bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epi-Clock: A sensitive platform to help understand pathogenic disease outbreaks and facilitate the response to future outbreaks of concern.
Authors: Ji Cong , Shao Junbin (Jack) 
Published: September 2022

Abstract
Background
The lack of virus fossilization precludes any references or ancestors for inferring evolutionary processes, and viruses have no cell structure, metabolism, or space to reproduce outside host cells. Most mutations yielding high pathogenicity go extinct from the population, but adaptive mutations could be epidemically transmitted and fixed in the population. Therefore, determining how viruses originated, how they diverged and how an infectious disease was transmitted are serious challenges.
Results
Surprisingly, some inter-species genetic distances of Coronaviridae were shorter than the intra-species distances, which may represent the intermediate states of different species or subspecies in the evolutionary history of Coronaviridae. The insertions and deletions of whole genome sequences between different hosts were separately associated with new functions or turning points, clearly indicating their important roles in the host transmission and shifts of Coronaviridae. Furthermore, we believethat non-nucleosomal DNA may play dominant roles in the divergence of different lineages of SARS-CoV-2 in different regions of the world because of the lack of nucleosome protection. We suggest that strong selective variation among different lineages of SARS-CoV-2 is required to produce strong codon usage bias. Interestingly, we found that an increasing number ofother types of substitutions, such as those resulting from the hitchhiking effect, have accumulated, especially in the pre-breakout phase, even though some previous substitutions were replaced by other dominant genotypes. To predict potential epidemic outbreaks, we tested our strategy, Epi-Clock, which applies the ZHU algorithm on different SARS-CoV-2datasets before outbreaks to search for real significant mutational accumulation patterns correlated with the outbreak events. Here, we imagine that specific amino acid substitutions would be triggers for outbreaks. From most validations, we could accurately predict the potential pre-phase of outbreaks with amedian interval of5 days before the outbreaks. Using our pipeline, users may review updated information on the website https://bioinfo.liferiver.com.cnwith easy registration.
Conclusions
Tracking the spread of infectious diseases to assist in their control has traditionally relied on the analysis of case data gathered as the outbreak proceeds. Here,we propose Epi-Clock, a sensitive platform to help understand pathogenic disease outbreaks and facilitate the response to future outbreaks, similar to a clock that can signal the need to assist individuals at focal locations by using diagnostics, isolation control, vaccines or therapy at any time.
Therapeutic hypothermia combined with hydrogen sulfide treatment attenuated early blood–brain barrier disruption and brain edema induced by cardiac arrest and resuscitation in rat model
Authors: Cai Shenquan , Li Qian , Fan Jingjing , Zhong Hao , Cao Liangbin , Duan Manlin 
Published: September 2022

Abstract
Brain injury remains a major problem in patients suffering cardiac arrest (CA). Disruption of the blood-brain barrier (BBB) is an important factor leading to brain injury. Therapeutic hypothermia is widely accepted to limit neurological impairment. However, the efficacy is incomplete. Hydrogen sulfide (H2S), a signaling gas molecule, has protective effects after cerebral ischemia/reperfusion injury. This study showed that combination of therapeutic hypothermia and hydrogen sulfide after resuscitation was more beneficial for attenuated BBB disruption and brain edema than that of hypothermia or hydrogen sulfide treatment alone. CA was induced by ventricular fibrillation for 4 minutes. Therapeutic hypothermia was performed by applying alcohol and ice bags to the body surface under anesthesia. We used sodium hydrosulphide (NaHS) as the H2S donor. Here, we found that global brain ischemia induced by CA and CPR resulted in brain edema and BBB disruption; therapeutic hypothermia or H2S treatment diminished brain edema, decreased the permeability and preserved the structure of BBB during the early period of CA and resuscitation, and more importantly, improved the neurologic function, increased the 7-day survival rate after resuscitation; the combination of therapeutic hypothermia and H2S treatment was more beneficial for reducing BBB permeability and brain edema than that of hypothermia or H2S treatment alone. The beneficial effects were associated with the inhibition of matrix metalloproteinase-9 (MMP-9) expression, attenuated the degradation of the tight junction protein occludin, and subsequently protected the structure of BBB. These findings suggest that combined use of hypothermia and H2S treatment during resuscitation of cardiac arrest patients could be a potential strategy to improve clinical outcomes and survival rate.
Evaluation of Skindex-16 construct validity in routinely collected psoriasis data: A retrospective analysis of the relationship between Overall Physician Global Assessment scores and Skindex-16 and measure discordance
Authors: Hopkins Zachary , Kuceki Guilherme , Taliercio Vanina , Snyder Ashley , Stoddard Greg J , Duffin Kristina C. , Hess Rachel , Secrest Aaron M. 
Published: September 2022

Abstract
Patient-reported outcome measures (PROMs) capture disease severity metrics from the patient’s perspective, including health-related quality of life (HRQL). Disease-specific validation of PROMs improves their clinical utility. We evaluated construct validity (HRQL) for Skindex-16 in routinely seen psoriasis patients and characterized instances of discordance between Skindex-16 scores and clinician reported outcome measure of disease severity. We retrospectively studied psoriasis patients seen by University of Utah Dermatology from 2016 to 2020. Cross-sectional construct validity was assessed using quantile regression and Spearman correlation between overall physician global assessment (OPGA) score and Skindex-16 scores. Longitudinal, within-subject correlation was performed using linear mixed models. Discordance (10th percentile or lower OPGA and 90th percentile or higher Skindex-16 score [clear skin, poor HRQL; cspHRQL] or the reverse [severe skin, good HRQL; ssgHRQL]) was characterized descriptively. 681 first-visit patients with psoriasis were included. Median overall Skindex-16 score varied by ≥ 10 points across all levels of OPGA scores. OPGA and Skindex-16 domain scores were moderately correlated (emotions ρ = 0.54, functioning ρ = 0.47, and symptoms ρ = 53). Longitudinal correlations were similar (emotion ρxy = 0.54, functioning ρxy = 0.65, symptoms ρxy = 0.47). Visits with cspHRQL discordance occurred for each Skindex-16 domain (emotions = 7, functioning = 13, symptoms = 12). The ssgHRQL group was observed within the emotions (n = 1) and functioning (n = 23) domains. Median Skindex-16 scores are different between different levels of OPGA and show moderate cross-sectional and longitudinal correlation. This supports construct validity in patients with psoriasis. Severe discordance was rare and most often for those with clear skin but poor HRQL. These discordances can prompt further patient-clinician conversation.
Moroccan consumers purchasing behaviors toward the sustainability of cosmetics today
Authors: Oukerrou Marwa 
Published: September 2022

Abstract
The purchase of green and sustainable products has become a necessary step toward the protection of the environment. There are many reasons that push consumers to purchase green, sustainable products: personal, psychological, social, cultural, or economic. There are also some impediments that keep them away from purchasing those products, like the value of the product, its usage, risks of usage, the consumer’s traditions or the product’s image. Based on a survey of 100 responses on purchasing green sustainable cosmetics by Moroccan consumers today, and analyzing the results using the descriptive analysis, to understand and determine the reasons and motivations or disincentives that influence their purchasing behavior of green cosmetics. The results reveal that personal, economic, and social factors are what lead them to purchase, while low quality of usage, the product’s value in performance and price, and the risks that can come from using unknown products labeled green or sustainable can lead Moroccan consumers to not purchase those products.
MNCR and JPX lncRNAs have a significant oncogenic and biomarker role in the Isfahan Breast cancer population by regulating the MYC expression level: An integrated bioinformatics and experimental approach
Authors: Nazempour Nasrin , Shakarami Maryam , Tavakolikia Fatemeh , Heidari Hadis , Omidghaemi Shadi , Azadeh Mansoureh 
Published: September 2022

Abstract
long non-coding RNAs play essential roles in the regulation of the gene’s expression level. The abnormal difference in the gene expression and transcriptome amount in the cells can make the various diseases in the human, including cancer. In this study, the expression of MYC and the two relevant and co-expressed lncRNAs were analyzed in the breast cancer (BC) samples as the potential BC biomarkers. An integrated bioinformatics analysis – including Microarray, RNA interaction, Pathway enrichment, and Gene ontology analyses – was performed to find novel differentially expressed genes in the BC patients. A real-time PCR experiment evaluated the expression of potential BC biomarkers found in the bioinformatics analyses. Bioinformatics and experimental analyses revealed that MINCR and JPX have a remarkable up-regulation in the BC samples and can be the two BC oncogene. Also, it is demonstrated that MYC could act as a tumor suppressor in BC patients by low-expression in the BC samples. All in all, the changes in the expression of MYC – affected by MINCR and JPX – can promote breast cancer pathogenicity. These three coding and non-coding RNAs can act as the acceptable prognostic biomarkers in BC.
Calcaneal osteotomy due to insertional calcaneal (Achilles) tendinopathy – preoperative planning
Authors: Mazura Matej , Goldman Tomas , Popelka Stanislav , Kachlik David , Hromadka Rastislav 
Published: September 2022

Abstract
Purpose
Dorsal closing wedge calcaneal osteotomy (DCWCO) is indicated in patients with insertional tendinopathy of the calcaneal (Achilles) tendon. The Chauveaus-Liet's (CL) angle is represented by the difference between the angle of verticalization (α) and morphological angle (β) of the calcaneus (CL angle = α − β). The purpose of the study was to assess whether the DCWCO affects the Chauveaus-Liet's angle.
Methods
The study included 12 patients indicated to DCWCO. Three directions of close wedge osteotomy were designed for each patient—horizontal, vertical and in the middle type of osteotomy and a virtual osteotomy was created in each of them in the ABAQUS system in cooperation with Czech Technical University. The most used directions of osteotomy according to the available literature were used. We evaluated α and β angles before and after osteotomy, changes of the length plantar aponeurosis and the elevation of distal insertional point of the calcaneal tendon. The changes of grades, median and standard deviation were observed.
Results
The change of the alfa angle was dependent on the direction of the osteotomy and the change of the beta angle was affected by the size of the osteotomy. The greatest elevation of the distal insertional point of the calcaneal tendon occurred in the horizontal type of the osteotomy.
Conclusion
Our study shows that the more we want to reduce the tension in the calcaneal tendon, the more we have to perform an osteotomy horizontally. This study could serve as a preoperative guide for osteotomy planning.
Sb loaded MnOx/TiO 2 /CNTs catalysts for Selective catalytic reduction of NOx: insight to the SO 2 and H 2 O tolerance
Authors: Natarajan S , Raja S , Pitchandi K , Sivachandiran L 
Published: September 2022

Abstract
A series of Sb containing CNTs based MnOx/TiO2 catalysts were prepared by the incipient wetness co-impregnation method and tested for the selective catalytic reduction (SCR) of NOx with NH3. The Sb loaded MnOx/TiO2-CNTs catalyst showed better performance than the other catalysts tested and presented the highest activity in the temperature regime of 100–400 oC. Interestingly, Sb loaded catalyst exhibited SO2 and H2O resistance with better thermal stability. Physico-chemical characterizations such as SEM, XRD, BET, XPS, NH3-TPD, and H2-TPR were employed to investigate the influence of Sb loading on NOx removal over MnOx/TiO2-CNTs catalysts. A step-wise addition of SO2 into the gas stream disclosed that MnOx-Sb/TiO2-CNTs catalyst has better SO2 resistance by avoiding the sulphur poisoning than the base catalyst MnOx/TiO2. Moreover, the results of SEM and XRD revealed that the dispersion of MnOx on TiO2/CNT surface was more uniform after Sb loading. We evidenced that the decrease in SCR activity of MnOx based catalyst is due to the formation of MnSO4. Indeed, in Sb loaded catalysts, the SOx species react more preferably with SbOx than that of MnOx. This strong interaction of SO2 with SbOx successfully prevents the poisoning of active sites on MnOx from being sulphated. This significantly improved the SO2 tolerance of Sb-loaded catalysts.
Treatment options and the management of complications in hydatid cysts of the liver in endemic regions
Authors: Daduk Yildiray , Seker Ahmet , Sozutek Alper , Olmez Tolga , Kaplan Kuntay , Dur Huseyin , Ozdemir Gorkem 
Published: September 2022

Abstract

Aim
Due to the limited applicability of PAIR, we think that surgery is the most effective treatment at every stage, especially in endemic regions, depending on patient-related factors.
Method
Patients with hydatid cyst of the liver treated with PAIR and surgery in our center between January 2016 and January 2022 were analyzed retrospectively. PAIR or cystectomy were applied in treatment. It was compared in terms of efficacy, feasibility, and complications.
Results
A single hydatid cyst of the liver was detected in 184 of the 225 cases, two cysts in 34, and three or more cysts in eight. While the largest cyst diameter was 233*124 mm in those who underwent surgery, it was 100*90 mm in PAIR. One hundred thirty-three of the 225 patients underwent open surgery, and no recurrence was encountered. However, recurrence was observed 19 patients treated with PAIR. Allergic reaction developed in one case during surgery, postoperative abscess in two cases, biliary fistula in five and pneumonia in one.
Conclusion
Surgical treatment should represent the standard procedure since it is safe and effective and ensures complete elimination of the parasite, involves no intraoperative shedding, preserves healthy tissues, and minimizes the risk of long-term recurrence and cavity-related complications.
Relativity and View Effects
Authors: Fischli Bernard 
Published: September 2022

Abstract
This paper describes a new interpretation of relativity. The concept of rest frames of the observer and the object clarifies the initial assumptions used in General Relativity and underlines the necessity to review whatever impacts relativity. Relativistic view effects, calculated using reciprocal Lorentz factors and deflecting the paths of photons, are examined in addition to interactions. The Ehrenfest paradox is solved, and it is not compatible with a curved space. View effects specific to each point of view are the solution. The concept of a seen speed is introduced. The calculation of the deflection of light by the sun explains in detail why the deflection angle must be double the value obtained with Newton’s laws. This is due to gravitation as well as to relativistic view effects. As already noted by Einstein the deflection of light can only take place if the speed of light varies in vacuum. This is done by gravitation. The compatibility of General Relativity with the new interpretation is discussed. The main argument for this compatibility is due to the use in General Relativity of a Pseudo-Riemannian geometry describing intrinsic views which introduce the rest frame concept. They are compatible with view effects. Differences subsist mainly regarding energy. Relativistic energy is examined. The relationship of Special Relativity between speed and energy is confirmed for electromagnetism where path speeds are limited to the speed of light. Such speed limits do not apply to gravitation where total energy is composed of rest mass energy plus a kinetic energy as defined in classical mechanics. When gravitation acts on objects that transfer their path information by light, the paths of the photons will be deflected by relativistic view effects modifying that information. View effects are optical illusions interpreted in General Relativity as interactions introducing dark energy.
A case study on integrated management of water losses in Antalya, Turkey
Authors: Akdeniz Tugba 
Published: September 2022

Abstract
In this study, effects of the combination of meter replacement and active leakage control on real and apparent losses are investigated. Generally, water meter replacement campaigns, SCADA system operation, data analysis studies and physical leak detection activities are carried out by different units in water utilities. Within the scope of this study, the studies carried out by different units of the water utility were carried out in an integrated manner in the same period and the obtained data sets were analysed together. Thus, water losses, which were at the level of 52% in the pilot study area (PSA), were reduced to 35%. When the volumes of water supplied to the system before and after the study are compared, the volumes after the study were decreased. Also, water losses in the PSA have been reduced by 17%.
Membrane-free electrodeionization using graphene composite electrode to purify copper-containing wastewater
Authors: Shen Xiaolan , Liu Qi , Li Hao , Kuang Xinmou 
Published: September 2022

Abstract
Membrane-free electrodeionization (MFEDI) technology involves in situ electric regeneration of ion exchange resin, and is used to efficiently purify copper-containing wastewater, so that both the wastewater and copper may be reused. The electrode is the core functional component of a MFEDI system. Electrode-selection greatly influences the electric regeneration efficiency, water recovery and energy consumption of MFEDI processes. In this study, a graphene composite electrode was developed to improve MFEDI-system performance. A graphene composite electrode and conventional platinum-plated titanium electrode were both characterized by scanning electron microscopy (SEM) and electrochemical testing. Furthermore, the treatment and electrical regeneration properties of MFEDI systems with these two electrodes were investigated. The specific surface area of the electrode increased after graphene loading, while the oxygen evolution potential decreased. Wastewater treatment experiments demonstrated that MFEDI systems with graphene composite electrodes effectively removed copper from wastewater. The study also highlighted that the electroregeneration efficiency of the MFEDI system was improved by loading with graphene; the average copper concentration in the regeneration solution increased by 1.4 times to 50.4 mg/L, while the energy consumption decreased from 1.55 to 1.48 kWh/m3, and the water recovery rate increased from 85 to 90%.
Interactions of Copper(II) and Zinc(II) Ions with the Peptide Fragments
of Proteins Related to Neurodegenerative Disorders: Similarities
and Differences
Authors: Sóvágó Imre , Várnagy Katalin , Kállay Csilla , Grenács Ágnes 
Published: September 2022

Abstract:
Metal binding ability and coordination modes of the copper(II) and zinc(II)
complexes of various peptide fragments of prion, amyloid-β, and tau proteins, are summarized
in this review. Imidazole-N donors are the primary metal binding sites of all
three proteins, but the difference in the location of these residues and the presence or
absence of other coordinating side chains result in significant differences in the complex
formation processes. The presence of macrochelates and the possibility of forming multicopper
complexes are the most important characteristic of prion fragments. Amyloid-β
can form highly stable complexes with both copper(II) and zinc(II) ions, but the preferred
binding sites are different for the two metal ions. Similar observations are obtained
for the tau fragments, but the metal ion selectivity of the various fragments is even more
pronounced. In addition to the complex formation, copper(II) ions can play an important
role in the various oxidative reactions of peptides. Results of the metal ion-catalyzed oxidation
of peptide fragments of prion, amyloid-β, and tau proteins are also summarized.
Amino acid side chain oxidation (mostly methionine, histidine and aspartic acid) and protein
fragmentations are the most common consequences of this process.
An Overview of Ruthenium-Catalyzed Multicomponent Reactions
Authors: Saranya Padinjare Veetil , Neetha Mohan , Afsina C.M.A. , Anilkumar Gopinathan 
Published: September 2022

Abstract:In multicomponent reactions (MCRs), highly functionalized compounds can be formed through the reaction between three or more reactants in a one-pot manner. These reactions provide products through the utilization of lesser amounts of energy, time, and effort. MCRs also possess advantages like the generation of lesser waste materials. Fewer resources are needed, high convergence etc. In terms of energy economy and atom economy, MCRs are superior to multistep synthesis. A wide range of products can be acquired by combining the reagents in a variety of ways and thus, MCRs became popular in various fields such as catalysis, pharmaceutical chemistry, material science, agrochemistry, fine chemistry and so on. MCRs obey the principles of green chemistry because these approaches are simple and ecofriendly. MCR is an unrivalled synthetic technique and has been used by chemists at an accelerating rate in recent years. Ruthenium catalysts are cheap in comparison to palladium and rhodium, and generally show high activity. Ru possesses wide-ranging oxidation states due to its 4d7 5s1 electronic configuration. Numerous organic reactions are catalyzed by ruthenium, which are utilized in forming a wide range of pharmaceuticals and natural products, with biological importance. Minimum amounts of waste materials are formed in most of the ruthenium-catalyzed reactions; hence, ruthenium catalysis paves the way to environmentally benign protocols. Ruthenium chemistry has had a really big impact on organic synthesis in recent years and it is now on par with palladium in terms of relevance. The developments in the field of ruthenium-catalyzed multicomponent reactions are highlighted in this review, covering the literature up to 2021.