bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resistance exercise training-induced skeletal muscle strength provides protective effects on high-fat-diet-induced metabolic stress in mice
Authors: Kim Hye Jin , Kim Youn Ju , Kim Il Yong , Seong Je Kyung 
Published: December 2022

Abstract
Background
Resistance exercise training is known to improve metabolic disorders, such as obesity and type2 diabetes. In this study, we investigated whether the beneficial effects of resistance exercise training persisted even after the discontinuation of training with high-fat diet (HFD)-induced metabolic stress. We further evaluated whether the improvement in skeletal muscle strength and endurance by training were correlated with improved metabolism. Eight-week-old male C57BL/6N mice were divided into groups that remained sedentary or had access to daily resistance exercise via ladder climbing for 8 weeks. Trained and untrained mice were fed an HFD for 1 week after the exercise training intervention (n = 5–8 per group).

Results
Resistance exercise-trained mice had a lean phenotype and counteracted diet-induced obesity and glucose tolerance, even after exercise cessation. Grip strength was significantly inversely correlated with the body weight, fat mass, and glucose tolerance. However, hanging time was significantly inversely correlated with body weight only.

Conclusions
These results have strong implications for the preventive effect of resistance exercise-induced metabolic improvement by enhancing skeletal muscle strength rather than endurance.
Entry of the antipsychotic drug, olanzapine, into the developing rat brain in mono- and combination therapies
Authors: Huang Yifan , Qiu Fiona , Habgood Mark , Nie Shuai , Dziegielewska Katarzyna , Saunders Norman 
Published: December 2022

Background: Olanzapine is used to treat schizophrenia and bipolar disorder in women of childbearing age. Continuation of psychotropic medications throughout pregnancy and lactation is often required as cessation could be dangerous for both mother and child. However, there is a lack of information on the transfer of these drugs into the developing brain. Methods: Sprague Dawley rats at three developmental ages: embryonic day E19, postnatal day P4 and non-pregnant adult females were administered unlabelled or radiolabelled (3H) olanzapine (0.15 mg/kg) either as monotherapy or in combination with each of seven other common medications. Similar injections were administered to pregnant E19 females to investigate placental transfer. Olanzapine in plasma, cerebrospinal fluid (CSF) and brain was measured by liquid scintillation counting after a single dose (acute) or following 5 days of treatment (prolonged). Results: Olanzapine entry into brain and CSF was not age-dependent. Prolonged olanzapine treatment reduced placental transfer from 53% to 46% (p<0.05). Co-administration of digoxin or lamotrigine with olanzapine increased its entry into the fetal brain, whereas paracetamol decreased its entry into the CSF. Placental transfer of olanzapine was increased by co-treatment with cimetidine and digoxin, whereas co-treatment with lamotrigine, paracetamol or valproate led to a substantial decrease. Repeated co-treatment of digoxin and olanzapine increased olanzapine transfer into the brain and CSF, but not across the placenta. Overall entry of olanzapine from maternally administered drugs into the fetal brain was higher after combination therapy with cimetidine and digoxin. Conclusions: Co-administration of olanzapine with some commonly used drugs affected its entry into the fetus and its developing brain to a greater extent than in adults. It appears that protection of the fetal brain for these drugs primarily comes from the placenta rather than from the fetal brain barriers. Results suggest that drug combinations should be used with caution particularly during pregnancy.
Alegorie dzielenia się obrazami (na podstawie praktyki edukacyjnej)
Authors: Dąbrowska Danuta 
Published: December 2022

Artykuł jest podsumowaniem dorobku Pracowni Projektowania Wydawnictw Multimedialnych i Książki Artystycznej prowadzonej w latach 2013–2021 w Akademii Sztuki w Szczecinie. Tytuł Alegorie dzielenia się historiami jest rozwinięciem tematu na podstawie praktyki edukacyjnej związanej z autorskim programem Pracowni.
Książka jako obiekt sztuki stanowi chętnie wybierane medium, zwłaszcza przez najmłodsze pokolenia artystów. Jest uniwersalnym i wielowymiarowym językiem wypowiedzi. Doskonale wpisuje się w kontekst sztuki współczesnej z jej historiozoficznym zapleczem. Wszelkie formy i przejawy zjawiska, jakimi są artbooki, doczekały się wielu pogłębionych analiz, jednak z uwagi na duży progres tego nurtu cenny okazuje się każdy rodzaj refleksji i próby definiowania. Odważne i niejednokrotnie wnikliwe studenckie eksperymenty projektowe są asumptem do tej prezentacji.
Privacy Rights and Data Security: GDPR and Personal Data Markets
Authors: Ke T. Tony , Sudhir K. 
Published: December 2022

General Data Protection Regulation (GDPR)—the European Union’s data protection regulation—has two key principles. It recognizes that individuals own and control their personal (but not contractual) data in perpetuity, leading to three critical privacy rights, namely, the rights to (i) explicit consent (data opt-in), (ii) to be forgotten (data erasure), and (iii) portability (data transfer). It also includes data security mandates against privacy breaches through unauthorized access. We study GDPR’s equilibrium impact by including these features in a dynamic two-period model of forward-looking firms and consumers. Firms collect consumer data for personalization and price discrimination. Consumers trade off gains from personalization relative to potential losses from privacy breaches and price discrimination in their purchase, data opt-in, erasure, and transfer decisions. Though data security mandates impose fines on firms for privacy breaches, firms can benefit from higher opt-in given lower breach risk. Surprisingly, data security mandates can hurt consumers. The effect of privacy rights is nuanced. Since the right to opt in separates goods exchange from the provision of personal data, it prevents market failure under high breach risk. But it also reduces consumer opt-in and personal data availability. Erasure and portability rights reduce consumers’ hold-up concerns by disciplining firms to provide ongoing value by limiting price discrimination and not slacking off on data security; but they also reduce the incentive to offer lower initial prices that encourages opt-in. Overall, privacy rights always benefit consumers in competitive markets, but they can surprisingly hurt consumers under monopoly, as monopolists have less incentives to subsidize consumer opt-in. They raise (reduce) firm profit and social welfare when breach risk is high (low). Finally, privacy rights increase firm profit most at moderate levels of data transferability. This paper was accepted by Dmitri Kuksov, marketing. Funding: T. T. Ke acknowledges financial support from the General Research Fund of the Hong Kong Research Grants Council [Grant 14500421]. Supplemental Material: The e-companion is available at https://doi.org/10.1287/mnsc.2022.4614 .
National mapping of municipality-based rehabilitation services for patients recovering from COVID-19 in Denmark: a cross-sectional study
Authors: Bloomquist Kira , Tang Lars H , Kjelsbak Sissel , Hansen Linea L , Christensen Jan 
Published: December 2022

Background/aims A lack of knowledge exists as to how municipalities are meeting the rehabilitation needs of patients recovering from COVID-19. This poses a potential barrier when referring patients for rehabilitation. The aim of this study was to map and describe municipality-based rehabilitation services for patients recovering from COVID-19 in Denmark. Methods This was a cross-sectional, nation-wide survey. Key staff members from all 98 municipalities in Denmark were invited to participate. Participants had insight into the organisation and professional content of municipal rehabilitation. Structured telephone interviews were conducted by three interviewers between October and November 2020. The interview guide consisted of items that asked about the availability, content and organisation of municipality-based rehabilitation services. Results A total of 91 municipalities (93% response rate) participated in the study. Rehabilitation could be provided within pre-existing services in 98% of municipalities and 93% systematically assessed individual rehabilitation needs using a variety of measurement methods. All municipalities reported that they had services in place to provide functional rehabilitation (eg gait training) and over 90% provided physical, cognitive and lifestyle-related rehabilitation. In contrast, 70% could provide COVID-19 education and 64% psychological therapy. Overall, 32% of municipalities had not received referrals for COVID-19 rehabilitation. Of the 62 municipalities that had COVID-19 rehabilitation experience, 73% rated the degree to which they could deliver coherent and coordinated rehabilitation for patients with complex rehabilitation needs as high or very high. Conclusions Overall, Danish municipalities reported that pre-existing services are in place to provide relevant, individualised rehabilitation for patients recovering from COVID-19. Nonetheless, future efforts should ensure that patient education is established, in step with health care providers accumulating knowledge, as well as integrated referral pathways between sectors, to deliver rehabilitation to patients with complex needs. Further, implementation of a national data collection strategy would strengthen and inform future development of relevant services both nationally and internationally.
Knowledge and attitude towards strabismus among adult residents in Woreta town, North West Ethiopia: A community-based study
Authors: Alemayehu Henok Biruk , Tsegaye Kalkidan Berhane , Ali Fozia Seid , Adimassu Nebiyat Feleke , Mersha Getasew Alemu 
Published: December 2022

Background
Strabismus is a visual disorder where the eyes are misaligned and point in different directions. Untreated strabismus can lead to amblyopia, loss of binocular vision, and social stigma due to its appearance. Since it is assumed that knowledge is pertinent for early screening and prevention of strabismus, the main objective of this study was to assess knowledge and attitudes toward strabismus in Woreta town, Northwest Ethiopia. Providing data in this area is important for planning health policies.

Methods
A community-based cross-sectional study was done in Woreta town from April–May 2020 with a sample size of 424. A systematic random sampling technique was employed to achieve the required sample size. A pre-tested self-administered questionnaire was used to collect the data. Data were entered using epi-data version 3.1, then processed and analyzed via SPSS version 20. Descriptive and analytical statistics were employed to summarize the data. A p-value of less than 0.05 was used to declare statistical significance.

Result
A total of 401 individuals aged over 18 years participated, with a response rate of 94.5%. Of those who responded, 56.6% were males. Of all the participants, 36.9% were illiterate. The proportion of people with poor knowledge of strabismus was 45.1%. It was shown that 53.9% of the respondents had a favorable attitude. Older age, higher educational level, having a history of eye examination, and a having a family history of strabismus were significantly associated with good knowledge of strabismus. A higher educational level, older age, and hearing about strabismus were significantly associated with a favorable attitude toward strabismus.

Conclusion and recommendation
The proportion of good knowledge and favorable attitude towards strabismus were lower than previously reported in Gondar City, Northwest Ethiopia. There is a need to provide health education and promotion campaigns on strabismus to the community: what strabismus is, its’ possible treatments and the need to bring children to the eye care center for early diagnosis and treatment.
Characterization of a proteomic profile associated with organ dysfunction and mortality of sepsis and septic shock
Authors: Ruiz-Sanmartín Adolfo , Ribas Vicent , Suñol David , Chiscano-Camón Luis , Palmada Clara , Bajaña Iván , Larrosa Nieves , González Juan José , Canela Núria , Ferrer Ricard , Ruiz-Rodríguez Juan Carlos 
Published: December 2022

IntroductionThe search for new biomarkers that allow an early diagnosis in sepsis and predict its evolution has become a necessity in medicine. The objective of this study is to identify, through omics techniques, potential protein biomarkers that are expressed in patients with sepsis and their relationship with organ dysfunction and mortality.MethodsProspective, observational and single-center study that included adult patients (≥ 18 years) who were admitted to a tertiary hospital and who met the criteria for sepsis. A mass spectrometry-based approach was used to analyze the plasma proteins in the enrolled subjects. Subsequently, using recursive feature elimination classification and cross-validation with a vector classifier, an association of these proteins with mortality and organ dysfunction was established. The protein-protein interaction network was analyzed with String software.Results141 patients were enrolled in this study. Mass spectrometry identified 177 proteins. Of all of them, and by recursive feature elimination, nine proteins (GPX3, APOB, ORM1, SERPINF1, LYZ, C8A, CD14, APOC3 and C1QC) were associated with organ dysfunction (SOFA > 6) with an accuracy of 0.82 ± 0.06, precision of 0.85 ± 0.093, sensitivity 0.81 ± 0.10, specificity 0.84 ± 0.10 and AUC 0.82 ± 0.06. Twenty-two proteins (CLU, LUM, APOL1, SAA1, CLEBC3B, C8A, ITIH4, KNG1, AGT, C7, SAA2, APOH, HRG, AFM, APOE, APOC1, C1S, SERPINC1, IGFALS, KLKB1, CFB and BTD) were associated with mortality with an accuracy of 0.86 ± 0.05, a precision of 0.91 ± 0.05, a sensitivity of 0.91 ± 0.05, a specificity of 0.72 ± 0.17, and an area under the curve (AUC) of 0.81 ± 0.08 with a confidence interval of 95%.ConclusionIn sepsis there are proteomic patterns associated with organ dysfunction and mortality.
Сarbohydrate metabolism disorders and their outcomes in the long-term period in hospitalized patients with COVID-19
Authors: Salukhov V. V. , Minakov A. A. , Sharypova T. G. , Kononova A. A. , Surkhaeva V. A. 
Published: December 2022

BACKGROUND: Diabetes mellitus (DM) is a predisposing factor for the development of many infectious complications. Numerous studies have demonstrated the association of hyperglycemia in patients having DM with a high risk of a more unfavorable course of COVID-19. However, hyperglycemia is often detected in patients with a COVID-19 not having anamnesis of DM. The following remains unclear: the etiological factors causing such disorders of carbohydrate metabolism, the persistence of these disorders and the characteristics of the course, as well as their comparative effect on the outcomes of COVID-19 and the further prognosis of patients.AIM: To study the prevalence and nature of carbohydrate metabolism disorders in patients with moderate to severe course of COVID-19, as well as 6 months after it.MATERIALS AND METHODS: Hospitalized patients with a confirmed diagnosis of COVID-19 of moderate and severe course of the disease were examined. There were no medical interventions outside recommendations of patient management. The observation was carried out during two time periods: inpatient treatment of a COVID-19 and 6 months after discharge. The following were evaluated: anamnesis data, the level of fasting plasma glucose; HbA1c, the results of computed tomography of the lungs, the drug therapy taken in all patients. Descriptive statistics methods were used to evaluate the parameters.RESULTS: The study included 280 patients with a median age of 61.5±14,2 years. During the disease, a violation of carbohydrate metabolism was detected in 188 people (67%), the remaining patients (33%) made up the normoglycemia group. Patients with hyperglycemia were stratified in a following way: a group with an established diagnosis of DM before COVID -19 included — 56 people (20%), a group with steroid-induced hyperglycemia (SIH) — 95 people (34%), a group of stress- induced hyperglycaemia — 20 people (7%), with undiagnosed diabetes — 17 people (6%). In the postcovid period (after 6 months), the normal level of glycemia in the same sample group was observed in 199 people (71.4%); 8 people (3%) were diagnosed with new cases of DM. The mortality rate was 10 people (3.6%) in the group of SIH (8 people) and undiagnosed DM (2 people).CONCLUSION: The use of glucocorticoids in hospitalized patients with COVID-19 leads to high incidence of SIH, which has reversible character. About 6% among hospitalized patients with a COVID-19 had undiagnosed DM and were not receiving antihyperglycemic therapy. The highest mortality was noted in the group of SIH, which allows us to conclude that SIH worsens the prognosis of patients to the greatest extent. Patients with newly diagnosed hyperglycemia, regardless of the level of hyperglycemia, are characterized by a more unfavorable course.
Analysis of risk factors for COVID-19-related fatal outcome in 337991 patients with type 1 and type 2 diabetes mellitus in 2020–2022 years: Russian nationwide retrospective study
Authors: Mokrysheva N. G. , Shestakova M. V. , Vikulova O. K. , Elfimova A. R. , Isakov M. A. , Gins N. A. , Deviatkin A. A. , Dedov I. I. 
Published: December 2022

BACKGROUND: The coronavirus pandemic has had an extremely negative impact on the patients with diabetes mellitus (DM both in terms of a more severe course of COVID -19 and an increased risk of death.AIM: Analysis of risk factors for death due to COVID -19 in patients with DM type 1 and type 2 (DM1 and DM2).MATERIALS AND METHODS: Retrospective analysis of the database of the national diabetes register (NDR), which included DM patients with COVID-19 and reported virus infection outcome (recovery/or death) in 15 712 DM1 and 322 279 DM2 patients during a 2-year follow-up period (01/02/2020 to 03/04/2022) (discharge date)).RESULTS: Case fatality rate in patients with DM, who underwent COVID -19 was 17.1% (DM1–8.8%; DM2–17.5%). As a result of multivariate regression analysis of seven significant factors in DM1 and thirteen in DM2 (evaluated by univariate anlisys), a number of the most important predictors of risk for fatal outcome were identified: in DM1 these were age ≥65 years (OR =4.01, 95% CI: 1.42–11.36), presence of arterial hypertension (AH) (OR =2.72, 95% CI: 1.03 -7.16) and diabetic foot syndrome (DFS) (OR = 7.22, 95% CI: 1.98–26.29); for T2DM: age ≥ 65 years (OR =2.53, 95% CI: 1.96–3.27), male (OR =1.51, 95% CI: 1.23–1.84), duration DM ≥10 years (OR =2.01, 95% CI: 1.61–2.51), BMI ≥ 30 kg/m2 (OR =1.26, 95% CI: 1.02–1.55), ASCVD/CKD (OR =1.49, 95% CI: 1.01–2.04), history of diabetic coma (OR =12.97, 95% CI: 1.89–88.99) and presence of disability ( OR =1.40, 95% CI: 1.14–1.73). In T2DM, the type of antidiabetic therapy (ADT) prior to COVID -19 (last visit before the development of infection) had a significant impact: Insulin therapy (OR = 1.64, 95% CI: 1.30–2.07), sulfonylureas (SU) (OR =1.51, 95% CI: 1.23–1.84)); dipeptidyl peptidase-4 inhibitor (iDPP-4) therapy (OR =0.57, 95% CI: 0.39–0.83) and sodium-glucose cotransporter-2 inhibitor (iSGLT2) therapy (OR =0.64, 95% CI: 0.46–0.88). Vaccination was the most important protective factor in both types of DM: DM1 OR =0.19, 95% CI: 0.06–0.59; SD2 OR =0.20, 95% CI: 0.16–0.26.CONCLUSION: The common risk factor for fatal outcome in both DM1 and DM2 was age ≥65 years; in DM1 — history of hypertension and DFS, in DM2 — male sex, diabetes duration ≥10 years, BMI ≥30 kg/m2, history of ASCVD/CKD and diabetic coma, disability. In T2DM, significant differences in risk were observed depending on the type of ADT: insulin and SU therapy were factors that increased the risk of death, whereas therapy with iDPP-4 and iSGLT2 reduced the risk of death. Vaccination reduced the risk of death in DM1 and DM2 by 5.2 and 5-fold, respectively.
BENEFÍCIOS SOCIAIS E AMBIENTAIS DA USINA DE RECICLAGEM E COMPOSTAGEM NA CIDADE DE PRATA-MG
Authors: Lopes Anaísa Filmiano Andrade , Pompeu Diogo Sá da Silva 
Published: December 2022

As questões ambientais vêm assumindo posição de relevância frente Ã geopolítica mundial. Um dos temas mais debatidos relaciona-se a disposição final dos resíduos sólidos, problema crônico que afeta diretamente a sociedade contemporânea. Para minimização dos impactos ambientais, advindos da destinação, foram criados mecanismos de gestão e gerenciamento dos resíduos, um desses mecanismos é a criação das Usinas de Reciclagem e Compostagem (URC). Portanto, a presente pesquisa objetiva realizar um estudo de caso e analisar o funcionamento da Usina de Reciclagem e Compostagem na cidade de Prata-MG, juntamente com os benefícios sociais e ambientais advindos a partir de sua implantação. O método utilizado foi de natureza qualitativa e descritiva, os resultados alcançados são promissores, tanto em termos sociais quanto ambientais. A URC da cidade proporciona trabalho e renda para os catadores de materiais recicláveis e contribui para a qualidade ambiental, aumentando a vida útil dos materiais por meio da reciclagem e da compostagem.
DISTRIBUIÇÃO ESPAÇO-TEMPORAL DAS RECLAMAÇÕES SOBRE POMBOS (Columba livia domestica) EFETUADAS AO CENTRO DE CONTROLE DE ZOONOSES DE NITERÓI, RJ (2009-2013)
Authors: Moutinho Flavio Fernando Batista , Serra Cathia Maria Barrientos , Valente Luiza Carneiro Mareti , Borges Fabio Villas Boas , Faria Neto Francisco de 
Published: December 2022

Os pombos são fonte de incômodo para muitas pessoas e geram reclamações da população em diversos países do mundo em consequência da superpopulação e de suas características sinantrópicas. Foi efetuado um levantamento documental dos registros de reclamações da comunidade sobre o assunto feitas ao Centro de Controle de Zoonoses de Niterói, RJ, no período 2009-2013. Os dados foram espacializados em função das regiões administrativas e bairros. A análise foi realizada por meio de técnicas de estatística descritiva. Os resultados encontrados foram correlacionados em relação ao tamanho da população, à temperatura mensal média e Ã renda por domicílio. Houve média de 50,2 reclamações por ano. Foram encontradas correlação fortemente positiva com o tamanho da população humana e correlação fraca com a renda por domicílio. As reclamações apresentaram um caráter sazonal, com predomínio no outono e no inverno, e correlação negativa com a temperatura média mensal. A distribuição das reclamações vem se expandindo para novas áreas, havendo, ainda, bairros em que o problema persiste e aqueles em que nunca houve reclamações. Com relação à sazonalidade encontrada, maiores estudos deverão ser realizados para se confirmar a existência de uma relação com aspectos biológicos ou comportamentais dos pombos em Niterói.