bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of IL36RN and CARD14 mutations with clinical manifestations and laboratory findings in patients with generalised pustular psoriasis
Authors: Trai Nguyen Ngoc , Van Em Dang , Van Bui Thi , My Le Huyen , Van Tro Chau , Hao Nguyen Trong , Vu Hoang Anh , Tram Duong Bich , Van Thuong Nguyen , Doanh Le Huu 
Published: September 2022

Background
Generalized pustular psoriasis (GPP) is a chronic disease associated with genetic factors related to mutations of the interleukin 36 receptor antagonist gene (IL36RN) and the caspase recruitment domain 14 gene (CARD14). However, the relevance of these mutations to the clinical features and severity of GPP remains unclear.

Aims
Our objective was to correlate the presence of IL36RN and CARD14 mutations with the clinical and laboratory findings in patients with GPP.

Methods
This cross-sectional descriptive study was conducted in 64 subjects with GPP. Clinical manifestations were recorded and the severity was graded as mild, moderate, or severe. Routine laboratory tests were performed and blood samples were collected for Sanger sequencing. The clinical data of patients were compared among the different mutation groups.

Results
The two main variants of IL36RN were c.115+6T > C (p.Arg10ArgfsX1) and c.227C > T (p.Pro76Leu). The major CARD14 mutations were c.2458C > T (p.Arg820Trp), c.1641C > T (p.Arg547Ser), and c.1753G > A transitions.
Provocative factors were uncommon in the group with both IL36RN and CARD14 mutations. Drugs (unspecified), especially herbals, were the most common triggers. A history of psoriasis was frequent in patients with only CARD14 mutations, but fever was uncommon. The c.1641C > T mutation was associated with leukocytosis > 15000/mm3 and the c.1753G > A mutation was associated with hypoalbuminemia <3.8g/dL.
Both the c.115+6T > C and c.227C > T variants of IL36RN were associated with fever ≥38.5°C while the c.115+6T > C variant was also associated with geographic tongue.
No gene mutations were associated with the total severity and severity grades.

Limitations
Four patients without the two major IL36RN mutations were excluded from the study.

Conclusion
The presence of IL36RN and CARD14 mutations were associated with a history of psoriasis, various provocative factors, fever, leukocytosis, hypoalbuminemia, and geographic tongue. Further studies to explore the role of these mutations in therapeutic efficacy and disease outcomes are necessary.
The crux of helix curvature: A potential surface landmark for the anterior border of the sigmoid sinus in minimally invasive presigmoid approaches
Authors: Hoz Samer S. , Palmisciano Paolo , Algburi Hagar A. , Sharma Mayur , Ismail Mustafa , Andaluz Norberto 
Published: September 2022

Background:
Surgical landmarks are widely used across all surgical specialties to assist surgeons in accurately estimating the deep anatomical structures. We describe the crus of helix curvature as a potential indicator for the anterior border of the sigmoid sinus (SS) in the setting of minimally invasive presigmoid approaches.

Methods:
Anatomy investigations were performed on injected cadaveric heads to identify consistent surface surgical landmarks estimating the curse of the SS.

Results:
Presigmoid mastoid was noted in the center of the skin incision in 100% of the specimens. The crus of helix curvature was superimposed on the anterior border of the SS on 6 sides (60%). On the other four sides, the curvature lays within 5 mm of the anterior SS border (40%).

Conclusion:
For the minimally invasive presigmoid approaches, the “crus of helix curvature” can be used as a landmark for the anterior border of the SS, which can aid in the speed and safety of the procedure. The ease of use of this landmark makes it particularly convenient for physicians early in training.
ОРГАНИЗАЦИОННО-ФИНАНСОВЫЕ МОДЕЛИ, ИНСТРУМЕНТАРИИ И РИСКИ В РЕАЛИЗАЦИИ ПРОЕКТОВ ГОСУДАРСТВЕННО-ЧАСТНОГО ПАРТНЕРСТВА
Authors: Меджидов Заур Уруджалиевич 
Published: September 2022

Привлечение частных инвестиций к решению социальных и экономических проблем – важная задача любого государства. Реализация инфраструктурных проектов вкупе с выполнением социальных и экономических программ позволяет государству вести компактную, эффективную и гибкую политику. Цель исследования. Проанализировать организационно-финансовые модели государственно-частного партнерства, используемые в отечественной и зарубежной практике, а также исследовать инструментарии государственно-частного партнерства и риски в реализации проектов государственно-частного партнерства. Методология исследования основана на корректном использовании методов анализа и синтеза, а также систематизации и сравнения. Результаты. Проанализированы основные организационно-финансовые модели и риски, возможные при реализации проектов государственно-частного партнерства, инструментарии и институты развития государственно-частного партнерства. Выводы. Введение санкций со стороны ряда зарубежных стран, направленных на блокирование активов в международной юрисдикции и запрет на сделки для физических и юридических лиц иностранных государств. Подобная ситуация требует от институтов развития усилить содействие в реализации новых стратегических проектов с ориентиром на отечественное предпринимательское сообщество, а от государства – интенсификации усилий по налаживанию деятельности и повышению эффективности всех государственных структур.
Abordaje paliativo domiciliario: Delirium refractario en demencia de Creutzfeldt-Jakob. Reporte de caso
Authors: Erazo María Marcela , Vallejo Daniel Eudoro , Molina Sandra Milena 
Published: September 2022

Introducción: La enfermedad Creutzfeld-Jakob, es una rara entidad neurodegenerativa, es la forma más común de enfermedades por priones reconocida en humanos, compromete el área cortical del cerebro, más específicamente la corteza de los lóbulos frontales, parietales, temporales y el hipocampo; tiene un curso rápidamente progresivo de naturaleza incurable. Su baja prevalencia en la población general dificulta llegar a un diagnóstico certero y precoz, que pueda llevar al equipo médico a entablar un plan de manejo interdisciplinario que mejore la calidad de vida de estos pacientes y su familia; es frecuente la aparición de síntomas de difícil control entre ellos el delirium que deteriora física y emocionalmente al paciente, sus seres queridos y cuidadores. Presentación del caso: Paciente de 60 años con de enfermedad por priones quien cursó con cuadro de deterioro cognitivo, intolerancia a la vía oral, desnutrición, deshidratación, delirium, mioclonías e insomnio; presentando delirium de etiología multifactorial, de muy difícil control, requiriendo manejo con neurolépticos atípicos y típicos, alcanzando la dosis máxima terapéutica sin un adecuado control, ante la refractariedad fue necesario manejo con sedación paliativa, logrando control sintomático y fallecimiento en domicilio. Conclusiones: Ante casos de demencia de Creutzfeld-Jakob con sintomatología de difícil control, en particular ante delirium refractario la sedación paliativa es una opción de manejo que puede realizarse en domicilio por un equipo entrenado, logrando adecuados resultados.
ЗБАГАЧЕННЯ СПЕЛЬТОВОГО ХЛІБА НЕНАСИЧЕНИМИ ЖИРНИМИ КИСЛОТАМИ
Authors: Науменко Оксана , Полонська Тетяна , Радзієвська Ірина , Богдан Галина , Гетьман Інна , Бокова Світлана 
Published: September 2022

Метою роботи є збагачення спельтового хліба ненасиченими жирними кислотами для створення повноцінного збалансованого продукту щоденного харчування з урахуванням біологічних властивостей метаболізму в організмі. Методи дослідження. Дослідження кінетики модельного окиснення рослинних олій різного ступеня ненасиченості (соняшникової, гірчичної, кунжутної, купажованої) проведено за пероксидним числом (ПЧ), стандартним методом індикаторного титрування. Експеримент з окиснення досліджуваних олій проведено за температури 200°С при вільному доступі повітря. Процес контролювали за величиною ПЧ до досягнення 10 ммоль1/2О/кг. Для лабораторного випікання хліба використовували безопарний спосіб у дві стадії закваска-тісто. При цьому способі одразу замішували тісто за допомогою лабораторної тістомісильної машини. Тістові заготовки формували вручну. Після бродіння, поділу сформовані тістові заготовки вистоювали у термостаті за температури (38 ± 2)°С і відносної вологості (78 ± 2)%. Результати досліджень. Досліджено гірчичну, кунжутну олії та їх суміш у співвідношенні 50/50. Аналіз співвідношень ɷ-3 / ɷ-6 / ɷ-9 ненасичених кислот показав, що склад індивідуальних олій не відповідає вимогам біологічного балансу жирнокислотного складу. У зв’язку з цим нами запропоновано використання купажованої гірчично-кунжутної 50/50 олії, розрахунковий жирнокислотний склад якої задовольняє вимозі збалансованого жиру. Зокрема, співвідношення С18:2ɷ6 : С18:1ɷ9 становить 1:1,73 проти рекомендованого 1:1,8; а співвідношення 18:3ɷ3 : 18:2ɷ6 ‒ 1:4,80 проти рекомендованого 1:5. Встановлено, що купажована гірчично-кунжутна олія є найбільш стабільною у порівнянні з рештою олій. Значення її пероксидного числа зросло на 2,8 ммоль1/2О/кг, швидкість окиснення купажованої олії становить 0,048, що є нижчою швидкістю окиснення від решти зразків. Висновок. На підставі отриманих досліджень була розроблена та затверджена нормативна документація для виробництва хліба «Спельтовий ароматний».
Overview of Higher Education in the 21st Century
Authors: Kumar Suman , Pandey D.C. 
Published: September 2022

No nation gets world-class topper status in higher education overnight. Investment made in the field of education proves its significance or futility after one and a half to two decades. In the contemporary Indian scenario, higher education is shifting away from quality to being market-oriented. The imprecision which is seen in it results in a shift from the traditional pass to the state-of-the-art. It doesn't seem to fit our needs. The level of human resources that are expected to be created from higher education is completely lacking in practical life in our country. Following the policies of Lord Macaulay Mahaprabhu, our education system is sowing the seeds of inequality instead of social harmony. Ignoring the national needs and requirements, our higher education society cannot be relative without the air planners getting acquainted with the ground reality. Where is the adoption of higher education policies of developed nations in societies without basic infrastructure, leading us blindly, social governments can be established in higher education by connecting modern global ideas with traditional knowledge. In this country full of diversities, it is possible to implement a perspective higher education policy. The need is strong willpower. By keeping higher education away from appeasement and political ambivalence, it can be saved from being frivolous.
Education is the backbone of human civilization. Education is the foundation of civilization and culture. Education is the most effective means of all-round development and transformation of human beings. From ancient times, education in Indian society was broad, knowledge-oriented, well-planned, and well-organized. Through education, our lives are not only refined, refined and refined, pure, intelligent and advanced, but by following the sattvik and moral values-directives of the entire society, human welfare is achieved. Perhaps that is why education is declared as an important parameter of development. Higher education works to strengthen any society and nation within the world. Higher Education Objectives To acquire knowledge or to earn money, in the Indian context, whether higher education is deviating from its original objectives, the seeds of the present form of the Indian education system can be traced in the mirror of the British rule that ruled for almost two hundred years. If it is to be said that the present entire education system is a gift of the British Raj, then there will be no exaggeration. Charles Grant, who is called the father of this education system.01 what they must have imagined in this present distorted form is well known that the British used education in their own interest. They planned to create a new educated class in India who could conduct their colonial rule according to their vision plan. The goal of English education in the early stages was to nurture the roots of the British government while spreading Christianity in India.
Controlled Release Floating Matrix Tablet of Captopril
Authors: N. Abed Haithem , A. Abdulrasool Alaa , M. Ghareeb Mowafaq 
Published: September 2022

The present study was done to prepare a gastroretentive floating tablet of captopril (CAP) which is an angiotensin converting enzyme inhibitor (ACE-inhibitor) used in the treatment of hypertension and heart failure. CAP is mainly absorbed from the proximal intestine and to a lesser extent from the stomach, also CAP stability decreases as the pH raised above 1.2 and this makes it a suitable candidate for floating dosage form.Effervescent floating tablets of CAP were prepared in order to prolong the gastric residence time and increase the bioavailability of the drug. The floating tablets of CAP were prepared by direct compression and wet granulation technique, using the polymer hydroxypropylmethylcellulose (HPMC) as the primary retarding polymer together with carboxymethylcellulose(CMC) ,ethyl cellulose(EC) and pectin as a secondary release modifying polymers in different ratios of (1:1, 3:1 and 9:1). Different formulation parameters were studied such as type of diluents, amount of effervescent agent, methods of preparation and their effects on buoyancy and the in vitro drug release profile as well as their physical characteristics. The wet granulation method shows a good flow and compressibility characteristics and a better dose uniformity in comparison with direct compression technique. Pectin together with HPMC in the ratio of 1:1 was found to meet the requirement for a good matrix formation and floating characteristics and the drug release was sufficiently sustained for 12 h with floating time >24h and floating lag time of 2 min. Kinetic modeling of the release data for the selected formula showed that the mechanism of drug release pattern follows anomalous or non â€“fickian diffusion.
Key words: Captopril, floating, matrix tablet, pectin.
Effect of Administration of Crystalloid IV Fluids Preoperatively on Postoperative Pain
Authors: M. Al-Nema Zeena , I. Mohammed Samer , T. Ahmed Fadia 
Published: September 2022

Pain is a sensory and emotional experience that is influenced by physiologic, sensory, affective, cognitive, socio-cultural and behavioral factors. Postoperative pain is the commonest reason for delayed discharge and unanticipated hospital admission after ambulatory surgery. Our Objective is to test the hypothesis that administration of 2 ml/kg/hr preoperative IV fluids may attenuates postoperative pain.The study was carried out in the Baghdad Teaching Hospital, Al-Yarmok Teaching Hospital and Al-Karama Teaching Hospital from 12 May till 17 June 2009. The total number of patients was 120 (35 males and 85 females) with their age ranged between 10-90 years. The patients were divided into two groups according to administration of preoperative IV fluids, group A (65 patients) did not receive IV fluids and group B (55 patients) received IV fluids preoperatively. Regarding group A, the pain scale was â‰¤ 5 in 15.3% of patients, and it was >5 in 84.7% of patients and these results obtained within 0-5 hours after awaking from anesthesia. Whereas in group B, the pain scale was â‰¤5 in 29.09% of patients and was >5 in 70.9% of patients. We have demonstrated that the preoperative administration of 2ml/kg/hr IV fluids (crystalloid) to patients who had fasted from fluids decreased the severity of postoperative pain, and the need for postoperative analgesia. We report for the first time that administration of large volume preoperative IV fluids significantly reduce the incidence and severity of pain in patients at high risk for pain.
Key words: I.V fluids, Pain, Surgery.
Nitric Oxide, Peroxynitrite and Malondialdehyde Levels as Markers for Nitrosative/Oxidative Stress in Iraqi Patients with Systemic Lupus Erythematosus
Authors: M. Mohammed Shaimaa , A. Amin Inaam , Z. Sabri Zeina 
Published: September 2022

Systemic lupus Erythematosus is an autoimmune disease of unknown aetiology affecting multiple organ system. Reactive nitrogen and oxygen species are claimed to play a role in this disease. However, the potential of Nitrosative/Oxidative Stress to elicit an autoimmune, response remain till now largely unexplored in humans. This study was done to investigate the status and contribution of nitrosative/oxidative stress in Iraqi patients for systemic lupus erythematosus. Blood samples from 19 patients with systemic lupus erythematosus and 19 age-and sex- matched apparently healthy controls were evaluated for serum levels of nitrosative/oxidative stress markers including nitric oxide, peroxynitrite and malondialdehyde. Nitric oxide levels were measured by spectrophetometric method depending on Griss method, while peroxynitrite levels were measured by spectrophetometric method based on peroxynitrite mediated nitration of phenol. Malondialdehyde levels were measured by the thiobarbitoric acid method. Serum nitric oxide levels were significantly elevated in SLE patients (mean + SE 263.58 + 35.42 mmol/L) as compared with healthy control (162.48 +10.42 mmol/L). Peroxynitrite levels were also significantly elevated in a disease group (mean + SE 7.23 +0.92 mmol/L) as compared to healthy control (4.47 + 0.38 mmol/L). On the other hand, malondialdehyde levels were slightly elevated in SLE patient (mean + SE 4.53 + 0.22 nmol/ml) as compared to control group (4.32 + 0.58nmol/ml). The study findings support an association between nitrosative/oxidative stress and SLE through elevated level of NO, peroxynitrite and MDA in the serum of SLE patients.
Key words: Nitric oxide, Peroxynitrite, SLE.
Effect of Different Diluent and Binder Types on the Preparation of Bisoprolol Fumarate as Tablet Dosage Form
Authors: A. Fatohy Heba , A. Abdul-Rasool Alaa 
Published: September 2022

Hypertension is one of the main causes of heart disease; beta- blockers play a crucial role in the management of patients with essential hypertension. Bisoprolol is one of the widely used drugs for the treatment of hypertension. Bisoprolol tablets were prepared by two methods (direct and wet) using different proportion and types of diluents, different binder types and forms, then evaluated for, weight variation, hardness, friability, disintegration time and dissolution rate. The results were compared with a reference Bisoprolol tablet.
Both methods of preparation wet and direct compression method gave good results, which are consistent with the requirements of British Pharmacopeia and United States Pharmacopeia. It was found that the type of diluent (mannitol and lactose), binder type (polyvinyl pyrrolidone and acacia) and the presence of starch as a disintegrant affect the hardness, disintegration and the dissolution rate of the tablet. While liquid binder (polyvinyl pyrrolidone solution) gave longer disintegration time (12 min) with higher hardness compared with the powdered binder (polyvinyl pyrrolidone powder) that gave (5 min).
The results indicate that formula F1 which consists of [Mannitol (65mg)/ Avicel 102 (26 mg), starch and magnesium stearate] showed the best results as it has lower disintegration time (2.7 min), faster dissolution rate (100% release within 20 min) and prepared by a low cost method (direct method).
Key words: Bisoprolol, diluent, binder, direct compression, wet granulation.
Response Surface Methodology for Development and Optimization of Theophylline Pulmonary Delivery System
Authors: A. Yas Ali , I. Khalil Yehia , S. Mohamed Mohamed 
Published: September 2022

The aim of the present study was to develop theophylline (TP) inhalable sustained delivery system by preparing solid lipid microparticles using glyceryl behenate (GB) and poloxamer 188 (PX) as a lipid carrier and a surfactant respectively. The method involves loading TP nanoparticles into the lipid using high shear homogenization â€“ ultrasonication technique followed by lyophilization. The compositional variations and interactions were evaluated using response surface methodology, a Box â€“ Behnken design of experiment (DOE). The DOE constructed using TP (X1), GB (X2) and PX (X3) levels as independent factors. Responses measured were the entrapment efficiency (% EE) (Y1), mass median aerodynamic diameter (MMAD, daer) (Y2), zeta potential (ZP, Î¾) (Y3), fine particles fraction (% FPF) (Y4) and percentage of dissolution efficiency at 420 minutes (% DE420) (Y5). The optimized formula was characterized by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X â€“ ray powder diffraction (XRD) demonstrated that prolonged release physically due to the loaded TP exists mostly in its crystalline state . Analysis of dissolution data of the optimized formula indicated that the best fitting is with Higuchi model, whereas the mechanism of drug release pattern follows anomalous or non â€“ Fickian diffusion.
Key words: Glyceryl behenate, solid lipid microparticles, theophylline nanoparticles
The Relationship between ABO Blood Group Distribution and the incidence of Upper Gastric and Duodenal Ulcer in Iraqi Patients
Authors: K. Abdulridha Manal 
Published: September 2022

The relationship between blood group antigens and peptic ulcer disease has been widely evaluated in the past, but only one study relating H pylori seroprevalence to ABO blood groups among Iraqi patients with peptic ulcer disease is available. We aimed to evaluate the frequency of peptic ulcer disease among different ABO blood groups in Iraqi patients, and we thought it was worthwhile to try to determine whether these components take some part in disease etiology. One hundred and six patients with peptic ulcer disease (PUD) (43 male and 63 female; mean age: 48 Â± 18 years) who attended Baghdad teaching hospital and Al- Yarmouk teaching hospital endoscopy centers were enrolled , and 238 control Subjects. Finger blood samples were used for ABO/Rhesus (Rh) blood group antigen typing. The ABO blood group phenotype frequency in peptic ulcer patients was as follows: 18.9% for blood group A, 15.1% for blood group B, 57.5 % for blood group O and 8.5% for blood group AB. Rh positivity was found in 100% of patients. Significant higher percentage of patients with both gastric and duodenal ulcer disease are those holding blood group O+ compared to other blood group phenotypes (57.5%)( p= 0.003) .The present study show higher incidence of doudenal ulcer( DU) in patients with blood group O+ compared to gastric ulcer( GU) patients (65.6%vs 54.1%) , although no statistical difference between both diseases was found,( p Ëƒ 0.05) in respect to other blood group phenotypes. Peptic ulcer disease is predominant in patients aged between 50-59 years represents with higher percentage (26.4%) compared to other age groups. Patients with blood group O+ phenotype presented with a highly significant percentage of Peptic ulcer disease, since those individuals may express a higher inflammatory responses to H. pylori with higher levels of lymphocyte infiltration in the gastrointestinal mucosa , and a higher frequency of secretor status . In addition, they do not produce the substance on the surface of blood group O+ cells that may protect the lining of the duodenum .According to these results, probably ABO/Rh blood group (mainly blood group O+) has an important role in patients with peptic ulcer disease as additional risk . The functional significance of ABO blood group distribution might be associated with biological behavior of Peptic ulcer disease. The impact of blood group on Peptic ulcer disease may be a focus for further studies.
Keywords: ABO/ Rh Blood group system - Upper gastrointestinal disorders â€“Age & Gender distribution