bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green Synthesis of Trimetallic Oxides of Mn, Cu, Zn Using Rose Petals and their Antimicrobial Activity
Authors: Gillani Syeda Shaista , Khan Sana Abbas , Nazir Rabia , Qurashi Aisha waheed 
Published: March 2022

Mixed metal oxides (CuO, ZnO, and MnO) nanoparticles (NPs) were synthesized by the green process which is simple, cost-effective, eco-friendly, and non-toxic. In the green synthesis method, rose petals extracts were used as a reducing and capping agent while salt solutions (CuCl2, MnCl2, and ZnSO4) were used as a precursor that lead to the formation of mixed metal oxides (CuO, ZnO, MnO) NPs. UV-Visible and FTIR spectroscopy were used for the analysis of mixed metal oxides (CuO, ZnO, MnO) NPs, which showed maximum absorbance in the range of 280 to 370 nm. The presence of particular peaks in FTIR verified the synthesis of mixed metal oxide nanoparticles. The antimicrobial and antifungal activities of mixed metal oxides (CuO, ZnO, MnO) NPs were carried out by the disc diffusion method and well diffusion method. Mixed metal oxides (CuO, ZnO, MnO) NPs showed antimicrobial activity against Escherichia coli and antifungal activity against Candida albicans, Curvularia lunata, Aspergillus niger, and Trichophyton simii. So, these mixed metal oxides (CuO, ZnO, MnO) NPs can be effective in the pharmaceutical sector.
Keywords: antifungal, antimicrobial, green synthesis, mixed metal oxides nanoparticles (MONPs), rose petals extracts
Copyright (c) The Authors
Критерії сформованості професійно-­комунікативного іміджу іноземних студентів медичних спеціальностей
Authors: Кушнір Ірина 
Published: March 2022

Стаття висвітлює проблему пошуку діагностичного інструментарію для визначення результату мовної підготовки іноземних студентів у ЗВО України. Сьогодні спостерігаємо зростання чисельності іноземних студентів, які здобувають вищу освіту в українських вишах англійською мовою. Навчання української мови як іноземної англомовних здобувачів вищої медичної освіти закладає лінгвістичний базис професійно-­комунікативного іміджу майбутніх лікарів. У статті виокремлено критерії та описано показники, за якими можна діагностувати рівень сформованості психологічного, когнітивно-­комунікативного та когнітивно-­мовного складників професійно-­комунікативного іміджу. Застосування описаних критеріїв для оцінки рівня сформованості ПКІ іноземних студентів-­медиків дозволить порівняти характеристики необхідного результату вивчення освітніх дисциплін лінгвістичного циклу з реальними показниками сформованості мовних навичок та мовленнєвих умінь іноземних здобувачів.
PENGARUH KARAKTERISTIK DEWAN KOMISARIS DAN DEWAN DIREKSI TERHADAP KINERJA KEUANGAN
Authors: Lestari Tika , Mutmainah Kurniawati 
Published: March 2022

Penelitian ini bertujuan untuk mengetahui pengaruh dari gender diversity, age diversity, tenure diversity, dan etnis Tionghoa pada komposisi dewan komisaris dan dewan direksi terhadap kinerja keuangan. Sampel dalam penelitian ini berjumlah 48 laporan tahunan perusahaan manufaktur industri barang konsumsi yang terdaftar di Bursa Efek Indonesia (BEI) periode tahun 2015 sampai 2018 dan didapat melalui teknik pengambilan purposive sampling sebanyak 12 perusahaan. Teknik analisis yang digunakan dalam penelitian ini adalah metode regresi linear berganda.
Hasil penelitian ini menunjukkan bahwa gender diversity dan etnis Tionghoa pada komposisi dewan komisaris dan dewan direksi tidak berpengaruh terhadap kinerja keuangan, age diversity pada komposisi dewan komisaris berpengaruh positif terhadap kinerja keuangan, age diversity pada komposisi dewan direksi berpengaruh negatif terhadap kinerja keuangan, tenure diversity pada komposisi dewan komisaris berpengaruh negatif terhadap kinerja keuangan, dan tenure diversity pada komposisi dewan direksi tidak berpengaruh terhadap kinerja keuangan.
PENGARUH CAR, DPK, DAN BOPO TERHADAP LDR PADA BANK UMUM DI INDONESIA PERIODE 2014 - 2018
Authors: Kotijah Kotijah , Guspul Ahmad 
Published: March 2022

Penelitian yang dilakukan pada saat ini untuk membuktikan pengaruh Capital Adequacy Ratio (CAR), Dana Pihak Ketiga (DPK) dan Biaya Operasional Pendapatan Operasional (BOPO) terhadap Loan to Deposit Ratio (LDR) pada bank umum yang tergolong kedalam buku 4 atau memiliki modal lebih dari Rp. 30 Triliun selama perioe 2014 – 2018.
Dengan model sampel jenuh / sensus. Data yang digunakan adalah dari 7 bank termasuk buku 4 dan periode penelitian yakni 5 tahun berturut - turut.
Hasil penelitian ini menunjukkan bahwa CAR tidak berpengaruh terhadap LDR (H1 ditolak), DPK tidak berpengaruh terhadap LDR (H2 ditolak), BOPO berpengaruh positif terhadap LDR (H3 diterima)
PENGARUH KAPASITAS INDIVIDU, ASIMETRI INFORMASI, DAN PENEKANAN ANGGARAN PADA BUDGETARY SLACK DENGAN BUDAYA ORGANISASI SEBAGAI PEMODERASI
Authors: Rosmilasari Sausi , Hartiyah Sri 
Published: March 2022

Penelitian ini bertujuan untuk mengetahui faktor-faktor yang memepengaruhi senjangan anggaran pada SKPD Kabupaten Banjarnegara. Penelitian ini merupakan penelitian kuantitatif. Populasi penelitian ini adalah seluruh karyawan pada 12 SKPD Kabupaten Banjarnegara jumlah sampel yang diperoleh yaitu 62 responden, sedangakan teknik pengambilan sempel menggunakan teknik purposive sampling. Teknik pengumpulan data menggunakan kuesioner. alat analisis yang digunakan adalah regresi linier berganda dan moderate regression analysis (MRA). Dari hasil penelitian dapat disampaikan bahwa diketahui bahwa kapasitas indiviu, asimetri informasi dan penekanan anggaran berpengaruh terhadap senjangan anggaran pada SKPD Kabupaten Banjarnegara, budaya organisasi mampu memoderasi pengaruh kapasitas individu pada senjangan anggaran, sedangkan pada pengaruh asimetri informasi dan penekanan anggaran pada senjangan anggaran budaya organisasi tidak memoderasi. Hasil uji Adjusted R Square pada peneitian ini diperoleh sebesar 0,556 atau 55,6% artinya bahwa 55,6% senjangan anggaran dipengaruhi oleh kapasitas individu, asimetri informasi dan penekanan anggaran pada SKPD Kabupaten Banjarnegara. Sedangkan sisanya 44,4% dipengaruhi oleh variabel lain diluar dari penelitian ini.
BYSTANDER EFFECT, WHISTLEBLOWING SYSTEM, INTERNAL LOCUS OF CONTROL DAN KOMPETENSI APARATUR DALAM PENCEGAHAN FRAUD DANA DESA
Authors: Wakhidah Anisa Kiromil , Mutmainah Kurniawati 
Published: March 2022

Penelitian ini bertujuan untuk menguji pengaruh bystander effect, whistleblowing system, internal locus of control, dan kompetensi aparatur terhadap pencegahan fraud dalam pengelolaan dana desa. Populasi dalam penelitian ini adalah semua perangkat desa di Kecamatan Kemiri Kabupaten Purworejo. Teknik pengambilan sampel dalam penelitian ini dilakukan dengan menggunakan metode purposive sampling. Sampel dalam penelitian ini adalah aparatur di 40 desa di Kecamatan Kemiri Kabupaten Purworejo. Responden yang dipilih menjadi sampel dalam penelitian ini adalah kepala desa dan bendahara desa sehingga diperoleh jumlah sampel dalam penelitian ini adalah 80 responden. Data dikumpulkan melalui kuesioner dan metode analisis yang digunakan dalam penelitian ini adalah regresi linear berganda dengan bantuan perangkat lunak SPSS Statistics v.23.Hasil penelitian ini menunjukkan bahwa bystander effect berpengaruh negatif terhadap pencegahan fraud dana desa, sedangkan whistleblowing system, internal locus of control dan kompetensi aparatur berpengaruh positif terhadap pencegahan fraud dalam pengelolaan dana desa
Optimization Possibilities in Final Products Inventory Services
Authors: Juhász János 
Published: March 2022

My study is focusing on the internal companies’ logistics services to increase the efficiencies of final products inventory. Competitiveness and effectiveness are important factors in the manufacturing and services processes, where are needed to serve out the whole logistics networks for different sectors. My article provides an integrated overview of the fictitious company' final products inventory activities and its intensification. There are three related area of the inventory activities: packaging, forms of final products load and the related vehicle unit services. This paper shows alternative solutions to improve the sensitivity of the final products processes. The methodology enables to find the right resource allocations for the efficient operation in the service of inventory operation.
Mitral Regurgitation and Body Mass Index Increase the Predictability of Perioperative Bleeding in Anticoagulated Patients With Nonvalvular Atrial Fibrillation
Authors: Huang Hao , Cai Chi , Hua Wei , Zhang Nixiao , Niu Hongxia , Chen Xuhua , Wang Jing , Jia Yuhe , Chu Jianmin , Tang Min , Zhang Shu 
Published: March 2022

BackgroundCatheter ablation (CA) effectively restores sinus rhythm in atrial fibrillation (AF) but causes a short-term fluctuation in the coagulation state. Potential risk factors and better management during this perioperative period remain understudied.MethodsWe consecutively included 940 patients with nonvalvular AF who received CA at Fuwai Hospital, Beijing, China. Patients were divided into two groups according to their bleeding status during 3 months' anticoagulation. Any adverse events related to bleeding in the 3 months were evaluated. The HAS-BLED score and ABC-bleeding score, as well as other potential factors, were explored to predict bleeding risk.ResultsIn this observational study, 8.0% and 0.9% of the whole population suffered from bleeding and thromboembolic events, respectively. After adjusting for known factors related to bleeding, mitral regurgitation (MR, p for trend &lt;0.001) and body mass index (BMI, odds ratio (OR) = 0.920, 95% CI 0.852–0.993, p = 0.033) were the most significant ones. C-indexes of the HAS-BLED score and ABC-bleeding score for bleeding were 0.558 (0.492–0.624) and 0.585 (0.515–0.655), respectively. The incorporation of MR and BMI significantly improved the predictive value based on HAS-BLED score (C-index = 0.650, 95% CI 0.585–0.715, p = 0.004) and ABC-bleeding score (C-index = 0.671, 95% CI 0.611–0.731, p &lt; 0.001). The relative risk of mild-moderate MR was 4.500 (95% CI 1.625–12.460) in patients with AF having HAS-BLED = 1 and 4.654 (95% CI 1.496–14.475) in HAS-BLED ≥ 2, while it was not observed in patients with HAS-BLED = 0 (p = 0.722).ConclusionMore severe MR and lower BMI are associated with a higher incidence of perioperative bleeding, which helps improve the predictability of increased individual bleeding risk of a patient with nonvalvular AF who has received CA therapy and oral anticoagulants.
Serum Bilirubin Level Is Increased in Metabolically Healthy Obesity
Authors: Fu Jing , Wang Qiu , Zhang Lin , Liu Jia , Wang Guang 
Published: March 2022

ObjectivesBilirubin is a biochemical substance with metabolic benefits. The objective of this research was to elucidate the association between serum bilirubin levels and metabolic alterations in different obesity phenotypes.MethodsIn total, 1,042 drug-naive participants were included in the study. Of them, 541 were obese patients and 501 were age-matched and sex-matched healthy control subjects. The obese patients were divided into metabolically healthy obesity (MHO) group and metabolically unhealthy obesity (MUHO) group according to the levels of fasting plasma glucose (FBG), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and blood pressure (BP). Clinical and biochemical parameters including total bilirubin (TBil), indirect bilirubin (IBil) and direct bilirubin (DBil) were measured. ANOVA or Kruskal-Wallis H test was used to test differences among the three groups. Pearson and Spearman correlations were used to analyze the relationships between two parameters. The relationships between bilirubin and other variables were analyzed using Multivariate regression analysis.ResultsMHO group had favorable blood pressure, glucose and lipids profiles, along with increased TBil and DBil, and decreased high-sensitivity C-reactive protein (hsCRP) and homeostasis model assessment of insulin resistance (HOMA-IR) levels when compared to MUHO group (P &lt; 0.05 for all). TBil and DBil were negatively correlated with total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), fasting insulin (FINS), hsCRP and HOMA-IR, even after adjusted for age, gender and BMI (all P &lt;0.01). Multivariate regression analysis demonstrated that HOMA-IR was independently correlated with TBil and DBIi levels (β = -0.400, P &lt; 0.01).ConclusionMHO group harbors increased bilirubin level compared with MUHO group. HOMA-IR was independently correlated with TBil and DBIi levels.
Schisandrin B Induced ROS-Mediated Autophagy and Th1/Th2 Imbalance via Selenoproteins in Hepa1-6 Cells
Authors: Tan Siran , Zheng Zhi , Liu Tianqi , Yao Xiaoyun , Yu Miao , Ji Yubin 
Published: March 2022

Schisandrin B (Sch B) is well-known for its antitumor effect; however, its underlying mechanism remains confusing. Our study aimed to investigate the role of selenoproteins in Sch B-induced autophagy and Th1/Th2 imbalance in Hepa1-6 cells. Hepa1-6 cells were chosen to explore the antitumor mechanism and were treated with 0, 25, 50, and 100 μM of Sch B for 24 h, respectively. We detected the inhibition rate of proliferation, transmission electron microscopy (TEM), monodansylcadaverine (MDC) staining, reactive oxygen species (ROS) level and oxidative stress-related indicators, autophagy-related genes, related Th1/Th2 cytokines, and selenoprotein mRNA expression. Moreover, the heat map, principal component analysis (PCA), and correlation analysis were used for further bioinformatics analysis. The results revealed that Sch B exhibited well-inhibited effects on Hepa1-6 cells. Subsequently, under Sch B treatment, typical autophagy characteristics were increasingly apparent, and the level of punctate MDC staining enhanced and regulated the autophagy-related genes. Overall, Sch B induced autophagy in Hepa1-6 cells. In addition, Sch B-promoted ROS accumulation eventually triggered autophagy initiation. Results of Th1 and Th2 cytokine mRNA expression indicated that Th1/Th2 immune imbalance was observed by Sch B treatment in Hepa1-6 cells. Intriguingly, Sch B downregulated the majority of selenoprotein expression. Also, the heat map results observed significant variation of autophagy-related genes, related Th1/Th2 cytokines, and selenoprotein expression in response to Sch B treatment. PCA outcome suggested the key role of Txnrd1, Txnrd3, Selp, GPX2, Dio3, and Selr with its potential interactions in ROS-mediated autophagy and Th1/Th2 imbalance of Hepa1-6 cells. In conclusion, Sch B induced ROS-mediated autophagy and Th1/Th2 imbalance in Hepa1-6 cells. More importantly, the majority of selenoproteins were intimately involved in the process of autophagy and Th1/Th2 imbalance, Txnrd3, Selp, GPX2, Dio3, and Selr had considerable impacts on the process.
Increased HBV Coinfection and Decreased IFN-γ-Producing HBV-Specific CD8+ T Cell Numbers During HIV Disease Progression
Authors: Zhu Zhiqiang , Qin Yuanyuan , Liang Qi , Xia Wei , Zhang Tong , Wang Wen , Zhang Mengmeng , Jiang Taiyi , Wu Hao , Tian Ye 
Published: March 2022

ObjectiveTo investigate the characteristics and mechanism of the dynamics of HBV infection with the progression of HIV disease and to explore the different responses of T lymphocytes to HBV in HIV patients in different stages of disease.MethodsWe compared the rates and characteristics of HBV coinfection between 372 early HIV-infected and 306 chronically HIV-infected men who have sex with men (MSM) in the Beijing Youan Hospital from October 2006 to November 2014. We further analysed IFN-γ-producing HBV-specific CD8+ T cells in 15 early HIV-infected individuals and 20 chronic HIV-infected individuals with HBV coinfection.ResultsTwenty-three HBsAg-positive cases were detected among the 372 early HIV-infected patients of this cohort, and the coinfection rate was 6.18%, while 35 HBsAg-positive cases were detected among the 306 chronically HIV-infected patients, with a coinfection rate of 11.44%. The coinfection rate of the chronically HIV-infected patients was significantly higher than that of the early-infected patients (p=0.0005). The median CD4+ T cell count in the early HIV infection patients was 445 cells/μL (196-1,030 cells/μL), which was higher than that in the chronic HIV infection patients [358 cells/μL (17-783 cells/μL)] (p&lt;0.001). The proportion of IFN-γ-producing CD8+ T cells in early HIV-infected patients was significantly higher than that in chronically HIV-infected patients.ConclusionThe coinfection rate of HBV in HIV patients increases with HIV disease progression, which might be related to the decreased IFN-γ-producing HBV-specific CD8+ T cell numbers. The closely monitored HBV serum markers from the early stage of HIV infection are warranted.
Facilitators and Barriers to Dementia Assessment and Diagnosis: Perspectives From Dementia Experts Within a Global Health Context
Authors: Bernstein Sideman Alissa , Al-Rousan Tala , Tsoy Elena , Piña Escudero Stefanie D. , Pintado-Caipa Maritza , Kanjanapong Suchanan , Mbakile-Mahlanza Lingani , Okada de Oliveira Maira , De la Cruz-Puebla Myriam , Zygouris Stelios , Ashour Mohamed Aya , Ibrahim Hany , Goode Collette A. , Miller Bruce L. , Valcour Victor , Possin Katherine L. 
Published: March 2022

ObjectivesDementia poses one of the greatest global health challenges, affecting 50 million people worldwide. With 10 million new cases each year, dementia is a growing burden, particularly in low- and middle-income countries (LMIC). This study aimed to identify the facilitators and barriers to providing quality dementia assessment and care in LMICs from a global health perspective.Methods/DesignA qualitative semi-structured interview study with 20 dementia expert healthcare providers from 19 countries. To be included, providers had to: practice dementia assessment or care in LMICs where the population over age 60 is projected to more than double by 2050 and be recognized as a leading dementia expert in the region based on position, research publications, and/or policy leadership. Interviews were analyzed by a multidisciplinary team of researchers using thematic analysis.ResultsBarriers to dementia assessment and care included stigma about dementia, poor patient engagement in and access to healthcare, inadequate linguistic and cultural validation, limited dementia capable workforce, competing healthcare system priorities, and insufficient health financing. Facilitators included the rise in dementia awareness campaigns, dementia training for general practitioners, availability of family support and family caregivers, and national and international collaborations including coordinated policy efforts and involvement in international research initiatives.ConclusionsFindings from this study provide insights for prioritizing dementia assessment and care capacity-building in LMICs as a global health priority and for tailored public health approaches to strengthen dementia assessment and care at the individual, community, national, and multi-national levels.
Breathing Abnormalities During Sleep and Wakefulness in Rett Syndrome: Clinical Relevance and Paradoxical Relationship With Circulating Pro-oxidant Markers
Authors: Leoncini Silvia , Signorini Cinzia , Boasiako Lidia , Scandurra Valeria , Hayek Joussef , Ciccoli Lucia , Rossi Marcello , Canitano Roberto , De Felice Claudio 
Published: March 2022

BackgroundBreathing abnormalities are common in Rett syndrome (RTT), a pervasive neurodevelopmental disorder almost exclusively affecting females. RTT is linked to mutations in the methyl-CpG-binding protein 2 (MeCP2) gene. Our aim was to assess the clinical relevance of apneas during sleep-wakefulness cycle in a population with RTT and the possible impact of apneas on circulating oxidative stress markers.MethodsFemale patients with a clinical diagnosis of typical RTT (n = 66), MECP2 gene mutation, and apneas were enrolled (mean age: 12.5 years). Baseline clinical severity, arterial blood gas analysis, and red blood cell count were assessed. Breathing was monitored during the wakefulness and sleep states (average recording time: 13 ± 0.5 h) with a portable polygraphic screening device. According to prevalence of breath holdings, the population was categorized into the wakefulness apnea (WA) and sleep apnea (SA) groups, and apnea-hypopnea index (AHI) was calculated. The impact of respiratory events on oxidative stress was assessed by plasma and intra-erythrocyte non-protein-bound iron (P-NPBI and IE-NPBI, respectively), and plasma F2-isoprostane (F2-IsoP) assays.ResultsSignificant prevalence of obstructive apneas with values of AHI &gt; 15 was present in 69.7% of the population with RTT. The group with SA showed significantly increased AHI values &gt; 15 (p = 0.0032), total breath holding episodes (p = 0.007), and average SpO2 (p = 0.0001) as well as lower nadir SpO2 (p = 0.0004) compared with the patients with WAs. The subgroups of patients with WA and SA showed no significant differences in arterial blood gas analysis variables (p &gt; 0.089). Decreased mean cell hemoglobin (MCH) (p = 0.038) was observed in the group with WAs. P-NPBI levels were significantly higher in the group with WA than in that with SAs (p = 0.0001). Stepwise multiple linear regression models showed WA being related to nadir SpO2, average SpO2, and P-NPBI (adjusted R2 = 0.613, multiple correlation coefficient = 0.795 p &lt; 0.0001), and P-NPBI being related to average SpO2, blood PaCO2, red blood cell mean corpuscular volume (MCV), age, and topiramate treatment (adjusted R2 = 0.551, multiple correlation coefficient = 0.765, p &lt; 0.0001).ConclusionOur findings indicate that the impact of apneas in RTT is uneven according to the sleep-wakefulness cycle, and that plasma redox active iron represents a potential novel therapeutic target.
Eye Position Shifts Body Sway Under Foot Dominance Bias in the Absence of Visual Feedback
Authors: Tamaru Yoshiki , Matsugi Akiyoshi 
Published: March 2022

PurposeThe purpose of this study was to investigate whether information on extraocular muscle proprioception without visual information affects postural control.MethodsThirty-five healthy young volunteers participated in the study. Postural control outcomes included the center of pressure (CoP) for static standing, the total length of the sway of the CoP (LNG), and the sway area (SA), as well as the mean CoP in the mediolateral and anteroposterior directions. The following five eye-fixing positions were used: eye-up (E-Up), eye-down (E-Down), eye-right (E-Right), eye-left (E-Left), and eye-center (Center eye position). One-way ANOVA and Bonferroni correction was performed for statistical processing. Electrooculograms were recorded to detect eye orientation errors, measured with the eyes closed.ResultsThe results of this study showed no significant difference between the LNG and SA results when comparing respective eye positions (E-up, E-down, E-right, E-left) relative to E-Center (control). However, the average CoP was shifted to the right at E-Up, E-Down, and E-Left.ConclusionThese findings indicate that postural control may be affected by eye-body coordination depending on the position of the eyes, even without visual information.