bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors
Authors: Sreekantan Abhirami P. , Rajan Pooja P. , Mini Minsa , Kumar Praveen 
Published: July 2022

Abstract
Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The most prominent are the efflux pumps (EPs). EPs play a significant role in intrinsic and acquired bacterial resistance, mainly in Gram-negative bacteria. EPs may be unique to one substrate or transport several structurally different compounds (including multi-class antibiotics). These pumps are generally associated with multiple drug resistance (MDR). EPs are energized by a proton motive force and can pump a vast range of detergents, drugs, antibiotics and also β-lactams, which are impermeable to the cytoplasmic membrane. There are five leading efflux transporter families in the prokaryotic kingdom: MF (Major Facilitator), MATE (Multidrug And Toxic Efflux), RND (Resistance-Nodulation-Division), SMR (Small Multidrug Resistance) and ABC (ATP Binding Cassette). Apart from the ABC family, which utilizes ATP hydrolysis to drive the export of substrates, all other systems use the proton motive force as an energy source. Some molecules known as Efflux Pump Inhibitors (EPI) can inhibit EPs in Gram-positive and Gram-negative bacteria. EPIs can interfere with the efflux of antimicrobial agents, leading to an increase in the concentration of antibiotics inside the bacterium, thus killing it. Therefore, identifying new EPIs appears to be a promising strategy for countering antimicrobial drug resistance (AMR). This mini-review focuses on the major efflux transporters of the bacteria and the progress in identifying Efflux Pump Inhibitors.
Malaysia Sebagai Negara Tujuan Human Trafficking Dari Indonesia Studi Kasus: Provinsi Nusa Tenggara Timur
Authors: Darung Servasius , Prasetya Muh. Novan 
Published: July 2022

Almost every province in Indonesia has cases of Human Trafficking, including the Province of East Nusa Tenggara. In 2017, East Nusa Tenggara Province became the area of ​​the highest Human Trafficking case in Indonesia. This is motivated by factors of poverty, lack of employment opportunities, culture, social class differences and globalization. Some of these factors attracted the author's attention to conduct research on Human Trafficking in East Nusa Tenggara and Malaysia as destination countries. In this study, the author uses modernism theory and Marxism theory as critical theory, which is analyzed based on qualitative research methods and uses the Lingko system as a problem solving method in preventing the recruitment process of Human Trafficking in East Nusa Tenggara. The Lingko system is a land division system in Manggarai. However, prevention through the Lingko System also requires an effective role from the government and the people of East Nusa Tenggara in improving the quality of education, serious law enforcement, eliminating social class differences and providing employment opportunities for the people of East Nusa Tenggara.
Keywords: Human Trafficking, Lingko System, East Nusa Tenggara, Indonesia and Malaysia
KERJASAMA INDONESIA-THAILAND DALAM PEMBERANTASAN NARKOBA MENUJU DRUG-FREE ASEAN 2015
Authors: Astuti Wiwiek Rukmi Dwi , Tabitha Sarah , Situmeang Nurmasari 
Published: July 2022

Masalah narkoba yang menjadi masalah dari tahun ke tahun semakin kompleks dan menjadikan masalah narkoba sebagai masalah transnasional yang untuk memberantasnya memerlukan kerjasama dari berbagai lapisan internasional dan nasional. ASEAN sebagai organisasi Asia Tenggara mewujudkan salah satu cita-cita organisasi yaitu kawasan Asia Tenggara yang bebas narkoba melalui Deklarasi ASEAN Bebas Narkoba 2015 berkomitmen untuk memperkuat kerjasama dalam mengatasi penyalahgunaan narkoba dengan rencana kerja yang dirancang bersama. Dalam pelaksanaannya, Indonesia dan Thailand menjalin kerjasama dengan harapan pemberantasan narkoba di kedua negara tersebut, karena seperti kita ketahui bahwa masalah narkoba tidak bisa dilakukan sendiri-sendiri. Dalam kerja sama tersebut, Indonesia dan Thailand melakukan beberapa kegiatan yang dinilai cukup efektif untuk membantu mengatasi masalah krusial tersebut.
Metode penelitian ini adalah kualitatif dengan menggunakan teori Regionalisme dan Kerjasama Internasional dalam analisisnya yang menghasilkan kesimpulan bahwa Kerjasama Indonesia-Thailand terlepas dari kondisi permasalahan narkoba yang masif saat ini, Kerjasama Indonesia-Thailand sedang berjalan. efektif dengan sikap kedua negara yang kooperatif dan berbagai kegiatan yang sedang berlangsung. sesuai dengan cita-cita kedua negara.
Earlier appearance of Risser sign on ultrasound versus radiograph in adolescent idiopathic scoliosis
Authors: Hongo Michio , Kasukawa Yuji , Misawa Akiko , Kudo Daisuke , Kimura Ryota , Miyakoshi Naohisa 
Published: July 2022

Objective
The usefulness of ultrasound in the detailed assessment of the Risser sign is still unclear. The purpose of this study was to analyze the usefulness of ultrasound for determining the Risser sign compared with that determined by conventional radiography by each Risser grade.

Materials and Methods
Eighty-eight iliac crests from 44 adolescent patients who visited the scoliosis clinic with Risser grades 0-4 were evaluated. The ultrasound probe was placed vertically on the iliac crest and the point where iliac apophysis ossification ended was marked. The length of ossification relative to the length of the iliac crest was calculated.

Results
Agreement between radiographic and ultrasound images were found in 58/86 iliac crests (67%). Kappa value was 0.565. Agreement between the two methods with regard to Risser grade was 53% for grade 0, 43% for grade 1, 47% for grade 2, 88% for grade 3, and 90% for grade 4. With additional analysis by integrating grades into two groups, the agreement rate was 47.7% and the Kappa value was 0.288 in the grade 0-2 group, and 88% and 0.703 in grades 3-4 group, respectively. In cases of disagreements, 93% of the iliac crests were judged as having higher Risser grades by ultrasound than by radiograph.

Conclusion
Risser sign evaluation by ultrasound demonstrated a higher agreement rate in grades 3 and 4, whereas less agreement was found in grades 0-2. In the majority of cases with disagreement, ultrasound showed a higher grade than radiography, suggesting that ossification can be detected earlier with ultrasound than with radiography.
HERNIORRHAPHY AND SURGICAL OUTCOMES OF DIAPHRAGMATIC HERNIA IN CATS
Authors: Deveci Mehmet Zeki Yılmaz , Yurtal Ziya , İşler Cafer Tayer , Emiroğlu Sara Büşra , Alakuş İbrahim , Altuğ Muhammed Enes 
Published: July 2022

Abstract: The aim of this study was to evaluate the surgical outcome and mortality of diaphragmatic hernia in cats and present herniorrhaphy results. Diagnostic and surgical data from 25 cats with diaphragmatic hernias were analyzed retrospectively. The cats were between the ages of 2 months and 4 years, included 9 cases of males (5/9 neutered) and 16 cases of females (9/16 spayed). acute cases were 12/25 and chronic cases were 13/25. Diaphragmatic rupture locations were defined according to the points that are determined based on a clockwise scale. Location was classified as multiple in 10 (40 %), ventral in 7 (28 %), right in 5 (20 %), and left in 3 (12 %) cases. The three most frequently herniated organs were small intestine (20, 80 %), liver (16, 64 %), and omentum (15, 60 %). Postoperative survival rates were 83.3 % for acute cases and 69.2 % for chronic. Full recovery was achieved in 19 (76 %) of the cats. Results suggest that the location and size of diaphragm ruptures, the organs herniated, and the presence of concurrent pathologies directly affect mortality. Mortality is higher in cases with concurrent injuries, large diaphragmatic ruptures, and excessively herniated organs.Key words: prognosis; feline diseases; hernia; rupture; survivalHERNIORAFIJA IN KIRURŠKI IZIDI DIAFRAGMALNE KILE PRI MAČKAHIzvleček: Namen te študije je bil ovrednotiti kirurški izid in smrtnost diafragmalne kile pri mačkah ter predstaviti rezultate herniorafije. Retrospektivno smo analizirali diagnostične in kirurške podatke pri 25 mačkah z diafragmalno kilo. Mačke so bile stare od 2 mesecev do 4 let, med njimi je bilo 9 samcev (5/9 kastriranih) in 16 samic (9/16 steriliziranih). Akutnih primerov je bilo 12/25 in kroničnih 13/25. Mesta pretrganja diafragme so bila opredeljena glede na točke, določene na podlagi lestvice v smeri urinega kazalca. Pretrganje je bilo določeno kot večmestno v 10 (40 %) primerih, ventralno v 7 (28 %), desno v 5 (20 %) in levo v 3 (12 %) primerih. Trije najpogosteje vrinjeni organi so bili tanko črevo (20, 80 %), jetra (16, 64 %) in omentum (15, 60 %). Preživetje po operaciji je bilo pri akutnih primerih 83,3 %, pri kroničnih pa 69,2 %. Popolno okrevanje je bilo doseženo pri 19 (76 %) mačkah. Rezultati kažejo, da na umrljivost neposredno vplivajo mesto in velikost raztrganine diafragme, vrinjeni organi in prisotnost sočasnih patologij. Smrtnost je večja pri sočasnih poškodbah, velikih raztrganinah diafragme in prekomernem vrinjenju organov.Ključne besede: prognoza; bolezni mačk; kila; raztrganina; preživetje
The Effectiveness of Teaching Reading to Civil Engineering Students in National Institute of Technology Malang Using Two Strategies
Authors: Rahayu Puji , Heriyawati Dwi Fita 
Published: July 2022

Reading comprehension is important in learning but it is very difficult to define and to achieve. The purpose of this study was to try both approaches (inductive and deductive) to teach reading in order to determine which one is more effective for Civil Engineering students of ITN Malang. This study is conducted in Civil Engineering Department of National Institute of Technology, Malang. Two classes participated in this study. There are 15 students in each class. All of them are freshmen. One class learned reading deductively, and the other learned inductively. To assess the students’ improvement, a series of two test papers were used. From the tests given, it can be found that teaching reading inductively and deductively has equal effectiveness. However, the students taught using the deductive approach performed better in certain questions.
Keywords: Reading , Inductive and Deductive Approach
Risks, Experience, Ease of Purchase Terhadap Purchase Intention Makanan Sehat dengan Moderator Fear Of COVID-19
Authors: Said Raihan Muslim Fajri , Citra Kusuma Dewi  
Published: July 2022

This research is motivated by the COVID-19 pandemic, that has made Indonesians pay more attention to their health so they don't get infected with the virus. Efforts are made by consuming healthy foods. The increasing consumption of healthy food causes various kinds of problems ranging from risks that consumers must bear, unpleasant shopping experiences, to obstacles for consumers when obtaining healthy food. The purpose of this study was to examine the effect of Overall risk, Purchase experience, and Ease of purchase on Purchase intention, as well as examine how high the Moderation of Fear of COVID-19 is on the relationship between Ease of purchase and Purchase intention of Healthy Food.
This type of research is included in quantitative and causal. The analysis used is descriptive analysis usingStructural Equation Model-Partial Least Square (SEM-PLS). Technique. The sampling used is non-probability sampling with purposive sampling type. Then the number of samples in this study were 385 respondents in the Jabodetabek and Bandung City communities who had consumed healthy food.
The results of this research using SEM-PLS are all independent variables consisting of Overall risk, Purchase experience, and Ease of purchase have a positive and significant influence on the dependent variable, namely Purchase intention. In addition, the moderator of the Fear of COVID-19 study did not moderate the relationship between Ease of purchase and Purchase intention. Keywords : Overall risk, Purchase experience, Ease of purchase, Purchase intention, Fear of COVID-19
Keyword: Risk; Experience; Ease; Intention; COVID-19
Audiovisual Demonstration Methods on The Knowledge and Behavior of Cadres About Stimulation of Massage Therapy in Improving Nutrition Status in Children
Authors: Fazrin Intan , Anggraeni Suci , Saputro Heri 
Published: July 2022

This study uses a pre-experimental one group pre-post test design. The population in this study were all cadres of Posyandu under five in the working area of ​​the Pesantren II Public Health Center, Pakunden Village, Kediri City, which amounted to 47 people. The number of respondents as many as 38 people were selected randomly using simple random sampling. Data analysis used paired t test. The results of the study showed that the mean value of knowledge before was 6.37 and after 7.42. The mean value for behavior before is 19.24 and after 19.79, so it can be concluded that there is an increase in knowledge and behavior of cadres. There was an effect of giving the audiovisual demonstration method on the knowledge of cadres about massage therapy stimulation in improving nutritional status in children (Sig. 0.003 <0.05) and cadres' behavior about massage therapy stimulation (Sig. 0.004 <0.05)
Effectiveness Of Loving Massage To Treat Back Pain In Pregnant Women In Third Trimester
Authors: Mardiyanti Ika , Andriani Ratna Ariesta Dwi , Amalia Rizki 
Published: July 2022

This study used an analytic design with a cross sectional design with a Quasi Experiment approach to Non Equivalent Control Group Design. Samples were taken using a total sampling of 30 pregnant women, 15 received intervention and 15 controls. Data analysis using Mc Nemar and Mann Withney statistical test. The results showed that (66.7%) of respondents were of low risk age (20-35 years), (83.3%), (70%) of low risk parity (children <5). Statistical analysis with Mc Nemar obtained = 0.01 < = 0.05 meaning that there is an effect of loving massage on back pain, and from the results of Mann Withney obtained = 0.007 <α = 0.05 meaning that there is a difference between the intervention group and the control group . The conclusion is that there is an effect of giving loving massage to back pain in third trimester pregnant women
Evaluation Of The Implementation Of The 2020 Basic Life Support Guideline In Evacuation Of Natural Disaster Victims At The Forum Volunteer Sidoarjo Tough (Forest)
Authors: Winoto Priyo Mukti Pribadi , Setiawan Arif Helmi , Rohmawati Riska 
Published: July 2022

This study aims to evaluate the application of the 2020 basic life support guidelines in the evacuation of victims of natural disasters by the Sidoarjo Tangguh Volunteer Forum (Forest). This research method uses a quantitative cross-sectional design that aims to photograph and analyze the situation at a certain time to evaluate the application of the 2020 basic life support guidelines in the evacuation of victims of natural disasters. The sample in this study was taken with a total sampling of 20 people. Methods of collecting data using primary data, through questionnaires and using a check list. Data processing was carried out by means of Wilcoxon sign rank test analysis. Basic Life Support can run well if all elements are carried out thoroughly, therefore it is necessary to have clear roles, duties and responsibilities from the management to support the success in evacuating victims of natural disasters at the Volunteer Forum
The Effect Of Progressive Mobilization On The Event Of Decubitus In Patients With Mechanical Ventilation In Icu Room Of Mangusada Hospital
Authors: Prihandhani IGAA Sherlyna , Gandari Ni Komang Matalia , Pradiptha I Dewa Agung Gde Fanji , Hakim Nina Rismawati 
Published: July 2022

This study aimed at identifying the effect of progressive mobilization on pressure ulcer incidents in patient with mechanical ventilation in the Intensive Care Unit at Mangusada Hospital. The design of this study was PreExperiment (one group pretest and posttest design). The instrument used in this study was a standard procedure of Richmond Agitation Sedation Scale (RASS) and observation sheet of Decubitus. The result of the test indicated most of the respondents experienced grade I pressure ulcer (decubitus) before being given progressive mobilization therapy and after the therapy, all respondents (100%) did not show pressure ulcer (decubitus) incident. Wilcoxon test showed that there was an effect of progressive mobilization on pressure ulcer incidents in patient with mechanical ventilation in the Intensive Care Unit at Mangusada Hospital (p-value = 0,042).
The Effect of Hypnosis Breastfeeding (Hypnobreastfeeding) on Breastfeeding Self Efficacy in Postpartum Mothers at Kediri City
Authors: Rohmah Miftakhur , Wahyuni Candra , Mufida Riza Tsalatsatul 
Published: July 2022

The research design used was a quasy experiment with a nonequivalent control group design approach involving 40 postpartum mothers as respondents consisting of 20 treatment groups and 20 control groups, which were taken by purposive sampling. The statistical test used in this study is the Mann Whitney test. The results showed that the rest-feeding self-efficacy in the control group was mostly in the category of less than 80% (16 people), and in the treatment group mostly in the good category of 85% (17 people). The results of statistical tests using Mann Whitney obtained p-value (0.00 <0.05), which means that there is an effect of giving breastfeeding hypnosis (hypnobreastfeeding) on breastfeeding self-efficacy in postpartum mothers. Planting positive affirmations through hypnobreastfeeding into one's subconscious mind, can increase the mother's confidence in breastfeeding so that breastfeeding can be optimal for babies and achieve exclusive breastfeeding
The Relationship Between Leadership Style and Work Motivation with Burnout Syndrome in Nurses during the Covid 19 Pandemic
Authors: Soliha Soliha , Reza Rahmad Septian 
Published: July 2022

The high number of patients, inadequate hospital facilities, and the high risk of exposure to diseases during the covid 19 pandemic make nurses experience Burnout syndrome. This research is a correlational analysis with a cross sectional approach. A population of 60 respondents with simple random sampling techniques. Independent variables are leadership styles and work motivation, while variable dependencies are burnout syndrome in nurses. Instrument research using the Maslach Burnout Syndrome Inventory (MBI) questionnaire. Analysts test used Kendall's tau_b and Spearman Rank test with @=0.05. The results showed that 55% of respondents aged 31-40 years, 90% of marital status, 55% of female sex, 53,3% of Ners education level and 56.6% length of work more than 10 years. Statistics test showed there was a relationship between leadership style and burnout syndrome in nurses with test results (p=0.047 < @=0.05).
Systematics Literature Review: Pengembangan Mathematical Proficiency dalam Pembelajaran Matematika
Authors: Herlina Sari , Juandi Dadang 
Published: July 2022

National Research Council mengembangkan konsep Mathematical Proficiency dalam lima strands yaitu: Conceptual Understanding, Procedural Fluency, Strategics competence, Adaptive Reasoning, and Productive Disposition. Tujuan dari studi ini untuk menganalis pengembangan mathematics proficiency dalam pembelajaran matematika. Metode dalam penelitian ini adalah Systematic Literature Review (SLR). Adapun tahapan SLR dalam penelitian ini, yaitu: 1) Mengembangkan pertanyaan penelitian; 2) Mendesain kerangka konseptual; 3) Membuat kriteria seleksi; 4) Mengembangkan strategi sencarian; 5) Menseleksi kajian berdasarkan kriteria seleksi; 6) Mengkode kajian; 7) Menentukan kualitas kajian; 8) Mensintensis hasil kajian; 9) Melaporkaan temuan. Dalam penelitian ini menggunakan 10 artikel yang paling relevan dari 102 artikel yang ditemukan menggunakan aplikasi publish and perish. Artikel-artikel yang dikaji merupakan artikel-artikel dari jurnal internasional yang terindeks scopus. Artikel diambil dari tahun 2010 sampai 2022. Kemampuan mathematical proficiency dapat dikembangkan dengan bantuan guru/pendidik melalui beberapa cara, antara lain: 1) memilih strategi pembelajaran yang tepat sesuai karakteristik peserta didik; 2) mempersiapkan perangkat pembelajaran; 3) menyiapkan soal-soal yang dapat mengembangkan proses berpikir matematis sehingga mengembangkan kecakapan matematis siswa ; 4) meningkatkan kompetensi seorang guru melalui seminar, pelatihan dan lainnya; 5) memberikan tantangan bagi siswa dalam belajar matematika.
Pengembangan E-modul Matematika pada Materi Barisan dan Deret Berbantuan Smart App Creator untuk Siswa SMA/SMK
Authors: Alpiani Nova , Pamungkas Aan Subhan , Jaenudin Jaenudin 
Published: July 2022

Perkembangan teknologi telah menuntut guru untuk lebih berinovasi dalam proses pembelajaran. Dengan itu perlu adanya media pembelajaran yang tidak terbatas untuk dipelajari disekolah yaitu berupa E-modul pembelajaran agar siswa dapat belajar kapan saja dan dimana saja. Untuk itu peneliti akan mengembangkan aplikasi pembelajaran materi barisan dan deret kelas XI SMA/SMK. Jenis penelitian yang digunakan yaitu R&D dengan model ADDIE (Analyze, Design, Develovment, Implementation, dan Evaluation). Adapun subjek dalam penelitian ini yaitu 25 siswa SMK Nurul Huda. Instrumen yang digunakan yaitu penyebaran angket dan tes evaluasi berupa soal uraian. Hasil yang diperoleh dari ahli materi 90,95% dan ahli media 90,28% dari kedua ahli tersebut diperoleh kategori sangat valid. Kemudian, hasil keperaktisan setelah menggunakan E-Modul menurut respon siswa diperoleh 84,82% dengan kategori sangat baik dan tes hasil belajar yang dilakukan oleh 25 siswa memperoleh nilai rata-rata 77,4 dengan kategori baik dan persentase klasikal 76%. Sehingga E-Modul pembelajaran dengan berbantuan Smart App Creator yang menghasilkan aplikasi android layak, praktis, dan efektif digunakan pada proses pembelajaran di SMA/SMK.
Pragmatic Meaning-based within the Encyclopedic Meaning Frame
Authors: Abdulghany Suzan Saadulla , Wali Hazhar Hussein 
Published: July 2022

لا تقتصر عناصر اللغة على الملفوظات المكونة للتراكيب اللغوية الاكبر حجما، ولا على قوالب مجسدة لمعاني محددة وجامدة حصراً، بل إنها تحتوى في احشائها على نوعية التفكير، المشاعر، الاحاسييس، التجارب و الرؤى المختلفة للانسان، وكذلك العادات و التقاليد الاجتماعية...الخ. يحتاج الوصول الى تلك الابعاد المختلفة تبني تفسير مختلف و غير تقليدي للمعنى على ان اللغة و المعنى اللغوي/ الحرفي ليست مرتبطة بالكفاية اللغوية وحدها، فهي غير مستقلة بذاتها، بل إنها تعتبر انعكاس الكفاية الادراكية للإنسان. ينظر علم اللغة الادراكي ضمن اطار علم الدلالة الادراكي الى المعنى من هذا المنظور، إذ إنه يرى ان للمعني طبيعة موسوعية التي تكمن فيها جميع انواع المعنى المصنفة من قبل المدارس الاخرى, ومن هنا يذهب علم اللغة الادراكيي الى عدم التفرقة بين المعنى الدلالي و المعني التداولي /البراكماتيكي. من هذا المنطلق، تحاول هذه الدراسة المعنونة "ارتكازية المعنى التداولي في اطار المعنى الموسوعي" تفسير المعنى التداولى من منظور المعنى الموسوعي في اطار علم اللغة الادراكية.

پوختە
یەکەکانى زمان تەنها دەربڕاوێک نین بۆ دروستکردنى پێکهاتەیەکى گەورەتر لە خۆیان و قاڵبێک بن هەڵگرى واتایەکى بەرجەستەى دیاریکراو بن، بەڵکو لە ناواخنیاندا جۆرى بیرکردنەوەو هەست و سۆزو ئەزموون و دونیابینى مرۆڤەکان و دابونەریتە کلتورى و کۆمەڵایەتییەکان و ... تاد هەڵگیراون. پەیپێبردن بەم لایەنە جیاوازانەش پێویستى بەوە هەیە، کە لێکدانەوەیەکى جیاواز لە لێکدانەوە چاولێکەرییەکان بۆ واتا بکرێت، بەوەى کە زمان و واتاى زمانى ڕەنگدانەوەى توانا درکپێکراوە گشتییەکانى مرۆڤە، نەک تەنها ئەو توانایانەى، کە تایبەتن بە زمان. زانستى زمانى درکپێکردن لە چێوەى سیمانتیکى درکپێکردندا لەم ڕوانگەیەوە لە واتا دەڕوانێت و پێیوایە واتا سروشتێکى ئینسکلۆپیدیایى هەیە، لە نێو ئەو سروشتە ئینسکلۆپیدیایەیشدا هەموو ئەو چەشنانەى واتا، کە لە قوتابخانەکانى پێشتردا جیاکرابوونەوە، بوونیان هەیە. هەر لێرەشەوەیە زانستى زمانى درکپێکردن واتاى سیمانتیکى و واتاى پراگماتیکى لە یەکتر جیاناکاتەوە.