bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of 25 Gy in 5 fractions of palliative radiotherapy for symptomatic pelvic tumors
Authors: Aoshika Tomomi , Abe Takanori , Iino Misaki , Saito Satoshi , Ryuno Yasuhiro , Ohta Tomohiro , Igari Mitsunobu , Hirai Ryuta , Kumazaki Yu , Noda Shin-ei , Kato Shingo 
Published: July 2022

Abstract
Background
Palliative radiotherapy is one of the effective treatments for pelvic tumor with bleeding or pain. In this study, we evaluated the safety and efficacy of palliative radiotherapy (RT) for symptomatic pelvic tumors when delivered as 25 Gy in 5 fractions.
Methods
We retrospectively analyzed 34 patients (gynecological cancer: n = 14, rectal cancer: n = 5, metastatic pelvic bone tumor: n = 7, metastatic pelvic lymph node tumor: n = 5, synovial sarcoma of the pelvis: n = 1, prostate cancer: n = 1, and urothelial cancer: n = 1, who were treated between July 2016 and July 2021. Their symptoms were bleeding in 16 patients, pain in 17 patients, and both bleeding and pain in 1 patient. Hemostatic effect of RT was evaluated with pre and post treatment hemoglobin (Hb) values. If the Hb level reached a nadir and increased thereafter, we considered that there is a hemostatic response. Pain was evaluated with a numerical rating scale (NRS) and treatment response was defined as a decrease in NRS.
Results
Their median follow-up period was 4 months. Hemostatic response was observed in 82% of patients (14 of 17 patients). Pain relief response was observed in 78% of patients (14 of 18 patients). Acute adverse effects (AEs) included grade 1 diarrhea: n = 3, grade 1 dermatitis: n = 1, and grade 1 urinary frequency: n = 1; late AEs were not observed so far.
Conclusions
We think that 25 Gy of palliative RT in 5 fractions seems to be safe and effective for symptomatic pelvic tumors, similar to conventional palliative RT schedules.
Isolation, identification and characterization of β-carotene producing endophytic fungi- Penicillium citrinum from bark of Taxus baccata
Authors: Nagal Shweta , Panda Bibhu Prasad 
Published: July 2022

Abstract
C40 carotenoids with the chain of conjugated double bonds are known antioxidants with specific biological activity. Besides the known microbes used for β-carotene, we isolated a new fungus from Taxus baccata tree and identified its carotenoid synthesizing property. Isolated unknown fungi with carotenoids biosynthetic property were identified at the species level by analysing its internal transcribed spacer (ITS) and 18S rDNA region. Confirmation of β-carotene synthesis was done using UV-vis spectroscopy where the three peak spectra (434, 456 and 482 nm) of β-carotene confirmed its presence. Also, the infra-red spectrum gave absorption at a certain frequency which is indicative of the abundance of carotenoids with the major functional group as C-H, CH3 and C = C bonding. MS data of analytes was observed using the electrospray ionization method (ESI) with triple quadrupole (TQD) mass spectrometer, which resulted in the elimination of functional group and production of precursors ions of different carotenoids. Mass spectra showed a high degree of fragmentation with characteristics peak of carotenoids at 536.9 (β-carotene), 538.9 (Zeacarotene), 544.4 (Phytoene), 554.0 (β-cryptoxanthin), 569.18 (Zeaxanthin) and standard characteristics peak 536.6 of β-carotene in standard as well as sample confirmed presence.
Manipulations of Libet clock parameters affect intention timing awareness
Authors: Ivanof Bianca E. , Terhune D. B. , Coyle D. , Moore J. W. 
Published: July 2022

Abstract
W judgments are a widely used intention timing awareness estimate. These judgments are typically obtained by using the classic Libet-style paradigm whereby participants are asked to estimate the time they become aware of their intention to act by using the location of a rotating object on a clock face. There is an inconsistency in the Libet clock parameters used in previous studies, and it is unclear whether this variability impacts W judgments and other outcome measures, with implications for the construct validity of this measure and generalisability of results across studies. Here, we present a four-experiment study that systematically manipulated the Libet clock speed, number of clock markings, length of the clock hand and type of clock radius in order to examine whether these parameter manipulations affect intention timing awareness estimates. Our results demonstrate W judgments can be significantly influenced by the clock speed and number of clock markings. The meaning and implications of these results are discussed.
Multiplexed and reproducible high content screening of live and fixed cells using the Dye Drop method
Authors: Mills Caitlin , Subramanian Kartik , Hafner Marc , Niepel Mario , Gerosa Luca , Chung Mirra , Victor Chiara , Gaudio Benjamin , Yapp Clarence , Nirmal Ajit Johnson , Clark Nicholas , Sorger Peter 
Published: July 2022

Abstract
High-throughput measurement of cells perturbed using libraries of small molecules, gene knockouts, or different microenvironmental factors is a key step in functional genomics and pre-clinical drug discovery. However, it remains difficult to perform accurate single-cell assays in 384-well plates, limiting many studies to well-average measurements (e.g. CellTiter-Glo®). Here we describe a public domain “Dye Drop” method that uses sequential density displacement and microscopy to perform multi-step assays on living cells. We use Dye Drop cell viability and DNA replication assays followed by immunofluorescence imaging to collect single-cell dose-response data for 67 investigational and clinical-grade small molecules in 58 breast cancer cell lines. By separating the cytostatic and cytotoxic effects of drugs computationally, we uncover unexpected relationships between the two. Dye Drop is rapid, reproducible, customizable, and compatible with manual or automated laboratory equipment. Dye Drop improves the tradeoff between data content and cost, enabling the collection of information-rich perturbagen-response datasets.
Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles
Authors: Tsai Tzung-En , Lin Pei-Hsuan , Lian Pei-Fen , Li Chia-Jung , Vitale Salvatore Giovanni , Mikuš Mislav , Su Wan-Ping , Tsai Hsiao-Wen , Tsui Kuan-Hao , Lin Li-Te 
Published: July 2022

Abstract
Background Artificial oocyte activation (AOA) is used to improve fertilization rate following fertilization failure after intracytoplasmic sperm injection (ICSI). Several studies have also shown that AOA may be involved in embryo development. Women with poor ovarian response are more likely to encounter in vitro fertilization (IVF) failure due to poor embryo quality. The aim of this study was to investigate whether AOA could improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles.Methods The retrospective cohort study consisted of 308 patients who fulfilled the POSEIDON Group 4 criteria and received IVF-ICSI cycles. The study group included 91 patients receiving AOA with calcium ionophores following ICSI. A total of 168 patients in the control group underwent ICSI without AOA. The baseline and cycle characteristics and embryo quality were compared between the two groups.Results At baseline, there were more IVF attempts, greater primary infertility, higher basal FSH levels and lower anti-Müllerian hormone (AMH) levels in the AOA group than in the non-AOA group. In terms of embryo quality, there were higher cleavage rates and top-quality Day 3 embryo (TQE) rates, as well as higher percentages of more than 1 TQE and TQE rates ≥ 50 in the AOA group than in the non-AOA group. The multivariate analysis revealed that AOA was positively associated with more than 1 TQE (adjusted OR 3.24, 95% CI 1.63–6.45, P = 0.001) and a TQE rate ≥ 50 (adjusted OR 2.14, 95% CI 1.20–3.80, P = 0.010). When the study population was divided into 2 subgroups based on the age of 40 years old, the beneficial effects of AOA on embryo quality were only observed in the subgroup of age ≥ 40 years old. Conclusions Our data suggest that AOA with calcium ionophores may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles, especially in women aged ≥ 40 years.
Prognostic Factors among Patients with Brain Metastases from Cancer of Unknown Primary
Authors: Padilla C. S. , Ho V. K. Y. , Strate I. H. , Leenders W. P. J. , Vos F. Y. F. L , Zanten S. E. M Veldhuijzen van , Loef C. 
Published: July 2022

Abstract
Background
Cancer of an unknown primary (CUP) has a dismal prognosis, the situation is worse for CUP patients with brain metastases (BM-CUP). This study aimed provides better insight into BM-CUP occurrence and determinants of patients’ survival in a population-based setting.
Methods
Cases were selected from the Netherlands Cancer Registry (1,430 BM-CUP/17,140 CUP). Baseline characteristics between CUP patients with and without BM were tested using chi-square tests and Mann-Whitney U tests. Patients’ overall survival (OS) curves were estimated by the Kaplan-Meier method, and prognostic factors on OS was assessed using Cox proportional hazards regression analyses.
Results
The proportion of BM-CUP patients among CUP increased from 8% in 2009–2010 to 10% in 2017–2018 (p < 0.001). Most patients presented with multiple brain lesions (53%). Survival of BM-CUP improved over time: one-year OS increased from 10% for patients diagnosed in 2009–2010 to 17% (2017–2018) (p < 0.01), and median survival times increased from 1.8 months to 2.4 months. Aside from time period and elderly age, independent predictors of poor survival were multiple (HR 1.25; p < 0.01) or unknown (HR 1.48; p < 0.01) locations of BM, unknown/poorly/undifferentiated carcinoma histology (HR 1.53; p < 0.01), or clinical symptoms of BM (HR 1.74; p < 0.01), accompanying liver metastasis (HR 1.43; p < 0.01) and more than one metastatic site outside the brain compared to none (HR 1.52; p < 0.01).
Conclusion
This research contributes to better knowledge on BM-CUP patients. Comprehensive baseline information aids the implementation and evaluation of new diagnostic approaches, treatment protocols and supportive/palliative care guidelines thus improve patients’ quality of life.
Biodegradable Mg-Zn-Ca-Y glass forming alloy with an amendment in mechanical properties and corrosion resistance
Authors: Ramya M. 
Published: July 2022

Abstract
For orthopedic application, the biodegradable implant material should possess a combination of good mechanical strength, reasonable ductility and optimal corrosion resistance. The key challenge in developing magnesium (Mg) based metallic glasses as viable orthopedic implant is to improve its mechanical properties as well as its corrosion resistance. In this work, an attempt has been made to improve the mechanical behavior and corrosion resistance of Mg-Zn-Ca glass forming alloy using yttrium (Y) addition. Mg66Zn30Ca4 metallic glass and a novel Mg-Zn-Ca-Y glass forming alloy with nominal composition of Mg52.5Zn40.5Ca5Y2 were synthesized. The effect of Y addition on the glass forming ability, mechanical behavior and corrosion properties of Mg-Zn-Ca metallic glass was investigated using X-ray diffraction, differential scanning calorimetry, hardness tests, compressive tests and electrochemical studies. Mg66Zn30Ca4 was completely amorphous while the glass forming ability reduced with Y addition. Enhancement in mechanical properties and corrosion resistance were observed upon addition of Y. Enrichment of mechanical behavior and corrosion resistance in Mg52.5Zn40.5Ca5Y2 alloy was attributed to the presence of Mg12YZn LPSO and Mg3YZn6 icosahedral phases formed due to the addition of Y.
Intraoperative Sequential Evaluation of the Rotational Stability of a Cementless Stem in Total Hip Arthroplasty—A Preliminary Study
Authors: Kinoshita Sakae , Kinoshita Koichi , Sakamoto Tetsuya , Seo Hajime , Suzuki Masahiro , Yamamoto Takuaki 
Published: July 2022

Abstract
Background: In cementless total hip arthroplasty (THA), the rotational stability of the stem is generally confirmed in a one-time manual evaluation by the surgeon. This study evaluates the intraoperative sequential changes of rotational stability using a torque wrench.Methods: Primary THA was performed on 65 consecutive hips. The stem design was a single-wedge for 52 hips and metaphyseal-filling for 13 hips. Intraoperative evaluation of rotational stability was uniformly performed using a torque wrench to prevent individual surgeons’ variances. The evaluation was performed immediately after insertion of the broach and before stem insertion.Results: Immediately after insertion of the broach, rotational stability was confirmed using a torque wrench in all cases, which was maintained for 17 of 52 (33%) single-wedge broaches and 4 of 13 (31%) metaphyseal-filling broaches before stem insertion. Among the hips showing instability, 11 of 35 (31%) single-wedge broaches and 6 of 9 (67%) metaphyseal filling broaches were upsized; the remaining hips were stabilized through deeper insertion. Conclusions: Rotational stability achieved immediately after the insertion of the broach was not necessarily maintained during surgery.
Biodiversity–stability relationships strengthen over time in a long-term grassland experiment
Authors: Wagg Cameron , Roscher Christiane , Weigelt Alexandra , Vogel Anja , Ebeling Anne , de Luca Enrica , Roeder Anna , Kleinspehn Clemens , Temperton Vicky , Marquard Elisabeth , Meyer Sebastian , Scherer-Lorenzen Michael , Buchmann Nina , Fischer Markus , Weisser Wolfgang , Eisenhauer Nico , Schmid Bernhard 
Published: July 2022

Abstract
Numerous studies have demonstrated that biodiversity drives ecosystem functioning, yet there is a lack of knowledge about how biodiversity loss alters ecosystems functioning and stability in the long-term. We report on temporal changes in the species richness–productivity, –stability, –species asynchrony, and –complementarity relationships over 17 years in a grassland biodiversity experiment. Richness–productivity and richness–complementarity relationships strengthened because productivity declined more rapidly in less than in more diverse communities. Using five-year rolling windows, we found that richness–stability relationships became stronger over time because more diverse communities maintained greater productivity. In later years asynchrony increased temporal complementarity among species, thus providing an insurance effect of species richness on stability. These results show how mechanisms stabilizing ecosystem functioning can change with community age. They demonstrate the importance of preserving diversity in natural systems as the role of diversity for ecosystem stability may take decades to realize the full potential.
Evaluating the Impact of Land Use/Land Cover Changes on the Surface Urban Heat Island intensity: The case study of Kabul city, Afghanistan
Authors: Sahak Ahmad Shakib , Hotaki M. Sulaiman Fayez , Ahmadi Karimullah , Karsli Fevzi 
Published: July 2022

Abstract
The purpose of this paper is to detect the areas which are affected by urban heat island (UHI) based on the relationship between land surface temperature and land use /land cover (LU/LC) changes during 1998, 2011, and 2020 for the major city of Kabul, the capital of Afghanistan, using multispectral and multi-temporal Landsat data (TM and OLI/TIRS). To achieve the objectives, the emissivity corrected land surface temperature method was examined to calculate Land Surface Temperature (LST), and the Land-use/Land-cover map was prepared using the support vector machine (SVM) supervised algorithm. The LU/LC was categorized into five major classes (vegetation, water-body, built-up, bare-land, and soil). According to the LST map estimated by processing the thermal band of the satellite image, areas influenced by Urban Heat Island (UHI) were detected to evaluate their anomalies to the existing LU/LC types. The findings of LST illustrate, that the mean recorded LST in 1998 was 39.42˚C, whereas the mean recorded LST in 2020 was 41.25˚C, which demonstrates a 1.83 ˚C increase for the whole study period. Specifically in 1998 only five districts (1,16,9,15, and 19) were affected by surface UHIs, while in 2011, the surface UHIs influenced areas increased to eight districts (15, 16, 1, 21, 17, 12, 13, and 8), and in 2020, the surface UHIs affected regions are improved to ten districts (1,19, 15,16, 9,17, 22, 11, 13, and 2) over the Kabul City. These variations and improvements are mostly due to the status of LU/LC in the study area, and it demonstrates the strong link between land cover and land surface temperature. Furthermore, Normalized difference vegetation index (NDVI), and normalized difference built-up index (NDBI) were also extracted. The relationship of NDVI and NDBI with LST was evaluated. Based on the results, a strong negative relationship between LST and NDVI was observed, while a positive relationship between LST and NDBI was recorded. The findings of this work show that an increase in non-evaporation areas and a decline in the greenery surfaces increased the LST. Consequently, the outcomes of this study are significant for decision-makers and urban planners to manage the drawbacks of urbanization temperature in arid and semi-arid areas.
Prevention of unplanned extubation in PICU Nurse-led quality improvement project
Authors: Obina Hazel Lyn , Tayag Kathyrine , Almohileb Hammad , Alomani Hakem 
Published: July 2022

Abstract
Introduction:Unplanned extubation is a recognized health problem and frequent morbidity in PICU.Method:Our SMART aim is to reduce the UPE rate to less than 1 per 100 ventilator days and sustain it for at least six months within 12 months. We chose the rate of UPE as an outcome measure. We chose Percentage of PICU staff who attended UPE training, Percentage of compliance to nurse assignment based on RAS, percentage of adherence to safety tag, Percentage of adherence to ETT fixation and completion of UPE case analysis form as process measures. We used PDSA as the main strategy to test the changes and implement multiple interventions.Result: Over 32 months of the entire project period, we recorded 10 UPEs events. 80% of patients were one year old or less. 60% of UPEs were with uncuffed ETT, and 80% happened in the early morning between 00:00 and 12:00. 50% needed reintubation, and 80% were discharged. However, 20% died in PICU (2 patients). 3 PDSAs were rolled out during the project and the rate of UPE decreased from 0.4 per 100 ventilation days in the year 2019 to 0.1 per 100 ventilation days in the year 2021 and was sustained for more than six months.Conclusion:UPE is significant morbidity and mortality in PICU, and we can identify the high-risk patients and the factors that contribute to such. Nurse-led QIP resulted in an apparent decrease in UPEs rate in PICU.
Documenting Parents’ Intervention Choices for their Autistic Children in Ireland
Authors: Liston Kate , Gunning Ciara , Harkry Lisa 
Published: July 2022

Abstract
Documenting parents’ decision-making regarding intervention for their autistic children and the factors that influence their choices is important. Understanding which interventions are most commonly selected, factors that influence these choices, and reasons for discontinuing or not selecting an intervention are vital to enable professionals to provide support for parents making these decisions. Using an online survey, Irish parents (n = 124) of autistic children reported the interventions they had chosen or had not chosen to engage in with their children, as well as factors that influenced their selection. Results indicated that parents in Ireland engage in a variety of interventions with their autistic children to support development across domains. Analysis of results indicated factors influencing decision making and engagement.
Diagnosing Silicosis Using Adaptive Neuro-Fuzzy Inference System
Authors: Eravcı Deniz Boz , Rouyendegh) Babek Erdebilli (B.D 
Published: July 2022

Abstract
Early diagnosis of disease such as Silicosis generally increases the chances for successful treatment by focusing on detecting symptomatic patients as early as possible. Early diagnosis is important for life-saving. In this study, we use an Adaptive Neuro-Fuzzy Inference System to evaluate the possibility of silica exposure leading to silicosis. The aim of this study presents Diagnosing Silicosis with ANFIS to develop proactive and predictible methods for occupational health and safety in workplace. Experimental results for the model reveal that the model successfully forecast Silicosis and an accuracy rate of 94%. Correlation Between Real Risk and Predicted Risk is detected 0,981. There is calculated the statistically significant strong and positive relationship between real outputs and ANFIS predicted outputs at the level of α = 0,05 (r=0,981;p<0,001).ANFIS provides an alternative and proactive method for diagnosing Silicosis. ANFIS can be a useful tool for occupational health and safety professionals and researchers for early diagnosis saving life.
A Study of Fine Needle Aspiration Cytology of Breast Lump With The Use of National Health Service Breast Screening Program (NHSBSP) - Study Of 500 Cases
Authors: Shahu Neha Shivkanth , Gamit Bhavna Nilesh , Sheth Sheetal Pankajbhai , Sutariya Sweta Ashokbhai , Kukadiya Harshal Harsukhbhai 
Published: July 2022

Background: FNAC is rapid, simple, safe, cost effective and good screening procedure with high sensitivity and specificity. Clinically, the diseases of breast mainly present as palpable breast lump, pain and nipple discharge. Most of the breast lumps are benign but pose a significant anxiety to the patient, which can be allayed by giving assurance that, usually it is benign. So it is necessary to distinguish benign from malignant conditions
Methods: The present study on was carried out during June 2017 to May 2019. We categorized the patients into C1 (Inadequate), C2 (Benign), C3 (Atypia, probably benign), C4 (Suspicious of malignancy) and C5 (Malignant) category according to NHSBSP and correlated histopathologically whenever available.
Result: Total 500 cases examined. Majority of the cases were in the 3rd decade of the life. Benign category comprised of 368 cases (73.6%), followed by malignant disease 61 (12.2%). Fibroadenoma was most common comprising of 230 cases (62.3%) among benign cases. Out of 230 cases of Fibroadenoma, most (89) cases were in 21-30 years age group, followed by 11-20 years age group. Breast carcinoma was most common (31.1%) in 41-50 years age group and 61-70 (27.9%) years age group followed by 51-60 (19.7%) years age group.
Conclusion: FNAC of breast lesions is advantageous for both clinicians and patients because of its immediate results, economy, and accuracy. FNAC has got significant diagnostic value in differentiating benign from malignant lesions providing us valuable information for planning of subsequent therapeutic management and avoiding unwanted surgeries.