bluuebunny/crossref_metadata_2025_split huggingface dataset:
ELECTROCHEMICAL, DFT AND MULTISCALE SIMULATION STUDIES ON SELF-ASSEMBLED FILMS OF 2-AMINO-4-METHYL-PYRIDINE INHIBITOR FOR COPPER METAL CORROSION PROTECTION IN 3.5% NaCl MEDIUM
Authors: BALAJI J. , GHOREISHIAMIRI S. , RAJA P. BOTHI , OH T. H. , SETHURAMAN M. G. 
Published: March 2022

Copper metal and its alloys are the most used in the industries because it holds excellent conductivity and natural corrosion protectiveness against air/moisture. However, copper undergoes degradation in presence of aggressive 3.5% NaCl. Protective coating is one of the practical methods to safeguard copper metal. In this study, 2-amino-4-methyl-pyridine (AMP) was coated as self-assembled monolayer method (SAM) with different immersion periods (12 h/24 h) and investigated the corrosion potential against 3.5% NaCl medium. Chemical composition of AMP/SAM/Cu was characterized using Fourier-transform infrared (FT-IR) spectroscopy and morphological analysis using atomic force microscopy (AFM) techniques. AMP’s corrosion inhibition potential were evaluated via electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDS) analyses. Quantum chemical calculations and molecular dynamics (MD) simulations explained the stronger adsorption of AMP over copper metal surface via self-assembly method. The corrosion analysis revealed that AMP’s SAM formation (24 h immersion) enhances the corrosion protection of Cu metal, which is mainly due to the uniform thin adhesive compact layer formation and blocks incoming corrosive chloride ions. EIS investigation evident that AMP forms an adhesive layer over the copper surface and prevents the diffusion of aggressive corrosive medium, while PP studies revealed that AMP acts via the mixed mode of corrosion inhibition mechanism. AMP’s significant inhibition efficiency 90% was confirmed via PP analysis. AFM analysis enabled the morphology image of AMP’s shielding over Cu surface and the molecular modeling investigation supported well for the Cu–N (from AMP) bond formation.
Systematic Evaluation Meta-Analysis of the Efficacy of Recombinant Human Endostatin Combined with Gemcitabine and Cisplatin in Non-Small-Cell Lung Cancer
Authors: Zhang Li , He Yuan , Yi ChengFeng , Huang Mei 
Published: March 2022

Objective. To evaluate the efficacy of recombinant human endostatin combined with gemcitabine and cisplatin in the treatment of non-small-cell lung cancer (NSCLC). Methods. The databases of Cochrane Library, Embase, ClinicalTrials, PubMed, HowNet, Wanfang, and VIP were searched to collect randomized controlled trials (RCTs) of recombinant human endostatin combined with gemcitabine and cisplatin (experimental group) and gemcitabine combined with cisplatin (control group) for comparative study. The quality of literature was evaluated by bias risk assessment tools and related scales, and then meta-analysis was performed. Results. A total of 27 RCTs (1646 patients) were included. The results of meta-analysis showed that the effective rate (

P

< 0.000 01) and benefit rate (

P

< 0.000 01) of the experimental group were significantly higher than those of the control group, the incidence of leucopenia (

P

= 0.79), thrombocytopenia (

P

= 0.39), and gastrointestinal reaction (

P

= 0.85) were not statistically significant. Conclusion. The combination of recombinant human endostatin, gemcitabine, and cisplatin can increase the efficacy and safety of NSCLC patients.
Breast Arterial Calcification: a Novel Cardiovascular Risk Enhancer Among Postmenopausal Women
Authors: Iribarren Carlos , Chandra Malini , Lee Catherine , Sanchez Gabriela , Sam Danny L. , Azamian Farima Faith , Cho Hyo-Min , Ding Huanjun , Wong Nathan D. , Molloi Sabee 
Published: March 2022

Background:
Breast arterial calcification (BAC), a common incidental finding in mammography, has been shown to be associated with angiographic coronary artery disease and cardiovascular disease (CVD) outcomes. We aimed to (1) examine the association of BAC presence and quantity with hard atherosclerotic CVD (ASCVD) and global CVD; (2) ascertain model calibration, discrimination and reclassification of ASCVD risk; (3) assess the joint effect of BAC presence and 10-year pooled cohorts equations risk on ASCVD.

Methods:
A cohort study of 5059 women aged 60-79 years recruited after attending mammography screening between October 2012 and February 2015 was conducted in a large health plan in Northern California, United States. BAC status (presence versus absence) and quantity (calcium mass mg) was determined using digital mammograms. Prespecified end points were incident hard ASCVD and a composite of global CVD.

Results:

Twenty-six percent of women had BAC >0 mg. After a mean (SD) follow-up of 6.5 (1.6) years, we ascertained 155 (3.0%) ASCVD events and 427 (8.4%) global CVD events. In Cox regression adjusted for traditional CVD risk factors, BAC presence was associated with a 1.51 (95% CI, 1.08–2.11;
P
=0.02) increased hazard of ASCVD and a 1.23 (95% CI, 1.002–1.52;
P
=0.04) increased hazard of global CVD. While there was no evidence of dose-response association with ASCVD, a threshold effect was found for global CVD at very high BAC burden (95th percentile when BAC present). BAC status provided additional risk stratification of the pooled cohorts equations risk. We noted improvements in model calibration and reclassification of ASCVD: the overall net reclassification improvement was 0.12 (95% CI, 0.03–0.14;
P
=0.01) and the bias-corrected clinical-net reclassification improvement was 0.11 (95% CI, 0.01–0.22;
P
=0.04) after adding BAC status.

Conclusions:
Our results indicate that BAC has potential utility for primary CVD prevention and, therefore, support the notion that BAC ought to be considered a risk-enhancing factor for ASCVD among postmenopausal women.
Prognostic Role of Pulmonary Function in Patients With Heart Failure With Reduced Ejection Fraction
Authors: Chang Hao‐Chih , Huang Wei‐Ming , Yu Wen‐Chung , Cheng Hao‐Min , Guo Chao‐Yu , Chiang Chern‐En , Chen Chen‐Huan , Sung Shih‐Hsien 
Published: March 2022

Background
Both ventilatory abnormalities and pulmonary hypertension (PH) are frequently observed in patients with heart failure with reduced ejection fraction. We aim to investigate the association between ventilatory abnormalities and PH in heart failure with reduced ejection fraction, as well as their prognostic impacts.

Methods and Results
A total of 440 ambulatory patients (age, 66.2±15.8 years; 77% men) with left ventricular ejection fraction ≤40% who underwent comprehensive echocardiography and spirometry were enrolled. Total lung capacity, forced vital capacity, and forced expiratory volume in the first second were obtained. Pulmonary arterial systolic pressure was estimated. PH was defined as a pulmonary arterial systolic pressure of >50 mm Hg. The primary end point was all‐cause mortality at 5 years. Patients with PH had significantly reduced total lung capacity, forced vital capacity, and forced expiratory volume in the first second. During a median follow‐up of 25.9 months, there were 111 deaths. After accounting for age, sex, body mass index, renal function, smoking, left ventricular ejection fraction, and functional capacity, total lung capacity (hazard ratio [HR] per 1 SD, 0.66; 95% CI per 1 SD, 0.46–0.96), forced vital capacity (HR per 1 SD, 0.64; 95% CI per 1 SD, 0.48–0.84), and forced expiratory volume in the first second (HR per 1 SD, 0.72; 95% CI per 1 SD, 0.53–0.98) were all significantly correlated with mortality in patients without PH. Kaplan‐Meier curve demonstrated impaired pulmonary function, defined as forced expiratory volume in the first second ≤58% of predicted or forced vital capacity ≤65% of predicted, was associated with higher mortality in patients without PH (HR, 2.85; 95% CI, 1.66–4.89), but not in patients with PH (HR, 1.05; 95% CI, 0.61–1.82).

Conclusions
Ventilatory abnormality was more prevalent in patients with heart failure with reduced ejection fraction with PH than those without. However, such ventilatory defects were related to long‐term survival only in patients without PH, regardless of their functional status.
Electrophysiological and behavioral responses of blister beetle Mylabris pustulata to plant volatiles
Authors: Nebapure Suresh , Kumar Sanitya 
Published: March 2022

Abstract
Plant volatiles, constitutive or induced, are perceived by insect pests to locate the host plant and also by natural enemies to locate the host insect. These plant volatiles can be utilized to develop attractive or repellant lures for pest management. Studies were carried out to identify the plant volatiles which are induced in pigeonpea, Cajanus cajan (L.) Huth due to the herbivory of blister beetle, Mylabris pustulata. The volatiles from healthy uninfested pigeonpea plants and blister beetle-infested plants were collected using the dynamic headspace collection method with Porapaq Q (80-100 mesh) as adsorbent. Using gas chromatography-mass spectrometry, 28 compounds were identified from uninfested pigeonpea plants whereas 16 compounds were identified from infested plants. A qualitative analysis showed that α-pinene and 3-hexen-2-one were exclusively detected in infested plants and (Z)-3-hexen-1-yl acetate and acetophenone were released in higher quantities from infested plants than from uninfested one. Electrophysiological evaluation of these volatiles along with other plant volatiles showed that blister beetle antennae eliciting higher responses to eucalyptol at a 1-μg dose, to nerol at a 10-μg dose and to benzyl acetate at 100- and 1000-μg doses. Beetle traps with lures of eucalyptol, benzaldehyde, benzyl acetate, and nerol attracted a very small number of blister beetle adults, suggesting the need for further efforts to standardize lure load and trap design.
Effect of seawater aging on impact behavior of glass fiber/epoxy laminates with drilled holes
Authors: Rubio-González Carlos , Hernández-Santos Maximiliano , José-Trujillo Eduardo , Rodríguez-González Julio Alejandro 
Published: March 2022

During their service life, composite marine structures made up of glass fiber reinforced polymers are susceptible to be affected by environmental and loading conditions such as seawater and low velocity impacts which can cause them severe structural damage. Based on this fact and concern, the present work investigates the influence of seawater aging on impact behavior of glass fiber/epoxy composite laminates with and without drilled holes. To achieve this goal, glass fiber/epoxy laminates were manufactured by resin transfer molding and then cut into specimens for low velocity impact testing. Before impact tests, specimens were immersed in artificial seawater at 70°C for 1464 h. After that time, dry (before seawater aging) and wet (after seawater aging) specimens were tested at 10 and 15 J impact energies using a drop-weight impact tower. The results of accelerated seawater aging confirmed that the presence of drilled holes in composites does not influence on their moisture absorption content and diffusion coefficient. The impact test results showed that the impact properties of wet specimens are significantly lower respect to dry specimens. It was found that the peak force of wet specimens displays a reduction of approximately 40% with respect to the dry specimens as a consequence of moisture absorption which causes plasticization of the polymeric matrix. Ultrasonic C-scan inspection showed that damage area of wet specimen increased up to 250% compared to that of dry specimen. Fractographic analyses by scanning electron microscopy and X-ray computerized tomography revealed that low velocity impact in composite laminates produced damage mechanisms associated to matrix cracking, fiber/matrix debonding, fiber breakage, and delamination, which were more prominent in laminates with drilled holes and subjected to a previous seawater exposition.
Advances in Artificial Intelligence to Diagnose Otitis Media: State of the Art Review
Authors: Ngombu Stephany , Binol Hamidullah , Gurcan Metin N. , Moberly Aaron C. 
Published: March 2022

AbstractObjectiveOtitis media (OM) is a model disease for developing, validating, and implementing artificial intelligence (AI) techniques. We aim to review the state of the art applications of AI used to diagnose OM in pediatric and adult populations.Data SourcesSeveral comprehensive databases were searched to identify all articles that applied AI technologies to diagnose OM.Review MethodsRelevant articles from January 2010 through May 2021 were identified by title and abstract. Articles were excluded if they did not discuss AI in conjunction with diagnosing OM. References of included studies and relevant review articles were cross‐referenced to identify any additional studies.ConclusionTitle and abstract screening resulted in full‐text retrieval of 40 articles that met initial screening parameters. Of this total, secondary review articles (n = 7) and commentary‐based articles (n = 2) were removed, as were articles that did not specifically discuss AI and OM diagnosis (n = 5), leaving 25 articles for review. Applications of AI technologies specific to diagnosing OM included machine learning and natural language processing (n = 23) and prototype approaches (n = 2).Implications for PracticeThis review emphasizes the utility of AI techniques to automate and aid in diagnosing OM. Although these techniques are still in the development and testing stages, AI has the potential to improve the practice of otolaryngologists and primary care clinicians by increasing the efficiency and accuracy of diagnoses.
Postoperative and 1‐Year Functional Outcomes After Free Flap Surgery Among Patients 80 Years or Older
Authors: Davis Kyle P. , Kompelli Anvesh , Gardner James Reed , Mohler Samantha , Gammill Sarah , King Deanne , Vural Emre , Sunde Jumin , Moreno Mauricio Alejandro 
Published: March 2022

ObjectiveTo evaluate the postoperative and 1‐year functional outcomes after free flap surgery among patients ≥80 years old.Study DesignRetrospective chart review.SettingSingle tertiary care center.MethodsWe conducted a retrospective review of 596 patients who underwent head and neck ablation and reconstruction with free tissue over a 7‐year period. Patients ≥80 years of age were included.ResultsFifty patients were ≥80 years old, with an average age of 83.7 years. Ninety‐day mortality was 12.0%, and those who died were of older age (87.5 vs 83.1 years, P =. 036). Prior radiation therapy (odds ratio, 6.8 [95% CI, 1.1‐42.7]) and a Charlson Comorbidity Index ≥3 (odds ratio, 10.0 [95% CI, 1.5‐67.0]) were associated with an increased risk of 90‐day mortality. Overall 21 (42.0%) patients experienced a 30‐day complication; 7 (14.0%) were readmitted within 30 days; and 5 (10.0%) underwent additional flap‐related operations. Flap failure occurred in 2 (4.0%) patients. Before surgery, 45 (90%) patients were living independently or within assisted living; among these, 19.5% declined to dependent functional status at 90‐day follow‐up. At 90 days, 2 (8.3%) of 24 patients remained tracheostomy dependent, and 20 (66.7%) of 30 patients required feeding tube supplementation. Among 42 patients, 36 (85.7%) had unrestricted or modified oral diets at 90 days. Charlson Comorbidity Index ≥2 was associated with an increased risk of 1‐year mortality (odds ratio, 5.1 [95% CI, 1.4‐18.6]).ConclusionThe potential for functional decline and risk of 90‐day mortality should be discussed with patients aged ≥80 years.
Civic engagement in serious illness, death, and loss: A systematic mixed-methods review
Authors: D’Eer Louise , Quintiens Bert , Van den Block Lieve , Dury Sarah , Deliens Luc , Chambaere Kenneth , Smets Tinne , Cohen Joachim 
Published: March 2022

Background: New public health approaches to palliative care such as compassionate communities aim to increase capacity in serious illness, death, and loss by involving civic society. Civic engagement has been described in many domains of health; a description of the characteristics, processes, and impact of the initiatives in palliative care is lacking. Aim: To systematically describe and compare civic engagement initiatives in palliative care in terms of context, development, impact, and evaluation methods. Design: Systematic, mixed-methods review using a convergent integrated synthesis approach. Registered in Prospero: CRD42020180688. Data sources: Six databases (PubMed, Scopus, Sociological Abstracts, WOS, Embase, PsycINFO) were searched up to November 2021 for publications in English describing civic engagement in serious illness, death, and loss. Additional grey literature was obtained by contacting the first authors. We performed a quality appraisal of the included studies. Results: We included 23 peer-reviewed and 11 grey literature publications, reporting on nineteen unique civic engagement initiatives, mostly in countries with English as one of the official languages. Initiatives involved the community in their development, often through a community-academic partnership. Activities aimed to connect people with palliative care needs to individuals or resources in the community. There was a variety of evaluation aims, methods, outcomes, and strength of evidence. Information on whether or how to sustain the initiatives was generally lacking. Conclusions: This is the first review to systematically describe and compare reported civic engagement initiatives in the domain of palliative care. Future studies would benefit from improved evaluation of impact and sustainability.
Cerebrovascular responses to somatomotor stimulation in Parkinson’s disease: A multivariate analysis
Authors: Barnes Sam C , Panerai Ronney B , Beishon Lucy , Hanby Martha , Robinson Thompson G , Haunton Victoria J 
Published: March 2022

Parkinson’s disease (PD) is a common neurodegenerative disorder, yet little is known about cerebral haemodynamics in this patient population. Previous studies assessing dynamic cerebral autoregulation (dCA), neurovascular coupling (NVC) and vasomotor reactivity (VMR) have yielded conflicting findings. By using multi-variate modelling, we aimed to determine whether cerebral blood flow (CBF) regulation is impaired in PD patients. 55 healthy controls (HC) and 49 PD patients were recruited. PD subjects underwent a second recording following a period of abstinence from their anti-Parkinsonian medication. Continuous bilateral transcranial Doppler in the middle cerebral arteries, beat-to-beat mean arterial blood pressure (MAP; Finapres), heart rate (HR; electrocardiogram), and end-tidal CO2 (EtCO2; capnography) were measured. After a 5-min baseline period, a passive motor paradigm comprising 60 s of elbow flexion was performed. Multi-variate modelling quantified the contributions of MAP, ETCO2 and neural stimulation to changes in CBF velocity (CBFV). dCA, VMR and NVC were quantified to assess the integrity of CBF regulation. Neural stimulation was the dominant input. dCA, NVC and VMR were all found to be impaired in the PD population relative to HC (p < 0.01, p = 0.04, p < 0.01, respectively). Our data suggest PD may be associated with depressed CBF regulation. This warrants further assessment using different neural stimuli.
Circumferential Rim Augmentation Suture Around the Perimeniscal Capsule Decreases Meniscal Extrusion and Progression of Osteoarthritis in Rabbit Meniscus Root Tear Model
Authors: Park Do Young , Yin Xiang Yun , Chung Jun Young , Jin Yong Jun , Kwon Hyeon Jae , Lee Ga bin , Park Jin Ho , Min Byoung-Hyun 
Published: March 2022

Background: We recently analyzed the joint capsule adjacent to the medial meniscus and found that the perimeniscal joint capsule has collagen fiber orientation similar to that of circumferential meniscal fibers, potentially playing a role in preventing extrusion. Purpose: To analyze the meniscal extrusion prevention potential of the circumferential rim augmentation suture around the perimeniscal capsule in a rabbit root tear model and analyze the biomechanical function in a porcine cadaveric knee. Study Design: Controlled laboratory study. Methods: Rabbit medial meniscus root tear models were divided into 3 experimental groups: root tear, root tear and suture repair, and root tear and circumferential rim augmentation suture. As for the circumferential rim augmentation suture procedure, a suture was placed to circumscribe the outer rim of the medial meniscus and passed through bone tunnels located at the tibial insertion of each root. After 4 and 8 weeks, meniscal extrusion was analyzed by micro–computed tomography, gross morphology, and histologic analysis of the medial femoral cartilage. For biomechanical analysis, porcine knees were divided into groups similar to rabbit experiments. Tibiofemoral contact parameters were assessed using a pressure mapping sensor system after applying a load of 200 N on the knee joint. Results: The root tear and circumferential rim augmentation suture group showed less meniscal extrusion, less gap within the tear site, and less cartilage degeneration compared with other groups after 4 and 8 weeks of surgery in the rabbit root tear model. Biomechanical analysis showed the root tear and circumferential rim augmentation suture group had larger contact area and lower peak contact pressure compared with root tear and root tear and suture repair groups. Conclusion: The circumferential rim augmentation suture reduced the degree of meniscal extrusion while restoring meniscal function, potentially preventing progression of arthritis in a rabbit root tear model and porcine knee biomechanical analysis. Clinical Relevance: The circumferential rim augmentation suture may be a novel augmentation option during root tear treatment.
Bone Marrow Aspirate Concentrate Is Equivalent to Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis at 2 Years: A Prospective Randomized Trial
Authors: Anz Adam W. , Plummer Hillary A. , Cohen Achraf , Everts Peter A. , Andrews James R. , Hackel Joshua G. 
Published: March 2022

Background: Autologous platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMC) are being used clinically as therapeutic agents for the treatment of knee osteoarthritis. Purpose/Hypothesis: The purpose of this study was to compare the efficacy of BMC and PRP on pain and function in patients with knee osteoarthritis up to 24 months after injection. It was hypothesized that patients receiving BMC would have better sustained outcomes than those receiving PRP. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: A total of 90 participants aged between 18 and 80 years with symptomatic knee osteoarthritis (Kellgren-Lawrence grades 1-3) were randomized into 2 study groups: PRP and BMC. Both groups completed the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and subjective International Knee Documentation Committee (IKDC) questionnaire before and 1, 3, 6, 9, 12, 18, and 24 months after a single intra-articular injection of leukocyte-rich PRP or BMC. A linear mixed-effects model was performed to quantify the effects over time and the difference between the groups. This model has the random effect for time to assess the extent in which the change over time differs from one person to another. Results: An overall 84 patients completed questionnaires from baseline to 12 months; however, 17 patients (n = 9; PRP group) were lost to follow-up at 18 months and 25 (n = 13; PRP group) at 24 months. There were no statistically significant differences in IKDC ( P = .909; 95% CI, −6.26 to 7.03) or WOMAC ( P = .789; 95% CI, −6.26 to 4.77) scores over time between the groups. Both groups had significantly improved IKDC ( P < .001; 95% CI, 0.275-0.596) and WOMAC ( P = .001; 95% CI, −0.41 to −0.13) scores from baseline to 24 months after the injection. These improvements plateaued at 3 months and were sustained for 24 months after the injection, with no difference between PRP and BMC at any time point. Conclusions: For the treatment of osteoarthritis, PRP and BMC performed similarly out to 24 months. BMC was not superior to PRP. Registration: NCT03289416 (ClincalTrials.gov identifier).