bluuebunny/crossref_metadata_2025_split huggingface dataset:
A restoring force model for frames with steel tube columns filled with recycled aggregate concrete
Authors: Zhang Xianggang , Zhou Gaoqiang , Liu Xuyan , Chen Jiahao , Xu Ping 
Published: November 2022

AbstractTo establish a restoring force model for recycled aggregate concrete‐filled steel tube (RACFST) frames, the quasistatic tests on two frames comprising two RACFST columns and a reinforced recycled aggregate concrete (RRAC) beam each was carried out. The recycled coarse aggregate replacement ratio was 100%. The failure mechanism, hysteretic curves, and strain response of the specimens were discussed. By analyzing the degradation of the load bearing capacity with increasing displacement amplitude and combining the hysteretic curves and stiffness degradation relationships, a restoring force model of load versus displacement adopting a trilinear approximation was proposed. The characteristic points of the model were the relative yield point, relative peak point, and relative failure point. Results showed that bending‐shear or bending failure occurred at the ends of specimen beams and plastic hinges formed there earlier than at the column ends. The hysteretic curves of load versus displacement were essentially symmetric in a full shuttle shape. The proposed restoring force model adopting trilinear approximation agreed well with the experimental hysteretic curves under low‐cycle loading and can thus be recommended to perform the elastoplastic analysis of seismic response for this new type of composite structures.
Bone marrow mesenchymal stem cells repair hexavalent chromium‐induced testicular injury by regulating autophagy and ferroptosis mediated by the AKT/mTOR pathway in rats
Authors: Zhuge Ruijian , Li Zhongrun , He Changhao , Ma Wenxuan , Yan Jun , Xue Qian , Wang Rui , Liu Ying , Lu Rifeng , Du Haiying , Yin Fei , Guo Li 
Published: November 2022

AbstractThere is no ideal therapy for testicular damage induced by Cr(VI); however, bone marrow mesenchymal stem cells (BMSCs) transplantation may be a promising therapy. A Cr(VI) solution was administered to rats by intraperitoneal injection for 30 days, then BMSCs from donor rats were transplanted. Two weeks later, decreased activity and appetite, along with other pathological changes, were improved in the BMSCs group. The location of BMSCs in damaged testes was observed via laser confocal microscopy. Chromium content in the Cr(VI) and BMSCs groups significantly increased compared with that in the control group, but there was no significant difference between the two groups, as revealed by atomic absorption spectrometry. The ferrous iron and the total iron content of testes in the BMSCs group were significantly lower than those in the Cr(VI) group, as observed by Lillie staining and a tissue iron assay kit. Western blotting and immunohistochemical analyses revealed that the expression of Beclin 1, LC3B, 4‐hydroxynonenal, and transferrin receptor 1 was decreased in the BMSCs group, compared with the Cr(VI) group. The expression of glutathione peroxidase 4 (GPX4), SLC7A11, p‐AKT, mammalian target of rapamycin (mTOR), and p‐mTOR in the BMSCs group was higher than that in the Cr(VI) group. Taken together, we propose that BMSCs repair Cr(VI)‐damaged testes by alleviating ferroptosis and downregulating autophagy‐associated proteins through the upregulation of AKT and mTOR phosphorylation.
Integrated energy conversion units in nanoscale frameworks induce sustained generation and amplified lethality of singlet oxygen in oxidative therapy of tumor
Authors: Zhu Jing , Ding Tao , Jin Kaifei , Xing Yuxin , Huang Jixi , Xia Daqing , Cai Kaiyong , Zhang Jixi 
Published: November 2022

AbstractReactive oxygen species (ROS) driven endoplasmic reticulum (ER) stress is highly promising for tumor therapy but restrained by the nondurable introduction and limited lifetime of oxidative species. Here, a therapeutic nanosystem with sustainable ROS generation ability was developed by accommodating luminol derivatives (L012) in hyaluronic acid‐modified metal‐organic frameworks of Fe3+ and porphyrin ligand (TCPP). After particle accumulation in the tumor, ∙OH radicals from Fe3+ sites catalyzed conversion of H2O2 can react with confined L012 transducers to generate chemiluminescence (CL). Because of the distance constraints, the CL energy was significantly extracted (96%) by adjacent TCPP and further activate oxygen to long‐lifetime singlet oxygen (1O2), whose yield can be further boosted by the catalase‐like activity of the frameworks. By regulating the substrate consumption through energy conversion, the cascade process resulted in increased ROS levels (2.4‐fold) and sustainable oxidation (24 h), which induced continuously accumulated ER stress, high autophagic levels, and amplified lethality against the tumor. This work opens a new avenue to explore reticular nanostructures with complementarily arranged and synergistically spaced conversion units in advancing ROS therapy.
Growing Spicy ONIOMs: Extending and generalizing concepts of ONIOM and many body expansions
Authors: Seeber Phillip , Seidenath Sebastian , Steinmetzer Johannes , Gräfe Stefanie 
Published: November 2022

AbstractThe ONIOM method and many extensions to it provide capabilities to treat challenging multiscale problems in catalysis and material science. Our open‐source program Spicy is a flexible toolkit for ONIOM and fragment methods. Spicy includes a generalization of multicenter‐ONIOM, a higher‐order multipole embedding scheme, and fragment methods as useful extensions of our own n‐layered integrated molecular orbital and molecular mechanics (ONIOM), which allow applying ONIOM and high accuracy calculations to a wider range of systems. A calculation on the metallo‐protein hemoglobin demonstrates the versatility of the implementation.This article is categorized under:
Electronic Structure Theory > Combined QM/MM Methods
Molecular and Statistical Mechanics > Molecular Interactions
Quantum Computing > Theory Development
Understanding the immunological interactions of engineered nanomaterials: Role of the bio‐corona
Authors: Fadeel Bengt 
Published: November 2022

AbstractEngineered nanomaterials are a broad class of materials with the potential for breakthrough applications in many sectors of society not least in medicine. Consequently, safety assessment of nanomaterials and nano‐enabled products with respect to human health and the environment is of key importance. To this end, the biological interactions of nanoscale materials must be understood. Here, the dual “identities” of nanomaterials, namely, the material‐intrinsic properties or synthetic identity and the acquired, context‐dependent properties or biological identity, are discussed in relation to nanomaterial interactions with the immune system, our main defense against foreign intrusion. Specifically, we address whether macrophages and other innate immune cells respond to the synthetic identity or the biological identity of nanomaterials, that is, the surface adsorbed proteins and/or other biomolecules known as the bio‐corona, or both?This article is categorized under:
Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials
Nanoparticles for vaccine and gene therapy: Overcoming the barriers to nucleic acid delivery
Authors: Mollé Lara M. , Smyth Cameron H. , Yuen Daniel , Johnston Angus P. R. 
Published: November 2022

AbstractNucleic acid therapeutics can be used to control virtually every aspect of cell behavior and therefore have significant potential to treat genetic disorders, infectious diseases, and cancer. However, while clinically approved to treat a small number of diseases, the full potential of nucleic acid therapeutics is hampered by inefficient delivery. Nucleic acids are large, highly charged biomolecules that are sensitive to degradation and so the approaches to deliver these molecules differ significantly from traditional small molecule drugs. Current studies suggest less than 1% of the injected nucleic acid dose is delivered to the target cell in an active form. This inefficient delivery increases costs and limits their use to applications where a small amount of nucleic acid is sufficient. In this review, we focus on two of the major barriers to efficient nucleic acid delivery: (1) delivery to the target cell and (2) transport to the subcellular compartment where the nucleic acids are therapeutically active. We explore how nanoparticles can be modified with targeting ligands to increase accumulation in specific cells, and how the composition of the nanoparticle can be engineered to manipulate or disrupt cellular membranes and facilitate delivery to the optimal subcellular compartments. Finally, we highlight how with intelligent material design, nanoparticle delivery systems have been developed to deliver nucleic acids that silence aberrant genes, correct genetic mutations, and act as both therapeutic and prophylactic vaccines.This article is categorized under:
Nanotechnology Approaches to Biology > Cells at the Nanoscale
Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease
Biology‐Inspired Nanomaterials > Lipid‐Based Structures
Market entry system considering the biosafety of nanomedical devices in China
Authors: Wen Hairuo , Yang Ying , Geng Xingchao 
Published: November 2022

AbstractOur current knowledge on nanomaterials is mostly built on data from basic studies, and the application and developmental potentials of nanomaterials are emphasized. On the other hand, standard evaluation methods, models, exposure methods, standards, and guidelines for biological effect evaluation are inadequate. In response to the bottlenecks of supervision, scientific research institutes and regulatory organizations in China have cooperated closely to research and establish an evaluation system for nanomedical devices, and silver‐containing nanomaterials have been adopted as an example. In such a context, reference materials, characterization strategies, in vitro and in vivo distribution and toxicity evaluation standards have been established. This article highlights research on the risk assessment of nanomedical device products (taking silver‐containing nanomedical device products as an example) in China, including the characterization and release determination strategies, determination of nanosilver in tissues, applications of three‐dimensional skin models and in vitro and toxicity evaluation standards have been established. This article highlights research on technical standards. As a consequence, the “Guidelines for the safety and effectiveness evaluation of nanomedical devices” were published in 2021, and a market entry framework for nanomedical devices has been preliminarily formed as a significant component in scientific supervision. This Guideline supervises the review and supervision of nanomedical devices and, therefore, provides a guarantee for the market access of nanomedical devices in China.This article is categorized under:
Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials
Toxicology and Regulatory Issues in Nanomedicine > Regulatory and Policy Issues in Nanomedicine
Theorie und Forschungsstand
Authors: Gercke Marcus 
Published: November 2022

ZusammenfassungDie Einkommensungleichheitshypothese ist eine Theorie mittlerer Reichweite, welche ihren Ursprung in den Gesundheitswissenschaften besitzt. Ihrer Annahme nach sind Gesellschaften, in denen Einkommen und Wohlstand ungleicher verteilt sind, weniger gesund und stärker von sozialen Problemen betroffen. Ihr Gültigkeitsanspruch beschränkt sich dabei auf wohlhabende Gesellschaften und ist im wissenschaftlichen Diskurs seither umstritten.
Daten und Methoden
Authors: Gercke Marcus 
Published: November 2022

ZusammenfassungDie vorliegende Arbeit fokussiert auf soziale Probleme in wohlhabenden Ländern. Um entsprechende Länder zu identifizieren, wurde auf die Einkommensklassifikation der World Bank zurückgegriffen (Fantom & Serajuddin, 2016). Gemessen am Bruttonationaleinkommen pro Kopf werden Länder in vier Einkommensklassen unterteilt: (1) hohes Einkommen, (2) oberes mittleres Einkommen, (3) unteres mittleres Einkommen und (4) geringes Einkommen.
Ergebnisdiskussion
Authors: Gercke Marcus 
Published: November 2022

ZusammenfassungDie vorliegende Studie über soziale Probleme in 40 reichen Ländern im Zeitraum von 1990–2020 stellt derzeit die aktuellste und umfassendste Überprüfung von Wilkinson und Picketts Erweiterung der Einkommensungleichheitshypothese für soziale Probleme dar. In Bezug auf den langen wissenschaftlichen Streit um den Einfluss von Einkommensungleichheit auf das Ausmaß sozialer Probleme liefert die vorliegende Arbeit aufgrund ihrer Systematik wichtige Forschungsergebnisse. Es können drei wesentliche Erkenntnisse hervorgehoben werden: (1) Einkommensungleichheit allein stellt sich als eher ungenügender Prädiktor für soziale Probleme heraus. (2) Vor allem Wohlstand, aber auch ethnische Fraktionalisierung und Vertrauen, hängen signifikant und sogar unabhängig von Einkommensungleichheit mit dem Ausmaß sozialer Probleme zusammen. (3) Die geschätzten Zusammenhänge zwischen den Einflussfaktoren und Problemen sind deutlich heterogener als erwartet, was gegen Wilkinson und Picketts Hypothese eines einzelnen zentralen Mechanismus spricht, das Ausmaß sozialer Probleme auf der Makroebene zu erklären. Im Nachfolgenden werden die Forschungsergebnisse entlang der fünf aufgestellten Forschungshypothesen diskutiert.
Fazit
Authors: Gercke Marcus 
Published: November 2022

ZusammenfassungDas Ziel der vorliegenden Masterarbeit war es, den Einfluss von Einkommensungleichheit, Wohlstand, ethnischer Fraktionalisierung, Vertrauen und des gesellschaftlichen Wertewandels auf das Ausmaß sozialer Probleme (Gewalt, Inhaftierungen, Teenagerschwangerschaften, niedrige schulische Leistungen, niedrige Wahlbeteiligung) zu überprüfen. Ausgangspunkt der Arbeit ist die kontroverse Debatte um Wilkinson und Picketts Spirit Level Theory (2016 [2010]). Sie führt die Betroffenheit wohlhabender Länder von gesundheitlichen und sozialen Problemen auf die Höhe der Einkommensungleichheit zurück.
Interior Hölder continuity for singular-degenerate porous medium type equations with an application to a biofilm model
Authors: Hissink Muller Victor 
Published: November 2022

AbstractWe show interior Hölder continuity for a class of quasi-linear degenerate reaction-diffusion equations. The diffusion coefficient in the equation has a porous medium type degeneracy and its primitive has a singularity. The reaction term is locally bounded except in zero. The class of equations we analyze is motivated by a model that describes the growth of biofilms. Our method is based on the original proof of interior Hölder continuity for the porous medium equation. We do not restrict ourselves to solutions that are limits in the weak topology of a sequence of approximate continuous solutions of regularized problems, which is a common assumption.
Glioblastoma PET/MRI: kinetic investigation of [18F]rhPSMA-7.3, [18F]FET and [18F]fluciclovine in an orthotopic mouse model of cancer
Authors: Lindemann Marcel , Oteiza Ana , Martin-Armas Montserrat , Guttormsen Yngve , Moldes-Anaya Angel , Berzaghi Rodrigo , Bogsrud Trond Velde , Bach-Gansmo Tore , Sundset Rune , Kranz Mathias 
Published: November 2022

Abstract
Purpose
Glioblastoma multiforme (GBM) is the most common glioma and standard therapies can only slightly prolong the survival. Neo-vascularization is a potential target to image tumor microenvironment, as it defines its brain invasion. We investigate [18F]rhPSMA-7.3 with PET/MRI for quantitative imaging of neo-vascularization in GBM bearing mice and human tumor tissue and compare it to [18F]FET and [18F]fluciclovine using PET pharmacokinetic modeling (PKM).

Methods
[18F]rhPSMA-7.3, [18F]FET, and [18F]fluciclovine were i.v. injected with 10.5 ± 3.1 MBq, 8.0 ± 2.2 MBq, 11.5 ± 1.9 MBq (n = 28, GL261-luc2) and up to 90 min PET/MR imaged 21/28 days after surgery. Regions of interest were delineated on T2-weighted MRI for (i) tumor, (ii) brain, and (iii) the inferior vena cava. Time-activity curves were expressed as SUV mean, SUVR and PKM performed using 1-/2-tissue-compartment models (1TCM, 2TCM), Patlak and Logan analysis (LA). Immunofluorescent staining (IFS), western blotting, and autoradiography of tumor tissue were performed for result validation.

Results
[18F]rhPSMA-7.3 showed a tumor uptake with a tumor-to-background-ratio (TBR) = 2.1–2.5, in 15–60 min. PKM (2TCM) confirmed higher K1 (0.34/0.08, p = 0.0012) and volume of distribution VT (0.24/0.1, p = 0.0017) in the tumor region compared to the brain. Linearity in LA and similar k3 = 0.6 and k4 = 0.47 (2TCM, tumor, p = ns) indicated reversible binding. K1, an indicator for vascularization, increased (0.1/0.34, 21 to 28 days, p < 0.005). IFS confirmed co-expression of PSMA and tumor vascularization. [18F]fluciclovine showed higher TBR (2.5/1.8, p < 0.001, 60 min) and VS (1.3/0.7, p < 0.05, tumor) compared to [18F]FET and LA indicated reversible binding. VT increased (p < 0.001, tumor, 21 to 28 days) for [18F]FET (0.5–1.4) and [18F]fluciclovine (0.84–1.5).

Conclusion
[18F]rhPSMA-7.3 showed to be a potential candidate to investigate the tumor microenvironment of GBM. Following PKM, this uptake was associated with tumor vascularization. In contrast to what is known from PSMA-PET in prostate cancer, reversible binding was found for [18F]rhPSMA-7.3 in GBM, contradicting cellular trapping. Finally, [18F]fluciclovine was superior to [18F]FET rendering it more suitable for PET imaging of GBM.
Augenärztliche Versorgung ehemaliger früh- und reifgeborener Personen im Erwachsenenalter – Ergebnisse der Gutenberg Prematurity Eye Study (GPES)
Authors: Fieß Achim , Wacker Annika , Gißler Sandra , Fauer Agnes , Mildenberger Eva , Urschitz Michael S. , Elflein Heike , Stoffelns Bernhard , Pfeiffer Norbert , Schuster Alexander K. 
Published: November 2022

Zusammenfassung
Hintergrund
Frühgeburtlichkeit und das Auftreten der Frühgeborenenretinopathie (ROP) erhöhen das Risiko für das Auftreten von amblyogenen Risikofaktoren in der Kindheit und Jugend.

Ziel der Arbeit
Das Ziel der vorliegenden Studie war die Beschreibung der augenärztlichen Versorgung und der Augenerkrankungen ehemaliger früh- und reifgeborener Personen im Erwachsenenalter.

Material und Methoden
Die Gutenberg Prematurity Eye Study (GPES) ist eine retrospektive Kohortenstudie mit einer prospektiven augenärztlichen Untersuchung von ehemaligen früh- und reifgeborenen Personen, geboren zwischen 1969 und 2002 (aktuelles Alter 18 bis 52 Jahre). Alle Teilnehmenden wurden hinsichtlich amblyogener Parameter wie z. B. dem Vorliegen eines Strabismus und von Refraktionsfehlern untersucht. Die Teilnehmenden wurden gruppiert in Personen mit normalem Gestationsalter (GA) ≥ 37 (Kontrollgruppe), Frühgeborene ohne ROP mit GA 33–36 (Gruppe 2), GA 29–32 (Gruppe 3), GA ≤ 28 Wochen (Gruppe 4) und solche mit ROP ohne Behandlung (Gruppe 5) und mit ROP mit Behandlung (Gruppe 6). Es wurde von allen Teilnehmenden erhoben, wie oft sie innerhalb der letzten 12 Monate bei einer augenärztlichen Untersuchung gewesen sind.

Ergebnisse
Insgesamt wurden die Daten von 140 reifgeborenen und 310 frühgeborenen Erwachsenen in die vorliegende Studie eingeschlossen. Ein Strabismus lag bei 2,1 % (3/140), 6,6 % (9/137), 17,4 % (16/92), 11,1 % (2/18), 27,1 % (13/48) und 60 % (9/15) in den jeweiligen Gruppen 1 bis 6 vor. Der Anteil an Probanden mit augenärztlicher Untersuchung innerhalb der letzten 12 Monate war in den Gruppen der extrem Frühgeborenen mit und ohne ROP im Vergleich zur Kontrollgruppe am höchsten. Insgesamt waren 33,3 % (1/3) der Reifgeborenen und 57,1 % (28/49) der Frühgeborenen mit Strabismus und 0 % (0/3) der Reifgeborenen und 46,9 % (15/32) der Frühgeborenen mit Amblyopie innerhalb der letzten 12 Monate bei einer augenärztlichen Untersuchung.

Diskussion
Extrem frühgeborene Personen mit und ohne postnatale ROP zeigten die höchste Rate an Augenerkrankungen sowie die höchste Rate an augenärztlichen Kontrolluntersuchungen innerhalb der letzten 12 Monate. Dies deutet darauf hin, dass extrem frühgeborene Personen insbesondere mit postnataler ROP insgesamt lebenslang häufigere augenärztliche Kontrolluntersuchungen wahrnehmen.
Ten-year clinical performance of non-precious metal double crowns with friction pins in severely reduced dentitions—a retrospective study
Authors: Hinz Sebastian , Bömicke Wolfgang , Schweyen Ramona , Bensel Tobias 
Published: November 2022

Abstract
Objectives
This follow-up study aimed at collecting long-term data for removable partial dentures (RPDs) retained by double crowns with spark-eroded friction pins (DCP) and comparing them in the presence of severely reduced dentition (SRD) and non-SRD (NSRD, i.e. residual dentition with more than three abutment teeth) after a 10-year wearing period.

Materials and methods
A total of 158 participants (n = 71, 44.9% women) aged 62.5 ± 12.7 years with 182 prostheses on 520 abutment teeth were followed up between 2006 and 2022. The SRD group included 144 RPDs supported by 314 abutment teeth. The data collection was performed retrospectively. 10-year survival rates of RPDs and abutment teeth were determined using the Kaplan–Meier method and compared using the log-rank test for SRD and NSRD, among others. Cox regression analyses were conducted to isolate risk factors for the survival of both RPDs and abutment teeth.

Results
The 10-year cumulative survival rate of all abutment teeth was 65.6% with significantly lower values in the SRD group (53.5%) (p < 0.001). The survival rate for all RPDs was 65.5%. The SRD group showed lower survival rates (57.9%) (p = 0.004). The number and location of the abutment teeth had a significant influence on the survival rates of the RPDs and the abutment teeth. Age, sex, jaw, relining, and vitality had a significant influence on the abutment teeth survival rates.

Conclusions
RPDs showed an acceptable clinical survival rate after 10 years. The number, location, and vitality of abutment teeth were factors that influenced the survival of both RPDs and abutment teeth.

Clinical relevance
Consideration of the influencing factors found can help improve the prognostic assessment of double crown-retained dentures in the context of prosthetic therapy planning.
Effects of sterilization methods on the survival of pathogenic bacteria in potting soil stored at various temperatures
Authors: Hyun Jeong-Eun , Lee Su-Bin , Jung Do-Young , Kim Se-Ri , Choi Song-Yi , Hwang Injun 
Published: November 2022

AbstractFresh food products can be contaminated with pathogenic bacteria in various agricultural environments. Potting soil is sterilized by heat sterilization and then reused. This study evaluated the effects of three sterilization methods (non-sterilized, pasteurized, and sterilized) on the survival of pathogenic bacteria in potting soil during storage for 60 days at 5, 15, 25, and 35 °C. The reduction in Escherichia coli O157:H7, Salmonella Typhimurium, and Staphylococcus aureus in potting soil was higher at higher temperatures (25 and 35 °C) than at lower temperatures (5 and 15 °C). The population of pathogenic bacteria in pasteurized and sterilized potting soil was reduced below the detectable levels within 30 days at 35 °C. In contrast, the population of Bacillus cereus did not change in potting soil during storage for 60 days at all temperatures. These results indicate that sterilization and storage temperature of potting soil are critical factors influencing the survival of pathogenic bacteria.