bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring patients with uncomplicated common variable immunodeficiency: a systematic review
Authors: Lee Erika Yue , Betschel Stephen , Grunebaum Eyal 
Published: March 2022

Abstract
Background
Non-infectious complications have become a major cause of morbidity and mortality in patients with Common Variable Immunodeficiency (CVID). The monitoring of patients with CVID prior to the development of non-infectious complications is not well defined.

Objective
Our objectives were to systematically review the current literature on the monitoring of CVID patients without non-infectious complications and to develop recommendations for such monitoring.

Methods
MEDLINE and EMBASE were searched from January 1st, 2000 to March 25th, 2021. Studies on any aspects of CVID monitoring were included. Studies that included only children, on monitoring CVID patients with existing non-infectious complications, or in the format of case reports were excluded.

Results
Nine studies on CVID monitoring, including 3 cohort studies, 3 experts’ opinions, 2 consensus statements and a single guideline report were identified. These studies revealed that clinical assessment and bloodwork were preformed every 6 to 12 months in asymptomatic patients. Some centers performed computerized tomography scan of the chest every 2–5 years to identify chronic lung disease, although the majority did chest imaging in accordance with clinical indications. Pulmonary function tests were done annually at most centers. Most studies did not address the role of abdominal imaging to screen for liver diseases or endoscopy to screen for gastric cancer in asymptomatic patients with uncomplicated CVID.

Conclusions
There is paucity of evidence-based information to guide the routine monitoring of CVID patients without non-infectious complications. Prospective studies are needed to determine the best monitoring practices in this group of patients.
Change in waist circumference and lifestyle habit factors as a predictor of metabolic risk among middle-aged and elderly Japanese people: population-based retrospective 10-year follow-up study from 2008 to 2017
Authors: Ono Haruko , Akahoshi Kotomi , Kai Michiaki 
Published: March 2022

Abstract
Background
Waist circumference (WC) increases more than body mass index (BMI) over time. This study investigated the change in WC among middle-aged and elderly Japanese people for 10 years, and its relationship with lifestyle and lipid metabolism factor.

Methods
Health checkup data and lifestyle habits of a retrospective cohort of 745 people aged 40–65 years who underwent health checkups at least three times between 2008 and 2017 were analyzed. Information of Lifestyle habits about smoking history, regular exercise, alcohol intake skipping breakfast was collected using a self-administered questionnaire. Participants who were taking medications for diabetes, hyperlipidemia, or hypertension were excluded from analyses. Longitudinal associations between the change in WC and lifestyle habit factors with adjustments for sex, age, and WC at the start of health checkups were assessed using generalized linear models.

Results
Regardless of lifestyle, body weight (BW) decreased 0.8 kg (p < 0.001) for women, 0.9 kg (p = 0.003) for men, WC increased 0.8 cm (p = 0.007) for women, 0.2 cm (p = 0.657) for men. In addition, serum triglycerides and high- and low-density lipoprotein levels estimated 10 years later revealed that increased WC ratios also exacerbated the respective blood sample data.

Conclusion
Both men and women showed an increase in WC regardless of BW changes, and the increase in WC worsened lipid metabolism. For the middle-aged and elderly, whose WC increases over time, it will be more important to take notice of their WC than BW or BMI for effective health checkups.
The status of infection prevention and control structures in Eastern China based on the IPCAF tool of the World Health Organization
Authors: Ni Kaiwen , Jin Dingping , Wu Zhe , Sun Liyuan , Lu Qun 
Published: March 2022

Abstract
Background
The burden of healthcare-associated infections (HAIs) and the spread of antimicrobial resistance can be potentially preventable through comprehensive infection prevention and control (IPC) programs. However, information on the current state of IPC implementation is rare in China.

Methods
A cross-sectional study was conducted in Zhejiang province, China, from April to June 2021. The Zhejiang nosocomial infection control and quality improvement center (NICQI) cooperated with 11 municipal NICQI centers to introduce the purpose of this study and invite all licensed secondary and tertiary hospitals in Zhejiang province through WeChat group. The questionnaire had three sections, including information about participating hospitals, demographic information about IPs, and the Chinese version of the Infection Prevention and Control Assessment Framework that covered eight core components (CC).

Results
Of the 382 hospitals invited, 222 (58.1% response rate) accepted and completed the online questionnaire. The overall median score of the participating hospitals was 682 (630–723), which corresponded to an advanced level of IPC. There was a significant difference in scores between hospitals types (P < 0.001). Profound differences were revealed regarding the scores of the individual components, with CC2 (IPC guidelines) and CC6 (Monitoring/audit of IPC practices and feedback) having the highest (100) and lowest (65) median scores, respectively. Only 23 (10.4%) hospitals reported assessing facility safety culture.

Conclusions
IPC structures are at a relatively high level in acute care hospitals in Eastern China. The identified potential areas for improvement were similar to those identified in developed countries, particularly regarding multimodal strategies for implementation and safety culture construction. Meanwhile, the Chinese government should pay more attention to IPC resources and practices among secondary care hospitals.
Association between fat mass by bioelectrical impedance analysis and bone mass by quantitative ultrasound in relation to grip strength and serum 25-hydroxyvitamin D in postmenopausal Japanese women: the Unzen study
Authors: Mizukami Satoshi , Arima Kazuhiko , Abe Yasuyo , Tomita Yoshihito , Nakashima Hiroki , Honda Yuzo , Uchiyama Michiko , Ookawachi Tetsuji , Goto Hisashi , Hasegawa Maiko , Sou Youko , Kanagae Mitsuo , Osaki Makoto , Aoyagi Kiyoshi 
Published: March 2022

Abstract
Background
Whether fat mass or lean mass affects bone mass in postmenopausal women is controversial. This study aimed to explore the association between body composition measured by bioelectrical impedance analysis (BIA) and bone mass measured by quantitative ultrasound (QUS) in postmenopausal women in Japan.

Methods
We conducted a cross-sectional study, The Unzen Study, on 382 community-dwelling postmenopausal Japanese women (mean (standard deviation) age: 68.2 (7.2) years) who participated in periodic health examinations. The stiffness index (SI) was measured using QUS, and body composition (e.g., fat mass and muscle mass) was measured using BIA. Grip strength was measured. Fasting blood samples were collected, and 25-hydroxyvitamin D (25(OH)D), tartrate-resistant acid phosphatase-5b (TRACP-5b), and parathyroid hormone (PTH) levels were measured. Data on current smoking, alcohol consumption, exercise, and any comorbidities (heart disease, lung disease, stroke, or diabetes mellitus) were collected.

Results
The SI increased with increasing quartiles of fat mass and muscle mass (both p for trend <  0.001), respectively. There were positive correlations between SI and log (25(OH)D) or grip strength. Fat mass significantly correlated with grip strength. Multiple linear regression analysis showed that higher fat mass was independently and significantly associated with higher SI after adjusting for age, height, comorbidity, current smoking, alcohol consumption, exercise, log (25(OH)D), log (TRACP-5b), log (PTH), and grip strength (p = 0.001). In contrast, no association was observed between muscle mass and SI.

Conclusions
Fat mass, but not muscle mass, was a significant determinant of SI in community-dwelling postmenopausal Japanese women.
In situ XRF investigations to unravel the provenance area of Corinthian ware from excavations in Milazzo (Mylai) and Lipari (Lipára)
Authors: Belfiore Cristina M. , Mastelloni Maria A. , Barone Germana , Mazzoleni Paolo 
Published: March 2022

Abstract
In this contribution a non-destructive approach has been used aiming at investigating the chemical composition of 35 ceramic items belonging to the collections of the Regional Aeolian Museum “Luigi Bernabò Brea” in the Lipari Island (Sicily, Italy). Different vessel types have been selected for analysis, including aryballoi, kotylai, olpai, anforiskoi, oinochoai, and alabastra, belonging to the “Proto-Corinthian and Corinthian” ware classes. The items, dating back to the period comprised between the early eighth and the first half of the sixth century BC, come from two different archaeological sites in the province of Messina (Sicily), specifically the Istmo necropolis of Milazzo, in the northern Sicilian coast, and the acropolis and necropolis of Lipari, in the Aeolian islands. The chemical characterization of ceramics, carried out through portable X-ray fluorescence spectroscopy (pXRF), aimed at gaining information on the production area of examined items whose autoptic analysis pointed to Corinthian imports. The possibility of carrying out experimental investigations on the most ancient materials from the archaic necropolis of Milazzo and on fragments from Lipari, albeit limited to pXRF investigations, allowed to enrich the knowledge on the Corinthian production exported to western areas as well as to discriminate, no longer based solely on autoptic observations and stylistic evaluations, between Corinthian productions and "local" imitations.
Endometrial carcinoma: use of tracer kinetic modeling of dynamic contrast-enhanced MRI for preoperative risk assessment
Authors: Ye Zhijun , Ning Gang , Li Xuesheng , Koh Tong San , Chen Huizhu , Bai Wanjing , Qu Haibo 
Published: March 2022

Abstract
Background
To compare two tracer kinetic models in predicting of preoperative risk types in endometrial carcinoma (EC) using DCE-MRI.

Methods
A prospective study of patients with EC was conducted with institutional ethics approval and written informed consent. DCE-MRI data was analyzed using the extended Tofts (ET) and the distributed parameter (DP) models. DCE parameters blood flow (F), mean transit time, blood volume (Vp), extravascular extracellular volume (Ve), permeability surface area product (PS), extraction fraction, transfer constant (Ktrans), and efflux rate (Kep) between high- and low-risk EC were compared using the Mann–Whitney test. Bland–Altman analysis was utilized to compare parameter consistency and Spearman test to assess parameter correlation. Diagnostic performance of DCE parameters was analyzed by receiver-operating characteristic curve and compared with traditional MRI assessment.

Results
Fifty-one patients comprised the study group. Patients with high-risk EC exhibited significantly lower Ktrans, Kep, F, Vp and PS (P < 0.001). ET-derived Ktrans and DP-derived F attained AUC of 0.92 and 0.91, respectively. Bland–Altman analysis showed that the consistency of Ve or Vp between the two models was low (P < 0.001) while Spearman test showed a strong correlation (r = 0.719, 0.871). Both Ktrans and F showed higher accuracy in predicting EC risk types than traditional MRI assessment.

Conclusions
Kinetic parameters derived from DCE-MRI revealed a more hypovascular microenvironment for high risk EC than to low- risk ones, providing potential imaging biomarkers in preoperative risk assessment that might improve individualized surgical planning and management of EC.
Firm bankruptcies and start-up activity in Switzerland during the COVID-19 crisis
Authors: Eckert Florian , Mikosch Heiner 
Published: March 2022

AbstractThis paper examines the incidence of firm bankruptcies and start-ups in Switzerland based on unique register data. We propose to assess the frequency of bankruptcies over time using the concept of excess mortality. During the COVID-19 crisis in 2020 and the first half of 2021, bankruptcy rates were substantially lower as compared to the pre-crisis period. This holds across most industries and regions. The Great Recession and the Swiss Franc Shock showed reverse patterns. Bankruptcies dropped more in industries and cantons, in which the share of firms who received a COVID-19 loan is comparatively high. In winter 2021, bankruptcies rebounded strongly. Since summer 2020, the number of new firm formations has been significantly higher compared to the time before the crisis. This is also in contrast to the previous crises. The strong start-up activity is driven by industries where the pandemic induced structural adjustments.
Dural Invasion as a Marker of Aggressive Pituitary Adenomas
Authors: Cooper Odelia , Bonert Vivien , Mamelak Adam N. , Bannykh Serguei , Melmed Shlomo 
Published: March 2022

BACKGROUND:
Predictive markers of aggressive pituitary tumors have not been consistently demonstrated. Dural invasion and invasion-associated proteins, including matrix metalloproteinase-9 (MMP9) and cofilin, have been proposed to predict aggressive behavior and recurrence, but findings to date have been inconsistent.

OBJECTIVE:
To assess whether microscopic dural invasion predicts aggressive pituitary adenoma behavior and whether MMP9 and cofilin expression correlates with pathological and clinical invasion markers.

METHODS:
We retrospectively studied 328 consecutive pituitary mass resections by a single neurosurgeon at a single center; 254 were adenomas, and 98 had dural biopsies sent for routine pathological evaluation. Assessments included clinical features, postoperative course, and immunochemical expression of MMP9, cofilin, and phospho-cofilin. Recurrence was evaluated in those with at least 12 months of postoperative follow-up.

RESULTS:
Dural invasion was evident in 48% of biopsy specimens and was associated with male sex, larger tumors, suprasellar extension and sphenoid sinus invasion, cranial nerve palsies, and hypogonadism. Recurrence rates and the expression of MMP9, cofilin, and phospho-cofilin did not differ between those with and without dural invasion. However, differential expression of phospho-cofilin was associated with growth hormone deficiency and compressive pituitary mass effects.

CONCLUSION:
Dural invasion is associated with larger tumors, suprasellar and sphenoid sinus invasion, and pituitary failure but is not predictive of a more aggressive postoperative course. Routine dural biopsy is therefore of limited benefit in predicting postoperative recurrences. Cofilin expression may be an adjunctive biomarker of invasion in recurrent tumors, but MMP9 expression does not predict tumor behavior.
The topography of corticopontine projections is controlled by postmitotic expression of the area-mapping gene Nr2f1
Authors: Tocco Chiara , Øvsthus Martin , Bjaalie Jan G. , Leergaard Trygve B. , Studer Michèle 
Published: March 2022

ABSTRACT
Axonal projections from layer V neurons of distinct neocortical areas are topographically organized into discrete clusters within the pontine nuclei during the establishment of voluntary movements. However, the molecular determinants controlling corticopontine connectivity are insufficiently understood. Here, we show that an intrinsic cortical genetic program driven by Nr2f1 graded expression is directly implicated in the organization of corticopontine topographic mapping. Transgenic mice lacking cortical expression of Nr2f1 and exhibiting areal organization defects were used as model systems to investigate the arrangement of corticopontine projections. By combining three-dimensional digital brain atlas tools, Cre-dependent mouse lines and axonal tracing, we show that Nr2f1 expression in postmitotic neurons spatially and temporally controls somatosensory topographic projections, whereas expression in progenitor cells influences the ratio between corticopontine and corticospinal fibres passing the pontine nuclei. We conclude that cortical gradients of area-patterning genes are directly implicated in the establishment of a topographic somatotopic mapping from the cortex onto pontine nuclei.
Effectiveness of Gatekeeper Training Program (GTP) on awareness, attitude, mental help seeking intention and gatekeeper behavior among Koraga tribe: A study protocol
Authors: Noronha Flavia Sharlet , Jose Tessy Treesa , George Anice , George Linu Sara 
Published: March 2022

Aim: This study aims to build the capacity of the people at grass root level as gatekeepers of mental health. It will assess the effectiveness of the Gatekeeper Training Program (GTP) on gatekeeper behaviour, awareness, attitude, and mental help seeking intention. Design: An evaluative research approach in two phases. Phase 1: Cross-sectional house-to-house exploratory survey. Phase 2: A quasi-experimental design with multiple follow ups at 0, 6 and 12 months. Method: Data will be collected using standardized tools like Mental Health Knowledge Questionnaire (MHKQ), Community Attitude towards Mentally Ill (CAMIS), Mental Help Seeking Intention (MHSIS) and Gatekeeper Behavior Scale (GBS). For Phase 1, a house-to-house survey will be conducted among the selected colonies of Koraga tribe to determine their awareness, attitude, and mental help seeking intention regarding common mental health problems. Phase 2 includes identification of the leaders/representatives of the selected tribal colonies, and involving them in GTP. Pre-test and multiple post-test will be conducted in Phase 2 at 0, 6, 12 months. The study is funded by Indian Council of Medical Research from 16 August 2021 for 3 years duration. Discussion: Treatment gap in psychiatric disorders remains an issue of great concern. Evidence based research promotes task shifting approaches in dealing with mental health problems in the community. Capacity building programs like GTP for the underprivileged section of the society are important especially in low and middle income group of countries. Impact: This need based GTP, will ensure mental health first aid in the society. Early identification of people with mental health problems at their doorsteps has huge impact on the prognosis of the illness, closing the treatment gap and stigma reduction.
Attention and Underreaction-Related Anomalies
Authors: Chen Xin , He Wei , Tao Libin , Yu Jianfeng 
Published: March 2022

Recent studies have proposed a large set of powerful anomaly-based factors in the stock market. This study examines the role of investor inattention in the corresponding anomalies underlying these factors and other underreaction-related anomalies. Using media coverage as a proxy for investor attention, we show that the anomalies underlying many recently proposed prominent factors are much more pronounced among firms with low media coverage in portfolio-formation periods. In addition, we find many other prominent anomalies that previous literature has attributed to underreaction also tend to perform much better among firms with low media coverage. The average Fama-French five-factor alpha spread of these anomalies is about 0.97% per month among firms with low news coverage and only 0.24% per month among firms with high news coverage. Moreover, most of the alpha spread comes from the short leg of the anomalies and from the firms that are more difficult to arbitrage. Overall, our evidence indicates that investor inattention at least partially drives many of the recently proposed factors. This paper was accepted by Haoxiang Zhu, finance. Funding: L. Tao received financial support from the National Natural Science Foundation of China [Grant 72171050], the Ministry of Education Project of Humanities and Social Sciences [Grant No. 17YJCZH161], and the University of International Business and Economics Fund for Distinguished Young Scholars [Grant No. 18JQ07]. J. Yu acknowledges financial support from the National Natural Science Foundation of China [Grant No. 71790591]. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2022.4332 .
Pooling Agents for Customer-Intensive Services
Authors: Wang Zhongbin , Yang Luyi , Cui Shiliang , Ülkü Sezer , Zhou Yong-Pin 
Published: March 2022

To Pool or Not to Pool? Analyzing Customer-Intensive Services with Strategic Agents In customer-intensive services where service quality increases with service time, service providers commonly pool their agents and give performance bonuses that reward agents for achieving greater customer satisfaction and serving more customers. Conventional wisdom suggests that pooling agents reduce customer wait time whereas performance bonuses motivate agents to produce high-quality services, both of which should boost customer satisfaction. However, in “Pooling Agents for Customer-Intensive Services,” Wang, Yang, Cui, Ülkü, and Zhou find that when agents act strategically, they may choose to speed up under pooling in an attempt to serve more customers, thus undermining service quality. If this happens, pooling can backfire and result in both lower customer satisfaction and agent payoff. Consequently, the researchers propose a simple practical solution to restore the efficiency of pooling. They propose pooling a portion of the performance bonuses (incentive pooling) in conjunction with pooling agents (operational pooling).
Awareness and use of prone position for awake patients with suspected COVID-19
Authors: Gander Bradley , Trestrail Nick , Pugh Kieren 
Published: March 2022

Introduction: Evidence is growing that prone positioning may be a simple, safe, and effective technique to improve oxygenation in awake patients with COVID-19 who are unresponsive to initial therapy. However, there is little evidence about its use in the prehospital environment. This study explores clinician awareness and experiences of this in a large ambulance service in south east England. Methods: An online survey was distributed to 3377 operational ambulance clinicians working for the South East Coast Ambulance Service NHS Foundation Trust to assess their awareness of using the prone position for patients with suspected COVID-19 and their experiences of its use in their practice. Results: A total of 278 respondents completed the survey, of whom 229 were aware of the use of the prone position for awake patients with COVID-19 and 18 had attempted to use it in their practice. Ten reported improvements in clinical observations and patient comfort, and six patients showed clinical improvement only. There were no reports of deterioration. The most common reason for not attempting prone positioning was the absence of formal training or guidance. Conclusion: Ambulance clinicians are aware of the use of the prone position for patients with COVID-19 and a small number have used it. The majority of clinicians who were aware of the procedure did not use it because of the lack of guidance or concerns over patient safety. When attempted, prone positioning in prehospital practice may be an example of practice borne of ‘clinical courage’. Further research is needed before the prone position can be routinely used in prehospital practice.