bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parametric mapping CMR for the measurement of inflammatory reactions of the pericardium
Authors: Gastl Mareike , Sokolska Justyna M , Polacin Malgorzata , Gotschy Alexander , von Spiczak Brzezinski Jochen , Alkadhi Hatem , Kozerke Sebastian , Manka Robert 
Published: May 2022

ObjectivesAlthough cardiovascular magnetic resonance (CMR) is increasingly used to diagnose pericardial inflammation, imaging can still be challenging using conventional CMR techniques. Parametric mapping (T1/T2 mapping) techniques have emerged as novel methods to quantify focal and global changes of the myocardium without contrast agent. The aim of the present study was to implement parametric mapping to facilitate diagnostic decision-making in pericardial inflammation.MethodsTwenty patients with pericardial inflammation underwent CMR (1.5T system) including T1-weighted/T2-weighted imaging, T1/T2 mapping and late gadolinium enhancement. T1/T2 mapping was performed in end-diastole covering three short-axis slices. Diagnosis of pericardial inflammation was made according to recent guidelines. T1/T2 measurements were pursued by manually drawing regions of interest (ROIs) in the thickened, diseased pericardium carefully avoiding contamination by other cardiac structures. Parametric values were correlated to further markers of pericardial inflammation, such as pericardial thickening and inflammatory parameters.ResultsOn average, the pericardium displayed a thickness of 4.8±1.0 mm. Mean T1 value was 1363.0±227.1 ms and T2 value was 123.3±52.6 ms, which were above patient’s myocardial values (myocardial T1: 998.7±81.0 ms, p<0.001, median 1014.46 ms; T2: 68.0±28.9 m,p<0.001) and the values of a group of four patients with chronic pericarditis (T1: 953.0±16.7 ms; T2: 63.2±10.1 ms). T1 and T2 showed a correlation to the extent of the thickened pericardium (R=0.64, p=0.002 for T1, R=0.72, p=0.005 for T2). There was no correlation of pericardial T1/T2 to blood markers of inflammation, myocardial injury (C reactive protein, troponin, creatine kinase) or further CMR parameters.ConclusionsIn patients with pericardial inflammation, parametric mapping showed elevated T1 and T2 values. Parametric mapping may help to facilitate diagnosis of pericardial inflammation if conventional parameters such as pericardial hyperintensity in T1-weighted or T2-weighted imaging or contrast agent uptake are heterogeneous.
Two new varieties of Russula Pers. (Basidiomycota: Russulaceae) from Sal forests of Shiwaliks, India
Authors: Jitender Kumar  , Narender Singh Atri  
Published: May 2022

This paper deals with two new varieties of Russula species, R. camarophylla var. reticulospora var. nov. and R. aurea var. minuta var. nov. These were collected from the Shiwalik range of northwestern India, in association with Shorea robusta. Russula aurea var. minuta differs from R. aurea in having small sized sporophores, dentate to wavy gill edges with golden or yellow deposition instead of smooth and much smaller spores. Whereas, mushroom R. camarophylla var. reticulospora is close to Russula camarophylla except for the larger carpophores that have white cream pileus surface and larger spores. In basidiospores warts are connected to form mostly complete reticulum instead of mostly isolated warts reported in Russula camarophylla. In view of the presence of some unique varied features in the presently examined collections two new varieties of Russula has been proposed.
Rhodiola yushuensis, a new species of Rhodiola (Crassulaceae) from Qinghai, China
Authors: RONG YU-LIN , LI GUO-DONG , ZHENG HAI-LEI , ZHANG JUN , MENG SHI-YONG 
Published: May 2022

A new species from the Qinghai-Tibetan Plateau is described and illustrated. Rhodiola yushuensis S.Y. Meng et J. Zhang sp. nov. is similar to Rhodiola smithii (Hamet) S. H. Fu, but it differs in its inner caudex leaves with obvious petioles and the leaf blades are obovate-triangular (vs. inner caudex leaves with strongly descends to the base of the petiole, and the leaves are long linear) and the outer caudex leaves are scalelike, triangular-suborbicular (vs. scalelike, narrowly triangular). Principal component analysis (PCA) analysis of the leaf traits and seed coat architecture also showed that R. yushuensis can be separated from R. smithii. The nrDNA internal transcribed spacer (ITS) sequences also support the claim that this plant is a new species, and it is grouped with R. smithii.
Mechanistic analysis of erectile dysfunction in a depression rat model
Authors: Hong Zhi-ming , Chen Zi-long , Feng Jun-long , Wang Sheng-jie , Qiu Jun-feng , Zeng Yang-ling , Wang Quan , Wang Ji-sheng 
Published: May 2022

Objective Most men suffering from depression have different degrees of erectile dysfunction (ED), but the relationship between depression and ED is not clear. This study explored the effect of depression on erectile function in rats and the underlying mechanism. Methods The potential targets and key signaling pathways of depression and ED were predicted through bioinformatics analysis, and a depression rat model was established by inducing chronic restraint stress. Pathological changes in rat penis tissue were studied by hematoxylin and eosin staining. The serum dopamine level was quantified by an enzyme-linked immunosorbent assay. The expression of related proteins and mRNA was detected by western blotting and real-time quantitative reverse transcription-polymerase chain reaction. Results Hematoxylin and eosin staining showed pathological damage in the penile tissue of the model group rats. The serum dopamine level, dopamine receptor D2 (DRD2) and solute carrier family 6 member 3 (SLC6A3) protein levels in penile tissue, and DRD2 and SLC6A3 mRNA levels were lower in the model group than in the control group. Conclusion The decrease in erectile function in the depression rat model was related to dysfunction of the dopamine system and dopaminergic synapse signaling pathway.
Inflammasome assembly is required for intracellular formation of β2-microglobulin amyloid fibrils, leading to IL-1β secretion
Authors: Kaneko Naoe , Mori Wakako , Kurata Mie , Yamamoto Toshihiro , Zako Tamotsu , Masumoto Junya 
Published: May 2022

Introduction Dialysis-related amyloidosis (DRA) caused by β2-microgloblin (B2M) fibrils is a serious complication for patients with kidney failure on long-term dialysis. Deposition of B2M amyloid fibrils is thought to be due not only to serum extracellular B2M but also to infiltrating inflammatory cells, which may have an important role in B2M amyloid deposition in osteoarticular tissues in patients with DRA. Here, we asked whether B2M amyloid fibrils activate the inflammasome and contribute to formation and deposition of amyloid fibrils in cells. Methods Amyloid formation was confirmed by a thioflavin T (ThT) spectroscopic assay and scanning electron microscopy (SEM). Activation of inflammasomes was assessed by detecting interleukin (IL)-1β in culture supernatants from human embryonic kidney (HEK) 293T cells ectopically expressing inflammasome components. IL-1β secretion was measured by enzyme-linked immunosorbent assay. Expression and co-localization were analyzed by immunohistochemistry and dual immunofluorescence microscopy. Results B2M amyloid fibrils interacted directly with NLRP3/Pyrin and to activate the NLRP3/Pyrin inflammasomes, resulting in IL-1β secretion. When HEK293T cells were transfected with inflammasome components NLRP3 or Pyrin, along with ASC, pro-caspase-1, pro-IL-1β, and B2M, ThT fluorescence intensity increased. This was accompanied by IL-1β secretion, which increased in line with the amount of transfected B2M. In this case, morphological glowing of amyloid fibrils was observed by SEM. In the absence of ASC, there was no increase in ThT fluorescence intensity or IL-1β secretion, or any morphological glowing of amyloid fibrils. NLRP3 or Pyrin and B2M were co-localized in a “speck” in HEK293T cells, and co-expressed in infiltrated monocytes/macrophages in the osteoarticular synovial tissues in a patient with DRA. Conclusion Taken together, these data suggest that inflammasome assembly is required for the subsequent triggering of intracellular formation of B2M amyloid fibrils, which may contribute to osteoarticular deposition of B2M amyloid fibrils and inflammation in patients with DRA.
Economic Evaluation of an Intervention to Prevent Adolescent Dating Violence (Me & You)
Authors: Weber Ellerie , Peskin Melissa F. , Markham Christine M. , Shegog Ross , Baumler Elizabeth R. , Addy Robert C. , Temple Jeff R. , Hernandez Belinda , Cuccaro Paula , Thiel Melanie A. , Gabay Efrat K. , Tortolero Emery Susan 
Published: May 2022

Me & You: Building Healthy Relationships (Me & You) is a multilevel, technology-enhanced adolescent dating violence (DV) prevention program that aimed to reduce DV among ethnic-minority, early adolescent, urban youth. A group-randomized control trial of Me & You, conducted with 10 middle schools from a large urban school district in Southeast Texas in 2014–2015, found it to be effective in reducing DV perpetration and decreasing some forms of DV victimization. Economic evaluations of DV interventions are extremely limited, despite calls for more economic analyses to be incorporated in research. We help fill this gap by evaluating the cost-effectiveness from the payer and societal perspectives of implementing the Me & You program. Using cost data collected alongside the Me & You group-randomized trial, we computed incremental cost-effectiveness ratios. Our primary outcome was “any DV perpetrated” within 12 months of the intervention. We conducted a cost–benefit analysis beyond the intervention endpoint by using literature estimates of per-victim lifetime costs of DV. We performed sensitivity analyses to assess effects of uncertain parameters. Under the base-case scenario, the cost of the Me & You curriculum compared to the standard curriculum was $103.70 per-student from the societal perspective, and the effectiveness was 34.84 perpetrations averted, implying an incremental cost per perpetration averted of $2.98, which ranged from $0.48 to $73.24 in sensitivity analysis. Thus, we find the Me & You curriculum is cost-effective and cost-saving in most scenarios. Policymakers should carefully consider school-based DV prevention programs, and cost data should be regularly collected in adolescent prevention program evaluations.
Numerical study on the rotational and machining accuracy of an end-milling process with spindles supported by aerostatic bearings
Authors: Shimada Keita , Wakabayashi Daisuke , Shimoyakawa Yuma , Kawada Shouhei , Miyatake Masaaki , Yoshimoto Shigeka 
Published: May 2022

Aerostatic bearings are widely used for spindles in ultra-precision machining tools. These spindles consist of a pair of aerostatic thrust bearings and several aerostatic journal bearings. The rotational accuracy of aerostatic spindles depends largely on the arrangement and performance of the individual bearings, but the evaluation of the rotational accuracy is mainly carried out experimentally using a prototype machine, which poses challenges in terms of the time and cost of building a prototype. Therefore, a real need exists to evaluate the spindle characteristics by numerical calculation. In this study, we developed a method to numerically calculate the trajectory of the spindle rotator which is supported by aerostatic bearings. The method was developed to numerically investigate and determine the effects on the rotational accuracy of the spindle during end milling when the cutting force is applied to the rotating rotor. A comparison was made regarding the amount of runout of the rotating shaft when side milling was performed using a spindle with a shaft diameter of 22 mm and a small end mill with a diameter of 1 mm, concerning three different spindles with different arrangements of thrust and journal bearings. The effects of rotational speed, radial depth of cut, and the number of tool teeth on the runout of the rotating shaft were numerically verified. As a result, it was found that a spindle structure in which the thrust bearing is placed on the tool side and the journal bearing span is lengthened is desirable.
Mental health problems in refugee and immigrant primary school children in Flanders, Belgium
Authors: Kevers Ruth , Spaas Caroline , Colpin Hilde , Van Den Noortgate Wim , de Smet Sofie , Derluyn Ilse , De Haene Lucia 
Published: May 2022

Background European countries face the challenge of promoting refugee and immigrant children’s well-being within their host communities, invoking the necessity of adequate mental health assessment. This study aims to contribute to document the psychosocial well-being of primary school refugee and non-refugee immigrant children in Flanders, Belgium. Method A total of 120 children (8–12 years old) with migration backgrounds participated in the study. Through self-report, parent and teacher questionnaires we scrutinized externalizing and internalizing behavioral problems, post-traumatic stress problems, and classroom relationships. Results Thirty percent of the participants reported high levels of post-traumatic stress; around 25% reported a high or very high prevalence of internalizing and externalizing behavioral problems. Self-reported mental health problems are elevated in comparison to the general population. Refugee children did not report more difficulties than their immigrant peers. In the perception of parents and teachers, respectively 20% and 5% of children showed high or very high amounts of internalizing and externalizing behavioral difficulties. Almost 70% of the participants perceived the class climate as unsafe. Conclusions Refugee and immigrant children are at risk for mental health difficulties, and experience classroom dynamics as markedly distressful. School-based intervention might be particularly suited to support these children’s psychosocial well-being in resettlement.
Plasma proteomics reveals an improved cardio-metabolic profile in patients with type 2 diabetes post-liraglutide treatment
Authors: Ekhzaimy Aishah A , Masood Afshan , Benabdelkamel Hicham , Elhassan Tasnem , Musambil Mohthash , Alfadda Assim A 
Published: May 2022

Background Diabetes mellitus is a chronic multisystem disease with a high global prevalence, including in Saudi Arabia. The Glucagon-like Peptide (GLP-1) receptor agonist liraglutide is known to lower glucose levels, reduce weight and improve cardiovascular outcome. However, mechanisms underlying the benefits of liraglutide treatment in patients with type 2 diabetes mellitus (T2DM) remain unclear. Methods In the present study, a 2D-DIGE MALDI-TOF mass spectrometric approach combined with bioinformatics and network pathway analysis explore the plasma proteomic profile. The study involved 20 patients with T2DM with mean age of 54.4 ± 9.5 years and Hemoglobin A1c (HbA1c) between 8% and 11% (inclusive). Results A statistically significant change ( p < .006) was observed in HbA1c with no significant changes in body weight, renal function, or markers of dyslipidemia post-treatment with liraglutide. 2 D-DIGE gel analysis identified significant changes (⩾1.5-fold change, Analysis of variance (ANOVA), p ⩽ 0.05) in 72 proteins, (62 down and 10 up) in liraglutide pre-treatment compared to the post-treatment state. Proteins identified in our study were found to regulate metabolic processes including acute phase response proteins, enzymes, apolipoproteins with involvement of the inflammatory signaling pathways, NF-κB, AKT, and p38 MAPK Conclusion Liraglutide treatment decreased levels of acute phase response that to reduce the systemic chronic inflammatory state and oxidative stress, and eventually improve the cardio-metabolic profile in these patients.
Effects of Repetitive Transcranial Magnetic Stimulation on Motor Symptoms in Parkinson’s Disease: A Meta-Analysis
Authors: Li Ruoyu , He Yijing , Qin Wenting , Zhang Zhuoyu , Su Junhui , Guan Qiang , Chen Yuhui , Jin Lingjing 
Published: May 2022

Background Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique that has been closely examined as a possible treatment for Parkinson’s disease (PD). Owing to various rTMS protocols and results, the optimal mode and suitable PD symptoms have yet to be established. Objectives This study intends to systematically evaluate the efficacy of rTMS intervention and identify optimal stimulation protocol of rTMS for specific motor symptoms. Methods PubMed and web of Science databases were searched before January 2022. Eligible studies included sham-controlled and randomized clinical trials of rTMS intervention for motor dysfunction in patients with PD. Standard mean difference (SMD) was calculated with random-effects models. The effects of rTMS on motor symptoms were mainly estimated by the UPDRS-III. Results A total of 1172 articles were identified, of which 32 articles met the inclusion criteria for meta-analysis. The pooled evidence suggested that rTMS relieves motor symptoms of patients with PD (SMD 0.64, 95%CI [0.47, 0.80]). High frequency stimulation on M1 is the most effective mode of intervention (SMD 0.79, 95%CI [0.52, 1.07]). HF rTMS has significant therapeutic effects on limbs motor function (SMD 1.93, 95%CI [0.73, 3.12] for upper limb function and SMD 0.88, 95%CI [0.43, 1.33] for lower limb function), akinesia (SMD 1.17, 95%CI [0.43, 1.92), rigidity (SMD 1.02, 95%CI [0.12, 1.92]) and tremor(SMD 0.91, 95%CI [0.15, 1.67]). Conclusion rTMS therapy is an effective treatment for motor symptoms of PD and the individualized stimulation protocols for different symptoms would further improve its clinical efficacy.
Achieving High Strength-plasticity of Nanoscale Lamellar Grain Extracted from Gradient Lamellar Nickel
Authors: Wang Zimeng , Jia Yunfei , Zhang Yong , Tang Pei , Zhang Xiancheng , Tu Shantung 
Published: May 2022

AbstractTraditional metallic materials usually face a dilemma between high strength and poor strain hardening capacity. However, heterogeneous structured metallic materials have been found to obviously overcome the trade-off. Herein, gradient lamellar structure was fabricated through ultrasound-aided deep rolling technique in pure Ni with high stacking fault energy after heat treatment. The gradient lamellar Ni was successively divided into the four regions. In-situ micropillar compression tests were conducted in different regions to reveal the corresponding microscopic mechanical properties. Microscopic characterization techniques were performed to explore underlying deformation mechanisms and the effects of microstructural parameters on deformation behaviors. This work demonstrates that the micropillar with near nanoscale lamellar thickness possesses excellent strength and plasticity. On one hand, the reason for high strength of near nanoscale micropillar is that the strength of micropillar increases with the decrease of lamellar thickness according to the Hall-Petch effect. On the other hand, numerous lamellar grain boundaries perpendicular to the loading direction is found to hinder the motion of slip bands, resulting in great strain hardening capacity in the near nanoscale lamellar micropillar.
Pseudo-tumor renal tuberculosis: a case report
Authors: El Gdaouni Abdelaziz , Ziouziou Imad 
Published: May 2022

Abstract
Background
Renal lesion is a very frequent location of tuberculosis disease, the diagnosis of which is often difficult and delayed due to its atypical clinical presentations, especially in its pseudo-tumoral form.

Case presentation
Patient of 54 year old was referred after a kidney mass was found on an abdominal ultrasound. In addition, the patient reported the notion of minimal intermittent low back pain with weight loss. On computed tomography, it was a nodular lesion of the superior pole of the right kidney, and it has a heterogeneous density and a suspicious appearance. A total nephrectomy was performed by subcostal incision. Pathological examination of the specimen revealed the presence of diffuse gigantocellular granulomas with caseous necrosis suggestive of renal tuberculosis.

Conclusion
Despite the rarity of this form, renal tuberculosis should always be thought in order to avoid radical treatment.
Joint interactions of carbon and nitrogen metabolism dominated by bicarbonate and nitrogen in Orychophragmus violaceus and Brassica napus under simulated karst habitats
Authors: Xia Antong , Wu Yanyou 
Published: May 2022

AbstractKarst habitats are uniquely characterized by high bicarbonate, high nitrate, and low ammonium, which are in-conducive to their growth and biodiversity. The occurrence of inorganic carbon and nitrogen in karst soil profoundly affects the carbon/nitrogen metabolism and adaptability of plants. However, there has been no final conclusion to the joint interactions of carbon and nitrogen metabolism in plants under karst habitats. In this study, we selected a karst-adaptable plant Orychophragmus violaceus (Ov), and a non-karst-adaptable plant Brassica napus (Bn) as experimental plants, and compared their joint effects of carbon and nitrogen metabolism under simulated karst habitats. It was found that the two species had different joint effects of carbon and nitrogen metabolisms. Bicarbonate and nitrate joint promoted photosynthetic activity and glucose metabolism, facilitating the carbon/nitrogen metabolism and growth of Ov, but their impacts on the carbon and nitrogen metabolism were insignificant in Bn. Bicarbonate and ammonium joint inhibited the photosynthesis and nitrogen metabolism, but promoted water use efficiency in Ov, leading to its enhance of growth reduction, ammonium toxicity alleviation, and drought resistance, while they inhibited the water use efficiency of Bn. In general, bicarbonate and nitrate/ammonium more significantly joint affected the carbon and nitrogen metabolism in Ov than Bn, which is vital for Ov to adapt to karst habitats.
Focal points of preanesthesia evaluations for electroconvulsive therapy in patients with depression: a retrospective analysis of clinical characteristics in nonremission
Authors: Zou Lei , Li Xiao , Chen Qibin , Lv Feng , Min Su 
Published: May 2022

Abstract
Background
This study explored the patient clinical characteristics that may affect electroconvulsive therapy (ECT) efficacy to enable improved focus during evaluations and preparation for ECT.

Methods
Patients were enrolled for ECT at the Department of Psychiatry and Anesthesiology of the First Affiliated Hospital of Chongqing Medical University from December 2017 to January 2019. The primary outcome in our study was defined as the development of nonremission. A multivariate logistic analysis was performed to identify the risk factors for nonremission.

Results
In total, 874 depressed patients were included in the study. After the ECT treatment, 255 cases (29.2%) exhibited nonremission. A multivariate logistic regression analysis of the variables was performed, and the results showed that atherosclerosis (OR 8.072, 95% CI 2.442 to 16.675; P = 0.001), COPD (OR 2.919, 95% CI 1.240 to 6.871; P = 0.014), diabetes (OR 2.202, 95% CI 1.115 to 4.348; P = 0.023) and smoking (OR 1.519, 95% CI 1.015 to 2.273; P = 0.042) were independent risk factors for nonremission.

Conclusion
In the retrospective analysis, we found that atherosclerosis, diabetes, COPD and smoking may be high-risk factors for nonremission.