bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of optical coherence tomography-detected calcified nodules using coronary computed tomography angiography
Authors: Sugiura Junichi , Watanabe Makoto , Nobuta Saki , Okamura Akihiko , Kyodo Atsushi , Nakamura Takuya , Nogi Kazutaka , Ishihara Satomi , Hashimoto Yukihiro , Ueda Tomoya , Seno Ayako , Onoue Kenji , Soeda Tsunenari , Saito Yoshihiko 
Published: August 2022

Abstract
Diagnosis of Calcified nodules (CNs) is critical in proper management of coronary artery disease but CNs can be detected only using intracoronary imaging modalities. This study aimed to investigate the ability of coronary computed tomography angiography (CCTA) in predicting CNs detected by optical coherence tomography (OCT). In total, 138 patients (249 vessels) who underwent OCT after CCTA evaluation were retrospectively enrolled and classified into CN (11 patients / 12 vessels) and non-CN (127 patients / 237 vessels) groups based on the OCT analysis. Retrospective CCTA analysis revealed that coronary artery calcification score (CACS), calcified plaque volume (CPV), non-calcified plaque volume (NCPV), low-attenuation plaque volume (LAPV), and maximum calcified plaque area (MCPA) in the target vessel were significantly larger in the CN group than in non-CN group. Receiver operating characteristic curve indicated that CACS ≥ 162 (area under the ROC curve (AUC 0.86, sensitivity 83.3%, specificity 71.3%), CPV ≥ 20.2 mm3 (AUC 0.88, sensitivity 91.7%, specificity 70.5%), NCPV ≥ 1737 mm3 (AUC 0.71, sensitivity 75.0%, specificity 72.6%), LAPV ≥ 358 mm³ (AUC 0.71, sensitivity 91.7%, specificity 52.7%), and MCPA ≥ 4.51 mm² (AUC 0.9, sensitivity 91.7%, specificity 84.0%) were the best cutoff value for predicting CNs. Therefore, CCTA is useful for predicting OCT-detected CNs.
Real-world clinicopathological outcome of bronchopulmonary carcinoids with lymph node metastasis received radical surgery：A single-centre retrospective study in the last 22 Years in China
Authors: Gao Chao , Zhang Jiaqi , Wang Yadong , Huang Cheng , Zhang Ye , Chen Yeye , Li Shanqing 
Published: August 2022

Abstract
Background: Bronchopulmonary carcinoids(BPCs) are rare malignancies but are known to be one of the most common causes of the ectopic adrenocorticotropic hormone(ACTH) syndrome. Surgery is the mainstay of therapy and one key question considering surgical treatment is the impact of local lymph node metastases. We sought to determine the risk factors and prognosis of LN metastases in resected carcinoid patients.Methods: Data of 42 patients of BPCs with lymph node metastasis who received radical surgery in Peking Union Medical College Hospital(PUMCH) from Jan 2000 to Dec 2021were retrospectively analysed. Overall survival (OS) and progression-free survival(PFS) were analyzed using Kaplan-Meier curves. Independent prognostic factors were assessed by COX hazard proportion model. Results: It was indicated that in patients received radical surgery with local lymph node positive of BPCs, the 5-year OS and PFS rate was 74.5%, 68.3%, respectively. Multivariate Cox regression indicated that ectopic ACTH syndrome(EAS) could predict significantly to a better OS and PFS. In the subgroup analysis, the age, tumor size, Ki-67 index, histology and postoperative chemotherapy in patients with EAS had significantly differences with those without EAS. Conclusions: Our study certified R0 resection with lymphadenectomy was effective in patients with lymph nodal positive. The ectopic ACTH syndrome was a protective factor for a better prognosis, which could provide clear evidence for operations.
Patient Questionnaires Based Parkinson’s Disease
Classification Using Artificial Neural Network
Authors: Das Tarakashar , Mobassirin Sabrina , Hossain Syed Mohammod Minhaz , Das Aka , Sen Anik , K Khaleque Md. Aashiq , Deb Kaushik 
Published: August 2022

Abstract
Parkinson’s disease is one of the most prevalent and harmful neurodegenerative conditions (PD). Even today, PD diagnosis and monitoring remain pricy and inconvenient processes. With the unprecedented progress of artificial intelligence algorithms, there is an opportunity to develop a cost-effective system for diagnosing PD at an earlier stage. There is no permanent remedy established yet; however, an earlier diagnosis helps to lead a better life. The three most responsible symptoms of Parkinson’s Disease are tremors, rigidity, and body bradykinesia. Therefore, to diagnose PD patients at the beginning stage, we investigate the 53 unique features of Parkinson’s Progression Markers Initia-
tive (PPMI) dataset. Furthermore, we utilize Machine Learning (ML), Ensemble Learning (EL), and Artificial Neural Network (ANN) for classification. As feature selection is an integral part in developing generalize model, we investigate including and excluding feature selection. Four feature selection methods are incorporated - Low Variance Filter, Wilcoxon rank-sum test, Principle Component Analysis, and Chi-Square test. Our proposed ANN model attains the best mean accuracy of 99.51%, 98.17% mean specificity, 0.9830 mean Kappa Score, 0.99 mean AUC, and 99.70% mean F1-score. The efficiency of our suggested technique on diverse data modalities is demonstrated by comparison
with recent publications. Finally, we established a trade-off between classification time and accuracy
A point cloud-based welding trajectory planning method for plane welds
Authors: Zhang Yuankai , Jiang Yong , Tian Xincheng , Xu Xiaolong , Geng Yusen , Lai Min 
Published: August 2022

Abstract
Plane welds are a common type of weld in industrial sites. When the welding robot welds multiple types of plane welds at the same time, the traditional teaching and programming modes become relatively complicated. Therefore, in order to solve the problem of automatic robot welding of various types of plane welds, taking plane V-type butt, plane I-type butt, and plane lap welds as examples, this paper proposes a plane weld extraction method based on 3D vision. Firstly, in order to realize the line and plane segmentation of the workpiece point cloud, we establish the concept of plane point cloud density. Secondly, to segment workpiece edge lines, an iterative segmentation algorithm based on RANSAC is proposed. Then, based on the geometric features of the workpiece, a method for extracting weld feature points based on centroid positioning is proposed. Finally, the least squares method is used to fit the feature points of the welding seam to complete the welding trajectory planning. The experimental results show that the method can well solve the problem of automatic planning welding trajectory of plane V-type butt, plane I-type butt, and plane lap welds, to realize that the welding robot can simultaneously weld various plane welds without teaching and programming.
The use of condoms and other birth control methods among sexually active school-going adolescents in nine sub-Saharan African countries
Authors: James Peter Bai , Osborne Augustus , Babawo Lawrence Sao , Bah Abdulai Jawo , Margao Emmanuel Kamanda 
Published: August 2022

Abstract
Background: Adolescents in sub-Saharan Africa still face sexual and reproductive health challenges. Contraceptives have been used to address these challenges. However, contraceptive uptake among young people in Africa remains a challenge despite efforts at national and global levels. We estimated the prevalence and correlates of condom use and other birth control methods among sexually active school-going adolescents in nine sub-Saharan African (SSA) countries.Methods: We conducted a secondary analysis of the Global School-based Student Health Surveys (GSHS) datasets pooled from nine SSA countries. We included a sample of 27504 school-going adolescents aged 11 and 18 years. We employed meta-analysis using a random-effects model to estimate the total prevalence of the use of condoms, other birth control methods other than a condom and any birth control method at last sexual intercourse. We conducted complex sample descriptive and logistic regression analyses.Results: More than half [n=4430, 53.8% (43.9- 63.8)], two-fifth [n=3242, 39.5% (33.2-45.9) and two-thirds of adolescents [n=4838, 65.6% (57.5-73.7)] of sexually active in school adolescents across the nine sub-Saharan African countries used condom, other birth control methods and any form birth control method during their last sexual intercourse, respectively. The non-use of condoms at last sex was associated with being younger (less than 16 years) [AOR=1.48;95%CI: 1.12-1.94], early sexual debut [AOR=1.81(1.47-2.22)], having two or more sexual partners [AOR=1.30(1.06-1.58)] and no/minimal parental support [AOR=1.54(1.17-2.03)]. The non-use of other birth control methods at last sex was associated with being male [AOR=1.37 (1.09- 1.73)], early sexual debut [AOR=1.83(1.48-2.27) and no/minimal parental support [AOR=1.64(1.34-2.00)].Conclusion: Contraceptive need among sexually active school adolescents in the nine sub-Saharan African countries is high. Such a need calls for the development of country-specific and or the review of existing school-based sexual health education and youth-friendly sexual and reproductive health interventions that target risky adolescents and promote adolescent-parent effective communication, connectedness and support.
River plastic during floods: Amplified mobilization, limited river-scale dispersion
Authors: Emmerik Tim van , Frings Roy , Schreyers Louise , Hauk Rahel , de Lange Sjoukje , Mellink Yvette 
Published: August 2022

Abstract
Plastic pollution in the world's rivers and ocean is increasingly threatening ecosystem health and human livelihood. In contrast to what is commonly assumed, most mismanaged plastic waste that enters the environment is not exported into the ocean. Rivers are therefore not only conduits, but also reservoirs of plastic pollution. Plastic mobilization, transport and retention dynamics are influenced by hydrological processes, and river catchment features (e.g. land-use, vegetation, and river morphology). Increased river discharge has been associated with elevated plastic transport rates, although the exact relation between the two can vary over time and space. The precise role of an extreme discharge event on plastic transport is however still unknown. Here, we show that fluvial floods drive plastic transport and accumulation in river systems. We collected unique observational evidence during the July 2021 flood along the complete Dutch part of the Meuse. Plastic transport multiplied with a factor of 141 upstream of the Dutch Meuse, compared to non-flood conditions, making the Meuse one of the most polluted rivers measured to date. Over one-third of the annual plastic transport was estimated to occur within the six-day period of extreme discharge. Towards the river mouth, plastic transport during the flood period decreased by 90\%, suggesting that the dispersal of plastic mobilized during the flood is limited due to the entrapment on riverbanks, in vegetation, and on the floodplains. Plastic accumulation on the riverbanks decreased significantly along the river, corroborating the river's function as plastic reservoir. Using new observational evidence, we demonstrate the crucial role of floods as driver of plastic transport and accumulation in river systems. Floods amplify the mobilization of plastics, but the effects are local, and the river-scale dispersion is limited. We anticipate that our findings serve as a starting point for improving global estimates of river plastic transport, retention, and export into the sea. Moreover, our results provide essential insights for future large-scale and long-term quantitative assessments of river plastic pollution. Reliable observations and a fundamental understanding of plastic transport are key to designing effective prevention and reduction strategies.
Blocking Cx43 alleviates P2X4 receptor-mediated neuropathic pain in CCI rats
Authors: Xing Juping , Wang Hongji , Chen Lisha , Wang Hanxi , Huang Huan , Huang Jiabao , Xu Changshui 
Published: August 2022

Abstract
Neuropathic pain is a growing concern in the medical community, and the search for new analgesic targets for neuropathic pain has become a new hot spot. In this study, we examined whether Cx43 has a key role in neuropathic pain mediated by P2X4 receptor- in rats after peripheral nerve injuring. Our experimental results show that ATP released via Cx43 has a crucial role in P2X4 receptor-mediated neuropathic pain in the rat model of chronic constriction injury (CCI) of the sciatic nerve, and the p38, ERK, and NF-kB signaling pathways have been shown to be involved in the development of neuropathic pain processes. In brief, blockade of CX43 could attenuateP2X4 receptor-mediated neuropathic pain in rats suffering from CCI, and Cx43 may be promising therapeutic targets for the development of novel pharmacological agents in the management of neuropathic pain.
Human placental extracts suppress mast cell activation and induce mast cell apoptosis
Authors: Wu Tongqian , He Jingjing , Yan Shirong , Li Jing , Chen Ke , Zhang Dingshan , Cheng Mingliang , Xiang Zou , Yu Fang 
Published: August 2022

Abstract
Background
Human placental extracts (HPE) have been documented to facilitate the healing of certain disorders including allergy. However, the effects of HPE on the functionality of mast cells, a critical cell type in allergic diseases, have not been reported.
Methods
To investigate the effects of HPE on the regulation of allergy with respect to the biological functions of mast cells, the mast cell line C57 cells were treated with HPE followed by the assessment of cell proliferation, apoptosis, activation, chemotaxis and phagocytosis. Mouse peritoneal mast cells were also investigated for their responses to induction of apoptosis by HPE in vivo. Furthermore, the effect of HPE on mast cell degranulation was confirmed using the passive cutaneous anaphylaxis (PCA) assay, an acute allergy model.
Results
HPE was capable of suppressing mast cell proliferation and inducing mast cell apoptosis. Mast cell degranulation in response to compound 48/80- or anti-DNP IgE and DNP-mediated activation was suppressed. In addition, treatment with HPE compromised the production of cytokines by mast cells and cell chemotaxis. These observations were consistent with the dampened passive cutaneous anaphylaxis (PCA) assay following treatment with HPE.
Conclusion
This study revealed a suppressive effect of HPE on overall mast cell activities, suggesting a potential regulatory role of HPE on the alleviation of allergic diseases through mast cells.
An improved real time detection of data poisoning attacks in Deep Learning Vision systems
Authors: Raghavan Vijay , Mazzuchi Thomas , Sarkani Shahram 
Published: August 2022

Abstract
The practice of using deep learning methods in safety critical vision systems such as autonomous driving has come a long way. As vision systems supported by deep learning methods become ubiquitous, the possible security threats faced by these systems have come into greater focus. As it is with any artificial intelligence system, these deep neural vision networks are first trained on a data set of interest, once they start performing well, they are deployed to a real-world environment. In the training stage, deep learning systems are susceptible to data poisoning attacks. While deep neural networks have proved to be versatile in solving a host of challenges. These systems have complex data ecosystems especially in computer vision. In practice, the security threats when training these systems are often ignored while deploying these models in the real world. However, these threats pose significant risks to the overall reliability of the system. In this paper, we present the fundamentals of data poisoning attacks when training deep learning vision systems and discuss countermeasures against these types of attacks. In addition, we simulate the risk posed by a real-world data poisoning attack on a deep learning vision system and present a novel algorithm MOVCE - Model verification with Convolutional Neural Network and Word Embeddings which provides an effective countermeasure for maintaining the reliability of the system. The countermeasure described in this paper can be used on a wide variety of use cases where the risks posed by poisoning the training data are similar.
A diatom-inferred water depth transfer function from a single lake in the northern California Coast Range
Authors: Han Jiwoo , Kirby Matthew , Carlin Joe , Nauman Benjamin , MacDonald Glen 
Published: August 2022

Abstract
This study examines the relationship between diatom assemblages from lake sediment surface samples and water depth at Kelly Lake, California. A total of 40 surface sediment samples (top 5 cm) were taken at various depths within the small (3.4 ha) five-meter-deep lake. Secchi depths, water temperature, pH, salinity, conductivity, and total dissolved solids were also measured. Some diatom species showed distinct association with depth (e.g., Fragilaria crotonensis, Nitzschia semirobusta). The relationship between the complete diatom assemblages and water depth was analyzed and assessed by depth-constrained cluster analysis, a one-way analysis of similarity, and principal components analysis. Statistically significant differences were found between the assemblages associated with shallow depth (0 m – 1.25 m), mid-depth (1.25 m – 3.75 m), and deep depth (3.75 m – 5.2 m) locations. The relationship between diatom assemblages and lake depth allowed two transfer models to be developed using the Modern Analogue Technique (MAT) and Weighted Averaging Partial Least Squares (WA-PLS). These models were compared and assessed by residual scatter plots. We demonstrate that the diatom assemblages in the sediments of Kelly Lake are differentiated by lake depth. The results indicate that diatom-inferred transfer models based on surface sediment samples from a single lake can be a useful tool for studying past hydroclimatic variability (e.g. lake depth) from cores taken from such lakes in California.
THE IMPACT: Education Level Has a Relativity for The Recovery of Total Knee Arthroplasty: a meta-analysis of randomized controlled trials
Authors: Zhou Yuanyuan , Zhang Bokai , Ran Tianfei , Ke Song , Qin Yinyin , Zhang Yuan , Wang Min , Xu Yuan 
Published: August 2022

Abstract
Objective: This study aimed to observe the relationship between education level and outcomes after total knee arthroplasty (TKA).Methods: 1264 patients after TKA in our hospital from April 2016 to April 2020 were reviewed. These patients were divided into 4 groups (A who are illiterate, B who had elementary school degree, C who had junior high school degree, D who had senior high school degree or higher) by the educational level, which was blinded to the observers. The postoperative outcomes of KSS score, pain, joint extension and flexion function were observed 1 month, 6 months and 1 year after discharged from hospital.Results: Among 1253 patients met the inclusion criteria, the average age was 68.63 years, the average weight was 57.73 kg. There are no distinctions among 4 groups one day after the surgery. However, the outcomes of the follow up were that, the KSS score was: 77.84 ± 10.635; 80.70 ± 8.956; 87.92 ± 8.123;91.27 ± 8.262, with significant differences (P < 0.05). The mean VAS scores were: 1.97 ± 1.60; 2.07 ± 1.66; 1.197 ± 1.5265, 1.044 ± 1.4662. Patients in Group C and D had significantly less pain than that in Group A and B (P < 0.05). The knee flexion range of motion (ROM) was: 91.21 ± 11.69 °; 91.77 ± 11.95 °; 102.12 ± 11.38 °; 109.96 ± 10.64 °, Group D performed best, with significant differences (P < 0.05). The knee extension ROM were: – 2.41 ± 4.49 °; – 0.91 ± 2.82 °; – 0.83 ± 2.87 °; – 0.35 ± 1.60 °, with significant difference between Group D and the others (P < 0.05).Conclusion: Education level is an important factor affecting the outcomes after total knee arthroplasty. The patients with higher education level would likely have better outcomes.
Novel Xylose and Shikimate Transporters Facilitating the Design of a Microbial Consortium as a Chassis for Benzylisoquinoline Alkaloid Production
Authors: Gao Meirong , Zhao Yuxin , Su Qianhe , Shao Zengyi 
Published: August 2022

Abstract
Plant-sourced aromatic amino acid (AAA) derivatives are a vast group of compounds with broad applications. This study focuses on the development of a yeast consortium for efficient production of (S)-norcoclaurine, the key precursor for benzylisoquinoline alkaloid biosynthesis. A novel xylose-specific transporter insensitive to glucose inhibition enabled the concurrent mixed-sugar utilization in Scheffersomyces stipitis, which played a crucial role in enhancing the flux entering the highly regulated shikimate pathway located upstream of AAA biosynthesis. Two novel quinate permeases isolated from Aspergillus niger facilitated shikimate translocation to the co-cultured Saccharomyces cerevisiae that converted shikimate to (S)-norcoclaurine, resulting in the highest titer (4.2 mg/L) ever reported in literature, nearly 40-fold higher than the best titer from an S. cerevisiae monoculture. Our findings magnify the potential of microbial consortium platforms for the economical de novo synthesis of complex compounds, where pathway modularization and compartmentalization in distinct specialty strains enable effective fine-tuning of long biosynthetic pathways and diminish intermediate buildup, thereby leading to remarkable increases in production.
A post-quantum signature scheme from the secant variety of the Grassmannian
Authors: Tullio Daniele Di , Gyawali Manoj 
Published: August 2022

Abstract
In this paper we present a new signature scheme based on the difficulty of finding a point in a shifted Grassmannian variety or on its secant variety from a knowledge of its defining polynomials. An advantage of using the secant variety of the Grassmannian is that it is defined by sparse cubic equations, which are in general more difficult to solve than quadratic ones, thereby reducing the size of the public key.
Recurrence and prognosticators of recurrence in odontogenic keratocyst of the jaws.
Authors: BERA RATHINDRA , TANDON SAPNA , TIWARI PREETI 
Published: August 2022

Abstract
Introduction: The incidence of recurrence of OKC varied from 2.5%-62%. Studies have linked recurrence to treatment methods and also clinical and pathological features. The aim of this study was to evaluate the 5 year recurrence and the factors associated with recurrence in odontogenic keratocysts of the jaws.Methods: A retrospective review of records was done from the Institute’s Medical Records Directory from 2010-2021. The following data were obtained of the lesion; age at presentation, gender, site, subsite, radiographic presentation (locularity), radiographic borders, presence or absence of satellite cysts, inflammatory infiltrate, and treatment rendered presence or absence of cortical perforation and soft tissue extension and presence or absence of recurrence. Kaplan Meir estimator was used to evaluate recurrence rate and log rank test was used to compare the survival amongst groups. Cox regression analysis was used to evaluate the odds ratio to find out the possible factors influencing risk of recurrence. A p value of <0.05 was considered statistically significant at 95% confidence interval. Results: In our study cohort 44.44% had recurrence. Multilocular lesions, lesions with scalloped borders, presence of soft tissue extension and cortical perforation, presence of satellite cysts and inflammatory infiltrate and enucleation with peripheral ostectomy were significantly associated with recurrence. However; soft tissue extension, cortical perforation, enucleation with peripheral ostectomy and marsupialization followed by enucleation+ peripheral ostectomy were independent risk factors. Conclusion: There is still debate on the best treatment modality for the management of OKCs. More studies are required to quantify the results.