bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Well, what do You Want to do?’ A Case Study of Community Palliative Care Programme: ‘Heidi’s Have a Go’
Authors: Stanley Moira A. , Daddow Angela A. 
Published: January 2022

The demand for palliative care has increased in high income countries as mortality in older adults has decreased and life expectancy increased. In this context, the priorities of palliative and end of life care (EoLC) have shifted in Australia, reflected in policy frameworks, national guidelines, service systems and funding models. However, aligning service systems and practice realities with these policy aspirations has been problematic in Australia and elsewhere. The current study investigates the recent implementation of a unique, community palliative care (CPC) programme called Heidi’s Have a Go (HHaG) in regional Australia, which seemed to bridge the problematic divide between policy aspirations and practice implementation. Qualitative research was undertaken to examine the programme design and influence from the perspective of programme staff and volunteers. The data generated compelling stories on staff and patient experiences in its first 2 years, achieving service outcomes aligned with current policy and national frameworks and privileging patient voices.
With Medicine in Mind? Exploring the Relevance of Having Recreational Experience When Becoming a Medicinal Cannabis User
Authors: Kvamme Sinikka L. 
Published: January 2022

Background: Beyond the legal use of medical cannabis in Denmark for selected patient groups, a large unregulated use of medicinal (non-prescribed) cannabis occurs. However, little is known about the paths to becoming a medicinal cannabis user and the role that previous recreational experience plays in this process. Aim: Inspired by Becker’s social learning approach to becoming a cannabis user, this study explores sources of inspiration for medicinal cannabis use, the social control factors related to use, and the relevance of recreational experience (RE) with cannabis. Methods: An anonymous survey was made available online to a convenience sample of 2,281 adults (≥18 years) who self-medicate with non-prescribed cannabis. Logistic regression analysis compared users with no RE (46.1%) to users with occasional RE (27.4%) and regular RE (26.5%) in terms of user characteristics, initiation of medicinal use, and experiences with social control factors. Results: Compared to users with RE, users with no RE were significantly more likely to be women, older, more frequent users, and to treat somatic conditions and use low potency CBD-oil. Users with no RE were more likely to rely on social networks for information on medicinal cannabis, use online sources for supply, and find supply stable. Moreover, users with no RE were less likely to keep use secret and find use problematic. Also, when medicinal use develops on a gradual transition from recreational use it is associated with increased odds of treating mental health conditions and with use of smoking as form of intake. Conclusion: The heterogeneity among medicinal cannabis users in Denmark, in terms of demographics, motives for use, and patterns of use, is related to the level of previous recreational experience and to whether medicinal use developed on a gradual transition from recreational use.
The Use of Concrete Examples Enhances the Learning of Abstract Concepts: A Replication Study
Authors: Micallef Alexia , Newton Philip M. 
Published: January 2022

Background Prior research suggests that the teaching of abstract concepts can be enhanced by the use of concrete examples, but there are few controlled studies. Objective To replicate key findings from experiment one from Rawson et al. (2015). Method Experiment participants studied definitions of abstract concepts from psychology, either with or without concrete examples. The replication differed from Rawson et al. by using a paid online participant pool, of non-psychology students, and a trimmed methodology focused on the key outcome. Results Concrete examples enhanced learning of abstract concepts. The critical finding was enhanced recognition of previously unseen examples matched to learned definitions, thus replicating the results of Rawson et al., with an effect size d = 0.30. Conclusion The use of concrete examples was found to enhance learning of abstract concepts when teaching concepts from psychology to non-psychology students using an online paid participant pool. Teaching Implications The teaching of abstract concepts in psychology could be helped by frequent use of concrete, real-world examples.
Spatiotemporal and Ground-Reaction Force Characteristics as Risk Factors for Running-Related Injury: A Secondary Analysis of a Randomized Trial Including 800+ Recreational Runners
Authors: Malisoux Laurent , Gette Paul , Delattre Nicolas , Urhausen Axel , Theisen Daniel 
Published: January 2022

Background: Running biomechanics may play a role in running-related injury development, but to date, only a few modifiable factors have been prospectively associated with injury risk. Purpose: To identify risk factors among spatiotemporal and ground-reaction force characteristics in recreational runners and to investigate whether shoe cushioning modifies the association between running biomechanics and injury risk. Study Design: Case-control study; Level of evidence, 3. Methods: Recreational runners (N = 848) were tested on an instrumented treadmill at their preferred running speed in randomly allocated, standardized running shoes (with either hard or soft cushioning). Typical kinetic and spatiotemporal metrics were derived from ground-reaction force recordings. Participants were subsequently followed up for 6 months regarding running activity and injury. Cox regression models for competing risk were used to investigate the association between biomechanical risk factors and injury risk, including stratified analyses by shoe version. Results: In the crude analysis, greater injury risk was found for greater step length (subhazard rate ratio [SHR], 1.01; 95% CI, 1.00-1.02; P = .038), longer flight time (SHR, 1.00; 95% CI, 1.00-1.01; P = .028), shorter contact time (SHR, 0.99; 95% CI, 0.99-1.00; P = .030), and lower duty factor (defined as the ratio between contact time and stride time; SHR, 0.95; 95% CI, 0.91-0.98; P = .005). In the stratified analyses by shoe version, adjusted for previous injury and running speed, lower duty factor was associated with greater injury risk in those using the soft shoes (SHR, 0.92; 95% CI, 0.85-0.99; P = .042) but not in those using the hard shoes (SHR, 0.97; 95% CI, 0.91-1.04; P = .348). Conclusion: Lower duty factor is an injury risk factor, especially for softer shoe use. Contrary to widespread beliefs, vertical impact peak, loading rate, and step rate were not injury risk factors in recreational runners. Registration: NCT03115437 (ClinicalTrials.gov identifier).
Optimization design of a fully variable valve system based on Nelder-Mead algorithm
Authors: Zheng Cong , Liu Liang , Guo He , Xu Zhaoping 
Published: January 2022

This paper presents an optimal design for the soft-landing of the fully variable valve system in internal combustion engines based on Nelder-Mead algorithm and integrated simulation. The system is used to enhance the engine performance in terms of emissions and fuel economy. The electromagnetic linear actuator (EMLA) and the magnetorheological (MR) buffer are modelled with COMSOL Multiphysics, and a co-simulation platform is constructed with MATLAB/Simulink. The prototype test results are basically consistent with the integrated simulation, indicating the feasibility of the integrated simulation platform. After that, the structure of the magnetorheological buffer is optimized based on the Nelder-Mead algorithm. The optimization objective is the adjustable coefficient and the optimized parameters are the effective length, the annular gap width, the piston diameter, the groove depth and length of the coil. The adjustable coefficient of the optimized MR buffer was increased from 8.8 to 25.46. And the co-simulation results showed that the optimized system has a great improvement in soft-landing performance, with the valve seat velocity reduced from 0.51 m/s to 0.03 m/s and the bounce height reduced from 0.6 mm to nearly 0 when the lift is 8 mm.
A Randomized, Placebo-Controlled Laboratory Classroom Study of the Efficacy and Safety of Dasotraline in Children With ADHD
Authors: Wigal Sharon , Tsai Joyce , Bates John A. , Sarma Kaushik , Tortorich Deidre , Zhu Haiyuan , Goldman Robert 
Published: January 2022

Objective: To evaluate the efficacy of dasotraline 2 mg/day for treatment of ADHD in children weighing ≤30 kg. Method: Children (ages 6–12) with ADHD were randomized to 14 days of once-daily evening doses of dasotraline 2 mg ( n = 47) or placebo ( n = 48). Efficacy was assessed at Baseline and day-15 in seven, 30-minutes classroom sessions on each day (8:00 a.m. to 8:00 p.m.; 12–24 hours post-dose). The primary endpoint was change from Baseline at Day-15 in the Swanson, Kotkin, Agler, M-Flynn, and Pelham (SKAMP) combined score averaged over the seven, serial timepoints. Results: Treatment with dasotraline was associated with significant improvement versus placebo in the primary SKAMP-combined score (least squares mean [ SE] change from Baseline at Day-15: −3.67 [0.775] vs. +1.57 [0.773]; p < .001; effect size, 1.04). Conclusion: Dasotraline 2 mg/day was found to be efficacious and generally well tolerated in this placebo-controlled, laboratory classroom study of children ages 6 to 12 years with ADHD. Clinicaltrials.gov identifier: NCT03231800.
ENhAncing Lifestyle Behaviors in EndometriaL CancEr (ENABLE): A Pilot Randomized Controlled Trial
Authors: Edbrooke Lara , Khaw Pearly , Freimund Alison , Carpenter Danielle , McNally Orla , Joubert Lynette , Loeliger Jenelle , Traill Anya , Gough Karla , Mileshkin Linda , Denehy Linda 
Published: January 2022

Purpose: Endometrial cancer is associated with the highest comorbid disease burden of any cancer. The aim of this trial was to assess the feasibility and safety of an allied health intervention during adjuvant treatment. Methods: A mixed-methods pilot randomized (2:1) controlled trial with concealed allocation and assessor-blinding. Eligibility criteria: adjuvant endometrial cancer treatment scheduled, disease stage I-IIIC1, ECOG 0-2 and able to perform unsupervised physical activity (PA). Participants received usual care and 8 sessions of weekly, individualized, lifestyle education (diet and PA) with behavior change and social support (intervention group), delivered predominantly by telehealth, or usual care alone. Feasibility outcomes: recruitment and consent rates, decline reasons, program acceptability, intervention adherence and retention. Results: 22/44 eligible patients (50%, 95%CI: 36%, 64%) were recruited over 10 months (14 intervention, 8 usual care). The recruitment rate was 2.2 patients/month (95%CI: 1.4, 3.3). Patients who declined had too much going on (7/22, 32%) or were not interested (6/22, 27%). Mean (SD) age and BMI were 63.2 years (6.8) and 31.9 kg/m2 (6.7). A majority were FIGO stage I (15/22, 68%) and received vaginal brachytherapy (14/22, 64%). Adherence was high, 11/14 (79%, 95%CI: 52%, 92%) participants attended >70% of scheduled sessions. Retention was 100% (95%CI: 85%, 100%) at 9 weeks, however completion of objective measures was impacted by COVID-19 restrictions. Telehealth and online questionnaires enabled participation. No serious adverse events occurred. Conclusion: The intervention was acceptable to participants with high levels of adherence and retention. Trial findings will be used to design a future RCT. Trial registration: The trial was registered on www.anzctr.org.au (ACTRN12619000631101) 29/04/2019.
Endovascular treatment of main trunk aneurysms in the residual anterior circulation in moyamoya disease
Authors: Zhou Zibo , Xu Kan , Yu Jinlu 
Published: January 2022

Background Main trunk aneurysms in the residual anterior circulation in moyamoya disease (MMD) are uncommon, and in such cases, endovascular treatment (EVT) is a good choice. Materials and methods A retrospective study was performed on 35 consecutive patients admitted to our hospital who were diagnosed with MMD and main trunk aneurysms in the residual anterior circulation and were treated with EVT. Result The 35 patients were aged 38–77 years (mean, 56.1 ± 8.8 years) and included 17 females (48.6%, 17/35). There were 29 cases (82.9%, 29/35) of hemorrhagic onset. In 35 patients, there were 38 main trunk aneurysms in the residual anterior circulation. Thirty-eight aneurysms underwent coiling; among them, coiling with stent assistance was used in the treatment of 6 (15.8%, 6/38) aneurysms. The immediate modified Raymond-Roy classification (MRRC) was grade I for all aneurysms. Among 35 patients, intraoperative bleeding occurred in 2 (5.7%, 2/35) patients. After EVT, immediate hemiplegia occurred in 4 (11.4%, 4/35) patients, and immediate coma occurred in 1 (2.9%, 1/35) patient. At discharge, in 35 patients, the Glasgow Outcome Scale (GOS) was five in 88.6% of them. Of 35 patients, 68.6% had follow-up data, GOS was five in 87.5% patients, and the MRRC was grade I for all aneurysms in the follow-up angiography. Conclusion For main trunk aneurysms in the residual anterior circulation in MMD, although EVT was accompanied by potential ischemic and hemorrhagic complications, which should be considered, EVT can still offer an acceptable prognosis in more than 85% of patients.
Efficacy and safety of mesenchymal stem cells treatment for multidrug-resistant graft-versus-host disease after haploidentical allogeneic hematopoietic stem cell transplantation
Authors: Shen Meng-Zhu , Liu Xin-Xin , Qiu Zhi-Yuan , Xu Lan-Ping , Zhang Xiao-Hui , Wang Yu , Yan Chen-Hua , Chen Huan , Chen Yu-Hong , Han Wei , Wang Feng-Rong , Wang Jing-Zhi , Liu Si-Ning , Liu Kai-Yan , Huang Xiao-Jun , Mo Xiao-Dong 
Published: January 2022

Purpose: Graft- versus-host disease (GVHD) is an important complication after human leukocyte antigen (HLA) haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT), which may lead to poor prognosis. Our study intends to identify the efficacy and safety of mesenchymal stem cells (MSCs) for multidrug-resistant (MDR)-GVHD after HID HSCT. Methods: MDR-GVHD was referring to GVHD remaining no response to at least two types of therapy, and hUCB-MSCs were given at the dose of (1.0–2.0) × 106/kg once a week. Results: A total of 21 patients were enrolled in this retrospective study (acute GVHD (aGVHD): n = 14, chronic GVHD (cGVHD): n = 7). The median dose of MSCs was 1.2 × 106 cells/kg (range, 0.8–1.8 × 106) cells/kg, and the median numbers of infusion were 2 (range, 1–7) and 3 (range, 2–12) for MDR-aGVHD and MDR-cGVHD patients, respectively. In MDR-aGVHD patients, the overall response rate (ORR) was 57.1%, including 50.0% complete response (CR) and 7.1% partial response (PR), and the median time to response was 49.5 days (range, 16–118) days. The 2-year probability of overall survival after MSCs was 64.3%. Five patients (35.7%) developed infections after MSCs, and no obvious hematologic toxicities were observed. Five MDR-aGVHD patients died after MSCs treatments because of GVHD progression ( n = 1), severe infection (bacterial central nervous system infection: n = 1; fungal pneumonia: n = 2), and poor graft function ( n = 1). In MDR-cGVHD patients, three patients (42.9%) achieved PR after MSCs and the median time to response was 56 days (22–84) days. The ORRs for moderate and severe cGVHD were 50.0% and 33.3%, respectively. Four MDR-cGVHD patients died after MSCs treatments because of GVHD progression ( n = 2), severe fungal pneumonia ( n = 1), and relapse ( n = 1). Conclusion: MSCs treatment may be safe and effective for MDR-GVHD after HID HSCT.
Seasonal variation in paediatric orthopaedic trauma Patients – A single centre experience from Turkey
Authors: Agar Anil , Sahin Adem , Gunes Orhan , Gulabi Deniz , Erturk Cemil 
Published: January 2022

Purpose It is known that the incidence of paediatric orthopaedic trauma peaks in the summer months as a result of increased and uncontrolled physical activity. The aim of this study was to review the experience of a single centre with paediatric orthopaedic traumas and determine the relationship between the severity and the variations in the incidence of traumas in relation to the seasons and temperatures during the study period. Materials and Methods A single institutional review of the historical data of all patients aged 0–16 years who presented for orthopaedic trauma between January 2018 and December 2020 in the emergency department of Level 1 tertiary orthopaedic trauma centre was conducted. 65,182 paediatric orthopaedic trauma cases had been retrieved from the hospital data base during the 3 -year study period. We classified the traumas according to the variants of the patients’ and by holidays, seasons, school days and weekends, months and in which part of the body it occurred. Results After excluding the summer vacation, 77% of paediatric orthopaedic trauma patients attended to the hospital on weekdays and 23% on weekends. While it was observed that hot weather had a statistically positive effect on trauma attendance, rainy weather had an negative effect ( p < 0.05). Trauma attendances were found to be statistically higher in summer months, except for injuries that may occur with indoor activities such as metacarpal fracture, phalanx fracture and pulled elbow ( p < 0.05). Conclusion Orthopaedic trauma at a Level 1 tertiary health care trauma center do vary significantly with the weather and are highest in the summer season. Therefore, it should focus more attention on preventive strategies for paediatric trauma in the summer season.
CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia
Authors: Bennett Cavan , Lawrence Moyra , Guerrero Jose A. , Stritt Simon , Waller Amie K. , Yan Yahui , Mifsud Richard W. , Ballester-Beltrán Jose , Baig Ayesha , Mueller Annett , Mayer Louisa , Warland James , Penkett Christopher J. , Akbari Parsa , Moreau Thomas , Evans Amanda L. , Mookerjee Souradip , Hoffman Gary J. , Saeb-Parsy Kourosh , Adams David J. , Couzens Amber L. , Bender Markus , Erber Wendy N. , Nieswandt Bernhard , Read Randy J. , Ghevaert Cedric 
Published: January 2022

Abstract
The process of platelet production has so far been understood to be a 2-stage process: megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation, with each phase regulating the peripheral blood platelet count. Proplatelet formation releases into the bloodstream beads-on-a-string preplatelets, which undergo fission into mature platelets. For the first time, we show that preplatelet maturation is a third, tightly regulated, critical process akin to cytokinesis that regulates platelet count. We show that deficiency in cytokine receptor-like factor 3 (CRLF3) in mice leads to an isolated and sustained 25% to 48% reduction in the platelet count without any effect on other blood cell lineages. We show that Crlf3−/− preplatelets have increased microtubule stability, possibly because of increased microtubule glutamylation via the interaction of CRLF3 with key members of the Hippo pathway. Using a mouse model of JAK2 V617F essential thrombocythemia, we show that a lack of CRLF3 leads to long-term lineage-specific normalization of the platelet count. We thereby postulate that targeting CRLF3 has therapeutic potential for treatment of thrombocythemia.
Risk and sustainability: trade-offs and synergies for robust decision making
Authors: Hauschild Michael Z. , McKone Thomas E. , Arnbjerg-Nielsen Karsten , Hald Tine , Nielsen Bo F. , Mabit Stefan E. , Fantke Peter 
Published: January 2022

AbstractDecisions about the development of new marketed technologies or products invariably come with consequences for economy, society and the environment. Environmental and health risk assessment on the one hand and sustainability assessment on the other hand are tools that offer different but complementary information about such consequences. Conflicts or synergies between the two tools may arise when there are trade-offs between considerations of specific risks and safety versus long-term sustainability. There is a compelling case for a combined assessment of both sustainability and risks, also in support of a successful safe and sustainable-by-design (SSbD) approach, but this is not straightforward. We offer a roadmap showing when the two assessment tools should be applied together and how to combine them in a consistent way, to support more robust decision-making. Four alternative approaches are evaluated against six performance criteria to recommend an approach that makes use of the broader and more generic sustainability assessment as a baseline and includes iterative applications of risk and sustainability assessment elements to increase specificity, reliability and relevance of the assessment results. The recommended approach provides a basis for better-informed decisions about technology choices for policy and societal stakeholders.
Using entropy-driven amplifier circuit response to build nonlinear model under the influence of Lévy jump
Authors: Fu Hao , Lv Hui , Zhang Qiang 
Published: January 2022

Abstract
Background
Bioinformatics is a subject produced by the combination of life science and computer science. It mainly uses computer technology to study the laws of biological systems. The design and realization of DNA circuit reaction is one of the important contents of bioinformatics.

Results
In this paper, nonlinear dynamic system model with Lévy jump based on entropy-driven amplifier (EDA) circuit response is studied. Firstly, nonlinear biochemical reaction system model is established based on EDA circuit response. Considering the influence of disturbance factors on the system, nonlinear biochemical reaction system with Lévy jump is built. Secondly, in order to prove that the constructed system conforms to the actual meaning, the existence and uniqueness of the system solution is analyzed. Next, the sufficient conditions for the end and continuation of EDA circuit reaction are certified. Finally, the correctness of the theoretical results is proved by numerical simulation, and the reactivity of THTSignal in EDA circuit under different noise intensity is verified.

Conclusions
In EDA circuit reaction, the intensity of external noise has a significant impact on the system. The end of EDA circuit reaction is closely related to the intensity of Lévy noise, and Lévy jump has a significant impact on the nature of biochemical reaction system.