bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIRT3-mediated deacetylation of SDHA rescues mitochondrial bioenergetics contributing to neuroprotection in rotenone-induced PD models
Authors: Shen Yanhua , Wang Xueting , Nan Nan , Fu Xiaolong , Zeng Ru , Yang Yonggang , Xian Siting , Shi Jingshan , Wu Qin , Zhou Shaoyu 
Published: July 2022

Abstract
Mitochondrial dysfunction is critically involved in the degeneration of dopamine (DA) neurons in the substantia nigra (SNc), a common pathological feature of Parkinson’s disease (PD). Previous studies have demonstrated that the NAD+-dependent acetylase Sirtuin 3 (SIRT3) participates in maintaining mitochondrial function and is downregulated in aging-related neurodegenerative disorders. The exact mechanism of action of SIRT3 on mitochondrial bioenergetics in PD pathogenesis, however, has not been fully described. In this study we investigated the regulatory role of SIRT3-mediatged deacetylation of mitochondrial complex II (succinate dehydrogenase) subunit A (SDHA) and its effect on neuronal cell survival in rotenone (ROT)-induced rat and differentiated MN9D cell models. The results revealed that SIRT3 activity was suppressed in both in vivo and in vitro PD models. Accompanying this downregulation of SIRT3 was the hyperacetylation of SDHA, impaired activity of mitochondrial complex and decreased ATP production. It was found that the inhibition of SIRT3 activity was attributed to a reduction in the NAD+/NADH ratio caused by ROT-induced inhibition of mitochondrial complex I. Activation of SIRT3 by icariin and honokiol inhibited SDHA hyperacetylation and increased complex II activity, leading to increased ATP production and protection against ROT-induced neuronal damage. Furthermore, overexpression of SDHA also exerted potent protective benefits in cells treated with ROT. In addition, treatment of MN9D cells with the NAD+ precursor nicotinamide mononucleotide increased SIRT3 activity and complex II activity and promoted the survival of cells exposed to ROT. These findings unravel a regulatory SIRT3-SDHA axis, which may be closely related to PD pathology. Bioenergetic rescue through SIRT3 activation-dependent improvement of mitochondrial complex II activity may provide an effective strategy for protection from neurodegeneration.
Multi-sensor Tracking with Partly Overlapping FoV Using Detection Field of Probability Modeling and the GLMB Filter
Authors: Weifeng Liu , Liu Qiliang , Chen Yimei , Cui Hailong 
Published: July 2022

Abstract
In this paper, we consider multi-sensor with partly overlapping field of view (FoV) in the labeled random finite set (L-RFS) framework. This is different from most existing multi-sensor tracking algorithms, where the sensors are assumed to have the same FoV. We describe the partly overlapping FoV by modeling probability field of detection (PFoD) for individual sensors in whole observation area and can be seen as the same range of FoV. We consider all these using generalized labeled multi-Bernoulli (GLMB) filter in labeled RFS framework. Besides, a multi-sensor measurement driven of birth model is proposed. Finally, the effectiveness of the proposed algorithm is verified by experiments.
Photocatalytic degradation of tetracycline hydrochloride by novel Fe3O4/g-C3N4/rGO magnetic nanocomposites mechanism: modeling and optimization
Authors: Shan Junyue , Wu Xianliang , Li Caifang , Hu Jiwei , Zhang Zhenming , Liu Huijuan , Xia Pinhua , huang xianfei 
Published: July 2022

Abstract
The photocatalytic degradation of antibiotics requires a good separation efficiency of photogenerated electron-hole pairs and a wide visible light absorption range. Current studies have discussed the successful preparation of ferroferric oxide/graphite carbon nitride/reduced graphene oxide (Fe3O4/g-C3N4/rGO). The phase structure and morphology of Fe3O4/g-C3N4/rGO composites were characterized by XRD, HR-TEM, SEM and EDS. The obtained composites were used to degrade tetracycline hydrochloride to evaluate its photocatalytic activity. The effects of four variables on the degradation of tetracycline hydrochloride were analyzed by the response surface method and artificial intelligence (gradient regression tree, random forest, artificial neural network, etc.). The results showed that the graphite carbon nitride in the catalyst maintained its original structure and that the photocatalytic activity was significantly improved. The degradation rate of tetracycline hydrochloride was 86.7%. The artificial neural network combined with a genetic algorithm was the best model for predicting the degradation of tetracycline hydrochloride by nanocomposites. The degradation of tetracycline hydrochloride was in accordance with the pseudosecond-order kinetic model. The proposed photocatalytic mechanism study indicated that ∙O2− and ∙OH radicals are the foremost reactive species that have vital roles in the photodegradation process. This finding provides a theoretical reference for the photocatalytic degradation of antibiotics (or analogous pollutants) in wastewater.
Preventing the Next Pandemic: A Critical Analysis of the Utilization of Artificial Intelligence in the U.S. Healthcare System
Authors: Howington Jabria , Andrade MPH DrPH Elizabeth 
Published: July 2022

Abstract
The outbreak of 2019-nCoV (“COVID-19”) raised major concerns as it spread rapidly around the globe. The impacts are not fully known and cannot be overlooked given the emergence of COVID-19 variants. In response to this ever-changing virus, artificial intelligence (“AI”) has been explored for its capability to combat the pandemic. This critical analysis examines the utility of AI to improve pandemic preparedness and discusses the benefits of AI-based technologies, such as detecting disease outbreaks, mitigating spread, and speeding drug and vaccine development. It also questions whether AI applications could prevent the next pandemic.A literature search was performed using PubMed, MEDLINE, and Scopus, and articles published after January 2020 that discussed AI applications in the U.S. healthcare system were ranked in terms of relevance on a scale of 1-5 according to their degrees of focus. Articles scoring three or higher were included in the final literature review. From a total of forty-one identified articles, twenty-four met the inclusion criteria and twelve were ranked of highest relevance by including discussions on AI models and methods, the strengths and limitations, and promising practice or recommendations.This critical analysis concludes that AI-based technology is successful at improving pandemic preparedness, but challenges and limitations will arise as we continue to invest in AI-based technology; such as over- or under-performance due to imbalanced or incomplete data. Overall, the utilization of AI should aim to improve emergency preparedness strategies, mitigation efforts, and vaccine development, while alleviating the burdens experienced by medical professionals to achieve the best results.
Rotation compensation algorithm of Multi-Orthogonal Signal Underwater Navigation System of moving platform
Authors: zhang sen , zhou chenlin , yin tian qi , wang mingzhi 
Published: July 2022

Abstract
When the transmitter of Multi-Orthogonal Signal Underwater Navigation System(MOSUNS) is installed on a moving platform, the rotation of the platform leads to positioning error. In order to solve this problem, the motion error modeling is carried out in this paper, the relationship platform motion parameters (translation rate, rotation rate, etc.) and the linear velocity difference between each transmitter element and the phase error is deduced, and the relationship between the positioning error of the MOSUNS and the platform motion parameters is further deduced. Based on the motion error modeling of moving platform, a rotation compensation algorithm was proposed to compensate the phase error caused by platform rotation, and then the positioning error was compensated. The motion error modeling is quantified by computer simulation, and the validity of the phase compensation algorithm is verified by simulation.
The effect of street environment on two types of essential physical activity in industrial neighborhoods from the perspective of public health: a study from the Harbin Low-Income Population Health Survey, China
Authors: Hou Yunjing , Zhai Chaofan , Chen Xiyu , Li Wen 
Published: July 2022

Abstract
A large number of low-income residents in industrial neighborhoods rarely go out for recreational and physical activities in green spaces during extremely cold weather. This study mainly explores the relationship between street environment and physical activities under special industrial properties and extreme cold weather conditions.In addition, we further divided essential physical activity into two categories, life-type and traffic-type physical activity, to explore and refine the related studies. We use principal component analysis to classify the street environment indicators, and use multiple linear regression to analyze the impact of each indicator on different physical activities.The conclusions are as follows. For low-income people, the street environment in industrial neighborhoods has a much greater impact on life-type physical activity than traffic-type physical activity and that there is a conflict between the two. In addition, high greening density is not conducive to either type of physical activity on the street. This will reduce the paved area of streets and create sports conflicts between people undertaking different physical activities. The findings contribute to the development and optimization of public health research on environmental interventions in industrial neighborhood streets and enable effective recommendations for increasing outside physical activity among low-income people in severe weather conditions.
Prevalence of Secondary Hyperparathyroidism in Adult Chronic Hemodialysis Patients in Somalia
Authors: Bashir Ahmed Muhammad , Alici Gokhan , Wabari Mohamud Mire , Adani Abdulkamil Abdullahi , Ahmed Hussein Mahdi 
Published: July 2022

Abstract
Background: Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD). Aim: The exact prevalence of secondary hyperparathyroidism in chronic hemodialysis patients in Somalia is unknown. In this study, we aimed to determine the prevalence of SHPT in chronic hemodialysis patients in Mogadishu, Somalia.Method: This retrospective analysis was carried out at the Mogadishu Somali Turkey Training and Research Hospital, Somalia’s largest dialysis center. All hemodialysis patients aged 18 years and older from the last year were included. The research excluded parathyroidectomy patients and patients on steroids, phenytoin, or phenobarbitone. This analysis covered 195 patients. Calcium, phosphate, albumin, vitamin D, urea, creatinine, and other electrolytes were tested.Results: The mean age of the 195 patients was 56.0±17.4, with 49.2% males and 50.88% females. End-stage kidney disease (ESKD) was caused by hypertension in 64.1% of the patients and diabetes in 30.8%. The mean hemodialysis time was 7.8±1.3 hours per week, and the mean duration was 39.6±15 months. The mean intact parathyroid hormone (iPTH) concentration was 458.59±636.96 pg/mL, phosphate was 4.24±2.15 mg/dL, corrected calcium was 8.70±0.97 mg/dL, and calcium phosphate product was 36.60±19.78 mg/dL. The mean vitamin D concentration was 33.53±19.70. We found that the prevalence of secondary hyperparathyroidism was 65.6%.Conclusion: We conclude that there is a high prevalence of secondary hyperparathyroidism in chronic hemodialysis patients in Somalia and that measures that predict vitamin D response, including sestamibi parathyroid scans and gland volume, should be studied further to prevent this high prevalence.
Variational Autoencoder-based Estimation of Chronological Age and Changes in Morphological Features of Teeth
Authors: Joo Subin , Jung Won , Oh Seung Eel 
Published: July 2022

Abstract
The present study developed a variational autoencoder (VAE) capable of estimating the chronological age of subjects using feature values extracted from their teeth, and further determine how given teeth images affected the accuracy of estimation. The developed VAE was trained with first molar and canine teeth images, and a parallel-VAE structure was further constructed to extract common features shared by the two types of teeth in a more effective manner. The encoder of the VAE was designed to be combined with a regression model to estimate age. In an attempt to determine which parts of tooth images were more or less important when estimating age, a method of visualizing the obtained regression coefficient using the decoder of the VAE was developed. The developed age estimation model was trained with data obtained from a total of 910 individuals aged 10–79 years. This model showed a median absolute error (MAE) of 6.99 years, demonstrating its ability to estimate age accurately. Further, this method of visualizing the influence of particular parts of tooth images on the accuracy of age estimation using a decoder is expected to provide novel insights for future research on explainable AI.
CT, MRI, and 18 F-FDG PET/CT imaging features of seven cases of adult pancreatoblastoma
Authors: Wu Meng-nan , Lin Jiong-bin , Liu Zhuang-sheng , Huang Zhi-ming , Wang Ruo-ning 
Published: July 2022

Abstract
Objective: This study mainly analysed the imaging data of seven cases of adult Pancreatoblastoma (PB) and summarized additional imaging features of this disease based on a literature review, aiming to improve the understanding and diagnosis rate of this disease.Material and Method: The imaging data of seven adult patients pathologically diagnosed with adult PB were retrospectively analysed.Results: The tumours were located in the head of the pancreas in three cases, in the tail of the pancreas in two cases, in the gastric antrum in one case, and in the whole pancreas in one case. Six tumours showed restricted, bifurcated, and extruded growth, and one tumour displayed diffuse growth in the whole pancreas. Seven tumours appeared isoattenuating on Non-contrast CT, two tumours appeared isointense on T1WI and hyperintense on T2WI MRI sequences, six tumours exhibited necrosis and cystic in the centre, and one tumour was solid and contained immature bone. The seven tumours had ill-defined margins and no capsule. Four tumours showed evident enhancement with a fast-in and slow-out pattern on contras-CT and MRI scans, and two tumours displayed mild enhancement with a slow-in and slow-out pattern . 18F-FDG PET/CT imaging exhibited high uptake in five pancreatic tumours.Conclusion: Adult PB cells can differentiate into cells of osteocytes systems. Extrusive growth is much more common than diffuse growth. An ectopic pancreas can also develop PB and pancreatic duct dilatation. On contrast-enhanced CT and contrast-enhanced MRI scans, tumours may show evident enhancement or mild enhancement. 18F-FDG PET/CT imaging exhibited high uptake.
Association between Social Support and Healthy Aging in Older Japanese: The Ohsaki Cohort 2006 Study
Authors: Nakayama Aiko , Lu Yukai , Matsuyama Sanae , Otsuka Tatsui , Tanji Fumiya , Tsuji Ichiro 
Published: July 2022

Abstract
Background
Healthy aging has attracted a great deal of attention worldwide with the progression of aging societies. However, few studies have investigated the association between social support and healthy aging. Thus, our study aimed to examine the association of emotional and instrumental social support with healthy aging among older Japanese adults.
Methods
This community-based prospective cohort study was conducted in Ohsaki City, Japan, and included 8,232 people aged ≥ 65 years at the baseline survey in 2006. Based on information obtained from this survey, participants were categorized according to two types of social support: having / lacking emotional social support and having / lacking instrumental social support. The primary outcome was healthy aging (defined as meeting all four of the following criteria: free of disability, free of depression, high health-related quality of life and high life satisfaction), as assessed by a questionnaire survey carried out in 2017. Multiple logistic regression was used to calculate the corresponding odds ratios (ORs) and 95% confidence intervals (95%CIs).
Results
During approximately 11 years of follow-up, 620 (7.5%) participants attained healthy aging. Compared with participants lacking emotional social support, the multivariable-adjusted OR (95%CI) was 1.60 (1.12–2.29) for those having emotional social support. Compared with participants lacking instrumental social support, the multivariable-adjusted OR (95%CI) was 1.71 (1.32–2.23) for those having instrumental social support. Furthermore, we found that the likelihood of healthy aging was significantly higher in the group that had both types of social support, but not in those with only one compared with those having neither type of social support.
Conclusions
These findings suggest that both emotional and instrumental social support are associated with healthy aging of older people in Japan.
The broad reach and inaccuracy of men’s health information on social media: analysis of TikTok and Instagram
Authors: Dubin Justin , Aguiar Jonathan , Lin Jasmine , Greenberg Daniel , Keeter Mary , Fantus Richard , Pham Minh , Hudnall Matthew , Bennett Nelson , Brannigan Robert , Halpern Joshua 
Published: July 2022

Abstract
Objectives: To quantify the volume and characterize the accuracy of men’s health-related content on TikTok and Instagram Methods: We conducted a search on both TikTok and Instagram for the terms: testosterone, erectile dysfunction, male infertility, semen retention, Peyronie’s disease, and vasectomy. The top 10 hashtags for each term were identified and used to estimate the total number of impressions for each term on each platform. We evaluated the top 40 posts for each topic on each platform and characterized the post by creator type, content type, and accuracy. Content accuracy was scored on a scale from one to five, with one being completely inaccurate information and five being completely accurate.Results: Overall, TikTok had more than 2.3 billion impressions and Instagran had more than 3 million posts across the men’s health topics. Semen retention had the most impressions on TikTok (1.2 billion) and posts on Instagram (1 million). Physicians created only a small portion of content comprising only 10.3% and 12.9% of total TikTok and Instagram posts, respectfully. Across all men’s health topics, the accuracy of content was poor with a score of 2.6 +/- 1.7 but physician posts were significantly more accurate than non-physician posts (4.2 vs 2.3, p < 0.001 respectfully).Conclusions: Men’s health content is popular on TikTok and Instagram but has a low level of overall accuracy. Given the higher accuracy of physician-created content, we recommend that physicians actively engage, on both individual and organizational levels, in social media to address misinformation
Dual Medication Therapy (Acetaminophen and Ibuprofen) for the Management of Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis
Authors: Shah Sanket , Makker Kartikeya , Zhang Mingyu , Harnett Susan , Aziz Khyzer , Hudak Mark 
Published: July 2022

Abstract
Objective: To examine the efficacy of dual medication therapy (DMT: acetaminophen and ibuprofen) vs. single medication therapy (SMT: ibuprofen) for medical management of PDA.Study Design: We systematically searched multiple sources to identify randomized controlled trials (RCT) and non-randomized studies (NRS) that compared DMT to SMT for management of hemodynamically significant PDA. Results: We identified two RCTs and four NRS. There were no differences in the rates of successful PDA closure following the first treatment course between DMT and SMT (RR = 1.23 [95% CI 0.89 to 1.70] for NRS and RR = 1.18 [95% CI 0.66 to 2.10] for RCTs), nor were there significant differences in secondary outcomes and adverse events including PDA ligation, bronchopulmonary dysplasia, severe intraventricular hemorrhage, and necrotizing enterocolitis. etc. Markers of hepatic or renal function did not change significantly during PDA treatment.Conclusion: We found no evidence for superiority of DMT over SMT in PDA management.
Perceptions of being a Registered Nurse (PRN): Development and validation of a survey tool
Authors: Allen Louise Margaret , Cooper Simon , Missen Karen Lee 
Published: July 2022

Abstract
Background
Nursing students need to develop realistic perceptions of nursing to prepare them for employment. Perceptions of nursing survey tools are available but lack contemporary cultural foci.
Aim
To develop a feasible, valid and reliable survey tool to identify nursing student’s perceptions of being a nurse with the objective of identifying key influences on perceptions.
Design/Methods:
In Phase 1 a literature review, and Nominal Group Technique meetings was used to generate primary survey items. Phase 2 included a pre-pilot and online pilot testing of the Perceptions of being a Registered Nurse (PRN) survey tool with 797 nursing students, across all year levels at three Australian Universities.
Results
The 34-item PRN survey tool uses a five-point Likert scale to measure nursing students’ perceptions of nursing including personal impact, attributes, the nursing role and professionalism. The Item-Content validity index was high (> .78) and the inter-item correlation validity was identified by a Pearson’s product moment co-efficient of r = .712. Internal reliability was confirmed with a Cronbach’s alpha = .83. Based upon the participation completion rate, the survey tool was deemed applicable and feasible. The majority of respondents believed that nurses had altruistic attributes however perceptions of nursing varied significantly when rating the physical, emotional and social impacts of being a nurse. Further, in later stages of training, respondents were more likely to agree that nursing is physically and emotionally demanding, that nurses experience social isolation due to shift work and find it difficult to achieve a work-life-balance.
Conclusions
The PRN survey tool was found to be valid, reliable and feasible. Future use and outcomes from PRN assessments may inform nursing curricula and will lead to enhanced perceptions of nursing.
Stem cell-derived small extracellular vesicles containing miR-27b-3p attenuated osteoarthritis by targeting leukaemia inhibitory factor expression of synoviocytes
Authors: Tong Wei , Zhang Xiaoguang , Chen Wei , Lan Shenghui , Hu Yuxiang , Pei Hongxin , He Zhili , Dai Zhipeng , Wei Yulong , Wang Zhenxing , Ma Qinyu , Zhao Fenfei , Wang Juan , Shao Zengwu , Liu Yong , Yang Shuhua , Tian Hongtao 
Published: July 2022

Abstract
Mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) have been demonstrated to be effective in the treatment of OA, but the precise target cells and response mechanisms are not well characterised. In this study, first, we found that intra-articular injection of human umbilical cord MSC (UCMSC)-derived sEVs (U-sEVs) significantly alleviated mouse OA. Then, U-sEVs were taken up rapidly and preferentially by fibroblast-like synoviocytes (FLSs) in a mouse model. Furthermore, significant increase in miR-27b-3p in FLSs after U-sEV treatment were found by miRNA sequencing, identifying miR-27b-3p as a key cargo of U-sEVs. Bioinformatics and luciferase reporter found that leukaemia inhibitory factor (LIF) is the target gene of miR-27b-3p, and single-cell RNA-sequencing (scRNA-seq) and RNA-sequencing revealed that LIF could directly induce synovitis, possibly by promoting proinflammatory cytokine and MMPs expression. Lastly, both miR-27b-3p and miR-27b-3p-overexpressing U-sEVs inhibit the expression of LIF in FLSs, and accordingly exhibited stronger effects in mitigating synovitis and OA progression compared to control U-sEVs. In conclusion, our results revealed that the main recipient cell of U-sEVs in the joints are FLSs. Mechanistically, miR-27b-3p in U-sEVs inhibited LIF expression of FLSs, and thus inhibited synovitis and delayed OA.