bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Alterations to the Metabolic Connectivity of the Cortical and Subcortical Regions in Rat Brain During Ketamine-Induced Unconsciousness
Authors: Chen Yali , Li Siyang , Liang Xia , Zhang Jun 
Published: January 2022

BACKGROUND:
Ketamine anesthesia increased glucose metabolism in most brain regions compared to another intravenous anesthetic propofol. However, whether the changes in cerebral metabolic networks induced by ketamine share the same mechanism with propofol remains to be explored. The purpose of the present study was to identify specific features of metabolic network in rat brains during ketamine-induced subanesthesia state and anesthesia state compared to awake state.

METHODS:
We acquired fluorodeoxyglucose positron emission tomography (FDG-PET) images in 20 healthy adult Sprague-Dawley rats that were intravenously administrated saline and ketamine to achieve different conscious states: awake (normal saline), subanesthesia (30 mg kg−1 h−1), and anesthesia (160 mg kg−1 h−1). Based on the FDG-PET data, the alterations in cerebral glucose metabolism and metabolic topography were investigated by graph-theory analysis.

RESULTS:
The baseline metabolism in rat brains was found significantly increased during ketamine-induced subanesthesia and anesthesia. The graph-theory analysis manifested a reduction in metabolism connectivity and network global/local efficiency across cortical regions and an increase across subcortical regions during ketamine-induced anesthesia (nonparametric permutation test: global efficiency between awake and anesthesia, cortex: P = .016, subcortex: P = .015; global efficiency between subanesthesia and anesthesia, subcortex: P = .012).

CONCLUSIONS:
Ketamine broadly increased brain metabolism alongside decreased metabolic connectivity and network efficiency of cortex network. Modulation of these cortical metabolic networks may be a candidate mechanism underlying general anesthesia-induced loss of consciousness.
INOVAÇÃO E CONTRIBUIÇÃO DO DESIGN THINKING: MAPEAMENTO BIBLIOMÉTRICO SOBRE A PRODUÇÃO ACADÊMICA NAS BASES SCOPUS E WEB SCIENCE
Authors: Aragão Elisangela De Menezes , Jesus Vania De , Carvalho Ramon Santos , Santos Mario Jorge Campos dos 
Published: January 2022

Começam a despontar, nas diversas áreas de conhecimento, diferentes tipos de inovação, oriundos de metodologias como Design Thinking, que desempenham um papel importante nas organizações, funcionando como facilitadoras na apresentação de novas soluções que possibilitam melhores resultados. Este artigo tem o objetivo de apresentar a relação entre Inovação e metodologias para o despertar criativo, alinhada ao Design Thinking, por meio da produção acadêmica no período de 2015 a 2020, utilizando a bibliometria. Para o alcance do objetivo deste estudo, utilizaram-se indicadores bibliométricos na análise e avaliação dos artigos nas bases de dados Scopus e Web of Science. Obtiveram-se, na base Scopus, 92 artigos e, na Web of Science, 83, no período de 2015 a 2020, mostrando um espaço para as pesquisas neste contexto. Destaca-se pela quantidade de artigos o ano de 2018. Observou-se, por fim, que este tema é de interesse de várias áreas de conhecimentos, apesar de a maior concentração ser nas áreas administração de negócios, engenharia, ciência da computação e ciências sociais, outras áreas também têm contribuído com artigos, caracterizando que este é um tema multidisciplinar.
Lateral versus posterior surgical approach for the treatment of supracondylar humeral fractures in children: a systematic review and meta-analysis
Authors: Irianto Komang Agung , Pradana I Putu Gede Pradnyadewa , De Vega Brigita 
Published: January 2022

Background: Supracondylar humeral fracture (SHF) is the most common type of fracture in children. Moreover, lateral and posterior surgical approaches are the most frequently chosen approaches for open reduction surgery in displaced SHF when C-arm is unavailable. However, previous literature showed mixed findings regarding functional and cosmetic outcomes. Currently, no systematic review and meta-analysis has compared these two procedures. Methods: Our protocol was registered at PROSPERO (registration number CRD42021213763). We conducted a comprehensive electronic database search in MEDLINE, EMBASE, and CENTRAL. Two independent reviewers screened the title and abstract, followed by full-text reading and study selection based on eligibility criteria. The quality of the selected studies was analyzed with the ROBINS-I tool. Meta-analysis was carried out to compare the range of motion (functional outcome) and cosmetic outcome according to Flynn’s criteria. This systematic review was conducted based on PRISMA and Cochrane handbook guidelines. Results: Our initial search yielded 163 studies, from which we included five comparative studies comprising 231 children in the qualitative and quantitative analysis. The lateral approach was more likely to result in excellent (OR 1.69, 95% CI [0.97-2.93]) and good (OR 1.12, 95% CI [0.61-2.04]) functional outcomes and less likely to result in fair (OR 0.84, 95% CI [0.34-2.13]) and poor (OR 0.42, 95% CI [0.1-1.73]) functional outcomes compared to the posterior approach. In terms of cosmetic results, both approaches showed mixed findings. The lateral approach was more likely to result in excellent (OR 1.11, 95% CI [0.61-2.02]) and fair (OR 1.18, 95% CI [0.49-2.80]) but less likely to result in good (OR 0.79, 95% CI [0.40-1.55]) cosmetic outcomes. However, none of these analyses were statistically significant (p> 0.05). Conclusion: Lateral and posterior surgical approaches resulted in satisfactory functional and cosmetic outcomes. The two approaches are comparable for treating SHF in children when evaluated with Flynn’s criteria.
Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics
Authors: Yadrykhins'ky Vladyslav , Georgiou Charis , Brenk Ruth 
Published: January 2022

Background: FabB (3-oxoacyl-[acyl-carrier-protein] synthase 1) is part of the fatty acid synthesis II pathway found in bacteria and a potential target for antibiotics. The enzyme catalyses the Claisen condensation of malonyl-ACP (acyl carrier protein) with acyl-ACP via an acyl-enzyme intermediate. Here, we report the crystal structure of the intermediate-mimicking Pseudomonas aeruginosa FabB (PaFabB) C161A variant. Methods: His-tagged PaFabB C161A was expressed in E. coli Rosetta DE3 pLysS cells, cleaved by TEV protease and purified using affinity and size exclusion chromatography. Commercial screens were used to identify suitable crystallization conditions which were subsequently improved to obtain well diffracting crystals. Results: We developed a robust and efficient system for recombinant expression of PaFabB C161A. Conditions to obtain well diffracting crystals were established. The crystal structure of PaFabB C161A was solved by molecular replacement at 1.3 Å resolution. Binding site comparison between PaFabB and PaFabF revealed a conserved malonyl binding site but differences in the fatty acid binding channel. Conclusions: The PaFabB C161A crystal structure can be used as a template to facilitate the design of FabB inhibitors.
Testing for sensory threshold in drinking water with added calcium: a first step towards developing a calcium fortified water
Authors: Cormick Gabriela , Matamoros Natalia , Romero Iris B. , Perez Surya M. , White Cintia , Watson Dana Z. , Belizán José M. , Sosa Miriam , Gugole Ottaviano M. Fernanda , Elizagoyen Eliana , Garitta Lorena 
Published: January 2022

Background: Food fortification is an effective strategy that has been recommended for improving population calcium inadequate intakes. Increasing calcium concentration of water has been proposed as a possible strategy to improve calcium intake. The objective of this study was to determine the sensory threshold of different calcium salts added to drinking water using survival analysis. Methods: We performed the triangle test methodology for samples of water with added calcium using three different calcium salts: calcium chloride, calcium gluconate and calcium lactate. For each salt, a panel of 54 consumers tested seven batches of three water samples. Data were adjusted for chance and sensory threshold was estimated using the survival methodology and a discrimination of 50%. Results: The threshold value estimation for calcium gluconate was 587 ± 131 mg/L of water, corresponding to 25% discrimination, for calcium lactate was 676 ± 186 mg/L, corresponding to 50% discrimination, and for calcium chloride was 291 ± 73 mg/L, corresponding to 50% discrimination. Conclusions: These results show that water with calcium added in different salts and up to a concentration of 500 mg of calcium/L of water is feasible. The calcium salt allowing the highest calcium concentration with the lowest perceived changes in taste was calcium gluconate. Future studies need to explore stability and acceptability over longer periods of time.
Effect of taurine administration on symptoms, severity, or clinical outcome of dilated cardiomyopathy and heart failure in humans: a systematic review
Authors: McGurk Kathryn A. , Kasapi Melpomeni , Ware James S. 
Published: January 2022

Background: Taurine, 2-aminoethanesulfonic acid, is an amino acid found in animal products. Taurine is produced for human consumption as a supplement and ingredient in beverages. Supplementation is a safe, inexpensive, and effective treatment for dilated cardiomyopathy (DCM) in domestic mammals, however it is currently unlicensed in Europe and the United States for human medical treatment. Recent genome-wide association studies of DCM have identified the locus of the taurine transporter (SLC6A6). To assess whether taurine supplementation may be a novel therapeutic option for DCM, we undertook a systematic review. Methods: Four electronic databases (PubMed, Cochrane Central Register, Web of Science, Biomed Central) were searched until 11/03/21. Included studies of human participants reported measured phenotypes or symptoms for cardiomyopathy, heart failure (HF), or altered left ventricle structure or function, administering taurine in any formulation, by any method. Non-English articles were excluded. Meta-analysis was completed in R software (version 3.6.0). The Newcastle-Ottawa Scale quality assessment score (NOQAS) tool was used to assess bias. Results: 285 articles were identified, of which eleven met our criteria for inclusion. Only one paper was deemed “high quality” using the NOQAS tool. Taurine supplementation varied across studies; by dose (500 mg to 6g per day), frequency (once to thrice daily), delivery method (tablet, capsule, drink, powder), and duration (2 to 48 weeks). Patient inclusion was all-cause HF patients with ejection fraction (EF) <50% and no study was specific to DCM. While improvements in diastolic and systolic function, exercise capacity, and haemodynamic parameters were described, only EF and stroke volume were measured in enough studies to complete a meta-analysis; the association was not significant with all-cause HF (P<0.05). No significant safety concerns were reported. Conclusions: A formal clinical trial is needed to address whether taurine supplementation is beneficial to the approximately 1/250 individuals with DCM in the population.
How IT Investments Help Hospitals Gain and Sustain Reputation in the Media: The Role of Signaling and Framing
Authors: Salge Torsten Oliver , Antons David , Barrett Michael , Kohli Rajiv , Oborn Eivor , Polykarpou Stavros 
Published: January 2022

Practice- and Policy-Oriented Abstract Understanding how IT investments help organizations to build and sustain reputation is of particular relevance for healthcare practitioners and policy makers because patients are often unable to assess the quality of care, relying instead on the reputation of health service providers in the media, such as newspapers. As information intermediaries, journalists detect, aggregate, and translate the weaker signals for quality, such as state-of-the-art IT, that a hospital emanates. Our analysis of 152 hospital organizations in England, complemented by interviews with healthcare journalists, shows that journalists write less negatively about hospitals when healthcare organizations’ IT equipment investments are high. This implies that investments in IT equipment can buffer hospitals from negative press, thereby helping them to gain and maintain a strong reputation in the media. Practitioners and policy makers may incorporate the reputational effect of IT when making investment decisions and further amplify such IT investment through press releases, corporate reports, and media interactions.
Global Public Policy studies
Authors: Porto de Oliveira Osmany 
Published: January 2022

Globalisation has helped to intensify the international flow of people, information and policies. Following this process there has been increasing global concern regarding problems in areas such as immigration, health, poverty, among others. Various agents are transnationally engaged in common responses to these issues. The classic definition of public policies is related to actions undertaken by governments to solve the problems within their jurisdictions. However, often problems do not respect national boundaries. Sometimes, policies need to involve other nations. This article discusses the main issues, concepts and challenges in the study of global public policies.
First, the article presents a review of the existing literature. Second, it introduces the key agents and agendas of global public policy. The discussion section focuses on the latest challenges and opportunities for research in Global Public Policy studies. Finally, new avenues of research are introduced, such as the dimension of power, the impact of the far-right and the outbreak of the COVID-19 pandemic.
Investigation on the thermal blooming effect in a high power spectral beam
combining fiber laser system
Authors: Zheng Ye , Liu Xiaoxi , He Miao , Zhang Lin , Yu Miao , Li Siyuan , Ma Ziyang , Wang Junlong , Wang Xuefeng 
Published: January 2022

We demonstrate the influence of the thermal blooming effect on the far-field beam
quality in a seven-channel spectral beam combining system. Stimulated
Raman scattering in the incident narrow-linewidth fiber amplifier is
verified to be the dominant factor that induces thermal blooming in
the beam combining system. When the power density of
Raman light reaches only

180

W

/

c
m

2

, the peak intensity of the far-field
beam reduces severely and the beam distribution profile spreads. We
reveal that

H

2

O

content in the atmosphere has a
positive relationship with the thermal blooming effect and study the
influence of the humidity on the thermal blooming effect. The
influence of the optical path length on the thermal blooming effect is
also revealed. The result shows that the focusing property of the
far-field beam degrades gradually as the optical path length increases
from 100 to 450 mm. The results are conducive to optimize the beam
quality of spectral beam combining.
El fashion film como acción de la marca. El caso de Europa II en Vogue
Authors: Hernández-Herrera María , Gil-Ruiz Francisco-José , García-Guardia María-Luisa , Ayestarán-Crespo Raquel 
Published: January 2022

Este trabajo estudia el fashion film como herramienta de marketing a través del estudio del cortometraje Europa II de Vogue. En primer lugar, la investigación profundiza en la moda, en la marca Vogue, en la propia naturaleza del fashion film como formato publicitario, y en la importancia de las asociaciones de marca. En segundo lugar, se lleva a cabo un estudio exploratorio que identifica las asociaciones de la marca Vogue presentes en Europa II. La metodología empleada parte de un análisis semiótico centrado en extraer aquellas asociaciones (referencias y valores culturales latentes en él) desde la propuesta narrativa de Europa II, identificando así los significados presentes en su narrativa, aquellos que en definitiva hablan de la marca, de cómo quiere ser percibida. Hecho esto, se contrastaron las asociaciones resultantes mediante una entrevista a siete expertos en el ámbito del marketing y/o la comunicación. De entre las principales conclusiones, cabe destacar que Europa II sirve a Vogue para rejuvenecer su target y, por ende, conectar con nuevos públicos. Las asociaciones de marca aportan de este modo un punto de inflexión en cuanto al poder persuasivo de Europa II, conectando el análisis narrativo con el significado de la marca.
Primary Signet Ring Cell Carcinoma of the Ileal Pouch
Authors: Tetangco Eula Plana , Krogh Katrina , Yang Guang-Yu , Bellaguarda Emanuelle 
Published: January 2022

ABSTRACT
A 55-year-old man with a history of ulcerative colitis status post ileal pouch-anal anastomosis underwent evaluation for pouchitis. He was found to have signet ring cell cancer within the pouch. Primary cancers of the ileal pouch are rare. Signet ring cell carcinoma is a rare form of adenocarcinoma that can involve the gastrointestinal tract and other organs. We present a case of a signet ring cell carcinoma arising from an ileal pouch.
«Система социологии» Питирима Сорокина и системно-коммуникативный подход
Authors: Антоновский Александр Юрьевич , Бараш Раиса Эдуардовна 
Published: January 2022

В статье реконструируется ряд идей русско-американского социолога и философа Питирима Сорокина, сформулированных в российский период его творчества. Авторы анализируют программу автономизации социологии как трансдисциплинарной науки и показывают, что Сорокину удалось сформулировать фундаментальные положения системно-коммуникативного подхода в социальной теории, зафиксировать важнейшие предпосылки кристаллизации современного коммуникативно дифференцированного общества. Используя достижения современного ему естествознания, психологии, философии, лингвистики, эволюционной теории, Сорокин описал позитивную программу системно-коммуникативного подхода к исследованию общества, которая фактически реализовалась и тем самым верифицировалась лишь десятилетия спустя в рамках коммуникативной теории Никласа Лумана. Эта программа включала в себя анализ «минимального проявления» общества, которое получило название «взаимодействие». Это понятие мы отожествляем с современным понятием «коммуникации».
Статья представляет собой частично переработанную версию английского текста Antonovskiy A.Y. (2020) Sorokin Pitirim Revisited. His place in Social Philosophy as a Transdisciplinary Thinker. Journal of Siberian Federal University, Social Sciences. Vol. 8. No. 13. P. 1250—1263; печатается с разрешения этого журнала.
Hodnocení vzdělávacího přínosu škol pomocí přidané hodnoty: srovnání čtyř evropských zemí
Authors: Potužníková Eva 
Published: January 2022

Cílem práce je na základě porovnání situace ve čtyřech evropských vzdělávacích systémech (Anglie, Francie, Norsko, Polsko) poukázat na možnosti, ale i rizika spojená s evaluací škol na základě přidané hodnoty.
Metody. Přístupy jednotlivých zemí jsou porovnány podle předem určeného souboru kritérií. Zdrojem dat je technická dokumentace o modelech přidané hodnoty, webové portály pro zveřejňování výsledků a texty o vývoji modelů a využívání dat o přidané hodnotě.
Výsledky. Preferovaným zdrojem dat pro výpočet přidané hodnoty jsou standardizované testy či zkoušky. Dostupnost dat ovlivňuje volbu vzdělávacího stupně, hodnocených vzdělávacích oblastí (předmětů) i zařazení kontextových proměnných. Při zveřejňování přidané hodnoty země brání otevřenému srovnávání škol, netvoří žebříčky a přiznávají statistickou nejistotu spojenou s měřením. Informace o přidané hodnotě slouží jako zpětná vazba školám.
Závěry. Indikátory přidané hodnoty jsou spravedlivým ukazatelem vzdělávacího přínosu škol, s jejich zaváděním jsou však spojena rizika jako vynechání důležitých proměnných kvůli nedostupnosti dat, nedostatek odborných kapacit pro implementaci a rozvoj metody a malá využitelnost pro zlepšování kvality vzdělávání.
Intervence české vzdělávací politiky ve vztahu k výzkumně doloženým poznatkům a doporučením: případ požadavků na kvalifikaci učitele
Authors: Spilková Vladimíra , Reimannová Irena 
Published: January 2022

Cílem studie je analýza přístupu české vzdělávací politiky ke kvalifikačním požadavkům na vstup do učitelské profese v souvislosti s aktuálně projednávanou novelou zákona č. 563/2004 Sb., o pedagogických pracovnících, a zejména jejím kontroverzním § 9a odst. 1, který otevírá učitelskou profesi vysokoškolsky vzdělaným odborníkům bez pedagogické kvalifikace. Na případu legislativního procesu v daném tématu je dokumentován a analyzován přístup české vzdělávací politiky k profesi učitele v kontextu vztahů vrcholné decizní sféry k výzkumným zjištěním, mezinárodním trendům a strategiím relevantním pro kvalitu učitelů v 21. století.
Zkoumání uvedeného případu vzdělávací politiky je založeno na metodologii desk research. Klíčové zdroje dat představují dokumenty: legislativní (různé verze novely – sněmovní a senátní tisk novely, pozměňovací návrhy, stenozápisy z jednání obou komor Parlamentu ČR), dokumenty odborné a strategické (na národní i evropské úrovni), MŠMT, stanoviska důležitých aktérů a tiskové zprávy (profesní asociace, odborníci, neziskové organizace, příspěvky na sociálních sítích), mailová komunikace jedné z autorek příspěvku s poslanci a senátory.
V diskusi výsledků jsou kriticky reflektovány obsah a způsob zdůvodňování devalvace kvalifikačních požadavků na učitele ze strany politiků. Je zhodnocena relevance a korektnost hlavních důvodů prezentovaných předkladatelem novely – MŠMT a dalšími klíčovými aktéry legislativního procesu. Dále míra využití relevantních výzkumných dat a doporučení v procesu tvorby návrhu a politického rozhodování v otázce zákonných požadavků na kvalifikaci učitele.
Pelvic congestion syndrome: historical aspects and a modern view on the problem (a literature review)
Authors: Nykonenko A. O. , Havrylenko B. S. 
Published: January 2022

Pelvic congestion syndrome is a relatively recent, but actual and separate nosological form. Pelvic varicocele is a form of varicose disease, which is increasingly regarded as the main cause of chronic pelvic pain in women with various clinical manifestations. A woman with chronic pelvic pain is a difficult patient with combative behavior, who contacts with physicians in various specialties. There are many causes of chronic pelvic pain, but pelvic congestion syndrome has a special place. In recent years, in addition to widespread use of diagnostic radiology, the relevance of this pathology is beyond any doubt.
The aim of the study was to summarize and present literature data on the etiology, pathogenesis, clinical manifestations, diagnosis and treatment of pelvic congestion syndrome by analyzing the literature data.
Materials and methods. A non-systematic review was conducted using PubMed, Web of Science, Google and Google Scholar databases. The review included free full-text articles published between 1974 and 2021 using key words: pelvic congestion syndrome, pelvic varices, pelvic venous disorders, pelvic varicocele, pelvic venous stasis, chronic pelvic pain, gonadal veins, ovarian veins, vena ovarica, Nutcracker syndrome, May–Thurner syndrome.
Conclusions. Pelvic congestion syndrome is still a rarely diagnosed pathology in patients with chronic pelvic pain. Detailed medical history, physical examination as well as maintaining diagnostic algorithm would allow the disease to be diagnosed correctly and timely. The choice of method for surgical intervention is a key point in the treatment of patients with pelvic congestion syndrome, but today there are no criteria for the choice of one, so the problem is far from being resolved and requires further study and research.