bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the Complexity of Glucose Time Series on All-Cause Mortality in Patients With Type 2 Diabetes
Authors: Cai Jinghao , Yang Qing , Lu Jingyi , Shen Yun , Wang Chunfang , Chen Lei , Zhang Lei , Lu Wei , Zhu Wei , Xia Tian , Zhou Jian 
Published: December 2022

AbstractContextPrevious studies suggest that the complexity of glucose time series may serve as a novel marker of glucose homeostasis.ObjectiveWe aimed to investigate the relationship between the complexity of glucose time series and all-cause mortality in patients with type 2 diabetes.MethodsProspective data of 6000 adult inpatients with type 2 diabetes from a single center were analyzed. The complexity of glucose time series index (CGI) based on continuous glucose monitoring (CGM) was measured at baseline with refined composite multiscale entropy. Participants were stratified by CGI tertiles of: &lt; 2.15, 2.15 to 2.99, and ≥ 3.00. Cox proportional hazards regression models were used to assess the relationship between CGI and all-cause mortality.ResultsDuring a median follow-up of 9.4 years, 1217 deaths were identified. A significant interaction between glycated hemoglobin A1c (HbA1c) and CGI in relation to all-cause mortality was noted (P for interaction = 0.016). The multivariable-adjusted hazard ratios for all-cause mortality at different CGI levels (≥ 3.00 [reference group], 2.15-2.99, and &lt; 2.15) were 1.00, 0.76 (95% CI, 0.52-1.12), and 1.47 (95% CI, 1.03-2.09) in patients with HbA1c &lt; 7.0%, while the association was nonsignificant in those with HbA1c ≥ 7.0%. The restricted cubic spline regression revealed a nonlinear (P for nonlinearity = 0.041) relationship between CGI and all-cause mortality in subjects with HbA1c &lt; 7.0% only.ConclusionLower CGI is associated with an increased risk of all-cause mortality among patients with type 2 diabetes achieving the HbA1c target. CGI may be a new indicator for the identification of residual risk of death in well-controlled type 2 diabetes.
Association of Longitudinal Activity Measures and Diabetes Risk: An Analysis From the National Institutes of Health All of Us Research Program
Authors: Perry Andrew S , Annis Jeffrey S , Master Hiral , Nayor Matthew , Hughes Andrew , Kouame Aymone , Natarajan Karthik , Marginean Kayla , Murthy Venkatesh , Roden Dan M , Harris Paul A , Shah Ravi , Brittain Evan L 
Published: December 2022

Abstract

Context
Prior studies of the relationship between physical activity and incident type 2 diabetes mellitus (T2DM) relied primarily on questionnaires at a single time point.

Objective
We sought to investigate the relationship between physical activity and incident T2DM with an innovative approach using data from commercial wearable devices linked to electronic health records in a real-world population.

Methods
Using All of Us participants’ accelerometer data from their personal Fitbit devices, we used a time-varying Cox proportional hazards models with repeated measures of physical activity for the outcome of incident T2DM. We evaluated for effect modification with age, sex, body mass index (BMI), and sedentary time using multiplicative interaction terms.

Results
From 5677 participants in the All of Us Research Program (median age 51 years; 74% female; 89% White), there were 97 (2%) cases of incident T2DM over a median follow-up period of 3.8 years between 2010 to 2021. In models adjusted for age, sex, and race, the hazard of incident diabetes was reduced by 44% (95% CI, 15%-63%; P = 0.01) when comparing those with an average daily step count of 10 700 to those with 6000. Similar benefits were seen comparing groups based on average duration of various intensities of activity (eg, lightly active, fairly active, very active). There was no evidence for effect modification by age, sex, BMI, or sedentary time.

Conclusion
Greater time in any type of physical activity intensity was associated with lower risk of T2DM irrespective of age, sex, BMI, or sedentary time.
Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans
Authors: Sommer Christine , Vangberg Kjersti G , Moen Gunn-Helen , Evans David M , Lee-Ødegård Sindre , Blom-Høgestøl Ingvild K , Sletner Line , Jenum Anne K , Drevon Christian A , Gulseth Hanne L , Birkeland Kåre I 
Published: December 2022

AbstractContextSerum soluble leptin receptor (sOb-R) may protect against future type 2 diabetes or serve as a marker for protective features, but how sOb-R is regulated is largely unknown.ObjectiveThis work aimed to test how serum sOb-R is influenced by glucose, insulin, body fat, body mass index (BMI), food intake, and physical activity.MethodsWe performed an epidemiological triangulation combining cross-sectional, interventional, and Mendelian randomization study designs. In 5 independent clinical studies (n = 24-823), sOb-R was quantified in serum or plasma by commercial enzyme-linked immunosorbent assay kits using monoclonal antibodies. We performed mixed-model regression and 2-sample Mendelian randomization.ResultsIn pooled, cross-sectional data, leveling by study, sOb-R was associated inversely with BMI (β [95% CI] −0.19 [−0.21 to −0.17]), body fat (−0.12 [−0.14 to −0.10), and fasting C-peptide (−2.04 [−2.46 to −1.62]). sOb-R decreased in response to acute hyperinsulinemia during euglycemic glucose clamp in 2 independent clinical studies (−0.5 [−0.7 to −0.4] and −0.5 [−0.6 to −0.3]), and immediately increased in response to intensive exercise (0.18 [0.04 to 0.31]) and food intake (0.20 [0.06 to 0.34]). In 2-sample Mendelian randomization, higher fasting insulin and higher BMI were causally linked to lower sOb-R levels (inverse variance weighted, −1.72 [−2.86 to −0.58], and −0.20 [−0.36 to −0.04], respectively). The relationship between hyperglycemia and sOb-R was inconsistent in cross-sectional studies and nonsignificant in intervention studies, and 2-sample Mendelian randomization suggested no causal effect of fasting glucose on sOb-R.ConclusionBMI and insulin both causally decreased serum sOb-R levels. Conversely, intensive exercise and food intake acutely increased sOb-R. Our results suggest that sOb-R is involved in short-term regulation of leptin signaling, either directly or indirectly, and that hyperinsulinemia may reduce leptin signaling.
Selective refinement of glutamate and GABA synapses on dorsal raphe 5-HT neurons during postnatal life
Authors: Argañaraz Carla V. , Adjimann Tamara S. , Perissinotti Paula P. , Soiza-Reilly Mariano 
Published: December 2022

ABSTRACT
Serotonin (5-hydroxytryptamine, 5-HT) neurons are implicated in the etiology and therapeutics of anxiety and depression. Critical periods of vulnerability during brain development enable maladaptive mechanisms to produce detrimental consequences on adult mood and emotional responses. 5-HT plays a crucial role in these mechanisms; however, little is known about how synaptic inputs and modulatory systems that shape the activity of early 5-HT networks mature during postnatal development. We investigated in mice the postnatal trajectory of glutamate and GABA synaptic inputs to dorsal raphe nucleus (DRN) 5-HT neurons, the main source of forebrain 5-HT. High-resolution quantitative analyses with array tomography and ex vivo electrophysiology indicate that cortical glutamate and subcortical GABA synapses undergo a profound refinement process after the third postnatal week, whereas subcortical glutamate inputs do not. This refinement of DRN inputs is not accompanied by changes in 5-HT1A receptor-mediated inhibition over 5-HT neurons. Our study reveals a precise developmental pattern of synaptic refinement of DRN excitatory and inhibitory afferents, when 5-HT-related inhibitory mechanisms are in place. These findings contribute to the understanding of neurodevelopmental vulnerability to psychiatric disorders.
This article has an associated ‘The people behind the papers’ interview.
FLIPPED CLASS METHOD IN FOREIGN LANGUAGE CLASSES AT UNIVERSITY (OPERATION ALGORITHM)
Authors: Lubozheva Lionella N. 
Published: December 2022

Background now, amid growing competition in the labor market, new approaches to foreign-language education are needed. The urgent task of implementing educational programs of the specialty is to train specialists capable of professional activities. According to the standard in the specialty 38.05.01 Economic Security, one of the results of training is “the ability to carry out business communication in oral and written forms in a foreign language,” that is, foreign-language communication is a key component for the successful professional activities of a specialist. There is a contradiction between the requirement of the standard of higher education and the current level of development of competence among students, which makes this work relevant. The teachers’ task is to organize the educational process to make the students’ activities successful and knowledge be in demand. To solve the problem, you can use the Flipped Class method, so there is a need to develop an algorithm for the work of participants in the educational process using this method.
The main purpose of the work is the development of an algorithm for the actions of a teacher and a student in classes of any foreign language at a university applying the “Flipped Class” method.
Methods: general scientific (analysis, synthesis, deduction) and private scientific (testing, observation, questionnaire).
Results: proposed the conditions for using the studied method in classes in a foreign language and algorithms for the actions of the teacher and students at various stages of its implementation.
Conclusion: The description of algorithms for applying the “Flipped Class” method in the educational process can be used by teachers and methodologists; algorithms can be applied when teaching a foreign language to specialty students at a university.
Osilodrostat therapy in a 26-year-old patient after ineffective surgical treatment of Cushing Disease: a case report
Authors: Kamińska Magdalena , Strzoda Adam , Juda Agata , Rojek Kornelia , Strzoda Anna , Sowiński Wojciech , Polak Agnieszka 
Published: December 2022

Cushing’s Disease is caused by pituitary adenoma which produces adrenocorticotropic hormone causing hypercortisolemia. First-line treatment involves operative removal of the tumor, however, in some patients it proves ineffective. In those cases, pharmacological treatment is necessary as untreated Cushing’s Disease may be lethal. In 2020 a new steroidogenesis inhibitor – Osilodrostat - was approved by the European Medicines Agency and can be used in the treatment of patients who cannot undergo pituitary surgery or whose previous surgical treatment proved ineffective.
We present a case of a 26-year-old female patient who was diagnosed with endogenous Cushing’s Disease and underwent two consecutive operations to remove the tumor - both were ineffective. With deteriorating laboratory results and other pharmacological treatments exhausted Osilodrostat therapy was introduced.
Osilodrostat is becoming an important drug in patients with Cushing’s Disease refractory to other treatments.
Hipertekstowe inspiracje w analogowo-książkowym opowiadaniu o Toruniu
Authors: Kluczwajd Katarzyna 
Published: December 2022

Tekst jest refleksją poświęconą publikacjom Katarzyny Kluczwajd dotyczącą przenikania nowego sposobu przekazywania wiedzy i nowego języka nowych mediów do książek opartych na badaniach naukowych oraz służących edukacji. Czy i jak udaje się ten mariaż? Czy poszukiwania nietradycyjnego sposobu przekazywania wiedzy o mieście, kreatywnego w tym celu połączenia historii i literatury, z coraz szybciej zmieniającym się światem i jego percepcją, przynoszą coś nowego?
Toruń jest… jaki? Wizja miasta zależy od Ciebie (2010) – to pierwsza książka o Toruniu do czytania nieliniowego, z założeniem kreatywnej roli użytkownika – to on ma tworzyć wizję „swojego miasta”. Tom miał składać się z luźnych kart do własnego przez czytelnika „organizowania” wedle kilkunastu zarysowanych w tekście wątków tematycznych i / lub wyszczególnionych kluczy-szukaczy (topografia, chronologia, stylistyka, dziedziny).
Cztery książeczki serii Toruń SPACErkiem (2015–2017), także do czytania niesekwencyjnego, zostały pomyślane jako zespół orbit kosmosu toruńskiego dziedzictwa kulturowego – SPACE / SPACErkiem. Intertekstualność obecna jest w formie gier słownych i typograficznych zabaw. Wiedza stanowi pretekst do swego rodzaju zabawy, czyli serii tej bliżej już do przesłania nowych mediów, które ludyczność stawiają przed nauką, niż do literatury popularno-naukowej.
The implementation of a static air-foam hybrid mattress in a nursing home population: a feasibility study
Authors: Raepsaet Charlotte , Beeckman Dimitri 
Published: December 2022

Background/Aims Nursing home residents are at higher risk of developing pressure ulcers as a result of comorbidities, changes in skin texture and function, incontinence, and limited mobility, such as residents who are mostly bedbound. The aim of this study was to evaluate the introduction and use of a static air-foam hybrid mattress based on the experiences of nurses and to assess the incidence of pressure ulcers in a nursing home population at risk for developing pressure ulcers over a 14-day period. Methods A multicentre clinical trial, followed by focus group interviews with nurses, was conducted between August and October 2020 to evaluate the implementation and use of a static air-foam hybrid mattress. Residents (n=29) at risk of developing pressure ulcers were placed on the mattress for 14 days. Skin and risk assessments were performed daily. At the end of the study, nurses (n=9) were invited to participate in focus group interviews to share their experiences. Results During the study period, none of the residents developed stage 2–4 pressure ulcers. Based on nurses' experiences with the mattress, five themes were identified: design and guidance, pump use, mobility and positioning, mattress appearance and clinical opinion. Results indicated that the mattress provided a clinically effective support surface in the prevention of pressure ulcers and was easy to use. Conclusions A static air-foam hybrid mattress provides a clinically effective support surface in the prevention of pressure ulcers. Nurses preferred the mattress to an alternating pressure mattress and a static air mattress overlay.
Insights into what people think: being smart with advice on smoking
Authors: Ross Louise 
Published: December 2022

Engaging people who smoke is key to supporting them to quit. Louise Ross looks at the latest insights into the thoughts and feelings of people who smoke and how nurses can use these to encourage quitting attempts General practice nurses are in a prime position to help patients who smoke to think about quitting. New insights into the thoughts, feelings and behaviour of patients who smoke can help general practice nurses tailor their approach. This can lead to better success in engaging patients in a conversation, which can in turn lay the foundations for a radical improvement in their health.
A ATENÇÃO PRIMÁRIA, O TERRITÓRIO E AS REDES DE ATENÇÃO: INTERCAMBIAMENTOS NECESSÁRIOS PARA A INTEGRAÇÃO DAS AÇÕES DO SISTEMA ÚNICO DE SAÚDE (SUS) EM MINAS GERAIS, BRASIL
Authors: Faria Rivaldo Mauro de 
Published: December 2022

A Secretaria de Estado da Saúde de Minas Gerais, com o apoio do Ministério da Saúde, vem fazendo amplos esforços para universalizar o acesso à atenção primária à saúde, tendo em vista seu papel estratégico para a constituição das redes de atenção à saúde do Sistema Único de Saúde (SUS). Por isso, passou a incentivar a adoção das Equipes Saúde da Família através do seu "Programa Estruturador Saúde em Casa". Associado a esse programa, criou o Plano Diretor da Atenção Primária Ã Saúde (PDAPS), cujo objetivo é oferecer um instrumento de planejamento e gestão territorial desses serviços, qualificando-os para cumprir seu papel de porta de entrada das redes de atenção à saúde. O objetivo deste artigo é discutir o planejamento territorial da atenção primária e das redes de atenção à saúde do SUS em Minas Gerais, Brasil. O pressuposto hipotético norteador da discussão é a interdependência existencial entre a atenção primária, as redes e o território. A metodologia utilizada é baseada num estudo teórico-descritivo, de um lado, e numa análise teórico-crítica, de outro. Portanto, tem uma dimensão de descortinamento da relação entre as redes, o território e a atenção primária, de um lado; e uma dimensão de apontamento sobre os modos como isso vem sendo planejado, de outro. Os resultados indicam avanços na construção das redes em Minas Gerais, mas há também questões teórico-metodológicas que precisam ser devidamente equacionadas, sobretudo em relação aos modos de inscrição territorial dos serviços
INFLUÊNCIA DAS CONDIÇÕES AMBIENTAIS NA CONTAMINAÇÃO FÚNGICA DE ISCAS RODENTICIDAS EMPREGADAS NO CONTROLE DE ROEDORES EM ÁREAS URBANAS
Authors: Aquino Simone , Caldas Cirlene da Cunha , Reis Fabricio Caldeiras , Jesus Paulo Ricardo de , Silva Dirceu da , Potenza Marcos Roberto 
Published: December 2022

Animais sinantrópicos ganham cada vez mais espaço em áreas urbanas e convivem com o homem devido à crescente degradação ambiental. O método mais utilizado no gerenciamento de controle das infestações de roedores no ambiente urbano é a utilização de iscas rodenticidas comerciais, sujeitas às condições climáticas do ambiente. O presente trabalho teve por objetivo analisar a contaminação fúngica ambiental de blocos rodenticidas parafinados e não parafinados, distribuídos nas diferentes estações em um ano. Â Foi observada a contaminação por diversos gêneros fúngicos do ambiente e que a frequência de fungos contaminantes variou de acordo com os diversos fatores bióticos e abióticos, encontrados nas diferentes estações do ano, entre setembro de 2010 a setembro de 2011. Porém o predomínio do fungo Penicillium spp. indica ser este fungo o responsável pela contaminação das duas formas de apresentação (com ou sem parafina) independente das condições climáticas. O correto manejo de iscas comerciais para o controle de pragas está associado às condições ambientais, necessitando de um cronograma por sazonalidade para a substituição das iscas, a fim de reduzir a degradação fúngica e manter a qualidade dos produtos comercializados, para uso no ambiente externo e consequente execução do manejo integrado de roedores, de forma eficiente.
DISTRIBUIÇÃO ESPAÇO-TEMPORAL DAS RECLAMAÇÕES SOBRE MORCEGOS EFETUADAS AO CENTRO DE CONTROLE DE ZOONOSES DE NITERÓI, RJ (2009-2013)
Authors: Moutinho Flavio Fernando Batista , Gomes Ricardo da Silva , Serra Cathia Maria Barrientos , Valente Luiza Carneiro Mareti , Borges Fabio Villas Boas , Faria Neto Francisco de 
Published: December 2022

Com a paulatina destruição dos ecossistemas naturais aumenta-se a presença de morcegos em áreas urbanas, podendo pôr em risco a saúde coletiva, especialmente com relação Ã ocorrência da raiva. Foi realizado um levantamento das reclamações da comunidade pelo Centro de Controle de Zoonoses do município de Niterói, Rio de Janeiro, Brasil, acerca de problemas relacionados com morcegos, no período de 2009 a 2013. Foram regitradas 121 reclamações, com média anual de 24,2 casos e desvio padrão de 2,3. Houve predomínio de reclamações em fevereiro (12,4%) e o mês com menor quantidade de reclamações foi março (4,1%), não tendo sido caracterizado comportamento sazonal. Houve forte concentração e persistência das reclamações nas regiões das Praias da Baía, com 43% dos casos e Litoral, com 30,6%. A região com menor percentual de reclamações foi a Leste, com 1,6%. Houve correlação moderada entre o número de reclamações e a renda e o número de reclamações e o tamanho da população por bairro. A correlação entre o número de reclamações e a temperatura e o número de reclamações e a precipitação foi desprezível. Os dados obtidos reforçam a necessidade de monitoramento das populações de morcegos e de vigilância da circulação do vírus rábico. Além disso, esforços devem ser feitos para preservar e recuperar os ambientes naturais remanescentes nas áreas urbanas de Niterói, no sentido de manter em equilíbrio a fauna existente.
DU PALUDISME - MALÁRIA
Authors: Laveran Alphonse 
Published: December 2022

On sait depuis la plus haute antiquité que les habitants des régions marécageuses sont fréquemment atteints de fièvre et de cachexie; ces accidents ont été décrits sous des noms variés qui rappellent soit le milieu de prédilection de la maladie, soit un des caractères les plus communs de ces fièvres: l'intermittence.
Les dénominations suivantes sont employées par un grand nombre d'auteurs comme étant synonymes: fièvres palustres ou paludéennes, fièvres des marais, fièvres maremmatiques, impaludisme, paludisme, fièvres telluriques, fièvres intermittentes, mal'aria (de mala aria, en Italien, mauvais air) d'oÃ¹ l'on a fait: malaria, fièvres malariques. Ague (en Anglais); Wechselfieber (en Allemand).
Le mot paludisme qui est court et d'un emploi commode me paraÃ®t devoir être adopté à l'exclusion de toutes les autres dénominations.
METODE PENYUCIAN JIWA IMAM AL-GHAZALI
Authors: Purnama Yulia , Santalia Indo 
Published: December 2022

Library research is the type of research used in this study, which is research that aims to trace references or sources in the form of articles and journals to obtain data on ethical thoughts and methods of purifying the soul of Imam Al-Ghazali. This research model is historically factual. The analysis of the method used is interpretation, this method seeks to decipher the contents of books and other sources precisely. The second method is induction and deduction, by analyzing the entire section one by one of those references found in conjunction with the other or called induction. Data collection and analysis techniques are carried out by referring to the methods used. After conducting the analysis, a comparison was then made in terms of similarities from various sources so as to produce conclusions about the ethical thinking of Imam Al-Ghazali being religious and sufistic and the method of purifying the soul offered by Imam Al-Ghazali in the form of mujahadah, riyadhah, get along with good people and environments, learn the stories of prophets, recognize one's own disgrace, and be able to take wisdom from those who hate us. Keywords: ethical thinking; methods of purifying the soul
TRADISI PEMBACAAN SURAT AL-SAJDAH DENGAN SUJUD TILAWAH DALAM SALAT SUBUH DI HARI JUMAT DI MASJID GEDHE KAUMAN YOGYAKARTA
Authors: Ulil Albab Ahmad 
Published: December 2022

Resepsi terhadap teks al-Qur'an dan Hadis di masyarakat mengalami perkembangan mengikuti locus dan tempus yang menyertainya. Tradisi pembacaan surat al-Sajdah dengan sujud tilawah dalam salat subuh di hari Jumat di Masjid Gedhe Kauman Yogyakarta yang terilhami dari hadis Nabi tidak sepenuhnya sama dengan tradisi yang tertulis pada teks dan tradisi yang sekarang dijalankan di Jazirah Arab. Melainkan mengalami penyesuaian dengan sosio-historis yang ada di masyarakat. Dalam penelitian ini, peneliti menggunakan teori resepsi yang memiliki titik fokus dalam bentuk resepsi fungsional untuk mengetahui penyambutan agen dan objek penerima tradisi dalam memaknai tradisi tersebut.
Kata kunci: Sujud Tilawah, al-Sajdah, Masjid Gedhe, Living Hadis.
TANGGUNGJAWAB MANUSIA TERHADAP LINGKUNGAN HIDUP
Authors: Tapingku Joni 
Published: December 2022

Alam merupakan lingkungan tempat tinggal manusia. Sebagai tempat tinggal, manusia harus bertanggung jawab menjaga dan melestarikannya. Jika manusia masa bodoh terhadap lingkungannya, maka hal itu akan berdampak tidak baik kepada manusia itu sendiri.
Dalam konteks masa kini, manusia hidup dengan teknologi yang semakin canggih. Di satu sisi, semua pekerjaan manusia dapat dimudahkan dengan alat-alat yang telah diciptakan. Namun di sisi lain, dengan kemudahan seperti itu ternyata membawa dampak buruk bagi kehidupan manusia. Semula teknologi hanya melanjutkan usaha manusia untuk mempelajari hukum-hukum alam agar alam dapat dimanfaatkan untuk memenuhi kebutuhan manusia. Akan tetapi semakin teknologi maju dan manusia menguasai alam, manusia mengalami kebalikan: manusia tidak lagi dapat menguasai akibat-akibat teknologinya sendiri.