bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between High Density Lipoprotein Level With Degree Of Stenosis In Coronary Artery Disease
Authors: Pratama Arrizki Azka , Abduh Saugi , Zulaikhah Siti Thomas 
Published: April 2022

Coronary Artery Disease (CAD) can be prevented by early detection and control of risk factors. This study aimed to determine the relationship of High Density Lipoprotein (HDL) levels with stenosis levels based on Significant Non-Significant angiography in CAD patients. Observational research method with cross-sectional design from secondary data at RSI Sultan Agung Semarang in January 2016 - October 2018, 363 respondents met the inclusion and exclusion criteria. Data were analyzed by Spearman test and logistic regression. In low HDL, significant stenosis was found to be 80.5% and non-significant 19.5%, significant HDL was found with significant stenosis 67.0% and non-significant 33.0%, whereas in high HDL, all (100%) with significant stenosis. The results with the Spearman test obtained p = 0.022. In the multivariate analysis of sex as the predominant variable (p=0,000; PR=4.743; 95%CI=1.496-4.109). age (p = 0.013; PR = 3.48; 95% CI = 1.24- 6.13), hypertension (p = 0.044; PR = 1.79; 95% CI = 1.10-3.17). There was a significant relationship between HDL levels and significant stenosis levels based on significant non-angiography in CAD patients and after being analyzed together with the disrupting variables as sex the most influential factors.
ANALYSIS OF QUALITY CONTROL OF T-SHIRT SCREEN PRINTING PRODUCTS WITH SIX SIGMA DMAIC METHOD ON CV. MACCA CLOTHING.
Authors: Rauf Nurhayati , Padhil Ahmad , Alisyahbana Takdir , Saleh Anis , Dahlan Muhammad 
Published: April 2022

CV. Macca Clothing is a company engaged in Clothing screen printing. The resulting product is a short sleeve t-shirt screen printing. In producing the production, on average per month there are defective products of 6% types of defects, namely blurred colors, wrong colors, and wrong screen printing. Therefore, this study aims to providelevels sigma and DPMOand then analyze the factors causing disability and provide suggestions for improvements to reduce defective products at CVMacca Clothing. The data collection method used is to conduct interviews with CV.Macca Clothing. Then in analyzing the data using the method DMAIC and theapproach six sigma.From the research results, thevalue DPMO is 21,000 and the conversion result is 3.53, which means that out of a million opportunities there will be 3.53 possibilities for the production process to produce defective products. in thelevel stage sigma CV.Macca Clothing has not yet reached thelevel Six Sigma, but it is still in the average industrial condition because in the production process there are still product defects that have not reached zero defect. The factors that cause defects in the product are the operator is not careful in doing the work, the quality of raw materials is not good, the cleanliness of the equipment is not maintained, and the production room facilities are inadequate. From the results of the analysis based on the implementation tools kaizen , the control and improvement to reduce defects that must be carried out by CV.Macca Clothing is to carry out stricter supervision or control, carry out regular machine maintenance, and provide complete facilities.
Tetrathienothiophene Porphyrin as a Metal-Free Sensitizer for Room-Temperature Triplet–Triplet Annihilation Upconversion
Authors: Vasilev Aleksey , Kostadinov Anton , Kandinska Meglena , Landfester Katharina , Baluschev Stanislav 
Published: April 2022

Optically excited triplet states of organic molecules serve as an energy pool for the subsequent processes, either photon energy downhill, such as room temperature phosphorescence, or photon energy uphill process—the triplet–triplet annihilation upconversion (TTA-UC). Manifestation of a high intersystem crossing coefficient is an unavoidable requirement for triplet state formation, following the absorption of a single photon. This requirement is even more inevitable if the excitation light is non-coherent, with moderate intensity and extremely low spectral power density, when compared with the light parameters of 1 Sun (1.5 AM). Coordination of a heavy atom increases substantially the probability of intersystem crossing. Nevertheless, having in mind the global shortage in precious and rare-earth metals, identification of metal-free organic moieties able to form triplet states becomes a prerequisite for environmental friendly optoelectronic technologies. This motivates us to synthesize a metal-free thienothiophene containing porphyrin, based on a condensation reaction between thienothiophene-2-carbaldehyde and pyrrole in an acidic medium by modified synthetic protocol. The upconversion couple tetrathienothiophene porphyrin/rubrene when excited at λ = 658 nm demonstrates bright, delayed fluorescence with a maximum emission at λ = 555 nm. This verifies our hypothesis that the ISC coefficient in thienothiophene porphyrin is efficient in order to create even at room temperature and low-intensity optical excitation densely populated organic triplet ensemble and is suitable for photon energy uphill processes, which makes this type of metal-free sensitizers even more important for optoelectronic applications.
Development and Validation of a Prediction Model for Cardiovascular Events in Exercise Assessment of Coronary Heart Disease Patients After Percutaneous Coronary Intervention
Authors: Shen Tao , Ren Chuan , Zhao Wei , Tao Liyuan , Xu Shunlin , Zhang Chengduo , Gao Wei 
Published: April 2022

ObjectiveThis study aimed to develop a model for predicting cardiovascular events in the exercise assessment of patients with coronary heart disease after percutaneous coronary intervention (PCI) based on multidimensional clinical information.MethodsA total of 2,455 post-PCI patients who underwent cardiopulmonary exercise testing (CPET) at the Peking University Third Hospital from January 2016 to September 2019 were retrospectively included in this study; 1,449 post-PCI patients from January 2018 to September 2019 were assigned as the development cohort; and 1,006 post-PCI patients from January 2016 to December 2017 were assigned as the validation cohort. Clinical data of patients before testing and various indicators in the exercise assessment were collected. CPET-related cardiovascular events were also collected, including new-onset angina pectoris, frequent premature ventricular contractions, ventricular tachycardia, atrial tachycardia, and bundle branch block during the examination. A nomogram model for predicting CPET-related cardiovascular events was further developed and validated.ResultsIn the development cohort, the mean age of 1,449 post-PCI patients was 60.7 ± 10.1 years. CPET-related cardiovascular events occurred in 43 cases (2.9%) without fatal events. CPET-related cardiovascular events were independently associated with age, glycosylated hemoglobin, systolic velocity of mitral annulus, ΔVO2/ΔWR slope inflection, and VE/VCO2 slope &gt; 30. The C-index of the nomogram model for predicting CPET-related cardiovascular events was 0.830, and the area under the ROC curve was 0.830 (95% CI: 0.764–0.896). For the validation cohort of 1,006 patients, the area under the ROC curve was 0.807 (95% CI: 0.737–0.877).ConclusionPost-PCI patients with older age, unsatisfactory blood glucose control, impaired left ventricular systolic function, oxygen uptake parameter trajectory inflection, and poor ventilation efficiency have a higher risk of cardiovascular events in exercise assessment. The nomogram prediction model performs well in predicting cardiovascular events in the exercise assessment of post-PCI patients and can provide an individualized plan for exercise risk prediction.
Rapid Exhumation Processes of the Gaoligong Mountain Range in the Southeastern Margin of the Qinghai–Tibet Plateau Since the Late Cenozoic
Authors: Wang Jialong , Li Ni , Stuart F. M. , Nicola L. D. , Zhang Huiping , Wang Ying , Pang Jianzhang , Zhao Yongwei 
Published: April 2022

Three continent-scale ductile shear zones trending N-S are distributed in the southeast margin of the Qinghai–Tibet Plateau. Their tectonic deformation and exhumation histories are of great significance to understanding the orogenic processes within the continent and the growth as well as expansion mechanism of the plateau. The Gaoligong shear zone (GLGSZ) is the westernmost zone near the boundary of the Indian subduction plate and is less well studied than the Ailaoshan–Red River shear zone (ASRRSZ) in the east. In this study, low-temperature thermochronological methods including apatite (U-Th)/He (AHe), zircon (U-Th)/He (ZHe), and apatite fission track (AFT) were used to date the vertical profile samples from the Gaoligong Mountain to understand the exhumation processes that occurred in the late Cenozoic. Our results show that the GLGSZ has experienced two stages of rapid exhumation events since the late Cenozoic: in the middle Miocene (∼14.5 Ma) and early Pleistocene (∼2.9 Ma). Based on our data, we divided the late Cenozoic tectonic deformation and exhumation processes in the Gaoligong Mountain area into two stages: 1) From the middle to the late Miocene, large-scale regional dextral strike-slip movements and lateral compressions controlled the ductile shear zone and continuously denuded the mountain surface; 2) in the Pleistocene, rapid river erosion and undercutting caused by fluctuations of the monsoon system, together with the continuous activity of brittle faults, drove the latest rapid exhumations. A comparison of the thermochronological data of the different areas along the Gaoligong Mountain shows that the exhumation rate in its northern transect is significantly higher and the time of the onset of exhumation is earlier than that in the southern transect. These results indicate that the deformation processes began in the north and continued southwards and controlled the geomorphological characteristics of the Gaoligong Mountain, whose elevation is higher in the northern part than in the southern part.
A Polygenic Score for Type 2 Diabetes Improves Risk Stratification Beyond Current Clinical Screening Factors in an Ancestrally Diverse Sample
Authors: Ashenhurst James R. , Sazonova Olga V. , Svrchek Olivia , Detweiler Stacey , Kita Ryosuke , Babalola Liz , McIntyre Matthew , Aslibekyan Stella , Fontanillas Pierre , Shringarpure Suyash ,   23andMe Research Team, Pollard Jeffrey D. , Koelsch Bertram L. 
Published: April 2022

A substantial proportion of the adult United States population with type 2 diabetes (T2D) are undiagnosed, calling into question the comprehensiveness of current screening practices, which primarily rely on age, family history, and body mass index (BMI). We hypothesized that a polygenic score (PGS) may serve as a complementary tool to identify high-risk individuals. The T2D polygenic score maintained predictive utility after adjusting for family history and combining genetics with family history led to even more improved disease risk prediction. We observed that the PGS was meaningfully related to age of onset with implications for screening practices: there was a linear and statistically significant relationship between the PGS and T2D onset (−1.3 years per standard deviation of the PGS). Evaluation of U.S. Preventive Task Force and a simplified version of American Diabetes Association screening guidelines showed that addition of a screening criterion for those above the 90th percentile of the PGS provided a small increase the sensitivity of the screening algorithm. Among T2D-negative individuals, the T2D PGS was associated with prediabetes, where each standard deviation increase of the PGS was associated with a 23% increase in the odds of prediabetes diagnosis. Additionally, each standard deviation increase in the PGS corresponded to a 43% increase in the odds of incident T2D at one-year follow-up. Using complications and forms of clinical intervention (i.e., lifestyle modification, metformin treatment, or insulin treatment) as proxies for advanced illness we also found statistically significant associations between the T2D PGS and insulin treatment and diabetic neuropathy. Importantly, we were able to replicate many findings in a Hispanic/Latino cohort from our database, highlighting the value of the T2D PGS as a clinical tool for individuals with ancestry other than European. In this group, the T2D PGS provided additional disease risk information beyond that offered by traditional screening methodologies. The T2D PGS also had predictive value for the age of onset and for prediabetes among T2D-negative Hispanic/Latino participants. These findings strengthen the notion that a T2D PGS could play a role in the clinical setting across multiple ancestries, potentially improving T2D screening practices, risk stratification, and disease management.
Multi-Omics Analysis of the Prognosis and Biological Function for TRPV Channel Family in Clear Cell Renal Cell Carcinoma
Authors: Jiang Yuxiong , Han Dongxu , Zhao Yifan , Zhang Chen , Shi Xiujuan , Gu Wenyu 
Published: April 2022

BackgroundThe transient receptor potential vanilloid (TRPV) channels family, TRPV1-6, has been identified to profoundly affect a wide spectrum of pathological processes in various cancers. However, the biological function and prognostic value of TRPVs in clear cell renal cell carcinoma (ccRCC) are still largely unknown.MethodsWe obtained the gene expression data and clinical information of 539 ccRCC patients from The Cancer Genome Atlas (TCGA) database. A series of databases were used for data processing and visualization, including GEPIA, GeneMANIA, MethSurv, GSCA, TIMER, and starBase databases.ResultsThe mRNA expression of TRPV2/3 was upregulated while the expression of TRPV5/6 was downregulated in ccRCC tumor tissues. TRPV family members in ccRCC were rarely mutated (nearly 7 frequencies). The ROC curve showed that TRPV2/5/6 had a high diagnostic ability in discriminating ccRCC from the control samples (AUC&gt;0.9). Higher levels of TRPV3 expression were associated with poor prognosis of ccRCC patients, while higher expression of TRPV4 was associated with favorable prognosis. The expression of TRPV3 in normal and ccRCC tissues was validated by Immunohistochemistry, and its expression was remarkably related to high histologic grade and advanced stage. Besides, TRPV3 exhibit a reduction of DNA methylation level with tumor progression, and 12 CpGs of TRPV3 were associated with a significant prognosis. In addition, TRPV3 expression was significantly associated with the accumulation of several tumor-infiltrating immune cells, especially regulatory T cells. Furthermore, high levels of TRPV3 induced the expression of immune checkpoints such as LAG3, CTLA4, PDCD1, and TIGIT. Finally, we predicted a key SNHG3/AL513497.1-miR-10b-5p-TRPV3 axis linking to carcinogenesis and progression of ccRCC.ConclusionOur study may uncover TRPV channels–associated molecular mechanisms involved in the tumorigenesis and progression of ccRCC. TRPV family members might be diagnosed and prognostic markers and potential therapeutic targets for ccRCC patients.
Case Report: Invasive Cryptococcosis in French Guiana: Immune and Genetic Investigation in Six Non-HIV Patients
Authors: Goupil de Bouillé Jeanne , Epelboin Loïc , Henaff Fanny , Migaud Mélanie , Abboud Philippe , Blanchet Denis , Aznar Christine , Djossou Felix , Lortholary Olivier , Elenga Narcisse , Puel Anne , Lanternier Fanny , Demar Magalie 
Published: April 2022

ObjectivesWe describe the clinical, mycological, immunological, and genetic characteristics of six HIV-negative patients presenting with invasive cryptococcosis.MethodsPatients with cryptococcosis without any of the classical risk factors, such as HIV infection, followed at Cayenne Hospital, were prospectively included. An immunologic and genetic assessment was performed.ResultsFive male patients and one female patient, 5 adults and one child, were investigated. All presented a neuromeningeal localization.Cryptococcus neoformansvar.gattiiandC. neoformansvar.grubiiwere isolated in two and three patients, respectively, whereas one patient could not be investigated. Overall, we did not observe any global leukocyte defect. Two patients were found with high levels of circulating autoantibodies against Granulocyte macrophage-colony stimulating factor (GM-CSF), and none had detectable levels of autoantibodies against Interferon gamma (IFN-γ) Sequencing ofSTAT1exons and flanking regions performed for four patients was wild type.ConclusionTo better understand cryptococcosis in patients with cryptococcosis but otherwise healthy, further explorations are needed with repeated immune checkups and strain virulence studies.
The Beat Goes On: Humpback Whale Song Seasonality in Antarctic and South African Waters
Authors: Shabangu Fannie W. , Kowarski Katie A. 
Published: April 2022

Little is known of the movements and seasonal occurrence of humpback whales (Megaptera novaeangliae) of South Africa and the Antarctic, populations once brought to near extinction by historic commercial whaling. We investigated the seasonal occurrence and diel-vocalizing pattern of humpback whale songs off the west coast of South Africa (migration route and opportunistic feeding ground) and the Maud Rise, Antarctica (feeding ground), using passive acoustic monitoring data collected between early 2014 and early 2017. Data were collected using acoustic autonomous recorders deployed 200-300 m below the sea surface in waters 855, 1,118 and 4,400 m deep. Acoustic data were manually analyzed for humpback whale vocalizations. While non-song calls were never identified, humpback whale songs were detected from June through December in South African waters, with a peak in percentage of acoustic occurrence around September/October in the austral spring. In Antarctic waters, songs were detected from March through May and in July (with a peak occurrence in April) where acoustic occurrence of humpback whales was negatively correlated to distance to the sea ice extent. Humpback whales were more vocally active at night than in the day at all recording sites. Detection range modelling indicates that humpback whale vocalizations could be detected as far as 18 and 45 km from recorders in South African and Antarctic waters, respectively. This study provides a multi-year description of the offshore acoustic occurrence of humpback whales off the west coast of South Africa and Maud Rise, Antarctica, regions that should continue to be monitored to understand these recovering populations.
Comparison of the Effectiveness of Various Drug Interventions to Prevent Etomidate-Induced Myoclonus: A Bayesian Network Meta-Analysis
Authors: Zhang Kang-Da , Wang Lin-Yu , Zhang Dan-Xu , Zhang Zhi-Hua , Wang Huan-Liang 
Published: April 2022

BackgroundMyoclonic movement is a very common but undesirable phenomenon during the induction of general anesthesia using etomidate. Such movement may cause unnecessary problems. Currently, there is an increasing number of drugs for preventing etomidate-induced myoclonus (EM). However, direct comparisons of various drugs are lacking, and this interferes with clinical decision-making. Our network meta-analysis (NMA) aimed to compare the efficacy of different drugs for the prevention of moderate-to-severe general myoclonus.MethodsUsing several biomedical databases, randomized controlled trials (RCTs) published in English from inception to August 22, 2021 were searched. Among the various interventions, we selected nine types of intervention drugs (dexmedetomidine, etomidate, lidocaine, NMDA receptor antagonist, κ opioid receptor agonist, μ opioid receptor agonist, muscle relaxant, gabapentin, and midazolam) for comparison, according to the number of studies. Bayesian NMA was performed using STATA16 and R softwares. The relative risk of EM was assessed using risk ratios (RRs) and the corresponding 95% confidence intervals (CI).ResultsA total of 31 RCTs (3209 patients) were included. NMA results showed that, compared with a placebo, etomidate (RR 4.0, 95%CI 2.1–7.8), κ opioid receptor agonist (RR 2.9, 95%CI 1.9–4.6), μ opioid receptor agonist (RR 3.1, 95%CI 2.3–4.3), NMDA receptor antagonist (RR 1.7, 95%CI 1.0–2.8), dexmedetomidine (RR 2.4, 95%CI 1.5–3.9), lidocaine (RR 2.1, 95%CI 1.2–3.9), and midazolam (RR 2.2, 95%CI 1.5–3.2) can significantly reduce the risk of EM. In contrast, the effects of muscle relaxants (RR 2.1, 95%CI 0.81–5.3) and gabapentin (RR 2.8, 95%CI 0.92–9.3) were inconclusive. Further subgroup analyses showed that preoperative low-dose etomidate, μ-opioid receptor agonist, and κ-opioid receptor agonist were significantly better than other interventions in the prevention of moderate to severe EM.ConclusionPreoperative use of small doses of etomidate or opioids may be the most effective way to avoid EM, especially moderate and severe EM, which makes anesthesia induction safer, more stable, and aligns better with the requirements of comfortable medicine.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/], [CRD4202127706].
Research Trends and Hotspots on Herpes Zoster: A 10-Year Bibliometric Analysis (2012–2021)
Authors: Zhang Jian , Han Xu , Su Diansan , Gu Xiyao , Yu Weifeng 
Published: April 2022

PurposeHerpes zoster infection, with its considerable burden to individuals and society, remains a challenge around the world. However, to the knowledge of the authors, little bibliometric quantitative or qualitative analysis has been carried out to evaluate herpes zoster research. This study aimed to use a bibliometric analysis to evaluate current publication trends and hotspots on herpes zoster research worldwide, in order to advance research in this field.MethodsRelevant publications from January 2012 to December 2021 were collected from the Web of Science Core Collection database. Citespace (V5.8.R3) was used to analyze the research points, including publication countries, institutions and authors, cited author, cited reference and their clustering, and keyword co-occurrence, and burst keyword to acquire research trends and hotspots.ResultsA total of 9,259 publications were obtained, with a steady increase in the number of annual publications during the decade. Articles were the main type of publication. The United States is the leading country in this research, and the University of Colorado has the highest influence in this field. Oxman is the most representative author, with a main research interest in herpes zoster vaccines. The top five cited authors' publications focused on herpes zoster vaccines, molecular mechanisms, and postherpetic neuralgia. A co-citation map resulted 19 main clusters, and revealed that vaccines, postherpetic neuralgia, treatments, varicella zoster virus and its mechanisms, and epidemiology of herpes zoster were the current research focus after clustering co-cited publications. Human herpesviruses, antiviral prophylaxis, rheumatoid arthritis, recombinant zoster vaccine, varicella vaccination and postherpetic neuralgia were the top clusters after co-occurrence keywords analysis. Moreover, burst keywords detection showed that the subunit vaccine was the new hotspot in the field of herpes zoster.ConclusionThis bibliometric study defined the overall prospects in the field of herpes zoster and provided valuable instruction for the ongoing research. The keyword “subunit vaccine” indicated that a vaccine for herpes zoster prevention was the hotspot. Efforts to prevent varicella zoster virus infection will be essential to improve herpes zoster outcomes.