bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic necrosectomy of infected WON in acute necrotising pancreatitis – Development of an effective therapeutic algorithm based on a single-center consecutive patient cohort
Authors: Jaeger Kristin , Meyer Frank , Füldner Frank , Will Uwe 
Published: September 2022

Abstract
Objective Development of an effective therapeutic algorithm for interventional (minimally invasive) approach to infected walled-off necrosis (WON) in patients with necrotising pancreatitis reflecting real-word data.
Material/methods All consecutive patients who underwent endoscopic necrosectomy for necrotising pancreatitis through a defined study period were enclosed in this retrospective observational case study. The therapeutic approach was analysed for clinical success rate, complication spectrum and rate as well as mortality and compared with data from the literature. Finally, a therapeutic algorithm was derived.
Results From 2004 to 2019, 126 patients with necrotising pancreatitis (median of APACHE II score, 10.5 points) were treated. In 92.9 % of cases (n=117), an infected WON with microbial pathogen detection was found. After a median of 18 days from symptom onset, first intervention was performed (53.2 % as percutaneous drainage with programmed rinsing, 29.4 % as EUS-guided internal drainage). From 2004 to 2010, double pigtail stents were used. Later, lumen-apposing metal stent (LAMS) such as AXIOSTM stent (Boston Scientific, Ratingen, Germany) was preferred. The combined percutaneous and internal drainage was performed in approximately 50 % of subjects.Endoscopic transluminal necrosectomy was performed in 123 patients (97.6 %) at a median of 33 days from symptom onset. Endoscopic percutaneous necrosectomy was conducted in 11.1 % of the individuals. A median number of two endoscopic necrosectomy sessions per patient was necessary for the therapy. The clinical success rate (discharge without surgical intervention) was 82.5 %. The complication rate (bleeding and perforation) and the need for surgery were both 9.5 %. The overall mortality was 8.7 %.
Conclusion Therapy of necrotising pancreatitis with infected WON consists of early calculated antibiotic therapy with adequate drainage. Combined external and internal drainages with programmed rinsing seem to improve prognosis, as well as minimise i) the need for forced necrosectomies (mainly via a transluminal access site) and ii) complication rate as well as, thus, improve outcome.
Nationales Kompetenznetzwerk Contergan – Sicherstellung der medizinischen Versorgung von Menschen mit Thalidomid-Embryopathie
Authors: Beyer Rudolf , Peters Klaus M. , Schulte-Hillen Jan , Stück Volker , Niecke Alexander 
Published: September 2022

ZusammenfassungIn Deutschland hat sich 2021 ein nationales Netzwerk von multidisziplinären medizinischen Kompetenzzentren etabliert, das sich der Sicherstellung der Versorgung Contergan-geschädigter Menschen verpflichtet fühlt. Der vorliegende Beitrag möchte auf dieses Kompetenznetzwerk aufmerksam machen und einen Überblick über die wichtigsten medizinischen Versorgungsbedarfe von alternden Menschen mit Thalidomid-induzierten Körper- und Sinnesbeeinträchtigungen geben. Hierbei werden die vorliegende wissenschaftliche Evidenz und klinische Besonderheiten in der medizinischen Versorgung aus allgemeinmedizinisch-internistischer, orthopädisch-schmerztherapeutischer, sozialmedizinischer und psychosomatisch-psychotherapeutischer Perspektive präsentiert und zukünftige Aufgaben diskutiert.
Gallenblasenmetastase eines malignen Melanoms
Authors: Strick Alexander , Busch Hans , Friedhoff Klaus 
Published: September 2022

Zusammenfassung
Anamnese und klinischer Befund Ein 56-jähriger Patient stellte sich mit rezidivierenden rechtsseitigen Oberbauchschmerzen in unserer Sprechstunde vor. Bei sonst allgemeinem Wohlbefinden präsentierte er ein weiches Abdomen bei insgesamt unauffälligem Untersuchungsbefund. Außer einer Appendektomie sowie Exzision eines malignen Melanoms am Ellenbogen vor einigen Jahren bestanden keine weiteren Vorerkrankungen oder Voroperationen.
Untersuchungen Ein bereits extern angefertigtes CT des Abdomens zeigte eine Cholezystolithiasis sowie eine unklare Wandverdickung der Gallenblase. Laborchemisch konnten keine relevanten Auslenkungen festgestellt werden.
Diagnose, Therapie und Verlauf Nach unkomplizierter Cholezystektomie erfolgte histopathologisch im Präparat der Nachweis einer Metastase des vor Jahren behandelten malignen Melanoms. Im angeschlossenen Staging wurden außerdem weitere pulmonale Metastasen diagnostiziert und im weiteren Verlauf in palliativer Intention reseziert.
Folgerung Gallenblasenmetastasen sind eine Rarität – einige Studien lassen aber gerade beim malignen Melanom eine hohe Dunkelziffer vermuten.Entsprechende Beschwerden bei onkologischer Anamnese sollten also eine aufmerksame Diagnostik zur Folge haben und die Indikation zur Cholezystektomie sollte großzügig gestellt werden.
Boron arsenate and its pressure-dependent auxetic properties
Authors: Grima-Cornish James N. , Vella-Żarb Liana , Grima Joseph N. , Evans Kenneth E. 
Published: September 2022

The mechanical properties of single crystals boron arsenate, BAsO4, are simulated through density functional theory simulations over a wide range of pressures from −10 to +90 GPa. It was shown that the elastic constants, as well as the extent of auxeticity, are highly pressure dependent. In particular, the Poisson’s ratio in the (001) plane for stretching in the [100] crystallographic direction is only found to be negative up to pressures of ∼30 GPa, with maximum auxeticity being predicted to occur at ∼15 GPa. It was also shown that the extent of auxetic behavior may be explained through two mechanisms that act concurrently, namely (i) a mechanism which involves rotations of tetrahedra that project in the (001) plane in the form of “rotating semi-rigid squares” and (ii) a mechanism, which is being reported for the first time, whereby the tetrahedra deform and become flatter.
TGFB2-AS1 inhibits triple-negative breast cancer progression via interaction with SMARCA4 and regulating its targetsTGFB2andSOX2
Authors: Zhou Cixiang , Wang Difei , Li Jingchi , Wang Qiuyu , Wo Lulu , Zhang Xin , Hu Zhexuan , Wang Zheng , Zhan Mengna , He Ming , Hu Guohong , Chen Xiaosong , Shen Kunwei , Chen Guo-Qiang , Zhao Qian 
Published: September 2022

Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype for its high rates of relapse, great metastatic potential, and short overall survival. How cancer cells acquire metastatic potency through the conversion of noncancer stem-like cells into cancer cells with stem-cell properties is poorly understood. Here, we identified the long noncoding RNA (lncRNA) TGFB2-AS1 as an important regulator of the reversibility and plasticity of noncancer stem cell populations in TNBC. We revealed that TGFB2-AS1 impairs the breast cancer stem-like cell (BCSC) traits of TNBC cells in vitro and dramatically decreases tumorigenic frequency and lung metastasis in vivo. Mechanistically, TGFB2-AS1 interacts with SMARCA4, a core subunit of the SWI/SNF chromatin remodeling complex, and results in transcriptional repression of its target genes includingTGFB2andSOX2in anin cisorin transway, leading to inhibition of transforming growth factor β (TGFβ) signaling and BCSC characteristics. In line with this, TGFB2-AS1 overexpression in an orthotopic TNBC mouse model remarkably abrogates the enhancement of tumor growth and lung metastasis endowed by TGFβ2. Furthermore, combined prognosis analysis of TGFB2-AS1 and TGFβ2 in TNBC patients shows that high TGFB2-AS1 and low TGFβ2 levels are correlated with better outcome. These findings demonstrate a key role of TGFB2-AS1 in inhibiting disease progression of TNBC based on switching the cancer cell fate of TNBC and also shed light on the treatment of TNBC patients.
The Place of Jakób Handel (1888–c.1942) in the History of Language Study in Poland
Authors: Kilarski Marcin , Szeptyński Rafał 
Published: September 2022

Summary
In this paper we examine the life and work of Jakób Handel (1888–c.1942), an underappreciated Polish-Jewish
scholar whose interests ranged from comparative-historical linguistics and the history of linguistics to classical history and
Jewish studies. Apart from printed publications, his contributions include various forms of outreach directed towards the Jewish
community in Lviv (Ukrainian Львів [L'viv], Polish Lwów, German Lemberg). Based
among others on the available records of his involvement in professional societies and the reviews of his books, we point to the
reasons behind the relative lack of appreciation of his work among contemporary and later scholars despite its in-depth and
original nature.
A hierarchy of correlates for objectively measured physical activity, sedentary time, and physical fitness in older adults: A CHAID analysis
Authors: Rosa Gil B. , Júdice Pedro B. , Hetherington‐Rauth Megan , Magalhães João P. , Correia Inês R. , Sardinha Luís B. 
Published: September 2022

ABSTRACTThe aging process reflects, in many cases, not only a decline in physical activity (PA) and physical fitness (PF), but also an increase in overall levels of sedentary time (ST). In order to hierarchically identify the most powerful correlates related to low and high levels of objectively assessed PA, ST, and PF during the late adulthood, a total of 2666 older adults were cross‐sectionally evaluated. Multidimensional correlates were obtained through interview. Using chi‐squared automatic detection analysis to identify the cluster of correlates with most impact on PA (<21.4 min/day), ST (≥8 h/day), and PF (<33.3th percentile), was found that the most likely subgroup to be physically inactive consisted of widowers not owning a computer and sport facilities in the neighbourhood (94.7%), while not being widowed, reporting to have a family that exercises and a computer at home (54.3%) represented the subgroup less likely to be inactive. Widowers without sidewalks in the neighbourhood were the most sedentary group (91.0%), while being a married woman and reporting to have space to exercise at home (40%) formed the most favourable group of correlates regarding ST. Men reporting a financial income <500€ and physical problems frequently formed the group with the lowest PF level (70.3%). In contrast, the less likely subgroup to have low levels of PF level consisted of having a financial income ≥1000€ and a computer at home (3.4%). Future interventions should target widowers with limited accessibility to computer and urban/sport‐related infrastructures, as well as impaired older adults with low financial income.
Aging and tribological behavior of styrene butadiene rubber conveyor belts under combined seawater dry-wet conditions
Authors: Hu Kun , Yang Jinhan 
Published: September 2022

Abstract
In this study, the aging and tribological behaviors of styrene butadiene rubber (SBR) conveyor belts exposed to seawater dry–wet cycles were investigated. Using hardness as a measure of the aging performance, the worst seawater dry-wet (W-SDW ) cycle conditions were selected using an orthogonal design method, the study was conducted based on such conditions. The changes in SBR surface properties and tribological properties with aging time before and after aging and the degree were investigated by using a hardness tester, SEM, EDS, etc. The performance degradation, microscopic morphological changes of wear surface, and evolutionary behavior of wear mechanism of styrene-butadiene rubber conveyor belt after aging by dry and wet cycles of seawater were discussed. The results show that the most severe combination of wet-dry cycles of seawater for the aging of SBR conveyor belts comprised a soak temperature of 45 °C, soak time of 12 h, drying temperature of 100 °C, and drying time of 9 h. The total surface discoloration of the conveyor belt increases as the number of W-SDW cycles increases, along with the hardness. The friction coefficient of the belt increases with increasing load and decreases with the increasing number of W-SDW cycles. The mass loss increases gradually with the number of W-SDW cycles and load. The wear mechanism gradually changes from fatigue wear to the damage mechanism of coexistence of adhesive wear and fatigue.
Optimization of print quality of inkjet printed PEDOT:PSS patterns
Authors: Buga Cláudia , C Viana Júlio 
Published: September 2022

Abstract
This work investigates which factors and interactions are more influential in the inkjet printing process of conductive poly (3, 4-ethylenedioxythiophene):poly (styrenesulfonate) patterns. The chosen experimental design is an L16 Taguchi experiment with seven different factors with two levels each and eight interactions. The studied factors are printhead voltage, print resolution, substrate temperature, substrate treatment, printhead height, printhead velocity, and the number of printed layers. The analyzed dependent variables are printing accuracy, printing error ratio, and electrical resistance. The results suggest that the resolution, substrate treatment, and printhead height are the most influential factors affecting printing quality, whereas the electrical resistance output is mainly determined by the print resolution, the substrate treatment, and the number of printed layers. Some interactions are also identified between print resolution and substrate treatment, print resolution and number of layers, and substrate temperature and printhead velocity. Some conclusions indicate that lower print resolution benefits printing accuracy, but hinders the electrical conductivity. Furthermore, it was found that plasma treatment can be counterproductive for the printing quality, but beneficial for the electrical conductivity of the patterns. Moreover, great electrical conductivity can be obtained for a lower number of printed layers, as long as the print resolution is increased. Lower printhead height also strongly benefits the printing quality.
Aesthetic Austerity in Persuasion
Authors: Dow Jamie 
Published: September 2022

Abstract
How can we distinguish the permissible use of aesthetic features in persuasive communication from their manipulative misuse? The paper reconstructs the basic argument (proposed by Stoics and others in antiquity) that persuasive speech should be aesthetically austere. The argument, it is suggested, is fundamentally sound. But the view it sustains is subject to challenge, on the grounds that it is implausible and impractical in the real world. By making clear the grounds on which the “austere” view is justified, and by making precise the arguments that underlie those challenges, the paper identifies and evaluates three different possible responses to those challenges. The most promising of these accepts the argument for “austerity” but proposes a more moderate interpretation of its conclusion. In doing so, it takes up the challenge of providing a defensible rationale for distinguishing the permissible from the impermissible use of aesthetic features in persuasive communication.
Translating God on the Borders of Sovereignty
Authors: Kliger Gili 
Published: September 2022

Abstract
Over the long nineteenth century, translations of Christian scripture into indigenous languages were produced at a far greater rate than at any time previously, a product of both the rise of the modern Protestant missionary movement and the acceleration of British imperial and Anglo settler colonial conquest. This article explores a dimension of the global evangelical translation project: the translation of the word “God.” Where, at the close of the sixteenth century, there were just under 30 different words used to translate “God” in published vernacular, between 1800 and the early twentieth century close to 400 new “Gods” entered the Christian lexicon. Reading translation conflicts for what they tell us about the way power was imagined on the modern Anglo-American colonial frontier, this article argues that contests over the translation of “God” offer a window into the cultural and intellectual dimension of colonial conflict, and reveal a neglected chapter in the conceptual history of sovereignty: at the very moment when the concept of sovereignty was increasingly imagined on the model of the law-bound territorial state, alternative theories of sovereign power entered global circulation.
Is there a cyber security dilemma?
Authors: Beckerman Carly E 
Published: September 2022

Abstract
In recent years, scholars, commentators and politicians have discussed the prospect of a ‘cyber security dilemma’. If states race to develop superior cyberattacks, how far might this escalate? Are state-led cyberattacks likely to provoke a full war? To address these related questions, I apply a multi-level Neoclassical Realist framework that progresses from systemic logic to an assessment of leader cues and cognition. This contributes much-needed coherence to debates about escalation and cyber warfare and demonstrates the framework’s utility for addressing contemporary and evolving problems in international affairs. The framework reveals that, according to both a systemic and societal cue analysis, fears regarding unchecked escalation from state competition in cyberspace to kinetic warfare are largely unfounded. Nevertheless, it also points toward one caveat and direction for further research in that cyber warfare directed at foreign leaders’ political survival may be unexpectedly provocative in a way not currently addressed by escalation models.
The Latest Amendment to the German Law on Patent Injunctions: The New Statutory Disproportionality Exception and Third-Party Interests
Authors: Stierle Martin , Hofmann Franz 
Published: September 2022

Abstract
Germany is a prominent jurisdiction for patent litigation. After a long and controversial discussion between stakeholders, the legislator amended the law on injunctive relief in summer 2021 and introduced a statutory disproportionality exception. This article gives an overview of the background to the reform and describes and analyses its implementation, the methodology to assess disproportionality, and the relation to the law on compulsory licensing as well as the special regime for standard-essential patents. The paper focuses particularly on the most controversial ground for denying an injunction: third-party interests in the infringing implementation of the invention.
How patent rights affect university science
Authors: Bergé Laurent R , Doherr Thorsten , Hussinger Katrin 
Published: September 2022

Abstract
How do intellectual property rights influence academic science? We investigate the consequences of the introduction of software patents in the United States on the publications of university researchers in the field of computer science. Difference-in-difference estimations reveal that software scientists at US universities produced fewer publications (both in terms of quantity and quality) than their European counterparts after patent rights for software inventions were introduced. We then introduce a theoretical model that accounts for substitution and complementarity between patenting and publishing as well as for the direction of research. In line with the model’s prediction, further results show that the decrease in publications is largest for scientists at the bottom of the ability distribution. Furthermore, we evidence a change in the direction of research following the reform toward more applied research.
P009 Investigation of in vitro antifungal susceptibility testing and genetic diversity of clinical isolates of Trichophyton benhamiae and Trichophyton eriotrephon in Iran
Authors: Sarvestani Hasti Kamali , Ansari Saham , Shokoohi Gholam-Reza , Ahmadi Bahram , Rezaei-Matehkolaei Ali , Hedayati Mohammad T 
Published: September 2022

Abstract

Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM

Background
Trichophyton benhamiae is a zoophilic dermatophyte, known as one of the causative agents of dermatophytosis.

Objectives
The purpose of this study was to explore the genotypes of T. benhamiae strains isolated from geographically different areas of Iran and also to evaluate in vitro antifungal susceptibility profile of these strains against seven antifungal drugs.

Methods
A total of 22 strains of T. benhamiae and 2 strains of T. eriotrephon were isolated from patients with distinct types of dermatophytosis. DNA extraction and amplification of rDNA regions using ITS1 and ITS4 primers were conducted on the isolates. The in vitro antifungal susceptibility of posaconazole (PSC), voriconazole (VRC), itraconazole (ITC), ketoconazole (KET), caspofungin (CAS), terbinafine (TRB) and griseofulvin (GRZ) was evaluated according to CLSI M38-A2 protocol.

Results
The multiple alignments of the ITS-rDNA sequences of T. benhamiae indicated a mean similarity of 99.5%, with 0-3 interspecies nucleotide differences. The geometric mean (GM) values of minimum inhibitory concentrations (MICs) and minimum effective concentrations (MECs) across the all isolates were respectively: TRB: 0.025 mg/l, PSC: 0.032 mg/l, ITC: 0.050 mg/l, and VRC: 0.059 mg/l with lower values and CAS: 0.31 mg/l, KTZ: 0.56 mg/l, and GRZ: 0.76 mg/l with higher values.

Conclusion
Diverse ITS sequence types of T. benhamiae were shown in different geographical regions of Iran. The TRB, PSC, and ITC were the most effective drugs against T. benhamiae strains, respectively. Furthermore, in our study, two strains of T. eriotrephon as a scarce dermatophyte species were described.
P024 Genetic determinants of antifungal drug resistance in Fusarium solani species complex
Authors: Trivedi Pinal , Gajjar Devarshi 
Published: September 2022

Abstract

Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM
Due to its challenging diagnosis and treatment, fungal keratitis is one of the most serious kinds of corneal infection. The Fusarium solani species complex is responsible for nearly half of all fungal keratitis cases. Fusarium infection is difficult to treat because of the increased antifungal resistance of Fusarium species.

Objective
To check the antifungal susceptibility in keratitis-causing isolates of F. solani species complex.
To find the genetic determinants of resistance using whole genome sequencing.

Methodology
Prior to AFST and according to CLSI, clinical isolates of Fusarium species (n = 5) were cultured on potato dextrose agar for 7 days at room temperature. Fungal spores were harvested using 0.8% NaCl and antifungal drug susceptibility testing of 6 different antifungal drugs were tested using CLSI standards broth microdilution method and minimum inhibitory concentrations were obtained. After 24 and 48 h, broth microdilution plates were manually examined. The wells for growth control were also examined. The minimum inhibitory concentration of anti-fungal drugs was the lowest dose that inhibits growth completely (compared to the growth control well). Minimal effective concentration (MEC) was also determined against antifungal drugs. Whole genome sequencing was done using Illumina Hiseqx10. Bioinformatics analysis was done using different bioinformatics tools and software (FASTQC, SPAdes, OmicsBox, AUGUSTUS, etc.).

Results
In this study the antifungal drug susceptibility from average MIC value were found as fluconazole (512 μg/ml) &gt; itraconazole (32 μg/ml) &gt; amphotericin B (8 μg/ml) &gt; natamycin (8 μg/ml) &gt; posaconazole (2 μg/ml) &gt; voriconazole (1 μg/ml). Fluconazole had a higher MIC value (512 g/ml) in all isolates, however, voriconazole was shown to be more sensitive, with a lower MIC range (0.25-4 g/ml). Glyoxalase/Bleomycin resistance protein, mfs—multidrug resistance transporter, fusaric acid resistance protein, efflux pump antibiotic resistance protein, and copper resistance protein were found by genome-based analysis.

Conclusion
As a conclusion of this study, we observed antifungal drug resistance in Fusarium spp., which is often used to treat keratitis in patients, employing fluconazole, itraconazole, and amphotericin B. Resistance to first-line azoles was as a gene variant which contributed to antifungal drug resistance. This study using the phenotypic and genotypic characterization of drug resistance patterns will help to combat antifungal drug resistance.