bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-clinical efficacy of CD20-targeted chimeric antigen receptor T cells for non-Hodgkin's lymphoma
Authors: Wen Hairuo , Lou Xiaoyan , Qu Zhe , Qin Chao , Jiang Hua , Yang Ying , Kang Liqing , Geng Xingchao , Yu Lei , Huang Ying 
Published: November 2022

Abstract
Background
A 4-1BB/CD3-ζ-costimulated CAR-T against CD20 (CAR-T20) was subjected to a systemic efficacy evaluation in a cell co-culture model, and NOD-SCID IL-2 receptor gamma null mice (short for NSG mice) were xenografted with human Burkitt's lymphoma Raji cells.

Methods
CAR-T20 cells were incubated with target cells (K562, K562 CD20 or Raji cells) at ratios of 10:1 and 5:1 for 24 h, and the killing rate was estimated by an LDH cytotoxicity assay. To evaluate the effect of CAR-T20 on the survival time of tumor-bearing animals, 30 NSG mice were employed, and Raji-Luc cells (5 × 105 cells per mouse) were administered prior to CAR-T20 administration. The survival time, optical intensity of Raji-Luc cells, clinical symptoms, and body mass of the animals were observed. Another 144 male NSG mice were employed to investigate the proliferation and antitumor effects of CAR-T20. Human cytokine and murine cytokines were detected at 1, 7, 14, 21, 28, 42, 56 and 90 days post-CAR-T administration, while biochemistry index analysis, T-cell and CAR-T-cell detection in peripheral blood, and histopathological examination were performed at 14, 28, 56 and 90 days post-administration.

Results
CAR-T20 cells had a specific killing effect on CD20-expressing cells in vitro. At a dose of 1 × 106 per mouse or above, CAR-T20 prolonged the median survival time from 14 days to more than 3 months, inhibited the proliferation of Raji cells in mice, and alleviated the clinical manifestations and weight loss caused by the Raji-Luc cell load. CAR-T20 at a dose of 2 × 106 per mouse or above inhibited the proliferation of Raji cells in mice for up to 111 days post-administration without recurrence. The numbers of T cells and CAR-T cells in the animals administered CAR-T20 increased significantly when Raji cells were markedly proliferated and subsequently decreased when Raji cells were predominantly inhibited. CAR-T20 increased human IFN-γ, murine TNF and murine IL-6 levels and decreased human IL-10 levels in tumor-bearing mice. The incidences of xenografted tumors in organs/tissues were also reduced effectively by CAR-T20.

Conclusion
The effective dose of CAR-T20 in mice starts from 1 × 106 per mouse, equivalent to a clinical dose of 5 × 106/kg. Together, our data support the clinical translation of CAR-T20 for R/R B-cell NHL patients.
Intentions in Ecological Psychology: An Anscombean Proposal
Authors: Segundo-Ortin Miguel , Kalis Annemarie 
Published: November 2022

AbstractAccording to ecological psychology, agency is a crucial feature of living organisms: therefore many ecological psychologists maintain that explaining agency is one of the core aims of the discipline. This paper aims to contribute to this goal by arguing that an ecological understanding of agency requires an account of intention. So far, intentions have not played a dominant role in ecological accounts of agency. The reluctance to integrate a notion of intention seems to be motivated by the widespread assumption that intentions should be understood as internal states with representational content. This assumption goes against two main tenets of ecological psychology: its anti-representationalist stance and its claim that perception is direct (in the sense of not being mediated by inferential processes). Ecological psychology thus needs a different answer to the question what intentions are. In this paper, we aim to show that Elizabeth Anscombe’s theory of intention can be fruitfully brought to bear on an ecological theory of agency. We will argue that Anscombe’s account can meet the two challenges of bringing intentions into the framework of ecological psychology: firstly it can explain what intentions are, if not representational states; and, secondly, it can show how our perception of affordances is guided by intention without undermining the idea of direct perception.
Macroeconomic and distributive effects of increasing taxes in Spain
Authors: Fuster Luisa 
Published: November 2022

AbstractI assess the macroeconomic and redistributive effects of tax reforms aimed at increasing tax revenue in Spain. To this end, I develop a theory of entrepreneurship that mimics key facts on the wealth and income distribution in Spain. I find two reforms that raise fiscal pressure in Spain to the average value among countries in the Euro area. The first reform involves doubling the average effective tax rate on labor and business income for all individuals whose income is above a threshold level. I find that this reform reduces the inequality in after-tax income, wealth, and consumption. However, it implies a substantial GDP reduction. The second reform increases the flat tax rate on consumption by fifteen percentage points. While this reform does not reduce long-run output, it does not decrease household inequality. All in all, the desirability of the two reforms depends on the government’s preferences for reducing inequality at the expense of aggregate output losses.
Long-term follow-up after introduction of a systematic sexually transmitted infection screening program for men having sex with men living with HIV in a primary care setting: uptake, STI incidence, and risk factors for infection and reinfection
Authors: Mathé Philipp J. G. , Usadel Susanne , Rieg Siegbert , Kern Winfried V. , Müller Matthias C. 
Published: November 2022

Abstract
Purpose
Annual screening for asymptomatic infections with Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) is recommended by international guidelines in people living with HIV but uptake in routine care remains poor. This study analyzed the effects of the implementation of a CT/NG screening program in a primary HIV treatment center.

Methods
In this single-center cohort study, we included men having sex with men (MSM) living with HIV during the study period from January 2016 to December 2019. From January 2018 on, annual sexual health counseling including CT/NG screening was proactively offered to all MSM presenting at the center. CT/NG screening rates, test positivity rates and case detection rates in the years 2018 and 2019 were compared to those in the years 2016 and 2017.

Results
A total of 234 patients were enrolled in the study contributing to 798.7 patient years (py) during the four-year study period. Screening rates increased from 3.1% and 3.9% in 2016 and 2017 to 51.1% in 2018 and decrease to 35.4% in 2019. Over the study period, 19.7% (46/234) had at least one positive CT/NG result. After the intervention, case detection per 100 py increased for CT (2016: 2.6, 2017: 3.7, 2018: 7.7, 2019: 7.1) and NG (2016: 3.2, 2017: 3.1, 2018: 5.3, 2019: 7.6). The number needed to test was 8.9 for CT and 10.4 for NG.

Conclusion
Regular CT/NG screening is feasible in a primary care setting, leads to an increase in case detection and may contribute to decrease transmission and complications of CT/NG.

Trial registration
The trial is registered in ClinicalTrials.gov (NCT02149004).
A Homotopic Direct Collocation Approach for Operational-Compliant Trajectory Design
Authors: Mannocchi Alessandra , Giordano Carmine , Topputo Francesco 
Published: November 2022

AbstractStand-alone deep-space CubeSats are the future of the space sector. For limited budget reasons, these spacecraft need to follow operational-compliant (OC) trajectories: transfers with thrusting and coasting periods imposed at pre-defined time instants. Traditional trajectory optimisation algorithms exhibit convergence problems when handling discontinuous constraints. In this work, a homotopic direct collocation approach is presented. It employs a continuation algorithm that maps the classical bang-bang trajectory of a fuel-optimal low-thrust problem into an OC solution. M-ARGO CubeSat mission is considered as case study for validation, including a realistic thruster model with variable specific impulse and maximum thrust. The trajectories computed with the developed algorithm are compared with non-operational-compliant solutions. Our algorithm produces transfers similar to the optimal solutions with no operational constraint, both in terms of thrusting profile and propellant mass.
Psychometric properties of the Italian body shape questionnaire: an investigation of its reliability, factorial, concurrent, and criterion validity
Authors: Marzola Enrica , Martini Matteo , Longo Paola , Toppino Federica , Bevione Francesco , Delsedime Nadia , Abbate-Daga Giovanni , Preti Antonio 
Published: November 2022

Abstract
Purpose
This study was set up to investigate the reliability, factorial, concurrent, and criterion validity of the Italian version of the 34-item Body Shape Questionnaire (BSQ) and its shorter versions.

Methods
The study included 231 patients diagnosed with an eating disorder and 58 putatively healthy people (comparison sample). The Italian BSQ-34 was administered to participants together with the Hamilton Depression Rating Scale and the Hamilton Anxiety Rating Scale. Information on body mass index, caloric intake at baseline, and the number of episodes of self-vomiting per week was also acquired.

Results
Cronbach’s alpha of BSQ-34 was 0.971 (95% confidence interval [CI] 0.965–0.976) in patients and 0.960 (0.944–0.974) in controls. Test–retest stability in patients (n = 69), measured with intraclass correlation coefficient, was 0.987 (0.983–0.991). Confirmatory factor analysis of the single-factor model yielded acceptable fit for all versions of the BSQ. On all BSQ versions, patients scored higher than controls with a large effect size when calculated as Cliff’s delta. BMI and mean caloric intake at baseline had a stronger association with BSQ-34 than levels of anxiety and depression. The analysis with the receiver operating characteristics (ROC) curve showed that the BSQ-34 distinguished patients with an eating disorder from controls with good accuracy (Area Under the Curve = 86.5; 95% CI 82.2–90.7).

Conclusion
The Italian version of the BSQ possesses good psychometric properties, in both the long and the shortened versions, and it can be applied to measure body dissatisfaction for both clinical and research purposes.

Level of evidence
Level III, Evidence obtained from well-designed cohort or case–control analytic studies.
The democratic lessons learned—How experiences of (un-)equal treatment in school influence satisfaction with democracy in later life
Authors: Weiss Julia , Parth Anne-Marie 
Published: November 2022

AbstractPrevious studies have shown that economic and political experiences influence the level of satisfaction with democracy; however, they fail to explain whether these experiences have the same effect for everyone, whether there is interindividual variance and where these differences might be rooted. In this article, we investigate these roots of interindividual variance and base our argument on the observation that early experiences in school are formative and influence the effect of economic and political experiences on satisfaction with democracy. We analyze an original representative dataset on the German population to test how school experiences, more precisely equal treatment in school, interact with economic and political experiences in later life and thereby influence satisfaction with democracy. We find that school experiences play a significant role here. Voting for the governing parties especially increases satisfaction with democracy if respondents were treated equally in school. Similarly, past experiences of unemployment in particular decrease people’s levels of satisfaction with the political system if they were not treated equally in school. The findings highlight that early experiences made in school can have a relevant influence on satisfaction with democracy in later life.
Evaluation of the Food and Drugs Authority, Ghana Regulatory Review Process: Challenges and Opportunities
Authors: Owusu-Asante Mercy , Darko Delese Mimi , Asamoah-Okyere Kwame Dei , Asante-Boateng Samuel , Kermad Adem , Walker Stuart , Salek Sam 
Published: November 2022

Abstract
Purpose
This study aimed to assess the current regulatory review process of the food and drugs authority (FDA) Ghana by identifying key milestones, target timelines, good review practices and quality decision-making practices and evaluating the overall regulatory performance from 2019 to 2021, as well as the challenges and opportunities for improvement.

Methods
The FDA Ghana representatives completed the optimising efficiencies in regulatory agencies (OpERA) questionnaire, including data identifying the milestones and overall approval times for all products registered by the FDA Ghana from 2019 to 2021.

Results
Of the new active substances approved from 2019 to 2021, 91% were biologicals processed by full or abridged reviews pathways. Timelines for these reviews were within authority targets but were longer compared with generics. Of generics approved from 2019 to 2021, 97% were pharmaceuticals processed by the full review pathway, with timelines within authority targets and shorter compared with new active substances. Regardless of the review model used, approval times for new active substances increased from 84 to 355 calendar days 2019–2021 due to the impact of the pandemic. Guidelines, standard operating procedures and review templates were in place and the majority of indicators for good review practices were implemented. Several quality decision-making practices were implemented, although currently there is not a systematic structured approach.

Conclusion
The FDA Ghana monitors regulatory performance and currently meets its target timelines. To achieve World Health Organization Maturity Level 4 status, an electronic tracking system, benefit-risk assessment framework and template and the publication of assessment reports are recommended.
Pythagorean Fuzzy Bonferroni Mean with Weighted Interaction Operator and Its Application in Fusion of Online Multidimensional Ratings
Authors: Yang Yi , Yang Feifan , Chen Jie , Zeng Yangyan , Liu Limei 
Published: November 2022

AbstractAiming at the aggregation problem of online multi-attribute interactive ratings, a decision-making method based on Pythagorean Fuzzy Bonferroni mean with weighted interaction (PFWIBM) operator is developed by mining the advantages of ratings driven decision-making and the quantitative advantages of Pythagorean fuzzy sets on linguistic ratings. First, the shortcomings of existing operators in criterion interactive representation are analyzed, and the improved Bonferroni mean with weighted interaction and its dual operator are defined, which are used to aggregate the membership information and non-membership information under the Pythagorean fuzzy environment, respectively, and then the PFWIBM operator is constructed. Second, a generation method of interaction coefficients embedded in the PFWIBM operator is designed by combining expert knowledge and user ratings to overcome the limitations of the method of relying on subjective setting parameter values. Third, based on the proposed operator and the transformation relationship between Pythagorean fuzzy sets and linguistic ratings, an online multi-dimensional rating aggregation decision-making approach for solving product raking problems is developed. Finally, the proposed method is applied to a passenger car ranking example to show the feasibility of the method, and through some comparative analysis, the advantages of the proposed operator are clarified, and the influence of operator parameters on the decision-making results is analyzed.
DEIA is essential to advance the goals of translational science: Perspectives from NCATS
Authors: Hussain Shadab F. , Vogel Amanda L. , Faupel-Badger Jessica M. , Ho Linda , Akacem Lameese D. , Balakrishnan Krishna , Geiger Rebekah , Gopal-Srivastava Rashmi , Haynes Brittany , Hodges Marcus G. , Isler Tanetta , Mathé Ewy A. , Misquitta Leonie , Sharma Karlie R. , Sid Eric , Zigterman Jamie L. , Burgoon Penny W. 
Published: November 2022

Abstract
The National Center for Advancing Translational Science (NCATS) seeks to improve upon the translational process to advance research and treatment across all diseases and conditions and bring these interventions to all who need them. Addressing the racial/ethnic health disparities and health inequities that persist in screening, diagnosis, treatment, and health outcomes (e.g., morbidity, mortality) is central to NCATS’ mission to deliver more interventions to all people more quickly. Working toward this goal will require enhancing diversity, equity, inclusion, and accessibility (DEIA) in the translational workforce and in research conducted across the translational continuum, to support health equity. This paper discusses how aspects of DEIA are integral to the mission of translational science (TS). It describes recent NIH and NCATS efforts to advance DEIA in the TS workforce and in the research we support. Additionally, NCATS is developing approaches to apply a lens of DEIA in its activities and research – with relevance to the activities of the TS community – and will elucidate these approaches through related examples of NCATS-led, partnered, and supported activities, working toward the Center’s goal of bringing more treatments to all people more quickly.
Un-Meetings as tools for translational idea generation: A semantic content analysis of an Opioid Crisis Un-Meeting
Authors: Yousefi Nooraie Reza , White Robert J. , Steele Scott , Augustine Erika F. , Ossip Deborah J. , Zand Martin S. 
Published: November 2022

Abstract

Background:
Team development and idea generation are key intertwined steps in translational science that need a framework to accommodate unstructured, participatory interactions. To this end, we introduced Un-Meetings to the Clinical and Translational Science Awards (CTSA) Program, innovative events that facilitate cross-disciplinary idea generation and informal discussions between translational scientists, policy makers, community members, advocates, and public health professionals. Here we describe a mixed methods study to characterize the conceptual diversity and clusterization of ideas generated through an Opioid Crisis Un-Meeting.

Methods:
An Un-Meeting targeting translation science approaches to the opioid crisis were hosted at the University of Rochester Center for Leading Innovation and Collaboration (CLIC). We used semantic analysis and conceptual mapping of keywords to analyze how attendee-led idea generation sessions identified topics for breakout discussions.

Results:
One hundred and two individuals from 40 institutions proposed 150 unique ideas that were grouped into 23 breakout sessions. Network analysis showed that diverse pools of experts were bridged by topics addressing the complexities of the opioid crisis. Two clusters emerged: (1) systems, contexts, and community engagement, and (2) technologies, innovations, and treatment advancements.

Conclusions:
The cross-disciplinary nature of topic areas that bridge across thematic communities provide opportunities for CTSA programs to engage and support development of diverse translational teams. Potential opportunities for team building include technological advancements of opioid prevention, treatment, surveillance, systems approaches, and studies focusing on special populations and health disparities. The analysis method here may be useful in identifying naturally emerging teams of experts and community gaps when addressing large problems.
Categorisation of organisation dualities using the Delphi technique
Authors: Biloslavo Roberto , Edgar David Alex , Rusjan Roland 
Published: November 2022

AbstractThis paper presents the case of a non-traditional use of the Delphi method in order to explore organisational duality and reach a consensus on the 23 organisational dualities which allow for a classification into a three-tier organisational policy model (TTOP-model). The expert group was composed of seven experts from the field of management. The process ran for four rounds to reach the final consensus examining 25 dualities and eventually focusing them down to the final 23. In addition to their practical relevance of understanding the dualities, the findings also have implications for both the literature on strategic management and the paradox lens on organisational theory through an understanding of duality in terms of the TTOP model. This research not only advances conversations in strategic management but also helps to increase confidence when adopting the Delphi method for a wider recognition of the method within both interpretivist studies and paradox research.
Black Motherhood Politics in Costa Rica: Diasporic Genealogies and Links to the State
Authors: Muñoz-Muñoz Marianela 
Published: November 2022

AbstractBlack women who seek and win elected office are changing the political landscape in the Americas. In Latin America, this shift became widely recognized when Epsy Campbell Barr became the first Black woman vice president in Costa Rica in 2018. Her election builds on the work of three generations of women whose engagement in formal politics is rooted in their intertwined identities as Black, women, and of West Indian descent. By recovering a racialized, gendered, and ethnicized lineage of community activism, relationships, and networking—which I call “Little’s links” to honor the legacy of the writer and activist Eulalia Bernard Little—I argue that in Costa Rica, Caribbean identity and Black motherhood politics have influenced Black women’s engagement in national politics. This account of these other (and mothers’) political routes to state power for Afro-Caribbean women in Costa Rica complements current explanations of Black women’s participation in national politics elsewhere.
Dietary betaine intake and risk of mortality in patients with coronary artery disease: the prospective Guangdong Coronary Artery Disease Cohort
Authors: Liu Si , Wang Dongjin , Li Bo , Li Kai , Dai Xin , Cheng Lokyu , Wang Jing , Huang Ting , Tang Yue , Xiao Yunjun 
Published: November 2022

AbstractThis study is designed to explore the association between dietary betaine intake and risk of all-cause and cardiovascular death in patients with coronary artery diseases (CAD). In this cohort study, 1292 patients with CAD were followed up for a median of 9·2 years. Baseline dietary betaine intake was collected using a paper-based semi-quantitative FFQ and assessed according to the US Department of Agriculture (USDA) database and the data of betaine in common foods. Cox proportional hazards regression models were used to analyse the association between dietary betaine intake and risks of all-cause and cardiovascular mortality. During the follow-up periods, 259 deaths recorded in 1292 participants, of which 167 died of CVD. Patients in the highest tertile of dietary betaine intake had a lower risk of all-cause (P = 0·007) and cardiovascular death (P < 0·001) than those in the lowest tertile after adjusting for age and sex, traditional cardiovascular risk factors and other potential confounders. After further adjusting for plasma methionine metabolites and vitamins, hazard ratio across tertiles of dietary betaine intake were 1·00, 0·84 and 0·72 for all-cause mortality (Pfor trend = 0·124), and 1·00, 0·77 and 0·55 for cardiovascular mortality (Pfor trend = 0·021). Higher dietary betaine intake was associated with a decreased risk of cardiovascular death after fully adjustment for cardiovascular risk factors, other potential confounders and plasma methionine metabolites and vitamins. However, the association between dietary betaine intake and risk of all-cause mortality was not statistically significant after further adjusting for plasma methionine metabolites and vitamins.