bluuebunny/crossref_metadata_2025_split huggingface dataset:
ONG
Authors: Gebauer Thomas , Wayllace Ana Elia 
Published: May 2022

Les ONG se sont développées au fur et à mesure de la mondialisation néolibérale. Elles ont été amenées à combler en partie le vide laissé par le retrait et la privatisation des États, faisant dès lors l’objet d’instrumentalisations diverses, tant de la part de la sphère politique que du monde des affaires. Une « repolitisation », en lien avec une réévaluation critique de la « société civile », est donc nécessaire.
L’urgence écologique vue du Sud
Authors: Kothari Ashish , Kolinjivadi Vijay , Polet François 
Published: May 2022

Sans mise en cause de l’économie politique de la mondialisation, un Green New Deal ne sera qu’une vitrine occultant la poursuite de l’exploitation de la nature et du travail pour satisfaire la demande « écologique » des fractions privilégiées de l’humanité. Il faut sortir de la logique des transferts de coûts, qui fait porter sur les plus pauvres et l’environnement au Sud, les effets de la tendance à « verdir » un modèle, sans le transformer.
Fuir l’Amérique centrale
Authors: Zúñiga Núñez Mario , Mendoza Carlos , Polet François 
Published: May 2022

Au Salvador, le phénomène des gangs s’inscrit dans l’histoire tourmentée des migrations. Les jeunes ayant migré en Californie dans les années 1980-1990 sont nombreux à avoir intégré l’univers des maras , une réalité ancrée dans la culture de frontière des quartiers populaires à dominante latino-américaine. Le tournant sécuritaire états-unien s’est traduit par une politique d’expulsion qui a contribué à l’exportation de ces gangs en Amérique centrale.
Naturaliser dans l’Empire colonial
Authors: Ben Salah Jihane 
Published: May 2022

Dans le cadre de la gouvernance des sociétés coloniales, reposant sur des démarcations statutaires séparant strictement les populations, la dignité de citoyen – attachée à la procédure de naturalisation – est concédée aux sujets d’Empire dans de rarissimes cas. En 1923, toutefois, les autorités coloniales du protectorat de Tunisie ouvrent l’accès à la nationalité française, tant aux étrangers, essentiellement européens, qu’aux Tunisiens. Le présent article analyse, en croisant méthodes quantitatives et qualitatives, les effets de la loi du 20 décembre 1923 sur le mouvement et la procédure de naturalisation dans la régence de Tunis et rend compte de l’existence d’une singularité tunisienne en la matière.
Nationaliser le ciel
Authors: Vaillot Benoît 
Published: May 2022

Cet article propose d’analyser la transformation de la souveraineté induite par la navigation aérienne au début du 20 e siècle et de démontrer comment le concept de souveraineté aérienne a été pensé, inventé et appliqué pour la première fois à la frontière franco-allemande à la veille de la Première Guerre mondiale, avant sa reconnaissance dans le droit international. Tout d’abord discuté par les juristes, le principe d’une extension de la puissance de l’État à l’atmosphère terrestre est progressivement approprié par les populations en Europe, ce qui conduit les gouvernements à inventer l’espace aérien national.
Improving Confidence in Clinical Assessment Skills Through Service-Learning Experiences Among Nursing Students
Authors: Mumba Mercy Ngosa , Kaylor Sara K. , Townsend Haley , Barron Keri , Andrabi Mudasir 
Published: May 2022

Background:
Service-learning (SL) was incorporated into a nonclinical undergraduate nursing course. This study examined the effects of SL on nursing students' confidence in performing patient health assessments.

Method:
Nursing students completed an experiential SL vital signs assessment and a subsequent reflective journal. Of 112 reflective journals, 30 journals were randomly selected for qualitative analysis to understand the experiences of SL for nursing students. A rapid analytic framework was used for data analysis.

Results:
The following domains were identified: overcoming initial fear, building confidence in clinical assessment skills, practicing therapeutic communication and patient education, and developing problem solving skills.

Conclusion:

This project highlights that SL experiences are not limited only to clinical settings but also are appropriate for nontraditional preclinical settings as well. Such experiences introduce nursing students to patient care and critical reasoning prior to transitioning to subsequent clinical nursing courses.

[
J Nurs Educ
. 2022;61(5):272–275.]
Reducing the Intimidation Factor of Teaching Genetics and Genomics in Nursing
Authors: Mathis Holly C. 
Published: May 2022

Background:
Faculty-related barriers to increasing genetics and genomics content in undergraduate nursing education include knowledge deficits and a limited ability to embrace curricular changes.

Method:
Faculty members at one school of nursing participated in an educational program designed to address these barriers and reduce the intimidation of teaching a challenging topic. Participants' perceptions of changes in their knowledge and confidence, as well as the quantity of potential curricular threads identified by participants were used to evaluate the program.

Results:
All of the participants indicated the program increased their knowledge of genetics and genomics, and the majority (68.2%) of participants reported their confidence in developing curricular content also had increased. Participants identified numerous potential genetics and genomics-related curricular threads, especially regarding nurses' professional responsibilities.

Conclusion:

Faculty education shows promise as a strategy to increase knowledge, confidence, and ability to identify opportunities to increase genetics and genomics content in undergraduate nursing education.

[
J Nurs Educ
. 2022;61(5):261–263.]
La renaissance de la géographie historique en France depuis les années 1990
Authors: Boulanger Philippe 
Published: May 2022

Depuis l’époque moderne, la géographie historique française est une approche évolutive de la géographie. Elle connaît son plein essor surtout du début du XIXe jusqu’au milieu du XXe siècle. Aujourd’hui, un regain d’intérêt se distingue autant dans la communauté des géographes que celles des historiens. Pourquoi la géographie historique est-elle si méconnue alors qu’elle suscite un nouvel intérêt aujourd’hui ?
Origin and the development of primates comparative cytogenetics
Authors: Sineo Luca 
Published: May 2022

Genetic and cytogenetic comparison in between man and non-human primates has largely contributed to the knowledge of the evolution of the Order Primates and in particular of man.
Since Darwin's first intuition about the close relationship of man and apes a growing number of evidences confirmed this hypothesis. More recently in 1956 and later in the 1960s pioneering chromosomal studies defined the correct chromosome number of man and apes. [...]
The organizational model of the Research Unit of Health Professions: the experience at the hospital of Alessandria
Authors: Bolgeo Tatiana , Di Matteo Roberta , Gardalini Menada , Gatti Denise , Maconi Antonio 
Published: May 2022

Aim: Promote and enhance the path created to establish an organizational model of the Research Unit of the Healthcare Professions that is effective for increasing scientific production.
Methods: The benchmarking techniques used make it possible to create a standard of excellence by comparing the performance achieved at the various decision-making levels of the system, evaluating the correct use of resources and, if necessary, undertaking changes in health policies.
Results: Benchmarking activities were carried out in the organizational, training and research areas between the Research Units of the Health Professions present in Italy and adapted to the business context. Training and insertion paths for URPS personnel, activation phases of the company network, insertion of the students of the nursing degree course in clinical studies, collaborations with other bodies, dissemination of engagement and fundraising techniques have been defined.
Conclusions: The defined paths have allowed the establishment of an organizational model of the Research Unit of the Healthcare Professions with the vision of becoming an attractive reference center for nursing research and all Healthcare Professions.
Anaplastic lymphoma kinase fusion protein expression is associated with a favorable prognosis in resected invasive mucinous lung adenocarcinoma
Authors: Wang Jian , Wei Penghua , Liu Jing , Su Peng , Xing Aiyan , Jing Haiyan , Hao Jing 
Published: May 2022

Background:
Invasive mucinous adenocarcinoma (IMA) is a distinct variant of lung adenocarcinoma, which typically has a worse survival. However, its pathogenesis is potentially associated with a high degree of molecular heterogeneity, which might determine its different prognosis.

Methods:
We retrospectively analyzed 2207 consecutive lung adenocarcinoma patients who underwent radical resection at Qilu Hospital of Shandong University and Shandong Provincial Hospital from 2013 to 2019. Anaplastic lymphoma kinase (ALK) fusion protein expression was routinely detected by immunohistochemistry. The clinicopathological characteristics and treatment outcomes of IMA patients were retrieved, and compared between ALK-positive and ALK-negative IMA patients as well as between pure IMA and mixed IMA patients. The last follow-up was on December 31, 2020, and the median follow-up was 42 months.

Results:
A total of 98 patients (4.4%) were diagnosed with IMA. ALK protein expression was positive in 24.5% of IMAs, which was significantly higher than that of non-IMA lung adenocarcinomas (4.7%, P < 0.001). ALK-positive and ALK-negative IMA, as well as pure IMA and mixed IMA, showed similar distribution in terms of patients' age, gender and smoking history, stage, and primary tumor location, except for a higher rate of lymph node metastasis in mixed IMA (22.0% vs. 46.2%, P = 0.012). Five cases (20.8%) of ALK-positive IMAs and 28 cases (40.6%) of ALK-negative IMAs experienced recurrence. Multivariable-adjusted Cox regression analysis demonstrated that ALK expression was a favorable prognostic factor for both disease-free survival (hazard ratio [HR]: 0.354; 95% confidence interval [CI]: 0.131–0.960; P = 0.041) and overall survival (HR: 0.138; 95% CI: 0.029–0.658; P = 0.013) in resected IMA. No difference in disease-free survival (HR: 0.524; 95% CI: 0.237–1.157; P = 0.110) and OS (HR: 0.553; 95% CI: 0.199–1.537; P = 0.256) was observed between pure IMA and mixed IMA.

Conclusion:
Invasive mucinous lung adenocarcinoma showed higher ALK protein expression, which was a favorable prognostic factor for survival in early resected patients.
Pantoprazole promotes the sensitivity of cervical cancer cells to cisplatin by inhibiting cisplatin-induced autophagy
Authors: Su Guangzhu , Chen Xiaolu , Yang Hongyan 
Published: May 2022

Aim:
This study aimed to explore the role of pantoprazole (PPZ) in affecting the sensitivity of cervical cancer (CC) cells to cisplatin.

Methods:
HeLa and CaSki cells were exposed to cisplatin and/or PPZ treatment. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, colony formation, flow cytometry, wound healing, and transwell assays were performed to detect cell viability, proliferation, apoptosis, migration, and invasion of CC cells, respectively. Then, expressions of Beclin-1, LC3, and p62 were measured by western blot. Rapamycin (Rapa), acting as an autophagy activator, was applied to confirm the effect of autophagy on the sensitivity of CC cells to cisplatin.

Results:
Cisplatin treatment suppressed cell viability and proliferation and accelerated apoptosis of CC cells. Combination of cisplatin and PPZ or PPZ alone significantly inhibited cell viability, proliferation, migration, and invasion, and increased cell apoptosis of CC cells. Cisplatin enhanced expression levels of Beclin1 and LC3II/I, and reduced p62 expression. Combination of cisplatin and PPZ significantly decreased the expression levels of Beclin1 and LC3II/I, but increased p62 expression. The autophagy activator, Rapa, eliminated the inhibitory effects of the combination of cisplatin and PPZ on autophagy, and enhanced cell viability, but inhibited apoptosis of CC cells.

Conclusion:
PPZ promotes the sensitivity of CC cells to cisplatin by inhibiting cisplatin-induced cell autophagy.
Norcantharidin alleviates cyclophosphamide induced immunosuppression and leukopenia in mice through NF κB pathway
Authors: Wang Guochuan , Zhou Xiaolu , Yang Mei , Ma Xiaoyu , Liu Xin 
Published: May 2022

Purpose: To investigate the effect of norcantharidin (NCTD) on cyclophosphamide (CY)-induced immunosuppression and leukopenia in mice.
Methods: Cyclophosphamide (80 mg/kg/day) was intraperitoneally administered to mice from day 1 to 3 and day 9, and from day 4 to 10, NCTD (1, 2 and 4 mg/kg) was intraperitoneally administered. The counts of white blood cells (WBC), red blood cells (RBC) and platelets (PLT) in peripheral blood were determined, followed by the evaluation of mouse spleen and thymus indices. Histopathological examination was performed using hematoxylin-eosin (H & E) staining. In addition, the serum levels of immunoglobulins and cytokines were determined using enzyme-linked immunosorbent assay (ELISA), while plenetic T lymphocyte subsets were assessed by flow cytometry. The expression levels of p65, p-p65, IκBα, and p-IκBα in spleen tissues were determined by immunoblotting.
Results: Administration of NCTD (1, 2 and 4 mg/kg) increased blood cell counts, and alleviated injuries on splenocytes and thymocytes in CY-treated mice, accompanied by decline in spleen and thymus indices. NCTD ameliorated CY-induced immunosuppression by inhibiting the cytokines but increased the immunoglobulins. CD4+ and CD8+ T lymphocyte expressions were enhanced, especially at the high dose of NCTD (4 mg/kg). Besides, NCTD at high doses (2 and 4 mg/kg) significantly activated NF-κB pathway.
Conclusion: Administration of NCTD alleviates CY-induced leukopenia and immunosuppression in mice through activation of NF-κB pathway, thus providing a lead for the potential treatment of chemotherapy-induced leukopenia and immunosuppression.
Effect of amifostine on pulmonary contusion from blunt chest trauma in rats
Authors: Acıpayam Ahmet , Eser Nadire , Yaylalı Aslı Eryılmaz , Tülüce Kerim , Yoldaş Atilla , Tolun Fatma İnanç 
Published: May 2022

Purpose: To investigate the efficacy of different doses of amifostine (AMI) and dexamethasone (DXM) on bilateral pulmonary contusion in rats.
Methods: Forty-two Sprague Dawley rats were divided into six groups of seven animals each (control, pulmonary contusion (PC), PC + AMI 400 mg/kg, PC + AMI 200 mg/kg, PC + AMI 400 mg/kg + DXM, and PC + DXM-treated groups). RelAssay commercial kit was used to determine total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). Nitric oxide (NO), inducible nitric oxide synthase (iNOS), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) activity associated with blunt trauma induced pulmonary damage were determined by enzyme-linked immunosorbent assay (ELISA). Blood gas was determined using a blood gas analyzer, while histopathological examinations were performed on the tissues by hematoxylin and eosin (H & E) staining method.
Results: Significant improvement in biochemical parameters and histopathological findings were observed in the groups treated with dexamethasone and high-dose amifostine (400 mg/kg; p < 0.05). However, low-dose amifostine (200 mg/kg) and a combination of dexamethasone with amifostine (400 g/kg) was ineffective in balancing the biochemical changes due to trauma (p > 0.05).
Conclusion: High-dose amifostine combined with dexamethasone mitigates trauma-induced damage in rat by preventing the elevation of key inflammatory markers. Further preclinical and clinical studies are required to determine the efficacy of amifostine in humans and to compare its activity with other agents.
KLK4 affects the biological behavior of oral squamous cell carcinoma through Wnt/β catenin and PI3K/Akt signaling pathways
Authors: Fang Yihong , Ouyang Qiming , Zheng Zhi , Wang Jin 
Published: May 2022

Purpose: To investigate the effect of kallikrein 4 (KLK4) on oral squamous cell carcinoma (OSCC), and its mechanism of action.
Method: Human tongue SCC cell line TCA-8113 was cultured, and the interference fragment and irrelevant sequence fragment of KLK4 gene were designed and synthesized. These fragments were constructed into pgcsi-h1 plasmid. Then, the TCA-8113 cells were cultured for 24 h, followed by transfection, after which TCA-8113-NC and TCA-8113-siKLK4 cells were obtained. The mRNA expression of KLK4 was determined using quantitative real-time-polymerase chain reaction (PCR). Proliferative potential was assessed using MTT method, while apoptosis was determined by flow cytometry. Furthermore, cell migration was evaluated by scratch test, and Transwell cell invasion experiment was used to determine cell invasion. Immunoblot assay was applied to determine the expressions of E- and N-cadherins, vimentin, uPA, Wnt1, β-Catenin, p-pi3k and p-Akt.
Result: Compared with TCA-8113-nc, the expression of KLK4 in TCA-8113-siKLK4 cells was significantly down-regulated, while, relative to TCA-8113-NC, TCA-8113-siKLK4 cells had significantly reduced cell proliferation, invasion and migration, and enhanced apoptosis (p < 0.05). Moreover, there was significant up-regulation of E- and N-cadherins, vimentin, uPA, Wnt1, β-Catenin, p-pi3k and p-Akt in TCA-8113-siKLK4 group, relative to TCA-8113-NC (p < 0.05).
Conclusion: KLK4 enhances the multiplication, metastasis and invasive potential of OSCC cells, but suppresses apoptotic changes via activation of Wnt/β-catenin/PI3K/Akt signal route. The potential of Kallikrein-4 as biomarker for OSCC cells should be determined in suitable animal models.
Determination of allyl isothiocyanate from Hedyotis herbacea and its in silico screening for wound healing activity
Authors: Babu K Anand , Sivakrishnan S , Jasemine S 
Published: May 2022

Purpose: To determine the bio-active constituents from the chloroform leaf extract of Hedyotis herbacea, and the wound healing activity of its phytoconstituents.
Methods: A gas chromatographic-mass spectrophotometer (GC-MS) was used to isolate and characterize the plant’s chloroform extract. In order to verify the effectiveness of the isolated allyl isothiocyanate, it was docked with key enzymes needed for the healing process of wounds, such as p50 NF-κB, Interleukin-6 (IL-6), COX-2, TNF-α, Interleukin-1β, MMP-9, FGF-2, FGF2/FGF2-FGFR1, IGF1R, and TGF-β1 by using AUTODOCK VINA.
Results: The GC-MS isolated and identified 425 compounds in the screened extract, out of which 29 compounds were shown to have significant pharmacological activity. The allyl isothiocyanate compound present in the extract was shown to have the ability to repair skin damage. In silico analysis revealed that allyl isothiocyanate interacts efficiently with the active site of residues of amino acids found in the crucial proteins which are involved in wound healing process.
Conclusion: Hedyotis herbacea contains allyl isothiocyanate, which has wound-healing properties. Other unexplored phytocompounds in the extract might also contribute to the wound-healing activity of the plant. This should be further evaluated in order to access more wound-healing properties of the plant.
Effect of general anesthesia with different doses of remimazolam on the depth of sedation and respiratory function in patients
Authors: Liu Zhijie , Zhao Xing , Chen Yongxue , Gao Yang 
Published: May 2022

Purpose: To investigate the effect of general anesthesia using different doses of remimazolam on the depth of sedation and respiratory function in patients.
Methods: From August 2019 to May 2021, 120 patients admitted to Handan Central Hospital for general anesthesia were randomly assigned to propofol group (positive control) given the drug at a dose of 1.5 mg/kg, and three groups were given remimazolam (R) at a dose of 0.2 mg/kg (R1), 0.3 mg/kg (R2), or 0.4 mg/kg (R3) via intravenous injection. relation between Modified Observer Alertness/Sedation Scale (MOAA/S) scores and BIS was determined and recorded for the three remimazolam groups of patients. Systolic blood pressure, diastolic blood pressure, heart rate and oxygen saturation (SpO2) levels were recorded. The Bruggrmann Comfort Scale (BCS) scale [8] was used at 4 score grades to assess the comfort level of the patients.
Results: The Modified Observer Alertness/Sedation Scale (MOAA/S) scores were positively correlated with Bispectral index (BIS); the higher the anesthesia dose, the higher the MOAA/S scores and BIS values of the patients. Patients in groups R1, R2, and R3 had significantly higher systolic blood pressure, diastolic blood pressure, heart rate, and oxygen saturation (SpO2) at T2 than those in the propofol group (p < 0.05). Groups R1 and R2 exhibited considerably greater PAW values at T3 than the propofol group, whereas R3 had significantly lower PAW values at T3. There was significantly more incidence of bradycardia and hypotension in the propofol group than in the other three groups (p < 0.05).
Conclusion: General anesthesia with remimazolam at a dose of 0.3 mg/kg has no effect on respiratory function and hemodynamics, but it produces positive sedation and a high safety profile. However, more clinical trials are necessary prior to its application in clinical practice.
Patients’ satisfaction with treatment using anti rheumatic drugs, and their adherence to medication: A non interventional, cross sectional study among some Chinese outpatients
Authors: Zhang Huying , Gu Yurong , Chen Lu , Zhu Jinwei , Luo Chao , Zhou Weijun 
Published: May 2022

Purpose: To determine satisfaction with treatment and adherence to medication amongst Chinese patients with rheumatoid arthritis.
Methods: This cross-sectional study enrolled 398 rheumatoid arthritis (RA) patients who filled out questionnaire during outpatient consultation. The Chinese version of the Treatment Satisfaction Questionnaire (C-TSQM-II) was used to evaluate treatment satisfaction, while the Chinese Compliance Questionnaire for Rheumatology (threshold ≤ 80) and the medication possession ratio (MPR) were used for the assessment of adherence to medication.
Results: In all medications, treatment satisfaction was higher in the mild subgroup and the moderate subgroup than in the severe subgroup (p < 0.05). Treatment satisfaction scores with respect to biological disease-modifying anti-rheumatic drugs (bDMARDs) were significantly lower in patients in the severe subgroup than in those in the moderate subgroup, with respect to convenience and global satisfaction (p < 0.05). Moreover, for bDMARDs therapies, treatment satisfaction was higher in the moderate subgroup than in the severe subgroup in all four areas examined (p < 0.05). The Chinese Compliance Questionnaire score showed that 156 patients (39 %) were adherent to medication, while 242 patients (61 %) were not. Results from MPR indicate that 310 patients (78 %) were adherent to medication, while 68 patients (22 %) were not. In the mild group, 96.5 % of patients were adherent to all medications, and 94.4 % were adherent to bDMARDs.
Conclusion: Patients were most likely unable to distinguish amongst disease progression, disease-induced damage, and other causes of pain or discomfort. Treatment satisfaction and medication adherence were higher in patients with mild rheumatoid arthritis.