bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suppressed phonon conduction by geometrically induced evolution of transport characteristics from Brownian motion into Lévy flight
Authors: Kim Yongjoon , Kodama Takashi , Kim Yoonjin , Kim Brian S. Y. , Ko Changhyun , Lim Jongwoo , Park Woosung 
Published: April 2022

AbstractDespite extensive research on quasi-ballistic phonon transport, anomalous phonon transport is still observed in numerous nanostructures. Herein, we investigate the transport characteristics of two sets of samples: straight beams and nanoladders comprising two straight beams orthogonally connected with bridges. A combination of experiments and analysis with a Boltzmann transport model suggests that the boundary scattering within the bridges considerably dictates the distribution of phonon mean free paths, despite its negligible contribution to the net heat flux. Statistical analysis of those boundary scatterings shows that phonons with large axial angles are filtered into bridges, creating dead spaces in the line-of-sight channels. Such redistribution induces Lévy walk conduction along the line-of-sight channels, causing the remaining phonons within the bridges to exhibit Brownian motion. Phonon conduction in the nanoladders is suppressed below that of the straight beams with equivalent cross-sectional areas due to trapped phonons within the bridges. Our work reveals the origin of unusual thermal conductivity suppression at the nanoscale, suggesting a method to modulate phonon conduction via systematic nanostructuring.
Understanding of cell death induced by the constituents of Taxus yunnanensis wood
Authors: Akao Yukihiro , Terazawa Riyako , Sugito Nobuhiko , Heishima Kazuki , Morikawa Kohei , Ito Yuko , Narui Ryoko , Hamaguchi Reo , Nobukawa Takahiro 
Published: April 2022

AbstractThe ethanol extract from the wood ofTaxus Yunnanensis(TY) induced apoptosis in all cancer cell lines tested, which was mainly due to activation of an extrinsic pathway in human colon cancer DLD-1 cells. The extrinsic pathway was activated by the upregulation of the expression levels of Fas and TRAIL/DR5, which led to the activation of caspase-8. Of note, the machinery of this increase in expression was promoted by the upregulation of MIR32a expression, which silenced MIR34a-targeting E2F3 transcription factor. Furthermore, ectopic expression of MIR32a or siR-E2F3 silencingE2F3increased Fas and TRAIL/DR5 expression. Thus, the extract activated the extrinsic pathway through the MIR34a/E2F3 axis, resulting in the autocrine and paracrine release of TRAIL, and upregulated expression of death receptors Fas and DR5 in the treated DLD-1 cells, which were functionally validated by Fas immunocytochemistry, and using anti-Fas and anti-TRAIL antibodies, respectively. In vivo, TY showed significant anti-tumor effects on xenografted and syngeneic model mice. The extract may also aid in chemoprevention by selectively making marked tumor cells susceptible to the tumor immunosurveillance system.
The demographic and geographic impact of the COVID pandemic in Bulgaria and Eastern Europe in 2020
Authors: Rangachev Antoni , Marinov Georgi K. , Mladenov Mladen 
Published: April 2022

AbstractThe COVID-19 pandemic followed a unique trajectory in Eastern Europe compared to other heavily affected regions, with most countries there only experiencing a major surge of cases and deaths towards the end of 2020 after a relatively uneventful first half of the year. However, the consequences of that surge have not received as much attention as the situation in Western countries. Bulgaria, even though it has been one of the most heavily affected countries, has been one of those neglected cases. We use mortality and mobility data from Eurostat, official governmental and other sources to examine the development and impact of the COVID-19 pandemic in Bulgaria and other European countries. We find a very high level of excess mortality in Eastern European countries measured by several metrics including excess mortality rate (EMR), P-scores, potential years of life lost (PYLL) and its age standardised version (ASYR), and working years of life lost (WYLL). By the last three metrics Eastern Europe emerges as the hardest hit region by the pandemic in Europe in 2020. With a record EMR at ~0.27% and a strikingly large and mostly unique to it mortality rate in the working age (15–64 years) demographics, Bulgaria emerges as one of the most affected countries in Eastern Europe. The high excess mortality in Bulgaria correlates with insufficient intensity of testing, with delayed imposition of “lockdown” measures, and with high prevalence of cardiovascular diseases. We also find major geographic and demographic disparities within the country, with considerably lower mortality observed in major cities relative to more remote areas (likely due to disparities in the availability of medical resources). Analysis of the course of the epidemic revealed that individual mobility measures were predictive of the eventual decline in cases and deaths. However, while mobility declined as a result of the imposition of a lockdown, it already trended downwards before such measures were introduced, which resulted in a reduction of deaths independent of the effect of restrictions. Large excess mortality and high numbers of potential years of life lost are observed as a result of the COVID pandemic in Bulgaria, as well as in several other countries in Eastern Europe. Significant delays in the imposition of stringent mobility-reducing measures combined with a lack of medical resources likely caused a substantial loss of life, including in the working age population.
Assessing the toxicological interaction effects of imidacloprid, thiamethoxam, and chlorpyrifos on Bombus terrestris based on the combination index
Authors: Zhang Yongkui , Zeng Dongqiang , Li Lu , Hong Xiuchun , Li-Byarlay Hongmei , Luo Shudong 
Published: April 2022

AbstractIn modern agricultural production, a variety of pesticides are widely used to protect crops against pests. However, extensive residues of these pesticides in the soil, water, and pollen have negatively affected the health of nontarget organisms, especially among pollinators such as bumblebees. As an important pollinator, the bumblebee plays a vital role in agricultural production and the maintenance of ecosystem diversity. Previous research has focused on the effects of a single pesticide on pollinating insects; however, the synergistic effects of multiple agents on bumblebees have been not studied in detail. Imidacloprid, thiamethoxam, and chlorpyrifos are three of common pesticides known for severe effects on bumblebee health. It is still unknown what synergistic effects of these pesticides on pollinators. In our test, the individual and combined toxicities of chlorpyrifos, thiamethoxam, and imidacloprid to bumblebees after 48 h of oral administration were documented by the equivalent linear equation method. Our results showed that the toxicity of each single pesticide exposure, from high to low, was imidacloprid, thiamethoxam, and chlorpyrifos. All binary and ternary combinations showed synergistic or additive effects. Therefore, our research not only shows that the mixed toxicity of insecticides has a significant effect on bumblebees, but also provides scientific guidelines for assessing the safety risks to bumblebees of these three insecticide compounds. In assessing the risk to pollinating insects, the toxicity levels of laboratory experiments are much lower than the actual toxicity in the field.
89Zr-PET imaging to predict tumor uptake of 177Lu-NNV003 anti-CD37 radioimmunotherapy in mouse models of B cell lymphoma
Authors: Giesen Danique , Hooge Marjolijn N. Lub-de , Nijland Marcel , Heyerdahl Helen , Dahle Jostein , de Vries Elisabeth G. E. , Pool Martin 
Published: April 2022

Abstract[177Lu]Lu-DOTA-NNV003, a radioimmunoconjugate targeting CD37, is developed as novel radioimmunotherapy (RIT) treatment for patients with B cell non-Hodgkin’s lymphoma (NHL). Since patients are at risk for developing hematological toxicities due to CD37 expression on normal B cells, we aimed to develop 89Zr-labeled NNV003 for positron emission tomography (PET) imaging as a surrogate tool to predict [177Lu]Lu-DOTA-NNV003 RIT whole-body distribution and tumor uptake. NNV003 antibody was first radiolabeled with 89Zr. [89Zr]Zr-N-sucDf-NNV003 tumor uptake was evaluated by PET imaging of mice bearing human CD37-expressing REC1 B cell NHL or RAMOS Burkitt’s lymphoma xenograft tumors followed by ex vivo analysis. Finally, CD37-targeting of [89Zr]Zr-N-sucDf-NNV003 and [177Lu]Lu-DOTA-NNV003 RIT were compared. [89Zr]Zr-N-sucDf-NNV003 accumulated in REC1 tumors over time, which was not observed for non-specific, 111In-labeled IgG control molecule. In RAMOS tumor-bearing mice, [89Zr]Zr-N-sucDf-NNV003 tumor uptake was higher than [111In]In-DTPA-IgG at all tested tracer protein doses (10 µg, 25 µg and 100 µg; P < 0.01), further confirming [89Zr]Zr-N-sucDf-NNV003 tumor uptake is CD37-mediated. [89Zr]Zr-N-sucDf-NNV003 and [177Lu]Lu-DOTA-NNV003 RIT showed similar ex vivo biodistribution and tumor uptake in the RAMOS tumor model. In conclusion, [89Zr]Zr-N-sucDf-NNV003 PET imaging can serve to accurately predict CD37-targeting of [177Lu]Lu-DOTA-NNV003. To enable clinical implementation, we established a good manufacturing practice (GMP)-compliant production process for [89Zr]Zr-N-sucDf-NNV003.
Static and fatigue tensile properties of carbon/glass hybrid fiber-reinforced epoxy composites
Authors: Naito Kimiyoshi 
Published: April 2022

AbstractThe static and fatigue tensile properties of high-strength polyacrylonitrile (PAN)-based carbon (IMS60) and electronic (E)-class glass (E-glass) hybrid fiber-reinforced epoxy matrix composites (HFRPs) were investigated. The fiber orientations of the HFRP specimens were set to unidirectional with [(0(IMS60))/(0(E-glass))]S (subscript S means symmetry and [(0(IMS60))/(0(E-glass))/(0(E-glass))/(0(IMS60))]), [(0(E-glass))/(0(IMS60))]S, [(0(E-glass))/(0(IMS60))2]S, [(0(E-glass))/(0(IMS60))3]S, [(0(E-glass))/(0(IMS60))5]S, [(0(E-glass))2/(0(IMS60))]S, [(0(E-glass))3/(0(IMS60))]S, and [(0(E-glass))5/(0(IMS60))]S. Under static loading for the [(0(IMS60))/(0(E-glass))]S, [(0(E-glass))/(0(IMS60))]S, [(0(E-glass))/(0(IMS60))2]S, [(0(E-glass))/(0(IMS60))3]S, and [(0(E-glass))/(0(IMS60))5]S HFRP specimens, the stress applied to the specimen was almost linearly proportional to the strain until failure. However, the tensile stress–strain curves of the [(0(E-glass))2/(0(IMS60))]S, [(0(E-glass))3/(0(IMS60))]S, and [(0(E-glass))5/(0(IMS60))]S HFRP specimens had a complicated shape (jagged trace). The Weibull statistical distributions of the tensile strength values were also examined. The Weibull moduli for the [(0(E-glass))/(0(IMS60))]S, [(0(E-glass))/(0(IMS60))2]S, [(0(E-glass))/(0(IMS60))3]S, [(0(E-glass))/(0(IMS60))5]S, [(0(E-glass))2/(0(IMS60))]S, [(0(E-glass))3/(0(IMS60))]S, and [(0(E-glass))5/(0(IMS60))]S HFRP specimens were higher than those for the mono carbon fiber-reinforced epoxy (CFRP) and glass fiber-reinforced epoxy (GFRP) specimens. Under fatigue loading, the fatigue properties of the HFRP specimens showed CFRP-dominant behaviour at high stress levels and GFRP-dominant behaviour at low stress levels. The fatigue properties of the HFRP specimens increased with increasing volume fraction of CFRP in the following order: ([(0(E-glass))/(0(IMS60))5]S > [(0(E-glass))/(0(IMS60))3]S > [(0(E-glass))/(0(IMS60))2]S > [(0(IMS60))/(0(E-glass))]S > [(0(E-glass))/(0(IMS60))]S > [(0(E-glass))2/(0(IMS60))]S > [(0(E-glass))3/(0(IMS60))]S > [(0(E-glass))5/(0(IMS60))]S).
Complementary feeding pattern and its determinants among mothers in selected primary health centers in the urban metropolis of Ekiti State, Nigeria
Authors: Esan Deborah Tolulope , Adegbilero-Iwari Oluwaseun Eniola , Hussaini Aishat , Adetunji Aderonke Julienne 
Published: April 2022

AbstractThe incidence of malnutrition in the first two years of life has been directly linked with inappropriate complementary feeding practices along with high infectious disease levels. This study was therefore aimed to assess the complementary feeding pattern among mothers of children aged zero to two years in selected health centres in Ado Ekiti, the capital of Ekiti State, Nigeria. The study was cross-sectional in design. One hundred and thirty-five mothers were selected from two health centres within Ado-Ekiti for this study. A semi-structured interviewer-administered questionnaire was used to collect information from the mothers. The questionnaire included questions that assessed the mothers’ socio-demographic characteristics and complementary feeding pattern. Most (62.5%) infants were introduced to complementary foods at 3–5 months old and water (43.3%) at 3 months of age. The main food item given to the infants on commencement of complementary feeding was formula food (45.9%) followed by fermented cereal gruel (37%). The timing of introduction for different food items revealed that in contrast to the use of fermented cereal gruel (23.8%), fewer children were introduced to iron-rich foods (15.1%) and fruits (11%) at 6 months to a year old. Mother’s knowledge of ideal age for the introduction of complementary feeding ($${\chi }^{2}=$$

χ

2

=

20.547; p < 0.001) associated significantly with the age of introduction of complementary feeding. More than three-fifth (62.5%) of the respondents had commenced complementary feeding to their infants between 3 and 5 months while an excess of two-fifth (43.3%) of the respondents started giving their children water to drink at 3 months of age. Nurses and nutritionists in primary health care centers should take the lead role in educating mothers about the need for exclusive breastfeeding for the first 6 months of life and appropriate complementary feeding for ages 6–24 months.
Development of a novel green coating process with laser
Authors: Zhong Chongliang , Backes Gerhard , Johann Lukas Martin , Kittel Jochen , Schopphoven Thomas , Küppers Wolfgang 
Published: April 2022

AbstractCorrosion causes costs of about 3–4% of each country’s gross domestic product, and due to the climate change, the corrosion rates on infrastructure are likely to increase furtherly in the future1,2. For corrosion protection, hard chrome plating (HCP) is commercially used since the early 20th3. Yet the biggest drawback concerns environmental protection, since toxic and carcinogenic hexavalent chromium Cr6+ is used. As an alternative, thermal spray (TS) is increasingly used since the last 20 years. Nevertheless, the coatings are technologically constrained in regard to high porosity, low material efficiency and poor bonding to the base material. Therefore, the demand for an environmental friendly and economical process that produces high-quality coatings is increasingly coming into the research focus. With laser, dense, metallurgically bonded and therefore well-adhering coatings with high material efficiency of > 90% can be produced from a large number of metallic alloys without the need to use environmentally harmful chemicals or noise emissions. However, the typical area coating rate of < 0.4 m2/h is significantly lower than that of TS of about 10 m2/h4,5, and is too small for coating large-scale components. In this regard, a novel coating process with laser was developed in this work. By decoupling the melding of powder from the coating speed, the coating speed of < 2 m/min in conventional laser coating can be increased to > 500 m/min. Defect-free layers that metallurgically bond to the base material with a thickness of 50–250 µm and a material efficiency of > 90% can be achieved. According to the results, an area coating rate up to 20 m2/h is achievable. The pioneer work of applications in offshore and automobile sectors show, this process is already providing beneficial for the industry.
HADES RV Programme with HARPS-N at TNG
Authors: Pinamonti M. , Sozzetti A. , Maldonado J. , Affer L. , Micela G. , Bonomo A. S. , Lanza A. F. , Perger M. , Ribas I. , González Hernández J. I. , Bignamini A. , Claudi R. , Covino E. , Damasso M. , Desidera S. , Giacobbe P. , González-Álvarez E. , Herrero E. , Leto G. , Maggio A. , Molinari E. , Morales J. C. , Pagano I. , Petralia A. , Piotto G. , Poretti E. , Rebolo R. , Scandariato G. , Suárez Mascareño A. , Toledo-Padrón B. , Zanmar Sánchez R. 
Published: April 2022

Aims. We present the complete Bayesian statistical analysis of the HArps-n red Dwarf Exoplanet Survey (HADES), which monitored the radial velocities of a large sample of M dwarfs with HARPS-N at TNG over the last 6 yr.
Methods. The targets were selected in a narrow range of spectral types from M0 to M3, 0.3 M⊙ < M★ < 0.71 M⊙, in order to study the planetary population around a well-defined class of host stars. We take advantage of Bayesian statistics to derive an accurate estimate of the detectability function of the survey. Our analysis also includes the application of a Gaussian Process approach to take into account stellar-activity-induced radial velocity variations and improve the detection limits around the most-observed and most-active targets. The Markov chain Monte Carlo and Gaussian process technique we apply in this analysis has proven very effective in the study of M-dwarf planetary systems, helping the detection of most of the HADES planets.
Results. From the detectability function we can calculate the occurrence rate of small-mass planets around early-M dwarfs, either taking into account only the 11 already published HADES planets or adding the five new planetary candidates discovered in this analysis, and compare them with the previous estimates of planet occurrence around M-dwarf or solar-type stars: considering only the confirmed planets, we find the highest frequency for low-mass planets (1 M⊕ < mp sin i < 10 M⊕) with periods 10 d < P < 100 d, ${f_{{\rm{occ}}}} = 0.85_{ - 0.21}^{ + 0.46}$, while for short-period planets (1 d < P < 10 d) we find a frequency of ${f_{{\rm{occ}}}} = 0.10_{ - 0.03}^{ + 0.10}$, significantly lower than for later-M dwarfs; if instead we also take into account the new candidates, we observe the same general behaviours, but with consistently higher frequencies of low-mass planets. We also present new estimates of the occurrence rates of long-period giant planets and temperate planets inside the habitable zone of early-M dwarfs: in particular we find that the frequency of habitable planets could be as low as η⊕ < 0.23. These results, and their comparison with other surveys focused on different stellar types, confirm the central role that stellar mass plays in the formation and evolution of planetary systems.
Januskinase-Inhibitoren: Next-Generation-Therapie der Uveitis
Authors: El-Shabrawi Yosuf , Rath Thomas , Heiligenhaus Arnd 
Published: April 2022

ZusammenfassungViele PatientInnen mit visusgefährdender nicht infektiöser Uveitis bedürfen, um eine Remission ihrer Uveitis zu erreichen, einer Behandlung mit DMARDs. Obwohl herkömmliche DMARD-Therapien
in einem großen Teil dieser PatientInnen eine hochpotente Therapie darstellen, ist in einzelnen Fällen aufgrund eines unzureichenden Ansprechens oder unerwünschter Wirkungen ein
Therapiewechsel erforderlich. Januskinase-Inhibitoren (JAKI) sind in der Rheumatologie, Gastroenterologie und Dermatologie bereits für mehrere autoimmune Erkrankungen zugelassen. Nun steht
ein Zulassungsprozess für ausgewählte Uveitisentitäten an. Wirkmechanismus: JAKI üben ihre Wirkung über die Hemmung der Phosphorylierung von Transmembranproteinen, den Januskinasen aus. Dies
führt zu einer fehlenden Aktivierung von Transkriptionsfaktoren und damit zur verminderten Zytokinexpression und Entzündungshemmung. JAKI stellen in der Rheumatologie, Gastroenterologie und
Dermatologie einen äußerst effektiven neuen therapeutischen Ansatz dar. Sie sind zur Behandlung bei rheumatoider Arthritis, Psoriasis-Arthritis, ankylosierender Spondylitis, Colitis ulcerosa
und dem atopischen Ekzem bereits zugelassen. In bisherigen Vergleichsstudien zu etablierten Biologika konnte teilweise ein besseres therapeutisches Ansprechen beschrieben werden. Aus
publizierten Fallberichten wurde auch bei Uveitispatienten, die auf klassische und biologische DMARDs unzureichend ansprachen, eine Kortisoneinsparung und Reizfreiheit erzielt.
Zulassungsstudien bei JIA-assoziierter und ANA-positiver anteriorer Uveitis sind im Prozess. Zusammenfassend stellen JAKI eine innovative Therapieoption bei Patienten mit nicht infektiöser
Uveitis dar, bei denen Kontraindikationen gegen die Verwendung oder ein unzureichender Effekt von DMARDs bestehen.
Corneal Oedema: Aetiology, Diagnostic Testing, and Treatment
Authors: Zander Daniel Bernhard , Jiang Jana , Reinhard Thomas , Wacker Katrin 
Published: April 2022

AbstractCorneal oedema results from an underlying pathology, which can be diverse in origin, and may be mechanical, dystrophic, or inflammatory, and affect any layer of the cornea. Diagnostic tools
such as Scheimpflug imaging and anterior segment optical coherence tomography have standardised quantification of corneal oedema and have become important aids in clinical practice. Timely
diagnosis and treatment are key to preventing irreversible damage to the corneal ultrastructure, such as anterior corneal fibrosis or endothelial cell damage. The oedema usually resolves
quickly when the underlying cause has been addressed. Symptomatic treatment using hyperosmolar agents has failed to show any benefits in oedema resolution or improvement in visual acuity
compared to placebo. In contrast, rho-associated protein kinase (ROCK) inhibitors offer a promising option for medical treatment in cases of endothelial dysfunction, but their safety and
efficacy must be further validated in large scale clinical trials. Until then, endothelial or penetrating keratoplasties remain the mainstay treatment where structural changes to the cornea
have occurred.