bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analgesic Effect of Topical Piroxicam vs Phytotherapy Gel in the Treatment of Acute Soft Tissue Injuries: A Randomized Controlled Noninferiority Study
Authors: Bel haj ali Khaoula , Sekma Adel , Ben Abdallah Saoussen , Yaakoubi Hajer , Trabelsi Imen , Frikha Nourzed , Ben Soltane Houda , Grissa Mohamed Habib , Boubaker Hamdi , Msolli Mohamed Amine , Mezgar Zied , Beltaief Kaouthar , Boukef Riadh , Nouira Semir 
Published: November 2022

Abstract

Objective
The study compared the efficacy and tolerability of piroxicam gel and a new topical combination of medicinal plant products (Soulagel®; Belpharma Tunisia) to treat pain caused by soft tissue injuries.

Methods
Patients (n = 1,525) were assigned to receive piroxicam gel or Soulagel. Efficacy assessments included a change of at least 50% in the pain-on-movement visual numeric scale rating from emergency department discharge (baseline) to day 7 final assessment, as well as the time required to reach pain resolution criteria, the need for rescue analgesia, patients’ satisfaction, and the rate of adverse effects.

Results
At day 7, 1,216 patients (79.7%) achieved at least 50% reduction in visual numeric scale rating from baseline: 623 patients (82.4%) in the Soulagel group vs 593 patients (77.1%) in the piroxicam group (P = 0.01). Time to decrease pain on movement by 50% was significantly higher with piroxicam gel than with Soulagel (34 ± 1 vs 33 ± 1 days, respectively; P = 0.54). At day 7, 96.4% of patients in the Soulagel group declared being “very satisfied” to “satisfied,” vs 68% in the piroxicam group (P &lt; 0.001). There were no major adverse events in either group.

Conclusions
Soulagel is not inferior to piroxicam gel for managing pain related to a soft tissue injuries. Further studies will help ascertain whether this new gel offers an alternative treatment option for this common emergency department condition.
Surveillance as the Past and Future of Public Administration
Authors: Yates Jeff , Whitford Andrew B 
Published: November 2022

AbstractWe trace how privacy-encroaching technologies have unfolded over the course of human history and how such technologies have influenced human societies and economies; governments have been central to this evolution. We maintain that surveillance is inevitable: that the future of public administration will depend on how administrators and others navigate deep rifts in public fear (yet acceptance) of surveillance and other means of data collection. Finally, we argue for coordination among governance scholars, public administrators, public technologists, and civil society advocates in order to improve the institutions that govern the collection and use of data from surveillance activities.
Explaining Backlash: Social Hierarchy and Men’s Rejection of Women’s Rights Reforms
Authors: Benstead Lindsay J , Muriaas Ragnhild , Wang Vibeke 
Published: November 2022

AbstractGovernments promote gender-sensitive policies, yet little is known about why reform campaigns evoke backlash. Drawing on social position theory, we test whether marginalized (women’s organizations) or intrusive (Western donors) messengers cause resistance across public rights (quotas) and private rights (land reform). Using a framing experiment implemented among 1,704 Malawians, we find that females’ attitudes are unaffected by campaigns, while backlash occurs among patrilineal and matrilineal males. Backlash among men is more common for sensitive private rights (land reform) than public rights (quotas) and Western donors than women’s organizations, suggesting complex effects generally more consistent with the intrusiveness hypothesis.
The Diagnosis of Developmental Dysplasia of the Hip From Hip Ultrasonography Images With Deep Learning Methods
Authors: Atalar Hakan , Üreten Kemal , Tokdemir Gül , Tolunay Tolga , Çiçeklidağ Murat , Atik Osman Şahap 
Published: November 2022

Background:
Hip ultrasonography is very important in the early diagnosis of developmental dysplasia of the hip. The application of deep learning-based medical image analysis to computer-aided diagnosis has the potential to provide decision-making support to clinicians and improve the accuracy and efficiency of various diagnostic and treatment processes. This has encouraged new research and development efforts in computer-aided diagnosis. The aim of this study was to evaluate hip sonograms using computer-assisted deep-learning methods.

Methods:
The study included 376 sonograms evaluated as normal according to the Graf method, 541 images with dysplasia and 365 images with incorrect probe position. To classify the developmental hip dysplasia ultrasound images, transfer learning was applied with pretrained VGG-16, ResNet-101, MobileNetV2 and GoogLeNet networks. The performances of the networks were evaluated with the performance parameters of accuracy, sensitivity, specificity, precision, F1 score, and AUC (area under the ROC curve).

Results:
The accuracy, sensitivity, specificity, precision, F1 score, and AUC results obtained by testing the VGG-16, ResNet-101, MobileNetV2, and GoogLeNet models showed performance >80%. With the pretrained VGG-19 model, 93%, 93.5%, 96.7%, 92.3%, 92.6%, and 0.99 accuracy, sensitivity, specificity, precision, F1 score, and AUC results were obtained, respectively.

Conclusion:
In this study, in addition to the ultrasonography images of dysplastic and healthy hips, images were also included of probe malpositioning, and these images were able to be successfully evaluated with deep learning methods. On the sonograms, which provided criteria appropriate for evaluation, successful differentiation could be made of healthy hips and dysplastic hips.

Level of Evidence:
Level-IV; diagnostic studies.
Experiences and Perspectives on Stressors and Organizational Strategies to Bolster Resiliency During the COVID-19 Pandemic
Authors: Khalil Carine , Berdahl Carl T. , Simon Kevin , Uphold Heatherlun , Ghandehari Sara , Durra Omar , Glenn Clarence , Kim Linda , Yumul Roya , Milam Adam Jeraldo 
Published: November 2022

Objective:This qualitative study included a sample of health care workers (HCWs) at a tertiary care center providing direct care to patients with COVID-19 to explore experiences and perceptions regarding care delivery during the COVID-19 pandemic as well as factors that helped HCWs cope with the challenges of the pandemic.Methods:Grounded theory methodology was used to conduct virtual focus groups with a semistructured interview guide May to June 2020.Results:We identified major themes related to (1) HCWs' emotions during the pandemic, (2) the perceived triggers of these feelings, (3) organizational factors that made HCWs feel more supported and appreciated, and (4) personal factors that helped HCWs cope with the pandemic.Conclusion:Results highlighted the stress and challenges associated with exposure to SARS-CoV-2. The findings can help inform interventions to support HCWs during pandemics and other crises.
Posttherapy technetium-99m pentavalent dimercaptosuccinic acid brain single-photon emission computed tomography/computed tomography: diagnostic and prognostic values in patients with glioma
Authors: Mohamadien Nsreen R.A. , Diab Waleed A. , Abd El-Ghani Wael M.A. , Abdelhafez Yasser G. 
Published: November 2022

Purpose
To assess the value of posttherapy 99mTc-pentavalent dimercaptosuccinic acid (DMSA-V) brain SPECT/CT in patients with brain glioma.

Methods
Patients with pathologically or radiologically proven glioma were prospectively enrolled in this study. 99mTc-DMSA-V brain SPECT/CT images were acquired at 120–180 min after i.v. injection of 555–740 MBq of 99mTc-DMSA-V. Three nuclear medicine physicians blindly interpreted the scans visually as positive or negative for residual/recurrent disease. Agreement between two or more readers was considered a consensus. The composite reference standard was considered based on subsequent clinical/neuroimaging follow-up or histopathology whenever available. Overall survival (OS) was calculated from the date of initial diagnosis till the death or the date of last follow-up.

Results
Thirty-four patients (18 males and 16 females; mean age 37.7 ± 16 years) were enrolled in this study. Interreader agreement between the readers ranged from 0.71 to 0.82. Based on the composite reference standard, residual/recurrent disease was confirmed in 16 patients, whereas 18 patients were negative for disease. Consensus reading of 99mTc-DMSA-V SPECT/CT accurately diagnosed 13 true positive (sensitivity 81%) and 17 true negative scans (specificity 94%). After a median follow-up of 22.9 months, 7/14 patients with positive 99mTc-DMSA-V SPECT/CT brain readings died compared to 4/20 with negative readings. The median survival was 24.1 months for the positive group and was not reached for the negative group.

Conclusion
Posttherapy brain SPECT/CT scanning with 99mTc-DMSA-V is a noninvasive, reliable, and specific tool for evaluation of patients with brain glioma after definitive therapy. Scan positivity was associated with poor OS.
The prognostic relationship of 18F-FDG PET/CT metabolic and volumetric parameters in metastatic ALK + NSCLC
Authors: Agüloğlu Nurşin , Aksu Ayşegül , Unat Damla S. , Akyol Murat 
Published: November 2022

Objective
The aim of this study is to determine the role of metabolic and volumetric parameters obtained from 18Fluorine-Fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) imaging on progression-free survival (PFS) and overall survival (OS) in patients with advanced nonsquamous cell lung carcinoma (NSCLC) with anaplastic lymphoma kinase (ALK) rearrangement.

Methods
Pre and post-treatment PET/CT images of the ALK + NSCLC patients between January 2015 and July 2020 were evaluated. The highest standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values were obtained from pre-tyrosine kinase inhibitor (TKI) basal PET/CT (PETpre) and post-TKI PET/CT (PETpost) images. Total MTV (tMTV) and total TLG (tTLG) values were calculated by summing MTV and TLG values in all tumor foci. The change (Δ) in pSUVmax, pMTV, pTLG, tMTV and tTLG before and after treatment was calculated.The relationship of these parameters with OS and PFS was analyzed.

Results
tTLGpre, tMTVpre, pTLGpre, pMTVpre, ∆SUVmax, ∆tMTV and ∆tTLG values were found to be associated with OS; ∆tMTV, ∆tTLG, tTLGpre, tMTVpre, pTLGpre and pMTVpre were associated with PFS. The cutoff values in both predicting OS and PFS were calculated as −31.6 and 391.1 for ∆tMTV and tTLGpre, respectively. In Cox regression analysis, ∆tMTV and stage for OS and ∆tMTV and tTLGpre for PFS were obtained as prognostic factors.

Conclusions
Metabolic and volumetric parameters, especially TLG values in the whole body before treatment and change in whole body MTV value, obtained from PET/CT may be useful in predicting prognosis and determining treatment strategies for patients with advanced ALK + NSCLC.
Recent lipoprotein(a) trials
Authors: Wei Trent , Cho Leslie 
Published: November 2022

Purpose of review
Lipoprotein(a) (Lp(a)) is a genetically determined independent risk factor for cardiovascular disease and calcific aortic stenosis; thus, serum levels are minimally affected by conventional treatments for hypercholesterolemia and hypertriglyceridemia. New RNA therapies directly targeting Lp(a) have demonstrated efficacy in decreasing serum levels. Several recent trials have demonstrated efficacy and safety of these RNA therapeutics.

Recent findings
Single-stranded antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) are two classes of RNA-targeted therapeutics that specifically target the LPA gene, which encodes for apolipoprotein(a), a dominant and rate-limiting component in the hepatic synthesis of Lp(a) particle. Pelacarsen (ASO), olpasiran (siRNA) and SLN360 (siRNA) are novel drugs that have demonstrated efficacy in lowering Lp(a) levels and excellent safety profiles.

Summary
Lp(a) is an independent risk factor for cardiovascular disease. RNA-directed therapies, pelacarsen, olpasiran and SLN360, have shown efficacy in dramatically lowering serum Lp(a) levels. Outcomes data will be the next frontier of Lp(a) trials.
Sharp-Pointed Foreign Body Ingestion in Pediatric Age
Authors: Quitadamo Paolo , Battagliere Ilaria , Del Bene Margherita , Caruso Flora , Gragnaniello Piergiorgio , Dolce Pasquale , Caldore Mariano , Bucci Cristina 
Published: November 2022

Objectives:To assess the clinical complications reported after the ingestion of sharp/pointed foreign bodies (FBs) in pediatric age, their incidence among all FB ingestions, and the features and clinical presentation of children.Study design:We have recruited all consecutive patients aged 0–14 years, admitted for sharp/pointed FB ingestion. Clinical data until hospital discharge were accurately recorded, including both children with esophagogastric FB retention who underwent endoscopic removal and children who were radiologically followed-up till spontaneous FB expulsion. Clinical outcomes were recorded for each patient, with special reference to possible prolonged retention and wall perforation during the intestinal passage.Results:We have enrolled 580 children (males/females: 292/288; age range: 11–180 months; mean age ± standard deviation: 50.5 ± 42 months). Sharp/pointed FBs mainly included fragments of metal 270 of 580 (46.55%) and glass 180 of 580 (31%). FBs were endoscopically removed in 79 of 580 (13.6%) children whereas the remaining FBs passed through the gastrointestinal tract over an overall mean time of 29 hours. No cases of intestinal perforation nor prolonged retention were observed. In 3 of 65 (4.6%) procedures the endoscopist faced an uncomfortable endoscopic removal due to the shape and size of the FB which hampered the retrograde passage through the esophageal sphincters.Conclusions:Our original and extensive data emphasize that accidental ingestion of sharp/pointed FB ingestion is a current issue in pediatric age, especially in toddlers. Metal and glass objects are the most involved FBs and their endoscopic retrieval may not be easy in about 5% of cases. Fortunately, in our pediatric sample no surgical intervention was needed.
Novel approaches to the prediction and diagnosis of pulmonary complications in the paediatric haematopoietic stem cell transplant patient
Authors: Walker Hannah , Shanthikumar Shivanthan , Cole Theresa , Neeland Melanie , Hanna Diane , Haeusler Gabrielle M. 
Published: November 2022

Purpose of review
Haematopoietic stem cell transplant (HSCT) remains the only curative treatment option for many children with relapsed leukaemia, primary immunodeficiencies and haemoglobinopathies. Unfortunately, infectious and noninfectious pulmonary complications following HSCT continue to cause significant morbidity and mortality. This review will focus on recent advances in the field that enhance clinically available diagnostic tools and the role of novel diagnostic techniques.

Recent findings
Research continues to highlight the role of standard diagnostic modalities, including imaging using computed topography chest and Fluorodeoxyglucose-positron emission tomography (FDG-PET) in the diagnosis of posttransplant pulmonary infections. Similarly, bronchoalveolar lavage using bronchoscopy to obtain samples for microbiological analysis remains an important tool in the clinical and diagnostic algorithm for these children. The application of more novel diagnostic techniques such as metagenomic next-generation sequencing and the use of specific biomarkers remain potential future tools in children in whom the aetiology of posttransplant lung disease is unknown. The impact of the pulmonary microbiome on infectious and noninfectious pulmonary disease post HSCT is a future research direction.

Summary
Pulmonary infectious complications post HSCT remain a devastating complication for children and their families. Despite improvements in standard and novel diagnostic modalities, the aetiology of pulmonary disease remains unknown for many patients. There is an urgent need for ongoing collaborative research to bridge this critical knowledge gap and lead to better patient outcomes.
A Quality Improvement Project to Decrease CLABSIs in Non-ICU Settings
Authors: Engel Jill , Meyer Britt M. , McNeil Gloria Alston , Hicks Tammi , Bhandari Kalpana , Hatch Daniel , Granger Bradi B. , Reynolds Staci S. 
Published: November 2022

Background and Objectives:
Central line–associated bloodstream infections (CLABSIs) are a common, preventable healthcare–associated infection. In our 3-hospital health system, CLABSI rates in non-intensive care unit (ICU) settings were above the internal target rate of zero. A robust quality improvement (QI) project to reduce non-ICU CLABSIs was undertaken by a team of Doctor of Nursing Practice (DNP)-prepared nurse leaders enrolled in a post-DNP Quality Implementation Scholars program and 2 QI experts. Based on a review of the literature and local root cause analyses, the QI team implemented the evidence-based practice of using 2% chlorhexidine gluconate (CHG) cloths for daily bathing for non-ICU patients with a central line.

Methods:
A pre-post-design was used for this QI study. CHG bathing was implemented using multifaceted educational strategies that included an e-learning module, printed educational materials, educational outreach, engagement of unit-based CLABSI champions, and an electronic reminder in the electronic health record. Generalized linear mixed-effects models were used to assess the change in CLABSI rates before and after implementation of CHG bathing. CLABSI rates were also tracked using statistical process control (SPC) charts to monitor stability over time. CHG bathing documentation compliance was audited as a process measure. These audit data were provided to unit-based leadership (nurse managers and clinical team leaders) on a monthly basis. A Qualtrics survey was also disseminated to nursing leadership to evaluate their satisfaction with the CHG bathing implementation processes.

Results:
Thirty-four non-ICU settings participated in the QI study, including general medical/surgical units and specialty areas (oncology, neurosciences, cardiac, orthopedic, and pediatrics). While the change in CLABSI rates after the intervention was not statistically significant (b = −0.35, P = .15), there was a clinically significant CLABSI rate reduction of 22.8%. Monitoring the SPC charts demonstrated that CLABSI rates remained stable after the intervention at all 3 hospitals as well as the health system. CHG bathing documentation compliance increased system-wide from 77% (January 2020) to 94% (February 2021). Overall, nurse leaders were satisfied with the CHG bathing implementation process.

Conclusions:
To sustain this practice change in non-ICU settings, booster sessions will be completed at least on an annual basis. This study provides further support for using CHG cloths for daily patient bathing in the non-ICU setting.
Financial Impact of a Culturally Sensitive Hispanic Kidney Transplant Program on Increasing Living Donation
Authors: Wang Andrew , Caicedo Juan Carlos , Mathur Amit K. , Ruiz Richard M. , Gordon Elisa J. 
Published: November 2022

Background.
In the United States, Hispanic/Latinx patients receive disproportionately fewer living donor kidney transplants (LDKTs) than non-Hispanic White patients. Northwestern Medicine’s culturally targeted Hispanic Kidney Transplant Program (HKTP) was found to increase LDKTs in Hispanic patients at 1 of 2 transplant programs with greater implementation fidelity.

Methods.
We conducted a budget impact analysis to evaluate HKTP’s impact on program financial profiles from changes in volume of LDKTs and deceased donor kidney transplants (DDKTs) in 2017 to 2019. We estimated HKTP programmatic costs, and kidney transplant (KT) program costs and revenues. We forecasted transplant volumes, HKTP programmatic costs, and KT program costs and revenues for 2022–2024.

Results.
At both programs, HKTP programmatic costs had <1% impact on total KT program costs, and HKTP programmatic costs comprised <1% of total KT program revenues in 2017–2019. In particular, the total volume of Hispanic KTs and HKTP LDKTs increased at both sites. Annual KT program revenues of HKTP LDKTs and DDKTs increased by 226.9% at site A and by 1042.9% at site B when comparing 2019–2017. Forecasted HKTP LDKT volume showed an increase of 36.4% (site A) and 33.3% (site B) with a subsequent increase in KT program revenues of 42.3% (site A) and 44.3% (site B) among HKTP LDKTs and DDKTs.

Conclusions.
HKTP programmatic costs and KT evaluation costs are potentially recoverable by reimbursement of organ acquisition costs and offset by increases in total KT program revenues of LDKTs; transplant programs may find implementation of the HKTP financially manageable.
Phase angle is related to physical function and quality of life in preoperative patients with lumbar spinal stenosis
Authors: Otsubo Ryota , Hashida Ryuki , Murotani Kenta , Iwanaga Sohei , Hirota Keisuke , Koya Syunji , Tsukada Yuya , Ogata Yuta , Yokosuka Kimiaki , Yoshida Tatsuhiro , Nakae Ichiro , Fudo Takuma , Morito Shinji , Shimazaki Takahiro , Shimogawa Shingo , Yamaryo Reika , Ito Mai , Yamada Kei , Sato Kimiaki , Matsuse Hiroo , Shiba Naoto , Hiraoka Koji 
Published: November 2022

AbstractPurposeLumbar spinal stenosis (LSS) causes various symptoms, which can interfere with daily life and Quality of Life (QOL). Evaluating both patients’ physical function and QOL and helping them to improve is the focus of rehabilitation. Phase angle (PhA) assessment has been widely used to measure body composition, and it has been reported to reflect physical function and QOL. The purpose of this study was to investigate the relationship between PhA and physical function, physical activity, and QOL in patients with LSS.MethodsPhA, handgrip strength, walking speed, timed up and go test (TUG), Life Space Assessment (LSA), Prognostic Nutritional Index (PNI), Japanese Orthopaedic Association back pain evaluation questionnaire (JOABPEQ), and EQ-5D were assessed. Multiple regression analysis was conducted to investigate the relationship of PhA to physical function, physical activity, and QOL using.ResultsStatistical analysis was performed on 104 patients with LSS. The results of multiple regression analysis of PhA adjusted for age, gender, and BMI (Model 1) and PhA adjusted for age, gender, BMI, and PNI (Model 2) compared with physical function and physical activity showed significant correlations respectively (P<0.05) in handgrip strength, walking speed, TUG, and LSA. In QOL assessment, both models showed a significant correlation (P<0.05) with lumbar function in JOABPEQ and a significant trend (P<0.1) in EQ-5D.ConclusionPhA in LSS patients in this study was associated with physical function and QOL, and may be a useful new tool for clinical evaluation in preoperative LSS patients.