bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERAN DISIPLIN KERJA DALAM MEMEDIASI PENGARUH PENGAWASAN DAN MOTIVASI KERJA TERHADAP KINERJA PEGAWAI LEMBAGA PEMBINAAN KHUSUS ANAK KELAS II KENDARI
Authors: La Mane Irwan , Syaifuddin Dedy Takdir , Nur Nofal , Bua Hasanuddin , Ansir Ansir , Saleh Salma 
Published: April 2022

This study aims to analyze the effect of supervision, work motivation and work discipline on employee performance. To find out and analyze the effect of supervision and work motivation on work discipline, and see the mediating role of work discipline. This research was conducted at the Institute for Special Child Development Institution Class II Kendari. The population in this study amounted to 46 staff employees, sampling using census techniques with a total sample of 46 people. Research data were collected using a questionnaire and analyzed using Partial Least Square (PLS) analysis. The results of this study indicate that the higher level of supervision conducted will be able to improve work discipline and employee performance. Likewise, the higher work motivation of employees will lead to increased work discipline and employee performance. Work discipline plays a role in mediating the effect of supervision and work motivation on employee performance.This study aims to analyze the effect of supervision, work motivation and work discipline on employee performance. To find out and analyze the effect of supervision and work motivation on work discipline, and see the mediating role of work discipline. This research was conducted at the Institute for Special Child Development Institution Class II Kendari. The population in this study amounted to 46 staff employees, sampling using census techniques with a total sample of 46 people. Research data were collected using a questionnaire and analyzed using Partial Least Square (PLS) analysis.The results of this study indicate that the higher level of supervision conducted will be able to improve work discipline and employee performance. Likewise, the higher work motivation of employees will lead to increased work discipline and employee performance. Work discipline plays a role in mediating the effect of supervision and work motivation on employee performance.
PENGARUH	KUALITAS JASA TERHADAP KEPUASAN PASIEN YANG DIMEDIASI OLEH CITRA RUMAH SAKIT (STUDI PADA PASIEN RAWAT INAP DI RUMAH SAKIT TIARA SENTOSA KENDARI)
Authors: Sabdar La Ode Man , Bua Hasanuddin , Yusuf Hayat , Syaifuddin Dedy Takdir , Sinarwaty Sinarwaty , Yusuf Abd. Razak 
Published: April 2022

This study aims to: 1) examine the influence of service quality on hospital image, 2) examine the effect of service quality on patient satisfaction, 3) examine the influence of hospital image on patient satisfaction, 4) examine the effect of service quality on patient satisfaction mediated by hospital image. The type of this research is explanatory research, then seen from the approach of research strategy or data collection process, this research uses survey method. The population in this study was all patients treated at Tiara Sentosa Kendari Hospital. For sampling techniques researchers use non random or non probability selection in the form of purposive sampling. A total of 135 samples were obtained using the formula Hair et al (2010). Data is collected by interview methods and questionnaires. The analysis tool used is Partial Least Square (PLS). The results showed that both directly and indirectly, the quality of services has a positive and significant effect on patient satisfaction at Tiara Sentosa Kendari Hospital.
Investigating the Adipogenic Effects of Different Tissue-Derived Decellularized Matrices
Authors: Tang Weiya , Qi Jun , Wang Qian , Qu Yaping , Fu Su , Luan Jie 
Published: April 2022

Objective: Decellularized adipose-derived matrix (DAM) can promote adipogenic differentiation and adipose tissue remodeling, but the biological impact of tissue origin on DAM remains unknown. The present study aimed to investigate the effects of tissue origins on the adipogenic capacity of the decellularized matrix by comparing the cellular and tissue responses of DAM versus acellular dermal matrix (ADM).Methods: The in vitro response of adipose-derived stem/stromal cells (ADSCs) to DAM and ADM was characterized by proliferation and differentiation. The in vivo remodeling response was evaluated in the subcutaneous injection model of immunocompromised mice, using histology, protein expression, and transcriptome analysis.Results: Both DAM and ADM exhibited excellent decellularization effects and cytocompatibility. In the absence of exogenous stimuli, DAM could induce adipogenic differentiation of ADSCs compared with ADM. In the animal model, the levels of PDGF, VEGF, and ACRP30 were higher in the DAM groups than in the ADM group, and more neovascularization and extensive adipose tissue remodeling were observed. The mRNA-seq analysis indicated that the DAM implant regulated tissue remodeling by modulating Lat1/2 expression along with Hippo Signaling pathway in the early stage.Conclusion: Tissue origin can influence the biological response of the decellularized matrix. DAM can retain favorable tissue-specific characteristics after the decellularization process and have unique adipogenic effects in vitro and vivo, which can be fully utilized for soft tissue repair and regeneration.
SS31 Ameliorates Oxidative Stress via the Restoration of Autophagic Flux to Protect Aged Mice From Hind Limb Ischemia
Authors: Yang Qiaoyun , Li Chunqiu , Chen Qingwei 
Published: April 2022

BackgroundOxidative stress and impaired autophagic flux play important roles in the development of peripheral artery disease (PAD). SS31 is considered an important antioxidant peptide and autophagy regulator. We aimed to investigate the role of SS31 in PAD myopathy and its possible mechanism both in vivo and in vitro.MethodsA hind limb ischemia (HLI) model was established with old C57BL/6 (14-month-old) mice. Mice in the SS31 group were intraperitoneally injected with SS31 (3 mg/kg) for 4 weeks. We examined skeletal muscle function and histomorphology, autophagy-related protein levels and reactive oxygen species (ROS) content. For the in vitro experiments, after C2C12 myotubes were treated with CoCl2, SS31, and chloroquine (CQ) or rapamycin (RAPA), we measured ROS content, autophagy-related protein levels and antioxidant enzyme expression.ResultsSS31 treatment effectively enhanced the recovery of skeletal muscle function, alleviated skeletal muscle injury and suppressed mitochondrial ROS production in ischemic limbs. SS31 reduced apoptosis and oxidative stress, and SS31 restored impaired autophagic flux by inhibiting the AKT-mTOR pathway. In vitro studies showed that SS31 restored autophagic flux and improved oxidative stress in C2C12 cells. Moreover, phosphorylated AKT (p-AKT) and phosphorylated mTOR (p-mTOR) levels were reduced.ConclusionThese experiments indicated that SS31 can inhibit oxidative stress by restoring autophagic flux to reverse hypoxia-induced injury in vivo and in vitro.
Case Report: A First Case of Spontaneous Coronary Artery Dissection Potentially Associated With Scuba Diving
Authors: Mahendiran Thabo , Desgraz Benoît , Antiochos Panagiotis , Rubimbura Vladimir 
Published: April 2022

BackgroundScuba diving has rarely been associated with spontaneous arterial dissection. However, all documented cases have involved the cervicocranial arteries.Case summaryWe report the first case of spontaneous coronary artery dissection (SCAD) potentially associated with scuba diving in a 65-year-old female with no medical history or known cardiovascular risk factors. She presented with sudden-onset chest pain during her descent whilst scuba diving on holiday. An initial ECG revealed transient abnormalities, but due to normal initial blood tests, a reassuring echocardiogram, and the resolution of her symptoms, she was discharged from hospital without a clear diagnosis. During her subsequent presentation to our hospital 1 week later, electrocardiographic evidence of an inferior myocardial infarction (MI) was noted, with an echocardiogram revealing regional wall motion abnormalities of the left ventricular inferior wall. Coronary angiography revealed the presence of a SCAD of the posterior left ventricular artery, with cardiac magnetic resonance imaging confirming the presence of an inferior MI. As recommended in the majority of cases of SCAD, this case was managed conservatively with a favorable clinical course.ConclusionThis is the first reported case of SCAD potentially associated with scuba diving. It highlights the importance of considering SCAD in patients presenting with sudden-onset chest pain during physical activity, especially in female patients (including older patients) with no cardiovascular risk factors. Furthermore, it serves as a reminder that symptoms during scuba diving are not always related to decompression illness.
Long-Term Outcomes After Implantation of Magnesium-Based Bioresorbable Scaffolds—Insights From an All-Comer Registry
Authors: Bossard Matthias , Madanchi Mehdi , Avdijaj Dardan , Attinger-Toller Adrian , Cioffi Giacomo Maria , Seiler Thomas , Tersalvi Gregorio , Kobza Richard , Schüpfer Guido , Cuculi Florim 
Published: April 2022

BackgroundThe magnesium-based sirolimus-eluting bioresorbable scaffold (Mg-BRS) Magmaris™ showed promising clinical outcomes, including low rates of both the target lesion failure (TLF) and scaffold thrombosis (ScT), in selected study patients. However, insights regarding long-term outcomes (&gt;2 years) in all-comer populations remain scarce.MethodsWe analyzed data from a single-center registry, including patients with acute coronary syndrome (ACS) and chronic coronary syndrome (CCS), who had undergone percutaneous coronary intervention (PCI) using the Mg-BRS. The primary outcome comprised the device-oriented composite endpoint (DoCE) representing a hierarchical composite of cardiac death, ScT, target vessel myocardial infarction (TV-MI), and clinically driven target lesion revascularization (TLR) up to 5 years.ResultsIn total, 84 patients [mean age 62 ± 11 years and 63 (75%) men] were treated with the Mg-BRS devices between June 2016 and March 2017. Overall, 101 lesions had successfully been treated with the Mg-BRS devices using 1.2 ± 0.4 devices per lesion. Pre- and postdilatation using dedicated devices had been performed in 101 (100%) and 98 (97%) of all the cases, respectively. After a median follow-up time of 62 (61–64) months, 14 (18%) patients had experienced DoCEs, whereas ScT was encountered in 4 (4.9%) patients [early ScTs (&lt;30 days) in three cases and two fatal cases]. In 4 (29%) of DoCE cases, optical coherence tomography confirmed the Mg-BRS collapse and uncontrolled dismantling.ConclusionIn contradiction to earlier studies, we encountered a relatively high rate of DoCEs in an all-comer cohort treated with the Mg-BRS. We even observed scaffold collapse and uncontrolled dismantling. This implicates that this metal-based BRS requires further investigation and may only be used in highly selected cases.
Higher Mortality Associated With New-Onset Atrial Fibrillation in Cancer Patients: A Systematic Review and Meta-Analysis
Authors: Murtaza Minha , Baig Mirza Mehmood Ali , Ahmed Jawad , Serbanoiu Liviu Ionut , Busnatu Stefan Sebastian 
Published: April 2022

AimThis research was conducted to evaluate the mortality outcome of cancer patients with new-onset atrial fibrillation. We also aimed to assess if there was any confounding relation between the mortality of these patients and surgical intervention.Materials and MethodsA systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to 7 February 2022. All statistical analyses were conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. Only those studies that involved cancer patients without pre-existing atrial fibrillation were selected, and mortality rate was compared between the patients who developed atrial fibrillation and those who did not. A random-effect model was used when heterogeneity was seen to pool the studies, and the result was reported in the odds ratio (OR) and the corresponding 95% confidence interval (CI).ResultsEighteen studies were selected for meta-analysis. Statistical analysis showed that the cancer patients who subsequently developed atrial fibrillation had a significantly higher mortality rate as compared to those who did not (OR = 1.90 [1.65, 2.19]; p &lt; 0.00001; I2 = 100%). We also separately analyzed the mortality risk in the surgery group and the non-surgery group. Statistical analysis showed that there was significantly higher mortality rate associated with new-onset atrial fibrillation in cancer patients in the surgery group (OR= 3.68 [2.29, 5.94]; p &lt; 0.00001; I2 = 61%) as well as in the non-surgery group (OR = 1.64 [1.39, 1.93]; p &lt; 0.00001; I2 = 100%).ConclusionCancer patients, who subsequently developed atrial fibrillation, had a higher mortality rate as compared to those cancer patients who did not develop atrial fibrillation. A higher mortality rate was seen in both surgical and non-surgical subgroups. This implies that extra care and specific measures must be taken in the management of cancer patients with new-onset atrial fibrillation.
Experimental Investigation of Shale Rock Properties Altering In-Situ Gas Density and Storage
Authors: Lou Xuanqing , Chakraborty Nirjhor , Karpyn Zuleima 
Published: April 2022

Shale gas reservoir has become a crucial resource for the past decade to sustain growing energy needs while reducing the carbon intensity of energy systems relative to other fossil fuels. However, these reservoirs are geologically complex in their chemical composition and dominance of nano-scale pores, resulting in limited predictability of their effective storage capacity. To predict gas storage and estimate volumetric gas-in-place, in-situ gas properties need to be defined. However, only a few direct experimental measurements on in-situ gas properties are available in the literature, and the interactions between gas and the surrounding surface area of the medium remain poorly understood. In this study, gas invasion experiments were conducted in conjunction with 3D X-ray micro-CT imaging on three different shales, i.e., Bakken, Haynesville and Marcellus. Results show evidence of increased storage capacity in all cases, with different degrees of gas densification across the three shale specimens. The average of measured in-situ xenon density within the Bakken, Haynesville and Marcellus shale samples were found to be 171.53 kg/m3, 326.05 kg/m3 and 947 kg/m3, respectively. These measured densities are higher than their corresponding theoretical free gas density, though lower than the xenon density at boiling point, indicating that current practices of estimating adsorbed gas and gas in place, using boiling point liquid density, may be overestimated. The xenon densification factor in the Marcellus sample was found to be 7.4, indicating the most significant degree of localized densification. This densification factor drops to 2.6, and to 1.4, in the Haynesville and the Bakken sample, respectively. Characterization of shale composition and pore structure are presented, in order to assess the shale properties controlling in-situ gas density and storage capacity. Results indicate that the observed degree of gas densification in shales can be attributed to surface area and pore size. The findings in this work provide valuable reference for simulation to much more accurately predict gas storage in shales. More importantly, the contribution of this work lay a foundation to evaluate excess storage capacity of various gases in ranging tight formations.
Maternal Urinary Cotinine Concentrations During Pregnancy Predict Infant BMI Trajectory After Birth: Analysis of 89617 Mother-Infant Pairs in the Japan Environment and Children’s Study
Authors: Hirai Hiroyuki , Okamoto Shiki , Masuzaki Hiroaki , Murata Tsuyoshi , Ogata Yuka , Sato Akiko , Horiuchi Sayaka , Shinohara Ryoji , Shinoki Kosei , Nishigori Hidekazu , Fujimori Keiya , Hosoya Mitsuaki , Yasumura Seiji , Hashimoto Koichi , Yamagata Zentaro , Shimabukuro Michio ,   the JECS Group
Published: April 2022

BackgroundClinical or epidemiological conclusions remain undecided on the direct effects of active and second-hand smoking during pregnancy on childhood obesity. Urinary cotinine (UC) concentration, an accurate and quantitative marker for smoking, may elucidate the dose-dependent relationship between smoking during pregnancy and childhood obesity. To analyze the relationship between UC concentration and smoking questionnaire (SQ) classes for active and second-hand smoking in pregnant mothers and trajectory of infant Kaup index (body mass index: BMI).MethodsThis multicenter prospective cohort study was conducted using a list-wise complete set of 35829 among 89617 mother-infant singleton pairs, recruited between 2011 and 2014, in the Japan Environment and Children’s Study (JECS). Pairs were categorized according to UC levels (1 to 4 classes) or SQ (0 to 4 classes).ResultsMaternal BMI at delivery was the highest in UC class 4 (highest). Maternal and paternal education of ≥16 years and annual household income were lowest in UC class 4. Infant BMI was lower at birth, but trends in BMI and ΔBMI were higher from six to 36 months step-wise in the UC classes. The above tendency was observed in the list-wise complete dataset but was emphasized after multiple imputations and corrections of cofounders. UC concentration in five SQ classes largely fluctuated, and the relationship between SQ classes and trends in BMI and ΔBMI was not statistically significant.ConclusionInfants from high UC mothers had a low BMI at birth, increasing from six to 36 months of age. UC concentrations, but not smoking questionnaire classes, predict infant BMI trajectory, suggesting that active and second-hand smoking affect child obesity in a dose-dependent manner.
Chaotic Oscillation Control Model of Power System Under Electromechanical Power Disturbance
Authors: Hu Qiankun 
Published: April 2022

The influence of electromechanical power on the power system is controlled in order to stabilize the power system. The author establishes a fourth-order power system model with a power disturbance term based on the dissipative property; the possibility of the existence of a system chaotic attractor is analyzed using the Lyapunov exponent spectrum, bifurcation diagram, phase diagram, spectral entropy, etc., and the influence of the power disturbance term on the motion state of the system is studied. It can be seen that under the influence of the disturbance frequency, the system will exhibit sufficient dynamic behavior. The parameters of the power disturbance term are more sensitive to the influence of the system power angle, and when the disturbance amplitude reaches a certain value, the power angle will increase sharply, and eventually the system will become unstable. The experimental results show that when controller parameters c1=c2=60 are selected, thenτ = 0.01, η = 0.3, and ε = 0.001. Moreover, when two groups of different control objectives r = 1.2 + 0.1 sin(t) and r = 1.2 are chosen, it can be clearly seen that the power angle δ in the system is very unstable before the controller is connected and the fluctuations are large and irregular, whereas after the controller is added for 150 s, the power angle δ tends to become stable, the fluctuation range becomes small and regular, and the system has almost no chattering. In order to reflect the superiority of the author’s control method, under the same parameter conditions, the symbolic function θ(s)=sgn(s) is used as a switching function of the controller and the tracking control numerical simulation is carried out for the same control objectives r = 1.2 + 0.1 sin(t) and r = 1.2. The controller that adopts the relay characteristic function θ(s)=ss+|ε| as a switching function has a better control effect and the system is smooth and stable without chattering.
Comparing Decoupling and Driving Forces of CO2 Emissions in China and India
Authors: Jiao Ziheng , Xing Zhencheng , Zhang Guofeng , Ma Xiaolin , Wang Haikun 
Published: April 2022

As the two largest developing countries globally, China and India have become the top 1 and 3 carbon emitters, respectively. Quantitating their CO2 emissions in terms of the characteristics and driving factors is highly significant to mitigating global climate change. This study compiled the CO2 emission inventories from 1990 to 2017 in China and India. The Tapio model and index decomposition analysis were used to analyze the impact of socio-economic factors on CO2 emissions. We found that 1) CO2 emissions of China and India reached 9526 and 2242 Mt, respectively, in 2017. CO2 emissions increased during 1990–2017 with an average annual growth rate of 5% in both countries. 2) In China, the economic development has remained weakly decoupling from emissions since 2012, reaching a strong decoupling (-0.2) in 2017. In contrast, the contribution of India’s economy to emissions continued to increase, and the decoupling status showed continuous fluctuations. 3) Economic development and population explosion were the dominant factors driving CO2 emissions in the countries. The effect of energy intensity inhibited India’s emissions growth after 2008 with an impact degree lower than China. Overall, our findings on the impact of the economy and emission development may provide references for other developing countries at different stages to achieve low-carbon development.
Risk Factors and Prognosis of Early Recurrence in Stage I–II Endometrial Cancer: A Large-Scale, Multi-Center, and Retrospective Study
Authors: Dou Yingyu , Song Kun , Fu Yu , Shen Yuanming , Zhang Chuyao , Yao Shuzhong , Xu Congjian , Xia Min , Lou Ge , Liu Jihong , Lin Bei , Wang Jianliu , Zhao Weidong , Zhang Jieqing , Cheng Wenjun , Guo Hongyan , Guo Ruixia , Xue Fengxia , Wang Xipeng , Han Lili , Zhao Xia , Li Xiaomao , Zhang Ping , Zhao Jianguo , Ma Jiezhi , Li Wenting , Yang Xiaohang , Wang Zizhuo , Liu Jingbo , Fang Yong , Li Kezhen , Chen Gang , Sun Chaoyang , Cheng Xiaodong , Jiang Jie , Wang Beibei , Luo Danfeng , Kong Beihua ,   The Chinese Endometrial Carcinoma Consortium (CECC)
Published: April 2022

ObjectiveThe aim of the present study was to determine overall survival (OS) and risk factors associated with early recurrence in patients with FIGO I–II stage endometrial carcinoma (EC).MethodsClinical features were retrospectively extracted from the database of China Endometrial Cancer Consortium from January 2000 to December 2019. A total of 2,974 patients with Federation International of Gynecology and Obstetrics (FIGO) I–II stage endometrial cancer were included. Kaplan-Meier survival analysis was used to assess OS and disease-specific survival. Cox proportional hazard model and Fine-Gray model were used to determine the factors related to OS. Binary logistic regression model was used to determine independent predictors of early relapse patients.ResultsOf these 2,974 ECs, 189 patients were confirmed to have relapse. The 5-year OS was significantly different between the recurrence and non-recurrence patients (p &lt; 0.001). Three quarters of the relapse patients were reported in 36 months. The 5-year OS for early recurrence patients was shorter than late recurrence [relapse beyond 36 months, p &lt; 0.001]. The grade 3 [odds ratio (OR) = 1.55, 95%CI 1.17–2.05, p = 0.002], lymphatic vascular infiltration (LVSI; OR = 3.36; 95%CI 1.50–7.54, p = 0.003), and myometrial infiltration (OR = 2.07, 95%CI 1.17—3.65, p = 0.012) were independent risk factors of early relapse. The protective factor of that is progesterone receptor (PR)-positive (OR = 0.50, 95%CI 0.27–0.92, p = 0.02). Bilateral ovariectomy could reduce recurrence risk rate (OR = 0.26, 95%CI 0.14–0.51, p &lt; 0.001).ConclusionThe OS of early relapse EC is worse. Grade 3, LVSI, and myometrial infiltration are independent risk factors for early relapse EC. In addition, the protective factor is PR-positive for those people and bilateral salpingo-oophorectomy could reduce the risk of recurrence.