bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distal femoral osteotomy versus lateral unicompartmental arthroplasty for isolated lateral tibiofemoral osteoarthritis with intra-articular and extra-articular deformity: a propensity score-matched analysis
Authors: Piovan Gianluca , Farinelli Luca , Screpis Daniele , Iacono Venanzio , Povegliano Lorenzo , Bonomo Marco , Auregli Ludovica , Zorzi Claudio 
Published: July 2022

Abstract
Purpose
Lateral unicompartmental arthroplasty (UKA) and distal femoral osteotomy (DFO) represent surgical solutions in cases of valgus malalignment and isolated lateral osteoarthritis (OA) of the knee. The aim of the present study was to assess the clinical results, complications, and the overall postoperative alignment of a series of DFO and lateral UKA with a minimum 2-year follow-up in active middle-aged patients.

Methods
Patients with valgus knee and isolated lateral OA who underwent opening-wedge DFO or UKA from 2017 to 2019 were reviewed. Each patient was characterized by a joint line convergence angle (JLCA) > 3° and mechanical lateral distal femoral angle (mLDFA) < 87°. We excluded patients who underwent meniscus or osteochondral allograft during DFO. The Oxford Knee Score (OKS), Knee Injury and Osteoarthritis Outcome Score (KOOS), complications, and postoperative alignment were assessed. Propensity score matching was used to identify comparable patients.

Results
The DFO and lateral UKA groups consisted of 29 patients each. No statistically significant differences in gender, age, body mass index (BMI), length of follow-up, or limb deformity were reported between the two groups. In the DFO group, OKS was reported to improve from 27.51 to 38.59 (p < 0.05) and KOOS from 51.14 to 67.2 (p < 0.05). Similarly, in the UKA group, OKS improved from 26.23 to 35.43 (p < 0.05) and KOOS from 50.12 to 65.91 (p < 0.05). However, the improvement in OKS and KOOS (delta) did not differ between groups (p = 0.35 and p = 0.95). The DFO and UKA groups were characterized by similar postoperative hip-knee-ankle (HKA) angle measurements of −3.26 and −3.00, respectively (p = 0.65). No patients in the UKA group underwent revision or other knee surgeries during follow-up. No infections were detected in either group. In the DFO group, no cases of nonunion or delayed union were reported. However, 40% of DFO patients underwent plate removal. One patient in each group was characterized by progression of medial OA with Kellgren-Lawrence (KL) grade > 3.

Conclusion
UKA and DFO represent an effective treatment in lateral knee OA with intra-articular and extra-articular deformity. Both surgeries were able to provide a significant and comparable clinical improvement.
Level of evidence: III, comparative retrospective cohort study.
Analysis of real-time PCR Melanocortin 3 (MC3R) gene expression to identify new biomarkers inflammation in tuberculosis
Authors: Tenriola Andi , Hidayah Najdah , Subair  , Massi Muhammad Nasrum , Halik Handayani , Damayanti Tri , Jafriati  , Rivai Andi Tenri Ola 
Published: July 2022

Abstract
Background
Diagnosis of tuberculosis (TB) in the era of technological sophistication requires accuracy and speed to provide as much information as possible so that TB treatment can be carried out quickly and precisely. New studies have also begun to be carried out to diagnose TB, one of which is by examining genes, either by looking at polymorphisms, mutations, or expressions. Several previous studies have confirmed the association of MC3R and TB genes with polymorphisms; MC3R is a gene that participates in the regulation of the inflammatory process and is also found in macrophages; therefore, we tried to analyze gene expression in the active TB group, household contacts, and healthy controls for looked at the differences between the three groups and confirmed the correlation of MC3R with TB by seeing which group's gene expression increased the most expression of the three groups so that the results can be considered as a TB diagnostic biomarker in the future.

Methods
This study included 122 people, 49 patients with confirmed TB, 46 close relatives of patients, and 27 healthy controls. This study used a real-time PCR technique to analyze MC3R gene expression in the three groups, and all data were analyzed using Bio-Rad CFXTM software version 3.1 and one-way ANOVA using SPSS 21.0.

Results
The value of MC3R gene expression in the active TB group increased 3.6-fold in the healthy group (p = 0.143), and that of gene expression in the healthy control group increased 1.09-fold in the healthy group (p = 0.007).

Conclusion
There is a relationship between MC3R and TB based on the results of gene expression analysis that increased in the active TB group compared to the household contact group and healthy controls.
Spin-orbit-locked hyperbolic polariton vortices carrying reconfigurable topological charges
Authors: Wang Mingsong , Hu Guangwei , Chand Saroj , Cotrufo Michele , Abate Yohannes , Watanabe Kenji , Taniguchi Takashi , Grosso Gabriele , Qiu Cheng-Wei , Alù Andrea 
Published: July 2022

AbstractThe topological features of optical vortices have been opening opportunities for free-space and on-chip photonic technologies, e.g., for multiplexed optical communications and robust information transport. In a parallel but disjoint effort, polar anisotropic van der Waals nanomaterials supporting hyperbolic phonon polaritons (HP2s) have been leveraged to drastically boost light-matter interactions. So far HP2 studies have been mainly focusing on the control of their amplitude and scale features. Here we report the generation and observation of mid-infrared hyperbolic polariton vortices (HP2Vs) associated with reconfigurable topological charges. Spiral-shaped gold disks coated with a flake of hexagonal boron nitride are exploited to tailor spin–orbit interactions and realise deeply subwavelength HP2Vs. The complex interplay between excitation spin, spiral geometry and HP2 dispersion enables robust reconfigurability of the associated topological charges. Our results reveal unique opportunities to extend the application of HP2s into topological photonics, quantum information processing by integrating these phenomena with single-photon emitters, robust on-chip optical applications, sensing and nanoparticle manipulation.
Interactive visualization of spatial omics neighborhoods
Authors: Xu Tinghui , Sankaran Kris 
Published: July 2022

Dimensionality reduction of spatial omic data can reveal shared, spatially structured patterns of expression across a collection of genomic features. We studied strategies for discovering and interactively visualizing low-dimensional structure in spatial omic data based on the construction of neighborhood features. We designed quantile and network-based spatial features that result in spatially consistent embeddings. A simulation compares embeddings made with and without neighborhood-based featurization, and a re-analysis of Keren et al., 2019 illustrates the overall workflow. We provide an R package, NBFvis, to support computation and interactive visualization for the proposed dimensionality reduction approach. Code and data for reproducing experiments and analysis are available on GitHub.
Modern approaches to address the concept of territorial division in Islamic jurisprudence
Authors: Alotaibi Hajed A. 
Published: July 2022

Background: This article examines how current jurists can deal with a juristic division of the world into abode of "Islam” and “infidelity". The success with which jurists re-evaluate this dichotomy will have major impacts on how an Islamic state interacts with non-Muslim governments on the one hand, and Muslims residing temporarily or permanently in a non-Muslim territory on the other. Methods: Here, an attempt made to review the concepts of Dar Al-Islam and Dar Al-Harb from two perspectives: that of the dialectical limits and liberalization, as discussed in secondary material such as books, research articles, and reports. Results: this paper has explored and discussed the criteria for identifying Dar Al-Islam and Dar Al-Harb in Islamic jurisprudence. Conclusions: This article analyzes the various arguments put forward to establish new ways of peaceful coexisting and maintaining healthy international connections.
Protocol for a randomized study of the efficacy of ibandronic acid plus eldecalcitol in patients with gastric cancer after gastrectomy: A comparative study of different routes of administration of ibandronic acid
Authors: Aiba Hisaki , Suzuki Nobuyuki , Sagawa Hiroyuki , Hashimoto Hiroya , Kimura Hiroaki , Inoue Jumpei , Usami Takuya , Goto Yuta , Mizuno Yuichiro , Okubo Tomotaka , Ito Sunao , Takiguchi Shuji , Murakami Hideki 
Published: July 2022

Background: Patients who undergo gastrectomy for gastric cancer are susceptible to osteoporosis. To prevent a decrease in bone mineral density, an appropriate prophylaxis is considered important to adjust the post-gastrectomy condition. In this study, we will compare two different routes of administration of ibandronic acid (oral or intravenous) plus eldecalcitol as a potentially more suitable treatment for patients at a high risk of fragile fracture. Protocol: This study protocol describes a randomized, active-controlled, non-blind, single-center, phase II trial. For patients in the investigational arm (Group A), sodium ibandronate hydrate will be administered intravenously once a month with daily oral intake of eldecalcitol; for those in the control arm (Group B), sodium ibandronate hydrate will be administered orally once a month with daily oral intake of eldecalcitol. We will recruit patients aged 20–85 years who have undergone gastrectomy for gastric cancer and are at a risk of fragility fractures. The study will include patients with existing vertebral fractures and/or femoral proximal fractures, or with lumbar and/or proximal femur bone mineral density of less than 80% of the young adult mean. The primary outcome of this study will be the change in lumbar bone mineral density. We will also evaluate the changes in femur bone mineral density, bone metabolism markers, health-related quality of life as evaluated using the EuroQol 5 Dimension (EQ-5D), and digestive symptoms as evaluated using the Gastrointestinal Symptom Rating Scale after 52 weeks of treatment. Conclusions: We believe that appropriate treatments that are adjusted to the condition of patients after gastrectomy are important for the prevention of bone mineral loss. Registration: This study was accepted by the Japan Registry of Clinical Trials (jRCT1041200059, November 6, 2021).
Protocol for a proof-of-concept study evaluating systematic quality improvement with Realtime event support (SQUIRES)
Authors: Montes de Oca Arianna , Budelier Thaddeus P. , Wolfe Rachel C. , Murray-Torres Teresa M. , Milbrandt Melissa , Guffey Ryan , Kronzer Alex , Bollini Mara L. , Torres Brian A. , Henrichs Bernadette , Ben Abdallah Arbi , McKinnon Sherry L. , Kangrga Ivan , Reidy Andrea , Kerby Paul W. , Avidan Michael S. , Wildes Troy S. 
Published: July 2022

Introduction: Quality improvement (QI) in healthcare results in better patient outcomes, healthcare system performance, and professional development. One target of QI initiatives in the perioperative period is surgical site infections (SSI), for which several risk factors have been identified. Reliable administration of indicated surgical antibiotic prophylaxis is a modifiable factor of particular relevance. We hypothesize that a novel telemedicine-augmented quality improvement program will improve administration of surgical antibiotic prophylaxis. Objectives: The objective of this QI study is to evaluate the utility of a telemedicine-augmented QI initiative on administration of timely surgical antibiotic prophylaxis. The incidence of SSI will also be reported for multiple surgical services. Methods: This will be a multi-center prospective before-and-after proof-of-concept study. Patients undergoing a surgical procedure across seven operating room facilities at four hospitals in the BJC Healthcare System will be included. Approximately 40,000 patients over an eight-month period will be enrolled. This eight-month period will include a baseline observational phase, an education intervention phase, an intervention phase employing real-time event detection with associated guidance from a remote telemedicine center, and a subsequent observational phase. The primary outcome will be administration of on-time surgical antibiotic prophylaxis throughout the trial. Other outcomes will include incidence of SSIs. Registration Information: This trial is registered on clinicaltrials.gov, NCT04983329 (30th July 2021).
OpenSAFELY: Representativeness of electronic health record platform OpenSAFELY-TPP data compared to the population of England
Authors: Andrews Colm , Schultze Anna , Curtis Helen , Hulme William , Tazare John , Evans Stephen , Mehrkar Amir , Bacon Sebastian , Hickman George , Bates Christopher , Parry John , Hester Frank , Harper Sam , Cockburn Jonathan , Evans David , Ward Tom , Davy Simon , Inglesby Peter , Goldacre Ben , MacKenna Brian , Tomlinson Laurie , Walker Alex 
Published: July 2022

Background: Since its inception in March 2020, data from the OpenSAFELY-TPP electronic health record platform has been used for more than 20 studies relating to the global COVID-19 emergency. OpenSAFELY-TPP data is derived from practices in England using SystmOne software, and has been used for the majority of these studies. We set out to investigate the representativeness of OpenSAFELY-TPP data by comparing it to national population estimates. Methods: With the approval of NHS England, we describe the age, sex, Index of Multiple Deprivation and ethnicity of the OpenSAFELY-TPP population compared to national estimates from the Office for National Statistics. The five leading causes of death occurring between the 1st January 2020 and the 31st December 2020 were also compared to deaths registered in England during the same period. Results: Despite regional variations, TPP is largely representative of the general population of England in terms of IMD (all within 1.1 percentage points), age, sex (within 0.1 percentage points), ethnicity and causes of death. The proportion of the five leading causes of death is broadly similar to those reported by ONS (all within 1 percentage point). Conclusions: Data made available via OpenSAFELY-TPP is broadly representative of the English population. Users of OpenSAFELY must consider the issues of representativeness, generalisability and external validity associated with using TPP data for health research. Although the coverage of TPP practices varies regionally across England, TPP registered patients are generally representative of the English population as a whole in terms of key demographic characteristics.
Ludzie starzy na wsi podlaskiej w dobie reform agrarnych w Rosji w XIX wieku
Authors: Kuklo Cezary 
Published: July 2022

Artykuł ma na celu przeanalizowanie roli i miejsca ludzi starych w rodzinie chłopskiej na Podlasiu, włączonym w końcu XVIII w. do Rosji, w czasie reform agrarnych dokonujących się w tym państwie w XIX w. Jego podstawę źródłową stanowią spisy mieszkańców parafii Trzcianne z 1843 i 1882 r. W efekcie dla badanego okresu określono nie tylko dominującą formę rodzinną ogółu chłopskich gospodarstw domowych, lecz także strukturę gospodarstw kierowanych przez seniorów (60 lat i więcej). Ponadto ustalono moment rezygnacji jednostki z pozycji głowy gospodarstwa, który wyznaczał początek starości i zmianę dotychczasowego statusu społecznego w obrębie wspólnoty rodzinnej i całej wsi oraz stopień izolacji rodzinnej i społecznej seniorów z uwzględnieniem ich płci. Temu służyło dokładniejsze poznanie powiązań osobowych wynikających z charakteru współmieszkania, z uwzględnieniem, obok pozycji zajmowanej w gospodar
Świat rzymskich monet.
Authors: Kluczek Agata Aleksandra 
Published: July 2022

Celem artykułu jest krytyczna ocena książki poświęconej życiu i karierze Margarete Bieber (1879–1978), wybitnej historyk i archeolog sztuki starożytnej, oraz zawierającej numizmatyczne studia kilku współczesnych autorów. Zasadniczą część tekstu stanowią uwagi o ikonografii monety rzymskiej, zwłaszcza monety imperialnej II i III stulecia, oraz o związkach między rzeźbą a monetami. Skupia się on na kwestiach metodologii i wartości poznawczej źródeł numizmatycznych.
Pengembangan media power point berbasis multimedia Ispring Suite 10 materi energi listrik
Authors: Zharfa Mustafid , Saputro Budiyono 
Published: July 2022

Tujuan penelitian (1) mengetahui tingkat kebutuhan media Power Point berbasis multimedia ispring suite.10 materi energi listrik di MadrasahIbtidaiyah saat ini, (2) mengetahui kelayakan media Power Point berbasis multimedia ispring suite.10 materi energi listrik, dan (3) mengetahui efektivitas media Power.Point berbasis multimedia ispring suite 10 terhadap hasil belajar materi energi listrik. Metode penelitian adalah Research.and.Development (R&D). Subyek penelitian adalah siswa kelas VI MI Al Falah Tanjungrejo dan guru Madrasah Ibtidaiyah. Hasil penelitian 1) hasil kondisi nyata penggunaan media pembelajaran saat ini 66% pendidik belum menggunakan media inovatif serta analisis kebutuhan menunjukkan rerata 3,40 (butuh) media pembelajaran; 2) pengembangan media power.point berbasis multimedia ispring suite 10 materi energi listrik melalui tahapan: (a) mencari data kondisi nyata dan analisis kebutuhan, (b) perancangan power point berbasis multimedia ispring suite 10, (c) FGD dengan ahli materi, ahli media dan guru, (d) revisi serta penilaian validator, maka memperoleh hasil rerata 3,50 (baik); 3) efektivitas pengembangan media power.point berbasis multimedia ispring.suite.10 dengan dilaksanakan 3 kali uji coba, yaitu: (a) uji coba perorangan memperoleh rerata skor 3,47 (baik), (b) uji coba kelompok memperoleh rerata skor 3,57 (sangat baik), (c) uji coba terbatas memperoleh rerata skor 3,62 (sangat baik). Hasil tersebut disimpulkan bahwa media ini sangat layak untuk digunakan, serta 3) uji efektivitas terhadap media power.point berbasis multimedia ispring suite 10 dengan menggunakan SPSS 16 diperoleh hasil data pretest 0,58 dan data posttest 0,220 signifikansi > 0,05 sehingga data terdistribusi dengan normal. Hasil Uji T memperoleh data 22.887, p=0,00<0,05. Hasil tersebut menunjukkan bahwa media power point berbasis multimedia ispring suite 10 materi energi listrik efektif terhadap prestasi belajar siswa kelas VI MI Al Falah Tanjungrejo.
A systematic analysis of preprints in Trauma & Orthopaedic surgery
Authors: Hodel Sandro , Selman Farah , Mania Sylvano , Maurer Steven M. , Laux Christoph J. , Farshad Mazda 
Published: July 2022

Aims Preprint servers allow authors to publish full-text manuscripts or interim findings prior to undergoing peer review. Several preprint servers have extended their services to biological sciences, clinical research, and medicine. The purpose of this study was to systematically identify and analyze all articles related to Trauma & Orthopaedic (T&O) surgery published in five medical preprint servers, and to investigate the factors that influence the subsequent rate of publication in a peer-reviewed journal. Methods All preprints covering T&O surgery were systematically searched in five medical preprint servers (medRxiv, OSF Preprints, Preprints.org, PeerJ, and Research Square) and subsequently identified after a minimum of 12 months by searching for the title, keywords, and corresponding author in Google Scholar, PubMed, Scopus, Embase, Cochrane, and the Web of Science. Subsequent publication of a work was defined as publication in a peer-reviewed indexed journal. The rate of publication and time to peer-reviewed publication were assessed. Differences in definitive publication rates of preprints according to geographical origin and level of evidence were analyzed. Results The number of preprints increased from 2014 to 2020 (p < 0.001). A total of 38.6% of the identified preprints (n = 331) were published in a peer-reviewed indexed journal after a mean time of 8.7 months (SD 5.4 (1 to 27)). The highest proportion of missing subsequent publications was in the preprints originating from Africa, Asia/Middle East, and South America, or in those that covered clinical research with a lower level of evidence (p < 0.001). Conclusion Preprints are being published in increasing numbers in T&O surgery. Depending on the geographical origin and level of evidence, almost two-thirds of preprints are not subsequently published in a peer-reviewed indexed journal after one year. This raises major concerns regarding the dissemination and persistence of potentially wrong scientific work that bypasses peer review, and the orthopaedic community should discuss appropriate preventive measures. Cite this article: Bone Jt Open 2022;3(7):582–588.
Octave-spanning frequency comb generation based on a dual-mode microcavity laser
Authors: Wang Ting , Wu Ji-Liang , Zhang Xu-Cheng , Shi Yang , Yang Yue-De , Xiao Jin-Long , Zhang Da-Ming , Qin Guan-Shi , Huang Yong-Zhen 
Published: July 2022

Octave-spanning optical frequency comb (OFC) generation has achieved great breakthroughs and enabled significant applications in many fields, such as optical clocks and spectroscopy. Here, we demonstrate octave-spanning OFC generation with a repetition rate of tens of GHz via a four-wave mixing (FWM) effect seeded by a dual-mode microcavity laser for the first time, to our knowledge. A 120-m Brillouin nonlinear fiber loop is first utilized to generate wideband OFCs using the FWM effect. Subsequently, a time-domain optical pulse is shaped by appropriate optical filtering via fiber Bragg gratings. The high-repetition-rate pulse train is further boosted to 11 pJ through optimal optical amplification and dispersion compensation. Finally, an octave optical comb spanning from 1100 to 2200 nm is successfully realized through the self-phase modulation effect and dispersion wave generation in a commercial nonlinear optical fiber. Using dual-mode microcavity lasers with different mode intervals, we achieve frequency combs with octave bandwidths and repetition rates of 29–65 GHz, and demonstrate the dual-mode lasing microcavity laser as an ideal seeding light source for octave-spanning OFC generation.
Generation of single solitons tunable from 3 to 3.8  μm in cascaded Er3+-doped and Dy3+-doped fluoride fiber amplifiers
Authors: Yu Linpeng , Liang Jinhui , Huang Shiting , Wang Jinzhang , Wang Jiachen , Luo Xing , Yan Peiguang , Dong Fanlong , Liu Xing , Lue Qitao , Guo Chunyu , Ruan Shuangchen 
Published: July 2022

High-power tunable femtosecond mid-infrared (MIR) pulses are of great interest for many scientific and industrial applications. Here we demonstrate a compact fluoride-fiber-based system that generates single solitons tunable from 3 to 3.8 μm. The system is composed of an Er:ZBLAN fiber oscillator and amplifier followed by a fusion-spliced Dy:ZBLAN fiber amplifier. The Er:ZBLAN fiber amplifier acts as a power booster as well as a frequency shifter to generate Raman solitons up to 3 μm. The Dy:ZBLAN fiber amplifier transfers the energy from the residual 2.8 μm radiation into the Raman solitons using an in-band pumping scheme, and further extends the wavelength up to 3.8 μm. Common residual pump radiation and secondary solitons accompanying the soliton self-frequency shift (SSFS) are recycled to amplify Raman solitons, consequently displaying a higher output power and pulse energy, a wider shifting range, and an excellent spectral purity. Stable 252 fs pulses at 3.8 μm with a record average power of 1.6 W and a pulse energy of 23 nJ are generated. This work provides an effective way to develop high-power widely tunable ultrafast single-soliton MIR laser sources, and this method can facilitate the design of other SSFS-based laser systems for single-soliton generation.