bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between PEEP levels, central venous pressure, systemic inflammation and AKI in critically ill ventilated COVID-19 patients. A monocenter retrospective study
Authors: Basse Pierre , Morisson Louis , Barthélémy Romain , Julian Nathan , Kindermans Manuel , Collet Magalie , Huot Benjamin , Gayat Etienne , Mebazaa Alexandre , Chousterman Benjamin G. 
Published: August 2022

Abstract
Introduction:
The role of positive pressure ventilation, central venous pressure (CVP) and inflammation on the occurrence of acute renal failure (AKI) have been poorly described in mechanically ventilated patient secondary to Sars-Cov-2 infection (Covid-19).
Methods
This was a monocenter retrospective cohort study of consecutive ventilated COVID-19 patients admitted in a French surgical ICU between Mars 2020 et July 2020. Worsening renal function (WRF) was defined as development of a new AKI or a persistent AKI during the five days after mechanical ventilation initiation. We studied the association between WRF and ventilatory parameters including positive end pressure (PEEP), CVP, and leukocytes count.
Results
57 patients were included, 12 (21%) presented WRF. Daily PEEP, 5 days mean PEEP and daily CVP values were not associated with occurrence of WRF. 5 days mean CVP was higher in the WRF group compared to patients without WRF (median 12 [IQR, 11–13] mmHg vs 10 [9–12] mmHg, p = 0.03). Multivariate models with adjustment on leukocytes and SAPS II confirmed the association between CVP value and risk of WRF, odd ratio: 1.97 (IC95: 1.12–4.33). Leukocytes count was also associated with occurrence of WRF (14.3 [11.3–17.5]) G/L in the WRF group vs 9.2 [8.1–11.1] G/L in the no-WRF group) (p = 0,002).
Conclusion
In Mechanically ventilated COVID-19 patients, PEEP levels did not appear to influence occurrence of WRF. High CVP levels and leukocytes count are associated with risk of WRF.
On the non-linearity of radon-induced lung cancer
Authors: Rosenberger Albert , Bickeböller Heike , Christiani David C , Liu Geoffrey , Schabath Matthew B , Duarte Luisa F. , Marchand Loic Le , Haiman Christopher , Landi Teresa , Consonni Dario , Field John K , Davies Michael P.A. , Albanes Demetrios , Tardon Adonina , Fernández-Tardón Guillermo , Rennert Gad , Rennert Hedy , Amos Christopher I , Hung Rayjean J 
Published: August 2022

Abstract
Background: Exposure to low doses of the radioactive gas radon, as found indoors in dwellings, has been consistently shown to be a risk factor for lung cancer (LC). The linear-no-threshold hypothesis (LNT) is often applied to estimate excess odds ratios or population attributable risks, albeit this LNT assumption remains debated. Aim/Method: We investigate the profile of radon-induced LC-risk in a sample of 8,927 cases and 5,562 controls of the International Lung Cancer Consortium (ILCCO), contributed by studies with sufficient exposure heterogeneity. Spatial indoor-radon exposure in the residential area (sIR) obtained from the national surveys were linked to the participants’ residential geo-location. Parametric linear- and spline-functions were fitted within framework of logistic regression. Results: We observed a U-shaped dose-risk relation, with the lowest risk exposure level (LRE) being 57.6 Bq/m³ (95%.CI: 56.1-59.2 Bq/m³). The risk of overall-LC at 25 Bq/m³ (OR=1.31, 95%-CI: 1.01-1.59) was comparable to that at 100 Bq/m³ (OR=1.34, 95%-CI: 1.20-1.45). Regarding histological subtypes, we observed the strongest risk for small-cell LC, and weak association for squamous-cell LC with no association below 58 Bq/m³. Conclusion: Our results showed a U-shaped risk-profile for radon-induced LC risk at very low exposure levels (sIR<200 Bq/m³), lowest in areas of mean indoor radon levels of about 58 Bq/m³. Risk profiles differ between histological subtypes, and sex, age and smoking behaviour modify the lowest risk thresholds. sIR is a useful proxy for radon exposure, and the linearity-no-threshold assumption in this data seems not optimal for the dose-response relation of sIR less than 200 Bq/m³.
Microbiome Mediates Development of PTSD and Resilience
Authors: Feldman Ruth , Yirmiya Karen , Turjeman Sondra , Shtossel Oshrit , Zagoory-Sharon Orna , Moadi Lelyan , Louzoun Yoram , Koren Omry 
Published: August 2022

Abstract
Identification of youth at risk for post-traumatic pathology is critical for public health, medicine, and social policy but research has not yet succeeded in pinpointing biomarkers that can distinguish the post-traumatic from the resilient profile in contexts of trauma. As trauma alters the microbiome with lasting effects on the host, the current longitudinal, multi-measure, cross-species study sought to outline the microbial signature of post-traumatic stress disorder (PTSD). We followed a unique trauma-exposed cohort for 15 years, from early childhood to adolescence, repeatedly assessing post-traumatic symptomatology. Gut microbiome composition and diversity characterized post-traumatic pathology, distinguished youth with PTSD from resilient individuals, and mediated the continuity of post-traumatic disorder. Mother-child microbial synchrony was reduced in cases of PTSD, suggesting that diminished microbial concordance among family members may index susceptibility to post-traumatic illness. Germ-free mice transplanted with PTSD microbiomes compared with those receiving resilient microbiomes exhibited anxious behavior. Our findings provide causative evidence that the microbial trauma profile is at least partially responsible for the trauma-related phenotype and highlight microbial underpinnings of resilience. Our results suggest that the microbial ecology may serve as additional biological memory of early life stress and underscore the potential for microbiome-related diagnosis and treatment following trauma exposure.
Therapeutic capability of selected medicinal plants' bioactive constituents against the mutant ovarian TP53 gene; A computational approach.
Authors: Raheem Kayode Yomi , Ibukunoluwa Fawehinmi Praise , Olorundare Solomon Ayodele , Abayomi Modinat Aina , Uchechukwu Egbe Justine , Adewunmi Mary , Kuyet Zichat blessing , Anthony Modupe Mercy , Gbadebo Mary Ikeoluwa 
Published: August 2022

Abstract

Background
The pivotal role of mutant P53 protein in Ovarian cancer and the efficacy of natural compounds in cancer treatment necessitated the current study to identify novel mutant P53 modulators from medicinal plants. Homology modelling was deployed to assemble the 3-D structure of the mutant P53 protein from its amino acid sequences, while Findsitecom2.0 was used to predict the active binding site of the mutant P53 protein model. The bioactive constituents obtained from seven plants were used as ligands and docked against the binding pocket of mutant P53 protein. Autodock tools, PyRx and Discovery Studio, were used to prepare the protein, dock the ligands and visualize the complexes, respectively. Thiotepa and Germcitabine were used as reference drugs. The hit compounds were selected based on their highest binding affinity and further analyzed to identify their pharmacokinetic properties and acute Rat Toxicity using SWISSADME and Gusar, with their electronic properties calculated using the density functional theory(DFT) method.
Results
Screening results of 50 bioactive phytochemicals confirmed that 15 leads showed superior binding energies to mutant P53 as compared to the standard FDA-approved drugs (Thiotepa and Germcitabine with binding scores of -3.5 and − 5.4, respectively). After considering their drug-like, pharmacokinetic properties and acute toxicity prediction, four major hits (Morusin, Irinotecan, Rubitecan, and 10-hydroxycamptothecin) were identified to have minimal toxicities and are safe to be used. The DFT calculations showed regions of the molecules prone to electrophilic and nucleophilic attacks.
Conclusions
The current study revealed drug-like compounds that can serve as potential modulators of mutant P53 in Ovarian cancer treatment.
Effect of short-term use of FFP2 mask on salivary metabolome of young healthy volunteers: A pilot study.
Authors: Islam Sk Ramiz , Prusty Debasish , Dutta Raju , Maiti Subhadip , Chattopadhyay Partha , Manna Soumen Kanti 
Published: August 2022

Abstract
Use of face mask has become an integral part of public life in the post-pandemic era. However, the understanding of the effect of wearing mask on physiology remains incomplete and is required for informing public health policies. Earlier studies indicated changes in breath and blood gas composition upon wearing FFP2 mask. For the first time, we report analysis of the effect of wearing FFP2 mask on metabolic composition of saliva, a proximal matrix to breath. Un-induced saliva was collected from healthy volunteers (n =10) before and after wearing FFP2 mask for 30 minutes and analyzed. Results showed that such short-term mask use did not cause any significant change in heart rate, pulse rate and SpO2. The individuality of overall salivary metabotype was found to be robust and unaffected by mask use. There were marginal increases in relative abundances of L-fucose, 5-aminovaleric acid, putrescine, phloretic acid and benzenepropionic acid. Results indicated that while there were no adverse changes in physiological parameters and salivary metabotype, mask use was associated with changes in microbial metabolic activity. Consequences of such changes remain to be examined. However, these might explain change in odour perception that was reported to be associated with mask use.
Extraction and Discussion of Influencing Factors in Self-driving Ethical Decision
Authors: Liu Guoman , Luo Yufeng , Sheng Jing 
Published: August 2022

Abstract
At present, many scholars found many influencing factors in self-driving ethical decision by the way of questionnaire and theoretical researches. However, the important influencing factors can’t still be extracted and determined in self-driving ethical decision, which is not conducive to construct decision model and framework in moral dilemmas and causes information overlap and interference by multi-variable and multi-collinearity. Therefore, it is necessary to extract a few important factors from these influencing factors in self-driving ethical decision. 116 normal dilemmas and 10 comparative dilemmas, in which there are only two influencing factors to be compared, are designed to be surveyed in this paper. According to the probability of the straight choosing as protector, the comparative result and location in decision tree model, the importance is determined in self-driving ethical decision, then a few important influencing factors are extracted and determined in self-driving ethical decision. Eventually, these factors of species, harm, traffic laws, number, age and self-interests are regard as the important influencing factors in self-driving ethical decision, which provide a few theoretical guidance to construct and design model and framework in self-driving ethical decision for car manufactures. Furthermore, they provide a few references to formulate traffic laws and regulations related to self-driving technology for traffic management authentication.
Diagnosis and management of a patient with 5 FU-induced ST elevation and nonsustained VT as a late presentation of cardiotoxicity and successful rechallenge of 5-FU
Authors: Medepalli Lalitha C , S.Mahmood Tariq , Liberman Henry , Medepalli Anita M. , Bagwell Thomas W. 
Published: August 2022

Abstract
5-FU is an antimetabolite drug that is used to treat cancer. It is usually administered to decelerate and prohibit cancer cell proliferation. It acts by inhibiting the enzyme thymidylate synthase by blocking the thymidine formation required for DNA synthesis [1]. The most common clinical manifestation of 5-FU cardiotoxicity is chest pain related to coronary vasospasm [2]. An increase in endothelin-1, a vasoconstrictor, and a decrease in prostacyclin, a vasodilator, is thought to be the cause of endothelial dysfunction, which typically results in coronary vasospasm [3]. Cardiotoxicity induced by 5-FU carries a high risk of morbidity and mortality if it is left untreated [3]. Patients experiencing cardiotoxicity induced by 5-FU present with signs and symptoms of acute coronary syndromes with elevated cardiac biomarkers (troponin), and their ECGs often reveal ST segment differences. There can be two distinct clinical presentations, early or late presentation of cardiotoxicity. Usually, with early toxicity, troponin elevation may be evident. However, in late presentation of cardiotoxicity symptoms, troponin elevation and/or ECG changes may be undetectable. Our case has a unique presentation of 5-FU toxicity in a patient developing ST elevation and nonsustained ventricular tachycardia as a late presentation of cardiotoxicity. Despite the malignant presentation of this vasospasm with continuous infusion 5-FU administration (modified FOLFOX6), our patient was successfully treated and rechallenged with complete bolus 5-FU (FLOX) neoadjuvant chemotherapy. Chakrabarti, S. et al performed a retrospective review of approximately ten patients to explore the safety of substituting FLOX (bolus 5-FU, oxaliplatin, leucovorin) for FOLFOX (infusional 5-FU, oxaliplatin, leucovorin) and CAPOX (capecitabine, oxaliplatin) in patients who had 5-FU-induced coronary vasospasm. Out of the 10 patients, 8 patients had chest pain as the presenting complaint within 48 hours after beginning the 5-FU infusion. In 9 out of the 10 patients, coronary vasospasm occurred during the first cycle of therapy. All of the patients made a full recovery after the discontinuation of infusion of 5-FU or capecitabine. Subsequently, all patients received FLOX from 7 days to 18 months after the event, with 7 patients treated within 4 weeks of the event. FLOX did not cause any cardiovascular adverse events in any of the 10 patients [4]. Because our patient manifested malignant ST elevation and ventricular tachycardia during the late presentation coronary spasm with 5-FU, the cardio-oncology multidisciplinary team administered a vasodilator pre- and posttreatment regimen. This regimen was described previously in the literature for late presentation of 5-FU cardiotoxicity [5].
Web-Based Perspectives of Deemed Consent Organ Donation Legislation in Nova Scotia: Thematic Analysis of Commentary in Facebook Groups
Authors: Marcon Alessandro R , Wagner Darren N , Giles Carly , Isenor Cynthia 
Published: August 2022

BackgroundThe Canadian province of Nova Scotia recently became the first jurisdiction in North America to implement deemed consent organ donation legislation. Changing the consent models constituted one aspect of a larger provincial program to increase organ and tissue donation and transplantation rates. Deemed consent legislation can be controversial among the public, and public participation is integral to the successful implementation of the program.ObjectiveSocial media constitutes key spaces where people express opinions and discuss topics, and social media discourse can influence public perceptions. This project aimed to examine how the public in Nova Scotia responded to legislative changes in Facebook groups.MethodsUsing Facebook’s search engine, we searched for posts in public Facebook groups using the terms “deemed consent,” “presumed consent,” “opt out,” or “organ donation” and “Nova Scotia,” appearing from January 1, 2020, to May 1, 2021. The finalized data set included 2337 comments on 26 relevant posts in 12 different public Nova Scotia–based Facebook groups. We conducted thematic and content analyses of the comments to determine how the public responded to the legislative changes and how the participants interacted with one another in the discussions.ResultsOur thematic analysis revealed principal themes that supported and critiqued the legislation, raised specific issues, and reflected on the topic from a neutral perspective. Subthemes showed individuals presenting perspectives through a variety of themes, including compassion, anger, frustration, mistrust, and a range of argumentative tactics. The comments included personal narratives, beliefs about the government, altruism, autonomy, misinformation, and reflections on religion and death. Content analysis revealed that Facebook users reacted to popular comments with “likes” more than other reactions. Comments with the most reactions included both negative and positive perspectives about the legislation. Personal donation and transplantation success stories, as well as attempts to correct misinformation, were some of the most “liked” positive comments.ConclusionsThe findings provide key insights into perspectives of individuals from Nova Scotia on deemed consent legislation, as well as organ donation and transplantation broadly. The insights derived from this analysis can contribute to public understanding, policy creation, and public outreach efforts that might occur in other jurisdictions considering the enactment of similar legislation.
Pengembangan Lembar Kerja Mahasiswa Berbasis KKNI Pada Mata Kuliah Pertumbuhan, Perkembangan Gerak
Authors: Supriadi Amir , Dewi Rahma , Hardinoto Nono , Mahmudin Mahmudin 
Published: August 2022

Penelitian ini bertujuan untuk menghasilkan produk lembar kerja berbasis KKNI mata kuliah pertumbuhan dan perkembangan belajar gerak berupa print-outt lembar kerja. Dengan produk ini diharapkan dapat memecahkan masalah pada mahasiswa yang kesulitan dalam menyelesaikan enam tugaas, yaitu tugas rutin, tugas projek, tugas mini research, tugas critical jurnal, tugas book report, dan tugas rekaya ide pada mata kuliah pertumbuhan dan perkembangan belajar gerak sebagai dasar peningkatan kompetensi mahasiswa Fakultas Ilmu keolahragaan khususnya jurusan Pendidikan KepelatihaN Olahraga yang berkompetensi dalam bidang kepelatihan dan pendidikan jasmani. Implikasi dari produk lembar kerja tersebut akan mempermudah mahasiswa dalam menjalankan proses belajar mata kuliah pertumbuhan dan perkembangan belajar gerak.Penelitian ini menggunakan pendekatan research and development dengan mengembangkan lembar kerja yang didasarkan pada standar kompetensi melalui analisis kebutuhan dari mahasiswa.
Evaluasi Program Manajemen Pembinaan Cabang Olahraga Unggulan Provinsi Jambi Tahun 2018
Authors: Indrayana Boy , Setiawan Iwan Budi 
Published: August 2022

Penelitian ini secara umum bertujuan untuk mendapatkan informasi tentang penyelenggaraan manajemen pembinaan Cabang Olahraga Unggulan Provinsi Jambi. Secara khusus, penelitian ini bertujuan untuk: Mengetahui perencanaan manajemen pembinaan Cabang Olahraga Unggulan Provinsi Jambi, Mengetahui sistem pengorganisasian manajemen pembinaan Cabang Olahraga Unggulan Provinsi Jambi, Mengetahui pelaksanaan pembinaan Cabang Olahraga Unggulan Provinsi Jambi, Mengetahui hasil program pembinaan Cabang Olahraga Unggulan Provinsi Jambi. Penelitian ini bertempat di KONI Provinsi Jambi. Waktu yang digunakan selama penelitian mulai dari rencana penelitian (proposal) hingga penyusunan dilakukan bulan Febuari 2018 sampai dengan bulan Agustus 2018. Hasil dari penelitian ini adalah: (1) Kategori untuk aspek konteks pada Evaluasi program pembinaan cabang olahraga unggulan Provinsi Jambi tahun 2018 berada pada nilai sebesar 92.44 % pada kategori baik sekali, (2) Kategori untuk aspek input pada Evaluasi program pembinaan cabang olahraga unggulan Provinsi Jambi tahun 2018 berada pada nilai sebesar 79.24 pada kategori baik, (3) Kategori untuk aspek proses pada Evaluasi program pembinaan cabang olahraga unggulan Provinsi Jambi tahun 2018 berada pada nilai sebesar 91.39 % pada kategori baik sekali, (4) Kategori untuk aspek proses pada Evaluasi program pembinaan cabang olahraga unggulan Provinsi Jambi tahun 2018 berada pada nilai sebesar 79.35 % pada kategori baik.
Penggunaan Aplikasi Android Smart Parenting untuk Meningkatkan Pengetahuan Orang Tua tentang Bullying
Authors: Novianti Ria , Maria Ilga , Hukmi Hukmi 
Published: August 2022

Saat ini orang tua membutuhkan platform baru yang dapat diakses di mana saja dan kapan saja untuk mendapatkan informasi tentang bullying. Tujuan penelitian ini untuk meningkatkan pengetahuan orang tua tentang bullying menggunakan aplikasi smart parenting melalui penelitian eksperimen semu (quasy exsperiment) dengan desain the posttest-only control-group desain. Populasi dalam penelitian adalah orang tua anak usia dini yang berjumlah 30 orang di Kota Pekanbaru. Teknik yang digunakan dalam pengambilan sampel ini adalah teknik random sampling. Menggunakan dua kelas yakni kelas eksperimen untuk diberikan perlakuan dan kelas kontrol. Alat pengumpulan data berupa angket. Teknik analisis data menggunakan uji normalitas dan uji hipotesis. Hasil perhitungan menunjukkan penggunan aplikasi smart parenting dapat meningkatkan pengetahuan orang tua tentang bullying dengan hasil rata-rata eksperimen 77,77 dan kontrol 70,83. Dengan demikian, aplikasi smart parenting dapat membantu orang tua memahami definisi bullying, bentuk-bentuk perilaku bullying, hingga pencegahan dan solusi menghadapi permasalahan bullying
Teknik STAR dalam Self and Peer Assessment pada Pelaksanaan Model Pembelajaran ABCD5E di TK
Authors: Handayani Sri Wiji , Latiana Lita , Pranoto Yuli Kurniawati Sugiyo 
Published: August 2022

Asesmen merupakan bagian penting dalam pembelajaran khususnya dalam pelaksanaan model pembelajaran ABCD5E. Berdasarkan diskusi di lapangan bahwa para implementator model pembelajaran ABCD5E membutuhkan bagaimana cara melakukan asesmen pada pelaksanaan pembelajaran ABCD5E. Tujuan dari penelitian ini adalah untuk mendeskripsikan bagaimana self/peer assessment pada model pembelajaran ABCD5E dengan menggunakan teknik STAR. Metode penelitian yang digunakan adalah Studi Literature Review. Langkah dalam metode ini adalah dengan mencari referensi penelitian sebelumnya baik jurnal nasional maupun inernational. Pencarian dengan Riset Question PICOC Populasi (Population), Intervensi (Intervention), Perbandingan (Comparison), Hasil (Outcomes), dan Konteks (Context). Hasil dari penelitian ini adalah sebuah Teknik STAR dalam self/peer Assessment yang dapat digunakan pada pelaksanaan model pembelajaran ABCD5E di Taman Kanak-kanak.
Psychological effect of Online Learning- A study of college students
Authors: Nair Rejani 
Published: August 2022

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<p><em>The predictability of a student’s academic routine was affected badly due to the outbreak of covid-19. The prime time of their life which had been full of energy was now under lock, inside the four walls of their home. Confining them naturally had its own consequences and serious implications in their psychological wellbeing and on their overall health conditions.</em> <em>Many of them faced psychological problems like frustration, stress and depression. In order to study the psychological wellbeing of students in this period and to know about their mental, physical, social and emotional problems that they faced, a survey was conducted in Trivandrum district of Kerala State. A questionnaire comprising of five point Likert scale was used to collect the opinion of the students regarding the psychological wellbeing, general and academic stress level of students along with the problems and effect of online learning on their emotional, social, physical and mental health.</em> <em>Students t-test, Independent t- test, ANOVA, correlation etc. were the tests used in the study to analyze the data.</em></p>