bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune Checkpoint Inhibitor-Induced Hypophysitis and Patterns of Loss of Pituitary Function
Authors: Jessel Shlomit , Weiss Sarah A. , Austin Matthew , Mahajan Amit , Etts Katrina , Zhang Lin , Aizenbud Lilach , Perdigoto Ana Luisa , Hurwitz Michael , Sznol Mario , Herold Kevan C. , Kluger Harriet M. 
Published: March 2022

BackgroundImmune checkpoint inhibitors (ICI) are clinically active across multiple tumor types but the associated immune-related adverse events (irAEs) lead to treatment delays or discontinuation and negatively impact quality-of-life. Hypophysitis is often a permanent irAE that may affect multiple pituitary hormonal axes. Here we comprehensively characterize our institution’s clinical experience with ICI-induced hypophysitis and the associated patterns of pituitary function loss.MethodsPatients with solid tumors, mostly melanoma and renal cell carcinoma (RCC), treated with ICI at Yale Cancer Center were prospectively enrolled from October 2016-May 2021. Demographics and clinical data were obtained from the medical record including type and timing of irAEs. Patients were included in this cohort if hypophysitis was diagnosed by pre-specified biochemical and clinical parameters.ResultsThe overall incidence of hypophysitis was 69/490 (14%) in patients with melanoma (n=58, 84%), RCC (n=10,14%), and merkel cell carcinoma (n=1, 1%) who received ipilimumab plus nivolumab (77%; 53/69), anti-PD-(L)1 (17%; 12/69), or ipilimumab monotherapy (6%; 4/69). Of the 69 patients analyzed, median time to hypophysitis on combination ICI versus anti-PD-1 was 2.8 vs. 4.1 months. The incidence of hypophysitis in patients with melanoma was 25% (46/187) with ipilimumab plus nivolumab and 5% (7/129) with anti-PD-(L)1 compared to 9% (7/77) and 8% (3/37), respectively, in patients with RCC. Patients who developed hypophysitis on combination ICI had a higher rate of headache (p=0.05) and co-occurring irAEs (p=0.01) compared anti-PD-(L1)1 monotherapy. At a median follow-up of 2.2 years, 77% of patients were alive. Objective response rates to ICI in melanoma patients were higher than previously reported for unselected populations. Central hypothyroidism and hypogonadism were the most common pituitary axes affected after the adrenal axis. In select cases, there was evidence of spontaneous rebound in free testosterone levels after an initial decline.ConclusionsWe demonstrate a higher rate of ICI-induced hypophysitis than previously reported, which may be reflective of real-world practice due to increased awareness as experience with ICI has grown. In select cases, there was evidence of rebound in free testosterone and/or gonadotropins but not in adrenal axis hormones.
Spinal Cord Stimulation as an Alternative to Opioid for Axial Neck and Back Pain: A Case Series
Authors: Mullins Graeme Sampson , Burns Joanna Jane , Schneider Andre Perillier , El Helou Antonios 
Published: March 2022

IntroductionSpinal cord stimulation is emerging as a minimally invasive technique for treatment of persistent spinal pain syndrome (PSPS).MethodsWe describe a case series of 25 individuals with PSPS who underwent implantation of a spinal cord stimulator device between 2017 and 2021.ResultsThere was a significant reduction in mean visual analog scale pain scores in the immediate postoperative phase, (8.61 vs. 2.3, p &lt; 0.001). There were twelve patients who consumed pre-operative opioid, and 75% showed reduction of use with a significantly lower average daily dose (66.8 vs. 26.9 meq/D, p &lt; 0.05). There was a significant reduction in the Oswestry Disability Index during postoperative follow-up visits (p &lt; 0.001). There were no major perioperative or long-term complications from the procedure in follow-up.ConclusionThe analysis of this cohort suggests successful long-term treatment of a diverse set of patients with PSPS who underwent spinal cord stimulation (SCS) and had meaningful improvement in quality of life and reduction in opioid consumption.
Exploring Factors and Associate Responses for Anxiety in the Coronavirus Disease 2019 Pandemic: A Web-Based Survey in Japan
Authors: Zhuang Jinman , Cai Guoxi , Lu Yixiao , Xu Xinying , Lin Yulan , Wong Li Ping , Hu Zhijian , Yamamoto Taro , Morita Kouichi , Aoyagi Kiyoshi , He Fei 
Published: March 2022

Background and ObjectivesAnxiety plays an important role in psychology. An exploration of anxiety and its associated reactions may provide insight into measures for addressing mental health problems caused by the coronavirus disease 2019 (COVID-19) pandemic. Data from this study provide potential correlational responses to anxiety.MethodsA cross-sectional study using data collected via an online self-reported questionnaire was conducted in Japan during the COVID-19 pandemic. Using the State-Trait Anxiety Inventory (STAI-6), we assessed anxiety levels and explored the relationship between anxiety STAI-6 score, sources of COVID-19 information, the influences of COVID-19, social anxiety symptoms, discrimination, and evaluation of the government.ResultsA total of 4,127 participants were included in the analysis. The level of anxiety was not equally distributed across the general population with respect to age, gender, educational level, occupation, income, presence of underlying disease, and location (p &lt; 0.05). The number of sources of information on COVID-19 had a positive correlation with the STAI-6 score (Spearman’s rho = 0.176, p &lt; 0.001). The influence of the pandemic was correlated with moderate–severe anxiety. A high level of anxiety added to social anxiety (Spearman’s rho = 0.04, p &lt; 0.05) and discriminatory behavior (Spearman’s rho = 0.11, p &lt; 0.01). Being female (Estimate = 0.926) and from a non-emergency area (Estimate = −0.308) was related to higher STAI scores, and higher education (Estimate = −0.305), and income (Estimate = −0.168) decreased the STAI score. The respondents who had a lower evaluative score of the preventive activities undertaken by the national and local governments had higher STAI-6 scores.ConclusionOur findings provide statistical evidence for the associated reaction of anxiety and that anxiety reactions may vary in predictable ways. Further studies should focus on the strategic interventions that may decrease the associated responses to anxiety, to address mental health issues due to the pandemic.
Psychosocial Experiences of Older Women in the Management of Urinary Incontinence: A Qualitative Study
Authors: Javanmardifard Sorur , Gheibizadeh Mahin , Shirazi Fatemeh , Zarea Kourosh , Ghodsbin Fariba 
Published: March 2022

IntroductionUrinary incontinence is a prevalent disorder amongst older women. Identifying the psychosocial experiences of older women in disease management can improve the patient care process. Hence, the present study aimed to determine the psychosocial experiences of older women in the management of urinary incontinence.MethodsThis qualitative study was conducted using conventional content analysis. The study data were collected via unstructured in-depth face-to-face interviews with 22 older women suffering from urinary incontinence selected via purposive sampling. Sampling and data analysis were done simultaneously and were continued until data saturation. The interviews were recorded, transcribed, and analyzed using the method proposed by Graneheim and Lundman.ResultsThe results indicated that the older people with urinary incontinence had various psychosocial experiences while living with and managing this disease. Accordingly, four main themes were extracted from the data as follows: “problem incompatibility with the disease,” “mental impasse,” “facing social restrictions,” and “concealment and social escapism.”ConclusionThe findings demonstrated that older people with urinary incontinence experienced significant psychosocial pressures while living with this disorder, which affected their psychosocial well-being. Thus, paying attention to these psychosocial experiences while supporting and taking care of these patients can positively impact their psychosocial health and quality of life.
Interactive Effects of Agitation and Cognitive Impairment on Odor Identification in Patients With Late-Life Depression
Authors: Zhang Si , Chen Ben , Zhong Xiaomei , Zhang Min , Wang Qiang , Wu Zhangying , Hou Le , Zhou Huarong , Chen Xinru , Liu Meiling , Yang Mingfeng , Lin Gaohong , Hummel Thomas , Ning Yuping 
Published: March 2022

BackgroundLate-life depression (LLD) is a risk factor for cognitive decline in older adults, and odor identification (OI) deficits are an early indicator of cognitive decline with LLD. However, neuropsychiatric symptoms (NPSs) are common in LLD and are associated with OI deficits. In subjects with LLD, when OI deficits forecast cognitive decline, whether and how NPS affects the relationship between OI and cognition still must be further explored.ObjectiveTo comprehensively explore the potential effects of various NPSs on the relationship between OI and cognition in participants with LLD.MethodsThere were 167 patients with LLD and 105 normal elderly (NE) participants. The odor identification test (Sniffin' Sticks), cognitive function assessments (global cognition, memory, executive function, attention, language, visual space), and an NPS assessment (the neuropsychiatric inventory questionnaire) were performed on the subjects. In patients with LLD, the relationship among OI, cognition and NPSs was examined using correlation analysis and moderation analysis.ResultsIn patients with LLD, OI was positively correlated with cognition (global cognition, memory, executive function, attention, language) and negatively associated with NPSs (agitation and aberrant motor behavior). In NE group, OI was correlated with executive function. Moderation analysis showed that there was an interactive effect of agitation and cognitive impairment (language deficit or attention deficit) on OI in patients with LLD.ConclusionThe coexistence of agitation and language or attention deficit was associated with worse OI in subjects with LLD. Agitation should be considered since OI predicts cognitive decline in patients with LLD.
Impact of Parents' Oral Health Literacy on Their Own and Their Children's Oral Health in Chinese Population
Authors: Wang Yu , Inglehart Marita R. , Yuan Chao 
Published: March 2022

BackgroundOral health literacy (OHL) has been recognized as a component of oral health disparities; however, the precise relationship between literacy and oral health outcomes has not been established. To explore the role of parents' OHL for their own subjective oral health, related behavior, and for the proxy assessment of their child's oral health, oral health-related behavior.MethodsSurvey data were collected from 406 parents of 4- to 7-year-old children in Beijing, China. The background characteristics, oral health assessment, oral health-related behavior, knowledge and attitudes, and diet-related questions of parents and their children were surveyed by a questionnaire. OHL was assessed with the Hong Kong Rapid Estimate of Adult Literacy in Dentistry (HKREAL-30) Scale and a revised version that asked the respondents to indicate if they understood the words (HKREALD-30-Understand).ResultsThe HKREALD-30 responses correlated with the HKREALD-30-Understand responses. The higher the parents' HKREALD-30-Understand scores, the better they described the health of their own teeth and gums, the greater their child's diet was influenced by the protein, sugar and calories of the food, and the more positive their oral health-related attitudes were. The higher the parent's HKREALD-30 scores, the healthier they described their child's teeth and gums.ConclusionsBoth the HKREALD-30 and HKREALD-30-Understand Scores correlate with parents' self and proxy oral health-related responses. Chinese parents could understand that the word would add predictive value to the prediction of how parents' oral health literacy affects their own oral health care, children's oral health and other related aspects.
Measuring Attentional Distraction in Children With ADHD Using Virtual Reality Technology With Eye-Tracking
Authors: Stokes Jared D. , Rizzo Albert , Geng Joy J. , Schweitzer Julie B. 
Published: March 2022

Objective: Distractions inordinately impair attention in children with Attention-Deficit Hyperactivity Disorder (ADHD) but examining this behavior under real-life conditions poses a challenge for researchers and clinicians. Virtual reality (VR) technologies may mitigate the limitations of traditional laboratory methods by providing a more ecologically relevant experience. The use of eye-tracking measures to assess attentional functioning in a VR context in ADHD is novel. In this proof of principle project, we evaluate the temporal dynamics of distraction via eye-tracking measures in a VR classroom setting with 20 children diagnosed with ADHD between 8 and 12 years of age.Method: We recorded continuous eye movements while participants performed math, Stroop, and continuous performance test (CPT) tasks with a series of “real-world” classroom distractors presented. We analyzed the impact of the distractors on rates of on-task performance and on-task, eye-gaze (i.e., looking at a classroom whiteboard) versus off-task eye-gaze (i.e., looking away from the whiteboard).Results: We found that while children did not always look at distractors themselves for long periods of time, the presence of a distractor disrupted on-task gaze at task-relevant whiteboard stimuli and lowered rates of task performance. This suggests that children with attention deficits may have a hard time returning to tasks once those tasks are interrupted, even if the distractor itself does not hold attention. Eye-tracking measures within the VR context can reveal rich information about attentional disruption.Conclusions: Leveraging virtual reality technology in combination with eye-tracking measures is well-suited to advance the understanding of mechanisms underlying attentional impairment in naturalistic settings. Assessment within these immersive and well-controlled simulated environments provides new options for increasing our understanding of distractibility and its potential impact on the development of interventions for children with ADHD.
The use of Massive Online Games in game-based learning activities
Authors: Hernández Lorena , Hernández Verónica , Neyra Farah , Carrillo Julieta 
Published: March 2022

The popularity of massively multiplayer online games such as Minecraft and Roblox has aroused the attention of teachers and educational researchers in the past decade. The purpose of this paper is to provide preliminary classroom experience using Roblox in game-based learning activities through action research. Convenience and quota sampling were used, intervening in four groups from different educational levels: 1 secondary, 1 high school, and 2 colleges. The learning activities with Roblox were conducted during the 2020-2021 academic year during the COVID-19 pandemic that forced Mexican schools to go digital. Roblox was used to learn content (like dinosaurs, contagious diseases, system definition) and interpersonal skills (negotiation, cooperation). The participants’ learning perception was explored through quantitative and qualitative data. Findings suggest that students enjoyed the Roblox learning activity as it allowed social interaction between classmates. The students evaluated the learning through the Roblox activity class on different scales (3,08; 3,18; 4,07 and 4,21 on the Likert scale). The results indicate that there are generational differences between groups. Finally, the paper offers concrete suggestions for the use of Roblox in the educational context.
Penyelesaian Sengketa Dalam Perspektif Antropologi Hukum
Authors: Ilham Muhammad , Taufiq M 
Published: March 2022

The purpose of this paper is to find a meeting point for the study of legal anthropology in national law that has been in effect in Indonesia. Indonesia's plural society makes it richer in terms of prevailing customs. Of course, each custom has its own ways and criteria for establishing and compiling norms that apply in society. This, as the National law, as the unifier of the prevailing laws in society, certainly seeks to make absolute provisions and implement justice.
This study seeks to find common ground for these matters, so that the study used is a qualitative approach by suggesting the normative side of legal settlement that applies in society.
The results of this study found that there is a meeting point in the study of legal anthropology if it is related to the concept of national law. This effort, of course, must be understood by law enforcers so that every dispute can be preceded by an anthropological aspect of law. This action is expected to have a side of justice that will emerge so that every problem will be able to be resolved.
Strategi Pengembangan Pariwisata Indonesia Bagi Para Investor Pemula
Authors: Nexen Alexandre Pinontoan  
Published: March 2022

Pariwisata pada saat ini, mengalami dampak yang cukup signifikan dengan ada pandemi Covid-19. Di mana para pelaku bisnis pariwisata, mulai dari pengelola tempat wisata, travel agent, tempat penginapan sampai dengan para pelaku usaha UMKM yang berada di lokasi wisata mengalami kerugian yang cukup besar. Berbanding terbalik ketika saat sebelum pandemi terjadi, di mana sektor pariwisata merupakan salah satu sumber pendapatan yang sangat startegis. Oleh karena itu, banyak para pelaku usaha di sektor pariwisata “gulung tikar” untuk menutup bisnis yang mereka lakukan. Oleh Karena hal itu, dibutuhkan kerjasama yang itensif dari berbagai sektor, mulai dari pemerintah pusat, Pemerintah daerah, Pemerintah kabupaten sampai dengan para investor yang terlibat dalam hal ini, agar wisatawan lokal dan mancanegara tertarik berkunjung kembali untuk melihat dan menikmati objek wisata yang ada di Indonesia. Investor pemula merupakan salah satu ujung tombak bagi pengembangan pariwisata, mereka merupakan yang akan menjadi mitra pemerintah terkait yang berperan penting pengelolaan destinasi wisata. Oleh karena itu investor pemula dapat mengatur, bahkan memiliki obek wisata tersendiri, sehingga melahirkan pariwisata berbasis masyarakat. Kegiatan pengabdian ini berupa pelatihan yang disampaikan melalui metode ceramah dan diskusi dengan para investor pemula maupun para penggiat pariwisata. Alasan peserta ini dipilih karena pada umumnya para investor pemula dan penggiat wisata ini diproyeksikan sebagai sekelompok orang yang dapat memajukan kepariwisataan serta dapat meningkatkan kesejahteraan para masyarakat di sekitar objek pariwisata. Tujuan pelatihan ini adalah untuk mendapatkan pengembangan pengetahuan, penanaman konsep di bidang pariwisata. Pelatihan ini dilakukan untuk mendapatkan pengembangan pengetahuan, penanaman konsep di bidang pariwisata. Dengan pemaparan materi terdiri dari Potensi Bisnis Wisata, Tantangan External, Tantangan Internal. Hasil dari kegiatan ini ialah pengembangan pengetahuan, penanaman konsep di bidang pariwisata terkait dengan potensi bisnis wisata, tantangan eksternal dan tantangan internal. Sehingga bisa dikembangkan secara maximal oleh para investor pemula ataupun penggiat wisata.
Edukasi tentang Bagaimana Cara Mencegah Dan Menanggapi Covid-19 di Panti Yatim Indonesia Cabang Kota Tangerang
Authors: Nawiroh Vera  , Oxa Jemie Aditya  , Shintia Maulina  , Rifqa Alya Salsabila  , Resti Melliza Andinie  , Misbahul Anam  
Published: March 2022

Pengabdian kepada masyarakat ini dilaksanakan di Panti Yatim Indonesia cabang Kota Tangerang dengan tujuan memberikan pemahaman tentang bagaimana cara mencegah dan menanggapi virus covid-19. Kegiatan pengabdian ini menggunakan metode pelaksanaan pendekatan komunikasi persuasif. Kami berusaha memberikan informasi seputar pandemi covid-19 dan juga cara pencegahannya. Tak hanya pemberian informasi kami juga saling bertukar pikiran dan informasi pada teman teman kami di Panti Yatim Indonesia Cabang Kota Tangerang. Adapun luaran dari hasil pengabdian adalah; Anak panti mendapatkan pengetahuan tentang penjelasan virus covid-19. Anak panti mengetahui dan memahami tentang bagaimana cara pencegahan terkait covid-19. Anak panti menjadi lebih waspada dan berhati hati dengan adanya pandemi covid-19.
Persepsi Mahasiswa Program Studi Ekonomi Pembangunan Universitas Trilogi Terhadap Program Merdeka Belajar Kampus Merdeka (MBKM)
Authors: Panjaitan Mangasi , Rini Ayu Dwidyah , Agusalim Lestari , Abdullah Zed , Purwandaya Budhi , Pasaribu Benny 
Published: March 2022

Program Merdeka Belajar Kampus Merdeka (MBKM) Yang diluncurkan pada tahun 2020 memberikan warna tersendiri bagi pendidikan Indonesia, khususnya bagi mahasiswa perguruan tinggi. Program ini memberikan keleluasaan bagi mahasiswa untuk mememilih mata kuliah dan kampus yang diinginkan untuk pengembangan dirinya. Mahasiswa diberi hak untuk untuk kuliah tiga semester di luar program studinya didalam kampusdan/atau di luar kampusnya. Dalam pelaksanaannya program MBKM mengalami beberapa kendala. Kendala bisa berasal dari mahasiswa, kampus maupun pemerintah. Melaksanakan program “baru” yang berskala nasional tidaklah mudah. Pemerintah menyiapkan sarana dan prasana, SDM dan aturan pendukungnya. Kampus mempersiapkan dan menyesuaikan kurikulumnya dengan program MBKM dengan tetap mempertahankan capain pembelajaran dan profil lulusan program studi, mahasiswa belum sepenuhnya memahami program MBKM tersebut sebagai akibat kurangnya sosialisasi dan lemah iterasi mahasiswa untuk mencari informasi terkait. Bahkan sebagian mahasiswa tidak tahu adanya program tersebut. Mahasiswa punya persepsi bahwa program MBKM penting bagi mereka untuk meningkatkan kompetensi sebagai bekal menghadapi masa depan di dunia kerja. Mereka berharap adanya dukungan penuh dari kampus, dosen ketika akan mengikuti program MBKM. Namun mereka khawatir akan adanya biaya tambahan yang harus dikeluarkan ketika mengikuti program MBKM tersebut.
APOGEE Net: An Expanded Spectral Model of Both Low-mass and High-mass Stars
Authors: Sprague Dani , Culhane Connor , Kounkel Marina , Olney Richard , Covey K. R. , Hutchinson Brian , Lingg Ryan , Stassun Keivan G. , Román-Zúñiga Carlos G. , Roman-Lopes Alexandre , Nidever David , Beaton Rachael L. , Borissova Jura , Stutz Amelia , Stringfellow Guy S. , Ramírez Karla Peña , Ramírez-Preciado Valeria , Hernández Jesús , Kim Jinyoung Serena , Lane Richard R. 
Published: March 2022

Abstract
We train a convolutional neural network, APOGEE Net, to predict T
eff,

log
g

, and, for some stars, [Fe/H], based on the APOGEE spectra. This is the first pipeline adapted for these data that is capable of estimating these parameters in a self-consistent manner not only for low-mass stars, (such as main-sequence dwarfs, pre-main-sequence stars, and red giants), but also high-mass stars with T
eff in excess of 50,000 K, including hot dwarfs and blue supergiants. The catalog of ∼650,000 stars presented in this paper allows for a detailed investigation of the star-forming history of not just the Milky Way, but also of the Magellanic clouds, as different type of objects tracing different parts of these galaxies can be more cleanly selected through their distinct placement in T
eff–

log
g

parameter space than in previous APOGEE catalogs produced through different pipelines.