bluuebunny/crossref_metadata_2025_split huggingface dataset:
PIDANA KERJA SOSIAL SEBAGAI PEMBAHARUAN HUKUM PIDANA DALAM PERKARA TINDAK PIDANA KORUPSI
Authors: Zuraidah Zuraidah 
Published: October 2022

The study is intended to give an idea of the growing number of corruption in Indonesia from year to year the authors consider it a gross inpunishment on the convict in corruption, resulting in the absence of a jerusal effect to be one of the goals of idomy.
The problem which language writers in this study are how to carry out criminal sanctions on the charges of corruption in Indonesia is under the law on the elimination of criminal corruption and how a criminal social work formula is a renewed criminal law in Indonesia in the case of criminal corruption crime.
Analysis using the approach of the law (conceptual approach), policy (approach , and conceptual approach . The results of this study prove that the criminal work social (community service order) that has been formulated as a main criminal from short-term prison crimes can be effectively formulated as a further criminal against corruption in Indonesia.
A conclusion to the problem raised by the problem of criminal corruption can be effective when the primary goal of elimination is achieved.

Penelitian ini dibuat dengan tujuan memberikan gambaran tentang terus meningkatnya kasus korupsi di Indonesia dari tahun ketahun penulis anggap sebagai ketidakmaksimalan hukuman yang diberikan terhadap terpidana kasus korupsi sehingga tidak adanya efek jera yang diharapkan sebagai salah satu tujuan pemidanaan.
Permasalahan yang penulis bahasa pada penelitian ini adalah Bagaimana Pelaksanaan Sanksi Pidana dalam Perkara Tindak Pidana Korupsi di Indonesia berdasarkan Undang-Undang Pemberantasan Tindak Pidana Korupsi dan Bagaimana formulasi pidana kerja sosial sebagai pembaharuan hukum pidana di Indonesia dalam perkara tindak pidana korupsi.
Analisis dengan menggunakan pendekatan undang-undang (statute approach), kebijakan (policy approach), dan konseptual (conceptual approach). Hasil studi ini membuktikan bahwa pidana kerja social (community service order) yang selama ini dirumuskan sebagai pidana pokok dari pidana penjara jangka pendek dapat diformulasikan secara efektif sebagai pidana tambahan terhadap tindak pidana korupsi di Indonesia.
Kesimpulan dari rumusan masalah yang diangkat yaitu pemidanaan tindak pidana korupsi dapat berjalan efektif bila tujuan utama dalam pemidanaan tercapai.
The Comparison of the Effectiveness of Acceptance and Commitment Therapy and Spirituality Therapy in Reducing Anxiety in Women with Breast Cancer
Authors: Zari Moin Zahra , Abolmaali Alhosseini Khadijeh , Sirafi Mohammad Reza 
Published: October 2022

Background: The experience of anxiety as a bad experience creates a different behavioral, cognitive, and emotional response that preserves annoying thoughts and inefficient beliefs. The present study aimed to investigate the effectiveness of acceptance and commitment therapy (ACT) and spirituality therapy in reducing anxiety in women with breast cancer in Tehran.
Methods: This was a pre-test/post-test quasi-experimental design research with a control group and a three-month follow-up. The statistical population comprised women with breast cancer visiting the Gynecological Ultra-Specialized Cancer Center of Khatam-al-Anbya Hospital in Tehran in 2021. In total, 45 women with breast cancer were selected and randomly divided into two experimental groups and one control group (n=15). The first and second experimental groups underwent eight 60-minute sessions of ACT and eight 60-minute sessions of spiritual therapy, respectively. The research instruments included the Penn State Worry Questionnaire (PSWQ). The collected data were analyzed using repeated measures ANOVA.
Results: The results showed that ACT and spiritual therapy significantly reduced generalized anxiety scores in the experimental groups compared to the control group (P<0.01). Moreover, the absence of anxiety significantly increased in the two experimental groups that underwent ACT and spirituality therapy compared to the control group (P<0.01). However, ACT and spirituality therapy did not differ significantly in their effects on the dependent variables.
Conclusion: This study achieved promising results concerning the applicability of ACT and spirituality therapy in reducing anxiety in women with breast cancer. Based on the results, holding ACT and spirituality therapy workshops may exert beneficial effects on reducing anxiety in women with breast cancer.
ORGANIZATIONAL SEQUENCE, TURN-TAKING, AND ROLE-SWITCHING IN A HUMAN-ROBOT COMMUNICATION
Authors: Febriyanti Anggy Fian , Irham Irham 
Published: October 2022

Research on artificial intelligence has developed rapidly since the last fifteen years. Social studies and humanities scholars including linguists has put much attention on the relation between human-robot communications from wider and multidiscipline perspectives. Nonetheless, there is only a dearth of research investigating turn, sequence, and role-switching in humanoid interaction. Focusing on Sophia, the humanoid robot, the present study aims to examine three elements of dialogic- communication related to conversation. The present study applies a descriptive qualitative approach to investigate the research subject. Data consists of forms of utterances taken from two Sophia’s video that will be categorized into a sequence of organization, turn-taking, and role-switching functions. The results of present study show that Sophia is able to perform human-like interactional features in terms of providing adequate adjacency pairs, turn-taking, and a sequence of organizations. The present study shows that Sophia is not able to interrupt a conversation because it needs a brief moment of silence before replying.
Implementasi skema pengacakan subcarrier OFDM dengan algoritma RSA pada NI-USRP
Authors: Sa’adah Nihayatus , Astawa I Gede Puja , Sudarsono Amang 
Published: October 2022

Keamanan jaringan nirkabel merupakan salah satu hal terpenting dalam sistem komunikasi. Karena sinyal dikirim dari pengirim melalui saluran nirkabel, tidak hanya penerima yang sah, tetapi juga penyadap dapat menangkap dan menyimpan sinyal informasi dengan mudah. Penelitian ini mengeksplorasi skema keamanan komunikasi nirkabel dimana skema yang digunakan adalah pengacakan subcarrier. Pemancar dan penerima harus disinkronkan untuk mengembalikan subcarrier ke posisi semula. Sistem ini menggunakan algoritma RSA sebagai sinkronisasi. Teknologi keamanan pengacakan subcarrier diimplementasikan pada sistem OFDM. Sistem OFDM diimplementasikan menggunakan perangkat USRP. Hasil yang diperoleh dari penelitian ini membuktikan bahwa teknik keamanan yang digunakan tidak menurunkan kinerja sistem, bahkan dapat mengurangi jumlah kesalahan bit akibat teknik sinkronisasi. Dengan teknik sinkronisasi algoritma RSA, dari jarak pengujian 1 meter, 2 meter, dan 5 meter. Pada jarak 1 meter didapatkan hasil terbaik dengan penurunan error bit dari 19,04% menjadi 0% pada 32-QAM dan penurunan error bit dari 28,57% menjadi 4,76% pada 64-QAM.

ABSTRACT
Wireless network security is one of the essential things in communication systems. Since the signal is sent from the sender through a wireless channel, the legitimate receiver and eavesdropper can easily capture and store signal information. This study explores a wireless communication security scheme where the scheme used is subcarrier randomization. The transmitter and receiver must be synchronized to return the subcarrier to its original position. This system uses the RSA algorithm as synchronization. Subcarrier randomization security is implemented in OFDM system. OFDM system is implemented using USRP. The results from this study prove that security techniques don't reduce system performance, and can even reduce the number of errors due to synchronization techniques with RSA synchronization technique, with 1 meter, 2 meters, and 5 meters experiments. At 1meter distance is the best result with bit error drop from 19.04% to 0% on 32-QAM and a bit error drop from 28.57% to 4.76% on 64-QAM.
Formulation of a novel antibacterial topical treatment based on Magnetite-Buforin-II-silver nanobioconjugates
Authors: Muñoz Laura N. , Jaramillo Valentina , Gantiva-Diaz Mónica , Cifuentes Javier , Muñoz-Camargo Carolina , Cruz Juan C. , González Barrios Andrés Fernando 
Published: October 2022

Community acquired infections caused by Meticillin-resistant Staphylococcus aureus (MRSA) have become a growing concern due to its impact on the world public health. This microorganism is a commonly spreading pathogen associated predominantly with skin infections and connected to other more severe conditions (septic shock, and generalized infection). The lack of highly effective antibiotics and treatments to control skin infections with S. aureus has led to the search of novel therapies using alternative agents such as antimicrobial peptides (AMPs). In order to obtain a viable administration route to counteract superficial skin infections (impetigo, abscesses, furuncles, and cellulitis), a topical formulation based on Magnetite-Buforin-II-silver nanobioconjugates as active antibacterial agents was designed by their dispersion in O/W concentrated emulsions. The prepared topical characterization indicated that O/W emulsions were stable in time, the droplets size remained within the appropriate values (∼1 µm) and their rheological properties, such as pseudoplastic and shear-thinning behavior, remained unchanged for up to 3 months. Additionally, hemolysis and platelet aggregation tests were acceptable (i.e., 14.72 ± 2.62% and 8.06 ± 2.90%, respectively) in compliance with the ISO-10993 standard. Furthermore, the treatment reduced significantly (p &lt; 0.0001) the growth of both clinical isolated MRSA and wild Type S. aureus strains as evidenced by the contact diffusion method. These results are important in the context of proposing new alternatives that allow manage effectively the threat posed by the antibiotic resistant bacterial strains, which jeopardize the lives of thousands of people every year.
OMIXCARE: OMICS technologies solved about 33% of the patients with heterogeneous rare neuro-developmental disorders and negative exome sequencing results and identified 13% additional candidate variants
Authors: Colin Estelle , Duffourd Yannis , Tisserant Emilie , Relator Raissa , Bruel Ange-Line , Tran Mau-Them Frédéric , Denommé-Pichon Anne-Sophie , Safraou Hana , Delanne Julian , Jean-Marçais Nolwenn , Keren Boris , Isidor Bertrand , Vincent Marie , Mignot Cyril , Heron Delphine , Afenjar Alexandra , Heide Solveig , Faudet Anne , Charles Perrine , Odent Sylvie , Herenger Yvan , Sorlin Arthur , Moutton Sébastien , Kerkhof Jennifer , McConkey Haley , Chevarin Martin , Poë Charlotte , Couturier Victor , Bourgeois Valentin , Callier Patrick , Boland Anne , Olaso Robert , Philippe Christophe , Sadikovic Bekim , Thauvin-Robinet Christel , Faivre Laurence , Deleuze Jean-François , Vitobello Antonio 
Published: October 2022

Purpose: Patients with rare or ultra-rare genetic diseases, which affect 350 million people worldwide, may experience a diagnostic odyssey. High-throughput sequencing leads to an etiological diagnosis in up to 50% of individuals with heterogeneous neurodevelopmental or malformation disorders. There is a growing interest in additional omics technologies in translational research settings to examine the remaining unsolved cases.Methods: We gathered 30 individuals with malformation syndromes and/or severe neurodevelopmental disorders with negative trio exome sequencing and array comparative genomic hybridization results through a multicenter project. We applied short-read genome sequencing, total RNA sequencing, and DNA methylation analysis, in that order, as complementary translational research tools for a molecular diagnosis.Results: The cohort was mainly composed of pediatric individuals with a median age of 13.7 years (4 years and 6 months to 35 years and 1 month). Genome sequencing alone identified at least one variant with a high level of evidence of pathogenicity in 8/30 individuals (26.7%) and at least a candidate disease-causing variant in 7/30 other individuals (23.3%). RNA-seq data in 23 individuals allowed two additional individuals (8.7%) to be diagnosed, confirming the implication of two pathogenic variants (8.7%), and excluding one candidate variant (4.3%). Finally, DNA methylation analysis confirmed one diagnosis identified by genome sequencing (Kabuki syndrome) and identified an episignature compatible with a BAFopathy in a patient with a clinical diagnosis of Coffin-Siris with negative genome and RNA-seq results in blood.Conclusion: Overall, our integrated genome, transcriptome, and DNA methylation analysis solved 10/30 (33.3%) cases and identified a strong candidate gene in 4/30 (13.3%) of the patients with rare neurodevelopmental disorders and negative exome sequencing results.
RETRACTED: Survivin knockdown alleviates pathological hydrostatic pressure-induced bladder smooth muscle cell dysfunction and BOO-induced bladder remodeling via autophagy
Authors: Chen Guo , Chen Shuang , Di Xingpeng , He Shengyin , Liu Yugao , Qu Rui , Luo Yi , Liu Yuebai , Yang Luo 
Published: October 2022

Aim: Bladder outlet obstruction (BOO) leads to bladder wall remodeling accompanying the progression from inflammation to fibrosis where pathological hydrostatic pressure (HP)-induced alteration of bladder smooth muscle cells (BSMCs) hypertrophic and excessive extracellular matrix (ECM) deposition play a pivotal role. Recently, we have predicted survivin (BIRC5) as a potential hub gene that might be critical during bladder fibrosis by bioinformatics analyses from rat BOO bladder, but its function during BOO progression remains unknown. Here, we investigated the role of survivin protein on bladder dysfunction of BOO both in vitro and in vivo.Methods: Sprague-Dawley female rats were divided into three groups: control group, BOO group, and BOO followed by the treatment with YM155 group. Bladder morphology and function were evaluated by Masson staining and urodynamic testing. To elucidate the underlying mechanism, hBSMCs were subjected to pathological HP of 200 cm H2O and co-cultured with the presence or absence of survivin siRNA and/or autophagy inhibitor 3-MA. Autophagy was evaluated by the detection of Beclin1 and LC3B-II expression, proliferation was conducted by the EdU analysis and PCNA expression, and fibrosis was assessed by the examination of Col 1 and Fn expression.Results: BOO led to a gradual alteration of hypertrophy and fibrosis of the bladder, and subsequently induced bladder dysfunction accompanied by increased survivin expression, while these histological and function changes were attenuated by the treatment with YM155. HP significantly increased survivin expression, upregulated Col1 and Fn expression, enhanced proliferation, and downregulated autophagy markers, but these changes were partially abolished by survivin siRNA treatment, which was consistent with the results of the BOO rat experiment. In addition, the anti-fibrotic and anti-proliferative effects of the survivin siRNA treatment on hBSMCs were diminished after the inhibition of autophagy by the treatment with 3-MA.Conclusion: In summary, the upregulation of survivin increased cell proliferation and fibrotic protein expression of hBSMC and drove the onset of bladder remodeling through autophagy during BOO. Targeting survivin in pathological hBSMCs could be a promising way to anti-fibrotic therapeutic approach in bladder remodeling secondary to BOO.
A maximum-type microbial differential abundance test with application to high-dimensional microbiome data analyses
Authors: Li Zhengbang , Yu Xiaochen , Guo Hongping , Lee TingFang , Hu Jiyuan 
Published: October 2022

BackgroundHigh-throughput metagenomic sequencing technologies have shown prominent advantages over traditional pathogen detection methods, bringing great potential in clinical pathogen diagnosis and treatment of infectious diseases. Nevertheless, how to accurately detect the difference in microbiome profiles between treatment or disease conditions remains computationally challenging.ResultsIn this study, we propose a novel test for identifying the difference between two high-dimensional microbiome abundance data matrices based on the centered log-ratio transformation of the microbiome compositions. The test p-value can be calculated directly with a closed-form solution from the derived asymptotic null distribution. We also investigate the asymptotic statistical power against sparse alternatives that are typically encountered in microbiome studies. The proposed test is maximum-type equal-covariance-assumption-free (MECAF), making it widely applicable to studies that compare microbiome compositions between conditions. Our simulation studies demonstrated that the proposed MECAF test achieves more desirable power than competing methods while having the type I error rate well controlled under various scenarios. The usefulness of the proposed test is further illustrated with two real microbiome data analyses. The source code of the proposed method is freely available at https://github.com/Jiyuan-NYU-Langone/MECAF.ConclusionsMECAF is a flexible differential abundance test and achieves statistical efficiency in analyzing high-throughput microbiome data. The proposed new method will allow us to efficiently discover shifts in microbiome abundances between disease and treatment conditions, broadening our understanding of the disease and ultimately improving clinical diagnosis and treatment.
The relationship between mean platelet volume lymphocyte ratio and collateral circulation in patients with chronic total coronary occlusion
Authors: Niu Ming-Hui , Liu Peng-Hui , Liu Ze-Hua , Zhu Jun-Wei , Guo Rong , He Fei 
Published: October 2022

ObjectiveTo correlate mean platelet volume lymphocyte ratio (MPVLR) and coronary collateral circulation (CCC) in patients with chronic total occlusion (CTO).Materials and methodsA total of 643 patients who were hospitalized at a single large academic medical center from January 2020 to October 2021 and had CTO lesions in at least one major coronary artery confirmed by coronary angiography were retrospectively analyzed. Patients were divided according to the Rentrop criteria into poorly formed CCC (Rentrop grade 0–1, n = 235) and well-formed CCC (Rentrop grade 2–3, n = 408) groups. Mean platelet volume lymphocyte ratio (MPVLR) was calculated from routine laboratory data (MPV divided by lymphocyte count). The clinical data of the two groups were compared, and relationships between MPVLR and CCC formation were analyzed.ResultsThe MPVLR of patients with poorly formed CCC was significantly higher than that of patients with well-formed CCC (7.82 ± 3.80 vs. 4.84 ± 1.42, P &lt; 0.01). The prevalence of diabetes mellitus and C-reactive protein levels were significantly higher in the poor CCC group than in the good CCC group (P &lt; 0.01), while the proportions of patients with CTO or multivessel lesions in the right coronary artery were significantly lower in the poor CCC group than in the good CCC group (P &lt; 0.01). Multivariate logistic regression analysis identified MPVLR (OR: 2.101, 95% CI: 1.840–2.399, P &lt; 0.01), C-reactive protein level (OR: 1.036, 95% CI: 1.008–1.064, P &lt; 0.05), a history of diabetes mellitus (OR: 2.355, 95% CI: 1.532–3.621, P &lt; 0.01), and right coronary CTO ratio (OR: 0.313, 95% CI: 0.202–0.485, P &lt; 0.01) as independent risk factors for CCC formation. The area under the ROC curve of MPVLR for predicting poorly formed CCC was 0.82 (95% CI: 0.784–0.855, P &lt; 0.01), the best cut-off point was 6.02 and the sensitivity and specificity of MPVLR for predicting poorly formed CCC were 72.3 and 82.4%, respectively.ConclusionIn patients with coronary CTO, MPVLR was negatively correlated with CCC and a high MPVLR level was an independent predictor of poorly formed CCC.
Trigger related outcomes of takotsubo syndrome in a cancer population
Authors: Safdar Ayesha , Ahmed Talha , Liu Victor Y. , Addoumieh Antoine , Agha Ali M. , Giza Dana E. , Balanescu Dinu V. , Donisan Teodora , Dayah Tariq , Lopez-Mattei Juan C. , Kim Peter Y. , Hassan Saamir , Karimzad Kaveh , Palaskas Nicolas , Tsai January Y. , Iliescu Gloria D. , Yang Eric H. , Herrmann Joerg , Marmagkiolis Konstantinos , Angelini Paolo , Iliescu Cezar A. 
Published: October 2022

BackgroundTakotsubo syndrome (TTS) occurs more frequently in cancer patients than in the general population, but the effect of specific TTS triggers on outcomes in cancer patients is not well studied.ObjectivesThe study sought to determine whether triggering event (chemotherapy, immune-modulators vs. procedural or emotional stress) modifies outcomes in a cancer patient population with TTS.MethodsAll cancer patients presenting with acute coronary syndrome (ACS) between December 2008 and December 2020 at our institution were enrolled in the catheterization laboratory registry. Demographic and clinical data of the identified patients with TTS were retrospective collected and further classified according to the TTS trigger. The groups were compared with regards to major adverse cardiac events, overall survival and recovery of left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) after TTS presentation.ResultsEighty one of the 373 cancer patients who presented with ACS met the Mayo criteria for TTS. The triggering event was determined to be “cancer specific triggers” (use of chemotherapy in 23, immunomodulators use in 7, and radiation in 4), and “traditional triggers” (medical triggers 22, and procedural 18 and emotional stress in 7). Of the 81 patients, 47 died, all from cancer-related causes (no cardiovascular mortality). Median survival was 11.9 months. Immunomodulator (IM) related TTS and radiation related TTS were associated with higher mortality during the follow-up. Patients with medical triggers showed the least recovery in LVEF and GLS while patients with emotional and chemotherapy triggers, showed the most improvement in LVEF and GLS, respectively.ConclusionCancer patients presenting with ACS picture have a high prevalence of TTS due to presence of traditional and cancer specific triggers. Survival and improvement in left ventricular systolic function seem to be related to the initial trigger for TTS.