bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypo-Hydroxymethylation of Nobox is Associated with Ovarian Dysfunction in Rat Offspring Exposed to Prenatal Hypoxia
Authors: Yao Changfang , Lu Likui , Ji Yiting , Zhang Yingying , Li Weisheng , Shi Yajun , Liu Jinliu , Sun Miao , Xia Fei 
Published: March 2022

AbstractPrenatal hypoxia (PH) is a common feature of a suboptimal intrauterine environment affecting the development of fetuses. Whether PH leads to abnormal ovary development is not yet clear. This study investigated ovarian function in offspring exposed to PH and the potential underlying molecular mechanisms. SD female rats (n = 12 per group) at 9 weeks of age were housed in individual cages (21% O2). After the pregnant rats were exposed to hypoxia (10.5% oxygen) from embryonic day (E) 5 to E21, PH offspring were generated. All animals maintained normoxia during lactation. The number of follicles was counted in female offspring at 3 months under an optical microscope. The expression of Nobox, Gdf9, and Tets was detected by quantitative real-time polymerase chain reaction (PCR) and Western blot. Global DNA hydroxymethylation was measured by dot blot. The hydroxymethylation level of the Nobox gene was evaluated with an NGS-based multiple targeted CpG hydroxymethylation analysis method. Body weight and ovary weight were significantly decreased in the PH group compared with the control group. PH offspring have abnormal estrous cycle, decreased serum anti-Mullerian hormone (AMH), and increased serum follicle-stimulating hormone (FSH), and follicular atresia, which are consistent with the clinical manifestations in patients with ovarian dysfunction. In terms of mechanism, the expression of Nobox was significantly decreased in the PH group. Subsequent high-throughput sequencing results showed that the level of hydroxymethylation in the candidate region of the Nobox gene was reduced. Cultured cells treated with hypoxia exhibited lower levels of both 5hmC and Nobox, while vitamin C, a coactivator of Tets, rescued hypo-hydroxymethylation and increased the expression level of Nobox. This study indicated that PH could cause hypo-hydroxymethylation of Nobox through epigenetic regulation and may consequently contribute to ovarian dysfunction in adult rat offspring.
On the Genealogy of Modality: The Necessity of Origin and the Origin of Necessity
Authors: BALLARIN ROBERTA 
Published: March 2022

ABSTRACTIn this article I contrast two opposing forms of essentialism, definitional and transcendental versus productivist and historical, and trace both forms back to Kripke's Naming and Necessity (1980). Definitional essentialism, as developed by Fine, centers on kind-membership. Historical essentialism, as anticipated by Prior and developed by Almog, puts origin at its center. The article focuses on the fundamentally distinct manners in which these two views handle the necessity of origin thesis. In the final section of the article, inspired by a Nietzschean genealogical methodology, I pursue a naturalization strategy and conclude that rather than origin being necessary, it is essentialist necessity that reduces to origin.
A complete clinico-epidemiological and microbiological profile of candidemia cases in a tertiary-care hospital in Western India
Authors: Rajni Ekadashi , Chaudhary Preeti , Garg Vishnu Kumar , Sharma Rajani , Malik Manisha 
Published: March 2022

Abstract

Objective:
To identify different Candida spp along with antifungal susceptibility pattern and risk factors associated with candidemia.

Design, setting, and patients:
This retrospective observational study was conducted in a tertiary-care academic hospital in Jaipur, Western India, for 3 years (July 2017–June 2020).

Methods:
Blood cultures were performed according to standard microbiological methods, and only 1 isolate per patient was included in the study. Isolates of Candida spp were identified using a VITEK-2 automated system and matrix-assisted laser desorption ionization-time of flight mass spectrometry. Antifungal susceptibility tests were performed using the broth microdilution assay according to the Clinical and Laboratory Standards Institute guidelines.

Results:
Of 3,443 blood cultures received from suspected sepsis cases, candidemia was identified in 95 (2.8%). In addition to Candida tropicalis (n = 36; 38%) and Candida parapsilosis (n = 17; 18%), 10 isolates of Candida auris comprised the fourth most common cause of candidemia. Presence of central venous catheter and diabetes were statistically significant risk factors for development of candidemia by NAC. Resistance to fluconazole was 36%, resistance to voriconazole was 20%, resistance to 5-flucytosine was 4%, and resistance to amphotericin-B was 7%. C. auris isolates were more resistant than other NAC spp. We detected no resistance among the echinocandins.

Conclusions:
The emergence of highly resistant isolates like C. auris emphasizes the need for constant monitoring of candidemia cases for species identification and routine antifungal susceptibility so that appropriate measures can be taken to reduce the related morbidity and mortality.
Women's personal networks and recourse to prenatal care in Bamako
Authors: Cisse Siaka , Rossier Clémentine , Sauvain-Dugerdil Claudine 
Published: March 2022

AbstractThis study aims to determine the role played by the personal networks of mothers aged 25–40 in Bamako (Mali) in their recourse to prenatal care. Although education and household's economic situation remain important, our research shows that personal network matters in two ways. Prenatal follow-up is more adequate in small, dense, less centralized networks, a structure known to generating a higher level of bonding social capital and mutual support. Yet, the composition of networks is also important: those comprising the husband and neighbors/friends—without other family members—are associated with better prenatal care. In these more open networks, women are probably less subject to traditional social control. An unexpected outcome is that material support does not play a significative role; this may indicate that more specific measures are needed to identify the type of support useful, or that, in this context, normative aspects are more important.
Virtual coercion and the vulnerable consumer: ‘loot boxes’ as aggressive commercial practices
Authors: Cartwright Peter , Hyde Richard 
Published: March 2022

AbstractLoot boxes have recently become a game mechanism of concern to policy-makers and regulators. The similarity between loot boxes and gambling is clear, and loot boxes and their regulation are commonly viewed through the lens of gambling. By contrast, very little attention has been given to tackling them as unfair, and in particular aggressive, commercial practices under consumer law. This article argues that by classifying the provision of loot boxes as a potentially aggressive commercial practice we will see that consumer law may protect gamers from some of the significant harms with which such products are associated.
Serum S100B protein after electroconvulsive therapy in patients with depression
Authors: Gbyl Krzysztof , Jørgensen Niklas Rye , Videbech Poul 
Published: March 2022

AbstractObjective:S100B is a glial cell protein with bimodal function. In low concentrations, it exerts neurotrophic effects, but higher levels reflect neuronal distress. Recent research suggests that this molecule may be a biomarker of response to electroconvulsive therapy (ECT). We examined the effect of ECT on serum S100B and its utility as 1) a biomarker of a depressive state and 2) a predictor of ECT response. We also wanted to ensure that ECT does not cause a marked serum S100B elevation, indicating neural distress.Methods:We measured serum S100B in 22 in-patients treated with ECT due to depression. Depression severity was assessed using 17-item Hamilton Rating Scale for Depression (HAMD-17). The data were collected before an ECT series, within 1 week after the series (post-ECT), and at a 6-month follow-up. Changes in serum S100B and clinical outcomes were tested using a linear mixed model. A relationship between serum S100B and the clinical outcomes was examined using Spearman’s and partial correlation.Results:Serum S100B did not change significantly immediately after an ECT series or 6 months later. The post-ECT serum S100B change was not associated with the clinical effect (rho = 0.14, n = 22, p = 0.54). The baseline serum S100B did not predict the clinical effect when controlling for age (r = 0.02, n = 22, df = 19, p = 0.92).Conclusion:The study neither supports serum S100B as a state marker of depression nor a predictor of ECT response. No evidence for ECT-related neural distress was found.
Attribute Agenda Setting on Twitter and theWall Street Journal: The Case of Congresswoman Ilhan Omar
Authors: Alkazemi Mariam , Oladi Ghadikolai Sameneh , Oetjens Marilynn , Boone Edward L. 
Published: March 2022

AbstractThis study examines attributes associated with U.S. Congresswoman Ilhan Omar. Omar's unique intersectionality of identities as a Black, immigrant, Muslim woman presents a rich case study for an examination of attribute agenda setting. A sample of Tweets, all Wall Street Journal articles referencing the congresswoman, and Google searches were obtained for the hashtags (“IlhanOmar,” “GoBack,” and “WelcomeHome.”) from May 2019 to January 2020. The Tweets and articles were then coded for a variety of dimensions. Analysis of the frequencies of words associated with the coding and the hashtags showed that the majority of the messages were negative despite the hashtag for which they were collected. A cross-correlation time series analysis showed that articles and editorials published by the Wall Street Journal predicted spikes in Google searches and Twitter messages. This article pinpoints underlying sociological phenomena about the representations of gender, race, religion, and immigration status to show the arguments that link attributes of Ilhan Omar together on Twitter.
Middle East Studies Under Occupation: The Case of Washington, D.C.
Authors: Sherman Corey 
Published: March 2022

AbstractA key component of Middle East Studies methodology is to identify and deconstruct the relationship between knowledge about the region and the power structures that give knowledge meaning. Typically, that methodology is applied to Middle East Studies at the post-secondary level. This paper applies that methodology to public schools in Washington, D.C. Through structural analysis, I will tease out the “epistemological commitments” (Abu El Haj 2001) of what the government of Washington, D.C. calls “social studies learning standards” -- short sentences which “detail the knowledge students are expected to acquire at a particular grade level.” Based on my experience teaching the Middle East in a Washington, D.C. public high school, I also raise questions about the relationship between the content standards and teachers’ work conditions, and whether such conditions support or inhibit the development of a praxis (Freire 2016) which could deconstruct US colonialism inside American public schools. One goal of this paper is to bring Middle East Studies into conversation with American Studies, broadly defined, and in particular ethnographic studies of DC that consider the colonial relationship between the US Government and Washingtonians. I conclude by calling for a deeper engagement with the American public school system by Middle East Studies scholars at both a theoretical and practical level
Studying Turkey through a Graphic Lens
Authors: Singer Amy , Martin Chris 
Published: March 2022

AbstractIn Turkish Kaleidoscope, social anthropologist and novelist Jenny White has expanded her repertoire to the graphic novel format to create an account of the violence and political chaos that pervaded Turkey in the late 1970s.2 White builds here on her academic work and her own student experience at Hacettepe University in Ankara. Artist Ergün Gündüz has created visual interpretations of place, space, events, and emotions that bring the story to life. This review is a collaborative class exercise for “Turkey: From Atatürk to Erdoğan” at Brandeis University in the Spring 2021 semester. It reflects on the novel as a text for Turkish history; the format of the work; the aesthetic choices of artist and author; and the experience of encountering this work in the contemporary historical moment. The review incorporates student comments as direct quotations. It was co-authored by Chris Martin, a student in the course.
Poor performance of predictive equations to estimate resting energy expenditure in patients with Crohn’s disease
Authors: Karachaliou Alexandra , Anastasiou Costas , Bletsa Maria , Mantzaris Gerassimos J. , Archavlis Emmanuel , Karampekos George , Tzouvala Maria , Zacharopoulou Eirini , Veimou Chrysoula , Bamias Giorgos , Kontogianni Meropi 
Published: March 2022

AbstractStudies exploring the accuracy of equations calculating resting energy expenditure (REE) in patients with Crohn’s disease (CD) are lacking. The aim of this study was to investigate the accuracy of REE predictive equations against indirect calorimetry in CD patients. REE was measured using indirect calorimetry (mREE) after an overnight fasting. Fourteen predictive equations, with and without body composition analysis parameters, were compared with mREE using different body weight approaches. Body composition analysis was performed using dual X-ray absorptiometry. One hundred and eighty-six CD outpatients (102 males) with mean age 41·3 (sd 14·1) years and 37·6 % with active disease were evaluated. Mean mREE in the total sample was 7255 (sd 1854) kJ/day. All equations underpredicted REE and showed moderate correlations with mREE (Pearson’s r or Spearman’s rho 0·600–0·680 for current weight, all P-values < 0·001). Accuracy was low for all equations at the individual level (28–42 and 25–40 % for current and adjusted body weight, respectively, 19–33 % for equations including body composition parameters). At the group level, accuracy showed wide limits of agreement and proportional biases. Accuracy remained low when sample was studied according to disease activity, sex, BMI and medication use. All predictive equations underestimated REE and showed low accuracy. Indirect calorimetry remains the best method for estimating REE of patients with CD.
Auditing Revival: George Whitefield and Public Accounting in Colonial America
Authors: Beales Kristen 
Published: March 2022

AbstractThis article situates George Whitefield's accounting controversies of the 1740s in the local public accounting cultures of colonial America. It argues that Whitefield developed a novel “commercial theology” and funding strategy for his Georgia orphanage that he believed would allow God to shape every aspect of the institution. While Whitefield's published financial accounts initially provoked little commentary, his critics began to use accounting as an “impartial” tool to disprove the minister's theology. The bold theological claims and lack of institutional oversight embedded in Whitefield's accounts violated the norms of public accounting, and his critics stated that an independent audit was the only way to clear the minister's name. The audit worked, and the combination of Whitefield's experience managing a transatlantic institution and his accounting controversies caused the minister to change his commercial theology. This article uses Whitefield's accounting controversies to make two overarching arguments. First, it argues that religious institutions were key parts of the local public accounting systems that shaped the development of financial ethics in colonial America. Second, it argues that financial accounts both shaped and reflected the religious assumptions of the bookkeepers who produced them.
Migratory behaviour does not alter cophylogenetic congruence between avian hosts and their haemosporidian parasites
Authors: de Angeli Dutra Daniela , Fecchio Alan , Braga Érika Martins , Poulin Robert 
Published: March 2022

AbstractParasites display various degrees of host specificity, reflecting different coevolutionary histories with their hosts. Avian hosts follow multiple migration patterns representing short but also long distances. As parasites infecting migratory birds are subjected to multiple environmental and biotic changes through their flyways, migration may disrupt or strengthen cophylogenetic congruence between hosts and parasites. On the one hand, parasites might adapt to a single migratory host, evolving to cope with the specific challenges associated with the multiple habitats occupied by the host. On the other, as migrants can introduce parasites into new habitats, higher rates of host switching could also disrupt cophylogenetic patterns. We analysed whether migratory behaviour shapes avian haemosporidian parasite–host cophylogenetic congruence by testing if contributions of host–parasite links to overall congruence differ among resident and short-, variable- and long-distance migrants globally and within South America only. On both scales, we found significant overall cophylogenetic congruence by testing whether overall congruence differed between haemosporidian lineages and bird species. However, we found no difference in contribution towards congruence among links involving resident vs migratory hosts in both models. Thus, migratory behaviour neither weakens nor strengthens bird–haemosporidian cophylogenetic congruence, suggesting that other avian host traits are more influential in generating phylogenetic congruence in this host–parasite system.
The politics of (non-)knowledge at Europe's borders: Errors, fakes, and subjectivity
Authors: Aradau Claudia , Perret Sarah 
Published: March 2022

AbstractFrom statistical calculations to psychological knowledge, from profiling to scenario planning, and from biometric data to predictive algorithms, International Relations scholars have shed light on the multiple forms of knowledge deployed in the governing of populations and their political effects. Recent scholarship in critical border and security studies has drawn attention to ‘the other side of knowledge’ and has developed a vibrant conversation with the emergent interdisciplinary field of ignorance studies. This article proposes to advance these conversations on governing through non-knowledge by nuancing the analysis of power/(non-)knowledge/subjectivity relations. Firstly, we expand the analysis of non-knowledge by attending to the problematisation of errors and fakes in controversies at Europe's borders. Errors have emerged in relation to border actors’ practices and technologies, while migrant practices, documentation, and narratives are deemed to be potentially ‘fake’, ‘fraudulent’, or ‘false’. Secondly, we explore how different subjectivities are produced through regimes of error/truth and fake/authenticity. We argue that there are important epistemic differences between ‘fake’ and ‘error’, that they are entangled with different techniques of power and produce highly differentiated subjectivities. Finally, we attend to how these subjectivities are enacted within racialised hierarchies and ask whether non-knowledge can be mobilised to challenge these hierarchies.
From Many Divides, One? The Polarization and Nationalization of American State Party Platforms, 1918–2017
Authors: Hopkins Daniel J. , Schickler Eric , Azizi David L. 
Published: March 2022

AbstractMany contend that U.S. state parties are increasingly polarized and nationalized, meaning that they have adopted divergent positions matching their national counterparts’ positions. Such trends reflect a transformation of America's historically decentralized party system. Yet, the precise timing of these related trends—as well as the mechanisms underpinning them—remain unclear. We assess these dynamics using a novel data set of 1,783 state party platforms between 1918 and 2017. Applying tools from automated and manual content analysis, we document a dramatic divergence in the topics emphasized by Democrats and Republicans starting in the mid-1990s, just as congressional speech became polarized. During this period, cross-state differences in each party's agenda decreased and regional/sectoral issues became less prominent, suggesting tight connections between polarization, nationalization, and state agendas. We also find that innovative phrases increasingly debut in state (not national) platforms. Overall, the evidence undercuts claims of top-down polarization emanating from national party leaders in Washington, DC. Polarization at the state and federal levels coincided with the development of an integrated network of activists spanning multiple levels of the polity.
How the ARCH Project Could Contribute to Strengthening ASEAN Regional Capacities on Disaster Health Management (DHM)
Authors: Wuthisuthimethawee Prasit , Satthaphong Supalerk , Phongphuttha Weerasak , Sarathep Prakit , Piyasuwankul Thammapad , Công Sinh N. , Đúc Chính N. , Nhu’ Lâm N. , Văn Nhu’ H. , Feliciano Janice P. , Danac Alfonso C. , Ariani Madelina , Donna Bella , Isturini Ina A. , Saelim Phummarin , Pintatham Kriangsak , Thepmanee Duangpon , Silapunt Phumin , Limpaporn Sansana , Yuddhasaraprasiddhi Kittima , Promkhum Dangfun , Ikeda Shuichi 
Published: March 2022

AbstractObjective:The Project for Strengthening the ASEAN Regional Capacity on Disaster Health Management (ARCH Project) developed Regional Collaboration Drills (RCDs) and is proposing an ASEAN Academic Network to strengthen capacity in disaster health management (DHM) in ASEAN Member States (AMS), as well as developing a standard training curriculum in DHM. This study aims to clarify the impacts and sustainability of the ARCH Project.Methods:The four previous RCDs and the enhancement of academic activities were reviewed.Results:The ARCH Project developed the RCDs with simulation exercises based on possible disaster scenarios in each host country to test and validate the capacity of AMS International Emergency Medical Teams (I-EMTs), the Standard Operating Procedure (SOP) for I-EMT coordination, and regional tools, as well as the relevant domestic SOPs of the host countries for receiving international assistance. Following the RCD in Thailand, three AMS: Viet Nam, Philippines, and Indonesia, all of which are considered disaster-prone, successfully hosted RCDs with significant improvements. The project also established a sub-working group (SWG) to develop a standard curriculum in DHM. Two curricula developments, the Basic Course on DHM and In-Country Course for Coordination on EMTs, are on-going as part of the project activity. The establishment of the ASEAN Academic Network and the ASEAN Institute for DHM (AIDHM) are currently in the endorsement process of the ASEAN health sector.Conclusion:
The RCDs are very effective to test and to validate the SOP and regional tools developed, providing opportunities for AMS I-EMT to familiarize the tools, as well as for host countries to assess their coordination capacity for receiving international assistance and identifying the country’s specific challenges, and verifying ASEAN regional coordination mechanism. The development of the standard curriculum can enhance regional capacity both in supporting disaster-affected countries and in receiving international assistance. A sustainable capacity development mechanism in DHM is envisaged through the establishment of the ASEAN Academic Network and AIDHM toward the goal of One ASEAN One Response.