bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary diversity and depression: cross-sectional and longitudinal analyses in Spanish adult population with metabolic syndrome. Findings from PREDIMED-Plus trial
Authors: Cano-Ibáñez Naomi , Serra-Majem Lluis , Martín-Peláez Sandra , Martínez-González Miguel Ángel , Salas-Salvadó Jordi , Corella Dolores , Lassale Camille , Martínez Jose Alfredo , Alonso-Gómez Ángel M , Wärnberg Julia , Vioque Jesús , Romaguera Dora , López-Miranda José , Estruch Ramon , Gómez-Pérez Ana María , Lapetra José , Fernández-Aranda Fernando , Bueno-Cavanillas Aurora , Tur Josep A , Cubelos Naiara , Pintó Xavier , Gaforio José Juan , Matía-Martín Pilar , Vidal Josep , Calderón Cristina , Daimiel Lidia , Ros Emilio , Gea Alfredo , Babio Nancy , Gimenez-Alba Ignacio Manuel , Zomeño-Fajardo María Dolores , Abete Itziar , Tojal Sierra Lucas , Romero-Galisteo Rita P , García de la Hera Manoli , Martín-Padillo Marian , García-Ríos Antonio , Casas Rosa M , Fernández-García JC , Santos-Lozano José Manuel , Toledo Estefanía , Becerra-Tomas Nerea , Sorli Jose V , Schröder Helmut , Zulet María A , Sorto-Sánchez Carolina , Diez-Espino Javier , Gómez-Martínez Carlos , Fitó Montse , Sánchez-Villegas Almudena 
Published: July 2022

AbstractObjective:To examine the cross-sectional and longitudinal (2-year follow-up) associations between dietary diversity (DD) and depressive symptoms.Design:An energy-adjusted dietary diversity score (DDS) was assessed using a validated FFQ and was categorised into quartiles (Q). The variety in each food group was classified into four categories of diversity (C). Depressive symptoms were assessed with Beck Depression Inventory-II (Beck II) questionnaire and depression cases defined as physician-diagnosed or Beck II >= 18. Linear and logistic regression models were used.Setting:Spanish older adults with metabolic syndrome (MetS).Participants:A total of 6625 adults aged 55–75 years from the PREDIMED-Plus study with overweight or obesity and MetS.Results:Total DDS was inversely and statistically significantly associated with depression in the cross-sectional analysis conducted; OR Q4v. Q1 = 0·76 (95 % CI (0·64, 0·90)). This was driven by high diversity compared to low diversity (C3v. C1) of vegetables (OR = 0·75, 95 % CI (0·57, 0·93)), cereals (OR = 0·72 (95 % CI (0·56, 0·94)) and proteins (OR = 0·27, 95 % CI (0·11, 0·62)). In the longitudinal analysis, there was no significant association between the baseline DDS and changes in depressive symptoms after 2 years of follow-up, except for DD in vegetables C4v. C1 = (β= 0·70, 95 % CI (0·05, 1·35)).Conclusions:According to our results, DD is inversely associated with depressive symptoms, but eating more diverse does not seem to reduce the risk of future depression. Additional longitudinal studies (with longer follow-up) are needed to confirm these findings.
CUSRA2021: A Radially Anisotropic Model of the Contiguous US and Surrounding Regions by Full‐Waveform Inversion
Authors: Zhou Tong , Li Jiaqi , Xi Ziyi , Li Guoliang , Chen Min 
Published: July 2022

AbstractThe lithospheric structure of the contiguous US and surrounding regions offers clues into the tectonic history, including interactions between subducting slabs and cratons. In this paper, we present a new radially anisotropic shear wave speed model of the upper mantle (70–410 km) of the contiguous US and surrounding regions, constrained by seismic full‐waveform inversion. The new model (named CUSRA2021) utilizes frequency‐dependent travel time measurements, from 160 earthquake events recorded by 5,280 stations. The data coverage in eastern US is improved by incorporating more intraplate earthquakes. The final model exhibits clear and detailed shear wave speed anomalies correlating well with tectonic units such as North America Craton (high‐Vs), Cascadia subduction zones (high‐Vs), Columbia Plateau (low‐Vs), Basin and Range (low‐Vs), etc. In particular, the detailed structure of the North America Craton beneath Illinois basin is revealed. The depth of high‐Vs anomaly beneath the North America Craton correlates well with S‐to‐P receiver function and SH reflection results. Besides, the radial anisotropy in the Craton lithosphere shows a layering structure, which may relate to the process of lithospheric accretion and the origin of mid‐lithosphere discontinuities.
Why Do CMIP6 Models Fail to Simulate Snow Depth in Terms of Temporal Change and High Mountain Snow of China Skillfully?
Authors: Zhang Hongbo , Zhang Fan , Zhang Guoqing , Yan Wei 
Published: July 2022

AbstractGlobal climate models are important tools for investigating historical and future responses of snow under climate change. However, snow simulations from Coupled Model Intercomparison Project Phase 6 (CMIP6) models have not been well evaluated in terms of temporal change and mountain snow, with major error sources remaining unclear. This study synthetically uses long‐term station observations, reanalysis, and remote sensing data to evaluate snow depth simulations of 31 state‐of‐the‐art CMIP6 models in both the high mountain Tibetan Plateau and other areas of China, and analyzes the sources of error. For the first‐time, the accumulated errors of precipitation and temperature of prior months are found to be crucial for explaining why CMIP6 models failed to capture trends and hotspots of snow depth change and notable time lags of the peak month. The worst snow depth performance of CMIP6 was on the Tibetan Plateau and resulted from more serious precipitation overestimates and temperature underestimates than in other regions.
The Global Surface Area Variations of Lakes and Reservoirs as Seen From Satellite Remote Sensing
Authors: Bonnema Matthew , David Cédric H. , Frasson Renato Prata de Moraes , Oaida Catalina , Yun Sang‐Ho 
Published: July 2022

AbstractNatural lakes and artificial reservoirs are important components of the Earth system and essential for freshwater, food, and energy. Relatively little is known about the variations of lake and reservoir surface area globally. For the first time, this study presents the global variation of lake and reservoir surface areas for all water bodies larger than 1 km2. Using radar remote sensing, we found that global aggregate area variations were only 2% of total surface area over a 3 year period. When considering the total surface area of shoreline regions that transition between land and water, these variations equaled 20% of total lake and reservoir surface area, largely driven by variations of smaller water bodies. Additionally, surface areas of reservoirs tends to be more variable than the surface area of lakes of similar size. The large surface area variations evidenced here, could have a previously underappreciated impact on the Earth System.
A Terrestrial Gamma‐Ray Flash From the 2022 Hunga Tonga–Hunga Ha'apai Volcanic Eruption
Authors: Briggs M. S. , Lesage S. , Schultz C. , Mailyan B. , Holzworth R. H. 
Published: July 2022

AbstractThe Hunga Tonga–Hunga Ha'apai submarine volcano recently resumed activity. Violent eruptions on 14th and 15th January 2022 launched a tall ash plume that produced extremely high lightning rates. Here we report a terrestrial gamma‐ray flash (TGF) that was produced by the volcanic lightning and observed from space by the Fermi Gamma‐ray Burst Monitor (GBM). Observations by radio lightning networks and especially by the Geostationary Lightning Mapper show that the only lightning close enough to produce a TGF detectable by Fermi GBM was from the volcano's plume. With the observing duration of Fermi, observing a single TGF is consistent with the hypothesis that the volcanic lightning of this eruption produced TGFs at the average rate of thunderstorm lightning. The observation of a strong TGF from space also indicates that the electric field was oriented so as to accelerate electrons upward.
PTHrP promotes subchondral bone formation in TMJ-OA
Authors: Zhang Jun , Pi Caixia , Cui Chen , Zhou Yang , Liu Bo , Liu Juan , Xu Xin , Zhou Xuedong , Zheng Liwei 
Published: July 2022

AbstractPTH-related peptide (PTHrP) improves the bone marrow micro-environment to activate the bone-remodelling, but the coordinated regulation of PTHrP and transforming growth factor-β (TGFβ) signalling in TMJ-OA remains incompletely understood. We used disordered occlusion to establish model animals that recapitulate the ordinary clinical aetiology of TMJ-OA. Immunohistochemical and histological analyses revealed condylar fibrocartilage degeneration in model animals following disordered occlusion. TMJ-OA model animals administered intermittent PTHrP (iPTH) exhibited significantly decreased condylar cartilage degeneration. Micro-CT, histomorphometry, and Western Blot analyses disclosed that iPTH promoted subchondral bone formation in the TMJ-OA model animals. In addition, iPTH increased the number of osterix (OSX)-positive cells and osteocalcin (OCN)-positive cells in the subchondral bone marrow cavity. However, the number of osteoclasts was also increased by iPTH, indicating that subchondral bone volume increase was mainly due to the iPTH-mediated increase in the bone-formation ability of condylar subchondral bone. In vitro, PTHrP treatment increased condylar subchondral bone marrow-derived mesenchymal stem cell (SMSC) osteoblastic differentiation potential and upregulated the gene and protein expression of key regulators of osteogenesis. Furthermore, we found that PTHrP-PTH1R signalling inhibits TGFβ signalling during osteoblastic differentiation. Collectively, these data suggested that iPTH improves OA lesions by enhancing osteoblastic differentiation in subchondral bone and suppressing aberrant active TGFβ signalling. These findings indicated that PTHrP, which targets the TGFβ signalling pathway, may be an effective biological reagent to prevent and treat TMJ-OA in the clinic.
Modular micro-PCR system for the onsite rapid diagnosis of COVID-19
Authors: Nguyen Phuong Quoc Mai , Wang Ming , Ann Maria Nelisha , Li Adelicia Yongling , Tan Hsih Yin , Xiong Gordon Minru , Tan Meng-Kwang Marcus , Bhagat Ali Asgar S. , Ong Catherine W. M. , Lim Chwee Teck 
Published: July 2022

AbstractEffective containment of the COVID-19 pandemic requires rapid and accurate detection of the pathogen. Polymerase chain reaction (PCR) remains the gold standard for COVID-19 confirmation. In this article, we report the performance of a cost-effective modular microfluidic reverse transcription (RT)-PCR and RT-loop mediated isothermal amplification (RT-LAMP) platform, Epidax®, for the point-of-care testing and confirmation of SARS-CoV-2. This platform is versatile and can be reconfigured either for screening using endpoint RT-PCR or RT-LAMP tests or for confirmatory tests using real-time RT-PCR. Epidax® is highly sensitive and detects as little as 1 RNA copy per µL for real-time and endpoint RT-PCR, while using only half of the reagents. We achieved comparable results with those of a commercial platform when detecting SARS-CoV-2 viruses from 81 clinical RNA extracts. Epidax® can also detect SARS-CoV-2 from 44 nasopharyngeal samples without RNA extraction by using a direct RT-PCR assay, which shortens the sample-to-answer time to an hour with minimal user steps. Furthermore, we validated the technology using an RT-LAMP assay on 54 clinical RNA extracts. Overall, our platform provides a sensitive, cost-effective, and accurate diagnostic solution for low-resource settings.
Overexposure to COVID-19 information amplifies emotional distress: a latent moderated mediation model
Authors: Feng Yi , Gu Wen , Dong Fangbai , Dong Dan , Qiao Zhihong 
Published: July 2022

AbstractAn infodemic has accompanied the COVID-19 pandemic. This study explores whether overexposure to COVID-19-related information amplifies emotional distress. A cross-sectional online survey was conducted in China during the outbreak and after the peak of the pandemic (N = 1313). A latent moderated mediation model was built to analyze this relationship. COVID-19 information exposure was found to relate positively with emotional distress, and risk perception mediated the association between them. Additionally, psychological resilience moderated the mediating effects of risk perception. However, five factors of resilience differed in their moderating effects. This study offers theoretical and practical implications apropos clinical intervention and public health management.
Cytochrome B5 type A alleviates HCC metastasis via regulating STOML2 related autophagy and promoting sensitivity to ruxolitinib
Authors: Guo Hongrui , Liang Shuhang , Wang Yan , Zhou Shuo , Yin Dalong , Zhang Shugeng , Wang Jizhou , Wu Dehai , Ma Kun , Liu Yufeng , Sun Linmao , Ji Changyong , Li Xianying , Zhou Huanran , Yang Guangchao , Guo Xinyu , Cui Tianming , Li Zihao , Liu Yao , Wang Jiabei , Liu Lianxin 
Published: July 2022

AbstractThe incidence of hepatocellular carcinoma (HCC) is increasing in the world. However, its role and underlying molecular mechanism in HCC progression remain unclear. We found that CYB5A plays a key role in HCC metastasis by inhibiting the JAK1/STAT3 pathway through binding to STOML2. CYB5A combined with STOML2 can predict the outcome of patients. To demonstrate the effect of CYB5A on JAK1 inhibitor function, we applied Ruxolitinib in metastatic tumors with high CYB5A expression and found that it slowed disease progression and prolonged survival in mice. To the best of our knowledge, this study is the first to report the Ruxolitinib effect on the metastatic ability of HCC cells in vivo and in vitro.
Periosteal stem cells control growth plate stem cells during postnatal skeletal growth
Authors: Tsukasaki Masayuki , Komatsu Noriko , Negishi-Koga Takako , Huynh Nam Cong-Nhat , Muro Ryunosuke , Ando Yutaro , Seki Yuka , Terashima Asuka , Pluemsakunthai Warunee , Nitta Takeshi , Nakamura Takashi , Nakashima Tomoki , Ohba Shinsuke , Akiyama Haruhiko , Okamoto Kazuo , Baron Roland , Takayanagi Hiroshi 
Published: July 2022

AbstractThe ontogeny and fate of stem cells have been extensively investigated by lineage-tracing approaches. At distinct anatomical sites, bone tissue harbors multiple types of skeletal stem cells, which may independently supply osteogenic cells in a site-specific manner. Periosteal stem cells (PSCs) and growth plate resting zone stem cells (RZSCs) critically contribute to intramembranous and endochondral bone formation, respectively. However, it remains unclear whether there is functional crosstalk between these two types of skeletal stem cells. Here we show PSCs are not only required for intramembranous bone formation, but also for the growth plate maintenance and prolonged longitudinal bone growth. Mice deficient in PSCs display progressive defects in intramembranous and endochondral bone formation, the latter of which is caused by a deficiency in PSC-derived Indian hedgehog (Ihh). PSC-specific deletion of Ihh impairs the maintenance of the RZSCs, leading to a severe defect in endochondral bone formation in postnatal life. Thus, crosstalk between periosteal and growth plate stem cells is essential for post-developmental skeletal growth.
Pinhole-seeded lateral epitaxy and exfoliation of GaSb films on graphene-terminated surfaces
Authors: Manzo Sebastian , Strohbeen Patrick J. , Lim Zheng Hui , Saraswat Vivek , Du Dongxue , Xu Shining , Pokharel Nikhil , Mawst Luke J. , Arnold Michael S. , Kawasaki Jason K. 
Published: July 2022

AbstractRemote epitaxy is a promising approach for synthesizing exfoliatable crystalline membranes and enabling epitaxy of materials with large lattice mismatch. However, the atomic scale mechanisms for remote epitaxy remain unclear. Here we experimentally demonstrate that GaSb films grow on graphene-terminated GaSb (001) via a seeded lateral epitaxy mechanism, in which pinhole defects in the graphene serve as selective nucleation sites, followed by lateral epitaxy and coalescence into a continuous film. Remote interactions are not necessary in order to explain the growth. Importantly, the small size of the pinholes permits exfoliation of continuous, free-standing GaSb membranes. Due to the chemical similarity between GaSb and other III-V materials, we anticipate this mechanism to apply more generally to other materials. By combining molecular beam epitaxy with in-situ electron diffraction and photoemission, plus ex-situ atomic force microscopy and Raman spectroscopy, we track the graphene defect generation and GaSb growth evolution a few monolayers at a time. Our results show that the controlled introduction of nanoscale openings in graphene provides an alternative route towards tuning the growth and properties of 3D epitaxial films and membranes on 2D material masks.
Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells
Authors: Igarashi Nanase , Miyata Kenichi , Loo Tze Mun , Chiba Masatomo , Hanyu Aki , Nishio Mika , Kawasaki Hiroko , Zheng Hao , Toyokuni Shinya , Kon Shunsuke , Moriyama Keiji , Fujita Yasuyuki , Takahashi Akiko 
Published: July 2022

AbstractCellular senescence and cell competition are important tumor suppression mechanisms that restrain cells with oncogenic mutations at the initial stage of cancer development. However, the link between cellular senescence and cell competition remains unclear. Senescent cells accumulated during the in vivo aging process contribute toward age-related cancers via the development of senescence-associated secretory phenotype (SASP). Here, we report that hepatocyte growth factor (HGF), a SASP factor, inhibits apical extrusion and promotes basal protrusion of Ras-mutated cells in the cell competition assay. Additionally, cellular senescence induced by a high-fat diet promotes the survival of cells with oncogenic mutations, whereas crizotinib, an inhibitor of HGF signaling, provokes the removal of mutated cells from mouse livers and intestines. Our study provides evidence that cellular senescence inhibits cell competition-mediated elimination of oncogenic cells through HGF signaling, suggesting that it may lead to cancer incidence during aging.
Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues
Authors: Song Qi , Yang Ye , Jiang Dongxian , Qin Zhaoyu , Xu Chen , Wang Haixing , Huang Jie , Chen Lingli , Luo Rongkui , Zhang Xiaolei , Huang Yufeng , Xu Lei , Yu Zixiang , Tan Subei , Deng Minying , Xue Ruqun , Qie Jingbo , Li Kai , Yin Yanan , Yue Xuetong , Sun Xiaogang , Su Jieakesu , He Fuchu , Ding Chen , Hou Yingyong 
Published: July 2022

AbstractSquamous cell carcinoma (SCC) and adenocarcinoma (AC) are two main histological subtypes of solid cancer; however, SCCs are derived from different organs with similar morphologies, and it is challenging to distinguish the origin of metastatic SCCs. Here we report a deep proteomic analysis of 333 SCCs of 17 organs and 69 ACs of 7 organs. Proteomic comparison between SCCs and ACs identifies distinguishable pivotal pathways and molecules in those pathways play consistent adverse or opposite prognostic roles in ACs and SCCs. A comparison between common and rare SCCs highlights lipid metabolism may reinforce the malignancy of rare SCCs. Proteomic clusters reveal anatomical features, and kinase-transcription factor networks indicate differential SCC characteristics, while immune subtyping reveals diverse tumor microenvironments across and within diagnoses and identified potential druggable targets. Furthermore, tumor-specific proteins provide candidates with differentially diagnostic values. This proteomics architecture represents a public resource for researchers seeking a better understanding of SCCs and ACs.
Milli-scale cellular robots that can reconfigure morphologies and behaviors simultaneously
Authors: Yang Xiong , Tan Rong , Lu Haojian , Fukuda Toshio , Shen Yajing 
Published: July 2022

AbstractModular robot that can reconfigure architectures and functions has advantages in unpredicted environment and task. However, the construction of modular robot at small-scale remains a challenge since the lack of reliable docking and detaching strategies. Here we report the concept of milli-scale cellular robot (mCEBOT) achieved by the heterogeneous assembly of two types of units (short and long units). Under the magnetic field, the proposed mCEBOT units can not only selectively assemble (e.g., end-by-end and side-by-side) into diverse morphologies corresponding to the unstructured environments, but also configure multi-modes motion behaviors (e.g., slipping, rolling, walking and climbing) based on the on-site task requirements. We demonstrate its adaptive mobility from narrow space to high barrier to wetting surface, and its potential applications in hanging target taking and environment exploration. The concept of mCEBOT offers new opportunities for robot design, and will broaden the field of modular robot in both miniaturization and functionalization.
Deep learning-enabled real-time personal handwriting electronic skin with dynamic thermoregulating ability
Authors: Xiang Shengxin , Tang Jiafeng , Yang Lei , Guo Yanjie , Zhao Zhibin , Zhang Weiqiang 
Published: July 2022

AbstractThe rapid rise of the Internet of things (IoT) have brought the progress of electronic skin (e-skin). E-skin is used to imitate or even surpass the functions of human skin. Thermoregulating is one of the crucial functions of human skin, it is significant to develop a universal way to realize e-skin thermoregulating. Here, inspired by the sweat gland structure in human skin, we report a simple method for achieving dynamic thermoregulating, attributing to the temperature of microencapsulated paraffin remains unchanged when phase change occurs. Combining with the principle of triboelectric nanogenerator, a deep learning model is employed to recognize the output signals of handwriting different letters on ME-skin, and the recognition accuracy reaches 98.13%. Finally, real-time recognition and display of handwritings are successfully implemented by the ME-skin, which provides a general solution for thermoregulating e-skin and application direction for e-skin in the field of IoT.
Three years of hourly data from 3021 smart heat meters installed in Danish residential buildings
Authors: Schaffer Markus , Tvedebrink Torben , Marszal-Pomianowska Anna 
Published: July 2022

AbstractThe now widespread use of smart heat meters for buildings connected to district heating networks generates data at an unknown extent and temporal resolution. This data encompasses information that enables new data-driven approaches in the building sector. Real-life data of sufficient size and quality are necessary to facilitate the development of such methods, as subsequent analyses typically require a complete equidistant dataset without missing or erroneous values. Thus, this work presents three years (2018-01-03 till 2020-12-31) of screened, interpolated, and imputed data from 3,021 commercial smart heat meters installed in Danish residential buildings. The screening aimed to detect data from not used meters, resolve issues caused by the data storage process and identify erroneous values. Linear interpolation was used to obtain equidistant data. After the screening, 0.3% of the data were missing, which were imputed using a weighted moving average based on a systematic comparison of nine different imputation methods. The original and processed data are published together with the code for data processing (https://doi.org/10.5281/zenodo.6563114).