bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression Profile and Molecular Basis of Cyclin-Dependent Kinases Regulatory Subunit 2 in Endometrial Carcinoma Detected by Diversified Methods
Authors: Gao Li , Chen Gang , Liang Zi-Qian , Li Jian-Di , Li Dong-Ming , Tang Yu-Lu , Tang Deng , Huang Zhi-Guang , Chen Jun-Hong , Luo Jia-Yuan , Zeng Jiang-Hui , Dang Yi-Wu , Feng Zhen-Bo 
Published: May 2022

Purpose: Our purpose was to systematically appraise the clinicopathological significance and explore the molecular bases of CKS2 in endometrial carcinoma.Patients and Methods: We measured the clinicopathological significance of CKS2 using diverse methods of public RNA-seq, microarrays, and in-house tissue microarrays to investigate the molecular basis of CKS2 in endometrial carcinoma through upstream transcriptional analysis, immune infiltration correlation analysis, and co-expression analysis.Results: Both the analysis for public RNA-seq plus the microarray data and in-house tissue microarray confirmed the significant overexpression of CKS2 in a total of 1,021 endometrial carcinoma samples compared with 279 non-cancer endometrium samples (SMD = 2.10, 95% CI = 0.72–3.48). The upregulated CKS2 was significantly related to the lymph node metastasis and advanced clinical grade of endometrial carcinoma patients (p &lt; 0.001). Mutation types such as amplification and mRNA occurred with high frequency in the CKS2 gene in endometrial carcinoma patients. A series of miRNAs and transcription factors, such as hsa-miR-26a, hsa-miR-130a, hsa-miR-30, E2F4, MAX, and GABPA, were predicted to regulate the transcription and expression of CKS2. Significant links were found between CKS2 expression and the infiltration level of B cells, CD4+ T cells, and neutrophils in endometrial carcinoma. CKS2-coexpressed genes were actively involved in pathways such as the mitotic cell cycle process, PID aurora B pathway, and prolactin signaling pathway.Conclusion: The overexpressed CKS2 showed positive correlations with the clinical progression of endometrial carcinoma and was associated with various cancer-related biological processes and pathways, showing potential as a promising clinical biomarker for endometrial carcinoma.
Creative Tourism in Vila Nova de Foz Côa:
Authors: Liberato Dália , Vasconcelos Sandra , Paulos Adriana , Liberato Pedro , Melo Carla 
Published: May 2022

The tourism industry is constantly evolving, mostly due to the development of destinations and ever-changing tourist preferences. As a result, there has been a growing concern with promoting the use of existing resources and increasing profitability, particularly by encouraging diversity and creating local dynamics, moving beyond mass tourism. As tourists show a preference for more personalized and authentic experiences, there is also a growing demand for different experiences, paving the way for creative tourism and co-created activities.
Focusing on creative tourism in Vila Nova de Foz Côa, this paper aims to contribute to the understanding of the concept of creative tourism, as well as to identify its potential and impact on this region. Drawing from a literature review crosscutting the concepts of authenticity, creativity, and memorability, and on semi-structured interviews with local stakeholders, authors put forward a comprehensive analysis of the state of the art of local policies and available tourism activities, outlining key-areas for future development.
Overall, the main results of this research show that creative tourism in Vila Nova de Foz Côa is still at an early stage, and even though there is a common interest in developing this practice, it is necessary to improve the relationship between the different stakeholders, particularly when it comes to their communication and involvement in shared initiatives. On the other hand, given the potential of the region, it was also possible to identify prospective tourism products and activities, which can leverage future initiatives within this scope.
Shift work and quality of life on tourism, hospitality and restaurant industry: the Portuguese Context
Authors: Silva Susana , Martins Dora 
Published: May 2022

This research aims to study the association between shift work and the quality of life of workers. On the one hand quality of life includes several aspects of life (e.g. personal, family, marital or social) and serves as an important aspect in understanding the well-being of individuals in relationship with work life. On the other hand, shift work can be defined as any work organization of working hours that differs from the traditional diurnal work period. Furthermore, they are two factors strongly related, considering the increasing use of shift work in industry and services, especially from tourism, hospitality, and restaurant sectors, where shift work has the potential to disrupt different aspects of quality life.
The main objective of this study is to characterize the quality of life of shift workers in the tourism, hospitality, and restaurant industry. More specifically to characterize their workers’ personal life, family life, marital life, and social life.
Through an online questionnaire, data were collected from 122 shift workers linked to the tourism, hotel, and restaurant industry in Portugal. Data were analysed with IBM SPSS 27.0.
Results showed significant differences between workers from fixed and rotative shifts for the personal life satisfaction level whereas workers from fixed shifts reported higher levels of satisfaction. Workers in the morning shift reported higher levels of personal life and family life satisfaction than workers that are not in the morning shifts. There are no differences between the satisfaction levels for workers from the afternoon, night, or weekend shifts. There are no differences among the marital life satisfaction according to the kind of shift (fixed or rotative; morning, afternoon, night, or weekend shift).
This study provides several insights into the shift work theory and practice and contributes to knowledge of how human resource management will be reconfigured some practices to support the quality of life of shift workers in this industry. Limitations and future research suggestions are drawn in the last part of the paper.
Shaping the new normal:
Authors: Melo Carla , Melo António , Vasconcelos Sandra , Meneses Daniela 
Published: May 2022

The COVID-19 pandemic has created a worldwide crisis, which has had an impact on all economic sectors, having transformed social and consumption patterns. This crisis has been particularly difficult for the tourism industry, with uncertainty and the emergence of new consumer profiles and demands prompting swift reactions from policymakers and stakeholders.
Focussing on two sub-sectors of the Portuguese tourism industry – hospitality and events – this paper aims to identify the most relevant concerns and Crisis Management Strategies adopted in each of these sectors in the early stages of the pandemic, putting forward a multi-layered analysis, juxtaposing the different challenges faced by managers and how they were approached. Based on previous studies and on 14 semi-structured interviews with hotel and event managers, the authors adopted an exploratory qualitative approach as to record and categorize the interviewees’ perceptions, having established the transversal importance of resilience, flexibility, and technology for each sector’s recovery. Moreover, taking into account the singularity of each setting, the authors were also able to identify more specific sectorial categories, which have had an effect on both the decision-making and future outlooks for both the hospitality and events industries. Overall, despite being hopeful, hotel and event managers anticipate different recovery challenges, with the first highlighting the importance of soft skills, and the latter emphasizing the need to regain the public’s confidence, at the same time they will have to rethink their offer as to better address current needs and concerns.
Circular Economy in the Portuguese hotel industry – an Empirical Overview
Authors: Costa Berta 
Published: May 2022

The implementation of Circular Economy (CE) in the tourism industry, and more specifically in the hotel industry, is still in its early stages, as the debate on it has focused on the manufacturing sector, undervaluing the service area, namely the travel and tourism one, and their input to the transition to a CE paradigm. Although the hotel industry is one of the essential branches of the travel and tourism sector, there is little relevant scientific and empirical research available on the potential of such an implementation.
The Circular Economy construct has recently been gaining prominence as it has the potential to enhance the use of natural resources, in which the tourism and the hotel industry rely, to mitigate the emission of greenhouse gases, and to offer economic, environmental, and social business advantages and opportunities.
Making use of the results of a survey applied to the Portuguese hotel industry, this paper offers an analysis of this business’s awareness, attitude, enablers, benefits, challenges, and organisational performance with respect to the implementation of a Circular Economy approach. The results indicate that there is awareness regarding CE and its R-Principles and that some measures that may enhance the implementation of this concept are already being put into practice. There is also evidence that this economic approach is beneficial to companies, but support from all the actors (companies, government, stakeholders) is mandatory. The lack of investment in the CE implementation, policies focused in waste treatment, and the lack of promotion of circular design were identified as challenges. Acquiring new competencies as well as the reduction of the hotels’ carbon footprint were identified as the major predictive positive impacts of CE in the organisational performance of companies.
This research is a contribution to the existing literature on Circular Economy and to the conceptualization of CE within the hotel industry. In addition, to the theoretical contribution, the results of this study may also have empirical inputs for all the actors, and may also lead them to question the goals of their businesses and to examine thoroughly the environmental, social, and economic impact of their activities and operations, and ultimately act as catalysts to circularity.
Traditional Wine Landscape as a Rural Heritage:
Authors: Vaz de Freitas Isabel , Ramazanova Makhabbat , Albuquerque Helena , Soares Plínio 
Published: May 2022

Verde wine has a traditional and unique range of patterns and processes of cultivation that result from the interactions between communities and environments. The result of this interaction characterizes the local wine culture and rural landscape and creates diversity of characteristics developed through times. In this context, vineyard historical landscape assures the range of differentiation of rural places and contributes to the image of wine as a cultural asset based on the cultural heritage accumulation and the slow transformation of the landscapes. Safeguard this historical resilient landscape could reinforce the local character in his own unicity, authenticity, significance, diversity as a testimony of identity. Safeguard the historical wine landscape promotes the preservation of old techniques and fragile tangible and intangible heritage condemned to disappearance with the new standardized exploitations.
In this context, this study identifies the values of Verde wine landscape as a unique heritage in the world, aiming to safeguard this traditional landscape in the perspective of local communities with a tourism approach.
The methodological approach is to analyse, reflect and open the debate about Verde wine landscape elements and characteristics, to evaluate its importance and residents´ satisfaction, and to compare aesthetic perceptions with other elements of Verde wine landscape. Quantitative approach with survey questionnaires was applied to residents of the Verde wine region.
The results identify local wine culture and rural landscape and find the diversity of characteristics developed through times in different places. The residents find Verde wine landscape beautiful and attractive, and they are attached to the traditional Verde wine vineyards, quality of wine and quality of gastronomy.
The study reinforces the safeguard of this historical resilient landscape and the local character in his own unicity, authenticity, significance, diversity as a testimony of identity. It promotes the preservation of traditional and ancient techniques and fragile tangible and intangible heritage of Verde wine.
Developing Tourism–the path out of poverty for Uzbekistan
Authors: Babaev Shahboz , Johnston Tony 
Published: May 2022

Ending poverty in all of its forms by 2030 is the top priority goal of the United Nations Sustainable Development Goal (UNSDG). It is well known that the tourism industry can play a vital role in eradicating poverty. While the decline of global poverty is obvious, progress has slowed and even reversed because of COVID-19 and is expected to grow in the coming years. In recent years, tourism development in Uzbekistan has seen unprecedented growth.
Modern Uzbekistan history can be divided into two, both with very different political and economical approaches under the presidency of former president Islam Karimov and current leader Shavkat Mirziyoyev. Since 2016, Uzbekistan has begun an unprecedented political, economic and social transformation. The reforms the new president has started have been remarkable and are being seen as an opportunity to unlock the country’s potential. In ‘New Uzbekistan’, poverty is a new term following the President’s address to the parliament of Uzbekistan, in which he became the first Uzbek president in history to openly admit the existence of poverty in the country. In Uzbekistan, the population living below the poverty line accounts for about 12 to 15 percent, nearly 4 to 5 million people in the country are living for less than 10 to 13 thousand UZS a month.
Considering the challenges the world is facing with climate change, uncertain epidemic situations, countries with conflict (e.g. extremists taking over the government in Afghanistan in 2021), and authoritarian regimes (e.g. Kazakh protests in early 2022), it looks challenging to eradicate poverty by 2030 in Central Asia, particularly in Uzbekistan.
This research will initiate an exploration of both the present and potential future impacts of tourism on poverty alleviation in Uzbekistan. The overall aim of the research is to create a model for developing countries to reduce poverty by maximising the benefits of the tourism industry. The academic resources related to the topic of interest are sparse. Most studies seem to focus on tourism only and there is little or almost no evidence on the impacts of tourism on the poor in Uzbekistan. This paper has important implications for academics and proposes practical recommendations which will be beneficial to policymakers and tourism governance.
PENDIDIKAN ISLAM DALAM MEMBENTUK KARAKTER BERADAB MANUSIA MENURUT ADIAN HUSAINI
Authors: Mudhoffar Mudhoffar , Roihanah  
Published: May 2022

Pendidikan adalah usaha sadar dan terencana untuk mengembangkan potensi yang dimilikinya agar menjadi manusia yang terampil, cerdas,berakhlak, dan dapat mempergunakan bakatnya bagi diri sendiri, masyarakat, bangsa, dan negara. Penelitian ini bertujuan untuk mengidentifikasi pendidikan islam dalam membentuk karakter manusia dan beradab.
Metode yang digunakan dalam penelitian ini adalah metode kualitatif yang menghasilkan data deskriptif berupa kata-kata tertulis atau lisan dari orang-orang yang dapat diamati. Sumber data pada penelitian ini adalah data primer dan data sekunder. Penelitian ini merupakan penelitian kualitatif dengan pendekatan Historis-Fiosofis yang bertujuan untuk mengidentifikasi pendidikan islam dalam membentuk karakter manusia dan beradab.
Dari hasil penelitian diperoleh kesimpulan bahwa, Menurut Adian Husaini dalam membentuk karakter manusia dan beradab yakni pendidikan karakter yang diberikan kepada peserta didik Muslim (khususnya), haruslah pendidikan karakter yang berbasis pada Tauhid dan ta’dib. Hal inilah nantinya yang akan membedakan antara karakter yang dimiliki oleh bangsa lain, dengan karakter yang dimiliki oleh bangsa Indonesia, khususnya pada masyarakat Muslim.
PERANCANGAN APLIKASI POINT OF SALE UNTUK MANAJEMEN PEMESANAN BAHAN PANGAN BERBASIS FRAMEWORK LARAVEL
Authors: Yuniarti Rima , Hartami Santi Indyah , Dwi Puspitasari Wahyu 
Published: May 2022

Dengan berkembangnya teknologi sekarang ini sistem jual beli online sudah mulai menjadi transaksi yang sudah banyak diminati oleh masyarakat. Sistem jual beli online sangat membantu orang-orang yang tidak mau repot dengan masalah tawar-menawar atau harus datang ke tempat perbelanjaan. Untuk menunjang sistem jual beli online dengan baik maka diperlukan sistem point of sale yang dapat membantu manajemen toko lebih mudah lagi. Sumber data penelitian ini diperoleh dari observasi dan wawancara langsung dari pemilik toko sumber berkah. Sistem point of sale sendiri digunakan untuk mempermudah manajemen transaksi jual beli yang disesuaikan dengan kebutuhan pengelola dan harus mudah digunakan oleh pemilik toko yang masih awam terhadap teknologi, sistem ini akan dikembangkan menggunakan pemrograman web berbasis framework laravel. Untuk metode pengembangan sistem menggunakan metode scrum. Hasil dari penelitian ini adalah sistem sistem point of sale yang dapat membantu karyawan toko untuk mengelola transaksi penjualan, riwayat transaksi, persediaan barang, informasi tanggal kadaluarsa barang, laporan keuangan, dan catatan pemesanan barang. Dari hasil pengujian mendapatkan hasil bahwa sistem dapat berjalan dengan baik.
APLIKASI PREDIKSI STOK POPOK BAYI BERBASIS WEB DENGAN METODE TREND MOMENT
Authors: Budiana Hernik Diah , Lestanti Sri , Nur Budiman Saiful 
Published: May 2022

Toko Swalayan Sinar Makmur selama ini dalam menentukan jumlah barang yang akan dipesan ke distributor masih mengandalkan intuisi dan pengalaman kerja karyawan, maka harus ada aplikasi yang dapat melakukan prediksi stok barang. Metode yang dapat membantu pemilik usaha dalam mengelola stok barang di toko adalah metode forecasting atau prediksi menggunakan algoritma Trend Moment. Penelitian ini termasuk penelitian pengembangan menggunakan Trend Moment sebagai algoritma pengembangan aplikasi. Hasil pengujian Black Box menyatakan bahwa kebutuhan fungsional aplikasi yang dibuat dapat berfungsi dengan baik dengan hasil kesesuaian aplikasi sebesar 95,83% dan tingkat kenormalan 89,17% sementara itu hasil pengujian MAPE untuk popok bayi dengan tipe S40, M36, L32, XL28 dan XXL24 berturut-turut adalah 0,258%, 0,495%, 0,385%, 0,175% dan 0,321%.
RANCANG BANGUN OTOMATISASI PEKARANGAN PANGAN LESTARI (P2L) BERBABIS INTERNET OF THINGS
Authors: Firmansyah Firmansyah , Mahmudi Ali , Panji Sasmito Agung 
Published: May 2022

Pekarangan pangan lestari adalah aktivitas yang dilakukan oleh kelompok yang saling mengembangkan pembibitan rumah sebagai sumber makanan yang masuk akal untuk membangun aksesibilitas, ketersediaan, dan penggunaan, serta penghasilan. Namun demikian cara penanganan dan pemeliharaan lahan hortikultura secara fisik masih belum dilakukan yang akan mempengaruhi perkembangan tanaman. Oleh karena itu, penelitian ini bertujuan untuk memudahkan petani untuk melakukan monitoring pekarangan pangan lestari. Dengan adanya permasalahan tersebut, peneliti menggagas sebuah alat yang dapat memonitoring pekarangan berbasis internet of things agar memudahkan pekerjaan petani, agar hasil tanaman pada pekarangan berkualitas dan meminimalisir kegagalan panen. Alat ini berbasis internet of things yang memiliki fitur monitoring suhu, kelembapan udara dan kelembapan tanah secara otomatis, fitur setup pada setiap sensor yang digunakan dan timer untuk mengaktifkan solenoid valve secara otomatis. alat ini dikontrol menggunakan aplikasi android yang mengirim data lewat firebase ke nodeMcu. Hasil pengujian menunjukkan bahwa sensor diketahui memiliki ratarata persentase error pada sensor dht11, suhu 0.67% dan kelembapan 0,43% dan sensor soil moisture 4.29% serta dari hasil pengujian blackbox menunjukkan bahwa aplikasi tidak menemukan kesalahan fungsi pada program. Aplikasi android minimal menggunakan versi android 7.0 (Nougat).
ANALISIS QUALITY OF SERVICE SISTEM MANAJEMEN BANDWIDTH PADA JARINGAN LABORATORIUM TEKNIK INFORMATIKA ITN MALANG
Authors: Pratama Rafif , Dedy Irawan Joseph , Orisa Mira 
Published: May 2022

Kecepatan internet memiliki dua hal yaitu kecepatan upload dan download, dua hal tersebut merupakan faktor penting dalam mengakses data dan informasi. Terdapat banyak hal yang bisa mempengaruhi kecepatan kedua hal tersebut, diantaranya yaitu kapasitas bandwidth yang digunakan dan tingkat kefektifan bandwidth tersebut bisa dimanfaatkan. Tanpa adanya pengaturan manajamen bandwidth disebuah jaringan, membuat banyak pengguna yang menggunakan bandwidth secara tidak beraturan menyebabkan pengguna lain tidak mendapatkan kecepatan akses internet secara adil dan membuat pengguna internet merasa tidak puas dengan pelayanan yang diberikan. Oleh karena itu, diperlukan manajemen bandwidth agar bisa meningkatkan QoS pada jaringan internet tersebut. Dalam pembuatan aplikasi manajemen bandwidth berbasis web menggunakan metode Simple Queue ini, aplikasi dapat melakukan manajemen bandwidth dengan menggunakan parameter Ip Address dari client dan batas kecepatan upload dan download dari client tersebut, melihat banyaknya client yang terkoneksi kedalam jaringan. Hasil aplikasi web manajemen bandwidth ini berupa web yang dapat melakukan manajemen bandwidth client yang terkoneksi dalam jaringan sesuai standar dalam meningkatkan Quality of Service dalam jaringan yang dibangun. Pada hasil pengujian QoS didapatkan bahwa pada sebelum dan sesudah dilakukan manajemen bandwidth dengan parameter pengujian yaitu kefektifan penggunaan bandwidth, dengan nilai rata-rata persentase <37% dibandingkan pada setelah dilakukan manajemen yaitu sebesar 60% hingga 99% pada pada seluruh client. Kemudian pada pengujian packet loss memiliki kategori sedang hingga buruk dengan nilai persentase >13% sedangkan setelah dilakukan manajemen bandwidth mendapatkan nilai persentase <7%. Pada pengujian delay memiliki nilai <150ms dengan kategori sangat bagus pada kedua skenario. Kemudian pada pengujian jitter memiliki hasil pengujian <75ms dengan kategori bagus pada kedua skenario.
PENERAPAN ALGORITMA K-MEANS UNTUK MENENTUKAN STATUS GIZI BALITA (STUDI KASUS: PUSKESMAS KECAMATAN JAWA MARAJA BAH JAMBI)
Authors: Syaputri Vera , Hartama Dedy , Anggraini Fitri , Safii M. , Dewi Rafiqa 
Published: May 2022

Gizi pada anak balita merupakan masalah yang sangat penting untuk diperhatikan terutama bagi orang tua dan tenaga kesehatan. Penelitian ini menggunakan teknik data mining yaitu algoritna K-Means untuk mengclustering gizi balita dengan menggunakan 3 cluster yaitu gizi baik, gizi buruk, dan obesitas. Variabel yang digunakan adalah berat badan dan tinggi badan balita. Berdasarkan hasil dari 60 data, jumlah balita yang mengalami status gizi baik pada puskesmas kecamatan jawa maraja pada cluster 0 terdapat 28 balita, pada cluster 1 terdapat 27 balita yang mengalami gizi buruk , dan terdapat 5 balita yang mengalami obesitas pada cluster 2. Diharapkan hasil penelitian ini dapat memberi masukan pada pihak puskesmas agar lebih memperhatikan asupan gizi pada balita sehingga dapat meningkatkan pertumbuhan dan perkembangan balita.