bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-invasive acupoint stimulation as a complementary therapy for fatigue in hemodialysis patients: A systematic review
Authors: Susanto Gunawan , Upoyo Arif Setyo 
Published: January 2025

Background: Patients with chronic kidney disease (CKD) undergoing hemodialysis often experience complex and variable fatigue, which significantly impacts their quality of life. Several factors can cause this fatigue, including the dialysis procedure itself and conditions such as depression, anemia, sleep disorders, and restless leg syndrome. Non-pharmacological methods, such as non-invasive acupoint stimulation, have been used to manage fatigue. However, a systematic review of the literature is needed to determine the effectiveness of this approach.
Purpose: To evaluate the effectiveness of non-invasive acupoint stimulation as a complementary therapy in reducing fatigue levels in patients undergoing hemodialysis.
Method: The databases Google Scholar, ResearchGate, and ProQuest were used to identify English-language research publications from 2013 to 2024. These publications included two from Iran, one from Turkey, one from India, one from Korea, and two from Taiwan. The selection of publications followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Quality evaluation was conducted using the Joanna Briggs Institute (JBI) Critical Appraisal Skills Program.
Results: Findings indicate that all evaluated non-invasive acupoint stimulation methods significantly reduced fatigue. Electrical stimulation techniques, including electro-stimulation and Transcutaneous Electrical Acupoint Stimulation (TEAS), demonstrated consistent effectiveness. Manual acupressure and auricular acupressure also showed significant improvements in fatigue levels. Additionally, radiation stimulation using far-infrared light yielded promising results. Variations in the number of stimulation points, session duration, and total intervention length still produced significant reductions in fatigue, suggesting that non-invasive acupoint stimulation methods can be effective despite methodological differences.
Conclusion: Non-invasive acupoint stimulation methods show great potential in managing fatigue in hemodialysis patients. Despite methodological variations, all studies reported significant fatigue reductions, supporting the integration of non-invasive acupoint stimulation methods into clinical practice to improve patients' quality of life. Further research is needed to develop intervention protocols and confirm these findings.
Evaluation of the Antimicrobial Potential of <i>Pleurotus ostreatus</i> Extracts
Authors: Neha Y. D. , Girish K. 
Published: January 2025

Antimicrobial activity of Pleurotus ostreatus was studied in vitro using its aqueous and methanolic extracts, against nine human pathogenic bacteria (MTCC cultures) such as Bacillus subtilis, Listeria monocytogenes, Staphylococcus aureus, Streptococcus pneumoniae - Gram positive bacteria; Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Proteus vulgaris, Salmonella enterica ser. typhi and Shigella flexneri - Gram negative bacteria. Antifungal potential was screened against phytopathogenic fungi like Alternaria sp., Aspergillus sp., Fusarium sp. and Helminthosporium sp. The P. ostreatus aqueous extract failed to show growth inhibitory effect against any of the human pathogenic bacteria or phytopathogenic fungi studied. The P. ostreatus methanolic extract exhibited significant inhibition of all the bacteria tested at higher concentrations of 2000, 3000, 4000 and 5000 ppm. But, even P. ostreatus methanolic extract could not inhibit the growth of phytopathogenic fungi studied, at any of the concentrations screened. P. ostreatus methanolic extract was found to have phytochemicals such as alkaloids, flavonoids, phenols, saponins, steroids, tannins, and terpenoids. The results of present studies reveal the antibacterial potential of Pleurotus ostreatus, which could be further evaluated to obtain potent antibacterial bioactive principles for new drug development.
Comparative study regarding the stability of a proximal ulnar stump with or without distal oblique bundle reconstruction during the Sauvé‒Kapandji procedure: a finite-element analysis
Authors: Yin Shanqing , Zhang Chenxi , Huang Yaopeng , Pan Jiadong , Wang Xin , Liu Xiaodong 
Published: January 2025

BackgroundThe most common postoperative complication of the Sauvé‒Kapandji (S-K) procedure is proximal ulnar stump instability. The distal oblique bundle (DOB) is a stable tissue used to stabilize the distal radioulnar joint. This study created finite-element models of the distal oblique bundle (DOB) to determine its effect on the proximal ulnar stump instability encountered during the Sauvé‒Kapandji procedure.PurposeWe hypothesized that a proximal ulnar stump with distal oblique bundle reconstruction would provide greater stability than a proximal ulnar stump without distal oblique bundle reconstruction.MethodsDetailed CT imaging data acquired from a pathological specimen of the wrist joint were imported into a finite-element analysis software package, and the regions of interest, including bone, cartilage, ligaments and tendons, were extracted to create a 3-dimensional model. The volar/dorsal and medial/lateral displacements of the proximal ulnar stump and the stress changes exhibited by the bone and distal oblique bundle tendon were measured with and without DOB reconstruction under 60° pronation, neutrality, and 60° supination.ResultsWhen utilizing DOB reconstruction, the displacement of the radius relative to the proximal ulna stump was approximately 17.89 mm in the neutral position. The bone stress values corresponding to the neutral position, 60° pronation and 60° pronation were 1.01, 18.32 and 14.69 MPa, respectively. The stress peaks of the DOB tendon structure corresponding to the neutral position, 60° pronation and 60° pronation were 0.07 MPa, 2.21 and 1.55 MPa, respectively. Without DOB reconstruction, the displacement of the radius relative to the proximal ulna stump was approximately 18.05 mm in the neutral position. Under 60° pronation and 60° supination, the displacement values were approximately 14.62 mm and 16.89 mm, respectively. The peak bone stress values corresponding to the neutral position, 60° pronation and 60° supination were 1.02, 18.29 MPa and 14.41 MPa, respectively. The stress peaks of the tendon structure corresponding to the neutral position, 60° pronation and 60° pronation were 0.03, 0.87 and 0.85 MPa, respectively.ConclusionDOB reconstruction is capable of improving the stability of the proximal ulnar stump during the Sauvé–Kapandji procedure.
Navigating the wild west: a review of guidance on clinical communications using personal BYOD, IM and third-party apps in the UK and Ireland
Authors: John Bernadette , Heavin Ciara , Roberts Anthony 
Published: January 2025

IntroductionThe ubiquity of Bring Your Own Device (BYOD) personal smartphones, Instant Messaging (IM), and third-party apps, has made these technologies compelling for efficient communications between clinicians regarding patient care. However, the sensitivity of patient-related information necessitates secure, GDPR compliant modalities that prevent unauthorised access and ensure confidentiality. This scoping review explores existing guidelines, policies, and regulations that advise clinicians in the UK and Ireland on the secure use of these digital communication tools.MethodsFollowing the Joanna Briggs Institute (JBI) updated Framework for Scoping Reviews and the PRISMA ScR guidelines, this review examines the literature to identify relevant guidelines, policies, and regulations informing current clinical practice on the use of this technology. Academic databases including OneSearch, Embase, EBSCO, PubMed, Medline, and CINAHL were searched, in addition to hand searches of professional entities' websites, including trade unions, regulators, two national health systems, and several employers. Direct inquiries were made to 69 professional entities via telephone, email, websites, and X (formerly known as Twitter).ResultsThe review identified 18 papers that broadly recognise the importance of secure communication however, a lack of information on the appropriate selection or configuration of these popular technologies was evident. Most guidelines emphasise general security and data protection standards rather than providing clear actionable recommendations for technology use, thereby leaving a significant gap in technical guidance for clinicians.DiscussionThere is a distinct lack of detailed, specific, consistent technical guidance available to clinicians. This review evidences an urgent requirement for enhanced guidelines that specify the most secure platforms, appropriate features, and configuration to maximise the security and confidentiality of clinical communications. Further research is recommended to develop comprehensive, actionable advice for clinicians.
An investigation of a hemophilia A female with heterozygous intron 22 inversion and skewed X chromosome inactivation
Authors: Tan Xiaoyan , Yang Yi , Wu Xia , Zhu Jing , Wang Teng , Jiang Huihui , Chen Shu , Lou Shifeng 
Published: January 2025

ObjectivesHemophilia A (HA) is an X-linked recessive inherited bleeding disorder that typically affects men. Women are usually asymptomatic carriers, and rarely presenting with severe or moderately severe phenotype. This study aims to describe a case of a 17-year-old girl with moderate HA, investigating the mechanisms of her condition and the genetic basis within her family.MethodsWe conducted coagulation tests and bleeding assessments to evaluate her bleeding phenotype. Molecular genetic examinations, karyotype analysis, X-chromosome inactivation testing, and targeted bioinformatic analysis were used to identify potential genetic etiologies.ResultsThe proband exhibited a severe bleeding phenotype and was found to be a heterozygous carrier of an intron 22 inversion (Inv22) with a normal chromosomal karyotype. No other hemostatic defects were identified through whole exome sequencing. The proband’s mother and monozygotic twin sister are also Inv22 carriers, yet remain asymptomatic with normal FVIII activity. X-chromosome inactivation experiments revealed unbalanced inactivation in the proband, leading to the silencing of the healthy X copy. Notably, several novel X-linked gene mutations (SHROOM2, RPGR, VCX3B, GAGE, GCNA, ZNF280C, CT45A, and XK) were identified in the proband compared to her monozygotic twin sister, though their impact on X-chromosome inactivation remains unclear.ConclusionOur findings suggest that the proband’s bleeding phenotype results from unbalanced X-chromosome inactivation. This research marks the first analysis of X chromosome-related gene mutations among monozygotic twins who are carriers of hemophilia A, laying the groundwork for further investigations into the disorder’s pathogenesis in women and highlighting the complexities in genetic counseling.
Efficacy and safety of acupuncture for postoperative gastroparesis syndrome: a systematic review and meta-analysis
Authors: Xv Yichuan , Feng Yiyi , Lin Jiang 
Published: January 2025

BackgroundPostoperative gastroparesis syndrome (PGS) is a common postoperative complication characterized by epigastralgia, nausea, and vomiting. Acupuncture is widely used to aid recovery, but its efficacy and safety have not been systematically evaluated.MethodWe retrieved randomized controlled trials (RCTs) using acupuncture as the primary intervention from six databases. After study selection and data extraction, a meta-analysis was performed using Review Manager 5.4.1. Study quality was assessed with the Cochrane risk of bias tool, and publication bias was quantitatively evaluated using Egger’s test and was corrected using the trimming and filling method.ResultsA total of 12 RCTs involving 709 participants (363 in the acupuncture group and 346 in the control group) were included. The meta-analysis showed a significantly higher overall response rate in the acupuncture group than the control group [RD = 0.16, 95% CI (0.11, 0.21), p &lt; 0.001]. Acupuncture also reduced gastric tube indwelling time [MD = −2.36, 95% CI (−3.14, −1.59), p &lt; 0.001], decreased gastric juice drainage [MD = −166.88, 95% CI (−176.57, −156.18), p &lt; 0.001], and improved serum motilin levels [MD = 41.65, 95% CI (30.14, 53.15), p &lt; 0.001]. Four studies reported no adverse events in either group, but the majority of studies did not provide safety data.ConclusionAcupuncture may alleviate clinical symptoms and shorten hospitalization, potentially by enhancing gastrointestinal motility. However, the lack of safety data in the majority of studies raises concerns about the reliability of these findings and the transferability of the results. Future trials should focus on rigorous randomization, blinding, and comprehensive safety reporting to improve the quality of evidence in this field.Systematic review registrationID: INPLASY202320035 URL: https://inplasy.com/inplasy-2023-2-0035/
Efficacy of onabotulinumtoxinA treatment in episodic migraine
Authors: Al-Hashel Jasem , Alroughani Raed , Almojel Malak , Ahmed Samar Farouk 
Published: January 2025

BackgroundOnabotulinumtoxinA (BoNT-A) is approved as a prophylactic treatment of chronic migraine (CM) only. We aimed to assess the efficacy and safety of BoNT-A in the treatment of episodic migraine (EM).MethodsThis is a prospective study included migraine patients, aged 18–65 years, and completed 1 year treatment with BoNT-A. Patients received 4 courses of BoNT-A treatment. Patient’s headache was assessed by headache diary at baseline, and before every injection. Migraine Specific Quality of Life Questionnaire (MSQ) and work productivity were collected at baseline and in their last visit. Adverse events (AEs) were reported.ResultsThe study recruited 210 patients. Between baseline and the final visit, there were a significant reduction in migraine days, analgesic consumption days, and headache severity (9.54 ± 1.70 versus 4.58 ± 2.77, p &lt; 0.001), (8.47 ± 1.49 versus 2.98 ± 0.21, p &lt; 0.001), (8.37 ± 0.72 versus 2.54 ± 0.18, p &lt; 0.001), respectively. BoNT-A treatment reduced the mean number of missed hours from work and daily activities over a 7-day period (4.63 ± 2.39 versus 6.26 ± 2.04, p &lt; 0.001); (2.24 ± 3.30 versus 3.94 ± 3. 45; p &lt; 0.001). Treatment with BoNT-A significantly improved the MSQ scores at last visit versus baseline visit, MSQ Role Function-Restrictive (51.55 ± 29.12 vs. 26.89 ± 17.42; p &lt; 0.001), MSQ Role Function-Preventive (56.07 ± 24.73 vs. 30.64 ± 15.25; p &lt; 0.001), and for MSQ Emotional Function (76.47 ± 115.29 vs. 35.12 ± 20.83; p &lt; 0.001). Fifty-four patients (14.4%) experienced mild and short-lasting AEs.ConclusionBoNT-A is an effective and well tolerated therapy in the prophylaxis of EM. It improved MSQ and WPAI.
Efficacy and safety of interferon-alpha 1b injection into the intervertebral foramen with ultrasonic guidance in patients with postherpetic neuralgia: study protocol for a randomized, double-blind, placebo-controlled, multicenter clinical trial
Authors: Hu Hui-Min , Liu Wen-Hui , Li Chen , Shi Qing , Liu Chun-Hua , Liu An-Xiang , Li Yi-Fan , Zhang Yi , Mao Peng , Fan Bi-Fa 
Published: January 2025

PurposePostherpetic neuralgia (PHN) is a type of refractory neuropathic pain that causes significant suffering, disability, economic loss, and medical burden. In this study, we aim to evaluate the efficacy and safety of interferon (IFN)-α1b injection into the intervertebral foramen of patients with PHN.Patients and methodsThis is a study protocol for a randomized, double-blind placebo-controlled multicenter clinical trial. A total of 200 participants with PHN from 11 hospitals will be recruited and randomly assigned to the treatment group administered with IFN-α1b and control group treated with placebo in a 1:1 ratio. Both groups will also receive oral pregabalin 150 mg twice daily and lidocaine injection into the intervertebral foramen as conventional therapy. This trial will involve a screening period, a 2-week intervention, and a 3-month follow-up. The primary outcomes will include the visual analog scale score and duration of pain relief. The secondary outcomes will include the 36-item short-form, dosage and duration of painkillers taken, viral load of varicella-zoster virus DNA, humoral cytokine level, and dosage and frequency of rescue medication. All adverse events and severe adverse events will be assessed during the study.ConclusionThis study is expected to provide evidence for the efficacy and safety of IFN-α1b injection into the intervertebral foramen in patients with PHN.Clinical trial registrationhttps://www.chictr.org.cn/indexEN.html, identifier ChiCTR240008996.
Exploring lifestyle and dietary pattern shifts among Saudi adults during COVID-19 pandemic: insights from a cross-sectional examination
Authors: Al-Mana Najlaa M. , Zareef Tahani A. , Albathi Fatmah A. , Awney Hala A. , Baeshen Farah , Abdullah Renad 
Published: January 2025

BackgroundSince the emergence of COVID-19 and the subsequent imposition of lockdown and movement restrictions, the world has witnessed fundamental lifestyle changes including alterations in dietary patterns and food consumption habits. Here, we investigated how the COVID-19 lockdown impacted dietary patterns and eating behaviors in the Saudi population.MethodologyThis cross-sectional study enrolled 427 participants aged 18 years or more, with 258 of them completing the survey. The survey included questions about demographic and dietary patterns during the COVID-19 lockdown. Data were collected and dietary behaviors before and during the lockdown in Jeddah, Saudi Arabia, were analyzed.ResultsThe number of participants who considered lunch as their primary meal significantly decreased (p &lt; 0.001) during the COVID-19 lockdown (74%), compared to before it (86%). By contrast, the number of participants who considered dinner as their primary meal remained almost unchanged (p = 0.079) during (79.1%) and before (84.1%) the lockdown. However, snack consumption significantly increased (p &lt; 0.001) while fast-food consumption significantly decreased (p &lt; 0.01) during the lockdown period. Our results also revealed a significant increase (p &lt; 0.01) in water and coffee intake during the lockdown, with a significant rise in dessert consumption (p &lt; 0.01).ConclusionOur results demonstrate that the COVID-19 lockdown caused a marked shift in dietary patterns and eating behaviors among the Saudi population. Notable changes were observed in overall food preferences after the lockdowns were imposed, with reduced consumption of fast foods and increased fluid intake.
Liquid chromatography-tandem mass spectrometry for the quantification of ripretinib and its metabolites DP-5439 in human plasma
Authors: Lin Jiahui , Jiang Aiting , Zheng Juntao , Wu Jingjing , Li Hao , Cai Shirong , He Yulong , Chen Xiao , Zhong Guoping , Tang Ke-Jing , Zhang Xinhua , Xia Yanzhe 
Published: January 2025

BackgroundRipretinib, a broad-spectrum tyrosine kinase inhibitor, has been approved for the treatment of advanced gastrointestinal stromal tumors in adult patients. Clinical studies have shown that higher in vivo exposure of ripretinib correlates with improved efficacy, highlighting the potential clinical significance of therapeutic drug monitoring. In this study, a simple and stable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was attempted to be established and validated for pharmacokinetic studies of ripretinib and its metabolite DP-5439 and therapeutic drug monitoring in human plasma.MethodRipretinib and DP-5439 were separated by chromatography using a Thermofisher Hypersil GOLDTM C18 HPLC column. The mobile phase for gradient elution is composed of 0.1% formic acid in water and acetonitrile. Multiple reaction monitoring was implemented along with electrospray ionization positive mode for detection. The ion pairs of ripretinib, DP-5439 and internal standard D8-ripretinib were m/z 510.1→m/z 417, m/z 496.11→m/z 402.9 and m/z 518.15→m/z 420, respectively. Plasma samples from ripretinib-treated patients of our hospital were collected for pharmacokinetic analysis.ResultsRipretinib and DP-5439 demonstrated a strong linear relationship over 10–5,000 μg/L (R2 &gt; 0.99). Accuracy, precision, specificity, recoveries, matrix effect, stability, and dilution effect were all validated and found to meet the required criteria. Following validation, the method was utilized to determine plasma samples from patients treated with ripretinib. The median steady-state trough concentrations (Cmin, range) were 398.50 (66.98 ∼ 1,458.91) μg/L for ripretinib and 654.74 (30.71 ∼ 1,522.48) μg/L for DP-5439, with a total median concentration of 1,129.46 (140.95 ∼ 2,981.39) μg/L in patients receiving ripretinib at 150 mg once daily. Meanwhile, using the established methods, the study conducted pharmacokinetics studies on four patients with ripretinib and DP-5439.ConclusionThis study developed and validated a robust LC-MS/MS method for determining ripretinib and its metabolite DP-5439 in human plasma. Furthermore, the practicality of this method in clinical sample analysis was demonstrated. This approach can serve as an effective tool for the pharmacokinetics analysis and therapeutic drug monitoring in patients treated with ripretinib.
Association between penicillin allergy labels and serious adverse events in hospitalized patients: a systematic review and meta-analysis
Authors: Zhang Shipeng , Dong Tianyi , Xian Jiawen , Xiao Xinyue , Yuan Jiaqing , Zeng Tong , Deng Kuan , Fu Rui , Wang Hanyu , Jiang Yanjie , Li Xueying 
Published: January 2025

BackgroundTo date, several studies have demonstrated that erroneous labeling of Penicillin allergy (PAL) can significantly impact treatment options and result in adverse clinical outcomes, while other studies have reported no negative effects. Therefore, to systematically evaluate these effects and investigate the association between adverse clinical outcomes and the Penicillin label, we conducted this meta-analysis.MethodSearches were conducted in the PubMed, Embase, Cochrane Library, and Web of Science databases from inception to 13 July 2024. The search strategy utilized terms (“antibiotic allergy label,” “penicillin allergy label,” and “allergy label”) and (“death,” “readmission,” “adverse outcome,” and “clinical adverse outcome”). In the study selection process, the PICOS framework and stringent inclusion/exclusion criteria were applied. The quality of the initially included studies was independently assessed using the Newcastle-Ottawa Scale (NOS). Data from the included studies, including relative risk (RR) and 95% confidence intervals (CI), were extracted and analyzed using Stata 16.0. Sensitivity analyses were conducted to validate the results. Heterogeneity was assessed using the I2 and Cochrane Q tests, and publication bias was evaluated using Egger’s test and funnel plot analysis.ResultsA total of 497 relevant studies were identified through four databases. Following a thorough screening process, 11 studies encompassing 1,200,785 participants were ultimately included. The combined evidence suggests that penicillin allergy labeling is associated with increased mortality RR = 1.06 (95% CI 1.06–1.07, I2 = 0.00%), acute heart failure (RR = 1.19, 95% CI 1.09–1.30, τ2 = 0.00, I2 = 92.39%), ICU events (RR = 1.10, 95% CI 1.01–1.19, τ2 = 0.00, I2 = 57.09%), and mechanical ventilation events (RR = 1.16, 95% CI 1.09–1.24, τ2 = 0.00, I2 = 23.11%). Additionally, there was no significant association with readmissions (RR = 1.05, 95% CI 0.95–1.16, I2 = 0.00%).ConclusionOur findings indicate that penicillin allergy labels are associated with an increased risk of mortality in patients, as well as being linked to acute heart failure, heightened ICU requirements, and mechanical ventilation.Systematic Review Registration:PROSPERO, identifier CRD42024571535. Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4202457153.