bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between dairy fat intake, milk-derived free fatty acids, and cardiometabolic risk in Dutch adults
Authors: Li Katherine J. , Brouwer-Brolsma Elske M. , Fleuti Charlotte , Badertscher René , Vergères Guy , Feskens Edith J. M. , Burton-Pimentel Kathryn J. 
Published: August 2022

AbstractPurposeMilk-derived free fatty acids (FFAs) may act as both biomarkers of intake and metabolic effect. In this study we explored associations between different types of dairy consumption, a selection of milk-derived free fatty acids, and cardiometabolic disease (CMD) risk factors.MethodsSixty-seven FFAs were quantified in the plasma of 131 free-living Dutch adults (median 60 years) using gas chromatography-flame ionization detector. Intakes of different dairy foods and groups were assessed using a food frequency questionnaire. Twelve different CMD risk factors were analyzed. Multiple linear regressions were used to evaluate the associations under study.ResultsBased on the fully adjusted models, 5 long-chain unsaturated FFAs (C18:1 t13 + c6 + c7 + u, C18:2 c9t11 + u, C20:1 c11, C20:3 c8c11c14, and C20:4 c5c8c11c14), 2 medium-chain saturated FFAs (C15, C15iso), and atransFFA (C16:1 t9) were positively associated with at least one variable of dairy intake, as well as plasma total and LDL cholesterol, blood pressure, and SCORE (p ≤ 0.05). A long-chain PUFA associated with high-fat fermented dairy intake (C18:2 t9t12), was negatively associated with serum triglyceride levels, and a long-chain saturated FFA associated with cheese intake (C18:1 u1) was negatively associated with plasma LDL cholesterol and serum triglyceride levels. No clear associations were observed between dairy intake and CMD risk factors.ConclusionMilk-derived FFAs could act as sensitive biomarkers for dairy intake and metabolism, allowing the association between dairy and CMD risk to be more precisely evaluated.
Studying coalescence at different lengthscales: from films to droplets
Authors: Chatzigiannakis Emmanouil , Chen Yun , Bachnak Rana , Dutcher Cari S. , Vermant Jan 
Published: August 2022

AbstractThe hydrodynamics of thin films is an important factor when it comes to the stability and rheology of multiphasic materials, such as foams, emulsions, and polymer blends. However, there have so far been only limited experimental studies addressing the dynamics of individual free-standing thin films at conditions similar to those encountered on macroscopic scales. In this article, we study a well-characterized system of a water-in-oil emulsion stabilized by a non-ionic surfactant (SPAN80) close to its CMC. We employ a dynamic thin film balance, to study the dynamics of freestanding films under both constant and time-varied pressure drops. We compare with the recently published results of Narayan et al. (2020) on colliding droplets of the same system with a hydrodynamic microfluidic trap, and show for the first time that agreement between the two lengthscales is possible, which indicates that the coalescence is indeed dominated by the dynamics in the film. We then address the scatter in the coalescence times and show that it can be affected by extrinsic factors, as well as by variations in the collision angle. Finally, we discuss the difficulties of extracting insight on the coalescence mechanism from coalescence time distributions when different effects such as impurities, small pressure variations, collision angle variations, and possible Marangoni-related instabilities are at play.
Optical coherence tomography reveals retinal thinning in schizophrenia spectrum disorders
Authors: Boudriot Emanuel , Schworm Benedikt , Slapakova Lenka , Hanken Katharina , Jäger Iris , Stephan Marius , Gabriel Vanessa , Ioannou Georgios , Melcher Julian , Hasanaj Genc , Campana Mattia , Moussiopoulou Joanna , Löhrs Lisa , Hasan Alkomiet , Falkai Peter , Pogarell Oliver , Priglinger Siegfried , Keeser Daniel , Kern Christoph , Wagner Elias , Raabe Florian J. 
Published: August 2022

AbstractBackgroundSchizophrenia spectrum disorders (SSDs) are presumed to be associated with retinal thinning. However, evidence is lacking as to whether these retinal alterations reflect a disease-specific process or are rather a consequence of comorbid diseases or concomitant microvascular impairment.MethodsThe study included 126 eyes of 65 patients with SSDs and 143 eyes of 72 healthy controls. We examined macula and optic disc measures by optical coherence tomography (OCT) and OCT angiography (OCT-A). Additive mixed models were used to assess the impact of SSDs on retinal thickness and perfusion and to explore the association of retinal and clinical disease-related parameters by controlling for several ocular and systemic covariates (age, sex, spherical equivalent, intraocular pressure, body mass index, diabetes, hypertension, smoking status, and OCT signal strength).ResultsOCT revealed significantly lower parafoveal macular, macular ganglion cell–inner plexiform layer (GCIPL), and macular retinal nerve fiber layer (RNFL) thickness and thinner mean and superior peripapillary RNFL in SSDs. In contrast, the applied OCT-A investigations, which included macular and peripapillary perfusion density, macular vessel density, and size of the foveal avascular zone, did not reveal any significant between-group differences. Finally, a longer duration of illness and higher chlorpromazine equivalent doses were associated with lower parafoveal macular and macular RNFL thickness.ConclusionsThis study strengthens the evidence for disease-related retinal thinning in SSDs.
Claudin-18 expression in small bowel adenocarcinoma: a clinico-pathologic study
Authors: Arpa Giovanni , Fassan Matteo , Guerini Camilla , Quaquarini Erica , Grillo Federica , Angerilli Valentina , Guzzardo Vincenza , Lonardi Sara , Bergamo Francesca , Lenti Marco Vincenzo , Pedrazzoli Paolo , Paulli Marco , Di Sabatino Antonio , Vanoli Alessandro 
Published: August 2022

AbstractNon-ampullary small bowel adenocarcinoma is a rare neoplasm with an ominous prognosis, whose incidence is higher in some chronic immuno-inflammatory conditions, such as coeliac and Crohn’s disease. Recently, claudin 18.2, a transmembrane protein normally expressed in gastric mucosa, has been recognized as a novel pan-cancer therapeutic target, and several clinical trials with claudin-18-directed drugs have shown promising results on various gastrointestinal malignancies. This is the first study focusing on claudin-18 expression in small bowel adenocarcinomas. The immunohistochemical expression of claudin-18 (clone 43-14A) was assessed in 81 small bowel adenocarcinomas of diverse aetiologies and correlated with several clinico-pathologic features and patient survival. We found that 28% of adenocarcinomas were immunoreactive for claudin-18, with cutoff values of ≥1% at any intensity, while 6% of cancers showed immunoexpression of ≥75% with 2+/3+ score. Moreover, claudin-18 (≥1%) was positively associated with cytokeratin 7 (CK7) and MUC5AC expression, showing CK7+/MUC5AC+ carcinomas the highest rate of positive cases, whereas a negative correlation was found between claudin-18 and CDX2 expression. In addition, some cancer-adjacent dysplastic growths and foci of gastric-type metaplasia in Crohn’s disease-associated cases showed claudin-18 immunoreactivity. Survival analysis showed a non-significant trend towards a worse cancer-specific survival for claudin-18-positive cases. A fraction of small bowel adenocarcinomas, mainly sporadic or Crohn’s disease-associated, and often exhibiting a non-intestinal immunoprofile, expressed claudin-18, suggesting that claudin-18-directed targeted therapy is worth investigating in such cancers.
Low-volume magmatism linked to flank deformation on Isla Santa Cruz, Galápagos Archipelago, using cosmogenic 3He exposure and 40Ar/39Ar dating of fault scarps and lavas
Authors: Schwartz D. M. , Harpp K. , Kurz M. D. , Wilson E. , Van Kirk R. 
Published: August 2022

Abstract
Isla Santa Cruz is a volcanic island located in the central Galápagos Archipelago. The island’s northern and southern flanks are deformed by E–W-trending normal faults not observed on the younger Galápagos shields, and Santa Cruz lacks the large summit calderas that characterize those structures. To construct a chronology of volcanism and deformation on Santa Cruz, we employ 40Ar/39Ar geochronology of lavas and 3He exposure dating of fault scarps from across the island. The combination of Ar–Ar dating with in situ-produced cosmogenic exposure age data provides a powerful tool to evaluate fault chronologies. The 40Ar/39Ar ages indicate that the island has been volcanically active since at least 1.62 ± 0.030 Ma (2SD). Volcanism deposited lavas over the entire island until ~ 200 ka, when it became focused along an E–W-trending summit vent system; all dated lavas < 200 ka were emplaced on the southern flank. Structural observations suggest that the island has experienced two major faulting episodes. Crosscutting relationships of lavas indicate that north flank faults formed after 1.16 ± 0.070 Ma, but likely before 416 ± 36 ka, whereas the faults on the southern flank of the island initiated between 201 ± 37 and 32.6 ± 4.6 ka, based on 3He exposure dating of fault surfaces. The data are consistent with a model wherein the northeastern faults are associated with regional extension owing to the young volcano’s location closer to the Galápagos Spreading Center at the time. The second phase of volcanism is contemporaneous with the formation of the southern faults. The expression of this younger, low-volume volcanic phase was likely related to the elongate island morphology established during earlier deformation. The complex feedback between tectonic and volcanic processes responsible for southward spreading along the southern flank likely generated persistent E-W-oriented magmatic intrusions. The formation of the Galápagos Transform Fault and sea-level fluctuations may be the primary causes of eruptive and deformational episodes on Santa Cruz.
The association between early childhood onset epilepsy and attention-deficit hyperactivity disorder (ADHD) in 3237 children and adolescents with Autism Spectrum Disorder (ASD): a historical longitudinal cohort data linkage study
Authors: Carson Lauren , Parlatini Valeria , Safa Tara , Baig Benjamin , Shetty Hitesh , Phillips-Owen Jacqueline , Prasad Vibhore , Downs Johnny 
Published: August 2022

AbstractChildren and young people with Autism Spectrum Disorder (ASD) have an increased risk of comorbidities, such as epilepsy and Attention-Deficit/Hyperactivity Disorder (ADHD). However, little is known about the relationship between early childhood epilepsy (below age 7) and later ADHD diagnosis (at age 7 or above) in ASD. In this historical cohort study, we examined this relationship using an innovative data source, which included linked data from routinely collected acute hospital paediatric records and childhood community and inpatient psychiatric records. In a large sample of children and young people with ASD (N = 3237), we conducted a longitudinal analysis to examine early childhood epilepsy as a risk factor for ADHD diagnosis while adjusting for potential confounders, including socio-demographic characteristics, intellectual disability, family history of epilepsy and associated physical conditions. We found that ASD children and young people diagnosed with early childhood epilepsy had nearly a twofold increase in risk of developing ADHD later in life, an association which persisted after adjusting for potential confounders (adjusted OR = 1.72, CI95% = 1.13–2.62). This study suggests that sensitive monitoring of ADHD symptoms in children with ASD who have a history of childhood epilepsy may be important to promote early detection and treatment. It also highlights how linked electronic health records can be used to examine potential risk factors over time for multimorbidity in neurodevelopmental conditions.
Body computed tomography in sepsis: predictors of CT findings and patient outcomes in a retrospective medical ICU cohort study
Authors: Pohlan Julian , Witham Denis , Farkic Lara , Anhamm Melina , Schnorr Alexandra , Muench Gloria , Breiling Karim , Ahlborn Robert , Herz Enrico , Rubarth Kerstin , Praeger Damaris , Dewey Marc 
Published: August 2022

Abstract

Background
Sepsis is a life-threatening condition that requires immediate focus identification and control. However, international sepsis guidelines do not provide information on imaging choice.

Purpose
To identify predictors of CT findings and patient outcomes in a population of septic patients from a medical ICU.

Material and methods
A full-text search in the radiological information system (RIS) retrieved 227 body CT examinations conducted to identify infectious sources in 2018. CT reports were categorized according to identified foci and their diagnostic certainty. Diagnostic accuracy of CT was compared to microbiological results. Clinical and laboratory information was gathered. Statistical analysis was performed using nonparametric tests and logistic regression analysis.

Results
CT revealed more positive infectious foci 52.4% (n = 191/227) than microbiological tests 39.3% (n = 79/201). There were no significant differences between focus-positive CT scans with regard to positive microbiological testing (p = 0.32). Sequential organ failure assessment (SOFA) scores were slightly but nonsignificantly higher in patients with a focus-positive CT, odds ratio (OR) = 0.999 (95% CI 0.997–1.001) with p = 0.52. Among C-reactive protein (CRP), procalcitonin (PCT), and leukocytes, in focus-positive versus focus-negative CT scans, CRP showed a minor but statistically significant elevation in the group with focus-positive CT scans (OR = 1.004, 95% CI = 1.000–1.007, p = 0.04). No significant association was found for PCT (OR = 1.007, 95% CI = 0.991–1.023; p = 0.40) or leukocytes (OR = 1.003, 95% CI = 0.970–1.038; p = 0.85). In 33.5% (n = 76/227) of cases, the CT findings had at least one therapeutic consequence. In 81.6% (n = 62/76), the CT findings resulted in one consequence, in 14.5% (n = 11/76) in two consequences, and in 3.9% (n = 3/76) in three consequences. There was no significant association between focus-positive CT scans and mortality (p = 0.81).

Conclusion
In this population of septic patients in medical intensive care, microbiological analysis complemented CT findings. Both clinical and laboratory parameters were not predictive of CT findings. While therapeutic consequences of CT findings in this study population underline the role of CT for decision making in septic patients, CT findings do not predict patient outcomes in this retrospective analysis.
Environmental adjustment of the EU27 GDP: an econometric quantitative model
Authors: Galiano Bastarrica Luis Antonio , Buitrago Esquinas Eva M. , Caraballo Pou María Ángeles , Yñiguez Ovando Rocío 
Published: August 2022

AbstractThe use of natural resources as an input to economic growth and the interactions between economic and ecological systems have resulted in an accumulation of environmental externalities. This accumulation can negatively affect future levels of welfare and economic growth. In this paper, such dynamics are assessed and quantified by introducing explicit environmental externality variables in a production function. This is performed in an endogenous growth model where cumulative environmental externalities interact with economic growth. Using efficiency analysis, a dynamic econometric model is estimated showing the significance of a negative influence of past levels of use of natural resources on GDP over a broad range of stochastic frontier analysis estimations. The results are applied to propose an alternative specification to the production function of a modelling tool used by the European Commission for the assessment of climate policies in the European Union. The findings show that observed GDP is overestimated when environmental externalities are not considered.
Complementarity of two approaches based on the use of high-resolution mass spectrometry for the determination of multi-class antibiotics in water. Photodegradation studies and non-target screenings
Authors: Vazquez Lua , Llompart Maria , Dagnac Thierry 
Published: August 2022

Abstract
The development of analytical methodologies to monitor different antibiotic families in water and the implementation of alternatives for their efficient elimination are a great challenge. The aim of this research was to develop a method based on solid-phase extraction followed by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry to analyse multi-class antibiotics, including macrolides, cephalosporins, fluoroquinolones, sulfonamides and diaminopyrimidines, in waters. Several parameters affecting the extraction such as the sample pH, type of sorbent and cartridge, elution volume and breakthrough volume were optimized. The method was validated in real samples, and matrix effect was assessed, demonstrating that the use of isotopically labelled surrogate compounds was mandatory to avoid standard addition calibration for each individual samples. Urban and hospital wastewater samples, as well as natural waters, were analysed, confirming the presence of 12 of the 14 target compounds at concentrations up to 3.5 µg L−1. Non-target analysis based on data-independent workflow was also performed, enabling the identification of 94 pollutants. Preliminary photodegradation experiments were also assessed, revealing the total removal of many target compounds after the first 5–10 min of UVC irradiation. In addition, 20 by-products formed after photolysis could be identified using a non-target approach.
Pompe Disease: a Clinical, Diagnostic, and Therapeutic Overview
Authors: Stevens David , Milani-Nejad Shadi , Mozaffar Tahseen 
Published: August 2022

AbstractPurpose of ReviewThis review summarizes the clinical presentation and provides an update on the current strategies for diagnosis of Pompe disease. We will review the available treatment options. We examine newly approved treatments as well as upcoming therapies in this condition. We also provide commentary on the unmet needs in clinical management and research for this disease.Recent FindingsIn March 2015, Pompe disease was added to the Recommended Uniform Screening Panel (RUSP) and since then a number of states have added Pompe disease to their slate of diseases for their Newborn Screening (NBS) program. Data emerging from these programs is revising our knowledge of incidence of Pompe disease. In 2021, two randomized controlled trials involving new forms of enzyme replacement therapy (ERT) were completed and one new product is already FDA-approved and on the market, whereas the other product will come up for FDA review in the fall. Neither of the new ERT were shown to be superior to the standard of care product,alglucosidase. The long-term effectiveness of these newer forms of ERT is unclear. Newer versions of the ERT are in development in addition to multiple different strategies of gene therapy to deliver GAA, the gene responsible for producing acid alpha-glucosidase, the defective protein in Pompe Disease. Glycogen substrate reduction is also in development in Pompe disease and other glycogen storage disorders.SummaryThere are significant unmet needs as it relates to clinical care and therapeutics in Pompe disease as well as in research. The currently available treatments lose effectiveness over the long run and do not have penetration into neuronal tissues and inconsistent penetration in certain muscles. More definitive gene therapy and enzyme replacement strategies are currently in development and testing.
METTL13 facilitates cell growth and metastasis in gastric cancer via an eEF1A/HN1L positive feedback circuit
Authors: Wu Qiong , Hu Qingqing , Hai Yanan , Li Yandong , Gao Yong 
Published: August 2022

AbstractAlthough improved treatment could inhibit progression of gastric cancer (GC), the recurrence and metastasis remain challenging issues. Methyltransferase like 13 (METTL13) has been implicated in most human cancers, but its function and mechanism in GC remain elusive. In the present study, we evaluated its expression in GC samples and found it was aberrantly overexpressed in cancer tissues than that in normal stomach tissues. High expression of METTL13 was closely associated with age, tumor size and T classification. Biological experiments showed that silencing METTL13 suppressed gastric cancer cell proliferation and metastasis in vivo and vitro, whereas opposite effects were observed upon METTL13 overexpression. Further mechanistic explorations revealed that METTL13 regulated the expression of HN1L (Hematological and neurological expressed 1-like), which is reported to be an oncogene in various cancers. Knockdown of HN1L dampened gastric cancer cell growth induced by METTL13. Eukaryotic translation elongation factor-1A (eEF1A), the present sole methylation substrate of METTL13, was involved in the regulation of HN1L by METTL13 in a K55 methylation independent manner. In addition, we also found HN1L could facilitate METTL13 expression in GC cells consistent with a previous report in hepatocellular carcinoma. Thus, these findings demonstrate a METTL13/eEF1A/HN1L positive feedback circuit promoting gastric cancer development and metastasis. It will help develop promising diagnostic and therapeutic targets for this disease.
Broadband light management in hydrogel glass for energy efficient windows
Authors: Fu Jia , Feng Chunzao , Liao Yutian , Mao Mingran , Liu Huidong , Liu Kang 
Published: August 2022

AbstractWindows are critically important components in building envelopes that have a significant effect on the integral energy budget. For energy saving, here we propose a novel design of hydrogel-glass which consists of a layer of hydrogel and a layer of normal glass. Compared with traditional glass, the hydrogel-glass possesses a higher level of visible light transmission, stronger near-infrared light blocking, and higher mid-infrared thermal emittance. With these properties, hydrogel-glass based windows can enhance indoor illumination and reduce the temperature, reducing energy use for both lighting and cooling. Energy savings ranging from 2.37 to 10.45 MJ/m2 per year can be achieved for typical school buildings located in different cities around the world according to our simulations. With broadband light management covering the visible and thermal infrared regions of the spectrum, hydrogel-glass shows great potential for application in energy-saving windows.
Graphical Abstract
Quantum computing
Authors: Rietsche Roman , Dremel Christian , Bosch Samuel , Steinacker Léa , Meckel Miriam , Leimeister Jan-Marco 
Published: August 2022

AbstractQuantum computing promises to be the next disruptive technology, with numerous possible applications and implications for organizations and markets. Quantum computers exploit principles of quantum mechanics, such as superposition and entanglement, to represent data and perform operations on them. Both of these principles enable quantum computers to solve very specific, complex problems significantly faster than standard computers. Against this backdrop, this fundamental gives a brief overview of the three layers of a quantum computer: hardware, system software, and application layer. Furthermore, we introduce potential application areas of quantum computing and possible research directions for the field of information systems.