bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observation on the efficacy of sublingual immunotherapy with dust mite allergen for perennial allergic rhinitis and the mechanism of action on ILCs with ILC1s and ILC2s and ILC3s
Authors: Tang Guangjun , Lan Youxing , Do Bo , Lu Jiafeng , Yang Kai , Chai Long , Chen Fangming , Tian Li 
Published: December 2022

Background:
Allergic rhinitis (AR) is considered to be 1 of the most difficult diseases to treat globally. It has a serious impact on the quality of life and social economy of patients and has become an important global health problem. Several drugs have been recommended to treat AR, but their effectiveness and mechanism of action in these patients remain unclear. The purpose of this study will be to compare the efficacy and mechanism of action of 2 drugs for the treatment of AR (moderate to severe): a Dermatophagoides Farinae Drops Sublingual Immunotherapy and a Momethasone Furoate nasal spray as an adjunct to the treatment of subjects with AR.

Methods:
A randomized, prospective, double-blind (patient and evaluator) clinical trial. The participants (n = 60) will be randomly distributed into 2 groups. The experimental group will receive a sublingual Immunotherapy for 3 months. The control group will receive the mometasone furoate nasal spray for 3 months. Before treatment, 1 month and 3 months after treatment, total nasal symptom score scale, Visual analogue Scale and Quality of Life questionnaire of rhinoconjunctivitis will be measured and Changes of the serums of IgE, interferon-γ, IL-4, IL-17, tumor necrosis factor-α, IL-5, IL-9, IL-13, IL-25, IL-33, vascular endothelial growth factor, TSLP and IL-22 in both groups. The measurements will be performed by the same researcher who was unaware of the participants’ subgroup.

Discussion:
We believe that the treatment of perennial AR with sublingual Immunotherapy and nasal hormones will be more effective in these patients. Furthermore, the sublingual Immunotherapy mainly acts mostly on the cellular immunity, while nasal hormones mainly act on local inflammatory responses. We expect to clarify which treatments are more effective and how they work in improving perennial AR.
Association Between Physical Activity Levels in Different Domains and Cardiac Autonomic Modulation in Breast Cancer Survivors
Authors: Palma Mariana R. , Vanderlei Luiz Carlos M. , Tosello Giuliano , Fregonesi Cristina , Ribeiro Fernanda E. , Cucato Gabriel G. , Ritti-Dias Raphael M. , Tebar William R. , Christofaro Diego Giulliano Destro 
Published: December 2022

Background
Breast cancer survivors frequently present cardiac autonomic dysfunction. Physical activity (PA) has been associated with better cardiac autonomic modulation (CAM) in breast cancer survivors.

Objective
This study aimed to analyze the association between CAM and PA levels performed in different domains (work and occupation, sport and exercise, and leisure time and commuting) in breast cancer survivors.

Methods
This is a cross-sectional study with 99 breast cancer survivors (age, 55.3 ± 10.4 years). Cardiac autonomic modulation was assessed by heart rate variability, and PA levels at work and occupation, sport and exercise, and leisure time and commuting were assessed using the Baecke PA questionnaire. The sum of these 3 domains provided the total PA. The Mann-Whitney test was used to compare CAM between active and inactive women in different domains of PA.

Results
Cardiac autonomic modulation was similar between active and inactive women in the different domains (P > .05). However, when considering the total PA, active breast cancer survivors presented higher SDNN (average standard deviation of all normal RR intervals) (20.0 ± 13.4 vs 28.8 ± 14.0; P = .008) and SD2 (standard deviation of the long-term intervals between consecutive heartbeats) indices (29.2 ± 17.3 vs 38.7 ± 19.9; P = .005) compared with their inactive counterparts.

Conclusion
Breast cancer survivors with higher total PA presented better CAM compared with their less active peers.

Implications for practice
The results of this study are promising and show the importance of increasing PA levels in different domains for the maintenance of cardiovascular health among breast cancer survivors.
Aging Affects the Efficacy of Platelet-Rich Plasma Treatment for Osteoarthritis
Authors: Chowdhary Kuntal , Sahu Amrita , Iijima Hirotaka , Shinde Sunita , Borg-Stein Joanne , Ambrosio Fabrisia 
Published: December 2022

ABSTRACT

Objective
Despite the increased use of platelet-rich plasma (PRP) in the treatment of osteoarthritis (OA), whether and how age of the PRP donor affects therapeutic efficacy is unclear.

Design

In vitro, male osteoarthritic human chondrocytes were treated with PRP from young (18-35 years) or old (≥65 years) donors, and chondrogenic profile was evaluated using immunofluorescent staining for two markers of chondrogenicity, type II collagen and SOX-9. In vivo, we used a within-subjects design to compare Osteoarthritis Research Society International (OARSI) scores in aged mouse knee joints injected with PRP from young or old individuals.

Results

In vitro experiments revealed that PRP from young donors induced a more youthful chondrocyte phenotype, as evidenced by increased type II collagen (p = 0.033) and SOX-9 expression (p = 0.022). This benefit, however, was significantly blunted when cells were cultured with PRP from aged donors. Accordingly, in vivo studies revealed that animals treated with PRP from young donors displayed a significantly improved cartilage integrity when compared to knees injected with PRP from aged donors (p = 0.019).

Conclusion
Injection of PRP from a young individual induced a regenerative effect in aged cells and mice, whereas PRP from aged individuals showed no improvement chondrocyte health and cartilage integrity.
Causal Inference of CNS-regulated Hormones in COVID-19: A Bidirectional Two-sample Mendelian Randomization Study
Authors: Sun Yuxuan , Ding Ziyi , Guo Yawei , Yuan Jinqiu , Zhu Chengming , Pan Yihang , Sun Rui 
Published: December 2022

AbstractObjectivesWe assessed the causal association of three COVID-19 phenotypes with insulin-like growth factor 1 (IGF-1), estrogen, testosterone, dehydroepiandrosterone (DHEA), thyroid-stimulating hormone (TSH), thyrotropin-releasing hormone (TRH),luteinizing hormone (LH), and follicle-stimulating hormone (FSH).MethodsWe used a bidirectional two-sample univariate and multivariable Mendelian randomization (MR) analysis to evaluate the direction, specificity, and causality of the association between CNS-regulated hormones and COVID-19 phenotypes. Genetic instruments for CNS-regulated hormones were selected from the largest publicly available genome-wide association studies in the European population. Summary-level data on COVID-19 severity, hospitalization, and susceptibility were obtained from the COVID-19 host genetic initiative.ResultsDHEA was associated with increased risks of very severe respiratory syndrome (OR=4.21, 95% CI: 1.41–12.59), consistent with the results in multivariate MR (OR=3.72, 95% CI: 1.20–11.51), and hospitalization (OR = 2.31, 95% CI: 1.13–4.72) in univariate MR. LH was associated with very severe respiratory syndrome (OR=0.83; 95% CI: 0.71–0.96) in univariate MR. Estrogen was negatively associated with very severe respiratory syndrome (OR=0.09, 95% CI: 0.02–0.51), hospitalization (OR=0.25, 95% CI: 0.08–0.78), and susceptibility (OR=0.50, 95% CI: 0.28–0.89) in multivariate MR.ConclusionsWe found strong evidence for the causal relationship of DHEA, LH, and estrogen with COVID-19 phenotypes.
New enhancer-promoter interactions are gained during tissue differentiation and reflect changes in E/P activity
Authors: Pollex Tim , Rabinowitz Adam , Gambetta Maria Cristina , Marco-Ferreres Raquel , Viales Rebecca R. , Jankowski Aleksander , Schaub Christoph , Furlong Eileen E.M. 
Published: December 2022

ABSTRACTTo regulate gene expression, enhancers must come into proximity with their target gene. At some loci the timing of enhancer-promoter proximity is uncoupled from gene activation, while at others it is tightly linked. Here, we assessed this more globally for 600 characterized enhancers or promoters (E/P) with tissue-specific activity inDrosophilaembryos, by performing Capture-C and insulator ChIP in FACS-purified myogenic or neurogenic cells at different stages of embryogenesis. This high-resolution view enabled direct comparison between E/P interactions and activity across 5 developmental conditions. This revealed largely invariant E/P contacts between the blastoderm and cell fate specification stages, despite changes in activity. However, E/P interactions diverge during terminal tissue differentiation when many tissue-specific interactions are gained on top of a pre-existing topology. Changes in E/P proximity reflect changes in enhancer activity and gene activation, and are generally not accompanied by changes in insulator binding. Using transgenes and deletions, we show that many tissue-specific interactions represent functional E-P pairs. Our results reveal a shift in E-P landscapes as embryogenesis proceeds, from largely pre-formed topologies at early stages to more distal tissue-specific loops during differentiation, when E/P proximity appears coupled to activation.
Market channel participation amongst smallholder rice farmers in the northern region of Ghana
Authors: Ma-Azu Abdul-Jalil , Abdul-Rahaman Awal , Zakaria Abraham , Lamptey Clement Yaw 
Published: December 2022

PurposeThis study examines the drivers of marketing channel participation amongst smallholder rice farmers in the northern region of Ghana.Design/methodology/approachUsing a sample of 397 smallholder rice farmers drawn from a multistage sampling procedure, the study employed multivariate probit (MVP) model in the empirical estimations. In this context, the model assumes that a rice farmer should at least participate in one market channel.FindingsThe study reveals that the wholesaler market channel is the most commonly used channel among farmers, followed by the aggregator channel. However, the processor market channel is the least patronized one in the study area. The results also show statistically significant correlation coefficients in four out of the six possible combinations, implying that market channel participation among smallholder farmers is not mutually exclusive. Rice market channel participation is positively and significantly influenced by age, gender, household headship, access to credit, extension service, irrigation, improved seed and access to price information.Research limitations/implicationsThis study is limited in extending the analysis to include the impact of market channels on some outcome measures. This is due to data limitation.Originality/valueThe findings of this study add to the growing literature on smallholder market channel participation in Ghana.
Prospects for Agroecology in Europe
Authors: Matthews Alan 
Published: December 2022

SummaryAgroecology is not a new concept. Its rising prominence, however, is linked to greater societal awareness of environmental pressures associated with agricultural practices, a decline in the number of farmers, the growing market power of major corporate businesses, and links between ill‐health and patterns of food consumption. In this context, agroecology is proposed as an alternative and sustainable model for agricultural production and for organising food systems. However, the uptake of agroecological practices in Europe is low. Fewer than 3 per cent of all farms have been defined as agroecological by achieving a pre‐determined threshold on all five of key management principles. Economic viability, specifically the return to labour, will be a key factor in determining the attractiveness of agroecological practices to farmers and ultimately the farming system chosen. If current market conditions and economic incentives prove to be insufficient to promote the uptake of agroecological practices, then the associated non‐market or social benefits may be key in generating appropriate rewards to farmers adopting these systems.
A Review of the research methods and progress of biocompatibility evaluation of root canal sealers
Authors: Yang Xiliang , Zheng Tianxia , Yang Nuoya , Yin Zihan , Wang Wuliang , Bai Yuhong 
Published: December 2022

AbstractThe function of root canal sealer was to achieve an appropriate three‐dimensional filling effect by filling the root canal and some irregular lumen, thereby inhibiting the residual bacteria. There were many types of sealers, but research to find the most suitable ones was still ongoing. In recent years, researchers had continuously improved the performance of sealers by developing new sealers or adding active ingredients to the sealers. However, most sealers exhibit varying degrees of cytotoxicity and tissue responses, which affect clinical therapy efficacy. This review describes different technical approaches, and recent research progress in the biocompatibility evaluation of root canal sealers and provides brief insights into this field by summarising the performance studies of different root canal sealers.
Enigma moth parasitoid: a new Australian cyclostome genus and species, Ovaustra aurantia Tetley, Glatz & Fagan Jeffries, gen. et sp. nov. (Hymenoptera: Braconidae) from Kangaroo Island
Authors: Glatz Richard V. , Fagan‐Jeffries Erinn P. , Tetley Shannon P. , Austin Andrew D. 
Published: December 2022

AbstractOvaustra aurantia Tetley, Glatz & Fagan‐Jeffries, gen. et sp. nov. (Mesostoinae) is described from Kangaroo Island. South Australia, Australia, and is a solitary, koinobiont, egg‐larval parasitoid of the enigma moth, Aenigmatinea glatzella Kristensen & Edwards, 2015, in the monotypic family Aenigmatineidae Kristensen & Edwards, 2015 (Lepidoptera). Female parasitoids oviposit into the eggs of A. glatzella soon after female moths place them beneath minute adpressed leaves at the growing foliar tips of the larval host plant Callitris gracilis R.T. Baker (Cupressaceae). Adult parasitoids emerge from A. glatzella larval chambers located directly beneath the bark of small branches, some way from the growing tip. Adults can be seen on or near foliage of C. gracillis primarily during October and coinciding with the presence of adult host moths. Morphological and preliminary molecular evidence place Ovaustra Glatz, Fagan‐Jeffries & Tetley, gen. nov. within Mesostoinae s.l. and indicate that its closest relatives are likely to reside within a group of genera from Australia and New Zealand whose hosts and biology are not well defined but are apparently quite broad, including lepidopteran, coleopteran and dipteran larvae, as well as primary plant gall induction.
The Australian and New Zealand Society for Sarcopenia and Frailty Research (ANZSSFR) sarcopenia diagnosis and management task force: Findings from the consumer expert Delphi process
Authors: Zanker Jesse , Sim Marc , Anderson Kate , Balogun Saliu , Brennan‐Olsen Sharon L. , Dent Elsa , Duque Gustavo , Girgis Christian M. , Grossmann Mathis , Hayes Alan , Henwood Tim , Hirani Vasant , Inderjeeth Charles , Iuliano Sandra , Keogh Justin , Lewis Joshua R. , Lynch Gordon S. , Pasco Julie A. , Phu Steven , Reijnierse Esmee M. , Russell Nicholas , Vlietstra Lara , Visvanathan Renuka , Walker Troy , Waters Debra L. , Yu Solomon , Maier Andrea B. , Daly Robin M. , Scott David 
Published: December 2022

AbstractObjectivesTo develop guidelines, informed by health‐care consumer values and preferences, for sarcopenia prevention, assessment and management for use by clinicians and researchers in Australia and New Zealand.MethodsA three‐phase Consumer Expert Delphi process was undertaken between July 2020 and August 2021. Consumer experts included adults with lived experience of sarcopenia or health‐care utilisation. Phase 1 involved a structured meeting of the Australian and New Zealand Society for Sarcopenia and Frailty Research (ANZSSFR) Sarcopenia Diagnosis and Management Task Force and consumer representatives from which the Phase 2 survey was developed. In Phase 2, consumers from Australia and New Zealand were surveyed online with opinions sought on sarcopenia outcome priorities, consultation preferences and interventions. Findings were confirmed and disseminated in Phase 3. Descriptive statistical analyses were performed.ResultsTwenty‐four consumers (mean ± standard deviation age 67.5 ± 12.8 years, 18 women) participated in Phase 2. Ten (42%) identified as being interested in sarcopenia, 7 (29%) were health‐care consumers and 6 (25%) self‐reported having/believing they have sarcopenia. Consumers identified physical performance, living circumstances, morale, quality of life and social connectedness as the most important outcomes related to sarcopenia. Consumers either had no preference (46%) or preferred their doctor (40%) to diagnose sarcopenia and preferred to undergo assessments at least yearly (54%). For prevention and treatment, 46% of consumers preferred resistance exercise, 2–3 times per week (54%).ConclusionsConsumer preferences reported in this study can inform the implementation of sarcopenia guidelines into clinical practice at local, state and national levels across Australia and New Zealand.
Image‐guided thermal ablation for patients with epidermal growth factor receptor‐mutant nonsmall cell lung cancer
Authors: Huang Yahan , Kong Yongmei , Wei Zhigang , Ye Xin 
Published: December 2022

AbstractNonsmall cell lung cancer (NSCLC) is treated by various therapies such as surgical intervention, radiotherapy, chemotherapy, molecular targeted therapy, and immunotherapy. Currently, molecular targeted therapy, including epidermal growth factor receptor (EGFR) inhibitors and Anaplastic Lymphoma Kinase (ALK) and Kirsten Rat Sarcoma viral Oncogene (KRAS) inhibitors, has received much attention and improved the prognosis of NSCLC. Nevertheless, the terminal point of molecular targeted drugs is resistance. Drug resistance has been classified into oligoprogression and extensive progression based on the tumor lesion progression after drug resistance. There is extensive research demonstrating that local therapy (surgical resection, radiotherapy, and thermal ablation) can prolong the survival of patients with drug resistance. This review is intended to determine the efficacy of image‐guided thermal ablation in patients with NSCLC with EGFR mutation.
Letter: PCSK9 inhibitor for liver transplant patients during the post‐statin era?
Authors: Wang Jiamei , Wu Jia , He Zhiqing , Xin Haiguang 
Published: December 2022

LINKED CONTENTThis article is linked to Becchetti et al papers. To view these articles,
visit https://doi.org/10.1111/apt.17192 and https://doi.org/10.1111/apt.17295
Letter: Elderly AS‐AIH patients need more attention—Authors' reply
Authors: Téllez Luis , Sánchez‐Rodríguez Eugenia , Rodríguez de Santiago Enrique , Albillos Agustín 
Published: December 2022

LINKED CONTENTThis article is linked to Téllez et al papers. To view these articles, visit
https://doi.org/10.1111/apt.16926 and https://doi.org/10.1111/apt.17240
Letter: PCSK9 inhibitor for liver transplant patients during the post‐statin era? Authors' reply
Authors: Becchetti Chiara , Dirchwolf Melisa , Berzigotti Annalisa , Bosch Jaume 
Published: December 2022

LINKED CONTENTThis article is linked to Becchetti et al papers. To view these articles,
visit https://doi.org/10.1111/apt.17192 and https://doi.org/10.1111/apt.17258
Editorial: the acid test—can bile acids predict recurrence of Clostridioides difficile infection? Authors' reply
Authors: Mullish Benjamin H. , Martinez‐Gili Laura , Allegretti Jessica R. 
Published: December 2022

LINKED CONTENTThis article is linked to Mullish et al papers. To view these articles, visit https://doi.org/10.1111/apt.17247 and https://doi.org/10.1111/apt.17266
Editorial: cannabis use disorders at the emergency department, a sign of a growing cannabinoid emergency—authors' reply
Authors: Andrews Christopher N. , Sharkey Keith A. 
Published: December 2022

LINKED CONTENTThis article is linked to Andrews et al papers. To view these articles, visit https://doi.org/10.1111/apt.17265 and https://doi.org/10.1111/apt.17300
Editorial: is microwave ablation an alternative to liver resection for hepatocellular carcinoma?
Authors: He Wei , Li Binkui , Yuan Yunfei 
Published: December 2022

LINKED CONTENTThis article is linked to Tong et al papers. To view these articles, visit https://doi.org/10.1111/apt.17263 and https://doi.org/10.1111/apt.17320
Editorial: is microwave ablation an alternative to liver resection for hepatocellular carcinoma? Authorsʼ reply
Authors: Chang De‐Hua , Xiao Yu‐Dong , Yao Tong 
Published: December 2022

LINKED CONTENTThis article is linked to Tong et al papers. To view these articles, visit https://doi.org/10.1111/apt.17263 and https://doi.org/10.1111/apt.17319
The oldest Gondwanan fossil of Leiinae (Diptera, Mycetophilidae): Phylogenetic and evolutionary implications
Authors: Amorim Dalton de Souza , Oliveira Sarah Siqueira , do Carmo Daniel Dias Dornelas , Ribeiro Guilherme Cunha 
Published: December 2022

AbstractA fossil Mycetophilidae from the Aptian Crato Formation—Cretomanota gondwanicagen. nov., sp. nov.—is described, which is the first mycetophilid from the Crato Formation and corresponds to the oldest known fossil leiine and only the second Gondwanan fossil mycetophilid described so far.Cretomanota gondwanicaand both species ofAlavamanotaBlagoderov and Arillo were added as terminals to the data matrix of a general phylogenetic analysis of the Mycetophilidae, and both fit into the Leiinae.Alavamanotais monophyletic, sister to the clade composed byCretomanotaand the extant genusManotaWilliston. The biology of the extant members of this fungivorous family corroborates the reconstruction of the Crato palaeoenvironment as including woodlands with humid habitats and microhabitats. The presence of a Cretaceous member of the tribe Manotini at low latitudes in South America reinforces the hypothesis that the clade with all manotines exceptLeiellaEdwards corresponds to a Lower Cretaceous offshoot from a group in southern Gondwana expanding its distribution to more northern areas into the Gondwana and into Laurasia.
Caring for transgender populations: A primer for the dermatopathologist
Authors: Sood Aditya , Stoff Benjamin K. , Yeung Howa 
Published: December 2022

AbstractWith increasing access to electronic health records, patients may encounter dermatopathology reports more readily. Dermatopathologists should consider their impact and interactions with transgender patients, who may face specific health and healthcare inequities. Rendering accurate diagnosis for skin diseases requires accurate information about patient's sex assigned at birth and gender identity. Understanding how sex and gender identity data flow between electronic health records, laboratory information systems, insurance billing systems, and patients will be important to avoid patient misgendering, to render accurate diagnoses, to maintain consistency in dermatopathology reports, and to avoid insurance billing denials. Dermatopathologists have important roles to build patient trust in the healthcare system and to help dermatologists diagnose, treat, and characterize skin diseases in transgender populations.