bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical application of skin antisepsis using aqueous olanexidine: a scoping review
Authors: Shinzato Yutaro , Sakihara Eiryu , Kishihara Yuki , Kashiura Masahiro , Yasuda Hideto , Moriya Takashi 
Published: January 2022

AbstractSurgical site infections (SSIs) and catheter‐related bloodstream infections (CRBSIs) caused by bacteria from surfaces poorly disinfected with chlorhexidine gluconate (CHG) and povidone‐iodine (PVP‐I) are increasing. Olanexidine gluconate (OLG) was developed in 2015 in Japan to prevent SSI and CRBSI caused by bacteria resistant to CHG and PVP‐I. This scoping review aimed to identify the knowledge gap between what is known and what is not known about the disinfection efficacy of OLG. We searched MEDLINE through PubMed, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the International Clinical Trials Registry Platform search database, ClinicalTrials.gov, and the Web‐based database of Japanese medical articles for works published to July 18, 2021. Manual reference searches were also carried out. A total of 131 studies were screened. Forty‐seven studies were included in this review and classified into two major categories: studies on pharmacological effects and spectrum (n = 29) and studies on clinical and adverse effects (n = 18). Olanexidine gluconate showed bactericidal activity against methicillin‐resistant Staphylococcus aureus and vancomycin‐resistant enterococci, in addition to common Gram‐positive and Gram‐negative bacteria. In clinical settings, although there is limited evidence on SSI prevention, 1.5% OLG might be more effective than 10% PVP‐I and 1% CHG in preventing SSI. However, the clinical usefulness of OLG is unclear due to the limited number of clinical studies. Also, clinical research is limited to studies targeting SSI prevention, and there are no clinical studies on CRBSI. Further clinical studies are needed on SSI and CRBSI prevention.
Shell‐like Xenon Nano‐Traps within Angular Anion‐Pillared Layered Porous Materials for Boosting Xe/Kr Separation
Authors: Zheng Fang , Guo Lidong , Chen Rundao , Chen Lihang , Zhang Zhiguo , Yang Qiwei , Yang Yiwen , Su Baogen , Ren Qilong , Bao Zongbi 
Published: January 2022

AbstractAdsorptive separation of xenon (Xe) and krypton (Kr) is a promising technique but remains a daunting challenge since they are atomic gases without dipole or quadruple moments. Herein we report a strategy for fabricating angular anion‐pillared materials featuring shell‐like Xe nano‐traps, which provide a cooperative effect conferred by the pore confinement and multiple specific interactions. The perfect permanent pore channel (4–5 Å) of Ni(4‐DPDS)2MO4 (M=Cr, Mo, W) can host Xe atoms efficiently even at ultra‐low concentration (400 ppm Xe), showing the second‐highest selectivity of 30.2 in Ni(4‐DPDS)2WO4 and excellent Xe adsorption capacity in Ni(4‐DPDS)2CrO4 (15.0 mmol kg−1). Crystallography studies and DFT‐D calculations revealed the energy favorable binding sites and angular anions enable the synergism between optimal pore size and polar porosity for boosting Xe affinity. Dynamic breakthrough experiments demonstrated three MOFs as efficient adsorbents for Xe/Kr separation.
Poly(acrylic acid)/polypyrrole interpenetrated network as electro‐responsive hydrogel for biomedical applications
Authors: Milani Giorgio Marques , Coutinho Isabela Trindade , Ambrosio Felipe Nogueira , Monteiro do Nascimento Mônica Helena , Lombello Christiane Bertachini , Venancio Everaldo Carlos , Champeau Mathilde 
Published: January 2022

AbstractThe combination of conducting polymers and hydrogels in a conductive interpenetrated polymer network (CIPN) is an interesting strategy to mimic muscles and to create bending actuators. Whereas the conducting polymer ensures the electro pulse flux, the hydrogel provides structural support similar to human tissues. In this work, poly(acrylic acid) (PAA) and polypyrrole (PPy) CIPNs were synthesized in aqueous solution in three different compositions and characterized in terms of their morphology, composition, mechanical, and electrochemical properties, as well as cytotoxic and the bending behavior when submitted to an electric field. Fourier transform infrared spectroscopy indicated hydrogen interaction between PAA and PPy, and PPy doping level was not modified when polymerized inside the PAA structure. Mechanical properties and density were shown to increase with an increase in PPy content, whereas water content decreased. Surprisingly, PAA/PPy CINPs presented some toxicity that may be due to the sterilization technique. Finally, PAA/PPy CIPNs responded mechanically to electrical stimuli and good curve symmetry and reversibility were observed in the cyclic voltammogram tests. These results indicate that the CIPN containing a PAA/PPy ratio of 1:0.3 is promising to prepare biocompatible soft bending actuators such as artificial muscles.
Fabrication of water‐resistant, thermally stable, and antibacterial fibers through in situ multivalent crosslinking
Authors: Wang Reuben , Jovanska Lavernchy , Tsai Yu‐Ting , Yeh Ying‐Yu , Yeh Yi‐Cheun 
Published: January 2022

AbstractFibers are emerging materials for biomedical applications, including drug delivery, sensing, tissue engineering, and wound dressing. However, fibers produced from water‐soluble polymers usually lose their morphology and quickly dissolve after exposure to water. Here, we developed a combined strategy of using multivalent crosslinkers along with in situ crosslinking to synthesize water‐resistant and thermally stable hybrid fibers. In our design, polyvinyl alcohol (PVA), aldehyde‐modified polyxylitol sebacate‐co‐polyethylene glycol (Ald_PXS‐co‐PEG, APP), and neomycin (Neo) were mixed to fabricate hybrid fibers through electrospinning. Several crosslinking chemistries were occurred in the hybrid fibers of PVA/APP/Neo, including the acetal bonds between PVA and APP, imine bonds between APP and Neo, and hydrogen bonds between PVA, APP, and Neo. These multiple chemical bonds allowed the PVA/APP/Neo fibers to maintain their fiber morphology after the immersion in the PBS solution, preserving the advantages of fibers (e.g., large surface‐to‐volume ratio and porosity) for applications in aqueous media. Particularly, the presence of Neo also provided the hybrid fibers with antimicrobial ability. Taken together, the in situ multivalent crosslinking has been demonstrated as a promising strategy to prepare stable and functional fibers for advanced applications.
Laccase: Various types and applications
Authors: Khatami Seyyed Hossein , Vakili Omid , Movahedpour Ahmad , Ghesmati Zeinab , Ghasemi Hassan , Taheri‐Anganeh Mortaza 
Published: January 2022

AbstractLaccase belongs to the polyphenol oxidase family and is very important in removing environmental pollutants due to its structural and functional properties. Recently, the ability of laccase to oxidize phenolic and nonphenolic substances has been considered by many researchers. This enzyme's application scope includes a broad range of chemical processes and industrial usages, such as bioremediation, nanobiotechnology, woodworking industries, bleaching of paper pulp, dyeing in the textile industry, biotechnological uses in food industries, biorefining, detoxification from wastewater, production of organic matter from phenolic and amine substrates, and biofuels. Although filamentous fungi produce large amounts of laccase, high‐yield industrial‐scale production of laccase is still faced with many problems. At present, researchers are trying to increase the efficiency and productivity and reduce the final price of laccase by finding suitable microorganisms and improving the process of production and purification of laccase. This article reviews the introduction of laccase, its properties, production processes, and the effect of various factors on the enzyme's stability and activity, and some of its applications in various industries.
Influence of piperine and omeprazole on the regional absorption of Daclatasvir from rabbit intestine
Authors: Ashmawy Shimaa M. , Eltahan Dina A. , Osman Mohamed A. , Essa Ebtessam A. 
Published: January 2022

AbstractThe study assessed the site dependent intestinal absorption of Daclatasvir and investigated the effects of piperine and omeprazole on such absorption utilizing in situ rabbit intestinal perfusion technique. The intestinal absorption of Daclatasvir was assessed in four segments: duodenum, jejunum, ileum, and colon. The effect of co‐perfusion with omeprazole was monitored through the tested anatomical sites. The effect of piperine, a P‐glycoprotein (P‐gp) inhibitor on Daclatasvir absorption from jejunum and ileum was tested. The results showed that Daclatasvir was incompletely absorbed from the rabbit small and large intestine. The absorptive clearance per unit length (PeA/L) was site dependent and was ranked as colon > duodenum > jejunum > ileum. This rank is the opposite of the rank of P‐gp intestinal content suggesting possible influence for P‐gp. Co‐perfusion with omeprazole increased PeA/L and this was evidenced also with reduced the L95% of Daclatasvir from both small and large intestinal segments. Significant enhancement in Daclatasvir absorption through jejunum and ileum was shown in presence of piperine. Daclatasvir showed site dependent intestinal absorption in a manner suggesting its affection by P‐gp efflux. This effect was inhibited by piperine. Co‐administration of Daclatasvir with omeprazole can enhance intestinal absorption a phenomenon which requires extension to human pharmacokinetic investigation.
Characterization of structural and optical properties of Mn2+‐doped Zn2GeO4 nanorods as an efficient green phosphor for solid‐state lighting
Authors: Lan Nguyen Mai Cao Hoang Phuong , Van Huan Pham , Thong Nguyen Huu , Nguyen Duy‐Hung , Kien Nguyen Duc Trung , Nhuong Chu Manh , Thang Cao Xuan , Pham Vuong‐Hung 
Published: January 2022

AbstractA series of Mn2+‐doped zinc germinate ZGO:xMn2+ (x = 0–0.05) nanorods was synthesized successfully using a hydrothermal method. XRD revealed that crystal phases of the ZGO:xMn2+ were rhombohedral and in the R‐3 space group. The Williamson–Hall equation was also used to explain the strain, nanocrystalline size, and stacking fault. Green LEDs were successfully fabricated by coating ZGO:Mn2+ nanorods onto UV‐LED chips. For high color purity, CIE of the fabricated green LEDs were (0.2404, 0.5428), which made this material a promising candidate for fabrication of UV‐based green LEDs.
A reversed‐phase ultra‐fast liquid chromatography–photodiode array detector (RP‐UFLC‐PDA) method for simultaneous estimation of ayapanin and umbelliferone in Ayapana triplinervis Vahl
Authors: Biswas Sayan , Kar Amit , Chanda Joydeb , Sharma Nanaocha , Bharadwaj Pardeep Kumar , Haldar Pallab Kanti , Mukherjee Pulok Kumar 
Published: January 2022

AbstractA rapid validated ultra‐fast liquid chromatography–photodiode array detector (UFLC‐PDA) method was developed to identify and quantify ayapanin (AY) and umbelliferone (UM) simultaneously in Ayapana triplinervis Vahl methanolic extract. The method was validated for linearity, limit of detection (LOD; 3:1σ/S), limit of quantification (LOQ; 10:1σ/S), precision, accuracy, specificity and robustness. The response was linear with a good correlation between concentration and mean peak area through a correlation coefficient of 0.9996, y = 7025.7x – 2269.8 and 0.9997, y = y = 16,262x – 946 with LOD of 6.256 ± 0.52 and 3.325 ± 0.36, and LOQ of 18.838 ± 0.18 and 8.870 ± 0.85 for AY (0.67% w/w) and UM (0.18% w/w), respectively. The relative standard deviation (%) of precision and recovery of AY and UM was <2.0%. The proposed method was simple, accurate, specific, precise and reproducible.
Simultaneous determination of eight analytes of Fuzheng Huayu recipe in beagle dog plasma by UHPLC–Q/exactive Orbitrap HRMS and its application to toxicokinetics
Authors: Wang Yu‐Lin , Yang Ming‐jv , Li Rong‐sheng , Hu Ye‐qing , Pan Yi‐feng , Yang Tao 
Published: January 2022

AbstractFuzheng Huayu recipe (FZHY) is a Chinese patent medicine for the treatment of liver fibrosis. This study aimed to investigate the toxicokinetics of FZHY in beagle dogs after oral administration. Blood samples were collected on days 1, 15 and 28 after oral gavage of FZHY dosages of 400 or 1,200 mg/kg body weight once a day. A UHPLC–Q‐Orbitrap method was developed and validated to simultaneously determine and quantify eight components of FZHY in beagle dog plasma. The times to peak concentration for eight components were18–120 min. The peak concentrations (Cmax) of amygdalin, genistein, daidzein and 3,4‐dihydroxybenzaldehyde were 1.43–43.50 ng/ml, the areas under the concentration–time curve (AUC(0–t)) were 2.45–6,098.25 ng min/ml, and the apparent volumes of distribution (Vd) were 0.05–131.23 × 104 ml/kg. The values of Cmax of prunasin, schisantherin A, schisandrin A and schisandrin were 7.35–1,450.73 ng/ml, the values of AUC(0–t) were 3,642.30–330,388.65 ng min/ml, and the values of Vd were 11.15–1,087.18 × 104 ml/kg. No obvious accumulation of the eight compounds was observed in beagle dogs. The results showed that the method is rapid, accurate and sensitive, and is suitable for detecting the eight analytes of FZHY. This study provides an important basis for the assessment of FZHY safety.
Industry 4.0 technologies and circular economy: The mediating role of supply chain integration
Authors: Di Maria Eleonora , De Marchi Valentina , Galeazzo Ambra 
Published: January 2022

AbstractThere is a great expectation that Industry 4.0 technologies will enable better circular economy (CE) results at firms. However, it is unclear how these technologies might contribute to CE. We hypothesize that Industry 4.0 technologies are positively related to the level of integration among actors along the supply chain and within the firm supply chain integration (SCI), which, in turn, explains superior CE results. By employing partial least square structural equation models on original survey data based on a sample of more than 1200 Italian manufacturing firms and almost 200 adopters, we find that disentangling for the type of technologies is essential to understanding both their direct and indirect role toward CE. Smart manufacturing technologies have a stronger impact on CE outcomes than data processing technologies; the mediating effect of SCI is verified for the former but not for the latter type, questioning the possibility for those technologies to support sustained CE performance in the long run.
A Comparative DFT Study on the Antioxidant Activity of Some Novel 3‐Hydroxypyridine‐4‐One Derivatives
Authors: Dehkordi Mehrdad M. , Asgarshamsi Mohammad H. , Fassihi Afshin , Zborowski Krzysztof K. 
Published: January 2022

AbstractThe current study on the antioxidant activity of kojic acid and 3‐hydroxypyridine‐4‐one derivatives was performed by implementation of density functional theory calculations with the B3LYP hybrid functional and the 6‐311++G** basis set in Polarizable Continuum Model of solvation. Compounds under evaluation were previously synthesized by our research group. The DPPH scavenging effect and the IC50values in mM concentrations were evaluated. Subsequently, various electronic and energetic descriptors such as HOMO and LUMO energy gaps, bonding dissociation enthalpy of an OH bond, ionization potential, electron affinity, hardness, softness, NBOs and spin density of radical and neutral species were used to study antioxidant properties of investigated compounds. The computations detected two compounds,HP3andHP4, with significant antioxidant activity. Energetic descriptors indicated that the SPLET mechanism is preferred over the other antioxidation mechanism and computational results were in accordance with the experimental results.
Phenolics, Flavonoids Content and Antioxidant Activities of Tuber indicum at Different Maturity Stages
Authors: Li Yang , Liang Hanqiao , Zhou Dongyu , Xing Yongmei , Chen Juan 
Published: January 2022

AbstractThe Chinese black truffle Tuber indicum (Ascomycota, Pezizales) is an ectomycorrhizal fungus forming hypogeous edible ascocarps. As a famous wild edible mushroom in the world, this species also attracted an increasing interest in their chemical composition and pharmacological activity. In this study, the total phenolic content, total flavonoid content and antioxidant activities of Tuber indicum collected from July to November at different maturity stages in China were analyzed. Our results showed that T. indicum collected in July (immature stage) possessed the highest amount of flavonoids (3.89 mg/g dw) and the highest ABTS.+ scavenging activity (EC50=3.73 mg/ml). In addition, those samples collected in August (moderate mature stage) contained the highest phenolics content (4.78 mg/g dw), the highest DPPH⋅ radical scavenging activity (EC50=3.73 mg/ml) and ferric reducing activity power (243.63 μmol FeSO4/g). The study reveals T. indicum in the early maturity stage yield significantly higher content of phenolics and flavonoids and possessed stronger antioxidant activity than those collected in other months. This study provided important data for understanding the relationship between maturity stages and truffle formation and evaluating the quality of Chinese black truffle at different maturity.
Saringosterol Acetate Isolated fromSargassum fusiformisInduces Mitochondrial‐Mediated Apoptosis in MCF‐7 Breast Cancer Cells
Authors: Li Xue , Zhou Dong‐Yue , Li Fang‐Tong , Jiang Yun‐Fei , Dai Yu‐Lin , Jeon You‐Jin 
Published: January 2022

AbstractSargassum fusiformisis among the most important edible brown seaweeds in Eastern Asia that contains various bioactive compounds and strong activities. Saringosterol acetate (SA) was successfully isolated fromS. fusiformisin our previous research. In this study, SA was investigated for its anticancer effect on MCF‐7 breast cancer cells. SA attenuated the survival rate of MCF‐7 cells with an IC50value of 63.16±3.6 μg/mL. Staining with Hoechst 33342 demonstrated that SA treatment mediated apoptotic body generation. SA significantly downregulated Bcl‐xL and upregulated Bax, and cleaved PARP, and cleaved caspase 3 in a dose‐dependent manner. Thus, these results suggest that SA induced mitochondria‐mediated apoptosis in MCF‐7 cells, making it a plausible candidate for drug development against breast cancer.
New Efficient Synthesis of tRNA Related Adenosines Bearing the Hydantoin Ring (ct6A, ms2ct6A) by Intramolecular Cyclization of N6‐(N‐Boc‐α‐aminoacyl)‐adenosine Derivatives
Authors: Frankowska Katarzyna , Sochacka Elzbieta 
Published: January 2022

AbstractA novel and efficient way for the synthesis of N6‐hydantoin‐modified adenosines, which utilizes readily available N6‐(N‐Boc‐α‐aminoacyl)‐adenosine derivatives, was developed. The procedure is based on the epimerization‐free, Tf2O‐mediated conversion of the Boc group into an isocyanate moiety, followed by intramolecular cyclization. Using this method two recently discovered hydantoin modified tRNA adenosines, that is, cyclic N6‐threonylcarbamoyl‐adenosine (ct6A) and 2‐methylthio‐N6‐threonylcarbamoyladenosine (ms2ct6A) were prepared in good yields.
Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1‐JAK2 positive myeloid sarcoma and acute B‐lymphoblastic leukemia
Authors: Rizzuto Giuliana , Leoncin Matteo , Imbergamo Silvia , Taurino Daniela , Mico Maria Caterina , Tosi Manuela , Michelato Anna , Buklijas Ksenija , Spinelli Orietta , Lussana Federico , Lessi Federica , Pizzi Marco , Bonaldi Laura , Binotto Gianni , Rambaldi Alessandro , Gurrieri Carmela 
Published: January 2022

AbstractThe translocation t(8;9)(p22;p24) results in the production of a chimeric PCM1‐JAK2 fusion protein leading to the constitutive activation of the Janus Kinase 2 that renders this disease potentially sensitive to ruxolitinib. Here, we report an interesting case of PCM1‐JAK2 myeloproliferative neoplasm evolving in myeloid sarcoma and B precursor ALL.
Anion gap‐opening metabolic acidosis and urinary findings in the early diagnosis of ethylene glycol poisoning: A case report
Authors: Ukita Kentaro , Otomune Kanako , Fujimoto Ryo , Hasegawa Kanako , Izumikawa Koichi , Morimoto Nobutoshi , Sasaki Kazuhiro , Hirasaki Akihito , Takaguchi Koichi 
Published: January 2022

AbstractCausative agent identification is important in the treatment of poisoning. We report the case of a patient who presented with an altered level of consciousness after drinking a fluorescent pink liquid. Upon measuring the anion gap and urinary calcium oxalate level, the patient was diagnosed with early ethylene glycol poisoning.
Bart's syndrome associated with a disorder of sexual differentiation: An atypical presentation in a Cameroonian newborn
Authors: Sigha Odette Berline , Mbono Betoko Ritha , Nkoro Grace Anita , Fossi Happi Mireille , Ekoube Charlotte Eposse , Kelbaba Benjamin Bertrand , Mandeng Ma Linwa Edgar , Kouotou Emmanuel Armand 
Published: January 2022

AbstractBart's syndrome consists of congenital aplasia of the skin affecting only the lower limbs, associated with bullae over the skin and/or mucous membranes, as well as a nail anomaly. It is an extremely rare genetic disorder, which can be associated with other birth defects. We report the case of a newborn baby admitted at day 0 of life in the neonatal department, for multifocal skin detachment predominantly at the lower limbs. In addition, examination of the external genitalia revealed a clitoridomegaly genital bud measuring 14 mm, scrotalized and unfused genital bulges with the presence of 2 orifices. No gonad was palpated. The clinical diagnosis of Bart's syndrome associated with a disorder of sexual differentiation was retained. We hereby report the first case of Bart's syndrome described in Cameroon in association with a disorder of sexual differentiation.
Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report
Authors: IbnIdris Rodwan Amel Awad , A. Mohammed Abdel Gaffar. , Adam Essa Mohammed Elmujtba , Abdalla Babker Atif Elhadi , Mohamed Abdelsatir Ali , Mohammed Elagib Elnour 
Published: January 2022

AbstractRheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by symmetric and destructive polyarthritis with a broad‐spectrum clinical manifestation of various organs. RND is an unusual distinctive manifestation of RA and typically develops in severe RA. This report aims to present an unusual and a rare neutrophilic skin condition, in a seronegative RA Sudanese patient. A 51‐year‐old woman was diagnosed with RA three years ago and a history of bilateral polyarthritis, presented with a skin rash involving her extremities and abdomen. Clinical examination of her skin revealed the presence of maculopapular lesions affecting the extensor surfaces of the lower extremities and the lower part of the abdomen with hyperpigmentation. Hand X‐ray demonstrated periarticular osteopenia, and laboratory and immunological studies that include C‐reactive protein, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anticitrullinated peptide antibodies (ACPAs), and antinuclear factor in addition to skin biopsy were all suggested a diagnosis of neutrophilic dermatosis. The patient received steroids for the skin lesion still no significant improvement was seen, and then, cyclosporin 100 mg was administrated twice/ day with close monitoring, and two weeks later marked improvement was shown.
The submental flap: Be wary
Authors: Shires Courtney B. , Sebelik Merry 
Published: January 2022

AbstractThe submental island flap (SIF) is as an alternative to free flaps in head and neck reconstruction. 10 patients underwent submental flaps. All ten patients suffered failure of SIF as the definitive reconstructive procedure. Despite comparing favorably to free tissue transfer in published reports, our SIF had high failure rate.