bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of ICT for Teaching and Learning among Secondary Schools Teachers in Mtwara, Tanzania
Authors: Peter Joseph Christonsia 
Published: August 2022

The use of ICT in teaching and learning improve the quality and performance of education delivery, administration and management. As the world is moving fast technologically, it is important to assess teachers’ awareness and abilities in using ICT for teaching, and if ICT tools are available in secondary schools. The study had three specific objectives ; to assess teachers’ awareness of ICT policy for Basic Education in Tanzania, teachers’ abilities in using teaching and learning ICT tools, and the availability of basic teaching and learning ICT tools. From seven public secondary schools, about 110 teachers were involved in this descriptive study which was conducted under a mixed approach. Questionnaire and in-depth interview were applied to assess teachers’ awareness and current skills and practices in the application of the available ICT for teaching and learning. The results of this study indicate that a moderate number of secondary schools’ teachers were aware of the ICT policy for basic education in Tanzania. Also, the results show that the majority of secondary schools possess fewer teaching and learning ICT tools. In addition, the findings indicate that most teachers have moderate abilities in using ICT tools for teaching and learning. However, 91.5 per cent of male teachers possessed more ICT skills than did female teachers. The paper recommends that the Government of Tanzania invest more efforts and resources to integrate ICT in secondary school education and raise teachers’ awareness of ICT policy through seminars or workshops.
Attributes Influencing Effectiveness of Employees’ Innovation in Telecommunication Industry in Tanzania
Authors: Kikuli Miriam D. , Mwombeki Frank A. 
Published: August 2022

This study aimed at examining attributes influencing the effectiveness of employees’ innovation in telecommunication industry in Tanzania using Tigo as a reference. Specifically, the study focused on the assessment of the influence of personal competence, leadership styles, technology and financial resources on employees’ innovation in terms of the number of employees’ creative ideas and projects turned into innovation. The study employed a cross-sectional survey strategy to collect data from a sample of 78 employees and openended questionnaires to collect additional information from 5 key informants who were senior members of Tigo, Tanzania. Descriptive statistics and Multiple Linear Regression were used to analyse data and test formulated hypotheses respectively. The findings show that leadership styles and technology strongly influence employees’ innovation in Telecommunication Companies. The study findings imply that it is very crucial for human resource directors to motivate staff to make them innovative. Also, ICT, research and development departments should be given more budgets and intensive trainings in order to build employees’ innovative capacity. Therefore, it is recommended that technology and leadership style should be seriously considered by company’s management when making strategies and plans for innovative growth in an organization particularly Telecommunication Industry.
FAM172A inhibits breast cancer cell growth and metastasis by upregulating Notch 3
Authors: Tang Chongyin , Wang Guozhu 
Published: August 2022

Purpose: To investigate the role of family with sequence similarity 172 member A (FAM172A) in breast cancer.
Methods: FAM172A expression was evaluated by western blot and quantitative reverse transcription polymerase chain reaction (qRT-PCR). Colony formation and CCK-8 assays were used to assess cell proliferation, while cell migration and invasion were evaluated by Transwell assay.
Results: FAM172A expression was reduced in breast cancer cells and tissues when compared to controls (p < 0.001). Overexpression of FAM172A repressed proliferation of breast cancer cells (p < 0.001) and suppressed cell migration and invasion (p < 0.001). Overexpression of FAM172A increased Notch 3 expression in breast cancer cells. Knockdown of Notch 3 attenuated the FAM172A overexpression-induced decrease in breast cancer cell proliferation. Silencing of Notch 3 reversed the FAM172A (p < 0.001).
Conclusion: FAM172A represses breast cancer cell growth and metastasis via upregulation of Notch 3; thus, FAM172A and Notch 3 are potential targets for breast cancer therapy.
Keywords:
3-O-Caffeoylquinic acid in Periploca forrestii Schltr extract ameliorates collagen-induced arthritis by inducing IL17/IL23 cells in rats
Authors: Ning Qiaoyi , Yao Xueming , Huang Ying , Hou Lei , Lu Daomin , Yang Yutao , Zhan Yamei , He Yiting , Ma Wukai 
Published: August 2022

Purpose: To study the therapeutic effect of 3-O-caffeoylquinic acid (3-O-CQA) from Periploca forrestii extract (PFE) on collagen-mediated arthritis (CIA) in rats, as well as the potential underlying mechanism of action.
Methods: PFE and 3-O-CQA were successively and intragastrically administered to CIA rats. Paw swelling, arthritic scores and H & E staining were used to evaluate the therapeutic effect of 3-O-CQA. Moreover, to determine the effects of PFE and 3-O-CQA on fibroblast-resembling synoviocytes obtained from arthritic subjects (RAFLS), the viability of RAFLS cultured in vitro was measured with MMT, while apoptotic lesions were analyzed by flow cytometry. The levels of IL-6 in CIA and RAFLS were determined by enzyme-linked immunosorbent assay (ELISA), while quantitative reverse transcriptionpolymerase chain reaction (qRT-PCR) and immunoblotting were used to assess their mRNA and
polypeptide levels, respectively.
Results: PFE in 3-O-CQA ameliorated swelling and reduced arthritic scores in CIA rat model, and also decreased cytokine levels (p < 0.05). By decreasing mRNA and protein expressions, 3-O-CQA repressed the phosphorylation of STAT3 and JAK2 as well as the protein levels of IL-23 and RORγt (p < 0.05).
Conclusion: The results of this study show that CIA and RAFLS are ameliorated in rats by 3-O-CQA in PFE through regulation of IL17/ IL23 and Th17 cells. Thus, 3-O-CQA affords a therapeutic strategy for the management of collagen-induced arthritis.
Keywords: Arthriti; Periploca forrestii Schltr extract; 3-O-Caffeoylquinic acid; Interleukin (IL)-17; IL-23; Th17 cells
Danshensu exerts cardioprotective effects in rats with acute myocardial infarction via reduction of infiltration of inflammatory cells and mitigation of myocardial fibrosis
Authors: Zhang Zhong , Zhang Min , Wang Ying 
Published: August 2022

Purpose: To investigate the mitigative impact of danshensu on heart tissues in acute myocardial infarction (AMI) rats, and the mechanism of action involved.
Methods: Seventy-five male Sprague-Dawley (SD) rats were used in this study. After successful induction of myocardial infarction, the rats were divided into model group (MG), low-dose danshensu group (LDG; 15 mg/kg), middle-dose danshensu group (MDG; 30 mg/kg), and high-dose danshensu group (HDG; 60 mg/kg), with 15 rats per group. Rats in sham group (SG; n = 15) served as control. Serum levels of biochemical indicators and expressions of various proteins in myocardial tissue were determined using Western blotting, and compared amongst the rat groups.
Results: Serum cTnI concentrations in MDG and HDG were significantly decreased, relative to the corresponding concentrations in MDG. There were significantly lower serum concentrations of IL-1 in MDG and HDG than in model rats. Rats in HDG had lower serum IL-6 concentration than MG rats, while TNF-α levels were down-regulated in MDG and HDG, relative to MG (p < 0.05).
Conclusion: Danshensu protects the heart function of rats with AMI by decreasing inflammationderived cells and mitigating myocardial fibrosis. Thus, it may be useful in the management of AMI in humans but clinical trials are necessary to ascertain this.
Keywords: Danshens; Acute myocardial infarction; Myocardial ischemia-reperfusion; Myocardial fibrosis
Quaternary amines exert anti-myocardial ischemia effects via regulation of energy metabolism and oxygen free radicals in myocardial cells in acute myocardial infarction rats
Authors: Zhang Zhong , Zhang Min , Wang Ying 
Published: August 2022

Purpose: To investigate the effect of quaternary amines on myocardial cells of a rat model of cardiac arrest, with respect to energy generation potential and oxygen free radicals.
Methods: Forty-five Sprague-Dawley (SD) rats were assigned to sham, model and quaternary amine groups (each with 15 rats). After their corresponding treatments, lectrocardiogram (ECG) monitoring of the rats in the three groups at various time periods was carried out. Serum levels of myocardial enzymes, thromboxane B2 (TXB2), prostacyclin I2 (PGI2), serum carbon monoxide (CO), and changes in endothelial carbon monoxide synthase (eNOS) and endothelin (ET), were determined.
Results: The levels of NO and eNOS were significantly reduced in model rats, relative to sham operation rats, while ET was significantly elevated in sham rats (p < 0.05). There were higher levels of NO and eNOS in the quaternary amine group than in model rats, but ET was higher in quaternary amine group than in model rats. Thromboxane B2 (TXB2) concentration was higher in model rats than in sham rats (p < 0.05). While PGI2 was markedly lower in quaternary group than in sham operation rats. TXB2 was lower in the quaternary amine group than in model rats, while PGI2 was significantly higher in quaternary amine group, relative to model rats (p < 0.05).
Conclusion: Quaternary amines exert anti-myocardial effects by regulating energy metabolism and oxygen free radicals in myocardial cells of congestive heart failure rats, and thus are potentially useful for the management of acute myocardial infarction.
Keywords: Quaternary amine; Acute myocardial infarction; Electrocardiogram; Serum myocardial enzymes; Myocardial cells
Effect of a combination of Xuebijing and thymosin α1 on patients with severe pneumonia complicated with sepsis, and its influence on serum inflammatory factors
Authors: Li Yan , Wang Suhang , Zhang Jing , Cao Jie 
Published: August 2022

Purpose: To investigate the influence of a combination of Xuebijing and thymosin α1 on acute and septic bronchopneumonia (ASB) patients, and the effect of the treatment on inflammation.
Methods: Eighty-one (81) ASB patients admitted to Tianjin Medical University General Hospital, Tianjin China from January 2015 to July 2019 were enrolled in the study. The patients were assigned to control group (n = 41) and a study group (n = 40). The control patients were treated with Xuebijing injection, i.v., while the study group received a combination of Xuebijing injection and thymosin α1 via the subcutaneous route. Patients’ body temperature, heartbeat, white blood cell count, as well as other parameters, including blood gas indices, serum concentrations of IL-6, TNF-α and C-reactive protein (CRP), as well as well as blood gas indices were determined by enzyme-linked immunosorbent assay (ELISA). Bacterial clearance and therapeutic effectiveness were evaluated pre- and post-treatment.
Results: Post-therapy basal temperature, breathing, heartbeat, number of white blood cells and other indices decreased in study patients, relative to control (p < 0.05). Moreover, the levels of hydrogen ion concentration (pH) and arterial carbon dioxide partial pressure (PaCO2) were significantly lower in study group than in control group (p < 0.05). Patients in the study group had lower serum levels of IL-6, TNF-α and CRP, when compared to control group, while bacterial load was significantly reduced in study subjects, relative to controls (p < 0.05).
Conclusion: Combined use of thymosin α1 and Xuebijing is significantly effective in the management of patients suffering from ASB. The combination therapy also improves the hemorheological status of patients. Thus, it is a potential therapeutic strategy for ASB.
Keywords: Acute bronchopneumonia; Xuebijing; Thymosin α1; Septicemia; Inflammation
Knockdown of TNFAIP1 mitigates sevoflurane-induced cognitive dysfunction by activating CREB/Nrf2 pathway
Authors: Lu Jiayu , Liu Zhenpeng , He Wei , Shao Sichao 
Published: August 2022

Purpose: To investigate the role of tumor necrosis factor-induced protein 1 (TNFAIP1) and cAMPresponsive element binding protein (CREB)/nuclear factor-erythroid factor 2-related factor 2 (Nrf2) pathway in sevoflurane (SEV)-induced cognitive dysfunction.
Methods: A SEV-induced cognitive dysfunction rat model was developed. Bcl-2, Bax, heme oxygenase-1, Nrf2, p-CREB, and CREB protein levels in rat hippocampal tissue were assessed by western blot. Learning and long-term memory were evaluated using Morris water maze test. Glutathione peroxidase, malondialdehyde, and superoxide dismutase levels in hippocampal tissue were measured by enzyme-linked immunosorbent assay (ELISA). The 2,7-dichlorodihydro-fluorescein diacetate fluorescent assay was used to measure reactive oxygen species, while TUNEL staining was used to assess neuronal cell apoptosis.
Results: Knockdown of TNFAIP1 attenuated SEV-induced learning and long-term memory dysfunction (p < 0.005), oxidative stress (p < 0.005), apoptosis (p < 0.005), and inhibition of the CREB/Nrf2 signaling pathway.
Conclusion: This study demonstrates that knockdown of TNFAIP1 alleviates SEV-induced cognitive dysfunction by reversing inhibition of the CREB/Nrf2 signaling pathway.
Keywords: TNFAIP1; Postoperative cognitive dysfunction; Sevoflurane; cAMP-responsive element binding protein (CREB); Nuclear factor-erythroid factor 2-related factor 2 (Nrf2)
The Philosophy of Globalisation and African Culture
Authors: Olufemi Badru Ronald 
Published: August 2022

This paper examines two claims about the ontology of globalisation. First, it interrogates the claim that the contemporary phenomenon of globalisation is underpinned by the theoretical construct of economic and information-epistemic determinism (EI-ED), which has been developmentally significant in the North. The paper contends that this claim is likely to propagate some values that ought not to undergird the end-state vision of the prospective global village (PGV) if the PGV is to be essentially conjunctive rather than essentially disjunctive. Second, the paper contends that if a cohesive and egalitarian PGV is truly the end-point of the philosophy of globalisation, then the African socio-cultural values of a relational understanding of the self and universal brotherhood ought to be globally recognised and emphasised by the North as fundamental to the realisation of the vision of the PGV. The paper seeks to illustrate that if properly applied to the globalising process, these cultural values are ontologically conjunctive in the sense that they have the potential to promote the building of a cohesive and egalitarian global village, since they tend to encourage acceptance and co-operation among the different peoples of the world.

Keywords
Africa, culture, determinism, globalisation, philosophy
Assessment of tropical cyclone-induced shoreline and riverbank changes at the Rufiji Delta using satellite remote sensing methods
Authors: Kai Kombo H. , Francis Julius , Shaghude Yohanna W. 
Published: August 2022

The study aimed at quantifying changes in shoreline and riverbanks caused by tropical cyclones (TCs) and associated rainfall in the Rufiji Delta, southern Tanzania. Long term changes of the shoreline and riverbanks were analysed using medium resolution (Landsat TM and ETM) satellite imagery (1991, 1997 and 2007), while short-term changes (2013 to 2014) were analysed using high resolution (Pleiades) satellite imagery. Delineation of the shoreline and riverbank changes were accomplished through the analysis of appropriate coloured image composites, Sobel filtering and maximum likelihood classification of land cover. Analysis of Landsat data showed a relatively higher magnitude of erosion between 1991 and 2007, followed by minor changes between 1997 and 2007. Simbauranga was the most severely eroding site, with an estimated magnitude of erosion of 83 to 100 m during the study period. The maximum magnitude of short-term changes of the riverbanks were estimated at about 31 m2. Apart from the erosion of the riverbanks, other changes were the conversion of water to vegetation covered areas (amounting to approximately 200 m2). Short-term shoreline changes were up to 206 m with higher magnitude of accretion (142 m) than erosion (-4 m). The study conclusively calls for further detailed research on shoreline and riverbank changes based on the impacts of TCs on land cover.
Anais do VI Congresso Nacional e II Internacional de Oncologia
Authors: Revista Unimontes Científica  
Published: August 2022

O VI Congresso Nacional e II Internacional de Oncologia da Associação Presente reinaugura o formato presencial em 2022, destacando os avanços no tratamento do câncer, a prevenção, a epidemiologia, a assistência interdisciplinar nos cuidados paliativos, além das inovações e tecnologias em saúde ressaltando os desafios no cuidado e os direitos dos pacientes através do advocacy.
Com o objetivo de levar o conhecimento e humanização na assistência entre os profissionais das diversas áreas da saúde, a Associação Presente, que neste ano celebra 18 anos, tem a honra de anunciar a inauguração do Hospice Jesuína Rosa Silva – um centro de Cuidados Paliativos que oferecerá cuidado integral a pacientes e familiares diante de uma doença grave que ameace a continuidade da vida, através da prevenção e do alívio do sofrimento humano, tratando a dor e outros problemas de natureza física, psicossocial e espiritual.
Trata-se de um evento de altíssimo nível científico, com endereço em Montes Claros – MG, no Portal de Evento. A abertura do Congresso que acontece no dia 25.08.2022, e seguirá por três dias e finalizando em 27 de Agosto de 2022.
Com o foco para a transformação, ineditismo, práticas clássicas ou tecnológicas, diversos serão os temas debatidos por renomados palestrantes nacionais e internacionais. Contaremos também com a exposição presencial e apresentação de trabalhos científicos selecionados pela Comissão Avaliadora, que serão publicados nos Anais do Evento, na Revista Unimontes Científica.
Essa sexta edição reunirá profissionais e acadêmicos de saúde como médicos, enfermeiros, psicólogos, dentistas, nutricionistas, fisioterapeutas, profissionais de educação física, entre outros, abordando temas acerca do câncer, trazendo sempre o foco para o doente e não para a doença. Com isso, os congressistas ganham tanto na mudança de práticas clínicas a partir do conhecimento científico difundido quanto no manejo humanizado, respeitando o que realmente importa para quem lhe confia o cuidado.
Trajetória histórica e protagonismos dos tupinambás no sul da Bahia:
Authors: Silva Ayalla Oliveira 
Published: August 2022

O sul da Bahia compreende uma região de extremo conflito de terras envolvendo diversos setores da sociedade regional e os povos indígenas habitantes dessa região, com destaque aos litígios em torno da demarcação da Terra Indígena Tupinambá de Olivença, em curso. Terra Indígena essa, reconhecida e delimitada pela agência indigenista (FUNAI), por meio do vínculo que os tupinambás de Olivença guardam com o aldeamento colonial Nossa Senhora da Escada, freguesia de Ilhéus, século XVII. O presente artigo tem por objetivo, portanto, apresentar e discutir a trajetória histórica dos tupinambás com os processos de territorialização, isto é, compreender na longa duração a relação deste Povo com os projetos colonial e de construção do Estado-nação, e os subsequentes processos de esbulhos e de lutas pela recuperação territorial. Para tanto, me utilizarei de fontes de natureza variada e da bibliografia ocupada em estudar os tupinambás de Olivença em diferentes contextos da sua trajetória histórica.
Palavras-chave: Tupinambás de Olivença. Territorialização. Terra Indígena. Demarcação.
Resolução de problemas do campo multiplicativo e surdez: uma revisão bibliográfica
Authors: Tavares Scarpelli Raquel , Segadas Vianna Claudia Coelho de , Pereira Madalena Silene 
Published: August 2022

Neste artigo, buscamos apresentar ao leitor o resultado de uma revisão bibliográfica sistematizada realizada a partir de artigos científicos nacionais e internacionais publicados no período de 1930 a 2019 sobre problemas matemáticos no campo multiplicativo no escopo do ensino e aprendizagem de surdos. A escolha por um período de 90 anos tem por objetivo averiguar a evolução dessa temática no meio acadêmico brasileiro e internacional ao longo do tempo. Nosso principal intuito foi o de buscar identificar que enfoques têm sido mais frequentes nesses artigos e observar se eles têm ou não se mantido constantes. Como critério de seleção dos periódicos, foram utilizadas buscas com palavras-chave específicas que façam uma combinação entre surdez e problemas do campo multiplicativo em plataformas online de pesquisas acadêmicas. Como resultado, obtivemos 12 artigos, dos quais emergiram três categorias: identificação de dificuldades dos alunos surdos em aritmética, análise do modo como os alunos surdos operacionalizam a multiplicação e práticas docentes em sala de aula no ensino de aritmética para alunos surdos.
Analysis That Influences The Quality Of Nursing Services In Installations Of Colonel Abunjani Hospital, Bangko In 2019
Authors: Abdi Eliezer Dakhi Juang , Lestari Ramadhani Nasution Sri , Girsang Ermi , Suryono Tan 
Published: August 2022

The implementation of hospital health services in Indonesia currently faces increasingly complex challenges. The improvement of hospital quality must be improved in accordance with the development of the needs and demands of the community, accompanied by an increase in efficiency and productivity in the field of management, in accordance with the hospital's minimum service standards, professional standards, and standard operating procedures. The study aims to determine the relationship of knowledge, skills, behavior, education, experience, and motivation of nurses with the quality of nursing services at the kolonel abunjani bangko Hospital in 2019. This observational analytic study uses a Cross Sectional design. Chi square statistical test and multiple logistic regression regression were used to analyze data. The population and sample size in this study were 92 nurses where data collection was taken from the results of the questionnaire. The results of the bivariate analysis showed that there was a relationship of knowledge, skills, behavior, potential, education, experience, and motivation with the quality of nursing services at the kolonel abunjani bangko Hospital in 2019. The results of multivariate analysis showed that experience was the most dominant variable affecting quality service. Conclusions obtained are the relationship of knowledge, skills, behavior, potential, education, experience, and motivation of nurses with the quality of nursing services in kolonel abunjani bangko Hospital in 2019. It is recommended to the hospital, to continue to improve knowledge, skills, behavior, education, experience, and continuous motivation. By increasing competence and continuous performance, the nurse's weaknesses and strengths can be known. Thus, good nurse competency can give satisfaction to patients and provide job promotion so as to improve the work performance of nurses so that they can increase the quality of health services.