bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative chemotherapy for resectable colorectal liver metastases: Analysis from the Colorectal Operative Liver Metastases International Collaborative (COLOMIC)
Authors: Gawdi Rohin , Valenzuela Cristian D. , Moaven Omeed , Stauffer John A. , Del Piccolo Nico R. , Cheung Tanto , Corvera Carlos U. , Wisneski Andrew D. , Cha Charles , Russell Greg , Zarandi Nima , Dourado Justin , Shen Perry 
Published: April 2022

AbstractBackgroundChemotherapy has been increasingly combined with surgery as multimodality treatment for resectable colorectal‐liver metastases (CLM). There is paucity of clinical data addressing optimal timing of chemotherapy relative to surgery. We examined outcomes of patients undergoing hepatectomy for resectable CLM.MethodsSeven hundred and eighteen patients treated with hepatectomy for CLM were analyzed from five hepatobiliary institutions between 2000 and 2018. Overall survival (OS) was measured from time of hepatectomy for patients receiving: surgery alone, neoadjuvant, adjuvant, and neoadjuvant‐plus‐adjuvant (perioperative) chemotherapy. Kaplan–Meier analysis was performed to detect differences in OS between treatment groups. Single‐ and multi‐variable analysis with Cox proportional hazards were run for OS between groups.ResultsOne hundred and thirty‐seven patients (19.08%) received surgery, 104 (14.48%) received neoadjuvant‐only, 214 (29.81%) received adjuvant‐only, and 263 (36.63%) received perioperative chemotherapy; with median OS of 48.20, 46.83, 56.27, and 49.93 months, respectively. No differences in median OS were seen between groups on Kaplan–Meier analysis. No significant difference in Charlson‐Deyo comorbidity status was seen between groups (p = 0.853), while significant difference was seen in maximum tumor size (p = 0.0023). On multivariate analysis, adjuvant (p = 0.010) and perioperative (p = 0.020) chemotherapy were independently associated with OS compared to surgery alone.DiscussionDespite group differences, chemotherapy after surgery was independently associated with improved OS in CLM.
Magnetic solid‐phase extraction of organophosphorus pesticides from apple juice and environmental water samples using magnetic graphene oxide coated with poly(2‐aminoterephthalic acid‐co‐aniline) nanocomposite as a sorbent
Authors: Nasiri Maryam , Ahmadzadeh Hossein , Amiri Amirhassan 
Published: April 2022

An effective magnetic solid‐phase extraction method was proposed using magnetic graphene oxide coated with poly(2‐aminoterephthalic acid‐co‐aniline) as a sorbent for preconcentration and extraction of organophosphorus pesticides from environmental water and apple juice samples, and determined using the gas chromatography‐mass spectrometry analysis. To approve the successful synthesis of the magnetic nanocomposite, the prepared sorbent was characterized by field emission scanning electron microscopy, X‐ray diffraction, vibrating sample magnetometer, and Fourier transforms infrared techniques. The main parameters affecting the extraction efficiency were considered and studied to afford an optimized procedure. Systematic method validation verified its suitable recoveries (89.4–107.3%), and precision (relative standard deviations < 6.8%). The method showed a wide linear dynamic range (0.04–700 ng/mL) with low limits of detection (0.01–0.06 ng/mL) and quantification (0.04–0.21 ng/mL). This method presented good potential and great sensitivity for the pesticides determination.
Elevated fractional donor‐derived cell‐free DNA during subclinical graft injury after liver transplantation
Authors: Baumann Anna K. , Beck Julia , Kirchner Theresa , Hartleben Björn , Schütz Ekkehard , Oellerich Michael , Wedemeyer Heiner , Jaeckel Elmar , Taubert Richard 
Published: April 2022

Abstract
Personalized immunosuppression (IS) promises to improve the balance of necessary control of alloreactivity and dose‐dependent adverse effects of long‐term IS such as kidney insufficiency, infections, and malignancies. The majority of liver transplantation (LT) recipients exhibit graft injuries (graft inflammation and/or fibrosis) that are not eligible for an IS reduction according to current Banff criteria, even when liver enzymes are normal or only marginally elevated. This cross‐sectional study evaluated the noninvasive prediction of such subclinical graft injuries in surveillance liver biopsies via donor‐derived cell‐free DNA (dd‐cfDNA). Absolute and fractional dd‐cfDNA increased stepwise from patients without histological signs of rejection (n = 26) over subclinical graft injury (n = 61), including subclinical T cell–mediated rejection to clinical overt T cell–mediated rejection (n = 21). Thus, fractional plasma dd‐cfDNA was significantly elevated paired to surveillance biopsies with relevant subclinical graft injury according to 2016 Banff criteria compared with those with minimal or absent histological graft injury. In contrast, the presence of donor‐specific anti–human leukocyte antigen antibodies was not associated with the amount of dd‐cfDNA. The sensitivity and specificity of fractional dd‐cfDNA to noninvasively predict relevant subclinical graft injury was rather limited with 73% and 52% at the cutoff value of 2.1% fractional dd‐cfDNA. The positive predictive value of fractional dd‐cfDNA above 2.1% was 76% to noninvasively predict subclinical graft injury, calculated on the prevalence of graft injury in our prospective surveillance biopsy program, whereas the negative predictive values was not predictive (47%). In conclusion, dd‐cfDNA has a rather limited diagnostic fidelity in addition to other noninvasive markers for the assessment of subclinical graft injury in personalized IS approaches after LT in a cross‐sectional setting.
The effectiveness of group and home‐based exercise on psychological status in people with ankylosing spondylitis: A systematic review and meta‐analysis
Authors: Lane Brian , McCullagh Ruth , Cardoso Jefferson R. , McVeigh Joseph G. 
Published: April 2022

AbstractIntroductionAnkylosing spondylitis (AS) is an inflammatory rheumatic disease in which the physical impact has been evaluated; however, the psychological consequences are less well explored. The primary aim of this review was to determine the effectiveness of group versus home‐based exercises on psychological status of patients with AS.MethodsSix databases were searched until January 2020. Eligible studies were randomised controlled trials including group or home‐based exercise interventions. Risk of bias (RoB) was evaluated using the Cochrane RoB 2.0 tool. Relative percentage difference (RPD) between groups and effect sizes were presented as standardised mean differences (SMDs) with 95% confidence intervals (CI).ResultsFive studies met the inclusion criteria (n = 240), outcomes of interest were depression, anxiety and mental health. Three studies were low‐risk RoB, one study was high‐risk RoB and one study there was ‘some concerns’ of bias. Group‐based exercise was more effective than home‐based exercise for improving depression at 6‐week (RPD 18%) and 3‐month (RPD 42%), anxiety (RPD 17%) and mental health (RPD 20%). Home‐based exercise was more effective than control interventions for improving depression (RPD 33%). A meta‐analysis demonstrated group‐based exercises compared to home exercises, improved depression (SMD: −0.54; 95% CI: [−0.89; −0.18]; p = 0.003) and physical function (SMD: −0.49; 95% CI: [−0.84; −0.14]; p = 0.006).ConclusionSupervised group‐based demonstrated improvements in depression, anxiety and mental health compared to home‐based exercise. Individualised home‐based exercise is more effective than no intervention for improving depression in people with AS.
Randomized phase 2 study ofACE‐083, amuscle‐promotingagent, in facioscapulohumeral muscular dystrophy
Authors: Statland Jeffrey M. , Campbell Craig , Desai Urvi , Karam Chafic , Díaz‐Manera Jordi , Guptill Jeffrey T. , Korngut Lawrence , Genge Angela , Tawil Rabi N. , Elman Lauren , Joyce Nanette C. , Wagner Kathryn R. , Manousakis Georgios , Amato Anthony A. , Butterfield Russell J. , Shieh Perry B. , Wicklund Matthew , Gamez Josep , Bodkin Cynthia , Pestronk Alan , Weihl Conrad C. , Vilchez‐Padilla Juan J. , Johnson Nicholas E. , Mathews Katherine D. , Miller Barry , Leneus Ashley , Fowler Marcie , van de Rijn Marc , Attie Kenneth M. 
Published: April 2022

AbstractIntroduction/AimsFacioscapulohumeral muscular dystrophy (FSHD) is a slowly progressive muscular dystrophy without approved therapies. In this study we evaluated whether locally acting ACE‐083 could safely increase muscle volume and improve functional outcomes in adults with FSHD.MethodsParticipants were at least 18 years old and had FSHD1/FSHD2. Part 1 was open label, ascending dose, assessing safety and tolerability (primary objective). Part 2 was randomized, double‐blind for 6 months, evaluating ACE‐083240 mg/muscle vs placebo injected bilaterally every 3 weeks in the biceps brachii (BB) or tibialis anterior (TA) muscles, followed by 6 months of open label. Magnetic resonance imaging measures included total muscle volume (TMV; primary objective), fat fraction (FF), and contractile muscle volume (CMV). Functional measures included 6‐minute walk test, 10‐meter walk/run, and 4‐stair climb (TA group), and performance of upper limb midlevel/elbow score (BB group). Strength, patient‐reported outcomes (PROs), and safety were also evaluated.ResultsParts 1 and 2 enrolled 37 and 58 participants, respectively. Among 55 participants evaluable in Part 2, the least‐squares mean (90% confidence interval, analysis of covariance) treatment difference for TMV was 16.4% (9.8%‐23.0%) in the BB group (P < .0001) and 9.5% (3.2%‐15.9%) in the TA group (P = .01). CMV increased significantly in the BB and TA groups and FF decreased in the TA group. There were no consistent improvements in functional or PRO measures in either group. The most common adverse events were mild or moderate injection‐site reactions.DiscussionSignificant increases in TMV with ACE‐083 vs placebo did not result in consistent functional or PRO improvements with up to 12 months of treatment.
The peridynamic Drucker‐Prager plastic model with fractional order derivative for the numerical simulation of tunnel excavation
Authors: Zhang Ting , Zhou Xiaoping , Qian Qihu 
Published: April 2022

AbstractIn this study, the peridynamic Drucker‐Prager plastic model with fractional order derivative is proposed to investigate the plastic behavior of surrounding rocks around tunnels, in which the Caputo fractional derivative is employed due to its mathematical simplicity. Instead of utilizing just one parameter for the typical nonassociated flow rule, such as dilation angle, multiple parameters, such as fractional order and interval of fractional derivative, are used to specify the direction of plastic deformation, and the fractional derivative based‐typical flow rule is proposed. As a result, compared with the traditional peridynamic Drucker‐Prager plastic model, the proposed method is a more generalized model including the typical nonassociated flow rule. Besides, based on the PD force density, the strategy of exertion of initial stress is proposed to simulate in‐situ stress in rocks. Taking a block subjected to compression as an example, the impacts of various factors, such as fractional order and interval of fractional derivative, are investigated. A numerical simulation of tunnel excavation in rocks is carried out and the numerical results obtained by the proposed method are verified by comparing with FEM results.
Ca2+ enhanced photosensitizer/DNase I nanocomposite mediated bacterial eradication through biofilm disruption and photothermal therapy
Authors: Ran Meixin , Gounani Zahra , Yan Jiaqi , Rosenholm Jessica M. , Zhang Hongbo 
Published: April 2022

AbstractBiofilms are currently responsible for 80% of human chronic bacterial infections, being composed of bacterial communities within self‐produced extracellular polymeric substances (EPS) that can resist various adverse factors in the bacterial microenvironment. Therefore, the development of powerful antibacterial systems by disrupting biofilms first and killing exposed free‐living bacteria is the top priority for clinical antibiotic needs. In this study, we developed a pH‐ and photothermally responsive photosensitizer/enzyme‐loaded nanocomposite for enhanced biofilm disruption and bacteria killing (gram‐positive and gram negative). To achieve this, IR780 (I) as an efficient NIR dye was encapsulated inside the hydrophobic core of 1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐N‐[methoxy(polyethylene glycerol)‐2000] (DSPE‐PEG2000) micelles (M) for enhanced photothermal therapy. EPS extracellular DNA lyase deoxyribonuclease I (DNase I) was anchored on the micellar surface by calcium phosphate mineralization method. The results indicated that pH‐sensitive MI@CaPD nanocomposite degraded as a response to the acidic conditions characteristic for the bacterial environment and released DNase I and Ca2+ ions simultaneously. Subsequently, the Ca2+ stabilized the DNase I active structure and facilitated the dispersion of the biofilm EPS. Then, interior bacteria were exposed and killed by IR780‐mediated hyperthermia. The synergistic effect of DNase I and photothermal therapy could efficiently eradicate the biofilms, which exhibits superior biofilm dispersion and destruction capability.
MACPABE: Multi‐Authority‐based CP‐ABE with efficient attribute revocation for IoT‐enabled healthcare infrastructure
Authors: Das Sangjukta , Namasudra Suyel 
Published: April 2022

AbstractThe Internet of Things (IoT) technology along with cloud computing has gained much attention in recent years for its potential to upgrade conventional healthcare systems. Outsourcing healthcare data to a cloud environment from IoT devices is very essential as IoT devices are lightweight. To maintain confidentiality and to achieve fine‐grained access control, the ciphertext policy attribute‐based encryption (CP‐ABE) technique is utilized very often in an IoT‐based healthcare system for encrypting patients' healthcare data. However, an attribute revocation may affect the other users with the same attribute set, as well as the entire system due to its security concerns. This paper proposes a novel CP‐ABE‐based fine‐grained access control scheme to solve the attribute revocation problem. The proposed technique includes multiple attribute authorities to reduce the work overhead of having a single authority in the traditional CP‐ABE systems. In addition, the proposed scheme outsources the decryption process to a decryption assistant entity to reduce the decryption overhead of the end‐users. To prove the efficiency of the proposed scheme, both formal security analysis and performance comparisons are presented in this paper. Results and discussion prove the effectiveness of the proposed scheme over some well‐known schemes.
Dr. Charles L. Suffel: Scholar, teacher, mentor, friend
Authors: Gross Daniel , Kahl Nathan , Luttrell Kristi , Saccoman John T. 
Published: April 2022

AbstractDr. Charles L. Suffel (1941–2021) was an influential mathematics educator and scholar at Stevens Institute of Technology for more than half a century. The Managing Editor of Networks for 20 years, Suffel's reach extended far beyond the Stevens campus. He coauthored dozens of graph theory papers and mentored more than a dozen Ph.D. thesis students. In this article, we discuss his contributions to the field of network reliability theory and his legacy as a teacher and mentor.
Dual composite bioadhesives for wound closure applications: An in vitro and in vivo study
Authors: Eshkol‐Yogev Inbar , Tobias Tal , Keren Aviad , Gilhar Amos , Gilboa Efrat , Furer Ariel , Ullmann Yehuda , Zilberman Meital 
Published: April 2022

AbstractOver the years, new biomaterials have been introduced as an alternative to conventional wound closure methods. Compared with traditional methods including sutures and staples, bioadhesives are more convenient to use and less time‐consuming. Nevertheless, the application of topical skin adhesives such as Cyanoacrylates (CA) is limited, due to cytotoxicity. Hence, developing skin adhesives with strong adhesion to soft tissue in wet environment, controlled physical and mechanical properties, and excellent biocompatibility has been a significant challenge. In the current study, we developed a new bioadhesive based on the highly biocompatible natural polymers gelatin and alginate. In order to enhance the mechanical‐ physical properties and functionality, two types of fillers were loaded: hemostatic agent (kaolin or montmorillonite) and cellulose fibers. Our in‐vitro results show that the addition of the functional fillers increased the tensile strength and modulus of the bulk material, leading to higher sealing ability and higher bonding strength. In addition, the gelation time and swelling degree were significantly decreased and the viscosity increased with the incorporation of the filler, which enables better functioning. The in‐vivo model focused on using a porcine skin incision, demonstrated superior efficacy of these new bioadhesives compared to the control group. I.e., they resulted in rapid healing, less inflammation, and a higher degree of wound closure. In conclusion, our dual‐composite bioadhesives demonstrated promising potential for use in wound closure applications and may serve as a suitable alternative for conventional sutures. Their unique properties make them beneficial, especially for first medical care applications such as rescuing casualties.
Excellent electromagnetic interference shielding performance of polypropylene/carbon fiber/multiwalled carbon nanotube nanocomposites
Authors: Kaushal Ashish , Singh Vishal 
Published: April 2022

AbstractIn this study, we investigated the mechanical, DC conductivity, and electromagnetic interference (EMI) shielding properties of multiwalled carbon nanotubes (MWCNTs) and carbon fiber reinforced polypropylene (CNC) nanocomposites. The nanocomposites were prepared by melt processing technique using a twin‐screw extruder followed by injection molding. This combination of CF and MWCNT improved the tensile strength and modulus of the nanocomposites by up to 31.14% and 60.14%. The percolation behavior helped to improve the DC electrical conductivity from 2.07 × 10−10 to 9.58 × 10−2 s/cm. The CNC nanocomposites exhibited shielding effectiveness of 51.9 dB at maximum filler loading in the X‐band (8.2–12.4 GHz) for a 2 mm thick sample. In addition, efforts have been made to develop a compatible EMI shielding material using multiple fillers.
Boron nitride enhanced shape memory poly(aryl ether ketone) actuators with rapid self‐deformation and staged responsive behaviors
Authors: Yang Shuai , He Yang , Leng Jinsong 
Published: April 2022

AbstractIn this paper, boron nitride (BN) sheets, as two‐dimensional thermal conductive fillers, were integrated into shape memory poly(aryl ether ketone) (PAEK) matrix to improve the response speed of actuators. The thermal conductivity of composites was found to be positively correlated with the content of BN sheets. Significantly, a highest in‐plane thermal conductivity of 2.66 W m−1 K−1 was obtained, which resulted in the increase of the recovery speed of the PAEK/BN actuators from 18 to 6 s. Besides, the integration of BN sheets improved the shape memory effect of PAEK matrix, including the higher shape recovery ratio (up to 99.9%) and fixity ratio (over 97%). In addition, through the assembling of four components with designed BN contents, we achieved the interesting staged shape recovery behaviors for PAEK/BN composite actuators, which enabled programmable and smart manipulations. These fabricated PAEK/BN composite actuators with rapid response and staged deformation behaviors possessed the wide utilization potential in smart devices.
Registration of ‘Hardy 2519’ wheat
Authors: Liu Limei , Griffey Carl Allen , Brooks Wynse S. , Seago John E. , Fitzgerald Joshua , Thomason Wade , Hokanson Elizabeth G. , Behl Harry D. , Oakes Joseph , Pitman Robert M. , Dunaway David W. , Vaughn Mark E. , Lee Michelle , Barnett Marla Dale , Custis James T. , Chen Richard Y. , Fountain Myron , Marshall David , Cowger Christina , Cambron Sue , Jin Yue , Chen Xianming , Beahm Bruce , Browning Phillip , Hardiman Thomas , Osborne Scott , Lin CJ , Mennel D. Ford , Santantonio Nicholas 
Published: April 2022

Abstract‘Hardy 2519’ (Reg. no. CV‐1189, PI 692613), a hard red winter (HRW) wheat (Triticum aestivumL.) cultivar, was derived from the cross VA06HRW‐108 × ‘Vision 30’ (PI 661153) using a modified bulk breeding method. Hardy 2519 was tested as VA14HRW‐25 in replicated yield trials in Virginia (2015–2018) and in the USDA‐ARS Uniform Bread Wheat Trials (2016–2018) and released by the Virginia Agricultural Experiment Station in 2019. Hardy 2519 is a widely adapted, high‐yielding HRW wheat with 2*, 5+10 gluten subunits. Hardy 2519 is awned, semidwarf (Rht2 gene) with medium spike emergence, resistant to leaf rust, and moderately resistant to powdery mildew in the mid‐Atlantic region. In the Virginia Bread Wheat Elite Trials from 2018 to 2020, Hardy 2519 produced a mean yield of 5,393 kg ha–1, which was similar to that of the HRW wheat cultivar ‘Vision 45’ (PI 667642) at 5,267 kg ha–1. Hardy 2519 has acceptable milling and baking quality on the basis of comparisons with the HRW wheat check cultivar ‘Jagger’.
Evaluating FEV1 decline in diagnosis and management of pulmonary exacerbations in children with cystic fibrosis
Authors: Bouzek Drake C. , Ren Clement L. , Thompson Misty , Slaven James E. , Sanders Don B. 
Published: April 2022

AbstractRationaleForced expiratory volume in 1 s (FEV1) decline (ΔFEV1) is associated with pulmonary exacerbation (PEx) diagnosis in cystic fibrosis (CF). Spirometry may not be available during telehealth visits and could impair clinician ability to diagnose PEx. This study aims to (1) identify the associations between degrees of ΔFEV1 (decrease of <5% predicted vs. 5%−9% predicted vs. ≥10% predicted from baseline), clinical symptoms, and clinician‐diagnosed PEx and (2) evaluate the correlation between respiratory symptoms, ΔFEV1, and antibiotic treatment.MethodsRetrospective, descriptive study of PEx diagnosis and management in 628 outpatient clinical encounters with spirometry in 178 patients with CF ages 6−17 years at Riley Hospital for Children during 2019. Odds ratios (OR) of symptoms associated with clinician‐defined PEx diagnosis and antibiotic management stratified by ΔFEV1 decline were determined.ResultsClinician‐diagnosed PEx occurred at 199 (31.7%) visits; increased cough (77.4%) and sputum/wet cough (57.8%) were the most frequently reported symptoms. Compared to no ΔFEV1, the odds of a clinician‐diagnosed PEx were increased when ΔFEV15%−9% and ΔFEV1≥10% was present with increased cough (OR 1.56, 95% confidence interval [CI] 1.25−1.94 and OR 1.82, 95% CI 1.52−2.19, respectively), increased sputum (OR 1.59, 95% CI 1.20−2.12 and OR 1.78, 95% CI 1.37−2.32, respectively), and increased cough and sputum together (OR 1.51, 95% CI 1.08−2.13 and OR 1.68, 95% CI 1.22−2.31, respectively).ConclusionsΔFEV1 is associated with increased likelihood that cough and sputum are diagnosed as a PEx. Spirometry is essential for PEx diagnosis and treatment and is a necessary component of all clinical encounters.