bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement-device-independent Quantum Key Agreement against Collective Noisy Channel
Authors: Zhou Yi-Hua , Xu Yang , Yang Yu-Guang , Shi Wei-Min , Chen Ze-Song 
Published: May 2022

Abstract
Quantum key agreement (QKA) permits participants to constitute a shared key on a quantum channel, while no participants can independently determine the shared key. However, existing Measurement-device-independent (MDI) protocols cannot resist channel noise, and noise-resistant QKA protocols cannot resist side-channel attacks caused by equipment defects. In this paper, we design a MDI-QKA protocol against collective-dephasing noise based on GHZ states. First, in our protocol, Alice and Bob prepare a certain number of GHZ states respectively, and then send two particles of each GHZ state to Charlie for bell measurement. Results are that Alice and Bob can obtain Bell states through entanglement exchange with the help of dishonest Charlie. Meanwhile ensures the transmission process noise-resisted. Then, Alice and Bob encode their key components to the particle in their hands and construct logical quantum states against collective noise through additional particles and CNOT operation to implement MDI-QKA. Compared with existing MDI-QKA protocols, our protocol uses logical quantum states during particle transfers, which makes the protocol immune to collective‑dephasing noise, and therefore improving the final key rate. Security analysis shows that our protocol can resist common insider and outsider attacks.
Preliminary structural proteome of the monkeypox virus causing a multi-country outbreak in May 2022
Authors: Parigger Lena , Krassnigg Andreas , Grabuschnig Stefan , Resch Verena , Gruber Karl , Steinkellner Georg , Gruber Christian C. 
Published: May 2022

Abstract
The monkeypox virus (MPX) belongs to the orthopoxvirus genus of the Poxviridae family, is endemic in parts of Africa, and causes a disease in humans similar to smallpox. The most recent outbreak of MPX in 2022 is already affecting 19 countries on different continents and has consequently become a focus of interest. In particular, a molecular understanding of the virus is essential to study infection processes and pathogen-host interactions, predict tropism changes, or guide drug development and discovery as well as vaccine development or adaptation at a very early stage. Herein we present a study of the structural genome of the currently emerging MPX virus: our analysis revealed 10,043 characteristic candidate open reading frames (ORFs), and a subsequent BLAST search of the non-redundant protein database and PDB reduced the number of suspected ORFs to 925 and 123 protein sequences, respectively. Finally, we provide the 3D structures of these 123 protein sequences, which were predicted by homology modeling and are available for download.
In-Vitro results of EG-Covimab-H (Lab cultivated Human polyclonal antibodies) for neutralizing SARS-CoV-2 Virus &amp; safety on tissues.
Authors: Mohammed Alaa Abdelkarim , C Prof. Datuk Sri Mike 
Published: May 2022

Abstract
AbstractThe debate between the active immunisation versus the passive immunisation has been the subject of discussion since the start of SARS-CoV-2 pandemic. the second debate was monoclonal antibodies versus the polyclonal antibodies in the passive vaccination, which one is more potent and more safe for the patients. Which one is valuable for the industry and the patient in the same time. While this is not the subject of this research, but this research adopted the polyclonal antibodies with new technique in production to cope with the industry needs and at the same time to achieve the best results for the patients. EG-Covimab-H, is a polyclonal antibodies derived from cultivating Switched memory B-Lymphocytes from convalescent patient (2-6 after testing negative and recovering from moderate to sever infection). The isolated B Lymphocytes are cultivated in special media and Antibodies were harvested and used in this research. The research focus in testing the tissue toxicity and ability of EG-Covimab-H in neutralizing the SARS-CoV-2 Virus that infected the tissue culture.Tissue culture was done on VERO-6 Cells. EG-Covimab-H was tested for 120 hours on different dilutions (1/2,1/4,1/8,1/16,1/32,1/64, up to 1/2056). The result of the toxicity test showed 90-100% safety in the dilution of 1/8 and 1/16 respectively. Therefore, the efficacy test was done with the safe dilution and in the same dilution algorithm. The result came as effectiveness is 95%-965 success in neutralizing the virus within 96 hours.The neutralization curve did not show any surge in the number of virus copies after applying the polyclonal antibodies and the decline in the number started to show within 48 hours.
The functions of safety in psychotherapy: A comparative analysis across therapeutic schools
Authors: Podolan Martin 
Published: May 2022

Abstract
There is a certain consensus in the psychotherapeutic literature that safety plays a central role in human development and psychotherapy and that lack of safety undermines mental health. Nevertheless, the role of safety in psychotherapy has not yet been systematically examined. Therefore, we analyzed and compared the concept of safety across some main psychotherapeutic schools (psychodynamic, cognitive-behavioral, humanistic). Our goal was to identify and integrate the different functions of safety in psychotherapy on a transtheoretical basis. Our analysis showed that safety is rightly prioritized across psychotherapy schools mainly because a lack of safety activates psychobiological defense systems. Our findings suggest that the main role of safety is to secure survival, facilitate restoration, promote exploration, sustain risk-taking, and enable integration, with these functions being complementary and dependent on the context. It appears that the effective functioning of human development and psychotherapy does not require the continuous maintenance of the maximum possible safety, but enough safety. Although safety provides the necessary basis for an adequate ontogenetic development as well as for treatment progress, safety’s misdosage (e.g., lack, excess), misconstruction (e.g., misattunement, misinterpretation), or misuse (exploitation, idealization) may hinder the healthy development of attachment, identity, autonomy, self/co-regulation as well as the ability to tolerate and cope with dangers, risks, insecurities, or frustrations, with negative consequences on the therapeutic process. Future research is suggested to further explore the role of safety in psychotherapy.
The Importance of Gravity Vector on Adult Mammalian Organisms: Effects of Hyper-Gravity on Mouse Testis
Authors: Bonetto Valentina , Magnelli Valeria , Sabbatini Maurizio , Caprì Flavia , Tavella Sara , Masini Maria Angela 
Published: May 2022

Abstract
In the time of space explorations, the effect of hyper-gravity on the human physiology is a topic relatively neglected. Nevertheless, astronauts have several experiences of hyper-gravity during their mission. The main disturbance of altered gravity can be imputed to cell cytoskeleton alteration and physiologic homeostasis of the body. Testis has been revealed to be an organ particularly sensible, to be affected by environmental alteration and physiological disturbance. This makes testis an organ eligible for investigating the alteration following exposure to altered gravity. In our study, mice were exposed to hypergravity (3g for 14 days) in Large Diameter Centrifuge. We have observed morphological alteration of the regular architecture of the seminiferous tubules of testis as well as an altered expression of factors involved in junctional complexes of Sertoli cells, responsible to assure the morpho-functional integrity of the organ. The expression of key receptors in the physiological performance, such as Androgen Receptors and Interstitial Cells Stimulating Hormone (ICSH) receptors have been found lower expressed. All these findings indicate the occurrence of altered physiological performance of the organ such as the reduction of the spermatozoa number and an altered relationships with the endocrine physiology following hypergravity exposure.
Exploring Pattern Recognition: What is the relationship between the recognition of words, faces and other objects?
Authors: Maratos Frances , Chu Kar-Man , Lipka Sigrid , Stupple Edward , Parente Fabio 
Published: May 2022

Abstract
Debate surrounds processes of visual recognition, with no consensus as to whether recognition of distinct object categories (faces, bodies, cars, and words) is domain specific or subserved by domain-general visual recognition mechanisms. Here, we investigated correlations between the performance of 74 participants on recognition tasks for words, faces and other object categories. Participants completed a counter-balanced test battery of the Cambridge Face, Car and Body Parts Memory tests, as well as a standard lexical decision task with response time (RT) and accuracy as dependent variables. We found that response times were consistently positively and significantly correlated between most object categories; for example, face recognition with body and car recognition, but also with word and non-word recognition. However, correlations between accuracy scores were more limited; for example, face recognition did not correlate with non-word recognition. Additionally, controlling for dyslexia resulted in some correlations becoming more robust (e.g., regular- and irregular-word recognition accuracy) or emerging (e.g., RT between body and real-word recognition), whilst others were partialled out (e.g., recognition accuracy between irregular words and confusable non-words). These results suggest some degree of functional overlap in the neural mechanisms subserving recognition of these different object categories, generally supporting a domain-general view of pattern recognition. This stated, observed relationships were complex. In order to further our understanding of pattern recognition, research investigating the recognition of words, faces and other objects in dyslexic individuals is recommended, as is research examining developmental trajectories of pattern recognition and research exploiting neuroimaging methodologies.
The Role of Sesamin in Targeting Neurodegenerative Disorders: A Systematic
Review
Authors: Ghaderi Mohammad Amin , Emami Seyed Ahmad , Beirak Olia Mahla Daliri , Javadi Behjat 
Published: May 2022

Background:
Neurodegenerative Diseases (NDs) are characterized by progressive neuronal
deterioration as a result of several pathogenesis mechanisms. Phytochemicals, including sesamin with
multitarget activities, have been studied widely.

Objective:
In this review, we aim to survey the neuroprotective effects of sesamin on NDs and its
mechanisms of action.

Methods:
Searching GoogleScholar, PubMed, and Science Direct databases, we reviewed original
English language articles on sesamin effects against NDs, specifically Alzheimer’s Disease (AD) and
Parkinson's Disease (PD), either in vivo or in vitro settings, with no time limitation.

Results:
Sesamin has been reported to interfere with NDs progression through its antioxidative, antiinflammatory,
and antiapoptotic actions in most of the retrieved studies. Sesamin also can prevent
amyloid-β aggregation in AD models and elevate dopamine levels in PD-induced models.

Conclusion:
The results of this study revealed the beneficial effects of sesamin in the prevention and
management of NDs, including AD and PD; however, no clinical data supporting these effects in humans
is available, which highlights the need for designing clinical trials to evaluate the efficacy, proper
dosage, pharmacokinetics aspects, and possible side effects of sesamin in humans.
The Reactions of p-Tosylmethyl Isocyanide with Aldehydes in the Synthesis
of Heterocyclic Compounds: A Review
Authors: Vchislo Nadezhda V. , Fedoseeva Victoria G. , Verochkina Ekaterina A. 
Published: May 2022

Abstract:
p-Tosylmethyl isocyanide (TosMIC) and its derivatives represent an important class of polyfunctional reagents, which makes them privileged “building blocks” in the targeted organic synthesis to design a plethora of heterocycles as well as natural products. This review summarizes and highlights the synthetic potential of p-tosylmethyl isocyanide and its derivatives in the reaction with various aldehydes to afford valuable heterocycles. The catalytic and technological innovations discussed in the review reveal the ease of reaction that is displayed in mechanistic schemes.
Engineered BMSCs-Derived Exosomal miR-542-3p Promotes Cutaneous
Wound Healing
Authors: Li Xiao-Lin , Xiong Qing-Hua , Zhao Lei , Wan Guan-Qun , Hu Yun-Gang 
Published: May 2022

Background:
The healing of cutaneous wounds requires better strategies, which remain
a challenge. Previous reports indicated that the therapeutic function of mesenchymal stem cells is
mediated by exosomes. This work demonstrated the regenerative effects of engineered BMSCsderived
Exosomal miR-542-3p in skin wound mouse models.

Methods:
Bone marrow mesenchymal stem cells (BMSCs) -derived exosomes (BMSCs-Exos) were
isolated by ultracentrifugation and identified by Transmission Electron Microscope (TEM) and
Nanoparticle Tracking Analysis (NTA). BMSCs-Exo was loaded with miRNA-542-3p by
electroporation. We explored the effects of miRNA-542-3p-Exo on the proliferation and migration
of Human Skin Fibroblasts (HSFs)/Human dermal microvascular endothelial cells (HMECs). In
addition, The angiogenesis of HMECs was detected by Tube formation assay in vitro. The effects
of miRNA-542-3p-Exo in the skin wound mouse model were detected by H&E staining, Masson
staining, and immunofluorescence analysis. We assessed the effect of miRNA-542-3p-Exo on
collagen deposition, new blood vessel formation, and wound remodeling in a skin wound mouse
model.

Results:
MiRNA-542-3p-Exos could be internalized by HSFs/HMECs and enhance the
proliferation, migration, and angiogenesis of HSFs/HMECs in vitro and in vivo. The protein
expression of collagen1/3 was significantly increased after miRNA-542-3p-Exo treatment in HSFs.
In addition, the local injection of miRNA-542-3p-Exo promoted cellular proliferation, collagen
deposition, neovascularization, and accelerated wound closure.

Conclusion:
This study suggested that miRNA-542-3p-Exo can stimulate HSFs/HMECs function.
The treatment of miRNA-542-3p-Exo in the skin wound mouse model significantly promotes
wound repair. The therapeutic potential of miRNA-542-3p-Exo may be a future therapeutic strategy
for cutaneous wound healing.
Computational Studies and Biological Evaluation on Synthesized Lead 1,3-
diphenyl-4,5-dihydro-1H-pyrazole Moiety as Anti-Infective Agents
Authors: Manickavalli Elangovan , Kiruthiga Natarajan , Vivekanandan Lalitha , Roy Anitha , Sivakumar Thangavel 
Published: May 2022

Background:
Chronic non communicable diseases were interlinked with inflammation and infections should response to starting core of major diseases in both acute and chronic conditions. In drug discovery, development of a drug which acts as anti-infective agents (anti-microbial and anti-inflammatory) must be ideal and challenging for management of many chronic diseases.

Objective:
In this study, six lead pyrazoline hybrids were synthesized by cyclization of chalcones and characterized by various spectroscopic and elemental analysis. All synthesized compounds were screened for anti-inflammatory and anti-microbial activity by computational tools and biological evaluation.

Methods:
Synthesized pyrazoline analogues were characterized by various spectroscopic techniques and evaluated for prediction of pharmacokinetics, physicochemical properties and Molecular docking studies of various targeted enzymes on microbial and inflammatory mediators. Those compounds were screened by anti-microbial and anti-inflammatory activities by several in-vitro and in-vivo methods.

Results:
The synthesized compounds (A1-A6) were screened for anti-inflammatory activity in which compound A2 produced effective percentage inhibition (45.8 %) potent activity compared with that of standard indomethacin (49.7 %) in carrageenan paw edema method were observed. The anti-microbial activity was screened on synthesized compounds, among which A3 [2-(1,3-diphenyl-4,5-dihydro-1H-pyrazol-5-yl) phenol, A2 [5-(4-chlorophenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole] produced potential percentage zone of inhibition between 80 - 70 % for bacterial strains and 94 - 89 % for fungal strains were observed. The minimum inhibitory concentration values of those compounds were 1.56 to 6.25 µg/ml for bacterial strains and 1.56 to 12.5 µg/ml for fungal strains were noted compared with the standard gatifloxacin and clotrimazole, respectively. The molecular docking, pharmacokinetics and toxicity predictions on those compounds were supported further for the development of potent anti-infective agents.

Conclusion:
The hypothesis of this research was correlated with the results of anti-inflammatory and anti-microbial activity. The binding interactions of respective enzymes were coincided with reduction of paw edema in anti-inflammatory model and zone of inhibition in anti-microbial activity were observed.
WITHDRAWN: In silico and Experimental Analysis of miR-125b-5 and
miR-485-5p Expression in Serum of Patients with Breast Cancer
Authors: Derakhshan Sima Mansoori , Bahmanpour Zahra , Sheervalilou Roghayeh , Khaniani Mahmoud Shekari , Poursheikhani Arash , Montazeri Vahid , Tahmasebivand Mahsa 
Published: May 2022

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has
been withdrawn.

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Nephroprotective Effect of Methanolic Extract of Solanum nigrum (Mako) and its Fractions on Cisplatin-induced Nephrotoxicity in Albino Rats
Authors: Aslam Mohammad , Shiffa Mohamed , Javed Kalim , Rahman Shabana , Fahamiya Nazeem 
Published: May 2022

Background:
Renal failure is an emerging problem worldwide and it is defined as the presence of renal parenchymal damage. Its manifestations are abnormal albumin excretion or decreased kidney function. Solanum nigrum L. (Mako), ‘Black Nightshade’, belongs to the family Solanaceae known in Unani medicine for its nephroprotective activity, especially in renal disease, as the berries are used to treat many renal ailments including renal failure.

Aim:
The aim of this study was to evaluate the nephroprotective activity of the berries of Mako on cisplatin-induced nephrotoxicity in rats.

Methods:
Wistar rats were divided into 7 groups of six animals in each. Group I served as the control, group II the toxicant group (cisplatin only), group III included the methanolic extract of Mako, group IV petrol soluble fraction of ME, group V chloroform soluble fraction of ME, group VI water soluble fraction of ME, and group VII the water soluble fraction of ME. All groups except for control group received a single dose of cisplatin 7 mg/kg injection on the 4th day, and test drugs were co-administered from day 1 to day 7. On the 8th day, samples were collected for the analysis of blood urea nitrogen (BUN), serum creatinine and for histopathological examination of renal tissues.

Results:
Results were analyzed using the one-way analysis of variance followed by Dunnett’s post hoc test. It was revealed that the ME of Mako and its fractions significantly reduced the rise in BUN and serum creatinine levels caused by cisplatin. The histopathological analysis also showed the protective nature of Mako in the nephrotoxic modules.

Conclusion:
Hence, the biochemical parameters and histopathological results affirmed the nephroprotective effect of the berries of the Mako against cisplatin-induced renal damage.
The Impact of Telemedicine on Physicians’ After-hours Electronic Health Record “Work Outside Work” During the COVID-19 Pandemic: Retrospective Cohort Study
Authors: Lawrence Katharine , Nov Oded , Mann Devin , Mandal Soumik , Iturrate Eduardo , Wiesenfeld Batia 
Published: May 2022

Background
Telemedicine as a mode of health care work has grown dramatically during the COVID-19 pandemic; the impact of this transition on clinicians’ after-hours electronic health record (EHR)–based clinical and administrative work is unclear.

Objective
This study assesses the impact of the transition to telemedicine during the COVID-19 pandemic on physicians’ EHR-based after-hours workload (ie, “work outside work”) at a large academic medical center in New York City.

Methods
We conducted an EHR-based retrospective cohort study of ambulatory care physicians providing telemedicine services before the pandemic, during the acute pandemic, and after the acute pandemic, relating EHR-based after-hours work to telemedicine intensity (ie, percentage of care provided via telemedicine) and clinical load (ie, patient load per provider).

Results
A total of 2129 physicians were included in this study. During the acute pandemic, the volume of care provided via telemedicine significantly increased for all physicians, whereas patient volume decreased. When normalized by clinical load (ie, average appointments per day by average clinical days per week), telemedicine intensity was positively associated with work outside work across time periods. This association was strongest after the acute pandemic.

Conclusions
Taking physicians’ clinical load into account, physicians who devoted a higher proportion of their clinical time to telemedicine throughout various stages of the pandemic engaged in higher levels of EHR-based after-hours work compared to those who used telemedicine less intensively. This suggests that telemedicine, as currently delivered, may be less efficient than in-person–based care and may increase the after-hours work burden of physicians.