bluuebunny/crossref_metadata_2025_split huggingface dataset:
PET With 11C-Methyl-l-Methionine as a Predictor of Consequential Outcomes at the Time of Discontinuing Temozolomide-Adjuvant Chemotherapy in Patients With Residual IDH-Mutant Lower-Grade Glioma
Authors: Beppu Takaaki , Iwaya Takeshi , Sato Yuichi , Nomura Jun-ichi , Terasaki Kazunori , Sasaki Toshiaki , Yamada Noriyuki , Fujiwara Shunrou , Sugai Tamotsu , Ogasawara Kuniaki 
Published: April 2022

Purpose
The aim of this study was to clarify whether PET with 11C-methyl-l-methionine (11C-met PET) can predict consequential outcomes at the time of discontinuing temozolomide (TMZ)-adjuvant chemotherapy in patients with residual isocitrate dehydrogenase gene (IDH)–mutant lower-grade glioma.

Patients and Methods
Among 30 patients showing residual lesions of IDH-mutant lower-grade glioma, we compared the tumor-to-normal brain tissue ratio of standardized uptake values (SUVT/N) from 11C-met PET at the time of discontinuing TMZ-adjuvant chemotherapy with putative predictive factors including age, Karnofsky Performance Scale, number of courses of adjuvant therapy, residual tumor size, and promotor methylation status of O6-methylguanine-DNA methyl-transferase gene (MGMT). For each factor, progression-free survival (PFS) was compared between groups divided by cutoff values, determined to predict tumor relapse using receiver operating characteristic curves for each factor. Univariate and multivariate analyses were conducted using log-rank testing and Cox regression analysis, respectively. In addition, PFS was compared between patients grouped by combined findings from multiple predictors identified from univariate and multivariate analyses.

Results
Univariate and multivariate analyses identified SUVT/N from 11C-met PET and MGMT methylation status as independent predictors of outcomes after TMZ discontinuation. When comparing 3 groups assigned by the combination of MGMT and SUVT/N findings, PFS differed significantly among groups.

Conclusions
The present study suggested that 11C-met PET at the time of discontinuing TMZ-adjuvant chemotherapy allows prediction of outcomes at least comparable to MGMT methylation status in patients with residual IDH-mutant lower-grade glioma. Further, 11C-met PET allows more precise prediction of outcomes by assessment in combination with MGMT findings.
Pseudemcibacter aquimaris gen. nov., sp. nov., isolated from an aquaculture farm
Authors: Wang Yu , Liu Yanbo , Li Yanyan , Sun Jia , Lai Qiliang , Zhu Hongmei , Zhou Hantao 
Published: April 2022

A rod-shaped, Gram-stain-negative, aerobic and non-motile bacterium, designated strain Y4T, was isolated from an aquaculture farm in Xiamen, PR China. Strain Y4T had 94.8, 93.3 and 91.8 % 16S rRNA gene sequence similarity to

Paremcibacter congregatus

ZYLT,

Emcibacter nanhaiensis

HTCJW17T and

Luteithermobacter gelatinilyticus

MEBiC09520T, respectively. The genomic DNA G+C content of strain Y4T was 42.7 mol%. The average amino acid identity and percentage of conserved proteins values between strain Y4T and type strains of the family

Emcibacteraceae

were 57.9–58.6 % and 44.5–47.6 %, respectively. Optimal growth was observed at 28 °C, at pH 7.0 and with 2 % (w/v) NaCl. The novel strain Y4T required Ca2+, K+ and Mg2+ ions in addition to NaCl for growth. The dominant fatty acids of strain Y4T were summed feature 3 (C16 : 1
ω7c/C16 : 1
ω6c), summed feature 8 (C18 : 1
ω7c/C18 : 1
ω6c) and C14 : 0 2-OH. The polar lipid profile contained phosphatidylethanolamine, phosphatidyglycerol, three unidentified aminolipids, four unidentified aminophospholipids and two unidentified lipids. Cells contained exclusively ubiquinone Q-10. On the basis of the polyphasic analysis, strain Y4T (=MCCC 1K06278T=KCTC 82926T) is considered to represent a novel species in a novel genus of the family

Emcibacteraceae

, for which the name Pseudemcibacter aquimaris gen. nov., sp. nov. is proposed.
Evaluating drivers of spatiotemporal individual condition of a bottom-associated marine fish
Authors: Lindmark Max , Anderson Sean C. , Gogina Mayya , Casini Michele 
Published: April 2022

AbstractAn organism’s body condition describes its mass given its length and is often positively associated with fitness. The condition of Atlantic cod (Gadus morhua) in the Baltic Sea has declined dramatically since the early 1990s, possibly due to increased competition, food limitation, and hypoxia. However, the effect of biotic and abiotic variables on body condition have not been evaluated at local scales, which is important given spatial heterogeneity. We evaluate changes in distribution, experienced environmental conditions, and individual-level condition of cod in relation to covariates at different spatial scales using geostatistical models with spatial and spatiotemporal random effects. Oxygen, sprat biomass, and temperature were positively related to condition, and depth negatively associated, but the effect sizes of these variables were small—spatial and spatiotemporal latent variables explained almost five times more variation than fixed effects. We also show that accounting for the heterogenous distribution of cod leads to both lover levels and steeper trends over time in experienced oxygen compared to those in the environment. Understanding the drivers of spatiotemporal variation in body condition is critical for predicting responses to environmental change and to effective fishery management; yet low explanatory power of covariates on individual condition constitutes a major challenge.
DNA metabarcoding reveals the threat of rapidly expanding barred owl populations to native wildlife in western North America
Authors: Kryshak Nicholas F. , Fountain Emily D. , Hofstadter Daniel F. , Dotters Brian P. , Roberts Kevin N. , Wood Connor M. , Kelly Kevin G. , Papraniku Isabel F. , Kulzer Paige J. , Wray Amy K. , Kramer H. Anu , Dumbacher John P. , Keane John J. , Shaklee Paula A. , Gutiérrez R.J. , Peery M. Zachariah 
Published: April 2022

AbstractInvasive predators can have detrimental impacts on native species and biological communities through direct consumptive effects and indirect effects on trophic interactions. As an invasive, apex predator achieving high densities, barred owls (Strix varia) may pose a substantial threat to native wildlife in western North American forests. Studies of the trophic ecology of barred owls in their invasive range, however, have involved morphological examinations of prey remains with limited taxonomic resolution. We conducted DNA metabarcoding using intestinal samples collected from barred owls at the leading edge of their range expansion in northeastern California. Using customized primers, we screened the intestinal contents of 124 barred owls and detected a broad diet of 78 unique prey types (48 vertebrates and 30 invertebrates), including many previously undetected prey types. Mammals were the most consumed vertebrate class (frequency of occurrence = 65%), followed by amphibians (32%), birds (22%), and reptiles (19%). Diets differed regionally but were similar among ages and sexes and exhibited limited variation in response to local environmental conditions. Our work highlights the generalist predatory strategy of invasive barred owls, indicates that they will not serve as ecological replacements for the congeneric spotted owls (S. occidentalis) they displace, and identifies numerous native species potentially threatened by their range expansion. Expanding currently limited barred owl removals could benefit native species and wildlife communities in western North America. More broadly, DNA metabarcoding provides a powerful tool for conducting detailed assessments of species consumed by invasive predators, potentially incentivizing conservation actions and improving outcomes.
Gut microbiota analysis of the western honeybee (Apis mellifera L.) infested with the mite Varroa destructor reveals altered bacterial and archaeal community
Authors: Kim Minji , Kim Woo Jae , Park Soo-Je 
Published: April 2022

AbstractThe western honeybee, Apis mellifera L., is a crop pollinator that makes royal jelly and other hive products. However, widespread concerns arise about opportunistic diseases (e.g., bacteria, fungi, or mites) or chemicals that have an effect on the health and number of colonies, as well as their activity. The relationships between the gut microbiota and its host are currently being researched extensively. The effects of Varroa destructor infection on the gut microbial community, in particular, have received little investigation. This work utilized amplicon sequencing of the bacterial and archaeal 16S rRNA genes to assess the bacterial and archaeal communities of adult bee groups (healthy and affected by Varroa designed in NG and VG, respectively) and larvae from Varroa destructor-infected hives. Our results suggest that the genus Bombella was substantially dominant in larvae, while the genera Gillamella, unidentified Lactobacillaceae, and Snodgrassella were significantly dominant in adult bees. NG and VG, on the other hand, did not differ statistically significantly. The PICRUSt study revealed a significant difference in the KEGG classifications of larvae and adult bee groups. A greater number of genes involved in cofactor and vitamin production were identified in larvae. Additionally, despite the complexity of the honeybee’s bacterial community, all groups exhibited a straightforward archaeal community structure. Surprisingly, methanogen was detected in low abundance in the microbiota of honeybees. In summary, larvae and adult bees infected with Varroa destructor exhibit altered gut microbiota composition and function.
BIN2 phosphorylates the Thr280 of CO to restrict its function in promotingArabidopsisflowering
Authors: Ju Lan , Dong Huixue , Yang Ruizhen , Jing Yexing , Zhang Yunwei , Liu Liangyu , Zhu Yingfang , Chen Kun-Ming , Sun Jiaqiang 
Published: April 2022

AbstractCONSTANS (CO) is a central regulator of floral initiation in response to photoperiod. In this study, we show that the GSK3 kinase BIN2 physically interacts with CO and the gain-of-function mutantbin2-1displays late flowering phenotype through down-regulation ofFTtranscription. Genetic analyses show that BIN2 genetically acts upstream of CO in regulating flowering time. Further, we illustrate that BIN2 phosphorylates the Thr280 residue of CO. Importantly, the BIN2 phosphorylation of Thr280 residue restricts the function of CO in promoting flowering. Moreover, we reveal that the N-terminal part of CO harboring the B-Box domain mediates the interaction of both CO-CO and BIN2-CO. We find that BIN2 inhibits the formation of CO dimer/oligomer. Taken together, this study reveals that BIN2 regulates flowering time through phosphorylating the Thr280 of CO and inhibiting the CO-CO interaction inArabidopsis.HighlightBIN2 regulates flowering time through phosphorylating the Thr280 of CO inArabidopsis.
The impact of government nonmarket policy on a firm's financial performance: a lesson from COVID-19 pandemic lockdown's policy
Authors: Brahmana Rayenda Khresna , Setiawan Doddy , Trinugroho Irwan 
Published: April 2022

PurposeThis paper examines the effect of lockdown on a firm's financial performance. The authors aim to fill in the debate over the corporate world's repercussions from governments' COVID-19 response. Therefore, it is imperative to understand what effect the lockdown policy has on firm financial performance.Design/methodology/approachThe study data are cross-sectional, covering a sample of 246 listed firms in Indonesia. The lockdown policy and period data were retrieved from the Indonesian Ministry of Health COVID-19 special task force website. The authors’ empirical model for performance specification is based on annual data, following a common performance function in economics and finance literature. In addition to controlling for the standard error and province effect, the authors also controlled the COVID-19 cases and the province effect.FindingsThe lockdown deteriorates the firm's profitability, but it is not up to making the firms at financial distress level. Simply put, lockdown erodes the profitability significantly, leading to declining performance; however, it does not mean the firms generate default.Research limitations/implicationsSeveral shortcomings in the authors’ empirical setup need to be tackled for future research. For example, the study findings may limit the short-run effect but not the long-run effect (5–10 years after the pandemic). The findings also do not give room to justify that lockdown should not be imposed due to its deteriorating effect on the corporate world. Therefore, the authors leave this as a scope for future research.Originality/valueThis research is among the pioneer papers evaluating the effect of the government policy for mitigating the repercussions of COVID-19, and it reveals how this policy affects corporations.
The dark side of innovation in local authorities: influential typologies and impacted modalities
Authors: El Kadiri Boutchich Driss , Gallouj Nizar 
Published: April 2022

Purpose
This study aims to highlight the negative effects of innovation with regard to innovation typologies and human, organizational, economic and societal variables in local authorities.

Design/methodology/approach
To achieve the above objective, radial basis function, based on Softmax activation function, and partitioning variable, is applied on a sample of Moroccan local authorities.

Findings
The findings show that the typologies of innovation that significantly impact the aforementioned variables are standard innovation/tailor-made innovation, social innovation/commercial innovation and incremental innovation/breakthrough innovation. They also reveal that the modalities considerably impacted by innovation are deviance in reaction, procedural injustice, increase of hidden costs and negative effect on ethics-culture.

Originality/value
To the best of the authors’ knowledge, this study is original in that it can contribute to the research in the field of innovation, as it deals with its negative effects in terms of typologies, which are rarely processed in innovation research. Additionally, to overcome these negative effects, this work uses neural networks that are very scarcely used in such studies on innovation.
HumOSCM for pandemic response
Authors: Wagner Stephan M. , Tabaklar Tunca , Seifert Lysann 
Published: April 2022

PurposeHumanitarian organizations have faced the unprecedented consequences of the coronavirus disease 2019 (COVID-19) pandemic. In this article, the authors therefore discuss how epidemics and pandemics, specifically Ebola and COVID-19, have affected humanitarian operations and supply chain management (HumOSCM), and how HumOSCM has contributed to preparedness for and response to epidemics and pandemics. The authors present lessons learned from responses to Ebola and COVID-19.Design/methodology/approachFor this study, the authors review the scholarly HumOSCM literature, use documentary evidence from practitioner literature and apply a theory synthesis approach to derive recommendations on how HumOSCM could strengthen future responses to epidemics and pandemics.FindingsThe conceptualizations highlight the importance of strengthening collaboration, capability and capacity for the response to epidemics and pandemics. Furthermore, the components that can enhance the degree of collaboration, and hence, response formation, are discussed.Research limitations/implicationsAs a non-empirical article, it suffers from the limitations of conceptual research. Hence, empirical testing of the proposed framework is recommended. The framework and propositions can serve as a basis for future studies.Practical implicationsThe conceptual framework can help humanitarian organizations and other actors in the humanitarian sector to better understand how to prepare for future responses to epidemics and pandemics, in particular by considering the components that enhance the degree of collaboration, as well as through capability development and capacity building.Originality/valueThis article begins a discussion of how HumOSCM should evolve to better respond to future epidemics and pandemics.
The interaction between FDI, host country characteristics and economic growth? A new panel evidence from BRICS
Authors: Joo Bashir Ahmad , Shawl Sana , Makina Daniel 
Published: April 2022

PurposeThis study aims to assess the impact of foreign direct investment (FDI) on growth in presence of host country characteristics, namely, economic stability, human capital, financial development and trade openness, in the fastest emerging Brazil, Russia, India, China, South Africa (BRICS) economies, considered to be significant FDI destinations.Design/methodology/approachThe panel data for the variables under study, collected from World Investment Reports published by World Bank, are analyzed using feasible generalized least squares method to examine the relationship between the dependent and explanatory variables over the period 1987–2018. The interaction effect has been studied to examine the growth impact of FDI in presence of host country characteristics.FindingsThe findings revealed that FDI does not exert a significant impact on the economic growth of BRICS individually but has a significant growth impact only in presence of host country characteristics. FDI on interacting with financial development, trade openness and human capital exerts a positive impact on the economic growth of BRICS economies, and on interacting with economic instability (inflation), FDI has a negative impact on growth.Practical implicationsThe study has implications for policy makers of BRICS countries who are suggested to work toward the development of financial markets, trade liberalization and human capital development to realize the positive growth impact of FDI.Originality/valueVery few studies have been conducted to examine the growth effect of FDI in BRICS economies, which are considered to be the fastest-growing economies and dominant players in the global investment landscape. Assessing the interaction of FDI with absorptive capacities/host country characteristics to study its growth impact in BRICS using long data and robust panel data methodology is an original contribution of this paper toward the existing body of knowledge.
Identifying and assessing talent potential for future needs of a company
Authors: Kabalina Veronika , Osipova Alexandra 
Published: April 2022

PurposeThis article investigates which definitions, indicators and instruments are used by the companies to identify and assess talented employee potential with successful performance on future pivotal positions.Design/methodology/approachEmpirical data were collected in 2020–2021 in 45 local and multinational companies in Russia with well-established talent management functions using in-depth interviews with human resource (HR) managers and consultants.FindingsThe study found a diversity of approaches to identifying and assessing talent potential with a predominantly contextual approach but so far with little focus on company’s strategic objectives. It was also found that companies assessed cultural (values) fit, social intelligence and impact, engagement and commitment as predictors of managerial and leadership potential of talented employees for future strategic jobs, in addition to characteristics of personal resources. The search for new complex and validated tools and methods of potential assessment under budget constraints show that companies have taken the path of experimentation.Practical implicationsThe results of this research can inform talent and human resource managers how to identify and assess potential of talented employees for future needs of their organizations.Originality/valueThe paper contributes to the existing research in three ways. First, it offers a classification of approaches to potential assessment and explores the underlying dimensions of high-potential talent for future needs of a company. Second, it provides an overview of the current state of potential assessment in the companies in a non-western context. Third, it points out the challenges HR professionals face in implementing potential assessment for identifying talents in a new situation of unprecedented changes and uncertain future.
Social entrepreneurs in service: motivations and types
Authors: Samuelsson Peter , Witell Lars 
Published: April 2022

Purpose
This study aims to describe social entrepreneurs' motivation during the social entrepreneurship process and identify different social entrepreneurs in terms of their social characteristics.

Design/methodology/approach
The descriptive research design uses a directed qualitative interpretative approach based on 17 cases of social entrepreneurs active in healthcare innovation hubs.

Findings
The study describes the social entrepreneurs in a service context. Based on their key motivational characteristics, the study identifies three types of social entrepreneur: discoverers, seekers, and rangers. The study finds that not all of the three types regulate high levels of motivation during the social entrepreneurship process.

Research limitations/implications
Depending on the type of social entrepreneur, the social entrepreneurship process requires different forms of support. In practice, the traditional R&D process deployed by innovation hubs is suitable for rangers; discoverers and seekers commonly regulate low levels of motivation when developing and introducing their social innovations to the market.

Originality/value
Most service research on social entrepreneurship focuses on the outcome; in contrast, this empirical study focuses on the individual entrepreneurs, their motivation and process. While previous research has treated motivation as an antecedent for engagement in the social mission of entrepreneurship, the present study investigates social entrepreneurs’ motivation in relation to the social entrepreneurship process, providing insights in the behavior of social entrepreneurs.
Preference for teamwork, personal interaction and communities of practice: does co-worker support matter?
Authors: Dutta Anjali , Rangnekar Santosh 
Published: April 2022

Purpose
Collaboration and preference for teamwork play a fundamental role in strengthening practical completion of team tasks. An organizational culture should facilitate learning systems where knowledge creation occurs through socialization. The purpose of this study is to develop a moderated mediation model, investigating the conditional indirect effect of co-worker support on the relationship between preference for teamwork and communities of practice.

Design/methodology/approach
Questionnaire survey was conducted via Google Forms to collect data from 210 employees working in the private and public sector in India. Hayes PROCESS macro models were used for analyzing the mediation of personal interaction and moderation of co-worker support.

Findings
This study showed evidence regarding the mediating role of personal interaction on the relationship between preference for teamwork and communities of practice. Co-worker support moderated the relationship between personal interaction and communities of practice. It also moderated the conditional indirect effect.

Practical implications
The results approve the substantial role of preference for teamwork in influencing personal interaction and communities of practice. The mediating role of personal interaction on preference for teamwork and communities of practice can lead to creation and sustenance of communities of practice. Furthermore, the moderating role of co-worker support as a conditional indirect effect shows that social support and exchange can lead to social learning.

Originality/value
Theoretical explanations and analytical approaches provide insights into the relationship between the preference for teamwork and communities of practice through a conditional indirect effect, a one of its kind of a study.