bluuebunny/crossref_metadata_2025_split huggingface dataset:
At the Crux of Joint Crosstalk: TGFβ Signaling in the Synovial Joint
Authors: Bailey Karsyn N. , Alliston Tamara 
Published: May 2022

AbstractPurpose of ReviewThe effect of the transforming growth factor beta (TGFβ) signaling pathway on joint homeostasis is tissue-specific, non-linear, and context-dependent, representing a unique complexity in targeting TGFβ signaling in joint disease. Here we discuss the variety of mechanisms that TGFβ signaling employs in the synovial joint to maintain healthy joint crosstalk and the ways in which aberrant TGFβ signaling can result in joint degeneration.Recent FindingsOsteoarthritis (OA) epitomizes a condition of disordered joint crosstalk in which multiple joint tissues degenerate leading to overall joint deterioration. Synovial joint tissues, such as subchondral bone, articular cartilage, and synovium, as well as mesenchymal stem cells, each demonstrate aberrant TGFβ signaling during joint disease, whether by excessive or suppressed signaling, imbalance of canonical and non-canonical signaling, a perturbed mechanical microenvironment, or a distorted response to TGFβ signaling during aging.SummaryThe synovial joint relies upon a sophisticated alliance among each joint tissue to maintain joint homeostasis. The TGFβ signaling pathway is a key regulator of the health of individual joint tissues, and the subsequent interaction among these different joint tissues, also known as joint crosstalk. Dissecting the sophisticated function of TGFβ signaling in the synovial joint is key to therapeutically interrogating the pathway to optimize overall joint health.
Treatment with IFB-088 Improves Neuropathy in CMT1A and CMT1B Mice
Authors: Bai Yunhong , Treins Caroline , Volpi Vera G. , Scapin Cristina , Ferri Cinzia , Mastrangelo Rosa , Touvier Thierry , Florio Francesca , Bianchi Francesca , Del Carro Ubaldo , Baas Frank F. , Wang David , Miniou Pierre , Guedat Philippe , Shy Michael E. , D’Antonio Maurizio 
Published: May 2022

AbstractCharcot-Marie-Tooth disease type 1A (CMT1A), caused by duplication of the peripheral myelin protein 22 (PMP22) gene, and CMT1B, caused by mutations in myelin protein zero (MPZ) gene, are the two most common forms of demyelinating CMT (CMT1), and no treatments are available for either. Prior studies of the MpzSer63del mouse model of CMT1B have demonstrated that protein misfolding, endoplasmic reticulum (ER) retention and activation of the unfolded protein response (UPR) contributed to the neuropathy. Heterozygous patients with an arginine to cysteine mutation in MPZ (MPZR98C) develop a severe infantile form of CMT1B which is modelled by MpzR98C/ + mice that also show ER stress and an activated UPR. C3-PMP22 mice are considered to effectively model CMT1A. Altered proteostasis, ER stress and activation of the UPR have been demonstrated in mice carrying Pmp22 mutations. To determine whether enabling the ER stress/UPR and readjusting protein homeostasis would effectively treat these models of CMT1B and CMT1A, we administered Sephin1/IFB-088/icerguestat, a UPR modulator which showed efficacy in the MpzS63del model of CMT1B, to heterozygous MpzR98C and C3-PMP22 mice. Mice were analysed by behavioural, neurophysiological, morphological and biochemical measures. Both MpzR98C/ + and C3-PMP22 mice improved in motor function and neurophysiology. Myelination, as demonstrated by g-ratios and myelin thickness, improved in CMT1B and CMT1A mice and markers of UPR activation returned towards wild-type values. Taken together, our results demonstrate the capability of IFB-088 to treat a second mouse model of CMT1B and a mouse model of CMT1A, the most common form of CMT. Given the recent benefits of IFB-088 treatment in amyotrophic lateral sclerosis and multiple sclerosis animal models, these data demonstrate its potential in managing UPR and ER stress for multiple mutations in CMT1 as well as in other neurodegenerative diseases.
Graphical Abstract
(Left panel) the accumulation of overexpressed PMP22 or misfolded mutant P0 in the Schwann cell endoplasmic reticulum (ER) leads to overwhelming of the degradative capacity, activation of ER-stress mechanisms, and myelination impairment. (Right panel) by prolonging eIF2α phosphorylation, IFB-088 reduces the amount of newly synthesized proteins entering the ER, allowing the protein quality control systems to better cope with the unfolded/misfolded protein and allowing myelination to progress.
Safety aid elimination as a brief, preventative intervention for social anxiety: A randomized controlled trial in university students
Authors: Arai Honami , Ishikawa Shin-ichi , Okawa Sho , Kishida Kohei , Korte Kristina J. , Schmidt Norman B. 
Published: May 2022

AbstractAlthough there are a variety of treatment options for social anxiety, effective prevention strategies for those with subclinical social anxiety are limited. This study evaluated a single session group formatted prevention program focused on the reduction of safety behaviors in both a proof-of-concept study and a randomized controlled trial (RCT). Participants (N = 59) were nontreatment seeking Japanese university students with high levels of social anxiety. Participants were randomized to either an active treatment focused on identification and elimination of safety behavior or a control group involving the discussion of healthy coping strategies. Both conditions met for 120 min in small groups (4 to 6 participants per group). The preliminary proof-of-concept study as well as the RCT demonstrated high levels of acceptability. Findings from the RCT indicated significant improvement in social anxiety symptoms among those in the active treatment condition at post-treatment, which was maintained at follow-up. In addition, participants in the treatment condition showed significant improvement in levels of depression. The effect size difference in symptoms between conditions was in the large range. The present study provides preliminary support for the efficacy of a newly developed treatment program targeting safety behaviors in students with subclinical social anxiety. The current results also illustrate the promise of a brief, indicated prevention strategy focused on safety behavior among those with subclinical social anxiety.
Thyroid function after diagnostic 123I-metaiodobenzylguanidine in children with neuroblastic tumors
Authors: Clement Sarah C. , Tytgat Godelieve A. M. , van Trotsenburg A. S. Paul , Kremer Leontien C. M. , van Santen Hanneke M. 
Published: May 2022

Abstract
Background
Metaiodobenzylguanidine (MIBG) labeled with radioisotopes can be used for diagnostics 123I−) and treatment (131I−) in patients with neuroblastic tumors. Thyroid dysfunction has been reported in 52% of neuroblastoma (NBL) survivors after 131I-MIBG, despite thyroid protection. Diagnostic 123I-MIBG is not considered to be hazardous for thyroid function; however, this has never been investigated. Therefore, the aim of this study was to evaluate the prevalence of thyroid dysfunction in survivors of a neuroblastic tumor who received diagnostic 123I-MIBG only.

Methods
Thyroid function and uptake of 123I− in the thyroid gland after 123I-MIBG administrations were evaluated in 48 neuroblastic tumor survivors who had not been treated with 131I-MIBG. All patients had received thyroid prophylaxis consisting of potassium iodide or a combination of potassium iodide, thiamazole and thyroxine during exposure to 123I-MIBG.

Results
After a median follow-up of 6.6 years, thyroid function was normal in 46 of 48 survivors (95.8%). Two survivors [prevalence 4.2% (95% CI 1.2–14.0)] had mild thyroid dysfunction. In 29.2% of the patients and 11.1% of images 123I− uptake was visible in the thyroid. In 1 patient with thyroid dysfunction, weak uptake of 123I− was seen on 1 of 10 images.

Conclusions
The prevalence of thyroid dysfunction does not seem to be increased in patients with neuroblastic tumors who received 123I-MIBG combined with thyroid protection. Randomized controlled trials are required to investigate whether administration of 123I-MIBG without thyroid protection is harmful to the thyroid gland.
miR-16-5p Is a Novel Mediator of Venous Smooth Muscle Phenotypic Switching
Authors: Zhang Dengshen , Shi Jun , Liang Guiyou , Liu Daxing , Zhang Jian , Pan Sisi , Lu Yuanfu , Wu Qin , Gong Changyang , Guo Yingqiang 
Published: May 2022

AbstractVein graft failure after coronary artery bypass grafting (CABG) is primarily caused by intimal hyperplasia, which results from the phenotypic switching of venous smooth muscle cells (SMCs). This study investigates the role and underlying mechanism of miR-16-5p in the phenotypic switching of venous SMCs. In rats, neointimal thickness and area increased over time within 28 days after CABG, as did the time-dependent miR-16-5p downregulation and SMC phenotypic switching. Platelet-derived growth factor-BB-induced miR-16-5p downregulation in HSVSMCs was accompanied by and substantially linked with alterations in phenotypic switching indicators. Furthermore, miR-16-5p overexpression increased SMCs differentiation marker expression while suppressing HSVSMCs proliferation and migration and drastically inhibiting neointimal development in vein grafts. The miR-16-5p inhibited zyxin expression, which was necessary for HSVSMCs phenotypic switching. The miR-16-5p/zyxin axis is a novel, potentially therapeutic target for preventing and treating venous graft intimal hyperplasia.
Graphical abstract
Assessing laser ablation multi-collector inductively coupled plasma mass spectrometry as a tool to study archaeological and modern human mobility through strontium isotope analyses of tooth enamel
Authors: Boethius Adam , Ahlström Torbjörn , Kielman-Schmitt Melanie , Kjällquist Mathilda , Larsson Lars 
Published: May 2022

AbstractTo evaluate the possibility of obtaining detailed individual mobility data from archaeological teeth, the strontium isotope ratios on 28 human teeth from three separate Early-Mid Holocene, Swedish, foraging contexts (Norje Sunnansund, Skateholm and Västerbjers) were analysed through laser ablation. The teeth/individuals have previously been analysed using traditional bulk sampled thermal ionisation mass spectrometry. To validate the conclusions regarding the archaeological teeth, a tooth from a modern man with a known background was also analysed. The result shows that all of the teeth display less than 0.4% discrepancy between the mean values of the laser ablation profiles and the previously published bulk data and 25 (89%) of the teeth display less than a 0.2% discrepancy. By calculating linear and polynomial trendlines for each ablated tooth, it was possible to illustrate a strong correlation for the transition pattern between the measurements when following a chronological sequence from the tip to the cervix. Such correlations were not reproduced when the data sequence was randomized. The analyses show that the chronologically sequenced ablation data fit with a transition between local bioavailable strontium regions, that the measurements do not fluctuate between extremes and that their values are not caused by end-member mixing. This indicates an increasing data resolution when reducing strontium isotope ratio averaging time by minimizing the sampling area. The results suggest strontium incorporation in human teeth can be measured on an ordinal scale, with a traceable chronological order to enamel mineralization when sampled from tip to cervix at an equal distance from the surface. Micro-sampling enamel is considered a valid method to assess prehistoric, but not modern, human mobility; laser ablation technology increases the amount of information obtained from a single tooth while rendering minimal damage to the studied specimen.
Tribological properties of hierarchical micro-dimples produced on a cylindrical surface by dual-frequency texturing
Authors: Ali Saood , Kurniawan Rendi , Chul Park Gun , Ko Tae Jo 
Published: May 2022

AbstractAn experimental investigation was performed for investigating the tribological performance of micro-dimple surface texture patterns on a cylindrical surface in a realistic operating environment of starved lubrication. Micro-dimples were generated by a dual-frequency surface texturing method, in which a high-frequency (16.3 kHz) three-dimensional (3D) vibration and a low-frequency (230 Hz) one-dimensional (1D) vibration were applied at the tool tip simultaneously, resulting in the generation of the hierarchical micro-dimples in a single step. Rotating cylinder-on-pin tribological tests were conducted to compare the tribological performance of the non-textured reference specimen and micro-dimple samples. The effect of surface textures generated with various shape parameters (long drop and short drop), dimension parameters (length and surface texture density), and operation parameters (load and sliding velocity) on the tribological performance was evaluated. Stribeck curves indicate that the hierarchical micro-dimples exhibit a lower coefficient of friction than the reference specimen in the high contact-pressure regions. It is also observed that variation in the length of a micro-dimple, the shape effect, is the major factor affecting the friction response of the textured surfaces. The generation of additional hydrodynamic pressure and lift effect by hierarchical structures is the main reason for the improved performance of hierarchical micro-dimple surfaces.
Utilizing a Pretrained Language Model (BERT) to Classify Preservice Physics Teachers’ Written Reflections
Authors: Wulff Peter , Mientus Lukas , Nowak Anna , Borowski Andreas 
Published: May 2022

AbstractComputer-based analysis of preservice teachers’ written reflections could enable educational scholars to design personalized and scalable intervention measures to support reflective writing. Algorithms and technologies in the domain of research related to artificial intelligence have been found to be useful in many tasks related to reflective writing analytics such as classification of text segments. However, mostly shallow learning algorithms have been employed so far. This study explores to what extent deep learning approaches can improve classification performance for segments of written reflections. To do so, a pretrained language model (BERT) was utilized to classify segments of preservice physics teachers’ written reflections according to elements in a reflection-supporting model. Since BERT has been found to advance performance in many tasks, it was hypothesized to enhance classification performance for written reflections as well. We also compared the performance of BERT with other deep learning architectures and examined conditions for best performance. We found that BERT outperformed the other deep learning architectures and previously reported performances with shallow learning algorithms for classification of segments of reflective writing. BERT starts to outperform the other models when trained on about 20 to 30% of the training data. Furthermore, attribution analyses for inputs yielded insights into important features for BERT’s classification decisions. Our study indicates that pretrained language models such as BERT can boost performance for language-related tasks in educational contexts such as classification.
Resemblance Reporting on Children: Sisters Are More Proactive than Brothers
Authors: Fisktjønmo Guro Lovise Hole , Bårdsen Bård-Jørgen , Folstad Ivar 
Published: May 2022

AbstractThe asymmetric grandparental investment in humans may ultimately be explained by the paternity uncertainty hypothesis. The proximate mechanisms leading to grandparental bias in investment in grandchildren are, however, unclear. In a study of 233 males and females with an opposite sexed sibling, we examined whether comments on resemblance regarding one’s own child, or one’s sibling’s child, changed in frequency after both siblings became parents. We found that comments among siblings on resemblance of children occurred more frequently after both became parents, compared to when only one of the siblings had children, suggesting that resemblance descriptions may become more important after both siblings have children. Furthermore, and in line with the suggestion that mothers may mentally exploit the alloparenting environment by holding a stronger belief about resemblance, brothers reported that their sisters commented on resemblance concerning their own child more often and more intensely. Additionally, sisters corroborated this finding by self-reporting that they were the most proactive during resemblance descriptions of their brothers’ child. Thus, sisters might, through more frequent voicing of stronger opinions on parent–child resemblance than their brothers, influence alloparents’ perception of resemblance to their children and thus influence alloparental investments.
Continuous diameter increase reactor – a reactor concept for maximizing productivity by a controlled diameter extension
Authors: Hafner Marcus , Wolff Fabian , Roeder Thorsten 
Published: May 2022

AbstractThis paper presents a novel theoretical approach for maximizing productivity in microreactors by a controlled extension of the tube diameter. A one-dimensional numeric model was developed where the tube diameter increases based on the reaction heat to achieve a constant temperature throughout the reactor length. Through this approach, a basic plug flow reactor model for mass and heat transfer was used with an integrated algorithm for a controlled diameter extension. A parametric study was performed to ensure safe operating conditions concerning thermal runaway. The results show an increase in productivity of approximately 42% for the fictional second-order test reaction.
Graphical abstract
The role of K63-linked polyubiquitin in several types of autophagy
Authors: Dósa Anna , Csizmadia Tamás 
Published: May 2022

AbstractLysosomal-dependent self-degradative (autophagic) mechanisms are essential for the maintenance of normal homeostasis in all eukaryotic cells. Several types of such self-degradative and recycling pathways have been identified, based on how the cellular self material can incorporate into the lysosomal lumen. Ubiquitination, a well-known and frequently occurred posttranslational modification has essential role in all cell biological processes, thus in autophagy too. The second most common type of polyubiquitin chain is the K63-linked polyubiquitin, which strongly connects to some self-degradative mechanisms in the cells. In this review, we discuss the role of this type of polyubiquitin pattern in numerous autophagic processes.
Evaluation of ultra-high degree gravity field models: a case study of Eastern Tibetan Plateau and Sichuan Province
Authors: Yuan Huaqing , Wan Xiaoyun , Wu Yunlong , Peng Yi , Guo Zehua 
Published: May 2022

AbstractThis study validates the ultra-high-degree gravity field models in terms of the internal error estimate and the external precision. Internal error estimate is evaluated by geoid error degree variance and cumulative geoid height errors. The evaluation of the external precision is carried out using observed ground gravity data sets in Qinghai-Tibet Plateau and Sichuan Basin of mainland China. The results show that the geoid degree error is at the millimeter level, and the accumulated geoid error is at the centimeter level, and SGG-UGM-2 has the highest precision in terms of geoid errors. However, in terms of gravity anomaly, the GECO model has the highest precision of 37.080 mGal in the Qinghai-Tibet Plateau, and after terrain correction, its precision can reach 28.907 mGal, an improvement of 22%. In the Sichuan Basin, EGM2008 performs best with a precision of 7.202 mGal; the precision of EGM2008 becomes 6.648 mGal after terrain correction. These results mean that the terrain correction must be considered in the area where topography varies largely, while when the terrain is relatively flat, the effect of terrain on gravity can be ignored.
A Curve Approximation Approach Using Bio-inspired Polar Coordinate Bald Eagle Search Algorithm
Authors: Zhang Yunhui , Zhou Yongquan , Zhou Guo , Luo Qifang , Zhu Binwen 
Published: May 2022

AbstractIn this paper, a curve approximation approach using bio-inspired polar coordinate bald eagle search algorithm (PBES) is proposed. PBES algorithm is inspired by the spiral mechanism of bald eagle during predation. By introducing polar coordinate, the spiral predation process of the bald eagle will become more intuitive, which is more conducive for the algorithm to polar coordinate optimization problems. The initialization stage of PBES algorithm is modified to make the distribution of initialized individuals more uniform and some parameters are introduced to strengthen the exploration and exploitation capabilities of algorithm. The performance of the PBES algorithm is tested in three aspects: polar coordinate transcendental equation, curve approximation and robotic manipulator. The experimental results show that the PBES algorithm is superior to the well-known metaheuristic algorithms as it is effectively applicable for curve approximation problem.
The Broad Impacts of Disposable Lighter Safety Regulations
Authors: Viscusi W. Kip , Dalafave Rachel 
Published: May 2022

AbstractThe Consumer Product Safety Commission’s regulation of disposable lighters was targeted at preventing injuries due to use of lighters by children not over 4 years of age. Based on a difference-in-differences analysis of national data for 1990–2019, this article estimates that the regulation reduced all injuries to the target population by 71%, burn injuries by 74%, and injuries severe enough to warrant admission to the hospital by 85% overall and by 84% for burn injuries. Unlike the counterproductive performance of safety cap regulations, this safety device enhanced safety levels in the target population group. The safety improvements from lighter safety devices outweigh any lulling effect of viewing products as being “childproof.” The regulation had a broader safety impact beyond the target population group, as it also reduced all types of injuries by at least 50% for children in the 5–17 age groups. Total annual risk reduction benefits were $940–$1465 million. A benefit-cost analysis based on a retrospective assessment of the regulation finds a more favorable impact than was anticipated.
The effect of self-reported balance confidence on community integration after brain injury: an observational study
Authors: Tucker Jenna , Marshall Timothy , Beitscher Ilana , Mueller Kristina , Colucio Eric , Koc Thomas A. 
Published: May 2022

AbstractObjective:To evaluate the correlation between self-reported balance confidence and community integration related to home management for community-dwelling adults with acquired brain injury (ABI).Methods:This is a study of 141 participants over the age of 18 with a history of ABI, living in the community, who completed an online survey. The survey included a series of demographic questions followed by the Activities-Specific Balance Confidence Scale (ABC) and the Home Integration subscale of the Community Integration Questionnaire (CIQ-H).Results:Data from 119 completed surveys were included in the analysis. Significant positive correlations were found between the ABC and the CIQ-H total scores (rs = 0.241, p = 0.008). There was no significant difference between CIQ-H total scores in individuals by injury type (traumatic vs non-traumatic) or by level of severity (mild, moderate, severe) (p > 0.05). There was no significant difference between ABC total scores by injury type (p > 0.05).Conclusions:Higher levels of balance confidence may be associated with improved community integration related to home management for individuals with traumatic and non-traumatic BI. This study’s results support future research to evaluate the integration of strategies to improve balance confidence as a component of interdisciplinary assessment and rehabilitation to maximize community integration in community-dwelling adults with ABI.