bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerosity tuning in human association cortices and local image contrast representations in early visual cortex
Authors: Paul Jacob M. , van Ackooij Martijn , ten Cate Tuomas C. , Harvey Ben M. 
Published: March 2022

AbstractHuman early visual cortex response amplitudes monotonically increase with numerosity (object number), regardless of object size and spacing. However, numerosity is typically considered a high-level visual or cognitive feature, while early visual responses follow image contrast in the spatial frequency domain. We find that, at fixed contrast, aggregate Fourier power (at all orientations and spatial frequencies) follows numerosity closely but nonlinearly with little effect of object size, spacing or shape. This would allow straightforward numerosity estimation from spatial frequency domain image representations. Using 7T fMRI, we show monotonic responses originate in primary visual cortex (V1) at the stimulus’s retinotopic location. Responses here and in neural network models follow aggregate Fourier power more closely than numerosity. Truly numerosity tuned responses emerge after lateral occipital cortex and are independent of retinotopic location. We propose numerosity’s straightforward perception and neural responses may result from the pervasive spatial frequency analyses of early visual processing.
Electro-assisted printing of soft hydrogels via controlled electrochemical reactions
Authors: Da Silva Aruã Clayton , Wang Junzhi , Minev Ivan Rusev 
Published: March 2022

AbstractHydrogels underpin many applications in tissue engineering, cell encapsulation, drug delivery and bioelectronics. Methods improving control over gelation mechanisms and patterning are still needed. Here we explore a less-known gelation approach relying on sequential electrochemical–chemical–chemical (ECC) reactions. An ionic species and/or molecule in solution is oxidised over a conductive surface at a specific electric potential. The oxidation generates an intermediate species that reacts with a macromolecule, forming a hydrogel at the electrode–electrolyte interface. We introduce potentiostatic control over this process, allowing the selection of gelation reactions and control of hydrogel growth rate. In chitosan and alginate systems, we demonstrate precipitation, covalent and ionic gelation mechanisms. The method can be applied in the polymerisation of hybrid systems consisting of more than one polymer. We demonstrate concomitant deposition of the conductive polymer Poly(3,4-ethylenedioxythiophene) (PEDOT) and alginate. Deposition of the hydrogels occurs in small droplets held between a conductive plate (working electrode, WE), a printing nozzle (counter electrode, CE) and a pseudoreference electrode (reference electrode, RE). We install this setup on a commercial 3D printer to demonstrate patterning of adherent hydrogels on gold and flexible ITO foils. Electro-assisted printing may contribute to the integration of well-defined hydrogels on hybrid electronic-hydrogel devices for bioelectronics applications.
Growth of Neogene Andes linked to changes in plate convergence using high-resolution kinematic models
Authors: Quiero Felipe , Tassara Andrés , Iaffaldano Giampiero , Rabbia Osvaldo 
Published: March 2022

AbstractThe Andean cordillera was constructed during compressive tectonic events, whose causes and controls remain unclear. Exploring a possible link to plate convergence has been impeded by the coarse temporal resolution of existing plate kinematic models. Here we show that the Neogene evolution of the Andean margin is primarily related to changes in convergence as observed in new high-resolution plate reconstructions. Building on a compilation of plate finite rotations spanning the last 30 million years and using noise-mitigation techniques, we predict several short-term convergence changes that were unresolved in previous models. These changes are related to main tectono-magmatic events and require forces that are compatible with a range of geodynamic processes. These results allow to revise models of ongoing subduction orogeny at its type locality, emphasizing the role of upper plate deformation in the balance between kinematic energy associated with plate motion and gravitational potential energy stored in orogenic crustal roots.
A national survey of physical activity after spinal cord injury
Authors: Soriano Jan Elaine , Squair Jordan W. , Cragg Jacquelyn J. , Thompson Jennifer , Sanguinetti Rafael , Vaseghi Bita , Emery Carolyn A. , Grant Christopher , Charbonneau Rebecca , Larkin-Kaiser Kelly A. , Phillips Aaron A. , Dujic Zeljko 
Published: March 2022

AbstractPhysical activity is a powerful modifiable risk factor for disease and mortality. Physical activity levels in people with spinal cord injury (SCI) have not been quantified relative to uninjured individuals in a large population-based sample. We aimed to quantify and compare physical activity in people with and without SCI, and to examine the associations between physical activity, lifestyle, and socioeconomic factors. The 2010 Canadian Community Health Survey (n > 57,000) was used, which includes three measures that assess physical activity levels (i.e., leisure time activity frequency, leisure time activity intensity, and transportation time activity intensity). Bivariable and multivariable logistic regressions were performed and odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were estimated. The odds of physical activity in people with SCI were 0.43 (95% CI 0.3–0.61), 0.53 (95% CI 0.36–0.75), and 0.42 (95% CI 0.28–0.61), across the three measures of physical activity, respectively. These differences persisted after adjustment for lifestyle, comorbidities, and socioeconomic factors. Physical activity is reduced in the SCI population compared with the general population. This knowledge is important to direct future research and guide the allocation of health care resources.
Cross-scale energy cascade powered by magnetospheric convection
Authors: Ukhorskiy Aleksandr Y. , Sorathia Kareem A. , Merkin Viacheslav G. , Crabtree Chris , Fletcher Alex C. , Malaspina David M. , Schwartz Steven J. 
Published: March 2022

AbstractPlasma convection in the Earth’s magnetosphere from the distant magnetotail to the inner magnetosphere occurs largely in the form of mesoscale flows, i.e., discrete enhancements in the plasma flow with sharp dipolarizations of magnetic field. Recent spacecraft observations suggest that the dipolarization flows are associated with a wide range of kinetic processes such as kinetic Alfvén waves, whistler-mode waves, and nonlinear time-domain structures. In this paper we explore how mesoscale dipolarization flows produce suprathermal electron instabilities, thus providing free energy for the generation of the observed kinetic waves and structures. We employ three-dimensional test-particle simulations of electron dynamics one-way coupled to a global magnetospheric model. The simulations show rapid growth of interchanging regions of parallel and perpendicular electron temperature anisotropies distributed along the magnetic terrain formed around the dipolarization flows. Unencumbered in test-particle simulations, a rapid growth of velocity-space anisotropies in the collisionless magnetotail plasma is expected to be curbed by the generation of plasma waves. The results are compared with in situ observations of an isolated dipolarization flow at one of the Magnetospheric Multiscale Mission spacecraft. The observations show strong wave activity alternating between broad-band wave activity and whistler waves. With estimated spatial extent being similar to the characteristic size of the temperature anisotropy patches in our test-particle simulations, the observed bursts of the wave activity are likely to be produced by the parallel and perpendicular electron energy anisotropies driven by the dipolarization flow, as suggested by our modeling results.
Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates
Authors: Garaizar Adiran , Espinosa Jorge R. , Joseph Jerelle A. , Collepardo-Guevara Rosana 
Published: March 2022

AbstractBiomolecular condensates formed by the process of liquid–liquid phase separation (LLPS) play diverse roles inside cells, from spatiotemporal compartmentalisation to speeding up chemical reactions. Upon maturation, the liquid-like properties of condensates, which underpin their functions, are gradually lost, eventually giving rise to solid-like states with potential pathological implications. Enhancement of inter-protein interactions is one of the main mechanisms suggested to trigger the formation of solid-like condensates. To gain a molecular-level understanding of how the accumulation of stronger interactions among proteins inside condensates affect the kinetic and thermodynamic properties of biomolecular condensates, and their shapes over time, we develop a tailored coarse-grained model of proteins that transition from establishing weak to stronger inter-protein interactions inside condensates. Our simulations reveal that the fast accumulation of strongly binding proteins during the nucleation and growth stages of condensate formation results in aspherical solid-like condensates. In contrast, when strong inter-protein interactions appear only after the equilibrium condensate has been formed, or when they accumulate slowly over time with respect to the time needed for droplets to fuse and grow, spherical solid-like droplets emerge. By conducting atomistic potential-of-mean-force simulations of NUP-98 peptides—prone to forming inter-protein $$\beta$$
β
-sheets—we observe that formation of inter-peptide $$\beta$$
β
-sheets increases the strength of the interactions consistently with the loss of liquid-like condensate properties we observe at the coarse-grained level. Overall, our work aids in elucidating fundamental molecular, kinetic, and thermodynamic mechanisms linking the rate of change in protein interaction strength to condensate shape and maturation during ageing.
Ultraslow light realization using an interacting Bose–Einstein condensate trapped in a shallow optical lattice
Authors: Mikaeili H. , Dalafi A. , Ghanaatshoar M. , Askari B. 
Published: March 2022

AbstractIn this article, we propose an experimentally feasible scheme for the ultraslow light realization based on the optomechanically induced transparency (OMIT) phenomenon using a hybrid optomechanical system consisting of a one-dimensional Bose–Einstein condensate trapped in a shallow optical lattice considering the nonlinear effect of atom-atom interaction. It is shown how the system can switch from the normal mode splitting to the OMIT regime by manipulation of the s-wave scattering frequency of atomic collisions when the cavity is pumped at a fixed rate. Then, it is shown that an ultraslow light with a time delay more than 150 ms corresponding to a group velocity about 1 mm/s is achievable by controlling the optical lattice depth as well as the strength of atom-atom interaction and the number of atoms. Importantly, such an ultraslow light is detectable in the output of the cavity since it occurs in the frequency region of coupling-probe detuning where the reflection coefficient of the cavity is maximum.
Infant infections, respiratory symptoms, and allergy in relation to timing of rice cereal introduction in a United States cohort
Authors: Moroishi Yuka , Signes-Pastor Antonio J. , Li Zhigang , Cottingham Kathryn L. , Jackson Brian P. , Punshon Tracy , Madan Juliette , Nadeau Kari , Gui Jiang , Karagas Margaret R. 
Published: March 2022

AbstractRice products marketed in the USA, including baby rice cereal, contain inorganic arsenic, a putative immunotoxin. We sought to determine whether the timing of introduction of rice cereal in the first year of life influences occurrence of infections, respiratory symptoms, and allergy. Among 572 infants from the New Hampshire Birth Cohort Study, we used generalized estimating equation, adjusted for maternal smoking during pregnancy, marital status, education attainment, pre-pregnancy body mass index, maternal age at enrollment, infant birth weight, and breastfeeding history. Among 572 infants, each month earlier of introduction to rice cereal was associated with increased risks of subsequent upper respiratory tract infections (relative risk, RR = 1.04; 95% CI: 1.00–1.09); lower respiratory tract infections (RR = 1.19; 95% CI: 1.02–1.39); acute respiratory symptoms including wheeze, difficulty breathing, and cough (RR = 1.10; 95% CI: 1.00–1.22); fever requiring a prescription medicine (RR = 1.22; 95% CI: 1.02–1.45) and allergy diagnosed by a physician (RR = 1.20; 95% CI: 1.06–1.36). No clear associations were observed with gastrointestinal symptoms. Our findings suggest that introduction of rice cereal earlier may influence infants’ susceptibility to respiratory infections and allergy.
Methylation at CpG sites related to growth differentiation factor-15 was not prospectively associated with cardiovascular death in discordant monozygotic twins
Authors: Moore Spencer Shawn , Mukherji Pallavi , Leung Ming , Vrentas Catherine E. , Mwanja Melsa M. , Dai Jun 
Published: March 2022

AbstractMyocardial infarction patients had decreased methylation at four growth differentiating factor-15 (GDF-15) related CpG sites (cg13033858, cg16936953, cg17150809, and cg18608055). These sites had not been studied for their association with cardiovascular disease (CVD) deaths. Thus, we aimed to assess the associations independent of genes, shared environment, and traditional CVD risk factors. Nineteen white, male, monozygotic twin pairs discordant for CVD deaths were included from the National Heart, Lung and Blood Institute Twin Study (NHLBI) initiated in 1969. Data on vital status was collected through December 31, 2014. Methylation of buffy coat DNA at exam 3 (1986–87) was measured using the Illumina HumanMethylation450 BeadChip. Principal component analysis was used to generate a score representing blood leukocyte composition and baseline CVD risk factors and predominated with natural killer cells, CD4+ T cells, and Framingham risk score. Conditional logistic regression demonstrated that methylation at the four CpG sites was not associated with CVD deaths before (all p > 0.05, bootstrapped p > 0.05) and after adjustment for the score (all p > 0.05). Joint influences of cg16936953 and the score were statistically significant (p < 0.05). In conclusion, joint influences of methylation at the site cg16936953 and the score are prospectively associated with CVD deaths independent of germline and common environment.ClinicalTrials.gov Identifier for NHLBI Twin Study: NCT00005124.
Strain-level profiling of viable microbial community by selective single-cell genome sequencing
Authors: Hosokawa Masahito , Endoh Taruho , Kamata Kazuma , Arikawa Koji , Nishikawa Yohei , Kogawa Masato , Saeki Tatsuya , Yoda Takuya , Takeyama Haruko 
Published: March 2022

AbstractCulture-independent analysis with high-throughput sequencing has been widely used to characterize bacterial communities. However, signals derived from non-viable bacteria and non-cell DNA may inhibit its characterization. Here, we present a method for viable bacteria-targeted single-cell genome sequencing, called PMA-SAG-gel, to obtain comprehensive whole-genome sequences of surviving uncultured bacteria from microbial communities. PMA-SAG-gel uses gel matrixes that enable sequential enzymatic reactions for cell lysis and genome amplification of viable single cells from the microbial communities. PMA-SAG-gel removed the single-amplified genomes (SAGs) derived from dead bacteria and enabled selective sequencing of viable bacteria in the model samples ofEscherichia coliandBacillus subtilis. Next, we demonstrated the recovery of near-complete SAGs of eight oxygen-tolerant bacteria, includingBacteroidesspp. andPhocaeicolaspp., from 1331 human feces SAGs. We found the presence of two different strains in each species and identified their specific genes to investigate the metabolic functions. The survival profile of an entire population at the strain level will provide the information for understanding the characteristics of the surviving bacteria under the specific environments or sample processing and insights for quality assessment of live bacterial products or fecal microbiota transplantation and for understanding the effect of antimicrobial treatments.
Cadmium adsorption performance and mechanism from aqueous solution using red mud modified with amorphous MnO2
Authors: Pang Yin , Zhao Cong , Li Yao , Li Qin , Bayongzhong Xiang , Peng Daoping , Huang Tao 
Published: March 2022

AbstractIn this study, red mud modified by manganese dioxide(MRM) was utilized as an adsorbent to effectively remove Cd2+ from aqueous solution. The characteristics were analysed by SEM–EDS, XRD, BET, FTIR and XPS. Different factors that affected the Cd2+ removal on MRM, such as dosage, initial pH, initial Cd2+ concentration, were investigated using batch adsorption experiments. Simultaneously, the adsorption kinetics, adsorption isotherms and adsorption thermodynamics of Cd2+ were also investigated using adsorption experiments data. The characterization results showed that MRM had a rougher, larger specific surface area and pore volume (38.91 m2 g−1, 0.02 cm3 g−1) than RM (10.22 m2 g−1, 0.73 cm3 g−1). The adsorption experiments found that the equilibrium adsorption capacity of MRM for Cd2+ was significantly increased to 46.36 mg g−1, which was almost three times that of RM. According to the fitting results, the pseudo-second-order kinetic model described the adsorption process better than the pseudo-first-order kinetic model. The Langmuir model fitted the adsorption isotherms well, indicating that the adsorption process was unimolecular layer adsorption and the maximum capacity was 103.59 mg g−1. The thermodynamic parameters indicated that the adsorption process was heat-trapping and spontaneous. Finally, combined XPS and FTIR studies, it was speculated that the adsorption mechanisms should be electrostatic attachment, specific adsorption (i.e., Cd–O or hydroxyl binding) and ion exchange. Therefore, manganese dioxide modified red mud can be an effective and economical alternative to the removal of Cd2+ in the wastewater treatment process.
Evaluation of metallic trace elements contents in some major raw foodstuffs in Burkina Faso and health risk assessment
Authors: Bazié Bazoin Sylvain Raoul , Compaoré Muller Kiswendsida Abdou , Bandé Moumouni , Kpoda Stephane Dissinviel , Méda Naamwin-So-Bawfu Romaric , Kangambega Tebkieta Marceline Ouedraogo , Ilboudo Inoussa , Sandwidi Barkissa Yonaba , Nikiema Fulbert , Yakoro Alphonse , Bassolé Imaël Henri Nestor , Hien Hervé , Kabré Elie 
Published: March 2022

AbstractDiet based on cereal, vegetables, oleaginous and dried fish are providing essential metallic elements. It can be also a source of exposure to toxic metallic elements. The aims of this study were to evaluate the contents on nine metallic trace elements (Fe, Zn, Mn, Co, Cd, Pb, Cu, Ni, Cr) in some major raw foodstuffs including rice, maize, peanut, tomato and dried fish in Burkina Faso and assess the health risk of these elements. Two hundred twenty-two samples were collected and analyzed by atomic absorption spectrometry. The health risk assessment was based on the United States Environment Protection Agency (USEPA) model. Iron and Zinc were the elements with the highest concentrations in the investigated foodstuffs. The iron highest median value (68.80 mg/kg) was observed in dried fish followed by maize (43.09 mg/kg) and peanuts (28.92 mg/kg). Rates of 77.95%, 66.66% and 32.5% obtained respectively fro tomato, maize and rice samples were above the maximum limit of lead set by Codex Alimentarius while 47.6%, 71.16% and 0% of maize, tomato and rice samples respectively have shown concentration above the maximum limit of cadmium. Chromium had shown higher contribution rate to the maximum daily intake of 167.11%, 34%, 2% and 8.53% for rice, maize and peanut respectively. A non-cancer risk situation has been observed on rice, maize and peanut consumption. None of the index risk values was above the threshold set by USEPA.
Quality of life in patients treated with radiochemotherapy for primary diagnosis of anal cancer
Authors: Sauter Christina , Peeken Jan C. , Borm Kai , Diehl Christian , Münch Stefan , Combs Stephanie E. , Dapper Hendrik 
Published: March 2022

AbstractAnal cancer and the related treatment are generally known to affect patients’ quality of life. The aim of this study was to assess self-reported quality of life (QoL) of anal cancer patients after combined radiation and chemotherapy, and to identify patient-, disease-, and therapy-related factors associated with QoL. A total of 94 patients treated with definitive chemoradiation for anal cancer at our institution in the period from 2004 to 2018 were identified from our database. QoL was assessed in the remaining 52 patients using the EORTC QLQ-C30 questionnaire (cancer-specific QoL) and the newly developed anal cancer module QLQ-ANL27 (site-specific QoL). Differences in QoL between anal cancer patients and a German age and sex adjusted reference population were examined. The median follow-up was 71 months (range, 7–176). In the cancer-specific QoL module, the anal cancer cohort presented with significantly lower scores in role (− 12.2 points), emotional (− 6.6 points), and social functioning (− 6.8 points), but higher scores in diarrhea (+ 36.3 points) and constipation (+ 13.3 points) than the German reference population. There were no significant differences in disease- or therapy-related factors, but age greater than 70 years and a follow-up time greater than 71 months had a negative impact on global QoL. As for the site-specific QoL, patients with a tumor relapse showed significantly higher symptom scores than patients with a complete clinical remission in all scales except of micturition frequency. Compared to 3D conformal radiotherapy, IMRT treatment seemed to improve non-stoma bowel function (+ 23.3 points), female sexual functioning (+ 24.2 points), and came along with less scores in the symptom scales pain (− 35.9 points), toilet proximity (− 28.6 points), and cleanliness (− 26.2 points). Most of the functional scores of anal cancer patients were lower compared to the general German population, but did not seem to affect the general QoL. Fatigue, physical, and role functioning had the strongest impact on global QoL causing psychological symptoms as important as physical.