bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a qualitative data analysis codebook informed by the i-PARIHS framework
Authors: Ritchie Mona J , Drummond Karen L. , Smith Brandy N. , Sullivan Jennifer L. , Landes Sara J. 
Published: September 2022

Abstract
Background: The integrated-Promoting Action on Research Implementation in Health Services (i-PARIHS) framework, and its predecessor PARIHS, have been widely utilized in implementations studies. Although i-PARIHS developers have focused on creating tools to guide facilitators in its application in practice, tools are also needed for evaluation and research. Codebooks with clear and meaningful code labels and definitions are an important component of qualitative data analysis and have been developed for other widely used frameworks. There is no such codebook for i-PARIHS. Additionally, sub-constructs for the Innovation, Recipients, and Context constructs lack definitions and there is no sub-classification of facilitation activities for the Facilitation construct. The lack of a standardized codebook hinders our ability to synthesize research findings across studies, explore and test the range of activities that are utilized in facilitation efforts, and potentially validate and further refine i-PARIHS. This paper describes a rigorous process of developing a detailed qualitative codebook informed by the i-PARIHS framework.Methods: A workgroup of qualitative researchers conducted a rigorous four-phase process to develop a codebook informed by i-PARIHS. In phase 1, workgroup members reviewed and discussed literature, consulted an organizational scientist, and drafted and refined subcodes and definitions for i-PARIHS constructs. In phase 2, they obtained feedback from an expert panel and further refined subcodes and definitions. In phase 3, they obtained feedback from i-PARIHS developers/experts and incorporated it into the codebook. Finally, two studies piloted application of the codebook which informed the final version.Results: The resulting i-PARIHS-informed codebook includes definitions for the four main constructs of the framework: Innovation, Recipients, Context, and Facilitation; subcodes and definitions for characteristics of each of these constructs; and instructions for the suggested application of individual codes and use of the codebook generally.Conclusions: The standardized codes and definitions in the codebook can facilitate data exploration, pattern identification, and insight development informed by the i-PARIHS framework. Qualitative analysts can also use them to explore interactions between i-PARIHS constructs, maximize the potential for comparing findings across studies, and support the refinement of the i-PARIHS framework using empirical findings from multiple studies.
Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation in-vivo.
Authors: Wong Jeffrey , Kirberger Steven , Qiu Ryan , Ekanayake Arunika , Kelich Payam , Sarkar Susmita , Alvizo-Paez Edgar , Miao Jiayuan , Kalhor-Monfared Shiva , Dwyer John , Nuss John , Lin Yu-Shan , Macauley Matthew , Vukovic Lela , Pomerantz William , Derda Ratmir 
Published: September 2022

AbstractIn this paper, we report selection of albumin-binding macrocyclic peptides from genetically encoded libraries of peptides modified by perfluoroaryl-cysteine SNAr chemistry. Modification of phage-displayed libraries SXCXnC-phage,n = 3–5, where X is any amino acid except for cysteine by decafluoro-diphenylsulfone (DFS), yields genetically-encoded library of octafluoro-diphenylsulfone-crosslinked macrocycles (OFS-SXCXnC-phage). Selection from these libraries using albumin as a bait identified a family of significantly enriched perfluoroaryl-macrocycles. Synthesis of perfluoroaryl-macrocycles predicted by phage display and testing their binding properties by19F NMR and fluorescent polarization identifiedOFS-macrocycle with SICRFFC sequence as the most potent albumin binder. We observed thatOFS-macrocycles slowly react with biological nucleophiles such as glutathione. Replacing decafluoro-diphenylsulfone by nearly isosteric pentafluorophenyl sulfide yielded perfluorophenylsulfide (PFS)-crosslinked macrocycles devoid of undesired reactivity. The augmented leadPFS-macrocycle with SICRFFC sequence exhibitedKD= 4–6 µM towards human serum albumin and similar affinities towards rat and mouse albumins. When injected in mouse, thePFS-SICRFFCGGG compound was significantly retained in circulationin vivowhen compared to controlPFS-macrocyclic peptide. The perfluoroaryl-macrocycles with SICRFFC motif are the smallest known peptide macrocycle with significant affinity for human albumin and they are a productive starting point for future development of compact macrocycles with predictable circulation half-lifein vivo.
MosTI single-copy transgene insertion in C. elegans using constitutive Cas9 expression
Authors: Mouridi Sonia El , Frøkjær-Jensen Christian 
Published: September 2022

Abstract

Transgene expression in C. elegans is an important tool for understanding regulatory elements (e.g., promoters and enhancers), for controlling cells using optogenetic effector proteins, and for editing the (epi)genome. Insertion of single-copy transgenes into well-defined safe-harbor locations can be used when consistent expression is required (e.g., to compare expression from different transgenes) or when expression is required in germ cells. Here, we describe a detailed protocol for inserting single-copy transgenes using Modular Safe-harbor Transgene Insertion (MosTI) and constitutive Cas9 expression from a co-injected plasmid.
Quantum Hall-like effect in electrochemical systems due to extra-dimension embedded in 3D graphene at room temperature
Authors: Sric Chavis , Danvirutai Pobporn , Wisitsoraat Anurat , Tuantranont Adisorn 
Published: September 2022

Abstract
In this work, we report for the first time, the quantization effect occurred at room temperature in an electrochemical system. The setup where it occurred was electrodeposition of gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) onto three-dimensional microstructure graphene (GF) under certain applied potential. This is the first time that this quantum phenomenon occurs in solutions under electrochemical experiment. This effect might be described as quantum coherency in extra dimension embedded in three-dimensional microstructure of graphene foam which approximately hold radius around 100 µm. Possible explanation was proposed that the quantum effect occurs due to quantization in extra dimension when certain conditions were met. Our simplified quantum calculation could be used to fit with the experimental data. The quantization behaviors were observed in both silver and gold electrodeposition on GF. Primary theoretical description was explained in this article using Landauer formalism and Polyakov action from string theory. However, the concrete theoretical explanation could possibly be further elaborated or explained in a different way (Supplementary data contains the experimented videos).
Adaptive Unscented Kalman Filter for Neuronal State and Parameter Estimation
Authors: Azzalini Loïc J. , Crompton David , D'Eleuterio Gabriele M. T. , Skinner Frances , Lankarany Milad 
Published: September 2022

Abstract
Data assimilation techniques for state and parameter estimation are frequently applied in the context of computational neuroscience. In this work, we show how an adaptive variant of the unscented Kalman filter (UKF) performs on the tracking of a conductance-based neuron model. Unlike standard recursive filter implementations, the robust adaptive unscented Kalman filter (RAUKF) jointly estimates the states and parameters of the neuronal model while adjusting noise covariance matrices online based on innovation and residual information. We benchmark the adaptive filter's performance against existing nonlinear Kalman filters and explore the sensitivity of the filter parameters to the system being modelled. To evaluate the robustness of the proposed solution, we simulate practical settings that challenge tracking performance, such as a model mismatch and measurement faults. Compared to standard variants of the Kalman filter the adaptive variant implemented here is more accurate and robust to faults.
Root mass density is responsible for nitrogen use efficiency in wheat during the early vegetative stage in low nitrogen conditions
Authors: Zeng Jian , Hu Xigui , Zhang Kehao , Zhang Fanglin , Wang Yi , Kang Houyang , Lan Ting , Chen Guangdeng , Xu Lili , Zhou Yonghong 
Published: September 2022

Abstract
Crop nitrogen use efficiency (NUE) decreases as the N supply increases, leading to wasted resources. Genetic variations that alter root morphological traits may be useful for developing crops able to explore the deep soil strata to enhance their N acquisition and NUE. The objective of this study was to examine the relationship between root functional traits and NUE on the basis of a large set of wheat genotypes. A total of 126 genetically diverse wheat genotypes from major wheat-growing regions worldwide were grown for 2 months to compare root morphological traits, photosynthetic traits, biomass, N accumulation, and NUE under low N conditions. There were large genotypic variations in dry biomass accumulation, N accumulation, N concentration, and NUE in response to low N supply. An analysis of specific low N stress-induced phenotypic changes revealed the examined root morphological traits were closely associated with N accumulation, NUE, and biomass accumulation. A high root mass density (RMD) was conducive to improving NUE in response to the limited availability of N. Photosynthesis had little effect on NUE in wheat during the early stage under low N conditions. In wheat, compared with photosynthetic activities, root system development, especially in terms of RMD, has a greater effect on N acquisition and use for biomass production during the initial stage under low N conditions.
Supporting Single and Multi-Core Resource Access Protocols on Object-Oriented RTOSes
Authors: Santos Lucas Matheus dos , Gracioli Giovani , Kloda Tomasz , Caccamo Marco 
Published: September 2022

Abstract
Real-time resource access protocols are fundamental to bound the maximum delay a task can suffer due to priority inversions. Several real-time protocols have been proposed, for both static and dynamic scheduling approaches in single and multi-core processors. One of the main factors for performance efficiency in such protocols is the way they are implement within a real-time operating system (RTOS).
In this paper we present an object-oriented design of real-time access protocols considering single and multi-core systems and also suspension- and spin-based protocols (7 protocols in total). Our design aims at reducing the run-time overhead and increasingcode re-usability. By implementing the proposed design in an RTOS and running the protocols in a modern multi-core processor, we provide an analysis regarding the memory footprint, run-time overhead, and the impact of the overhead into the schedulability analysis of synthetically generated task sets. Our results indicate that proper implementation provides low run-time overhead (up to 6.1 us) and impact on the schedulability of real-time tasks.
Research on the Construction of Entrepreneurial Ecosystem and Its Effect on Entrepreneurial Enterprises Based on Process Perspective ——Case study of Hangzhou Dream Town
Authors: Xiang Yongsheng , Shi Linxia 
Published: September 2022

Abstract
By choosing Hangzhou Dream Town as the case study object, and analyzed the construction of entrepreneurial ecosystem(EE) and its effect on entrepreneurial enterprises, the study found that the Dream Town centered on entrepreneurs, and gradually carried out three-stage and three-layer town construction. That is, by attracting and exerting the roles of different entities such as the government, incubators, service organizations, and universities, forming a "five forces" power mechanism such as government power, service power, capital power, scientific and technological power, and ecological power, to gather basic resources for the Dream Town. The construction of the initial, mid and late stages of entrepreneurship platforms and entrepreneurial sustainable development has created the basic resource layer, platform service layer and innovation development layer from outside to inner for the growth and development of entrepreneurial incubations. The EE had accomplished the continuous improvement of entrepreneurial enterprises from the factor chain, service chain to industrial chain/innovation chain, and improved the success rate and growth of entrepreneurial incubations.
An optimization method of product function configuration based on value analysis
Authors: Yin Fupeng , Gao Qi , Sun Jiakun 
Published: September 2022

Abstract

Product function configuration is important for customer satisfaction and enterprise profitability. In this paper, we attempt to apply the value engineering theory to optimize the configuration scheme. The concepts of customer perceived benefit, enterprise perceived cost and product function configuration value are discussed. The evaluation method of value elements based on utility theory is proposed, to quantify the function configuration value. The value model perfectly integrates the interests of the customer and the enterprise. The product function configuration optimization model is established and used to optimize an automatic transmission product configuration scheme. This optimization model based on value analysis can realize the game equilibrium between the customer and the enterprise, which attaches importance to the subjective feelings of them.
Spatiotemporal Characterization of of the impact of Hurricane Michael on Urban Vegetation Cover in Panama City and Panama City Beach, Florida
Authors: Alam Asiful , Mishra Deepak R. , Dwivedi Puneet 
Published: September 2022

Abstract
The impacts of major climatic events on urban vegetation cover are not well understood. We used Landsat 8 ETM + derived land cover in Google Earth Engine (GEE) to determine damage to urban vegetation, and Optimized Hotspot and Outlier Analyses to identify significant spatial clusters of hotspots and cold spots from Hurricane Michael in Panama City and Panama City Beach, Florida. We used two vegetation indices (Normalized Difference Water Index-NDWI and Enhanced Vegetation Index-EVI) to assess the impact of Hurricane Michael on urban vegetation cover. Results show that more than 30.07% of the land cover changed after two months of the hurricane landfall, including a rapid increase of 19.64% in water bodies. Overall, we observed a 4.91% decrease in vegetation cover, out of which 34.44% were coastal woody wetlands. NDWI showed a rapid increase due to an increase in water coverage in the study area, whereas EVI decreased due to vegetation loss by strong winds and intense precipitation. After Hurricane Michael, hotspots for high water content in sustained vegetation (NDWI) and overall vegetation condition (EVI) were discovered in Panama City Beach, Southport, and Youngstown CCD (census county division). Statistically significant (≥ 95% confidence, z ≥ 1.96) increases in NDWI hotspots (76.11% of the total area) were observed post-hurricane due to an increase in water bodies. EVI showed a decrease of about 9.21% in hotspot areas (≥ 95% confidence, z ≥ 1.96) due to defoliation caused by hurricane force winds. Our results highlight the advantages of using spatial statistical methods that could aid the development of natural hazard mitigation plans and risk reduction strategies by characterizing urban vegetation status in the Gulf Coast from previous hurricane occurrences spatiotemporally.
Picosecond synchronously pumped diamond Raman laser
Authors: Shuanghong Ding , Xinxin Huang , Zou Qiaoshuang 
Published: September 2022

Abstract
With diamond crystals as Raman media, picosecond synchronously pumped solid-state Raman laser is theoretically studied in detail for the first time. High efficient working point and effective pulse compression working point are investigated. For both 532nm and 1064nm pumping, high Raman conversion efficiency can be achieved for negative cavity length detuning (Δx) and diamond crystal length of 5mm. The higher efficiency can be obtained with longer Raman crystal, longer pumping pulse width and higher pumping power. For 532nm pumping, effective pulse width compression can be realized for Δx = 0 nearby and diamond crystal length of 10mm. Shorter pulse width and higher peak power of 1st Stokes laser can achieved with longer Raman crystal, shorter pumping pulse width and higher pumping power. The findings can contribute to the design and optimization of picosecond synchronously pumped diamond Raman lasers.
Malaria Among Pregnant Women in, Bossaso City, Somalia: Cross Sectional Study Design
Authors: Jama Abdirahman , Mahamed Abdulahi Abdiwali , Assebe Tesfaye 
Published: September 2022

Abstract
Background: Malaria is a serious disease that leads to severe adverse effects on mothers and the fetus during pregnancy. Approximately 25 million pregnant women in sub-Saharan Africa live at risk of malaria. This study aims to address the prevalence of malaria and its associated factors among pregnant women in Bossaso, Somalia.Objective: To determine the prevalence of malaria and its associated factors among pregnant women in Bossaso city, Somalia.Methods: A health institution-based cross-sectional study was conducted among 422 pregnant women in Bossaso General Hospital (BGH) using an interview-administered questionnaire and malaria diagnosis confirmation, which was done on microscope-based laboratory techniques. The collected data were analyzed using Statistical Package for the Social Sciences (SPSS) version 25. Bivariate and multivariate logistic regression models were employed to identify factors associated with malaria. The level of statistical significance was declared at a p-value less than or equal to 0.05.Results: The overall prevalence of malaria was found 20.9% [95%CI (15.9%, 25.9%)]. Of these, 64 (75.3%), 19 (22.4%), and 2 (2.4%) were caused by Plasmodium falciparum, Plasmodium vivax, and mixed infection, respectively. The factors like the presence of water pond sites around the house or vicinity [AOR= 6.5, 95% CI (1.6, 20.5)] and always using insecticide-treated bed nets (ITNs) [AOR=0.1, 95%CI (0.01, 0.88)] were found to be significantly associated with malaria during pregnancy.Conclusion and Recommendation: Malaria is still a health problem among pregnant women in Bossaso city. The overall prevalence of malaria among pregnant women in the study area was found to be high. This study emphasized the need to provide health education and consultation to pregnant women on the appropriate malaria preventive methods and continued strengthening other interventions.
Incorporation of high band gap Carbon Nanotubes as Transparent Conductive Electrode in ITIC-OE accepter Organic solar cell
Authors: Sharma Bharti , Singh BP 
Published: September 2022

Abstract
The most common transparent conducting electrode, ITO, is delicate and prone to shattering under mechanical stress, which lowers the device's performance on flexible plastic substrates. Because of their exceptional optical transparency, low sheet resistance, and great mobility, carbon nanotubes have garnered a lot of interest as a Transparent Conductive electrode in organic solar cells. Molybdenum Trioxide (MoO3) doping of carbon nanotube Transparent Conductive electrodes makes p-doping, good energy-level alignment, and improved hole transport possible. In the present study, the performance of Non-Fullerene ITIC-OE Acceptor Organic Solar Cells with a transparent electrode fabricated from Carbon Nanotubes doped with Molybdenum trioxide (MoO3) is simulated using SCAPS 1-D. The optimized PCE of 24.94 %, Fill Factor (FF) of 74.02 %, Jsc of 35.32 mA/cm2 and Voc of 0.9539 V are shown in the current work by varying the band gap of MoO3 doped CNTs. Also, upgrading the simulated cell's Electron transport Layer (ETL) with SnO2, TiO2, and ZnO yields an optimized result with TiO2 ETL, having PCE of 25.71%, FF of 76.30%, Jsc of 35.32 mA/cm2, and Voc of 0.9539 V. These results demonstrated the possibilities for ITIC-OE acceptor Organic Solar Cells with Transparent Conductive Electrodes made of carbon nanotubes to advance device performance in the near future.
A Viscoelastic-Viscoplastic Model for Adhesives Subjected to Reversed Cyclic Load
Authors: Chen Yi , Smith Lloyd V. 
Published: September 2022

Abstract

This study aims to describe a toughened adhesive’s ratcheting-recovery behavior under reversed cyclic load using a viscoelastic-viscoplastic model. As most adhesives are based on synthetic polymers, their tensile and compression response can be different. A series of load-unload tests were conducted on bulk adhesives and bonded joints involving tension/compression-shear loads to characterize the initial yield surface. The effect of hydrostatic stress was studied by considering the instantaneous response and yield strength under tensile and compression loads. Given the observed modulus degradation and extensive permanent strain during reversed cyclic tests, time-dependent damage factors were considered for both viscoelastic and viscoplastic responses. The model was implemented in a finite element code and used to model the shear response to reversed cyclic load with varying frequency. Good agreement between the model and experiment was obtained. The consideration of both hydrostatic stress and damage was required to describe the observed adhesive reversed cyclic response.
Theaflavin indicates a high protective effect on vascular endothelial cells via stimulation of hydrogen sulfide production
Authors: Lee JicHyun , Terada Tomoko , Jiang WenQian , Miyazaki Hitoshi , Yoshida Shigeki 
Published: September 2022

Abstract
The present study compared the effects of green tea (–)-epigallocatechin gallate (EGCG) and black tea theaflavin on vascular endothelial cell (VEC) function via the gasotransmitters, hydrogen sulfide (H2S) and nitric oxide (NO). The reaction conditions for cell-free extracts of VECs and L-cysteine were optimized to detect H2S, which was measured using monobromobimane (MBB). EGCG and theaflavin were applied to VECs at 10 µM, and H2S and NO were measured using the MBB method and a NO-specific probe, diaminofluorescein-2 diacetate, respectively. The effects on the functions of VECs were evaluated based on wound healing and cell viability. Theaflavin significantly stimulated H2S production in VECs by 1.51-fold compared to the control, but EGCG showed no effect. In contrast, EGCG and theaflavin increased NO production (1.63 and 2.16-fold), wound healing (1.30- and 1.75-fold), and cell viability (85.0 and 90.0%). The potency of theaflavin was found to be higher than that of EGCG. By inhibiting cystathionine-γ-lyase activity with 100 µM of DL-propargylglycine (PPG) treatment, all cell responses were suppressed in both EGCG and theaflavin treatments, and the reduction rate in the case of theaflavin treatment was higher than that of the control and EGCG treatments in all responses. These results indicate that the protective effect of VECs is dependent on NO production, and that both EGCG and theaflavin have therapeutic potential in VECs. Theaflavin has a relatively higher therapeutic potential than EGCG by increasing H2S production, thereby affecting NO production and biological activity.