bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Zinc Supplementation on some Biochemical and Hematological Parameters in Alloxan Induced Diabetic Rats
Authors: Dabirinejad Hakemeh , Dayer Mohammad Reza , Mohammadi Tayebeh 
Published: March 2022

Background & Objective: This study aims to evaluate the effects of zinc sulfate on blood biochemical and hematological parameters in healthy control and alloxan-induced diabetic rats.
Materials & Methods: Experimentally, 40 rats were used in four equal groups, including healthy control, healthy feed with zinc sulfate, diabetic control, and zinc sulfate. The alloxan 120 mg/kg with blood sugar over 140-250 mg / dL was intraperitoneally injected to induce diabetes mellitus. In addition, the value of 0.6 g / L zinc sulfate dissolved in tap water was used for three months to be drunk by the treated group. All animals were killed, and blood and pancreas samples were collected for necessary tests. Serum levels of alpha-amylase, total cholesterol, triglycerides, LDL, HDL, hemoglobin, and hematocrit were measured. Statistical data were analyzed based on the analysis of variance using SPSS software.
Results: Our data showed that in the diabetic control group, serum levels of total cholesterol, triglyceride, LDL increased significantly and hemoglobin, hematocrit, and HDL decreased significantly compared to the healthy control (P< 0.05). Zinc sulfate consumption in these groups reduces total cholesterol, triglyceride, LDL and increases hemoglobin and hematocrit compared to the control groups. Microscopic examination of the pancreas showed that in the diabetic control group, the percentage of Beta cells was reduced compared to the other groups.
Conclusion: Our findings reveal that dietary zinc sulfate not only exerts no damage to bodies but also zinc sulfate as food supplement seems to have beneficial effects on biochemical and hematological parameters in diabetic and healthy animals.
Using mobile phone applications in engaging nurses for preventing healthcare-associated infections: A systematic review
Authors: Fithriyyah Yayu Nidaul , Aulawi Khudazi 
Published: March 2022

Background & Aim: Prevention of healthcare-associated infections targets health workers. Considering the crucial role of nurses, potential applications of mobile phone-based interventions are innovative, attractive, and easily accessible. This study synthesizes mobile applications with the involvement of nurses or nursing students in outcomes to prevent healthcare-associated infections and their implications.
Methods & Materials: Systematic review, database searches included: SCOPUS, EBSCO MEDLINE, PubMed, ProQuest, Institute of Electrical and Electronics Engineers, and SagePUb. Population involved nurses or nursing students with mobile-based interventions about healthcare-associated infections. Quantitative design focused on publications between 2015-2021. Methodological quality applied the Cochrane and the National Heart, Lung, and Blood Institute tools. Analysis used narrative synthesis.
Results: 11 studies met inclusion criteria from 1,792. Study populations were heterogeneous. Mobile phone interventions included: short message service (18.2%), (9.1%), mobile and computer access (18.2%), and iOs/Android-based (27.3%). healthcare-associated infections prevention focused on: surgical site infections (54.5%), central line-associated bloodstream infections (9.1%), catheter-associated urinary tract infections (9.1%), antimicrobials (9.1%), knowledge, attitude, and practice towards healthcare-associated infections (18.2%). Most bias risks were moderate to high. Participants showed positive responses. All studies described problems in implementing healthcare-associated infections applications. Five studies reported estimated cost savings.
Conclusion: Using mobile phone applications has involved nurses as researchers, participants, and intervention providers to patients. The impact is promising in preventing healthcare-associated infections. Response of user is influenced by technology familiarity, which involves interactive features and problem anticipation. This review showed significant cost savings, so stakeholders and future research plans can consider it.
Liberdade de Imprensa em Moçambique: O caso de influência do poder politico no judiciário
Authors: Leonardo Sarmento Bacelar 
Published: March 2022

O artigo foca sobre o relacionamento entre o poder político e o poder judiciário nos casos de violação da liberdade de expressão e, sobretudo a de imprensa, em Moçambique. Apesar deste garantismo e pluralismo constitucional, no ordenamento moçambicano persistem formas directas e indirectas, de limitação da liberdade de expressão e de imprensa, mesmo de cunho jurídico. Para tanto, existe uma evidente diferenciação entre a actuação do Ministério Público e dos juízes de tribunal. A liberdade de opinião e expressão, incluindo a liberdade de “receber e difundir, sem consideração de fronteiras, informações e ideias por qualquer meio de expressão” é um dos direitos civis e políticos básicos, que se encontra formulado em todos os respectivos instrumentos de direitos humanos, quer da Declaração Universal dos Direitos Humanos de 1948 quer da Constituição da República de Moçambique. Mediante casos concretos de julgamentos feitos contra jornalistas, editores e proprietários de jornais em Moçambique, o artigo demonstra que a influência do poder político no judiciário ainda é considerável, embora nem sempre uniforme, mudando segundo o contexto (dentro ou fora de Maputo) e a situação política contingente.
Anemia and Its Associated Factors among Final-Year Medical Students at Sana'a University, Yemen
Authors: Mogahid Y. Nassar  , Ahmed S. Hudna  , Fatima Abdurubbu  , Aisha Mohammed  , Ala'a Maresh  , Fatima Mohammed  , Hadeer Al-ariqi  , Reem Al-maqtari  , Narmeen Al-ariqi  , Wafa'a Al-hammadi  
Published: March 2022

Objective: To determine the prevalence of anemia and its associated risk factors among final-year medical students at Sana'a University, Yemen.
Methods: This cross-sectional study was conducted among 269 final year students randomly selected from the medical faculties of Sana'a University in the period from January to April 2018. Data were collected using a structured questionnaire, while venous blood samples were collected by venipuncture into EDTA tubes. Hemoglobin (Hb) concentration was estimated using an automated hematology analyzer in the Laboratory Department of the University of Science and Technology in Sana’a city. Data were analyzed using appropriate statistical tests, and statistical significance was considered at P-values <0.05.
Results: The mean Hb concentration of final-year medical students at Sana’a University was 15.1 ± 1.9 g/dL. The mean Hb concentration for male students was 16.3 ± 1.5 g/dL, while the mean Hb concentration for female students was 13.1 ± 1.5 g/dL. Anemia was prevalent among 12 (4.5%) out of 269 medical students and was significantly associated with the gender and smoking status of the students, where females (OR = 5.9, 95% CI: 1.8–27.4; P = 0.011) and smokers (OR = 6.3, 95% CI: 1.2–3.7; P = 0.002) were about six times more likely to be anemic compared to their counterparts. In contrast, there was no statistically significant association between anemia and age, family size, family income, presence of chronic disease(s), khat chewing, exercise, or history of blood transfusion.
Conclusions: The prevalence of anemia among final-year medical students at Sana'a University is low compared to other studies elsewhere. The female gender and smoking are the risk factors significantly associated with anemia among medical students. Further large-scale studies among medical and non-medical students from different levels of study at public and private universities of the country are recommended.
Penentuan Cr (VI) and SO42- Menggunakan Spektrofotometri UV-Vis dalam Sampel Air Sungai di Dinas Lingkungan Hidup Kota Semarang
Authors: YANTI IKA 
Published: March 2022

Analisis Kromium heksavalen (Cr-VI) dan ion sulfat (SO42-) pada air sungai yang ada di lingkungan kota Semarang bertujuan untuk mengetahui kualitas air sungai yang dibandingkan dengan Peraturan Pemerintah Nomor 22 Tahun 2021. Konsentrasi Kromium (Cr-VI) ditentukan dengan menggunakan metode spektrofotometri dengan pereaksi 1,5-diphenylcarbazide dan dianalisis dengan spektrofotometer UV-Vis pada panjang gelombang 540 nm, sedangkan penentuan kadar kadar sulfat (SO42-) menggunakan metode turbidimetri menggunakan spektrofotometer yang sama pada panjang gelombang 420 nm. Hasil analisis pengujian didapatkan kadar Cr(VI) sebesar 0,0094 mg/L dan 0,0096 mg/L sedangkan kadar SO42- sebesar 17,2105 mg/L dan 20,6842 mg/L. Hasil tersebut menunjukkan bahwa air sungai berdasarkan PP Nomor 22 Tahun 2021 tentang baku mutu air sungai kelas II, kualitas air sungai masih baik dan dapat digunakan sesuai peruntukannya karena masih di bawah ambang batas maksimum kadar Cr(VI) dan SO42- yaitu berturut-turut 0,05 mg/L untuk kadar Cr(VI) dan 300 mg/L untuk kadar SO42-.
Development of Project Activities for Teachers and Students of the Education System
Authors: Chekhovska Liubov , Chernysh Natalia , Ravchyna Tetyana 
Published: March 2022

The main purpose of the article is to identify and analyze the main mechanisms for the development and improvement of project activities for teachers and students of the education system and a brief analysis of the content and structure and determination of an important condition for the development of pedagogical activities in connection with project activities. Changes in social life taking place in our time require the development of new methods of education, pedagogical technologies dealing with the individual development of the individual. It is necessary to develop students' ability to think independently, to acquire and apply knowledge. This is due to the introduction of methods and technologies into the educational process based on the design and research activities of students. To achieve this goal, it is necessary to highlight the essential attributes of activity, analyze various interpretations of project activities and concepts similar in content to it, determine the components of pedagogical activity, make a comparative analysis of pedagogical and project activities and prove that project activity is a condition for the development of pedagogical activity. As a result, the main mechanisms and techniques for the development and improvement of project activities for teachers and students of the education system were analyzed and investigated
Pandemic-Related Workplace Violence and Its Impact on Public Health Officials, March 2020‒January 2021
Authors: Ward Julie A. , Stone Elizabeth M. , Mui Paulani , Resnick Beth 
Published: March 2022

Objectives. To characterize the experience and impact of pandemic-related workplace violence in the form of harassment and threats against public health officials. Methods. We used a mixed methods approach, combining media content and a national survey of local health departments (LHDs) in the United States, to identify harassment against public health officials from March 2020 to January 2021. We compared media-portrayed experiences, survey-reported experiences, and publicly reported position departures. Results. At least 1499 harassment experiences were identified by LHD survey respondents, representing 57% of responding departments. We also identified 222 position departures by public health officials nationally, 36% alongside reports of harassment. Public health officials described experiencing structural and political undermining of their professional duties, marginalization of their expertise, social villainization, and disillusionment. Many affected leaders remain in their positions. Conclusions. Interventions to reduce undermining, ostracizing, and intimidating acts against health officials are needed for a sustainable public health system. We recommend training leaders to respond to political conflict, improving colleague support networks, providing trauma-informed worker support, investing in long-term public health staffing and infrastructure, and establishing workplace violence reporting systems and legal protections. (Am J Public Health. 2022;112(5):736–746. https://doi.org/10.2105/AJPH.2021.306649 )
Measure of Personal Network Size Using the Known Population Method: A Methodological Guide
Authors: Clay-Warner Jody , Kawashima Tenshi , Edgemon Timothy G. 
Published: March 2022

The network scale-up method (NSUM) has shown promise in measuring the prevalence of hidden public health problems and at-risk populations. The technique involves asking survey respondents how many people they know with the health problem or characteristic of interest and extrapolating this information to the population level. An important component of the NSUM estimate is the size of each respondent’s network, which is determined by asking respondents about the number of people they know who belong to populations of known size. There is little systematic discussion, however, to guide selection of these questions. Furthermore, many of the most commonly used known population questions are appropriate only in countries with a robust data infrastructure. Here, we draw from the NSUM literature to present a set of best practices in the selection of NSUM known population questions. Throughout, we address the unique situations that many researchers face in collecting prevalence data in the developing world, where innovative prevalence estimation techniques, such as NSUM, are most needed. (Am J Public Health. 2022;112(5):747–753. https://doi.org/10.2105/AJPH.2022.306731 )
Jujuboside A attenuates Sepsis‑induced Cardiomyopathy by inhibiting inflammation and regulating autophagy
Authors: Wang Zi , Ji Qingqi , Li Yanjie , Cai Zhaohua , Fang Liang , Huo Huanhuan , Zhou Guo , Yan Xiangming , Shen Linghong , He Ben 
Published: March 2022

Abstract
Background: Jujuboside A (JuA), as a main effective component of Jujubogenin, which was extracted from the seed of Ziziphus jujuba Mill, has long been known as a sedative-hypnotic drug. The aim of the current study was to investigate the potential effect of JuA on sepsis-induced cardiomyopathy (SIC) induced by lipopolysaccharide (LPS) in mouse models. Method: Wide type C57BL/6J mice were randomly divided into four groups: ddH2O+control, ddH2O+JuA, LPS+NS and LPS +JuA, and the cardiac function of septic mice were detected by echocardiography. Moreover, the survival rate at each time point was calculated for 7 days. ELISA assays were used to analyze inflammatory factors in serum. Furthermore, Western blotting, flow cytometry and TUNEL staining were performed to assess cell apoptosis and transmission electron microscopy detecting the number of autophagosomes. Finally, the expression of autophagy-related and oxidative stress-related proteins was analyzed by western blotting and immunohistochemistry staining. Results: Results showed that JuA pretreatment significantly improved the survival rate and cardiac function, and suppressed systemic inflammatory response in septic mice. Further study revealed that JuA could decrease cell apoptosis and enhanced autophagy. Moreover, JuA pretreatment also significantly decreased oxidative stress and nitrodative stress, as evidenced by downregulating iNOS and gp91 expression in vivo. In addition, the autophagy inhibitor 3‑MA significantly abolished the effect of JuA on autophagic activity in SIC. Conclusion: In conclusion, the findings indicated that JuA enhanced autophagy blocking inflammasome-mediated cardiomyocyte apoptosis and suppress myocardial iNOS and gp91 expression to improve cardiac function of SIC in septic mice.
Performance Analysis of Humidity Tapered Optical Fiber Sensor
Authors: de Carvalho Pedro Vitor Taranto , Martinez Maria Aparecida Gonçalves , Giraldi Maria Rocco 
Published: March 2022

Abstract
Among different interferometric fiber optic sensors a Relative Humidity sensor based on a singlemode-no-core-singlemode tapered fiber structure is proposed. The mathematical model of the interferometer structure is developed, simulated and validated as a refractive index sensor. Different materials for coating the No-core fiber section are analyzed for better Relative Humidity sensitivity. Agarose, Porous Silica and SiO2 nanoparticles were selected as coating materials for Pure Silica and dPMMA fibers. The d-PMMA fiber with Agarose coating presents the highest average sensitivity of 533.46pm/RH% in the 0-60% RH range, when the tapered section has zero length. Furthermore, variations in the dimensions of the structure are explored showing that we can tune the sensitivity according to the tapered length and radius. An extension of the tapered section up to 4000µm gives an improvement of 227% in the average sensitivity. Moreover, a reduction of the tapered radius from 15µm to 1.5µm gives an rise in the sensitivity of 295%.
Formability investigation of 6061-T6 aluminum alloy sheet at elevated temperatures
Authors: Safdarian Rasoul 
Published: March 2022

Abstract
Aluminum alloy sheets are widely used in different industries that the main reason is the high strength to weight ratio of these sheets. Among these sheets, the 6061-aluminum alloy (AA 6061) is more useable in automotive and aircraft industries, because of its high strength and more formability properties which have rather than most aluminum alloy sheets. Although AA 6061 sheet has more formability compare to most other aluminum alloy sheets, still it has low formability at room temperature which is one of its drawbacks. Therefore, in the present study, the formability of AA 6061-T6 sheets with thickness of 2 mm is investigated at different temperatures in the range of room temperature (RT) to 300℃. For this purpose, the experimental tests of forming limit diagram (FLD) are done at different temperatures by using the non-isothermal Nakajima standard die based on the ISO 12004-2 standard. The FLD tests are done with no lubrication in the sheet and punch contact at different temperatures. The results indicated that the FLD level and formability increased by temperature increase from RT to 100℃ and then decreased by temperature increase from 200℃ to 300℃. Results showed that happening of adhesive wear between the punch and the sheet surface is the main factor that restricted the material flow and deformation of sheet when the temperature is more than 100℃. The higher temperature which is used in the forming process, the stronger adhesive wear will happen.
Temperature and Oxygen Response to Groundwater Discharge in the Ice-Covered Razdolnaya River Estuary (Sea of Japan)
Authors: Semkin Pavel , Tishchenko Pavel , Charkin Alexander , Pavlova Galina , Anisimova Ekaterina , Barabanshchikov Yuri , Mikhailik Tatyana , Tishchenko Petr 
Published: March 2022

Abstract
The study demonstrates a dynamic connection between the saltwater wedge region and its underlying aquifer. In winter, this estuary is covered with ice and the river flow is at its lowest; that is why its hydrological and oxygen-specific response to groundwater discharge is best marked in this season. Groundwater discharge was detected in the saltwater wedge region by highly active radium isotopes: 224Ra — 66.32 ± 0.60 dpm 100L−1, 223Ra — 2.85 ± 0.17 dpm 100L−1, 228Ra — 159.15 ± 0.13 dpm 100L− 1. The temperature of ground and river waters was +4.3 °С and +0.09 °С, respectively, that of sea water −1.2 °С, and the near-bottom layer temperature increased up to +1.2 °С in the water discharge region. According to the data provided by an anchored autonomous station installed in the area of saltwater discharge influence during the freeze-up period, the temperature reaches 2.5 °С in the saltwater wedge. Groundwater discharge is accompanied by a lower level of oxygen saturation – 67%, at that time oxygen saturation in sea water was 151%. Thus, we present evidence documenting the natural process that may result in a lower level of oxygen saturation in an estuary irrespective of man-induced effects, supply of nutrients and further intensification of production-destruction processes.
The Genomic and Immunologic Signature of VISTA Based on a Pan-cancer Analysis
Authors: Cao Xi , Zhou Xingtong , Sun Qiang 
Published: March 2022

Abstract
The V-domain immunoglobulin suppressor of T cell activation (VISTA) is thought to be a non-redundant T cell regulation checkpoint of the PD-1/PD-L1 axis. VISTA has recently emerged as an anti-tumor immunotherapy agent. To understand the genomic and immunological signatures of VISTA, we evaluated its expression levels, prognostic effects, mutation and copy number alterations, and immune infiltration signatures by pan-cancer analysis via multiple public datasets. Relative to normal tissues, tumour tissues frequently exhibit VISTA downregulation. Survival and immune infiltration signature analyses indicated that VISTA expression was differently correlated with outcome and immune infiltration level among various cancer types. Nevertheless, VISTA upregulation increased the survival and immune infiltration levels in breast, lung, and skin cancers but did not markedly improve survival and was only weakly correlated with the immune infiltration level in ovarian cancer. The VISTA pan-cancer mutation rate was almost 2%. The major mutation type was missense, followed by synonymous substitution with C>T. Functional annotation and pathway enrichment analyses revealed that VISTA-related genes and proteins participated in the T cell and Toll-like receptor signalling pathways, innate immune and inflammatory responses, and negative regulation of NF-κB transcription and interleukins. The foregoing results may help clarify the mechanism of VISTA in tumour immune response.
Mapping the conformational landscape of the stimulatory heterotrimeric G protein
Authors: Prosser Robert , Huang Shuya , Rahmatullah Rima , Pandey Aditya , Eps Ned Van , Sunahara Roger , Ernst Oliver , Sljoka Adnan 
Published: March 2022

Abstract
Heterotrimeric G proteins serve as key membrane-associated signaling hubs, in concert with their cognate G protein-coupled receptors (GPCRs). Using site-directed labels located at four key allosteric sites within the Ras-homology domain of the stimulatory G protein α-subunit, Gsα, fluorine nuclear magnetic resonance spectroscopy (19F NMR) was employed to monitor the conformational equilibria of Gsα by itself, in the intact Gsαβγ heterotrimer, or in complex with either membrane alone or membrane-embedded adenosine A2A receptor (A2AR). The results reveal a concerted equilibrium which is strongly affected by nucleotide and interactions with the βγ-subunit, the lipid bilayer, and A2AR. 19F NMR spectra of the α1 helix of Gsα exhibit significant intermediate timescale dynamics, while those associated with the α4β6 loop and the α5 helix reflect respective membrane/receptor interactions and order/disorder transitions associated with G protein activation. The αN helix adopts a key functional state that serves as an allosteric conduit between the βγ-subunit and the receptor, while spectra in the presence of GTPγS reveal that a significant fraction of the ensemble remains tethered to the membrane and the receptor upon activation.