bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogeological feasibility of mine water deep geological storage in Baotashan coarse sandstone: A case study in Ordos Basin
Authors: Chen Ge , Sun Yajun , Xu Zhimin , Li Xin 
Published: November 2022

AbstractFor the sake of mine water drainage and sustainable groundwater protection, the new approach of mine water deep geological storage (MWDGS) is highly necessary to save water resources in the semi‐arid region of China. However, up to now, little academic research has been done on mine water geological storage. Given this situation, the hydrogeological feasibility of MWDGS was explored in Baotashan coarse sandstone (BCS) of Jurassic measure in Ordos Basin. The results show that the white‐gray BCS with a fragile skeleton of quartz (41.4%), feldspar (21.1%), and clay minerals (16.4%) provides the potential variable‐void for mine water; and its hydro‐chemical type of BCS aquifer is CO3‐Na and Cl‐Na. As the burial depth increases, the strong alkaline groundwater is in stagnant and poor recharge‐runoff‐discharge condition. The lab test shows that the pores whose diameter is over 10 μm could be treated as the main storage of mine water; and the effective porosity varies from 1.36% to 3.46%. When mine water is injected, the strong hydrodynamics of mine water storage would change the permeability significantly and about 0.201% soluble solids would be dissolved. Partial clay minerals obstruct the pores and induce the saturated phase of high permeability to evolve into steady phase of lower permeability. Under the condition of nonhydraulic fracturing during continuous storage, the heterogeneous anisotropic medium obtained by Transition PRObability GeoStatistics (TPROGS) shows that the capacity of BCS aquifer is 0.455 to 1.226 Mm3 for 1 km2 in the study area. The simulation shows that the groundwater mound in well‐scale and mine‐scale would be formed. The groundwater quality characteristics of “Three Zone” would occur around and gradually drop to approximate the original brine within 10 years. The hydrogeological feasibility reveals that this approach is useful for the well design and groundwater environment management during the mine water deep geological storage project in the Ordos basin.
Electrochemical Method for G‐quartet RNA Detection of COVID‐19 Based on Cyclic Ferrocenylnaphthalene Diimide
Authors: Kaneyoshi Shuma , Murakami Shun , Ikeda Takumi , Fujimoto Kazuhisa , Fujii Satoshi , Sato Shinobu , Takenaka Shigeori 
Published: November 2022

AbstractTo develop an electrochemical detection method for COVID‐19, we have investigated the interaction between RG‐1, a characteristic parallel four‐strand RNA component of the COVID‐19 genome, and cyclic ferrocenylnaphthalene diimides carrying different linker lengths 1 and 2, which bind to RG‐1 more strongly than cyclic naphthalene diimide 3 that lacks a ferrocene moiety. In particular, the binding affinity of 1 having short one showed the highest binding affinity to RG‐1, and the redox current of 1 increased in the presence of RG‐1 using a glassy carbon electrode. This increasing current of 1 in the presence of c‐myc as a parallel G4 DNA or single‐stranded RNA was lower than that in the presence of RG‐1. Several RG‐1 was electrochemically detected at the nanomolar level by 1.
Nomograms as a graphical model to predict biogas at municipal wastewater treatment plant using fuzzy indices
Authors: Anaokar Guruprasad S. , Khambete Anjali K. , Christian Robin A. 
Published: November 2022

AbstractThe strength of municipal wastewater and sludge considering their potential for biogasification can be expressed in terms of multiple parameter comprehensive indices (MPCI), namely, Wastewater Comprehensive Index (WWCI) and Sludge Comprehensive Index (SCI), respectively. Both of these indices can be calculated using fuzzy multiple criteria decisions making (FMCDM). Simple linear equations are established to express the relation between these indices, suspended solids concentration and biogas. The linear equation is developed to predict biogas from multiple parameter comprehensive indices, which indicate the linear relation between strength of wastewater, sludge and biogas. Nomogram was developed to get immediate quantification of biogas by linear scaling of suspended solid concentration and multiple parameter comprehensive indices (MPCI). Using a linear equation obtained from regression analysis; a suitable scale was developed to construct the nomogram. The biogas was found 96% precise with reference to measured one when estimated using nomograms. A single parameter, that is, suspended solids concentration will be monitored at municipal wastewater treatment plant, by digital device; to save chemicals, time, power and human resource. While taking efforts toward smart cities; digitalization and resource conservation will be creditable.
Evaluation of patient transport service in hospitals using process mining methods: Patients' perspective
Authors: Kropp Tobias , Faeghi Shiva , Lennerts Kunibert 
Published: November 2022

AbstractDesigning healthcare facilities and their processes is a complex task which influences the quality and efficiency of healthcare services. The ongoing demand for healthcare services and cost burdens necessitate the application of analytical methods to enhance the overall service efficiency in hospitals. However, the variability in healthcare processes makes it highly complicated to accomplish this aim. This study addresses the complexity in the patient transport service process at a German hospital, and proposes a method based on process mining to obtain a holistic approach to recognise bottlenecks and main reasons for delays and resulting high costs associated with idle resources. To this aim, the event log data from the patient transport software system is collected and processed to discover the sequences and the timeline of the activities for the different cases of the transport process. The comparison between the actual and planned processes from the data set of the year 2020 shows that, for example, around 36% of the cases were 10 or more minutes delayed. To find delay issues in the process flow and their root causes the data traces of certain routes are intensively assessed. Additionally, the compliance with the predefined Key Performance Indicators concerning travel time and delay thresholds for individual cases was investigated. The efficiency of assignment of the transport requests to the transportation staff are also evaluated which gives useful understanding regarding staffing potential improvements. The research shows that process mining is an efficient method to provide comprehensive knowledge through process models that serve as Interactive Process Indicators and to extract significant transport pathways. It also suggests a more efficient patient transport concept and provides the decision makers with useful managerial insights to come up with efficient patient‐centred analysis of transportation services through data from supporting information systems.
Strengthening rural surgery in the Philippines: Essential in achieving universal health care
Authors: Viray Brent A. G. , Arcilla Crisostomo E. , Perez Anthony R. , Marfori Jose R. , De Leon Michael , Ahmadi Attaullah , Lucero‐Prisno Don E. 
Published: November 2022

AbstractThe Lancet Commission on Global Surgery (LCoGS) launched Global Surgery 2030 to address the surgical services inequities with a bias toward low‐income and middle‐income countries like the Philippines. The same inequity is observed particularly when it comes to the urban‐rural divide. With more than half of the population living in rural areas, access to surgery becomes a major challenge that further impedes the much‐needed health of an economically productive workforce. The Universal Health Care [UHC] Act (RA 11332) of 2019 ensures that all Filipinos have access to quality, cost‐effective, promotive, preventive, curative, rehabilitative, and palliative health services without causing a financial burden. Recognizing the provision of essential surgery, in the context of primary healthcare is important. It should be accessible, continuous, comprehensive, and coordinated at the time of need – parallel to the principle of primary health care. Driven by this concept and experiences, the authors conceptualized and presented the Philippine Rural Surgery model for future development and implementation. This is envisioned to provide essential surgery among local rural primary health care settings that is universal, accessible, cost‐effective and safe. As this is still new in the Philippines, we proposed tenets and recommendations based on WHO Health System Strengthening building blocks to guide stakeholders in creating formal plans towards institutionalization under the principles of UHC. Such access to surgical service in the context of a unique socio‐demography of the Philippines would be essential in attaining the parameters and provisions set by the UHC Act.
Magnetohydrodynamic chemically reactive viscoelastic fluid flow through an inclined porous layer
Authors: Das Utpal J. 
Published: November 2022

AbstractAnalysis of a time‐independent magnetohydrodynamic viscoelastic fluid flow in a deformable inclined porous layer with first‐order chemical reaction has been investigated. Walters' fluid model has been used to study viscoelastic fluid. The walls are suctioned/injected at a constant rate. The expression representing the solution for solid displacement, fluid velocity, temperature, and concentration distribution is obtained. The effect of applicable parameters on solid displacement, fluid velocity, temperature, and concentration are discussed graphically, while skin friction, heat transfer, and mass transfer are revealed in a tabular structure. It is noticed that solid displacement, fluid velocity, and temperature profiles decrease when the viscoelastic parameter increase. Solid displacement enhances and the velocity of the fluid reduces owing to the influence of increasing drag parameter, whereas the reverse effect is seen for the volume fraction parameter. Nusselt number at the walls shows the opposite behavior for the viscoelastic parameter and Eckert number. Sherwood number at the walls shows opposite behavior for Reynolds number, Schmidt number, and radiation parameter. Also, the entropy generation number rises as a result of the influence of viscoelasticity and Eckert number.
Bone marrow stromal cells are sensitive to discrete surface alterations in build and post‐build modifications of bioinspired Ti6Al4V 3D‐printed in vitro testing constructs
Authors: Berger Michael B. , Cohen D. Joshua , Snyder Kyle , Sions John , Boyan Barbara D. , Schwartz Zvi 
Published: November 2022

AbstractCurrent standards in bone‐facing implant fabrication by metal 3D (M3D) printing require post‐manufacturing modifications to create distinct surface properties and create implant microenvironments that promote osseointegration. However, the biological consequences of build parameters and surface modifications are not well understood. This study evaluated the relative contributions of build parameters and post‐manufacturing modification techniques to cell responses that impact osseointegration in vivo. Biomimetic testing constructs were created by using a M3D printer with standard titanium–aluminum–vanadium (Ti6Al4V) print parameters. These constructs were treated by either grit‐blasting and acid‐etching (GB + AE) or GB + AE followed by hot isostatic pressure (HIP) (GB + AE, HIP). Next, nine constructs were created by using a M3D printer with three build parameters: (1) standard, (2) increased hatch spacing, and (3) no infill, and additional contour trace. Each build type was further processed by either GB + AE, or HIP, or a combination of HIP treatment followed by GB + AE (GB + AE, HIP). Resulting constructs were assessed by SEM, micro‐CT, optical profilometry, XPS, and mechanical compression. Cellular response was determined by culturing human bone marrow stromal cells (MSCs) for 7 days. Surface topography differed depending on processing method; HIP created micro‐/nano‐ridge like structures and GB + AE created micro‐pits and nano‐scale texture. Micro‐CT showed decreases in closed pore number and closed porosity after HIP treatment in the third build parameter constructs. Compressive moduli were similar for all constructs. All constructs exhibited ability to differentiate MSCs into osteoblasts. MSCs responded best to micro−/nano‐structures created by final post‐processing by GB + AE, increasing OCN, OPG, VEGFA, latent TGFβ1, IL4, and IL10. Collectively these data demonstrate that M3D‐printed constructs can be readily manufactured with distinct architectures based on the print parameters and post‐build modifications. MSCs are sensitive to discrete surface topographical differences that may not show up in qualitative assessments of surface properties and respond by altering local factor production. These factors are vital for osseointegration after implant insertion, especially in patients with compromised bone qualities.
Allogeneic hematopoietic stem cell transplantation in non‐Hodgkin lymphoma in Switzerland, 30 years of experience: Sooner is better
Authors: Rebmann Ekaterina , Nabergoj Mitja , Grandjean Bastien , Stakia Paraskevi , Stern Alix , Medinger Michael , Masouridi‐Levrat Stavroula , Dantin Carole , Schanz Urs , Baldomero Helen , Passweg Jakob , Nair Gayathri , Rovo Alicia , Chalandon Yves 
Published: November 2022

AbstractDue to relatively high nonrelapse mortality (NRM), allogeneic hematopoietic stem cell transplantation (allo‐HSCT) in non‐Hodgkin's lymphoma (NHL) remains the ultimate line of treatment but the only curable approach in a setting of relapse/refractory disease. Here, we conducted a retrospective, multicenter, registry‐based analysis on patients who underwent allo‐HSCT for NHL in Switzerland, over 30‐year (1985–2020) period. The study included 301 allo‐HSCTs performed for NHL patients in three University Hospitals of Switzerland (Zurich, Basel and Geneva) 09/1985 to 05/2020. We assessed in univariate and multivariable analysis the impact on survivals (overall survival [OS], relapse free survival [RFS], relapse incidence [RI], and non‐treatment related mortality [NRM]). The maximum follow‐up was 25 years with median follow‐up for alive patients of 61 months. The median age at allo‐HSCT was 51 years. Three‐ and ‐year OS was ‐ 59.5% and 55.4%; 3‐ and 5‐year PFS was 50% and 44%; 3‐ and 5‐year NRM was 21.7% and 23.6%. RI at 3 and 5 years was 27.4% and 34.9%. In conclusion, our analysis of the entire Swiss experience of allo‐HSCT in patients with NHL shows promising 5‐ and possibly 10‐year OS and relatively acceptable NRM rates for such population, the majority being not in complete remission (CR) at the time of transplantation.
Diffusion‐Weighted Imaging of the Abdomen: Correction for Gradient Nonlinearity Bias in Apparent Diffusion Coefficient
Authors: Wang Jian , Ma Chao , Yang Panpan , Wang Zhen , Chen Yufei , Bian Yun , Shao Chengwei , Lu Jianping 
Published: November 2022

BackgroundGradient nonlinearity (GNL) introduces spatial nonuniformity bias in apparent diffusion coefficient (ADC) measurements, especially at large offsets from the magnet isocenter.PurposeTo investigate the effects of GNL in abdominal ADC measurements and to develop an ADC bias correction procedure.Study TypeRetrospective.Phantom/PopulationTwo homemade ultrapure water phantoms/25 patients with histologically confirmed pancreatic ductal adenocarcinoma (PDAC).Field Strength/SequenceA 3.0 T/diffusion‐weighted imaging (DWI) with single‐shot echo‐planar imaging sequence.AssessmentADC bias was computed in the three orthogonal directions at different offset locations. The spatial‐dependent correctors of ADC bias were generated from the ADCs of phantom 1. The ADCs were estimated before and after corrections for the phantom 1 with both the proposed approach and the theoretical GNL correction method. For the patients, ADCs were measured in abdominal tissues including left and right liver lobes, PDAC, spleen, bilateral kidneys, and bilateral paraspinal muscles.Statistical TestFriedman tests and Wilcoxon tests.ResultsThe ADC bias measured by phantom 1 was 9.7% and 12.6% higher in the right–left and anterior–posterior directions and 9.2% lower in the superior–inferior direction at the 150 mm offsets from the magnetic isocenter. The corrected vs. the uncorrected ADCs measurements (median: 2.20 × 10−3 mm2/sec for both the proposed method and the theoretical GNL method vs. 2.31 × 10−3 mm2/sec, respectively) and their relative ADC errors (0.014, 0.016, and 0.054, respectively) were lower in the phantom 1. The relative ADC errors substantially decreased after correction in the phantom 2 (median: 0.048 and −0.008, respectively). The ADCs of all the abdominal tissues were lower after correction except for the left liver lobes (P = 0.13).Data ConclusionGNL bias in abdominal ADC can be measured by a DWI phantom. The proposed correction procedure was successfully applied for the bias correction in abdominal ADC.Evidence Level3.Technical EfficacyStage 1.
Monkeypox outbreak 2022: What we know so far and its potential drug targets and management strategies
Authors: Rabaan Ali A. , Abas Abdul Hawil , Tallei Trina Ekawati , Al‐Zaher Mona A. , Al‐Sheef Noor M. , Fatimawali  , Al‐Nass Esraa Z. , Al‐Ebrahim Eba A. , Effendi Yunus , Idroes Rinaldi , Alhabib Mather F. , Al‐Fheid Hussain A. , Adam Ahmad Akroman , Bin Emran Talha 
Published: November 2022

AbstractMonkeypox is a rare zoonotic disease caused by infection with the monkeypox virus. The disease can result in flu‐like symptoms, fever, and a persistent rash. The disease is currently spreading throughout the world and prevention and treatment efforts are being intensified. Although there is no treatment that has been specifically approved for monkeypox virus infection, infected patients may benefit from using certain antiviral medications that are typically prescribed for the treatment of smallpox. The drugs are tecovirimat, brincidofovir, and cidofovir, all of which are currently in short supply due to the spread of the monkeypox virus. Resistance is also a concern, as widespread replication of the monkeypox virus can lead to mutations that produce monkeypox viruses that are resistant to the currently available treatments. This article discusses monkeypox disease, potential drug targets, and management strategies to overcome monkeypox disease. With the discovery of new drugs, it is hoped that the problem of insufficient drugs will be resolved, and it is not anticipated that drug resistance will become a major issue in the near future.
Approaching COVID‐19 with epidemiological genomic surveillance and the sustainability of biodiversity informatics in Africa
Authors: Aborode Abdullahi Tunde , Huang Helen , Wireko Andrew Awuah , Mehta Aashna , Kalmanovich Jacob , Abdul‐Rahman Toufik , Sikora Vladyslav , Awaji Aeshah A. 
Published: November 2022

AbstractCOVID‐19 is an acute respiratory illness caused by Severe Acute Respiratory Syndrome‐Coronavirus 2 (SARS‐CoV‐2). The first case was reported in Africa on February 14, 2020 and has surged to 11 million as of July 2022, with 43% and 30% of cases in Southern and Northern Africa. Current epidemiological data demonstrate heterogeneity in transmission and patient outcomes in Africa. However, the burden of infectious diseases such as malaria creates a significant burden on public health resources that are dedicated to COVID‐19 surveillance, testing, and vaccination access. Several control measures, such as the SHEF2 model, encompassed Africa's most effective preventive measure. With the help of international collaborations and partnerships, Africa's pandemic preparedness employs effective risk‐management strategies to monitor patients at home and build the financial capacity and human resources needed to combat COVID‐19 transmission. However, the lack of safe sanitation and inaccessible drinking water, coupled with the financial consequences of lockdowns, makes it challenging to prevent the transmission and contraction of COVID‐19. The overwhelming burden on contact tracers due to an already strained healthcare system will hurt epidemiological tracing and swift counter‐measures. With the rise in variants, African countries must adopt genomic surveillance and prioritize funding for biodiversity informatics.
Determination of skarn garnet compositions using Raman spectroscopy
Authors: Zhu Qiaoqiao , Cook Nigel J. , Xie Guiqing , Ciobanu Cristiana L. , Ji Yunhao 
Published: November 2022

AbstractGarnet is a key and defining mineral of skarns and associated metalliferous deposits. Variation in garnet composition, commonly expressed by the proportions of different end‐members, is widely used to determine the physical–chemical features of hydrothermal fluids. Skarn garnets from the Fujiashan W‐Cu‐Mo deposit, eastern China, were investigated by Raman spectroscopy and electron probe microanalysis to assess the quantitative correlation between Raman band positions and proportions of garnet end‐members. Compositions and Raman band positions of so‐called “grandite” garnet (Adr18–98Grs0–79), where Adr and Gr are the end‐members andradite and grossular, respectively, display a spatial zonation at Fujiashan that correlates with the distance from the contact between skarn and causative intrusion. Raman band positions determined in the ranges 234–246, 351–368, 369–375, 515–544, 814–826, and 873–882 cm−1 demonstrate moderate to very strong (R2 up to 0.99) linear correlations with mol% andradite and grossular components. This is attributed to homovalent substitution between Fe3+ and Al3+ in the octahedral site, which has an indirect effect on bond lengths and angles of Si‐O vibration, resulting in linear variation of Raman band positions. The band between 515 and 544 cm−1 is the most sensitive to compositional variation, and its position enables robust estimation of end‐member proportions within 10% of results calculated from electron probe microanalysis. This research highlights the potential of Raman spectroscopy as a rapid, powerful method to assess the composition of skarn garnet, enabling accelerated construction of spatial zonation models for skarns during skarn deposit exploration.