features. The results also indicate that the use of pre-trained network to extract features from facial biometrics, has made these biometrics more effective than the other two biometrics in accurately identifying the model.
Development of Simple Sequence Repeat markers (SSR) in Annona deceptrix Westra H. Rainner (Annonaceae) endangered species in Ecuador
Authors: Mendoza José Pico , Madrid Luis , Limongi Ricardo , Peña Geover , Flor Juan , Vélez Adrián , Quiroz Karla , Arevalo Bárbara , Carrasco Basilio 
Published: November 2022

Abstract
Annona deceptrix (Annonaceae) is a wild endemic endangered species. This species presents relevant attributes that man can use and be considered as a consumption option, but, its natural populations have a high degree of vulnerability, due to the loss their ecosystems caused by man. This study aimed to isolate and characterize SSR loci to determine the genetic diversity in A. deceptrix and other Annonaceae. We identified simple sequence repeat (SSR) regions in a microsatellite library from A. deceptrix. 22 polymorphic Simple Sequence Repeat (SSR) loci were isolated using new-generation kit Nextera of miseq illumine technology. The mean number of alleles per locus ranged from 2 to 8. Observed and expected heterozygosity ranged from 0.00 to 1.0 and 0.00 to 0.93, respectively. These are the first microsatellite markers developed for A. deceptrix. All SSR markers developed are promising candidates for analyzing genetic diversity within or between natural populations, also of analyzing pool genic in other species of Annona genus.
Large Eddy Simulation Study of Atmospheric Boundary Layer Flow over an Abrupt Rough-To-Smooth Surface Roughness Transition
Authors: Mondal Kingshuk , Naik K. Naveen , Abhinay K , Ghaisas Niranjan S 
Published: November 2022

Abstract
The atmospheric boundary layer flow downstream of an abrupt rough-to-smooth surface roughness transition is studied using large eddy simulations (LES) for a range of surface roughness ratios. Standard wall models assume horizontal homogeneity and are inapplicable for heterogeneous surfaces. Two heterogeneous-surface wall models are evaluated, one based on a local application of similarity theory using a twice-filtered velocity field (BZ model) and another based on a local friction-velocity obtained by blending the upstream and downstream profiles (APA model). The wall shear stress and the turbulence intensity (TI) are sensitive to the wall model while the mean streamwise velocity and the total shear stress (TSS) are less sensitive. The APA model is more accurate than the BZ model on comparison to previous experiments. The APA model results are sensitive to the ratio of the equilibrium and the internal boundary layer (IBL) heights. A value of 0.027 gives good agreement with experiments over a wide range of roughness ratios. The IBL height is insensitive to the turbulent quantity (TSS or TI) on which it is based. Several analytical relations for the IBL height are evaluated using the LES data. Two models are found to be accurate for different roughness ratios while one model is reasonable over the full range investigated. A phenomenological model is developed for the TI downstream of the roughness jump using a weighted average of the upstream and far-downstream profiles. The model yields reasonable predictions for all roughness ratios investigated.
Geochemical implication of hydrocarbon exploitation on soil around crude oil producing area of Uzere, Niger Delta region, Nigeria
Authors: Ibitoye Abel , Imasuen Isaac , OSISANYA WASIU OLAJUWON 
Published: November 2022

Abstract
The crude oil sector in Nigeria continues to be a significant source of income and foreign currency. However, operations related to oil exploration and production have the potential to seriously alter the environment, having an impact on ecosystems, water bodies, and human life. In many cases, pollution indices are viewed as a useful instrument for thoroughly evaluating contamination levels. Additionally, they may have a significant weight when evaluating soil quality and the forecast of long-term ecosystem viability, in the case of farmlands, in particular. Atomic absorption spectrometry was used to examine the heavy metal contents (AAS). Potential ecological risk index, Geoaccumulation index, Nemerow pollution, Pollution load index, Contamination Index (CI), and metal pollution index were the seven indicators employed in the study. The concentration of heavy metal such as Manganese (Mn), Iron (Fe), Copper (Cu), Zinc (Zn), Nickel (Ni), Lead (Pb), Chromium (Cr), Arsenic (As). Ranges from 11.9 to 184.1, 920 to 8870, 1.1 to 9.9, 9.7 to 60.4, 0.001 to 0.001, 2.4 to 34.7, 2.2 to 11.5 and 0.001 to 0.001 mg/kg respectively. The correlation matrix showed that there were positive correlation between Mn and Ni; Fe and Cu, Zn, Pb, Cr; Cu and Cr; Zn and Pb, Cr; and Pb and Cr; while a negative correlation exist between Cu and Ar, Cr and Ar.PCA showed that 75% of the samples in PC1 has loadings, in PC2, they have 50% of the parameters having loadings, in PC3 25% of the parameters had loading while in the PC4, 12.5% of the entire parameter has a loadings.Findings from aforementioned indices revealed that analyzed soil samples are polluted.
High prevalence of dyslipidaemia among persons with diabetes mellitus and hypertension at a tertiary hospital in Blantyre, Malawi
Authors: Katundu Kondwani G.H. , Mukhula Victoria , Phiri Tamara , Phiri Chimota , Filisa-Kaphamtengo Florence , Chipewa Pascal , Chirambo George , Mipando Mwapatsa , Mwandumba Henry C. , Muula Adamson S. , Kumwenda Johnstone 
Published: November 2022

Abstract
Background
Dyslipidaemia drives the process of atherosclerosis, and hence a significant modifiable risk factor complicating hypertension and diabetes. In Malawi, the prevalence, screening and management of dyslipidaemia among persons with diabetes mellitus have not been reported. This study aimed to investigate the prevalence, biochemical characteristics, screening and management practices for dyslipidaemia among persons with diabetes mellitus, hypertension, and diabetes mellitus and hypertension comorbidity at Queen Elizabeth Central hospital in Blantyre, Malawi.
Methods
This was a cross-sectional study conducted in 2021. A total of 256 adult participants (diabetes mellitus = 100); hypertension = 100; both conditions = 56) were included. Medical data and anthropometric measurements were recorded. Blood samples were analysed for HbA1C and serum lipids. Associated risk factors for dyslipidaemia were also assessed.
Results
Dyslipidaemia was prevalent in 58%, 55%, and 70% of participants with diabetes mellitus, hypertension, and both conditions. Low-density lipoprotein cholesterol (LDL-C) dyslipidaemia was the most common in all participant groups. Participants with both diabetes and hypertension had 2.4 times (95% CI 1.2–4.6) increased risk of LDL-C dyslipidaemia than those with diabetes alone (p < 0.02). Being overweight or obese and age over 30 years were risk factors for dyslipidaemia in patients with diabetes mellitus alone (OR 1.3 (95% CI 1.1–1.6), p < 0.04, and OR 2.2 (95% CI 1.2–4.7) (p < 0.01), respectively. Overweight and obesity predicted LDL-C dyslipidaemia in hypertensive patients (OR 3.5 (95% CI 1.2–9.9) p < 0.001). Poorly controlled hypertension was associated with a 1.8 times risk (95% CI 1.1–2.7) of dyslipidaemia in patients with both diabetes mellitus and hypertension (p < 0.01). Less than 1% of the participants had a lipogram performed before the study and on lipid-lowering therapy.
Conclusions
Dyslipidaemia with LDL-C derangement was highly prevalent, especially in individuals with both diabetes mellitus and hypertension, and there was absent use of lipid-lowering therapy. Screening and managing dyslipidaemia should be reinforced to reduce the risk of cardiovascular complications in this population at increased risk.
Post-operative Patellar Tilt Affects Knee Society Score After Total Knee Arthroplasty at 2 Years Follow up
Authors: Singh Swapnil , Mingzhou Toh , Zhao Zhiqing , Wang Jichuan , Krishna Lingaraj 
Published: November 2022

Abstract
Introduction

The effect of post-operative patella tracking on functional outcomes after total knee arthroplasty (TKA) remains unclear. Our study aimed to analyze the relationship of post-operative patellar tilt with functional outcome scores at 2 years after total knee arthroplasty.

Methods

Patient's data were retrieved from our institutions prospectively maintained TKA registry. 303 patients who underwent unilateral TKA from Jan 2012 to March 2017 were included in the study. After excluding patients with incomplete data and lost to follow up data for 231 patients were analyzed. Information was collected from pre-operative as well as post-operative skyline views and three functional outcome scores including SF-36, KSS, and WOMAC at pre-op, post-op 1 year, and post-op 2 years. Patella tilt (PT), patella displacement was calculated from radiology software in PACS. Patients were divided according to PT into 3 subgroups (PT < = 5 degrees, 5.1–10, > 10 degrees). Statistical analysis was done to identify the relationship of patella tilt and 3 functional.

Results

There was a significant improvement in post-operative patella tilt as compared to pre-operative patella tilt (3.35+-3.91vs5.65+-4.41, p-value = 0.0000). There was no significant difference in patella displacement in the postoperative period as compared to the pre-operative period. KSS functional score was significantly poor at 1 year and KSS objective score at 2 years in patients with PT more than 10 degrees. SF-36 and WOMAC were not significantly different in three subgroups based on PT.

Conclusion

Poor functional after TKA can be associated with an increase in patella tilt at 2 years follow up.
Level of evidence: II
Draft Genome Sequence of a Preterm Infant-derived isolate of Candida parapsilosis obtained using combined short and long read sequencing.
Authors: James Steve A , Telatin Andrea , Baker David , Evans Rhiannon , Phillips Sarah , Clarke Paul , Hall Lindsay , Carding Simon R 
Published: November 2022

Abstract
Candida parapsilosis is a human fungal pathogen of increasing incidence and a common cause of invasive candidiasis, notably in neonates born either prematurely or with low birthweight. Here, using a combination of short- and long-read sequencing, we provide the draft genome of C. parapsilosis NCYC 4289, a faecal-derived isolate from a young male infant born prematurely in the UK.
Novel ectophytic nematode antagonistic fungi and its potential application for nematode biocontrol
Authors: Mo Yi Xue , Kan Yuan Zi , Jia Lu Ming , Cao Xiao Tian , Sikandar Aatika , Wu Hai Yan 
Published: November 2022

Abstract
Dynamic of plant-parasitic nematodes population in soil is closely related to soil microorganisms. Fungi from Heterodera zeae cysts were isolated to explore the natural decline phenomenon of H. zeae population. A polyphasic method was used to identify the nematode-destroying fungal, including phylogenetic analysis of partial ITS, BenA, CaM, and RPB2 gene sequences, as well as macro- and micro-morphological analyses. The nematicidal activity of strain GX1 against H. zeae was assessed in vitro and greenhouse. Our findings revealed that strain GX1 is a novel species of Talaromyces, which named Talaromyces cystophila. It had strong parasitic and lethal effect on the H. zeae cysts with 91.11% parasitism on cysts at 3 d after treatment, and second-stage juveniles (J2s) and eggs inside the cysts appeared dense vacuoles and loss of vitality. The spore suspension and fermentation filtrate of T. cystophila inhibited significantly the hatching of H. zeae eggs and showed potential nematicidal activities on J2s. The hatching inhibition rates of eggs exposed to 1 × 108 cfu/ml spore suspensions or 20% 1-week fermentation filtrate (1-WF) for 15 days were 98.56% and 100%, respectively. The mortality of J2s exposed to 1 × 108 cfu/ml spore suspension reached 100% at 24 h, exposure to 50% 2-WF was 98.65% and 100% at 24 h and 48 h, respectively. Greenhouse experiments revealed that the spore suspension and fermentation broth considerably decreased H. zeae reproduction by 56.17%-78.76%. T. Cystophila is a potential biocontrol strain with parasitic and nematicidal activity, which deserves attention and application.
Evaluation of quality control and initial imaging properties of labeled [68Ga]GaPSMA-11 by elution of Monrol [68Ge]/[68Ga] generator
Authors: Yüksel Doğangün , Uğur Ayşe , Yaylalı Olga , Şengöz Tarık , Gültekin Aziz , Arslan Duygu 
Published: November 2022

Abstract
Background: The [68Ga]Cl3 precursor is not commercially available as a raw material or as a [68Ga]-labeled radiopharmaceutical. [68Ge]/[68Ga] generators are household type generators used to obtain [68Ga] radionuclide.
In this study, the product quality control parameters of [68Ga]GaPSMA-11 radiotracer labeled with [68Ga]Cl3 obtained from a GMP certified [68Ge]/[68Ga] generator manufactured by “Eczacıbaşı Monrol Nuclear Products Co.” (Turkey) were investigated.
We evaluated and reported the quality control data and the first clinical patient studies with this radiotracer. Biodistribution of [68Ga]-radiotracer by PET-CT was evaluated retrospectively. Twenty one patients with prostate cancer who agreed to participate in the study were included and underwent [68Ga]GaPSMA-11 injection and PET-CT imaging.
Results: The initial elution yield of the generator was determinde as 75% with reproducible stability. The amount of [68Ga] in the eluate by the HCl elution fraction was found to be appropriate. Of the 21 patients referred to our department, 10 patients were included in the study for staging and 11 patients for evaluation of response to treatment. The [68Ga]GaPSMA-11 uptake was observed in primary tumor and metastasis foci in 11 patients with metastatic prostate cancer. Heterogeneous [68Ga]GaPSMA-11 uptake was observed in prostate cancer and metastasis areas.
Conclusion: [68Ga]GaPSMA-11 radiopharmaceutical was synthesized from a new generator with good quality and satisfying PET-CT images were obtained.