bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Salt-tolerant Traditional Rice Varieties in Mekong Delta, Vietnam
Authors: Duy Pham Vu Khuong , Lien Quan Thi Ai 
Published: April 2022

Abstract
Background: This study evaluated seedling stages’ salt tolerance in nutrient solution using three electrical conductivity (EC) salt concentrations of 9,38, 12,50, and 15,63 dS/m with fifteen traditional rice varieties. Methods and Results: Five traditional salt-tolerant rice varieties at the seedling stage (level 5) at 15,63 dS/m were selected. Furthermore, we evaluated salt tolerance at EC 9,38, 12,50, and 15,63 dS/m in the vegetative and reproductive stages of seven rice varieties (a tolerant variety, Doc Phung, a sensitive variety, IR28, and five rice salt-tolerant varieties were selected at seedling stage). Doc Phung was found to be salt tolerant, and IR28 was sensitive. This study showed that an increase in EC concentrations in the soil significantly reduced plant height, panicle/plant, panicle length, a 1000 grain weight, and yield. The addition of 9,38 dS/m EC can distinguish tolerance and sensitive genotypes. The grain yield of sensitive genotypes decreased by 90%–100% at 9,38 dS/m EC, whereas the tolerant genotypes showed <60% in grain yield reduction. Selected traditional rice varieties of Nang Cha Ran, Nep Than, Trang Lun, Gie Hanh, and Nang Tich were salt tolerant at their seedling stage. Vegetative and reproductive stages were at EC 9,38 dS/m. Conclusion: Salt inhibited the growth of five traditional rice varieties from vegetative to reproductive stages, thereby reducing plant height, panicle/plant, panicle length, and a 1000-grain weight and yield.
An endogenous CCL21-Ser deficiency reduces melanoma growth by an enhanced antitumor immunity
Authors: Fujie Ryonosuke , Kurowarabe Kaoru , Yamada Yuki , Fujiwara Kakeru , Hayashi Ryota , Kawahata Hinami , Miyamoto Megumi , Takahama Yousuke , Ohigashi Izumi , HAYASAKA HARUKO 
Published: April 2022

Abstract
The chemokine CCL21 regulates immune and cancer cell migration through its receptor CCR7. The Ccl21a gene encodes the isoform CCL21-Ser, predominantly expressed in the thymic medulla and the secondary lymphoid tissues. In this study, we used Ccl21a-knockout (KO) mice to examine the roles of CCL21-Ser in the antitumor immune response. We found that the KO mice had significantly decreased melanoma growth and increased CD8 T cell infiltration compared with the wild-type mice. The tumor in KO mice had a higher number of Tregs but no positive correlation existed between tumor weight and Treg/activated CD8 T cell ratio. The enhanced CD8 T cell antitumor immunity in the Ccl21a-KO mice demonstrates a functional contribution of endogenous CCL21-Ser to melanoma proliferation in vivo.
Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life
Authors: Cangiano Biagio , Giusti Emanuele , Premoli Caterina , Soranna Davide , Vitale Giovanni , Grottoli Silvia , Cambria Valeria , Mantovani Giovanna , Mungari Roberta , Maffei Pietro , Dassie Francesca , Giampietro Antonella , Chiloiro Sabrina , Tanda Maria Laura , Ippolito Silvia , Cannavò Salvatore , Ragonese Marta , Zambon Antonella , Persani Luca , Fatti Letizia Maria , Scacchi Massimo 
Published: April 2022

Abstract
Purpose
Current treatment of acromegaly restores a normal life expectancy in most cases. So, the study of persistent complications affecting patients’ quality of life (QoL) is of paramount importance, especially motor disability and depression. In a large cohort of acromegalic patients we aimed at establishing the prevalence of depression, to look for clinical and sociodemographic factors associated with it, and to investigate the respective roles (and interactions) of depression and arthropathy in influencing QoL.
Methods
One hundred and seventy-one acromegalic patients (95 women and 76 men, aged 20–85 years) among those recruited in a cross-sectional Italian multicentric study were investigated. Each patient filled in three validated questionnaires: AcroQoL, WOMAC (measuring articular pain, stiffness and functionality), and AIMS (evaluating articular symptoms and depression).
Results
a very high (up to 28%) depression rate was detected in acromegalic subjects. Two patients showing pathological AIMS depression scores, committed suicide during the three years observational period. In our population poor psychological status was significantly associated with female sex. Furthermore, a significant strong correlation was found between AIMS depression score and WOMAC score. Both depression and arthropathy-related motor disability turned out to independently contribute with similar strength to the impairment of QoL.
Conclusions
We report a high prevalence of depression in acromegaly, which is associated with female sex and arthropathy. Both depression and arthropathy strongly and independently contribute to the impaired QoL of patients. Our study shows that assessment and monitoring of psychological status is mandatory in acromegaly, also suggesting an inexpensive tool for this assessment.
Global Burden of Alzheimer's disease and other dementias and Attributable to Risk factors, 1990–2019: An Analysis Based on the Global Burden of Disease Study 2019
Authors: cui yiran , yang wenyan , shuai jingliang , ma yulan , yan yan 
Published: April 2022

Abstract
Background
The exposure to risk factors (Smoking, High fasting plasma glucose and High BMI) are considered a major health concern. However, previous studies focused on changes in the global age-specific incidence and mortality, failed to distinguish between cohort and period effects, and did not discuss risk factors separately.
Methods
This study to estimate the burden of Alzheimer's disease and other dementias stratified by gender, age, locations, and social-demographic status for 21 regions across the world from 1990 to 2019. Besides, trend analyzes were conducted for major regions and risk factors for DALYs were also analyzed using age-period-cohort model and Join-point model.
Results
Globally, the age standardized incidence rate(ASIR), age standardized death rate(ASDR), and age standardized DALY rates for Alzheimer's disease have an upward trend from 1990 to 2019.(percentage change: 1.5%,3.0%,3.5%, respectively) with average annual percent change. In most regions, indicators (incidence, mortality, and DALYs) increased steadily with SDI increased. By APC analysis, substantially increasing age effects were presented for Alzheimer's disease and other dementias from 40 to 95 years. The cohort effects RRs had a rapid reduction attribute to Smoking, High fasting plasma glucose and High BMI.
Conclusions
As the burden of Alzheimer's disease remains high in areas with low SDI. Therefore, rapid and effective government responses are needed to tackle and control dementia risk factors to reduce the disease burden in middle-low and low SDI countries.
Optical properties and complex refractive index of Co doped ZnO waveguide thin films elaborated by spray pyrolysis
Authors: DJAABOUBE Halima , MAMMERI Abdelouadoud , Bouachiba Yassine ,   Adel TAABOUCHE1, BOUABELLOU Abderrahmane ,   Hacene SERRAR3, Sekhri Ilyes , RAHAL Badis 
Published: April 2022

Abstract

CoxZn1-xO (x = 0.00, 0.04, 0.08 and 0.10) thin films were sprayed pyrolysis onto ordinary glass substrates. The micro Raman spectroscopy revealed the presence of wurtzite structure in all films. The UV-Vis investigation showed good optical transmittance in the visible region with the increase in the absorption bands related to internal Co+2 d-d transitions over Co concentration. The optical gap energy decreased by 0.34 eV as Co doping increased, contrary to Urbach energy which increased by 230 meV. The SEM observation indicated obvious modification in the morphology of the films. M-lines spectroscopy measured the ordinary refractive index which was found to increase by 0.0156 as the Co doping increased. Cobalt doping provoked the extinction of light coupling and propagation in the films manifested as an increase in full width at the half maximum of the guided peaks and a decrease in the reflected intensity. This was due to the increase in the extinction coefficient measured by UV-Vis spectroscopy.
SMART - A Tool Kit for Sustainable Method of Agriculture Using Root Transition
Authors: Acharya Aniruddha 
Published: April 2022

Abstract
The rapid increase in global population along with urbanization will continue to increase the challenge of food security and environmental sustainability. Agriculture is essential for food security, however, is an expensive process both financially and environmentally. Estimation of crop performance before investing in field would substantially benefit agricultural output and environmental sustainability. A simple, easy to use, portable, and inexpensive prototype of a device is described that can be successfully used to estimate plant performance and help tailor fertilizer formulations and microbial consortium for optimal agronomic output. The device can also be used for agriculture by farmers and for plant research by students and scientists.
Evolutionary mechanisms and shifting trends in water circulation patterns in a tributary of the Three Gorges Reservoir, China
Authors: Ijaz U. , Cheng Z. , Qiu S. , Ayub H. 
Published: April 2022

Abstract
A 2-D CE-QUAL-W2 hydrodynamic model was established to simulate evolutionary mechanisms and shifting trends of flow patterns per annum and over seasons from 2008 to 2018 in a reflective tributary Xiangxi Bay (XXB) of the Three Gorges Reservoir, China. Reasons behind shifting trends of flow patterns were also investigated. Model performance was validated and simulated data was synchronous to observed data. In general, percentage of Pattern (6) was 14%, 20%, 17%, 12% and 11% per annum and in spring, summer, autumn and winter respectively by 2013. It was increased by 26%, 30%, 22%, 25% and 35% per annum and in spring, summer, autumn and winter respectively since 2014. Increased temperature and flow dynamics (such as 10,000 m3 s−1 in spring) in Three Gorges Resevoir (TGR) since 2014 were underlying shifting trends of density current patterns. Correlation among patterns prior to and after newly built upstream reservoirs was novel and innovative in finding hydrodynamic thresholds to increase effectivity. Particulars elaboated and associated with respective density current patterns indicate increased surface velocity and water exchange with increased overflows. This could help understanding hydrodynamics and ecological variations in TGR and XXB. Thermal establishment and flow dynamics in TGR triggering overflow intrusion in XXB are required to be achieved. A hydrodynamic and water quality model of XXB coupled with TGR mainstream is recommended to correlate additive impacts of advantageous and disadvantageous patterns and to evaluate hydrodynamical thresholds triggering advantageous patterns in XXB.
Local Delivery of Metronidazole-loaded N-Trimethyl Quaternary Ammonium
Chitosan Nanoparticles for Periodontitis Treatment
Authors: Garg Kritika , Tirgar Pravin 
Published: April 2022

Background:
Recent findings suggest that chitosan has shown antibacterial activity acting
through various mechanisms, but when the amine group in chitosan is converted to quaternary ammonium
compound, the antibacterial activity of chitosan is elevated due to the increase in its solubility in
an acidic environment.

Objectives::
The purpose of this study was to formulate and standardize metronidazole-loaded Ntrimethyl
quaternary ammonium chitosan nanoparticles for the treatment of periodontitis.

Method:
N-trimethyl quaternary ammonium chitosan derivative was synthesized, and nanoparticles
(NPs) were prepared by ionic gelation methodology followed by 32 full factorial designs. Particle size,
zeta potential, polydispersity index (PDI), surface morphology, thermal properties, in vitro drug release
as well as antimicrobial activity, stability study, ex vivo, and acute toxicity of NPs were evaluated.

Results:
The optimized batches of NPs were in the size range of 150 to 237 nm with a mean size of
117.01 ± 0.03 nm. Entrapment efficiency (EE) of 81.45 ± 0.03 % was obtained with a zeta potential
(mV) of 28.19 ± 0.03 mV. Almost 98.97 ± 7.17% of the drug was released within 24 hours in vitro to
obtain a sustained release drug; the optimized batches exhibited a smooth surface with appreciable in
vitro, ex vivo antibacterial, and acute toxicity, and it was found that the formulation could be stored for
up to 6 months.

Conclusion:
The present study revealed that metronidazole-loaded N-trimethyl quaternary ammonium
chitosan nanoparticles exhibit enhanced antibacterial activity against periodontal infections.
Does Gut-breast Microbiota Axis Orchestrates Cancer Progression?
Authors: Marino Maria Michela , Nastri Bianca Maria , D’Agostino Marina , Risolo Rossella , De Angelis Alessandra , Settembre Giuliana , Rienzo Monica , D’Esposito Vittoria , Abbondanza Ciro , Formisano Pietro , Ballini Andrea , Santacroce Luigi , Boccellino Mariarosaria , Di Domenico Marina 
Published: April 2022

Abstract:
Breast cancer, even today, can cause death. Therefore, prevention and early detection
are fundamental factors. The mechanisms that favour it are genetic and epigenetic, and seem to
play a significant role; also, the microbiota can change estrogen levels and can induce chronic
inflammation in the neoplastic site, alternating the balance between proliferation and cell death.
Activated steroid hormone receptors induce transcription of genes that encode for proteins involved
in cell proliferation and activate another transduction pathway, inducing cell cycle progression
and cell migration. These important studies have allowed to develop therapies with selective
modulators of estrogen receptors (SERMs), able to block their proliferative and pro-tumorigenic
action. Of fundamental importance is also the role played by the microbiota in regulating
the metabolism of estrogens and their levels in the blood. There are microbial populations
that are able to promote the development of breast cancer, through the production of enzymes
responsible for the deconjugation of estrogens, the increase of these in the intestine, subsequent
circulation and migration to other locations, such as the udder. Other microbial populations are,
instead, able to synthesize estrogen compounds or mimic estrogenic action, and interfere with the
metabolism of drugs, affecting the outcome of therapies. The microbial composition of the intestine
and hormonal metabolism depend largely on eating habits; the consumption of fats and proteins
favours the increase of estrogen in the blood, unlike a diet rich in fiber. Therefore, in-depth
knowledge of the microbiota present in the intestine-breast axis could, in the future, encourage
the development of new diagnostic and therapeutic approaches to breast cancers.
A Kind of Electro-hydraulic Servo System Cooperative Control Simulation:
An Experimental Research
Authors: Gao Bingwei , Shen Wei , Dai Ye , Wang Wei 
Published: April 2022

Background:
The single position control or force control of the electro-hydraulic servo
system has long been unable to meet the actual needs of production and life. To achieve a good control
effect and solve various problems in real life, people no longer only consider a single position
control or force control.

Objective:
The proposed method provides technical support for multi-objective collaborative control
of the electro-hydraulic servo system, completes the requirements of multitasking operation, improves
the positioning accuracy and response velocity of the electro-hydraulic servo system, and
realizes the synergy between the position and force.

Methods:
A control method of the outer loop control of force as feedforward compensation is
adopted to realize the coordinated control of force and position based on position control. The position
control part adopts the PID control algorithm to ensure real-time response accuracy and positioning
accuracy. The outer force loop uses an adaptive fuzzy neural network control algorithm to
reduce vibration and shock caused by system instability and nonlinear factors during the force control
process.

Results:
The control effect of the designed position/force collaborative controller is verified by simulation
and experiment. It can effectively reduce the vibration and impact caused by the contact
force during the working process of the system, at the same time greatly improving the accuracy of
position control and improving the stability of the system.

Conclusion::
The designed force/position collaborative control system has a good overall control
effect.
IMPLEMENTASI PROGRAM LAYANAN MUTASI SISWA SD DAN SMP DALAM PELAYANAN TERPADU SATU PINTU DI DINAS PENDIDIKAN PEMUDA DAN OLAHRAGA KOTA YOGYAKARTA
Authors: Septyaningsih Rimawati 
Published: April 2022

This study aims to describe the implementation as well as the supporting and inhibiting factors of the transfer service program for elementary and junior high school students in PTSP at Disdikpora Yogyakarta City. The type of research used is descriptive with a qualitative approach. The results obtained are: (1) Implementation of the student transfer service program at the Disdikpora Yogyakarta City: a) The standard of mutation service is the value of students and the availability of class formations at the target school and the target is the community who wants to apply for a student transfer application. b) Resources in the form of 4 implementing officers from the Junior High School Development Division and Elementary School Development staff and adequate facilities. c) The characteristics of the organization are nimble and able to work well together. d) Relationships between organizations run with communication and coordination during service delivery. e) Environmental conditions are mutually supportive. f) Disposition is reflected in the capability of the executing agent. (2) The supporting factors are complete facilities, adequate human resources, and easy and clear administrative processes. The inhibiting factors a) Officers who are still double jobs so they cannot focus on student transfer services. b) Implementation of mutation services that cannot be carried out fully online. c) The file processing flow is still quite time consuming because of the manual numbering system. d) Not updating the field header for the files that enter the system. Keywords: Implementation, Student Mutation, Disdikpora Yogyakarta City
ANALISIS TREN ANGKA PUTUS SEKOLAH PADA PENDIDIKAN DASAR DI KABUPATEN BANTUL
Authors: Widyastuti Nur Aini 
Published: April 2022

The purpose of this study are: to describe the tren of children’s dropping out rates from primary education, describe the factors that influence the change in the tren line of children dropping out of school in primary education in Bantul Regency, and describes policies and follow-up actions taken by the government to reduce dropout rates in Bantul Regency. This research is a descriptive quantitative research. The data was obtained from the Dikpora Bantul and analyzed with the least squares trend. The results of this study are: 1. At elementary level (SD/MI) in Bantul Regency, there is an increasing tren and has not reached 0%. At junior high level (SMP/MTs), there is a decreasing tren and has been reached 0%. 2. The results of tren analysis are influenced by internal and external factors that cause children to drop out of school; 3. Policy in the Elementary School sector, namely to activate compulsory education programs, social assistance, and inclusive schools. Follow-up in the SD sector by increasing public awareness, collaboration with various cross-agency. The SMP sector carries out a policy of completing the 9-year compulsory education program, simultaneous assistance, and tracing to the village level. Follow-up in the field of SMP by increasing Minimum Service Standards, maximizing support capacity, and discussing with Commission D. Keywords: Trens, Dropout Rate, Primary Education, Bantul Regency
IMPLEMENTASI PROGRAM EDUCATION FOR SUSTAINABLE DEVELOPMENT DI SMA TUMBUH
Authors: Primasti Shelma Ghusa 
Published: April 2022

Penelitian ini bertujuan menganalisis dan mendeskripsikan implementasi program Education for Sustainable Development (ESD serta faktor pendukung dan penghambatnya di SMA Tumbuh. Jenis penelitian ini studi kasus dengan pendekatan kualitatif. Partisipan penelitian adalah kepala sekolah, koordinator kurikulum, guru permakultur, seni rupa, pendidikan pangan, Person in Charge (PIC) program magang dan mangrove planting, peserta didik SMA Tumbuh. Teknik pengumpulan data dengan observasi, wawancara, dokumentasi. Teknik analisis data dengan kondensasi data, penyajian data, penarikan kesimpulan. Uji keabsahan data dengan triangulasi teknik dan sumber. Hasil penelitian: ESD di SMA Tumbuh terintegrasi dalam mata pelajaran dan kegiatan. Implementasi program: komunikasi melalui sosialisasi terintegrasi dalam kegiatan pembelajaran, sumber daya manusia telah kompeten, perlu sumber daya manusia yang sesuai bidang keilmuan untuk permakultur, sumber daya anggaran dan fasilitas tersedia dan memadai, untuk permakultur masih perlu dipenuhi, disposisi program mendapatkan respon positif seluruh warga sekolah, struktur birokrasi melekat pada struktur organisasi sekolah. Faktor pendukung: dukungan berbagai pihak, koordinasi dan kolaborasi yang baik, sumber daya anggaran dan fasilitas, sekolah lebih menghargai peserta didik. Faktor penghambat: kondisi pandemi, sumber daya manusia untuk ESD lingkungan hidup belum sesuai bidang keilmuan, fasilitas mapel permakultur belum lengkap, hambatan cuaca, supervisor program magang belum secara penuh mengawasi siswa.
IMPLEMENTASI KEBIJAKAN PENDIDIKAN KARAKTER DI SMK NEGERI 2 DEPOK SLEMAN
Authors: Pratiwi Faridhatun Anisa 
Published: April 2022

Abstrak Penelitian ini bertujuan untuk mendeskripsikan tentang perumusan kebijakan pendidikan karakter di SMK N 2 Depok, pelaksanaan kebijakan pendidikan karakter, serta faktor pendukung dan penghambatnya. Penelitian ini merupakan penelitian deskriptitif kualitatif, dengan metode wawancara, observasi, dan studi dokumen. Hasil penelitian ini yaitu: 1) Perumusan kebijakan pendidikan karakter di SMK N 2 Depok dilakukan dengan tahap diskusi, dituangkan ke dalam program sekolah, dan sosialisasi yang sesuai dengan teori transaktif; 2) Kebijakan pendidikan karakter di SMK N 2 Depok diintegrasikan ke dalam kegiatan pengembangan diri dan ekstrakurikuler; 3) Faktor pendukung implementasi kebijakan pendidikan karakter di SMK N 2 Depok yaitu tersedianya sarana prasarana. Sedangkan faktor penghambatnya adalah keterbatasan waktu pelaksanaan program pendidikan karakter. Kata Kunci: kebijakan pendidikan karakter, implementasi kebijakan pendidikan karakter, faktor pendukung dan penghambat pendidikan karakter Abstracs This study aims to describe the formulation of character education policies at Depok N 2 Vocational School, the implementation of character education policies, as well as supporting factors and barriers. This research is a qualitative descriptive research, with the method of interviews, observation, and document study. The results of this study are: 1) The formulation of character education policies at Depok N 2 Vocational High School is carried out with the discussion phase, poured into school programs, and socialization in accordance with the transactive theory; 2) Policy on character education at Depok N 2 Vocational School is integrated into self-development and extracurricular activities; 3) Supporting factors for the implementation of character education policies at Depok N 2 Vocational School, namely the availability of infrastructure. While the inhibiting factor is the limited time for implementing a character education program. Keywords: character education policies, implementation of character education policies, supporting factors and barriers to character education