bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation &amp; Testing of Emission on Sargassum wightii Based Flash Powder Composition
Authors: Gnanavel Jawahar Raj Sivanandha , Vignesh Nagarajan Jawahar 
Published: June 2022

Abstract
Environmental pollution is one of the major concerns leading to the rise in the temperature of the earth's surface. Owing to this serious concern, many countries in the world are facing so many environmental disasters every year. Hence, it becomes the need of the hour to act immediately to reduce environmental pollution so that the future becomes safer. Fireworks form an integral part of the Indian Subcontinent in almost all the festivals and cultural rituals. This results in the emission of a huge amount of various toxic fumes that directly affect the environmental purity of the air. The objective of the current research work focuses on the reduction of pollution caused due to the emission from burning fireworks. One of the important ingredients used in pyrotechnics is flash powder. The traditional flash powder composition contains aluminium powder as fuel, potassium nitrate as an oxidizer and Sulphur as an igniter at defined levels. To reduce the impact of toxic emissions in flash powder, an organic compound like Sargassum wightii brown seaweed powder is used as a replacement at prescribed levels and the experimentation is carried out. It is found that the Sulphur weightage in the flash powder composition can be replaced up to 50% with the Sargassum wightii brown seaweed powder without affecting the traditional performance of the flash powder. To study the emissions taking place in the flash powder composition, a specially designed flash powder emission testing chamber has been developed. Upon testing, it is evident that the flash powder composition with Sargassum wightii showed that there is a reduction in toxic emission upto 21% on the modified flash powder. This helps in generating cleaner emission and leads to attain greener pyrotechnics norms.
Development of a Classification Model for Physiological Parameters in Relation to Ecological Aspects Based on Cohort Data
Authors: Pimpale Yogita , Gupta Sachin 
Published: June 2022

Abstract
The ecological aspects such as environmental factors, socio economic constraints and demographic parameters are one of the key aspects to examine the health benefits of human subject and used as ready reference in eco system modelling. Presently, there are various kinds of deadly diseases and disorders who are liable for affecting the human health and impacting the eco framework of whole world. The virus such as Corona, Swine Flu, omicron and others are one of the best examples for the research community to understand the vulnerability of human health in relation to these unpredictable causes. As per report of world health organization every year more than ten million people are affected by such ecological and environmental disbalance. The impact of environmental factors on the functioning of several organs in humans appears to be significant. There is a need to understand this ecological model in relation to health of human subjects. In this study, a cohort-based data set of Ecological pollutants and Physiological signals such as ECG and anthropogenic data of human subjects were extracted from Maharashtra from 2015 to 2021. As per neural network-based hazard ratio was calculated and observed to be deplorable among unhealthy and health categories of human subjects. It has been concluded that the accumulative eco system is responsible for overburden to organs of living beings and policy makers must focus on the facts of study for modern management framework designs.
Spatial and temporal dynamics of air quality on the Red Sea – Application of satellite observations and back trajectory analysis
Authors: Mitra Bijoy , Hridoy Al-Ekram Elahee , Mahmud Khaled , Uddin Mohammed Sakib , Talha Abu , Das Nayan , Nath Sajib Kumar , Rahman Muhammad Muhitur , Rahman Syed Masiur 
Published: June 2022

Abstract
The Red Sea, lying between Asia and Africa, is a significant eco-region and the habitat of many marine species. It is an essential route for marine transportation, and it also provides many ecosystem services. Therefore, assessing the spatial and temporal distributions of air quality parameters over the Red Sea and assess temporal trends is important. This study investigated observations of multiple satellites to collect different meteorological and tropospheric columns of aerosols, trace gas including carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and ozone (O3), and meteorological data. The tropospheric columns of trace gases and aerosol index exhibit seasonal and regional characteristics over the Red Sea. The correlation coefficient for air pollutants (NO2, SO2, and O3) and meteorological parameters showed a positive medium and low correlation, whereas a negative correlation was found between O3, Aerosol Index (AI), and wind speed. The back trajectory transport of air mass component using Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model showed long-range trajectory pattern. AI, trace gases concentrations, and meteorological data were investigated through Principal Component Analysis (PCA) with varimax rotation to find a discerning relationship and co-variance between air pollutants and meteorological data. This showed a relationship between meteorological data and CO and O3. Although the satellite observations have some inherent limitations compared to in-situ measurements, this study provides an overall landscape of air pollution over the Red Sea, which will benefit policymakers and researchers.
Liquid Water on Cold Exo-Earths via Basal Melting of Ice Sheets
Authors: Ojha Lujendra , Troncone Bryce , Buffo Jacob , Journaux Baptiste , McDonald George 
Published: June 2022

Abstract
Liquid water is a critical component of habitability. However, the production and stability of surficial liquid water can be challenging on planets devoid of adequate greenhouse warming. On such cold, icy exo-Earths, basal melting of regional/global ice sheets by geothermal heat provides an alternative means of forming liquid water. Here, we model the thermophysical evolution of ice sheets to ascertain the geophysical conditions that allow liquid water to be produced and maintained at temperatures above freezing on exo-Earths. We show that even with modest, Moon-like geothermal heat, subglacial oceans of liquid water can form at the base of and within the ice sheets on exo-Earths. Furthermore, subglacial oceans may persist on exo-Earths for a prolonged period due to the billion-year half-lives of the heat-producing elements responsible for geothermal heat. These subglacial oceans, often in contact with the planet’s crust and shielded from the high energy radiation of their parent star by thick ice layers, may provide habitable conditions for an extended period.
Injectable decellularized cartilage matrix hydrogel encapsulating urine-derived stem cells for immunomodulatory and cartilage defect regeneration
Authors: Shen Bin , Zeng Junfeng , Huang Liping , Xiong Huazhang , Li Qianjin , Wu Chenyu , Huang Yizhou , Xie Huiqi 
Published: June 2022

Abstract
Reconstruction of complex cartilage defects has remained a great challenge for tissue engineering due to the lack of stem cells and chronic inflammation within the joint. In this study, we have developed an injectable pig cartilage-derived decellularized extracellular matrix (dECM) hydrogels for the repair of cartilage defects, which has shown sound biocompatibility and immunomodulatory capacity both in vitro and in vivo. The dECM hydrogels can enhance the chondrogenic differentiation of human urine-derived stem cells (USCs). As shown by in vitro experiment, the USCs in the dECM hydrogels have survived, proliferated, and produced a mass of cartilage-specific extracellular matrix containing collagen II and aggrecan. And the USCs-laden dECM hydrogels have shown the capacity to promote the secretion of extracellular matrix, modulate the immune response and promote cartilage regeneration in the rat model for cartilage defect.
A retrospective evaluation of short-term results from colonic stenting as a bridge to elective surgery versus emergency surgery for malignant intestinal obstruction
Authors: Chongjing Mu , Lei Chen 
Published: June 2022

Abstract
Purpose: The efficacy and safety of self-expanding metallic stent (SEMS) placement as a bridge to elective surgery versus emergency surgery to treat malignant intestinal obstruction is debated. This study aimed to evaluate the outcomes of patients with malignant intestinal obstruction treated using different procedure. Methods: Subjects admitted to the authors’ department with colonic obstruction (n = 87) were studied. They underwent colonic stenting as a bridge to elective surgery (SEMS group: n = 14) or emergency surgery (ES group:n=22).Their demographic characteristics, stoma rate, laparoscopy rate and postoperative complications were analyzed, and the potential risk factors of postoperative complications and the optimal time interval from SEMS implantation to elective surgery were explored. Results: The stoma rate was 15% in the SEMS group versus 60 % in the ES group (P = 0.02), and the postoperative complication rate was 8% in the SEMS group versus 40% in the ES group (P = 0.04). The proportion of patients undergoing laparoscopy in SEMS group was significantly higher than that in ES group (69% vs. 15%; P = 0.003).The effect of ASA grade on postoperative complications was statistically significant (OR = 24.6; P = 0.008). The Receiving operating characteristic(ROC) curve could not determine the optimal time interval between SEMS implantation and elective surgery (AUC = 0.466).Conclusions:SEMS implantation has the advantages of lower temporary stoma rate, less postoperative complications and higher laparoscopy rate compared with ES in the treatment of left malignant intestinal obstruction. ASA grade is a risk factor for postoperative complications. However, larger sample size prospective randomized controlled trials(RCT) are still needed to confirm long-term oncological outcomes.
Theory of optical axion electrodynamics and application to the Kerr effect in topological antiferromagnets
Authors: Ahn Junyeong , Vishwanath Ashvin , Xu Su-Yang 
Published: June 2022

Abstract
Electromagnetic fields in a magneto-electric medium behave in close analogy to photons coupled to the hypothetical elementary particle, the axion. This emergent axion electrodynamics is expected to provide novel ways to detect and control material properties with electromagnetic fields. Despite having been studied intensively for over a decade, its theoretical understanding remains mostly confined to the static limit. Formulating axion electrodynamics at general optical frequencies requires resolving the difficulty of calculating optical magneto-electric coupling in periodic systems and demands a proper generalization of the axion field. Here, we introduce a theory of optical axion electrodynamics. We define the proper optical axion magneto-electric coupling through its relation to optical surface Hall conductivity and provide ways to calculate it in quasi-two-dimensional and three-dimensional lattice systems. By employing our new formulae, we show that optical axion electrodynamics can lead to a significant Kerr effect but vanishing Faraday effect in fully compensated antiferromagnets, refuting the conventional wisdom that the Kerr effect is a measure of the net magnetic moment. Our work sets the foundation for a concrete understanding of the axion magneto-optic effects and opens up a promising route to studying antiferromagnetism with light. Our theory is particularly relevant to materials like MnBi$_2$Te$_4$, a topological antiferromagnet whose mageto electric response is shown here to be dominated by the axion contribution even at optical frequencies.
HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma
Authors: Garrett Matthew C. , Albano Rebecca , Carnwath Troy , Elahi Lubayna , Behrman Catherine , Pemberton Merissa , Woo Daniel , O’Brien Eric , VanCauwenbergh Brett , Perentesis John , Shah Sanjit , Hagan Matthew , Kendler Ady , Zhao Chuntao , Plas Dave , Paranjpe Aditi , Roskin Krishna , Kornblum Harley , Lu Richard 
Published: June 2022

Abstract
Introduction: Low-grade and secondary high-grade gliomas frequently contain a mutation in the IDH1 metabolic enzyme that is hypothesized to drive tumorigenesis by inhibiting many of the chromatin-regulating enzymes that regulate DNA structure. Much of the previous research has focused on DNA methylation leaving histone modifications relatively under-studied. Histone deacetylase inhibitors are promising anti-cancer agents and have already been used in clinical trials, however a clear understanding of their mechanism or gene targets is lacking. In this study, the authors genetically dissect patient-derived IDH1 mutant cultures to determine which HDAC enzymes drive growth in IDH1 mutant gliomas and what are the down-stream gene targets. This information will allow clinicians to design more specific HDAC inhibitors as well as monitor for treatment response. Methods: A panel of patient-derived gliomasphere cell lines (2 IDH1 mutant lines, 3 IDH1 wildtype lines) were subjected to a drug-screen of 110 epigenetic modifying drugs from 34 different epigenetic classes. The effect of LBH (Panobinostat) on gene expression and chromatin structure was tested on patient-derived IDH1 mutant lines. The role of each of the highly expressed HDAC enzymes was molecularly dissected using lentiviral RNA interference knock-down vectors and a patient-derived IDH1 mutant in vitro model of glioblastoma (HK252). These results were then confirmed in an in vivo xenotransplant model (BT-142). Results: The IDH1 mutation leads to gene down-regulation, DNA hypermethylation, increased DNA accessibility and H3K27 hypo-acetylation in two distinct IDH1 mutant over-expression models. The drug screen identified histone deacetylase inhibitors (HDACi) and Panobinostat (LBH) more specifically as the most selective compounds to inhibit growth in IDH1 mutant glioma lines. Of the eleven annotated HDAC enzymes (HDAC1-11) only six are expressed in IDH1 mutant glioma tissue samples and patient-derived gliomasphere lines (HDAC1, HDAC2, HDAC3, HDAC4, HDAC6, HDAC9). Lentiviral knock-down experiments revealed that HDAC1 and HDAC6 are the most consistently essential for growth both in vitro and in vivo and target very different gene modules. Knock-down of HDAC1 or HDAC6 in vivo led to a more circumscribed less invasive tumor. Conclusions: The gene dysregulation induced by the IDH1 mutation is wide-spread and only partially reversible by direct IDH1 inhibition. This study reports a previously under-described phenomenon of histone deacetylation induced by the IDH1 mutant enzyme and identifies HDAC1 and HDAC6 as important and drug-targetable enzymes that are necessary for growth and invasiveness in IDH1 mutant gliomas.
Unusual cause of Long QT in a young man
Authors: Mazzanti Camilla , Ferrari Valeria , Galastri Silvia , Martelletti Paolo , De Biase Luciano 
Published: June 2022

Abstract
Several conditions may be responsible for long QT syndrome, among which electrolyte disturbances play a major role, particularly hypopotassemia and hypomagnesemia. Although the causes can be countless, it is good practice to always perform an accurate anamnesis, a thorough physical examination and targeted laboratory tests. Gitelman Syndrome is one of the rare disorders that could manifest with these electrolyte alterations. It is a hereditary tubulopathy which impairs the kidney’s ability to reabsorb salt resulting in hypokalemia, hypomagnesemia, metabolic alkalosis and increased urinary potassium excretion. We report the case of an 18-year-old boy, almost asymptomatic, with a persistent prolongation of QT interval diagnosed by ECG during a sport medical examination. Genetic analysis did not identify any gene related to known Long QT syndromes. To complete the diagnostic process a dynamic ECG and a stress test were also carried out to evaluate any ventricular arrhythmia, a possible fatal consequence of QT prolongation. Echocardiogram did not show any structural abnormality. Laboratory tests performed fit all the criteria for Gitelman syndrome. Amiloride and a specific diet with magnesium and potassium integration were prescribed and resulted in a shortening of the QT interval, a normalization of the kaliemia and a reduction of the asthenia.
QTL mapping for bacterial leaf blight resistance in RIL’s derived from Danteshwari x Dagad Deshi
Authors: Kumar Indra , KOSHARIYA ASHOK , Baral Deewakar , Kotasthane Anil S 
Published: June 2022

Abstract
In ”present study, quantitative trait loci (QTL) analysis was carried out using SSR HvSSR markers in F7 recombinant inbred lines derived from a cross between two potential indica genotypes, Danteshwari and Dagad Deshi”. A recombinant inbred line (RIL) population consisting of 122 lines was constructed from a cross between Danteshwari a high yielding popular rice cultivar and Dagad Deshi a tall deep rooted poor yielder”. “Six QTL’s were identified on chromosome1, 5, & 9 for bacterial blight tolerance” and explained 0.17% - 8.24% phenotypic variation at LOD value of > 2.5. “Three QTL’s were on CH# 1 (marker interval RM259 to RM243, RM572 to 58.61 cM and RM3825 to 147.21 cM), one on CH#5 (marker interval RM188 to 101.01cM) and two on CH#9 (marker interval HvSSR937 to 67.61 cM, and RM242 to RM278) which influenced lesion length”. “QTL influencing lesion length with positive additive effect” (one) “and negative additive effects” (05) were “identified indicating” that “alleles at these loci are being contributed by either of the parents respectively”.
Accuracy of an image-free handheld hip navigation device for total hip arthroplasty in a lateral decubitus position
Authors: Naito Yohei , Hasegawa Masahiro , Tone Shine , Wakabayashi Hiroki , Sudo Akihiro 
Published: June 2022

Abstract
Background: Portable navigation systems have been developed for use in total hip arthroplasty (THA) in recent years. The purpose of this study was to investigate the accuracy of cup insertion in primary THA using an image-free handheld navigation device in the lateral decubitus position.Methods: This retrospective study included 68 consecutive cementless THAs performed using an image-free handheld navigation device and 68 consecutive THAs performed without a navigation system as historical controls. All cases underwent THAs in a lateral decubitus position. Postoperative cup radiographic inclination and radiographic anteversion were assessed, and the accuracy of cup insertion was compared between the two groups. Navigation error was also assessed.Results: The mean absolute errors of the postoperative measured inclination from the target inclination were 3.9° ± 2.2° in the navigation group and 8.5° ± 6.9° in the control group (p<0.001). The mean absolute errors of anteversion were 4.8° ± 3.5° in the navigation group and 11.4° ± 6.6° in the control group (p<0.001). The percentage of cups inside Lewinnek’s safe zone was 94% in the navigation group and 37% in the control group (p<0.001). The mean absolute values of navigation error were 3.1° ± 2.1° in inclination and 4.2° ± 2.8° in anteversion. No factors affected the navigation errors.Conclusions: Use of an image-free handheld navigation device can improve the accuracy of cup insertion compared with conventional manual technique in THA in the lateral decubitus position.
The Stock Correlation Network Model and Its Influencing Factors in China's Green Finance Market
Authors: Ma Qianting , Zhao Jiaxin , Ji Xiaoyang , Shi Junchi , Chen Xi 
Published: June 2022

Abstract
Green finance is a significant step to achieving environmentally sustainable development in the context of carbon neutrality. Based on the perspective of the stock correlation network, we select 51 green and environmental protection enterprises and construct the stock correlation network model in China's green financial market according to the correlation of their stock price fluctuations. On this basis, it discusses its network topologies and its dynamic evolution characteristics. After that, it deeply studies its impact mechanism of systemically importance in China's green financial market and introduces the major green financial policies for comparative analysis. In the light of empirical research, we can obtain the following results. First, the stock size distribution in China's green financial market has a power-law tail. Second, a sharp drop in the market index will increase the aggregation of the stock correlation network in the green financial market. Third, the variables about corporate social responsibility, corporate R&D investment intensity, and corporate green innovation output play significant roles in promoting the individual companies’ systemically importance ranking in the stock correlation networks of China’s green financial market. Fourth, the implementation of major green financial policies has promoted the improvement of the systematic importance of state-owned enterprises. Finally, the research enriches the application research of complex network theory in the green financial market and provides practical guidance for regulators to strengthen the risk monitoring of the green financial market.
Polyamide membrane pretreatment combined with UPLC–MS/MS for the determination of industrial dyes in grain and meat products
Authors: He Yahui , Liu Xinyu , Zhu Yao , Liu Yajie , Li Lu , Wang Jing , El-Aty A. M. Abd 
Published: June 2022

Abstract
Herein, ultra-performance liquid chromatography-tandem four-stage mass spectrometry (UPLC–MS/MS) combined with a novel polyamide membrane extraction was used to rapidly determine industrial dyes in grain and meat products. Polyamide was used as an adsorbent in the membrane. When the sample was treated by the polyamide membrane, the industrial dyes were absorbed by the N-propyl Ethylenediamine (PSA) into the polyamide membrane, while most other ingredients were passed through the membrane. Then, the industrial dyes were eluted from the polyamide membrane by different solvents to be analyzed by UPLC–MS/MS. The novel pretreat method will reduce the time of the whole process to less than 30 minutes. The recovery of the dye was between 71% and 126%, and the precision was between 3 and 13. The results showed that the polyamide membrane can be used as a pretreatment method for detecting multicomponent industrial dyes in grain and meat products, which is rapid, simple, reliable and accurate.
A Novel Hybrid Intelligence Framework using Harmony Search and Quick ABC (HS-qABC) for OCL Constraint Based Testing
Authors: Dharmalingam Jeya Mala , Abraham Pradeep Reynold 
Published: June 2022

Abstract
Exploring testing possibilities at an early software life cycle is becoming increasingly necessary to improve the reliability of a system. It facilitates the removal of most of the errors at the earliest, thereby avoiding propagation of defects to the subsequent phases. Constraint-Based Testing (CBT) is a prominent form of functional testing approach that can be performed at the earliest. The efficiency of CBT can be improved by combining it with the Search Based Testing (SBT) technique, in which case SBT can be used to produce test suites while the constraints can be used to guide the test case generation process. Hence, the proposed work combines OCL (Object Constraint Language) and hybrid Harmony Search – Quick Artificial Bee Colony (HS-qABC) algorithm to generate efficient test cases. Furthermore, a novel predicate-based fitness function named as exit-predicate-wise branch coverage (EPWBC) is defined to evaluate the generated test data. The experimental results indicate that OCL constraint-based testing adopting hybrid HS-qABC algorithm forms an excellent combination to produce more test coverage and optimal test suite. Furthermore, it has been inferred that hybrid HS-qABC algorithm outperforms the other search approaches in test suite optimization.