bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated to stigma in mental health workers of Castilla y Leon. The role of burnout and work motivation
Authors: Pelayo-Terán J.M. , Zapico-Merayo Y. , Garcia Llamas M.E. , Vega-García S. , López-Zapico C. , Villa-Carcedo M.R. , Álvaro-Prieto Á. 
Published: September 2022

IntroductionStigma is one of the most important barriers to help-seeking, treating maintenance and recovery for people suffering mental disorders. These attitudes, when present in mental health workers, may have a negative effect on the quality of health care.Objectivesto evaluate the levels of stigma in a representative sample of mental health workers and to explore potential modifiable factors associated to stigma attitudes.MethodsAn online survey was conducted on the mental health workers of Castilla y León (Spain, 2409164 habs) while projecting the 2022 Mental Health Humanization plan in order to asses educational skills, burnout (Maschlach MBI), Professional Quiality of life (CVP-35) and Stigma attitudes (Mental Illness: Cinician’s Attitudes Scales, MICA4) together with sociodemographic and work position variables.Results193 workers completed completed the survey. Stigma Attitude values of the sample were low (MICA4: 31.71; SD:7.3) and burnout were low or medium (medium Emotional Exhaustion: 19.22; SD8.89; low Depersonalization: 4.91; SD:3.61; Medium Personal Accomplishment: 34,17; 6.3). In the linear regression (R2=0.249; F:11,527; p<0,001), a lower Stigma was predicted by psychologist (Beta:0,207; p=0,003) or psychiatrist position (Beta:0,204; 0,005), Self-efficacy assessed by the item “I am qualified” in the CVP-35 (Beta:-10,144; p=0,023), and a higher stigma was predicted by nurse assistant position (Beta: -0.230; p=0.001), Depersonalization Burnout dimension (Beta:0,351; p<0,001) and years of service (Beta:0.148; p=0,023)ConclusionsSome groups of mental workers are more vulnerable to develop stigma attitudes. These, may be increased by fatigue and burnout. Future interventions should determine if reducing burnout and increasing capacitation may be effective in stigma eradicationDisclosureNo significant relationships.
Efficient self-regulation of human functional states as a predictor of work success under long-term innovation stress
Authors: Kuznetsova A. , Titova M. 
Published: September 2022

IntroductionResearch data indicate the necessity of efficient human functional states’ (HFS) self-regulations for successful work execution, and not only for those professionals, who work under extreme work conditions; efficient HFS self-regulation is discussed as one of the key professional competences in socionomic jobs as well (Friedman, 2003; Landy & Conte, 2021). Moreover, ability of efficient HFS self-regulation could be viewed as a differentiative competence for separation of professionals with normal and high work achievements (Spencer L. & Spencer S., 1993).ObjectivesThe empirical study was targeted to investigate HFS self-regulation efficiency as a predictor of work success under long-term innovation stress.MethodsThe longitudinal research was conducted in college teachers (n=50) during the period of organizational innovations. The empirical data were obtained by the diagnostic set of methods for self-assessment of attitudes towards innovations as a factor of long-term work strain, coping strategies and self-regulation means, chronic fatigue and burnout as the main consequences of long-term stress manifestations (Hobfoll, Dunahoo, Ben-Porath & Monnier, 1994; Leonova, 2012).ResultsThe significant diversity in the level of HFS self-regulation efficiency in teachers with different work success has been found (p<0,05). Teachers with the highest level of work results have a well-developed system of self-regulation means, which allows them to cope with innovation stress.ConclusionsThe empirical data revealed patterns of effective self-regulation means, which are adequate to situational requirement, professional norms and rules of organizational behavior. Obtained results formed the basis for the elaboration of training course for HFS self-regulation skills development.DisclosureNo significant relationships.
Incidence and predictive factors of non adherence to therapy in young adults attending a psycho social center in Milan: a retrospective observational “Real world” study
Authors: Vanzetto S. , Cirnigliaro G. , Piccoli E. , Dagoberti S. , Vismara M. , Benatti B. , Viganò C. , Dell’Osso B. 
Published: September 2022

IntroductionNon adherence to psychotropic drugs is associated with negative outcomes, including hospitalizations, aggressive behaviors, suicide attempts and increased premature mortality. It represents a psychiatric challenge, especially in young adults who show higher risk of non-adherence to treatmentObjectivesFirstly this study evaluates the incidence of non-adherence to therapy in 18-24 years patients from a Psycho-Social Center in Milan; and then to analyze the predictive factors of non-adherence.MethodsIn this retrospective “Real Life” observational study, 120 outpatients aged 18 to 24 years, from Psycho-social Center of L. Sacco University Hospital in Milan, were recruited in 2019. Non-adherence to treatment, according to the World Health Organization, was considered “a modality of assuming medications that does not correspond to healthcare professionals’ recommendations”. Statistical analysis were performed with chi-square, ANOVA and linear regression tests, setting significance to p<0.05.Results88 of 120 outpatients (73.3%) received an indication to psychopharmacological treatment. Of these, 23 (26.1%) did not show adherence to therapy. Results showed a positive association between non-adherence and increased hospitalizations (p <.01), oral antipsychotics (p<.05) and drop-out rates (p<.001). A significant correlation was also observed between non-adherence and Intellectual Disability (p<.05), Bipolar Disorder (p<.05), psychotic symptoms (p<.05), alterations in affectivity and mood (p<.005), alterations in sleep pattern (p<.05), school dropout (p<.05) and poor family support (p<.01).ConclusionsThis study confirms that non-adherence has a relevant incidence in young-adults psychiatric population, highlighting the importance of effective and structured assessment in clinical practice to identify predictive factors and risk profiles associated with this phenomenon.DisclosureNo significant relationships.
Multidisciplinary Approach in Diagnosing Patients with Mental Health and Intellectual Disability
Authors: Krysta K. 
Published: September 2022

It is possible to properly diagnose and treat a person with intellectual disability and mental health problems, but it requires a lot of work on the part of a doctor, nurse, professional medical care, proper rehabilitation and cooperation with a speech therapist, psychiatrist and many others. To improve the functional capacity of this person, it requires the help of a wide variety of professionals to meet their needs. One of the examples of interdisciplinary cooperation in this area is the “Circles of Support” program implemented by the Polish Association for People with Intellectual Disability in Poland. Support circles assume the creation of a group of supporters around a person with a disability, in accordance with their needs, combining formal (family doctor, psychiatrist, psychologist, personal assistant, social worker, therapist, lawyer) and informal support (family, friends, acquaintances, neighbors) , salesperson in your local store). The support is strictly focused on the needs of a person with a disability, and according to their individual preferences, it is fully inclusive. This goal can be achieved by preparing a person with a disability and the environment in a way that enables them to function safely in their local community based on the concept of supportive circles. The only way to build a system of care for of people with intellectual disabilities and their relatives is to rely on networks of connections - people and institutions, on their real commitment and on working out mechanisms supporting the empowerment of people with disabilities - in life, physical, financial matters.DisclosureNo significant relationships.
Explanations on school task procrastination reported by medical students: A qualitative study at a public university in South-eastern Brazil
Authors: Turato E. , Gonzalez L. 
Published: September 2022

IntroductionHow do medical students, who have self-criticism of being procrastinators of their study obligations, deal psychologically with daily tasks? The experience of procrastination by those who are considered high-performance students involves resources of mental health to cope with guilt, exhaustion, or even self-sabotage. According to MeSH used by PubMed, procrastination is ‘the deferment of actions or tasks to a later time, or to infinity’.ObjectivesTo explore the psychological meanings that medical students attribute to procrastination phenomena to better understand how they handle the usual curriculum overload.MethodsClinical-qualitative design. Sample of 13 participants closed by information saturation with 2nd, 3rd, 4th-year students. Semi-directed interviews with open-ended questions in-depth. Clinical-qualitative content analysis, free-floating readings with psychodynamic concepts. Results were validated by peers at the Laboratory of Clinical-Qualitative Research.ResultsEmergent categories: 1) between procrastination and despair: the process of stress in procrastination; 2) a proving mechanism: procrastination as an emotional defense; 3) a very delicate rumination: between procrastination and mere delay, an emotional dilemma; 4) this conflict is painful: the confrontation between the desire to comply with tasks with excellence and the enjoyment of life.ConclusionsProcrastination is reported by students as a source of great tension generated by opposing forces and desires, in which exhaustion is eventually reached. There are emotional contradictions related to guilt for leaving tasks to the last moment and the need to live other things besides doing academic tasks. Procrastination is a message-metaphor. It is important that institutions listen to students to understand what procrastination is saying about them.DisclosureNo significant relationships.
Utilitarian Concept of Mind and Mental Health
Authors: Jain S. , Thirunavukarasu M. 
Published: September 2022

IntroductionMany classification system and mental health act in many country attempted to define mental illness but mental health perse has not been defined.Some unaddressed question like ” what is diseased in mental illness, what do you treat or set right by treatment, how the psychiatrist say that a pateint is improved and describe or define mental health” are addressed.ObjectivesWorking concept for professionals of all allied clinical disciplines. Enable them to understand mental illness and mental health in a uniform and consistent way. Enable all MHP to speak the same language, without room for personal bias. Avoid misconceptions and reduce the stigma with mental illnessMethodsWe divided spectrum of mental health into Mentally Healthy, Not Healthy, Unhealthy and ill . Based on two dimension: 1. impact on self and 2. Impact on other. Awareness of ones own self, ability to relate well with other and ones own actions are useful to self as well as others are the three arms of mental health.ResultsA presentation was given to psychiatrist & allied sciences professional & members from judicairy, technolocrats, industrialist and educationist. Interaction was recorded and analysed, people even gave their responses comments and suggestions by mail and writing.ConclusionsMind is defined as a functional concept consists of Mood Thought and Intellect which is nicely amalgamated in a synchronised manner which always function in unison and the constituents cannot function in isolation. The three arms of the mental health are used to develop a tool to measure the same. All details will be discussed during the presentation.DisclosureNo significant relationships.
Hidden role of gut microbiome in mental health
Authors: Duarte A. , Simões I. , Cordeiro C. , Martins P. 
Published: September 2022

IntroductionThe recent literature indicates that the gut microbiota may affect brain functions through endocrine and metabolic pathways, antibody production and the enteric network while supporting its possible role in the onset and maintenance of several neuropsychiatric disorders, neurodevelopment and neurodegenerative disorders.ObjectivesThe aim of this work is to discuss the role of probiotics, prebiotics, or synbiotics as a potential treatment for symptoms of depression, anxiety, and stress.MethodsPub Med database was searched using following key words: “probiotics”, “prebiotics”, “mental disorders”, “psychological disorders”.ResultsAlthough the exact mechanism is unknown, there is a link between the gut and mood disorders. Psychosocial factors, such as quality of life or well-being, are greatly influenced by gut function and there is a strong correlation between psychosocial features and gastrointestinal disorders. Elevated stress, anxiety, and depression are linked to intestinal dysbiosis and mood disorders are disproportionately high in patients with functional gut disorders. So, psychobiotics may provide benefit when used in conjunction with current antidepressant medications. Probiotics may exert their therapeutic benefits by restoring microbial balance in the gut, and also by minimizing gastrointestinal complaints, allowing for the effects of antidepressant medication to not be reduced. Stress and immune responses were improved following psychobiotic intervention in stressed adults. Psychobiotics offer potential alternative treatment options in mood disorders and their accompanying symptoms.ConclusionsPro and prebiotics can improve mental health and psychological function and can be offered as new medicines for common mental disorders. However, more clinical studies are required to support the clinical use of probiotics.DisclosureNo significant relationships.
From Mild Encephalitis Hypothesis to Autoimmune Psychosis - and remaining challenges
Authors: Bechter K. 
Published: September 2022

IntroductionThe mild encephalitis (ME) hypothesis of severe mental disorders, ME to be caused by infections, autoimmunity , toxicity and trauma ( Bechter 2001, updated Bechter 2013), is now emergingly supported from neuroimaging and CSF and postmorten findings.ObjectivesReview about the present status of ME hypothesis and autoimmune psychosis and remainig challenges to assess and categorize mild neuroinflammation.Methodsexpert reviewResultsAutoimmune Encephalitis presenting with exclusive psychiatric symptoms and all cases of Autoimmune Psychosis (international consensus criteria in Pollak et al, Lancet Psychiatry, 2020) match the proposed ME criteria ( Bechter 2001 & 2013). Majority of these cases of an autoimmune type of ME are well treatable with immune modulatory treatments. It remained unclear, whether CNS antibodies are causal or contributive by shaping the observed clinical syndrome. The increasing evidence of mild neuroinflammation present in considerable subgroup of schizophrenia or psychosis spectrum cases from ongoing clinical studies, including CSF ( Bechter et al 2010, Endres et al 2018, 2020, aso.) and neuroimaging plus the observed clinical improvement with immune modulytory therapies, strongly support ME hypothesis, potentialy even in considerably larger subgroup of SMDs,supported by brain biopsy (Najjar et al ,several papers) and post mortem studies (Bogerts et al group ,Weickert et al group, several papers).ConclusionsBeyond ME even more refined categories of mild neuroinflammation, including parainflammation ( proposed by Medzhitov 2008) and neuroprogression ( proposed by Berk et al 2010/11) need to be considered in further research on the possible role of mild neuroinflammation in SMDs (Bechter 2020, Frontiers Psychiatry).DisclosureNo significant relationships.
“I want to kill my mother”
Authors: Tan H.T. 
Published: September 2022

IntroductionThe incidence of Anti-NMDA receptor encephalitis is 1.5 per million population per year but it has only been described sporadically in the paediatric population. The median age of onset is 21 years old. In children, seizures, abnormal movements, insomnia, and irritability are more frequently identified than psychosis or abnormal behavior. Early detection and treatment can improve treatment outcomes.ObjectivesPresentation of a case of a paediatric patient with Anti-NMDA receptor encephalitis displaying homicidal behavior towards her family membersMethodsCase reportResultsA 12 year old with no significant past psychiatric and medical history, was brought in by police to the hospital after she attempted to stab her mother with a knife. She had low grade fever, headaches and lethargy prior to presentation. Organic workup revealed serum and CSF anti-nmda receptor to be positive. She received early treatment with steroids and intravenous immunoglobulins and no longer harboured further homicidal ideations.ConclusionsInitial suspicion of anti-NDMA receptor encephalitis should be raised and early auto-immune workup performed in paediatric patients presenting with acute change in behavior especially in young females with no past medical or psychiatric historyDisclosureNo significant relationships.
Association between markers of inflammation and indicators of systemic endotoxemia in endogenous psychosis
Authors: Zozulya S. , Oleichik I. , Otman I. , Yakovlev M. , Klyushnik T. 
Published: September 2022

IntroductionThe clinical and biological studies indicate the involvement of inflammation in the pathogenesis of endogenous mental disorders. The inflammation markers leukocyte elastase, α1-proteinase inhibitor, and autoantibodies to neuroantigens reflect the severity of the pathological process in the brain. Systemic endotoxemia is a pathological process caused by an excess of endotoxins in the systemic circulation, can be considered as one of the components of the inflammatory process in endogenous psychosis.ObjectivesTo evaluate the association between systemic inflammation markers and indicators of systemic endotoxemia in patients with endogenous psychosis.MethodsThe study included 25 patients aged 23-49 with endogenous psychoses (F20, F25) and 25 healthy people. The severity of symptoms was assessed using PANSS. We detected the activity of leukocyte elastase and a1-proteinase inhibitor, antibodies to neuroantigens, endotoxin (ET) concentration, and antibodies to endotoxin (aEТ) in serum.ResultsIn 24% of cases, an increase of inflammation markers activity, ET concentration, and aET deficiency were observed (p<0.05), which is an unfavorable factor that aggravates the clinical course of the disease. In 76% of cases, ET concentration remained within control values (p>0.05) but associated with different levels of aET, which is likely to be a consequence of previous endotoxin aggression. There were correlations between ET concentration and antibodies to neuroantigens S-100B and MBP. We also revealed the association between the activity of the inflammatory marker with the severity of clinical symptoms in patients.ConclusionsResults suggest the relationship between systemic inflammation markers and indicators of systemic endotoxemia and their involvement in the pathogenesis of endogenous psychosis.DisclosureNo significant relationships.
Immunoregulatory and neuroprotective activity of ovocystatin
Authors: Stańczykiewicz B. , Gburek J. , Gołąb K. , Konopska B. , Zabłocka A. 
Published: September 2022

IntroductionOvocystatin has beneficial properties for cognitive function in young rats and might prevents aging-related cognitive impairment in older animals, as well as reduces memory decline in APP/PS1 mice model.ObjectivesOur study aimed at assessing the impact of ovocystatin on microglia activation and neurogenesis.MethodsImmunoactivation: Mouse wild type microglia were stimulated with ovocystatin at dose of 100 micrograms/ml. The effect of ovocystatin on nitric oxide production and interleukin 1 beta secretion were determined. Neurogenesis: Primary rat hippocampal neurons of H19-7 cell line was used. The impact of ovocystatin on proliferation, nitric oxide production, and expression of markers of neurogenesis: microtubule-associated protein 2 (MAP2, isoforms A/B and C/D) and Synapsin 1, were determined.ResultsIt was shown that ovocystatin does not stimulate microglial cells to produce inflammatory mediators. Whereas, no toxic effect of ovocystatin (1-100 ug/ml) on H19-7 cells viability, and dose-dependent down-regulation of proliferation were demonstrated. It was also shown that in primary hippocampal neurons of H19-7 cells incubated with ovocystatin (100 micrograms/ml), the expression level of MAP2 C/D (75kDa) - characteristic form of immature neurons is unchanged. However, the increased expression of MAP2 A/B protein (280 kDa) – characteristic for mature neurons was observed after 6 and 24h incubation with ovocystatin. Relatively to MAP2 A/B, increased expression of synapsin 1 was observed.ConclusionsThe ovocystatin might be a potential activator of molecular mechanisms in primary hippocampal neurons, participating in regulation of neurogenesis. Nevertheless, further studies are needed.DisclosureNo significant relationships.
Immunology and psychosis: 22q11.2 syndrome as a model of study
Authors: Garcia-Bernal C. , El-Idrissi Benhnia M.R. 
Published: September 2022

IntroductionThe 22q11.2 deletion syndrome (22q11DS) defines a set of developmental abnormalities due to a loss of genetic material. Phenotypic expression is highly varied. The immunological alterations that present as a severe combined immunodeficiency and the neurodevelopmental alterations stand out, especially the psychotic symptoms. It is the best described genetic alteration for the development of psychosis, presenting up to 30% of patients with compatible symptoms, with various hypotheses that justify it.ObjectivesGeneral objective:1. Justify that SD2q11 can be used as a model for human research on the origin of psychosis.Specific objectives1. Describe the pro-inflammatory state present in SD2q11.2. Describe differences at the immunological level in SD2q11 among those patients with presence of psychotic symptoms of those who do not present them.3. Describe possible biomarkers.MethodsA systematic review of the literature in the last 5 years using electronic resources (PubMed and WOS) until June 2021 following the PRISMA recommendations.ResultsThree original articles were reviewed. There is a very marked pro-inflammatory state in 22q11DS patients with psychotic symptoms. They present an increase in subpopulations of CD4. The IL-17 is important in the formation in primitive stages of the hippocampus, its ease of breaking the blood-brain barrier (BBB). The neutrophil / lymphocyte ratio is presented as a possible biomarker to predict patients at high risk of developing psychosis.ConclusionsThere is sufficient evidence that patients with 22q11DS can be used as a research model regarding possible hypotheses about the genesis of psychosis.DisclosureNo significant relationships.