bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Nomogram to Predict Nodal Response after Induction Chemotherapy for Hypopharyngeal Carcinoma
Authors: Li Feiran , Hsueh Chiyao , Huang Huiying , Gong Hongli , Tao Lei , Zhou Liang , Zhang Ming 
Published: June 2022

BackgroundFor hypopharyngeal carcinoma, metastatic neck nodes with a low response to induction chemotherapy (ICT) should not be managed with concomitant chemoradiotherapy (CCRT), and the prediction of chemosensitivity before ICT could prevent adverse events from occurring during chemotherapy. In this study, we developed a nomogram to predict the regional response to ICT.MethodsA total of 153 hypopharyngeal carcinoma patients with regional metastasis treated with ICT in our institution from January 2010 to September 2020 were retrospectively studied. According to ICT response evaluated by RECIST 1.1, patients were divided into chemo‐insensitive (PR < 70%/SD/PD) (group 1) and chemosensitive (CR/PR ≥ 70%) (group 2) groups. Patients' clinical, image, and hematologic data before ICT were collected. The nomogram was built based on multivariate analysis and stepwise logistic regression and was evaluated from the aspects of discrimination and calibration.ResultsA nomogram based on five critical predictors, namely, tumor differentiation degree, T classification, metastatic lymph node size, number of lymph node metastases, and cervical nodal necrosis, was developed. The areas under the curve (AUC) values were 0.76 and 0.70 after adjusting the results using bootstrap methods. The calibration curve showed relatively good agreement between the predicted and observed probabilities.ConclusionsOur nomogram yielded good accuracy in predicting the regional ICT response and will be a useful tool to assist clinicians in decision making.Level of Evidence4 Laryngoscope, 133:849–855, 2023
Clinical impact of p16 positivity in nasopharyngeal carcinoma
Authors: Shimizu Yuri , Murakami Naoya , Mori Taisuke , Takahashi Kana , Kubo Yuko , Yoshimoto Seiichi , Honma Yoshitaka , Nakamura Satoshi , Okamoto Hiroyuki , Iijima Kotaro , Takahashi Ayaka , Kaneda Tomoya , Kashihara Tairo , Inaba Koji , Okuma Kae , Nakayama Yuko , Igaki Hiroshi , Itami Jun 
Published: June 2022

AbstractPurposeThe clinical characteristics and prognosis of HPV‐related nasopharyngeal cancer (NPC) remain controversial. The relationship between p16 status and outcome was retrospectively investigated in the NPC patients.Materials and MethodsBetween May 2009 and May 2019, 81 NPC patients who received definitive radiation therapy, in a hospital in Japan, were identified and the prognosis was investigated. p16, p53, and Epstein–Barr virus (EBV) status were assessed. Also, circumferential tumor extent in the nasopharyngeal cavity was assessed on a 5‐point scale.ResultsNine and 72 patients were p16‐positive and p16‐negative, respectively. Fewer patients were EBV‐encoded RNA in situ hybridization (EBER‐ISH)‐positive in the p16‐positive group than in the p16‐negative group (p < .01). Seventy‐five patients were nonkeratinizing NPCs, and six patients were keratinizing NPCs. There were two p16‐positive patients among the keratinizing NPCs.The mean circumferential tumor extent scores of 16‐positive and p16‐negative NPCs were 4.2 and 3.2, respectively with a statistically significant difference (p = .02). Two‐year progression‐free survival (PFS) of p16‐positive and p16‐negative patients undergoing chemoradiation therapy were 100% and 69%, respectively (p = .13).ConclusionIn this study conducted in Japan, p16‐positive NPC patients are minor but not very low, and the proportion of keratinizing NPCs was small. p16‐positive NPCs were seen both in keratinizing and nonkeratinizing NPCs. P16‐positive NPC had a tendency of better PFS than p16‐negative NPC. This better prognosis might be due to the higher radiosensitivity of the p16‐positive cell. Additionally, p16‐positive NPCs seemed to spread more extensively in circumference along the nasopharyngeal mucosa than p16‐negative NPCs.
Q‐switched Nd:YVO4 laser with TiS2 saturable absorber
Authors: Zhou Yu , Leng Weifeng , Sui Chao , Yang Hui , Li Mingxin 
Published: June 2022

AbstractIn this paper, the liquid‐phase ultrasonic stripping preparation method was used to fabricate a TiS2 saturable absorber (SA). A Q‐switched Nd:YVO4 laser was demonstrated using the TiS2 SA. The modulation depth and saturation power intensity of TiS2 SA were 4.5% and 19.7 MW/cm2, respectively. The maximum output power was 322 mW under 4.5 W with T = 10%, and the corresponding conversion efficiency was 7.16%. The pulse width was 476 ns with a repetition rate of 72.4 kHz, and the corresponding single pulse energy was 4.45 μJ. Thus, TiS2 nanosheet is a suitable SA material for Q‐switched lasers.
Tele‐medicine and improvement of mental health problems in COVID‐19 pandemic: A systematic review
Authors: Hatami Hossein , Deravi Niloofar , Danaei Bardia , Zangiabadian Moein , Shahidi Bonjar Amir Hashem , kheradmand Ali , Nasiri Mohammad Javad 
Published: June 2022

AbstractIntroductionTele‐medicine services have been developed in response to the COVID‐19 pandemic, which disrupts mental health services. The present study investigates the effectiveness of telephone‐delivered services for psychological disorders in the COVID‐19 pandemic.MethodsWe searched PubMed/Medline, Embase and Cochrane Controlled Register of Trials for relevant clinical studies up to February 1, 2022. Following terms were used: “severe acute respiratory syndrome”, “Coronavirus”, “Coronavirus infection”, “SARS‐CoV‐2”, “COVID‐19”, “mental disorder”, “mental health”, “mental health program”, “mental health service”, “psychiatric service”, “telemedicine”, “Telehealth”, “Tele‐health”, “Telecare”, “Mobile health”.ResultsTwelve relevant clinical articles were included in our study. Eight articles were parallel randomized controlled trials (RCTs), two were Quasi‐experimental, and one was a multicenter retrospective cohort study. A total of 1900 adults (18 years old or above that) were included. Online telecommunication methods like online apps and videoconference were the most common interventions. The most prevalent measured outcome was levels of anxiety and depression among participants. Eleven out of 12 articles showed a significant association between telemedicine and mental health improvement.ConclusionsThe included studies in the current systematic review reported the probable efficacy of telemedicine in improving mental health disorders during the COVID‐19 pandemic. But it is not possible to determine the best telecommunication method for each mental disorder in different populations and the preference of patients is still face to face therapy. So RCTs in different populations with previous mental disorders or chronic diseases are required to investigate the further telemedicine's efficacy on managing mental problems.
Metabolism of oxygen via T2 and interleaved velocity encoding: A rapid method to quantify whole‐brain cerebral metabolic rate of oxygen
Authors: Deshpande Rajiv S. , Langham Michael C. , Cheng Cheng‐Chieh , Wehrli Felix W. 
Published: June 2022

PurposeCerebral metabolic rate of oxygen (CMRO2) is an important biomarker of brain function. Key physiological parameters required to quantify CMRO2 include blood flow rate in the feeding arteries and venous oxygen saturation (SvO2) in the draining vein. Here, a pulse sequence, metabolism of oxygen via T2 and interleaved velocity encoding (MOTIVE), was developed to measure both parameters simultaneously and enable CMRO2 quantification in a single pass.MethodsThe MOTIVE sequence interleaves a phase‐contrast module between a nonselective saturation and a background‐suppressed T2‐prepared EPI readout (BGS‐EPI) to measure T2 of blood water protons and cerebral blood flow in 20 s or less. The MOTIVE and standalone BGS‐EPI sequences were compared against TRUST (“T2 relaxation under spin tagging”) in the brain in healthy subjects (N = 24). Variants of MOTIVE to enhance resolution or shorten scan time were explored. Intrasession and intersession reproducibility studies were performed.ResultsMOTIVE experiments yielded an average SvO2 of 61 ± 6% in the superior sagittal sinus of the brain and an average cerebral blood flow of 56 ± 10 ml/min/100 g. The bias in SvO2 of MOTIVE and BGS‐EPI to TRUST was +2 ± 4% and +1 ± 3%, respectively. The bias in cerebral blood flow of MOTIVE to Cartesian phase‐contrast reference was +1 ± 6 ml/min/100 g.ConclusionsThe MOTIVE sequence is an advance over existing T2‐based oximetric methods. It does not require a control image and simultaneously measures SvO2 and flow velocity. The measurements agree well with TRUST and reference phase‐contrast sequences. This noninvasive technique enables CMRO2 quantification in under 20 s and is reproducible for in vivo applications.
Physical therapists' perceptions of and satisfaction with delivering telerehabilitation sessions to patients with knee osteoarthritis during the Covid‐19 pandemic: Preliminary study
Authors: Alrushud Asma , Alamam Dalyah , Alharthi Ameerah , Shaheen Afaf , Alotaibi Nada , AlSabhan Rand , Alharbi Shatha , Ali Nour , Mohammed Elaf , Sweeh Joud 
Published: June 2022

AbstractObjectiveThis preliminary study was conducted to explore physical therapists' (PT) perceptions of and satisfaction with delivering telerehabilitation sessions to patients with knee osteoarthritis during the Covid‐19 pandemic.Study designAn exploratory preliminary study using an internet‐based survey followed by focus group sessions.MethodsA programme of sessions was administered by 12 PTs from the Physical Therapy Department at Prince Sultan Military Medical City. An internet‐based survey containing 17 statements was completed by the PTs.ResultsWith regard to telephone‐delivered care, four statements related to patients' privacy, programme convenience, safe patients time and money achieved consensus agreement (≥75% agreed or strongly agreed), there was majority agreement (≥50% of respondents agreed or strongly agreed) with seven of the statements regarding the effectiveness, affordability and safety of the programme, but there was no consensus with regard to the remaining five statements. In addition, most of the participants (84.6%) believed that a telephone consultation should cost 25% or 50% less than a face‐to‐face session.ConclusionDespite the lack of physical contact with patients, the PTs agreed that telerehabilitation would offer patients an easy method of being prescribed a therapeutic programme, save time and money, and maintain patient privacy. Further, the PTs reported barriers and suggested adaptations for this method of service delivery.
Reliability and validity of the Arabic version of the biological rhythms interview of assessment in neuropsychiatry
Authors: Murad Odeh S. , Al‐Dassean Khaled A. 
Published: June 2022

AbstractBackgroundDisruptions in biological rhythm (BR) are considered a factor in the spread of many chronic diseases such as hypertension, diabetes, and depression. It has been shown that imbalance in BR disrupts the body’s physiological timings; therefore, it is essential to have a tool for BR evaluation.MethodsA cross‐sectional study was conducted on a sample of 403 Jordanian participants (200 depressed people and 203 control groups). Classical test theory (CTT) was used to evaluate the psychometric properties of the Arabic version of BRIAN. We aimed to validate the Arabic version of Biological Rhythms Interview Assessment in Neuropsychiatry (BRIAN) by investigating its internal consistency and validity, assessing its factor structure, and exploring its relationships with depression and sleep disorders.ResultsThe internal consistency (α) was 0.91. The concurrent validity was supported by the severity of depression and sleep disorders (r = 0.87, r = 0.83, p < 0.001). The BRIAN’s ability to differentiate between depressed people and the control group supported its discriminant validity (t = 21.2, p = 0.001). With a sensitivity of 75 and a specificity of 95.57, BRIAN revealed good accuracy in distinguishing between depressed and non‐depressed persons at cutoff 44. The exploratory factor analysis (EFA) and the confirmatory factor analysis (CFA) analyses supported its proposed three‐factor solutions.ConclusionsThe results demonstrated that the BRIAN‐A has acceptable validity in detecting BR and could be useful in examining the impact of circadian disturbance on the Arabic population.
Fabrication and mechanical characterization of hybrid composite reinforced with nanoparticles of alumina and zirconia
Authors: Vij Vivek , Agarwal Raj , Garg Mohinder Pal , Khanna Rajesh , Gupta Vishal 
Published: June 2022

AbstractMetal matrix composites are rapidly gaining high attention in the automobile and aerospace industry due to their high performance, lightweight, and great mechanical strength. In this present study, metal matrix composite reinforced with nanoparticles is fabricated using the stir‐casting technique. The matrix of the aluminum is reinforced with the nanoparticles of alumina and zirconia in the weight percentage of 6.6% and 3.3%, respectively. For microscopic and mechanical characterization, different specimens were prepared following the standard of fabrication. The microstructural, elemental composition, and distribution along with the interaction of the reinforcement particles with the aluminum matrix are observed using energy‐dispersive X‐ray (EDX) and scanning electron microscopy (SEM) analysis. The mechanical properties of fabricated nanocomposite are compared with that of the monolithic aluminum metal. The microhardness of the specimen is investigated using a Vickers hardness testing machine. The tensile strength and flexural strength are evaluated using the universal testing machine. It was observed that the reinforcement particles were uniformly and homogeneously distributed in the aluminum matrix. It was witnessed that the mechanical strength was significantly improved during the tensile strength (54.32%) and hardness (114.28%) of the nanocomposite compared to the pure rolled aluminum. However, the flexural strength is reduced by 3.33% with the addition of the reinforcement particles.
A review on elastic graphene aerogels: Design, preparation, and applications
Authors: Xia Yuxing , Gao Chao , Gao Weiwei 
Published: June 2022

AbstractGraphene aerogels with unique properties, such as ultralow density, super‐elasticity, high specific surface area, and excellent thermal stability, have undergone great progress in the past decades. Especially, super‐elastic graphene aerogels provide a highly attention‐catching platform for developing advanced energy devices, pressure sensors, contaminates adsorbents, and electromagnetic wave shielding and absorption materials, and so forth. In this review, we begin with the introduction and discussion of various fabrication techniques and compare their advantages and disadvantages, focusing on the template‐free assembly process and template‐assisted assembly process. Then, we summarize the factors influencing the compressibility and elasticity of graphene aerogels, including intrinsic properties of building blocks, constituent materials, and structure design, and their wide applications. At the end, we discuss the current challenges and future prospects of this field.
Antisynthetase syndrome with rare EJ‐1 antibodies with antiphospholipid syndrome
Authors: Chhor Louis , Tu Steven , Fogarty Paul , Fong Christopher 
Published: June 2022

AbstractWe describe the first case of antisynthetase syndrome (ASS) with antibodies to anti‐glycyl tRNA synthetase (EJ‐1) with antiphospholipid syndrome (APLS). A 66‐year‐old man presented with progressive dyspnoea, fever, dry cough and proximal muscle weakness over several months on a background of cryptogenic organizing pneumonia. Examination revealed bibasal fine chest crackles, proximal muscle weakness of the upper and lower limbs, digital skin thickening and facial telangiectasias. Creatine kinase was elevated and autoimmune screening was positive for anti‐EJ‐1, anti‐beta‐2‐glycoprotein, anti‐Ro and anti‐La antibodies. Computed tomography of the chest revealed a usual interstitial pneumonia pattern and a ventilation–perfusion scan demonstrated scintigraphic evidence of bilateral pulmonary emboli. A diagnosis of ASS and APLS was made. Immunosuppressive therapy including pulsed methylprednisolone, rituximab and mycophenolate was commenced with improvement in symptoms. This case highlights the importance of evaluation for ASS in idiopathic interstitial pneumonia, and APLS in ASS patients.
Predictive maintenance of infrastructure code using “fluid” datasets: An exploratory study on Ansible defect proneness
Authors: Quattrocchi Giovanni , Tamburri Damian Andrew 
Published: June 2022

AbstractThis work consolidates and compounds previous investigations in recognizing defects for infrastructure‐as‐code (IaC) scripts using general software development quality metrics with a focus on defect severity but adding to previous work an explorative look at creating datasets, which may boost the predictive power of provided models—we call this notion a fluid dataset. More specifically, we experiment with 50 different metrics harnessing a multiple dataset creation process whereby different versions of the same datasets are rigged with auto‐training facilities for model retraining and redeployment in a DataOps fashion. At this point, with a focus on the Ansible infrastructure code language—as a de facto standard for industrial‐strength infrastructure code—we build defect prediction models and manage to improve on the state of the art by finding an F1 score of 0.52 and a recall of 0.57 using a Naive–Bayes classifier. On the one hand, by improving state‐of‐the‐art defect prediction models using metrics generalizable for different IaC languages, we provide interesting leads for the future of infrastructure‐as‐code. On the other hand, we have barely scratched the surface on the novel approach of fluid‐datasets creation and automated retraining of Machine Learning (ML) defect prediction models, warranting for more research on the same direction in the future.
Ein faltbares Dach für das Weinschloss Thaller
Authors: Paech Christoph , Plieninger Sven 
Published: June 2022

AbstractWandelbare Überdachungen und Fassaden eröffnen Bauherren und Betreibern völlig neue Nutzungsmöglichkeiten ihrer Immobilie. Durch den Einsatz hochfester Baumaterialien in Kombination mit sinnvollen und optimierten Tragsystemen lassen sich wandelbare Strukturen auch optimal in Bestandsgebäude integrieren. Die konsequente Anwendung des Strukturleichtbaus reduziert die zusätzlichen Lasten auf das Bestandstragwerk auf ein Minimum, gleichzeitig kann die Antriebstechnik der verfahrbaren Elemente vereinfacht werden. Neben seinen rein wirtschaftlichen Vorteilen zeichnet sich der optimierte Strukturleichtbau ebenso durch einen minimalen CO2‐Verbrauch in der Herstellung und im Betrieb eines wandelbaren Dachs aus. Im Frühjahr 2022 wurde ein neues adaptives Dach über dem Arkadenhof des Weinschlosses Thaller in der Steiermark errichtet. Das faltbare Dach mit einem Flächengewicht von nur 43 kg/m2 erlaubt dem Betreiber eine wetterunabhängige Nutzung des Arkadenhofs. Das Tragkonzept des 350 m2 großen verfahrbaren Dachs beruht auf dem Faltwerksprinzip und erlaubt einen einfachen und effizienten Antrieb. Die Kombination einer transparenten ETFE und einer transluzenten textilen Membraneindeckung garantiert tagsüber selbst bei geschlossenem Dach eine ausreichende natürliche Belichtung des Arkadenhofs. Nachts sorgt die farbige Beleuchtung der transluzenten Dachfläche für unterschiedliche Atmosphären.
Evaluating the influence of fly ash and waste glass on the characteristics of coconut fibers reinforced concrete
Authors: Aslam Fahid , Zaid Osama , Althoey Fadi , Alyami Saleh H. , Qaidi Shaker M. A. , de Prado Gil Jesús , Martínez‐García Rebeca 
Published: June 2022

AbstractThe disposal of waste from coal plants and waste glass (WG) is causing significant environmental problems all around the planet. Currently, the amount of discarding of these wastes is increased. One possible option is to utilize fly ash (FA) from coal plants as a partial substitute for the cement and EG as a fractional substitute for sand in concrete, respectively. Besides, fibers can improve the strength and durability of concrete; explicitly speaking, using coconut fibers (CFs) is in trend due to their highest toughness among natural fibers making it suitable material as fiber reinforcement in concrete. This research studies the concrete behavior with 15% FA as a partial substitute of cement with 2% CFs and waste beverage glass as sand at various replacement levels (14%, 15%, 16%, 17%, 18%, 19%, and 20%). Mechanical and durability characteristics of concrete were assessed, such as compression strength, water absorption, flexural strength, density, workability, and water absorption. The current study results show that adding FA, CFs, and WG improved microstructure quality at 16% replacement of sand. The study showed that the M4 mix has enhanced the properties of concrete samples as compressive and flexural strength was improved to 47.2 and 6.2 MPa and improved apparent density by 20%. Adding more WGP than the optimal proportion (16%) led to detrimental effects on void ratio, permeability, and water absorption. Therefore, 16% of sand with WG and 15% of FA with cement can be substituted with 2% CFs to develop sustainable concrete.
Tools and targets: The dual role of plant viruses in CRISPR–Cas genome editing
Authors: Uranga Mireia , Daròs José‐Antonio 
Published: June 2022

AbstractThe recent emergence of tools based on the clustered, regularly interspaced, short palindromic repeats (CRISPR) and CRISPR‐associated (Cas) proteins have revolutionized targeted genome editing, thus holding great promise to both basic plant science and precision crop breeding. Conventional approaches for the delivery of editing components rely on transformation technologies or transient delivery to protoplasts, both of which are time‐consuming, laborious, and can raise legal concerns. Alternatively, plant RNA viruses can be used as transient delivery vectors of CRISPR–Cas reaction components, following the so‐called virus‐induced genome editing (VIGE). During the last years, researchers have been able to engineer viral vectors for the delivery of CRISPR guide RNAs and Cas nucleases. Considering that each viral vector is limited to its molecular biology properties and a specific host range, here we review recent advances for improving the VIGE toolbox with a special focus on strategies to achieve tissue‐culture‐free editing in plants. We also explore the utility of CRISPR–Cas technology to enhance biotic resistance with a special focus on plant virus diseases. This can be achieved by either targeting the viral genome or modifying essential host susceptibility genes that mediate in the infection process. Finally, we discuss the challenges and potential that VIGE holds in future breeding technologies.