bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of androgen receptor expression with glucose metabolic features in triple-negative breast cancer
Authors: Lee Reeree , Lee Han-Byoel , Paeng Jin Chul , Choi Hongyoon , Whi Wonseok , Han Wonshik , Seok Ju Won , Kang Keon Wook , Cheon Gi Jeong 
Published: September 2022

Background
Androgen receptor (AR) is a potential therapeutic target in triple-negative breast cancer (TNBC). We aimed to elucidate the association of AR expression with glucose metabolic features in TNBC.

Methods
Two independent datasets were analyzed: FDG PET data of our institution and a public dataset of GSE135565. In PET analysis, patients with TNBC who underwent pretreatment PET between Jan 2013 and Dec 2017 were retrospectively enrolled. Clinicopathologic features and maximum standardized uptake value (SUVmax) of tumors were compared with AR expression. In GSE135565 dataset, glycolysis score was calculated by the pattern of glycolysis-related genes, and of which association with SUVmax and AR gene expression were analyzed.

Results
A total of 608 female patients were included in the PET data of our institution. SUVmax was lower in AR-positive tumors (P < 0.001) and correlated with lower AR expression (rho = –0.26, P < 0.001). In multivariate analysis, AR was a deterministic factor for low SUVmax (P = 0.012), along with other key clinicopathologic features. In the GSE135565 dataset, AR expression also exhibited a negative correlation with SUVmax (r = –0.34, P = 0.001) and the glycolysis score (r = –0.27, P = 0.013).

Conclusions
Low glucose metabolism is a signature of AR expression in TNBC. It is suggested that evaluation of AR expression status needs to be considered in clinical practice particularly in TNBC with low glucose metabolism.
Quem quer ir para Loco Lândia?
Authors: Mathias Nicoli Maziero , Berselli Marcia 
Published: September 2022

Este artigo apresenta uma pesquisa que tem como tema a mediação da professora-personagem em um processo de Drama na escola. A partir do estudo desta abordagem artístico pedagógica busca-se responder como a professora-personagem pode estimular o ensino-aprendizagem de modo sensível durante um processo de Drama na escola. O artigo propõe a análise de aspectos do processo Loco Lândia: O Planeta dos Memes, desenvolvido com crianças do quarto ano do Ensino Fundamental na EMEF Lívia Menna Barreto (Santa Maria – RS) durante o ano de 2019. Embasando as teorias sobre o Drama, o referencial teórico está centrado nos autores Cabral (2006), Pereira (2015) e Vidor (2012). A partir de estratégias específicas do Drama, observa-se como essa abordagem de ensino e experimentação do teatro pode promover uma mediação mais sensível, atenta aos diversos tempos, saberes e interesses dos e das estudantes.
Межмуниципальные различия в цифровой восприимчивости населения
Authors: Михайлова Анна Алексеевна 
Published: September 2022

Рост числа пользователей интернета и мобильной связи оказал глобальное влияние на общественные процессы. Цифровизация стала новым фактором деформации мирового пространства и стратификации общества. Однако господствующий детерминизм социально-экономических и технологических причин цифрового неравенства не способствует учету индивидуальных причин и локальных условий цифровизации. Цель статьи — оценить пространственную неоднородность цифровизации, фокусируясь на поиске территориальных различий в способности и готовности населения к широкому усвоению навыков использования цифровых технологий с последующим внедрением в повседневную жизнь. Статья основана на материалах опроса 876 жителей 22 муниципалитетов Калининградской области (август 2020 г.). Определены сходства и различия между центром и периферией в восприимчивости населения к цифровым технологиям, локальным цифровым сервисам, сетевому обществу и цифровым коммуникациям. Выявлен сходный высокий уровень востребованности цифровых сервисов, позволяющих осуществлять повседневные рутины (оплата счетов, получение госуслуг, проверка социальных сетей и др.). Показаны территориальные различия в проникновении личностно ориентированных цифровых технологий и услуг, а также локальных цифровых сервисов, зависящих от местной инфраструктуры и рынка труда. Даны рекомендации по повышению связанности Калининграда и прочих муниципалитетов региона на основе более широкого внедрения цифровых технологий и поддержке их аналоговыми решениями.

Благодарность. Исследование выполнено при финансовой поддержке гранта РФФИ, проект № 20-011-32062.
В объятьях картонных богов: о магии имен, силе слов и фетишизме символического в социальной жизни. Часть I
Authors: Подвойский Денис Глебович 
Published: September 2022

В настоящем научно-публицистическом очерке предметом критического анализа становится феномен символического фетишизма как одно из закономерных проявлений и последствий универсального процесса социального конструирования реальности. Коллективное (вос)производство и артикуляция смыслов/ценностей в формах совместной человеческой деятельности и общественного сознания сопровождаются (вос)производством знаково-символических систем, составляющих важную компоненту объективированного универсума социальной жизни. Символическая система общества приобретает значительную автономию (по отношению к конкретным индивидам), формируя опредмеченную, овеществленную среду духовной и материальной культуры, в масштабах которой разворачиваются жизнь и деятельность социальных акторов. Трактовка указанной темы выстраивается на базе авторской рецепции трех концептуальных источников: 1) теории проводников взаимодействия П.А. Сорокина (рассматривается в первой части статьи), 2) теории символического капитала и символического насилия П. Бурдьё (включающей размышления о «власти номинации» и ее роли в конституировании социальных отношений), а также 3) представлений Ж. Бодрийяра о знаковой природе потребления в обществах последних десятилетий XX — начала XXI века (обсуждаются во второй части очерка).
Статья публикуется в двух частях. Окончание — в № 5 за 2022 год.
Selective application of navigation templates in idiopathic scoliosis: technical and hronometric features
Authors: Kosulin A. V. , Elyakin D. V. , Kornievskiy L. A. , Bulatova I. A. , Mushkin A. Yu. 
Published: September 2022

Objective. To evaluate short-term result of selective navigation templates application in idiopathic scoliosis surgery.Material and Methods. A total of 12 patients aged 14–17 years with idiopathic scoliosis were included in the study. Group A included 6 patients treated with selective application of navigation templates for pedicle screws insertion in the most difficult zones. Group B (control) included 6 patients in whom all the pedicle screws were placed with free-hand technique. Number of screws inserted was 16–20 per patient. There was no significant difference between the groups in sex, age, Cobb angle, number of vertebrae instrumented, number of pedicle screws and laminar hooks. Surgery duration, blood loss, absolute and relative correction were compared. In Group A, duration of the 3D-objects fabrication and printing, as well as pedicle screw accuracy based on 2-mm increment grading system were evaluated.Results. Selective application of navigation templates as compared with total free hand screws placement significantly reduced surgery duration. Difference in blood loss and deformity correction was not significant. A total of 107 pedicle screws were placed in Group A, 48 of them with navigation templates and 59 by free-hand technique. Average pedicle width in screw installation with navigation templates was 4.28 ± 1.43 mm, and in that with free-hand technique 6.53 ± 1.72 mm, with significant difference. Accurate screw placement with navigation templates and by free-hand technique were 93.7 % and 88.0 %, respectively, with no significant difference. Duration of 3D-objects manufacturing was 1419 ± 190 minutes. Active operator’s involvement was required in about 10 % of the while.Conclusion. Selective application of a pair of two-level navigation templates for most difficult pedicles in idiopathic scoliosis significantly reduces surgery duration. Difference in blood loss and deformity correction is insignificant. Refusal of total templates usage for combination of navigation templates for selected difficult pedicles and free-hand technique for the rest is an option for shortening the preoperative preparation, but provides screw placement accuracy comparable with total templates usage (92.5–97.6 % as reported).
Uwarunkowania dobrowolnych odejść z pracy w polskich przedsiębiorstwach w kontekście segmentacji rynku pracy
Authors: Arendt Łukasz , Grabowski Wojciech 
Published: September 2022

W artykule omawiane jest zagadnienie dobrowolnego zwalniania się z pracy w polskich przedsiębiorstwach w kontekście koncepcji segmentacji rynku pracy. Celem artykułu jest ustalenie, jak segmentacja rynku pracy, określona przez liczbę segmentów stanowisk pracy w przedsiębiorstwach, determinuje częstotliwość dobrowolnego odchodzenia z przedsiębiorstwa przez osoby w nim zatrudnione, a także identyfikacja wpływu innych czynników związanych z organizacją, środowiskiem pracy i cechami osób zatrudnionych na intensywność dobrowolnej rotacyjności w Polsce. W badaniu sformułowano dwa problemy: czy liczba segmentów pracy wewnątrz przedsiębiorstwa wpływa na skalę dobrowolnej rotacyjności w polskich firmach? czy zależność między cechami miejsca pracy a skłonnością do dobrowolnego odejścia z pracy różni się ze względu na segmenty? Wykorzystując dane pochodzące z badania CAWI przeprowadzonego na próbie 1002 polskich firm do oszacowania wielomianowego modelu probitowego, weryfikacji poddano dwie hipotezy: struktura segmentacji stanowisk pracy warunkuje skłonność do dobrowolnych odejść z pracy; determinanty dobrowolnej rotacyjności związane z cechami stanowiska pracy są zróżnicowane pomiędzy segmentami. Wyniki badania empirycznego wskazują, że czynniki strukturalne są głównymi determinantami skłonności do dobrowolnego zwalniania się z pracy, jednakże ich wpływ zależy od segmentu, do którego należy pracownik – tym samym potwierdzono hipotezę drugą. Liczba segmentów rynku pracy okazuje się determinować skłonność do dobrowolnego odchodzenia z pracy jedynie w przypadku pracowników z segmentu pierwotnego, co potwierdza prawdziwość hipotezy pierwszej jedynie częściowo. Główne czynniki wpływające na skłonność do dobrowolnego zwalniania się z pracy są związane z satysfakcją z wykonywanego zajęcia – należy w związku z tym wskazać na ważną rolę działów personalnych oraz praktyk zarządzania w redukcji skali dobrowolnego odchodzenia z pracy w Polsce i innych krajach charakteryzujących się niedoborami po stronie podażowej.
Tourism, commodification of Dongba script and perceptions of the Naxi minority in the linguistic landscape of Lijiang: a diachronic perspective
Authors: Nie Peng , Yao Xiaofang 
Published: September 2022

Abstract
Ongoing debates in the field of sociolinguistics are centred around the implications of the commodification of the languages and cultures of ethnic minorities. Previous research has adopted synchronic approaches to describing how ideologies of tourist consumption shape language choices in the linguistic landscape. However, such snapshot analyses have proved to be inadequate in revealing changes in the linguistic landscape over time, especially the nuanced perceptions of minority communities who are subjects to ethnic tourism. This paper examines the use of Dongba script in the linguistic landscape of the Naxi minority in Lijiang under the conditions of commodification in tourism. A diachronic comparison of photographic data collected in 2016 and 2021 revealed the increasing visibility and prominence of Dongba script on public signs; interviews with ordinary inhabitants, tourism industry practitioners and Dongba priests within the Naxi community further demonstrated the evolving attitudes towards linguistic commodification, from hesitation and objection to integration and creative accommodation. The study provides new insights into how a diachronic perspective can help reveal the dynamic between packaging languages as commodities and retaining signs of identity, religion and culture.
Contributions of morphological awareness and lexical inferencing ability to L2 vocabulary knowledge among Chinese EFL learners: a structural equation modeling analysis
Authors: Wang Tuoxiong , Zhang Haomin 
Published: September 2022

Abstract
The present study investigated the direct and indirect contributions of morphological awareness to vocabulary knowledge among a group of Chinese English as a foreign language (EFL) students in a university in China. Using multiple regression analysis and structural equation modeling analysis, the study found that morphological awareness made significant contributions to vocabulary knowledge after lexical inferencing was controlled for. To be more specific, the prediction of morphological awareness on vocabulary depth was stronger than its prediction on vocabulary breadth. The direct effects of morphological awareness were stronger than its indirect effects on vocabulary. More importantly, the study revealed that the relationships between morphological awareness (morpheme recognition and morpheme discrimination) and vocabulary knowledge were mediated by discourse clues rather than grammar clues.
Smartphone apps for spiritual wellness
Authors: Gorichanaz Tim 
Published: September 2022

Abstract
Smartphone applications (apps) to promote wellness constitute a burgeoning industry, part of broader societal developments in “digital wellness.” This paper examines the affordances and interaction styles in a selection of apps that support spiritual wellness, which is a foundational and scarcely acknowledged dimension of wellness. Spiritual wellness itself entails six dimensions: belief in an organizing force, connectedness, faith, compassion, meaning of life, and meaning of death. This paper surveys the smartphone applications currently available that support spiritual wellness and discusses how these apps relate to the six aspects of spiritual wellness, discussing one application in depth for each aspect. In all, the surveyed apps employ a small set of interaction styles, including: timers, notifiers, card decks, and journals. This framework contributes to our understanding of the space of spiritual digital wellness applications. Opportunities for further development and engagement in each aspect are discussed.
A Hybrid Approach to the Digital Restoration of Large or Damaged Works of Art
Authors: Frost Francis 
Published: September 2022

Abstract
This paper will discuss the issues faced by the Rhode Island Historical Society (RIHS) in deciding how to handle the conservation and restoration needs of a very large and damaged work in their collection, and describe the innovative solution they came up with. The RIHS faced the decision of how to approach possible restoration of an 1812 painted drop scene or theater curtain, which had been conserved in the 1980s but was by now in need of cleaning and perhaps further restoration, to help celebrate the organization’s bicentennial in 2022. They had to decide what the limits of traditional restoration were for their object, if this restoration might significantly affect the integrity of the work, and whether the considerable cost of traditional restoration was too prohibitive for a smaller institution. In considering these questions the RIHS came to the conclusion that an alternative method of restoring a work such as theirs was needed, a method that would allow an institution to create a digital file of the work, and to “restore” it using a combination of photo-editing tools and traditional painting methods. Digital photo-editing on its own would not have been sufficient to produce an organic, realistic restoration of the work, and using this hybrid digital approach, which did not alter the original object in any way, was the ideal solution.
Der Thatcherismus und Andrew Lloyd Webbers Musicals
Authors: Eubanks Winkler Amanda 
Published: September 2022

Abstract
Dieser Aufsatz umreißt die zentralen Grundsätze des Thatcherismus und geht der Frage nach, ob und wie sie in Andrew Lloyd Webbers Œuvre der 1980er Jahre inszeniert wurden. Die Autorin konzentriert sich auf drei Musicals, die oft mit Thatcheristischer Ästhetik in Verbindung gebracht wurden: „Cats“ (1981), „Starlight Express“ (1984) und „Das Phantom der Oper“ (1986). Der Beitrag zeigt, wie die Musiksprache und Dramaturgie dieser Musicals an größeren kulturellen, vom Thatcherismus geprägten Diskursen partizipierten, die „traditionelle Werte“ lobten und von einer „glorreichen“ britischen Vergangenheit schwärmten, die ihre Stimme gegen Elitedenken erhoben und die die Wahrnehmung der Rolle des Staats und die Beziehung zwischen dem Individuum und dem Staat verschoben.
Artivismo con humor en Las miserables de Las Reinas Chulas
Authors: Vincent Nidia 
Published: September 2022

Este artículo es un acercamiento a la temática, construcción y recursos humorísticos de la obra Las miserables (2016) de la compañía Las Reinas Chulas, con el objeto de reconocer al cabaret y el humor como recursos de un artivismo que puede incidir en cambios culturales, políticos o sociales. Esta compañía es un referente obligado para comprender y valorar al teatro-cabaret contemporáneo mexicano que se ha caracterizado, desde sus orígenes en los años 80, por su crítica creativa y compromiso con los feminismos y la comunidad LGTB+. Teniendo como telón de fondo la Revolución Francesa, la obra se refiere a los derechos de las mujeres, la diversidad sexual y la violencia de género. Su oportuno estreno en 2016, coincidió con las discusiones para la redacción de la actual Constitución de la Ciudad de México.
AP2 Regulates Thickveins Trafficking to Attenuate NMJ Growth Signaling inDrosophila
Authors: Choudhury Saumitra Dey , Dwivedi Manish Kumar , Pippadpally Srikanth , Patnaik Abhinandan , Mishra Shirish , Padinjat Raghu , Kumar Vimlesh 
Published: September 2022

AbstractCompromised endocytosis in neurons leads to synapse overgrowth and altered organization of synaptic proteins. However, the molecular players and the signaling pathways which regulate the process remain poorly understood. Here, we show that σ2-adaptin, one of the subunits of the AP2-complex, genetically interacts with Mad, Medea and Dad (components of BMP signaling) to control neuromuscular junction (NMJ) growth inDrosophila. Ultrastructural analysis ofσ2-adaptinmutants show an accumulation of large vesicles and membranous structures akin to endosomes at the synapse. We found that mutations inσ2-adaptinlead to an accumulation of Tkv receptors at the presynaptic membrane. Interestingly, the level of small GTPase Rab11 was significantly reduced in theσ2-adaptinmutant synapses. However, expression of Rab11 does not restore the synaptic defects ofσ2-adaptinmutations. We propose a model in which AP2 regulates Tkv internalization and endosomal recycling to control synaptic growth.
Motivasi Belajar dalam Memediasi Pengaruh Lingkungan Teman Sebaya, Kondisi Ekonomi Orangtua terhadap Prestasi Belajar
Authors: Murni Murni , Fachrurrozie Fachrurrozie 
Published: September 2022

The purpose of this study was to determine the direct influence of the peer environment and the economic conditions of parents through learning motivation on students' accounting learning achievement. The population in the study was students of class 10 Accounting in Batang Regency, which amounted to 143 students. Data was taken by questionnaire. Data were analyzed by descriptive statistical analysis and multiple linear regression analysis. path analysis, and hypothesis testing, namely t test and Sobel test. The results showed: (1) peer environment has a positive and significant effect on learning achievement; (2) parents' economic conditions have no effect on learning achievement, (3) learning motivation has a positive and significant effect on learning achievement, (4) peer environment has a positive and significant effect on learning motivation, (5) parents' economic conditions have no effect on learning motivation , (6) peer environment has a positive and significant effect on achievement through learning motivation, and (7) parents' economic conditions have no effect on learning achievement through learning motivation.
METODOLOGÍA FEMINISTA Y PARTICIPATIVA EN CÁRCELES DE ARGENTINA Y MÉXICO
Authors: Actis María Florencia , Arens Juliana Inés 
Published: September 2022

El artículo reflexiona en torno a los aportes académicos y sociales de lo que se llama una metodología feminista y participativa; es decir, aquella que articula fundamentos de la teoría de género con perspectivas críticas latinoamericanas —Investigación-Acción Participativa (IAP) y educación popular—. Para ello, describe y analiza dos investigaciones de campo en cárceles femeninas de Argentina y México (2015-2020). Entre los hallazgos, se destaca el valor crítico y la posibilidad transformadora de dicha metodología en la cotidianeidad de las mujeres presas.
LA INTERCULTURALIDAD EN LA PRODUCCIÓN CIENTÍFICA DE ACADÉMICOS ECUATORIANOS
Authors: Mantilla Jorge , Mila Frank , Mantilla Belén 
Published: September 2022

El objetivo del presente artículo es desarrollar una revisión sobre el aporte de la academia ecuatoriana al estudio de la interculturalidad dentro de las bases académicas Scopus y Web of Science, en torno a cuatro puntos: cantidad, impacto, colaboración y temáticas. La metodología implementada consistió en un análisis bibliométrico empleando el paquete bibliometrix en R. El análisis muestra que, dentro de estos espacios, el desarrollo del estudio de la interculturalidad no se encuentra lo suficientemente desarrollado en comparación con su relevancia social. Sin embargo, existen dinámicas y proyecciones de crecimiento, diversificación y generación de espacios colaborativos.
Las funciones administrativas y curriculares en la gestión de los Centros Educativos Unidocentes
Authors: ALVARADO BARBOZA MARCO ANTONIO 
Published: September 2022

Los Centros Educativos Unidocentes (CEU) forman parte del sistema educativo costarricense y constituyen una estrategia relevante para ampliar la cobertura educativa en las zonas rurales y de difícil acceso. Para la gestión administrativa y curricular de los CEU el Ministerio de Educación Pública (MEP) designa a un docente, que no cuenta, necesariamente, con formación ni experiencia en el área de la administración de la educación. Ante esta situación, este artículo tiene como objetivo analizar las debilidades y fortalezas que presentan estos docentes en el desarrollo de funciones administrativas y curriculares para la gestión de estos centros educativos unidocentes. El artículo se desarrolla a través de cuatro apartados: en el primero denominado introducción, se plantea la relevancia de los CEU como estrategia del SE para para ampliar la cobertura educativa en las zonas rurales y de difícil acceso. En el segundo apartado se establecen los fundamentos teóricos referentes a la gestión de los centros educativos unidocentes. En el tercer apartado se realiza un análisis de las fortalezas y debilidades en el área curricular y administrativa de los CEU y en el cuarto apartado se establecen las conclusiones finales. Para ello, se realizó un cuestionario a todos los docentes encargados de CEU de la DRE de Cartago del MEP, así como entrevistas semiestructuradas a tres docentes de diferentes circuitos de la misma regional. Como hallazgos principales se destaca que este tipo de CEU tienen diferentes fortalezas y debilidades dependiendo del contexto donde se encuentren y de la propia gestión del docente encargado. Aspectos como la lejanía y el acceso, las condiciones socioeconómicas y educativas de la población estudiantil, la capacitación docente, el apoyo del supervisor y el excesivo recargo de funciones influyen para decidir si algunas categoría son consideradas como debilidad o fortaleza.