bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Experimental Approach to Evaluate Film Thickness in Starved Large-Size Spinning Contacts
Authors: Porras-Vazquez Alberto , Philippon David , Fillot Nicolas , Vergne Philippe , Devaux Nicolas , Lafarge Lionel , Morales-Espejel Guillermo E. 
Published: June 2022

Abstract
In the present work, we evaluate the effects of lubricant starvation on the film thickness of spinning large-size point contacts from an experimental standpoint. This kind of contact is found in roller bearings in which the lubrication of the roller-end/flange contacts may be critical with respect to the system performance. First, the conception and validation of a dedicated experimental setup inducing both test conditions, either independently or combined, is exposed. Then, the work presents novel experimental measurements that corroborate the numerical trends determined in earlier work from the authors and describe the behavior of such contacts from the perspective of its kinematic field. Finally, both maximum and minimum film thicknesses obtained experimentally and numerically are gathered in a chart and compared well with the results given by a hybrid analytical model, combining independently starvation and spinning influences.
Supplemental Material: New constraints on the source of loess from U/Th-Pb geochronology of detrital multi-minerals
Authors: Zhou Guangyan , Wu Yuanbao , al. et 
Published: June 2022

<p>Geological background of the Chinese Loess Plateau source regions, samples and analytical methods, supplemental Figures S1–S4, and data tables S1–S4. </p>
What do healthcare professionals want from a resource to support person-centred conversations on physical activity? A mixed-methods, user-centric approach to developing educational resources
Authors: Reid Hamish , Caterson Jessica , Smith Ralph , Baldock James , Jones Natasha , Copeland Robert 
Published: June 2022

ObjectivesHealthcare is a fundamental action area in population efforts to address the global disease burden from physical inactivity. However, healthcare professionals lack the knowledge, skills and confidence to have regular conversations about physical activity. This study aimed to: (1) understand the requirements of healthcare professionals and patients from a resource to support routine physical activity conversations in clinical consultations and (2) develop such a resource.MethodsThis study used codesign principles across two phases, actively involving relevant stakeholders in an iterative development process. The preparatory phase included a scoping literature review and workshops with multidisciplinary healthcare professionals and patients. The Delphi phase included the development of a draft resource, a three-stage modified online Delphi study and an external review.ResultsThe scoping review highlighted the importance of addressing time restrictions, a behaviour change skill deficit, the need for resources to fit into existing systems and meeting patient expectations. Consultation included 69 participants across two clinical workshops. They recommended using the internet, valued guidance on all aspects of physical activity conversations and were concerned about how to use a person-centred approach. The Delphi phase, including 15 expert participants, met agreement criteria in two stages to develop the resource.ConclusionThis mixed-methods study delivered an online resource that was codesigned with and based on the requirements of healthcare professionals and patients. The resource presents condition-specific ‘1-minute’, ‘5-minute’ and ‘more minute’ person-centred and evidence-based conversation templates on physical activity in an accessible and usable format to meet the needs of real-life clinical practice.
Incompatible bounded category forcing axioms
Authors: Asperó David , Viale Matteo 
Published: June 2022

We introduce bounded category forcing axioms for well-behaved classes [Formula: see text]. These are strong forms of bounded forcing axioms which completely decide the theory of some initial segment of the universe [Formula: see text] modulo forcing in [Formula: see text], for some cardinal [Formula: see text] naturally associated to [Formula: see text]. These axioms naturally extend projective absoluteness for arbitrary set-forcing — in this situation [Formula: see text] — to classes [Formula: see text] with [Formula: see text]. Unlike projective absoluteness, these higher bounded category forcing axioms do not follow from large cardinal axioms but can be forced under mild large cardinal assumptions on [Formula: see text]. We also show the existence of many classes [Formula: see text] with [Formula: see text] giving rise to pairwise incompatible theories for [Formula: see text].
Bilateral Adrenal Hemorrhage and Adrenal Insufficiency in the Context of Polycythemia Vera: A Case Report and Review of the Literature
Authors: Soltanmohammadi Sara , Vakhshoori Mehrbod , Sajadi Ghazaleh , Heidarpour Maryam 
Published: June 2022

Background. Polycythemia vera (PV) is a myeloproliferative disorder presented with different manifestations. However, bilateral adrenal hemorrhage (BAH) and adrenal insufficiency (AI) are rare manifestations. Herein, we described a patient who suffered from BAH and AI in the context of PV. Case Presentation. A 60-year-old man with an underlying history of PV was admitted with severe abdominal pain, nausea, and loss of consciousness. Primitive computed tomography (CT) scan findings revealed bilateral adrenal masses (right: 40

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23 mm, left: 60

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35 mm) with the second scan showing quite similar results (right adrenal: 40

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29 mm, left adrenal: 48

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26 mm) suggesting BAH. The further adrenal assessment proved concurrent AI. Both adrenal masses resolved completely after 15 months. However, the patient still suffered from AI. Conclusion. BAH and AI in patients with PV should be considered rare complications requiring high clinical suspicion for early diagnosis and treatment to avoid life-threatening outcomes.
Abstract A09: Characteristics of uveal melanoma patients with central nervous system metastases
Authors: Patel Sapna P. , Hwu Patrick , Davies Michael , Wong Michael , Tawbi Hussein , Amaria Rodabe , Diab Adi , Gombos Dan , Glitza Isabella C. 
Published: June 2022

Abstract
In contrast to cutaneous melanoma, central nervous system (CNS) metastasis from uveal melanoma are uncommon, occurring in less than 5% of uveal patients. There is no published literature describing the features or survival of this unique population. Here we describe the clinical characteristics and outcomes of uveal melanoma CNS metastasis patients. We performed an MD Anderson Cancer Center institutional database review from 1999–2017 for consecutive uveal melanoma patients with CNS metastasis. Excluding dural-based metastases, 19 patients were identified. Ethnic makeup was 84% White, 11% Hispanic, 5% other, and median age at diagnosis was 52.4 years. The gender distribution was 12 (63%) female and 7 (37%) male. Primary tumor location in the uveal tract was 26% choroid, 11% iridociliary, 5% chiliochoroidal, and 58% not otherwise specified. Seven of 19 (37%) patients were treated with enucleation; 63% received radiation therapy for primary uveal melanoma. Median interval from diagnosis of uveal melanoma to diagnosis of CNS metastasis was 5 years. Only 7 patients had molecular testing for mutations. Of these, all had G-alpha mutations: 4 (57%) with GNAQ, and 3 (43%) with GNA11 hotspot mutations in Q209. At the time of data cutoff, 14 of 19 (74%) patients were deceased. Additional clinical information regarding treatment for CNS metastasis, histopathologic evaluation, and overall survival will be presented at the meeting.
Citation Format: Sapna P. Patel, Patrick Hwu, Michael Davies, Michael Wong, Hussein Tawbi, Rodabe Amaria, Adi Diab, Dan Gombos, Isabella C. Glitza. Characteristics of uveal melanoma patients with central nervous system metastases [abstract]. In: Proceedings of the AACR Special Conference on Melanoma: From Biology to Target; 2019 Jan 15-18; Houston, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(19 Suppl):Abstract nr A09.
Abstract B05: Sox10 differentially regulates receptor tyrosine kinase expression in melanomas
Authors: Capparelli Claudia , Purwin Timothy , Aplin Andrew 
Published: June 2022

Abstract
Targeting the ErbB3-ErbB2 pathway increases the efficacy of MEK inhibitors in melanoma. Given the inter- and intratumor heterogeneity of melanoma, identifying biomarkers for cells within tumors that will respond effectively to MEK inhibitor-anti-ErbB3 cotargeting is crucial. To this end, we sought to identify transcriptional regulators of ErbB3. Several transcription factors (TFs) are predicted to bind to the promoter region of ErbB3. Using correlation analysis, SOX10 was positively correlated with ErbB3 expression in the RNA-seq data from TCGA cutaneous melanoma dataset. By contrast, an inverse correlation existed between SOX10 and other receptor tyrosine kinases, EGFR and PDGFR, which have been associated with a slow-growing phenotype and resistance to BRAF and MEK inhibitors. siRNA and CRISPR knockdown/out experiments confirmed that SOX10 positively regulates ErbB3 but negatively regulates PDGFR, suggesting plasticity between SOX10-positive and SOX10-negative populations with regard to RTK expression. Overall, this study suggests that SOX10 is a potential biomarker of responsiveness to MEK inhibitor plus ErbB3 targeting antibody in melanoma.
Citation Format: Claudia Capparelli, Timothy Purwin, Andrew Aplin. Sox10 differentially regulates receptor tyrosine kinase expression in melanomas [abstract]. In: Proceedings of the AACR Special Conference on Melanoma: From Biology to Target; 2019 Jan 15-18; Houston, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(19 Suppl):Abstract nr B05.
Abstract B25: Demographic characteristics and peripheral blood clinical laboratory variables predict irAE occurrence in patients with advanced melanoma receiving anti-PD-1 monotherapy
Authors: Bai Xue , Kim Michelle S. , Kasumova Gyulnara , Cohen Justine , Lawrence Donald , Freedman Christine , Fadden Riley , Rubin Krista , Sharova Tatyana , Flaherty Keith , Sullivan Ryan , Boland Genevieve 
Published: June 2022

Abstract
Background: Although immune-related adverse effects (irAEs) are commonly seen in anti-PD-1 monotherapy-treated patients, their predictive biomarkers are still lacking.
Methods: In this retrospective analysis, clinical data were collected from 141 advanced melanoma patients treated with anti-PD-1 monotherapy at Massachusetts General Hospital from Sept. 2009 to Dec. 2017. Demographic characteristics, baseline, and early-on-treatment (median 3 weeks after anti-PD-1 monotherapy initiation) routine laboratory variables were collected and correlated with occurrence of irAEs in both univariate and multivariate analyses.
Results: 80/141 (56.7%) patients developed irAEs after anti-PD-1 monotherapy initiation. Significant independent predictive variables (P &lt; 0.05) in favor of the occurrence of irAEs included the following: with no distant metastasis (Stage M0) before treatment initiation, high baseline neutrophils, and high early-on-treatment neutrophil-to-lymphocyte ratio (NLR). High baseline monocytes, high baseline basophils, and high early-on-treatment WBCs were of borderline significance (P &lt; 0.1) in multivariate analyses. An irAE risk scoring model (total scale: 0-6) comprising these 6 factors (all as dichotomous variables) was established (HR 1.781, 95% CI 1.450 – 2.187, P &lt; 0.001). Risks of developing at least one irAE within 12 weeks after anti-PD-1 monotherapy initiation were 0%, 21%, 21%, 39%, 30%, and 63%; within 48 weeks were 0%, 41%, 57%, 68%, 77%, and 100%, for patients with scores of 0 to 5 (no patient scored 6 within this cohort), respectively.
Conclusions: Scoring system based on simple, easily accessible, and routinely tested biomarkers could be used to help predict the risk of irAEs occurrence in anti-PD-1 monotherapy-treated advanced melanoma patients.
Citation Format: Xue Bai, Michelle S. Kim, Gyulnara Kasumova, Justine Cohen, Donald Lawrence, Christine Freedman, Riley Fadden, Krista Rubin, Tatyana Sharova, Keith Flaherty, Ryan Sullivan, Genevieve Boland. Demographic characteristics and peripheral blood clinical laboratory variables predict irAE occurrence in patients with advanced melanoma receiving anti-PD-1 monotherapy [abstract]. In: Proceedings of the AACR Special Conference on Melanoma: From Biology to Target; 2019 Jan 15-18; Houston, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(19 Suppl):Abstract nr B25.
Abstract IA05: Distinct immune and molecular features of melanoma brain metastases
Authors: Davies Michael A. 
Published: June 2022

Abstract
Brain metastases are a common and devastating complication of metastatic melanoma. Clinical trials have shown that targeted and immune therapies frequently achieve less favorable results in melanoma brain metastases than in other metastatic sites, and the central nervous system (CNS) is a common initial site of systemic treatment failure in this disease. Several previous focused studies demonstrated significant differences between melanoma brain metastases (MBMs) and extracranial metastases (ECMs) that may contribute to therapeutic resistance. However, very little data are currently available about the global features of MBMs, particularly in comparison to patient-matched ECMs. Thus, we performed RNA sequencing (RNAseq) on a large cohort of resected MBMs, and resected ECMs, from metastatic melanoma patients treated at our institution. Parallel studies were performed on preclinical models of MBMs to further and functionally characterize these tumors. These studies have identified unique immune and metabolic features of MBMs. These differences provide new insights into possible mechanisms of therapeutic resistance among MBMs and suggest rational approaches to improve the efficacy of treatments for them.
Citation Format: Michael A. Davies. Distinct immune and molecular features of melanoma brain metastases [abstract]. In: Proceedings of the AACR Special Conference on Melanoma: From Biology to Target; 2019 Jan 15-18; Houston, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(19 Suppl):Abstract nr IA05.
Abstract IA08: Elevated endogenous SDHA drives pathologic metabolism in highly metastatic uveal melanoma
Authors: Chattopadhyay Chandrani , Oba Junna , Roszik Jason , Woodman Scott E. , Grimm Elizabeth A. 
Published: June 2022

Abstract
Purpose: Metastatic uveal melanoma (UM) has a very poor prognosis and no effective therapy. Despite remarkable advances in treatment of cutaneous melanoma, UM remains recalcitrant to chemotherapy, small-molecule kinase inhibitors, and immune-based therapy.
Experimental Design: We assessed two sets of oxidative phosphorylation (OxPhos) genes within 9,858 tumors across 31 cancer types. An OxPhos inhibitor was used to characterize differential metabolic programming of highly metastatic monosomy 3 (M3) UM. Seahorse analysis and global metabolomics profiling were done to identify metabolic vulnerabilities. Analyses of UM TCGA data set were performed to determine expressions of key OxPhos effectors in M3 and non M3 UM. We used targeted knockdown of succinate dehydrogenase A (SDHA) to determine the role of SDHA in M3 UM in conferring resistance to OxPhos inhibition.
Results: We identified UM as having among the highest median OxPhos levels and showed that M3 UM exhibits a distinct metabolic profile. M3 UM shows markedly low succinate levels and has highly increased levels of SDHA, the enzyme that couples the TCA cycle with OxPhos by oxidizing (lowering) succinate. We show that SDHA-high M3 UM has elevated expression of key OxPhos molecules, exhibits abundant mitochondrial reserve respiratory capacity, and is resistant to OxPhos antagonism, which can be reversed by SDHA knockdown.
Conclusions: Our study has identified a critical metabolic program within poor prognostic M3 UM. In addition to the heightened mitochondrial functional capacity due to elevated SDHA, M3 UM SDHA-high mediates resistance to therapy that is reversible with targeted treatment.
Citation Format: Chandrani Chattopadhyay, Junna Oba, Jason Roszik, Scott E. Woodman, Elizabeth A. Grimm. Elevated endogenous SDHA drives pathologic metabolism in highly metastatic uveal melanoma [abstract]. In: Proceedings of the AACR Special Conference on Melanoma: From Biology to Target; 2019 Jan 15-18; Houston, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(19 Suppl):Abstract nr IA08.
Design and modeling of solar water pumping system in Diyala region
Authors: Ali Mohammed Hasan , Mejeed Raghad Ali 
Published: June 2022

In recent years, <span>solar panels have become increasingly popular for converting solar energy is converted into electrical energy. The solar panel can be utilized as part of a larger solar system that is connected to the power grid or as a stand-alone system. Every day, the world receives 84 Terawatts of energy, yet we only use about 12 Terawatts. For optimal energy conversion, the tracking mechanism will keep the solar panel perpendicular to the sun at all times. In this setup, photo resistors will be employed as sensors. A light detection system, a microprocessor, a gear motor system, and a solar panel will make up the system. When compared to solar panels without tracking equipment, our system will produce up to 40% more electricity. Improvements to the board's efficiency include the addition of a dust sensor. The dust on the board is also detected by the sensor, which activates a pump inside the tank. It uses the Arduino to pump water onto the board to clean it of dust and maintain its efficiency. There is also a water sensor. When the tank's water level falls below a certain level, the attached pump activates.</span>
Postnatal Deletion of Bmal1 in Cardiomyocyte Promotes Pressure Overload Induced Cardiac Remodeling in Mice
Authors: Liang Qing , Xu Hu , Liu Min , Qian Lei , Yan Jin , Yang Guangrui , Chen Lihong 
Published: June 2022

Background
Mice with cardiomyocyte‐specific deletion of Bmal1, a core clock gene, had spontaneous abnormal cardiac metabolism, dilated cardiomyopathy, and shortened lifespan. However, the role of cardiomyocyte Bmal1 in pressure overload induced cardiac remodeling is unknown. Here we aimed to understand the contribution of cardiomyocyte Bmal1 to cardiac remodeling in response to pressure overload induced by transverse aortic constriction or chronic angiotensin Ⅱ (AngⅡ) infusion.

Methods and Results
By generating a tamoxifen‐inducible cardiomyocyte‐specific Bmal1 knockout mouse line (cKO) and challenging the mice with transverse aortic constriction or AngⅡ, we found that compared to littermate controls, the cKO mice displayed remarkably increased cardiac hypertrophy and augmented fibrosis both after transverse aortic constriction and AngⅡ induction, as assessed by echocardiographic, gravimetric, histologic, and molecular analyses. Mechanistically, RNA‐sequencing analysis of the heart after transverse aortic constriction exposure revealed that the PI3K/AKT signaling pathway was significantly activated in the cKOs. Consistent with the in vivo findings, in vitro study showed that knockdown of Bmal1 in cardiomyocytes significantly promoted phenylephrine‐induced cardiomyocyte hypertrophy and triggered fibroblast‐to‐myofibroblast differentiation, while inhibition of AKT remarkedly reversed the pro‐hypertrophy and pro‐fibrosis effects of Bmal1 knocking down.

Conclusions
These results suggest that postnatal deletion of Bmal1 in cardiomyocytes may promote pressure overload‐induced cardiac remodeling. Moreover, we identified PI3K/AKT signaling pathway as the potential mechanistic ties between Bmal1 and cardiac remodeling.
Rheumatic Heart Disease Is a Neglected Disease Relative to Its Burden Worldwide: Findings From Global Burden of Disease 2019
Authors: Ghamari Seyyed‐Hadi , Abbasi‐Kangevari Mohsen , Saeedi Moghaddam Sahar , Aminorroaya Arya , Rezaei Negar , Shobeiri Parnian , Esfahani Zahra , Malekpour Mohammad‐Reza , Rezaei Nazila , Ghanbari Ali , Keykhaei Mohammad , Naderian Mohammadreza , Larijani Bagher , Majnoon Mohamad Taghi , Farzadfar Farshad , Mokdad Ali H. 
Published: June 2022

Background
Rheumatic heart disease (RHD) takes a heavy toll in low‐ and middle‐income countries. We aimed to present worldwide estimates for the burden of the RHD during 1990 to 2019 using the GBD (Global Burden of Disease) study.

Methods and Results
Sociodemographic index (SDI) and age‐period‐cohort analysis were used to assess inequity. The age‐standardized death, disability‐adjusted life years, incidence, and prevalence rates of RHD were 3.9 (95% uncertainty interval, 3.3–4.3), 132.9 (95% uncertainty interval, 115.0–150.3), 37.4 (28.6–46.7), and 513.7 (405.0–636.3) per 100 000 in 2019, respectively. The age‐standardized incidence and prevalence rates increased by 14.4% and 13.8%, respectively. However, disability‐adjusted life years and death rates decreased by 53.1% and 56.9%, respectively. South Asia superregion had the highest age‐standardized disability‐adjusted life years and deaths. Sub‐Saharan Africa had the highest age‐standardized incidence and prevalence rates. There was a steep decline in RHD burden among higher‐SDI countries. However, only age‐standardized deaths and disability‐adjusted life years rates decreased in lower‐SDI countries. The age‐standardized years of life lost and years lived with disability rates for RHD significantly declined as countries' SDI increased. The coefficients of birth cohort effect on the incidence of RHD showed an increasing trend from 1960 to 1964 to 2015 to 2019; however, the birth cohort effect on deaths attributable to RHD showed unfailingly decreasing trends from 1910 to 1914 to 2015 to 2019.

Conclusions
There was a divergence in the burden of RHD among countries based on SDI levels, which calls for including RHD in global assistance and funding. Indeed, many countries are still dealing with an unfinished infectious disease agenda, and there is an urgency to act now to prevent an increase in future RHD burden.
Dynamic and Thermodynamic Factors Involved in Future Changes in Extreme Summertime Precipitation in Japan Projected by Convection-Permitting Regional Climate Model Simulations
Authors: Murata Akihiko , Nosaka Masaya , Sasaki Hidetaka , Kawase Hiroaki 
Published: June 2022

Abstract
Dynamic and thermodynamic factors involved in future changes in local-scale short-term extreme summertime precipitation on the mesoscale and hourly time scale in Japan were examined using convection-permitting regional climate model simulations under the representative concentration pathway 8.5 scenario. The change in the dynamic component primarily contributes to the total change in vertically integrated moisture flux convergence over the analysis domain that is located off Okinawa Island, whereas the thermodynamic component is dominant over the analysis domain that is located off Kyushu Island. Differences in the amount of the dynamic and thermodynamic components are noticeable in these two domains. These results are explained by the difference in the vertical profiles of the convergence term, and hence the convergence itself between the two specific domains. A mesoscale low pressure system on the seasonal rain front—termed the baiu front—is a key factor underlying the difference in the magnitudes and vertical profiles of convergence between the two specific domains. In the vicinity of the domain off Okinawa Island, a mesoscale low pressure system on the baiu front enhances low-level convergence in the future climate when compared with the present climate. This atmospheric state is attributable to the location of the baiu front itself, which is located relatively southward in the future climate and is affected by the domain off Okinawa Island. In the domain where the dynamic component is dominant such as the domain off Okinawa Island, the total moisture flux convergence follows a super–Clausius–Clapeyron scaling.