bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comorbid Parental Psychopathology Interactions: Associations with Emerging Adult Psychological Problems
Authors: Fowler Camille , Stanhope Lydia , McKinney Cliff 
Published: October 2022

Abstract

Research has investigated the effects of parental psychopathology in young children, but few studies have examined the role that comorbid parental psychopathology within and between parents has on emerging adults. These effects can differ depending on the gender of the emerging adult and parent. The current study examined how maternal and paternal psychopathology predicted emerging adult psychopathology from the emerging adults’ perspectives by gender. To increase parsimony, the study focused on depressive, anxious, and antisocial problems. Results demonstrated that parental psychopathology was a strong predictor of the same psychopathology in emerging adults. Women and men reported moderate depressive problems when indicating high scores for both maternal antisocial and paternal anxiety problems, whereas being high in one parental problem and low in the other resulted in higher depressive problems. The findings indicated that comorbid psychopathology within and between parents may increase psychopathology in emerging adults, but some combinations may moderate effects.
Predictors of herbal medicine use among cancer patients
Authors: Aboufaras Mohamed , Selmaoui Karima , Raja Najib , lakhdissi asmaa , ouzennou nadia 
Published: October 2022

Abstract

Purpose The aim of this study is to assess the prevalence, the determinants and the predictors of this use. Methods At the regional oncology center of Beni Mellal, we conducted a descriptive and analytical cross-sectional study with 530 adult cancer patients chosen by quota sampling. A 54-item questionnaire was used to perform the face-to-face survey. The theory of planned behavior (TPB) and a CAM healthcare model were used to create this instrument. Using SPSS software, we performed bivariate and multivariate statistical analyses as well as logistic regression. Results The prevalence of traditional herbal medicine use was 36.6%. Several variables of the conceptual model were associated with the use of herbal medicine (gender, attitude and belief towards T&CM, financial resources, clinical characteristics of patients) (p < 0.05). Predictors of traditional herbal medicine use were female gender (OR = 4.687; p < 0.000), social impact of cancer (OR = 2.314; p < 0.05), emotional impact of cancer (OR = 2.314; p < 0. 05), expected benefits of TM/CAM use (OR = 3.453; p < 0.000), perceived scientific barriers (OR = 0.580; p < 0.000), perceived socioeconomic barriers (OR = 0.657; p < 0.005), and the use and social norms of relatives (OR = 3.238; p < 0). Conclusion Because of the high prevalence of herbal medicine, health care providers should focus on specialized and multidisciplinary therapeutic education that focuses on the psychosocial factors and representations that underpin this use.
Experimental and Finite Element Analysis of Plastic Domain Evolution of Rough Surfaces during Contact
Authors: Huang Jiaxin , Zhang Xiaoyue , Sun Chen , Chen Jubing 
Published: October 2022

Abstract
The processing method has an effect on the morphology and yield strength of the rough surface. In this paper, experiments and finite element methods are used to analyze the contact behavior of asperities on the rough surface. And the effects of the distribution, height, surface noise, and yield strength of the asperities on the rough surface on the plastic expansion of the asperities are discussed. For the rough surface of the aluminum alloy machined by the three processing methods, the plastic evolution of the surface asperities is directly observed in the experiment. The results show that when the surface roughness is lower, the plastic growth of various asperities on the surface is more uniform. We consider that the morphology of the asperities consists of the periodic morphology and the noise of this morphology. The plastic deformations of rough surfaces with different morphologies are analyzed by finite element method. The results show that the higher the frequency of the asperity distribution, the smaller the plastic deformation under the same load. And the plastic deformation of asperities increases with height. In addition, the mean value of the noise has a limited effect on the plastic change of the rough surface. However, when the noise variance gradually increases, the plastic area of the asperities shows a slow upward trend.
Comparison of Obstetric Emergency Clinical Readiness: A Cross-Sectional Analysis of Hospitals in Amhara, Ethiopia
Authors: Dougherty Kylie , Gobezayehu Abebe Gebremariam , Lijalem Mulusew , Endalamaw Lamesgin Alamineh , Cranmer John N. 
Published: October 2022

Abstract
Background
Measuring facility readiness to manage basic obstetric emergencies is a critical step toward reducing persistently elevated maternal mortality ratios (MMR). Currently, the Signal Functions (SF) is the gold standard for measuring facility readiness globally and endorsed by the WHO. The presence of tracer items classifies facilities’ readiness to manage basic emergencies. However, research suggests the signal functions may be an incomplete indicator. The Clinical Cascades (CC) have emerged as a clinically-oriented alternative to measuring readiness. The purpose of this study is to determine Amhara's clinical readiness and quantify the relationship between SF and cascade estimates of readiness.
Methods
Data were collected in May 2021via Open Data Kit (ODK) and KoBo Toolbox. We surveyed 20 hospitals across three levels of the health system. Commodities were used to create measures of SF-readiness (e.g., % tracers) and cascade-readiness. We calculated differences in SF and cascade estimates and calculated readiness loss across five emergencies and 3 stages of care in the cascades.
Results
The overall Signal Function estimate for all 6 obstetric emergencies was 17.5% greater than the estimates using the cascades. Consistent with global patterns, hospitals were more prepared to provide medical management (70.0% ready) compared to manual procedures (56.7% ready). The SF overestimate was greater for manual procedures (26.7% overall for retained placenta and incomplete abortion) and less for medical treatments (8.3%). Hospitals were least prepared to manage retained placentas (30.0% of facilities were ready at treatment and 0.0% were ready at monitor and modify) and most able to manage hypertensive emergencies (85.0% of facilities were ready at the treatment stage). When including protocols in the analysis, no facilities were ready to monitor and modify the initial therapy when clinically indicated for 3 common emergencies—sepsis, post-partum hemorrhage and retained placentas.
Conclusions
We identified a significant discrepancy between SF and CC readiness classifications. Those facilities that fall within this discrepancy are unprepared to manage common obstetric emergencies, but regional health planners are unable to identify the need. Future research should explore the possibility of modifying the SF or replacing it with a new readiness measurement.
Simultaneous detection of dopamine and ascorbic acid by a thread-based microfluidic device and multiple pulse amperometry
Authors: Santos Vanessa W. dos , Martins Gustavo , Gogola Jeferson L. , Kalinke Cristiane , Agustini Deonir , Bergamini Márcio F. , Marcolino-Junior Luiz H. 
Published: October 2022

Abstract
In this work, the simultaneous determination of ascorbic acid (AA) and dopamine (DA) was proposed using a simple and inexpensive microfluidic device. Microfluidic devices are totally suitable to couple with electrochemical detectors such as screen-printed electrodes (SPE) and offer many advantages: portability, high sample throughput and low reagent consumption. Here, a 3D-printed microfluidic device (µTED) was developed using textile threads as microfluidic channels and an unmodified SPE as amperometric detector. By using the multiple pulse amperometry (MPA), two potential values (0.65 V and − 0.10 V) were chosen. The current signals generated in the reduction of dopamine o-quinone were used to calculate a correction factor for the ascorbic acid oxidation signals, allowing the simultaneous quantification. The proposed microfluidic device provided a stable flowrate of carrier solution and low consumption of samples and reagents (volume of injection of 2.0 µL). Using the best set of experimental conditions, a linear dynamic range (LDR) between 50 and 900 µmol L− 1 for DA and AA were achieved. Sensitivities of 2.24 µA L µmol− 1 and 5.09 µA L µmol− 1 as well as limits of detection (LOD) of 2.60 µmol L− 1 and 1.54 µmol L− 1 were calculated for AA and DA, respectively. The proposed method was successfully applied for simultaneous determination of AA and DA in commercial blood serum sample spiked at three concentration levels. In addition, MPA showed to be a very simple way to perform simultaneous determination of AA and DA without the need of previous separations or the use of chemically modified electrodes.
Performance of a novel Convolutional Neural Network with the incorporation of automatic segmentation of peritumoral region in shear-wave elastography for predicting breast cancer
Authors: Xie Li , Liu Zhen , Pei Chong , Liu Xiao , Cui Ya-yun , Wang Yunqiu , Yang Lin , He Nian-an , Hu Lei 
Published: October 2022

Abstract
Objective: Peritumoral stiffness of lesions measured by shear-wave elastography (SWE) can improve the diagnostic specificity of the conventional ultrasound(US) in breast cancer. Our aim was to develop dual-modal CNN models based on combining US images and SWE of peritumoral region to improve prediction of breast cancer.
Materials and Methods: We retrospectively collected US images and SWE data of 1271 BI-RADS-4 breast lesions from 1116 female patients (mean age ± standard deviation, 45.40 ± 9.65 years). The lesions were divided into three subgroups based on the maximum diameter (MD): ≤15 mm; >15 mm and ≤25 mm; >25 mm. We recorded lesion stiffness (SWV1) and 5-point average stiffness of the peritumoral tissue (SWV5). Based on the segmentation of different widths of peritumoral tissue (0.5 mm, 1.0 mm, 1.5 mm, 2.0 mm) and internal SWE image of the lesions, CNN models were built using PP-LiteSeg and EfficientNet-B0 architecture. All single-parameter CNN models, dual-modal CNN models, and quantitative SWE parameters inthe training cohort (971 lesions) and the validation cohort (300 lesions) were assessed by receiver operating characteristic (ROC) curve.
Results: The dual-modal CNN models based on the combination of US and SWE segmentation images had better diagnostic performance than the quantitative SWE parameters, US CNN model, and SWE CNN models in predicting breast cancer (P < 0.001 for all). The US + 1.0 mm SWE model achieved the highest area under the ROC curve (AUC) in the subgroup of lesions with MD ≤15 mm in both the training (0.94) and the validation cohorts (0.91). In the subgroups with MD between 15 and 25 mm and above 25 mm, the US + 2.0 mm SWE model achieved the highest AUCs in both the training cohort (0.96 and 0.95, respectively) and the validation cohort (0.93 and 0.91, respectively).
Conclusion: The dual-modal CNN models based on the combination of US images and peritumoral region SWE images allow accurate prediction of breast cancer.
Docking, ADME toxicity analysis of Alprazolam derivatives as potent anxiolytic drug
Authors: Praveen Mallari , Paramanik Vijay 
Published: October 2022

Abstract
GABAergic, Gamma Amino Butyric Acid A (GABAA) receptors are permeable to the chloride ion gated channel, on hyperexcitability alters the ions gradients and leads to anxiety-related diseases. The study aims to elucidate the potent inhibitory ligands of alprazolam and their analogues, those retrieved from the PubChem database as ligands against the GABAA receptor as a target to reduce the daily dose administration. In-silico methods like molecular docking were performed using docking tool, Autodock and Autodock vina version 4.2, Absorption Digestion Metabolism Excretion toxicity through Swiss ADME and OSIRIS online tools to find potent lead ligand and predicting drug-likeness. Molecular docking showed that three compounds A3, A8, and A9 had significant binding affinities (-8.0 to -8.2 kcal/mol) to the target. The ADME toxicity study showed three ligands (PubChem ID: 1032832, 12632256, and 12632257) with good binding affinity, obeyed Lipinski’s rule of five. A8 chemical compound can cross the blood-brain barrier out of three ligands, A3 and A9 ligands remained in the gastrointestinal region, which is represented in the BOILED-Egg model. The study revealed one potent antagonist of GABAA receptors, namely 8-chloro-1,4-dimethyl-6-phenyl-4H- [1,2,4] triazolo [4,3-a] [1,4] benzodiazepine, these can be further exploited for upon molecular dynamics study followed by wet-lab studies perhaps used for the therapeutics as an anxiolytic drug.
Study on the Cognitive Characteristics Induced by Changes in the Intensity, Frequency, and Duration of Vibratory Stimuli
Authors: Choi Mi-Hyun , Kim Kyu-Beom , Kim Ye-Jin , Kim Ji-Su , Kim Hyung-Sik , Chung Soon-Cheol 
Published: October 2022

Abstract
The purpose of this study is to analyze the cognitive characteristics that can be induced through vibration stimuli of two intensities, three frequencies, and five presentation periods. The experiment was conducted on 20 right-handed adult males and a subjective evaluation was performed using a questionnaire. Regression analysis was performed to observe the parameters affecting cognitive characteristics according to changes in intensity, frequency, and stimulation duration. The regression analysis results showed that the cognitive characteristics affected by changes in intensity, frequency, and stimulation duration were 'heavy', 'bold’, 'thick', and 'light'. The cognitive characteristics affected by two-variable combinations were 'deep', 'clear', ‘vibrating’, 'dense', 'numb', 'blunt', 'shallow', 'fuzzy', and 'soft'. Cognitive characteristics affected by one of intensity, frequency, and stimulation duration were 'fast', 'pungent', ' skinny', 'thin', 'slow', 'ticklish', 'tingling', 'prickling', ‘tap', and 'rugged'. In this study, by observing the cognitive characteristics that can be induced through a combination of intensity, frequency, and stimulation duration, we confirmed that, in addition to intensity and frequency, the stimulation duration is an important factor that influences the induction of various cognitive characteristics. The results presented in the study can be used to enhance the utility of a hepatic surface for extended reality applications.
Intermittent Control in Human Balancing on an Unstable and Unrestrained Platform
Authors: Rao Aishwarya , Palanthandalam-Madapusi Harish 
Published: October 2022

Abstract
The presence of an intermittent control strategy in human quiet standing and various balancing tasks is established in the literature. In intermittent control, the variables of interest are monitored continuously but corrective action is only taken intermittently when the variables exceed certain threshold criteria. It is however unclear whether an intermittent control strategy is employed in other balancing tasks such as standing (and balancing) on an unrestrained, unstable platform. In this paper, we study a simple, unrestrained anterior-posterior rocker balancing task using both experimental investigation with human subjects and numerical simulations, to evaluate the presence of an intermittent strategy. For experimental data, we conducted a pilot study with 5 human subjects undertaking both a quiet standing task and a rocker balancing task. For numerical simulations, we employ a Rolling Disk coupled with an Inverted Pendulum (RDIP) model with continuous and intermittent control representing the rocker balancing task and a Simple Inverted Pendulum (SIP) model to represent the quiet standing task. The data and analysis from the experimental study and numerical simulations provide evidence for the presence of an intermittent control strategy in rocker balancing with reduced intermittency and higher postural fluctuations compared to quiet standing.
Plant traits and soil properties involved in nutrient and carbon exchange predict arbuscular mycorrhizal fungal communities under nature ambient precipitation gradients
Authors: Zhang Shihu , Ma Xiaoyu , Ma Qun , Wang Yidi , Yang Xuechun , Yang Zhengying , Wang Jingyuan , Ma Miaojun , Zheng Zhi 
Published: October 2022

Abstract
Aims
Despite several studies demonstrating that plant traits determine plant community response to precipitation changes and that precipitation indirectly affects arbuscular mycorhizal (AM) fungal communities by changes in plant community attributes. Yet the impacts of plant traits on AM fungal communities are still unknown under precipitation change.
Methods
We selected three sites extremely ideal to examine the effects of plant community functional traits and soil properties on AM fungal communities due to similar plant species and precipitation differences in an alpine meadow of Tibetan Plateau.
Results
We observed that high precipitation markedly enhanced AM fungal diversities, plant community functional diversities and soil nutrients. Total soil nitrogen and soil available phosphorus predicted variation in AM fungal diversities, while AM fungal biomass was predicted by plant community-weighed means of nitrogen and phosphorus ratio (CWM-N:P). Members of Glomus preferred to inhabit in the sites with low precipitation. A distance-based redundancy analysis (db-RDA) demonstrated that AM fungal community structure was predicted by CWM-N:P, plant community-weighed means of photosynthetic rate (CWM-Pn), total soil carbon and plant community functional dispersion (FDis).
Conclusions
We conclude that plant traits and soil properties, which are involved in nutrient-carbon (C) exchange in AM fungal symbionts, shape AM fungal communities under ambient precipitation gradients. Our finding provided a novel insight into AM fungal community assembly from the perspective of nutrient-carbon exchange.
Asthma or eosinophilic granulomatosis with polyangiitis: a case-based review
Authors: Wang Pu , Liu Ying , Shao MeiQi , Chen Da 
Published: October 2022

Abstract
Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a small-vessel necrotizing vasculitis. Its most common clinical manifestations are asthma; ear, nose, and throat involvement; and lung involvement. As EGPA has similar features to asthma, most patients with this disease seek medical treatment for the first time with wheezing symptoms and, thus, may be regarded as having asthma.
Case presentation: This report discusses an EGPA case regarded as recurrent asthma for 3 years. The patient underwent thoracic computed tomography (CT) 6 times in recent years, which recorded dynamic changes in an EGPA patient’s lungs for the first time. We initiated treatment with methylprednisolone and amethopterin. The patient’s symptoms rapidly improved, and some abnormal imaging manifestations on chest CT disappeared one month after the treatment.
Conclusions: Consequently, early diagnosis and treatment are needed because the progression of the disease may be prohibited, and imaging manifestations on chest CT of EGPA may be reversible. Furthermore, to diagnose patients with asthma more reliably and precisely, we discuss the differential diagnosis between EGPA and asthma. Thirdly, imaging manifestations on chest CT could be regarded as an evaluation index to evaluate the therapeutic effect in patients with EGPA. Finally, low-dose CS can alleviate the symptoms of EGPA.
Echocardiographic Assessment of Patients with Glycogen Storage Disease in a Single Center
Authors: Seol Jae Hee , Jung Se Yong , Koh Hong , Won Jung Jo , Kang Yun Koo 
Published: October 2022

Abstract
Purpose
Glycogen storage disease (GSD) is a hereditary metabolic disorder caused by enzyme deficiency resulting in glycogen accumulation in the liver, muscle, heart, or kidney. GSD types II, III, IV, and IX are associated with cardiac involvement. However, cardiac manifestation of other GSD types is unclear. This study aimed to describe whether energy deprivation and the toxic effects of accumulated glycogen affect the heart of patients with GSD.
Methods
We evaluated LV wall mass, LV systolic and diastolic function and myocardial strain in 64 patients with GSD type I, III, VI and IX who visited Wonju Severance Hospital in 2021, by conventional echocardiography and two-dimensional speckle-tracking echocardiography (2D STE). Among the GSD patients, the echocardiographic parameters of 55 pediatrics were converted into z-scores and analyzed.
Results
Of the patients, 43(62.3%), 7(11.3%) and 12(19.4%) were diagnosed with GSD type 1, type 3 and type 9, respectively. The median age was 9 years (range, 1–36years), 55 children under 18 years old and 7 adults over 18 years old. Multiple linear regression analysis showed that BMI z-score (p = 0.022) and CK (p = 0.020) predicted increased LV mass z-score, regardless of GSD type. There was no difference in the diastolic and systolic functions according to myocardial thickness, but 2D STE shows a negative correlation with LV mass (r=-0.28, p = 0.041).
Conclusion
Given that GSD patients tend to be overweight. As well as laboratory tests and abdomen ultrasounds of the liver and muscles in patients with GSD are needed, but it is also thought that serial heart evaluation with echocardiography is required.
Intraoocyte cAMP elevation induces Metaphase-I arrest in rat oocytes
Authors: Sharma Alka , Dubey Pawan K. , Tripathi Anima 
Published: October 2022

Abstract
Meiotic cell cycle progression from metaphase-I (M-I) to metaphase-II (M-II) is crucial since oocyte prepares to release first polar body (PB-I) and get converted into mature female gamete. Any disturbance or abnormality during this period could affect formation and extrusion of PB-I and thereby oocyte quality after ovulation. The adenosine 3’-5’-cyclic monophosphate (cAMP) is one of the major signal molecules that regulate the meiotic cell cycle in mammalian oocytes. However, its role during spontaneous exit from metaphase-I (M-I) remains obscure. Therefore, we aimed to find out whether the cell permeable analogue of cAMP that is dibutyryl cAMP could inhibit spontaneous exit from M-I in rat oocytes cultured in vitro. Female rates were exposed to 20 IU pregnant mare’s serum gonadotrophin (PMSG) for 48 hr followed by 20 IU hCG for 10 hr and then cumulus oocyte complexes (COCs) were collected from ovary by puncturing follicles with 26 gauze needles in pre-warmed M-199 culture media. The COCs were cultured in a fresh medium containing various concentrations of db-cAMP (0.0, 0.125, 0.25, 0.50 and 1.0 mM) for 5 hrs in vitro. Our data suggest that db-cAMP prevented oocytes from undergoing spontaneous meiotic resumption from M-I stage in a concentration-dependent manner. The 1.0 mM db-cAMP was sufficient to maintain cell cycle arrest at M-I stage during in vitro culturesuggest that 1.0 mM db-cAMP could be used to prevent spontaneous resumption as well as oocyte aging during in vitrohandling of oocyte in various assisted reproductive technology (ART) programs.