bluuebunny/crossref_metadata_2025_split huggingface dataset:
Busulfan, fludarabine, and melphalan are effective conditioning for pediatric and young adult patients with myeloid malignancies underdoing matched sibling or alternative donor transplantation
Authors: Truscott Laurel , Pariury Holly , Hanmod Santosh , Davini Monica , de la Maza Michelina , Sapp Lauren N. , Staples Kyleigh , Proytcheva Maria , Katsanis Emmanuel 
Published: November 2022

AbstractBackgroundAllogeneic hematopoietic cell transplantation (allo‐HCT) remains a curative option for patients with high‐risk myeloid malignancies.ProcedureWe present our 10‐year experience (October 2012 to October 2021) of consecutive allo‐HCT in patients with myeloid malignancies treated on the pediatric HCT service and conditioned with myeloablative targeted dose—busulfan (BU), fludarabine (FLU), and melphalan (MEL). Twenty‐three children, adolescents, and young adult patients (CAYA) (median age 15.4 years) with acute myeloid leukemia (AML, n = 17), myelodysplastic syndrome (MDS, n = 4), or chronic myeloid leukemia (CML, n = 2) underwent allo‐HCT post‐BU‐FLU‐MEL. Four patients had treatment‐related AML/MDS. Donor/stem cell source was matched sibling donor (MSD) PBSC (n = 7), matched unrelated donor (MUD) PBSC (n = 2), umbilical cord blood (UCB) (n = 3), or haploidentical‐BMT (n = 11). Risk stratification was low (n = 2), intermediate (n = 15), high (n = 3), and very high risk (n = 1). The two patients with CML had failed tyrosine kinase inhibitor therapies.ResultsWith a median follow‐up of 41.6 months, the relapse rate is only 4.5% with an overall survival (OS) 100%, progression‐free survival (PFS) 95.5%, and graft‐versus‐host‐free‐relapse‐free survival (GRFS) 67.8%. The donor source and the acute graft‐versus‐host disease (GvHD) prophylaxis regimen significantly impacted grade II–IV aGvHD 66.7% versus 19.2% (p = .039) and chronic graft‐versus‐host‐disease (cGvHD) 66.7% versus 0% (p = .002) in the patients receiving MSD or MUD PBSC compared to haplo‐BMT, respectively, resulting in improved GRFS in haplo‐BMT, 83.3% compared to 40% matched donor peripheral blood stem cell transplant (PBSCT) (p = .025).ConclusionsOur results demonstrate that BU‐FLU‐MEL is efficacious conditioning for disease control in young patients with myeloid malignancies undergoing MSD or alternative donor allo‐HCT, but in the setting of PBSC grafts with cyclosporine A‐methotrexate (CSA‐MTX) GvHD prophylaxis, it results in an unacceptably high incidence of GvHD.
Multiconformer transition state theory rate constant and branching ratios for the OH‐initiated reaction of CH3OCF2CHF2 and its primary product, HC(O)OCF2CHF2
Authors: Viegas Luís P. 
Published: November 2022

AbstractObtaining rate constants and branching ratios for the atmospheric degradation of organic compounds is crucial for their environmental assessment and for a deeper understanding of their atmospheric chemistry and reactivity. The theoretical prediction of such quantities is a challenging endeavor that grows with conformational complexity. In this work, we have theoretically calculated the rate constants and branching ratios for the tropospheric OH‐initiated oxidation reactions of the
hydrofluoroether and its primary product, the
fluorinated ester. The calculations were performed with a cost‐effective multiconformer transition state theory protocol employing the recently developed constrained transition state randomization method. The calculated
rate constant lies within the error bars of the recommended experimental value, while the calculated rate coefficient of
represents, to our knowledge, the first determination of this reaction's rate constant. The results provide new insight and elucidate the main mechanistic issues discussed in recent experimental work while they also encourage the use of this protocol in investigations of the tropospheric reactivity of other fluorinated organic compounds.
Difficulty in central venous catheter placement due to congenital partial anomalous pulmonary venous return: A case report
Authors: Ye Ruiling , Jiang Zhengying 
Published: November 2022

AbstractCongenital partial anomalous pulmonary venous return (PAPVR) is rare and present in 0.04%–0.7% of the population. This may pose a significant problem for clinicians performing internal jugular venous catheter placement. This report depicts an abnormal internal jugular venous catheter placement due to a PAPVR to help physicians recognize and deal with variant pulmonary veins.
Breathing‐Driven Self‐Powered Pyroelectric ZnO Integrated Face Mask for Bioprotection
Authors: Kim Moon‐Ju , Song Zhiquan , Lee Chang Kyu , Yun Tae Gyeong , Noh Joo‐Yoon , Park Mi‐Kyung , Yong Dongeun , Kang Min‐Jung , Pyun Jae‐Chul 
Published: November 2022

AbstractRapid spread of infectious diseases is a global threat and has an adverse impact on human health, livelihood, and economic stability, as manifested in the ongoing coronavirus disease 2019 (COVID‐19) pandemic. Even though people wear a face mask as protective equipment, direct disinfection of the pathogens is barely feasible, which thereby urges the development of biocidal agents. Meanwhile, repetitive respiration generates temperature variation wherein the heat is regrettably wasted. Herein, a biocidal ZnO nanorod‐modified paper (ZNR‐paper) composite that is 1) integrated on a face mask, 2) harvests waste breathing‐driven thermal energy, 3) facilitates the pyrocatalytic production of reactive oxygen species (ROS), and ultimately 4) exhibits antibacterial and antiviral performance is proposed. Furthermore, in situ generated compressive/tensile strain of the composite by being attached to a curved mask is investigated for high pyroelectricity. The anisotropic ZNR distortion in the bent composite is verified with changes in ZnO bond lengths and OZnO bond angles in a ZnO4 tetrahedron, resulting in an increased polarization state and possibly contributing to the following pyroelectricity. The enhanced pyroelectric behavior is demonstrated by efficient ROS production and notable bioprotection. This study exploring the pre‐strain effect on the pyroelectricity of ZNR‐paper might provide new insights into the piezo‐/pyroelectric material‐based applications.
Phthalate derivative DEHP disturbs the antiproliferative effect of camptothecin in human lung cancer cells by attenuating DNA damage and activating Akt/NF‐κB signaling pathway
Authors: Urade Ritesh , Chou Chon‐Kit , Chou Han‐Lin , Chen Bing‐Hung , Wang Tsu‐Nai , Tsai Eing‐Mei , Hung Chun‐Tzu , Wu Shyh‐Jong , Chiu Chien‐Chih 
Published: November 2022

AbstractPlasticizers/phthalates play a facilitating role in the development of cancer and help the tumor to grow and metastasize. Camptothecin (CPT) and its derivatives are known to have anticancer properties of inhibiting cell growth, promoting cell apoptosis, and increasing autophagy. Therefore, in this study, we investigated whether the presence of di(2‐ethylhexyl) phthalate (DEHP) could hinder apoptosis and autophagy caused by CPT in non‐small cell lung cancer (NSCLC) cells. We found that DEHP interferes with CPT‐induced apoptosis and autophagy and increases the prosurvival pathway by reducing the DNA damage marker γ‐H2AX and activating the Akt and NF‐κB pathways. Furthermore, we also confirmed that combining DEHP with 3‐MA has additive effects in inhibiting autophagy and apoptosis in NSCLC cells. Taken together, our findings show that DEHP could affect CPT‐induced anticancer treatment and provide evidence to show that DEHP induces chemoresistance in CPT‐based chemotherapy.
Integrating Positive Psychology and the Psychology of Religion and Spirituality: Transcending Coexistence to Potentiate Coevolution
Authors: Davis Edward B. , Worthington Everett L. , Schnitker Sarah A. , Glowiak Kevin J. , Lemke Austin W. , Hamilton Chase 
Published: November 2022

AbstractThis chapter sets the stage for the Handbook of Positive Psychology, Religion, and Spirituality. First, we examine the cumulative growth of the positive psychology and psychology of religion/spirituality (R/S) fields, including their degree of existing overlap and their typical publication outlets. Next, we discuss why enhanced integration of these fields would be mutually beneficial and would potentiate their coevolution toward greater scientific and societal impact. Then we acknowledge potential barriers to the integration of these fields and offer recommendations for transcending those barriers. Finally, we preview the organization of this handbook and make suggestions to guide reading it.
Positive Psychology and Judaism
Authors: Schiffman Mark , Cherniak Aaron , Schnall Eliezer , Brooks Suzanne , Pirutinsky Steven , Shabtai Devora 
Published: November 2022

AbstractMany core tenets of positive psychology and the psychology of religion/spirituality (R/S) are essential concepts within the rich literature and culture of the Jewish tradition. Judaism, with its long history of texts, traditions, and practices, can substantively contribute to the developing field of positive psychology. In this chapter, we explore happiness, character, and spirituality within a Judaic framework, opening opportunities for integrative theory, research, and clinical practice. From a theoretical standpoint, these Judaic models provide useful ways of conceptualizing positive psychology constructs. On a pragmatic level, researchers and practitioners can utilize these ideas in their work with the Jewish population, enhancing their efficacy and cultural competence. The chapter includes a general description of Jewish tradition and relevant demographics for context and then summarizes the theory, research, and practice of happiness, character, and spirituality, noting practical suggestions and future directions.
The Scientific Study of Positive Psychology, Religion/Spirituality, and Mental Health
Authors: Shafranske Edward P. 
Published: November 2022

AbstractIn the past 20 years, over 11,000 published articles have examined the relationship between religion and spirituality (R/S) and mental health. This chapter summarizes that literature, drawing on recent meta-analyses and narrative reviews while focusing on mood, anxiety, and trauma-related disorders. Complex associations exist between R/S and mental health, with the preponderance of the research suggesting generally modest, positive effects. The impacts of religious/spiritual involvement, meaning making, religious coping, and spiritual struggles are considered. Following this review, the psychological processes in R/S are examined from the perspective of positive psychology. The interrelated contributions of positive emotion, virtues, and meaning making are identified as essential aspects of R/S that promote well-being and are associated with mental health. Commonalities between religion and spirituality are found in their capacities to evoke positive emotions, support meaning making, and foster the cultivation of virtues. The intersections between secular (positive psychology) and sacred (religious/spiritual) pathways to mental health are highlighted, an integrative conceptual model is proposed, and recommendations for future research are offered.
The Scientific Study of Religion/Spirituality, Forgiveness, and Hope
Authors: Washington-Nortey Melissa , Worthington Everett L. , Ahmed Rihana 
Published: November 2022

AbstractWithin both positive psychology and the psychology of religion and spirituality (R/S), forgiveness and hope are considered key virtues or character strengths. When relationships are beset by transgressions, engaging in forgiveness is related to hope that the relationship is repairable. When people participate in forgiveness interventions, they increase their hope. There are religious and spiritual, empirical, and theoretical reasons why forgiveness and hope are interrelated. We explore these reasons using an evidence-based theoretical model of forgiveness and relational spirituality, which is at the intersection of positive psychology and the psychology of R/S. The forgiveness and relational spirituality model combines basic and intervention research to conceptualize how R/S is related to forgiving. The model posits a sacred dimension to the interrelationships among the victim, offender, and transgression, which are embedded in a particular forgiveness-relevant event. We incorporate hope into this theoretical model and review recent scientific research (2012–2020) on hope, forgiveness, and R/S conjointly (k = 27) and on forgiveness and R/S specifically (k = 72). Almost all this research has been cross-sectional and correlational. We hypothesize causal connections to guide future research and propose ways to guide practitioners as they help people navigate relational forgiveness with more hope.
On the Integration of Positive Psychology and the Psychology of Religion/Spirituality: Logical, Normative, and Methodological Questions
Authors: Porter Steven L. , Baehr Jason , Porter Tenelle , Roberts Robert C. 
Published: November 2022

AbstractWhen it comes to the integration of positive psychology and the psychology of religion/spirituality (R/S), there are three second-order, philosophical questions that need answering: Can these two fields be integrated? Should these two fields be integrated? And, if so, how is it best to integrate these two fields? Although this chapter touches on the logical and normative questions, it is the third, methodological question that receives the greatest attention. We argue that although, from a philosophical perspective, there are no methodological barriers to integrating these two subfields, there is a methodological bonanza in their integration. The golden opportunity is for integrative researchers to abandon a methodological exclusivism that privileges the research methods of the natural sciences in favor of a methodological pluralism that critically engages the philosophical schools and religious/spiritual traditions within which features of human well-being and religious/spiritual life are located. This more eclectic epistemology will provide a broader evidential basis for integrative conclusions and will help connect those conclusions to the realities and complexities of human lives.
Future Directions for the Positive Psychology of Religion and Spirituality
Authors: Davis Edward B. , Schnitker Sarah A. , Worthington Everett L. , Lacey Ethan K. 
Published: November 2022

AbstractIn this chapter, we synthesize the content of this Handbook and call for scientists and practitioners to devote focused attention to the intersections of positive psychology, religion, and spirituality. First, we summarize key themes from the Handbook’s sections and chapters. We highlight deficiencies that are currently inhibiting progress at the intersections of positive psychology and the psychology of religion and spirituality. Finally, to address these deficiencies, we conclude the Handbook by proposing an integrated field—the positive psychology of religion and spirituality—and then offer a prospectus for guiding science and practice in this unified field.
The Netherlands as a Country of Immigration
Authors: Jennissen Roel , Bovens Mark , Engbersen Godfried , Bokhorst Meike 
Published: November 2022

AbstractMigration is leaving its mark on Dutch society. The Netherlands may not be a ‘nation of immigrants’ like Australia, the United States or Canada, where the majority of people are descended from migrants or have a migrant background themselves. But it is a ‘country of immigration’. Approximately one person in four was born abroad or has at least one parent who was. We begin this chapter by sketching four current trends in this respect.
Societal Challenges
Authors: Jennissen Roel , Bovens Mark , Engbersen Godfried , Bokhorst Meike 
Published: November 2022

AbstractThis chapter examines the challenges facing Dutch society once migrants have settled here. Their great diversity by origin makes it complicated to live side by side in neighbourhoods or communities, which can lead to feelings of loss, unease and insecurity. In this chapter we outline the most important findings in this area from our previous empirical research, as well as presenting new ones concerning the local impact of high levels of transient migration. The nature and scale of these challenges, especially those around social cohesion and labour-market participation, differ substantially from place to place. We therefore pay particular attention to that variety.
Reassessing the Policy Agenda
Authors: Jennissen Roel , Bovens Mark , Engbersen Godfried , Bokhorst Meike 
Published: November 2022

AbstractThe Dutch government must pursue a more active policy to familiarize all new migrants with our society and to incorporate them into it as effectively as possible. That is the main message of this publication. In recent decades, policy in this area has been too variable and too reactive. An active policy is necessary because migration to the Netherlands is structural in nature. The Netherlands is now a dynamic migration society, attracting people from all parts of the world. As a result, its diversity by origin is increasing. In addition, we have to deal with more and more transient migration: many immigrants who come to the Netherlands are just ‘passing through’ and so eventually leave again.
Inhibition of mitochondrial respiration by general anesthetic drugs
Authors: Fedorov Anton , Lehto Alina , Klein Jochen 
Published: November 2022

AbstractGeneral anesthetic drugs have been associated with various unwanted effects including an interference with mitochondrial function. We had previously observed increases of lactate formation in the mouse brain during anesthesia with volatile anesthetic agents. In the present work, we used mitochondria that were freshly isolated from mouse brain to test mitochondrial respiration and ATP synthesis in the presence of six common anesthetic drugs. The volatile anesthetics isoflurane, halothane, and (to a lesser extent) sevoflurane caused an inhibition of complex I of the electron transport chain in a dose-dependent manner. Significant effects were seen at concentrations that are reached under clinical conditions (< 0.5 mM). Pentobarbital and propofol also inhibited complex I but at concentrations that were two-fold higher than clinical EC50 values. Only propofol caused an inhibition of complex II. Complex IV respiration was not affected by either agent. Ketamine did not affect mitochondrial respiration. Similarly, all anesthetic agents except ketamine suppressed ATP production at high concentrations. Only halothane increased cytochrome c release indicating damage of the mitochondrial membrane. In summary, volatile general anesthetic agents as well as pentobarbital and propofol dose-dependently inhibit mitochondrial respiration. This action may contribute to depressive actions of the drugs in the brain.
A tensor-based approach to cause-of-death mortality modeling
Authors: Cardillo Giovanni , Giordani Paolo , Levantesi Susanna , Nigri Andrea 
Published: November 2022

AbstractIn various situations, a researcher analyses data stored in a matrix. Often, the information is replicated on different occasions that can be time-varying or refer to different conditions. In these situations, data can be stored in a multi-way array or tensor. In this work, using the Tucker4 model, we apply a tensor-based approach to the mortality by cause of death, hence considering data stored in a four-dimensional array. The dataset here considered is provided by the World Health Organization and refers to causes of death, ages, years, and countries. A deep understanding of changing mortality patterns is fundamental for planning public policies. Knowledge about mortality trends by causes of death and countries can help Governments manage their health care costs and financial planning, including public pensions, and social security schemes. Our analysis reveals that the Tucker4 model allows for extracting meaningful demographic insights, which are useful to understand that the rise in survival during the twentieth century was mostly determined by a reduction of the main causes of death.
FiSH: fair spatial hot spots
Authors: P. Deepak , Sundaram Sowmya S. 
Published: November 2022

AbstractPervasiveness of tracking devices and enhanced availability of spatially located data has deepened interest in using them for various policy interventions, through computational data analysis tasks such as spatial hot spot detection. In this paper, we consider, for the first time to our best knowledge, fairness in detecting spatial hot spots. We motivate the need for ensuring fairness through statistical parity over the collective population covered across chosen hot spots. We then characterize the task of identifying a diverse set of solutions in the noteworthiness-fairness trade-off spectrum, to empower the user to choose a trade-off justified by the policy domain. Being a novel task formulation, we also develop a suite of evaluation metrics for fair hot spots, motivated by the need to evaluate pertinent aspects of the task. We illustrate the computational infeasibility of identifying fair hot spots using naive and/or direct approaches and devise a method, codenamed FiSH, for efficiently identifying high-quality, fair and diverse sets of spatial hot spots. FiSH traverses the tree-structured search space using heuristics that guide it towards identifying noteworthy and fair sets of spatial hot spots. Through an extensive empirical analysis over a real-world dataset from the domain of human development, we illustrate that FiSH generates high-quality solutions at fast response times. Towards assessing the relevance of FiSH in real-world context, we also provide a detailed discussion of how it could fit within the current practice of hot spots policing, as read within the historical context of the evolution of the practice.
Social Presence and Social Facilitation in Gambling: Some Comments on Yokomitsu et al. (2022)
Authors: Griffiths Mark D. 
Published: November 2022

AbstractThis brief commentary adds to the recent study by paper by Yokomitsu, Kono and Takada (2022). Their study examined social presence in gambling by experimentally investigating the effects of the presence of other people on risky betting among high-risk gamblers. This commentary argues that the paper by Yokomitsu et al. provided a highly selective review on available studies and omitted many of the key studies in the area of social presence and social facilitation in which their findings could have been compared. The commentary also briefly outlines a number of studies that have I co-authored in this area over the past three decades using a variety of different methodologies (e.g., non-participant observation studies, experiments, data mining of account-based tracking data), none of which were mentioned by Yokomitsu et al. despite their clear relevance to this area.