bluuebunny/crossref_metadata_2025_split huggingface dataset:
Networked lymphatic endothelial cells in a transplanted cell sheet contribute to form functional lymphatic vessels
Authors: Nagahara Ayumi Inoue , Homma Jun , Ryu Bikei , Sekine Hidekazu , Higashi Yuhei , Shimizu Tatsuya , Kawamata Takakazu 
Published: December 2022

AbstractThis study evaluated whether cell sheets containing a network of lymphatic endothelial cells (LECs) promoted lymphangiogenesis after transplantation in vivo. Cell sheets with a LEC network were constructed by co-culturing LECs and adipose-derived stem cells (ASCs) on temperature-responsive culture dishes. A cell ratio of 3:2 (vs. 1:4) generated networks with more branches and longer branch lengths. LEC-derived lymphatic vessels were observed 2 weeks after transplantation of a three-layered cell sheet construct onto rat gluteal muscle. Lymphatic vessel number, diameter and depth were greatest for a construct comprising two ASC sheets stacked on a LEC/ASC (3:2 ratio) sheet. Transplantation of this construct in a rat model of femoral lymphangiectomy led to the formation of functional lymphatic vessels containing both transplanted and host LECs. Further development of this technique may lead to a new method of promoting lymphangiogenesis.
Strain tunable quantum emission from atomic defects in hexagonal boron nitride for telecom-bands
Authors: Shaik Akbar Basha Dhu-al , Palla Penchalaiah 
Published: December 2022

AbstractThis study presents extending the tunability of 2D hBN Quantum emitters towards telecom (C-band − 1530 to 1560 nm) and UV-C (solar blind − 100 to 280 nm) optical bands using external strain inducements, for long- and short-range quantum communication (Quantum key distribution (QKD)) applications, respectively. Quantum emitters are the basic building blocks of this QKD (quantum communication or information) technologies, which need to emit single photons over room temperature and capable of tuning the emission wavelength to the above necessary range. Recent literature revealed that quantum emitters in 2D hBN only has the ability to withstand at elevated temperatures and aggressive annealing treatments, but density functional theory (DFT) predictions stated that hBN can only emit the single photons from around 290 to 900 nm (UV to near-IR regions) range. So, there is a need to engineer and further tune the emission wavelength of hBN quantum emitters to the above said bands (necessary for efficient QKD implementation). One of the solutions to tune the emission wavelength is by inducing external strain. In this work, we examine the tunability of quantum emission in hBN with point defects by inducing three different normal strains using DFT computations. We obtained the tunability range up to 255 nm and 1589.5 nm, for the point defects viz boron mono vacancies (VB) and boron mono vacancies with oxygen atoms (VBO2) respectively, which can enhance the successful implementation of the efficient QKD. We also examine the tunability of the other defects viz. nitrogen mono vacancies, nitrogen mono vacancy with self-interstitials, nitrogen mono vacancy with carbon interstitials, carbon dimers and boron dangling bonds, which revealed the tunable quantum emission in the visible, other UV and IR spectrum ranges and such customized quantum emission can enhance the birth of other quantum photonic devices.
Long non-coding RNAs as the regulatory hubs in rice response to salt stress
Authors: Mirdar Mansuri Raheleh , Azizi Amir-Hossein , Sadri Amir-Hossein , Shobbar Zahra-Sadat 
Published: December 2022

AbstractSalinity seriously constrains growth and fertility of rice worldwide. Long non-coding RNAs (lncRNAs) play crucial roles in plant abiotic stress response. However, salt responsive lncRNAs are poorly understood in rice. Herein, salt responsive lncRNAs (DE-lncRNAs) were identified in FL478 (salt tolerant) compared to its susceptible parent (IR29) using RNA-seq in root tissues at seedling stage. In FL478 and IR29, 8724 and 9235 transcripts with length of > 200 bp were nominated as potential lncRNAs, respectively. Rigorous filtering left four (in FL478) and nine (in IR29) DE-lncRNAs with only 2 DE-lncRNAs in common. ATAC-seq data showed that the genomic regions of all four lncRNAs in FL478 and 6/9 in IR29 are significantly accessible for transcription. Weighted correlation network analysis (WGCNA) revealed that lncRNA.2-FL was highly correlated with 173 mRNAs as trans-targets and a gene encoding pentatricopeptide repeat (PPR) protein was predicted as cis-target of lncRNA.2-FL. In silico mutagenesis analysis proposed the same transcription factor binding sites (TFBSs) in vicinity of the trans- and cis-regulatory target genes of lncRNA.2-FL, which significantly affect their transcription start site (TSS). This study provides new insights into involvement of the DE-lncRNAs in rice response to salt stress. Among them, lncRNA.2-FL may play a significant regulatory role in the salt stress tolerance of FL478.
Driving pressure-guided ventilation improves homogeneity in lung gas distribution for gynecological laparoscopy: a randomized controlled trial
Authors: Zhang Wei , Liu Feifei , Zhao Zhanqi , Shao Chunqing , Xu Xin , Ma Jiajia , Han Ruquan 
Published: December 2022

AbstractTo investigate whether driving pressure–guided ventilation could contribute to a more homogeneous distribution in the lung for gynecological laparoscopy. Chinese patients were randomized, after pneumoperitoneum, to receive either positive end expiratory pressure (PEEP) of 5 cm H2O (control group), or individualized PEEP producing the lowest driving pressure (titration group). Ventilation homogeneity is quantified as the global inhomogeneity (GI) index based on electrical impedance tomography, with a lower index implying more homogeneous ventilation. The perioperative arterial oxygenation index and respiratory system mechanics were also recorded. Blood samples were collected for lung injury biomarkers including interleukin-10, neutrophil elastase, and Clara Cell protein-16. A total of 48 patients were included for analysis. We observed a significant increase in the GI index immediately after tracheal extubation compared to preinduction in the control group (p = 0.040) but not in the titration group (p = 0.279). Furthermore, the GI index was obviously lower in the titration group than in the control group [0.390 (0.066) vs 0.460 (0.074), p = 0.0012]. The oxygenation index and respiratory compliance were significantly higher in the titration group than in the control group. No significant differences in biomarkers or hemodynamics were detected between the two groups. Driving pressure–guided PEEP led to more homogeneous ventilation, as well as improved gas exchange and respiratory compliance for patients undergoing gynecological laparoscopy.Trial Registration: ClinicalTrials.gov NCT04374162; first registration on 05/05/2020.
Real-time, multi-spectral motion artefact correction and compensation for laser speckle contrast imaging
Authors: Heeman Wido , Maassen Hanno , Dijkstra Klaas , Calon Joost , van Goor Harry , Leuvenink Henri , van Dam Gooitzen. M. , Boerma E. Christiaan 
Published: December 2022

AbstractLaser speckle contrast imaging (LSCI) is so sensitive to motion that it can measure the movement of red blood cells. However, this extreme sensitivity to motion is also its pitfall as the clinical translation of LSCI is slowed down due to the inability to deal with motion artefacts. In this paper we study the effectiveness of a real-time, multi-spectral motion artefact correction and compensation by subduing an in vitro flow phantom and ex vivo porcine kidney to computer-controlled motion artefacts. On the in vitro flow phantom, the optical flow showed a good correlation with the total movement. This model results in a better signal-to-noise ratios for multiple imaging distances and the overestimation of perfusion was reduced. In the ex vivo kidney model, the perfusion overestimation was also reduced and we were still able to distinguish between ischemia and non-ischemia in the stabilized data whereas this was not possible in the non-stabilized data. This leads to a notably better perfusion estimation that could open the door to a multitude of new clinical applications for LSCI.
Intense chorus waves are the cause of flux-limiting in the heart of the outer radiation belt
Authors: Chakraborty S. , Mann I. R. , Watt C. E. J. , Rae I. J. , Olifer L. , Ozeke L. G. , Sandhu J. K. , Mauk B. H. , Spence H. 
Published: December 2022

AbstractChorus waves play a key role in outer Van Allen electron belt dynamics through cyclotron resonance. Here, we use Van Allen Probes data to reveal a new and distinct population of intense chorus waves excited in the heart of the radiation belt during the main phase of geomagnetic storms. The power of the waves is typically ~ 2–3 orders of magnitude greater than pre-storm levels, and are generated when fluxes of ~ 10–100 keV electrons approach or exceed the Kennel–Petschek limit. These intense chorus waves rapidly scatter electrons into the loss cone, capping the electron flux to a value close to the limit predicted by Kennel and Petschek over 50 years ago. Our results are crucial for understanding the limits to radiation belt fluxes, with accurate models likely requiring the inclusion of this chorus wave-driven flux-limiting process, that is independent of the acceleration mechanism or source responsible for enhancing the flux.
Hypoxia, acidification and oxidative stress in cells cultured at large distances from an oxygen source
Authors: D’Aiuto Natali , Hochmann Jimena , Millán Magdalena , Di Paolo Andrés , Bologna-Molina Ronell , Sotelo Silveira José , Arocena Miguel 
Published: December 2022

AbstractHypoxia is a condition frequently encountered by cells in tissues, whether as a normal feature of their microenvironment or subsequent to deregulated growth. Hypoxia can lead to acidification and increased oxidative stress, with profound consequences for cell physiology and tumorigenesis. Therefore, the interplay between hypoxia and oxidative stress is an important aspect for understanding the effects of hypoxic microenvironments on cells. We have used a previously developed variant of the method of coverslip-induced hypoxia to study the process of acidification in a hypoxic microenvironment and to simultaneously visualize intracellular levels of hypoxia and oxidative stress. We observed high accumulation of CO2in hypoxic conditions, which we show is the main contributor to acidification in our model. Also, increased levels of oxidative stress were observed in moderately hypoxic cells close to the oxygen source, where the mitochondrial membrane potential was preserved. Conversely, cells at large distances from the oxygen source showed higher levels of hypoxia, milder oxidative stress and reduced mitochondrial membrane potential. Our results contribute to characterize the interplay between reduced oxygen levels, acidification and oxidative stress in a simple in vitro setting, which can be used to model cell responses to an altered environment, such as the early tumor microenvironment.
A fast kernel independence test for cluster-correlated data
Authors: Song Hoseung , Liu Hongjiao , Wu Michael C. 
Published: December 2022

AbstractCluster-correlated data receives a lot of attention in biomedical and longitudinal studies and it is of interest to assess the generalized dependence between two multivariate variables under the cluster-correlated structure. The Hilbert–Schmidt independence criterion (HSIC) is a powerful kernel-based test statistic that captures various dependence between two random vectors and can be applied to an arbitrary non-Euclidean domain. However, the existing HSIC is not directly applicable to cluster-correlated data. Therefore, we propose a HSIC-based test of independence for cluster-correlated data. The new test statistic combines kernel information so that the dependence structure in each cluster is fully considered and exhibits good performance under high dimensions. Moreover, a rapid p value approximation makes the new test fast applicable to large datasets. Numerical studies show that the new approach performs well in both synthetic and real world data.
Socio-economic inequalities in minimum dietary diversity among Bangladeshi children aged 6–23 months: a decomposition analysis
Authors: Kundu Satyajit , Das Pranta , Rahman Md. Ashfikur , Al Banna Md. Hasan , Fatema Kaniz , Islam Md. Akhtarul , Srivastava Shobhit , Muhammad T. , Dey Rakhi , Hossain Ahmed 
Published: December 2022

AbstractThis study aimed to measure the socio-economic inequalities in having minimum dietary diversity (MDD) among Bangladeshi children aged 6–23 months as well as to determine the factors that potentially contribute to the inequity. The Bangladesh Demographic and Health Survey (BDHS) 2017–2018 data were used in this study. A sample of 2405 (weighted) children aged 6–23 months was included. The overall weighted prevalence of MDD was 37.47%. The concentration index (CIX) value for inequalities in MDD due to wealth status was positive and the concentration curve lay below the line of equality (CIX: 0.1211, p < 0.001), where 49.47% inequality was contributed by wealth status, 25.06% contributed by the education level of mother, and 20.41% contributed by the number of ante-natal care (ANC) visits. Similarly, the CIX value due to the education level of mothers was also positive and the concentration curve lay below the line of equality (CIX: 0.1341, p < 0.001), where 52.68% inequality was contributed by the education level of mother, 18.07% contributed by wealth status, and 14.69% contributed by the number of ANC visits. MDD was higher among higher socioeconomic status (SES) groups. Appropriate intervention design should prioritize minimizing socioeconomic inequities in MDD, especially targeting the contributing factors of these inequities.
Myopia: why the retina stops inhibiting eye growth
Authors: Swiatczak Barbara , Schaeffel Frank 
Published: December 2022

AbstractIn myopia, the eye grows too long, and the image projected on the retina is poorly focused when subjects look at a distance. While the retina normally controls eye growth by visual processing, it seems to give up during myopia development. But what has changed? To determine whether the sharp image is in front or behind the retinal plane, a comparison of image sharpness in red and blue would provide a reliable cue because focal planes are about 1.3 D apart due to longitudinal chromatic aberration (LCA). However, up to now, it could not be demonstrated that the retina does, in fact, such a comparison. We used a new approach: movies were digitally filtered in real time to present either the blue channel of the RGB color format unfiltered while green and red were blurred (“blue in focus”), or the red channel was unfiltered while green and blue were blurred (“red in focus”) accordingly to the human LCA function. Here we show that, even though filtered movies looked similar, eyes became significantly shorter when the movie was sharp in the red plane but became longer when it was presented sharp in the blue plane. Strikingly, the eyes of young subjects who were already myopic did not respond at all—showing that their retina could no longer decode the sign of defocus based on LCA. Our findings resolve a long-standing question as to how the human retina detects the sign of defocus. It also suggests a new non-invasive strategy to inhibit early myopia development: keeping the red image plane on a computer screen sharp but low pass filtering the blue.
High-resolution tracking of hyrax social interactions highlights nighttime drivers of animal sociality
Authors: Bordes Camille N. M. , Beukeboom Rosanne , Goll Yael , Koren Lee , Ilany Amiyaal 
Published: December 2022

AbstractNetwork structure is a key driver of animal fitness, pathogen transmission, information spread, and population demographics in the wild. Although a considerable body of research applied network analysis to animal societies, only little effort has been devoted to separate daytime and nighttime sociality and explicitly test working hypotheses on social structures emerging at night. Here, we investigated the nighttime sociality of a wild population of rock hyraxes (Procavia capensis) and its relation to daytime social structure. We recorded nearly 15,000 encounters over 27 consecutive days and nights using proximity loggers. Overall, we show that hyraxes are more selective of their social affiliates at night compared to daytime. We also show that hyraxes maintain their overall network topology while reallocating the weights of social relationships at the daily and monthly scales, which could help hyraxes maintain their social structure over long periods while adapting to local constraints and generate complex social dynamics. These results suggest that complex network dynamics can be a by-product of simple daily social tactics and do not require high cognitive abilities. Our work sheds light on the function of nighttime social interactions in diurnal social species.
Promoting economic and environmental resilience in the post-COVID-19 era through the city and regional on-road fuel sustainability development
Authors: Yang Chuxiao , Wu Haitao , Guo Yunxia , Hao Yu , Wang Zhaohua 
Published: December 2022

AbstractHow to control the global temperature rise within 1.5 °C in the post-COVID-19 era has attracted attention. Road transport accounts for nearly a quarter of global CO2 emissions, and the related sulfur dioxide (SO2) emissions also trigger air pollution issues in population-intensive cities and areas. Many cities and states have announced a timetable for phasing out urban-based fossil fuel vehicles. By combining a Markov-chain model with a dynamic stochastic general equilibrium (DSGE) model, the impacts of on-road energy structural change led by phasing out fossil fuel vehicles in the road transportation sector are evaluated. The impact of automobile emissions (both CO2 and SO2) on the environment is evaluated, taking into consideration of variation between cities, regions, and countries. Two other major driving forces in addition to CO2 emissions reduction in promoting fossil fuel vehicles’ transition toward net-zero carbon are identified and analyzed with multiple different indicators. Under the framework of the DSGE model, climate policy instruments’ effects on economic development, energy consumption, and their link to economic and environmental resilience are evaluated under exogenous shocks as well.
Effect of grip-enhancing agents on sliding friction between a fingertip and a baseball
Authors: Yamaguchi Takeshi , Nasu Daiki , Masani Kei 
Published: December 2022

AbstractFriction between a pitcher’s fingers and the leather surface of a baseball is a key factor that influences ball delivery, causing Major League Baseball in the United States to recently enhance enforcement of rules banning the unauthorized use of friction-enhancing agents or sticky substances. Here, we examine how the application of rosin powder and sticky substances alters the friction coefficient between a fingertip and the leather of a baseball. We find that sticky substances increase friction which can positively affect ball spin rate, while rosin has the advantage of keeping friction consistent within and between individuals. Additionally, we find that baseballs used by the Nippon Professional Baseball Organization in Japan are less slippery compared with the ones used in Major League Baseball, suggesting that grip-enhancers may have a larger impact on friction for baseballs used in the United States compared to Japan. Furthermore, our results indicate that changing the characteristics of the leather the baseball is made from may increase friction, reducing the unauthorized use of sticky substances.
A bottom‐up design methodology of neural min‐sum decoders for LDPC codes
Authors: Li Guangwen , Yu Xiao , Luo Yuan , Wei Guangfen 
Published: December 2022

AbstractIt is known the belief propagation variants of linear codes can be readily unrolled as neural networks, after assigning learnable weights on the message‐passing edges. Contrary to the conventional top‐down training process, where the distillation occurs in the form of pruning or sharing when downsizing model is required, a new bottom‐up design methodology to augment performance of the raw min‐sum decoder of LDPC codes is proposed, by introducing incrementally a few parameters in the specific positions of corresponding neural network. Then a novel postprocessing method, devised to further improve performance, can cope with decoding failures effectively. In the training process, a simplified scheme of generating training data is presented via exploiting an approximation to the targeted mixture density, and it is found the evaluation of trained parameters converges after sufficient iterations, indicating its generality with an arbitrary designated number of iterations. Lastly, an extensive simulation of three codes carried on the AWGN or Rayleigh fading channels demonstrates the design reaches a good tradeoff of low‐complexity and comparable decoding performance.
Design procedure and optimisation methodology of permanent magnet synchronous machines with direct slot cooling for aviation electrification
Authors: Tameemi Ahmed , Degano Michele , Murataliyev Mukhammed , Di Nardo Mauro , Valente Giorgio , Gerada David , Xu Zeyuan , Gerada Chris 
Published: December 2022

AbstractElectric machines are widely employed in a variety of sectors, including automotive and aerospace industry. With the rising trend towards electrification in aviation, electric machines with increased power density and efficiency are becoming key enabling technologies, requiring the development of innovative design procedures. In this study, a preliminary design procedure for Surface Mounted Permanent Magnet Synchronous Machines (SPMSMs) intensively cooled by means of oil channels placed in the stator slots is proposed. The analytical derivation of SPMSM sizing equations, including the sub‐domain model and optimisation algorithm will be reported in detail. Indeed, both the electromagnetic and thermal equations of the machine are considered for the derivation of the sizing tool. As a result, the latter allows to capture variation of the machine design not only in terms of mechanical demands, such as power and speed, but also in terms of coolant characteristics, and can be effectively employed to perform trade‐off studies at a preliminary design stage. The proposed design tool will be used for a specific case study: The design of a high‐speed machine for an aerospace hydraulic actuator. The accuracy of the proposed design tool is validated for different parameters by comparing the results to experimental measurements performed on an existing 8‐pole 9‐slot prototype SPMSM.