bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of heating on disposal point of main edible oils available in Iran market
Authors: Mohammadian Fazli Mehran , Zanganeh Hamid , Hassanzadazar Hassan 
Published: August 2022

AbstractDeep frying is the most common method used for food preparation worldwide, which can lead to several chemical changes in used fat or oil in frying process including oxidation and polymerization. This study aimed to determine the effect of heating and different storage conditions on the disposal point of four types of the most common edible oils available in the Iranian market without and with the presence of food in terms of acid value (AV) and total polar compounds (TPC). AV and TPC of three types of marketed sunflower oil (especially for frying, cooking, solid vegetable) and ghee heated at 110, 150, 180, and 200°C with a portable oil meter DOM‐24 (ATAGO, Japan) were determined. They were measured without the presence of food at four different temperatures and four different times in five storage conditions and with the presence of frying food (chicken and potatoes) at 110°C for 20 min in three replicates. The results showed that the AV and TPC contents in the case of ghee were above national and international standards without the presence of food. Also, in the process of frying chicken and potato, the reusability of all the studied oils was not possible for the second time and reached the disposal point. The increase in the rate of AV and TPC of oils was: ghee (Kermanshahi oil) > liquid cooking oil > frying oil ≥ solid vegetable oil.
The Phenazine Scaffold Used as Cytotoxic Pharmacophore Applied in Bactericidal, Antiparasitic and Antitumor Agents
Authors: Miksa Beata 
Published: August 2022

AbstractPhenazine derivatives are important bactericidal antibiotics and antiparasitic compounds which can be used in synergistic combinations with anticancer drugs in chemotherapy treatments. The development of synthetic phenazines with anticancer activity improves the effectiveness of chemotherapy. Chemical variations introduced at the phenazine core which is known as a chromophore with fluorescent properties provide advanced theranostic agents useful in optical bioimaging techniques and photodynamic anticancer therapy. This review summarizes the field of structural modifications of phenazine derivatives which have been tested against different parasitic and bacterial infections. The report highlights advances in design and biological evaluations of phenazines as anticancer drugs for the development of new chemotherapeutic as well as bio‐imaging reagents.
Past, present, and possible future policies on plastic use in the United States, particularly microplastics and nanoplastics: A review
Authors: Sorensen Rachel M. , Kanwar Rameshwar S. , Jovanovi Boris 
Published: August 2022

Abstract
As the levels of plastic use in global society have increased, it has become crucial to regulate plastics of all sizes including both microplastics (MPs) and nanoplastics (NPs). Here, the published literature on the current laws passed by the US Congress and regulations developed by various federal agencies such as the US Environmental Protection Agency and the US Food and Drug Administration (FDA) that could be used to regulate MPs and NPs have been reviewed and analyzed. Statutes such as the Clean Water Act, the Safe Drinking Water Act, the Toxic Substances Control Act (TSCA), the Resource Conservation and Recovery Act, and the Clean Air Act can all be used to address plastic pollution. These statutes have not been invoked for MP and NP waste in water or air. The Federal Food, Drug, and Cosmetic Act provides guidance on how the FDA should evaluate plastics use in food, food packaging, cosmetics, drug packaging, and medical devices. The FDA has recommended that acceptable levels of ingestible contaminant from recycled plastic are less than 1.5 µg/person/day, which is 476 000 times less than the possible ingested daily dose. Plastic regulation is present at the state level. States have banned plastic bags, and several cities have banned plastic straws. California is the only state beginning to focus on monitoring MPs in drinking water. The future of MP regulation in the USA should use TSCA to test the safety of plastics. The other statutes need to include MPs in their definitions. For the FDA, MPs should be redefined as contaminants—allowing tolerances to be set for MPs in food and beverages. Through minor changes in how MPs are classified, it is possible to begin to use the current statutes to understand and begin to minimize the possible effects of MPs on human health and the environment. Integr Environ Assess Manag 2023;19:474–488. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Diabetes is associated with high risk of severe adverse events during chemotherapy for cancer patients: A single‐center study
Authors: Mailliez Aurélie , Ternynck Camille , Duhamel Alain , Mailliez Audrey , Ploquin Anne , Desauw Christophe , Lemaitre Madleen , Bertrand Nicolas , Vambergue Anne , Turpin Anthony 
Published: August 2022

AbstractDiabetes mellitus (DM) is a common comorbidity among cancer patients, but its impact on chemotherapy tolerance has not been widely studied. We aimed to compare the occurrence of severe grade 3/4 adverse events (G3/4 AEs) within 90 days of starting chemotherapy between patients with and without diabetes. We conducted a retrospective single‐center study in Lille University Hospital Oncology Department, France. Patients who received the first cycle of chemotherapy for gastrointestinal, gynecological or cancer of unknown primary source between 1 May 2013 and 1 May 2016, were included. Overall, 609 patients were enrolled: 490 patients without diabetes (80.5%) and 119 patients with diabetes (19.5%). Within 90 days of starting chemotherapy, patients with diabetes had a significantly higher occurrence of AEs G3/4 compared to those with no diabetes (multivariate odds ratio [OR]: 1.57 [1.02‐2.42], P = .04). More frequent G3/4 AEs in patients with diabetes were infection (26%), hematological disorders (13%), endocrine disorders (13%) and deterioration of the general condition (13%). In the year following the beginning of chemotherapy, patients with diabetes were twice as likely to be hospitalized as those without diabetes (univariate OR: 2.1 [1.40‐3.15], P = .0003). After multivariate adjustment, diabetes was no longer significantly associated with the risk of hospitalization (P = .051). There were no differences between patients with and without diabetes regarding dose reduction and chemotherapy treatment delays (P = .61 and P = .30, respectively). Our study suggests the need for better consideration of DM in the personalized care plan to improve chemotherapy tolerance and quality of life of patients with DM.
Chiral Ligands for Au(I), Au(III), and Au(I)/Au(III) Redox Catalysis
Authors: Mishra Sampoorna , Urvashi  , Patil Nitin T. 
Published: August 2022

AbstractGold catalysis has emerged as an efficient tool for the selective functionalisation of C−C multiple bonds. Despite significant progress in this field, the potential of asymmetric gold catalysis has not been fully explored to date. A historical retrospect on the progress in this area reveals that enantioselective gold catalysis is based on three pillars: Au(I) catalysis, Au(III) catalysis, and Au(I)/Au(III) redox catalysis. Irrespective of the mode of catalysis being operative, the design of new ligands is crucial for the development of gold‐catalysed organic transformations. This minireview summarizes the progress made in the development of ligand design for enantioselective Au(I) catalysis, Au(III) catalysis, and Au(I)/Au(III) redox catalysis focusing on the ligands which were specially designed for gold catalysis.
Effect of vaginal scarring on the recovery of surgical repair of obstetric fistula in Northern Ethiopia
Authors: Ambese Tesfay Yohannes , Gebre Hagazi , Berhe Awtachew , Fisseha Girmatsion , Gufue Zenawi Hagos , Hailu Nigus Alemu , Ebrahim Mohamedawel Mohamednigus , Abraha Hiluf Ebuy 
Published: August 2022

AbstractObjectiveTo determine the effect of vaginal scarring on the recovery from surgical repair of obstetric fistula in Northern Ethiopia from 2015 to 2020.MethodsA hospital‐based retrospective cohort study was conducted among 224 women who had obstetric fistula repair surgery in Northern Ethiopia from March 1 to March 31, 2020. Cox proportional hazards regression model was used to determine the adjusted predictors of recovery for each main baseline predictor variable, using 95% confidence interval (CI) and P < 0.05 to declare statistical significance.ResultsThe overall recovery rate was 57 of 1000 women (43 of 1000 and 73 of 1000 for women with and without vaginal scar, respectively), with an overall median time to recovery from obstetric fistula repair surgery of 15 days. Vaginal scarring (adjusted hazard ratio [aHR], 1.58 [95% CI, 1.13–2.21]), age of the patient (aHR, 4.05 [95% CI, 1.56–10.5]), mode of delivery (aHR, 2.14 [95% CI, 1.31–3.49]), place of delivery (aHR, 1.91 [95% CI, 1.17–3.12]), prior repair (aHR, 1.90 [95% CI, 1.08–3.35]), and duration of catheterization (aHR, 12.91 [95% CI, 7.21–23.13]) were independent predictors of recovery.ConclusionsIn the present study, we found that women who had no vaginal scar, age older than 30 years, facility and spontaneous vaginal delivery, first attempt repair, and shorter duration of catheterization had a shorter recover time.
On the timing of relevant weather conditions in agriculture
Authors: Li Zhiyun , Ortiz‐Bobea Ariel 
Published: August 2022

AbstractA growing literature is analyzing the effects of weather on agricultural outcomes. In these studies, constructing weather variables requires researchers to define a “season,” a period over which weather conditions are considered relevant to the outcome. We explore the consequences of assuming an incorrect season in such analyses. We show in simulations that imposing an incorrect season introduces nonclassical measurement error in weather regressors, bias in unknown directions. We propose an approach to recover the “true” underlying season and apply it to a US state‐level panel of agricultural Total Factor Productivity. We find that accounting for seasonality can lead to substantially different estimates.
Adolescent homelessness: Evaluating victimization risk based on LGBT identity and sleeping location
Authors: Flatley Claire A. , Hatchimonji Danielle R. , Treglia Dan , Cutuli J. J. 
Published: August 2022

AbstractBackgroundTeen homelessness confers risk for victimization experiences, and teens that identify as lesbian, gay, bisexual, or transgender (LGBT) are at an even greater risk of experiencing victimization and homelessness.MethodsUsing the 2019 Youth Risk Behavior Surveillance System, we evaluated the association of experiencing homelessness with physical and sexual victimization and we examined whether LGBT identification moderated this relationship. We also evaluated if the odds of experiencing sexual and physical victimization differed depending on the reported sleeping location.ResultsStudents who reported homelessness had increased odds of having experienced physical and sexual victimization. LGBT identity was related to increased risk for physical and sexual victimization; however, LGBT identity did not moderate the relationship between homelessness and victimization. Considering nighttime sleeping arrangement, students who reported having no usual place to stay had the highest odds of experiencing sexual or physical victimization, followed by car, park, campground, hotels/motels, emergency housing, and doubled‐up with family or friends. Notably, all homeless sleeping locations were associated with increased odds of experiencing victimization relative to sleeping at a parent or guardian's home.ConclusionsOur findings confirm links between teen homelessness and sexual and physical victimization, as well as increased risk for victimization experienced by LGBT youth. Special considerations should be made when developing and implementing interventions for teens experiencing homelessness and teens who identify as LGBT.
Management of Primary Hyperparathyroidism
Authors: Bilezikian John P. , Silverberg Shonni J. , Bandeira Francisco , Cetani Filomena , Chandran Manju , Cusano Natalie E. , Ebeling Peter R. , Formenti Anna Maria , Frost Morten , Gosnell Jessica , Lewiecki E. Michael , Singer Frederick R. , Gittoes Neil , Khan Aliya A. , Marcocci Claudio , Rejnmark Lars , Ye Zhikang , Guyatt Gordon , Potts John T. 
Published: August 2022

ABSTRACT
Since the last international guidelines were published in 2014 on the evaluation and management of primary hyperparathyroidism (PHPT), new information has become available with regard to evaluation, diagnosis, epidemiology, genetics, classical and nonclassical manifestations, surgical and nonsurgical approaches, and natural history. To provide the most current summary of these developments, an international group, consisting of over 50 experts in these various aspects of PHPT, was convened. This paper provides the results of the task force that was assigned to review the information on the management of PHPT. For this task force on the management of PHPT, two questions were the subject of systematic reviews using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) methodology. The full report addressing surgical and nonsurgical management of PHPT, utilizing the GRADE methodology, is published separately in this series. In this report, we summarize the results of that methodological review and expand them to encompass a much larger body of new knowledge that did not specifically fit the criteria of the GRADE methodology. Together, both the systematic and narrative reviews of the literature, summarized in this paper, give the most complete information available to date. A panel of experts then considered the last set of international guidelines in light of the newer data and assessed the need for their revision. This report provides the evidentiary background to the guidelines report. In that report, evidence from all task forces is synthesized into a summary statement and revised guidelines for the evaluation and management of PHPT. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Evaluation and Management of Hypoparathyroidism Summary Statement and Guidelines from the Second International Workshop
Authors: Khan Aliya A. , Bilezikian John P. , Brandi Maria Luisa , Clarke Bart L. , Gittoes Neil J. , Pasieka Janice L. , Rejnmark Lars , Shoback Dolores M. , Potts John T. , Guyatt Gordon H. , Mannstadt Michael 
Published: August 2022

ABSTRACT
This clinical practice guideline addresses the prevention, diagnosis, and management of hypoparathyroidism (HypoPT) and provides evidence-based recommendations. The HypoPT task forces included four teams with a total of 50 international experts including representatives from the sponsoring societies. A methodologist (GG) and his team supported the taskforces and conducted the systematic reviews. A formal process following the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology and the systematic reviews provided the structure for seven of the guideline recommendations. The task force used a less structured approach based on narrative reviews for 20 non-GRADEd recommendations. Clinicians may consider postsurgical HypoPT permanent if it persists for &gt;12 months after surgery. To predict which patients will not develop permanent postsurgical HypoPT, we recommend evaluating serum PTH within 12 to 24 hours post total thyroidectomy (strong recommendation, moderate quality evidence). PTH &gt; 10 pg/mL (1.05 pmol/L) virtually excludes long-term HypoPT. In individuals with nonsurgical HypoPT, genetic testing may be helpful in the presence of a positive family history of nonsurgical HypoPT, in the presence of syndromic features, or in individuals younger than 40 years. HypoPT can be associated with complications, including nephrocalcinosis, nephrolithiasis, renal insufficiency, cataracts, seizures, cardiac arrhythmias, ischemic heart disease, depression, and an increased risk of infection. Minimizing complications of HypoPT requires careful evaluation and close monitoring of laboratory indices. In patients with chronic HypoPT, the panel suggests conventional therapy with calcium and active vitamin D metabolites as first-line therapy (weak recommendation, low-quality evidence). When conventional therapy is deemed unsatisfactory, the panel considers the use of PTH. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
MALT1 reflects inflammatory cytokines, disease activity, and its chronological change could estimate treatment response to infliximab in Crohn's disease patients
Authors: Dong Xiaoxia , Chen Xiaoxiao , Ren Yuxiu 
Published: August 2022

AbstractBackgroundMucosa‐associated lymphoid tissue lymphoma translocation protein 1 (MALT1) mediates the immunity and inflammatory response in multiple ways to be intimately involved in the progression of autoimmune diseases. This study intended to explore the linkage of MALT1 with inflammation, disease activity, and its change with infliximab treatment response in Crohn's disease (CD) patients.MethodsMALT1 in peripheral blood mononuclear cell samples from 72 active CD patients (at baseline, 2 weeks [W2], W6, and W12 after infliximab treatment), 20 remissive CD patients (after enrollment), and 20 healthy controls (after enrollment) were detected by RT‐qPCR.ResultsMALT1 was highest in active CD patients, followed by remissive CD patients, and lowest in healthy controls (p < 0.001). MALT1 was positively linked with C‐reactive protein (p = 0.001), erythrocyte sedimentation rate (p = 0.014), clinical disease activity index (p = 0.003), tumor necrosis factor (TNF)‐α (p = 0.006), interleukin (IL)‐1β (p = 0.049), and IL‐17A (p = 0.004), but not other clinical characteristics (all p > 0.05) in active CD patients. After infliximab treatment, MALT1 was decreased from baseline to W12 in active CD patients (p < 0.001), especially in responders (p < 0.001), but not in nonresponders (p = 0.053). The reduction of MALT1 at W6 (p = 0.049) and W12 (p = 0.004) was associated with a good treatment response to infliximab in active CD patients. Moreover, the response rate or MALT1 at any time point was not different between active CD patients with and without TNFi history (all p > 0.05).ConclusionMALT1 reflects aggravated inflammation and disease activity. Meanwhile, the decrement of MALT1 from baseline to W12 could reflect infliximab treatment response in CD patients.
Strategies to shorten turnaround time in outpatient laboratory
Authors: Lee Seunghoo , Yoon Sangpil , Lee Woochang , Chun Sail , Min Won‐Ki 
Published: August 2022

AbstractBackgroundTurnaround time (TAT) is one of the most important indicators of laboratory quality. For the outpatient routine chemistry tests whose results are checked by clinicians on the same day, we set a quality goal that >90% of these samples should be reported within 60 min. As more than 20% of the samples failed to achieve this goal in 2020, we introduced an additional autoanalyzer and a real‐time monitoring system to improve this rate.MethodsAs the TAT of the pre‐analytical phase is the greatest contributor to TAT, we divided it into sampling, sample transport, and sample preparation times. An additional autoanalyzer was introduced, and its effect on TAT improvement was evaluated with the TAT data of June and July 2020. A real‐time monitoring system was introduced to sort delayed samples, and its effect was assessed with the TAT data of June and July 2021. TAT data from December 2019 to January 2020 were set as baseline controls.ResultsThe preparation time comprised the largest proportion of TAT. Although there was a slight decrease in overall TAT after the introduction of the above two strategies, the target TAT achievement rate increased significantly from 78.5% to 88.7% (p < 0.001).ConclusionsWe checked the cause of TAT prolongation and introduced new strategies to improve it. The addition of an autoanalyzer per se was not so effective but was better when combined with the real‐time monitoring system. Such strategies would increase the quality of the laboratory services.
Decreased serum interleukin‐41/Metrnl levels in patients with Graves' disease
Authors: Gong Luping , Huang Guoqing , Weng Linjie , Xu Jialu , Li Yan , Cui Wugeng , Li Mingcai 
Published: August 2022

AbstractBackgroundInterleukin (IL)‐41, also known as Metrnl, is a novel immunomodulatory cytokine, which is involved in the pathogenesis of many inflammatory and metabolic diseases, but its role in thyroid autoimmune diseases is not clear. The aim of this study was to evaluate the serum IL‐41 levels in patients with Graves' disease (GD) and its relationship with GD.MethodsThis study included a total of 49 GD patients and 47 age‐ and sex‐matched healthy individuals. All baseline data were obtained by physical examination. Free triiodothyronine 3 (FT3), free triiodothyronine 4 (FT4), thyroid‐stimulating hormone (TSH), anti‐thyroglobulin antibodies (TgAb), thyroid peroxidase antibody (TPOAb), and thyrotropin receptor antibody (TRAb) levels in plasma of GD patients were measured by chemiluminescence. The high‐sensitivity C‐reactive protein (CRP) and white blood cell count (WBC) were detected using automated biochemical analyzer. Serum IL‐41 levels were measured by enzyme‐linked immunosorbent assay.ResultsSerum IL‐41 levels in patients with GD were significantly lower than those in healthy controls (201.0 vs. 260.8 pg/mL, p < 0.05). There was a significant positive correlation between IL‐41 level and CRP (r = 0.2947, p = 0.0385) and WBC (r = 0.4104, p = 0.0034) in GD patients. CRP was positively correlated with TRAb (r = 0.2874, p = 0.0452) and TSH (r = 0.3651, p = 0.0099) levels in GD patients.ConclusionsThis study demonstrates that GD patients have decreased serum IL‐41 levels, and IL‐41 plays a potential role in abnormal immune response of GD patients.