bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Combined Pure Cultures of Rhizopus sp. (Rhizopus oryzae,
Rhizopus oligosporus, and Rhizopus stolonifer) on Tempeh Extract Yogurt
as a Functional Food
Authors: Yarlina Vira Putri , Astuti Dea Indriani , Djali Mohammad , Andoyo Robi , Lani Mohd Nizam 
Published: March 2022

Background:
Tempeh Extract Yogurt was an alternative to tempeh product development that can be used as a functional product. This study aimed to determine the functional food potential of yogurt with tempeh extract by including tempeh using mixed cultures.

Methods:
The ratio of making tempeh Rhizopus oryzae, Rhizopus oligosporus, Rhizopus stolonifer inoculum of 1:1:1, 1:2:1, 2:1:2, 1:1:2, 2:1:1, respectively; RAPRIMA tempeh starter as a control group was fermented with Lactic Acid Bacteria to produce tempeh extract yogurt.

Results:
Tempeh extract yogurt by SNI 2891:2009 with the characteristic’s thick liquid, specific aroma, sour taste, and homogeneous consistency. The highest form of vitamin B12 and folate in Tempeh Extract Yogurt was on a 1:2:1 ratio (0.072 g/100 mL and 0.059 g/100 mL), and the genistein isoflavone in RAPRIMA was 3.669 g/100 mL with a pH value of 4.2 and a total bacterium of 14,3 x 108 CFU/mL.

Conclusion:
Tempeh extract yogurt contains several vitamin B12, folate, isoflavones, and total bacteria Tempeh Extract Yogurt be responsible as a functional food.
Maternal Nutritional Factors, Fetal Macrosomia and Increased Risk of
Childhood Obesity: Effects of Excess Placental Transfer of Maternal
Glucose and Fatty Acids
Authors: Kabaran Seray 
Published: March 2022

Background:
Maternal nutritional factors play a significant role in maternal glucose
and fatty acid transfer across the placenta and contribute to further enhancing fetal growth and
also increasing the risk of fetal macrosomia.

Objective:
This review aims to provide the effects of placental transfer of maternal fatty acids
and glucose on fetal macrosomia, and also highlights the maternal nutritional interventions to
prevent fetal adiposity.

Method:
All abstracts and full-text articles have been examined and the most relevant articles
have been included in this review.

Results:
Maternal obesity, maternal over-nutrition, and gestational diabetes can permanently influence
the risk of macrosomia via the effects of the placental transfer of maternal fatty acids and
glucose on the fetus. These conditions are associated with unfavorable maternal environments
that lead to fetal growth acceleration by adverse fetal programming outcomes and increased risk
of childhood obesity. As a result, pregnancy should be viewed as a window of opportunity for
the development of maternal nutritional therapies that improve maternal glucose and lipid metabolism,
potentially reducing macrosomia and juvenile obesity.

Conclusion:
Evidence-based techniques for managing maternal glucose and fatty acid transfer to
the fetus include maintaining maternal pre-pregnancy body mass index (BMI), acceptable weight
gain throughout pregnancy, and maternal nutritional interventions during pregnancy. Healthy
dietary patterns (such as the Mediterranean diet) and/or dietary consumption of certain nutrients
(such as omega-3 fatty acids) are among the suggestions for fetal macrosomia prevention.
Design of Multitarget Natural Products Analogs with Potential Anti-Alzheimer’s Activity
Authors: da Silva Hage-Melim Lorane Izabel , de Souza Franciane Nunes , de Lima Henrique Barros , de Souza Lucilene Rocha , Oliveira Gabrieli Santos , de Paula da Silva Carlos Henrique Tomich , Pereira Arlindo César Matias 
Published: March 2022

Background:
Alzheimer’s disease (AD) is a neurodegenerative condition and the most com-mon type of dementia among the elderly. The enzymes acetylcholinesterase (AChE) and nitric oxide synthase (NOS) have a pivotal role in the pathophysiology of this disease.

Objective:
This study aimed to select medicinal plant-derived molecules with reported inhibition of AChE and design optimized molecules that could inhibit not only AChE, but also NOS, potentially increasing its efficacy against AD.

Methods:
24 compounds were selected from the literature based on their known AChE inhibitory activity. Then, we performed molecular orbital calculations, maps of electrostatic potential, molecular docking study, identification of the pharmacophoric pattern, evaluation of pharmacokinetic and toxicological properties of these molecules. Next, ten analogs were generated for each molecule to optimize their effect where the best molecules of natural products had failed.

Results:
The most relevant correlation was between HOMO and GAP in the correlation matrix of the molecules’ descriptors. The pharmacophoric group’s derivation found the following pharmacophoric fea-tures: two hydrogen bond acceptors and one aromatic ring. The studied molecules interacted with the active site of AChE through hydrophobic and hydrogen bonds and with NOS through hydrogen interac-tions only but in a meaningful manner. In the pharmacokinetic and toxicological prediction, the com-pounds showed satisfactory results.

Conclusion:
The design of natural products analogs demonstrated good affinities with the pharmacolog-ical targets AChE and NOS, with satisfactory pharmacokinetics and toxicology profiles. Thus, the results could identify promising molecules for treating Alzheimer’s disease.
Comparison of energy parameters of electric storage systems for DC and AC traction power supply systems
Authors: Nezevak V. L. 
Published: March 2022

Introduction. The article discusses the energy parameters of electric power storage systems for DC and AC traction power supply systems. The purpose of the research is to evaluate the energy parameters of electric power storage systems located within the inter-substation zone boundaries of the AC traction power supply system at the 25 kV voltage.Materials and methods. The author used the methods of modeling, statistics and the experimental results processing. Moreover, the paper presented the parameter estimation of the energy accumulation system on the basis of the traction calculations for the AC rolling stock. In addition, the author made two variants of calculations — in the presence and the absence of the electric storage system. The researcher also made the simulation of the electric storage system for the voltage source connected to the sectioning post busbars.Results. Using the simulation modeling, the author presents active and reactive power graphs of the inter-substation zone boundaries in the active sectioning post operation conditions. Therefore, the article demonstrates the graph of the expected charge, the discharge depth calculations for the nominal energy capacity and the required charging features, which guarantee the charge restoration of the accumulation system to the initial level.Discussion and conclusion. The author offers the comparative assessment of the electric storage systems for the traction power supply with the DС voltage of 3 kV and the AC voltage of 25 kV. The research demonstrates the reducing potential of the nominal accumulation parameters.
Atrial fibrillation in old age: current treatment options
Authors: Kanorskii S. G. 
Published: March 2022

In older age, patients with atrial fibrillation (AF) have a high risk of stroke, bleeding, and death, but such patients have been underrepresented in randomized clinical trials. A search and analysis of 4 176 literature sources from the MEDLINE/ PubMed and eLIBRARY databases was carried out for the keywords «atrial fibrillation», «old age», «older», «elderly». The review includes the most important studies reflecting the current understanding of risk factors for development, complications and treatment of AF in old age. The results of therapy to control the ventricular rate, to control sinus rhythm in AF with drugs and catheter ablation are discussed. The data of studies on the prevention of thromboembolic complications in patients with AF by the use of anticoagulants and implantable devices are considered.
Telemedicine Acceptance Among Older Adult Patients With Cancer: Scoping Review
Authors: Pang Ning-Qi , Lau Jerrald , Fong Si-Ying , Wong Celine Yu-Hui , Tan Ker-Kan 
Published: March 2022

Background
Cancer is likely to remain the most prevalent noncommunicable disease in high-income countries with an older population. Interestingly, no review of attitudes toward telemedicine among older adults has been performed. This is likely to be the group most affected by both cancer and the increasing use of technology in health care.

Objective
We aimed to map research on the acceptance of telemedicine among older adults who are cancer patients.

Methods
We conducted a scoping review. PubMed, EMBASE, PsycINFO, CINAHL, and the Cochrane Central Register of Controlled Trials were systematically searched from inception to September 2020. Articles were included if the study population had a mean or median age ≥65 years, with cancer diagnoses and if the study assessed patients’ acceptance of a telemedicine intervention. Quantitative, qualitative, and mixed method studies were included.

Results
Out of a total of 887 articles that were identified, 19 were included in the review. Interventions were delivered via telephone, videoconference, web portal, mobile app, wearable technology, and text messaging and included teleconsultation, monitoring and follow-up, psychosocial support and nursing care, and prompts. The most often cited facilitating factor was convenience. Other facilitators included an increase in telemedicine care accessibility, previous positive experiences of telemedicine, appropriate technical knowledge and support, decreased cost, physician recommendations, and privacy conferred by the telemedicine intervention. Barriers include a preference for conventional care along with negative perceptions of telemedicine, concerns about technical difficulties, and confidentiality concerns in the adoption of telemedicine.

Conclusions
None of the studies explored the ability of tailored interventions to address facilitators and barriers of the acceptance of telemedicine in order to increase its adoption by older adults. Facilitators and barriers will likely differ across different cultural contexts and by type of telemedicine; however, this is a gap in current knowledge. In-depth studies are necessary to determine if interventions could potentially address the barriers identified in this review, to increase acceptability.
The Volume and Tone of Twitter Posts About Cannabis Use During Pregnancy: Protocol for a Scoping Review
Authors: Cresswell Liam , Espin-Noboa Lisette , Murphy Malia S Q , Ramlawi Serine , Walker Mark C , Karsai Márton , Corsi Daniel J 
Published: March 2022

Background
Cannabis use has increased in Canada since its legalization in 2018, including among pregnant women who may be motivated to use cannabis to reduce symptoms of nausea and vomiting. However, a growing body of research suggests that cannabis use during pregnancy may harm the developing fetus. As a result, patients increasingly seek medical advice from online sources, but these platforms may also spread anecdotal descriptions or misinformation. Given the possible disconnect between online messaging and evidence-based research about the effects of cannabis use during pregnancy, there is a potential for advice taken from social media to affect the health of mothers and their babies.

Objective
This study aims to quantify the volume and tone of English language posts related to cannabis use in pregnancy from January 2012 to December 2021.

Methods
Modeling published frameworks for scoping reviews, we will collect publicly available posts from Twitter that mention cannabis use during pregnancy and use the Twitter Application Programming Interface for Academic Research to extract data from tweets, including public metrics such as the number of likes, retweets, and quotes, as well as health effect mentions, sentiment, location, and users’ interests. These data will be used to quantify how cannabis use during pregnancy is discussed on Twitter and to build a qualitative profile of supportive and opposing posters.

Results
The CHEO Research Ethics Board reviewed our project and granted an exemption in May 2021. As of December 2021, we have gained approval to use the Twitter Application Programming Interface for Academic Research and have developed a preliminary search strategy that returns over 3 million unique tweets posted between 2012 and 2021.

Conclusions
Understanding how Twitter is being used to discuss cannabis use during pregnancy will help public health agencies and health care providers assess the messaging patients may be receiving and develop communication strategies to counter misinformation, especially in geographical regions where legalization is recent or imminent. Most importantly, we foresee that our findings will assist expecting families in making informed choices about where they choose to access advice about using cannabis during pregnancy.

Trial Registration
Open Science Framework 10.17605/OSF.IO/BW8DA; www.osf.io/6fb2e

International Registered Report Identifier (IRRID)
PRR1-10.2196/34421
Vulnerabilidades rurales a partir del envejecimiento entre nahuas del sur de Veracruz / Rural vulnerabilities due to aging among the Nahuas in southern Veracruz
Authors: Lazos-Chavero Elena , Jiménez-Moreno Marcela 
Published: March 2022

Las vulnerabilidades socioambientales, económicas y culturales del campo mexicano se expresan a través de las transformaciones generacionales y territoriales que minan los ámbitos agroambientales y alimentarios. El envejecimiento rural ha llevado a la venta de parcelas, migración juvenil, pérdida de agrobiodiversidad y transformaciones de los conocimientos agroecológicos que caracterizaban a los pueblos indígenas y campesinos. El objetivo de este artículo es analizar las consecuencias socioambientales y territoriales del envejecimiento rural en la sierra de Santa Marta, expresadas en la venta de sus tierras y pérdida de cultivos, lo que ha llevado al empobrecimiento de su seguridad alimentaria. En julio 2019, se levantaron 59 entrevistas en el ejido nahua de Tatahuicapan de Juárez con el fin de analizar las amenazas a la sustentabilidad y bienestar social en el sur de Veracruz.Abstract: The socio-environmental, economic and cultural vulnerabilities of rural Mexico are expressed through the generational and territorial transformations that undermine the agro-environmental foodscapes. Rural aging has led to the sale of family plots, youth migration, loss of agrobiodiversity and transformations of agro-ecological knowledge that characterized the peasantry and indigenous people. The aim of this paper is to analyze the socio-environmental and territorial consequences of rural aging in the Sierra de Santa Marta, expressed in the sale of land and the loss of crops, which has led to the impoverishment of their food security. In July 2019, 59 interviews were held in the ejido of Tatahuicapan de Juárez, of Nahua origin, in order to analyze the threats to sustainability and social well-being in the region.Keywords: rural aging; youth migration; agricultural succession; loss of agrobiodiversity; food security. Résumé : Les vulnérabilités socio-environnementales, économiques et culturelles du milieu rural se développent suite aux transformations générationnelles et territoriales qui ont affecté les espaces agroalimentaires et de l’alimentation. Le vieillissement des agriculteurs a entraîné de profonds changements dans la structure de la propriété, la migration de jeunes, la perte de l’agrodiversité et les transformatios des savoirs qui caracterient les peuples autochtones. Cet article vise à montrer comment le vieillissement des agriculteurs de la Sierra de Santa Marta a conduit à l’appauvrissement de leur sécurité alimentaire. Sur la base de 59 interviews réalisées en juillet 2019 dans l’ejido nahua de Tatahuicapan de Juárez afin d’analyser les menaces à la durabilité et au niveau du bien-être social.Mots-clés : vieillissement rural ; migration des jeunes ; héritage des terres ; perte d’agrodiversité ; sécurité alimentaire.
Nvidia Hopper GPU and Grace CPU Highlights
Authors: Elster Anne C. , Haugdahl Tor A. 
Published: March 2022

At GTC 2022 Nvidia announced a new product family that aims to cover
from small enterprise workloads through exascale HPC and
trillion-parameter AI models. This column highlights the most
interesting features of their new Hopper GPU and Grace CPU computer
chips and the Hopper product family. We also discuss some of the history
behind Nvidia technologies and their most useful features for
computational scientists such as the Hopper DPX dynamic programming
instruction set, increased number of SMs, and FP 8 tensor core
availability. Also included are descriptions of the new Hopper Clustered
SMs architecture and updated NVSwitch technologies that integrates their
new ARM-based Grace CPU.
"What’s left of human nature?", de Maria Kronfeldner
Authors: Jungk Isabel 
Published: March 2022

O livro se desenvolve a partir de uma perspectiva da filosofia da ciência com alcance para a filosofia social, moral e política. Distinguindo entre “natureza humana” (nH) – pensar o que significa ser humano a partir das propriedades que o tornam humano –, e “natureza humana” (Nh) – pensar o que significa ter uma natureza do ponto analítico e reflexivo –, Kronfeldner aborda o que significa argumentar que há um conceito de “natureza” aplicável filosoficamente aos humanos e quais suas implicações.
Buscar uma definição de Nh mostra-se central para pensar temas como evolução humana; divisões entre natureza e aprendizado/cultura; limites natureza/cultura (humano/animal; humano/máquina etc.), definição do que é inato e determinismo genético; universais humanos e variação cultural; diversidade genética e melhoramento (enhancement); inteligência artificial e transhumanismo, bem como moral, especismo, racismo, sexismo, normalidade, florescimento e essencialismo.
PLUS GreeN: Reconciling Urban Streams and Greenways through Placemaking
Authors: Sharma Archana 
Published: March 2022

Design and planning regarding urban streams are mostly viewed through the lens of ecological restoration the federal and state agencies. Cities and counties, undertaking the greenway and green network planning exercises mostly consider the urban streams as a sub-context, to be dealt with at a later stage or by different agencies. The middle ground between the urban streams, and urban greenways, thus often remains un-tended, and shows up as fragmented urban mosaic. Placemaking is often discussed in design and planning of architecture and landscape of urban built environment, to create a pause or interest or a place of rest for people. This paper considers placemaking as a landscape design approach to address the middle ground and reconcile the two ecologies of urban streams and greenways. A focused case research of an urban stream in northeast Baltimore is undertaken based on classic method of site-context analyses, federal, state, and local guides on stream restoration are considered and opportunities of bridging the connection are envisioned through conceptual design resolutions, underscored by the agenda of placemaking. As further research, the disconnect between various natural resources such as urban streams and urban greenways should be addressed through policies.
Consecinţele problematice ale aplicării încrederii şi recunoaşterii reciproce în contextul mandatului european de arestare
Authors: Sas Georgiana 
Published: March 2022

Încrederea şi recunoaşterea reciprocă sunt două principii care stau la baza implementării şi realizării spaţiului unic de libertate, securitate şi justiţie. Succesul rezonant al utilizării mandatului european de arestare se datorează premisei că, în aplicarea acestor principii, statele membre oferă standarde similare în materia cooperării judiciare datorită respectării unui set de valori comune. În ciuda acestui fapt, diferenţele culturale şi juridice dintre ţări, precum şi profundele transformări politice survenite în unele state au generat probleme practice care pun la îndoială actualitatea şi pragmatismul acestor deziderate.
Această lucrare tratează două deficienţe importante rezultate din aplicarea principiilor încrederii şi recunoaşterii reciproce – utilizarea mandatului european de arestare pentru infracţiuni de gravitate redusă şi imposibilitatea analizei cauzelor pe fond în cadrul acestei proceduri –, precum şi modul în care politica unor ţări precum Polonia şi Ungaria ameninţă coerenţa şi uniformitatea necesare pentru utilizarea operativă a mecanismelor de cooperare judiciară în materie penală. După o scurtă trecere în revistă a modului în care instituţiile unionale şi statele membre au încercat să remedieze aceste neajunsuri, partea secundă a lucrării încearcă identificarea unei soluţii durabile, pornind de la jurisprudenţa Curţii de Justiţie a Uniunii Europene.
Aspecte controversate privind aparenta încălcare a principiului ne bis in idem
Authors: Pelican George 
Published: March 2022

Fiind fundamentată pe o sistematizare a jurisprudenţei Curţii Europene a Drepturilor Omului şi a Curţii de Justiţie a Uniunii Europene, precum şi pe o analiză cuprinzătoare a lucrărilor de specialitate publicate la nivel naţional şi european, lucrarea de faţă a plecat de la premisa necesităţii asigurării unui just echilibru între interesul societăţii de a reprima în mod efectiv o conduită antisocială şi interesul individual de a nu fi tras la răspundere ori sancţionat în mod repetat pentru aceeaşi faptă antijuridică, demers ce poate părea extrem de dificil de pus în aplicare, în special prin prisma reconfigurării recente a principiului ne bis in idem.
Urmare a unei legislaţii supranaţionale cu deficienţe vădite, aspect ce a generat o practică extrem de fluctuantă a instanţelor europene, principiul ne bis in idem a avut parte, de-a lungul timpului, de o evoluţie remarcabilă, evoluţie aşteptată a se extinde din ce în ce mai mult în viitorul apropiat. Chiar dacă în prezent pare a se fi atins, în linii mari, dezideratul existenţei unor criterii de referinţă în scopul interpretării şi aplicării uniforme a acestei garanţii procesuale fundamentale, atât la nivel naţional, cât şi la nivel comunitar au fost generate o serie considerabilă de semne de întrebare relative la anumite ipoteze de încălcare aparentă a principiului ne bis in idem, care cu siguranţă vor mai subzista până la noi intervenţii lămuritoare ale forurilor europene.
Astfel, prezentul studiu a fost realizat cu scopul de a releva principalele aspecte controversate şi incertitudini existente la momentul actual în doctrină şi în practică în legătură cu sensul şi domeniul de aplicare a principiului ne bis in idem, propunându-şi, în acelaşi timp, să furnizeze clarificări necesare, precum şi să ofere eventuale soluţii adecvate prin raportare la legislaţia penală şi procesual penală de la nivel naţional.