bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of occupations susceptible to high exposure and risk associated with multiple toxicants in an observational study: National Health and Nutrition Examination Survey 1999–2014
Authors: Nguyen Vy Kim , Colacino Justin , Patel Chirag J , Sartor Maureen , Jolliet Olivier 
Published: June 2022

AbstractOccupational exposures to toxicants are estimated to cause over 370 000 premature deaths annually. The risks due to multiple workplace chemical exposures and those occupations most susceptible to the resulting health effects remain poorly characterized. The aim of this study is to identify occupations with elevated toxicant biomarker concentrations and increased health risk associated with toxicant exposures in a diverse working US population. For this observational study of 51 008 participants, we used data from the 1999–2014 National Health and Nutrition Examination Survey. We characterized differences in chemical exposures by occupational group for 131 chemicals by applying a series of generalized linear models with the outcome as biomarker concentrations and the main predictor as the occupational groups, adjusting for age, sex, race/ethnicity, poverty income ratio, study period, and biomarker of tobacco use. For each occupational group, we calculated percentages of participants with chemical biomarker levels exceeding acceptable health-based guidelines. Blue-collar workers from “Construction,” “Professional, Scientific, Technical Services,” “Real Estate, Rental, Leasing,” “Manufacturing,” and “Wholesale Trade” have higher biomarker levels of toxicants such as several heavy metals, acrylamide, glycideamide, and several volatile organic compounds (VOCs) compared with their white-collar counterparts. Moreover, blue-collar workers from these industries have toxicant concentrations exceeding acceptable levels: arsenic (16%–58%), lead (1%–3%), cadmium (1%–11%), glycideamide (3%–6%), and VOCs (1%–33%). Blue-collar workers have higher toxicant levels relative to their white-collar counterparts, often exceeding acceptable levels associated with noncancer effects. Our findings identify multiple occupations to prioritize for targeted interventions and health policies to monitor and reduce toxicant exposures.
A chromosome-level genome assembly of the orange wheat blossom midge,Sitodiplosis mosellanaGéhin (Diptera: Cecidomyiidae) provides insights into the evolution of a detoxification system
Authors: Gong Zhongjun , Li Tong , Miao Jin , Duan Yun , Jiang Yueli , Li Huiling , Guo Pei , Wang Xueqin , Zhang Jing , Wu Yuqing 
Published: June 2022

AbstractThe orange wheat blossom midge Sitodiplosis mosellana Géhin (Diptera: Cecidomyiidae), an economically important pest, has caused serious yield losses in most wheat-growing areas worldwide in the past half-century. A high-quality chromosome-level genome for S. mosellana was assembled using PacBio long read, Illumina short read, and Hi-C sequencing technologies. The final genome assembly was 180.69 Mb, with contig and scaffold N50 sizes of 998.71 kb and 44.56 Mb, respectively. Hi-C scaffolding reliably anchored 4 pseudochromosomes, accounting for 99.67% of the assembled genome. In total, 12,269 protein-coding genes were predicted, of which 91% were functionally annotated. Phylogenetic analysis indicated that S. mosellana and its close relative, the swede midge Contarinia nasturtii, diverged about 32.7 MYA. The S. mosellana genome showed high chromosomal synteny with the genome of Drosophila melanogaster and Anopheles gambiae. The key gene families involved in the detoxification of plant secondary chemistry were analyzed. The high-quality S. mosellana genome data will provide an invaluable resource for research in a broad range of areas, including the biology, ecology, genetics, and evolution of midges, as well as insect–plant interactions and coevolution.
The Impact of a Virtual Art Tour Intervention on the Emotional Well-Being of Older Adults
Authors: Averbach Julie , Monin Joan 
Published: June 2022

Abstract

Background and Objectives
Based on empirical support for the public health value of art-viewing, the present study examines the impact of a novel virtual art tour intervention on the emotional well-being of older adults.

Research Design and Methods
We used a pre–post quantitative survey design to evaluate an art tour intervention delivered to older adults (N = 155) directly in their homes and community centers. Emotion was measured using the modified Differential Emotions Scale, and life satisfaction was measured with the Satisfaction with Life Scale. To gain insight into participants’ experiences during the tours, we also conducted qualitative interviews with program coordinators at partnering organizations who viewed the tours with participants.

Results
Following the art tours, participants reported significant improvements in positive emotions (especially awe) and life satisfaction. There were no significant effects on negative emotions. Program coordinators provided feedback that the tour was engaging, intellectually stimulating, and enjoyable for participants.

Discussion and Implications
Findings support the beneficial mental health potential of virtual art-viewing experiences for older adults. Technology may provide an effective platform to deliver wellness-oriented cultural enrichment programming while addressing accessibility barriers linked to in-person arts engagement.
Surgical Management of Enterovesical Fistula in Crohn’s Disease in the Biologic Era
Authors: McKenna Nicholas P , Kelley Scott R , Bews Katherine A , Behm Kevin T , Mathis Kellie L 
Published: June 2022

Lay SummaryEnterovesical fistula in Crohn’s disease that require surgery may be managed safely laparoscopically with similar morbidity to open repair and a shorter length of stay. Preoperative biologic exposure does not affect surgical morbidity.
Association between urinary polycyclic aromatic hydrocarbon metabolites and diabetes mellitus among the US population: a cross-sectional study
Authors: Mallah Manthar Ali , Basnet Til Bahadur , Ali Mukhtiar , Xie Fuwei , Li Xiang , Feng Feifei , Wang Wei , Shang Pingping , Zhang Qiao 
Published: June 2022

AbstractBackgroundThe primary aim of this study is to examine the association between urinary polycyclic aromatic hydrocarbons (PAHs) and diabetes mellitus (DM) among the US population.MethodsWe used data from the National Health and Nutritional Examination Survey 2003–16, which is a nationally representative population-based survey of the US non-institutionalized population. Logistic regression analysis was performed to evaluate the association between urinary PAHs and the prevalence of DM using odds ratios (ORs) and 95% confidence intervals (CIs).ResultsThe study sample including 13 792 individuals ≥18 y of age. The average ages of the three PAH tertiles were 42.56±19.67, 42.21±19.51 and 43.39±17.99 y. An increased risk of DM was found with increased odds for the second (OR 1.56 [95% CI 1.36 to 1.79]) and third tertile (OR 1.79 [95% CI 1.55 to 2.06)] of urinary PAH as compared with the first tertile. Similarly, higher chances of DM were observed in the second (men: OR 1.42 [95% CI 1.18 to 1.71]; women: OR 1.76 [95% CI 1.44 to 2.14]) and third tertile (men: OR 1.69 [95% CI 1.38 to 2.08]; women: OR 1.79 [95% CI 1.46 to 2.19]) of urinary PAHs as compared with the first tertile in both men and women.ConclusionsA population-based cross-sectional study found a positive association between urinary PAHs and DM in the US population.
Impact of artificial intelligence on pathologists’ decisions: an experiment
Authors: Meyer Julien , Khademi April , Têtu Bernard , Han Wencui , Nippak Pria , Remisch David 
Published: June 2022

Abstract

Objective
The accuracy of artificial intelligence (AI) in medicine and in pathology in particular has made major progress but little is known on how much these algorithms will influence pathologists’ decisions in practice. The objective of this paper is to determine the reliance of pathologists on AI and to investigate whether providing information on AI impacts this reliance.

Materials and Methods
The experiment using an online survey design. Under 3 conditions, 116 pathologists and pathology students were tasked with assessing the Gleason grade for a series of 12 prostate biopsies: (1) without AI recommendations, (2) with AI recommendations, and (3) with AI recommendations accompanied by information about the algorithm itself, specifically algorithm accuracy rate and algorithm decision-making process.

Results
Participant responses were significantly more accurate with the AI decision aids than without (92% vs 87%, odds ratio 13.30, P &lt; .01). Unexpectedly, the provision of information on the algorithm made no significant difference compared to AI without information. The reliance on AI correlated with general beliefs on AI’s usefulness but not with particular assessments of the AI tool offered. Decisions were made faster when AI was provided.

Discussion
These results suggest that pathologists are willing to rely on AI regardless of accuracy or explanations. Generalization beyond the specific tasks and explanations provided will require further studies.

Conclusion
This study suggests that the factors that influence the reliance on AI differ in practice from beliefs expressed by clinicians in surveys. Implementation of AI in prospective settings should take individual behaviors into account.
Predicting COVID-19 county-level case number trend by combining demographic characteristics and social distancing policies
Authors: Li Megan Mun , Pham Anh , Kuo Tsung-Ting 
Published: June 2022

AbstractObjectivePredicting daily trends in the Coronavirus Disease 2019 (COVID-19) case number is important to support individual decisions in taking preventative measures. This study aims to use COVID-19 case number history, demographic characteristics, and social distancing policies both independently/interdependently to predict the daily trend in the rise or fall of county-level cases.Materials and MethodsWe extracted 2093 features (5 from the US COVID-19 case number history, 1824 from the demographic characteristics independently/interdependently, and 264 from the social distancing policies independently/interdependently) for 3142 US counties. Using the top selected 200 features, we built 4 machine learning models: Logistic Regression, Naïve Bayes, Multi-Layer Perceptron, and Random Forest, along with 4 Ensemble methods: Average, Product, Minimum, and Maximum, and compared their performances.ResultsThe Ensemble Average method had the highest area-under the receiver operator characteristic curve (AUC) of 0.692. The top ranked features were all interdependent features.ConclusionThe findings of this study suggest the predictive power of diverse features, especially when combined, in predicting county-level trends of COVID-19 cases and can be helpful to individuals in making their daily decisions. Our results may guide future studies to consider more features interdependently from conventionally distinct data sources in county-level predictive models. Our code is available at: https://doi.org/10.5281/zenodo.6332944.
Impact of increasing standardized ileal digestible valine: lysine in diets containing 30% dried distiller grains with solubles on growing pig performance
Authors: Clizer David A , Tostenson Blair J , Tauer Sam K , Samuel Ryan S , Cline Paul M 
Published: June 2022

Abstract
A total of 2,430 pigs (DNA 600 × Topigs Norsvin 70, initially 39.4 kg) were used in a 28-d trial to determine the standardized ileal digestible (SID) Val:Lys requirement for pigs fed with diets containing 30% DDGS. Treatments included five diets containing 30% DDGS with SID Val:Lys ratios of 60%, 65%, 70%, 75%, and 80%, plus a corn soybean meal (SBM) diet, for a total of six dietary treatments. Diets were formulated to be isocaloric through the inclusion of fat and to contain equal amounts of SID Lys within phase. Pens were assigned to dietary treatment in a randomized complete block design with initial body weight (BW) as the random blocking factor. Each dietary treatment was replicated 15 times and pens contained 27 pigs, balanced for sex. Increasing the SID Val:Lys ratio in diets containing 30% DDGS increased (Quadratic; P ≤ 0.007) 14-d BW, final BW, average daily gain (ADG), average daily feed intake (ADFI), and gain:feed (G:F) for all periods. Providing an SID Val:Lys ratio of 75% resulted in the heaviest 14-d BW and final BW as well as greater ADG and ADFI of pigs fed with 30% DDGS for all periods. The G:F response was maximized when an SID Val:Lys ratio of 70% was provided from day 0 to 14 while an SID Val:Lys ratio of 75% maximized G:F from day 14 to 28 and for the cumulative period. The SID Val:Lys requirement was estimated at 66.6% (95% CI [65.9, 67.4]), 65.7 (95% CI: [64.8, 66.5]), and 68.4% (95% CI [66.0, 70.8]) for ADG, ADFI, and G:F, respectively, using the straight broken line (SBL) method and 69.9% (95% CI [68.2, 71.5]), 67.6 (95% CI [65.4, 69.8]), and 72.8% (95% CI [69.8, 75.8]) for the quadratic broken line (QBL) method. Pigs fed the corn–SBM diet had heavier 14-d BW, final BW, and greater ADG, ADFI, G:F (P ≤ 0.032) compared to pigs fed diets containing 30% DDGS, except for cumulative ADFI compared to pigs receiving 75% SID Val:Lys (P = 0.167). In conclusion, these results suggest that when feeding 30% DDGS during the growing period, an SID Val:Lys ratio of 68% would yield more than 99% and 97% of the maximum ADG and G:F response for the 39 to 68 kg pigs. However, growth performance of pigs fed diets containing 30% DDGS did not equate to pigs consuming the corn–SBM diet regardless of the SID Val:Lys ratio.
Globularia arabicaMethanolic Leaf Extract Has Higher Efficacy on Burn Wound Healing in Diabetic Rats Compared toMalva slyvestriesMethanolic Leaf Extract
Authors: Alsarayreh Ahmad Z , Khleifat Khaled M , Al-Dalain Sa’ed M , Al-Saraireh Yousef M , Al Qaisi Yaseen T , Alfarrayeh Ibrahim I , AL-Qaraleh Samer Y 
Published: June 2022

AbstractThis study aimed to see how effective Globularia arabica and Malva slyvestries-based cream formulations were at healing scald burn wounds in rats. Depending on ointment, preparations of 1%, 5%, and 10% w/w were created. For comparison, an ointment base and a regular burn cream composed soframycine were utilized. Rats introduced a burn by solidifying equipment at 100°C on a 14-mm2 shaved dorsal region. A deep second-degree burn was created, and the percentage of wound contraction was measured over the next 15 days. The rats were euthanized on days 8 and 15, and histological slides were prepared using hematoxylin and eosin staining. Compared to the control group, there was a substantial increase in wound contraction and a significant decrease in the duration of epithelialization in the based ointment-treated groups. However, as paralleled to Globularia arabica, significant (P &lt; .05) results were observed with 10% Globularia arabica cream, whereas Malva slyverstries indicate minimal healing. Soframycine causes a substantial increase in wound contraction (P &lt; .05). Soframycine cream with 10% Globularia arabica therapy resulted in practically complete re-epithelialization and re-structuring of wound tissue on histological examination, whereas Malva slyversries treatment resulted in low epithelization during treatment days. The findings suggest that Globularia arabica-based cream has the wound-healing capability.
Olfactory Bulb Amyloid-β Correlates With Brain Thal Amyloid Phase and Severity of Cognitive Impairment
Authors: Tremblay Cécilia , Serrano Geidy E , Intorcia Anthony J , Mariner Monica R , Sue Lucia I , Arce Richard A , Atri Alireza , Adler Charles H , Belden Christine M , Shill Holly A , Driver-Dunckley Erika , Mehta Shyamal H , Beach Thomas G 
Published: June 2022

Abstract
The Alzheimer disease (AD) neuropathological hallmarks amyloid β (Aβ) and tau neurofibrillary (NF) pathology have been reported in the olfactory bulb (OB) in aging and in different neurodegenerative diseases, which coincides with frequently reported olfactory dysfunction in these conditions. To better understand when the OB is affected in relation to the hierarchical progression of Aβ throughout the brain and whether OB pathology might be an indicator of AD severity, we assessed the presence of OB Aβ and tau NF pathology in an autopsy cohort of 158 non demented control and 173 AD dementia cases. OB Aβ was found in less than 5% of cases in lower Thal phases 0 and 1, in 20% of cases in phase 2, in 60% of cases in phase 3 and in more than 80% of cases in higher Thal phases 4 and 5. OB Aβ and tau pathology significantly predicted a Thal phase greater than 3, a Braak NF stage greater than 4, and an MMSE score lower than 24. While OB tau pathology is almost universal in the elderly and therefore is not a good predictor of AD severity, OB Aβ pathology coincides with clinically-manifest AD and might prove to be a useful biomarker of the extent of brain spread of both amyloid and tau pathology.
Low-level expression of induced defences and increased compensation inEupatorium adenophorumrelative to its native congeneric plant to mechanical wounding and insect herbivory
Authors: Wang Rui-Fang , Liao Zhi-Yong , Li Wei-Tao , Zhang Chun-Hua , Zhang Han-Bo , Zheng Yu-Long 
Published: June 2022

AbstractNative herbivory may be detrimental to plant fitness and thus can contribute a biotic resistance to exotic plant invasion. Eupatorium adenophorum, a non-native species, has formed dense monocultures in many southern Provinces of China. Because several native generalist insects feed on E. adenophorum, we evaluated whether the lower level of induced defences and greater compensatory growth contributed to successful invasion of E. adenophorum by comparison with a native congener E. heterophyllum. Early events in the jasmonic acid cascade and chlorophyll fluorescence, non-target metabolomic profiles and recovery in biomass compensation of E. adenophorum and its native congener E. heterophyllum were measured during mechanical wounding and herbivory by the generalist insect Helicoverpa armigera. Mechanical and simulated chewing damage immediately initiated defences in the two species. However, E. heterophyllum was more sensitive to tissue loss, and it produced more metabolic defensive compounds than invasive E. adenophorum. Although H. armigera feeding amplified the effects of mechanical wounding on defence induction, the biomass of E. adenophorum was only weakly affected, as its higher compensatory growth could offset the biomass loss and metabolic cost. Overall, our results suggest that H. armigera herbivory and mechanical wounding could induce different physiological responses, and are often specific to invasive E. adenophorum and native E. heterophyllum. Moreover, lower metabolic defences and higher compensation growth may contribute to the invasion success of E. adenophorum.
An Emerging Pattern? A Further Case of Anticipated Capacity Loss in Pregnancy: North Middlesex University Hospital NHS Trust V SR [2021] EWCOP 58
Authors: Hulme Aimee V 
Published: June 2022

Abstract
In 2021, the Court of Protection made a third anticipatory declaration that it was lawful for a capacitous pregnant woman to be subject to possible forcible treatment contingent on her losing capacity before or during birth. North Middlesex University Hospital v SR raises three interesting questions for discussion which this commentary will explore. First, it is submitted that there is a growing, yet alarming, trend in the use of anticipatory or contingent declarations to manage such challenging cases of future loss of, or fluctuating, capacity in pregnant women. This trend now seems to have been widened by SR and could potentially capture any pregnant woman, rather than those in narrower, exceptional circumstances. Secondly, this commentary discusses the judge’s justification of basing the issuing of anticipatory or contingent declarations on a ‘real risk’ P will lose capacity in the future, highlighting the potential problems with framing such controversial powers on ‘risk’. Finally, it provides an exploration of the alternative option of utilising advance care plans to better deal with these types of matters, in the name of giving back the power to pregnant women to decide on what should happen to them in labour in the event that they do lose capacity before or during delivery.
Implementation of the Acute Care Clinic Easy Scheduling System at the Brooke Army Medical Center
Authors: Tapia Ashley D , Tapia Giselle , Snyder Bradley L , Bebo Natasha L , Chin Eric J , Schauer Steven G 
Published: June 2022

ABSTRACT

Introduction
Emergency departments (EDs) have continued to struggle with overcrowding, causing delays in patient care and increasing stress on the medical staff and resources. This was further illustrated during the recent coronavirus disease 2019 pandemic, where we saw large unpredictable surges to the ED as hospitals tried to meet the medical needs of patients while trying to minimize the spread of coronavirus disease. A previous study from the Department of Emergency at the Brooke Army Medical Center (BAMC) found that nearly half of the patients presenting to the ED could have been managed in a primary care setting. We sought to pilot an alternate appointment scheduling system, Acute Care Clinic Easy Scheduling System, to allow patients to see and book available appointments while waiting in the ED waiting room.

Materials and Methods
Our appointment display system was created through collaboration with the BAMC Information Management Division. A Tableau data interface connects to the Composite Health Care System to view available primary appointments across the San Antonio Military Health Care System. These are displayed in real-time on multiple TV screens outside the ED and in the ED waiting room. Patients were provided signage that provides a way to call or use a World Wide Web–based interface to immediately schedule the open appointments within the next 48 hours. Patients voluntarily opted to use this system and may opt to leave the ED if another appointment became available within an acceptable time frame to them.

Results
This section is not applicable to this article.

Conclusions
Expansion of the Acute Care Clinic Easy Scheduling System within the Military Health Care System may (1) help reduce ED crowding, (2) improve access to care through a live-tracking system that patients can review and select from, and (3) reduce the number of unfilled primary care appointments. The system in place in the BAMC ED serves as a template for other MTFs to use.