bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of fused and blended fertilizers on maize yield and soil properties
Authors: Maharjan Bijesh , Das Saurav , Shapiro Charles A. 
Published: August 2022

AbstractThe deficiency of secondary and micronutrients negatively affects plant metabolic functions and reduces crop yields. These nutrients are applied in small quantities (<10 kg ha−1) and are physically blended or chemically fused with primary nutrients to enhance uniformity of application. A 3‐yr study (2012–2014) was conducted to evaluate the effects of fall or spring‐applied fertilizer N with or without P and N–P fertilizers containing S and Zn (blended or fused) on soil properties, leaf chlorophyll, and maize (Zea mays L.) yield in Nebraska. Response variables were measured for additional 2 yr (2015–2016; residual years [RYs]). Soil Mehlich‐3 P was low (14 mg kg−1) at the onset of the experiment and adding P increased grain yield by 10% compared with N only treatment in 2013–2015. Grain yields were similar in treatments with S and Zn fused (9.7–12.4 Mg ha−1) or blended (9.7–12.2 Mg ha−1) in all years (2012–2016). A yield benefit of adding S and Zn was recorded only 1 yr (2015: the first RY) (12.3 and 11.6 Mg ha−1 in NP treatments with and without S and Zn). Except for 2012, all fertilized treatments had greater yields than the control in 2013–2016. The 2012 was a dry year, where yield was low across the treatments (1.6–2.1 Mg ha−1) suggesting minimal benefits of adding primary nutrients (N, P), let alone S or Zn, when moisture is limiting. It is warranted that blended and fused fertilizers are evaluated under specific conditions where soils are deficient in constituent nutrients.
Cosmology with Gravitational Waves: A Review
Authors: Mastrogiovanni Simone , Karathanasis Christos , Gair Jonathan , Ashton Gregory , Rinaldi Stefano , Huang Hsiang‐Yu , Dálya Gergely 
Published: August 2022

AbstractStandard sirens have been the central paradigm in gravitational‐wave cosmology so far. From the gravitational wave signature of compact star binaries, it is possible to measure the luminosity distance of the source directly, and if additional information on the source redshift is provided, a measurement of the cosmological expansion can be performed. This review article discusses several methodologies that have been proposed to use gravitational waves for cosmological studies. Methods that use only gravitational‐wave signals and methods that use gravitational waves in conjunction with additional observations such as electromagnetic counterparts and galaxy catalogs will be discussed. The review also discusses the most recent results on gravitational‐wave cosmology, starting from the binary neutron star merger GW170817 and its electromagnetic counterpart and finishing with the population of binary black holes, observed with the third Gravitational‐wave Transient Catalog GWTC–3.
Proton Transfer Pathways in Nitrogenase with and without Dissociated S2B
Authors: Jiang Hao , Svensson Oskar K. G. , Cao Lili , Ryde Ulf 
Published: August 2022

AbstractNitrogenase is the only enzyme that can convert N2 to NH3. Crystallographic structures have indicated that one of the sulfide ligands of the active‐site FeMo cluster, S2B, can be replaced by an inhibitor, like CO and OH−, and it has been suggested that it may be displaced also during the normal reaction. We have investigated possible proton transfer pathways within the FeMo cluster during the conversion of N2H2 to two molecules of NH3, assuming that the protons enter the cluster at the S3B, S4B or S5A sulfide ions and are then transferred to the substrate. We use combined quantum mechanical and molecular mechanical (QM/MM) calculations with the TPSS and B3LYP functionals. The calculations indicate that the barriers for these reactions are reasonable if the S2B ligand remains bound to the cluster, but they become prohibitively high if S2B has dissociated. This suggests that it is unlikely that S2B reversibly dissociates during the normal reaction cycle.
Chiral Nanozymes for Enantioselective Biological Catalysis
Authors: Dong Kai , Xu Chen , Ren Jinsong , Qu Xiaogang 
Published: August 2022

AbstractAs a neat combination of the characteristics of enzymatic activity and nanomaterials, nanozymes have attracted much attention. Although tremendous effort has been devoted to developing nanozymes with high catalytic activity, substrate selectivity is often overlooked in the construction of nanozymes. With their subtly evolving structures, natural enzymes generally possess high selectivity for chiral substrates which play important roles in biosynthesis and biomedical applications. However, the rational construction of nanozymes with high enantioselectivity remains a significant challenge. In this Minireview, we provide an overview of recent advances in strategies for the synthesis of chiral nanozymes and their enantioselective biological catalysis. We further focus on current challenges, potential solutions, and future developing trends of chiral nanozyme‐based enantioselective biological catalysis. There is plenty of room to explore. This Minireview will provide new insights into the development of chiral nanozymes and their applications.
Arene Activation through Iminium Ions: Product Diversity from Intramolecular Photocycloaddition Reactions
Authors: Proessdorf Johanna , Jandl Christian , Pickl Thomas , Bach Thorsten 
Published: August 2022

AbstractWhile 2‐alk‐ω‐enyloxy‐sustituted benzaldehydes do not display any photochemical reactivity at the arene core, the respective iminium perchlorates were found to undergo efficient reactions either upon direct irradiation (λ=366 nm) or under sensitizing conditions (λ=420 nm, 2.5 mol% thioxanthen‐9‐one). Three pathways were found: (a) Most commonly, the reaction led to benzoxacyclic products in which the olefin in the tether underwent a formal, yet unprecedented carboformylation (13 examples, 44–99 % yield). The cascade process occurred with high diastereoselectivity and was found to be stereoconvergent. (b) If a substituent resides in the 3‐position of the benzene ring, a meta photocycloaddition was observed which produced tetracyclic skeletons with five stereogenic centers in excellent regio‐ and diastereoselectivity (2 examples, 58–79 % yield). (c) If the tether was internally substituted at the alkene, an arene photocycloaddition was avoided and an azetidine was formed in an aza Paternò–Büchi reaction (2 examples, 95–98 % yield).
Efficient Gene Silencing in Intact Plant Cells Using siRNA Delivered By Functional Graphene Oxide Nanoparticles
Authors: Li Shuojun , Li Jiaying , Du Moqing , Deng Guiyun , Song Zhiyong , Han Heyou 
Published: August 2022

AbstractDelivery of small interfering RNA (siRNA) to intact plants for gene silencing mainly relies on viral vectors and Agrobacterium‐mediated transformation due to the barrier of intact plant cell wall. Here, we reported that polymer functionalized graphene oxide nanoparticles (GONs) enable siRNA transfer into intact plant cells and bring about efficient gene silencing. We found that sheeted GONs could efficiently load siRNA to form small sized, near‐spheroidal GONs‐siRNA complex, which could be across the cell wall and internalize in the plant cell. The GONs‐siRNA exhibited transient and strong silencing (97.2 % efficiency) in plant tissues at 24 h after treatment and returned to normal level at 5 days after treatment. This method has the obvious advantages of efficient, transient, simple, stability and well biocompatibility, which should greatly stimulate the application of nanomaterials as gene‐engineering tools in plant research.
Study of the impact of epoxidized plant oil phospholipids and hydroxyl radicals on crosslinked epoxy resins
Authors: C. Cabo Maurelio , M. N. Prabhakar , Lee Dong Woo , Song Jung‐il 
Published: August 2022

AbstractThe detrimental environmental consequences of global plastic pollution and the imperative transition, by following the key principles of sustainable development, fully tap the use of renewable feedstocks such as vegetable oil to utilize their functionalities over fossil‐based resources. The current research has developed a novel biobased additive obtained as a byproduct through aromatization of epoxidized corn oil (ECO) using diglycidyl ether aromatic compounds of epoxy resin (EP). The hybrid matrix was made with an ECO content ranging from 10% to 50%. Spectral, elemental, mechanical property, thermal, morphological, and fire hazards analyses revealed that the experimental results of the EPECO50 blend had a 34.94% hydrogen and oxygen added content, resulting in a 62% decrease in flammability when compared to a conventional petroleum‐based mix. Interestingly, the established presence of phospholipids and significant adsorption in the hydroxyl bands support the good intrinsic flame retardancy capabilities of the blend. As a result of the proposed synthesis mechanism, the covalent bonding between epoxy and ECO suggests lower toxicity, as shown by cone calorimetry, with a high reduced yield of CO2(99%) and CO (98%) and, more importantly, the blend is a potential green flame retardant biobased additive. In practice, people die in a fire due to the lack of oxygen and inhalation of harmful smoke; hence, the reduction in total smoke production and CO2and CO emissions clearly helps the smoke suppression of epoxy thermosets when potentially reinforced with biocomposites.
Use of passive acoustic monitoring to document the distribution of the Indo‐Pacific finless porpoise in the south‐east region of Pearl River estuary, China: Implications for conservation and management
Authors: Fang Liang , Wang Xinxing , Li Min , Chen Yujian , Wang Yuezhong , Chen Tao 
Published: August 2022

Abstract

The Pearl River estuary in Guangdong is home to the Indo‐Pacific humpback dolphin (Sousa chinensis) and the Indo‐Pacific finless porpoise (Neophocaena phocaenoides). However, limited data are available for the latter species.
Line‐transect passive acoustic monitoring surveys were conducted to investigate the distribution of the Indo‐Pacific finless porpoise in the Pearl River estuary in the period July to November 2019.
The south‐east region of the Pearl River estuary is an important habitat for the Indo‐Pacific finless porpoise, and more than half of the acoustic detections were within 2 km of islands, concentrated around the uninhabited islands of Soko, Sanmen and Aizhou.
The habitat extents of Indo‐Pacific finless porpoises in the survey areas were estimated as 209.04, 761.81 and 976.41 km2 using 50, 90 and 95% kernel densities, respectively. The 50% kernel density area was mainly around the aforementioned islands and is a priority candidate for protected area status.
This is the first report of the distribution and critical habitat of the finless porpoise in the study area. Given the increasing human development in the Pearl River estuary, the results provide important data to help inform the protection of the habitat of finless porpoise in the context of marine planning and development, and promote the establishment of marine protected areas and stronger fisheries management measures.
A survey of coping strategies and resilience in women victims of domestic violence during the COVID‐19 pandemic in Tehran, 2020
Authors: Rashidi Fakari Farzaneh , Ahmadi Doulabi Mahbobeh , Mokhtaryan‐Gilani Tahereh , Akbarzadeh Baghban Alireza , Hajian Sepideh 
Published: August 2022

AbstractBackgroundDomestic violence against women is a hidden and global epidemic that has many negative effects. The COVID‐19 pandemic, quarantine, and staying at home can lead to violent and domestic violence against women. Due to the importance of the subject, the present study was conducted to investigate the coping strategies and resilience of women victims of domestic violence in the COVID‐19 epidemic in Tehran, 2020.MethodsThe present study is a descriptive‐analytical study on 420 women who suffered domestic violence in Tehran, 2020. Data collection tools included a demographic information form, socioeconomic status questionnaire, WHO standardized domestic violence questionnaire, Connor–Davidson Resilience Scale, and Endler and Parker's coping strategies questionnaire. This study was based on the Internet and online. The research poster, the characteristics of the participants, the voluntary participation in the study, the confidentiality of the information, and the link to the online questionnaire were made public through Internet networks.ResultsThere was no correlation between resilience with general violence (p =.221), types of physical violence (p =.502), psychological violence (p =.178), and sexual violence (p =.386). The results also showed that there was a statistically significant difference between the women who were using or not using a problem‐oriented style with physical violence, using or not using an emotion‐oriented style with physical, psychological, sexual violence, and using or not using an avoidance style with physical violence among the samples (p < .05).ConclusionThe use of coping strategies leads to a reduction in domestic violence against women during the COVID‐19 pandemic. Therefore, designing and implementing training programs to improve coping styles in women can be effective in dealing with such stressful situations and help prevent injuries caused by violence.
Reactive oxygen species‐responsive dual‐targeted nanosystem promoted immunogenic cell death against breast cancer
Authors: Banstola Asmita , Pandit Mahesh , Duwa Ramesh , Chang Jae‐Hoon , Jeong Jee‐Heon , Yook Simmyung 
Published: August 2022

AbstractThe development of an optimal treatment modality to improve the therapeutic outcome of breast cancer patients is still difficult. Poor antigen presentation to T cells is a major challenge in cancer immunotherapy. In this study, a synergistic immunotherapy strategy for breast cancer incorporating immune cell infiltration, immunogenic cell death (ICD), and dendritic cell (DC) maturation through a reactive oxygen species (ROS)‐responsive dual‐targeted smart nanosystem (anti‐PD‐L1‐TKNP) for the simultaneous release of DOX, R848, and MIP‐3α in the tumor microenvironment is reported. Following local injection, anti‐PD‐L1‐DOX‐R848‐MIP‐3α/thioketal nanoparticle (TKNP) converts tumor cells to a vaccine owing to the combinatorial effect of DOX‐induced ICD, R848‐mediated immunostimulatory properties, and MIP‐3α‐induced immune cell recruitment in the tumor microenvironment. Intratumoral injection of anti‐PD‐L1‐DOX‐R848‐MIP‐3α/TKNP caused significant regression of breast cancer. Mechanistic studies reveal that anti‐PD‐L1‐DOX‐R848‐MIP‐3α/TKNP specifically targets tumor tissue, resulting in maximum exposure of calreticulin (CRT) and HMGB1 in tumors, and significantly enhances intratumoral infiltration of CD4+ and CD8+ T cells in tumors. Therefore, a combined strategy using dual‐targeted ROS‐responsive TKNP highlights the significant application of nanoparticles in modulating the tumor microenvironment and could be a clinical treatment strategy for effective breast cancer management.
A hypoxia‐related lncRNA model for prediction of head and neck squamous cell carcinoma prognosis
Authors: Xiang Junwei , He Yaodong , Li Yunshan , Wu Kexuan , Cheng Mengxiang , Wang Yuanyin , Chen Ran 
Published: August 2022

AbstractBackgroundHead and neck squamous cell carcinoma (HNSCC) is one of the most common and highly heterogeneous malignancies worldwide. Increasing studies have proven that hypoxia and related long non‐coding RNA (lncRNA) are involved in the occurrence and prognosis of HNSCC. The goal of this work is to construct a risk assessment model using hypoxia‐related lncRNAs (hrlncRNAs) for HNSCC prognosis prediction and personalized treatment.MethodsTranscriptome expression matrix, clinical follow‐up data, and somatic mutation data of HNSCC patients were obtained from The Cancer Genome Atlas (TCGA). We used co‐expression analysis to identify hrlncRNAs, then screened for differentially expressed lncRNAs (DEhrlncRNAs), and paired these DEhrlncRNAs. The risk model was established through univariate, least absolute shrinkage and selection operator (LASSO), and stepwise multivariate Cox regression. Finally, we assessed the model from multiple perspectives of tumor mutation burden (TMB), tumor immune infiltration, chemotherapeutic sensitivity, immune checkpoint inhibitor (ICI), and functional enrichment.ResultsThe risk assessment model included 14 hrlncRNA pairs. The risk score was observed to be a reliable prognostic factor. The high‐risk patients had an unfavorable prognosis and significant differences from the low‐risk group in TMB and tumor immune infiltration. In the high‐risk patients, the common immune checkpoints were down‐regulated, including CTLA4 and PDCD1, and the sensibility to paclitaxel and docetaxel was higher. The functional enrichment analysis suggested that the low‐risk group was accompanied by activated immune function.ConclusionsThe risk assessment model of 14‐hrlncRNA‐pairs demonstrated a promising prognostic prediction for HNSCC patients and can guide personalized clinical treatment.
Unusual presentation in amyloidosis
Authors: Mahmoud Ines , Rouached Leila , Chammakhi Meriem , Ben Tekaya Aicha , Bouden Selma , Ben Miled Aycha , Tekaya Rawdha , Saidane Olfa , Abdelmoula Leila 
Published: August 2022

AbstractWe report a case of osteolytic polyarthritis and atlanto‐axial lesion revealing multiple myeloma‐associated amyloid arthropathy in a 56‐year‐old man. Only histological exam of the salivary gland biopsy demonstrating the presence of amyloid deposits stained with congo red could confirm the diagnosis.
Early onset of scleromyxedema Arndt‐Gottron associated with a monoclonal gammapathy: Successful treatment with intravenous immunoglobulins
Authors: Kefi Asma , Jaziri Fatima , Ben Abdelghani Khaoula , Turki Sami 
Published: August 2022

AbstractArndt‐Gottron (S‐AG) syndrome or scleromyxedema is a scarce disease characterized by a generalized papular and sclerodermoid eruption and systemic manifestations that can lead to significant morbid‐mortality. Interesting, S‐AG can be associated with a paraprotein. We report an exceptional scleromyxedema case associated with a benign monoclonal gammapathy in an old woman.
Injectable soft tissue filler infection with a similar appearance to an odontogenic abscess
Authors: Rezaei Avval Arvin , Hamidzadeh Fatemeh , Sarraf Pegah , Khoshkhounejad Mehrfam 
Published: August 2022

AbstractInfection of an injectable soft tissue filler may involve fascial spaces and appears similar to an odontogenic abscess. This case report addresses a 32‐year‐old female patient with facial swelling who was referred to the department of endodontics for the treatment of a suspected odontogenic infection.
Gastric glomus tumor presenting with massive upper GI bleeding: A challenging to diagnose and treat tumor
Authors: Ayash Ahmad , Elkomy Nasrein , Al‐Mohannadi Muneera Jassim , Al Kaabi Saad Rashid , Petkar Mahir 
Published: August 2022

AbstractGlomus tumors are infrequent benign tumors that originate from the glomus body and can be found anywhere in the body including the gastrointestinal tract. It is rare that gastric glomus tumors present with life‐threatening upper GI bleeding. Diagnosis of gastric glomus tumors poses a challenge due to overlapping endoscopic and endosonographic features with other gastric subepithelial lesions, and the final diagnosis may not be clear until after surgical resection and pathological examination. We report the case of a 61‐year‐old patient who presented with massive upper GI bleeding secondary to an ulcerated gastric glomus tumor that was eventually treated with surgical wedge resection of the tumor.
Adenosquamous carcinoma of the pancreas: A rare and aggressive variant of pancreatic cancer
Authors: Limaiem Faten , Hajri Mohamed , Ben Farhat Leila 
Published: August 2022

AbstractAdenosquamous carcinoma of the pancreas is a rare and aggressive histological subtype of pancreatic adenocarcinoma, which accounts for 1% to 4% of the exocrine pancreatic malignancies. Its diagnosis relies on histological examination revealing the coexistence of ductal adenocarcinoma and squamous carcinoma with the latter representing ≥30% of the tumor.
Dominant omodysplasia—A sporadic case—A new case report and review of the literature
Authors: Arabzadeh Aidin , Baghianimoghadam Behnam , Nabian Mohammad Hossein , Fallah Yousef , Ebrahimnasab Mohammad Mehdi 
Published: August 2022

AbstractOmodysplasia is an extremely rare skeletal dysplasia. Since introducing this phenotype as a new syndrome, ten cases of the autosomal dominant type of this disease have been reported. Here, we present a new patient and review published articles in this field to provide a clinical diagnostic criterion.
Harnessing natural killer cells to develop next‐generation cellular immunotherapy
Authors: Liu Siyao , Nguyen Kaycee , Park Dongyong , Wong Nelson , Wang Anson , Zhou Yubin 
Published: August 2022

AbstractCellular immunotherapy harnesses the body's own immune system to fight cancer by using engineered T cells, macrophages, or natural killer (NK) cells. Compared to chimeric antigen receptor T (CAR‐T) cells that are commonly used to treat hematological malignancies, CAR‐NK cells have shown remarkable therapeutic effectiveness while exhibiting enhanced safety, reduced risk of graft‐versus‐host disease, fewer side effects, and amplified antitumor efficacy. Preclinical trials have unveiled the high potential of adoptive CAR‐NK cell therapy to curtail or even eliminate both hematological malignancies and solid tumors in animal models. We brought forth herein the design principle of CAR‐NK cells, highlighted the latest progress in the preclinical testing and clinical trials of CAR‐NK cells, briefly delved into discussed major roadblocks in CAR‐NK therapy, and discussed potential solutions to surmount these challenges. Given the accelerated progress in both basic and translational studies on immune cell engineering, CAR‐NK cell therapy promises to become a serious contender and important addition to the next‐generation cell‐based immunotherapy.
Deactivation Mechanism of an Ionic Liquid Catalyst in Transesterification to Dimethyl Carbonate
Authors: Ma Junteng , Shen Weihua , Wei Wenxuan , Fang Yunjin 
Published: August 2022

AbstractThe catalytic activity of an ionic liquid catalyst decreased during the transesterification of propylene carbonate (PC) with methanol to dimethyl carbonate (DMC). The interaction between the strong basic sites of ionic liquid catalyst and carbonyl compounds of PC and/or DMC was considered to attribute to this deactivation. The presence of H2O accelerated this process by the formation of OH–. The strong basic ionic liquid reacted with the trace amount of H2O in the reaction system to generate OH–, which then reacted with the carbonyl structure in PC and/or DMC to form the inactive compound HCO3–, resulting in the deactivation of the ionic liquid catalyst. A plausible mechanism was proposed for the deactivation of the ionic liquid catalyst in this reaction.
Carbon Shell‐Encapsulated Metal Alloy Catalysts with Pt‐Rich Surfaces for Selective Hydrogen Oxidation Reaction
Authors: Ko Keonwoo , Min Jiho , Kim Yunjin , Hong Min Woo , Jeffery A. Anto , Chougule Sourabh S. , Bok Yi Kwang , Jung Namgee 
Published: August 2022

AbstractInvited for this issue's Front Cover are the groups of Kwang Bok Yi and Namgee Jung from Chungnam National University (South Korea). The Front Cover shows the catalyst structure that blocks O2 gas (red circles) penetration and selectively permeates H2 gas (blue circles) via the molecular sieve effect by the carbon shell coated on the metal surface to suppress reverse current flow under shut‐down/start‐up conditions during fuel cell operation. Read the full text of the Research Article at 10.1002/celc.202200342.