bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meclofenamic Acid Restores Gefinitib Sensitivity by Downregulating Breast Cancer Resistance Protein and Multidrug Resistance Protein 7 via FTO/m6A-Demethylation/c-Myc in Non-Small Cell Lung Cancer
Authors: Chen Hui , Jia Bin , Zhang Qiang , Zhang Yu 
Published: April 2022

Background and ObjectiveGefitinib (GE) is a first-line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) for patients with advanced non-small cell lung cancer (NSCLC) carrying EGFR activating mutations. However, drug resistance limits the clinical efficacy of gefitinib and ultimately leads to extremely poor clinical benefit. Meclofenamic acid (MA) is a non-steroidal anti-inflammatory drug (NSAID) that relieves moderate and severe pain. In the present study, we aim to determine the MA sensibilization of GE in NSCLC.MethodsMTT assay was conducted to determine the synergistic effect of MA with GE in GE-sensitive and -resistant cell lines based on the Chou–Talalay method. The Annexin V-PI flow cytometry analysis was conducted to evaluate apoptosis. Western blot assay was used to detect alterations of EGFR downstream molecules. Tritium-labeled GE accumulation analysis was used to determine the efflux activity of GE. Dot blot assays were conducted to determine m6A levels after the MA and GE co-administration. Western blot evaluated the expression of FTO, c-Myc, MRP7, BCRP, and apoptotic proteins.ResultsMA showed a significant synergistic effect with GE in GE-resistant NSCLC cells; co-administration of MA with GE induced caspase-related apoptosis in resistant NSCLC cells. Moreover, EGFR downstream molecules, including Akt and MAPKs pathways, were significantly inhibited by the MA-GE combination. Short-term incubation of MA did not alter the efflux of GE; however, after incubation for 24 h, the accumulation of tritium-labeled GE significantly increased. A mechanism study showed that co-administration of MA and GE significantly downregulated BCRP and MRP7 expression in GE-resistant cells; increased N6-methylation was also observed after co-administration. The FTO/c-Myc was determined as target pathways on MA and GE co-administration mechanisms.ConclusionOur findings provide novel therapeutic approaches for GE-resistant NSCLC by combination use with MA through FTO-mediated N6-demethylation.
Association of Social Determinants of Health With Rapid Response Events: A Retrospective Cohort Trial in a Large Pediatric Academic Hospital System
Authors: Lawson Nikki R. , Acorda Darlene , Guffey Danielle , Bracken Julie , Bavare Aarti , Checchia Paul , Afonso Natasha S. 
Published: April 2022

BackgroundSocial determinants of health (SDH) are known to impact hospital and intensive care unit (ICU) outcomes. Little is known about the association between SDH and pediatric rapid response (RR) events and understanding this impact will help guide future interventions aimed to eliminate health disparities in the inpatient setting.ObjectivesThe primary objective of this study is to describe the association between SDH and RR utilization (number of RR events, time to RR event, shift of event and caller). The secondary objective is to determine if SDH can predict hospital length of stay (LOS), ICU transfer, critical deterioration (CD), and mortality.MethodsA retrospective cohort study was conducted. We reviewed all RR events from 2016 to 2019 at a large, academic, pediatric hospital system including a level 1 trauma center and two satellite community campuses. All hospitalized patients up to age 25 who had a RR event during their index hospitalization were included. Exposure variables included age, gender, race/ethnicity, language, income, insurance status, chronic disease status, and repeat RR event. The primary outcome variables were hospital LOS, ICU transfer, CD, and mortality. The odds of mortality, CD events and ICU transfer were assessed using unadjusted and multivariable logistic regression. Associations with hospital LOS were assessed with unadjusted and multivariable quantile regression.ResultsFour thousand five hundred and sixty-eight RR events occurred from 3,690 unique admissions and 3301 unique patients, and the cohort was reduced to the index admission. The cohort was largely representative of the population served by the hospital system and varied according to race and ethnicity. There was no variation by race/ethnicity in the number of RR events or the shift in which RR events occurred. Attending physicians initiated RR calls more for event for non-Hispanic patients of mixed or other race (31.6% of events), and fellows and residents were more likely to be the callers for Hispanic patients (29.7% of events, p = 0.002). Families who are non-English speaking are also less likely to activate the RR system (12% of total RR events, p = 0.048). LOS was longest for patients speaking languages other than Spanish or English and CD was more common in patients with government insurance. In adjusted logistic regression, Hispanic patients had 2.5 times the odds of mortality (95% CI: 1.43–4.53, p = 0.002) compared with non-Hispanic white patients.ConclusionDisparities exist in access to and within the inpatient management of pediatric patients. Our results suggest that interventions to address disparities should focus on Hispanic patients and non-English speaking patients to improve inpatient health equity. More research is needed to understand and address the mortality outcomes in Hispanic children compared to other groups.
Biomarkers of PEGylated Liposomal Doxorubicin-Induced Hypersensitivity Reaction in Breast Cancer Patients Based on Metabolomics
Authors: Zhuang Wei , Lai Xiuping , Mai Qingxiu , Ye Suiwen , Chen Junyi , Liu Yanqiong , Wang Jingshu , Li Siming , Huang Yanqing , Qin Tao , Hu Hai , Wu Junyan , Yao Herui 
Published: April 2022

This study aimed to analyze and discuss the biomarkers of PEGylated liposomal doxorubicin (PLD) injection-induced hypersensitivity reactions (HSRs) in advanced breast cancer patients. Fourteen patients from Sun Yat-sen Memorial Hospital were included in the study between April 15th, 2020 and April 14th, 2021. Patient plasma was collected 30 min before PLD injection. HSRs were found to occur in a total of 9 patients (64.3%). No association was found between HSRs and various patient characteristics such as age, body surface area, anthracycline treatment history, IgE, and complement 3 and 4 (p &gt; 0.05). Non-targeted metabolomics analysis of patient plasma was performed, and several metabolites showed significant association with HSRs. In particular, l-histidine (fold change = 91.5, p = 0.01) showed significantly higher levels in the immediate HSR group, while myristicin (fold change = 0.218, p = 0.003), urocanic acid (fold change = 0.193, p = 0.007), and d-aldose (fold change = 0.343, p = 0.003) showed significantly lower levels in the same group. In vivo experiments showed that exogenous histidine aggravated HSRs and increased IgE plasma levels in rats following the injection of PLD. Histidine can be decarboxylated to histamine by histidine decarboxylase. Histidine decarboxylase inhibitor 4-bromo-3-hydroxybenzoic acid improved symptoms and IgE levels in vivo. These findings suggested that l-histidine can be a potential biomarker for PLD-induced HSR. Moreover, an antihistamine drug, histidine decarboxylase inhibitor, or dietary histidine management could be used as potential preventive measures. Furthermore, metabolomics research could serve as a powerful method to explore biomarkers or uncover mechanisms of drug side effects.
Pharmacokinetics, Safety and Pharmacokinetics/Pharmacodynamics Analysis of Omadacycline in Chinese Healthy Subjects
Authors: Yang Haijing , Huang Zhiwei , Chen Yuancheng , Zhu Yusong , Cao Guoying , Wang Jingjing , Guo Yan , Yu Jicheng , Wu Jufang , Liu Lichuan , Deng Jun , Liu Jing , Reinhart Harald , Zhang Jing , Wu Xiaojie 
Published: April 2022

Objective: Omadacycline is a new type of aminomethylcycline antibiotic, having a broad antibacterial spectrum. But the pharmacokinetic characteristics and safety profile of the Chinese population remain unknown. It is also unclear whether the US-approved treatment regimen is applicable for the Chinese population.Methods: In a randomized, double-blinded, placebo-controlled dose-escalated trial, the pharmacokinetics of omadacycline was evaluated by a non-compartmental and compartmental model. Monte Carlo simulations were performed using the pharmacokinetic data from the Chinese population to evaluate the probability of target attainment (PTA) and the cumulative fraction of response (CFR) of the US FDA-approved dose regimen.Results: The three-compartment model successfully described the rapid distribution and slow elimination of omadacycline after the intravenous infusion (i.v.). The double-peak concentration-time curve of the oral absorption (p.o.) was explained by the two-compartment model with two absorption compartments. The steady-state AUC of 100 mg omadacycline i.v. and 300 mg omadacycline p. o. were 12.1 and 19.4 mg h/L, respectively. Pharmacokinetics/pharmacodynamics (PK/PD) analysis showed that the omadacycline dosing regimen with a loading dose (200 mg i.v. q24 h, 100 mg i.v. q12 h, 450 mg p. o. q24 h × 2 days or 300 mg p. o. q12 h) and maintenance dose (100 mg i.v. q24 h or 300 mg p. o. q24 h) could cover the main pathogens of the indications acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP): Staphylococcus aureus and Streptococcus pneumoniae. Also, omadacycline had showed a good safety profile in the Chinese population.Conclusions: With the evidence provided, omadacycline could be a novel treatment option to Chinese patients with ABSSSI and CABP.
Arthroscopic Treatment of Popliteus Tendinitis Using the Accessory Portal
Authors: Chen B. , Liu H. K. , Wang H. 
Published: April 2022

IntroductionThis study aimed to evaluate the effect of arthroscopic treatment of popliteus tendinitis via an auxiliary extreme lateral approach and to investigate the pathogenesis and treatment of popliteus tendinitis.Materials and MethodsFrom 2016 to 2020, arthroscopic popliteus tendon ablation was performed in 15 patients (15 knees) with popliteus tendinitis via an auxiliary extreme lateral approach. Clinical outcomes were assessed using the Lysholm knee scoring scale, the Tegner score, the International Knee Documentation Committee (IKDC) score and the visual analogue scale (VAS) pain score at the 24-month follow-up after surgery.ResultsA total of 15 patients (mean age, 51.1 ± 7.1 years) were included. They had a mean body mass index of 23.8 ± 2.1 kg/m2. The minimum follow-up period was 24 months. Comparing the postoperative state to the preoperative state, the mean postoperative Lysholm score, Tegner score, and IKDC score improved significantly from 70.0 ± 5.0, 3.0 ± 0.9, and 62.3 ± 5.5 to 89.3 ± 4.2, 4.6 ± 0.61, and 80.5 ± 4.4, respectively (p &lt; 0.01). The preoperative VAS score for pain improved from 6.4 ± 0.5 to 0.9 ± 0.4 (p &lt; 0.01). No patients were lost to follow-up.ConclusionsFollowing arthroscopic-assisted treatment, all the patients with popliteus tendinitis achieved satisfactory clinical outcomes in terms of pain relief and improved function.Level of EvidenceLevel IV
Prognostic Significance of Pre- to Postoperative Dynamics of Sarcopenia for Patients with Renal Cell Carcinoma Undergoing Laparoscopic Nephrectomy
Authors: Chen Shuqiu , He Ting , Sun Si , Wu Jianping , Xu Bin , Mao Weipu , Chen Ming 
Published: April 2022

BackgroundThe aim of this study was to investigate the prognostic role of the dynamics of sarcopenia in the pre- to postoperative for patients with renal cell carcinoma (RCC) undergoing laparoscopic nephrectomy.MethodsThis study included 261 patients who underwent laparoscopic nephrectomy between 2014 and 2019. The skeletal muscle index (SMI) of the L3 lumbar region was used to assess sarcopenia. The overall population was divided into four groups according to the dynamics of sarcopenia from pre- to postoperative: group 1 (both pre- and postoperative sarcopenia), group 2 (preoperative non-sarcopenia to postoperative sarcopenia), group 3 (preoperative sarcopenia to postoperative non-sarcopenia), and group 4 (both pre- and postoperative non-sarcopenia). The endpoints of the study were overall survival (OS) and cancer-specific survival (CSS).ResultsOf the 261 patients who underwent laparoscopic nephrectomy, 103 (39.5%) had preoperative sarcopenia and 183 (70.1%) had postoperative sarcopenia. Patients with pre- or postoperative sarcopenia had poor survival outcomes. Sarcopenia dynamic was a better predictor of OS (AUC = 0.737) and CSS (AUC = 0.696) in patients with RCC than pre- and postoperative sarcopenia, and patients in group 4 of sarcopenia dynamic had the best OS and CSS. In addition, sarcopenia dynamics was an independent risk factor for OS and CSS, with a 94.5% reduction in OS risk (HR = 0.055, 95% CI 0.007–0.407, p = 0.003) and a 91.9% reduction in CSS risk (HR = 0.081, 95% CI 0.011–0.616, p = 0.015) in the group 4 compared with the group 1.ConclusionOur study is the first to assess the prognostic value of pre- and postoperative sarcopenia dynamics in patients with RCC.
Resident Perceptions of Sustainable Tourism Development in Borobudur Temple Tourist Destination
Authors: Kusherdyana  
Published: April 2022

The resident’s perception of the impact of tourism development is an important factor for the planning, management and development of a tourism destination. A positive perception of the impact of tourism will encourage residents to support and participate in tourism development, on the contrary, a negative perception of the impact of tourism causes residents accusers to be unsupportive and have no desire to participate in tourism development in the region. Therefore, this study aims to analyze the positive and negative perceptions of residents and their influence on the support and participation of sustainable tourism development. Using a qualitative approach, the data is collected by conducting in-depth interviews with residents around Borobudur Temple Tourist Destinations (BTTD) amount of 23. The results showed that residents have a positive perception of tourism development. They are very supportive and have a desire to participate in the development of tourism. The implication for the local government and the manager is to involve the residents more in the planning and development of BTTD.
Keywords: Resident’s Perception; Resident’s support and participation; Sustainable Tourism Development; Borobudur Temple Tourist Destination.
Sistem Terintegrasi untuk Mendeteksi Perubahan Lingkungan dengan Algoritma Frame Difference dan Dynamic - Adaptive Template Matching menggunakan Raspberry Pi dan Virtual Private Network (VPN)
Authors: Wibowo Ardianto , Zul Muhammad Ihsan , Fadly Ridha M Arif , Zain M Mahrus 
Published: April 2022

Pencurian rumah kosong serta maraknya parkir liar merupakan permasalahan yang banyak terjadi di masyarakat, sehingga menimbulkan keresahan. Untuk itu, diperlukan sebuah solusi yang bisa memberikan alarm / notifikasi secara otomatis apabila terjadi kondisi tersebut kepada pengguna terdaftar. Penelitian ini mengembangkan sebuah sistem terintegrasi yang mempunyai kemampuan mendeteksi adanya perubahan kondisi lingkungan, seperti terjadinya parkir liar ataupun adanya orang asingÂ di dalam rumah, melalui pemantauan kamera IP yang terhubung. Citra yang ditangkap melalui Kamera IP diolah menggunakan algoritma Frame Difference, untuk selanjutnya diputuskan apakah termasuk sebuah kondisi lingkungan berubah ataupun tidak. Dibandingkan dengan Kamera IP konvensional ataupun Kamera IP yang didalamnya sudah terdapat fitur motion detection, sistem hasil penelitian ini mempunyai keunggulan dari sisi fleksibilitas bentuk notifikasi serta fleksibilitas koneksi internet.
Sistem Rekomendasi Penerima Zakat Untuk Mustahiq Dengan Metode Simple Additive Weighting (SAW)
Authors: Sibarani Alexander J P , Gayo Muhammad Natsir 
Published: April 2022

Zakat dalam agama Islam merupakan pembersih dari harta kekayaan. Selain membersihkan dari harta kekayaan, zakat juga meringankan beban mustahiq. Di Indonesia yang mayoritas pemeluk agama Islam, masalah zakat menjadi hal yang penting untuk dimaksimalkan pengelolaannya yang nantinya berguna untuk mengatasi masalah kemiskinan. Masjid Jami Nurul Hikmah merupakan lembaga keagamaan dan sosial yang berada di Kota Tangerang. Masalah yang sering dijumpai pada Masjid Jami Nurul Hikmah adalah cara dalam pemilihan mustahiq yang masih menggunakan cara manual sehingga sering menimbulkan masalah seperti lamanya proses pemilihan dan terjadinya salah hitung sehingga menimbulkan kurang akuratnya hasil seleksi mustahiq. Selain itu, tidak tersedianya akses informasi untu melihat mustahiq yang telah masuk kedalam daftar penerima zakat, mengakibatkan mustahiq yang sudah menerima zakat dapat menerima bantuan lebih dari satu kali dalam setahun. Kriteria penilaian dalam penentuan rekomendasi penerima zakat untuk mustahiq antara lain dengan melihat status tempat tinggal, penghasilan, status pekerjaan, jumlah tanggungan, dan kendaraan keluarga. Untuk mengatasi masalah tersebut, dibangun sebuah sistem pemberi rekomendasi yang dapat membantu pengelola zakat dalam penyaluran kepada penerima zakat. Metode Simple Additive Weighting (SAW) digunakan untuk menghitung nilai kriteria untuk menghasilkan rekomendasi penerima zakat. Dengan adanya sistem ini, pengelola zakat dapat member rekomendasi calon penerima zakat secara cepat dan akurat.
Kata kunci: Zakat, Rekomendasi , Sistem, Mustahiq
Peran penyuluh terhadap adopsi inovasi usaha ternak sapi potong di Kelurahan Karondoran Kecamatan Ranowulu Kota Bitung
Authors: Mokoagow A S , Lombogia S O. B , Lainawa J 
Published: April 2022

Penelitian ini dilaksanakan di Kecamatan Ranowulu, Kelurahan Karondoran, Kota Bitung pada bulan Februari 2020. Penelitian ini bertujuan untuk untuk mengetahui hubungan antara peran penyuluh dengan proses adopsi inovasi pengembangan usaha ternak sapi potong pada kelompok peternak ‘Cinta Damai” dan kelompok ‘Jempol’ di Kelurahan Karondoran. Penelitian ini berbentuk survey dengan menggunakan kuesioner. Penentuan sampel secara total sampling sebanyak 20 responden yang tergabung dalam kelompok ternak. Analisis data yang digunakan adalah analisis korelasi Rank Spearman (rs). Hasil penelitian menunjukkan terdapat hubungan antara peran penyuluh dengan persepsi peternak terhadap adopsi inovasi yang meliputi kesadaran, minat, menilai, mencoba dan tahap adopsi. Terdapat hubungan antara peran penyuluh dengan adopsi inovasi pengembangan produksi usaha peternakan sapi potong di kelompok peternak “Jempol” dan “Cinta Damai” di Kelurahan Karondoran, Kecamatan Ranowulu, kota Bitung.Kata kunci : Penyuluh, adopsi inovasi, sapi potong, kelompok peternak.
Penguatan Literasi Anak Di Desa Kuala Sempang Kabupaten Bintan
Authors: Cahya Anisa Nilam , Hartono Soni , Reni Reni , Hasanah Nur , Ajie Muhammad Fikri , Dian Muhammad , Rahman Fazlur , Wati Erna , Hidayat Arief , Hidayah Nur , Viana Okta , Liya Rosa , Rahmat Syahrul 
Published: April 2022

Penguatan literasi pada anak perlu ditanamkan sedini mungkin dan harus mendapatkan perhatian khusus dari semua pihak, lingkungan keluarga, sekolah, dan lingkungan masyarakat. Arus globalisasi yang melaju pesat memaksa negeri ini menerima suatu perubahan besar yang berpengaruh pada kehidupan masyarakat, dikarenakan adanya perkembangan teknologi, telekomunikasi, transportasi, ilmu pengetahuan dan aspek lainnya. Pengabdian ini dilakukan menggunakan pendekatan Asset Based Comunity Development (ABCD). Metode ABCD merupakan metode yang bertujuan untuk memanfaatkan kekuatan yang ada dalam masyarakat sebagai sarana pengembangan berkelanjutan yang memuat proses untuk melihat potensi apa saja yang dimiliki masyarakat. Tujuan dari pengabdian ini adalah menanamkan budaya literasi pada anak-anak di Desa Kuala Sempang Kabupaten Bintan, Kepulauan Riau. Penulis berupaya memberikan bantuan dengan optimalisasi perkembangan anak-anak, sehingga mengurangi hambatan dalam persoalan pembelajaran yang dianggap mereka sulit dipahami. Sejumlah program penguatan literasi yang dilakukan adalah optimalisasi pemanfaatan taman bacaan Al-Ilmi, penguatan literasi agama bagi pelajar TPQ, penguatan literasi budaya serta memberi bimbingan belajar bagi siswa sekolah dasar.
ANALISIS PENGARUH DISIPLIN, LINGKUNGAN KERJA TERHADAP KEPUASAN KERJA DAN KINERJA PEGAWAI PADA PENGADILAN AGAMA BANJARBARU
Authors: Fauzan Rahman  
Published: April 2022

ABSTRAK : Pegawai dalam melakukan pekerjaannya senantiasa dipengaruhi oleh beberapa faktor diantaranya disiplin, lingkungan dimana dia bekerja serta kepuasan yang dia dapatkan. Sehubungan dengan itu maka penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh: Analisis Pengaruh Disiplin, Lingkungan Kerja Terhadap Kepuasan Kerja dan Kinerja Pegawai pada Pengadila Agama Banjarbaru, dengan Kepuasan Kerja sebagai variabel intervening. Jenis Penelitian ini adalah penelitian Deskriptif Kuantitatif, dengan Populasi sebanyak 28 orang dan menggunakan sampel jenuh sebanyak 28 orang Pegawai pada Pengadilan Agama Banjarbaru. Data primer yang telah terkumpul di analisis dengan Analisis Regresi Linear Berganda dan Analisis Jalur Smart PLS. Hasil penelitian menunjukan bahwa: Disiplin kerja, Lingkungan Kerja berpengaruh positif dan signifikan terhadap kinerja pegawai pengadilan Agama Banjarbaru, dengan Kepuasan sebagai variabel intervening.

Kata Kunci: Disiplin Kerja, Lingkungan Kerja, Kepuasan Kerja, dan Kinerja Pegawai
MRM-Net: Towards Deep Multi-Resolution Mutual Learning for Progressive Image Inpainting
Authors: Zhang Huan , Zhang Zhao , Zhang Haijun , Yang Yi , Yan Shuicheng , Wang Meng 
Published: April 2022

<p>Deep image inpainting methods have improved the inpainting performance greatly due to the powerful representation ability of deep learning. However, current deep inpainting models still tend to produce unreasonable structures and blurry textures due to the ill-posed properties of the task, i.e., image inpainting is still a challenging topic. In this paper, we therefore propose a novel deep multi-resolution mutual learning (DMRML) strategy for progressive inpainting, which can fully explore the information from various resolutions. Specifically, we design a new image inpainting network, termed multi-resolution mutual network (MRM-Net), which takes the damaged images of various resolutions as input, then excavates and exploits the correlation among different resolutions to guide the image inpainting process. Technically, the setting of MRM-Net designs two new modules called multi-resolution information interaction (MRII) and adaptive content enhancement (ACE). MRII aims at discovering the correlation of multiple resolutions and exchanging information, and ACE focuses on enhancing the contents using the interacted features. We also present an memory preservation mechanism (MPM) to prevent from the information loss with the increasing layers. Extensive experiments on Paris Street View, Places2 and CelebA-HQ datasets demonstrate that our proposed MRM-Net can effectively recover the textures and structures, and performs favorably against other state-of-the-art methods. </p>