bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Battle of the Titans—Comparing Resuscitation Between Five Major Burn Centers Using the Burn Navigator
Authors: Rizzo Julie A , Liu Nehemiah T , Coates Elsa C , Serio-Melvin Maria L , Aden James K , Stallings Jonathan D , Foster Kevin N , AbdelFattah Kareem R , Pham Tam N , Salinas Jose 
Published: July 2022

Abstract
The goal of burn resuscitation is to provide the optimal amount of fluid necessary to maintain end-organ perfusion and prevent burn shock. The objective of this analysis was to examine how the Burn Navigator (BN), a clinical decision support tool in burn resuscitation, was utilized across five major burn centers in the United States, using an observational trial of 300 adult patients. Subject demographics, burn characteristics, fluid volumes, urine output, and resuscitation-related complications were examined. Two hundred eighty-five patients were eligible for analysis. There was no difference among the centers on mean age (45.5 ± 16.8 years), body mass index (29.2 ± 6.9), median injury severity score (18 [interquartile range: 9–25]), or total body surface area (TBSA) (34 [25.8–47]). Primary crystalloid infusion volumes at 24 h differed significantly in ml/kg/TBSA (range: 3.1 ± 1.2 to 4.5 ± 1.7). Total fluids, including colloid, drip medications, and enteral fluids, differed among centers in both ml/kg (range: 132.5 ± 61.4 to 201.9 ± 109.9) and ml/kg/TBSA (3.5 ± 1.0 to 5.3 ± 2.0) at 24 h. Post-hoc adjustment using pairwise comparisons resulted in a loss of significance between most of the sites. There was a total of 156 resuscitation-related complications in 92 patients. Experienced burn centers using the BN successfully titrated resuscitation to adhere to 24 h goals. With fluid volumes near the Parkland formula prediction and a low prevalence of complications, the device can be utilized effectively in experienced centers. Further study should examine device utility in other facilities and on the battlefield.
Diminished reality using semantic segmentation and generative adversarial network for landscape assessment: evaluation of image inpainting according to colour vision
Authors: Kikuchi Takuya , Fukuda Tomohiro , Yabuki Nobuyoshi 
Published: July 2022

Abstract
The objective of this research is to develop a method to detect and virtually remove representations of existing buildings from a video stream in real-time for the purpose of visualizing a future scenario without these buildings. This is done by using semantic segmentation, which eliminates the need to create three-dimensional models of the buildings and the surrounding scenery, and a generative adversarial network (GAN), a deep learning method for generating images. Real-time communication between devices enables users to utilize only portable devices equipped with a camera to visualize the future landscape onsite. As verification of the proposed method’s usefulness, we evaluated the complementation accuracy of the GAN and real-time performance of the entire method. The results indicated that the process is completed accurately when the area to be complemented is less than 15% of the view and that the process runs at 5.71 fps. The proposed method enables users to understand intuitively the future landscape and contributes to reducing the time and cost for building consensus.
Country of Origin and Representative Bureaucracy
Authors: Grissom Jason A , Darling-Aduana Jennifer , Hall Richard 
Published: July 2022

Abstract
A large body of research shows that clients of government services benefit from the presence of bureaucrats with whom they share race or ethnicity. These benefits arise from active or symbolic representation, which scholars argue are grounded in the shared backgrounds, language, and values that race and ethnicity proxy. We suggest that these shared connections are likely to be even more salient for clients and bureaucrats who share not just the same ethnicity but the same country of origin, and we look for evidence of representation based on country of origin in the context of public schools. Leveraging administrative and survey data from Miami-Dade County Public Schools, the fourth-largest school district in the United States, we employ regression models with school-by-year fixed effects to test for differences in test scores for students taught by a teacher with the same country of origin relative to similar students taught by other-origin teachers in the same school in the same year. We find that immigrant students with origin-matched teachers score modestly higher than their non-matched peers in both math and reading. These increases are most apparent among low-income students and those who are English learners. Patterns vary by immigrant students’ origin country.
Initial Assessment of a Regional Military–Civilian Partnership on Trauma Surgery Skills Sustainment
Authors: Ruggero John M , Farnand Alex W , Roach Paul B , Starr Frederic , Tadlock Matthew D , Bokhari Faran 
Published: July 2022

ABSTRACT

Introduction
Trauma surgery skills sustainment and maintenance of combat readiness present a major problem for military general surgeons. The Military Health System (MHS) utilizes the knowledge, skills, and abilities (KSA) threshold score of 14,000 as a measure of annual deployment readiness. Only 9% of military surgeons meet this threshold. Most military–civilian partnerships (MCPs) utilize just-in-time training models before deployment rather than clinical experiences in trauma at regular intervals (skills sustainment model). Our aim is to evaluate an established skills sustainment MCP utilizing KSAs and established military metrics.

Materials and Methods
Three U.S. Navy active duty general surgeons were embedded into an urban level-1 trauma center taking supervised trauma call at regular intervals prior to deployment. Operative density (procedures/call), KSA scores, trauma resuscitation exposure, and combat casualty care relevant cases (CCC-RCs) were reviewed.

Results
During call shifts with a Navy surgeon present an average 16.4 trauma activations occurred; 32.1% were category-1, 27.6% were penetrating, 72.4% were blunt, and 33.8% were admitted to the intensive care unit. Over 24 call shifts of 24 hours in length, 3 surgeons performed 39 operative trauma cases (operative density of 1.625), generating 11,683 total KSA points. Surgeons 1, 2, and 3 generated 5109, 3167, and 3407 KSA points, respectively. The three surgeons produced a total of 11,683 KSA points, yielding an average of 3,894 KSA points/surgeon. In total, 64.1% of operations fulfilled CCC-RC criteria.

Conclusions
Based on this initial evaluation, a military surgeon taking two calls/month over 12 months through our regional skills sustainment MCP can generate more than 80% of the KSA points required to meet the MHS KSA threshold for deployment readiness, with the majority being CCC-RCs. Intangible advantages of this model include exposure to multiple trauma resuscitations while possibly eliminating just-in-time training and decreasing pre-deployment requirements.
Patient views regarding cannabis use in chronic kidney disease and kidney failure: a survey study
Authors: Collister David , Herrington Gwen , Delgado Lucy , Whitlock Reid , Tennankore Karthik , Tangri Navdeep , Goupil Remi , Nadeau-Fredette Annie-Claire , Davison Sara N , Wald Ron , Walsh Michael 
Published: July 2022

ABSTRACTBackgroundCannabis is frequently used recreationally and medicinally, including for symptom management in patients with kidney disease.MethodsWe elicited the views of Canadian adults with kidney disease regarding their cannabis use. Participants were asked whether they would try cannabis for anxiety, depression, restless legs, itchiness, fatigue, chronic pain, decreased appetite, nausea/vomiting, sleep, cramps and other symptoms. The degree to which respondents considered cannabis for each symptom was assessed with a modified Likert scale ranging from 1 to 5 (1, definitely would not; 5, definitely would). Multilevel multivariable linear regression was used to identify respondent characteristics associated with considering cannabis for symptom control.ResultsOf 320 respondents, 290 (90.6%) were from in-person recruitment (27.3% response rate) and 30 (9.4%) responses were from online recruitment. A total of 160/320 respondents (50.2%) had previously used cannabis, including smoking [140 (87.5%)], oils [69 (43.1%)] and edibles [92 (57.5%)]. The most common reasons for previous cannabis use were recreation [84/160 (52.5%)], pain alleviation [63/160 (39.4%)] and sleep enhancement [56/160 (35.0%)]. Only 33.8% of previous cannabis users thought their physicians were aware of their cannabis use. More than 50% of respondents probably would or definitely would try cannabis for symptom control for all 10 symptoms. Characteristics independently associated with interest in trying cannabis for symptom control included symptom type (pain, sleep, restless legs), online respondent {β = 0.7 [95% confidence interval (CI) 0.1–1.4]} and previous cannabis use [β = 1.2 (95% CI 0.9–1.5)].ConclusionsMany patients with kidney disease use cannabis and there is interest in trying cannabis for symptom control.
Cognitive Impairment 13 Months After Hospitalization for COVID-19
Authors: Stavem Knut , Einvik Gunnar , Lundqvist Christofer 
Published: July 2022

Abstract
This study assessed cognitive function 13 months after hospital discharge for coronavirus disease 2019 (COVID-19), using computer-based cognitive tests. Compared to population norms, 14%–25% of patients were impaired in each dimension, and 53% had cognitive impairment in 1 or more of 4 tests. There was some association with acute COVID-19 disease severity.
Lophomonas and Mycobacterium co-infection: the first molecular evidence to overcome potential diagnostic pitfalls
Authors: Taheri Amirmasoud , Fakhar Mahdi , Sharifpour Ali , Nakhaei Maryam , Banimostafavi Elham Sadat 
Published: July 2022

ABSTRACT
Lophomoniasis is an emerging protozoan disease that mostly involves the lungs. Because the disease has similar symptoms to other pulmonary infections such as tuberculosis, most cases are underdiagnosed. Here, we present a patient with co-infection of Lophomonas/Mycobacterium.
Intestinal evisceration and Staphylococcus aureus bacteremia due to ruptured umbilical hernia in a patient with liver cirrhosis: a case report and literature review
Authors: Iizuka Yuki , Hikone Mayu , Shimizu Yusuke , Tanabe Maki , Sugiyama Kazuhiro , Hamabe Yuichi 
Published: July 2022

ABSTRACT
Rupture of umbilical hernias is a potentially life-threatening condition that can occur in cirrhotic patients due to ascites. To the best of our knowledge, there are no previous reports on bacteremia following intestinal evisceration due to a ruptured umbilical hernia. Herein, we report a case of a 42-year-old female with a history of complicated alcoholic liver cirrhosis and schizophrenia who presented with intestinal evisceration and Staphylococcus aureus bacteremia secondary to a ruptured umbilical hernia. Due to a 2-day delay from presentation to hospitalization, the patient had a high risk for infection with skin flora. Initiation of appropriate antibiotic therapy, prompt surgical repair and adequate postoperative control of ascites markedly improved the patient’s condition. In cases of prolonged intestinal evisceration in adults with a ruptured umbilical hernia, bacteremia treatment with antibiotics coverage for skin flora should be considered.
The mycorrhiza-specific ammonium transporter ZmAMT3;1 mediates mycorrhiza-dependent nitrogen uptake in maize roots
Authors: Hui Jing , An Xia , Li Zhibo , Neuhäuser Benjamin , Ludewig Uwe , Wu Xuna , Schulze Waltraud X , Chen Fanjun , Feng Gu , Lambers Hans , Zhang Fusuo , Yuan Lixing 
Published: July 2022

Abstract
Most plant species can form symbioses with arbuscular mycorrhizal fungi (AMFs), which may enhance the host plant’s acquisition of soil nutrients. In contrast to phosphorus nutrition, the molecular mechanism of mycorrhizal nitrogen (N) uptake remains largely unknown, and its physiological relevance is unclear. Here, we identified a gene encoding an AMF-inducible ammonium transporter, ZmAMT3;1, in maize (Zea mays) roots. ZmAMT3;1 was specifically expressed in arbuscule-containing cortical cells and the encoded protein was localized at the peri-arbuscular membrane. Functional analysis in yeast and Xenopus oocytes indicated that ZmAMT3;1 mediated high-affinity ammonium transport, with the substrate NH4+ being accessed, but likely translocating uncharged NH3. Phosphorylation of ZmAMT3;1 at the C-terminus suppressed transport activity. Using ZmAMT3;1-RNAi transgenic maize lines grown in compartmented pot experiments, we demonstrated that substantial quantities of N were transferred from AMF to plants, and 68%–74% of this capacity was conferred by ZmAMT3;1. Under field conditions, the ZmAMT3;1-dependent mycorrhizal N pathway contributed &gt;30% of postsilking N uptake. Furthermore, AMFs downregulated ZmAMT1;1a and ZmAMT1;3 protein abundance and transport activities expressed in the root epidermis, suggesting a trade-off between mycorrhizal and direct root N-uptake pathways. Taken together, our results provide a comprehensive understanding of mycorrhiza-dependent N uptake in maize and present a promising approach to improve N-acquisition efficiency via plant–microbe interactions.
The role of cell-envelope synthesis for envelope growth and cytoplasmic density in Bacillus subtilis
Authors: Kitahara Yuki , Oldewurtel Enno R , Wilson Sean , Sun Yingjie , Altabe Silvia , de Mendoza Diego , Garner Ethan C , van Teeffelen Sven 
Published: July 2022

Abstract
All cells must increase their volumes in response to biomass growth to maintain intracellular mass density within physiologically permissive bounds. Here, we investigate the regulation of volume growth in the Gram-positive bacterium Bacillus subtilis. To increase volume, bacteria enzymatically expand their cell envelopes and insert new envelope material. First, we demonstrate that cell-volume growth is determined indirectly, by expanding their envelopes in proportion to mass growth, similarly to the Gram-negative Escherichia coli, despite their fundamentally different envelope structures. Next, we studied, which pathways might be responsible for robust surface-to-mass coupling: We found that both peptidoglycan synthesis and membrane synthesis are required for proper surface-to-mass coupling. However, surprisingly, neither pathway is solely rate-limiting, contrary to wide-spread belief, since envelope growth continues at a reduced rate upon complete inhibition of either process. To arrest cell-envelope growth completely, the simultaneous inhibition of both envelope-synthesis processes is required. Thus, we suggest that multiple envelope-synthesis pathways collectively confer an important aspect of volume regulation, the coordination between surface growth, and biomass growth.
Frataxin controls ketone body metabolism through regulation of OXCT1
Authors: Dong Yi NA , Mesaros Clementina , Xu Peining , Mercado-Ayón Elizabeth , Halawani Sarah , Ngaba Lucie Vanessa , Warren Nathan , Sleiman Patrick , Rodden Layne N , Schadt Kimberly A , Blair Ian A , Lynch David R 
Published: July 2022

Abstract
Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by the deficiency of mitochondrial protein frataxin, which plays a crucial role in iron–sulphur cluster formation and ATP production. The cellular function of frataxin is not entirely known. Here, we demonstrate that frataxin controls ketone body metabolism through regulation of 3-Oxoacid CoA-Transferase 1 (OXCT1), a rate limiting enzyme catalyzing the conversion of ketone bodies to acetoacetyl-CoA that is then fed into the Krebs cycle. Biochemical studies show a physical interaction between frataxin and OXCT1 both in vivo and in vitro. Frataxin overexpression also increases OXCT1 protein levels in human skin fibroblasts while frataxin deficiency decreases OXCT1 in multiple cell types including cerebellum and skeletal muscle both acutely and chronically, suggesting that frataxin directly regulates OXCT1. This regulation is mediated by frataxin-dependent suppression of ubiquitin–proteasome system (UPS)-dependent OXCT1 degradation. Concomitantly, plasma ketone bodies are significantly elevated in frataxin deficient knock-in/knockout (KIKO) mice with no change in the levels of other enzymes involved in ketone body production. In addition, ketone bodies fail to be metabolized to acetyl-CoA accompanied by increased succinyl-CoA in vitro in frataxin deficient cells, suggesting that ketone body elevation is caused by frataxin-dependent reduction of OXCT1 leading to deficits in tissue utilization of ketone bodies. Considering the potential role of metabolic abnormalities and deficiency of ATP production in FRDA, our results suggest a new role for frataxin in ketone body metabolism and also suggest modulation of OXCT1 may be a potential therapeutic approach for FRDA.
Simple semiclassical model of pressure-broadened infrared/microwave linewidths in the temperature range 200–3000 K
Authors: Buldyreva Jeanna , Yurchenko Sergei N , Tennyson Jonathan 
Published: July 2022

Abstract
There is a need for line-broadening parameters for molecules found in exoplanetary atmospheres for a variety of broadeners and a range of temperatures. The use of an easily handled semiclassical theoretical expression is suggested for the calculation of pressure-broadened linewidths for (vib)rotational transitions over a large temperature range (200–3000 K) starting from a minimal set of input parameters: kinetic molecular properties and the character of the leading term in the intermolecular interaction potential. Applications to NO and OH colliding with rare-gas atoms and non-polar molecules demonstrate good consistency with available measurements over the full temperature range indicated. The procedure therefore can be expected to provide realistic estimates for line broadening of ‘exotic’ molecules and molecular ions present in hot planetary atmospheres.
Ties of Possibility: Selecting Future Founders in Tokyo’s Start-up Ecosystem
Authors: FRENKENBERGER Bjol R 
Published: July 2022

Abstract
This article focuses on seed-stage start-up fundraising in the ‘village’ (mura), an assemblage of actors in Tokyo’s start-up scene characterised by first-time founders in their 20s or early 30s and their supporters. I analyse how efforts to secure funding unfold between founders and venture capitalists (VCs). Anthropological explorations of start-ups are rare, and my research is based on one of the first long-term fieldwork-based studies in a Japanese context. The material used in this article stems from 12 months of multi-sited fieldwork and 39 further semi-structured para-ethnographic interviews. Both founders and VCs stress the importance of embodied and affective pitch performances. Interlocutors invoke and describe such practices in-depth and separate them from ‘rational’ analysis. The overall focus on convincing performance seems to enforce particular founder role ideals that stress confident top–down communication styles rather than the negotiation of shortcomings or critical open discourse. This preference for confident top–down communication appears partly informed by the uncertainty within which start-ups and VCs act. The findings of this article suggest that seed-stage fundraising conventions in Tokyo reflect a preference for particular affective performance ideals, which extend beyond the economic analysis of the business case itself.
Exon-based Phylogenomics and the Relationships of African Cichlid Fishes: Tackling the Challenges of Reconstructing Phylogenies with Repeated Rapid Radiations
Authors: Astudillo-Clavijo Viviana , Stiassny Melanie L J , Ilves Katriina L , Musilova Zuzana , Salzburger Walter , López-Fernández Hernán 
Published: July 2022

AbstractAfrican cichlids (subfamily: Pseudocrenilabrinae) are among the most diverse vertebrates, and their propensity for repeated rapid radiation has made them a celebrated model system in evolutionary research. Nonetheless, despite numerous studies, phylogenetic uncertainty persists, and riverine lineages remain comparatively underrepresented in higher-level phylogenetic studies. Heterogeneous gene histories resulting from incomplete lineage sorting (ILS) and hybridization are likely sources of uncertainty, especially during episodes of rapid speciation. We investigate the relationships of Pseudocrenilabrinae and its close relatives while accounting for multiple sources of genetic discordance using species tree and hybrid network analyses with hundreds of single-copy exons. We improve sequence recovery for distant relatives, thereby extending the taxonomic reach of our probes, with a hybrid reference guided/de novo assembly approach. Our analyses provide robust hypotheses for most higher-level relationships and reveal widespread gene heterogeneity, including in riverine taxa. ILS and past hybridization are identified as the sources of genetic discordance in different lineages. Sampling of various Blenniiformes (formerly Ovalentaria) adds strong phylogenomic support for convict blennies (Pholidichthyidae) as sister to Cichlidae and points to other potentially useful protein-coding markers across the order. A reliable phylogeny with representatives from diverse environments will support ongoing taxonomic and comparative evolutionary research in the cichlid model system. [African cichlids; Blenniiformes; Gene tree heterogeneity; Hybrid assembly; Phylogenetic network; Pseudocrenilabrinae; Species tree.]
Payment strategies for behavioral health integration in hospital-affiliated and non-hospital-affiliated primary care practices
Authors: Ma Kris Pui Kwan , Mollis Brenda L , Rolfes Jennifer , Au Margaret , Crocker Abigail , Scholle Sarah H , Kessler Rodger , Baldwin Laura-Mae , Stephens Kari A 
Published: July 2022

Abstract
Recent value-based payment reforms in the U.S. called for empirical data on how primary care practices of varying characteristics fund their integrated behavioral health services. To describe payment strategies used by U.S. primary care practices to fund behavioral health integration and compare strategies between practices with and without hospital affiliation.Baseline data were used and collected from 44 practices participating in a cluster-randomized, pragmatic trial of behavioral health integration. Data included practice characteristics and payment strategies—fee-for-service payment, pay-for-performance incentives, grants, and graduate medical education funds. Descriptive and comparative analyses using Fisher’s exact tests and independent T-tests were conducted. The sample had 26 (59.1%) hospital-affiliated (hospital/health system-owned, academic medical centers and hospital-affiliated practices) and 18 (40.9%) non-hospital-affiliated practices (community health centers/federally qualified health centers and privately-owned practices). Most practices (88.6%) received payments through fee-for-service; 63.6% received pay-for-performance incentives; 31.8% received grant funds. Collaborative Care Management billing (CPT) codes were used in six (13.6%) practices. Over half (53.8%) of hospital-affiliated practices funded their behavioral health services through fee-for-service and pay-for-performance incentives only, as opposed to two-thirds (66.7%) of non-hospital-affiliated practices required additional support from grants and/or general medical education funds. Primary care practices support behavioral health integration through diverse payment strategies. More hospital-affiliated practices compared to non-hospital-affiliated practices funded integrated behavioral health services through fee-for-service and pay-for-performance incentives. Practices without hospital affiliation relied on multiple funding streams including grants and/or general medical education funds, suggesting their approach to financial sustainment may be more precarious or challenging, compared to hospital-affiliated practices.