bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Intelligence in the Era of Precision Oncological Imaging
Authors: Cellina Michaela , Cè Maurizio , Khenkina Natallia , Sinichich Polina , Cervelli Marco , Poggi Vittoria , Boemi Sara , Ierardi Anna Maria , Carrafiello Gianpaolo 
Published: November 2022

Rapid-paced development and adaptability of artificial intelligence algorithms have secured their almost ubiquitous presence in the field of oncological imaging. Artificial intelligence models have been created for a variety of tasks, including risk stratification, automated detection and segmentation of lesions, characterization, grading and staging, prediction of prognosis, and treatment response. Soon, artificial intelligence could become an essential part of every step of oncological workup and patient management. Integration of neural networks and deep learning into radiological artificial intelligence algorithms allow for extrapolating imaging features otherwise inaccessible to human operators and pave the way to truly personalized management of oncological patients. Although a significant proportion of currently available artificial intelligence solutions belong to basic and translational cancer imaging research, their progressive transfer to clinical routine is imminent, contributing to the development of a personalized approach in oncology. We thereby review the main applications of artificial intelligence in oncological imaging, describe the example of their successful integration into research and clinical practice, and highlight the challenges and future perspectives that will shape the field of oncological radiology.
Book review: Akhil Ranjan Dutta, Hindutva Regime in Assam: Saffron in the Rainbow and Nani Gopal Mahanta, Citizenship Debate over NRC & CAA: Assam and the Politics of History
Authors: Sengupta Papia 
Published: November 2022

Akhil Ranjan Dutta, Hindutva Regime in Assam: Saffron in the Rainbow. SAGE Publications. 2021. 329 pages. ₹1295. ISBN: 9789391370411. Nani Gopal Mahanta, Citizenship Debate over NRC & CAA: Assam and the Politics of History. SAGE Publications. 2021. 326 pages. ₹1395. ISBN: 9789391370299.
Changes in the Number of Public Health Nurses Employed in Local Governments in Japan During the Covid-19 Pandemic: A Cross-Sectional Study
Authors: Taira Kazuya , Hosokawa Rikuya , Shiomi Misa 
Published: November 2022

Introduction Prefectural public health centers in Japan conducted epidemiological surveys of all COVID-19 patients, which subsequently increased their workload as the infection rate increased. The survey was conducted by public health nurses (PHNs); therefore, an increase in their workload was expected. However, changes in the number of PHNs have not yet been examined. This study focused on recruiting PHNs to local governments in Japan during the COVID-19 pandemic. Methods This cross-sectional study of 150 local government public health centers was conducted from November to December 2021. The survey items included the number of full-time and part-time PHNs, number of PHNs who resigned or retired from the job, and number of PHNs recruitment examinations conducted between 2017 and 2021. For all variables, the mean, standard deviation, and minimum and maximum values for each municipality and year were calculated, and a one-way analysis of variance was performed. Conclusion The response rate of the questionnaires was 54.0% (81/150). The change in the employment status of PHNs from 2019 to 2020 was not statistically significant in 2020, which was the COVID-19 outbreak year. However, the number of full-time PHNs increased by 2.6, while part-time PHNs almost doubled from 5.2 ± 8.3 to 10.8 ± 9.6 ( p = .61) for prefectures, from 13.6 ± 13.1 to 21.5 ± 34.8 ( p = .23) for cities, and from 16.8 ± 26.8 to 52.3 ± 132.5 ( p = .70) for wards. The survey revealed that since the COVID-19 pandemic, the ratio of part-time to full-time PHNs significantly increased. Current status reports of public health centers will encourage political decisions and research on the factors necessary to balance the supply and demand of full-time PHNs.
Thermal evolution of a Variscan syn-orogenic intracontinental basin (Servoz basin, Western Alps): RSCM geothermometry and geochronology
Authors: Vanardois Jonas , Lahfid Abdeltif , Trap Pierre , Lacroix Brice , Roger Françoise , Guillou-Frottier Laurent , Marquer Didier , Paquette Jean-Louis , Melleton Jérémie 
Published: November 2022

AbstractThe Variscan basement of the Aiguilles-Rouges massif (Western Alps) exposes the Servoz syncline which consists of a metavolcano-sedimentary sequence composed of (i) a volcanic unit of unknown age and origin, (ii) Early Carboniferous sedimentary series affected by the Variscan orogeny and intruded by the Montées-Pélissier pluton, and (iii) a Late Carboniferous late-orogenic sedimentary sequence. We combined field investigations, Raman Spectroscopy on Carbonaceous Material geothermometry, and LA-ICPMS U-Th-Pb geochronology on zircon in order to reappraise the sedimentary sequence of the Servoz syncline. Our results allow us to identify three distinct sedimentary formations (F1, F2 and F3). The F1 formation is composed of metagreywackes, bimodal volcanic and magmatic rocks formed during basin opening at an early rifting stage (370–350 Ma) within a back-arc geodynamic setting. This extensional regime was responsible for a high thermal event recorded by a ca. 115 °C/km apparent geothermal gradient. Local anatexis of the basement rocks under the basin is dated at 351 ± 5 Ma. Basin inversion occurred between 350 and 330 Ma in response to oblique collision, with the development of large-scale dextral shear zones and syn-kinematic 340–330 Ma granite intrusions. Subsequent dextral transtension was responsible for the opening of a pull-apart basin between ca. 330 and 310 Ma with the deposition of the F2 phyllite formation that was later deformed by the ongoing dextral transcurrent Variscan tectonics at temperatures between 200 and 350 °C. Finally, the F3 terrigenous sedimentary rocks deposited at ca. 310–290 Ma in a late-orogenic extensional basin. The Alpine-related tectonic event overprinted all the temperatures below 350 °C. Although similar basins have been recognized in other External Crystalline Massifs of the Alps, the Servoz syncline is the first example that allows a major part of the polyphase tectonic evolution, since the early stages of the Devonian, to be recognized. Comparison with similar back-arc basins from the French Central massif, the Vosges massif and the Bohemian massif suggests that the External Crystalline Massifs initially belonged to the Moldanubian hinterlands of the Variscan belt.
Design of Passive Constant-Force End-Effector for Robotic Polishing of Optical Reflective Mirrors
Authors: Zhang Jian , Zhao Liangxiao , Li Lingling , Ma Fulei , Chen Guimin 
Published: November 2022

AbstractPolishing plays an indispensable role in optical processing, especially for large-aperture optical reflective mirrors with freeform surfaces. Robotic polishing requires effective control of the contact force between the robot and the mirror during processing. In order to maintain a constant contact force during polishing, traditional polishing robots rely on closed-loop control of air cylinders, whose performances heavily rely on high-fidelity force sensing and real-time control. This paper proposes to employ a compliant constant-force mechanism in the end-effector of a polishing robot to passively maintain a constant force between the robot and the mirror, thus eliminating the requirement for force sensing and closed-loop control. The compliant constant force mechanism utilizing the second bending mode of fixed-guided compliant beams is adopted and elaborated for the passive end-effector. An end-effector providing a constant contact force of 40 N is designed and prototyped. The polishing experiment shows that the passive constant-force end-effector provides stable contact force between the robot and the mirror with fluctuation within 3.43 N, and achieves RMS (Root Mean Square) lower than λ/10 (λ = 632.8 nm) of the polished surface of the large-aperture optical reflective mirror. It is concluded that the constant-force compliant mechanism provides a low-cost and reliable solution for force control in robotic polishing.
A rare mutation (p.F149del) of the NT5C3A gene is associated with pyrimidine 5′-nucleotidase deficiency
Authors: Bogusławska Dżamila M. , Skulski Michał , Bartoszewski Rafał , Machnicka Beata , Heger Elżbieta , Kuliczkowski Kazimierz , Sikorski Aleksander F. 
Published: November 2022

AbstractPyrimidine 5′-nucleotidase deficiency is a rare erythrocyte enzymopathy. Here we report two cases of hemolytic anemia in brothers of Polish origin that are associated with a very rare mutation. Heterozygous deletion in the NT5C3A gene (c.444_446delGTT), inherited most likely from their asymptomatic mother, resulted in a single amino acid residue deletion (p.F149del) in cytosolic pyrimidine 5′-nucleotidase. However, only the mutated transcript was present in the reticulocyte transcriptome of both patients. Only residual activity of pyrimidine 5′-nucleotidase in the brothers’ erythrocytes could be observed when compared with the controls, including their asymptomatic father and sister. Western blot showed no sign of the presence of 5′-nucleotidase protein in the erythrocytes of both studied patients. The 2.5-fold reduction of the purine/pyrimidine ratio observed only in the brothers’ erythrocytes confirms the correlation of the results of molecular analysis, including whole-exome sequencing, with the phenotype of the pyrimidine 5′-nucleotidase deficiency. Altogether, our results may substantiate the hypothesis of the heterogeneity of the molecular basis of the defect involving both the mutation presented here and negative regulation of expression of the “normal” allele.
A randomized, controlled trial of ZYN002 cannabidiol transdermal gel in children and adolescents with fragile X syndrome (CONNECT-FX)
Authors: Berry-Kravis Elizabeth , Hagerman Randi , Budimirovic Dejan , Erickson Craig , Heussler Helen , Tartaglia Nicole , Cohen Jonathan , Tassone Flora , Dobbins Thomas , Merikle Elizabeth , Sebree Terri , Tich Nancy , Palumbo Joseph M. , O’Quinn Stephen 
Published: November 2022

Abstract
Background
Fragile X syndrome (FXS) is associated with dysregulated endocannabinoid signaling and may therefore respond to cannabidiol therapy.

Design
CONNECT-FX was a double-blind, randomized phase 3 trial assessing efficacy and safety of ZYN002, transdermal cannabidiol gel, for the treatment of behavioral symptoms in children and adolescents with FXS.

Methods
Patients were randomized to 12 weeks of ZYN002 (250 mg or 500 mg daily [weight-based]) or placebo, as add-on to standard of care. The primary endpoint assessed change in social avoidance (SA) measured by the Aberrant Behavior Checklist–Community Edition FXS (ABC-CFXS) SA subscale in a full cohort of patients with a FXS full mutation, regardless of the FMR1 methylation status. Ad hoc analyses assessed efficacy in patients with ≥ 90% and 100% methylation of the promoter region of the FMR1 gene, in whom FMR1 gene silencing is most likely.

Results
A total of 212 patients, mean age 9.7 years, 75% males, were enrolled. A total of 169 (79.7%) patients presented with ≥ 90% methylation of the FMR1 promoter and full mutation of FMR1. Although statistical significance for the primary endpoint was not achieved in the full cohort, significant improvement was demonstrated in patients with ≥ 90% methylation of FMR1 (nominal P = 0.020). This group also achieved statistically significant improvements in Caregiver Global Impression‐Change in SA and isolation, irritable and disruptive behaviors, and social interactions (nominal P-values: P = 0.038, P = 0.028, and P = 0.002). Similar results were seen in patients with 100% methylation of FMR1. ZYN002 was safe and well tolerated. All treatment-emergent adverse events (TEAEs) were mild or moderate. The most common treatment-related TEAE was application site pain (ZYN002: 6.4%; placebo: 1.0%).

Conclusions
In CONNECT-FX, ZYN002 was well tolerated in patients with FXS and demonstrated evidence of efficacy with a favorable benefit risk relationship in patients with ≥ 90% methylation of the FMR1 gene, in whom gene silencing is most likely, and the impact of FXS is typically most severe.

Trial registration
The CONNECT-FX trial is registered on Clinicaltrials.gov (NCT03614663).
A graph neural network framework for mapping histological topology in oral mucosal tissue
Authors: Nair Aravind , Arvidsson Helena , Gatica V. Jorge E. , Tudzarovski Nikolce , Meinke Karl , Sugars Rachael. V 
Published: November 2022

Abstract
Background
Histological feature representation is advantageous for computer aided diagnosis (CAD) and disease classification when using predictive techniques based on machine learning. Explicit feature representations in computer tissue models can assist explainability of machine learning predictions. Different approaches to feature representation within digital tissue images have been proposed. Cell-graphs have been demonstrated to provide precise and general constructs that can model both low- and high-level features. The basement membrane is high-level tissue architecture, and interactions across the basement membrane are involved in multiple disease processes. Thus, the basement membrane is an important histological feature to study from a cell-graph and machine learning perspective.

Results
We present a two stage machine learning pipeline for generating a cell-graph from a digital H &E stained tissue image. Using a combination of convolutional neural networks for visual analysis and graph neural networks exploiting node and edge labels for topological analysis, the pipeline is shown to predict both low- and high-level histological features in oral mucosal tissue with good accuracy.

Conclusions
Convolutional and graph neural networks are complementary technologies for learning, representing and predicting local and global histological features employing node and edge labels. Their combination is potentially widely applicable in histopathology image analysis and can enhance explainability in CAD tools for disease prediction.
What do we want to get out of this? a critical interpretive synthesis of the value of process evaluations, with a practical planning framework
Authors: French Caroline , Dowrick Anna , Fudge Nina , Pinnock Hilary , Taylor Stephanie J. C. 
Published: November 2022

AbstractBackgroundProcess evaluations aim to understand how complex interventions bring about outcomes by examining intervention mechanisms, implementation, and context. While much attention has been paid to the methodology of process evaluations in health research, the value of process evaluations has received less critical attention. We aimed to unpack how value is conceptualised in process evaluations by identifying and critically analysing 1) how process evaluations may create value and 2) what kind of value they may create.MethodsWe systematically searched for and identified published literature on process evaluation, including guidance, opinion pieces, primary research, reviews, and discussion of methodological and practical issues.We conducted a critical interpretive synthesis and developed a practical planning framework.ResultsWe identified and included 147 literature items. From these we determined three ways in which process evaluations may create value or negative consequences: 1) through the socio-technical processes of ‘doing’ the process evaluation, 2) through the features/qualities of process evaluation knowledge, and 3) through using process evaluation knowledge. We identified 15 value themes. We also found that value varies according to the characteristics of individual process evaluations, and is subjective and context dependent.ConclusionThe concept of value in process evaluations is complex and multi-faceted. Stakeholders in different contexts may have very different expectations of process evaluations and the value that can and should be obtained from them. We propose a planning framework to support an open and transparent process to plan and create value from process evaluations and negotiate trade-offs. This will support the development of joint solutions and, ultimately, generate more value from process evaluations to all.
Virtual family physician care during COVID-19: a mixed methods study using health administrative data and qualitative interviews
Authors: Ryan Bridget L. , Brown Judith Belle , Freeman Thomas R. , Richard Lucie , Stewart Moira , Meredith Leslie , Choi Yun-Hee , He Jennifer Wei , Cejic Sonny , Thompson Keith , Reichert Sonja , Shariff Salimah Z. , Booth Richard , Terry Amanda L. , Mathews Maria 
Published: November 2022

Abstract
Background
The onset of the COVID-19 pandemic necessitated a rapid shift in primary health care from predominantly in-person to high volumes of virtual care. The pandemic afforded the opportunity to conduct a deep regional examination of virtual care by family physicians in London and Middlesex County, Ontario, Canada that would inform the foundation for virtual care in our region post-pandemic. Objectives: (1) to determine volumes of in-person and virtual family physicians visits and characteristics of the family physicians and patients using them during the early COVID-19 pandemic; (2) to determine how virtual visit volumes changed over the pandemic, compared to in-person; and (3) to explore family physicians’ experience in virtual visit adoption and implementation.

Methods
We conducted a concurrent mixed-methods study of family physicians from March to October 2020. The quantitative component examined mean weekly number of total, in-person and virtual visits using health administrative data. Differences in outcomes according to physician and practice characteristics for pandemic periods were compared to pre-pandemic. The qualitative study employed Constructivist Grounded Theory, conducting semi-structured family physicians interviews; analyzing data iteratively using constant comparative analysis. We mapped themes from the qualitative analysis to quantitative findings.

Results
Initial volumes of patients decreased, driven by fewer in-person visits. Virtual visit volumes increased dramatically; family physicians described using telephone almost entirely. Rural family physicians reported video connectivity issues. By early second wave, total family physician visit volume returned to pre-pandemic volumes. In-person visits increased substantially; family physicians reported this happened because previously scarce personal protective equipment became available. Patients seen during the pandemic were older, sicker, and more materially deprived.

Conclusion
These results can inform the future of virtual family physician care including the importance of continued virtual care compensation, the need for equitable family physician payment models, and the need to attend to equity for vulnerable patients. Given the move to virtual care was primarily a move to telephone care, the modality of care delivery that is acceptable to both family physicians and their patients must be considered.
Sex differences in the association of physical activity levels and vitamin D with obesity, sarcopenia, and sarcopenic obesity: a cross-sectional study
Authors: Jia Shuli , Zhao Wanyu , Hu Fengjuan , Zhao Yunli , Ge Meiling , Xia Xin , Yue Jirong , Dong Birong 
Published: November 2022

Abstract
Background
The relationship between vitamin D and sarcopenia was inconsistent between men and women. Physical activity (PA) may interact with vitamin D on sarcopenia. However, the sex-specific relationships of vitamin D, PA and sarcopenia have yet elucidated. We aimed to examine the sex differences in the relation between vitamin D status, PA levels, obesity and sarcopenia in community-dwelling middle-aged and older adults, as well as whether vitamin D status is a modifier in the relationship between PA and sarcopenia.

Methods
The current study was a cross-sectional study based on the baseline survey of the West China Health and Aging Trend (WCHAT) study. A total of 3713 participants aged ≥ 50y were included in our study. Sarcopenia was defined according to the Asian Working Group for Sarcopenia (AWGS) 2019 consensus. Obesity was defined by body mass index (BMI) (≥ 28 kg/m2) and body fat mass percentage (≥ 60th percentile in each sex group). 25-hydroxyvitamin D was measured by chemiluminescent microparticle immunoassay and PA was evaluated by a validated China Leisure Time Physical Activity Questionnaire (CLTPAQ). Multinomial logistic regression was performed to examine the relationship between PA, vitamin D and sarcopenia and obesity.

Results
Low PA was significantly associated with higher odds of sarcopenia in women only (OR = 1.70,95%CI:1.18,2.46, p < 0.01). Vitamin D deficiency was only associated with sarcopenia in men (OR = 1.85,95%CI: 1.27,2.69, p < 0.01). Low PA was significantly associated with obesity, sarcopenia, and sarcopenic obesity only in participants with serum 25(OH)D < 20 ng/ml.

Conclusions
The role of vitamin D and PA in obesity and sarcopenia was different between men and women, and the relationship between PA and sarcopenia was modified by serum vitamin D status. These findings highlighted the need to supplement vitamin D in individuals with physical inactivity and provide different interventions strategies to sarcopenia in men and women.

Trial registration
Clinical trial number: ChiCTR1800018895.