bluuebunny/crossref_metadata_2025_split huggingface dataset:
Buprenorphine/naloxone versus methadone opioid rotation in patients with prescription opioid use disorder and chronic pain: study protocol for a randomized controlled trial
Authors: Ellerbroek Hannah , van den Heuvel Sandra A. S. , Dahan Albert , Timmerman Hans , Kramers Cornelis , Schellekens Arnt F. A. 
Published: September 2022

Abstract
Background
Opioids are effective in pain-management, but long-term opioid users can develop prescription opioid use disorder (OUD). One treatment strategy in patients with OUD is rotating from a short-acting opioid to a long-acting opioid (buprenorphine/naloxone (BuNa) or methadone). Both BuNa and methadone have been shown to be effective strategies in patients with OUD reducing opioid misuse, however data on head-to-head comparison in patients with chronic non-malignant pain and prescription OUD are limited.

Methods
This two-armed open-label, randomized controlled trial aims to compare effectiveness between BuNa and methadone in patients with chronic non-malignant with prescription OUD (n = 100). Participants receive inpatient rotation to either BuNa or methadone with a flexible dosing regimen. The primary outcome is opioid misuse 2 months after rotation. Secondary outcomes include treatment compliance, side effects, analgesia, opioid craving, quality of life, mood symptoms, cognitive and physical functioning over 2- and 6 months follow-up. Linear mixed model analysis will be used to evaluate change in outcome parameters over time between the treatment arms.

Discussion
This is one of the first studies comparing buprenorphine/naloxone and methadone for treating prescription OUD in a broad patient group with chronic non-malignant pain. Results may guide future treatment for patients with chronic pain and prescription OUD.
Trial registrationhttps://www.trialregister.nl/, NL9781
Coping motives mediate the relationship between PTSD and MDMA use in adolescents with substance use disorders
Authors: Basedow Lukas Andreas , Wiedmann Melina Felicitas , Roessner Veit , Golub Yulia , Kuitunen-Paul Sören 
Published: September 2022

Abstract
Background
Post-traumatic stress disorder (PTSD) and substance use disorders (SUDs) often co-occur in adolescent patients. Previous research has shown that these patients differ from SUD patients without PTSD in terms of their substance use patterns. In this study, we aimed to test whether substance use in this population is related to an attempt to self-medicate PTSD-related symptoms.

Methods
German adolescent patients (aged 13–18 years) at an outpatient clinic for SUD treatment, n = 111 (43% female), completed a self-designed questionnaire on use motives, a measure of PTSD-related experiences, and underwent a standardized psychiatric interview including structured substance use questions. Participants were subsequently classified as ‘no traumatic experiences (‘noTEs’ but SUD), ‘traumatic experiences but no current PTSD diagnosis’ (‘TEs’ with SUD), and ‘PTSD’ with SUD. After establishing a self-designed motive measurement through exploratory and confirmatory factor analyses, we calculated non-parametric group differences and a mediation analysis in a linear regression framework.

Results
The past-year frequency of MDMA use was highest in the PTSD group and lowest in the noTE group (H (2) = 7.2, p = .027, η2 = .058), but no differences were found for frequencies of tobacco, alcohol, cannabis, or stimulant use (all H ≤ 4.9, p ≥ .085, η2 ≤ .033). While controlling for sex, the three groups showed a similar pattern (highest in the PTSD group and lowest in the noTE group) for coping scores (F (103) = 5.77, p = .004, η2 = .101). Finally, mediation analyses revealed an indirect effect of coping score (b = 0.61, 95% CI [0.29, 1.58], p = .145) on the association between group membership and MDMA use frequency.

Conclusions
In adolescent SUD patients, we found an association of current PTSD and lifetime traumatic experiences with higher MDMA use that could be partially explained by substance use being motivated by an attempt to cope with mental health symptoms. This indicates a coping process involved specifically in MDMA use compared to the use of other psychoactive substances, possibly due to unique psychoactive effects of MDMA.
The role of smallholder bean farmers in determining farm gate prices for beans in Uganda
Authors: Jjagwe George , Kibwika Paul , Mazur Robert , Sseguya Haroon 
Published: September 2022

Abstract
Background
Like for other agricultural commodities, the bean value chain involves a series of actors including; farmers as producers, middlemen, retailers, wholesalers and exporters. The study explains the common bean (Phaseolus vulgaris) marketing constraints faced by smallholder bean farmers and other actors in the bean value market chain that need redress for efficient and effective bean marketing in Uganda. Specifically, the effect of farmer bean production and marketing modes, and limited knowledge about bean market requirements on the final prices received for their beans and their limited ability to demand better prices is explained by the study. A descriptive cross-sectional design was used to collect data from 127 farmers (in strata of trained and non-trained farmers), 34 traders, five input dealers and 40 consumers, using semi structured questionnaires, and interview guides. Quantitative and qualitative data were analysed using SPSS and content analysis, respectively.

Results
Trained farmers produced more beans in the two seasons though the mean difference was not statistically significant from the non-trained farmers. Farmers determine the quantity of beans sold and not the prices. Both trained and non-trained farmers consider the price offered by traders through consultations. Most farmers individually sold their beans with little role in determining prices. Farmers formed groups to better access inputs and improve their bargaining power. Variety, price and quality influenced consumer purchase decisions. NABE 15 K132, NABE4, Yellow and white beans were preferred varieties. Trained farmers sold beans at a higher price of USD 0.505 per kilo gram, while non-trained farmers sold at USD 0.369 per kilo gram. The records kept by majority of the farmers pertain either to dates particular activities were executed or when they received visitors, and could neither be used in determining the bean prices nor costing production.

Conclusions
The constraints faced by the different bean actors provide a basis for developing bean marketing models. Addressing smallholders’ marketing challenges will increase their incomes and boost production. Increase in income through increased prices for farmers will improve farmer living standards as they will be able to meet basic needs. The quantity increase in production will partly address the food insecurity problems through direct consumption and selling the excess to buy other desired foods.
Transmission and mortality risk assessment of severe fever with thrombocytopenia syndrome in China: results from 11-years' study
Authors: Chen Qiulan , Yang Dong , Zhang Yanping , Zhu Mantong , Chen Ning , Yushan Zainawudong 
Published: September 2022

Abstract
Background
The transmission and fatal risk of severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease first discovered in China in 2009, still needed further quantification. This research aimed to analyze the SFTS clusters and assess the transmission and mortality risk for SFTS.

Methods
Both epidemiological investigation and case reports regarding SFTS clusters in China during 2011–2021 were obtained from the Public Health Emergency Information Management System of the Chinese Center for Disease Control and Prevention Information System. The transmission risk was evaluated by using the secondary attack rate (SAR) and relative risk (RR). Mortality risk factors were analyzed using a logistic regression model.

Results
There were 35 SFTS clusters during 2011–2021 involving 118 patients with a fatality rate of 22.0%. The number of clusters annually increased seasonally from April to September. The clusters mainly occurred in Anhui (16 clusters) and Shandong provinces (8 clusters). The SAR through contact with blood or bloody fluids was much higher than that through contact with non-bloody fluids (50.6% vs 3.0%; χ2 = 210.97, P < 0.05), with an RR of 16.61 [95% confidence interval (CI): 10.23–26.97]. There was a statistically significant difference in the SAR between exposure to the blood of a deceased person during burial preparation and exposure to the living patients’ blood (66.7% vs 34.5%; χ2 = 6.40, P < 0.05), with an RR of 1.93 (95% CI: 1.11–3.37). The mortality risk factors were a long interval from onset to diagnosis [odds ratio (OR) = 1.385), 95% CI: 1.083–1.772, P = 0.009) and advanced age (OR: 1.095, 95% CI: 1.031–1.163, P = 0.01).

Conclusions
The SFTS clusters showed a high mortality rate and resulted in a high SAR. Contact with a bleeding corpse was associated with a higher infection risk, compared with contacting the blood from living patients. It is important to promote early detection and appropriate case management of patients with SFTS, as well as improved handling of their corpses, to prevent further transmission and mortality.

Graphical abstract
Associations between psychosocial risk factors, and changes in substance dependence and psychosocial functioning, during engagement with digital cognitive behavioral therapy for methamphetamine use: use of 'Breaking Free from Substance Abuse' by incarcerated people during the COVID-19 pandemic
Authors: Elison-Davies Sarah , Newsome Jamie , Jones Andrew , Davies Glyn , Ward Jonathan 
Published: September 2022

AbstractBackgroundMethamphetamine use can be associated with involvement with correctional services and incarceration. Traditionally, treatments for methamphetamine use have been delivered in-person – however, lockdowns initiated during the COVID-19 pandemic significantly reduced access to such in-person support in prisons. Therefore, in May 2020 a digital cognitive-behavioral therapy (CBT) program for substance use disorders - 'Breaking Free from Substance Abuse' - was made available across prisons in Ohio in order to meet this treatment gap. This represents the first time this digital CBT intervention has been made widely available to incarcerated people residing in prisons or jails in the United States (US). This was a within-subjects study using data from 2187 Ohio prison residents who engaged with this digital CBT program to address their methamphetamine use.ResultsParticipants reported multiple psychosocial risk factors, including moderate to severe substance dependence, depression and anxiety; interpersonal conflict; aggressive behavior; paranoia; and difficulties with work, education and accommodation. Significant reductions in substance dependence, depression/anxiety and biopsychosocial impairment, and improvements in quality of life, were identified in the sample. Risk factors were associated with less positive outcomes, specifically interpersonal conflict and poor mental health. Completion of specific components of the program were associated with more positive outcomes – a dose response was also identified.ConclusionsDigital CBT can be delivered in secure US correctional settings and may help to fill unmet needs for in-person treatment. Specifically, this digital CBT program may support incarcerated individuals to address methamphetamine use, with outcomes being associated with psychosocial risk factors and program engagement.
In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variants
Authors: Bauer Lisa , Rissmann Melanie , Benavides Feline F. W. , Leijten Lonneke , van Run Peter , Begeman Lineke , Veldhuis Kroeze Edwin J. B. , Lendemeijer Bas , Smeenk Hilde , de Vrij Femke M. S. , Kushner Steven A. , Koopmans Marion P. G. , Rockx Barry , van Riel Debby 
Published: September 2022

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with various neurological complications. Although the mechanism is not fully understood, several studies have shown that neuroinflammation occurs in the acute and post-acute phase. As these studies have predominantly been performed with isolates from 2020, it is unknown if there are differences among SARS-CoV-2 variants in their ability to cause neuroinflammation. Here, we compared the neuroinvasiveness, neurotropism and neurovirulence of the SARS-CoV-2 ancestral strain D614G, the Delta (B.1.617.2) and Omicron BA.1 (B.1.1.529) variants using in vitro and in vivo models. The Omicron BA.1 variant showed reduced neurotropism and neurovirulence compared to Delta and D614G in human induced pluripotent stem cell (hiPSC)-derived cortical neurons co-cultured with astrocytes. Similar differences were obtained in Syrian hamsters inoculated with D614G, Delta and the Omicron BA.1 variant 5 days post infection. Replication in the olfactory mucosa was observed in all hamsters, but most prominently in D614G inoculated hamsters. Furthermore, neuroinvasion into the CNS via the olfactory nerve was observed in D614G, but not Delta or Omicron BA.1 inoculated hamsters. Furthermore, neuroinvasion was associated with neuroinflammation in the olfactory bulb of hamsters inoculated with D614G. Altogether, our findings suggest differences in the neuroinvasive, neurotropic and neurovirulent potential between SARS-CoV-2 variants using in vitro hiPSC-derived neural cultures and in vivo in hamsters during the acute phase of the infection.
Mindfulness and psychological well-being in adolescents: the mediating role of self-compassion, emotional dysregulation and cognitive flexibility
Authors: Yousefi Afrashteh Majid , Hasani Fereshteh 
Published: September 2022

AbstractIntroductionAdolescence is a critical period of growth. Mental health during adolescence is one of the most important determinants of mental health in adulthood. The aim of this study was to analyze the relationship between mindfulness and psychological well-being of adolescents considering the mediating role of self-compassion, emotional dysregulation and cognitive flexibility.MethodsThe method of this research is cross-sectional. The research population was adolescents (elementary, first and second high school) in Zanjan, Iran in 2021, whose approximate number was 14,000. Data through adolescent mindfulness questionnaires (Brown, West, Loverich, and Biegel, 2011), short form of psychological well-being questionnaire (Ryff and Keyes, 1995), short form of self-compassion scale (Raes et al., 2011), difficulty in Emotion regulation (Gratz and Roemer, 2004) and cognitive flexibility (Dennis and Vander Wal, 2010) were collected. Data analysis was performed using Pearson correlation coefficient and path analysis with SPSS-26 and lisrel-10.2 software.ResultsAccording the results, in addition to the fact that mindfulness is directly and positively related to psychological well-being (p < 0.05), it is also indirectly through self-compassion and Cognitive flexibility has a positive and significant relationship with psychological well-being and also mindfulness has an indirect, negative and significant relationship with psychological well-being through emotional dysregulation (p < 0.05). The results supported the goodness of model fit and confirmation of hypotheses.ConclusionTherefore, it is recommended that practitioners provide the basis for promoting psychological well-being through mindfulness, emotional dysregulation, self-compassion and cognitive flexibility.
Comparison of the accuracy of bracket positioning between direct and digital indirect bonding techniques in the maxillary arch: a three-dimensional study
Authors: Aboujaoude Rami , Kmeid Roland , Gebrael Carine , Amm Elie 
Published: September 2022

Abstract
Background/objectives
When the indirect bonding technique was developed in 1972 by Silverman and Cohen, many authors wondered whether this technique would improve bracket positioning accuracy compared to the direct bonding technique. Studies have found little to no difference between them regarding positioning accuracy. Recently, technological advances have improved the indirect method by allowing the user to position the brackets virtually using software applications such as OrthoAnalyzer™. To the best of our knowledge, no studies have compared direct positioning to this new digital indirect technique. Thus, the aim of this study was to compare the accuracy of placement between the two techniques in the maxillary arch using two different bracket types: conventional twin brackets and self-ligating brackets. A secondary objective was to evaluate whether bracket type affected positioning accuracy.

Methods
A maxillary arch of a patient was scanned by digital impression. Forty resin duplicates of this model were printed and then mounted on a mannequin head, on which 20 practitioners performed direct bonding using the aforementioned brackets. Later on, they performed a virtual indirect bonding of the same case virtually, with the digital impression superimposed to the patient’s CBCT (cone-beam computed tomography). Afterwards, the direct bonded models were unmounted, scanned, and then superimposed to the indirect models. Differences in height, angulation and mesio-distal position of the brackets were evaluated.

Results
Regarding height, the differences between direct and indirect methods were not significant. Height difference was significantly greater for self-ligating brackets compared to conventional brackets. Regarding mesio-distal positioning, significant differences were noted for teeth 13 and 15 with self-ligating brackets (p-value = 0.019 and p-value = 0.043, respectively). The deviation was also greater for these brackets. Regarding angulation, the difference was significant on tooth 12 when using conventional brackets (p-value = 0.04) and on 12 and 22 when using self-ligating brackets (p-value = 0.09).

Conclusion/implications
There were no major significant differences between direct and indirect bonding. Differences were significant only on the laterals for of angulation, and on teeth 13 and 15 for mesio-distal centering. The bracket type seems to influence positioning accuracy, since self-ligating brackets had a larger deviation range than conventional brackets.
Finite element simulation of permeable fault influence on a medium deep borehole thermal energy storage system
Authors: Seib Lukas , Welsch Bastian , Bossennec Claire , Frey Matthis , Sass Ingo 
Published: September 2022

AbstractSolutions for seasonal energy storage systems are essential for the reliable use of fluctuating renewable energy sources. As part of the research project SKEWS, a medium deep borehole thermal energy storage system with a depth of 750 m is under construction at Campus Lichtwiese in Darmstadt, Germany, to demonstrate this innovative technology. Prior to the design of SKEWS, the geological context in the surroundings of the project location was investigated using archive drilling data and groundwater measurements. The geologic survey suggests the assumption that the uppermost part of the intended storage domain is crosscut by a normal fault, which displaces the Permian rocks east of Darmstadt against granodioritic rocks of the Odenwald crystalline complex. A 3D finite-element numerical model was implemented to estimate the effect of the potentially higher hydraulic conductivity of the fault zone on the planned storage system. For this purpose, a storage operation over a time span of 30 years was simulated for different parametrizations of the fault zone. The simulations reveal a limited but visible heat removal from the storage region with increasing groundwater flow in the fault zone. However, the section of the borehole thermal energy storage system affected by the fault is minor compared to the total depth of the system. This only constitutes a minor impairment of the storage efficiency of approximately 3%. In total, the amount of heat extracted varies between 320.2 GWh and 326.2 GWh for the different models. These findings can be helpful for the planning and assessment of future medium deep borehole thermal energy storage systems in fractured and faulted crystalline settings by providing data about the potential impact of faults or large fractures crosscutting the storage system.
Comparison of two porcine acute lung injury models: a post-hoc analysis
Authors: Rissel René , Renz Miriam , Mohnke Katja , Riedel Julian , Ritter Katharina , Ziebart Alexander , Ruemmler Robert , Hartmann Erik K. , Kamuf Jens 
Published: September 2022

Abstract
Background
Acute respiratory distress syndrome (ARDS) is a common disease in intensive care medicine. Despite intensive research, mortality rates are high, not even in COVID-19 ARDS. Thereby, pigs offer some advantages to study the characteristics of ARDS. Many different ARDS models exist. Most of the articles published focused on histopathological and microscopic lung alterations to identify the most suitable animal ARDS model. “Macroscopic” observations and descriptions are often missing. Therefore, we performed a post-hoc comparison of two common ARDS models for pigs: lipopolysaccharide (LPS) vs. a double-hit model (bronchoalveolar lavage + oleic acid infusion). We investigated hemodynamic, spirometric and laboratory changes as another main clinical part of ARDS.

Results
The groups were compared by two-way analysis of variance (ANOVA) with a post-hoc Student–Newman–Keuls test. A p value lower than 0.05 was accepted as significant. All animals (n = 8 double-hit ARDS; n = 8 LPS ARDS) survived the observation period of 8 h. ARDS induction with reduced oxygen indices was successful performed in both models (76 ± 35/225 ± 54/212 ± 79 vs. 367 ± 64; T0/T4/T8 vs. BLH for double-hit; 238 ± 57/144 ± 59 vs. 509 ± 41; T4/T8 vs. BLH for LPS; p < 0.05). ARDS induced with LPS leads to more hemodynamic (mean arterial pulmonary pressure 35 ± 3/30 ± 3 vs. 28 ± 4/23 ± 4; T4/T8 LPS vs. double-hit; p < 0.05; doses of norepinephrine 1.18 ± 1.05 vs. 0.11 ± 0.16; LPS vs. double-hit for T8; p < 0.05) and inflammatory (pulmonary IL-6 expression: 2.41e−04 ± 1.08e−04 vs. 1.45e−05 ± 7.26e−06; LPS vs. double-hit; p < 0.05) alterations. ARDS induced by double-hit requires a more invasive ventilator strategy to maintain a sufficient oxygenation (PEEP at T4: 8 ± 3 vs. 6 ± 2; double-hit vs. LPS; p < 0.05).

Conclusions
Both animal ARDS models are feasible and are similar to human presentation of ARDS. If your respiratory research focus on hemodynamic/inflammation variables, the LPS-induced ARDS is a feasible model. Studying different ventilator strategies, the double-hit ARDS model offers a suitable approach.