bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paternalismo y control social. La caja de invalidez de Martín Montaner, industrial corchero (1900-1912).
Authors: ALVARADO Joaquim 
Published: May 2022

Presentación, análisis y objetivos de un proyecto desarrollado por el industrial corchero Martín Montaner Coris de un fondo de pensiones privado, financiado en su integridad por él mismo, para cubrir las necesidades económicas de sus obreros por enfermedad o retiro. El objetivo era evitar la intromisión de sindicatos ajenos a sus fábricas e intentar solucionar los problemas internamente, una solución que consideramos paternalista.
Palabras clave: Industria corchera, paternalismo, condiciones de vida obreras, pensiones, huelga
Mobiliario marmóreo en ámbito termal. El caso de las termas de "Aquinum".
Authors: CUADRA RUBIO Rocío 
Published: May 2022

Las excavaciones de las termas centrales de la antigua ciudad romana de Aquinum[1] han traído a la luz una serie de fragmentos de mármol identificados como pertenecientes a objetos decorativos y funcionales los cuales formaban parte del mobiliario escultórico de esta importante estructura. Hasta ahora los trabajos arqueológicos se han concentrado en el estudio sistemático de los muros, la identificación del uso de los ambientes y la delimitación del complejo, además ha interesado la búsqueda de los accesos a las termas. El complejo termal, dividido entre área masculina y área femenina, representa uno de los mayores en el territorio italiano y cuenta hasta hoy con un área de más de 9000m2.[2] El trabajo realizado sobre el mobiliario marmóreo[3] se ha concentrado en la búsqueda, la identificación y el estudio del mobiliario recuperado en los estratos de abandono de las termas. De este primer estudio el objetivo principal es el de comprender y completar, en la medida de lo posible, cuál era la disposición aproximada del mobiliario estudiado y de qué manera los visitantes han podido interactuar con estos objetos. A partir de este primer análisis hemos podido identificar diferentes bañeras o alvei, candelabros monumentales y una gran cantidad de objetos de pequeño formato. Cada uno de estos objetos se presenta en un primer catálogo que da protagonismo finalmente a esta tipología de hallazgos en las termas centrales de Aquinum.
Palabras clave: Aquinum, termas centrales, mobiliario marmóreo, escultura.
Coping with COVID-19: Differences in hope, resilience, and mental well-being across U.S. racial groups
Authors: Graham Carol , Chun Yung , Hamilton Bartram , Roll Stephen , Ross Wilbur , Grinstein-Weiss Michal 
Published: May 2022

Objectives
To explore if the COVID-19 pandemic revealed differences across racial groups in coping, resilience, and optimism, all of which have implications for health and mental well-being.

Methods
We collect data obtained from four rounds of a national sample of 5,000 US survey respondents in each round from April 2020 to February 2021. Using logistic regression and fixed effects models, we estimate the pandemic impacts on COVID-19 related concerns, social distancing behaviors, and mental health/life satisfaction and optimism for racial/income groups.

Results
Despite extreme income and health disparities before and during the COVID-19 outbreak, Blacks and Hispanics remain more resilient and optimistic than their White counterparts. Moreover, the greatest difference in resilience, optimism and better mental health—is found between poor Blacks and poor Whites, a difference that persists through all four rounds.

Conclusions
These deep differences in resilience have implications for the long-term mental health of different population groups in the face of an unprecedented pandemic. Better understanding these dynamics may provide lessons on how to preserve mental health in the face of public health and other large-scale crises.
The impact of the management strategies for patients with subclinical hypothyroidism on long-term clinical outcomes: An umbrella review
Authors: Bauer Brenda S. , Azcoaga-Lorenzo Amaya , Agrawal Utkarsh , Fagbamigbe Adeniyi Francis , McCowan Colin 
Published: May 2022

Aim
This umbrella review summarises and compares synthesised evidence on the impact of subclinical hypothyroidism and its management on long-term clinical outcomes.

Methods
We conducted comprehensive searches on MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Database of Systematic Reviews, JBI Evidence Synthesis, the PROSPERO register, Epistemonikos Database and PDQ Evidence from inception to February and July 2021 using keywords on subclinical hypothyroidism, treatment with levothyroxine, monitoring and primary outcomes (all-cause mortality, cardiovascular events, stroke, frailty fractures and quality of life). Only systematic reviews and meta-analyses on adult patient populations were considered. Study selection, data extraction and quality appraisal using AMSTAR-2 were done independently by two reviewers and discrepancies were resolved through discussion. Overlap across the selected reviews was also assessed, followed by a narrative synthesis of findings.

Results
A total of 763 studies were identified from literature searches; 20 reviews met inclusion criteria. Methodological quality ratings were high (n = 8), moderate (n = 7), and low (n = 5), but no reviews were excluded on this basis. Though there was slight overlap across all reviews, some pairwise comparisons had high corrected covered area scores. Compared to euthyroidism, untreated subclinical hypothyroidism was associated with a higher risk of cardiovascular events or death if Thyroid Stimulating Hormone was above 10mIU/L at baseline. Treatment was associated with a lower risk of death from all causes for patients younger than 70 years and possibly better cognitive and quality of life scores than untreated individuals. Evidence on the risk of strokes and fractures was inconclusive.

Conclusion
In the long term, treatment of subclinical hypothyroidism may be beneficial for some patient groups. However, the findings of this review are negatively impacted by the relative sparseness and poor quality of available evidence. Additional large and adequately powered studies are needed to investigate this topic further.

Systematic review registration
PROSPERO (CRD42021235172)
Pilot study evaluating everolimus molecular mechanisms in tuberous sclerosis complex and focal cortical dysplasia
Authors: Leitner Dominique F. , Kanshin Evgeny , Askenazi Manor , Siu Yik , Friedman Daniel , Devore Sasha , Jones Drew , Ueberheide Beatrix , Wisniewski Thomas , Devinsky Orrin 
Published: May 2022

Background
Tuberous sclerosis complex (TSC) and some focal cortical dysplasias (FCDs) are associated with dysfunctional mTOR signaling, resulting in increased cell growth and ribosomal S6 protein phosphorylation (phospho-S6). mTOR inhibitors can reduce TSC tumor growth and seizure frequency, and preclinical FCD studies indicate seizure suppression. This pilot study evaluated safety of mTOR inhibitor everolimus in treatment resistant (failure of >2 anti-seizure medications) TSC and FCD patients undergoing surgical resection and to assess mTOR signaling and molecular pathways.

Methods and findings
We evaluated everolimus in 14 treatment resistant epilepsy patients undergoing surgical resection (4.5 mg/m2 daily for 7 days; n = 4 Active, mean age 18.3 years, range 4–26; n = 10, Control, mean age 13.1, range 3–45). Everolimus was well tolerated. Mean plasma everolimus in Active participants were in target range (12.4 ng/ml). Brain phospho-S6 was similar in Active and Control participants with a lower trend in Active participants, with Ser235/236 1.19-fold (p = 0.67) and Ser240/244 1.15-fold lower (p = 0.66). Histologically, Ser235/236 was 1.56-fold (p = 0.37) and Ser240/244 was 5.55-fold lower (p = 0.22). Brain proteomics identified 11 proteins at <15% false discovery rate associated with coagulation system (p = 1.45x10-9) and acute phase response (p = 1.23x10-6) activation. A weighted gene correlation network analysis (WGCNA) of brain proteomics and phospho-S6 identified 5 significant modules. Higher phospho-S6 correlated negatively with cellular respiration and synaptic transmission and positively with organophosphate metabolic process, nuclear mRNA catabolic process, and neuron ensheathment. Brain metabolomics identified 14 increased features in Active participants, including N-acetylaspartylglutamic acid. Plasma proteomics and cytokine analyses revealed no differences.

Conclusions
Short-term everolimus before epilepsy surgery in TSC and FCD resulted in no adverse events and trending lower mTOR signaling (phospho-S6). Future studies should evaluate implications of our findings, including coagulation system activation and everolimus efficacy in FCD, in larger studies with long-term treatment to better understand molecular and clinical effects.

Clinical trials registration
ClinicalTrials.gov NCT02451696.
Evaluating the performance of the Pain Interference Index and the Short Form McGill Pain Questionnaire among Chilean injured working adults
Authors: Velez Juan Carlos , Friedman Lauren E. , Barbosa Clarita , Castillo Jessica , Juvinao-Quintero Diana L. , Williams Michelle A. , Gelaye Bizu 
Published: May 2022

Background
Chronic pain can lead to economic instability, decreased job productivity, and poor mental health. Therefore, reliable identification and quantification of chronic pain is important for clinical diagnosis and treatment.

Objective
To determine the psychometric properties of the Spanish language versions of the Pain Interference Index (PII) and the Short Form McGill Pain Questionnaire (SF-MPG) among a population of working adults who experienced injury in Santiago, Chile.

Methods
A total of 1,975 participants with work-related injuries were interviewed to collect sociodemographic, occupational, and chronic pain characteristics. Construct validity and factorial structure of the PII and SF-MPG were assessed through exploratory factor analyses (EFA). Cronbach’s alpha was used to evaluate internal consistency.

Results
The PII mean score was 3.84 ± 1.43 among all participants. The SF-MPG median score was 11 [IQR: 6–16] in this study population. Cronbach’s alpha for the PII was 0.90 and 0.87 for the SF-MP. EFA resulted in a one factor solution for the PII. A two-factor solution was found for the SF-MPG. The two-factors for SF-MPG were sensory and affective subscales with Cronbach’s alpha of 0.82 and 0.714, respectively. When the two scales were combined, an EFA analysis confirmed the PII and SF-MPG measure different aspects of chronic pain.

Conclusions
The PII and SF-MPG had good construct validity and reliability for assessing different aspects of chronic pain among working Chilean adults.
Association of hypertension with helicobacter pylori: A systematic review and meta‑analysis
Authors: Fang Yizhen , Xie Huabin , Fan Chunming 
Published: May 2022

Background and aims
The number of hypertensive population rises year by year recently, and their age becomes more youthful. For a long time, hypertension has long been regarded as a multi-factorial disease. In addition to smoking, genetics, diet and other factors, helicobacter pylori (H. pylori) had been regarded as a potential risk factor for hypertension in recent years. However, most studies had certain limitations and their results were inconsistent. Thus, it is necessary for us to assess the impact of H. pylori on hypertension through meta-analysis.

Methods
We searched all published relevant literature through multiple databases by July 23, 2021. Pooled results were calculated under the random effect model. Heterogeneity was evaluated by the Q statistic and the I2 statistic. The risk of bias was evaluated via ROBINS-I tool. Publication bias was evaluated by the Egger test and Begg funnel plot.

Results
6 eligible studies involving 11317 hypertensive patients and 12765 controls were selected from 20767 retrieval records. Our research confirmed that H. pylori significantly increased the probability of suffering from hypertension in the random effect model (OR:1.34, 95% CI:1.10–1.63, P = 0.002, I2 = 74%). The same results were also found in both Asian population and developing country (OR:1.28, 95%CI:1.05–1.55, P = 0.003, I2 = 78.5%).

Conclusions
Our results confirmed that H. pylori was a vital risk factor for hypertension. H. pylori-infected people were 13.4% higher risk for hypertension than uninfected individuals. In addition, it will be a new method to prevent and treat hypertension by eradicating H. pylori.

Trial registration
The registration number for systematic review in PROSPERO CRD42021279677.
Perturbation-based trunk stabilization training in elite rowers: A pilot study
Authors: Schäfer Robin , Schäfer Hendrik , Platen Petra 
Published: May 2022

Introduction
Low back pain is a major health issue in elite rowers. High training volume, frequent flexion movements of the lower spine and rotational movement in sweep rowing contribute to increased spinal strain and neuropathological patterns. Perturbation-based trunk stabilization training (PTT) may be effective to treat neuromuscular deficits and low back pain.

Methods
All boat classes (8+, 4+/-, 2-) of the male German national sweep rowing team participated in this non-randomized parallel group study. We included 26 athletes (PTT: n = 12, control group: n = 14) in our analysis. Physical and Sports therapists conducted 16 individualized PTT sessions á 30–40 minutes in 10 weeks, while the control group kept the usual routines. We collected data before and after intervention on back pain intensity and disability, maximum isometric trunk extension and flexion, jump height and postural sway of single-leg stance.

Results
We found less disability (5.3 points, 95% CI [0.4, 10.1], g = 0.42) for PTT compared to control. Pain intensity decreased similar in both groups (-14.4 and -15.4 points), yielding an inconclusive between-group effect (95% CI [-16.3, 14.3]). Postural sway, strength and jump height tend to have no between- and within-group effects.

Conclusion
Perturbation-based trunk stabilization training is possibly effective to improve the physical function of the lower back in elite rowers.
Prevalence, incidence, morbidity and mortality rates of COPD in Saudi Arabia: Trends in burden of COPD from 1990 to 2019
Authors: Alqahtani Jaber S. 
Published: May 2022

Background
The available data to determine the chronic obstructive pulmonary disease (COPD) burden in Saudi Arabia are scarce. Therefore, this study closely examines and tracks the trends of the COPD burden in Saudi Arabia from 1990 to 2019 using the dataset of the Global Burden of Disease (GBD) 2019.

Methods
This study used the GBD 2019 dataset to analyse the COPD prevalence, incidence, morbidity and mortality rates in the Saudi Arabian population from 1990 to 2019, stratified by sex and age. The age-standardised rate was used to determine the prevalence, incidence, years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life years (DALYs) and deaths.

Results
In 2019, an estimated 434,560.64 people (95% Uncertainty Interval (UI) 396,011.72–473,596.71) had COPD in Saudi Arabia, corresponding to an increase of 329.82% compared with the number of diagnosed people in 1990 [101,104.05 (95% UI 91,334.4–111,223.91)]. The prevalence rate of COPD increased by 49%, from 1,381.26 (1,285.35–1,484.96) cases per 100,000 in 1990 to 2,053.04 (1918.06–2194.29) cases per 100,000 in 2019, and this trend was higher in males than females. The incidence rate of COPD in 2019 was 145.06 (136.62–154.76) new cases per 100,000, representing an increase of 43.4% from the 1990 incidence rate [101.18 (95.27–107.86)]. In 2019, the DALYs rate was 508.15 (95% UI 434.85–581.58) per 100,000 population. This was higher in males than females, with a 14.12% increase among males. In 2019, YLLs contributed to 63.6% of DALYs due to COPD. The death rate due to COPD was 19.6 (95% UI 15.94–23.39) deaths per 100 000 in 2019, indicating a decrease of 41.44% compared with the death rate in 1990 [33.55 deaths per 100 000 (95% UI 25.13–47.69)]. In 2019, COPD deaths accounted for 1.65% (1.39–1.88) of the total of deaths in Saudi Arabia and 57% of all deaths caused by chronic respiratory diseases.

Conclusion
Over the period 1990–2019, the prevalence and incidence of COPD in Saudi Arabia have been steadily rising. Even though COPD morbidity and death rates have been decreasing, they remain higher in men and older age. The holistic assessment and interventions with careful attention to optimising the community-based primary care management, such as screening for early diagnosis, smoking cessation programs and pulmonary rehabilitation, are likely to be the most successful strategies to reduce the burden of COPD in Saudi Arabia.
Urea(lly) Got Me: An Uncommon Etiology of Peripartum Liver Failure
Authors: Spiller Robert E. , Colombo Christopher J. , Lindholm Phillip C. , Kwon James 
Published: May 2022

ABSTRACT
A 23-year-old woman presented 4 days postpartum for agitation and confusion, with initial evaluation consistent with acute fatty liver of pregnancy (AFLP). Later in her course, an amino acid panel was highly suggestive of citrullinemia type 1. She was started on arginine supplementation and glycerol phenylbutyrate and evaluated for a liver transplant. After starting the medication and diet modification, her liver failure resolved, and she was safely discharged. Urea cycle disorders may mimic AFLP with liver enzyme elevation, delirium, and hyperammonemia, but unlike AFLP, patients with urea cycle disorders will typically not recover without dietary modifications and/or medication.
Gravity and lymphodynamics
Authors: Holm‐Weber Thomas , Kristensen Rasmus Eskild , Mohanakumar Sheyanth , Hjortdal Vibeke E. 
Published: May 2022

AbstractThe lymphatic system is compromised in different groups of patients. To recognize pathology, we must know what is healthy. We use Near‐Infrared Fluorescence (NIRF) to assess peripheral lymphatic function in humans. We have shown that external factors such as exercise, hyperthermia, and pharmacological mediators influence the function of peripheral lymphatic vessels. In this study, we explored the impact on lymphatic vessels by the ever‐present external factor—gravity. We used NIRF imaging to investigate the lymphatic changes to gravity. Gravity was assessed by changing body position from supine to standing. We extracted following lymphatic functional parameters: lymphatic packet propulsion frequency (contractions/min), velocity (cm/s), and pressure (mmHg). Raw data analysis was performed using a custom‐written Labview program. All sequences were analyzed by two observers and interclass correlation scores were calculated. All statistical analysis was performed using RStudio Team (2021). RStudio: Integrated Development Environment for R. RStudio, PBC. Healthy participants (n = 17, 11 males, age 28.1 ± 2.6 years) were included. The lymphatic packet propulsion frequency at baseline was 0.5 ± 0.2 contractions/min and rose within 3 min significantly to a maximum of 1.2 ± 0.5 contractions/min during upright posture and remained significantly higher than the baseline lymphatic packet propulsion frequency after lying down again for up to 6 min. The lymph velocity was 1.5 ± 0.4 cm/s at baseline and changed in both directions and without a specific pattern at different points in time during standing. Lymph pressure was significantly higher while standing (mean increase 9 mmHg, CI: 2–15 mmHg). The ICC scores were 89.8% (85.9%–92.7%), 59.3% (46.6%–69.6%) and 89.4% (79.0%–94.8%) in lymphatic packet propulsion frequency (130 observations), velocity (125 observations), and pressure (30 observations), respectively. The lymphatic system responds within few minutes to gravitational changes by increasing lymphatic packet propulsion frequency and pressure.
The Effects of School Start Time on Educational Outcomes: Evidence from the 9 O’clock Attendance Policy in South Korea
Authors: Kim Taehoon 
Published: May 2022

Abstract
This study estimates the effects of school start time on sleep time, time use, and educational achievement of high school students. Gyeonggi province, the largest province in South Korea, has implemented the 9 O’clock Attendance Policy, which has delayed school start times to 9:00 AM since September 2014. Changes in the above outcomes before and after the policy implementation are compared between Gyeonggi and other provinces which do not implement the policy. The difference-in-differences estimation results show that the policy increases sleep time, and this is mainly from delayed wake-up time. The policy also reduces adolescents’ time use for computer games. The estimation results using administrative national exam data show that the 9 O’clock Attendance Policy does not significantly affect academic achievement.
Corrosion, stress corrosion cracking and corrosion fatigue behavior of magnesium alloy bioimplants
Authors: Das Priyabrata , Kumar T. S. Sampath , Sahu Kisor K. , Gollapudi Srikant 
Published: May 2022

Abstract
The use of magnesium and its alloys as temporary implants has gained interest in the last two decades due to their good mechanical properties and bio-degradability in the in-vivo conditions. However, the issues of higher corrosion rate and stress corrosion cracking persist, which are responsible for the implants’ early failure. This review paper focuses on the challenges involved in the use of magnesium-based implants and the advancements in mitigating the corrosion-related issues for in-vivo use of biodegradable magnesium alloy implants. Herein we review the degradation behavior of three groups of magnesium alloys, i.e., aluminum-containing Mg alloy, rare earth element (REE) containing Mg alloy, and aluminum-free Mg alloy in a variety of testing media. We also review various surface modification techniques such as mechanical methods, physical methods, and chemical methods adopted to address the shortcomings of the Mg alloys. Furthermore, recent developments in Mg based bioimplants such as Mg-based open porous scaffolds, nanostructured Mg alloys and Mg based bulk metallic glasses are reviewed. In the end, recent clinical trials of the Mg-based implant were reported in detail.
Comparative study of estimating the Curie point depth and heat flow using potential magnetic data
Authors: Ibrahim Amin , Saada Saada Ahmed , Mickus Kevin , Abdelrahman Kamal , Khedr Fares Ibrahim 
Published: May 2022

Abstract
The estimation of the Curie point depth (CPD) and heat flow (HF) from magnetic data is useful for geothermal and tectonic studies. However, the methodology of estimating these values is still controversial as numerous studies have used different types of transformed magnetic data. Most studies utilize the total magnetic intensity (TMI) or the reduced to the pole (RTP) data, and since shallow magnetic bodies may affect the final CPD values, low-pass (LP) wavelength filtering has also been used to estimate the CPD. In this study, the two-dimensional radially averaged spectral analysis was applied to the land-based magnetic data from the Sinai Peninsula. TMI and RTP data were both analyzed, using different LP filtered wavelengths, and the final CPD and HF values were compared. The cut-off wavelength parameter was selected in terms of the geologic complexity. The results show that the estimated CPD values are well correlated regardless of whether the magnetic data were either TMI or RTP. The RTP data produced a spatial shift in the CPD smaller than the window size being used. Additionally, the centroid method is primarily dependent on the wavenumber, which varied slightly on applying the RTP. There were slight differences in the estimated CPDs when a short LP filter (e.g., 20 km) was applied, whereas increasing the wavelength (e.g., 40 km) caused the CPD values to increase exceeding the plausible depth limits, and the associated spatial trends varied when compared to the other methods. In areas where the basement rocks were shallow or exposed, a LP filter can be applied with short cut-off wavelength. The estimated CPDs were discussed in the context of seismicity data, gravity-based Moho depths, and HF measurements.