bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Combined Embolization and Radiofrequency Ablation in Stage 1 Renal Cell Carcinomas
Authors: Wessendorf Joel , König Alexander Marc , Heers Hendrik , Mahnken Andreas H. 
Published: March 2022

Purpose To retrospectively evaluate outcomes of a combined interventional approach to stage 1 (cT1cN0cM0) renal cell carcinomas (RCCs) by transarterial embolization (TAE) followed by percutaneous CT-guided radiofrequency ablation (RFA) in patients ineligible for surgery.
Materials and Methods 13 patients (9 male, 4 female, 69.6 ± 16.6 y/o) with 14 RCCs (largest diameter: 40.4 ± 6.7 mm, cT1a: 4, cT1b: 10) were treated by RFA a median of one day after TAE in a single center. Indications for minimally invasive interventional therapy were bilateral RCCs (n = 4), RCCs in a single kidney after nephrectomy (n = 3), increased surgical risk due to comorbidities (n = 4), and rejection of surgical therapy (n = 2). Technical success, effectiveness, safety, ablative margin, cancer-specific survival, overall survival, and tumor characteristics were analyzed.
Results All RCCs were successfully ablated after embolization with a minimum ablative margin of 1.2 mm. The median follow-up was 27 (1–83) months. There was no residual or recurrent tumor in the ablation zone. No patient developed metastasis. Two minor and two major complications occurred. Four patients with severe comorbidities died during follow-up due to causes unrelated to therapy. The 1-year and 5-year overall survival was 74.1 % each. Cancer-specific survival was 100 % after 1 and 5 years. There was no significant decline in mean eGFR directly after therapy (p = 0.226). However, the mean eGFR declined from 62.2 ± 22.0 to 50.0 ± 27.8 ml/min during follow-up (p < 0.05).
Conclusion The combination of TAE and RFA provides an effective minimally invasive therapy to stage 1 RCCs in patients ineligible for surgery. The outcomes compare favorably with data from surgery.
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Multiparametric Functional MRI of the Kidney: Current State and Future Trends with Deep Learning Approaches
Authors: Zhang Cecilia , Schwartz Martin , Küstner Thomas , Martirosian Petros , Seith Ferdinand 
Published: March 2022

Background Until today, assessment of renal function has remained a challenge for modern medicine. In many cases, kidney diseases accompanied by a decrease in renal function remain undetected and unsolved, since neither laboratory tests nor imaging diagnostics provide adequate information on kidney status. In recent years, developments in the field of functional magnetic resonance imaging with application to abdominal organs have opened new possibilities combining anatomic imaging with multiparametric functional information. The multiparametric approach enables the measurement of perfusion, diffusion, oxygenation, and tissue characterization in one examination, thus providing more comprehensive insight into pathophysiological processes of diseases as well as effects of therapeutic interventions. However, application of multiparametric fMRI in the kidneys is still restricted mainly to research areas and transfer to the clinical routine is still outstanding. One of the major challenges is the lack of a standardized protocol for acquisition and postprocessing including efficient strategies for data analysis. This article provides an overview of the most common fMRI techniques with application to the kidney together with new approaches regarding data analysis with deep learning.Methods This article implies a selective literature review using the literature database PubMed in May 2021 supplemented by our own experiences in this field.Results and Conclusion Functional multiparametric MRI is a promising technique for assessing renal function in a more comprehensive approach by combining multiple parameters such as perfusion, diffusion, and BOLD imaging. New approaches with the application of deep learning techniques could substantially contribute to overcoming the challenge of handling the quantity of data and developing more efficient data postprocessing and analysis protocols. Thus, it can be hoped that multiparametric fMRI protocols can be sufficiently optimized to be used for routine renal examination and to assist clinicians in the diagnostics, monitoring, and treatment of kidney diseases in the future.Key Points: Citation Format
Recent Advances to Mediate Reductive Processes of Nitroarenes Using Single-Electron Transfer, Organomagnesium, or Organozinc Reagents
Authors: Driver Tom G. , Zhu Haoran 
Published: March 2022

AbstractNitroarenes are readily available compounds that are commonly utilized in reductive processes to form C–NAr bonds via reactive nitrogen intermediates. Recent advances in the development of reductive reactions of nitroarenes using organomagnesium, organozinc, and single-electron transfer reagents are discussed within this short review. 1	Introduction2	Organomagnesium-Mediated Reductive Reactions of Nitroarenes3	Organozinc- and Zinc-Mediated Reductive Reactions of Nitroarenes4	Iodine-Catalyzed Redox Cyclizations of Nitroarenes5	Titanium(III)-Mediated Reductive Cyclizations6	Sulfur-Mediated Reductive Reactions of Nitroarenes7	Alkoxide-Mediated Reductive Reactions of Nitroarenes8	4,4′-Bipyridine-Mediated Reductive Reactions of Nitroarenes9	Visible-Light-Driven Reductive Amination Reactions10	Electrochemical Reductive Reactions11	Conclusion
Agile, Easily Applicable, and Useful eHealth Usability Evaluations: Systematic Review and Expert-Validation
Authors: Sinabell Irina , Ammenwerth Elske 
Published: March 2022

Abstract
Background Electronic health (eHealth) usability evaluations of rapidly developed eHealth systems are difficult to accomplish because traditional usability evaluation methods require substantial time in preparation and implementation. This illustrates the growing need for fast, flexible, and cost-effective methods to evaluate the usability of eHealth systems. To address this demand, the present study systematically identified and expert-validated rapidly deployable eHealth usability evaluation methods.
Objective Identification and prioritization of eHealth usability evaluation methods suitable for agile, easily applicable, and useful eHealth usability evaluations.
Methods The study design comprised a systematic iterative approach in which expert knowledge was contrasted with findings from literature. Forty-three eHealth usability evaluation methods were systematically identified and assessed regarding their ease of applicability and usefulness through semi-structured expert interviews with 10 European usability experts and systematic literature research. The most appropriate eHealth usability evaluation methods were selected stepwise based on the experts' judgements of their ease of applicability and usefulness.
Results Of these 43 eHealth usability evaluation methods identified as suitable for agile, easily applicable, and useful eHealth usability evaluations, 10 were recommended by the experts based on their usefulness for rapid eHealth usability evaluations. The three most frequently recommended eHealth usability evaluation methods were Remote User Testing, Expert Review, and Rapid Iterative Test and Evaluation Method. Eleven usability evaluation methods, such as Retrospective Testing, were not recommended for use in rapid eHealth usability evaluations.
Conclusion We conducted a systematic review and expert-validation to identify rapidly deployable eHealth usability evaluation methods. The comprehensive and evidence-based prioritization of eHealth usability evaluation methods supports faster usability evaluations, and so contributes to the ease-of-use of emerging eHealth systems.
Perinatal Carbon Monoxide Poisoning: Treatment of a 2-Hour-Old Neonate with Hyperbaric Oxygen
Authors: Kreshak Allyson A. , Lawrence Shelley M. , Ontiveros Sam T. , Castellano Tiffany , VanHoesen Karen B. 
Published: March 2022

AbstractA 41-year-old gravida 4 para 3 (G4P3) and 385/7 weeks pregnant woman presented to labor and delivery with dizziness, headache, and decreased fetal movement after 12 hours of exposure to carbon monoxide (CO) from a grill that was used inside for heat. The mother was hemodynamically stable, and her neurologic examination was intact. Her carboxyhemoglobin level, which was obtained 12 hours after removal from the CO exposure, was 7.4%. The fetus's heart rate was 173 beats per minute with moderate variability and one late appearing deceleration, not associated with contractions. The biophysical profile score was 2 of 8. The obstetrics team performed a routine cesarean section. The 1- and 5-minute Apgar's scores were 7 and 8, respectively. The arterial cord gas result was as follows: pH = 7.05, PCO2 = 71 mm Hg, pO2 = 19 mm Hg, bicarbonate = 14 mmol/L, and carboxyhemoglobin = 11.9%. The mother and infant were treated with hyperbaric oxygen therapy consisting of 100% oxygen at 2.4 atmosphere absolutes (ATA) for 90 minutes at 2.5 hours after delivery. Following one hyperbaric oxygen treatment, the infant was transitioned to room air and routine postpartum treatment and was discharged 3 days later in good condition. Hyperbaric oxygen treatment was well tolerated in this neonate.
Doppler evaluation of recipient cows treated with progesterone and estradiol
Authors: Guedes Pedro Henrique Evangelista , Pinna Aline Emerim , Morais Rita de Cássia Lima , de Souza Guilherme Nunes , Jacob Julio Cesar Ferraz , Carvalho Carla Fernanda Paranhos de Moura , Nogueira Luiz Altamiro Garcia , Oliveira Clara Slade 
Published: March 2022

Context Due to the advances in the field of biotechnology of reproduction, success rates in embryo transfer (ET) programs have been growing continuously. Such rates are influenced by several factors, among which fertility and success in synchronising the estrus of the recipients stand out. Doppler ultrasound is emerging as a useful tool fot the assessment of fertility in recipients and for the early diagnosis of pregnancy. Aims This study aimed to verify whether luteal vascularisation, uterine haemodynamics and corpus luteum (CL) volume, evaluated only on the day of fixed-time ET (FTET), are useful parameters for the selection of Girolando recipients synchronised with progesterone and estrogen. Methods Girolando recipients received a hormonal protocol for FTET and were evaluated on the day of embryo transfer by B-mode and Doppler ultrasonography. The volume of the CL, the side of the CL, the estimation of luteal vascularisation and the Doppler indexes of the right and left uterine arteries were evaluated in real time. The ultrasound images were saved and used for later pixel counting and determination of the vascularised luteal area using specific software. Blastocysts (n = 92) produced in vitro (IVF) with Grade 1 morphology on Day 7 of development were transferred to all animals with corpus luteum. The pregnancy diagnosis was made 24 days after embryo transfer and the animals were separated into two groups, namely, pregnant and non-pregnant. Key results Retrospective analyses of luteal vascularisation; haemodynamics of uterine arteries and corpus luteum volume did not differ (P > 0.05) between the groups. The means of the Doppler indexes of the uterine arteries were not affected (P > 0.05) by the presence of CL ipsilateral to the assessed vessel. Conclusions It is concluded that the assessments of uterine haemodynamics, size and vascularisation of the CL, through Doppler ultrasonography on the day of ET, under the proposed conditions, were not useful to predict recipients with greater chances of establishing pregnancy. Implications Although Doppler is a useful tool for real-time fertility assessment, its accuracy if affected by protocols that do not guarantee synchrony between ovulation times. This suggests that other fertility assessment methods be used under these field conditions.
Cross-linkers at growing microtubule ends generate forces that drive actin transport
Authors: Alkemade Celine , Wierenga Harmen , Volkov Vladimir A. , Preciado López Magdalena , Akhmanova Anna , ten Wolde Pieter Rein , Dogterom Marileen , Koenderink Gijsje H. 
Published: March 2022

SignificanceComplex cellular processes such as cell migration require coordinated remodeling of both the actin and the microtubule cytoskeleton. The two networks for instance exert forces on each other via active motor proteins. Here we show that, surprisingly, coupling via passive cross-linkers can also result in force generation. We specifically study the transport of actin filaments by growing microtubule ends. We show by cell-free reconstitution experiments, computer simulations, and theoretical modeling that this transport is driven by the affinity of the cross-linker for the chemically distinct microtubule tip region. Our work predicts that growing microtubules could potentially rapidly relocate newly nucleated actin filaments to the leading edge of the cell and thus boost migration.
Recent advances in printed liquid metals for wearable healthcare sensors: a review
Authors: Liu Longhui , Huang Han , Wang Xincheng , He Pei , Yang Junliang 
Published: March 2022

Abstract
Wearable healthcare sensors can perform real-time health monitoring by tracking various physical signals, physiological signals, as well as electrophysiological activities of the human body. Liquid metals have become an ideal candidate material for wearable healthcare sensors due to their excellent physical and chemical properties, such as high stretchability, high electrical and thermal conductivity, as well as great biocompatibility. Printing techniques present the possibility to fabricate economically efficient, versatile, low-cost and large-area functional electronic devices based on liquid metals. A series of wearable sensors based on liquid metals through printing processes have been designed and reported. Herein, we present a review on the recent advances in printed liquid metals toward wearable healthcare sensors. A detailed landscape view on the properties of liquid metals is provided, following by the overview of printing methods, including direct writing, screen printing, inkjet printing, acoustophoretic printing and 3D printing. Sensor devices (e.g. pressure sensors, strain sensors, temperature sensors, and electrochemical sensors) employed for wearable healthcare monitoring are summarized. Finally, the key challenges and opportunities of the printed sensors based on liquid metals in personalized healthcare monitoring and human-machine interfaces are also discussed.
Safety assessments undertaken using the BIOMASS methodology: lessons learnt and methodological enhancements
Authors: Lindborg Tobias , Brown Joanne , Griffault Lise , Ikonen Ari T K , Kautsky Ulrik , Sanae Shibutani , Smith Graham , Smith Karen , Thorne Mike , Walke Russell 
Published: March 2022

Abstract
The International Atomic Energy Agency has coordinated an international project addressing enhancements of methods for modelling in post-closure safety assessments of solid radioactive waste disposal. The project used earlier published work from the IAEA biosphere modelling and assessment (BIOMASS) project to further develop methods and techniques. The task was supported by a parallel on-going project within the BIOPROTA forum. The output from the project is described in detail in a forthcoming IAEA report. Here an overview of the work is given to provide researchers in the broader fields of radioecology and radioactive waste disposal with a summarised review of the enhanced BIOMASS methodology and the work that has been undertaken during the project. It is hoped that such dissemination will support and promote integrated understanding and coherent treatment of the biosphere component within the overall assessment process. The key activities undertaken in the project were: review and identification of those parts of the original BIOMASS methodology that needed enhancement, discussions on lessons learned from applying the BIOMASS method, using real examples to assess the methodology and its usefulness, and writing of those parts of the methodology that were considered could benefit from refinement or for which new guidance was required to take account of scientific developments. The work has shown that the overall approach in the original BIOMASS methodology has proven sound. However, the enhanced version clarifies the need for an iterative and holistic approach with system understanding central to the approach. Specifically, experience, especially in site-specific contexts, has emphasised that adequate system understanding is essential in underpinning safety assessments for radioactive waste disposal. The integral role of the biosphere within safety assessment is also emphasised in the enhanced methodology.
Multi-layer model aided inertial navigation system for unmanned ground vehicles
Authors: Du Binhan , Shi Zhiyong , Wang Huaiguang , Han Lanyi , Song Jinlong 
Published: March 2022

Abstract
The inertial navigation system (INS) has been commonly adopted for unmanned ground vehicles, but it needs other systems to correct for error divergence, such as the Global Navigation Satellite System (GNSS). However, GNSS failures are inevitable, and INS must navigate independently in such situations, meaning that navigation errors will diverge fast. To solve this problem, the vehicle model aided INS is proposed. In this paper, three commonly used vehicle models are analyzed, first to discuss their disadvantages, that they contain the vehicle kinematics model (VKM), the non-holonomic constraint of VKM, and the vehicle dynamics model (VDM). Against their disadvantages, the multi-layer vehicle model aided INS is proposed. The proposed method divides the INS error parameters into the sensor layer, system layer I, and system layer II. Then, the navigation information from the INS is fused with our developed VKM and VDM at the system layer and the sensor layer respectively. Additionaly, the design of the adaptive Kalman filter is based on the VKM error model, such that the estimations can be protected from observation errors when the VKM accuracy declines. Compared to the traditional vehicle model aided INS, the proposed method can improve the accuracy and robustness of the navigation system with acceptable computational complexity.
Structural and electronic properties of double-walled G-C3N4 nanotubes: a density functional theory study
Authors: Li Lijian , Zhang Long , Zhao Chen , Zhu Yingtao , Gao Yang 
Published: March 2022

Abstract
In the present work, we investigated the geometric, electronic, and photocatalytic properties of g-C3N4 single-walled nanotube (SWCNNTs) and g-C3N4 double-walled nanotubes (DWCNNTs). The negative strain energy indicates that the SWCNNTs have a stable structure, while the most stable combination in the DWCNNT is (6, 0)@(12, 0). The energy band gaps of (n, 0) SWCNNTs increase while that of (n, n) SWCNNTs decrease as the diameter increase. Moreover, the calculated nanotubes have the ability of photocatalytic water splitting, and the valance band maximum of nanotubes are much lower than that of the monolayer, indicating that the nanotubes have better oxidation capacity than the monolayer. On the other hand, our calculations show that DWCNNTs have type II band alignment with a band gap width significantly smaller than that of SWCNNTs. Interestingly, DWCNNT exhibited a smaller effective mass of electrons than SWCNNTs, which is beneficial to electron migration. Therefore, the construction of nanotube is an effective way to improve the photocatalytic performance of g-C3N4 monolayer materials.
Amplified steady state bifurcations in feedforward networks
Authors: von der Gracht Sören , Nijholt Eddie , Rink Bob 
Published: March 2022

Abstract
We investigate bifurcations in feedforward coupled cell networks. Feedforward structure (the absence of feedback) can be defined by a partial order on the cells. We use this property to study generic one-parameter steady state bifurcations for such networks. Branching solutions and their asymptotics are described in terms of Taylor coefficients of the internal dynamics. They can be determined via an algorithm that only exploits the network structure. Similar to previous results on feedforward chains, we observe amplifications of the growth rates of steady state branches induced by the feedforward structure. However, contrary to these earlier results, as the interaction scenarios can be more complicated in general feedforward networks, different branching patterns and different amplifications can occur for different regions in the space of Taylor coefficients.
194 nm microplasma lamps driven by excitation transfer: optical sources for the 199Hg ion atomic clock and photochemistry
Authors: Park S , Mironov A E , Kim J , Park S-J , Eden J G 
Published: March 2022

Abstract
A series of miniature, microcavity plasma lamps emitting predominantly at 194 nm has been successfully developed and tested as the optical pump for the microwave 199Hg-ion atomic clock (40.507 GHz), replacing low pressure, RF-powered Ar/Hg discharges. Intense fluorescence on the 6p
2P1/2 → 6s
2S1/2 transition of the singly-charged 202Hg ion at 194.23 nm has been generated in arrays of cylindrical microplasmas through electron-impact excitation of He, followed by three-body formation of He2(a
3

Σ

u

+

) and Penning ionization of Hg. Emission spectroscopy and kinetic modeling of He/Hg vapor plasmas demonstrate that the population of the Hg+(62P1/2) radiating state (16.82 eV), produced by direct or two-step electron impact processes, is

<

1% of that generated by excitation transfer to Hg by H

e

2

*

. Flat, fused silica lamps having emitting areas as small as 4 mm2 and containing several mg of 202Hg and 50–800 Torr of He have been fabricated and serve as optical drivers for the Hg+ atomic clock cycle. Based on small arrays of 500 μm–1 mm diameter microcavities, these lamps produce peak and average intensities at 194 nm greater than those associated with the Hg resonance transition at ∼ 254 nm, despite the factor of

>

3 difference between the energies of the 6p
3P1 and 6p
2P1/2 states of neutral Hg and Hg+, respectively. These lamps are unique in the sense that the desired radiating species is an excited ion and the background He gas pressure can reach 1 atm, both of which contribute to a dense glow plasma placing severe demands on E/N, power conditioning, and materials selection. Nevertheless, with proper attention given to design, vacuum processing, and preparation of the lamps, lifetimes above 1500 h have been realized to date. When these lamps drive Jet Propulsion Laboratory Hg+ clocks, the stability floor has been measured to be

∼
10

−14. The implications of this lamp for gas-phase and solid-state photochemistry are also discussed.