bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly malignant disease in childhood-onset arrhythmogenic right ventricular cardiomyopathy
Authors: Smedsrud Marit Kristine , Chivulescu Monica , Forså Marianne Inngjerdingen , Castrini Isotta , Aabel Eivind Westrum , Rootwelt-Norberg Christine , Bogsrud Martin Prøven , Edvardsen Thor , Hasselberg Nina Eide , Früh Andreas , Haugaa Kristina Hermann 
Published: August 2022

Abstract

Aims
This study aimed to explore the incidence of severe cardiac events in paediatric arrhythmogenic right ventricular cardiomyopathy (ARVC) patients and ARVC penetrance in paediatric relatives. Furthermore, the phenotype in childhood-onset ARVC was described.

Methods
Consecutive ARVC paediatric patients and genotype positive relatives ≤18 years of age were followed with electrocardiographic, structural, and arrhythmic characteristics according to the 2010 revised Task Force Criteria. Penetrance of ARVC disease was defined as fulfilling definite ARVC criteria and severe cardiac events were defined as cardiac death, heart transplantation (HTx) or severe ventricular arrhythmias. Childhood-onset disease was defined as meeting definite ARVC criteria ≤12 years of age.

Results
Among 62 individuals [age 9.8 (5.0–14.0) years, 11 probands], 20 (32%) fulfilled definite ARVC diagnosis, of which 8 (40%) had childhood-onset disease. The incidence of severe cardiac events was 23% (n = 14) by last follow-up and half of them occurred in patients ≤12 years of age. Among the eight patients with childhood-onset disease, five had biventricular involvement needing HTx and three had severe arrhythmic events. Among the 51 relatives, 6% (n = 3) met definite ARVC criteria at time of genetic diagnosis, increasing to 18% (n = 9) at end of follow-up.

Conclusions
In a paediatric ARVC cohort, there was a high incidence of severe cardiac events and half of them occurred in children ≤12 years of age. The ARVC penetrance in genotype positive paediatric relatives was 18%. These findings of a high-malignant phenotype in childhood-onset ARVC indicate a need for ARVC family screening at younger age than currently recommended.
Empagliflozin in acute myocardial infarction: the EMMY trial
Authors: von Lewinski Dirk , Kolesnik Ewald , Tripolt Norbert J , Pferschy Peter N , Benedikt Martin , Wallner Markus , Alber Hannes , Berger Rudolf , Lichtenauer Michael , Saely Christoph H , Moertl Deddo , Auersperg Pia , Reiter Christian , Rieder Thomas , Siller-Matula Jolanta M , Gager Gloria M , Hasun Matthias , Weidinger Franz , Pieber Thomas R , Zechner Peter M , Herrmann Markus , Zirlik Andreas , Holman Rury R , Oulhaj Abderrahim , Sourij Harald 
Published: August 2022

AbstractAimsSodium–glucose co-transporter 2 inhibition reduces the risk of hospitalization for heart failure and for death in patients with symptomatic heart failure. However, trials investigating the effects of this drug class in patients following acute myocardial infarction are lacking.Methods and resultsIn this academic, multicentre, double-blind trial, patients (n = 476) with acute myocardial infarction accompanied by a large creatine kinase elevation (&gt;800 IU/L) were randomly assigned to empagliflozin 10 mg or matching placebo once daily within 72 h of percutaneous coronary intervention. The primary outcome was the N-terminal pro-hormone of brain natriuretic peptide (NT-proBNP) change over 26 weeks. Secondary outcomes included changes in echocardiographic parameters. Baseline median (interquartile range) NT-proBNP was 1294 (757–2246) pg/mL. NT-proBNP reduction was significantly greater in the empagliflozin group, compared with placebo, being 15% lower [95% confidence interval (CI) −4.4% to −23.6%] after adjusting for baseline NT-proBNP, sex, and diabetes status (P = 0.026). Absolute left-ventricular ejection fraction improvement was significantly greater (1.5%, 95% CI 0.2–2.9%, P = 0.029), mean E/e′ reduction was 6.8% (95% CI 1.3–11.3%, P = 0.015) greater, and left-ventricular end-systolic and end-diastolic volumes were lower by 7.5 mL (95% CI 3.4–11.5 mL, P = 0.0003) and 9.7 mL (95% CI 3.7–15.7 mL, P = 0.0015), respectively, in the empagliflozin group, compared with placebo. Seven patients were hospitalized for heart failure (three in the empagliflozin group). Other predefined serious adverse events were rare and did not differ significantly between groups.ConclusionIn patients with a recent myocardial infarction, empagliflozin was associated with a significantly greater NT-proBNP reduction over 26 weeks, accompanied by a significant improvement in echocardiographic functional and structural parameters.ClinicalTrials.gov registration NCT03087773.
Rate and nature of complications with leadless transcatheter pacemakers compared with transvenous pacemakers: results from an Italian multicentre large population analysis
Authors: Palmisano Pietro , Facchin Domenico , Ziacchi Matteo , Nigro Gerardo , Nicosia Antonino , Bongiorni Maria Grazia , Tomasi Luca , Rossi Andrea , De Filippo Paolo , Sgarito Giuseppe , Verlato Roberto , Di Silvestro Michele , Iacopino Saverio 
Published: August 2022

AbstractAimsThe safety and efficacy of leadless intracardiac-permanent pacemaker (L-PM) have been demonstrated in multiple clinical trials, but data on comparisons with conventional transvenous-permanent pacemaker (T-PM) collected in a consecutive, prospective fashion are limited. The aim of this analysis was to compare the rate and the nature of device-related complications between patients undergoing L-PM vs. T-PM implantation.Methods and resultsProspective, multicentre, observational project enrolling consecutive patients who underwent L-PM or T-PM implantation. The rate and nature of device-related complications were analysed and compared between the two groups. Individual 1:1 propensity matching of baseline characteristics was performed. A total of 2669 (n = 665 L-PM) patients were included and followed for a median of 39 months, L-PM patients were on average older and had more co-morbidities. The risk of device-related complications at 12 months was significantly lower in the L-PM group (0.5% vs. 1.9%, P = 0.009). Propensity matching yielded 442 matched pairs. In the matched cohort, L-PM patients trended toward having a lower risk of overall device-related complications (P = 0.129), had a similar risk of early complications (≤30 days) (P = 1.000), and had a significantly lower risk of late complications (&gt;30 days) (P = 0.031). All complications observed in L-PM group were early. Most (75.0%) of complications observed in T-PM group were lead- or pocket-related.ConclusionIn this analysis, the risk of device-related complications associated with L-PM implantation tended to be lower than that of T-PM. Specifically, the risk of early complications was similar in two types of PMs, while the risk of late complications was significantly lower for L-PM than T-PM.
Predictors of recurrence after catheter ablation and electrical cardioversion of atrial fibrillation: an umbrella review of meta-analyses
Authors: Charitakis Emmanouil , Dragioti Elena , Stratinaki Maria , Korela Dafni , Tzeis Stylianos , Almroth Henrik , Liuba Ioan , Jönsson Anders Hassel , Charalambous Georgios , Karlsson Lars O , Tsartsalis Dimitrios 
Published: August 2022

AbstractAimsThe recurrence rates after catheter ablation (CA) and direct current (DC) cardioversion remain high, although they have been established treatments of rhythm control of atrial fibrillation (AF). This umbrella review systematically appraises published meta-analyses of both observational and randomized controlled trials (RCTs) for the association of risk and protective factors for arrhythmia recurrence after CA and DC cardioversion of AF.Methods and resultsThree bibliographic databases were searched up to June 2021. Evidence of association was rated as convincing, highly suggestive, suggestive, weak, or not significant with respect to observational studies and as high, moderate, low, or very low with respect to RCTs, according to established criteria. Thirty-one meta-analyses were included. Of the 28 associations between CA and the risk of arrhythmia recurrence, none presented convincing evidence, and only the time from diagnosis to ablation over 1 year provided highly suggestive evidence. The association between hypertension and metabolic profile provided suggestive evidence. The associations of Class IC and III antiarrhythmic drugs use with the recurrence after DC cardioversion were supported by an intermediate level of evidence.ConclusionAlthough AF is a major health issue, few risk- and protective factors for AF recurrence have been identified. None of these factors examined were supported by convincing evidence, whereas established factors such as female gender and left atrial volume showed only weak association. An early CA strategy combined with treatment of metabolic syndrome and hypertension prior to CA may reduce the risk of arrhythmia recurrence. The use of antiarrhythmics can increase the success rate of DC cardioversion.Systematic review registrationPROSPERO registry number: CRD42021270613.
Contemporary management of atrial fibrillation in primary and secondary care in the UK: the prospective long-term AF-GEN-UK Registry
Authors: Shantsila Alena , Lip Gregory Y H , Lane Deirdre A 
Published: August 2022

AbstractAimsThis study established a prospective registry of contemporary management of UK patients with atrial fibrillation (AF) by cardiologists, general practitioners, and stroke, acute, and emergency medicine physicians at baseline and 1-year follow-up.Methods and resultsData on patients with recently diagnosed AF (≤12 months) were collected from medical records from 101 UK sites to permit comparison of patient characteristics and treatments between specialities. The impact of guideline-adherent oral anticoagulation (OAC) use on outcomes was assessed using Cox regression analysis. One thousand five hundred and ninety-five AF patients [mean (standard deviation) age 70.5 (11.2) years; 60.1% male; 97.4% white] were recruited in June 2017–June 2018 and followed up for 1 year. Overall OAC prescription rates were 84.2% at baseline and 87.1% at 1 year, with non-vitamin K antagonist oral anticoagulants (NOACs) predominating (74.9 and 79.2% at baseline and 1 year, respectively). Vitamin K antagonist prescription was significantly higher in primary care, with NOAC prescription higher among stroke physicians. Guideline-adherent OAC (CHA2DS2-VASc ≥2) at baseline significantly reduced risk of death and stroke at 1 year [adjusted hazard ratio (95% confidence interval): 0.48 (0.27–0.84) and 0.11 (0.02–0.48), respectively]. Rhythm control is evident in ∼25%; only 1.6% received catheter ablation.ConclusionHigh OAC use (&gt;80%, mainly NOACs) rates varied by speciality, with VKA prescription higher in primary care. Guideline-adherent OAC therapy at baseline was associated with significant reduction in death and stroke at 1 year, regardless of speciality. Rhythm-control management is evident in only one-quarter despite AF symptoms reported in 56.6%. This registry extends the knowledge of contemporary AF management outside cardiology and demonstrates good implementation of clinical guidelines for the management of AF, particularly for stroke prevention.
Costing the economic burden of prolonged sedentary behaviours in France
Authors: Noël Racine Antoine , Margaritis Irène , Duclos Martine , Carré François , Vuillemin Anne , Gautier Christèle 
Published: August 2022

Abstract

Background
There is strong evidence showing that sedentary behaviour time increase the risk to develop several chronic diseases and to premature death. The economic consequences of this risk have never been evaluated in France. The aim of this study was to estimate the economic burden of prolonged sedentary behaviour in France.

Methods
Based on individual sedentary behaviour time, relative risk to develop cardiovascular disease, colon cancer, breast cancer and all-causes of premature mortality were identified. From relative risk and prevalence of sedentary behaviour time, a population attributable fraction approach was used to estimate the yearly number of cases for each disease. Data from the National Health Insurance were used to calculate the annual average costs per case for each disease. Disease-specific and total healthcare costs attributable to prolonged sedentary behaviour time were calculated. Indirect costs from productivity loss due to morbidity and premature mortality were estimated using a friction cost approach.

Results
In France, 51 193 premature deaths/year appear related to a prolonged daily sedentary behaviour time. Each year prolonged sedentary behaviour cost 494 million € for the national health insurance. Yearly productivity loss due to premature mortality attributable to prolonged sedentary behaviour cost 507 million € and yearly productivity loss due to morbidity cost between 43 and 147 million €.

Conclusion
Significant saving and many deaths could be avoided by reducing prolonged sedentary behaviour prevalence in France. To address this issue, strong responses should be implemented to tackle sedentary behaviour, complementary to physical activity promotion.
Using systems science methods to enhance the work of national and local walking partnerships: practical insights from Ireland
Authors: Power Dylan D , Lambe Barry M , Murphy Niamh M 
Published: August 2022

Abstract

Background
Physical activity (PA) literature is dominated by individual-level descriptive studies, which are known to have limited impact on population PA levels. Leveraging systems science methods offers opportunities to approach PA in a manner which embraces its inherent complexity. This study describes how participatory systems mapping and social network analysis (SNA) were used to understand the work of local and national level walking systems in Ireland.

Methods
Two adapted participatory action research workshops with multisectoral stakeholders were used to develop a systems map for walking in Cork, Ireland. The Global Action Plan for Physical Activity 2018–2030 (GAPPA) map was used as a framework to categorize workshop outcomes. Secondly, SNA methods were used to analyse the communication network between partners of Get Ireland Walking, a national walking promotion initiative, as defined within their strategic plan and the actual communication network as experienced by the partners.

Results
The systems mapping process allowed stakeholders to identify 19 suggested actions for the Cork walking system. The SNA found that there were considerably fewer communication ties between partners in the actual communication network than in the strategy defined network.

Conclusion
The systems mapping process was a useful catalyst for engaging stakeholders in cross-sectoral communication and the GAPPA was a practical way to organize workshop outcomes. Social network analysis methods highlighted that the communication network of a national level walking promotion partnership is not working as planned. Overall, the use of systems science methods can provide practical insights for local and national level walking systems.
S01 Providing policymakers with the evidence and practices to act and improve lives through physical activity
Authors: Portas Elena , Cowen Charlie , Birdsall-Strong Lottie , Scott Chris 
Published: August 2022

Abstract
Policymakers often lack the evidence to drive change and improve the lives of citizens through physical activity. This symposium will discuss how two unique global programs, ‘Active Citizens Worldwide' (ACW) and ‘Sport Impacts: Children' (SIC), have bridged the gap between academia and policymakers. Combining advanced data analytics, the latest in health, social and economic research and global benchmarking these programs have delivered unique insights on the drivers and outcomes of physical activity.
ACW is a city-based programme formed through a collaboration of 4 cities: London, Stockholm, Singapore and Auckland. The project uses advanced analytics on large datasets covering entire cities to inform policymakers' efforts to enhance participation levels, and to calculate the monetary and non-monetary value that sport and physical activity has on society. Previously unrelated datasets have been integrated to provide completely new analytical insights on the true drivers of the complex physical activity system including facility access, and mindsets and motivations.This is combined with systematic modelling of the broad range of outputs and outcomes of physical activity including health, social, and economic benefits.This standardisation in modelling approach and analysis has enabled multiple cities to compare, benchmark and learn from each other. ACW ultimately enables cities to understand what is working and what is not in their city, and thereby design policies with the best chance of improving their city's health, wealth and wellbeing.
Using a similar approach, the SIC initiative is a unique cross-sectorial collaboration between top national sports bodies, charities and academics in England. Through this partnership each organisation shared national participation, workforce and facility databases as well as recent primary research, which was analysed and modelled to give a holistic overview of the drivers and outcomes of childhood participation in sport. This analysis shows that the access to and benefits of sport and physical activity is not equal between different demographic groups. Preliminary findings have also indicated which type of sports and activities contribute the most value to children and their communities. This has led to the creation of a strong evidence base of the social and economic impact of childhood physical activity and sport in England, which is already being used by sport bodies and policymakers to re-evaluate their approaches to childhood participation.
These programs illustrate how a collaborative approach using data and analytics has connected research with policy and practice and lead to substantial impacts in countries around the world.
Organizer and speaker: Elena Portas, Chair: Charlie Cowen,
S01-2 Providing policymakers with the evidence of the true value of physical activity to individuals and communities
Authors: Scott Chris 
Published: August 2022

Abstract

Background
With many countries and communities suffering from budget cuts, policymakers are coming under increasing pressure to provide the true value of public health interventions. Owing to the scale of conclusive findings over the past decade, we now have a robust evidence base regarding the impact of physical activity on individuals and communities. However, more work needs to be done to bridge the gap between policymakers and academics.

Methods
We conducted both a review of the leading academic research as well as primary analysis of existing open-access datasets to determine the impact of physical activity on the risk of health and social outcomes across the life course. This evidence base was then modelled with the latest figures on disease prevalence and its economic impact to quantify the social and economic value of physical activity.

Results
This methodology has currently been applied to a city population, as well as a national scale evaluation of the impact of individual sports on children alone. Results have shown that the average value of physical activity, across four cities around the world including London, Stockholm, Singapore and Auckland, is US$1900 per person in economic, health and social outcomes. In addition to this when looking specifically at the 4 million children who participate in team sports across England, preliminary findings estimate the total value to be £6.5Bn annually.

Conclusions
These initial findings are already being used by policymakers to make the case for additional investment and change the way they evaluate the outcome of their policies and programmes. For example, Aktive Auckland has secured an additional NZ$120M for sport and recreation in the 10-year annual national budget after they used results which showed the annual contribution of physical activity was $1.9Bn to the local economy. Sports federations in the UK are also reshaping their strategies towards childhood sport and activity based on the emerging findings of the report.
S02-3 Physical activity policies and good practices in Europe
Authors: Mendes Romeu , Whiting Stephen , Barbosa Ana , Duffey Keeva , Pinedo Adriana , Arnaiz Patricia , Wickramasinghe Kremlin 
Published: August 2022

Abstract

Background
The establishment of the EU physical activity (PA) guidelines and the HEPA monitoring framework has had an impact on policy development and implementation across the region from 2015. This works presents results from the third round of monitoring in 2021 and discusses trends since 2015.

Methods
A questionnaire was distributed in 2021 to all EU Member States of the WHO European Region through the network of PA Focal Points, who were requested to collect data from national colleagues and complete the questionnaire. All EU Member States (27 in 2021) responded to the survey on the implementation of the 23 indicators of the HEPA monitoring framework.

Results
The results of the 2021 round of data collection on HEPA indicators showed an overall stabilization of the implementation of PA promotion policies. Besides important increases in several indicators, such as indicators 15 (HEPA in the training of physical education teachers), 20 (Schemes to promote physical activity at the workplace) and 21 (Schemes for community interventions to promote physical activity in older adults), many others decreased and others showed no progress. Most national physical activity policies or action plans were multi-sectoral, with good coverage of the sectors recognized as important for HEPA promotion. While some methodological aspects may have affected the results, this round also reflected policy implementation during the COVID-19 pandemic (2019–2021). COVID-19 has had a significant impact on all sectors of society but especially on health, sports, education and mobility, which are major areas for PA promotion and policy implementation.

Conclusions
There seems to be an overall stabilization of the implementation of PA promotion policies since 2015. Public health experts and decision makers could utilise the increase in public awareness of the health benefits of physical activity kindled by the COVID-19 crisis to implement new health-promoting policies. Policy design, development and implementation of HEPA promotion must be strengthened for post-COVID-19 social and economic recovery.