bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Parkinson disease related genes based on PyFeat and gradient boosted decision tree
Authors: Helmy Marwa , Eldaydamony Eman , Mekky Nagham , Elmogy Mohammed , Soliman Hassan 
Published: June 2022

AbstractIdentifying genes related to Parkinson’s disease (PD) is an active research topic in biomedical analysis, which plays a critical role in diagnosis and treatment. Recently, many studies have proposed different techniques for predicting disease-related genes. However, a few of these techniques are designed or developed for PD gene prediction. Most of these PD techniques are developed to identify only protein genes and discard long noncoding (lncRNA) genes, which play an essential role in biological processes and the transformation and development of diseases. This paper proposes a novel prediction system to identify protein and lncRNA genes related to PD that can aid in an early diagnosis. First, we preprocessed the genes into DNA FASTA sequences from the University of California Santa Cruz (UCSC) genome browser and removed the redundancies. Second, we extracted some significant features of DNA FASTA sequences using the PyFeat method with the AdaBoost as feature selection. These selected features achieved promising results compared with extracted features from some state-of-the-art feature extraction techniques. Finally, the features were fed to the gradient-boosted decision tree (GBDT) to diagnose different tested cases. Seven performance metrics were used to evaluate the performance of the proposed system. The proposed system achieved an average accuracy of 78.6%, the area under the curve equals 84.5%, the area under precision-recall (AUPR) equals 85.3%, F1-score equals 78.3%, Matthews correlation coefficient (MCC) equals 0.575, sensitivity (SEN) equals 77.1%, and specificity (SPC) equals 80.2%. The experiments demonstrate promising results compared with other systems. The predicted top-rank protein and lncRNA genes are verified based on a literature review.
Elevated light intensity compensates for nitrogen deficiency during chrysanthemum growth by improving water and nitrogen use efficiency
Authors: Esmaeili Sara , Aliniaeifard Sasan , Dianati Daylami Shirin , Karimi Soheil , Shomali Aida , Didaran Fardad , Telesiński Arkadiusz , Sierka Edyta , Kalaji Hazem M. 
Published: June 2022

AbstractIdentifying environmental factors that improve plant growth and development under nitrogen (N) constraint is essential for sustainable greenhouse production. In the present study, the role of light intensity and N concentrations on the biomass partitioning and physiology of chrysanthemum was investigated. Four light intensities [75, 150, 300, and 600 µmol m−2 s−1photosynthetic photon flux density (PPFD)] and three N concentrations (5, 10, and 15 mM N L−1) were used. Vegetative and generative growth traits were improved by increase in PPFD and N concentration. High N supply reduced stomatal size and gsin plants under lowest PPFD. Under low PPFD, the share of biomass allocated to leaves and stem was higher than that of flower and roots while in plants grown under high PPFD, the share of biomass allocated to flower and root outweighed that of allocated to leaves and stem. As well, positive effects of high PPFD on chlorophyll content, photosynthesis, water use efficiency (WUE), Nitrogen use efficiency (NUE) were observed in N-deficient plants. Furthermore, photosynthetic functionality improved by raise in PPFD. In conclusion, high PPFD reduced the adverse effects of N deficiency by improving photosynthesis and stomatal functionality, NUE, WUE, and directing biomass partitioning toward the floral organs.
Nationwide population-based incidence of cancer among patients with HIV/AIDS in South Korea
Authors: Lee Soon Ok , Lee Jeong Eun , Lee Shinwon , Lee Sun Hee , Kang Jin Suk , Son Hyunjin , Lee Hyungi , Kim Jinmi 
Published: June 2022

AbstractCancers are the leading cause of death among people living with HIV/AIDS (PLWHA); however, nationwide studies on cancer incidence are limited. We aimed to determine the trends in the incidence rates of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) among Korean PLWHA. Data from the National Health Insurance Sharing Service from 2004 to 2017 were collected. Age- and sex-adjusted standardized incidence ratios (SIRs) for various cancer types relative to the general population were calculated. Of the 11,737 PLWHA followed-up for 65,052 person-years (PYs), 445 (ADCs, 130 and NADCs, 298) developed cancer. The incidence rate of ADCs decreased, whereas that of NADCs remained unchanged. PLWHA were at an increased risk of ADCs (SIR: 12.6, 95% CI: 10.6–15.0), including Kaposi’s sarcoma, non-Hodgkin’s lymphoma, and cervical cancer, and some NADCs, including anal cancer, lung cancer, liver cancer, and oropharyngeal cancer. Of the 396 patients who received antiretroviral therapy (ART), 215 with optimal adherence had lower incidence rates for ADCs and NADCs than those with non-optimal adherence. The 5-year survival rate of PLWHA with NADCs was 57.8%. Close surveillance and routine screening of cancers and improvement in ART adherence are required to improve the clinical outcomes of PLWHA.
A new human-based metaheuristic algorithm for solving optimization problems on the base of simulation of driving training process
Authors: Dehghani Mohammad , Trojovská Eva , Trojovský Pavel 
Published: June 2022

AbstractIn this paper, a new stochastic optimization algorithm is introduced, called Driving Training-Based Optimization (DTBO), which mimics the human activity of driving training. The fundamental inspiration behind the DTBO design is the learning process to drive in the driving school and the training of the driving instructor. DTBO is mathematically modeled in three phases: (1) training by the driving instructor, (2) patterning of students from instructor skills, and (3) practice. The performance of DTBO in optimization is evaluated on a set of 53 standard objective functions of unimodal, high-dimensional multimodal, fixed-dimensional multimodal, and IEEE CEC2017 test functions types. The optimization results show that DTBO has been able to provide appropriate solutions to optimization problems by maintaining a proper balance between exploration and exploitation. The performance quality of DTBO is compared with the results of 11 well-known algorithms. The simulation results show that DTBO performs better compared to 11 competitor algorithms and is more efficient in optimization applications.
Running interval training combined with blood flow restriction increases maximal running performance and muscular fitness in male runners
Authors: Chen Yun-Tsung , Hsieh Yao-Yi , Ho Jen-Yu , Ho Chien-Chang , Lin Tung-Yi , Lin Jung-Charng 
Published: June 2022

AbstractWe investigated the effects of 8 weeks (3 days per week) of running interval training (RIT) combined with blood flow restriction (RIT-BFR) on the maximal running performance (RPmax), isokinetic muscle strength, and muscle endurance in athletes. Twenty endurance-trained male runners were pair-matched and randomly assigned to the RIT-BFR and RIT groups. The RIT-BFR group performed RIT (50% heart rate reserve, 5 sets of 3 min each, and 1-min rest interval) with inflatable cuffs (1.3× resting systolic blood pressure), and the RIT group performed the same RIT without inflatable cuffs. RPmax, isokinetic muscle strength, and muscle endurance were assessed at pre-, mid-, and post-training. Compared with the RIT group, the RIT-BFR group exhibited a significantly (p < 0.05) greater increase in RPmax, isokinetic knee extensor and flexor strength, and knee extensor endurance after 24 training sessions. These results suggested that RIT-BFR may be a feasible training strategy for improving muscular fitness and endurance running performance in distance runners.
Dispersal and oviposition patterns of Lycorma delicatula (Hemiptera: Fulgoridae) during the oviposition period in Ailanthus altissima (Simaroubaceae)
Authors: Jung Minhyung , Kho Jung-Wook , Gook Do-Hun , Lee Young Su , Lee Doo-Hyung 
Published: June 2022

AbstractThe spotted lanternfly (SLF), Lycorma delicatula (Hemiptera: Fulgoridae), has the potential to become a global pest and is currently expanding its range in the United States. In this study, we investigated the dispersal patterns of SLF in Ailanthus altissima during its oviposition period in South Korea using a fluorescent marking system. Oviposition patterns of SLF were then analyzed by surveying egg masses in A. altissima patches. The recapture rate of fluorescent-marked SLF rapidly decreased to 30% within the first two weeks. During the oviposition period, seven cases of among-patch dispersal of SLF adults were observed. The minimum distance that SLF could have traveled to achieve these among-patch dispersal events ranged from 10 to 1740 m, with most events spanning under 60 m. Also, the number of A. altissima trees on which fluorescent marked SLF were detected increased until September. Based on the egg mass survey, a total of 159 egg masses were detected from 38 out of 247 A. altissima trees. Furthermore, 79.2% of egg masses were located < 2.5 m above the ground. Finally, a generalized linear mixed model showed that tree height and diameter at root collar (DRC) of A. altissima trees had significant effects on the number of egg masses.
Aging in magma rheology
Authors: Kurokawa Aika K. , Miwa Takahiro , Ishibashi Hidemi 
Published: June 2022

AbstractAging, change in property depending on the elapsed time from preparation, is known to affect the rheological behavior of various materials. Therefore, whether magma ages must be examined to characterize potentially widespread volcanic phenomena related to the transition from rest to flow. To achieve this, we performed rheological measurements and microstructural analyses on basaltic andesite lava from the 1986 Izu-Oshima eruption. The rheology shows an initial overshoot of shear stress during start-up flow that correlates with the duration and the shear rate of a pre-rest time. This indicates that the yield stress of magma and lava increases with aging. The microstructure shows that original aggregates of crystals, which may grow during crystallization, coalesce during the pre-rest period to form clusters without changing the crystal volume fraction. We conclude that the clusters are broken by shear in the start-up flow, which induces the stress overshoot. Thus, aging in magma rheology will impact the understanding of dynamic flow.
Usability of deep learning and H&E images predict disease outcome-emerging tool to optimize clinical trials
Authors: Qaiser Talha , Lee Ching-Yi , Vandenberghe Michel , Yeh Joe , Gavrielides Marios A. , Hipp Jason , Scott Marietta , Reischl Joachim 
Published: June 2022

AbstractUnderstanding factors that impact prognosis for cancer patients have high clinical relevance for treatment decisions and monitoring of the disease outcome. Advances in artificial intelligence (AI) and digital pathology offer an exciting opportunity to capitalize on the use of whole slide images (WSIs) of hematoxylin and eosin (H&E) stained tumor tissue for objective prognosis and prediction of response to targeted therapies. AI models often require hand-delineated annotations for effective training which may not be readily available for larger data sets. In this study, we investigated whether AI models can be trained without region-level annotations and solely on patient-level survival data. We present a weakly supervised survival convolutional neural network (WSS-CNN) approach equipped with a visual attention mechanism for predicting overall survival. The inclusion of visual attention provides insights into regions of the tumor microenvironment with the pathological interpretation which may improve our understanding of the disease pathomechanism. We performed this analysis on two independent, multi-center patient data sets of lung (which is publicly available data) and bladder urothelial carcinoma. We perform univariable and multivariable analysis and show that WSS-CNN features are prognostic of overall survival in both tumor indications. The presented results highlight the significance of computational pathology algorithms for predicting prognosis using H&E stained images alone and underpin the use of computational methods to improve the efficiency of clinical trial studies.
Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes
Authors: Muhia Mary , YuanXiang PingAn , Sedlacik Jan , Schwarz Jürgen R. , Heisler Frank F. , Gromova Kira V. , Thies Edda , Breiden Petra , Pechmann Yvonne , Kreutz Michael R. , Kneussel Matthias 
Published: June 2022

AbstractMuskelin (Mkln1) is implicated in neuronal function, regulating plasma membrane receptor trafficking. However, its influence on intrinsic brain activity and corresponding behavioral processes remains unclear. Here we show that murine Mkln1 knockout causes non-habituating locomotor activity, increased exploratory drive, and decreased locomotor response to amphetamine. Muskelin deficiency impairs social novelty detection while promoting the retention of spatial reference memory and fear extinction recall. This is strongly mirrored in either weaker or stronger resting-state functional connectivity between critical circuits mediating locomotor exploration and cognition. We show that Mkln1 deletion alters dendrite branching and spine structure, coinciding with enhanced AMPAR-mediated synaptic transmission but selective impairment in synaptic potentiation maintenance. We identify muskelin at excitatory synapses and highlight its role in regulating dendritic spine actin stability. Our findings point to aberrant spine actin modulation and changes in glutamatergic synaptic function as critical mechanisms that contribute to the neurobehavioral phenotype arising from Mkln1 ablation.
Transmission of antibiotic resistance at the wildlife-livestock interface
Authors: Lee Shinyoung , Fan Peixin , Liu Ting , Yang Anni , Boughton Raoul K. , Pepin Kim M. , Miller Ryan S. , Jeong Kwangcheol Casey 
Published: June 2022

AbstractAntibiotic-resistant microorganisms (ARMs) are widespread in natural environments, animals (wildlife and livestock), and humans, which has reduced our capacity to control life threatening infectious disease. Yet, little is known about their transmission pathways, especially at the wildlife-livestock interface. This study investigated the potential transmission of ARMs and antibiotic resistance genes (ARGs) between cattle and wildlife by comparing gut microbiota and ARG profiles of feral swine (Sus scrofa), coyotes (Canis latrans), cattle (Bos taurus), and environmental microbiota. Unexpectedly, wild animals harbored more abundant ARMs and ARGs compared to grazing cattle. Gut microbiota of cattle was significantly more similar to that of feral swine captured within the cattle grazing area where the home range of both species overlapped substantially. In addition, ARMs against medically important antibiotics were more prevalent in wildlife than grazing cattle, suggesting that wildlife could be a source of ARMs colonization in livestock.
Personalisierte Resektionsverfahren bei neuroendokrinen Neoplasien des Pankreas
Authors: Bösch Florian , Ghadimi Michael , Angele Martin K. 
Published: June 2022

ZusammenfassungNeuroendokrine Neoplasien des Pankreas (pNEN) haben eine steigende Inzidenz und erhalten klinisch dadurch eine immer höhere Relevanz. Neben den hormonell inaktiven pNEN gibt es die
hormonproduzierenden Tumoren, und sowohl die inaktiven als auch die aktiven pNEN können entweder sporadisch oder hereditär vorkommen. Die Behandlung orientiert sich an tumorassoziierten
Faktoren, aber auch an individuellen patienteneigenen Gegebenheiten. Für die Behandlung sind individuelle maßgeschneiderte Konzepte notwendig, welche die jeweiligen Faktoren und
Gegebenheiten berücksichtigen.
Hyperacute in-Stent Thrombosis Causing Large Vessel Occlusion after Stent-Assisted Aneurysm Coiling Secondary to Complete Clopidogrel and Prasugrel Resistance: a Case Report
Authors: Xian Elissa , Morrison Thomas , Wong Johnny 
Published: June 2022

AbstractDual antiplatelet therapy (DAPT) is standard treatment for endoluminal stent insertion, and complete resistance to DAPT is rare. A case of in-stent thrombosis occurring 3 hours after stent-assisted coiling of internal carotid artery aneurysm is presented despite compliance with DAPT. Platelet function tests (PFTs) revealed complete clopidogrel and prasugrel resistance.
Clinical Trial Combining Botulinum Toxin A Injection and Fissurectomy for Chronic Anal Fissure: A Dose-Dependent Study
Authors: Alsaleh Nuha , Aljunaydil Abdullah I. , Aljamili Gaida A. 
Published: June 2022

Abstract
Background Anal fissure is a common surgical disease that is usually treated conservatively. The golden surgical treatment for anal fissure is lateral internal sphincterotomy, but it may result in multiple complications. Therefore, other treatment methods have recently been introduced, and one of them is the injection of botulinum toxin A (BTA) and fissurectomy. In the present study, we aim to evaluate the effectiveness of the combination of fissurectomy and BTA injection in the treatment of chronic anal fissure by single surgeon.
Materials and Methods The present is a non-randomized prospective cohort study conducted by a single surgeon in Saudi Arabia. Our sample was composed of 116 female patients, with mean age of 36.57 ±  11.52 years, who presented to our Surgical Outpatient Clinic with chronic anal fissure between October 2015 and July 2020, and were treated with BTA injection combined with fissurectomy. They were followed up for 1, 2, 3, 4, and 8 weeks, and after one year to evaluate the efficacy and safety of the treatment. The main outcomes analyzed were symptomatic relief, complications, recurrence, and the need for further surgical intervention.
Results The treatment with BTA injection combined with fissurectomy was effective and safe in 115 patients (99.1%) at 1 year of follow-up. A total of 5 patients experienced recurrence at 8 weeks, which resolved completely with pharmacological sphincterotomy, and 12 patients experienced minor incontinence, which disappeared later.
Conclusion In total, 70 units of BTA injection combined with fissurectomy is a suitable second-line treatment of choice for chronic anal fissure, with a high degree of success and a low rate of major morbidity.
Survey on the use of general practice telehealth services for children during the COVID-19 pandemic
Authors: Ramanathan Ashwin , Ramanathan Paddy , Saha Amit 
Published: June 2022

In 2020, the Australian Government introduced temporary Medicare Benefits Schedule item numbers for GP telehealth consultations to combat the spread of the COVID-19 pandemic. Patient satisfaction has been positive; however, the paediatric cohort has not been sufficiently investigated. We aimed to explore the rates of satisfaction of paediatric patients undergoing telehealth compared with standard consultations, as well as looking at any barriers faced. We developed and distributed an online survey to eligible patients (or their guardian) aged 0–17 years who underwent a general practice telehealth consultation between March 2020 and May 2020 at 12 participating medical centres in Perth. We received 68 total responses with 35 deemed complete. The mean (s.d.) age of participants was 8.22 (5.34) years. A total of 88.2% of participants indicated that the level of care provided via telehealth was equal to or better than a standard consultation. A total of 70.6% of patients reported no barriers faced, with the most common barrier being lack of examination (20.6%). This study describes high public satisfaction with telehealth GP consultations for paediatric patients, with a good level of patient outcomes and minimal barriers. There may be benefit to widespread and ongoing use of telehealth consultations for the paediatric population and the extension of the temporary Medicare Benefits Schedule items.
Tone-fidelity for enrichment – Herder’s translation theory and practices
Authors: Pang Wenwei , Zhao Jiafeng 
Published: June 2022

Abstract
The famous German thinker Johann Gottfried Herder (1744–1803) has insightful thought of translation. According to
Herder’s exposition of the historicity of human language, the German language is in the adult phase. It can be enriched by
translating from more sensuous languages. In order to achieve the enrichment, Herder advocates an accommodating translation
approach with tone-fidelity. The translator must catch the tone of the original and be able to enable the tone-fidelity when
translating. Herder’s folk song collections are regarded as one of his great translations. An important part of them is the
translation practices of Shakespeare’s plays. Through the translation with faithfulness to the tone, Herder tries to enrich the
German language and literature, which is why he is regarded as a brilliant innovator and initiator of literary translation.
The effects of different narrative structures in public service announcements on transportation and counterarguing
Authors: Siegenthaler Perina , Fahr Andreas , Ort Alexander 
Published: June 2022

Abstract
Narratives are an effective way of presenting persuasive health communication because audience members can be transported into the story plot, which is shown to reduce various types of resistance. Using a laboratory experiment (N = 144), this study examined the effects of different narrative structures on transportation and counterarguing. Results suggest that a narrative presenting events in chronological order increases transportation in the case of people who are not affected by the health issue addressed in the communication, and that transportation reduces counterarguing. The study also found that such narratives increase counterarguing in general.
Field-free reliable magnetization switching in a three-terminal perpendicular magnetic tunnel junction via spin-orbit torque, spin-transfer torque, and voltage-controlled magnetic anisotropy
Authors: Yoshida Chikako , Tanaka Tomohiro , Ataka Tadashi , Hoshina Minoru , Furuya Atsushi 
Published: June 2022

Abstract
Magnetic field-free switching of a three-terminal perpendicular magnetic tunnel junction driven by spin-orbit torque (SOT) and spin-transfer torque (STT) in the presence of a voltage-controlled magnetic anisotropy (VCMA) effect was investigated using micromagnetic simulation at 300 K. The VCMA effect assists or hinders magnetization switching depending on the polarity of the applied voltage. Thus, the impact of these effects on switching probabilities was evaluated using two write voltage pulses (V
SOT, V
STT). By optimizing the configuration of these voltage pulses, we demonstrated 100 successful switchings out of 100 trials within 3.2 ns under a limit voltage of 1.0 V. In addition, the write power consumption for SOT-STT writing with optimal pulse configurations was found to be one order of magnitude lower than that of STT-alone writing. We also found that the SOT-STT writing has the great potential in practical use compared with the external magnetic field assisted SOT-writing. Field-free, reliable, and deterministic SOT-STT switching with low power consumption offers significant advantages for embedded memory applications.