bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of transcatheter edge-to-edge mitral valve repair in patients with diabetes mellitus: Results from a real-world cohort
Authors: Kirschfink Annemarie , Alachkar Mhd Nawar , Alnaimi Anas , Vogt Felix , Schroeder Joerg , Lehrke Michael , Frick Michael , Reith Sebastian , Marx Nikolaus , Almalla Mohammad , Altiok Ertunc 
Published: October 2022

Background
There are only limited data on patients with diabetes undergoing transcatheter edge-to-edge repair (TEER) in real-world settings. Previous data indicated patients with diabetes to have a worse prognosis. This study sought to evaluate safety and efficacy of TEER in patients with diabetes in a real-world cohort.

Methods
In this monocentric study 340 consecutive patients with severe primary and secondary mitral regurgitation (MR) undergoing TEER were included. Immediate results of the procedure, intrahospital and one-year outcome were compared between patients with and without diabetes.

Results
Diabetes was present in 109 patients (32%). Patients with diabetes were younger (77 y (71, 81) vs. 79 y (74, 83); p = 0.003), had more often ischemic cardiomyopathy (68% vs. 48%; p<0.001), previous coronary-artery bypass graft (35% vs. 20%; p = 0.002) and arterial hypertension (89% vs. 75%; p<0.001) compared to those without diabetes. Baseline NYHA class, type of MR (primary vs. secondary), left ventricular dimensions and function (ejection fraction: 37% (28, 50) vs. 40% (29, 55); p = 0.10) as well as severity of MR were not different between both groups. Success of the procedure (95% vs. 95%; p = 0.84), intrahospital mortality (5.5% vs. 4.8%; p = 0.98) and one-year follow-up regarding all-cause mortality (24.2% vs. 23.0%; p = 0.72), hospitalization for heart failure (37.4% vs. 31.0%, p = 0.23), NYHA class (p = 0.14) or MR severity (p = 0.59) did not differ between both groups.

Conclusion
Our real-world data suggest that TEER seems to be similarly safe and effective in patients with severe MR and diabetes compared to those without diabetes.
A low rate of end-stage kidney disease in membranous nephropathy: A single centre study over 2 decades
Authors: Storrar Joshua , Gill-Taylor Tarra , Chinnadurai Rajkumar , Chrysochou Constantina , Poulikakos Dimitrios , Rainone Francesco , Ritchie James , Lamerton Elizabeth , Kalra Philip A. , Sinha Smeeta 
Published: October 2022

Introduction
Membranous nephropathy is the commonest cause of nephrotic syndrome in non-diabetic Caucasian adults over the age of 40 years. Primary membranous nephropathy is limited to the kidneys. Clinical management aims to induce remission, either spontaneously with supportive care, or with immunosuppression. Here, we describe the natural history of this condition in a large tertiary centre in the UK.

Methods
178 patients with primary membranous nephropathy were identified over 2 decades. We collected data on demographics, baseline laboratory values, treatment received and outcomes including progression to renal replacement therapy and death. Analysis was performed on the whole cohort and specific subgroups. Univariate and multivariate Cox regression was also performed.

Results
Median age was 58.3 years with 63.5% male. Median baseline creatinine was 90μmol/L and urine protein-creatinine ratio 664g/mol. Remission (partial or complete) was achieved in 134 (75.3%), either spontaneous in 60 (33.7%) or after treatment with immunosuppression in 74 (41.6%), and of these 57 (42.5%) relapsed. Progression to renal replacement therapy was seen in 10.1% (much lower than classically reported) with mortality in 29.8%. Amongst the whole cohort, those who went into remission had improved outcomes compared to those who did not go into remission (less progression to renal replacement therapy [4.5% vs 28%] and death [20.1% vs 67%]. Those classified as high-risk (based on parameters including eGFR, proteinuria, serum albumin, PLA2R antibody level, rate of renal function decline) also had worse outcomes than those at low-risk (mortality seen in 52.6% vs 10.8%, p<0.001). The median follow-up period was 59.5 months.

Conclusion
We provide a comprehensive epidemiologic analysis of primary membranous nephropathy at a large tertiary UK centre. Only 10.1% progressed to renal replacement therapy. For novelty, the KDIGO risk classification was linked to outcomes, highlighting the utility of this classification system for identifying patients most likely to progress.
Homocysteine is associated with higher risks of ischemic stroke: A systematic review and meta-analysis
Authors: Rabelo Nícollas Nunes , Telles João Paulo Mota , Pipek Leonardo Zumerkorn , Farias Vidigal Nascimento Rafaela , Gusmão Rodrigo Coimbra de , Teixeira Manoel Jacobsen , Figueiredo Eberval Gadelha 
Published: October 2022

Background
High levels of homocysteine (Hct) have been associated with great risks of ischemic stroke. However, some controversy still exists. We performed a systematic review and meta-analysis to compare the levels of Hct between patients with ischemic stroke and controls.

Methods
We performed a systematic literature search for articles reporting Hct levels of patients with occurrence of ischemic stroke. We employed a random-effects inverse-variance weighted meta-analytical approach in order to pool standardized mean differences, with estimation of τ2 through the DerSimonian-Laird method.

Results
The initial search yielded 1361 studies. After careful analysis of abstracts and full texts, the meta-analysis included data from 38 studies, which involved almost 16 000 stroke events. However, only 13 studies reported means and standard deviations for cases and controls, and therefore were used in the meta-analysis. Those studies presented data from 5002 patients with stroke and 4945 controls. Standardized mean difference was 1.67 (95% CI 1.00–2.25, P < 0.01), indicating that Hct levels were significantly larger in patients with ischemic stroke compared to controls. Between-study heterogeneity was very large (I2 = 99%), particularly because three studies showed significantly large mean differences.

Conclusion
This meta-analysis shows that patients with ischemic stroke have higher levels of Hct compared to controls. Whether this is a modifiable risk factor remains to be assessed through larger prospective cohorts.
Cymbopogon winterianus, Neurolaena lobata, and Ruta chalepensis—Recurring Herbal Remedies in Guatemalan Maya Q’eqchi’ Homegardens
Authors: Thiel Amanda , Quinlan Marsha B 
Published: October 2022

Abstract We report on the top three ethnopharmacological herbs growing among a lowland Guatemalan Q’eqchi’ community’s homegardens. In a gardening culture characterized by pragmatic species distribution and sharing, these few herbaceous species recur in multiple households’ dooryard gardens. Our aim in reporting on the most predominant ethnobotanical herbs gardened in a Maya Q’eqchi’ village’s dooryards is to valorize the capacities of local pharmacological traditions. Thirty-one walking homegarden interviews and participant-observation inform this research with village residents. Té de limón (Cymbopogon winterianus, for cough, fever), Qa’mank/Tres punta (Neurolaena lobata, for diabetes, fever, headache, gastrointestinal ills, evil eye), and Ruda (Ruta chalepensis, for children’s vomiting, weepiness, evil eye) are the prevalent non-woody Q’eqchi’ homegarden herbs here. Regional ethnomedical and extant pharmacology research mutually support the efficacy and continued practicality of these Q’eqchi’ plant uses. Ethnopharmacological research of Maya Q’eqchi’ medicinals documents local knowledge for conservation and calls for their cultural and biomedical respect as prominent, accessible, therapeutic species.
Resumen Reportamos sobre las tres principales hierbas etnofarmacológicas cultivadas en los huertos familiares de una comunidad Q'eqchi' guatemalteca de tierras bajas. En una cultura de jardinería caracterizada por la distribución pragmática de especies y el intercambio, algunas especies herbáceas se repiten en los huertos familiares de múltiples hogares. Nuestro objetivo al reportar sobre las hierbas etnobotánicas más predominantes cultivadas en los patios de una aldea Maya Q'eqchi' es el de valorizar las capacidades de las tradiciones farmacológicas. Treinta y una entrevistas en base a “caminatas botánicas” y la observación participante informan esta investigación con los residentes de la aldea. Cymbopogon winterianus (para la tos, fiebre), Neurolaena lobata (para la diabetes, fiebre, dolor de cabeza, enfermedades gastrointestinales, mal de ojo) y Ruta chalepensis (para el vómito, el llanto y el mal de ojo en niños) son las hierbas medicinales predominantes. Las investigaciones regionales etnomédicas y farmacológicas actuales apoyan mutuamente la eficacia y la factibilidad de estas plantas y sus usos entre los Q’eqchi’. La investigación etnofarmacológica de las medicinas Maya Q'eqchi' documenta el conocimiento local como base para la conservación e invita al respeto cultural y biomédico de estas como especies terapéuticas destacadas y accesibles.
Human Existence as Individual Creature Based on Robert Frost’s Poems, "Stopping by Woods on a Snowy Evening" and "the Road Not Taken", Through Stylistic View
Authors: Jumino Jumino 
Published: October 2022

Abstract This article deals with human existence as individual creature in the world based on Robert Frost’s poem ”Stopping By Woods on A Snowy Evening” and ”The Road Not Taken”. In doing research, the writer used method of collecting and analyzing data. Observation through document study was used to collect data. While descriptive qualitative method was used to analayze the data. The result shows that both pooems, through poetic device and figurative language used, tell the readers about the responsibilities of human life to do before he os she dies. These may be reponsibilities of any duties and choices in human life. Through the first poem, Robert Frost reminds human being for having forgotten his or her duties in life. Then through the second poem, the poet emphasizes the importaance of making choices and its consequences of the choices. Key words: human existence, creature, life, choice, duty
Using Twitter for Student Learning in Now Era
Authors: Septiani Pinasthika , Nirmala Deli 
Published: October 2022

Twitter is a site that offers a social network of microblogs thus allows users to receive and send messages called tweets. The purpose of this study to examine how social media can influence students in building ideas and motivation for their own learning and to analyse how Twitter affects on knowledge purpose. In this research, the writer uses contructivism theories to know purpose of learning by using Twitter and sample research method to find out how students use Twitter in every aspect of their learning and how effectively this online application for study. After observing this study, the writer can represent using twitter as a media for learning can build the creativity and self-reliance students, also can build their own knowledge.Keywords: contructivism, learning, social media, twitter
GENDERLECT ASPECTS IN COUNTRY SONGS: A PRAGMATIC STUDY
Authors: Garini Ardia , Mualimin Mualimin 
Published: October 2022

A song can be sung by both female and male singers, but some are not. It depends on how the songwriter creates the music lyrics. The songwriter’s gender can also influence the use of the communication style of the lyrics. It is because the way communication between males and females is as different as a culture, appropriates with the term of Genderlect. The goal of this study is to determine the influence of genderlect and the indication of the gendered song in country songs. The data used are country song nominees of Grammy Music Awards 2020. The data are analyzed by presupposition analysis and this study uses purposive sampling and non-participant observation methods for collecting the data. The result of the study shows that genderlect influences the gender of the songwriter, on producing the language of the lyrics. Meanwhile, for the gendered song, it is indicated by the singer who sings the lyrics or the language of the song. Keywords: genderlect; gendered country song; presupposition analysis
REPRESENTATION OF ANXIETY IN THE THING AROUND YOUR NECK BY C. N. ADICHIE (A STUDY OF TRANSITIVITY)
Authors: Yahya Avissa Chaerinda , Nirmala Deli 
Published: October 2022

This study discusses a short story entitled The Thing Around Your Neck by Chimamanda Ngozi Adichie. The purpose of writing this study started from the curiosity of the researcher to find out the anxiety that is reflected in the contents of the short story. As stated in the title of the story, The Thing Around Your Neck, the word thing is described as a symbol of anxiety experienced by the narrator, Akunna. Akunna is one of the main characters in the short story. She is described as a Nigerian-women who is traumatized by her life in America, exhibiting many psychological problems in the form of anxiety. Akunna shows worry, loneliness, helplessness in all life situations that she has to live in. The aims of this study are: 1) to conduct a transitivity analysis to find out how much anxiety is depicted in the story; 2) to explain the anxiety that occurs in the story. The researcher applies descriptive qualitative methods in conducting research and used a non-participant observation method as the data collection method. The data analysis that the researcher used in this study is referential technique. The results of the study show that: 1) there are 5 transitivity processes that represent anxiety in the story, 2) Akunnas' anxiety is caused by the helplessness and stereotypes she receives from the people around her, both Africans and Americans. Keywords: Systemic Functional Linguistics; Anxiety; Short Story; Transitivity
Language Functions Used by The Main Characters of The Marriage Story Movie
Authors: Sanastia Shely Martha , Candria Mytha 
Published: October 2022

People use different utterances by considering the social context in which communication takes place. An utterance may have more than one meaning and function depending on social context and other factors. This study aims to describe the spoken language functions of the main characters, Charlie and Nicole, in the Marriage Story movie. This descriptive qualitative research used Roman Jacobson’s language function classification to categorize the selected utterances found in Marriage Story movie into one of the six functions (emotive, conative, referential, metalingual, phatic, and poetic). To interpret the classified data and the contexts or situations, I relate the language functions to social factors and social dimensions based on Holmes’ categorization. The results show that all six language functions appeared in Nicole and Charlie’s utterances. The data analysis depicts that emotive function is predominantly used by the main characters throughout the whole movie. Moreover, those language functions are influenced by social factors and social dimensions.Keywords: language function; social factor; social dimension; Marriage Story.
The Non-kinetic Origins of Aristotle’s Concept of Ἐνέργεια
Authors: Chame Santiago 
Published: October 2022

AbstractIn this paper, I argue that Aristotle was already aware in his earlier texts of the fundamental distinction between motion and activity and of the criterion which structures this contrast. Moreover, I will present textual evidence which suggests that Aristotle’s original concept of ἐνέργεια applies primarily to activities which contain their ends in themselves, and not to motions, which are different from their ends.
The literary commentary in Sanskrit as metalinguistic communication
Authors: Patel Deven M. 
Published: October 2022

Abstract
Although discernible, if only impressionistically, to most who have read commentaries along with Sanskrit kāvya, links between features of everyday communication and the commentarial format merit an explicit highlighting, especially with respect to their mutual utilization of metalanguage to effectively convey intended messages on a semantic and pragmatic level. Traditional and modern scholars who have reflected upon and practiced interpretation, particularly scriptural hermeneutics and grammatical analysis, have brought wide attention to the varied metalinguistic devices and cultural pragmatics that go into shaping a commentarial tradition of cherished foundational works on Veda, buddhavacana, Jain sūtra, vyākaraṇa, and any number of traditions of philosophical śāstra. This paper builds on some of this reflection to specifically address metalinguistic features that characterize the kāvya commentary in Sanskrit. Among these features include discursive processes to underscore complex semantic sense in poetry as well as to reproduce or reveal pragmatic interactive contexts within which kāvya is read.
Schlechte Angewohnheiten
Authors: Zambrana Rocío 
Published: October 2022

AbstractRecent discussions of Hegel’s conception of second nature, specifically focused on Hegel’s notion of habit, have greatly advanced our understanding of Hegel’s views on embodied normativity. This essay examines Hegel’s account of embodied normativity in relation to his assessment of good and bad habits. Engaging Hegel’s account of the rabble in the Philosophy of Right and Frank Ruda’s assessment of Hegel’s rabble, this essay traces the relation between ethicality, idleness and race in Hegel. In embodying a position of refusal in its affirmation of idleness, the rabble disallows the progressive revision of the project of modernity central to Hegel’s philosophy. Hegel’s discussion of the rabble is thus key to assessing the production of race within Hegel’s notion of ethical life.
An optimal growth pattern during pregnancy and early childhood associates with better fertility in men
Authors: Laru Johanna , Ojaniemi Marja , Franks Stephen , Järvelin Marjo-Riitta , Korhonen Elisa , Piltonen Terhi T , Sebert Sylvain , Tapanainen Juha S , Morin-Papunen Laure 
Published: October 2022

Abstract

Objective
This study aimed to evaluate the association between birth weight (BW), childhood and adolescent BMI, with reproductive capacity in men.

Design
A prospective, population-based cohort study (Northern Finland birth cohort 1966).

Methods
Around 6196 men born in 1966 were followed from birth to age 50 years. Weight and height were measured repeatedly by professionals. Reproductive capacity (infertility assessment, male factor infertility and infertility treatment by age 46 years) was evaluated by questionnaires at ages 31 and 46 years. The number of children by the age of 50 years was recovered from registers. After excluding the men who reported never having attempted to have children or not answering the question at age 31 or 46 years (n = 2041), 4128 men were included in the final study population. Results were adjusted for BW, BW for gestational age (GA), mother's smoking status, marital status, educational level and smoking status.

Results
Being small for GA (10.5% vs 8.2%, P = 0.012) or having a lower BW (3495 g vs 3548 g, P = 0.003) were associated with childlessness. The association was however no longer significant after adjusting for marital status. Being underweight in early childhood was associated with an increased risk of infertility assessment (adjusted, aOR: 2.04(1.07–3.81)) and childlessness (aOR: 1.47(1.01–2.17)) compared to the normal weight group. Conversely, overweight or obesity in early childhood was associated with a decreased risk of infertility assessment (aOR: 0.60 (0.41–0.87)), treatment (aOR: 0.42 (0.25–0.70)) and male factor infertility (aOR: 0.45 (0.21–0.97)). BMI in mid-childhood or puberty had no association with infertility or childlessness.

Conclusion
In boys, an optimal growth trajectory during pregnancy and early childhood seems to be very important for life-long fertility.
COVID-19: First wave impacts on the Charitable Food Sector in Manitoba, Canada
Authors: Slater Joyce , Riediger Natalie , Pilli Bhanu , Mann Kelsey , Derksen Hannah , Penner Avery L. , Perchotte Chantal 
Published: October 2022

The first wave of the COVID-19 pandemic led to significant socioeconomic changes in Canada due to business and school closures, and related job losses. This increased food insecurity among vulnerable populations, as well as many who had not been previously food insecure, placing unprecedented demand on charitable food organizations. This study documented the pandemic’s impact on charitable food organizations in Manitoba, Canada during the first wave in spring 2020. Using a multi-method design, data on pandemic-related program challenges and newly implemented policies/procedures were collected from: food bank organization websites and Facebook pages; online news media outlets; and semi-structured interviews with food organization leadership. Inductive thematic analysis was used to identify emerging patterns and themes. Second level coding was used to integrate data from different sources. Six challenge themes emerged: increased need for services; acquisition and distribution of food supply; staff and volunteer resource management; emotional vulnerability of staff, volunteers, and clients; difficulties with internal and external communications; and lack of structural supports. Five policy/procedure themes emerged: program and service delivery changes; finance and administrative changes; safety protocols; advocacy for resources and community engagement; and changes to paid and volunteer staffing. The first wave of COVID-19 had a significant impact on the Manitoba charitable food sector. Food banks re-configured programs to meet client needs amid shifting public health directives, with diminished resources, rising demand, and insufficient government support. Despite the resiliency of community food organizations during the pandemic, the status quo with respect to addressing food insecurity is inefficient and inadequate.
Training of future teachers about educational technologies of vocational training
Authors: Kamalov Murat , Saipov Amangeldi , Kamalov Yusubali 
Published: October 2022

This study aimed at investigating the education of future teachers about the educational technologies of vocational education, and it was designed according to this purpose. In this context, it was aimed to conduct a study with the teachers of the future. The research was created and implemented in the 2021–2022 spring academic year. A total of 172 pre-service teachers voluntarily participated in the research. In the research, vocational education technologies were given with the help of online technology in the form of a 2-week online training to the group participating in the study. In order to collect data in the study, the ‘Vocational Education and Technology’ data collection tool, which was developed by the researchers and whose validity and reliability were obtained, was used. The data collection tool used in the research was delivered to the people participating in the research with the Google survey method and collected. The analysis of the data was made by using the Statistical Package for the Social Sciences programme, frequency analysis and t-test; the results are added to the research in the presence of tables. As a result of the research, it is seen that the teachers of the future will prefer technology for vocational education and use it in their professional life to achieve positive results.

Keywords: Teachers of the future, vocational education, online and distance education, technology;