bluuebunny/crossref_metadata_2025_split huggingface dataset:
Connection assist devices for peritoneal dialysis
Authors: Chan Anthony T. P. , Tang Sydney C. W. 
Published: September 2022

AbstractPatients with kidney failure who require kidney replacement therapy (KRT) have been increasing globally. Home‐based therapies, such as peritoneal dialysis (PD), allow patients to undergo KRT in the home environment, alleviating treatment costs, patient transport, and hospital admission. Peritoneal dialysis‐related peritonitis is still the most frequent complication of PD and is often related to technique failure, which can result in PD failure, transfer to hemodialysis, or mortality. The cause of technique failure is multifactorial, and a portion of technique failure is due to underlying physical or cognitive disabilities. There are several connection devices that have been developed to reduce CAPD‐related peritonitis. These connection devices are reviewed in this article.
West Nile virus transfusion‐transmission risk in Australia associated with a seasonal outbreak in the United States
Authors: Kiely Philip , Seed Clive R. , Gambhir Manoj , Cheng Allen C. , McQuilten Zoe K. , Wood Erica M. 
Published: September 2022

AbstractBackgroundWest Nile virus (WNV) is a potentially transfusion‐transmissible virus endemic in the US. The aim of this study was to estimate the monthly WNV transfusion transmission (TT) risk in Australia associated with donors returning from the US in 2018 and consider the implications for mitigation strategies.Study Design and MethodsWe used a probabilistic risk model to estimate the monthly WNV TT risks for each outbreak state/district in the US for the 2018 transmission season and the cumulative monthly risk for all US states/districts.ResultsThe highest monthly cumulative transfusion risk in Australia occurred in August 2018 when 746 West Nile neuroinvasive disease cases were reported in the US and the estimated mean WNV TT risk in Australia was 1 in 1.0 × 108 donations (95% confidence interval [CI]: 1.6 × 108–7.0 × 107). The highest risk during August was associated with California, with a mean risk of 1 in 4.1 × 108 donations (95% CI: 2.9 × 108–6.6 × 108), representing 24% of the total risk in Australia. The cumulative TT risk in Australia for the other 11 months varied from 1 in 1.5 × 108 donations (95% CI: 2.3 × 108–1.0 × 108) in September to 1 in 3.9 × 1010 donations (95% CI: 6.1 × 1010–2.7 × 1010) in February.DiscussionOur modeling indicates that the WNV TT risk in Australia associated with seasonal outbreaks in the US is extremely small and may not warrant donation restrictions for donors returning from the US.
International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Basel and three virtual business meetings: Update on blood group systems
Authors: Gassner Christoph , Castilho Lilian , Chen Qing , Clausen Frederik Banch , Denomme Gregory A. , Flegel Willy A. , Gleadall Nick , Hellberg Åsa , Ji Yanli , Keller Margaret A. , Lane William J. , Ligthart Peter , Lomas‐Francis Christine , Nogues Nuria , Olsson Martin L. , Peyrard Thierry , Storry Jill R. , Tani Yoshihiko , Thornton Nicole , van der Schoot Ellen , Veldhuisen Barbera , Wagner Franz , Weinstock Christof , Wendel Silvano , Westhoff Connie , Yahalom Vered , Hyland Catherine A. 
Published: September 2022

AbstractBackground and ObjectivesUnder the ISBT, the Working Party (WP) for Red Cell Immunogenetics and Blood Group Terminology is charged with ratifying blood group systems, antigens and alleles. This report presents the outcomes from four WP business meetings, one located in Basel in 2019 and three held as virtual meetings during the COVID‐19 pandemic in 2020 and 2021.Materials and MethodsAs in previous meetings, matters pertaining to blood group antigen nomenclature were discussed. New blood group systems and antigens were approved and named according to the serologic, genetic, biochemical and cell biological evidence presented.ResultsSeven new blood group systems, KANNO (defined numerically as ISBT 037), SID (038), CTL2 (039), PEL (040), MAM (041), EMM (042) and ABCC1 (043) were ratified. Two (039 and 043) were de novo discoveries, and the remainder comprised reported antigens where the causal genes were previously unknown. A further 15 blood group antigens were added to the existing blood group systems: MNS (002), RH (004), LU (005), DI (010), SC (013), GE (020), KN (022), JMH (026) and RHAG (030).ConclusionThe ISBT now recognizes 378 antigens, of which 345 are clustered within 43 blood group systems while 33 still have an unknown genetic basis. The ongoing discovery of new blood group systems and antigens underscores the diverse and complex biology of the red cell membrane. The WP continues to update the blood group antigen tables and the allele nomenclature tables. These can be found on the ISBT website (http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology/).
Co‐activation of GPCRs facilitate GIRK‐dependent current
Authors: Condon Alec F. , Asad Naeem , Dore Timothy M. , Williams John T. 
Published: September 2022

AbstractThe activity of dopamine neurons is dependent on both intrinsic properties and afferent projections. One potent form of inhibition is mediated by the activation of two inhibitory G protein‐coupled receptors, D2 and GABAB receptors. Each of these receptors activates G protein‐coupled inwardly rectifying potassium (GIRK) channels. Recordings in brain slices have shown that co‐activation using saturating concentrations of agonists results in occlusion of the GIRK current. The present study examined the interaction between D2 and GABAB receptors using transient applications of sub‐saturating concentrations of agonists where the co‐application of one agonist resulted in both facilitation and inhibition (desensitization) of the other. The heterologous facilitation was modelled based on the known cooperative interaction between the G protein βγ subunits and GIRK channels. The results indicate that a low tonic level of G βγ results in facilitation of GIRK current and a high level of G βγ results in occlusion. The kinetics of the current induced by transient receptor activation is prolonged in each case. The results suggest that the cooperative interaction between G βγ subunits and GIRK channels determines both the amplitude and kinetics of GPCR‐dependent current.
imageKey points
Inhibitory D2 and GABAB receptors modulate dopamine neuron activity through shared G protein‐coupled inwardly rectifying potassium (GIRK) channels.
This study reports robust bidirectional interactions between these two converging receptor pathways.
Coincident activation of D2 and GABAB receptors leads to facilitation of GIRK channel currents, augmenting both amplitude and prolonging the duration of phasic responses.
Activation of either D2 or GABAB receptors also acutely desensitized the GIRK channel current induced by D2 receptor activation that rapidly recovers following termination of desensitizing stimulus.
Results demonstrate that the activity of either G protein‐coupled receptor system must be considered in the context of other G protein‐coupled receptors.
Stall Margin Improvement in a Transonic Compressor With a Casing Treatment: Flow Mechanism
Authors: Hah Chunill 
Published: September 2022

Abstract
A compressor casing treatment with circumferential casing grooves (CCGs) is studied in detail. The primary objective of the current paper is to unearth the main driving fluid mechanism that changes the stall margin in a transonic compressor with CCGs. Large eddy simulation (LES) is applied to calculate the transonic compressor flow fields with and without CCGs. The present investigation shows that CCGs reduce the mass flow through the tip gap by about 16% near the stall condition. Calculated flow fields show that most of this reduction of tip leakage flow occurs near the CCGs. Reinjected flow from the CCGs pushes the tip leakage flow radially inward below the casing and changes how the tip leakage flow collides with the incoming main passage flow. However, a detailed examination of the calculated flow in the tip region shows that the reinjected flow does not contribute to the reduction of the overall blockage generation. The primary driver for reducing blockage generation with CCGs is the reduction of overall mass flowrate through the tip gap. In the present investigation, measurements show a very small decrease in efficiency with CCGs at the design flow condition, although the difference in efficiency is within the measurement uncertainty. Results from the LES simulation at the design condition with CCGs show that the tip leakage vortex (TLV) is pulled toward the blade suction side and double leakage flow is eliminated. The result is that the simulated efficiencies with and without CCGs are almost the same.
Association of mean arterial pressure with 5-year risk of incident diabetes in Chinese adults：a secondary population-based cohort study
Authors: Wu Yang , Hu Haofei , Cai Jinlin , Chen Runtian , Zuo Xin , Cheng Heng , Yan Dewen 
Published: September 2022

ObjectiveHypertension predicts the development of diabetes. However, there are still lacking high-quality studies on the correlation between mean arterial pressure (MAP) and incident diabetes. We aimed to explore the relationship between MAP and diabetes in Chinese adults.DesignThis is a secondary retrospective cohort study and the data were downloaded from the ‘DATADRYAD’ database (www.Datadryad.org).ParticipantsThe study included 210 418 adults without diabetes at baseline between 2010 and 2016 across 32 sites and 11 cities in China.SettingThe target-independent and dependent variables were MAP measured at baseline and diabetes occurred during follow-up. Cox proportional hazards regression was used to explore the relationship between MAP and diabetes.Primary outcome measuresThe outcome was incident diabetes, which was defined as fasting blood glucose ≥7.00 mmol/L and/or self-reported diabetes during follow-up. Patients were censored either at the time of the diagnosis or at the last visit, whichever comes first.Results3927 participants developed diabetes during a 5-year follow-up. After adjusting covariates, MAP positively correlated with diabetes (HR=1.008, 95% CI 1.005 to 1.011, p<0.001), and the absolute risk difference was 0.02%. E-value analysis and multiple imputations were used to explore the robustness of the results. The relationship between MAP and diabetes was also non-linear, and the inflection point of MAP was 100.333 mm Hg. Subgroup analysis revealed a stronger association between MAP and diabetes in people with age (≥30,<50 years old), fasting plasma glucose <6.1 mmol/L and drinking. Additionally, receiver operating characteristic (ROC) curves showed the predictive performance of MAP for diabetes was similar to systolic blood pressure (SBP) (area under the curve (AUC)=0.694 with MAP vs AUC=0.698 with SBP).ConclusionsMAP is an independent predictor for a 5-year risk of incident diabetes among Chinese adults. The relationship between MAP and diabetes is also non-linear. When MAP is below 100.333 mm Hg, MAP is closely positively related to diabetes.
How did communities in North West England respond to the COVID-19 lockdown? Findings from a diary study
Authors: Ward Fiona , Halliday Emma , Holt Vivien , Khan Koser , Sadler Gill , Wheeler Paula , Goldthorpe Joanna 
Published: September 2022

ObjectivesDuring the COVID-19 pandemic, the UK government and public health leaders advocated for community level responses to support vulnerable people. This activity could be planned and co-ordinated, however much was informal and developed organically. The effects on the individuals who were involved in providing and receiving informal support and implications for their communities have not been widely explored. The aim of this study was therefore to document and explore the nature, potential effects and longevity of community responses to the COVID-19 pandemic.ParticipantsWe asked 15 individuals in North West England to keep a diary during the first UK COVID-19 lockdown. Over 8 weeks, diaries were completed and supported with weekly calls with researchers. A community capacity building framework was used to explore reported community responses to the COVID-19 pandemic.ResultsDiarists described community characteristics that enabled and hindered helpful responses in the lockdown context. Diarists frequently described informal approaches with residents acting alone or with near neighbours, although there were examples of community networks and residents recommencing formal volunteering activities. Diarists reported communities providing practical help and social support to vulnerable people. Participants perceived a greater sense of community, increased contact between residents and new networks during the period covered.ConclusionThe diaries provided valuable insights and the framework was a useful tool to explore the COVID-19 lockdown context. The findings indicate that organic capacity building took place, primarily via individual agency, highlighting the risk of communities being ‘left behind’ if there were not individuals or community networks available with resources to plug gaps in organisational support. Recommendations to sustain helpful responses to the pandemic include further consideration of ongoing community mobilisation, empowerment and community control within the capacity building framework.
Study protocol to determine the effects of highly absorbable oral curcumin on the indicators of cognitive functioning: a double-blind randomised controlled trial
Authors: Komiyama Maki , Ozaki Yuka , Wada Hiromichi , Yamakage Hajime , Satoh-Asahara Noriko , Kishimoto Atsuhiro , Katsuura Yasuhiro , Imaizumi Atsushi , Hashimoto Tadashi , Sunagawa Yoichi , Morimoto Tatsuya , Hasegawa Koji 
Published: September 2022

IntroductionMild cognitive impairment (MCI) refers to a state in which cognitive functions, such as memory, have diminished but daily activities are largely unhampered. MCI is often overlooked but carries the risk of leading to development of dementia later. Curcumin is the main component of the natural herbal medicine turmeric. Curcumin is widely used as a health food and is an antioxidant that has anti-inflammatory and anti-amyloid actions. The current trial was designed to determine the effects of curcumin on indicators of cognitive functioning.Methods and analysisThe current trial will be a single-centre randomised placebo-controlled double-blind parallel group trial. The participants will be 60 members of the general public with potential MCI, based on dementia screening using the Japanese version of the Mini Mental State Examination (MMSE-J). The investigational health food used in this trial will be a recently developed preparation for highly absorbable oral curcumin. This trial will determine the effects of the highly absorbable oral curcumin (brand name: curcuRouge) on the indicators of cognitive functioning, including the scores obtained with the MMSE-J, which is an interview-based measure of cognitive functioning, and the blood biomarkers that have been reported to be associated with dementia.Ethics and disseminationInformed written consent will be obtained from all the participants. The Ethical Review Board of the National Hospital Organization Kyoto Medical Center approved the study protocol.Trial registration numberUniversity Hospital Medical Information Network (UMIN000042471).
Design, development and validation of Food Frequency Questionnaires for the diabetic population: protocol for a systematic review and meta-analysis
Authors: Fernández-Cao José C , Aparicio Estefania 
Published: September 2022

IntroductionThe Food Frequency Questionnaire is one of the most widely used tools for estimating nutritional intake in epidemiological studies. No study has been systematically performed to comprehensively explore Food Frequency Questionnaires designed, developed and validated specifically for the diabetic population (FFQs-DDV-DiaP). Therefore, a systematic review and meta-analysis will be carried out in order to identify and describe FFQs-DDV-DiaP; to examine their design, development, validity and reproducibility; as well as to estimate the overall degree of correlation and agreement; and to evaluate the factors that affect them.Methods and analysisA systematic literature review will be performed in PubMed/MEDLINE, Scopus and Web of Science to find potentially relevant studies. Original studies related to the design, development, as well as the assessment of the validity and reproducibility of FFQs-DDV-DiaP; reported in English or Romance languages will be selected. Independent reviewers will select studies, extract relevant data and assess FFQs-DDV-DiaP quality. Data will be pooled using the generic inverse-variance method with random-effects models and expressed as correlation coefficients or mean differences with 95% CIs to examine the global validity and reproducibility of FFQs-DDV-DiaP. Heterogeneity will be evaluated by the Cochran Q-statistic and quantified by the I2 statistic. Stratified analyses and random-effects meta-regressions will be performed to explore heterogeneity and whether any covariate influences the effect sizes. Finally, publication bias will be assessed through the Begg’s and Egger’s tests.Ethics and disseminationThis systematic review and meta-analysis will not use confidential personal data. Therefore, the requirement of ethical approval or informed consent is not necessary. The results of this review will be disseminated only in peer-reviewed publications or at relevant scientific conferences.PROSPERO registration numberCRD42021268575.
An ounce of prevention is worth a pound of cure—the arts as a vehicle for knowledge translation and exchange (KTE) in public health during a pandemic: a realist-informed developmental evaluation research protocol
Authors: Bergeron Dave A , Rey Lynda , Murillo Salazar Fernando , Michaud Anne Marie , Ccaniahuire Laura Felipe 
Published: September 2022

IntroductionThe COVID-19 crisis has led to the adoption of strict and coercive preventive measures. The implementation of these measures has generated negative impacts for many communities. The situation is especially worrisome for Indigenous communities in Peru. Therefore, it is necessary to recognise the contribution of the experiential knowledge of Indigenous communities and to implement innovative approaches. The use of art can be a promising avenue for working in partnership with Indigenous communities.The goal of this research is to (1) develop an intervention promoting barrier measures and vaccination to limit the transmission of COVID-19 among Indigenous communities using an arts-based and community-based knowledge translation and exchange (ACKTE) model; and (2) understand the contextual elements and mechanisms associated with the process of developing a preventive intervention using the ACKTE model.Methodology and analysisThis research will take place in Indigenous communities in Peru and will be based on a developmental evaluation guided by the principles of realist evaluation. Members of two Indigenous communities, local authorities, health professionals and artists will participate in the intervention development process as well as in the developmental evaluation. For data collection, we will conduct modified talking circles and semistructured individual interviews with stakeholders as well as an analysis of documents and artistic works produced.Ethics and dissemination of resultsThis research received the approval of theUniversité du Québec à Rimouski’s research ethics board. In addition to scientific articles, the results of this research will be disseminated through videos and during an artistic performance.
Association between physical activity and musculoskeletal pain: an analysis of international data from the ASAP survey
Authors: Rhim Hye Chang , Tenforde Adam , Mohr Lisa , Hollander Karsten , Vogt Lutz , Groneberg David A , Wilke Jan 
Published: September 2022

ObjectiveTo explore the association of physical activity (PA) with musculoskeletal pain (MSK pain).DesignCross-sectional studySetting14 countries (Argentina, Australia, Austria, Brazil, Chile, France, Germany, Italy, the Netherlands, Singapore, South Africa, Spain, Switzerland and the USA).ParticipantsIndividuals aged 18 or older.Primary and secondary outcome measuresPA volumes were assessed with an adapted version of the Nordic Physical Activity Questionnaire-short. Prevalence of MSK pain was captured by means of a 20-item checklist of body locations. Based on the WHO recommendation on PA, participants were classified as non-compliers (0–150 min/week), compliers (150–300 min/week), double compliers (300–450 min/week), triple compliers (450–600 min/week), quadruple compliers (600–750 min/week), quintuple compliers (750–900 min/week) and top compliers (more than 900 min/week). Multivariate logistic regression was used to obtain adjusted ORs of the association between PA and MSK pain for each body location, correcting for age, sex, employment status and depression risk.ResultsA total of 13 741 participants completed the survey. Compared with non-compliers, compliers had smaller odds of MSK pain in one location (thoracic pain, OR 0.77, 95% CI 0.64 to 0.93). Double compliance was associated with reduced pain occurrence in six locations (elbow, OR 0.70, 95% CI 0.50 to 0.98; forearm, OR 0.63, 95% CI 0.40 to 0.99; wrist, OR 0.74, 95% CI 0.57 to 0.98; hand, OR 0.57, 95% CI 0.40 to 0.79; fingers, OR 0.72, 95% CI 0.52 to 0.99; abdomen, OR 0.61, 95% CI 0.41 to 0.91). Triple to top compliance was also linked with lower odds of MSK pain (five locations in triple compliance, three in quadruple compliance, two in quintuple compliance, three in top compliance), but, at the same time, presented increased odds of MSK pain in some of the other locations.ConclusionA dose of 300–450 min WHO-equivalent PA/week was associated with lower odds of MSK pain in six body locations. On the other hand, excessive doses of PA were associated with higher odds of pain in certain body locations.