bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectory Curves for Purposes of Benchmarking and Predicting Clinical Outcomes: A Scoping Review
Authors: Kelter Brian M , Wolfe Audrey E , Kazis Lewis E , Ryan Colleen M , Acton Amy , Slavin Mary D , Schneider Jeffrey C 
Published: January 2022

AbstractTrajectory curves are valuable tools to benchmark patient health status and predict future outcomes. A longitudinal study is underway to examine social participation after burn injury using the Life Impact Burn Recovery Evaluation (LIBRE) Profile with the goal of developing trajectory curves for specific domains that focus on social reintegration. We conducted a scoping review to inform and understand trajectory curves applied in clinical settings to compare outcomes for an individual to a matched cohort of comparable patients or predicted expected outcomes over time. This scoping review utilized a PubMed search from January 2014 to August 2019 for the following terms: “trajectory curves” or “trajectory models” and “clinic” or “clinical.” Only articles that specifically referenced longitudinal and clinical research designs were included in the scoping review. Articles were assessed using standard scoping review methods and categorized based on clinical application of trajectory curves for either benchmarking or prediction. The initial literature review identified 141 manuscripts and 34 met initial inclusion criteria. The reviewed articles support the clinical use of trajectory curves. Findings provide insight into several key determinants involved with the successful development and implementation of trajectory curves in clinical settings. These findings will inform efforts to use the LIBRE Profile to model social participation recovery and assist in developing effective strategies using trajectory curves to promote social reintegration after burn injury.
Background of radio photons from primordial black holes
Authors: Mittal Shikhar , Kulkarni Girish 
Published: January 2022

ABSTRACT
We compute the isotropic radiation background due to Hawking emission from primordial black holes (PBHs), and examine if this background is a viable option in explaining the excess radiowave background observed by the Absolute Radiometer for Cosmology, Astrophysics and Diffuse Emission (ARCADE2) and Long Wavelength Array (LWA1) experiments at $\lesssim 1\, {\rm GHz}$. We find that even under the extreme assumption that all of the dark matter is in the form of PBHs, the radio brightness temperature induced by Hawking evaporation of PBHs is $\mathcal {O}(10^{-46})\,$K, highly subdominant compared to the cosmic microwave background. The main reason for this is that for PBHs in the mass range ∼1012–${10^{14}}\, {\rm kg}$, which can be constrained by Hawking emission, the spectrum peaks at 107 to ${10^{5}}\, {\rm eV}$. As the Hawking spectrum is power law suppressed towards lower energies, negligible flux of $\mu \mathrm{eV}$ photons is obtained. The peak of the Hawking spectrum shifts to lower energies for higher masses, but the number density is low and so is the specific intensity. Because Hawking emission from PBHs is thus unable to explain the observed excess radio background, we also consider the alternative possibility of radio emission from gas accretion on to supermassive PBHs. These PBHs can readily produce strong radio emission that could easily explain the ARCADE2/LWA1 excess.
An INTEGRAL/SPI view of reticulum II: particle dark matter and primordial black holes limits in the MeV range
Authors: Siegert Thomas , Boehm Celine , Calore Francesca , Diehl Roland , Krause Martin G H , Serpico Pasquale D , Vincent Aaron C 
Published: January 2022

ABSTRACT
Reticulum II (Ret II) is a satellite galaxy of the Milky Way (MW) and presents a prime target to investigate the nature of dark matter (DM) because of its high mass-to-light ratio. We evaluate a dedicated INTEGRAL observation campaign data set to obtain γ-ray fluxes from Ret II and compare those with expectations from DM. Ret II is not detected in the γ-ray band 25–8000 keV, and we derive a flux limit of ${\lesssim}10^{-8}\, \mathrm{erg\, cm^{-2}\, s^{-1}}$. The previously reported 511 keV line is not seen, and we find a flux limit of ${\lesssim}1.7 \times 10^{-4}\, \mathrm{ph\, cm^{-2}\, s^{-1}}$. We construct spectral models for primordial black hole (PBH) evaporation and annihilation/decay of particle DM, and subsequent annihilation of e+s produced in these processes. We exclude that the totality of DM in Ret II is made of a monochromatic distribution of PBHs of masses ${\lesssim}8 \times 10^{15}\, \mathrm{g}$. Our limits on the velocity-averaged DM annihilation cross section into e+e− are $\langle \sigma v \rangle \lesssim 5 \times 10^{-28} \left(m_{\rm DM} / \mathrm{MeV} \right)^{2.5}\, \mathrm{cm^3\, s^{-1}}$. We conclude that analysing isolated targets in the MeV γ-ray band can set strong bounds on DM properties without multi-year data sets of the entire MW, and encourage follow-up observations of Ret II and other dwarf galaxies.
Risk Factors Associated with Healthcare Utilization for Spine Pain
Authors: Higgins Diana M , Han Ling , Kerns Robert D , Driscoll Mary A , Heapy Alicia A , Skanderson Melissa , Lisi Anthony J , Mattocks Kristin M , Brandt Cynthia , Haskell Sally G 
Published: January 2022

Abstract

Objective
This study examined potential risk factors associated with healthcare utilization among patients with spine (i.e., neck and back) pain.

Methods
A two-stage sampling approach examined spine pain episodes of care among veterans with a yearly outpatient visit for six consecutive years. Descriptive and bivariate statistics, followed by logistic regression analyses, examined baseline characteristics of veterans with new episodes of care who either continued or discontinued spine pain care. A multivariable logistic regression model examined correlates associated with seeking continued spine pain care.

Results
Among 331,908 veterans without spine pain episodes of care during the 2-year baseline observation period, 16.5% (n = 54,852) had a new episode of care during the following 2-year observation period. Of those 54,852 veterans, 37,025 had an outpatient visit data during the final 2-year follow-up period, with 53.7% (n = 19,865) evidencing continued spine pain care. Those with continued care were more likely to be overweight or obese, non-smokers, Army veterans, have higher education, and had higher rates of diagnoses of all medical and mental health conditions examined at baseline. Among several important findings, women had 13% lower odds of continued care during the final 2-year observation period, OR 0.87 (0.81, 0.95).

Conclusions
A number of important demographics and clinical correlates were associated with increased likelihood of seeking new and continued episodes of care for spine pain; however, further examination of risk factors associated with healthcare utilization for spine pain is indicated.
Cognitive difficulties in people with systemic sclerosis: a qualitative study
Authors: Chen Yen T , Lescoat Alain , Devine Anita , Khanna Dinesh , Murphy Susan L 
Published: January 2022

AbstractObjectivesThis study used a qualitative approach to explore how people with SSc experience cognitive changes and how cognitive difficulties impact their functioning.MethodsFour 90-min focus groups of adults with SSc and self-reported changes in cognition were recruited from a SSc research registry and targeted social media. A focus group guide elicited information from participants via open-ended questions. Content analysis was conducted using grounded theory methodology.ResultsThere were 20 participants (mean age = 55.5 (11.4) years) comprising 16 (80%) females, 14 (70%) Caucasians, and 11 (55%) people with diffuse cutaneous SSc. Study themes included cognitive difficulties as part of daily life experience, impact of cognitive difficulties on daily life functioning, coping strategies and information seeking. Participants used different terms to describe their experience of cognitive difficulties, and most encountered deficits in short-term memory, language difficulties, decreased executive function, difficulties with concentration and focus, and slow processing speed. Participants expressed frustration with their cognitive difficulties and used coping strategies to lessen their impact. Participants were uncertain about the causes and wanted to understand factors contributing to cognitive difficulties as well as how to manage them.ConclusionParticipants with SSc reported cognitive difficulties that had a substantial negative impact on their lives. Improved understanding of cognitive changes could subsequently facilitate development of relevant therapeutic interventions or educational programmes for symptom self-management to reduce impact of cognitive difficulties in people with SSc.
The impact of depression on mothers’ neural processing of their adolescents’ affective behavior
Authors: Barendse Marjolein E A , Allen Nicholas B , Sheeber Lisa , Pfeifer Jennifer H 
Published: January 2022

Abstract
Depression affects neural processing of emotional stimuli and could, therefore, impact parent–child interactions. However, the neural processes with which mothers with depression process their adolescents’ affective interpersonal signals and how this relates to mothers’ parenting behavior are poorly understood. Mothers with and without depression (N = 64 and N = 51, respectively; Mage = 40 years) from low-income families completed an interaction task with their adolescents (Mage = 12.8 years), which was coded for both individuals’ aggressive, dysphoric, positive and neutral affective behavior. While undergoing fMRI, mothers viewed video clips from this task of affective behavior from their own and an unfamiliar adolescent. Relative to non-depressed mothers, those with depression showed more aggressive and less positive affective behavior during the interaction task and more activation in the bilateral insula, superior temporal gyrus and striatum but less in the lateral prefrontal cortex while viewing aggressive and neutral affect. Findings were comparable for own and unfamiliar adolescents’ affect. Heightened limbic, striatal and sensory responses were associated with more aggressive and dysphoric parenting behavior during the interactions, while reduced lateral prefrontal activation was associated with less positive parenting behavior. These results highlight the importance of depressed mothers’ affective information processing for understanding mothers’ behavior during interactions with their adolescents.
The Associations of Hearing Sensitivity and Different Cognitive Functions with Perception of Speech-in-Noise
Authors: Merten Natascha , Boenniger Meta M. , Herholz Sibylle C. , Breteler Monique M.B. 
Published: January 2022

Objectives:
Impaired speech-in-noise perception affects individuals’ daily lives and is a frequent symptom of age-related hearing loss, which is a common disabling condition and a health concern in aging populations. The relative impact of hearing sensitivity loss and different cognitive functions on speech-in-noise perception is not well understood. We aimed to assess to what extent hearing sensitivity and different cognitive functions were associated with sentence-in-noise performance across the adult lifespan.

Design:
This study is based on data of 2585 participants of the Rhineland Study, which is a German community-based cohort study of persons of age 30 years and older. We assessed speech-in-noise with a sentence-in-noise test (Göttinger Satztest), hearing sensitivity thresholds (air conduction pure-tone audiometry [PTA] average of 0.5, 1, 2, and 4 kHz), and the following cognitive domains: crystallized intelligence (German Mehrfachwahl-Wortschatz-Intelligenztest, MWT-B), executive functioning (Trail Making Test B, TMT), working memory (Digit Span forward, DS), and long-term memory (Verbal Learning and Memory Test delayed recall; VLMT). We examined the association between hearing sensitivity and cognitive functions with sentence-in-noise perception using a multivariable linear regression model adjusted for age, sex, and multiple potential confounders.

Results:
Better hearing sensitivity was associated with better speech-in-noise perception (0.25 signal noise ratio [SNR] dB HL decrease per 5 dB HL decrease in PTA; 95% confidence interval [CI]: 0.20 to 0.25; p < 0.001). Better cognitive performance was also associated with better speech-in-noise perception, but to a lesser extent. Crystallized intelligence (MWT-B) showed an effect size of –0.10 SNR dB HL decrease per SD (95% CI: –0.14 to –0.06; p < 0.001), executive functioning (TMT) of –0.08 SNR dB HL decrease per SD (95% CI: –0.13 to –0.03; p = 0.002), working memory (DS) of –0.04 SNR dB HL decrease per SD (95% CI: –0.08 to –0.003; p = 0.03), and long-term memory (VLMT) of –0.03 SNR dB HL decrease per SD (95% CI: –0.07 to 0.01; p = 0.12). The standardized effect of hearing sensitivity (ß = 0.34) on speech-in-noise perception was four to five times larger than the effects of crystallized intelligence (ß = –0.08) and executive functioning (ß = –0.06).

Conclusions:
Hearing sensitivity was the strongest determinant of sentence-in-noise perception in adults above the age of 30. We determined the relative effect of different cognitive functions on sentence-in-noise perception. Crystallized intelligence and executive functions showed stronger associations while working and long-term memory functions had much smaller independent effects. Our results contribute to the understanding of determinants of speech-in-noise perception in aging adults.
Is Having Hearing Loss Fundamentally Different? Multigroup Structural Equation Modeling of the Effect of Cognitive Functioning on Speech Identification
Authors: Marsja Erik , Stenbäck Victoria , Moradi Shahram , Danielsson Henrik , Rönnberg Jerker 
Published: January 2022

Objectives:
Previous research suggests that there is a robust relationship between cognitive functioning and speech-in-noise performance for older adults with age-related hearing loss. For normal-hearing adults, on the other hand, the research is not entirely clear. Therefore, the current study aimed to examine the relationship between cognitive functioning, aging, and speech-in-noise, in a group of older normal-hearing persons and older persons with hearing loss who wear hearing aids.

Design:
We analyzed data from 199 older normal-hearing individuals (mean age = 61.2) and 200 older individuals with hearing loss (mean age = 60.9) using multigroup structural equation modeling. Four cognitively related tasks were used to create a cognitive functioning construct: the reading span task, a visuospatial working memory task, the semantic word-pairs task, and Raven’s progressive matrices. Speech-in-noise, on the other hand, was measured using Hagerman sentences. The Hagerman sentences were presented via an experimental hearing aid to both normal hearing and hearing-impaired groups. Furthermore, the sentences were presented with one of the two background noise conditions: the Hagerman original speech-shaped noise or four-talker babble. Each noise condition was also presented with three different hearing processing settings: linear processing, fast compression, and noise reduction.

Results:
Cognitive functioning was significantly related to speech-in-noise identification. Moreover, aging had a significant effect on both speech-in-noise and cognitive functioning. With regression weights constrained to be equal for the two groups, the final model had the best fit to the data. Importantly, the results showed that the relationship between cognitive functioning and speech-in-noise was not different for the two groups. Furthermore, the same pattern was evident for aging: the effects of aging on cognitive functioning and aging on speech-in-noise were not different between groups.

Conclusion:
Our findings revealed similar cognitive functioning and aging effects on speech-in-noise performance in older normal-hearing and aided hearing-impaired listeners. In conclusion, the findings support the Ease of Language Understanding model as cognitive processes play a critical role in speech-in-noise independent from the hearing status of elderly individuals.
Evolving perceptions regarding receiving orthopaedic care during the Coronavirus 2019 (COVID-19) pandemic: a follow-up survey
Authors: Only Arthur J. , Reams Megan , Comadoll Shea , Cunningham Brian P. 
Published: January 2022

Background:
As the Coronavirus 2019 (COVID-19) pandemic evolves, it is critical to understand how patients’ feelings and perceptions have changed. The aim of this study was to understand current feelings and concerns about seeking and receiving orthopaedic care 9 mo into the global pandemic.

Methods:
Utilizing a survey developed to evaluate the attitudes and beliefs from healthcare respondents about receiving care during the COVID-19 pandemic, an updated and revised version, evaluating changes in perception of respondents 9 mo into the pandemic, was distributed to a group of panelists by email.

Results:
Out of 1200 individuals, 197 (16%) completed the survey. A majority of respondents reported high level of comfort in the immediate or near-term receiving care in an orthopaedic clinic, urgent care clinic specifically for orthopaedics, or in an emergency room. Six percent of respondents reported a delay in seeking orthopaedic care despite COVID-19 concerns that occurred between studies. Respondents reported their primary reason for delaying care was because of concerns for risk of COVID-19 exposure from other patients (83%). More than 75% of respondents stated they are “extremely” or “very” likely to get the COVID-19 vaccine when it becomes available to the public. Respondents had a generally negative outlook on pandemic efforts locally to globally.

Conclusions:
Despite dismal overall perceptions regarding the outlook of the pandemic; consumers are becoming increasingly comfortable obtaining orthopaedic care. The ability of healthcare providers and practices to adherence to safety protocols will remain essential to maintaining consumer trust and confidence.

Level of Evidence:
Level IV.
Brief Report: Rapid Clinical Recovery From Critical Coronavirus Disease 2019 With Respiratory Failure in a Pregnant Patient Treated With IV Vasoactive Intestinal Peptide
Authors: Youssef Jihad Georges , Bitar Mohammad Z. , Zahiruddin Faisal , Al-Saadi Mukhtar , Elshawwaf Mahmoud , Yau Simon , Goodarzi Ahmad , Javitt Jonathan C. 
Published: January 2022

BACKGROUND:
Aviptadil, a synthetic form of human vasoactive intestinal peptide, has entered clinical trials to treat critical coronavirus disease 2019 pneumonia with respiratory failure. Vasoactive intestinal peptide protects the lung against a broad array of injuries by binding to the vasoactive intestinal peptide receptor 1 receptor of alveolar type II cells, the cells that severe acute respiratory syndrome coronavirus 2 binds to. As the role of Aviptadil in treating pregnant patients with critical coronavirus disease 2019 pneumonia is unknown, the authors report successful treatment in such a patient who is ineligible for phase 3 trials of Aviptadil.

CASE SUMMARY:
Under an open-label Food and Drug Administration-approved Expanded Access Protocol NCT04453839, a 32-year-old female patient Gravida 6 Para 4 at 27-week gestation, body mass index 42.5 kg/m2, admitted to the ICU of a quaternary care hospital with critical coronavirus disease 2019 was treated in January 2021 and followed for 4 months post-ICU admission. Standard of care included remdesivir, methylprednisolone, enoxaparin, and inhaled epoprostenol. In addition, the patient received three successive 12-hour IV infusions of Aviptadil at 50/100/150 pmol/kg/hr escalating doses, per randomized clinical trial NCT04311697. Human subjects’ protection was overseen by the Institutional Review Board of the Houston Methodist Hospital. The patient was enrolled in the treatment and was given informed consent approved by the Food and Drug Administration and the Institutional Review Board. Data on the patient was incorporated based on her consent for de-identified data to be used in research given at the time of hospital admission in a manner approved by the Institutional Review Board (PRO00025607). Baseline inflammatory markers, arterial blood gases, radiologic imaging, oxygen requirements, Pao
2/Fio
2, continuous fetal monitoring at baseline, throughout the patient’s treatment with the investigational drug, and throughout the patient’s hospital course.

CONCLUSION:
The rapid clinical improvement seen in this patient treated with IV vasoactive intestinal peptide is consistent with the theory that vasoactive intestinal peptide protects the alveolar type II cell, ameliorates cytokine storm, and improves oxygenation in acute lung injury. This specific role of vasoactive intestinal peptide in the lung may be vital to combating the lethal effects of severe acute respiratory syndrome coronavirus 2 infection. In addition, the role of vasoactive intestinal peptide in the human maternal-fetal interface suggests that vasoactive intestinal peptide is a safe treatment of severe coronavirus disease 2019 respiratory failure during pregnancy.
Describing Nonfatal Intimate Partner Strangulation Presentation and Evaluation in a Community-Based Hospital: Partnerships Between the Emergency Department and In-House Advocates
Authors: Bergin Audrey , Blumenfeld Elizabeth , Anderson Jocelyn C. , Campbell Jacquelyn C. , Patch Michelle 
Published: January 2022

Objective:
To describe characteristics of strangulation, and associated medical care, documentation, and injuries of women after nonfatal intimate partner strangulation (NF-IPS) who present for care to a community-based emergency department (ED) with an associated intimate partner violence (IPV) advocacy program between 2008 and 2016.

Setting, Design, and Participants:
A retrospective review of 345 female ED patients' medical records who sought care at a community hospital ED following a physical assault including strangulation by an intimate partner was conducted. Demographics, characteristics related to reported signs and symptoms, injuries, and subsequent imaging, diagnoses, and discharge information were abstracted.

Results:
Commonly reported symptoms were neck pain (67.2%) and headache (45.8%), with fewer patients reporting more severe symptoms such as loss of consciousness (22.6%), dysphagia (25.0%), or dysphonia (26.7%). Rates of patients disclosing strangulation to the entire multidisciplinary team and dedicated neck imaging appeared to improve between 2008 and 2014. Among the 45 patients with noted head and neck findings, 2 patients were found to have an internal carotid artery dissection, 2 patients were found to have strokes, and 1 patient was found to have an intracranial hemorrhage.

Conclusions:
Survivors of NF-IPS may present to community-based hospitals, and existing imaging guidelines can support clinicians in identifying serious internal injury such as carotid artery dissection and stroke. Further research is needed to better discern symptoms previously attributed to psychological trauma from poststrangulation brain injury. This study contributes to the growing literature on NF-IPS with data specific to community-based ED visits.