bluuebunny/crossref_metadata_2025_split huggingface dataset:
ERRα Attenuates Vascular Inflammation via Enhanced NFκB Degradation Pathway
Authors: Yamamoto Hiroyasu , Tanaka Yuya , Sawada Miho , Kihara Shinji 
Published: December 2022

Abstract
We have previously reported that β-aminoisobutyric acid (BAIBA), a muscle-derived exercise mimetic, had anti-inflammatory and reactive oxygen species (ROS) scavenging effects in vascular endothelial cells through the enhanced expression of peroxisome proliferator-activated receptor gamma coactivator-1β (PGC-1β). Although BAIBA also increased the expression of estrogen-related receptor α (ERRα), the roles of ERRα in vascular endothelial cells have yet to be fully elucidated. Here, we found that human aortic endothelial cells (HAECs) infected with ERRα-expressing adenovirus had significantly decreased mRNA levels of tumor necrosis factor α–stimulated proinflammatory molecules. However, ERRα overexpression had little effect on the mRNA levels of PGC-1β, peroxisome proliferator-activated receptors, and almost all ROS scavenging molecules, except for superoxide dismutase 2. ERRα expression significantly decreased NFκB reporter activities in a dose-dependent manner with unaltered IκBα phosphorylation levels but with a significant increase in the mRNA levels of PDZ and LIM domain protein 2 (PDLIM2) and copper metabolism gene MURR1 domain-containing protein (COMMD1), which enhance the ubiquitination and degradation of NFκB. Also, PDLIM2 and COMMD1 mRNA levels were upregulated in BAIBA-treated HAECs. Finally, we identified the ERRα-response element in the COMMD1 promoter region (−283 to −29 bp). These results indicated that ERRα exerted anti-inflammatory effects in vascular endothelial cells through COMMD1-mediated attenuation of NFκB activity, which could be an atheroprotective mechanism of physical exercise.
Dynamical Interaction Analysis of Proteins by a Random Forest-Fragment Molecular Orbital (RF-FMO) Method and Application to Src Tyrosine Kinase
Authors: Yamamoto Yuta , Nakano Shogo , Shigeta Yasuteru 
Published: December 2022

Abstract
Identifying key intermolecular (amino acid) interactions is crucial for understanding intrinsic protein functions. In this study, we established an efficient method for discovering key interactions by combining the random forest (RF) method, a machine learning algorithm, and an interaction analysis based on the fragment molecular orbital (FMO) method.
We applied this method to Src tyrosine kinase and verified its efficacy. We performed molecular dynamics simulations of both the open and closed forms of Src and selected 50 snapshots for each. Then, pair interaction energy (PIE) or inter-fragment interaction energy (IFIE) analyses were performed using FMO with the van der Waals (vdW)-corrected density functional tight-binding (DFTB) method. Among the 100 × 34453 data sets, we can identify the key amino acid pair regulating the open-close transition. This is consistent with the experimental and theoretical results, indicating the usefulness of the presented method. In contrast to the conventional FMO PIE interaction analysis, in the proposed method, the protein dynamics can be partially included using hundreds of trajectory data.
Νήσος Ορθοδόξων: Ο Αρχιμανδρίτης Κυπριανός και η θρησκευτική Ανθρωπογεωγραφία της Μεσαιωνικής και πρώϊμης Νεότερης Κύπρου
Authors: ΚΥΡΙΑΚΟΥ Χρυσοβαλάντης 
Published: December 2022

Στόχος του παρόντος άρθρου είναι η εξέταση του τρόπου με τον οποίο ο Αρχιμανδρίτης Κυπριανός (πεθ. 1802–1805) παρουσιάζει τη θρησκευτική ανθρωπογεωγραφία της Κύπρου, από τους βυζαντινούς χρόνους (324–1191) μέχρι τη δική του εποχή, όταν πλέον το νησί βρισκόταν στα χέρια των Οθωμανών (1571–1878), μετά από μια μακρά ενδιάμεση περίοδο λατινικής κυριαρχίας (1191–1571).To άρθρο μελετά τον Κυπριανό ως ιστορικό του θρησκευτικού χώρου της Κύπρου, εστιάζοντας στο πώς επιλέγει να παρουσιάσει τις διάφορες χριστιανικές ομάδες και τις μεταξύ τους εκκλησιαστικές σχέσεις και συγκρίνοντας το έργο του με εκείνο του Steffano Lusignano και του Λογίζου Σκευοφύλακα.
Presidentialization of the form of government in Kyrgyzstan as a political process factor: causes and prospects
Authors: Borisov Nikolay 
Published: December 2022

The purpose of the article is to analyze the main changes in the system of government in Kyrgyzstan after the 2020 coup, including the form of government and the electoral system in the context of the factors of these changes and their potential impact on the political process in the republic in terms of its stability. As a research methodology, the interval method of M.S. Shugart and J. Carey (assessment of legislative and non-legislative powers of the president, followed by the distribution of cases by clusters) and the methodology of A. Crowel with additions by O.I. Zaznaev (assessment of the presidential and parliamentary index of the form of government, followed by the determination of the degree of presidentialization or parliamentarization) are used.
The next changes in Kyrgyzstan’s form of government were caused by the political elite change as a result of the 2020 coup. The parliamentary form of government was replaced by a presidentialized semi-presidential form of government, in which the main powers are concentrated in the hands of the president, who heads the executive branch. To ensure political stability, the new elites found the simplest and most obvious way out – a return to presidentialism. The proportional electoral system was replaced by a mixed, unrelated system. However, a “strong” president by himself is not capable of becoming the main factor of stability. In the absence of a parliamentary majority supporting the president, acute political crises may arise, but the procedure for resolving them is absent in the constitution. On the other hand, the high role of informal institutions and clan-regional ties can not only hinder, but also contribute to political stability especially due to the preservation of the “northern” and “southern” elites’ consensus. The formalization of a “strong” president in this sense creates more foundations for stabilizing the situation. The parliamentary and presidential elections will once again be the next test for countering these threats. The theoretical significance of the work lies in the fact that the conclusions drawn from the Kyrgyzstan case will clarify the political consequences of the use of certain forms of government and their impact on the political process in a comparative perspective.
30 lat później – neolit ziemi chełmińskiej w badaniach Zakładu Młodszej Epoki Kamienia
Authors: Gwardecki Mateusz , Kowalski Łukasz , Kozicka Magdalena , Sosnowski Mateusz 
Published: December 2022

W latach 80. ubiegłego wieku w Instytucie Archeologii i Etnografii Uniwersytetu Mikołaja Kopernika rozpoczęto realizację programu badań nad neolitem ziemi chełmińskiej. Od samego początku był on trwale związany z projektem Archeologicznego Zdjęcia Polski. W wyniku podjętych prac na obszarze dawnego województwa toruńskiego zlokalizowano około 2500 stanowisk archeologicznych z młodszej epoki kamienia, z których około 120 przebadano metodą wykopaliskową. Pozyskano źródła archeologiczne od wczesnych faz kultury ceramiki wstęgowej rytej aż do schyłku kultury ceramiki sznurowej. Pozwala to na prowadzenie przez Zakład Młodszej Epoki Kamienia, a w jego ramach przez autorów tego opracowania, wieloaspektowych studiów nad społecznościami neolitycznymi. Skupiają się one wokół kwestii związanych z mentalnością społeczności pradziejowych, modelowaniem bayesowskim oznaczeń radiowęglowych, dynamiką osadnictwa społeczności wczesnorolniczych i warunków współczesnego ich manifestowania się w przestrzeni geograficznej ziemi chełmińskiej, czy badań nad najstarszą metalurgią na ziemiach polskich.
Niektóre zagadnienia badawcze realizowane w Zakładzie Młodszej Epoki Kamienia są bliższe klasycznej archeologii, inne projekty wychodzą naprzeciw nieco innej formie jej uprawiania, inspirowanej konstruktywizmem kulturowym oraz badaniami poznańskiej szkoły kulturoznawczej. Czynnikiem integrującym działalność Zakładu Młodszej Epoki Kamienia jest silne przekonanie o potrzebie realizacji postulatu pluralizmu poznawczego, który ma abstrahować od konwencjonalnych granic dyscyplin. Zakładamy, że paradygmatem, który pozwoli na urzeczywistnienie postulatu badań transdyscyplinarnych jest konstruktywizm kulturowy.
Ikonografia jako element warsztatu badawczego w archeologii antycznej. Studia nad mozaiką rzymską z Leptis Magna w kontekście procesu romanizacji miast Afryki Północnej
Authors: Mosiejczyk Jakub 
Published: December 2022

Analiza źródeł ikonograficznych stanowi nieodłączny element w studiach nad przeszłością człowieka. Jednak włączenie materialnych pozostałości kultury wizualnej w proces rekonstrukcji dziejów przywołuje stary spór kompetencyjny między badaczami, którzy skłonni są raczej pozostawić tę domenę wyłącznie historykom sztuki. Nie ulega wątpliwości, że na gruncie tej właśnie dyscypliny wykształcono podstawowe metody badawcze: ikonograficzną (opisową) i ikonologiczną (interpretacyjną), które stanowią podstawę rozważań nad treścią przedstawień. W opracowaniu skoncentrowano się na specyfice tych źródeł w archeologii. W tym celu zostały przywołane najnowsze studia z zakresu antycznej ikonografii prowadzone w ośrodku toruńskim; dotyczą one między innymi monet, ceramiki figurowej, posadzek mozaikowych. Te ostatnie stanowią szczególną kategorię źródeł starożytnej ikonografii, wykorzystywanych do rekonstrukcji procesów historycznych. W dobie Imperium Romanum technikę ich wykonywania opanowano do perfekcji i rozpowszechniono w kręgu elit, z tego powodu uważane są za jeden z symboli rzymskiej cywilizacji. Idea ta była wspólna dla kultury basenu Morza Śródziemnego – obecna w starożytnej Grecji, punickiej Kartaginie i królestwach hellenistycznych.
Region Północnej Afryki w dobie cesarstwa rzymskiego jawi się na tym tle niezwykle interesująco. W żadnej innej prowincji zdobnictwo posadzkowe nie występowało na tak szeroką skalę. Należy też wskazać na różnorodność stosowanych na przestrzeni trzech pierwszych wieków naszej ery motywów, co jest wynikiem ścierania się warsztatów je produkujących, ale także odzwierciedleniem zróżnicowania lokalnych elit. Wyróżnić tu można warsztaty tradycji hellenistycznej (często nazywane warsztatami aleksandryjskimi) oraz działalnością pracowni lokalnych (tzw. prowincjonalno-rzymskich).
Application of botulinum toxin in the treatment of bruxism
Authors: Milanowska Małgorzata , Dudzińska Paulina , Grudzińska Aleksandra , Jarosz Dominika , Tsitko Hanna 
Published: December 2022

Bruxism is a commonly reported functional para-function of the oral cavity. Its symptoms are quite characteristic and include, above all, excessive clenching and grinding of the teeth. (2) Other complaints most frequently reported by patients are headaches, pain in the temporomandibular joint, excessive tooth abrasion, damage to dentures, waking up at night, visual effect - the so-called "square jaw". The etiology is multifactorial therefore it is difficult to treat its symptoms.
Botulinum toxin is a neurotoxin produced by the anaerobic bacteria Clostridium botulinum. Its mechanism is based on the reversible inhibition of acetylcholine release in neuromuscular junctions. Intramuscular injection of botulinum toxin is one of the treatments of bruxism. So far, this method is used off-label. Looking at the promising results of randomized studies on the use of botulinum toxin in bruxism, this may change in the near future. As shown by previous studies, it is not an ideal method, but nevertheless it is one of the most effective and the best for the patient. The downside to the use of botulinum toxin in the treatment of bruxism symptoms are, inter alia, contraindications to the use of this drug and the duration of its action - 3-6 months.
This systematic review of selected articles and studies aims to examine the available literature in order to determine the effectiveness of the use of botulinum toxin in the treatment of bruxism and to assess whether it is currently the most effective method.
Pubmed and Google Scholar were searched for literature.
Husserlowska wariacja imaginacyjna i problem jej wykonalności w kontekście rozważań Romana Ingardena
Authors: Gilicka Magdalena 
Published: December 2022

Niniejszy artykuł prezentuje zagadnienie operacji wariacji imaginacyjnej w perspektywie problemu jej wykonalności oraz samej zasadności jej przeprowadzenia. Koncepcję wariacji imaginacyjnej nierozerwalnie wiążę z kategoriami transcendencji oraz konstytuującej świadomości. W pierwszej części pracy dokonuję wstępnej charakterystyki operacji uzmienniania. W drugiej części prezentuję zarzuty Romana Ingardena, jakie wystosował w swoich Uwagach krytycznych, w stronę możliwości i zasadności jej wykonalności.
Evaluación del proceso de implementación de un programa en habilidades para la vida para la prevención del consumo de sustancias en escuelas públicas de Córdoba (Argentina).
Authors: Bertea Francisco , Cardozo Griselda 
Published: December 2022

Se presenta una evaluación del proceso de implementación de un Programa en Habilidades para la vida orientado a la prevención del consumo de sustancias, documentando aspectos complejos para formular recomendaciones para futuras aplicaciones. Para realizar la evaluación, se seleccionaron siete cursos en los cuales se efectuó la intervención. Participaron de la experiencia 14 docentes y 200 alumnos pertenecientes a un ámbito socioeconómico y cultural medio-bajo, que cursaban el primer y cuarto año de escuelas públicas del nivel secundario de la ciudad de Córdoba (Argentina). Se emplearon técnicas cualitativas de recolección de información (observación no participante, registro de producciones de las actividades y entrevistas grupales). Se realizó un análisis interpretativo – hermenéutico de los datos. Los resultados demuestran la utilidad de este tipo de evaluaciones para conocer la calidad del proceso de implementación de programa, y la complejidad del trabajo de implementación de programas orientados al fortalecimiento de habilidades para la vida en contextos escolares públicos.
Flexibility and Consistency in Long-Term Care Rostering
Authors: Slaugh Vincent W. , Scheller-Wolf Alan A. 
Published: December 2022

Problem definition: We consider the rostering decisions—that is, the assignment of workers scheduled for a shift to units—of a long-term care facility. The facility’s objective is to minimize the monthly inconsistency level, a widely promoted quality metric representing the number of different caregivers working in each unit over one month. Methodology/results: We introduce simple rostering heuristics that prioritize either part-time or full-time workers and present a stochastic model of the repeated rostering problem to compare the performance of different strategies analytically. Our analysis shows that in order to minimize the inconsistency level, part-time workers should receive higher priority than full-time workers for assignment to their home units. We also establish an analytical upper bound for a threshold on the time horizon above which a policy giving assignment priority to part-time workers is guaranteed to outperform one giving priority to full-time workers. Using data from more than 15,000 shifts worked by nursing assistants at three nursing homes, we compare the actual rosters to the hindsight optimal consistency-maximizing schedules, demonstrating a significant opportunity for improvement. We then compare the performance of our rostering heuristics via trace-based simulation of the historical schedules. This reinforces the superiority of prioritizing part-time workers, yielding reductions in the inconsistency level between 20% and 30% compared with the historical rosters. Managerial implications: Contrary to popular guidance, our results show that managers should focus on part-time workers and assign them as consistently as possible. Even if some full-time workers are always assigned to their home units (because of preferences or work rules), assignment flexibility among the remaining full-time workers still enables significant improvements in the consistency of care. This flexibility among full-time workers helps because their higher work frequency tends to make a reassignment away from their home unit contribute less to inconsistency, because they are able to work multiple shifts in these nonhome units. Supplemental Material: The e-companion is available at https://doi.org/10.1287/msom.2022.1174 .
Effect of Chinese herbal medicine formula on progression-free survival among patients with metastatic colorectal cancer: Study protocol for a multi-center, double-blinded, randomized, placebo-controlled trial
Authors: Wang Qiaoling , Li Zhuohong , Guo Jing , Li Wenyuan , You Fengming 
Published: December 2022

Introduction
Metastatic colorectal cancer (mCRC) causes high cancer-related morbidity and mortality worldwide. Although chemotherapy and targeted agents treatment improve median survival and 5-year survival rates, there is only one-third of patients who adhere to treatment protocol until the pause of disease progression. Hezhong granule is a traditional Chinese herbal formula used for mCRC, which has shown good potential in alleviating the adverse effects of chemotherapy, enhancing the effectiveness of chemotherapy, and improving the quality of life. Therefore, the purpose of the study is to further validate the clinical efficacy and safety of the Chinese herbal medicine formula named Hezhong (HZ) in combination with standard chemotherapy and cetuximab (CET) or bevacizumab (BV) for treating mCRC.

Methods
In this multi-center, randomized, double-blinded, placebo-controlled trial, 360 eligible mCRC patients who will be randomly assigned to Hezhong or placebo group with a 1: 1 ratio. Participants in the Hezhong group will receive standard chemotherapy and CET or BV plus Hezhong Granule until the pause of disease progression, death, the exhibition of intolerable toxicity, or up to 6 months, while the placebo group will treat with standard chemotherapy and CET or BV plus placebo. The primary endpoint is progression-free survival (PFS). The secondary endpoints are overall survival (OS), objective response rate (ORR), safety, quality of life years (QOL), and chemotherapy-induced nausea and vomiting (CINV).

Expected results
The expected results of this trial are to improve the PFS and QOL of patients with mCRC and provide evidence-based recommendations for the treatment of mCRC with traditional Chinese medicine in China.

Trial registration
The trial has been registered with the Chinese Clinical Trial Registry (ChiCTR). The trial registration number was ChiCTR2100041643.
Clinical practice guideline adherence in oncology: A qualitative study of insights from clinicians in Australia
Authors: Bierbaum Mia , Rapport Frances , Arnolda Gaston , Delaney Geoff P. , Liauw Winston , Olver Ian , Braithwaite Jeffrey 
Published: December 2022

Background
The burden of cancer is large in Australia, and rates of cancer Clinical Practice Guideline (CPG) adherence is suboptimal across various cancers.

Methods
The objective of this study is to characterise clinician-perceived barriers and facilitators to cancer CPG adherence in Australia. Semi-structured interviews were conducted to collect data from 33 oncology-focused clinicians (surgeons, radiation oncologists, medical oncologists and haematologists). Clinicians were recruited in 2019 and 2020 through purposive and snowball sampling from 7 hospitals across Sydney, Australia, and interviewed either face-to-face in hospitals or by phone. Audio recordings were transcribed verbatim, and qualitative thematic analysis of the interview data was undertaken. Human research ethics committee approval and governance approval was granted (2019/ETH11722, #52019568810127).

Results
Five broad themes and subthemes of key barriers and facilitators to cancer treatment CPG adherence were identified: Theme 1: CPG content; Theme 2: Individual clinician and patient factors; Theme 3: Access to, awareness of and availability of CPGs; Theme 4: Organisational and cultural factors; and Theme 5: Development and implementation factors. The most frequently reported barriers to adherence were CPGs not catering for patient complexities, being slow to be updated, patient treatment preferences, geographical challenges for patients who travel large distances to access cancer services and limited funding of CPG recommended drugs. The most frequently reported facilitators to adherence were easy accessibility, peer review, multidisciplinary engagement or MDT attendance, and transparent CPG development by trusted, multidisciplinary experts. CPGs provide a reassuring framework for clinicians to check their treatment plans against. Clinicians want cancer CPGs to be frequently updated utilising a wiki-like process, and easily accessible online via a comprehensive database, coordinated by a well-trusted development body.

Conclusion
Future implementation strategies of cancer CPGs in Australia should be tailored to consider these context-specific barriers and facilitators, taking into account both the content of CPGs and the communication of that content. The establishment of a centralised, comprehensive, online database, with living wiki-style cancer CPGs, coordinated by a well-funded development body, along with incorporation of recommendations into point-of-care decision support would potentially address many of the issues identified.
Determinants of hypertension among diabetes patients attending selected comprehensive specialized hospitals of the Amhara Region, Ethiopia: An unmatched case-control study
Authors: Belew Makda Abate , Abate Teshager Woldegiorgis , Berhie Alemshet Yirga , Abeje Eleni Dagnaw , Ayele Dawit Algaw , Abate Melsew Dagne , Getu Rediet Akele , Bantie Berihun , Workie Sewnet Getaye 
Published: December 2022

BackgroundThe coexistence of diabetes mellitus and hypertension is a worldwide public health problem causing significant morbidity, mortality, and decreased quality of life. Despite the increasing burden of hypertension among patients with DM, data on determinants of hypertension among patients with DM in the Amhara region of Ethiopia is scarce. Hence, this study identified determinants of hypertension among people with diabetes attending chronic disease follow-up clinics in the Amhara region of comprehensive specialized hospitals in Ethiopia.Method and materialsAn institutional-based unmatched case-control study was conducted among 470 individuals with diabetes in the Amhara region’s comprehensive specialized hospitals (Debre Berhan, Felege Hiwot, and Dessie Comprehensive specialized hospital). A multistage sampling technique was used to select participants for this study. We collected the data using standard questionnaires (short form of international physical activity questionnaire, Morisky medication adherence scale, patient health questionnaire, perceived dietary adherence scale, Oslo social support questionnaire, and alcohol use disorder identification test), physical measurements, and data extraction checklists. A multivariable binary logistic regression was fitted to identify determinants of hypertension, and we presented the findings using an adjusted odds ratio (AOR) with a 95% confidence interval (CI).Results235 cases and 235 controls participated in this study. The median (IQR) age for the cases was 60 (52–66 = 14), and the mean age (± SD) for the controls was 51.72 (± 12.51). The significant determinants of hypertension with AOR [95% CI] were a lower level of physical activity: 1.82 [1.00, 3.31], depression: 2.00 [1.24, 3.21], family history of hypertension: 2.13 [1.34, 3.37], not having diabetic health education: 1.87 [1.18, 2.96], a longer duration of diabetes: 1.99 [1.05, 3.79], and poor glycemic control: 1.57 [1.01, 2.45].ConclusionIn this study, determinants that increase the risk of hypertension among people with diabetes mellitus were older age, physical inactivity, depression, family history of hypertension, not having diabetic health education, a longer duration of diabetes, and poor glycemic control.