bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal intra-individual variation of sex pheromone released by female Chilo suppressalis and its application
Authors: Guo Qianshuang , Liu Zhendong , Chen Xiaolan , Wu Xiangwen , Chen Liling , Du Yongjun 
Published: July 2022

Abstract
Individual variation in sex pheromones occurs in insects, but evidence for temporal intra-individual variation in single individuals is lacking. We used individual adult female Chilo suppressalis (Lepidoptera: Crambidae) of different ages and analyzed the titer changes in sex pheromone emitted at different times of scotophase. The data showed the temporal dynamics of sex pheromones emitted by individual moths. The results revealed individual variation of sex pheromone release time related to age, diel variation, length of time, titer, and the ratio of pheromone compounds. Two-day-old females released the highest pheromone rates and showed the greatest variability in the ratios of major compounds. The correlation between the percentage of Z11-16:Ald in the mixture and the titer of Z11-16:Ald was significantly positive. After the sex pheromone was secreted from the gland, temperature affected the rate of its release. As the temperature increased, the release rate increased. Sex pheromone release decreased rapidly after mating, but the Z11-16:OH levels in some females were similar before and after mating. Variations in these ratios and titers were reflected in differences in the attractiveness of synthetic blends in field trapping. In addition, the optimal ratio of sex pheromones varies with the total dose of the mixture. This results from this study will be helpful for designing effective formulations of synthetic sex pheromones. These data also increase our understanding of the olfactory recognition, calling, and mating behavior of C. suppressalis.
Pan-cancer whole genome comparison of primary and metastatic solid tumors
Authors: Cuppen Edwin , Martinez-Jimenez Francisco , Movasati Ali , Brunner Sascha , Nguyen Luan , Priestley Peter , Hoeck Arne van 
Published: July 2022

Abstract
Metastatic cancer remains almost inevitably a lethal disease. A better understanding of disease progression and response to therapies therefore remains of utmost importance. Here, we characterize the genomic differences between early-stage untreated primary tumors and late-stage treated metastatic tumors using a harmonized pan-cancer (re-)analysis of 7,152 whole-genome-sequenced tumors. In general, our analysis shows that metastatic tumors have a low intra-tumor heterogeneity, high genomic instability and increased frequency of structural variants with comparatively a modest increase in the
number of small genetic variants. However, these differences are cancer type specific and are heavily impacted by the exposure to cancer therapies. Five cancer types, namely breast, prostate, thyroid, kidney clear carcinoma and pancreatic neuroendocrine, are a clear exception to the rule, displaying an extensive
transformation of their genomic landscape in advanced stages. These changes were supported by increased genomic instability and involved substantial differences in tumor mutation burden, clock-based molecular signatures and the landscape of driver alterations as well as a pervasive increase in structural variant burden. The majority of cancer types had either moderate genomic differences (e.g., cervical and colorectal cancers) or highly consistent genomic portraits (e.g., ovarian cancer and skin melanoma) when comparing early- and late-stage disease. Exposure to treatment further scars the tumor genome and introduces an evolutionary bottleneck that selects for known therapy-resistant drivers in approximately half of treated patients. Our data showcases the potential of whole-genome analysis to understand tumor evolution and provides a valuable resource to further investigate the biological basis of cancer and
resistance to cancer therapies.
Sickle cell disease-related knowledge and perceptions of traditional healers in tribal communities in India: implications on sickle cell disease programme
Authors: Babu Bontha V. , Srid Parikipandla , Surti Shaily B. , Bhat Deepa , Sarmah Jatin , Sudhakar Godi , Sharma Yogita 
Published: July 2022

Abstract
Sickle cell disease (SCD) is a progressively debilitating genetic disease, and India is the second most affected nation in SCD births. SCD births are high among Indian indigenous tribal communities, whose health care is pluralistic. Traditional healers are an essential part of tribal pluralistic care. This study aimed to understand the extent of SCD-related knowledge and practices of traditional healers and their willingness to be part of the programme. Following the grounded theory approach, data were collected by in-depth interviews with 40 traditional healers selected from five SCD endemic districts. Text data were coded through a deductive approach, and thematic content analysis was carried out. A few healers knew the SCD. However, almost all are aware of anaemia and its symptoms. Most were unaware of the cause of SCD and mentioned that malnutrition and anaemia are reasons for the recurrence of SCD-related symptoms. Most of the traditional healers did not give any treatment. Some gave symptomatic treatment and provided herbal medicines along with some rituals. Though some healers treated some of the typical symptoms of SCD like spleen enlargement, jaundice, swelling and pains in joints, they could not link them with SCD. All traditional healers expressed the concern and said they support the government-run SCD programme. The programme should recognise the role and importance of traditional healers. Necessary orientation may be given to the healers. Such involvement and orientation empower the traditional healers in appropriately guiding the people concerning SCD care.
Comparison Between Buccal Fat Pad Flap and Buccal Advancement Flap for Closure of Oroantral Fistula: A Systematic Review
Authors: Quinzi Vincenzo , Gallusi Gianni , Cannatelli Matteo , Marchetti Enrico , Fiasca Fabiana , Mummolo Stefano 
Published: July 2022

Abstract
Purpose: The aim of the present study was to evaluate the success rate of two different surgical techniques used to close oroantral fistula.Material and Methods: A systematic Review was conducted based on the PRISMA guideline. Selected reports from electronic databases (PubMed, LILACS, Semantic Scholar, Cochrane Library, Rutgers University Library and Europe PMC) for studies conducted from 1959 to 2021 were initially evaluated. The inclusion criteria were recent English-language studies, all human studies and studies comparing buccal fat pad (BFP) and buccal advancement flap (BAF).The research individuated 1455 records. After screening, only 4 studies were assessed; 1 retrospective study and 3 comparative studies.Results: The pooled RR was significant, showing a probability of success of Buccal Advancement Flap slightly lower than the Buccal Fat Pad Flap for closure of an oroantral fistula (RR 0.914, 95% CI: 0.836 - 0.998). Heterogeneity between the included studies was absent (I2 0.0%, P=0.452).Conclusion: Both techniques are safe, simple and with a high success rate. BFP is ideal in the closure of oroantral fistulas of more than 5 mm, when it is necessary to preserve the depth of the vestibular sulcus or when the buccal advancement flap fails.
Risk of second primary malignancy after radioiodine for thyroid carcinoma: a SEER-based study
Authors: Wu Weiming , Li Shujie , Zhang Ruyi , Wang Miao , Jia Qiang , Tan Jian , Li Ning , Wang Shen , Ji Yanhui , Xu Ke , Meng Zhaowei 
Published: July 2022

Abstract
Purpose
The objective of this study is to evaluate the benefits of radioactive iodine (RAI) treatment and the risk of second primary malignant (SPM) in RAI treated patients.
Methods
The cohort for this analysis consisted of individuals diagnosed with a first primary differentiated thyroid carcinoma (DTC), reported by SEER database in 1988–2016. Overall survival (OS) difference was estimated by Kaplan–Meier curves and Log-Rank test, and hazard ratios (HR) was obtained by cox proportional hazard model to evaluate the association between RAI and SPM. Standardized incidence ratios (SIR) were calculated to assess cancer incidence in relation to RAI and no-RAI groups and the general population.
Results
Among 130,902 patients, 61,210 received RAI and 69,692 did not and a total of 8,604 patients developed SPM. We found that OS was significantly higher in patients who received RAI than those who did not (P < 0.001). DTC survivors treated with RAI had increased risk of SPM in females (6.27% versus 5.97%, P = 0.043), particularly for SPM occurred in ovary (RAI group: 0.17%, no-RAI group: 0.12%, P = 0.039) and leukemia (RAI group: 0.22%, no-RAI group: 0.12%, P < 0.0001). In addition, RAI group in all age subgroups demonstrated higher SPM incidence than no-RAI group, and the incidence increased with age. Patients with primary thyroid cancer had a 16% elevated risk of developing SPM in all sites (SIR:1.16), 243% elevated risk in salivary glands (SIR:3.43), 119% elevated risk in kidneys (SIR:2.19), and 46% elevated risk in hematopoietic System (SIR:1.46). In general, the risk of developing SPM was higher in RAI group than in no-RAI group and general population.
Conclusions
Increased risks of SPM occur in female DTC survivors treated with RAI, which become more obvious with age increasing. Our research findings were beneficial to the formulation of radioactive iodine treatment strategies and the prevention of secondary tumors for patients with thyroid cancer of different genders and different ages.
Makespan Optimization of Workflow Application based on Bandwidth Allocation Algorithm in Fog-Cloud Environment
Authors: Dougani Bentabet , Dennai Abdeslem 
Published: July 2022

Abstract
Fog computing technology has emerged to handle the large amount of data generated by Internet of Things (IoT) terminals and cope with latency-sensitive application requests by allocating computation and storage resources at the edge of the Internet. In many IoT applications, the data acquisition procedures must apply the Directed Acyclic Graph (DAG) to get real-time results. The principal goal of DAG scheduling is to reduce total completion time without breaking priority constraints by properly allocating tasks to processors and arranging task execution sequencing. In this paper, we propose a bandwidth-aware workflow allocation (BW-AWA) that schedules tasks by priority to the resource that minimizes the total execution time (Makespan) in the entire heterogeneous computing system without affecting the increase in energy consumed. The task selection process needs to consider the dependency between tasks. The proposed approach is tested with a road safety case study, and the results are compared to well-known approaches to demonstrate the effectiveness in reducing the Makespan.
Improved adherence to test, treat, and track (T3) malaria strategy among Over-the- Counter Medicine Sellers (OTCMS) through interventions implemented in selected rural communities of Fanteakwa North district, Ghana
Authors: Soniran Olajoju Temidayo , Mensah Benedicta Ayiedu , Cheng Ndong Ignatius , Abuaku Benjamin , Ahorlu Collins Stephen 
Published: July 2022

Abstract
Background: Prompt diagnosis and treatment of malaria prevents a mild case from developing into severe disease and death. Unfortunately, parasitological testing of febrile children is greater in the public and formal private sector than in the informal private sector where many patients with malaria-like symptoms first seek treatment. This study was aimed at improving implementation of the T3 policy among OTCMS using some interventions that could be scaled-up easily at the national level.Methods: Interventions were evaluated using a two-arm, cluster randomized trial across 8 rural communities (4 clusters per arm), in two adjacent districts of Ghana. A total of 7 OTCMS in the intervention arm and 5 OTCMS in the control arm in the selected communities participated in the study. Five (5) interventions were implemented in the intervention arm only. These were acquisition of subsidized malaria rapid diagnostic test (mRDT) kits, training of OTCMS, supportive visits to OTCMS, community sensitization on malaria, and introduction of malaria surveillance tool. The primary outcome was the proportion of children under 10 years with fever or suspected to have malaria visiting OTCMS and getting tested (using mRDT) before treatment. Secondary outcomes included OTCMS adherence to national malaria treatment guidelines and the recommended mRDT retail price. Outcomes were measured using mystery client (an adult who pretends to be a real patient) surveys supplemented by a household survey. Proportions were compared using chi-square test or fisher exact test.Results: Following deployment of interventions, mystery client survey showed that OTCMS’ adherence to malaria protocol in the intervention arm increased significantly (p<0.05) compared to the control arm. Household surveys in the intervention arm showed that Caregivers self-treating their children or visiting drug vendors significantly decreased in favor of visits to OTCMS shops for treatment (p<0.001). End-line malaria testing rate was higher compared with the baseline rate, though not statistically significant (30.8% vs 10.5%; p=0.1238). OTCMS in the intervention arm also adhered to the subsidized mRDT retail price of GHc2.40.Conclusion: Interventions targeting OTCMS in rural communities have the potential of improving adherence to the T3 malaria policy and subsequently improving management of uncomplicated malaria in Ghana.Trial registration: ISRCTN registry ISRCTN77836926. Registered on 4 November 2019.
Caesarean section and childhood obesity at age 3 years: a large-scale birth cohort study— the Japan Environment and Children’s Study
Authors: Terashita Shintaro , Yoshida Taketoshi , Matsumura Kenta , Hatakeyama Takehiro , Inadera Hidekuni 
Published: July 2022

Abstract
Background
Caesarean section (CS) birth is widely reported to be a risk factor for childhood obesity, but it is unclear whether this association also applies in the Japanese population.
Objectives
To assess the impact of CS birth on obesity at 3 years of age in Japanese children.
Methods
We obtained data from the Japan Environment and Children’s Study, a large-scale birth cohort study that includes 103,057 pregnancies, on delivery mode and covariates. Obesity was determined by body mass index measured at 3 years of age. Adjusted odds ratios were estimated using multivariable logistic regression.
Results
From 60,417 mother–toddler pairs analysed, 11,125 toddlers (18.4%) had a CS birth and 12,713 toddlers (21.0%) were obese. The adjusted odds ratio for obesity at 3 years of age when born by CS compared with vaginal delivery was 1.13 (95% confidence interval [CI] 1.07–1.19). This increased odds ratio was significant for girls (1.20, 95% CI 1.11–1.30) but not boys (1.07, 95% CI 0.996–1.15).
Conclusions
CS birth modestly increases the risk of obesity at 3 years of age in Japanese children, especially girls.
Characterization of co-existing adenoma and adenocarcinoma in comparison with conventional adenocarcinoma of gallbladder
Authors: Zou Rui-Qi , Hu Hai-Jie , Lv Tian-Run , Wang Jun-Ke , Liu Fei , Dai Yu-Shi , Hu Ya-Fei , Ma Wen-Jie , Li Fu-Yu 
Published: July 2022

Abstract
Background
Gallbladder adenoma-adenocarcinoma is a rare pathway of gallbladder malignancy, while little is known about the clinicopathological characteristics and surgical outcomes about co-existing adenoma and adenocarcinoma of gallbladder (CAAG).
Methods
Between January 2010 and December 2020, 73 CAAG patients who underwent curative surgical resection at West China Hospital of Sichuan University were retrospectively reviewed.
Results
The clinicopathological characteristics of CAAG were distinct from conventional gallbladder adenocarcinoma (GBAC). Patients with CAAG were less likely to have liver parenchyma invasion (P = 0.010), and more commonly to have smaller tumor sizes (P = 0.040), early T stage (P < 0.001) and lower CA19-9 level (P < 0.001). Compared with conventional GBAC patients, CAAG patients showed significantly better overall survival (OS) (36.0 vs 25.0 months; P = 0.001). Multivariate analysis confirmed tumor size (P = 0.047), T stage (P = 0.007), surgical margin (P < 0.001) and histological subtypes (P = 0.037) as independent prognostic factors influencing OS of patients with CAAG. Furthermore, compared with none-papillary CAAG, papillary CAAG patients showed even worse survival outcome (30.0 vs 40.0 months, P = 0.005).
Conclusion
CAAG always has mild biological behaviors and better survival outcomes after curative surgery. Larger tumor size, advanced T stage and positive surgical margin were associated with inferior OS in patients with CAAG. The histological subtype of papillary CAAG patients showed the worse survival outcome.
High-efficiency microwave-optical quantum transduction based on a cavity electro-optic superconducting system with long coherence time
Authors: Zorzetti Silvia , Wang Changqing , Gonin Ivan , Grassellino Anna , Kazakov Sergey , Romanenko Alexander , Yakovlev Vyacheslav 
Published: July 2022

Abstract
Frequency conversion between microwave and optical photons is a key enabling technology to create links between superconducting quantum processors and to realize distributed quantum networks. We propose a microwave-optical transduction platform based on long-coherence time superconducting radio-frequency (SRF) cavities coupled to electro-optic optical cavities to mitigate the loss mechanisms that limit the attainment of high conversion efficiency. In the design, we optimize the microwave-optical field overlap and optical coupling losses, while achieving long microwave and optical photon lifetime at milli-Kelvin temperatures. This represents a significant enhancement of the transduction efficiency up to 50% under pump power of 140 μW, corresponding to few-photon quantum regime. Furthermore, this scheme exhibits high resolution for optically reading out the dispersive shift induced by a superconducting transmon qubit coupled to the SRF cavity. We also show that the fidelity of heralded entanglement generation between two remote quantum systems is enhanced by the low microwave losses. Finally, high-precision in quantum sensing can be reached below the standard quantum limit.
Application of UPLC-Orbitrap-HRMS targeted metabolomics in screening of allelochemicals and model plants of ginseng
Authors: Meng Xiang-Ru , Huang Xin , Li Qiong , Wang En-Peng , Chen Chang-Bao 
Published: July 2022

Abstract
Purpose
Allelopathy coordinated with multi-factors leading to continuous cropping obstacle, caused serious decline in yield and quality of ginseng. The cultivation of ginseng is affected by self-toxicity of allelochemicals in soil. Due to the long growth cycle and low survival rate of ginseng, rapid allelopathic activity screening is difficult. Therefore, it is very important to systematically analyze allelochemicals and find model plants with similar allelopathic respondence of ginseng.
Methods
Based on UPLC-Orbitrap-HRMS targeted metabolomics and allelopathic activity verification, soil with continuous cropping problem was determined. Allelochemicals markers were screened by OPLS-DA. The seeds and seedlings of maize, Chinese cabbage, cucumber, green beans, wheat, sunflower and oats were selected as receptors. The model plants with similar allelopathic respondence as ginseng were evaluated by comparison of morphological, physiological and biochemical characteristics.
Results
The allelopathic activity of n-butanol extract of soil with continuous cropping problem was most significant. 23 ginsenosides and their contributions to allelopathic effect were screened out and evaluated. The allelopathic effects of ginsenosides Rd, Rg2, Rb1, Rb2, Rb3, Rg1, Re, and Ro, were consistent with the previous results of our group and literature. Under the action of allelochemicals, seeds and seedlings of cucumber showed similar growth inhibition tendency with ginseng.
Conclusion
Metabolomics could be applied to screen allelochemicals in soil and predict their allelopathic effects. And the established plant model could be used to rapid screen allelopathic activity of ginseng. This study provided methodology reference for allelopathy research of ginseng.
Facilitators and barriers to an organisation-based communication skills training program: an interview study
Authors: Wolderslund Maiken , Waidtløw Karin , Kofoed Poul-Erik , Ammentorp Jette 
Published: July 2022

Abstract
Background: This study aimed to investigate the facilitators and barriers experienced by department managements (DMs) and communication skills trainers (trainers) during the implementation of a 3-day communication skills training (CST) programme for healthcare professionals (HCPs).Methods: Semi-structured interviews were conducted with 23 DMs and 10 trainers from 11 departments concurrently with the implementation of the CST programme. The interviews were conducted from 2012 to 2015 and focused on barriers and facilitators as experienced by DMs and trainers. Thematic analysis was conducted to elucidate the themes across the interviews.Results: The following five themes were developed: resource consumption, bumps in the road, management support, efforts and outcomes, and lack of systematic follow-up. Although the DMs and trainers were, by large, in agreement, the theme: lack of systematic follow-up, derived exclusively from the interviews with the trainers, as did two of the subthemes within bumps in the road: seniority, profession and cultural differences and the trainers' competencies.Conclusion: The greatest perceived barrier was the number of resources needed to be allocated to the CST courses. In addition, DMs found planning and staff resistance to be a challenge. However, after having participated, the HCPs' resistance diminished or even changed to satisfaction. The mandatory approach served as both a facilitator, and a barrier, DMs’ support was an essential facilitator. To ensure sustainability over time, systematic follow-up and continuous training of trainers are needed. Furthermore, explicit communication related to the resource demands, expectations in terms of planning and participation are essential whereas management support and allocation of resources are crucial.