bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entropy analysis in a second‐grade nanoliquid influenced by an exponential space‐dependent heat source and Arrhenius activation energy
Authors: Subbarao K. , Elangovan K. , Gangadhar Kotha 
Published: April 2022

AbstractAddressing the second‐grade nanofluid flow over a porous stretching sheet based on entropy generation is done in this study. In the mathematical modeling, the revised Buongiorno model is utilized. Employing exponential space‐dependent heat generation and Heat transfer subject to melting effect is implemented. Energy and concentration expressions are retained based on the impact of activation energy, Joule heating, nonlinear thermal radiation, and viscous dissipation. Implementation of solutions for a standard transformation, governing equations, and the numerical procedure is done. Several governing parameters are discussed based on the effect of comprehensive effects of the flow region. A thicker thermal boundary layer is obtained by increasing the magnetic strength and Brownian movement. Thermophoresis increases similarly while the trend takes place, and for the melting parameter, the reverse order is noted. Melting parameter increases with increase in entropy generation rate and Brinkman number increases with reduction in Bejan number. In the literature, it is found that the situation is limited for the obtained results in the model. Higher entropy generation rates are exhibited for the demonstration of magnetic force. From the results, it is observed that the design parameters will consequently optimize the heat transfer in the assessment of industrial processes.
Towards a metabolomic approach to investigate iron–sulfur cluster biogenesis
Authors: Marengo Mauro , Fissore Alex , Oliaro‐Bosso Simonetta , Adinolfi Salvatore , Pastore Annalisa 
Published: April 2022

AbstractIron–sulfur clusters are prosthetic groups that are assembled on their acceptor proteins through a complex machine centered on a desulfurase enzyme and a transient scaffold protein. Studies to establish the mechanism of cluster formation have so far used either in vitro or in vivo methods, which have often resulted in contrasting or non‐comparable results. We suggest, here, an alternative approach to study the enzymatic reaction, that is based on the combination of genetically engineered bacterial strains depleted of specific components, and the detection of the enzymatic kinetics in cellular extracts through metabolomics. Our data prove that this ex vivo approach closely reproduces the in vitro results while retaining the full complexity of the system. We demonstrate that co‐presence of bacterial frataxin and iron is necessary to observe an inhibitory effect of the enzymatic activity of bacterial frataxin. Our approach provides a new powerful tool for the study of iron–sulfur cluster biogenesis.
Impact of SARS‐CoV‐2 Mu variant on vaccine effectiveness: A comparative genomics study at the peak of the third wave in Bogota, Colombia
Authors: Ramirez Angie L. , Luna Nicolas , Patiño Luz H. , Castañeda Sergio , Muñoz Marina , Ballesteros Nathalia , Perez Julie , Correa‐Cárdenas Camilo A. , Duque Maria Clara , Mendez Claudia , Oliveros Carolina , Paniz‐Mondolfi Alberto E. , Ramírez Juan David 
Published: April 2022

AbstractWe assessed the circulation of severe acute respiratory syndrome coronavirus‐2 variants amongst vaccinated military personnel in Bogotá, Colombia to evaluate the mutations of certain variants and their potential for breakthrough infection in vaccinated subjects. We observed that in vaccinated individuals the most frequent infecting lineage was Mu (B.1.621 and B.1.621.1). The above is possibly associated with specific mutations that confer it with vaccine‐induced immune escape ability. Our findings highlight the importance of how genomic tracking coupled with epidemiological surveillance can assist in the study of novel emerging variants (e.g., Omicron) and their impact on vaccination efforts worldwide.
Combining Raman spectroscopy and synchrotron X‐ray diffraction to unveil the order types in A3CaNb2O9 (A = Ba, Sr) complex perovskites
Authors: Rodrigues João Elias F. S. , Costa Renilton C. , Pizani Paulo S. , Hernandes Antonio C. , Alonso José A. 
Published: April 2022

AbstractThe structural ordering process in complex perovskites has a pivotal role for tuning many physical properties for broad applications, ranging from microwave technology, proton‐conduction, multiferroicity, and so on. Therefore, the characterization of order type in these materials is essential for designing new devices with high‐performance. Here, the coexistence of B‐site 1:1 and 1:2 order types in mixed ordered A3CaNb2O9 (A = Ba, Sr) perovskite was investigated by combining Raman spectroscopy and high‐resolution synchrotron X‐ray powder diffraction. High‐wavenumber interval 700–825 cm−1 exhibits two bands concerning the symmetric breathing modes of [NbO6] octahedra in A3CaNb2O9, which were ascribed to the 1:1 and 1:2 domain regions in coexistence. This model was fully corroborated using two phases for describing the synchrotron X‐ray pattern of the Ba3CaNb2O9 sample. Therefore, the Raman spectroscopy can be indeed applied as a rapid tool for probing the achievement of ordered, partially ordered, or disordered structures in complex perovskites. For the first time, BaLaCaNbO6 was synthesized and structural characterized, being indexed by the monoclinic unit cell belonging to the space group
.
Influence of Grading on Management and Outcome in Mucoepidermoid Carcinoma of the Parotid—A Multi‐institutional Analysis
Authors: Grasl Stefan , Janik Stefan , Faisal Muhammad , Grasl Matthaeus C. , Pammer Johannes , Weinreb Ilan , Fischer Gregor , Kim John , Hosni Ali , de Almeida John R. , Goldstein David P. , Erovic Boban M. 
Published: April 2022

ObjectiveTo evaluate clinical outcome of low (G1), intermediate (G2), and high‐(G3) grade mucoepidermoid carcinomas (MEC) of the parotid gland.Study DesignRetrospective chart review including 212 patients. Clinicopathological data was statistically analyzed regarding grading, overall survival (OS), disease‐free survival (DFS) and disease‐specific survival (DSS).Results105 (49.5%) G1, 73 (34.5%) G2, and 34 (16%) G3 MEC were included and 56 (26.4%) patients presented with neck node metastases. The risk of occult nodal metastases was significantly associated with grading and increased from 9.2% in G1 to 26.7% and 27.8% in G2 and G3 tumors, respectively (p = 0.008). Elective periparotid and cervical lymph node dissection was performed in 170 (80.2%) and 70 (33%) patients, respectively. All patients with positive periparotid nodes when subjected to an additional neck dissection had associated cervical neck node involvement (p < 0.001). Grading was an independent significant prognostic factor for OS (HR 4.05; 95%CI: 1.15–14.35; p = 0.030) and DSS (HR 17.35; 95%CI: 1.10–273.53; p = 0.043). In a subgroup analysis, elective neck dissection (END) was also significantly associated with a better DFS (p = 0.041) in neck node‐negative G1 MECs.ConclusionThe risk of occult nodal metastasis in intermediate‐grade MEC is as high as in high‐grade MEC and that END in G1 tumors is associated with a prolonged DFS. Additionally, periparotid node involvement seems to be a predictor for positive neck node involvement. This study presents some preliminary data to consider END in clinically neck node negative patients with parotid MEC; however, larger series are needed.Level of Evidence3 Laryngoscope, 133:124–132, 2023
A parallel universe: Challenges for an international journal based in Russia
Authors: Rushby Nick 
Published: April 2022

Key points
Editing a Russian journal revealed differences in scientific behaviour, particularly around plagiarism.
All editorial efforts to develop a high quality journal can be rapidly dismantled by external forces and world politics.
The Ukrainian invasion is likely to return Russian science to the isolation of 40 years ago.
The ability of journals to operate independently is heavily influenced by national and international politics which pose an existential threat to journals.
Academic journals can be used as a means of exercising soft political power and the ability of editors to circumnavigate or challenge this are severely limited.
APPLYING THE SUCCESS FACTOR FOR ORGANIZATIONAL LEADERSHIP
Authors: Gotian Ruth 
Published: April 2022

AbstractThe author details the results of many years studying high achievers in a variety of fields, including conducting more than 100 interviews, both in person and remotely. The group of interviewees included chief executive officers/CEOs, Olympic and NBA/National Basketball Association athletes, astronauts, and Nobel Prize winners. The results are in the author’s new book The Success Factor, and the findings are abstracted here. The four mindsets (not habits) common to all are intrinsic motivation, work ethic, strong foundation, and continuous Learning through informal learning. These high achievers are incredibly important to an organization. She writes that “High achievers produce 400% more than an average employee, as noted by researchers Ernest O’Boyle Jr. and Herman Aguinis, in a 2012 Personnel Psychology article, yet are given the least attention.” She also describes senior, junior, and peer mentors, as well as group mentoring. Some leadership lessons from this research, in her words are, Offer opportunities for exposure, provide autonomy, create advancement pathways, and offer further training. The author concludes that “knowing how to cultivate and lead these top performers will make your organization the go‐to place for those who wish to be supported on their ascension to success.”
LEADING THROUGH MANAGEMENT AS A LIBERAL ART
Authors: Linkletter Karen 
Published: April 2022

AbstractThe author, who studied under Peter Drucker, is Research Director of the Management as a Liberal Art Research Institute. The organization’s roots are in Drucker’s construct of Management as a Liberal Art, which is described in detail. The author contends that “Drucker’s process of seeing discrete, disruptive events as part of a larger picture or process can be an incredibly useful tool to leaders, particularly in our current challenging times.” Within these MLA principles, four areas in particular are discussed, which in the author’s words are: The Human Dimension, Legitimate Power and Authority, Values, and Balancing Change and Continuity. She also discusses four current organizational challenges within this context; in her words: Labor/Staffing Challenges, Need for Flexibility, Changing Values, and Productivity Challenges. Table 1, MLA Principles and Practices, includes recommendations for today’s leaders (in her words): Avoid drastic and rapid change, Take a step back and look at the forest, Foster a culture of trust in climate of pivoting, Revisit personal and organizational values, and Rethink technology and productivity. Context remains important. As she writes, “Although the pandemic created enormous turmoil in labor markets across the globe, there is evidence that worker supply problems began before any lockdowns and re‐openings.”
Phosphorus‐Containing Fluoro‐Sulfonated Polytriazole Membranes with High Proton Conductivity: Understanding Microstructural and Thermomechanical Behaviors as a Function of Degree of Sulfonation
Authors: Ghorai Arijit , Banerjee Susanta 
Published: April 2022

AbstractThe current article describes the design and synthesis of a new series of phosphorus‐containing fluoro‐sulfonated polytriazoles through click polymerization. The synthesized copolytriazoles (PTPFDSH‐70 to 90) with different degrees of sulfonation (DS) from 70% to 90% are structurally interpreted by various spectroscopic techniques (1H, 13C, and FTIR). The high molecular weight (weight average molecular weight as high as 77 500 g mol−1 with polydispersity index of 2.29) polymers exhibits excellent mechanical (elongation at break up to 95%), thermal (10% decomposition temperature: 266–317 °C), and oxidative (>14.5 h) stability. The PTPFDSH‐70 to 90 possess outstanding water‐holding ability in hydrated conditions (swelling ratio [in‐plane]: 6.2–7.3% at 80 °C). The microstructural alterations by their thermal relaxations and transitions with increasing DS in the polymers have been thoroughly investigated by dynamic mechanical analysis. The atomic force microscopy and transmission electron microscope images of the PTPFDSH‐70 to 90 polymer membranes demonstrated the phase segregated interconnected ionic cluster‐like morphology between hydrophilic and hydrophobic domains. The PTPFDSH‐90 (DEB:PFAZ:DSAZ = 100:10:90) polymer membrane displays the proton conductivity (176 and 190 ms cm−1 at 80 and 90 °C, respectively) higher than Nafion117 under similar test conditions.
Matching ICD‐11 personality status to clinical management in a community team—The Boston (UK) Personality Project: Study protocol
Authors: Jha Mithilesh , Barrett Barbara , Brewin Chris , Bowker Geoff , Harwood Nick , Jalil Iram , Crawford Mike , Phull Jaspreet , Allen Katherine , Duggan Conor , Yang Min , Tyrer Peter 
Published: April 2022

AbstractEpidemiological studies show 30% to 50% of all patients in community mental health teams have personality disorders. These are normally comorbid with other psychiatric disorders, often as Galenic syndromes, and are seldom identified. In the Boston (UK) Personality Project all patients under a community health service in Boston in Lincolnshire will be asked to agree to have their personality status assessed using scales recording the new ICD‐11 classification, together with clinical ratings, social function and satisfaction. A control group of 100 patients from an adjacent service of similar demographics (Spalding) will also have similar ratings but no personality assessments. Changes in clinical status, social function and service satisfaction will be made after 6 and 12 months in both groups. The patients in the Boston group will be offered matched interventions using a stepped care approach for both the severity of disorder and its domain structure. These interventions will include shorter versions of existing psychological treatments, environmental therapies including nidotherapy, adaptive and acceptance models, drug reduction and social prescribing. Full costs of psychiatric care will be measured in both groups. The main hypothesis is that greater awareness of personality function will lead to better clinical outcomes and satisfaction.
Multiscale MD simulations of wild‐type and sickle hemoglobin aggregation
Authors: Olagunju Maryam O. , Loschwitz Jennifer , Olubiyi Olujide O. , Strodel Birgit 
Published: April 2022

AbstractSickle cell disease is a hemoglobinopathy resulting from a point mutation from glutamate to valine at position six of the β‐globin chains of hemoglobin. This mutation gives rise to pathological aggregation of the sickle hemoglobin and, as a result, impaired oxygen binding, misshapen and short‐lived erythrocytes, and anemia. We aim to understand the structural effects caused by the single Glu6Val mutation leading to protein aggregation. To this end, we perform multiscale molecular dynamics simulations employing atomistic and coarse‐grained models of both wild‐type and sickle hemoglobin. We analyze the dynamics of hemoglobin monomers and dimers, study the aggregation of wild‐type and sickle hemoglobin into decamers, and analyze the protein–protein interactions in the resulting aggregates. We find that the aggregation of sickle hemoglobin is driven by both hydrophobic and electrostatic protein–protein interactions involving the mutation site and surrounding residues, leading to an extended interaction area and thus stable aggregates. The wild‐type protein can also self‐assemble, which, however, results from isolated interprotein salt bridges that do not yield stable aggregates. This knowledge can be exploited for the development of sickle hemoglobin‐aggregation inhibitors.
Distributed fixed‐time optimization for multi‐agent systems with time‐varying objective function
Authors: Li Yue , He Xing , Xia Dawen 
Published: April 2022

AbstractIn this article, a distributed time‐varying convex optimization problem for multi‐agent systems is studied. The goal of this article is to use only the local information and interaction information of each agent to drive all agents to achieve consensus and minimize the time‐varying global objective function within a fixed time. In order to solve this problem, a centralized fixed‐time algorithm based on predictive correction method is proposed, which can optimize the time‐varying global objective function based on global information within a fixed time. Then, based on the distributed average tracking method, the centralized algorithm is improved to a distributed fixed‐time algorithm based on local information. The theoretical analysis ensures that the algorithms in this article can solve the time‐varying optimization problem in a fixed time, and numerical examples are proposed to verify the effectiveness of algorithms. Finally, the distributed algorithm is applied to solve battery packages problem.
Clinicopathologic and imaging features of a primary poorly differentiated extradural haemangiosarcoma with polyostotic vertebral involvement and pulmonary metastases in a dog
Authors: O'Byrne Kadie Leanne , Stent Andrew , Tauro Anna 
Published: April 2022

AbstractAn 8‐year‐old, Staffordshire bull terrier was referred for a progressive 8‐week history of left pelvic limb paresis, postural reaction deficits, perineal hypoalgesia and lumbosacral pain. Magnetic resonance imaging revealed a L5–Cd1 circumferential T1‐weighted isointense, T2‐weighted/short Tau inversion recovery hyperintense extradural mass, causing severe spinal cord compression with multifocal lesions of L5–L7 vertebral bodies and extension to paraspinal musculature. Unlike previous reports, both vertebral and epidural lesions showed heterogeneous contrast enhancement, while adjacent paraspinal musculature showed mild ill‐defined enhancement. Computed tomography revealed pulmonary metastases and excluded primary lesion elsewhere. An epidural neoplasm with polyostotic vertebral involvement and pulmonary metastases was suspected. Dorsal laminectomy allowed for decompression and excisional biopsy confirming a diagnosis of poorly differentiated haemangiosarcoma. Haemangiosarcoma should be considered as a differential for primary extradural spinal neoplasia.
Interfacially responsive electron transfer and matter conversion by polydopamine‐mediated nanoplatforms for advancing disease theranostics
Authors: Wang Lu , Zhang Tingting , Xing Yuxin , Wang Zhenqiang , Xie Xiyue , Zhang Jixi , Cai Kaiyong 
Published: April 2022

AbstractPolydopamine (PDA) is an artificial melanin polymer that has been spotlighted due to its extraordinary optoelectronic characteristics and advance theranosctic applications in biomaterial fields. Moreover, interactions on the nano–bio interface interplay whereby substances exchange in response to endogenous or exogenous stimuli, and electron transfer driven by light, energy‐level transitions, or electric field greatly affect the functional performance of PDA‐modified nanoparticles. The full utilization of potential in PDA's interfacial activities, optoelectrical properties and related responsiveness is therefore an attractive means to construct advanced nanostructures for regulating biological processes and metabolic pathways. Herein, we strive to summarize recent advances in the construction of functional PDA‐based nanomaterials with state‐of‐the‐art architectures prepared for modulation of photoelectric sensing and redox reversibility, as well as manipulation of photo‐activated therapeutics. Meanwhile, contributions of interfacial electron transfer and matter conversion are highlighted by discussing the structure–property‐function relationships and the biological effects in their featured applications including disease theranostics, antibacterial activities, tissue repair, and combined therapy. Finally, the current challenges and future perspectives in this emerging research field will also be outlined. Recent advances on polydopamine‐based nanotherapeutics with an emphasis on their interfacial activities, optoelectrical properties and related responsiveness are reviewed for providing insightful guidance to the rational design of integrated theranostic nanoplatforms with high performance in the biomedical fields.This article is categorized under:
Diagnostic Tools > Diagnostic Nanodevices
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Fazit
Authors: Logeswaran Araththy 
Published: April 2022

ZusammenfassungEingangs wurde mehrfach für eine eigene Studie mit dem Schwerpunkt auf Professionellen und ihren Diskriminierungserfahrungen plädiert. Während vorhandene Studien meist nur randständig Diskriminierungserfahrung behandeln oder nicht differenziert genug an den Forschungsgegenstand herangehen, schließt die eigene Arbeit eine Forschungslücke. Sowohl quantitative als auch qualitative Studien haben mit Ausnahme der Arbeit von Mai (2020) die Zielgruppe der Fachkräfte mit Diskriminierungserfahrung bislang nicht umfassend beachtet.
Effective Leptophilic WIMPs at the e+e− collider
Authors: Barman Basabendu , Bhattacharya Subhaditya , Girmohanta Sudhakantha , Jahedi Sahabub 
Published: April 2022

Abstract
We consider higher-dimensional effective (EFT) operators consisting of fermion dark matter (DM) connecting to Standard Model (SM) leptons upto dimension six. Considering all operators together and assuming the DM to undergo thermal freeze-out, we find out relic density allowed parameter space in terms of DM mass (mχ) and New Physics (NP) scale (Λ) with one loop direct search constraints from XENON1T experiment. Allowed parameter space of the model is probed at the proposed International Linear Collider (ILC) via monophoton signal for both Dirac and Majorana cases, limited by the centre-of-mass energy $$ \sqrt{s} $$

s

=1 TeV, where DM mass can be probed within $$ {m}_{\chi }<\frac{\sqrt{s}}{2} $$

m
χ

<

s

2

for the pair production to occur and Λ >$$ \sqrt{s} $$

s

for the validity of EFT framework.
Axion isocurvature collider
Authors: Lu Shiyun 
Published: April 2022

AbstractCosmological colliders can preserve information from interactions at very high energy scale, and imprint them on cosmological observables. Taking the squeezed limit of cosmological perturbation bispectrum, information of the intermediate particle can be directly extracted from observations such as cosmological microwave background (CMB). Thus cosmological colliders can be powerful and promising tools to test theoretical models. In this paper, we study extremely light axions (including QCD axions and axion-like-particles), and consider them constituting cold dark matter (CDM) at late times. We are interested in inflationary isocurvature modes by such axions, and try to figure out how axion perturbations can behave as isocurvature colliders. We work out an example where the intermediate particle is a boson, and show that, in the squeezed limit, it is possible to provide a clock signal of significant amplitudes, with a characteristic angular dependence. This provides a channel to contribute and analyze clock signals of isocurvature bispectrum, which we may hopefully see in future experiments.