bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using the freshwater snail Biomphalaria glabrata (Say, 1818) as a biological model for ecotoxicology studies: a systematic review
Authors: Souza-Silva Gabriel , de Souza Clessius Ribeiro , Pereira Cíntia Aparecida de Jesus , Lima Walter dos Santos , Mol Marcos Paulo Gomes , Silveira Micheline Rosa 
Published: October 2022

Abstract
Over time, a growing increase in human pollutants in the aquatic environment has been observed. The global presence of residues in water bodies reinforces the need to develop improved methods to detect them and evaluate their ecotoxicological effects in the aquatic environment. Thus, this study aimed to present the main assays using B. glabrata as a biological model for ecotoxicological studies. We performed a systematic literature review with data published up to June 2022 in the Science Direct, PubMed, and SciELO databases. Twenty-six studies were selected for this review after screening. B. glabrata has been studied as an ecotoxicological model for different substances through toxicity, embryotoxicity, cytotoxicity, genotoxicity and bioaccumulation assays. Studies evaluating the impact of Biomphalaria glabrata exposure to several substances have reported toxic effects, behavioral and reproductive effects, and effects on their offspring. This review presents various assays using Biomphalaria glabrata as a biological model for ecotoxicological studies. The increasing number of studies conducted with the snail provides a preview of the snail’s potential as a biological model for ecotoxicological studies.
Peripheral Facial Nerve Palsy in Children: Etiology, Clinical Manifestations, Treatment And Prognosis
Authors: Bilge Serap , Mert Gülen Gül , Hergüner M Özlem , İncecik Faruk , Sürmelioğlu Özgür , Bilen Sevcan , Yılmaz Levent 
Published: October 2022

Abstract
Background:Sudden onset of unilateral weakness of upper and lower muscles of one side of the face is defined as peripheral facial nerve palsy. Peripheral facial nerve palsy is often idiopathic and sometimes it could be due to infectious, traumatic, neoplastic, and immune causes. This study aimed to report the causes and clinical evaluation and prognosis in children with peripheral facial nerve palsy.
Method:57 children under 18 years old, who were diagnosed with peripheral facial nerve palsy in Çukurova University, Balcalı Hospital between January 2018 and September 2021, were included in the study.
Results:The mean age of the children at the time of diagnosis was 9.6 ±7,4 years old. Thirty-two (56.1%) of the patients were female and 25 (43.9%) were male. A total of 57 patients were diagnosed with peripheral facial nerve palsy and categorized into many groups by etiology: idiopathic Bell’s palsy in 27 (47.5%), infectious in 11 (19.2%), traumatic in 6 (10.5%), and others in 13 (22.8%) patients were due to congenital, immune, neoplastic, Melkersson- Rosenthal syndrome, drug toxicity, and iatrogenic causes. Forty-six of the children achieved full recovery under oral steroids within 1-7 months. Four patients diagnosed with acute leukemia, myelodysplastic syndrome, Mobius syndrome and trauma did not recover and two patients (schwannoma, trauma) showed partial improvement. Five patients couldn't come to follow-up control.
Conclusion: Peripheral facial nerve palsy is a rare condition in children with different etiology. So giving attention to the red flag is very important. Peripheral facial nerve palsy in children is considered to have a good prognosis.
The Association of Maternal Insurance Status on Maternal and Neonatal Outcomes in Women with Hypertensive Disorders of Pregnancy
Authors: Allouch Farah , Burwick Richard , Gupta Megha , Bartal Michal Fishel , Bicocca Matthew , Chauhan Suneet , Wagner Stephen 
Published: October 2022

Abstract
The objective of this study was to examine the association between maternal insurance status and maternal and neonatal adverse outcomes in women who had hypertensive disorders in pregnancy. A population-based retrospective cohort study was undertaken using the US Vital Statistics dataset on Period Linked Birth-Infant Data from 2016-2020. The study population was restricted to non-anomalous births from women whose pregnancies were complicated by hypertensive disorders. Insurance status was categorized as private, Medicaid, self-pay and other. The primary outcome was a composite of maternal adverse outcomes, which included admission to the intensive care unit, unplanned hysterectomy, maternal blood transfusion or uterine rupture. We examined the role of prenatal care in these relationships using a mediation analysis with Kotelchuck’s Adequacy of Prenatal Care Utilization Index. Multivariable logistic regression models were used to estimate the association between maternal insurance status and adverse outcomes (using adjusted odds ratios [aOR] and 99% confidence interval [CI]). Of the 18,999,865 live births in the five-year study, 1,655,007 (8.7%) met the inclusion criteria. The frequency of the composite maternal adverse outcome was 1.3%. The maternal composite occurred more frequently in women with Medicaid (aOR = 1.13, 99% CI: 1.08, 1.18) or self-pay (aOR = 1.43, 95% CI: 1.28, 1.59) when compared to private insurance. Adjusting for prenatal care slightly attenuated this association, but remained significant. Among women with hypertensive disorders in pregnancy, women with Medicaid insurance or self-pay were more likely to experience maternal and neonatal adverse outcomes than women with private insurance.
Natural history and surgical outcomes of idiopathic spinal cord herniation
Authors: Nagoshi Narihito , Hirose Yuichiro , Tsuji Osahiko , Kono Hitoshi , Iida Tsuyoshi , Suzuki Satoshi , Takahashi Yohei , Nori Satoshi , Yagi Mitsuru , Matsumoto Morio , Nakamura Masaya , Watanabe Kota 
Published: October 2022

Abstract
Study Design

Retrospective multicenter study.

Objectives

Although surgery is frequently selected for the treatment of idiopathic spinal cord herniation (ISCH), its impact on functional outcomes has yet to be fully understood given the limited number of patients in previous studies. This study aims to evaluate the symptomatic history and surgical outcomes of ISCH.

Setting

Three institutions in Japan.

Methods

A total of 34 subjects with ISCH were retrospectively enrolled and followed up for at least 2 years. Demographic information, imaging findings, and clinical outcomes were collected. Functional status was assessed using the Japanese Orthopaedic Association score.

Results

The types of neurologic deficit were monoparesis, Brown–Sequard, and paraparesis in 5, 17, and 12 cases, with their mean disease duration being 1.2, 4.2, and 5.8 years, respectively. Significant differences in disease duration were observed between the monoparesis and Brown–Sequard groups (p < 0.01) and between the monoparesis and paraparesis groups (p = 0.04). Surgery promoted significantly better recovery rates from baseline. Correlations were observed between age at surgery and recovery rate (p < 0.01) and between disease duration and recovery rate (p = 0.04). The mean recovery rates were 82.6%, 51.6%, and 29.1% in the monoparesis, Brown–Sequard, and paraparesis groups, respectively. The monoparesis group had a significantly higher recovery rate than did the Brown–Sequard (p = 0.045) and paraparesis groups (p < 0.01).

Conclusions

Longer disease duration was correlated with the progression of neurologic deficit. Older age, and worse preoperative neurologic status hindered postoperative functional recovery. These results highlight the need to consider surgical timing before neurologic symptoms deteriorate.
Snoring-related polygenic risk and its relationship with lifestyle factors in a Korean population: KoGES study
Authors: Ryu Borim , Lee Sejoon , Heo Eunjeong , Yoo Sooyoung , Kim Jeong-Whun 
Published: October 2022

Abstract
Background
Few studies show the association between genetic and lifestyle factors and the risk of snoring. Polygenic risk scores (PRS) indicating genetic risks derived from genome-wide association study (GWAS) data have received much attention. Therefore, we investigated the relationships between PRS and other risk factors for snoring, including lifestyle.
Methods
To create a PRS for snoring, we combined genotyping with Korean Genome Epidemiology Study (KoGES). Associations were observed for sex, age, body mass index (BMI), alcohol consumption, smoking, physical activity, and sleep time. The PRS-KoGES was generated by PRS-Campos, derived from the European population. Using a multivariate logistic regression model, we assessed whether lifestyle factors mitigated the genetic risk of developing snoring.
Results
We included 3,526 snorers and 1,939 non-snorers in the KoGES cohort. The highest adjusted odds ratio for snoring was higher BMI, followed by male sex, older age, genetic factors as higher PRS, drinking experience, late sleep mid-time, smoking experience, and lower physical activity. The risk factors influenced by PRS were male sex, older age, alcohol consumption, smoking, lower BMI, low physical activity, and late sleep mid-time.
Conclusions
We identified the characteristics of lifestyle factors related to snoring influenced by PRS.
Study on the prediction effect of a combined model of SARIMA and LSTM based on SSA for influenza in Shanxi Province, China
Authors: Zhao Zhiyang , Zhai Mengmeng , Li Guohua , Gao Xuefen , Song Wenzhu , Wang Xuchun , Ren Hao , Cui Yu , Qiao Yuchao , Ren Jiahui , Chen Limin , Qiu Lixia 
Published: October 2022

Abstract
Background: Influenza is an acute respiratory infectious disease that is highly infectious and seriously damages human health. Reasonable prediction is of great significance to control the epidemic of influenza.
Methods: Our Influenza data were extracted from Shanxi Provincial Center for Disease Control and Prevention. Seasonal-trend decomposition using Loess (STL) was adopted to analyze the season characteristics of the influenza in Shanxi Province, China, from the 1st week in 2010 to the 52nd week in 2019. To handle the insufficient prediction performance of the seasonal autoregressive integrated moving average (SARIMA) model in predicting the nonlinear parts and the poor accuracy of directly predicting the original sequence, this study established the SARIMA model, the combination model of SARIMA and Long-Short Term Memory neural network (SARIMA-LSTM) and the combination model of SARIMA-LSTM based on Singular spectrum analysis (SSA-SARIMA-LSTM) to make predictions and identify the best model. Additionally, the Mean Squared Error (MSE), Mean Absolute Error (MAE) and Root Mean Squared Error (RMSE) were used to evaluate the performance of the models.
Results: The influenza time series in Shanxi Province from the 1st week in 2010 to the 52nd week in 2019 showed a year-by-year decrease with obvious seasonal characteristics. The peak period of the disease mainly concentrated from the end of the year to the beginning of the next year. The best fitting and prediction performance was the SSA-SARIMA-LSTM model. Compared with the SARIMA model, the MSE, MAE and RMSE of the SSA-SARIMA-LSTM model decreased by 38.12, 17.39 and 21.34%, respectively, in fitting performance; the MSE, MAE and RMSE decreased by 42.41, 18.69 and 24.11%, respectively, in prediction performances. Furthermore, compared with the SARIMA-LSTM model, the MSE, MAE and RMSE of the SSA-SARIMA-LSTM model decreased by 28.26, 14.61 and 15.30%, respectively, in fitting performance; the MSE, MAE and RMSE decreased by 36.99, 7.22 and 20.62%, respectively, in prediction performances.
Conclusions: The fitting and prediction performances of theSSA-SARIMA-LSTM model were better than those of the SARIMA and theSARIMA-LSTM models. Generally speaking, we can apply the SSA-SARIMA-LSTM model to the prediction of influenza, and offer a leg-up for public policy.
Cost-effectiveness analysis of multiple gastric cancer screening strategies in Northwest China based on a population program: a Markov modeling study
Authors: Liu Rong , Zheng Ya , Zhou Lingshan , Nie Peng , Wang Youfa , Wang Yuping , Guan Quanling , Ji Rui , Guo Qinghong , Chen Zhaofeng , Zhang Zhiyi , Fan Ping , Hu Xiaobin , An Feng , Zan Xiangyi , Lu Linzhi , Zhou Yongning 
Published: October 2022

AbstractBackground Gastric cancer remains a significant global health problem and poses heavy public health and economic burdens on the health system. This study aimed to compare cost-effectiveness among multiple gastric cancer screening strategies and identify the most cost-effective one in Northwest China based on a population-based cohort study using a Markov model. Methods Based on the real-world data, a Markov model was developed to evaluate the cost-effectiveness of 21 screening strategies with various screening methods, starting ages, stopping ages, and screening intervals versus no screening for a high-risk gastric cancer population in China. The primary outcomes were quality-adjusted life-years (QALY), costs, effectiveness, and the incremental cost-effectiveness ratio (ICER). One-way and probabilistic sensitivity analyses explored uncertainty. Results Our baseline model of annual endoscopic screening for individuals aged 40 to 75 years was the cost-effective strategy, with an ICER of US$ 545.79/QALY compared with no screening. In the scenario analysis, only theH. pyloriscreen-and-treat from 20 years strategy was non-dominated, with an ICER of US$ 157.41/QALY, and all other systems were dominated (providing less benefit but higher cost). Using the US$ 15,000 per QALY, all selected screening strategies for gastric cancer were cost-effective in the high-risk region of Northwest China. One-way and probabilistic sensitivity analyses demonstrated that the results are robust. Conclusions This modelling study provides evidence for the cost-effectiveness of an endoscopic screening program for gastric cancer in the high-risk region of China. Primary prevention appears more cost-effective than secondary prevention strategies. If primary prevention is not an option, secondary prevention strategies should be considered. All selected screening strategies seem to be cost-effective in the high-incidence area of Northwest China.
Investigations on Effects of Titanium Dioxide (TiO2) Nanoparticle in Combination with UV Radiation on Breast and Skin Cancer Cells
Authors: Bilkan Mustafa Tuğfan , Çiçek Zehra , Kurşun Ayşe Gülnihal Canseven , Özler Mehmet , Eşmekaya Meriç Arda 
Published: October 2022

Abstract
In this study, we have investigated the chemotherapeutic potential of titanium dioxide (TiO2) nanoparticles on skin and breast cancer cells. The cells have treated with a 75 µg/ml concentration of titanium dioxide and then exposed to UV-A radiation. The combined effects of titanium dioxide and UV-A radiation on cell viability, cell cycle, plasma membrane, mitochondrial membrane potentials and apoptotic activity of the cells were investigated. As a result of the research, an increase was observed in the viability of cells treated with 75 µg/ml titanium dioxide concentration, while a significant decrease in cell viability was observed for both cell types when UV-A radiation and TiO2 were applied together. The results also showed that the percentage of apoptotic cells increased as a result of UV + TiO2 exposure. Accordingly, it can be said that TiO2 nanoparticles may research as potential chemotherapeutic agents for skin and breast cancers, especially in the presence of UV radiation.
Nonlinear dynamics analysis of gear system considering time-varying meshing stiffness and backlash with fractal characteristics
Authors: Xia Heng , Meng Fanshan , Zhang Xin , Wang Jiaxu , Jin Yulin 
Published: October 2022

Abstract
The microscopic topography of tooth surface affects the nonlinear dynamic characteristics of the gear system. However, few studies have fully taken into account the effects of microscopic topography on time-varying meshing stiffness (TVMS) and backlash in gear dynamics. In this context, this study derives TVMS and time-varying backlash with fractal characteristics based on fractal theory, and introduced them into a 6-DOF nonlinear dynamic model. With various nonlinear dynamics analysis tools, the dynamic characteristics of the gear system under different fractal parameters are investigated. The results indicate that the increase of the fractal dimension or the decrease of the characteristic scale coefficient leads to a smoother tooth surface, larger TVMS, and smaller amplitude of backlash. The effect of fractal dimension is more sensitive than characteristic scale coefficient. Furthermore, in the low-speed region, the increase of fractal dimension has a positive effect on the dynamic response of the system, and can reduce the amplitude of transmission error. In the high-speed region, the opposite is true. It is worth pointing out that the influence of fractal dimension on gear dynamic characteristics is nonlinear. Considering the machining cost and dynamic response of gear, the fractal dimension of 1.5 is the best choice. The influence of characteristic scale coefficient on system dynamics is similar to that of fractal dimension but weak.
Factors related to terminal cancer patients’ trust in palliative care doctors from the point of view of bereaved family members: a qualitative study
Authors: Murahashi Masaki , Tamba Kaichiro , Takanashi Tomoaki 
Published: October 2022

Abstract
Background
Trust is a key factor in achieving a good death. However, few studies have focused on factors that help terminal cancer patients to establish trusting relationships with their palliative care doctors. We therefore designed this exploratory qualitative study to identify factors related to terminal cancer patients’ trust in their doctors.
Methods
We conducted a semi-structured interview with 18 participants for data collection, and we opted to use the grounded theory approach in our analysis of the data.
Results
Our data revealed seven factors: 1) caring attitude, 2) symptom management, 3) courteous and specific explanations, 4) long-term involvement in the patient’s care, 5) being faced with inevitable death, 6) good impression of the institution, and 7) referral by a trusted doctor. These factors are categorized under three main themes: [1] palliative care doctors, [2] terminal cancer patients, and [3] institutional and professional reputation. Three of these factors are uniquely characteristic of palliative care: symptom management, being faced with inevitable death, and referral by a trusted doctor.
Conclusions
In this study, we clarified the seven factors with a qualitative study evaluating the perspective of bereaved family caregivers on aspects that related to their corresponding patient`s trust in palliative care physicians. In future, more quantitative research is needed to assess the validity of the factors identified here and to understand how these factors are associated with quality of death.
QTL mapping and genetic map for the ornamental sunflower in China
Authors: Liu Jixia , Shan Junjian , wang ping 
Published: October 2022

Abstract
The quantitative trait locus (QTL) mapping and genetic map are of great significance for the ornamental sunflower in China. In this study, a total of 956.50Mbp data were obtained, the average Q30 was 93.76%, the average GC content was 42.43%, and the GC distribution of the parents and F2 population of the ornamental sunflowers was normal. At the same time, the double-end comparison efficiency of control data was 90.28%, and the enzyme digestion efficiency was 92.01%. SLAF library construction was normal. Furthermore, a total of 734,893 SLAF markers were obtained, among which 127,855 were polymorphic SLAF markers, 38,908 could be used for genetic map construction, and the effective polymorphism of the parents was 5.29%. Moreover, we constructed a total of 17 linkage groups, with 6,181 markers in the QTL mapping, the total map distance was 2,608.66cM, the marker integrity in the figure above was 99%, the proportion of double exchange was 0.05, the sequencing depth of the parents was 42.455x, and the progeny was 9.24x. The relationship of traits (plant height, stem diameter, disk diameter, number of petals, leaf number, stigma color, petal color, petiole color) and QTL mapping was closely related to show the best of ornamental effect.
Respiratory Severity Score during the first three hours of life as a predictor for CPAP failure and need for late surfactant administration
Authors: Zapata Henry , Becker Heather , Lasarev Michael , Fort Prem , Guthrie Scott , Kaluarachchi Dinushan 
Published: October 2022

Abstract
Background
Preterm infants often develop CPAP failure. These infants miss the advantages of early rescue surfactant therapy. In this study, we evaluate the utility of Respiratory Severity Score (RSS) during the first three hours of life (HOL) as a predictor for CPAP failure.
Methods
We conducted a post-hoc analysis of patients who received usual care in the AERO-02 clinical trial. Univariate and multivariable logistic regression were used to assess whether the RSS summary measures were associated with the odds of surfactant administration.
Results
Study involved 146 infants. Sixty-four infants (45%) received surfactant within the first 72 hours. Administration of surfactant was associated with the mean RSS (p < 0.01) and the linear trend (p < 0.01).
Conclusion
We demonstrated that RSS during the first three HOL can predict CPAP failure and need for surfactant administration. Optimal RSS cutoffs for early rescue surfactant therapy need to be determined in large cohort studies.
Does repeated sprinting alter the hamstring shear modulus pattern and mechanical parameters in football players with hamstring strain injury history? - A retrospective study
Authors: Pimenta Ricardo , Lopes Tomás , Bruno Paula , Veloso António 
Published: October 2022

Abstract

Background: Hamstring strain injuries (HSI) occur particularly in the later stages of a football match, suggesting that fatigue may play an important role. Moreover, sprint is the principal mechanism to sustain an HSI since it demands the hamstrings muscle group. It has been reported that a higher contribution of BFlh in the load sharing pattern could possibly explain the greater injury rate in BFlh.
Objective: To compare the effects of a (i) repeated sprint protocol on the sprint performance, hamstrings shear modulus pattern and mechanical parameters between players with and without previous HSI; and (ii) between limbs with HSI and their healthy contralateral limbs on the hamstrings shear modulus pattern and mechanical parameters.
Methods: One hundred and five professional and semiprofessional football field players were invited to participate in this study during the pre-season 2021/2022 (June-July), resulting in a sample size of 210 limbs with 46 sustaining HSI in the previous 2 years.
Results: No differences were seen between injured and non-injured players regarding their sprint performance, hamstrings shear modulus pattern and mechanical parameters, except for the early rate of torque development (0-50ms) with BFlh injured limbs displaying higher rates than their contralateral (injured: 0.48±21 N/ms; contralateral 0.40±0.18 N/ms; p=0.005; η2p=0.469).
Conclusion: The present study provides evidence for no differences regarding sprint performance, hamstrings load sharing pattern and mechanical parameters between players with previous HSI in the last 2 years and non-injured players, although an increase in early rate of torque development was seen in BFlh-injured limbs compared to their healthy counterpart. Therefore, the results can possibly suggest that the duration between injury and screening could recover the differences between injured-control and injured-contralateral groups.