bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of deep learning-based computer aided diagnostic system in improving diagnostic performance of rib fractures in acute blunt trauma
Authors: Tan Hui , Xu Hui , Yu Nan , Yu Yong , Duan Haifeng , Fan Qiuju , Tian Zhanyu 
Published: March 2022

Abstract
IntroductionTo evaluate the value of a deep learning-based computer-aided diagnostic system (DL-CAD) in improving the diagnostic performance of acute rib fractures in patients with chest trauma.Materials and MethodsCT images of 214 patients with acute blunt chest trauma were retrospectively analyzed by two interns and two attending radiologists independently firstly and then with the assistance of a DL-CAD one month later, in a blinded and randomized manner. The consensus diagnosis of fib fracture by another two senior thoracic radiologists was regarded as reference standard. The rib fracture diagnostic sensitivity, specificity, positive predictive value, diagnostic confidence and mean reading time with and without DL-CAD were calculated and compared.ResultsThere were 680 rib fracture lesions confirmed as reference standard among all patients. The diagnostic sensitivity and positive predictive value of interns were significantly improved from (68.82%, 84.50%) to (91.76%, 93.17%) with the assistance of DL-CAD, respectively. Diagnostic sensitivity and positive predictive value of interns assisted by DL-CAD were comparative to those of attendings aided by DL-CAD (94.56%, 86.47%) or not aided (95.67%, 93.83%), respectively. In addition, when radiologists were assisted by DL-CAD, the mean reading time was significantly reduced and diagnostic confidence was significantly enhanced.ConclusionsDL-CAD improves the diagnostic performance of acute rib fracture in chest trauma patients, which increases the diagnostic confidence, sensitivity and positive predictive value for radiologists. DC-CAD can advance the diagnostic consistency of radiologists with different experiences.
Comparison of patient-reported outcomes at one year after injury between limb salvage and amputation: A prospective cohort study
Authors: Kurozumi Taketo , Inui Takahiro , Nakayama Yuhei , Honda Akifumi , Matsui Kentaro , Ishii Keisuke , Suzuki Takashi , Watanabe Yoshinobu 
Published: March 2022

Abstract
Purpose: This single-centre, prospective cohort study aimed to compare the patient-reported outcomes at one year after injury between limb salvage and amputation and to elucidate whether amputation contributes to early recovery of functionality and quality of life.Methods: We included 47 limbs of 45 patients with severe open fractures of the lower limb and categorised them into limb salvage and amputation groups. Data on patient-reported outcomes at one year after injury were obtained from the Database of Orthopedic Trauma by the Japanese Society for Fracture Repair at our centre. Patients’ limbs were evaluated using the lower extremity functional scale (LEFS) and Short-Form 8 (SF-8). Early recovery was evaluated using functionality and quality-of-life questionnaires.Results: Of the 47 limbs, 34 limbs of 34 patients were salvaged and 13 limbs of 11 patients were amputated. Significant differences were noted between the limb salvage and amputation groups in terms of the LEFS scores (mean: 49.5 vs 33.1, P=0.025) and scores for the mental health component (mean: 48.7 vs 38.7, P=0.003), role–physical component (mean: 42.2 vs 33.3, P=0.026), and mental component summary (mean: 48.2 vs 41.3, P=0.042) of the SF-8. The limb salvage group had better scores than did the amputation group. Conclusions: As reconstruction technology has advanced and limb salvaging has become possible, the focus of studies should now be based on the perspective of “how the patient feels”; hence, we believe that the results of this study, which is based on patient-reported outcomes, are meaningful.
Using integrated multi-omics data analysis to identify 5-gene signature for predicting survival of patients with hepatocellular carcinoma
Authors: Zhang Rulin , Wu Junyi , Zhao Yingying , Xu Xiang , Liu Xiaolei , Wu Jun 
Published: March 2022

Abstract
Due to the poor prognosis for hepatocellular carcinoma (HCC) presently, a systemic analysis supported by the multi-omics data is extremely necessary to search for gene markers for the clinical prognostic prediction of HCC. The data on RNA-seq, single nucleotide polymorphism (SNP), and copy number variation (CNV), etc. were downloaded from TCGA, leading to a final of 367 samples, which were divided into training set and testing set randomly. In the training set, both prognosis-related genes and those with SNP or CNV were screened, which were incorporated for feature selection using the random forest method. The testing and GEO verification sets (N=265) were used to verify the constructed gene-related prognosis model. qPCR was used to detect the expression of 5 genes in clinical specimens. After including genomic variant and prognosis-related genes, we got 78 candidate genes and 5 feature genes (CISH, LHPP, MGMT, PDRG1, and LCAT) eventually through random forest feature selection. The 5-gene signature is an independent prognostic risk factor for HCC patients. In addition, the signature shows good predicting performance and clinical practicality in train- ing set, testing set and external verification set. The results of qPCR based on clinical samples showed that the expression of PDRG1 was increased in colon cancer tissues and the expression of CISH, LHPP, MGMT and LCAT were decreased in colon cancer tissues. We identify the ability of 5-gene signature to serve as an innovative marker of survival prediction for patients with HCC.
PROBLEMATIKA KONTRAK BAKU DALAM AKAD MUDHARABAH DI LEMBAGA PERBANKAN SYARIAH
Authors: Na’im Muhlishotu Jannati 
Published: March 2022

The development of financing in Islamic banks illustrates that this productenjoyed by many people. Financing is one option the community to cooperatewith the banks, with a profit-sharing system. This paper aims to examine theproblematic raw deal in mudharabah in Islamic banking. These problems willhave an impact on the lives of customers, where customers will feel aggrievedover contract made unilaterally. At first these customers want to get capital fortheir business because of the content of the burdensome contracts, selection of customers simply leave or not so do the financing by banks. If the customeraccepts the contract of cooperation, we can be sure the customer is running witha full big responsibility. In addition, the ratio of part of the customer will beless commensurate with the contribution of cooperation that customers provide.
Enrichment and characterization of Anammox bacteria in a non-woven membrane reactor
Authors: Lyu Yuhua , Yan Song , Gong Zheng , Zhang Shoutong 
Published: March 2022

Abstract
An upflow column reactor packed with nonwoven fabric carrier was used to enrich anaerobic ammonium oxidation (Anammox) sludge. After 101 days, the reactor Anammox sludge concentration increased from 470 to 3,118 mg·L−1. In the stable operating stage, the average total nitrogen (TN) volume loading rate was 818.3 mg·L−1, and the maximum removal efficiencies of NH4+-N, NO2−-N and TN were 65.9, 81.2 and 63.8%, respectively. Scanning electron microscopy (SEM) showed that the cultivated sludge was dominated by a mix of short rod-shaped and spherical bacteria, which accumulated to the typical cauliflower-like aggregates assumed to be the Anammox culture. Fluorescence in situ hybridization (FISH) analysis using 16S rRNA showed that the dominant population developed in the reactor when hybridized with both PLA46 and Amx820 gene probes. This indicates that the cultivated biomass may comprise Planctomycetes bacteria. The results of real-time quantitative PCR (qPCR) showed that these bacteria formed 45 to 60% of the total bacteria in the Anammox sludge. The study demonstrated successful detection and enrichment of Anammox bacteria in wastewater.
Therapeutic Mechanism of Xiaoqinglong Decoction against COVID-19
Based on Network Pharmacology and Molecular Docking Technology
Authors: Deng Jing-Min , Li Hai-Li , Zhou Jian-Peng 
Published: March 2022

Background:
A xiaoqinglong decoction (XQLD) has been proven effective in treating
severe coronavirus disease 2019 (COVID-19) cases; however, the mechanism remains unclear.

Objective:
In the current study, we used network pharmacology and molecular docking technology
to identify the effective components, potential targets, and biological pathways of XQLD against
COVID-19.

Methods:
Public databases were searched to determine the putative targets of the active compounds
of XQLD and COVID-19-related targets. STRING and Cytoscape were used to establish
the protein-protein interaction network and drug component, along with the target-pathway network.
The DAVID database was used to enrich the biological functions and signaling pathways.
AutoDock Vina was used for virtual docking.

Results:
We identified 138 active compounds and 259 putative targets of XQLD. Biological network
analysis showed that quercetin, beta-sitosterol, kaempferol, stigmasterol, and luteolin may be
critical ingredients of XQLD, whereas VEGFA, IL-6, MAPK3, CASP3, STAT3, MAPK1,
MAPK8, CASP8, CCL2, and FOS may be candidate drug targets. Enrichment analysis illustrated
that XQLD could function by regulating viral defense, inflammatory response, immune response,
and apoptosis. Molecular docking results showed a high affinity between the critical ingredients
and host cell target proteins.

Conclusion:
This study uncovered the underlying pharmacological mechanism of XQLD against
COVID-19. These findings lay a solid foundation for promoting the development of new drugs
against severe acute respiratory syndrome coronavirus-2 infection and may contribute to the global
fight against the COVID-19 pandemic.
Therapeutic Potential of Superoxide Dismutase Fused with Cell- Penetrating Peptides in Oxidative Stress-Related Diseases
Authors: Jiang Ren-Wang , Wang Xiao-Lu 
Published: March 2022

Abstract:Superoxide dismutase (SOD) is a well-known cellular antioxidant enzyme. However, exogenous SOD cannot be used to protect tissues from oxidative damage due to the low permeability of the cell membrane. Cell-penetrating peptides (CPPs) are a class of short peptides that can cross the cell membrane. Recombinant fusion protein that fuses SOD protein with CPP (CPP-SOD) can cross various tissues and organs as well as the blood-brain barrier. CPP-SODs can relieve severe oxidative damage in various tissues caused by radiation, ischemia, inflammation, and chemotherapy by clearing the reactive oxygen species, reducing the expression of inflammatory factors, and inhibiting NF-κB/MAPK signaling pathways. Therefore, the clinical application of CPP-SODs provides new therapeutic strategies for a variety of oxidative stress-related disorders, such as Parkinson’s disease, diabetes, obesity, cardiac fibrosis, and premature aging.
Discrepancy Between Cognitive Test and Brain Imaging Results in
Alzheimer’s Disease Associated with Diabetes
Authors: Hanyu Haruo , Koyama Yumi , Horita Haruka , Aoki Toshinori , Sato Tomohiko , Kanetaka Hidekazu , Shimizu Soichiro , Hirao Kentaro 
Published: March 2022

Background/Objective::
Although a large number of studies have been performed on the
association between Alzheimer’s disease (AD) and type 2 diabetes mellitus (DM), the underlying
pathophysiology of AD associated with DM has not been fully elucidated to date. We compared cognitive
functions and brain imaging findings between AD patients with and without DM to characterize
the association between cognition and imaging findings in AD patients with DM.

Methods:
Cognitive functions and brain imaging findings, including medial temporal lobe atrophy
analyzed by magnetic resonance imaging, and hypoperfusion in the parietal, posterior cingulate, and
frontal regions analyzed by single-photon emission computed tomography were compared between
126 AD patients without DM ([AD-DM]) and 51 AD patients with DM ([AD+DM]). Factors associated
with cognitive-imaging associations, including education, occupation, leisure activity, comorbidity,
frailty, and other demographics, were analyzed.

Results:
The [AD+DM] group showed significantly more severe cognitive dysfunction than the [ADDM]
group, despite a similar degree of brain imaging abnormalities. Among the factors associated
with cognitive-imaging associations, the level of leisure activity was significantly lower in the
[AD+DM] group than in the [AD-DM] group, but no significant differences in other factors were observed
between the 2 groups.

Conclusion:
The cognitive-imaging discrepancy observed in AD patients with DM may be associated
with their low cognitive reserve, possibly caused by their low amount of leisure activities. Our findings
suggest that lifestyle interventions, including physical, cognitive, and social activities, may reduce cognitive
decline in AD patients with DM.
Antimicrobial Remedies and Emerging Strategies for the Treatment of
Diabetic Foot Ulcers
Authors: Agrawal Yogeeta O. , Husain Muzammil 
Published: March 2022

Background:
Diabetic foot ulcers (DFU) are one of the most serious complications in
diabetic health treatment. The treatment for DFUs is more challenging, especially in individuals
with a weakened immune system. Furthermore, due to developing antibiotic resistance characteristics
among harmful bacteria and fungi, existing antibiotics may not be helpful in combating microbial
infections in the wound site.

Objectives:
This review will focus on the newest advances in antimicrobial treatments, such as
dressings and topical therapies, as well as drugs and debridement methods.

Methods:
The English-language publications published on DFU were collected from a variety of
sources, including Scopus, Web of Science, Bentham Science, Science Direct, and Google Scholar.

Results:
DFU therapy necessitates a multidisciplinary strategy including the use of appropriate diagnostic
instruments, expertise, and experience. This begins with patient education and the use of
new classifications to direct care in order to avoid amputations. To gain a deeper understanding of
the microbiota in DFUs, new diagnostic approaches, such as the 16S ribosomal DNA sequence in
bacteria, should become usable.

Conclusion:
DFU is said to have a polymicrobial nature and, depending on its geographical area,
some distinct characteristics, such as wound characteristics, antibiograms based on local epidemiology,
individualized antimicrobial driven treatment, routine debridement, regular wound examination,
and dressing changes. New biological and molecular therapies that have been shown to enhance
infection prevention, the management of the local inflammatory profile, and the efficiency
of the cicatrizing mechanism often help with the above characteristics.
Sickle Cell Transplantation Evaluation of Long-term and Late Effects Registry (STELLAR) to Compare Long-term Outcomes After Hematopoietic Cell Transplantation to Those in Siblings Without Sickle Cell Disease and in Nontransplanted Individuals With Sickle Cell Disease: Design and Feasibility Study
Authors: Krishnamurti Lakshmanan , Arnold Staci D , Haight Ann , Abraham Allistair , Guilcher Gregory MT , John Tami , Bakshi Nitya , Shenoy Shalini , Syrjala Karen , Martin Paul L , Chaudhury Sonali , Eames Gretchen , Olowoselu Olusola Festus , Hsieh Matthew , De La Fuente Josu , Kasow Kimberly A , Stenger Elizabeth , Mertens Anne , El-Rassi Fuad , Lane Peter , Shaw Bronwen E , Meacham Lillian , Archer David 
Published: March 2022

Background
There are sparse data on the long-term and late effects of hematopoietic cell transplantation (HCT) for sickle cell disease (SCD).

Objective
This study aims to establish an international registry of long-term outcomes post-HCT for SCD and demonstrate the feasibility of recruitment at a single site in the United States.

Methods
The Sickle Cell Transplantation Evaluation of Long-Term and Late Effects Registry (STELLAR) was designed to enroll patients with SCD ≥1 year post-HCT, their siblings without SCD, and nontransplanted controls with SCD to collect web-based participant self-reports of health status and practices by using the Bone Marrow Transplant Survivor Study (BMTSS) surveys, health-related quality of life (HRQOL) using the Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Profile-25 or Pediatric Profile-29 survey, chronic graft-versus-host disease (cGVHD) using the symptom scale survey, daily pain using an electronic pain diary, the economic impact of HCT using the financial hardship survey, sexual function using the PROMIS Sexual Function SexFSv2.0 survey, and economic productivity using the American Time Use Survey (ATUS). We also piloted retrieval of clinical data previously submitted to the Center for International Blood and Marrow Transplant Research (CIBMTR); recorded demographics, height, weight, blood pressure, waist and hip circumferences, timed up and go (TUG) test, and handgrip test; and obtained blood for metabolic screening, gonadal function, fertility potential, and biorepository of plasma, serum, RNA, and DNA.

Results
Of 100 eligible post-HCT patients, we enrolled 72 (72%) participants aged 9-38 (median 17) years. We also enrolled 19 siblings aged 5-32 (median 10) years and 28 nontransplanted controls with SCD aged 4-46 (median 22) years. Of the total 119 participants, 73 (61%) completed 85 sets of surveys and 41 (35%) contributed samples to the biorepository. We completed ATUS interviews of 28 (24%) participants. We successfully piloted retrieval of data submitted to the CIBMTR and expanded recruitment to multiple sites in the United States, Canada, the United Kingdom, and Nigeria.

Conclusions
It is feasible to recruit subjects and conduct study procedures for STELLAR in order to determine the long-term and late effects of HCT for SCD.

International Registered Report Identifier (IRRID)
DERR1-10.2196/36780
Menelusuri Potensi Fraud dalam Jaminan Kesehatan Nasional melalui Rekam Medis di Rumah Sakit
Authors: Sugiarti Ida , Masturoh Imas , Fadly Fery 
Published: March 2022

Latar Belakang: Akibat fraud, BPJS (Badan Penyelenggara Jaminan Sosial Kesehatan) harus membayar klaim lebih besar, sehingga terjadi kerugian negara. Salah satu bentuk fraud yang ditemukan di kelompok provider adalah upcoding. Data koding dan rekaman pelayanan kesehatan dalam rekam medis dapat digunakan sebagai deteksi fraud.Tujuan: Menelusuri potensi fraud dalam rekam medis melalui telusur keakuratan kode diagnosis dan clinical pathway.Metode: Pendekatan kuantitatif kualitatif. Jenis penelitian case study, kasus thypoid. Subjek penelitian ditentukan dengan purposive sampling. Sampel penelitian kuantitatif menggunakan berkas rekam medis. Metode pengumpulan data menggunakan lembar observasi dan indept interview. Analisis data kuantitatif dengan analisis deskriptif dan Analisa data kualitatif dengan analisis konten.Hasil: Dari 87 dokumen, ketidaktepatan kode diagnosis 31,03%, dengan presentase ketidaksesuaian tarif klaim 26,44%. Terdapat berbagai penyebab upcoding diantaranya karena aturan pengkodean yang berbeda antara kode diagnosis berdasarkan ICD 10 dan kode untuk kepentingan klaim yang mengacu pada peraturan dari BPJS yang dituangkan dalam Berita Acara. 91,30% ketidaksesuaian merupakan tarif klaim naik. Ketidaksesuaian clinical pathway paling banyak pada item tes widal dengan presentase 21.84%.Kesimpulan: Upcoding tidak selalu disebut fraud, harus ada unsur kesengajaan untuk mendatangkan keuntungan finansial. Upcoding dapat merubah klaim menjadi lebih tinggi. Keberadaan clinical pathway penting sebagai acuan tindakan pelayanan kesehatan.
Penggunaan Bahasa dalam Ranah Pariwisata; Studi di Kawasan Taman Nasional Bantimurung Bulusaraung Maros, Sulawesi Selatan
Authors: Rijal Andy Samsu 
Published: March 2022

The existence of tourism in the community provides an opportunity for the use of various language domains. The use of language by tour guides in National Park of Bantimurung Bulusaraung, Maros Regency, which is a Bugis-Makassar ethnic community, now used not only the regional language domain, Indonesian language, but also the Makassar Malay language (MML) domain and the foreign language (FL) domain. The use of this language is not only influenced by linguistic aspects but also influenced by non-linguistic aspects such as participant factors, speech situations, speech topics, the speaker's socio-cultural background and speech partners. This article described the forms and variations of language that arise from language contact by guides and tourists. The research method used is a qualitative method with anthropological linguistic approach. Data collection was done by recording and semi-structured interviews with several informants. From the research results found three language choices including single language variation (SLV), language code switching (CS), and code mixing (CM). There were three uses of SL variations, namely Bugis Language (BL), Makassar Malay (MML) and Indonesian Language (I.L) formal varieties. The used of CS from both Bugis to Makassar language (ML) was also found in local tourists (Bugis speakers or Makassar speakers), CS from regional languages (RL) to MML also occurs in interactions between speakers and tourists or speech partners who are not Bugis-Makassar speakers but were the speaker of other regional languages in South Sulawesi. The used of CS from MML to Indonesian language had a formal variety of interactions with domestic tourists. Variations in English Makassar Malay Language as both CS and CM were found in interactions with foreign tourists.
Do Shared Auditors Improve Audit Quality? Evidence from Banking Relationships
Authors: Ton Karen 
Published: March 2022

ABSTRACT
Auditor knowledge is a key element in explaining the supply of audit quality, yet understanding of the drivers of this knowledge in the archival literature is limited. This study uses an archival approach to examine whether the sharing of auditors among firms in banking relationships results in information transfers that improve audit quality. I find that audit quality improves for both borrowers and lenders who share the same auditor office. Specifically, lenders who share an auditor office with their borrowers have more accurate loan-loss provisions, especially lenders with smaller commercial loan portfolios. Borrowers who share an auditor office with their lender are less likely to receive a clean audit opinion just prior to bankruptcy. Overall, these findings are consistent with shared auditors in banking relationships developing client specific knowledge that is transferable across clients and industries.
JEL Classifications: G21; M41; M42.