bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mathematical modeling and projection of Vitamin D levels before and during COVID-19: A cross-sectional study including 86.772 samples
Authors: Arayici Mehmet Emin , Korkut-Uysal Sila Ovgu , Leblebici Asim , Akcali Zeynep , Edizer Deniz Tuna , Kabul Seher , Cimrin Dilek , Ellidokuz Ender Berat 
Published: July 2022

Abstract
Objective
Vitamin D (Vit-D) defined as a steroid hormone produced in the body by exposure of the human skin to UV (ultraviolet) B rays and has important roles in calcium and phosphorus metabolism as well as bone mineralization. In this study, it was aimed to examine Vit-D deficiency not only biologically but also mathematically and produce a mathematical model to determine the level of Vit-D as long as the COVID-19 measures continue.
Methods
In this study included 86.772 patients samples. Vit-D levels has a wave-curved form with stochasticity in essence. A mathematical modeling has been made for such a curve and this model has been defined. For describing the model MATLAB Curve fitting Toolbox has been used. SSE has been optimized by the Trust-Region algorithm where all the other parameters are selected as default.
Results
There is no significant difference between sexs according to Vit-D levels (p > .05). It was determined that Vit-D levels were significantly higher in the summer months and lower in the winter months (p < .001). When comparing the spring months, Vit-D levels in 2020 were found to be significantly lower than in 2019 (p < .001); on the contrary, when examined on the basis of summer, autumn, and winter months, it was determined that Vit-D levels increased in 2020 compared to 2019 (p < .001).
Conclusion
Restrictions, partial or complete closures, and curfews can significantly affect individuals' Vit-D levels during the COVID-19 outbreak. There is a need for multicenter studies with larger populations covering different regions to strengthen and support our results.
Triazine Dendrimers: An Excellent Drug Carrier for Improving the Solubility of Glyburide an Antidiabetic Agent
Authors: Malek MOHAMMED ABRAR H , Patel Pravinkumar M. 
Published: July 2022

Abstract
The intent of this work was to synthesized, develop and characterize a novel dendrimer and drug-dendrimer solutions to resolve poorly aqueous solubility of glyburide which is an antidiabetic BSC class-II drug’s problem. Drug- dendrimer complex formation is one of the widely reported method for solubility enhancement of the drug which can increase the efficiency of the drug. A number of glyburide drug solutions were formulated with different quantities of G1, G2 and G3 dendrimers via Higuchi and Connors method. The effects of pH, dendrimer concentration and generation of dendrimers (G1-G3) on the aqueous solubility of drug was investigated and characterized by FT-IR, NMR ( 1 H and 13 C). The experimental outcomes recommended that solubility of glyburide was significantly enhanced with the increasing concentration of dendrimers as well as the generations of dendrimers.
Single-center retrospective clinical evaluation of venetoclax combined with HMAs and half-dose CAG in the treatment of unfit or refractory/relapsed AML
Authors: Chen Xiaotong , Zhao Yanqiu , Li Qi , fan shengjin 
Published: July 2022

Abstract
Purpose The prognosis of unfit or relapsed/refractory (R/R) AML patients remains poor. Venetoclax has been proved to have anti-leukemia stem cell activity. However, there is little published information on the efficacy and safety of VEN combined with both demethylated drugs and half-dose chemotherapy in the treatment of unfit or R/R AML patients.Methods In this study, we retrospectively analyzed the clinical characteristics, treatment details, safety profile and clinical outcomes of unfit or R/R AML patients who were treated with VEN+ HMAs+ half-dose CAG.Results A total of 21 AML patients were involved in the study, 11 patients (52.4%) were in the unfit group, while 10 patients (47.6%) were in R/R group. FLT3 (6/21, 28.6%) was the most common gene aberration. Patients in the R/R group were found more likely to carry KIT (5/ 10, 50%) when compared to the unfit group (0/11, 0%) (P = 0.012). The median duration of CR+ CRi was 11.5 months (95% CI 8.9 to 14.1). Twelve patients achieved CR (57.1%), two CRi (9.5%), and three PR (14.3%), for an ORR 80.9% (17/21) and cCR 66.7% (14/21). CR was observed in 100% (5/5) AML patients with TP53, 80% (4/5) AML patients with IDH, 75% (3/4) AML patients with NPM1, 50% (3/6) AML patients with FLT3, 40% (2/5) AML patients with KIT, 40% (2/5) AML patients with DNMT3A, and 20% (1/5) AML patients with RUNX1. The most common AEs during VEN+ HMAs+ half-dose CAG therapy were persistent cytopenia, infection and gastrointestinal symptoms (decreased appetite, nausea, vomiting and diarrhea).Conclusion The results of this investigation show that VEN+ HMAs+ half-dose CAG demonstrated promising efficacy (even high-risk cytogenetics) and a tolerable safety profile in unfit or R/R AML patients.
Green Synthesis of Zinc Oxide Nanoparticles (ZnO-NPs) by Pterolobium hexapetalum (Roth) Santapau &amp; Wagh Aqueous Leaf Extract and Its Assessment of Biocompatible, Antibacterial, DPPH Radical Scavenging, Anticancer and Larvicidal Activities: An Effective Eco-Friendly Approach
Authors: Loganathan Settu , Manimaran Kumar , Mutamimurugan Karuvelan , Prakash Dhakshinamoorthy Gnana , Subashini Rajakannu 
Published: July 2022

Abstract
Pterolobium hexapetalum aqueous leaf extract (P. hexapetalum-ALE) was utilized as a reducing agent to synthesize zinc oxide nanoparticles (ZnO-NPs) and it’s forms of white precipitate. The synthesized P. hexapetalum - ZnO-NPs (Ph-ZnO-NPs) were characterized by UV-Vis, XRD, IR, EDAX, and HR-TEM with SAED pattern. UV-visible spectra results showed an absorbance peak at 280 and 370nm for Ph-ALE and synthesized Ph-ZnO-NPs. The HR-TEM result shows a spherical in shape with a size of 10-93 nm by Ph-ZnO-NPs. X-ray powder diffraction (P-XRD) spectra confirmed the crystalline nature of the synthesized ZnO-NPs. Hemolytic activity of the synthesized ZnO-NPs was carried out against Human RBCs and it’s found to be 0.6% at 100 µg/mL. The synthesized Ph-ZnO-NPs appeared excellent antibacterial and antioxidant activity against P. aeruginosa (17.8mm) and DPPH radical scavenging activity (IC50:118.14µg/mL). Ph-ZnO-NPs exposed superior anticancer activity against breast cancer cell line (MCF-7) with an IC50 value of 22.91 µg/mL. Additionally, the synthesized Ph-ZnO-NPs exhibited an excellent larvicidal activity with LC50 & LC90 values of 4.178 and 16.157 mg/mL on Cx. quinquefasciatus larvae at 24h inspection. Thus, plant-based synthesized Ph-ZnO-NPs exhibit significant biological activities, and hence it can be considered a potential source for the development of innovative drugs.
Desire and motivation for parenthood during the COVID-19 pandemic: A comparison of cis-gender minoritized sexual identities with cis-heterosexual individuals living in Germany
Authors: Batz Falk , Lermer Eva , Lech Sonia , O'Malley Grace , zehni Alaleh Zati , Zenz-Spitzweg Davina , Mahner Sven , Behr Joachim , Thaler Christian J. , Buspavanich Pichit 
Published: July 2022

Abstract
Background: The COVID-19 pandemic continues to spread across the globe and is associated with significant clinical and humanitarian burden. Indeed, the SARS-COV 2 virus has impacted on society asymmetrically: Marginalized social minority groups, such as individuals who do not exclusively sexually identify as heterosexual, represent a vulnerable population in the context of the COVID-19 pandemic. While higher rates of anxiety and depression have been reported in individuals with minoritized sexual identities (compared to heterosexual individuals) during the COVID-19 pandemic, the specific impact of the pandemic and its social restriction measures on this population is poorly understood.Methods: From April to July 2020, we conducted an anonymous cross-sectional survey online among N = 2463 adults living in Germany. We screened for depressive symptoms (Patient Health Questionnaire-4; PHQ-4) and assessed individuals’ desire for parenthood during the pandemic, and motives for or against the desire for parenthood (Leipzig questionnaire on motives for having a child, Version 20; LKM-20), with the aim of identifying differences between individuals with minoritized sexual identities and heterosexual individuals. Results: Compared to heterosexual individuals (n = 1304), individuals with minoritized sexual identities (n = 831) indicated higher levels of depressive symptoms. In our study sample the majority of all participants’ (81.9%) reported no change in the desire for parenthood since the COVID-19 pandemic. The ranking of the motives for parenthood did not change since the pandemic in heterosexuals and individuals with minoritized sexual identities. Nevertheless, both subgroups scored lower in all motives compared to the time before the pandemic. Conclusions: The findings underline the unmet need for social, psychological and medical support in regard to family planning and the desire for parenthood during the pandemic. Furthermore, future research should explore COVID-19-related psychological consequences on individuals’ desire for parenthood and building a family.
Immunodominance of epitopes and protection efficacy of RBD antigen are differentially altered by different adjuvants and immune pathways
Authors: Li Sisi , Duan Lianli , Zhang Xiaoli , yang Rui , Chen Longlong , Chen Zhifu , Gou Qiang , Bao Wenxin , Yuan Yue , Jing Haiming , zhang Yi , Cheng Ping , Luo Ping , Zou Quanming , Wang Wanneng , Zhao Zhuo 
Published: July 2022

Abstract
Purpose
Previous studies have revealed that the receptor-binding domain (RBD) of the spike protein is immunogenic in both mice and healthy volunteers, and the humoral immune response plays key roles in RBD-mediated protection. In this study, we evaluated the immunodominant humoral response of RBD with different adjuvants and different immune routes in inducing neutralizing antibodies and immunodominant epitopes in RBD.
Methods
In this study, we investigated the protective efficacy of immunization with RBD plus three different adjuvants (Al(OH)3, ASO3 or AddaVax) and two different routes (intramuscular immunity or intranasal immunity) in a mouse model.
Results
The results showed that RBD-mediated protection was altered in response to different adjuvants; even with the same adjuvant, RBD-mediated protection was altered in different immune routes. Using antisera from immunized mice, we identified six B-cell immunodominant epitopes in the RBD, including 2 novel epitopes (RBD1 − 18 and RBD49 − 66) in intramuscular immunity and 3 novel epitopes (RBD31 − 48, RBD61 − 78, RBD97 − 114) in intranasal immunity. The B-cell immunodominant epitopes identified from mice immunized with RBD plus different adjuvants were also different from each other, which may explain the differences in protective immunity observed in each immunized group.
Conclusions
This study indicate that adjuvants and immune pathways largely affect the immunodominance of epitopes and the protective efficacy of RBD, which may guide further adjuvant screening for vaccine development and optimization.
Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus
Authors: Kim Dong-Hwi , Han Sang-Hoon , Go Hyeon-Jeong , Kim Da-Yoon , Kim Jae-Hyeong , Lee Joong-Bok , Park Seung-Yong , Song Chang-Seon , Lee Sang-Won , Choi In-Soo 
Published: July 2022

Abstract
Canine coronavirus (CCoV), canine parvovirus (CPV), and canine distemper virus (CDV) are highly contagious canine pathogens; dogs with these diseases are difficult to treat. In a previous study, we developed a recombinant adenovirus expressing canine interferon lambda 3 (Ad-caIFNλ3) in canine epithelial cells. This study aimed at investigating the antiviral activity of Ad-caIFNλ3 against CCoV, CPV, and CDV in two canine cell lines, A72 and MDCK. Ad-caIFNλ3 transduction suppressed replication of these viruses without cytotoxicity. These results suggested that Ad-caIFNλ3 may be a therapeutic candidate for canine viral diseases.
Impact of marital status at diagnosis on overall survival in patients with anal canal squamous cell carcinoma: a propensity score-matched analysis
Authors: Yang Ting , Xiao Hongqi , Sun Fei , Guo Xinggang 
Published: July 2022

Abstract
Purpose
Marital status has been shown to be an important psychosocial factor that plays an important role in the prognosis of various cancers. The effect of marital status on survival outcomes in anal canal squamous cell carcinoma has not been studied. The purpose of this study was to investigate the effect of marital status on overall survival in anal canal squamous cell carcinoma.
Methods
According to the established screening criteria, we obtained 2441 patients with anal canal squamous cell carcinoma from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier analysis and multivariate Cox regression analysis were used to analyze the overall survival of anal canal squamous cell carcinoma patients with different marital status. 1:1 propensity score matching (PSM) was used to match 888 unmarried patients with 888 married patients to further demonstrate the effect of marital status on overall survival in patients with anal canal squamous cell carcinoma.
Results
The 5-year overall survival rates of married, separated/divorced, single and widowed patients with anal canal squamous cell carcinoma were 75.6%, 69.4%, 62.1%and 51.5%, respectively. Multivariate Cox regression analysis indicated that being married was a protective factor for overall survival among anal canal squamous cell carcinoma patients (Divorced/Separated: HR, 1.27; 95% CI, 1.06–1.54; P = 0.012; Single: HR, 1.31; 95% CI, 1.10–1.55; P = 0.002; widowed: HR, 1.82; 95% CI, 1.48–2.23; P < 0.001). Furthermore, married patients were found to have better overall survival than unmarried patients both before and after propensity score matching.
Conclusion
This study found that married patients with anal canal squamous cell carcinoma had better survival outcomes, while widowed patients had the worst overall survival.
Monkeypox virus and the safety margins of plasma-derived medicinal products
Authors: Kindermann Johanna , Karbiener Michael , Kreil Thomas R. 
Published: July 2022

Abstract
The currently ongoing outbreak of Monkeypox virus in many non-endemic countries around the world has also raised concerns about the safety of plasma-derived medicinal products. Based on what is known about the poxvirus family, i.e., that members are exceedingly large and carry a lipid envelope, effective removal and inactivation by plasma product manufacturing processes is expected. For the widely used solvent-detergent treatments, however, poxviruses have been reported as potentially being a bit more resistant. The current investigation sought to verify poxvirus inactivation by Triton X-100-based solvent-detergent treatment. For vaccinia virus, a model closely resembling monkeypox virus, we measured fast inactivation to the assay detection limit, i.e., reduction of infectivity greater than 4 log10 within 10–20 min. As use of Triton X-100 will, based on environmental concern around its release, be restricted, a physicochemically virtually identical alternative, Nereid, was also tested, and found fully equivalent.
Experiments Exploring Mystery of Double Slit --- Utilizing Photon Chamber
Authors: peng hui 
Published: July 2022

Abstract

Young’s double slit experiments, which represent the mystery of quantum mechanics, have been described by the optic wave theory, the electromagnetic wave (EM wave) theory and pilot wave theory. Recently, the coexistence of the particle nature and the wave distribution of light in double slit experiments has been confirmed. In this article we utilize the photon chamber to detect the traces of the light beam in the double slit experiments, namely to visualize the particle nature of the light beam. The existence of the light tracks indicates the particle nature of the light beam in the wave experiments.Furthermore, the two sides of the chamber are covered by copper foil for shielding the EM wave. If the light were the EM waves, then the interference pattern would be disturbed. The experiments show that the light behave as particles moving through the photon chamber. The double slit photon chamber experiments challenge the optic wave theory, EM wave theory, but support the pilot wave theory at far field. The photon chamber is very inexpensive and may be used to study the nature of the light.
Modeling Infragravity Wave Runup and Spectral Properties
Authors: Montoya Luis , Lynett Patrick 
Published: July 2022

Abstract

The purpose of this study is twofold: (1) to establish a method to model infragravity (IG) waves and their runup using a nonlinear, phase-resolving Boussinesq-type numerical model (COULWAVE) and (2) to discuss possible sources of error/convergence issues when modeling IG runup. To establish a method of modeling IG waves, runup height predictions were first compared between COULWAVE and the Stockdon (2006) empirical equation and good agreement was found (R2 = 0.951). This study shows the importance of the spectral frequency resolution when studying IG runup. Numerically convergent runup distributions were found using a frequency resolution of 10-4 Hz; this is more than 100 times smaller than what is typically used in coastal phase-resolving models. To determine a statistically convergent infragravity (0-0.02Hz) spectrum, around 30 different phase realizations are needed with either a reef or planar beach configuration, for the wave heights and periods studied here. A methodology is presented on how to address numerical domain resonance and sponge layer performance.
Design of a 3.2 mW Differential Ring VCO with Wide Tuning-Range using Self Biased Active Inductor Topology in 180 nm CMOS process
Authors: Kumar Nitin , Kumar Manoj , SINGH VIKRAM 
Published: July 2022

Abstract
This paper reports a design of the most significant electronic circuit used in modern wireless and optical communications systems, known as voltage-controlled oscillator (VCO). A variable delay stage is a core element of ring VCO and in this work, a new differential delay stage based on the inductive shunt peaking technique using active inductors (AI) is presented to increase the ring VCO’s frequency bandwidth. The presented four-stage ring VCO architecture with a new differential delay stage utilizes the dual delay path scheme to achieve high oscillation frequency, low power dissipation, and low phase noise. The proposed VCO circuit is designed and simulated in a 180 nm TSMC CMOS process and 1.8 V supply voltage (Vdd). The VCO generates an output frequency range from 2.876 GHz to 2.039 GHz (34.05%) for 0 V to 1 V variation in control voltage (Vc). The designed VCO circuit's power dissipation ranges from 3.289 mW to 2.888 mW, and its phase-noise at 1 MHz offset frequency is -108.9 dBc/Hz. The VCO exhibits figure of merit is -171.9 dBc/Hz and a layout area of 1148.67 µm2.
Trends in the Prevalence of Chronic Medication Use Among Children in Israel Between 2010 and 2019: Protocol for a Retrospective Cohort Study
Authors: Sadaka Yair , Horwitz Dana , Wolff Leor , Sela Tomer , Meyerovitch Joseph , Peleg Assaf , Bachmat Eitan , Benis Arriel 
Published: July 2022

Background
Prescription of psychostimulants has significantly increased in most countries worldwide for both preschool and school-aged children. Understanding the trends of chronic medication use among children in different age groups and from different sociodemographic backgrounds is essential. It is essential to distinguish between selected therapy areas to help decision-makers evaluate not only the relevant expected medication costs but also the specific services related to these areas.

Objective
This study will analyze differences in trends regarding medications considered psychobehavioral treatments and medications considered nonpsychobehavioral treatments and will identify risk factors and predictors for chronic medication use among children.

Methods
This is a retrospective study. Data will be extracted from the Clalit Health Services data warehouse. For each year between 2010 and 2019, there are approximately 1,500,000 children aged 0-18 years. All medication classes will be identiﬁed using the Anatomical Therapeutic Chemical code. A time-trend analysis will be performed to investigate if there is a significant difference between the trends of children’s psychobehavioral and nonpsychobehavioral medication prescriptions. A logistic regression combined with machine learning models will be developed to identify variables that may increase the risk for specific chronic medication types and identify children likely to get such treatment.

Results
The project was funded in 2019. Data analysis is currently underway, and the results are expected to be submitted for publication in 2022. Understanding trends regarding medications considered psychobehavioral treatments and medications considered nonpsychobehavioral treatments will support the identification of risk factors and predictors for chronic medication use among children.

Conclusions
Analyzing the response of the patient (and their parents or caregivers) population over time will hopefully help improve policies for prescriptions and follow-up of chronic treatments in children.

International Registered Report Identifier (IRRID)
DERR1-10.2196/36756