bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of prolactin receptor blockade in a murine endometriosis interna model
Authors: Otto Christiane , Ulbrich Hannes‐Friedrich , Freiberg Christoph 
Published: January 2022

AbstractEndometriosis in an estrogen‐dependent disease that is characterized by the presence of endometrial tissue outside the uterine cavity leading to pain and infertility in many affected women. Highly efficient treatment options which create a hypo‐estrogenic environment can cause side effects such as hot flushes and bone mass loss that are not favorable for premenopausal women. Previous work has demonstrated that increased local or systemic prolactin seems to be involved in the pathogenesis of endometriosis. Here we examined two prolactin receptor (PRLR) blocking antibodies in a murine endometriosis interna model which relies on the induction of systemic hyperprolactinemia in female SHN mice. The severity of the disease is determined by the degree of endometrial invasion into the myometrium. In this model, endometriosis was inhibited by clinical gold standards such as progestins and anti‐estrogenic approaches. PRLR blockade completely inhibited endometriosis in this mouse model to the same extent as the anti‐estrogen faslodex or the GnRH antagonist cetrorelix. In contrast to cetrorelix and faslodex, the PRLR antibodies did not decrease relative uterine weights and were thus devoid of anti‐estrogenic effects. We therefore hypothesize that PRLR antibodies may present a novel and highly efficient treatment option for endometriosis with a good safety and tolerability profile. Clinical studies are on the way to test this hypothesis.
Costunolide protects against alcohol‐induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro
Authors: Mao Jingxin , Zhan Honghong , Meng Fancheng , Wang Guowei , Huang Dan , Liao Zhihua , Chen Min 
Published: January 2022

AbstractCostunolide (cos) derived from the roots of Dolomiaea souliei (Franch.), which belongs to the Dolomiaea genus in the family Compositae, exert the anti‐inebriation effect mainly by inhibiting the absorption of alcohol in the gastrointestinal tract. However, the protective effect of cos against alcohol‐induced liver injury (ALI) remains obscure. The present study was aimed to evaluate the hepatoprotective effects of cos (silymarin was used as positive control) against ALI and its potential mechanisms. MTT was used to examine the effect of cos on the cell viability of L‐02 cells. Plasma was separated from blood that used to test the levels of TNF‐α, IL‐6 and IL‐12, and LPS while serum separated from blood which used to detect the level of ALT and AST. Liver tissues were obtained for histopathological examination and western blot analysis. Fresh mice feces samples were collected for the detection of bacterial composition. Cos exhibited protective effect against alcoholic‐induced liver injury by regulating gut microbiota capacities (higher relative abundance of Firmicutes and Actinobacteria while lower in Bacteroidetes and Proteobacteria), adjusting oxidative stress (reduced the activities of MDA and ROS while promoted SOD, GSH and GSH‐PX in L‐02 cells) and attenuating inflammation (decreased the levels of ALT, AST, LPS, IL‐6, IL‐12 and TNF‐α) via LPS‐TLR4‐NF‐κB p65 signaling pathway, which might be an active therapeutic agent for treatment of ALI.
The comparative effects of sacubitril/valsartan versus enalapril on pulmonary hypertension due to heart failure with a reduced ejection fraction
Authors: Zhao Ying , Tian Li‐guo , Zhang Li‐xin , Ma Tao , Di Liang , Wang Yan‐bo , Gu Xin‐shun , Wang Dan‐dan , Gao Shang , Wang Haiyan 
Published: January 2022

AbstractThe purpose of this study was to investigate the effects of sacubitril/valsartan on right ventricular (RV) function in patients with pulmonary hypertension (PH) due to heart failure with reduced ejection fraction (HFrEF). We prospectively enrolled patients with HFrEF‐induced PH admitted to the Department of Cardiology between August 2018 and December 2019. Patients were randomized to receive oral treatment with sacubitril/valsartan or enalapril. Epidemiological data were recorded before treatment. Echocardiography was performed at admission and 6 months of follow‐up, and all parameters were compared. Major adverse cardiac events (MACEs) were compared between baseline and 6 months follow‐up. There were no significant differences in the baseline characteristics between the two groups. After 6 months of treatment, both treatment groups improved the following parameters from baseline (mean ± SD): left atrium, left ventricle, the left ventricular ejection function (LVEF), RV systolic function (the tricuspid annular plane systolic excursion [TAPSE], the systolic pulmonary artery pressure [sPAP], and TAPSE/sPAP). After 6 months, sacubitril/valsartan improved significantly the following parameters compared with enalapril (all p < 0.05): LVEF (47.07 ± 6.93% vs. 43.47 ± 7.95%); TAPSE (15.33 ± 1.31 vs. 14.78 ± 1.36 mm); sPAP (36.76 ± 14.32 vs. 42.26 ± 12.07 mmHg); and TAPSE/sPAP ratio (0.50 ± 0.23 vs. 0.39 ± 0.14), respectively. There was no difference in readmissions due to recurrent heart failure. Sacubitril/valsartan seems to provide more beneficial effects among patients with HFrEF‐induced PH to improve RV function, along with a decrease in pulmonary pressure.
Quantitative feedback control of health care demand via non‐pharmaceutical interventions during an epidemic
Authors: Boje Edward 
Published: January 2022

AbstractOnce an infectious disease has become an epidemic and can no longer be contained, non‐pharmaceutical public health interventions may be used to reduce infection rates so as to control demand on health care resources including staff and hospital facilities. Feedback control is shown to have limited possibilities due to (often unmodeled) non‐minimum phase lag; uncertainty in model parameters and measurements; and the discrete time nature of practical controller implementation for the interventions. Classical susceptible‐exposed‐infected models do not capture real time delays in disease progression, or phase lag effects of discrete time feedback control. Non‐minimum phase lag constraints are more severe if the number of hospitalized individuals rather than the number of infected individuals is used as the measurement variable.
Reducing Contact Time of Droplets Impacting Superheated Hydrophobic Surfaces
Authors: Huang Chung‐Te , Lo Ching‐Wen , Lu Ming‐Chang 
Published: January 2022

AbstractReducing the contact time (tc) of a droplet impacting a solid surface is crucial in various fields. Superhydrophobic (SHB) surfaces are used to reduce tc at room temperature. However, at high temperatures, SHB surfaces cannot achieve tc reduction because of the failure of the coating materials or the Leidenfrost (LF) effect. Therefore, a surface that can suppress the LF effect and reduce tc at high temperatures is required. To create such a surface, a double‐reentrant groove (DRG) array surface with an overhanging structure on top of the microgrooves is developed. The overhanging structure renders the surface hydrophobic (HB). Despite its HB nature, the DRG surface's LF point (LFP) is observed at ≈530 °C, which is higher than the LFP on other HB surfaces. Moreover, a tc smaller than the inertia–capillary limit on the DRG surface is observed at between 400 and 500 °C. Accordingly, the DRG surface is currently the only HB surface for tc reduction at high temperatures. The DRG surface avoids the limitation of low LFPs observed on HB surfaces. Due to its HB properties, the DRG surface is determined to exhibit self‐cleaning characteristics and can be used in various applications at high temperatures.
Einsatz von Zwillingsträgerhilfsbrücken im Zuge einer Notmaßnahme zur Querung der BAB 40
Authors: Kosky Tobias , Zillinger Wulf , Shahnazian Ali , Ay Yasemin , Stranghöner Natalie , Afzali Nariman , Makevičius Lukas , Ungermann Dieter , Kalameya Jens 
Published: January 2022

AbstractAm 17. September 2020 ist ein Tanklaster auf der Autobahn A 40 zwischen Duisburg und Mülheim unterhalb von Eisenbahnüberführungen der DB AG vollständig ausgebrannt. Ein Teil der fünf Brückentragwerke wurde durch die extreme Temperaturentwicklung derart stark beschädigt, dass die Trag‐ und Verkehrssicherheit nicht mehr bestand und in Folge die betroffenen Strecken der DB AG gesperrt werden mussten. Durch die sofort begonnene technische Bearbeitung der Ersatzneubauten und die schnellen bahninternen und behördlichen Genehmigungen konnten der Neubau der Widerlager und des Mittelpfeilers, die Montage der Hilfsbrücken und die Errichtung des Gleiskörpers innerhalb kürzester Zeit durchgeführt werden. Die Wiederinbetriebnahme der gesperrten Strecken erfolgte bereits am 28. Dezember 2020 (Bauwerk 3) und am 6. September 2021 (Bauwerke 2, 4). Nur durch die Verwendung von Zwillingsträgerhilfsbrücken des Typs ZH26 aus dem Bestand der DB AG konnte der kurzfristige Ersatz der havarierten Brücken realisiert werden. Die gesamte Baumaßnahme wird nachfolgend beschrieben. Es werden die Hilfsbrückensysteme der DB AG und ihre Anwendungsgrenzen vorgestellt. Die Verlegung von zwei hintereinanderliegenden Hilfsbrücken als Hilfsbrückenkette und die Verwendung als Dauerbehelf bedingen bahninterne Genehmigungsverfahren. Die dazu erforderlichen Nachweise und die zum Nachweis der Ermüdungssicherheit erforderliche gutachterliche Stellungnahme zur Dauerhaftigkeit der Schraubenverbindungen werden beschrieben.
Precise modification of poly(aryl ether ketone sulfone) proton exchange membranes with positively charged bismuth oxide clusters for high proton conduction performance
Authors: Yin Yi‐Zhuo , Zhang Zhen‐Guo , He Wen‐Wen , Xu Jing‐Mei , Jiang Feng‐Yu , Han Xu , Di Wan‐Ting , Wang Zhe , Ma Shengqian 
Published: January 2022

AbstractIn the field of proton exchange membranes (PEMs), it is still a great challenge to explore new Nafion alternatives, maintaining the high proton conductivity and lowering the cost of practical application. In this work, a series of low sulfonated poly(aryl ether ketone sulfone) (SPAEKS) membranes hybridized by [Bi6O5(OH)3]2(NO3)10·6H2O (H6Bi12O16) have been successfully fabricated. When the doping amount of H6Bi12O16 reaches 5 wt%, the DS15‐Bi12‐5 showing the best proton conductive ability and mechanical properties. The proton conductivity can achieve 72.8 mS·cm−1 at 80°C and the tensile strength can reach 43.57 MPa. Confirmed by experimental data and activation energy (Ea) calculations, the existence of Bi cluster makes more hydrogen bonds, providing additional proton hopping sites and offers more proton transport vehicles, leading to a high proton conduction performance. This work proved that polyoxometalates (POMs) can replace the role of sulfonate groups in SPAEKS to a certain extent and work out the defects of high sulfonation, making a remarkable contribution to the practical application of low sulfonated SPAEKS.
Anticancer potential of corilagin on T24 and TSGH 8301 bladder cancer cells via the activation of apoptosis by the suppression of NF‐κB‐induced P13K/Akt signaling pathway
Authors: Yu Xiaodong , Wu Tao , Liao Bo , Du Zhongbo , Zhu Pingyu 
Published: January 2022

AbstractBladder cancer (BC) is a primary source of malignancy‐associated death, and the mortality rate is high due to its prevalence of metastasis. Corilagin (CLG), a bioactive constituent of numerous medicinal plants, exerts assorted pharmacological actions comprising anti‐cancer, apoptotic, anti‐inflammatory, and hepatoprotective. CLG possesses a substantial anti‐tumor prospective and less noxiousness in normal cells in vitro. However, the molecular mechanisms of CLG on BC cells are not studied well. The current research explored the molecular process intricate in the anticancer and anti‐proliferative actions of CLG on the relocation of BC cells T24 and TSGH 8301. The cytotoxicity, apoptosis, adhesion, and migration of CLG on BC cells T24 and TSGH 8301 were evaluated by MTT assay, DAPI, Rh‐123, cell adhesion, and cell migration assay. The results point out that CLG inhibits the viability, adhesion, movement, incursion, and inflammation, whereas persuades BC cells apoptosis in a concentration‐dependent mode. Besides, CLG treated with T24 and TSGH‐8301 cells subdue inflammatory and PI3K/Akt signaling pathways. CLG is accomplished of impeding BC cell migration, invasion, and metastasis through the repression of the NF‐κB mediated P13K/Akt signaling. Our findings offer a unique vision into the demonstration of the anti‐cancer potential of CLG on BC cells.
Exploring the geometry of supersymmetric double field theory
Authors: Butter Daniel 
Published: January 2022

Abstract
The geometry of $$ \mathcal{N} $$
N
= 1 supersymmetric double field theory is revisited in superspace. In order to maintain the constraints on the torsion tensor, the local tangent space group of O(D) × O(D) must be expanded to include a tower of higher dimension generators. These include a generator in the irreducible hook representation of the Lorentz group, which gauges the shift symmetry (or ambiguity) of the spin connection. This gauging is possible even in the purely bosonic theory, where it leads to a Lorentz curvature whose only non-vanishing pieces are the physical ones: the generalized Einstein tensor and the generalized scalar curvature. A relation to the super-Maxwell∞ algebra is proposed. The superspace Bianchi identities are solved up through dimension two, and the component supersymmetry transformations and equations of motion are explicitly (re)derived.
Breakdown of hydrodynamics from holographic pole collision
Authors: Liu Yan , Wu Xin-Meng 
Published: January 2022

Abstract
We study the breakdown of diffusive hydrodynamics in holographic systems dual to neutral dilatonic black holes with extremal near horizon geometries conformal to AdS2 × R2. We find that at low temperatures by tuning the effective gauge coupling constant in the infra-red, the lowest non-hydrodynamic mode, which collides with the charge diffusive mode and sets the scales at which diffusive hydrodynamics breaks down, could be either an infra-red mode or a slow mode, resulting in different scaling behaviors of the local equilibrium scales. We confirm that the upper bound for the charge diffusion constant is always satisfied using the velocity and timescale of local equilibration from the pole collision. We also examine the breakdown of hydrodynamics at general temperature and find that the convergence radius has nontrivial dependence on temperature, in addition to the effective gauge coupling constant.
The growing threat of light pollution to ground-based observatories
Authors: Green Richard F. , Luginbuhl Christian B. , Wainscoat Richard J. , Duriscoe Dan 
Published: January 2022

AbstractHuman activity is rapidly increasing the negative impact of artificial skyglow at even the most remote professional observatory sites. Assessment of the actual impact requires an understanding of the propagation as a function of source spectral energy distribution. The higher blue content of light-emitting diodes being widely used as replacement for sodium discharge lamps has greater impact closer to the source, and less impact for more distant mountain-top sites. All-sky cameras with moderate angular resolution provide data and metrics sufficient to model and remove celestial contributions and provide measures of artificial light contribution. The natural skyglow is significantly affected by solar activity, which must be accounted for in determining secular trends in the artificial component. With the availability of the New World Atlas of the Artificial Sky Brightness, a direct comparison is made of the modeled artificial contribution to the sites with the largest aperture telescopes, noting the possible systematic errors in individual cases. Population growth of the nearest urban centers allows a prediction of the change in that brightness over a decade. All site protections are effected primarily by national or regional regulation. A collection of worldwide regulations shows that most are leveraged off environmental protection statutes, while in the U.S., they are largely based on land-use zones. Particular examples are presented in more detail for Flagstaff, Arizona, and the Island of Hawai’i. The latest rapidly growing threat is that of reflected sunlight from large constellations of satellites in low-earth orbit. A snapshot is provided of that rapidly changing situation. In all cases, astronomers must become very proactive in educating the public about the cultural value of visual or naked eye astronomy as well as the science and the need for access to a dark night sky for astronomical research.
Bilateral anterior compartment syndrome secondary to psychogenic polydipsia
Authors: Hughes William , McCormack Neill , Cattigan Claire , Thomas Damon , Goldie Stephen J. 
Published: January 2022

Abstract
Compartment syndrome is a surgical emergency requiring urgent release of the muscular compartments to prevent ischaemia and tissue death. Unusual presentation patterns or aetiological factors may be confusing, delaying the diagnosis and prompt management. We report a rare case of bilateral anterior compartment syndrome, secondary to psychogenic polydipsia. Compartment pressures were measured using a manometer. The patient was expedited to theatre for exploration. A literature review was performed to search for similar cases. In our case, a 42-year-old male presented confused and agitated with bilateral lower limb pain unresponsive to opiates. He had a past medical history of schizophrenia with psychogenic polydipsia, consuming 10 L of cola soft drink per day prior to presentation. Blood tests showed sodium of 112 mmol/L and a peak creatinine kinase of 13,417 U/L. On examination, he had tense and swollen bilateral anterior legs; posterior calves were soft. Left and right anterior compartment pressures were measured at 60 mmHg and 90 mmHg respectively (normal limit < 30 mmHg). At operation, bilateral fasciotomies of the anterior compartments were performed and bulging muscles were found. Reported cases similar to this resulted in permanent disability due to delays in recognising the diagnosis. Follow-up of this patient showed return of normal sensation and movement of the muscles of the anterior compartment. Hyponatraemia as a result of psychogenic polydipsia is well recognised, but isolated anterior compartment syndrome is a rare complication of hyponatraemia. This case report highlights the need to consider non-traumatic causes of compartment syndrome.Level of evidence: Level V, Diagnostic study
Spatial distribution of the protist community in the southern part of the Okhotsk Sea off Hokkaido during summer
Authors: Hamao Yusuke , Matsuno Kohei , Mitani Yoko , Yamaguchi Atsushi 
Published: January 2022

AbstractThe southern part of the Okhotsk Sea off Hokkaido has rich fishery resources supported by high primary production. The phytoplankton community has been described by several studies based on size-fractionated chlorophyllaconcentration and primary production; however, the details of the species composition of nano- and micro-protist communities have not been well investigated. We evaluated the spatial distribution and relationship with hydrography of nano- and micro-protist communities in the southern region of the Okhotsk Sea off Hokkaido during the summer of 2019. Forty-two species of diatoms from 19 genera, dinoflagellates from 7 genera, tintinnid ciliates, oligotrich ciliates, and 1 genus of silicoflagellates were identified. Their spatial distribution showed distinct differences among the taxa. Cluster analysis based on the protist cell density identified six groups with geographically well-distinguished distributions. Diatom-dominant communities were distributed in the Cold Water Belt and Soya warm current along the coastal area of Hokkaido. Nanoflagellate-dominated communities were distributed in the offshore area. Some harmful species of diatoms (Pseudonitzschia pseudodelicatissima) and dinoflagellates (Alexandriumspp.) were dominant in the Cold Water Belt off Wakkanai. We suggest that the upwelling of cold water could increase the abundance of harmful species, with immanent negative impacts on marine ecosystems or fishery resources. In summary, the species composition and abundance of the summer protist community was strongly related to different water masses in the southern part of the Okhotsk Sea off Hokkaido.
Abraham Model Descriptors for Melatonin; Prediction of Solution, Biological and Thermodynamic Properties
Authors: Liu Xiangli , Abraham Michael H. , Acree William E. 
Published: January 2022

AbstractLiterature solubilities have been used to obtain properties or descriptors of melatonin. These indicate the chemical nature of melatonin: it is dipolar and has moderate hydrogen bond acidity and hydrogen bond basicity. The descriptors can be combined with equations that we have previously constructed to estimate water–solvent partition coefficients and solubilities in a huge number of organic solvents. In the same way, a range of biological properties can be estimated. These include blood–tissue partitions, water–skin partition and permeability through skin.
Characterization, cytotoxicity, and genotoxicity properties of novel biomediated nanosized-silver by Egyptian Streptomyces roseolus for safe antimicrobial applications
Authors: Elnady Asmaa , Sorour Noha M. , Abbas Rateb N. 
Published: January 2022

AbstractMulti-drug resistant bacteria are not effectively managed with current treatments, making it a serious global problem. Therefore, there is an essential need for finding new antimicrobial agents. In this regard, silver nanoparticles (Ag-NPs) have been projected as a new generation of antimicrobial agents. Ag-NPs were biomediated by Egyptian Streptomyces roseolus for the first time, which was molecularly identified using 16S rRNA sequencing under accession no. MT071505. Biosynthesized Ag-NPs were characterized using UV–Vis spectroscopy, XRD, TEM, FTIR, and DLS. FTIR analysis confirmed the presence of different bioactive functional groups, such as N–H, C–H, C–O–C, C–NH2, and C=O acting as bioreducing/stabilizing agents for Ag-NPs. Ag-NPs exhibited antimicrobial activity against some multi-drug resistant Gram-positive and Gram-negative pathogens. MBC of Ag-NPs against Listeria monocytogenes and Klebsiella pneumonia were 0.195 and 0.048 mg/mL, respectively, with a tolerance level of 2 confirming its biocidal effect. SEM imaging of Ag-NPs-treated L. monocytogenes and K. pneumonia showed shrunk destroyed cells after 6 h of treatment. Biosynthesized Ag-NPs exhibited IC50 of < 0.3 and 8.21 mg/mL, on normal Human Skin Fibroblast, and Blood Lymphocytes, respectively. IC50 values were significantly higher than its MBC values, with no harmful cytotoxic effect, thus can be safely applied at its biocidal concentration. For biosafety purposes, the genotoxicity of biosynthesized Ag-NPs was assessed using Comet assay for the first time on Blood Lymphocytes, with zero-tail and 100% head intensity indicating non-genotoxic effect. An ecofriendly biomediated synthesis of Ag-NPs was described with easy scale-up, non-toxic by-products, so, it can be recommended as a powerful-safe antimicrobial agent.
Graphical abstract