bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anxiety and depression in Charcot-Marie-Tooth disease: data from the Italian CMT national registry
Authors: Bellofatto Marta , Bertini Alessandro , Tramacere Irene , Manganelli Fiore , Fabrizi Gian Maria , Schenone Angelo , Santoro Lucio , Cavallaro Tiziana , Grandis Marina , Previtali Stefano C. , Allegri Isabella , Padua Luca , Pazzaglia Costanza , Calabrese Daniela , Saveri Paola , Quattrone Aldo , Valentino Paola , Tozza Stefano , Gentile Luca , Russo Massimo , Mazzeo Anna , Vita Giuseppe , Piacentini Sylvie , Pisciotta Chiara , Pareyson Davide ,   for the Italian CMT Network, Schirinzi Giulia , Montesano Maria , Nuzzo Sara , Oggiano Francesca , Gemelli Chiara , Scarlato Marina , Spina Emanuele , Longo Maria 
Published: September 2022

Abstract
Background
There is little information about neuropsychiatric comorbidities in Charcot-Marie-Tooth disease (CMT). We assessed frequency of anxiety, depression, and general distress in CMT.

Methods
We administered online the Hospital Anxiety-Depression Scale (HADS) to CMT patients of the Italian registry and controls. HADS-A and HADS-D scores ≥ 11 defined the presence of anxiety/depression and HADS total score (HADS-T) ≥ 22 of general distress. We analysed correlation with disease severity and clinical characteristics, use of anxiolytics/antidepressants and analgesic/anti-inflammatory drugs.

Results
We collected data from 252 CMT patients (137 females) and 56 controls. CMT patient scores for anxiety (mean ± standard deviation, 6.7 ± 4.8), depression (4.5 ± 4.0), and general distress (11.5 ± 8.1) did not differ from controls and the Italian population. However, compared to controls, the percentages of subjects with depression (10% vs 2%) and general distress (14% vs 4%) were significantly higher in CMT patients. We found no association between HADS scores and disease duration or CMT type. Patients with general distress showed more severe disease and higher rate of positive sensory symptoms. Depressed patients also had more severe disease. Nineteen percent of CMT patients took antidepressants/anxiolytics (12% daily) and 70% analgesic/anti-inflammatory drugs. Patients with anxiety, depression, and distress reported higher consumption of anxiolytics/antidepressants. About 50% of patients with depression and/or general distress did not receive any specific pharmacological treatment.

Conclusions
An appreciable proportion of CMT patients shows general distress and depression. Both correlated with disease severity and consumption of antidepressants/anxiolytics, suggesting that the disease itself is contributing to general distress and depression.
Point process statistics improves particle size analysis
Authors: Stoyan Dietrich , Unland Georg 
Published: September 2022

Abstract
This paper re-considers the foundations of particle size statistics. While traditional particle size statistics consider their data as samples of random variables and use methods of classical mathematical statistics, here a particle sample is treated as a point process sample, and a suitable form of statistics is recommended. The whole sequence of ordered particle sizes is considered as a random variable in a suitable sample space. Instead of distribution functions, point process intensity functions are used. The application of point process data analysis is demonstrated for samples of fragments from single-particle crushing of glass balls. Three cases of data handling with point processes are presented: statistics for oversize particles, pooling of independent particle samples and pooling of piecewise particle data. Finally, the problem of goodness-of-fit testing for particle samples is briefly discussed. The point process approach turns out to be an extension of the classical approach, is simpler and more elegant, but retains all valuable traditional ideas. It is particularly strong in the analysis of oversize particles.

Graphical abstract
Erneuerbare Energien effizient und wirksam fördern
Authors:   Arbeitsgruppe „Energiesysteme der Zukunft“, Haucap Justus , Kühling Jürgen , Amin Munib , Brunekreeft Gert , Fouquet Dörte , Grimm Veronika , Gundel Jörg , Kment Martin , Ketter Wolfgang , Kreusel Jochen , Kreuter-Kirchhof Charlotte , Liebensteiner Mario , Moser Albert , Ott Marion , Rehtanz Christian , Wetzel Heike , Meinhof Jonathan , Wagner Marlene , Borgmann Miriam , Stephanos Cyril 
Published: September 2022

ZusammenfassungDas Jahr 2021 hat in Deutschland neuen Schwung in die Bemühungen zum Klimaschutz gebracht. Die Novelle des Klimaschutzgesetzes schreibt eine Reduktion der Treibhausgasemissionen um 65 % bis zum Jahr 2030 gegenüber 1990 fest. Maßgeblich dazu beitragen soll ein massiver Ausbau der Stromerzeugung aus erneuerbaren Energien. Nach Verschärfung der Klimaschutzmaßnahmen stellt sich die Frage, ob das bisherige Strommarktdesign und die damit einhergehenden Vergütungsregeln für die Stromerzeugung auch bei einem von erneuerbaren Energien dominierten Strommarkt weiterhin geeignet sind, um die im Energiewirtschaftsgesetz festgeschriebenen Ziele der Versorgungssicherheit und Preisgünstigkeit bestmöglich zu erreichen.
Loneliness among very old people with and without dementia: prevalence and associated factors in a representative sample
Authors: Lampinen Josefine , Conradsson Mia , Nyqvist Fredrica , Olofsson Birgitta , Gustafson Yngve , Nilsson Ingeborg , Littbrand Håkan 
Published: September 2022

AbstractLoneliness and dementia are common among very old (aged ≥ 80 years) people, but whether the prevalence of loneliness differs between very old people with and without dementia is unknown and few studies have investigated associated factors. The aims of the present study were to compare the prevalence of loneliness between people with and without dementia in a representative sample of very old people, and to investigate factors associated with loneliness in the two groups separately. This population-based study was conducted with data on 1176 people aged 85, 90, and ≥ 95 years (mean age 89.0 ± 4.47 years) from the Umeå 85 + /Gerontological Regional Database study conducted in northern Sweden, during year 2000–2017. Structured interviews and assessments were conducted during home visits. Loneliness was assessed using the question “Do you ever feel lonely?.” Multivariable logistic regression analysis was conducted to identify factors associated with loneliness in participants with and without dementia. The prevalence of loneliness did not differ between people with and without dementia (50.9% and 46.0%, respectively; p =  0.13). Seven and 24 of 35 variables were univariately associated with the experience of loneliness in participants with and without dementia, respectively. In the final models, living alone and having depressive symptoms were associated with the experience of loneliness in both study groups. In participants without dementia, living in a nursing home was associated with the experience of less loneliness. These findings contribute with important knowledge when developing strategies to reduce loneliness in this growing age group.
Dense pulses formed from fissioning internal waves
Authors: Hartharn-Evans Samuel G. , Stastna Marek , Carr Magda 
Published: September 2022

AbstractCold pulses generated by the fission of internal solitary waves over gentle slopes are an important source of nutrients and relief from excess heat to benthic ecosystems. This numerical study investigates the effect of stratification form on pulses produced by fission of internal solitary waves propagating over a smooth, gentle, linear topographic slope in 2D simulations. Three stratification types are investigated, namely (i) thin tanh (homogeneous upper and lower layers separated by a thin pycnocline), (ii) surface stratification (linearly stratified layer overlaying a homogeneous lower layer) and (iii) broad tanh (continuous density gradient throughout the water column). Incident wave amplitude was varied. In the thin tanh stratification, good agreement is seen with past studies, whilst the dynamics observed in the surface stratification are very similar to those in the thin tanh stratification. However, in the broad tanh stratification, due to the different form of incident waves, the fission dynamics differ, but produce pulses similar in form to those produced by fission in the other stratifications. Pulse amplitude, wavelength and propagation velocity are found to strongly depend on incident wave amplitude, and each degenerate linearly as the pulse propagates upslope.
Implementation of European Drone Regulations - Status Quo and Assessment
Authors: Janke Christian , de Haag Maarten Uijt 
Published: September 2022

AbstractThe fast evolution of drone technology as well as the ubiquitous adoption from private and commercial users lead to the necessity to introduce new regulations covering the operations of Unmanned Aircraft Systems (UAS) in European Member states. The regulations implemented rules for multiple scenarios of normal and complex UAS operations as well as the collection of registration data from remote pilots and Operators. This research project tried for the first time to determine the status quo of the adoption of the novel EASA regulations of drones within the European members states. Data from National Aviation Authorities has been collected, accumulated, and analyzed towards qualitative and quantitative features.
Synthesis, Ligating Properties, Thermal Behavior, Computational and Biological Studies of Some Azo-transition Metal Complexes
Authors: Masoud Mamdouh S. , Hemdan Sokaina S. , Elsamra Rehab M. I. 
Published: September 2022

AbstractSynthesis of new Fe(III), Co(II), Ni(II), and Cu(II) complexes of two azo ligands; 1-(phenyldiazenyl) naphthalene-2-ol (sudan orange R, HL1), and sodium 2-hydroxy-5-[(E)-(4-nitrophenyl) diazenyl]benzoate (alizarin yellow GG, HL2) have been reported. Stoichiometries of 1:2 and 1:3 (M:L) of the synthesized complexes were approved by total-reflection X-ray fluorescence technique (TXRF) and by elemental analyses. The geometry of complexes (octahedral and square planar) was typified by various spectroscopic, thermal, and magnetic techniques. The ESR spectroscopy showed that Cu(II) complexes are of different isotropic and rhombic symmetries with the existence of Cu–Cu ions interaction. TGA, DTA, and DSC analyses supported the multi-stage thermal decomposition mechanisms, where the thermal breakdown is ended by the formation of metal oxide in most cases. Moreover, chemical reactivity modeling using the density functional theory (DFT) method with the B3LYP/6–31 basis set, showed that metal complexes are more biologically active than their precursor ligands. The calculated lipophilicity character for metal complexes is in the range of 33.8–37.5 eV. Docking results revealed high scoring energy for [Fe(HL2)3].H2O complex and moderate inhibition strength of [Cu(L1)2].H2O complex versus 1bqb, 3t88, and 4esw proteins. Ultimately, the extent of biological effectiveness was endorsed experimentally against four microbial strains. The results are guidelines for toxicological investigations.
Graphical Abstract
Limited efficacy of temozolomide alone for astrocytoma, IDH-mutant, CNS WHO grades 2 or 3
Authors: Weller Jonathan , Katzendobler Sophie , Blobner Jens , Thiele Frederic , Becker Hannes , Quach Stefanie , Egensperger Rupert , Niyazi Maximilian , Suchorska Bogdana , Thon Niklas , Weller Michael , Tonn Joerg-Christian 
Published: September 2022

Abstract
Purpose
The role of temozolomide chemotherapy alone in isocitrate dehydrogenase (IDH)-mutant astrocytomas has not been conclusively determined. Radiotherapy might be superior to temozolomide. Recent studies have linked temozolomide with induction of hypermutation and poor clinical course in some IDH-mutant gliomas.

Methods
In this retrospective study, 183 patients with astrocytoma, IDH-mutant, CNS WHO grade 2 or 3 and diagnosed between 2001 and 2019 were included. Patients initially monitored by wait-and-scan strategies or treated with radiotherapy or temozolomide alone were studied. Patient data were correlated with outcome. Matched pair and subgroup analyses were conducted.

Results
Radiotherapy was associated with longer progression-free survival than temozolomide (6.2 vs 3.4 years, p = 0.02) and wait-and-scan strategies (6.2 vs 4 years, p = 0.03). Patients treated with radiotherapy lived longer than patients treated with temozolomide (14.4 vs 10.7 years, p = 0.02). Survival was longer in the wait-and-scan cohort than in the temozolomide cohort (not reached vs 10.7 years, p < 0.01). Patients from the wait-and-scan cohort receiving temozolomide at first progression had significantly shorter survival times than patients treated with any other therapy at first progression (p < 0.01). Post-surgical T2 tumor volume, contrast enhancement on MRI and WHO grade were associated with overall survival in univariate analyses (p < 0.01).

Conclusion
The results suggest superiority of radiotherapy over temozolomide and wait-and-scan strategies regarding progression-free survival and superiority of radiotherapy over temozolomide regarding overall survival. Our results are consistent with the notion that early temozolomide might compromise outcome in some patients.
Estimation of small area proportions under a bivariate logistic mixed model
Authors: Moretti Angelo 
Published: September 2022

AbstractA variety of data is of geographic interest but is not available at a small area level from large-scale national sample surveys. Small area estimation can be used to estimate parameters of target variables to detailed geographical scales based on relationships between the target variables and relevant auxiliary information. Small area estimation of proportions is a topic of great interest in many fields of study, where binary variables are diffused, such as in labour force, business, and social exclusion surveys. The univariate generalised mixed model with logit link function is widely adopted in this context. The small area estimation literature has shown that multivariate small area estimators, where correlations among response variables are taken into account, provide more efficient estimates than the traditional univariate approaches. However, the estimation problem of multivariate proportions has not been studied yet. In this article, we propose a bivariate small area estimator of proportions based on a bivariate generalised mixed model with logit link function. A simulation study and an application are presented to evaluate the good properties of the bivariate estimator compared to its univariate setting. We found that the extent of the improved efficiency of the bivariate over the univariate approach is associated with the degree of correlation of the area-specific random effects and the intraclass correlation, whereas it is not strongly related to the area sample size.
Climate change: north and south EU economies—an application of dynamic asymmetric panel data models
Authors: Adam Christos , Drakos Periklis 
Published: September 2022

Abstract
The need for a cleaner environment and wealthier economies has been highly recognized by European Union (EU) policymakers of the last years, as evidenced by the creation of a plethora of laws and regulations for reducing carbon dioxide emissions while promoting the economic prosperity of EU countries. Indeed, many works have been done in this field, remarking on climate change’s impacts on economies and the need for determinant environmental policies inside the EU. This paper investigates the effect of climate change on economic growth using nonlinear dynamic panel methods for 15 countries of the EU in the period 1981–2019. Specifically, it is examined the impact of temperature, precipitation, and CO2 emissions on economic growth. So, autoregressive distributed lags (ARDL) methods were employed, overcoming cross-dependency and also considering linearity and nonlinearity. The results showed that economic growth has positive nonlinear relationship with long-run temperature, but in short-run they have a symmetric negative association. Moreover, precipitation has long-run negative and a short-run positive relationship with economic growth. However, when CO2 emissions are added, then model’s performance is decreased, and precipitation has a positive effect on economic growth, but all others, except from temperature increase, become insignificant. Finally, actions should be taken for more stable climate conditions and consistent environmental policies by EU countries.
Graphical abstract
Computational prediction of dust deposition on solar panels
Authors: Dagher M. Mekawy , Kandil Hamdy A. 
Published: September 2022

AbstractThis research is concerned with performing computational fluid dynamics (CFD) simulations to investigate the air flow and dust deposition behavior around a ground-mounted solar PV panel. The discrete phase model (DPM) is adopted to model the gas-solid flow. The influence of the wind speed, the dust particle size, and the dust material on the dust deposition rate was investigated based on the environment of Cairo, Egypt. The wind speeds range between 1 and 11.5 m/s with an average of 3.7 m/s. It is found that increasing the wind speed decreases the dust deposition rate. For wind speeds higher than 2 m/s, it is found that increasing the dust particle diameter or the dust density increases the dust deposition rate. For wind speeds lower than 2 m/s, it is found that there is a critical particle size before which increasing the dust density causes dust deposition rate to increase and after which increasing the dust density decreases the dust deposition. The maximum percentage of deposition rate equals 10.8% and occurs for the dolomite dust material at a wind speed of 2 m/s and particles diameter of 150 μm.
Folk Psychological Models and the Metaphysics of Belief. A Reply to Curry
Authors: Poslajko Krzysztof 
Published: September 2022

AbstractThe aim of this paper is to show that Curry’s recent defence of the interpretivist approach to beliefs is unsuccessful. Curry tries to argue that his version of interpretivism, which is based on the model-theoretic approach to folk-psychological attributions, is well-suited to resisting the epistemological argument that is directed at interpretivism. In this paper, I argue that even if Curry’s defence is successful in this case, his theory does not have enough resources to solve the metaphysical problems of interpretivism. In particular, I argue that the model-theoretic version of interpretivism that Curry espouses does not explain the claim that beliefs are constituted by the process of attribution, which is central to the interpretivist project. In the final parts of the paper, I discuss the issue of the relation between interpretivism and other forms of the broadly superficial/deflationary approach to beliefs, especially dispositionalism. I contend that if one wants to adopt a superficial/deflationary approach, it is best not to adopt interpretivism as it is an unnecessarily complex and problematic version of this broad view.
Neocosmospora caricae sp. nov. and N. metavorans, two new stem and trunk canker pathogens on Ficus carica in Iran
Authors: Bolboli Zeinab , Mostowfizadeh-Ghalamfarsa Reza , Sandoval-Denis Marcelo , Jafari Moslem , Crous Pedro W. 
Published: September 2022

AbstractDuring 2018–2021, a survey was conducted in rainfed fig (Ficus carica L.) orchards throughout the Fars Province of Iran to investigate the occurrence of canker diseases, and to identify the causal organisms. Morphological and cultural characteristics, as well as multilocus phylogenetic analyses of the internal transcribed spacer (ITS) region of rDNA, RNA polymerase II second largest subunit (RPB2), and the translation elongation factor 1-alpha (TEF1), revealed that the recovered isolates from the infected fig trees clustered in clade 3 of Neocosmospora (Nectriaceae), including N. metavorans, and a new taxon described here as N. caricae sp. nov. Neocosmospora caricae is characterised by falcate, multiseptate, gently dorsoventrally curved macroconidia with poorly developed foot-shaped basal cells, ovoid, aseptate microconidia that cluster in false heads, and abundant terminal or intercalary chlamydospores. Pathogenicity tests indicated that isolates of both Neocosmospora species were pathogenic, causing stem canker and wood discolouration on fig saplings of “Sabz” and “Shah Anjeer” cultivars. The present study adds to existing knowledge on the aetiology of fig stem and trunk canker, and may provide essential information for developing effective integrated management strategies against canker diseases affecting fig orchards in Iran.
Long-Acting Injectable Cabotegravir for HIV Prevention: What Do We Know and Need to Know about the Risks and Consequences of Cabotegravir Resistance?
Authors: Parikh Urvi M. , Koss Catherine A. , Mellors John W. 
Published: September 2022

Abstract
Purpose of Review
Cabotegravir is a potent integrase strand transfer inhibitor (INSTI) recently approved as a long-acting injectable formulation for HIV prevention (CAB-LA). We summarize what is known about cabotegravir pharmacokinetics, activity, and emergence of resistance from in vitro, macaque and clinical studies, and we evaluate the risk of resistance from CAB-LA with on-time injections and after CAB-LA discontinuation.

Recent Findings
The accumulation of multiple INSTI mutations is required for high-level cabotegravir resistance, and the same mutation combinations may cause cross-resistance to dolutegravir, which is widely used for first-line antiretroviral therapy in low- and middle-income countries. Though CAB-LA was highly effective in preventing HIV, breakthrough infections did occur in trials of CAB-LA despite on-time injections, resulting in selection of single and combinations of INSTI resistance mutations.

Summary
As CAB-LA is scaled-up, prompt HIV diagnosis to prevent resistance, and resistance monitoring could help preserve the effectiveness of INSTIs for both HIV treatment and prevention.
Final benefit of primary percutaneous coronary intervention for ST-elevation myocardial infarction in older patients: long-term results of a randomised trial
Authors: de Boer M.-J. , Ottervanger J. P. , van’t Hof A. W. J. , Hoorntje J. C. A. , Suryapranata H. , Zijlstra F. ,   Zwolle Myocardial Infarction Study Group
Published: September 2022

AbstractBackgroundAlthough the short-term benefit of primary percutaneous coronary intervention (PCI) in elderly patients with ST-elevation myocardial infarction (STEMI) has been demonstrated, the final long-term survival benefit is as yet unknown.AimTo assess the final survival benefit of primary PCI as compared to thrombolytic therapy in patients over 75 years of age.MethodsPatients > 75 years with STEMI were randomised to either primary PCI or thrombolysis. Long-term data on survival were available for all patients.ResultsA total of 46 patients were randomised to primary PCI, 41 to thrombolysis. There were no significant differences in baseline variables. After a maximum of 20 years’ follow-up, all patients had passed away. The patients randomised to thrombolysis died after a mean follow-up duration of 5.2 years (SD 4.9) compared to 6.7 years (SD 4.8) in patients randomised to primary PCI (p = 0.15). Thus, the mean final survival benefit of primary PCI was 1.5 years.ConclusionThe final survival benefit of primary PCI as compared to thrombolysis in elderly patients with STEMI is 1.5 years and their life expectancy increases by 28.8%.