bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable replacement of EDTA–Biojarosite for commercial iron in the Fenton's and UV–Fenton's degradation of Rhowedamine B – a process optimization using Box–Behnken method
Authors: S Bhaskar , Rashmishree K. N. , Manu B. , Sreenivasa M. Y. 
Published: October 2022

Abstract
Biojarosite as a replacement for commercial iron catalyst in the oxidative degradation of the dye Rhodamine B was confirmed and established. Investigations on the oxidative degradation by Fenton's oxidation and UV–Fenton's oxidation with EDTA at neutral pH were conducted and degradation of target compound was evaluated. UV–Fenton's oxidation was shown to be efficient over Fenton's oxidation in the degradation of Rhodamine B with removal efficiency of 90.0%. Design of Experiments was performed with Box–Behnken design. Investigation was conducted for the predicted values separately for both Fenton's oxidation and UV–Fenton's oxidation and the Rhodamine B removal was taken as response. Variable parameters biojarosite, H2O2 dosage and EDTA were optimized in the range of 0.1–1 g/L, 2.94–29.4 mM and 10–100 mM, respectively. A quadratic regression model is fitted for both Fenton's and UV–Fenton's oxidation. Analysis of variance (ANOVA) is performed and model fit is discussed.
Therapeutic Potential of Genistein: Preclinical Studies, Clinical
Evidence, and Nanotechnology Application
Authors: Coutinho Ana J. , Pinheiro Marina , Neves Ana R. , Pinto Madalena M.M. 
Published: October 2022

Abstract:
Genistein (4’,5,7-trihydroxyisoflavone) is a natural plant-derived phytoestrogen
that can be found, for example, in soybean seeds. Genistein is present mainly in the
human diet and is a common precursor in the antimicrobial phytoalexins biosynthesis
and phytoanticipins in vegetables. The interest in genistein has increased due to its pharmacological
effects, including anti-cancer activity, neuroprotective effects, cardiovascular
protection, anti-inflammatory effects, antioxidant activity, and prevention of obesity.
The most challenging issue for improving genistein is its low oral bioavailability, which
has led to many animal and human pharmacokinetic studies and numerous clinical trials.
Several drug delivery systems have been developed to protect and stabilize genistein to
overcome the challenge of low bioavailability. This work concerns a revision of the literature
reporting nano and microformulations for genistein encapsulation, including lipid
nanoparticles, liposomes, tocotrienol-rich nanoemulsions, polymeric nanoparticles, dextran
complexes, chitosan complexes, and Fe3O4 nanoparticles with carboxymethylated
chitosan. Regarding the enormous potential of genistein, several clinical trials and marketed
formulations can be found in the market.
Nanotechnology for Targeted Drug Delivery to Treat Osteoporosis
Authors: Nagpal Manju , Kaur Malkiet , Aggarwal Geeta 
Published: October 2022

Abstract:
Bone diseases such as rheumatoid arthritis, Paget's disease, and osteoporosis cause mor-tality and mobility limits. Nanomedicine and nano delivery systems have been utilised to deliver ac-tive drug moiety to the precisely targeted site in a controlled manner, and it serves as a means of di-agnostic tools. The utilisation of nanomedicine is expanding vigorously for assured targeting and efficient drug delivery. Nanotechnology offers various advantages, such as site-specific targeting, precise drug release kinetics, and improved bone mineral density. Recent medications available for osteoporosis are not viable due to the adverse effects associated with them and low patient compli-ance. There is an urgent need to develop biocompatible and appropriate drug delivery nanocarriers such as nanoparticles, liposomes, hydrogels, dendrimers, micelles, mesoporous particles, etc. These carriers enhance drug delivery and therapeutic effectiveness in bone tissues. The use of nanotech-nology is also associated with toxicity. This article presents the review of various reports on nanocarrier systems and biologics for the treatment of osteoporosis. It aims to provide researchers with a clue for inventing a new drug delivery system with site-specific targeting for the treatment of osteoporosis.
Chemotherapeutic Effects of Boswellic Acid Against Human Glioblastoma
Multiform: A Comprehensive Review
Authors: Ebrahimpour-Koujan Soraiya , Khajebishak Yaser , Roudini Kamran , Baziar Nima , Shabani Samaneh , Payahoo Laleh 
Published: October 2022

Background:
Glioblastoma multiform (GBM) is a malignant subgroup of gliomas. Due to
the natural resistance of GBM cells to radio-and chemotherapy usually, recurrence occurs 6-9 months
after diagnosis.

Objective:
This paper reviewed the beneficial effects of Boswellic acid (BA) in adjacent therapy for
GBM, based on its possible molecular mechanisms.

Methods:
In this review paper, all papers indexed in scientific databases, including PubMed, Scopus,
Embase, Google Scholar, and Elsevier were searched during 2000 - 2021 using apoptosis, Boswellic
acid, cancer, glioblastoma multiform, inflammation, oxidative stress as keywords.

Results:
The most important compounds of BAs are alpha-boswellic acid, beta- boswellic acid, acetylbeta-
boswellic acid, acetyl-alpha- boswellic acid, and 11-keto-beta- boswellic acid (KBA). Antiinflammation,
reduction of skin irritation, anti-tumor, anti-cancer, anxiolytic, and anti-phlogistic are
the main properties of BAs. Boswellic acid is recognized as a chemopreventive agent. Boswellic acid
exerts its effects mainly via various mechanisms such as induction of apoptosis and cytotoxic effects
on malignant cells, activation of caspases, up-regulation of genes expression with potential antiapoptotic
and pro-survival properties, inhibition the signaling and activity pathway of nuclear factorkappa
B (NF-κB) and enhancing poly (ADP)-ribose polymerase (PARP) cleavage. Boswellic acid
inhibits the signaling pathway of 5 and 12-lipoxygenase (5, 12 LOX), and cyclooxygenase-2 (COX-2),
which are considered triggers in the production of inflammatory cytokines such as tumor necrosis
factor (TNF-α), and interleukin-1β (IL-1β).

Conclusion:
Future clinical trials are needed to identify the interaction between Boswellic acid and the
severity of GBM and to define the safe dose and effective duration of supplementation.
Fluid shear stress on the endothelium of the carotid artery wall and coronary artery calcinosis in patients with arterial hypertension
Authors: Lobanova N. Iu. , Chicherina E. N. , Malchikova S. V. , Maksimchuk-Kolobova N. S. 
Published: October 2022

Objective: to study the interconditionality of changes in the fluid shear stress on the endothelium (FSE) of the common carotid artery (CCA) wall which is intact from atherosclerosis with the value of the Cardiac Calcium Score (CCS) among patients with e arterial hypertension (AH).Materials and methods: the study included 99 patients with AH, 52 of them had atherosclerotic lesions of the brachiocephalic arteries (BCA). The ultrasound investigation of the carotid arteries with the determination of FSE in the intact area of the CCA, multispiral computed tomography of the coronary arteries with the determination of CCS were performed to all patients.Results: the prevalence of BCA atherosclerotic lesion in the study was 53%. The mean value of FSE for patients with AH and BCA atherosclerosis (group 1) were 660.7 (185.6) c-1, for patients with AH without its (group 2) — 735.8 (149.8) c-1, p = 0.009. The parameters of the lipid spectrum in patients of both groups were comparable. Мedian value of CCS in patients with atherosclerotic lesions of the BCA were statistically significantly higher (15.00 (0.00; 178.00),) compared with patients of the group 2 (0.00 (0.00; 171.00), at p = 0.001. The chances of detecting coronary artery calcification among patients of group 1 are in 2 times higher (OR = 2.25, 95% CI: 1.58-8.33) than among patients of group 2. Low FSE values correlated with male gender (rs = 0.40 (95% CI: 0.22; 0.55) p <0.001) and increasing of CCS (rs = -0.23 (95% CI: -0.41; -0.04) p = 0.022).Conclusions: the prevalence of atherosclerotic lesions of the BCA among patients with AH without a history of symptomatic diseases associated with atherosclerosis was 53%. In the group of patients with AH and atherosclerotic lesions of the BCA, median values of CCS were significantly higher, and coronary artery lesions were detected significantly more often (OR = 2.25, 95% CI: 1.58-8.33) than among patients with AH and intact BCA. The mean value of FSE for patients with AH and BCA atherosclerosis were statistically significantly lower than for patients with AH without it and amounted to 660.7 (185.6) c-1 and 735.8 (149.8) c-1, respectively, p = 0.009. Low FSE values correlated with male gender and increasing of CCS
Clinical and epidemiological features of multiple sclerosis in Republic of Ingushetia
Authors: Goncharova Z. A. , Uzhakhov R. M. , Megeryan V. A. 
Published: October 2022

Objective: to study clinical and epidemiological features and risk factors in patients with multiple sclerosis (MS) living in Rostov region and Republic of Ingushetia (RI)Materials and methods: we examined 87 patients with definite multiple sclerosis. We evaluated neurological deficiency and the specificity of MS course. We have also studied serum concentration of vitamin D3 metabolite — 25(ОН)D3 by ELISA method.Results: the prevalence of NS in RI was 16,9 cases for 100 thousand of the population as of 1.01.2022. Risk fаctors of MS dеvеlopment were cоntаct with pеtrоl, оil prоducts аnd pаints аt аgу оvуr 15 yеаrs оld, cоntаct with аnimаls аt аgе bеfоrе 15 yеаrs оld, a surgicаl intеrvеntiоn, sеvеrе cаriеs аt аgе оvеr 15 yеаrs оld, heаd injury at аny аgе, tоnsillitis, meаslеs, rubеllа оccurrеd аt аgе bеfоrе 7 yеаrs оld аnd hеrpеtic infеctiоn аt аny аgе, thе diffеrеncеs wеrе stаtisticаlly signifiаant. In fеmаlе MS pаtiеnts wе оbsеrvеd highеr pаrаmеtеrs of rеlаpsе frеquеncy аnd MS prоgrеssiоn sрееd, the diffеrеnсеs wеrе stаtisticаlly significаnt. Ассоrding tо thе cоmpаrisоn оf sеrum vitаmin D cоncеntrаtion wе rеvеаlеd a stаtisticаlly rеliаblе dеcrеasе of sеrum vitamin D lеvеl in male MS patients living in RI compared to the control group.Conclusions: the regions of Republic of Ingushetia belong to the areas with low and medium multiple sclerosis development risk. The external factors of MS development risk confirm the multifactor nature of the disease. The decrease of serum vitamin D concentration is one of the main modifiable MS risk factors.
Peran Digital Humanities dalam Upaya Regenerasi Sumber Daya Manusia untuk Mewujudkan Pembangunan Pertanian Berkelanjutan
Authors: Hariadi Sunarru Samsi , Handayani Ari Widya , Dewi Fortuna Puri Eka 
Published: October 2022

Digital humanities is a meeting point between the humanities and the technological sciences with the aim of studying the use of digital tools in aspects of the humanities and how the humanities affect technology. Regarding the development of digital humanities and sustainable agricultural problems, this research is focused on looking at the interest of young people working in agriculture. The purpose of this study is to find out: how the role of digital media (digital humanities) affects the interest of youth working in agriculture so that it can be realized the regeneration of agricultural human resources, what factors affect the interest of youth to work in agriculture, predicting the younger generation who will work in agriculture as an effort to regenerate in agriculture. The study was conducted in Klaten and Temanggung districts with 106 small samples of youth taken at random. To predict the younger generation who will work in agriculture using qualitative and quantitative statistical path analysis. The results stated that youth's interest in working in agriculture is influenced by youth attitudes towards the agricultural sector, social media utilization, self-efficacy, and the role of parents. The use of social media affects the attitude of youth in agriculture and youth self-efficacy. Efforts that can be made to increase the interest of youth working in agriculture include strengthening self-efficacy and attitudes in agriculture by optimizing the role of parents and the use of social media to get information in agriculture.
A scoping review of preprocessing methods for unstructured text data to assess data quality
Authors: Nesca Marcello , Katz Alan , Leung Carson , Lix Lisa 
Published: October 2022

Introduction
Unstructured text data (UTD) are increasingly found in many databases that were never intended to be used for research, including electronic medical record (EMR) databases. Data quality can impact the usefulness of UTD for research. UTD are typically prepared for analysis (i.e., preprocessed) and analyzed using natural language processing (NLP) techniques. Different NLP methods are used to preprocess UTD and may affect data quality.

Objective
Our objective was to systematically document current research and practices about NLP preprocessing methods to describe or improve the quality of UTD, including UTD found in EMR databases.

Methods
A scoping review was undertaken of peer-reviewed studies published between December 2002 and January 2021. Scopus, Web of Science, ProQuest, and EBSCOhost were searched for literature relevant to the study objective. Information extracted from the studies included article characteristics (i.e., year of publication, journal discipline), data characteristics, types of preprocessing methods, and data quality topics. Study data were presented using a narrative synthesis.

Results
A total of 41 articles were included in the scoping review; over 50% were published between 2016 and 2021. Almost 20% of the articles were published in health science journals. Common preprocessing methods included removal of extraneous text elements such as stop words, punctuation, and numbers, word tokenization, and parts of speech tagging. Data quality topics for articles about EMR data included misspelled words, security (i.e., de-identification), word variability, sources of noise, quality of annotations, and ambiguity of abbreviations.

Conclusions
Multiple NLP techniques have been proposed to preprocess UTD, with some differences in techniques applied to EMR data. There are similarities in the data quality dimensions used to characterize structured data and UTD. While a few general-purpose measures of data quality that do not require external data; most of these focus on the measurement of noise.
Analysis of technical statistical indexes of college tennis players under the win-lose regression function equation
Authors: Meng Ming , Lou Yulan , Zhang Hongjie 
Published: October 2022

Abstract
In order to study whether the athletes' special physical fitness and competition load reflect the inherent attributes of sports, this paper puts forward the research on the characteristics of sports, special physical fitness and competition load, and takes the college tennis players in a province as the object. Using the methods of literature, video analysis, experiment, investigation and mathematical statistics, this paper discusses the basic connotation of special physical fitness and competition load, and preliminarily establishes the evaluation index system of special physical fitness and competition load. This paper objectively evaluates the special physical fitness and competition load level of college tennis players in Jiangsu Province, provides the basis for the training and competition of college tennis players, and has certain value and significance for enriching and expanding the tennis training theory. The main conclusions are as follows: calculated from the experimental results, the blood lactic acid level of athletes from the beginning of the competition to the end of the competition is 4.77 + 1.62 mmol / L for men and 4.11 + 2.13 mmol / L for women, which is 2-3 times that of quiet. The change of blood lactic acid is related to the energy system used during exercise, and also reflects the metabolic rate of muscle fibers.
Optimization System of Strength and Flexibility Training in Aerobics Course Based on Lagrangian Mathematical Equation
Authors: Han Jianghua 
Published: October 2022

Abstract
In this paper, the Lagrangian mathematical equation is used to construct a feature extraction model for the flexibility of aerobics athletes. At the same time, this paper uses machine vision to identify and extract feature points of aerobics movements. This paper realizes image feature recognition through multi-dimensional pixel information decomposition. At the same time, we realize the radian trajectory positioning of the aerobics action image based on the Lagrangian equation. The experimental research shows that the algorithm proposed in this paper has higher accuracy and better localization performance when recognizing the radian trajectory of aerobics movements. The algorithm improves the optimization and correction ability of aerobics movements.
Иерархия сакральных пространств Храма Девы Марии в Судакской крепости
Authors: Гусельников Тимур Андреевич 
Published: October 2022

Так называемый «Храм Девы Марии» в Судакской крепости, открытый в ходе экспедиции И.А. Баранова в 1981 г., остаётся малоизученным памятником западной церковной архитектуры в Крыму. Планировка здания, не характерная для греческих храмов, и найденная в нефе надгробная плита с латинской надписью позволяли однозначно атрибутировать здание как римско-католический храм. Сопоставление архитектуры храма Девы Марии с образцами итальянских храмов нищенствующих орденов позволяет говорить о том, что храм воспроизводит в упрощённом виде принципы францисканской и доминиканской архитектуры. Прямоугольная апсида, наличие трёх входов в здание храма в западной, центральной и восточной его части указывают на характерное для нищенствующих орденов трёхчастное деление храма. Поскольку подавляющее большинство клира на территории Крыма и Золотой Орды в XIII–XV вв. составляли монашествующие нищенствующих орденов, приверженность заказчиков принципам, заимствованным из итальянской практики, выглядит закономерной.
Penerapan Teknik Partisi Langkah Kuda Papan Catur pada Pelabelan Super (a,d)-P_2 (▷) ̇ H-Antimagic Total Covering Sebarang Dua Graf dan Aplikasinya
Authors: Rahmatillah A H , Agustin I H , Dafik Dafik 
Published: October 2022

Let be a finite collection of simple, nontrivial and undirected graphs. A graph is as antimagic total covering if there is bijectif function for every subgraph in which isomorfic to and the total weight, form arithmetic sequence , in which a,b are integers and n is a number of graph cover of which the result of total comb product operation. A antimagic total covering is as "super" if smallest label is used for vertex labelling. The way for labelling a graph this time, using a knight move partition techniques application. The graph use total comb product operation . Take a copy of and a number of , then put the copy of -sequence in graph vertex to -sequence vertex of and put the copy of -sequence in graft edge to -sequence edge of is definition of total comb product. In this article, will be investigated about Knight Move Partition Techniques Application in Labelling Super Antimagic Total Covering for Any Two Graphs and Its Application (in Constructing Ciphertext).
AKUNTANSI SEDERHANA BAGI PERUSAHAAN KECIL OLAHAN LELE ALUMNI SEKOLAH KEWIRAUSAHAAN BINA AMANAH CORDOVA
Authors: Murwaningsari Etty , Darmawati Deni , Sofie Sofie , Rachmawati Sistya 
Published: October 2022

Abstrak
Tujuan Pelaksanaan kegiatan PKM membantu pemilik usaha kecil olahan lele untuk memberikan pengetahuan dan pemahaman konsep akuntansi sederhana. Pokok bahasan dalam kegiatan PKM meliputi : 1. Pemahan siklus akuntansi 2. Pendampingan praktik klasifikasi transaksi, membuat catatan kas, membuat jurnal transaksi,3. Kegiatan PKM ini diprogramkan sebagai kegiatan yang berkelanjutan, sehingga pada akhir pendampingan diharapkan peserta akan mampu memahami tentang konsep serta mampu melakukan praktik akuntansi sederhana dalam pencatatan keuangan usahanya. Metode yang digunakan dalam pelaksanan PKM adalah penyuluhan, pelatihan dan diusulkan untuk pendampingan melalui presentasi materi oleh tim pengabdian masyarakat. Dilakukan diskusi dengan peserta dengan dipandu oleh moderator secara hybrid tatap muka langsung dan melaluli zoom. Umpan balik dilakukan dengan kuesioner.. Hasil evaluasi pelaksanaan PKM baik pada saat tatap muka dan melalui kuesioner menunjukan bahwa peserta PKM menyatakan puas dengan kegiatan, dan tujuan PKM tercapai dimana peserta merasa Akuntansi sederhana. Dan peserta PKM mampu menerapkan praktik mengklasifikasi transaksi, membuat jurnal, serta membuat catatan kas.
Kata kunci: Akuntansi Sederhana, Siklus Akuntansi, Jurnal Pencatatan, Catatan Kas
Professional competition as a significant resource for improving pedagogical skills
Authors: Kamerilova G. S. , Prokhorova I. V. 
Published: October 2022

Introduction. The subject of the study in this article is a theoretical understanding of the role of professional competitions to ensure the safety of children on the roads in the development of pedagogical skills of educational workers. It is argued that the competitive participation of creative teachers demonstrating the best integration practices serves as confirmation of the continuity of pedagogical education, its qualitative progress. A model of improving pedagogical skills in the field of child traffic safety based on the ideas of axiology, integration, communicativity in competitive professional activities is justified. Its leading functions and stages are defined. Scientific reasoning is based on the results of the examination of inter-subject road safety projects presented as part of the All-Russian Pedagogical Festival (Moscow, 2021), conducted by employees of the Department of Human Physiology and Life Safety of Mininsky University.Materials and Methods. The materials were the results of an expert assessment of competitive projects (273) of interdepartmental and integrative training of children in safe behavior on the roads, carried out by teachers of 43 constituent entities of the Russian Federation. Analysis and evaluation of author's projects was carried out on the basis of a system of diagnostic methods, revealed in domestic and foreign works, and formatted within the framework of the Pedagogical Festival. The objective and objectives identified the need for analysis methods, including comparative; generalizations and systematization, forecasting and modeling.Results of the study. Formation of a modern scientific idea of professional competitions as effective means of continuing education and substantiation of the model of improving pedagogical skills in the field of child traffic safety based on the implementation of integration projects in competitive professional activitiesDiscussion and Conclusions. The merits of professional competitions in the understanding by teachers of their own experience and reflection in the direction of further self-realization in the context of new educational strategies have been revealed; it was concluded that it is necessary to model the professional improvement of teachers in the training of children in road safety in the logic of integrative design activities and diverse communicativity.