bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cushing’s disease: adrenal steroidogenesis inhibitors
Authors: Pivonello Rosario , Simeoli Chiara , Di Paola Nicola , Colao Annamaria 
Published: August 2022

AbstractCushing’s disease (CD), caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumor, is the most common form of Cushing’s syndrome (CS), accounting for approximately 70% of cases. CD requires a prompt diagnosis, an adequate treatment selection, and long-term management to limit hypercortisolism duration and long-term complications and improve patient outcomes. Pituitary surgery is the first-line option, which is non-curative in one third of patients, therefore requiring additional treatments. Medical therapy has recently acquired an emerging role, with the availability of several drugs with different therapeutic targets, efficacy and safety profiles. The current review focuses on efficacy and safety of steroidogenesis inhibitors, and particularly the historical drugs, ketoconazole and metyrapone, and the novel drugs levoketoconazole and osilodrostat, which seem to offer a rapid, sustained, and effective disease control. Ketoconazole should be preferred in females and in patients without severe liver disease; levoketoconazole may offer an alternative to classical ketoconazole, appearing characterized by a higher potency and potential lower hepatotoxicity compared to ketoconazole. Metyrapone should be preferred in males and in patients without severe or uncontrolled hypokalemia. Both ketoconazole and metyrapone may be preferred for short-term more than for long-term treatment. Osilodrostat may represent the best choice for long-term treatment, in patients with poor compliance to the multiple daily administration schedule, and in patients without severe or uncontrolled hypokalemia. Steroidogenesis inhibitors may be used alone or in combination, and associated with pituitary directed drugs, to improve the efficacy of the single drugs, allowing a potential use of lower doses for each drug, and hypothetically reducing the rate of adverse events associated with the single drugs. Clinicians may tailor medical therapy on the specific clinical scenario, considering disease history together with patients’ characteristics and hypercortisolism’s degree, addressing the needs of each patient in order to improve the therapeutic outcome and to reduce the burden of illness, particularly in patients with persistent or recurrent CD.
Correlation of UAV and satellite-derived vegetation indices with cotton physiological parameters and their use as a tool for scheduling variable rate irrigation in cotton
Authors: Lacerda L. N. , Snider J. , Cohen Y. , Liakos V. , Levi M. R. , Vellidis G. 
Published: August 2022

AbstractCurrent irrigation management zones (IMZs) for variable rate irrigation (VRI) systems are static. They are delineated in the beginning of the season and used thereafter. However, recent research has shown that IMZ boundaries are transient and change with time during the growing season. The primary goal of this study was to explore the potential of using vegetation indices (VIs) developed from unmanned aerial vehicle (UAV) and satellite images to predict cotton physiological parameters that can be used to delineate in-season boundaries of IMZs. A 2 year study was conducted in a 38 ha commercial cotton field in southwestern Georgia, USA. Throughout the two growing seasons, VIs were calculated from UAV, PlanetScope, and Sentinel-2 images. Predawn leaf water potential (LWPPD) and plant height were measured at 37 locations in the field on the same day as the flights and correlated with UAV and satellite based-VIs. GNDVI (Green normalized difference vegetation index) was the best predictor of plant height with correlation values of 0.72 (p < .0001) and 0.84 (p < .0001) for 2019 and 2020, respectively. A secondary goal was to compare the performance of dynamic VRI (DVRI) to conventional irrigation. The field was divided into alternating parallel conventional, and DVRI strips to compare the two scheduling methods. The conventional strips were irrigated using the farmer’s standard method and individual IMZs within the DVRI strips were irrigated based on soil water tension (SWT) measured with a wireless soil moisture sensor network. LWP and SWT measurements correlated well. IMZs were initially delineated using soil texture, apparent soil electrical conductivity (ECa), and yield maps and satellite images from previous years and were modified in-season to reflect patterns observed in the plant height maps. In 2020, the DVRI system prescribed an average irrigation amount of 50.8 mm while conventional irrigation applied an average of 58.4 mm. Average yields for DVRI and conventional were 1248 and 1191 kg ha−1, respectively. The DVRI system resulted in average yield 4.6% higher than conventional irrigation, while applying 14.0% less water. Despite the lower water application by the DRVI system, the performance comparison between the DRVI and the conventional irrigation was not conclusive.
Psychometric properties of kidney disease quality of life-36 (KDQOL-36) in dialysis patients in Indonesia
Authors: Rokhman M. Rifqi , Wardhani Yulia , Partiningrum Dwi Lestari , Purwanto Barkah Djaka , Hidayati Ika Ratna , Idha Arofa , Thobari Jarir At , Postma Maarten J. , Boersma Cornelis , van der Schans Jurjen 
Published: August 2022

Abstract
Objective
The study aimed to evaluate the psychometric properties of KDQOL-36 Bahasa Indonesia in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients in Indonesia.

Methods
The psychometric analysis was conducted in three hospitals offering both HD and CAPD. The validity was assessed through structural, convergent, and known-group validity, while reliability was evaluated using internal consistency and test–retest reliability.

Results
The study involved 370 participants of which 71% received HD treatment. No floor and ceiling effects (< 10%) were identified. Confirmatory factor analysis supported a good model fit for both generic and kidney-specific domains, while exploratory factor analysis revealed three factors for kidney-specific domains and only three items with a loading factor below 0.4. Convergent validity showed positive correlations between kidney-specific domains, generic domains, and EQ-5D. The comparison of quality of life among subgroups based on dialysis type and whether or not patients had diabetes supported the hypotheses of known-group validity. Cronbach’s alpha and omega values had demonstrated good internal consistency. Test–retest reliability indicated burden of kidney disease had good reliability, while other domains had moderate reliability.

Conclusion
The study supports the validity and reliability of both generic and kidney-specific domains of KDQOL-36 Bahasa Indonesia to evaluate quality of life in patients with HD and CAPD in Indonesia. As health-related quality of life is a crucial predictor of patient outcomes, this report contributes new evidence about validity and reliability to recommend the use of KDQOL-36 Bahasa Indonesia in dialysis centers.
Privacy-preserving edge computing offloading scheme based on whale optimization algorithm
Authors: Liu Zhenpeng , Wang Jingyi , Gao Zilin , Wei Jianhang 
Published: August 2022

AbstractAiming at the problem of user’s task offloading in mobile edge computing and the potential leakage of location privacy during the offloading process, a privacy-preserving computing offloading scheme based on whale optimization algorithm is proposed. Using differential privacy technology to obfuscate the user's location information, the user can make task offloading decisions according to the obfuscated distance. Considering the delay, energy consumption, and their weighted sum, the offloading problem is modeled as a convex optimization problem. Then, the whale optimization algorithm is adopted to solve this optimization problem to achieve a balance between privacy protection and resource consumption. Experiments are conducted to verify the relationship between the degree of privacy leakage, the computation-offloading cost and real distance, privacy-preserving impact factor, the respective weights of time delay and energy consumption The experimental results show that the offloading scheme proposed in this paper has good performance in terms of cost and privacy protection.
Pharmacokinetic and pharmacodynamic profiles of a novel phospholipid-aspirin complex liquid formulation and low dose enteric-coated aspirin: results from a prospective, randomized, crossover study
Authors: Franchi Francesco , Schneider David J. , Prats Jayne , Fan Weihong , Rollini Fabiana , Been Latonya , Taatjes-Sommer Heidi S. , Bhatt Deepak L. , Deliargyris Efthymios N. , Angiolillo Dominick J. 
Published: August 2022

AbstractLow dose enteric-coated aspirin (EC-ASA) is routinely used for secondary cardiovascular event prevention. However, absorption of EC tablets is poor, which can result in subtherapeutic antiplatelet effects. Phospholipid-aspirin liquid filled capsules (PL-ASA) are a novel FDA-approved immediate-release formulation designed to reduce gastrointestinal (GI) injury by limiting direct contact with the stomach lining. We compared the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of PL-ASA versus EC-ASA at a low dose. This randomized, open-label, crossover study assessed PK and PD following a single 81-mg dose of PL-ASA versus EC-ASA under fasting conditions in 36 volunteers without cardiovascular disease between 18 and 75 years of age. Volunteers were randomly assigned 1:1 to either PL-ASA then EC-ASA or vice versa with a minimum 14-day washout. Assessments included PK parameters for acetylsalicylic acid and salicylic acid, platelet aggregation in response to arachidonic acid (AA), and serum thromboxane B2 (TxB2) assessments over 24 h. PL-ASA was rapidly absorbed. PL-ASA reached Tmax 3 h earlier (1.01 vs. 4.00 h, p < 0.0001), with almost double the Cmax (720 vs. 368 ng/mL, p < 0.0001) and overall 44% higher exposure of acetylsalicylic acid (AUC0-t: 601 vs. 416 h*ng/mL, p = 0.0013) compared with EC-ASA. Within 1 h of dosing, PL-ASA achieved significantly lower residual platelet aggregation, which persisted for the full 24 h (median AA-LTA was 47% with PL-ASA vs. 80.5% with EC-ASA; p = 0.0022 at hour-24). Treatment with PL-ASA also resulted in significantly lower serum TxB2 concentrations at each time point compared with EC-ASA (all p-values < 0.05). PL-ASA resulted in faster and more complete aspirin absorption paralleled by more prompt and potent platelet inhibition compared with EC-ASA after a single 81 mg dose. PL-ASA represents an attractive novel aspirin formulation for the secondary prevention of cardiovascular events.Clinical Trial Registration ClinicalTrials.gov identifier: NCT04811625.
Effects of air pollution on myopia: an update on clinical evidence and biological mechanisms
Authors: Yuan Tianyi , Zou Haidong 
Published: August 2022

AbstractMyopia is one of the most common forms of refractive eye disease and considered as a worldwide pandemic experienced by half of the global population by 2050. During the past several decades, myopia has become a leading cause of visual impairment, whereas several factors are believed to be associated with its occurrence and development. In terms of environmental factors, air pollution has gained more attention in recent years, as exposure to ambient air pollution seems to increase peripheral hyperopia defocus, affect the dopamine pathways, and cause retinal ischemia. In this review, we highlight epidemiological evidence and potential biological mechanisms that may link exposure to air pollutants to myopia. A thorough understanding of these mechanisms is a key for establishing and implementing targeting strategies. Regulatory efforts to control air pollution through effective policies and limit individual exposure to preventable risks are required in reducing this global public health burden.
On the automatic parameter calibration of a hypoplastic soil model
Authors: Machaček Jan , Staubach Patrick , Tavera Carlos Eduardo Grandas , Wichtmann Torsten , Zachert Hauke 
Published: August 2022

AbstractThis paper presents an approach for the automatic parameter calibration (AC) of a hypoplastic constitutive soil model. The calibration software developed in this work simplifies the parameter calibration, reduces the subjective “human” factor on the calibration result and lowers the entry hurdle for the use of the hypoplastic constitutive model. The performance of the software was demonstrated by comparing automatically calibrated parameter sets for two sands and their related simulations of the underlying experimental data with simulations using two reference parameter sets. The first reference parameter set was calibrated the classical way, "by hand", and the second was calibrated using the AC tool ExCalibre. Two different optimization methods were used, namely the Differential Evolution (DE) and the Particle Swarm Optimization (PSO). The simulations performed with the parameters obtained from the AC agree well with the experimental data and show improvements over the reference parameter sets. With respect to the optimization method, the performance of the DE proved superior to that of the PSO. Various measures of comparison were examined to quantify the discrepancy between experiment and simulation. By repeating 500 calibration runs, the dispersion of parameters was determined and correlations between different parameters of the hypoplastic model were found.
Lean Implementation for Graduating Optimally Controlled Stable Type 2 Diabetics from Endocrine Specialty Clinic Back to Primary Care
Authors: Burmeister Lynn A. , Harper Peter G. , Brueggemann Alvina , Adam Patricia , Logeais Mary , Schechter Kelly , Duncan Katie , Boyer Holly 
Published: August 2022

Abstract
Introduction
Endocrine specialty clinics (SCs) are occupied by a high percentage of stable follow-up patients, limiting access to new patients with greater needs.

Aim
Feasibility project to improve access to diabetes SC by reducing the number of stable optimally controlled follow-up type 2 diabetic patients.

Setting
M Health Fairview (MHFV), a hybrid network of University of Minnesota academic and Fairview Health community hospitals and clinics with affiliated providers.

Program Description
A team-based lean methodology quality improvement graduation program including medical assistants, nurses, physicians, and a compact with primary care (PC) was used to identify within the Endocrine clinic population the graduation-eligible optimally controlled stable type 2 diabetic patients, acclimate them to the graduation concept, engage in shared decision-making, and transition them back to PC with a warm hand-off and graduation certificate.

Program Evaluation
Seventeen percent (58/341) of eligible patients with optimally controlled diabetes graduated by 6 months, ranging between 0 and 83% per week.

Discussion
The innovation and feasibility of opening SC access through the use of a team-based graduation program to transfer stable diabetes patients back to their home clinic was demonstrated. This innovation has the potential to support health system triage of new patients to limited access specialty care.
Datenjournalismus in Deutschland revisited
Authors: Weinacht Stefan , Spiller Ralf 
Published: August 2022

ZusammenfassungDer Datenjournalismus wird gleichermaßen stark in der Nachrichtenbranche beobachtet und in der Journalismusforschung reflektiert. Dieser Beitrag beschreibt das Phänomen zunächst im Kontext des Megatrends der Automatisierung des Journalismus. Anschließend wird die erste Trendstudie zum Datenjournalismus in Deutschland vorgestellt: Die Berufsfeldstudie war 2012 und 2019 im Feld. Die gewählten Items ermöglichen einen Längsschnitt-Vergleich der Entwicklung des Datenjournalismus. Bei einem Vergleich mit den nationalen Daten der „Worlds of Journalism Study“ werden weitere Gemeinsamkeiten und Unterschiede deutlich. Die Ergebnisse zeigen, dass sich der Datenjournalismus in Deutschland zunehmend institutionalisiert hat und Datenjournalist:innen sich stark einem investigativen politischen Journalismus verpflichtet fühlen.
Influence of Metal Flank Hardness of Machined and Cold Forged Gears on Wear within a Metal-Polyamide Gear Pair and Targeted Process Adaptation
Authors: Rohrmoser Andreas , Merklein Marion 
Published: August 2022

AbstractMetal-polyamide gear pairs provide advantages but their application is limited due to wear. The properties of the metallic gearing significantly affect the wear behavior. However, the influence of varying metallic materials as well as flank hardness is not known. Within this contribution, the occurring wear mechanisms when applying steel, brass and aluminum with varying hardness resulting from manufacturing by machining and cold forging were identified. Depending on the hardness of the metallic tooth flank, the release of metallic particles (3-body abrasion) or surface roughening (2-body abrasion) results. The formation of a wear-reducing transfer film is only possible with sufficient strength of the metallic tooth flank and tribological compatibility. Maximum wear occurs at a metal hardness of about 120 HV due to 3-body abrasion with high abrasive effect of the metallic particles. The adaptation of the cold forging process enables a local increase in the plastic strain of the tooth flank by 84% resulting in an elevated tooth flank hardness (+ 53%) for aluminum and significantly reduced wear. Furthermore, the formation of a wear-reducing transfer film results. Aluminum pinions produced in the adapted cold forging process achieve performance level of steel within the investigated load case.
Detoxification enzyme activity, reproductive and developmental fitness of abamectin-resistant Bryobia praetiosa (Acari:Tetranychidae)
Authors: Ou Chun , Jiang Nan , Cheng Wenhui , Lei Tiantian , Jiang Shuanglin , Yao Xiamei 
Published: August 2022

AbstractAbamectin is an important and environmentally friendly antibiotic pesticide, and its resistance has become an area of intense research. In this study, we employed laboratory bioassays, biochemical analyses, and life history analyses to systematically evaluate abamectin resistance, the underlying biochemical mechanisms of resistance, and the reproductive and developmental characteristics of the arthropod pest Bryobia praetiosa. An abamectin-resistant B. praetiosa strain (RR) was obtained by intensive selection of an abamectin-susceptible strain (SS) using abamectin exposure in the laboratory for 24 generations, yielding a resistance index (RI) of 30.11. Comparison of detoxification enzymes suggested that the specific activities of carboxylesterases (CarEs), glutathione S-transferases (GSTs), and mixed-function oxidases (MFOs) in the RR strain were higher than those of the SS strain by 1.13-, 1.75-, and 4.02-fold, respectively. GST and MFOS protein concentrations were also significantly different between RR and SS strains. Further analysis of life history parameters demonstrated that the developmental duration and lifespan of RR strain in addition to egg numbers were markedly decreased relative to SS strain. The net reproductive rate (R0), finite rate of increase (λ), and population doubling time (Dt) of RR strain were significantly lower than those of SS strain. The results indicated that the RR strain was more disadvantageous in developmental and reproductive characteristics than the SS strain. In addition, the relative fitness value of the resistant strain is about half (Rf = 0.49) that of the susceptible strain. In conclusion, increased abamectin resistance in B. praetiosa was associated with a rapid increase in MFOs activity, while GSTs also played a role in abamectin resistance development and RR strain exhibited reproductive disadvantages.
Cytoreductive Surgery and HIPEC for Regionally Advanced Gallbladder Cancer: a Case Report
Authors: Huang Fay , Shamavonian Raphael , Morris David L. 
Published: August 2022

AbstractGallbladder cancer is a rare cancer, associated with an extremely poor prognosis. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is not commonly performed in gallbladder cancer; however, case series have shown prolonged survival time with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in gallbladder cancer and no increase in morbidity compared to cytoreductive surgery without hyperthermic intraperitoneal chemotherapy. We present a case of gallbladder cancer with peritoneal metastases in a 60-year-old male who was successfully treated with complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy and survived for 4 years following diagnosis.
Electron beam welding of 2205 duplex stainless steel with nickel-based filler wire using multi-beam technique
Authors: Tóth Tamás , Hensel Jonas , Hesse Ann-Christin , Dilger Klaus 
Published: August 2022

AbstractThe duplex stainless steels have many favorable properties attributed to their two-phase microstructure consisting of almost equal fractions of ferrite and austenite. Therefore, they are widely used in the offshore, petroleum, and chemical industries as a base material for pressure vessels and pipelines. Such components often possess large thicknesses, which can be effectively welded with electron beam. This process is characterized by rapid cooling combined with a relatively great loss of nitrogen, resulting in insufficient austenite formation. To compensate this phenomenon, the addition of nickel, in the form of wire, was performed in this study. This promoted the formation of austenite at the same cooling rate, so that approximately an equal amount of ferrite and austenite was achieved. Beam oscillation was applied to maintain good dilution even at large depth/width ratios. Furthermore, the multi-beam technique was implemented to reduce the spatter formation and provide a higher process stability. This allows the spatial, but not temporal, separation of the melting-off of the wire and the main welding process. The joints produced in this way exhibit a good weld dilution and consequently an austenite distribution with a low inhomogeneity. Additionally, a narrow heat-affected zone was produced.
Indigenous Inclusion and Indigenising the University
Authors: Hoskins Te Kawehau , Jones Alison 
Published: August 2022

Abstract‘Indigenous inclusion’ has been the most common approach to Māori engagement in university education in Aotearoa-New Zealand. Increasingly, another orientation, based on different premises, which might be called ‘indigenisation’, is becoming evident. We argue that indigenisation offers more hopeful possibilities for New Zealand universities as they/we continue to think about their/our obligations under Te Tiriti o Waitangi.
Analysis of ownership network of European companies using gravity models
Authors: Kosztyán Zsolt Tibor , Király Ferenc , Kurbucz Marcell T. 
Published: August 2022

AbstractSocial network analysis is increasingly applied to modeling regional relationships. However, in this scenario, we cannot ignore the geographical economic and technological nature of the relationships. In this study, the tools of social network analysis and the gravity model are combined. Our study is based on the Amadeus database of European organizations, which includes 24 million companies. The ownership of parent subsidiaries was modeled using economic, technological, and geographic factors. Ownership was aggregated to the NUTS 3 regional level, to which average corporate profitability indicators, the GDP per capita characterizing the economic environment, and the number of patents, which is a proxy of the technological environment, were assigned to NUTS 3 regions. The formation of the ownership network between 2010 and 2018 was characterized using this dataset. As the proposed model accurately describes the formation of ownership relationships marked with edges, it is possible to estimate network properties, such as modularity and centrality.