bluuebunny/crossref_metadata_2025_split huggingface dataset:
Active noise reduction analysis and experimental research on electromagnetic vibration noise of transformer
Authors: Liu Zhao , Zhu Lihua , Zhong Sichong , Wang Yanzhao , Zhang Jiangong 
Published: April 2022

Active noise reduction system is widely used in production and life because of its good noise reduction effect in low frequency band, easy installation, high practicability and good economy. This paper focused on the compilation of active noise reduction algorithms and the overall system debugging, and explored the factors that affected the active noise reduction. In order to realize the software part of the active noise reduction system, the LMS adaptive filtering algorithm was written and non-linearity function and auxiliary machine learning algorithm was used. Then the hardware system was built for the overall joint debugging of software and hardware. Combined with the practical application background of electrical equipment engineering, the influence of the angle, number of speakers and the distance from electrical equipment on the noise reduction effect were studied. The results showed the overall noise reduction in the experiment was about 6 dB, which proved that the active noise reduction system proposed in this paper is effective.
A Single mtDNA Deletion in Association with a LMNA Gene New Frameshift Variant: A Case Report
Authors: Montano Vincenzo , Mancuso Michelangelo , Simoncini Costanza , Torri Francesca , Chico Lucia , Ali Greta , Rocchi Anna , Baldinotti Fulvia , Caligo Maria Adelaide , Lattanzi Giovanna , Mattioli Elisabetta , Cenacchi Giovanna , Barison Andrea , Siciliano Gabriele , Ricci Giulia 
Published: April 2022

Background: Proximal muscle weakness may be the presenting clinical feature of different types of myopathies, including limb girdle muscular dystrophy and primary mitochondrial myopathy. LGMD1B is caused by LMNA mutation. It is characterized by progressive weakness and wasting leading to proximal weakness, cardiomyopathy, and hearth conduction block. Objective: In this article, we describe the case of a patient who presented with limb-girdle weakness and a double trouble scenario –mitochondrial DNA single deletion and a new LMNA mutation. Methods: Pathophysiological aspects were investigated with muscle biopsy, Western Blot analysis, NGS nuclear and mtDNA analysis and neuromuscular imaging (muscle and cardiac MRI). Results: Although secondary mitochondrial involvement is possible, a “double trouble” syndrome can not be excluded. Conclusion: Implication deriving from hypothetical coexistence of two different pathological conditions or the possible secondary mitochondrial involvement are discussed.
MEDIATION AS RESOLUTION OF WAQF DISPUTE THROUGH THE INDONESIAN WAQF AGENCY REPRESENTATIVE OF EAST JAVA
Authors: Widiaputri Thirza Adiba 
Published: April 2022

Badan Wakaf Indonesia is the organization that forms by government to advance and develop waqf. As a organization that arranges the waqf road system in Indonesia, Badan Wakaf Indonesia is expected to provide parties who can meet the waqf requirements through non-litigation in advance in accordance with Article 62 of Law Number 41 Year 2004 Regarding Waqf, consensus agreement and alternative dispute resolution becomes an effort first. The subject of the matter that the author takes is the transition from mediation organized by the Badan Wakaf Indonesia and protection over the obstacles in the mediation process. The results of this study are an explanation of mediation in the Badan Wakaf Indonesia Perwakilan Jawa Timur and also its analysis. In addition, it also includes an analysis of negotiations conducted by the Badan Wakaf Indonesia Perwakilan Jawa Timur in the resolution of waqf disputes.

Keyword : Waqf, Badan Wakaf Indonesia, Mediation
Law Enforcement Against Wildlife Poachers is Protected in Bromo Tengger Semeru National Park
Authors: Prasadhana Sando Saputra 
Published: April 2022

Abstract
This Thesis, the authors intend to find out and analyze law enforcement against perpetrators of poaching of protected wildlife in Bromo Tengger Semeru National Park. This research uses empirical juridical research methods, namely legal research by direct approach to the facts in the field. This approach is carried out in order to obtain information relating to the author's research either in the form of concrete data from agencies or simply information about law enforcement by the law enforcement officers who handle it. The results of the study can be concluded that not all perpetrators who commit the crime of hunting wild animals are protected with criminal penalties, but some perpetrators are only given guidance and make a stamped statement but also return the animals to their habitat. This sentence was carried out for reasons of pity and humanity; this certainly did not give a deterrent effect to the culprit, besides the lack of area guard personnel and a lack of public awareness as the main cause of law enforcement against protected wildlife poachers in Bromo Tengger Semeru National Park.
Keywords: Conservation, Law Enforcement, Wildlife Protected Crime Acts.
EVALUASI REGULASI PERMAINAN INTERAKTIF ELEKTRONIK DI INDONESIA (STUDI TERHADAP TRANSAKSI ELEKTRONIK ATAS BENDA VIRTUAL)
Authors: Saleh Hasibuan Anwar 
Published: April 2022

Abstract: Transactions through internet media, especially transactions for goods, are interesting things to do a study, especially if the goods being transacted are intangible goods or also known as virtual objects. The problem in this study is related to the legality of electronic transactions on virtual objects in the regulation of electronic interactive games in Indonesia and the legality of electronic transactions on ideal virtual objects in the regulation of electronic interactive games in Indonesia. This type of research is normative legal research. Judging from its nature, the nature of this research is descriptive analytical which is a study to describe and analyze existing problems and is included in the type of library research. Electronic transactions for virtual objects in the regulation of electronic interactive games in Indonesia, such as Mobile Legends: Bang Bang, Player Unknown's Battlegrounds (PUBG), and Call of Duty, are declared valid if the subjective and objective conditions of the electronic contract are met, namely there is an agreement between the parties. The legality of electronic transactions for virtual objects that are ideal in the regulation of electronic interactive games in Indonesia is that online games that are legal and not illegal to be played and prohibition of any illegal transaction patterns in legal online games, such as gambling simulations (roulette) in the game or other gambling simulations that have an economic advantage for online game owners. Keywords: Electronic Transactions, Virtual Objects, Electronic Interactive Games
THE PROTECTION AND PRESERVATION OF MINANGKABAU TRADITIONAL KNOWLEDGE IN MUATAN LOKAL CURRICULUM OF WEST SUMATERA
Authors: Mayuasti Mayuasti , Prahara Surya 
Published: April 2022

Abstrak: Permasalahan dalam penelitian ini adalah tidak ditemukannya kandungan perlindungan dan pelestarian budaya Minangkabau dalam Kurikulum Muatan Lokal yang dikembangkan oleh Pemerintah Provinsi Sumatera Barat. Sebenarnya kurikulum harus memuat kajian tentang perlindungan dan pelestarian budaya dan pengetahuan tradisional sebagaimana diakui oleh Deklarasi PBB tentang Hak-Hak Masyarakat Adat, Pasal 31. Dengan demikian, tujuan dari penelitian ini adalah untuk membuat model Kurikulum Muatan Lokal yang mewujudkan unsur perlindungan dan pelestarian budaya pada konten pembelajaran. Metode penelitian ini adalah Kualitatif dengan pendekatan Participatory Rural Appraisal (PRA). Instrumen yang digunakan adalah wawancara dan observasi yang melibatkan pemerintah daerah dan pejabat adat. Hasil dari penelitian ini adalah model Kurikulum Muatan Lokal Sumatera Barat yang mengintegrasikan isi perlindungan dan pelestarian budaya dengan pengetahuan dan pemahaman tentang budaya itu sendiri.Kata kunci: Perlindungan, Pelestarian, Pengetahuan Adat Minangkabau, Kurikulum Muatan Lokal.
POST-STROKE MOTOR IMPAIRMENTS: THE POSSIBILITIES OF INNOVATIVE TECHNOLOGIES AND THE RESULTS OF THE OWN RESEARCH
Authors: Kostenko E. V. , Petrova L. V. , Rylsky A. V. 
Published: April 2022

Introduction.The article presents an overview of innovative technologies based on methods sensomotor retraining of the patient using neuromuscular electrical stimulation (NFES) and biofeedback (BFB) as the most promising in the medical rehabilitation (MR) of motor impairment in patients with brain stroke (BS). The results of our own study are also presented.The aim of the study - an assessment of the effectiveness of a comprehensive rehabilitation program with the inclusion of NFES and stabilometric postural control using the BFB method in patients with after-stroke motor disfunction in the chronic ischemic stroke (IS).Material and methods. We examined 87 patients (41 women and 46 men) in the chronic IS, mean age 58.4±6.4 years. The stroke duration was 228.59±31.9 days. The main group included 52 patients who, along with the standard treatment regimen, underwent NFES and BFB-stabilometric training. The comparison group consisted of 35 patients whose rehabilitation complex did not include the above methods.Results and conclusion. Due to comlex rehabilitation with NFES and BFB stabilometric postural training it has been improved the function of walking. The clinical effect was noted 3 weeks after the start of rehabilitation, reaching a maximum by the 5th week. The inclusion of BFB-based methods in the medical rehabilitation leads to earlier motor and social adaptation of the after-stroke patient, restoration of the impairment balance function, which is associated with an increase in neuroplasticity.
Diagnostic Accuracy of Interferon-Gamma Release Assays for Tuberculous Meningitis: A Systematic Review and Meta-Analysis
Authors: Wen An , Leng Er-Ling , Liu Shi-Min , Zhou Yong-Liang , Cao Wen-Feng , Yao Dong-Yuan , Hu Fan 
Published: April 2022

BackgroundIn this study, we evaluated and compared the accuracy of blood and cerebrospinal fluid (CSF) interferon release tests [interferon-gamma release assays (IGRAs)] in the diagnosis of tuberculous meningitis (TBM) by a meta-analysis of the relevant literature.MethodsWe searched for studies published before 2021 in Medline, Embase, the Cochrane database, and Chinese databases. All studies used the QuantiFERON-TB Gold In-Tube and/or T-SPOT.TB method. Blood and/or CSF tests that met the guidelines for the quality assessment of studies with diagnostic accuracy were included. We used the revised diagnostic accuracy study quality assessment to assess the quality of the included studies. Begg’s funnel plots were used to assess publication bias in the meta-analysis of the diagnostic studies, and statistical analyses were performed by using Stata (Version 12) software.ResultsA total of 12 blood and/or CSF IGRA studies were included in this meta-analysis, with 376 patients and 493 controls. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the summary receiver operating characteristic curve (SROC) of the blood IGRAs in the pooled data from 12 studies were 74% (95% CI: 0.65-0.82), 78% (95% CI: 0.68-0.86), 3.38 (95% CI 2.26-5.06), 0.33 (95% CI: 0.23-0.46), 10.25 (95% CI: 5.46-19.25), and 0.83 (95% CI: 0.79-0.86), respectively. For CSF IGRAs, these values for the pooled data from the 10 studies included were 79% (95% CI: 0.71-0.85), 95% (95% CI: 0.88-0.98), 16.30 (95% CI 6.5-40.83), 0.22 (95% CI: 0.16-0.31), 57.93 (95% CI: 22.56-148.78), and 0.91 (95% CI: 0.88-0.93), respectively.ConclusionCSF IGRAs exhibited a better diagnostic accuracy than blood IGRAs in diagnosing TBM.
Association of Light-Intensity Physical Activity With Mortality in the Older Population: A Nationwide Cohort Study
Authors: Kim Juntae , Yang Pil-Sung , Park Byoung-Eun , Kang Tae Soo , Lim Seong-Hoon , Cho Sungsoo , Lee Su-Yeon , Chung Young Hak , Lee Myung-Yong , Kim Dongmin , Joung Boyoung 
Published: April 2022

BackgroundThere is a paucity of information about mortality related to light-intensity physical activity (LPA) in the older population. We examine the associations between physical activity and mortality, focusing on the effect of light-intensity physical activity and the dose-response relationship between physical activity and mortality.MethodsWe analyzed a total of 58,537 participants aged ≥ 65 years (mean age, 73.9 ± 5.8 years; male, 36.0%) in the Korean National Health Insurance Service database between 2009 and 2012. The Date of the end of follow-up was December 31, 2013. Individuals were divided into four categories according to physical activity intensity: totally sedentary (43.3%), LPA only (35.8%), LPA and moderate- to vigorous-intensity physical activity (MVPA) (16.3%), MVPA only (4.5%). Physical activity was quantified using standardized self-reported questionnaires which composed of the duration and frequency of physical activity.ResultsDuring a mean follow-up of 39.6 ± 14.0 months, 5,651 (9.7%) deaths occurred. Compared with totally sedentary individuals, those in the LPA only, LPA and MVPA, and MVPA only groups showed 26% [hazard ratio (HR) 0.74, 95% confidence interval (CI) 0.68–0.82], 27% (HR 0.73, 95% CI 0.63–0.84), and 34% (HR 0.66, 95% CI 0.54–0.79) lower all-cause mortality risk, showing an inverse relationship between physical activity intensity and mortality risk. In contrast, the LPA only, LPA and MVPA, and MVPA only groups represented a stronger inverse association with CV mortality (LPA: HR 0.76, 95% CI 0.62–0.92; LPA with MVPA: HR 0.74, 95% CI 0.55–0.999; MVPA, HR 0.57, 95% CI 0.37–0.87). Among participants performing LPA alone, participants performing less than the recommended dose of physical activity had lower all-cause mortality than those with sedentary activity (1–249 MET-min/week: HR 0.74, 95% CI 0.67–0.82, 250–499 MET-min/week: HR 0.65, 95% CI 0.59–0.72).ConclusionPhysical activity, even low doses of LPA, was associated with reduced mortality risk in the elderly population. This study may motivate sedentary individuals to engage in any physical activity for mortality benefits.
Inhibition of Human Sulfotransferases by Phthalate Monoesters
Authors: Huang Hui , Lan Bei-Di , Zhang Yu-Jing , Fan Xiao-Juan , Hu Min-Cui , Qin Guo-Qiang , Wang Fei-Ge , Wu Yue , Zheng Tao , Liu Jun-Hui 
Published: April 2022

ObjectiveThis study aimed to investigate the inhibition of human important phase II metabolic enzyme sulfotransferases (SULTs) by phthalate monoesters, which are important metabolites of phthalate esters (PAEs).MethodRecombinant SULT-catalyzed metabolism of p-nitrophenol (PNP) was employed as the probe reactions of SULTs to investigate the inhibition of 8 kinds of phthalate monoesters towards SULT isoforms. An in vitro incubation system was utilized for preliminary screening, and 100 μM of phthalate monoesters was used. Inhibition kinetics were carried out to determine the inhibition of SULTs by phthalate monoesters.ResultMultiple phthalate monoesters have been demonstrated to exert strong inhibition potential towards SULT1A1, SULT1B1, and SULT1E1, and no significant inhibition of phthalate monoesters towards SULT1A3 was found. The activity of SULT1A1 was strongly inhibited by mono-hexyl phthalate (MHP), mono-octyl phthalate (MOP), mono-benzyl phthalate (MBZP), and mono-ethylhexyl phthalate (MEHP). Monobutyl phthalate (MBP), MHP, MOP, mono-cyclohexyl phthalate (MCHP), and MEHP significantly inhibited the activity of SULT1B1. MHP, MOP, and MEHP significantly inhibited the activity of SULT1E1. MOP was chosen as the representative phthalate monoester to determine the inhibition kinetic parameters (Ki) towards SULT1B1 and SULT1E1. The inhibition kinetic parameters (Ki) were calculated to be 2.23 μM for MOP-SULT1B1 and 5.54 μM for MOP-SULT1E1. In silico docking method was utilized to understand the inhibition mechanism of SULT1B1 by phthalate monoesters.ConclusionsAll these information will be beneficial for understanding the risk of phthalate monoester exposure from a new perspective.
Radiomic Model for Determining the Value of Elasticity and Grayscale Ultrasound Diagnoses for Predicting BRAFV600E Mutations in Papillary Thyroid Carcinoma
Authors: Wang Yu-guo , Xu Fei-ju , Agyekum Enock Adjei , Xiang Hong , Wang Yuan-dong , Zhang Jin , Sun Hui , Zhang Guo-liang , Bo Xiang-shu , Lv Wen-zhi , Wang Xian , Hu Shu-dong , Qian Xiao-qin 
Published: April 2022

BRAFV600E is the most common mutated gene in thyroid cancer and is most closely related to papillary thyroid carcinoma(PTC). We investigated the value of elasticity and grayscale ultrasonography for predicting BRAFV600E mutations in PTC.Methods138 patients with PTC who underwent preoperative ultrasound between January 2014 and 2021 were retrospectively examined. Patients were divided into BRAFV600E mutation-free group (n=75) and BRAFV600E mutation group (n=63). Patients were randomly divided into training (n=96) and test (n=42) groups. A total of 479 radiomic features were extracted from the grayscale and elasticity ultra-sonograms. Regression analysis was done to select the features that provided the most information. Then, 10-fold cross-validation was used to compare the performance of different classification algorithms. Logistic regression was used to predict BRAFV600E mutations.ResultsEight radiomics features were extracted from the grayscale ultrasonogram, and five radiomics features were extracted from the elasticity ultrasonogram. Three models were developed using these radiomic features. The models were derived from elasticity ultrasound, grayscale ultrasound, and a combination of grayscale and elasticity ultrasound, with areas under the curve (AUC) 0.952 [95% confidence interval (CI), 0.914−0.990], AUC 0.792 [95% CI, 0.703−0.882], and AUC 0.985 [95% CI, 0.965−1.000] in the training dataset, AUC 0.931 [95% CI, 0.841−1.000], AUC 0. 725 [95% CI, 0.569−0.880], and AUC 0.938 [95% CI, 0.851−1.000] in the test dataset, respectively.ConclusionThe radiomic model based on grayscale and elasticity ultrasound had a good predictive value for BRAFV600E gene mutations in patients with PTC.
Predicting Durable Responses to Immune Checkpoint Inhibitors in Non-Small-Cell Lung Cancer Using a Multi-Feature Model
Authors: Wang Lei , Zhang Hongbing , Pan Chaohu , Yi Jian , Cui Xiaoli , Li Na , Wang Jiaqian , Gao Zhibo , Wu Dongfang , Chen Jun , Jiang Jizong , Chu Qian 
Published: April 2022

Due to the complex mechanisms affecting anti-tumor immune response, a single biomarker is insufficient to identify patients who will benefit from immune checkpoint inhibitors (ICIs) treatment. Therefore, a comprehensive predictive model is urgently required to predict the response to ICIs. A total of 162 non-small-cell lung cancer (NSCLC) patients undergoing ICIs treatment from three independent cohorts were enrolled and used as training and test cohorts (training cohort = 69, test cohort1 = 72, test cohort2 = 21). Eight genomic markers were extracted or calculated for each patient. Ten machine learning classifiers, such as the gaussian process classifier, random forest, and support vector machine (SVM), were evaluated. Three genomic biomarkers, namely tumor mutation burden, intratumoral heterogeneity, and loss of heterozygosity in human leukocyte antigen were screened out, and the SVM_poly method was adopted to construct a durable clinical benefit (DCB) prediction model. Compared with a single biomarker, the DCB multi-feature model exhibits better predictive value with the area under the curve values equal to 0.77 and 0.78 for test cohort1 and cohort2, respectively. The patients predicted to have DCB showed improved median progression-free survival (mPFS) and median overall survival (mOS) than those predicted to have non-durable clinical benefit.
Inversed Ratio of CD39/CD73 Expression on γδ T Cells in HIV Versus Healthy Controls Correlates With Immune Activation and Disease Progression
Authors: Kolbe Katharina , Wittner Melanie , Hartjen Philip , Hüfner Anja-Dorothee , Degen Olaf , Ackermann Christin , Cords Leon , Stellbrink Hans-Jürgen , Haag Friedrich , Schulze zur Wiesch Julian 
Published: April 2022

Backgroundγδ T cells are unconventional T cells that have been demonstrated to be crucial for the pathogenesis and potentially for the cure of HIV-1 infection. The ectonucleotidase CD39 is part of the purinergic pathway that regulates immune responses by degradation of pro-inflammatory ATP in concert with CD73. Few studies on the expression of the ectoenzymes CD73 and CD39 on human γδ T cells in HIV have been performed to date.MethodsPBMC of n=86 HIV-1-infected patients were compared to PBMC of n=26 healthy individuals using 16-color flow cytometry determining the surface expression of CD39 and CD73 on Vδ1 and Vδ2 T cells in association with differentiation (CD45RA, CD28, CD27), activation and exhaustion (TIGIT, PD-1, CD38, and HLA-DR), and assessing the intracellular production of pro- and anti-inflammatory cytokines (IL-2, TGF-ß, TNF-α, Granzyme B, IL-10, IFN-γ) afterin vitrostimulation with PMA/ionomycin.ResultsCD39 and CD73 expression on γδ T cells were inversed in HIV infection which correlated with HIV disease progression and immune activation. CD39, but not CD73 expression on γδ T cells of ART-treated patients returned to levels comparable with those of healthy individuals. Only a small subset (&lt;1%) of γδ T cells co-expressed CD39 and CD73 in healthy or HIV-infected individuals. There were significantly more exhausted and terminally differentiated CD39+ Vδ1 T cells regardless of the disease status. Functionally, IL-10 was only detectable in CD39+ γδ T cells afterin vitrostimulation in all groups studied. Viremic HIV-infected patients showed the highest levels of IL-10 production. The highest percentage of IL-10+ cells was found in the small CD39/CD73 co-expressing γδ T-cell population, both in healthy and HIV-infected individuals. Also, CD39+ Vδ2 T cells produced IL-10 more frequently than their CD39+ Vδ1 counterparts in all individuals regardless of the HIV status.ConclusionsOur results point towards a potential immunomodulatory role of CD39+ and CD73+ γδ T cells in the pathogenesis of chronic HIV infection that needs further investigation.
Characterization of Two TNF-Related Subtypes Predicting Infliximab Therapy Responses in Crohn’s Disease
Authors: Ye Chenglin , Zhu Sizhe , Yuan Jingping 
Published: April 2022

BackgroundAnti–tumor necrosis factor (TNF) therapy is widely used to treat Crohn’s disease (CD). Unfortunately, 10%–40% of patients have primary non-response to anti-TNF therapy. TNF family genes play crucial roles in inflammation and immune regulation; however, the effects of TNF family genes on CD remain unclear.MethodsCD expression profiles were downloaded from the Gene Expression Omnibus database. Unsupervised clustering was then used to identify the gene subtypes in CD based on the expressions of TNF family genes. The features of the gene subtypes were characterized using functional enrichment and immune infiltration analyses, and biomarkers of the gene subtypes were identified.ResultsPatients with CD were divided on the basis of unsupervised clustering into two gene subtypes: immune and metabolic. Gene subtype A was significantly correlated with leukocyte migration and cytokine interactions, whereas gene subtype B was associated with metabolic pathways. Whereas 89.5% of the patients in gene subtype B responded to infliximab, only 16.7% of patients in gene subtype A responded. In addition, a combination of interleukin 1 beta (IL1β), interleukin 6 (IL6), and Toll-like receptor 4 (TLR4) can effectively distinguish between gene subtypes A and B.ConclusionComprehensive analyses of the TNF family genes may reveal the underlying pathogenesis of CD. The classification of subtypes may provide new ideas for the personalized treatment of patients with CD.