bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development, Diversity and Dynamics of Plant Architecture in Utricularia subgenus Polypompholyx – Towards Understanding Evolutionary Processes in the Lentibulariaceae
Authors: Reut Markus S. , Płachno Bartosz J. 
Published: August 2022

AbstractTo uncover the nature of various kinds of stolons of Utricularia subgenus Polypompholyx (Lentibulariaceae) we studied branching of stolons by scanning electron microscopy, statistically investigated correlations of stolon types and other traits across 56 species, and evaluated seedling development and process morphological aspects. Some results were compared to the sister genera Pinguicula and Genlisea. A key to nine stolon types in Polypompholyx is provided. Predominant stolon types were rhizoids, runner stolons with rhizoids on nodes, and runner stolons without rhizoids on nodes but with bladders on internodes. Stolon types were taxonomically relevant and correlated to the distribution/climate. They obviously diverged with speciation events in Australia. Examined seedlings of Genlisea and Polypompholyx showed similar developmental patterns. Stolons were homologous to traps and leaves. Selected subterranean organs contained specific but similar process combinations of roots, shoots and/or leaves. We assume the Genlisea-Utricularia ancestor trap included processes of a Pinguicula root and leaf.
Alzheimer’s Disease Prediction Using Attention Mechanism with Dual-Phase 18F-Florbetaben Images
Authors: Kang Hyeon , Kang Do-Young 
Published: August 2022

Abstract
Introduction
Amyloid-beta (Aβ) imaging test plays an important role in the early diagnosis and research of biomarkers of Alzheimer’s disease (AD) but a single test may produce Aβ-negative AD or Aβ-positive cognitively normal (CN). In this study, we aimed to distinguish AD from CN with dual-phase 18F-Florbetaben (FBB) via a deep learning–based attention method and evaluate the AD positivity scores compared to late-phase FBB which is currently adopted for AD diagnosis.

Materials and Methods
A total of 264 patients (74 CN and 190 AD), who underwent FBB imaging test and neuropsychological tests, were retrospectively analyzed. Early- and delay-phase FBB images were spatially normalized with an in-house FBB template. The regional standard uptake value ratios were calculated with the cerebellar region as a reference region and used as independent variables that predict the diagnostic label assigned to the raw image.

Results
AD positivity scores estimated from dual-phase FBB showed better accuracy (ACC) and area under the receiver operating characteristic curve (AUROC) for AD detection (ACC: 0.858, AUROC: 0.831) than those from delay phase FBB imaging (ACC: 0.821, AUROC: 0.794). AD positivity score estimated by dual-phase FBB (R: −0.5412) shows a higher correlation with psychological test compared to only dFBB (R: −0.2975). In the relevance analysis, we observed that LSTM uses different time and regions of early-phase FBB for each disease group for AD detection.

Conclusions
These results show that the aggregated model with dual-phase FBB with long short-term memory and attention mechanism can be used to provide a more accurate AD positivity score, which shows a closer association with AD, than the prediction with only a single phase FBB.
The INTESTINE study: INtended TEmporary STomas In crohN’s diseasE. Protocol for an international multicentre study
Authors: Celentano Valerio , Perrott Claire , Tejedor Patricia , Calini Giacomo , Rottoli Matteo , Kontovounisios Christos , Tekkis Paris 
Published: August 2022

AbstractSurgery for ileocolonic Crohn’s disease can result in temporary or permanent stoma formation which can be associated with morbidity as parastomal and incisional hernias, readmissions due to obstruction or high stoma output, and have a negative impact on quality of life. We propose an international retrospective trainee-led study of the outcomes of temporary stomas in patients with Crohn’s disease. We aim to evaluate both the short-term (6 month) and mid-term (18 month) outcomes of temporary stomas in patients with Crohn’s Disease. Retrospective, multicentre, observational study including all patients who underwent elective or emergency surgery for ileal, colonic and ileocolonic Crohn’s disease during a 4-year study period. Primary outcome is the proportion of patients who still have an ileostomy or colostomy 18 months after the initial surgery. Secondary outcomes: complications related to stoma formation and stoma reversal surgery; time interval between stoma formation and stoma reversal; risk factors for stoma formation and non-reversal of the stoma. We present the study protocol for a trainee-led, multicentre, observational study. Previous research has demonstrated significant heterogeneity surrounding the formation and the timing of reversal surgery in patients having a temporary ileostomy following colorectal cancer surgery, highlighting the need to address these same questions in Crohn’s disease, which is the aim of our research.
<em>‘Things we are expected to just do and deal with’</em>: Using the medical humanities to encourage reflection on vulnerability and nurture clinical skills, collegiality, compassion, and self-care
Authors: Kelly Michaela , Lynch Johanna , Mainstone Penny , Green Alison , Sturman Nancy 
Published: August 2022

The Vulnerability in Medicine (ViM) program was developed to provide protected time and psychologically safe spaces for third-year medical students to consider challenges in the doctor-patient relationship and the clinical workplace. A suite of discussion-prompts presented in a small-group learning environment provides a springboard for students to reflect on their development as clinicians, understand the personhood of their patients, explore the therapeutic relationship, and consider emotional responses and personal, cultural, and social assumptions that impact on care. The program supports students to recognise vulnerability in themselves, the patient, their tutors, and the wider clinical team, as they face the challenge of aligning the clinician they want to become with ideals of professionalism and the imperfect clinical workplace. This 6‑week program focuses on the vulnerability of patients, students, and doctors in a weekly tutorial interposed with clinical placements primarily in geriatric, rehabilitation, or palliative medicine. The tutorials draw from the medical humanities and use experiential, reflective, and narrative learning techniques. They are facilitated by generalist clinicians who model their own vulnerability, humanity, and reflective practice by sharing tutorial tasks equally with students. Students report feeling supported, and appreciate the opportunity to discuss ethical, psychosocial, and emotional aspects of medicine whilst reflecting on what medical practice means to them. Tutors experience a deeper appreciation of student journeys and their own vocations as clinicians and teachers. The sharing of vulnerability exposes the humanity of patients, students, and clinicians, and sustains our whole-person approach to the care of patients, students, and ourselves.
The effect of extended hemodialysis on nutritional parameters: a systematic review
Authors: Majlessi Alireza , Burton James O. , March Daniel S. 
Published: August 2022

Abstract
Objective
This systematic review provides an up-to-date synthesis on the effects of extended hemodialysis on nutritional outcomes.

Design and Methods
Ten databases were searched. Inclusion criteria were: randomised and non-randomised studies of extended hemodialysis (defined by > 15 h/week) with a comparator group which received conventional in-centre hemodialysis (usually ≤ 12 h per week). Outcomes of interest included lean body mass, protein and carbohydrate intake, body mass index, dry lean mass, water-soluble vitamin levels, serum levels of appetite hormones, and nutritional status as assessed by the PEW and SGA scoring tools.

Results
Five studies were eligible. All investigated extended nocturnal hemodialysis (one with the addition of short daily), three were in-centre and two were at home. Range of duration for the included studies was 2–18 months. These studies reported data on lean body mass, protein and carbohydrate intake, body mass index, dry lean mass and water-soluble vitamin levels. There was insufficient homogeneity between the studies to meta-analyse the data. Extended hemodialysis had no significant effects on any of the reported outcomes except for lean body mass, where a significant increase was found, and water-soluble vitamin levels, where deficiency was identified in one of the included studies.

Conclusion
There is currently no evidence to suggest that extended hemodialysis modalities impact nutritional parameters, although the quality of the available evidence is low.

Graphical abstract
Relationship between ozone and biologically relevant UV at 4 NDACC sites
Authors: McKenzie Richard , Liley Ben , Kotkamp Michael , Geddes Alexander , Querel Richard , Stierle Scott , Lantz Kathleen , Rhodes Steve , Madronich Sasha 
Published: August 2022

AbstractClouds and aerosols, as well as overhead ozone, can have large effects on ultraviolet (UV) irradiances. We use statistical methods to remove cloud effects and mean aerosol effects from spectral UV irradiance measurements to investigate the relationship between UV and total column ozone. We show that for fixed solar zenith angles (SZA), seasonal changes in ozone lead to marked changes in clear-sky UV irradiances. Such effects are larger at mid-latitudes than in the tropics. At mid-latitudes, the minimum ozone amount over the course of a year can be about 50 percent of its maximum, with the lowest values in autumn and the highest values in spring. These seasonal ozone changes lead to UV Index (UVI) values in autumn that can exceed those in spring at the same SZA by nearly a factor of two. Differences are even larger for UV spectra weighted by the action spectra for DNA-damaging UV, and for cutaneous previtamin D production. In some cases, the seasonal increase exceeds a factor of 4. The analysis experimentally demonstrates the limits of applicability of the concept of constant Radiative Amplification Factors (RAFs) for estimating effects of changes in ozone for some weighting functions. Changes in DNA-weighted UV and erythemally weighted UV are well represented by the published RAFs. However, there are large SZA dependencies in the case of UVB and vitamin D-weighted UV. For all weightings considered, RAFs calculated from the observations as a function of SZA show similar dependencies between sites, in good agreement with published values, independently of the ozone data source.
Graphical abstract
In the Middle: American Multinationals in China and Trade War Politics
Authors: Liu Rigao , Zhang Jiakun Jack , Vortherms Samantha A. 
Published: August 2022

AbstractWhich factors make some American multinational corporations (MNCs) take political action in response to the US–China Trade War and cause others to stay on the sidelines? We identify China-based subsidiaries of US firms to identify firms’ political actions in response to the trade war. We combine data on firms’ tariff exposure, economic actions in China, and political actions in the United States during the trade war. Together these data highlight the divergent strategies with which firms engage. Even though more than 63 percent of MNCs in our sample were adversely impacted by tariffs, only 22 percent voice opposition and 7 percent exit in response to the trade war. Our analysis reveals that US MNCs in China differ in their business models, ownership structure, experience in China, and size of capital investments. These firm-level factors determine the degree to which US MNCs are embedded in China. This in turn shapes how firms perceive political risk and choose from the menu of options to deal with the trade war. Size and age increase voice while joint-venture status decreases it.
Evidence for Pleistocene periglaciation in the lowlands of central Argentina (36–39°S)
Authors: Vogt Théa 
Published: August 2022

AbstractPleistocene permafrost has been recognized in the lowlands of extra-Andean Argentina from Tierra del Fuego to the Rio Negro valley at 40°S, and to the Sierras Australes at 38°S. Features that could have formed only by cryogenic activity at elevations between 230–400 m above sea level in surficial deposits and in the bedrock beneath are described here as far north as 36°S. These features are not as pronounced as they are farther south because most of central Argentina was a cold desert during the glacial episodes, and therefore little ice formed. Calcareous dust, formerly considered as pedogenic and now known to be glaciogenic, is closely associated with these features. Secondary precipitates, such as lamellar crystals of calcite and gypsum, and other microscopic features like those observed in perpetually frozen ground also confirm that this region experienced permafrost at some time. These new findings mean that the area affected by periglaciation is much larger than previously thought and expanded more than 200 km farther to the north. Stratigraphic evidence and geomorphological features place both deposits and cryogenic features within them as early–middle Pleistocene age.
A multimethod approach to the genesis of Menga, a World Heritage megalith
Authors: García Sanjuán Leonardo , Medialdea Alicia , Balsera Nieto Verónica , Athanassas Constantin , Pike Alistair , Standish Christopher D. , Dias Maria Isabel , Rodrigues Ana Luisa , Clavero Toledo José Luis , Wheatley David W. , Cintas-Peña Marta 
Published: August 2022

AbstractThe scientific study of Neolithic monuments holds fundamental keys to the analysis of early social complexity. This is often impeded by the challenges involved in understanding their temporality and, particularly, their initial construction dates. This problem is most severe in monuments that were not predominantly used for burial and went on to have long biographies in which activity in later periods obliterated the material record of the earliest phases. That was certainly the case of the Menga dolmen, part of the Antequera World Heritage site (Málaga, Spain), and one of the most remarkable megaliths in Europe, for which, after nearly 200 years of explorations and research, no firm chronology existed. The research presented in this paper shows how this problem was tackled through a multimethod, scientific, and geoarchaeological approach. The analysis of 29 fresh numerical ages, including radiocarbon determinations as well as optically stimulated luminescence, thermoluminescence, and uranium-thorium dates, led to the successful establishment of Menga's construction date and the subsequent contextualization of the monument within the social and cultural background it arose in. Placing the dolmen in the context of its time of “birth” introduces entirely new possibilities for its interpretation, both in terms of local and supralocal social and cultural processes.
Les termes transplantés : une approche réflexive de la philosophie en chinois moderne
Authors: Zhou Xiyin 
Published: August 2022

RésuméAprès la dispute soutenue à partir des années 1990 sur la question de savoir s'il y a une philosophie chinoise, plusieurs intellectuels chinois, y compris et surtout des philosophes, ont commencé, depuis une dizaine d'années, à se réunir autour d'une problématique plus concrète : « une philosophie en langue chinoise est-elle possible ? » ou « comment raisonner en chinois moderne ? » Parmi de nombreux sujets, celui des « termes transplantés » initié par Chen Jiaying (1952-) a attiré l'attention générale. Cet article compte, en s'appuyant sur son travail, introduire et approfondir ce problème en tant que défi particulier pour la pratique philosophique en chinois.
The Peaceful Origins of North Korea's Nuclear Programme in the Cold War Period, 1945–1965
Authors: Woo Donghyun 
Published: August 2022

AbstractWas Kim Il-sung's desire to have nuclear weapons the sole reason for North Korea's quest for nuclear power? The answer, I argue, is highly unlikely given that extensive economic considerations played the most fundamental role in North Korea's pursuit of atomic energy from 1945 to 1965. With original, creative research on previously unexamined North Korean publications and Soviet archival materials, I demonstrate how the ‘peaceful’ impetus steered North Korea's early nuclear enterprises in the Cold War period. While previous studies draw only upon circumstantial evidence to argue that North Korea's going nuclear was predestined due to its security concerns, this article revises this teleological assumption by reconstructing historical contexts wherein the two driving factors that formed early North Korea's nuclear programme were mostly emulating how the Soviets harnessed nuclear power for economic gain, and aversion to the Americans’ use of nuclear power for atomic weapons to a lesser degree. That is, North Korea, like other countries in what later would be termed the Global South, sought to master nuclear technology for industrial ends in the first place, which turned out to be economically burdensome to continue, long before September 1965 when its first research reactor went online.
How Do Board Reforms Affect Debt Financing Costs Around the World?
Authors: (Zhao) Chiu Hui , Lin Chen , Wei Lai 
Published: August 2022

AbstractIn this study, we examine the effect of worldwide board reforms on the cost of debt financing. We document an increase of loan spread after a country initiates the reform. The increase is larger among firms that are more exposed to shareholder–debtholder conflicts. The results suggest that board reforms empower shareholders at the cost of debtholders. However, we also find that, while the reform component related to board independence leads to the increase in the cost of debt, the component related to audit committee independence helps decrease the cost.
Global epidemiology and molecular biology of Taenia multiceps: a comparative meta-analysis and in silico analysis study
Authors: Abbas Ibrahim , El-Alfy El-Sayed , Saleh Somaya , Tamponi Claudia , Varcasia Antonio 
Published: August 2022

AbstractIn the present study, all published data on the epidemiology and molecular characters of Taenia multiceps were systematically collected from relevant databases (e.g. PubMed, Scopus, National Center for Biotechnology Information), and combined in various statistical and genetic analyses as a contribution to a better understanding of the epidemiology of this ubiquitous taeniid worldwide. While 5.8% of the key hosts (dogs) from various countries had T. multiceps, grey wolves displayed the highest prevalence (21.6%) among the definitive hosts. Small ruminants are the main intermediate hosts and carry the coenuri in various locations, but most commonly in the central nervous system (CNS). Cerebral coenuri were confirmed in 53% of sheep exhibiting neurological symptoms, and infected animals often had only a single coenurus in the brain. Sheep had a higher prevalence (8.8%) of CNS coenuri than goats (5.8%); however, extra-CNS coenuri were detected more frequently in goats than in sheep. In either case, the difference between sheep and goats was statistically insignificant. Analysis of 233 partial cytochrome oxidase subunit I nucleotide sections for T. multiceps revealed high haplotype and low nucleotide diversities. Fifty-one haplotypes were detected circulating in 6 geographic populations. China, Iran and Turkey had 2 major haplotypes, whereas Italy and Egypt shared 3. Haplotypes from Greece circulate worldwide, and displayed similar gene flow values when compared with the other populations. There were no distinct patterns for haplotype distribution in relation to the infected hosts or coenuri locations. The existence of genetic variants in T. multiceps was highlighted, but needs further studies.
Resolving heterogeneity in depression using individualized structural covariance network analysis
Authors: Han Shaoqiang , Zheng Ruiping , Li Shuying , Zhou Bingqian , Jiang Yu , Fang Keke , Wei Yarui , Pang Jianyue , Li Hengfen , Zhang Yong , Chen Yuan , Cheng Jingliang 
Published: August 2022

AbstractBackgroundElucidating individual aberrance is a critical first step toward precision medicine for heterogeneous disorders such as depression. The neuropathology of depression is related to abnormal inter-regional structural covariance indicating a brain maturational disruption. However, most studies focus on group-level structural covariance aberrance and ignore the interindividual heterogeneity. For that reason, we aimed to identify individualized structural covariance aberrance with the help of individualized differential structural covariance network (IDSCN) analysis.MethodsT1-weighted anatomical images of 195 first-episode untreated patients with depression and matched healthy controls (n = 78) were acquired. We obtained IDSCN for each patient and identified subtypes of depression based on shared differential edges.ResultsAs a result, patients with depression demonstrated tremendous heterogeneity in the distribution of differential structural covariance edges. Despite this heterogeneity, altered edges within subcortical-cerebellum network were often shared by most of the patients. Two robust neuroanatomical subtypes were identified. Specifically, patients in subtype 1 often shared decreased motor network-related edges. Patients in subtype 2 often shared decreased subcortical-cerebellum network-related edges. Functional annotation further revealed that differential edges in subtype 2 were mainly implicated in reward/motivation-related functional terms.ConclusionsIn conclusion, we investigated individualized differential structural covariance and identified that decreased edges within subcortical-cerebellum network are often shared by patients with depression. The identified two subtypes provide new insights into taxonomy and facilitate potential clues to precision diagnosis and treatment of depression.
China's Water Governmentality and the Shaping of Hydrosocial Territories in the Lancang-Mekong Region
Authors: Wang Raymond Yu , Liu Xiaofeng , Zhang Wenya 
Published: August 2022

AbstractThis paper examines China's water governmentality in advancing the Lancang-Mekong Cooperation (LMC). It attends to how discourses, used as a political instrument, are framed, justified and contested in the reshaping of international hydrosocial territories. China's official and popular discourses present the LMC as promoting multilateral politics, economic benefits and social integration, while they obscure polarizing politics, external interventions and regional conflicts. Using strategies of positive publicity first, top-down communication and mutual empathy creation, these discourses aim to deflect attention away from controversies and geopolitics in the region to construct governable hydrosocial territories. However, in a transnational context where the Chinese state cannot unilaterally control geographical imaginaries, alternative discourses depict China as a “hydro-hegemon” that poses threats to downstream countries. The discursive dichotomy reflects multiple ontologies of water and power struggles in international river governance, bringing regional stability and sustainable development into question.