bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetite‐doped electrospun fibers forDNAadsorption
Authors: Cavalcante Edmo Henrique Martins , de Oliveira Helinando Pequeno 
Published: October 2022

AbstractGene delivery, biosensing‐based diagnostic therapy, and in vivo responsive drugs are promising technologies based on the interaction of DNA with supports on the nanoscale. Typical advantages for nanomaterials applied in DNA removal are related to their high surface area and availability of cationic sites that favor the electrostatic interaction with the target (DNA). Herein, a magnetite‐doped cationic polymer was explored as a support for the production of electrospun fibers that offer an abundance of the available sites for the adsorption of DNA while exploring the doping effect of magnetite for the improvement in the adsorption capacity and the magnetic removal from the reactor. The mechanisms of adsorption revealed that the Freundlich isotherm prevails in a process denoted by the pseudo‐second‐order kinetic model.
Alloying synergistic flame retardant effect improving fire resistance and mechanical properties of polyamide 6
Authors: Li Junxiao , Qian Lijun , Xi Wang , Qiu Yong , Tang Wei , Li Shanzhe 
Published: October 2022

AbstractThe alloying synergistic flame retardant effect was studied by using polyetherimide (PEI) and aluminum diethylphosphinate (ADP) for polyamide 6 (PA6), which can endow PA6 composites with excellent mechanical properties and flame retardancy simultaneously. On the one hand, because the molecular structures of PEI and PA6 are similar, adding PEI with PA6 can form PEI‐PA6 alloy by the hydrogen bond effect and nice homogeneous phase, which can endow PA6 composites with excellent mechanical properties. On the other hand, the test results of flame retardancy show that 9ADP/10PEI‐PA6 composite can obtain higher LOI value (LOI = 31%), and excellent flame retardant rating (UL94 V‐0) with 9%ADP and 10%PEI. From the results of cone calorimetry test, the pk‐HRR and THR of 9ADP/10PEI‐PA6 are reduced by 24.4% and 24.7%, respectively, compared to PA6, and higher char residue rate was obtained, which shows that ADP combined with PEI‐PA6 alloying exerts an excellent flame retardant synergistic effect. Through the study of flame retardant mechanism found that ADP works together with PEI can effectively increase the quenching effect in the gas phase, promote thermal stability, and delay the decomposition process of PA6 matrix during the combustion process. Meanwhile, it also increases the char yield to exert a synergistic effect in the condensed phase by ADP/PEI‐PA6. The residual char rate reached 36.6%, higher than neat PA6 about 4.6 wt.%. Thus, the alloying flame retardant method using ADP/PEI‐PA6 can endow PA6 with better flame retardancy and more excellent mechanical properties. Importantly, it provides a new direction for developing high‐performance halogen‐free flame retardant materials.
Techno‐Economic assessment for superactive carbon production from side stream lignin
Authors: Ponomarev Nikolai P. , O'Shea Gregory , Nuortila‐Jokinen Jutta , Kiljunen Samantha , Kallioinen‐Mänttäri Mari 
Published: October 2022

AbstractSuperactive carbon (SAC), having a high surface area of over 2500 m2/g, could be a superior choice for many applications. However, the manufacture of SAC in bulk quantities is challenging. To demonstrate the possibility of SAC manufacturing in large amounts, a techno‐economic assessment was performed. For that purpose, a new method utilizing a mixture of waste lignin, KOH and KCl was employed. The chemicals were recovered after use. The technical assessment was performed based on laboratory‐scale experimental findings, a simplified process diagram, and mass and heat balance calculations. The economic evaluation was assessed through the estimation of capital costs (CAPEX), operational costs (OPEX) and the minimum selling price (MSP). Moreover, to demonstrate the potential costs saving for the water treatment process, the performance of SAC for the removal of natural organic matter was compared with that of commercial active carbon. SAC was obtained at a minimized KOH amount (1 g/g) and chemicals were successfully recovered with a rate of 5–10% losses. The CAPEX, OPEX and MSP were found to be 4–21 million EUR, 1–9 million EUR/year and 4.4–2.9 kEUR/t for a 0.5–5.0 t/year production capacity, respectively, at a profitability requirement of 20% and a less than 5 year payback period. In addition, SAC demonstrated considerably higher adsorptive capacity for natural organic matter (600–900 mg total organic carbon/g) compared with commercial active carbon (40–50 mg total organic carbon/g), which could lead to substantial process savings. SAC manufacture through this method has been validated and the benefit for the potential application is sufficiently clear to promote the successful commercialization of SAC using lignin wastes. © 2022 The Authors. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd.
The ligamentum mucosum: A new classification
Authors: Gonera Bartosz , Kurtys Konrad , Wysiadecki Grzegorz , Podgórski Michał , Olewnik Łukasz Hubert 
Published: October 2022

AbstractThe ligamentum mucosum (LM) is a ligamentous structure within the synovial layer of the knee joint capsule. For a long time LM was perceived as the vestigial remnant from the embryological development of the knee. However, last years have shown increased interest in this structure due to its potentially significant clinical role. Fifty‐one, 12 females (mean age 83.1 ± 3.4 years) and 39 males (mean age 84.2 ± 6.8 years) fixed in 10% formalin were examined. Upon dissection, the following morphological features of the LM were assessed: the types of LM, morphometric measurement and histological analysis of each type. The LM was present in 66.7% of all examined specimens. Three different types were recognized: Type I (55.9%)—single band with attachment to the intercondylar notch, Type IIa—bifurcated ligament with attachment to the anterior cruciate ligament, Type IIb—bifurcated ligament with both attachments to the intercondylar notch, Type III—double ligament with two independent bands and attachments to the intercondylar notch and to the knee joint capsule. The LM is variable and probably evolutionary changes are the reason. In our study we propose the new clinically useful classification supported by its anatomical and histological characteristics. Type IIa seems to be the most important from the clinical point of view, as it may be responsible for clinical issues and should be paid attention while diagnosing patients suffering from anterior cruciate ligament torn or anterior knee pain.
Aldehyde dehydrogenase 2 polymorphism is associated with chemotherapy‐related cognitive impairment in patients with breast cancer who receive chemotherapy
Authors: Yao Senbang , Li Wen , Liu Shaochun , Cai Yinlian , Zhang Qianqian , Tang Lingxue , Yu Sheng , Jing Yanyan , Yin Xiangxiang , Cheng Huaidong 
Published: October 2022

AbstractBackgroundChemotherapy‐related cognitive impairment (CRCI) is a common but easily overlooked condition that markedly affects the quality of life (QOL) of patients with breast cancer. The rs671 is a common gene polymorphism of aldehyde dehydrogenase 2 (ALDH2) in Asia that is involved in aldehyde metabolism and may be closely related to CRCI. However, no study has yet summarised the association between ALDH2 and CRCI.MethodsThis study enrolled one hundred and twenty‐four patients diagnosed with breast cancer according to the pathology results, genotyped for ALDH2 single‐nucleotide polymorphisms (SNP) to explore these. The mini‐mental state exam (MMSE), verbal fluency test (VFT), and digit span test (DST) results were compared in these patients before and after chemotherapy (CT).ResultsWe found that patients with ALDH2 gene genotypes of rs671_GG, rs886205_GG, rs4648328_CC, and rs4767944_TT polymorphisms were more likely to suffer from cognitive impairment during chemotherapy. A trend toward statistical significance was observed for rs671_GG of DST (z = 2.769, p = 0.006), VFT (t = 4.624, P<0.001); rs886205_GG of DST (z = 3.663, P<0.001); rs4648328_CC of DST (z = 2.850, p = 0.004), VFT (t = 3.477, p = 0.001); and rs4767944_TT of DST (z = 2.967, p = 0.003), VFT (t = 2.776, p = 0.008). The cognitive indicators of these patients significantly decreased after chemotherapy (p < 0.05). The difference in ALDH2 rs671 was most obvious.ConclusionOur results showed what kinds of ALDH2 genotyped patients that are more likely to develop CRCI. In the future, it may be possible to infer the risk of CRCI by detecting the single‐nucleotide locus of ALDH2 that is conducive to strengthening clinical interventions for these patients and improving their QOL. More importantly, this study has important implications for Asian women with breast cancer as ALDH2 rs671 is a common polymorphism in Asians.
In Silico Identification of Potential Insect Peptides against Biofilm‐Producing Staphylococcus aureus
Authors: Sahoo Alaka , Swain Shasank S. , Panda Sujogya K. , Hussain Tahziba , Panda Maitreyee , Rodrigues Célia F. 
Published: October 2022

AbstractBiofilm‐producing Staphylococcus aureus (SA) strains are frequently found in medical environments, from surgical/ wound sites, medical devices. These biofilms reduce the efficacy of applied antibiotics during the treatment of several infections, such as cystic fibrosis, endocarditis, or urinary tract infections. Thus, the development of potential therapeutic agents to destroy the extra protective biofilm layers or to inhibit the biofilm‐producing enzymes is urgently needed. Advanced and cost‐effective bioinformatics tools are advantageous in locating and speeding up the selection of antibiofilm candidates. Based on the potential drug characteristics, we have selected one‐hundred thirty‐three antibacterial peptides derived from insects to assess for their antibiofilm potency via molecular docking against five putative biofilm formation and regulated target enzymes: the staphylococcal accessory regulator A or SarA (PDB ID: 2FRH), 4,4′‐diapophytoene synthase or CrtM (PDB ID: 2ZCQ), clumping factor A or ClfA (PDB ID: 1N67) and serine‐aspartate repeat protein C or SdrC (PDB ID: 6LXH) and sortase A or SrtA (PDB ID: 1T2W) of SA bacterium. In this study, molecular docking was performed using HPEPDOCK and HDOCK servers, and molecular interactions were examined using BIOVIA Discovery Studio Visualizer‐2019. The docking score (kcal/mol) range of five promising antibiofilm peptides against five targets was recorded as follows: diptericin A (−215.52 to −303.31), defensin (−201.11 to −301.92), imcroporin (−212.08 to −287.64), mucroporin (−228.72 to −286.76), apidaecin II (−203.90 to −280.20). Among these five, imcroporin and mucroporin were 13 % each, while defensin contained only 1 % of positive net charged residues (Arg+Lys) projected through ProtParam and NetWheels tools. Similarly, imcroporin, mucroporin and apidaecin II were 50 %, while defensin carried 21.05 % of hydrophobic residues predicted by the tool PEPTIDE. 2.0. Most of the peptides exhibited potential characteristics to inhibit S. aureus‐biofilm formation via disrupting the cell membrane and cytoplasmic integrity. In summary, the proposed hypothesis can be considered a cost‐effective platform for selecting the most promising bioactive drug candidates within a limited timeframe with a greater chance of success in experimental and clinical studies.
Seasonal Variation in the Essential Oil Yield and Composition of Cinnamomum parthenoxylon (Jack) Meisner
Authors: Qiu Fengying , Zhang Ting , Zhou Songsong 
Published: October 2022

AbstractCinnamomum parthenoxylon (Jack) Meisner is an important natural aromatic plant because its leaves are rich in essential oil. Linalool chemotype C. parthenoxylon was used as the research material in the present study. The leaf essential oil yield, the main chemical components, and their content were measured every month from January to December 2018 to study the seasonal variation in the yield and chemical components of C. parthenoxylon leaf essential oil. The results revealed that the essential oil yield and the main chemical component linalool in the essential oil of C. parthenoxylon leaves showed significant differences among months. The leaf essential oil yield and linalool content decreased to the lowest in March and increased rapidly from April to May. The leaf essential oil yield was the highest in May, and a relatively high yield was maintained from April to August. The linalool content in leaf essential oil was stable in other months except March. The leaf essential oil yield of C. parthenoxylon had a very significant positive correlation with monthly rainfall and monthly average temperature. Intense rainfall and high monthly average temperature were conducive to the synthesis and accumulation of C. parthenoxylon leaf essential oil. This study provided a theoretical basis for cultivating C. parthenoxylon as a raw material for spices and determining the best harvest time.
Opportunities to increase whole grain intake within the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC)
Authors: Slavin Joanne L. , Sanders Lisa M. , Stallings Virginia A. 
Published: October 2022

AbstractBackground: In 2017, the National Academies of Science, Engineering, and Medicine, at the request of the United States Department of Agriculture Food and Nutrition Service (USDA FNS), published an expert report proposing updates to food packages for the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). Recommendations included adoption of the “whole grain‐rich” criteria instead of the whole grain health claim to classify whole grain breakfast cereals, and further, that all breakfast cereals be whole grain‐rich. Aims & Methods: To discuss the advantages and implications of these recommendations, the Cereal & Grains Association, in partnership with General Mills, Inc., convened an expert roundtable in April 2022. Results & Discussion: The roundtable agreed increasing whole grain intake among WIC participants is critical and adoption of the whole grain‐rich criteria aligns with the 2020 Dietary Guidelines for Americans and child nutrition programs. However, potential challenges in requiring all cereals to be whole grain‐rich, including cost, and consumer choices based on taste and cultural preferences were noted and potential solutions discussed. Conclusion: Considering the public health need to increase whole grain intake, USDA FNS should increase the provision of whole grain in WIC food packages, while also considering the preferences of WIC participants and food costs.
MALT lymphoma of the sublingual gland: A case report with current overview of diagnostic and therapeutic strategies
Authors: Ono Shoya , Goto Mitsuo , Miyabe Satoru , Makihara Hiroyuki , Kubo Katsutoshi , Nagao Toru 
Published: October 2022

AbstractExtranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue (MALT) is a low‐grade B‐cell lymphoma. MALT lymphomas involving the sublingual gland are extremely rare. Herein, we report a case of MALT lymphoma of the sublingual gland. Additionally, we discuss challenging diagnostic aspects as well as current treatment strategies.
Cricohyoidoepiglottopexy in an emergency scenario: Evaluation and management of a severe laryngeal trauma
Authors: Laora Andrea Di , Capitaine Anne‐Laure , Lacour Mathilde , Trijolet Jean‐Paul 
Published: October 2022

AbstractWe describe the clinical evaluation and the management of a severe laryngeal trauma in a suicidal patient. We aim to demonstrate how the cricohyoidoepiglottopexy, which is a surgical technique mainly performed for oncological purposes, can be successfully used in this emergency setting.
Continuous Flow Single‐Atom Catalysis: A Viable Organic Process Technology?**
Authors: Pagliaro Mario , Della Pina Cristina , Ciriminna Rosaria 
Published: October 2022

AbstractHeterogeneous catalysis under continuous flow conditions is increasingly used by the chemical industry to synthesize fine chemicals. Is single‐atom catalysis under flow a technically and economically viable organic process technology? Early results suggest valuable insight en route to the industrial uptake of single‐atom catalysis in the production of fine and specialty chemicals.
Brønsted‐Acid‐Catalyzed One‐Pot Synthesis of β,β‐Diaryl Esters: Direct Regioselective Approach to Diverse Arrays of 3‐Aryl‐1‐indanone Cores
Authors: Sharma Pragya , Taneja Neha , Singh Sanjay , Hazra Chinmoy K. 
Published: October 2022

AbstractA three‐component, solvent‐dependent, Brønsted‐acid‐catalyzed reaction of benzaldehydes, silyl enolates and arene nucleophiles has been developed for the synthesis of potential drug candidate 3‐aryl‐1‐indanones. This reaction features the formation of three C−C bonds, high regioselectivity in a one‐pot strategy, broad substrate generality, facile scalability (1.04g), high functional group tolerance and viable substrates. The β‐O‐silyl ethers generated in‐situ from the Mukaiyama aldol reaction were subjected to acid‐catalyzed benzylic arylation with strong as well as weak nucleophiles, and the resultant β,β‐diaryl esters can undergo a third C−C bond formation with excellent regioselectivity through intramolecular cyclization to afford the indanone products in the same pot. Detailed mechanistic insight leads to a feasible reaction pathway. This transformation opens up a practical and adaptable approach to producing a variety of synthetically valuable transformations and enable the synthesis of medicinally valuable (R)‐tolterodine and (+)‐indatraline.
Effect of operating factors on liquid–liquid mass transfer and dispersion pattern of sedimentary liquid in a mechanically stirred vessel
Authors: Sunami Koudai , Horiuchi Shuhei , Nishimura Noriko , Uddin Md. Azhar , Kato Yoshiei 
Published: October 2022

AbstractLiquid–liquid dispersion and mass transfer were investigated in mechanically stirred vessels without baffles by changing operation factors such as an impeller rotation speed, off‐bottom clearance, volumetric liquid ratio, etc. The dispersion regime was categorized into five groups: the sedimentary liquid was kept at the vessel bottom (I), partially elevated without any collision (II), partially dispersed by colliding with the impeller bottom (III), both liquids were partially dispersed by collisions with impeller blades (III’), and the sedimentary liquid was completely dispersed (IV). The dispersion switched to I → II → III → IV with the increasing rotation speed and decreasing off‐bottom clearance. The liquid–liquid mass transfer rate was significantly enhanced with the collision of the sedimentary liquid with the impeller bottom, and subsequently increased with the increasing rotation speed, volumetric liquid ratio, and vessel diameter and with the decreasing off‐bottom clearance. A multiple regression analysis method was applied to determine the mass transfer rates of III and III’.
Determination of ERG(+), EZH2, NKX3.1, and SPINK‐1 subtypes to evaluate their association with clonal origin and disease progression in multifocal prostate cancer
Authors: Segura‐Moreno Yenifer Yamile , Sanabria‐Salas María Carolina , Mesa‐López De Mesa Jorge Andrés , Varela‐Ramirez Rodolfo , Acosta‐Vega Natalia Lizeth , Serrano Martha Lucía 
Published: October 2022

AbstractBackgroundThe prognostic relevance of prostate cancer (PCa) molecular subtypes remains controversial, given the presence of multiple foci with the possibility of different subtypes in the same patient.AimTo determine the clonal origin of heterogeneity in PCa and its association with disease progression, SPOP, ERG(+), EZH2, NKX3.1, and SPINK‐1 subtypes were analyzed.MethodsA total of 103 samples from 20 PCa patients were analyzed; foci of adjacent non‐tumor prostate tissue, HGPIN, GL3, GL4, GL5, and LN were examined to determine the presence of the TMPRSS2‐ERG fusion and ERG, EZH2, NKX3.1, and SPINK‐1 expression levels, using RT‐PCR. Mutations in exons 6 and 7 of the SPOP gene were determined by sequencing. The presence of subtypes and molecular patterns were identified by combining all subtypes analyzed. To establish the clonal origin of multifocal PCa, molecular concordance between different foci of the same patient was determined. Association of these subtypes with histopathological groups and time to biochemical recurrence (BCR) was assessed.ResultsNo mutation was found in SPOP in any sample. The ERG(+) subtype was the most frequent. The molecular pattern containing all four PCa subtypes was only detected in 3 samples (4%), all LN, but it was the most frequent (40%) in patients. Molecular discordance was the predominant status (55%) when all analyzed molecular characteristics were considered. It was possible to find all subtypes, starting as a preneoplastic lesion, and all but one LN molecular subtype were ERG(+) and NKX3.1 subtypes. Only the expression of the NKX3.1 gene was significantly different among the histopathological groups. No association was found between BCR time in patients and molecular subtypes or molecular concordance or between clinicopathological characteristics and molecular subtypes of ERG, EZH2, and SPINK‐1.ConclusionThe predominance of molecular discordance in prostatic foci per patient, which reflects the multifocal origin of PCa foci, highlights the importance of analyzing multiple samples to establish the prognostic and therapeutic relevance of molecular subtypes in a patient. All the subtypes analyzed here are of early onset, starting from preneoplastic lesions. NKX3.1 gene expression is the only molecular characteristic that shows a progression pattern by sample.
Hybrid optimized query expansion strategy for semantic information retrieval using spatial bound whale and binary moth flame optimization algorithm
Authors: Kumar Ram , Sharma S. C. 
Published: October 2022

SummaryThe standard information retrieval systems mainly extract documents based on the relative keywords and this method is not effective since the related information can be only identified by extracting the semantics present in the text. Hence to overcome this problem, a semantic‐based query retrieval model is formulated in this article for query processing, identification, extraction, expansion, sorting, and filtering. A keyword expansion approach using the hybrid spatial bound whale optimization algorithm‐binary moth flame optimization algorithm is proposed in this work. In this way, the complexity associated with insufficient query information is overcome. The efficiency of the proposed model in extracting the top k relevant information is evaluated using the experiments conducted in the TREC data using different performance metrics such as precision@k, recall@k, mean reciprocal rank@k, mean average precision, and normalized discounted cumulative gain (NDCG@k). The proposed model achieves improved outcomes when compared to different state‐of‐art techniques such as i‐Dataquest, fuzzy logic, ontological framework for information extraction, and personal knowledge management in terms of precision@k, recall@k, mean reciprocal rank@k, exact match, F1‐score, and NDCG@k. The proposed model gives a mean reciprocal rank@k score of 0.8901, 0.8947, 0.8958, and 0.9014 for the k‐values 1, 3, 5, and 10, respectively. The MAP@k score for the top‐10 result suggestion retrieved is 0.39056. The exact match score of the proposed model for the newsgroup, SQuAD 1.0, and SQUAD 2.0 is 93.25, 94.65, and 95.25.