bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of crude glycerin levels on meat quality and carcass characteristics of crossbred Boer goats
Authors: Bezerra Higor Fábio Carvalho , Santos Edson Mauro , de Carvalho Gleidson Giordano Pinto , de Oliveira Juliana Silva , de Moura Zanine Anderson , Pinho Ricardo Martins Araujo , de Araújo Maria Leonor Garcia Melo Lopes , Perazzo Alexandre Fernandes , Ferreira Daniele de Jesus 
Published: March 2022

AbstractThis study assessed the effects of four levels of crude glycerin (0, 50, 100, and 150 g/kg dry matter (DM) basis) in the diet of Boer crossbred goat kids on the qualitative and quantitative carcass characteristics as well as meat quality. Thirty‐two crossbred, castrated Boer x undefined breed goat kids with an initial average weight of 17.8 ± 2.2 kg between 3 and 4 months of age were distributed across a complete randomized experiment with four treatments and eight replicates. The DM intake linearly decreased (p < .05) as the crude glycerin inclusion level in the diet increased. Crude glycerin levels decreased (linear effect, p < .05) empty body weight, hot dressing percentage, and cold dressing percentage. Conformation and subcutaneous fat thickness were not affected (p > .05) by dietary crude glycerin. Crude glycerin levels decreased (linear effect, p = .03) rib eye area of the Longissimus dorsi muscle, however, did not affect color, cooking loss, and shear force. The crude glycerin can be included up to 50 g/kg DM in the diet of crossbred Boer goats without negatively affecting carcass characteristics and meat quality. It can be recommended as an energy source in finishing diets.
The role of network‐forming collagens in cancer progression
Authors: Zhang Jin , Liu Jieya , Zhang Hongying , Wang Jiao , Hua Hui , Jiang Yangfu 
Published: March 2022

AbstractCollagens are the main components of extracellular matrix in the tumor microenvironment. Both fibrillar and nonfibrillar collagens are involved in tumor progression. The nonfibrillar network‐forming collagens such as type IV and type VIII collagens are frequently overexpressed in various types of human cancers, which promotes tumor cell proliferation, adhesion, invasion, metastasis and angiogenesis. Studies on the roles of these collagens have shed light on the mechanisms underpinning the effects of this protein family. Future research has to explicit the role of network‐forming collagens with respect to cancer progression and treatment. Herein, we review the regulation of network‐forming collagens expression in cancer; the roles of network‐forming collagens in tumor invasion, metastasis and angiogenesis; and the clinical significance of network‐forming collagens expression in cancer patients.
Analysis of the implementation of maternal death surveillance and response in Chad
Authors: Kouanda Seni , Ouedraogo Olivia M.A. , Tchonfiene Passiri P. , Lhagadang Foumsou , Ouedraogo Leopold , Conombo Kafando Ghislaine S. 
Published: March 2022

AbstractObjectiveTo analyze implementation of the maternal death surveillance and response (MDSR) strategy in Chad.MethodsSecondary data analysis of results from a cross‐sectional study involving semistructured interviews with decision‐makers at central, regional, and district levels, health providers, and technical and financial partners, and a document review. Data collection took place from June–July 2017.ResultsMaternal death reporting was incorporated into the Integrated Disease Surveillance and Response system but did not include neonatal deaths nor maternal and neonatal deaths in communities. Underreporting of maternal deaths owing to fear of repercussions was evident, likely associated with maternal deaths reported at monthly meetings held by the country's President with stakeholders in the health sector. Maternal death reviews were only undertaken between 2015 and 2016 in four regions of Chad and ceased in mid‐August 2016. Reasons include the departure of foreign obstetricians, lack of motivation among health workers, weak accountability at all levels of the health system, organizational issues, and nonimplementation of review recommendations.ConclusionStrong action is needed by the Ministry of Health to revive implementation of the MDSR system.
Seroprevalence of SARS‐CoV‐2 antibodies among first‐trimester pregnant women during the second wave of the pandemic in India
Authors: Sharma Kandala Aparna , Singh Nilanchali , Hillman Sara , Mathur Purva , Yadav Kapil , Garg Anapti , Dadhwal Vatsla , Bhatla Neerja 
Published: March 2022

AbstractObjectiveData on the immune response to SARS‐CoV‐2 during pregnancy are lacking and the potential role and effect of SARS‐CoV‐2 vaccination in pregnancy is yet to be completely investigated.MethodThis is a cross‐sectional observational study wherein pregnant women were tested for SARS‐CoV‐2 immunoglobulin M and immunoglobulin G levels, irrespective of their infective status or presence or symptomatology.ResultOf the 220 pregnant women tested, 160 (72.7%) were SARS‐CoV‐2 IgG positive, 37 (16.8%) were SARS‐CoV‐2 IgM positive and 27 (16.9%) were both IgG and IgM positive. The average antibody titer found was 10.49 BAU/ml (±14.0) and 0.6 (±0.55) for anti‐SARS‐CoV‐2 IgG and IgM non neutralizing antibodies respectively. ROC analysis for SARS‐CoV‐2 IgG positivity showed a cut‐off value of 1.19 with a sensitivity of 99.3% (0.99 AUC, 95% CI) and specificity of 98.3% (0.99 AUC, 95% CI), respectively. Similarly, ROC analysis for SARS‐CoV‐2 IgM positivity showed a cut‐off value of 1 with a sensitivity of 97.3% (0.99 AUC, 95% CI) and specificity of 98.9% (0.99 AUC, 95% CI), respectively.ConclusionFirst trimester sero‐molecular screening suggests a high prevalence of COVID antibodies in the study population of pregnant women in the first trimester, without the patients being symptomatic.
OPEC study: An international multicenter study of ovarian preservation in endometrial cancers
Authors: Akgor Utku , Ayhan Ali , Shushkevich Alexander , Ozdal Bulent , Angelou Kyveli , Akbayır Ozgur , Kaidarova Dilyara , Ulrikh Elena , Stepanyan Artem , Ortac Fırat , Aliyev Shamistan , Ozgul Nejat , Taranenka Siarhei , Haberal Ali , Salman Coskun , Seyhan Alper , Selcuk Ilker , Haidopoulos Dimitrios , Akıllı Huseyin , Bolatbekova Raikhan , Alaverdyan Areg , Taskin Salih , Murshudova Sabina , Batur Meltem , Berlev Igor , Gultekin Murat 
Published: March 2022

AbstractObjectiveTo evaluate the feasibility and oncological safety of ovarian preservation in early stage endometrial adenocarcinoma (EC) patients aged 40 and below.MethodsA total of 11 institutions from eight countries participated in the study. 169 of 5898 patients aged ≤40 years were eligible for the study. Patients with EC treated between March 2007 and January 2019 were retrospectively assessed.ResultsThe median duration of follow‐up after EC diagnosis was 59 months (4–187). Among 169 participants, ovarian preservation surgery (OPS) was performed in 54 (31.9%), and BSO was performed in 115 (68.1%) patients. Although patients younger than 30 years of age were more likely to have OPS than patients aged 30 to 40 years (20.4% vs. 9.6%, P = 0.021), there was no significant difference by the mean age. There were no other relevant baseline differences between OPS and BSO groups. The Kaplan–Meier analysis revealed no difference in either the overall survival (P = 0.955) or recurrence‐free survival (P = 0.068) among patients who underwent OPS, and BSO.ConclusionOPS appears to be safe without having any adverse impact on survival in women aged ≤40 years with FIGO Stage I EC.
Do we over‐diagnose ADHD in North America? A critical review and clinical recommendations
Authors: Gascon Abigaëlle , Gamache Dominick , St‐Laurent Diane , Stipanicic Annie 
Published: March 2022

AbstractThere has been a marked increase in the prevalence of attention‐deficit/hyperactivity disorder (ADHD) in the last 25 years in North America. Some see this trend as positive and believe that it reflects a better identification of ADHD and even think that the disorder is still under‐diagnosed. Others, however, contend that ADHD is over‐diagnosed. To help mental health clinicians to maintain an informed and nuanced perspective on this debate, this critical review aims to (1) summarize empirical results on factors that might contribute to increase the number of ADHD diagnoses and (2) propose clinical recommendations coherent with these findings to improve clinical practices for ADHD assessment and treatment. We conclude that artifactual factors such as current formulation of diagnostic criteria, clinical practices, and inordinate focus on performance, which is rampant in North America, likely contribute to inflated prevalence rates.
Residential mobility, neighborhood cohesion, and depressive symptoms among urban‐dwelling African American adolescents
Authors: Gepty Andrew A. , Lambert Sharon F. , Milam Adam J. , Ialongo Nicholas S. 
Published: March 2022

AbstractMechanisms linking residential mobility and depressive symptoms among urban‐dwelling African American adolescents have received little attention. This study examined neighborhood cohesion as a possible mechanism. Participants were 358 urban‐dwelling African American adolescents (Mage = 14.78; SD = 0.34) who reported their neighborhood cohesion in Grade 10 and depressive symptoms in Grades 9 and 11, and for whom residential address information was available. There was a significant indirect effect of past moves in middle school on depressive symptoms 1 year later through reduced neighborhood cohesion. However, the indirect effect was not significant in a propensity score‐matched sample. Results from the full sample of adolescents suggest that neighborhood cohesion may play a role in the experience of depressive symptoms following past moves in middle school. Different findings for the propensity score‐matched sample highlight the need for future studies of residential mobility to employ strategies to correct for possible selection bias.
Cycles of instability: Proximal and distal influences on residential instability among people with histories of homelessness in three Canadian cities
Authors: Czechowski Konrad , Sylvestre John , Gogosis Evie , Agha Ayda , Kerman Nick , Polillo Alexia , Palepu Anita , Hwang Stephen W. 
Published: March 2022

AbstractPeople with histories of homelessness often have difficulties obtaining and maintaining adequate housing. This qualitative study examined the residential transitions of people with histories of residential instability and homelessness to understand factors contributing to the instability they experience. Interviews were conducted with 64 participants about their housing transitions, in the final year of a 4‐year, prospective cohort study in three Canadian cities (Ottawa, Toronto, and Vancouver). Findings showed that participants pointed to both distal and proximal factors as affecting residential transitions, including interpersonal conflict, safety concerns, substance use, poverty, pests, and health. Many reported disconnection from their housing and a lack of improvement from one housing situation to the next, demonstrating how even when housed, instability persisted. Our study highlights the complexity associated with participants' often unplanned and abrupt residential transitions. The complex and distal issues that affect housing transitions require structural changes, in addition to individual‐based interventions focused on the proximal problems.
The early embryonic transcriptome of a Hawaiian Drosophila picture‐wing fly shows evidence of altered gene expression and novel gene evolution
Authors: Chenevert Madeline , Miller Bronwyn , Karkoutli Ahmad , Rusnak Anna , Lott Susan E. , Atallah Joel 
Published: March 2022

AbstractA massive adaptive radiation on the Hawaiian archipelago has produced approximately one‐quarter of the fly species in the family Drosophilidae. The Hawaiian Drosophila clade has long been recognized as a model system for the study of both the ecology of island endemics and the evolution of developmental mechanisms, but relatively few genomic and transcriptomic datasets are available for this group. We present here a differential expression analysis of the transcriptional profiles of two highly conserved embryonic stages in the Hawaiian picture‐wing fly Drosophila grimshawi. When we compared our results to previously published datasets across the family Drosophilidae, we identified cases of both gains and losses of gene representation in D. grimshawi, including an apparent delay in Hox gene activation. We also found a high expression of unannotated genes. Most transcripts of unannotated genes with open reading frames do not have identified homologs in non‐Hawaiian Drosophila species, although the vast majority have sequence matches in genomes of other Hawaiian picture‐wing flies. Some of these unannotated genes may have arisen from noncoding sequence in the ancestor of Hawaiian flies or during the evolution of the clade. Our results suggest that both the modified use of ancestral genes and the evolution of new ones may occur in rapid radiations.
Towards the first 90: impact of the national HIV self‐test program on case finding and factors associated with linkage to confirmatory diagnosis in Taiwan
Authors: Huang Yen‐Fang , Huang Yu‐Ching , Lo Yi‐Chun , Latkin Carl , Huang Hsun‐Yin , Lee Chia‐Chi , Pan Li‐Chern , Kuo Hsu‐Sung 
Published: March 2022

AbstractIntroductionBeing aware of one's HIV‐positive status can help reduce unprotected sex and promote early treatment seeking. Therefore, HIV self‐test (HIVST) programs may help control the HIV epidemic by case finding. The aims of this study were to determine the effect of HIVST programs on HIV case finding, time to confirmatory diagnosis and factors associated with linkage to confirmatory diagnosis in Taiwan.MethodsThe Centers for Disease Control in Taiwan initiated HIVST programs and imported 78,000 self‐test kits in 2017 and 2019. Clients paid 7 US dollars for a self‐test kit at facilities, vending machines or online. The programs set up an HIVST logistics management system; each kit had a unique barcode for monitoring the programs because purchases were anonymous. When clients provided their test results with photo barcodes online or at HIV/AIDS‐designated hospitals, they received full monetary reimbursement. We conducted a quasi‐experimental interrupted time‐series (ITS) analysis that covered a period of 60 months from 2015 to 2019. We enrolled a retrospective cohort of reported HIV cases with initial positive results from HIVST programs between March 2017 and July 2020.ResultsThe ITS analysis included data from 10,976 reported HIV cases from 2015 to 2019. The HIVST‐positive cohort included 386 reported HIV cases, of whom 99.7% were males and 97% were men who have sex with men (MSM); the median age was 28 years. The ITS analysis showed a positive slope change in the number of reported HIV cases immediately in the beginning implementation month (coefficient: 51.09 in 2017 and 3.62 in 2019), but there was a significant decrease over time. It was a negative slope change by 9.52 cases per month in 2017 and 5.56 cases per month in 2019. In the HIVST‐positive cohort, three of five individuals linked to HIV confirmatory diagnosis within 1 month after a positive self‐test result, and an early linkage to confirmatory diagnosis was associated with HIVST disclosure (adjusted OR = 6.5; 95% CI: 3.9–10.6).ConclusionsHIVST programs were associated with an increase in HIV case finding. Our findings suggest that countries with a high incidence of HIV among MSM populations should offer multichannel HIVST services.
South–South trade: An analysis of trade integration in the G‐77
Authors: Afonso Damares Lopes , Perobelli Fernando Salgueiro , de Andrade Bastos Suzana Quinet 
Published: March 2022

AbstractThis article investigates the economic impacts of greater trade integration in the Group of 77 (G‐77) through the GTAP model. The analyses are based on reductions in import tariffs on agricultural and industrial products, considering scenarios with and without the China participation. The economic impacts tend to strengthen production and trade in industrial sectors in already industrialised regions and agriculture in regions more dependent on this sector—pattern reinforced with China's presence. China's trade also leads to a drop in Gross Domestic Product (GDP) in some G‐77 countries, with these losses outweigh welfare gains mainly in some least developed countries.
Comparative characterization of SARS‐CoV‐2 variants of concern and mouse‐adapted strains in mice
Authors: Chen Qi , Huang Xing‐Yao , Liu Yu , Sun Meng‐Xu , Ji Bin , Zhou Chao , Chi Hang , Zhang Rong‐Rong , Luo Dan , Tian Ying , Li Xiao‐Feng , Zhao Hui , Qin Cheng‐Feng 
Published: March 2022

AbstractSARS‐CoV‐2 has evolved into a panel of variants of concern (VOCs) and constituted a sustained threat to global health. The wildtype (WT) SARS‐CoV‐2 isolates fail to infect mice, while the Beta variant, one of the VOCs, has acquired the capability to infect standard laboratory mice, raising a spreading risk of SARS‐CoV‐2 from humans to mice. However, the infectivity and pathogenicity of other VOCs in mice remain not fully understood. In this study, we systematically investigated the infectivity and pathogenicity of three VOCs, Alpha, Beta, and Delta, in mice in comparison with two well‐understood SARS‐CoV‐2 mouse‐adapted strains, MASCp6 and MASCp36, sharing key mutations in the receptor‐binding domain (RBD) with Alpha or Beta, respectively. Our results showed that the Beta variant had the strongest infectivity and pathogenicity among the three VOCs, while the Delta variant only caused limited replication and mild pathogenic changes in the mouse lung, which is much weaker than what the Alpha variant did. Meanwhile, Alpha showed comparable infectivity in lungs in comparison with MASCp6, and Beta only showed slightly lower infectivity in lungs when compared with MASCp36. These results indicated that all three VOCs have acquired the capability to infect mice, highlighting the ongoing spillover risk of SARS‐CoV‐2 from humans to mice during the continued evolution of SARS‐CoV‐2, and that the key amino acid mutations in the RBD of mouse‐adapted strains may be referenced as an early‐warning indicator for predicting the spillover risk of newly emerging SARS‐CoV‐2 variants.
Patients with cam‐type femoroacetabular impingement demonstrate increased change in bone‐to‐bone distance during walking: A dual fluoroscopy study
Authors: Lewis Cara L. , Uemura Keisuke , Atkins Penny R. , Lenz Amy L. , Fiorentino Niccolo M. , Aoki Stephen K. , Anderson Andrew E. 
Published: March 2022

AbstractCam‐type femoroacetabular impingement (FAI) syndrome is a painful, structural hip disorder. Herein, we investigated hip joint mechanics through in vivo, dynamic measurement of the bone‐to‐bone distance between the femoral head and acetabulum in patients with cam FAI syndrome and morphologically screened controls. We hypothesized that individuals with cam FAI syndrome would have larger changes in bone‐to‐bone distance compared to the control group, which we would interpret as altered joint mechanics as signified by greater movement of the femoral head as it articulates within the acetabulum. Seven patients with cam FAI syndrome and 11 asymptomatic individuals with typical morphology underwent dual fluoroscopy imaging during level and inclined walking (upward slope). The change in bone‐to‐bone distance between femoral and acetabular bone surfaces was evaluated for five anatomical regions of the acetabulum at each timepoint of gait. Linear regression analysis of the bone‐to‐bone distance considered two within‐subject factors (activity and region) and one between‐subjects factor (group). Across activities, the change in minimum bone‐to‐bone distance was 1.38–2.54 mm for the cam FAI group and 1.16–1.84 mm for controls. In all regions except the anterior–superior region, the change in bone‐to‐bone distance was larger in the cam group than the control group (p ≤ 0.024). An effect of activity was detected only in the posterior–superior region where larger changes were noted during level walking than incline walking. Statement of clinical significance: Patients with cam FAI syndrome exhibit altered hip joint mechanics during the low‐demand activity of walking; these alterations could affect load transmission, and contribute to pain, tissue damage, and osteoarthritis.
Methodology matters when estimating deer abundance: a global systematic review and recommendations for improvements
Authors: Forsyth David M. , Comte Sebastien , Davis Naomi E. , Bengsen Andrew J. , Côté Steeve D. , Hewitt David G. , Morellet Nicolas , Mysterud Atle 
Published: March 2022

AbstractDeer (Cervidae) are key components of many ecosystems and estimating deer abundance or density is important to understanding these roles. Many field methods have been used to estimate deer abundance and density, but the factors determining where, when, and why a method was used, and its usefulness, have not been investigated. We systematically reviewed journal articles published during 2004–2018 to evaluate spatio‐temporal trends in study objectives, methodologies, and deer abundance and density estimates, and determine how they varied with biophysical and anthropogenic attributes. We also reviewed the precision and bias of deer abundance estimation methods. We found 3,870 deer abundance and density estimates. Most estimates (58%) were for white‐tailed deer (Odocoileus virginianus), red deer (Cervus elaphus), and roe deer (Capreolus capreolus). The 6 key methods used to estimate abundance and density were pedestrian sign (track or fecal) counts, pedestrian direct counts, vehicular direct counts, aerial direct counts, motion‐sensitive cameras, and harvest data. There were regional differences in the use of these methods, but a general pattern was a temporal shift from using harvest data, pedestrian direct counts, and aerial direct counts to using pedestrian sign counts and motion‐sensitive cameras. Only 32% of estimates were accompanied by a measure of precision. The most precise estimates were from vehicular spotlight counts and from capture–recapture analysis of images from motion‐sensitive cameras. For aerial direct counts, capture–recapture methods provided the most precise estimates. Bias was robustly assessed in only 16 studies. Most abundance estimates were negatively biased, but capture–recapture methods were the least biased. The usefulness of deer abundance and density estimates would be substantially improved by 1) reporting key methodological details, 2) robustly assessing bias, 3) reporting the precision of estimates, 4) using methods that increase and estimate detection probability, and 5) staying up to date on new methods. The automation of image analysis using machine learning should increase the accuracy and precision of abundance estimates from direct aerial counts (visible and thermal infrared, including from unmanned aerial vehicles [drones]) and motion‐sensitive cameras, and substantially reduce the time and cost burdens of manual image analysis.