bluuebunny/crossref_metadata_2025_split huggingface dataset:
What role can education play in integrated care? Lessons from the ECHO (Extensions for Community Health Outcomes) Concussion program
Authors: Zhao Q. Jane , Cupido Nathan , Whitehead Cynthia R. , Mylopoulos Maria 
Published: July 2022

PurposeDesign, implementation, and evaluation are all important for integrated care. However, they miss one critical factor: education. The authors define “integrated care education” as meaningful learning that purposefully supports collaboration and the development of adaptive expertise in integrated care. The ECHO (Extensions for Community Health Outcomes) model is a novel digital health solution that uses technology-enabled learning (TEL) to facilitate, support, and model integrated care education. Using ECHO Concussion as a case study, the authors describe the effects of technology-enabled integrated care education on the micro-, meso-, and macro-dimensions of integrated care.Design/methodology/approachThis case study was constructed using data extracted from ECHO Concussion from video-archived sessions, participant observation, and internal program evaluation memos. The research team met regularly to discuss the development of relevant themes to the dimensions of integrated care.FindingsOn the micro-level, clinical integration occurs through case-based learning and the development of adaptive expertise. On the meso-level, professional integration is achieved through the development of the “specialist generalist,” professional networks and empathy. Finally, on the macro-level, ECHO Concussion and the ECHO model achieve vertical and horizontal system integration in the delivery of integrated care. Vertical integration is achieved through ECHO by educating and connecting providers across sectors from primary to quaternary levels of care. Horizontal integration is achieved through the establishment of lateral peer-based networks across sectors as a result of participation in ECHO sessions with a focus on population-level health.Originality/valueThis case study examines the role of education in the delivery of integrated care through one program, ECHO Concussion. Using the three dimensions of integrated care on the micro-, meso-, and macro-levels, this case study is the first explicit operationalization of ECHO as a means of delivering integrated care education and supporting integrated care delivery.
Reflections and predictions on effects of COVID-19 pandemic on retailing
Authors: Verhoef Peter C. , Noordhoff Corine S. , Sloot Laurens 
Published: July 2022

PurposeThe Covid-19 pandemic has a strong effect on societies, business and consumers. Governments have taken measures to reduce the spread of the pandemic, such as social distancing and lockdowns. The latter has also resulted in a temporary closure of physical stores for “non-essential” retailing. Covid-19 thus has a profound impact on how people live. The period of relative isolation, social distancing and economic uncertainty changes the way we behave. New consumer behaviors span all areas of life, from how we work to how we shop to how we entertain ourselves. These shifts have important implications for retailers. This paper aims to discuss the potential structural effect on shopping behavior and retailing when Covid-19 measures are no longer needed and society moves back to a normal situation.Design/methodology/approachThe paper synthesizes empirical and conceptual literature on the consequences of COVID-19 and introduces a conceptual framework along with a set of predictions that can be investigated with empirical data.FindingsThis study suggests that Covid-19 shapes both consumer needs and behavior and how retailers respond to these changes. Moreover, it suggests that this will not only affect market outcomes (i.e. retail sales and market share online) but also firm outcomes (i.e. customer experience, firm sales) and importantly the competition between online and offline retailers.Originality/valueIn the conceptual framework, this study aims to advance knowledge on longer-term outcomes (vs immediate outcomes such as panic buying) and how COVID-19 is changing the competitive landscape of retail.
Seismic data augmentation for automatic fault picking using deep learning
Authors: Pham Nam , Fomel Sergey 
Published: July 2022

AbstractWe propose a method to generate seismic images with corresponding fault labels for augmenting training data in automatic fault detection. Our method is based on two generative adversarial networks: one for creating a fault system and the other for generating two‐dimensional seismic images with faults as a condition. Our method can capture the characteristics of field seismic data during inference to generate samples that have properties of both field seismic data and synthetic training data. We then use the newly generated seismic images with corresponding fault labels to train a convolutional neural network for fault picking. We test the proposed approach on a three‐dimensional field dataset from the Gulf of Mexico. We use different areas in the field dataset as input to generate new training data for corresponding fault‐picking models. The results show that the generated training data from our method help in improving the fault‐picking models in the targeted areas.
The impact of regional trade policy uncertainty on the productivity of Chinese export enterprises: The case of China–ASEAN Free Trade Area
Authors: Zhou Kexuan , Yu Linhui , Jiang Xinlin , Kumar Sanjay 
Published: July 2022

AbstractReduction of regional trade policy uncertainty is critical for promoting Chinese export enterprise productivity and will help the economy enter the high‐quality development stage. We use the case of the China–ASEAN Free Trade Area to empirically tests the impact of the reduction of regional trade policy uncertainty on the productivity of Chinese export enterprises. We apply the difference‐in‐difference method to micro‐enterprise level data from the “China industrial enterprise database” and “China Customs enterprise database” for 2007–2013. Our analysis and results show that establishing the China–ASEAN Free Trade Area has dramatically reduced regional trade policy uncertainty, significantly impacting the productivity of Chinese enterprises exporting to ASEAN. The results also show that enterprises with different ownership types, regions, factor density, and pollution emission intensity show significant heterogeneity in the level of productivity improvement. Applying a mechanism test, we found that the promotion of productivity from a reduction of regional trade policy uncertainty is achieved through the learning effect, the competition effect, and improving the trade environment of imported intermediate goods. The learning effect mechanism has the highest contribution, accounting for 39.01% of the net effect. The empirical results provide novel insight into promoting the productivity of Chinese enterprises exporting to ASEAN from the perspective of reducing regional trade policy uncertainty.
Roof‐dependent atrial flutter with epicardial conduction pathway masked by left atrium posterior wall debulking ablation
Authors: Ishimura Masayuki , Yamamoto Kayo , Yamamoto Masashi , Himi Toshiharu , Kobayashi Yoshio 
Published: July 2022

AbstractRoof‐dependent atrial flutter (AFL) is a major tachyarrhythmia rotating in the left atrium (LA). Here, we describe a case of roof‐dependent AFL during atrial fibrillation ablation. LA posterior wall (LAPW) debulking ablation was performed before the induction. Atrial tachycardia (AT) was induced by burst pacing, and the 3D mappings showed a focal pattern from the LA inferior area. The post‐pacing interval from the roof and bottom line corresponded to the AT cycle length. The LAPW debulking ablation masked roof‐dependent AFL due to the lack of endocardium potentials in the LAPW. We report that roof‐dependent AFL connected by epicardium fibers.
The costs of ideological prosociality: Analyses of the EuropeanSocialSurvey from 2002 to 2018 find negative relationships between endorsing universalistic values and well‐being and social capital
Authors: Nezlek John B. 
Published: July 2022

AbstractTraditionally, prosociality has been conceptualized in terms of the interpersonal domain, for example, helping behavior. Nevertheless, people can be prosocial in terms of ideological domains, for example, social policies they support. The present study examined the utility of distinguishing interpersonal and ideological prosocial values as predictors of well‐being and social capital. Data from nine European Social Surveys were combined. TheUniversalismandBenevolencevalues of Schwartz's basic human values were treated as measures of ideological and interpersonal prosocial values. Relationships betweenUniversalismandBenevolenceand well‐being and social capital were examined with multilevel models, persons nested with rounds, rounds nested within countries. Respondent sex, age, and education were included as covariates. These analyses found thatBenevolencewas positively related to satisfaction with life and happiness, whereasUniversalismwas negatively related to satisfaction with life and happiness. Although endorsing both values was positively related to attitudinal measures of social capital (e.g., people can be trusted),Universalismwas negatively related to self‐reports of social activity, whereasBenevolencewas either positively related or unrelated to self‐reports of social activity. Being ideologically prosocial appears to be associated with reduced well‐being. Future research is needed to explain the mechanisms responsible for this relationship.
Changes in flourishing from adolescence to young adulthood: An 8‐year follow‐up
Authors: Palmer Ashley N. , Patel Mansi , Narendorf Sarah C. , Sledge Shellye , Sanchez Katherine 
Published: July 2022

AbstractMost research on mental health among adolescents and young adults concentrates on understanding mental illness. However, mental health is more than the absence of mental illness. Among adolescents and young adults, positive mental health—a combination of emotional, social and psychological well‐being—is related to higher prosocial behaviour, school integration and self‐concept. However, much of the research on positive mental health among young adults has been with college students. Limited research has examined the presence and correlates of positive mental health, or flourishing, among a nationally representative sample of US young adults. This study extended from another researcher's original examination of positive mental health among US adolescents to describe the prevalence of flourishing among these same individuals in young adulthood. Our sample included 1090 individuals from the 2011 Panel Study of Income Dynamics Transition into Adulthood Supplement. Univariate and bivariate tests were used to describe the prevalence of flourishing during young adulthood and changes from adolescence to young adulthood. We used multivariable logistic regression to examine the relationships among indicators of healthy development and flourishing. Results suggest that flourishing improved during the transition into young adulthood and that targeting factors like life skills and civic engagement may enhance flourishing.
Opposite roles of Kindlin orthologs in cell survival and proliferation
Authors: Zhevlakova Irina , Xiong Luyang , Liu Huan , Dudiki Tejasvi , Ciocea Alieta , Podrez Eugene , Byzova Tatiana V. 
Published: July 2022

AbstractObjectiveIt is unclear why adhesion‐dependent cells such as epithelium undergo anoikis without anchorage, while adhesion‐independent blood cells thrive in suspension. The adhesive machinery of these cells is similar, with the exception of Kindlin orthologs, Kindlin 2 (K2) and Kindlin 3 (K3). Here we address how Kindlins control cell survival and proliferation in anchorage‐dependent and independent cells.Material and MethodsTo demonstrate the opposite roles of Kindlin's in cell survival we utilized in vivo and in vitro models and K3 and K2 knockdown and knockin cells. We used human lymphocytes from the K3 deficient patients in tumour model, K3 knockout and knockin macrophages and K2 knockout and knockin MEF cells for experiments in under conditions of adhesion and in suspension.ResultsDepletion of K3 promotes cell proliferation and survival of anchorage‐independent cells regardless of cell attachment. In contrast, the absence of K2 in anchorage‐dependent cells accelerates apoptosis and limits proliferation. K3 deficiency promotes human lymphoma growth and survival in vivo. Kindlins' interaction with paxillin, is critical for their differential roles in cell anchorage. While disruption of K2‐paxillin binding leads to increased apoptosis, the lack of K3‐paxillin binding has an opposite effect in adhesion‐independent cells.ConclusionKindlin ortologs and their interaction to cytoskeletal protein paxillin define the mechanisms of anchorage dependence. Our study identifies the key elements of the cell adhesion machinery in cell survival and tumour metastasis, proposing possible targets for tumour treatment.
Protective Effects of Cannabis sativa on chemotherapy‐induced nausea in a rat: Involvement of CB1 receptors
Authors: Elgohary Rania , Salama Abeer , Omara Enayat A. 
Published: July 2022

AbstractCyclophosphamide is an anticancer and immunosuppressive agent used in the treatment of various malignancies but causing gastrointestinal distress. Cannabis sativa and its derivatives have been used for the treatment of human gastrointestinal disorders. A purpose of this study was to investigate the effect of C. sativa on nausea induced by cyclophosphamide in rats. The rats were divided into four groups (eight animals per group): Group 1: Normal control (saline i.p.). Group 2: Rats received cyclophosphamide (200 mg/kg i.p.) 3 consecutive days. Group 3 and 4: Rats received cyclophosphamide (200 mg/kg i.p.) across Days 1–7, and C. sativa (20 and 40 mg/kg s.c.) was administered on cyclophosphamide days 4–7. We examined intake of kaolin, normal food and changes in body weight, as an indicator of the emetic stimulus. Oxidative stress markers, antioxidant enzymes status, serotonin (5‐HT), dopamine, noradrenaline and CB1R levels were evaluated in the intestinal homogenate. Moreover, histopathological study was performed. Results showed that C. sativa ameliorates cyclophosphamide‐induced emesis by increasing in body weight and normal diet intake with a decrease in kaolin diet intake after 7 days. Moreover, C. sativa significantly decreases (serotonin) 5‐HT, dopamine and noradrenaline, as well as decreasing oxidative stress and inflammation. Administration of C. sativa significantly increased the expression of CB1R in intestinal homogenate. Treatment with C. sativa also improved the histological feature of an intestinal tissue. These results suggested that C. sativa possess antiemetic, antioxidant and anti‐inflammatory effects in chemotherapy‐induced nausea in rats by activating CB1R.
Intersectionality on screen. A coloniality perspective to understand popular culture representations of intersecting oppressions at work
Authors: Barthold Charles , Krawczyk Victor , Berti Marco , Priola Vincenza 
Published: July 2022

AbstractThe article examines popular culture representations of Global South migrants' work through combining a coloniality perspective with an intersectional analysis. In doing so, we analyze two award winning films depicting the experiences of women migrant workers (FatimaandBread and Roses) in France and the United States of America. The analysis reveals that representations of the effects of intersecting power structures should be understood as a dynamic phenomenon, embedded in different coloniality regimes. Furthermore, it shows how popular culture representations of oppression are multifaceted and reflect stereotyping but also the victims' responses to oppressive conditions. These are represented as opportunities for change, but can, sometimes, contribute to reproduce oppression. The article theorizes the social and discursive (re)production of intersecting oppressions in popular culture by embedding these within coloniality regimes. It discusses how this coloniality perspective can bring to the fore the complexity of intersecting oppressions and the limited, but significant, forms of agency exercised by colonial subjects.
Effect of COVID‐19 on hepatitis B and C virus countermeasures: Hepatologist responses from nationwide survey in Japan
Authors: Hussain Md Razeen Ashraf , Hiebert Lindsey , Sugiyama Aya , Ouoba Serge , Bunthen E , Ko Ko , Akita Tomoyuki , Kaneko Shuichi , Kanto Tatsuya , Ward John W. , Tanaka Junko 
Published: July 2022

AbstractAimAchieving hepatitis B virus (HBV) and hepatitis C virus (HCV) elimination requires continuous and sustained high volumes of diagnosis and treatment, which have been affected by the ongoing COVID‐19 pandemic. This study assessed the effects of COVID‐19 on hepatitis‐related services in Japan and compared Japan's situation with a global survey.MethodsWe conducted an online cross‐sectional questionnaire survey of hepatologists from the Japan Society of Hepatology from August to October 2021 by using the same questionnaire from which a survey was conducted globally to address the effects of COVID‐19 on hepatitis‐related services. Hepatologists responded based on own impressions of their affiliated institutions.ResultsIn total, 196 hepatologists participated from 35 prefectures including 49.5% in managerial positions. Approximately 40% survey participants reported a 1%–25% decline in HBV and HCV screening and confirmatory testing. In addition, 53.6% and 45.4% reported no decline in HBV and HCV treatment initiation, respectively. Comparing any level of decrease with the global survey, there was less of a decline observed in Japan for screening (HBV: 51% vs. 56.3%, HCV: 51% vs. 70.9%) and treatment initiation (HBV: 32.7% vs. 52.4%, HCV: 41.8% vs. 66%). However, patient anxiety/fear (67.4%) and loss of staff due to COVID‐19 (49.0%) were reported as challenges for resuming services to pre‐COVID‐19 levels.ConclusionAlthough in Japan all‐inclusive decline in HBV‐ and HCV‐related services were lower than in other countries, a greater decline was observed in HBV and HCV screening and diagnosis than in treatment initiation. Prolonged anxiety/fear among patients, and loss of staff and facilities from the COVID‐19 response activities must be addressed to achieve elimination of hepatitis by 2030.
Host stimulator of interferon genes is essential for the efficacy of anti‐programmed cell death protein 1 inhibitors in non‐small cell lung cancer
Authors: Zhou Li , Xu Qiuli , Huang Litang , Zhan Ping , Jin Jiajia , Ye Mingxiang , Liu Hongbing , Zhang Fang , Wang Zimu , Liu Jiaxin , Chen Cen , Han Hedong , Zhang Qun , Zhu Suhua , Ren Jianan , Lv Tangfeng , Song Yong 
Published: July 2022

AbstractThe stimulator of interferon genes (STING) pathway is important for anticancer immune responses. However, the relative contributions of host and tumour STING in anti‐programmed cell death protein 1 (anti‐PD‐1) inhibitor responses in non‐small cell lung cancer (NSCLC) are unknown. STING expression in tumour and blood was associated with anti‐PD‐1 therapy in NSCLC patients; Moreover, loss of PD‐1 inhibitor therapeutic potency was demonstrated in STING KO (knock out) splenocytes and STING KO mice. STING knock‐down in tumour cells had no effect. STING on CD8+ T cells and host cells, not tumour cells, correlated with clinical effect of anti‐PD‐1 therapy in NSCLC patients. Finally, adoptive transfer of CD8+ T cells restored PD‐1 inhibitor anticancer effects. STING in host cells but not in tumour cells mediates anti‐PD‐1 inhibitor responses in cancer immunotherapy and could be used to select advantageous NSCLC patients from immunotherapy.
Editorial: Schools on the frontline of suicide prevention
Authors: Kamody Rebecca C. , Bloch Michael H. 
Published: July 2022

The world has experienced an unprecedented mental health crisis associated with the COVID‐19 pandemic (Liu et al., 2020). After more than two years navigating the associated uncertainty and distress, the impact on youth mental health continues to be a pressing concern. Those in the mental health field, as well as the children and families plagued by its impact, are inundated with seeing firsthand the impact on youth’s functioning. This includes increases in depression and suicide (Asarnow & Chung, 2021; Manzar et al., 2021), and having to navigate siloes in care and often even an inability when in crisis to access a continuum of services (Zhai, 2021). This has highlighted the significant issues with accessibility of mental health care and inequitable access to care for youth mental health both in the United States and globally. We continue to experience daily the impact of insufficient resources for youth behavioral health. For those in the field who prioritize the need for more robust intervention approaches, the child mental health crisis associated with the pandemic has highlighted the need for us to develop more novel and innovative interventions.
Variation in the genomic basis of parallel phenotypic and ecological divergence in benthic and pelagic morphs of Icelandic Arctic charr (Salvelinus alpinus)
Authors: Brachmann Matthew K. , Parsons Kevin , Skúlason Skúli , Gaggiotti Oscar , Ferguson Moira 
Published: July 2022

AbstractSympatric adaptive phenotypic divergence should be underlain by genomic differentiation between subpopulations. When divergence drives similar patterns of phenotypic and ecological variation within species we expect evolution to draw on common allelic variation. We investigated divergence histories and genomic signatures of adaptive divergence between benthic and pelagic morphs of Icelandic Arctic charr. Divergence histories for each of four populations were reconstructed using coalescent modelling and 14,187 single nucleotide polymorphisms. Sympatric divergence with continuous gene flow was supported in two populations while allopatric divergence with secondary contact was supported in one population; we could not differentiate between demographic models in the fourth population. We detected parallel patterns of phenotypic divergence along benthic‐pelagic evolutionary trajectories among populations. Patterns of genomic differentiation between benthic and pelagic morphs were characterized by outlier loci in many narrow peaks of differentiation throughout the genome, which may reflect the eroding effects of gene flow on nearby neutral loci. We then used genome‐wide association analyses to relate both phenotypic (body shape and size) and ecological (carbon and nitrogen stable isotopes) variation to patterns of genomic differentiation. Many peaks of genomic differentiation were associated with phenotypic and ecological variation in the three highly divergent populations, suggesting a genomic basis for adaptive divergence. We detected little evidence for a parallel genomic basis of differentiation as most regions and outlier loci were not shared among populations. Our results show that adaptive divergence can have varied genomic consequences in populations with relatively recent common origins, similar divergence histories, and parallel phenotypic divergence.