bluuebunny/crossref_metadata_2025_split huggingface dataset:
Failure is not an option: Entrepreneurship and the existential crisis of internationalization in the U.S.
Authors: Glass Chris R. , Cruz Natalie I. 
Published: May 2022

AbstractInternationalization has become intertwined with efforts for institutions to compensate for declines in public funding with the development of new revenue streams. The purpose of this study is to understand the social construction of entrepreneurship in internationalization in the United States as well as explore the multiple meanings of entrepreneurship and its contradictions in discourse among senior international officers. The findings discuss and explore competing views, tensions and ethical complexities of the ‘new entrepreneurism’ increasingly common in internationalization, which blends creative problem‐solving with pressures for revenue generation. The findings of this study illustrate that as the world faces genuine existential crises that threaten the continued existence of our species on the planet, internationalization is in the midst of an identity crisis. The drift towards privatization is proving to be increasingly unsustainable and an entirely insufficient response to the existential threats that face the world.
Searched and found? The association between use of health information sources and success in getting the desired information
Authors: Rosenberg Dennis 
Published: May 2022

AbstractBackgroundAlthough many health information seeking studies are concerned with longer range outcomes (e.g. patient‐provider communication) the immediate outcomes for the searchers are whether they found the desired information, for whom and how successfully.ObjectivesTo examine the association between health information seeking via various sources and the reported extent of success in getting the desired information the information needs perspective.MethodsData were obtained from the 2017 Israel Social Survey and analysed using multinomial regression models. The sample included individuals who reported engaging in seeking health information prior to the survey and mentioned the extent of success in obtaining the desired health information (fully, partially, or not‐at‐all) (N = 2197). Multinominal regression technique served for the multivariable analysis.DiscussionEngagement in health information seeking via friends, family and using various websites (excluding those by Ministry of Health and Health Funds) was associated with the increased likelihood of partial success in getting the desired information. Education level and population group, affected level of success.ConclusionsThe (partial) success in meeting health consumers' information needs is associated with the turn to particular sources. Public health professionals and health provider institutions should improve provision and delivery of health information to meet consumer health information needs.
The cGMP‐dependent protein kinase gene can regulate trail‐following behaviour and locomotion in the termite Reticulitermes chinensis Snyder
Authors: Xu Huan , Yu Yichun , Gao Yongyong , Hassan Ali , Jia Bao , Huang Qiuying 
Published: May 2022

AbstractSocial behaviours in termites are closely related to the chemical communication between individuals. It is well known that foraging worker termites can use trail pheromones to orient and locomote along trails so as to take food resources back to the nest. However, it is still unclear how termites recognize trail pheromones. Here, we cloned and sequenced the cGMP‐dependent protein kinase (PKG) gene from the termite Reticulitermes chinensis Snyder, and then examined the response of termites to trail pheromones after silencing PKG through RNA interference. We found that PKG knockdown impaired termite ability to follow trail pheromones accurately and exhibited irregular behavioural trajectories in response to the trail pheromone in the termite R. chinensis. Our locomotion assays further showed that PKG knockdown significantly increased the turn angle and angular velocity in the termite R. chinensis. These findings help us better understanding the molecular regulatory mechanism of foraging communications in termites.
Analysis of circRNA‐mRNA expression profiles and functional enrichment in diabetes mellitus based on high throughput sequencing
Authors: Zhao Wanni , Meng Xue , Liang Jianfeng 
Published: May 2022

AbstractTo study the pathogenesis of diabetes mellitus (DM) and identify new biomarkers, high‐throughput RNA sequencing provides a technical means to explore the regulatory network of MD gene expression. To better elucidate the genetic basis of DM, we analysed the circRNA and mRNA expression profiles in serum samples from diabetic patients. The circRNAs and mRNAs with abnormal expression in the DM group and non‐diabetic group (NDM) were classified by RNA sequencing and differential expression analysis. The circRNA‐miRNA‐mRNA regulatory network reveals the mechanism by which competitive endogenous RNAs (ceRNAs) regulate gene expression. The biological functions and interactions of circRNA and mRNA were analysed by gene ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Differential expression analysis showed that 441 circRNAs (366 up‐regulated, 75 down‐regulated) and 683 mRNAs (354 up‐regulated, 329 down‐regulated) were significantly differentially expressed in the DM group compared with the NDM group. Screening of the differential genes at the nodes of the interaction network showed that a single circRNA could interact with multiple miRNAs and then jointly regulate more mRNAs. In addition, the expressions of circRNA CNOT6 and AXIN1 as well as mRNA STAT3, MYD88, and B2M were associated with the progression of diabetes. Enrichment pathway analysis indicated that differentially expressed circRNA and mRNA may participate in Nod‐like receptor signalling pathway, insulin signalling pathway, sphinolipid metabolism pathway, and ribosome pathway, and play a role in the pathogenesis of diabetes. This study provides a theoretical basis for elucidating the molecular mechanism of DM occurrence and development at circRNA and mRNA levels.
Endogenous hormones improve the salt tolerance of maize (Zea mays L.) by inducing root architecture and ion balance optimizations
Authors: Hu Dan‐dan , Dong Shuting , Zhang Jiwang , Zhao Bin , Ren Baizhao , Liu Peng 
Published: May 2022

AbstractThe growth and development of maize is affected in a crucial way by the salinity of the soil it grows in. Therefore, if we want to improve the salt tolerance of maize, it is of paramount importance to understand how it responds to salt stress. To explore how maize adapts to a saline environment, we chose one salt‐tolerant maize variety, Jingnongyu 658 (JNY658), and one salt‐sensitive variety, Yunyu7 (YY7), and treated the seedlings of both varieties with a 100 mM NaCl solution. After harvesting them, we analysed the adaptive responses to salt stress with respect to various characteristics of the root architecture and water and nutrient acquisition. We found that when subjected to salt stress, both varieties exhibited a reduction in biomass, root activity, 15N and H218O uptake amount, lateral root branching density, lateral root length, total root length, root surface area and root volume, where the YY7 suffered a greater reduction than the JNY658. Salt stress also induced a decreased absorption of K+, passively promoted the absorption of Na+ and gave rise to an increased Na+/K+ ratio in the roots of both varieties. It should be noted that JNY658 exposed to salt stress developed a lower Na+/K+ ratio than YY7. Compared with the control group, the expression of ZmSOS1, ZmSOS2 and ZmNHX genes in the roots of JNY658 subjected to salt stress was significantly upregulated, which enabled them to maintain a lower Na+ content. In both varieties, the salicylic acid (SA) and gibberellin19 acid (GA19) content increased significantly, but the auxin (IAA), jasmonic acid (JA) and trans‐zeatin (TZ) content was reduced. In addition, JNY658 in salt stress significantly increased their abscisic acid (ABA) content, due to the increased expression of its key biosynthesis genes, NCED. Compared with JNY658, the reductions in IAA, JA and TZ content in YY7 were greater, while the increases in ABA and SA content were smaller. The varieties in the ABA, JA, SA and IAA of roots subjected to salt stress significantly or extremely significantly correlated with the lateral root branching density, lateral root length, root surface area, Na+ content, K+ content and Na+/K+ ratio. We conclude that the salt‐tolerant maize variety mitigated the toxic effect of salinity on maize root growth and development by regulating the hormone content and enhancing its expression of stress‐responsive genes while maintaining ion homeostasis and promoting water and nutrient acquisition, which ultimately resulted in a less pronounced decrease in plant biomass.
Comparison of methodological approaches to the study of young sex chromosomes: A case study in Poecilia
Authors: Darolti Iulia , Almeida Pedro , Wright Alison E. , Mank Judith E. 
Published: May 2022

AbstractStudies of sex chromosome systems at early stages of divergence are key to understanding the initial process and underlying causes of recombination suppression. However, identifying signatures of divergence in homomorphic sex chromosomes can be challenging due to high levels of sequence similarity between the X and the Y. Variations in methodological precision and underlying data can make all the difference between detecting subtle divergence patterns or missing them entirely. Recent efforts to test for X‐Y sequence differentiation in the guppy have led to contradictory results. Here, we apply different analytical methodologies to the same data set to test for the accuracy of different approaches in identifying patterns of sex chromosome divergence in the guppy. Our comparative analysis reveals that the most substantial source of variation in the results of the different analyses lies in the reference genome used. Analyses using custom‐made genome assemblies for the focal population or species successfully recover a signal of divergence across different methodological approaches. By contrast, using the distantly related Xiphophorus reference genome results in variable patterns, due to both sequence evolution and structural variations on the sex chromosomes between the guppy and Xiphophorus. Changes in mapping and filtering parameters can additionally introduce noise and obscure the signal. Our results illustrate how analytical differences can alter perceived results and we highlight best practices for the study of nascent sex chromosomes.
The crown lengthening double guide and the digital Perio analysis
Authors: Coachman Christian , Valavanis Konstantinos , Silveira Fernanda Camargo , Kahn Sergio , Tavares Alexandra Dias , Mahn Eduardo , Parize Hian , Saliba Felipe Miguel P. 
Published: May 2022

AbstractObjectiveThis article describes a surgical crown lengthening double guide, which was digitally obtained to improve diagnosis, treatment outcome, and follow‐up.Clinical considerationsThe rehabilitation of anterior dental esthetics should involve interdisciplinary and facially driven planning for achieving pleasant long‐term outcomes. Surgical crown lengthening is one of the most common periodontal surgery, which can be assisted by digital tools to improve surgical planning and follow‐up.ConclusionThe double guide for surgical crown lengthening allows the proper management of hard and soft tissues for achieving a predefined goal based on biological requirements and facially driven planning. In addition, the digital quality control allows the follow‐up compared with the pre‐operative condition and planned treatment plan.Clinical significanceThe use of digital tools allow the clinician to develop a facially driven planning with proper communication with the team and patient, leading to a shorter, more predictable, and less invasive surgical technique, reducing postoperative inflammation and increasing patient comfort.
Flood impact on income inequality in the Itapocu River basin, Brazil
Authors: Silva Araújo Rafael , Ohara Miho , Miyamoto Mamoru , Takeuchi Kuniyoshi 
Published: May 2022

AbstractDisasters worldwide tend to affect the poorest more severely and increase inequality. Brazil is one of the countries with high income‐inequality rates and has unplanned urbanization issues and an extensive disaster risk profile with little knowledge on how those disasters affect people's welfare. Thus, disasters often hit the poorest hardest, increasing the country's income inequality and poverty rates. This study proposes a method to assess the impact of floods on households spatially based on their income levels by conducting flood analysis and income analysis. The method is applied to the Itapocu River basin (IRB) located in Santa Catarina State, Brazil. The flood is assessed by conducting rainfall analysis and hydrological simulation and generating flood inundation maps. The income is evaluated using downloaded 2010 census data and a dasymetric approach. Flood and income information is combined to analyze flood‐impacted households by income level and flood return period. The results confirm the initial assumption that flood events in the IRB are more likely to affect the lowest‐income households rather than the highest‐income levels, thus, increasing the income inequality.
Expanding Opioid Use Disorder Treatment in Priority Areas: The Role of Certified Nurse‐Midwives
Authors: Kane Claire , Topmiller Michael 
Published: May 2022

IntroductionPerinatal opioid use disorder (OUD) is associated with maternal and neonatal morbidity, and treatment has been definitively shown to improve outcomes for both. As of 2018, certified nurse‐midwives (CNMs) can prescribe buprenorphine for the treatment of OUD by obtaining a Drug Addiction Treatment Act waiver. This research aims to identify the number of CNMs who are waivered to prescribe buprenorphine for the treatment of OUD and who practice in priority areas for treatment expansion.MethodsThrough a descriptive study design, authors collected and analyzed publicly available data from August 2020 to January 2021. Using the software GeoDa, authors identified priority counties in the United States and the number of waivered and nonwaivered CNMs in these areas. Counties were designated as priority if they had drug‐poisoning mortality rates in the top 20th percentile of all US counties and no health care providers waivered to treat OUD or had a waivered health care provider per population rate in the bottom 20th percentile.ResultsAnalysis identified 141 priority counties in 23 states concentrated in rural areas throughout the Appalachian region of the United States. Tennessee had the most priority counties of any state. As of 2020, only 26 CNMs in the United States were waivered to prescribe buprenorphine, none of whom practiced in priority counties. Of the CNMs practicing in priority counties and without waivers, 59% (39 of 66) practiced in states where CNMs have independent practice authority.DiscussionCNMs are uniquely positioned to treat perinatal OUD given their scope of practice as primary and reproductive health care providers, especially in rural, underserved areas. To increase the number of midwives prescribing buprenorphine and expand treatment access, researchers, educators, practice leaders, and policy makers must address barriers to and experiences of treating OUD.
Assessing deterioration using impairment and functional outcome measures in chronic inflammatory demyelinating polyneuropathy: A post‐hoc analysis of the immunoglobulin overtreatment in CIDP trial
Authors: van Veen Robin , Wieske Luuk , Lucke Ilse , Adrichem Max E. , Merkies Ingemar S. J. , van Schaik Ivo N. , Eftimov Filip 
Published: May 2022

AbstractIt is unclear whether frequently used cutoff values for outcome measures defining minimal clinically important differences (MCIDs) can accurately identify meaningful deterioration in chronic inflammatory demyelinating polyneuropathy (CIDP). We used data from the immunoglobulin overtreatment in CIDP (IOC) trial, in which 60 clinically stable patients with CIDP were randomized to intravenous immunoglobulin (IVIg) withdrawal or continuation. We calculated change scores of the Inflammatory Rasch‐Built Overall Disability Scale (I‐RODS), grip strength, and Medical Research Council‐sum score (MRC‐SS) and classified visits based on a treatment anchor (ie, decision to restart/increase treatment after reaching a predefined early endpoint of deterioration). The variability of scores in patients without deterioration was calculated using the limits of agreement. We defined optimized MCIDs for deterioration and specific combinations of MCIDs from different outcome measures, and subsequently calculated the accuracies of the (combined) MCIDs. Substantial variability was found in scores of the I‐RODS, grip strength and MRC‐SS in patients without deterioration over time, and most MCIDs were within the limits of the variability observed in patients without deterioration. Some MCID cut‐offs were insensitive but highly specific for detecting deterioration, for example, the MCID‐SE of −1.96 of the I‐RODS and −2 point on the MRC‐SS. Others were sensitive, but less specific, for example, −4 centiles of the I‐RODS. Some combined MCIDs resulted in high specificities and moderate sensitivities. Our results suggest that clinically important deterioration cannot be distinguished from variability over time with currently used MCIDs on the individual level. Combinations of MCIDs might improve the accuracy of determining deterioration, but this needs validation.
Clinical study of auricular point seed burying combined with fire dragon pot moxibustion in perimenopausal women with insomnia
Authors: Feng Huan , Pan Aihong , Zheng Guohua , Yu Weihua 
Published: May 2022

AbstractObjectiveTo intervene the insomnia symptoms of perimenopausal women by auricular point seed burying combined with fire dragon pot moxibustion, in order to improve the quality of sleep and life of the participants.MethodsSeventy female participants with perimenopausal insomnia who were treated with Chinese medicine techniques from January 2020 to October 2020 were randomly divided into a control group and an observation group, with 35 participants in each group. Participants in the control group were treated with the traditional Chinese medicine nursing intervention of burying seeds at auricular points. And participants in the observation group were additionally treated with fire dragon pot moxibustion. After 10 weeks of intervention, the Pittsburgh Sleepiness Index (PSQI), self‐assessment scores of anxiety (SAS) and depression (SDS), and treatment efficacy of the two groups were compared, respectively.ResultsBefore the intervention, there was no statistically significant difference in general information, sleep index scores, SAS, SDS scores between the two groups (p > 0.05). After the intervention, the SAS, SDS, and PSQI scores were significantly lower than the control group. Compared with the control group, the time to fall asleep was shorter and the duration of total sleep was longer in the observation group (p < 0.05). The treatment efficacy was better in the observation group (p < 0.05).ConclusionAuricular point seed burying combined with fire dragon pot moxibustion therapy can be more effect than auricular point seed burying alone in treating perimenopausal women with insomnia.
Sleep, insomnia and mental health
Authors: Palagini Laura , Hertenstein Elisabeth , Riemann Dieter , Nissen Christoph 
Published: May 2022

SummaryWhile sleep serves important regulatory functions for mental health, sleep disturbances, in particular insomnia, may favour a state of allostatic overload impairing brain neuroplasticity and stress immune pathways, hence contributing to mental disorders. In this framework, the aim of this work was to link current understanding about insomnia mechanisms with current knowledge about mental health dysregulatory mechanisms. The focus of the present work was on mood, anxiety, and psychotic disorders, which represent important challenges in clinical practice. Literature searches were conducted on clinical, neurobiological, and therapeutic implications for insomnia comorbid with these mental disorders. Given the complexity and heterogeneity of the existing literature, we ended up with a narrative review. Insomnia may play an important role as a risk factor, a comorbid condition and transdiagnostic symptom for many mental disorders including mood/anxiety disorders and schizophrenia. Insomnia may also play a role as a marker of disrupted neuroplasticity contributing to dysregulation of different neurobiological mechanisms involved in these different mental conditions. In this framework, insomnia treatment may not only foster normal sleep processes but also the stress system, neuroinflammation and brain plasticity. Insomnia treatment may play an important preventive and neuroprotective role with cognitive behavioural therapy for insomnia being the treatment with important new evidence of efficacy for insomnia, psychopathology, and indices of disrupted neuroplasticity. On the other hand, pharmacological pathways for insomnia treatment in these mental conditions are still not well defined. Therapeutic options acting on melatonergic systems and new therapeutic options acting on orexinergic systems may represents interesting pathways of interventions that may open new windows on insomnia treatment in mental disorders.
Inter‐ and intra‐observer variability in the selection of therapy for infantile hemangiomas among pediatric dermatologists in Spain
Authors: Colmenero María , del Boz Javier , Bernabeu Wittel José , Roé Esther , Feito‐Rodríguez Marta , Vicente‐Villa María Asunción , Martín‐Santiago Ana , Palencia Pérez Sara Isabel , Azon Antoni , Valdivielso‐Ramos Marta , Torrelo Antonio , Sánchez Moya Ana Isabel , Campos‐Domínguez Minia , Garnacho‐Saucedo Gloria , Azaña Defez José Manuel , Vera Casaño Ángel , Tercedor‐Sánchez Jesús , Alcalá Rebeca , González‐Enseyat María Antonia , Giacaman Aniza , Hernández‐Martin Ángela , Monserrat García María Teresa , Bauzá Ana , Domínguez‐Cruz Javier , García‐Doval Ignacio , Grau‐Pérez Mercè 
Published: May 2022

AbstractBackgroundGuidelines and expert recommendations on infantile hemangiomas (IH) are aimed at increasing homogeneity in clinical decisions based on the risk of sequelae.ObjectiveThe objective was to analyze the inter‐ and intra‐observer agreement among pediatric dermatologists in the choice of treatment for IH.MethodsWe performed a cross‐sectional inter‐rater and intra‐rater agreement study within the Spanish infantile hemangioma registry. Twenty‐seven pediatric dermatologists were invited to participate in a survey with 50 clinical vignettes randomly selected within the registry. Each vignette contained a picture of an infantile hemangioma with a clinical description. Raters chose therapy among observation, topical timolol, or oral propranolol. The same survey reordered was completed 1 month later to assess intra‐rater agreement. Vignettes were stratified into hemangioma risk categories following the Spanish consensus on IH. The agreement was measured using kappa statistics appropriate for the type of data (Gwet's AC1 coefficient and Gwet's paired t test).ResultsTwenty‐four dermatologists completed the survey. Vignettes represented 7.8% of the Spanish hemangioma registry. The inter‐rater agreement on the treatment decision was fair (AC1 = 0.39, 95% confidence interval [CI]: 0.30–0.47). When stratified by risk category, good agreement was reached for high‐risk hemangiomas (AC1 = 0.77, 95% CI: 0.51–1.00), whereas for intermediate‐ and low‐risk categories, the agreement was only fair (AC1 0.31, 95% CI: 0.16–0.46 and AC1 = 0.38, 95% CI: 0.27–0.48, respectively). Propranolol was the main option for high‐risk hemangiomas (86.4%), timolol for intermediate‐risk (36.8%), and observation for low‐risk ones (55.9%). The intra‐rater agreement was good. The inter‐rater agreement between pediatric dermatologists on the treatment of IH is only fair. Variability was most significant with intermediate‐ and low‐risk hemangiomas.