bluuebunny/crossref_metadata_2025_split huggingface dataset:
Auto-generated Relative Importance for Multi-agent Inducing Variable in Uncertain and Preference Involved Evaluation
Authors: Zhou Meng-Die , Chen Zhen-Song , Jiang Jiani , Qian Gang , García-Zamora Diego , Dutta Bapi , Zhan Qiuyan , Jin LeSheng 
Published: December 2022

AbstractInducing information and bi-polar preference-based weights allocation and relevant decision-making are one important branch of Yager’s decision theory. In the context of basic uncertain information environment, there exist more than one inducing factor and the relative importance between them should be determined. Some subjective methods require decision makers to indicate the bi-polar preference extents for each inducing factor as well as the relative importance between all the involved inducing factors. However, although the bi-polar preference extents for inducing factors can often be elicited, sometimes decision makers cannot provide the required relative importance. This work presents some approaches to address such problem in basic uncertain information environment. From the mere bi-polar preference extents offered by decision makers, we propose three methods, statistic method, distance method and linguistic variable method, to derive relative importance between different inducing factors, respectively. Each of them has advantages and disadvantages, and the third method serves as a trade-off between the first two methods. The rationale of preference and uncertainty involved evaluation is analyzed, detailed evaluation procedure is presented, and numerical example is given to illustrate the proposals.
Clinical outcomes associated with guideline-discordant management of asymptomatic bacteriuria and urinary tract infection in hospitalized patients with neurogenic bladder
Authors: Fitzpatrick Margaret A. , Wirth Marissa , Nguyen Jimmy , Suda Katie J. , Weaver Frances M. , Burns Stephen , Collins Eileen , Safdar Nasia , Patel Ursula , Evans Charlesnika T. 
Published: December 2022

Abstract

Objective:
To compare clinical outcomes associated with appropriate and inappropriate management of asymptomatic bacteriuria (ASB) and urinary tract infection (UTI) among inpatients with neurogenic bladder (NB).

Design:
Multicenter, retrospective cohort.

Setting:
The study was conducted across 4 Veterans’ Affairs hospitals.

Participants:
The study included veterans with NB due to spinal cord injury or disorder (SCI/D), multiple sclerosis (MS), or Parkinson’s disease (PD) hospitalized between January 1, 2017, and December 31, 2018, with diagnosis of ASB or UTI.

Interventions:
In a medical record review, we classified ASB and UTI diagnoses and treatments as appropriate or inappropriate based on national guidelines.

Main outcome measures:
Frequencies of Clostridioides difficile infection, acute kidney injury, 90-day hospital readmission, postculture length-of-stay (LOS), and multidrug-resistant organisms in subsequent urine cultures were compared between those who received appropriate and inappropriate management.

Results:
We included 170 encounters with ASB (30%) or UTI (70%) diagnoses occurring for 166 patients. Overall, 86.1% patients were male, 47.6% had SCI/D and 77.6% used bladder catheters. All ASB encounters had appropriate diagnoses, and 96.1% had appropriate treatment. In contrast, 37 UTI encounters (31.1%) had inappropriate diagnoses and 61 (51.3%) had inappropriate treatment, including 30 encounters with true ASB. Among patients with SCI/D or MS, appropriate ASB or UTI diagnosis was associated with a longer postculture LOS (median, 14 vs 7.5 days; P = .02). We did not detect any significant associations between appropriate versus inappropriate diagnosis and treatment and other outcomes.

Conclusions:
Almost one-third of UTI diagnoses and half of treatments in hospitalized patients with NB are inappropriate. Opportunities exist to improve ASB and UTI management in patients with NB to minimize inappropriate antibiotic use.
Closing the treatment gap for alcohol use disorders in low- and middle-income countries
Authors: Nadkarni Abhijit , Gandhi Yashi , Bhatia Urvita , Velleman Richard 
Published: December 2022

Abstract
The alcohol-attributable disease burden is greater in low- and middle-income countries (LMICs) as compared to high-income countries. Despite the effectiveness of interventions such as health promotion and education, brief interventions, psychological treatments, family-focused interventions, and biomedical treatments, access to evidence-based care for alcohol use disorders (AUDs) in LMICs is limited. This can be explained by poor access to general health and mental health care, limited availability of relevant clinical skills among health care providers, lack of political will and/or financial resources, historical stigma and discrimination against people with AUDs, and poor planning and implementation of policies. Access to care for AUDs in LMICs could be improved through evidence-based strategies such as designing innovative, local and culturally acceptable solutions, health system strengthening by adopting a collaborative stepped care approach, horizontal integration of care into existing models of care (e.g., HIV care), task sharing to optimise limited human resources, working with families of individuals with AUD, and leveraging technology-enabled interventions. Moving ahead, research, policy and practice in LMICs need to focus on evidence-based decision-making, responsiveness to context and culture, working collaboratively with a range of stakeholders to design and implement interventions, identifying upstream social determinants of AUDs, developing and evaluating policy interventions such as increased taxation on alcohol, and developing services for special populations (e.g., adolescents) with AUDs.
Using quantitative methods to understand leaf epidermal development
Authors: Kuan Chi , Yang Shao-Li , Ho Chin-Min Kimmy 
Published: December 2022

Abstract
As the interface between plants and the environment, the leaf epidermis provides the first layer of protection against drought, ultraviolet light, and pathogen attack. This cell layer comprises highly coordinated and specialised cells such as stomata, pavement cells and trichomes. While much has been learned from the genetic dissection of stomatal, trichome and pavement cell formation, emerging methods in quantitative measurements that monitor cellular or tissue dynamics will allow us to further investigate cell state transitions and fate determination in leaf epidermal development. In this review, we introduce the formation of epidermal cell types in Arabidopsis and provide examples of quantitative tools to describe phenotypes in leaf research. We further focus on cellular factors involved in triggering cell fates and their quantitative measurements in mechanistic studies and biological patterning. A comprehensive understanding of how a functional leaf epidermis develops will advance the breeding of crops with improved stress tolerance.
Interaction between dietary potassium intake and TNF-α rs1800629 genetic polymorphism in gastric cancer risk: a case–control study conducted in Korea
Authors: Tran Tao Thi , Gunathilake Madhawa , Lee Jeonghee , Choi Il Ju , Kim Young-Il , Kim Jeongseon 
Published: December 2022

AbstractMineral consumption has been suggested to have an impact on gastric cancer (GC) prevention. However, the protective effect of potassium against gastric carcinogenesis remains inconclusive. The causal link between inflammation and cancer is well established. Notably, potassium intake and potassium channels may play certain roles in regulating the production of TNF-α (TNF-α). We aimed to determine whether dietary potassium intake is related to the risk of GC. We further observed whether this association was modified by TNF-α rs1800629. We designed a case–control study comprising 377 GC cases and 756 controls. Information on dietary potassium intake was collected using a semiquantitative food frequency questionnaire. Genotyping was performed by the Affymetrix Axiom Exom 319 Array platform. Unconditional logistic regression models were used to assess associations. A significantly reduced GC risk was found for those who consumed higher dietary potassium levels (OR = 0·63, 95 % CI = 0·45, 0·89, P for trend = 0·009). In the dominant model, we observed a non-significant association between TNF-α rs1800629 and GC risk (OR = 1·01, 95 % CI = 0·68, 1·49). In females, those who were homozygous for the major allele (G) of rs1800629 with a higher intake of dietary potassium exhibited a decreased risk of GC (OR = 0·40, 95 % CI = 0·20, 0·78, P interaction = 0·041). This finding emphasises the beneficial effect of potassium intake on GC prevention. However, this association could be modified by TNF-α rs1800629 genotypes. A greater protective effect was exhibited for females with GG homozygotes and high potassium intake.
A novel approach in the prevention of mastitis: electrical teat dipping
Authors: Risvanli Ali , Safak Tarik , Yilmaz Oznur , Yuksel Burak , Saat Nevzat , Tanyeri Burak 
Published: December 2022

AbstractTeat dipping is widely used in dairy cattle, especially to protect against contagious mastitis. Here we determine the effect of the device called ‘Electrical Teat Dipping’ (ETD), which was developed by combining teat dipping application and electrical field stimulation technique on teats. For this purpose, the front teats of 100 Holstein breed milking cows were evaluated in two groups, with ETD being applied once to the left front teat of these cows, and conventional teat dipping (CTD) being applied once to the right front teat, both after milking. Ultrasonographic measurements of the teats were made before milking and after teat dipping. We found that the width of the teat canal (1.88 ± 0.07 mm) in the teat using ETD was narrower after the application compared to those with CTD (2.28 ± 0.05 mm). Based on our findings, we conclude that the effects of ETD on the teat are very positive and can potentially be used as a new approach in the preventative control of mastitis in cows.
Evidence that host ecology drives first intermediate host use in the Didymozoidae (Trematoda: Hemiuroidea): an asexual infection in a vermetid (Gastropoda)
Authors: Louvard C. , Corner R. D. , Cutmore S. C. , Cribb T. H. 
Published: December 2022

Abstract
The Didymozoidae (Trematoda: Hemiuroidea) is among the most speciose trematode families, known from a wide range of marine teleost fishes. Despite their richness, however, didymozoid life cycles are unusually poorly known; only two first intermediate hosts are known, a marine bivalve (Anadara trapezia) and a pelagic gastropod (Firoloida desmarestia). This study uses multi-locus molecular sequence data to identify a novel first intermediate host for the family, a sessile gastropod of the genus Thylacodes Guettard (Vermetidae). The didymozoid infection is not identified to species but, based on molecular phylogenetic analyses, it is close to Saccularina magnacetabula Louvard et al., 2022, which uses a bivalve as a first intermediate host. The distribution of known first intermediate hosts of didymozoids (a bivalve, a holoplanktonic gastropod and a sessile gastropod that feeds with the use of mucus nets) suggests that first intermediate host use within the Didymozoidae has been opportunistically driven by the trophic ecology of potential mollusc hosts and has involved significant host-switching events.
Bat diversity is driven by elevation and distance to the nearest watercourse in aterra firmeforest in the northeastern Brazilian Amazon
Authors: Ferreira Marcelo Martins , Xavier Bruna da Silva , Bobrowiec Paulo Estefano Dineli , de Castro Isaí Jorge , Hilário Renato , da Cunha Alan Cavalcanti , Oliveira Leidiane Leão , Toledo José Júlio de , Carvalho William Douglas 
Published: December 2022

AbstractVariations in environmental conditions along gradients play an important role in species distribution through environmental filtering of morphological and physiological traits; however, their effects on bat diversity remain poorly understood. Here, we investigate the effect of the distance to the nearest watercourse, terrain elevation, vegetation clutter, basal area and canopy height on taxonomic, functional and phylogenetic diversity and on the predominance of some functional traits (body mass, wing morphology and trophic level) of bat assemblages (phyllostomid and mormoopid bats) in aterra firmeforest, in the northeastern Brazilian Amazon. We captured bats using mist nets in 15 permanent plots over a 25 km2area of continuous forest. We captured 279 individuals belonging to 28 species with a total of 77.760 m2.h of sampling effort. Our results showed that bat richness increases as a function of distance to the nearest watercourse and that the assemblage also changes, with more diverse taxonomic and functional groups in areas further from the watercourse. Furthermore, elevation positively affects species richness, and the basal area of the forest positively influences the average body mass of bats. Taken together, our results demonstrate that subtle variations in the environmental conditions along a local scale gradient impact on the main dimensions of bat diversity in primary forests.
Beyond colonial urbanism: state power, global connections and fragmented land regimes in twentieth-century Hyderabad city
Authors: Beverley Eric Lewis 
Published: December 2022

AbstractUrban histories of modern South Asia have centred on British Indian cities and the reign of colonial urbanism, with dependence on metropolitan imperatives and models regarded as givens. Focusing on Hyderabad, one of the subcontinent's five largest cities and capital of an autonomous princely state throughout the colonial era, this article establishes the analytical utility of princely urbanism as a framework for writing the history of South Asian cities. Characterized by state-directed planning, transnational urbanist networks and multiple overlapping property regimes, this mode of city development and its resonance points to hidden genealogies of modern urbanism.
L1-Korean speakers’ definiteness processing in L2 English: A visual world paradigm eye tracking study
Authors: Ahn Hyunah , Song Mi-Jeong 
Published: December 2022

AbstractThis study investigated whether L1-Korean L2-English speakers could use (in)definiteness to predict unmentioned (non-)unique referents. In previous studies on the topic, methodological considerations made it difficult to separate the effects of grammar from the effects of non-linguistic knowledge. We used a visual world paradigm eye-tracking task to resolve such issues and designed stimuli that focused only on (in)definiteness. Participants’ eye movements were recorded as they heard “Click on the/a blue circle.” L1 and advanced L2 speakers used definiteness information to predict unique referents before the critical noun (circle) was heard while indefinite articles were not utilized to the same extent. Intermediate L2 speakers relied heavily on color words, not articles, to locate a referent. The results imply that predicting a referent solely based on definiteness (without real-world knowledge) requires substantial advancement in L2 development, and indefinite articles do not predict non-unique referents as clearly as definite articles predict unique referents.
Dentistry responding to domestic violence and abuse: a dental, practice-based intervention and a feasibility study for a cluster randomised trial
Authors: Coulthard Paul , Feder Gene , Evans Maggie A. , Johnson Medina , Walsh Tanya , Robinson Peter G. , Armitage Christopher J. , Barbosa Estela , Tickle Martin , Femi-Ajao Omolade 
Published: December 2022

AbstractObjectives Assess the feasibility of using the Identification and Referral to Improve Safety (IRIS) intervention in a general dental practice setting and evaluating it using a cluster randomised trial design. IRIS is currently used in general medical practices to aid recognition and support referral into specialist support of adults presenting with injuries and other presenting factors that might have resulted from domestic violence and abuse. Also, to explore the feasibility of a cluster randomised trial design to evaluate the adapted IRIS.Design Feasibility study for a cluster randomised trial of a practice-based intervention.Setting Greater Manchester general dental practices.Results It was feasible to adapt the IRIS intervention used in general medical practices to general dental practices in terms of training the clinical team and establishing a direct referral pathway to a designated advocate educator. General dental practices were keen to adopt the intervention, discuss with patients when presented with the opportunity and utilise the referral pathway. However, we could not use practice IT software prompts and data collection as for general practitioners because there is no unified dental IT system and because coding in dentistry for diagnoses, procedures and outcomes is not developed in the UK.Conclusion While it was feasible to adapt elements of the IRIS intervention to general dental practice and there was general acceptability, we did not have enough empirical data to plan a definitive cluster randomised trial design to evaluate the IRIS-dentistry intervention within general dental practices.
Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion
Authors: Harms Julia , Lüttgenau Simona Mareike , Emming Christin , Guske Justine , Weber Katrin , Wagner Thomas , Schowe Larissa , Nedvetsky Pavel , Krahn Michael P. 
Published: December 2022

AbstractDownregulation of cell–cell adhesion and increased motility are prerequisites for the metastasis of cancer cells. We have recently shown that downregulation of the tight junction adapter protein Pals1 in colorectal cancer cells results in an increase of cell migration, invasion, and metastasis due to the enhanced activation of Arf6 and Rac1. We now reveal a redundancy between the Arf6-GAP SMAP1 and Pals1 in regulating Arf6 activity and thereby Rac1-dependent cell migration. The gene encoding SMAP1 is frequently disrupted in microsatellite instable colorectal cancer specimen and cell lines. In cells expressing SMAP1, deletion of Pals1 leads to disturbed formation of tight junctions but has no impact on Arf6 activity and cell migration. In contrast, inactivation of both SMAP1 and Pals1 results in enhanced Arf6/Rac1 activity and increased cell migration and invasion. Furthermore, analyzing patient cohorts, we found a significant decrease in patient’s survival when both genes were downregulated, in contrast to cases, when expression of only one of both genes was affected. Taken together, we identified a redundancy between SMAP1 and Pals1 in the regulation of activation of Arf6/Rac1, thereby controlling cell migration, invasion, and metastasis of colorectal cancer cells.
circPLIN2 promotes clear cell renal cell carcinoma progression by binding IGF2BP proteins and miR-199a-3p
Authors: Zhao Bin , Huang Cong , Pan Jie , Hu Hao , Liu Xiaojuan , Zhang Kaoyuan , Zhou Fenli , Shi Xin , Wu Jun , Yu Bo , Chen Xiaofan , Zhang Wei 
Published: December 2022

AbstractRecent evidence has indicated that circular RNAs (circRNAs), a novel type of regulatory RNA, play important roles in the development and progression of various cancers. However, the potential regulatory roles and molecular mechanisms of circRNAs in clear cell renal cell carcinoma (ccRCC) remain largely unclear. Here, we explored circRNA expression profiles in 10 paired samples of RCC (including cancer tissues and surrounding tissues) from the Gene Expression Omnibus (GEO) datasets GSE124453 and GSE108735. We initially identified hsa_circ_0086457, designated circPLIN2, derived from exons 4 to 5 of the PLIN2 gene. We observed that circPLIN2 was preferentially located in the cytoplasm and was more stable than its linear counterpart PLIN2. circPLIN2 was significantly upregulated in ccRCC cells and tissues, and its overexpression was correlated with higher clinical stage and worse prognosis for ccRCC patients. Moreover, gain- and loss-of-function assays indicated that circPLIN2 promoted ccRCC cell proliferation, migration, and invasion in vitro and ccRCC tumor growth and metastasis in vivo. Mechanistically, circPLIN2 not only increased the stability of the c-Myc and MARCKSL1 mRNAs by binding to the KH domains of IGF2BP proteins but also competitively sponged miR-199a-3p to abolish the repressive effect of miR-199a-3p on ZEB1 expression, which ultimately resulted in ccRCC tumorigenesis and progression. Collectively, our results suggest that circPLIN2 may represent a promising diagnostic and prognostic biomarker and a potential therapeutic target for ccRCC patients.
Interpretable and tractable models of transcriptional noise for the rational design of single-molecule quantification experiments
Authors: Gorin Gennady , Vastola John J. , Fang Meichen , Pachter Lior 
Published: December 2022

AbstractThe question of how cell-to-cell differences in transcription rate affect RNA count distributions is fundamental for understanding biological processes underlying transcription. Answering this question requires quantitative models that are both interpretable (describing concrete biophysical phenomena) and tractable (amenable to mathematical analysis). This enables the identification of experiments which best discriminate between competing hypotheses. As a proof of principle, we introduce a simple but flexible class of models involving a continuous stochastic transcription rate driving a discrete RNA transcription and splicing process, and compare and contrast two biologically plausible hypotheses about transcription rate variation. One assumes variation is due to DNA experiencing mechanical strain, while the other assumes it is due to regulator number fluctuations. We introduce a framework for numerically and analytically studying such models, and apply Bayesian model selection to identify candidate genes that show signatures of each model in single-cell transcriptomic data from mouse glutamatergic neurons.
Colossal Nernst power factor in topological semimetal NbSb2
Authors: Li Peng , Qiu Pengfei , Xu Qing , Luo Jun , Xiong Yifei , Xiao Jie , Aryal Niraj , Li Qiang , Chen Lidong , Shi Xun 
Published: December 2022

AbstractToday solid-state cooling technologies below liquid nitrogen boiling temperature (77 K), crucial to quantum information technology and probing quantum state of matter, are greatly limited due to the lack of good thermoelectric and/or thermomagnetic materials. Here, we report the discovery of colossal Nernst power factor of 3800 × 10−4 W m−1 K−2 under 5 T at 25 K and high Nernst figure-of-merit of 71 × 10−4 K−1 under 5 T at 20 K in topological semimetal NbSb2 single crystals. The observed high thermomagnetic performance is attributed to large Nernst thermopower and longitudinal electrical conductivity, and relatively low transverse thermal conductivity. The large and unsaturated Nernst thermopower is the result of the combination of highly desirable electronic structures of NbSb2 having compensated high mobility electrons and holes near Fermi level and strong phonon-drag effect. This discovery opens an avenue for exploring material option for the solid-state heat pumping below liquid nitrogen temperature.