bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urgensi Pendidikan Literasi Media Digital untuk Meningkatkan Tingkat Kecakapan Digital
Authors: Yulista Yera 
Published: April 2022

Pada saat ini kita sudah memasuki era dunia maya, era yang hidup bersandingan dengan dunia nyata. Dunia maya yang didalamnya terdapat sejumlah aktivitas manusia yang saling keterhubungan satu sama lain dalam rangka mencapai tujuan masing-masing dari setiap pengguna, interaksi dalam dunia maya yang aktivitas selanjutnya masih dapat dilanjutkan dalam dunia nyata. Hal ini jelas menunjukkan adanya kemajuan teknologi sehingga memudahkan akses untuk saling berkomunikasi dan berbagi informasi, kemajuan teknologi ini jelas akan berdampak pada semakin dipermudahnya aktivitas manusia baik untuk urusan pribadi maupun urusan organisasi sehingga pekerjaan jauh lebih efektif dan efisien didapatkan. Namun sayangnya dibalik kemudahan tersebut kemajuan teknologi dari internet ini juga dimanfaatkan untuk melakukan tindakan yang merugikan orang lain baik dalam penyebaran informasi yang mengandung unsur kebohongan, aksi untuk menjatuhkan orang lain, pornografi,kecurangan, sarana konflik , kriminalitas serta beragam macam aksi tidak terpuji lainnya. Hal ini tentunya sangatlah meresahkan masyarakat, jika solusi masalah ini kurang ditanggapi dengan serius maka akan dikhawatirkan hal yang sama akan terus terulang. Oleh sebab itu sangat diperlukan dukungan dari semua pihak untuk solusi menghadapi penyalahgunaan media internet ini agar masyarakat dapat merasa damai menjadi bagian dari masyarakat maya.
Kementrian Komunikasi dan Informatika dalam rangka memahami masalah tersebut bekerjasama dengan Jaringan Pegiat Literasi Digital (Japelidi) dan Siberkreasi menyusun empat modul yang akan menjadi sebuah program untuk meningkatkan pengetahuan masyarakat dalam menggunakan media digital sehingga akan meningkatkan tingkat kecakapan/kepintaran dalam mengakses internet .
Problematika Pembelajaran Daring
Authors: Lestari Heldia Oldia , Pratama Dinar 
Published: April 2022

Pandemi covid-19 yang berdampak pada bidang pendidikan telah merubah proses pembelajaran dari tatap muka ke pembelajaran daring. Terdapat beberapa hal penting untuk dicermati dalam pembelajaran daring yaitu: pertama, untuk memahami bagaimana orang tua siswa di Kecamatan Namang menyikapi pembelajaran daring, kedua, mengetahui pendapat siswa mengenai pembelajaran daring, ketiga, memahami keterbatasan pengetahuan dan fasilitas internet sebagai kendala dalam pembelajaran daring. Penelitian Ini merupakan penelitian kualitatif dengan pendekatan fenomenologi. Hasil penelitian menunjukkan bahwa: (1) Orang tua yang memiliki anak usia SD, SMP, dan SMA, di Kecamatan Namang setuju dengan kebijakan pembelajaran daring (2) Siswa SD, SMP, dan SMA di Kecamatan Namang menganggap kurang efektif pembelajaran daring. (3) Keterbatasan pengetahuan dan fasilitas internet menjadi kendala utama dalam pembelajaran daring. Penelitian lanjutan dapat dilakukan untuk memahami kendala dan tingkat pengetahuan orang tua dan siswa dalam menggali informasi dari informan.
Perspective on the Relationship between Banking Education and English Achievement. A Case of Fresh EFL Students at King Khalid University
Authors: Elnadeef Elsadig Ali Elsadig 
Published: April 2022

This study investigates the impact of banking education centeredness on fresh students’ English language performance at King Khalid University. Banking education is evolved by Paul Ferriere proposing narration of the teacher subject (active participant) whereas the student is the passive object and teacher. It aims at highlighting the impact of banking education and English teacher centeredness on students’ achievement in productive and critical skills. The study is based on action research entailing fresh 50 male fresh students studying an English intensive course at King Khalid University, College of Sciences and Arts –Dharan Aljanoub as participants selected randomly. A test is composed of writing, speaking and critical thinking tests –a retest was administered and descriptive analysis was done. The findings of the study have revealed that the implementation of banking education and teacher-centeredness impact students' studying intensive English course achievement negatively. The study concludes that banking education and teacher-centeredness should be eradicated in the educational system at KKU. Instead, interactive teaching and student-centeredness should be adopted in English classes Instead student-centeredness approach and interactive teaching and learning should be implemented.
Hubungan Riwayat Bblr (Berat Badan Lahir Rendah) Dengan Kejadian Stunting Di Kabupaten Pandeglang
Authors: Trisiswati Maya , Mardhiyah Dian , Maulidya Sari Siti 
Published: April 2022

Stunting merupakan gangguan pertumbuhan yang terjadi akibat kondisi kekurangan gizi kronis atau penyakit infeksi kronis pada bayi / anak di bawah lima tahun, ditandai dengan nilai z-scorenya kurang dari -2SD/standar deviasi (stunted) dan kurang dari –3SD (severely stunted). Berat badan saat lahir merupakan salah satu indikator dalam tumbuh kembang anak hingga masa dewasanya dan menggambarkan status gizi yang diperoleh janin selama dalam kandungan. BBLR ialah Berat Badan Lahir Rendah kurang dari 2.500 gram, tanpa memandang masa gestasi. Data prevalensi balita stunting WHO, Indonesia termasuk ke dalam negara ketiga dengan prevalensi tertinggi di regional Asia Tenggara/South-East Asia Regional (SEAR), dengan rata-rata 36,4% tahun 2005-2017. Kabupaten Pandeglang memiliki prevalensi stunting tertinggi di Provinsi Banten, 21,9% untuk BADUTA (bayi dibawah dua tahun). Penelitian ini merupakan penelitian deskriptif analitik. Rancangan penelitian adalah cross sectional. Responden tidak BBLR menjadi stunting sebanyak 170 orang atau 25.6% tidak stunting 493 orang atau 74.4%, BADUTA BBLR sebanyak 16 orang atau 35,6% mengalami stunting sedangkan 29 orang atau 64.4% tidak mengalami stunting dengan p-value 0.144 atau p-value lebih dari 0,05, OR 1,6 dengan 95% CI (0.848 – 3.019) atau CI. Hasil analisis bivariate menunjukan tidak ada hubungan yang signifikan atau bermakna antara BBLR dengan keajdian stunting di 10 desa Kabupaten Pandeglang
A Finite Element Model of Cerebral Vascular Injury for Predicting Microbleeds Location
Authors: Duckworth Harry , Azor Adriana , Wischmann Nikolaus , Zimmerman Karl A. , Tanini Ilaria , Sharp David J. , Ghajari Mazdak 
Published: April 2022

Finite Element (FE) models of brain mechanics have improved our understanding of the brain response to rapid mechanical loads that produce traumatic brain injuries. However, these models have rarely incorporated vasculature, which limits their ability to predict the response of vessels to head impacts. To address this shortcoming, here we used high-resolution MRI scans to map the venous system anatomy at a submillimetre resolution. We then used this map to develop an FE model of veins and incorporated it in an anatomically detailed FE model of the brain. The model prediction of brain displacement at different locations was compared to controlled experiments on post-mortem human subject heads, yielding over 3,100 displacement curve comparisons, which showed fair to excellent correlation between them. We then used the model to predict the distribution of axial strains and strain rates in the veins of a rugby player who had small blood deposits in his white matter, known as microbleeds, after sustaining a head collision. We hypothesised that the distribution of axial strain and strain rate in veins can predict the pattern of microbleeds. We reconstructed the head collision using video footage and multi-body dynamics modelling and used the predicted head accelerations to load the FE model of vascular injury. The model predicted large axial strains in veins where microbleeds were detected. A region of interest analysis using white matter tracts showed that the tract group with microbleeds had 95th percentile peak axial strain and strain rate of 0.197 and 64.9 s−1 respectively, which were significantly larger than those of the group of tracts without microbleeds (0.163 and 57.0 s−1). This study does not derive a threshold for the onset of microbleeds as it investigated a single case, but it provides evidence for a link between strain and strain rate applied to veins during head impacts and structural damage and allows for future work to generate threshold values. Moreover, our results suggest that the FE model has the potential to be used to predict intracranial vascular injuries after TBI, providing a more objective tool for TBI assessment and improving protection against it.
Emulation of a Target Trial From Observational Data to Compare Effectiveness of Casirivimab/Imdevimab and Bamlanivimab/Etesevimab for Early Treatment of Non-Hospitalized Patients With COVID-19
Authors: Mazzotta Valentina , Cozzi-Lepri Alessandro , Colavita Francesca , Lanini Simone , Rosati Silvia , Lalle Eleonora , Mastrorosa Ilaria , Cimaglia Claudia , Vergori Alessandra , Bevilacqua Nazario , Lapa Daniele , Mariano Andrea , Bettini Aurora , Agrati Chiara , Piselli Pierluca , Girardi Enrico , Castilletti Concetta , Garbuglia Anna Rosa , Vaia Francesco , Nicastri Emanuele , Antinori Andrea 
Published: April 2022

ObjectivesComparative analysis between different monoclonal antibodies (mAbs) against SARS-CoV-2 are lacking. We present an emulation trial from observational data to compare effectiveness of Bamlanivimab/Etesevimab (BAM/ETE) and Casirivimab/Imdevimab (CAS/IMD) in outpatients with early mild-to-moderate COVID-19 in a real-world scenario of variants of concern (VoCs) from Alpha to Delta.MethodsAllocation to treatment was subject to mAbs availability, and the measured factors were not used to determine which combination to use. Patients were followed through day 30. Viral load was measured by cycle threshold (CT) on D1 (baseline) and D7.Primary outcome was time to COVID-19-related hospitalization or death from any cause over days 0-30. Weighted pooled logistic regression and marginal structural Cox model by inverse probability weights were used to compare BAM/ETE vs. CAS/IMD. ANCOVA was used to compare mean D7 CT values by intervention. Models were adjusted for calendar month, MASS score and VoCs. We evaluated effect measure modification by VoCs, vaccination, D1 CT levels and enrolment period.ResultsCOVID19-related hospitalization or death from any cause occurred in 15 of 237 patients in the BAM/ETE group (6.3%) and in 4 of 196 patients in the CAS/IMD group (2.0%) (relative risk reduction [1 minus the relative risk] 72%; p=0.024). Subset analysis carried no evidence that the effect of the intervention was different across stratification factors. There was no evidence in viral load reduction from baseline through day 7 across the two groups (+0.17, 95% -1.41;+1.74, p=0.83). Among patients who experienced primary outcome, none showed a negative RT-PCR test in nasopharyngeal swab (p=0.009) and 82.4% showed still high viral load (p&lt;0.001) on D7.ConclusionsIn a pre-Omicron epidemiologic scenario, CAS/IMD reduced risk of clinical progression of COVID-19 compared to BAM/ETE. This effect was not associated with a concomitant difference in virological response.
Comprehensive Molecular Profiling of Colorectal Cancer With Situs Inversus Totalis by Next-Generation Sequencing
Authors: Li Hongsen , Gong Liu , Cheng Huanqing , Wang Huina , Zhang Xiaochen , Rao Chuangzhou , Song Zhangfa , Wang Da , Lou Haizhou , Lou Feng , Cao Shanbo , Pan Hongming , Fang Yong 
Published: April 2022

BackgroundColorectal cancer (CRC) is one of the most prevalent malignances worldwide. However, CRC with situs inversus totalis (SCRC) is extremely rare, and molecular characterization of this disease has never been investigated.MethodsTumor tissue samples from 8 patients with SCRC and 33 CRC patients without situs inversus totalis (NSCRC) were subjected to multigene next-generation sequencing.ResultsThe most frequently mutated genes in SCRC were APC, TP53, CHEK2, MDC1, GNAQ, KRAS, and SMAD4. A high frequency of SCRC tumors had mutations in DNA damage repair genes. Single amino acid substitutions in the DNA damage repair genes caused by continuous double base substitution was identified in the majority of this population. Furthermore, mutational profiles showed notable differences between the SCRC and NSCRC groups. In particular, CHEK2, MDC1, GNAQ, SMAD4, BRCA1, HLA-B, LATS2, and NLRC5 mutations were more frequently observed in SCRC patients. The mutation loci distributions of KRAS in the SCRC cohort differed from that of the NSCRC cohort. Additionally, differences in the targeted genomic profiles and base substitution patterns were observed between the two groups.ConclusionsThese findings comprehensively revealed a molecular characterization of SCRC, which will contribute to the development of personalized therapy and improved clinical management of SCRC patients.
Cost-Effectiveness of Nivolumab Plus Chemotherapy vs. Chemotherapy as First-Line Treatment for Advanced Gastric Cancer/Gastroesophageal Junction Cancer/Esophagel Adenocarcinoma in China
Authors: Shu Yamin , Ding Yufeng , Zhang Qilin 
Published: April 2022

ObjectiveThe purpose of this study was to evaluate the cost-effectiveness of nivolumab plus chemotherapy vs. chemotherapy as first-line therapy in patients with advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma from the perspective of the Chinese healthcare system.MethodsThis economic evaluation used a state-transition Markov model to assess the cost and effectiveness of nivolumab plus chemotherapy vs. chemotherapy as first-line treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma. The characteristics of patients in the model came from a phase 3 open-label randomized clinical trial (CheckMate 649). Key clinical data were based on the CheckMate 649 trial conducted from March 2017 to April 2019, and costs and utilities were collected from the published literature. The total cost of treatment per patient, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratio (ICER) were calculated for the two treatment strategies. Deterministic sensitivity analysis and probabilistic sensitivity analysis were performed.ResultsIn the baseline analysis, the incremental effectiveness and cost of nivolumab plus chemotherapy vs. chemotherapy were 0.28 QALYs and $78,626.53, resulting in an ICER of $278,658.71/QALY, higher than the willingness-to-pay (WTP) threshold of China ($31,498.70/QALY). The model was sensitive to the duration of progression-free survival (PFS) for the nivolumab plus chemotherapy group, the cost of nivolumab per 100 mg, and the utility of PFS.ConclusionNivolumab plus chemotherapy was clearly not a cost-effective treatment strategy compared with chemotherapy as first-line therapy for patients with advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma in China. Reducing the price of nivolumab may improve its cost-effectiveness.
Angiotensin II Receptor Blocker Associated With Less Outcome Risk in Patients With Acute Kidney Disease
Authors: Wu Vin-Cent , Lin Yu-Feng , Teng Nai-Chi , Yang Shao-Yu , Chou Nai-Kuan , Tsao Chun-Hao , Chen Yung-Ming , Chueh Jeff S , Chen Likwang 
Published: April 2022

Objective: The aim of this study was to explore the respective use of angiotensin-converting-enzyme inhibitors (ACEis) or angiotensin receptor blockers (ARBs) on the outcomes of patients who could be weaned from dialysis-requiring acute kidney injury (AKI-D).Methods: This case–control study enrolled 41,731 patients who were weaned from AKI-D for at least 7 days from Taiwan’s National Health Insurance Administration. We further grouped AKI-D patients according to ACEi and ARB use to evaluate subsequent risks of all-cause mortality and re-dialysis. The outcomes included the all-cause mortality and new-onset of end-stage kidney disease (ESKD; re-dialysis) following withdraw from AKI-D.Results: A total of 17,141 (41.1%) patients surviving AKI-D could be weaned from dialysis for at least 7 days. The overall events of mortality were 366 (48.9%) in ACEi users, 659 (52.1%) in ARB users, and 6,261 (41.3%) in ACEi/ARB nonusers, during a mean follow-up period of 1.01 years after weaning from AKI-D. In regard to all-cause of mortality, pre-dialysis ARB users had lower incidence than ACEi users [hazard ratio (HR 0.82), p = 0.017]. Compared with ACEi/ARB nonusers, continuing ARB users had a significantly low risk of long-term all-cause mortality (adjusted hazard ratio 0.51, p = 0.013) after propensity score matching. However, new users of ACEi at the acute kidney disease (AKD) period had a higher risk of re-dialysis after weaning than ACEi/ARB nonusers (aHR 1.82, p &lt; 0.001), whereas neither ACEi nor ARB users confronted significantly increased risks of hyperkalemia after weaning.Conclusions: Compared with patients without ACEi/ARB, those continuing to use ARB before the event and after weaning had low all-cause mortality, while new users of ACEi at AKD had increased risk of re-dialysis. AKI-D patients continuing to use ACEi or ARB did not have higher risk of hyperkalemia. Future prospective randomized trials are expected to confirm these findings.
Xuedan Sustained Release Pellets Ameliorate Dextran Sulfate Sodium–Induced Ulcerative Colitis in Rats by Targeting Gut Microbiota and MAPK Signaling Pathways
Authors: Zhang Yingchun , Feng Dan , Zeng Yue , Zhang Hanyu , Du Xiaohong , Fu Yang , Wang Xinhui , Lian Dingyue , Wang Ruikang , Xiao Hongyu , Wei Ning , Zhai Fuqiang , Liu Hanru 
Published: April 2022

Cucurbitacins have a variety of bioactivities, such as anticancer, anti-inflammatory, antidepressant-like, and antiviral effects, but their pharmacological effect in ulcerative colitis (UC) has not been reported until now. Thus, this study aims to investigate the preventive effects of Xuedan sustained release pellets (XSPs) on UC rats and the underlying mechanisms. XSPs were prepared by extracting cucurbitacins from Hemsleya. Experimental UC rats were induced by the intake of 4% dextran sulfate sodium (DSS) for a week and treated with different doses of XSP (0.95, 1.90, and 3.8 mg/kg). The body weight, colon length, disease activity index (DAI), and histological changes of colonic tissue were measured. In addition, the expressions of pro-inflammatory cytokines were detected by using the enzyme-linked immunosorbent assay. Pathways involved in the intestinal inflammation were targeted by RNA-sequencing. Moreover, the changes of gut microbial diversity and composition were analyzed by the 16SrNA analysis and the contents of short-chain fatty acids (SCFAs) were detected by GC-MS. The results revealed that XSP intervention greatly restored the weight loss and colonic shortening (p &lt; 0.05) and reduced the raised DAI scores, myeloperoxidase, and nitric oxide activities in UC in rats (p &lt; 0.05). XSP administration also downregulated the protein levels of pro-inflammatory factors IL-1β, IL-6, and TNF-α. Notably, it was found that XSP considerably suppressed the activation of the MAPK signaling pathway. In addition, XSP treatment improved the balance of gut microbiota that was disturbed by DSS. The beneficial bacteria Lachnospiraceae_NK4A136 group and Lactobacillus at the genus level significantly increased in the XSP group, which had decreased with the use of DSS (p &lt; 0.05). Pathogenic bacteria including Escherichia–Shigella and Bacteroides in UC in rats were reduced by XSP intervention. Furthermore, XSP significantly elevated the production of SCFAs in UC in rats (p &lt; 0.05). These alterations in inflammatory status were accompanied with changes in gut microbiota diversity and SCFA production. In conclusion, XSP exhibited protective effects against DSS-induced UC in rats. XSP treatment decreased inflammation via modulation of gut microbiota composition and SCFA production.
Observation of Voriconazole in the Treatment of Liver Failure Complicated With Invasive Pulmonary Fungal Infection Induced by Chinese Patent Medicine in Teenagers: 2 Case Reports
Authors: Su Qian , Pan Jinjin , Zhang Li , Xia Lingling , Gao Yufeng , Li Jiabin 
Published: April 2022

Background: Drug-induced liver injury (DILI) caused by Chinese patent medicines is increasing in China. The incidence of invasive fungal infections (IFIs) is increasing due to the suppression of the immune function in greater numbers of patients. Invasive procedures such as deep vein catheterization and the use of glucocorticoids are also predisposing factors to IFIs. The clinical presentation of IFI in teenagers is often atypical, challenging to diagnose, difficult to treat, and associated with a high fatality rate.Case presentation: Herein, we report 2 teenagers with liver failure after receiving oral Chinese patent medicines. Case 1 was a 14-year-old boy who presented with subacute liver failure who had been administered a Chinese patent medicine that included acetaminophen. Administration of glucocorticoids and non-bioartificial liver treatment improved his condition. Subsequently, invasive pulmonary Aspergillus (IPA) was diagnosed and was successfully treated with voriconazole for 85 days. Case 2 was a 17-year-old girl who presented with acute liver failure after taking the Chinese patent medicine QubaiBabuqi tablets for vitiligo. Chest computed tomography (CT) revealed multiple pulmonary nodules with an intermittent low-grade fever, and she was diagnosed with IPA. She was initially treated with caspofungin (23 days) and then voriconazole (406 days) for 429 days. Her liver function returned to normal, and lung lesions were absorbed in 2 patients. At the same time, two to three histopathological examinations of the liver biopsy showed that the drug-induced autoimmune-like phenomena could be improved by glucocorticoid therapy.Conclusion: To the best of our knowledge, this is the first report of the successful treatment of 2 cases of liver failure (Child–Pugh class C) caused by Chinese patent medicines complicated with IPA in teenagers. Drug-induced autoimmune-like phenomena could be improved by glucocorticoid therapy.
A Novel Epithelial-Mesenchymal Transition Gene Signature Correlated With Prognosis, and Immune Infiltration in Hepatocellular Carcinoma
Authors: Kong Weihao , Mao Zhongxiang , Han Chen , Ding Zhenxing , Yuan Qianqian , Zhang Gaosong , Li Chong , Wu Xuesheng , Chen Jia , Guo Manyu , Hong Shaocheng , Yu Feng , Liu Rongqiang , Wang Xingyu , Zhang Jianlin 
Published: April 2022

Background: Although many genes related to epithelial-mesenchymal transition (EMT) have been explored in hepatocellular carcinoma (HCC), their prognostic significance still needs further analysis.Methods: Differentially expressed EMT-related genes were obtained through the integrated analysis of 4 Gene expression omnibus (GEO) datasets. The univariate Cox regression and Lasso Cox regression models are utilized to determine the EMT-related gene signature. Based on the results of multivariate Cox regression, a predictive nomogram is established. Time-dependent ROC curve and calibration curve are used to show the distinguishing ability and consistency of the nomogram. Finally, we explored the correlation between EMT risk score and immune immunity.Results: We identified a nine EMT-related gene signature to predict the survival outcome of HCC patients. Based on the EMT risk score’s median, HCC patients in each dataset were divided into high and low-risk groups. The survival outcomes of HCC patients in the high-risk group were significantly worse than those in the low-risk group. The prediction nomogram based on the EMT risk score has better distinguishing ability and consistency. High EMT risk score was related to immune infiltration.Conclusion: The nomogram based on the EMT risk score can reliably predict the survival outcome of HCC patients, thereby providing benefits for medical decisions.