bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of 0.01% low dose atropine and its correlation with various factors in myopia control in the Indian population
Authors: Chaurasia Shweta , Negi Seema , Kumar Ashok , Raj Srishti , Kaushik Sushmita , Optom Rahul Khanna M. , Kishore Pranav , Dogra Mangat Ram 
Published: May 2022

AbstractWe aimed to evaluate the efficacy and safety of low-dose atropine compared to placebo in the Indian population and also to study the impact of various modifiable and non-modifiable factors on myopia progression (MP) and drug efficacy (DE). It was a single-centre prospective placebo-controlled interventional study. 43 participants aged 6–16 years with progressive myopia received 0.01% atropine in the right eyes (treatment) and placebo in the left eyes (control) for 1-year. The main outcome measures were annual MP and axial length elongation (ALE) in treatment and control eyes and their percentage difference between two eyes (drug efficacy). Secondary outcome measures were the occurrence of any adverse events and the correlation of MP, ALE, and DE with various factors. 40 participants (80 eyes) completed the follow-up. After 1-year, MP was 0.25 D (IQR 0.13–0.44) and 0.69 D (IQR 0.50–1.0) (p < 0.001) in treatment and control respectively (63.89% reduction) with respective ALE of 0.14 mm (IQR 0.05–0.35) and 0.32 mm (IQR 0.19–0.46) (p < 0.001) (44.44% reduction). No adverse events were noted. Reduction in MP and ALE was statistically significant in all children irrespective of age-group, baseline MP, family history, screen-time, near and outdoor-time. The strongest determinants of annual MP were age (Treatment: r = − 0.418, p = 0.007; Control: r = − 0.452, p = 0.003) and baseline MP (Treatment: r = 0.64, p = 0.000; Control: r = 0.79, p = 0.000). Screen-time in control eyes was associated with greater ALE (r = 0.620, p = 0.042). DE was higher when outdoor time exceeded 2 h/day (p = 0.035) while the efficacy was lower with prolonged near activities (p = 0.03), baseline fast-progressors (p < 0.05) and history of parental myopia (p < 0.05). 0.01% atropine is effective and safe in retarding MP and ALE in Indian eyes.
Lymphocyte activation gene-3-associated protein networks are associated with HDL-cholesterol and mortality in the Trans-omics for Precision Medicine program
Authors: Manichaikul Ani , Lin Honghuang , Kang Chansuk , Yang Chaojie , Rich Stephen S. , Taylor Kent D. , Guo Xiuqing , Rotter Jerome I. , Craig Johnson W. , Cornell Elaine , Tracy Russell P. , Peter Durda J. , Liu Yongmei , Vasan Ramachandran S. , Adrienne Cupples L. , Gerszten Robert E. , Clish Clary B. , Jain Deepti , Conomos Matthew P. , Blackwell Thomas , Papanicolaou George J. , Rodriguez Annabelle 
Published: May 2022

AbstractDeficiency of the immune checkpoint lymphocyte activation gene-3 (LAG3) protein is significantly associated with both elevated HDL-cholesterol (HDL-C) and myocardial infarction risk. We determined the association of genetic variants within ±500 kb of LAG3 with plasma LAG3 and defined LAG3-associated plasma proteins with HDL-C and clinical outcomes. Whole genome sequencing and plasma proteomics were obtained from the Multi-Ethnic Study of Atherosclerosis (MESA) and the Framingham Heart Study (FHS) cohorts as part of the Trans-Omics for Precision Medicine program. In situ Hi-C chromatin capture was performed in EBV-transformed cell lines isolated from four MESA participants. Genetic association analyses were performed in MESA using multivariate regression models, with validation in FHS. A LAG3-associated protein network was tested for association with HDL-C, coronary heart disease, and all-cause mortality. We identify an association between the LAG3 rs3782735 variant and plasma LAG3 protein. Proteomics analysis reveals 183 proteins significantly associated with LAG3 with four proteins associated with HDL-C. Four proteins discovered for association with all-cause mortality in FHS shows nominal associations in MESA. Chromatin capture analysis reveals significant cis interactions between LAG3 and C1S, LRIG3, TNFRSF1A, and trans interactions between LAG3 and B2M. A LAG3-associated protein network has significant associations with HDL-C and mortality.
Statistical parametrization of cell cytoskeleton reveals lung cancer cytoskeletal phenotype with partial EMT signature
Authors: Basu Arkaprabha , Paul Manash K. , Alioscha-Perez Mitchel , Grosberg Anna , Sahli Hichem , Dubinett Steven M. , Weiss Shimon 
Published: May 2022

AbstractEpithelial–mesenchymal Transition (EMT) is a multi-step process that involves cytoskeletal rearrangement. Here, developing and using an image quantification tool, Statistical Parametrization of Cell Cytoskeleton (SPOCC), we have identified an intermediate EMT state with a specific cytoskeletal signature. We have been able to partition EMT into two steps: (1) initial formation of transverse arcs and dorsal stress fibers and (2) their subsequent conversion to ventral stress fibers with a concurrent alignment of fibers. Using the Orientational Order Parameter (OOP) as a figure of merit, we have been able to track EMT progression in live cells as well as characterize and quantify their cytoskeletal response to drugs. SPOCC has improved throughput and is non-destructive, making it a viable candidate for studying a broad range of biological processes. Further, owing to the increased stiffness (and by inference invasiveness) of the intermediate EMT phenotype compared to mesenchymal cells, our work can be instrumental in aiding the search for future treatment strategies that combat metastasis by specifically targeting the fiber alignment process.
Sense of self impacts spatial navigation and hexadirectional coding in human entorhinal cortex
Authors: Moon Hyuk-June , Gauthier Baptiste , Park Hyeong-Dong , Faivre Nathan , Blanke Olaf 
Published: May 2022

AbstractGrid cells in entorhinal cortex (EC) encode an individual’s location in space and rely on environmental cues and self-motion cues derived from the individual’s body. Body-derived signals are also primary signals for the sense of self and based on integrated sensorimotor signals (proprioceptive, tactile, visual, motor) that have been shown to enhance self-centered processing. However, it is currently unknown whether such sensorimotor signals that modulate self-centered processing impact grid cells and spatial navigation. Integrating the online manipulation of bodily signals, to modulate self-centered processing, with a spatial navigation task and an fMRI measure to detect grid cell-like representation (GCLR) in humans, we report improved performance in spatial navigation and decreased GCLR in EC. This decrease in entorhinal GCLR was associated with an increase in retrosplenial cortex activity, which was correlated with participants’ navigation performance. These data link self-centered processes during spatial navigation to entorhinal and retrosplenial activity and highlight the role of different bodily factors at play when navigating in VR.
An organic-Ru2+ cluster-initiated dendritic faced metallo-octahedron and its unpredictable photoactivity
Authors: Jiang Zhiyuan , Wu Tun , Li Yiming , Wang Jun , Chen Mingzhao , Su PeiYang , Zhang Zhe , Xie Ting-Zheng , Wang Pingshan 
Published: May 2022

A novel 3D metal-organic ligand and Zn2+ can give rise to the dendritic-faced metallo-octahedron. Remarkably, octahedron 6 displayed unexpected photosensitization ability which could produce singlet oxygen (1O2) under white light irradiation.
Startklar für die digitale Gesundheitswelt
Authors: Streber René , Diefenbach Karolin , Peters Stefan 
Published: May 2022

ZusammenfassungDie Digitalisierung hält zunehmend Einzug in das Gesundheitswesen und
bringt vielerlei neue Leistungen und Gesundheitsangebote sowie Begrifflichkeiten
mit sich. Gleichzeitig besteht großer Handlungsbedarf zur
Förderung der digitalen Gesundheitskompetenz der
Bevölkerung.Der Deutsche Verband für Gesundheitssport und Sporttherapie e.V. erhielt
von der DAK-Gesundheit den Auftrag zur Konzeption, Realisierung und Evaluation
einer Maßnahme zur Förderung der digitalen Gesundheitskompetenz.
Insbesondere sollten Personen im mittleren bis hohen Erwachsenenalter mit einer
niedrigen digitalen Gesundheitskompetenz adressiert werden. Für die
Rekrutierung wurden seitens der DAK-Gesundheit analoge und digitale
Kommunikationskanäle genutzt.Zur Förderung der digitalen Gesundheitskompetenz wurde ein
60-minütiger Online-Vortrag mit folgenden Themen entwickelt:
Gesundheitswebseiten, Qualitätssiegel und Qualitätskriterien,
Online Video-Sprechstunde, Elektronisches Rezept, App-Angebote für
Serviceleistungen, digitale Angebote in den Bereichen Prävention und
Gesundheitsförderung, Digitale Gesundheitsanwendungen (DiGAs) und
digitale Angebote zur Fortbildung im Bereich der häuslichen Pflege.Zwischen September 2021 und Dezember 2021 wurden acht Online-Vorträge
realisiert, an denen 901 Personen teilnahmen. Die Evaluation basiert auf den
Angaben von n=361 (40% der Teilnehmenden). 90% davon
haben dem Vortrag eine Gesamtbewertung von „gut“ oder
„sehr gut“ gegeben. Auch die weiteren Bewertungen deuten auf
eine hohe Zufriedenheit der Befragten mit dem Angebot hin.Die vorliegenden Befragungsergebnisse und die vom GKV-Spitzenverband benannten
Qualitätsmerkmale können perspektivisch einer Erweiterung des
DVGS-Leistungsspektrums zur Förderung der digitalen Gesundheitskompetenz
dienen.
Do Changes in Body Shape Due to Pregnancy Lead to Cosmetic Surgery? A
Cross-Sectional Study
Authors: Ulubasoglu Hasan , Bakay Kadir , Guven Davut , Ak Sertac , Yagmur Caglayan , Hatirnaz Safak , Sparic Radmila , Tinelli Andrea 
Published: May 2022

Abstract
Objective Pregnants and puerperas show different perceptions of their body
image and appearance, so authors investigated their perceptions related to
pregnancy and puerperium, evaluating their views on cosmetic surgery, by a
cross-sectional study.
Materials and Methods 5-item questionnaires were administrated to women at
first pregnancy and puerperas. Patients were submitted also to Beck Anxiety
Inventory (BAI), Beck Depression Inventory (BDI) and Body Image Inventory (BII)
analysis, indicating the level of anxiety, depression and body dissatisfaction
for somatic changes during pregnancy and after childbirth.
Results 186 healthy women, aged between 25–35 years, equally
divided in pregnancy and puerperium, were compared in terms of body image, with
no significant difference between groups. Analyzing the item “cosmetic
surgery is required after all pregnancies”, there was a significant
difference in puerperas and the item “cosmetic surgery is necessary for
postpartum” was the principal. The comparison of BII, BDI, BAI values
between pregnants and puerperas showed a significant difference between groups
(p<0.00), with higher scores in postpartum patients.
Conclusion Body shape and physical dissatisfaction during pregnancy is
linked with increased risk of depression in pregnancy and puerperium, pushing
women to opt for cosmetic surgery, especially in puerperium.
Einsatzplanung mit TECC - Tactical Emergency Casualty Care bei prinzipieller Amoklage
Authors: Wanger Anke , Faltlhauser Martin 
Published: May 2022

ZusammenfassungAm 17.02.2021 wurde in der Nacht im Briefzentrum des Flughafens München eine Paketbombe entdeckt; in den beiden Tagen zuvor waren bereits 2 ähnliche Bomben an ihren Zielen bei Firmen der Nahrungsmittelindustrie detoniert. In der interdisziplinären Zusammenarbeit von Feuerwehr, Polizei und Rettungsdienstes kamen diverse Aspekte der TECC (Tactical Emergency Casualty Care) zum Tragen, die in diesem Fallbericht näher beleuchtet werden.
A Selenenium-Bridged 10-Boratriptycene Lewis Acid
Authors: Chardon Aurélien , Berionni Guillaume , Osi Arnaud , Tumanov Nikolay , Wouters Johan 
Published: May 2022

AbstractA non-planar triarylborane and a new member of the boratriptycene family bearing a selenium atom in bridgehead position of triptycene scaffold was generated and isolated as a boron-‘ate’ complex paired with a weakly coordinating anion. With similar electronegativity while possessing longer atom radius with respect to sulfur, the introduction a selenium atom, in the form of a selenenium moiety, at the bridgehead of a triptycene scaffold allows a very precise modification of the pyramidalization of the boron atom environment. Experimental and computational evaluation of the Lewis acidity of this new boratriptycene derivative gave qualitative information on how a modification of the pyramidalization of the boron environment affects alone Lewis acidity parameters of such pyramidal triarylborane.
Is the Size of Insulinoma Predictive for its Endocrine Behavior?
An Endoscopic Ultrasound Study
Authors: Adelmeyer Jan , Göbel Franziska , Kann Peter Herbert 
Published: May 2022

Abstract
Objective Insulinoma is a rare tumor of the pancreas that can lead to
spontaneous hypoglycemia due to excessive insulin secretion. Seventy-two-hour
fast is the gold standard for finding the correct diagnosis. Endoscopic
ultrasound (EUS) is an established examination method to identify the
suspicious lesion. Previous studies correlate the measured size of insulinoma
and their endocrine behavior. This study was designed to find a relation between
these variables.
Methods We took the data of patients who had a histologically confirmed
insulinoma after receiving an endoscopic ultrasound in our department. Size and
echogenicity were correlated with the endpoint of the 72-hour fast and hormone
levels.
Results A total of 45 patients were identified. Most insulinomas were
small with a volume of<2 cm3 (median 1.15 cm3).
There was no correlation between the duration of fasting, hormone levels, and
the size of the insulinoma. In addition, in a subgroup analysis, no connection
could be established between the size of the insulinoma and the amount of
insulin released after oral glucose exposure. We found that homogeneous tumors
were significantly smaller and had a lower Ki-67 index. Furthermore, there was a
tendency towards a shorter duration for the 72-hour fast for the small
tumors.
Discussion This data suggests that the measured size of insulinoma by EUS
is not related to the time until termination of the 72-hour fast and measured
hormone levels. The echogenicity seems more important, showing that homogenous
tumors are an indicator of a higher differentiation, which can result in a
shorter duration of the fasting period. The differences in the secretion
behavior of the insulinomas could complicate the correlation of size and the
72-hour fast period.
Effects of Training and Taper on Neuromuscular Fatigue Profile on
100-m Swimming Performance
Authors: Ribeiro Felipe Alves , de Carvalho Carlos Dellavechia , Andreossi Júlia Causin , Miranda Douglas Rodrigues Messias , Papoti Marcelo 
Published: May 2022

AbstractThis study aimed to investigate the effects of 6-week specific preparatory period
and 2-week taper period on neuromuscular fatigue profile in 100-m front crawl
swimming performance. Seventeen competitive-level young-adult swimmers performed
a 100-m swimming performance at baseline and after 6-week specific preparatory
followed by 2-week taper periods. Neuromuscular fatigue profile was assessed
through percutaneous electrical stimuli on the femoral nerve during a maximal
voluntary contraction performed before and immediately after each 100-m maximal
effort. Performance improved (p=0.001) 2.24 and 3.06% after
specific and taper, respectively. Potentiated peak force at post-effort
condition decreased (p<0.001) 16.26% at baseline, 11.70%
at specific, and 12.86% at taper period. Maximal voluntary contraction
force also decreased (p<0.001) at post-effort condition by about 6.77
and 9.33% at baseline and specific period, respectively. Both variables
did not present significant differences between times. No condition or time
effects were observed to superimposed peak force and voluntary activation, both
related to central fatigue. In conclusion, neuromuscular fatigue during 100-m
swimming performance was exclusively developed by peripheral mechanisms
regardless of the training period, and 2-week taper was able to prevent
decreases in maximal voluntary contraction induced by 100-m maximal effort.
Attention Effects on Distortion-Product Otoacoustic Emissions with Contralateral Speech Stimuli
Authors: Timpe-Syverson Genaya Kae , Decker T. Newell 
Published: May 2022

AbstractThis study investigated the effect of selective attention on the distortion-product otoacoustic emission (DPOAE) level through the use of environmentally meaningful, contralateral auditory stimuli. Four different conditions were used for measurement: quiet, contralateral noise, contralateral speech (unattended), and contralateral speech (attended). A statistically significant suppression effect for both the noise and speech conditions was found. However, there was no support for an auditory selective attention effect on the distortion-product amplitude.
Abbreviations: ABR = auditory brainstem response, ANOVA = analysis of variance, DPOAEs = distortion-product otoacoustic emissions, IHC = inner hair cell, MES = medial efferent system, OAEs = otoacoustic emissions, OCB = olivochlear bundle, OHC = outer hair cell, SOAEs = spontaneous otoacoustic emissions, TEOAEs = transient evoked otoacoustic emissions
Otoacoustic Emissions in Normal-Cycling Females
Authors: Yellin M. Wende , Stillman Robert D. 
Published: May 2022

AbstractThe purpose of this study was to determine if the menstrual cycle influences the amplitude of transient (TEOAEs) and distortion-product (DPOAEs) otoacoustic emissions. Thirteen normal-hearing, normal-cycling females were monitored weekly for 12 weeks. TEOAE and DPOAE amplitudes were analyzed to determine if amplitude changes could be detected and correlated to phases of the menstrual cycle. No systematic amplitude changes were observed, demonstrating that evoked OAEs are unaffected by physiologic changes associated with the menstrual cycle.
Abbreviations: ABR = auditory brainstem response, DPOAEs = distortion product otoacoustic emissions, OAEs = otoacoustic emissions, RMANOVA = repeated measures analysis of variance, SOAEs = spontaneous otoacoustic emissions, TEOAEs = transient evoked otoacoustic emissions
Non-thermal plasma application improves germination, establishment and productivity of Gatton panic grass (
Authors: Pérez-Pizá María Cecilia , Clausen Liliana , Cejas Ezequiel , Ferreyra Matías , Chamorro-Garcés Juan Camilo , Fina Brenda , Zilli Carla , Vallecorsa Pablo , Prevosto Leandro , Balestrasse Karina 
Published: May 2022

Megathyrsus maximus (Gatton panic) is a tropical grass highly valued both for its use as forage and for its biofuel potential. A major constraint in establishing pastures of this cultivar is the low viability and germination of seeds and the poor initial seedling establishment. We used non-thermal plasma (NTP, partially ionised gas) as a novel technology to treat seeds of this grass, aiming to improve their quality (i.e. germination traits). We also followed the performance of seedlings grown from NTP-treated seeds under field conditions by assessing seedling establishment, biomass production and forage quality during the first regrowth period, which is the critical period for pasture establishment. Two NTP treatments were performed through dielectric barrier discharges employing N2 as carrier gas. Non-treated seeds served as the control. Results showed that the viability of NTP-treated seeds was, on average, 1.5-fold higher than the control, and that germination energy and germination percentage of treated seeds was superior to the control by 2.1-fold and 2.2-fold, respectively. A field experiment showed that seedling establishment parameters (dynamics of cumulative emergence, emergence coefficient, and weighted average emergence rate) and pasture early productivity (represented by shoot dry matter) were enhanced by NTP treatment (phenolic sheet–polyester film barrier and 3 min exposure), showing 1.4–2.6-fold higher values than the control, confirming the results of the laboratory assays. Although NTP markedly increased the shoot dry matter production of the pasture, which was related to higher tiller population density and greater tiller weight, it did not affect the forage quality of the plants grown in the field. We conclude that NTP technology is suitable to improve seed germination of Gatton panic, in turn leading to improvements in seedling establishment and biomass production under field conditions without compromising forage quality.
Species richness response to human pressure hides important assemblage transformations
Authors: Cazalis Victor 
Published: May 2022

Significance
Human activities are causing biodiversity loss, but there is still strong debate on their effect on species richness. Here, I propose a unification of five trajectories of species richness response to increasing human pressure under the “replace then remove framework.” It consists in a first phase of assemblage transformation (with the replacement of “loser” by “winner” species), often followed by a second phase of steep decline in species richness (with the decline of many winner species) when human pressure exceeds a certain threshold. The empirical results presented in this study provide an outstanding illustration of assemblage transformations that may cause biotic homogenization, demonstrating how habitat specialist, endemic, sensitive, and threatened species are replaced by others with increasing human pressure.
Revisiting the recombinant history of HIV-1 group M with dynamic network community detection
Authors: Olabode Abayomi S. , Ng Garway T. , Wade Kaitlyn E. , Salnikov Mikhail , Grant Heather E. , Dick David W. , Poon Art F. Y. 
Published: May 2022

Significance
Recombination is a major mechanism through which HIV type 1 (HIV-1) maintains genetic diversity and interferes with viral eradication efforts. There is growing evidence demonstrating a recombinant origin of primate lentiviruses including HIV-1 group M (HIV-1/M). Inferring the extent of recombination across the entire HIV-1/M genome is of great importance as it provides deeper insights into the origin, dynamics, and evolution of the global pandemic. Here we propose an alternative method that can reconstruct the extent of genome-wide recombination in HIV-1, uncover reticulate patterns, and serve as a framework for HIV-1 classification. Our method provides an alternative approach for understanding the roles of virus recombination in the early evolutionary history of zoonosis for other emerging viruses.