bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to boost the boosters? A survey-experiment on the effectiveness of different policies aimed at enhancing acceptance of a “Seasonal” vaccination against COVID-19
Authors: Goren Talia , Beeri Itai , Vashdi Dana Rachel 
Published: July 2022

Abstract
Background
Evidence suggests a gradual decrease in the effectiveness of the anti-COVID-19 vaccines, stressing the potential need for periodical booster shots. However, it is hard to tell whether previously applied policies for enhancing vaccine acceptance will be as effective for repeated periodical booster shots during a pandemic. Hence, this study aims to explore the effectiveness of different health policies on periodical vaccination acceptance amidst an ongoing pandemic.

Methods
A cross sectional online experiment was performed in a representative sample of 929 Israeli citizens. Participants were randomly allocated to 4 groups simulating different hypothetical periodical-vaccination-promoting policy scenarios: (1) Mandate (N = 229); (2) a negative monetary incentive (N = 244); (3) a positive monetary incentive (N = 228) and (4) information provision (N = 228). Compliance intentions and vaccine-acceptance-related variables were measured. Analysis included multivariate hierarchic logistic and linear regressions.

Results
Compliance intentions levels were medium (M = 3.13 on a 1–5 scale). Only 20.2% of the sample demonstrated strong acceptance of periodical vaccination, which is lower than the acceptance rate of the seasonal flu shot in the country in the year preceding the pandemic. Type of policy was related to the extent to which a respondent strongly agreed to be periodically vaccinated or not. Specifically, strong acceptance was more likely when positive or negative incentives were presented in comparison to the mandate or information provision conditions. However, when examining the extent of compliance among respondents who were less decisive, the type of policy did not predict the extent to which these respondents intended to comply. In addition, compliance intentions were related with the perceived benefits and barriers of the vaccine, the perceived efficacy of getting vaccinated and social norms. Hesitator’s intentions were additionally associated with anti-COVID-19 vaccination history, perceived severity of the disease and trust in government.

Conclusions
Pandemic-containing vaccines may be perceived as less effective and beneficial than pandemic-preventing vaccines. Individuals with different levels of motivation for periodical vaccination during a pandemic may be affected by different factors. While strongly opinionated individuals are affected by the type of vaccination-promoting policy, hesitators are affected by a larger number of factors, which provide policy makers with greater opportunities to enhance their vaccination intentions.
Survival benefits from neoadjuvant treatment in gastric cancer: a systematic review and meta-analysis
Authors: Hu Jianwen , Yang Yanpeng , Ma Yongchen , Ning Yingze , Chen Guowei , Liu Yucun 
Published: July 2022

Abstract
Background
Surgery is the main treatment option for patients with local gastric cancer. However, surgery alone is usually not sufficient for stomach cancer patients, and combined therapies are recommended for these patients. In recent studies, some preoperative treatments have shown benefits. However, the treatment selection is still uncertain because previous studies failed to obtain a statistically significant difference between preoperative chemotherapy and preoperative chemoradiotherapy. Therefore, we plan to perform a systematic review and meta-analysis to compare the benefits among these preoperative treatments.

Methods/design
This review includes randomized controlled trials with or without blinding as well as published studies, high-quality unpublished studies, full articles and meeting abstracts with an English context if sufficient results were provided for analysis. Data sources include the Cochrane Central Register of Controlled Trials, Embase, MEDLINE, major relevant international conferences and manual screening of references. Patients with a diagnosis of resectable primary gastric or EGJ adenocarcinoma (stage II or higher) who underwent surgery alone or preoperative treatment followed by surgery and who were pathologically confirmed as proposed by the AJCC 2017 guidelines without age, sex, race, subtypes of adenocarcinoma and molecular pathology limitations will be included. The following three interventions will be included: surgery alone, neoadjuvant chemistry followed by surgery and neoadjuvant chemoradiotherapy followed by surgery. All-cause mortality, overall survival (OS, the time interval from diagnosis to death) and/or progression-free survival (PFS, the time interval from diagnosis to disease progression or death from any cause) will be defined as major results of concern. The clinical and pathological response rate (according to RECIST and tumour regression score), R0 resection rate, quality of life and grade 3 or above adverse events (according to the National Cancer Institute Common Terminology Criteria for Adverse Events, NCI-CTCAE) will be defined as the secondary outcomes.

Discussion
The aim of this systematic review is to compare the benefits of different preoperative treatments for patients with locoregional stomach cancer. This systematic review will improve the understanding of the relative efficacy of these treatment options by providing the latest evidence on the efficacy of various treatment options in the management of gastric cancer patients and may guide clinical practice.

Systematic review registration
PROSPERO CRD4202123718
Investigation of technical quality of antenatal and perinatal services in a nationally representative sample of health facilities in Nepal
Authors: Khatri Resham B. , Durham Jo , Assefa Yibeltal 
Published: July 2022

Abstract
Background
Access to routine antenatal and perinatal services is improved in the last two decades in Nepal. However, gaps remain in coverage and quality of care delivered from the health facilities. This study investigated the delivery of technical quality antenatal and perinatal services from health facilities and their associated determinants in Nepal.

Methods
Data for this study were derived from the Nepal Health Facility Survey 2015. The World Health Organization's Service Availability and Readiness Assessment framework was adopted to assess the technical quality of antenatal and perinatal services of health facilities. Outcome variables included technical quality scores of i) 269 facilities providing antenatal services and ii) 109 facilities providing childbirth and postnatal care services (perinatal care). Technical quality scores of health facilities were estimated adapting recommended antenatal and perinatal interventions. Independent variables included locations and types of health facilities and their management functions (e.g., supervision). We conducted a linear regression analysis to identify the determinants of better technical quality of health services in health facilities. Beta coefficients were exponentiated into odds ratios (ORs) and reported with 95% confidence intervals (CIs). The significance level was set at p-value < 0.05.

Results
The mean score of the technical quality of health facilities for each outcome variable (antenatal and perinatal services) was 0.55 (out of 1.00). Compared to province one, facilities of Madhesh province had 4% lower odds (adjusted OR = 0.96; 95%CI: 0.92, 0.99) of providing better quality antenatal services, while health facilities of Gandaki province had higher odds of providing better quality antenatal services (aOR = 1.05; 95% CI: 1.01, 1.10). Private facilities had higher odds (aOR = 1.13; 95% CI: 1.03, 1.23) of providing better quality perinatal services compared to public facilities.

Conclusions
Private facilities provide better quality antenatal and perinatal health services than public facilities, while health facilities of Madhesh province provide poor quality perinatal services. Health system needs to implement tailored strategies, including recruiting health workers, supervision and onsite coaching and access to necessary equipment and medicine in the facilities of Madhesh province. Health system inputs (trained human resources, equipment and supplies) are needed in the public facilities. Extending the safe delivery incentive programme to the privately managed facilities could also improve access to better quality health services in Nepal.
CircCEP85 upregulates IGF1 expression to promote breast cancer progression via sponging miR-1193
Authors: Gao Fei , Han Jianjun , Jia Li , He Jun , Wang Yun , Chen Mi 
Published: July 2022

Abstract
Background
Increasing evidence has suggested that circular RNAs (circRNAs) play critical roles in breast cancer (BC) progression. However, the expression level and potential functional role of circRNA centrosomal protein 85 (circCEP85) in BC remains largely unknown. Here, we aimed to explore the role of circCEP85 in BC.

Methods
The levels of circCEP85, insuline-like growth factor I (IGF1) mRNA and microRNA-1193 (miR-1193) were examined by quantitative real-time polymerase chain reaction. The protein level was measured by Western blot. Cell proliferation, migration, apoptosis, angiogenesis and stemness were assessed by cell counting kit-8, 5-ethynyl-2’-deoxyuridine assay, transwell assay, flow cytometry, tube formation and sphere formation assays. Xenograft mouse models were conducted to evaluate the effect of circCEP85 in BC in vivo. Moreover, dual-luciferase reporter, RNA pull-down, and RNA immunoprecipitation (RIP) assays were preformed to confirm the interaction between miR-1193 and circCEP85 or IGF1.

Results
CircCEP85 was upregulated in BC tissues and cells. Silencing of circCEP85 inhibited proliferation, invasion, angiogenesis and stemness, but promoted apoptosis in BC cells in vitro. In addition, circCEP85 silencing inhibited tumor growth in vivo. Mechanistically, circCEP85 elevated IGF1 expression via sponging miR-1193 to promote breast cancer progression.

Conclusion
The circCEP85-miR-1193-IGF1 axis regulated BC progression via the competitive endogenous RNA (ceRNA) mechanism. CircCEP85 might be a prognostic biomarker and therapeutic target for BC.
Biopsies of osseous jaw lesions using 3D-printed surgical guides: a clinical study
Authors: Postl Lukas , Mücke Thomas , Hunger Stefan , Wuersching Sabina Noreen , Holberg Svenia , Bissinger Oliver , Burgkart Rainer , Malek Michael , Krennmair Stefan 
Published: July 2022

Abstract
Background
Bone biopsies are often necessary to make a diagnosis in the case of irregular bone structures of the jaw. A 3D-printed surgical guide may be a helpful tool for enhancing the accuracy of the biopsy and for ensuring that the tissue of interest is precisely removed for examination. This study was conducted to compare the accuracy of biopsies performed with 3D-printed surgical guides to that of free-handed biopsies.

Methods
Computed tomography scans were performed on patients with bony lesions of the lower jaw. Surgical guides were planned via computer-aided design and manufactured by a 3D-printer. Biopsies were performed with the surgical guides. Bone models of the lower jaw with geometries identical to the patients’ lower jaws were produced using a 3D-printer. The jaw models were fitted into a phantom head model and free-handed biopsies were taken as controls. The accuracy of the biopsies was evaluated by comparing the parameters for the axis, angle and depth of the biopsies to the planned parameters.

Results
Eight patients were included. The mean deviation between the biopsy axes was significantly lower in guided procedures than in free-handed biopsies (1.4 mm ± 0.9 mm; 3.6 mm ± 1.0 mm; p = 0.0005). The mean biopsy angle deviation was also significantly lower in guided biopsies than in free-handed biopsies (6.8° ± 4.0; 15.4° ± 3.6; p = 0.0005). The biopsy depth showed no significant difference between the guided and the free-handed biopsies.

Conclusions
Computer-guided biopsies allow significantly higher accuracy than free-handed procedures.
Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress
Authors: Marx Christian , Sonnemann Jürgen , Maddocks Oliver D. K. , Marx-Blümel Lisa , Beyer Mandy , Hoelzer Doerte , Thierbach René , Maletzki Claudia , Linnebacher Michael , Heinzel Thorsten , Krämer Oliver H. 
Published: July 2022

Abstract
Background
Metabolic adaptations can allow cancer cells to survive DNA-damaging chemotherapy. This unmet clinical challenge is a potential vulnerability of cancer. Accordingly, there is an intense search for mechanisms that modulate cell metabolism during anti-tumor therapy. We set out to define how colorectal cancer CRC cells alter their metabolism upon DNA replication stress and whether this provides opportunities to eliminate such cells more efficiently.

Methods
We incubated p53-positive and p53-negative permanent CRC cells and short-term cultured primary CRC cells with the topoisomerase-1 inhibitor irinotecan and other drugs that cause DNA replication stress and consequently DNA damage. We analyzed pro-apoptotic mitochondrial membrane depolarization and cell death with flow cytometry. We evaluated cellular metabolism with immunoblotting of electron transport chain (ETC) complex subunits, analysis of mitochondrial mRNA expression by qPCR, MTT assay, measurements of oxygen consumption and reactive oxygen species (ROS), and metabolic flux analysis with the Seahorse platform. Global metabolic alterations were assessed using targeted mass spectrometric analysis of extra- and intracellular metabolites.

Results
Chemotherapeutics that cause DNA replication stress induce metabolic changes in p53-positive and p53-negative CRC cells. Irinotecan enhances glycolysis, oxygen consumption, mitochondrial ETC activation, and ROS production in CRC cells. This is connected to increased levels of electron transport chain complexes involving mitochondrial translation. Mass spectrometric analysis reveals global metabolic adaptations of CRC cells to irinotecan, including the glycolysis, tricarboxylic acid cycle, and pentose phosphate pathways. P53-proficient CRC cells, however, have a more active metabolism upon DNA replication stress than their p53-deficient counterparts. This metabolic switch is a vulnerability of p53-positive cells to irinotecan-induced apoptosis under glucose-restricted conditions.

Conclusion
Drugs that cause DNA replication stress increase the metabolism of CRC cells. Glucose restriction might improve the effectiveness of classical chemotherapy against p53-positive CRC cells.

Graphical Abstract
The topoisomerase-1 inhibitor irinotecan and other chemotherapeutics that cause DNA damage induce metabolic adaptations in colorectal cancer (CRC) cells irrespective of their p53 status. Irinotecan enhances the glycolysis and oxygen consumption in CRC cells to deliver energy and biomolecules necessary for DNA repair and their survival. Compared to p53-deficient cells, p53-proficient CRC cells have a more active metabolism and use their intracellular metabolites more extensively. This metabolic switch creates a vulnerability to chemotherapy under glucose-restricted conditions for p53-positive cells.
The influence of learning mode and learning sharing behavior on the synchronicity of attention of sharers and learners
Authors: Xiaojun Zhao , Xinrui Kang , Xupeng Li 
Published: July 2022

AbstractAttention is the concentration of mental activities to a certain object, and students' inattentiveness in class directly affects their learning efficiency. As an emerging technology of educational application, augmented reality (AR) technology combines virtual reality and three-dimensional reconstruction to bring multisensory stimulation to students, enhancing immersion and attention in learning. A quantitative study was conducted on third-grade pupils. Study 1 examined whether learning mode and learning sharing behavior affect the synchronization of sharers’ and learners’ attention. Study 2 examined the impact of learning mode and sharing role on sharer and shared. The results showed that compared with learning alone, when sharing, the attention score of AR group is higher than that of text group. Whether it is the sharer or the shared, the attention score of AR group is higher than that of text group. AR has more advantages than text in terms of learning attention. In future research, it is optional to diversify AR learning materials and further use near-infrared spectroscopy technology to study interactive learning in AR mode.
Determination of the polymer composition of mid-twentieth century purses by Raman spectroscopy
Authors: Boyden Mary N. , Kleist Elyse M. , Asztalos Courtney K. , Korter Timothy M. 
Published: July 2022

Abstract
A database was constructed of 134 reference plastic samples and their Raman spectra to aid in the rapid and accurate identification of the polymer composition of mid-twentieth century plastic purses and their component parts from the Plastics Artifacts Collection at Syracuse University Libraries. Work began by making and testing the database, which led to the determination that matching artifact spectra to reference sample spectra worked well for artifact spectra having signal-to-noise ratios down to 30:1. This finding allowed for using reduced laser power as necessary to protect delicate and pigmented artifacts. These studies enabled the definitive chemical identification of seven selected artifacts, showing that the majority are composed of single plastics including polystyrene, poly(methyl methacrylate), or cellulose acetate. However, it was discovered that one of the purses was composed of both poly(methyl methacrylate) and cellulose acetate. The compositions of three artifacts of unknown composition were discovered, corrections to the existing records were made for three other artifacts, and the composition of one artifact was confirmed. This decisive study will contribute to the archival processing and preservation of these artifacts.
Utilization of a meteorological satellite as a space telescope: the lunar mid-infrared spectrum as seen by Himawari-8
Authors: Nishiyama Gaku , Namiki Noriyuki , Sugita Seiji , Uno Shinsuke 
Published: July 2022

AbstractThe Japanese meteorological satellite Himawari-8 has captured the Earth’s atmosphere and stars, planets, and the Moon in its field of view, enabling us to capture their spectroscopy with 16 bands from visible to mid-infrared wavelengths. The nine infrared bands in the Advanced Himawari Imager (AHI) onboard Himawari-8 are unique in spaceborne observations and are potentially useful for lunar science. In addition, infrared bands of AHI cover wavelengths similar to those of other interplanetary instruments and thus are useful for calibrations. However, infrared AHI data have not yet been investigated in planetary science. To confirm the utility of AHI for planetary science, we develop a procedure to retrieve the lunar infrared spectrum and compare it with thermal conduction simulations. Our analysis shows that lunar brightness temperature curves can be obtained in the morning, evening, and nighttime for all nine bands. Particularly at 8.5 μm, they show a good agreement with previous observations by the Diviner radiometer onboard NASA’s Lunar Reconnaissance Orbiter. As pointed out previously, the brightness temperatures differ between the bands, indicating temperature mixing within a pixel. Our simulation suggests that surface roughness as steep as those measured at the Apollo landing sites significantly contributes to the observed brightness temperature differences in the morning and evening; however, nighttime brightness temperatures are greatly affected by rocks with higher thermal inertia than the regolith. The rock abundances are estimated to be 0.18–0.48% and 6.1–10.3% at the equator and within Tycho crater, respectively. Our estimations from AHI data are consistent with those of Diviner. These results support the idea that AHI potentially serves as a space telescope for future lunar and planetary sciences, for example, for constraining water content on the lunar surface.
Graphical Abstract
Wide-field swept-source OCT angiography of the periarterial capillary-free zone before and after anti-VEGF therapy for branch retinal vein occlusion
Authors: Tang Wenyi , Liu Wei , Guo Jingli , Zhang Lili , Xu Gezhi , Wang Keyan , Chang Qing 
Published: July 2022

Abstract
Background
The aim of the study was to investigate the changes in the periarterial capillary-free zone (paCFZ) after anti-vascular endothelial growth factor (VEGF) therapy in patients with branch retinal vein occlusion (BRVO) by wide-field swept-source optical coherence tomography angiography (SS-OCTA) and assess their associations with clinical outcomes.

Methods
In this retrospective observational study of 54 treatment-naïve BRVO patients with macular edema, we reviewed the findings of 12 × 12 mm2 SS-OCTA at baseline, 3, 6, and 12 months after intravitreal ranibizumab injections. The paCFZ and major retinal artery areas were measured on SS-OCTA images. The paCFZ area to artery area (P/A) ratio was calculated.

Results
The paCFZ areas and P/A ratios of first- and second-order arteries were significantly greater in BRVO eyes than in contralateral eyes (all P < 0.01), but there were no differences in the first- and second-order artery areas (P = 0.20 and 0.25, respectively). The paCFZ areas and P/A ratios decreased significantly at 3, 6, and 12 months after anti-VEGF therapy (all P < 0.01). The baseline P/A ratio was significantly correlated with the baseline best-corrected visual acuity (BCVA), central retinal thickness, and their improvements at 3, 6, and 12 months (all P < 0.05). Baseline BCVA and P/A ratios of first- and second-order arteries were independently associated with the final BCVA in multivariate linear regression.

Conclusions
Wide-field SS-OCTA shows that anti-VEGF therapy can lead to a significant improvement in the paCFZ parameters in BRVO. Smaller baseline P/A ratios on SS-OCTA tend to predict better visual outcomes at 12 months after anti-VEGF therapy.
Support structure tomography using per-pixel signed shadow casting in human manikin 3D printing
Authors: Jung Jin Young , Chee Seonkoo , Sul In Hwan 
Published: July 2022

AbstractThis study proposes an advanced algorithm for predicting the optimal orientation in human manikin 3D printing. We can print the manikin mesh data on any scale depending on the user’s needs. Once the 3D printing scale was determined, the manikin data were dissected based on the 3D printer’s maximal printing volume using our previous work. Then, we applied the newly proposed algorithm, designated as “per-pixel signed-shadow casting,” to each dissected manikin part to calculate the volumes of the object and the support structure. Our method classified the original mesh triangles into three groups—alpha, beta, and top-covering—to eliminate the need for special hardware such as graphic cards. The result is shown as a two-dimensional bitmap file, designated as “tomograph”. This tomograph represents the local support structure distribution information on a visual and quantitative basis. Repeating this tomography method for the three rotational axes resulted in a four-dimensional (4D) box-shaped graph. The optimal orientation of any arbitrary object is easily determined from the lowest-valued pixel in the 4D box graph. We applied this proposed method to several basic primitive shapes with different degrees of symmetry and complex shapes, such as the famous “Stanford Bunny”. Finally, the algorithm was applied to human manikins using several printing scales. The theoretical values were compared with those obtained from analytical or g-code-based experimental volumes.