bluuebunny/crossref_metadata_2025_split huggingface dataset:
VEGETATION CHANGES ANALYSIS USING NDVI (NORMALIZED DIFFERENCE VEGETATION INDEX) METHOD IN KALIANDA SUBDISTRICT, LAMPUNG SELATAN DISTRICT, INDONESIA
Authors: Ramadhani Winih Sekaringtyas , Rahmat Ali , Arza Asha Ananda 
Published: February 2022

<div><p class="Els-history-head">Each year, the population in Kalianda subdistrict, Lampung province keeps increasing. The increase in population means that the need for living space also increasing, this can lead to land cover conversion from a vegetation area to a residential area. To find how much the change in land conversion over the year, a spatial analysis over the period of 18 years was needed. So that it is expected to be able to manage spatial planning to cope with disasters in Indonesia. This research uses Landsat 7 and 8 images that have been calculated using the Normalized Difference Vegetation Index (NDVI) method. The results show that between 2010 - 2019, there is an increase in land cover changes in open land/house/building/no vegetation around 814 ha (6.9%), in low vegetation increase 975 ha (8.4%). However, in the medium vegetation was decreasing around 1123 ha (9.5%). Overall observation sample of the ground check is following the actual condition of land cover in Kalianda Sub-district. The data show that in the Kalianda subdistrict, land management is necessary to suppress land cover changes so that it won’t lead to environmental disasters</p></div>
THE ROLE OF THE INDONESIAN MINISTRY OF DEFENSE AGAINST THREATS TO THE AGRICULTURAL SECTOR FROM A NON-MILITARY DEFENSE PERSPECTIVE
Authors: Hidayana Dina , Prihantoro Mitro , Saragih Herlina J.R. 
Published: February 2022

<div><p class="Els-history-head">The agricultural sector is the main element in the food supply, especially to achieve food security, climate change, damage to agricultural infrastructure, land conversion and declining agricultural production are threats in the agricultural sector that are currently occurring both globally and nationally can cause a food crisis. One of the government's efforts to maintain sustainable food availability is the food estate program involving the Ministry of Defense. This study aims to identify the role of the Indonesian Ministry of Defense in overcoming threats to the agricultural sector for the welfare and interests of national defense. This study uses a qualitative method with a literature study approach. The data collection technique is to examine empirical information or data sourced from books, journals, scientific research reports, and other literature that has links to the national defense sector and the agricultural sector, as well as open library materials such as magazines, newspapers, and websites. From the perspective of non-military defense, it can be concluded that the role of defense institutions in overcoming non-military threats, in this case, the threat of a food crisis, is as a form of support capacity in securing national food availability, both production and distribution as well as supporting non-military defense functions in the context of realizing national logistics reserves. To support the implementation of a non-military defense system in agriculture that can maintain the safety of the nation from the threat of a food crisis, it is necessary to empower non-military defense so that it has strong deterrence in preventing all threats that arise.</p></div>
Pengaruh Penerapan Model Moody Terhadap Hasil Belajar Memahami Makna Lirik Lagu Wajib Nasional Pada Siswa Kelas V SD Negeri 1 Sindangbarang Kecamatan Jalaksana Kabupaten Kuningan
Authors: Juhaeriah Juju , Cunandar Dadang 
Published: February 2022

Penelitian ini dilatarbelakangi oleh hasil belajar memahami makna lirik lagu siswa kelas V masih relatif rendah, hal ini berdampak pada rendahnya nilai hasil belajar 22 siswa yaitu sebesar 48,55%, dari jumlah seluruhnya belum mencapai KKM dimana KKM Bahasa Indonesia di SD Negeri 1 Sindangbarang sebagaimana telah ditetapkan yaitu 70. Model Moody dapat dijadikan alternatif yang dapat meningkatkan hasil belajar memahami makna lirik lagu dalam jangka waktu yang lebih panjang. Penelitian ini bertujuan untuk mengetahui Pengaruh Penerapan Model Moody Terhadap Hasil Belajar Memahami Makna Lirik Lagu Wajib Nasional Pada Siswa Kelas V SD Negeri 1 Sindangbarang Kecamatan Jalaksana Kabupaten Kuningan. Desain penelitian ini menggunakan One Group Pretest Posttest Design. Populasi dalam penelitian ini siswa kelas V SD Negeri 1 Sindangbarang yang berjumlah 22 siswa. Pengambilan sampel menggunakan teknik sampling total. Hasil penelitian nilai pretest yaitu 48,55. Hasil penelitian menunjukan terdapat Pengaruh Penerapan Model Moody Terhadap Hasil Belajar Memahami Makna Lirik Lagu Wajib Nasional Pada Siswa Kelas V SD Negeri 1 Sindangbarang Kecamatan Jalaksana Kabupaten Kuningan.
Hubungan Antara Kecerdasan Emosional Dengan Hasil Belajar Kognitif Siswa Kelas IV Pada Semester I Di SDN 2 Cileuya
Authors: Nuraeni Evi , Pramudika Sari Agatha 
Published: February 2022

Penelitian ini merupakan penelitian kuantitatif dengan metode korelasi. Sampel yang digunakan dalam penelitian ini adalah siswa kelas IV SDN 2 Cileuya, semester I tahun pelajaran 2018/2019. Teknik pengumpulan data yang digunakan adalah angket dan studi dokumentasi.. Kecerdasan emosional siswa kelas IV SDN 2 Cileuya termasuk dalam kategori tinggi sebesar 80%. Hal ini dilihat pada kriterium tinggi dengan jarak interval 68% - 100%. Hasil belajar kognitif siswa kelas IV pada semester I di SDN 2 Cileuya memperoleh nilai terendah 723 dengan rata-rata 72,3 nilai tertinggi sebesar 810 dengan rata-rata 81 dan memperoleh ratarata secara keseluruhan sebesar 2419,6 berada diatas nilai Kriteria Ketuntasan Minimal (KKM) yang telah ditetapkan sebesar 70. Hasil perhitungan uji hipotesisi diperoleh thitung (3,136) > ttabel (1,697) (taraf signifikansi 5% dengan dk = 32 – 2 = 30) maka Ho ditolak dan Hi diterima, artinya terdapat hubungan antara kecerdasan emosional dengan hasil belajar kognitif siswa kelas IV pada semester I di SDN 2 Cileuya”. Kesimpulan dalam penelitian ini adalah terdapat hubungan antara kecerdasan emosional dengan hasil belajar kognitif siswa kelas IV pada semester I di SDN 2 Cileuya.
Aleitamento materno e perfil sociodemográfico e obstétrico entre puérperas atendidas em maternidade pública de referência
Authors: Santos Romila Martins de Moura Stabnow , Lima Iara Angélica da Silva , Candido Paula Gabrielle Gomes , Bezerra Janaina Miranda , Pascoal Livia Maia , Santos Neto Marcelino , Santos Floriacy Stabnow 
Published: February 2022

Objetivo: conhecer o histórico do aleitamento materno, o perfil sociodemográfico e obstétrico entre puérperas atendidas em maternidade pública de referência. Metodologia: Estudo em campo, transversal com abordagem quantitativa, desenvolvido entre novembro de 2019 e março de 2020, com 300 puérperas internadas em uma maternidade pública de referência, selecionadas por conveniência. Dados coletados em formulário contendo perguntas acerca de informações sociodemográficas, obstétricas e de amamentação e analisados de forma descritiva considerando as frequências absolutas e relativas das variáveis. Pesquisa aprovada pelo Comitê de Ética em Pesquisa da Universidade Federal do Maranhão sob o protocolo no 3.450.563. Resultados: As puérperas tinham idade entre 18 e 30 anos; 61,0% eram casadas ou em união estável; 72,6% cursaram o Ensino Médio; 65,4% com renda familiar entre 1 e 2 salários mínimos; 76,0% eram donas de casa; 42,7% tinham 2 filhos; 99,7% fizeram pré-natal; 65,4% fizeram seis ou mais consultas; 49,3% foram orientadas sobre a prática da amamentação durante o pré-natal; 76,7% já amamentaram anteriormente; 60,0% não tiveram dificuldades para amamentar e as demais referiram queixa de pouco leite (22,0%), fissura no mamilo (15,4%), se queixaram de ter leite fraco (1,6%) e sentiram dor (1,0%). Conclusão: Evidenciou-se a importância do uso de atividades educativas voltadas para a amamentação pelos profissionais de saúde que prestam assistência ao pré-natal, parto e puerpério, visando contribuir para que as mães tenham condições de amamentar, reduzindo assim as taxas de desmame precoce.
Perception of social and emotional characteristics through smile
Authors: Silva Iara Fonseca Carvalho , Paschoal Marco Aurélio Benini , Nascimento Alexia David , Lago Andréa Dias Neves 
Published: February 2022

Introduction: The concept of beauty, however a subjective issue, is overvalued in some societies, especially in Brazil. Beautiful people enjoy social advantages and are best evaluated for having positive characteristics. Objective: To quantify, by means of a questionnaire, the ability of interviewees, to evaluate / intuit / attribute specific characteristics to unknown people, starting from an observational point of view by means of different photos. Methods: Six different photos were designed for undergraduate students, each representing a smile with different aesthetic changes. Participants answered a questionnaire that contained 10 statements regarding emotional and social characteristics and, afterwards, scoring whether or not they agreed with each statement for each evaluated image. Results: A better evaluation was obtained of image considered having harmonic smile, while greater negative characteristics were attributed to smiles with aesthetic changes, such as fractures, diastema, unsatisfactory restorations, and color changes. Conclusion: According to this study, it can be concluded that dental aesthetics influence the evaluation and judgment of certain characteristics influencing on the emotional and social background. It is the duty of the dental surgeon to be attentive to this subjective step when facing unaestethic smiles, allowing a greater understanding the psycho-social context of the patient.
Avaliação do projeto integrador do curso técnico em agropecuária do IFPA – Campus Breves
Authors: Araújo Haroldo Ferreira de , Oliveira Ivanildo Amorim de , Dias Danielle Rodrigues , Freitas Ludmila de 
Published: February 2022

Frente à importância do Projeto Integrador para os cursos técnicos como uma metodologia de ensino/aprendizagem é necessário avaliar frequentemente seus resultados, a fim de se propor soluções adequadas às exigências acadêmicas. Dessa forma, o objetivo da pesquisa foi avaliar o Projeto Integrador do curso técnico subsequente em agropecuária com alternância pedagógica como uma metodologia de ensino/aprendizagem capaz de integrar a grade curricular do curso a vivência profissional do mercado de trabalho, com proposições para o aprimoramento e melhor desempenho do mesmo. Utilizou-se a pesquisa-ação e da análise qualitativa e quantitativa para o alcance dos resultados. Trabalhou-se com as ferramentas de pesquisa: enquetes e questionários, sendo os mesmos aplicados entre os docentes e discentes do curso com perspectiva de se obter opiniões sobre andamento do Projeto Integrador do curso verificando assim, se seus objetivos estão sendo alcançados. Concluiu-se que a maioria dos professores e alunos do curso concordam que a ferramenta não está a contento para atingir seus reais objetivos, necessitando de uma reestruturação da sua metodologia. Dessa forma, as funções de integrar a grade curricular do curso a vivência profissional do mercado de trabalho, está muito aquém do esperado, tornando-se uma ferramenta pouco interessante para os discentes do curso técnico em agropecuária.
Importancia del COVID-19 en la atención estomatológica
Authors: Funes-Rumiche Italo 
Published: February 2022

La pandemia por COVID-19 representa un reto para los servicios de salud y ha producido un colapso de estos en muchas partes del mundo y el cirujano dentista no ha estado al margen de esta situación y ha jugado un rol importante, produciéndose una serie de cambios y reforzando otros, como las medidas de bioseguridad, para una atención estomatológica segura. En la siguiente revisión de la literatura, se muestra la preponderancia que tiene la cavidad bucal en la enfermedad del COVID-19 tanto en la infectividad y severidad en la presentación de los síntomas. así mismo se discute el riesgo de la labor que cumple el cirujano dentista y cómo nuestra profesión puede ayudar a mitigar los contagios a través de la disminución de la carga viral con el uso de determinados productos tienen una sólida base científica con investigaciones realizadas para demostrar esta acción.
CRISPR/Cas12a-Enhanced Loop-Mediated Isothermal Amplification for the Visual Detection of Shigella flexneri
Authors: Shi Yaoqiang , Kang Lan , Mu Rongrong , Xu Min , Duan Xiaoqiong , Li Yujia , Yang Chunhui , Ding Jia-Wei , Wang Qinghua , Li Shilin 
Published: February 2022

Shigella flexneri is a serious threat to global public health, and a rapid detection method is urgently needed. The CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated) system is widely used in gene editing, gene therapy, and in vitro diagnosis. Here, we combined loop-mediated isothermal amplification (LAMP) and CRISPR/Cas12a to develop a novel diagnostic test (CRISPR/Cas12a-E-LAMP) for the diagnosis of S. flexneri. The CRISPR/Cas12a-E-LAMP protocol conducts LAMP reaction for S. flexneri templates followed by CRISPR/Cas12a detection of predefined target sequences. LAMP primers and sgRNAs were designed to the highly conserved gene hypothetical protein (accession: AE014073, region: 4170556–4171,068) of S. flexneri. After the LAMP reaction at 60°C for 20 min, the pre-loaded CRISPR/Cas12a regents were mixed with the LAMP products in one tube at 37°C for 20 min, and the final results can be viewed by naked eyes with a total time of 40 min. The sensitivity of CRISPR/Cas12a-E-LAMP to detect S. flexneri was 4 × 100 copies/μl plasmids and without cross-reaction with other six closely related non-S. flexneri. Therefore, the CRISPR/Cas12a-E-LAMP assay is a useful method for the reliable and quick diagnosis of S. flexneri and may be applied in other pathogen infection detection.
BCL2A1 and CCL18 Are Predictive Biomarkers of Cisplatin Chemotherapy and Immunotherapy in Colon Cancer Patients
Authors: Yue Taohua , Liu Xiangzheng , Zuo Shuai , Zhu Jing , Li Jichang , Liu Yucun , Chen Shanwen , Wang Pengyuan 
Published: February 2022

Background: Cisplatin enhances the antitumor T cell response, and the combination of PD-L1 blockade produces a synergistic therapeutic effect. However, the clinical correlation between cisplatin and immunotherapy in colon cancer (CC) is unknown.Methods: Using the “pRRophetic” package, we calculated the IC50 of cisplatin. The correlation between cisplatin IC50, cisplatin resistance–related genes (CCL18 and BCL2A1), and immunotherapy were preliminarily verified in TCGA and further validated in independent cohorts (GSE39582 and GSE17538), cisplatin-resistant CC cell line DLD1, and our own clinical specimens. Classification performance was evaluated using the AUC value of the ROC curve. Scores of immune signatures, autophagy, ferroptosis, and stemness were quantified using the ssGSEA algorithm.Results: Based on respective medians of three CC cohorts, patients were divided into high- and low-IC50 groups. Compared with the high IC50 group, the low-IC50 group had significantly higher tumor microenvironment (TME) scores and lower tumor purity. Most co-signaling molecules were upregulated in low IC50 group. CC patients with good immunotherapy efficacy (MSI, dMMR, and more TMB) were more attributable to the low-IC50 group. Among seven shared differentially expressed cisplatin resistance–related genes, CCL18 and BCL2A1 had the best predictive efficacy of the above immunotherapy biomarkers. For wet experimental verification, compared with cisplatin-resistant DLD1, similar to PD-L1, CCL18 and BCL2A1 were significantly upregulated in wild-type DLD1. In our own CC tissues, the mRNA expression of CCL18, BCL2A1, and PD-L1 in dMMR were significantly increased. The high group of CCL18 or BCL2A1 had a higher proportion of MSI, dMMR, and more TMB. IC50, CCL18, BCL2A1, and PD-L1 were closely related to scores of immune-related pathways, immune signatures, autophagy, ferroptosis, and stemness. The microRNA shared by BCL2A1 and PD-L1, hsa-miR-137, were significantly associated with CCL18, BCL2A1, and PD-L1, and downregulated in low-IC50 group. The activity of the TOLL-like receptor signaling pathway affected the sensitivity of CC patients to cisplatin and immunotherapy. For subtype analysis, immune C2, immune C6, HM-indel, HM-SNV, C18, and C20 were equally sensitive to cisplatin chemotherapy and immunotherapy.Conclusions: CC patients sensitive to cisplatin chemotherapy were also sensitive to immunotherapy. CCL18 and BCL2A1 were novel biomarkers for cisplatin and immunotherapy.
Mercury Isotopes in Shale Gas From Wufeng-Longmaxi Shale Formation of Sichuan Basin, Southern China: A Preliminary Investigation
Authors: Tang Shunlin , Ding Yuxiang , Zhu Guangyou , Feng Xinbin , Zhang Huaishun , Li Penggao 
Published: February 2022

A series of investigations have been conducted concerning the study of traditional stable isotopes and rare gas stable isotopes in natural gas. However, little is known regarding non-traditional stable isotopes of mercury in natural gas, especially in the development and utilization of shale gas in recent years. In fact, the presence of mercury in natural gas (including shale gas) provides a basis for research on mercury isotopes. Mercury was extracted from shale gas at the Wufeng-Longmaxi Formation in the YS108 block of the Zhaotong National shale gas demonstration area in the Sichuan Basin by using an acid potassium permanganate solution, followed by the analysis of mercury content and stable isotope composition. The mercury content in the marine shale gas at the Wufeng-Longmaxi Formation ranged from 171 to 2,906 ng/m3, with an average of 1,551.08 ± 787.08 ng/m3 (n = 37, 1 SD). The Δ199Hg values of mercury stable isotopes range from 02‰ to 0.39‰, with an average of 22‰ ± 0.08‰ (n = 37, 1 SD); the δ202Hg values range from −1.68‰ to −0.04‰, with an average of −0.87‰ ± 0.31‰ (n = 37, 1 SD), which are significantly different from the Δ199Hg and δ202Hg information of coalbed gas, but similar to the Δ199Hg and δ202Hg information of terrestrial oil-type gas and the Δ199Hg in the main hydrocarbon-forming organic matter of lower organisms such as algae (t-test, p &gt; 0.05). This indicates that terrestrial target strata with abundant algae or strata with positive Δ199Hg are the target strata for the exploration of terrestrial oil and gas.
The Role of Lactate Exercise Test and Fasting Plasma C-Peptide Levels in the Diagnosis of Mitochondrial Diabetes: Analysis of Clinical Characteristics of 12 Patients With Mitochondrial Diabetes in a Single Center With Long-Term Follow-Up
Authors: Zhao Yuan , Zhang Ying , Qi Mengya , Ping Fan , Zhang Huabing , Xu Lingling , Li Wei , Li Yuxiu 
Published: February 2022

ObjectiveThe aim of this study was to analyze the clinical characteristics and the pattern of long-term changes of fasting plasma C-peptide in patients with mitochondrial diabetes (MD), and to provide guidance for the diagnosis and treatment of MD.MethodsWe retrieved MD patients with long-term follow-up at Peking Union Medical College Hospital from January 2005 to July 2021 through the medical record retrieval system and retrospectively analyzed their clinical data, biochemical parameters, fasting plasma C-peptide, glycosylated hemoglobin and treatment regimens. Non-parametric receiver operating characteristic (ROC) curves were used to assess the relationship between exercise test-related plasma lactate levels and suffering from MD.ResultsA total of 12 MD patients were included, with clinical characteristics of early-onset, normal or low body weight, hearing loss, maternal inheritance, and negative islet-related autoantibodies. In addition, patients with MD exhibited significantly higher mean plasma lactate levels immediately after exercise compared to patients with type 1 diabetes mellitus (T1DM) (8.39 ± 2.75 vs. 3.53 ± 1.47 mmol/L, p=0.003) and delayed recovery time after exercise (6.02 ± 2.65 vs. 2.17 ± 1.27 mmol/L, p=0.011). The optimal cut-off points identified were 5.5 and 3.4 mmol/L for plasma lactate levels immediately after and 30 minutes after exercise, respectively. The fasting plasma C-peptide levels decreased as a negative exponential function with disease progression (Y= 1.343*e-0.07776X, R2 = 0.4154). Treatment regimens in MD patients were varied, with no metformin users and a weak correlation between insulin dosage and body weight.ConclusionsThe increased level of plasma lactate during exercise or its delayed recovery after exercise would contribute to the diagnosis of MD. Changes of fasting plasma C-peptide in MD patients over the course of the disease indicated a rapid decline in the early stages, followed by a gradual slowing rate of decline.
The Effect of PPARγ rs1801282 Variant on Mortality Risk Among Asians With Chronic Kidney Disease: A Cohort Study and Meta-Analysis
Authors: Chen Wei-Teing , Chiu Chih-Chien , Tsai Dung-Jang , Ko Pi-Shao , Lee Meng-Chang , Lin Hsiao-Ting , Chen Ying-Kai , Su Wen , Lin Yuh-Feng , Su Sui-Lung 
Published: February 2022

Background: Chronic kidney disease (CKD) is a public health issue, and an independent risk factor for cardiovascular disease. The peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the cardiovascular system. Previous studies have examined one important exon polymorphism, Pro12Ala, in PPARG with respect to mortality of CKD patients, but the results were inconsistent and current evidence is insufficient to support a strong conclusion. This study aimed to examine the correlation between Pro12Ala gene polymorphism and mortality among Asians with CKD by trial sequential analysis (TSA).Methods: The research was divided into observational research and meta-analysis. For the cohort study, 767 subjects from dialysis centers in Taipei were selected as samples, and tracked from December 2015 to February 2017. For the meta-analysis, relevant literature from “PubMed” and “Embase” databases (until December 2016), was searched and TSA was used to verify the results. In order to achieve the best evidence hierarchies, our retrospective cohort study was added to the meta-analysis and the TSA.Results: The combined sample size for Asian was 1,685 after adding our cohort study, and there was no significant correlation between PPARG Pro12Ala and mortality by the allele model (RR: 0.85, 95% CI: 0.39–1.83, I2 = 79.3%). Under the parameter setting with the RR value of 1.5, TSA estimation presented that the cumulative sample size entered into the futility area, and it confirmed the conclusion in this study.Conclusion: We found that PPARG Pro12Ala gene polymorphism was not related to mortality in CKD Asians patients, and validated our conclusion using TSA after adding our sample.