bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of pacemaker-induced superior vena cava syndrome by direct oral anticoagulant
Authors: Huang Weijun , Chen Yingwen , Liu Ziwei , Huang Yuli , Hu Yunzhao 
Published: August 2022

Abstract
Background
The use of cardiac implantable electronic device have grown substantially over the past two decades, lead related vascular issues are commonly encountered in clinical practice. Superior vena cava (SVC) syndrome due to pacemaker leads is an uncommon complication. Anticoagulation currently remains the mainstay of therapy to restore some degree of patency and relieve swelling. However, there is very limited clinical trials on direct oral anticoagulants (DOACs) .
Case presentation:
We report a case of a 80-year-old man who developed SVC syndrome after transvenous pacemaker implantation with symptoms of obstruction were significantly relieved after four months of DOACs. His symptoms had complete resolved nine months later.
Conclusions
DOACs are effective in the treatment of SVC syndrome after pacemaker implantation, representing an important new approach. It is a very good choice for patients who do not want to undergo interventional therapy.
Operando reconstruction towards CuI nanodots with favorable facets and stable Cu+ state for selective CO2-to-C2H4 conversion
Authors: Xue Wenjie , Liu Hongxia , Yang Ruoou , Liu Youwen , Xia Bao Yu , You Bo 
Published: August 2022

AbstractCu-based electrocatalysts with favorable facets and Cu+can boost CO2reduction to valuable multi-carbon products. However, the inevitable Cu+reduction and phase evolution usually result in poor performance. Herein, we fabricate CuI nanodots with favorable (220) facets and stable Cu+state, accomplished by operando reconstruction of Cu(OH)2under CO2- and I--contained electrolyte for enhanced CO2-to-C2H4conversion. In-situ Raman spectroscopy and thermodynamic potential analysis reveal the preferred formation of CuI which is stabilized by I-; vacuum gas electroresponse experiments and density functional theory (DFT) calculations demonstrate that CO2-related species induce the exposure of (220) of CuI. The resulting electrocatalysts exhibit a high C2H4Faradaic efficiency of 72.4% at a large current density of 800 mA cm-2and robust stability for 12 h in a flow cell. Combined in-situ ATR-SEIRS spectroscopic characterizations and DFT calculations indicate the (220) facets and stable Cu+in CuI synergistically facilitate CO2/*CO adsorption and *CO dimerization.
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy
Authors: Martins-Ferreira Ricardo , Leal Bárbara , Chaves João , Ciudad Laura , Samões Raquel , Silva António Martins da , Costa Paulo Pinho , Ballestar Esteban 
Published: August 2022

Abstract
Background: DNA methylation profiling of circulating cell-free DNA (cfDNA) has rapidly become a promising strategy for biomarker identification and development. The cell-type-specific nature of DNA methylation patterns and the direct relationship between cfDNA and apoptosis can potentially be used non-invasively to predict local alterations. In addition, direct detection of altered DNA methylation patterns performs well as a biomarker. In a previous study, we demonstrated marked DNA methylation alterations in brain tissue from patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) patients. Experimental Design: We performed DNA methylation profiling in cfDNA isolated from serum of MTLE patients and healthy controls using beadchip arrays followed by systematic bioinformatic analysis including deconvolution analysis and integration with DNase accessibility datasets. Results: Differential cfDNA methylation analysis showed overrepresentation of gene ontology terms and transcription factors related to central nervous system function and regulation. Deconvolution analysis of the DNA methylation datasets ruled out the possibility that the observed differences were due to changes in the proportional contribution of cortical neurons in cfDNA. Moreover, we found no overrepresentation of neuron- or glia-specific patterns in the described cfDNA methylation patterns. However, the MTLE-HS cfDNA methylation patterns featured significant overrepresentation of the epileptic DNA methylation alterations previously observed in hippocampus. Conclusions: Our results support the use of cfDNA methylation profiling as a rational approach to seeking non-invasive and reproducible epilepsy biomarkers.
Mannitol for Prevention of Acute Kidney Injury after Liver Transplantation: A Randomized Controlled Trial
Authors: Emara Moataz Maher , Diab Doaa Galal , Yassen Amr Mohamed , Abo-Zeid Maha A 
Published: August 2022

Abstract
Background: Acute kidney injury (AKI) is a common complication after liver transplantation, which is associated with increased morbidity and mortality. Therefore, this study investigated mannitol as an oxygen-free radical scavenger and its role in the prevention of early AKI after a living donor liver transplantation (LDLT).Methods: A total of 84 adult patients who underwent LDLT were randomly assigned to two equal groups: the M group, where patients received 1 g/kg mannitol 20%, or the S group, where patients received an equal volume of saline. The primary outcome was the incidence of early AKI, defined as a 0.3 mg/dl increase in the serum creatinine 48 h postoperatively. Laboratory assessments of the graft and creatinine were recorded until 3 months after transplantation besides the post-reperfusion syndrome and the intraoperative hemodynamic measurements.Results: The AKI incidence was comparable between groups (relative risk ratio of 1.285, 95% CI 0.598–2.759, P = 0.518). Moreover, AKI stages and serum creatinine 3 months after transplantation, P = 0.23 and P = 0.25, respectively. The incidence of the post-reperfusion syndrome was comparable in both groups, 29/39 (74.4%) and 31/41 (75.6%) in M and S groups, respectively, P = 0.897. The intraoperative hemodynamic parameters showed no significant difference between groups using the area under the curve.Conclusion: The 1 g/kg mannitol infusion in the pre-reperfusion period did not reduce the risk of early AKI or post-reperfusion syndrome.Clinical trial registration number: Pan African Clinical Trials Registry (PACTR202203622900599)
Gender Rating &amp; Regional Effect on Insurance Price
Authors: Bereketoğlu Abdullah Burkan 
Published: August 2022

Abstract
Even to this day, region and gender in many countries are believed to be one of the most important parameters to measure the pricing or cost of the health insurance that is going to apply to a person. Here in this study, the goal is to analyze causal inferences and effects of the gender and region by bayesian models built to measure the total and direct effect of gender and region. In the end, beliefs of region and gender are important parameters are discussed, and results from a conclusion are given on the case. The use of the PyMC module embedded in the Python programming language is used as the main modeling method.
Potential Novel Therapeutic Targets in Epilepsy from The View of Intestinal Comorbidities
Authors: Jiang Mi , Li Jia , Song Zhi 
Published: August 2022

Abstract
Background: Epilepsy is a complicated neurological disorder with almost 30% refractory. Recent years, several studies showed that epilepsy is associated with its comorbidities by shared molecular mechanisms. However, the association of epilepsy and digestive comorbidities are still unclear. In this study, we aim to explore the association between inflammatory bowel disease (IBD) and epilepsy, and to find promising therapeutic targets for refractory epilepsy. Methods: Two gene expression profiles (GSE134697 and GSE59071) were selected from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified by GEO2R and the DESeq2 package. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of intersection DEGs and Gene Set Enrichment Analysis (GSEA) were conducted by clusterProfiler package. The protein-protein interactions (PPI) network was established by using STRING and visualized by Cytoscape. Genes in the most significant module identified by MCODE plug-in were considered as candidate hub genes. Validation of hub genes were performed by using the GSE143272 dataset. Results: CXCL8, CXCR4 and ITGAX were identified as the hub genes. Conclusions: CXCL8, CXCR4 and ITGAX were the shared molecular mechanism of epilepsy and IBD, which were potentially novel therapeutic targets in epilepsy.
Thidiazuron‐Induced Tissue Culture Regeneration from Quartered‐Seed Explants of Arachis Paraguariensis
Authors: Aina Olubunmi , Quesenberry Kenneth , Gallo Maria 
Published: August 2022

ABSTRACTArachis paraguariensis Chodat & Hassl. is a potential source of novel genes for the genetic improvement of cultivated peanut (Arachis hypogaea L.) because some of its accessions show high levels of resistance to early leaf spot caused by Cercospora arachidicola Hori. In this study, induction of high frequency shoot regeneration from quartered‐seed explants was accomplished for six plant introductions of A. paraguariensis under continuous light on Murashige and Skoog (MS) medium containing 4.4 mg L−1 thidiazuron (TDZ) in combination with 2.2 mg L−1 6‐γ‐γ‐(dimethylallylamino)‐purine (2ip). Recovery of a moderately high number of plantlets per quarter seed cultured was also achieved on medium containing 4.4 mg L−1 thidiazuron in combination with 1.1 to 4.4 mg L−1 6‐benzylaminopurine (BAP) with bud formation occurring as early as 1 wk after culture initiation. There were no differences in seed production or in early leaf spot incidence between plants of two genotypes of A. paraguariensis derived from seeds vs. in vitro tissue culture derived plants; however, cultivated peanut cv. Florunner had a higher incidence of early leaf spot.
Comparative evaluation of therapy results in mild acne
Authors: Khismatulina I. M. , Faizullina E. V. , Gusarova E. S. , Nabieva R. R. 
Published: August 2022

Introduction. Mild acne is the most underestimated form of the disease.The aim of the study was to compare the results of external combination therapy with 15% azelaic acid gel + 1% clindamycin gel and benzoyl peroxide + clindamycin for mild papulopustular acne.Material and methods. An open comparative prospective observational study in parallel groups (12 weeks) included 96 people, 65 patients with mild papulo-pustular acne and a control group of 30 healthy individuals. Group I received 15% azelaic acid gel +1% clindamycin gel, group II – benzoyl peroxide gel + clindamycin. The number of acne elements, morphofunctional indicators of the facial skin, side effects were recorded.Results. As a result of treatment, the indicators of sebumetry significantly decreased: in group I in the T-zone 47.5 ± 11.3 units (p = 0.043) and in the U-zone 57.5 ± 6.3 units (p = 0.037), and in group II in the T-zone 37.1 ± 5.8 units (p = 0.015) and in the U-zone 48.7 ± 5.6 units (p = 0.027). The pore sizes decreased significantly: in group I in the T-zone 0.052 ± 0.010 mm (p = 0.046) and in the U-zone 0.054 ± 0.009 mm (p = 0.049), and in group II in the T-zone 0.039 ± 0.011 mm (p = 0.064) and in the U-zone 0.047 ± 0.013 mm (p = 0.041). In patients in group I, pigmentation indicators in the T-zone of 17.0 ± 2.8 units (p < 0.001) and the U-zone of 17.0 ± 2.8 units (p = 0.048) were normalized. In patients in both groups, there was a significant (p >< 0.05) decrease in the number of papulopustules.>˂ 0.001) and the U-zone of 17.0 ± 2.8 units (p = 0.048) were normalized. In patients in both groups, there was a significant (p ˂ 0.05) decrease in the number of papulopustules.Conclusion. When comparing the results of therapy with 15% azelaic acid gel + 1% clindamycin gel and benzoyl peroxide + adapalene for mild papulopustular acne, comparable efficacy and safety were revealed.
Internal Locus of Control, Self-Efficacy, Self-Esteem, dan Prokrastinasi Akademik Mahasiswa PAI FITK UIN Walisongo Semarang
Authors: Asiyah Nur , Syukur Fatah 
Published: August 2022

Penelitian ini bertujuan manganalisis tentang: Internal locus of control, self-efficacy, self-esteem dan prokrastinasi akademik mahasiswa PAI FITK UIN Walisongo Semarang. Dalam penelitian ini, analisis data menggunakan analisis kuantitatif deskriptif untuk menganalisis internal locus of control, self-efficacy, self-esteem dan prokrastinasi akademik mahasiswa PAI. sedangkan untuk menganalisis pengaruh internal locus of control, self-efficacy, self-esteem terhadap prokrastinasi akademik mahasiswa PAI FITK UIN Walisongo Semarang digunakan analisis regresi. Dari hasil analisis penelitian ini didapatkan beberapa temuan: pertama, ada pengaruh negatif yang tidak signifikan antara internal locus of control dengan prokrastinasi akademik mahasiswa PAI FITK UIN Walisongo Semarang. Persamaan garis regresinya adalah Y`=73.138-0,720X, nilai sig 0,1020,05. Besarnya pengaruh internal locus of control terhadap prokrastinasi akademik 0,328, dengan kontribusi sebesar 10,7%. Kedua, Ada pengaruh negatif yang signifikan self-efficacy terhadap prokrastinasi akademik mahasiswa PAI FITK UIN Walisongo Semarang, dengan persamaan regresi Y`=75.179-0,552X, dan nilai sig 0,0070,05. Besarnya pengaruh sebesar 0,328. dan kontribusinya sebesar 10,8%. Ketiga, ada pengaruh negatif yang signifikan self-esteem terhadap prokrastinasi akademik mahasiswa PAI FITK UIN Walisongo Semarang dengan nilai sig 0,0360,05, dan persamaan regresinya Y`=82,794-0,490X, dengan besar pengaruh 0,414, dengan kontribusi sebesar 17,1%. Keempat, ada pengaruh negatif dan signifikan antara internal locus of control, self-efficacy, self-esteem secara bersama-sama dengan prokrastinasi akademik mahasiswa PAI FITK UIN Walisongo Semarang, dengan persamaan regresi Y`=119,552-0,649X1-0,423X2-0,273X3 dan nilai sig 0,0070,05. Pengaruhnya sebesar 0,641, dengan kontribusi sebesar 41%. Sisanya sebesar 59% ditentukan faktor lain.
Analysis of the optical properties of ZnO thin films deposited on a glass substrate by the So-gel method
Authors: Amananti Wilda , Ardiyanto Riky , Sutanto Heri , Nurhasanah Iis , Tivani Inur 
Published: August 2022

Zinc oxide (ZnO) has attracted the attention of researchers as a photocatalyst material, because ZnO has a wide direct band gap (3.37 eV) and is a semiconductor material with a large excitation binding energy (60 meV). ZnO is a photocatalyst that has many advantages, namely cheap, non-toxic, and theoretically very active under UV irradiation. The most interesting thing about ZnO semiconductor compared to other semiconductors is that ZnO can absorb most of the solar spectrum. However, there is a weakness of the ZnO semiconductor, namely the very fast recombination of charge carriers and the ZnO semiconductor has a low efficiency in the visible region which causes the ZnO semiconductor to have a wide band gap. that is the weakness of ZnO. it is necessary to choose the right method to overcome this deficiency of ZnO. one way that can be done is to increase the photocatalytic ability of zinc oxide, it is necessary to develop it in the manufacture of thin films. The method used in the manufacture of Thin Film is using the sol-gel spray coating method. the first stage is through the manufacture of ZnO precursors by dissolving zinc acetate dehydrate with isopropanol solvent through stirring. then the second stage by adding Monoethanolamine. This stirring lasted for 30 minutes at a temperature of 70°C, the precursor concentration was prepared with three different concentrations which included concentrations of 0.1, 0.3, and 0.5 M. ZnO precursor deposited on the substrate glass is blown at 400 °C. Optical properties are carried out by recording the transmittance and absorbance which are affected by increasing concentrations. The optical transmission spectra show that the transmission increases with decreasing concentration and the maximum transmission in the visible region is about 90% for ZnO thin films prepared with 0.1 M. The optical band gap value produced by the thin film of 0.1 M precursor concentration resulted in an energy band gap of 3.11 eV; thin films of 0.3 M precursor concentration produced an energy band gap of 3.07 eV; and thin film of 0.5M precursor concentration produced an energy band gap of 3.06 eV.©2022 JNSMR UIN Walisongo. All rights reserved.
Simultaneous high p-nitrophenol concentration and nitrogen removal by two-stage membrane biofilm reactor
Authors: Tong Jiayi , Cui Li , Wang Danqi , Wang Xin , Liu Zhaokun 
Published: August 2022

Abstract
P-nitrophenol (PNP) is highly toxic and difficult to degrade, causing great harm to the ecological environment and human health. A two-stage bench-scale membrane biofilm reactor (MBfR) was constructed to treat wastewater containing high concentration of PNP and the generated nitrogen without external organic carbon sources. The two reactors were supplied with oxygen and methane, respectively. O2-MBfR was used for the degradation of PNP and the improvement of wastewater biodegradability. CH4-MBfR was used for the total nitrogen (TN) removal treatment from O2-MBfR effluent. In this experiment, the performance of the two-stage MBfR process was evaluated and optimized by adjusting operational parameters (aeration pressure, HRT, and pH). Under the optimal operation parameters, the removal efficiencies of PNP (100 mg/L) and TN attained 89.70% and 69.24%, respectively, and the removal loads were 0.930 g·m−2·d−1 and 241.42 mg·m−2·d−1, respectively. The reactor was able to accommodate the concentrations of PNP up to 200–400 mg/L, and the reactor reached maximum efficiency throughout the process when the concentration of PNP in the wastewater was 250 mg/L. The removal rates of PNP and TN reached 95.0% and 69.48%, respectively, and the removal loads were 2.37 g·m−2·d−1 and 96.22 mg·m−2·d−1, respectively. This research provides a better solution for multi-MBfR to treat toxic industrial wastewater containing phenol, nitrophenol, and further TN removal, which would not release any air pollutants into the atmosphere.
Adipose-Renal Axis in Diabetic Nephropathy
Authors: Yang Ming , Song Panai , Zhao Li , Wang Xi 
Published: August 2022

Abstract:
Long-term diabetes can lead to renal injury known as diabetic nephropathy (DN), which is a major cause of end-stage renal disease (ESRD). However, its pathogenesis has not been well explained. Adipose tissue is recognized as an important energy storage device for the body. Interestingly, many studies have shown that adipose tissue can also act as an endocrine organ by secreting a variety of adipokines to maintain homeostasis. Here, we summarize some of the adipokines that have been identified thus far to, more specifically, to emphasize their role in DN progression and propose that the “adipose-renal axis” may be a potential target for the treatment of DN.
Pulmonary Fibrosis; Risk Factors and Molecular Triggers, Insight for Neo
Therapeutic Approach
Authors: Marzoog Basheer Abdullah 
Published: August 2022

Abstract:
Overactivation of the local pulmonary fibroblast induces hyperproduction of the extracellular matrix. A myriad of pathomorphological changes occur during lung fibrosis, including interalveolar space (interstitial) deposition due to proliferation and differentiation of resident fibroblasts, recruitment of circulating stem cells and epithelial–mesenchymal transition, highly reactive and hyperplastic alveolar epithelium. Currently, many endogenous and exogenous factors are believed to be associated with lung fibrosis development. However, pathogenetic treatment remains in the womb of development. Exploring the underlying pathophysiology is crucial for successful development of pathogenetic treatment. Several molecules termed chemokines and cytokines have been found to induce lung fibrosis, such as IL-6, IL-1β, PDGFRα, TNF-α, GM-CSF, and IL-13. However, many others, such as IL-8, RANTES, IP-10, and MIG or lymphotactin, have an antifibrosis effect. However, the pathogenesis is multifactorial and involves dysregulation of the immune system, impaired cell-cell adhesion regulation mechanisms, and loss of DNA repair. The paper aimed to thoroughly addresses the potential risk factors and molecular triggers of lung fibrosis.
Dosimetric Comparison of Different Radionuclides Used in Metastatic
Bone Disease Treatment
Authors: Kökkülünk Handan Tanyildizi 
Published: August 2022

Introduction:
This study aimed to determine the critical organ doses in 223Ra, 89Sr, 153Sm, and 32P treatments via dosimetry using the phantoms.

Material and Methods:
The OpenDose was used to calculate S values (mGy MBq-1s-1) for bone surface, red bone marrow, urinary bladder wall, testes, ovaries, uterus, and kidneys using male (ICRP110AM) and female (ICRP110AF) phantoms. The cortical thoracic spine was modeled as me-tastasis. Moreover, the absorbed doses were computed via MIRD formalism according to the activi-ties of 3.3, 148, 2220, and 370 MBq for ICRP110AM and 4.015, 148, 2701, and 370 MBq for ICRP110AF in 223Ra, 89Sr, 153Sm, and 32P treatments, respectively.

Results:
Whilst the maximum bone surface doses were found as 1.22E+02 and 8.51E+01 mGy at 32P treatment, the minimum bone surface doses were calculated as 8.42E-02 and 8.26E-02 mGy at 223Ra. In terms of the comparison of red bone marrow, urinary bladder wall, and kidney doses, 153Sm and 89Sr treatments showed maximum doses of 2.45E-03, 1.50E-03, 3.23E-07, 5.45E-06, 1.20E-01, 1.49E-01 mGy and the minimum doses with 3.46E-05, 1.99E-05, 6.33E-09, 8.77E-09, 1.19E-04, 1.15E-04 mGy, respectively. The maximum testes and ovaries-uterus doses were found as 6.17E-08, 7.40E-06, 3.46E-07 mGy in 153Sm treatment, and minimum testes and ovaries doses as 1.70E-09, 1.34E-07 mGy in 223Ra. The minimum uterus dose with 7.03E-09 mGy was determined in 89Sr treat-ment.

Conclusion:
It is observed that 223Ra produces low critical organ doses in the treatment of painful bone metastasis. Among the beta-emitting radionuclides, 89Sr stands out by showing optimal dosi-metric results.
Overview of COVID-19 Pandemic: Its Management and Prevention in
Light of the Indian Traditional Medicine System
Authors: Saxena Gauri , Singh Lav , Singh Arpit , yadav Divyanshu , Chhavi Apurv , Srivastava Ravi Prakash , Pandey Shivaraman , Dixit Pooja , Ramakant  , Verma Praveen Chandra 
Published: August 2022

Abstract:
With the global death toll nearing 3.3 million, India being amongst the top 4 countries,
the condition is more than fearsome. World Health Organization (WHO) recommends one doctor
per 1000 population ratio, but India lags it by one doctor to 1456 people, which sets a lot of pressure
on the healthcare system. Traditional remedies are becoming increasingly popular in India as a result
of the lack of a proper medical system. Due to the rich diversity of medicinal herbs and drugs,
India has been managing health issues with its 5000 years old medication system. Amidst all this,
the traditional medicine system has given relief to plenty of diseases and remains the primary defence
system against COVID-19. Therefore, COVID-19 is also managed by its different medicinal
systems, which are collectively known as the AYUSH regime. It had been a recognized system to
tackle diseases in the past. In this mini-review, we performed a deep study of the Indian traditional
medicine system in managing the COVID-19 situation.