bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative review of non‐pharmacological intervention and multidimensional evaluation for intraoperative anxiety under spinal anaesthesia
Authors: Lim Kyuhee , Jung Sooah , Kim Heejung 
Published: March 2022

AbstractIntroductionPatients under spinal anaesthesia experience high levels of anxiety during surgery. Clinical nurses tried to manage patient's anxiety under spinal anaesthesia using non‐pharmacological interventions for its benefit. Thus, it is required to identify comprehensive evidences of various non‐pharmacological interventions and of how to measure anxiety under spinal anaesthesia.AimsThis study aims to review current research on the non‐pharmacological interventions to relieve intraoperative anxiety under spinal anaesthesia and to identify subjective and objective measures of intraoperative anxiety under spinal anaesthesia.MethodsWittemore and Knafl's integrative review methodology was used. Researchers conducted five scientific rigor steps; problem identification, searching literature, evaluation of literature, analysis of literature and presentation of results. The PRISMA checklist was used. To evaluate the level of evidence, critical appraisal tools of Joanna Briggs Institute were used.ResultsEleven studies were included in this integrative review. Delivering music is the most frequently used as non‐pharmacological intervention by researchers. They tried to manage intraoperative anxiety under spinal anaesthesia with using diverse genre and application of music. In addition, dry cupping method, progressive muscle relaxation (PMR) exercise and virtual reality (VR) goggles were used in included studies. Researchers measured intraoperative anxiety under spinal anaesthesia with objective or subjective way. The State‐Trait Anxiety Inventory and visual analogue scale were used as subjective method to approach intraoperative anxiety. In contrary, researchers tried to obtain objective evidence of intraoperative anxiety with vital signs, cortisol, blood glucose, alpha‐amylase and adrenocorticotropic hormone.ConclusionVarious types of non‐pharmacological interventions are effective to manage patient's intraoperative anxiety under spinal anaesthesia. It is recommended to measure intraoperative anxiety under spinal anaesthesia with using both objective and subjective methods.Relevance to Clinical PracticeClinical nurses can use non‐pharmacological interventions to manage intraoperative anxiety under spinal anaesthesia by comprehensive monitoring with diverse measures.
LSD3 mediates the oxidative stress response through fine‐tuning APX2 activity and the NF‐YC15‐GSTs module in cassava
Authors: Zeng Hongqiu , Xu Haoran , Wang Hao , Chen Hao , Wang Guanqi , Bai Yujing , Wei Yunxie , Shi Haitao 
Published: March 2022

SUMMARYReactive oxygen species (ROS) overproduction leads to oxidative damage under almost all stress conditions. Lesion‐Simulating Disease (LSD), a zinc finger protein, is an important negative regulator of ROS accumulation and cell death in plants. However, the in vivo role of LSD in cassava (Manihot esculenta) and the underlying molecular mechanisms remain elusive. Here, we found that MeLSD3 is essential for the oxidative stress response in cassava. MeLSD3 physically interacted with ascorbate peroxidase 2 (MeAPX2), thereby promoting its enzymatic activity. In addition, MeLSD3 also interacted with the nuclear factor YC15 (MeNF‐YC15), which also interacted with nuclear factor YA2/4 (MeNF‐YA2/4) and nuclear factor YB18 (MeNF‐YB18) to form an MeNF‐YC15–MeNF‐YA2/4–MeNF‐YB18 complex. Notably, MeLSD3 positively modulated the transcriptional activation of the MeNF‐YC15–MeNF‐YA2/4–MeNF‐YB18 complex by interacting with the CCAAT boxes of the promoters of glutathione S‐transferases U37/U39 (MeGST‐U37/U39), activating their transcription. When one or both of MeLSD3 and the MeNF‐YC15–MeNF‐YA2/4–MeNF‐YB18 complex were co‐silenced, cassava showed decreased oxidative stress resistance, while overexpression of MeGST‐U37/U39 alleviated the oxidative stress‐sensitive phenotype of these silenced plants. This study illustrates the dual roles of MeLSD3 in promoting MeAPX2 activity and MeNF‐YC15–MeGST‐U37/U39 regulation, which underlie the oxidative stress response in cassava.
Reviewer Acknowledgements
Authors: Smith Robert 
Published: March 2022

Journal of Education and Training Studies (JETS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether JETS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 10, Number 2 John Cowan, Edinburgh Napier University, UKKeyla Ferrari Lopes, UNICAMP, BrazilMichail Kalogiannakis, University of Crete, GreeceMuhammad Haris Effendi-Hasibuan, Universitas Jambi, IndonesiaNiveen M. Zayed, MENA College of Management, JordanRichard H. Martin, Mercer University, USARichard Penny, University of Washington Bothell, USASandro Sehic, Oneida BOCES, USASarah Nabih Nasif, October University, EgyptSenem Seda Şahenk Erkan, Marmara University, Turkey Robert SmithEditorial AssistantOn behalf of,The Editorial Board of Journal of Education and Training StudiesRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAE-mail 1: jets@redfame.comE-mail 2: jets@redfame.orgURL: http://jets.redfame.com
Consumo estatutario y desigualdad económica
Authors: Velandia-Morales Andrea , Rodríguez-Bailón Rosa , Martínez Rocío 
Published: March 2022

La desigualdad económica provoca múltiples consecuencias psicosociales. El objetivo principal de este trabajo es identificar la relación entre la desigualdad económica objetiva (GINI) y percibida (PDE) con el consumo estatutario, el materialismo y el endeudamiento. Además, se analiza la búsqueda de estatus como posible mediador entre la desigualdad (objetiva/percibida) y el consumo estatutario, así como se explora el rol de la percepción de justicia en la distribución de recursos en esta relación. Se utiliza un diseño ex-post-facto retrospectivo de medidas múltiples. Los datos se recogieron mediante un cuestionario autoadministrado en dos contextos diferentes: Colombia (N= 217) y España (N=119). Los resultados mostraron que la relación entre la desigualdad objetiva y la preferencia por productos estatutarios, está mediada por la búsqueda de estatus (B = 0.10, SE = 0.03, 95 % IC = [0.0441, 0.1683]) y moderada por la percepción de justicia en la distribución de recursos (B = -0.25, SE = 0.10, t(322) = -2.49, p < 0.005). Estos resultados muestran cómo las preferencias de consumo están influenciadas no solo por variables psicológicas, sino también por variables ideológicas y económicas de carácter estructural, siendo importante manipular la desigualdad económica en diferentes escenarios para analizar si los resultados se mantienen a nivel causal.
Metagenomics: A New Direction in Ecology
Authors: Vecherskii M. V. , Semenov M. V. , Lisenkova A. A. , Stepankov A. A. 
Published: March 2022

Abstract
The prospects for application of metagenomic technologies in environmental studies are discussed. The advantages in investigating the taxonomic composition of aquatic and terrestrial ecosystems, as well as examples of trophic and phoric relationships found in ecosystems using the metagenomic approach, are described. The capabilities of metagenomics to study prokaryotic communities in complicated environments such as soils or animal intestines are shown. The role of relic DNA in the metagenome and the possibilities to study ancient organisms are highlighted. Particular attention is paid to the criticism of metagenomic technologies related to the low reproducibility of the sequencing data. Common methodological mistakes in bioinformatics processing of metagenomic data leading to misleading results are considered.
National experience in the first two years of primary human papillomavirus (HPV) cervical screening in an HPV vaccinated population in Australia: observational study
Authors: Smith Megan A , Sherrah Maddison , Sultana Farhana , Castle Philip E , Arbyn Marc , Gertig Dorota , Caruana Michael , Wrede C David , Saville Marion , Canfell Karen 
Published: March 2022

AbstractObjectiveTo review the first two years of the primary human papillomavirus (HPV) cervical screening programme in an HPV vaccinated population.DesignObservational study.SettingAustralia.Participants3 745 318 women with a primary HPV test between 1 December 2017 and 31 December 2019; most women aged <40 years had previously been offered vaccination against HPV16 and HPV18.InterventionsPrimary HPV screening with referral if HPV16 or HPV18 (HPV16/18) positive and triage with liquid based cytology testing (threshold atypical squamous cells-cannot exclude high grade squamous intraepithelial lesion) for women who were positive for high risk HPV types other than 16/18. A 12 month follow-up HPV test was recommended in triaged women with a negative or low grade cytology result, with referral if they tested positive for any high risk HPV type at follow-up.Main outcome measuresProportion of women who had attended for their first HPV screening test, tested positive, and were referred for colposcopy; and short term risk of detecting cervical intraepithelial neoplasia (CIN) grade 2 or worse, CIN grade 3 or worse, or cancer.Results54.6% (n=3 507 281) of an estimated 6 428 677 eligible women aged 25-69 had undergone their first HPV test by the end of 2019. Among those attending for routine screening, positivity for HPV16/18 and for HPV types not 16/18 was, respectively, 2.0% and 6.6% in women aged 25-69 (n=3 045 844) and 2.2% and 13.3% in highly vaccinated cohorts of women aged 25-34 (n=768 362). Colposcopy referral (ages 25-69 years) was 3.5%, increasing to an estimated 6.2% after accounting for women who had not yet had a 12 month repeat test. Cervical cancer was detected in 0.98% (456/46 330) of women positive for HPV16/18 at baseline, including 0.32% (89/28 003) of women with HPV16/18 and negative cytology. Women with HPV types not 16/18 and negative or low grade cytology at both baseline and 12 months were at low risk of serious disease (3.4% CIN grade 3 or worse; 0.02% cancer; n=20 019) but estimated to account for 62.0% of referrals for this screening algorithm.ConclusionsColposcopy referral thresholds need to consider underlying cancer risk; on this basis, women with HPV16/18 in the first round of HPV screening were found to be at higher risk regardless of cytology result, even in a previously well screened population. Women with HPV types not 16/18 and negative or low grade cytology showed a low risk of serious abnormalities but constitute most referrals and could be managed safely with two rounds of repeat HPV testing rather than one. HPV16/18 driven referrals were low in HPV vaccinated cohorts.
Post-traumatic stress disorder in patients with rheumatic disease during the COVID-19 outbreak: a cross-sectional case–control study in China
Authors: Wu Xin , Geng Xuqiang , Shang Zhilei , Wang Zhen , Lu Hongjuan , Ma Haiying , Liu Weizhi , Xu Huji 
Published: March 2022

ObjectiveThe COVID-19 pandemic is not only a traumatic event, but a collective stressor unfolding over time, causing devastating implications for the mental health. This study aimed to shed light on the mental health status of patients with rheumatic disease (RD) during the massive outbreak of COVID-19 in China, especially the prevalence and severity of post-traumatic stress disorder (PTSD) compared with healthy individuals.MethodsA total of 486 patients with RD and 486 age-matched and sex-matched healthy individuals were recruited into the study. For each participant, we collected demographic and clinical characteristics data. The PTSD Checklist for DSM-5 (PCL-5) and four items from the Pittsburgh Sleep Quality Index (PSQI) were used to investigate the prevalence and severity of PTSD and sleep quality, respectively.ResultsCompared with healthy control subjects (n=486), patients with RD (n=486) had a higher prevalence of PTSD (12.1% vs 4.1%; p<0.001). Higher total scores on the PCL-5 and on all four items from the PSQI (p≤0.001) were also observed. Female, old age, poor sleep quality, long duration of RD, poor subjective evaluation of the disease and pessimistic subjective perception of the epidemic were identified as risk factors of PTSD in patients with RD during the COVID-19 epidemic.ConclusionDuring the COVID-19 outbreak, patients with RD presented a higher prevalence and severity of PTSD and showed more sleep disturbances. Our findings confirm the importance of psychological assessment and mental healthcare out of regular clinical care for patients with RD during the pandemic.
Nervous system drugs taken by future fathers and birth defects in offspring: a prospective registry-based cohort study
Authors: Wensink Maarten , Lu Ying , Tian Lu , Jensen Tina Kold , Skakkebæk Niels Erik , Lindahl-Jacobsen Rune , Eisenberg Michael 
Published: March 2022

ObjectivesTo evaluate the association of paternal intake of antipsychotics, anxiolytics, hypnotics and sedatives, antidepressants, selective serotonin reuptake inhibitors (SSRIs) and (benzo)diazepines during the development of fertilising sperm with birth defects in offspring.DesignProspective registry-based cohort study.SettingTotal Danish birth cohort 1997–2016 using Danish national registries.ParticipantsAll 1 201 119 Danish liveborn singletons born 1997–2016 were eligible, 39 803 (3.3%) of whom had at least one major birth defect.ExposureOffspring were considered exposed if their father had filled at least one prescription in the relevant drug category during development of fertilising sperm (the 3 months prior to conception).Primary and secondary outcome measuresPrimary outcome was the diagnosis, in the first year of life, of at least one major birth defect as categorised in the EUROCAT guidelines. Secondary outcome was the diagnosis, in the first year of life, of at least one major birth defect in any of the EUROCAT subcategories. Adjusted ORs (AORs) were calculated, along with their 95% CIs, adjusted for year, education, smoking status and age of the mother, and education, disposable income and age of the father.ResultsThis study found weak or null associations between birth defects and selected drugs. Specifically, antidepressants (17 827 exposed births) gave 3.5% birth defects (AOR 0.97 (0.89 to 1.05)). Diazepines, oxazepines, thiazepines and oxepines (as antipsychotics, 1633 offspring) gave 4.7% birth defects (AOR 1.22 (0.97 to 1.54)), attenuated to 1.13 when excluding by mothers’ prescriptions. The study was well powered assuming 100% therapy adherence, while assuming 50% therapy adherence, the study remained well powered for the largest groups (SSRIs and antidepressants overall).ConclusionsAntipsychotics, anxiolytics, hypnotics and sedatives, antidepressants, SSRIs and benzodiazepine-derived anxiolytics, when taken by the father during development of fertilising sperm, are generally safe with regard to birth defects.
Trends in the shape of the income–mortality association in Sweden between 1995 and 2017: a repeated cross-sectional population register study
Authors: Rehnberg Johan , Östergren Olof , Fors Stefan , Fritzell Johan 
Published: March 2022

ObjectiveWe investigate recent trends in income inequalities in mortality and the shape of the association in Sweden. We consider all-cause, preventable and non-preventable mortality for three age groups (30–64, 65–79 and 80+ years).Design and settingRepeated cross-sectional design using Swedish total population register data.ParticipantsAll persons aged 30 years and older living in Sweden 1995–1996, 2005–2006 and 2016–2017 (n=8 084 620).MethodsRate differences and rate ratios for all-cause, preventable and non-preventable mortality were calculated per income decile and age group.ResultsFrom 1995 to 2017, relative inequalities in mortality by income increased in Sweden in the age groups 30–64 years and 65–79 years. Absolute inequalities increased in the age group 65–79 years. Among persons aged 80+ years, inequalities were small. The shape of the income–mortality association was curvilinear in the age group 30–64 years; the gradient was stronger below the fourth percentile. In the age group 65–79 years, the shape shifted from linear in 1995–1996 to a more curvilinear shape in 2016–2017. In the oldest age group (80+ years), varied shapes were observed. Inequalities were more pronounced in preventable mortality compared with non-preventable mortality. Income inequalities in preventable and non-preventable mortality increased at similar rates between 1995 and 2017.ConclusionsThe continued increase of relative (ages 30–79 years) and absolute (ages 65–79 years) mortality inequalities in Sweden should be a primary concern for public health policy. The uniform increase of inequalities in preventable and non-preventable mortality suggests that a more complex explanatory model than only social causation is responsible for increased health inequalities.
Did an introduction of CONSORT for abstracts guidelines improve reporting quality of randomised controlled trials’ abstracts onHelicobacter pyloriinfection? Observational study
Authors: Vrebalov Cindro Pavle , Bukic Josipa , Pranić Shelly , Leskur Dario , Rušić Doris , Šešelja Perišin Ana , Božić Joško , Vuković Jonatan , Modun Darko 
Published: March 2022

ObjectiveTo determine abstracts’ adherence to the Consolidated Standards of Reporting Trials for Abstracts (CONSORT-A) statement and to explore the factors associated with reporting quality.DesignAn observational study.SettingAbstracts of randomised controlled trials published between 2010 and 2019, found searching the MEDLINE database.ParticipantsA total of 451 abstracts of the clinical trialson Helicobacter pyloriinfections were included.Primary and secondary outcome measuresAbstracts’ reporting quality was determined by assessing their adherence to 17-item CONSORT-A checklist, with overall score being calculated as the sum of items that were adequately reported for each abstract. Additional factors that might influence the reporting quality of the abstracts were analysed, with univariate and multivariate linear regression used to determine how those factors influenced the overall reporting quality.ResultsIncluded abstracts had an overall median quality score of 8/17 (IQR 7–9). Large proportions of abstracts adequately reported interventions, participants, objectives, numbers randomised and conclusions (97.1, 99.3, 89.1. 94.7 and 98.4% of abstracts, respectively). Trial design, randomisation, blinding and funding were severely under-reported with only 8.0, 2.7, 11.0 and 2.0% of abstracts reporting each item. Overall quality scores forH. pyloriabstracts were higher in association with CONSORT-A endorsement (B=5.698; 95% CI 1.781 to 9.615), pharmacological interventions (B=4.063; 95% CI 0.224 to 7.902), multicentre settings (B=5.057; 95% CI 2.370 to 7.743), higher numbers of participants (B=3.607; 95% CI 1.272 to 5.942), hospital settings (B=4.827; 95% CI 1.753 to 7.901) and longer abstracts (B=3.878; 95% CI 0.787 to 6.969 for abstracts with 251–300 words and B=7.404; 95% CI 3.930 to 10.878 for abstracts with more than 300 words).ConclusionsThe overall reporting quality of abstracts was inadequate. The endorsement of CONSORT-A guidelines by more journals might improve the standards of reporting.
Use and diagnostic value of liver enzyme tests in the emergency department and subsequent heart failure diagnosis: a retrospective cohort study
Authors: Vasti Elena , Tabas Jeffrey A , Hoffman Ari , Pletcher Mark 
Published: March 2022

ObjectivesTo determine (1) if liver function tests (LFTs) are ordered in the emergency department (ED) in patients with suspected acute decompensated heart failure (ADHF) and (2) if the pattern of LFT abnormalities are meaningfully associated with a discharge diagnosis of ADHF among patients for whom these tests were ordered.SettingWe conducted a single-centre retrospective cohort study of patients with suspected ADHF who were seen in an academic tertiary ED using electronic medical records.ParticipantsAll ED patients admitted with suspected ADHF from January 2017 to May 2018, defined as any patient who had a brain natriuretic peptide (BNP) ordered.Primary outcomeThe primary outcome was ADHF diagnosis at discharge.ResultsIn 5323 ED patients with suspected ADHF, 60% (n=3184) had LFTs ordered; 34.6% were abnormal. Men comprised 56% of patients with abnormal LFTs and the average age was 67 years. The odds of a final diagnosis of ADHF in the univariate analysis was 59% higher in patients with abnormal LFTs (OR=1.59, (95% CI 1.35 to 1.87) p<0.001) and remained significant though attenuated after adjusting for BNP, race and ethnicity and age (ORadj=1.31 (95% CI 1.09 to 1.57), p=0.004). Likelihood ratios for abnormal and normal LFTs were 1.2 (95% CI 1.21 to 1.28) and 0.76 (95% CI 0.68 to 0.84), respectively.ConclusionsA significant proportion (40%) of patients with suspected ADHF was missing LFTs in their ED workup. Among patients with LFTs, abnormal LFTs are associated with discharge diagnosis of ADHF after accounting for potential confounders, but their diagnostic value was relatively low. Future prospective studies are warranted to explore the role of LFTs in the workup of ADHF.
Applicability of predictive models for 30-day unplanned hospital readmission risk in paediatrics: a systematic review
Authors: Niehaus Ines Marina , Kansy Nina , Stock Stephanie , Dötsch Jörg , Müller Dirk 
Published: March 2022

ObjectivesTo summarise multivariable predictive models for 30-day unplanned hospital readmissions (UHRs) in paediatrics, describe their performance and completeness in reporting, and determine their potential for application in practice.DesignSystematic review.Data sourceCINAHL, Embase and PubMed up to 7 October 2021.Eligibility criteriaEnglish or German language studies aiming to develop or validate a multivariable predictive model for 30-day paediatric UHRs related to all-cause, surgical conditions or general medical conditions were included.Data extraction and synthesisStudy characteristics, risk factors significant for predicting readmissions and information about performance measures (eg, c-statistic) were extracted. Reporting quality was addressed by the ‘Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis’ (TRIPOD) adherence form. The study quality was assessed by applying six domains of potential biases. Due to expected heterogeneity among the studies, the data were qualitatively synthesised.ResultsBased on 28 studies, 37 predictive models were identified, which could potentially be used for determining individual 30-day UHR risk in paediatrics. The number of study participants ranged from 190 children to 1.4 million encounters. The two most common significant risk factors were comorbidity and (postoperative) length of stay. 23 models showed a c-statistic above 0.7 and are primarily applicable at discharge. The median TRIPOD adherence of the models was 59% (P25–P75, 55%–69%), ranging from a minimum of 33% to a maximum of 81%. Overall, the quality of many studies was moderate to low in all six domains.ConclusionPredictive models may be useful in identifying paediatric patients at increased risk of readmission. To support the application of predictive models, more attention should be placed on completeness in reporting, particularly for those items that may be relevant for implementation in practice.