bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Emisi Gas Buang Karbon Monoksida (CO) terhadap Derajat Kejenuhan dan Kecepatan pada Jalan Kol. Polisi M. Taher Kota Jambi
Authors: Alamsyah Syahrial Alfarisi , Nurdin Ade , Said Yulia Morsa 
Published: July 2022

Kota Jambi mengalami perkembangan pesat dibidang pembangunan salah satunya pada jalan Kolonel Polisi M. Taher. Di mana terdapat beberapa pusat kegiatan seperti pusat perdagangan elektronik, restoran, dan perkantoran. Yang mana membuat meningkatnya volume lalu lintas sehingga sering terjadi kemacetan pada daerah tersebut yang akan memberikan dampak negatif terhadap lingkungan di sekitar salah satunya berupa emisi gas buang karbon monoksida. Tujuan dari penelitian ini ialah untuk mengetahui pengaruh antara emisi gas buang karbon monoksida (CO) dengan derajat kejenuhan dan kecepatan. Penelitian ini membagi jalan menjadi 2 segmen. Yang mana segmen pertama sepanjang 500 m dan segmen kedua sepanjang 350 m. Metode yang digunakan dalam penelitian ini adalah dengan melakukan survei dan observasi lapangan dengan pengambilan data prilaku lalu lintas antara lain volume lalu lintas, derajat kejenuhan, kecepatan, dan emisi gas karbon monoksida (CO). Dilakukan selama 3 hari yaitu hari senin, hari kamis dan hari minggu dengan waktu pengambilan data yaitu pada pagi hari pukul 07.00-08.00 WIB, 11.00-12.00 WIB untuk waktu siang, dan 16.00-17.00 WIB untuk waktu sore yang mewakili waktu puncak kegiatan transportasi. Setelah data didapat kemudian dianalisis menggunakan metode analisis regresi dan korelasi untuk melihat pengaruh antara derajat kejenuhan dan kecepatan terhadap emisi gas buang karbon monoksida (CO). Hasil penelitian menunjukkan bahwa pada lokasi volume lalu lintas dan derajat kejenuhan tertinggi terjadi pada hari minggu pukul 11.00-12.00 WIB di segmen 1 yaitu 2163,2 smp/jam dan 0,82. Sedangkan kecepatan terendah dan karbon monoksida tertinggi terjadi pada hari dan waktu yang sama di segmen 1 yaitu 36,12 km/jam dan 2062,96 µg/Nm3. Di mana gas karbon monoksida (CO) pada lokasi masih di bawah baku mutu udara ambien sehingga masih dalam kategori aman. Pengaruh prilaku lalu lintas terhadap emisi gas buang karbon monoksida (CO) menunjukkan semakin meningkatnya volume lalu lintas dan derajat kejenuhan, semakin tinggi gas karbon monoksida (CO) yang dihasilkan sedangkan semakin meningkatnya kecepatan kendaraan, semakin rendah gas karbon monoksida (CO) yang dihasilkan.
Ozone disc nucleolysis as an alternative to open disc surgery for slip disc
Authors: Sardar K , Das G , Mahta P , Mallick S , Hubbard R 
Published: July 2022

Back pain associated with herniated disks has become an important and increasing general health problem, both in Bangladesh and across the world. After all methods of conservative treatment have been exhausted, nucleolysis may be a minimally invasive alternative to surgery. In nucleolysis, chondrolytic substances, or other substances which reduce the pressure within the disk by other means, are injected into the nucleus pulposus under CT or C-arm guidance. Among various substances, which have been employed for nucleolysis, an ozone-oxygen mixture appears to be very promising. The water-binding capacity of ozone results in a reduction of pain. Moreover, it has an anti-inflammatory effects and results in an increase of perfusion to the affected area. Ozone is converted into pure oxygen in the body and has a low allergic potential. Recent minimally invasive therapeutic methods such as percutaneous nucleotomy or laser treatment have not been shown to result in superior results compared with ozone nucleolysis.
JBSA 2012; 25(1): 32-35
O impacto do cyberbullying na saúde mental de crianças e adolescentes durante a pandemia de COVID-19
Authors: Pereira Isabela Fernandes de Melo , Tissiani Amanda Apolori , Mendonça Gilberto José Góes de , Deininger Layza de Souza Chaves , Ramos André Luís Belmiro Moreira , Oliveira Márcya Cândida Casimiro de , Sousa Ana Luiza Dias Arruda da Silva , Minhoto Talita Barbosa 
Published: July 2022

Diante do contexto pandêmico, ocorreu aumento da vivência das pessoas no mundo virtual, sobretudo crianças e adolescentes. Com isso, surge a necessidade de identificar sinais de mau uso dessa ferramenta, bem como suas consequências no público em questão. Nesse sentido, esse trabalho busca analisar a literatura científica sobre o impacto do cyberbullying na saúde mental de crianças e adolescentes durante a pandemia de COVID-19. Quanto à metodologia, foi realizada uma revisão integrativa da literatura a partir da análise de artigos publicados entre 2020 e 2022, disponíveis nas bases de dados: Pubmed, BVS, Scielo e Lilacs. A questão norteadora do artigo foi: Qual o impacto do cyberbullying na saúde mental de crianças e adolescentes durante a pandemia de COVID-19? Os resultados encontrados foram o aumento significativo da incidência do cyberbullying entre crianças e adolescentes durante a pandemia de COVID-19, desencadeando consequências relevantea nessa população, sendo sintomas de ansiedade, depressão e ideação suicida as principais consequências dessa prática. Como conclusão, verificou-se que houve impacto significativo do cyberbullying na saúde mental de crianças e adolescentes durante a pandemia de COVID-19, sendo algumas opções de intervenção identificadas: a criação de aplicativo de interação com as vítimas e de programa escolar preventivo figuram entre as intervenções mais eficazes.
Cuidados paliativos e transplante de medula óssea: uma revisão integrativa da literatura
Authors: Vendramini Denise Maria , Oliveira-Cardoso Érika Arantes de 
Published: July 2022

Introdução: O Transplante de Medula Óssea (TMO) consiste em um tratamento de importante potencial curativo, o que desperta grande esperança em pacientes vivenciando doenças que exercem grave ameaça à continuidade da vida. Entretanto, tal tratamento é permeado por altos riscos, além da possibilidade de recaída da doença ainda existir após o mesmo, dessa forma, faz-se importante considerar abordagens de cuidado que abarquem essa imprevisibilidade, como os Cuidados Paliativos. Objetivo: Descrever quais as contribuições da abordagem de cuidados paliativos no transplante de medula óssea, que se caracteriza como um tratamento de proposta curativa a pacientes com doenças que exercem grave ameaça à continuidade da vida. Método: Revisão Integrativa da Literatura realizada nas bases de dados Scopus, PubMed, PsychINFO e LILACS, abarcando estudos de 2011 a 2021. Os estudos foram categorizados a partir da análise de conteúdo. Resultados: Após aplicação dos critérios de exclusão restaram seis estudos que compuseram o corpus deste trabalho. Resultados demonstraram que a integração precoce de cuidados paliativos ao cuidado padrão de TMO contribui significativamente para o manejo de sintomas físicos e emocionais, exploração de temáticas não abordadas por outros profissionais, como o enfrentamento do momento, bem como discussões sobre planejamento antecipado de cuidado. Conclusão: Os Cuidados Paliativos agregam inúmeros ganhos em relação ao cuidado do paciente submetido ao TMO. Nota-se, porém, a escassez de trabalhos envolvendo as duas temáticas e a necessidade de desenvolver novos estudos que possam fomentar essa prática dentro das clínicas de TMO.
HUBUNGAN PERSEPSI MAHASISWA DENGAN STRES AKADEMIK DALAM PEMBELAJARAN ONLINE DI MASA PANDEMI COVID-19
Authors: RIZKI ARIANI DWI SINTA 
Published: July 2022

ABSTRACT
Ariani, Dwi Sinta Rizki. 2021. The Correlation of Student’s Perception with Academic Stress in The Implementation of Online Learning in The Covid-19 Pandemic on Semester II Students of Widyagama Husada School of Health Malang. Thesis. Nursing Study Program of Widyagama Husada School of Health Malang. Advisors: (1) Miftakhul Ulfa, S.kep., Ners.,M.Kep. (2) Waifti Amalia, S.ST., M.Keb.
Background: Students as the most numerous individuals in educational institutions certainly feel the impact of the COVID-19 pandemic, where the learning system that is usually carried out face-to-face, either on campus or on practice location, has turned online. The stress experienced by the students during the study period may disturb students mindsets due to the complexity of the problems they face. The students are not only required to have technical expertise, but they are also required to have a certain attitude and mindsets so that the broad insights gained by students can be applied in their social environment.
Objectives: To find out the correlation between student perceptions and academic stress in the application of online learning during the COVID-19 pandemic for second semester students of STIKes Widyagama Husada Malang.
Research methods: The research design used in this study was descriptive correlation with a retrospective approach. The population in this study were second semester students of STIKes Widyagama Husada Malang. Samples were taken using a purposive sampling technique with a total of 80 respondents.
Research result: The results of the research indicated majority of second semester students of STIKes Widyagama Husada Malang experienced mild academic stress.
Conclusion: There is a correlation between student perceptions and academic stress in the application of online learning during the COVID-19 pandemic for second semester students of STIKes Widyagama Husada Malang.
References: 32 References (2010-2020)
Keywords: Student Perception, Academic Stress, Online Learning
Rethinking ‘Sex Robots’: Gender, Desire, and Embodiment in Posthuman Sextech
Authors: Locatelli Chloé 
Published: July 2022

This paper interrogates the posthuman potential of sextech aimed at heterosexual men, positing that advertising and design of products with digital femininities emphasise the possibility for emotional interaction. This work firstly applies pressure to the monolithic conceptualisation of ‘sex robots’, that impedes rigorously appraising existing sextech constructions. Applying posthuman theory to sextech, particularly critical posthumanism and the formative work of Donna Haraway, affords this investigation the theoretical rigour to reflect on the potential for emotional interaction with digital feminised others. Through digital media analysis, this paper explores three gendered-female technologies: Azuma Hikari, (2020); the RealdollX Application (2020) and VirtualMate (2020) alongside their concomitant promotional material. This research illustrates that the complex convergence of interactive technologies, digital feminities and emotive advertising suggests a shift into posthuman sextech – where digital feminities are designed and advertised as capable of providing erotic and emotive interaction.
A case–control study of infections caused by Klebsiella pneumoniae producing New Delhi metallo-beta-lactamase-1: Predictors and outcomes
Authors: Rodríguez-Noriega Eduardo , Garza-González Elvira , Bocanegra-Ibarias Paola , Paz-Velarde Beatriz Alejandra , Esparza-Ahumada Sergio , González-Díaz Esteban , Pérez-Gómez Héctor R. , Escobedo-Sánchez Rodrigo , León-Garnica Gerardo , Morfín-Otero Rayo 
Published: July 2022

IntroductionInfections caused by antimicrobial-resistant bacteria are a significant cause of death worldwide, and carbapenemase-producing bacteria are the principal agents. New Delhi metallo-beta-lactamase-1 producing Klebsiella pneumoniae (KP-NDM-1) is an extensively drug-resistant bacterium that has been previously reported in Mexico. Our aim was to conduct a case–control study to describe the risk factors associated with nosocomial infections caused by K. pneumoniae producing NDM-1 in a tertiary-care hospital in Mexico.MethodsA retrospective case–control study with patients hospitalized from January 2012 to February 2018 at the Hospital Civil de Guadalajara “Fray Antonio Alcalde” was designed. During this period, 139 patients with a culture that was positive for K. pneumoniae NDM-1 (cases) and 486 patients hospitalized in the same department and on the same date as the cases (controls) were included. Data were analyzed using SPSS v. 24, and logistic regression analysis was conducted to calculate the risk factors for KP-NDM-1 infection.ResultsOne hundred and thirty-nine case patients with a KP-NDM-1 isolate and 486 control patients were analyzed. In the case group, acute renal failure was a significant comorbidity, hospitalization days were extended, and significantly more deaths occurred. In a multivariate analysis of risk factors, the independent variables included the previous use of antibiotics (odds ratio, OR = 12.252), the use of a urinary catheter (OR = 5.985), the use of a central venous catheter (OR = 5.518), the use of mechanical ventilation (OR = 3.459), and the length of intensive care unit (ICU) stay (OR = 2.334) as predictors of infection with NDM-1 K. pneumoniae.ConclusionIn this study, the previous use of antibiotics, the use of a urinary catheter, the use of a central venous catheter, the use of mechanical ventilation, and ICU stay were shown to be predictors of infection with NDM-1 K. pneumoniae and were independent risk factors for infection with NDM-1 K. pneumoniae.
Distinct Cohorts of Aspergillus fumigatus Transcription Factors Are Required for Epithelial Damage Occurring via Contact- or Soluble Effector-Mediated Mechanisms
Authors: Rahman Sayema , van Rhijn Norman , Papastamoulis Panagiotis , Thomson Darren D. , Carter Zorana , Fortune-Grant Rachael , Rattray Magnus , Bromley Michael John , Bignell Elaine 
Published: July 2022

Damage to the lung epithelium is a unifying feature of disease caused by the saprophytic fungus Aspergillus fumigatus. However, the mechanistic basis and the regulatory control of such damage is poorly characterized. Previous studies have identified A. fumigatus mediated pathogenesis as occurring at early (≤ 16 hours) or late (&gt;16 hours) phases of the fungal interaction with epithelial cells, and respectively involve direct contact with the host cell or the action of soluble factors produced by mature fungal hyphae. Both early and late phases of epithelial damage have been shown to be subject to genetic regulation by the pH-responsive transcription factor PacC. This study sought to determine whether other transcriptional regulators play a role in modulating epithelial damage. In particular, whether the early and late phases of epithelial damage are governed by same or distinct regulators. Furthermore, whether processes such as spore uptake and hyphal adhesion, that have previously been documented to promote epithelial damage, are governed by the same cohorts of epithelial regulators. Using 479 strains from the recently constructed library of A. fumigatus transcription factor null mutants, two high-throughput screens assessing epithelial cell detachment and epithelial cell lysis were conducted. A total of 17 transcription factor mutants were found to exhibit reproducible deficits in epithelial damage causation. Of these, 10 mutants were defective in causing early phase damage via epithelial detachment and 8 mutants were defective in causing late phase damage via epithelial lysis. Remarkably only one transcription factor, PacC, was required for causation of both phases of epithelial damage. The 17 mutants exhibited varied and often unique phenotypic profiles with respect to fitness, epithelial adhesion, cell wall defects, and rates of spore uptake by epithelial cells. Strikingly, 9 out of 10 mutants deficient in causing early phase damage also exhibited reduced rates of hyphal extension, and culture supernatants of 7 out of 8 mutants deficient in late phase damage were significantly less cytotoxic. Our study delivers the first high-level overview of A. fumigatus regulatory genes governing lung epithelial damage, suggesting highly coordinated genetic orchestration of host-damaging activities that govern epithelial damage in both space and time.
The association between a body shape index and elevated urinary albumin–creatinine ratio in Chinese community adults
Authors: Zhang Yue , Gao Wenxing , Li Binqi , Liu Yang , Chen Kang , Wang Anping , Tang Xulei , Yan Li , Luo Zuojie , Qin Guijun , Chen Lulu , Wan Qin , Gao Zhengnan , Wang Weiqing , Ning Guang , Mu Yiming 
Published: July 2022

BackgroundObesity, especially visceral obesity, seems to be one of the most decisive risk factors for chronic kidney disease. A Body Shape Index (ABSI) is an emerging body size measurement marker of visceral obesity. This study aimed to explore whether ABSI is associated with albuminuria in Chinese community adults.MethodsThis cross-sectional study enrolled 40,726 participants aged 40 or older from seven provinces across China through a cluster random sampling method. ABSI was calculated by body mass index, waist circumference, and height. Increased albuminuria was defined as urinary albumin–creatinine ratio (UACR) ≥ 30 mg/g, indicating kidney injury. For ABSI, we divided it by quartile cutoff points and tried to determine the association between ABSI levels and UACR by multiple regression analysis. DAG (Directed Acyclic Graph) was plotted using literature and expert consensus to identify potential confounding factors.ResultsThe average age of subjects with elevated UACR was 61.43 ± 10.07, and 26% were men. The average age of subjects with normal UACR was 57.70 ± 9.02, and 30.5% were men. Multiple logistic regression analysis was conducted and demonstrated that the ABSI quartiles were related to elevated UACR positively (OR [95% CI] Q2 vs. Q1: 1.094 [1.004, 1.197]; OR [95% CI] Q3 vs. Q1: 1.126 [1.030, 1.231]; OR [95% CI] Q4 vs. Q1: 1.183 [1.080, 1.295], p for trend &lt; 0.001) after adjustments for confounding factors. The stratified analysis further showed that with the mounting for ABSI levels, elevated UACR more easily occurred in the people characterized by the elderly, men, and hypertension.ConclusionsIn Chinese community adults, people with higher ABSI levels can be deemed as high-risk individuals with UACR elevation, and it will be beneficial for them to lose weight and significantly reduce visceral fat.
Mass spectrometry imaging identifies altered hepatic lipid signatures during experimental Leishmania donovani infection
Authors: Tans Roel , Dey Shoumit , Dey Nidhi Sharma , Cao Jian-Hua , Paul Prasanjit S. , Calder Grant , O’Toole Peter , Kaye Paul M. , Heeren Ron M. A. 
Published: July 2022

IntroductionSpatial analysis of lipids in inflammatory microenvironments is key to understand the pathogenesis of infectious disease. Granulomatous inflammation is a hallmark of leishmaniasis and changes in host and parasite lipid metabolism have been observed at the bulk tissue level in various infection models. Here, mass spectrometry imaging (MSI) is applied to spatially map hepatic lipid composition following infection with Leishmania donovani, an experimental mouse model of visceral leishmaniasis.MethodsLivers from naïve and L. donovani-infected C57BL/6 mice were harvested at 14- and 20-days post-infection (n=5 per time point). 12 µm transverse sections were cut and covered with norhamane, prior to lipid analysis using MALDI-MSI. MALDI-MSI was performed in negative mode on a Rapiflex (Bruker Daltonics) at 5 and 50 µm spatial resolution and data-dependent analysis (DDA) on an Orbitrap-Elite (Thermo-Scientific) at 50 µm spatial resolution for structural identification analysis of lipids.ResultsAberrant lipid abundances were observed in a heterogeneous distribution across infected mouse livers compared to naïve mouse liver. Distinctive localized correlated lipid masses were found in granulomas and surrounding parenchymal tissue. Structural identification revealed 40 different lipids common to naïve and d14/d20 infected mouse livers, whereas 15 identified lipids were only detected in infected mouse livers. For pathology-guided MSI imaging, we deduced lipids from manually annotated granulomatous and parenchyma regions of interests (ROIs), identifying 34 lipids that showed significantly different intensities between parenchyma and granulomas across all infected livers.DiscussionOur results identify specific lipids that spatially correlate to the major histopathological feature of Leishmania donovani infection in the liver, viz. hepatic granulomas. In addition, we identified a three-fold increase in the number of unique phosphatidylglycerols (PGs) in infected liver tissue and provide direct evidence that arachidonic acid-containing phospholipids are localized with hepatic granulomas. These phospholipids may serve as important precursors for downstream oxylipin generation with consequences for the regulation of the inflammatory cascade. This study provides the first description of the use of MSI to define spatial-temporal lipid changes at local sites of infection induced by Leishmania donovani in mice.
nCD64 index as a novel inflammatory indicator for the early prediction of prognosis in infectious and non-infectious inflammatory diseases: An observational study of febrile patients
Authors: Liu Qianqian , Gao Yan , Yang Tao , Zhou Zhe , Lin Ke , Zhang Wei , Li Ting , Lu Yi , Shao Lingyun , Zhang Wenhong 
Published: July 2022

BackgroundGenerally, febrile patients admitted to the Department of Infectious Diseases, Fudan University Affiliated Huashan Hospital, China may eventually be diagnosed as infectious (ID) or non-infectious inflammatory diseases (NIID). Furthermore, mortality from sepsis remains incredibly high. Thus, early diagnosis and prognosis evaluation of sepsis is necessary. Here, we investigated neutrophil (n)CD64 index profile in a cohort of febrile patients and explored its diagnostic and prognostic value in ID and NIID.MethodsThis observational cohort study enrolled 348 febrile patients from the Emergency Department and Department of Infectious Diseases. nCD64 index were detected using flow cytometry, and dynamically measured at different timepoints during follow-up. Procalcitonin (PCT), C-reactive protein (CRP), and ferritin levels were measured routinely. Finally, the diagnostic and prognostic value of nCD64 index were evaluated by receiver operating characteristic (ROC) analysis and Kaplan-Meier curve analysis.ResultsOf included 348 febrile patients, 238, 81, and 29 were categorized into ID, NIID, and lymphoma groups, respectively. In ID patients, both SOFA score and infection site had impact on nCD64 index expression. In NIID patients, adult-onset Still’s disease patients had the highest nCD64 index value, however, nCD64 index couldn’t distinguish between ID and NIID. Regardless of the site of infection, nCD64 index was significantly higher in bacterial and viral infections than in fungal infections, but it could not discriminate between bacterial and viral infections. In bloodstream infections, gram-negative (G-) bacterial infections showed an obvious increase in nCD64 index compared to that of gram-positive (G+) bacterial infections. nCD64 index has the potential to be a biomarker for distinguishing between DNA and RNA virus infections. The routine measurement of nCD64 index can facilitate septic shock diagnosis and predict 28-day hospital mortality in patients with sepsis. Serial monitoring of nCD64 index in patients with sepsis is helpful for evaluating prognosis and treatment efficacy. Notably, nCD64 index is more sensitive to predict disease progression and monitor glucocorticoid treatment in patients with NIID.ConclusionsnCD64 index can be used to predict 28-day hospital mortality in patients with sepsis and to evaluate the prognosis. Serial determinations of nCD64 index can be used to predict and monitor disease progression in patients with NIID.