bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of two additional circumbinary planets around Kepler-451
Authors: Esmer Ekrem Murat , Baştürk Özgür , Selam Selim Osman , Aliş Sinan 
Published: February 2022

ABSTRACT
We announce the detection of two new planetary-mass companions around Kepler-451 binary system in addition to the one detected previously based on eclipse timing variation analysis. We found that an inner planet with 43 d period with a minimum mass of 1.76 Mjup and an outer one with a ∼1800 d orbital period with a minimum mass of 1.61 Mjup can explain the periodic variations in the residuals of the one-planet fit of the eclipse timings. We updated the orbital period of the middle planet as 406 d, and determined its eccentricity as 0.33. The newly discovered outer planet is also on an eccentric orbit (0.29), while the innermost planet was assumed to have a circular orbit. All three Jovian planets have similar masses, and our dynamical stability test yields that the system is stable.
The star formation burstiness and ionizing efficiency of low-mass galaxies
Authors: Atek Hakim , Furtak Lukas J , Oesch Pascal , van Dokkum Pieter , Reddy Naveen , Contini Thierry , Illingworth Garth , Wilkins Stephen 
Published: February 2022

ABSTRACT
We investigate the burstiness of star formation and the ionizing efficiency of a large sample of galaxies at 0.7 &lt; z &lt; 1.5 using HST grism spectroscopy and deep ultraviolet (UV) imaging in the GOODS-N and GOODS-S fields. The star formation history (SFH) in these strong emission-line low-mass galaxies indicates an elevated star formation rate (SFR) based on the Hα emission line at a given stellar mass when compared to the standard main sequence. Moreover, when comparing the Hα and UV SFR indicators, we find that an excess in SFRHα compared to SFRUV is preferentially observed in lower mass galaxies below 109 M⊙, which are also the highest-EW galaxies. These findings suggest that the burstiness parameters of these strong emission-line galaxies may differ from those inferred from hydrodynamical simulations and previous observations. For instance, a larger burstiness duty cycle would explain the observed SFRHα excess. We also estimate the ionizing photon production efficiency ξion, finding a median value of log(ξion/erg−1 Hz) = 24.80 ± 0.26 when adopting a Galactic dust correction for Hα and an SMC one for the stellar component. We observe an increase of ξion with redshift, further confirming similar results at higher redshifts. We also find that ξion is strongly correlated with EWHα, which provides an approach for deriving ξion in early galaxies. We observe that lower mass, lower luminosity galaxies have a higher ξion. Overall, these results provide further support for faint galaxies playing a major role in the reionization of the Universe.
Emergence of galactic morphologies at cosmic dawn: input from numerical modelling
Authors: Bi Da , Shlosman Isaac , Romano-Díaz Emilio 
Published: February 2022

ABSTRACTWe employ a series of high-resolution zoom-in cosmological simulations to analyse the emerging morphology of main galaxies in dark matter haloes at z ≳ 2. We choose haloes of similar masses, ${\rm log}\, M_{\rm vir}/{\rm M_\odot }\sim 11.65\pm 0.05$, at the target zf = 6, 4, and 2. The rationale for this choice allows us to analyse how the different growth rate in these haloes propagates down to galaxy scales, affecting their basic parameters. Halos were embedded in high/low overdensity regions, and two versions of a galactic wind feedback were employed. Our main results are: (1) Although our galaxies evolve in different epochs, their global parameters remain within narrow range. Their morphology, kinematics, and stellar populations differ substantially, yet all host sub-kpc stellar bars; (2) The star formation rates appear higher for larger zf; (3) Bulges and stellar spheroids were separated by stellar kinematics, discy bulges were revealed using the Sersic method and photometry.The bulge-to-total mass ratios appear independent of the last merger time for all zf. The spheroid-to-total mas ratios lie within ∼0.5–0.8; (4) The synthetic redshifted, pixelized, and PSF-degraded JWST images allow detection of stellar discs at all zf. (5) Based on the kinematic decomposition, rotational support in discs depends on the feedback type, but increases with decreasing zf; (6) Finally, the ALMA images detect discs at all zf, but spiral structure is detectable in zf = 2 galaxies. Moreover, galaxies follow the Tully–Fisher relation, being separated only by the galactic wind feedback.
Kidney health for all: bridging the gap in kidney health education and literacy
Authors: Langham Robyn G , Kalantar-Zadeh Kamyar , Bonner Ann , Balducci Alessandro , Hsiao Li-Li , Kumaraswami Latha A , Laffin Paul , Liakopoulos Vassilios , Saadi Gamal , Tantisattamo Ekamol , Ulasi Ifeoma , Lui Siu-Fai ,   The World Kidney Day Joint Steering Committee, Langham Robyn G , Kalantar–Zadeh Kamyar , Balducci Alessandro , Hsiao Li-Li , Kumaraswami Latha , Laffin Paul , Liakopoulos Vassilios , Saadi Gamal , Ulasi Ifeoma , Lui Siu-Fai 
Published: February 2022

ABSTRACT
The high burden of kidney disease, global disparities in kidney care and poor outcomes of kidney failure bring a concomitant growing burden to those affected, their families, caregivers and the community at large. Health literacy is the degree to which people and organizations have or equitably enable individuals to have the ability to find, understand and use information and services to make informed health-related decisions and actions for themselves and others. Rather than viewing health literacy as a patient deficit, improving health literacy largely rests with healthcare providers communicating and educating effectively in a co-designed partnership with those with kidney disease. For kidney policymakers, health literacy provides the imperative to shift organizations to a culture that places the person at the center of healthcare. The growing capability of and access to technology provides new opportunities to enhance education and awareness of kidney disease for all stakeholders. Advances in telecommunication, including social media platforms, can be leveraged to enhance people's and providers’ education; the World Kidney Day declares 2022 as the year of ‘Kidney Health for All’ to promote global teamwork in advancing strategies in bridging the gap in kidney health education and literacy. Kidney organizations should work toward shifting the patient-deficit health literacy narrative to that of being the responsibility of healthcare providers and health policymakers. By engaging in and supporting kidney health-centered policymaking, community health planning and health literacy approaches for all, the kidney communities strive to prevent kidney diseases and enable living well with kidney disease.
Cyclical signals from the labor market
Authors: Berger Tino , Boll Paul David , Morley James , Wong Benjamin 
Published: February 2022

AbstractWe consider which labor market variables are the most informative for estimating and nowcasting the US output gap using a multivariate trend-cycle decomposition. Although the unemployment rate clearly contains important cyclical information, it also appears to reflect more persistent movements related to labor force participation that could distort inferences about the output gap. Instead, we show that the alternative U-2 unemployment rate (job losers as a percentage of the labor force) provides a more purely cyclical indicator of labor market conditions. To a lesser extent, but consistent with a link of the output gap to real labor costs in a New Keynesian setting, we also find that average hourly earnings are informative about the output gap.
Pain Burden in the CASiRe International Cohort of Sickle Cell Patients: United States and Ghana
Authors: Zempsky William T , Yanaros Mary , Sayeem Mohammed , Boruchov Donna , Piccone Connie M , Manwani Deepa , Strunk Crawford , Tartaglione Immacolata , Colombatti Raffaella , Akatue Sophia , Oteng Bianca , Owda Ahmed , Bamfo Rose , Wilson Samuel , Rivers Angela , Farooq Fatimah , Urbonya Rebekah , Boatemaa Gifty Dankwah , Rao Sudha , Inusa Baba , Antwi-Boasiako Charles , Segbefia Catherine , Sey Fredericka , Andemariam Biree , Asare Eugenia Vicky , Campbell Andrew D 
Published: February 2022

Abstract

Objectives
Sickle Cell Disease (SCD) is a genetic blood disorder affecting over 1 million people globally. The aim of this analysis is to explore the pain burden of patients with SCD in two countries: the United States and Ghana.

Methods
The Consortium for the Advancement of Sickle Cell Research (CASiRe) was created to better understand the clinical severity of patients with SCD worldwide. Data regarding gender, SCD genotype, prior medical diagnoses, and validated pain burden measures were analyzed from the CASiRe database. The Sickle Cell Pain Burden Interview (SCPBI) was used to assess pain burden, the impact of pain on physical, emotional, and social function.

Results
Most subjects identified as Black/African American (n = 298, 97.0%). Patient ages ranged from 6 to 73 years. 35.9% resided in the United States, 64.1% resided in Ghana, 40.9% were men, and 58.7% were women. The mean SCPBI score for US SCD patients was 6.53(±5.89) vs 4.04(±5.10) for Ghanaian patients, P &lt;0.001. Pain burden was higher in US men vs Ghanaian men (6.74(±5.68) vs 3.54(±4.46), P = .003) and in US women vs Ghanaian women (6.37 ± 6.06 vs 4.44(±5.54), P = .032). Pain burden was higher in US patients than Ghanaian patients for both the Hb SC/SBeta+ genotype (5.40(±5.29) vs 2.82(±4.86), P = .054) and Hb SS/SBeta0 genotype (6.79(±6.01) vs 4.49(±5.13), P = .003). Pain burden was significantly higher in SCD patients with comorbid conditions independent of geographic origin including stroke, cholecystectomy, gallstones, depression, and headache.

Discussion
US patients with SCD have a higher pain burden than Ghanaian patients. Further studies should investigate underlying contributors to pain burden in these populations and further explore the etiology of geographic differences in pain.
Airway misadventures in adult critical care: a concise narrative review of managing lost or compromised artificial airways
Authors: Budde Anna M. , Kadar Rachel B. , Jabaley Craig S. 
Published: February 2022

Purpose of review
Loss or compromise of artificial airways in critically ill adults can lead to serious adverse events, including death. In contrast to primary emergency airway management, the optimal management of such scenarios may not be well defined or appreciated.

Recent findings
Endotracheal tube cuff leaks may compromise both oxygenation and ventilation, and supraglottic cuff position must first be recognized and distinguished from other reasons for gas leakage during positive pressure ventilation. Although definitive management involves tube exchange, if direct visualization is possible temporizing measures can often be considered. Unplanned extubation confers variable and context-specific risks depending on patient anatomy and physiological status. Because risk factors for unplanned extubation are well established, bundled interventions can be employed for mitigation. Tracheostomy tube dislodgement accounts for a substantial proportion of death and disability related to airway management in critical care settings. Consensus guidelines and algorithmic management of such scenarios are key elements of risk mitigation.

Summary
Management of lost or otherwise compromised artificial airways is a key skill set for adult critical care clinicians alongside primary emergency airway management.
When is it safe to resume anticoagulation in traumatic brain injury?
Authors: Ng Ireana C. , Barnes Christopher , Biswas Subarna , Wright David , Dagal Arman 
Published: February 2022

Purpose of review
When to resume or initiate anticoagulation therapy following traumatic brain injury (TBI) is controversial. This summary describes the latest evidence to guide best practice.

Recent findings
Following trauma, prophylactic, and therapeutic anticoagulation (TAC) have been widely encouraged to prevent major comorbidities such as pulmonary embolism and deep venous thrombosis. Increased rebleeding risk and potentially catastrophic outcome from initiation of anticoagulation treatment in TBI are mainly influenced by institutional guidelines or physician preference in the absence of level I or II recommendations. In recent years, there has been an increasing number of TBI in the elderly population on anticoagulation for other medical conditions; this complicates the decision and timing to restart anticoagulation after the injury.

Summary
Strategies and timing to start prophylactic and TAC differ significantly between institutions and physicians. Each TBI patient should be evaluated on a case-by-case basis on when to start anticoagulation. More investigation is required to guide best practice.
Negative Mood Regulation Expectancies (NMRE) as a Moderator of the Association Between Stress and Treatment Outcomes in Interdisciplinary Chronic Pain Treatment
Authors: Blaettler Larissa T. , Goméz Penedo Juan M. , Schwegler Kyrill , Egloff Niklaus , grosse Holtforth Martin 
Published: February 2022

Objective:
Negative mood regulation expectancies (NMRE) describe the expectancies of an individual regarding his or her ability to regulate or reduce negative mood states by certain cognitive or behavioral strategies. NMRE are closely associated with the actual emotion regulation and potentially buffer the negative psychological and physical health consequences of stress. In the context of chronic pain, stress plays a central role, as long-term stress can have additional negative consequences regarding pain and its progression. The present study investigated the relationship of NMRE with treatment outcome, and more importantly, its buffering role in the association between stress and treatment outcomes.

Method:
Two hundred six chronic pain inpatients (fulfilling the International Classification of Diseases, 10th Revision [ICD-10] diagnosis of F45.41) of an interdisciplinary treatment completed standardized self-report questionnaires at intake and discharge. Hierarchical linear regression analyses were used to test the main effects of the Negative Mood Regulation Scale—Short Form on pain intensity, pain-related disability, and psychological distress as treatment outcomes and its moderating role in the association of stress and the 3 outcome measures.

Results:
A significant main effect of NMRE on treatment outcome was only found for psychological distress. However, for all 3 outcome measures, a significant moderating effect of NMRE on the association between stress level and treatment outcome was found.

Discussion:
NMRE appear to play an important role for the outcome of inpatient treatment for chronic pain. Due to their buffering effect on the negative association between stress and therapy outcome, they should be targeted in the treatment of chronic pain.
The Role of Spinal Cord Stimulation in Reducing Opioid Use in the Setting of Chronic Neuropathic Pain
Authors: Smith Cynthia A. , Roman Jessica , Mammis Antonios 
Published: February 2022

Objective:
The aim was to examine research on the impact of spinal cord stimulation (SCS) on the reduction of preimplantation opioid dose and what preimplantation opioid dose is associated with a reduction or discontinuation of opioid use postimplantation.

Methods:
Systematic review of literature from PubMed, Web of Science, and Ovid Medline search of “opioid” and “pain” and “spinal cord stimulator.” Inclusion criteria included original research providing data on SCS preimplantation opioid dosing and 12 months postimplantation opioid dosing or that correlated specific preimplantation opioid dose or opioid dose cutoff with significantly increased likelihood of opioid use discontinuation at 12 months postimplantation.

Results:
Systematic review of the literature yielded 17 studies providing data on pre-SCS and post-SCS implantation dose and 4 providing data on the preimplantation opioid dose that significantly increased likelihood of opioid use discontinuation at 12 months postimplantation. Data from included studies indicated that SCS is an effective tool in reducing opioid dose from preimplantation levels at 12 months postimplantation. Data preliminarily supports the assertion that initiation of SCS at a preimplantation opioid dose of ≤20 to ≤42.5 morphine milligram equivalents increases the likelihood of postimplantation elimination of opioid use.

Discussion:
SCS is an effective treatment for many types of chronic pain and can reduce or eliminate chronic opioid use. Preimplantation opioid dose may impact discontinuation of opioid use postimplantation and the effectiveness of SCS in the relief of chronic pain. More research is needed to support and strengthen clinical recommendations for initiation of SCS use at lower daily opioid dose.
Spinal screening, malignancy, medical therapy, and surgical correction of deformity in pediatric patients with neurofibromatosis type 1: a systematic review
Authors: Suresh Krishna V. , Xu Amy L. , Groves Mari L. , Sponseller Paul D. 
Published: February 2022

The objective of this systematic review was to synthesize evidence regarding spinal screening recommendations, types of spinal and thoracic neurofibromatosis type 1 (NF1) tumors, medical therapy for NF1-associated neoplasms, and treatment with magnetically controlled growing rods (MCGRs) or cervical kyphosis correction in pediatric patients with NF1.
We queried PubMed, Embase, Cochrane Library, Web of Science, Scopus, Clinicaltrials.gov, and medRxiv for studies reporting spinal screening recommendations, prognosis, and medical therapy for NF1-associated spinal tumors and MCGR use or cervical kyphosis correction in pediatric NF1 patients, yielding 758 publications, 33 of which were included.
There is no consensus on spinal screening interval. Computed tomography is recommended for postoperative monitoring. Patients with gangliomas and spinal neurofibromas had nearly complete symptom resolution after resection. Plexiform neurofibromas were most commonly treated with resection and laminectomy; some patients reported tumor enlargement after intervention. Malignant nerve sheath tumors have high rates of metastasis even after chemoradiation and resection. MEK-inhibitors produced limited regression in tumor size. Sirolimus and thalidomide reduced tumor size but caused more severe adverse effects than MEK-inhibitors. Improvements in major curves and T1–T12 height gain were reported after MCGR intervention. Anteroposterior arthrodesis produced the greatest correction of dystrophic cervical kyphosis.
There may be value in establishing standardized spinal screening protocols for pediatric NF1 patients. Surgical correction of NF1-associated spinal deformity is effective, though current medical therapies for spinal tumors have limited success. Areas for further investigation include determining appropriate screening intervals, choice of medical therapy for spinal tumors, and long-term outcomes of MCGRs. Level of Evidence: IV.
Incidence and Risk Factors for Heterotopic Ossification in a Matched Cohort Adolescent Population Undergoing Hip Arthroscopy
Authors: Feroe Aliya G. , Hassan Mahad M. , Flaugh Rachel A. , Maier Stephen P. , Cook Danielle L. , Yen Yi-Meng , Kocher Mininder S. 
Published: February 2022

Background:
Heterotopic ossification (HO) is a known complication after hip arthroscopy in adults, positively associated with larger cam resection, male sex, older age, and obesity, and negatively associated with nonsteroidal anti-inflammatory drug (NSAID) use and capsular closure. However, it has not been well-documented in adolescents. The purpose of this study was to determine the incidence and risk factors for the development of HO in adolescent patients undergoing hip arthroscopy.

Methods:
Clinical and operative records from a pediatric institution were queried to identify patients aged 21 years or younger who underwent hip arthroscopy between 2008 and 2018. The 27 cases that developed HO were matched 1:4 on age and sex with 107 controls. The bivariate analysis assessed the relationship between demographic and perioperative factors on the development of HO. Multivariable logistic regression evaluated the association between prophylactic NSAID use (indomethacin 75 mg, 3 wk) and HO, controlling for surgeon and extent of cam resection (change in alpha angle).

Results:
Twenty-seven of 595 (4.5%) hips that underwent hip arthroscopy developed HO within 2 years of surgery. Prophylactic indomethacin was not significantly associated with developing HO [30% (8/27), P=0.83], after controlling for surgeon and extent of cam resection—nor were age, sex, and body mass index percentile. Of patients who developed HO, a smaller proportion underwent reoperation for HO excision among those who received prophylactic indomethacin than those who did not [13% (1/8) vs. 63% (12/19), P=0.03].

Conclusions:
The incidence of HO within 2 years of hip arthroscopy in this adolescent population was 4.5%. Although studies in the adult hip arthroscopy population have pointed to a protective role of NSAIDs (eg, indomethacin) in radiographic HO, the effect was less certain in this adolescent sample. Larger studies are important to further evaluate the role of prophylactic NSAIDs and variations in arthroscopic technique in developing HO.

Level of Evidence:
Level III—therapeutic, case-control study.
Genu Valgum After Distal Femur Extension Osteotomy in Children With Cerebral Palsy
Authors: Liou Yen-Lyin , Lee Wei-Chun , Kao Hsuan-Kai , Yang Wen-E , Chang Chia-Hsieh 
Published: February 2022

Background:
Distal femur extension osteotomy (DFEO) is a common treatment for knee flexion contracture and crouch gait in patients with cerebral palsy (CP), but skeletally immature patients tend to develop genu valgum deformities after DFEO. This study aimed to report the tendency of valgus changes after DFEO and determine the risk factors for subsequent surgery for excessive genu valgum.

Methods:
This retrospective case-control study included 25 children with CP who underwent DFEO in 44 limbs for knee flexion contractures ≥15 degrees at a mean age of 11.0 years. Radiologic measurements included the anatomic lateral distal femoral angle (aLDFA), anatomic tibiofemoral angle (aTFA), medial proximal tibia angle, and plate-condyle angle, postoperatively and at the latest follow-up. Age, sex, preoperative knee flexion contracture angle, Gross Motor Function Classification System level, and radiographic measurements were compared between children with and without subsequent guided growth for genu valgum.

Results:
A significant valgus change was observed at the distal femur in the first postoperative year (aLDFA from 83.6 to 80.1 degrees, P<0.001; aTFA from 176.1 to 172.5 degrees, P<0.01; plate-condylar angle from 5.3 to 9.5 degrees, P<0.001). Valgus changes occurred in 36 of the 44 limbs (82%) by an average of −4.6 degrees in the aLDFA, and subsequent guided growth was performed in 5 patients (20%). Guided growth for genu valgum was associated with a greater postoperative valgus angle (aLDFA: 78.0 vs. 84.9 degrees, P<0.01) but not with age, Gross Motor Function Classification System level, or preoperative flexion contracture.

Conclusions:
Distal metaphyseal osteotomies and distally placed angled plates near the physis are associated with valgus changes following growth. We recommend making a slight varus alignment during DFEO to compensate for subsequent valgus changes.

Level of Evidence:
Level III—therapeutic, retrospective comparative study.