bluuebunny/crossref_metadata_2025_split huggingface dataset:
The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division
Authors: Hurtig Fredrik , Burgers Thomas C.Q. , Cezanne Alice , Jiang Xiuyun , Mol Frank Nico , Traparić Jovan , Tarrason-Risa Gabriel , Pulschen Andre Arashiro , Harker-Kirschneck Lena , Šarić Anđela , Vlijm Rifka , Baum Buzz 
Published: September 2022

AbstractESCRT-III family proteins form composite polymers that deform and cut membrane tubes in the context of a wide range of cell biological processes across the tree of life. In reconstituted systems sequential changes in the composition of ESCRT-III polymers induced by the AAA ATPase Vps4 have been shown to remodel membranes. However, it is not known how composite ESCRT-III polymers are organised and remodelled in space and time in cells. Here, taking advantage of the relative simplicity of the ESCRT-III-dependent division system in Sulfolobus acidocaldarius, one of the closest experimentally tractable prokaryotic relative of eukaryotes, we use super-resolution microscopy and computational modelling to show how CdvB/CdvB1/CdvB2 proteins form a precisely patterned composite ESCRT-III division ring which undergoes stepwise Vps4-dependent disassembly and contracts to cut cells into two. These observations lead us to suggest sequential changes in a patterned composite polymer as a general mechanism of ESCRT-III-dependent membrane remodelling.
Performance implications of peer monitoring among suppliers
Authors: Hu Qinfang , Hu Jing , Yang Zhilin 
Published: September 2022

PurposeWhat are the performance implications of peer monitoring in a multiple-supplier context? Grounded in agency and social exchange theories, this study aims to examine how, when, and why peer monitoring works as a crucial control mechanism to reduce opportunism among suppliers.Design/methodology/approachA conceptual model and research hypotheses are tested using survey data from 246 respondents in 82 supplier groups.FindingsResults suggest that peer monitoring is related positively to perceived deterrence (as mediator) and negatively to opportunism, whereas the mediated relationship is moderated negatively by generalized reciprocity and positively by balanced reciprocity and negative reciprocity.Originality/valueThis study introduces the application of peer monitoring into business-to-business research and shows how it reduces opportunism. Its findings have implications for manufacturers on how to use peer monitoring to control opportunism among multiple suppliers.
Reflective and composite scales in tourism and hospitality research: revising the scale development procedure
Authors: Rasoolimanesh S. Mostafa , Ali Faizan , Mikulić Josip , Dogan Seden 
Published: September 2022

Purpose
The purpose of this paper is to critically review and synthesize the scale development practices in hospitality and tourism and propose updated guidelines applicable for both reflective and composite scales.

Design/methodology/approach
Using a critical review of a sample of scale development papers published in six top-tier tourism and hospitality journals, the current guidelines' weaknesses and strengths and their applications are identified. Updated procedures are proposed to overcome these weaknesses.

Findings
This review showed several issues in applying existing guidelines, including incomplete and unclear data collection processes, inconsistent data analysis processes including validity/reliability assessment and lack of criteria to identify and assess composite scales. As such, this paper proposes updated guidelines by incorporating the confirmatory composite analysis to assess composite scales.

Originality/value
This paper offers unique theoretical and methodological contributions to scale development literature, by identifying the shortcomings of current practices of scale development and propose guidelines for both reflective and composite scales. The current scale development procedures cannot be applied for composite scales, and so the results of composite scale development using the current procedures are questionable. The updated guidelines by the current study improve new scales' accuracy, reliability and validity.
Teaching a Lean masterclass in the metaverse
Authors: Hines Peter , Netland Torbjørn H. 
Published: September 2022

Purpose
This paper reports exploratory findings about teaching in the metaverse using a virtual reality (VR) platform and head-mounted displays. This paper addresses three research questions: Is the metaverse an appropriate platform for teaching Lean? What are the benefits and problems of this approach over traditional classroom methods? What are the future implications for teaching Lean in the VR-enabled metaverse?

Design/methodology/approach
The research presented in this paper is exploratory. A critical realism approach is adopted using action research through the preparation, delivery and review of the first four masterclasses entitled Leading Intelligent Lean offered by Gemba (formerly The Leadership Network). The data collection methods included a pre-workshop questionnaire, participant observation, focus groups and end-of-course surveys.

Findings
It was found that Lean can be taught successfully in the metaverse. There are many related benefits, particularly in terms of the high levels of immersion and the “wow” factor. Remaining technological limitations are reduced by continually improving the metaverse platform and the course content and delivery. The authors conclude that the metaverse is a useful addition to teaching Lean – and is especially promising when used in a blended teaching approach.

Originality/value
To the best of the authors’ knowledge, this is the first report of teaching Lean in a VR-enabled metaverse and one of the first of teaching and learning in the metaverse regardless of topic. The respective problems and benefits of this approach versus teaching in a traditional classroom setting are discussed.
Authentic leadership and employee voice behavior: the effect of Chinese employees' Zhongyong thinking
Authors: Kim Sunhyuk , Noh Grimm , Miao Siyu 
Published: September 2022

PurposeEmployee voice behavior is an important source of corporate competitiveness but employees often face difficulties in voicing their opinions. This research analyzes how authentic leadership may increase psychological safety perceived by employees, consequently encouraging employees to actively share their ideas. In addition, the authors explore the unique concept of Zhongyong thinking, a way of thinking that is common in cultures rooted in Confucianism. The authors analyze how Zhongyong thinking may affect the relationship between psychological safety and employee voice behavior.Design/methodology/approachFor the empirical analysis of authentic leadership and employee voice behavior in the Chinese context, the authors distributed surveys to employees working in various different industries in various provinces in China. The authors distributed 250 surveys in total and 213 surveys were used for analyses.FindingsThe authors' empirical analyzes illustrate that authentic leadership increases employee voice behavior, partially mediated by psychological safety. The authors also analyzed how psychological safety's effect on employee voice behavior could be moderated by Zhongyong thinking. The results demonstrate that the effect of psychological safety on voice behavior is weaker when employees are capable of exercising Zhongyong thinking.Originality/valueZhongyong thinking is still a relatively new concept that has not been studied thoroughly, and to the authors' knowledge, Zhongyong thinking has never been studied as a moderator in the relationship between psychological safety and employee voice behavior.
Integrated care with digital health innovation: pressing challenges
Authors: Pant Kanchan , Bhatia Meena , Pant Ranjan 
Published: September 2022

PurposeDigital health care has emerged as one of the most important means to deliver integrated care by care providers in recent years. As the use of digital health increases, there are some pressing issues such as interoperability of data across different healthcare information systems, regulatory environment and security and privacy of patient’s information which need to be discussed and addressed in order to reduce information silos and to ensure efficient and seamless use of digital health technologies. The purpose of this paper is to address these issues.Design/methodology/approachIn this paper the authors outline the key concepts of interoperability, key challenges pertaining in achieving interoperability and concepts of security and privacy in context of digital health models of integrated care.FindingsThe study suggests that standardization of digital health information systems and connecting existing systems to health network, addressing privacy and security related issues through a comprehensive but supportive regulatory environment and educating citizens and healthcare providers are some of the ways to achieve effective use of digital health in models of integrated care.Originality/valueAlthough the concepts of privacy and interoperability are not new, however, as per best of the authors’ knowledge, this is the first attempt to discuss the challenges and possible actions to meet the objective of achieving integrated care through digital innovation.
Does a Government Mandate Crowd Out Voluntary Corporate Social Responsibility? Evidence from India
Authors: RAJGOPAL SHIVARAM , TANTRI PRASANNA 
Published: September 2022

ABSTRACTThis study investigates the implementation of a Government of India mandate that requires firms to spend at least 2% of their profits on corporate social responsibility (CSR). The results show that qualifying firms that voluntarily engaged in CSR before the mandate reduce their CSR spending afterward. Despite increasing advertisement expenditure likely to offset the lost signaling value of voluntary CSR, stock prices and operating performance of former voluntary CSR spenders who qualify under the law decline. Our results suggest that regulatory intervention in CSR can both diminish its signaling value and lead to a reduction in voluntary CSR spending.
Drivers of coffee liking: Effect of physicochemical characteristics and aromatic profile on consumers’ acceptability of mono‐origin and mono‐variety coffees
Authors: Condelli Nicola , Cela Nazarena , Di Cairano Maria , Scarpa Teresa , Milella Luigi , Ascrizzi Roberta , Flamini Guido , Galgano Fernanda 
Published: September 2022

AbstractFew studies have investigated at the same time how physicochemical, volatile, and sensory characteristics affect coffee liking. The aim of this study is to evaluate the influence of geographical origin and variety on physicochemical parameters and volatile compounds composition of mono‐origin and mono‐variety coffees. Check‐all‐that‐apply (CATA) method was used with the aim of identifying the drivers of coffee liking. Moisture content, bulk density, solubility index, color parameters, and phenols and caffeine content were useful parameters for discriminating Robusta from Arabica variety, but not samples from different origins. The hierarchical cluster and principal component analyses performed on the headspace compositions showed a quite sharp ability to group the samples based on their variety. Based on CATA results, roasted attribute, related to the presence of pyrazines, was considered a positive driver of coffee liking unlike grassy and acidic attributes (associated to the presence of acids and aldehydes, respectively). Findings from this study can be a useful tool for coffee manufacturers for a winning market strategy, helping them in the choice of the most suitable raw materials and process conditions in order to produce a well‐balanced beverage by enhancing all the possible positive drivers of acceptability and reducing the negative ones.
Did the PCAOB's 2009 Office Expansion Improve Audit Quality?*
Authors: Blann James J. , Kleppe Tyler J. , Shipman Jonathan E. 
Published: September 2022

ABSTRACTWe investigate whether the PCAOB's decision to expand the number and location of its inspection offices in 2009 improved the reliability of US audits. We use a difference‐in‐differences empirical design to consider the impacts of the expansion on audit quality and find that audit quality significantly improved following the PCAOB's expansion in markets where new offices opened relative to markets without an office opening. We find that the improvement in audit quality appears to be driven by auditors' reaction to real changes in PCAOB oversight and that triennially inspected auditors appear to be impacted the most by this office expansion. Our findings provide new insights into the PCAOB's operational decision‐making and suggest that the regulator's additional investment in audit oversight was effective in improving audit quality.
Saxagliptin alleviates erectile dysfunction through increasing stromal cell‐derived factor‐1 in diabetes mellitus
Authors: Sun Taotao , Xu Wenchao , Wang Jiaxin , Wang Tao , Wang Shaogang , Liu Kang , Liu Jihong 
Published: September 2022

AbstractBackgroundDiabetes mellitus‐induced erectile dysfunction (DMED) is one of the complications of diabetes and has a poor response to phosphodiesterase type 5 inhibitor, the first‐line treatment for ED. Saxagliptin (Sax), a dipeptidyl peptidase‐4 inhibitor (DPP‐4i), has been officially used in the treatment of type 2 diabetes. Stromal cell‐derived factor‐1 (SDF‐1) is one of the important substrates of DPP‐4, and has been proven to be beneficial for several DM complications. However, it is unknown whether Sax contributes to the management of DMED.ObjectivesTo explore the effect and possible underlying mechanisms of Sax in the treatment of DMED.MethodsThe model of DM was established by intraperitoneal injection of streptozotocin. All rats were divided into three groups (n = 8 per group): control group, DMED group and DMED+Sax group. In cellular experiments, the corpus cavernosum smooth muscle cells (CCSMCs) were exposed to high glucose (HG), and treated with Sax and AMD3100 (SDF‐1 receptor inhibitor). The penile tissue and CCSMCs were harvested for detection.ResultsWe found that erectile function was impaired in DMED rats compared with the control group, which was partially relieved by Sax. Decreased expression of DPP‐4 and increased level of SDF‐1 were also observed in DMED+Sax group, together with elevation of PI3K/AKT pathway and inhibition of endothelial dysfunction, oxidative stress and apoptosis in corpus cavernosum. Moreover, Sax could also regulate oxidative stress and apoptosis in CCSMCs under HG condition, which was blocked in part by AMD3100.ConclusionSax could alleviate DMED through increasing SDF‐1 and PI3K/AKT pathway, in company with moderation of endothelial dysfunction, oxidative stress and apoptosis. Our findings indicated that DPP‐4 is may be beneficial to the management of DMED.
Daratumumab plus lenalidomide, bortezomib and dexamethasone in newly diagnosed multiple myeloma: Analysis of vascular thrombotic events in the GRIFFIN study
Authors: Sborov Douglas W. , Baljevic Muhamed , Reeves Brandi , Laubach Jacob , Efebera Yvonne A. , Rodriguez Cesar , Costa Luciano J. , Chari Ajai , Silbermann Rebecca , Holstein Sarah A. , Anderson Larry D. , Kaufman Jonathan L. , Shah Nina , Pei Huiling , Patel Sharmila , Cortoos Annelore , Bartlett J. Blake , Vermeulen Jessica , Lin Thomas S. , Voorhees Peter M. , Richardson Paul G. 
Published: September 2022

SummaryPatients with multiple myeloma are at increased risk of vascular thromboembolic events (VTEs). This post hoc analysis evaluated VTEs in the randomised phase 2 GRIFFIN study (ClinicalTrials.gov Identifier: NCT02874742) that investigated lenalidomide/bortezomib/dexamethasone (RVd) ± daratumumab (D). Patients with newly diagnosed multiple myeloma who were eligible for autologous stem cell transplantation (ASCT) received D‐RVd/RVd induction, high‐dose therapy and ASCT, D‐RVd/RVd consolidation and up to 2 years of lenalidomide maintenance therapy ± D. VTE prophylaxis was recommended (at least aspirin, ≥162 mg daily) in accordance with International Myeloma Working Group guidelines. In the safety population (D‐RVd, n = 99; RVd, n = 102), VTEs occurred in 10.1% of D‐RVd patients and 15.7% of RVd patients; grade 2–4 VTEs occurred in 9.1% and 14.7%, respectively. Median time to the first onset of VTE was longer for D‐RVd versus RVd patients (305 days vs 119 days). Anti‐thrombosis prophylaxis use was similar between arms (D‐RVd, 84.8% vs RVd, 83.3%); among patients with VTEs, prophylaxis use at time of first VTE onset was 60.0% for D‐RVd and 68.8% for RVd. In summary, the addition of daratumumab to RVd did not increase the incidence of VTEs, but the cumulative VTE incidence was relatively high in this cohort and anti‐thrombotic prophylaxis use was suboptimal.
Socio‐cognitive, expertise‐based and appearance‐based accounts of the other‐‘race’ effect in face perception: A label‐based systematic review of neuroimaging results
Authors: Ficco Linda , Müller Veronika I. , Kaufmann Jürgen M. , Schweinberger Stefan R. 
Published: September 2022

AbstractTwo competing theories explain the other‐‘race’ effect (ORE) either by greater perceptual expertise to same‐‘race’ (SR) faces or by social categorization of other‐‘race’ (OR) faces at the expense of individuation. To assess expertise and categorization contributions to the ORE, a promising—yet overlooked—approach is comparing activations for different other‐‘races’. We present a label‐based systematic review of neuroimaging studies reporting increased activity in response to OR faces (African, Caucasian, or Asian) when compared with the SR of participants. Hypothetically, while common activations would reflect general aspects of OR perception, ‘race’‐preferential ones would represent effects of ‘race’‐specific visual appearance. We find that several studies report activation of occipito‐temporal and midcingulate areas in response to faces across different other‐‘races’, presumably due to high demand on the visual system and category processing. Another area reported in response to all OR faces, the caudate nucleus, suggests the involvement of socio‐affective processes and behavioural regulation. Overall, our results support hybrid models—both expertise and social categorization contribute to the ORE, but they provide little evidence for reduced motivation to process OR faces. Additionally, we identify areas preferentially responding to specific OR faces, reflecting effects of visual appearance.
‘It's rewarding because I get the love’: Grandparents raising grandchildren with foetal alcohol spectrum disorder
Authors: Clement Alexandra L. , Harding Kelly D. , Watson Shelley L. 
Published: September 2022

AbstractThe aim of this study was to explore the lived experiences of grandparents raising their grandchildren with foetal alcohol spectrum disorder (FASD). Specifically, we sought to identify how caregivers make meaning of their experience, what challenges are faced by grandparents while raising a second generation and what positive experiences are encountered. Ten grandparents raising a child with FASD in Ontario, Canada, participated in semi‐structured interviews. Interpretative phenomenological analysis was used to analyse the interviews to determine reoccurring themes. Three main themes were identified: (i) challenges when raising a grandchild with FASD, including kinship adoption struggles and intergenerational issues; (ii) worries about the future, including financial planning and health concerns; and (iii) rewards, such as shifts in priorities and the opportunity to raise a second generation. Grandparents raising their grandchildren with FASD face challenges and thus require specific supports so that they may adequately provide a safe and nurturing home environment for children with often challenging learning and social needs.
Risk of genetic and epigenetic alteration in children conceived following ART: Is it time to return to nature whenever possible?
Authors: Sciorio Romualdo , Tramontano Luca , Rapalini Erika , Bellaminutti Serena , Bulletti Francesco M. , D'Amato Antonio , Manna Claudio , Palagiano Antonio , Bulletti Carlo , Esteves Sandro C. 
Published: September 2022

AbstractAssisted reproductive technology may influence epigenetic signature as the procedures coincide with the extensive epigenetic modification occurring from fertilization to embryo implantation. However, it is still unclear to what extent ART alters the embryo epigenome. In vivo fertilization occurs in the fallopian tube, where a specific and natural environment enables the embryo's healthy development. During this dynamic period, major waves of epigenetic reprogramming, crucial for the normal fate of the embryo, take place. Over the past decade, concerns relating to the raised incidence of epigenetic anomalies and imprinting following ART have been raised by several authors. Epigenetic reprogramming is particularly susceptible to environmental conditions during the periconceptional period; therefore, unphysiological conditions, including ovarian stimulation, in vitro fertilization, embryo culture, cryopreservation of gametes and embryos, parental lifestyle, and underlying infertility, have the potential to contribute to epigenetic dysregulation independently or collectively. This review critically appraises the evidence relating to the association between ART and genetic and epigenetic modifications that may be transmitted to the offspring.
Blinded by the bright: How species‐poor habitats contribute to regional biodiversity across a tropical seascape
Authors: Harper Leah M. , Lefcheck Jonathan S. , Whippo Ross , Jones M. Scott , Foltz Zachary , Duffy J. Emmett 
Published: September 2022

AbstractAimConservation efforts have traditionally addressed the threat of biodiversity loss by prioritizing regions and habitats with high endemic species richness. However, species‐poor habitats often harbour distinct, valuable and/or functionally unique species that contribute to regional diversity. In the tropical marine realm, the ‘mangrove‐seagrass‐coral reef continuum’ has dominated both the scientific literature and marine spatial planning. Bare sediment habitats are also part of this continuum and often comprise the majority of bottom area, as they do in most regions worldwide, but are understudied and rarely considered in conservation. To address this information gap, we partition the relative contributions of five habitats in the coastal mosaic (forereefs, patch reefs, seagrass, mangroves and bare sand) to fish diversity across a tropical seascape.LocationCarrie Bow Cay, Belize Barrier Reef.MethodsUsing diver visual censuses, we assessed fish community composition at three replicate sites from each of the five habitats annually for 5 years. We then partitioned diversity into within (α) and between (β) habitat contributions, and further partitioned β‐diversity into components attributed to species replacement and richness difference. Finally, we determined the local contributions to β‐diversity (LCBD) by each habitat and identified the key individual species behind these contributions.Main ResultsTropical sand flats contributed uniquely and disproportionately to regional fish species diversity, despite having the fewest species overall. Sand flats also had higher‐than‐expected local contributions to β‐diversity (LCBD) and had the highest percentage of species not found in other habitats.Main ConclusionsOur results demonstrate that previously understudied sand habitats harbour a relatively unique assemblage of species compared with other nearby habitats. Marine spatial planning aimed at maximizing the preservation of total biodiversity (including unique species) in the tropics should consider sand habitats.