bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flexible, non-parametric modeling using regularized neural networks
Authors: Allerbo Oskar , Jörnsten Rebecka 
Published: January 2022

AbstractNon-parametric, additive models are able to capture complex data dependencies in a flexible, yet interpretable way. However, choosing the format of the additive components often requires non-trivial data exploration. Here, as an alternative, we propose PrAda-net, a one-hidden-layer neural network, trained with proximal gradient descent and adaptive lasso. PrAda-net automatically adjusts the size and architecture of the neural network to reflect the complexity and structure of the data. The compact network obtained by PrAda-net can be translated to additive model components, making it suitable for non-parametric statistical modelling with automatic model selection. We demonstrate PrAda-net on simulated data, where we compare the test error performance, variable importance and variable subset identification properties of PrAda-net to other lasso-based regularization approaches for neural networks. We also apply PrAda-net to the massive U.K. black smoke data set, to demonstrate how PrAda-net can be used to model complex and heterogeneous data with spatial and temporal components. In contrast to classical, statistical non-parametric approaches, PrAda-net requires no preliminary modeling to select the functional forms of the additive components, yet still results in an interpretable model representation.
US lesion visibility predicts clinically significant upgrade of prostate cancer by systematic biopsy
Authors: Velarde Nathan , Westphalen Antonio C. , Nguyen Hao G. , Neuhaus John , Shinohara Katsuto , Simko Jeffry P. , Larson Peder E. , Magudia Kirti 
Published: January 2022

Abstract
Purpose
To identify predictors of when systematic biopsy leads to a higher overall prostate cancer grade compared to targeted biopsy.

Methods and materials
918 consecutive patients who underwent prostate MRI followed by MRI/US fusion biopsy and systematic biopsies from January 2015 to November 2019 at a single academic medical center were retrospectively identified. The outcome was upgrade of PCa by systematic biopsy, defined as cases when systematic biopsy led to a Gleason Grade (GG) ≥ 2 and greater than the maximum GG detected by targeted biopsy. Generalized linear regression and conditional logistic regression were used to analyze predictors of upgrade.

Results
At the gland level, the presence of an US-visible lesion was associated with decreased upgrade (OR 0.64, 95% CI 0.44–0.93, p = 0.02). At the sextant level, upgrade was more likely to occur through the biopsy of sextants with MRI-visible lesions (OR 2.58, 95% CI 1.87–3.63, p < 0.001), US-visible lesions (OR 1.83, 95% CI 1.14–2.93, p = 0.01), and ipsilateral lesions (OR 3.89, 95% CI 2.36–6.42, p < 0.001).

Conclusion
Systematic biopsy is less valuable in patients with an US-visible lesion, and more likely to detect upgrades in sextants with imaging abnormalities. An approach that takes additional samples from regions with imaging abnormalities may provide analogous information to systematic biopsy.
Simulation in Hand Surgery: A Literature Review
Authors: Saleem Humza Y. , Kaplan Jamie L. , Torres‐Guzman Ricardo A. , Avila Francisco R. , Forte Antonio J. 
Published: January 2022

AbstractBackgroundDue to duty hour regulations, patient safety and inadequate operative time simulation have become a necessary part of surgical education and training in residency. Currently, there is no formal adoption of simulators for the use of surgical education or assessment in hand surgery. This literature review analyzes that the simulation techniques established thus far in hand surgery.MethodsA comprehensive literature search was performed on PubMed. Search results were filtered by title and abstract to isolate articles that were relevant to simulation in hand surgery. Articles that were nonspecific to the hand, non‐English and cadaveric were excluded. Additional articles were identified through references from the initial search.ResultsA total of 1192 articles were yielded from the initial query. After the application of the inclusion criteria, this was narrowed down to 28 articles. Another 8 additional articles were excluded as they did not pertain to the hand although the simulators could be adapted for hand surgery. A total of 20 articles were included in this study.ConclusionsSurgical simulation is a growing and essential field of surgical education. Simulators in hand surgery are limited and require further research and validation. Like other surgical subspecialties, hand surgery may benefit from the adoption of an official simulation curriculum for the assessment of residents and enhancement of technical skills.
Accurate Nodal Staging in Pancreatic Cancer in the Era of Neoadjuvant Therapy
Authors: Javed Ammar A. , Ding Ding , Baig Erum , Wright Michael J. , Teinor Jonathan A. , Mansoor Daniyal , Thompson Elizabeth , Hruban Ralph H. , Narang Amol , Burns William R. , Burkhart Richard A. , Lafaro Kelly , Weiss Matthew J. , Cameron John L. , Wolfgang Christopher L. , He Jin 
Published: January 2022

AbstractBackgroundNodal disease is prognostic in pancreatic ductal adenocarcinoma (PDAC); however, optimal number of examined lymph nodes (ELNs) required to accurately stage nodal disease in the current era of neoadjuvant therapy remains unknown. The aim of the study was to evaluate the optimal number of ELNs in patients with neoadjuvantly treated PDAC.MethodsA retrospective study was performed on patients with PDAC undergoing resection following neoadjuvant treatment between 2011 and 2018. Clinicopathological data were extracted and analyzed.ResultsOf 546 patients included, 232 (42.5%) had lymph node metastases. The median recurrence free survival (RFS) was 10.6 months (95% confidence interval: 9.7–11.7) and nodal disease was independently associated with shorter RFS (9.1 vs 11.9 months; p < 0.001). A cutoff of 22 ELNs was identified that stratified patients by RFS. Patients with N1 and N2 disease had similar median RFS (9.1 vs 8.9 months; p = 0.410). On multivariable analysis, ELN of ≥ 22 was found to be significantly associated with longer RFS among patients with N0 disease (14.2 vs. 10.9 months, p = 0.046). However, ELN has no impact on RFS for patients with N1/N2 disease (9.5 vs. 8.4 months, p = 0.190). Adjuvant therapy was associated with RFS only in patients with residual nodal disease.ConclusionsLymph node metastases remain prognostic in PDAC patients after neoadjuvant treatment. Among N0 patients, a cutoff of 22 ELN was associated with improved RFS and resulted in optimal nodal staging.
Geriatric Trauma in a High‐Volume Trauma Centre in Cape Town: How Do We Compare?
Authors: Breedt Danyca Shadé , Steyn Elmin 
Published: January 2022

AbstractBackgroundLittle is known about the injury profile of older persons from low‐and‐middle‐income countries, such as South Africa, where violence is prevalent. This study aimed to identify common mechanisms of injury (MOI), severity, complications, and outcomes in elderly patients admitted to a referral trauma centre in Cape Town.MethodsA retrospective review was performed of all patients ≥60 years presenting at Tygerberg hospital trauma centre over an eight‐month period. Descriptive statistics were computed for all variables of interest, and the relationship between the MOI, injury severity score (ISS), complications, and outcomes were assessed.ResultsOf the total 7,635 trauma cases admitted, patients ≥60 years accounted for 4% (n = 275). The most frequent MOI was low falls (58%). Of these 11% of injuries were intentionally inflicted. Among them 35% of the patients experienced complications. The ISS was positively associated with the number of complications (p < 0.01). The mortality rate was 6.5%. An ISS of ≥10 was associated with increased mortality (p < 0.01). The number of complications was positively associated with mortality (p < 0.01).ConclusionsIn contrast to high‐income countries (HICs), the cohort of elderly patients admitted to the trauma centre made up a relatively small portion of the total admissions. Compared to HICs, intentionally inflicted injuries and preventable MOI were common in our sample, underscoring the importance of addressing causative factors. Notably, the ISS was strongly associated with the number of complications and an ISS ≥10 was associated with mortality, highlighting the utility of the ISS in identifying elderly trauma patients most at risk of negative outcomes.
Work changes and employee age, maladaptive coping expectations, and well-being: a Swedish cohort study
Authors: Van Vianen Annelies E. M. , Van Laethem Michelle , Leineweber Constanze , Westerlund Hugo 
Published: January 2022

Abstract
Purpose
Older workers are expected to suffer more from work changes than younger ones, but empirical evidence is lacking. Negative responses to work changes may result rather from maladaptive coping expectations. This study examined possible age differences in job and life satisfaction, and sleep disturbances, after work changes (voluntary and involuntary job changes, reorganizations) and the moderating role of maladaptive coping expectations.

Methods
Four biennial waves from the Swedish Longitudinal Occupational Survey of Health (SLOSH) including respondents who participated in all four waves (n = 3084). We used multilevel path analyses to estimate direct and moderated relationships between work changes and outcomes.

Results
Involuntary job changes were associated with lower job and life satisfaction and more sleep disturbances. Reorganizations were only associated with lower job satisfaction. Older employees were more satisfied with their jobs and lives than younger employees and experienced more sleep disturbances. After involuntary job changes, older employees had similar (lower) levels of well-being as younger ones, but they reported more sleep disturbances when having experienced reorganizations. Maladaptive coping expectations were related to lower job and life satisfaction and more sleep disturbances. Employees with maladaptive coping expectations reported more sleep disturbances after involuntary job changes and reorganizations.

Conclusion
Our results suggest that there are few age differences in well-being after work changes. Employee well-being seems to mostly depend on maladaptive coping expectations. Organizations aiming to prepare employees for job changes and reorganizations could focus their efforts on employees with maladaptive expectations rather than on older ones.
Study of the glial cytoarchitecture of the developing olfactory bulb of a shark using immunochemical markers of radial glia
Authors: Docampo-Seara A. , Candal E. , Rodríguez M. A. 
Published: January 2022

AbstractDuring development of the olfactory bulb (OB), glial cells play key roles in axonal guiding/targeting, glomerular formation and synaptic plasticity. Studies in mammals have shown that radial glial cells and peripheral olfactory glia (olfactory ensheathing cells, OECs) are involved in the development of the OB. Most studies about the OB glia were carried out in mammals, but data are lacking in most non-mammalian vertebrates. In the present work, we studied the development of the OB glial system in the cartilaginous fish Scyliorhinus canicula (catshark) using antibodies against glial markers, such as glial fibrillary acidic protein (GFAP), brain lipid-binding protein (BLBP), and glutamine synthase (GS). These glial markers were expressed in cells with radial morphology lining the OB ventricle of embryos and this expression continues in ependymal cells (tanycytes) in early juveniles. Astrocyte-like cells were also observed in the granular layer and surrounding glomeruli. Numerous GS-positive cells were present in the primary olfactory pathway of embryos. In the developmental stages analysed, the olfactory nerve layer and the glomerular layer were the regions with higher GFAP, BLBP and GS immuno-reactivity. In addition, numerous BLBP-expressing cells (a marker of mammalian OECs) showing proliferative activity were present in the olfactory nerve layer. Our findings suggest that glial cells of peripheral and central origin coexist in the OB of catshark embryos and early juveniles. These results open the path for future studies about the differential roles of glial cells in the catshark OB during embryonic development and in adulthood.
Metazoan endoparasite fauna and feeding ecology of commercial fishes from Java, Indonesia
Authors: Koepper Svenja , Nuryati Sri , Palm Harry W. , Wild Christian , Yulianto Irfan , Kleinertz Sonja 
Published: January 2022

AbstractDespite being an important component of the marine ecosystem and posing health risks to human seafood consumers, fish parasites in Indonesia have yet to be adequately described. Here, we analyzed the diet and metazoan parasite fauna of seven commercial fish species (Alectis indica,Carangoides chrysophrys,Johnius borneensis,Mene maculata,Trichiurus lepturus,Upeneus asymmetricus,U. moluccensis) landed in Java, Indonesia. We isolated 11 endoparasite species, established 22 new host and 14 new locality records, and extended parasitological records ofA. indicaby 24%,C. chrysophrysby 25%,J. borneensisby 40%,M. maculataby 44%,U. asymmetricusby 100%, andU. moluccensisby 17%. We genetically identified the trematodeStephanostomumcf.uku(of Bray et al. 2005) fromAlecta indicafor the first time in Indonesia and provided the sequence of its 28S marker. Stomach content analysis revealed seven different prey items, and the examined fish species were grouped into four feeding categories, which differed significantly in their respective endoparasite fauna. All but two examined fish species hosted potentially zoonotic nematodes, which reveal a risk for parasite-borne diseases in Indonesian food fishes and call for more consequent monitoring with regard to seafood safety in this region. With this study, we were able to establish an association between the feeding ecology and the endoparasite fauna of marine fishes which will help to better understand the transmission pathways of (potentially zoonotic) parasites in food fishes in tropical waters.
Genome size variation in Deschampsia cespitosa sensu lato (Poaceae) in Eurasia
Authors: Greimler Josef , Temsch Eva M. , Xue Zhiqing , Weiss-Schneeweiss Hanna , Volkova Polina , Peintinger Markus , Wasowicz Pawel , Shang Hui , Schanzer Ivan , Chiapella Jorge O. 
Published: January 2022

AbstractThe grass Deschampsia cespitosa is a variable taxon out of which many varieties, subspecies and endemic species have been separated. In this paper, the variation in genome size (GS) and ploidy of this grass including several of its subspecies and two related species in Eurasia was investigated by flow cytometric (FCM) measurements. GS and ploidy data were also related to specific environments and reproduction mode. Ploidy levels found by FCM were confirmed by chromosome counts of diploid (2n = 26) and tetraploid (2n = 52) samples. Seminiferous (seed bearing) D. cespitosa was mainly diploid (GS between 3.754 and 5.438 pg/1C). GS variation in diploids showed a geographic pattern with a significant difference (H = 41,441, P < 0.001) between European (median = 4.377 pg) and Asian (median = 4.881 pg) accessions. Genome size (1C) in tetraploids ranged from 7.9426 to 9.0399 pg. Tetraploid seminiferous D. cespitosa was found mostly in disturbed habitats in western and southern Europe, while tetraploids in Asia were registered in wet Arctic habitats. Genome size (1C between 8.3278 and 8.8603 pg) of the pseudoviviparous plants (spikelets produce plantlets asexually) of wet habitats in central and northern Europe indicated tetraploidy. A putative triploid (GS 6.6817 pg) was detected in Iceland. Summing up, we found a high variation in GS on the geographic scale with significant regional differences in diploid D. cespitosa. Among the tetraploids, the asexually reproducing plants were bound to specific habitats, while the seminiferous plants showed a habitat preference similar to the diploids.
On a mixture of an MGT viscous material and an elastic solid
Authors: Fernández José R. , Quintanilla Ramón 
Published: January 2022

AbstractA lot of attention has been paid recently to the study of mixtures and also to the Moore–Gibson–Thompson (MGT) type equations or systems. In fact, the MGT proposition can be used to describe viscoelastic materials. In this paper, we analyze a problem involving a mixture composed by a MGT viscoelastic type material and an elastic solid. To this end, we first derive the system of equations governing the deformations of such material. We give the suitable assumptions to obtain an existence and uniqueness result. The semigroups theory of linear operators is used. The paper concludes by proving the exponential decay of solutions with the help of a characterization of the exponentially stable semigroups of contractions and introducing an extra assumption. The impossibility of location is also shown.
Non-convex nested Benders decomposition
Authors: Füllner Christian , Rebennack Steffen 
Published: January 2022

AbstractWe propose a new decomposition method to solve multistage non-convex mixed-integer (stochastic) nonlinear programming problems (MINLPs). We call this algorithm non-convex nested Benders decomposition (NC-NBD). NC-NBD is based on solving dynamically improved mixed-integer linear outer approximations of the MINLP, obtained by piecewise linear relaxations of nonlinear functions. Those MILPs are solved to global optimality using an enhancement of nested Benders decomposition, in which regularization, dynamically refined binary approximations of the state variables and Lagrangian cut techniques are combined to generate Lipschitz continuous non-convex approximations of the value functions. Those approximations are then used to decide whether the approximating MILP has to be dynamically refined and in order to compute feasible solutions for the original MINLP. We prove that NC-NBD converges to an $$\varepsilon $$
ε
-optimal solution in a finite number of steps. We provide promising computational results for some unit commitment problems of moderate size.
Effect of oxygen on the germination and culturability of Bacillus atrophaeus spores
Authors: Wu Wen Jie , Chang Jinhui 
Published: January 2022

AbstractThe effect of oxygen on the germination and culturability of aerobic Bacillus atrophaeus spores was investigated in this study. Under oxic or anoxic conditions, various nutritional and non-nutritional germinants were utilized to induce germination. Tb3+-dipicolinic acid fluorescence assay and phase-contrast microscopy were used to track the germination process. The final germination level, germination half time, and germination speed were used to define germination kinetics. Colony-forming unit enumeration was used to assess the culturability of germinated spores germinated with or without oxygen. The results show that in the absence of oxygen, the final germination level was unaffected, germination half time decreased by up to 35.0%, germination speed increased by up to 27.4%, and culturability decreased by up to 95.1%. It is suggested that oxygen affects some germinant receptor-dependent germination pathways, implying that biomolecules engaged in these pathways may be oxygen-sensitive. Furthermore, spores that have completed the germination process in either anoxic or oxic conditions may have different culturability. This research contributed to a better understanding of the fundamental mechanism of germination.
Vascular 3D Printing with a Novel Biological Tissue Mimicking Resin for Patient-Specific Procedure Simulations in Interventional Radiology: a Feasibility Study
Authors: Kaufmann R. , Zech C. J. , Takes M. , Brantner P. , Thieringer F. , Deutschmann M. , Hergan K. , Scharinger B. , Hecht S. , Rezar R. , Wernly B. , Meissnitzer M. 
Published: January 2022

AbstractThree-dimensional (3D) printing of vascular structures is of special interest for procedure simulations in Interventional Radiology, but remains due to the complexity of the vascular system and the lack of biological tissue mimicking 3D printing materials a technical challenge. In this study, the technical feasibility, accuracy, and usability of a recently introduced silicone-like resin were evaluated for endovascular procedure simulations and technically compared to a commonly used standard clear resin. Fifty-four vascular models based on twenty-seven consecutive embolization cases were fabricated from preinterventional CT scans and each model was checked for printing success and accuracy by CT-scanning and digital comparison to its original CT data. Median deltas (Δ) of luminal diameters were 0.35 mm for clear and 0.32 mm for flexible resin (216 measurements in total) with no significant differences (p > 0.05). Printing success was 85.2% for standard clear and 81.5% for the novel flexible resin. In conclusion, vascular 3D printing with silicone-like flexible resin was technically feasible and highly accurate. This is the first and largest consecutive case series of 3D-printed embolizations with a novel biological tissue mimicking material and is a promising next step in patient-specific procedure simulations in Interventional Radiology.
Gender differences in the intention to get vaccinated against COVID-19: a systematic review and meta-analysis
Authors: Zintel Stephanie , Flock Charlotte , Arbogast Anna Lisa , Forster Alice , von Wagner Christian , Sieverding Monika 
Published: January 2022

Abstract
Aim
We conducted a systematic review and meta-analysis to analyse gender differences in COVID-19 vaccination intentions.

Subject and methods
PubMed, Web of Science and PsycInfo were searched (November 2020 to January 2021) for studies reporting absolute frequencies of COVID-19 vaccination intentions by gender. Averaged odds ratios comparing vaccination intentions among men and women were computed. Descriptive analyses of the studies were reported.

Results
Sixty studies were included in the review and data from 46 studies (n = 141,550) were available for meta-analysis. A majority (58%) of papers reported men to have higher intentions to get vaccinated against COVID-19. Meta-analytic calculations showed that significantly fewer women stated that they would get vaccinated than men, OR 1.41 (95% CI 1.28 to 1.55). This effect was evident in several countries, and the difference was bigger in samples of health care workers than in unspecified general population samples.

Conclusion
This systematic review and meta-analysis found lower vaccination intentions among women than men. This difference is discussed in the light of recent data on actual vaccination rates in different countries.