bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resistance to fracture of simulated external cervical resorption cavities repaired with different materials
Authors: Arıcan Burçin , Sesen Uslu Yesim , Sarıalioğlu Güngör Ayça 
Published: November 2022

AbstractThe aim of the study was to evaluate the fracture resistance (FR) of teeth with simulated external cervical resorption (ECR) cavities repaired with different materials. Following the shaping of the 80 human permanent maxillary central incisors, standard ECR cavities were prepared and restored with a nanohybrid composite resin; a high viscosity GIC Equia Forte Fill; Biodentine; Biodentine + nanohybrid composite resin; MTA BIOREP; MTA BIOREP + nanohybrid composite resin. Then, the root canals were obturated with AH Plus and gutta‐percha. The roots were embedded acrylic resin blocks and fracture strength test was applied. The highest FR was observed in the Biodentine group, while the lowest was in Equia group (p < 0.05). No significant results were observed among composite, Biodentine + composite, MTA BIOREP + composite and MTA BIOREP (p > 0.05). Biodentine may be a preferable material for repairing ECR cavities. Adding a composite layer on MTA BIOREP and Biodentine did not improve the FR of these materials.
What is free food worth? A nonmarket valuation approach to estimating the welfare effects of food pantry services
Authors: Byrne Anne T. , Just David R. 
Published: November 2022

AbstractFood pantries provide groceries to millions of households in the United States every year. Although there is research and information on many other aspects of food pantries, including financial information such as tax valuations for donated food, there is not a literature establishing the economic value of food pantry access for clients and potential clients. We use a valuation approach from environmental economics, revealed preference travel cost modeling, in a novel application to estimate food pantry value. We use a rich administrative dataset from a food bank system in Colorado and estimate demand for pantry visits, exploiting the move of a local pantry to correct for endogeneity bias. We find that the annual value of pantry access to pantry client households is between $600 and $1000, and the value per pantry visit is between $40 and $60. If we assume these values hold nationally, our localized results imply that the collective value of food pantry access among pantry client households may be between $19 billion and $28 billion dollars annually.
The impact of rural nursing and midwifery clinical placements from the perspective of health service staff
Authors: Walker Clara , Forbes Roma 
Published: November 2022

AbstractObjectiveTo explore the impact of providing nursing and midwifery student placements from the perspective of regional, rural and remote health service staff involved in hosting students.SettingHospital and health services across regional, rural and remote southern Queensland.ParticipantsThirty‐six nursing and midwifery staff working in clinical and/or management roles who were direct clinical supervisors of students or in leadership positions with responsibility for overseeing and supporting clinical placements.DesignSemi‐structured interviews exploring the experiences and perspectives of nursing and midwifery health service staff who support student placements. Data were subject to thematic analysis.ResultsFive key themes were identified as follows: (a) bringing new ideas and perspectives, (b) opportunities for development, (c) supporting the future rural workforce (d) impacts on workload and productivity and (e) strategies for balancing supervision.ConclusionThe results indicate that there are a range of perceived benefits and challenges of providing nursing and midwifery student placements within regional, rural and remote settings. The findings also indicate that there are opportunities to further support rural health services to optimise the positive impacts and mitigate the challenges of providing placements. To do so requires collaboration between health services and education providers to allocate students appropriately to health services and support health service staff.
Characterisation of children and adolescents with acute lymphoblastic leukaemia who presented without peripheral blood blasts at diagnosis
Authors: Mangum David Spencer , Bishop Johnathon D. , Zhou Yinmei , Cheng Cheng , Karol Seth E. , Rubnitz Jeffrey E. , Ribeiro Raul C. , Yang Jun J. , Mullighan Charles G. , Jeha Sima , Pui Ching‐Hon , Inaba Hiroto 
Published: November 2022

SummaryOf 1003 children with acute lymphoblastic leukaemia (ALL), 147 (14.7%) presented without peripheral blood blasts (PBB). While absence of PBB was not independently associated with survival outcomes when compared to those with PBB, patients without PBB had distinct genetic and clinical characteristics. Notably, we identified a novel genotype–phenotype relationship, in that the patients without PBB had a significantly higher incidence of hyperdiploid B‐ALL, accounting for almost half of all patients without PBB (46.9% vs. 22.7%, p < 0.001). Further, absence of PBB was associated with decreased rates of leukaemia involvement of the central nervous system (p < 0.001).
Septin 9 controls CCNB1 stabilization via APC/CCDC20 during meiotic metaphase I/anaphase I transition in mouse oocytes
Authors: Chen Li , Ouyang Ying‐Chun , Gu Lin‐Jian , Guo Jia‐Ni , Han Zhi‐Ming , Wang Zhen‐Bo , Hou Yi , Schatten Heide , Sun Qing‐Yuan 
Published: November 2022

AbstractThe anaphase promoting complex/cyclosome (APC/C) and its cofactors CDH1 and CDC20 regulate the accumulation/degradation of CCNB1 during mouse oocyte meiotic maturation. Generally, the CCNB1 degradation mediated by APC/CCDC20 activity is essential for the transition from metaphase to anaphase. Here, by using siRNA and mRNA microinjection, as well as time‐lapse live imaging, we showed that Septin 9, which mediates the binding of septins to microtubules, is critical for oocyte meiotic cell cycle progression. The oocytes were arrested at the MI stage and the connection between chromosome kinetochores and spindle microtubules was disrupted after Septin 9 depletion. As it is well known that spindle assembly checkpoint (SAC) is an important regulator of the MI‐AI transition, we thus detected the SAC activity and the expression of CDC20 and CCNB1 which were the downstream proteins of SAC during this critical period. The signals of Mad1 and BubR1 still remained on the kinetochores of chromosomes in Septin 9 siRNA oocytes at 9.5 h of in vitro culture when most control oocytes entered anaphase I. The expression of CCNB1 did not decrease and the expression of CDC20 did not increase at 9.5 h in Septin 9 siRNA oocytes. Microinjection of mRNA encoding Septin 9 or CDC20 could partially rescue MI arrest caused by Septin 9 siRNA. These results suggest that Septin 9 is required for meiotic MI‐AI transition by regulating the kinetochore‐microtubule connection and SAC protein localization on kinetochores, whose effects are transmitted to APC/CCDC20 activity and CCNB1 degradation in mouse oocytes.
S2k Guideline for the diagnosis and treatment of mucous membrane pemphigoid
Authors: Hofmann Silke C. , Günther Claudia , Böckle Barbara C. , Didona Dario , Ehrchen Jan , Gaskins Matthew , Geerling Gerd , Gläser Regine , Hadaschik Eva , Hampl Monika , Haßkamp Pia , Jackowski Jochen , Kiritsi Dimitra , Nast Alexander , Pleyer Uwe , Reichel Christoph , Roth Mathias , Schumann Michael , Sticherling Michael , Worm Margitta , Zillikens Detlef , Goebeler Matthias , Schmidt Enno 
Published: November 2022

SummaryMucous membrane pemphigoid (MMP) is a pemphigoid disease with predominant mucous membrane involvement. It mainly affects the mucous membranes of the mouth, eyes, nose and pharynx, but also the larynx, trachea, esophagus, genital and perianal regions. The manifestation of the disease covers a wide spectrum from gingival erythema and single oral lesions to severe tracheal strictures that obstruct breathing and conjunctival scarring with marked visual impairment and, not infrequently, blindness. In addition to a clinical picture of predominant mucosal involvement, diagnosis is based on direct immunofluorescence of a peri‐lesional biopsy and serology. The main target antigen is BP180 (collagen XVII), and reactivity with laminin 332 is associated with malignancy in approximately 25 % of MMP patients. The treatment of MMP is challenging. On the one hand, due to the involvement of different mucous membranes, good interdisciplinary cooperation is required; on the other hand, due to the rarity of the disease, no randomized controlled clinical trials are available. The aim of this guideline is to present the clinical picture, including severity and scoring systems, and to give guidance for diagnosing and treating this complex disease. In MMP, interdisciplinary cooperation plays an essential role as well as the prompt diagnosis and initiation of adequate therapy in order to avoid irreversible damage to the mucous membranes with serious complications.
Transcatheter mitral valve repair in a liver transplant candidate
Authors: Ates Ismail , Mutlu Deniz , Inanc Ibrahim Halil , Marmagkiolis Konstantinos , Iliescu Cezar A. , Kilic Ismail Dogu , Cilingiroglu Mehmet 
Published: November 2022

AbstractUntreated severe mitral regurgitation (MR) is associated with poor outcomes due to the adverse consequences of long‐standing volume overload on the left ventricle and left atrium, which leads to pulmonary hypertension and right‐sided heart failure. Early intervention results in favorable long‐term outcomes making appropriate timing of intervention very critical. We present a 53‐year‐old male with severe symptomatic MR and right sided‐heart failure which progressed to cardiac cirrhosis necessitating enrollment to the liver transplant list. Transcatheter mitral valve repair (TMVR) using MitraClip implantation resulted in impressive clinical improvement and resolution of cirrhosis. Eventually, the patient was taken off the transplant list. Treatment of severe MR may lead to improvements in congestive hepatopathy.
MNK/eIF4E inhibition overcomes anlotinib resistance in non‐small cell lung cancer
Authors: Zhang Qi , Li Hui , Li Quan , Hu Qiyan , Liu Bo 
Published: November 2022

AbstractAnlotinib is approved for refractory cases in advanced non‐small‐cell lung cancer (NSCLC). This is a novel oral multitarget tyrosine kinase inhibitor, but patients inevitably face prospects of drug resistance during the treatment process. Using anlotinib‐resistant NSCLC models, this work investigated the underlying molecular mechanism and systematically addressed the issue of anlotinib resistance. We demonstrated that expression and activity of eukaryotic translation initiation factor 4E (eIF4E) were upregulated in NSCLC cells due to prolonged exposure to anlotinib. eIF4E depletion resulted in significant effects to anlotinib‐resistant cells, showing proliferation inhibition and apoptosis inducement. We further showed that MAP kinase interacting serine/threonine kinase (MNK)‐dependent eIF4E inhibition by cercosporamide was active against anlotinib‐resistant cells and significantly augmented anlotinib's efficacy in parental NSCLC cells. Importantly, observations from in‐vitro experiments are consistent in in vivo anlotinib‐resistant and anlotinib‐sensitive NSCLC cancer xenograft mouse models. Our work is the first to reveal that eIF4E is involved intimately in anlotinib resistance development in NSCLC, and this eIF4E activation can be reversed by cercosporamide or other MNK inhibitors.
Effect of interface roughness on fracture energy and fracture process zone of rock‐concrete specimens
Authors: Guo Yuzhu , Chen Xudong , Liu Jixuan , Chen Tao , Wu Jin 
Published: November 2022

AbstractTo investigate the effect of interface roughness on the fracture behaviors of rock‐concrete specimens, the acoustic emission (AE) and digital image correlation (DIC) techniques are used to monitor the fracture process of the granite‐concrete specimens with different interfacial roughnesses under three‐point bending (TPB) load. The initial fracture toughness of rock‐concrete specimens with different interfacial roughnesses is calculated. The characteristic parameters of the AE are also discussed. Based on the fracture mechanics theory, the transient critical response equation and the stress‐crack opening displacement model for the rock‐concrete interface crack opening displacement (COD) based on micro–macro crack interactions are established. The determination of the model parameters is achieved by the DIC technique, and the fracture energies of interfaces with different roughnesses are calculated based on the model with the determined parameters. The validity of the model is verified by comparing the calculation results with those from the existing fracture energy calculation methods.
Infra‐ and labio‐position of two maxillary central incisor implants in an older adult at a 17‐year follow‐up
Authors: Park Won‐Bae , Han Ji‐Young , Thoma Daniel S. , Herr Yeek , Lim Hyun‐Chang 
Published: November 2022

AbstractObjectiveThis report aims to present an infra‐ and labio‐version of the implants relative to the surrounding teeth in an older patient.BackgroundInfra‐positioning of dental implants has been sometimes observed in young adults but not in older patients.Materials and methodsTwo implants were placed in both central incisor areas in a 63‐year‐old female patient in 2002. A splinted implant prosthesis was inserted six months later.ResultsAfter 17 years, a deviation in the position of the implant crown on the #21 area was 9.94 mm labially and 4.69 mm apically with respect to the adjacent tooth (#22). The corresponding values of the implant crown on the #11 area were 5.96 and 2.34 mm (with respect to #12), respectively.ConclusionDental implants in older adults might develop horizontal and vertical discrepancies relative to the neighbouring teeth.
Associations between salivary testosterone levels and cognitive function among 70‐year‐old Japanese elderly: A cross‐sectional analysis of the SONIC study
Authors: Hirokawa Kumi , Kasuga Ayaka , Matsumoto Kiyoaki , Omori Yasuko , Masui Yukie , Nakagawa Takeshi , Ogawa Madoka , Ishioka Yoshiko , Inagaki Hiroki , Ikebe Kazunori , Arai Yasumichi , Ishizaki Tatsuro , Kamide Kei , Gondo Yasuyuki 
Published: November 2022

AimThis cross‐sectional study aimed to investigate the associations between salivary testosterone concentrations and cognitive function in 70‐year‐old Japanese elderly people without dementia and stroke.MethodsParticipants were 197 Japanese community‐dwelling people aged 69–71 years. Their salivary samples were collected, and their cognitive function was assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA‐J). Participants were also administered a 10‐item recall and a 24‐item recognition test. The data for 179 (106 men and 73 women) individuals were analyzed, excluding individuals with a past history of stroke and dementia. Multivariate logistic regression analyses were performed after adjusting for lifestyle factors and analyzing data separately for men and women.ResultsMoCA‐J scores showed that men with low testosterone concentrations had a significantly greater risk of low cognitive performance than those with high testosterone concentrations (adjusted odds ratio: 4.72, 95% confidence interval: 1.06–21.00), while no significant association was found in women. The 10‐item recall test scores showed that higher testosterone concentrations were significantly associated with greater recall in the second trial in women (standardized beta = 0.24, P = 0.040), whereas no significant association was found in men. Salivary testosterone concentrations were positively associated with better cognitive performance in older men and women.ConclusionsThe associations between salivary testosterone concentrations and cognitive function were shown by different tasks for men and women. Geriatr Gerontol Int 2022; 22: 1040–1046.
Spatial differentiation and factors influencing the benefits of industrial poverty alleviation in villages
Authors: He Tian , Chen Rui Yuan , Wang Zi Yi , Sun Ping Jun , Shi Man Jiang , Xiong Lin , Liu Yuan Li , Liao He Ping 
Published: November 2022

AbstractIndustrial poverty alleviation is one of the most important aspects of targeted poverty alleviation. Identifying the mechanism influencing the spatial differentiation of the benefits of industrial poverty alleviation plays an essential role in optimising an industrial layout for poverty alleviation, consolidating poverty alleviation achievements, and revitalising rural industries. This study examined the spatial distribution characteristics and influencing factors of the benefits of industrial poverty alleviation at the village level using the household data collected from Jiangjin District, Chongqing, China. The results show that the benefits of industrial poverty alleviation presented obvious spatial differentiation in the villages with the overall performance being high in the north and low in the south and decreasing from the south of the county to the north and south. Spatially, there was a significant positively correlated agglomeration effect. High‐value agglomeration areas were concentrated in the north with the characteristics of ‘one centre and two subcentres’. However, low‐value and outlier agglomeration effects were not obvious, presenting sporadic distribution. Seven major factors affect industrial poverty alleviation in Jiangjin District, including average altitude and land transfer rate. The interaction between any two of the seven factors has a more significant impact than that of a single factor.
The usefulness of a newly developed full‐core biopsy needle in liver biopsy
Authors: Takeuchi Hirohito , Sugimoto Katsutoshi , Kakegawa Tatsuya , Tomita Yusuke , Takahashi Hiroshi , Wada Takuya , Abe Masakazu , Yoshimasu Yu , Matsubayashi Jun , Nagao Toshitaka , Itoi Takao 
Published: November 2022

AbstractAimTo evaluate the usefulness and safety of a newly developed full‐core biopsy needle.MethodsWe selected 149 patients who underwent percutaneous liver biopsy at our institution from February 2019 to April 2021. We excluded 35 patients with hepatic fibrosis stage F3 or higher, which made it histopathologically difficult to measure the number of complete portal triads. The patients were divided into two groups as follows: 62 cases with the 18‐G conventional automated needle (TruCore needle: T needle), and 52 cases with the 18‐G full‐core needle (CorVocet needle: C needle). We measured the number of complete portal triads in the liver tissue specimens, and the sum of the length and width of the collected tissues. Moreover, we compared the number of session counts, fragmentations, and complications.ResultsThe sum of the length and the width was 12.8 mm (11.2–14.3) and 15.9 mm (13.1–17.3; p < 0.001), and 0.68 mm (0.63–0.74) and 0.82 mm (0.78–0.90; p < 0.001) for the T needle and C needle, respectively. The number of complete portal triads and fragmentation was six (3–8) and 10 (6–13; p < 0.001), and one (1–10) and one (1–3; p < 0.001), for the T needle and C needle, respectively. There was one session count (1–2) in both groups; however, there were significantly higher cases of two sessions with the T needle than that with the C needle (p = 0.018). There were no serious adverse events.ConclusionsCompared with the conventional needles, the newly developed full‐core needles enabled the acquisition of a larger amount of tissue sample in liver biopsy.
Clinical utility of nailfold capillaroscopy
Authors: Roberts‐Thomson Peter J. , Patterson Karen A. , Walker Jennifer G. 
Published: November 2022

AbstractNailfold capillaroscopy (NFC) is a simple noninvasive microscopic technique used to identify characteristic morphological abnormalities in the nailfold capillaries. The presence of this microvasculopathy appears to be of fundamental importance in the pathological processes that underlie the scleroderma spectrum disorders (including dermatomyositis and antisynthetase myositis). This review discusses the different methodologies and techniques in performing NFC and stresses the diagnostic utility achieved with simple ‘bedside’ techniques utilising the ophthalmoscope, dermatoscope or smart phone. Recent advances in reporting abnormal microvascular patterns and vascular metrics (e.g. capillary density and dropout) are discussed. The aetiopathogenesis of the microvasculopathy is currently unknown but its close association with Raynaud Phenomena and specific autoantibodies together with recent observations from sequential NFC allows speculations on its possible mechanism. Finally, future developments in the use of NFC as a possible biomarker in the management of the scleroderma spectrum disorders are discussed, with a recommendation that NFC becomes more widely available, particularly in rheumatological, immunological and dermatological practice. NFC provides a clinically accessible window on the pathologic process fundamental to scleroderma‐related disease.
Vegetation change on Mt. Teide, the Atlantic's highest volcano, inferred by incorporating the data underlying Humboldt'sTableau Physique des Iles Canaries
Authors: Renner Susanne S. , Otto Rüdiger , Martín‐Esquivel José Luis , Marrero‐Gómez Manuel V. , Fernández‐Palacios José María 
Published: November 2022

AbstractAimWe analyse the oldest available data on the high‐elevation vegetation on Tenerife's Mt. Teide, namely the species shown in A. von Humboldt's (1817)Tableau Physique des Iles Canaries(TPIC), which is based on his own 1799 visit and an 1815 visit by L. von Buch and C. Smith. The analysis is of interest in the context of climate change and biotic changes, such as the eradication of non‐native goats from the Teide National Park. Between 1944 and 2010, the summit region of Mt. Teide has warmed at a rate of 0.14°C/decade.LocationMt. Teide on Tenerife, Canary Islands.TaxonVascular plants.MethodsWe updated the taxonomy of the 197 species shown in the TPIC, data‐mined publications and letters, searched relevant herbaria for surviving collections, and compared historic and modern species presence, absence and elevational ranges.ResultsBoth Humboldt and Buch had to use formulas to convert barometer readings into elevations above sea level, and none of Humboldt's collections and few of Buch's are linked to precise elevations. The upper range limits of all 23 species for which we found data have shifted upward, with the average shift being 36.4 m per decade (1799/1815–2021). Four species that today are abundant were not recorded in 1815, suggesting population expansion, probably due to goat eradication.Main conclusionsWhile our data cannot disentangle the effects of climate change and changing herbivory, they provide the earliest available record on the vegetation on Mt. Teide and illustrate the magnitude of change.