bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency of Different Histological Types of Breast Tumors Reported at DHQ Hospital Abbottabad Pakistan
Authors: Ayaz Attiya , Muhammad Taj , Ammir Kishwar , Farzana Rukia , Memon Gulshan Ali , Mallah Farzana , Ahmer Arslan 
Published: March 2022

Introduction: The carcinoma of Breast is the most common form of cancer and thus the major source of carcinoma mortality globally.
Objective: The goal of this study was to determine the most prevalent etiology of a fresh breast tumor as well as the occurrence of different types in subjects who presented with breast tumors at DHQ Hospital Abbottabad KPK Pakistan.
Methodology: The research was carried out at the DHQ Hospital Abbottabad. The research was performed from 20 February 2018 to 20 February 2020. It is a cross-sectional study and consisted of 200 female patients.
Results: The age of the patients ranged from between 30 years to 65 years, 47.6800 mean and 9.22187 SD, BMI minimum20.20 and maximum33.40 mean 24.7615 and 2.97309 SD. Regarding the symptom analysis breast pain was common feature in benign and malignant disorders. For diagnostic purpose here the FNAC and Biopsy incisional, trucut and excisions were carried out. FNAC was done in 66.5% incisional 5.5%, trucut 10.5% and excisions 17.5% cases. Regarding the different ratios of benign and malignant lesions there were 64.0% benign and 36% were malignant lesions.
Conclusion: Early identification and prompt treatment as per type to define the managing concerns for subjects with a fresh breast lump may improve in terms of morbidity and mortality.
Pan Facial Trauma Fracture Management: Case Report & Literature Review
Authors: Vijapur Manjunath , Ukken Nidhi Jenson , Kattimani Vasanth , Kumar D. Prasanna , Pasha Aysha Kaleem , Anuradha . 
Published: March 2022

Pan facial fractures involve the mandible, maxilla, and zygomatic complex at the same time, and are frequently associated with NOE and frontal bone fractures. Reconstruction of multiple facial fractures including the top and lower face should be handled as a jigsaw. To accomplish this, two common management sequences for Pan facial fractures have been proposed: "Bottom up and inside out" and "Top down and outside in." There are more sequences, but these two major ways are the most common. The proximity of the maxillofacial region to important features or senses such as vision (diplopia), olfaction, respiration (airway management), chewing or mastication (occlusion), deglutition, and aesthetics makes the scenario a little more complex for the surgeon operating in this region than in any other part of the body.
It's difficult to stick to a tried-and-true procedure for treating pan face fractures. Despite rigorous therapy, most patients with pan facial trauma may have some residual deformity, which may necessitate more surgery in the future. The care and easy procedures utilized to decrease and fix a case of pan facial trauma in a 26-year-old are described in this article.
Autonomous Reconstitution of Fractured Hybrid Perovskite Single Crystals
Authors: Al‐Handawi Marieh B. , Dushaq Ghada , Commins Patrick , Karothu Durga Prasad , Rasras Mahmoud , Catalano Luca , Naumov Panče 
Published: March 2022

AbstractThe outstanding performance and facile processability turn hybrid organic–inorganic perovskites into one of the most sought‐after classes of semiconducting materials for optoelectronics. Yet, their translation into real‐world applications necessitates that challenges with their chemical stability and poor mechanical robustness are first addressed. Here, centimeter‐size single crystals of methylammoniumlead(II) iodide (MAPbI3) are reported to be capable of autonomous self‐healing under minimal compression at ambient temperature. When crystals are halved and the fragments are brought in contact, they can readily self‐repair as a result of a liquid‐like behavior of their lattice at the contact surface, which leads to a remarkable healing with an efficiency of up to 82%. The successful reconstitution of the broken single crystals is reflected in recuperation of their optoelectronic properties. Testing of the healed crystals as photodetectors shows an impressive 74% recovery of the generated photocurrent relative to pristine crystals. This self‐healing capability of MAPbI3 single crystals is an efficient strategy to overcome the poor mechanical properties and low wear resistance of these materials, and paves the way for durable and stable optoelectronic devices based on single crystals of hybrid perovskites.
circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity
Authors: Chen Zhenzhen , He Luyun , Zhao Liangbo , Zhang Guangtan , Wang Zhiwei , Zhu Pingping , Liu Benyu 
Published: March 2022

AbstractColorectal cancer (CRC) is one of the most common tumors around the world. Circular RNA is widely involved in tumor progression via unclear mechanisms. Here, circREEP3 is found to be upregulated in CRC tissues. circREEP3 upregulation predicts poor patient survival. circREEP3 knockout suppresses CRC tumorigenesis and metastasis, and impairs stem cell‐like phenotype. Mechanistically, circREEP3 recruits the chromatin remodeling protein CHD7 to FKBP10 promoter and activates its transcription. Moreover, circREEP3 restricts RIG‐1‐dependent antitumor immunity. FKBP10 is highly expressed in CRC tissues and associated with poor prognosis. FKBP10 ectopic expression partially rescues the potential of proliferation and metastasis in circREEP3‐deficient CRC cells. Thus, the findings support circREEP3‐FKBP10 axis drives CRC progression and may be a critical prognostic marker.
Directly Printed Embedded Metal Mesh for Flexible Transparent Electrode via Liquid Substrate Electric‐Field‐Driven Jet
Authors: Li Zhenghao , Li Hongke , Zhu Xiaoyang , Peng Zilong , Zhang Guangming , Yang Jianjun , Wang Fei , Zhang Yuan‐Fang , Sun Luanfa , Wang Rui , Zhang Jinbao , Yang Zhongming , Yi Hao , Lan Hongbo 
Published: March 2022

AbstractFlexible transparent electrodes (FTEs) with embedded metal meshes play an indispensable role in many optoelectronic devices due to their excellent mechanical stability and environmental adaptability. However, low‐cost, simple, efficient, and environmental friendly integrated manufacturing of high‐performance embedded metal meshes remains a huge challenge. Here, a facile and novel fabrication method is proposed for FTEs with an embedded metal mesh via liquid substrateelectric‐field‐driven microscale 3D printing process. This direct printing strategy avoids tedious processes and offers low‐cost and high‐volume production, enabling the fabrication of high‐resolution, high‐aspect ratio embedded metal meshes without sacrificing transparency. The final manufactured FTEs with 80 mm × 80 mm embedded metal mesh offers excellent optoelectronic performance with a sheet resistance (Rs) of 6 Ω sq−1 and a transmittance (T) of 85.79%. The embedded metal structure still has excellent mechanical stability and good environmental suitability under different harsh working conditions. The practical feasibility of the FTEs is successfully demonstrated with a thermally driven 4D printing structure and a resistive transparent strain sensor. This method can be used to manufacture large areas with facile, high‐efficiency, low‐cost, and high‐performance FTEs.
Early termination of pivotal trials in Alzheimer's disease—Preserving optimal value for participants and science
Authors: Gietl Anton F. , Frisoni Giovanni B. 
Published: February 2022

AbstractParticipants in Alzheimer's disease late‐phase clinical trials are frequently confronted with a situation of early termination. We discuss measures to protect the perceived value of study participation and to maximize the scientific value under such circumstances. A communication strategy should ensure that trial participants maintain a positive relationship with the research team and have their informational needs optimally met. Measures to maximize the scientific value may include data/sample sharing, strategies for personalized medicine, as well as scientific follow‐up. Critical for the success of such a concept are networks of excellence, extending models of existing initiatives like Global Alzheimer's Platform Foundation Network (GAP‐Net).These networks could fundamentally strengthen the role of clinical investigators if they decide on their involvement in trials based upon their estimation of the scientific value and benefit for the participants, actively contribute to scientific analyses, and mediate optimal communication among the relevant trial stakeholders.
Cerebral vasospasm syndromes and postpartum eclampsia associated with post‐dural puncture headache
Authors: Santos D. J. R. R. , Estevens T. M. R. N. , Farinha R. F. O. L. 
Published: March 2022

SummaryHeadache is common in the puerperium, with a wide variety of underlying aetiologies. We describe a unique case of postpartum headache after accidental dural puncture with a Tuohy needle in a previously healthy woman during a combined spinal‐epidural for labour analgesia. Initially, a post‐dural puncture headache was diagnosed. Eclampsia was subsequently suspected after the development of complex partial seizures and proteinuria 5 days postpartum. After neurological examination and neuroimaging, however, the diagnoses of reversible cerebral vasoconstriction syndrome and posterior reversible encephalopathy syndrome were confirmed. We hypothesise that accidental dural puncture which resulted in post‐dural puncture headache may have delayed the diagnosis of other headache aetiologies and may have acted as a trigger for the development of cerebral vasospasm syndromes. This case demonstrates the importance of a careful assessment of postpartum headaches and the need for a high degree of diagnostic suspicion in cases of refractory post‐dural puncture headache. In these cases, neurological referral and neuroimaging evaluation should be considered. We highlight the importance of multidisciplinary team including anaesthetists, obstetricians and other clinicians.
Effect of G‐quadruplex loop mutations on the G‐quadruplex formation, protein binding and transcription of BmPOUM2 in Bombyx mori
Authors: Chen Yanfei , Niu Kangkang , Song Qisheng , Feng Qili 
Published: February 2022

AbstractA G‐quadruplex (G4) was identified in the promoter of transcription factor BmPOUM2 in Bombyx mori. This G4 structure contains three loops and is bound by transcription factor BmLARK, facilitating the transcription of BmPOUM2. However, the relationship between the structure and function of the BmPOUM2 G4 remains to be clarified. In this study, loop mutants of the BmPOUM2 G4 structure were generated to study the function of the structure in transcription regulation. The results revealed that mutations of Loops A and B could not completely suppress G4 formation, but affected the binding of the G4 structure with BmLARK and the promoter activity. The mutation (C‐to‐T) of the one‐nucleotide‐loop, Loop C, enhanced the G4 formation, its binding with BmLARK and the transcription activity of the BmPOUM2 promoter. It is speculated that the binding site of BmLARK probably is on the G‐quartet planes, rather than on the loops, which may assist the maintenance and modification of the G4 structure and its protein binding activity.
System identification using NARX and centrifugal compressor control through the intelligent, active method—Case study: K‐250 centrifugal compressor
Authors: Khosravi Adel , Chatraei Abbas , Shahgholian Ghazanfar , Kargar Seyed Mohamad 
Published: March 2022

AbstractSurge and constant pressure are some of the most critical issues in compressor control. In this paper, the problem of the surge and constant pressure in the presence of environmental disturbances is solved. Proposed design for control system based on proportional–integral controllers, adaptive neuro‐fuzzy inference system (FIS), and particle swarm optimized neural fuzzy and for modeling neural network strategy fuzzy nonlinear automatic regression with external input is used. Based on this, for modeling, practical and real data are extracted from the K‐250 compressor of Isfahan Steel Company. In the adaptive neuro‐fuzzy inference system–particle swarm optimization (ANFIS‐PSO) controller, the control algorithm is made of the third FIS structure based on the fuzzy center clustering method and trained based optimization on the particle swarm optimization (PSO) algorithm, which has three layers, two inputs, and a single output. The proposed control algorithm has finally been able to bring the compressor to the desired pressure, and when the compressor enters the surge area, the controller has been able to remove the compressor from this area without damaging the compressor. Finally, the proposed control system's capability and effectiveness are shown through simulation in MATLAB software and practical implementation.
Adoption of biofuels for marine shipping decarbonization: A long‐term price and scalability assessment
Authors: Tan Eric C. D. , Harris Kylee , Tifft Stephen M. , Steward Darlene , Kinchin Christopher , Thompson Thomas N. 
Published: February 2022

AbstractThis study assessed the long‐term annual biofuel production capacity potential and price in the United States and shed light on the prospect of biofuel adoption for marine propulsion. A linear programming model was developed to assist the projections and provide insightful analyses. The projected long‐term (2040) maximum annual capacity of biofuels in the United States is 245 million metric tons (Mt) or 65 billion gallons of heavy fuel oil gallon equivalent (HFOGE) when based on the median feedstock availability. Between 2022 (near‐term) and 2040, the potential biofuel capacity increases by over 40%, attributed to increased feedstock availability. At a price range up to $500/t, biodiesel is the main product, and the annual capacity (12 Mt) is limited to feedstock availability constraints. Biodiesel and corn ethanol are the main biofuels at a price range up to $750/t. At a higher price point (above $750/t), the biofuel types and annual capacities increase substantially (218 Mt per year). Biofuels above this price include gasoline‐, jet‐, and diesel‐range blendstocks, as well as bio‐methanol, bio‐propane, and biogas. This study concludes that the US domestic feedstock availability coupled with advanced conversion technologies can produce substantial amounts of biofuels to achieve a critical mass and be impactful as alternative marine fuels. There is also a need to improve the biofuel price for marine shipping adoption. Policies and economic incentives that provide temporary financial support would help facilitate maritime biofuel adoption. © 2022 Alliance for Sustainable Energy, LLC. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd.
PolyE‐IL: A polymeric Brønsted acid ionic liquid catalyst for catalytic thermo liquefaction of sugarcane bagasse into carboxylic acids
Authors: Ukarde Tejas M. , Pawar Hitesh S. 
Published: February 2022

AbstractThe present study demonstrates a catalytic thermo liquefaction (CTL) process for the liquefaction of sugarcane bagasse into carboxylic acids using recyclable polymeric Brønsted acid ionic liquids (PolyE‐ILs) catalyst. A series of acid catalysts such as mineral acids, imidazole‐based ionic liquid and PolyE‐ILs with variable counter ions were tested. Of the tested catalysts, [PEI]+[HSO4]− resulted in 51.84% levulinic acid, 53.07% formic acid and 100% acetic acid yields compared with their theoretical maximum with 81.40% feedstock conversion at 210 °C for 120 min. Under 10 bar N2 pressure. The carbon‐enriched side products (CTL‐oil), catalyst and carboxylic acids were separated by integrating the adsorption and membrane separation process with >98% efficiency. The CTL‐oil with calorific a value of 25–26 MJ/kg can be explored for further energy and fuel applications. Thus, the use of a robust and recyclable catalyst at moderate operating conditions provides an efficient pathway for the valorization of sugarcane bagasse into carboxylic acids and CTL‐oil. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd
Co‐pyrolysis of a coal/biomass blend into biofuel: optimization of operational parameters using central composite design
Authors: Onay Özlem 
Published: February 2022

AbstractResearchers are attempting to replace fossil and petro‐based fuels with renewable and green fuels. Knowing the optimum values of pyrolysis parameters during the production of biofuel from biomass/coal blends is important to obtain biofuel in the desired yield and quality. In this study, a central composite design was used in order to optimize pyrolysis parameters to obtain biofuel from the co‐pyrolysis of a coal (lignite)/biomass (pistachio seeds) mixture in a well‐swept resistance fixed bed reactor. Knowing the optimum values ​​of different parameters affecting the biofuel yield and quality is very important in terms of the most efficient conditions and the economical production of energy. The effects of some operational parameters, like final temperature (factor A), heating rate (factor B) and percentage of lignite (factor C), were optimized through the central composite design method, and their behaviors were analyzed using analysis of variance. While the linear and quadratic effects of the final temperature and heating rate on the biofuel yield were significant, only the linear effect of the percentage of lignite was found to be important; on the other hand, the effects of the binary interaction between the factors were found to be insignificant. A quadratic equation was proposed to predict the behavior of the process under various conditions with an R2 of 98.19. The best condition was predicted at a final temperature of 595 °C, a heating rate of 458 °C/min and a percentage lignite of 16.7% with maximum biofuel yield of 61.23%. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd
Extent of coronary atherosclerosis and ischemic myocardium foment sudden cardiac death
Authors: Goldstein James A. , Mehta Nishaki K. 
Published: March 2022

Key Points

Extent and severity of CAD burden and magnitude of ischemic myocardium key provocative factors for SCD.
STEMI due to thrombosis of proximal LAD unstable plaque poses greatest SCD risk.
Thrombus burden per se resulting in total occlusion contributes to arrhythmogenesis, explaining in part rarity of SCD in Unstable angina and NSTEMI.
Crystallization and Phase Transition of 1‐Butene Copolymers with Distinct Cyclic Co‐Units
Authors: Liu Long , Lou Yahui , Qv Chunjing , Ma Zhe , Li Yuesheng 
Published: February 2022

Comprehensive SummaryThe dimethylpyridylamidohafnium catalyst was used to synthesize 1‐butene/cyclohexene and 1‐butene/vinylcyclohexane random copolymers, which have extra six‐membered cyclic co‐units in main chain and side chain, respectively. For the obtained copolymers of different incorporations, the crystallization from amorphous melt and the solid phase transition from tetragonal to trigonal phases were investigated with differential scanning calorimetry. Both of the incorporated cyclic co‐units decrease the crystallization kinetics, but the presence of cyclohexene keeps the melting temperature of copolymers constant. Interestingly, the strong memory effect of crystallization can appear at the elevated temperature even above the equilibrium melting temperature, as the content of co‐units was increased. The 1‐butene/vinylcyclohexane copolymer with 1.52 mol% co‐units exhibits a rather strong memory effect with the broad Domain IIa width of 43°C and the crystallization temperature raising of 24°C. Furthermore, the transition of tetragonal phase into trigonal phase was also explored for different co‐units and incorporations. It was found that both of the cyclohexene co‐units and vinylcyclohexane co‐units effectively slow down the kinetics of phase transition. However, the vinylcyclohexane co‐units have a much higher efficiency in suppressing phase transition than the cyclohexene co‐units, where 0.53 mol% vinylcyclohexane can completely stop phase transition within 1320 h. Considering the fact that copolymers with vinylcyclohexane co‐units actually have lower glass transition temperatures, it was indicated that the suppression of phase transition is also largely influenced by the steric co‐units in the side chain for the helical and positional adjustments, not only by the segmental mobility.
Prognostic role of low muscle mass and strength in palliative care patients with incurable cancer: a retrospective study
Authors: Mori Naoharu , Maeda Keisuke , Yamanaka Yousuke , Matsuyama Remi , Nonogaki Tomoyuki , Kato Ryoko , Ishida Yuria , Shimizu Akio , Ueshima Junko 
Published: March 2022

AbstractBackgroundWasting of muscle mass and decreasing strength have been proven to be negative prognostic indicators for patients with cancer receiving anticancer treatment. However, little is known about their role in palliative care patients. The objective of this study was to evaluate the prognostic significance of low muscle mass and strength in predicting survival among patients in palliative care.MethodsWe retrospectively examined the association between muscle mass and strength and prognosis in patients with incurable solid cancer who were supported by a palliative care team at a university hospital. Psoas muscle index (PMI) at the level of the fourth lumbar vertebra was employed as the muscle mass index. Pinch grip strength (PGS) was used as the muscle strength index. Cox proportional hazards analysis was performed to evaluate the factors independently associated with overall survival.ResultsA total of 78 patients were included in this study (35 male, median age 67 years). Median survival was 87.5 (95% confidence interval 50–124) days. After adjustment for age, sex, albumin, oedema, and performance status as potential confounders, loss of PMI (hazard ratio 0.998, 95% confidence interval 0.996–0.999; P = 0.003) and PGS (hazard ratio 0.73, 95% confidence interval 0.55–0.97; P = 0.030) independently predicted the overall survival.ConclusionsLow muscle mass and strength are independent predictors of survival in patients with incurable solid cancer receiving palliative care. PMI and PGS measurements may help to better assess the prognosis of patients in palliative care.