bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of ezetimibe on risks of various types of cancers: a meta-analysis and systematic review
Authors: Huang Jing , Li Huijing , Wang Xueqi , Liang Xi , Zhao Tianhe , Hu Jingnan , Bai Haiyan , Ge Jianli , Sun Shijiang , He Jianming 
Published: March 2022

Background
Ezetimibe is a widely used medication to reduce the plasma cholesterol level, particularly low-density lipoprotein level. However, its impact on cancer remains controversial. Here, its impacts on risks of various types of cancers were meta-analyzed.

Methods

PubMed and Cochrane Library electronic databases were searched and randomized controlled trials with followed up for at least 24 weeks were selected and included. The experimental group was defined as those patients treated with ezetimibe alone or with other medications, and the control group was defined as those who received a placebo or the matched medication. The number of new cancer cases or cancer-related deaths was extracted. Statistical analysis was performed using Review Manager (version 5.3).

Results
Nine trials enrolling 35 222 patients were included in the analyses. Compared with the control group, ezetimibe increased the number of new intestine cancer patients [relative risk (RR), 1.30; 95% confidence interval (CI), 1.02–1.67; P = 0.03] and had a trend to increase the number of new breast cancer patients (RR, 1.39; 95% CI, 0.98–1.98; P = 0.07). There was no significant difference in new hepatobiliary cancer, prostate cancer, skin cancer or cancer of other sites. Ezetimibe did not significantly increase the risk of new cancer in total (RR, 1.03; 95% CI, 0.96–1.11; P = 0.38), cancer-related death (RR, 1.11; 95% CI, 0.98–1.26; P = 0.10) or cancer events (RR, 1.04; 95% CI, 0.97–1.12; P = 0.30). In terms of lipid-lowering effect, ezetimibe significantly reduced total cholesterol and low-density lipoprotein cholesterol, increased high-density lipoprotein cholesterol.

Conclusion
Ezetimibe may increase the risk of intestine cancer and has a trend of increasing the risk of breast cancer. There is no evidence to support that it increases or decreases the risk of other types.
Immunogenicity and safety of a bivalent, adjuvant system 04–adjuvanted human papillomavirus vaccine in healthy female volunteers aged 15–25: a randomized, double-blind, phase III, noninferiority clinical trial
Authors: Afshani Seyyedeh Maryam , Mirhassani Reihaneh , Hosseini Hamed , Hosseini Reihaneh , Tehranian Afsaneh , Malekzadeh Reza , Ostovar Afshin , Abdolghaffari Amir Hossein , Ghobadi Mohammad Amin , Hedayatjoo Behnaz , Hazegh Fetratjoo Delara , Rezagholi Zahra , Anari AmirHossein , Moini Ashraf 
Published: March 2022

Objective
Vaccination is proven to significantly reduce the risk of human papillomavirus (HPV)–related complications, especially cervical cancer. This study aimed to assess the immunogenicity and safety of the investigational bivalent HPV vaccine (16/18), named Papilloguard (Noyan Pajouhan Biopharma, Tehran, Iran), in comparison with the reference product (Cervarix, bivalent HPV vaccine (16/18) manufactured by GlaxoSmithKline, Rixensart, Belgium) in a three-dose regimen.

Methods
This trial was a randomized, controlled, double-blind, phase III study of two HPV vaccines in healthy female volunteers aged 15–25. The primary endpoint was to test the noninferiority of Papilloguard (Noyan Pajouhan Biopharma) to Cervarix (GlaxoSmithKline) as measured by the geometric mean titer (GMT) ratios of HPV-16 and HPV-18 7 months after the first vaccination. Secondary endpoints were the proportion of local and systemic solicited and unsolicited events, and the number of females with seroconversion against HPV-16 and HPV-18 7 months after the first vaccination.

Results
Out of 504 screened women, 218 were enrolled. Seven months after the first vaccination, GMT ratios of HPV-16 and HPV-18 were 0.59 and 0.93, respectively. The seroconversion rates of both Papilloguard (Noyan Pajouhan Biopharma) and Cervarix (GlaxoSmithKline) were more than 96%. Both vaccinated groups had a generally good profile of solicited and unsolicited adverse events (AEs). The most common AE was discomfort at the injection site, which was well tolerated.

Conclusion
The result analysis of this study supports the noninferiority of Papilloguard (Noyan Pajouhan Biopharma) to Cervarix (GlaxoSmithKline) in terms of safety and immunogenicity based on the GMT ratio. However, long-term comparative studies to evaluate the sustainability of GMT response and risk of cervical intraepithelial neoplasia grades 2–3 are needed.
Perspectives of Rural Primary Care Clinicians on Pediatric Attention-Deficit/Hyperactivity Disorder Care
Authors: O'Dell Sean M. , Gormley Matthew J. , Schlieder Victoria , Klinger Tracey , DeHart Kathy , Kettlewell Paul W. , Kulchak Rahm Alanna 
Published: March 2022

ABSTRACT:

Objective:
Despite efficacious treatments, evidence-based guidelines, and increased availability of integrated behavioral health care, youth coping with attention-deficit/hyperactivity disorder (ADHD) receive suboptimal care. More research is needed to understand and address care gaps, particularly within rural health systems that face unique challenges. We conducted a qualitative study within a predominantly rural health system with a pediatric-integrated behavioral health care program to address research gaps and prepare for quality improvement initiatives, including primary care clinician (PCC) trainings and clinical decision support tools in the electronic health record (EHR).

Method:
Semistructured interviews were conducted with 26 PCCs representing clinics within the health system. Interview guides were based on the Practical Robust Implementation and Sustainability Model to elicit PCC views regarding determinants of current practices and suggestions to guide quality improvement efforts. We used thematic analysis to identify patterns of responding that were common across participants.

Results:
PCCs identified several internal and external contextual factors as determinants of current practices. Of note, PCCs recommended increased access to continuing education trainings held in clinic over lunch and delivered in less than 30 minutes. Suggested improvements to the EHR included incorporating parent and teacher versions of the Vanderbilt Rating Scale into the EHR, documentation templates aligned with evidence-based guidelines, and alerts and suggestions to aid medication management during appointments.

Conclusion:
Future research to identify implementation strategies to help rural PCCs adopt innovations are needed given the increased responsibility for managing ADHD care and intractable gaps in access to behavioral health care in rural regions.
Inequities in Receipt of the North Carolina Medicaid Waiver Among Individuals with Intellectual Disability or Autism Spectrum Disorder
Authors: Franklin Michelle S. , Bush Christopher , Jones Kelley A. , Davis Naomi Ornstein , French Alexis , Howard Jill , Greiner Melissa A. , Maslow Gary R. 
Published: March 2022

ABSTRACT:

Objective:
We examined characteristics associated with receiving the North Carolina Home and Community-Based Services Waiver for intellectual and developmental disabilities (I/DDs) and its association with emergency department (ED) utilization.

Method:
Through analysis of the North Carolina 2017 to 2018 Medicaid claims and enrollment data, we examined characteristics (age, sex, race and ethnicity, geography, diagnosis (intellectual disability [ID] with or without autism spectrum disorders or autism spectrum disorder without ID) associated with receiving the NC I/DD Waiver and the association of this Wavier with ED utilization. We identified patients with at least 1 International Classification of Diseases-10-CM diagnosis code for an ID or autism spectrum disorder. We excluded patients with missing county information and whose enrollment in the NC I/DD Waiver program began after October 1, 2017.

Results:
Only 22% of 53,531 individuals with I/DD in North Carolina received the Waiver. Non-Hispanic Blacks and Hispanic individuals were less likely to receive the Waiver than non-Hispanic White individuals. Adults (>21 years old), men, and urban residents were more likely to receive the Waiver. Individuals who received the Waiver were 31% less likely to use the ED.

Conclusion:
Innovative strategies are needed to provide equitable access to the NC I/DD Waiver and provide services to the 14,000 people with I/DD currently waiting to receive the Waiver. Through the Waiver, those with I/DD can access preventative and therapeutic outpatient services and decrease their need for ED care. These findings highlight the need for policy reform to address inequities in access to the Waiver for individuals with I/DD.
Comparing Machine Learning to Regression Methods for Mortality Prediction Using Veterans Affairs Electronic Health Record Clinical Data
Authors: Jing Bocheng , Boscardin W. John , Deardorff W. James , Jeon Sun Young , Lee Alexandra K. , Donovan Anne L. , Lee Sei J. 
Published: March 2022

Background:
It is unclear whether machine learning methods yield more accurate electronic health record (EHR) prediction models compared with traditional regression methods.

Objective:
The objective of this study was to compare machine learning and traditional regression models for 10-year mortality prediction using EHR data.

Design:
This was a cohort study.

Setting:
Veterans Affairs (VA) EHR data.

Participants:
Veterans age above 50 with a primary care visit in 2005, divided into separate training and testing cohorts (n= 124,360 each).

Measurements and Analytic Methods:
The primary outcome was 10-year all-cause mortality. We considered 924 potential predictors across a wide range of EHR data elements including demographics (3), vital signs (9), medication classes (399), disease diagnoses (293), laboratory results (71), and health care utilization (149). We compared discrimination (c-statistics), calibration metrics, and diagnostic test characteristics (sensitivity, specificity, and positive and negative predictive values) of machine learning and regression models.

Results:
Our cohort mean age (SD) was 68.2 (10.5), 93.9% were male; 39.4% died within 10 years. Models yielded testing cohort c-statistics between 0.827 and 0.837. Utilizing all 924 predictors, the Gradient Boosting model yielded the highest c-statistic [0.837, 95% confidence interval (CI): 0.835–0.839]. The full (unselected) logistic regression model had the highest c-statistic of regression models (0.833, 95% CI: 0.830–0.835) but showed evidence of overfitting. The discrimination of the stepwise selection logistic model (101 predictors) was similar (0.832, 95% CI: 0.830–0.834) with minimal overfitting. All models were well-calibrated and had similar diagnostic test characteristics.

Limitation:
Our results should be confirmed in non-VA EHRs.

Conclusion:
The differences in c-statistic between the best machine learning model (924-predictor Gradient Boosting) and 101-predictor stepwise logistic models for 10-year mortality prediction were modest, suggesting stepwise regression methods continue to be a reasonable method for VA EHR mortality prediction model development.
Role of Dynamic Parameters of 18F-DOPA PET/CT in Pediatric Gliomas
Authors: Fiz Francesco , Bini Fabiano , Gabriele Edoardo , Bottoni Gianluca , Garrè Maria Luisa , Marinozzi Franco , Milanaccio Claudia , Verrico Antonio , Massollo Michela , Bosio Victoria , Lattuada Marco , Rossi Andrea , Ramaglia Antonia , Puntoni Matteo , Morana Giovanni , Piccardo Arnoldo 
Published: March 2022

Purpose of the Report
PET with 18F-DOPA can be used to evaluate grading and aggressiveness of pediatric cerebral gliomas. However, standard uptake parameters may underperform in circumscribed lesions and in diffuse pontine gliomas. In this study, we tested whether dynamic 18F-DOPA PET could overcome these limitations.

Patients and Methods
Patients with available dynamic 18F-DOPA PET were included retrospectively. Static parameters (tumor/striatum ratio [T/S] and tumor/cortex ratio [T/N]) and dynamic ones, calculated on the tumor time activity curve (TAC), including time-to-peak (TTP), slope steepness, the ratio between tumor and striatum TAC steepness (dynamic slope ratio [DSR]), and TAC shape (accumulation vs plateau), were evaluated as predictors of high/low grading (HG and LG) and of progression-free survival and overall survival.

Results
Fifteen patients were included; T/S, T/N, TTP, TAC slope steepness, and DSR were not significantly different between HG and LG. The accumulation TAC shape was more prevalent in the LG than in the HG group (75% vs 27%). On progression-free survival univariate analysis, TAC accumulation shape predicted longer survival (P < 0.001), whereas T/N and DSR showed borderline significance; on multivariate analyses, only TAC shape was retained (P < 0.01, Harrell C index, 0.93–0.95). On overall survival univariate analysis, T/N (P < 0.05), DSR (P < 0.05), and TAC “accumulating” shape predicted survival (P < 0.001); once more, only this last parameter was retained in the multivariate models (P < 0.05, Harrell C index, 0.86–0.89).

Conclusions
Dynamic 18F-DOPA PET analysis outperforms the static parameter evaluation in grading assessment and survival prediction. Evaluation of the curve shape is a simple-to-use parameter with strong predictive power.
Impact of the Russian invasion of Ukraine on the COVID-19 pandemic dynamics
Authors: Nesteruk Igor 
Published: March 2022

ABSTRACTFull-scale invasion of Ukraine by Russian troops, which began on February 24, 2022, caused an unprecedented number of refugees, which in the ongoing COVID-19 pandemic could increase the number of patients. The recent pandemic dynamics in Ukraine, Poland, Germany and in the whole world was compared with the previous epidemic waves simulated with the use of the generalized SIR-model and corresponding parameter identification procedure. Since before the war the estimation of the number of infectious persons per capita in Ukraine 3.6 times exceeded the global figure, the increase of the number the new cases and the pandemic duration is expected. From the beginning of March 2022 the increase of the averaged number of new cases in Germany and worldwide is visible.
Molecular Control of Circuit Plasticity and the Permanence of Imprinted Odor Memory
Authors: Wu Yunming , Ma Limei , Qiu Qiang , Xu Wenjing , Misra Aviral , Duyck Kyle , Blanck Jillian , Scott Allison R. , Chen Shiyuan , Hassan Huzaifa , Corbin Timothy J. , Moran Andrea , Hall Kate , Li Hua , Perera Anoja , Yu C. Ron 
Published: March 2022

AbstractBehavioral imprinting is a distinct form of learning that has a lifelong impact on social interactions and affectional behaviors1-4. Unlike other forms of memory, imprinting does not require conspicuous association of stimuli; exposure per se appears sufficient to induce memories that neither undergo extinction nor are altered by experience later in life. The site of storage of imprinted memory and the mechanisms that control its formation and permanence are unknown. Here we uncover a molecular mechanism that controls olfactory imprinting, which underlies behaviors including kin and nest recognition, maternal attachment, and homing5-10. We show that odor exposure during the perinatal period converts an innately aversive odor into a homing signal. The behavioral change is associated with odor-induced changes in the projection patterns of olfactory sensory neuron (OSN) expressing the cognate receptors for the exposed odor. We show that the Wnt signaling receptor Frizzled1 (Fzd1) acts as a master regulator of the critical period of OSN development and is responsible for closing the critical period to prevent further changes in the neural circuit. In Fzd1 knockout mice axon projection patterns are continually modified by sensory experience. As Fzd1 knockout abolishes the developmental critical period, it also abolishes odor imprinting. Specific knockout of Fzd1 in the OSNs have the same effect. Mechanistically, Fzd1 controls the critical period through an autoregulated shutdown and by controlling an activity-driven regulon in the OSNs. The transient expression and the subsequent downregulation of Fzd1 leads to the irreversible closure of the critical period to lock in circuits established during the critical period. The evidence suggests that imprinted odor memory is stored in the patterns of connectivity at the first synapse in the olfactory bulb. Early odor experience induces changes in the OSN projection to alter connectivity with innate circuits to establish a life-long memory.
Factors affecting innovative behavior of Vietnamese enterprises employees
Authors: Nguyen Thi Phuong Linh 
Published: March 2022

PurposeThe purpose of this paper is to investigate the factors affecting innovative behavior (IB) of Vietnamese enterprises employees based on theories of transformational leadership, social cognitive and knowledge spiral.Design/methodology/approachThis study used a combination of in-depth interviews and large-scale surveys in 15 enterprises in the North, Central and South of Vietnam. In total, 455 valid questionnaires from employees of information technology, telecommunications and e-commerce enterprises have been used in this research to explore the impact of transformational leadership (TL), coworker support (CS) and organizational learning (OL) on employees' IB. The data collected were subjected to quantitative analysis, including Cronbach's alpha reliability test, exploratory factor analysis (EFA), confirmatory factor analysis (CFA) and structural equation modeling (SEM) for scales and hypotheses testing.FindingsThe results show that there are positive relationships between TL, OL and employees' IB, in which OL has a stronger impact than TL.Research limitations/implicationsThe limitations of this paper are that other factors affecting the innovation behavior of employees in Vietnamese enterprises have not been fully explored, the rejection of the hypothesis about the relationship between CS and employees’ IB needs to be considered with the moderating role of job characteristics and the use of convenient random sample selection, due to which its reliability may not be guaranteed.Practical implicationsFrom the results of this study, the authors point out that managers in Vietnamese enterprises should develop TL to deliver more creativity in an organization and enhance the corporate learning-oriented environment.Originality/valueThis paper contributes to the existing literature by focusing on factors affecting IB of enterprises employees in Vietnam, an emerging economy in the world.
Investigating social factors and their impact on value co-creation in supply chain ecosystems
Authors: Goetz Franziska , Türkmen Ismail , Buck Christoph , Meckl Reinhard 
Published: March 2022

Purpose
As coopetition often characterizes relationships in ecosystems, social factors are particularly important to ensure resilient and reliable relationships, therefore efficient collaboration, and a corresponding outcome. Social factors have so far only been considered as peripheral factors in the ecosystem literature. Thus, this study aims to analyse the current state of literature to provide initial insights into the impact of social factors on value co-creation in supply chain ecosystems.

Design/methodology/approach
A structured literature review was conducted. Eleven articles were identified which explicitly examined social factors in the context of supply chain ecosystems.

Findings
The findings showed that in current research contributions, especially three social factors are considered crucial for value co-creation within supply chain ecosystems: trust, commitment and mindset. Moreover, researchers focus so far only on positive-affected social factors.

Research limitations/implications
The findings enable ecosystem orchestrators as well as actors to strengthen social factors in supply chain ecosystems. The cultivation and proactive consideration of social factors is crucial for efficient and effective collaboration and has a corollary effect on supply chain ecosystems value co-creation.

Originality/value
This paper extends the limited literature on social factors within supply chain ecosystems, notably from a strategic management perspective. The findings help scholars to understand why social factors do play a crucial role regarding the value co-creation in supply chain ecosystem and how specific social factors influence the overall business outcome. By raising awareness of the importance of social factors for all ecosystem actors, complementary cooperation in the ecosystem improves, which in turn has a positive impact on value co-creation.
Personal health budgets: a mechanism to encourage service integration?
Authors: Welch Elizabeth , Jones Karen , Fox Diane , Caiels James 
Published: March 2022

PurposeIntegrated care continues to be a central aim within health and social care policy in England. Personal budgets and personal health budgets aim to place service users at the centre of decision-making and are part of a wider long-term initiative working towards personalised and integrated care. Personal budgets began in social care with the national pilot programme of individual budgets, which aimed to incorporate several funding streams into one budget, but in practice local authorities limited these to social care expenditure. Personal budgets then moved into the health care sector with the introduction of a three-year personal health budgets pilot programme that started in 2009. The purpose of the paper is to explore the post-pilot implementation of personal health budgets and explore their role in facilitating service integration. We examine this through the RE-AIM framework.Design/methodology/approachDuring 2015 and 2016, eight organisational representatives, 23 personal health budget holders and three service providers were interviewed, 42 personal health budget support plans were collected and 14 service providers completed an online survey.FindingsOverall, personal health budgets continued to be viewed positively but progress in implementation was slower than expected. Effective leadership, clear communication and longer-term implementation were seen as vital ingredients in ensuring personal health budgets are fully embedded and contribute to wider service integration.Originality/valueThe paper highlights the importance of policy implementation over the longer-term, while illustrating how the venture of personal health budgets in England could be a mechanism for implementing service integration. The findings can serve to guide future policy initiatives on person-centred care and service integration.
AI-enabled technologies to assist Muslim tourists in Halal-friendly tourism
Authors: Battour Mohamed , Mady Khalid , Salaheldeen Mohamed , Elsotouhy Mohamed , Elbendary Israa , Boğan Erhan 
Published: March 2022

Purpose
This paper aims to present a theoretical account of the connection between artificial intelligence (AI) enabled technologies and Muslim-friendly tourism experiences (MFTX) using the customer experience (CX) theory, reference group theory and theory of tourism consumption systems.

Design/methodology/approach
A model research design is adopted to build a theoretical framework that predicts relationships between constructs. Critical assessment in tourism and AI literature is used to explore AI-enabled technologies in Halal-friendly tourism.

Findings
The findings of this paper have conceptualised the CX theory for Muslim travellers satisfying their religious needs in Halal-friendly tourism by suggesting a new construct called the MFTX. It also offered a theoretical model for using AI-enabled technologies to improve the MFTX.

Originality/value
This study provides a new theoretical model for using AI-enabled technologies to improve the MFTX. This paper is also expected to provide suggestions for tourism operators and service providers to cater to Muslim tourists’ needs using AI technologies.