bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosomatic Symptoms: Resilience as a Protective Factor in Adolescents. Observational, Descriptive, Cross-Sectional, and Multicenter Study
Authors: Fuentes-Chacón Rosa Mª , Simón-Saiz Mª José , Díaz-Valentín Mª José , Rodriguez-Sánchez Mª José , Martínez-García Rosa Mª , Garrido-Abejar Margarita 
Published: March 2022

Abstract
Background
Psychosomatic symptoms—clinical manifestations without a clear pathological origin—have a high prevalence in adolescents. However, most studies are oriented towards the search for risk factors and very few have approached the subject by examining which elements may be protective. The objective of this current work was to identify whether there is an association between the presence of psychosomatic symptoms and the capacity for resilience in adolescents.
Methods
This was an observational, descriptive, cross-sectional, and multicenter study carried out at five different schools in Cuenca (Spain). The sample comprised 844 adolescents aged 15 to 18 years who were in the 3rd or 4th years of compulsory secondary education or the 1st or 2nd years of the baccalaureate. At each academic level, groups were randomly selected for administration of the Psychosomatic Problems Scale and 10-Item Connor–Davidson Resilience Scale (to determine psychosomatic symptoms and resilience, respectively); sociodemographic data were also recorded.
Results
Girls overall, and adolescents aged 17–18 years, presented significantly higher psychosomatic symptoms. Being more resilient was negatively correlated with all the psychosomatic symptoms. The strongest correlation was between ‘felt sad’ and ‘concentrating difficulties’ and the multivariate analysis, which controlled for sex and age, predicted fewer psychosomatic symptoms among the most resilient individuals.
Conclusions
Psychosomatic symptoms are frequently observed in the adolescent population and are often expressions that make emotional distress visible. The capacity for resilience positively affected emotional well-being and reduced the risk of presenting psychosomatic symptoms in our study population.
Repopulated microglia induce expression of Cxcl13 with modest changes in Tau phosphorylation but do not impact amyloid pathology
Authors: O'Banion M. Kerry , Karaahmet Berke , Le Linh , Mendes Monique S. , Majewska Ania K. 
Published: March 2022

Abstract
Background: Adult microglia rely on self-renewal through division to repopulate and sustain their numbers. However, with aging, microglia display morphological and transcriptional changes that reflect a heightened state of neuroinflammation. This state threatens aging neurons and other cells and can influence the progression of Alzheimer's disease (AD). In this study, we sought to determine whether renewing the microglia through a forced partial depletion/repopulation method could attenuate AD pathology in the 3xTg and APP/PS1 mouse models.Methods: We pharmacologically depleted the microglia of two cohorts of 21-22 month old 3xTg mice and one cohort of 14 month old APP/PS1 mice using PLX5622 formulated in chow for 2 weeks. Following depletion, we returned the mice to standard chow diet for 1 month to allow microglial repopulation. We assessed the effect of depletion and repopulation on AD pathology, microglial gene expression, and surface expression of homeostatic markers on microglia using immunohistochemistry, single-cell RNAseq and flow cytometry.Results: Although we did not identify a significant impact of microglial repopulation on amyloid pathology in either of the AD models, we observed a modest but significant increase in specific isoforms of phosphorylated-Tau species after repopulation in the 3xTg mice. We provide evidence that repopulated microglia in the hippocampus exhibited changes in the expression of homeostatic microglial markers. Lastly, we identified novel subpopulations of microglia by performing single-cell RNAseq analysis on CD45int/+ cells from hippocampi of control and repopulated 3xTg mice. In particular, one subpopulation induced after repopulation is characterized by heightened expression of Cxcl13.Conclusion: Overall, we found that depleting and repopulating microglia alters their phenotype and causes overexpression of microglial Cxcl13 with disparate effects on Tau and amyloid pathologies.
Prenatal vitamin intake in first month of pregnancy and DNA methylation in cord blood and placenta in two prospective cohorts
Authors: Dou John F. , Middleton Lauren Y.M. , Zhu Yihui , Benke Kelly S. , Feinberg Jason I. , Croen Lisa A. , Hertz-Picciotto Irva , Newschaffer Craig J. , LaSalle Janine M. , Fallin Daniele , Schmidt Rebecca J. , Bakulski Kelly M. 
Published: March 2022

Abstract
Background
Prenatal vitamin use is recommended before and during pregnancies for normal fetal development. Prenatal vitamins do not have a standard formulation, but many contain calcium, folic acid, iodine, iron, omega-3 fatty acids, zinc, and vitamins A, B6, B12, and D, and usually they contain higher concentrations of folic acid and iron than regular multivitamins in the U.S. Nutrient levels can impact epigenetic factors such as DNA methylation, but relationships between maternal prenatal vitamin use and DNA methylation have been relatively understudied. We examined use of prenatal vitamins in the first month of pregnancy in relation to cord blood and placenta DNA methylation in two prospective pregnancy cohorts: the Early Autism Risk Longitudinal Investigation (EARLI) and Markers of Autism Risk Learning Early Signs (MARBLES) studies.
Results
In placenta, prenatal vitamin intake was marginally associated with − 0.52% (95% CI: -1.04, 0.01) lower mean array-wide DNA methylation in EARLI, and associated with − 0.60% (-1.08, -0.13) lower mean array-wide DNA methylation in MARBLES. There was little consistency in the associations between prenatal vitamin intake and single DNA methylation site effect estimates across cohorts and tissues, with only a few overlapping sites with correlated effect estimates. However, the single DNA methylation sites with p-value < 0.01 (EARLI cord nCpGs =4,068, EARLI placenta nCpGs =3,647, MARBLES cord nCpGs =4,068, MARBLES placenta nCpGs =9,563) were consistently enriched in neuronal developmental pathways.
Conclusions
Together, our findings suggest that prenatal vitamin intake in the first month of pregnancy may be related to lower placental global DNA methylation and related to DNA methylation in brain-related pathways in both placenta and cord blood.
Improving Treatment Outcomes for Adolescents with Borderline Personality Disorder Through a Socioecological Approach
Authors: Bo Sune , Sharp Carla , Kongerslev Mickey T. , Luyten Patrick , Fonagy Peter 
Published: March 2022

Abstract
Background: There is a dearth of studies evaluating treatment efficacy for adolescents diagnosed with borderline personality disorder. The few available randomized controlled trials that have been conducted show modest results and treatments appear to have equivalent effects. The current paper draws on (a) the lessons learnt from the last 50 years of psychotherapy research in general and (b) recent advances in mentalization-based understanding of why treatment works, which together point to the importance of following a socioecological approach in the treatment of personality problems in adolescence – a developmental period that insists on a treatment approach that goes beyond the therapist-client dyad. Case presentation: Here, we describe such an approach, and offer a clinical case example with a young 17-year old girl diagnosed with borderline personality disorder, to illustrate what a shift toward a more socioecological approach would entail. Conclusions: The clinical impact of the socioecological approach and the potential benefits as illustrated in the current case illustration, offers a framework that justifies and allows for the expansion of service delivery for youth with borderline personality disorder beyond dyadic therapist-client work.
Inequitable Access: Factors Associated with Incomplete Referrals to Pediatric Cardiology
Authors: Warren Paul W , Beck Andrew F , Zang Huaiyu , Anderson Jeffrey , Statile Christopher 
Published: March 2022

Abstract
Objective: To assess the variables associated with unscheduled and incomplete cardiology clinic visits among referred pediatric patients with a focus on equity gaps. Study Design: We conducted a retrospective chart review for patients less than 18 years of age who were referred to cardiology clinics at a single quaternary referral center from 2017 to 2019. We collected patient demographic data including race, an index of neighborhood socioeconomic deprivation linked to a patient’s geocoded address, referral information, and cardiology clinic information. The primary outcome was an incomplete clinic visit. The secondary outcome was an unscheduled appointment. Independent associations were identified using multivariable logistic regression. Results: There were 10,610 new referrals; 6,954 (66%) completed new cardiology clinic visits. Black race (OR 1.41; 95% CI 1.22-1.63), public insurance (OR 1.29; 95% CI 1.14-1.46), and a higher deprivation index (OR 1.32; 95% CI 1.08-1.61) were associated with higher odds of incomplete visit compared to the respective reference groups of White race, private insurance, and a lower deprivation index. The findings for unscheduled visit were similar. A shorter time elapsed from the initial referral to when the appointment was made was associated with lower odds of incomplete visit (OR 0.62; 95% CI 0.52-0.74).Conclusion: Race, insurance type, neighborhood deprivation, and time from referral date to appointment made were each associated with incomplete referrals to pediatric cardiology. Interventions directed to understand such associations and respond accordingly could help to equitably improve referral completion.
Antireflection of Optical Anisotropic Dielectric Metasurfaces
Authors: Liao Yu-Hsuan , Hsu Wei-Lun , Wang Chin-Ming 
Published: March 2022

Abstract
We propose a hetero-nano-fin structure to further improve the efficiency of Pancharatnam–Berry phase metasurfaces. Two hetero-nano-fin types, MgF2/GaN and MgF2/Nb2O5, were investigated. The overall polarization conversion efficiency (PCE) improved from 52.7% to 54% for the MgF2/GaN nano-fin compared with the bare GaN nano-fin. The overall PCE of the Nb2O5 nano-fin was 1.7 times higher than that of the GaN nano-fin. The overall PCE improved from 92.4% up to 96% after the application of MgF2 antireflection. Although the increment of energy seems minimal, antireflection is crucial for a metasurface, not only enhancing efficiency but also reducing background signal of a meta-device.
An experimental study in Real-time Facial Emotion Recognition on 3RL dataset
Authors: Zafra Rahmeh Abou , Abdullah Lana Ahmad , Alaaraj Rouaa , Albezreh Rasha , Barhoum Tarek , Jallad Khloud Al 
Published: March 2022

Abstract
Although real-time facial emotion recognition is a hot topic research domain in the field of human-computer interaction, state-of-the-art available datasets still suffer from various problems such as some unrelated photos like document photos, unbalanced number of photos in each class, and some misleading images that can affect negatively on correct classification. 3RL dataset was created which contains about 24K images and will be publically available, to overcome previously available datasets problems. 3RL dataset is labelled with five basic emotions: happiness, fear, sadness, disgust, and anger. Moreover, we compared 3RL dataset with other most famous state-of-the-art datasets (FER dataset, CK+ dataset), we have applied the most common used algorithms in previous works, SVM and CNN. Results have shown a noticeable improvement of generalization on 3RL dataset. Experiments have shown an accuracy of up to 91.4% on 3RL dataset using CNN where results on FER2013, CK+ are respectively (approximately from 60% to 85%).
(-)-Epigallocatechin Gallate Attenuates Spinal Motoneuron Death Induced by Brachial Plexus Root Avulsion in Rats
Authors: Lu Fatai , Zhang Guodong , Zhu Yingkang , Liu Zunpeng 
Published: March 2022

Abstract
Background EGCG benefits a variety of insults. Methods Rats were randomized into: EGCG, Avulsion, and Sham. Results P-c-Jun-positive motoneurons and the ratio of p-c-Jun/c-Jun were significantly lower in EGCG group at 3d and 7d after injury. Conclusions EGCG protected motoneurons
Microcontroller Implementation of Current Modulated Edge Emitting Semiconductor Lasers with Pulse Packages and Chimera States in Its Network
Authors: Ramachandran Dhanagopal , Saeed Nasr , Tchamda André Rodrigue , Kingni Sifeu Takougang , Karthikeyan Anitha , Hussain Iqtadar 
Published: March 2022

Abstract
This paper investigates the dynamical behavior of a single and a network of current modulated edge emitting semiconductor lasers (CMEESLs). Different dynamical behaviors of CMEESL are revealed in two-dimensional parameters space by varying the amplitude and frequency of modulation. Single CMEESL exhibits periodic pulse packages followed by period-doubling cascade to chaotic pulse packages for frequency of modulation current density less than 1 GHz. Microcontroller results which agree with numerical results of single CMEESL are presented. To investigate the dynamics in a network of CMEESLs, a nonlocally coupled lattice array of CMEESLs is analyzed numerically by varying the coupling strength. It is found that the coupling strength plays a significant role in the coherent and incoherent behaviors of the nodes in the network. For a small range of coupling strength, the network exhibits chimera states which are confirmed by their respective state plots. Synchronization error between the nonlocally coupled CMEESLs is also presented to show the existence of chimera states.
Monitoring of SARS-CoV-2 in wastewater: what normalisation for improved understanding of epidemic trends?
Authors: Sakarovitch Charlotte , Schlosser Olivier , Courtois Sophie , Proust-Lima Cécile , Couallier Joanne , Pétrau Agnès , Litrico Xavier , Loret Jean-François 
Published: March 2022

AbstractSARS-CoV-2 RNA quantification in wastewater has emerged as a relevant additional means to monitor the COVID-19 pandemic. However, the concentration can be affected by black water dilution factors or movements of the sewer shed population, leading to misinterpretation of measurement results. The aim of this study was to evaluate the performance of different indicators to accurately interpret SARS-CoV-2 in wastewater. Weekly/bi-weekly measurements from three cities in France were analysed from February to September 2021. The concentrations of SARS-CoV-2 gene copies were normalised to the faecal-contributing population using simple sewage component indicators. To reduce the measurement error, a composite index was created to combine simultaneously the information carried by the simple indicators. The results showed that the regularity (mean absolute difference between observation and the smoothed curve) of the simple indicators substantially varied across sampling points. The composite index consistently showed better regularity compared to the other indicators and was associated to the lowest variation in correlation coefficient across sampling points. These findings suggest the recommendation for the use of a composite index in wastewater-based epidemiology to compensate for variability in measurement results.
Medicinal Herbs from Phytoinformatics: An Aid for Skin Burn
Management
Authors: Sharma Ruby , Tanwar Ankit , Sharma Deepti , Jain Sapna , Mishra Amit Kumar 
Published: March 2022

Abstract:
Skin burn injury is the most common cause of trauma that is still considered a dreadful
condition in healthcare emergencies around the globe. Due to the availability of a variety of regimes,
their management remains a dynamical challenge for the entire medical and paramedical community.
Indeed, skin burn injuries are accompanied by a series of several devastating events that lead to
sepsis and multiple organ dysfunction syndromes. Hence, the challenge lies in the development of a
better understanding as well as clear diagnostic criteria and predictive biomarkers, which are
important in their management. Though there are several regimes available in the market, there are
still numerous limitations and challenges in the management. In this review article, we have
discussed the various biomarkers that could be targeted for managing skin burn injuries. Instead of
focusing on allopathic medication that has its adverse events per se, we have discussed the history,
ethnopharmacology properties, and prospects of identified phytomedicines from a well-established
herbal informatics model. This review article not only discusses the benefits of scrutinized
phytocompounds but also the development of novel druggable phyto-compounds to target skin burn
injury at a lower cost with no adverse effects.
Recent Advances in Rhodanine-Based Compounds as Potential Antimicrobial Agents
Authors: Mohamed Yasser M.A. , Solum Eirik 
Published: March 2022

Abstract:
Microbial resistance towards antibiotics has become a global threat to human health.
There is currently an urgent need to develop novel antibacterial and antifungal agents with new
mechanisms of antimicrobial action and lower levels of toxicity. This paper reviews the structureactivity
relationship as well as the antimicrobial effect of substituted rhodanine derivatives. The
inhibitory effects of the substituted rhodanines on different, specific antibacterial targets and the
potential that rhodanine-derived compounds have to be new antibacterial compounds have been
discussed in detail.
Xylopic Acid Suppresses Adjuvant-induced Arthritis in Sprague Dawley
Rats via Reduction in Serum Levels of IL-6 and TNF-alpha
Authors: Osafo Newman , Antwi Aaron O. , Otu-Boakye Sarah 
Published: March 2022

Background:
Xylopic acid (XA) is the principal constituent obtained from the biofractionation
of the dried fruits of Xylopia aethiopica. Our initial reports have established the acute
anti-inflammatory activity of this kaurene diterpene.

Objective:
Currently, we investigate the chronic anti-inflammatory activity of xylopic acid.

Method:
The adjuvant-induced arthritis model in rats was employed in carrying out the study.

Results:
It was observed from the study that XA significantly (P < 0.05) suppressed the oedema
associated with adjuvant arthritis while preventing associated joint deformation as identified from
the radiographs. Histopathological analysis of joints of treated animals revealed signs of bone
reformation and re-calcification following XA administration. From the haematological analysis,
xylopic acid significantly decreased eosinophil sedimentation rate (ESR) while also decreasing
white blood cells (WBC), which were increased after arthritis induction. Serum analysis showed
the inhibitory effect of XA on serum expression of IL-6 and TNF-alpha in arthritic rats.

Conclusion::
Our study demonstrates the anti-arthritic activity of orally administered XA while
pointing to a possible mechanism of its anti-inflammatory action.
The Influence of Al3+ Metal Ion in AlCl3 Compound On α- Amylase Enzyme Activity
Authors: Chasanah Choirul , Salirawati Das 
Published: March 2022

The influence of Al3+ metal ion in AlCl3 towards α-amylase enzyme activity have been studied. The activity of the α-amylase enzyme on potato starch substrate was determined using the DNS method (3,5-dinitrosalicylic acid) at optimum conditions. The data analysis was conducted in a descriptive qualitative manner. The results obtained that α-amylase enzyme activity with potato starch substrate was optimum at 20 mg/mL with pH 7.2, incubation temperature 37˚C, incubation time 15 minutes, and enzyme concentration of 40 mg/mL with an average enzyme activity value of 0.0079 mg/mL/minute at 37˚C. However, after the addition of Al3+ metal ion, the average value of enzyme activity decreased. These means that empirically Al3+ metal ion has a tendency to be inhibitory to the α-amylase enzyme activity on potato starch substrates.
Penyelesaian Masalah Perturbasi pada Persamaan Difusi Konveksi menggunakan Metode Formal Expansion
Authors: Nurfadhilah Destia , Binatari Nikenasih 
Published: March 2022

Perambatan panas merupakan contoh kasus pemodelan persamaan diferensial parsial yang aplikasinya banyak ditemukan dalam kehidupan sehari-hari. Salah satunya persamaan difusi konveksi. Pada penelitian ini, akan dibahas mengenai penyelesaian masalah perturbasi pada persamaan difusi konveksi dengan menggunakan metode formal expansion. Pada pemodelan digunakan prinsip konservatif dengan asumsi batang logam homogen dan kecepatan fluida yang bernilai sangat kecil. Syarat batas yang digunakan adalah syarat batas Dirichlet homogen. Metode formal expansion dilakukan derat melakukan pendekatan deret taylor pada solusi fungsi di sekitar nilai perturbasi sama dengan nol. Dengan menyamakan koefisien pada suku epsilon berpangkat, diperoleh 3 jenis masalah nilai awal syarat batas. Ketiga jenis masalah tersebut kemudian dicari solusi eksak menggunakan metode separasi varibel dan metode ekspansi fungsi eigen. Darisini, solusi eksak dari persamaan difusi konveksi diperoleh.
Kematangan Gonad Ikan Cempedik (Osteochilus spilurus, Bleeker 1851) pada Musim Penghujan di Sungai Lenggang, Belitung Timur
Authors: Rizkika Neri , Fakhrurrozi Yulian , Kurniawan Andri , Kurniawan Ardiansyah 
Published: March 2022

Ikan Cempedik (Osteochilus spilurus) merupakan salah satu jenis ikan air tawar lokal yang penting di Pulau Belitung. Nilai ekonomi yang tinggi dan permintaan konsumsi menjadi potensi pembangunan dan bencana bagi keanekaragaman hayati air tawar. Salah satu data biologis terkait upaya pemanfaatan secara berkelanjutan adalah aspek reproduksi. Ruang lingkup penelitian ini dibatasi pada ikan yang ditangkap pada musim hujan pada bulan Desember 2015 dan Desember 2016. Musim penghujan merupakan musim penangkapan Ikan Cempedik di Sungai Lenggang, Kabupaten Belitung Timur. Pengamatan tingkat kematangan gonad dilakukan secara visual dan indeks kematangan gonadnya diketahui melalui perbandingan bobot tubuh dan bobot gonad ikan. Ikan Cempedik pada musim hujan memasuki masa pemijahan dengan tingkat kematangan gonad III dan IV. Ikan dengan TKG IV mencapai 94% pada sampling tahun 2015 saat bulan Desember memiliki curah hujan tertinggi. Nilai indeks kematangan di bawah 20% dan tergolong ikan yang dapat bertelur lebih dari satu kali dalam setahun. Fekunditas ikan dengan TKG IV sebanyak 1.196 -10.947 pada tahun 2015 dan 951 - 2.060 untuk tahun 2016.