bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of magnetic resonance imaging in the preoperative diagnosis of tibial plateau fractures: a systematic literature review
Authors: Thürig Gregoire , Korthaus Alexander , Frosch Karl-Heinz , Krause Matthias 
Published: October 2022

Abstract
Purpose
The outcome of a tibial plateau fracture (TPF) depends on the fracture reduction achieved and the extent of soft-tissue lesions, including lesions in the ligaments, cartilage, and menisci. Sub-optimal treatment can result in poor knee function and osteoarthritis. Preoperative planning is primarily based on conventional X-ray and computed tomography (CT), which are unsuitable for diagnosing soft-tissue lesions. Magnetic resonance imaging (MRI) is not routinely performed. To date, no literature exists that clearly states the indications for preoperative MRI. This systematic review aimed to determine the frequency of soft-tissue lesions in TPFs, the association between fracture type and soft-tissue lesions, and the types of cases for which MRI is indicated.

Methods
A systematic review of the literature was based on articles located in PubMed/MEDLINE and the Cochrane Central Register of Controlled Trials (CENTRAL), supplemented by searching the included articles’ reference lists and the ePublication lists of leading orthopedic and trauma journals.

Results
A total of 1138 studies were retrieved. Of these, 18 met the eligibility criteria and included a total of 877 patients. The proportion of total soft-tissue lesions was 93.0%. The proportions of soft-tissue lesions were as follows: medial collateral ligament 20.7%, lateral collateral ligament 22.9%, anterior cruciate ligament 36.8%, posterior cruciate ligament 14.8%, lateral meniscus 48.9%, and medial meniscus 24.5%. A weak association was found between increasing frequency of LCL and ACL lesions and an increase in fracture type according to Schatzker's classification. No standard algorithm for MRI scans of TPFs was found.

Conclusion
At least one ligament or meniscal lesion is present in 93.0% of TPF cases. More studies with higher levels of evidence are needed to find out in which particular cases MRI adds value. However, MRI is recommended, at least in young patients and cases of high-energy trauma.
Is intra-articular injection of autologous micro-fragmented adipose tissue effective in hip osteoarthritis? A three year follow-up
Authors: Natali Simone , Screpis Daniele , Romeo Michele , Magnanelli Stefano , Rovere Giuseppe , Andrea Amarossi , Camarda Lawrence , Zorzi Claudio 
Published: October 2022

Abstract
Background
Recently, increased attention on regenerative medicine and biological injective treatments have been proposed to restore native cartilage. Micro-fragmented adipose tissue (MFAT) has been studied for its anti-inflammatory, paracrine, and immunomodulatory effects. The long-term effects of MFAT are still poorly understood: the aim of the present study is to demonstrate how hip articular injections with autologous MFAT can have an impact on clinical outcomes.

Methods
Seventy-one consecutive patients affected by early hip osteoarthritis underwent an ultrasound-guided hip injection of autologous MFAT between June 2017 and December 2018. Patients were divided into four groups according to the Oxford Hip Score. All patients received 4 mL of autologous micro-fragmented adipose tissue under an ultrasound guide. A clinical evaluation was done between 29 and 41 months after the initial treatment. During this follow-up period, we recorded any new treatment the patients had done, whether that be injection or arthroplasty surgery.

Results
The study included 55 patients. Out of 55 patients, 28 saw benefits and were in no need of further treatment. Moreover, the score between the beginning and control increased by 6.9 points. Ten patients underwent a new articular injection: the mean time between the two injections was 635.7 ± 180 days. Seventeen patients underwent total hip replacement: the mean period between the autologous MFAT injection and the surgery was 495 days.

Conclusion
This study found that intra-articular injections with autologous MFAT achieve beneficial clinical results in patients affected by early to moderate hip osteoarthritis, with an OHS between 48 and 30. Furthermore, these subjects are the ideal patients for whom this treatment obtains good clinical results.
The Prognostic Value of Nodal Skip Metastasis in Patients with Esophageal Cancer: A Systematic Review and Meta‐Analysis
Authors: Li Xiaokun , Shang Qixin , Yang Yushang , Zhou Jianfeng , Fang Pinhao , Luan Siyuan , Xiao Xin , Yuan Yong 
Published: October 2022

AbstractBackgroundEsophageal cancer (EC) is the sixth leading cause of cancer deaths worldwide. Nodal skip metastasis (NSM), a common form of lymphatic spread in EC, can be defined as the metastatic involvement of distant lymph nodes (LNs) without prior involvement of adjacent LNs. The results of the previous studies investigating the association between NSM and survival outcomes in patients with EC were inconsistent and even contradictory. The aim of this systematic review and meta‐analysis is to investigate the prognostic value of NSM and to summarize the NSM definitions of EC in previous studies.MethodsFour databases were used in this meta‐analysis. The association between NSM and overall survival (OS) was evaluated by using pooled HRs and their 95% confidence interval (CI). The sensitivity analysis and funnel plot were used to assess the publication bias.ResultsNine studies were included in this meta‐analysis. The pooled results of meta‐analysis indicated that there was no significant association between NSM and OS (HR = 0.99, 95% CI: 0.75–1.31; P = 0.951). Meanwhile, according to the results of sub‐group analysis on the basis of histological feature, method of lymphadenectomy, node staging system, and NSM definitions, no significant association was found between NSM and OS.ConclusionsOn the basis of available evidences, NSM could not be used as a prognostic factor for patients with EC. For future studies investigating the prognostic value of NSM, only three‐field lymphadenectomy with adequate harvested LNs can be performed. NSM definitions based on lymph node station and anatomical compartment could both be feasible classification for EC.
Socio-demographic parameters and non-cardiac comorbidity related to self-perceived quality of life in young adults after neonatal arterial switch operation for transposition of the great arteries
Authors: Hövels-Gürich Hedwig H. , Lebherz Corinna , Korte Bettina , Vazquez-Jimenez Jaime F. , Marx Nikolaus , Kerst Gunter , Frick Michael 
Published: October 2022

AbstractEvaluating the relation of non-cardiac comorbidity and socio-demographic factors to physical and mental health-related quality of life (QOL) which has been partially found at elevated risk in young adults after neonatal arterial switch operation (ASO) for transposition of the great arteries (TGA). In a prospective reassessment study, results of 92 unselected young adults (22.8 ± 2.6 years) having undergone evaluation of QOL (SF-36) were related to non-cardiac comorbidity with special respect to neurologic and psychiatric comorbidity and to socio-demographic parameters. Neurologic (14%) contrary to psychiatric comorbidities (6.5%) were more frequent than in the general population. The educational level was higher, the rate of unemployment was double as high compared to the average German population. Significant inverse relations (p = 0.006 to 0.033) existed between physical health domains (physical functioning and general health perception) and non-cardiac, neurologic, and psychiatric comorbidity, as well as correlations between the latter domains and socio-economic status, educational level, and worse employment status (Spearman 0.22–0.41, p < 0.0001 to 0.036). Mental health domains (vitality, social functioning, psychical health) were significantly inversely related with neurologic and psychiatric comorbidity (p = 0.002 to 0.048) and correlated with higher educational level (Spearman 0.25, p = 0.019). Neurologic and psychiatric comorbidities and socio-demographic parameters are significant risk factors for a reduced QOL concerning physical and mental health in young adults with TGA after ASO. Standardized QOL measurement should be part of routine screening programs to detect subclinical physical, neurodevelopmental, and psychosocial comorbidity.
Graphical abstract
Muscle fatigue response of rotator cuff muscles in different postures
Authors: Aranha Lisanne , Eapen Charu , Patel Vivek D. , Prabhakar Ashish J. , Hariharan Karthik 
Published: October 2022

Abstract
Introduction
Muscle fatigue is a leading cause of rotator cuff (RC) pathologies. Scapular orientation affected by changes in the thoracic spine account for differences in body postures leading to altered RC muscle activation. This posture-related alteration in RC muscle activation and its fatigue response needs to be analyzed.

Materials and methods
This study included 50 healthy shoulders with no coexisting spine pathologies. Raw data were recorded using electromyography sensors for RC muscles during two isometric maneuvers of abduction and external rotation, performed at 30% maximum voluntary contraction at 30°, 45°, and 90° arm elevation in sitting and standing. The raw data were analyzed in DataLITE® software, and the mean power frequency (MPF) was extracted to analyze the fatigue response of RC muscles. The Wilcoxon signed-rank test and Kruskal–Wallis test with Bonferroni corrections analyzed fatigue differences between postures and various activities. P < 0.05 was considered significant for the results.

Results
Supraspinatus muscle demonstrated significant fatigue at 90° of arm elevation in standing as compared to sitting (MPF −5.40: −5.41; P = 0.03) posture. Between the three elevation angles, all the RC muscles showed increased fatigue at 90° (MPF range −5.22 to −6.64). When compared between abduction and external rotation, only infraspinatus showed fatigue in external rotation (MPF range −5.42 to −6.08). Among all the three RC muscles, infraspinatus showed the maximum fatigue of MPF −6.64 when compared to supraspinatus −5.22 and teres minor −5.36.

Conclusion
The findings indicate that alterations in the body postures and different elevation angles affect the RC muscles’ fatigue response.
Control of parallelized bioreactors II: probabilistic quantification of carboxylic acid reductase activity for bioprocess optimization
Authors: von den Eichen Nikolas , Osthege Michael , Dölle Michaela , Bromig Lukas , Wiechert Wolfgang , Oldiges Marco , Weuster-Botz Dirk 
Published: October 2022

AbstractAutonomously operated parallelized mL-scale bioreactors are considered the key to reduce bioprocess development cost and time. However, their application is often limited to products with very simple analytics. In this study, we investigated enhanced protein expression conditions of a carboxyl reductase fromNocardia otitidiscaviaruminE. coli. Cells were produced with exponential feeding in a L-scale bioreactor. After the desired cell density for protein expression was reached, the cells were automatically transferred to 48 mL-scale bioreactors operated by a liquid handling station where protein expression studies were conducted. During protein expression, the feed rate and the inducer concentration was varied. At the end of the protein expression phase, the enzymatic activity was estimated by performing automated whole-cell biotransformations in a deep-well-plate. The results were analyzed with hierarchical Bayesian modelling methods to account for the biomass growth during the biotransformation, biomass interference on the subsequent product assay, and to predict absolute and specific enzyme activities at optimal expression conditions. Lower feed rates seemed to be beneficial for high specific and absolute activities. At the optimal investigated expression conditions an activity of$$1153\ U\ mL^{-1}$$1153UmL-1was estimated with a$$90\%$$90%credible interval of$$[992, 1321]\ U\ mL^{-1}$$[992,1321]UmL-1. This is about 40-fold higher than the highest published data for the enzyme under investigation. With the proposed setup, 192 protein expression conditions were studied during four experimental runs with minimal manual workload, showing the reliability and potential of automated and digitalized bioreactor systems.
Genesis and progress of virtual power principle
Authors: Romano Giovanni , Barretta Raffaele , Diaco Marina 
Published: October 2022

AbstractThe virtual power principle (VPP) of continuum mechanics states a celebrated variational equality between external and internal virtual powers for any virtual velocity field conforming with linear kinematic constraints. The topic is here addressed to investigate how the original ideas born in the early XIX century are modelled by modern formulations based on Functional Analysis and Differential Geometry. These notions are able to provide an effective mathematical context for proving existence of Lagrange multipliers associated with the constraint of rigidity on velocity fields. The VPP stands as privileged tool for giving to stress fields a consistent definition based on duality with conforming virtual stretching fields. By complementarity, the VPP generates a variational condition for integrability of stretching fields, with self-equilibrated stresses as test fields. Progress is got by the formulation of the rate virtual power principle (RVPP) by time derivation of the VPP along the motion, with internal virtual power integrated per unit mass. The basic distinction between spatial and material fields according to the geometric paradigm is prompted to replace the one previously adopted in the literature. The need for a non-redundant implicit formulation of the rigidity constraint is emphasised to contrast degeneracy. This logical demand avoids proliferation of multipliers, in the spirit of Ockham’s Razor, a celebrated philosophical motto with multiform applications. The shining mathematical theory set out by Leonhard Euler, Jean-Baptiste Le Rond d’Alembert, Joseph Louis Lagrange, and Augustin Cauchy is in this respect a point of optimality. A geometric rate theory of elasticity meets the call for no-dissipation in push-closed elastic cycles, with non need of any finite strain elastic energy functional, thus leading to a proper statement of rate equilibrium problems, basilar for computational formulations and for investigations about instability phenomena and post-critical behaviours.
Zur Akzeptanz der Begrenzung
Authors: Löffler-Stastka Henriette 
Published: October 2022

ZusammenfassungUnbewusste affektiv-kognitive Phänomene beeinflussen Entscheidungsfindung, Entwicklung von Einstellungen, Problemlösung und Kreativität. In chronischen Belastungssituationen kann durch das Akzeptieren des Nichtwissens die Handlungsfreiheit wiedergefunden werden.
Honey bees find the shortest path: a collective flow-mediated approach
Authors: Nguyen Dieu My T. , Fard Golnar Gharooni , Atkins Ashley , Bontempo Paul , Iuzzolino Michael L. , Peleg Orit 
Published: October 2022

AbstractHoney bees (Apis mellifera L.) are social insects that makes frequent use of volatile pheromone signals to collectively navigate unpredictable and unknown environments. Ants have been shown to effectively use pheromone trails to find the shortest path between two points, the nest and the food source. The ant pheromone trails are accomplished by depositing pheromones which are then diffused passively, creating isotropic (i.e., non-directional and axi-symmetric) signals. In this study, we report the first instance of the honey bees’ ability to solve the shortest path problem to localize the queen and aggregate around her by using a collective flow-mediated scenting strategy. In this strategy, individual bees not only emit pheromones but also fan their wings to actively direct the flow of the signals, providing colony members with directional messages to the queen’s location. We use computer vision and deep learning approaches to perform automatic and accurate image analysis. As a result, we quantify the number of bees in the short and long paths, and show that the short path is frequented by significantly more bees over time. We also reconstruct attractive surfaces using the positions and directions of scenting bees, and show that this surface is more “attractive” along the short path and around the queen as scenting bees send out directional messages and the swarm makes their way to the queen. Overall, we show that honey bees can effectively use the collective scenting behavior to overcome local and volatile pheromone communication and find the shortest path to the queen.
Robust portfolio optimization for banking foundations: a CVaR approach for asset allocation with mandatory constraints
Authors: Arcuri Maria Cristina , Gandolfi Gino , Laurini Fabrizio 
Published: October 2022

AbstractThis paper focuses on an innovative asset allocation strategy for risk averse investors who operate on very long-time horizons, such as endowments and the Italian foundations of banking origin (FBOs). FBOs play a pivotal role in supporting economic, financial and sustainable growth in the long term. In the search for a model which optimizes FBO portfolio choices in the light of regulatory constraints on their sizeable investable portfolio, we highlight the risk-adjusted performances obtained using a robust conditional VaR (R-CVaR) approach—assuming different risk profiles—which corrects some of the Markowitz approach pitfalls and accounts for tail risk. We compare the two models using a buy and hold strategy: the R-CVaR delivers better returns than a Markowitz portfolio, even when those performances are measured with a mean–variance metric.
On enterprise coherence governance with GEA: a 15-year co-evolution of practice and theory
Authors: Proper Henderik A. , Wagter Roel , Bekel Joost 
Published: October 2022

AbstractGeneral Enterprise Architecting (GEA) is an enterprise architecture method which has emerged out of a need in practice, and has been developed and matured over the past 15 years. The GEA method differs from other enterprise architecture approaches in that it has a strong focus on enterprise coherence and the explicit governance thereof. This focus followed from the observed need to move beyond the Business-IT alignment and ‘Business-to-IT’ stack thinking that is embodied in most of the existing enterprise architecture approaches. The main objective of this paper is to report, and reflect on, the development of the GEA method (so-far), which involved a co-evolution between theory and practice. In doing so, we also present core elements of (the current version of) GEA, and illustrate these in terms of a real-world (social housing) case. We will, furthermore, also discuss some of the lessons learned in applying GEA across different organizations.
Impact of body mass index and diabetes on myocardial fat content, interstitial fibrosis and function
Authors: Dong Xin , Strudwick Mark , Wang William YS , Borlaug Barry A. , van der Geest Rob J , Ng Austin CC , Delgado Victoria , Bax Jeroen J. , Ng Arnold CT 
Published: October 2022

Abstract
Purpose
We hypothesize that both increased myocardial steatosis and interstitial fibrosis contributes to subclinical myocardial dysfunction in patients with increased body mass index and diabetes mellitus.

Background
Increased body weight and diabetes mellitus are both individually associated with a higher incidence of heart failure with preserved ejection fraction. However, it is unclear how increased myocardial steatosis and interstitial fibrosis interact to influence myocardial composition and function.

Methods
A total of 100 subjects (27 healthy lean volunteers, 21 healthy but overweight volunteers, and 52 asymptomatic overweight patients with diabetes) were prospectively recruited to measure left ventricular (LV) myocardial steatosis (LV-myoFat) and interstitial fibrosis (by extracellular volume [ECV]) using magnetic resonance imaging, and then used to determine their combined impact on LV global longitudinal strain (GLS) analysis by 2-dimensional (2D) speckle tracking echocardiography on the same day.

Results
On multivariable analysis, both increased body mass index and diabetes were independently associated with increased LV-myoFat. In turn, increased LV-myoFat was independently associated with increased LV ECV. Both increased LV-myoFat and LV ECV were independently associated with impaired 2D LV GLS.

Conclusion
Patients with increased body weight and patients with diabetes display excessive myocardial steatosis, which is related to a greater burden of myocardial interstitial fibrosis. LV myocardial contractile function was determined by both the extent of myocardial steatosis and interstitial fibrosis, and was independent of increasing age. Further study is warranted to determine how weight loss and improved diabetes management can improve myocardial composition and function.
Interrupting the Cycle: Association of Parental Stress and Child/Youth Psychotropic Medication Nonadherence
Authors: Theall Laura , Ninan Ajit , Arbeau Kim , Mannone Jessica , Stewart Shannon L. 
Published: October 2022

AbstractEfficacy of psychotropic medication depends in large part on successful adherence to prescribed regimens. This study investigated child/youth nonadherence in relation to family dynamics and informal support. The participants were 10,225 children and youth prescribed psychotropic medication and receiving services from 50 Ontario mental health agencies, assessed with the interRAI™ Child and Youth Mental Health (ChYMH) and ChYMH-Developmental Disability (ChYMH-DD) tools. Findings suggest a cycle of parental stress and child/youth medication nonadherence possibly leading to or even perpetuated by worsening psychiatric symptoms. Informal supports do not appear to moderate this cycle. While the present data cannot speak to causes of medication nonadherence in children/youth or where the cycle begins, the results are consistent with the extant literature calling for attention to parental wellbeing to support children/youth for optimal therapeutic benefits. Understanding home dynamics related to nonadherence can assist care planning that engages the family to achieve best possible child/youth outcomes.
Heterogeneous sets in dimensionality reduction and ensemble learning
Authors: Reeve Henry W. J. , Kabán Ata , Bootkrajang Jakramate 
Published: October 2022

AbstractWe present a general framework for dealing with set heterogeneity in data and learning problems, which is able to exploit low complexity components. The main ingredients are (i) A definition of complexity for elements of a convex union that takes into account the complexities of their individual composition – this is used to cover the heterogeneous convex union; and (ii) Upper bounds on the complexities of restricted subsets. We demonstrate this approach in two different application areas, highlighting their conceptual connection. (1) In random projection based dimensionality reduction, we obtain improved bounds on the uniform preservation of Euclidean norms and distances when low complexity components are present in the union. (2) In statistical learning, our generalisation bounds justify heterogeneous ensemble learning methods that were incompletely understood before. We exemplify empirical results with boosting type random subspace and random projection ensembles that implement our bounds.