bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Integrated Approach of Yoga Therapy (IAYT) Versus Usual Care in Management on Chronic Low Back Pain Patients: a Randomized Controlled Pilot Study
Authors: Poojari Spoorthi , Dhiman Deepanshu , Ghai Babita , Mathur Deepali , Metri Kashinath , Kataria Ketan , Anand Akshay 
Published: January 2022

Abstract
This is a controlled randomized trial which evaluated the clinical and molecular changes resulting from Integrated approach of yoga therapy (IAYT) as an adjunct regimen and compared it with usual care for the management of chronic low back pain patients.­­ We enrolled 29 adult patients with chronic low back pain (CLBP). Patients were randomly divided into two groups. Control group received the usual care of treatment as per institutional protocol. The yoga group received IAYT as an adjunct to usual care. Primary outcomes were pain Intensity assessed by verbal numerical rating scale (VNRS) and functional ability assessed by Modified Oswestry Disability Index (MODI). Secondary outcomes were pain catastrophizing, quality of life, fear of movement related to CLBP, type of pain, levels of ß-Endorphin and TNF α and Salivary CGRP. All parameters were measured at baseline, one month, and three months. Significant decrease in VNRS score at 1 and 3 months was observed in both the groups with yoga group showing a more significant reduction in pain over time than the control group (p=0.036). MODI improved significantly only in the yoga group at 1 and 3 months. Intergroup comparison revealed significantly better MODI over time in the yoga group (p< 0.001). DN4, PDQ, PCS, HADS (anxiety) and Euro QOL had a statistically significant improvement at 1 month and 3 months in the Yoga group compared to the Control group. The HADS (depression) had a statistically significant reduction scores in yoga group at 3 months compared to control group (p=0.012). There was a significant reduction in TNF- α values in the yoga group compared to baseline(p=0.004). IAYT therapy helped in addressing the psychological components of pain and improved quality of life patients with chronic low back pain compared to usual care.
Molecular Characteristics of Mycobacterium Tuberculosis Drug-Resistant Isolates from HIV- and HIV+ Tuberculosis Patients in Russia
Authors: Panova Anna E. , Vinokurov Anatoliy S. , Shemetova Anastasiya A. , Burmistrova Irina A. , Shulgina Marina V. , Samoilova Anastasiya G. , Vasilyeva Irina A. , Vakhrusheva Diana V. , Umpeleva Tatiana V. , Eremeeva Nataliya I. , Lavrenchuk Leonid S. , Golubeva Lyudmila A. , Danilova Tatiana I. , Vasilyeva Tatiana B. , Ugol’kova Vera A. , Sosova Nataliya V. , Lekhlyaider Marina V. , Gorshkova Irina A. , Romanova Tatiana A. 
Published: January 2022

Abstract
Background

High burden of drug-resistant (DR) tuberculosis (TB) is a significant threat to national TB control programs all over the world and in the Russian Federation. Different Mycobacteria tuberculosis (MTB) genotypes are hypothesized to have specific characteristics affecting TB control programs. For example, Beijing strains are supposed to have higher mutation rates compared to strains of other genotypes and subsequently higher capability to develop drug-resistance
Results

Clinical MTB isolates from HIV- and HIV+ patients from four regions of Russia were analyzed for genotypes and mutations conferring resistance to Isoniazid, Rifampicin, Ethambutol, aminoglycosides, and fluoroquinolones. Analysis of genotypes and polymorphism of genomic loci according to the HIV status of the patients – sources of MTB isolates were performed. Studied MTB isolates from HIV- TB patients belonged to 15 genotypes and from HIV+TB patients – to 6 genotypes. Beijing isolates dominated in HIV- (64,7%) and HIV+ (74,4%) groups. Other isolates were of LAM (including LAM1 and LAM9), Ural, and 4 minor groups of genotypes (including 5 subclones T). The spectrum of genotypes in the HIV- group was broader than in the HIV+ group. PR of B0/W148 Beijing was significantly lower than of other Beijing genotypes in susceptible and MDR-XDR isolates. Rates of isolates belonging to non-Beijing genotypes were higher than Beijing in susceptible isolates from HIV- patients.
Conclusions

Beijing genotype isolates prevailed in isolates of all drug susceptibility profiles both in isolates from HIV- and HIV+ patients, although B0/W148 Beijing genotype did not dominate in this study. Genome loci and mutations polymorphisms were more pronounced in isolates from HIV- patients, than from HIV+.
Identifying Factors Associated With Hypertension Using Structural Equation Modeling: Evidence from a Large Kurdish Cohort Study in Iran
Authors: Najafi Farid , Moradinazar Mehdi , Rezayan Shahab , Azarpazhooh Reza , jamshidi Parastoo 
Published: January 2022

Abstract
BackgroundIdentifying the risk factors leading to hypertension can help explain why some populations are at a greater risk for developing hypertension than others. The present study seeks to identify the causal paths among the risk factors of hypertension in 35- to 65-year-old participants in western Iran.MethodsThe secondary analysis was conducted using the data obtained in the recruitment stage of Ravansar Non-Communicable Disease (RaNCD) cohort. Each of the latent variables were confirmed by confirmatory factor analysis. Using Structural Equation Modeling (SEM), we assessed the direct and indirect effects of the risk factors associated with hypertension.ResultsSocioeconomic status (SES), physical activity, lipid profile, obesity, Diabetes and family history of hypertension had a diverse impact on the blood pressure, directly and (or) indirectly. When investigating the latent and observers risk factors and the interrelations between different risk factors, The standardized total effect (the sum of direct and indirect effects, βt) of SES, physical activity, lipid profile, obesity, on the blood pressure was( -0.09 vs -0.14), (-0.04 vs -0.04), (0.13 vs 0.13), (0.24 vs 0.15) in men and women respectively. Diabetes had a direct relationship with the blood pressure in women (0.03).ConclusionWith regard to control of high blood pressure, public health interventions must target obesity,SES, lifestyle and nutritional factors such as hyperlipidemia and hyperglycemia in Iranian population
The Association of Hematological Inflammatory Markers and Psychological Function Among in COVID-19 Patients: a Cross Sectional Study
Authors: Khorasanchi Zahra , Mayvan Mohammad Rashid , Hasanzadeh Elahe , Allahyari Maryam , Moghadam Reza Rezvani , Asadiyan-Sobhan Parisa , Sharifan Payam , Afkhami Nafiseh , Varaste Naiemeh , Ferns Gordon , Mobarhan Majid Ghayour 
Published: January 2022

Abstract
Background: Due to high inflammation and mental health disorders in Covid-19 patients, we aimed to investigate the relationship between blood inflammatory markers such as WBC, RDW, NLR and PLR and psychological function in COVID-19 patients.Method: The current cross-sectional study and psychological function and a complete blood count (CBC) were measured on 120 COVID-19 patients aged >30 years from the Imam Reza hospital in Mashhad, Iran. Depression, anxiety and stress of participants were evaluated using DASS questionnaire. Also Quality of life, insomnia and sleep quality were measured via SF-36, Insomnia Severity Index and Pittsburgh Sleep Quality Index questionnaire, respectively.Result: No blood parameters were significantly associated with depression, sleep disorders and quality of life (P>0.05), but in MCHC, WBC and PLR anxiety showed a significant relationship (p<0.05). In the stress subgroup, only RPR was associated with stress (p<0.05). In linear regression between hematological parameters and psychological score indicated that RDW and PLR were significantly associated with depression (p=0.045 and 0.016 respectively) and anxiety scores (p=0.038 and 0.010 respectively). PLR was also associated with stress (p=0.012).Conclusion: This study showed a positive association between depression/anxiety/stress symptoms and levels of hematological inflammatory markers including PLR and RDW.
Three-level Model for Opinion Aggregation under Hesitance
Authors: Zapletal Frantisek , Hudec Miroslav , Švaňa Miloš , Němec Radek 
Published: January 2022

Abstract
Valuable information for decision making can be obtained by collecting and analyzing opinions from diverse stakeholder or respondent groups, which usually have different backgrounds and are variously affected by the topics under survey. For this to succeed, it is necessary to manage the uncertainty of respondents’ opinions, different number of filled questionnaires among groups, different number of questions for each stakeholder group, and relevance of subsets of respondent groups. This work proposes handling the hesitance of respondents’ opinions for the rating scale questions. To evaluate the collected opinions, a three-level aggregation model is developed. In the first level, the overall opinion of each respondent is computed as a mean of fuzzy numbers covering uncertain answers and their respective hesitance. In the second level, stakeholder groups are considered as a whole. Aggregation by a relative quantifier is applied to calculate the validity of a proposition the majority of respondents have a positive or negative opinion . At the third level, the consensus among diverse subsets of stakeholder groups is calculated considering the relevance of each group independently as well as their so-called coalitions by Choquet integral. Finally, the proposed model is illustrated by a real-life case study.
Unplanned Reoperation After Percutaneous Endoscopic Discectomy For Lumbar Disc Herniation:A Clinical Report From China
Authors: Wu Hai-ting , Pang Qingjiang , Wang Yun 
Published: January 2022

Abstract
Objective: To investigate the causes of unplanned reoperation after percutaneous endoscopic discectomy for lumbar disc herniation.Methods: 853 patients with lumbar disc herniation were treated by percutaneous endoscopic discectomy in Hwa Mei hospital from January 2018 to June 2021, of which 18 patients received unplanned reoperation. There were 7 males and 11 females, aged from 38 to 72, with an average of (56.8 ±11.3) years. There were 1 case of segment L3/4, 11 cases of segment L4/5, and 1 case of segment L3/4+L4/5. The follow-up time after reoperation ranged from 1 to 35 months, with an average of 8.5 months. VAS score, ODI index and MacNab criteria were adopted to evaluate the curative effect of the initial and revision operation. We made a descriptive analysis of the clinical data of patients with unplanned reoperation, so as to summarize the poor curative effect after percutaneous endoscopic surgery and the reasons for reoperation.Results: A total of 18 patients with unplanned reoperation were collected, of which 2 patients received twice unplanned reoperation. All the 18 cases had ipsilateral herniation, including ipsilateral herniation in 17 cases and contralateral protrusion in 1 case. The methods of reoperation: 13 cases of PELD, 4 cases of decompression and internal fixation (PLIF×1, TLIF×3), 1 case of MED, 1 case of Endo-LIF, and 1 case of debridement. The causes of reoperation included incomplete decompression (residual nucleus pulposus, residual endplate, residual bone), recurrence, postoperative infection, nerve injury, hematoma, pseudocyst and so on. The follow-up time after reoperation ranged from 1 to 22 months, with an average of 8.61 ±3.52 months. The VAS score of low back pain decreased from 3.27 ±1.24 before operation to 1.21 ±0.32 at the last follow-up, the VAS score of leg pain decreased from 5.12 ±2.15 before operation to 1.98 ±1.20 at the last follow-up. The ODI index decreased from 32 ±16% to 10.4 ±6, and the difference was statistically significant (P < 0.05). At the last follow-up, the clinical efficacy was evaluated according to MacNab criteria (18 cases), including excellent in 14 cases, good in 3 cases, fair in 1 case and poor in 0 cases. The excellent and good rate was 94.4%. ﻿Conclusion: There is the possibility of unplanned reoperation in the removal of nucleus pulposus under PELD. Besides, the appropriate operation method should be chosen according to the specific conditions of the lesion before operation. Incomplete decompression is the main cause of unplanned reoperation after PELD. Other causes include recurrence, infection, hematoma, nerve injury, pseudocyst.
Level of Women-friendly Care Provision Among Mothers in Immediate Post-delivery Period at Public Hospitals of Southeast Ethiopia: a Cross-sectional Study
Authors: Kene Chala , Tekalegn Yohannes , Dibaba Diriba , Abdella Mujib , Fikadu Genet , Atlaw Daniel , Gomora Degefa , Geta Girma , Seyoum Kenbon , Hailu Sintayehu , Ejigu Nuway , Sahiledengle Biniyam , Tasew Alelign 
Published: January 2022

Abstract
Background: Providing good-quality care is one of the most effective ways of ensuring that maternal health services are used and that women's lives are saved. This quality care can be achieved through improving the women-friendly care services. The women-friendly approach focuses on women’s rights to have access to quality care for themselves as individuals, as mothers, and for their infants. However, access to quality health services is not guaranteed for many women, particularly in low and middle-income countries. This study aimed to assess the level of women-friendly care provision and associated factors among mothers in the immediate post-delivery period at public hospitals of Bale Zone, Southeast Ethiopia 2021. Methods: An institutional-based cross-sectional survey was employed among mothers in the immediate post-delivery period in public hospitals of Bale Zone from March 1-30, 2021. A total of 363 mothers in the immediate postnatal period were included in this study. To recruit the study participants a systematic random sampling technique was used. Data was collected through pre-tested structured questioners. After checking for completeness, the data were entered into Epi Data version 4.6.2.0 and exported to SPSS version 26.0 for analysis. The bivariate and multivariable logistic regression model was fitted to identify factors associated with a level of women-friendly care provision. Odds ratio with 95 % confidence interval was computed to determine factors independently associated with outcome. Results: The level of women-friendly care provision among mothers in immediate post-delivery at public hospitals of Bale Zone was found to be 61% [95%CI (55.73-66.04)]. Being prim para mother [AOR=1.88(1.07-3.33)], having planned pregnancy [AOR= 1.94(1.04-3.63)] and staying at a health facility after delivery [AOR=4.8(1.71-13.39)] were found to be statistically significant predictors of level of women-friendly care provision. Conclusion: The women-friendly care provision among mothers in the immediate post-delivery period at this study area was found to be low. All staff should be cooperative to provide good women-friendly care provision in health facilities.
Osimertinib plus Bevacizumab Improve the Outcome of Leptomeningeal Metastasis Patients with EGFR Mutant Non-Small-Cell Lung Cancer
Authors: yi yali , Cai Jing , Xu Peng , Xiong Le , Lu Zhiqin , Zeng Zhimin , Liu Anwen 
Published: January 2022

Abstract
Background

EGFR-mutant non-small cell lung cancer (NSCLC) is prone to leptomeningeal metastasis (LM) after Tyrosine kinase inhibitors (TKIs) treatment. Our previous study suggested that osimertinib plus bevacizumab was safe and effective in LM from EGFR-mutant lung cancer. This study aimed to compare the efficacy of osimertinib plus bevacizumab with osimertinib in EGFR-mutant NSCLC patients with LM.
Methods

We retrospectively reviewed data from 27 LM patients with EGFR-mutant lung cancer who received osimertinib with or without bevacizumab at the Second Affiliated Hospital of Nanchang University. Next, we investigated the antitumor efficacy of osimertinib plus bevacizumab in an LM xenograft model using the H1975 (EGFR exon20 T790M and exon21 L858R) cell line. We examined the ability of osimertinib plus bevacizumab compared with osimertinib to penetrate the blood-brain barrier (BBB) and explored the potential mechanism.
Results

Our retrospective study observed the improved survival of LM patients in osimertinib plus bevacizumab group. The median overall survival (OS) of the patients who received osimertinib and bevacizumab (n = 16) compared with osimertinib (n=11) was 18.0 months versus 13.7 months (log-rank test, p=0.046, HR=2.867, 95%CI:1.007-8.162). The median intracranial Progression-free Survival (iPFS) was 10.6 months versus 5.5 months (log-rank test, p=0.037, HR=3.401, 95%CI:1.079-10.720). In the LM xenograft model with H1975 cells, the combined treatment significantly increased the effective intracranial concentration of osimertinib, modulated the level of E-cadherin and downregulated the levels of EGFR and downstream signaling pathways including p-AKT and reduced tumor microvessel density (TMD), indicated that combined osimertinib with bevacizumab play a synergistic effect in EGFR-mutant LM model possibly by modulating the level of E-cadherin.
Conclusions

Our findings indicate that osimertinib plus bevacizumab tend to improve the outcome of LM patients with EGFR-mutant NSCLC than osimertinib.
Knowledge and Practices on Consumption of Free-Range Chicken Viscera in Selected Rural Communities of Kwazulu-Natal, South Africa, with Focus on Zoonotic Transmission of Toxoplasma Gondii and Toxocara Spp.
Authors: Omonijo Adejumoke Oluwatosin , Mukaratirwa Samsom 
Published: January 2022

Abstract

Free-range chickens (FRC) are a host to a variety of pathogens of zoonotic and economic importance which includes Toxoplasma gondii and Toxocara spp among others. Humans acquire infections via the ingestion of infective stages of T. gondii and Toxocara spp with raw or undercooked food. This study aimed to assess knowledge and practices on the household consumption of FRC meat and viscera by rural communities in KwaZulu-Natal (KZN), South Africa as risk factors in the transmission of zoonotic pathogens. A descriptive cross-sectional study was conducted among twenty (20) randomly selected households in each selected community on the northern coast (Gingindlovu and Ozwathini) and southern coast (uMzinto and Shongweni) of KZN province. An adult from each household was interviewed on FRC consumption practices using a semi-structured questionnaire. Data were analyzed using statistical package for social sciences (SPSS) version 25.0. Descriptive, and Chi-square statistics were used to assess knowledge and practices related to FRC consumption and zoonoses transmission. Knowledge of zoonosis transmission was estimated at (31.3%, 25/80) in the four localities and a significant association was found between the educational level of respondents and study locations (p<0.05). Knowledge was highest among respondents with a high school education (13.75%, 11/80) and lowest (1.3%, 1/80) among respondents with no formal education. Overall, over three-quarters (76.3%, 61/80) of respondents reported chicken viscera consumption although majority (96.7%, 59/80) preferred eating them ‘well-cooked’. This result underscores the need to intensify awareness on health risk associated with the consumption of raw/undercooked viscera from free-range chickens.
A method for chemical and physical modification of oriented pulp fibre sheets
Authors: Forsberg Diana Carolina Reyes , Westin Per-Oskar , Li Lengwan , Svedberg Anna , Grundberg Hans , Berglund Lars A. 
Published: January 2022

Abstract
Wood pulp fibres are promising reinforcements for biocomposites due to their renewable resource origin and mechanical properties. An oriented and dense fibre reinforcement structure is beneficial for biocomposite properties. We present a method of modifying fibres (e.g. to increase strain to failure) in pre-formed oriented high-density paper structures intended for biocomposites or as hot-pressed fibre materials. Mildly delignified, well-preserved holocellulose fibres from softwood are used. Cold alkali treatment (hemicellulose removal) and mercerisation (conversion to cellulose II) were carried out successfully on oriented fibre sheets. Controlled anisotropy and sheet density are achieved from untreated and straight fibres in the sheet formation step. High mechanical properties and increased ductility of mercerised sheets were observed, which may be valuable for hot-pressed fibre materials (E ≈ 7.1 GPa, strength of 108 MPa and strain to failure of 5.3%) and biocomposites. In contrast, modified wood pulp fibres were difficult to orient, resulting in higher sheet porosity and weak interfibre bonding.
Temporal Variation of Floral Reward can Improve the Pollination Success of a Rare Flowering Plant
Authors: Benadi Gita , Kögel Raphael , Lämsä Juho , Gegear Robert J. 
Published: January 2022

Abstract
Many pollinating animals visit a variety of flowering plant species. Rare plant species pollinated by such generalists may experience a low quality or quantity of pollination, depending on the pollinators' foraging behaviour. How plants cope with this rarity disadvantage is not well understood. One possibility would be to offer a higher floral reward, for example a higher nectar sugar concentration. However, since nectar production is costly, rare plants may only be able to increase their nectar concentration for a limited time and offer little reward afterwards. In this study we performed a laboratory experiment with bumblebees (Bombus terrestris) foraging on artificial flowers of two colours to investigate whether the bees' foraging behaviour produces a rarity disadvantage and if so, whether the rare flower type could improve its pollination success through temporal variation of its nectar sugar concentration, i.e. a temporary increase of nectar sugar followed by a period with low concentration. We found that when both flower colours offered equal rewards, the rare colour received only slightly fewer visits per flower, but had a considerably lower expected pollination success based on the bumblebees' visitation sequences. Temporal variation of the rare colour's sugar concentration increased both the quantity and quality of visits it received. This positive effect was reduced when there were fewer rare flowers or when two bumblebees foraged simultaneously. Our results suggest that temporal variation of floral rewards can alleviate, but not completely eliminate the rarity disadvantage.
Plant Species Modulate Plant-Mediated Indirect Effects of Orius Sauteri on Pests Frankliniella Occidentalis and Bemisia Tabaci
Authors: Di Ning , Zhu Zhengyang , Harwood James D. , Xu Zhigang , Wang Su , Desneux Nicolas 
Published: January 2022

Abstract
Exploring the interactions between host plants, herbivores and natural enemies is an important experimental approach to enhance biological control and induced plant defense responses following infestation by herbivores could enable plants to minimize damage. Orius sauteri (Poppius), an important generalist predator, has been widely used as a biological control agent for suppressing many agricultural pests on agronomic and horticultural crops. It is also documented as ovipositing eggs in plant tissues and piercing and sucking as omnivorous predator. We therefore explored the fitness parameters of primary (western flower thrips) and secondary pests (whiteflies) on three different plant species pre-inoculated by O. sauteri. Pre-inoculation of O. sauteri significantly reduced the survival of Frankliniella occidentalis (Pergande) on tomato and Bemisia tabaci (Gennadius) on cowpea. The reproduction of B. tabaci on tomato, cucumber and cowpea was affected by O. sauteri in a different manner. The presence of O. sauteri significantly reduced the reproduction of F. occidentalis on tomato and cucumber plants, but there was no significant effect on cowpea plants. This demonstrates that plants with the pre-inoculation of O. sauteri decrease the performance of herbivores on different plant species but to differing degrees. These results further enhance our knowledge of ecological relationships between natural enemies and herbivores, and provide the context for the early release of natural enemies to control pests.