bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uplink performance of nonorthogonal multiple access ultradense networks with power control
Authors: Cong Lam Sinh , Pham Thanh Hiep , Tran Xuan Nam 
Published: January 2022

SummaryThis paper studies power control in ultradense networks which are potential network models of 5G cellular systems. The power control model that bases on stretched path loss model (SPLM) is introduced to allow each user to proactively adjust its transmission power to adapt to power loss and network status. The moment‐generating function (MGF) is utilized through the paper to analyze the uplink coverage probability (UCP) in which it is assumed that the base station (BS) of interest does not have information about fast fading of interfering channels. The analytical results indicate that the proposed power control model can reduce user power consumption while maintaining the UCP. Two interesting facts have been stated when comparing the performance of the networks in good and bad channel conditions. First, the user equipment (UE) in bad channel conditions outperforms others in good channel conditions. Second, the deployment of nonorthogonal multiple access (NOMA) technique can significantly improve the area spectral efficiency (ASE) in bad channel conditions.
The glial cell’s role in antinociceptive differential effects of oxytocin upon female and male rats
Authors: Salinas‐Abarca Ana B. , Vázquez‐Cuevas Francisco G. , González‐Gallardo Adriana , Martínez‐Lorenzana Guadalupe , González‐Hernández Abimael , Condés‐Lara Miguel 
Published: January 2022

AbstractBackgroundSex plays a crucial role in pain processing and response to analgesic drugs. Indeed, spinal glia seems to be significant in the sexual dimorphism observed in the above effects. Recently, studies have associated oxytocin with antinociceptive effects, but these have been mainly performed in male animals; consequently, the influence of sex has been poorly explored. Methods: Using a model of spinal nociception that produces pain through activation of the spinal glia, that is, intrathecal (i.t.) lipopolysaccharide (LPS) injection, we analysed the changes in the analgesic response to i.t. oxytocin in female and male rats by behavioural (punctate mechanical hypersensitivity), electrophysiological (unitary extracellular recordings of wide dynamic range [WDR] cells) and molecular biology (real‐time PCR of proinflammatory genes) experiments.ResultsWe found that LPS‐induced hypersensitivity was longer in female (>96 h) than in male (≈4 h) rats. Besides, spinal oxytocin preferentially prevents the LPS‐induced hypersensitivity in male rather than female rats. Indeed, LPS increases the spinal neuronal‐evoked activity associated with the activation of peripheral Aδ‐ and C‐fibres and post‐discharge in males, whereas only C‐fibre discharge was enhanced in females. The electrophysiological data correlate with the fact that spinal oxytocin only prevented TNF‐α and IL‐1β synthesis in male rats.ConclusionsTherefore, these data suggest that oxytocin‐mediated analgesia depends on a sexual dimorphism involving activation of the spinal glia. These results reinforced the idea that different strategies are required to treat pain in men and women, and that oxytocin could be used preferentially to treat pain with a significant inflammatory component in men.Significance StatementOxytocin is a molecule that emerges as a potent analgesic in preclinical and clinical studies. We investigated the contribution of glia to the response of oxytocin‐induced analgesia and how sex influences in this response show that different strategies are required to treat pain in men and women, and that oxytocin could be used preferentially to treat pain with a significant inflammatory component in men.
Decadal‐scale impacts of changing mangrove extent on hydrodynamics and sediment transport in a quiescent, mesotidal estuary
Authors: Glover Hannah E. , Stokes Debra J. , Ogston Andrea S. , Bryan Karin R. , Pilditch Conrad A. 
Published: January 2022

AbstractMangroves are often considered integral engineers of morphologic evolution, but mangroves can also opportunistically respond to morphologic change created by abiotic sedimentary processes. Consequently, predicting the response of individual estuarine environments to changes in mangrove extent is challenging. Here, the impact of mangrove extent was explored using in‐situ observations and numerical modeling of the quiescent Waikaraka Estuary in Tauranga Harbor, Aotearoa, New Zealand. Mangrove coverage expanded in the estuary from 1940 until a removal program began in 2005 with the goal of reducing fine sediment and restoring bivalve habitat. In June 2019 water velocity, turbidity, wave height, and bed‐sediment grain size were measured at multiple sites to identify how sediment dynamics in the estuary were responding to removal. Flow in the predominantly sandy lower estuary was ebb dominant, resulting in net sediment export, while flow in the muddy upper estuary was weakly flood dominant, resulting in sediment import and retention. Therefore, fine sediment is unlikely to be flushed out of quiescent estuaries after mangrove removal. A Delft3D numerical model calibrated with in‐situ data showed that tidal asymmetry, velocity skew, and peak ebb‐tide shear stress were not significantly altered by varying the mangrove extent between the 2005 maximum coverage and complete removal. Mangroves did not significantly impact flow in this system; instead, the hydrodynamics and net sediment transport were controlled by tidal interactions with bathymetry. In model runs with mangroves covering all tidal flats, the water velocity on the intertidal flats decreased while the peak ebb‐tide velocity in the main channel increased, indicating that the potential for fine‐sediment export may actually decrease with mangrove removal. These results emphasize the role of mangroves as opportunistic colonizers, not engineers, and highlight the importance of considering site specific parameters when planning mangrove removals.
Initial morphological responses of coastal beaches to a mega offshore artificial island
Authors: Liu Gen , Qi Hongshuai , Cai Feng , Zhu Jun , Zhao Shaohua , Liu Jianhui , Lei Gang , Cao Chao , He Yanyu , Xiao Zheyu 
Published: January 2022

AbstractMega offshore artificial islands (MOAIs) can lead to large‐scale and significant coastal responses, which have been poorly documented. In this study, coastal changes of an 8 km‐long beach along Haikou Bay, China, were analysed to advance the understanding of the potential morphological responses to a MOAI with a diameter of 2.3 km. Field surveys of beach profiles and shorelines in different years were used to reveal the initial coastal changes after the construction of the MOAI. The results showed that the beach in the leeside of the MOAI accreted seaward, whereas the adjacent beaches retreated, which was revealed to be closely related to the alteration in longshore sediment transport patterns induced by the presence of the MOAI. As predicted by empirical equations, a large salient (hundreds of metres of amplitude) rather than a tombolo would be formed on the leeside of the MOAI if there is sufficient sediment supply. From the initial morphological observation, it was indicated that the final total beach length affected by this MOAI will be larger than 6200 m. However, based on predictive equations derived from small‐scale offshore obstacles (SCOOs), this value was less than 6200 m. It is likely that the geometric properties induced by MOAIs may not be estimated by these empirical equations derived from SCOOs. Moreover, a great difference in salient equilibrium time was highlighted between them. The timescale of salient equilibrium for this MOAI was likely on an order of hundred years of magnitude, while that for SCOOs were generally less than 10 years, which was related to the water depth of the obstacle position. This study provides new insights into the differences in coastal change between the MOAI and SCOOs and will help local governments adopt appropriate coastal sediment management strategies from a regional scale and a longer timescale in the face of increasing human activities.
Astrocyte‐targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and protects fast‐fatigable motor units in a mouse model of amyotrophic lateral sclerosis
Authors: Rochat Cylia , Bernard‐Marissal Nathalie , Källstig Emma , Pradervand Sylvain , Perrin Florence E. , Aebischer Patrick , Raoul Cédric , Schneider Bernard L. 
Published: January 2022

AbstractIn amyotrophic lateral sclerosis (ALS) caused by SOD1 gene mutations, both cell‐autonomous and noncell‐autonomous mechanisms lead to the selective degeneration of motoneurons (MN). Here, we evaluate the therapeutic potential of gene therapy targeting mutated SOD1 in mature astrocytes using mice expressing the mutated SOD1G93A protein. An AAV‐gfaABC1D vector encoding an artificial microRNA is used to deliver RNA interference against mutated SOD1 selectively in astrocytes. The treatment leads to the progressive rescue of neuromuscular junction occupancy, to the recovery of the compound muscle action potential in the gastrocnemius muscle, and significantly improves neuromuscular function. In the spinal cord, gene therapy targeting astrocytes protects a small pool of the most vulnerable fast‐fatigable MN until disease end stage. In the gastrocnemius muscle of the treated SOD1G93A mice, the fast‐twitch type IIB muscle fibers are preserved from atrophy. Axon collateral sprouting is observed together with muscle fiber type grouping indicative of denervation/reinnervation events. The transcriptome profiling of spinal cord MN shows changes in the expression levels of factors regulating the dynamics of microtubules. Gene therapy delivering RNA interference against mutated SOD1 in astrocytes protects fast‐fatigable motor units and thereby improves neuromuscular function in ALS mice.
Healing the degradable organic–inorganic heterointerface for highly efficient and stable organic solar cells
Authors: Tao Yangdan , Liu Haoran , Wang Di , Zhao Feng , Chen Zeng , Zhu Haiming , Chen Hongzheng , Li Chang‐Zhi 
Published: January 2022

AbstractThe heterointerface between the contacted organic and inorganic semiconductors critically affects the charge extraction, hence overall performance of organic optoelectronics, especially for organic solar cells (OSCs). Herein, we develop an effective interfacial strategy that simultaneously boosts the chemical, electric, and electronic properties of the organic–inorganic heterointerface of the derived OSCs, through implanting conjugated molecules as self‐assemble monolayers (SAMs) to metal oxide nanoparticles (MO NPs). As results, SAM passivated zinc oxide nanoparticles (ZnO NPs) as electron transport layers (ETLs) not only enable the best performed OSCs containing MO ETLs, but also exhibit the most desirable thickness insensitive features (up to 300 nm). In addition, SAM‐ZnO ETLs help also substantially improving the photostability of the derived OSCs. Overall, this work can be beneficial to the further development of high‐performance and cost‐effective OSCs.image
Silencing of circCDC14A prevents cerebral ischemia‐reperfusion injury via miR‐23a‐3p/CXCL12 axis
Authors: Huo Huiyi , Hu Chao , Lu Yongxue , Zhou Jinyu , Mai Zhiguang 
Published: January 2022

AbstractIschemic stroke is one of the main causes of death and disability. Circular RNAs (circRNAs) have received extensive attention in the pathogenesis of ischemic stroke. Here, we evaluated the role of circCDC14A in cerebral ischemia‐reperfusion (CI/R) injury in vivo and in vitro. The expression of circCDC14A was significantly upregulated in the middle cerebral artery occlusion (MCAO) model and oxygen and glucose deprivation/reoxygenation (OGD/R)‐treated HT22 cells. Knockdown of circCDC14A suppressed the cell viability reduction caused by OGD/R, as well as cell damage and apoptosis. Mechanistically, circCDC14A acted as a sponge for miR‐23a‐3p and promoted the expression of chemokine stromal‐derived factor‐1 (CXCL12) by negatively regulating miR‐23a‐3p. Rescue experiments further confirmed that miR‐23a‐3p inhibitor or circCDC14A‐overexpression vectors blocked the beneficial effects of circCDC14A knockdown in OGD/R‐induced HT22 cells. Moreover, knockdown of circCDC14A suppressed MCAO‐induced cerebral infarction and neurological damage, as well as the brain tissue damage and neuronal apoptosis in vivo. Consistently, miR‐23a‐3p antagomir treatment abolished the cerebral protective effects of circCDC14A knockdown on MCAO mice. In conclusion, circCDC14A promoted CI/R injury by regulating the miR‐23a‐3p/CXCL12 axis, which suggested that circCDC14A may become a potential therapeutic target for CI/R injury.
Characterization of Talaromyces islandicus–mediated silver nanoparticles and evaluation of their antibacterial and anticancer potential
Authors: Kamradgi Sangeeta , Babanagare Shankaravva , Gunagambhire Vidyasagar 
Published: January 2022

AbstractThe biosynthesized silver nanoparticles (AgNPs) have been reported to possess several therapeutic applications. Silver is one of the important metals known for its bioactive properties not only as macromolecule but also as nanoparticle (NP). The current research focused on the eco‐friendly synthesis of Talaromyces islandicus VSGF1(Lab code) –mediated AgNPs. The aqueous culture filtrate of T. islandicus VSGF1 was used as a reducing agent. The formation of AgNPs was confirmed by observing the color change from colorless to colloidal earthy‐colored and a sharp absorption peak of ultraviolet–visible (UV‐vis) spectroscopy at 400 nm. Fourier‐transform infrared spectroscopy revealed the involvement of various functional groups for the formation and stabilization of AgNPs. The structure, size, and shape of mycosynthesized AgNPs were identified by X‐ray diffraction (XRD), scanning electron microscopy, and atomic force microscopy (AFM) analysis. The XRD analysis exhibited crystalline nature of NPs whereas AFM analysis revealed the spherical shape of AgNP with average size range between 13 and 66 nm. The antibacterial activity of AgNPs (50 μg/ml) investigated against gram‐positive and gram‐negative bacteria revealed maximum zone of inhibition (ZOI) against drug‐resistant Enterococcus faecalis MTCC439 (18.66 ± 0.57 mm) and Pseudomonas aeruginosa MTCC96 (16 ± 0 mm) followed by Staphylococcus aureus MTCC96 (15.33 ± 0.57 mm), Bacillus subtilis MTCC441 (14.66 ± 0.57 mm), and Escherichia coli MTCC45 (14.66 ± 0.57 mm). Further, the AgNPs evaluated for antitumor activity against human hepatocellular carcinoma (HepG2) cell line exhibited promising result with half‐maximal inhibitory concentration (MIC) value at 38.17 μg/ml concentration through MTT (methylthiazolyl tetrazolium assay) assay. Apparently, this is the first report from T. islandicus to the best of our knowledge.
Novel putative pathogenic viruses identified in pangolins by mining metagenomic data
Authors: Ning Songyi , Dai Ziyuan , Zhao Chunyan , Feng Zhanghao , Jin Kexin , Yang Shixing , Shen Quan , Wang Xiaochun , Sun Runfeng , Zhang Wen 
Published: January 2022

AbstractThe pangolin is the only scaly mammal in the world and also an important reservoir of pathogenic viruses. Habitat loss and poaching have been shrinking the survival range of pangolins. More information on pangolin virus populations is needed to better understand and assess potential disease risks. In this study, viral metagenomic data were used to reinvestigate the virome in pangolin lung tissue. Complete genome sequences of two novel anelloviruses were acquired and clustered with the referenced feline strains belonging to genus Tettorquevirus and genus Etatorquevirus, respectively. Two genomes belonging to the genus Gemykibivirus, and species Bat‐associated cyclovirus 9 were detected, respectively. One genome with a large contig belonging to the genus Senecavirus were also characterized, according to phylogenetic analysis, which can be presumed to be a novel species. In addition, a full genome of endogenous retroviruse (ERV) was assembled from the lungs of pangolin, and this virus may have the possibility of cross‐species transmission during the evolution. This virological investigation has increased our understanding of the virome carried by pangolins and provided a reference baseline for possible zoonotic infectious diseases in the future.
Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration
Authors: Chang Peng , Zhang Wenchang , Wu Mi , Zou Rufei , Song Xiaoqiang , Sun Qian , Gao Junqing , Zhao Yan , Liu Yunhui 
Published: January 2022

AbstractThe construction of intact functional skin is a challenging field in tissue engineering. Traditional skin tissue engineering, using “seed cells” as a bioactive source for scaffolding materials maybe not efficient enough. Here a new strategy is shown for constructing functional tissue‐engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity. Chitosan/gelatin non‐woven fabric is used as the scaffold. MFUS is derived from autologous skin with full‐thickness skin microstructure and complete functional skin unit harvesting. A mathematical model is used to calculate the MFUS Minimal Harvest Diameter and Angle (MHDA). Chitosan/gelatin non‐woven fabric (CS+GEL) is porous and absorbable, with an elastic modulus meeting the requirement of skin engineering. It supports layered and 3D growth of MFUS. The degradation rate of chitosan, including filament diameter and density is evaluated in vivo. MFUS‐engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation. This study proposes a new strategy for the clinical treatment of large full‐thickness skin defects by constructing intact functional at minimal cost.
Sunlight Induced Polymerization Photoinitiated by Novel Push–Pull Dyes: Indane‐1,3‐Dione, 1H‐Cyclopenta[b]Naphthalene‐1,3(2H)‐Dione and 4‐Dimethoxyphenyl‐1‐Allylidene Derivatives
Authors: Sun Ke , Pigot Corentin , Zhang Yijun , Borjigin Timur , Morlet‐Savary Fabrice , Graff Bernadette , Nechab Malek , Xiao Pu , Dumur Frédéric , Lalevée Jacques 
Published: January 2022

AbstractThe free radical polymerization of acrylates photo‐initiated by push–pull dye‐based photoinitiating systems (PISs) is widely investigated in previous works. As a supplementary investigation on push–pull dyes, here in this article, 25 push–pull structures comprising electron acceptors derived from indane‐1,3‐dione and 1H‐cyclopenta[b]naphthalene‐1,3(2H)‐dione (series 1) and 4‐dimethoxyphenyl‐1‐allylidene moieties (series 2) and various electron donors are synthesized and examined as innovative structures for photoinitiation. Among the two series of dyes examined in this work and by monitoring the polymerization processes by RT‐FTIR measurements, four dyes are determined as exhibiting excellent photoinitiation performances and these dyes are selected to perform further studies concerning the chemical mechanisms occurring inside the three‐component PISs, for example, steady state photolysis, fluorescence quenching measurements, and cyclic voltammetry. Markedly, their reactivity is also proved by photoinitiation performance upon sunlight. These results prompt us to develop high performance push–pull dyes as photosensitizers and sunlight can be used as a mild and ecofriendly light source, which can advantageously replace LEDs for the free radical photopolymerization in the future. Finally, the formation of 3D patterns with an excellent gradient of resolution is successfully achieved by the direct laser write (DLW) with/without silica fillers.
Implementation of cyclic olefin copolymer‐based microwave circuit and the performance comparison
Authors: Li Hongping , Chen Haidong , Chen Huibing , Yan Mengzhu , Xue Quan , Che Wenquan 
Published: January 2022

AbstractThe fabrication process of an advanced transparent cyclic olefin copolymer (COC)‐based laminate is introduced, along with the laser cutting technology for circuit pattern. Then, a three‐way Gysel divider with an equal power‐dividing ratio is reviewed, designed and measured, based on the proposed COC‐based laminate. The measured results are compared to those from a similar three‐way Gysel divider based on traditional RT/duroid 5880 laminate, from which we can see that COC‐based laminate has the advantage of lower loss, with other advantages such as low cost, easy realization, high‐precision, and even the transparency. This laminate can be an excellent candidate for a substrate at microwave or millimeter‐wave circuits.
Effects of colchicine on lipolysis and adipose tissue inflammation in adults with obesity and metabolic syndrome
Authors: Levine Jordan A. , Sarrafan‐Chaharsoughi Zahra , Patel Tushar P. , Brady Sheila M. , Chivukula K. Karthik , Miller Emily , Han Jung Min , Periwal Vipul , Wolska Anna , Remaley Alan T. , Dagur Pradeep K. , Biancotto Angelique , Babyak Ashley , Fantoni Giovanna , Yanovski Jack A. , Demidowich Andrew P. 
Published: January 2022

AbstractObjectiveThe aim of this study was to examine whether colchicine’s anti‐inflammatory effects would improve measures of lipolysis and distribution of leukocyte populations in subcutaneous adipose tissue (SAT).MethodsA secondary analysis was conducted for a double‐blind, randomized, placebo‐controlled pilot study in which 40 adults with obesity and metabolic syndrome (MetS) were randomized to colchicine 0.6 mg or placebo twice daily for 3 months. Non‐insulin‐suppressible (l0), insulin‐suppressible (l2), and maximal (l0+l2) lipolysis rates were calculated by minimal model analysis. Body composition was determined by dual‐energy x‐ray absorptiometry. SAT leukocyte populations were characterized by flow cytometry analysis from biopsied samples obtained before and after the intervention.ResultsColchicine treatment significantly decreased l2 and l0+l2 versus placebo (p < 0.05). These changes were associated with a significant reduction in markers of systemic inflammation, including high‐sensitivity C‐reactive protein, resistin, and circulating monocytes and neutrophils (p < 0.01). Colchicine did not significantly alter SAT leukocyte population distributions (p > 0.05).ConclusionsIn adults with obesity and MetS, colchicine appears to improve insulin regulation of lipolysis and reduce markers of systemic inflammation independent of an effect on local leukocyte distributions in SAT. Further studies are needed to better understand the mechanisms by which colchicine affects adipose tissue metabolic pathways in adults with obesity and MetS.
Progressive mean as a special case of exponentially weighted moving average: Discussion
Authors: Abbas Nasir , Riaz Muhammad 
Published: January 2022

AbstractAbbas1 showed mathematically that progressive mean statistic can be viewed as exponentially weighted moving average statistic with varying sensitivity parameter. A recently published study claims to invalidate the result using the justification that the variance of progressive mean (PM) statistic is different from the variance of exponentially weighted moving average statistic. This study reiterates and extends the initial result established by Abbas1 and proves mathematically that not only the statistics but also the sampling variance of PM becomes a special case of exponentially weighted moving average with varying sensitivity parameter. Moreover, the study discusses that the performance of PM chart declines for steady state process and how it can be recovered by combining it with Shewhart chart.