bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potentially inappropriate medication use, polypharmacy, and falls among hospitalized patients
Authors: Li Shan‐Jen , Hwang Hei‐Fen , Yu Wen‐Yu , Lin Mau‐Roung 
Published: September 2022

AimThis matched case–control study investigated potentially inappropriate medication (PIM) use, polypharmacy, and other potential risk factors for falls among hospitalized older adults in Taiwan.MethodsDuring an 18‐month study period, 131 case patients who experienced a fall during hospitalization in an acute‐care hospital were identified and matched by the time of day, hospital ward, and age to controls (five for each case) who were selected through random systematic sampling. Data on demographics, medical characteristics, and all orally and intravascularly administered medications during hospitalization prior to a fall were collected. PIMs were assessed using the 2019 Beers criteria.ResultsA conditional logistic regression analysis revealed that admission to the departments of internal medicine (odds ratio [OR] = 2.33; 95% confidence interval [CI] = 1.09–4.91) and neurology and rehabilitation (OR = 4.67; 95% CI = 2.08–10.5), diabetes with end‐organ damage (OR = 2.07; 95% CI = 1.11–3.86), PIM use of central nervous system drugs (OR = 1.81; 95% CI = 1.15–2.86), use of colchicine (OR = 5.49; 95% CI = 1.34–22.5) and spironolactone (OR = 4.54; 95% CI = 1.31–15.8) for renal function impairment, and polypharmacy (≥5 medications; OR = 1.81; 95% CI = 1.05–3.10) significantly increased the risk of falls. By contrast, being overweight or obese (OR = 0.47; 95% CI = 0.29–0.78) was associated with a significantly lower risk of falls.ConclusionsPIM use may increase the risk of falls in hospitalized older patients, and PIM identification and evaluation can reduce this risk. Geriatr Gerontol Int 2022; 22: 857–864.
Fermentation quality, nutritive value and in vitro ruminal digestion of Napier grass, sugarcane top and their mixed silages prepared using lactic acid bacteria and formic acid
Authors: Xie Huade , Xie Fang , Guo Yanxia , Liang Xin , Peng Lijuan , Li Mengwei , Tang Zhenhua , Peng Kaiping , Yang Chengjian 
Published: September 2022

AbstractThis study aimed to determine the fermentation quality, nutritive value and in vitro ruminal digestion of silages produced with mixtures of Napier grass (NG) and sugarcane top (ST) in five different ratios of fresh matter: 100:0 (N100), 75:25 (N75), 50:50 (N50), 25:75 (N25) and 0:100 (N0) with or without lactic acid bacteria (LAB) and formic acid (FA). The NG contained a higher crude protein (CP) content and buffering capacity, but lower dry matter (DM), organic matter, neutral detergent fiber, acid detergent fiber and water‐soluble carbohydrates contents than ST. The N25 silage fermented well, with a significantly higher lactic acid (LA) content (p < .05) and lower pH and NH3‐N concentration than those of other mixed silages (p < .05). The FA addition resulted in the highest CP content and lowest pH, LA, acetic acid (AA) and NH3‐N contents, while LAB addition resulted in the highest LA content compared with other treatments. Although in vitro DM digestibility (IVDMD) did not significantly differ among the mixed silages (p > .05), mixing with ST and adding LAB or FA increased the IVDMD. Gas production (GP) and AA content of N25 silages were significantly higher than those of other silages (p < .05). The LAB‐ or FA‐treated silages had higher IVDMD, GP, total volatile fatty acid and AA contents (p < .05) but lower pH compared with the control silage (p < .05). These results demonstrated that NG utilization improved upon mixing with ST due to the enhanced fermentation during ensiling, and the optimum mixing ratio for NG and ST was 25:75 on FM basis. Using LAB and FA as additives during ensiling can improve silage fermentation quality and in vitro ruminal digestion.
The relationship of headache as a symptom to COVID‐19 survival: A systematic review and meta‐analysis of survival of 43,169 inpatients with COVID‐19
Authors: Gallardo Víctor J. , Shapiro Robert E. , Caronna Edoardo , Pozo‐Rosich Patricia 
Published: September 2022

AbstractObjectiveTo study the relationship between coronavirus disease 2019 (COVID‐19) mortality and headache among patients evaluated for COVID‐19 in Emergency Departments and hospitals.BackgroundCOVID‐19 has disparate impacts on those who contract it. Headache, a COVID‐19 symptom, has been associated with positive disease prognosis. We sought to determine whether headache is associated with relative risk of COVID‐19 survival.MethodsA systematic search in PubMed was performed independently by three reviewers to identify all COVID‐19 clinical inpatient series in accordance with the PRISMA guideline. Studies were included if the study design, COVID‐19 confirmation method, disease survival ratio, and presence of headache symptom were accessible. We included 48 cohort studies with a total of 43,169 inpatients with COVID‐19: 81.4% survived (35,132/43,169) versus 18.6% non‐survived (8037/43,169). A meta‐analysis of the included studies was then performed. The study was registered on PROSPERO (ID: CRD42021260151).ResultsWhen considering headache as a symptom of COVID‐19, we observed a significantly higher survival rate (risk ratio: 1.90 [1.46, 2.47], p < 0.0001) among COVID‐19 inpatients with headache compared to those without headache.ConclusionHeadache among patients with COVID‐19 presenting to hospitals may be a marker of host processes which enhance COVID‐19 survival. Future studies should further confirm these findings, in order to better understand this relation and to try to address possible limitations related to the inclusion of more severe patients who would be unable to report symptoms (e.g., patients who were intubated).
Experiences of patients with cancer and their relatives confronted with COVID‐19 related delay or change in care: A qualitative study
Authors: Kenis Ilyse , Theys Sofie , Daem Michiel , Decoene Elsie , Demolder Veerle , Duprez Veerle , Pape Eva , Quaghebeur Marijke , Verhaeghe Sofie , Foulon Veerle , Van Hecke Ann 
Published: September 2022

AbstractAimsTo provide in‐depth insight into how patients and their relatives experienced change or delay in cancer treatment and care due to COVID‐19.DesignA qualitative study including semi‐structured interviews with patients with cancer and their relatives.MethodsBetween July and October 2020, 42 patients who were confronted with a change or delay in cancer treatment or care, and 11 relatives were interviewed. Data collection and analysis were performed according to the most important methods of grounded theory, including iterative data collection and analysis, theoretical sampling, constant comparative analysis and theoretical sensitivity.ResultsThis study shows that patients with cancer and relatives experienced paradoxical feelings when confronted with change or delay in treatment or care due to COVID‐19. Patients and relatives felt relieved (e.g. less risk of infection), but were also concerned and anxious (e.g. fear for progression, fear for more side effects). Due to these ambivalent feelings, it was difficult for patients and relatives to cope with the change or delay in treatment or care, both when this was decided by the physician and by themselves. In combination with the general impact of COVID‐19 on their daily lives, the change or delay led to additional distress. The interviews showed that exploring the meaning of change or delay of care for patients and their relatives and discussing what would help them might prevent or relieve distress.ConclusionThe findings of our study show that COVID‐19 and the associated delay or changes in cancer treatment and care had a major impact on the well‐being of patients and their relatives. Person‐oriented care is even more important during (emergency) situations in which care might be changed or delayed.
Philosophy and the clinic: Stigma, respect and shame
Authors: Loughlin Michael , Dolezal Luna , Hutchinson Phil , Subramani Supriya , Milani Raffaella , Lafarge Caroline 
Published: September 2022

AbstractSince its foundation in 2010, the annual philosophy thematic edition of this journal has been a forum for authors from a wide range of disciplines and backgrounds, enabling contributors to raise questions of an urgent and fundamental nature regarding the most pressing problems facing the delivery and organization of healthcare. Authors have successfully exposed and challenged underlying assumptions that framed professional and policy discourse in diverse areas, generating productive and insightful dialogue regarding the relationship between evidence, value, clinical research and practice. These lively debates continue in this thematic edition, which includes a special section on stigma, shame and respect in healthcare. Authors address the problems with identifying and overcoming stigma in the clinic, interactional, structural and phenomenological accounts of stigma and the ‘stigma‐shame nexus’. Papers examine the lived experience of discreditation, discrimination and degradation in a range of contexts, from the labour room to mental healthcare and the treatment of ‘deviancy’ and ‘looked‐after children’. Authors raise challenging questions about the development of our uses of language in the context of care, and the relationship between stigma, disrespect and important analyses of power asymmetry and epistemic injustice. The relationship between respect, autonomy and personhood is explored with reference to contributions from an important conference series, which includes analyses of shame in the context of medically unexplained illness, humour, humiliation and obstetric violence.
Alternative approach to treating dark circles: A case report
Authors: Grillo Ricardo , de Campos Francisco Ubiratan Ferreira , de Barros Tarley Eloi Pessoa , Jodas Claudio Roberto Pacheco 
Published: September 2022

AbstractObjectivesDark circles under the eyes are a common condition worldwide with multiple treatment options. The aim of this paper is to report a case of dark circles treated with ozone therapy, which showed a very reasonable clinical improvement.Case ReportA case of dark circles under the eyes treatment with ozone therapy concentrations and doses was reported. We searched MEDLINE treatment options for dark circles. Literature on this subject is scarce. CARE guidelines have been adopted for this case report.ResultsOzone therapy is a really effective biostimulator, that reduces spots and wrinkles. In this case, the patient and healthcare professionals were satisfied with just two ozone therapy sessions. This is an interesting alternative treatment for this common condition.ConclusionsOzone therapy is a safe, inexpensive, and quick treatment for dark circles under the eyes. It can be used alone or in combination with other methods.
Clinical evaluation of the brightening effect of chitosan‐based cationic liposomes
Authors: Lee Mi So , Kim Su Ji , Lee Jun Bae , Yoo Hyuk Sang 
Published: September 2022

AbstractBackgroundCationic liposomes can enhance the permeability of drugs in 3‐D skin. Chitosan is considered a safe material for percutaneous delivery; thus, this study uses chitosan‐incorporated cationic liposomes.AimsThis study investigated the improvement in skin brightness, melanin, and melasma after treatment niacinamide‐incorporated chitosan cationic liposomes.MethodsA skin brightening agent, niacinamide, was formulated into cationic liposomes to facilitate percutaneous absorption and was clinically tested in 21 Korean female subjects. Cationic liposomes were prepared using a high‐pressure homogenizer after mixing an oil phase containing lecithin and cholesterol and an aqueous phase containing niacinamide and chitosan.ResultsThe cationic liposomes exhibited stability over 28 days, with a particle size of 255–275 nm and zeta potential of 10–14 mV. Cationic liposomes containing niacinamide and a control formulation were applied to the left and right side of the face, respectively, twice daily for 28 days. Skin brightness, melanin index, and area of melasma were significantly enhanced where cationic liposomes were used, in comparison with formulations without cationic liposomes, demonstrating a 1.38–2.08‐fold improvement.ConclusionThus, we established that chitosan liposomes augmented the percutaneous absorption of niacinamide and improved the appearance of the skin.
Can Corporate Social Responsibility Lead to Social License? A Sentiment and Emotion Analysis
Authors: Ho Shuna Shu Ham , Oh Chang Hoon , Shapiro Daniel 
Published: September 2022

AbstractThe termsocial license(SL) refers to the acceptance or approval by a community of a company's presence. It is generally assumed in the literature that effective corporate social responsibility (CSR) actions will lead to an SL. In this study we examine the CSR‐SL relationship at the local community level and establish boundary conditions on the effectiveness of local CSR in creating an SL. Using consent‐based micro‐social contract theory, we theorize that commitment to local CSR improves the level to which a local community grants an SL to a multinational corporation (MNC), but the impact is moderated by the global legitimacy of the parent company, the nature of institutions in the host country, and the degree of polarization within the focal community. Based on 3696 articles regarding 43 global mining MNCs operating in 523 local communities between 2008 and 2020, we use natural language processing and sentiment analysis to evaluate the degree to which a local community grants an SL. Our empirical evidence indicates that local CSR does positively influence the granting of an SL, but the effect is reduced when there is strong rule of law or high community polarization and increased when the focal firm has strong global legitimacy.
Overexpression of DEC1 in the epithelium of OSF promotes mesenchymal transition via activating FAK/Akt signal axis
Authors: Hu Xin , Wang Weiming , Hu Yue , Chen Wenxin , Wang Can , Yang Liudi , Mao Ting , Xia Kun , Min Anjie , Xiong Haofeng , Su Tong 
Published: September 2022

AbstractBackgroundPrevious studies on oral submucous fibrosis (OSF) mostly focused on the activation of fibroblasts and collagen metabolism, while little involved in the epithelium. As we have reported the role of differentiated embryo‐chondrocyte expressed gene 1 (DEC1) in oral cancer and other precancerous lesions, this research aimed to explore its role in the OSF epithelium.MethodsExpression of DEC1 and other proteins were investigated in tissue array constructed with 33 OSF and 14 normal oral mucosa (NOM) tissues. Human oral keratinocytes treated with arecoline and/or hypoxia were used to simulate OSF epithelium and detected for morphological and protein alterations. Inhibition of DEC1 was used to explore its mediating role. Finally, animal models of OSF constructed by locally arecoline injecting in buccal mucosa were used to verify our findings.ResultsDEC1 overexpression could be detected in the epithelium of OSF compared with that in NOM followed by phosphorylated FAK and Akt, and DEC1 showed a significant positive correlation with them. Cytology experiment revealed that OSF‐like treatment could upregulate DEC1 expression followed by phosphorylated FAK, Akt, but inhibit E‐cadherin, while knockdown of DEC1 could suppress the effects. In addition, OSF mice revealed higher expression of DEC1 in the epithelium of buccal mucosa, along with synchronized alterations of phosphorylated FAK and Akt.ConclusionIn the epithelium of OSF, overexpression of DEC1 induced activation of FAK/Akt signal axis, caused mesenchymal transition in epithelial cells, and may promote malignant transformation of OSF. Targeting DEC1 in OSF could be promising a new target for the diagnosis and treatment of this process.
Principles for the selection of a sensory panel for the evaluation of car interior materials
Authors: Fuchs Andreas , Engleder Stefanie , Huber Jürgen , Leitner Erich 
Published: September 2022

AbstractVehicle interior air quality has gained importance since the 1990s. One of the most widely accepted methods to measure emissions in this respect is the VDA 270—Determination of the odor characteristics of trim materials in motor vehicles. So far, it describes the odor evaluation procedure, but not the selection of the sensory panel. Therefore, the aim of this study was to investigate principles that might be applicable for the selection of a VDA 270 panel. Based on this work, a dedicated three‐step approach is detailed to aid in selecting a panel. It comprises of an odor threshold determination, a hedonic tone evaluation and a reproducibility test. In addition, a “Screening 12” test was performed to verify the assessors' olfactory function. The selection was not specific to gender and the age of the candidates ranged from 19 to 55 years. Out of 26 volunteers, only 10 were able to meet all of the self‐developed criteria for the panel. With this approach, the individual ratings of the selected panelists did not deviate by more than two odor grades for the selected polyolefin samples considering the VDA 270 scale.Practical ApplicationsA meaningful comparison and interpretation of VDA 270 data requires objective test results. This is challenging as the VDA 270 scale is, at least partly, subjective and only a small minimum number of panelists is defined. The terminology used in the 6‐point scale itself was investigated in order to deduce potential tests for the panel selection procedure. Relevant international standards that are linked to the topic of interior air quality were screened to compare related guidelines for the panel selection. The implementation of a selection procedure needs to consider practical aspects in an industrial environment, too. Therefore, feasibility and quality issues are discussed to overcome some of those problems. As fundamental questions of sensory testing are involved this work might be relevant for other olfactory screening applications in an industrial setup. However, where hedonic tone measurements are required only consumer panels can provide reliable information.
The rice OsERF101 transcription factor regulates the NLR Xa1‐mediated immunity induced by perception of TAL effectors
Authors: Yoshihisa Ayaka , Yoshimura Satomi , Shimizu Motoki , Sato Sayaka , Matsuno Shogo , Mine Akira , Yamaguchi Koji , Kawasaki Tsutomu 
Published: September 2022

Summary

Plant nucleotide‐binding leucine‐rich repeat receptors (NLRs) initiate immune responses by recognizing pathogen effectors. The rice gene Xa1 encodes an NLR with an N‐terminal BED domain, and recognizes transcription activator‐like (TAL) effectors of Xanthomonas oryzae pv oryzae (Xoo). Our goal here was to elucidate the molecular mechanisms controlling the induction of immunity by Xa1.

We used yeast two‐hybrid assays to screen for host factors that interact with Xa1 and identified the AP2/ERF‐type transcription factor OsERF101/OsRAP2.6. Molecular complementation assays were used to confirm the interactions among Xa1, OsERF101 and two TAL effectors. We created OsERF101‐overexpressing and knockout mutant lines in rice and identified genes differentially regulated in these lines, many of which are predicted to be involved in the regulation of response to stimulus.

Xa1 interacts in the nucleus with the TAL effectors and OsERF101 via the BED domain. Unexpectedly, both the overexpression and the knockout lines of OsERF101 displayed Xa1‐dependent, enhanced resistance to an incompatible Xoo strain. Different sets of genes were up‐ or downregulated in the overexpression and knockout lines.

Our results indicate that OsERF101 regulates the recognition of TAL effectors by Xa1, and functions as a positive regulator of Xa1‐mediated immunity. Furthermore, an additional Xa1‐mediated immune pathway is negatively regulated by OsERF101.
Chronic non‐bacterial osteomyelitis in children: Outcomes, quality of life
Authors: Ekici Tekin Zahide , Gülleroğlu Nadide Başak , Çelikel Elif , Aydın Fatma , Kurt Tuba , Tekgöz Nilüfer , Sezer Müge , Karagöl Cüneyt , Coşkun Serkan , Kaplan Melike Mehveş , Ekşioğlu Ayşe Secil , Acar Banu Çelikel 
Published: September 2022

AbstractBackgroundChronic non‐bacterial osteomyelitis is a chronic sterile inflammatory bone condition. We aimed to describe patients' clinical and radiographic findings and to evaluate their response to therapy and their quality of life.MethodsThis cross‐sectional study included 18 patients from a single center in Turkey whose clinical, radiological features, and outcomes were reviewed retrospectively. The quality of the patients' lives after treatment was compared with healthy controls using the Pediatric Quality of Life Inventory 4.0.ResultsThe median age of disease onset was 12 years (IQR 10–14 years) and 11 (61.1%) patients were male. The median follow‐up duration was 15 months (IQR 12–22 months). The persistent form of chronic non‐bacterial osteomyelitis was the most common pattern in 15 (83.3%) patients and a recurrent pattern was defined in three (16.7%) patients. The lesions were multifocal in all patients and 15 (83.3%) patients had symmetric distribution in whole‐body magnetic resonance imaging. The most common sites of arthritis were the knee and sacroiliac joints. Methotrexate was used in 16 (88.9%) patients as first‐line therapy. However, some patients were unresponsive to the first‐line therapy and needed tumor necrosis factor‐α inhibitors (55.6%) and bisphosphonates (16.7%). We observed remission in only four (22.2%) patients, and three (16.7%) patients were unresponsive. The patients had a significantly poorer quality of life than controls (P = 0.005).ConclusionsChronic non‐bacterial osteomyelitis is an insidious disease that requires detailed analysis for diagnosis and whole‐body magnetic resonance imaging is an effective tool for its diagnosis. Despite the advanced treatment, patients with chronic non‐bacterial osteomyelitis have a poor quality of life.
On the drivers of potential customers' interest in long‐term care insurance: Evidence from Switzerland
Authors: Fuino Michel , Ugarte Montero Andrey , Wagner Joël 
Published: September 2022

AbstractAs the risks associated with aging start to materialize, societies become more aware of the financial consequences of long‐term care (LTC). While limited coverage is available through social insurance in many countries, attractive offers of private products barely exist and a lack of knowledge about LTC insurance persists. Based on a novel survey on aging, health, and dependence conducted in Switzerland, this study aims to comprehend the key drivers that make individuals interested in buying care insurance products for themselves. Using models that combine features from both classical statistics and machine learning techniques, we depict the characteristics of potential buyers based on key economic, social, demographic, and political factors. We find that factors relating to the awareness and understanding of LTC are extremely relevant. Self‐perceived health, behavior, and trust relationships between customers and insurers are important. Socioeconomic factors only play a secondary role in the decision‐making process. Our findings are relevant beyond the academic community and for policymakers and private insurers alike.
THE SYNTAX OF TWO TYPES OF GAPPING IN SPANISH*
Authors: Jung Wonsuk 
Published: September 2022

AbstractThis paper argues that gapping in Spanish is not a single phenomenon and can be derived from different source structures. The first type of gapping in Spanish involves clausal coordination and is thus derived through TP‐deletion, whereas the second type contains low coordination below TP, which allows it to be derived by either vP‐deletion or Across‐The‐Board (ATB) verb movement whose availability depends on the subject‐verb agreement patterns found in gapping. This approach also extends to cases where the conjuncts in gapping display various non‐canonical word orders, which also fall under two types of gapping and can be analyzed using the same mechanisms as those applicable to SVO‐conjuncts.