bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adenosine-Deaminase-Acting-on-RNA-1 Facilitates T-cell Migration toward Human Melanoma Cells
Authors: Margolis Naama , Moalem Hanna , Meirson Tomer , Galore-Haskel Gilli , Markovits Ettai , Baruch Erez N. , Vizel Bella , Yeffet Avner , Kanterman-Rifman Julia , Debby Assaf , Besser Michal J. , Schachter Jacob , Markel Gal 
Published: June 2022

Abstract

The effect of tumor/T-cell interactions on subsequent immune infiltration is undefined. Here, we report that preexposure of melanoma cells to cognate T cells enhanced the chemotaxis of new T cells in vitro. The effect was HLA class I–restricted and IFNγ-dependent, as it was abolished by β2M-knockdown, MHC-blocking antibodies, JAK1 inhibitors, JAK1-silencing and IFNgR1-blocking antibodies. RNA sequencing (RNA-seq) of 73 melanoma metastases showed a significant correlation between the interferon-inducible p150 isoform of adenosine-deaminase-acting-on-RNA-1 (ADAR1) enzyme and immune infiltration. Consistent with this, cocultures of cognate melanoma/T-cell pairs led to IFNγ-dependent induction of ADAR1-p150 in the melanoma cells, as visualized in situ using dynamic cell blocks, in ovo using fertilized chick eggs, and in vitro with Western blots. ADAR1 staining and RNA-seq in patient-derived biopsies following immunotherapy showed a rise in ADAR1-p150 expression concurrently with CD8+ cell infiltration and clinical response. Silencing ADAR1-p150 abolished the IFNγ-driven enhanced T-cell migration, confirming its mechanistic role. Silencing and overexpression of the constitutive isoform of ADAR1, ADAR1-p110, decreased and increased T-cell migration, respectively. Chemokine arrays showed that ADAR1 controls the secretion of multiple chemokines from melanoma cells, probably through microRNA-mediated regulation. Chemokine receptor blockade eliminated the IFNγ-driven T-cell chemotaxis. We propose that the constitutive ADAR1 downregulation observed in melanoma contributes to immune exclusion, whereas antigen-specific T cells induce ADAR1-p150 by releasing IFNγ, which can drive T-cell infiltration.
Two cross coupled and Madgwicks filter for estimation of multi-channel dividing systems
Authors: Kadhim Nader Abdullah , Alrubaie Ali jawad , Al-khaykan Ameer 
Published: June 2022

The estimates of Rayleigh fading channels are rapidly changing in multi carrier direct sequence code division multiple access (MC-DS-CDMA) multiplexing systems. The most widely accepted answer to this issue is the conventional solution least square (LS) or mean square error estimator (MMSE) using the recursive least squares algorithm (RLS) or the least mean squares (LMS) algorithm. In much of the previous work, only one Kalman filter was used for estimation. In this paper, a Kalman filter is used with a Madgwicks filter together to satisfy the fading problems. However, this requires a priori evaluation of auto regressive (AR) parameters. A standard solution involves the first matching of the auto-completion function of the applying the AR method to Jakes' problem and then tackling it (YWE). Even more the results procedure is limited to crowd constraints and is related to an AR+ process of noise, an approximation considered. In fact, depending on simulation findings, high-AR models outperform conventional models on the basis of spectral estimate and bit error margins (BER). Nevertheless, in order to save costs of computing, the 5-D model of AR is a possibility. The proposed process outperforms edge of art competitors in terms of bit error rate as demonstrated by results.
Improving the efficiency of machine learning models for predicting blood glucose levels and diabetes risk
Authors: Yothapakdee Kriengsak , Charoenkhum Sarawoot , Boonnuk Tanunchai 
Published: June 2022

Fasting <span>blood glucose is used as an indicator in the process of predicting diabetes risk. This research aims to, i) create a model for predicting blood glucose level using data mining algorithms, ii) a selection algorithm was used to select a feature from the correlation of the data, and iii) to compare the model's performance with the classical methods. All clinical data ware recorded and compiled in a database by hospital staff from 2014-2019. In our previous research, the blood glucose prediction model had an acceptable accuracy where 18 patient features were used as input data to the data mining process. In this research, we demonstrated that the random forest classifier and extra tree classifier algorithms have an outstanding in discarding non-critical attributes. And the process of reducing the number of those features has impacted the glycemic prediction model with higher efficiency. Seventeen machine learning algorithms are used to find the best performance models. Our results clearly show that the improved prediction model is more efficient. This experiment has shown that improvements to our proposed model were able to predict blood glucose levels with 99.69% and 99.63% accuracy for random forest classifier, extra tree classifier, and Gaussian process classifier, respectively.</span>
Open network structure and smart network to sharing cybersecurity within the 5G network
Authors: Ahmed Aseel K. , Khorsheed Abbas Akram 
Published: June 2022

The <span>next-generation communication system incorporates information technology (IT) and operations technology (OT) for generating, delivering, and collecting, and obtaining communication power. We plan to include a brief outline of internet of thing (IoT) communication and its context, along with security concerns that arise for IoT data on the network and some methods for detecting and avoiding cyber security threats. With the rise of the 5G networks, we introduce the smart network's emergent technology and its opportunities and more cybersecurity issues. Whereas, finding or responding to a power outage is an essential part of system security That is why we will discuss the innumerable advantages of 5G networks and we must also cover the inevitable problems that we will encounter in power delivery. The use of smart IoT communication technologies is becoming more common in the energy sector, particularly with the network (5G. The smart network and energy flow integration Real-time data on generation, electricity distribution, and energy consumption is measured using computers and cutting-edge technologies. This information aids utility companies in managing electricity supply and demand, as well as price. While enhanced communication and information technologies are unquestionably crucial to </span>the smart network.
Myocardial Injury in Patients With Acute and Subacute Chagas Disease in the Brazilian Amazon Using Cardiovascular Magnetic Resonance
Authors: Couceiro Katia do Nascimento , Ortiz Jessica Vanina , Hosannah da Silva e Silva Mônica Regina , Teixeira de Sousa Débora Raysa , Andrade Rubens Celso , Brandão Alba Regina Jorge , de Morais Rômulo Freire , Smith Doria Susan , Fonseca Rafael Almeida , da Silva Paula Rita Leite , Fernandes Fabio , Guerra Maria das Graças Vale Barbosa , Rochitte Carlos Eduardo , Ferreira João Marcos Bemfica Barbosa , Guerra Jorge Augusto de Oliveira 
Published: June 2022

Background
Chagas disease is a neglected tropical disease that is still considered a global health emergency. In the Amazon region, most of the reports are of acute cases that are associated with oral transmission. This study aimed to evaluate myocardial injury in patients with acute Chagas disease before and after treatment.

Methods and Results
We evaluated 23 patients with acute Chagas disease in 3 different stages of progression. Group 1 had 12 patients evaluated during the acute phase, at the time of diagnosis, and 1 year after treatment, and Group 2 had 11 patients in the late postacute phase who were evaluated 5.2 years on average after diagnosis and treatment. ECGs with the Selvester score, 24‐hour Holter exam, and cardiovascular magnetic resonance imaging were performed. The mean age of the 23 patients was 44.3±18.9 years, and they were mostly men (15/65.24%) from Amazonas state (22/95.6%). In 69.6% (n=16) of the patients, some ECG alterations were found, the most frequent being left anterior fascicular block and ventricular repolarization. In Group 1, the 24‐hour Holter exam showed atrial tachycardia in 3 (25%) patients and ventricular extrasystoles in 2 (16.7%) patients. In Group 2, 1 patient had ventricular extrasystoles. Myocardial injury was observed in 7 patients (58.3%) at the acute phase and in 5 (50%) patients at the 1‐year follow‐up in Group 1 and in 2 (18.2%) patients in Group 2.

Conclusions
This article describes, for the first time, myocardial injury shown by cardiovascular magnetic resonance imaging in a group of patients with acute Chagas disease and reveals the importance of early detection and follow‐up of the cardiac impairment in these patients.
Integrated Multilayer Omics Reveals the Genomic, Proteomic, and Metabolic Influences of Histidyl Dipeptides on the Heart
Authors: Yan Keqiang , Mei Zhanlong , Zhao Jingjing , Prodhan Md Aminul Islam , Obal Detlef , Katragadda Kartik , Doelling Benjamin , Hoetker David , Posa Dheeraj Kumar , He Liqing , Yin Xinmin , Shah Jasmit , Pan Jianmin , Rai Shesh , Lorkiewicz Pawel Konrad , Zhang Xiang , Liu Siqi , Bhatnagar Aruni , Baba Shahid P. 
Published: June 2022

Background
Histidyl dipeptides such as carnosine are present in a micromolar to millimolar range in mammalian hearts. These dipeptides facilitate glycolysis by proton buffering. They form conjugates with reactive aldehydes, such as acrolein, and attenuate myocardial ischemia–reperfusion injury. Although these dipeptides exhibit multifunctional properties, a composite understanding of their role in the myocardium is lacking.

Methods and Results
To identify histidyl dipeptide–mediated responses in the heart, we used an integrated triomics approach, which involved genome‐wide RNA sequencing, global proteomics, and unbiased metabolomics to identify the effects of cardiospecific transgenic overexpression of the carnosine synthesizing enzyme, carnosine synthase (Carns), in mice. Our result showed that higher myocardial levels of histidyl dipeptides were associated with extensive changes in the levels of several microRNAs, which target the expression of contractile proteins, β‐fatty acid oxidation, and citric acid cycle (TCA) enzymes. Global proteomic analysis showed enrichment in the expression of contractile proteins, enzymes of β‐fatty acid oxidation, and the TCA in the Carns transgenic heart. Under aerobic conditions, the Carns transgenic hearts had lower levels of short‐ and long‐chain fatty acids as well as the TCA intermediate—succinic acid; whereas, under ischemic conditions, the accumulation of fatty acids and TCA intermediates was significantly attenuated. Integration of multiple data sets suggested that β‐fatty acid oxidation and TCA pathways exhibit correlative changes in the Carns transgenic hearts at all 3 levels.

Conclusions
Taken together, these findings reveal a central role of histidyl dipeptides in coordinated regulation of myocardial structure, function, and energetics.
Temporal Changes in Beat‐to‐Beat Variability of Repolarization Predict Imminent Nonsustained Ventricular Tachycardia in Patients With Ischemic and Nonischemic Dilated Cardiomyopathy
Authors: Amoni Matthew , Ingelaere Sebastian , Moeyersons Jonathan , Vandenberk Bert , Claus Piet , Lemmens Robin , Van Huffel Sabine , Sipido Karin , Varon Carolina , Willems Rik 
Published: June 2022

Background
An increase in beat‐to‐beat variability of repolarization (BVR) predicts arrhythmia onset in experimental models, but its clinical translation is not well established. We investigated the temporal changes in BVR before nonsustained ventricular tachycardia (nsVT) in patients with implantable cardioverter defibrillator (ICD).

Methods and Results

Patients with nsVT on 24‐hour Holter before ICD implantation for ischemic cardiomyopathy (ischemic cardiomyopathy+nsVT, n=43) or dilated cardiomyopathy (dilated cardiomyopathy+nsVT, n=37), matched ICD candidates without nsVT (ischemic cardiomyopathy‐nsVT, n=29 and dilated cardiomyopathy‐nsVT, n=26), and patients without ICD without structural heart disease (n=50) were studied. Digital Holter recordings from these patients were analyzed using a modified fiducial segment averaging technique to detect the QT interval. The nsVT episodes were semi‐automatically identified and QT‐BVR was assessed 1‐, 5‐, and 30‐minutes before nsVT, and at rest (at 3:00
am
). Resting BVR was higher in ICD patients compared with controls without structural heart disease. In ICD patients with nsVT, BVR increased significantly 1‐minute pre‐nsVT in ischemic cardiomyopathy (2.21±0.59 ms, versus 5 minutes pre‐nsVT: 1.78±0.50 ms,
P
<0.001) and dilated cardiomyopathy (2.09±0.57 ms, versus 5‐minutes pre‐nsVT: 1.58±0.51 ms,
P
<0.001), but not in patients without nsVT. In multivariable Cox regression analysis, pre‐nsVT BVR was a significant predictor for appropriate therapy during follow‐up.

Conclusions
Baseline BVR is elevated and temporal changes in BVR predict imminent nsVT events in patients with ICD independent of underlying cause. Real‐time BVR monitoring could be used to predict impending ventricular arrhythmia and allow preventive therapy to be incorporated into ICDs.
Extended Anticoagulation After Pulmonary Embolism: A Multicenter Observational Cohort Analysis
Authors: Chopard Romain , Albertsen Ida Ehlers , Ecarnot Fiona , Guth Sebastien , Besutti Matthieu , Falvo Nicolas , Piazza Gregory , Meneveau Nicolas 
Published: June 2022

Background
Pulmonary embolism (PE) has a long‐term risk of adverse events, which can be prevented by extended anticoagulation. We compared clinical characteristics and outcomes between patients treated with 2‐year extended anticoagulation and those who were not, in a population who had completed an initial phase of 3 to 6 months of anticoagulant therapy after acute PE.

Methods and Results

Observational cohort analysis of patients with PE who survived an initial phase of 3 to 6 months anticoagulation. Primary efficacy outcome was all‐cause death or recurrent venous thromboembolism. Primary safety outcome was major bleeding. In total, 858 (71.5%) patients were treated with and 341 (28.5%) were treated without extended anticoagulant therapy during the active study period. Age <65 years, intermediate‐high or high‐risk index PE, normal platelet count, and the absence of concomitant antiplatelet treatment were independently associated with the prescription of extended anticoagulation. The mean duration of the active phase was 2.1±0.3 years. The adjusted rate of the primary efficacy outcome was 2.1% in the extended group and 7.7% in the nonextended group (
P
<0.001) for patients treated with extended anticoagulant therapy. Rate of bleeding were similar between the extended anticoagulant group and the nonextended group.

Conclusions
Extended oral anticoagulation over 2 and a half years after index PE seems to provide a net clinical benefit compared with no anticoagulation in patients with PE selected to receive extended anticoagulation. Randomized clinical trials are warranted to explore the potential benefit of extended anticoagulation in patients with PE, especially those with transient provoking factors but residual risk.
Realisation of Children’s Rights under the UN Convention on the Rights of the Child to, in, and through Sexuality Education
Authors: Bourke Ashling , Mallon Benjamin , Maunsell Catherine 
Published: June 2022

Abstract
Through the framework of the Convention of the Rights of the Child (uncrc), this paper argues that quality sexuality education is fundamental to the realisation of rights for children and young people, particularly those related to their identity, sexual lives and relationships. Beyond the right to education itself and sexual health, sexuality education supports the realisation of a wide range of children’s rights including wellbeing, protection, participation, identity and equality. The paper argues for the specific ways in which quality sex education supports the realisation of such rights and argues for the universal need for such education to be participative to allow children and young people to make empowered decisions about their sexuality and relationships with others.
Identification and removal of aircraft clutter to improve wind velocity measurement made with Chung-Li VHF Radar
Authors: Chen Meng-Yuan , Su Ching-Lun , Chang Yuan-Han , Chu Yen-Hsyang 
Published: June 2022

Abstract
In this study, a data processing based on the empirical mode decomposition (EMD) of Hilbert-Huang Transform (HHT) is developed at Chung-Li VHF radar to identify and remove the aircraft clutter for improving the atmospheric wind measurement. The EMD decomposes the echo signals into the so-called intrinsic mode functions (IMFs) in the time domain, and then the aircraft clutter that is represented by a number of specific IMFs can be identified in the radar returns and separated from the clear air echoes that are observed concurrently by the VHF radar. The identified clutter is validated by using the aircraft information collected by the Automatic Dependent Surveillance-Broadcast (ADS-B) receiver. It shows that the proposed algorithm can detect the aircraft echoes that are mixed with the clear air echoes. After implementing the algorithm on the experimental data, the atmospheric horizontal wind velocities are estimated after the aircraft clutter is removed. In order to evaluate the degree of the improvement of the horizontal wind measurement, a comparison in the horizontal wind velocities between Chung-Li VHF radar and a co-located UHF wind profiler radar is made. The results show that the use of EMD and the proposed data processing can effectively reduce the uncertainty and substantially improve the precision and reliability of the horizontal wind measurement.
C-Reactive Protein and Specific Depression Symptoms Among Older Adults: An Exploratory Investigation of Multi-Plane Networks Using Cross-Sectional Data From NHANES (2017–2020)
Authors: Lee Chiyoung , Min Se Hee , Niitsu Kosuke 
Published: June 2022

Introduction Studies investigating the association between C-reactive protein (CRP) and depression among older adults have yielded inconsistent results. We suspect that this may be due to varying associations between CRP and particular depression symptom criteria, and we addressed this challenge using network analysis. Methods We used cross-sectional data from prepandemic National Health and Nutrition Examination Survey questionnaires (2017–2020) and included a sample of 1698 adults aged 65 years or older. Depression symptoms were assessed using the Patient Health Questionnaire-9. Unregularized Mixed Graphical Models were estimated using the R package mgm before and after adjusting for relevant sociodemographic, clinical, and lifestyle covariates. Results In the model with no covariates, the only symptom criterion associated with CRP was “appetite problems.” This association remained robust after controlling for all covariates. Although not associated with CRP, other criteria such as “fatigue” and “concentration difficulty” showed associations with important covariates for older adults such as white blood cell count or hemoglobin, respectively. Discussion The CRP-related variability in the depression symptom network that we have demonstrated may help explain the reported inconsistencies. The present study stands as exploratory, and future research should focus on applying longitudinal designs and including several other inflammatory proteins and covariates that were not measured in the current network model.
Patterns of longitudinal medical treatment of pediatric patients ever-diagnosed with attention deficit hyperactive disorder: A community-based, retrospective, naturalistic study
Authors: Ben Shoham Assaf , Shefer Galit , Tsafrir Shlomit 
Published: June 2022

Background Pharmacological treatment for ADHD exhibits much variation. Longitudinal prescription-filling trajectories are interesting objects to explore. The goal of this study is to identify distinct patterns of longitudinal prescription filling among pediatric patients who were ever diagnosed with ADHD. Methods Longitudinal data of ADHD-specific prescription filling during 2010–2019 of children diagnosed with ADHD during 2000–2019 who were 4–17-years-old at the time of diagnosis was obtained. Clustering of prescription-filling vectors was performed using K-means. Results Analysis of 57,110 prescription vectors yields five distinct patterns: high intensity treatment, from early childhood to late teens (5.7%); moderate intensity, from early childhood to late teens (13.3%); high intensity, from late childhood to late teens (6.1%); moderate intensity, from late childhood to late teens (14.2%); and low intensity, sporadic treatment (60.7%). These patterns correspond with observed clinical presentations. Conclusions Identifying longitudinal prescription-filling patterns substantiates and qualifies the variation in long-term efficacy of pharmacological treatment for ADHD in a treatment-as-usual community setting. Prescription-filling implies that symptoms are present, and that treatment is efficacious, as perceived by parents' and carers. Prolonged pharmacological treatment was perceived to have had a positive net value for 40% of the children, which under appropriate reservations, provides weak evidence of efficacy.
Patient-reported outcome measures in MS: Do development processes and patient involvement support valid quantification of clinically important variables?
Authors: Bharadia Trishna , Vandercappellen Jo , Chitnis Tanuja , Eelen Piet , Bauer Birgit , Brichetto Giampaolo , Lloyd Andrew , Schmidt Hollie , King Miriam , Fitzgerald Jennifer , Hach Thomas , Hobart Jeremy 
Published: June 2022

Background Patient-reported outcomes (PROs) are widely measured in multiple sclerosis (MS) studies. However, the quality of instrument development processes varies, raising concerns about the meaningfulness of associated data. Objectives To review the development of selected PROs commonly used in MS studies, including definitions of the concepts measured, use of conceptual frameworks, and degree of input from people living with MS (PlwMS). To gain insights and recommendations from PlwMS on their experience with these PROs. Methods We assessed 6 PROs (FSIQ-RMS, modified-FIS, MSQoL-54, Leeds 8-item MSQoL, MSIS-29 and EQ-5D) for alignment with regulatory and scientific requirements on PRO structure/development. PlwMS evaluated the degree to which the PROs reflect disease aspects they perceive important. Results Definitions, clarifications and conceptualisations of the measurement variables were often lacking. PlwMS were variably involved in PRO development. Ethnic diversity was rarely documented. PlwMS identified individualisation, ease of understanding, time burden, and mode of administration as factors affecting PRO usability. Conclusions To date, the PRO development process has consistently lacked clear definitions of concepts of interest, use of conceptual frameworks and patient involvement, thereby compromising the validity of data they generate. PRO instrument development must be conducted more robustly to maximise the value of pivotal clinical trials.