bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Technology Acceptance of Video Consultations for Type 2 Diabetes Care in General Practice: Cross-sectional Survey of Danish General Practitioners
Authors: Torp Daniel Cæsar , Sandbæk Annelli , Prætorius Thim 
Published: July 2022

Background
During the COVID-19 pandemic, video consultations became a common method of delivering care in general practice. To date, research has mostly studied acute or subacute care, thereby leaving a knowledge gap regarding the potential of using video consultations to manage chronic diseases.

Objective
This study aimed to examine general practitioners’ technology acceptance of video consultations for the purpose of managing type 2 diabetes in general practice.

Methods
A web-based survey based on the technology acceptance model measuring 4 dimensions—perceived usefulness, perceived ease of use, attitude, and behavioral intention to use—was sent to all general practices (N=1678) in Denmark to elicit user perspectives. The data were analyzed using structural equation modeling.

Results
The survey sample comprised 425 general practitioners who were representative of the population. Structural equation modeling showed that 4 of the 5 hypotheses in the final research model were statistically significant (P<.001). Perceived ease of use had a positive influence on perceived usefulness and attitude. Attitude was positively influenced by perceived usefulness. Attitude had a positive influence on behavioral intention to use, although perceived usefulness did not. Goodness-of-fit indices showed acceptable fits for the structural equation modeling estimation.

Conclusions
Perceived usefulness was the primary driver of general practitioners’ positive attitude toward video consultations for type 2 diabetes care. The study suggests that to improve attitude and technology use, decision-makers should focus on improving usefulness, that is, how it can improve treatment and make it more effective and easier.
Store-and-Forward Images in Teledermatology: Narrative Literature Review
Authors: Jiang Simon W , Flynn Michael Seth , Kwock Jeffery T , Nicholas Matilda W 
Published: July 2022

Background
Store-and-forward (SAF) teledermatology uses electronically stored information, including patient photographs and demographic information, for clinical decision-making asynchronous to the patient encounter. The integration of SAF teledermatology into clinical practice has been increasing in recent years, especially during the COVID-19 pandemic. Despite this growth, data regarding the outcomes of SAF teledermatology are limited. A key distinction among current literature involves comparing the quality and utility of images obtained by patients and trained clinicians, as these metrics may vary by the clinical expertise of the photographer.

Objective
This narrative literature review aimed to characterize the outcomes of SAF teledermatology through the lens of patient- versus clinician-initiated photography and highlight important future directions for and challenges of the field.

Methods
A literature search of peer-reviewed research was performed between February and April 2021. Key search terms included patient-initiated, patient-submitted, clinician-initiated, clinician-submitted, store-and-forward, asynchronous, remote, image, photograph, and teledermatology. Only studies published after 2001 in English were included. In total, 47 studies were identified from the PubMed electronic database and Google Scholar after omitting duplicate articles.

Results
Image quality and diagnostic concordance are generally lower and more variable with patient-submitted images, which may impact their decision-making utility. SAF teledermatology can improve the efficiency of and access to care when photographs are taken by either clinicians or patients. The clinical outcomes of clinician-submitted images are comparable to those of in-person visits in the few studies that have investigated these outcomes. Coinciding with the onset of the COVID-19 pandemic, asynchronous teledermatology helped minimize unnecessary in-person visits in the outpatient setting, as many uncomplicated conditions could be adequately managed remotely via images captured by patients and referring clinicians. For the inpatient setting, SAF teledermatology minimized unnecessary contact during dermatology consultations, although current studies are limited by the heterogeneity of their outcomes.

Conclusions
In general, photographs taken by trained clinicians are higher quality and have better and more relevant diagnostic and clinical outcomes. SAF teledermatology helped clinicians avoid unnecessary physical contact with patients in the outpatient and inpatient settings during the COVID-19 pandemic. Asynchronous teledermatology will likely play a greater role in the future as SAF images become integrated into synchronous teledermatology workflows. However, the obstacles summarized in this review should be addressed before its widespread implementation into clinical practice.
Age and the Course of GFR in Persons Aged 70 and Above
Authors: Schaeffner Elke S. , Ebert Natalie , Kuhlmann Martin K. , Martus Peter , Mielke Nina , Schneider Alice , van der Giet Markus , Huscher Dörte 
Published: July 2022

Background and objectives
In older adults, data on the age-related course of GFR are scarce, which might lead to misjudgment of the clinical relevance of reduced GFR in old age.

Design, setting, participants, & measurements
To describe the course of eGFR in older adults and derive reference values in population-based individuals, we used the longitudinal design of the Berlin Initiative Study (BIS) with a repeated estimation of GFR over a median of 6.1 years of follow-up. In 2069 community-dwelling older individuals (mean inclusion age 80 years, range 70–99), GFR was estimated biennially with the BIS-2 equation, including standardized creatinine and cystatin C levels, sex, and age. We described the crude and adjusted course using a mixed-effects model and analyzed the influence of death on the GFR course applying joint models. GFR slopes were compared using GFR equations on the basis of creatinine and/or cystatin C.

Results
We observed a decreasing, thus nonlinear, eGFR decline with increasing age in a population of old adults. The estimated 1-year slope for ages 75 and 90 diminished for men from −1.67 to −0.99 and for women from −1.52 to −0.97. The modeled mean eGFR for men aged ≥79 and women ≥78 was below 60 ml/min per 1.73 m2. Multivariable adjustment attenuated slopes only minimally. Taking death into account by applying joint models did not alter the nonlinear eGFR decline. Using eGFR equations on the basis of creatinine only showed linear slope patterns in contrast to nonlinear patterns for equations including cystatin C.

Conclusions
The eGFR decline depended on sex and age and changed only marginally after multivariable adjustment but decelerated with increasing age. Equations including cystatin C demonstrated a nonlinear slope challenging the previously assumed linearity of the decline of eGFR in old age.
Unveiling the biological interface of protein complexes by mass spectrometry-coupled methods
Authors: Shin Goeun , Lim Sung In 
Published: July 2022

Most biomolecules become functional and bioactive by forming protein
complexes through interaction with ligands that are diverse in size,
shape, and physicochemical properties. In the complex biological milieu,
the interaction is ligand-specific, driven by molecular sensing and
recognition of a binding interface localized within a protein structure.
Mapping interfaces of protein complexes is a highly sought area of
research as it delivers fundamental insights into proteomes and
pathology and hence strategies for therapeutics. While X-ray
crystallography and electron microscopy still serve as a gold standard
for structural elucidation of protein complexes, artificial and static
analytic nature thereof often results in a non-native interface that
otherwise might be negligible or non-existent in biological environment.
In recent years, the mass spectrometry-coupled approaches, chemical
crosslinking (CLMS) and hydrogen-deuterium exchange (HDMS), have become
valuable analytic complements to traditional techniques. These methods
explicitly identify hot residues and motifs embedded in binding
interfaces, in particular, for which the interaction is predominantly
dynamic, transient, and/or caused by an intrinsically disordered
domain. Here we review the principal role of CLMS and HDMS in protein
structural biology with a particular emphasis on the contribution of
recent examples to exploring biological interfaces. In addition, we
describe recent studies that utilized these methods to expand our
understanding of protein complex formation and related biological
processes and to increase probability of structure-based drug design.
Surgical Aid to Patients with Hepatopancreatobiliary Situations in Precovid Period and under Persistent Relapse of New Coronavirus Infection SARS-CoV-2
Authors: Nartaylakov M. A. , Panteleev V. S. , Salimgareev I. Z. , Loginov M. O. , Zolotukhin K. N. , Dorofeev V. D. , Mirasova G. Kh. , Shakurov D. F. , Petrov A. S. 
Published: July 2022

Introduction. The third wave of the new coronavirus infection (COVID-19) pandemic warrants total mobilisation of healthcare and social resources. In this respect, a pressing issue remains the provision of routine and emergency surgical care in patients with hepatopancreatobiliary diseases.Materials and methods. A retrospective analysis of the surgical outcomes in 5,040 hepatopancreatobiliary patients was carried out; this accounted for 51.1 % of the total abdominal surgeries.Results and discussion. Biliary lithiasis and its complications — choledocholithiasis with obstructive jaundice and residual choledocholithiasis — (54.4 %) as well as acute calculous cholecystitis (18.7 %) were operated most frequently. A sharp decrease over all hepatopancreatobiliary nosologies was registered for the surgical interventions in first pandemic year 2020. Thus, the median annual number of operations for biliary lithiasis and its complications was 550 (482–592 year-range) in the precovid period, while dropping to only 321 at the onset of pandemic (p <0.05). A first sixmonth survey of year 2021 revealed a growth of surgical activity for all hepatopancreatobiliary nosologies.Conclusion. Hepatopancreatobiliary operations prevail (54.4 % cases) in the total structure of level 3 abdominal surgical interventions. A high annual rate of surgical operations over nearly all hepatopancreatobiliary nosologies was interrupted in the first year of the new coronavirus infection outbreak. Meanwhile, the first half of 2021 showed a clear tend towards restoring the precovid statistical indicators, despite the stressful conditions of persistently relapsing COVID-19 that surgical facilities had faced.
Design of measuring flow velocity device for liquid fluid with venturi meter principles based on Arduino
Authors: Perdana Rendi Hadi , Wibowo Nur Aji , Ayub Made R. S. S. N. 
Published: July 2022

Fluid flow velocity in physics can be found on the principle of venturi meter. The Fluid flow concept is easy to understand if visualized. We need a learning media of fluid velocity, so the concept can understanding. Design of this tool aims to help students understand the fluid flow velocity. Data is taken automatically by Arduino-based water flow sensor, with speed change at the speed knop. Based on the design result of the tool which can be obtained by measuring the fluid flow velocity at a speed greater than 0.36 m/s, and proved by graph analysis logarithmic between velocity values of magnitude theory (Vtheory = 0.5x + 0.7934 m/s ) and tool speed (Vtool = 0.5825x + 1.129 m/s). The speed difference between the theory and the tool indicates the magnitude of the frictional speed due to the turbulent flow. So it can be concluded the design of this tool can be used as a learning media to help students in understanding the topic of fluid.
Extraction and characterization of algal oil from Lake Sebu, South Cotabato
Authors: Larida Alvin Q. , Bañaga Jaeven B. 
Published: July 2022

Algae is rich in storage lipids and fats that can be converted into biodiesel. This study determined the algal oil from Lake Sebu, South Cotabato as biodiesel source. Samples were prepared at varying treatments and ratio with n-Hexane. The algal oil was extracted and efficiency % were determined. FFA% and Acid Number of the oil extract were identified using chemical titration. FTIR was used for Chemical characterization while GC-MS identified fatty acid and other organics. With the constant volume of solvent and by changing the mass of dried algae, the percent yield of oil increases as the solvent to algae ratio increases. Therefore, biomass ratio with n-Hexane should be 1:3. The IR spectra of the oil extract indicated the presence of functional groups such as amine and carbonyl group of amides, methylene, methyl, and alkene. While, GC-MS showed that the fatty acids found can be a potential biodiesel.
Impact of transdermal flunixin administration on serum prostaglandin E2 and cortisol concentrations in piglets following castration
Authors: Merenda Victoria R. , Wagner Brooklyn K. , Arruda Andréia G. , Lopez Soriano Magdiél , Montgomery Shawnee , Coetzee Johann F. , Pairis-Garcia Monique D. 
Published: July 2022

Abstract

OBJECTIVE
To assess the effects of transdermal flunixin administration on serum prostaglandin E2 (PGE2) and cortisol concentrations in piglets undergoing castration.

ANIMALS
104 litters with at least 4 male piglets/litter.

PROCEDURES
Litters were randomly assigned to 1 of 4 treatments: transdermal flunixin (3.33 mg/kg) administration followed by surgical castration (CF; n = 28), transdermal flunixin administration followed by sham castration (SF; n = 26), application of physiologic saline solution followed by sham castration (S; n = 26), and application of physiologic saline solution followed by surgical castration (C; n = 24). Blood samples were collected 24 hours before and 1, 4, and 25 hours after castration or sham castration.

RESULTS
Serum PGE2 concentrations for piglets in the C and CF groups did not differ at any time. Piglets in the S group tended to have higher serum PGE2 concentrations 1 hour after sham castration compared with piglets in the SF group. One hour after the procedure, piglets that underwent castration had higher serum cortisol concentrations than did piglets that underwent sham castration. Piglets in the CF group had higher serum cortisol concentrations than did piglets in the SF group 4 hours after the procedure, but serum cortisol concentrations did not differ between the C and S groups.

CLINICAL RELEVANCE
Further studies are needed to explore dosing regimens, including effective doses and administration frequencies, and the pharmacokinetics of flunixin following transdermal administration in piglets undergoing castration.
Case Study – A Comparative Analysis of Two Scenarios of a RC Frame Structural System for a Duplex House
Authors: Țăranu George 
Published: July 2022

Abstract
The paper presents the comparative analyses in terms of dynamic behavior of two scenarios of an RC frame structural system for a duplex house situated in Neamt, Romania a seismic zone with PGA 0.25g. The study shows the structural behavior in terms of vibration modes, horizontal displacements and efforts. The conclusions offer the best argument to chose the preferred structural system by owner.
Bio-Cementation: An Eco-Friendly Solution to Reduce the Water Infiltrations in Hidrotechnical Concrete Elements
Authors: Cătălin Sbîrlea , Nicolina Isopescu Dorina , Dragoş Ungureanu , George Maxineasa Sebastian , Răzvan-Andrei Polcovnicu 
Published: July 2022

Abstract
The bio-cementation repairing technique consists in using a bio product which precipitates in a porous environment and thus, filling the internal voids. In the construction industry, there is a series of applications for this repairing technology, mainly for cementitious materials. In this respect, the calcium carbonate-based materials are considered to be the most suitable bio products since they are compatible with a wide range of concrete mixes.
This paper presents a method of manufacturing a calcium carbonate bio product, using a device designed and manufactured exclusively for this experimental work. In order to design a bio product with an unique set of properties, various preliminary samples, obtained by varying the material quantities, the preparation time and working temperatures, have been tested. The bio product analyzed in this work may increase the impermeability of mortar and concrete elements, by continuous sealing of microcracks that can occur throughout the life cycle of the members. Thus, since this bio product was meant to be a component of the mortar/concrete mixture, the mechanical properties were determined by testing several mortar samples made with different cement-bio product ratios.
On the Seismic Resilience of Interwar Buildings
Authors: Gruia Liviu-Costin 
Published: July 2022

Abstract
This paper deals with multi-story buildings erected mostly in interwar period in seismic areas and designed for gravitational actions only. The typical structural system is reinforced concrete frames and masonry infills. A usual multi-story interwar structure was chosen in order to evaluate its seismic resilience. There were made in situ measurements for its dynamic characteristics. The numerical model was calibrated according to in situ measurements. There were proposed two methods of increasing the seismic resilience. First method consists in improving the resilience by reshaping without reinforcing. The second method is additional to the first. It consists in reinforcing infilled frames in order to take over seismic loads.
Sinonasal malignant melanoma
Authors: Birta Daiana , Blaj Simona , Terteci-Popescu Dragos , Avram Emil , Tiple Cristina , Chirila Magdalena , Ungureanu Andrei , Zahu Renata 
Published: July 2022

Abstract
Sinonasal malignant melanoma is a rare, aggressive tumor, associated with a poor prognosis, accounting for 8-15% of all head and neck melanomas and 0.5-2% of all melanomas. The diagnosis is given by histopathological and immunological examination. Elective treatment consists of surgical excision with free resection borders, and adjuvant chemotherapy / radiotherapy / immunotherapy / checkpoint inhibitors can be used to control local recurrence and distant metastases. We chose to present the case of an unresectable ethmoidal malignant melanoma at the time of diagnosis, pembrolizumab treatment converting it to resectability, with improving patient’s quality of life, even if the patient developed an adrenal metastasis.
Extramedullary plasmacytoma of the nasal cavity with kappa light chains in a young person: A case report
Authors: Hammoud Zakaria Chekh , Benmansour Najib , Ouahidi Youness , Maqboub Omar , Elamine Mohamed Nour-dine Elalami 
Published: July 2022

Abstract

BACKGROUND. Extramedullary plasmacytoma is a rare tumor, representing less than 1% of head and neck tumors. This specific type of tumor occurs in 90% of cases in the upper aero-digestive tract, with more frequent location in 80% of cases in the submucosa.

CASE REPORT. We report the case of a 39-year-old young man who presented for bilateral nasal obstruction with swelling of the left nasal region and intermittent epistaxis of moderate abundance. The clinical examination revealed a tumor mass in the nasal cavity bleeding on contact, with the absence of nasal airflow. The cranio-facial CT and MRI imaging with contrast agent showed a large, locally advanced tumor in the left nasal cavity, with destruction of the surrounding osteo-cartilaginous structures. The anatomopathological study of the biopsy specimen returned in favour of a plasmacytoma of the nasal cavity with kappa light chains. The biological assessment of the multiple myeloma confirmed that it was an extramedullary plasmacytoma. Radiotherapy treatment was proposed.

CONCLUSION. In the light of this case of extramedullary plasmacytoma, we will discuss the clinical, therapeutic and evolutionary characteristics of this tumour.
Antibacterial Activity of Clove, Oregano, Thyme, Eucalyptus, and Tea Tree Essential Oils against Escherichia coli and Klebsiella pneumoniae strains
Authors: Băicuș Anda , Mattuzzi Flavio Cesare , Paraschiv Ana Maria , Dinu Rares-Sebastian , Dumitrescu Maria Carina , Marinescu Andrei Alexandru , Ionescu Dorin , Dragos Dorin 
Published: July 2022

Abstract

Background: In view of the high recurrence rate of urinary tract infections and the increasing number of germs resistant to multiple antibiotics, the aim of the present study was to evaluate the antibacterial properties of clove, oregano, thyme, eucalyptus, tea tree essential oils (EOs) against 32 isolates of Escherichia coli and 28 isolates of Klebsiella pneumoniae from patients with urinary tract infections (UTI).

Methods: The agar disk diffusion method was used to assess the susceptibility of these isolates to essential oils and the minimal inhibitory concentration (MIC), and the minimal bactericidal concentration (MBC) were determined.

Results: Our results suggest that volatile phenols (such as carvacrol in oregano EO, thymol in thyme EO, and eugenol in clove EO) are more efficacious as antibacterial than non-aromatic compounds (such as eucalyptol in eucalyptus EO and terpinene derivatives in tea tree EO).

Conclusion : The oregano EO, followed by thyme appear to have the highest efficacy against Escherichia coli and Klebsiella pneumoniae isolates investigated.
Novel DCX pathogenic variant in a girl with subcortical band heterotopia
Authors: Papuc Sorina Mihaela , Budisteanu Magdalena , Erbescu Alina , Ionescu Virgil , Iliescu Catrinel , Sandu Carmen , Arghir Aurora 
Published: July 2022

Abstract
Subcortical band heterotopia (SBH), is a brain malformation defined by symmetrical and bilateral heterotopic gray matter bands localized deep within the white matter, between the cortex and lateral ventricles. SBH is the result of abnormal neuronal migration, with improper positioning of the cortical neurons. DCX gene (doublecortin), a microtubule-associated protein with essential roles in neuronal migration and differentiation during brain development, is one of the main contributors to the X-linked Lissencephaly spectrum pathogenesis (OMIM #300067). DCX variants are responsible for SBH in females and isolated lissencephaly in males. Herein, we present a 7-year-old girl with a de novo frameshift variant in DCX gene, unreported by date. The patient has focal complex seizures with onset at 23 months of age, fully controlled with medication, mild tremor and coordination impairment of fine movements and some learning difficulties, otherwise with normal development. The brain magnetic resonance imaging revealed the presence of thick SBH. Direct sequencing of DCX gene revealed a pathogenic heterozygous cytosine duplication in exon 3; this frameshift variant leads to a premature stop codon in position 164 (p.Gln160Profs*5). The variant type and its predicted consequence at protein level correlates with the severity of radiological findings. The clinical presentation of our patient is, however, milder than expected. Our research expands the mutational spectrum of DCX gene in SBH females and provides a detailed clinical and imagistic description of the patient. This paper highlights the utility of single gene sequencing as a first-tier diagnostic test of patients with gene-specific phenotypic features.