bluuebunny/crossref_metadata_2025_split huggingface dataset:
NBDHEX re‐sensitizes adriamycin‐resistant breast cancer by inhibiting glutathione S‐transferase pi
Authors: Sha Huanhuan , Zou Renrui , Lu Ya , Gan Yujie , Ma Rong , Feng Jifeng , Chen Dan 
Published: October 2022

AbstractPurposeAdriamycin is a novel chemotherapeutic agent of great benefit for treating breast cancer. However, adriamycin ‐resistance remains a major obstacle. The vital Glutathione transferase P1 (GSTPi) inhibitor 6‐(7‐nitro‐2,1,3‐benzoxadiazol‐4‐ylthio) hexanol (NBDHEX) has recently shown antitumor activity in various cancers. In this study, we analyzed the effect of NBDHEX and adriamycin combination against breast cancer in vitro and in vivo.MethodsCCK‐8 assay was performed to test cell viability. The location and expression level of GSTpi was determined by immunofluorescence and Western blot in cells and immunohistochemistry staining in tissues. The enzyme activity test was applied to detect the effect of NBDHEX on the activity of GSTpi. The apoptosis related proteins' expression was tested using Western blot. The phosphorylation sites of GSTpi were detected by mass spectrometry. Antitumor effects of single treatment or co‐administration of adriamycin and NBDHEX were evaluated in nude mice.ResultsNBDHEX treatment inhibited GSTpi enzyme activity and co‐administration of adriamycin and NBDHEX promoted apoptosis of adriamycin‐resistance breast cancer cell. Moreover, drug combination of NBDHEX and adriamycin significantly enhanced tumor growth inhibition compared with single agent.ConclusionNBDHEX serves as a good candidate for combination with adriamycin, offering new insights for breast cancer treatment.
Chemical and Bioactivity Diversity of 2‐(2‐Phenylethyl)chromones in Agarwood: A Review
Authors: Yu Meng , He Qing‐Qin , Chen Xi‐Qin , Feng Jian , Wie Jian‐He , Liu Yang‐Yang 
Published: October 2022

Abstract2‐(2‐Phenylethyl)chromone derivatives are regarded as key components in agarwood. An oxygen‐containing heterocycle with a benzoannelated γ‐pyrone moiety form the bioactive core of 2‐(2‐phenylethyl)chromones. With different substituents and positions, 2‐(2‐phenylethyl)chromone derivatives exhibit diverse biological properties, such as antioxidant, antimicrobial, neuroprotective, anti‐inflammatory, and acetylcholinesterase inhibitory activities. In this review, we summarized the studies (from January 1976 to September 2021) on phytochemistry, bioactivity and quality control of 2‐(2‐phenylethyl)chromones. These studies aimed to clarify the chemical specificity, diversity and structure‐activity relationship of 2‐(2‐phenylethyl)chromones. In addition, we assumed that diverse factors such as tree species, induction methods and formation time contribute to the chemical diversity of 2‐(2‐phenylethyl)chromones. Furthermore, this review contends that different types of 2‐(2‐phenylethyl)chromones should be utilized in the quality control methods of agarwood.
Detection of Cutibacterium acnes from multiple miliary osteoma cutis
Authors: Kondo Makoto , Yamanaka Keiichi 
Published: October 2022

AbstractThe patient had a history of acne vulgaris at a young age. The excisional biopsy from the nodule of the face showed the findings of multiple miliary osteoma cutis (MMOC). As Cutibacterium acnes were identified in calcified nodules, Cutibacterium acnes may be one of the triggering factors for MMOC. MMOC patients need proper skin care because the subcutaneous calcification is slowly formed even after middle age.
Two‐dimensional V2CTx In‐situ Derived Porous V2O3@C Flakes Towards Zinc‐Ion Capacitors as a Competitive Cathode Material
Authors: Chen Huaqing , Wang Yuyan , Liu Chanjuan , Hou Linrui , Sun Jinfeng , Yuan Changzhou 
Published: October 2022

AbstractZinc‐ion capacitors (ZICs) are promising electrochemical devices for energy storage due to their advantages including environmental friendliness, safety, and simple assembly. However, its application is still subject to modest rate and stable performance of the involved cathodes. In this work, we in‐situ fabricate a two‐dimensional flake‐shape framework containing amorphous carbon‐coated V2O3 nanowires (V2O3@C) by using few‐layered V2CTx (f‐V2CTx) as the raw material, and further utilize it as an appealing cathode material for ZICs. Thanks to the nanowires‐assembled porous architecture, conductive carbon coating, and rich defects through in‐situ lattice tunnel distortion of corundum‐type V2O3, the V2O3@C cathode delivers an excellent rate capability of ∼175 mAh g−1 at 8.0 A g−1, and the stable long‐term cycling behavior (∼168.0 mAh g−1 remained after 6500 cycle at 5.0 A g−1s). Furthermore, the V2O3@C based ZICs exhibit a specific energy density of ∼36.3 Wh kg−1 and a long‐term cycle life with a capacity retention value of 74.3% after 10,000 cycles at 1.0 A g−1. This highlights that our V2O3@C is a competitive cathode candidate for advanced ZICs.
Functional Human Serum Albumin as a Dual Phototherapeutic Nanoplatform for Triple‐negative Breast Cancer Therapy and Metastasis Inhibition
Authors: Li Sen , Tian Mengting , Cai Yanfei , Jin Jian , Yang Zhaoqi 
Published: October 2022

AbstractThe major obstacles to triple‐negative breast cancer (TNBC) therapy are metastasis and mortality rates, leading to the failure treatment of traditional chemotherapy. Therefore, low toxicity drugs and more effective therapeutic approaches are greatly desired. Considering the drawbacks of indocyanine green (ICG) and purpurin such as poor bioavailability and rapid blood clearance, an endogenous carrier material human serum albumin (HSA) was employed to construct the nanoplatform through hydrophobic interaction with the inspiration of successful delivery of paclitaxel. Herein, we developed and fabricated a new self‐assembled albumin‐based drug delivery system (ICG‐purpurin@HSA, HIP) with encapsulation of ICG and purpurin. Of note, compared to free ICG and purpurin, enhanced treatment efficiency was achieved by the HIP with the help of reactive oxygen species (ROS)‐heat‐induced damage and nutrient supply cutoff. Consequently, an efficient drug delivery platform based on photothermal therapy (PTT) and photodynamic therapy (PDT) was proposed, revealing a promising strategy for TNBC treatment.
A comprehensive review of castor oil‐derived renewable and sustainable industrial products
Authors: Singh Shikha , Sharma Sumit , Sarma Saurabh Jyoti , Brar Satinder Kaur 
Published: October 2022

AbstractCastor oil is one important raw material that could serve as a renewable feedstock for industries in the age of exhausting fossil fuels. The chemical composition of oil and the structure of hydroxyl fatty acid are responsible for its unique physicochemical properties. The oil has diverse applications from pharmaceuticals to polyamides, from the manufacturing of ski boots to durable frames, and from lubricants to laxatives. The present review gives an insight into the physicochemical properties of castor oil and its application. The oil is used for the production of a great variety of its derivatives. Out of many derivatives of castor oil, four are produced and utilized at a larger scale. The names of the four derivates are ricinoleic acid, sebacic acid, undecylenic acid, and γ‐decalactone. The review will aim toward an insight into the evolved techniques for the manufacturing of these derivatives of castor oil, the biotechnological route of production, and metabolic engineering approaches. Though the industrial significance of castor oil and its derivatives had been known for ages, methods for their production are continuously changing.
An artificial‐intelligence‐based age‐specific template construction framework for brain structural analysis using magnetic resonance images
Authors: Gu Dongdong , Shi Feng , Hua Rui , Wei Ying , Li Yufei , Zhu Jiayu , Zhang Weijun , Zhang Han , Yang Qing , Huang Peiyu , Jiang Yi , Bo Bin , Li Yao , Zhang Yaoyu , Zhang Minming , Wu Jinsong , Shi Hongcheng , Liu Siwei , He Qiang , Zhang Qiang , Zhang Xu , Wei Hongjiang , Liu Guocai , Xue Zhong , Shen Dinggang ,   the Consortium of Chinese Brain Molecular and Functional Mapping (CBMFM)
Published: October 2022

AbstractIt is an essential task to construct brain templates and analyze their anatomical structures in neurological and cognitive science. Generally, templates constructed from magnetic resonance imaging (MRI) of a group of subjects can provide a standard reference space for analyzing the structural and functional characteristics of the group. With recent development of artificial intelligence (AI) techniques, it is desirable to explore AI registration methods for quantifying age‐specific brain variations and tendencies across different ages. In this article, we present an AI‐based age‐specific template construction (called ASTC) framework for longitudinal structural brain analysis using T1‐weighted MRIs of 646 subjects from 18 to 82 years old collected from four medical centers. Altogether, 13 longitudinal templates were constructed at a 5‐year age interval using ASTC, and tissue segmentation and substructure parcellation were performed for analysis across different age groups. The results indicated consistent changes in brain structures along with aging and demonstrated the capability of ASTC for longitudinal neuroimaging study.
Influence of the COVID‐19 pandemic on self‐reported urinary incontinence during pregnancy and postpartum: A prospective study
Authors: Ferrari Amerigo , Corazza Ilaria , Mannella Paolo , Simoncini Tommaso , Bonciani Manila 
Published: October 2022

AbstractObjectiveTo explore how the COVID‐19 pandemic influenced self‐reported occurrence and severity of pregnancy‐related urinary incontinence (UI) in the maternity pathways of Tuscany, Italy.MethodsIn this prospective pre‐post cohort study, we selected a pre‐pandemic (n = 1018) and a post‐pandemic (n = 3911) cohorts of women that completed, from the first trimester until 3 months postpartum, three surveys including validated patient‐reported outcome measures for UI. Data were obtained from systematic surveys on the maternity pathways of Tuscany from March 2019 to June 2021. We performed panel regression models to explore how UI risk differed between COVID‐19 groups.ResultsUI occurred less frequently and less severely in post‐pandemic patients—especially stress/mixed UI in women never performing pelvic floor muscle training (PFMT)—whereas no difference emerged in women performing during‐pregnancy PFMT. During COVID‐19, obese women had higher risk of UI, whereas women undergoing operative delivery had lower risk. The post‐pandemic group reported more severe UI symptoms at the third trimester, but less severe UI postpartum in women suffering from UI during pregnancy.ConclusionsDuring the COVID‐19 pandemic, women reported fewer UI symptoms because they might have lacked chances to identify UI symptoms as a result of pandemic‐related sedentarism and inactivity. The risk in women performing during‐pregnancy PFMT was not increased, but just six of 26 health districts organized remote PFMT sessions, thus revealing limited resilience to the pandemic in Tuscany.
An automatic channel selection method based on the standard deviation of wavelet coefficients for motor imagery based brain–computer interfacing
Authors: Mahamune Rupesh , Laskar Shahedul H. 
Published: October 2022

AbstractThe redundant data in multichannel electroencephalogram (EEG) signals significantly reduces the performance of brain–computer interface (BCI) systems. By removing redundant channels, a channel selection strategy increases the classification accuracy of BCI systems. In this work, a novel channel selection method (stdWC) based on the standard deviation of wavelet coefficients across channels is proposed to identify Motor Imagery (MI) based EEG signals. The wavelet coefficients are calculated by employing a Continuous Wavelet Transform (CWT) filter bank to decompose each trial from the EEG channel. The wavelet coefficient's standard deviation values are obtained across the channels, and these values are then sorted to determine the EEG channels with the highest standard deviation values. The channels with the largest wavelet coefficient divergence are chosen. MI trials are then spatially filtered with the Common Spatial Pattern (CSP), and CWT filter bank‐based 2D images are generated from the spatially filtered trials. These images are then classified using a unique nine‐layered convolutional neural network (CNN) model that combines two feature maps acquired with differing filter sizes. The proposed framework (stdWC‐CSP‐CNN) is evaluated using kappa score and classification accuracy on two publically accessible datasets (BCI Competition III dataset IVa and BCI Competition IV dataset 2a). The suggested framework achieved a mean test classification accuracy of 88.8% for dataset IVa from BCI Competition III and 75.03% for dataset 2a from BCI Competition IV, according to the results. The proposed channel selection method outperforms the other channel selection methods examined, according to the results. By rejecting redundant channels, the whole framework can improve the performance of MI‐based BCIs.
28‐day repeated dose toxicity and toxicokinetics study on new melatonergic antidepressant GW117 in beagle dogs
Authors: Gao Mei , Chen Kai , Gu Wei , Liu Xiaoyu , Liu Tianbin , Ying Yong , Cao Chong , Zhang Yanhua , Zhang Daizhou , Yang Guiwen 
Published: October 2022

AbstractGW117 is new melatonergic antidepressant being developed to show better antidepressant action than agomelatine. The purpose of this study was to evaluate the toxicity and to determine potential target organs after oral (gavage) administration of the test article GW117 for 28 days and to assess the reversibility after a 4‐week recovery phase in beagle dogs. Toxicokinetics was also evaluated. Four groups were designed in this study, including the vehicle control group and the GW117 50, 150 and 500 mg/kg/day groups, with 5 dogs/sex/group. Body weight, hematology, clinical chemistry, gross necropsy, organ weight, histopathology, and other indicators were examined. Results showed that animals dosed at ≥150 mg/kg/day showed gastrointestinal reactions (watery feces and dark green/red brown feces), with a dose–response relationship in the incidence and severity grade. Female dogs at 500 mg/kg/day had an increase in organ weight and ratios of the liver at the end of the dosing phase. Histopathology examination showed that some animals at 500 mg/kg/day, especially female animals, had minimal centrilobular hepatocyte hypertrophy in the liver, which reversed after 28‐day recovery. With the exception of the above, no GW117‐related abnormality was noted. Meanwhile, there were no sexual differences in drug exposure and accumulation after the first and last dosing. The no observed adverse effect dose level (NOAEL) was 150 mg/kg/day, under which mean Cmax and AUC0 → t were 583.5 and 2767.0 ng/ml*h for females and 663.2 and 4046.3 ng/ml*h for males on Day 28.
Preparation, physicochemical characterization, and in vitro and in vivo osteogenic evaluation of a bioresorbable, moldable, hydroxyapatite/poly(caprolactone‐co‐lactide) bone substitute
Authors: Wu Yuhan , Zeng Wenyi , Xu Jiayun , Sun Yang , Huang Yucheng , Xiang Dong , Zhang Chenguang , Fu Zheng , Deng Feilong , Yu Dongsheng 
Published: October 2022

AbstractUse of bioresorbable artificial bone substitutes is anticipated for bone augmentation in dental implant surgery because they are relatively economical and uniform in quality compared to heterogeneous bone. In this study, a new shapable, rubbery, bioresorbable bone substitute was developed. The material was prepared by ultrasonically dispersing hydroxyapatite (HA) particles throughout a poly (caprolactone‐co‐lactide) (PCLLA) rubbery matrix. Physiochemical properties of the bone substitute including its composition, deformability, anti‐collapse ability, degradation behavior, and in vitro and in vivo osteogenic ability were evaluated. Results revealed that HA/PCLLA, which consists of homogeneously dispersed HA particles and a rubbery matrix composed of PCLLA, possesses a deformable capacity. The result of the mass retention rate of the material indicated an excellent durability in an aqueous environment. Further, the effects of HA/PCLLA on cell functions and bone‐regenerated performance were evaluated in vitro and in vivo. The results showed that HA/PCLLA had enhanced proliferative capacity, and ability to undergo osteogenic differentiation and mineralization in vitro. It was also found that HA/PCLLA had an appropriate degradation rate to induce consecutive new bone formation without collapse at the early stage in vivo, as well as the ability to maintain the contour of the bone‐grafting area, which is comparable to the deproteinized bovine bone mineral. These results indicated that HA/PCLLA is a promising bioresorbable bone substitute with properties that meet clinical requirements, including deformability, resistance to collapse in an aqueous environment, appropriate early‐stage degradation rate, biocompatibility, osteogenic bioactivity and the capacity to regenerate bone tissue with favorable contour.
Multiple sensitive eco‐friendly analytical approaches for the determination of two fourth‐generation fluoroquinolones: Application to stability study and content uniformity testing
Authors: El Gammal Reem N. , El‐Wasseef Dalia R. , El‐Ashry Saadia M. , Hammouda Mohammed E. A. 
Published: October 2022

AbstractMultiple sensitive eco‐friendly analytical techniques were applied for the assessment of two important fourth‐generation fluoroquinolones namely, gemifloxacin (GFX), and gatifloxacin (GTF). GFX, which is utilized as an essential adjunct therapy for the management of pneumonia in SARS‐CoV‐2 was determined by green indicating micellar liquid chromatographic in authentic powder and dosage forms. The separation was performed by using a reversed‐phase C18 column; the micellar mobile phase comprised of 12.5% n‐propanol, 0.15 M sodium lauryl sulfate, and 0.3% triethylamine in 0.02 M O‐phosphoric acid adjusted to pH 3.0 and pumped at 1 ml/min flow rate and detected at 266 nm by UV detection. The method was linear over the range of 4.0–90 μg.ml−1 with a recovery percentage of 99.81 ± 0.69. The acidic degradation behavior of GFX along with the kinetic investigation was evaluated as recommended by ICH‐stress conditions. The separation of the degradation product was performed in good elution time (less than 8 min), and the suggested technique has a good reproducibility (R.S.D. less than 1.0%) and provides an excellent resolution (Rs = 4.5) between GFX and its degradation product. Concerning the second drug, GTF, simple, extremely sensitive, and accurate spectrofluorimetric and spectrophotometric techniques were adopted for the determination of the drug in its pharmaceutical preparations. The suggested approaches utilize the concept of complex formation with eosin Y in an aqueous buffered solution. Regarding the spectrophotometric method (method I), the binary complex has a maximum absorption at 544 nm, while for spectrofluorimetric determination (method II) the formed complex was recorded at λem 491 nm after excitation at 286 nm. For both approaches, variables affecting the formation of the binary complexes were extensively investigated and optimized. The suggested techniques were shown to be rectilinear across the concentration range of 0.5–8 and 0.05–1 μg.ml−1, respectively, with recovery percentages of 100.34 ± 0.85 and 99.90 ± 0.81 for method (I) and method (II), respectively. In compliance with ICH guidelines, the analytical performance of the suggested techniques was thoroughly validated. Moreover, uniformity testing was also applied successfully for the evaluation of GFX by the proposed micellar liquid chromatographic method. To ensure the proposed methodology's greenness, The AGREE calculator software was adopted and the results obtained revealed an excellent greenness of the proposed approaches.
Association between antispasmodics and detection of lesions by screening esophagogastroduodenoscopy
Authors: Iwagami Hiroyoshi , Seta Takeshi , Nakano Shogo , Wakita Midori , Konishi Takafumi , Matsumoto Hisakazu , Nakatani Yasuki , Akamatsu Takuji , Urai Shunji , Uenoyama Yoshito , Yamashita Yukitaka , Nakayama Takeo 
Published: October 2022

AbstractBackground and AimWhether administration of antispasmodics as a component of premedication contributes to detection of lesions by screening esophagogastroduodenoscopy (EGDS) remains unclear. Our primary aim was to investigate this possibility.MethodsThe cohort in this retrospective study comprised consecutive asymptomatic individuals who had undergone screening EGDS as part of a health check‐up at the Japanese Red Cross Wakayama Medical Center from October 2015 to September 2020. The investigated lesions comprised esophageal squamous cell carcinoma or adenocarcinoma, gastric adenoma or adenocarcinoma, and duodenal adenoma or adenocarcinoma.ResultsTargeted lesions were detected in 72 of 31 484 participants (0.23%), 18 260 and 13 224 of whom had received and not received pre‐procedure antispasmodics, respectively. The rates of detection of lesions in these groups were 0.21% (38/18260) and 0.26% (34/13224), respectively (P = 0.40). Multivariate logistic regression analysis showed no association between administration of antispasmodics and rates of detection of targeted lesions [P = 0.24, Odds ratio (95% CI): 1.46 (0.78–2.75)].ConclusionsAntispasmodics, which were administered to more than half of the study cohort, did not improve the rate of detection of targeted lesions.
Impact of the SARS‐CoV‐2 pandemic on the health of individuals with intoxication‐type metabolic diseases—Data from the E‐IMD consortium
Authors: Mütze Ulrike , Gleich Florian , Barić Ivo , Baumgartner Mathias , Burlina Alberto , Chapman Kimberly A. , Chien Yin‐Hsiu , Cortès‐Saladelafont Elisenda , De Laet Corinne , Dobbelaere Dries , Eysken Francois , Gautschi Matthias , Santer Rene , Häberle Johannes , Joaquín Clara , Karall Daniela , Lindner Martin , Lund Allan M. , Mühlhausen Chris , Murphy Elaine , Roland Dominique , Ruiz Gomez Angeles , Skouma Anastasia , Grünert Sarah C. , Wagenmakers Margreet , Garbade Sven F. , Kölker Stefan , Boy Nikolas 
Published: October 2022

AbstractThe SARS‐CoV‐2 pandemic challenges healthcare systems worldwide. Within inherited metabolic disorders (IMDs) the vulnerable subgroup of intoxication‐type IMDs such as organic acidurias (OA) and urea cycle disorders (UCD) show risk for infection‐induced morbidity and mortality. This study (observation period February 2020 to December 2021) evaluates impact on medical health care as well as disease course and outcome of SARS‐CoV‐2 infections in patients with intoxication‐type IMDs managed by participants of the European Registry and Network for intoxication type metabolic diseases Consortium (E‐IMD). Survey's respondents managing 792 patients (n = 479 pediatric; n = 313 adult) with intoxication‐type IMDs (n = 454 OA; n = 338 UCD) in 14 countries reported on 59 (OA: n = 36; UCD: n = 23), SARS‐CoV‐2 infections (7.4%). Medical services were increasingly requested (95%), mostly alleviated by remote technologies (86%). Problems with medical supply were scarce (5%). Regular follow‐up visits were reduced in 41% (range 10%–50%). Most infected individuals (49/59; 83%) showed mild clinical symptoms, while 10 patients (17%; n = 6 OA including four transplanted MMA patients; n = 4 UCD) were hospitalized (metabolic decompensation in 30%). ICU treatment was not reported. Hospitalization rate did not differ for diagnosis or age group (p = 0.778). Survival rate was 100%. Full recovery was reported for 100% in outpatient care and 90% of hospitalized individuals. SARS‐CoV‐2 impacts health care of individuals with intoxication‐type IMDs worldwide. Most infected individuals, however, showed mild symptoms and did not require hospitalization. SARS‐CoV‐2‐induced metabolic decompensations were usually mild without increased risk for ICU treatment. Overall prognosis of infected individuals is very promising and IMD‐specific or COVID‐19‐related complications have not been observed.