bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cationic P,O‐Coordinated Nickel(II) Catalysts for Carbonylative Polymerization of Ethylene: Unexpected Productivity via Subtle Electronic Variation
Authors: Chen Shi‐Yu , Ren Bai‐Hao , Li Shi‐Huan , Song Yu‐Hang , Jiao Shuang , Zou Chen , Chen Changle , Lu Xiao‐Bing , Liu Ye 
Published: May 2022

AbstractTransition‐metal‐catalyzed copolymerization of ethylene with carbon monoxide affords polyketones materials with excellent mechanical strength, photodegradability, surface and barrier properties. Unlike the widely used and rather expensive Pd catalysts, Ni‐catalyzed carbonylative polymerization is very difficult since the strong binding affinity of CO to Ni deactivates the highly electrophilic metal center easily. In this study, various cationic P,O‐coordinated Ni complexes were synthesized using the electronic modulation strategy, and the catalyst with strong electron‐donating substituents exhibits an excellent productivity of 104 g polymer (g Ni)−1, which represents a rare discovery that a Ni complex could operate with such exceptional efficiency in comparison with Pd catalysts. Notably, those Ni catalysts were also efficient for terpolymerization of ethylene, propylene with CO for producing commercial polyketone materials with low melting temperatures and easy processibility.
Oxadiazole: A highly versatile scaffold in drug discovery
Authors: Desai Nisheeth , Monapara Jahnvi , Jethawa Aratiba , Khedkar Vijay , Shingate Bapurao 
Published: May 2022

AbstractAs a pharmacologically important heterocycle, oxadiazole paved the way to combat the problem associated with the confluence of many commercially available drugs with different pharmacological profiles. The present review focuses on the potential applications of five‐membered heterocyclic oxadiazole derivatives, especially 1,2,4‐oxadiazole, 1,2,5‐oxadiazole, and 1,3,4‐oxadiazole, as therapeutic agents. Designing new hybrid molecules containing the oxadiazole moiety is a better solution for the development of new drug molecules. The designed molecules may accumulate a biological profile better than those of the drugs currently available on the market. The present review will guide the way for researchers in the field of medicinal chemistry to design new biologically active molecules based on the oxadiazole nucleus. Antitubercular, antimalarial, anti‐inflammatory, anti‐HIV, antibacterial, and anticancer activities of various oxadiazoles have been reviewed extensively here.
Nickel oxide hollow microsphere for the chemiluminescence determination of tuberculostatic drug isoniazid
Authors: Hassanpour‐Khaneghah Mahdiyeh , Iranifam Mortaza , Naseri Abdolhossein , Al Lawati Haider A. J. 
Published: May 2022

AbstractIn this article, nickel(II) oxide (NiO) hollow microspheres (HMSs) were fabricated and used to catalyze chemiluminescence (CL) reaction. The studied CL reaction is the luminol‐oxygen reaction that was used as a sensitive analytical tool for measuring tuberculostatic drug isoniazid (IND) in pharmaceutical formulations and water samples. The CL method was established based on the suppression impact of IND on the CL reaction. The NiO HMSs were produced by a simple hydrothermal method and characterized by several spectroscopic techniques. The result of essential parameters on the analytical performance of the CL method, including concentrations of sodium hydroxide (NaOH), luminol, and NiO HMSs were investigated. At the optimum conditions, the calibration curve for IND was linear in the range of 8.00 × 10−7 to 1.00 × 10−4 mol L−1 (R2 = 0.99). A detection limit (3S) of 2.00 × 10−7 mol L−1 was obtained for this method. The acceptable relative standard deviation (RSD) was obtained for the proposed CL method (2.63%, n = 10) for a 5.00 × 10−6 mol L−1 IND solution. The mechanism of the CL reaction was also discussed.
Psychotherapists' efforts to increase awareness of social privilege
Authors: Brown Jason , Lengyell Marguerite 
Published: May 2022

AbstractUnderstanding the role of privilege in systemic oppression positions psychotherapists to engage in culturally oriented practice. Twenty‐five practising psychotherapists were asked: ‘How can psychotherapists increase their awareness of social privilege?’ Participants sorted 68 unique responses into six concepts. The concepts included: make yourself uncomfortable; embrace humility; learn from the community; involvement in social action; seek critical knowledge; and find like‐minded others in the profession. Recommendations for student training are offered.
Chemical Diversity and Biosynthesis of Drimane‐Type Sesquiterpenes in the Fungal Kingdom
Authors: Huang Ying , Valiante Vito 
Published: May 2022

AbstractDrimane‐type sesquiterpenes are a class of compounds produced by a wide range of organisms, initially isolated and characterized in plants. Meanwhile, in the past 20–30 years, a large number of novel structures from many divergent fungi have been elucidated. Recently, the biosynthesis of drimane‐type sesquiterpenes and their esters has been explained in two filamentous fungi, namely Aspergillus oryzae and Aspergillus calidoustus, disclosing the basic biosynthetic principles needed to identify similar pathways in the fungal kingdom.
Decidual stromal cell therapy for generalized lymphadenopathy as a special clinical manifestation of COVID‐19 infection: A case report
Authors: Pirsalehi Ali , Soleimani Masoud , Hajifathali Abbas , Sadeghi Behnam , Farhadihosseinabadi Behrouz , Akhlaghi Sedigheh Sadat , Roshandel Elham 
Published: May 2022

AbstractWe are going through the greatest global health crisis of the last decades, the coronavirus disease 2019 (COVID‐19) pandemic. It may cause morbidity and mortality in some cases, and there is no therapeutic approach with reproducible and favorable outcomes. As clinical manifestations differ from patient to patient, any report regarding clinical symptoms has been beneficial for early detection and treatment. Due to the immunomodulatory effect of mesenchymal stem cells (MSCs), MSCs‐based therapy has been approved to be one of the therapeutic strategies for COVID‐19 management. For the first time in the literature, we reported generalized lymphadenopathy with fever and no sign of respiratory distress in a 16‐year‐old patient with confirmed COVID‐19 infection as the main clinical signs. We also introduce decidual stromal cells as a potential immunomodulatory treatment for COVID‐19–infected patients.
Urinary bladder cavernous hemangioma in a 3‐year‐old: A rare case report
Authors: Odongo Charles Newton , Atwine Raymond , Kirya Fred , Okello Patrick Ambrose , Ogwang Eugene , Acan Moses , Bongomin Felix , Situma Martin 
Published: May 2022

AbstractCavernous hemangioma (CH) of urinary bladder occurs relatively infrequently, accounting for 0.6% of all bladder tumors. This tumor may occur sporadically or coexist with other benign and malignant vascular lesions. In this report, we present a rare case of CH in a 3‐year‐old Ugandan girl. A 3‐year‐old girl was referred to Mbarara Regional Referral Hospital (MRRH) for urological evaluation following a 3‐year history of intravaginal swelling, dysuria, and heavy hematuria resulting in anemia. Imaging was consistent with polypoid bladder mass arising from the bladder trigone. Embryonal rhabdomyosarcoma was suspected based on clinical eyeballing. She was worked up for chemotherapy and received 26 cycles of vincristine sulfate, actinomycin‐d, and cyclophosphamide (VAC). Biopsy and fulguration were performed after optimizing the patient. Histopathology confirmed CH. The surgery was uneventful and resulted in complete cure. CH should be considered in the differential diagnosis of childhood genitourinary masses. It is a rare entity in the real‐life clinical practice and therefore can be overlooked. Excision biopsy and histology should be performed before initiating the patients to chemotherapy. CH is very insensitive to chemotherapy and therefore surgery maybe adequate in resource‐limited settings.
High‐Performance Polyimide Nanofiber Membrane for Progressive and Safe Lithium‐Ion Batteries Guarded by a Zirconia Armor Layer
Authors: Li Xiaogang , Liu Kefan , Dong Nanxi , Wang Ruihan , Li Tengfei , Liu Bingxue , Qi Shengli , Wu Dezhen 
Published: May 2022

AbstractInnovative technologies for the fabrication of separators possessing outstanding properties like superior thermostability, mechanical strength, and ultrahigh flame resistance are imperative for advanced and safe energy storage systems (ESSs). Nevertheless, there are lots of limitations to attain the requirements mentioned above for classic polymeric separators. Herein, to achieve all these goals, we fabricate a zirconia nanoshell@polyimide core formed in situ (ZrO2@PI in situ) as a nanofabric membrane via an innovative and convenient strategy to be used as a novel high‐performance flexible ceramic composite separator. Different from traditional ceramic‐coated separators, the in situ ZrO2@PI composite separator possesses a shell‐core structure obtained via an in situ absorption complexation and hydrolysis strategy, which endows ultrahigh flame resistance, superior wettability, thermostability, and excellent ionic conductivity. The NCM811 batteries installed with an in situ ZrO2@PI nanofabric separator displays the outstanding capacity of 159.0 mAh g−1 at 5 C, far higher than the cells assembled with a PI separator (146.2 mAh g−1) or Celgard‐2400 separator (125.1 mAh g−1) at the same 5 C. In addition, the cell manifests outstanding cycle performance, for which the capacity retention ratio is 89.4 % after 100 cycles at 1 C. All test results certify the ZrO2@PI composite separators formed in situ can be effectively applied in progressive and safe batteries.
A Multi‐Functional Separator for Li‐S Batteries: WS2@C Nanoflowers Catalyze the Rapid Recycling of Lithium Polysulfides by Polar Attraction
Authors: Xie Fanxuan , Xiong Man , Liu Jiapeng , Qian Jingwen , Mei Tao , Li Jinghua , Wang Jianyin , Yu Li , Hofmann Jan P. , Wang Xianbao 
Published: May 2022

AbstractFeaturing high theoretical capacity, environmental friendliness and low cost, lithium‐sulfur (Li‐S) batteries become promising alternatives to satisfy the growing demand for energy storage. To boost their energy density for practical application, modified separators are needed to suppress shuttle effects resulting from the solubility of lithium polysulfides (LiPSs). Herein, we modified traditional polypropylene (PP) separators with functional WS2@C nanoflower composites (WS2@C‐PP). They can effectively adsorb LiPSs and catalyze their conversion on the edge sites of the WS2. Also, the unique construction of a carbon layer coating on the WS2 nanoflowers combines active sites and conducting properties. The material benefits the reversibility of redox reactions and reutilization of active materials. With the WS2@C‐PP separator, the cell displays improved cycling stability and rate performance. When cycling at 0.1 C, the cell discharges a capacity of up to 1475 mAh g−1, and it contributes 943 mAh g−1 originally at 1 C, with a decay rate of only 0.07 % after 500 cycles. Our work highlights the potential of functional separators to advance the properties of Li‐S batteries.
Chemically Modified Poly(A) Analogs Targeting PABP: Structure Activity Relationship and Translation Inhibitory Properties
Authors: Perzanowska Olga , Smietanski Miroslaw , Jemielity Jacek , Kowalska Joanna 
Published: May 2022

AbstractPoly(A)‐binding protein (PABP) is an essential element of cellular translational machinery. Recent studies have revealed that poly(A) tail modifications can modulate mRNA stability and translational potential, and that oligoadenylate‐derived PABP ligands can act as effective translational inhibitors with potential applications in pain management. Although extensive research has focused on protein‐RNA and protein‐protein interactions involving PABPs, further studies are required to examine the ligand specificity of PABP. In this study, we developed a microscale thermophoresis‐based assay to probe the interactions between PABP and oligoadenylate analogs containing different chemical modifications. Using this method, we evaluated oligoadenylate analogs modified with nucleobase, ribose, and phosphate moieties to identify modification hotspots. In addition, we determined the susceptibility of the modified oligos to CNOT7 to identify those with the potential for increased cellular stability. Consequently, we selected two enzymatically stable oligoadenylate analogs that inhibit translation in rabbit reticulocyte lysates with a higher potency than a previously reported PABP ligand. We believe that the results presented in this study and the implemented methodology can be capitalized upon in the future development of RNA‐based biological tools.
Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform
Authors: Gérardy Romaric , Nambiar Anirudh M. K. , Hart Travis , Mahesh Prajwal T. , Jensen Klavs F. 
Published: May 2022

AbstractThe implementation of self‐optimizing flow reactors has been mostly limited to model reactions or known synthesis routes. In this work, a self‐optimizing flow photochemistry platform is used to develop an original synthesis of the bioactive fragment of Salbutamol and derivatives. The key photochemical steps for the construction of the aryl vicinyl amino alcohol moiety consist of a C−C bond forming reaction followed by an unprecedented, high yielding (>80 %), benzylic oxidative cyclization.
Mycophenolate mofetil for immune checkpoint inhibitor‐related hepatotoxicity relapsing during dose reduction of corticosteroid: A report of two cases and literature review
Authors: Ueno Masayuki , Takabatake Hiroyuki , Hata Ayako , Kayahara Takahisa , Morimoto Youichi , Notohara Kenji , Mizuno Motowo 
Published: May 2022

AbstractBackgroundImmune checkpoint inhibitors (ICIs) sometimes cause immune‐related liver injury, which can lead to cessation of treatment, hospitalization, and even mortality. Although high‐dose corticosteroids are usually effective in treatment of ICI‐related liver injury, one fifth of affected patients require additional immunosuppressive therapy. It remains uncertain how best to treat ICI‐related liver injury that relapses under corticosteroid therapy after temporary remission.CaseHere we report two cases of ICI‐related liver injury successfully treated with mycophenolate mofetil (MMF). In the first case, a 74‐year‐old man with stage IIIA lung cancer underwent curative chemoradiotherapy. After the second infusion of durvalumab, grade 3 ICI‐related liver injury (mixed pattern) developed. In the second case, a 46‐year‐old man with stage IVB lung cancer received pembrolizumab‐containing chemotherapy. After the first cycle, grade 2 ICI‐related hepatitis developed. In the both cases, liver injury improved with high‐dose prednisolone but relapsed during tapering of the drug. After liver biopsy was performed to confirm the diagnosis of ICI‐related liver injury, MMF (2000 mg/day) was added. MMF was effective for both patients and permitted discontinuation or reduction of prednisolone.ConclusionMMF appears to be an appropriate treatment option for ICI‐related liver injury that respond to high‐dose corticosteroids but relapse during steroid tapering.
Night‐to‐night variation in sleep associates with day‐to‐day variation in vigilance, cognition, memory, and behavioral problems in Alzheimer's disease
Authors: Balouch Sara , Dijk Dylan A.D. , Rusted Jennifer , Skene Simon S. , Tabet Naji , Dijk Derk‐Jan 
Published: May 2022

AbstractIntroductionSleep disturbances are commonly reported in people living with Alzheimer's disease (AD), but it is currently unknown whether night‐to‐night variation in sleep predicts day‐to‐day variation in vigilance, cognition, mood, and behavior (daytime measures).MethodsSubjective and objective sleep and daytime measures were collected daily for 2 weeks in 15 participants with mild AD, eight participants with mild cognitive impairment (MCI), and 22 participants with no cognitive impairment (NCI). Associations between daytime measures and four principal components of sleep (duration, quality, continuity, and latency) were quantified using mixed‐model regression.ResultsSleepiness, alertness, contentedness, everyday memory errors, serial subtraction, and behavioral problems were predicted by at least one of the components of sleep, and in particular sleep duration and continuity. Associations between variations in sleep and daytime measures were linear or quadratic and often different between participants with AD and those with NCI.DiscussionThese findings imply that daytime functioning in people with AD may be improved by interventions that target sleep continuity.
CD11c identifies microbiota and EGR2‐dependent MHCII+ serous cavity macrophages with sexually dimorphic fate in mice
Authors: Bain Calum C. , Louwe Pieter A. , Steers Nicholas J. , Bravo‐Blas Alberto , Hegarty Lizi M. , Pridans Clare , Milling Simon W.F. , MacDonald Andrew S. , Rückerl Dominik , Jenkins Stephen J. 
Published: May 2022

AbstractThe murine serous cavities contain a rare and enigmatic population of short‐lived F4/80loMHCII+ macrophages but what regulates their development, survival, and fate is unclear. Here, we show that mature F4/80loMHCII+ peritoneal macrophages arise after birth, but that this occurs largely independently of colonization by microbiota. Rather, microbiota specifically regulate development of a subpopulation of CD11c+ cells that express the immunoregulatory cytokine RELM‐α, are reliant on the transcription factor EGR2, and develop independently of the growth factor CSF1. Furthermore, we demonstrate that intrinsic expression of RELM‐α, a signature marker shared by CD11c+ and CD11c– F4/80loMHCII+ cavity macrophages, regulates survival and differentiation of these cells in the peritoneal cavity in a sex‐specific manner. Thus, we identify a previously unappreciated diversity in serous cavity F4/80loMHCII+ macrophages that is regulated by microbiota, and describe a novel sex and site‐specific function for RELM‐α in regulating macrophage endurance that reveals the unique survival challenge presented to monocyte‐derived macrophages by the female peritoneal environment.
Molecular Iodine‐Catalysed Reductive Alkylation of Indoles: Late‐Stage Diversification for Bioactive Molecules
Authors: Cheng Xionglve , Wang Lili , Liu Yide , Wan Xiao , Xiang Zixin , Li Ruyi , Wan Xiaobing 
Published: May 2022

AbstractHerein, we report a molecular iodine‐catalysed reductive alkylation of indoles with carbonyl compounds using Et3SiH for the efficient synthesis of C3‐alkylated indoles. This metal‐free and environmental‐friendly process exhibits excellent functional group tolerance, mild conditions, and wide substrate scope. Notably, the synthetic usefulness of this strategy to pharmacochemistry was highlighted by the late‐stage modification of drug‐like molecules.
CurFi: An automated tool to find the best regression analysis model using curve fitting
Authors: Roy Ayon , Al Zubayer Tausif , Tabassum Nafisa , Islam Muhammad Nazrul , Sattar Md. Abdus 
Published: May 2022

AbstractRegression analysis is a well known quantitative research method that primarily explores the relationship between one or more independent variables and a dependent variable. Conducting regression analysis manually on large datasets with multiple independent variables can be tedious. An automated system for regression analysis will be of great help for researchers as well as non‐expert users. Thus, the objective of this research is to design and develop an automated curve fitting system. As outcome, a curve fitting system named “CurFi” was developed that uses linear regression models to fit a curve to a dataset and to find out the best fit model. The system facilitates to upload a dataset, split the dataset into training set and test set, select relevant features and label from the dataset; and the system will return the best fit linear regression model after training is completed. The developed tool would be a great resource for the users having limited technical knowledge who will also be able to find the best fit regression model for a dataset using the developed “CurFi” system.
Kinematic response of vertical and batter pile groups in non‐linear soft soil
Authors: Cemalovic Miran , Husebø Jan B. , Kaynia Amir M. 
Published: May 2022

AbstractThis paper presents a comprehensive numerical study on kinematic response of vertical and batter pile groups in soft soil, where soil non‐linearity, batter angle, pile spacing and excitation frequency are related to pile‐cap displacements, rotations, maximum pile moments, shear forces and axial forces. The finite element model is constructed in OpenSees MP, and parallel computing is utilized for a better (faster) performance. Results reveal that soil non‐linearity has a profound impact on the kinematic interaction. Increasing batter angle decreases horizontal displacements but increases rotations. Batter pile groups yield lower spectral accelerations compared to vertical pile groups. For high , the spectral accelerations of the pile‐cap may be lower compared to the spectral acceleration of the seismic input motion. Estimation using non‐linear interaction factors conservatively estimates pile‐cap displacements and rotations, while roughly captures the effects with respect to batter angle and frequency content within the specified framework.
Strategizing and economizing in global strategy
Authors: Asmussen Christian Geisler , Foss Nicolai J. 
Published: May 2022

AbstractResearch summaryThe strategic management and international business fields have followed, in some respects, quite similar intellectual trajectories, as reflected in the push for a field of “global strategy.” However, a key distinction in the strategy literature—namely, Williamson's distinction between “strategizing” and “economizing”—has not been explicitly recognized in the international business/global strategy fields. We argue that progress can be made in global strategy by recognizing this distinction and exploring the interaction between “strategizing” and “economizing.” To lend credence to this claim, we offer a simple model of the entry decision which highlights both economizing and strategizing aspects of this decision. We also offer recommendations on economizing‐strategizing research in global strategy.Managerial summaryMultinational enterprises gain competitive advantage either by improving the efficiency with which they operate (by having unique resources, lowering costs, or improving managerial practices) or by exercising their market and bargaining power. Most research has emphasized the former source of competitive advantage. However, in actuality, the two sources are intertwined. We detail how they are intertwined by means of a simple numerical example of the entry decision facing a company that can choose between competing or collaborating with the local firm. We show that strategizing plays into the entry decision in this case.