bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strengthening Interpersonal Relationships in Maternal and Child Health Care in Rural Tanzania: Protocol for a Human-Centered Design Intervention
Authors: Isangula Kahabi , Shumba Constance , Pallangyo Eunice S , Mbekenga Columba , Ndirangu-Mugo Eunice 
Published: May 2022

Background
Evidence indicates that clients’ dissatisfaction with providers’ competencies within maternal and child health (MCH) continues to impact trust in formal health care systems, service uptake, continuity with care, and MCH outcomes. A major problem with existing interventions is the failure to address all the complexities of provider-client relationships necessitating targeted, contextualized, innovative solutions that place providers and clients at the forefront as agents of change in optimizing intervention design and implementation. To improve the provider-client relationship, the Aga Khan University is piloting a human-centered design (HCD) intervention where MCH nurses and clients are invited to partner with researchers in the intervention design and evaluation process.

Objective
The objective of this research is to co-design an intervention package (prototype) for improving nurse-client relationships in the rural Shinyanga region of Tanzania using a series of iterative HCD steps, involving key stakeholders to tailor solutions for complex problems impacting provider-client interactions in MCH care.

Methods
The following 5-step HCD approach will be implemented: (1) community-driven discovery through qualitative descriptive research methods using focus group discussions and key informant interviews; (2) co-design of an intervention package through consultative ideation and cocreation meetings with nurses, clients, and other stakeholders; (3) prototype validation through qualitative insight gathering using focus group discussions; (4) refinement and adaptation meeting; and (5) documentation and sharing of lessons learned before the final prototype is tested and validated in a broader community.

Results
A prototype characterized by a package of interventions for improving nurse-client relationships in MCH care in rural contexts is expected to be developed from the co-design process.

Conclusions
An HCD approach provides a novel entry point for strengthening provider-client relationships, where clients are invited to partner with providers in the design of acceptable and feasible interventions.

International Registered Report Identifier (IRRID)
DERR1-10.2196/37947
Effect of FN1 mutation on outcomes of fibronectin glomerulopathy in a systematic review and meta-analysis
Authors: Shamekhi Fateme 
Published: May 2022

Background. Fibronectin glomerulopathy is an inherited kidney disease that is characterized with extensive depositions of fibronectin in mesangium and subendothelial space. The aim of study is to assess effect of fibronectin gene on decreased renal function and likeliness of recurrence of the disease after kidney transplantation. Materials and methods. In retrospective descriptive studies, fifty-seven patients with fibronectin glomerulopathy were enrolled in this research. Relative risk and Odds ratio for assessing effect measures of risk factor on outcomes of disease were used. Results. Of fifty-seven patients with fibronectin glomerulopathy, thirty-six patients (36/57, 63.1 %) were male and twenty-one patients were female (21/57, 36.8 %). Relative risk and Odds ratio of end-stage kidney disease (ESKD) in nephrotic-range proteinuria versus non-nephrotic range proteinuria were assessed 1.33 and 1.39, respectively. Relative risk and Odds ratio of end-stage kidney disease with kidney replacement therapy (KRT) in patients with positive FN1 gene (as risk or contributing factor) versus patients with negative FN1 gene was assessed 0.66 and 0.50, respectively. Risk of recurrence after kidney transplant with nephrotic-range proteinuria was assessed 0.83 (95% confidence interval of 0.1213 to 5.7244) and odds ratio of recurrence after kidney transplant with nephrotic proteinuria versus non-nephrotic range proteinuria was assessed 0.75 (95% confidence interval of 0.03757 to 14.9733) in the current research. Conclusions. Relative risk and odds ratio of end-stage kidney disease in nephrotic-range proteinuria versus non-nephrotic range proteinuria were assessed 1.33 and 1.39, respectively. Therefore, it appears risk of fibronectin gene 1 on end-stage kidney disease with kidney replacement therapy be low.
Expression of plasmid-mediated resistance genes ESBLs and PMQR among uropathogens, isolated from non-dialysis CKD patients with pyelonephritis
Authors: Chub O.І. , Teslenko S.V. , Chub O.V. 
Published: May 2022

Urinary tract infections (UTIs) are thought to be the most common group of bacterial infections, worldwide. It is estimated that the proportion of UTIs remains at a high level reaching 150 million episodes per year worldwide and accounting for $6 billion in health care expenditures. In USA more than 100,000 hospital admissions per year are the UTIs patients, among them the patients with pyelonephritis are the most frequent. For the US outpatients, approximately 15 % of antibiotics used are prescribed for UTIs. However, recent studies in Europe and the United States have demonstrated a steady increase in the rate of uropathogen resistance to commonly prescribed antibiotics, and this obviously will lead to a reduction in therapeutic possibilities of UTI. CDC has estimated that more thаn 2 million infections and 23,000 deaths are due to antibiotic resistance each year. By 2050, it is estimated, that antibiotic resistance will cause 10 million deaths every year. Infection is an importаnt cause of mоrbidity and mоrtality amоng patients with kidney failurе and is the sеcond lеading causе of death following CVD. At the EU/EEA level, more than half (54 %) of the E.coli isolates reported to EARS-Net for 2020 were resistant to at least one of the antimicrobial groups under regular surveillance, i.e. aminopenicillins, fluoroquinolones, third-generation cephalosporins, aminoglycosides and carbapenems. A majority (87.4 %) of the third-generation cephalosporin-resistant E.coli isolates from 2020 were extended-spectrum beta-lactamase (ESBL) positive. Use of broad-spectrum antimicrobials is a known risk factor for colonization and spread of resistant Enterobacteriaceae, including E.coli. The high levels of ESBLs and increasing resistance to key antimicrobial groups might also lead to an increased consumption of carbapenems, which in turn can increase the selection pressure and facilitated the spread of carbapenem-resistant Enterobacteriaceae. The article presents data on the antibacterial susceptibility of isolated uropathogens, and their association with the presence or absence of plasmid-mediated resistance genes ESBLs and PMQR.
Mesangial proliferative glomerulonephritis with monoclonal immunoglobulin deposits: why nephrobiopsy is crucial
Authors: Chub O.I. , Dyadyk O.O. , Ivanov D.D. 
Published: May 2022

Proliferative glomerulonephritis (GN) with monoclonal immunoglobulin deposits (PGNMIDs) is a recently described entity among the spectrum of monoclonal gammopathy of renal significance (MGRS). The disease is renal limited and manifests in chronic glomerular disease, altered renal function and albuminuria, sometimes in the nephrotic range. Acute nephritic syndrome is rare. Until recently, in the absence of criteria for symptomatic haematological disease, patients with monoclonal Ig-related nephropathies often experienced difficulties in getting appropriate chemotherapy. Noticeable progress in management was achieved with the introduction of the concept of monoclonal gammopathy of renal significance, which distinguishes the situation of nephropathies induced by dangerous small B-cell clones from that of monoclonal gammopathy of undetermined significance (MGUS) that does not feature any end-organ damage. Monoclonal gammapathy of renal significance is not an independent kidney disease, not “chronic glomerulonephritis”, but a condition in which kidney damage is secondary to clonal B-cell proliferation. In other words, MGRS is a precancerous disease combined with chronic kidney disease that requires immediate treatment. Renal prognosis is poor, with progression to end stage renal disease in 25 % of patients within 30 months and frequent early recurrence on the renal allograft. However, recent studies indicate that clone-targeted chemotherapy may significantly improve renal outcomes, opening future perspectives for the management of this rare disease.
Hardiness, Dukungan Sosial, dan Penyesuaian Diri Guru Tingkat Sekolah Dasar di Masa Pandemi Covid-19
Authors: Purifiedriyaningrum Immatulfathina , Saptandari Edilburga Wulan 
Published: May 2022

Guru sebagai salah satu aktor utama dalam pendidikan perlu memiliki kemampuan penyesuaian diri yang baik agar mampu merespon ketidakpastian, perubahan, dan kebaruan secara efektif. Riset ini bertujuan untuk mengetahui peran hardiness dan dukungan sosial pada penyesuaian diri guru dalam konteks pembelajaran di masa pandemi Covid-19 di tingkat sekolah dasar. Sebanyak 198 guru di tingkat sekolah dasar terlibat dalam studi survei kuantitatif ini. Penelitian ini menggunakan convenience sampling sebagai teknik sampling dan menggunakan analisis regresi berganda untuk menganalisis data yang diperoleh. Tiga instrumen yang digunakan dalam penelitian ini adalah skala hardiness, skala penyesuaian diri, dan skala dukungan sosial. Hasil analisis membuktikan bahwa secara simultan hardiness dan dukungan sosial berperan pada penyesuaian diri guru dengan sumbangan efektif sebesar 47,8% (F = 89,21; p < 0,01). Hasil tersebut dapat menjadi salah satu dasar bagi pengambil kebijakan di dunia pendidikan guna meningkatkan kemampuan guru dalam menyesuaikan diri menghadapi perubahan yang terus terjadi.
A avaliação e registo da dor no serviço de urgência: um estudo transversal
Authors: Figueira Alexandra Isabel Rebelo , Amaral Guida Maria Marques da Silva , Carmo Tânia Isabel Gomes do 
Published: May 2022

Introdução: A dor constitui-se como o principal motivo de procura de cuidados de saúde no serviço de urgência. Os enfermeiros têm um papel essencial na promoção e intervenção no controlo da dor dado serem profissionais com uma relação privilegiada com as pessoas. Objetivo: Descrever como foi avaliada e registada a dor na área de ambulatório de um serviço de urgência geral pela equipa de enfermagem. Metodologia: Estudo quantitativo, descritivo e transversal. Foram analisados os registos de avaliação da dor de 105 pessoas. Procedeu-se à análise dos dados utilizando estatística descritiva. Resultados: A dor foi avaliada em 53 episódios (50,48 %). A Escala de Avaliação Numérica foi o instrumento mais utilizado (43,81 %). As características da dor foram descritas em 39,05 % dos episódios. Em 1,90 % dos episódios houve registo de reavaliação da dor após implementação de medidas farmacológicas. Conclusão: A avaliação da dor foi subnotificada nas diferentes dimensões descritas no estudo. Neste sentido, torna-se essencial a definição de estratégias para a formação e treino dos enfermeiros sobre avaliação da dor.
Flakes Studi Karakteristik Flakes Tepung Pisang Kepok (Musa paradisiaca var. Formatipyca) Dengan Subtitusi Tepung Sagu
Authors: Hulu Adminarwati , Handoko Yoga Aji 
Published: May 2022

Flakes merupakan produk makanan kering, berkadar air rendah, berbentuk lembaran tipis yang banyak disukai oleh masyarakat karena waktu yang singkat serta cepat dalam penyajiannya. Pada umumya, tepung jagung, tepung beras, serta tepung gandum merupakan bahan dasar dalam pembuatan flakes. Penggunaan jenis tepung lain juga telah banyak digunakan dalam pengolahan flakes salah satunya tepung pisang kepok, namun penggunaan tepung pisang kepok memiliki kelemahan terkait tingkat kerenyahan rendah. Tingkat kerenyahan pada produk dipengaruhi oleh kandungan amilosa bahan. Substitusi tepung sagu yang memiliki kadar amilosa relatif tinggi diharapkan dapat memperbaiki tekstur dan karakteristik produk flakes berbasis tepung pisang kepok. Melalui permasalahan ini, maka diperlukan substitusi bahan tepung sagu untuk memperbaiki karakteristik flakes. Tujuan penilitian menganalisis pengaruh perbandingan yang tepat tepung pisang kepok dengan tepung sagu dan menentukan perbandingan yang terbaik terhadap sifat fisikokimia dan organoleptik flakes. Pelaksanaan penelitian menggunakan Rancangan Acak Kelompok (RAK), terdiri dari 1 faktor yaitu subtitusi tepung sagu terhadap tepung pisang kepok (100%), (60%:40%), (70%:30%) dan (80%:20%). Data dianalisis dengan sidik ragam (ANOVA) serta uji lanjut menggunakan DMRT selang kepercayaan 5%. Berdasarkan hasil analisis sifat fisikokimia perlakuan 60% tepung pisang: 40% tepung sagu menunjukkan hasil yang terbaik, dengan kadar air (1,461%), kadar abu (3,8400), kadar lemak (0,151667), kadar protein (1,20000), kadar karbohidrat (78,798), daya serap (92,023), dan serat kasar (3,9000). Pengujian organoleptik juga menunjukan bahwa perlakuan 60% tepung pisang : 40% tepung sagu merupakan perlakuan terbaik, dengan indeks penilaian yang optimal antara lain aroma (70% suka), warna (64% suka), rasa (67,33% suka), dan tekstur (80,67% sangat suka), sedangkan untuk perlakuan lainnya penilaian panelis terhadap produk rata-rata pada kategori “suka”.
Partisipasi dan Peran Perempuan Sebagai Suatu Inklusifitas pada Usahatani Kakao
Authors: H.M Rahmaniah , Darma Rahim , Nasaruddin Nasaruddin , Arsyad Muhammad 
Published: May 2022

Perempuan petani berperan penting baik dalam rumah tangga, maupun di sektor produksi. Perempuan terlibat pada hampir semua pekerjaan pada usahatani kakao. Kemiskinan dan pengangguran yang meningkat mendorong perempuan aktif bekerja pada sektor ekonomi untuk mendapatkan tambahan pendapatan rumahtangga. Tujuan penelitian adalah untuk menganalisis peran dan tingkat partisipasi perempuan sebagai pengelola, tenaga kerja, kegiatan penyuluhan dan dalam pengambilan keputusan pada usahatani kakao. Metode penelitian adalah survei dengan 250 petani yang dipilih secara acak sederhana. Analisis data adalah deskripsi dan disajikan dalam bentuk grafik. Hasil penelitian menunjukkan bahwa peran dan tingkat partisipasi perempuan sebagai pengelola, tenaga kerja, partisipasi dalam kegiatan penyuluhan dan pengambilan keputusan pada usahatani kakao adalah kategori tinggi pada kegiatan pembibitan, panen, pasca panen, pemasaran; kategori sedang pada pengolahan lahan, pemupukan; dan kategori rendah pada kegiatan penanaman, penyambungan, pemangkasan, pengendalian hama dan penyakit. Keterlibatan perempuan dan sinergitas dengan suami pada usahatani kakao merupakan salah satu bentuk inklusifitas yang dapat mendorong peningkatan pendapatan, keberlajutan pembangunan masyarakat tani, dan pelaksanaan program pembangunan lainnya.
Pengembangan Hutan Tanaman Rakyat di Wilyah KPHP Model Dampelas Tinombo Desa Karya Mukti Kecamatan Dampelas Kabupaten Donggala
Authors: Rachman Imran 
Published: May 2022

Penentuan pengelolaan hutan yang tepat di lakukan untuk mewujudkan kondisi hutan yang lestari dan bermanfaat secara optimum bagi masyarakat baik secara langsung maupun tidak langsung. Undang-undang 41 tahun 1999 tentang kehutanan mengamanatkan pembentukan wilayah pengelolaan hutan di tingkat propinsi, kabupaten/kota, dan unit pengelolaan yakni berupa unit-unit kesatuan pengelolaan hutan (KPH) terkecil sesuai fungsi pokok dan peruntukannya. Penyelenggaraan pengelolaan hutan dalam KPH menjadi perwujudan untuk melaksanakan manajemen hutan yang meliputi kegiatan tata hutan, upaya pemerintah dalam menegaskan UU tersebut di atas adalah di terbitkannya PP 6/2007 jo PP 3 Tahun 2008 tentang tata hutan, Penyusunan Rencana Pengelolaan Hutan, serta pemanfaatan hutan yang menjelaskan KPH meliputi KPH Konservasi (KPHK), KPH Lindung (KPHL), KPH Produksi (KPHP). Penelitian ini dilaksanakan di lokasi Hutan Produksi Desa Karya Mukti Kec.Dampelas Kabupaten Donggala. Waktu pelaksanaan mulai bulan oktober sampai dengan bulan Desember 2017. Sumber data yang diperoleh dalam penelitian ini terdiri atas data sekunder dan primer. Metode yang digunakan untuk mengumpulkan data metode observasi dan wawancara, yaitu dilakukan pengamatan secara langsung terhadap objek yang akan diteliti dan tanya jawab dengan menggunakan panduan pertanyaan dalam bentuk kuisioner. Kondisi biofisik lokasi sangat tepat untuk kegiatan pemanfaatan hasil hutan bukan kayu hutan tanaman dengan jenis tanaman karet karena dapat memberi manfaat ekologi untuk perbaikan lingkungan dan mengoptimalkan kembali fungsi hutan. Pengembangan HTR dalam bentuk pemberdayaan masyarakat di Desa Karya Mukti sangat sesuai dengan kondisi sosial ekonomi masyarakat karena dapat memberi manfaat ekonomi untuk menambah pendapatan masyarakat.
Pengujian Kualitas Benih Kedelai pada Pemberian Inokulasi Rhizobium Sp dengan Berbagai Tingkat Ketersediaan Air
Authors: Yusran Yusran , Hawalina Hawalina , Hastuti Hastuti , Humaerah N. , Somba Bunga Elim , I I. K. Utami. 
Published: May 2022

Penelitian yang bertujuan untuk mengkaji pengaruh inokulasi Rhizobium Sp. pada kedelai dalam berbagai kondisi ketersediaan air terhadap kualitas benih yang dihasilkan, telah dilaksanakan di Green house Laboratorium Teknologi Benih Faperta Untad pada bulan April sampai November 2021 dengan percobaan pot menggunakan rancangan acak lengkap (RAL). Faktor pertama adalah pemberian inokulasi Rhizobium sp. yang terdiri atas 2 macam yaitu: Inokulum Rhizobium 10 g/kg benih, Inokulum Rhizobium 15 g/kg benih, Faktor kedua adalah tingkat ketersediaan air yang meliputi: ketersediaan air 100% (kapasitas lapangan), ketersediaan air 80%, ketersediaan air 60%, ketersediaan air 40%.
Hasil penelitian menunjukkan bahwa pemberian inokulasi Rhizobium sp 15 g/kg benih meningkatkan pertumbuhan dan hasil kedelai. Hal tersebut berdampak pada pertumbuhan kedelai mampu meningkatkan secara signifikan jumlah bintil akar, berat kering bintil akar, tinggi tanaman, diameter batang, kehijauan daun dan berat 100 biji. Ketersediaan air 100% juga memberikan pengaruh yang signifikan terhadap jumlah bintil akar, berat kering bintil akar, tinggi tanaman, diameter batang, jumlah cabang produktif, kehijauan daun, jumlah biji per tanaman, berat biji per tanaman, berat 100 biji, dan proporsi ukuran biji. Terdapat interaksi antara pemberian inokulasi Rhizobium sp dan tingkat ketersediaan air terhadap tinggi tanaman dan berat 100 biji.
Novel subgroups of type 2 diabetes display different epigenetic patterns which associate with future diabetic complications
Authors: Schrader Silja , Perfilyev Alexander , Ahlqvist Emma , Groop Leif , Vaag Allan , Martinell Mats , García-Calzón Sonia , Ling Charlotte 
Published: May 2022

<p><strong>Objective:</strong> Type 2 diabetes (T2D) was recently reclassified into Severe Insulin Deficient Diabetes (SIDD), Severe Insulin Resistant Diabetes (SIRD), Mild Obesity-related Diabetes (MOD), and Mild Age-Related Diabetes (MARD), which have different risk of complications. We explored whether DNA methylation differs between these subgroups and if subgroup-unique methylation risk scores (MRSs) predict diabetic complications. </p>
<p><strong>Methods:</strong> Genome-wide DNA methylation was analysed in blood from newly diagnosed T2D subjects in discovery and replication cohorts. Subgroup-unique MRSs were built including top subgroup-unique DNA methylation sites. Regression models examined whether MRSs associated with subgroups and future complications. </p>
<p><strong>Results:</strong> We found epigenetic differences between the T2D subgroups. Subgroup-unique MRSs were significantly different in those patients allocated to each respective subgroup compared to the combined group of all other subgroups. These associations were validated in an independent replication cohort, showing that subgroup-unique MRSs associate with individual subgroups (OR 1.6-6.1 per 1SD increase, p<0.01). Subgroup-unique MRSs were also associated with future complications. Higher MOD-MRS was associated with lower risk of cardiovascular (HR=0.65, p=0.001) and renal (HR=0.50, p<0.001) disease, whereas higher SIRD-MRS and MARD-MRS were associated with increased risk of these complications (HR 1.4-1.9 per 1SD increase, p<0.01). 39 of 95 methylation sites included in subgroup-unique MRSs were annotated to genes previously linked to diabetes-related traits, including <em>TXNIP </em>and <em>ELOVL2</em>. Methylation in blood of 18 subgroup-unique sites mirror epigenetic patterns in tissues relevant for T2D, muscle and adipose tissue. </p>
<p><strong>Conclusions:</strong> We identified differential epigenetic patterns between T2D subgroups, which associated with future diabetic complications. These data support a reclassification of diabetes and the need for precision medicine in T2D subgroups. </p>
ANALISIS KESALAHAN DALAM MENGERJAKAN SOAL MATEMATIKA PADA POKOK BAHASAN POLA BILANGAN SMPN 1 BLAHBATUH TAHUN AJARAN 2020/2021
Authors: Noviantari Putu Suarniti 
Published: May 2022

ABSTRAKPenelitian ini adalah penelitian deskriptif dengan metode kualitatif. Penelitian ini bertujuan untuk mengetahui jenis-jenis kesalahan siswa dalam mengerjakan soal pemecahan masalah dengan Prosedur Newman dan penyebab kesalahannya. Subjek penelitian ini adalah siswa kelas VIII D SMPN 1 Blahbatuh yang kemudian dikelompokkan menjadi 3 kelompok yaitu kelompok tinggi, sedang, dan rendah yang diambil 2 siswa dari masing-masing kelompok sehingga jumlah subjek penelitian menjadi 6 siswa. Data dalam penelitian ini adalah soal tes pemecahan masalah materi pola bilangan dan wawancara. Teknik analisis datanya menggunakan reduksi data, penyajian data, penarikan kesimpulan, dan keabsahan data (triangulasi).Hasil penelitian menunjukkan bahwa dari ketiga kelompok, jenis kesalahan yang paling sering dilakukan adalah 1) membaca masalah, 2) memahami masalah, 3) transformasi, dan 4) penulisan jawaban. Kesalahan 1 sampai 4 sering dilakukan oleh kelompok rendah, kesalahan 2 sampai 4 sering dilakukan oleh kelompok sedang, dan kesalahan 3 dan 4 sering dilakukan oleh kelompok tinggi. Penyebab kesalahan yang sering dilakukan ketiga kelompok adalah : tidak bisa menyusun makna kata yang dipikirkan kedalam bentuk struktur gramatikal, tidak memahami makna kata yang diminta, kurang teliti, terlalu tergesa-gesa dalam mengerjakan soal, dan tidak bisa mengatur waktu dengan baik.Kata kunci : Pembelajaran Matematika;Kesalahan Siswa;Prosedur Newman ABSTRACTThis research is a descriptive study with qualitative methods. This study aims to determine the types of student errors in solving problems with the Newman procedure and the causes of the errors. The subjects of this study were students of class VIII D of SMPN 1 Blahbatuh who were then grouped into 3 groups, namely the high, medium, and low groups which were taken by 2 students from each group so that the number of research subjects became 6 students. The data in this study were the problem solving questions of the number pattern material and interviews. The data analysis technique used data reduction, data presentation, drawing conclusions, and data validity (triangulation). The results showed that of the three groups, the most frequent types of errors were 1) reading the problem, 2) understanding the problem, 3) transformation, and 4) writing answers. Mistakes 1 to 4 are often done by the low group, errors 2 to 4 are often done by the moderate group, and errors 3 and 4 are often done by the high group. The causes of mistakes that are often made by the three groups are: not being able to compile the meaning of the thought thought into a grammatical structure, not understanding the meaning of the word requested, not being careful, being too hasty in working on the problem, and not being able to manage the time well. Keywords : Mathematics learning;Student error;Newman procedure