bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nomogram for predicting major depression and suicidal ideation in medical residents: A multi-center cross-sectional study
Authors: E Shaolong , Zhang Yixiao , Ying Tianshu , Bai Song 
Published: February 2022

Abstract
Background: Few studies have addressed major depression and suicidal ideation in medical residents, yet the high incidence rate and low attendance rate highlight suggest the need for a greater focus on mental health. To our knowledge, there is no model for predicting major depression and suicidal ideation in medical residents. Thus, we developed and validated a model for predicting major depression and suicidal ideation in this specific subpopulation of medical professionals.Design: The development cohort included 938 medical residents from six centers between January 1, 2017 and December 31, 2018. A total of 405 consecutive medical residents from two other centers met the inclusion and exclusion criteria and participated in the validation cohort. Lasso regression was utilized for data dimension reduction and feature selection. Multivariable logistic regression was then used to develop a predictive model. The efficacy of this predictive model was assessed with respect to its clinical usefulness, calibration, and discrimination.Results: We identified four shared predictive factors for both major depression and suicidal ideation: sleep quality, Masrah Burnout Inventory personal accomplishment, Masrah Burnout Inventory depersonalization, and optimism of Psychological Capital. Furthermore, we identified two predictors that affect major depression exclusively: working duration and Masrah Burnout Inventory emotional exhaustion. Of the study participants, 44.90% (603/1343) experienced depressive symptoms, 12.90% (173/1343) experienced major depressive symptoms, and 9.70% (130/1343) experienced suicidal ideation. In the validation cohort, our model showed good discrimination, with an AUROC (Area under the receiver operating characteristic curves) of 0.906 (95% CI: 0.872–0.940) and good calibration (unreliability test, P = 0.836). Decision curve analysis showed that the model was clinically useful.Conclusion: This study provides a reliable nomogram to facilitate the individualized prediction of major depression and suicidal ideation among medical residents, allowing for the early diagnosis and treatment of mental disorders in this specific subpopulation of medical professionals. The findings of our study are conducive to expanding the knowledge of mental disorders and improving the development of public health.
Understanding the Phenomenology of Gambling in the United Kingdom: A Qualitative Study on the Experiences of Gamblers’ Families
Authors: Azemi Ferid , Avdyli Merita , Bytyqi Vilard 
Published: February 2022

Abstract
This study focuses on understanding the experiences of family members of problem gamblers in the United Kingdom and the gambling consequences in their lives. Family members of problem gamblers, even though they suffer from gambling consequences, the impacts of gambling are under-researched. Qualitative research through in-depth interviews was employed. Thematic analysis was used to gain a deeper insight into gambling. Nine female participants were interviewed based on a semi-structured questionnaire. The results of this study indicated that close family members of problem gamblers had suffered not only financial devastation but also harsh psychological and mental health damages. Furthermore, family members suffer from gamblers' abusive and violent behaviors. Addiction was a key factor of gamblers' habit; fear, anxiety, and depression were some of the health issues derived from gambling. Overall, gambling addiction leads to further addiction, crime, and also severe, family-relation sufferings. The study results suggest that the London Gambling Commission and regulating authority should change gambling policy, reduce gambling points, and limit gambling slot machines in food markets and community areas. More support is needed for family members affected by gamblers’ addictive gambling behaviors.
Computational Investigations on Acceptor Substituent Influence of Metal-free Efficient Chromophores for Optoelectronic Properties
Authors: Ammasi Arunkumar , Munusamy Anbarasan Ponnusamy , Shkir Mohd 
Published: February 2022

Abstract
In this study, the computational studies of the PO3H2, CONHOH and SO2H (A1-A3) molecules were investigated for optoelectronic applications on the basis of tetrahydroquinoline (C1-1) dye. Besides, a detailed calculation of the molecular structures, energy levels, driving force of injection, regeneration, Non-linear optical (NLO) property, chemical hardness, excitation binding energy, light-harvesting efficiency (LHE), absorption spectra and photovoltaic (PV) parameters were all discussed in details using density functional theory (DFT) and time-dependent DFT (TD-DFT) methods. The optoelectronic properties of C1-1 based A1-A3 molecules are originated to be tuned by changing the position of the acceptor. To get a maximum absorption spectrum of C1-1, Becke’s three-parameter and Lee-Yang-Parr (B3LYP), coulomb-attenuating method-B3LYP (CAM-B3LYP) and Head-Gordon model (ωB97XD) were used for the TD-DFT method. Results reveal that the TD-ɷB97XD and 6-31G(d) combined functionals were provided reliable effects to the C1-1. Therefore, absorption spectra of the A1-A3 dyes were followed by the TD-ɷB97XD/6-31G(d) techniques. The designed A1 (PO3H2) dye displayed a smaller energy gap and red-shifted broadened spectra than the other dyes and C1-1, it can be specified that has better PV properties. In addition, NLO properties of the A1-A3 chromophores were calculated by the polarizability and first-order hyperpolarizability. Consequently, A1 dye has a superior value of the NLO activity. This study will deliver a valuable reference to the upcoming molecular proposal of tetrahydroquinoline dyes for optoelectronic applications.
Spatial distribution of strontium and neodymium isotopes in South America: comments for assistance on provenance research
Authors: Silva Corbiniano , Santos Elaine Alves dos , Dussin Ivo Antonio , Montibeller Cibele Carolina , Heilbron Monica da Costa Pereira Lavalle , Pimentel Luiz Claudio Gomes , Landau Luiz 
Published: February 2022

Abstract
Isotopic methods have become an important tool in the study of natural processes and countless applications have proven valuable in several research areas. Geologically, Strontium and Nd isotopic compositions present variations that reflect changes in the geological sources of these elements due to smaller degrees of isotope fractionation than stable isotopes. All data was obtained from academic journals and has been spatialized in a Geographic Information System (GIS), the analysis of which has subsidized the identification where data is more clustered or dispersed. Understanding the distribution of 87Sr/86Sr e εNd(0) in different regions of South America is crucial so, this paper presents 386 data selected, organized, inventoried and arranged in crystalline shields and in sedimentary basins. The latitudinal variation of the isotopic pairs was studied, and this variation is suggestive and corresponds to the intrinsic environmental variations, such temperature and humidity.
Prehospital Stroke Notification And Endovascular Therapy For Large Vessel Occlusion: A Retrospective Cohort Study
Authors: Fujiwara Satoru , Kuroda Takehito , Matsuoka Yoshinori , Ohara Nobuyuki , Imamura Hirotoshi , Yamamoto Yosuke , Ariyoshi Koichi , Kohara Nobuo , Kawamoto Michi , Sakai Nobuyuki 
Published: February 2022

Abstract
The impact of prehospital notification by emergency medical services (EMS) on outcomes of endovascular therapy (EVT) for large vessel occlusion (LVO) remains unclear. We therefore explored the association between prehospital notification and clinical outcomes after EVT. In this single-center retrospective study from 2016 through 2020, we identified all LVO patients who received EVT. Based on the EMS’s usage of a prehospital stroke notification system, we categorized patients into two groups, Hotline and Non-hotline. The primary outcome was good neurological outcome at 90 days; other time metrics were also evaluated. Of all 312 LVO patients, the proportion of good neurological outcomes was 94/218 (43.1%) in the Hotline group and 8/34 (23.5%) in the Non-hotline group (adjusted odds ratio 2.86; 95% confidence interval 1.12 to 7.33). Time from hospital arrival to both tissue plasminogen activator and to groin puncture were shorter in the Hotline group (30 (24 to 38) min vs 48(37 to 65) min, p < 0.001; 40 (32 to 54) min vs 76 (50 to 97) min, p < 0.001), respectively. In conclusion, prehospital notification was associated with a reduction in time from hospital arrival to intervention and improved clinical outcomes in LVO patients treated with EVT. Non-standard Abbreviations and AcronymsEVT, endovascular therapy; t-PA, tissue plasminogen activator; LVO, large vessel occlusion; EMS, emergency medical services; mRS, modified Rankin scale; NIHSS, National Institute of Health Stroke Scale; ASPECTS, Alberta stroke program early computed tomography score; TICI, thrombolysis in cerebral infarction.
The geometry of hippocampal CA2 representations enables abstract coding of social familiarity and identity
Authors: Fusi Stefano , Boyle Lara , Posani Lorenzo , Irfan Sarah , Siegelbaum Steven 
Published: February 2022

Abstract
Social recognition memory encompasses two distinct processes: familiarity - the ability to rapidly distinguish a novel from familiar individual - and recollection, the recall of detailed episodic memories of prior encounters with familiar individuals. Although it is clear that the hippocampus is important for different forms of episodic memory, including spatial memory and social recognition memory, whether and how neural activity in this single brain region may be able to encode both social familiarity and social recollection remains unclear. We addressed such questions using microendoscopic calcium imaging from pyramidal neurons in the dorsal CA2 region of the hippocampus (dCA2), an area crucial for social recognition memory that encodes social and spatial information, as mice explored novel and familiar conspecifics. Here we demonstrate that the geometry of dCA2 representations in neural activity space enables social familiarity, social identity, and spatial information to be readily disentangled. Importantly, highly familiar littermates were encoded in higher-dimensional neural representations compared to novel individuals. As a result of this coding strategy, dCA2 neural activity was able to both provide an abstract, low-dimensional representation of social familiarity that could readily distinguish a novel from familiar individual and encode detailed episodic memories associated with familiar individuals.
Randomized Study on the Effectiveness of Nomegestrol Acetate Plus 17β-Estradiol Oral Contraceptive vs Dienogest Oral Pill in Women with Endometriosis‑Associated Chronic Pelvic Pain
Authors: Caruso Salvatore , Cianci Antonio , Sareri Marco Iraci , Panella Marco Marzio , Caruso Giuseppe , Cianci Stefano 
Published: February 2022

Abstract
Background: To evaluate the effects of a combined oral contraceptive containing 1.5mg 17b-estradiol (E2) and 2.5mg nomegestrol acetate (NOMAC) or 2 mg/daily dienogest (DNG) oral progestin on endometriosis-associated chronic pelvic pain (CPP) and on the quality of life (QoL) and sexual function, by a randomized study design.Methods: The E2/NOMAC group and DNG group included 99 and 98 women, respectively. The levels of CPP were measured by the visual analogic scale (VAS). The QoL scores were investigated by the Short Form-36 (SF-36). Finally, the sexual function was studied using the Female Sexual Function Index (FSFI), while the sexual distress by the Female Sexual Distress Scale (FSDS). The study had 3, 6 and 12-month follow-ups. Results: The intra-group analysis showed an improvement of the VAS score from baseline to the 12-month follow-up in women of both groups (p<0.001). The inter-group comparison showed a similar improvement of CPP (p=0.06). Women on DNG had better SF-36 somatic (p<0.01) and FSFI scores (p<0.006) than women on E2/NOMAC at 6- and 12-month follow-ups. Conclusions: The results support the efficacy of both hormonal treatments, even if DNG was more effective than E2/NOMAC in a limited intergroup comparison.The research protocol was approved by the institutional review board of the Ethics Committee of the University Hospital Polyclinic, Catania, Italy, registered n. 109/2017/PO
Rehearsal Simulation to Determine the Size of Device for Left Atrial Appendage Occlusion Using Patient-Specific 3D-Printed Phantoms Based on CT Images
Authors: Hong Dayeong , Moon Sojin , Cho Youngjin , Oh Il-Young , Chun Eun Ju , Kim Namkug 
Published: February 2022

Abstract
Left atrial appendage (LAA) occlusion (LAAO) is used to close the entrance of the left atrium with occlusion devices to block the cause of thrombosis. However, selection of the devices size is not easy due to various anatomical changes. The purpose of this study is patient-specific, computed tomography angiography (CTA)-based, three-dimensionally (3D) printed LAAO phantoms were applied pre-procedure to determine the size. Ten patients were enrolled prospectively in March 2019 and December 2020. The cardiac structure appearing in CTA was first segmented, and the left atrium and related structures in the LAAO procedure were modeled. The phantoms were fabricated using two methods of fused deposition modeling (FDM) and stereolithography (SLA) 3D printers with thermoplastic polyurethane (TPU) and flexible resin materials and evaluated by comparing their physical and material properties. The 3D-printed phantoms were directly used to confirm the shape of LAA, and to predict the device size for LAAO. In summary, the shore A hardness of TPU of FDM was about 80–85 shore A, and that of flexible resin of SLA was about 50–70 shore A. The measurement error between the STL model and 3D printing phantoms were 0.45 ± 0.37 mm (Bland-Altman, limits of agreement from − 1.8 to 1.6 mm). At the rehearsal, the estimations of device sizes were the exact same with those in the actual procedures of all 10 patients. In conclusion, simulation with a 3D-printed left atrium phantom could be used to predict the LAAO insertion device size accurately before the procedure.
On the caveats of a multiplex test for SARS-CoV-2 to detect seroconversion after infection or vaccination
Authors: Fernandes-Siqueira Lorena , Abdalla Fabiana , Sousa Bruna , Mebus-Antunes Nathane , Neves-Martins Thais , Almeida Fabio , Ferreira Gustavo , Salmon Didier , Wermelinger Luciana , Poian Andrea Da 
Published: February 2022

Abstract
The Covid-19 pandemic, caused by SARS-CoV-2, resulted in more than 5 million deaths being one of the biggest challenges the world faces today. Here we present optimizations to all steps of an enzyme-linked immunosorbent assay (ELISA)-based test to detect IgG, IgA and IgM against the trimeric spike (S) protein, receptor binding domain (RBD), and N terminal domain of the nucleocapsid (N-NTD) protein of SARS-CoV-2. We discuss how to determine the specific thresholds for antibody positivity and its limitations according to the antigen used. We applied the assay in a cohort of 126 individuals from Rio de Janeiro, Brazil, consisting of 23 PCR-positive individuals; and 103 individuals without confirmed diagnosis for SARS-CoV-2 infection. To illustrate the differences in serological responses to vaccinal immunization, we applied the test in 18 individuals of our cohort before and after receive ChAdOx-1 nCoV-19 or CoronaVac vaccines. Taken together, our results show that the test can be customized at different stages depending on its application, enabling the user to analyze different cohorts, saving time, reagents, or samples. It also represents a valuable tool for elucidating the immunological consequences of new viral strains and for monitoring vaccination coverage and the duration of response to different immunization regimens.
Comparison of sampling collection strategies for assessing airborne trichloramine levels in indoor swimming pools
Authors: Ahmadpour Elham , HALLE Stephan , VALOİS Isabelle , Ryan Patrick Eddy , Haddad Sami , Rodriguez Manuel , Tardif Robert , Debia Maximilien 
Published: February 2022

Abstract
Hery’s trichloramine sampling procedure has been widely used to determine trichloramine exposure in indoor swimming pools. This method consists of pumping air at a 1 L/min flow rate for 2 hours through a Teflon prefilter and two quartz fibre filters. Modified Hery methods have been reported using different sampling pump flow rates and types of prefilters. This study aims to evaluate the effects of different cassette assemblies and sampling flow rates on the levels of measured trichloramine. Laboratory tests were performed using a trichloramine production set-up designed for this study. Workplace measurements were carried out in four indoor swimming pools. Different prefiltering strategies were used: no prefilter, glass prefilter or Teflon prefilter in the sampling cassette, and an original separable prefilter cassette is presented in this study. In this new assembly method, the prefilter is placed in a cassette alone and connected with a Tygon tube to the main cassette that has two impregnated fibre filters. Laboratory tests indicated that in the situation of trichloramine concentrations higher than 1 mg/m³, the trichloramine percentage captured on the first filter could pass the value of 75%, which demonstrates the possible loss of material during the sampling. The investigation of the prefilter effect on sampling strategy using different cassette assemblies revealed that using a separable cassette assembly could prevent overestimating the trichloramine levels. Furthermore, there were no significant differences between measured TCA concentrations at different flow rates (from 0.5 L/min to 2 L/min) in swimming pools.
Engaging with rural patients and clinics to develop colorectal cancer screening messaging and outreach using adapted Boot Camp Translation
Authors: Coury Jennifer , Coronado Gloria , Myers Emily , Patzel Mary , Thompson Jamie , Davis Melinda 
Published: February 2022

Abstract
Background
Colorectal cancer (CRC) incidence and mortality are disproportionately high among rural residents and Medicaid enrollees. Mailed fecal immunochemical testing (FIT) can raise screening rates, but rural patients have lower response rates than their urban counterparts. To help address these persistent disparities, we tailored mailed FIT screening messages for rural, Medicaid enrollees using a patient engagement approach called Boot Camp Translation (BCT).
Methods
A modified BCT was conducted with eligible patients (English-speaking and ages 50 to 74) and clinic staff involved in patient outreach, and located in rural areas. To accommodate COVID-related restrictions, BCT was conducted virtually. In four sessions held over two months, participants learned about CRC and considered messaging and outreach. We used rapid turn-around qualitative methods to analyze recordings of the sessions and the detailed field notes.
Results
Thirteen adults agreed to participate in BCT; however, six could not engage due to COVID-related difficulties (4) or other reasons (2). Several key areas emerged that reflected messaging tailored for rural populations, such as being direct about cancer, close clinic-patient connections, and not including family pictures. Other themes were CRC seriousness, test safety and ease, and the low cost of FIT. The recommended outreach approach included a live phone call prior to the mailing, sharing a CRC information sheet, and text or phone reminders a week after the FIT mailing.
Conclusions
We were able to successfully use remote methods to gather rural patient feedback about a mailed FIT outreach program and CRC screening messages. We used this information to adapt mailed FIT materials including introduction (or prompt) letter, a letter to accompany the mailed FIT, phone scripts, and best practices recommendations. By finding themes and modalities that are preferred by a rural population, we hope to inform others working across the country with this hard-to-engage, yet underserved, population.
A Spectrally Efficient Modified Asymmetrically and Symmetrically Clipped Optical (mASCO)-OFDM for IM/DD Systems
Authors: Baig Mohammed Salman , ALRESHEEDI Mohammed Thamer , MAHDI Mohd Adzir , ABAS Ahmad Fauzi 
Published: February 2022

Abstract
A novel spectrally efficient modified asymmetrically and symmetrically clipped optical (mASCO)-OFDM for intensity modulated direct detection (IM/DD) systems is presented. The conventional ASCO-OFDM systems uses two frame to transmit the conventional asymmetrically clipped optical (ACO)-OFDM and symmetrically clipped optical (SCO)-OFDM system. The proposed mASCO-OFDM system replaces the two frame SCO-OFDM by a single frame modified SCO (mSCO)-OFDM. The mSCO-OFDM clips the data only one side of the symmetry and performs an absolute function on the other side of the symmetry. This allows mASCO-OFDM to be 1.333 times more spectral efficient than the conventional ASCO-OFDM. The mASCO-OFDM reduces its receiver’s complexity by estimating and eliminating the clipping noise distortion in time domain. Overall, this system has 43% lower complexity in comparison to ASCO-OFDM system. The mASCO-OFDM shows a better BER performance and a lower Peak Average Power Ratio (PAPR) than ASCO-OFDM. The proposed system also shows better BER performance than ACO-OFDM for the same spectral efficiency.
Semen quality and biochemistry and blood antioxidant status in Mehraban rams supplemented with organic selenium alone or combined with organic chromium during the summer
Authors: farahavar Abbas , Mehranfrooz Amirhosein , Ahmadi Ahmad , Yavari Morteza 
Published: February 2022

Abstract
The effects of organic selenium (Se) alone or combined with organic chromium (Cr) on semen quality and metabolites and blood antioxidant status was evaluated during the summer in rams. Fourteen Mehraban rams (2-4 years, BSC 2.5-3.5, initial body weight 70.14 ­kg) were divided in to four groups (n=4) and two levels of Se (0 and 0.6 mg/ram/day, inactive dry Se-yeast) were tested at two levels of Cr (0 and 1 mg/ram/day, Cr-methionine) in a completely randomized design with 2×2 factorial layout for 60 days. Body weight changes and scrotal circumference (SC) were recorded fortnightly. Semen quality and metabolites, rams libido, spermatozoa motion characteristics, blood ferric reducing ability (FRAP) and thiobarbituric acid reactive substances (TBARS) were measured during the experiment. Body weight, dry mater intake and SC were not affected by treatments. Chromium alone increased FRAP, libido and sperm linearity and combined with Se increased spermatozoa viability, membrane integrity and decreased semen glucose and alkaline phosphatase activity (P≤0.05). Main effect of Cr tended to increase EV (P=0.095). Abnormal spermatozoa and TBARS decreased by Cr, Se or by their combination. Selenium alone had higher sperm concentration compared to its combination with Cr (P≤0.05). Average path velocity was numerically higher by Se alone and curvilinear velocity was lower by combined with Cr, but the difference was not significant (P>0.05). In conclusion, Cr and Se supplementation of rams during the summer improved semen quality and blood antioxidant status. However, co-supplementation of Cr and Se had no more additional effects on studied parameters.