bluuebunny/crossref_metadata_2025_split huggingface dataset:
Problematyka przedawnienia roszczeń w zakresie umów kredytów frankowych. Część 2
Authors: Makowski Bartłomiej 
Published: June 2022

Początek XXI wieku to czas masowego udzielania przez banki kredytów denominowanych lub indeksowanych do franka szwajcarskiego. Kredytobiorcy, zapewniani o bezpieczeństwie i korzyściach, jakie niosą z sobą „kredyty frankowe”, podpisywali umowy zawierające liczne wady prawne, w tym niedozwolone postanowienia umowne (klauzule abuzywne). Aktualnie problemy takich umów kredytowych, jak abuzywność klauzul przeliczeniowych, niedopełnianie przez banki obowiązków informacyjnych wobec klienta przy zawieraniu umów oraz inne naruszenia przepisów prawa bankowego i cywilnego, mocno zajmują sądy krajów członkowskich UE, w tym sądy polskie, oraz TSUE. Kwestią dyskusyjną jest jednak przede wszystkim fakt uznawania tego rodzaju umów za nieważne w całości oraz związana z tym konieczność dokonania rozliczenia stron z tytułu coraz częstszego orzekania przez sądy nieważności tego rodzaju umów.
Rozważania zawarte w niniejszym artykule skupiają się na niezwykle istotnej na tle wskazanych sporów o nieważność umów kredytowych problematyce przedawnienia roszczeń kredytobiorców, którzy pozywając banki, żądają zwrotu uiszczonych przez nich na rzecz banków nienależnych ich zdaniem świadczeń od samego momentu zawarcia umowy. Wnikliwej analizie poddane zostało orzecznictwo sądów polskich oraz TSUE, którego wyroki wskazują, że bieg terminu przedawnienia może rozpocząć się dopiero z chwilą nabycia przez kredytobiorcę świadomości, iż zawarta przez niego umowa jest wadliwa, dzięki czemu możliwe staje się skuteczne wytoczenie powództwa.
Deformation Stability Response of Adjacent Subway Tunnels considering Excavation and Support of Foundation Pit
Authors: Liu Baohua , Lin Hang , Chen Yifan , Liu Jingshuo , Guo Chun 
Published: June 2022

Abstract
Since the safety and stability of the original tunnel structure are easily affected by the adjacent foundation pit excavation, it is strongly necessary to study the deformation evolution of tunnels during the adjacent foundation pit excavation. With regard to the two cases that tunnel is adjacently located at the right and bottom of foundation pit, the influence of different supporting methods, including pile support, bolt support, pile-bolt support, and shotcrete-bolt support, on the tunnel stability was investigated on the basis of the whole excavation process numerical simulation of deep foundation pit for determining the best foundation pit supporting beneficial to the stability of adjacent tunnel. The results indicate that both one-step excavation and multistep excavation have great influences on the displacement of adjacent tunnels, wherein the influences on the tunnel located at the right of foundation pit are greater than those at the bottom of foundation pit. Multistep excavation is recommended for the foundation pit adjacent to shallow tunnel. In the case of the tunnel located on the bottom of the foundation pit, the maximum stress generated around the tunnel is small, the maximum stress area is limited, and the displacement of tunnel monitoring points is also small. For the tunnel located at the right of the foundation pit, the pile-bolt supporting can effectively limit the displacement of soil between the tunnel and the foundation pit, reduce the maximum stress and the maximum stress distribution area, and effectively control the tunnel displacement.
Experimental Investigation on Strength and Crack Mechanism of Rock-Like Samples with Open-Closed Cross-Flaws under Uniaxial Compression
Authors: Le Huilin , Wei Jihong , Sun Shaorui , Lv Yi 
Published: June 2022

Abstract
Rock masses with open-closed cross-flaws are common in nature. The open-closed cross-flaws usually control the strength of rock masses. However, studies about the influence of open-closed cross-flaws on cracking behaviors and mechanical properties of rock masses are rare. In this study, rock-like samples containing open-closed cross-flaws with different geometries were fabricated to be conducted uniaxial compressive tests. The cracks observed in the tests were classified to nine types, and two new crack modes were described and identified. Two failure modes, failure caused by tensile cracks and failure caused by the combined effect of tensile and shear cracks, were observed. The failure caused by the penetration of the rock bridge is not observed, indicating that the rock bridge is not a potential penetration path for the samples with cross-flaws. Experimental results show that, when α=0°, the peak stress decreases from 32.2 MPa to 17.0 MPa as β increases from 0° to 90°. When α=90°, the peak stress increases from 22.5 MPa to 40.0 MPa as β increases from 0° to 90°. The inclination angle of the open flaw has an obvious effect on the strength of samples. When the inclination angle of the open flaw is 0°, the peak stress is the lowest (17.0 MPa). When the inclination angle of the open flaw is 90°, the peak stress is the largest (40.0 MPa). The samples with an open flaw of large inclination angle tend to have great compressive strength. For samples with open-closed cross-flaws, the open flaw has a greater influence on the strength and failure mode than the closed flaw.
Effect of Oil Viscosity on Flow Pattern Transition of Upward Gas-Oil Two-Phase Flow in Vertical Concentric Annulus
Authors: Yin Bangtang , Pan Shaowei , Zhang Xuxin , Wang Zhiyuan , Sun Baojiang , Liu Hongtao , Zhang Quan 
Published: June 2022

Summary
Gas-oil two-phase flow usually occurs during gas influx into the wellbore annulus of deepwater drilling with oil-based drilling fluid or gas-oil production from the wellbore annulus. A flow pattern transition often is used in well control or in production parameter design. Related studies primarily have focused on gas-water two-phase flow, which is significantly different from gas-viscosity oil two-phase flow. We conducted experiments on a facility that included a flow section that was 13 000 mm long, with a 60-mm inner pipe and a 100-mm outer pipe in the annulus. A range of oil viscosities from 16 to 39 mPa∙s has been studied. The superficial gas and oil velocities varied from 0.55 to 17.077 m/s and from 0 to 0.414 m/s, respectively. A flow pattern was identified based on visualized analysis using electrical capacitance volume tomography (ECVT) and void faction wave analysis. Flow pattern maps of different viscosities were plotted based on measured data. Transition criteria based on Froude number and Archimedes number were established. The new model was compared with gas-water two-phase flow transition models and validated with experimental data. The effect of viscosity on flow pattern transition was revealed. The transition boundary of the bubble to slug flow and slug to churn flow both moved in the direction of smaller superficial gas velocity with an increase in oil viscosity. There may exist a critical viscosity value when churn flow transited to annular flow. When the viscosity was lower than this critical point, the above result was the same for churn to annular flow when the superficial oil velocity was low. With an increase in the superficial oil velocity, however, the boundary gradually changed to high superficial gas velocity as the oil viscosity increased. When the viscosity was larger than the critical point, the oil viscosity had a slight influence on the transition.
Groundwater levels hierarchical clustering and regional groundwater drought assessment in heavily drafted aquifers
Authors: Yin Jina , Medellín-Azuara Josué , Escriva-Bou Alvar 
Published: June 2022

Abstract
Groundwater overexploitation along with decreasing precipitation exacerbates groundwater level decline and causes groundwater drought. Efficient assessment of the drought is critical to water management, especially in drought-prone agriculture regions. It remains challenging to characterize groundwater drought quantitatively due to the difficulty in obtaining groundwater observation data and the complexity of groundwater flow systems. To this end, agglomerative hierarchical cluster analysis was performed on long-term groundwater levels to classify wells in the San Joaquin River Basin, California. A Modified Mann–Kendall (MMK) test was undertaken to detect seasonal groundwater level trends from 1980 to 2019, and the magnitude was calculated using Sen's slope estimator. A nonparametric Standardized Groundwater level Index (SGI) was used to quantify the characteristics of groundwater drought. Results show that long-term (40-year) temporal patterns in groundwater levels varied significantly over the San Joaquin River Basin. Significantly decreasing trends were observed among more than 34.6% of wells, with an average decline of 0.69 m/year. Wells suffered frequent and severe groundwater droughts in the last decade, which were mainly driven by heavy groundwater exploitation. Findings provide useful information about the long-term behavior of regional groundwater levels, which in turn help stakeholders monitor droughts and adapt groundwater management strategies.
A comprehensive framework model for the trend, period and evaluation of the precipitation enhancement effect: TPEM
Authors: Liu Chengshuai , Sun Yue , Yu Qiying , Niu Chaojie , Soomro Shan-e-hyder , Hu Caihong 
Published: June 2022

Abstract
In this study, a framework model (TPEM) for evaluating the temporal and spatial variation of urban precipitation is established. TPEM includes seven calculation methods at the same time. Taking the annual precipitation and flood season precipitation data of eight meteorological stations in Zhengzhou, China, from 1960 to 2020 as an example, the trend and period of rain island effect in Zhengzhou are analyzed from the annual and flood season rainfall scale, and the distance method is introduced to quantitatively evaluate the rain island effect. The results show that the rain island effect in the central urban area of Zhengzhou has a sudden increase trend in 1997 and 2004 respectively, and the increasing trend of rain island effect on the scale of annual and flood season rainfall lasts for four and ten years respectively. At the same time, it has fluctuation periods of 8–10a, 16–18a, 3–5a, 17–20a, 5–7a, and 2–3a respectively. The rain island effect in Zhengzhou is concentrated in the flood season. The research can provide a scientific basis for cities to deal with the rain island effect in the future.
Survival-related Factors in HIV/AIDS Patients: A Retrospective Cohort
Study from 2011 to 2019 in Kermanshah, Iran
Authors: Ghadiri Keyghobad , Lorestani Roya Chegene , Kazemisafa Narges , Rostamian Mosayeb , Akya Alisha , Rezaeian Shahab , Bashiri Homayoon , Jasemi Seyed Vahid 
Published: June 2022

Introduction:
Accurate evaluation of the survival rate among HIV-positive populations is pivotal for HIV management.

Objective:
This study aimed to investigate the survival rate and potential survival-related factors in HIV/AIDS patients from 2011 to 2019 in the city of Kermanshah in the west of Iran.

Method:
In this study, 915 HIV-positive patients registered by the Kermanshah Behavioral diseases counseling center, were surveyed from 2011 to 2019. By reading the patients' files, the proper data related to the survival factors were extracted and statistically analyzed.

Results:
Of 915 patients, 220 (24%) died. The one-year, five-year, and ten-year survival rates were 84%, 72%, and 62%, respectively. There was a significant relationship between the survival rate and many other parameters, including treatment variables, CD4+ T cell count, the way of HIV transmission, level of education, gender, and marital status. Over time, timely initiation of treatment has increased. The data also showed that HIV transmission through drug injection has decreased, while the sexual transmission of HIV has increased.

Conclusions:
The results showed that in recent years, due to the appropriate treatment, the survival rate of HIV patients has increased. The highest risk factor of death was for people with low CD4+ T cell count, lack of antiretroviral therapy, low level of education, male gender, and people who inject drugs. These people need more attention to get tested for HIV- related indexes and to receive proper treatment.
Serum Level of Soluble Human Leukocyte Antigen G in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis
Authors: khodashahi Mandana , Rezaieyazdi Zahra , Rezaeian Amin 
Published: June 2022

Background:
This study aimed to evaluate the serum level of human leukocyte antigen
G [HLA-G] in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)
compared to healthy controls; moreover, it attempted to assess its relationship with SLE and RA
disease activity indices.

Methods:
This descriptive study was conducted on 31 SLE patients (17 cases with a recent diagnosis
and 14 cases with a previous diagnosis), 21 RA patients (7 cases with a recent diagnosis and 14
cases with a previous diagnosis), and 18 healthy controls who visited Ghaem Hospital affiliated to
Mashhad University of Medical Sciences, Mahhad, Iran. SLE and RA activity indices were measured
and recorded. Furthemore, soluble isoforms, including shed HLA-G1 and HLA-G5, were
measured in serum samples via the ELISA method.

Results:
A comparison of the five groups showed no significant differences in the serum level of
sHLA-G. However, sHLA-G serum level was significantly higher in SLE and RA patients compared
to healthy controls (P<0.05). sHLA-G level showed no correlation with disease duration and
activity in SLE and RA patients (P>0.05). However, a strong positive correlation was observed between
the serum level of sHLA-G and 24-h urine protein in the previously diagnosed SLE group
(r=0.83, P=0.01).

Conclusion:
It seems that the serum level of sHLA-G is higher in RA and SLE patients compared
to healthy controls. Furthermore, a strong correlation was found between sHLA-G serum levels and
24-h urine protein in cases with a previous diagnosis of SLE.
Emerging Role of miRNAs in the Pathogenesis of Periodontitis
Authors: Taheri Mohammad , Khoshbakht Tayyebeh , Hussen Bashdar Mahmud , Abdullah Sara Tharwat , Ghafouri-Fard Soudeh , Sayad Arezou 
Published: June 2022

Abstract:
MicroRNAs (miRNAs) have been found to participate in the pathogenesis of several
immune-related conditions through the modulation of the expression of cytokine coding genes and
other molecules that affect the activity of the immune system. Periodontitis is an example of these
conditions associated with the dysregulation of several miRNAs. Several miRNAs such as let-7
family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30
and miR-21 have been shown to be dysregulated in patients with periodontitis. miR-146 is the most
assessed miRNA in these patients, which is up-regulated in most studies in patients with periodontitis.
In the present review, we describe the impact of miRNAs dysregulation on the pathoetiology of
periodontitis.
SpBLRSR: Schatten p-norm Constrained Bounded Low-rank Subspace
Recovery for Predicting N7-methylguanosine (m7G)-disease Associations
Authors: Ma Jiani , Zhang Lin , Chen Xiangzhi , Liu Hui 
Published: June 2022

Background:
As an essential positively charged RNA modification, N7-methylguanosine (m7G) has been reported to be associated with multiple diseases including cancers. While transcriptome-wide m7G sites have been identified by high-throughput sequencing approaches, the disease-associated m7G sites are still largely unknown. Therefore, computational methods are urgently needed to predict potential m7G-disease associations, which is crucial for understanding the biosynthetic pathways of tumorigenesis at the epi-transcriptome layer.

Objective:
We hope to develop an effective computational method that can accurately predict the associations between m7G sites and diseases, and then to prioritizing candidate m7G sites for novel diseases.

Method:
In this article, we proposed a Schatten p-norm constrained bounded low-rank subspace recovery (SpBLRSR) method for m7G-disease association prediction. An m7G-disease block matrix was built to alleviate the sparseness during the association pattern discovery process. By incorporating the low-rank representation (LRR) model and sparse subspace clustering (SSC) model, SpBLRSR was designed to capture both the global and local structures of the association pattern.

Results:
Compared with the benchmark methods, SpBLRSR achieved the
best performance in predicting associations between m7G sites and disease, and in prioritizing m7G sites for novel diseases. Then the robustness of Schatten p-norm in our method was further validated via a noise contamination experiment. Finally, case study of breast cancer was performed to elucidate the biological meaning of our method.

Conclusion:
SpBLRSR exploits the disease pathogenesis at the epitranscriptome layer by predicting potential m7A sites for disease.
Impact of COVID-19 on Brain and Psychological Health, its Possible Mechanisms, and Coping Strategies
Authors: Simnani Faizan Zarreen , Singh Dibyangshee , Choudhury Anmol , Akhtar Ansab 
Published: June 2022

Abstracts:COVID-19 pandemic has been depicted to possess a robust association with psychological disorders. SARS-CoV-2 is the most recent virus of the coronavirus family and has the potential to bind the angiotensin-converting enzyme (ACE) receptor. The receptor is mainly present peripherally and to some extent in the brain. Different psychological and neurodegenerative disorders can arise due to the peripheral origin of destruction. These triggers could be inflammatory pathways releasing pro-inflammatory cytokines reaching the brain and causing neuroinflammation. In continuation with traditional viruses, SARS-CoV-2 too might lead to brain diseases like meningitis, encephalitis, etc. Besides, several peripheral hormonal changes like cortisol can influence neurochemical alterations, thereby inflicting mood-related activities and psychological phenomena. In this regard, health care workers, frontline line warriors and relatives of COVID-19 patients can be the secondary victims; however, patients with COVID-19 remain the primary ones prone to neurological health problems. Several strategies like socialization, engagement, physical activity, etc., are well-opted measures to get relief from and check psychiatric disturbances. The worth of this review can be attributed to the understanding of brain-related mechanisms of COVID-19 in the context of its mechanism of action to create the pathology pertaining to brain disorder, precisely psychological devastation. Likewise, its epidemiological relevance has concisely been mentioned. Furthermore, different categories and classes of people prone to psychological deterioration are briefly elaborated on. Lastly, some coping strategies and approaches have been discussed to minimize or combat mental health problems.
The TP53 Gene and COVID-19 Virus: A Correlation Analysis
Authors: Anand C. Lakshmi , Namboori P.K. Krishnan 
Published: June 2022

Aim:
This study aimed to discover the most effective anti-cancer medicine for cancer patients
infected with SARS-CoV-2.

Background:
The correlation between TP53 and SARS-CoV-2 was examined using biomolecular
networking analysis.

Objective:
Cancer patients with TP53 gene mutations are more likely to be infected with the SARSCoV-
2 virus since it is the most frequently mutated tumor suppressor gene in human cancer. The main
goal of this study is to discover the most effective and efficient anti-cancer therapy for patients with
SARS-CoV-2 infection.

Materials and Methods:
Topp gene analysis was used to prioritize candidate genes based on molecular
function, biological process, and pathway analysis. Biomolecular networking was carried out using
Cytoscape 2.8.2. The protein-protein interaction network was used to identify the functionally associated
proteins. The protein-drug interaction network was used to observe the molecular therapeutic efficiency
of drugs. The network was further analyzed using CytoHubba to find the hub nodes. The molecular
docking was used to study the protein-ligand interaction, and the protein-ligand complex was
further evaluated through molecular dynamic simulation to determine its stability.

Results:
Functionally relevant genes were prioritized through Toppgene analysis. Using Cytohabba, it
was found that the genes UBE2N, BRCA1, BARD1, TP53, and DPP4 had a high degree and centrality
score. The drugs 5-fluorouracil, Methotrexate, Temozolomide, Favipiravir, and Levofloxacin have a
substantial association with the hub protein, according to protein-drug interaction analysis. Finally, a
docking study revealed that 5-fluorouracil has the highest connection value and stability compared to
Methotrexate, Favipiravir, and Levofloxacin.

Conclusion:
The biomolecular networking study was used to discover the link between TP53 and SARSCoV-
2, and it was found that 5-fluorouracil had a higher affinity for binding to TP53 and its related
genes, such as UBE2N, BRCA1, RARD1, and SARS-CoV-2 specific DPP4. For cancer patients with
TP53 gene mutations and Covid-19 infection, this treatment is determined to be the most effective.
Effect of Curcumin on Oxidative Stress, Inflammatory Response and
Kidney Biochemical Parameters Among Kidney Disease Patients: A
Systematic Review
Authors: Emami Elham , Talebi-Boroujeni Parham , Sherwin Catherine M.T. , Heidari-Soureshjani Saeid , Mohammadi Somayeh 
Published: June 2022

Background:
Chronic kidney disease (CKD) and end-stage renal diseases have high
global morbidity and mortality.

Objective:
We aimed to investigate the antioxidant and anti-inflammatory properties of curcumin
and its impact on kidney biochemical parameters associated with kidney disease among CKD and
hemodialysis (HD) patients.

Methods:
The intended keywords were used in the literature search. Clinical trial studies from the
beginning to December 25th, 2021, indexed in the Institute for Scientific Information (ISI),
Scopus, and PubMed databases, were included in the review. Records with no accessible full texts,
non-English language articles, and studies that were not related to the study aim were excluded.
The agreement for exclusion required all authors to concur. Finally, after reviewing all available
literature, 27 articles were included in this systematic review.

Results:
Curcumin supplementation increased antioxidant capacity by improving catalase (CAT)
activity, free radical scavenging activity, and nuclear factor erythroid 2–related factor 2 (Nrf2). It
also reduced hs-CRP, IL-6, and TNF-a levels in patients with CKD and HD patients. Different
results were reported regarding the effect of curcumin on kidney-related biochemical parameters.
But mostly, the results showed that no significant changes were seen in glomerular filtration
(GFR), albumin (Alb), serum creatinine (sCr), proteinuria (PRO), and blood urea nitrogen (BUN)
in these patients.

Conclusion:
Although it seems curcumin improved antioxidant capacity and decreased inflammatory
cytokines in CKD and HD patients, it did not affect renal biochemical parameters. More clinical
studies with larger sample sizes appear to be needed.