bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence trend and prognosis of intrahepatic cholangiocarcinoma: a study based on the SEER database
Authors: Yang Juqin , Wang Xiaoguang , Zhou Zhongcheng , Chen Xujian , Wu Bin 
Published: April 2022

Abstract
Background: Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) have different cellular origins; therefore, ICC is significantly different from HCC in terms of aetiology, mechanism, tumour biological behaviour, treatment methods, and prognosis. The objective of this study was to investigate the current incidence trend and prognosis of intrahepatic cholangiocarcinoma (ICC) and deepen the understanding of ICC. Methods A large sample of ICC and hepatocellular carcinoma (HCC) patient data was obtained from the Surveillance, Epidemiology and End Results (SEER) database of the National Cancer Institute (NCI), USA. The incidence trend, prognosis, and the effect of surgery and lymph node dissection on the prognosis of ICC patients were analysed. Results In recent years, the incidence of ICC has increased. The prognosis of ICC patients is significantly worse than that of HCC patients. Surgery can benefit all stages of ICC, and lymph node dissection is beneficial for the prognosis of patients with positive lymph nodes (N1). Conclusion In recent years, the incidence of ICC has been increasing, and its prognosis remains poor, which is a cause for concern.
Effect of internet-based UP-A intervention on stress, anxiety, depression, and psychological flexibility during the COVID-19 pandemic: A clinical trial
Authors: Javadi Vahideh , Ahmadi Farzane , Ebrahimi Leila Salek , Mousavi Seyedeh Elnaz 
Published: April 2022

Abstract

Objective: The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A) has been shown to be effective for reducing symptoms of anxiety and depression in adolescents with emotional disorders. The present study aims to assess the effectiveness of internet-based UP-A in reducing stress, anxiety, and depression, and psychological flexibility of adolescents with subclinical features of emotional disorder during the COVID-19 pandemic.Methods: This is a longitudinal randomized clinical trial conducted on 40 adolescents aged 12-17 years with subclinical features of emotional disorder. They were assigned randomly into two groups of intervention (n=20) and control (n=20). They first completed the Depression Anxiety Stress Scale- 21 item (DASS-21) and the Acceptance and Action Questionnaire (AAQ-2) online. Then, the intervention group received 12 sessions of UP-A through video call on WhatsApp, two days per week each for 45 minutes. The control group received no treatment. Immediately and 3 months after the intervention, the questionnaires were completed again. Collected data were analyzed using longitudinal marginal modeling.Results: The stress, anxiety, and depression levels of adolescents decreased and their psychological flexibility increased immediately and 3 months after the intervention. The marginal modeling showed the interaction effect of time and group (p<0.05), indicating that the difference between groups was significant at all three time points. Conclusion: Online transdiagnostic therapy based on the UP-A is effective in reducing the symptoms of anxiety, depression, stress, and improving psychological flexibility of adolescents during the COVID-19 pandemic.
High-throughput interspecies profiling of acidic plant hormones using miniaturised sample processing
Authors: Široká Jitka , Brunoni Federica , Pěnčík Aleš , Mik Václav , Žukauskaitė Asta , Strnad Miroslav , Novák Ondřej , Floková Kristýna 
Published: April 2022

Abstract
Background: Acidic phytohormones are small molecules controlling many physiological functions in plants. A comprehensive picture of their profiles including the active forms, precursors and metabolites provides an important insight into ongoing physiological processes and is essential for many biological studies performed on plants.Results: A high-throughput sample preparation method for liquid chromatography–tandem mass spectrometry determination of 25 acidic phytohormones classed as auxins, jasmonates, abscisates and salicylic acid was optimised. The method uses a small amount of plant tissue (less than 10 mg fresh weight) and acidic extraction in 1 mol/L formic acid in 10% aqueous methanol followed by miniaturised purification on reverse phase sorbent accommodated in pipette tips organised in a 3D printed 96-place interface, capable of processing 192 samples in one run. The method was evaluated in terms of process efficiency, recovery and matrix effects as well as establishing validation parameters such as accuracy and precision. The applicability of the method in relation to the amounts of sample collected from distantly related plant species was evaluated and the results for phytohormone profiles are discussed in the context of literature reports.Conclusion: The method developed enables high-throughput profiling of acidic phytohormones with minute amounts of plant material, and it is suitable for large scale interspecies studies.
Multi-step-ahead soil temperature forecasting at multiple-depth based on meteorological data: Integrating resampling algorithms and machine learning models
Authors: Khosravi Khabat , Golkarian Ali , Barzegar Rahim 
Published: April 2022

Abstract
Direct soil temperature (ST) measurement is time-consuming and costly; thus, the use of a simple and cost-effective machine learning (ML) tool is helpful. In this study, ML approaches, including KStar, instance-based K-nearest learner (IBK) and locally weighted learner (LWL) coupled with resampling algorithms of bagging (BA) and dagging (DA) were developed and tested for multi-step ahead (3, 6 and 9 days ahead) ST forecasting. In addition, a linear regression model (LR) was used as a benchmark to compare the results. A dataset with daily ST time-series (as models’ output) along with meteorological data (mean (TMean), minimum (TMin) and maximum (TMax) air temperature, evaporation (Eva), sunshine hours (SSH) and solar radiation (SR); as models’ input) were collected at Isfahan synoptic station (Iran), in a farmland, during 13 years (1992–2005) at 5 and 50 cm soil depths. Six different input combination scenarios were proposed to the models based on Pearson’s correlation coefficients between inputs and outputs. For the model building, we used 70% of the data and the remaining 30% was considered for model evaluation through different visual and quantitative metrics. Our findings showed that variable TMean is the most effective input variable for ST forecasting in most of the developed algorithms, while in some cases the combination of several variables including TMean, TMax and as well as the integration of TMean, TMax, TMin, Eva and SSH proved to be the best input combinations. Among the evaluated models, KStar showed more compatibility with the BA algorithm, while, in most cases and depending on soil depth, IBK and LWL obtained more accurate results when they were hybridized with DA. For soil depth of 5 cm, BA-KStar has superior performance (i.e. Nash-Sutcliffe Efficiency (NSE) = 0.90, 0.87 and 0.85 for 3, 6 and 9 months ahead forecasting, respectively) while for soil depth of 50 cm, DA-KStar outperforms other algorithms (i.e. NSE = 0.88, 0.89 and 0.89 for 3, 6 and 9 months ahead forecasting, respectively). Also, results confirmed that all hybrid models had higher prediction capability than the LR model.
Evaluation of lipid peroxidation and total antioxidant capacity in patients with uterine cancer
Authors: shademan behrouz , Mahboob Soltan Ali , Ravanbakhsh Ghodsie , Nourazarian Alireza 
Published: April 2022

Abstract
Oxidative stress has been associated with developing many female reproductive diseases, including uterine cancer. This study investigated lipid peroxidation levels and antioxidant enzyme activity in women with uterine cancer. Blood samples were collected from 50 patients with uterine cancer and 50 healthy subjects as a control group. All subjects gave their informed consent. The blood samples were measured for superoxide dismutase, catalase, glutathione peroxidase, total antioxidants, malondialdehyde, and lipid profiles. Hemoglobin levels of the control group and patients were also measured. Serum levels of TG, LDL, and cholesterol were higher in the patients than in the healthy group but not statistically significant (p > 0.05). Serum HDL levels were lower in the patient group than in the healthy group. However, this decrease was not statistically significant (p > 0.05). The mean levels of glutathione peroxidase (GPx), catalase (CAT), and total antioxidant capacity (TAC) were increased in the patient group compared to the control group, but this increase was not statistically significant (p > 0.05). The mean serum levels of malondialdehyde (MDA) and SOD were increased in the patient group, which was statistically significant (p < 0.05). In addition, the hemoglobin level of patients with uterine cancer was decreased compared to the control group, which was statistically significant (p < 0.05). To develop treatment strategies for disease management. Increased serum levels of MDA and SOD and decreased hemoglobin in the blood of patients with uterine cancer can be considered diagnostic biomarkers. However, further studies are needed to confirm these findings.
The Use of Phosphogypsum for Soil Bricks Manufacturing as an Alternative for Its Sustainable Destination
Authors: FILHO João Alexandre PASCHOALIN , CHAVES Hendrio Carvalho , GHERMANDI Andrea , DIAS António José GUERNER , CARVALHO David , RIBEIRO Joana 
Published: April 2022

Abstract
This research studies soil-compacted bricks using Phosphogypsum (PG) in their dosage. Aiming to assess the physical characteristics of these bricks, laboratory tests were performed. To obtain the bricks, two dosages were used: 4 and 7% of Phosphogypsum (PG) concentration. Bricks with no Phosphogypsum (PG) in their mixture were also assessed as a benchmark. The brick's physical characteristics were obtained for bricks dried by the sun and in an oven at 900oC for 96 hours. The results of the laboratory tests were analyzed through statistical analysis to explore the differences between the means for each studied condition (dosage and drying method). We found no statistically significant difference between the mean strength of bricks with 4% of Phosphogypsum (PG) in their dosage and bricks with no PG. Beyond 4% of Phosphogypsum (PG) dosage, the brick's strength presented a reduction. For all dosages, bricks dried in the oven showed higher strength than bricks dried by the sun. However, according to the Brazilian Technical Standards, all studied bricks presented enough strength to be used in regular constructions. We conclude that Phosphogypsum (PG) for brick manufacturing can be an alternative way for its disposal, which can help mitigate the civil construction environmental impacts.
Correlation of Cardiac Output Estimation by Analysis of Arterial Blood Pressure Waveforms versus Continuous Pulmonary Artery Thermodilution in Post Cardiac Surgery Intensive Care Unit Patients
Authors: Khanna Ashish K. , BA Lillian Nosow , Sands Lauren , Saha Amit , Agashe Harsha , Harris Lynnette , Martin R. Shayn , Marchant Bryan 
Published: April 2022

Abstract
Purpose
We sought to assess agreement of cardiac output estimation between continuous pulmonary artery catheter (PAC) guided thermodilution (CO-CTD) and a novel method that performs an analysis of multiple beats of the arterial blood pressure waveform (CO-MBA) in post-operative cardiac surgery patients.
Methods
PAC obtained CO-CTD measurements were compared with CO-MBA measurements from analysis of arterial blood pressure waveforms using the Argos monitor (Retia Medical; Valhalla, NY, USA), in prospectively enrolled adult cardiac surgical intensive care unit patients. Correlation between paired values of CO-CTD and CO-MBA was computed, and agreement was assessed via Bland-Altman analysis. Subgroup analysis was performed on data segments identified as arrhythmia.
Results
927 hours of monitoring data from 79 patients was analyzed, of which 26 had arrhythmia. Mean CO-CTD was 5.29 ± 1.14 L/min (bias ± precision), whereas mean CO-MBA was 5.36 ± 1.33 L/min, (4.95 ± 0.80 L/min and 5.04 ± 1.07 L/min in the arrhythmia subgroup). Mean of differences was 0.04 ± 1.04 L/min, 95% limits of agreement: -2.00 to 2.08 L/min, and a percentage error of 38.2%. In the arrhythmia subgroup, mean of differences was 0.14 ± 0.90 L/min, 95% limits of agreement: -1.63 to 1.91 L/min and percentage error of 35.4%. Paired observations showed a moderate correlation throughout the cohort (r = 0.64).
Conclusion
CO measurements using a novel multi-beat analysis of the arterial pressure waveform are reasonably correlated with traditional more-invasive continuous PAC thermodilution guided cardiac output measurements in adult patients after cardiac surgery including in those with arrythmias.
Response of seed germination and seedling emergence of Haloxylon ammodendron to climate change in desert ecosystem
Authors: Zhu Yajuan , Jia Zhiqing , Wang Guoje 
Published: April 2022

Abstract
Climate change will result in the variation of rain frequency and warming in arid zone, which is expected to affect seed germination and seedling emergence in desert ecosystem. However, the effect of unpredictable rainfall and increasing temperature on seed germination and seedling emergence of dominant desert plants remains unclear across different deserts, which is important for population regeneration and community succession in desert ecosystem. Seed germination and seedling emergence of Haloxylon ammodendron across four desert in Northwest China was examined at different rain frequencies, and constant and alternating temperatures, to investigate their response to climate change. Rain frequency determined seed germination and seedling emergence of H. ammodendron in Tengger Desert, Badain Jaran Desert, Gurbantonggut Desert and Mutthar Desert, which was maximal at rain frequency of 10 times per month and decreased with a decrease of rain frequency. Temperature was not a restricting factor for seed germination of H. ammodendron in Tengger Desert, Badain Jaran Desert and Gurbantonggut Desert, varying from 10 °C to 25 °C and from 20/10 °C to 30/15 °C, respectively. However, the highest temperature of 25 °C and 30/15 °C inhibited seed germination of H. ammodendron in the Mutthar Desert. Haloxylon ammodendron had an opportunistic germination strategy to adapt to the arid climate. Under climate change in the future, seed germination and seedling emergence of H. ammodendron would be restricted by the combination of less frequent rainfall and increased temperature in desert ecosystem. The regeneration of H. ammodendron community should be promoted by irrigation and seedling transplant.
Targeted degradation of IKZF2 for cancer immunotherapy
Authors: Solomon Jonathan , Bonazzi Simone , d'Hennezel Eva , Beckwith Rohan , Xu Lei , Fazal Aleem , Magracheva Anna , Ramesh Radha , Cernijenko Artiom , Antonakos Brandon , Bhang Hyo-eun , Caro Roxana Garcia , Cobb Jennifer , Ornelas Elizabeth , Ma Xiaolei , Wartchow Charles , Clifton Matt , Forseth Ry , Fortnam Bethany , Lu Hongbo , Csibi Alfredo , Tullai Jennifer , Carbonneau Seth , Thomsen Noel , Larrow Jay , Chie-Leon Barbara , Hainzl Dominik , Gu Yi , Lu Darlene , Meyer Matthew , Alexander Dylan , Kinyamu-Akunda Jacqueline , Sabatos-Peyton Catherine , Dales Natalie , Zecri Frederic , Jain Rishi , Shulok Janine , Wang Y. Karen , Briner Karin , Porter Jeffrey , Tallarico John , Engelman Jeffrey , Dranoff Glenn , Bradner Jay , Visser Michael 
Published: April 2022

Abstract
Growing malignant tumors must evade destruction by the immune system, a hurdle some malignancies overcome by attracting immune-suppressive regulatory T-cells (Tregs)1. The IKZF2 (Helios) transcription factor plays a crucial role in maintaining function and stability of Tregs, and IKZF2 deficiency enhances immune responses to tumors in mice2, suggesting IKZF2 may be an attractive target for cancer immunotherapy. Here we describe the discovery and characterization of DKY709, the first molecular glue degrader of IKZF2/4 which spares IKZF1/3. DKY709 was identified through a recruitment-guided medicinal chemistry campaign that redirected the degradation selectivity of CRBN binders towards IKZF2.
The IKZF transcription factor selectivity of DKY709 was rationalized by the X-ray structure of the CRBN-DKY709-IKZF2(ZF2) ternary complex. Upon exposure to DKY709, human Tregs showed reduced suppressive activity and exhausted T-effector cells recovered IFNγ production. In vivo, oral treatment with DKY709 drove a rapid and sustained degradation of IKZF2 including in humans and led to delayed tumor growth in mice with humanized immune systems and enhanced immunization responses in monkeys. DKY709 is a first-in-class, potent and selective oral IKZF2/4 degrader currently being investigated in a phase 1 clinical trial as an immune-enhancing agent for cancer immunotherapy.
Clinical efficacy and imaging analysis for the surgical treatment of thoracolumbar infections in elderly patients: A retrospective study
Authors: Wan Zongmiao , Zhong Yanlong , Tang Benyu , Lai Qi , Sheng Yonghong , Li Chao , Guo Jia , Luo Shiwei , Yao Haoqun 
Published: April 2022

Abstract
BackgroundFew reports have been conducted to comparing surgical results and safety evaluations between the different types of infections in geriatric patients with thoracolumbar infections. The aim of this study is to investigate the safety and efficacy of surgical treatment for thoracolumbar infections in elderly patients.Methods21 patients with pyogenic spondylodiscitis (PS) and 26 patients with tuberculous spondylodiscitis (TS) were enrolled in the study. All patients were treated using one-stage posterior debridement, decompression, and pedicle screw fixation. Comparison of operative safety parameters between the two groups. Clinical efficacy was evaluated using visual analogue scale (VAS) score, the American Spinal Injury Association (ASIA) grade, the short form (SF)-36 survey and Oswestry disability index (ODI) to determine patient quality of life pre- and post-operatively. Results Hospitalisation and intensive care unit duration in the PS group were significantly shorter than in the TS group (P<0.05). The total incidence of post-operative complications for both groups was 44.7%. More complications occurred in the TS group, but the difference was not significant. The VAS and SF-36 scores (physical component) were significantly better in the PS group six months post-operatively, and the SF-36 (mental component) scores were significantly better in the PS group at the one-year follow-up. Neurological status in both groups improved post-operatively, and 83% of the patients were satisfied with the results of their operation. Imaging results showed that bone graft fusion improved in both groups at six months, one year and at the final follow-up. ConclusionOne-stage posterior debridement, decompression, interbody fusion, and internal fixation can be considered a safe and effective method of treating spinal infections in the elderly. This method can improve nerve function, reconstruct spinal stability, and enhance the quality of life of elderly patients. Both PS and TS who underwent surgery achieve similar clinical and radiological results.
Obtaining a relativistic dispersion formula and practice of its application.
Authors: Chernov Andrey 
Published: April 2022

Abstract
The main prerequisite for creating a new dispersion formula was the external similarity of such physical processes as the refraction of light in a transparent substance and the deflection of light by the gravitational field of massive cosmic bodies. Based on the external similarity, a hypothesis was put forward about the internal similarity of these two physical processes. This made it possible to apply Einstein's relativistic formula to the process of light propagation in electron clouds (fields) of transparent substances. As a result, on the basis of this well-known formula, a dispersion formula with a wide range of action was obtained. The new physical formula was used to calculate 26 refractive indices of light in 5 transparent substances in three states of aggregation. Comparison of the obtained indicators with laboratory indicators showed the high accuracy of the new dispersion formula, which amounted to ±10 -7−10 -5 in the calculated wavelength ranges of more than 100 nm. In addition to obtaining a new exact dispersion formula, the successful application of the relativistic formula to processes occurring inside matter at the atomic level allows us to look at the nature of the interaction of light and matter from a new angle.
New approaches of patients with varicocele for different forms of pathospermia depending on age
Authors: Panchenko R. I. , Garmash O. N. , Gorbunkov V. Ya. , Baichorov E. Kh. 
Published: April 2022

Introduction. Varicocele is a testicular varicose vein caused by pathological venous reflux. It is most common in infertile men. Clinically, varicocele is found in 15% of the male population, while in 35% of men with primary infertility and in 70–81% of men with secondary infertility. Varicocele, not accompanied by pain, is the most common cause of the development of pathospermia and infertility. Varicocele is detected at the age of 10 years in 1% of boys, increasing to puberty up to 15%. At the age of 50–80 years, the incidence of varicocele increases to 75–77.3%, thus adding an average of 10% every 10 years of life.Aim is to investigate the fertility restoration after surgical procedures and the prognostic criteria for its restoration depending on age and the proposed medical rehabilitation.Materials and methods. In the urological hospital for a short stay of the state autonomous healthcare institution of the Stavropol Territory “Regional Clinical Specialized Uro-Andrology Center” from 2011–2019. 1143 varicocelectomies were performed (244 laparoscopic varicocelectomy, 975 microsurgical varicocelectomy). The study is based on a comparative analysis of the results of examination of 100 patients with pathospermia and varicocele in the period from 2011 to 2019, who received surgical treatment and did not have concomitant pathology. All patients were followed up for 18 months after surgery.Results and discussion. The pain syndrome was stopped in 100% of cases in the studied patients. Progression of hypotrophy of the left testicle in the postoperative period was not detected. Relapses and other complications were not noted. Patients in the control group were also observed for 1.5 years with an interval of 6 months. Deterioration of spermatogenesis in this group was not detected.Conclusions. It was revealed that varicocele was the main cause of spermatogenesis and fertility disorders in the studied groups. Surgical treatment is a pathogenetically grounded and statistically proven method of restoring fertility in varicocele. After varicocelectomy, adequate medical rehabilitation allows to normalize the qualitative and quantitative parameters of sperm in most clinical cases as soon as possible (up to 3 months).