bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of metformin on the metabolism of human vascular smooth muscle cells in high glucose conditions
Authors: Soleimani Ali Akbar , Abkenar Borhan Rahimi , Shokri Nafiseh , Ghasempour Ghasem , Najafi Mohammad 
Published: April 2022

Abstract

Objectives
Metformin is widely used in type 2 diabetic patients as an antihyperglycemic drug. The aim of this study was to investigate the effect of metformin on the metabolism of vascular smooth muscle cells in high glucose conditions.

Materials and methods
The vascular smooth muscle cells were cultured in DMEM F12 containing glucose as high as 25 mM. The preconditioned cells were then treated with metformin in doses of 1, 5, and 7 mM for 24 h. MTT method was used to determine cell viability. Biochemical parameters including lactate, glucose, total protein, creatinine, and triglyceride were measured in the cell culture after the treatment with metformin. Oil Red O staining method was used to stain the lipids in the cells.

Results
Metformin reduced significantly (p<0.001) VSMC proliferation in a concentration-dependent manner. With the increase of glucose uptake by VSMCs, the cell lipid deposition was not changed. Other biochemical parameters such as lactate, triglyceride, total protein, and creatinine were significantly changed in the cell culture (p<0.05).

Conclusions
Metformin increased the glucose uptake impacting metabolic pathways in VSMCs. It also increased the lactate efflux and protein metabolism without the change in cellular lipid deposition in high glucose conditions.
Die Forderung nach Kulteinheit. Beobachtungen zu Struktur und Genese von Dtn 12
Authors: Lee Sang-Won 
Published: April 2022

Zusammenfassung
Die gegenwärtige Forschung sieht den ältesten Baustein des Kulteinheitsgesetzes zumeist in Dtn 12,13–19. Der Beitrag zeigt, dass dies (wie auch ein Textanfang mit 12,8–12) aus sprachlichen und sachlichen Gründen nicht plausibel ist. Analytisch erweisen sich zudem die vermeintlichen Dubletten in 12,1–19 als pragmatisch erforderliche Entfaltungen des Gesetzes auf der Ebene des DtrG. Darüber hinaus erschließt sich der großflächige Numeruswechsel in Dtn 12 als strukturell stimmig. Demgegenüber hat der Abschnitt 12,20–28 (neben diversen punktuellen Interpolationen) als jüngere Ergänzung zu gelten. Das DtrG als primärer Kontext des Grundtextes schließt eine ältere deuteronomische Vorlage nicht per se aus, da der literargeschichtliche Befund für einen solchen Rückschluss nachweislich nicht hinreicht.
Sapientialised Priest?: Reconsidering the Priestly Torah in Sirach
Authors: Kwon JiSeong James 
Published: April 2022

Abstract
Scholars have maintained that Ben Sira belongs to a priestly group, or a circle of scribe-sages subjugated to priests, and that the book of Sirach hints at a merger of the created and priestly orders. The book’s harmonization of sapiential and Zadokite strands of Judaism might justify its identification with Jerusalemite priestly groups, but it is misleading to conclude that Sirach merges these two separate traditions. Its wisdom discourses are an adaptation of Proverbs in which Ben Sira, as a Jewish scribe, grants authority and power to the Zadokites on the model of Proverbs’ divine wisdom.
Partial substitution of the Mn atoms in CaMnO3by first row transition metal atoms: effect on oxygen vacancy formation
Authors: Grimm Benjamin , Bredow Thomas 
Published: April 2022

AbstractSustainable hydrogen production is one of the most challenging topics in modern energy economics. Electrochemical and thermal splitting of water are promising techniques, but are highly energy demanding. Efficient hydrogen evolution reaction catalysts can play a key role to lower the electrolysis potential and to make water splitting more feasible. Among other perovskites, CaMnO3has been identified as efficient electrode material due to its relatively high oxygen vacancy concentrations at elevated temperatures. But this compound needs to be further improved for technical use. In this study, the effect of Mn substitution in CaMnO3by 3d metals M = Sc, Ti, V, Cr, Fe, Co, Ni, Cu and Zn on the oxygen vacancy formation energy is investigated theoretically at DFT level. Vacancy formation energies, enthalpies and free enthalpies are calculated with a combination of hybrid and GGA density functionals. Configuration entropy is taken into account by calculating all possible configurations of M and oxygen vacancy site in supercell models. The calculated oxygen vacancy formation energies are strongly affected by Mn/M substitution, the most promising heteroelement being Cu. CaMn0.875Cu0.125O2.875and CaMn0.875Cu0.125O2.75are in equilibrium at 537 K, compared to 1231 K for CaMnO2.875/CaMnO2.75and 1350 K for CaMnO3/CaMnO2.875.
Synthesis, antimicrobial activity and modeling studies of thiazoles bearing pyridyl and triazolyl scaffolds
Authors: Funda Tay Naime , Berk Barkın , Duran Murat , Kayagil İsmail , Yurttaş Leyla , Biltekin Kaleli Sevde Nur , Yamaç Mustafa , Karaduman Ayşe Betül , Demirayak Şeref 
Published: April 2022

Abstract
In this study, novel 4-(5-((2/3/4-substituted benzyl)thio)-4-(4-substituted phenyl)-4H-1,2,4-triazol-3-yl)-2-(pyridin-3/4-yl)thiazoles were synthesized following a multi-step synthetic procedure. All the compounds were screened with a panel of gram positive/negative bacteria, yeasts, and molds for antimicrobial activity using the disc diffusion method. Then, the minimum inhibitor concentration (MIC) and the minimum bactericidal concentration (MBC) values of active compounds were determined against Micrococcus luteus, Bacillus cereus, Listeria monocytogenes, and Staphylococcus aureus using the broth microdilution technique. These compounds were also screened for their inhibitory activities against S. aureus DNA gyrase by supercoiling assay. Furthermore, the crystal structure of S. aureus DNA gyrase B ATPase was subjected to a docking experiment to identify the possible interactions between the most active ligand and the active site. Lastly, the in silico technique was performed to analyze and predict the drug-likeness, molecular and ADME properties of the synthesized molecules.
Clinical and Renal Cortical Blood Perfusion Characteristics in Patients with Severe Atherosclerotic Renal Artery Stenosis Who Underwent Stent Implantation: A Single-center Retrospective Cohort Study
Authors: Li Yan , Sun Youjing , Wang Siyu , Ma Na , Li Mengpu , Ren Junhong , Li Yongjun , Ai Hu , Zhu Hui , Wang Yang , Guo Fajin 
Published: April 2022

Abstract

Objective This study aimed to observe the clinical imaging features of patients with severe atherosclerotic renal artery stenosis (ARAS) receiving stent implantation, and to evaluate the associations between baseline clinical and imaging factors and renal-function deterioration at a 1-year follow-up.

Methods This study was a single-center retrospective cohort study. A total of 159 patients with unilateral severe ARAS who underwent stent implantation at Beijing Hospital between July 2017 and December 2020 were consecutively enrolled. According to the renal glomerular filtration rate (GFR), detected by radionuclide renal imaging at 1-year follow-up, all patients were divided into a poor-prognosis group (with a ≥30% decrease in renal GFR; n=32 cases) and a control group (127 cases). Clinical imaging data, including the renal cortical blood perfusion pre- and post-sent implantation, were analyzed. Univariate and multivariate logistic regression analysis was used to evaluate the associations between clinical and imaging factors and renal-function deterioration.

Results Of the 159 patients enrolled, 83 (52.2%) were men, with an average age of (57.2±14.7) years. The patient age, rate of diabetes, and systolic blood and diastolic blood pressure in the poor-prognosis group were significantly higher than those in the control group (all P<0.05). Before stent treatment, patients in the poor-prognosis group, compared with the control group, had a significantly smaller area under the ascending curve (AUC1), area under the descending curve (AUC2), and peak intensity (PI), and a longer time to peak intensity (TTP) and mean transit time (MTT) (all P<0.05). After stent treatment, patients in the poor-prognosis group, compared with the control group, showed significantly smaller AUC1, AUC2, and PI, and longer MTT (all P<0.05). Multivariate logistic regression analysis indicated that age (OR=1.251, 95%CI: 1.113–1.406, P=0.0002), diabetes (OR=1.472, 95%CI: 1.110–1.952, P=0.007), systolic blood pressure (OR=1.339, 95%CI: 1.082–1.657, P=0.007), renal GFR (OR=2.025, 95%CI: 1.217–3.369, P=0.006), and AUC1 post-stent (OR=2.173, 95%CI: 1.148–4.113, P=0.017) were the factors associated with renal deterioration at the 1-year follow-up.

Conclusions Patients with severe RAS with renal-function deterioration after stent implantation were older, and often had diabetes, hypertension, and impaired renal cortical perfusion. Age, diabetes, systolic blood pressure, renal GFR, and AUC1 after stent implantation were independent factors associated with short-term renal deterioration.
Erratum - Journal Scientia Medica v.31 n.1 (2021) - ID 40589
Authors: Periódicos EDIPUCRS 
Published: April 2022

The Editorial Team of Journal SCIENTIA MEDICA publishes the following changes and replacements, in the edition 31, n. 1 (2021), DOI: https://doi.org/10.15448/1980-6108.2021.1.40589, ID 40589, article, The 12 women who won the Nobel Prize in Medicine or Physiology
A new species and a new record of Malaxis (Malaxidinae) from Costa Rica
Authors: Chinchilla Isler F. , Karremans Adam P. , Blanco Mario A. 
Published: April 2022

We describe and illustrate a new species and a new record of Malaxis from the lower montane and montane forests of Costa Rica. Taxonomic descriptions, illustrations, distribution maps, and conservation assessments are provided for each species. Malaxis excentrica sp. nov. is morphologically similar to Malaxis simillima, from which it can be distinguished by having a single leaf per sympodial unit, shorter, obovate, erect petals parallel to the column, the lip with triquetrous, acute, convex apical margin and the disc cavity divided by a costa. Malaxis pittieri is formally recorded for the flora of Costa Rica; Costa Rican specimens of this species were previously confused with Malaxis majanthemifolia. A lectotype for Microstylis pittieri is formally designated.
High performance thin layer chromatography (HPTLC) method development and validation for the simultaneous determination of paracetamol, caffeine, chlorpheniramine and phenylepherine in tablet formulation
Authors: Arage Almaz , Layloff Thomas , Hymete Ariaya , Ashenef Ayenew 
Published: April 2022

AbstractA rapid, selective, and precise high performance thin layer chromatographic method was developed and validated for the simultaneous analysis of paracetamol, caffeine, phenylephrine and chlorpheniramine in tablets. The chromatographic analysis was carried out on glass plates pre-coated with silica gel 60 F254 as a stationary phase. The optimized mobile phase was methanol : n-butanol : toluene : acetic acid (8:6:4:0.2 v/v). TLC chamber of 10 × 20 cm was used with saturation time of 15 min. The retardation factor (RF) for chlorpheniramine, phenylephrine, caffeine and paracetamol was found to be 0.15 ± 0.02, 0.29 ± 0.02, 0.50 ± 0.02, 0.68 ± 0.02 respectively. Detection was carried out at 212 nm. Validation study was done following ICH Q2 (R1) guideline. The regression data for the calibration plots showed good linear relationship with R2 = 0.997 over the concentration range of 300–1,500 ng band−1 for caffeine, R2 = 0.996 over the concentration range of 100–500 ng band−1 for phenylephrine, R2 = 0.996 over the concentration range of 200–600 ng band−1 for chlorpheniramine, R2 = 0.998 over the concentration range of 400–2,400 ng band−1 for paracetamol. The method was validated for precision, accuracy and recovery. Minimum detectable amounts were found to be 304.9 ng band−1, 87.88 ng band−1, 117.18 ng band−1 and 143.06 ng band−1 for caffeine, phenylephrine, chlorpheniramine, and paracetamol respectively while the limit of quantification was found to be 923.95 ng band−1, 266.32 ng band−1, 355.11 ng band−1, and 433.53 ng band−1 in the same order. The method was successfully applied to analyze two marketed tablets in a selective and reproducible manner.
Absinthe against multi-drug resistant bacterial pathogens? A recent update on the antibacterial effects of Artemisia compounds
Authors: Janz Josephine , Shayya Nizar W. , Bereswill Stefan , Heimesaat Markus M. 
Published: April 2022

Abstract
The widespread misuse of antibiotics leads to a rapid development of multi-drug resistant (MDR) bacterial pathogens all over the globe, resulting in serious difficulties when treating infectious diseases. Possible solutions are not limited to the development of novel synthetic antibiotics but extend to application of plant-derived products either alone or in combination with common antibiotics. The aim of this actual review was to survey the literature from the past 10 years regarding the antibacterial effects of distinct Artemisia species including Artemisia absinthiae constituting an integral component of the Absinthe drink. We further explored the synergistic antibacterial effects of the Artemisia plant products with established antibiotics. The survey portrays the Artemisia derived compounds as potent antibacterial agents that can even restore the efficacy of antibiotics against MDR bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) and MDR Escherichia coli. This, in turn, is presumably triggered in part by the interaction of the Artemisia ingredients with the efflux pumps of MDR bacteria. In conclusion, biologically active molecules in Artemisia plants enhance the antibiotic susceptibility of resistant bacteria, which provide promising future therapeutic strategies to combat MDR bacterial pathogens.
ANALISIS DAYA DUKUNG KAWASAN DAN POTENSI EKOWISATA BAHARI DI PROVINSI BANTEN
Authors: Rahman Abdul 
Published: April 2022

Potensi wisata di Provinsi Banten yang menarik minat wisatawan diantaranya adalah pada wisata bahari (Pantai Anyer, Tanjung Lesung, Pantai Sawarna, Pulau Peucang, dan Pulau Burung). Penelitian ini bertujuan untuk mengetahui Daya Dukung Kawasan (DDK), Indeks Kesesuaian Wisata (IKW) ekowisata bahari dan untuk menganalisis potensi nya di Provinsi Banten. Penelitian ini dilakukan di 4 Kabupaten dan 1 kota, dengan 11 lokasi objek wisata yang dijadikan sampel. DDK di 11 lokasi pantai tertinggi yaitu 180 orang/50 mpanjang pantai yaitu di Pantai Sawarna (Lebak), di Pantai Pulau dua (Serang) dengan DDK 20 orang/50 mper hari. DDK wisata mangrove didapat dari dua lokasi yaitu PRPM Kronjo (Tangerang) dengan 72 orang/50 m2 dan Cagar Alam Pulau Dua (Serang) dengan 32 orang/50 m2 per hari. Sedangkan untuk DDK wisata snorkeling yang tertinggi yaitu; Spot Ciapus 8 orang/50 m2, dan terendah di Pulau Badul 3 orang/50 m2 per hari. Pantai Pulau Peucang (Uj. Kulon) memiliki nilai IKW tertinggi yaitu 96.67% dan yang terendah di Pantai Pulau Cangkir (Tangerang) yaitu 55.6%, Kategori rekreasi mangrove terdapat di dua lokasi yaitu; ekowisata mangrove PRPM Kronjo dengan nilai IKW 55.55% dan ekowisata mangrove Cagar Alam Pulau Dua dengan nilai IKW tertinggi 81.25%. Kategori rekreasi snorkelling tertinggi yaitu; Spot Legon Sumino dengan Nilai IKW 91.23% dan terendah di Pulau Badul dengan Nilai IKW 80.7%.
Study on the role of nutrients in food to improve the motion state of athletes
Authors: Zhou Hongkai 
Published: April 2022

This study aims to analyze the role of nutrients in food in improving athletic performance and to understand the feasibility of food supplementation in sports training. Twenty athletes were randomly divided into two groups, A and B. The athletes in the two groups had the same diet and the same training content and differed only in the supplemented food. Group A was supplemented with Siraitia grosvenorii water, and Group B was supplemented with pure water. After 3 months of training, the body composition, exercise status, and blood indexes of the athletes in the two groups were compared. Compared with the athletes in group A before the experiment as well as in group B after the experiment, the athletes in group A showed a significant increase in fat-free weight, improved athletic performance, increased levels of hemoglobin (Hb) and red blood cell (RBC), and decreased levels of blood lactic acid (BLA) and blood urea nitrogen (BUN) (P < 0.05). Nutrients in food can effectively improve the body composition and exercise status of athletes and inhibit the decrease of Hb and RBC as well as the increase of BLA and BUN, which have good usability in sports training.
Treatise <i>De adventu Medici ad aegrotum</i> — the attitude of doctors to the disease and its treatment, an example of the Salerno Medical School
Authors: Rodionova Yu. V. 
Published: April 2022

The article presents a translation of an anonymous treatise De adventu Medici ad aegrotum in Russian, the origin of which is attributed to the Salerno School of Medicine. Using the example of the treatise, it is possible to determine what characteristic the doctors of the XIII century attached to the disease, and the tasks of the doctor’s craft.The philosophy of healing the body is based on an understanding of nature as an instrument created by God, and not on the influence of divine power (will), which makes a decision about healing in each individual case (individually for each patient). The origin of the disease of the body is considered a consequence of some kind of influence on substance, an overabundance of substance affects nature, which resists and strives for the return of balance and its integrity.
La legitimidad de los actos administrativos electrónicos en el marco de las actuaciones administrativas
Authors: Mondragón Duarte Sergio Luis 
Published: April 2022

La presente investigación tiene como objetivo dar a conocer la legitimidad de los actos administrativos electrónicos en el marco de las actuaciones administrativas, para lo cual se aborda el tema por medio de un enfoque cualitativo, basado en el método hermenéutico, que permite dilucidar el alcance de los resultados de la investigación por medio de la interpretación de textos normativos, jurisprudenciales y doctrinales.
En ese sentido, partiendo de una revisión documental exhaustiva de fuentes bibliográficas confiables, se obtiene como resultado principal de esta pesquisa, que los actos administrativos electrónicos tienen la misma validez que los actos administrativos físicos, siempre que satisfagan los requisitos de autenticidad, integridad y disponibilidad, para efectos probatorios, tanto ante la misma administración como ante la administración de justicia, en el marco del principio de equivalencia funcional.
PENGGUNAAN MEDIA GAMBAR MOTIF BATIK UNTUK MENINGKATKAN KETERAMPILAN MENDESAIN BATIK TULIS PADA MATA PELAJARAN BATIK KELAS XI TEKSTIL SMKN 5 MALANG
Authors: Widjiastuti Risdwi Soenoe 
Published: April 2022

ABSTRACTThis study aims to determine the most effective teaching methods to improve students' understanding and skills of the batik design. The best method is expected to be implemented so that students will be able to make batik with attractive designs. The study was conducted to 10 students from class XI in SMKN 5 Malang with the methods applied gradually until three times of the learning process. Thus, the learning method that was applied up to three times showed the best results, as more and more students were able to design creative batik theme.Keyword : Picture,motif,design,written batik
PERANCANGAN KAMPANYE RUMAH DARING “RADAR” SEBAGAI FASILITAS PEMBELAJARAN DARING DI DRIYOREJO GRESIK PADA ERA PANDEMI COVID-19
Authors: Ramadhani Fitria , Sutopo Rich Al-Bahy 
Published: April 2022

Abstrak. Sejak terjadinya pandemi Covid-19 di Indonesia pada awal bulan Maret tahun 2020 kegiatan pembelajaran dilakukan secara daring. Langkah ini dilakukan oleh pemerintah demi mencegah penularan virus corona pada pelaksanaan kegiatan belajar mengajar. Pembelajaran daring dilaksanakan melalui platform pembelajaran yang serba online sehingga membutuhkan perangkat dan jaringan yang memadai. Sayangnya tidak semua pelajar di Indonesia memiliki akses jaringan yang memadai untuk melakukan pembelajaran daring salah satunya pada kecamatan Driyorejo, Kabupaten Gresik. Kampanye sosial “RADAR” hadir sebagai solusi dalam pengadaan jaringan di daerah yang terkendala jaringan. Kampanye sosial ini mengajak masyarakat Kecamatan Driyorejo Kabupaten Gresik tepatnya di RT 46 Perumahan Sumput Asri untuk mengadakan rumah daring sebagai tempat belajar dan media pendukung bagi anak-anak yang memiliki kendala jaringan saat pembelajaran daring.Kata Kunci: daring, pendidikan, Covid-19, kampanye sosial
Pengaruh Pembiayaan Murabahah, Musyarakah, dan Biaya Transaksi Terhadap Profitabilitas Bank Pembiayaan Rakyat Syariah 2018-2021
Authors: Maulana Fauzan Ibnu 
Published: April 2022

Abstrak:
Penelitian ini adalah bertujuan untuk menganalisis pengaruh Pembiayaan yang mendominasi pada BPRS yaitu Murabahah, Musyarakah, dan Biaya Transaksi yang dikeluarkan terhadap Profitabilitas BPRS. Bank Pembiayaan Rakyat Syariah adalah bank syariah yang dalam kegiatannya tidak memberikan jasa dalam lalu lintas pembayaran. BPRS lebih mengutamakan untuk memberikan pembiayaan kepada usaha mikro, kecil, dan menengah. Secara garis besar BPRS merupakan suatu bank yang memiliki prinsip syariah tidak menyediakan jasa dalam lalu lintas kegiatan pembayaran. Jenis bank seperti BPRS ini berbeda dengan Bank Perkreditan Rakyat (BPR) yang lebih dulu dikenal nasabah di Indonesia. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan data sekunder. Metode pengumpulan data yang digunakan adalah studi kepustakaan dan dokumentasi. Data penelitian diambil dari laporan statistik perbankan syariah perbulan pada 2018 - 2021 yang dapat diakses melalui situs resmi Otoritas Jasa Keuangan dan Bank Indonesia. Metode peneltian ini adalah menggunakan Statistik Deskriptif, Uji Asumsi Klasik (multikolonieritas, heteroskedastisitas, normalitas, dan autokorelasi), Analisis Regresi Linier Berganda, dan Uji Hipotesis. Dengan bantuan software IBM SPSS Statistics Versi 22. Hasil estimasi menunjukkan bahwa pembiayaan Murabahah, Musyarakah, dan Biaya Transaksi berpengaruh secara signifikan terhadap profitabiltas (ROA), namun NPF tidak berpengaruh secara signifikan terhadap profitabiltas (ROA) Bank Pembiayaan Bank Rakyat Syariah.
Kata Kunci: Murabahah, Musyarakah, Biaya Transaksi, Profitabilitas, dan Normalitas
ANALISIS KINERJA AC MOBIL DENGAN VARIASI FREON R-134A, HFC-134 DAN MC-134
Authors: Subagyo Rachmat Subagyo , Oktapiyanor Feri , Fadliyanur  , Muchsin  , Nanlohy Hendry Y. 
Published: April 2022

Upaya manusia untuk menciptakan kondisi yang lebih sejuk dilakukan dengan sistem Air Conditioning (AC), salah satu AC yang digunakan pada sistem transportasi yaitu AC mobil. Coefficient of Performance (COP) merupakan perbandingan efek refrigerasi dengan kerja kompresor. Efek refrigerasi dikalkulasikan dari besarnya enthalpy refrigerant yang masuk kompresor atau enthalpy yang keluar dari evaporator dibagi dengan enthalpy refrigerant yang masuk evaporator atau enthalpy sesudah katup ekspansi. Secara lebih jelas bahwa Coefficient of Performance (COP) adalah perbandingan efektifitas pendinginan evaporator dengan kerja yang diberikan kompresor. Penelitian ini bertujuan untuk menghitung dan membandingkan Coefficient of Performance Refrigerant jenis R-134A, HFC-134 dan MC-134. Metode yang digunakan adalah secara eksperimental dengan mengkaji nilai efisiensi dari AC mobil toyota avanza 1.3cc dengan variasi Freon R 134A, HFC 134A dan MC 134. Hasil penelitian menunjukkan nilai COP aktual dan COPideal yang terbaik menggunakan MC-134 karena nilai konduktivitas termal MC-134 paling tinggi sehingga kalor yang diserap evaporator lebih tinggi yang membuat nilai dari COP yang didapat lebih tinggi. Untuk efisiensi kompresor yang terbaik menggunakan HFC-134 karena nilai viskositas dan densitas dari HFC-134 lebih tinggi yang membuat kerja kompresor lebih ringan sehingga membuat efisiensi kompresor lebih tinggi