bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the theoretical risk of cross‐reactivity among recently identified food allergens for dogs
Authors: Olivry Thierry , O'Malley Andrea , Chruszcz Maksymilian 
Published: August 2022

AbstractBackgroundThere is increasing evidence of cross‐reactivity between allergens of close or distant species. The A‐RISC (Allergens'–Relative Identity, Similarity and Cross‐reactivity) index helps evaluate the risk of theoretical cross‐reactivity between proteins of the same family among different species.ObjectivesTo report the A‐RISC indices for several food allergens of dogs between multiple food sources.Materials and MethodsWe selected several recently characterised food allergens for dogs from fish and chicken (ACTA1, ALDOA, CKM, ENO3, GAPDH, PKM and TPI1), fish (TPM1/2), beef/lamb (PGM1) and corn/potato (WAXY). When quality sequence data were available, A‐RISC indices were calculated between multiple animal and plant species that can be used as food sources. For the TPM subunits, A‐RISC indices also were calculated with the environmental allergens Bla g 4 and Der f 10, and the Toxocara canis nematode.ResultsThe A‐RISC indices suggest a substantial theoretical risk of cross‐reactivity between species for all allergens considered. For TPM, this risk also extends to the environmental and nematode allergens.Conclusions and clinical relevanceThere is a high theoretical risk of cross‐reactivity between allergens of different species used as food sources. The clinical relevance of these elevated A‐RISC indices should be studied further.
Protein kinase C‐mediated phosphorylation of transient receptor potential melastatin type 2 Thr738 counteracts the effect of cytosolic Ca2+ and elevates the temperature threshold
Authors: Kashio Makiko , Masubuchi Satoru , Tominaga Makoto 
Published: August 2022

AbstractThe transient receptor potential melastatin type 2 (TRPM2) channel is a non‐selective cation channel that has high Ca2+ permeability. TRPM2 is sensitive to warm temperatures and is expressed in cells and tissues that are maintained at core body temperature. TRPM2 activity is also regulated by endogenous factors including redox signalling, cytosolic Ca2+ and adenosine diphosphate ribose. As a result of its wide expression and function at core body temperature, these endogenous factors could regulate TRPM2 activity at body temperature under physiological and pathophysiological conditions. We previously reported that cellular redox signalling can lower TRPM2 temperature thresholds, although the mechanism that regulates these thresholds is unclear. Here, we used biochemical and electrophysiological techniques to explore another regulatory mechanism for TRPM2 temperature thresholds that is mediated by TRPM2 phosphorylation. Our results show that: (1) the temperature threshold for TRPM2 activation is lowered by cytosolic Ca2+; (2) protein kinase C‐mediated phosphorylation of TRPM2 counteracts the effect of cytosolic Ca2+; and (3) Thr738 in mouse TRPM2 that lies near the Ca2+ binding site in the cytosolic cleft of the transmembrane domain is a potential phosphorylation site that may be involved in phosphorylation‐mediated elevation of TRPM2 thresholds. These findings provide structure‐based evidence to understand how temperature thresholds of thermo‐sensitive TRP channels (thermo‐TRPs) are determined and regulated.
imageKey points
The transient receptor potential melastatin type 2 (TRPM2) ion channel is temperature‐sensitive and Ca2+‐permeable.
Endogenous factors and pathways such as redox signalling can regulate TRPM2 activity at body temperature under physiological and pathophysiological conditions.
In the present study, we report the novel finding that cytosolic Ca2+ lowers the temperature threshold for TRPM2 activation in a concentration‐dependent manner.
Protein kinase C‐mediated phosphorylation of TRPM2 at amino acid Thr782 elevates the temperature threshold for activation by counteracting the effects of cytosolic Ca2+.
These findings provide structure‐based evidence to understand how temperature thresholds of thermo‐sensitive TRP channels are determined and regulated.
Sublithospheric melt input in cratonic lamproites
Authors: Sarkar Soumendu , Giuliani Andrea , Phillips David , Howarth Geoffrey H. , Ghosh Sujoy , Dalton Hayden 
Published: August 2022

AbstractCratonic lamproites are diamondiferous ultrapotassic rocks that are emplaced through thick continental lithosphere and thought to derive from melting of metasomatized (i.e., geochemically enriched) regions of the subcontinental lithospheric mantle (SCLM). We explored the alternative hypothesis that melts sourced from sublithospheric (i.e., convective mantle) sources dominate the genesis of cratonic lamproites. Supporting evidence includes a robust linear correlation between the Mg/Fe ratios of xenocrystic and magmatic olivine in lamproites worldwide, overlapping the trend observed for kimberlite olivine. This indicates that, similar to kimberlites, primary lamproite melts originate from broadly similar sublithospheric mantle sources before assimilating SCLM material of variable composition. The lamproites are also characterized by a direct correlation between olivine Mg/Fe ratio and bulk-lamproite K2O/Al2O3, an index of potassium enrichment in the melt that is independent of mantle-xenocryst entrainment and magmatic differentiation. Quantitative modeling indicates that this correlation results from the interaction between carbonate-bearing sublithospheric melt and phlogopite-rich wall rocks in the SCLM. Our data show that cratonic lamproites and kimberlites have similar mantle sources in the convective mantle, with lamproites acquiring their peculiar enrichment in K by interaction with metasomatized SCLM en route to the surface. Modification of sublithospheric melts during transit through the continental lithosphere might represent a common process for the genesis of alkaline mafic/ultramafic magmas.
Association between use of systemic and inhaled glucocorticoids and changes in brain volume and white matter microstructure: a cross-sectional study using data from the UK Biobank
Authors: van der Meulen Merel , Amaya Jorge Miguel , Dekkers Olaf M , Meijer Onno C 
Published: August 2022

ObjectiveTo test the hypothesis that systemic and inhaled glucocorticoid use is associated with changes in grey matter volume (GMV) and white matter microstructure.DesignCross-sectional study.SettingUK Biobank, a prospective population-based cohort study of adults recruited in the UK between 2006 and 2010.ParticipantsAfter exclusion based on neurological, psychiatric or endocrinological history, and use of psychotropic medication, 222 systemic glucocorticoid users, 557 inhaled glucocorticoid users and 24 106 controls with available T1 and diffusion MRI data were included.Main outcome measuresPrimary outcomes were differences in 22 volumetric and 14 diffusion imaging parameters between glucocorticoid users and controls, determined using linear regression analyses adjusted for potential confounders. Secondary outcomes included cognitive functioning (six tests) and emotional symptoms (four questions).ResultsBoth systemic and inhaled glucocorticoid use were associated with reduced white matter integrity (lower fractional anisotropy (FA) and higher mean diffusivity (MD)) compared with controls, with larger effect sizes in systemic users (FA: adjusted mean difference (AMD)=−3.7e-3, 95% CI=−6.4e-3 to 1.0e-3; MD: AMD=7.2e-6, 95% CI=3.2e-6 to 1.1e-5) than inhaled users (FA: AMD=−2.3e-3, 95% CI=−4.0e-3 to −5.7e-4; MD: AMD=2.7e-6, 95% CI=1.7e-7 to 5.2e-6). Systemic use was also associated with larger caudate GMV (AMD=178.7 mm3, 95% CI=82.2 to 275.0), while inhaled users had smaller amygdala GMV (AMD=−23.9 mm3, 95% CI=−41.5 to −6.2) than controls. As for secondary outcomes, systemic users performed worse on the symbol digit substitution task (AMD=−0.17 SD, 95% CI=−0.34 to −0.01), and reported more depressive symptoms (OR=1.76, 95% CI=1.25 to 2.43), disinterest (OR=1.84, 95% CI=1.29 to 2.56), tenseness/restlessness (OR=1.78, 95% CI=1.29 to 2.41), and tiredness/lethargy (OR=1.90, 95% CI=1.45 to 2.50) compared with controls. Inhaled users only reported more tiredness/lethargy (OR=1.35, 95% CI=1.14 to 1.60).ConclusionsBoth systemic and inhaled glucocorticoid use are associated with decreased white matter integrity and limited changes in GMV. This association may contribute to the neuropsychiatric side effects of glucocorticoid medication, especially with chronic use.
Electrophoretic mobility of individual molecules of alkaline phosphatase
Authors: Craig Douglas B , Malhi Simrat , Ahmad Basit , Breckman Kristopher , Patel Ankoor 
Published: August 2022

The electrophoretic mobilities and catalytic rates of individual molecules of bovine intestinal alkaline phosphatase were determined in CHES and borate buffers of identical pH using a capillary electrophoresis based method. Both properties were found to be heterogeneous. In the presence of CHES, the mobility and rate were found to be −1.9 ± 0.2 × 10−9 m2 V−1 s−1 and 9.8 ± 7.4 × 104 min−1 ( N = 38), respectively. In the presence of borate, the mobility and rate were found to be −6.9 ± 0.5 × 10−9 m2 V−1 s−1 and 2.0 ± 1.3 × 104 min−1 ( N = 41), respectively. The means and variances for both properties were found to differ significantly between the two buffers. The difference in average mobility was attributed to an increase in negative charge caused by borate complexing with the carbohydrate moieties attached to the enzyme. The difference in variance was attributed to heterogeneous complexation with borate due to heterogeneity in the glycosylation. The differences in mean values for the catalytic rate were attributed to the inhibitory effect of borate and the difference in variance may suggest that the KI of this binding may also be heterogeneous.
Using telomeric length measurements and methylation to understand the karyotype diversification of Ctenomys minutus (a small fossorial mammal)
Authors: Matzenbacher C.A. , Da Silva J. , Garcia A.L.H. , Kretschmer R. , Cappetta M. , de Oliveira E.H.C. , de Freitas T.R.O. 
Published: August 2022

The genus Ctenomys has been widely used in karyotype evolution studies due to the variation in their diploid numbers. Ctenomys minutus is characterized by intraspecific variation in diploid number (2 n = 42, 46, 48, and 50), which makes it an interesting model to investigate genomic rearrangements mechanisms that could lead to different cytotypes in this species. Thereupon, it has been already shown that DNA methylation may participate in chromosome structure. Therefore, we aimed to investigate whether telomeres and global DNA methylation had a role in the genome rearrangements that led to this variation in C. minutus. We also realized an analysis for the presence of intrachromosomal telomeric repeats (ITRs) by fluorescence in situ hybridization. Our study demonstrated that neither telomere length nor DNA methylation had significant differences among the cytotypes. However, if only females were considered, there were significant differences for telomere length and methylation. Young individuals, regardless of their cytotypes, had the most methylated DNA. Regarding the ITRs, we found a signal on chromosome 1 in 2 n = 50b. No evidence was found that telomere length or methylation could have influenced chromosomal rearrangements, although new cytotypes seem to have emerged within the distribution of parental cytotypes by the accumulation of different chromosomal rearrangements.
Running vacuum versus holographic dark energy: a cosmographic comparison
Authors: Rezaei Mehdi , Peracaula Joan Solà 
Published: August 2022

AbstractWe perform a comparative study of different types of dynamical dark energy models (DDEs) using the cosmographic method. Among the models being examined herein we have the Running Vacuum models (RVMs), which have demonstrated considerable ability to fit the overall cosmological data at a level comparable to the standard cosmological model,$$\Lambda $$ΛCDM, and capable of alleviating the$$\sigma _8$$σ8and$$H_0$$H0tensions. At the same time we address a variety of Holographic dark energy models (HDEs) with different options for the time (redshift)-varying model parameter$$c=c(z)$$c=c(z). We deal with the HDEs under the double assumption of fixed and evolving holographic length scale and assess which one is better. Both types of DDEs (RVMs and HDEs) are confronted with the most robust cosmographic data available, namely the Pantheon sample of supernovae data (SnIa), the baryonic acoustic oscillations data (BAOs) extracted from measurement of the power spectrum and bispectrum of the BOSS data release, and the cosmic chronometer measurements of the Hubble rate (CCHs) at different redshifts obtained from spectroscopic observations of passively evolving galaxies. Using these data samples we assess the viability of the mentioned DDEs and compare them with the concordance$$\Lambda $$ΛCDM model. From our cosmographic analysis we conclude that the RVMs fare comparably well to the$$\Lambda $$ΛCDM, a fact which adds up more credit to their sound phenomenological status. In contrast, while some of the HDEs are favored using the current Hubble horizon as fixed holographic length, they become highly unfavoured in the more realistic case when the holographic length is dynamical and evolves as the Hubble horizon.
Phenomenology analysis of $$\bar{B}^* \rightarrow V \tau ^-\bar{\nu }_{\tau }$$ decays in and beyond the Standard Model
Authors: Sheng Jin-Huan , Hu Quan-Yi , Wang Ru-Min , Zhu Jie 
Published: August 2022

AbstractMotivated by the persistent anomalies reported in the$$b\rightarrow c \tau \bar{\nu }$$b→cτν¯data, we investigate the semileptonic decays$$\bar{B}^* \rightarrow V \tau ^-\bar{\nu }_{\tau } (V=D^*_{u,d,s},J/\psi )$$B¯∗→Vτ-ν¯τ(V=Du,d,s∗,J/ψ), within the Standard Model and beyond. The relevant transition form factors, being calculated in the covariant light-front quark model, is the main source of theoretical uncertainties. Using various best-fit solutions for the new operator Wilson coefficients, we report numerical results on various observables related to the processes$$\bar{B}^* \rightarrow V \tau ^-\bar{\nu }_{\tau }$$B¯∗→Vτ-ν¯τ, such as the branching ratios, the ratio of branching fractions, the hadron and lepton polarization asymmetries, the forward–backward asymmetries and the convexity parameter. We also predict the$$q^2$$q2distribution of these observables both within the Standard Model and in various new physics scenarios. The accessible observables are studied in order to assess their sensitivity to the different new physics scenarios. We can find that some of the new physics scenarios can be differentiated from each other by using these observables and their correlations. We also find that some observables of these decay modes are sizeable and deviate significantly (for new physics coupling parameter$$S_R$$SRespecially) from their corresponding standard model values, which are expected to be within the reach of Run III of Large Hadron Collider experiment. And experimental information on these distributions which will be testified in the future can help to disentangle the dynamical origin of the current anomalies.
Conserved relativistic Ertel’s current generating the vortical and thermodynamic aspects of space–time
Authors: Sakuma Hirofumi , Ojima Izumi , Saigo Hayato , Okamura Kazuya 
Published: August 2022

Motivated by Aoki et al.’s recent research on conserved charges and entropy current, we reinvestigated the conservation of relativistic Ertel’s current, which has received little attention outside the field of geophysical fluid dynamics. Ertel’s charge is an important indicator of the correlation between vortex vectors and entropy gradient fields in Earth’s meridional heat transport. We first show that in the generalized Hamiltonian structure of baroclinic fluids, the duality between the total energy and the Casimir as a function of Ertel’s charge plays an important role in the nonrelativistic case. Then, by extending the result to relativistic cases, we show that this finding has far-reaching implications not only for space–time issues in cosmology but also for the foundation of quantum field theory. An especially important finding is that, as an unreported dual form of the Einstein field equation, we identify a special equation satisfied not only by the vortex tensor field generated by the conserved charge but also by the Weyl tensor in interpreting the physical nature of the metric tensor [Formula: see text], which appears in the cosmological term [Formula: see text].
The dynamics of delayed models for interactive wild and sterile mosquito populations
Authors: Wang Juan , Yue Peixia , Cai Liming 
Published: August 2022

The sterile insect technique (SIT) has been applied as an alternative method to reduce or eradicate mosquito-borne diseases. To explore the impact of the sterile mosquitoes on controlling the wild mosquito populations, in this paper, we further extend the work in [J. Li, New revised simple models for interactive wild and sterile mosquito populations and their dynamics, J. Biol. Dyn. 11(S2) (2017) 316–333] and formulate delayed models for interactive wild and sterile mosquitoes, which can depict wild mosquito population undergoing distinct stages of development during a lifetime. By performing mathematical analysis, the threshold dynamics of the proposed models are explored, respectively. In particular, Hopf bifurcation phenomena are observed as the delay [Formula: see text] is varying. Numerical examples illustrate our findings.
Time Series Compression Survey
Authors: Chiarot Giacomo , Silvestri Claudio 
Published: August 2022

Smart objects are increasingly widespread and their ecosystem, also known as the Internet of Things (IoT), is relevant in many application scenarios. The huge amount of temporally annotated data produced by these smart devices demands efficient techniques for the transfer and storage of time series data. Compression techniques play an important role toward this goal and, even though standard compression methods could be used with some benefit, there exist several ones that specifically address the case of time series by exploiting their peculiarities to achieve more effective compression and more accurate decompression in the case of lossy compression techniques. This article provides a state-of-the-art survey of the principal time series compression techniques, proposing a taxonomy to classify them considering their overall approach and their characteristics. Furthermore, we analyze the performances of the selected algorithms by discussing and comparing the experimental results that were provided in the original articles.
The goal of this article is to provide a comprehensive and homogeneous reconstruction of the state-of-the-art, which is currently fragmented across many articles that use different notations and where the proposed methods are not organized according to a classification.
Polynomial-time trace reconstruction in the smoothed complexity model
Authors: Chen Xi , De Anindya , Lee Chin Ho , Servedio Rocco A. , Sinha Sandip 
Published: August 2022

In the
trace reconstruction problem
, an unknown source string
x
∈ {0, 1}

n

is sent through a probabilistic
deletion channel
which independently deletes each bit with probability
δ
and concatenates the surviving bits, yielding a
trace
of
x
. The problem is to reconstruct
x
given independent traces. This problem has received much attention in recent years both in the worst-case setting where
x
may be an arbitrary string in {0, 1}

n

[DOS19, NP17, HHP18, HL20, Cha21a, Cha21b] and in the average-case setting where
x
is drawn uniformly at random from {0, 1}

n

[PZ17, HPP18, HL20, Cha21a, Cha21b].

This paper studies trace reconstruction in the
smoothed analysis
setting, in which a “worst-case” string
x
worst
is chosen arbitrarily from {0, 1}

n

, and then a perturbed version x of
x
worst
is formed by independently replacing each coordinate by a uniform random bit with probability
σ
. The problem is to reconstruct x given independent traces from it.

Our main result is an algorithm which, for any constant perturbation rate 0 <
σ
< 1 and any constant deletion rate 0 <
δ
< 1, uses poly(
n
) running time and traces and succeeds with high probability in reconstructing the string x. This stands in contrast with the worst-case version of the problem, for which

\(\text{exp}(\tilde{O}(n^{1/5})) \)

is the best known time and sample complexity [Cha21b].

Our approach is based on reconstructing x from the multiset of its short subwords and is quite different from previous algorithms for either the worst-case or average-case versions of the problem. The heart of our work is a new poly(
n
)-time procedure for reconstructing the multiset of all
O
(log
n
)-length subwords of any source string
x
∈ {0, 1}

n

given access to traces of
x
.
Liposome-Encapsulated Bioactive Guttiferone E Exhibits Anti-Inflammatory Effect in Lipopolysaccharide-Stimulated MH-S Macrophages and Cytotoxicity against Human Cancer Cells
Authors: Dzoyem Jean Paul , Pinnapireddy Shashank Reddy , Fouotsa Hugues , Brüßler Jana , Runkel Frank , Bakowsky Udo 
Published: August 2022

Background. Guttiferone E is a naturally occurring polyisoprenylated benzophenone exhibiting a wide range of remarkable biological activities. But its therapeutic application is still limited due to its poor water solubility. This study is aimed at preparing guttiferone E-loaded liposomes and assessing their in vitro cytotoxicity and anti-inflammatory effect. Methods. Liposomes containing guttiferone E were prepared by the thin film hydration method, and the physicochemical characteristics were determined using dynamic light scattering, laser Doppler velocimetry, and atomic force microscopy. The cytotoxicity was assessed by the MTT assay. The fluorometric cyclooxygenase (COX) activity assay kit was used to assess the COX activity while the nitric oxide production was evaluated by the Griess reagent method. Results. The liposomes with a mean size of

183.33
±
17.28

nm

were obtained with an entrapment efficiency of 63.86%. Guttiferone E-loaded liposomes successfully decreased the viability of cancer cells. The overall IC50 values varied between 5.46 μg/mL and 22.25 μg/mL. Compared to the untreated control, guttiferone E-loaded liposomes significantly reduced the nitric oxide production and the activity of COX in a concentration-dependent manner. Conclusion. This study indicates that liposomes can be an alternative to overcome the water insolubility issue of the bioactive guttiferone E.
Vírus em viagem: fluxos turísticos globais e propagação pandémica da Covid-19
Authors: Sacramento Octávio 
Published: August 2022

Na relação com a Covid-19, o turismo é referenciado sobretudo como uma esfera socioeconômica severamente afetada, não sendo dado o devido relevo ao seu papel enquanto componente do sistema de condições que desencadeou a pandemia. Perante esta situação, a análise desenvolvida é orientada pelo intuito de perceber como os processos de massificação turística e a abrangente rede de transporte aéreo que pressupõem, gerando conectividades, trânsitos e velocidade sistêmica, contribuíram para a súbita globalização do Sars-CoV-2. Para tal são mobilizados dados resultantes de um processo de pesquisa de teor documental em fontes mediáticas, fontes associadas a grandes instituições internacionais de natureza intergovernamental e fontes científicas. A partir desses dados é possível depreender-se que os contextos turísticos e as respectivas estruturas de mobilidade são o resultado de complexas assemblagens mais- do-que-humanas nas quais emergem condições sociais, ambientais e tecnológicas que funcionam como poderosos vetores estruturais de rápida difusão transnacional de biocontaminantes, responsáveis, em alguns casos, por cenários pandêmicos como aquele em que vivemos desde março de 2020.