bluuebunny/crossref_metadata_2025_split huggingface dataset:
How effective are treatment guidelines for augmented RLS?
Authors: Yeung Laiwah Jonathan , Winkelman John W 
Published: May 2022

Abstract

Study Objectives
The objective of this study was to assess the effectiveness of current treatment guidelines for restless legs syndrome (RLS) augmentation in patients on dopamine agonists (DAs) which recommend a cross-titration strategy to an alpha-2-delta ligand (A2D) and/or opioid.

Methods
Consecutive new consultations for RLS with both augmentation and active treatment with DAs at the time of initial assessment were included if followed &gt;5 months. Clinical information from the semi-structured initial consultation, and subsequent visits until their most recent/final visit was extracted. Clinical Global Impression-Severity (CGI-S) and Clinical Global Impression-Improvement (CGI-I) scores were retrospectively determined by two independent evaluators.

Results
In the 63 patients with augmented RLS on DAs, followed for 5–59 months (mean = 28, SD = 14), the average age was 67.6 (SD = 9.8) and 63% were female. Mean duration of prior dopaminergic therapy was 11.6 years (SD = 6.7) and average pramipexole equivalent dose was 1.23 mg (SD = 1.22 mg). At baseline, RLS was “moderate-markedly” severe (CGI-S = 4.9). At the final/most recent visit, 78% (49/63) were classified as Responders (CGI-I ≤ 2, “Much” or “Very Much Improved”) with an average CGI-S of 2.4 (“borderline-mildly ill”). Responders (59%) were more likely to have discontinued DAs than Non-Responders (40%), and mean opioid doses were higher in Responders (39 vs 20 MME). No differences in baseline DA dose, final A2D dose, or iron therapy were observed between groups. Responders did have significantly more severe RLS, more sleep maintenance insomnia, and greater subjective daytime sleepiness at baseline (p &lt; 0.05).

Conclusions
Guideline-based management is effective in most patients with augmented RLS on DAs.
Crossbreeding beef sires to dairy cows: cow, feedlot, and carcass performance
Authors: Foraker Blake A , Ballou Michael A , Woerner Dale R 
Published: May 2022

Abstract
Genetic and reproductive advancements in the dairy industry, volatile milk markets, and beef packer restrictions on dairy carcasses have increased the popularity of crossbreeding beef sires to dairy cows in the United States. This observational study aimed to understand performance of dairy cows bred to beef sires and feedlot and carcass performance of crossbred beef × dairy cattle. For dairy cow performance, archived records from two dairies representing two successive lactations were evaluated in cows (Dairy A: n = 72/group; Dairy B: n = 456/group) representing 1) All Dairy, where previous sire type of conception was Holstein for both lactations, or 2) Beef on Dairy, where previous sire type of conception was Holstein for the preceding lactation and a beef breed for the subsequent lactation. For feedlot performance, closeout data from pens (n = 26/cattle type) of beef and beef × dairy steers and heifers were evaluated. For carcass performance, individual carcass data were compared between conventional beef (n = 966), beef × dairy (n = 518), and Holstein (n = 935) steers sampled across a variety of processing facilities, harvest lots, and geographical regions. Cow lactation performance was minimally impacted by sire type of previous conception. Cows conceived to beef sires exhibited a 2 to 3 d greater (P &lt; 0.01) gestation length than cows conceived to Holstein sires. Beef × dairy cattle were not largely different in weight gain at the feedlot but exhibited 1-unit lesser (P &lt; 0.01) dressing percentage than beef cattle. Beef × dairy carcasses possessed 18% lesser (P &lt; 0.05) 12th rib fat thickness than beef cattle and 5% greater (P&lt; 0.05) ribeye area than dairy cattle. Additionally, beef cattle produced nearly double (P &lt; 0.05) the percentage of yield grade 4 carcasses produced by beef × dairy and Holstein cattle.
Evaluating the impact of feeding dried distillers grains with solubles on Boer goat growth performance, meat color stability, and antioxidant capacity
Authors: Dahmer Payton L , McDonald Faith B , Chun Colin K Y , Zumbaugh Charles A , Jones Cassandra K , Crane Alison R , Kott Tamra , Lattimer James M , Chao Michael D 
Published: May 2022

AbstractA total of 72 male Boer goat kids (21.7 ± 0.5 kg) were fed for 21 d with 3 kids per pen and 12 pens per treatment. Dietary treatments were: 0% inclusion of dried distillers grains with solubles (DDGS; 0% DDGS) or 33% DDGS inclusion (33% DDGS) and were provided ad libitum. Goats and feeders were weighed weekly to collect body weights (BW) and determine feed disappearance in order to calculate average daily gain (ADG), average daily feed intake (ADFI), and feed efficiency (G:F). At the conclusion of the feeding study, a subset (n = 30; 2–3 goats from each pen representing six6 pens per treatment) of goats were harvested, carcasses evaluated, and loins were fabricated into 2.54 cm chops. Goat chop discoloration was evaluated by trained panelists and measured for L*, a*, and b* values on days 0, 4, 7, and 10 under retail display conditions. Samples were collected and analyzed for lipid oxidation, fatty acid profile, and hydrophilic and lipophilic antioxidant capacity. No evidence of differences was observed for final BW, ADFI, G:F, and carcass characteristics (P &gt; 0.05). However, goats fed the 0% DDGS diet had greater ADG compared with those fed a diet containing 33% DDGS (P = 0.05). Overall, visual evaluation of discoloration, L*, a*, and b* as well as lipid oxidation data confirmed that feeding 33% DDGS to goats had no effect on goat chop discoloration and lipid oxidation (P &gt; 0.10). However, all chops demonstrated a display effect, which they increased in visual discoloration and lipid oxidation and decreased in a* and b* values (P &lt; 0.01) over the entirety of the 10-d period of retail display, regardless of the dietary treatments. As expected, feeding 33% DDGS to goats decreased relative percentage of multiple and total monounsaturated fatty acids, but increased relative percentage of multiple and total polyunsaturated fatty acids (PUFA; P &lt; 0.05). The antioxidant capacity measurements showed no treatment difference in the hydrophilic portion (P &gt; 0.10), but chops from the 33% DDGS treatment had greater lipophilic antioxidant activity compared with the 0% DDGS chops (P &lt; 0.05). In conclusion, including 33% DDGS to the diet may negatively impact goat growth performance, but did not impact any carcass characteristics. Feeding a diet with 33% DDGS resulted in an increase in the PUFA content of goat chops but did not appear to impact meat color or lipid oxidation. The supposed negative consequence from increased PUFA is likely counterbalanced by the increased antioxidant capacity in the lipid component of meat, resulting in no difference in meat shelf-life.
Storytelling
Authors: Cadenhead Virginia H. 
Published: May 2022

ABSTRACT:
This state of the science review synthesizes the current literature and theoretical background of storytelling as a health communication tool for oral learners. Storytelling is globally applicable in a variety of settings and formats. Cultural considerations are important. Both theoretical and biblical examples explain how storytelling can influence knowledge, behaviors, attitudes, and outcomes. Although further research is needed, evidence indicates storytelling is an effective tool that nurses can use to fulfill their essential duty of health teaching.
Physical Exercise Modalities for the Management of Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-Analysis
Authors: Guo Yuan , Xiao Changhu , Zhao Kaixuan , He Ziyu , Liu Sha , Wu Xuemei , Shi Shuting , Chen Zhu , Shi Ruizheng 
Published: May 2022

Abstract:
Different physical exercise modalities have been widely studied in patients having heart failure with preserved ejection fraction (HFpEF) but with variably reported findings. We, therefore, conducted a systematic review and meta-analysis to evaluate whether the efficacy of physical activity in the management of HFpEF is related to exercise modalities. PubMed and Embase were searched up to July 2021. The eligible studies included randomized controlled trials that identified effects of physical exercise on patients with HFpEF. Sixteen studies were included to evaluate the efficiency of physical exercise in HFpEF. A pooled analysis showed that exercise training significantly improved peak oxygen uptake (VO2), ventilatory anaerobic threshold, distance covered in the 6-minute walking test, the ratio of early diastolic mitral inflow to annular velocities, the Short Form 36 physical component score, and the Minnesota Living with Heart Failure Questionnaire total score. However, the changes in other echocardiographic parameters including the ratio of peak early to late diastolic mitral inflow velocities, early diastolic mitral annular velocity, and left atrial volume index were not significant. Both high-intensity and moderate-intensity training significantly improved exercise capacity (as defined by peak VO2), with moderate-intensity exercise having a superior effect. Furthermore, exercise-induced improvement in peak VO2 was partially correlated with exercise duration. Physical exercise could substantially improve exercise capacity, quality of life, and some indicators of cardiac diastolic function in patients with HFpEF. A protocol of moderate-intensity exercise training lasting a longer duration might be more beneficial compared with high-intensity training for patients with HFpEF.
Intensive Physical Activity Increases the Risk of Knee and Hip Arthroplasty: A Systematic Review
Authors: Migliorini Filippo , Pintore Andrea , Torsiello Ernesto , Oliva Francesco , Spiezia Filippo , Maffulli Nicola 
Published: May 2022

Purpose:
The present study investigated the type of sport and activity level of athletes before they underwent knee and/or hip arthroplasty for osteoarthritis (OA), and compared them with a control group of subjects who did not undergo knee and hip arthroplasty. We hypothesed athletes exposed to high physical loads during sports had the highest risk of developing OA requiring arthroplasty.

Materials and Methods:
This systematic review was conducted according to the PRISMA guidelines. All the comparative clinical trials to August 2021 investigating the sport activity level between subjects who underwent arthroplasty versus those who did not undergo arthroplasty for OA were considered.

Results:
Data from 5 studies and 3638 patients were collected. The mean age for both groups was 47.61±15.5 years, and the mean body mass index was 24.6±2.1 kg/m2 17.6% were women. The Newcastle-Ottawa scale attested good quality of the methodology of the investigations included in the present study.

Conclusion:
Intense physical exercise, implying a high cumulative number of hours of exercise which can lead to excessive joint overload, in both sexes is associated with greater likelihood of early knee and hip OA which may lead to prosthetic surgery. Moderate and recreational exposure to sport has minor degenerative effects, and is not associated with early onset OA requiring arthroplasty.
The Influence of Athletes’ Age in the Onset of Osteoarthritis: A Systematic Review
Authors: Migliorini Filippo , Vecchio Gianluca , Pintore Andrea , Oliva Francesco , Maffulli Nicola 
Published: May 2022

Purpose:
Whether sport participation is a risk factor for osteoarthritis (OA) development or progression is controversial. Mechanical overload, injuries, genetics, and acquired disorders concur to the onset of OA, with high variability between sports and participants. This study investigated the association between participation in specific sports and the risk of developing knee and hip OA in athletes at different ages. We hypothesized that young athletes who are exposed to high levels of physical activities have a greater risk of developing OA.

Materials and Methods:
This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Google scholar, EMABSE, and Web of Science were accessed in October 2021. No time constrains were used for the search. All the published clinical studies reporting data about relationship between physical activity, OA, and age were included.

Results:
The Newcastle-Ottawa Scale resulted in a final score ≥7 for all studies, attesting good quality of the methodological assessment. Data from 27,364 patients were retrieved. The mean age was 48.2±16.7 years. In all, 21.8% were women.

Conclusions:
Our systematic review suggests an association between high levels of physical activities and knee and hip OA in men younger than 50 years. People who practice intense physical activity, such as professional athletes or heavy workers, are more prone to develop early-onset OA.
Incorporating Patient Safety and Quality Into the Medical School Curriculum: An Assessment of Student Gains
Authors: Ahmed Fasih Ali , Asif Fozia , Mubashir Ayesha , Aboumatar Hanan J. , Hameed Malika , Haider Adil , Latif Asad 
Published: May 2022

Background
Global efforts are being made to improve health care standards and the quality of care provided. It has been shown through research that the introduction of patient safety (PS) and quality improvement (QI) concepts in the medical curriculum prepares medical students to face future challenges in their professional careers.

Purpose
This study aimed to evaluate how a brief course on QI and PS affects the knowledge, efficacy, and system thinking of medical students.

Methods
A 5-day QI and PS intervention course was implemented at the Aga Khan University medical college for 98 third-year medical students in March 2021. This weeklong course of lectures, interactive sessions, and hands-on skill workshops was conducted before the students began their clinical rotations. Students’ knowledge, self-efficacy, and system thinking were assessed with pretest and posttest. Students were also asked to write personal reflections and fill out a satisfaction survey at the end of the intervention.

Results
Comparisons of pretest and posttest scores showed that the course significantly improved students’ knowledge by a mean of 2.92 points (95% confidence interval, 2.30–3.53; P < 0.001) and system thinking by 0.16 points (95% confidence interval, 0.03–0.29; P = 0.018) of the maximum scores of 20 and 5 points, respectively. The students’ self-assessment of PS knowledge also reflected statistically significant increases in all 9 domains (P < 0.001). Students reported positive experiences with this course in their personal reflections.

Conclusions
The medical students exhibited increases in knowledge, self-efficacy, and system thinking after this weeklong intervention. The design of the course can be modified as needed and implemented at other institutions in low- and middle-income countries. A targeted long-term assessment of knowledge and attitudes is needed to fully evaluate the impact of this course.
Delays in Diagnosis, Treatment, and Surgery: Root Causes, Actions Taken, and Recommendations for Healthcare Improvement
Authors: Politi Ruth E. , Mills Peter D. , Zubkoff Lisa , Neily Julia 
Published: May 2022

Objectives
Although patient safety continues to be a priority in the U.S. healthcare system, delays in diagnosis, treatment, or surgery still led to adverse events for patients. The purpose of this study was to review root cause analysis (RCA) reports in the Veterans Health Administration to identify the root causes and contributing factors of delays in diagnosis, treatment, or surgery in an effort to prevent avoidable delays in future care.

Methods
The RCA reports from Veterans Health Administration hospitals from October 2016 through September 2019 were reviewed and the root causes and contributory factors were identified. These elements were coded by consensus and analyzed using descriptive statistics.

Results
During the 3-year study period, 206 RCAs were identified and 163 were analyzed that were specific to delays in diagnosis, treatment, and surgery. The reports identified 24 delays in diagnosis, 117 delays in treatment, and 22 delays in surgery. Delays occurred most often in outpatient settings.

Conclusions
Results supported the need for standardization of care processes and procedures, improved communication between and within department personnel, and improved policies and procedures that will be followed as intended. By reviewing adverse events, root causes, and contributing factors identified by local RCA teams, strategies can be developed to reduce delays in diagnosis and treatment of patients and lead to safer care.
Invited to the party but not allowed to dance? Examining strategic decision-making inclusion of top female executives
Authors: Mooney Ann 
Published: May 2022

PurposeThe gender diversity of top management teams (TMTs) is slowly increasing. Research shows that top executives influence firms through their role in strategic decision-making but that executives are not equally engaged in it. The purpose of this paper is to understand whether gender affects the likelihood of inclusion in strategic decision-making.Design/methodology/approachDrawing on surveys completed by chief executive officers (CEOs) and using expectation states and gender roles theories, the author examines the relationship between gender and inclusion in strategic decision-making for 266 top executives of global public firms.FindingsAfter controlling for a myriad of factors, results indicate that female executives are less likely than male executives to be included in strategic decision-making. Firm tenure moderates this effect such that it leads to a greater likelihood of inclusion for female executives but not male executives.Originality/valueThis study provides a unique consideration of strategic decision-making in TMTs. The findings suggest that diversity and inclusion do not always go hand in hand and that female executives may need to prove themselves more than male executives to be given an equal voice in the strategic direction of the firm.
Innovating the supply chain in health-related crises: some evidence from ISINNOVA case
Authors: Tani Mario , Troise Ciro , De Bernardi Paola , Han Tian 
Published: May 2022

PurposeAdditive manufacturing (AM) technologies, also known as three-dimensional printing (3DP), is a technological breakthrough that have the potential to disrupt the traditional operations of supply chains. They open the way to a supply chains innovation that can significantly benefit hospitals and health-related organizations in dealing with crises or unexpected events in a faster and more flexible way. In this study the authors identify the boundary of this potential support.Design/methodology/approachThe authors adopt a case study approach to understand the dynamics behind a well-known best practice to identify the main opportunities and the main pitfalls that AM may pose to health-related organizations wanting to leverage them.FindingsThe case highlights that it is possible to increase hospital flexibility using AM and that by leveraging the Internet it is possible to spread the benefits faster than what it would be normally possible using traditional supply chain processes. At the same time the case highlights that leveraging these technologies needs buy-in from all the relevant stakeholders.Originality/valueThe paper is one of the first, to the best of the authors' knowledge, to highlight the main opportunities and difficulties of implementing 3DP technologies in hospital supply chain management.
Creating customer loyalty through global engagement: the role of university social responsibility
Authors: Nguyen Thi Khanh Chi , Nguyen That Huu 
Published: May 2022

PurposeThis study aims to examine how university social responsibility (USR) global engagement is influenced, and its impact on service quality and “customer” loyalty. There are four determinants of USR global engagement which are responsible education programs, knowledge management, organizational management and social engagement.Design/methodology/approachThe data were collected through a structured questionnaire survey conducted in five universities in Vietnam. The dataset consists of 446 valid responses by Vietnamese students. Correlation analysis and structural equation modeling (SEM) were used to test the proposed relationships. Confirmatory factor analysis (CFA) is conducted to verify the reliability and validity of each latent construct, and to evaluate the discriminant validity, convergent validity, composition reliability and average variance extracted (AVE) for the latent constructs.FindingsThis study finds statistically significant and positive effects of responsible education programs, knowledge management, organizational management and social engagement on USR global engagement. The results also reveal the interrelationships among USR global engagement, service quality and loyalty.Practical implicationsFirstly, universities need to facilitate the involvement of all their stakeholders when they adopt USR engagement with the world. Second, universities should seek funders in society, or funders from the trade agreement between their countries and foreign ones to invest in research projects. Third, with the IT development, universities have to explore technological innovation in their teaching and training. Fourth, universities have to reform their mission and strategy to implement USR global engagement as a central pillar.Originality/valueThis study has some contributions to the scarce literature on USR. This study highlights that universities in developing countries like Vietnam need to make a large effort to enhance their teaching and training systems in order to meet the global education standard. The second highlight lies in developing research projects on discovery, methodologies, interpretation and orientation. Further, universities need to address the requirement for more internal communication with students and more external communication with society. Finally, this study found that USR global engagement make customers (students, students' families, businesses, and other stakeholders) trust and become loyal to universities.