bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conjugated linoleic acid isomers induced dyslipidemia and lipoatrophy are exacerbated by rosiglitazone in ApoE null mice fed a Western diet
Authors: Chai Boon Kheng , Murugan Dharmani Devi , Rais Mustafa Mohd , Al-Shagga Mustafa , Mohankumar Suresh K. 
Published: February 2022

BACKGROUND: Insulin sensitizers have been used to treat Type 2 diabetes. However, their non-negligible side effects have led to cardiovascular concerns and the withdrawal of a member, rosiglitazone. OBJECTIVE: We combined conjugated linoleic acid (CLA) with rosiglitazone to test for amelioration of side effects posed by rosiglitazone in vivo. METHODS: We utilized ApoE null mice fed with Western diet (WD) to test our hypothesis. Mice were fed WD, with or without CLA administration, for 12 weeks. CLA utilized in our study consisted of a 1:1 ratio of 95% pure c9,t11, and t10,c12 isomers at a concentration of 0.1% w/v in fat-free milk. Starting from Week 12, select mice received rosiglitazone. RESULTS: It was found that mice receiving CLA from Week 0 and rosiglitazone from Week 12 had the lowest body weight and exacerbated hepatomegaly. Although these mice had attenuated insulin resistance compared to mice receiving only Western diet, they display a marked increase in total plasma cholesterol and low-density lipoprotein (LDL) cholesterol. Mice receiving early CLA administration developed hyperleptinemia, which was not restored by rosiglitazone. CONCLUSION: Taken together, against the background of ApoE null genotype and WD feeding, simultaneous administration of 1:1 CLA and rosiglitazone led to dyslipidemic lipoatrophy.
Using NIPAM gel dosimeter and concentric swing machine to simulate the dose distribu- tion during breathing: A feasibility study
Authors: Sun Jung-Chang , Hsieh Bor-Tsung , Cheng Chih-Wu , Hsieh Chih-Ming , Tsang Yuk-Wah , Cheng Kai-Yuan 
Published: February 2022

BACKGROUND: Radiotherapy plays an important role in cancer treatment today. Successful radiotherapy includes precise positioning and accurate dosimetry. OBJECTIVE: To use NIPAM gel dosimeter and concentric swing machine to simulate and evaluate the feasibility of lung or upper abdominal tumor dose distribution during breathing. METHODS: We used a concentric swing machine to simulate actual radiotherapy for lung or upper abdomen tumors. A 4 × 4 cm2 irradiation field area was set and MRI was performed. Next, readout analysis was performed using MATLAB and the 3 mm, 3% gamma passing rate > 95% was used as a basis for evaluation. RESULTS: The concentric dynamic dose curve for a simulated respiratory rate of 3 seconds/breath and 4 × 4 cm2 field was compared with 4 × 4, 3 × 3, and 2 × 2 cm2 treatment planning systems (TPS), and the 3 mm, 3% gamma passing rate was 42.87%, 54.96%, and 49.92%, respectively. Pre-simulation showed that the high-dose region dose curve was similar to the 2 × 2 cm2 TPS result. After appropriate selection and comparison, we found that the 3 mm, 3% gamma passing rate was 97.92% on comparing the > 60% dose curve with the 2 × 2 cm2 TPS. CONCLUSIONS: NIPAM gel dosimeter and concentric swing machine use is feasible to simulate dose distribution during breathing and results conforming to clinical evaluation standards.
Clinical value and application of preoperative CT-guided hookwire localization of solitary pulmonary nodules for video-assisted thoracic surgery
Authors: Yan Gen , Cheng Xiaofang , Wu Shuohua , Ge Yuxi , Li Shanhua , Xuan Yinghua 
Published: February 2022

BACKGROUND: Video-assisted thoracic surgery (VATS) is a minimally invasive technique for the diagnosis and management of small pulmonary nodular lesions However, the identification of some lung nodules remains difficult. OBJECTIVE: This research aimed to investigate the clinical value of preoperative computed tomography (CT)-guided hookwire localization of solitary pulmonary nodules (SPNs) for thoracoscopic resection. METHODS: Seventy-one patients with 74 SPNs underwent VATS wedge resection after CT-guided hookwire localization. The mean diameter of the SPNs was 8.50 ± 4.53 mm,,besides, the mean distance from the SPNs to the parietal pleura was 16.81 ± 5.23 mm. RESULTS: Sixty-nine of the 74 nodules were successfully localized using a CT-guided hookwire. The success rate of CT-guided localization was 93.2%. The average localization time was 15.23 ± 7.21 min per lesion. Seven patients (9.5%) had asymptomatic pneumothorax and 10 (13.5%) had minimal needle tract parenchymal hemorrhages after localization no clinical intervention was required for these patients. The rate of success for VATS wedge resection of the SPNs was 100%. Histological analysis of the SPNs revealed malignant disease in 67.4% of the patients. CONCLUSIONS: Preoperative CT-guided hookwire localization for thoracoscopic resection is a safe and effective operation for the identification and stable fixation of SPNs.
A felsőoktatási modellváltás tapasztalatai hallgatói szemszögből
Authors: Fodor Márk Joszipovics 
Published: February 2022

A magyar felsőoktatás modellváltása az elmúlt évek egyik legjelentősebb, egyben politikailag rendkívül konfliktusos strukturális reformja volt. A modellváltás hallgatói fogadtatása intézményenként eltérő volt, a közönytől kezdődően egészen az egyetemfoglalásig. Az új struktúra hatásai eltérő mértékben érvényesültek a különböző intézményekben, attól függően, hogy a modellváltás melyik szakaszában vettek részt a folyamatban, amelyet pedig nehezített a végrehajtás feszített ütemezése, valamint a koronavírus-járvány elleni védekezés keretében bevezetett atipikus oktatásra és működésre való átállás. A Budapesti Corvinus Egyetemen bekövetkezett strukturális változások, valamint a többi modellváltó intézményben megtörtént alacsonyabb mértékű lépések azonban fontos tapasztalatokkal szolgálnak a modellváltás további folyamatára nézve, noha átfogó értékelést ilyen rövid időtávlatban nem lehet végezni.
Peningkatan Self-Management Melalui Pendampingan Penyusunan Goal-Setting Dan Time-Management
Authors: Mahmudah Fitri Nur , Fatmawati Laila , Nafia Zidnii Iilma 
Published: February 2022

Memperhatikan kondisi alam dan perkembangan era yang tidak signifikan perubahannya berdampak pada aktivitas siswa. Begitu juga dampak pandemi covid-19 yang masih dirasakan oleh sebagian besar siswa yang mengikuti distance learning. Permasalahan yang muncul adalah banyaknya gangguan yang dihadapi oleh para siswa di luar jadwal sekolah sehingga siswa membutuhkan self-management yang baik. Tujuan pengabdian kepada masyarakat ini adalah untuk dapat meningkatkan self-management siswa melalui pendampingan dalam penyusunan goal setting dan time management. Metode pemecahan yang dilakukan dengan cara memberikan materi, praktik penyusunan, dan pendampingan siswa. Hasil temuan saintifik pengabdian kepada masyarakat ini adalah terkait dua komponen yaitu goal setting dan time management. Goal setting siswa terdiri dari empat komponen yaitu behavior, spirit, commtiment, dan progress. Sedangkan time management meliputi to do list, prioritize, dan self-evaluation. Simpulan pengabdian kepada masyarakat ini adalah pentingnya pemahaman siswa terkait temuan tersebut sehingga dapat dipraktikkan kedalam kehidupan sehari-hari dan pada akhirnya dapat meningkatkan kemampuan diri dalam mencapi prestasi belajar.
Avaliação química e microbiológica do óleo essencial de Cymbopogon densiflorus (Poaceae)
Authors: Fonseca Sarah Emidio , De Marco Janice Lisboa , Souza Silvia Ribeiro de 
Published: February 2022

A espécie Cymbopogon densiflorus, conhecida popularmente como capim caboclo, capim nagô é tradicionalmente utilizada contra resfriados, asma e infecções é originária da África e bem aclimatada no Brasil. O objetivo deste trabalho foi identificar os principais compostos do óleo essencial da inflorescência de C. densiflorus e avaliar sua atividade antimicrobiana frente a microrganismos patogênicos humanos. O óleo foi obtido por hidrodestilação em aparelho Clevenger modificado por 2 h. As amostras foram caracterizadas por cromatografia gasosa e os principais compostos identificados foram monoterpenos, ésteres de ácido graxo, álcoois e óxidos, sendo o limoneno o constituinte presente em maior quantidade (13,07%). A análise da atividade microbiológica do óleo essencial em diferentes concentrações (100%, 50% e 25%) evidenciou sua capacidade antimicrobiana avaliada pela efetividade na inibição do crescimento dos microorganismos, Bacillus sp., S. aureus, E. coli indicado por meio da formação de halos de inibição do crescimento com diâmetro igual ou superior a 10 mm. Estudos futuros são requeridos a fim de se investigar o potencial terapêutico e econômico do óleo de C. densiflorus para o tratamento de doenças microbianas como pneumonia, infecçoes cutâneas, Gastroenterite, cistite que acometem a população.
Inovação, sustentabilidade e difusão do conhecimento tradicional e científico
Authors: Bieski Isanete Geraldini Costa , Sacramento Henriqueta Tereza do 
Published: February 2022

É com muita alegria que estamos publicando no Suplemento da Revista Fitos artigos originários do 1º Congresso Internacional online de Fitoterapia (INTERPHYTO), que aconteceu de 09 a 13 de março de 2021, totalmente online, organizado pelo Instituto do Saber Ativo (ISA), com sede em Juína, Mato Grosso, Brasil.
Os objetivos do 1º INTERPHYTO foram: incentivar a extensão da linha de pesquisa científica, fomentar o estudo aprofundado, apoiar os debates teóricos investigativos, discutir acerca dos conhecimentos entre acadêmicos e profissionais de diversas áreas, apreciadas e relacionadas no desenvolvimento científico, e promover ambiente propício para a busca de resultados das pesquisas científicas.
O evento teve como tema principal “inovação, sustentabilidade e difusão do conhecimento tradicional e científico”, possibilitando agregar as riquezas nutricionais, medicinais e cosméticas das plantas medicinais, como principal fonte da biodiversidade para o fomento da bioeconomia no planeta.
Com 60 horas de Congresso o 1º INTERPHYTO contou com a participação de 1000 participantes e 45 palestrantes de 10 países, 150 pôsteres, palestra Magna, oficinas, minicursos e mesas redondas com três (3) apresentadores e um (1) coordenador..
Os trabalhos apresentados foram selecionados por uma Comissão Científica composta por mestres e doutores renomados na área das plantas medicinais e fitoterapia de diversas Universidades Brasileiras, nas diversas áreas do conhecimento, quais sejam: Agroecologia (Botânica; Cultivo e melhoramento; Biodiversidade e inovação; Bioeconomia e Redes Sustentáveis e afins); Ciências Farmacêuticas (Farmacognosia; Farmacotécnica; Análise e Controle de qualidade de medicamento e produtos; Farmacologia não-clínica e Clínica; Toxicologia e afins); Educação e Conhecimento, Etnociências (Etnobotânica; Etnofarmacologia e afins); Química de Produtos Naturais (Fitoquímica; Nanotecnologia; Metabolômica e afins) e Política e Gestão (Políticas Públicas; Política e Planejamento Governamental; Crescimento Econômico, Saúde Pública; Farmácia Viva e afins).
Este Suplemento é composto de artigos originais, abrangendo todas as áreas do conhecimento participantes do evento, que foram submetidos para o processo de revisão pelos pares e editoração da Revista Fitos.
Contudo, neste editorial, trazemos ao público a expressão mais concreta da relevância do 1º INTERPHYTO e a oportunidade de o leitor conhecer, por meio dos artigos que compõem esta publicação, as temáticas apresentadas e discutidas no evento.
Esperamos que os artigos deste suplemento contribuam para uma contínua e, cada vez mais aprofundada integração nacional e internacional, qualificada para o ensino e pesquisa de plantas medicinais.
Boa leitura a todos!
Nosso sincero Fito Abraços.
THE EFFECT OF WEB QUALITY ON CUSTOMER LOYALTY AND ITS IMPACT ON BANK PERFORMANCE
Authors: Teguh Iman Basuki  , Dwi Dita Rari 
Published: February 2022

In the era of the industrial revolution 4.0, consumer behavior in finding and obtaining information shifted from print media to be more dominant, using electronic media. The increase in the number of individual consumers in using it can be influenced by the quality of the website that can provide the information that customers need. Website quality is one determining factor whether consumers want to make transactions through the website, because consumers fully rely on the information owned by the website so that trust arises to decide to buy. For the banking industry, digital marketing is a reliable way because it is proven to be effective and efficient, especially through the website. Information on banking products can be presented, through the website, some transactions can be served well, this shows the quality of the website that is owned is very good and can be a factor driving customer loyalty by making repeated transactions using the website and will not be affected to switch to competitors. When customer loyalty is formed, it will certainly affect the performance of the bank because the company can make cost savings in getting new customers. It is an effective way to increase company profits. The results of the study have significance with p-value <0.01 so that there is a direct influence on web quality (X) on financial performance (Z) and there is no mediation through customer loyalty (Y) on financial performance (Z) because the p-value is greater than 0.01.
İSLAM SANATINDA SOYUTLAMA VE MEKÂN ALGISI
Authors: GENÇ Mehmet Ali 
Published: February 2022

Çok geniş coğrafyaya yayılmış olan İslâm sanatı alanında yeterince yayın bulunmasına karşılık İslâm sanatının iç anlamı ve biçim dili yönünden incelenmesinin yeterince yapılmadığı görülmektedir. Bu çalışmada, İslâm medeniyetinin görsel sanatlarına yansımış olan soyutlama ve mekân algısının irdelenmesi amaçlanmıştır.
Sanatın görsel biçim dili, mekân içinde ifade edilmektedir. Genel olarak dikey mekân ve yatay mekân olarak ayrılan bu mekânlara bakılarak sanatın köken ve aidiyeti hakkında fikir edinilebilmektedir. Fetihlerle farklı kültür ve medeniyetlerin sanat yaklaşımlarından yararlanarak yeni sentezlere ulaşmış olan İslâm medeniyeti, kendine has bir sanat grameri oluşturmuştur. Görülen gerçeğin ötesine geçmekte olan İslam sanatı, sade ve grafiksel bir soyutlamayı dikey bir mekân içinde göstermektedir. Sanata çoklu bakış ve çoklu zaman boyutu sağlayan dikey mekân, gerçeğin doğru ifade edilmesini sağlamaktadır.
Resistência de Staphylococcus aureus e Escherichia coli à antibióticos
Authors: Silva Sybelle Georgia Mesquita da , Melo Breno Araújo de , Santos Micheline Thais dos , Ribeiro Júnior Karlos Antônio Lisboa , Maranhão Fernanda Cristina de Albuquerque , Santos Tania Marta Carvalho dos , Fraga Angelina Bossi 
Published: February 2022

A mastite é uma das principais enfermidades que acomete o rebanho leiteiro, sendo causada por diversos micro-organismos dos quais se destacam as bactérias Staphylococcus aureus e Escherichia coli. O tratamento para esta enfermidade é realizado, geralmente, por meio do uso de antibióticos via intramamária. No entanto, o uso inadequado desses medicamentos tem contribuído para a seleção de cepas de micro-organismos resistentes, dificultando o tratamento e controle da mastite. Com isso, objetivou-se avaliar cepas das bactérias S. aureus e E. coli frente aos antibióticos: Florfenicol, Enrofloxacina, Gentamicina, Amicacina, Tetraciclina, Norfloxacina, Cefalotina, Cefalexina, Gentamicina, Neomicina, Amoxilina, Ampicilina + Sulbactam, Cefoxitina, Bacitracina, Ampicilina e Penicilina. As bactérias foram inoculadas em solução salina 0,9% e semeadas em 100 µL de meio Mueller Hinton com os discos de antibióticos. Os testes foram realizados em quadruplicata e as placas incubadas a 37°C durante 24h. Os resultados mostraram que S. aureus foi resistente a penicilina (10µg) e ampicilina (10µg), apresentando maior sensibilidade ao antibiótico florfenicol (30µg). A bactéria E. coli também apresentou maior sensibilidade ao florfenicol (30µg), sendo resistente à bacitracina (10µg). Nossos resultados indicaram que a investigação por novas alternativas para o tratamento da mastite é urgente e necessária.
Avaliação de escore de condição corporal e famacha em ovelhas suffolk a pasto
Authors: Freitas Thaís Campos de , Costa Ana Lúcia Barreto da , Sbardelotto Edriane Mara , Debortoli Elísio de Camargo , Hashimoto Juliano Hideo , Sada Jamile Cristina Deola , Gradin Joilson 
Published: February 2022

Na ovinocultura, uma das maiores perdas econômicas é a verminose, desta forma, o manejo integrado pode promover um bom desempenho na produção e consequentemente gerar menos perdas. Este trabalho teve por objetivo avaliar o perfil sanitário, por meio da associação entre a aplicação do método FAMACHA e a avaliação do Escore de Condição Corporal (ECC), de ovinos da raça Suffolk no IFRS – Campus Sertão. A amostra foi composta por 27 animais adultos totalizando 725 avaliações no ano de 2019. Foi observado que o método FAMACHA proporcionou redução nos gastos com vermífugos em 46,3% quando comparado ao manejo tradicional com duas vermifugações em todo o rebanho no período de análise. Como é um tratamento seletivo, associando as informações do ECC com o grau FAMACHA, apenas 3,72% dos animais foram vermifugados enquanto que os outros 96,28% possuíam carga parasitária baixa ou conseguiram suportar a carga parasitária sem apresentar sinais clínicos. Também foi possível classificar o rebanho em animais resistentes, resilientes e suscetíveis para a verminose. Tais resultados demonstram a importância do controle zootécnico e acompanhamento contínuo do rebanho, buscando proporcionar melhor desempenho produtivo e sanitário e consequentemente evitando o uso indiscriminado de antiparasitários e aprimorando a seleção de animais.
Susceptibility Modules and Genes in Hypertrophic Cardiomyopathy by WGCNA and ceRNA Network Analysis
Authors: Sun Yifan , Xiao Zhongbo , Chen Yequn , Xu Duanmin , Chen Shuying 
Published: February 2022

Background: We attempted to identify a regulatory competing endogenous RNA (ceRNA) network and a hub gene of Hypertrophic Cardiomyopathy (HCM).Methods: Microarray datasets of HCM tissue were obtained from NCBI Gene Expression Omnibus (GEO) database. The R package “limma” was used to identify differentially expressed genes. Online search databases were utilized to match the relation among differentially expressed long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and mRNAs. Weighted correlation network analysis (WGCNA) was used to identify the correlations between key modules and HCM. STRING database was applied to construct PPI networks. Gene Set Enrichment Analysis (GSEA) was used to perform functional annotations and verified the hub genes.Results: A total of 269 DE-lncRNAs, 63 DE-miRNAs and 879 DE-mRNAs were identified in myocardial tissues from microarray datasets GSE130036, GSE36946 and GSE36961, respectively. According to online databases, we found 1 upregulated miRNA hsa-miR-184 that was targeted by 2 downregulated lncRNAs (SNHG9, AC010980.2), potentially targeted 2 downregulated mRNAs (LRRC8A, SLC7A5). 3 downregulated miRNAs (hsa-miR-17-5p, hsa-miR-876-3p, hsa-miR-139-5p) that were targeted by 9 upregulated lncRNAs, potentially targeted 21 upregulated mRNAs. Black and blue modules significantly related to HCM were identified by WGCNA. Hub gene IGFBP5 regulated by hsa-miR-17-5p, AC007389.5, AC104667.1, and AC002511.2 was identified. GSEA indicated that IGFBP5 might involve in the synthesis of myosin complex, participate in kinesin binding, motor activity and function via the regulation of actin cytoskeleton.Conclusion: The results provide a potential molecular regulatory mechanism for the diagnosis and treatment of HCM. IGFBP5 might play an important role in the progression of HCM.
Effect of Graphite Oxide on the Catalytic Behavior of (S)-Selective Amine Transaminases
Authors: Kaloudis Nikolaos , Zygouri Panagiota , Chalmpes Nikolaos , Spyrou Konstantinos , Gournis Dimitrios , Pavlidis Ioannis V. 
Published: February 2022

Graphite oxide (GO) has been used for the immobilization of several classes of enzymes, exhibiting very interesting properties as an immobilization matrix. However, the effect the nanomaterial has on the enzyme cannot be predicted. Herein, the effect GO has on the catalytic behavior of several (S)-selective amine transaminases [(S)-ATAs] has been investigated. These enzymes were the focus of this work as they are homodimers with pyridoxal 5′-phosphate in their active site, significantly more complex systems than other enzymes previously studied. Addition of GO (up to 0.1 mg/ml) in the reaction medium leads to activation (up to 50% improved activity) for most enzymes studied, while they maintain their temperature profile (they perform better between 40 and 45°C) and their stability. However, the effect is not universal and there are enzymes that are negatively influenced by the presence of the nanomaterial. More profound is the effect on the (S)-ATA from Chromobacterium violaceum which loses almost 50% of its activity in the presence of 0.1 mg/ml GO, while the stability was significantly decreased, losing its activity after 2 h incubation at 40°C, in the presence of 25 μg/ml GO. This negative effect seems to rise from minor secondary structure alterations; namely, a loss of α-helices and subsequent increase in random coil (∼3% in the presence of 25 μg/ml GO). We hypothesize that the effect the GO has on (S)-ATAs is correlated to the surface chemistry of the enzymes; the less negatively-charged enzymes are deactivated from the interaction with GO. This insight will aid the rationalization of ATA immobilization onto carbon-based nanomaterials.
Using Leaf Ecological Stoichiometry to Direct the Management of Ligularia virgaurea on the Northeast Qinghai-Tibetan Plateau
Authors: Su Haohai , Cui Jiabao , Adamowski Jan F. , Zhang Xiaofang , Biswas Asim , Cao Jianjun 
Published: February 2022

Leaf ecological stoichiometry not only reflects the plasticity and adaptability, but also the growth of plants within environments where temperature, precipitation, and soil properties vary across an elevation gradient. Ligularia virgaurea (Maxim.) Mattf. ex Rehder &amp; Kobuski — an invasive poisonous plant — is common in the northeast portion of China’s Qinghai-Tibetan Plateau and its presence greatly affects the native ecosystem. Based on L. virgaurea leaf carbon ([C]leaf), nitrogen ([N]leaf) and phosphorus ([P]leaf) concentrations, and their ratios, the species’ coping strategies across an elevation gradient (2,600 m, 3,000 m, and 3,300 m) were identified, and served to inform the development of improved management strategies. Mean [C]leaf, [N]leaf and [P]leaf in L. virgaurea across all elevations were 413.14 g·kg−1, 22.76 g·kg−1, and 1.34 g·kg−1, respectively, while [C]leaf: [N]leaf, [C]leaf: [P]leaf, and [N]leaf: [P]leaf were 18.27, 328.76, and 17.93. With an increase in precipitation and decrease in temperature from 2,600 m to 3,000 m–3,300 m, [C]leaf, [C]leaf: [N]leaf and [C]leaf: [P]leaf of L. virgaurea decreased at first and then increased. The [N]leaf and [P]leaf gradually increased, whereas [N]leaf: [P]leaf showed little change. Although temperature, precipitation and soil water content were the main factors affecting the ecological stoichiometry of L. virgaurea leaves, their roles in influencing leaf elements were different. The [C]leaf was mainly influenced by soil water content, [N]leaf by temperature and soil water content, and [P]leaf by all of them. With potential future climate change in the study area, L. virgaurea may grow faster than at present, although soil P may still be a growth-limiting element. As L. virgaurea can reduce plant diversity and the quality of forage, while increasing biomass, management of L. virgaurea should receive greater attention.