bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive Role of CD36 Expression in HER2-Positive Breast Cancer Patients Receiving Neoadjuvant Trastuzumab
Authors: Ligorio Francesca , Di Cosimo Serena , Verderio Paolo , Ciniselli Chiara Maura , Pizzamiglio Sara , Castagnoli Lorenzo , Dugo Matteo , Galbardi Barbara , Salgado Roberto , Loi Sherene , Michiels Stefan , Triulzi Tiziana , Tagliabue Elda , El-Abed Sarra , Izquierdo Miguel , de Azambuja Evandro , Nuciforo Paolo , Huober Jens , Moscetti Luca , Janni Wolfgang , Coccia-Portugal Maria Antonia , Corsetto Paola Antonia , Belfiore Antonino , Lorenzini Daniele , Daidone Maria Grazia , Vingiani Andrea , Gianni Luca , Pupa Serenella Maria , Bianchini Giampaolo , Pruneri Giancarlo , Vernieri Claudio 
Published: July 2022

Abstract

Background
Despite huge efforts to identify biomarkers associated with long-term clinical outcomes in patients with early-stage HER2-positive breast cancer (HER2+ BC) treated with (neo)adjuvant anti-HER2 therapy, no reliable predictors have been identified so far. Fatty acid uptake, a process mediated by the transmembrane transporter CD36, has recently emerged as a potential determinant of resistance to anti-HER2 treatments in preclinical HER2+ BC models.

Methods
Here, we investigated the association between baseline intratumor CD36 gene expression and event-free survival in 180 patients enrolled in the phase III trial Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimization (NeoALTTO), which randomly assigned stage II-III HER2+ BC patients to receive neoadjuvant lapatinib, trastuzumab, or lapatinib-trastuzumab in combination with chemotherapy. To this aim, we selected NeoALTTO trial patients for whom pretreatment whole transcriptomic data were available. The main study results were validated in an independent cohort of patients enrolled in the neoadjuvant phase II trial NeoSphere.

Results
In 180 NeoALTTO patients, high intratumor CD36 expression was independently associated with worse event-free survival in patients treated with trastuzumab-based therapy (hazard ratio [HR] = 1.72, 95% confidence interval [CI] = 1.20 to 2.46), but not with lapatinib-based (HR = 1.02, 95% CI = 0.68 to 1.53) or trastuzumab-lapatinib–based (HR = 1.08, 95% CI = 0.60 to 1.94) therapy. Among 331 NeoSphere patients evaluated, high CD36 expression was independently associated with worse patient disease-free survival in both the whole study cohort (HR = 1.197, 95% CI = 1.002 to 1.428) and patients receiving trastuzumab-based neoadjuvant therapy (HR = 1.282, 95% CI = 1.049 to 1.568).

Conclusions
High CD36 expression predicts worse clinical outcomes in early-stage HER2+ BC treated with trastuzumab-based neoadjuvant therapy.
IRONMAN peptide interacts with OsHRZ1 and OsHRZ2 to maintain Fe homeostasis in rice
Authors: Peng Feng , Li Chenyang , Lu Chengkai , Li Yang , Xu Peng , Liang Gang 
Published: July 2022

AbstractIRONMAN (IMA) is a family of small peptides which positively regulate plant responses under Fe deficiency. However, the molecular mechanism by which OsIMA1 and OsIMA2 regulate Fe homeostasis in rice is unclear. Here, we reveal that OsIMA1 and OsIMA2 interact with the potential Fe sensors, OsHRZ1 (HAEMERYTHRIN MOTIF-CONTAINING REALLY INTERESTING NEW GENE (RING) AND ZINC-FINGER PROTEIN 1) and OsHRZ2. OsIMA1 and OsIMA2 contain a conserved 17 amino acid C-terminal region which is responsible for the interactions with OsHRZ1 and OsHRZ2. Plants overexpressing OsIMA1 (OsIMA1ox) show increased Fe concentration in seeds and reduced fertility, as observed in the hrz1-2 loss-of-function mutant plants. Moreover, the expression patterns of Fe deficiency inducible genes in the OsIMA1ox plants are the same as those in hrz1-2. Co-expression assays suggest that OsHRZ1 and OsHRZ2 promote the degradation of OsIMA1 proteins. As the interaction partners of OsHRZ1, the OsPRI (POSITIVE REGULATOR OF IRON HOMEOSTASIS) proteins also interact with OsHRZ2. The conserved C-terminal region of four OsPRIs contributes to the interactions with OsHRZ1 and OsHRZ2. An artificial IMA (aIMA) derived from the C-terminal of OsPRI1 can be also degraded by OsHRZ1. Moreover, aIMA overexpressing rice plants accumulate more Fe without reduction of fertility. This work establishes the link between OsIMAs and OsHRZs, and develops a new strategy for Fe fortification in rice.
Eating Disorders in U.S. Active Duty Military Members and Veterans: A Systematic Review
Authors: Touma Danielle A , Quinn Meghan E , Freeman Vanessa E , Meyer Eric G 
Published: July 2022

ABSTRACT

Introduction
Feeding and eating disorders can be difficult to treat and frequently co-occur with other mental health conditions. The last systematic review of eating disorders in a military and veteran population was published in 2015. An updated review is warranted to re-examine the current literature on eating disorders in the active duty and veteran populations.

Materials and Methods
A systematic review that described the prevalence, co-occurrence of other disorders and/or events, and health care utilization of U.S. active duty members and veterans was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Databases and Medical Subject Headings (MeSH) terms used are listed in Appendix A. Each category of the literature was extracted and graded using the Oxford Centre for Evidence-Based Medicine Levels of Evidence.

Results
Twenty-one studies revealed prevalence estimates with varying rates based on demographic information. Trauma exposure is consistently associated with eating disorder development. Individuals diagnosed with eating disorders had greater health care utilization.

Conclusions
Research on eating disorders in the military and veteran populations has expanded in recent years. Limitations of the evidence included in this review stem from the use of self-reported questionnaires, changes to medical record systems, and limited generalizability to the overall population of patients with eating disorders. Further research should investigate the impact of demographic factors and trauma exposure on the development of an eating disorder within the military and veteran populations.
SDSS-IV MaNGA – gas rotation velocity lags in the final sample of MaNGA galaxies
Authors: Bizyaev Dmitry , Walterbos Rene A M , Chen Yan-Mei , Drory Niv , Lane Richard R , Brownstein Joel R , Riffel Rogemar A 
Published: July 2022

ABSTRACT
We consider the largest sample of 561 edge-on galaxies observed with integral field units by the MaNGA survey and find 300 galaxies where the ionized gas shows a negative vertical gradient (lag) in its rotational speed. We introduce the stop altitude as the distance to the galactic mid-plane at which the gas rotation should stop in the linear approximation. We find correlations between the lags, stop altitude and galactic mass, stellar velocity dispersion, and overall Sersic index. We do not find any correlation of the lags or stop altitude with the star formation activity in the galaxies. We conclude that low-mass galaxies (log(M*/M⊙) &lt; 10) with low-Sersic index and with low-stellar velocity dispersion possess a wider ‘zone of influence’ in the extragalactic gas surrounding them with respect to higher mass galaxies that have a significant spherical component. We estimated the trend of the vertical rotational gradient with radius and find it flat for most of the galaxies in our sample. A small subsample of galaxies with negative radial gradients of lag has an enhanced fraction of objects with aged low-surface brightness structures around them (e.g. faint shells), which indicates that noticeable accretion events in the past affected the extraplanar gas kinematics and might have contributed to negative radial lag gradients. We conclude that an isotropic accretion of gas from the circumgalactic medium plays a significant role in the formation of rotation velocity lags.
Constraining the reionization and thermal history of the Universe using a seminumerical photon-conserving code script
Authors: Maity Barun , Choudhury Tirthankar Roy 
Published: July 2022

ABSTRACT
Given that the reionization history of cosmic hydrogen is yet to be stringently constrained, it is worth checking the prospects of doing so using physically motivated models and available observational data. For this purpose, we use an extended version of the explicitly photon-conserving seminumerical model of reionization, script, which also includes thermal evolution of the intergalactic medium (IGM). The model incorporates the effects of inhomogeneous recombination and radiative feedback self-consistently and is characterized by five free parameters (two for the redshift-dependent ionization efficiency, two for the ionizing escape fraction, and another for reionization temperature increment). We constrain these free parameters by simultaneously matching with various observational probes, e.g. estimates of the ionized hydrogen fraction, the CMB scattering optical depth and the galaxy UV luminosity function. In addition, we include the low-density IGM temperature measurements obtained from Lyman-α absorption spectra at z∼5.5, a probe not commonly used for Bayesian analysis of reionization parameters. We find that the interplay of the various data sets, particularly inclusion of the temperature data, leads to tightening of the parameter constraints. Our default models prefer a late end of reionization (at z ≲ 6), in agreement with other recent studies. We can also derive constraints on the duration of reionization, $\Delta z=1.81^{+0.51}_{-0.67}$ and the mid-point of reionization, $z_{\mathrm{mid}}=7.0^{+0.30}_{-0.40}$. The constraints can be further tightened by including other available and upcoming data sets.
Molecular survey of Cryptoplax japonica (Polyplacophora: Cryptoplacidae) reveals cryptic lineages in the northwestern Pacific
Authors: Park Jina , Lee Yucheol , Kim Taeho , Kern Elizabeth , Kil Hyun-Jong , Eernisse Douglas J , Saito Hiroshi , Park Joong-Ki 
Published: July 2022

ABSTRACT
The chiton genus Cryptoplax is widely distributed in the Indo-Pacific, extending to southern Australia and the northwestern Pacific (NWP), with 17 recognized species. Among these species, Cryptoplax japonica is commonly found on rocky intertidal and subtidal substrates in the NWP, whereas another species, C. propior, is rarely seen because of its cryptic subtidal habitat and limited distribution. In this study, we surveyed the genetic diversity of C. japonica populations based on 93 individuals from 24 sampling sites along the Korean and Japanese coastlines, including the type locality, using DNA sequences of the mitochondrial gene cytochrome c oxidase subunit I (COI). Haplotype network and phylogenetic analyses of COI sequences revealed two highly divergent genetic lineages of C. japonica separated by a large pairwise genetic distance (10.62%), which was comparable to the genetic difference when either of these two lineages (A or B) is compared with the co-occurring C. propior. In addition to COI sequences, average sequence divergence in 16S rDNA between these three lineages ranged from 2.0 to 3.3%. In contrast to this deep sequence divergence, both morphological examination of radula, girdle and articulamentum colouring, and morphometric analyses of shell measurements using principal component analysis and linear discriminant analysis revealed no diagnostic differences between the two C. japonica lineages. The co-occurrence of these two divergent lineages within most of our studied area, with no morphological differences, indicates cryptic divergence. More extensive sampling from the entire distributional ranges of these cryptic species, in combination with the use of additional molecular markers could shed light on the mechanisms underlying their divergence.
Smoking Cessation in People With and Without Diabetes After Acute Coronary Syndrome
Authors: Clement Ludivine , Gencer Baris , Muller Olivier , Klingenberg Roland , Räber Lorenz , Matter Christian M , Lüscher Thomas F , Windecker Stephan , Mach François , Rodondi Nicolas , Nanchen David , Clair Carole 
Published: July 2022

Abstract

Introduction
People with diabetes smoke at similar rates as those without diabetes, with cardiovascular consequences. Smoking cessation rates were compared between people with and without diabetes 1 year after an acute coronary syndrome (ACS).

Aims and Methods
People with ACS who smoked and were part of an observational prospective multicenter study in Switzerland were included from 2007 to 2017 and followed for 12 months. Seven-day point prevalence abstinence was assessed at 12 months follow-up. Association between diabetes and smoking cessation was assessed using multivariable-adjusted logistical regression model.

Results
2457 people with ACS who smoked were included, the mean age of 57 years old, 81.9% were men and 13.3% had diabetes. At 1 year, smoking cessation was 35.1% for people with diabetes and 42.6% for people without diabetes (P-value .01). After adjustment for age, sex, and educational level, people with diabetes who smoked were less likely to quit smoking compared with people without diabetes who smoked (odds ratio [OR] 0.76, 95% confidence interval [CI] 0.59–0.98, P-value = .037). The multivariable-adjusted model, with further adjustments for personal history of previous cardiovascular disease and cardiac rehabilitation attendance, attenuated this association (OR 0.85, 95% CI 0.65–1.12, P-value = .255). Among people with diabetes, cardiac rehabilitation attendance was a positive predictor of smoking cessation, and personal history of cardiovascular disease was a negative predictor of smoking cessation.

Conclusions
People with diabetes who smoke are less likely to quit smoking after an ACS and need tailored secondary prevention programs. In this population, cardiac rehabilitation is associated with increased smoking cessation.

Implications
This study provides new information on smoking cessation following ACSs comparing people with and without diabetes. After an ACS, people with diabetes who smoked were less likely to quit smoking than people without diabetes. Our findings highlight the importance of tailoring secondary prevention to people with diabetes.
Proteomics reveals differential adsorption of angiogenic platelet lysate proteins on calcium phosphate bone substitute materials
Authors: da Costa Marques Richard , Simon Johanna , d’Arros Cyril , Landfester Katharina , Jurk Kerstin , Mailänder Volker 
Published: July 2022

Abstract
Protein adsorption on biomaterials for bone substitution, such as calcium phosphates (CaP), evokes biological responses and shapes the interactions of biomaterials with the surrounding biological environment. Proteins adsorb when CaP materials are combined with growth factor-rich hemoderivatives prior to implantation to achieve enhanced angiogenesis and stimulate new bone formation. However, the identification of the adsorbed proteins and their angiogenic effect on bone homeostasis remain incompletely investigated. In this study, we analyzed the adsorbed complex protein composition on CaP surfaces when using the hemoderivatives plasma, platelet lysate in plasma (PL), and washed platelet lysate proteins (wPL). We detected highly abundant, non-regenerative proteins and anti-angiogenic proteins adsorbed on CaP surfaces after incubation with PL and wPL by liquid chromatography and mass spectrometry (LC–MS) proteomics. Additionally, we measured a decreased amount of adsorbed pro-angiogenic growth factors. Tube formation assays with human umbilical endothelial cells demonstrated that the CaP surfaces only stimulate an angiogenic response when kept in the hemoderivative medium but not after washing with PBS. Our results highlight the necessity to correlate biomaterial surfaces with complex adsorbed protein compositions to tailor the biomaterial surface toward an enrichment of pro-angiogenic factors.
Albumin-assembled copper-bismuth bimetallic sulfide bioactive nanosphere as an amplifier of oxidative stress for enhanced radio-chemodynamic combination therapy
Authors: Tao Weiyong , Tuo Zhan , Wu Feige , Mu Ketao , Xu Cunjing , Shi Yuxiao , Sun Zeyu , Wang Yifan , Li Yan , Zhong Zhenyu , Zhou Lei , Wang Jianglin , Liu Jie , Du Yingying , Zhang Shengmin 
Published: July 2022

Abstract
The tumor microenvironment with overexpressed hydrogen peroxide (H2O2) and reinforced antioxidative system (glutathione, GSH) becomes a double-edged sword for the accessibility of nano-therapy. Since reactive oxygen species (ROS) are easily quenched by the developed antioxidative network, ROS-based treatments such as chemodynamic therapy (CDT) and radiotherapy (RT) for killing cancer cells are severely attenuated. To overcome such limitations, a bioactive nanosphere system is developed to regulate intracellular oxidative stress for enhanced radio-chemodynamic combination therapy by using bovine serum albumin (BSA) based bioactive nanospheres that are BSA assembled with in situ generated copper-bismuth sulfide nanodots and diallyl trisulfide (DATS). The copper-bismuth sulfide nanodots react with H2O2 to produce •OH and release Cu2+. Then, the Cu2+ further depletes GSH to generate Cu+ for more •OH generation in the way of Fenton-like reaction. Such a cascade reaction can initiate •OH generation and GSH consumption to realize CDT. The elevation of ROS triggered by the DATS from BBCD nanospheres further augments the breaking of redox balance for the increased oxidative stress in 4T1 cells. With the sensitization of increased oxidative stress and high Z element Bi, an enhanced radio-chemodynamic combination therapy is achieved. The current work provides an enhanced radio-chemodynamic combination treatment for the majority of solid tumors by using the co-assembled bioactive nanospheres as an amplifier of oxidative stress.
Understanding Loneliness and Social Exclusion in Residential Centers for Social Inclusion
Authors: Arnoso Martínez Ainara , Pizarro Pacheco Maribel , Arnoso Martínez Maitane , Asla Alcibar Nagore , Elgorriaga Astondoa Edurne 
Published: July 2022

Abstract
Loneliness and social isolation are widely recognized as one of the most important and deep-rooted problems facing society, with special impact on people who are immersed in processes of social exclusion. The study examined the relationship between loneliness and social exclusion in residential centers. It used phenomenological interviews (N = 11) to explore the subjective experiences of loneliness among people in residential centers for social inclusion to determine the variables associated with their emergence and development, as well as the factors aggravating or alleviating the influence of loneliness on their lives. The results yielded five themes associated with the loneliness of residents, with an interweaving of different axes of exclusion: (1) loneliness and unfulfilled need for meaningful relationships; (2) family losses and conflicts; (3) the experiences of homelessness and residential centers; (4) the economic dependence, contribution, and social inclusion; and (5) the loneliness associated with marginalization and social stigma. Authors present the implications of these findings on social work and some lines of psychosocial intervention.
Trauma-Informed Pedagogy to Foster Resilience in Graduate Nursing Education
Authors: Thompson Christina N. , Otts Jo Ann A. , Stuart Wilma P. , McMullan Taralyn W. , Williams David S. 
Published: July 2022

Abstract
The experiences of graduate nursing students during the COVID-19 pandemic necessitate a trauma-informed approach to education. Three hundred graduate nursing students responded to a discussion assignment in a doctoral-level health care policy course. Thematic analysis identified common themes of fear, anxiety, frustration, and exhaustion (n = 93). Conflict and strain were identified in relation to all major roles (provider, student, and family member), ultimately creating physical and mental barriers to fulfilling each of the roles. Curricular standards must maintain rigor while incorporating flexibility into design standards to assist students when faced with trauma or crisis.
Pandemic Adaptations to an Honors Program Inaugural Capstone Projects
Authors: Crespo-Fierro Michele 
Published: July 2022

Abstract
The COVID-19 pandemic and public health response of the US health care system and government provided unique opportunities for nursing education as it disrupted the usual mode of operation. An honors program at a private university at the epicenter of the pandemic pivoted multiple times to avoid failing to support the capstone projects of its inaugural cohort. Collaborative outreach with mentors and instructional technologists created opportunities for virtual delivery of patient and nursing student education and program evaluation. The lessons learned became part of the roster of resources for future cohorts to sustainably design and deliver their capstone projects.
The Effects of Disaster Nursing Education Program on Beliefs in General Disaster Preparedness, Disaster Response Self-Efficacy, and Psychological Resilience in Nursing Students
Authors: Çiriş Yildiz Cennet , Yildirim Dilek 
Published: July 2022

Abstract

AIM
This study was conducted to evaluate the effects of a disaster nursing and management education program on beliefs in general disaster preparedness, disaster response self-efficacy, and psychological resilience in nursing students.

METHOD
The sample consisted of nursing students receiving undergraduate education in Istanbul, Turkey. Participants were randomly divided into the intervention (n = 65) and control (n = 66) groups. The intervention group was given an eight-module education program with theoretical and applied components. Data were collected using the Belief in General Disaster Preparedness Scale, the Disaster Response Self-Efficacy Scale, and the Brief Resilience Scale.

RESULTS
The mean Belief in General Disaster Preparedness Scale, Disaster Response Self-Efficacy Scale, and Brief Resilience Scale scores of the intervention group were higher than those of the control group.

CONCLUSION
The disaster nursing and management education program provided to nursing students was determined to increase beliefs in general disaster preparedness, disaster response self-efficacy, and psychological resilience.
Not all benign: disease course, complications, and sequalae of chronic recurrent multifocal osteomyelitis in children
Authors: Yasin Shima , Sato T. Shawn , Ferguson Polly 
Published: July 2022

Purpose of review
Advances in pathogenesis of chronic recurrent multifocal osteomyelitis in children (CRMO) have shaped therapeutic strategies. The use of whole-body MRI (WBMRI) and improved awareness of CRMO has increased rates and timeliness of CRMO diagnoses. In this review, we highlight the findings from recently published CRMO cohorts and describe the course, complications, and long-term sequalae of CRMO. It is important for clinicians to be aware of the potential for long-term sequelae in order to optimize therapy and avoid complications.

Recent findings
Despite recent advances in defining disease pathogenesis, children with CRMO continue to suffer from complications and deformities. Involvement of the spine can be asymptomatic and is not as rare as previously suggested. This can result in damaging outcomes, such as vertebral fractures and permanent deformities. A subset of patients has polycyclic disease course and some continue to have active disease for years and well into adulthood, with significant impacts on quality of life.

Summary
These recent findings have considerable implication on clinical practice regarding diagnosis, treatment, and monitoring of the disease. Collectively, they support the need for continued monitoring of the disease and screening using comprehensive imaging, such as WBMRI.