bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occupational-Related Shoulder and Neck Pain Among the Working Population of Ethiopia: Systematic Review and Meta-Analysis
Authors: Mengistu Dechasa Adare , Dammu Yohannes Mulugeta , Debelu Desi , Muche Liku , Mulat Salie , Berhanu Ashenafi , Muzeyin Mohammed , Ahmed Fila 
Published: December 2022

Abstract
Background: Currently, work-related musculoskeletal disorders are a significant public health concern and are one of the leading causes of disability-adjusted life years and reduced quality of life. Therefore, the current study aimed to determine the country-wide prevalence of work-related musculoskeletal disorders, particularly shoulder and neck pain, in Ethiopia.Methods: This study considered studies conducted in Ethiopia, written in English and published in 2017-2020 and searched using electronic databases such as PubMed/MEDLINE, Web of Science, Google Scholar, CINAHL, SCOPUS, Embase, African Index Medicus, and African Journals Online database. The quality assessment of the studies was done using Joanna Briggs Institute Critical Assessment tools to determine the relevance of each included article to the study.Results: The study found that the pooled prevalence of shoulder and neck pain in the previous year represented 37.9% [95% CI:26.5, 50.8%] and 29.9% [95% CI: 20.1, 41.9], respectively. Based on the subgroup analysis, the pooled prevalence of shoulder pain in the last year based on the study population, publication year and study region was 47.6% [95% CI: 45.8, 49.4%], 49.8% [95% CI: 45.7, 53.9%] and 44.6% [95% CI: 41.4, 47.8%], respectively, while the pooled prevalence of neck pain in the last year based on the study population, publication year and study area was 39.1% (95% CI: 37.5, 40.7%], 25.1% [ 95% CI: 20.8, 29.9%] and 32.6% [95% CI: 29.8, 35.5%], respectively.Conclusions This study found that at least one third of the study participants had experienced occupational-related shoulder and/or neck pain in the previous year. The study suggests that there is a need to implement occupational health and safety measure to reduce work-related musculoskeletal disorders and other hazards.
How do we Sustain Multidimensional Poverty Escape? Employing the Zero poverty Tripods
Evidence from Rural Ethiopia
Authors: Haile Dereje , Tsehay Abrham Seyoum , Bekele Alemu Azmeraw , Gebremaryam Haymanot Asfaw 
Published: December 2022

Abstract
Ending extreme multidimensional poverty needs three-pronged approaches of sustained escapes, stopping impoverishment of the vulnerable non-poor, and tackling chronic poverty. Using the Ethiopian Socioeconomic Survey data (2011/12–2015/16), this study attempted to explore the major options for eradicating multidimensional poverty. Multidimensional poverty is estimated using Alkire and Foster methodology. The study finds a moderate decline in multidimensional poverty through the change in the headcount than the intensity of deprivation. The findings suggest that multidimensional poverty needs to be interrupted by investments in infrastructure to improve market access, commercialization, and human capital formation. Hence, urbanization and rural livelihood transition deserve much more attention when striving for sustainable poverty alleviation. Moreover, institutional measures that enhance rural transformation would go a long way in creating the conditions that enable sustained multidimensional poverty escape and breaking the vicious cycle of subsistence and vulnerability of smallholder farming. Policies requiring more attention to enhance sustained escape from poverty are access to productive assets, commercialization, saving, wage labor participation, and promoting the rural non-farm economy to get to poverty zero. The need to foster growth from below is also the most vital solutions of creating the conditions that enable poor households to escape and then stay out of poverty. Equally important, impoverishment of the vulnerable non-poor needs to be protected by enhancing social protection, in the form of ex-ante insurance and post-shock safety nets, that would have substantial returns, not just in terms of the short-run welfare gains, but also in ways to meet long-term objectives.
Exploring Mental Health Outcome Variables in Outdoor Adventure Education
Authors: Davidson Curt , Ewert Alan 
Published: December 2022

AbstractBackground: The COVID-19 Pandemic has changed many facets of outdoor recreation. These changes have significantly impacted various outdoor adventure and experiential education (OAEE) programs.Purpose: Using past literature, four variables were thought to represent future and important student outcome variables for which OAEE programs should consider striving to impact. Accordingly, the purpose of this pilot study was to examine the effects of participation in an OAEE program and the impacts of coping with anxiety and uncertainty, depression, hopelessness, and enhancing resilience.Approach: This study used an online data collection software with a 30-item inventory to measure selected variables. Using a retrospective-pre design, data were collected and analyzed using repeated measuret-tests.Results:This study showed significant differences on anxiety, hopelessness, and resilience.Implications: Results suggest that OAEE programs can effectively enhance an individual's ability to cope with anxiety and hopelessness while enhancing their levels of resilience.
Multi-Fractal Detrended Cross-Correlation Heatmaps for Time Series Analysis
Authors: Junior Paulo Roberto de Melo Barros , Bunge Kianny Lopes , Rodrigues Vitor Hugo Serravalle  Reis , Santiago Michell Thompson Ferreira , Marinho Euler Bentes dos Santos , Silva Jose Luis Lima de Jesus 
Published: December 2022

Abstract
Complex systems in biology, climatology, medicine, and economy hold emergent properties such as non-linearity, adaptation, and self-organization. These emergent attributes can derive from large-scale relationships, connections, and interactive behavior despite not being apparent from their isolated components. It is possible to better comprehend complex systems by analyzing cross-correlations between time series. However, the accumulation of non-linear processes induces multiscale structures, therefore, a spectrum of power-law exponents (the fractal dimension) and distinct cyclical patterns. We propose the Multifractal Detrended Cross-Correlation Heatmaps (MF-DCCHM), a systematic approach representing a process with clear, defined, and repeatable steps to map the relationships between fluctuations of signals on different time scales and regimes. Our dataset is composed of sales and inventory from the Brazilian automotive sector and macroeconomic descriptors, namely the Gross Domestic Product (GDP) per capita, Nominal Exchange Rate (NER), and the Nominal Interest Rate (NIR) from the Central Bank of Brazil. Our results indicate cross-correlated patterns that can be directly compared with the power-law spectra for multiple regimes. We have also identified cyclical patterns of high intensities that coincide with the Brazilian presidential elections. The MF-DCCHM uncovers non-explicit cyclic patterns, quantifies the relations of two non-stationary signals (noise effect removed), and has outstanding potential for mapping cross-regime patterns in multiple domains.
Direct Admission Versus Interhospital Transfer for revascularisation in non-ST-Segment Elevation Myocardial Infarction
Authors: Steenbergen GJ van , Demandt JPA. , Schulz DN , Tonino PA , Dekker L , Vermeer-Gerritzen Iris , Wijnbergen IF , Thijssen HJM , Theunissen LJHJ , Heijmen HPCM , Haest RJP , Vlaar PJ , Veghel D 
Published: December 2022

Abstract
Objective We aim to compare quality parameters, costs and clinical outcomes of NSTEMI patients stratified by centre of first presentation and revascularisation strategy.
Methods Hospital claim data on patients admitted with a NSTEMI between 2017 and 2019 from one of the largest health insurers in the Netherlands were used for this study. Included patients were stratified by revascularisation strategy (PCI, CABG or no revascularisation [noRevasc]) and subdivided by centre of presentation per treatment. The primary outcomes were the following quality measures: duration between admission and revascularisation, length of hospital stay and number of intracoronary procedures. Total costs (accumulation of costs for hospital claims and inter-hospital ambulance rides) and clinical outcomes at 30 days (MACE: all-cause mortality, recurrent myocardial infarction and cardiac readmission) were used as secondary outcomes.
Results A total of 9641 NSTEMI events (9167 unique patients) were analysed for which PCI was performed during admission in 4448 cases, CABG in 816 cases and no revascularisation was performed in 4377 cases. Direct presentation at an intervention centre occurred in 59%, 55% and 60% of cases, respectively. For PCI, direct presentation at an intervention centre yielded shorter time to revascularisation, shorter hospitalisation and less intracoronary procedures per patient. For CABG, time to revascularisation and hospitalisation were shorter. Total costs were significantly lower in case of direct presentation in an intervention centre for all treatment groups while MACE was similar.
Conclusion Direct admission of NSTEMI patients to an intervention centre might yield improvement potential for current NSTEMI care.
Polymorphism of FEN1 Gene is Associated with DNA Damage of Cytb Gene in Arsenic-Exposed Workers
Authors: Xu Jie , Zhao Ruihuan , Jiang Jinjun , Ma He , Liu Na , Jiang Chenglan , Li Shuting , He Yuefeng 
Published: December 2022

Abstract
Objective: To explore the relationship between Polymorphism of FEN1 Gene and DNA Damage of Cytb Gene in Arsenic-Exposed Workers.
Methods: The content of arsenide in urine of 79 arsenic-exposed workers and 24 agricultural workers was detected by an atomic absorption spectrophotometer. The DNA damage level of Cytb gene and the polymorphism of FEN1 gene in peripheral blood were detected by polymerase chain reaction.
Results: The increased exposure to arsenic caused DNA damage of Cytb gene, resulting in an increase in the content of arsenide in urine and hypomethylation of arsenic metabolism. Meanwhile, there was a potential positive correlation between the FEN1 rs174538 AA or GA+AA allele and the DNA damage level of Cytb gene.
Conclusions: The DNA damage of Cytb gene caused by arsenic exposure is related to FEN1 gene polymorphism, the content of arsenide in urine and the level of arsenic methylation metabolism.
Psoas abscess in pregnancy - a review of the literature and suggestion of minimally invasive treatment options
Authors: Schröder Carolin , Calite Elina , Böckenhoff Paul , Büttner Thomas , Stein Johannes , Gembruch Ulrich , Strizek Brigitte 
Published: December 2022

Abstract
Aim: Less than a dozen cases of psoas abscesses in pregnancy have been described in the literature. We reviewed the literature when treating a patient with a psoas abscess after ipsilateral double J-ureteral stent placement (in the following: “double J-stent”) due to infected hydronephrosis.
Methods: In January 2022, this review was searched using the Pubmed/MEDLINE database and the mesh terms “Psoas Abscess” AND “Pregnancy”. Studies were included in any language and of all years, describing a psoas abscess during pregnancy. When patients did not have a psoas abscess, the abscess occurred after pregnancy, or when there was no full text available, the article was excluded.
Main Results: Ten case reports about patients with psoas abscesses during pregnancy were included. The classical symptomatic triad of psoas muscle abscess included lower back pain, limping and persistent fever with daily spikes. However, in most cases, not all three symptoms can be found. Especially, fever is absent in more than half of the patients. Psoas abscesses are described between 13 and 39 weeks of gestation. Primary psoas abscesses with haematogenous spread are more common during pregnancy than secondary with spread per continuitatem. In the literature, the main reasons for psoas abscess are spinal tuberculosis, drug abuse or underlying diseases such as Crohn’s disease. It is not uncommon for the definite cause to be unclear.
Regarding the patient's symptoms, pyelonephritis is often considered a possible aetiology. In general, the main treatment options include antibiotic treatment and abscess drainage. There is no higher caesarean section rate, and no negative outcome for the fetus has been described.
Case presentation: In our patient, a 38-year-old obese Caucasian woman, who had received a left double J-stent for infected hydronephrosis at 15 weeks of gestation, we successfully treated a psoas abscess of 20 x 10 cm with a sonographically assisted abscess drainage and antibiotics. The further course of pregnancy and the elective repeat caesarean section at 38 + 0 weeks of gestation were without any problems. Double J-stent placement and laser stone lithotripsy during puerperium were performed because of recurrent urolithiasis.
Conclusions: Although rare, psoas abscesses can occur during pregnancy, and it has often been treated surgically in the past. A psoas abscess as a complication after infected hydronephrosis and intervention during pregnancy has never been reported in the literature. Even for obese patients, minimally invasive therapy may be a treatment option that has rarely been reported in the literature.
Effects of Native and Particulate Polyphenols on Dna Damage and Cell Viability After UV-C Exposure
Authors: Potapovich Alla I. , Kostyuk Tatyana V. , Ishutina Olga V. , Shutava Tatsiana G. , Kostyuk Vladimir A. 
Published: December 2022

Abstract
Background
plant polyphenols have poor water solubility, resulting in low bioavailability. In order to overcome this limitation, the drug molecules can be coated with multiple layers of polymeric materials.
Methods
microcrystals of quercetin and resveratrol coated with a (PAH/PSS)4 or (CH/DexS)4 shell were prepared using the layer-by-layer assembly method; cultured human HaCaT keratinocytes were treated with UV-C and after that cells were incubated with native and particulate polyphenols. DNA damage, cell viability and integrity, were evaluated by comet-assay, using PrestoBlueTM reagent and lactate dehydrogenase (LDH) leakage test.
Results
the data obtained indicate that: both native and particulate polyphenols added immediately after UV-C exposure increased cell viability in a dose-dependent manner, however the efficiency of particulate polyphenols was more pronounced; quercetin coated with a (PAH/PSS)4 or (CH/DexS)4 shell more effectively than the native compound reduced the number of single-strand DNA breaks in the nuclei of keratinocytes exposed to UV-C radiation; native and particulate resveratrol were ineffective against DNA damage.
Conclusion
quercetin reduces cell death caused by UV-C radiation and increase DNA repair capacity. Coating quercetin with (PAH/PSS)4 or (CH/DexS)4 markedly enhanced its impact on DNA repair probably by facilitating transport into the nucleus.
Comparative genetic and epigenetic of the Wedelia trilobata (L.) from different regions
Authors: Xiao Yusha , chen Xiuqing , Ying yuhan , Zheng jiening , Yi Huixian , Song Liying 
Published: December 2022

Abstract
Background
Wedelia trilobata (L.) Hitchc., is a common and widespread invasive plant in South China. In order to further explore the molecular mechanisms of its rapid adaptation, we selected DNA methylation-sensitive amplified polymorphism (MSAP) and simple sequence repeats (SSR) to analyze 60 W. trilobata individuals from Fuzhou (FZ), Haikou (HK), Jinghong (JH) and Guangzhou (GZ).
Results
In this study,The Shannon diversity index (I) of SSR and MSAP Nei are 0.236, 0.184; the average methylation rate of W. trilobata from the four regions is 18.25% − 32.92%, indicating that W. trilobata is highly methylated. In the unweighted pair group method with an arithmetic mean (UPGMA) phylogenetic tree, all populations in the MSAP are clustered together. The geographical distance between HK and JH is the closest, and GZ is the farthest from the other three populations. Epigenetic distance is more susceptible to geographical distance, as the correlation between epigenetic distance and geographical distance is significantly higher than that between genetic distance and geographical distance by Mantel analysis.
Conclusions
The result reveal that W. trilobata populations in different regions have high genetic and epigenetic diversity, as well as high methylation levels, in which epigenetic mechanisms play a stronger role.
RIPK3 Promotes Hantaviral Replication by Restricting JAK-STAT Signaling but not Triggering Necroptosis.
Authors: Ma Hongwei , Si Yue , Zhang Haijun , Zhou Ziqing , Zhu Xudong , Yang Yongheng , Liu He , Zhang Liang , Cheng Linfeng , Wang Kerong , Ye Wei , Lv Xin , Zhang Xijing , Hou Wugang , Zhao Gang , Lei Yingfeng , Zhang Fanglin 
Published: December 2022

Abstract
Hantaan virus (HTNV) is a rodent-borne virus that can cause hemorrhagic fever with renal syndrome (HFRS) with a case fatality rate of 15% and is listed as a re-emerging infectious disease (REID) in China. At present, no specific therapeutic strategies against HTNV are available. Interferon (IFN) is a crucial antiviral molecular which can trigger interferon-stimulated genes (ISGs) expression through the Janus kinase-signal transducer and activator of transcription 1 (JAK-STAT) pathway. Large quantities of IFN produced at the late stage of HTNV infection could not effectively restrain viral replication, the mechanism of which is still unclear. Here, we identified the receptor-interacting protein kinase 3 (RIPK3), a critical molecular to mediate necroptosis, could facilitate HTNV infection by blocking JAK/STAT signaling. HTNV infection promoted the total expression level of RIPK3, but not the phosphorylation of RIPK3, thus not leading to cell death. RIPK3 ablation could restrain HTNV replication by enhancing the expression of multiple ISGs, during which the type I IFN generation did not strengthened. Exogenously expressing RIPK3 might hinder the host anti-hantaviral responses. RIPK3−/− mice also maintained a robust ability to clear HTNV promptly with enhanced innate immune responses. Mechanistically, RIPK3 restricted STAT1 activation by bonding to STAT1 and blocking its phosphorylation sites, hence interfering with host IFN responses. Overall, these observations demonstrated a noncanonical function of RIPK3 during viral infection, and shed light on the novel evasion strategy of host innate immunity by HTNV.
VOCs species controlling O3 formation in ambient air and their sources in Kaifeng, China
Authors: Chen Yijia , Shi Yuqi , Ren Jie , You Guiying , Zheng Xudong , Liang Yue , Simayi Maimaiti , Hao Yufang , Xie Shaodong 
Published: December 2022

Abstract
The concentration of ozone has been in a rising crescendo in the last decade while the fine particles (PM2.5) is gradually decreasing but still at a high level in central China. Volatile organic compounds (VOCs) are the vital precursors of ozone and PM2.5. A total of 101 VOC species were measured in four seasons at five sites from 2019 to 2021 in Kaifeng. VOC sources and geographic origin of sources were identified by the positive matrix factorization (PMF) model and the HYbrid Single-Particle Lagrangian Integrated Trajectory transport model. The source-specific OH loss rates (LOH) and ozone formation potential (OFP) were calculated to estimate the effects of each VOC source. The average mixing ratios of total VOCs (TVOC) were 43.15 parts per billion (ppb), of which the alkanes, alkenes, aromatics, halocarbons, and oxygenated VOCs respectively accounted for 49%, 12%, 11%, 14%, and 14%. Although the mixing ratios of alkenes were comparatively low, they played a dominant role in the LOH and OFP, especially ethene (0.55 s− 1, 7%; 27.11 µg/m3, 10%) and 1,3-butadiene (0.74 s− 1, 10%; 12.52 µg/m3, 5%). The vehicle-related source which emitted considerable alkenes ranked as the foremost contributing factor (21%). Biomass burning was probably influenced by other cities in the western and southern Henan and other provinces, Shandong and Hebei.
Structured Channel Covariance Estimation from Limited Samples for Large Antenna Arrays
Authors: Yang Tianyu , Khalilsarai Mahdi Barzegar , Haghighatshoar Saeid , Caire Giuseppe 
Published: December 2022

Abstract
In massive multiple-input multiple-output (MIMO) systems, the knowledge of the users’ channel covariance matrix is crucial for minimum mean square error (MMSE) channel estimation in the uplink as well as it plays an important role in several multiuser beamforming schemes in the downlink. Due to the large number of base station antennas, accurate covariance estimation is challenging especially in the case where the number of samples is limited and thus comparable to the channel vector dimension. As a result, the standard sample covariance estimator may yield a too large estimation error which in turn may yield significant system performance degradation with respect to the ideal channel covariance knowledge case. To address such problem, we propose a method based on a parametric representation of the channel angular scattering function. The proposed parametric representation includes a discrete specular component which is addressed using the well-known MUltiple SIgnal Classification (MUSIC) method, and a diffuse scattering component, which is modeled as the superposition of suitable dictionary functions. To obtain the representation parameters we propose two methods, where the first solves a non-negative least-squares problem and the second maximizes the likelihood function using expectationmaximization. Our simulation results show that the proposed methods outperform the state-of-the-art with respect to various estimation quality metrics and different sample sizes.
Alterations of Lipid-Mediated Mitophagy Result in Aging-Dependent Sensorimotor Defects
Authors: Natalia Oleinik , Albayram Onder , Kassir Mohamed Faisal , Atilgan Firdevs , Walton Chase , Karakaya Eda , Kurtz John , Alekseyenko Alexander Vladimirovich , Alsudani Habeeb , Szulc Zdzislaw , Ogretmen Besim 
Published: December 2022

Abstract
The metabolic consequences of mitophagy alterations due to age-related stress in healthy aging brains vs. neurodegeneration remain unknown. Here, we demonstrate that ceramide synthase 1 (CerS1) is transported to the outer mitochondrial membrane (OMM) by the p17/PERMIT transporter that recognizes mislocalized mitochondrial ribosomes (mitoribosomes) via 39-FLRN-42 residues, inducing ceramide-mediated mitophagy. P17/PERMIT-CerS1-mediated mitophagy attenuated the argininosuccinate/fumarate/malate axis and induced D-glucose and fructose accumulation in neurons in culture, and brain tissues (primarily in the cerebellum) of wild-type mice in vivo. These metabolic changes in response to sodium-selenite were nullified in the cerebellum of CerS1top/top, PARKIN-/- or p17/PERMIT-/- mice that have dysfunctional mitophagy. Whereas sodium selenite induced mitophagy in the cerebellum, and improved motor-neuron deficits in aged wild-type mice, exogenous fumarate or malate prevented mitophagy. Attenuation of ceramide-mediated mitophagy enhanced damaged mitochondria accumulation and age-dependent sensorimotor abnormalities in p17/PERMIT-/- mice. Reinstituting mitophagy using a ceramide analog drug with selenium conjugate, LCL768, restored mitophagy and reduced malate/fumarate metabolism, improving sensorimotor deficits in old p17/PERMIT-/- mice. Thus, these data describe metabolic consequences of alterations to P17/PERMIT/ceramide-mediated mitophagy associated with the loss of mitochondrial quality control in the brain and provide therapeutic options to overcome age-dependent sensorimotor deficits and related disorders like amyotrophic lateral sclerosis (ALS).