bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic predictors of radical resection of stage I-IIIB non-small cell lung cancer: the role of preoperative CT texture features, conventional imaging features, and clinical features
Authors: Zheng Xingxing , Li Rui , Fan Lihua , Ge Yaqiong , Li Wei , Feng Feng 
Published: December 2022

Abstract
Background
To investigate the value of preoperative computed tomography (CT) texture features, routine imaging features, and clinical features in the prognosis of non-small cell lung cancer (NSCLC) after radical resection.
Methods
Demographic parameters and clinically features were analyzed in 107 patients with stage I-IIIB NSCLC, while 73 of these patients received CT scanning and radiomic characteristics for prognosis assessment. Texture analysis features include histogram, gray size area matrix and gray co-occurrence matrix features. The clinical risk features were identified using univariate and multivariate logistic analyses. By incorporating the radiomics score (Rad-score) and clinical risk features with multivariate cox regression, a combined nomogram was built. The nomogram performance was assessed by its calibration, clinical usefulness and Harrell’s concordance index (C-index). The 5-year OS between the dichotomized subgroups was compared using Kaplan-Meier (KM) analysis and the log-rank test.
Results
Consisting of 4 selected features, the radiomics signature showed a favorable discriminative performance for prognosis, with an AUC of 0.91 (95% CI: 0.84 ~ 0.97). The nomogram, consisting of the radiomics signature, N stage, and tumor size, showed good calibration. The nomogram also exhibited prognostic ability with a C-index of 0.91 (95% CI, 0.86–0.95) for OS. The decision curve analysis indicated that the nomogram was clinically useful. According to the KM survival curves, the low-risk group had higher 5-year survival rate compared to high-risk.
Conclusion
The as developed nomogram, combining with preoperative radiomics evidence, N stage, and tumor size, has potential to preoperatively predict the prognosis of NSCLC with a high accuracy and could assist to treatment for the NSCLC patients in the clinic.
The Effects of a Health Education Curriculum on the Knowledge, Attitudes, and Practices of Primary School Students in Beijing, China toward Health-Related Themes: A Cluster Randomised Control Trial
Authors: Long Xin , Ji Ying , Zhang Hongwei , Zhang Xianan , Xie Lijing 
Published: December 2022

Abstract
Background: Most primary school students in China tend to show low health literacy and low adherence levels to healthy behaviors. Health education based on school has been shown to be effective in past studies, but separate health education curricula are rarely used in Chinese schools. This study evaluates the effects of a school-based health education curriculum on students’ knowledge, attitudes, and practices (or behaviors) (KAP) toward health.
Methods: This study uses a cluster randomised controlled trail. Four primary schools were selected and randomly assigned into a control group (n=165) and intervention group (n=262). A one-semester Health Education Curriculum System (HECS) for senior grade pupils was implemented in the intervention group, and the control group was only given a 1-hour health education lecture. The evaluation was assessed from baseline, post-intervention, and 1 year after intervention by changes in students’ KAP on oral health, screen time, physical activity, and other lifestyle choices. Data were collected through questionnaires and analyzed with SPSS 20.0 using Chi-square and ACNOVA.
Results: We found that the knowledge score increased immediately after intervention with a slight decrease in the follow-up stage, significant adjusted changes (95% CI) between the intervention and control groups in score was 5.83 (5.31 to 6.36) at post intervention and 2.59 (2.04 to 3.14) in 1 year follow-up. The prevalence of health-related behaviors were also enhanced to various extents from 13% to 38% between baseline and the post education stage in the intervention group (P<0.05), and pupils showed higher adherence to health choices than the control group at post-intervention and follow-up (P<0.05).
Conclusion:The current study shows that the health education curriculum can have positive effects on improving primary school students’ health KAP.
Trial registration: The study registered with the Medical Ethics Board of Capital Medical University (Z2019SY063) on October 2019. And retrospectively registered in Chinese clinical trial registry on 07/12/2022 (ChiCTR2200066506).
Point Prevalence Surveys of Antibiotic Prescribing in Children at a Tertiary Hospital in a resource constraint, low- income sub-Saharan African country.
Authors: AKINTAN PATRICIA , Oshun Philip , Osuagwu Chioma , Ola-Bello Olafoyekemi , Fajolu Iretiola , Roberts Alero , Temiye Edamisan , Oyinlola Oduyebo 
Published: December 2022

AbstractBackground Antibiotic resistance has been widely described in children by various pathogens to multiple antibiotics, these have become a global health crisis and an emergency. Factors associated with antibiotic use are both community and hospital based as studies have reported increased use of antibiotics by parents and caregivers as well as health care providers This study aimed to describe prevalence rates of antibiotic prescribing and evaluate antibiotic prescribing practices as well as targets for improving the quality of antimicrobial prescribing in children over time. Method Point prevalence survey of antimicrobial use was performed yearly for 4 years to monitor trends in antimicrobial prescribing., Data from all patients admitted before 8 am on the day of the PPS were included. A web-based application designed by the University of Antwerp was used for data-entry, validation and analysis (http://www.global-pps.com). Results A total of 260 children including 90 (34.6%) neonates and 170 (65.4%) older children were admitted during the four surveys. Overall, 179 (68.8%) patients received at least one antibiotic. In neonates, the prevalence of antibiotic use increased from 78.9–89.5% but reduced from 100–58.8% in older children. There was a reduction in the use of antibiotics for prophylaxis from 45.7–24.6%. The most frequently prescribed antibiotic groups were third generation cephalosporins and aminoglycosides. The most common indication for antibiotic prescribing was sepsis in neonates and central nervous system infection in older children. The documentation of reason in notes increased from 33–100% while stop review date also increased from 19.4–82.1%. Conclusion The prevalence of antibiotic use was high with cephalosporins being the most prescribed antibiotic.
Distinct neuronal populations mediate parenting and infanticide in the amygdalohippocampal area
Authors: Sato Keiichiro , Okuno Hiroyuki , Kitamura Kazune , Bito Haruhiko , Suzuki Yutaka , Minami Masabumi , Amano Taiju 
Published: December 2022

Abstract
Male animals exhibit positive and negative infant-directed behaviors, yet the underlying neural mechanisms remain unknown. The amygdalohippocampal area (AHi) regulates social behavior through neural projections to multiple brain regions. Although AHi neurons that project to the medial preoptic area (MPOA) were reported to promote infanticide in male mice, MPOA-projecting AHi neurons are activated by both parenting and infanticide, suggesting heterogeneity within these neurons. Here using a newly developed, virus-mediated projection-specific and activity-dependent cell labeling method (vPAL), we uncovered two distinct functional, electrophysiological, and transcriptional populations in MPOA-projecting AHi neurons, designated infanticide-related and parenting-related neurons. Furthermore, activation of serotonin receptor 7, which is highly expressed in parenting neurons, selectively suppressed infanticide while promoting parenting in virgin male mice. This study provides a better understanding of the neuronal populations, functions, and properties that previous labeling methods masked.
The impact of the two-year Covid-19 pandemic on hospital readmissions to a child and adolescent neuropsychiatric unit
Authors: Raffagnato Alessia , Miscioscia Marina , Bruni Gaia , Col Lara Del , Traverso Annalisa , Tascini Benedetta , Rossaro Maria Paola , Zanato Silvia , Gatta Michela 
Published: December 2022

Abstract
Background
Since2020 Italy and the world have been facing the health emergency related to the COVID-19 pandemic. Increasing evidence supports the association between the COVID-19 pandemic and the worsening mental health conditions of children and adolescents, with increased accesses in Emergency Departments and hospitalizations for psychiatric problems. This paper aimed to (a) study the population of patients admitted to a Neuropsychiatric Hospital Unit of North Italy during the pandemic two-year period, throughout a comparison with the population of patients hospitalized in the previous two years, according to socio-demographic and clinical variables (b) analyse the hospital readmission phenomenon, which has apparently increased its frequency during the first pandemic year according to recent studies.
Methods
This is an observational retrospective cohort study about 375 hospitalised patients from February 2018 to March 2022 due to neuropsychiatric problems. Data wereanalysed through mean, standard deviation, percentages, t-tests, chi-squared test, Fischer’sand non-parametric Mann-Whitney U-test. The level of statistical significance was set at p ≤ 0.05.
Results
Risk factors for mental health disorders were similar between the two groups, except for the significantly increased use of electronic devices in the COVID-19 one. Patients suffering from eating disorders tripled over time. Hospital readmissions almost doubled between the pre-COVID-19 two-year period and the COVID-19 period: 75% of patients hospitalized three or more times in the last two years and 85.7% of the so called “revolving door “patients (with relapse within three months after discharge) both belonged to the COVID-19group. The comparison between the two groups of patients readmitted before and during the COVID-19 pandemic didn’t show any differences in terms of socio-demographic and clinical characteristics.
Conclusions
These results suggest the inadequacy of local neuropsychiatric services in managing the complexity of clinical situations and the necessity to implement prevention strategies and services.
Dose DIP control medical expenses and suit for China ：evidence from Guangzhou in China
Authors: zhang mengjun , Liu Jing , Chen Yunshan , Ma Luning , Wu Zhiming , Xiang Guochun 
Published: December 2022

Abstract
Background China's health spending has surged in the past five years, rising from 1,315.9 billion yuan to 1,754.5 billion yuan, an average annual growth rate is 7.5%. In order to control the excessive growth of medical expenses, China proposed Diagnosis-Intervention Packet (DIP) and DRGs payment methods based on local conditions, DIP was piloted in Guangzhou in 2018. The purpose of this study is to better provide evidence for the development of medical payment methods and also provide policy information for the development of medical insurance payment methods to support the promotion of DIP.
Methods The data were collected from the medical expenses of inpatients provided by the Medical Insurance Department of a tertiary hospital in Guangzhou. SPSS 26.0 software was used to calculate the average hospitalization cost (AHC), proportion of nursing expenses (PNE), proportion of medicines fees (PM), proportion of examination fees (PEF), proportion of laboratory fees (PLF), length of stay and average age of inpatients from four dimensions without distinguishing diseases, core diseases, comprehensive diseases and single diseases. The Difference in Difference (DID) model was used to empirically analyze the data, and the robustness was tested.
Results After the implementation of DIP, the growth rate of medical expenses has been controlled. As the cost data for all inpatients, compared with Fee-For-Service (FFS), DIP increased the PNE (β=0.006, p<0.1), and decreased PM(β=-0.051, p<0.05). From the perspective of core disease dimension, DIP decreased PEF (β=-0.015, p<0.05) and PM (β=-0.076, p<0.1). From the perspective of comprehensive diseases, DIP increased PNE (β=0.005, p<0.1). In terms of single diseases, DIP decreased the PEF (β=-0.044, p<0.05) and PLE (β=-0.054, p<0.001). The empirical results passed the equilibrium trend test and the robustness test.
Conclusions DIP is more suitable for China's medical environment. It controls the growth rate of medical service costs, reduces PM, PLF and PEF to varying degrees, changes the structure of medical costs, guides the rational allocation of medical and health resources, and reflects the value of medical personnel services.
Diabetes impairs fracture healing through Foxo1 mediated disruption of ciliogenesis
Authors: Chinipardaz Zahra , Yuan Gongsheng , Liu Min , Graves Dana , Yang Shuying 
Published: December 2022

Abstract
Foxo1 upregulation is linked to defective fracture healing under diabetic conditions. Our previous studies showed that diabetes impairs ciliogenesis resulting in defective fracture repair. However, the mechanism by which diabetes causes cilia loss during fracture healing remains elusive. We report here that streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) dramatically increased Foxo1 expression in femur fractured calluses, resulting in a significant decrease in the expression of IFT80 and primary cilia number. Ablation of Foxo1 in osteoblasts in-vivo (OSXcretTAFoxo1f/f) rescued IFT80 expression and restored ciliogenesis as well as restored bone formation and mechanical strength in diabetic fracture calluses. In-vitro, advanced glycation end products (AGEs) impaired cilia formation in osteoblasts and reduced the production of a mineralizing matrix, which were restored by Foxo1 deletion. Mechanistically, AGEs increased Foxo1 expression and transcriptional activity to inhibit the IFT80 expression causing impaired cilia formation. Thus, our findings demonstrated that diabetes impairs fracture healing through Foxo1 mediated inhibition of primary cilia formation, resulting in impaired osteogenesis. Inhibition of Foxo1 and/or restoration of cilia formation has the potential to promote diabetes-impaired fracture healing.
Immunoinformatics design of novel peptide vaccines against Epstein-Barr virus with over 99% global population coverage: A Reverse Vaccinology approach
Authors: Yousaf Hassan , Naz Anam 
Published: December 2022

Abstract
Background
Epstein-Barr virus is commonly known as human herpes virus 4; an oncovirus belonging to the herpes virus family. The pathogen is extremely ubiquitous and infects more than 90% of population once in a lifetime.
Methods
The current study has employed a computational pipeline to develop a multiepitope vaccine design by targeting the most antigenic glycoproteins of the virus. The proteins were separately processed to retrieve B-cell and T-cell epitopes. The most suitable epitopes were scrutinized to design the peptide vaccine using appropriate linkers and adjuvants. The designed chimeric vaccines were further analyzed for their molecular interactions with TLR-4 and CD21 receptor. Consequently, the structural motion of the docked complexes was analyzed by molecular dynamics simulation approach followed by immune simulation.
Results
Our results showed promising outcomes in terms of vaccine antigenicity, population coverage and significantly lower free binding energies with potential receptors tested on 4 different docking platforms.
Conclusion
The conducted in silico study concludes that peptide vaccines could be a suitable alternative to traditional vaccinology approaches. Hence, our study will aid in the better formulation of vaccines in future by targeting the suitable drug or vaccine candidates.
Characteristics of alpha-fetoprotein-positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing
Authors: Shen Zhanlong , li yansen , Lin Yilin , Zhao Long , Yang Changjiang , Wang Bo , Gao Zhidong , Jiang Kewei , Ye Yingjiang , Wang Shan 
Published: December 2022

Abstract
Background: Gastric cancer is one of the most common malignant tumors worldwide. Patients with alpha fetoprotein (AFP)-positive gastric cancer (AFPP-GC) are considered a special group among gastric cancer cases. At present, there are still controversies about the clinicopathological characteristics and prognosis of AFP-GC, and the potential mechanism of its high malignant potential is still unclear. There is a lack of a comprehensive description of AFPP-GC genome characteristics and regulatory mechanisms.
Methods: This study analyzed the pathological characteristics and prognosis of AFPP-GC through clinical samples. The characteristics of AFP-positive gastric cancer were identified by cross-linking analysis between sequencing data and public databases. To verify the mechanism of AFP positive gastric cancer promoting gastric cancer metastasis.
Results: The results showed that the prognosis of AFPP-GC was poor, with a high risk of liver metastasis. Tissue transcriptome sequencing showed that AFPP-GC high-expression genes were involved in the activation of various cancer pathways, and low-expression genes were involved in the immune response. Single sample gene set enrichment analysis showed that overexpression of APF in AFPP-GC significantly inhibited the infiltration of CD8+ T cells. To further explore the genomic characteristics of AFPP-GC, the signaling pathway by whichAFP regulatesthe invasion and metastasis of AFPP-GC cells was discussed. The results showed that AFPP-GC may promote cell invasion by regulating thePTEN/ATK1/SOX5/CES1 signalingaxis. This study reveals the molecular mechanism by whichAFPP-GC has higher malignant potential than AFPN-GC. This finding provides an important strategy for the individualized treatment of AFPP-GC.
Soil Micromorphology for Modeling Spatial on Landslide Susceptibility Mapping
A Case Study in Kelara Subwatershed, Jeneponto Regency of South Sulawesi, Indonesia
Authors: Ahmad Asmita , Farida Meutia , Juita Nirmala , Jayadi Muh 
Published: December 2022

Abstract
Most of the results of classifying the level of susceptibility show different results, where landslides are more common in areas with a relatively high to moderate susceptibility class compared to those with a high susceptibility class. Differences in methods result in differences in the susceptibility maps resulting from the parameters that cause the tested landslides. The Spatial Regression Model can precisely interpret the relationship between several landslide parameters and events and shows better data accuracy than other methods. Utilization of soil micromorphological parameter data in mapping the level of susceptibility of the soil that triggers landslides with a Spatial Regression model so that the resulting susceptibility map can be more accurate. The soil parameter test method was carried out using a split-plot design with land use as the main plot, slope as a sub-plot, and soil physics (permeability, bulk density, and porosity) as a sub-sub-plot with three replications. Spatial modeling is done through regression analysis using ordinary least squares. The first test analysis was carried out with general parameters: lithology, rainfall, slope, land cover/land use, and population, while the second test was with parameters: lithology, rainfall, slope, land cover/land use, population, soil organic carbon, texture, erodibility and soil micromorphology. Classification of vulnerable classes using the natural breaks method. The interaction between the type of land use, slope, and physical properties of the soil on the occurrence of landslides at the study site shows a strong relationship with a significant p-value = 0.043 less than the α 5% level. Increased land use by the community has triggered the formation of soil micromorphology in the form of plane voids, cross-striated and grano-striated, which can trigger internal shifts (micro-shifts) in the soil body. The landslide susceptibility map at the study site is divided into seven spatial susceptibility classes: extremely low, very low, low, moderate, high, very high, and extremely high. Spatial modeling with OLS shows that the independent factors in the form of lithology, rainfall, slope, land cover/land use, and population only get an R2 value of 30.8%. Adding landslide independent parameter data in the form of soil organic carbon factor, texture, erodibility, and soil micromorphology produces a spatial model of landslide susceptibility with an increase in the accuracy value of R2 by 66.66%. The spatial model shows a high level of consistency with very significant soil micromorphology at a p-value < 0.01. The resulting spatial model is more accurate, where the high susceptibility class has a more significant number of landslide events, and landslides decrease according to the class.
Prevalence and Influence on Prognosis of Mental Health Comorbidities in Long-term Breast Cancer Survivors: Results From the Surbcan Study
Authors: Padilla-Ruiz María , Gimeno-Miguel Antonio , Rivas-Ruiz Francisco , Martínez-Casanova Mª Carmen , Jansana Anna , Prados-Torres Alexandra , Poblador-Plou Beatriz , Cura Isabel Del , Sanz-Cuesta Teresa , Ibáñez Berta , Castells Xavier , Sala María , Redondo Maximino 
Published: December 2022

Abstract
Aim
The increase in survival of patients with breast cancer has largely been due to early detection and treatment advances, which has led to longer follow-up and treatment of these patients. The principal aim of this work is to describe the presence of mental health comorbidities and analyze their influence on survival in women who are long-term breast cancer survivors.
Methods
This retrospective multicenter cohort study is part of the SURBCAN Study, a cohort of 4,088 women who are long-term breast cancer survivors diagnosed between 2000 and 2006 who were followed-up on between 2012 and 2016. A descriptive analysis of the study population’s characteristics and prevalence of mental health comorbidities was performed. A Cox regression analysis was performed to study the influence of mental health comorbidity on all-cause mortality.
Results
A total of 42.2% of patients presented with at least one mental health comorbidity, notable among which were anxiety disorders and depression and mood disorders, with a prevalence of 37.6% and 21.1%, respectively. The presence of a mental health comorbidity was associated with a poor prognosis (HR: 2.13; 95% CI: 1.70–2.66), as was more advanced tumor stages.
Conclusions
The presence of mental health comorbidities in women who are long-term breast cancer survivors is associated with lower survival. Individualized follow-up in which the patient’s mental health status is specifically monitored is recommended.