bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Physical Activity Interventions on Return to Work After a Cancer Diagnosis: A Systematic Review and Meta-analysis
Authors: Wilson Têtê Norbert , Nambiema Aboubakari , Porro Bertrand , Descatha Alexis , Aublet-Cuvelier Agnès , Evanoff Bradley , Roquelaure Yves 
Published: July 2022

Abstract
Purpose The aim of this study was to assess the effectiveness of physical activity (PA) interventions on return to work (RTW) in cancer survivors, compared to usual care, and to determine the dose of PA needed to improve this outcome. Methods A systematic review and meta-analysis were conducted according to PRISMA guidelines. Six electronic databases including PubMed, Embase, Web of Science, CENTRAL, PsycINFO, and Scopus were searched to identify studies, and completed by a search of grey literature and health organization websites. Two authors performed screening, selection, and data extraction independently. Study and intervention characteristics were extracted and summarized. Pooled risk ratio (RR) was estimated using a weight random-effects model with 95% confidence intervals (CIs). Results A total of 2655 records were identified, of which 8 intervention studies were included. The sample size of the included studies varied between 41 and 240, giving a total of 1087 participants aged between 18 and 75 years. Compared with usual care, PA interventions had a significant positive effect on RTW among cancer survivors with a pooled RR of 1.29 (95% CI 1.17, 1.42). We found that PA interventions (aerobic and resistance exercises) with an exercise dose between 7.6 METs.h/week and 15 METs.h/week, consisting in 50–60 min per session of moderate to vigorous physical exercise, twice a week seems relevant in improving RTW. Conclusions Our results showed, with moderate quality evidence that PA interventions are more effective than usual care in increasing the rate of RTW in cancer survivors.

Systematic Review Registration
PROSPERO Registration Number, CRD42020203614.
Suppression of wind turbine noise from seismological data using nonlinear thresholding and denoising autoencoder
Authors: Heuel Janis , Friederich Wolfgang 
Published: July 2022

AbstractSeismologists found a significant deterioration in station quality after installation of wind turbines (WTs), which led to conflicts between WT operators and seismic services. We compare different techniques to reduce the disturbing signals from WTs at seismological stations by selection of an affected station. WT noise and earthquake signals have overlapping frequency bands, and thus spectral filtering cannot be used. As a first method, we apply the continuous wavelet transform on our data to obtain a time-scale representation. From this representation, we estimate a noise threshold function either from noise before the theoretical P-arrival or using a noise signal from the past with similar ground velocity conditions at the surrounding WTs. As a second method, we use a denoising autoencoder (DAE) that learns mapping functions to distinguish between noise and signal. In our tests, the threshold function performs well when the event is visible in the raw or spectral filtered data, but it fails when WT noise dominates. The use of the threshold function and pre-noise can be applied immediately to real-time data and has low computational cost. Using a noise model from our prerecorded database at the seismological station does not improve the result and is more time consuming. In contrast, the DAE is able to remove WT noise even when the event is completely covered by noise. However, the DAE must be trained with typical noise samples and high signal-to-noise ratio events to distinguish between signal and interfering noise.
SOX9 is a target of miR-134-3p and miR-224-3p in breast cancer cell lines
Authors: Chao Tsu-Yang , Kordaß Theresa , Osen Wolfram , Eichmüller Stefan B. 
Published: July 2022

AbstractThe transcription factor SOX9 represents an important mediator of breast cancer progression. miRNAs are small non-coding RNAs inhibiting translation of target genes upon interaction with the 3′-UTR region of respective mRNA molecules. Deregulated miRNA expression is involved in hallmarks of cancer like sustained proliferation and inhibition of apoptosis. Here, we investigated the miRNA-mediated regulation of SOX9 expression in two breast cancer cell lines, thereby providing further insights into cellular mechanisms driving breast cancer progression. The modulating effects of miR-134-3p, miR-224-3p, and miR-6859-3p on SOX9 expression were analyzed by qPCR and Western blot in human MDA-MB-231 breast cancer cells. Direct binding of the above-mentioned miRNAs to the SOX9 3′-UTR was assessed by luciferase reporter assays and site-directed mutagenesis. Expression levels of the investigated miRNAs in tumor samples versus healthy tissues were analyzed in silico using publicly available databases. Transfection of miR-134-3p, miR-224-3p, or miR-6859-3p reduced SOX9 expression on mRNA and protein level. Reporter assays proved direct binding of miR-134-3p and miR-224-3p to the SOX9 3′-UTR in MDA-MB-231 and MCF-7 cells. Expression analysis performed in silico revealed reduced expression of both miRNAs in breast cancer tissues. We describe three novel miRNAs targeting SOX9 in human breast cancer cell lines. Among them miR-134-2p and miR-224-3p might act as tumor suppressors, whose down-regulation induces elevated SOX9 levels thereby promoting breast cancer progression.
Unraveling Reactionary Care: The Experience of Mother-Caregivers of Adults with Severe Mental Disorders in Catalonia
Authors: Alegre-Agís Elisa , García-Santesmases Andrea , Pié-Balaguer Asun , Martínez-Hernáez Àngel , Bekele Deborah , Morales-Sáez Nicolás , Serrano-Miguel Mercedes 
Published: July 2022

AbstractIn most Mediterranean countries, people diagnosed with severe mental disorders (SMDs) are typically cared for by the mother, causing a significant burden on people in this family role. Based on a broader mental health participatory action and qualitative research carried out in Catalonia (Spain) of 12 in-depth interviews and 3 focus groups, this article analyses the mother-caregivers’ experience in the domestic space. The results show that patients and caregivers are engaged in a relationship of “nested dependencies”, which create social isolation. This produces the conditions of “reactionary care”, practices that limit the autonomy of those affected and that reproduce forms of disciplinary psychiatric institutions. We conclude that both institutional violence derived from economic rationality and that which stems from the gender mandate feed off each other into the domestic sphere. This research argues for placing care at the center of clinical practice and shows the need to consider the structural forces shaping it.
A cool spot in a biodiversity hotspot: why do tall Eucalyptus forests in Southwest Australia exhibit low diversity?
Authors: Zhou Xue Meng , Ranathunge Kosala , Cambridge Marion L. , Dixon Kingsley W. , Hayes Patrick E. , Nikolic Miroslav , Shen Qi , Zhong Hongtao , Lambers Hans 
Published: July 2022

Abstract
Background and aims
Southwest Australia is a biodiversity hotspot, with greatest plant species diversity on the most severely phosphorus (P)-impoverished soils. Here, non-mycorrhizal species with highly-effective carboxylate-releasing P-acquisition strategies coexist with mycorrhizal species that are less effective at accessing P on these soils. Non-mycorrhizal carboxylate-releasing species facilitate P acquisition of mycorrhizal neighbours that are better defended against pathogens. In the Southwest Australian Biodiversity Hotspot, there are also ‘cool spots’ of low-diversity tall mycorrhizal Eucalyptus communities on P-impoverished soils. These Eucalyptus trees obviously do not require facilitation of their P acquisition by carboxylate-releasing neighbours, because these are only a minor component of the low-diversity communities. We hypothesised that in low-diversity tall Eucalyptus forests, mycorrhizal species release carboxylates to acquire P. Thus, they would not depend on facilitation, and must be strong competitors. However, because they would not depend on external mycorrhizal hyphae to acquire P, they would also not be able to access soil organic nitrogen (N), for which they would need external hyphae.

Methods
Since carboxylates not only mobilise P, but also manganese (Mn), we used leaf Mn concentrations ([Mn]) in the natural habitat to proxy rhizosphere carboxylates. To verify this proxy, we also measured carboxylate exudation of targeted species with high leaf [Mn] using seedlings grown in low-P nutrient solutions.

Results
Using these complementary approaches, we confirmed our hypothesis that dominant Eucalyptus species in ‘cool spots’ release carboxylates. Since mineralisation of organic N is associated with fractionation of N, enriching organic N with 15N while nitrate is depleted in 15N, we measured the stable N isotope composition of leaf material. The results show that dominant Eucalyptus species did not access organic N, despite being ectomycorrhizal.

Conclusions
The low diversity of tall Eucalyptus forests in southwest Australia can be explained by dominant mycorrhizal species exhibiting a carboxylate-releasing strategy. The tall eucalypts are therefore strong competitors that do not require facilitation, but also do not access organic N.
Patient-reported outcome measures for assessing health-related quality of life in people with type 2 diabetes: A systematic review
Authors: Langendoen-Gort Marlous , Groeneveld Lenka , Prinsen Cecilia A. C. , Beulens Joline W. , Elders Petra J. M. , Halperin Ilana , Mukerji Geetha , Terwee Caroline B. , Rutters Femke 
Published: July 2022

AbstractPatient-Reported Outcome Measures (PROMs) are important tools to assess outcomes relevant to patients, with Health-Related Quality Of Life (HRQOL) as an important construct to be measured. Many different HRQOL PROMs are used in the type 2 diabetes field, however a complete overview of these PROMs is currently lacking. We therefore aimed to systematically describe and classify the content of all PROMs that have specifically been developed or validated to measure (aspects of) HRQOL in people with type 2 diabetes. A literature search was performed in PubMed and EMBASE until 31 December 2021. Studies on the development or validation of a PROM measuring HRQOL, or aspects of HRQOL, in people with type 2 diabetes were included. Title and abstract and full-text screening were conducted by two independent researchers and data extraction was performed independently by one of the researchers. Data were extracted on language in which the PROM was developed, target population, construct(s) being measured, names of (sub)scales and number of items per (sub)scale. In addition, all PROMs and subscales were classified according to specific aspects of HRQOL based on the Wilson & Cleary model (symptom status, functional status, general health perceptions) to aid researchers in PROM selection. In total 220 studies were identified that developed or validated PROMs that measure (aspects of) HRQOL in people with type 2 diabetes. Of the 116 unique HRQOL PROMs, 91 (of the subscales) measured symptom status, 60 measured functional status and 26 measured general health perceptions. In addition, 16 of the PROMs (subscales) measured global quality of life. 61 of the 116 PROMs (subscales) also include characteristics of the individual (e.g. aspects of personality, coping) or environment (e.g. social or financial support) and patient-reported experience measures (PREMs, e.g. measure of a patient's perception of their personal experience of the healthcare they have received, e.g. treatment satisfaction), which are not part of the HRQOL construct. Only 9 of the 116 PROMs measure all aspects of HRQOL based on the Wilson & Cleary model. Finally, 8 of the 116 PROMs stating to measure HRQOL, measured no HRQOL construct. In conclusion, a large number of PROMs are available for people with type 2 diabetes, which intend to measure (aspects of) HRQOL. These PROMs measure a large variety of (sub)constructs, which are not all HRQOL constructs, with a small amount of PROMs not measuring HRQOL at all. There is a need for consensus on which aspects of HRQOL should be measured in people with type 2 diabetes and which PROMs to use in research and daily practice. PROSPERO: CRD42017071012. COMET database:http://www.comet-initiative.org/studies/details/956.
Academic self-efficacy, self-esteem, and grit in higher online education: Consistency of interests predicts academic success
Authors: Neroni Joyce , Meijs Celeste , Kirschner Paul A. , Xu Kate M. , de Groot Renate H. M. 
Published: July 2022

AbstractAcademic self-efficacy, self-esteem, and grit (i.e., perseverance of effort and consistency of interests) have all separately shown to predict academic success within traditional education. In higher online education, information on these relationships is lacking, while this group of learners is growing in size and importance. We therefore investigated the total as well as the unique predictive value of academic self-efficacy, self-esteem, and grit on academic success in higher online education. Moreover, mediation effects were investigated. Students of a higher online education university in the Netherlands participated (N = 2027, age 18–80 years) in this observational study. Participants filled out online questionnaires on the variables of interest and potential confounding variables at baseline. Academic success was measured objectively through information provided by the exam registration office and operationalized in three variables: exam attempt, study progress, and academic performance. Logistic regression analyses showed that consistency of interests significantly predicted exam attempt (B = .43, p < .001). Generalized multiple linear regression analyses with negative binomial distribution showed that consistency of interests was a significant predictor of study progress (B = .16, p < .001). Mixed model analyses revealed no significant predictors for academic performance (ps > .06). The fact that of our three predictors solely consistency of interests was found to be predictive for academic success indicates that online educational institutes should pay attention to consistency of interests of their students to improve the academic success rates.
Ferrofluid Impregnation Efficiency and Its Spatial Variability in Natural and Synthetic Porous Media: Implications for Magnetic Pore Fabric Studies
Authors: Pugnetti Michele , Zhou Yi , Biedermann Andrea R. 
Published: July 2022

AbstractMagnetic pore fabrics (MPF) are an efficient way to characterize pore space anisotropy, i.e., the average pore shape and orientation. They are determined by impregnating rocks with ferrofluid and then measuring their magnetic anisotropy. Obtaining even impregnation of the entire pore space is key for reliable results, and a major challenge in MPF studies. Here, impregnation efficiency and its spatial variability are systematically tested for natural (wood, rock) and synthetic (gel) samples, using oil- and water-based ferrofluids, and comparing various impregnation methods: percolation, standard vacuum impregnation, flowthrough vacuum impregnation, immersion, diffusion, and diffusion assisted by magnetic forcing. Seemingly best impregnation was achieved by standard vacuum impregnation and oil-based ferrofluid (76%), and percolation (53%) on rock samples; however, sub-sampling revealed inhomogeneous distribution of the fluid within the samples. Flowthrough vacuum impregnation yielded slightly lower bulk impregnation efficiencies, but more homogeneous distribution of the fluid. Magnetically assisted diffusion led to faster impregnation in gel samples, but appeared to be hindered in rocks by particle aggregation. This suggests that processes other than the mechanical transport of nanoparticles in the pore space need to be taken into account, including potential interactions between the ferrofluid and rock, particle aggregation and filtering. Our results indicate that bulk measurements are not sufficient to assess impregnation efficiency. Since spatial variation of impregnation efficiency may affect MPF orientation, degree and shape, impregnation efficiency should be tested on sub-samples prior to MPF interpretation.
Seasonal pattern in elderly hospitalized with acute kidney injury: a retrospective nationwide study in Italy
Authors: De Giorgi Alfredo , Storari Alda , Rodríguez-Muñoz Pedro Manuel , Cappadona Rosaria , Lamberti Nicola , Manfredini Fabio , López-Soto Pablo Jesús , Manfredini Roberto , Fabbian Fabio 
Published: July 2022

Abstract
Purpose
Acute kidney injury (AKI) frequently complicates hospitalization and is associated with in-hospital mortality (IHM). It has been reported a seasonal trend in different clinical conditions. The aim of this study was to evaluate the possible relationship between seasons of the year and IHM in elderly hospitalized patients with AKI.

Methods
We selected all admissions complicated by AKI between 2000 and 2015 recorded in the Italian National Hospital Database. ICD-9-CM code 584.xx identified subjects with age ≥ 65 years and age, sex, comorbidity burden, need of dialysis treatment and IHM were compared in hospitalizations recorded during the four seasons. Moreover, we plotted the AKI observed/expected ratio and percentage of mortality during the study period.

Results
We evaluated 759,720 AKI hospitalizations (mean age 80.5 ± 7.8 years, 52.2% males). Patients hospitalized with AKI during winter months had higher age, prevalence of dialysis-dependent AKI, and number of deceased patients. In whole population IHM was higher in winter and lower in summer, while the AKI observed/expected ratio demonstrated two peaks, one in summer and one in winter. Logistic regression analysis demonstrated that parameters such as age, autumn, winter, comorbidity burden were positively associated with IHM.

Conclusion
We conclude that a seasonality exists in AKI, however, relationship between seasons and AKI could vary depending on the aspects considered. Both autumn and winter months are independent risk factors for IHM in patients with AKI regardless of age, sex and comorbidity burden. On the contrary, summer time reduces the risk of death during hospitalizations with AKI.
Hypoglossal nerve stimulation versus positive airway pressure therapy for obstructive sleep apnea
Authors: Heiser Clemens , Steffen Armin , Strollo Patrick J. , Giaie-Miniet Claire , Vanderveken Olivier M. , Hofauer Benedikt 
Published: July 2022

Abstract
Purpose
Hypoglossal nerve stimulation (HNS) has been shown to treat obstructive sleep apnea (OSA) effectively. The aim of this study was to compare HNS with positive airway pressure (PAP) treatment regarding outcome parameters: (1) sleepiness, (2) apnea–hypopnea index (AHI), and (3) effectiveness.

Methods
Propensity score matching with nearest neighbor algorithm was used to compare outcomes of HNS and PAP therapy in a real-world setting. Data were collected at baseline and 12 months after initiating OSA treatment including demographics, Epworth Sleepiness Scale (ESS), AHI, and objective adherence data. To account for overall treatment efficacy, the mean disease alleviation (MDA) was calculated.

Results
Of 227 patients who received treatment consecutively, 126 could be matched 1:1 with regard to age, body mass index, and AHI. After matching, no statistically significant differences between the groups were found. A clinically important symptom improvement was seen at 12 months in both cohorts, though there was a greater difference in ESS improvement in patients treated with HNS (8.0 ± 5.1 points vs. 3.9 ± 6.8 points; p = 0.042). In both groups, mean posttreatment AHI was significantly reduced (HNS: 8.1 ± 6.3/h; PAP: 6.6 ± 8.0/h; p < 0.001). Adherence after 12 months among patients treated with HNS was higher than in those receiving PAP therapy (5.0 ± 2.6 h/night; 4.0 ± 2.1 h/night) but not with statistical significance. Overall effectiveness calculated with the MDA was 59% in patients treated with HNS compared to 51% receiving PAP.

Conclusion
Patients treated with HNS therapy had significantly greater improvements in daytime sleepiness compared to PAP therapy, while the mean reduction of AHI and overall effectiveness were comparable for both treatments.

Trial registration
ClinicalTrial.gov Identifier: NCT03756805.
Characterization of ectomycorrhizal fungal communities associated with tree species on an iron tailings deposit undergoing restoration
Authors: Zhu Wenxu , Ding Changjun , Zhu Keye , Zhang Weixi , Liang Dejun , Wang XiaoJiang , Li Aiping , Su Xiaohua 
Published: July 2022

AbstractVegetation restoration is an effective method to improve the ecological environment of mine tailings, which has a profound impact on the potential ecological functions of soil fungal communities; yet, little is known about its beneficial effect on soil ectomycorrhizal fungal community. In this study, the responses of soil characteristics and soil ectomycorrhizal fungal community diversity and structure to different revegetation, as well as the contribution of soil factors to soil ectomycorrhizal community were investigated in Liaoning Province, China. As we anticipated, the presence of vegetation significantly improved most soil properties we studied. What’s more, compared to Korean pine (Pinus koraiensis Sieb. et Zucc.), Chinese poplar (Populus simonii Carr), and black locust (Robinia pseudoacacia L) could better improve soil total carbon, total nitrogen, total phosphorus, and available phosphorus. In addition, soil ectomycorrhizal fungal community diversity in black locust was greater than Korean pine and Populus simonii. Nonmetric multidimensional scaling analyses indicated that soil ectomycorrhizal community significantly differed depending on different revegetation types. Thus, these results indicated that black locust could be a suitable species for the revegetation of iron mine tailings. The study provided theoretical basis for ecological restoration of iron mine tailings using local plant species.
Synthesis of new Cr2O3/Fe2O3/glass composites from industrial wastes; from undesired to advanced optical products
Authors: Besisa Dina H. A. , Mohamed Hanan H. , Ewais Emad M. M. , Ahmed Yasser M. Z. , Amin Amira M. M. 
Published: July 2022

AbstractFor the tendency toward cleaner production and safe conversion of undesired toxic wastes to highly priced advanced products, this work introduces new ceramics/glass composites of Cr2O3/Fe2O3/lead silicate glass (LSG) from industrial LSG wastes. Both chromia Cr2O3 and hematite Fe2O3 ceramics are added equally to the LSG wastes with different percentages (10, 20, and 30 wt.%) via the pressureless sintering method. The competitiveness of this work is dependent on the conversion of undesired waste materials into advanced/smart optical materials with a low cost and an environmentally friendly method. Hence, the influence of both Cr2O3 and Fe2O3 additions on the behavior and the different characteristics of the lead silicate wastes are comprehensively investigated. Evaluation of the final ceramics/glass composites was achieved through their phase composition, microstructure, optical, and magnetic characteristics. The results verified that the insertion of both chromia and hematite together into the glass waste had a key role in improving its morphological properties and optical and magnetic behaviors. Composite with 30% of Cr2O3/Fe2O3 gave the highest optical absorbance of 90%, the lowest and best band gap energy of 1.68 ev, and the highest refractive index of 2.85. Also, it recorded the best magnetic behavior with the highest saturation magnetization of 139.700 × 10−2A m2 kg−1 and the best coercivity of 190.0 Oe. These findings confirmed the successful clean conversion of the hazardous lead silicate waste into advanced products with promising optoelectronic characteristics.
Graphical abstract