bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the safety and efficacy of hematopoietic and mesenchymal stem cell transplantation for treatment of T1DM: a systematic review and meta-analysis
Authors: Madani Sedigheh , Amanzadi Mahdiyeh , Aghayan Hamid Reza , Setudeh Aria , Rezaei Negar , Rouhifard Mahtab , Larijani Bagher 
Published: May 2022

AbstractBackgroundStem cell transplantation (SCT) has paved the way for treatment of autoimmune diseases. SCT has been investigated in type 1 diabetes mellitus (T1DM) as an autoimmune-based disorder, but previous studies have not presented a comprehensive view of its effect on treatment of T1DM.MethodologyAfter registration of the present systematic review and meta-analysis in the PROSPERO, a search was done according to the Cochrane guidelines for evaluation of clinical trials to find eligible clinical trials that investigated the effect of SCT on T1DM (based on ADA® diagnostic criteria) from PubMed, Web of science, Scopus, etc, as well as registries of clinical trials from January 1, 2000, to September 31, 2019. A search strategy was designed using MeSH and EM-tree terms. Primary outcome included the changes in the insulin total daily dose (TDD) (U/kg) level, and secondary outcomes included the changes in the HbA1c, c-peptide, and adjusted HbA1c levels. TheQCochrane test andI2statistic were performed to assess the heterogeneity and its severity in primary clinical trials. The Cochrane ROB was used to determine risk of bias, and Cochrane Handbook for Systematic Reviews of Interventions was used in the full text papers. The meta-analysis was accomplished in the STATA software, and the results were shown on their forest plots. Confounders were evaluated by the meta-regression test.ResultsA total of 9452 studies were electronically screened, and 35 papers were included for data extraction. The results of this review study showed that 173 (26.5%) diabetic patients experienced insulin-free period (from 1 to 80 months), and 445 (68%) showed reduction in TDD of insulin after the SCT. Combination of hematopoietic stem cell (HSC) with mesenchymal stem cell (MSC) transplantation were significantly associated with improvement of the TDD (SMD: − 0.586, 95% CI: − 1.204/− 0.509,I2: 0%), HbA1c (SMD: − 0.736, 95% CI: − 1.107/− 0.365,I2: 0%), adjusted HbA1c (SMD: − 2.041, 95% CI: − 2.648/− 1.434,I2: 38.4%), and c-peptide (SMD: 1.917, 95% CI: 0.192/3.641,I2: 92.5%) on month 3 of follow-up, while its association had a growing trend from 3 to 12 months after the transplantation. Considering severe adverse events, HSC transplantation accompanied with conditioning could not be suggested as a safe treatment.ConclusionMost of the clinical trials of SCT in T1DM were single arm. Although meta-analysis illustrated the SCT is associated with T1DM improvement, well-designed randomized clinical trials are needed to clarify its efficacy.RecommendationBased on the results of this meta-analysis, the MSC and its combination with HSC could be considered as “Safe Cell” for SCT in T1DM. Furthermore, to evaluate the SCT efficacy, calculation of insulin TDD (U/kg/day), AUC of c-peptide, and adjusted HbA1c are highly recommended.
Numerical investigation of fractional-order Kersten–Krasil’shchik coupled KdV–mKdV system with Atangana–Baleanu derivative
Authors: Iqbal Naveed , Botmart Thongchai , Mohammed Wael W. , Ali Akbar 
Published: May 2022

AbstractIn this article, we present a fractional Kersten–Krasil’shchik coupled KdV-mKdV nonlinear model associated with newly introduced Atangana–Baleanu derivative of fractional order which uses Mittag-Leffler function as a nonsingular and nonlocal kernel. We investigate the nonlinear behavior of multi-component plasma. For this effective approach, named homotopy perturbation, transformation approach is suggested. This scheme of nonlinear model generally occurs as a characterization of waves in traffic flow, multi-component plasmas, electrodynamics, electromagnetism, shallow water waves, elastic media, etc. The main objective of this study is to provide a new class of methods, which requires not using small variables for finding estimated solution of fractional coupled frameworks and unrealistic factors and eliminate linearization. Analytical simulation represents that the suggested method is effective, accurate, and straightforward to use to a wide range of physical frameworks. This analysis indicates that analytical simulation obtained by the homotopy perturbation transform method is very efficient and precise for evaluation of the nonlinear behavior of the scheme. This result also suggests that the homotopy perturbation transform method is much simpler and easier, more convenient and effective than other available mathematical techniques.
The superficial zone of articular cartilage
Authors: Saito Taku 
Published: May 2022

AbstractThe superficial zone of articular cartilage contributes to smooth joint motion through the production of proteoglycan 4 (PRG4), also known as lubricin. Recent studies indicate novel effects of PRG4 as a signaling molecule, other than a simple extracellular matrix protein. Additionally, the accumulating evidence displays that various molecules and signaling pathways are involved in regulating the superficial zone and PRG4 expression. In addition, Prg4-expressing cells include a progenitor population of articular chondrocytes. Several non-clinical and clinical studies have shown that PRG4 and related molecules are promising candidates for disease-modifying drugs for treating osteoarthritis. Since PRG4 is also expressed in the synovium, tendons, and ligaments, further studies of PRG4-related pathways and PRG4-positive cells may elucidate the mechanisms underlying joint homeostasis.
Diagnostic value of shear wave ultrasound elastography of tibial nerve in patients with diabetic peripheral neuropathy
Authors: Ibrahim Heba R. 
Published: May 2022

Abstract
Background
Diabetic peripheral neuropathy (DPN) is a major complication of Diabetes mellitus. So this study aimed at investigation of the value of tibial nerve stiffness measured by shear wave ultrasound elastography (SWE) for detection of DPN. This case–control study involved 50 patients with DPN, 50 patients with diabetes mellitus but without DPN, and 50 healthy controls. Clinical examination, nerve conduction study of both tibial nerves, high resolution ultrasound and SWE to assess cross sectional area "CSA" of tibial nerves, and tibial nerves mean stiffness, respectively. ROC curve analysis was also performed.

Results
Mean tibial nerve stiffness by SWE was higher in patients with DPN compared to other groups (P value < 0.001). The CSA of the tibial nerve in the DPN group was significantly larger than that in the other groups (P value = 0.01). The cutoff value by ROC curve analysis for tibial nerve stiffness to differentiate patients with DPN and control group was 70.6 kPa (P value < 0.001, 95.4% sensitivity, 94.7% specificity, AUC = 0.963), while 86.5 kPa was the optimal cutoff point to differentiate patients with DPN and other groups with a 94.6% sensitivity, 93.8% specificity, AUC of 0.975 and P value < 0.001. Higher diagnostic accuracy was found when combination of SWE and high resolution US (high resolution US + shear wave; 0.987, P value < 0.001).

Conclusions
Tibial nerve stiffness was increased in patients with DPN. SWE can be used as an effective complementary method in diagnosis of DPN with high sensitivity and accuracy.
Ramsey scheme applied to string theoretical processes
Authors: Wani Salman Sajad , Shabir Arshid , Faizal Mir , Rubab Seemin 
Published: May 2022

Abstract
In this paper, we analyze the evolution of physical quantities due to the interaction of strings with background fields. We will obtain the characteristic function for such a string theoretical process. This will be done by generalizing the Ramsey scheme to world-sheet, and using it to obtain the information about the evolution of quantity in a string theoretical process, without making two-point measurements. We will also use the characteristic function to obtain the average of the difference between the initial and final values of such a quantity. Finally, using the characteristic function, we calculate the Fisher information for the difference of such a quantity.
Tackling multimorbidity: patient characteristics and outcomes from a generic rehabilitation programme
Authors: Cowie Aynsley , McKay Janet , Holt Jane , Baylis Moray 
Published: May 2022

Background/Aims This service evaluation analyses the first 3 years of a novel 10-week generic rehabilitation programme, describing the cohort population assessed at baseline, and examining outcomes generated by programme completion. The programme is part of a wider specialist-generalist health and social care model, based within Ayrshire, Scotland, which has been designed to be a sustainable approach to tackling multimorbidity. Methods Sociodemographic and diagnostic data were obtained for all service users who attended for baseline assessment. Two groups were compared: those who completed the 10-week programme (completers group) and those who did not (assessment+ group). Quality of life data were obtained from the completers group at the start and end of the 10-week programme, while emergency bed days accrued in the 12 months pre- and post-referral were recorded from both groups. Results Over 3 years, n=978 service users attended for assessment (mean age 66.3 years; male:female ratio 441:537 [45%:55%]; average of four co-existing conditions). Deprivation was significantly higher for the assessment+ group (P=0.003). The completers group demonstrated significant improvements across various quality of life outcomes (P<0.001), and significantly reduced emergency bed days (P=0.005; P=0.001) following the programme. Conclusions In this generic multimorbidity rehabilitation programme, the baseline population was older adults, comprised slightly more women than men, and who had presented with complex multimorbidity. Deprivation was significantly higher in those who did not complete the programme, and further qualitative and quantitative exploration of this group is required. Completing the programme appeared to significantly improve quality of life and unscheduled care use.
Whole genome sequencing of SARS-CoV2 strains circulating in Iran during five waves of pandemic
Authors: Yavarian Jila , Nejati Ahmad , Salimi Vahid , Shafiei Jandaghi Nazanin Zahra , Sadeghi Kaveh , Abedi Adel , Sharifi Zarchi Ali , Gouya Mohammad Mehdi , Mokhtari-Azad Talat 
Published: May 2022

Purpose
Whole genome sequencing of SARS-CoV2 is important to find useful information about the viral lineages, variants of interests and variants of concern. As there are not enough data about the circulating SARS-CoV2 variants in Iran, we sequenced 54 SARS-CoV2 genomes during the 5 waves of pandemic in Iran.

Methods
After viral RNA extraction from clinical samples collected during the COVID-19 pandemic, next generation sequencing was performed using the Nextseq platform. The sequencing data were analyzed and compared with reference sequences.

Results
During the 1st wave, V and L clades were detected. The second wave was recognized by G, GH and GR clades. Circulating clades during the 3rd wave were GH and GR. In the fourth wave GRY (alpha variant), GK (delta variant) and one GH clade (beta variant) were detected. All viruses in the fifth wave were in clade GK (delta variant). There were different mutations in all parts of the genomes but Spike-D614G, NSP12-P323L, N-R203K and N-G204R were the most frequent mutants in these studied viruses.

Conclusions
These findings display the significance of SARS-CoV2 monitoring to help on time detection of possible variants for pandemic control and vaccination plans.
A SUSTAINABLE APPROACH TO IMPROVEMENT OF CORROSION PROTECTION COATINGS FOR STEEL STRUCTURES
Authors: Soroushian Parviz , Balachandra Anagi , Weerasiri Rankothge , Darsanasiri Nalin , Abdol Nastran 
Published: May 2022

Corrosion is a primary factor compromising the safety and service life of steel structures. Corrosion protection coatings are generally employed for protection of the steel structures that are exposed to different aggressive environments. This research evaluated the use of biobased ion exchangers as a sustainable means of improving corrosion protection coatings.
Two base polymer coatings (vinyl and coal-tar epoxy) were considered. The following types and dosages of biobased ion exchangers were evaluated in these coatings: (i) strong-base ion exchange cellulose in OH, PO4, SiO3, BO3, NO2, SO4 and NO3 forms at 1% by weight of resin; (ii) weak-acid starch citrate ion exchanger in H form at 1 wt.%; and (iii) strong-base ion exchange cellulose in OH form at 2 wt.%. In addition, a strong-base ion exchange resin in OH form was considered at 1 and 2 wt.% as control. Different coating formulations were evaluated based on the outcomes of salt-fog corrosion, moisture resistance, pull-off strength, and abrasion resistance tests. The introduction of certain biobased ion exchangers in protective coatings was found to be an effective means of achieving improved levels of corrosion resistance, adhesion capacity, moisture stability and abrasion resistance.
Impacts of the gradient-index crystalline lens structure on its peripheral optical power profile
Authors: Li Qing , Fang Fengzhou 
Published: May 2022

Abstract
The crystalline lens makes an important contribution to the peripheral refraction of the human eye, which may affect the development and progression of myopia. However, little has been known about the peripheral optical features of the crystalline lens and its impacts on the peripheral ocular refraction. This study aims to investigate the relationship between the structural parameters of the crystalline lens and its peripheral power profile over a wide visual field. The peripheral power profile is defined with respect to the entrance and exit pupil centers along the chief rays. Analysis is performed by three-dimensional ray tracing through the gradient refractive index (GRIN) lens models built from measurement data. It has been found that the vergence of the wavefronts at the entrance and the exit pupil centers of the lens show an approximate linear correlation to each other for each field angle. The exponent parameters of the axial refractive index profile and the axial curvature profile, and the asphericity of the posterior lens surface are found to be the most influential parameters in the peripheral power profiles. The study also shows that there can be significantly different, sometimes unrealistic, power profiles in the homogeneous lens model compared with its corresponding GRIN model with the same external geometry. The theoretical findings on the peripheral lens properties provide a new perspective for both wide-field eye modelling and the design of intraocular lenses to achieve normal peripheral vision.
Multiphase flow, heat and mass transfer modeling during frying of potato: effect of food sample to oil ratio
Authors: Ghaderi Abdurrahman , Dehghannya Jalal , Ghanbarzadeh Babak 
Published: May 2022

Abstract
Sample to oil ratio (SOR) during frying of food products should be carefully determined because it substantially influences oil absorption. A novel computer simulation to model momentum, heat, and mass transfer was developed to investigate the effect of SOR (1/10, 1/15, and 1/20) on velocity, temperature, moisture, and oil distributions during frying of potato strips. The present study was intended to cover missing aspects in scientific literature dealing with potato frying modeling. In addition, one of the major contributions offered by this work regarded the possibility of major effect of SOR on healthiness of products. An increase in water vapor production at a higher SOR played a significant role in increasing oil velocity. While the SOR did not have a substantial effect on center temperature of potato strips, surface temperature decreased with an increase in SOR. The SOR affected moisture content of the corners of the specimens, whereas it did not significantly affect the center moisture. Simulation of the longitudinal section of potato center showed that oil uptake increased with increasing SOR. The decrease in oil uptake by decreasing SOR was justified by the water vapor production and crust formation. Water vapor acted as a barrier against oil diffusion and had a significant impact on stirring the oil and creating homogeneous temperatures. Overall, this study offered a proper numerical tool to control oil absorption, leading to understanding complex mechanisms during deep-fat frying of foods. It is hoped that the results of this study could head to a further step in developing an optimized deep-fat frying process.
Osteoporosis knowledge and health beliefs among middle-aged men and women in the Southern United States
Authors: Chelf Stacy , Davis Robert E. , Bass Martha A. , Ford M. Allison , Firouzabadi Ali D. , Leo Jonathan T. , Nahar Vinayak K. 
Published: May 2022

Abstract

Context
The most common skeletal disease, osteoporosis, causes bone fragility due to decreased bone mass and bone microarchitecture destruction. The health belief model is often applied to asymptomatic, prevention-related diseases such as osteoporosis. Steps to mitigate the insidious nature of osteoporosis, including education, motivation, and monitoring of bone mineral density, must begin at an earlier age.

Objectives
This study evaluates the knowledge and health beliefs surrounding osteoporosis in a population of males and females 35–50 years old to determine sex-based differences in osteoporosis knowledge and beliefs and to assess the correlation between perceptions and health motivation.

Methods
Participants (81 males, 92 females) completed two questionnaires: the Osteoporosis Knowledge Test and the Osteoporosis Health Belief Scale. Descriptive statistics were performed along with Pearson product-moment correlation analysis to determine the relationships between the variables. Sex-based differences were calculated utilizing independent t-tests.

Results
We discovered a statistically significant negative correlation between the barriers to exercise and health motivation (−0.434, p < 0.001) and a statistically significant positive correlation between the benefits of exercise and health motivation (0.385, p < 0.001). However, there was not a statistically significant correlation between health motivation with the following: the benefits of calcium, susceptibility, and the seriousness of osteoporosis. Between males and females, there was a statistically significant difference in exercise and calcium knowledge, susceptibility, and the benefits of both exercise and calcium (p < 0.05).

Conclusions
Males and females 35–50 years old perceive themselves to have a low susceptibility to osteoporosis. They do not consider osteoporosis a serious disease and have little motivation to mitigate its inception or progression. Their perceptions show that barriers to exercise impact health motivation more than the perceived benefits of exercise.
Design of membrane systems
Authors: Mitkowski Piotr Tomasz , Szaferski Waldemar , Nędzarek Arkadiusz , Sales-Cruz Mauricio 
Published: May 2022

Abstract
Membrane separation systems have been used in process industry since decades; however, their designs are based mainly on experienced-based and use of trial-and-error approach, especially in case of membrane selection. This chapter reviews recent advancements in the design of membrane systems used either for separation or creation of mixtures from the perspective of industry 4.0 and data management. Additionally, computer-aided design tools have been reviewed with aim of possible use in the design of membrane separation systems.
On the Invariance Result of Net Neutrality
Authors: Kim Jeong-Yoo 
Published: May 2022

Abstract
In an influential paper, Choi and Kim (2010) established the invariance result that given a fixed network capacity, the average waiting times are identical regardless of net neutrality. In this paper, we argue that their result relies on the assumption that the distribution for content requests per end user is the same regardless of net neutrality. However, if the distribution is determined by the underlying utility maximization problem of users, users expect the contents they request to be transmitted faster if the contents have priority, implying that the request rate for prioritized contents is higher than the request rate for unprioritized contents under net neutrality. If the content request rates per user differ across the two regimes (net neutrality vs. no net neutrality), the invariance result may not be valid. We also discuss social welfare and the investment incentive of the Internet service provider in an extended model with variable content request rates.
CREB Inactivation by HDAC1/PP1γ Contributes to Dopaminergic Neurodegeneration in Parkinson's Disease
Authors: Xu Xiaoyi , He Xin , Zhang Zeyan , Chen Yanyi , Li Junyu , Ma Shanshan , Huang Qiaoying , Li Mingtao 
Published: May 2022

Understanding the pathogenesis of nigral dopaminergic neurodegeneration is critical for developing mechanism-based treatments for Parkinson's disease (PD). In the nigral dopaminergic neurons of postmortem human PD brains, we found that CREB, a well-recognized pro-survival transcription factor in neurons, was inactivated by dephosphorylation at Ser133. CREB dephosphorylation correlated with decreased expression of NURR1, one of its target genes crucial for dopaminergic neuron survival, confirming that CREB function was impaired in nigral dopaminergic neurons in PD. An MPTP mouse model was used to further elucidate the mechanism underlying CREB dephosphorylation. Protein phosphatase 1γ (PP1γ), which dephosphorylates CREB, was constitutively associated with histone deacetylase 1 (HDAC1). HDAC1 promotes CREB Ser133 dephosphorylation via a stable interaction with PP1γ. We found that CREB interacted with the HDAC1/PP1γ complex during dopaminergic neurodegeneration. Importantly, increased CREB/HDAC1 interaction occurred in the nigral dopaminergic neurons of PD patients as demonstrated using a proximity ligation assay. Disrupting CREB/HDAC1 interaction via either overexpression of GAL4 M1, a CREB mutant, or administration of trichostatin A, a pan-HDAC inhibitor, restored the expression levels of phospho-CREB (Ser133) and NURR1, and protected nigral dopaminergic neurons in the MPTP-treated mouse brain. Collectively, our results demonstrated that HDAC1/PP1γ-mediated CREB inactivation contributed to dopaminergic neuronal degeneration. Disruption of CREB/HDAC1 interaction has the potential to be a new approach for PD therapy.SIGNIFICANCE STATEMENTParkinson's disease (PD) is the most common movement disorder attributed to the progressive loss of dopaminergic neurons in the substantia nigra. Understanding the pathogenesis of nigral dopaminergic neurodegeneration is critical for developing mechanism-based treatments for PD. We found in nigral dopaminergic neurons of postmortem human PD brains that CREB, a well-recognized pro-survival transcription factor in neurons, was inactivated by dephosphorylation at Ser133. HDAC1, constitutively associated with PP1γ, interacted with CREB to mediate its dephosphorylation during dopaminergic neurodegeneration. Disrupting CREB/HDAC1 interaction restored CREB activity and protected nigral dopaminergic neurons in the MPTP mouse brains. This work suggests that disruption of the CREB/HDAC1 interaction to restore CREB activity may be a potential therapeutic approach in PD.