bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of the Defect Passivation in Perovskite Materials Using Organic Spacer Cations
Authors: Shen Kongchao , Wang Jingkun , Lu Yu , Shen Yang , Li Yan‐Qing , Su Zhenhuang , Chen Li , Song Fei , Gao Xingyu , Tang Jian‐Xin 
Published: February 2022

AbstractQuasi‐2D metal halide perovskite light emitting diodes (PeLEDs) have attracted a lot of attentions in recent years, while their potential applications in displays and lighting are limited by the device stability. Although defect passivation in PeLEDs is an effective method to ameliorate the unstable problem, the underlying mechanisms need to be further explored. Herein, organic spacer cations with different charge distributions and formation energies in quasi‐2D CsPbBr3 perovskites are utilized to unravel the defect passivation mechanisms, including phenylmethanamine, 2‐phenylethanamine bromide, and 4‐phenylbutylammonium. The experimental findings and density functional theory calculation reveal that the defect passivation occurs by the electrostatic interaction between defective PbBr64− octahedrons and proper organic spacer cations during the annealing process, particularly at the grain boundaries. The thermal stability of the perovskite films and device performance are improved after the effective defect passivation process. The exploration of the defect passivation process in perovskites will be beneficial to the development of high‐performance PeLEDs.
IL‐36γ and IL‐36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis by Modulating the Cell–Matrix Adhesion Network and Wnt Signaling
Authors: Yang Wei , Dong Hong‐Peng , Wang Peng , Xu Zhi‐Gao , Xian Jiahuan , Chen Jiachen , Wu Hai , Lou Yang , Lin Dandan , Zhong Bo 
Published: February 2022

AbstractInflammatory bowel disease and colorectal cancer are associated with dysregulation of cytokine networks. However, it is challenging to target cytokines for effective intervention because of the overlapping functions and unpredictable interactions of cytokines in such diverse networks. Here, it is shown that IL‐36γ and IL‐36Ra, an agonist and an antagonist for IL‐36R signaling respectively, reciprocally regulate the experimental colitis and the colon cancer development in mice. Knockout or neutralization of IL‐36γ alleviates dextran sulfate sodium (DSS)‐induced colitis and inhibits colon cancer development, whereas knockout of IL‐36Ra exacerbates DSS‐induced colitis and promotes colonic tumorigenesis in multiple colon cancer models in mice. Mechanistically, IL‐36γ upregulates extracellular matrix and cell–matrix adhesion molecules and facilitates Wnt signaling, which is mitigated by IL‐36Ra or IL‐36γ neutralizing antibody. Consistently, IL‐36γ levels are positively correlated with extracellular matrix levels and β‐catenin levels in human colorectal tumor biopsies. These findings suggest the critical role of IL‐36γ and IL‐36Ra in gut inflammation and tumorigenesis and indicate that targeting the IL‐36γ/IL‐36Ra signal balance provides potential therapeutic strategy for inflammatory bowel disease and gastrointestinal cancers.
Do state Supplemental Nutrition Assistance Program policies influence program participation among seniors?
Authors: Jones Jordan W. , Courtemanche Charles , Denteh Augustine , Marton James , Tchernis Rusty 
Published: February 2022

AbstractSenior participation in the Supplemental Nutrition Assistance Program (SNAP) has traditionally been lower than other groups among those eligible, with historical estimates below 50%. We examine the impacts of state SNAP policies on program participation among low‐income senior (age 60 and older) and nonsenior households using data from the 2001 to 2014 December Current Population Survey Food Security Supplement. Our results suggest that policies designed to expand SNAP eligibility modestly increased participation among seniors but led to larger increases among nonseniors. In contrast, we find little evidence of effects of policies related to transaction costs, stigma, or outreach on either group.
On the parameter refinement of inflated exoplanets with large radius uncertainty based on TESS observations
Authors: Alexoudi Xanthippi 
Published: February 2022

AbstractWe revisited 10 known exoplanetary systems using publicly available data provided by the transiting exoplanet survey satellite (TESS). The sample presented in this work consists of short period transiting exoplanets, with inflated radii and large reported uncertainty on their planetary radii. The precise determination of these values is crucial in order to develop accurate evolutionary models and understand the inflation mechanisms of these systems. Aiming to evaluate the planetary radius measurement, we made use of the planet‐to‐star radii ratio, a quantity that can be measured during a transit event. We fit the obtained transit light curves of each target with a detrending model and a transit model. Furthermore, we used emcee, which is based on a Markov chain Monte Carlo approach, to assess the best fit posterior distributions of each system parameter of interest. We refined the planetary radius of WASP‐140 b by approximately 12%, and we derived a better precision on its reported asymmetric radius uncertainty by approximately 86 and 67%. We also refined the orbital parameters of WASP‐120 b by . Moreover, using the high‐cadence TESS datasets, we were able to solve a discrepancy in the literature, regarding the planetary radius of the exoplanet WASP‐93 b. For all the other exoplanets in our sample, even though there is a tentative trend that planetary radii of (near‐) grazing systems have been slightly overestimated in the literature, the planetary radius estimation and the orbital parameters were confirmed with independent observations from space, showing that TESS and ground‐based observations are overall in good agreement.
Genome Editing‐accelerated Re‐Domestication (GEaReD) – A new major direction in plant breeding
Authors: Hanak Tobias , Madsen Claus Krogh , Brinch‐Pedersen Henrik 
Published: February 2022

BackgroundThe effects of climate change, soil depletion, a growing world population putting pressure on food safety and security are major challenges for agriculture in the 21st century. The breeding success of the green revolution has decelerated and current programs can only offset the yield affecting factors.Purpose and scopeNew approaches are urgently needed and “Genome Editing‐accelerated Re‐Domestication” (GEaReD) is proposed as a major new direction in plant breeding. By combining the upcoming technologies for phenotyping, omics, and artificial intelligence with the promising new CRISPR‐toolkits, this approach is closer than ever.Summary and conclusionWild relatives of current crops are often adapted to harsh environments and have a high genetic diversity. Redomestication of wild barley or teosinte could generate new cultivars adapted to environmental changes. De novo domestication of perennial relatives such as Hordeum bulbosum could counter soil depletion and increase soil carbon. Recent research already proved the principle of redomestication in tomato and rice and therefore laid the foundation for GEaReD.
Extracellular vesicles facilitate large‐scale dynamic exchange of proteins and RNA among cultured Chinese hamster ovary and human cells
Authors: Belliveau Jessica , Papoutsakis Eleftherios T. 
Published: February 2022

AbstractCells in culture are viewed as unique individuals in a large population communicating through extracellular molecules and, more recently extracellular vesicles (EVs). Our data here paint a different picture: large‐scale exchange of cellular material through EVs. To visualize the dynamic production and cellular uptake of EVs, we used correlative confocal microscopy and scanning electron microscopy, as well as flow cytometry to interrogate labeled cells. Using cells expressing fluorescent proteins (GFP, miRFP703) and cells tagged with protein and RNA dyes, we show that Chinese hamster ovary (CHO) cells dynamically produce and uptake EVs to exchange proteins and RNAs at a large scale. Applying a simple model to our data, we estimate, for the first time, the per cell‐specific rates of EV production (68 and 203 microparticles and exosomes, respectively, per day). This EV‐mediated massive exchange of cellular material observed in CHO cultures was also observed in cultured human CHRF‐288‐11 and primary hematopoietic stem and progenitor cells. This study demonstrates an underappreciated massive protein and RNA exchange between cells mediated by EVs spanning cell type, suggesting that the proximity of cells in normal and tumor tissues may also result in prolific exchange of cellular material. This exchange would be expected to homogenize the cell‐population cytosol and dynamically regulate cell proliferation and the cellular state.
The microbiota‐gut‐brain axis and epilepsy from a multidisciplinary perspective: Clinical evidence and technological solutions for improvement of in vitro preclinical models
Authors: Fusco Federica , Perottoni Simone , Giordano Carmen , Riva Antonella , Iannone Luigi Francesco , De Caro Carmen , Russo Emilio , Albani Diego , Striano Pasquale 
Published: February 2022

AbstractEpilepsy is a common neurological disease characterized by the enduring predisposition of the brain to generate seizures. Among the recognized causes, a role played by the gut microbiota in epilepsy has been hypothesized and supported by new investigative approaches. To dissect the microbiota‐gut‐brain (MGB) axis involvement in epilepsy, in vitro modeling approaches arouse interest among researchers in the field. This review summarizes, first of all, the evidence of a role of the MGB axis in epilepsy by providing an overview of the recent clinical and preclinical studies and showing how dietary modification, microbiome supplementations, and hence, microbiota alterations may have an impact on seizures. Subsequently, the currently available strategies to study epilepsy on animal and in vitro models are described, focusing attention on these latter and the technological challenges for integration with already existing MGB axis models. Finally, the implementation of existing epilepsy in vitro systems is discussed, offering a complete overview of the available technological tools which may improve reliability and clinical translation of the results towards the development of innovative therapeutic approaches, taking advantage of complementary technologies.
Anesthetic management in a patient with Arnold‐Chiari malformation type 1,5: A case report
Authors: Coviello Antonio , Golino Ludovica , Posillipo Concetta , Marra Annachiara , Tognù Andrea , Servillo Giuseppe 
Published: February 2022

AbstractA 42‐year‐old male patient with Arnold‐Chiari malformation type 1,5 (ACM‐1,5) came to implant a hip prosthesis. He underwent a previous general anesthesia, with difficult airway management and complication in awakening. In this second surgery, an extradural approach was preferred to keep intracranial pressure and hemodynamics stable.
Laparoscopic surgery for a hydrocele of the canal of Nuck with an ovarian tumor: An extremely rare clinical finding
Authors: Tominaga Marie , Morikawa Kyoko , Ogawa Yutaro , Kamimura Naomi , Tsuneki Ikunosuke , Tamura Masaki , Yanase Toru , Kobayashi Kazuaki , Sato Daisuke , Kameyama Hitoshi , Iwaya Akira , Yokoyama Naoyuki , Kuwabara Shiro , Yamazaki Toshiyuki , Otani Tetsuya , Kurabayashi Takumi 
Published: February 2022

AbstractThis clinical image presents an unusual report of simultaneous laparoscopic resection of a hydrocele of the canal of Nuck and an ovarian tumor. Laparoscopic treatment with a proper approach is a useful technique in some cases.
Severe hyponatremia as the presenting manifestation of primary empty sella syndrome
Authors: Takkavatakarn Kullaya , Wipattanakitcharoen Aschariya , Katavetin Pisut , Eiam‐Ong Somchai 
Published: February 2022

AbstractSevere hyponatremia is associated with neurological impairment and mortality. Furthermore, severe hyponatremia can be the first presentation of several diseases. Therefore, an appropriate investigation for the underlying causes of hyponatremia apart from the proper correction of sodium levels, might lead to a diagnosis of occult diseases.
Confluent and reticulated papillomatosis of Gougerot–Carteaud in a North African patient
Authors: Elinkichari Dorsaf , Jaber Kahena , Rabhi Faten , Dhaoui Raouf 
Published: February 2022

AbstractConfluent and reticulated papillomatosis (CRP) is an underdiagnosed skin condition of uncertain etiology. The antibacterial and most importantly the anti‐inflammatory mechanisms of some antibiotics seem to explain the effectiveness of these medications. Other measures such as reducing weight and treating an underlying endocrine disorder may be helpful.
Preference for sublingual immunotherapy with tablets in a Spanish population with allergic rhinitis
Authors: Bøgelund Mette , Ingelmo Ana Rosado , Ruiz Jose María Ausín , Vivó Adolfo Galán , Brandi Henrik , Pedersen Mikkel Hasse , Loftager Anne Sofie Ledgaard , Aagren Mark 
Published: February 2022

AbstractBackgroundThis study investigated patients' preference for allergy immunotherapy (AIT) administered as either sublingual immunotherapy‐tablets versus monthly or weekly subcutaneous immunotherapy (SCIT) from a Spanish patient perspective.MethodsA discrete choice experiment (DCE) consisting of two blocks with eight choice sets in each was constructed to elicit the preferences for AIT. Three attributes were included in the DCE for the mode of administration, including the frequency of administration, the risk of systemic reactions and the co‐payment. Adults and caregivers of children with moderate to severe allergic rhinitis (AR) were included if they were not currently receiving or had not previously received AIT.ResultsIn total, 587 adults and 613 caregivers started the survey. Of those, 579 adults and 611 caregivers completed the survey and were included in the study. Both adults and caregivers had a significant preference for tablets compared with both monthly and weekly injections (p ≤ 0.0001). Furthermore, the respondents showed a significant preference for reducing the risk of systemic reactions. Subgroup analyses showed that caregivers of polyallergic children and female caregivers were significantly less price sensitive when choosing their preferred treatment.ConclusionOur study demonstrated that both adults with AR and caregivers of children with AR prefer daily SLIT‐tablets to SCIT with either a weekly or monthly dose schedule.
Association between timely targeted treatment and outcomes in patients with metastatic HER2‐overexpressing gastroesophageal adenocarcinoma
Authors: Lau‐Min Kelsey S. , Li Yimei , Eads Jennifer R. , Mamtani Ronac , Getz Kelly D. 
Published: February 2022

BackgroundTimely targeted treatment initiation can be challenging because additional biomarker testing is needed for eligibility. The authors hypothesized that timely targeted treatment improves survival relative to nontimely initiation in metastatic HER2+ gastroesophageal adenocarcinoma (GEA).MethodsThe authors performed a retrospective cohort study of metastatic HER2+ GEA treated with first‐line (1L) systemic therapy from January 2011 to December 2017 using a nationwide electronic health record–derived deidentified database. Timely targeted treatment—trastuzumab initiation within 14 days after starting 1L chemotherapy—was assessed as a time‐varying exposure. Nontimely targeted treatment included patients who initiated trastuzumab after 14 days or who lacked documentation of receiving trastuzumab. Extended Cox regressions compared overall survival (OS) and progression‐free survival (PFS) between timely and nontimely groups.ResultsA total of 320 patients were included; 59.1% received timely trastuzumab. Relative to nontimely initiation, timely trastuzumab was associated with significantly higher OS (2‐year OS, 32.1% vs 15.3%; adjusted hazard ratio [HR], 0.67; 95% CI, 0.51‐0.88) and PFS (2‐year PFS, 9.2% vs 3.7%; adjusted HR, 0.71; 95% CI, 0.55‐0.93). Results remained similar in sensitivity analyses 1) using alternative “timeliness” definitions up to 70 days after starting 1L chemotherapy, 2) comparing any trastuzumab, regardless of timing of initiation, to no trastuzumab, and 3) excluding patients lacking documentation of receiving trastuzumab.ConclusionsImproved survival was observed among metastatic HER2+ GEA patients treated with trastuzumab versus those who were not, regardless of timing of initiation. Although these results reassure clinicians that modest targeted treatment delays may not be detrimental to outcomes, efforts should still ensure that all metastatic HER2+ GEA patients receive trastuzumab.
Energy storage and stress–strain characteristics of a prosthetic foot: a priori design and analysis with experiments
Authors: Mannan Balaramakrishnan Thirunindravur , Natarajan Sundararajan , Sujatha Srinivasan 
Published: February 2022

AbstractThis work proposes an experimentally validated numerical approach for a systematic a priori evaluation of the energy storage and stress–strain characteristics of a prosthetic foot during the stance phase of walking. Boundary conditions replicating the rocker based inverted pendulum model were incorporated. The mechanically complex Ottobock Solid Ankle Cushioned Heel (SACH) foot was opted as the test device. A non‐linear finite element (FE) model of the device was developed inclusive of its sources of non‐linearity. A custom rig was fabricated to investigate the prosthetic foot's mechanics in a gait analysis facility and experimentally validate the finite element approach. The numerical and experimental outcomes showed fair agreement, with the centre of pressure at the foot–floor interface deviating by 1.56 mm at the instance of highest strain. The magnitude and the distribution of the energy stored and a series of stress and strain parameters were analyzed for the test device using the proposed approach. The novel methodology proposed may act as an effective tool for the design, analysis, and prescription of energy storage and return prosthetic feet.
Drivers of corporate social responsibility and firm performance for sustainable development—An institutional theory approach
Authors: Ng Peggy M. L. , Wut Tai Ming , Lit Kam Kong , Cheung Cherry T. Y. 
Published: February 2022

AbstractChinese companies are aware of the importance of corporate social responsibility (CSR) nowadays, but the drivers of CSR practices or activities are unknown. To bridge this research gap, this study examined the links between both internal and external factors and firm performance in the Chinese context and developed a new theoretical framework integrating the indigenous characteristics of CSR in China to predict the factors that affect Chinese CSR. Data from 530 Chinese managers from manufacturing and non‐manufacturing firms were collected via a survey through SoJump (sojump.com) and analysed using structural equation modelling. One internal institutional factor (top management commitment) and three external factors (environmental legislative pressure, peer imitation pressure and normative social pressure) were found to strongly and positively predict CSR practices. The major contribution of this study is that, it demonstrates the intervening role of CSR practices in strengthening firm performance from a management perspective.
Revascularization in ischaemic heart failure with preserved ejection fraction: a nationwide cohort study
Authors: Deo Salil V. , Reddy Yogesh N.V. , Zakeri Rosita , Karnib Mohamad , Selvaganesan Padmini , Elgudin Yakov , Kilic Ahmet , Rubelowsky Joseph , Altarabsheh Salah E. , Osman Mohammed N. , Josephson Richard A. , Mohan Sri Krishna Madan , Cmolik Brian , Simon Daniel I. , Rajagopalan Sanjay , Cleland John G.F. , Sahadevan Jayakumar , Sundaram Varun 
Published: February 2022

AimsDespite the common occurrence of coronary artery disease (CAD) and heart failure (HF) with preserved ejection fraction (HFpEF), there is limited evidence to guide revascularization.Methods and ResultsWe investigated the long‐term outcomes of coronary artery bypass grafting (CABG) in patients with HF and significant CAD across the spectrum of ejection fraction, using a large national cohort of patients from the Veteran Affairs (VA) Medical Centers in the US. Patients with HF were stratified into groups, HFpEF, HF with mid‐range ejection fraction (HFmrEF), and HF with reduced ejection fraction (HFrEF) and compared to patients with no preoperative HF. We analysed 10 396 patients. Despite an increased hazard in the first year following revascularization, the long‐term survival (median follow‐up 6.6 years; interquartile range 3.7–10.1) of HFpEF post‐CABG was similar to controls (hazard ratio 0.85, 95% confidence interval 0.68‐1.06), but survival progressively declined with HFmrEF and HFrEF. Similar trends were seen with recurrent HF hospitalization with lower risk with baseline HFpEF (43.9 ± 6.9/100 patient‐years) compared to HFmrEF (65.9 ± 3.8/100 patient‐years) and HFrEF (93.4 ± 4.8/100 patient‐years). Although HFpEF patients had lower mortality and HF hospitalization post‐CABG compared to patients with a lower ejection fraction, they experienced the highest rates of future myocardial infarction.ConclusionAlthough HFpEF patients with CAD have greater short‐term risk post‐CABG, their long‐term survival is comparable to controls. However, they are at increased risk for HF hospitalizations and myocardial infarction. These data support the safety of CABG in HFpEF patients and suggest continuum of mortality risk for ischaemic HF when stratified by baseline ejection fraction before revascularization.
Drug therapy for heart failure with reduced ejection fraction: what is the ‘right’ dose?
Authors: Kondo Toru , Jhund Pardeep S. , McMurray John J.V. 
Published: February 2022

ABSTRACTNew guidelines have emphasized the primacy of starting the four key life‐saving therapies for patients with heart failure and reduced ejection fraction as quickly as possible, with titration to ‘target dose’ of these, as secondary consideration. In this article, we examine the reasons for this change in emphasis and revisit the evidence regarding the dosing of pharmacological therapy in heart failure. We demonstrate the early benefits obtained with even low doses of most of the foundational therapies for heart failure and reduced ejection fraction. We also clarify that the ‘target dose’ of those therapies requiring titration was a goal based on tolerability and often not reached in trials, i.e. the proven benefits of our foundational therapies were demonstrated with an average dose that was less than target and many patients in these trials were treated with sub‐target doses.