bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improve geo-routing in mobile multi-step networks using a two-tier cloud
Authors: Karimi Komeil , Gandomi Abolfazl 
Published: June 2022

Abstract
One of the challenges in the field of sensor networks is how to route and transmit information collected in the nodes of these networks. Since these networks are limited in terms of the amount of available energy, it is not possible to use the proposed methods for other networks in the sensor network. One of the goals of this project is to reduce multi-step communication to send information to the sink by focusing on delay-sensitive data. It also reduced the two types of energy consumption, namely the average energy loss of network nodes and the maximum network energy consumption by providing a solution in network routing, using fixed and mobile sinks. One of the problems of using a fixed sink is the lack of access to blind spots in the network. In such networks, several nodes are usually unable to send data to a fixed sink due to energy depletion. Although the mobile sink method improves energy efficiency and reduces end-to-end delays, the main problem with this method is waiting for a mobile sink to send information. The model presented in this project is the use of fixed and mobile sinks and a mechanism for clustering the network using the BSK-Means algorithm and connecting the cluster using the head to the sink in two levels. In this way, in addition to the segmentation, the network is divided into several zones and in each zone there is a super-node, each header sends its information through the sub-node in its area according to the priority queues. Finally, we will have a large reduction in energy loss, increase network life, reduce end-to-end latency and increase data delivery rate to the sink while maintaining service quality.
[18F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer’s disease pathology in APP/PS1 mice
Authors: Hsieh Chia-Ju , Hou Catherine , Zhu Yi , Lee Ji Youn , Kohli Neha , Gallagher Evan , Xu Kuiying , Lee Hsiaoju , Li Shihong , McManus Meagan J , Mach Robert H 
Published: June 2022

Abstract
Background
Oxidative stress is implicated in the pathogenesis of the most common neurodegenerative diseases, such as Alzheimer’s disease (AD). However, tracking oxidative stress in the brain has proven difficult and impeded its use as a biomarker. Herein, we investigate the utility of a novel positron emission tomography (PET) tracer, [18F]ROStrace, as a biomarker of oxidative stress throughout the course of AD in the well-established APP/PS1 double mutant mouse model. PET imaging studies were conducted in wild-type (WT) and APP/PS1 mice at 3 different time points, representing early (5 mo.), middle (10 mo.), and advanced (16 mo.) life (n = 6–12, per sex). Semi-quantitation SUVRs of the plateau phase (40-60min post-injection; SUVR40 − 60) of ten brain subregions were designated by the Mirrione atlas and analyzed by Pmod. Statistical parametric mapping (SPM) was used to distinguish brain regions with elevated ROS in APP/PS1 relative to WT in both sexes. The PET studies were validated by ex vivo autoradiography and immunofluorescence with the parent compound, dihydroethidium.
Results
[18F]ROStrace retention was increased in the APP/PS1 brain compared to age-matched controls by 10 mo. of age (p < 0.0001), and preceded the accumulation of oxidative damage in APP/PS1 neurons at 16mo. (p < 0.005). [18F]ROStrace retention and oxidative damages were higher and occurred earlier in female APP/PS1 mice as measured by PET (p < 0.001), autoradiography and immunohistochemistry (p < 0.05). [18F]ROStrace differences emerged mid-life, temporally and spatially correlating with increased Aβ burden (r2 = 0.36; p = 0.0003), which was also greatest in the female brain (p < 0.001).
Conclusions
[18F]ROStrace identifies increased oxidative stress and neuroinflammation in APP/PS1 female mice, concurrent with increased amyloid burden mid-life. Differences in oxidative stress during this crucial time may partially explain the sexual dimorphism in AD. [18F]ROStrace may provide a long-awaited tool to stratify at-risk patients who may benefit from antioxidant therapy prior to irreparable neurodegeneration.
Clinical comparison between advanced platelet-rich fibrin and connective tissue graft in the management of gingival recession: A randomized controlled split-mouth study
Authors: Abu-Ta'a Mahmoud 
Published: June 2022

Abstract
Objectives: To compare the clinical outcomes of advanced platelet-rich fibrin with connective tissue graft in management of gingival recessionMaterials & Methods: 15 patients with isolated bilateral gingival recession were selected (n= 30 defects). These defects were miller’s class I/II gingival recession on canine or premolar region. They were divided into two equal groups (n=15), these groups were left and right sides in the patient’s mouth (split-mouth), in which each patient was treated with two techniques as follows; One side (Group I) was treated by coronally advanced flap with advanced platelet-rich fibrin (A-PRF). Whereas, the other side (Group II) was treated by coronally advanced flap with connective tissue graft (CTG). Clinical parameters such as recession height (RH), recession width (RW), probing pocket depth (PPD), clinical attachment level (CAL), width of attached gingiva (WAG), and keratinized tissue height (KTH) were evaluated at baseline, 3 & 6 months. Changes in biotype, Recession Esthetic Score (RES) & Visual Analogue Score-Esthetics (VAS-E) were evaluated at the end of 6 months.Trial registration: Ethics approval number (Helsinki): PHRC/HC/877/21 and registered at the Clinical Trials Registry under the number NCT05267015Results: At the end of 6 months, RH & RW showed significant reduction from baseline in both groups (p≤0.05). The mean RC% was 67.2%±32.8% and 86.6±35.18% in Group I, II respectively. Intergroup analysis showed statistically significant differences in recession parameters between both groups at 3 & 6 months (p≤0.05), with better outcomes for the second group.Conclusion: Both therapeutic interventions were effective in management of gingival recession defects. with significant improvement in recession parameters among group II compared to group I.Clinical Relevance: Miller’s class I&II can be improved by using A-PRF+CAF. However, CTG+CAF gives better results.
Assessing the Impact of Client Knowledge and Demand on Service Provision from Antenatal to Postnatal Care - An Implementation Science Design
Authors: Mauluka Chancy , Chiumia Isabel Kazanga , Maliwichi Limbika , Stones William 
Published: June 2022

Abstract
BackgroundIn low resource countries suboptimal clinical care has been identified a contributor to maternal and infant mortality. This study aimed to test the impact of a community intervention promoting client demand on provision of care during ANC, labour and the first postnatal contact (PNC).Methods This was implementation science research in Kasungu district of Malawi using a quasi-experimental design with an intervention site where mothers were exposed to a package of interventions aiming to improve knowledge and demand. The results were compared with a site where there was no intervention in the same district. The intervention included checklists for mothers, posters and a Radio Distance Learning (RDL) program.The study used mixed methods (qualitative and quantitative). A total of 1040 mothers participated in individual interviews. Sixteen Focus Group Discussions (FGDs) were conducted with 128 mothers and 8 Key Informant Interviews were conducted with health workers. Health passports were used to check service provision at both comparison and intervention sites. In addition, mothers’ checklists were used at the intervention site to verify service provision.Quantitative data were processed in Stata 16.0 using binomial regression and two-sample proportion tests. NVivo 12 was used to process qualitative data for thematic analysis through coding and merging or creation of new codes.ResultsAt the intervention site there a 21.9% mean increase in knowledge of demandable services in ANC (43.3% to 56.1%, p<0.001,), intrapartum services for the mother (20.6%, 41.8% to 62.6%, p=0.003,) and the neonatal services before discharge (17.5%, 47% to 64.5%, p=0.0039). For PNC, changes were non-significant. Overall, women at the intervention site were 50% more likely than women at the comparison site to demand a service in the continuum of care (RR = 1.5). Actual service provision was increased at the intervention sites across all elements of the continuum, including laboratory testing, clinical examination of mothers and newborns and provision of essential interventions such as oxytocin for prevention of postpartum haemorrhage, chlorhexidine for umbilical cord care and vitamin K.ConclusionThe intervention positively contributed to increased knowledge on care practices, attitudes towards demand, actual demand for care practices, services provision and service satisfaction.
ABOS: An Attention-Based One-Stage Framework for Person Search
Authors: Chen Yuqi , Han Dezhi , Cui Mingming , Wu Zhongdai , Chang Chin-Chen 
Published: June 2022

Abstract
Person search is of great significance to public safety research, such as crime surveillance, video surveillance and security. Person search is a method of locating and identifying the queried person from a complete set of images. The main cause of false recall and missed detection in person search is the presence of person occlusion in the images. In order to improve the accuracy of person search when the person to be queried is occluded, this paper proposes an attention-based one-stage framework for person search (ABOS) using an anchor-free model as a baseline. The method uses the channel attention module to express different forms of occlusion and take full advantage of the spatial attention module to highlight the target region of the occluded pedestrians. These attention modules integrate deep and shallow features to guide the network to pay attention to the visible area of the occluded target and extract the semantic information of the pedestrians. Experimental results on CUHK-SYSU and PRW datasets show that the proposed person search method based on attention mechanism in this paper has better performance than existing methods, achieving 93.7% of mAP on CUHK-SYSU dataset and 46.4% of mAP on PRW dataset, respectively
Genetic Transformation of two Turkish rice (Oryza sativa L.) cutivars through Agrobacterium tumefaciens
Authors: Kahriz Mahsa Pourali , Khawar Khalid Mahmood 
Published: June 2022

Abstract
Background Seed weevils are one of the causes of post harvest rice yield losses in Turkey. There are many cultural and chemical methods to control these insects.PurposeThis study aimed to control these using Agrobacterium tumefaciens mediated genetic transformation in two rice cultivars namely Hamzadere and Osmancı-97.Methods and results Two days old germinated seeds of the two cultivars with 2-3 mm long shoots were used as explants. They were treated with Agrobacterium tumefciens containing a pTF101AoPR1AcBar plant expression vector containing the cry1Ac gene under the control of the wound-induced (AoPR1) promoter. The transformation event was genotype-dependent. Out of 3000 and 2600 explants of cv Hamzadere and cv Osmancık-97, only 92 (3.07%) and 32 (1.230%) plants were selected on MS medium containing 3.0 and 2.5 mg/l bialaphos. These were validated using PCR, bioassay, and ELISA tests. All plants were held in the greenhouse until T0 and T1 seed settings. three (0.10%) plants of cv Hamzadere and 5 (0.19%) plants of cv. Osmancık 97 could be validated through all tests in T₀ and T₁ generations in both cultivars of rice for the first time using a novel and a very simple transformation procedure.ConclusionThese results are very encouraging and will influence future rice transformation techniques and improve rice breeding technologies.
The Golgi-localized Sphingosine-1-Phosphate Phosphatase is Indispensable for Leishmania major
Authors: Okundaye Brian , Biyani Neha , Moitra Samrat , Zhang Kai 
Published: June 2022

Abstract
Sphingosine-1-phosphate phosphatase (SPP) catalyzes the dephosphorylation of sphingosine-1-phosphate (S1P) into sphingosine, the reverse reaction of sphingosine kinase. In mammals, S1P acts as a potent signaling molecule that regulates cell proliferation, migration, and immunity. In Leishmania, S1P production is crucial for the synthesis of ethanolamine and choline phospholipids, and cell survival under stress conditions. To better understand the roles of S1P, we characterized a SPP ortholog in Leishmania major which displays activity towards S1P but not structurally similar lipids such as ceramide-1-phosphate or lysophosphatidic acid. While this enzyme is found in the endoplasmic reticulum in mammalian cells, L. major SPP is localized at the Golgi apparatus. Importantly, chromosomal SPP alleles cannot be deleted from L. major even with the addition of a complementing episome, suggesting that endogenously expressed SPP is essential. Finally, SPP overexpression in L. major leads to a slower growth rate and heightened sensitivity to brefeldin A and sodium orthovanadate. Together, these results suggest that the equilibrium between S1P and sphingosine is vital for the function of Golgi apparatus in Leishmania.
Genetic architecture of berry aroma compounds in a quantitative trait locus mapping population of interspecific hybrid grapes (Vitis labruscana × Vitis vinifera)
Authors: Koyama Kazuya , Kono Atsushi , Ban Yusuke , Bahena-Garrido Sharon Marie , Ohama Tomoko , Iwashita Kazuhiro , Fukuda Hisashi , Goto-Yamamoto Nami 
Published: June 2022

Abstract
Background Although grapes (Vitis labruscana × Vitis vinifera) accumulate diverse groups of volatile compounds, their genetic regulation in different cultivars remains unelucidated. Therefore, this study investigated the volatile composition in the berries of an interspecific hybrid population from a V. labruscana “Campbell Early (CE)” × V. vinifera “Muscat of Alexandria (MA)” cross to understand the relationship among volatile compounds and their genetic regulation. Then, a quantitative trait locus (QTL) analysis of its volatile compounds was conducted. Results While MA contained higher concentrations of monoterpenes and norisoprenoids, CE contained higher concentrations of C6 compounds, lactones and shikimic acid derivatives, including volatiles characteristic to American hybrids, i.e., methyl anthranilate, o-aminoacetophenone and mesifurane. Furthermore, a cluster analysis of volatile profiles in the hybrid population discovered ten coordinately modulated free and bound volatile clusters. QTL analysis identified a major QTL on linkage group (LG) 5 in the MA map for 14 monoterpene concentrations, consistent with a previously reported locus. Additionally, several QTLs detected in the CE map affected the concentrations of specific monoterpenes, such as linalool, citronellol and 1,8-cineol, modifying the monoterpene composition in the berries. As for the concentrations of five norisoprenoids, a major common QTL on LG2 was discovered first in this study. Several QTLs with minor effects were also discovered in various volatile groups, such as lactones, alcohols and shikimic acid derivatives. Conclusions An overview of the profiles of aroma compounds and their underlying QTLs in a population of interspecific hybrid grapes in which muscat flavor compounds and many other aroma compounds were mixed variously were elucidated. Coordinate modulation of the volatile clusters in the hybrid population suggested an independent mechanism for controlling the volatiles of each group. Accordingly, specific QTLs with significant effects were observed for terpenoids, norisoprenoids and some volatiles highly contained in CE berries.
Demand experience of lymphoma patients with full disease trajectory：A qualitative research
Authors: Chen Jingxian , Yan Xingyu , Sheng Zhiqiong , Sun Caixia 
Published: June 2022

Abstract
Purpose: To develop a thorough understanding of lymphoma patients' psychological experiences at various stages of their supportive care needs, as well as to lay the groundwork for future research. This will serve as the foundation for the creation of a supportive care program for lymphoma patients. Methods: A phenomenological study was conducted using a semi-structured in-depth interview with 13 lymphoma patients from October-December 2021 in a tertiary general hospital in Wenzhou.Results: Lymphoma patients' supportive care needs during chemotherapy may be divided into five categories: information, emotional and social support, symptom management, financial support, and self-fulfillment; lymphoma patients' supportive care needs during recovery can be divided into four categories: Information, emotional and psychological support, social support, and reintegration needs are all important. Conclusion: Patients with lymphoma have various supportive care needs at different stages of their disease, so localized survivorship care strategies are needed to help with the overall management of lymphoma.
The Effect of Rebalancing Techniques on the Classification Performance in Cyberbullying Datasets
Authors: Khairy Marwa , Mahmoud Tarek M. , El-Hafeez Tarek Abd 
Published: June 2022

Abstract
Machine learning plays an increasingly significant role in the building of Cyberbullying detection systems. In cyberbullying datasets, the percentage of normal labeled classes is higher than the percentage of abnormal labeled ones, which is called as class imbalance problem in data mining. Class imbalance is a challenging problem in classification, especially in the two-class dataset. Conventional machine learning methods also decrease classification performance for unseen samples of the minority class when class distributions are imbalanced. This is because the model appears to be extensively influenced by the majority class. Many researchers have proposed over-sampling and under-sampling techniques in the literature to solve this problem. In this paper, the effect of over-sampling and under-sampling techniques in cyberbullying datasets is examined. For the experimental study, first we perform a preprocessing step to improve the performance of machine learning algorithms. Then we examine the effect of the imbalanced data on the classification performance for four cyberbullying datasets. To study the classification performance on the balanced cyberbullying datasets, four resampling techniques (namely, Random under-sampling, Random Oversampling, SMOTE, SMOTE + TOMEK) are used to rebalance these datasets. The impact of each rebalancing technique on the classification performance using 8 well-known classification algorithms is examined. Our experiments showed that the performance of resampling technique depends on the dataset size, the imbalance ratio, and the classifier used. The conducted experiments proved that there are no techniques that will always perform better the others.
Smokeless Tobacco Enhance Allergic Inflammation, Exacerbation of Asthma and Oxidative Stress in Asthmatic Patients from Algeria
Authors: Khaldi Taha , Boughemara Karima , Hesnie Yasmine Khodja , Amira Aicha Beya , Messarah Mahfoud , Boumendjel Amel 
Published: June 2022

Abstract
Background and objective
Despite their effects on human health, the link between smokeless tobacco (ST) consumption and asthma severity in asthmatic patients is still unknown. Thus, the present study aims to complete the lack of information by investigating the aggravation of inflammation, exacerbation of asthma, oxidative stress and cytotoxicity induced by ST in asthmatic patients.
Methods
The study recruited 80 male volunteers residing in Annaba town, Algeria, divided into four groups by using a questionnaire, each group consists of 20 male volunteers. Herein, biochemical parameters, hematological parameters, C-reactive protein (CRP), total IgE, interleukin-5 (IL-5), nitric oxide (NO) and oxidative stress were measured.
Results
The obtained results showed that ST clearly enhanced lung inflammation and exacerbation of asthma through total IgE, IL-5 and CRP increased production. In addition, ST was found to intensify oxidative stress via increased lipid peroxidation and decreased reduced glutathione (GSH) levels. Likewise, the biochemical and hematological parameters results showed that ST causes damage and inflammation to tissues.
Conclusion
Therefore, our study reveals that ST obviously enhances allergic inflammation in patients suffering from asthma.
Flame-retardant lignin-containing micro/nano fibrillated cellulose by steam explosion: preparation and comparative study
Authors: cheng liangsong , Nader Saad , Mauret Evelyne , Antoun Karina , ju zehui , Vahabi Henri , Lu Xiaoning , Brosse Nicolas 
Published: June 2022

Abstract
Lignin-containing micro/nano fibrillated cellulose (L-MNFCs) and phosphorylated L-MNFCs were produced from beechwood sawdust by combining steam explosion (SE) pretreatment, a bleaching step, a phosphorylation reaction using urea and etidronic acid, and an ultra-fine grinding. The contents of phosphorus and nitrogen on the cellulose surface were obtained by elemental analysis (P ≈ 2.7% and N ≈ 1.2% respectively). The chemical composition of the pulps was assessed by ionic chromatography (HPAEC PAD) and the morphology of phosphorylated (L-)NMFCs were analyzed by Morfi Neo. The successful grafting of phosphate groups was verified by FTIR, 13C CPMAS, 31P NMR. Thermal and fire behaviors were examined by TG/DTG analysis and pyrolysis combustion flow calorimetry (PCFC). It was found that SE pretreatment itself can significantly improve the thermal degradability and fire resistance of L-MNFCs. Phosphorylated (lignocellulosic) micro/nano fibrillated cellulose exhibiting a remarkable elevation in their thermal degradation and flame-retardancy have been produced.
Constituents of Prokaryotic Organism
Authors: Ubani Solomon I. 
Published: June 2022

Abstract
Research was to study exoenzyme a extracellular enzyme secretions by a cell and functions outside of organism. The research question was this for prokaryotic and eukaryotic organisms important for many biological processes. The method involved studies of cytoplasm within a cell surround by membrane. This consisted of examination of the material a gelatinous substance, organelles, sub-structures and inclusions. The results showed most prokaryotic had sizes from 0.5 to 2.0µm in diameter. This had three regions the membrane and some bacteria. The cellular concentrations had levels of 6 to 8 degrees of magnitude lower than those of high abundance of proteomes. The gene micro-arrays had interactions with oligo cells. It concluded phase extraction was needed in sets and preconcentration. The surrounds of glycan structures synthesis had presence of glycan in biological samples of immunologically based measurements of cells.
In-plane hyperbolic polariton tuners in terahertz and long-wave infrared regimes
Authors: Huang Wuchao , Folland Thomas G. , Sun Fengsheng , Zheng Zebo , Xu Ningsheng , Xing Qiaoxia , Jiang Jingyao , Caldwell Joshua , Yan Hugen , Chen Huanjun , Deng Shao-Zhi 
Published: June 2022

Abstract
Development of terahertz (THz) and long-wave infrared (LWIR) technologies is mainly bottlenecked by the limited intrinsic response of traditional materials. Hyperbolic phonon polaritons (HPhPs) of van der Waals semiconductors couple strongly with THz and LWIR radiation. However, the mismatch of photon−polariton momentum makes far-field excitation of HPhPs challenging. Here, we propose an In-Plane Hyperbolic Polariton Tuner and demonstrate a first device responding to direct far-field excitation and giving rise to a unique set of characteristic functions at far-field. Such a device is based on patterned surface directly written on van der Waals semiconductors; here α-MoO3. The resonances are found to strongly rely on in-plane hyperbolic polariton of patterned α-MoO3, exhibiting high quality factors up to 300, and to determine the characteristics of resultant tunable polarization and selection of the wavelength of reflection and transmission and regulation of output intensity. This is important to development of THz and LWIR miniaturized devices.