bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spread through Air Spaces (STAS) in Solitary Pulmonary Metastases from Colorectal Cancer (CRC)
Authors: Haj Khalaf Mohamed Anwar , Sirbu Horia , Hartmann Arndt , Agaimy Abbas , Dudek Wojciech , Higaze Mostafa , Rieker Ralf 
Published: October 2022

Abstract
Background Spread through air spaces (STAS) is a recently described route of tumor invasion associated with poor prognosis in primary lung cancer. Aim of this study was to investigate the presence of STAS and to assess its prognostic significance in patients undergoing pulmonary metastasectomy (PM) for solitary metastases from colorectal cancer (CRC).
Materials and Methods All 49 CRC patients (30 male and 19 female, median age 66 years) who underwent PM between January 2008 and December 2015 were retrospectively analyzed.
Results STAS was identified in 26.5% (n = 13) of resected specimens. Location of pulmonary lesions (central vs. peripheral) was assessed based on the available computed tomography imaging (n = 47, 96%). STAS was detected in all five patients with central metastases (100%) versus 7 of 42 (17%) with peripheral metastases (p = 0.0001). Locoregional recurrence occurred in STAS-positive patients (n = 4 of 13 vs. n = 0 of 36), all STAS-negative patients remained recurrence-free (p = 0.003). Median number of alveoli with STAS involvement was four (range from 2 to 9). There was statistically positive relationship between the number of alveoli invaded with STAS and locoregional recurrence of metastases (p = 0.0001). The presence of STAS is not a factor affecting the 5-year overall survival rate (p = 0.6651).
Conclusion We identified STAS as a frequent finding in resected CRC lung metastases and found insignificant association with outcome.
Non-invasive assessment of oocyte developmental competence
Authors: Tan Tiffany C. Y. , Dunning Kylie R. 
Published: October 2022

Oocyte quality is a key factor influencing IVF success. The oocyte and surrounding cumulus cells, known collectively as the cumulus oocyte complex (COC), communicate bi-directionally and regulate each other’s metabolic function to support oocyte growth and maturation. Many studies have attempted to associate metabolic markers with oocyte quality, including metabolites in follicular fluid or ‘spent medium’ following maturation, gene expression of cumulus cells and measuring oxygen consumption in medium surrounding COCs. However, these methods fail to provide spatial metabolic information on the separate oocyte and cumulus cell compartments. Optical imaging of the autofluorescent cofactors – reduced nicotinamide adenine dinucleotide (phosphate) [NAD(P)H] and flavin adenine dinucleotide (FAD) – has been put forward as an approach to generate spatially resolved measurements of metabolism within individual cells of the COC. The optical redox ratio (FAD/[NAD(P)H + FAD]), calculated from these cofactors, can act as an indicator of overall metabolic activity in the oocyte and cumulus cell compartments. Confocal microscopy, fluorescence lifetime imaging microscopy (FLIM) and hyperspectral microscopy may be used for this purpose. This review provides an overview of current optical imaging techniques that capture the inner biochemistry within cells of the COC and discusses the potential for such imaging to assess oocyte developmental competence.
Investigating pragmatic failure in L2 English email writing among Japanese university EFL learners
Authors: Nicholas Allan , Blake John , Mozgovoy Maxim , Perkins Jeremy 
Published: October 2022

Abstract
English L2 email is an important mode of communication for Japanese university learners. However, learners often
find it challenging to vary register in a pragmatically-appropriate manner when emailing. Identifying specific aspects of English
email writing that learners find challenging can provide the basis for addressing learner needs. A corpus approach can help,
systematically identifying instances of perceived divergence from register-specific norms in an email dataset. Few learner
corpora, however, have focused on appropriate register variation in learner L2 English. This article describes the development,
annotation, and analysis of a specialized corpus of Japanese university English L2 learners’ request-based email writing,
annotated for perceived instances of pragmatic failure. Findings show high frequencies of perceived pragmatic failure across all
aspects of English L2 email writing, with participants struggling to appropriately adapt their language to varying contexts.
Implications for the language learning classroom are discussed.
Cholesterol: Enhancing FGF2 translocation in unconventional secretion
Authors: Wang Haodong , Zhang Min , Ge Liang 
Published: October 2022

Fibroblast growth factor (FGF2) is a potent mitogen that is secreted through an unconventional secretory pathway by crossing the plasma membrane directly. In this current issue, Lolicato et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202106123) find that the secretion process is promoted by cholesterol, which enhances PI(4,5)P2 accessibility to FGF2 binding and alters membrane property to increase FGF2 translocation.
Structure and trophic organisation of the macrobenthic community of the Hassar stream after installation of the Mediouna wastewater treatment plant (Casablanca, Morocco)
Authors: Nahli A , Sghiouer F E , Oubraim S , Chlaida M 
Published: October 2022

Abstract
The goal of this research is to assess changes in the structure of benthic macroinvertebrate Functional Feeding Groups (FFGs) in the Hassar Stream (north-east of Casablanca) after the Mediouna wastewater treatment plant (WWTP) was installed. Over the course of a year, from November 2013 to October 2014, data on water quality and macroinvertebrate fauna are gathered at seven sampling stations. To measure the resilience of FFGs, macroinvertebrates are used to analyse the influence of physicochemical water quality on their organisation. Based on FFGs abundance, Collector-gatherers make up 39.06 percent of the macroinvertebrates’ assemblage, followed by shredders (28.41 percent) and collector-filters (28.41 percent) (18.76 percent). Except for the upstream stations (S1 and S2), the FFGs ratios indicated that the environment is largely heterotrophic, has a significant relationship with riparian inputs, and generally stable substrates. These findings emphasise the necessity of researching macroinvertebrate FFGs as a supplement to measuring the ecological integrity and resilience of rivers after anthropogenic impact reduction.
Assessment of soil erosion rate using the EPM model : case of Ouaoumana basin, Middle Atlas, Morocco.
Authors: Ennaji N , Ouakhir H , Halouan S , Abahrour M 
Published: October 2022

Abstract
Soil erosion and land degradation are considered serious problems, decrease soil fertility, flooding, and silting of dams, which makes soil conservation and control of erosion risk are basic issues in all countries. The crucial aim of this study is to evaluate the soil erosion rates and to spatialize its hazard, by applying an empirical model namely the erosion potential model (EPM), known also as the Gavrilovic method. Located in the Middle Atlas of Morocco, the chosen study area is known as the Ouaoumana basin, which is a small mountainous area. In terms of climate, it can be classified as the Mediterranean with mountainous influence. The studied area is characterized by an annual rainfall average range between 378 and 513 mm. Consequently, the obtained results were evaluated using GIS software and compared in terms of two different representative catchments. The criteria of selecting the two studied headwaters are; different localization within the Ouaoumana basin, land uses, slopes, and lithology. The Tiguert catchment (a) which is located in the downstream part, is moderately eroded with a rate of less than 39007 m3/km2/yr-1. In inverse, the Wanmroud catchment (b) is situated in the upstream part of the studied basin, and is highly eroded due to lithology, slopes, and land use impacts. Besides, within this catchment (b) the produced soil erosion rate varies from 222 to more than 164420 m3/km2/yr1.
Geoenvironmental characterization of two REE deposits: the Montviel carbonatites and Kipawa silicates, Quebec Canada
Authors: Edahbi M , Plante B , Benzaazoua M , Cayer A 
Published: October 2022

Abstract
Drainage water quality is the significant environmental concern for the rare earth elements (REE) mining industry. REE deposits are associated with other metals and radioactive bearing minerals. REE mining and refining activities can generate significant quantities of liquid and solid wastes. Therefore, a long-term integrated approach covering the full mine-life cycle is required to mitigate possible environmental concerns. In the present study, two REE concentrates were prepared and all deposit lithologies of carbonatites and silicates sampled and investigated for their mineralogy, geochemistry, and their environmental behavior using kinetic testing. For the Montviel carbonatite (enriched in light rare earth elements, or LREE), the majority of REE-bearing minerals are associated with carbonates (i.e., monazite, kukharenkoite, burbankite, etc.), whereas the REE-bearing minerals associated with the Kipawa silicates (enriched in heavy rare earth elements, or HREE) are fluorbritholite, eudyalite, mosandrite, etc. The kinetic tests showed a neutral to alkaline pH of leachates and a low leachability of REE (carbonatites <140 μg/L; silicates <15 μg/L) with a higher mobility of HREE than LREE. The reactivity of REE carbonates are one to two orders of magnitude higher than REE silicates. For sustainable mineral development, geological and environmental data was integrated into the geometallurgical model to identify and control the environmental risks associated with mining those two deposits.
Floristic analysis of the medicinal flora used by the population of the Central Middle Atlas (Morocco)
Authors: Hachi M , Hachi T , Essabiri H , Ainane T , El Yaakoubi A , Zidane L 
Published: October 2022

Abstract
Within the scope of the exploitation of natural resources, an ethnobotanical and floristic study was carried out in the Central Middle Atlas to identify the medicinal plants used in traditional medicine and to collect as much information as possible about the local knowledge held by the local population. Ethnobotanical field surveys were conducted during two campaigns (2013 and 2014) using a questionnaire sheet. The location of the different ethnobotanical and floristic surveying environments was identified by the stratified sampling method. The survey was carried out among 1560 inhabitants randomly selected from the population of the study area with a sample of 40 persons per stratum. The results of these surveys have enabled us to draw up a catalog of 267 medicinal species divided into 211 genera and 79 families, among which: 6 are the most represented, including Asteraceae, Lamiaceae, Apiaceae, Rosaceae, Fabaceae and Poaceae. Oregano (Origanum compactum Benth.) is the most used species. The elaborated catalog is characterized by the presence of endemic species of Morocco and also by the presence of rare or threatened taxa with a percentage of 6, 36 % of the listed species. The study contributes to improving knowledge about traditional medicine and safeguarding folk knowledge. but abusive gathering can put wild medicinal species at risk, many populations of local medicinal species suffer from overexploitation. Thus, it is necessary to provide legislative measures capable of protecting them and also to create specialized nurseries in order to curb the abuse of use and direct it towards a more rational and scientific use.
Growth Rate Analysis Casuarina equisetifolia of The Case Study Pacitan and Samas Coast Area
Authors: Purwono N A S 
Published: October 2022

Abstract
The southern coast of Java is an area that is prone to earthquakes and tsunamis because the area is a meeting of the Pacific plate and the Indo-Australian plate meeting the South American continental plate, and the North American plate meeting the Philippine plate. The tsunami disaster can cause significant loss of life and material and cause damage to infrastructure in coastal areas. Casuarina equisetifolia is one type of vegetation that can grow in the southern coastal area of Java, where the coastal morphology is dominated by sand-type material used for protection from wind waves. The primary survey carried out in this study was to obtain the dimensions of coastal forest plants. The results of the Casuarina measurements were the age of 2 to 4 years at the Samas Coast area and 1 to 9 years were made at Teleng Ria Coast area. The analyzing show that increasing logarithmic function of Casuarina the trend of increasing growth of Casuarina tree height. It ages the older the tree height will increase, but this does not apply to the thickness of the tree canopy that grows to the side, because influenced by the position of the shoreline and the plant spacing factor.
The vulnerability of Small Islands from Coastlines Change in Indonesia
Authors: Rahmadi M M , Liviawaty E , Faizal I , Purba N P , Ramadhan R A , Amrullah R , Dianti I E 
Published: October 2022

AbstractIndonesia has 16.100 islands and 92 is outermost islands. These small islands are currently experiencing the impact of climate change from sea level rise and global warming. This study aims to determine vulnerability of small island through changes in coastline and dynamic change of area due to climate change especially from coastline changes. Nineteen islands selected as representation of Indonesia seas regions. The data were collected from satellite images range from 2000 to 2020. To analyze, this research method uses Coastsat method to detect coastlines and QGIS to process coastline data and change of the island areas. The results of this study indicate that the average reduction in the area of small islands in Indonesia reaches 5.084% for approximately 20 years. Overall, the change in the area shows that most of the small outermost islands in Indonesia have Medium vulnerability
The Distribution of Temperature on Aerobic Composting of Food Waste: Experimental studies and CFD analysis.
Authors: Warmadewanthi IDAA , Krisnaputra A.B. , Saptarini D , Andiya A. M. , Mahubessy R.C. , Humaidi F. 
Published: October 2022

Abstract
Food waste generation has a significant impact on the economy, society, and environment. Indonesia as the second-largest contributor of food waste, face this problem. Food waste generation increased for 20 years and contributed to more than 40% of solid waste in Indonesia. The government has a strategy to reduce the generation and disposal of food waste in landfills. One of the methods used is by recycling used composting. The composting method that is usually used is aerobic composting. Several factors affected the process and the rate-limiting step in oxygen concentration. This paper aims to analyze the effect of oxygen on the temperature during composting. Temperature is one of the parameters that could be used to analyze the process and determine the maturity of compost.
The research in this paper utilized CFD modeling to describe the dynamic changes and spatial distribution of temperature in the aerobic composting process using mass-heat-momentum coupling based on microbial mechanisms. The equations used are based on several previous research and journals. Composting experiments were carried out with the aeration method at intervals to verify the proposed model. The microorganisms’ growth affects oxygen concentration which then affects the temperature distribution of the composting process. The simulation results show that the model accurately predicts the dynamic temperature changes and their distribution on the composting substrate. The proposed CFD model shows promising results and simulates the actual working conditions of the aerobic composting process.
Recommendations for planning water infrastructure in the Surabaya City area with the influence of watershed characteristics to realize sustainable settlement drainage that is safe from flooding
Authors: Imaaduddiin Muhammad Hafiizh , Saud Ismail , Santoso Rahmad Putra 
Published: October 2022

Abstract
The development of urban areas often has an impact on changes in the surface run off area of water flow, a consequence that often occurs is flooding due to an increase in the value of run off drainage from housing/industries which burdens the capacity of urban land drainage channels. The analysis carried out is to calculate the value of the travel time (Tc) from the build area compared to the peak time (Tp) in the urban partial drainage flow. The value of time concentration is influenced by the slope of topography and watershed area of each rayon in Surabaya. The calculated Tc and Tp values will be combined to find the linear correlation value of the effect of watershed characteristics on development/change of land area in Surabaya. The results of the linear analysis of the relationship between the area of the build up area and the combined travel time in each rayon are not the same, this is due to the influence of land topographic slopes in each rayon and also the area of the watershed be different. the length of the channel on the drainage of urban area in each rayon have a separate drainage network sub system from one another. This is a consideration that the determination of the formulation of the relationship between the area of the build up area and the time and volume of the reservoir must adjust the characteristics of each rayon.
Removal of COD and TSS from tomato ketchup industrial wastewater using cylindrical electrocoagulation method
Authors: Syaifuddin M , Bagastyo A Y 
Published: October 2022

Abstract
Tomato ketchup industrial sector is associated with various environmental problems including high concentration wastewater containing organic pollutant and suspended solid. While the industry always considers from an economic point of view, electrocoagulation can be the best alternative of treat wastewater which has the advantage easy in operation, minimum space requirements, low volumes of sludge produced, and can be used in high concentration wastewater. This paper investigated the effect of pH and current electricity on performance of removal of COD and TSS in tomato ketchup wastewater treatment. The research was conducted in continuous flow using cylindrical reactor with rod aluminum anode dan helical stainless-steel cathode, while the pH and current variations were 6, 7, 8 and 30 A, 35 A, and 40 A respectively. Based on analyzed data, aluminum has an effectiveness in COD and TSS removal. On the other hand, pH and current has a significant role on the process of removing COD and TSS. The best removal of COD and TSS was under the 35 A and pH 8 condition with 81,86 % (103.24 gCOD) and 82.61% (6.48 gTSS).
Uncovering Heterogeneous Associations Between Disaster-Related Trauma and Subsequent Functional Limitations: A Machine-Learning Approach
Authors: Shiba Koichiro , Daoud Adel , Hikichi Hiroyuki , Yazawa Aki , Aida Jun , Kondo Katsunori , Kawachi Ichiro 
Published: October 2022

Abstract
This study examined heterogeneity in the association between disaster-related home loss and functional limitations of older adults, and identified characteristics of vulnerable subpopulations. Data were from a prospective cohort study of Japanese older survivors of the 2011 Japan Earthquake. Complete home loss was objectively assessed. Outcomes in 2013 (n = 3,350) and 2016 (n = 2,664) included certified physical disability levels, self-reported activities of daily living, and instrumental activities of daily living. We estimated population average associations between home loss and functional limitations via targeted maximum likelihood estimation with SuperLearning and its heterogeneity via the generalized random forest algorithm. We adjusted for 55 characteristics of survivors from the baseline survey conducted 7 months before the disaster. While home loss was consistently associated with increased functional limitations on average, there was evidence of effect heterogeneity for all outcomes. Comparing the most and least vulnerable groups, the most vulnerable group tended to be older, not married, living alone, and not working, with preexisting health problems before the disaster. Individuals who were less educated but had higher income also appeared vulnerable for some outcomes. Our inductive approach for effect heterogeneity using machine learning algorithm uncovered large and complex heterogeneity in postdisaster functional limitations among Japanese older survivors.
Anterior connectivity critical for recovery of connected speech after stroke
Authors: Ding Junhua , Schnur Tatiana T 
Published: October 2022

Abstract
Connected speech recovers to different degrees across people after left hemisphere stroke, but white matter predictors of differential recovery from the acute stage of stroke are unknown. We assessed changes in lexical–syntactic aspects of connected speech in a longitudinal analysis of 40 individuals (18 females) from the acute stage of left hemisphere stroke (within an average of 4 days post-stroke) to subacute (within 2 months) and chronic stages (early: 6 months, late: 1 year) while measuring the extent of acute lesions on white matter tracts to identify tracts predictive of recovery. We found that acute damage to the frontal aslant tract led to a decreased recovery of the fluency and structural complexity of connected speech during the year following left hemisphere stroke. The results were independent of baseline performance, overall lesion volume and the proportion of damage to tract-adjacent grey matter. This longitudinal analysis from acute to chronic stroke provides the first evidence that recovery of fluent and structurally complex spontaneous connected speech requires intact left frontal connectivity via the frontal aslant tract. That the frontal aslant tract was critical for recovery at early as well as later stages of stroke demonstrates that anterior connectivity plays a lasting and important role for the reorganization of function related to the successful production of connected speech.
Brainnetome atlas of preadolescent children based on anatomical connectivity profiles
Authors: Li Wen , Fan Lingzhong , Shi Weiyang , Lu Yuheng , Li Jin , Luo Na , Wang Haiyan , Chu Congying , Ma Liang , Song Ming , Li Kaixin , Cheng Luqi , Cao Long , Jiang Tianzi 
Published: October 2022

Abstract
During the preadolescent period, when the cerebral thickness, curvature, and myelin are constantly changing, the brain's regionalization patterns underwent persistent development, contributing to the continuous improvements of various higher cognitive functions. Using a brain atlas to study the development of these functions has attracted much attention. However, the brains of children do not always have the same topological patterns as those of adults. Therefore, age-specific brain mapping is particularly important, serving as a basic and indispensable tool to study the normal development of children. In this study, we took advantage of longitudinal data to create the brain atlas specifically for preadolescent children. The resulting human Child Brainnetome Atlas, with 188 cortical and 36 subcortical subregions, provides a precise period-specific and cross-validated version of the brain atlas that is more appropriate for adoption in the preadolescent period. In addition, we compared and illustrated for regions with different topological patterns in the child and adult atlases, providing a topologically consistent reference for subsequent research studying child and adolescent development.