bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the factors affecting participation in natural resources development cooperatives: The case study of Ardabil Province
Authors: Hamidi Ali , Mehrabi Aliakbar , Javadi Seyed Akbar , Imani Aliakbar 
Published: August 2022

AbstractNatural resources development cooperatives (NRDCs) are leading enterprises that develop sustainable community‐based solutions. Basically, such cooperatives attempt to engage beneficiaries in environmental conservation through collective action. However, there exist remarkable shortcomings in administering these types of cooperatives. This paper aims to investigate beneficiaries' willingness to participate and invest in NRDCs based on three educational, economic, and social sections, each represented by their corresponding components, which represent the variables (sub‐factors) of each section. The current research was performed using a descriptive‐survey approach. Semi‐structured interviews were conducted with 63 cooperatives' board members located in Ardabil Province in Iran. Results discovered that three variables of information, participation acceptance rate and top‐down planning from educational factors alongside those of conservation effectiveness and projected outlook from the economic factor significantly affect participation levels in NRDCs. Similarly, the lack of rangeland ownership, cooperatives' limited problem‐solving capabilities, and concerns about environmental conservation of formerly demolished lands, all components of the social section investigated in this study, highly influenced beneficiaries' participation in cooperatives. Correlation coefficient analysis between the efficient factors showed that education levels have no significant relationship with the two remaining factors; however, the economic and social factors positively and significantly (p < 0.01) relate to beneficiaries' participation level. Nonparametric correlation analysis determined that variables from the economic factor analysis, such as the financial capital size, awareness levels, indigenous culture, people's experiences interacting with the administrative bodies of NRDCs, the state‐run economy, and the lack of support for beneficiaries by cooperatives from the social factor analysis each have independent and distinct relationships that affect participation in cooperatives. However, from the educational factor analysis, all variables were influenced reciprocally and were of inferior importance to participation in NRDCs.
Perinatal outcome and long‐term infectious hospitalizations of offspring born to women with known drug allergy
Authors: Mahamid Assil , Wainstock Tamar , Sheiner Eyal , Rosenberg Elli , Kluwgant Dvora , Pariente Gali 
Published: August 2022

AbstractProblemMaternal drug allergy has been associated with altered immune status and an inflammatory environment, which may affect the risk of future infectious diseases in the offspring.ObjectivesWe aimed to evaluate perinatal outcomes and long‐term infectious hospitalization in the offspring of women with documented drug allergy.Method of studyThe study was conducted at the Soroka University Medical Center (SUMC), a tertiary medical center. For perinatal outcomes, generalized estimation equation (GEE) models were used controlling for maternal age, maternal diabetes mellitus, smoking, and hypertensive disorders. The study groups were followed until 18 years of age for infectious‐related hospitalizations. A Kaplan–Meier survival curve was used to compare the cumulative incidence of long‐term infectious hospitalizations. A Cox proportional hazards model was conducted to control for confounders.ResultsDuring the study period, 243 682 deliveries met the inclusion criteria, of which 9756 (4.0%) occurred in women with documented drug allergy. Using GEE, maternal drug allergy was found to be a significant independent risk factor for hypertensive disorders, diabetes mellitus, intra‐uterine growth restriction (IUGR), and preterm delivery. Offspring also had significantly higher rates of long‐term infectious hospitalizations. Kaplan–Meier survival curves demonstrated significantly higher cumulative incidence rates of infectious hospitalization (log‐rank p < .001). In a Cox proportional hazards model, being born to a mother with documented drug allergy was independently associated with infectious hospitalization of the offspring in the long term.ConclusionsMaternal documented drug allergy is independently associated with an adverse perinatal outcome such as IUGR and preterm delivery and increased risk of long‐term infectious hospitalization of the offspring.
Natural killer cell profiles in recurrent pregnancy loss: Increased expression and positive associations with TACTILE and LILRB1
Authors: Habets Denise H. J. , Schlütter Anna , van Kuijk Sander M. J. , Spaanderman Marc E. A. , Al‐Nasiry Salwan , Wieten Lotte 
Published: August 2022

AbstractProblemNK cells are important for healthy pregnancy and aberrant phenotypes or effector functions have been associated with RPL. We compared expression of a broad panel of NK cell receptors, including immune checkpoint receptors, and investigated their clinical association with RPL as this might improve patient stratification and prediction of RPL.Method of studyPeripheral blood mononuclear cells were isolated from 52 women with RPL and from 2 women with an uncomplicated pregnancy for flowcytometric analysis and plasma was used to determine anti‐CMV IgG antibodies.ResultsBetween RPL and controls, we observed no difference in frequencies of T‐, NKT or NK cells, in CD56dimCD16+ or CD56brightCD16‐ NK cell subsets or in the expression of KIRs, NKG2A, NKG2C, NKG2D, NKp30, NKp44, NKp46 or DNAM1. NK cells from women with RPL had a higher expression of LILRB1 and TACTILE and this was associated with the number of losses. The immune checkpoint receptors PD1, TIM3 and LAG3 were not expressed on peripheral blood NK cells. In RPL patients, there was a large variation in NKG2C expression and higher levels could be explained by CMV seropositivity.ConclusionOur study identified LILRB1 and TACTILE as NK cell receptors associated with RPL. Moreover, we provide first support for the potential role of CMV in RPL via its impact on the NK cell compartment. Thereby our study could guide future studies to confirm the clinical association of LILRB1, TACTILE and NKG2C with RPL in a larger cohort and to explore their functional relevance in reproductive success.
Long‐term outcomes of sporadic rectal cancer versus ulcerative colitis‐associated rectal cancer: a matched case‐control study
Authors: Tatar Cihad , Lightner Amy L. , Jia Xue , Liska David , Kalady Matthew , Steele Scott R. , Gorgun Emre 
Published: August 2022

AbstractBackgroundAlthough patients with ulcerative colitis (UC) are at increased risk of rectal cancer compared to the general population, it remains unclear whether their oncologic outcomes are different than sporadic rectal cancer (S‐RC).We aimed to compare survival and oncologic outcomes in S‐RC versus UC‐associated rectal cancer (UC‐RC).MethodsWe performed a retrospective case‐control study of patients who underwent surgical resection for rectal cancer between 2005 and 2015. Data collected included patient demographics, intraoperative variables, postoperative outcomes, and oncological outcomes.ResultsA total of 138 patients were included; 92 patients with S‐RC and 46 with UC‐RC. Both groups were comparable in terms of demographics, oncologic characteristics, oncologic treatment strategies, perioperative complications and operative factors except for preoperative radiotherapy. At a median follow‐up time of 3.7 years the 3‐and 5‐year OS rates; the 1‐and 3‐year DFS rates were comparable between the groups.ConclusionUlcerative colitis‐associated rectal cancer patients have similar survival and oncologic outcomes as sporadic rectal cancer patients.
Effects of hysterectomy on pelvic floor function and sexual function—A prospective cohort study
Authors: Forsgren Catharina , Amato Martina , Johannesson Ulrika 
Published: August 2022

AbstractIntroductionHysterectomy is one of the most common major surgical procedures in women. The effects of hysterectomy on pelvic floor and sexual function are uncertain. Our objective was to investigate the effects of hysterectomy for benign indications on pelvic floor and sexual function and to compare different modes of surgery.Material and methodsWe performed a prospective clinical cohort study. In all, 260 women scheduled for hysterectomy answered validated questionnaires (Pelvic Floor Impact Questionnaire, Pelvic Floor Distress Inventory and Female Sexual Function Index). Participants were followed 6 months and 1 year after surgery. Data were analyzed using nonparametric statistics and mixed effect models.ResultsWomen with subtotal hysterectomy, vaginal hysterectomy, laparoscopic assisted vaginal hysterectomy, and previous prolapse/incontinence surgery were excluded from further analysis, leaving the remaining cohort to 242 patients. The response rate at 6 months and 1 year follow‐up was 180/242 (74.3%) and 169/242 (69.8%), respectively. There was an improvement of pelvic floor function at both follow‐ups; mean score of Pelvic Floor Impact Questionnaire at baseline was 42.5 (51.7), at 6 months 19.9 (42.2) and at 1 year 23.7 (50.3) (p < 0.001). The mean score of Pelvic Floor Distress Inventory at baseline was 69.6 (51.1), at 6 months 49 (43.2) and at 1 year 49 (43.2) (p < 0.001). There was an improvement of sexual function after 6 months (mean score of Female Sexual Function Index at baseline 17.9 [SD 11.7] and at 6 months 21.0 [SD 11.7]) (p < 0.001). There was no difference in pelvic floor or sexual function when comparing surgical techniques.ConclusionsRobotic assisted laparoscopic hysterectomy, laparoscopic hysterectomy and abdominal hysterectomy improve pelvic floor function to the same extent at 6 months and 1 year after surgery. There was an overall improvement of sexual function 6 months after hysterectomy, but this did not persist after 1 year.
Clinical characteristics and risk factors of myopic retinoschisis in an elderly high myopia population
Authors: Li Menghan , Yu Jiayi , Chen Qiuying , Zhou Hao , Zou Haidong , He Jiangnan , Zhu Jianfeng , Fan Ying , Xu Xun 
Published: August 2022

AbstractPurposeTo investigate the clinical characteristics, internal correlations and risk factors for different locations of retinoschisis (RS) in an elderly high myopia (HM) population.MethodsA total of 448 eyes (304 participants) were analysed and classified into no retinoschisis (no‐RS), paravascular retinoschisis (PVRS), peripapillary retinoschisis (PPRS) and macular retinoschisis (MRS) groups. Each participant underwent comprehensive ophthalmic examinations, and posterior scleral height (PSH) was measured in swept‐source optical coherence tomography images. PSH, vitreoretinal interface abnormities and myopic atrophy maculopathy (MAM) were compared among groups.ResultsRetinoschisis was found in 195 (43.5%) eyes, among which 170 (37.9%) had PVRS, 123 (27.5%) had PPRS, and 103 (23.0%) had MRS. MRS was found to be combined with PVRS in 96 of 103 (93.2%) eyes. MAM was one of the risk factors for RS (odds ratio [OR], 2.459; p = 0.005). Higher nasal PSH was the only risk factor for PVRS (OR, 9.103; p = 0.008 per 1‐mm increase). Elongation of axial length (AL) (OR, 1.891; p < 0.001 per 1‐mm increase), higher PSH in nasal (OR, 5.059; p = 0.009 per 1‐mm increase) and temporal (OR, 13.021; p = 0.012 per 1‐mm increase), epiretinal membrane (ERM; OR, 2.841; p = 0.008) and vitreomacular traction (VMT; OR, 7.335; p = 0.002) were risk factors for MRS.ConclusionsParavascular retinoschisis is the most common type of RS in HM and MRS is mostly combined with PVRS. MAM is one of the risk factors for RS. In addition to longer AL and higher PSH, the presence of VMT and ERM also play an important role in the formation of MRS.
Retinal oxygen saturation in monoclonal gammopathies patients: A pilot study
Authors: Hübnerová Petra , Karhanová Marta , Krhovská Petra , Minařík Jiří , Mlčák Petr , Pašková Barbora , Schreiberová Zuzana , Šínová Irena , Zapletalová Jana , Šín Martin 
Published: August 2022

AbstractPurposeThe aim of this pilot study was to assess oxygen saturation in retinal blood vessels in patients with monoclonal gammopathies (MGs).MethodsThirty‐one patients with MGs (11 women and 20 men, mean age 65.9 ± 8.9 years) were enrolled during 2016–2020. The patients were diagnosed at the Haemato‐Oncology Department and subsequently examined at the Ophthalmology Department before initiating systemic therapy. All patients were subjected to automatic retinal oximetry (Oxymap ehf.) and had their fundus photographed (Topcon TRC‐50DX retinal camera). We assessed the association between retinal oxygen saturation (SatO2) – arterial SatO2, venous SatO2 and arterio‐venous (AV) difference—and MGs parameters: serum monoclonal immunoglobulin (M‐protein) level and serum immunoglobulin‐free light chains (FLC kappa and lambda), total protein, serum viscosity, haemoglobin, albumin, lactate dehydrogenase, C‐reactive protein, creatinine and serum calcium level. Hyperviscosity‐related retinopathy was also evaluated.ResultsStatistical analysis showed a significant positive correlation (r = 0.462; p = 0.009) between the AV difference and the haemoglobin level. A significant, medium strong negative correlation was found between the AV difference and the serum levels of the monoclonal light lambda chains (r = −0.450; p = 0.011). Contrary to expectations, no statistically significant correlation was found between retinal oxygen saturation and the total protein or viscosity.ConclusionThis study found correlation between retinal oxygen saturation and certain parameters in the blood of patients with MGs. Increasing levels of monoclonal immunoglobulin seem to reduce oxygen absorption in retinal arterioles, resulting in a lower AV difference, particularly in patients with a high free light chain level.
Survey showed that very few paediatric residents in Southwest Nigeria were interested in specialising in gastroenterology
Authors: Senbanjo Idowu O. , Abolurin Olufunmilola O. , Ezegamba Comfort O. , Akinbami Felix O. , Allen Stephen J. 
Published: August 2022

AbstractAimPaediatric gastroenterology remains an under‐recognised sub‐speciality in Africa. We determined the preferred sub‐specialities among paediatric residents in Southwest Nigeria and what influenced whether they chose paediatric gastroenterology.MethodsThis was a cross‐sectional survey of paediatric residents in seven teaching hospitals in Southwest Nigeria. A self‐administered questionnaire was used to obtain information on their socio‐demographics, educational attainment, choice of sub‐speciality and the factors influencing that choice.ResultsOf 144 eligible paediatric residents, 124 (86.1%) completed the survey. Their mean age was 35.0 ± 1.7 years, and 83 (66.9%) were females. The majority (94.4%) had already chosen their sub‐speciality, and nearly two‐thirds (65.0%) made the decision during training. The most popular sub‐speciality was neonatology (30.6%), and only three (2.4%) residents chose gastroenterology. Factors influencing the choice of sub‐speciality were perceived ability (85.3%) and academic experience (83.8%). Financial reasons were less frequent (32.5%). Lack of diagnostic equipment (30.6%) and role models (21.0%) were the most frequent reasons for residents being disinterested in paediatric gastroenterology.ConclusionFew residents were interested in paediatric gastroenterology and there is a need to encourage interest in this subject at an early stage in their training and provide more diagnostic equipment and greater mentorship.
To forgive or not to forgive an organisation: Perceived integrity versus competence transgressions shape consumers' forgiveness of transgressing organisations
Authors: Noor Masi , Chao Melody M. , Doosje Bertjan 
Published: August 2022

AbstractForgiveness can de‐escalate conflicts and transform resentment into constructive responses. Although we have learned much about interpersonal and intergroup forgiveness in the last two decades (Fehr et al., 2010; Noor, 2016; Van Tongeren et al., 2014), we still know little about the dynamics underpinning individuals' forgiveness of organisational transgressions. We report two studies that investigated the importance of perceived transgression types (lack of integrity vs. lack of competence vs. control) in determining forgiveness towards transgressing organisations. In both studies, organisations were less forgivable when their transgressions were attributed to the lack of integrity (vs. competence or control condition). Forgiveness mediated the negative impact of transgression on punitiveness, highlighting the buffering role of forgiveness in the aftermath of organisational failings. Our findings generalised across both public and private organisations, different designs and cultural contexts.
Incidence and preventability of hospital admissions for adverse drug reactions in France: A prospective observational study (IATROSTAT)
Authors: Laroche Marie‐Laure , Gautier Sophie , Polard Elisabeth , Rabier Marie‐Blanche , Chouchana Laurent , Lebrun‐Vignes Bénédicte , Faillie Jean‐Luc , Petitpain Nadine , Lagarce Laurence , Jonville‐Bera Annie‐Pierre ,   for the IATROSTAT study group
Published: August 2022

AimsIn the last French study in 2007, the incidence of hospital admissions (HAs) related to adverse drug reactions (ADRs) was 3.6%. The objective was to assess the current ADR‐HA incidence in France and to describe both its characteristics and preventability.MethodsA prospective multicentre study was conducted among randomly selected French public hospital medical wards (April–July 2018). Patients admitted during a week period were included. ADR‐HA cases were collected by the French Regional Pharmacovigilance Centres network. An independent committee validated potential cases and ADR preventability.ResultsADR‐HA incidence was 8.5% (95% confidence interval [CI]: 7.6–9.4%), increasing with age (3.3% [95%CI: 1.8–5.5%] ≤16 y vs. 10.6% [95%CI: 9.3–12.0%] ≥65 y). The most common ADRs were haemorrhagic events (8.8%), haematological disorders (6.5%), acute renal failure (6.3%), fluid and electrolyte disorders (6.0%), and falls (5.2%). New drugs were involved: targeted therapies (22.8% of antineoplastics), direct oral anticoagulants (29.6% of antithrombotics) and incretin‐based drugs (20.0% of antidiabetics). ADRs were preventable in 16.1% of cases because the drugs involved had not been used in accordance with monographies, package leaflets or other therapeutic guidelines. The main situations of noncompliance addressed either dose or duration of use (27.9%), warning (23.2%), use precaution (18.6%) and inappropriate self‐medication or misuse by patients (11.6%).ConclusionIn France, ADR‐HA incidence dramatically increased over the last decade. A significant proportion was related to new pharmacological classes and considered as preventable. These findings should lead to in‐depth thought on preventive actions on at‐risk drug classes.
Effectiveness of endoscopic screening for gastric cancer: The Japan Public Health Center‐based Prospective Study
Authors: Narii Nobuhiro , Sobue Tomotaka , Zha Ling , Kitamura Tetsuhisa , Iwasaki Motoki , Inoue Manami , Yamaji Taiki , Tsugane Shoichiro , Sawada Norie 
Published: August 2022

AbstractUpper gastrointestinal endoscopy for gastric cancer screening has been implemented in Japan. However, its effectiveness for gastric cancer prevention has not been fully studied. We aimed to investigate the effectiveness of endoscopic screening to reduce mortality from gastric cancer. In a large prospective population‐based cohort study including 80,272 participants, we compared the risk of mortality and incidence of gastric cancer among participants who underwent endoscopic or radiographic screening compared with those who did not undergo any screening using multivariable Cox proportional hazards models. In the 1,023,364 person‐year observation period (median; 13.0 years), 1977 cases of gastric cancer were diagnosed, and 783 patients with gastric cancer died. In the endoscopic screening group, the mortality from gastric cancer and incidence of advanced gastric cancer were reduced by 61% (hazard ratio [HR] = 0.39 [95% CI: 0.30–0.51]) and 22% (HR = 0.78 [95% CI: 0.67–0.90]), respectively. The radiographic screening reduced the mortality from gastric cancer (HR = 0.63 [95% CI: 0.54–0.73]), but its effectiveness was lower than that of endoscopic screening. In conclusion, endoscopic screening reduced the incidence of advanced gastric cancer and mortality from gastric cancer in the Japanese population.
Efficient Sufficiency: A qualitative evaluation of a 1 year pilot study of young people and parents accessing a mental health drop‐in centre in a paediatric hospital
Authors: Catanzano Matteo , Bennett Sophie D. , Fifield Kate , Xu Laila , Sanderson Charlotte , Coughtrey Anna E. , Kerry Ellie , Liang Holan , Heyman Isobel , Shafran Roz 
Published: August 2022

AbstractBackgroundChildren and young people with long‐term physical health conditions (LTC) are known to have higher levels of co‐morbid mental health problems than medically healthy children. Evidence‐based treatments for mental health problems are effective in children who also have an LTC. This study aimed to explore the factors associated with participants' perceived acceptability and impact of a transdiagnostic mental health centre offering brief psychological assessment and treatment for children and young people and/or their families with mental health needs in the context of long term physical conditions.MethodsOne‐hundred twenty‐eight patients attending the drop‐in centre were invited to participate. Overall, 35 participated (31 parents/carers; 4 children and young people) in semi‐structured interviews (either in person or by phone) exploring their experience of the centre. Interviews were audio‐recorded, transcribed and checked. Framework analysis was then conducted on all transcripts.ResultsOverall, participants found the drop‐in centre highly acceptable and reported a positive experience. Reasons for this varied but broadly focused around four themes: (1) efficient sufficiency; (2) autonomy; (3) fusion of process and content factors and (4) (dis)parities of esteems and ‘seeing both sides of the coin’.ConclusionsParticipants found the intervention acceptable. A mental health drop‐in centre in a paediatric hospital appears to be a positive and valued adjunct to supplement existing mental health services.
The future is present in the past: A meta‐analysis on the longitudinal associations of parent–adolescent relationships with peer and romantic relationships
Authors: Schulz Susanne , Nelemans Stefanie , Hadiwijaya Hana , Klimstra Theo , Crocetti Elisabetta , Branje Susan , Meeus Wim 
Published: August 2022

AbstractPositive peer and romantic relationships are crucial for adolescents' positive adjustment and relationships with parents lay the foundation for these relationships. This longitudinal meta‐analysis examined how parent–adolescent relationships continue into later peer and romantic relationships. Included longitudinal studies (k = 54 involving peer relationships, k = 38 involving romantic relationships) contained demographically diverse samples from predominantly Western cultural contexts. Multilevel meta‐regressions indicated that supportive and negative parent–adolescent relationships were associated with supportive and negative future peer and romantic relationships. Meta‐analytic structural equation modeling (k = 54) indicated that supportive parent–adolescent relationships unidirectionally predicted supportive and negative peer relationships, while negative parent–adolescent relationships were bidirectionally associated with supportive and negative peer relationships. Maintaining mutually supportive relationships with parents may help adolescents to develop positive social relationships.