bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poetry and Poetics in Gilles of Corbeil and Gentile da Foligno’sCarmina de urinarum iudiciis
Authors: Fritz-Morkin Maggie 
Published: May 2022

AbstractSome medical treatises from medieval France and Italy demonstrate surprising rhetorical exuberance, especially in the paratexts where an authorial persona can emerge in the first person. This essay launches from the scatological metaphors and epithets in the exordia of works and commentaries by the physicians Archimattheus, Gilles of Corbeil, and Gentile da Foligno. In captationes benevolentiae styled after Ciceronian precepts, these authors attack their rivals before presenting their own superior science. Their scurrilous invectives—“Hoc salernitani cacantes sanitatem nominant!” (This is what the shitting Salernitans call health!); “discursores alienis fecibus imbuti” (vagrants steeped in other dreck)—tap into carnivalesque modes where excrement is organic, filthy, vituperative, and comic, in contrast to the sterility of the treatises’ technical, Scholastic discourse. A close reading of Gilles’s twelfth-century Carmina de urinarum iudiciis (Songs on Judging Urine) and Gentile’s fourteenth-century commentary on this verse treatise shows that both of these experts in uroscopy tie their excremental imagery into a nuanced poetics that extends from the paratexts into the heart of the work. Both writers demonstrate acute metaliterary sensibility, and respectable training in classical and medieval theories of rhetoric and poetry. Gilles defends his choice to write in verse through a constellation of metaphors pitting the synthetic clarity of both urine and poetry against the muddled confusion of feces and prose. He further ennobles his work by comparing the hermeneutics of uroscopy with allegorical interpretation. Gentile assumes the role of exegete, interpreting Gilles’s verses and unveiling their philosophical and theoretical underpinnings.
The Physician’s Species
Authors: Johnson Joseph R. 
Published: May 2022

AbstractWhat is the physician’s species? In the vernacular beast fables and so-called beast epics that suddenly flourished in the twelfth century, medical (mal)practice forms a central concern. Nearly a tenth of the stories in Marie de France’s Aesopian fable collection deal with illnesses and their treatments; the Roman de Renart, for its part, finds Doctor Fox using his aura of medical authority to torture his fellow animals as part of a cruel and prolonged “cure.” Through an extended analysis of the figure of the doctor, who stands at the center of many of these medical narratives, this article argues that such texts draw their readers into the logic of the “animal clinic”: a conceptual space in which stakes of species difference and predation circulate alongside genuine medical knowledge, with the resulting instability calling into question everything from the nature of the cure to the desire of the sovereign.
Chronicle Conditions
Authors: Singer Julie 
Published: May 2022

AbstractSociological research on chronic illness, and especially on the autobiographical writings of modern patients, has yielded insights into how chronic conditions alter fundamental relationships between notions of self, body, and time. The chronic part of “chronic illness” can disrupt perceptions of the linearity of time, yielding alternate temporalities grounded in bodily experience. In contemporary self-fiction, to chronicle a chronic condition is to juggle different kinds of time. But what about genres, like premodern historiography, that impose a linear, chronological framework? What is at stake when the narrative temporality of a medieval chronicle is filtered through the disrupted temporalities of a chronically impaired subject? This article interrogates these questions through the works of Gilles li Muisis (1272–1353). A Tournaisian abbot, Gilles authored both a Latin chronicle and of a set of vernacular poems situating his writerly activity within a very specific corporeal context: he writes both poetry and chronicle after cataracts have so impaired his vision that he can no longer carry out his administrative duties at the abbey of Saint-Martin—and, remarkably, he abandons his writing after a successful surgery restores his eyesight. The ways in which Gilles talks about his own bodily condition, in both the chronicle and the poems, constitute an elaborate metadiscursive frame whose ultimate effect is to construct the project of the chronicler as a kind of self-writing avant la lettre. With readings of both the Latin and the vernacular works, this essay shows that the chronicle is achieved through a series of subtle chronological and sensory displacements: Gilles’s chronic condition has enabled him to create an anachronic subject-position, outside of both linear historiographical time and the “body-time” of his impairment.
Learning to Value Girls: Balanced Infant Sex Ratios at Higher Parental Education in the United States, 1969–2018
Authors: Rauscher Emily , Song Haoming 
Published: May 2022

Abstract
Infant sex ratios that differ from the biological norm provide a measure of gender status inequality that is not susceptible to social desirability bias. Ratios may become less biased with educational expansion through reduced preference for male children. Alternatively, bias could increase with education through more access to sex-selective medical technologies. Using National Vital Statistics data on the population of live births in the United States for 1969–2018, we examine trends in infant sex ratios by parental race/ethnicity, education, and birth parity over five decades. We find son-biased infant sex ratios among Chinese and Asian Indian births that have persisted in recent years, and regressions suggest son-biased ratios among births to Filipino and Japanese mothers with less than a high school education. Infant sex ratios are more balanced at higher levels of maternal education, particularly when both parents are college educated. Results suggest greater equality of gender status with higher education in the United States.
The Link between Democratic Institutions and Population Health in the American States
Authors: Pacheco Julianna , LaCombe Scott 
Published: May 2022

AbstractContext: This project investigates the role of state-level institutions in explaining variation in population health in the American states. Although cross-national research has established the positive effects of democracy on population health, little attention has been given to subnational units. The authors leverage a new data set to understand how political accountability and a system of checks and balances are associated with state population health.Methods: The authors estimate error correction models and two-way fixed effects models to estimate how the strength of state-level democratic institutions is associated with infant mortality rates, life expectancy, and midlife mortality.Findings: The authors find institutions that promote political accountability are associated with lower infant mortality across the states, while those that promote checks and balances are associated with longer life expectancy. They also find that policy liberalism is associated with better health outcomes.Conclusions: Subnational institutions play an important role in population health outcomes, and more research is needed to understand the link between democracy and health. The authors are the first to explore the link between democratic institutions and population health within the United States, contributing to both the social science literature on the positive effects of democracy and the epidemiological literature on subnational health outcomes.
Challenges with Defining Pharmaceutical Markets and Potential Remedies to Screen for Industry Consolidation
Authors: Feldman Robin , Fulton Brent D. , Godwin Jamie R. , Scheffler Richard M. 
Published: May 2022

Abstract
Context: Dramatic increases in pharmaceutical merger and acquisition (M&A) activity since 2010 suggest we are in the midst of a third wave of industry consolidation.
Methods: The authors reviewed 168 economic, legal, medical, industry, and government sources to examine the effects of consolidation on competition and innovation and to explore how industry attributes complicate M&A regulation in a pharmaceutical context.
Findings: The authors find that, in spite of certain metrics that might argue otherwise, consolidation consistently reduces innovation and harms the public good. They also find that several factors within the pharmaceutical industry impede proper evaluation of proposed mergers. Because consumer choice across substitutes is limited, pharmaceutical markets frustrate conventional methods of defining markets. Volume bargaining in the pharmaceutical supply chain and asset managers’ common ownership of pharmaceutical firms further complicate the definitional process. Hence, the Herfindahl-Hirschman Index (HHI), one measure used by the Federal Trade Commission and the Department of Justice to screen for concerning M&A activity, sometimes depends on faulty market definitions and fails to capture the implications of consolidation for future market share.
Conclusions: The authors describe ways to improve how pharmaceutical markets are defined, highlight quantitative alterations to HHI to account for common ownership, and propose areas requiring further research.
Embracing the “Workshop of Filthy Creation”
Authors: Effinger Elizabeth 
Published: May 2022

AbstractThis article describes a creative public humanities project undertaken to mark the two hundredth anniversary of the publication of Mary Shelley's Frankenstein that transformed the entire novel into an erasure poem made by incarcerated and nonincarcerated participants. The article traces its genesis, outlines the pedagogies that informed it, and closely reads one image from the erasure poem as a touchstone for reflecting on the lessons learned from the project. It also addresses the absence of critical discussions of failure in the discourse of the public humanities.
Arabidopsis root responses to salinity depend on pectin modification and cell wall sensing
Authors: Gigli-Bisceglia Nora , van Zelm Eva , Huo Wenying , Lamers Jasper , Testerink Christa 
Published: May 2022

ABSTRACT
Owing to its detrimental effect on plant growth, salinity is an increasing worldwide problem for agriculture. To understand the molecular mechanisms activated in response to salt in Arabidopsis thaliana, we investigated the Catharanthus roseus receptor-like kinase 1-like family, which contains sensors that were previously shown to be involved in sensing the structural integrity of the cell walls. We found that herk1 the1-4 double mutants, lacking the function of HERKULES1 (HERK1) and combined with a gain-of-function allele of THESEUS1 (THE1), strongly respond to salt application, resulting in an intense activation of stress responses, similarly to plants lacking FERONIA (FER) function. We report that salt triggers pectin methyl esterase (PME) activation and show its requirement for the activation of several salt-dependent responses. Because chemical inhibition of PMEs alleviates these salt-induced responses, we hypothesize a model in which salt directly leads to cell wall modifications through the activation of PMEs. Responses to salt partly require the functionality of FER alone or HERK1/THE1 to attenuate salt effects, highlighting the complexity of the salt-sensing mechanisms that rely on cell wall integrity.
CHIQUITA1 maintains the temporal transition between proliferation and differentiation in Arabidopsis thaliana
Authors: Bossi Flavia , Jin Benjamin , Lazarus Elena , Cartwright Heather , Dorone Yanniv , Rhee Seung Y. 
Published: May 2022

ABSTRACT
Body size varies widely among species, populations and individuals, depending on the environment. Transitioning between proliferation and differentiation is a crucial determinant of final organ size, but how the timing of this transition is established and maintained remains unknown. Using cell proliferation markers and genetic analysis, we show that CHIQUITA1 (CHIQ1) is required to maintain the timing of the transition from proliferation to differentiation in Arabidopsis thaliana. Combining kinematic and cell lineage-tracking studies, we found that the number of actively dividing cells in chiquita1-1 plants decreases prematurely compared with wild-type plants, suggesting CHIQ1 maintains the proliferative capacity in dividing cells and ensures that cells divide a specific number of times. CHIQ1 belongs to a plant-specific gene family of unknown molecular function and genetically interacts with three close members of its family to control the timing of proliferation exit. Our work reveals the interdependency between cellular and organ-level processes underlying final organ size determination.
Complementary and alternative system of medicine for type 2 diabetes mellitus and its complications: A scoping review
Authors: Parsekar Shradha S , Gudi Nachiket , Walke Sujata Chodankar , Shaw Prabhu Dutta , Hombali Aditi , Nayak Anupama V , Hadapad Basavaraj S 
Published: May 2022

Background: This review aims to map the evidence on the effectiveness of Complementary and Alternative Medicine (CAM) for Type 2 Diabetes Mellitus (T2DM) and its associated complications and identify research gaps in key outcomes and CAMs. Methods: We followed the Johanna Briggs Institute guidelines to undertake this scoping review. We carried out a comprehensive search from inception to March 2020 in electronic databases and registers. Forward and backward citations of included studies were also searched. The randomized controlled trials (RCTs) and non-randomized studies with intervention and control arm were mapped based on the effectiveness of various CAM (Yoga, Ayurveda, Homeopathy, Siddha, Naturopathy, Unani, and Sowa-rigpa) on outcomes among individuals with prediabetes or metabolic syndrome, T2DM with and without any comorbidities. Results: A total of 249 studies were included after screening 3798 citations. Most of the included studies were conducted in India and Iran. Most frequently studied CAM interventions include Yoga, Ayurveda, and herbal products as compared to other CAM therapies. Conclusion: Although we identified a lot of literature on the effectiveness of CAMs for T2DM, there is a lack of standardization of preparation of these medicines and the interventional modalities. To validate the potential benefits of CAM, robust research with high-quality RCTs and systematic reviews are needed to bridge the gap of evidence in CAM therapies. Future investments for research in CAM may focus on assessing the quality of existing trials and finding out an optimal dose, frequency, and duration of CAM, both as an alternative and complementary approach.
A Review of Wound Healing Mechanisms of Natural Products in Keratinocyte Cells
Authors: Fristiohady Adryan , Asasutjarit Rathapon , Julian Purnama La Ode Muh. , Al-Ramadan Wirhamsah 
Published: May 2022

Background: The skin is the largest organ of the human body, around 15% of the body weight consisting of the epidermis, dermis, and subcutaneous. The skin's primary function is to protect our body from external factors that can harm the body by forming a protective barrier that covers the body. This review aims to provide insights related to wound-healing mechanisms of several plants in HaCat cells. Methods: The literature study method used, both from primary and secondary libraries. The library search was conducted using online-based library search instruments from 2009 to 2021, such as NCBI-PubMed and Google Scholar. Results: The wound-healing mechanism includes processes that restore skin integrity through four stages: hemostasis, inflammation, multiplication, and remodeling. Many plants have been studied to have activity in wound-healing by various mechanisms. Conclusions: Therefore, it is essential to research wound-healing mechanisms to find treatments sourced from natural compounds.
Testosterone level correlates significantly with luteinizing hormone to follicle-stimulating hormone ratio among women with polycystic ovary syndrome: A cross sectional study
Authors: Alhassan Samia Mohammed , Elmugadam Abdelgadir , Abubaker Nuha Eljaili , Elfadil Ghada A. 
Published: May 2022

Background: Polycystic ovary syndrome (PCOS), an endocrinological problem among women in the reproductive age, is characterized by chronic ovulatory dysfunction, hyperandrogenism, and elevated luteinizing hormone: follicle stimulating hormone (LH-FSH) ratio. The goal of this study was to examine if the blood LH-FSH ratio and total testosterone (TT) levels in Sudanese women with PCOS were linked. Methods: This cross-sectional study included 300 women with confirmed PCOS based on Rotterdam criteria. PCOS women mean (standard deviation): age 29.1(5.8) years; body mass index (BMI) 27.9±4.6 kg/m2. Each participant underwent a clinical history, physical examination, and ovaries ultrasonogram. ASYS Expert Plus Microplate was used to quantify serum LH, FSH, and TT levels in fasting blood specimen drawn during the follicular phase of the menstrual cycle of women with PCOS. Results: More than two-thirds of the participants (71.0%) had an aberrant LH-FSH ratio (cut-off>1.0), and 58.3% had hyperandrogenemia (TT>109.5 ng/dL). Hyperandrogenemic women had significantly increased LH-FSH ratio (P= 0.000). The LH-FSH ratio and serum TT were significantly positive correlated (r= 0.329, P= 0.000). Overall, 52.0% of women with PCOS exhibited menstrual cycle irregularity, and 59.0 % had a positive family history of PCOS. On logistic regression analysis, the LH-FSH ratio (odds ratio (OR) (95% confidence interval (CI)): 2.308 (1.698- 3.139, P= 0.000) was found to be positively related to hyperandrogenemia independently. Furthermore, when the LH-FSH ratio is greater than one, hyperandrogenemia can be distinguished from normoandrogenemia, area under the curve (AUC) = 0.726, P= 0.000, 95% CI: (0.668-0.785) with a serum TT threshold of 109.5 ng/dL (sensitivity 70.0%, specificity 77.1%). Conclusions: In Sudanese women with PCOS, the serum LH-FSH ratio and TT have a strong relationship. Furthermore, LH-FSH ratio of greater than one can be used to distinguish between hyperandrogenic and non-hyperandrogenic PCOS women.
Linking family planning market census data with consumer experiences in three countries: the Consumer’s Market for Family Planning study protocol and data
Authors: Conlon Mark , Buyungo Peter , Njogu Julius , Nwala Anthony , Gibbs Susannah , Wheatley Nkemdiri ,   CM4FP Group
Published: May 2022

Background: The Consumer’s Market for Family Planning (CM4FP) project was designed to address limitations of existing family planning (FP) data sources that prevent a full understanding of the total FP market. CM4FP data provide a picture of the complete supply environment and how consumers experience it. Study objectives were to 1) test a ring-fenced census approach consisting of an outlet census in a defined geographical area and a household survey in a smaller inner ring, to comprehensively map the total FP market in a local geography; 2) explore FP supply market dynamism through longitudinal data collection from contraceptive outlets; and 3) test a methodology for directly linking household and outlet data to measure the relationship between contraceptive demand and supply. Methods: Data were collected from study sites in Nigeria, Kenya, and Uganda from 2019 to 2020. Longitudinal outlet census data and repeated cross-sectional household survey data from women ages 18-49 were collected at three quarterly time points. Outlets were located in an outer ring geography to encompass locations likely visited by women sampled from a smaller inner ring. Data from women who received a contraceptive method in the past 12 months were linked to data for the outlet from which they received the method. Results: Datasets include product audits for 22,380 individual FP products, collected from a total of 1,836 outlets across 12 study sites. The datasets also contain data from 11,536 female respondents, of whom 1,975 were successfully matched to the outlet where they most recently obtained their method. Conclusions: CM4FP data are available at www.cm4fp.org. This unique dataset enables in-depth exploration of the family planning supply market in addition to interactions between the market and consumer perspectives and behaviors within each study site. The data can also be used to explore novel methodologies to inform future study designs.
Asymptotic Optimality of Base-Stock Policies for Perishable Inventory Systems
Authors: Bu Jinzhi , Gong Xiting , Chao Xiuli 
Published: May 2022

We consider periodic review perishable inventory systems with a fixed product lifetime. Unsatisfied demand can be either lost or backlogged. The objective is to minimize the long-run average holding, penalty, and outdating cost. The optimal policy for these systems is notoriously complex and computationally intractable because of the curse of dimensionality. Hence, various heuristic replenishment policies are proposed in the literature, including the base-stock policy, which raises the total inventory level to a constant in each review period. Whereas various studies show near-optimal numerical performances of base-stock policies in the classic system with zero replenishment lead time and a first-in-first-out issuance policy, the results on their theoretical performances are very limited. In this paper, we first focus on this classic system and show that a simple base-stock policy is asymptotically optimal when any one of the product lifetime, demand population size, unit penalty cost, and unit outdating cost becomes large; moreover, its optimality gap converges to zero exponentially fast in the first two parameters. We then study two important extensions. For a system under a last-in-first-out or even an arbitrary issuance policy, we prove that a simple base-stock policy is asymptotically optimal with large product lifetime, large unit penalty costs, and large unit outdating costs, and for a backlogging system with positive lead times, we prove that our results continue to hold with large product lifetime, large demand population sizes, and large unit outdating costs. Finally, we provide a numerical study to demonstrate the performances of base-stock policies in these systems. This paper was accepted by Victor Martinez de Albéniz, operations management. Funding: J. Bu was partially supported by a Hong Kong Polytechnic University Start-up Fund for New Recruits [Grant P0039585]. X. Gong was partially supported by a Chinese University of Hong Kong (CUHK) Direct Grant [Grant 4057147] and the Hong Kong Research Grants Council (RGC) General Research Fund [Grant CUHK14500120]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4400 .