bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Nutrition in the First 1000 Days in the United States: A Federal Perspective
Authors: Hamner Heather C. , Nelson Jennifer M. , Sharma Andrea J. , Jefferds Maria Elena D. , Dooyema Carrie , Flores-Ayala Rafael , Bremer Andrew A. , Vargas Ashley J. , Casavale Kellie O. , de Jesus Janet M. , Stoody Eve E. , Scanlon Kelley S. , Perrine Cria G. 
Published: September 2022

The first 1000 days begins with pregnancy and ends at the child’s second birthday. Nutrition throughout the life course, and especially during the first 1000 days, supports maternal health and optimal growth and development for children.We give a high-level summary of the state of nutrition in the first 1000 days in the United States. We provide examples where continued efforts are needed.We then discuss select opportunities to strengthen federal research and surveillance, programs, and communication and dissemination efforts aimed at improving nutrition and positively, and equitably, influencing the health and well-being of mothers and children. (Am J Public Health. 2022;112(S8):S817–S825. https://doi.org/10.2105/AJPH.2022.307028 )
Laser-responsive shape memory device to program the stepwise control of intraocular pressure in glaucoma
Authors: Sung Hak-Joon , Lee Kyubae , Choi Wungrak , Kim Si Young , Oh Won Take , Park Jeongeun , Lee Chan Hee , Lee Jihei Sara , Bae Hyoung Won , Jang Dong-Su , Kim Chan Yun 
Published: September 2022

Abstract
Clinical laser systems enable user-specified control of the energy level, focus, and frequency by minimizing untargeted influences, which has never been applied to implantable shape memory polymers (SMPs). The glaucoma clinic possesses multi-decade issues to control progressive fluctuations in intraocular pressure (IOP) with tissue fibrosis upon implantation of silicone drainage devices. As a translatable device, we applied a laser-responsive SMP to develop i) a tube with intimal gel coating to release anti-fibrotic drugs and ii) safety lock ring. When the SMP tube was inserted into a silicone tube with wrapping externally by the ring, intimal gel degradation and argon laser-triggered diameter increase enabled three-step IOP control. Sustained drug release of the intimal gel suppressed tissue fibrosis, and the ring prevented late hypotonic IOP by externally squeezing the silicone tube. The unprecedented design and functions were validated using computational, in vitro, and rabbit glaucoma models by determining clinic-friendly argon laser parameters.
Trade Liberalization and Poverty in Nigeria (1981-2018): an Empirical Study.
Authors: Ogundipe Michael 
Published: September 2022

Abstract
This study looked at the effects of trade liberation on reducing poverty in Nigeria. To investigate the data properties, a number of tests were run, including co-integration, the unit-root test, and descriptive statistics. The Auto-Regressive Distributed Lag (ARDL) method was used in this study to examine the variables' short-run and long-run effects. The outcome demonstrated that trade is statistically important in determining Nigeria's poverty rate over the long and short runs. However, a country's economic system's potential to gain from economic globalization also depended on its domestic macroeconomic policy, market structure, early economic state, institutional quality, and degree of political stability. According to the predicted outcome, trade will benefit the poor in the long run. On the basis of the study's findings, suggestions are given to promote trade and lower the rate of poverty in Nigeria. To save the domestic market, Nigeria may implement a restrictive trade liberalization strategy. In contrast, the government should encourage the import of technology to advance domestic industry and adopt a soft trade liberalization policy that is based on the elimination or reduction of barriers to international commerce in technology.
JEL code: F13, F14
Clinical Benefit and Safety of Microneedle Patches Composed of Magnesium: A Pilot Study in Acne Patients
Authors: Bae Jai Hee , Noh Hyungrye , Jang Donghwi , Kim Heeyeon , Shim Joonho , Oh Se Jin , Park Jihye , Lee Jong Hee 
Published: September 2022

Abstract

Magnesium (Mg) is a newly investigated biomaterial that corrodes physiologically in water, resulting in evolved hydrogen with beneficial effects of anti-inflammation and acceleration of the wound healing process. In addition, Mg itself has anti-microbial activity against Cutibacterium acnes which play a pathogenic role in developing inflammatory acne. Based on these characteristics, the present pilot study was performed to evaluate efficacy and safety of a newly developed magnesium microneedle patch (Mg MN), with a needle length of 0.25 mm, on acne and widened pores. A total of 19 patients with mild to moderate acne and receiving no topical or oral treatment was enrolled in the study. Mg MNs were applied to inflammatory acne lesions and widened pores on both cheeks and nose. The number of acne lesions and scores improved significantly within seven days. The porphyrin level tended to decrease over 12 weeks, although pore size and sebum secretion showed unsatisfactory results. No adverse reactions were noted during the study period. In conclusion, Mg MNs can be useful in treating inflammatory acne lesions, and they are safe to use. For the improvement of widened pores, modification of needle length or a combination of topical agents may be required.
The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression
Authors: Lu Yao , Huang Panpan , Li Yanli , Liu Wenyu , Li Jing , Zhao Rui , Shi Ce , Cao Gaolu 
Published: September 2022

Abstract
Background: Osteosarcoma (OS) is the most common primary bone cancer in children and adolescents. In clinical treatments, the insensitivity of OS to conventional radiotherapy regimens significantly contributes to poor patient prognosis and survival. EXO1 is responsible for DNA repair pathways and telomere maintenance. Meanwhile, ATM and ATR are considered switches as they can regulate the expression of EXO1. However, their expression and interaction in OS cells under irradiation (IR) remains unclear. This study aimed to investigate the roles of FBXO32, ATM, ATR and EXO1 in OS radiotherapy insensitivity and poor patient prognosis and explore potential pathogenic mechanisms. Methods: Bioinformaticsmethods were employed to analyze differential gene expression and the correlations with prognosis in OS. Cell counting kit 8 assays, clone formation assays, and flow cytometry were used to evaluate cell survivaland apopotosisunder IR. Co-IP assays detected protein-protein interactions. Results: Bioinformatics analysis revealed that EXO1 is closely related to the survival, apoptosis and poorer prognosis in OS. The silencingof EXO1 suppressed cell proliferation and increased the sensitivity of OS cells. Molecular biological experiments showed that the ATMand ATR acted as the switch to regulate EXO1 expression under IR. Conclusion: Higher expression of EXO1, which was closely correlated with IR insensitivity and poorer prognosis, might be used as a prognostic indicator for OS. Phosphorylated-ATM enhanced the expression of EXO1, and phosphorylated-ATR induced the degradation of EXO1. More importantly, FBXO32 degraded ATR via ubiquitination in time dependent. Our data may provide a reference for future research on mechanisms, clinical diagnosis, and treatment of OS.
Expression of SLC25A18 is positively correlated with Alzheimer's disease
Authors: Song Jiayi , Jia Yong , Han Hao , Yang Xue-Han , Zhang Jing , Zhang Mei-Shuang , Liu Jing-Yue , Zhang Qiang , Wang Su-Shan , Wang Chun-Yan , Chen Li , Zhang Ming 
Published: September 2022

Abstract
Background: According to research, the neurotoxicity caused by the accumulation of the excitatory neurotransmitter glutamate is closely related to Alzheimer's disease. However, even after 50 years of research, little is known about the relationship between glutamate-related carriers and Alzheimer's disease, and it is unclear whether glutamate metabolism target genes are involved in the occurrence and development of AD.As a result, the goal of our investigations was to identify glutamate metabolism target genes involved in the onset and progression of AD, as well as to validate and mine the relationship between them.
Results: In this paper, we analysed the Gene Expression Omnibus (GEO) data further and discovered that the expression of glutamate carrier SLC25A18 is correlated with Alzheimer's disease by screening the differential genes in different regions of the brain of Alzheimer's disease patients. To verify the expression of SLC25A18 during Alzheimer's disease development, we created animal models (5×FAD transgenic AD animal model, chemically induced AD animal model, natural ageing animal model), and the results showed that the expression of SLC25A18 increased when Alzheimer's disease occurred in various animal models. After that, we checked the expression of SLC25A18 in Aβ1-42-induced Neuro 2A cells, and the results revealed that neurons had higher SLC25A18 expression after Aβ1-42 induction.
Conclusions: The results indicate that SLC25A18 is related to the onset and progression of Alzheimer's disease and that it could be a target for treatment.
Effects of Hesperidin on Oestrus Synchronisation and Fertility Parameters in Thermally Stressed Yankasa Ewes
Authors: Saayinzat Francis Elisha , Ogwu D. 
Published: September 2022

Abstract

Hesperidin is an exogenous antioxidant obtained from citrus fruits. Recent studies have demonstrated its therapeutic and biological properties in ameliorating oxidative stress through scavenging for free radical species. The study was aimed at evaluating the effect of hesperidin on oestrus synchronisation and fertility parameters in thermally stressed Yankasa ewes. The study was carried out during the dry and hot seasons of the year in Vom, Plateau State, Nigeria. Forty-six (46) maiden Yankasa ewes with average body condition score of 2.5 and aged between 5–8 months, weighed between 15–20 kg were randomly allocated into two groups of twenty-seven ewes each. Group A served as the treatment group, which were given oral hesperidin supplement (200 mg/kg body weight) on a weekly basis throughout the experiment. Group B severed as the control animals, which received 10 mL of mix dimethyl sulphate and normal saline throughout the study. Three rams aged 18 months to 2 years, weighing between 35–40kg were used as teaser and breeding rams. The time of onset of oestrus, oestrus duration, oestrus response rate, control internal drug release retention rate, pregnancy and lambing rates, fecundity, gestational length, lambing weight and postpartum oestrus interval were evaluated. The results obtained showed that hesperidin had significant (P < 0.05) effects on the CIDR retention (95 7.10% and 75.0 ± 7.1%), oestrus response rate (ORR) (80.00 ± 14.1% and 65.0 ± 7.1%), onset of oestrus (2.8 ± 1.0 and 6.0 ± 1.4 days), duration of oestrus (30.5 ± 2.1 and 25.6 ± 2.4 hours), pregnancy rate (85% and 75%), lambing rate (95% and 80%), lambing weight (2.52 ± 0.69 kg and 2.24 ± 0.73), postpartum oestrus interval (37.88 ± 1.13 and 39.33 ± 0.67 days), and gestation length (149.38 ± 1.39 and 151.4 ± 1.14 days) for the treatment and control groups respectively. The present study demonstrated that hesperidin administration increased significantly (P < 0.05) the TOO, ORR, OD, CIDR retention, lambing weight, pregnancy and lambing rates in thermally stressed Yankasa ewes.
Effect of Bifidobacterium bifidum G9-1 on fecal short chain fatty acids in patients with chronic constipation: a multicenter, observational study
Authors: Ogata Tomoki , Kessoku Takaomi , Jono Tsumugi , Kasai Yuki , Ozaki Anna , Tanaka Kosuke , Takahashi Kota , Yamamoto Atsushi , Iwaki Michihiro , Kobayashi Takashi , Yoshihara Tsutomu , Misawa Noboru , Kato Shingo , Higurashi Takuma , Hosono Kunihiro , Yoneda Masato , Kobayashi Noritoshi , Iwasaki Tomoyuki , Kurihashi Takeo , Nakatogawa Machiko , Oyamada Shunsuke , Nakajima Atsushi 
Published: September 2022

Abstract
Background and aim:
Bifidobacterium bifidum G9-1 (BBG9-1) is a probiotic and is considered to be useful for constipation. However, the effect of BBG9-1 on short-chain fatty acids (SCFAs) in constipated patients has not been reported. The purpose of this study was to investigate the association between BBG9-1 and SCFA.
Methods
This is a prospective four-center observational study. Patients with constipation were treated with BBG9-1 at 72 mg/day for 8 weeks after a 2-week baseline period. Patients with constipation were defined as those diagnosed with Rome IV criteria. The primary endpoint was the concentration of SCFA in feces. Secondary endpoints included change in the Japanese version of the Japanese Patient Assessment of Constipation Composite Index (JPAC-QOL), frequency of bowel movements, stool form, sense of incomplete evacuation, and straining.
Results
In the 87 patients analyzed, n-butyric acid, iso-butyric, and acetic acid increased with respect to fecal SCFA concentrations. The Japanese version of the Japanese Patient Assessment of Constipation Composite Index score, frequency of bowel movements, stool form, sense of incomplete evacuation, straining also improved.
Conclusion
The study showed that 8 weeks of oral administration of BBG9-1 increased SCFA concentrations in the feces, especially acetic and butyric acids.
Manganese catalyzed acceptorless dehydrogenative borylation of styrenes
Authors: Das Kuhali , Kundu Abhishek , Adhikari Debashis , Maji Biplab 
Published: September 2022

Abstract
Alkenyl boronate esters are important synthons for various pharmaceuticals, agrochemicals, natural products, and material science. Direct alkene sp2 C-H bond borylation is highly valued for its synthesis. However, the drawbacks associated with chemo-, regio- and stereoselectivity, using late transition metal catalysts, and the need for sacrificial hydrogen scavengers impeded its practicability and sustainability. Herein, we utilized a 3d metal complex as a catalyst for synthesizing alkenyl boronate esters via the dehydrogenative coupling of styrenes and pinacolborane. Hydrogen gas is produced as the sole byproduct without needing an acceptor, making the process green and atom-economical. The methodology depicted excellent selectivity towards dehydrogenative borylation over direct hydroboration. Borylation of aromatic alkenes over aliphatic ones was also noticed. Derivatives of natural products and bioactive molecules underwent successful diversification. The product alkenyl boronate esters could be employed for synthesizing several drugs and potential anticancer agents. Thorough experimental and high-level computational studies were performed to delineate the reaction pathway. The hemilability and metal-ligand bifunctionality of the ligand backbone was found to be crucial for successful catalytic turnover.
The effect of various flavorings on PAHs level in the shell and kernel of roasted sunflower seeds
Authors: gilani Parisa Shavali , Yazdanfar Najmeh , Khaniki Gholamreza Jahed , aghaee Ebrahim Molaee , sadighara parisa 
Published: September 2022

Abstract
Background: Amount of PAHs can be reduced by various methods, such as food additives. The effects of different flavors were investigated on the formation of carcinogenic and non-carcinogenic poly aromatic hydrocarbons (PAHs) in the shell and kernel of roasted sunflower seeds.
Methods: Samples were prepared in the shell and kernel of 10 types of sunflowers with flavors of lemon, golpar (hogweed), salt, ketchup and raw samples was performed with conventional solvent extraction by Soxhlet. Measuring and determining the amount of PAHs was analyzed by GC/MS.
Results: The PAHs of sunflower seeds were in the range of 0.4_3.2 ppm. The lowest amount was related to hogweed kernel and the highest amount was related to lemon shell.
Conclusion: Roasting process could result in contamination of sunflower seeds, especially the shell of seeds. Also, various flavors such as hogweed due to their antioxidant properties can affect the amount of PAHs. In addition, the excessive reduction of pH due to the oxidation of fats does not have a decreasing effect on the amount of PAHs. As a result, this amount was observed in lemon juice more than other flavors in shell.
Etlingera hemisphaerica Blume attenuates male reproductive toxicity due to mercury chloride in Mus musculus
Authors: Ruyani Aceng , Muthmainnah Dinisari , Simatupang Melly Boru , Ramadhanti Annisa P. , Putri Sylvia R. , Parlindungan Deni 
Published: September 2022

Abstract
This study evaluated the effects of leaf ethanolic extract Etlingera hemisphaerica Blume (LE3H) on male reproductive toxicity due to mercury chloride (HgCl2) in Mus musculus (mice). Those were three test materials; 5 mg/kg body weight (bw) HgCl2, 0.2 mg/gbw Immunos®, and 0.13, 0.26, 0.39 mg/gbw LE3H. On day 1 (d-1), four groups of 5 mice were given HgCl2 by gavage, and then on d-3, d-5, and d-7 days, three groups were administered 0.13, 0.26, and 0.39 mg/gbw of LE3H, another group as control. On d-16, the animals were killed using the cervical dislocation method for observing their testicular morphometrics. Three groups of 9 mice were given HgCl2 by injected on d-1, and then on d-4 one group was administered Immunos® and one group was administered a determined LE3H, another group as control, and then were killed on d-7 for measuring glucose and malondialdehyde (MDA). Two groups of 15 mice were injected with HgCl2 on d-1, and then on d-3, one group was administrated by the determined LE3H, another group as control, and then were killed on d-6 for investigating sperms quality. Results revealed that HgCl2 increased the weight, length, and diameter of the testes compared to the control, while HgCl2 + LE3H three times tended to restore testes similar to the control. A dose of LE3H (0.39 mg/gbw) was effective in testicular recovery conditions. HgCl2 increased blood glucose dan MDA levels compared to the control. The blood glucose dan MDA level on HgCl2 + Immunos® and HgCl2 + LE3H did not differ from the control. HgCl2 decreased sperm concentration compared to the control. HgCl2 + LE3H was lower than HgCl2 and approach the control. Sperm moves fast and straight in the control, HgCl2, and HgCl2 + LE3H were 30.63; 16.12; and 27.62% respectively. Thus, LE3H attenuates male reproductive toxicity duo to HgCl2 in mice.
A nonlinear dynamic reduction solver for complex jointed structures having hysteresis contact behaviour
Authors: Wang Dong 
Published: September 2022

Abstract
A novel nonlinear dynamic reduction method was developed to determine the steady-state vibration responses of complex jointed structures having hysteresis contact behaviour. By using harmonic balance method to reformulate the nonlinear dynamic equilibrium equations into a set of nonlinear algebraic ones, a dynamic reduction strategy of local nonlinearity transformation was theoretically developed to iterate nonlinear solutions in the coordinate associated with the degree of freedoms of the nonlinear joints. Only odd-order harmonic components were truncated to approximate the hysteresis nonlinear contact forces of the joint interfaces, as this approach was conducive to the further dimension reduction of nonlinear algebraic equations and iteration matrix. Then, a nonlinear dynamic reduction solver was developed to bridge the steady-state nonlinear vibration responses of the overall structure with the dynamic characteristics of the underlying linear substructures, nonlinear joint models and external excitations. Combined with the finite element analysis, the steady-state nonlinear vibration responses of a complex assembled structure with four reduced-order nonlinear joint models were numerically simulated to validate the proposed nonlinear dynamic reduction method. The comparative results shown a good agreement with the literature work, and indicated a great higher computational efficiency. The experimental investigations of a rubber isolator system were also performed to validate the proposed method, and presented a good performance.
How to reduce empathic distress and increase emotional skills in medical training? Experience of a Mindfulness-Based stress reduction class vs. control group in France
Authors: Brami Cloe , Zenasni Franck , Hettal Liza , Pasquier Florence , Sultan Serge 
Published: September 2022

Abstract
Background: Improving student wellness through curricular activities is a topic of interest in medical school. Both distress and well-being are related to medical student empathy. Numerous data suggest that learning mindfulness skills help to reduce anxiety, stress and overall psychological distress. Moreover, there are still poor data on the impact of MBSR on medical students' empathy and emotional skills.
Methods: We designed a controlled study including an intervention group (MBSR) and a wait-list control group. We aimed to explore the impact of an MBSR training in medical students on (1) empathy (2) emotional skills (identification, understanding, acceptance) and (3) self-care. Online assessments occurred at baseline and post intervention. We analyzed pre-post changes and explored intervention effects using a generalized mixed model.
Results: Fifty-one medical students were included. 80% of students attended all MBSR classes. When compared with the control group, Personal Distress (PD) of the empathy subscale decreased significantly in the MBSR group (β=-3.55 [95%CI -5.09, -1.40], p<0.005). No other significant change was observed as for the empathy subscales. Students in the MBSR group increased their emotional skills as the ability to identify (p<.005, Cohen’s d=0,52) and understand (p=.02, Cohen’s d=0.62) one’s own emotion. The total Self-Compassion score (SCS) increased significantly in the MBSR group (β=-25.5 [95%CI 18.16, 32.86], p<0.001) assesses the ability to self-care.
Conclusion: Results suggest that MBSR develops medical students' interpersonal resources and reduces empathy distress. Indeed, PD assesses the tendency to feel distress and discomfort in response to the distress of others and corresponds to a challenge in medical training. MBSR could be beneficially combined with other educational modalities to enhance each component of empathy.
Phishing URL Detection Using CNN-LSTM and Random Forest Classifier
Authors: Nepal Sopnil , Gurung Hemant , Nepal Roshan 
Published: September 2022

Abstract
This paper presents the classification of phishing URL's apart from legitimate URL's with the use of machine learning and deep learning techniques. Phishing is defined as an act to steal the private information by pretending to be a legitimate entity which they are not. Machine learning model, Random Forest classifier is trained on the extracted features based on Address Bar, Domain and HTML and JavaScript of the URL. On the other hand, CNN-LSTM hybrid model was trained to learn the character sequence features of the given URL and make the classification. The dataset used was public data from Kaggle which was downloaded from their website. The dataset contained 11,430 URLs: 5,715 legitimate URLs and 5,715 phishing URL. Hereafter, we classified the URL of the current address bar as legitimate or phishing with the use of previously trained model. Thus, proposed paper focuses on the study and development of models for detection of phishing sites so that properties of various URLs can be learnt by feature extraction and can be classified as accurately as possible.