bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevation of plasma phosphorylated tau181 during neurological illnesses affecting consciousness and kidney dysfunction
Authors: Thanapornsangsuth Poosanu , Ongphichetmetha Tatchaporn , Luechaipanit Watayuth , Hemachudha Pasin , Hemachudha Thiravat 
Published: September 2022

AbstractIntroductionPhosphorylated tau (p‐tau)181 has become a promising blood‐based Alzheimer's disease (AD) biomarker. We studied the agreement of plasma p‐tau181 and cerebrospinal fluid (CSF) markers in patients with alteration of consciousness (AOC).MethodsPlasma and CSF were simultaneously collected in participants presenting with AOC. Plasma p‐tau181 was measured using the single‐molecule array. CSF biomarkers were classified according to the amyloid/tau/neurodegeneration (AT[N]) framework.ResultsAmong participants enrolled, the median (interquartile range) age was 57 (28.5–75) years and 5.8% had AD. Plasma p‐tau181 yielded area under the curve of 0.85 and showed moderate correlation with CSF p‐tau181 (Rho = 0.42, P < .001). Using the historical cut‐point, many non‐AD participants had elevated plasma p‐tau181 resulting in a specificity of 0.57. Plasma p‐tau181 correlated with the glomerular filtration rate (Rho = –0.52, P < .001). Among A− participants with elevated plasma p‐tau181, 42% had kidney dysfunction.DiscussionPlasma p‐tau181 showed inadequate specificity in patients with AOC partially attributable to concomitant kidney dysfunction.
Negative caregiving and stress reactivity moderate the relation between early life stress and externalizing in adolescence
Authors: Buthmann Jessica , Miller Jonas G. , Chahal Rajpreet , Berens Anne , Gotlib Ian H. 
Published: September 2022

AbstractExposure to early life stress (ELS) is common and has been implicated in the development of psychopathology; importantly, however, many individuals who experience ELS do not develop emotional or behavioral difficulties. Prior research implicates stress exposure, negative caregiving behaviors, and patterns of physiological reactivity in predicting psychological well‐being; however, the precise factors that contribute to resilience versus vulnerability to the adverse effects of stress exposures are not well understood. In a longitudinal study of adolescents (N = 120) assessed at three timepoints approximately every 2 years beginning at the ages of 913 years, we examined the roles of autonomic reactivity to social stress (assessed through skin conductance during the Trier Social Stress Task) and negative caregiving behaviors as moderators of the association between exposure to ELS and internalizing and externalizing symptoms. We found that the relation between ELS and externalizing symptoms was moderated by both negative caregiving and autonomic reactivity, such that the relation between ELS and externalizing was positive at low levels of negative caregiving and at high levels of autonomic reactivity; interactions predicting internalizing symptoms were not statistically significant. These findings highlight the importance of considering physiological and environmental variables that might contribute to susceptibility or resilience to symptoms of psychopathology following exposure to ELS.
Enantioseparation of planar chiral ferrocenes on cellulose‐based chiral stationary phases: Benzoate versus carbamate pendant groups
Authors: Dallocchio Roberto , Dessì Alessandro , Sechi Barbara , Chankvetadze Bezhan , Jibuti Giorgi , Cossu Sergio , Mamane Victor , Peluso Paola 
Published: September 2022

AbstractIn this study, the enantioseparation of 14 planar chiral ferrocenes containing halogen atoms, and methyl, iodoethynyl, phenyl, and 2‐naphthyl groups, as substituents, was explored with a cellulose tris(4‐methylbenzoate) (CMB)‐based chiral column under multimodal elution conditions. n‐Hexane/2‐propanol (2‐PrOH) 95:5 v/v, pure methanol (MeOH), and MeOH/water 90:10 v/v were used as mobile phases (MPs). With CMB, baseline enantioseparations were achieved for nine analytes with separation factors (α) ranging from 1.24 to 1.77, whereas only three analytes could be enantioseparated with 1.14 ≤ α ≤ 1.51 on a cellulose tris(3,5‐dimethylphenylcarbamate) (CDMPC)‐based column, used as a reference for comparison, under the same elution conditions. Pendant group–dependent reversal of the enantiomer elution order was observed in several cases by changing CMB to CDMPC. The impact of analyte and chiral stationary phase (CSP) structure, and MP polarity on the enantioseparation, was evaluated. The two cellulose‐based CSPs featured by different pendant groups were also compared in terms of thermodynamics. For this purpose, enthalpy (ΔΔH°), entropy (ΔΔS°) and free energy (ΔΔG°) differences, isoenantioselective temperatures (Tiso), and enthalpy/entropy ratios (Q), associated with the enantioseparations, were derived from van ’t Hoff plots by using n‐hexane/2‐PrOH 95:5 v/v and methanol/water 90:10 v/v as MPs. With the aim to disclose the functions of the different substituents in mechanisms and noncovalent interactions underlying analyte–selector complex formation at molecular level, electrostatic potential (V) analysis and molecular dynamics simulations were used as computational techniques. On this basis, enantioseparations and related mechanisms were investigated by integrating theoretical and experimental data.
LiDAR‐based semi‐automated mapping of drumlins and mega‐scale glacial lineations of the Green Bay Lobe, Wisconsin, USA: Ice sheet beds as glaciotribological systems
Authors: Eyles Nick , Bukhari Syed , Sookhan Shane , Ruscica Phil , Paulen Roger 
Published: September 2022

AbstractA machine learning methodology for processing and visualizing high‐resolution LiDAR digital data is used to map drumlins and mega‐scale glacial lineations (MSGLs) on the bed of the Late Wisconsin Green Bay Lobe in Wisconsin, USA, which exhibited surge‐like behaviour during deglaciation. Previous work has shown that streamlined bedforms are the product of erosional streamlining of pre‐existing sediment. Analysis of bedform height and elongation ratio using curvature‐based relief separation (CBRS) andK‐means clustering of 32,003 bedforms reveals a continuum of six morphotypes ranging from drumlins, through “channeled” more elongated multi‐crested drumlins, to MSGLs. Further statistical analysis shows that morphotypes cluster into six types of streamlined surfaces (S1–S6) recording progressive elimination of an antecedent overridden topography to produce a smoother bed. Initial, relatively high‐relief drumlinized surfaces (S1, S2) occur around the slower‐flowing lateral flanks of the lobe, where a pre‐existing hummocky morainal topography was only partially modified by subglacial erosion. More streamlined surfaces (S3, S4) dominated by multi‐crested more elongate drumlins of reduced relief amplitude are transitional to flow sets of MSGL‐dominated surfaces (S5, S6) indicative of much faster‐flowing ice streaming along the lobe's axis. Estimates of basal drag based on roughness calculations for each surface type identify a 61% reduction in frictional retardation from poorly streamlined surfaces S1 and S2 to MSGL‐dominated surfaces S5 and S6, with a step‐like reduction between drumlins and channeled drumlins (S3, S4) possibly recording the rapid onset of fast flow. Subglacial streamlining is argued to be accomplished by a thin (<1 m) “third layer” of deforming subglacial debris between ice and its bed which functioned as an erodent layer. A thin (<3 m) till cap, formed by aggradation of deforming debris, rests unconformably on heterogeneous core sediments. Streamlined subglacial surfaces are comparable to the “functional” surfaces resulting from erosion by a “third layer” of wear debris in engineering tribological systems, and also by gouge on faults. Pleistocene ice sheets expanded over pre‐existing landsystems, pointing to the broader relevance of the methodology and findings reported here.
Application of Hermite wavelet method for heat transfer in a porous media
Authors: Vinod Y. , Raghunatha K. R. 
Published: September 2022

AbstractIn this article, the flow and heat transfer for non‐Newtonian viscoelastic fluid in an axisymmetric channel with a porous wall is investigated. Convective boundary conditions have been used in the problem formulation. We obtain coupled, highly nonlinear ordinary differential equations from the fundamental governing equations via appropriate similarity variables. The solution for velocity and temperature are computed by applying the Hermite wavelet method (HWM). The comparison between the results from the HWM, differential transform method, and numerical method are well in agreement which proves the capacity of HWM for solving such problems. The effects of Reynolds number and Prandtl number on the velocity and temperature are illustrated through graphs and tables for different values of an independent variable.
Assessment of the acute‐ and long‐term application of naloxone training on a simulated overdose response
Authors: Franko Thomas 
Published: September 2022

AbstractIntroductionPharmacist training on naloxone is often assessed within a year of initial instruction, however, the retention of the skills necessary in a naloxone rescue beyond this time frame has not been well established.ObjectiveThe aim of this study was to determine the acute‐ vs long‐term application of naloxone training on a simulated overdose response.MethodsPharmacy students in their first professional year (P1) were provided asynchronous training on naloxone information and use 2 days prior to a required skills lab. During the lab, students completed an overdose simulation with naloxone response. Students in their third professional year (P3) had a required skills lab focused on substance use disorders at the same time as the P1 lab. These students, who received the same training as the current P1's 2 years prior, completed the same overdose simulation with naloxone response during their scheduled lab time. A checklist from previously published work was used to evaluate student performance during each simulation. Results of the P1 and P3 simulations were compared.ResultsOne hundred percent of P1 students (n = 65) and 97% of P3 students (n = 65) consented to have their data used as part of the study. The median scores for the simulation were 82% (interquartile range [IQR] = 9) for the P1 students and 73% (IQR = 9) for the P3 students (p = 0.58). A significant difference between the groups existed for two items on the checklist: assess the scene is safe (P1 = 52%, P3 = 26%, p = 0.002), and determine if the patient is breathing (P1 = 18%, P3 = 34%, p = 0.04).ConclusionStudents who received initial instruction on naloxone use 2 years prior to a simulated naloxone rescue demonstrated similar results to those who received initial instruction 2 days prior to the same simulation.
Rapid detection of hepatitis B virus DNA level based on interval‐point data fusion of infrared spectra
Authors: Chen Jiaze , Ma Jinfang , Han Xueqin , Zhou Yongxin , Xie Baiheng , Huang Furong , Li Li , Li Yuanpeng 
Published: September 2022

AbstractHepatitis B is an infectious disease cause by the hepatitis B virus (HBV). In recent years, HBV‐DNA level clinically gets more attention for its detailed information than other serological markers. Unfortunately, common clinical method for HBV‐DNA level detection is limited for its hours consuming. This study combined infrared spectroscopy with machine learning to investigate the feasibility of near‐infrared (NIR) and mid‐infrared (MIR) spectra for rapid detection of HBV‐DNA level. Based on partial least squares‐discriminant analysis (PLS‐DA) modeling method, the optimal NIR and MIR models and traditional data fusion models were constructed, respectively. Considering inequal weight between interval and point data in machine learning, interval‐point data fusion method was used to compare with other traditional date fusion methods. The results of the study illustrate that interval‐point data fusion of NIR and MIR spectra combined with PLS‐DA modeling can provide a rapid method for HBV‐DNA level detection.
Quantitative analysis of tissue area of endoscopic ultrasound‐guided liver biopsy specimens using 19‐gauge fine‐needle biopsy needle in patients with diffuse liver disease: A single‐center retrospective study
Authors: Matsumoto Kotaro , Doi Shinpei , Watanabe Ayako , Katsukura Nobuhiro , Tsujikawa Takayuki , Takahashi Mikiko , Kikuchi Kentaro 
Published: September 2022

AbstractBackground/PurposeEndoscopic ultrasound‐guided liver biopsy (EUS‐LB) is a novel liver biopsy technique. We aimed to evaluate the efficacy and safety of EUS‐LB in comparison with percutaneous liver biopsy (PLB).MethodsThis retrospective study evaluated the safety and efficacy of EUS‐LB using a 19‐gauge fine needle biopsy (FNB) needle compared with PLB using a spring‐loaded 16‐gauge needle in patients with diffuse liver disease at our hospital from April 2017 to December 2020. The primary outcomes included the total hepatic tissue surface area and the total number of portal tracts. Secondary outcomes included the success and adverse event rates.ResultsTwenty patients each underwent EUS‐LB and PLB. There was no statistical difference in the sum of liver tissue surface area (22 mm2 vs 22.6 mm2, P = .910) and the total number of portal tracts (29 vs 25, P = .916). The success rate was 95% (19/20) for EUS‐LB and 100% (20/20) for PLB (P = 1). There were two adverse events in the PLB group but none in the EUS‐LB group (P = .487).ConclusionsEndoscopic ultrasound‐guided liver biopsy using FNB has an optimal tissue yield and success rate and is safe compared to PLB. Thus, EUS‐LB may be a new alternative to PLB.
Outcomes of neoadjuvant gemcitabine plus S‐1 and radiation therapy for borderline resectable pancreatic cancer
Authors: Yabushita Yasuhiro , Matsuyama Ryusei , Miyake Kentaro , Homma Yuki , Kumamoto Takafumi , Misumi Toshihiro , Hata Masaharu , Yamanaka Shoji , Fujii Satoshi , Endo Itaru 
Published: September 2022

AbstractBackgroundThe efficacy of multidisciplinary treatment, including neoadjuvant treatment, in borderline resectable pancreatic cancer (BRPC) remains unclear. We assessed the efficacy of neoadjuvant chemoradiotherapy with gemcitabine and tegafu/gimearcil/oteracil (S‐1) for BRPC.MethodsIn a single center, nonrandomized prospective study, neoadjuvant chemoradiotherapy (NACRT) with gemcitabine plus S‐1 was administered for BRPC (no. B090312028) in 122 patients enrolled between 2009 and 2015. Gemcitabine plus S‐1 comprised gemcitabine on days 8 and 15, and daily S‐1 on days 1‐14. After two courses of gemcitabine plus S‐1, 30 Gy radiotherapy was administered in 10 fractions with S‐1.ResultsEighty‐four and 38 patients had BR‐PV and BR‐A, respectively. No deaths occurred during NACRT. Ninety‐four patients (77%) underwent resection with curative intent. R0 resection was performed in 91% of resected cases. Patients who underwent post‐NACRT resection had better overall survival than did patients without resection (mean survival time [MST]: 24.7 vs 9.6 months, 5‐year‐survival rate (5 years): 30.3% vs 0%, P < .001). Adjuvant chemotherapy was administered in 73% of patients. MST and 5‐year survival rate of the patients treated with NACRT followed by resection and adjuvant chemotherapy were 29.6 months and 34.3%, respectively.ConclusionsNeoadjuvant chemoradiotherapy with gemcitabine and S‐1 can be safely administered in BRPC and may require adjuvant chemotherapy.Clinical Trial Registration NumberThis study was registered with the University Hospital Medical Information Network‐Clinical Trials Registry (UMIN‐CTR) UMIN000006782.
Psychological research and practice in former Yugoslavia and its successors
Authors: Pajić Dejan , Biro Mikloš 
Published: September 2022

AbstractThis paper presents a brief history of Yugoslav psychology and a review of the current state of psychological research and practice in the former Yugoslav countries. Bibliometric mapping was used to explore the knowledge domain and international visibility of psychological research in Bosnia and Herzegovina, Croatia, North Macedonia, Montenegro, Serbia, and Slovenia. Judging by the number of papers visible in Scopus, psychological research activity in these countries is similar to the other former communist countries. In a relative sense, it is even higher in Slovenia and Croatia. However, psychologists still rely heavily on national journals indexed in Scopus when publishing their papers. Regarding psychological practice, former Yugoslav countries are facing challenges that are more or less typical for all small countries in the global scientific and economic market. Keeping in mind all the obstacles and traumas in the past decades, it should be considered a success that psychology in the former Yugoslav countries is now a fully established profession and a recognized scientific discipline.
HIV and suicide risk across adolescence and young adulthood: an examination of socio‐demographic, contextual and psychosocial risk factors for attempted suicide in a longitudinal cohort of ageing adolescents affected by HIV living in the New York City Area
Authors: Kreniske Philip , Morrison Corey , Spencer Bailey Holmes , Levine Alina , Liotta Lucy , Fisher Prudence W. , Nguyen Nadia , Robbins Reuben N. , Dolezal Curtis , Kluisza Luke , Wiznia Andrew , Abrams Elaine J. , Mellins Claude A. 
Published: September 2022

AbstractIntroductionAs children become adolescents and young adults (AYA), their risk for attempting suicide increases dramatically, with chronic health conditions an important risk factor. This study examined correlates of suicidality across development in AYA living with perinatally acquired HIV (AYALPHIV) and those perinatally HIV‐exposed but uninfected (AYAPHEU).MethodsData come from an ongoing longitudinal New York City‐based study (N= 339) with AYALPHIV and AYAPHEU interviewed every 12–18 months from 2003 to 2019 (mean enrolment age = 12 years; current mean age = 27 years). The Diagnostic Interview Schedule for Children (adolescent or young adult version) assessed psychiatric disorders and first‐reported suicide attempt. Generalized estimating equations were used to examine associations between first‐reported suicide attempt and socio‐demographic, contextual and psychosocial correlates measured concurrently across six timepoints.ResultsAt enrolment, 51% of participants were female, 72% heterosexual, 60% Black and 50% Latinx. Attempted suicide was significantly higher among AYALPHIV (27%, CI 21–33%) compared to AYAPHEU (16%, CI 10–22%), with an OR of 1.74 (CI 1.04–2.92) in a model adjusting for age. For AYALPHIV, anxiety (OR 2.66, CI 1.46–4.85), mood (OR 3.62, CI 1.49–8.81) and behaviour disorders (OR 5.05, CI 2.15–11.87) and past‐year arrest (OR 3.05, CI 1.26–7.4), negative life events (OR 1.27, CI 1.11–1.46), city stress (OR 2.28, CI 1.46–3.57), pregnancy (OR 2.28, CI 1.08–4.81) and HIV stigma (OR 2.46, CI 1.27–4.75) were associated with increased odds of attempted suicide, while identifying as heterosexual (OR 0.27, CI 0.14–0.52), higher personal (OR 0.45, CI 0.26–0.80) and family self‐concept (OR 0.36, CI 0.22–0.57) were protective. Interactions by HIV status and age were found: substance use was more strongly associated with attempted suicide among AYAPHEU than AYALPHIV, while negative life events and higher religiosity were more strongly associated with increased odds of attempted suicide among AYA ≥ 19 versus ≤ 18 years.ConclusionsAYALPHIV compared to AYAPHEU faced unique risks for attempted suicide as they age into adulthood, with the highest risk among AYALPHIV experiencing HIV stigma or pregnancy and the highest risk among AYAPHEU with substance use. Assessing for suicide risk and correlates with attention to ageing can inform preventive interventions tailored to meet AYALPHIV and AYAPHEU needs.
Intraoperative frozen section analysis of margin status as a quality indicator in gastric cancer surgery
Authors: Watanabe Akie , Adamson Hannah , Lim Howard , McFadden Andrew F. , McConnell Yarrow J. , Hamilton Trevor D. 
Published: September 2022

AbstractIntroductionPositive pathologic margins following gastric cancer (GC) resection carries a poor prognosis. We evaluated intraoperative frozen section (IFS) analysis of resection margins (RMs) as a quality indicator in GC surgery.MethodsPatients referred to a provincial cancer agency with surgically resected non‐metastatic GC between 2004 and 2012 were included. Associations between IFS analysis, other baseline characteristics, RMs, and overall survival (OS) were assessed using logistic regression, Kaplan−Meier analyses, and Cox proportional hazards modeling.ResultsAmong 377 patients, median age was 67 years, 68% were male, and 16% had +RMs. Thirty‐four percent of patients underwent IFS analysis, which protected against +RMs (odds ratio [OR]: 0.34, 95% confidence interval [CI]: 0.16−0.73, p = 0.006) and improved OS (hazards ratio [HR]: 0.72, 95% CI: 0.54−0.98, p = 0.037). OS following re‐resection of IFS positive patients was similar to IFS negative patients (69 vs. 54 months, p = 0.317). Stage III disease (OR: 12.8, 95% CI: 3.00−55.0, p = 0.001) and gastroesophageal junction tumors (OR: 2.25, 95% CI: 1.05−4.78, p = 0.036) predicted +RMs. Stage III disease led to worse OS (HR: 2.89, 95% CI: 1.92−4.34, p < 0.001) while intestinal histology improved OS (HR: 0.67, 95% CI: 0.50−0.90, p = 0.007).ConclusionsIFS analysis reduce +RMs and improve OS and should be incorporated in curative intent GC surgery for patients with locally advanced GC.
The impact of race/ethnicity on pancreaticoduodenectomy outcomes for pancreatic cancer
Authors: Alwatari Yahya , Mosquera Catalina M. , Khoraki Jad , Rustom Salem , Wall Natalie , Sevdalis Athanasios E. , Stover Weston , Trevino Jose G. , Kaplan Brian 
Published: September 2022

AbstractPurposeTo investigate the impact of race/ethnicity on surgical outcomes following pancreaticoduodenectomy for pancreatic cancer.MethodsA retrospective review of patients undergoing pancreaticoduodenectomy for adenocarcinoma in the National Surgical Quality Improvement Program (NSQIP) database from 2014 to 2019. Patient and tumor characteristics and 30‐day postoperative outcomes were compared. Multivariable logistic and linear regression models were conducted to investigate the relationship between race/ethnicity and surgical outcomes.ResultsSix thousand five hundred and sixty‐two patients were included (84.5% White, 7.9% Black, 3% Hispanic, 4.6% Asian). Larger proportions of Blacks had preoperative American Society of Anesthesiologists class 3 or 4. There were no significant differences in tumor characteristics or operative techniques. A smaller proportion of Asians and Hispanics received neoadjuvant chemotherapy and/or radiation than Blacks and Whites. Relative to White, the Black race was independently associated with postoperative sepsis and reoperation. Both Black and Hispanic race/ethnicity were associated with prolonged intubation and delayed gastric emptying, and minorities races/ethnicities were associated with longer length of hospital stay. Relative to White, Hispanic, and Asian race/ethnicity were independently associated with a lower likelihood of neoadjuvant therapy (NAT) receipt.ConclusionIn ACS‐NSQIP participating hospitals, non‐White race/ethnicity was independently associated with adverse outcomes after pancreatic cancer resection. A possible disparity in NAT receipt may exist in Asian and Hispanic patients undergoing surgical resection.