bluuebunny/crossref_metadata_2025_split huggingface dataset:
Landslide Investigations Using Direct Current Resistivity and Ground Penetrating Radar Methods: Case study Cikahuripan Vilage, Bandung
Authors: Widodo Widodo , Fatkhan Fatkhan , Parnadi Wahyudi W , Santoso Djoko , Alawiyah Susanti , Abdurahman Dadi , Laesanpura Agus 
Published: August 2022

Abstract
At present there are many natural hazards in Indonesia especially landslides. Therefore, investigating landslides become essential due to their impacts on greater risk of destructions and loss of life. The mitigation approach for investigating landslide is to determine potential slip zones of vulnerable area. As we know that landslides occur mostly in a certain region of Bandung, Indonesia. Hence, geophysical measurements were carried out to investigate the potential slip zone in the research area, Cikahuripan Village, Parongpong Subdistrict, Bandung. We conducted Ground Penetrating Radar (GPR) and Direct Current Resistivity (DCR) measurements along six profiles. The geophysical survey of GPR was conducted using a 100 MHz GPR shielded antenna frequency and was obtained of two long profiles, whilst DCR was conducted using dipole-dipole configuration with four long profiles. Based on the integration of all GPR and DCR data were processed yielding the quasi 3D resistivity cross-section. The research area shows three lithology layers which are sandy tuff, clay tuff and lava breccia with range of resistivity value of 19,5–74 Ωm, 5–19,5 Ωm and more than 74 Ωm, respectively. The reimaging geological cross-section corresponds to GPR and DCR models indicating a potential slip zone. This appears as clay lithology at the depth of 4–16 meters beneath the surface. GPR and DCR results show that models are mutually supportive and consistent with each other.
Association of prophylactic heparin therapy and outcomes in critically ill patients with sepsis-induced coagulopathy: A marginal structural Cox model cohort study
Authors: Huang Jia-jia , zou zhiye , Zhou Zhi-peng , Liu Yan , Yang Zhen-jia , Zhang Jingjing , Luan Ying-yi , Yao Yong-ming , Wu Ming 
Published: August 2022

Abstract
BackgroundSepsis-induced coagulopathy (SIC) is defined as infection-induced organ dysfunction and coagulopathy. Although anticoagulation with heparin has been widely used in practice, its effectiveness for treating SIC remains controversial. This study aimed to investigate whether prophylactic heparin administration would provide a survival advantage for patients with SIC.Methods Patients with SIC were identified from the Medical Information Mart for Intensive Care (MIMIC)-IV database. The primary endpoint was ICU mortality, and the secondary outcomes were 7-day, 14-day, and 28-day mortality as well as hospital mortality. A Cox proportional hazards model and propensity score matching (PSM) were used to account for baseline differences in the probability of using prophylactic heparin. The marginal structural Cox model (MSCM) was employed to adjust for both baseline and time-varying confounding factors. E-value analysis was used for unmeasured confounding.Results A total of 6498 septic patients with SIC were enrolled in the study, with 1284 in the heparin group and 5124 in the nonheparin group. There was no significant effect on ICU mortality in the overall population (prematched, hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.77-1.14, P=0.517, postmatched, HR 0.89, 95% CI 0.70-1.12, P=0.323). Interestingly, the MSCM identified a significant effect on ICU mortality in the overall population (HR 0.77, 95% CI 0.60-0.98, P=0.032). Stratification analysis with the MSCM showed that prophylactic heparin administration was associated with decreased ICU mortality only among patients with a SIC score of 4 (HR 0.63, 95% CI 0.45-0.89, P=0.009). Similar results were replicated with PSM only for patients with a SIC score of 4 (ICU mortality HR 0.68, 95% CI 0.49-0.95, P=0.025; 7-day mortality HR 0.59, 95% CI 0.36-0.98, P=0.040; 14-day mortality HR 0.66, 95% CI 0.44-0.98, P=0.040; Hospital mortality HR 0.77, 95% CI 0.58-1.03, P=0.074; 28-day mortality HR 0.77, 95% CI 0.54-1.10, P=0.147). E-value analysis indicated robustness to unmeasured confounding.Conclusions: Prophylactic heparin administration to patients with a SIC score of 4 appears to be associated with improved survival outcomes, including ICU mortality and 7-day and 14-day mortality, but not with improvement in hospital or 28-day mortality. These results need to be verified in prospective randomized controlled trials.
Human displacements from tropical cyclone Idai attributable to climate change
Authors: Mester Benedikt , Vogt Thomas , Bryant Seth , Otto Christian , Frieler Katja , Schewe Jacob 
Published: August 2022

Abstract
Extreme weather events often trigger massive population displacement. A compounding factor is that the frequency and intensity of such events is affected by anthropogenic climate change. However, the effect of historical climate change on displacement risk has so far not been quantified. Here, we show how displacement can be partially attributed to climate change, using the example of the 2019 tropical cyclone Idai in Mozambique. We estimate population exposure to flooding following Idai’s landfall, using a combination of storm surge modeling and flood depth estimation from remote sensing images, for factual (climate change) and counterfactual (no climate change) mean sea level and maximum wind speed conditions. We find that climate change has increased displacement risk from this event by approximately 3.1 to 3.5%, corresponding to 16,000 - 17,000 additional displaced persons. Besides highlighting the significant effects on humanitarian conditions already imparted by climate change, our study provides a blueprint for event-based displacement attribution.
The relationship between fun and the overall score of the MEEGA360 scale
Authors: Gini Federica , Bassanelli Simone 
Published: August 2022

Abstract
Fun plays a significant role in learning. Given its positive impact on education, the role of fun has often been investigated in the context of gamification and educational games. An important problem with the study of the role of fun in learning is the lack of consistency in the assessment. There are a few existing tools for the evaluation of fun alone, but it is rarely assessed along with the other features of usability and gaming experience on a single scale. With the intent to fill this gap, we present MEEGA360, a modified version of the MEEGA + scale. Strengths and limits of the MEEGA + scale will be described, along with our solutions, and a first application.
TNFRSF19 (TROY) as a plasma biomarker for diagnosing and monitoring intracranial aneurysms progression
Authors: Zhang Qian , Li Shifu , Tang Dong , Yan Langchao , Chen Zhou , Tao Wengui , Wang Ying , Huang Zheng , Chen Fenghua 
Published: August 2022

Abstract
Background
This study aimed to identify and validate potential blood biomarkers for intracranial aneurysms (IAs) using bioinformatics analysis.
Methods
GSE54083 dataset was downloaded, then differently expressed genes (DEGs) and weighted gene co-expression network analysis (WGCNA) were used to identify the consistently differential expression genes from non-IAs to rupture IAs. We then calculated the areas under the receiver operating characteristic curve (AUC) of each gene to evaluate their diagnostic capability. Moreover, the XCell algorithm was used to integrate the expression data to score the relative abundance of the vascular microenvironment. Lastly, qRT-PCR and ELISA assays were performed to validate potential biomarkers using our clinical samples.
Results
Six hub genes (TNFRSF19, FBXO38, SLC26A10, C11orf24, P2RX6, and RORC) were identified by AUCs greater than 0.9 in our bioinformatics analysis. From non-IAs to RIAs, the abundances of B cell types were increased while T cell types were decreased. NK T cells had the most cell abundance with a significant elevating trend. The qRT-PCR assay revealed that the expression trend of TNFRSF19, FBXO38, and RORC were consistent with the bioinformatics analysis. Eventually, the ELISA assay revealed that TNFRSF19 (TROY) was significantly elevated in patients with UIAs and RIAs. What’s more, the plasma TROY was positively correlated with CRP (r = 0.46), D-dimer (r = 0.39), and number of Neutrophil and white blood cells.
Conclusions
TNFRSF19 (TROY) might play a key role in the development of IAs and could be a novel blood-based biomarker for diagnosing IAs and monitoring the progression of IAs.
Zinc-modified phosphate-based glass micro-filler improves Candida albicans resistance of auto-polymerized acrylic resin without altering mechanical performance
Authors: Lee Myung-Jin , Kim Min-Ji , Mangal Utkarsh , Seo Ji-Yeong , Kwon Jae-Sung , Choi Sung-Hwan 
Published: August 2022

Abstract
Colonization of auto-polymerized acrylic resin by pathogenic Candida albicans is a common problem for denture users. In this study, zinc-modified phosphate-based glass was introduced into an auto-polymerized acrylic resin at concentrations of 3, 5, and 7 wt.%. The mechanical properties (flexural strength, elastic modulus, microhardness, and contact angle) and surface morphology of the resultant material were investigated, and the antimicrobial effect on C. albicans was examined. The mechanical properties slightly differed between the control and zinc-modified phosphate-based glass samples (p > 0.05); however, the number of C. albicans colony-forming units was significantly lower in the control (p < 0.05). Scanning electron microscopy revealed that C. albicans tended not to adhere to the material. Thus, the novel materials retained the advantageous mechanical properties of unaltered acrylic resins while simultaneously exhibiting a strong antimicrobial effect in vitro.
Ferritin Thresholds for Cardiac and Liver Hemosiderosis in β-thalassemia Patients: A Diagnostic Accuracy Study
Authors: Khezri Hadi Darvishi , Aliasgharian Aily , Naderisorki Mohammad , Kosaryan Mehrnoush , Ghazaiean Mobin , Fallah Hanie , Zahedi Mohammad , Karami Hossein 
Published: August 2022

Abstract
Background and Aim: Ferritin is frequently used to screen some dire consequences of iron overload in β-thalassemia patients. The study aimed to define the best cutoff point of ferritin to screen for cardiac and liver hemosiderosis in these cases.Methods: This was a registry-based study on β-thalassemia patients living throughout Mazandaran province, Iran (n=1959). In this diagnostic research, the index test was ferritin levels measured by a chemiluminescent immunoassay. As a reference test, T2*-weighted magnetic resonance imaging (T2*-weighted MRI) was applied to determine cardiac and liver hemosiderosis.Results: A cutoff point of 2027 ng/mL for ferritin showed a sensitivity of 50%, specificity 77.4%, PPV 42.1%, and NPV 82.5% for cardiac hemosiderosis (area under curve [AUC] 0.66, 95% CI 0.60–0.71, adjusted odds ratio [OR] 2.05, 95% CI 1.05–4.01). At an optimum cutoff point of 1090 ng/mL, sensitivity 66.7%, specificity 68%, PPV 82.9%, and NPV 46.8% for liver hemosiderosis were estimated (AUC 0.68, 95% CI 0.63–0.73, adjusted OR 3.93, 95% CI 2.02–7.64. Conclusion: The likelihood of cardiac hemosiderosis serum ferritin levels below 2027 ng/mL is 17.5%. Moreover, 82.9% of ꞵ-thalassemia patients with serum ferritin levels above 1090 ng/mL may suffer from liver hemosiderosis, regardless of the grades.
Analysis of the disease burden trend of malignant tumors of the female reproductive system in China from 2006 to 2020
Authors: Han Xiting , Wang Zhihong , Huang Dongmei , Deng Kehong , Wang Qian , Li Cancan , Zhu Jicun 
Published: August 2022

Abstract
Background
Chinese women account for 17.51% of the world's deaths because of malignant tumors of the reproductive system, which is a serious threat to women's life and health. We analyzed the changes in mortality and disease burden of cervical cancer, uterine cancer and ovarian cancer in China from 2006 to 2020 to provide a basis for formulating scientific prevention and control measures.
Methods
Annual death data for cervical cancer, uterine cancer and ovarian cancer were collected from the Chinese Cause of Death Surveillance. The crude mortality rate (CMR), age-standardized mortality rate (ASMR), annual percentage change (APC), and average APC (AAPC) were applied to analyze the trend of mortality. Loss of life expectancy (LLE) and years of life lost (YLL) were used to assess disease burden.
Results
From 2006 to 2020, a total ASMR and standardized YLL rates of malignant tumors of the reproductive system showed a relatively stable trend, leading to an average LLE of 0.18 years. The YLL rate was the highest in the 55–59 age group. The mortality rate and disease burden of the three types of cancer have changed from uterine cancer higher than cervical cancer and ovarian cancer in 2006 to cervical cancer higher than ovarian cancer and uterine cancer in 2020. The ASMR and standardized YLL rate of uterine cancer showed a downward trend, and AAPC was − 5.21% (-9.31%~-0.91%) and − 6.07% (-9.45%~-2.58%), respectively. The mortality rates of cervical cancer and ovarian cancer remain high.
Conclusion
The mortality and disease burden of malignant tumors of the female reproductive system in China are still at a high level. It is necessary to improve screening and prevention strategies as soon as possible, improve the techniques of diagnosis and treatment, and take adequate measures to protect women's life and health.
When Humans Were the Hunted: Bone-Tipped Arrowpoints in Prehispanic Sierras of Córdoba, Argentina
Authors: Medina Matías E. , Lallami Cristian , Pastor Sebastián 
Published: August 2022

Abstract
Projectile points are one of the most commonly preserved artefacts at archaeological sites worldwide, yet few studies have investigated how hunting and warfare intended use affected the design and morphological variation of this technology. This paper presents the techno-typological study carried out on seven bone projectile points closely associated to a burial assemblage excavated from El Alto 5 (~ 550 cal BP, Sierras of Córdoba, Argentina). The bone point assemblage provides a useful comparative model for interpreting the function of arrowpoints where this contextual data is unavailable, concerning primarily with the question of how archaeologists can accurately differentiate the arrow tips used for defense or attack from those used for hunting. Bone arrowpoints have barbed shoulders to resist removal from the wound and stems with serrated edges for a secure hafting. They required shafts few millimeter thicker than stone-tipped arrows for hafting, involving more kinetic energy to inflict severe injuries. The identification of a dark residue spattered over the blades opens the possibility that poison was applied to enhance the effectiveness of the shoot. The study is considered a starting point to build more accurate models to identify interpersonal violence during the Late Prehispanic Period of Sierras of Córdoba and neighboring regions, where most bone points occurred as domestic refuse and are not directly associated to human skeletal remains.
Neodymium-coated PECVD-designed silicon nanostructures: A comprehensive structural, morphological and spectroscopic investigation
Authors: Mefoued Amine , Mahmoudi Bedra , Benrekaa Nasser , Tiour Faiza , Menari Hamid , Naitbouda Abdelyamine , Manseri Amar , Brik Afaf , Mezghiche Salah , Debbab Moustafa 
Published: August 2022

Abstract
We report the optical, structural, and spectroscopic properties of thermally evaporated neodymium oxide (Nd2O3) thin films deposietd on a nanostructured silicon (Si-ns) matrix. The Si-ns thin films were grown by depositing silicon nitride (SiN) thin films using plasma enhanced chemical vapour deposition (PECVD). The gas ratio R=NH3/SiH4 was varied between 2.5 and 5 to obtain different stoichiometries and Si amounts in the SiN layers. Two sets of samples were analysed. The first set comprised samples prepared with gas ratios R=2.5, 3, 4, and 5 and annealed at 900°C for 15 min. For the second set, R was 2 and 4 for the samples annealed at 1100°C for 2 h. Both sets were thermally treated under nitrogen (N2) ambient. The nanocrystalline formation and layer thickness were assessed by atomic force microscopy (AFM) and scanning electron microscopy (SEM). UV-Vis absorption spectra revealed that the reflectance was lower for the Nd2O3-coated samples than for to the uncoated ones. This trend remained unchanged after the annealing. Optical band gap (Eg) was found to increase with increasing R (2.5, 3, and 4) with Eg = 1.28, 1.31 and 1.55 eV respectively for annealed samples. Refinement of nanostructures size was observed with higher Eg values. The presence of Nd, Si, oxygen (O) and phosphorus (P) was confirmed by energy dispersive spectroscopy (EDS) and secondary ion mass spectrometry (SIMS) data. Moreover, X-ray diffraction (XRD) and Raman spectroscopy were employed to determine and confirm amorphous silicon (a-Si), crystalline silicon (c-Si), Nd2O3 and SiN phases present in the Nd2O3-SiN bilayers. Crystallite sizes for Nd and Si found to be 40.7 and 6.82 nm respectively. After the annealing process, a Raman shift toward lower wavenumbers was observed for Si peak. XPS data revealed the formation of Nd2O3 thin films with a Nd-O bonding incorporating trivalent Nd ions (Nd3+).
Effect of peritoneal transport characteristics on prognosis of peritoneal dialysis patients: A retrospective cohort study
Authors: Xia Yangyang , Jiang Chunming , Liu Ying , Zhang Qingyan , Feng Yuan , Zhang Miao 
Published: August 2022

Abstract
Objective: We aimed to analyze the clinical characteristics of peritoneal dialysis (PD) patients with different baseline peritoneal transport characteristics and the effect of peritoneal transport characteristics on prognosis of PD patients.Methods: Patients who received PD for over 1 months in the Nanjing Drum Tower Hospital between January 2006 and December 2019 were included. They were divided into four groups according to the baseline dialysate/plasma creatinine (D/Pcr) value. The clinical characteristics, changes in peritoneal transport, and risk factors of death and technique failure were analyzed.Results: A total of 323 patients were enrolled, comprising 70 patients in the low transport group, 135 in the low average transport group, 101 in the high average transport group, and 17 in the high transport group. Multivariate logistic regression analysis suggested that male sex (OR = 1.529, 95%CI 1.003–2.330) and low albumin levels (OR = 0.910, 95%CI 0.869–0.952) were risk factors for baseline high peritoneal transport status. The survival rate in the high transport group was significantly lower than that of the low transport (χ2 = 3.953, P = 0.047), LA (χ2 = 4.355, P = 0.037) and high average transport groups (χ2 = 9.359, P = 0.002). There was no significant difference in technique failure rate among these four groups (χ2 = 0.107, P = 0.991). Multivariate Cox regression analysis suggested that age (HR = 1.053, 95%CI 1.026–1.082), Charlson's comorbidity index (HR = 1.630, 95%CI 1.307–2.032), and baseline high transport (HR = 3.280, 95%CI 1.109–9.699) were independent risk factors for patient death. Male sex (HR = 1.851, 95%CI 1.123–3.052), C-reactive protein levels (HR = 1.008, 95%CI 1.001–1.015), and peritonitis (HR = 2.312, 95%CI 1.430–3.739) were independent risk factors for technique failure.Conclusions: Initial high peritoneal transport status is an independent risk factor for patient death. Male sex and low albumin levels were determinants of baseline high peritoneal transport.
Hypocalcemia after parathyroidectomy in patients with a history of bariatric surgery
Authors: Lorenz F. Jeffrey , Goldenberg David 
Published: August 2022

Abstract
Purpose
A growing body of literature has suggested that a history of bariatric surgery increases the risk of hypocalcemia after subsequent thyroidectomy, however little is known about the risk after parathyroidectomy. The purpose of this study was to determine the incidence of hypocalcemia after parathyroidectomy in patients with prior bariatric surgery.
Methods
The TriNetX Research Network was queried using diagnosis and procedure codes to identify patients with a history of bariatric surgery who were subsequently diagnosed with primary hyperparathyroidism (PHP) and underwent parathyroidectomy between 2012 and 2022. The rate of short-term and permanent hypocalcemia after parathyroidectomy was compared between those with a history of bariatric surgery and matched controls who underwent parathyroidectomy alone.
Results
There were 34,114 patients diagnosed with PHP who underwent parathyroidectomy. Of this cohort, 1.5% (n = 520) had prior bariatric surgery. There were 91% females and 9% males in this subset of patients, and the average age was 59 years. Compared to matched controls who underwent parathyroidectomy alone, these patients had a significantly increased risk of short-term (RR, 95% CI, P) (21.5% vs. 12.3%; 1.8, 1.3–2.3, P < 0.001) and permanent (7.7% vs. <1.9%; 4.0, 2.0-7.9) hypocalcemia.
Conclusion
The current study is the first to indicate that patients with a history of bariatric surgery are at increased risk for short-term and permanent hypocalcemia after parathyroidectomy. Further research is required to determine optimal prevention and treatment strategies to decrease associated morbidity in this subset of patients.
Aerobiological investigation, meteorological impacts on pollen distribution and allergenicity of major pollen types in the atmosphere of Southeastern Nigeria
Authors: Alebiosu Olugbenga Shadrak , Adekanmbi Olusola Helen 
Published: August 2022

Abstract
Airborne palynomorphs are regarded as important organic granules causing human allergic reactions such as pollinosis and asthma. In the present study, monthly depositional amount of airborne pollen and fern spores, impact of the surrounding plants on pollen distribution and allergenicity of common airborne pollen types, were investigated at selected sampling stations in Ebonyi and Anambra States, Southeastern Nigeria. Bioaerosols were collected with Tauber-like pollen samplers and subjected to conventional palynological treatment processes, microscopy and photomicrography. Enumeration of plants within the immediate vegetation showed that local plants produced some atmospheric pollen types at the study locations. Among other meteorological parameters, only relative humidity was found to yield statistically significant and positive correlation with monthly total airborne pollen concentrations in Anambra State. A positive but not significant correlation was also found between total airborne pollen counts and relative humidity in Ebonyi State. Nephrolepis sp., Pteris sp. and a trilete fern produced spores, while diatoms were also recovered. Some common pollen types including those of Syzygium guineense (Willd.) DC. and Senna siamea (Lam.) Irwin et Barneby in Ebonyi State; Mariscus alternifolius Vahl. and Zea mays L. in Anambra State, were collected in order to quantify and extract their crude protein contents for Mus musculus sensitization to achieve serology (ELISA) and haematology (differential and total white blood cell counts). Statistical significance was tested and observed in the correlation between amounts of haematological and serological parameters yielded by each test group; variations between amounts of these parameters yielded by each test group and those of the control, as well as at differing periods of sensitization. In the Senna siamea test group of Mus musculus, histopathological morbid characteristics were observed, including areas of necrosis (presence of dead cells) in the bronchi of a mortality; areas of necrosis and congestion in the bronchi and lungs of another mortality, respectively, after second sensitization. The study confirmed all the selected pollen types as potential sources of allergy at the study areas and revealed a multiplex of interplay among triggers of pollen allergy at different intervals of administration in mice, establishing a model of immunological reactions to varied pollen antigens in humans.