bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Risk Factors Associated With Antihypertensive Treatment Success Employing Data Mining Techniques
Authors: Şen Selçuk , Demirkol Denizhan , Kaşkal Mert , Gezer Murat , Bucak Ayşenur Yaman , Gürel Nermin , Selalmaz Yasemin , Erol Çiğdem , Üresin Ali Yağız 
Published: November 2022

Objective: This study aimed to evaluate the effects of potential risk factors on antihypertensive treatment success. Methods: Patients with hypertension who were treated with antihypertensive medications were included in this study. Data from the last visit were analyzed retrospectively for each patient. To evaluate the predictive models for antihypertensive treatment success, data mining algorithms (logistic regression, decision tree, random forest, and artificial neural network) using 5-fold cross-validation were applied. Additionally, study parameters between patients with controlled and uncontrolled hypertension were statistically compared and multiple regression analyses were conducted for secondary endpoints. Results: The data of 592 patients were included in the analysis. The overall blood pressure control rate was 44%. The performance of random forest algorithm (accuracy = 97.46%, precision = 97.08%, F1 score = 97.04%) was slightly higher than other data mining algorithms including logistic regression (accuracy = 87.31%, precision = 86.21%, F1 score = 85.74%), decision tree (accuracy = 76.94%, precision = 70.64%, F1 score = 76.54%), and artificial neural network (accuracy = 86.47%, precision = 83.85%, F1 score = 84.86%). The top 5 important categorical variables (predictive correlation value) contributed the most to the prediction of antihypertensive treatment success were use of calcium channel blocker (−0.18), number of antihypertensive medications (0.18), female gender (0.10), alcohol use (−0.09) and attendance at regular follow up visits (0.09), respectively. The top 5 numerical variables contributed the most to the prediction of antihypertensive treatment success were blood urea nitrogen (−0.12), glucose (−0.12), hemoglobin A1c (−0.12), uric acid (−0.09) and creatinine (−0.07), respectively. According to the decision tree model; age, gender, regular attendance at follow-up visits, and diabetes status were identified as the most critical patterns for stratifying the patients. Conclusion: Data mining algorithms have the potential to produce predictive models for screening the antihypertensive treatment success. Further research on larger populations and longitudinal datasets are required to improve the models.
The quantitative evaluation of retinal layers after resolution of subretinal fluid in acute central serous chorioretinopathy
Authors: Dursun Erdem , Dursun Gamze Akyüz 
Published: November 2022

Purpose To evaluate the average retinal layer thicknesses in eyes with unilateral acute central serous chorioretinopathy (CSC) (with subretinal fluid (SRF)) and after complete resolution of SRF in these eyes and to compare the results with those obtained in healthy eyes. Methods Fifty-four eyes of 27 patients with unilateral acute CSC (CSC in active phase) who had complete resolution of SRF and 25 eyes of 25 healthy control subjects enrolled in this retrospective study. The average thicknesses of the retinal layers were measured by segmentation analysis of optical coherence tomography at baseline and 6 months after complete resolution of SRF. Results The mean outer nuclear layer (ONL) thickness was significantly lower in eyes with CSC than in fellow eyes (p < 0.001). The mean ONL thickness was increased after resolution of SRF, but still low compared to unaffected fellow eye and the increment was not statistically significant (p > 0.05). There were significant strong inverse correlations between visual acuity and ONL thicknesses at baseline and 6 months after complete resolution of SRF (p < 0.001, r = − 0.810; p < 0.001, r = − 0.705, respectively). Conclusion ONL thickness was thinned in cases with acute CSC, and although there was some increment in ONL thickness 6 months after complete resolution of SRF, it was still thinner compared to unaffected fellow eyes.
A qualitative exploration of autistic mothers’ experiences I: Pregnancy experiences
Authors: Hampton Sarah , Man Joyce , Allison Carrie , Aydin Ezra , Baron-Cohen Simon , Holt Rosemary 
Published: November 2022

Pregnancy may pose a number of physical and healthcare-related challenges for autistic people, who experience differences in sensory processing and can face barriers to accessing healthcare. However, little research has explored autistic pregnancy experiences. Semi-structured interviews were conducted with 24 autistic and 21 non-autistic women during the third trimester of pregnancy. Thematic analysis revealed that the autistic group experienced heightened sensory and physical symptoms during pregnancy compared with the non-autistic group. Autistic participants were sometimes reluctant to disclose their diagnosis to healthcare professionals and felt that professionals lacked autism knowledge. While both groups appreciated clear information about their care, autistic participants further highlighted the need for detailed information and being given time to process verbal information. The autistic group also highlighted the need for sensory adjustments in healthcare settings. The findings indicate ways in which prenatal healthcare can be improved for autistic people, including sensory and communication adjustments. There is a need for greater autism-related training for prenatal healthcare professionals to ensure that autistic people receive appropriate support. Lay abstract Little is known about how autistic people experience pregnancy. We interviewed 24 autistic and 21 non-autistic women during pregnancy to find out about their experiences. Autistic participants had more physical difficulties, such as nausea and pain, during pregnancy than non-autistic participants. They also sometimes felt that healthcare professionals, such as midwives, did not have a good understanding of autism and they did not always feel comfortable telling professionals about their autism diagnosis. Autistic participants told us that they needed professionals to communicate with them clearly and to make changes during appointments such as dimming lights. This research shows that autistic people would benefit from changes to pregnancy appointments and that more training about autism would help maternity care professionals to support autistic people during pregnancy.
Unidirectional language bias: The Implicit Association Test with Spanish and English in Miami
Authors: Callesano Salvatore , Carter Phillip M. 
Published: November 2022

Aims and objectives/purpose/research questions: Automatic preferences and implicit biases toward Spanish and English in the context of Miami are tested. We investigate whether implicit language bias is conditioned by social factors (i.e., ethnicity, gender, first language) as well as different linguistic stimuli (orthographic vs oral/aural). Design/methodology/approach: Three Implicit Association Test (IAT) experiments were designed and implemented. IAT 1 uses semantically neutral furniture terms in English and Spanish with visual attribute words. IAT 2 uses an oral/aural condition employing US Latinx city names produced with both Spanish and English phonology. In IAT 3, we use nonce words to represent the categories of English and Spanish as well as positive/negative visual imagery for the attributes. Data and analysis: d-scores were automatically calculated considering response latency and accuracy. Data were subjected to linear regression for between- and within-experiment analyses as well as a post hoc regression considering participants born outside of the United States. Findings/conclusions: The within-experiment analysis for IAT 1 showed an effect of country of birth. The between-experiment analysis showed country of birth and the experiments themselves to be significant. Length of residency for the non-US born group was also a significant factor. Across the three experiments, none of the 89 participants demonstrated a strong automatic preference for Spanish. Originality: This study is conducted in the largest situation of bilingualism in the Americas and is the first study to examine nonconscious bias toward bilingual participants’ own language varieties in the United States. Significance/implications: Despite the popular construction of Miami as “Spanish-speaking,” results of this study demonstrate strong nonconscious automated preferences for English among participants in Miami and raise questions about language, power, and the vitality of Spanish in South Florida.
Occupational health patients’ parallel use of primary- and secondary-care services and linkage to work disability: A follow-up study in Finland
Authors: Reho Tiia , Atkins Salla , Korhonen Mikko , Siukola Anna , Viljamaa Mervi , Sumanen Markku , Uitti Jukka , Sauni Riitta 
Published: November 2022

Aims: This study aimed to investigate occupational health (OH) primary-care patients’ use of other health-care services and whether parallel use affects their likelihood to have sickness absences (SA) or disability pensions (DP). Methods: Primary-care services in Finland are provided through three parallel health-care sectors, all available to the working population: public, private and OH sectors. Patients may also be referred to secondary care. This follow-up study combines real-world medical record data containing SA data from a nationwide OH provider with health-care attendance data from public and private primary-care sectors and public secondary care, sociodemographic data and DP decisions. Patients between 18 and 68 years of age who used OH primary care at least once during the study years 2014–2016 were included. The total study population comprised 59,650 patients. Odds ratios were used to analyse association between parallel service use and SA or DP. Results: Females and patients with a lower educational level were more likely to use services in other health-care sectors in addition to OH than others. Those patients who used any other health-care sector in addition to OH primary care had an increased likelihood of having long SA or receiving DP. Conclusions: OH primary-care patients using the services of several health-care sectors in parallel have an increased likelihood of receiving disability benefits – either SA or DP. There is need for care coordination to ensure adequate measures for work-ability support.
Indoor radon concentration measurements in workplaces and their impact on health risk assessment
Authors: Loffredo Filomena , Quarto Maria 
Published: November 2022

Radon is the main source of exposure to ionizing radiation for the general population. In Italy, very little has been investigated to determine occupational radon exposure in workers. In this study, radon concentrations of various workplaces type were measured for 1 year using SSNTD CR-39. Q–Q plot and Shapiro–Wilks statistical test showed that radon concentrations are not log-normally distributed. The geometric mean of radon concentration was found to be 97 Bq/m3 with a geometric standard deviation of 3. The mean effective dose to workers has been calculated and found to be 1.4 mSv/y. Finally, for estimation of cancer risks, the lifetime risk and lung cancer cases per year per million have been calculated.
Multi-layered nanofiber membranes: Preparation, characterization, and application in wastewater treatment
Authors: Islam Md Nazrul , Yıldırım Bekir , Maryska Jiri , Yalcinkaya Fatma 
Published: November 2022

Over the last few decades, micropollutants have been found in the natural surface water, and their presence poses a series of risks to living organisms in the aquatic biotope. Nanofiber membranes have been shown as a new strategy for separating micron-size pollutants due to their tight pore size and high water permeability. Here, a high-efficient multi-layered nanofiber membrane with improved mechanical strength was prepared using the lamination technique. First, polyamide 6 (PA6), polyacrylonitrile (PAN), and polyvinylidene fluoride (PVDF) nanofibers webs were selected. Then nanofibers were laminated on support under various temperatures. Prepared membranes were characterized using SEM, contact angle, pore size, and air permeability tests. The significance of lamination condition on membrane structure was investigated experimentally and statically. The membranes were examined for the treatment of synthetic micropollutants. According to the results, PAN and PA6 nanofiber membranes exhibited high water permeability (over 3000 L/(m2hbar)) under low pressure, whereas PVDF membranes showed zero permeability. Besides, the prepared nanofiber membranes could separate micropollutants from water with up to 99.91% separation efficiency. Prepared nanofiber membranes hold great promise for practical applications in environmental remediation.
Prediction of disability in trigger finger: a cross-sectional and longitudinal study
Authors: Namaldi Seda , Kuru Cigdem Ayhan , Kuru Ilhami 
Published: November 2022

The aim of this prospective study of 55 patients was to analyse the cross-sectional and longitudinal relationship between disability and physical and psychological variables after conservative treatment of trigger finger and to determine the predictive factors for the post-treatment disability score and change in disability score. The primary outcome measure was the Disabilities of the Arm, Shoulder, and Hand questionnaire. Potential predictive factors included pain, number of triggering events, depression, anxiety and kinesiophobia. Disability correlated strongly with anxiety, moderately with pain and depression and weakly with triggering and kinesiophobia. The change in depression score correlated significantly with the change in disability score. Post-treatment pain and anxiety scores accounted for 47% of the explained variance in disability score. Improvement in depression after treatment accounted for 18% of the explained variance in disability change score. Psychological variables appear to be potential predictors of disability. Level of evidence: IV
Inter-rater and intra-rater reliability of finger goniometry measured from screenshots taken via video consultation
Authors: Johnson Dane , Barradas Rodrigo , Newington Lisa 
Published: November 2022

The purpose of this study was to assess the intra- and inter-rater reliability of using screenshots and handheld manual goniometers to assess range of finger movements during video consultations. Twenty-seven hand therapists measured finger joint angles from four different screenshots using two different goniometers. Results were compared within and between participants using the intraclass correlation coefficient (ICC). The ICC grading for both intra- and inter-rater reliability was moderate to excellent for all joints and both goniometers. Clinicians can measure finger joint angles from a screenshot with good reliability. The protocol used in this study can be used in remote video consultations as a no-cost substitute for in-person goniometry. Level of evidence: II
Bacterial DNA amplifies neutrophilic inflammation in IL-17-exposed airways
Authors: Mues Nastaran , Martin Richard J. , Alam Rafeul , Schaunaman Niccolette , Dimasuay Kris Genelyn , Kolakowski Christena , Wright Clyde J. , Zheng Lijun , Chu Hong Wei 
Published: November 2022

BackgroundNeutrophilic asthma (NA) is associated with increased airway interleukin (IL)-17 and abnormal bacterial community such as dominance of nontypeableHaemophilus influenzae(NTHi), particularly during asthma exacerbations. Bacteria release various products including DNA, but whether they cooperate with IL-17 in exaggerating neutrophilic inflammation is unclear. We sought to investigate the role of bacteria-derived DNA in airway neutrophilic inflammation related to IL-17-high asthma and underlying mechanisms (e.g.Toll-like receptor 9 (TLR9)/IL-36γ signalling axis).MethodsBacterial DNA, IL-8 and IL-36γ were measured in bronchoalveolar lavage fluid (BALF) of people with asthma and healthy subjects. The role of co-exposure to IL-17 and bacterial DNA or live bacteria in neutrophilic inflammation, and the contribution of the TLR9/IL-36γ signalling axis, were determined in cultured primary human airway epithelial cells and alveolar macrophages, and mouse models.ResultsBacterial DNA levels were increased in asthma BALF, which positively correlated with IL-8 and neutrophil levels. Moreover, IL-36γ increased in BALF of NA patients. Bacterial DNA or NTHi infection under an IL-17-high setting amplified IL-8 production and mouse lung neutrophilic inflammation. DNase I treatment in IL-17-exposed and NTHi-infected mouse lungs reduced neutrophilic inflammation. Mechanistically, bacterial DNA-mediated amplification of neutrophilic inflammation is in part dependent on the TLR9/IL-36γ signalling axis.ConclusionsBacterial DNA amplifies airway neutrophilic inflammation in an IL-17-high setting partly through the TLR9 and IL-36γ signalling axis. Our novel findings may offer several potential therapeutic targets including TLR9 antagonists, IL-36γ neutralising antibodies and DNase I to reduce asthma severity associated with exaggerated airway neutrophilic inflammation.
Biomedical named entity recognition with the combined feature attention and fully-shared multi-task learning
Authors: Zhang Zhiyu , Chen Arbee L. P. 
Published: November 2022

AbstractBackgroundBiomedical named entity recognition (BioNER) is a basic and important task for biomedical text mining with the purpose of automatically recognizing and classifying biomedical entities. The performance of BioNER systems directly impacts downstream applications. Recently, deep neural networks, especially pre-trained language models, have made great progress for BioNER. However, because of the lack of high-quality and large-scale annotated data and relevant external knowledge, the capability of the BioNER system remains limited.ResultsIn this paper, we propose a novel fully-shared multi-task learning model based on the pre-trained language model in biomedical domain, namely BioBERT, with a new attention module to integrate the auto-processed syntactic information for the BioNER task. We have conducted numerous experiments on seven benchmark BioNER datasets. The proposed best multi-task model obtains F1 score improvements of 1.03% on BC2GM, 0.91% on NCBI-disease, 0.81% on Linnaeus, 1.26% on JNLPBA, 0.82% on BC5CDR-Chemical, 0.87% on BC5CDR-Disease, and 1.10% on Species-800 compared to the single-task BioBERT model.ConclusionThe results demonstrate our model outperforms previous studies on all datasets. Further analysis and case studies are also provided to prove the importance of the proposed attention module and fully-shared multi-task learning method used in our model.
Population dynamics and demographic history of Eurasian collared lemmings
Authors: Lord Edana , Marangoni Aurelio , Baca Mateusz , Popović Danijela , Goropashnaya Anna V. , Stewart John R. , Knul Monika V. , Noiret Pierre , Germonpré Mietje , Jimenez Elodie-Laure , Abramson Natalia I. , Vartanyan Sergey , Prost Stefan , Smirnov Nickolay G. , Kuzmina Elena A. , Olsen Remi-André , Fedorov Vadim B. , Dalén Love 
Published: November 2022

Abstract
Background
Ancient DNA studies suggest that Late Pleistocene climatic changes had a significant effect on population dynamics in Arctic species. The Eurasian collared lemming (Dicrostonyx torquatus) is a keystone species in the Arctic ecosystem. Earlier studies have indicated that past climatic fluctuations were important drivers of past population dynamics in this species.

Results
Here, we analysed 59 ancient and 54 modern mitogenomes from across Eurasia, along with one modern nuclear genome. Our results suggest population growth and genetic diversification during the early Late Pleistocene, implying that collared lemmings may have experienced a genetic bottleneck during the warm Eemian interglacial. Furthermore, we find multiple temporally structured mitogenome clades during the Late Pleistocene, consistent with earlier results suggesting a dynamic late glacial population history. Finally, we identify a population in northeastern Siberia that maintained genetic diversity and a constant population size at the end of the Pleistocene, suggesting suitable conditions for collared lemmings in this region during the increasing temperatures associated with the onset of the Holocene.

Conclusions
This study highlights an influence of past warming, in particular the Eemian interglacial, on the evolutionary history of the collared lemming, along with spatiotemporal population structuring throughout the Late Pleistocene.
Valosin-containing protein Asp395Gly mutation in a patient with frontotemporal dementia: a case report
Authors: Kobayashi Ryota , Naruse Hiroya , Kawakatsu Shinobu , Iseki Chifumi , Suzuki Yuya , Koyama Shingo , Morioka Daichi , Ishiura Hiroyuki , Mitsui Jun , Ohta Yasuyuki , Tsuji Shoji , Toda Tatsushi , Otani Koichi 
Published: November 2022

Abstract
Background
Variants in the valosin-containing protein (VCP) gene were identified as one of the causes for inclusion body myopathy associated with Paget disease of the bone and frontotemporal dementia (FTD). Previously identified pathogenic variants in VCP are associated with frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) pathologically, but p.Asp395Gly VCP was recently reported to cause familial FTD with tauopathy characterized by neurofibrillary tau tangles (NFT) and not FTLD-TDP. We describe the clinical and genetic findings of a patient with p.Asp395Gly valosin-containing protein (VCP), who was diagnosed with FTD without a family history and in the absence of muscle or bone disease comorbidity.

Case presentation
The patient was a 62-year-old man, who developed atypical depression at the age of 37 years. Subsequently, he presented with self-centered behavior at the age of 45 years. The self-centered behavior intensified from around the age of 50 years, which was accompanied by the development of executive dysfunction; therefore, he visited our hospital at 52 years of age. Magnetic resonance imaging revealed bilateral frontal lobe atrophy. Brain perfusion single-photon emission computed tomography revealed bilateral frontal lobe hypoperfusion. The patient fulfilled the diagnostic criteria for behavioral variant of FTD. Ten years after the diagnosis, computed tomography of the trunk and limbs, muscle biopsy, and bone scintigraphy revealed the absence of concomitant muscle and bone disease. The concentrations of cerebrospinal fluid (CSF) total tau and phosphorylated tau proteins were 389 pg/mL and 53.2 pg/mL (cut-off: 50 pg/mL), respectively. Genetic analyses were performed using the whole-exome and Sanger sequencing methods. We identified p.Asp395Gly VCP in this patient with pure FTD.

Conclusions
p.Asp395Gly VCP was identified in a patient with likely sporadic FTD without concomitant muscle and bone disease. The CSF analysis suggested that our patient may have FTD due to NFT accumulation similar to the familial FTD patients with p.Asp395Gly VCP recently reported. Our findings suggest that a genetic search for the pathogenic variants of VCP should be considered not only for familial FTD, but also for patients with sporadic FTD, even in the absence of comorbid muscle or bone disease.