bluuebunny/crossref_metadata_2025_split huggingface dataset:
OMFSurgery: Analyzing the use of social media applications in Oral and Maxillofacial Surgery resident training
Authors: Seifert Lukas Benedikt , Becker Philipp , Pabst Andreas , Sander Anna Katharina , Schneider Josephine , Schorn Lara , Zeller Alexander , Hoffmann Jürgen , Thiem Daniel 
Published: June 2022

Abstract
Background: Despite its increasing popularity, to our knowledge the use of social media applications (SM) for residents’ training in Oral and Maxillofacial Surgery (OMFS) has not been investigated yet. The aim of this study was to evaluate the use of SM applications by OMFS residents for post-graduate training in Germany.Methods: For explorative assessment, an online questionnaire containing 27 questions about the current use of SM for resident training was sent to OMFS residents in Germany.Results: Sixty-four colleagues participated to the study. Thirty-four participants (54%) responded to regularly use those platforms mainly for OMFS-related content. YouTube (65%, n = 37), Instagram (48%, n = 27), ResearchGate (25%, n = 14) and WhatsApp (16%, n = 9) were the most popular platforms. (Surgical) videos (97%, n = 59), pictures and graphics (82%, n = 50) were the mainly accessed contents. Forty-four participants (69%) stated that SM substantially contributed to their OMFS training. Dentoalveolar surgery and implantology (66%, n = 35) and aesthetic facial surgery (55%, n = 29) content contributed most to OMFS resident training. Fifty-one participants (80%) recommended an official SM account of the DGMKG.Conclusions: SM is frequently used by OMFS residents for the consumption of training-related content. There is an imbalance toward dentoalveolar and facial aesthetic surgery regarding the presented content. Academic institutions and societies should complement their educational activities to not miss this emerging educational innovation. Official SM content by academic institutions and societies could contribute to the existing educational activities.
The association between score of plant-based diet and non-alcoholic fatty liver disease in adults
Authors: Fallah Azadeh , abdolazimi Hamid , Darabi Zahra , Talenezhad Nasir , Mirzavandi Farhang , Rahimpour Shahab , Hosseinzadeh Mahdieh 
Published: June 2022

Abstract

Background: Plant-based diet as resource of antioxidants and anti-inflammatory phytochemicals, that was considered to protect against onset and development of NAFLD.Aim: To investigate the association between plant-based diet and NAFLD in adults.Methods: The present case control study was conducted on 240 individuals (120 with NAFLD and 120 control) aged 20–69 years. Provided recommendations by the American College of Gastroenterology and the American Gastroenterological Association were used for NAFLD diagnosis. Dietary intake was assessed using 178-food item food frequency questionnaire. Also, plant-based diet score was evaluated based on 18 food groups classified into animal foods, healthy and unhealthy plant foods. A multiple logistic regression model was used to examine the relationship between fatty liver disease and tertiles of PDI. Results: The results of this study showed that we did not observe any association between tertiles of plant-based diet index (PDI) and NAFLD in crude model (OR: 1.29, 95%CI:0.66 – 2.52, P:0.44) and after adjustment for confounders including age, energy intake, physical activity, body mass index (OR:0.76, 95%CI: 0.31 – 1.86, P:0.52). Also, there were not any association of tertiles of healthy PDI (hPDI) (OR:1.14, 95%CI: 0.50 – 2.60, P:0.74) and unhealthy PDI (uhPDI) (OR:0.89, 95%CI:0.36–2.18, P: 0.79) with NAFLD after full adjustment for potential confounders. Conclusion: There was not any association of PDI, hPDI, and uPDI with NAFLD in adults. More research needs to examine whether this specific diet may impact and improve NAFLD.
A cross-sectional analysis from the PAC-19QoLReg on the association between Quality of Life (QoL) of long COVID-19 patients and their disease duration
Authors: Jandhyala Ravi , Lin Yuhui 
Published: June 2022

Abstract
Background: The COVID-19 pandemic has been recognized for its long-term detrimental effects on the human population. The aim of this study was to report on the quality of life (QoL) from the interim analysis of COVID-19 positive patients registry data (PAC-19QoLReg) at baseline.Method: Self-declared patients who received COVID-19 positive diagnosis and/or had exhibited symptoms of lagged effects from post-COVID-19 for a duration of at least 28 days were recruited into the PAC-19QoLReg in December 2020 via social media, broadcasting platforms community forums and by word-of-mouth.Results: At primary recruitment, a total of 107 participants were recruited into the study. However, this interim data reports on N=74 long COVID-19 patients who have completed their baseline PAC-19QoL; Survey 1. The generalized linear model (GLM) Poisson regression was applied in this study to examine the association between exposure duration to COVID-19 and PAC-19QoL scores. The finalized model was adjusted for truncation time and age at recruitment. Truncation time was considered for its contribution in the delayed effects to complete the questionnaire upon recruitment, and such postponement varied among participants. The findings demonstrate that all participants were likely to recover in their QoL scores with increasing time since being diagnosed with COVID-19. The model underwent an elective statistical adjustment with the UK-only participants, and with truncation time at 0-14 and beyond 14 days. Participants who took >14 days to complete the survey were likely to recover in QoL scores than <=14 days. Conclusion: Findings from this study suggests a disproportional impact on patients by gender, age, and study country was observed, emphasizing that an awareness of patient-specific factors can assist clinicians in identifying those who may be at risk for diminished QoL as they progress. Furthermore, psychological adaptation to disease symptoms upon COVID-19 diagnosis was observed among the participants Trial registration: ClinicalTrials.gov Identifier NCT04586413 (14/10/2020)
Safety and efficacy of low-dose rt-PA with tirofiban to treat acute non-cardiogenic stroke: A single-center controlled study
Authors: Liang Zhigang , Zhang Junliang , Huang Shuangfeng , Yang Shaowan , Xu Luyao , Xiang Wei , Zhang Manman 
Published: June 2022

Abstract
Background and Purpose
The recanalization rate after intravenous thrombolysis (IVT) is not enough and there is still the possibility of re-occlusion. We aim to investigate the effectiveness and safety of infusing tirofiban after IVT.
Methods
We performed a prospective controlled study of 60 patients with acute non-cardiogenic ischemic stroke who were hospitalized in Yantai Yuhuangding Hospital from January 2018 to December 2019. The patients were divided into 2 groups: those who received tirofiban for 24 hours after IVT (rt-PA + T group) and those who did not receive postprocedural intravenous tirofiban (rt-PA group). The rt-PA + T group received low-dose rt-PA (0.6 mg/kg). The rt-PA group received standard dose rt-PA (0.9 mg/kg). The main outcome measure were safety, included the symptomatic intracranial hemorrhage (sICH), any ICH, severe systemic bleeding, and mortality. The secondary outcome measure is curative efficacy which were evaluated by the 7d-NIHSS score and functional outcomes at 90 days. During hospitalization, the deterioration of neurological function was recorded.
Results
All patients completed the follow-up with complete data, there were 30 patients in each of groups. The general characteristics between the two group patients had no statistically significant differences. Compared with the rt-PA + T group and the rt-PA group, in terms of safety, the rates of the sICH, severe systemic bleeding, and mortality in both groups were 0, and there was no statistically significant difference in the rates of any ICH between the two groups (10.0% vs 3.3%, P = 0.306). In terms of efficacy, the rate of the early neurological deterioration events (END) was no statistical significance (0 vs 6.6%, P = 0.246). There was no significant difference in the NHISS score between the two groups before the IVT, and also at 24h, however, the 7d-NIHSS score was lower in the rt-PA + T group compared with the rt-PA group (2.33 ± 1.85 vs 4.80 ± 4.02, P = 0.004). At 90 days, 83.3% of patients in the rt-PA + T group had favorable functional outcomes compared with 60.0% of patients in the rt-PA group (P = 0.045).
Conclusion
Low-dose rt-PA combined with tirofiban in acute non-cardiogenic ischemic stroke did not increase the risk of ICH, and mortality, and it was associated with neurological improvement.
Trial Registration:
The trial has been registered at the ChiCTR and identified as ChiCTR1800014666 (28/01/2018).
Comparative analysis and definition of types of reference resolution
Authors: kalman guljamal 
Published: June 2022

Abstract
This article describes new methods of solving reference resolution. The main method used here is, first of all, the method of solving by reference types, carrying out a theoretical study of methods for solving reference relations. Second, by a formal analysis of all types of references in Kazakh and Russian, English, a comparative study of all types of references in the three languages is conducted. For the Kazakh language, the absence of certain types and the definition of anaphoric and cataphoric relations in the language, taking into account the linguistic features. The purpose of solving reference resolution in this method is to highlight previously undeveloped and fully solved methods, and to search the literature for methods of solving reference types and convenient ways of solving reference resolution using methods of theoretical investigation, formal analysis, and verification of developed research papers in the field. A comparison of the eight methods of solving reference resolution among themselves in this study with the new method of solution is shown in Table 7. And by relating the nine reference types to the eight methods that conducted this theoretical research work, we can see that the complete solution of the reference types can only be solved in our method. The article studies the function of pronouns in the word and taking into account the linguistic features of Kazakh Russian and English, from which we can extract specific types of reference types by eliminating interlingual differences.
Application of intracardiac echocardiography in the radiofrequency ablation of atrial fibrillation
Authors: xue feng , Sun Yunjuan , lin ling , Zhang Fangfang , Zhu Shasha , Guo Xiao , Wang Shuhuan , Liu Ming , Hui Jie , Jiang tingbo 
Published: June 2022

Abstract
Background Intracardiac echocardiography (ICE) has been used in the radiofrequency ablation of arrhythmia since 1994. This study investigated the efficacy and safety of ICE assiting the ablation of atrial fibrillation.Methods From May 2020 to February 2021, 100 patients with atrial fibrillation underwent radiofrequency ablation assisted by ICE and three-dimensional mapping system. They were enrolled in ICE group. In the same period, 100 patients with atrial fibrillation who only received radiofrequency ablation assisted by three-dimensional mapping system were enrolled in control group. The patients were followed up and the fluoroscopy times, complications and success rates were compared. Results 1. The X-ray fluoroscopy times in ICE group was significantly shorter than that in control group. In ICE group there was no pericardial tamponade during atrial septal puncture. But in control group there were three cases of pericardial tamponade during atrial septal puncture; 2. The injury of vagus nerve around esophagus in ICE group was significantly less than that in control group; 3. There was no significant difference in the success rate between the two groups. Conclusions ICE can significantly increase the safety of the radiofrequency ablation of atrial fibrillation.
Improved complete portal 4-port robotic lobectomy for lung cancer: ‘Hamamatsu Method KAI’
Authors: Funai Kazuhito , Kawase Akikazu , Takanashi Yusuke , Mizuno Kiyomichi , Shiiya Norihiko 
Published: June 2022

Abstract
Background: Robotic-assisted thoracic surgery has been widely used in the treatment of lung cancer. We devised a new port arrangement at robot-assisted thoracoscopic surgery for lung cancer, the “Hamamatsu method” to provide a good cranial field of view using the da Vinci Xi surgical system, last year. It consists of four robot ports and one assist port, while our video-assisted thoracoscopic lobectomy is performed with four ports.Methods: By combining the access port and camera port of “Hamamatsu Method”, we devised the 4-port “Hamamatsu Method KAI” equivalent to the conventional 5-port method without changing the operability. Then, in order to prove the safety of “Hamamatsu Method KAI,” the bleeding volume, drain placement period, operation time, and console time were compared with the conventional 5-port case.Results: In 18 cases of lung cancer who underwent anatomical lung resection by “Hamamatsu Method KAI,” there was no significant difference in bleeding volume, drain placement period, operation time, and console time compared with the conventional 5-port case. No thoracotomy conversion case was detected.Conclusions: Robotic surgery should not ideally increase the number of wounds than thoracoscopic surgery to preserve the minimal invasiveness advantage. Furthermore, patients are generally more sensitive to wound size and number than what surgeons assume. Therefore, we devised a method to reduce the number of ports without degrading the robotic surgery quality. The improved 4-port “Hamamatsu Method KAI” method combines the access port with the camera port and helps ensure minimal invasiveness while maintaining the same feasibility as the original method.
Herb-Symptom analysis of Erchen Decoction combined Xiebai Powder prescription and its mechanism of action in treating chronic obstructive pulmonary disease
Authors: Ye Hua , He Beibei , Yu Ziwei , Feng Yifan , Wen Chuanbiao , Feng Quansheng 
Published: June 2022

Abstract
Background
In this study, Herb-Symptom analysis of Erchen Decoction combined Xiebai Powder (ECXB) prescription was conducted based on the SymMap platform, and the synergistic mechanism of this prescription in the treatment of chronic obstructive pulmonary disease (COPD) was explored by network pharmacology and molecular docking method.
Methods
The SymMap platform was used to collect information related to Traditional Chinese Medicine (TCM) symptoms and Modern Medicine (MM) symptoms prescribed by ECXB, and the “Herb-TCM Symptoms” network and “Herb-MM symptoms” network were drawn for Herb-Symptom analysis. TCMSP database was used to screen the active ingredients and corresponding targets of ECXB. GeneCards database was used to screen Chronic obstructive pulmonary disease related targets, which were mapped to the predicted targets of ECXB to obtain the action targets of ECXB in the treatment of Chronic obstructive pulmonary disease. Cytoscape software was used to construct the “Drug-ingredient-target” network. Protein-protein Interaction (PPI) network was analyzed by STRING database, and the core targets were obtained. DAVID database was used for Gene Ontology (GO) analysis and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway enrichment analysis.
Results
Herb-Symptom analysis showed that ECXB prescription drugs had similar symptoms with COPD patients. Network pharmacology obtained 170 active ingredients with 137 corresponding targets, and 7002 Chronic obstructive pulmonary disease action targets were obtained. 120 ECXB treating chronic obstructive pulmonary disease joint action targets were obtained by intersection mapping, among which the core targets include MAPK8, ESR1, TP53, MAPK3, JUN, RELA, MAPK1, and AKT1. The GO enrichment analysis results indicated that ECXB mainly participates in response to drug, response to nutrient levels, response to extracellular stimulus, response to oxygen levels, and other biological processes. The pathway analysis showed that ECXB treating Chronic obstructive pulmonary disease by regulating hepatitis B, pathways in cancer, TNF signaling pathway, and so on.
Conclusions
This study analyzed the medication rule of ECXB prescription in the treatment of COPD from a new perspective, and found that the symptoms of TCM treatment with ECXB prescription were similar to those of Modern medicine treatment, and that ECXB could treat COPD through multi-component, multi-target, and multi-pathway synergistic effects, providing a scientific basis for further study on the mechanism of ECXB treatment of chronic obstructive pulmonary disease. It also provides new ideas for drug development.
UGP2, a novel target gene of TP53, inhibits endothelial cells apoptosis and atherosclerosis
Authors: He Xin , Chen Juan-Jiang , Hu Xiu-Mei , Wu Chang-Meng , Zhang Ru-Yi , Yang Biao , Zheng Lei , Wang Qian 
Published: June 2022

Abstract

Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an important contributor to the pathobiology of atherosclerotic cardiovascular disease. Recent studies have indicated that UDP-glucose pyrophosphorylase 2(UGP2) is implicated in cell proliferation and survival. Here we investigated the anti-apoptosis and anti-atherogenic effect of UGP2 in vitro and in vivo.Here, we explored the effects and mechanisms of UGP2 on apoptosis in endothelial cells by flow cytometer and Western blot analyses. And we engineered ldlr−/−ugp2+/− double-deficient mice to evaluated the apoptosis levels in atherosclerotic lesion. A microarray analysis showed that the expression of UGP2 was reduced in human atherosclerotic plaques. In vitro experiments revealed that TP53 interacted with the promotor region of the UGP2 gene, which upregulated UGP2 expression. Augmentation of UGP2 expression downregulated ROS levels, the expressions of Cleaved caspase-3 and apoptosis levels in endothelial cells, and this inhibitory effects of UGP2 on cell apoptosis could be significantly abolished by H2O2. In vivo experiments using ldlr−/−ugp2+/− mice fed a Western high-fat diet demonstrated that UGP2 deficiency promoted atherosclerosis, and increased the levels of ROS, expressions of Cleaved caspase-3 and apoptosis cells in atherosclerotic lesions. Thus, our results provide evidence for UGP2 as a novel target gene of TP53 contributes to anti-apoptosis effect linking to ROS homeostasis differ from canonical pathway, and we suggested that UGP2 could act as potential therapeutic targets to ameliorate atherosclerosis-related diseases.
Clinical characteristics and risk factors of hepatitis B virus-related cirrhosis in Chinese adults aged 40 years or younger: a retrospective study
Authors: Li Jing , Wen Jun , Feng Yongmei , Wang Chunyan , Jia Li , Zhu Yujin 
Published: June 2022

Abstract
Background: In China,the incidence of cirrhosis in young patients is not low, and some patients initially present with serious life-threatening decompensated liver cirrhosis. So we retrospectively analyze the clinical characteristics and risk factors of young (age ≤ 40 years) patients with hepatitis B virus-related cirrhosis. Methods: 163 patients with hepatitis B virus-related cirrhosis admitted to Tianjin Second People's Hospital from June 2019 to August 2020 were enrolled, and they were divided into age ≤ 40 years old group (n = 102) and age > 40 years old group (n=61). All patients were initially diagnosed as hepatitis B virus-related cirrhosis and did not receive antiviral therapy. All patients performed liver function, HBV serum markers, HBV DNA, abdominal ultrasonography,elastography,abdominal CT, and gastroscopy detections at the same period. The differences in clinical indicators between the two groups were compared, and the independent risk factors for hepatitis B cirrhosis of age ≤40 years old were further explored. Results: Compared with patients aged > 40 years, the proportion of male with hepatitis B cirrhosis in the age ≤ 40 years group was higher (P<0.05), the proportion of patients with family history of liver disease was lower (P<0.05), the levels of ALT, GGT, ALB, CHE are higher (P<0.05), the level of TBIL is lower (P<0.05), the level of HBV DNA is higher (P<0.05); and the proportion of patients with compensatory cirrhosis is higher (P<0.001). Multivariate logistic regression analysis showed that elevated GGT levels(P=0.010,OR=1.007,95%CI:1.002-1.013), and higher HBV DNA levels(P=0.025,OR=1.353,95%CI: 1.039-1.760)are independent risk factors for hepatitis B virus-related cirrhosis in patients aged ≤40 years. Conclusions: Hepatitis B virus-related cirrhosis in Chinese adults aged ≤40 years have more obvious liver inflammation, better liver synthesis, and reserve function, more active replication of hepatitis B virus, and a higher proportion of patients at the compensatory stage of cirrhosis. Elevated GGT and HBV DNA level are risk factors of cirrohosis. For these patients, reinforced follow-ups are required,and liver biopsy should be actively performed, use of antiviral drugs may be considered if necessary.
Research on imbalance machine learning methods for MRT1WI soft tissue sarcoma data
Authors: Liu Xuanxuan , Guo Li , Wang Hexiang , Guo Jia , Yang Shifeng , Duan Lisha 
Published: June 2022

Abstract
Background: Soft tissue sarcoma is a rare and highly heterogeneous tumor in clinical practice. Pathological grading of the soft tissue sarcoma is a key factor in patient prognosis and treatment planning while the clinical data of soft tissue sarcoma are imbalanced. In this paper, we propose an effective solution to find the optimal imbalance machine learning model for predicting the classification of soft tissue sarcomas data. Methods: In this paper, a large number of features are first obtained based on T1WI images using the radiomics methods. Then, we explore the combinations of different sampling techniques, feature selection methods, and classification algorithms, and get nine imbalance machine learning models based on the above features. The receiver operating characteristic curve model is used to evaluate the performance of these nine methods on predicting the pathological grade of soft tissue sarcoma. Results: The experimental results show that the combination of extremely randomized trees classification algorithm using random oversampling examples (ROSE) and the recursive feature elimination technique performs best compared to other combination methods. The receiver operating characteristic area under the curve, accuracy, sensitivity, specificity and G-mean of this method for predicting high-grade versus low-grade soft tissue sarcoma are 0.9457, 94.61%, 93.55%, 95.59% and 0.9456, respectively. Conclusion: Preoperative predicting pathological grade of soft tissue sarcomas in an accurate and noninvasive manner is essential. Our proposed machine learning method can make a positive contribution to solving the imbalanced data classification problem, which can favorably support the development of personalized treatment plans for soft tissue sarcoma patients.