bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambulance deployment without transport - A retrospective difference analysis for the description of emergency interventions without patient transport in Bavaria
Authors: Dax Florian , Trentzsch Heiko , Lazarovici Marc , Hegenberg Kathrin , Kneißl Katharina , Hoffmann Florian , Prückner Stephan 
Published: October 2022

Abstract
Background:

Not all patients who call the ambulance service are subsequently transported to hospital. This study describes factors that influence patient transport rates.

Method:

This is a retrospective cross-sectional study based on data from all Integrated Dispatch Centres of the Free State of Bavaria in 2018. Included were ambulance deployments without emergency physician involvement, which were subdivided into ambulance deployments without transport (RoT) and ambulance deployments with transport (TP). Patient transport quota (PTQ) were determined for the primary reasons for deployment and for the different community types. On-scene time was compared for calls with and without patient transport. Differences were tested for statistical significance (α = 0.05) using Chi2 tests and the odds ratio (OR) was calculated to determine differences between groups.

Results:

Of 510,145 deployments, 147,621 (28.9%) could be classified as ambulance deployments without transport (RoT) and 362,524 (71.1%) as ambulance deployments with transport (TP). The lowest PTQ was found for reasons with fire brigade involvement ("fire alarm system" 0.6%, "fire with EMS" 5.4%) and "personal emergency response system active alarm" (18.6%). The highest PTQs were for "childbirth/delivery" (96.9% PTQ) and "trauma" (83.2% PTQ). A lower PTQ is observed in large cities than in smaller cities or rural communities; in the community type Large City, the odds ratio for RoT is 2.02 [95% confidence interval 1.98–2.06] referenced to Rural Community. The median on-scene time for RoT was 20.8 minutes (n = 141,052) and for TP was 16.5 minutes (n = 362,524). The shortest on-scene times for RoT were identified for the reasons "fire alarm system" (9.0 minutes) and "personal emergency response system active alarm" (10.6 minutes).

Conclusion:

This study shows that the transport quota depends on the reason for deployment and the type of municipality. Particularly low PTQs are found in fire brigade and personal emergency response system operations. The engagement times of the rescue vehicle are increased for RoT deployments. The study could not provide a rationale for this and further research is needed.
Trial registration:
This paper is part of the study "Rettungswageneinsatz ohne Transport” [“Ambulance deployment without transport”] (RoT), which was registered in the German Register of Clinical Studies under the number DRKS00017758.
Portal blood Flow following Sleeve Gastrectomy; a before- after study
Authors: Alamdari Nasser Malekpour , Salevatipour Babak , Besharat Sara , Abbasi Maryam , Taherpour Niloufar , Mirahmadi Alireza , Rashnoo Fariborz , Zeinalpour Adel , Farsi Yeganeh , Hajimirzaei Seyed Hossein , Soori Mohsen 
Published: October 2022

Abstract
Backgrounds: Portal Venous Thrombosis after sleeve gastrectomy can be due to changes in portal vein flow. The present study was designed to compare the portal vein flow before and after sleeve surgery using Doppler ultrasonography to investigate any changes in the type of portal vein flow after the sleeve surgery.
Methods: This study is a prospective study in which all people (n=60) referred to our hospital in Tehran from June to August 2020 for Sleeve gastrectomy surgery were evaluated. Participants’ information was collected from patients’ medical records through a researcher-made checklist. Using proper statistical tests, all statistical analyses significant at less than 0.05 were analyzed.
Results: Among 60 patients under sleeve gastrectomy, 51 (85%) were females. The mean age was 35.63 ± 9.004. Based on postoperative follow-up (3 days after sleeve gastrectomy), portal vein flow has decreased (proportion: 0.3667, 95% CI: 0.25 – 0.49 cc/min) in 22 patients (36.67%). In these patients, both the mean of portal vein flow (955.90 ± 177.88 cc/min) and the mean of portal vein diameter (10.43 ± 0.80 mm) was significantly decreased (P<0.001).
Conclusion: The complications following the sleeve surgery are rare, but considering the various reports of thrombosis after sleeve surgery, it is necessary to pursue high-risk people and keep them under consideration to prevent any complications after surgery.
Adjuvant Melatonin for Uveal Melanoma (AMUM): Protocol for a Randomized Open-label Phase III Study
Authors: Hagström Anna , Omar UG Ruba Kal , Stålhammar  
Published: October 2022

AbstractBackground Uveal melanoma is the most common primary intraocular tumor in adults. In Sweden, 60 to 100 patients are diagnosed with the disease each year. Almost half of the patients develop metastases, with a median survival time of 1 year once metastases are detected. The primary ocular tumor is typically treated with either enucleation or brachytherapy, and no adjuvant treatment is added. Melatonin is an indolamine hormone that has improved survival in previous trials with patients diagnosed with various cancers, including advanced cutaneous melanoma. Side effects have been mild. We aim to investigate if adjuvant treatment with melatonin for 5 years following diagnosis of non-metastasized uveal melanoma can decrease the occurrence of metastases. Methods An open-label, prospective, 5-year randomized clinical trial (RCT) will be conducted at St. Erik Eye Hospital. Patients (n = 100) diagnosed with non-metastatic uveal melanoma will be included in this trial and randomized to either treatment with adjuvant melatonin 20 mg (4 tablets of 5 mg) at 10 pm for five years, or to standard follow-up (control group). The primary outcome measurement is the number of patients that have developed metastases 5 years after randomization. The secondary outcomes are overall survival, risk of developing other cancers, overall survival after detection of metastases, and differences in the occurrence of adverse events (AE) and serious adverse events (SAE) between the groups. Discussion Melatonin has been found to positively impact our immune system, inhibit angiogenesis, stimulate apoptosis in malignant cells, and act as a potent antioxidant. Previous clinical trials have used similar doses of melatonin with positive results, particularly in advanced stages of cancer. Previous animal and human studies have found the toxicity of the hormone to be low. Considering the potential benefits and limited risks of melatonin, as well as its global availability, it may be a suitable candidate for an adjuvant treatment in patients with uveal melanoma. Trial registration Our trial protocol has been approved and registered by the Swedish Medical Products Agency on June 22, 2022 (EudraCT 2022-500307-49-00). Our trial registration number is NCT05502900 and the date of registration is August 16, 2022.
Novel development of Zinc oxide coated Carbon nanoparticles from Pineapples leaves using sol gel method for optimal adsorption of Cu 2+ and reuse in a latent fingerprint.
Authors: Fouda-Mbanga Bienvenu-Gael , Kriveshini Pillay , Tywabi-Ngeva Zikhona 
Published: October 2022

Abstract
This study underlines a latest approach of preparing Nitrogen carbon nanoparticles fused on zinc oxide nanoparticles nanocomposite (N-CNPs/ZnONPs nanocomposite) for the uptake of copper ions (Cu2+) from wastewater using a sol gel method and applied the metal loaded adsorbent in the latent fingerprint application. N-CNPs/ZnONPs nanocomposite proved to be a good sorbent for the optimal adsorption of Cu2+ at pH 8 and 0.05 g dosage. Langmuir isotherm best fitted the process with the maximum adsorption capacity of 285.71 mg/g that was superior to most values reported in other studies for the removal of Cu2+. At 25 oC, the adsorption was spontaneous and endothermic. Furthermore, Cu2+-N-CNPs/ZnONPs nanocomposite revealed to be sensitive and selective for latent fingerprint (LFP) identification on a variety of porous surfaces. As a result, it is an excellent identifying chemical for latent fingerprint recognition in forensic science.
A novel insight on SARS-CoV-2 S-derived fragments in the control of the host immunity
Authors: Bastos Thais Sibioni Berti , de Paula André Guilherme Portela , Luz Rebeca Bosso dos Santos , Garnique Anali , Belo Marco , Eto Silas , Fernandes Dayanne , Ferraris Fausto , De Pontes Leticia , Franca Tabata , Barcellos Leonardo , Veras Flavio , Bermejo Pamela , Guidelli Giovanna , Maneira Carla , Mello Fellipe , Teixeira Gleidson , Pereira Gonçalo , Fernandes Bianca , Galindo-Villegas Jorge , Sanches Paulo Ricardo , Braz Helyson , Jorge Roberta , Malafaia Guilherme , Cilli Eduardo , Olivier Danilo , Amaral Marcos , Medeiros Renata , Condino-Neto Antonio , Carvalho Luciani , Machado-Santelli Glaucia , charlie-silva Ives , Braga Tarcio , Souza Giovane 
Published: October 2022

Abstract
Despite all efforts to combat the pandemic of COVID-19, we are still living with high numbers of infected persons, an overburdened health care system, and the lack of an effective and definitive treatment. Understanding the pathophysiology of the disease is crucial for the development of new technologies and therapies for the best clinical management of patients. Since the manipulation of the whole virus requires a structure with an adequate level of biosafety, the development of alternative technologies, such as the synthesis of peptides from viral proteins, is a possible solution to circumvent this problem. In addition, the use and validation of animal models is of extreme importance to screen new drugs and to compress the organism's response to the disease. Peptides derived from recombinant S protein from SARS-CoV-2 were synthesized and validated by in silico, in vitro and in vivo methodologies. Macrophages and neutrophils were challenged with the peptides and the production of inflammatory mediators and activation profile were evaluated. These peptides were also inoculated into the swim bladder of transgenic zebrafish larvae at 6 days post fertilization to mimic the inflammatory process triggered by the virus, which was evaluated by confocal microscopy. In addition, toxicity and oxidative stress assays were also developed. In silico and molecular dynamics assays revealed that the peptides bind to the ACE2 receptor stably and interact with receptors and adhesion molecules, such as MHC and TCR, from humans and zebrafish. Macrophages stimulated with one of the peptides showed increased production of NO, TNF-α and CXCL2. Inoculation of the peptides in zebrafish larvae triggered an inflammatory process marked by macrophage recruitment and increased mortality, as well as histopathological changes, similarly to what is observed in individuals with COVID-19. The use of peptides is a valuable alternative for the study of host immune response in the context of COVID-19. The use of zebrafish as an animal model also proved to be appropriate and effective in evaluating the inflammatory process, comparable to humans.
Novel magnetic graphoxide/biochar composite derived from tea for multiple SAs and QNs antibiotics removal in water
Authors: Pang Wei , Wang Yonghui , Li Shuang , Luo Yuanyuan , Wang Guanyu , Hou Jian , Han Tie , Gao Zhixian , Guo Qingbin , Zhou Huanying 
Published: October 2022

Abstract
Increasing antibiotics pollution is becoming an urgent public health issue. Biochar is a kind of promising solution for antibiotic removal in aqueous environment. However, the adsorption and degradation performance of pristine biochar was limited because of the relatively lower specific surface. The remediation efficiencies could be highly improved through developing new biochar-based composites which have high interactions and bonding abilities with antibiotic. In this study, a novel magnetic graphoxide/biochar composite (mGO/TBC) was fabricated as an efficient and recyclable persulfate (PS) activator for degradation and removal of sulfonamides (SAs) and quinolones (QNs) antibiotics. Based on the synergism presorption and degradation of graphoxide and biochar, the removal rates of mGO/TBC for sarafloxacin hydrochloride, sulfadimethoxine, sulfapyridine, sulfado xine, sulfamonomethoxine, sulfachloropyridazine, enrofloxacin, and ciprofloxacin were increased above 85%. Quenching experiment and ESR analysis had proved that 1O2, •OH and SO4•− from mGO/TBC/PS system were the primary oxidation active species to degrade SAs and QNs. Furthermore, the mGO/TBC is easy to be batch produced due to simple synthesis steps. It is a promising substrate for antibiotic bioremediation with good application prospects.
Evaluating the Benefits of a High-Fidelity Simulation Workshop for Head and Neck Examination Skills
Authors: White Jessica , Mattingly Laura , Johnston Elizabeth , Sengupta Samarpita 
Published: October 2022

Abstract
Background
The COVID-19 pandemic has presented unique challenges for health professions education particularly in the area of teaching physical examination skills. As safety restrictions have limited close physical contact, programs have had to utilize alternate teaching methods to ensure students can practice and develop necessary skills. Accordingly, the UT Southwestern Masters in Physician Assistant Studies program developed a high-fidelity simulation workshop using simulation mannequins and task trainers to allow students to practice, under faculty guidance, components of the head and neck examination.
Methods
We collected quantitative and qualitative data using surveys to determine the impact of this innovative teaching tool on student confidence with performing the head and neck examination. In addition, experienced faculty members evaluated student competency using traditional rubrics.
Results
We found significant improvements in self-reported confidence and skill in the otoscopic and ophthalmic examinations individually as well as in the comprehensive head and neck examination. These self-reported improvements also correlated with scores on faculty-graded examinations.
Conclusions
Our findings impact not only the confidence and proficiency of examination skills in this student cohort, but have the potential to improve future health professions education.
Comparing the Effectiveness of Two Surgical Techniques for Treating Lower Lid Epiblepharon in Children: A Randomized Controlled Trial
Authors: Takeuchi Masaki , Matsumura Nozomi , Ohno Tomoko , Fujita Takeshi , Asano Mizuki , Mizuki Nobuhisa 
Published: October 2022

Abstract
A multicenter randomized controlled trial was conducted to compare the effectiveness of incisional and nonincisional surgical techniques for treating lower lid epiblepharon in children. The study included 89 eyes from 50 children aged 3–15 years (mean, 7.5 ± 2.4 years) with clinically significant moderate lower lid epiblepharon. Patients were randomly assigned to either incisional (modified Hotz procedure with lid margin splitting; 45 eyes of 25 patients) or nonincisional (44 eyes of 25 patients) surgery groups. Treatment outcomes were evaluated 6 months after surgery and classified into three grades: well-corrected, no ciliary touch, and superficial keratitis; under-corrected, ciliary touch, and superficial keratitis; and over-corrected, eyelid ectropion, and insufficient eyelid closure. Changes in astigmatism were compared between the two techniques after surgery. Incisional surgery provided a significantly higher percentage (77.8%) of well-corrected treatment results (P = 0.026; odds ratio, 2.88; 95% confidence interval, 1.07–8.22) than nonincisional surgery (55.4%). The mean change in astigmatism pre and post surgery was − 0.24 ± 0.42 and − 0.01 ± 0.47 D in the incisional and nonincisional surgery groups, respectively. The improvement in astigmatism 6 months after surgery was significantly higher in the incisional surgery group than in the nonincisional surgery group (P = 0.008). The incisional surgical treatment for epiblepharon in children resulted in a higher number of well-corrected patients, indicating an absence of both ciliary touch and superficial keratitis as well as statistically significant improvements in astigmatism correction.
Study on the correlation between phase angle and nutritional status and sarcopenia in patients with cancer pain
Authors: Chen Yajun , Zhang Ping , Zeng Yaqi , Li Chunlei , Dong Jie , Li Yueying , Wang Yujie , Liu Heji , Wang Kun 
Published: October 2022

Abstract
Objective
To observe the relationship between PA measured using the bioelectrical impedance method and nutritional risk, nutritional status, and sarcopenia in patients with cancer pain.
Methods
146 patients with cancer pain were enrolled.NRS, NRS-2002, PG-SGA, anthropometrics, blood biochemical examination, body composition analysis and other methods were performed for pain assessment, nutritional risk screening, and nutritional status assessment. Patients were divided according to PA. For the low PA and the normal PA groups, the correlation between PA and pain score, nutritional risk,and nutritional indicators was analyzed.
Results
TP,ALB,CHE,HB,PALB,and HGS in the low PA group were lower than those in the normal PA group (P < 0.05);the low PA group had higher NRS,NRS-2002,and PG-SGA scores than the normal PA group (P < 0.05); ICW, ECW, PRO, FM, FFM, ASMM, BCM, ASMI in the low PA group were significantly lower than those in the normal PA group (P < 0.05);PA and HGS, PALB, ALB,TP,ICW,PRO,FFM,ASM,BCM,ASMI were positively correlated (P < 0.05);PA was negatively correlated with pain score, nutritional risk, and PG-SGA score (P < 0.05).
Conclusion
PA is an economical and effective objective indicator that reflects the nutritional status of patients with cancer pain and is closely related to the degree of pain, nutritional status, and muscle loss in patients. The detection of the phase angle helps to evaluate the nutritional status of patients with
Identification of potential ferroptosis hub genes in acute-on-chronic liver failure based on bioinformatics analysis and experimental verification
Authors: Kuang Meixia , Cai Longhui , Zhao Jing , Huang Liqiao , Ji Yichun , Lv Bingyao , Kuang Weihong 
Published: October 2022

Abstract
Background
Ferroptosis has an important role in developing Acute-on-chronic Liver Failure (ACLF). The present project aimed to identify and validate the potential ferroptosis-related genes in ACLF by bioinformatics analysis and experimental verification.
Materials and Methods
GSE139602 was obtained from the GEO dataset and intersected with ferroptosis genes. Ferroptosis-related differentially expressed genes (DEGs) between the ACLF tissue and healthy group were analyzed using bioinformatics methods. Analysis of enrichment, protein-protein interactions, and hub genes were conducted. Finally, we performed real-time quantitative PCR(RT-qPCR) to validate the expression of the hub genes.
Results
A total of 35 ferroptosis-related DEGs were screened, which were involved in biosynthesis of amino acids, peroxisome, and fluid shear stress and atherosclerosis. PPI network analysis indicated five ferroptosis-related hub genes namely HRAS, TXNRD1, NQO1, PSAT1, and SQSTM1. The experimental validation indicates that the expression levels of HRAS, TXNRD1, NQO1, and SQSTM1 were lower, while PSAT1 was higher in ACLF rats than that of healthy group.
Conclusions
Our findings reveal that PSAT1, TXNRD1, HRAS, SQSTM1 and NQO1 may affect the development of ACLF by regulating ferroptotic events. These results provide a valid reference for potential mechanisms and identification in ACLF.
The Reality Check of Community Clinic in Bangladesh: A Case Study of Two Selected Villages of Naogaon District
Authors: BakiBillah Abul Hasan 
Published: October 2022

Abstract
Community Clinic (CC) as a new horizon in ensuring primary healthcare in Bangladesh has been working astoundingly since its inception. Reportedly, some of the CCs are not working effectively that’s why the beneficiaries, the villagers, are seeking care from other professionals. To address the underlying reasons of ineffectiveness of the CC in the site was the key objective of this study. Lack of work in that particular context motivates to pursue this study. Due to the financial constraint, the sampling site, Naogaon district, was purposively selected. Then the randomly selected upazila, Raninagar, was undertaken. Applying multi-stage random sampling technique, primary data of 100 household of two villages, as per the secondary data, were collected. From the empirical investigation, it is addressed that the key determinants of demand for health care from the CC; the level of education and level of income; are not playing a robust role. Instead of those, the problem of comparative low use rate of the CC lies on the determinants of supply-side; the unavailability of the CHCP and the drugs, which ultimately strengthens the traditional outlook towards the CC by the villagers. Once the provision of drugs is ended, the CC becomes literally meaningless except few responsibilities conducted by the health workers. Along with the government’s strong commitment, some reforms; formation of Village Solidarity Group’ keeping educational institute at the centre; can transform the scenario drastically.
Burnout prevalence and its associated factors among Chinese webcasters
Authors: Wang Hanqin , Yang Shang , Zhang Fushen , Gao Xiao , Chen Shi , Liu Ziwei 
Published: October 2022

Abstract
Background
Webcaster is a young and high-income job, with a low barrier to entry, attracting a large number of people entering, however, huge job stress, job-related health problems, lack of labour and social security are leading to a wide unhealthy employee turnover. Data on the prevalence of burnout in webcaster are very limited. This study aims to investigate the prevalence and correlates of burnout among Chinese webcaster.
Methods
A total of 358 webcasters were recruited from 4 companies in Changsha, China. Socio-demographic information, career-related factors, job stress, interpersonal support, and burnout were collected by a self-design questionnaire through online platform.
Results
Nearly half (46.09%, 95% CI: 40.90 ~ 51.02%) of the webcasters met the high burnout criteria. In multiple logistic regression analysis, risk factors associated with burnout include lower education (junior high school and below: OR = 9.87), cyber violence (OR = 6.79), losing fans (OR = 4.37), longer live broadcast duration (> 8h per day: OR = 3.57), negative performance appraisal (OR = 2.61), longer resting (OR = 2.56), low income (OR = 2.41), live broadcasting time at day (OR = 2.30), higher seniority (OR = 2.34), job stress (OR = 1.19). The protective factor is interpersonal support (OR = 0.83).
Conclusions
Burnout is prevalent in Chinese webcasters. Dynamic risk factors include losing fans, longer live broadcast duration, negative performance appraisal, low income and daily live broadcast time, as well as job stress. Static risk factors include lower education, cyber violence, and higher seniority. The protective factor is interpersonal support. these findings may contribute to the risk management and health promotion of webcaster’s burnout.