bluuebunny/crossref_metadata_2025_split huggingface dataset:
FlexParser—The adaptive log file parser for continuous results in a changing world
Authors: Rücker Nadine , Maier Andreas 
Published: January 2022

AbstractAny modern system writes events into files, called log files. Those contain crucial information which are subject to various analyses. Examples range from cybersecurity, intrusion detection over usage analyses to trouble shooting. Before data analysis is possible, desired information needs to be extracted first out of the semi‐structured log messages. State‐of‐the‐art event parsing often assumes static log events. However, any modern system is updated consistently and with updates also log file structures can change. We call those changes “mutation” and study parsing performance for different mutation cases. Latest research discovers mutations using anomaly detection post mortem, however, does not cover actual continuous parsing. Thus, we propose a novel and flexible parser, calledFlexParser, which can extract desired values despite gradual changes in the log messages. It implies basic text preprocessing followed by a supervised Deep Learning method. We train a stateful LSTM on parsing one event per data set. Statefulness enforces the model to learn log message structures across several examples. Our model was tested on seven different, publicly available log file data sets and various kinds of mutations. Exhibiting an average F1‐Score of 0.98, it outperforms other Deep Learning methods as well as state‐of‐the‐art unsupervised parsers.
A facile, scalable, high stability Lithium metal anode
Authors: Zhao Qiang , Chen Xin , Hou Wang , Ye Beirong , Zhang Yongqi , Xia Xinhui , Wang Jinshu 
Published: January 2022

AbstractLi has garnered enormous attention for next‐generation Li metal batteries owing to its remarkable theoretical capacity. Unfortunately, as an anode, Li suffers from serious safety issues and fast capacity fading due to the formation of Li dendrites, which hinders the practical application of Li anode. Herein, a LiAlO2‐PVDF composite modification layer is fabricated on the surface of Li metal to enhance its stability and electrochemical performance. Benefitting from the synergetic effects of high Li+ conductivity, high Li+ transference number, excellent mechanical properties, superior chemical durability, and compactness of the modification layer, the LiAlO2‐PVDF@Li electrode delivers an ultra‐long lifespan and a high capacity retention rate in the LiAlO2‐PVDF@Li│LiFePO4 full cell. The proposed strategy provides a new alternative anode for Li metal batteries with high performance and scalable production.
Surgical correction of feline uterine prolapse
Authors: de Lima Alexandria , Wickramasinghe Chandika 
Published: January 2022

AbstractA female domestic shorthair cat of unknown age, weighing 2.9 kg, was presented with a single horn of the uterus protruding through the vulva. The cat had a history of recent parturition, delivering four kittens, and was mildly dehydrated and generally stable. The exposed uterine tissue was congested and oedematous, with areas of devitalization and necrosis. Manual reduction of the prolapsed uterus was unsuccessful because of severe oedema. The protruding uterus was amputated, and a midline laparotomy was performed for staged ovariohysterectomy. Postoperatively, the cat appeared healthy with no vulval discharge and no recurrence of clinical signs. This case report demonstrates the different methods involved in the correction of a uterine prolapse.
The gluon Regge trajectory at three loops from planar Yang-Mills theory
Authors: Del Duca Vittorio , Marzucca Robin , Verbeek Bram 
Published: January 2022

Abstract
We compute the three-loop leading-colour corrections to the Yang-Mills Regge trajectory and gluon impact factor. Conjecturing that, in analogy with $$ \mathcal{N} $$
N
= 4 super Yang-Mills (SYM), in a suitable scheme Nc-subleading terms are absent from the three-loop Regge trajectory, we understand our result as the first computation of the pure gauge, or nf = 0, part of the QCD three-loop Regge trajectory. The results are presented both for the bare and renormalised amplitudes and are consistent with predictions from infrared factorisation along with reproducing known results in planar $$ \mathcal{N} $$
N
= 4 SYM through a maximal weight truncation. We also include the dependence on a Regge factorisation scale to facilitate future applications in BFKL theory at next-to-next-to leading logarithmic accuracy.
Amino Acid Specificity of Ancestral Aminoacyl-tRNA Synthetase Prior to the Last Universal Common Ancestor Commonote commonote
Authors: Furukawa Ryutaro , Yokobori Shin-ichi , Sato Riku , Kumagawa Taimu , Nakagawa Mizuho , Katoh Kazutaka , Yamagishi Akihiko 
Published: January 2022

Abstract
Extant organisms commonly use 20 amino acids in protein synthesis. In the translation system, aminoacyl-tRNA synthetase (ARS) selectively binds an amino acid and transfers it to the cognate tRNA. It is postulated that the amino acid repertoire of ARS expanded during the development of the translation system. In this study we generated composite phylogenetic trees for seven ARSs (SerRS, ProRS, ThrRS, GlyRS-1, HisRS, AspRS, and LysRS) which are thought to have diverged by gene duplication followed by mutation, before the evolution of the last universal common ancestor. The composite phylogenetic tree shows that the AspRS/LysRS branch diverged from the other five ARSs at the deepest node, with the GlyRS/HisRS branch and the other three ARSs (ThrRS, ProRS and SerRS) diverging at the second deepest node. ThrRS diverged next, and finally ProRS and SerRS diverged from each other. Based on the phylogenetic tree, sequences of the ancestral ARSs prior to the evolution of the last universal common ancestor were predicted. The amino acid specificity of each ancestral ARS was then postulated by comparison with amino acid recognition sites of ARSs of extant organisms. Our predictions demonstrate that ancestral ARSs had substantial specificity and that the number of amino acid types amino-acylated by proteinaceous ARSs was limited before the appearance of a fuller range of proteinaceous ARS species. From an assumption that 10 amino acid species are required for folding and function, proteinaceous ARS possibly evolved in a translation system composed of preexisting ribozyme ARSs, before the evolution of the last universal common ancestor.
Affective lability and social functioning in severe mental disorders
Authors: Høegh Margrethe Collier , Melle Ingrid , Aminoff Sofie R. , Olsen Stine Holmstul , Lunding Synve Hoffart , Ueland Torill , Lagerberg Trine Vik 
Published: January 2022

AbstractSocial functioning is impaired in severe mental disorders despite clinical remission, illustrating the need to identify other mechanisms that hinder psychosocial recovery. Affective lability is elevated and associated with an increased clinical burden in psychosis spectrum disorders. We aimed to investigate putative associations between affective lability and social functioning in 293 participants with severe mental disorders (schizophrenia- and bipolar spectrum), and if such an association was independent of well-established predictors of social impairments. The Affective Lability Scale (ALS-SF) was used to measure affective lability covering the dimensions of anxiety-depression, depression-elation and anger. The interpersonal domain of the Social Functioning Scale (SFS) was used to measure social functioning. Correlation analyses were conducted to investigate associations between affective lability and social functioning, followed by a hierarchical multiple regression and follow-up analyses in diagnostic subgroups. Features related to premorbid and clinical characteristics were entered as independent variables together with the ALS-SF scores. We found that higher scores on all ALS-SF subdimensions were significantly associated with lower social functioning (p < 0.005) in the total sample. For the anxiety-depression dimension of the ALS-SF, this association persisted after controlling for potential confounders such as premorbid social functioning, duration of untreated illness and current symptoms (p = 0.019). Our results indicate that elevated affective lability may have a negative impact on social functioning in severe mental disorders, which warrants further investigation. Clinically, it might be fruitful to target affective lability in severe mental disorders to improve psychosocial outcomes.
Quantifying test-retest reliability of repeated objective attentional measures in Lewy body dementia
Authors: Elder Greg J. , Colloby Sean J. , Firbank Michael J. , Taylor John-Paul 
Published: January 2022

AbstractObjective cognitive impairment is a feature of Lewy body dementia (LBD), and computerised attentional tasks are commonly used as outcome measures in interventional trials. However, the reliability of these measures, in the absence of interventions, are unknown. This study examined the reliability of these attentional measures at short-term and longer-term follow-up stages. LBD patients (n = 36) completed computerised attentional tasks [simple and choice reaction time, and digit vigilance (SRT, CRT, DV)] at short-term (Day 0–Day 5) and longer-term (4 and 12 weeks) follow-up. Intra-class correlations (ICCs) were calculated to assess test–retest reliability. At short-term, the reciprocal SRT, CRT and DV mean reaction time to correct answers, the reciprocal DV coefficient of variation, and reciprocal power of attention (PoA) all showed excellent levels of reliability (all ICCs > 0.90). The reciprocal PoA showed the highest level of reliability (ICC = 0.978). At longer-term follow-up, only the reciprocal PoA had excellent levels of reliability (ICC = 0.927). Reciprocal SRT, CRT and DV reaction time to correct answers, and the CRT coefficient of variation values, showed good levels of test–retest reliability (ICCs ≥ 0.85). Contrary to expectations, most attentional measures demonstrated high levels of test–retest reliability at both short-term and longer-term follow-up time points. The reciprocal PoA composite measure demonstrated excellent levels of test–retest reliability, both in the short-term and long-term. This indicates that objective attentional tasks are suitable outcome measures in LBD studies and that the composite PoA measure may offer the highest levels of reliability.
Anchorless risk or released benefit? An updated view on the ADAM10-mediated shedding of the prion protein
Authors: Mohammadi Behnam , Song Feizhi , Matamoros-Angles Andreu , Shafiq Mohsin , Damme Markus , Puig Berta , Glatzel Markus , Altmeppen Hermann Clemens 
Published: January 2022

AbstractThe prion protein (PrP) is a broadly expressed glycoprotein linked with a multitude of (suggested) biological and pathological implications. Some of these roles seem to be due to constitutively generated proteolytic fragments of the protein. Among them is a soluble PrP form, which is released from the surface of neurons and other cell types by action of the metalloprotease ADAM10 in a process termed ‘shedding’. The latter aspect is the focus of this review, which aims to provide a comprehensive overview on (i) the relevance of proteolytic processing in regulating cellular PrP functions, (ii) currently described involvement of shed PrP in neurodegenerative diseases (including prion diseases and Alzheimer’s disease), (iii) shed PrP’s expected roles in intercellular communication in many more (patho)physiological conditions (such as stroke, cancer or immune responses), (iv) and the need for improved research tools in respective (future) studies. Deeper mechanistic insight into roles played by PrP shedding and its resulting fragment may pave the way for improved diagnostics and future therapeutic approaches in diseases of the brain and beyond.
Sensorimotor adaptation in VR: magnitude and persistence of the aftereffect increase with the number of interactions
Authors: Wähnert Svetlana , Gerhards Alexander 
Published: January 2022

AbstractIn both prism and virtual reality experiments, it has been observed that visual displacement leads to an adaptation of the sensorimotor system. A characteristic of adaptation is the occurrence of the aftereffect, which is the spatial deviation of the movements in the direction opposite to the visual displacement. Prism adaptation experiments have shown that a higher number of interactions lead to an increased magnitude and persistence of the aftereffect. The aim of the present study was to investigate this relationship in virtual reality. After baseline measurement, the virtual environment was displaced visually. During this adaptation phase, the participants performed either zero, five, or thirty-five pointing movements. Afterwards, all participants performed the pointing movements without the visual displacement in the virtual environment. Performing five pointing movements during the adaptation phase was already sufficient to produce an aftereffect. With thirty-five pointing movements, both magnitude and persistence of the aftereffect increased. These results replicate studies of prism adaptation. Considering this, we briefly discuss the suitability of virtual reality as a research tool to study prism adaptation.
Modelling of adsorption technologies for controlling indoor air quality
Authors: Grande Carlos A. 
Published: January 2022

AbstractTechnologies for control of indoor air quality are very important to ensure that health and comfort conditions are attained in closed environments. The indoor air quality market is fertile ground for adsorption technologies, both at larger industrial scale and for residential uses. The common strategy to design adsorption technologies considers constant inlet conditions, while for most indoor air control applications, the inlet conditions will change because of the partial removal of the contaminant. This work presents a generic modelling approach, where the adsorption technology is coupled with the indoor environment to be controlled. This approach enables a tailored and more accurate process design and additionally, it can also assist in the physical location of the removal unit and sensors to control its operation. Two different examples of application of this methodology are provided: control of CO2 in tightly closed environments and "peak shaving" of water vapor in bathrooms.
A station-data-based model residual machine learning method for fine-grained meteorological grid prediction
Authors: Zhou Chuansai , Li Haochen , Yu Chen , Xia Jiangjiang , Zhang Pingwen 
Published: January 2022

AbstractFine-grained weather forecasting data, i.e., the grid data with high-resolution, have attracted increasing attention in recent years, especially for some specific applications such as the Winter Olympic Games. Although European Centre for Medium-Range Weather Forecasts (ECMWF) provides grid prediction up to 240 hours, the coarse data are unable to meet high requirements of these major events. In this paper, we propose a method, called model residual machine learning (MRML), to generate grid prediction with high-resolution based on high-precision stations forecasting. MRML applies model output machine learning (MOML) for stations forecasting. Subsequently, MRML utilizes these forecasts to improve the quality of the grid data by fitting a machine learning (ML) model to the residuals. We demonstrate that MRML achieves high capability at diverse meteorological elements, specifically, temperature, relative humidity, and wind speed. In addition, MRML could be easily extended to other post-processing methods by invoking different techniques. In our experiments, MRML outperforms the traditional downscaling methods such as piecewise linear interpolation (PLI) on the testing data.
Effectiveness of digital education shifting model on high school students’ engagement
Authors: Aldhafeeri Fayiz M. , Alotaibi Asmaa A. 
Published: January 2022

Abstract
Digital learning has often been criticized due to its lack of student engagement, which results from the physical absence of teachers and the lack of direct communication with their students. Critics of digital education have also pointed out that students’ disengagement is a major factor behind this education format’s inability to positively impact all stakeholders. This can be frustrating for the students themselves and may result in poor educational outcomes. Therefore, digital learning is regarded as a temporary arrangement and not a potential replacement for face-to-face education because of shortcomings that can lead to disengagement among students. To test the validity of this belief, we conducted an experimental study on 245 female Kuwaiti students. We trained teachers in the digital education shifting (DES) model. Following this model, we placed emphasis on student–teacher communication, cooperation among students, and enhanced the principles of digital learning. We asked the trained teachers’ students to respond to a self-assessed student engagement checklist survey to measure their engagement during online classes. We found that the students of the experimental group performed better on various parameters of observable and internal engagement compared to control group students. Contrary to general belief, we proved that the innovative DES approach can indeed make digital learning more engaging, effective, and a viable alternative or at least an aligned and integrated form for conventional education in the long run.
COVID-19 and mental health: a longitudinal population study from Norway
Authors: Hvide Hans K. , Johnsen Julian 
Published: January 2022

AbstractExisting research has found adverse short-term effects of the COVID-19 pandemic on mental health, but longer-term effects have been less documented. Using newly released register data on all general practitioner consultations in Norway through 2020 (about 14 million consultations in total), we find that during the spring and early summer 2020, the number of psychological cases initially increased relative to prior years, but then fell back towards the level of prior years during the summer 2020. In early September 2020, the number of cases accelerated, a pattern that held up through December 2020, so that the gap between 2020 and prior years became largest end-of-year. Our findings suggest that the accumulated adverse effects of the COVID-19 pandemic on mental health far exceeds the short-term effects. The effects are particularly strong for females and for residents in urban areas.
Distribution of orbits of geometrically finite groups acting on null vectors
Authors: Tamam Nattalie , Warren Jacqueline M. 
Published: January 2022

AbstractWe study the distribution of non-discrete orbits of geometrically finite groups in$${\text {SO}}(n,1)$$SO(n,1)acting on$${\mathbb {R}}^{n+1}$$Rn+1, and more generally on the quotient of$${\text {SO}}(n,1)$$SO(n,1)by a horospherical subgroup. Using equidistribution of horospherical flows, we obtain both asymptotics for the distribution of orbits for the action of general geometrically finite groups, and we obtain quantitative statements with additional assumptions.
Clinical Outcome and Underlying Genetic Cause of Functional Terminal Complement Pathway Deficiencies in a Multicenter UK Cohort
Authors: Shears Annalie , Steele Cathal , Craig Jamie , Jolles Stephen , Savic Sinisa , Hague Rosie , Coulter Tanya , Herriot Richard , Arkwright Peter D. 
Published: January 2022

Abstract
Background
Terminal complement pathway deficiencies often present with severe and recurrent infections. There is a lack of good-quality data on these rare conditions. This study investigated the clinical outcome and genetic variation in a large UK multi-center cohort with primary and secondary terminal complement deficiencies.

Methods
Clinicians from seven UK centers provided anonymised demographic, clinical, and laboratory data on patients with terminal complement deficiencies, which were collated and analysed.

Results
Forty patients, median age 19 (range 3–62) years, were identified with terminal complement deficiencies. Ten (62%) of 16 patients with low serum C5 concentrations had underlying pathogenic CFH or CFI gene variants. Two-thirds were from consanguineous Asian families, and 80% had an affected family member. The median age of the first infection was 9 years. Forty-three percent suffered meningococcal serotype B and 43% serotype Y infections. Nine (22%) were treated in intensive care for meningococcal septicaemia. Two patients had died, one from intercurrent COVID-19. Twenty-one (52%) were asymptomatic and diagnosed based on family history. All but one patient had received booster meningococcal vaccines and 70% were taking prophylactic antibiotics.

Discussion
The genetic etiology and clinical course of patients with primary and secondary terminal complement deficiency are variable. Patients with low antigenic C5 concentrations require genetic testing, as the low level may reflect consumption secondary to regulatory defects in the pathway. Screening of siblings is important. Only half of the patients develop septicaemia, but all should have a clear management plan.
Accuracy of a point-of-care blood lactate measurement device in a prehospital setting
Authors: Walther Louise Houlberg , Zegers Floor , Nybo Mads , Mogensen Christian Backer , Christensen Erika Frischknecht , Lassen Annmarie Touborg , Mikkelsen Søren 
Published: January 2022

AbstractPoint-of-care blood lactate is a promising prognostic biomarker of short-term mortality risk. Portable lactate meters need validation in the prehospital setting before widespread implementation and it is unknown whether the mode of sampling (arterial, capillary or venous) matters. This study aims to compare the StatStrip Xpress Lactate Meter’s (SSX) accuracy to a validated blood gas analyser, ABL90 FLEX (ABL90), in arterial samples in the prehospital environment and to determine if lactate levels measured in venous and capillary blood samples are sufficiently accurate compared to arterial lactate levels. Patients with arterial samples drawn by the prehospital anaesthesiologist for any reason were eligible for inclusion. Simultaneously, three blood samples (arterial, capillary and venous) were analysed on SSX and arterial blood on ABL90. Measurements of agreements were evaluated by Lin’s concordance correlations coefficient (CCC) and Bland–Altman Plots. One-hundred-and-eleven patients were included. SSX showed good accuracy compared to ABL90 in arterial samples with a CCC of 0.92 (95% CI 0.90–0.94). Compared to the arterial samples measured on ABL90, venous samples analysed on SSX showed higher agreement than capillary samples analysed on SSX with CCCs of 0.88 (95% CI 0.85–0.91) and 0.79 (95% CI 0.72–0.85), respectively. Bland–Altman plots showed that SSX lactate measurements in arterial, venous and capillary blood samples all had systematically negative biases compared to ABL90. We conclude that the SSX is accurate in our prehospital setting. Venous samples should be preferred over capillary samples, when arterial samples cannot be obtained.