bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cone beam CT-guided navigation bronchoscopy: a cost-effective alternative to CT-guided transthoracic biopsy for diagnosis of peripheral pulmonary nodules
Authors: Kops Stephan E P , Verhoeven Roel L J , Vermeulen Robin J , Rovers Maroeska M , van der Heijden Erik H F M , Govers Tim M 
Published: September 2022

ObjectivesTo determine if cone beam CT-guided navigation bronchoscopy (CBCT-NB) is a cost-effective diagnostic procedure in patients with a pulmonary nodule (PN) with an intermediate risk for lung cancer.Materials and methodsTwo decision analytical models were developed to compare the long-term costs, survival and quality of life. In the first model, CBCT-NB was compared with CT-guided transthoracic needle biopsy (TTNB) in TTNB eligible patients. In the second model, CBCT-NB was compared with direct treatment (without pathology proven lung cancer) in patients for whom TTNB is not suitable. Input data were gathered in-house, from literature and expert opinion. Effects were expressed in quality-adjusted life years (QALYs). Sensitivity analyses were used to assess uncertainty.ResultsCBCT-NB can be cost-effective in TTNB eligible patients with an incremental cost-effectiveness ratio of €18 416 in an expert setting. The probabilistic sensitivity analysis showed that in 69% and 90% of iterations CBCT-NB remained cost-effective assuming a willingness to pay (WTP) of €20 000 and €80 000 per QALY. CBCT-NB dominated in the treatment strategy in which TTNB is not suitable. The probabilistic sensitivity analysis showed that in 95% of iterations CBCT-NB remained the dominant strategy, and CBCT-NB remained cost-effective in 100% of iterations assuming a WTP limit of €20 000. In the comparison between CBCT NB and TTNB, the deterministic sensitivity analysis showed that the diagnostic properties and costs of both procedures have a large impact on the outcome.ConclusionsCBCT-NB seems a cost-effective procedure when compared with TTNB and when compared with a direct treatment strategy in patients with an intermediate risk PN.
Cardiac postacute sequelae symptoms of SARS-CoV-2 in community-dwelling adults: cross-sectional study
Authors: Ogungbe Oluwabunmi , Gilotra Nisha A , Davidson Patricia M , Farley Jason E , Dennison Himmelfarb Cheryl R , Post Wendy S , Commodore-Mensah Yvonne 
Published: September 2022

ObjectiveTo examine risk factors for cardiac-related postacute sequelae of SARS-CoV-2 infection (PASC) in community-dwelling adults after acute COVID-19 infection.MethodsWe performed a cross-sectional analysis among adults who tested positive for COVID-19. Outcomes were self-reported cardiac-related PASC. We conducted stepwise multivariable logistic regression to assess association between the risk factors (existing cardiovascular disease (CVD), pre-existing conditions, days since positive test, COVID-19 hospitalisation, age, sex, education, income) and cardiac-related PASC.ResultsIn a sample of 442 persons, mean (SD) age was 45.4 (16.2) years, 71% were women, 13% were black, 46% had pre-existing conditions, 23% had cardiovascular (CV) risk factors and 4% had CVD. Prevalence of cardiac PASC was 43% and newly diagnosed cardiac conditions were 27%. The odds for cardiac-related PASC were higher among persons with underlying pre-existing conditions (adjusted OR (aOR): 2.00, 95% CI: 1.28 to 3.10) and among those who were hospitalised (aOR: 3.03, 95% CI: 1.58 to 5.83).ConclusionsMore than a third of persons with COVID-19 reported cardiac-related PASC symptoms. Underlying CVD, pre-existing diseases, age and COVID-19 hospitalisation are possible risk factors for cardiac-related PASC symptoms. COVID-19 may exacerbate CV risk factors and increase risk of complications.
Association of serum uric acid levels with cardiovascular and all-cause mortality in hypertensive patients in China: a cohort study
Authors: Zhang Shu-Xian , Yu Yu-Ling , Tang Song-Tao , Lo Kenneth , Feng Ying-Qing , Chen Ji-Yan 
Published: September 2022

Abstract

Purpose
The present study aimed to assess the association of elevated serum uric acid (SUA) and hypouricemia with all-cause mortality and cardiovascular mortality in Chinese hypertensive patients.

Methods
In the present prospective cohort, 9325 hypertensive patients from Dongguan, China were enrolled from 2014 to 2018 for analysis. Participants were categorised by quintiles of SUA. The HRs and 95% CIs for the association between SUA, all-cause and cardiovascular mortality were evaluated using the multivariate Cox regression model. After adjusting for multiple confounders, restricted cubic spline analysis was conducted to demonstrate the shape of relationship.

Results
After a median follow-up of 4.18 years for 9325 participants, there were 409 (4.4%) and 151 (1.6%) reported cases of all-cause and cardiovascular mortality, respectively. By using the third quintile of SUA (6.68 mg/dL to &lt;7.55 mg/dL for men, 5.63 mg/dL to &lt;6.42 mg/dL for women) as reference, the highest quintiles of SUA were associated with an elevated risk of all cause (HR: 1.34, 95% CI 1.00 to 1.80) in the crude model, but the association was not significant after adjusting for multiple comparisons. The association between low SUA and mortality and the dose–response analysis on the non-linearity of SUA–mortality relationship were not statistically significant.

Conclusions
Although the association between SUA levels, all-cause and cardiovascular disease mortality did not appear to be significant among Chinese hypertensive patients, the findings might be confounded by their medical conditions. Further studies are needed to verify the optimal SUA levels for hypertensive patients.
Prevalence of macrolide and fluoroquinolone resistance-associated mutations in Mycoplasma genitalium in metropolitan and overseas France
Authors: Pereyre Sabine , Laurier-Nadalié Cécile , Le Roy Chloé , Guiraud Jennifer , Dolzy Amandine , Hénin Nadege , Gardette Marie , Bébéar Cécile 
Published: September 2022

ObjectiveLimited macrolide and fluoroquinolone resistance data are available in France for Mycoplasma genitalium. We performed a multicentre cross-sectional study to investigate the prevalence of macrolide and fluoroquinolone resistance-associated mutations in M. genitalium-positive patients in metropolitan France between 2018 and 2020 and in overseas France in 2018 and 2019.MethodsEach year, a 1-month prospective collection of M. genitalium-positive specimens was proposed to metropolitan French microbiology diagnostic laboratories, and a similar 3-month collection was proposed to overseas French laboratories. Resistance-associated mutations were detected using commercial kits and sequencing.ResultsA total of 1630 M. genitalium-positive specimens were analysed. In metropolitan France, the prevalence of macrolide resistance-associated mutations ranged between 34.7% (95% CI 29.4% to 40.4%) and 42.9% (95% CI 37.1% to 49.0%) between 2018 and 2020 and was significantly higher in men (95% CI 52.4% to 60.2%) than in women (95% CI 15.9% to 22.2%) (p<0.001). These prevalences were significantly higher than those of 6.1% (95% CI 3.7% to 10.3%) and 14.7% (95% CI 10.9% to 19.6%) observed in overseas France in 2018 and 2019 (p<0.001), where no difference between genders was noted. The prevalence of fluoroquinolone resistance-associated mutations was also significantly higher in metropolitan France (14.9% (95% CI 11.2% to 19.5%) to 16.1% (95% CI 12.1% to 21.2%)) than in overseas France (1.3% (95% CI 0.4% to 3.7%) and 2.6% (95% CI 1.3% to 5.3%) in 2018 and 2019, respectively) (p<0.001), with no difference between men and women regardless of the location.ConclusionThis study reports the high prevalence of macrolide and fluoroquinolone resistance-associated mutations in M. genitalium in metropolitan France and highlights the contrast with low prevalence in overseas France. In metropolitan France, macrolide resistance-associated mutation prevalence was three times higher in men than in women, which was likely to be driven by the proportion of men who have sex with men. This suggests that gender and sexual practice should also be taken into account for the management of M. genitalium infections.
Determinants of adherence to daily PrEP measured as intracellular tenofovir diphosphate concentrations over 24 months of follow-up among men who have sex with men
Authors: van den Elshout Mark AM , Hoornenborg Elske , Coyer Liza , Anderson Peter L , Davidovich Udi , de Vries Henry JC , Prins Maria , Schim van der Loeff Maarten F 
Published: September 2022

ObjectivesAdherence is key to the effectiveness of oral pre-exposure prophylaxis (PrEP) to prevent HIV. Therefore, we aimed to explore factors associated with adherence to daily PrEP (dPrEP).MethodsMen who have sex with men (MSM) using dPrEP (emtricitabine/tenofovir disoproxil) within the Amsterdam PrEP demonstration project at the Public Health Service of Amsterdam, provided dried blood spots (DBS) 12 and 24 months after PrEP initiation. From DBS, we determined intracellular tenofovir diphosphate (TFV-DP) concentrations to assess adherence; TFV-DP ≥700 fmol/punch was considered adequate. We assessed associations of sociodemographic, clinical and behavioural characteristics with TFV-DP concentrations using multivariable linear regression.ResultsOf 263 participants who attended 12-month or 24-month study visits while on dPrEP, 257 (97.7%) provided DBS at one or both visits (492 DBS in total). Median TFV-DP concentration was 1299 (IQR 1021–1627) fmol/punch (12 months: 1332 (1087–1687); 24 months: 1248 (929–1590]). Higher TFV-DP concentrations were associated with: older age (p=0.0008), condomless anal sex with a casual partner in 6 months preceding PrEP initiation (+166 fmol/punch; 95% CI 36.5 to 296) and using a mobile application providing visualised feedback on PrEP use and sexual behaviour (+146 fmol/punch; 95% CI 28.1 to 263). Lower TFV-DP concentrations were associated with longer duration of PrEP use (24 vs 12 months; −91.5 fmol/punch; 95% CI −155 to −28.1). Time-updated number of sex partners, diagnosed STIs and chemsex were not associated with TFV-DP concentrations.ConclusionsOverall, TFV-DP concentrations were high among MSM using dPrEP, indicating excellent adherence. Especially older participants, those who reported condomless anal sex with a casual partner prior to PrEP initiation and those who used an app with visualised feedback showed higher levels of adherence. As TFV-DP concentrations had decreased slightly at 2 years of PrEP use when compared with 1 year, we emphasise the importance of adherence counselling to those who continue using PrEP.Trial registration numberNL5413.
Resuscitation code status among emergency department patients: decision support education video pilot study
Authors: Finch Alexander S , Stanich Jessica A , Spadaro Maria J , Tschautscher Craig F , Walker Laura E , Loprinzi Brauer Caitlin E 
Published: September 2022

ObjectivesEstablishment of code status can be challenging in the acute care setting. The primary objective of the present study was to evaluate whether patients or their surrogate decision-makers were comfortable watching an educational video about resuscitation.MethodsThis interventional pilot study involved a pre- and a postintervention survey of a convenience sample of emergency department (ED) patients who were admitted to the hospital. The study was conducted at an academic level-1 trauma centre within the normal flow of patient care over 4 months in 2017.ResultsIn total, 50 patients enrolled in the study. Among them, 82% were ‘very comfortable’ and 14% were ‘moderately comfortable’ watching the video. Overall, 61% of respondents were ‘very comfortable’ recommending the video to others. Watching the video resulted in a change in code status for 9 patients.ConclusionsOur results indicate that patients felt comfortable watching the video and recommending the video for further use. Watching the video did not result in a change in code status for most patients in this study. The study results indicate that a standardised patient education video on resuscitation code status was acceptable to patients and their family members and has potential for increased use in the ED.
Evolution properties of the knot’s defect
Authors: Morozov A. , Tselousov N. 
Published: September 2022

AbstractThe defect of differential (cyclotomic) expansion for colored HOMFLY-PT polynomials is conjectured to be invariant under any antiparallel evolution and change linearly with the evolution in any parallel direction. In other words, each $${{\mathcal {R}}}$$
R
-matrix can be substituted by an entire 2-strand braid in two different ways: the defect remains intact when the braid is antiparallel and changes by half of the added length when the braid is parallel.
Duality between operator ordering factor and massless scalar field
Authors: He Dongshan , Cai Qing-yu 
Published: September 2022

AbstractIn order to investigate the role of quantum effects in the evolution of the universe, one can either use the Wheeler–DeWitt equation (WDWE) that contains an operator ordering factor, or add an item called massless scalar field to WDWE. In this paper, we study the relationship between operator ordering factor and massless scalar field, by applying de Broglie–Bohm quantum trajectory approach to WDWE. In theory, the evolution of the universe is determined by action, i.e., the phase part of the wavefunction of the universe. For the case of operator ordering factor and the case of massless scalar field, the functions that determine the phase part of the wavefunction of the universe satisfy the same differential equation, both in the minisuperspace model and in the Kantowski–Sachs model. This shows the equivalence of using operator ordering factor or massless scalar field to study evolution of the universe. Since there is no accelerating solution of WDWE with operator ordering factor for a grownup universe in the minisuperspace model, the equivalence of the operator ordering factor and the massless scalar field rules out the possibility of a massless scalar field as the candidate for dark energy, if the current universe is indeed homogeneous and isotropic.
Causal structure of accelerating black holes
Authors: Cembranos Jose A. R. , Garay Luis J. , Ortega Sergio A. 
Published: September 2022

AbstractAccelerating black holes are described by the so-called C-metric. In this work, we analyse the causal structure of such black holes by using null geodesics. We construct explicitly the relevant Penrose diagrams. First, we recover well-known results associated with the sub-accelerating black holes. Then, we extend the study to the super-accelerating case, in which an additional essential singularity appears. In addition, we consider accelerating black holes with negative masses. We show that they are equivalent to the geometry described by the black hole metric beyond conformal infinity. We compare our results with the Schwarzschild geometry to facilitate understanding and to highlight the interest of the new features.
Primordial black holes and gravitational waves in teleparallel Gravity
Authors: El Bourakadi K. , Asfour B. , Sakhi Z. , Bennai M. , Ouali T. 
Published: September 2022

AbstractIn this paper, we consider the possible effect of the teleparallel gravity on the production of the primordial black holes (PBH) and on the gravitational waves (GWs). We investigate the relationship between the slow roll, the e-folds number and the teleparallel parameters. We show that in the case of the teleparallel parameter $$\delta =3$$

δ
=
3

, the e-folds number reaches the values 50 and 60 in consistency with the contour plot of the $$(r,n_{s})$$

(
r
,

n
s

)

plane obtained by Planck data at $$1\sigma $$

1
σ

and $$2\sigma $$

2
σ

C.L. Furthermore, we use the fraction of the energy density and the variance of the density perturbations approach to study the abundance of the production PBH. We find that the PBH overproduction can be satisfied for specific values of parameters of the non-adiabatic curvature power spectrum at some narrow parametric resonance. Moreover, to explain the GWs expected by observations, the duration of preheating should be bounded by values less or equal to 2. This bound is in agreement with values of the tensor-to-scalar ratio and the spectral index constrained by Planck data.
ЛІКУВАННЯ ГІПЕРПЛАЗІЇ ЕНДОМЕТРІЯ БЕЗ АТИПІЇ МІКРОНІЗОВАНИМ ПРОГЕСТЕРОНОМ. ОЧІКУВАНІ ТА РЕАЛЬНІ РЕЗУЛЬТАТИ
Authors: Хасхачих Д. А. , Потапов В. О. , Кукіна Г. О. 
Published: September 2022

Мета дослідження – виявити вплив експресії рецепторів до прогестерону на ефективність лікування гіперплазії ендометрія без атипії у жінок репродуктивного віку та встановити ефективність лікування у групах із низькою та високою рецептивністю ендометрія.
Матеріали та методи. Було проведено проспективне когортне дослідження у 45 пацієнток репродуктивного віку (25–38 років) з аномальними матковими кровотечами (АМК). Контрольну групу склали 15 пацієнток зі змінами ендометрія секреторного типу. Матеріал для морфологічного та імуногістохімічного дослідження отримували шляхом вишкрібання порожнини матки. Дослідження рецепторів до естрогенів та прогестерону проводили імуногістохімічним методом у лабораторії імуногістохімії Дніпровського державного медичного університету (ДДМУ). Досліджувану групу було поділено на дві підгрупи за ступенем експресії прогестеронових рецепторів. Ступінь експресії рецепторів до прогестерону визначали за результатами H-score: 0–100 – низький, 101 і більше – високий. Всі пацієнтки отримували лікування мікронізованим прогестероном у дозі 100 мг на добу сублінгвально в безперервному режимі протягом 6 місяців. Критерієм позитивного ефекту вважали: відсутність скарг у пацієнток та відсутність гіперплазії ендометрія (ГЕ) за результатами пайпель-біопсії ендометрія після 6 місяців лікування.
Результати дослідження та їх обговорення. У всіх жінок спостерігали значну експресію естрогенових рецепторів (ЕР) у клітинах ендометрія, що зумовлювало його проліферативну активність на тлі зниження експресії рецепторів до прогестерону (ПР). За результатами дослідження, у жінок із відсутністю ефекту від проведеної терапії, на відміну від жінок з ефективно проведеною терапією, спостерігали зниження експресії рецепторів до прогестерону на 65 %. У результаті проведеного лікування, за результатами морфологічного дослідження зіскрібків ендометрія, у 12 жінок (48 %) відбулася регресія гіперболізованого ендометрія і спостережено гістологічну нормалізацію співвідношення стромального й епітеліального компонентів. У 27 жінок (37,8 %) знову було діагностовано просту неатипову гіперплазію ендометрія. У 18 (13,3 %) жінок було діагностовано комплексну неатипову гіперплазію ендометрія, тобто спостережено прогресування захворювання. Таким чином, ефективність призначених прогестинів за результатами терапії упродовж 6 місяців склала 75 %.
Висновок. У всіх жінок спостережено значну експресію рецепторів до естрогенів у клітинах ендометрія, що зумовлювало його проліферативну активність на тлі зниження експресії рецепторів до прогестерону на 65 %, що призвело до відсутності ефекту від терапії у 25 % жінок.
Faking Orgasms
Authors: Rahbari Ladan 
Published: September 2022

Abstract
The phenomenon of faking orgasms has been the subject of extensive feminist inquiry, but in contemporary Iran, where sex and sexuality remain sensitive and controversial topics, the topic has not received much scholarly attention. This exploratory pilot study uses qualitative methods to explore the prevalence and the reasons for faking orgasms among a group of women living in urban Iran. The study addresses the possible consequences and implications of faking orgasms for women’s sexual life. Eleven female participants took part in the study. The data revealed that the topic was considered taboo even among highly educated working women. It also showed that faking orgasms were related to perceived female moral responsibilities and marital self-sacrifice and the lack of sexual education and knowledge, machismo, male infidelity, porn culture, and sexual performance ideals.
Queering Tibetan Buddhism through Vernacular Agency
Authors: Tamburrano Dario 
Published: September 2022

Abstract
This article presents the personal experience narrative of Tashi Choedup (Tib. bkra shis chos grub, ‘They/Them’, b. 1990), an openly queer Buddhist monastic ordained in the Tibetan tradition in India, as a microcosmic reflection of the interaction between a traditional Buddhist conceptualisation of gender and its adaptations to the contemporary understanding of identity. After introducing the classical Buddhist views of gender, I will briefly survey the current orientation of the Tibetan Buddhist leadership between dogmatic legacies and progressive openings. The personal narrative of Tashi Choedup brings a positive account of the ethical shift away from gender variance phobia, also exemplifying the role of vernacular agency in challenging the neatness of the religious institutionalised social arrangement.
Cyclops lesions associated with both bundles and selective bundle repair of the anterior cruciate ligament
Authors: Kim Ji Na , Park Hee Jin , Park Ji Hee , Kim Myung Sub , Park Jai Hyung , Kim Eugene , Park Se Jin , Moon Soonyoung 
Published: September 2022

Background The remnant of a ruptured anterior cruciate ligament (ACL) can increase the risk of impingement or a cyclops lesion, which can increase challenges to proper tunnel placement. Purpose To evaluate the prevalence of cyclops lesions after ACL reconstruction and to assess the difference in the incidence of cyclops lesions between single-bundle repair and selective bundle repair of the ACL. Material and Methods This retrospective study included 151 patients who were diagnosed with an ACL tear after knee joint magnetic resonance imaging (MRI) who underwent ACL reconstruction surgery. MRI diagnosis of cyclops lesion formation was made if a soft-tissue mass was seen anteriorly in the intercondylar notch near the tibial insertion of the reconstructed ACL, based on sagittal T2-weighted (T2W) imaging. The size of the cyclops lesions was recorded as the largest diameter on the sagittal T2W imaging. Results A cyclops lesion was detected in 74 (38.5%) cases. Cyclops lesions were detected more frequently in cases with single-bundle repair of the ACL, but the results were not statistically significant ( P = 0.609). Compared with selective bundle repair, cyclops lesions had a significantly higher prevalence in the posterolateral (PL) bundle repair than in the anteromedial (AM) bundle repair ( P = 0.027) based on MR images at 6–12 months after surgery. Conclusion The incidence of cyclops lesions did not differ significantly in single-bundle repair and selective bundle repair of ACL. However, selective PL bundle repair of the ACL showed a significantly increased incidence of cyclops lesions compared with selective AM bundle repair.