bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating and improving learning agility in nursing students
Authors: Aygül Nagihan Sim , Şenyuva Emine 
Published: September 2022

In order to train future nurse leaders and nurses who are successful in their careers, it is predicted in nursing education that the measurement and improvement of learning agility of nurses starting from their student years will make nurses more successful and stronger individually and professionally. The CHOICES scale, which is one of the scales developed to measure learning agility, measures the learning agility of individuals with its 4 sub-dimensions. These four sub-dimensions are; Mental Agility, Agility in Human Relations, Agility in Change and Agility in Creating Results. It is important to use educational models that improve student learning agility in nursing education. Learning agility of nursing students can be improved with educational models like web-based applications and the internet, project-based learning model, flipped classroom model, simulation applications, clinical internship experiences, etc. which facilitate learning based on experiential learning. It is important to provide institutional support for the development of the learning agility of nursing students, to develop the learning agility of the educators separately and to integrate the practices that improve the learning agility for the students into the education system. It is expected that nursing graduates with high learning agility will be able to cope with the difficulties they will encounter in their future business life more easily and more motivated.
Extended English summary is in the end of Full Text PDF (TURKISH) file.

Özet
Hemşirelik eğitiminde geleceğin hemşire liderlerini ve kariyerinde başarılı hemşireleri yetiştirmek için hemşirelerin öğrencilik döneminden başlayarak öğrenme çevikliğini değerlendirme ve geliştirme uygulamaları yapılmasının hemşireleri bireysel ve mesleki profesyonellik bakımından daha başarılı ve güçlü kılacağı öngörülmektedir. Öğrenme çevikliğini ölçmek için geliştirilen ölçeklerin başında gelen CHOICES ölçeği, 4 alt boyutuyla bireylerin öğrenme çevikliğini ölçer. Bahsedilen dört alt boyut; Zihinsel Çeviklik, İnsan İlişkilerinde Çeviklik, Değişimde Çeviklik ve Sonuç Yaratma Çevikliğidir. Hemşirelik eğitiminde öğrencilerin öğrenme çevikliğini geliştirici uygulamaların yapılması önemlidir. Web tabanlı uygulamalar, proje tabanlı öğrenme modeli, ters yüz sınıf modeli, simülasyon uygulamaları, klinik staj deneyimleri vb. öğrenmeyi kolaylaştırıcı ve yaşayarak öğrenmeye dayalı eğitim modelleriyle hemşirelik öğrencilerinin öğrenme çeviklikleri geliştirilebilir. Hemşirelik öğrencilerin öğrenme çevikliklerinin geliştirilmesi için kurumsal desteklerin verilmesi, eğitimcilerin öğrenme çevikliklerinin ayrıca ele alınması ve eğitimcilerin öğrenciler için öğrenme çevikliğini geliştirici uygulamaları eğitim sistemine entegre etmesi önemlidir. Öğrenme çevikliği yüksek mezun hemşirelerin gelecek iş yaşamlarında karşılaşacakları zorluklar ile daha kolay ve güdülenmiş şekilde başa çıkabilmeleri beklenmektedir.
Towards technically controlled bioreactor maturation of tissue-engineered heart valves
Authors: Voß Kirsten , Werner Maximilian P. , Gesenhues Jonas , Kučikas Vytautas , van Zandvoort Marc , Jockenhoevel Stefan , Schmitz-Rode Thomas , Abel Dirk 
Published: September 2022

Abstract
Bioreactors are important tools for the pre-conditioning of tissue-engineered heart valves. The current state of the art mostly provides for timed, physical and biochemical stimulation in the bioreactor systems according to standard protocols (SOP). However, this does not meet to the individual biological variability of living tissue-engineered constructs. To achieve this, it is necessary to implement (i) sensory systems that detect the actual status of the implant and (ii) controllable bioreactor systems that allow patient-individualized pre-conditioning. During the maturation process, a pulsatile transvalvular flow of culture medium is generated within the bioreactor. For the improvement of this conditioning procedure, the relationship between the mechanical and biochemical stimuli and the corresponding tissue response has to be analyzed by performing reproducible and comparable experiments. In this work, a technological framework for maturation experiments of tissue-engineered heart valves in a pulsating bioreactor is introduced. The aim is the development of a bioreactor system that allows for continuous control and documentation of the conditioning process to increase reproducibility and comparability of experiments. This includes hardware components, a communication structure and software including online user communication and supervision. Preliminary experiments were performed with a tissue-engineered heart valve to evaluate the function of the new system. The results of the experiment proof the adequacy of the setup. Consequently, the concept is an important step for further research towards controlled maturation of tissue-engineered heart valves. The integration of molecular and histological sensor systems will be the next important step towards a fully automated, self-controlled preconditioning system.
Effect of La on the catalytic performance of mesoporous Ni/γ-Al2O3 catalysts for dry reforming of methane
Authors: Zhang Dong , Cai Hongyan , Chen Shengming , Gou Zhenqiong , Zhou Guilin 
Published: September 2022

Abstract
Mesoporous Ni/La2O3/γ-Al2O3 catalysts with different La contents (0, 0.5, 1.5, 2.5, 3.5, and 4.5 wt.%) were prepared by the step-by-step impregnation method. The physicochemical properties of the prepared Ni/La2O3/γ-Al2O3 catalysts were characterized by H2-TPR, XRD, BET, O2-TPO, and TG. The effect of La dosage on the catalytic performance of Ni/γ-Al2O3 catalyst for dry reforming of methane was further investigated. The results show that the La content has a significant effect on the reducibility of high-valence Ni species, specific surface area, pore size, and pore volume as well as the catalytic performances. The high-valence Ni species in the NL3.5A catalyst precursor has high reducibility. And the specific surface area, pore size and pore volume of the NL3.5A catalyst are 145.9 m2 g−1, 11.7 nm, and 0.47 cm3 g−1, respectively. The catalytic activity of the series of prepared mesoporous Ni/La2O3/γ-Al2O3 catalysts follows the order: NL3.5A > NL2.5A > NL4.5A > NL1.5A > NL0.5A > NL0A. Namely, the NL3.5A catalyst possesses the best catalytic activity. The CH4 and CO2 conversions of NL3.5A catalyst are 61.6 and 39.1% at 600 °C, respectively. Additionally, it maintains a superior recycle capability for dry reforming of methane reaction because of the high coke resistance compared with the Ni/γ-Al2O3 catalyst.
Faculty supportive behaviors and nursing student mental health: a pilot study
Authors: Stubin Catherine A. , Hargraves Joelle D. 
Published: September 2022

Abstract

Objectives
Relationships between perceived faculty support and prevalence of depression, anxiety, and stress among undergraduate nursing students were explored.

Methods
A mixed method design was used for this descriptive, cross-sectional pilot study. Depression, Anxiety and Stress Scale-21 (DASS-21), Perceived Faculty Support Scale (PFSS), a demographic questionnaire, and open-ended questions were used to collect data.

Results
Nursing students experienced moderate depression and stress, and severe anxiety. Perceived faculty support was moderate. An inverse correlation between select perceived faculty supportive behaviors and depression, anxiety, and stress was evident. Student stressors were related to faculty actions. The theme being attentive to student stress emerged from the qualitative data.

Conclusions
Symptoms of poor mental health among undergraduate nursing students are prevalent and represent a significant public health concern among nursing students. Nurse educators must develop psychological and functional supportive behaviors to promote mental health during nursing students’ transition throughout the nursing program and beyond.
Naturopathic knowledge and approaches to managing endometriosis: a cross-sectional survey of naturopaths with experience in endometriosis care
Authors: Redmond Rebecca , Steel Amie , Wardle Jon , Adams Jon 
Published: September 2022

Abstract

Objectives
Endometriosis is a chronic gynaecological disease with varying symptomatology and negative health outcomes. To ensure the best care for women with endometriosis, women require a multidisciplinary team approach. While some women consult with naturopaths for endometriosis, there has been little research on naturopathic knowledge and the naturopathic approach to endometriosis care.

Methods
This cross-sectional survey recruited naturopaths with experience in menstrual disorders from the Practitioner Research and Collaboration Initiative (PRACI) a Practice-Based Research Network (PBRN). Data collection was conducted via an online self-administrated 62-item questionnaire.

Results
Invitations were sent to 109 naturopaths who self-reported having experience in menstrual disorders, of whom 29 completed the survey (26.6% response rate). Naturopaths perceived endometriosis to be caused by inflammation (n=28, 96.5%) and risk factors associated with familial history (n=26, 89.6%). Many naturopaths aimed at reducing inflammation (n=27, 93.1%) and supporting gastrointestinal function (n=25, 86.2%) in their prescriptions. Naturopaths reported using various healthcare referrals to support women with endometriosis, primarily general practitioners (n=12, 41.3%), acupuncturists/Traditional Chinese Medicine practitioners (n=11, 37.9%), and gynaecologists (n=9, 31%). Naturopaths reported receiving referrals from general practitioners (n=8, 27.5%) and psychologists (n=6, 20.6%).

Conclusions
Naturopathic knowledge and management of endometriosis targets known problematic areas of endometriosis that can have debilitating effects on women’s quality of life. Naturopathic care has the potential to align with important health outcomes for women with endometriosis however, further attention is needed to assess the effectiveness and continue to establish a multidisciplinary approach involving naturopathic care.
Recognizing science fiction
Authors: Miller Zea 
Published: September 2022

AbstractWhereas science fiction has no identity, no necessary conditions, no essence, and no timeless and universal attributes, we should not be able to recognize it. We do. Something must allow it. This article will show how recognition and learning outweigh contingent feature-based academic projects on science fiction as ends, thereby revealing the socio-cognitive frames that buttress such recognition and proposes that we consider semio-cognitive models to refine our understanding of the genre. To that end, this article shows how science fiction is a creative mode recognizable by its prototypes and the theories built thereon. Ultimately, this article promotes a means-based socio-cognitive understanding of science fiction where it is free, in a new way, from retrospective academic projects to define it by ends.
Why Mesolithic Populations Started Eating Crabs on the European Atlantic Façade Only Over the Past 15 Years?
Authors: Dupont Catherine , Gruet Yves 
Published: September 2022

AbstractMesolithic populations from coastal areas are known as hunter-gatherer-fishers. This way of life is visible in the landscape owing to the presence of large accumulations of shells named shell middens. These anthropogenic refuse heaps are composed of high proportions of marine resources, yet studies dedicated to marine components are relatively recent. Efforts have been made to record marine molluscs, but other minorities are still invisible as a result of the small sizes of archaeological remains. Crustaceans are one of these minorities and this article will focus on one of them: crabs. Why are these decapods persistently ignored by most of archaeologists? Is this due to the scant presence of their remains in Mesolithic shell middens? An overview of published data on crabs is presented here for the Mesolithic period on the European Atlantic façade. The proportions of shell middens comprising these crustaceans is evaluated, as well as quantities and identified species. We endeavour to identify the potential impact of excavation methods and sampling on our knowledge of this marine resource. We present the methods developed to extract data from small archaeological crab remains and show how, from a fragment of a crab finger extremity, we can identify the species and estimate the original size of crabs. This methodological challenge has a major impact on our knowledge of past maritime populations.
Die Suche nach den besten Eltern. Eine Dokumentenanalyse zum Wandel des normativen Musters guter Kindheit in der Adoptionsvermittlung.
Authors: König Alexandra , Niederbacher Arne 
Published: September 2022

ZusammenfassungIm vorliegenden Beitrag gehen wir der Frage nach, welches normative Muster guter Elternschaft bzw. Kindheit der Adoptionsvermittlung in Deutschland zugrunde liegt. Gute, gar die ‚besten‘ Eltern für ein Kind zu bestimmen, ist Aufgabe von Adoptionsvermittler*innen. Ihr Auftrag ist (1) die Eignung von (oftmals kinderlosen) Bewerber*innen als Eltern zu prüfen und (2) unter den vielen als ‚geeignet‘ klassifizierten Bewerber*innen die ,passenden‘ für ein spezifisches Kind auszuwählen. Gegenstand unserer an der Grounded Theory orientierten Analyse sind die „Empfehlungen zur Adoptionsvermittlung“, welche seit rund 40 Jahren Vermittler*innen als Orientierung dienen. Sie ermöglichen, die Variabilität des normativen Musters zu erfassen. Erkennbar wird ein Wandel der Bewertungskriterien – vom ‚objektiven‘ Status (etwa Alter, Familienstand) hin zum selbstreflektierten Subjekt – bei gleichzeitiger Konstanz der Orientierung an der Mittelschicht.
HDAC6 Inhibition Reverses Cisplatin-Induced Mechanical Hypersensitivity via Tonic Delta Opioid Receptor Signaling
Authors: Zhang Jixiang , Junigan Jazzmine M. , Trinh Ronnie , Kavelaars Annemieke , Heijnen Cobi J. , Grace Peter M. 
Published: September 2022

Peripheral neuropathic pain induced by the chemotherapeutic cisplatin can persist for months to years after treatment. Histone deacetylase 6 (HDAC6) inhibitors have therapeutic potential for cisplatin-induced neuropathic pain since they persistently reverse mechanical hypersensitivity and spontaneous pain in rodent models. Here, we investigated the mechanisms underlying reversal of mechanical hypersensitivity in male and female mice by a 2 week treatment with an HDAC6 inhibitor, administered 3 d after the last dose of cisplatin. Mechanical hypersensitivity in animals of both sexes treated with the HDAC6 inhibitor was temporarily reinstated by a single injection of the neutral opioid receptor antagonist 6β-naltrexol or the peripherally restricted opioid receptor antagonist naloxone methiodide. These results suggest that tonic peripheral opioid ligand-receptor signaling mediates reversal of cisplatin-induced mechanical hypersensitivity after treatment with an HDAC6 inhibitor. Pointing to a specific role for δ opioid receptors (DORs),Oprd1expression was decreased in DRG neurons following cisplatin administration, but normalized after treatment with an HDAC6 inhibitor. Mechanical hypersensitivity was temporarily reinstated in both sexes by a single injection of the DOR antagonist naltrindole. Consistently, HDAC6 inhibition failed to reverse cisplatin-induced hypersensitivity when DORs were genetically deleted from advillin+neurons. Mechanical hypersensitivity was also temporarily reinstated in both sexes by a single injection of a neutralizing antibody against the DOR ligand met-enkephalin. In conclusion, we reveal that treatment with an HDAC6 inhibitor induces tonic enkephalin-DOR signaling in peripheral sensory neurons to suppress mechanical hypersensitivity.SIGNIFICANCE STATEMENTOver one-fourth of cancer survivors suffer from intractable painful chemotherapy-induced peripheral neuropathy (CIPN), which can last for months to years after treatment ends. HDAC6 inhibition is a novel strategy to reverse CIPN without negatively interfering with tumor growth, but the mechanisms responsible for persistent reversal are not well understood. We built on evidence that the endogenous opioid system contributes to the spontaneous, apparent resolution of pain caused by nerve damage or inflammation, referred to as latent sensitization. We show that blocking the δ opioid receptor or its ligand enkephalin unmasks CIPN in mice treated with an HDAC6 inhibitor (latent sensitization). Our work provides insight into the mechanisms by which treatment with an HDAC6 inhibitor apparently reverses CIPN.
Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel
Authors: Noga Akira , Horii Mao , Goto Yumi , Toyooka Kiminori , Ishikawa Takashi , Hirono Masafumi 
Published: September 2022

AbstractThe conserved nine‐fold structural symmetry of the centriole is thought to be generated by cooperation between two mechanisms, one dependent on and the other independent of the cartwheel, a sub‐centriolar structure consisting of a hub and nine spokes. However, the molecular entity of the cartwheel‐independent mechanism has not been elucidated. Here, using Chlamydomonas reinhardtii mutants, we show that Bld10p/Cep135, a conserved centriolar protein that connects cartwheel spokes and triplet microtubules, plays a central role in this mechanism. Using immunoelectron microscopy, we localized hemagglutinin epitopes attached to distinct regions of Bld10p along two lines that connect adjacent triplets. Consistently, conventional and cryo‐electron microscopy identified crosslinking structures at the same positions. In centrioles formed in the absence of the cartwheel, truncated Bld10p was found to significantly reduce the inter‐triplet distance and frequently form eight‐microtubule centrioles. These results suggest that the newly identified crosslinks are comprised of part of Bld10p/Cep135. We propose that Bld10p determines the inter‐triplet distance in the centriole and thereby regulates the number of triplets in a cartwheel‐independent manner.
The effectiveness of a systematic approach in the complex treatment of congestive prostatitis with chronic pelvic pain syndrome
Authors: Tikhonov I. V. , Tityaev I. I. , Kasyanov D. S. , Chekushin R. H. , Udalov K. V. 
Published: September 2022

Background. Chronic prostatitis/chronic pelvic pain syndrome remains an urgent urological problem due to unsatisfactory treatment results.Aim. To evaluate the effectiveness of complex therapy of chronic prostatitis using special physiotherapeutic methods of exposure.Materials and methods. The clinical study involved 49 patients aged 22 to 47 years with congestive prostatitis. Two groups were made up of them: group 1 (n = 27) received the main treatment complex – prostate massage, magnetic therapy transcranially and perineally, laser therapy transrectally, chloroethyl applications on the Michaelis rhombus; group 2 (n = 22) – prostate massage and longidase in suppositories rectally. Both groups of patients received standard background spa treatment.Results. At the end of the 14th day course of treatment in group 1 the disappearance of chronic pelvic pain syndrome was noted in 65 % of patients (p p p p (p >0.05), in the rest without significant dynamics.Conclusion. Consistent use of a complex of physiotherapeutic procedures with minimal time intervals between them with a directed effect of synergistic factors not only on problem areas, but also on the central mechanisms of autonomic regulation, affecting the emotional sphere of the patient, leads to a decrease in pelvic pain, which is the leading syndrome in the clinical picture of chronic prostatitis.
Application of texture analysis of CT and MR images to determine the histologic grade of hepatocellular cancer and it’s differential diagnosis: a review
Authors: Shantarevich M. Yu. , Karmazanovsky G. G. 
Published: September 2022

In recent years, more foreign publications are devoted to the use of texture analysis or radiomics in solving certain diagnostic problems, including the diagnosis of hepatocellular cancer (HCC). This method of processing medical images allows for a comprehensive assessment of the structure of neoplasms by extracting a large number of quantitative features from medical images.The purpose of the study was to determine the role of texture analysis of CT and MR images in differential diagnosis and determination of the degree of differentiation of HCC based on a review and analysis of the results of publications.We searched for scientific publications in the PubMed information and analytical system for 2015–2021. by keywords: “HCC”, “texture analysis” (texture analysis), “radiomics”, “CT”, “MRI”, “grade”, “differential diagnosis”. After excluding reviews of publications and studying the full text of articles, 21 articles were selected for analysis.Despite the growing number of publications devoted to the successful use of textural analysis of CT and MR images, including non-invasive assessment of the histological grade of HCC and in the differential diagnosis of HCC with hypervascular neoplasms, metastases, regenerative and dysplastic nodes, the use of such type of analysis in routine practice is limited due to the lack of standardized methods for performing texture analysis, which leads to low reproducibility of the results. The parameters of image acquisition and methods of image preprocessing and segmentation affect the reproducibility of the obtained texture features. In addition, the presented studies were performed using different MR sequences and phases of contrast enhancement, as well as different software, which makes it difficult to compare the obtained data.The use of texture analysis certainly demonstrates promising results and requires further investigation to systematize and standardize the obtained data in order to develop an optimal diagnostic model for wide clinical use.