bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Specific Cervical Cancer Subtypes and Prognostic Gene Sets in Tumor and Nontumor Tissues Based on GSVA Analysis
Authors: Zhong Zihang , Wang Yuanyuan , Yin Jian , Ni Senmiao , Liu Wen , Geng Rui , Liu Jinhui , Bai Jianling , Yu Hao 
Published: October 2022

Background. Cervical cancer is the fourth common cancer among women. Its prognosis needs our more attention. Our purpose was to identity new prognostic gene sets to help other researchers develop more effective treatment for cervical cancer patients and improve the prognosis of patients. Methods. We used gene set variation analysis (GSVA) to calculate the enrichment scores of gene sets and identified three subtypes of cervical cancer through the Cox regression model, k-means clustering algorithm, and nonnegative matrix factorization method (NMF). Chi-square test was utilized to test whether a certain clinical characteristic is different among divided subtypes. We further screened the prognostic gene sets using differential analysis, univariate Cox regression analysis, and least absolute shrinkage and selection operator (LASSO) regression. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were used to analyze which pathways and function the genes from screened gene sets enriched. Search Tool for the Retrieval of Interacting Genes (STRING) was used to draw the protein-protein interaction network, and Cytoscape was used to visualize the hub genes of protein-protein interaction network. Results. We identified three novel subtypes of cervical cancer in The Cancer Genome Atlas (TCGA) samples and validated in Gene Expression Omnibus (GEO) samples. There were significant variations between the three subtypes in histological type, T stage, M stage, and N stage. T_GSE36888_UNTREATED_VS_IL2_TREATED_STAT5_AB_KNOCKIN_TCELL_2H_UP and N_HALLMARK_ANGIOGENESIS were screened prognostic gene sets. The prognostic model was as follows:

riskScore
=
T
_
GSE
36888
_
UNTREATED
_
VS
_
IL
2
_
TREATED
_
STAT
5
_
AB
_
KNOCKIN
_
TCELL
_
2
H
_
U

P

∗

2.617
+
N
_
HALLMARK
_
ANGIOGENESI

S

∗

4.860

. Survival analysis presented that in these two gene sets, high enrichment scores were all significantly related to worse overall survival. The hub genes from T gene set included CXCL1, CXCL2, CXCL8, ALDOA, TALDO1, LDHA, CCL4, FCAR, FCER1G, SAMSN1, LILRB1, SH3PXD2B, PPM1N, PKM, and FKBP4. As for N gene sets, the hub genes included ITGAV, PTK2, SPP1, THBD, and APOH. Conclusions. Three novel subtypes and two prognostic gene sets were identified. 15 hub genes for T gene set and 5 hub genes for N gene set were discovered. Based on these findings, we can develop more and more effective treatments for cervical cancer patients. Based on the gene enriched pathways, we can development specific drugs targeting the pathways.
NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy
Authors: Lin Tongtong , Hu Liang , Hu Fan , Li Kun , Wang Chao-Yu , Zong Li-Juan , Zhao Ya-Qian , Zhang Xiaotao , Li Yan , Yang Yang , Wang Yu , Jiang Chun-Yi , Wu Xuefeng , Liu Wen-Tao 
Published: October 2022

Abstract

Oxaliplatin is an antineoplastic agent frequently used in the treatment of gastrointestinal tumors. However, it causes dose-limiting sensorimotor neuropathy, referred to as oxaliplatin-induced peripheral neuropathy (OIPN), for which there is no effective treatment. Here, we report that the elevation of neutrophil extracellular traps (NET) is a pathologic change common to both cancer patients treated with oxaliplatin and a murine model of OIPN. Mechanistically, we found that NETs trigger NLR family pyrin domain containing 3 (NLRP3) inflammasome activation and the subsequent release of IL18 by macrophages, resulting in mechanical hyperalgesia. In NLRP3-deficient mice, the mechanical hyperalgesia characteristic of OIPN in our model was reduced. In addition, in the murine model, treatment with the IL18 decoy receptor IL18BP prevented the development of OIPN. We further showed that eicosapentaenoic acid (EPA) reduced NET formation by suppressing the LPS–TLR4–JNK pathway and thereby abolished NLRP3 inflammasome activation and the subsequent secretion of IL18, which markedly prevented oxaliplatin-induced mechanical hyperalgesia in mice. These results identify a role for NET-triggered NLRP3 activation and IL18 release in the development of OIPN and suggest that utilizing IL18BP and EPA could be effective treatments for OIPN.
Protection of Regulatory T Cells from Fragility and Inactivation in the Tumor Microenvironment
Authors: Zhang Hongru , Tomar Vivek S. , Li Jinyang , Basavaraja Raghavendra , Yan Fangxue , Gui Jun , McBrearty Noreen , Costich Tara Lee , Beiting Daniel P. , Blanco M. Andres , Conejo-Garcia Jose R. , Saggu Gurpanna , Berger Allison , Nefedova Yulia , Gabrilovich Dmitry I. , Fuchs Serge Y. 
Published: October 2022

Abstract

Fragility of regulatory T (Treg) cells manifested by the loss of neuropilin-1 (NRP1) and expression of IFNγ undermines the immune suppressive functions of Treg cells and contributes to the success of immune therapies against cancers. Intratumoral Treg cells somehow avoid fragility; however, the mechanisms by which Treg cells are protected from fragility in the tumor microenvironment are not well understood. Here, we demonstrate that the IFNAR1 chain of the type I IFN (IFN1) receptor was downregulated on intratumoral Treg cells. Downregulation of IFNAR1 mediated by p38α kinase protected Treg cells from fragility and maintained NRP1 levels, which were decreased in response to IFN1. Genetic or pharmacologic inactivation of p38α and stabilization of IFNAR1 in Treg cells induced fragility and inhibited their immune suppressive and protumorigenic activities. The inhibitor of sumoylation TAK981 (Subasumstat) upregulated IFNAR1, eliciting Treg fragility and inhibiting tumor growth in an IFNAR1-dependent manner. These findings describe a mechanism by which intratumoral Treg cells retain immunosuppressive activities and suggest therapeutic approaches for inducing Treg fragility and increasing the efficacy of immunotherapies.
Rates of Intracoronary Imaging Optimization in Contemporary Percutaneous Coronary Intervention: A Report From the BMC2 Registry
Authors: Madder Ryan D. , Seth Milan , Sukul Devraj , Alraies M. Chadi , Qureshi Mansoor , Tucciarone Michael , Saltiel Frank , Qureshi M. Imran , Gurm Hitinder S. 
Published: October 2022

Background:
Intracoronary imaging (ICI) during percutaneous coronary intervention (PCI) improves outcomes, yet hospital- and physician-level variabilities in ICI and its impact on ICI use in contemporary PCI remain unknown. This study was performed to evaluate hospital- and physician-level use of ICI to optimize PCI.

Methods:
Using data from a large statewide registry, patients undergoing PCI between July 2019 and March 2021 were studied. The primary measure of interest was ICI (intravascular ultrasound or optical coherence tomography) optimization during PCI. A fitted hierarchical Bayesian model identified variables independently associated with ICI optimization. The performing hospital and physician were included as random effects in the model.

Results:
Among 48 872 PCIs, ICI optimization was performed in 8094 (16.6%). Median [interquartile range] hospital- and physician-level frequencies of ICI were 8.8% [3.1%, 16.0%] and 6.1% [1.1%, 25.0%], respectively. Bayesian modeling identified left main PCI (adjusted odds ratio [aOR], 4.41; 95% credible interval [3.82, 5.10]), proximal left anterior descending artery PCI (aOR, 2.28 [2.00, 2.59]), PCI for in-stent restenosis (aOR, 1.55 [1.40, 1.72]), and surgical consult prior to PCI (aOR, 1.21 [1.07, 1.37]) as independent predictors of ICI optimization. The hospital-level median odds ratio, an estimate of the contribution of inter-hospital variability in odds of ICI use, was 3.48 (2.64, 5.04). Physician-level median odds ratio was 3.81 (3.33, 4.45).

Conclusions:
Substantial hospital- and physician-level variation in ICI was observed. Except for performance of left main PCI, the hospital and physician performing the PCI were more strongly associated with ICI optimization than any patient or procedural factors.
Quantification of underwater calling and foraging activities in the African clawed frog Xenopus laevis
Authors: Lorrain-Soligon Léa , Secondi Jean 
Published: October 2022

Abstract
Aquatic anuran species are difficult to detect and observe and this is a major limit to the study of their behaviour and ecology. This habit limits the direct monitoring of sexual and foraging activity, and the investigation of how environmental factors influence their expression as well as how individuals allocate time between competing activities. We investigated this issue in Xenopus laevis, a mostly aquatic frog that forages and emits calls underwater. This model species in biology has been extensively studied in the lab but its behaviour in nature remains poorly described. We carried out a study in a pond during the breeding season in the French invasive range. We recorded underwater vocal activity as a proxy for sexual activity using a hydrophone, set food-baited traps to quantify foraging activity, and recorded environmental conditions (moonlight intensity, temperature and rainfall) over two lunar cycles. We found that individuals engage in these two activities during the breeding season. At the peak of the breeding period, vocal activity was expressed during the day. The investment in reproduction (calling activity) may reduce the time allocated to foraging on a circadian scale. The two activities seem to be partitioned depending on moonlight intensity, with a stronger effect on males. Foraging activity decreased and vocal activity increased when moonlight intensity increased. We also observed a negative effect of temperature and a positive effect of rainfall on vocal activity only. Our method is promising to monitor the activity of other aquatic anurans.
Diasporic Chinese Boundaries and Bonds Revisited: An Introduction to the Special Issue
Authors: Yow (游俊豪) Cheun Hoe 
Published: October 2022

Abstract
Over myriads of migration trajectories, settlement adaptations, and generation variations, diasporic Chinese have constantly reconfigured their subjectivities as a group, locally, regionally, and globally. Either as migrants transcending geographic demarcations and territories or ethnic groups with distinctive cultures and mentalities, members of the Chinese diaspora have aspirations and concerns that have evolved over time and space. This special issue re-examines and reconceptualizes boundaries and bonds of Chinese diaspora in various realms and aspects. It features six revised papers, from an international conference on “Boundaries and Bonds” held in October 2021, and an article that shares the same academic concern. They are riveting accounts of how multiple disciplines should be engaged in order to approach Chinese diaspora as subject matter and to reveal the diversity of situations where Chinese as migrants and ethnic groups are positioned and constructed for a myriad of reasons. Their case studies on Guangdong, Brazil, Singapore, Australia, Indonesia, Malaysia, and Myanmar reveal the various processes and routes of resetting networks and boundaries that have brought about new elements of Chinese ethnicity.
Paradox of Superdiversity: Contesting Racism and “Chinese Privilege” in Singapore
Authors: Liu (刘宏) Hong , Huang (黄伶俐) Lingli 
Published: October 2022

Abstract
Large-scale immigration has turned Singapore into a highly diverse setting, where migrants and local-born Singaporeans encounter one another on a daily basis. In the past decade, the city-state has seen rising debates and contestations over racism, despite being known as a racially harmonious society. This article situates the public discourse on racism and “Chinese privilege” in the context of superdiversity and examines its wider implications for theorization and policy. Approaching the paradox of superdiversity from a political economy perspective, we investigate how three sets of factors have contributed to the rising public discourse on racism not only between migrants and locals but also among local-born Singaporeans: i) immigration regime and the strategy toward a knowledge economy, ii) new patterns of electoral politics, and iii) the impacts of China’s growing influences in Southeast Asia. This article offers two broader theoretical implications for the scholarship on migration and race relations in a context of superdiversity. First, the paradoxical co-existence of superdiversity and racism obtains not only between migrants and natives, as many studies have shown, but also between native races in the host society. Second, diversifications and new forms of contestations and racism are not only a result of the immigration regime and domestic politics of the host country, but are also shaped by the international political economy, as evidenced by the way in which the rise of China has intensified contestations on race relations in Singapore.
Hobbes on Public Ministers
Authors: Miller Jonah 
Published: October 2022

Abstract
Until recently, scholars paid relatively little attention to chapter 23 of Leviathan, in which Hobbes discussed “the public ministers of sovereign power.” In the past few years, however, political theorists have used chapter 23 extensively in discussions of Hobbes’ concept of the state. But what was the significance of the chapter in its own time? This article suggests it served two purposes. First, it allowed Hobbes to bolster and elaborate arguments made elsewhere in Leviathan. Second, it responded to 1640s debates between royalists and parliamentarians over the role of subordinate magistrates in a polity. By the time Leviathan was published in 1651 these debates were no longer pressing, which explains the chapter’s rapid descent into obscurity. Nonetheless, recovering this polemical context helps to understand the genesis of this small but significant part of Hobbes’ political thought.
The Waste Land 100 Years On
Authors: Vanheste Jeroen 
Published: October 2022

Abstract
Over the past century, there have been remarkable changes in the appreciation of T.S. Eliot (1888–1965). From the interwar years up to the 1950s, he was for decades an icon of high culture and outstanding moral values, of everything that is beautiful and good and deserves admiration; while from the 1970s onwards he became a symbol of a completely different kind: one of elitism and conservatism, of everything that is wrong and deserves condemnation. Over the past twenty years, gradually a more balanced view has been established. In this article I outline this development, relate it to general changes in the cultural climate, and argue that, a hundred years after publication of his major poem The Waste Land (1922), T.S. Eliot remains highly significant to us both as a poet and a cultural critic.
Is it Possible to Maintain Information Flow in Japanese into Thai Translation? A Study of Connecting Clauses
Authors: Chawengkijwanich Somkiat 
Published: October 2022

Abstract
This paper investigates the ordering of connecting subordinate and coordinate clauses in Japanese-Thai translation to examine whether it is possible to maintain information flow from the source text. Japanese preposed clauses were translated using both preposed and postposed clauses in the Thai translated text. Preposed clauses were used widely when they provided: 1) listed information; 2) grounded information for comprehending main clauses; 3) the framework within which main clauses are held; 4) temporal sequences; and 5) information linking prior context to a new discourse topic. Postposed clauses were used mainly to modify main clauses. In cases where clauses provided the information needed to comprehend subsequent clauses, professional translators attempted to place the clause sentence initially, despite a preference for sentence-final occurrence arising from Thai syntactic constraints. This demonstrated norms in Japanese-Thai translation in terms of awareness among professional translators of the significance of information flow in the source text.
Transitivity System and a Translation of Lexical Metaphors: The Case of the Emirates Airline Website
Authors: Chueasuai Pasakara 
Published: October 2022

Abstract
Lexical metaphors colourise literary as well as non-literary texts. In the case of a website, it can make the text more appealing and consequently improve the sales of a company. In the highly competitive airline industry, an impressive webpage plays a significant role, especially in online reservation and purchase. This article examines the lexical metaphors used in the English and Thai websites of the Emirates Airline, adopting Transitivity of the Systemic Functional Linguistics by Eggins (2004) as the analytical framework. It also explores how the translated lexical metaphors are similar to and/or different from the original version. The study finds the lexical metaphors are realised in the transitivity systems of process, participant and circumstance. The translation is found to retain mostly the original transitivity systems. The study further finds both literal translation and adaption play parts in preserving and removing the original metaphorical form.
Danish Attempts to Open Trade with Japan, 1637–1645
Authors: Karlsmose Mathias Istrup 
Published: October 2022

Abstract
This article will describe the first attempt made by the Danish East India Company to establish trade with Japan in 1637–1645, as described in Dutch and Portuguese sources. In doing this, it will contribute to a rich historiography of early modern European contacts with Japan. In English-language historiography on seventeenth-century maritime East Asia, the Danish East India Company has largely been overlooked as an actor compared to its larger European counterparts. Conversely, in Danish historiography the interactions between the Danish company and its larger competitors, especially the Dutch, have been overlooked as well. The article will show how the governor of the Danish East India Company tried to cooperate with the Spanish and Portuguese in bypassing the Dutch monopoly in Japan. In addition, it will show how the Japanese relied on Dutch intelligence on the outside world.
A Study of Aromatic Woods in Seventeenth-Century India: Circulation of Aloewood and Sandalwood through Facilitating Port Cities and Trade Networks
Authors: Chattopadhyay Amrita 
Published: October 2022

Abstract
During the seventeenth century, various commodities carved out an economic sphere for themselves across the littoral parts of the Indian Ocean through the interconnectedness of its port cities. The present article focuses on two significant aromatic woods: aloewood and sandalwood, both plant-based materials, and locates them as “commodities” in commercial networks across the maritime space. Various port cities like Surat, Patna, Mausalipatam and Cambay, all central to the trading activities of the European companies, served as chief nodes in the grid of circulation that enabled their mobility, value addition and economic exchanges. Revisiting English factory records, Dutch East India Company documents and European travel accounts, this article explores the neglect of ephemeral objects in the material hierarchy of trading items. It also accounts for the thriving presence of these aromatic woods in the Indian Ocean maritime networks as two key materials in European trading interests and as facilitators of the early modern economy.
A training programme for community pharmacists to support people living with severe and persistent mental illness: Intervention mapping in the context of a pandemic
Authors: McMillan Sara S , El-Den Sarira , O’Reilly Claire L , Roennfeldt Helena , Theodorus Theo , Chapman Justin , Bailey Kylie , Crump Keith , Collins Jack C , Ng Ricki , Stewart Victoria , Wheeler Amanda J 
Published: October 2022

Objective: The Bridging the Gap Between Physical and Mental Illness in Community Pharmacy ( PharMIbridge) randomised controlled trial (RCT) aims to test the effectiveness of a pharmacist-led support service in improving medication adherence, and the physical and mental health of people living with severe and persistent mental illness compared to a standard medication review service. Method: Using the six-step intervention mapping (IM) framework, this paper describes the development and content of the PharMIbridge pharmacist training programme, an integral part of the RCT implementation, and continuous adaptations made to the process to keep pace with the evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in Australia. A Training Working Group comprising health educators, practitioners, mental health consumers and researchers, refined the programme objectives and assisted with developing content and troubleshooting issues related to training delivery for pharmacists randomised to the RCT intervention arm. Results: A 2-day training programme was developed, which included Mental Health First Aid, simulated patient role-plays, and four pre-recorded modules using lectures, demonstration case vignettes, role-play activities and discussion. The programme, co-facilitated by project team members and mentors (pharmacist and consumer educators), aims to enhance pharmacists’ mental health literacy, skills and confidence and empower them to engage with this vulnerable population using a strengths-based approach. Pre- and post-training questionnaires and interviews will be used to evaluate the impact of the PharMIbridge training programme. Conclusion: The systematic stepwise method provided by the IM framework highlights the solution-focused approach adopted by the project team and characteristics including adaptability and resilience which enabled training development and implementation across four Australian regions during the SARS-CoV-2 pandemic.
Politeness as a Cultural Aspect in Japanese and Turkish Languages
Authors: Tekmen Ayşe Nur 
Published: October 2022

AbstractVarious studies have been made on different aspects of the Turkish and Japanese languages, but comparative studies between the two languages are still limited. The aim of this study is to describe the politeness strategy of these two languages from a cultural perspective within the paradigm of cognitive linguistics. Both Turkish and Japanese are agglutinative languages, and speakers of both languages prefer the subjective construal. So, if the typology of a language might be related to its perception, the conceptualization of ‘polite’ and the perception of politeness in that language may be alike.