bluuebunny/crossref_metadata_2025_split huggingface dataset:
HKLL for the non-normalizable mode
Authors: Bhattacharjee Budhaditya , Krishnan Chethan , Sarkar Debajyoti 
Published: December 2022

AbstractWe discuss various aspects of HKLL bulk reconstruction for the free scalar field in AdSd+1. First, we consider the spacelike reconstruction kernel for the non-normalizable mode in global coordinates. We construct it as a mode sum. In even bulk dimensions, this can be reproduced using a chordal Green’s function approach that we propose. This puts the global AdS results for the non-normalizable mode on an equal footing with results in the literature for the normalizable mode. In Poincaré AdS, we present explicit mode sum results in general even and odd dimensions for both normalizable and non-normalizable kernels. For generic scaling dimension ∆, these can be re-written in a form that matches with the global AdS results via an antipodal mapping, plus a remainder. We are not aware of a general argument in the literature for dropping these remainder terms, but we note that a slight complexification of a boundary spatial coordinate (which we call aniϵprescription) allows us to do so in cases where ∆ is (half-) integer. Since the non-normalizable mode turns on a source in the CFT, our primary motivation for considering it is as a step towards understanding linear wave equations in general spacetimes from a holographic perspective. But when the scaling dimension ∆ is in the Breitenlohner-Freedman window, we note that the construction has some interesting features within AdS/CFT.
Risikofaktoren für Schließungen von neonatologischen und pädiatrischen Stationen in nosokomialen Ausbrüchen
Authors: Edler Romy , Chhatwal Patrick , Albrecht Urs-Vito , Vonberg Ralf-Peter 
Published: December 2022

Zusammenfassung
Hintergrund
Im Fall eines nosokomialen Ausbruchs (NA) in der Pädiatrie und Neonatologie wird neben einer Vielzahl weiterer Maßnahmen mintunter die gesamte Station für Neuaufnahmen geschlossen. Dies ist infektionsprophylaktisch zwar oft effektiv, jedoch ökonomisch oft auch sehr nachteilig. Wichtig sind daher Kenntnisse darüber, wann eine solche Schließung sehr wahrscheinlich unvermeidbar ist, um diese dann frühestmöglich durchzuführen.

Ziel der Arbeit
Ermittlung von Charakteristika, die eine Schließung letztlich wahrscheinlich machen.

Material und Methoden
Systematische Literaturrecherche der Worldwide Outbreak Database und weiterer internationaler Datenbanken zu NA mit und ohne Schließung.

Ergebnisse
Es wurden 198 NA aus der Pädiatrie (darunter 25 NA mit und 173 NA ohne Schließung) sowie weitere 413 NA aus der Neonatologie (darunter 52 NA mit und 361 NA ohne Schließung) eingeschlossen. In 446 dieser 611 NA waren auch Intensivstationen (ITS) betroffen. Insgesamt waren 16.107 Patienten betroffen und es ereigneten sich 3155 Infektionen mit 1542 Todesfällen. Die Gesamtdauer der NA betrug dabei 2 bis 4380 Tage; sofern erfolgt, betrug die Dauer der Schließung 2 bis 210 Tage. Die am häufigsten nachgewiesenen Erreger in Ausbrüchen mit Schließung waren S. marcescens, E. cloacae und K. pneumoniae. Die Beteiligung einer ITS sowie hohe Fallzahlen korrelierten signifikant mit der Wahrscheinlichkeit für eine spätere Schließung.

Diskussion
Insbesondere für die Neonatologie wird bei der Beteiligung einer ITS an einem NA empfohlen, eine Schließung des Bereiches frühzeitig zu erwägen. Zudem kann in NA die Definition lokal festgelegter Schwellenwerte für Patientenzahlen, bei deren Überschreiten bestimmte Hygienemaßnahmen, wie z. B. die Schließung der Station, initiiert werden, sinnvoll sein.
Design of a compliant device for peg-hole separation in robotic disassembly
Authors: Su Shizhong , Pham Duc Truong , Ji Chunqian , Wang Yongjing , Huang Jun , Zhou Wei , Wang Haolin 
Published: December 2022

AbstractDisassembly is the first step in the remanufacturing of a product. This paper presents the design of a robot end-of-arm tool for removing a peg from a hole, a common operation in the disassembly of mechanical products. The device is a compliant structure that enables the peg to be pulled out of a closely fitting hole without jamming or wedging. The device is reminiscent of the Remote Centre Compliance (RCC) mechanism used by assembly robots to insert cylindrical pegs into cylindrical holes with small clearances. However, whereas the RCC mechanism has primarily to withstand compressive forces, the proposed compliant device must resist tensile forces because of the nature of disassembly operations. The paper details a finite-element modelling study of peg removal with and without using the compliant structure. The results obtained show that the structure markedly reduces the stresses at the points of contact between the peg and the hole and, consequently, the risk of damage to the components being disassembled.
Partnership, sexuality, and fertility-related communication: findings from a register-based study among long-term hematological cancer survivors
Authors: Lohmann Britta , Kuba Katharina , Götze Heide , Mehnert-Theuerkauf Anja , Heyne Svenja , Esser Peter 
Published: December 2022

Abstract

Purpose
Even though the number of hematological cancer survivors suffering from long-term and late consequences of their disease is growing, knowledge about their situation regarding partnership, sexuality, and fertility-related communication is sparse to date.

Methods
We recruited survivors of hematological malignancies (≥ 3 years after diagnosis) from two cancer registries in Germany. We applied validated instruments and study-specific items on satisfaction with partnership, sexual functioning, and fertility-related communication with physicians. We provided descriptive statistics and conducted multiple regression analyses to identify associations of the outcomes with patient factors and well-being (anxiety, depression, and quality of life).

Results
Of 2001 eligible survivors, 922 (46%) participated. Fifty-seven percent were male, and the mean age was 64 years. Ninety percent and 60% reported to be satisfied with their partnership and sexual life, respectively. However, 81% and 86% reported being sexually impaired by physical or mental symptoms, respectively. Seventy-four percent of those with incomplete family planning had a fertility-related conversation with a physician. Female gender (p < .05, Beta =  − .09), older age (p < .01, Beta = .10), and chemotherapy (p < .01, Beta = .10) were associated with less sexual pleasure caused by physical impairment. Satisfaction with partnership (p < .001, Beta = .22), satisfaction with sexual life (p < .001, Beta = .28), and conversation about fertility (p < .05, Beta = .26) were associated with better quality of life.

Conclusion
Even though long-term survivors seem to be generally satisfied with their partnership and sexual life, they may suffer from specific impairments. Our findings need to be verified in longitudinal studies.
Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study
Authors: Kim Bukyung , Lee Hak Sung , Kim Hye-Jin , Lee Hyolynn , Lee In-young , Ock Soyoung , Kwon Sukyoung , Kang Sang-Soo , Choi Youngsik 
Published: December 2022

AbstractThis study was performed to investigate the effects of bitter melon extract (BME) on glucose metabolism, insulin resistance, and various metabolic parameters of participants with prediabetes. A 12-week randomized placebo-controlled clinical study was conducted with prediabetic patients. A total of 76 participants were randomly assigned to initiate the study. In the final analysis, 33 and 32 subjects were included in the BME and placebo groups, respectively. Results showed that 75 g oral glucose tolerance test (OGTT) blood glucose level decreased in BME group after 12 weeks. The glucose level after 30 min of glucose ingestion decreased significantly. The glucagon level in the BME group after 12 weeks significantly decreased 120 min after 75 g OGTT. These results suggested that bitter melon exhibits glucose-lowering effects through suppression of glucagon levels in people with prediabetes.
Ultraviolet spectropolarimetry with polstar: interstellar medium science
Authors: Andersson B-G , Clayton G. C. , Doney K. D. , Panopoulou G. V. , Hoang T. , Magalhaes A. M. , Yan H. , Ignace R. , Scowen P. A. 
Published: December 2022

AbstractContinuum polarization over the UV-to-microwave range is due to dichroic extinction (or emission) by asymmetric, aligned dust grains. Scattering can also be an important source of polarization, especially at short wavelengths. Because of both grain alignment and scattering physics, the wavelength dependence of the polarization, generally, traces the size of the aligned grains. Similarly because of the differing wavelength dependencies of dichroic extinction and scattering polarization, the two can generally be reliably separated. Ultraviolet (UV) polarimetry therefore provides a unique probe of the smallest dust grains (diameter$< 0.09~\upmu \text{m}$
<
0.09

μm
), their mineralogy and interaction with the environment. However, the current observational status of interstellar UV polarization is very poor with less than 30 lines of sight probed. With the modern, quantitative and well-tested, theory of interstellar grain alignment now available, we have the opportunity to advance the understanding of the interstellar medium (ISM) by executing a systematic study of the UV polarization in the ISM of the Milky Way and near-by galaxies. The Polstar mission will provide the sensitivity and observing time needed to carry out such a program (probing hundreds of stars in the Milky Way and dozens of stars in the LMC/SMC), addressing questions of dust composition as a function of size and location, radiation- and magnetic-field characteristics as well as unveiling the carrier of the 2175 Å extinction feature. In addition, using high-resolution UV line spectroscopy Polstar will search for and probe the alignment of, and polarization from, aligned atoms and ions - so called “Ground State Alignment”, a potentially powerful new probe of magnetic fields in the diffuse ISM.
A comparison between the Felix™ electrophoretic system of sperm isolation and conventional density gradient centrifugation: a multicentre analysis
Authors: Shapouri Farnaz , Mahendran Tara , Govindarajan Mirudhubashini , Xie Philip , Kocur Olena , Palermo Gianpiero D. , Bakos Hassan W. , Ahlström Aisling , Caisander Gunilla , Xu Bo , Bai Shun , Lambourne Sarah , Aitken R. John 
Published: December 2022

AbstractPurposeDeveloping optimized techniques for the isolation of human spermatozoa possessing low levels of DNA damage is an important objective for the ART industry. The purpose of this study was to compare a novel electrophoretic system (Felix™) of sperm isolation with a conventional method involving density gradient centrifugation (DGC).MethodsFive international ART Centres in Australia, India, Sweden, the USA, and China have collaborated in order to compare the quality of the sperm populations isolated by Felix™ and DGC in terms of processing time, sperm concentration, motility, vitality, and DNA integrity as assessed by 3 methods: SCSA, Halo, and TUNEL.ResultsAcross all centers, 112 comparisons were performed. Although significant differences were noted between centers in terms of the quality of the semen samples subjected for analysis, overall, both methods were equally capable of isolating populations of spermatozoa exhibiting high levels of vitality and progressive motility. The absolute numbers of spermatozoa recovered were significantly (p < 0.001) lower with the Felix™ device although sperm quality was higher with 4/5 centers reporting a significant improvement in DNA integrity relative to DGC (p < 0.01–p < 0.001). In practical terms, the Felix™ device featured a standardized 6 min preparation time whereas clinical DGC protocols varied from center to center but generally took around 40 min to complete.ConclusionsThe Felix™ device is a positive technical development capable of isolating suspensions of highly motile spermatozoa exhibiting low levels of DNA damage in a fraction of the time taken by conventional procedures such as DGC.
The DIY IVF cycle—harnessing the power of deeptech to bring ART to the masses
Authors: Brayboy Lynae M. , Quaas Alexander M. 
Published: December 2022

Abstract
The emergence of telehealth including telemedicine, at-home testing, and mobile health applications has enabled patients to self-manage their reproductive care, especially during the COVID-19 pandemic. Reproduction is rapidly changing and embracing deeptech initiatives that can improve outcomes and facilitate personalized fertility solutions in the near future. This so-called DIY IVF informed by deeptech and moderated by femtech not only holds a tremendous amount of promise, but also challenges and possible pitfalls. This review discusses the current status of deeptech and femtech for IVF care in a post-Roe v. Wade environment.
The Dynamic Interplay of Anxious and Depressive Symptoms in a Sample of Undergraduate Students
Authors: Marian Stefan , Costantini Giulio , Macsinga Irina , Sava Florin Alin 
Published: December 2022

AbstractThe network perspective on psychopathology suggests that mental disorders can be regarded as networks of elements that influence each other. In this study, we used network analysis to explore the temporal interactions of anxiety and depression symptoms at the level of day-to-day experiences and find potential explanatory pathways for their comorbidity. We collected intensive longitudinal data from a sample of undergraduate students and fitted a Multilevel Vector Autoregressive model on GAD and MDD DSM-5 symptoms. “Sad mood” and “Concentration difficulties” were responsible for the most connections between anxiety and depression symptoms and were also among the most central symptoms. It is possible that anxio-depressive comorbidity can be explained by the presence of “Sad mood” and “Concentration difficulties” and targeting these two symptoms in therapy can lead to beneficial effects in comorbid cases.
Development and retrospective evaluation of a clinical decision support system for the efficient detection of drug-related problems by clinical pharmacists
Authors: Skalafouris Christian , Blanc Anne-Laure , Grosgurin Olivier , Marti Christophe , Samer Caroline , Lovis Christian , Bonnabry Pascal , Guignard Bertrand 
Published: December 2022

Abstract
Background
Clinical decision support systems (CDSS) can help identify drug-related problems (DRPs). However, the alert specificity remains variable. Defining more relevant alerts for detecting DRPs would improve CDSS.

Aim
Develop electronic queries that assist pharmacists in conducting medication reviews and an assessment of the performance of this model to detect DRPs.

Method
Electronic queries were set up in CDSS using “triggers” from electronic health records: drug prescriptions, laboratory values, medical problems, vital signs, demographics. They were based on a previous study where 315 patients admitted in internal medicine benefited from a multidisciplinary medication review (gold-standard) to highlight potential DRPs. Electronic queries were retrospectively tested to assess performance in detecting DRPs revealed with gold-standard. For each electronic query, sensitivity, specificity, positive and negative predictive value were computed.

Results
Of 909 DRPs, 700 (77.8%) were used to create 366 electronic queries. Electronic queries correctly detected 77.1% of DRPs, median sensitivity and specificity reached 100.0% (IQRs, 100.0%–100.0%) and 99.7% (IQRs, 97.0%–100.0%); median positive predictive value and negative predictive value reached 50.0% (IQRs, 12.5%–100.0%) and 100.0% (IQRs, 100.0%–100.0%). Performances varied according to “triggers” (p < 0.001, best performance in terms of predictive positive value when exclusively involving drug prescriptions).

Conclusion
Electronic queries based on electronic heath records had high sensitivity and negative predictive value and acceptable specificity and positive predictive value and may contribute to facilitate medication review. Implementing some of these electronic queries (the most effective and clinically relevant) in current practice will allow a better assessment of their impact on the efficiency of the clinical pharmacist.
The Persistence of the Gender Earnings Gap: Cohort Trends and the Role of Education in Twelve Countries
Authors: Bar-Haim Eyal , Chauvel Louis , Gornick Janet C. , Hartung Anne 
Published: December 2022

AbstractStudying twelve countries over 30 years, we examine whether women’s educational expansion has translated into a narrowing of the gender gap in earnings when including persons with zero earnings. As educational attainment is cohort-dependent, an Age-Period-Cohort analysis is most appropriate in our view. Using the micro data from the Luxembourg Income Study (LIS) Database, we show that while, in terms of attainment of tertiary education, women have caught up and often even outperform men, substantial gender differences in our earnings measure persist in all countries. Using the Blinder-Oaxaca decomposition method in an innovative age-period-cohort approach, we demonstrate that the role of education in explaining gender earnings differences has been limited and even decreased over cohorts. We also conclude that, when including persons not receiving earnings, earnings differences at levels far from gender equality will likely persist in the future, even if the “rise of women” in terms of education continues—as the share of women in higher education increases and the returns to education in particular for women declines.
Evolution of the academic emotions of academically low-achieving students in knowledge building
Authors: Yang Yuqin , Zhu Gaoxia , Chan Carol K. K. 
Published: December 2022

AbstractKnowledge Building is a pedagogical approach that emphasizes students’ collective responsibility to continuously improve their community knowledge. Advancing the frontiers of community knowledge is an exciting but challenging process, especially for low-achieving students, because it involves a continuous experience of cognitive disequilibrium and equilibrium. This knowledge generation process triggers various emotions (e.g., curiosity, surprise, and confusion) that may promote or hinder Knowledge Building. This study investigated the types and evolution of emotions experienced by academically low-achieving students in the Knowledge Building process supported by Knowledge Forum. The participants were 120 students from two Grade 9 classes and two Grade 11 classes in a Band 3 secondary school in Hong Kong. This school enrolls students performing at the 10th percentile on a pre-admission government examination at the end of elementary school. The participants built knowledge around Visual Arts. The emotions reflected in the digital Knowledge Forum notes and the evolution patterns of emotions in inquiry threads were both analyzed using content analysis and sequential pattern analysis. The participants demonstrated a high percentage of joy and relatively low percentages of frustration and boredom. Emotions were likely to maintain consistency (e.g., joy to joy) or transition between similar emotions (e.g., boredom to frustration) in the inquiry threads. By synthesizing the emotion transitions and subsequences manifested in the inquiry threads of different classes, we constructed a model of the evolution of emotions of academically low-achieving students during Knowledge Building. This model has implications for designing scaffolding or interventions to facilitate low-achieving students' learning and promote favorable emotions.
Use of multistate Bennett acceptance ratio method for free-energy calculations from enhanced sampling and free-energy perturbation
Authors: Matsunaga Yasuhiro , Kamiya Motoshi , Oshima Hiraku , Jung Jaewoon , Ito Shingo , Sugita Yuji 
Published: December 2022

AbstractMultistate Bennett acceptance ratio (MBAR) works as a method to analyze molecular dynamics (MD) simulation data after the simulations have been finished. It is widely used to estimate free-energy changes between different states and averaged properties at the states of interest. MBAR allows us to treat a wide range of states from those at different temperature/pressure to those with different model parameters. Due to the broad applicability, the MBAR equations are rather difficult to apply for free-energy calculations using different types of MD simulations including enhanced conformational sampling methods and free-energy perturbation. In this review, we first summarize the basic theory of the MBAR equations and categorize the representative usages into the following four: (i) perturbation, (ii) scaling, (iii) accumulation, and (iv) full potential energy. For each, we explain how to prepare input data using MD simulation trajectories for solving the MBAR equations. MBAR is also useful to estimate reliable free-energy differences using MD trajectories based on a semi-empirical quantum mechanics/molecular mechanics (QM/MM) model and ab initio QM/MM energy calculations on the MD snapshots. We also explain how to use the MBAR software in the GENESIS package, which we call mbar_analysis, for the four representative cases. The proposed estimations of free-energy changes and thermodynamic averages are effective and useful for various biomolecular systems.
Limited enzymatic hydrolysis of green coffee protein as a technique for preparing new functional food components
Authors: Ali Mostafa , Rawel Harshadrai , Hellwig Michael 
Published: December 2022

AbstractValorisation of side-streams in food production has become an important booster for increased sustainability in food production. The objective of this work was to study and improve the functional properties of green coffee (GC) protein. Extraction of defatted GC meal by using PVPP slightly increased protein yield and significantly decreased the amount of covalently and non-covalently bound CQA, therefore decreasing the antioxidant activity of the meal. Peptic hydrolysis at pH 1.5 led to a significantly higher degree of hydrolysis (DH) than at pH 3. Sodium dodecylsulfate polyacrylamide gel electrophoresis (SDS-PAGE) showed that the molecular weights of peptides of GC protein hydrolysates were in the range of 11–60 kDa, while peptides were in the range of 500–5000 Da using matrix-assisted laser desorption/ionization-time of flight mass spectroscopy (MALDI-TOF MS). Additionally, the enzymatic hydrolysis significantly improved the antioxidant activity of the GC protein. Finally, the results suggest that enzymatic hydrolysis with pepsin is an effective technique to provide bioactive compounds. The works presented in our manuscript may help in further exploiting the potential use of green coffee beans for food, cosmetic or pharmaceutical industry.
The effects of gender stereotype-based interfaces on users’ flow experience and performance
Authors: Oliveira Wilk , Hamari Juho , Ferreira William , Toda Armando M. , Palomino Paula T. , Vassileva Julita , Isotani Seiji 
Published: December 2022

AbstractDespite recent advances in the personalization of education, it is still unknown how different kinds of personalization affect students’ experiences. To advance this literature, in this article, we present an experimental study with 307 participants investigating the effects of gender stereotype-based interfaces (in terms of colors and avatars stereotypes) on users’ flow experience (i.e., challenge–skill balance, merging of action and awareness, clear goals, feedback, concentration, control, loss of self-consciousness, and autotelic experience), and performance in a gamified educational system. The main results indicate that gender stereotype-based interfaces affect users’ action–awareness merging, however, do not affect users’ performance and overall flow experience. We contribute with the basis for new studies and challenge thorough future research attempts.