bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agrocarburants : impacts au Sud ?
Authors: Ariza-Montobbio Pere , Lele Sharachchandra , Kallis Giorgos , Martinez-Alier Joan , Carlier Marielle 
Published: May 2022

En dépit de l’entreprise de légitimation du développement des plantations de jatropha pour la production de biodiesel en Inde, les résultats enregistrés dans l’État du Tamil Nadu ne plaident pas en faveur de cette option agricole et énergétique. La marginalisation des petits paysans et des cultures vivrières invalide de facto le double argument officiel de « valorisation des terres incultes » et de « lutte contre la pauvreté ».
Artificial intelligence in glaucoma
Authors: Nair Megha , Tagare Shivraj , Venkatesh Rengaraj , Odayappan Annamalai 
Published: May 2022

Background:
Artificial Intelligence (AI) is an area of computer science that encompasses the creation of intelligent machines that work and react like humans. It deals with the development algorithms that seek to simulate human brain and also mimic cognitive functions typically associated with the human mind such as learning and problem solving.

Purpose:
Do we need artificial intelligence in Glaucoma? Glaucoma is the second most common cause of blindness in the world. Its prevalence was over 60 million in 2010 and over 80 million by 2020. It is so common, yet so easily overlooked. More importantly, about 50% of patients in developed countries and 90% in developing countries are unaware of having glaucoma. Early detection can delay the progression of glaucoma. Hence the time is ripe to advovate glaucoma screening.

Synopsis:
The application of AI in ophthalmology mainly concentrates on the diseases with a high incidence, such as diabetic retinopathy, age-related macular degeneration, glaucoma, retinopathy of prematurity, age-related or congenital cataract etc AI involves mainly 1. machine learning that are algorithms with the ability to learn without being explicitly programmed and 2. deep learning in which artificial neural networks adapt and learn from vast amounts of data. But there are limitations to screening - such as disparity between ophthalmologist:patient ratio and also the availability of the specialty services. The large amount of data acquired from patients makes it nearly impossible for ophthalmologists to screen them with equal efficacy and consistency.

Highlights:
AI in glaucoma aims at including factors such as clinical data, genomic data, life style behaviors, risk factors, and medical history to predict the risk of developing glaucoma, help customise the most appropriate management protocol for a given patient, and estimate prognosis and surgical success.

Video Link:

https://youtu.be/IwYS7wDMhkY
Pattern of uveitis from a tertiary eye care center in Himalayan belt of North India
Authors: Pandurangan Sneha , Samanta Ramanuj , Kumawat Devesh , Sood Gitanjli , Devi Thounaojam S , Agrawal Ajai 
Published: May 2022

Purpose:
To study the clinical characteristics of uveitis in patients presenting to a tertiary care institute in the northern part of India, predominantly serving the population of Himalayan belt.

Methods:
In this retrospective descriptive case series, data of 141 eyes of 102 patients diagnosed between January 2019 and January 2021 were analyzed. Patients were diagnosed, named, and meshed as per the Standardization of Uveitis Nomenclature. A panel of investigations (systemic and ocular ancillary investigations) were done, which was individualized according to the clinical picture.

Results:
The mean age of presentation was 39.1 ± 14.62 years. A male predominance (62.7%) was noted. Unilateral presentation was seen in 61.8% of patients. Specific etiological diagnosis was not reached in 56.7% of cases. The incidence of infectious and noninfectious uveitis was 23.4% and 19.9%, respectively. The frequency of anterior, intermediate, posterior, and panuveitis was 23.4%, 11.3%, 46.8%, and 18.5%, respectively. Posterior uveitis was the most frequent anatomical location (46.8%). Tuberculous uveitis was the most common definitive etiology irrespective of location (18.5%). Anterior, intermediate, and posterior uveitis were more frequently idiopathic in origin. Sympathetic ophthalmitis was the most common cause for panuveitis.

Conclusion:
Uveitis significantly affected the working age group population. Despite the evolution of diagnostic investigations, etiology remained unknown in many cases of uveitis. Infectious etiology was more common. Posterior uveitis as the most frequent anatomical location in our study may be attributed to the tertiary care referral bias.
Ophthalmology practice in COVID-19 pandemic: Performance of rapid antigen test versus real time-reverse transcription polymerase chain reaction in a tertiary eye care institute in South India
Authors: Sarkar Sandip , Deb Amit Kumar , Singh Rakesh , Dhodapakar Rahul , Gokhale Tanmay , Kaliaperumal Subashini 
Published: May 2022

Purpose:
To assess the rapid antigen test (RAT) against the gold standard reverse transcription-polymerase chain reaction (RT-PCR) to screen COVID-19 infection in asymptomatic patients undergoing ophthalmic procedures.

Methods:
This was a retrospective hospital-based study. Point-of-care (PoC) RAT was performed using nasopharyngeal swab, while RT-PCR for SARS-CoV-2 viral RNA was performed using both nasopharyngeal and throat swabs.

Results:
A total of 629 patients were tested for SARS-CoV-2 by using both RAT and RT-PCR. Only one patient had tested positive for SARS-CoV-2 with both RAT and RT-PCR, while two patients had tested positive with RT-PCR after an initial negative RAT. The positivity rate for RAT was 0.15% (1/629), and that for RT-PCR was 0.47%. Percent agreement or proportion of agreement observed between the two tests was 99.68%, while Cohen’s kappa coefficient value was 0.49. The sensitivity of RAT in comparison to RT-PCR was 33.33%, specificity was 100%, positive predictive value was 100%, and negative predictive value was 99.68%.

Conclusion:
The sensitivity and Cohen’s kappa coefficient in our study were low but that can be attributed to the overall low positivity rates with both RAT and RT-PCR. However, percent agreement observed between the two tests was very high. Therefore, we recommend initial screening of all the patients for COVID-19 symptoms followed by RAT before performing any ophthalmic surgical procedure to ensure the safety of the health care professionals as well as the patients.
Assessing contrast sensitivity change in retinal diseases with use of yellow-amber NoIR glasses
Authors: Sodhi Punita Kumari , Gautam Akanksha , Sharma Nandini , Rustagi Ruchir , Jaisingh Kirti , Sodhi Ramneeq Singh 
Published: May 2022

Purpose:
The purpose of this study was to assess change of contrast sensitivity (CS) in subjects having retinal diseases with yellow-amber no infrared (NoIR) glasses used as low vision aid (LVA).

Methods:
We examined CS in 82 low vision (LV) subjects having retinal diseases with Pelli Robson Chart at 1 m distance before and after wearing yellow-amber NoIR glasses. We also found type of retinal affection and macular optical coherence tomography (OCT) features.

Results:
The distance and near best-corrected visual acuity (BCVA) was, respectively, 0.68 ± 0.17 (median = 0.70) and 0.72 ± 0.25 (median = 0.70) logmar units. The pre-LVA CS was 0.52 ± 0.29 (median = 0.3) and post- LVA was 0.52 ± 0.28 (median = 0.45) logunits (mean reduction = -0.002 ± 0.24; Median reduction = 0; P = 0.909). The pre-LVA and post-LVA CS showed a negative correlation with logmar distance BCVA [r = -0.090; P = 0.317 and r = -0.152; P = 0.090 respectively]. The pre-LVA and post-LVA CS showed a negative correlation with logmar near BCVA [r = -0.114; P = 0.207 and r = -0.054; P = 0.549 respectively]. The CS did not improve in subjects having macular degeneration, pathological myopia, hereditary maculopathy, and diabetic retinopathy. The macular OCT features like fluid, exudates, scars, drusens, traction, and hole did not significantly influence CS both at pre-LVA and post-LVA stage.

Conclusion:
This is the first study with yellow-amber NoIR glasses which blocks “both ultraviolet and infrared light.” The subjects having macular degeneration, pathological myopia, hereditary maculopathy, and diabetic retinopathy did not improve in CS with filters. The correlation values showed that filters may improve CS in subjects having good baseline BCVA.
Analysis of COVID-19 publications in the Indian Journal of Ophthalmology during two years of the pandemic and their impact on ophthalmic literature
Authors: Gurnani Bharat , Kaur Kirandeep 
Published: May 2022

Purpose:
To perform a comprehensive analysis of COVID-19 publications published in the Indian Journal of Ophthalmology (IJO) during the two years of the pandemic and to study their impact on ophthalmic literature.

Methods:
A retrospective analysis was performed of all expedited COVID-19 articles published in IJO from April 2020 to March 2022. The data was obtained from the official website of IJO, editor IJO monthly emails, and PubMed database. The data was then extracted as XML into Microsoft Access for scientometric analysis. The expedited articles were segregated into different categories: original, review, case report/series, letter to the editor, commentary, current ophthalmology, consensus criteria, perspective, innovations, ophthalmic images, photoessays, research methodology, and surgical techniques. The monthly data was analyzed and COVID-19 articles were assessed for subspecialty-wise distribution, number of citations, monthly growth rate, and their impact on ophthalmic literature.

Results:
A total of 431 COVID-19 related articles were published during the study period. The majority of the articles were letters to the editor (158, 36.65%) followed by original articles (97, 22.50%), and commentaries (53, 12.29%). The least were perspectives and ophthalmic images (2, 0.46%) each followed by consensus criteria (1, 0.23%). The maximum publications came in July 2020 (44, 10.20%) followed by December 2021 (37, 8.58%) and October 2021 (36, 8.35%), and the least were in April 2020 (1, 0.23%). Considering subspecialty, a majority of the articles were related to general ophthalmology (156, 36.19%), and the least was in oncology (2, 0.46%). The maximum number of citations were attracted by original articles (97, 1146 (11.81)), which were approximately 1.5 times higher than the letters to the editor (158, 743 (4.70)) and 3 times higher than review articles (9, 387 (43)). Among specialties, the maximum number of citations were gathered by general ophthalmology (156, 1320 (8.46)) followed by oculoplasty (36, 592 (16.44)) due to the concurrent mucormycosis epidemic.

Conclusion:
IJO opened a window of opportunity for authors by publishing quality expedited articles. Evidence-based orbital mucormycosis and general ophthalmology publications gathered most of the attention due to their heterogeneous presentation. The peak of the first wave (June–July 2020) and the October and December 2021 issues had maximum number of COVID-19 articles.
A short-term chick embryo in vivo xenograft model to study retinoblastoma cancer stem cells
Authors: Nair Rohini M , L Revu Narayana V , Gali Sucharita , Kallamadi Prathap Reddy , Prabhu Varsha , Manukonda Radhika , Nemani Harishankar , Kaliki Swathi , K Vemuganti Geeta 
Published: May 2022

Purpose:
Cancer stem cells (CSCs) reported in various tumors play a crucial role in tumorigenesis and metastasis of retinoblastoma (Rb). Following the efforts to reduce, replace, and refine the use of mammalian models, we aimed to establish a short-term xenograft for Rb to evaluate the CSC properties of CD133- Rb Y79 cells, using the well-established chick embryo chorioallantoic membrane (CE-CAM) assay.

Methods:
Y79 cells were cultured, labeled with two different dyes (CM-Dil Y79 and enhanced green fluorescent protein (eGFP)) and sorted for CD133- and CD133 + subsets. Two million cells from each of the labeled groups were transplanted onto the abraded CAM on embryonic day 7 (E7). On E14, the tumor nodule formation on CAM and spontaneous metastasis to the embryos were evaluated by confocal microscopy, in vivo imaging, and histology.

Results:
Y79 cells formed pink–white raised perivascular nodules with feeder vessels on the CAM with both the types of labeled CD133- cells. CD133- cells, when compared to CD133 + cells, demonstrated significantly larger tumor volume (40.45 ± 7.744 mm3 vs 3.478 ± 0.69 mm3, P = 0.0014) and higher fluorescence intensity (CM-Dil: AUF = 6.37 × 107 ± 7.7 × 106 vs 1.08 × 107 ± 1.6 × 106; P < 0.0001; eGFP: AUF = 13.94 × 104 ± 2.54 × 104 vs AUF = 1.39 × 104 ± 0.4 × 104; P = 0.0003). The metastatic potential of CD133- cells was also observed to be higher as noted by in vivo imaging and histopathology.

Conclusion:
This study highlights that CE-CAM is a feasible alternative nonmammalian model for evaluating tumorigenicity and metastatic potential of Y79 CSCs. Increased tumorigenicity and metastatic potential of CD133- subset of tumor cells substantiate their CSC properties.
Can virtual reality surgical simulator improve the function of the non-dominant hand in ophthalmic surgeons?
Authors: Eltanamly Rasha M , Elmekawey Hany , Youssef Maha M , Hassan Lameece M 
Published: May 2022

Purpose:
Phacoemulsification surgery requires the use of both hands; however, some surgeons may not be comfortable using their non-dominant hand, especially in critical steps such as chopping. This work aims at assessing whether a virtual reality simulator can help cataract surgeons train their non-dominant hand using the capsulorhexis module.

Methods:
This was a prospective observational study including thirty ophthalmic surgeons; none of them had previous training on the EyeSi surgical simulator. Twenty-three were experienced, and seven were intermediate surgeons. Surgeons were asked to perform capsulorhexis three times using their dominant hand and then using their non-dominant hand. A performance score based on efficiency, target achievement, instrument handling, and tissue treatment was calculated by the simulator.

Results:
A significant improvement in the score of surgeons using their non-dominant hand from the first trial (69.57 ± 18.9) to the third trial (84.9 ± 9.2) (P < 0.001) was found, whereas such improvement was not noted with the dominant hand (P = 0.12). Twenty-six surgeons managed to reach 90% of the mean score achieved by dominant hand by using their non-dominant hand, 11 (36.7%) from the first trial, seven (23.3%) from the second, and eight (26.7%) from the third.

Conclusion:
Cataract surgeons showed significant improvement in the scores of their non-dominant hands with simulator training. Thus, it is possible to safely train non-dominant hands for difficult tasks away from the operating room, which would be a fruitful addition to residency training programs.
Pre-operative optical coherence tomography predictors: Do they hold any relevance in the era of inverted internal limiting membrane flap in large macular holes?
Authors: Narnaware Shilpi H , Bawankule Prashant K , Bansal Anju , Chakraborty Moumita , Raje Dhananjay , Nagdeve Rakesh , Chivane Anurag 
Published: May 2022

Purpose:
To study the relevance of preoperative OCT predictors in large macular holes (MH) treated using the inverted ILM peel technique.

Methods:
Prospective study of 95 patients undergoing vitrectomy for large MH between January 2019 and December 2020 was performed by dividing the patients into groups depending on various quantitative parameters and indices of MH such as base diameter (BD), hole form factor (HFF), macular hole index (MHI), diameter hole index (DHI), and tractional hole index (THI) by using parameters such as minimal hole diameter, hole height, nasal and temporal arm lengths. Depending upon the duration of symptoms, patients were divided into three groups: <3 months, 3–6 months, and >6 months. Anatomical success rate, type of closure, and postoperative vision gain were analyzed in relation to the abovementioned diameters, indices, and duration to see if any significance existed.

Results:
The mean age of patients included in the study was 60.48 ± 13.88 years, with female preponderance (males: females = 37:58). Change in logMAR was statistically significant individually with all studied parameters (P < 0.0001) without influence of size of hole and other indices. BD and DHI levels showed significant association with type of closure as indicated by P values of 0.017 and 0.048, respectively. Duration of symptoms showed no significance in terms of anatomical and functional success.

Conclusion:
OCT predictors of MH success seem to have lost relevance with inverted flap surgeries as 100% anatomical success is achieved with this technique, with 95.78% (91/95) achieving type 1 closure with statistically significant equivalent functional gain across the indices with no effect of duration of symptoms.
Does methylphenidate treatment affect functional and structural ocular parameters in patients with attention deficit hyperactivity disorder? - A prospective, one year follow-up study
Authors: Bingöl-Kızıltunç Pınar , Yürümez Esra , Atilla Huban 
Published: May 2022

Purpose:
Methylphenidate hydrochloride, which blocks the reuptake mechanisms of dopamine and norepinephrine, is used in attention deficit hyperactivity disorder (ADHD) treatment. Methylphenidate has many general side effects including ocular findings. In this study, we investigated the long-term effects of methylphenidate treatment on functional and structural ocular parameters.

Methods:
In this prospective study, children with ADHD were evaluated. All patients underwent a detailed ophthalmic examination before methylphenidate treatment. All patients were examined in the 3rd, 6th, 9th, 12th months of methylphenidate treatment. Visual acuities, color vision, pupil diameters, static, dynamic and cycloplegic retinoscopy, intraocular pressure (IOP), anterior chamber depth (ACD), axial length (AL) were evaluated and recorded.

Results:
A total of 22 children were included in this study. The best-corrected visual acuities (BCVA) of all patients for both eyes were 0.0 logMAR, and 90.9% of patients had blue–purple color weakness before the treatment. After 1 year of treatment, none of the patients had any change in BCVA and color vision. However, an increase in myopic values of static retinoscopy and a decrease in hyperopic values of cycloplegic retinoscopy were found. Additionally, accommodation capacities were found to be decreased and AL was found to be increased significantly for both eyes. Pupil diameter, IOP, and ACD values did not change significantly.

Conclusion:
Our results suggest that patients with ADHD may have blue color vision deficiencies because of the decreased retinal dopamine levels. Additionally, structural and ocular parameters, especially accommodation capacity, may be affected by methylphenidate treatment.
Management of descemetocele: Our experience and a simplified treatment algorithm
Authors: Shankar Sree , Agarwal Rinky , Nagpal Ritu , Maharana Prafulla K , Goel Siddhi , Sinha Rajesh , Agarwal Tushar , Titiyal Jeewan Singh , Sharma Namrata 
Published: May 2022

Purpose:
To formulate a treatment algorithm for the management of descemetocele.

Methods:
This was a prospective interventional study that was conducted at a tertiary eye-care center. All consecutive cases of descemetocele during the study period (April 1, 2017–March 31, 2018) were evaluated for the following parameters: age, sex, previous medical or surgical therapy, risk factors, preexisting ocular diseases, location, site and size of descemetocele, interventions undertaken, visual acuity, and the fellow eye status. The surgical modalities and fellow eye status were correlated individually with therapeutic and functional outcomes, based on which a treatment algorithm was formulated.

Results:
The study included 24 eyes of 24 patients (19M, 5F) with a median age of presentation of 45 years. The mean follow-up duration was 6.79 ± 3.97 months (3–12 months). The most common cause of descemetocele was microbial keratitis (66.66%), and most cases were central (50%), small (58.33%), and non-perforated (79.16%). The surgical interventions undertaken were cyanoacrylate glue (CG, 37.5%), penetrating keratoplasty (PKP, 33.33%), patch graft (16.66%), and deep anterior lamellar keratoplasty (DALK, 12.5%). Therapeutic success was noted in 13/24 eyes (54.16%). Final visual acuity > 3/60 was seen in 25% cases. Suboptimal therapeutic (P = 0.07) and visual (P = 0.34) outcomes were noted in subjects with non-functional fellow eye.

Conclusion:
PKP was preferred for descemetoceles with active microbial keratitis and extensive infiltrates, while CG and DALK were undertaken for healed microbial keratitis, neurotrophic keratitis, and ocular surface disorders with partial limbal stem cell deficiency (LSCD). For total LSCD, amniotic membrane graft was preferred.
Psychosocial assessment among ophthalmic patients attending tertiary eye care centre during the lockdown in times of COVID-19 pandemic
Authors: Sanjay Srinivasan , Venkatesh Ramesh , Tejwani Sushma , Jayadev Chaitra , Nanavati Hardik , Mohapatra Ayushi , Khamar Pooja , Nuijts Rudy , Dickman Mor , Shetty Rohit 
Published: May 2022

Purpose:
The coronavirus disease (COVID-19) pandemic continues to play havoc in our lives. During the first “ lockdown” in 2020, we were keen on assessing the anxiety levels of patients who sought ophthalmic care despite the lockdown. Public health actions, such as social distancing, were necessary to reduce the spread of COVID-19. As a result, most people felt isolated and lonely, thereby causing increased levels of stress and anxiety in them. We aimed to assess the anxiety levels using the Hamilton Anxiety Scale and personality assessment using the 57-point Eysenck’s Personality Inventory (EPI) questionnaire among patients visiting a tertiary eye care hospital during the lockdown period.

Methods:
Consecutive patients attending an ophthalmic tertiary care hospital during the COVID-19 pandemic and lockdown were approached to be a part of this prospective cross-sectional survey.

Results:
In total, 1,088 responses were analyzed during the 2-month study period with the mean age being 45.7 + 16.9 years. The majority had completed graduation (78%) with 15 years or more of formal education. The purpose of the visit was an emergency consultation in 42% (n = 455), a review appointment in 42% (n = 457), and the remaining (16%, n = 176) came for a routine consultation. The majority of the patients (>90%) did not report experiencing any of the 14 sets of symptoms. A mild level of anxiety was noted in 1,086 (>99%) respondents, whereas only 2 (<1%) respondents showed mild–moderate levels of anxiety. Financial concerns such as affordability of medications (6% vs. 3%, P
= 0.05) and fear of losing their job (16% vs. 11%, P = 0.02) were significantly more in those experiencing any anxiety compared to those with no anxiety.

Conclusion:
Our study revealed that patients visiting a tertiary ophthalmic center during lockdown were graduates, sought eye consultation primarily for emergency or a review, and had no major anxiety symptoms. In those with anxiety, the affordability of medicines and loss of jobs were the main concerns.