bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytotoxic ent‐Kaurane Diterpenoids from Rabdosia Rubescens
Authors: Wei Wen‐Jun , Zhu Bingqiang , Si Yanpo , Guo Tao , Kang Jihong , Dai Liping 
Published: September 2022

AbstractOne new (1) and 11 reported ent‐kaurane diterpenoids (2–12) were received from the ethanol extract of the air‐dried aerial parts of Rabdosia rubescens collected in Jiyuan. Their structures were determined in accordance with high resolution electrospray ionization mass spectroscopy, one dimensional (1D) and two‐dimensional (2D) NMR spectroscopy and the data published in the literature. The cytotoxic activity of these isolated compounds was assessed against SMMC‐7721, A‐549, H‐1299 and SW‐480 cancer cell lines. Compounds 2–6 revealed significant cytotoxic activity on lung cancer cell lines A549 with IC50 values from 6.2 to 28.1 μM. Analysis of structure−activity relationship of these tested compounds indicated the carbonyl at C‐15 and hydroxy at C‐1 together could be crucial groups for inhibiting lung cancer cell lines A549 proliferation.
Transcriptional activation of hepcidin by the microphthalmia/transcription factor E family
Authors: Matsumura Manami , Murakami Masaru , Funaba Masayuki 
Published: September 2022

AbstractHepcidin negatively regulates the circulating iron levels by inhibiting the intestinal absorption of iron as well as iron release from macrophages. Hepcidin activity is largely determined by its expression, which is regulated at the transcriptional level. Hepcidin transcription is induced not only by the iron status‐related bone morphogenetic protein (BMP)‐2/6, but also by inflammatory cytokines, such as interleukin (IL)‐1β and IL‐6. The present study reveals that the microphthalmia (MiT)/transcription factor E (TFE) family members are novel regulators of hepcidin transcription. Melanocyte‐inducing transcription factor (MITF)‐A, a member of the MiT/TFE family, was identified as a positive regulator of hepcidin transcription via stimulus screening for transcription regulators. An E‐box (5′‐CATGTG‐3′) spanning nt‐645 to nt‐640 of the murine hepcidin promoter was identified as an MITF‐A‐responsive element. Responsiveness to MITF‐A on hepcidin transcription decreased when the cells were stimulated with BMP2 or IL‐1β. These results suggest a functional interaction between the MITF pathway and BMP‐ or IL‐1β‐mediated signaling. TFEB and TFE3, members of the MiT/TFE family, also stimulated hepcidin transcription, but the main region responsible for hepcidin transcription was distinct from that induced by MITF‐A. The region spanning nt‐581 to nt‐526 was involved in TFEB/TFE3‐mediated hepcidin transcription. Considering that members of the MiT/TFE family act as regulators of starvation‐induced lysosomal biogenesis, hepcidin expression may be controlled by additional pathways apart from those identified so far.
DNA‐Mediated Control of Protein Function in Semi‐Synthetic Systems
Authors: Snider Dylan M. , Pandit Subrata , Coffin Mackenzie L. , Ebrahimi Sasha B. , Samanta Devleena 
Published: September 2022

AbstractThe development of strategies for controlling protein function in a precise and predictable manner has the potential to revolutionize catalysis, diagnostics, and medicine. In this regard, the use of DNA has emerged as a powerful approach for modulating protein activity. The programmable nature of DNA allows for constructing sophisticated architectures wherein proteins can be placed with control over position, orientation, and stoichiometry. This ability is especially useful considering that the properties of proteins can be influenced by their local environment or their proximity to other functional molecules. Here, we chronicle the different strategies that have been developed to interface DNA with proteins in semi‐synthetic systems. We further delineate the unique applications unlocked by the unprecedented level of structural control that DNA affords. We end by outlining outstanding challenges in the area and discuss future research directions towards potential solutions.
Microkinetic Barriers of the Oxygen Evolution on the Oxides of Iridium, Ruthenium and their Binary Mixtures
Authors: Geppert Janis , Röse Philipp , Pauer Swantje , Krewer Ulrike 
Published: September 2022

AbstractThe performance of electrocatalytic water splitting in polymer electrolyte membrane electrolysis is substantially determined by the microkinetic processes of the oxygen evolution reaction (OER). Even highly active catalysts such as the nanoparticulated transition metal oxides IrO2, RuO2 and their mixtures, IrxRu1−xO2, exhibit overpotentials up to several hundreds of millivolts. The surface of the oxide mixtures IrxRu1−xO2 is found to consist of actives sites of both Ir and Ru on which the OER mechanism is processed independently and at different overpotentials. By applying microkinetic modelling and parameterization via cyclic voltammograms we show that there is a correlation between performance and the relative Ir content, that can be explained by two different deprotonation steps. These are in particular the formation of the adsorbate species *OOH on rutile RuO2 and *OO on IrO2. The respective free reaction energies are quantified to 1.44 eV and 1.58 eV, which are the highest values of the process and thus determining the overpotential. The additional finding of adsorbed oxygen *O covering >40 % of the active sites during the OER suggests that subsequent water adsorption is the major performance limiting step. Finally, a synergetic effect between both active sites on the binary transition metal oxides is identified: the respective other metal lowers the potential determining reaction energy on the Ru or Ir active site. This insight into the surface processes on Ir and Ru binary oxides forms the basis for deeper understanding of the active sites for further OER catalyst development.
Optimised Ni3+/Ni2+ and Mn3+/Mn2+ Ratios in Nickel Manganese Layered Double Hydroxide for Boosting Oxygen and Hydrogen Evolution Reactions
Authors: Duraivel Malarkodi , Nagappan Saravanan , Park Kang Hyun , Prabakar Kandasamy 
Published: September 2022

AbstractNiMn layered double hydroxide (LDH) grown hydrothermally on nickel foam substrate for water splitting application is reported. The Ni3+/Ni2+ and Mn3+/Mn2+ ratios are tuned to boost oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) active sites. The best‐optimized half‐cells with NiMn of 0.05 M (OER) and 0.025 M (HER) have the lowest overpotential, but a full‐cell fabricated from them has a higher cell voltage (1.68 V) than a symmetric cell made from 0.1 M NiMn LDH (1.56 V) at 10 mA cm−2. It is found that the best half cells made from NiMn of 0.05 M (OER) and 0.025 M (HER) have higher series and charge transfer resistance on the HER and OER side, respectively. The calculated specific activity and turnover frequency normalized by electrochemical active surface area also support the individual half‐cell electrode performance, such as 0.05 M (20.19 A g−1 and 0.69 s−1) and 0.025 M (−41.91 A g−1 and −1.53 s−1) at 550 and −150 mV for OER and HER, respectively. An H‐type cell constructed with an anion exchange membrane delivers robust stability even at a substantially higher current density of 200 mA cm−2 for over 56 hours with the highest Faradaic efficiency of 98.64 % at 1.6 V vs. reversible hydrogen electrode in 1 M KOH.
A Single‐Pot Co‐Precipitation Synthesis Route for Ni‐Rich Layered Oxide Materials with High Cycling Stability
Authors: Pollen Harald Norrud , Tolchard Julian Richard , Svensson Ann Mari , Wagner Nils Peter 
Published: September 2022

AbstractIn this work we report variations of LiNi0.88Mn0.06Co0.06O2 synthesised through a single‐pot oxalic acid co‐precipitation route, in which all cation precursors were added in the same step. The effects of Al‐doping, heat‐treatment temperature and Li precursor excess were investigated with physicochemical and electrochemical characterisation. Phase pure and well‐ordered polycrystalline materials were successfully synthesised for all Al‐doped and undoped compositions. Undoped LiNi0.88Mn0.06Co0.06O2 prepared at 750 °C with 4 at% excess Li precursor showed excellent cycling stability in NMC||LTO cells with an initial capacity of 201 mAh/g at 0.1 C at 20 °C, and a capacity retention of 81 % after 415 cycles. The Al‐doped variations LiNi0.88Mn0.04Co0.06Al0.02O2 and LiNi0.88Mn0.06Co0.04Al0.02O2 were synthesised, and they showed similar initial electrochemical performance to undoped LiNi0.88Mn0.06Co0.06O2, but Al‐doping via the oxalic acid co‐precipitation route resulted in shorter cycle life. The study outlines the importance of the processing parameters to achieve Ni‐rich layered oxides with a long cycle life without further surface modifications.
Magnetic Hyperthermia Enhancement in Iron‐based Materials Driven by Carbon Support Interactions
Authors: Vizcaíno‐Anaya Lucía , Herreros‐Lucas Carlos , Vila‐Fungueiriño José M. , del Carmen Giménez‐López María 
Published: September 2022

AbstractMagnetic hyperthermia (MH) shows great potential in clinical applications because of its very localized action and minimal side effects. Because of their high saturation magnetization values, reduced forms of iron are promising candidates for MH. However, they must be protected in order to overcome their toxicity and instability (i. e., oxidation) under biological conditions. In this work, a novel methodology for the protection of iron nanoparticles through confinement within graphitic carbon layers after thermal treatment of preformed nanoparticles supported on carbon is reported. We demonstrate that the size and composition of the nascent confined iron nanoparticles, as well as the thickness of their protective carbon layer can be controlled by selecting the nature of the carbon support. Our findings reveal that a higher nanoparticle–carbon interaction, mediated by the presence of oxygen‐containing groups, induces the formation of small and well‐protected α‐Fe‐based nanoparticles that exhibit promising results towards MH based on their enhanced specific absorption rate values.
Catalytic Enantioselective Synthesis of Helicenes
Authors: Liu Wei , Qin Tianren , Xie Wansen , Yang Xiaoyu 
Published: September 2022

AbstractHelicenes and helicene‐like molecules, usually containing multiple ortho‐fused aromatic rings, possess unique helical chirality. These compounds have found a wide range of important applications in many research fields, such as asymmetric catalysis, molecular recognition, sensors and responsive switches, circularly polarized luminescence materials and others. However, the catalytic enantioselective synthesis of helicenes was largely underexplored, when compared with the enantioselective synthesis of molecules bearing other stereogenic elements (e.g. central chirality and axial chirality). Since the pioneer work of asymmetric synthesis of helicenes via enantioselective [2+2+2] cycloaddition of triynes by Stará and Starý, last two decades have witnessed the tremendous development in the catalytic enantioselective synthesis of helicenes. In this review, we comprehensively summarized the advances in this field, which include methods enabled by both transition metal catalysis and organocatalysis, and provide our perspective on its future development.
Research on the mechanism of bed agglomeration and superheater fouling in CFB boiler fired pure petroleum coke
Authors: Liu Zhihong , Deng Boyu , Li Qingsong , Jin Yan , Liang Zuian , Yang Hairui , Zhang Man 
Published: September 2022

AbstractCirculating fluidized bed combustion is an effective method for the clean and efficient utilization of high‐sulphur petroleum coke. In the actual production and operation process, there are serious problems of bed agglomeration and superheater fouling. The chemical and mineral compositions of the deposition were analyzed by X‐ray diffraction (XRD) and X‐ray fluorescence spectroscopy (XRF), and the effects of CaO sulphation and V2O5 on bed agglomeration and superheater deposits were studied through targeted experiments. The research results show that the sulphation process of CaO is the cause of bed agglomeration, and the superheater fouling is the result of the combined action of K2SO4 condensation and CaO sulphation; V2O5 in petroleum coke ash catalyzes the oxidation reaction of SO2 to accelerate the sulphation of CaO, thereby accelerating the development of bed agglomeration and superheater fouling.
Ring‐Opening Polymerization of a Benzyl‐Protected Cyclic Ester towards Functional Aliphatic Polyester†
Authors: Yang Xing , Fan Hua‐Zhong , Cai Zhongzheng , Zhang Qi , Zhu Jian‐Bo 
Published: September 2022

Comprehensive SummaryMonomer design strategy has become a powerful tool to access polymers with desired and diverse functionalities. Here, we designed a novel monomer 2‐((benzyloxy)methyl)‐1,4‐oxathiepan‐7‐one (BTO) via installing a benzyl ether side chain to the structure of 1,4‐oxathiepan‐7‐one (OTO). The ring‐opening polymerization of BTO with Zn1 as the catalyst demonstrated the characteristics of living polymerization with turnover frequency (TOF) up to 2520 h−1. With a [BTO]0/[Zn1]0/[I]0 feed ratio of 2000/2/1, polymer with high number‐average molecular weight (Mn = 536 kDa) and narrow dispersity (Ð = 1.06) was obtained. The produced polymer with a glass transition temperature of ‐17°C behaved as an elastomer at room temperature. Consequently, the monomer BTO was copolymerized with L‐LA to modulate the mechanical properties of P(L‐LA). When the BTO content is 10%, the copolymer exhibits excellent strength (24 MPa) and elongation at break (270%), affording a crystalline, hard, and tough plastic material that combines the high ductility of P(BTO) and the high modulus of P(L‐LA). In addition, the oxidation of P(BTO) to P(BTO)‐SO2 led to an improvement of Tg from ‐17°C to 38°C. Debenzylation of P(BTO)‐SO2 afforded P(BTO)‐SO2‐OH containing free hydroxyl groups. Ultimately, P(BTO) could be hydrolyzed under a base condition to recover the corresponding hydroxyl acid intermediate, which could be used to prepare the monomer again and complete the closed‐loop from monomer to polymer to monomer.
3D hierarchical architectures of CoSe2 nanoparticles embedded in rice‐derived hard carbon for advanced sodium storage
Authors: Lin Congjian , Zhang Jintao , Lim Yew Von , Yan Dong , Li Ke , Leong Zhi Yi , Vafakhah Sareh , Li Yifan , Silva Arlindo , Yang Hui Ying 
Published: September 2022

AbstractA low‐cost and feasible method to fabricate three‐dimensional (3D) hierarchical composites composed of CoSe2 nanoparticles embedded in rice‐derived hard carbon (HC) interconnected with carbon nanotubes (CNTs) is devised in this study. The deployment of CoSe2 in the elecrode has provided a very high rate capacity, which is crucial for sodium‐ion commercialization. The deployment of HC with CNTs further provides a 3D hierarchical structure effective in shortening the diffusion paths of both electrons and Na+ ions, offering abundance of active sodium storage sites. Consequently, the CoSe2 acted as an active material with the carbonaceous template, a commonly utilized sodium‐ion battery anode material, which exhibited a superior reversible capacity of 550 mAh g−1 at 0.5 A g−1, outstanding rate performance (451 mAh g−1 at 20 A g−1) and excellent cycling performance (~100% capacity retention over 2500 cycles at 20 A g−1 after electrochemical stabilization).
Electrophilicity of Hoveyda‐Grubbs Olefin Metathesis Catalysts as the Driving Force that Controls Initiation Rates
Authors: Martínez Juan Pablo , Trzaskowski Bartosz 
Published: September 2022

AbstractThe dissociative mechanism of initiation for a series of Hoveyda‐Grubbs type metathesis catalysts modified at the para and meta positions in the isopropoxybenzylidene ligand is investigated by means of DFT calculations. The electron donating/withdrawing capacity of the ligand was screened through the incorporation of various substituents such as halogens, nitro, alkoxides, ketones, esters, amines, and amides. Variations in structural parameters, energy barriers for the Ru−O bond dissociation, and Ru−O bond strength were examined as a function of the Hammett constant. It was found that electronic properties of the catalysts such as chemical potential, hardness, and electrophilicity correlate linearly with the dissociative energy barriers. These findings enable a systematic rationalization and prediction of rate of precatalyst initiation through the calculation of only the HOMO‐LUMO gap of catalysts, as the faster the initiation, the more electrophilic the catalyst.
Selective Degradation and Quantification of Nucleoporins in the Nuclear Pore by Auxin‐Inducible Degrons and Single‐Molecule Microscopy
Authors: Tingey Mark , Li Yichen , Yang Weidong 
Published: September 2022

AbstractThere is a significant current question regarding the viable copy numbers of nucleoporins required for the function of the nuclear pore complex (NPC) in eukaryotic cells. The NPC consists of approximately 30 different nucleoporins in an eight‐fold symmetry, meaning that there are multiple duplicates of each nucleoporin present within the nuclear pore. We recently developed a method that combines auxin‐inducible degrons and single‐molecule super‐resolution microscopy to evaluate the copy number of nuclear basket nucleoporins required for the successful function of the NPC. Here, we describe the theory behind this auxin‐inducible degron and single‐molecule super‐resolution microscopy method, and we detail a step‐by‐step process to selectively degrade nucleoporins either completely or in a stepwise manner. © 2022 Wiley Periodicals LLC.Basic Protocol 1: Degradation of target nucleoporinsBasic Protocol 2: Quantification of nucleoporin copy number via narrow‐field fluorescence microscopy
Effect of preparation design on marginal adaptation and fracture strength of ceramic occlusal veneers: A systematic review
Authors: Sirous Samin , Navadeh Arghavan , Ebrahimgol Saeedeh , Atri Faezeh 
Published: September 2022

AbstractObjectivesThis systematic review aims to investigate the effect of different preparation designs on the marginal fit and fracture strength of ceramic occlusal veneers.Materials and MethodsBased on the PICO question and the search terms, an electronic search was performed in Google Scholar, PubMed (MEDLINE), Scopus, Cochrane Library, Web of Science, Science Direct, Wiley, Ovid, and SAGE for articles published up to July 2022. After including English in vitro studies that evaluated posterior ceramic occlusal overlays at the posterior with ceramic restorations by following the PRISMA statement, the extracted data was tabulated. The methodological quality of the included studies was evaluated. Risk of bias assessment was done independently by two authors using the modified MINORS scale.ResultsAbout 3138 search results were screened, of which 22 were selected due to their titles. Twenty‐one full‐text articles were assessed for eligibility. Seventeen in‐vitro studies were finalized for the extraction of quantitative data. All 17 articles had a low risk of bias and were retained. The influencing items for evaluating the research were different in most studies; therefore, qualitative synthesis of the results was feasible. They generally included preparation design, material thickness, depth of preparation in the tooth, internal divergence angle, and finish line. Meta‐analysis was not done due to heterogeneity of preparation types and evaluation methods. Results revealed that fracture resistance of occlusal veneers is higher than normal mastication force, and it is sufficient to prepare the occlusal surface, use a self‐etching primer for bonding, and an acceptable minimum ceramic thickness. The marginal discrepancy of occlusal veneers is clinically acceptable. However, this systematic review faces some limitations due to the lack of in vivo studies, different preparation designs in included studies, different follow‐ups, and lack of comprehensive explanations in articles.ConclusionsThe preparation design of occlusal veneers influences both marginal adaptation and fracture resistance. Various preparation designs are proven to have clinically acceptable fracture strength and marginal adaptation.
Sustainability restatements, firm risk and controversial industries: Analysing the signals based on revision type
Authors: Martínez‐Ferrero Jennifer , Guidi Michele , García‐Meca Emma 
Published: September 2022

AbstractThis study analyses the relationship between sustainability reporting and firm risk by investigating the correlation between sustainability restatements and stock return volatility. Regression models, employed on a sample of 1580 sustainability reports by 353 European companies, evidence the risk relevance of restatement issuance. Investors interpret different signals, reacting with diverse feedbacks, based on the type of revision and whether the firm belongs to controversial industries or not. In general, restatements decrease firm risk when their purpose is to update reporting methodologies, while the opposite effect occurs when they amend errors and omissions. For companies operating in controversial industries, both types of sustainability restatement increase firm risk, with a stronger correlation when revisions redress errors or omissions. Given that sustainability reporting is still characterised by frequent standard and methodology updates, that often lead to the issuance of restatements, this study presents insights for companies and investors.
Wireless power transfer system with dual‐frequency operation in transmitter side for motor control application
Authors: Büyük Mehmet 
Published: September 2022

AbstractIn this paper, a transmitter‐side control method is proposed in inductive wireless power transfer (I‐WPT) model for the speed and power control of a single‐phase induction motor (SPIM). Resonant tanks with an electronic driving mechanism are used in the proposed configuration. The receiver side employs two resonant circuits with two full wave rectifiers, comparator, and two gate drivers for the management of the motor speed and power. The resonant circuits and electronic motor drive are presented through detailing the mathematical model and system design. In addition, a comparative section of the proposed model with the previous art is introduced to address the contributions of the paper. Moreover, a prototype model of the proposed topology has been created in simulation environment and tested in a variety of scenarios. The proposed I‐WPT model has a power rating of 140 W, whereas the SPIM has a power rating of 120 W. At full power operation, a 130 W power is supplied from the source during 118 W power consumption of SPIM, indicating that the system's efficiency is over 90%. The motor speed control has been tested by lowering the operation frequency of the motor terminal voltage from 60 to 40 Hz and from 40 to 20 Hz. The dynamic motor power has been also analyzed by reducing the load power from 100% to 70%. The findings reveal that the proposed transmitter‐side controlled I‐WPT system operates in a wide range of circumstances.