bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non-coding RNA SPRY4-IT1 promotes proliferation and metastasis in nasopharyngeal carcinoma cell
Authors: Li Yanfei , Liao Zhenpeng , Wang Rong , Liang Zibin , Lin Zhihe , Deng Shiqi , Chen Lei , Liu Zhigang , Feng Shaoyan 
Published: March 2022

Background
Long non-coding RNA SPRY4 intronic transcript 1 (Lnc RNA SPRY4-IT1) was aberrant-expressed in various kinds of cancer. Increasing evidence demonstrated that lnc RNAs involved in tumorigenesis and metastasis. In this study, we aimed to explore the biological role of SPRY4-IT1 on the phenotype of nasopharyngeal carcinoma (NPC) in vitro and in vivo.

Methods
The expression level of SPRY4-IT1 in NPC cell lines were measured by quantitative real-time polymerase chain reaction (qRT-PCR). Cell Counting Kit-8 (CCK-8) and colony formation assay were used to detect cell proliferation. Wound-healing assay, transwell assay and animal experiment were performed to evaluate the ability of cell migration and metastasis. Cell cycle distribution and apoptosis were determined by flow cytometry. Western blotting and immunofluorescence were employed to identify protein expression.

Results
SPRY4-IT1 was significantly up-regulated in several NPC cell lines (6-10B, CNE-2, and HONE-1) compared with human immortalized nasopharyngeal epithelial cell (NP69). Silencing of SPRY4-IT1 inhibited proliferation, migration, and metastasis, and induced significant G2/M phase arrest and apoptosis. Western blotting showed that the expression levels of cell cycle-related proteins (cyclin B1, cdc2 and p-cdc2) were down-regulated and apoptosis-associated proteins (PARP, cleaved PARP and cleaved caspase-3) were up-regulated after knockdown of SPRY4-IT1. The expression level of E-cadherin was increased and the expression of Vimentin, Snail and Twist1 were decreased after the SPRY4-IT1 knockdown.

Conclusion
lncRNA SPRY4-IT1 played a significant role in NPC proliferation, migration and metastasis, suggesting that SPRY4-IT1 might be a potential therapeutic target for the treatment of NPC.
The PTEN hamartoma tumor syndrome: how oral clinicians may save lives
Authors: Fardal Øystein , Nevland Kristian , Johannessen Anne Christine , Vetti Hildegunn Høberg 
Published: March 2022

AbstractIntroductionPatients with the PTEN hamartoma tumor syndrome (PHTS) have an 81%–90% cumulative lifetime risk of developing cancer. Around 90% of these patients have recognizable oral features. Receiving a diagnosis may save these patients’ lives. This is the first presentation of a family with the PHTS diagnosis with focus on the oral and periodontal findings and treatments.Case PresentationAll three children (one son and two daughters) inherited the same heterozygous variant in the PTEN gene from their father. Gingival overgrowth was observed in all patients in addition to macrocephaly. Other findings included fissured tongue, high arched palate, papules, and trichilemmomas. The father had experienced severe tooth loss. Surgery was performed to treat the gingival overgrowth and periodontal pockets; however, the treatment was characterized by multiple recurrences of the overgrowth.ConclusionsOral changes, macrocephaly, tumors, and/or a family history of benign or malignant lesions are important features that oral clinicians should be aware of for a possible PHTS diagnosis. Patients suspected of having PHTS should be referred to a medical practitioner, specifically a geneticist, for further diagnostic investigations. The periodontal problems seemed to be difficult to control for these patients. They will likely need an active and frequent maintenance therapy to control the persistent inflammation and gingival overgrowth. In addition, they need a thorough monitoring for benign or malignant changes in the orofacial regions.Why are these cases new information?

Oral features are found in 90% of the cases with the PHTS diagnosis.
The periodontal findings showed a persistent recurrence of gingival overgrowth with a strong probability of serious periodontal diseases.What are the keys to successful management of these cases?

A suspicion of a PHTS diagnosis with a referral to a medical practitioner, specifically a geneticist, for complete workup may help save these patients' lives.
Close monitoring during maintenance therapy with re‐treatment as needed to prevent further periodontal complications.
Continued monitoring and treatment throughout the patient's lifetime for development of recurrent or new, benign or malignant lesions at relevant sites.What are the primary limitations to success in these cases?

A failure to identify the PHTS syndrome with the accompanying oral and periodontal complications. Complications may lead to a delay in appropriate treatment.
Inability to control the persistent gingival overgrowth and a deteriorating periodontal condition.
A failure to discover benign and malignant lesions in the orofacial region.
Family functioning and eating disorders treatment in a partial hospitalization program in adolescent females with eating disorders
Authors: Liu Jianyi , Rockwell Roxanne E. , Kaye Walter H. , Wierenga Christina E. , Brown Tiffany A. 
Published: March 2022

AbstractObjectivePrevious research examining family functioning in eating disorder (ED) treatment has focused primarily on outpatient settings. However, few studies have examined this aspect in partial hospitalization programs. To address this gap, this study examined family functioning over the course of an ED partial hospitalization program (PHP) in adolescent females (M(SD) age = 15.66 (1.50)).MethodParticipants (n = 105) completed the Family Assessment Device and Eating Disorder Examination Questionnaire at treatment admission, 1‐month post‐admission, and discharge.ResultsResults from repeated measures analysis of variance indicated adolescents perceived an improvement in family functioning regarding Communication, Affective Responsiveness, and Behavioral Control through 1‐year follow‐up (p values < .05). Neither family functioning at admission nor change in family functioning in the first month correlated with any outcomes (weight, ED symptoms, and remission).DiscussionResults support that family functioning does not contribute to ED severity, and that treatment can improve adolescent perception of family functioning. Given the importance of involving the family in ED treatment, identifying mediators of treatment outcomes is critical to improve treatment efficacy.Public SignificanceAdolescents in a partial hospital program (PHP) for eating disorders (EDs) perceived improvements in their family communication, behavior, and ability to process appropriate emotions from admission to 1‐year post‐treatment, although these aspects did not significantly predict treatment outcomes. The findings provide helpful information for future research on adolescents with EDs in higher levels of care and underscore the importance of exploring mechanisms of family‐based treatment in PHP.
Amp 1q21 is more predictable with dismal survival than gain 1q21 of newly diagnosed multiple myeloma in real‐world analysis
Authors: Wang Yu‐tong , Bao Li , Chu Bin , Chen Xiao‐huan , Lu Min‐qiu , Shi Lei , Gao Shan , Fang Li‐juan , Xiang Qiu‐qing , Ding Yue‐hua 
Published: March 2022

AbstractIntroductionThe gain/amplification (amp) of 1q21 is one of the most common high‐risk chromosome abnormality (HRCA) in multiple myeloma (MM). The prognostic value of 1q21+ remains to be controversial on the status of gain or amp and the combination of other HRCAs.MethodsIn this retrospective study, we included 318 newly diagnosed MM (NDMM) patients who had fluorescence in situ hybridization (FISH) data and treated with novel agents in our department.ResultsOur study noted MM patients with amp 1q21 were more likely accompanied with t(4;14), t(14;16), and t(14;20). Patients with amp 1q21 presented with elder age, advanced Revised International Staging System (R‐ISS) stages, anemia, and more plasma cells in bone marrow compared to patients with gain 1q21 alone and no 1q21+. Moreover, amp 1q21 alone correlated with shorter progression‐free survival (PFS) (22.8m vs. 40.5m vs. 39.6m) and overall survival (OS) (45.2m vs. NA vs. 83.5m) compared with gain 1q21 alone and no FISH abnormalities. Although the high ratio of proteasome inhibitor and immunomodulatory drugs used in patients with amp 1q21, the overall response (ORR) was the lowest compared with no 1q21+ and gain 1q21. Multivariate analysis defined amp 1q21 as an independent prognostic marker for NDMM patients, rather than gain 1q21.ConclusionThe amp 1q21 predict inferior treatment response and survival, especially coexisted with high‐risk IgH translocation.
Tumor necrosis factor‐alpha stimulated gene‐6: A biomarker reflecting disease activity in rheumatoid arthritis
Authors: Hu Tingting , Liu Yuhan , Li Xu , Li Xiaohang , Liu Yanzhao , Wang Qunxia , Huang Jiayi , Yu Jianlin , Wu Yang , Chen Simei , Zeng Tingting , Tan Liming 
Published: March 2022

AbstractBackgroundTo explore the serum tumor necrosis factor‐alpha stimulated gene‐6 (TSG‐6) level and its association with disease activity in rheumatoid arthritis (RA) patients.MethodsWe recruited 176 RA patients, 178 non‐RA patients (lupus erythematosus, osteoarthritis, ulcerative colitis, ankylosing spondylitis and psoriasis) and 71 healthy subjects. Serum TSG‐6 levels were detected by enzyme‐linked immunosorbent assay (ELISA). RA patients were divided into inactive RA and active RA groups by disease activity score of 28 joints based on C‐reactive protein (DAS28‐CRP). The receiver operating characteristic (ROC) curve and Spearman's rank correlation test analyzed the correlation between TSG‐6 concentration and RA disease activity.ResultsTumor necrosis factor‐alpha stimulated gene‐6 levels in the RA group were increased (p < 0.01). TSG‐6 concentrations indicated an upward tendency with increased disease activity; The area under the curve (AUC) of TSG‐6 for diagnosing RA and assessing the severity of RA were 0.78 and 0.80, respectively; The combination of TSG‐6 and anti‐mutated citrullinated vimentin antibodies (anti‐MCV) (sensitivity:98.4%)improved the diagnostic accuracy of RA. Binary logistic regression analysis showed that TSG‐6 was an independent risk factor related to the severity of RA, and OR (95% CI) was 1.2 (1.003–1.453).ConclusionThe TSG‐6 levels in RA patients were elevated and related to disease activity. Therefore, TSG‐6 may serve as a new potential biomarker for evaluating RA disease activity.
Preparation and Assessment of Nitric Oxide‐Releasing Small‐Diameter Collagen‐Based Vascular Graft for Vascular Regeneration Applications
Authors: Xu Yue , Jiang Xia , Niu Chuan , Yang Shaojie , Xiao Xiong , Huang Ziwei , Feng Li 
Published: March 2022

AbstractEndothelialization and antithrombosis are the keys for small‐diameter vascular grafts to reduce thromboembolism and intimal hyperplasia and achieve revascularization. Nitric oxide (NO) is an essential antiplatelet, proendothelialization, and vasodilating agent. Meanwhile, owing to its good biocompatibility, collagen is long considered a feasible material for manufacturing small‐diameter vascular grafts. However, thrombosis and poor mechanical strength remain major drawbacks. A collagen methacrylamide‐co‐selenocysteine (Col‐MA‐Se) composite capable of catalyzing NO release is synthesized here. The Col‐MA‐Se composite improves the blood compatibility of collagen and stimulates the migration and growth of endothelial cells, which suggests that the Col‐MA‐Se composite is suitable for small‐diameter vascular grafts. The prepared composite is then incorporated with polycaprolactone (PCL) to prepare small‐diameter vascular grafts that satisfying basic mechanical requirements for transplantation, followed by a comprehensive exploration of its mechanical strength, endothelial cell response, and platelet behavior. Results confirm the successful construction of collagen/PCL vascular grafts capable of releasing NO and affording rapid endothelialization and antithrombosis, which indicate their promising application prospects for vascular regeneration.
Process safety education: Validating the concepts for a process safety program (article 2/2)
Authors: Boogaerts Geert , Toeter Lisanne 
Published: March 2022

AbstractThis article focusses on the validation of the concepts that deserve integration in, for example, an Advanced Master of Safety Engineering program. The selection of the concepts was described in the previous article “Process safety education: Selecting the concepts for a process safety program.” This historical and theoretical selection process of process safety concepts needs a validation by the industry and review by root cause analysis of recent major incidents and accidents. The finally selected, reviewed, and adjusted list of concepts are the backbone to build on and improve short and 1‐year academic process safety courses and programs as well as industrial process safety trainings. Apart from the validation of the selected concepts, the industry validation also resulted in an extension and clarification of the concepts by experts in the subject matter and the desired competencies and characteristics of a young engineer educated in the process safety concepts.
How financial performance influences investment in sustainable development initiatives in the airline industry: The moderation role of state‐ownership
Authors: Abdi Yaghoub , Li Xiaoni , Càmara‐Turull Xavier 
Published: March 2022

AbstractThis study aims to broaden the research on the influence of financial performance (FP) on sustainable development activities proxied by environmental, social, and governance (ESG) disclosure in the airline industry. In addition, we examine the moderating effect of state‐ownership on the FP‐ESG relationship. Based on data collected from 36 airlines worldwide for the period 2008–2019, we found that ESG is negatively and significantly influenced by FP. This result implies that the willingness of airlines to contribute to ESG initiatives is diminished when economic conditions are favorable. State‐ownership moderates the relationship between FP and ESG such that the negative relationship is weaker in presence of state shares. Our findings help to disentangle the roles of FP in its contribution to sustainability and are valuable in better understanding the topic in airline context. Also, our results have some important implications for how industry practitioners may act more effectively in the managerial social decision process and provide insights to assist investors who are considering eco‐investing in the airline industry.
Agent-Based Stochastic Simulation of Emotions
Authors: Barachini Franz , Stary Christian 
Published: March 2022

AbstractIn this chapter, we model jealousy of agent-based stochastic interactions from a very different perspective. We study the impact of jealousy to cooperation models by using dynamic artificial agents and agent populations following combined characteristics. We simulate a dynamic multi-player public goods game, and we use the Business Transaction Theory as a basic layer for information valuation.
Gravitational soft theorem from emergent soft gauge symmetries
Authors: Beneke Martin , Hager Patrick , Szafron Robert 
Published: March 2022

Abstract
We consider and derive the gravitational soft theorem up to the sub-subleading power from the perspective of effective Lagrangians. The emergent soft gauge symmetries of the effective Lagrangian provide a transparent explanation of why soft graviton emission is universal to sub-subleading power, but gauge boson emission is not. They also suggest a physical interpretation of the form of the soft factors in terms of the charges related to the soft transformations and the kinematics of the multipole expansion. The derivation is done directly at Lagrangian level, resulting in an operatorial form of the soft theorems. In order to highlight the differences and similarities of the gauge-theory and gravitational soft theorems, we include an extensive discussion of soft gauge-boson emission from scalar, fermionic and vector matter at subleading power.
HER2-positive apocrine carcinoma of the breast: a population-based analysis of treatment and outcome
Authors: Skenderi Faruk , Alahmad Mohamad Alhoda Mohamad , Tahirovic Emin , Alahmad Yaman M. , Gatalica Zoran , Vranic Semir 
Published: March 2022

Abstract
Purpose
Apocrine carcinoma of the breast (APO) expresses HER2 in 30–50% of cases. This study explored the clinicopathological features and outcome of HER2+/APO and matched HER2+/NST cohort.

Methods
We used the SEER database to explore the cohorts. Univariate and multivariate analyses were used to assess the survival. Based on ER and PR [steroid receptors/SR/] and HER2 status, we divided the cohorts to match the intrinsic molecular subtypes for comparisons.

Results
We retrieved 259 cases of HER2+/APO. Most HER2+/APO were SR negative (65%). HER2+/APO were more prevalent in the 80+ age group (24.7% vs. 15.7%, p < 0.001). HER2+/SR−/APO had a significantly lower histological grade than the HER2+/SR−/NST (p < 0.001). Breast cancer-related deaths were more prevalent in HER2+/NST (7.8% vs. 3.9%, p = 0.019). This was particularly evident between SR− subgroups (10.4% in HER2+/SR−/NST vs. 4.2% in HER2+/SR−/APO, p = 0.008) and was reaffirmed in breast cancer-specific survival in univariate analysis (p = 0.03). Other than race and SR status, HER2+/APO subgroups did not differ in clinicopathological parameters.

Conclusions
Our study confirms the rarity of the APO and reveals that SR status in APO does not affect these patients' prognosis. HER2+/APO tumors tend to have a less aggressive phenotype and a more favorable outcome despite a markedly lower ER/PR positivity.
Search-based fairness testing for regression-based machine learning systems
Authors: Perera Anjana , Aleti Aldeida , Tantithamthavorn Chakkrit , Jiarpakdee Jirayus , Turhan Burak , Kuhn Lisa , Walker Katie 
Published: March 2022

Abstract
Context
Machine learning (ML) software systems are permeating many aspects of our life, such as healthcare, transportation, banking, and recruitment. These systems are trained with data that is often biased, resulting in biased behaviour. To address this issue, fairness testing approaches have been proposed to test ML systems for fairness, which predominantly focus on assessing classification-based ML systems. These methods are not applicable to regression-based systems, for example, they do not quantify the magnitude of the disparity in predicted outcomes, which we identify as important in the context of regression-based ML systems.

Method:
We conduct this study as design science research. We identify the problem instance in the context of emergency department (ED) wait-time prediction. In this paper, we develop an effective and efficient fairness testing approach to evaluate the fairness of regression-based ML systems. We propose fairness degree, which is a new fairness measure for regression-based ML systems, and a novel search-based fairness testing (SBFT) approach for testing regression-based machine learning systems. We apply the proposed solutions to ED wait-time prediction software.

Results:
We experimentally evaluate the effectiveness and efficiency of the proposed approach with ML systems trained on real observational data from the healthcare domain. We demonstrate that SBFT significantly outperforms existing fairness testing approaches, with up to 111% and 190% increase in effectiveness and efficiency of SBFT compared to the best performing existing approaches.

Conclusion:
These findings indicate that our novel fairness measure and the new approach for fairness testing of regression-based ML systems can identify the degree of fairness in predictions, which can help software teams to make data-informed decisions about whether such software systems are ready to deploy. The scientific knowledge gained from our work can be phrased as a technological rule; to measure the fairness of the regression-based ML systems in the context of emergency department wait-time prediction use fairness degree and search-based techniques to approximate it.
Whether weather causes contention: assessing the ongoing resilience opportunity of telecommuting
Authors: Budnitz Hannah , Tranos Emmanouil , Chapman Lee 
Published: March 2022

AbstractThe Covid-19 pandemic resulted in an unprecedented overnight explosion in telecommuting. It has highlighted a new dependence on digital infrastructures and raised new questions regarding the resilience of internet connectivity as an alternative to travel. Pre-pandemic, we considered how telecommuting could offer an opportunity for resilience when travel was disrupted by weather extremes. We analysed five years’ of recorded broadband speed variation across England and Wales in order to quantify the changing demand for internet access during the working day under adverse weather conditions. Slower broadband speeds, also known as contention, are an indication of increased demand. Thus, during the working day, contention is an indication that external factors like weather can influence the choice to telecommute instead of travel. A multilevel regression model is estimated to investigate the relationship between contention during the working day and weather, whilst controlling for background spatial and demographic differences in internet services. Emergent patterns suggest that even before the pandemic, online connectivity was in greater demand when travel was disrupted or at risk of disruption. Our research provides insights into the roles that both the supply of and the demand for transport and digital technologies might play in increasing resilience and maintaining productivity during severe weather and other disruptions as experience of both types of working has become so widespread.
Absence of Street Lighting May Prevent Vehicle Crime, but Spatial and Temporal Displacement Remains a Concern
Authors: Tompson Lisa , Steinbach Rebecca , Johnson Shane D. , Teh Chun Siong , Perkins Chloe , Edwards Phil , Armstrong Benedict 
Published: March 2022

Abstract
Objectives
This paper estimates the effect of changes in street lighting at night on levels of crime at street-level. Analyses investigate spatial and temporal displacement of crime into adjacent streets.

Methods
Offense data (burglaries, robberies, theft of and theft from vehicles, and violent crime) were obtained from Thames Valley Police, UK. Street lighting data (switching lights off at midnight, dimming, and white light) were obtained from local authorities. Monthly counts of crime at street-level were analyzed using a conditional fixed-effects Poisson regression model, adjusting for seasonal and temporal variation. Two sets of models analyzed: (1) changes in night-time crimes adjusting for changes in day-time crimes and (2) changes in crimes at all times of the day.

Results
Switching lights off at midnight was strongly associated with a reduction in night-time theft from vehicles relative to daytime (rate ratio RR 0.56; 0.41–0.78). Adjusted for changes in daytime, night-time theft from vehicles increased (RR 1.55; 1.14–2.11) in adjacent roads where street lighting remained unchanged.

Conclusion
Theft from vehicle offenses reduced in streets where street lighting was switched off at midnight but may have been displaced to better-lit adjacent streets. Relative to daytime, night-time theft from vehicle offenses reduced in streets with dimming while theft from vehicles at all times of the day increased, thus suggesting temporal displacement. These findings suggest that the absence of street lighting may prevent theft from vehicles, but there is a danger of offenses being temporally or spatially displaced.