bluuebunny/crossref_metadata_2025_split huggingface dataset:
External Surface Water Influence on Explosive Eruption Dynamics, With Implications for Stratospheric Sulfur Delivery and Volcano-Climate Feedback
Authors: Rowell Colin R. , Jellinek A. Mark , Hajimirza Sahand , Aubry Thomas J. 
Published: April 2022

Explosive volcanic eruptions can inject sulfur dioxide (SO2) into the stratosphere to form aerosol particles that modify Earth’s radiation balance and drive surface cooling. Eruptions involving interactions with shallow layers (≤500 m) of surface water and ice modify the eruption dynamics that govern the delivery of SO2 to the stratosphere. External surface water controls the evolution of explosive eruptions in two ways that are poorly understood: 1) by modulating the hydrostatic pressure within the conduit and at the vent, and 2) through the ingestion and mixing of external water, which governs fine ash production and eruption column buoyancy flux. To make progress, we couple one-dimensional models of conduit flow and atmospheric column rise through a novel “magma-water interaction” model that simulates the occurrence, extent and consequences of water entrainment depending on the depth of a surface water layer. We explore the effects of hydrostatic pressure on magma ascent in the conduit and gas decompression at the vent, and the conditions for which water entrainment drives fine ash production by quench fragmentation, eruption column collapse, or outright failure of the jet to breach the water surface. We show that the efficiency of water entrainment into the jet is the predominant control on jet behavior. For an increase in water depth of 50–100 m, the critical magma mass eruption rate required for eruption columns to reach the tropopause increases by an order of magnitude. Finally, we estimate that enhanced emission of fine ash leads to up to a 2-fold increase in the mass flux of particles < 125 μm to spreading umbrella clouds, together with up to a 10-fold increase in water mass flux, conditions that can enhance the removal of SO2 via chemical scavenging and ash sedimentation. On average, compared to purely magmatic eruptions, we suggest that hydrovolcanic eruptions will be characterized by reduced climate forcing. Our results suggest one possible mechanism for volcano-climate feedback: temporal changes with climate in surface distributions of water and ice may modify the relative global frequency or dominance of hydrovolcanic eruption processes, modulating, in turn, global patterns in volcano-climate forcing.
Cenozoic Uplift of Tanggula Range and Tuouohe Basin, Northern Tibet: Insights of the Anisotropy of Magnetic Susceptibility
Authors: Li Leyi , Chang Hong , Pares Josep M. , Bradák Balázs , Zhang Zeke , Qiang Xiaoke , Guan Chong , Quan Chunyan 
Published: April 2022

The timing and intensity of deformation of the Tanggula Range and Tuotuohe Basin are in debatable but strengthening the research on them is necessary for better understanding the geodynamic models of the Tibet and the tectonic-climate connections during the Cenozoic. Here we present the anisotropy of magnetic susceptibility (AMS) records from the foreland Tuotuohe Basin to understand the tectonic uplift history of the Tanggula Range for the interval of ∼37–19.7 Ma. Rock magnetic analyses indicate that the main magnetic carrier is paramagnetic and the minor is hematite. Thus, the AMS in the Tuotuohe Section (TS) can be used to track the tectonic strain related to tectonic processes. The distribution direction of the maximum principle susceptibility (Kmax) is approximately NW–SE, which intersects at about 10°with the strike of the strata and is nearly parallel to the Tanggula thrust fault system, whereas the minimum principle susceptibility (Kmin) is oriented in the NE–SW direction with a girdle distribution. This is consistent with the sedimentary fabric imprinted by the NE–SW shortening direction, representing the earliest deformation stage. AMS data in the TS can be divided into two phases at 30 Ma. From ∼37 to 30 Ma, the AMS parameters indicate an active tectonic strain and the Tanggula Range uplift induced by the India–Asia convergence, whereas between 30 and 19.7 Ma, the strain is weak compared with the earlier phase. Finally, the weak strain environment between 30 and 19.7 Ma indicated by the AMS indexes of the TS and the paleoelevation evidence from the Tuotuohe Basin all together suggest that an additional 1000–2000 m of surface uplift of the basin may have begun after 19.7 Ma.
Improper Maintenance Activities Alter Benefits of Urban Stormwater Treatment in a Temperate Constructed Wetland in NSW, Australia
Authors: Wright Aaron S. , Doblin Martina A. , Scanes Peter R. 
Published: April 2022

Constructed wetlands (CWs) are an effective means to treat nutrient and sediment pollution in urban stormwater runoff to minimise impact on receiving waterways. Maintenance of devices is recognised as a major contributing factor to performance. There is a lack of evidence-based guidance on maintenance activities to optimise treatment, due to a paucity of data from long-term field studies into CW performance before and after maintenance. In this study, the nutrient and sediment removal efficiency (% RE) of a CW was evaluated by calculating removal efficiencies of nitrogen (N), phosphorus (P) and total suspended sediment (TSS) following a long-term sampling program under baseflow and event flow conditions. Sampling was carried out before, during and after maintenance. Maintenance involved removing all aquatic vegetation and 200–300 mm of sediments over a 3-week period, aiming to improve the wetland’s performance. Assessment of dissolved and particulate nutrient fractions allowed a comprehensive investigation into drivers of nutrient removal efficiency. Under baseflow conditions differences in inflow and outflow pollutant concentrations were used to calculate removal efficiency and pollutant loads were used during event flow conditions. Before maintenance, during baseflow conditions the wetland was removing total N (36% RE) but exporting total P (-52% RE) and total sediment (-94% RE). During event-flow conditions all target pollutants were being removed (total N 63% RE, total P 25% RE and TSS 69% RE). phosphorusDuring maintenance, the device continued to remove total N (18% RE) but the physical disturbance of the maintenance resulted in mass export of total P (-120% RE) and total sediment (−2,000% RE) over a short time period, effectively undoing previous treatment. After maintenance, during baseflow conditions, the wetlands’ ability to treat total N decreased (28% RE), improved for total P (1% RE), and became a chronic source of suspended sediment (−127% RE). During event flow conditions, total N was no longer being treated (−19%) but total P and total suspended sediment were being retained (74%, 80% RE respectively). This study showed that the physical disturbance resulting from large-scale maintenance activities can potentially reverse years’ worth of treatment if not adequately planned and carried out with suitable controls.
A Rare Presentation Characterized by Epileptic Spasms in ALDH7A1, Pyridox(am)ine-5′-Phosphate Oxidase, and PLPBP Deficiency
Authors: Jiao Xianru , Gong Pan , Niu Yue , Zhang Yuehua , Yang Zhixian 
Published: April 2022

Objective: To analyze the clinical feature, treatment, and prognosis of epileptic spasms (ES) in vitamin B6–dependent epilepsy, including patients with pyridoxine-dependent epilepsy (PDE) caused by ALDH7A1 mutation, pyridox(am)ine-5′-phosphate oxidase (PNPO) deficiency, and PLPBP deficiency.Methods: We analyzed data from a cohort of 54 cases with PDE, 13 cases with PNPO deficiency, and 2 cases with PLPBP deficiency and looked for the presentation of ES among them.Results: A total of 11 patients with the seizure presentation of ES have been collected. Among them, four patients carried mutations in ALDH7A1, six carried mutations in PNPO, and the remaining one carried mutation in PLPBP. The analysis of this cohort identified nine cases presenting as infantile spasms distributed in the three diseases and two cases presenting as Ohtahara syndrome diagnosed with PDE and PNPO deficiency, respectively. In the PDE and PLPBP deficiency groups, seizures were controlled by pyridoxine monotherapy, and the remaining one had refractory seizures due to secondary brain atrophy. In the groups with PNPO deficiency, one patient showed seizure-free when treated by PLP combined with valproic acid, three still had infrequent seizures treated by PLP monotherapy or pyridoxine or PLP combined with other antiseizure medications, and two died. In two cases presenting as Ohtahara syndrome, after regular treatment, one showed seizure-free, the others showed a marked decrease in seizure frequency, and they both showed an improvement in EEG.Significance: ES might be a common form of seizures in PNPO deficiency, and EEG presented as hypsarrhythmia or a burst suppression pattern. It is difficult for pyridoxine to control frequent seizures caused by secondary brain injury. In our PNPO deficiency cohort, patients with infantile spasms did not respond better to PLP than pyridoxine. Timely and correct treatment could prevent the transformation of the child’s disease from Ohtahara syndrome and infantile spasms to subsequent epileptic encephalopathy or refractory epilepsy.
Identification of Neutrophil-Related Factor LCN2 for Predicting Severity of Patients With Influenza A Virus and SARS-CoV-2 Infection
Authors: Huang Zhisheng , Li Hui , Liu Shuai , Jia Ju , Zheng Ying , Cao Bin 
Published: April 2022

BackgroundInfluenza and COVID-19 are respiratory infectious diseases that are characterized by high contagiousness and high mutation and pose a serious threat to global health. After Influenza A virus (IAV) and SARS-CoV-2 infection, severe cases may develop into acute lung injury. Immune factors act as an important role during infection and inflammation. However, the molecular immune mechanisms still remain unclear. We aimed to explore immune-related host factors and core biomarker for severe infection, to provide a new therapeutic target of host factor in patients.MethodsGene expression profiles were obtained from Gene Expression Omnibus and the Seurat R package was used for data process of single-cell transcriptome. Differentially expressed gene analysis and cell cluster were used to explore core host genes and source cells of genes. We performed Gene Ontology enrichment, Kyoto Encyclopedia of Genes and Genomes analysis, and gene set enrichment analysis to explore potential biological functions of genes. Gene set variation analysis was used to evaluate the important gene set variation score for different samples. We conduct Enzyme-linked immunosorbent assay (ELISA) to test plasma concentrations of Lipocalin 2 (LCN2).ResultsMultiple virus-related, cytokine-related, and chemokine-related pathways involved in process of IAV infection and inflammatory response mainly derive from macrophages and neutrophils. LCN2 mainly in neutrophils was significantly upregulated after either IAV or SARS-CoV-2 infection and positively correlated with disease severity. The plasma LCN2 of influenza patients were elevated significantly compared with healthy controls by ELISA and positively correlated with disease severity of influenza patients. Further bioinformatics analysis revealed that LCN2 involved in functions of neutrophils, including neutrophil degranulation, neutrophil activation involved in immune response, and neutrophil extracellular trap formation.ConclusionThe neutrophil-related LCN2 could be a promising biomarker for predicting severity of patients with IAV and SARS-CoV-2 infection and may as a new treatment target in severe patients.
Eliciting Implicit Awareness in Alzheimer’s Disease and Mild Cognitive Impairment: A Task-Based Functional MRI Study
Authors: Tondelli Manuela , Benuzzi Francesca , Ballotta Daniela , Molinari Maria Angela , Chiari Annalisa , Zamboni Giovanna 
Published: April 2022

BackgroundRecent models of anosognosia in dementia have suggested the existence of an implicit component of self-awareness about one’s cognitive impairment that may remain preserved and continue to regulate behavioral, affective, and cognitive responses even in people who do not show an explicit awareness of their difficulties. Behavioral studies have used different strategies to demonstrate implicit awareness in patients with anosognosia, but no neuroimaging studies have yet investigated its neural bases.MethodsPatients with amnestic mild cognitive impairment and dementia due to Alzheimer’s disease underwent functional magnetic resonance imaging (fMRI) during the execution of a color-naming task in which they were presented with neutral, negative, and dementia-related words (Dementia-Related Emotional Stroop).ResultsTwenty-one patients were recruited: 12 were classified as aware and 9 as unaware according to anosognosia scales (based on clinical judgment and patient-caregiver discrepancy). Behavioral results showed that aware patients took the longest time to process dementia-related words, although differences between word types were not significant, limiting interpretation of behavioral results. Imaging results showed that patients with preserved explicit awareness had a small positive differential activation of the posterior cingulate cortex (PCC) for the dementia-related words condition compared to the negative words, suggesting attribution of emotional valence to both conditions. PCC differential activation was instead negative in unaware patients, i.e., lower for dementia-related words relative to negative-words. In addition, the more negative the differential activation, the lower was the Stroop effect measuring implicit awareness.ConclusionPosterior cingulate cortex preserved response to dementia-related stimuli may be a marker of preserved implicit self-awareness.
Tobacco and ADHD: A Role of MAO-Inhibition in Nicotine Dependence and Alleviation of ADHD Symptoms
Authors: Taylor Mairin Rose , Carrasco Kelly , Carrasco Andres , Basu Arindam 
Published: April 2022

Attention-deficit/hyperactivity disorder (ADHD) is a relatively commonly occurring neurodevelopmental disorder affecting approximately 5% of children and young people. The neurobiological mechanisms of ADHD are proposed to particularly center around increased dopamine receptor availability related to associated symptoms of reduced attention regulation and impulsivity. ADHD is also persistent across the lifespan and associated with a raft of impulsive and health-risk behaviors including substance abuse and smoking. Research highlighting the potentially significant levels of monoamine oxidase (MAO) inhibitory properties in tobacco smoke and e-cigarettes may provide a mechanism for increased tobacco smoke dependence among those with ADHD, in addition to the role of nicotine.AimThis scoping review aimed to establish evidence for the above neurobiological pathway between smoking and ADHD symptom-alleviation or “self-medication” with the inclusion of the mechanism of MAO-inhibitors indirect increasing dopamine in the brain.MethodologyScoping review methodologies were employed in this review selected to synthesize multiple sources of empirical research to identify current gaps in the knowledge base and identify key characteristics of research data related to a phenomenon. Databases searched included OVID MEDLINE(R), Embase, Cochrane, PsycINFO and SCOPUS limited to 2000 onward and empirically validated, peer-reviewed research.FindingsThere is support for the role of MAO-inhibition on greater reinforcement of smoking for individuals with ADHD through a greater impact on dopaminergic availability than nicotine; potentially moderating ADHD symptoms.ConclusionGreater support for a “self-medication” model of ADHD and smoking includes not only nicotine but also MAO-inhibitors as dopamine agonists contained in cigarettes and e-cigarettes.
Radiomics Nomogram for Predicting Stroke Recurrence in Symptomatic Intracranial Atherosclerotic Stenosis
Authors: Tang Min , Gao Jie , Ma Niane , Yan Xuejiao , Zhang Xin , Hu Jun , Zhuo Zhizheng , Shi Xiaorui , Li Ling , Lei Xiaoyan , Zhang Xiaoling 
Published: April 2022

ObjectiveTo develop and validate a radiomics nomogram for predicting stroke recurrence in symptomatic intracranial atherosclerotic stenosis (SICAS).MethodsThe data of 156 patients with SICAS were obtained from the hospital database. Those with and without stroke recurrence were identified. The 156 patients were separated into a training cohort (n = 110) and a validation cohort (n = 46). Baseline clinical data were collected from our medical records, and plaque radiological features were extracted from vascular wall high-resolution imaging (VW-HRMRI). The imaging sequences included 3D-T1WI-VISTA, T2WI, and 3D-T1WI-VISTA-enhanced imaging. Least absolute shrinkage and selection operator (LASSO) analysis were used to select the radiomics features associated with stroke recurrence. Then, multiple logistic regression analysis of clinical risk factors, radiological features, and radiomics signatures were performed, and a predictive nomogram was constructed to predict the probability of stroke recurrence in SICAS. The performance of the nomogram was evaluated.ResultsDiabetes mellitus, plaque burden, and enhancement ratio were independent risk factors for stroke recurrence [odds ratio (OR) = 1.24, 95% confidence interval (CI): 1.04–3.79, p = 0.018; OR = 1.76, per 10% increase, 95% CI, 1.28–2.41, p &lt; 0.001; and OR = 1.94, 95% CI: 1.27–3.09, p &lt; 0.001]. Five features of 3D-T1WI-VISTA, six features of T2WI, and nine features of 3D-T1WI-VISTA-enhanced images were associated with stroke recurrence. The radiomics signature in 3D-T1WI-VISTA-enhanced images was superior to the radiomics signature of the other two sequences for predicting stroke recurrence in both the training cohort [area under the curve (AUC), 0.790, 95% CI: 0.669–0.894] and the validation cohort (AUC, 0.779, 95% CI: 0.620–0.853). The combination of clinical risk factors, radiological features, and radiomics signature had the best predictive value (AUC, 0.899, 95% CI: 0.844–0.936 in the training cohort; AUC, 0.803, 95% CI: 0.761–0.897 in the validation cohort). The C-index of the nomogram was 0.880 (95% CI: 0.805–0.934) and 0.817 (95% CI: 0.795–0.948), respectively, in the training and validation cohorts. The decision curve analysis further confirmed that the radiomics nomogram had good clinical applicability with a net benefit of 0.458.ConclusionThe radiomics features were helpful to predict stroke recurrence in patients with SICAS. The nomogram constructed by combining clinical high-risk factors, plaque radiological features, and radiomics features is a reliable tool for the individualized risk assessment of predicting the recurrence of SICAS stroke.
High-Throughput Chinmedomics Strategy Discovers the Quality Markers and Mechanisms of Wutou Decoction Therapeutic for Rheumatoid Arthritis
Authors: Li Taiping , Wu Fangfang , Zhang Aihua , Dong Hui , Ullah Ihsan , Lin Hao , Miao Jianhua , Sun Hui , Han Ying , He Yanmei , Wang Xijun 
Published: April 2022

Wutou decoction (WTD) is a traditional Chinese medicine prescription for the treatment of rheumatoid arthritis (RA), and this study systematically analyzed the metabolic mechanism and key pharmacodynamic components of WTD in RA rats by combining untargeted metabolomics and serum pharmacochemistry of traditional Chinese medicine to enrich the evidence of WTD quality markers (Q-markers) studies. WTD prevented synovial edema in RA rats and reduced tumor necrosis factor-alpha and interleukin 6 levels in rat serum, according to the results of an enzyme-linked immunosorbent examination and histopathological inspection. In model rats, pattern recognition and multivariate statistical analysis revealed 24 aberrant metabolites that disrupted linoleic acid metabolism, arachidonic acid metabolism, arginine and proline metabolism, etc. However, continued dosing of WTD for 28 days reversed 13 abnormal metabolites, which may be an important therapeutic mechanism from a metabolomic perspective. Importantly, 12 prototypical components and 16 metabolites from WTD were characterized in RA rat serum. The results of Pearson correlation analysis showed that aconitine, L-ephedrine, L-methylephedrine, quercetin, albiflorin, paeoniflorigenone, astragaline A, astragaloside II, glycyrrhetic acid, glycyrrhizic acid, licurazide, and isoliquiritigenin are the key pharmacological components that regulate the metabolism of RA rats, and they are identified as Q-markers. In sum, utilizing metabolomics and serum pharmacochemistry of traditional Chinese medicine, the metabolic mechanisms and Q-markers of WTD therapy in RA rats were revealed, providing a theoretical basis for the quality control investigation of WTD.
Prescription of Potentially Inappropriate Medication Use in Older Cancer Outpatients With Multimorbidity: Concordance Among the Chinese, AGS/Beers, and STOPP Criteria
Authors: Tian Fangyuan , Zhao Mengnan , Chen Zhaoyan , Yang Ruonan 
Published: April 2022

Objectives: Age-related multimorbidity is a general problem in older patients, which increases the prevalence of potentially inappropriate medication (PIM) use. This study aimed to examine the prevalence and predictors of PIM use in older Chinese cancer outpatients with multimorbidity based on the 2017 Chinese criteria, 2019 AGS/Beers criteria, and 2014 STOPP criteria.Methods: A cross-sectional study was conducted using electronic medical data from nine tertiary hospitals in Chengdu from January 2018 to December 2018. The 2017 Chinese criteria, 2019 AGS/Beers criteria, and 2014 STOPP criteria were used to evaluate the PIM status of older cancer outpatients (age ≥65 years), the concordance among the three PIM criteria was calculated using kappa tests, and multivariate logistic regression was used to identify the risk factors associated with PIM use.Results: A total of 6,160 cancer outpatient prescriptions were included in the study. The prevalence of PIM use was 34.37, 32.65, and 15.96%, according to the 2017 Chinese criteria, 2019 AGS/Beers criteria, and 2014 STOPP criteria, respectively. Furthermore, 62.43% of PIMs met table 2, 0.27% of PIMs met table 3, 34.68% of PIMs met table 4, 2.62% of PIMs met table 5 of 2019 AGS/Beers criteria, respectively. According to the three criteria, 84.93%, 82.25%, and 94.61% of older cancer outpatients had one PIM. The most frequently used PIM in cancer outpatients was estazolam. The Chinese criteria and the STOPP criteria indicated poor concordance, whereas the 2019 AGS/Beers criteria showed moderate concordance with the other two criteria. Logistic regression demonstrated that age ≥ 80, more diseases, polypharmacy, irrational use of drugs, and lung cancer were positively associated with PIM use in older cancer outpatients.Conclusion: The prevalence of PIM use in Chinese older cancer outpatients with multimorbidity is high in China, and poor-to-moderate concordance among the three criteria was observed. Research on building PIM criteria for the older cancer population is necessary in the future.