bluuebunny/crossref_metadata_2025_split huggingface dataset:
The oldest fossil record of Pseudopsinae from the Lower Cretaceous Yixian Formation of northeastern China (Coleoptera: Staphylinidae: Pseudopsinae)
Authors: Liu Yuchu , Tihelka Erik , Cai Chenyang , Tian Li 
Published: March 2022

AbstractThe Cretaceous witnessed a radiation of rove beetles (Staphylinidae), the most species-rich beetle family. Although most staphylinid subfamilies have been documented from Cretaceous strata over the world, there has been no fossil record of the subfamily Pseudopsinae until a recently reported fossil from the 99-Ma-old Myanmar amber. Here we describe a new compression fossil from the Lower Cretaceous Yixian Formation of northeastern China. It is described as Cretaceonanobius fossilis. gen. et sp. nov. and assigned to the extant subfamily Pseudopsinae, based on the well-preserved carinae on the pronotum, a carina on ventrites II and III, and distinctly separated mesocoxae. The discovery of Cretaceonanobius fossilis gen. et sp. nov. backdates the earliest fossils record of Pseudopsinae to 125 Ma in the Northern Hemisphere and sheds new lights on the evolution history and paleobiogeography of this subfamily.
VO2-based ultra-reconfigurable intelligent reflective surface for 5G applications
Authors: Matos Randy , Pala Nezih 
Published: March 2022

AbstractAs demand for higher capacity wireless communications increases, new approaches are needed to improve capacity. The lack of configurable radio platforms and power consumed to create new signals are some of the limitations preventing further advancements. To address these limitations, we propose an Ultra-Reconfigurable Intelligent Surface (URIS) platform based on the metal-to-insulator transition property of VO2. A VO2layer is placed on a high-density micro-heater matrix consisting of pixels that can be electronically switched on. With this manner of control, heat can be transferred to selected areas of the VO2layer and convert it to highly conductive metallic phase. This technique allows dynamically changing the shape of the reflection surface with high speed. We numerically investigated the heat activated switching and RF reflection characteristics of a reflectarray designed for potential 5G applications operating at 32 GHz. It consists of heating pixels with the size of 40 × 40 μm which can generate metallic VO2patches or arbitrary shapes with ~ 100 × 100 μm spatial resolution. Our analyses resulted in large phase range of ~ 300° and approximate losses of −2 dB. The proposed device can serve as a novel platform for ultra-reconfigurable reflectarrays, other IRSs, and various wide spectral range RF applications.
Genetic variant located on chromosome 17p12 contributes to prostate cancer onset and biochemical recurrence
Authors: Pavel Anca Gabriela , Stambouli Danae , Gener Ismail , Preda Adrian , Anton Gabriela , Baston Catalin 
Published: March 2022

AbstractThe genetic contribution to prostate cancer (PC) onset and clinical heterogeneity has an important impact on the disease stratification accuracy. Despite the fact that radical prostatectomy (RP) is an effective treatment for localized PC, a considerable number of individuals develop biochemical recurrence (BCR) following surgery. In the present study, we decided to investigate the significance of genetic variability in a homogeneous group of Romanian men and to determine if genotyping could provide information regarding the possible implications of rs4054823 susceptibility loci in PC progression and outcome. A total of 78 samples from both PC and benign prostatic hyperplasia (BPH) patients were genotyped. The genotype frequencies were examined to see if there was a link between the 17p12 SNP and PC disease. When compared to the BPH group, the PC group had a significantly higher frequency of the T risk variant (P = 0.0056) and TT genotype (P = 0.0164). Subsequent analysis revealed that the TT genotype had a significantly higher frequency among younger PC patients based on their age at diagnosis and that it was related with a greater probability of BCR (P = 0.02). According to our findings, the TT genotype appears to be a risk factor for early-onset PC and a potential predictor for BCR after RP.
Propensity score matching analysis to evaluate efficacy of polyethylene oxide adhesive on preventing delayed bleeding after gastric endoscopic submucosal dissection
Authors: Yu Yang , Hu Tong , Kuai Xiaoyi , Liu Xiaoyu , Li Rui , Zhou Chunli 
Published: March 2022

AbstractRegardless of technical advancements, delayed bleeding is still a common adverse event after gastric endoscopic submucosal dissection (ESD), often occurring in the early postoperative phase. This study aimed to evaluate the efficacy of a newly designed polyethylene oxide (PEO) adhesive for preventing delayed gastric bleeding. Patients who underwent gastric ESD between December 2017 and December 2020 at three Chinese institutions were retrospectively reviewed. Patients receiving PEO application on gastric post-ESD ulcers were included in the PEO group, and patients without this procedure were included in the control group. To minimize potential bias, propensity score matching was performed, and sex, age, lesion size, lesion morphology, ulceration, localization, procedure time, frequency of major intraoperative bleeding, resected specimen size, lesion histopathology, submucosal invasion and the taking of antithrombotic drugs were included as matching factors. The incidence of delayed bleeding and time to bleeding were compared between both groups. After propensity score matching, 270 patients (135 per group) were included in the analysis. The delayed bleeding rate in the PEO group was significantly lower than that in the control group (1.5%, 2/135 vs. 8.9%, 12/135, P = 0.006). The median time (range) to bleeding was 4.5 (4–5) days in the PEO group and 2 (1–15) days in the control group, with no significant difference (P = 0. 198). PEO demonstrated a significant effect in reducing the rate of delayed bleeding. Further study is warranted to confirm the efficacy of PEO for bleeding that occurs in the early phase after gastric ESD.
Large-scale societal dynamics are reflected in human mood and brain
Authors: Lebedev Alexander V. , Abé Christoph , Acar Kasim , Deco Gustavo , Kringelbach Morten L. , Ingvar Martin , Petrovic Predrag 
Published: March 2022

AbstractThe stock market is a bellwether of socio-economic changes that may directly affect individual well-being. Using large-scale UK-biobank data generated over 14 years, we applied specification curve analysis to rigorously identify significant associations between the local stock market index (FTSE100) and 479,791 UK residents’ mood, as well as their alcohol intake and blood pressure adjusting the results for a large number of potential confounders, including age, sex, linear and non-linear effects of time, research site, other stock market indexes. Furthermore, we found similar associations between FTSE100 and volumetric measures of affective brain regions in a subsample (n = 39,755; measurements performed over 5.5 years), which were particularly strong around phase transitions characterized by maximum volatility in the market. The main findings did not depend on applied effect-size estimation criteria (linear methods or mutual information criterion) and were replicated in two independent US-based studies (Parkinson’s Progression Markers Initiative; n = 424; performed over 2.5 years and MyConnectome; n = 1; 81 measurements over 1.5 years). Our results suggest that phase transitions in the society, indexed by stock market, exhibit close relationships with human mood, health and the affective brain from an individual to population level.
Structured transmittance illumination coherence holography
Authors: Mandal Aditya Chandra , Sarkar Tushar , Zalevsky Zeev , Singh Rakesh Kumar 
Published: March 2022

AbstractThe coherence holography offers an unconventional way to reconstruct the hologram where an incoherent light illumination is used for reconstruction purposes, and object encoded into the hologram is reconstructed as the distribution of the complex coherence function. Measurement of the coherence function usually requires an interferometric setup and array detectors. This paper presents an entirely new idea of reconstruction of the complex coherence function in the coherence holography without an interferometric setup. This is realized by structured pattern projections on the incoherent source structure and implementing measurement of the cross-covariance of the intensities by a single-pixel detector. This technique, named structured transmittance illumination coherence holography (STICH), helps to reconstruct the complex coherence from the intensity measurement in a single-pixel detector without an interferometric setup and also keeps advantages of the intensity correlations. A simple experimental setup is presented as a first step to realize the technique, and results based on the computer modeling of the experimental setup are presented to show validation of the idea.
Liquid metal droplet shuttling in a microchannel toward a single line multiplexer with multiple sensors
Authors: Shimizu Ayano , Kakehi Yugo , Bono Shinji , Konishi Satoshi 
Published: March 2022

AbstractMultiple sensors and actuators integrated in a small space, especially an elongated thin structure, require equivalent number of signal lines between microdevices, but there is limited space for signal wires. Thus, we propose a mechanism using a single microchannel where a liquid metal droplet moves and shuttles. A shuttling droplet switches multiple terminals of signal lines along a microchannel based on a traditional switching mechanism using a liquid metal droplet. Electrically conductive gallium alloy liquid metals (Galinstan) can flow in a microchannel due to their fluidity. The terminals consist of opposing electrode pairs in a microchannel. A change in a variable impedance connected to a terminal as a pseudo sensor can be read when a droplet flows in and connects electrode pairs. This paper presents switching and addressing objective terminals of chromium electrodes by a shuttling conductive droplet (500 µm in diameter and 10 mm long) in a microchannel (500 µm in diameter and 100 mm long). A demonstrated simple mechanism enables communication between multiple microdevices along a microchannel. We anticipate wide application of proposed mechanism toward a multiplexer, especially in microfluidic devices because of the advantages of utilizing microchannels as common microstructures for both microdevices and signal lines.
Vitamin D stimulates placental L-type amino acid transporter 1 (LAT1) in preeclampsia
Authors: Jia Xiaotong , Cao Yang , Ye Lingyu , Liu Xueqing , Huang Yujia , Yuan Xiaolei , Lu Chunmei , Xu Jie , Zhu Hui 
Published: March 2022

AbstractVitamin D insufficiency/deficiency has been linked to an increased risk of preeclampsia. Impaired placental amino acid transport is suggested to contribute to abnormal fetal intrauterine growth in pregnancies complicated by preeclampsia. However, if vitamin D-regulated amino acid transporter is involved in the pathophysiologic mechanism of preeclampsia has not been clarified yet. The aberrant expression of key isoform of L-type amino acid transporter LAT1 was determined by western blot and immunohistochemistry in the placenta from normotensive and preeclamptic pregnancies. The role for vitamin D on placental LAT1 expression was investigated through the exposure of HTR-8/SVneo human trophoblast cells to the biologically active 1,25(OH)2D3 and the oxidative stress-inducer cobalt chloride (CoCl2). Our results showed that placental LAT1 expression was reduced in women with preeclampsia compared to normotensive pregnancies, which was associated with decreased expression of vitamin D receptor (VDR). 1,25(OH)2D3 significantly upregulated LAT1 expression in placental trophoblasts, and also prevented the decrease of mTOR activity under CoCl2-induced oxidative stress. siRNA targeting VDR significantly attenuated 1,25(OH)2D3-stimulated LAT1 expression and mTOR signaling activity. Moreover, treatment of rapamycin specifically inhibited the activity of mTOR signaling and resulted in decrease of LAT1 expression. In conclusion, LAT1 expression was downregulated in the placenta from women with preeclampsia. 1,25(OH)2D3/VDR could stimulate LAT1 expression, which was likely mediated by mTOR signaling in placental trophoblasts. Regulation on placental amino acid transport may be one of the mechanisms by which vitamin D affects fetal growth in preeclampsia.
Origin and genetic analysis of stem rust resistance in wheat line Tr129
Authors: Sharma Jyoti Saini , Fetch Thomas G. , Ghazvini Habibollah , Rouse Matthew N. , Danilova Tatiana , Friebe Bernd , Hiebert Colin W. 
Published: March 2022

AbstractWheat line Tr129 is resistant to stem rust, caused by Puccinia graminis f. sp. tritici (Pgt). The resistance in Tr129 was reportedly derived from Aegilops triuncialis, but the origin and genetics of resistance have not been confirmed. Here, genomic in situ hybridization (GISH) showed that no Ae. triuncialis chromatin was present in Tr129. Genetic and phenotypic analysis was conducted on F2 and DH populations from the cross RL6071/Tr129. Seedlings were tested with six Pgt races and were genotyped using an Illumina iSelect 90 K SNP array and kompetitive allele specific PCR (KASP) markers. Mapping and phenotyping showed that Tr129 carried four stem rust resistance (Sr) genes on chromosome arms 2BL (Sr9b), 4AL (Sr7b), 6AS (Sr8a), and 6DS (SrTr129). SrTr129 co-segregated with markers for SrCad, however Tr129 has a unique haplotype suggesting the resistance could be new. Analysis of a RL6071/Peace population revealed that like SrTr129, SrCad is ineffective against three North American races. This new understanding of SrCad will guide its use in breeding. Tr129 and the DNA markers reported here are useful resources for improving stem rust resistance in cultivars.
Interferenceless coded aperture correlation holography with point spread holograms of isolated chaotic islands for 3D imaging
Authors: Dubey Nitin , Rosen Joseph 
Published: March 2022

AbstractInterferenceless coded aperture correlation holography (I-COACH) is an incoherent digital holographic technique with lateral and axial resolution similar to a regular lens-based imaging system. The properties of I-COACH are dictated by the shape of the system’s point response termed point spread hologram (PSH). As previously shown, chaotic PSHs which are continuous over some area on the image sensor enable the system to perform three-dimensional (3D) holographic imaging. We also showed that a PSH of an ensemble of sparse dots improves the system’s signal-to-noise ratio (SNR) but reduces the dimensionality of the imaging from three to two dimensions. In this study, we test the midway shape of PSH, an ensemble of sparse islands distributed over the sensor plane. A PSH of isolated chaotic islands improves the SNR of the system compared to continuous chaotic PSH without losing the capability to perform 3D imaging. Reconstructed images of this new system are compared with images of continuous PSH, dot-based PSH, and direct images of a lens-based system. Visibility, SNR, and the product of visibility with SNR are the parameters used in the study. We also demonstrate the imaging capability of a system with partial annular apertures. The reconstruction results have better SNR and visibility than lens-based imaging systems with the same annular apertures.
Synthesis and characterization of CoxFe1−xFe2O4 nanoparticles by anionic, cationic, and non-ionic surfactant templates via co-precipitation
Authors: Sangsuriyonk Kittipon , Paradee Nophawan , Rotjanasuworapong Kornkanok , Sirivat Anuvat 
Published: March 2022

AbstractThe cobalt ferrite nanoparticles (CoxFe1−xFe2O4) were synthesized by the surfactant templated co-precipitation method using various surfactants namely sodium dodecyl sulfate (SDS), hexadecyltrimethylammonium bromide (CTAB), and Tween20. Under the substitution, the CoxFe1−xFe2O4 particles were synthesized at various Co2+ and Fe2+ mole ratios (x = 1, 0.6, 0.2, and 0) with the SDS. The cobalt ferrite nanoparticles were characterized for their morphology, structure, magnetic, and electrical properties. All CoxFe1−xFe2O4 nanoparticles showed the nanoparticle sizes varying from 16 to 43 nm. In the synthesis of CoFe2O4, the SDS template provided the smallest particle size, whereas the saturated magnetization (Ms) of CoFe2O4 was reduced by using CTAB, SDS, and Tween20. For the CoxFe1−xFe2O4 as synthesized by the SDS template at 1.2 CMC, the Ms increased with increasing Fe2+ mole ratio. The highest Ms of 100.4 emu/g was obtained from the Fe3O4 using the SDS template. The Fe3O4 nanoparticle is potential to be used in various actuator and biomedical devices.
GSK3 inhibition circumvents and overcomes acquired lorlatinib resistance in ALK-rearranged non-small-cell lung cancer
Authors: Shimizu Yuki , Okada Koutaroh , Adachi Jun , Abe Yuichi , Narumi Ryohei , Uchibori Ken , Yanagitani Noriko , Koike Sumie , Takagi Satoshi , Nishio Makoto , Fujita Naoya , Katayama Ryohei 
Published: March 2022

AbstractAnaplastic lymphoma kinase (ALK) fusion is found in ~3%–5% of patients with non-small-cell lung cancers (NSCLCs). Although the third-generation ALK tyrosine kinase inhibitor (TKI) lorlatinib shows high clinical efficacy in ALK-positive NSCLC, most of the patients eventually relapse with acquired resistance. Recently, drug-tolerant persister (DTP) cells have been considered an important seed of acquired resistance cells. In this study, we established lorlatinib intermediate resistant cells from a patient-derived cell model. Glycogen synthase kinase 3 (GSK3) inhibitions significantly suppressed lorlatinib intermediate resistant cell growth. GSK3 inhibition also sensitized acquired resistance cells derived from alectinib-treated patients with or without secondary mutations to lorlatinib. Therefore, GSK3 plays a crucial role in developing acquired resistance against lorlatinib in ALK-positive NSCLC mediated by lorlatinib intermediate resistant cells and could be a potential molecular target to prevent acquired lorlatinib resistance and overcome ALK-TKI resistance.
Advanced preparation of fragment libraries enabled by oligonucleotide-modified 2′,3′-dideoxynucleotides
Authors: Medžiūnė Justina , Kapustina Žana , Žeimytė Simona , Jakubovska Jevgenija , Sindikevičienė Rūta , Čikotienė Inga , Lubys Arvydas 
Published: March 2022

AbstractThe ever-growing demand for inexpensive, rapid, and accurate exploration of genomes calls for refinement of existing sequencing techniques. The development of next-generation sequencing (NGS) was a revolutionary milestone in genome analysis. While modified nucleotides already were inherent tools in sequencing and imaging, further modification of nucleotides enabled the expansion into even more diverse applications. Herein we describe the design and synthesis of oligonucleotide-tethered 2′,3′-dideoxynucleotide (ddONNTP) terminators bearing universal priming sites attached to the nucleobase, as well as their enzymatic incorporation and performance in read-through assays. In the context of NGS library preparation, the incorporation of ddONNTP fulfills two requirements at once: the fragmentation step is integrated into the workflow and the obtained fragments are readily labeled by platform-specific adapters. DNA polymerases can incorporate ddONNTP nucleotides, as shown by primer extension assays. More importantly, reading through the unnatural linkage during DNA synthesis was demonstrated, with 25-30% efficiency in single-cycle extension.
Meine Blase lässt mich nicht los –
Homöopathie bei neurogener
Blasenfunktionsstörung
Authors: Pannek Jürgen , Pannek-Rademacher Susanne 
Published: March 2022

ZusammenfassungDie Integrität des Nervensystems ist Voraussetzung für eine
ungestörte Urinspeicherung und Blasenentleerung. Neurologische
Systemerkrankungen (z. B. Rückenmarkverletzungen, Multiple
Sklerose, Morbus Parkinson, Spina bifida, zerebrovaskulärer Insult)
führen in aller Regel zu einer neurogenen Blasenfunktionsstörung
(NBFS). Typische Folgen sind Harnwegsinfekte (HWI) und eine überaktive
Blase, die sowohl die Nierenfunktion schädigen als auch die
Lebensqualität der Betroffenen massiv beeinträchtigen
können.Die bisherigen Studien zeigen, dass durch klassische Homöopathie akute
HWI effektiv, effizient und nebenwirkungsarm therapiert werden können.
Bei 199 nichtfieberhaften HWI entschieden sich die Probanden in 104
Fällen für eine Antibiotikaeinnahme. In 78,8% waren die
Betroffenen nach der initialen Antibiotikabehandlung beschwerdefrei. In 95
HWI-Episoden entschieden sich die Betroffenen für eine
nichtantibiotische Therapie. Von den 59 HWI unter homöopathischer
Behandlung waren die Patienten in 40 Episoden (67,8%) nach der
Erstbehandlung symptomfrei. Die Erfolgsraten der antibiotischen und der
nichtantibiotischen Therapien waren nicht signifikant unterschiedlich.Zudem ist Homöopathie auch eine wirksame Prophylaxestrategie bei
rezidivierenden HWI. Die Anzahl der HWI/Jahr reduzierte sich in der
Gruppe mit homöopathischer Behandlung signifikant, während die
HWI-Frequenz in der Kontrollgruppe über die Studiendauer
unverändert blieb. Somit kann die Homöopathie wesentlich zur
Reduktion des Einsatzes von Antibiotika beitragen. Bei der Therapie der
Detrusorüberaktivität konnte kein Einfluss der
homöopathischen Therapie auf urodynamische Parameter nachgewiesen
werden.Aufgrund der unspezifischen und untypischen Symptome bei Menschen mit
Rückenmarkverletzung sind gute medizinische Kenntnisse der
Homöopath*innen unabdingbar, um die geschilderten Symptome
einordnen zu können. Für eine erfolgreiche Zusammenarbeit ist
eine wechselseitig wertschätzende Beziehung zwischen allen Beteiligten
eine Grundvoraussetzung.
„Die Prostata ist mein
Gefühlsventil“
Authors: Diez Susanne 
Published: March 2022

ZusammenfassungIn dem nachfolgenden Artikel wird die langjährige Krankheitsgeschichte
eines Patienten dargestellt, der unter einer rezidivierenden chronischen
Prostatitis leidet. Die erfolgreiche homöopathische Behandlung wird
differenzialdiagnostisch beleuchtet. Die Autorin, die zwischenzeitlich auch die
Empfindungsmethode nach Yakir verwendet, diskutiert die Arzneimittelwahl des
damaligen Falles nach ihren heutigen Erkenntnissen. Dabei erläutert sie
die psychischen Hintergründe des Patienten für die
langjährige Prostatitis, die ausschlaggebend für die letztlich
erfolgreiche Behandlung auf allen Ebenen war. Chimaphila umbellata als hier
verordnete Akutarznei wird dabei genauer betrachtet.
What causes COVID-19 vaccine hesitancy? Ignorance and the lack of bliss in the United Kingdom
Authors: Bullock Josh , Lane Justin E. , Shults F. LeRon 
Published: March 2022

AbstractUnderstanding vaccine hesitancy has become increasingly important during the COVID-19 pandemic as governments around the globe have been struggling to convince portions of their populations to participate in vaccination protocols. Here we report on a nationally representative survey of the United Kingdom in which data revealed that individuals showed more willingness to take fictitious vaccines (putatively produced by the US government Medicare program and the now defunct healthcare company Theranos) than to take the Sputnik and Sinovac vaccines (developed by the Russian and Chinese governments respectively). The data indicate that the critical factor in vaccine hesitancy among the respondents was anxiety rather than familiarity with vaccines.