bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity and reliability of the German translation of the Diabetes Foot Self-Care Behavior Scale (DFSBS-D)
Authors: Lecker Linda , Stevens Martin , Thienel Florian , Lazovic Djordje , van den Akker-Scheek Inge , Seeber Gesine H. 
Published: June 2022

Introduction
Comprehensive regular foot self-care is one of the most critical self-management behaviors for people with diabetes to prevent foot ulcer development and related complications. Yet, adequate foot self-care is only practiced by very few of those affected. To improve diabetic foot syndrome prevention, a valid and reliable instrument for measuring daily foot-care routines in patients with diabetes is needed. However, no such instrument is currently available in the German language. This study, therefore, aims to translate and cross-culturally adapt the "Diabetic Foot Self-Care Behavior Scale" (DFSBS) into German (DFSBS-D) and evaluate its validity and reliability.

Material and methods
The DFSBS was translated from English into German using a forward-backward procedure as per previous recommendations. Factor analysis was used to study structural validity. To establish construct validity, 21 a priori hypotheses were defined regarding the expected correlation between scores on the new German version (i.e., DFSBS-D) and those of the following questionnaires measuring related constructs: (1) German version "Diabetes Self-Care Activities Measure" (SDSCA-G), (2) "Frankfurter Catalogue of Foot Self-Care" (FCFSP), and (3) "Short Form 36" (SF-36) and tested in 82 patients. To assess test-retest reliability, patients completed the DFSBS-D again after a 2-week interval. Test-retest reliability was assessed from stable patients’ data (n = 48) by calculating two-way random-effects absolute agreement ICCs with 95% CI and Bland and Altman analyses. In addition, Cronbach’s alpha was calculated as internal consistency measure.

Results
The 7-item DFSBS-D showed good structural validity. Its single factor explains 57% of the total sample variance. Of the 21 predefined hypotheses, 13 (62%) were confirmed. The DFSBS-D’s internal consistency was good (Cronbach’s alpha = 0.87). Test-retest reliability over a 2-week interval was also good (ICC 0.76).

Conclusion
The DFSBS was successfully translated into German. Statistical analyses showed good DFSBS-D structural validity, test-retest reliability, and internal consistency. Yet, construct validity may be debated.
Efficacy and safety of FOLFIRI/aflibercept (FA) in an elderly population with metastatic colorectal cancer (mCRC) after failure of an oxaliplatin-based regimen
Authors: Martínez-Lago Nieves , Cameselle García Soledad , Alonso de Castro Beatriz , Gómez-Randulfe Rodríguez Martín I. , Carmona Campos Marta , González Villarroel Paula , Salgado Fernández Mercedes , De la Cámara Gómez Juan C. , Romero Reinoso Carlos , Cousillas Castiñeiras Antía , Méndez Méndez José Carlos , Vidal Insua Yolanda , Fernández-Montes Ana 
Published: June 2022

Background
The VELOUR study showed the benefit of FOLFIRI-Aflibercept (FA) versus FOLFIRI in patients with metastatic colorectal cancer (mCRC) in second-line treatment. However, only 36% of the included patients were ≥65 years. Thus, we seek to evaluate the efficacy and safety of FA in the elderly population in the context of routine practice.

Materials and methods
We conducted an observational, retrospective, multicenter, observational study of patients ≥70 years with mCRC treated with FA after progression to oxaliplatin chemotherapy in routine clinical practice in 9 hospitals of the GITuD group.

Results
Of 388 patients treated with FA between June 2013 and November 2018, 75 patients ≥70 years were included. The median number of cycles was 10 and the objective response (ORR) and disease control rates (DCR) were 33.8% and 72.0%, respectively. With a median follow-up of 27.1 months, median Progression-free survival (PFS) was 6.6 months and median Overall Survival (OS) was 15.1 months. One third fewer metastasectomies were performed in the ≥75 years’ subgroup (24 vs. 52%, p = 0.024) and more initial FOLFIRI dose reductions (68 vs. 36%, p = 0.014). ORR (23.8% vs. 38.3%), DCR (42.8% vs. 85.1%), and PFS (4 vs. 7.8 months; p = 0.017) were significantly less, without difference in OS (9.9 vs. 17.1 months; p = 0.129). The presence of prior hypertension (HT) (PFS 7.9 vs. 5.7 months, p = 0.049) and HT ≥ grade 3 during treatment (PFS 7.6 vs. 6.6 months, p = 0.024) were associated with longer PFS. The most frequent grade 3/4 adverse events were: asthenia (21.3%), neutropenia (14.7%), and diarrhea (14.7%). 57.3% required FOLFIRI dose reduction; 34.7% of aflibercept, including discontinuation (5.3% and 18.7%, respectively).

Conclusions
FA combination is effective in patients ≥70 years. The occurrence of HT is predictive of efficacy. Close monitoring of toxicity and initial dose adjustment is recommended.
Self-reported physical activity and different cardiovascular diseases—Results from updated measurements over 40 years
Authors: Lind Lars , Zethelius Björn , Byberg Liisa 
Published: June 2022

Background
Self-reported leisure-time physical activity (PA) has previously been linked to risk of cardiovascular disease (CVD). We now aim to investigate the strength of associations between PA and different CVDs and how the risk varies with age.

Methods
PA and traditional CV risk factors assessed by a questionnaire on a four-level scale in 2,175 men at age 50 years in the ULSAM study. Examinations were thereafter repeated at ages 60, 70, and 77.

Results
During 40 years follow-up, 883 individuals experienced a CVD (myocardial infarction, stroke, or heart failure). Using data from all four examinations, a graded reduction in risk of incident CVD was seen with increasing PA (HR 0.84, 95%CI; 0.77–0.93, p = 0.001 for trend test). PA was related to myocardial infarction (HR 0.84, 95%CI; 0.74–0.95, 490 cases), heart failure (HR 0.79, 95%CI; 0.68–0.91, 356 cases), but only of borderline significance vs ischemic stroke (HR 0.85, 95%CI; 0.73–1.00, 315 cases) when the CVDs were analyzed separately. Adjusting for traditional CV risk factors attenuated all relationships between PA and incident CVD, and PA did not improve discrimination of CVD when added on top of risk factors. When 10-year risk was calculated from each examination, age 70 was the time-point when PA was most closely related to incident CVD.

Conclusion
Leisure-time physical activity is related to future CVD. This was most evident at 70 years of age. If a causal relationship between self-reported PA and CVD exists, this relationship might to a major degree be mediated by traditional risk factors.
Could the ketogenic diet induce a shift in thyroid function and support a metabolic advantage in healthy participants? A pilot randomized-controlled-crossover trial
Authors: Iacovides Stella , Maloney Shane K. , Bhana Sindeep , Angamia Zareena , Meiring Rebecca M. 
Published: June 2022

Background
The ketogenic diet (KD) has been shown to result in body mass loss in people with disease as well as healthy people, yet the effect of the KD on thyroid function and metabolism are unknown.

Objective
We aimed to determine the effects of a KD, compared with an isocaloric high-carbohydrate low-fat (HCLF) diet, on resting metabolic rate and thyroid function in healthy individuals.

Design
Eleven healthy, normal-weight participants (mean(SD) age: 30(9) years) completed this randomized crossover-controlled study. For a minimum of three weeks on each, participants followed two isocaloric diets: a HCLF diet (55%carbohydrate, 20%fat, 25%protein) and a KD (15%carbohydrate, 60%fat, 25% protein), with a one-week washout period in-between. Importantly, while on the KD, the participants were required to remain in a state of nutritional ketosis for three consecutive weeks. Crossover analyses and linear mixed models were used to assess effect of diet on body mass, thyroid function and resting metabolic rate.

Results
Both dietary interventions resulted in significant body mass loss (p<0.05) however three weeks of sustained ketosis (KD) resulted in a greater loss of body mass (mean (95%CI): -2.9 (-3.5, -2.4) kg) than did three weeks on the HCLF diet (-0.4 (-1.0, 0.1) kg, p < 0.0001). Compared to pre-diet levels, the change in plasma T3 concentration was significantly different between the two diets (p = 0.003), such that plasma T3 concentration was significantly lower following the KD diet (4.1 (3.8, 4.4) pmol/L, p<0.0001) but not different following the HCLF diet (4.8 (4.5, 5.2) pmol/L, p = 0.171. There was a significant increase in T4 concentration from pre-diet levels following the KD diet (19.3 (17.8, 20.9) pmol/L, p < 0.0001), but not following the HCLF diet (17.3 (15.7, 18.8) pmol.L, p = 0.28). The magnitude of change in plasma T4 concentration was not different between the two diets (p = 0.4). There was no effect of diet on plasma thyroid stimulating hormone concentration (p = 0.27). There was a significantly greater T3:T4 ratio following the HCLF diet (0.41 (0.27, 0.55), p < 0.0001) compared to pre-diet levels but not following the KD diet (0.25 (0.12, 0.39), p = 0.80).

Conclusions
Although the diets were isocaloric and physical activity and resting metabolic rate remained constant, the participants lost more mass after the KD than after the HCLF diet. The observed significant changes in triiodothyronine concentration suggest that unknown metabolic changes occur in nutritional ketosis, changes that warrant further investigation.

Trial registration
Pan African Clinical Trial Registry: PACTR201707002406306 URL: https://pactr.samrc.ac.za/.
Identification and validation of a prognostic signature related to hypoxic tumor microenvironment in cervical cancer
Authors: Nie Chenyu , Qin Haixia , Zhang Li 
Published: June 2022

BackgroundHypoxia is a common microenvironment condition in most malignant tumors and has been shown to be associated with adverse outcomes of cervical cancer patients. In this study, we investigated the effects of hypoxia-related genes on tumor progress to characterize the tumor hypoxic microenvironment.MethodsWe retrieved a set of hypoxia-related genes from the Molecular Signatures Database and evaluated their prognostic value for cervical cancer. A hypoxia-based prognostic signature for cervical cancer was then developed and validated using tumor samples from two independent cohorts (TCGA-CESC and CGCI-HTMCP-CC cohorts). Finally, we validated the hypoxia prediction of ccHPS score in eight human cervical cancer cell lines treated with the hypoxic and normoxic conditions, and 286 tumor samples with hypoxic category (more or less) from Gene Expression Omnibus (GEO) database with accession GSE72723.ResultsA risk signature model containing nine hypoxia-related genes was developed and validated in cervical cancer. Further analysis showed that this risk model could be an independent prognosis factor of cervical cancer, which reflects the condition of the hypoxic tumor microenvironment and its remodeling of cell metabolism and tumor immunity. Furthermore, a nomogram integrating the novel risk model and lymphovascular invasion status was developed, accurately predicting the 1-, 3- and 5-year prognosis with AUC values of 0.928, 0.916 and 0.831, respectively. These findings provided a better understanding of the hypoxic tumor microenvironment in cervical cancer and insights into potential new therapeutic strategies in improving cancer therapy.
A biopsychosocial examination of chronic back pain, limitations on usual activities, and treatment in Brazil, 2019
Authors: Andrade Flavia Cristina Drumond , Chen Xiayu Summer 
Published: June 2022

Background
Chronic back pain is prevalent in Brazil, leading to enormous healthcare costs and social burdens. It also disproportionately affects low-income and less-healthy people.

Objectives
This study examines the associations of chronic back pain with biological, psychological, and social factors; how it limits usual activities; and how chronic back pain influences the use of treatment services.

Methods
Using Brazil’s National Health Survey (PNS-2019), multivariate logistic regressions were conducted to examine how biological, psychological, and social factors correlate with chronic back pain, limitations on usual activities, and pain treatment.

Results
PNS-2019 data showed that 23.4% (95% CI 22.8–24.0) of Brazilian adults aged over 20 reported back pain. A higher prevalence of chronic back pain was associated with biological factors (older age, being female, overweight or obese, current smoking, and having more chronic conditions), lower social conditions (low education, low per capita household income, non-married, and living in rural areas), and poor psychological health (more depressive symptoms). Chronic back pain is more likely to limit usual activities among those with low social conditions (lower education, lower income), poor physical and behavioral health (obese, current smokers, and those with a greater number of chronic conditions), and worse psychological health (more depressive symptoms). However, married people and those who do not consume alcohol were also more likely to report limited activities. Among those with back pain, 68% received at least one form of treatment. Those with intense limitations on their usual activities were 2.2 times as likely to report treatment. People with higher social conditions (higher income, college education, and private health insurance) were more likely to receive treatment.

Conclusion
The results show significant biological, psychological, and social disparities in the prevalence of chronic back pain in Brazil. The findings point to the need for tailored policies and prevention programs with attention to vulnerable groups. Even though Brazil has universal health care, those with better socioeconomic conditions are more likely to receive treatment.
Game Production Studies, Olli Sotamaa and Jan Švelch (eds) (2021)
Authors: Shelton James 
Published: June 2022

Review of: Game Production Studies, Olli Sotamaa and Jan Švelch (eds) (2021)
Amsterdam: Amsterdam University Press, 356 pp.,
ISBN 978-9-46372-543-9, e-book open access, h/bk, EU €109.00
Estudio de las medidas sancionadoras y reparadoras del abuso en la contratación temporal en el empleo público contempladas en la Ley 20/2021 y en el Real Decreto-Ley 32/2021, con especial referencia a la figura del personal indefinido no fijo
Authors: Terradillos Ormaechea Miren Edurne 
Published: June 2022

El trabajo analiza las distintas clases de respuestas jurídicas deparadas por el ordenamiento jurídico actual (Ley 20/2021 y Real Decreto-Ley 32/2021) al abuso e incumplimiento de la regulación jurídica sobre contratación temporal laboral en el empleo público acaecida en el pasado reciente.

La figura del personal indefinido no fijo (INF), figura creada por la jurisprudencia laboral, ha sido la sanción jurídica más eficaz contra el abuso desde los inicios de los incumplimientos públicos y abusos cometidos por la Administración en la contratación pública. Sin embargo, en el primer apartado de este trabajo se demostrará que tras un resurgimiento del INF logrado merced de un importante pronunciamiento del TJUE, que parecía alinearse con esta figura, las dos normas jurídicas aprobadas a finales de 2021 han acabado con esa figura.

Los otros focos de este estudio se dirigen a analizar las vías legales de estabilización del empleo temporal, señaladamente, los procedimientos de concurso-oposición, y el excepcional del concurso de méritos. Se recurrirá para ello a una comparación en línea con el Acuerdo Marco sobre el trabajo de duración determinada (Directiva 1999/70/CE), que ha sido interpretado por el Tribunal de Justicia de la Unión Europea (TJUE). Los aciertos y posibles desaciertos de la nueva regulación jurídica sobre el empleo público laboral temporal serán también señalados.
UMA ANÁLISE INTEGRATIVA DE FRAMEWORKS DE IMPLEMENTAÇÃO DA GESTÃO DO CONHECIMENTO: PROPOSTA DE UMA AGENDA DE PESQUISA
Authors: De Borba Darci , Chaves Marcirio Silveira 
Published: June 2022

Objetivo: Este artigo analisa as características dos frameworks de implementação da Gestão do Conhecimento (GC) publicados em revistas de alto impacto e responde à seguinte questão de pesquisa: Como se caracterizam os frameworks de implementação da GC?
Design/metodologia/abordagem: Por meio de uma revisão de literatura, identificaram-se 10 frameworks de implementação da GC, que foram analisados individualmente e estruturados quanto às suas dimensões e variáveis, bem como os pilares e os processos da GC.
Resultados: A análise individual de cada framework permitiu a geração de um quadro integrativo que orienta os rumos da pesquisa no campo. Os frameworks também são classificados em descritivos e prescritivos. A análise dos frameworks ainda evidenciou lacunas em medição dos processos, medição dos resultados e soluções que vislumbram a TI como estrutura fundamental para a GC. Além do quadro integrativo, este artigo também propõe uma agenda de pesquisa para propiciar estudos empíricos e a aplicação dos frameworks de GC.
Limitações/implicações da pesquisa: Este estudo se limitou aos frameworks de implementação de GC, logo, artigos que porventura apresentassem outras estruturas não foram contemplados na análise. Assim, próximas pesquisas poderão realizar um apanhado com perspectivas diferentes, mais genéricas ou mais específicas, analisando de forma individualizada os processos de GC e seus mecanismos.
Implicações práticas: Aos gestores, o estudo fomenta a discussão sobre a aplicabilidade dos frameworks de implementação invocando pesquisas mais pragmáticas e que auxiliem na medição, na aplicação e na condução dos processos de GC.
Implicações teóricas: Este artigo contribui com as pesquisas na área da GC, ao reunir frameworks de diferentes setores sob a classificação dos processos e dos pilares da GC, permitindo a identificação de lacunas ainda não preenchidas e reflexões acerca do afastamento dos profissionais das pesquisas no campo.
Originalidade/valor: Faltam alternativas adaptadas a determinados setores, por exemplo, o segmento bancário. Falta também incorporar aos frameworks o uso de modelos de maturidade de GC e indicadores para métricas do processo, que serão qualitativas e quantitativas, assim como medidas de resultado financeiras e não financeiras. O artigo consegue reunir um panorama sobre essas lacunas.
CT investigation of 3D liquid pathways in the anatomical structure of Norway spruce wood during imbibition
Authors: Martin Benoît , Colin Julien , Perré Patrick , Casalinho Joel , Mounkaila Mahamadou , Lu Pin , Rémond Romain 
Published: June 2022

Abstract
Wood permeability is a macroscopic property resulting from complex pathways at the cellular level. In this study, high-resolution X-ray CT scans were performed during longitudinal imbibition in Norway spruce to investigate the role of wood rays and tracheids network in liquid migration. A customized setup was designed to maintain the bottom face of a wooden cylinder in contact with water, without vibration, despite the sample rotation required during each scan. The results highlighted a contrasted role of latewood and earlywood in water migration. Liquid imbibition was fast in latewood, because the bordered pits are less prone to aspiration than in earlywood, due to their smaller diameter and larger cell wall thickness. In earlywood, the migration pattern was complex due to pit aspiration that isolate tracheids clusters. Indeed, the images revealed a significant contribution of wood rays in the migration pathways. Consequently, tracheids were not progressively filled in the longitudinal direction from one tracheid to the next, but they were filled laterally with water coming from wood rays at different heights of the cells. This explained entrapped air bubbles in the lumens and led to a 3D heterogeneous liquid distribution.
Two new iterative schemes to approximate the fixed points for mappings
Authors: Deshmukh Aniruddha , Gopal Dhananjay , Rakocević Vladimir 
Published: June 2022

Abstract
In this article, we present a study of two iterative schemes to approximate the fixed points of enriched non-expansive maps and enriched generalized non-expansive maps. The schemes introduced in this article generalize those given by Thakur et al. in (“A new iterative scheme for approximating fixed points of nonexpansive mappings,” Filomat, vol. 30, no. 10, pp. 2711–2720, 2016.) and Ali et al. in (“Approximation of Fixed points for Suzuki’s generalized nonexpansive mappings,” Mathematics, vol. 7, no. 6, pp. 522–532, 2019.) in a sense that our schemes work for larger classes of enriched mappings and the schemes given by Thakur et al. and Ali et al. reduce to a particular case of our iterative techniques. Taking inspiration from Berinde (“Picard iteration converges faster than Mann iteration for a class of quasi-contractive operators,” Fixed Point Theory Appl., vol. 2004, no. 2, pp. 97–105, 2004.) and Maniu (“On a three-step iteration process for Suzuki mappings with qualitative study,” Numer. Funct. Anal. Optim., 2020.), we also give stability results of the our procedures for enriched contractions (introduced by Berinde in 2019). Lastly, we compare the rate of convergence of our schemes with each other and the conventional Krasnoselskii iteration process used for approximating fixed points of enriched contractions along with some examples. As an application to the proposed iterative schemes, we give a few results on the solutions of linear system of equations.
High school EFL teachers’ oral corrective feedback beliefs and practices, and the effects of lesson focus
Authors: Ha Xuan Van 
Published: June 2022

Abstract
Teachers’ oral corrective feedback (CF) may be influenced by the communication orientation of the lessons, but little research has taken lesson focus into account when examining the relationship between teachers’ CF beliefs and practices. This study explores teachers’ CF beliefs, practices, and the relationship between the two constructs in Vietnamese high school EFL classrooms. The study also compares and contrasts the teachers’ CF practices in relation to two opposing lesson types in terms of communication orientation. The participants were ten experienced EFL teachers from two public high schools. Analysis of audio-recorded in-depth interviews and video and audio-recorded classroom observations (n = 20 lessons, 15 h) showed a strong relationship between the lesson focus and the teachers’ practices in various aspects of feedback provision. The teachers’ beliefs were reflected more consistently in grammar lessons (where the teaching is more form-focused) than in speaking lessons (where the teaching is more meaning-focused). There was also a difference in the teachers’ CF strategies used between the two lesson types. This difference could be explained by the teachers’ background and the difference in the predictability of the learning activities and learner contributions.