bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turnover intentions and safety compliance in the military: A psychological contract perspective
Authors: Kraak Johannes M , Griep Yannick , Barbaroux Pierre , Lakshman C 
Published: November 2022

NATO members have been coping with low motivation and morale. Such environments typically have high turnover intentions and neglect behavior. However, safety behavior is paramount for military organizations and neglect behavior can have serious consequences. Social exchanges are often cited as the main reason for these phenomena. We therefore examine turnover intentions and safety compliance behavior of 1,593 airmen from a European NATO Air Force by focusing on different psychological contract (PC) dimensions. We use polynomial regression and response surface analysis. Results show that higher levels of PC fulfillment are related to lower levels of turnover intentions and higher levels of safety compliance behavior. Furthermore, perceptions of PC overfulfillment are negatively associated with turnover intentions, whereas safety compliance is unaffected by positive (overfulfillment) and negative (underfulfillment) PC discrepancies along all PC dimensions. We discuss implications for the PC literature, make suggestions for future research, and provide practical implications. JEL CLASSIFICATIONS: M0 - general; M1 - business administration; C3 - Multiple or Simultaneous Equation Models; Multiple VariablesKeyword
Bone Marrow Stimulation and Biologics for Osteochondral Lesion of the Talus: A Systematic Review and Meta-Analysis of Clinical Comparative Studies
Authors: Ubillus Hugo A. , Seow Dexter , Azam Mohammad T. , Yasui Youichi , Mercer Nathaniel P. , Weiss Matthew B. , Pearce Christopher J. , Kennedy John G. 
Published: November 2022

Category: Ankle; Ankle Arthritis; Basic Sciences/Biologics; Sports; Trauma Introduction/Purpose: Osteochondral lesion of the talus (OLT) is a commonly occurring injury, typically treated with bone marrow stimulation (BMS) in the small to medium-sized lesions after a failed course of conservative treatment. The current evidence suggests that biologics can improve chondrocyte growth and differentiation. However, the lack of consensus to date on the efficacy of biologics + BMS for OLT has warranted further investigation. The purpose of this study is to clarify the effectiveness and safety of biologics as an augmentation in BMS by assessing complication rates, continuous functional outcome scores and return to play data compared to BMS alone for OLT. Methods: A systematic review and meta-analysis were performed. The PubMed and Embase databases were searched using specific search terms and eligibility criteria according to the PRISMA guidelines. The level of evidence was assessed using published criteria by The Journal of Bone & Joint Surgery and the quality of evidence using the Modified Coleman Methodology Score. Fixed- effects models were employed if heterogeneity was graded low (I2 <25%), and random-effects models if heterogeneity was graded moderate to high (I2>=25%). Results: For BMS versus BMS + hyaluronic acid (HA), the fixed-effects model for American Orthopaedic Foot and Ankle Society score revealed a mean difference increase that is an improvement of 4.88 (95% CI, 2.33 to 7.44; I2 = 0%; p = 0.0002) points, in favor of BMS + HA. The fixed-effects model for 10mm Visual Analog Scale pain revealed a mean difference decrease that is an improvement of 1.21 (95% CI, 0.70 to 1.73; I2 = 0%; p < 0.00001) points, also in favor of BMS + HA. For BMS versus BMS + concentrated bone marrow aspirate (CBMA), the pooled complication rate was 17/64 (26.6%) versus 11/71 (15.5%), respectively, with a chi-squared test of p = 0.11. The pool revision rate was 15/64 (23.4%) versus 6/71 (8.5%), respectively, with a chi-squared test of p = 0.016. Conclusion: Adjuvant biologic use with BMS may provide superior outcomes, notably that of HA and CBMA, based on the current evidence. Future studies must aim to establish the clinical superiority of the various other biologics + BMS versus BMS alone. These studies must compare the various biologics against one another to determine, if any, the optimal biologic for OLT.
What are the Major Risk Factors for Nonunion in Pilon Fractures?
Authors: Wilson Anthony L. , Boyd Brandon , Cichos Kyle , Murali Sudarsan , Mihas Alexander K. , Patch David A. , McGwin Gerald , Johnson Michael D. , Spitler Clay A. 
Published: November 2022

Category: Trauma; Ankle Introduction/Purpose: Pilon fractures are difficult injuries to manage as they are typically associated with extensive soft tissue damage. Although staged management of external fixation followed by open reduction and internal fixation is often used to prevent additional soft tissue damage and its associated complications, rates of nonunion remain high in this patient population. The purpose of this study is to evaluate and identify factors associated with increased rates of nonunion following operative fixation of pilon fractures. Methods: A retrospective review of all operatively managed pilon fractures at a single level 1 trauma center from 2014 to 2019 was performed. Minimum six-month follow-up was required for inclusion. Patients with skeletal immaturity or amputation prior to definitive fixation were excluded. Patients were grouped based on presence or absence of nonunion, which was defined as lack of bridging bone in at least 3 of 4 cortices and the presence of pain with ambulation at six-month follow-up. Demographics, injury and operative characteristics, and surgical outcomes were compared between the two groups. Results: Among the 279 patients meeting inclusion criteria, 48 developed nonunion at 6-month follow-up (17.2%). Average follow-up was 3.2 years. Patients with nonunion had significantly higher rates of open fractures (50.0% vs. 22.1%, p<0.001) and more required skin grafts (14.6% vs. 5.6%, p=0.029), muscle flap coverage (12.5% vs. 2.6%, p=0.002), and bone grafting (25.0% vs. 3.9%, p<0.001) compared to controls. Those who developed nonunion had significantly lower rates of medial column fixation (43.8% vs. 67.5%, p=0.002) and higher rates of surgical site infection (45.8% vs. 7.8%, p<0.001). Rates of AO/OTA 43C fractures (70.8% vs. 52.4%) and fractures treated with plates overlapping the site of external fixation (39.5% vs. 26.6%) were higher in the nonunion group, but did not reach statistical significance (p=0.064 and p=0.098). There were no significant differences in demographics, mechanism of injury, Gustilo-Anderson classification, associated ipsilateral lower extremity injuries, surgical approach, or type of fixation between the two groups. Conclusion: In the present study, pilon fractures were found to have a nonunion rate of 17.2% at six-month follow-up. Nonunion was associated with the presence of open fracture, need for soft tissue coverage or bone grafting, and surgical site infection. Medial column fixation was associated with a lower rate of nonunion in these fractures.
Is It Safe to Prep the External Fixator in Situ During Staged ORIF of Pilon Fractures? A Retrospective Comparative Cohort Study
Authors: Yeramosu Teja , Hayes Amanda , Young Porter , Cinats David , Kates Stephen , Patel Tejas J. , Perdue Paul W. 
Published: November 2022

Category: Trauma; Ankle Introduction/Purpose: Pilon fractures usually result from high energy mechanisms and are associated with signifcant soft tissue injuries in addition to complex fracture patterns. Treatment typically involves staged management with initial placement of an external fixator and subsequent definitive internal fixation once soft tissues are amenable. The purpose of this study was to compare the risk of fracture-related infection (FRI) and unplanned re-operation after staged open reduction and internal fixation (ORIF) of pilon fractures between cases in which elements of the temporizing external fixator (ex-fix) were prepped into the surgical field and cases in which it was completely removed prior to definitive fixation. Methods: This was a multi-surgeon retrospective comparative cohort study on patients 18 years and older with pilon fractures who underwent operative treatment over a ten-year period between January 1, 2010 to January 1, 2020 at an academic-level 1 trauma center. Medical records and radiographic images were reviewed for each patient to assess demographics, clinical characteristics and surgical outcomes. The primary outcome measures were FRI and unplanned re-operation, including arthrodesis and amputation. All analyses were completed using JMP Software (Version 15.0, SAS Institute Inc., Cary, NC), and an alpha of 0.05 was used for statistical significance. Results: 133 patients underwent staged ORIF, 47 with retained elements of the ex-fix prepped in situ for definitive ORIF and 86 with the ex-fix entirely removed. The overall rate of FRI was 23.3% while the overall rate of unplanned re-operation was 11.3% (4.5% rate of arthrodesis and 6.8% rate of amputation). There was no difference in FRI between the group in which ex-fix was prepped in versus the group in which it was completely removed (23.4% vs 23.3%, p=0.985) and no difference in overall rate of unplanned re-operation (10.6% vs 11.6%, p=0.863). Assessing the subset of patients with FRI, those with ex-fix prepped in had a higher prevalence of infection with MRSA and MSSA (81.8% vs 40%, p=0.021). Using alpha=0.05, and power=0.8, a sample size of 42 patients with FRI post-ORIF (27 with ex-fix prepped in, and 15 with ex-fix removed) would be needed to detect a difference in MRSA/MSSA bacteriology. Conclusion: Although there were relatively high complication rates in this cohort of pilon fractures treated with staged ORIF, prepping in elements of the external fixator did not lead to a significant increase in rates of fracture-related infection nor unplanned re-operation, including arthrodesis and amputation. This study offers clinical support regarding a common practice used to assist in reduction and definitive fixation of distal tibial pilon fractures.
Myelofibrosis
Authors: Passamonti Francesco , Mora Barbara 
Published: November 2022

Abstract
The clinical phenotype of primary and post–polycythemia vera and postessential thrombocythemia myelofibrosis (MF) is dominated by splenomegaly, symptomatology, a variety of blood cell alterations, and a tendency to develop vascular complications and blast phase. Diagnosis requires assessing complete cell blood counts, bone marrow morphology, deep genetic evaluations, and disease history. Driver molecular events consist of JAK2V617F, CALR, and MPL mutations, whereas about 8% to 10% of MF are “triple-negative.” Additional myeloid-gene variants are described in roughly 80% of patients. Currently available clinical-based and integrated clinical/molecular-based scoring systems predict the survival of patients with MF and are applied for conventional treatment decision-making, indication to stem cell transplant (SCT) and allocation in clinical trials. Standard treatment consists of anemia-oriented therapies, hydroxyurea, and JAK inhibitors such as ruxolitinib, fedratinib, and pacritinib. Overall, spleen volume reduction of 35% or greater at week 24 can be achieved by 42% of ruxolitinib-, 47% of fedratinib-, 19% of pacritinib-, and 27% of momelotinib-treated patients. Now, it is time to move towards new paradigms for evaluating efficacy like disease modification, that we intend as a robust and unequivocal effect on disease biology and/or on patient survival. The growing number of clinical trials potentially pave the way for new strategies in patients with MF. Translational studies of some molecules showed an early effect on bone marrow fibrosis and on variant allele frequencies of myeloid genes. SCT is still the only curative option, however, it is associated with relevant challenges. This review focuses on the diagnosis, prognostication, and treatment of MF.
Using Blue Mini-LEDs as a Light Source Designed a Miniaturized Optomechanical Device for the Detection of Direct Bilirubin
Authors: Ye Zhi Ting , Kuo Hsin-Ching , Tseng Shen Fu , Chung Shu-Ru , Tsou Shang-Xuan 
Published: November 2022

AbstractThis study developed a miniaturized optomechanical device (MOD) for the feasibility study of direct bilirubin in urine using high-collimation blue mini-light-emitting diodes (Mini-LEDs) as the light source. The constructed MOD used optical spectroscopy to analyze different concentrations of direct bilirubin using the absorbance spectrum to achieve a noninvasive method for detection. The experimental results showed that between the absorbance and different concentrations of direct bilirubin at the blue Mini-LEDs central wavelength (462 nm) was the optimum fitting wavelength; in the direct bilirubin concentration range from 0.855 to 17.1 μmol/L, the coefficient of determination (R2) was 0.9999, the limit of detection (LOD) of 0.171 μmol/L, and the limit of quantitation (LOQ) of 0.570 μmol/L. Therefore, we propose using blue Mini-LEDs as a light source to design a MOD to replace the invasive blood sampling method with a spectroscopic detection of direct bilirubin concentration corresponding to absorbance.
Epididymal adenomatoid tumor: a case report and literature review
Authors: Efared Boubacar , Boubacar Idrissa , Soumana Djibo , Bako Aïchatou Balaraba Abani , Coulibaly Idrissa Seriba , Koura Hamadou Halidou , Boureima Habiba Salifou , Nouhou Hassan 
Published: November 2022

Abstract
Background
Adenomatoid tumor is a very rare benign neoplasm of mesothelial origin affecting mainly female and male genital tracts. The diagnosis is challenging as this tumor mimics many differential diagnoses. The current literature offers only some case reports and short series of adenomatoid tumors.

Case presentation
A 47-year-old patient with unremarkable medical history presented for chronic mild pain of the right testis evolving for months. The physical examination shows a palpable right intrascrotal nodule of 10 mm in greatest diameter. The nodule was painful, mobile with firm consistency. The laboratory investigations were within normal limits, the scrotal ultrasonography showed a well-circumscribed predominantly hyperechoic intrascrotal nodule in the right epididymal head with heterogeneous echostructure. Excisional biopsy of the lesion was performed and the histopathological analysis showed a well-circumscribed tumor with microcystic and trabecular architecture made of small interconnected tubules and cysts lined by flattened cells with prominent vacuolization and thread-like bridging strands, consistent with an epididymal adenomatoid tumor. The postoperative course was uneventful and the patient was discharged. Four months after surgical treatment, the patient has no sign of the disease.

Conclusion
Testicular adenomatoid tumors are uncommon benign neoplasms with diagnostic challenge. Adenomatoid tumors arising in epididymis are managed by excisional biopsy with testis-sparing surgery avoiding unnecessary orchidectomy.
BioByGANS: biomedical named entity recognition by fusing contextual and syntactic features through graph attention network in node classification framework
Authors: Zheng Xiangwen , Du Haijian , Luo Xiaowei , Tong Fan , Song Wei , Zhao Dongsheng 
Published: November 2022

AbstractBackgroundAutomatic and accurate recognition of various biomedical named entities from literature is an important task of biomedical text mining, which is the foundation of extracting biomedical knowledge from unstructured texts into structured formats. Using the sequence labeling framework and deep neural networks to implement biomedical named entity recognition (BioNER) is a common method at present. However, the above method often underutilizes syntactic features such as dependencies and topology of sentences. Therefore, it is an urgent problem to be solved to integrate semantic and syntactic features into the BioNER model.ResultsIn this paper, we propose a novel biomedical named entity recognition model, named BioByGANS (BioBERT/SpaCy-GraphAttentionNetwork-Softmax), which uses a graph to model the dependencies and topology of a sentence and formulate the BioNER task as a node classification problem. This formulation can introduce more topological features of language and no longer be only concerned about the distance between words in the sequence. First, we use periods to segment sentences and spaces and symbols to segment words. Second, contextual features are encoded by BioBERT, and syntactic features such as part of speeches, dependencies and topology are preprocessed by SpaCy respectively. A graph attention network is then used to generate a fusing representation considering both the contextual features and syntactic features. Last, a softmax function is used to calculate the probabilities and get the results. We conduct experiments on 8 benchmark datasets, and our proposed model outperforms existing BioNER state-of-the-art methods on the BC2GM, JNLPBA, BC4CHEMD, BC5CDR-chem, BC5CDR-disease, NCBI-disease, Species-800, and LINNAEUS datasets, and achieves F1-scores of 85.15%, 78.16%, 92.97%, 94.74%, 87.74%, 91.57%, 75.01%, 90.99%, respectively.ConclusionThe experimental results on 8 biomedical benchmark datasets demonstrate the effectiveness of our model, and indicate that formulating the BioNER task into a node classification problem and combining syntactic features into the graph attention networks can significantly improve model performance.
Expression of PmACRE1 in Arabidopsis thaliana enables host defence against Bursaphelenchus xylophilus infection
Authors: Xie Wanfeng , Xu Xiaomei , Qiu Wenjing , Lai Xiaolin , Liu Mengxia , Zhang Feiping 
Published: November 2022

AbstractBackgroundPine wilt disease (PWD) is a destructive disease that endangers pine trees, resulting in the wilting, with yellowing and browning of the needles, and eventually the death of the trees. Previous studies showed that theAvr9/Cf-9rapidly elicited (PmACRE1) gene was downregulated byBursaphelenchus xylophilusinfection, suggesting a correlation betweenPmACRE1expression and pine tolerance. Here, we used the expression ofPmACRE1inArabidopsis thalianato evaluate the role ofPmACRE1in the regulation of host defence againstB. xylophilusinfection.ResultsOur results showed that the transformation ofPmACRE1intoA. thalianaenhanced plant resistance to the pine wood nematode (PWN); that is, the leaves of the transgenic line remained healthy for a longer period than those of the blank vector group. Ascorbate peroxidase (APX) activity and total phenolic acid and total flavonoid contents were higher in the transgenic line than in the control line. Widely targeted metabolomics analysis of the global secondary metabolites in the transgenic line and the vector control line showed that the contents of 30 compounds were significantly different between these two lines; specifically, the levels of crotaline, neohesperidin, nobiletin, vestitol, and 11 other compounds were significantly increased in the transgenic line. The studies also showed that the ACRE1 protein interacted with serine hydroxymethyltransferase, catalase domain-containing protein, myrosinase, dihydrolipoyl dehydrogenase, ketol-acid reductoisomerase, geranylgeranyl diphosphate reductase, S-adenosylmethionine synthase, glutamine synthetase, and others to comprehensively regulate plant resistance.ConclusionsTaken together, these results indicate thatPmACRE1has a potential role in the regulation of plant defence against PWNs.
A primary cardiac schwannoma of the right ventricle: a case report and literature review
Authors: Wang Fang , Li Lin , Ma Heng , Chi Xiao-Xiao 
Published: November 2022

Abstract
Background
Primary cardiac schwannoma remains extremely rare and difficult to distinguish from other myocardial tumours. We report a case of cardiac schwannoma that occurred in the lateral wall of the right ventricle and grew in the myocardial walls. It is the third case of schwannoma that occurred in the free wall of the right ventricle. Moreover, we reviewed and summarised the literature for cases involving benign cardiac schwannomas.

Case presentation
We present a case of a 64-year-old woman who presented to our centre with syncope for 1–2 min. Echocardiogram and contrast-enhanced computed tomography subsequently revealed a 2.9 × 1.9 cm homogeneous mass originating from the anterior wall of the right ventricle. The patient underwent thoracotomy to resect the mass, which was pathologically verified as Schwann cell tumour.

Conclusions
This is a rare case added to the limited existing literature on cardiac schwannoma. Comprehensive analysis of various imaging examinations is helpful to determine the extent of the tumour. Complete surgical resection is recommended for similar cases involving cardiac schwannomas, especially when the patient has related symptoms. Patients generally have a good prognosis. The pathogenesis of cardiac schwannoma needs further research in order to prevent and manage this rare lesion.
Effect of posture on anorectal manometric measurements in female patients with fecal incontinence and rectoanal intussusception
Authors: Tsunoda Akira , Takahashi Tomoko , Osawa Ikuko 
Published: November 2022

Abstract
Purpose
This study aimed to investigate the influence of erect position on anorectal manometry in patients with rectoanal intussusception (RAI).

Methods
This was a single center prospective observational study. Eighty female patients with fecal incontinence (FI) who underwent defecography between 1st January 2016 and 30th April 2022 were included. The effect of posture on commonly measured parameters during manometry was assessed in the left-lateral and erect positions. The severity of FI was assessed using FI Severity Index (FISI).

Results
Defecography showed that 30 patients had circumferential RAI (CRAI), and 50 had non-CRAI. There were no significant differences in age, parity, FI type, and FISI scores between the groups. However, FISI scores were significantly lower in 51 patients with passive FI than 12 patients with mixed FI type [21 (8–38) vs. 32 (8–43), P = 0.007]. Endo-anal ultrasound showed no significant difference in the incidence of sphincter defects between the groups. Maximum squeeze pressure was significantly lower in the erect position than in the left-lateral position in the CRAI patients [119 cm H2O (59‒454 cm H2O) vs. 145 cm H2O (65‒604 cm H2O), P = 0.006] however, this finding was not observed in the non-CRAI group and the subgroup of anterior RAI patients. In either group, maximum resting pressure, defecation desire volume, and maximum tolerated volume were significantly higher, while anal canal length was significantly shorter in the erect position than in the left-lateral position, respectively.

Conclusion
Voluntary contraction in female FI patients with CRAI was suppressed in the erect position.