bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of an Inexpensive Short-Term, Theoretical-Practical Course on Videosurgery for Training Surgeons
Authors: Takegawa Paula Haveroth , Kalil Jefferson , Bustorff-Silva Joaquim , Miranda Márcio Lopes 
Published: March 2022

Abstract
Introduction: The rapid development of video surgery and minimally invasive surgical techniques prompted many studies on the methods of teaching these techniques to young surgeons in training. However, the characteristics of a short-term course that is both easily accessible and efficient for this group of surgeons remain controversial. To investigate this issue, a short-term training method was proposed for first year surgery residents, using inexpensive handmade wooden simulation boxes with the students smartphones as cameras . Its effectiveness was evaluated, as well as possible factors that could influence student performance, such as gender and previous experience with video games. Methods: 36 first-year General Surgery residents, entering in 2019 and 2020, participated in the study: 21 were males and 15 were females with ages between 22 and 29 years old, (mean 25.47 years). All participants performed a pre-established exercise (placing two simple stitches using a laparoscopic simulator), which was timed and scored. They then participated in a short theoretical-practical course, consisting of an initial lecture followed by 4 exercises on handcrafted wooden laparoscopic video surgery simulators. Afterwards, they were asked to repeat the same exercise from the first step. Finally, they answered a questionnaire that included questions on previous videogame experience. The data were tabulated and submitted to statistical analysis.Results: In the pre-training exercise, 15 (41.66%) participants were able to perform the two simple stitches in the simulator box within the maximum time limit of 5 minutes. After the short course, 22 (61.11%) of participants were able to perform the complete exercise. Improvement in the time to complete the practical exercise was statistically significant (p=0.0296) after participating in the theoretical-practical course. A better pre- and post-training performance was demonstrated by the 17 participants with experience with video games (p=0.0116), and a better post-training performance was demonstrated by female participants (p=0.0405). Conclusion: This short-term inexpensive theoretical-practical course in laparoscopic training for surgeons in training was effective in reducing the execution time of a laparoscopic stitch in a simulation box. Previous experience with video games and/or female gender appear to be associated with improved performance.
In silico prediction, Characterization, Docking studies and Molecular dynamics simulation of human p97 in complex with p37 cofactor
Authors: Mirzadeh Abolfazl , Kobakhidze George , Vuillemot Rémi , Jonic Slavica , Rouiller Isabelle 
Published: March 2022

Abstract
Background
The AAA + ATPase p97 is an essential unfoldase/segragase involved in a multitude of cellular processes. It functions as a molecular machine critical for protein homeostasis, homotypic membrane fusion events and organelle biogenesis during mitosis in which it acts in concert with cofactors p47 and p37. Cofactors assist p97 in extracting and unfolding protein substrates through its ATP hydrolysis. In contrast to p97ʼs cofactors, p37 uniquely increases the ATPase activity of p97. Disease-causing mutations in p97, including mutations that cause neurodegenerative diseases, increase cofactor association with its N-domain, ATPase activity and improper substrate processing. Upregulation of p97 has also been observed in various cancers. This study was aimed towards the characterization of the protein-protein interaction between p97 and p37 at the atomic level. It defined the interacting residues in p97 and p37. The knowledge will facilitate the design of unique small molecules inhibiting this interaction with insights into cancer therapy and drug design.
Results
The homology model of human p37 UBX domain was built from the X-ray crystal structure of p47 C-terminus from rat (1S3S, G) as a template and assessed by model validation analysis. According to the HDOCK, HAWKDOCK, MM-GBSA binding free energy calculations and Arpeggio, we found that there are several hydrophobic and two hydrogen-bonding interactions between p37 UBX and p97 N-D1 domain. In addition, Residues p37 UBX predicted to be involved in the interactions with p97 N-D1 domain interface are highly conserved among UBX cofactors.
Conclusion
This study provides a reliable structural insight into the p37-p97 complex binding sites at the atomic level though molecular docking coupled with molecular dynamics simulation. This can guide the rational design of small molecule drugs for inhibiting mutant p97 activity.
A qualitative exploration of the enablers and barriers to the provision of outpatient clinics by hospital pharmacists.
Authors: Bailey Gerald , Dunlop Emma , Forsyth Paul 
Published: March 2022

Abstract
Background: With increasing demands on the National Health Service (NHS), Scottish Government-led pharmacy strategy has prioritised the development and expansion of modern outpatient services. Pharmacist-led outpatient clinics have been shown to reduce hospital admissions and improve patient outcomes. However, expanding these contemporary models of care has proved challenging, and there are few qualitative data about the factors affecting the provision of these.Aim: This study aimed to explore the enablers and barriers to hospital pharmacists providing outpatient clinics within the largest health authority in Scotland, NHS Greater Glasgow & Clyde (NHSGGC). Method: Between August and October 2020, one-to-one semi-structured interviews were conducted virtually using the videoconferencing platform Microsoft Teams®, with NHSGGC hospital pharmacists. Audio- and video-recordings of the interviews were transcribed in verbatim and underwent thematic analysis.Results: 16 hospital pharmacists were interviewed; 50% were clinic providers and 50% were not. Analysis generated seven themes: clinical or service need, individual psychological factors, clinic structure and processes, additional clinical skills and training, competing priorities, macro-level pharmacy working, and external stakeholder relationships.Conclusion: The enablers and barriers to hospital pharmacists providing outpatient clinics are multifaceted. Changes are required at the micro- and macro-level, with distributed leadership and system transformation remaining crucial. The forthcoming implementation of new professional curricula, should reconfirm whose role it is to develop such services and may enable pharmacists to overcome the individual and systematic barriers that prevent them from currently progressing the development of modern outpatient services; prospective research needs to accompany this vision.
Radiofrequency Echographic Multispectrometry (Rems): An Innovative Technique For The Assessment Of Bone Status In Young Women With Anorexia Nervosa
Authors: Caffarelli Carla , refaie Antonella Al , De Vita Michela , Pitinca Maria Dea Tomai , Goracci Arianna , Fagiolini Andrea , Gonnelli Stefano 
Published: March 2022

Abstract
Purpose Reduced bone mineral density (BMD) and increase risk of fragility fracture are common complication of anorexia nervosa (AN). BMD by Dual-energy X-ray Absorptiometry (DXA) present several limits in subjects with AN. This study aimed to evaluate the usefulness of the new Radiofrequency Echographic Multi Spectrometry (REMS) technique in the assessment of bone status in young women with AN. Methods In a cohort of 50 subjects with restrictive AN and in 30 healthy controls we measured BMD at the lumbar spine (LS-BMD), at femoral neck (FN-BMD) and total hip (TH-BMD) by using both DXA and REMS technique.Results BMD evaluated by DXA and REMS technique at all measurement sites were all significantly (p<0.01) lower in subjects suffering from AN subjects than in controls. Good correlations were detected between BMD by DXA and BMD by REMS measurements at LS (r=0.64, p<0.01) at FN (r=0.86, p<0.01) and at TH (r=0.84, p<0.01) in subjects suffering from AN. Moreover, Bland-Altman analysis confirmed the good agreement between the two techniques. The subjects suffering from AN with previous vertebral fragility fractures presented lower values of both BMD-LS and BMD-TH by DXA and by REMS with respect to those without fractures; however, the difference was significant only for BMD-TH by REMS (p<0.05). Conclusions Our data suggest that REMS technique due to its characteristic of precision and reproducibility may represent an important tool for the evaluation of the changes in bone status in AN young women, especially during the fertile age and in case of pregnancy and breastfeeding. Level of Evidence Level III cohort study
Effect of Gamma Irradiation Combined with Certain Entomopathogenic Fungi on some Biological Aspects of Galleria mellonella
Authors: Mohamed Hussein Farid , El-Naggar Samira Elsayed Mustafa , Sweilem Mahmoud Abd El-Mohsen , Ibrahim Adly Mohamed , El-khawaga Ola Elsayed  Abd Alrahman 
Published: March 2022

Abstract
Background: the prevailing research become analyzing the impact of the one-of-a-kind doses of gamma irradiation (70,100,125 and 150 Gy) one after the other or mixed with the LC50 of certain entomopathogenic fungi (Beauveria bassiana, Paecilomyces lilacinus) on selected biological aspects of the greater wax moth, Galleria mellonella (larval–pupal period, The percentage pupation, The percentage adult emergence, sex ratio and The percentage adult survival) many of the first generations (F1) of G. mellonella. Results: The joint treatment of Gamma irradiation and LC50 of Beauveria bassiana and Paecilomyces lilacinus increased the larval - pupal periods, while, pupation, adult emergence, survival percentage and the sex ratio were reduced in the combined treatments more than each treatment alone. Conclusions: The second instar larvae of Galleria mellonella descending of the irradiated parental male or female pupae with 70,100 and 125 Gy then treated with the LC50 of Beauveria bassiana and Paecilomyces lilacinus adversely affected on the different biological aspects. The combined treatment was greater than either, in the case of fungal or irradiation treatment alone.
Adolescence Obesity Risk Increases with Increased Screen Time: A Systematic Review and Dose-Response Meta-Analysis
Authors: Abbasalizad-Farhangi Mahdieh , Jahangiry Leila 
Published: March 2022

Abstract
Background: Adolescence is a critical time period in human life. Adolescence is associated with reduced physical activity and increased sedentary behaviors. In the current systematic review and dose-response meta-analysis, we evaluated the association between screen time and obesity risk among adolescents. Methods: A systematic search from PubMed, Embase and Scopus electronic databases through September 2021 was performed. Studies that evaluated the association between screen time and obesity among adolescents up to September 2021 were retrieved. A total of 64 qualified studies were included into meta-analysis. Results: The results of the two-class meta-analysis showed that adolescents at the highest category of screen time were 1.4 times more likely to develop obesity (OR=1.393; CI=1.264, 1.536; P <0.001). The results of subgrouping identified that continent was the possible heterogeneity source. No evidence of non-linear association between increased screen time and obesity risk among adolescents was observed (P-nonlinearity= 0.278). Conclusion: For the first time, the current systematic review and meta-analysis revealed a positive association between screen time and obesity among adolescents without any dose-response evidence.Registration: The protocol of the current work has been registered in the PROSPERO system (Registration number: CRD42021233899).
Evaluation of the Retina, Choroid and Optic Disc Vascular Structures In Individuals With a History of Covid-19
Authors: Gedik Birumut , Yuksel Ozdemır , Erol Muhammet Kazim , Duman Fulya , Dogan Berna , Suren Elcin , Yavuz Sibel 
Published: March 2022

Abstract
IntroductionIn this study, we aimed to detect changes in posterior segment structures and posterior segment vascular density caused by COVID-19 using the optical coherence tomography angiography (OCTA) device.Material and MethodThe study included 20 eyes of 20 patients without any systemic or eye disease, who were followed up at the Ophthalmology Clinic of Health Sciences University Antalya Training and Research Hospital. The OCTA images of these individuals taken before COVID-19 and at six months after recovery were examined.ResultsThe mean choriocapillaris blood flow value of the patients was 2.00 ± 0.13 mm2 before COVID-19 and 2.08 ± 0.23 mm2 after the disease, the mean subfoveal choroidal thickness value was 247.33 ± 7.65 μm before the disease and 273.08 ± 4.92 μm after the disease, indicating a statistically significant difference (p = 0.003, p = 0.001, respectively). The mean retinal nerve fiber layer values before and after COVID-19 were 119.33 ± 3.88 and 117.50 ± 3.92 μm, respectively, and there was a statistically significant decrease (p < 0.001). ConclusionThis is the first study in the literature to evaluate the post-COVID-19 changes in the eye vascular structures ​​compared to the pre-disease values. We consider that inflammation and increased vascular permeability are effective in changes.
LED Nonlinearity Mitigation in a NOMA-OFDM VLC System Using a Union
of Precoder and Companding
Authors: Sharan Nishant , Ghorai Swapan Kumar , Kumar Ajit 
Published: March 2022

Abstract
The power domain non-orthogonal multiple access (NOMA) has been considered as an outstanding candidate for 5G visible light communication networks. Due to the various salient features like robustness to multi-path fading, low latency, high compatibility with multiple input multiple output (MIMO) systems, etc. orthogonal frequency division multiplexing access (OFDM) is foreseen to exist in 5G systems. NOMA-based optical OFDM (O-OFDM) is expected to be a promising candidate for supporting high rate internet connectivity, especially for
green indoor mobile networks. The OFDM waveform suffers from high PAPR issue. The high PAPR degrades the BER and also enhances the nonlinearity in an O-OFDM system. In this paper, a hybrid technique using a blend of precoder with compander is implemented to reduce the PAPR of NOMA based DC-biased O-OFDM (DCO-OFDM) system. The proposed NOMA DCO-OFDM system exhibits a low PAPR of only 4.3 dB. Also, for a reference bit error rate of 10^-4, the proposed technique displays an error vector magnitude (EVM) of 13.2 dB.
Functional Cotton Fiber-Based TLC-SERS Matrix for Rapid and Sensitive Detection of Mixed Dyes
Authors: Yao Huifang , Dong Xiaxiao , Xiong Hong , Zhou Ji , Ye Yong 
Published: March 2022

Abstract
A facile cotton fabric with a built-in TLC-SERS structure was fabricated to demonstrate an integrated TLC separation and SERS identification of mixed dyes. The soft and flexible SERS fabric was firstly fabricated using a simple method in which gold nanoparticles were in-situ synthesized on cotton fabrics by heating. β-CD was then grafted onto cotton fabric through crosslinking with citric acid in presence of sodium hypophosphite monohydrate via esterification reaction. The adsorption and TLC development performance of β-CD grafted fabrics were comprehensively investigated with two representative organic dyes, one anionic dye and one nonionic dye. Besides, the recyclable adsorption and separation performance were tested to evaluate its sustainable application prospects. It displayed less adsorption capacity loss and reusable separation performance after several cycles than the pristine cotton fabrics. Finally, two sets of mixed dyes were successfully separated on the TLC fabrics and then identified via on-site SERS according to their different migration distance. The developed TLC-SERS fabric shows the advantage of quick, easy to handle, low-cost, sensitive, and could be exploited in on-site study of synthetic dyes in art objects, textile and packaging products or forensic applications.
Associations Between Paraben In Human Serum And Rheumatoid Arthritis Risks
Authors: Zhao Yun , Qu Jianli , Zhao Meirong , Wu Pengfei , Xue Jing , jin hangbiao 
Published: March 2022

Abstract
Parabens are widely used in consumer products resulting in frequent exposure to humans and some toxic effects in humans. However, little is known about the association between human paraben exposure and rheumatoid arthritis (RA). In this study, a case-control cohort (n = 290) were established in Hangzhou, China, aiming to quantify the residues of MeP, EtP, PrP, and BuP in serum samples and to determine their associations with RA risks. MeP (mean 4.7 ng/mL, < LOD–20 ng/mL) was the predominant paraben in human serum, followed by PrP (1.9 ng/mL, < LOD–24 ng/mL), EtP (1.4 ng/mL, < LOD–10 ng/mL), and BuP (1.09 ng/mL, < LOD–10 ng/mL). Human serum concentrations of MeP were correlated with the levels of rheumatoid factors [adjusted β = 0.19, 95% confidence interval (CI): 0.12, 0.46], anti-cyclic citrullinated peptide antibody (adjusted β = 0.30, 95% CI: 0.26, 0.58), immunoglobulin G (adjusted β = 0.24, 95% CI: 0.21, 0.30). Significant associations between MeP (adjusted β = 0.15, 95% CI: 0.037, 0.28) and PrP (adjusted β = 0.23, 95% CI: 0.080, 0.38) exposure were correlated with C-reactive protein levels. In addtion, a correlation between MeP and odds ratios (OR) of RA (ORcrude = 1.337, CI: 1.110, 1.624, p = 0.03; ORadjusted = 1.866, CI: 1.321, 2.636, p = 0.02) was positive and significant. To our knowledge, this study first finds the significant associations among parabens exposure, change of specific immune marker, and RA risks, indicating that human exposure to parabens may increase the risk of RA.
How depression and sleep quality are associated with state-trait anxiety in medical school undergraduates in Anhui Province, China: A mediation analysis
Authors: Chen Jiangyun , Tuersun Yusupujiang , Yang Jiao , Xiong Man , Wang Yueying , Rao Xinyi , Jiang Shuai 
Published: March 2022

Abstract
Background: To investigate the relationship between depression and sleep quality and state-trait anxiety among undergraduate students in medical colleges and universities in Anhui Province, to enhance the attention to the mental health of undergraduate students in medical colleges and universities, and to provide a basis for mental health intervention strategies for undergraduate students in medical colleges and universities. Methods: The Pittsburgh Sleep Quality Index, State-Trait Anxiety Inventory, and Depression Self-Rating Scale were used to investigate 1300 college students in four medical undergraduate colleges and universities in Anhui Province. Results: The Pittsburgh Sleep Quality Index score was (5.87+2.944), the State-Trait Anxiety Inventory score was (84.10+17.276), and the Depression Self-Rating Scale score was (49.04+10.845). Depression status and Pittsburgh Sleep Quality Index were positively correlated (r=0.381, p<0.001), and Pittsburgh Sleep Quality Index and State-Trait Anxiety were positively correlated (r=0.428, p<0.001). Conclusions: Taking four undergraduate medical colleges and universities in Anhui Province as an example, sleep quality of college students in medical colleges and universities was positively correlated with depressive state, sleep quality and state-trait anxiety were positively correlated, and sleep quality was influencing depressive state through state-trait anxiety.
Impact of COVID-19 RT-PCR Testing of Asymptomatic Health Care Workers on Absenteeism and Hospital Transmission During the Pandemic
Authors: Mendes Elisa Teixeira , Neto Danilo Glauco Pereira Villagelin , Ferreira Giulia Magalhães , Valença Ian Nunes , Lima Maria Patelli Juliani Souza , Freitas Maria Fernanda Marciano Barros , Donalisio Maria Rita , Melo Marcio Cristiano , Lazari Carolina , Goes Jacqueline , Morales Ingra , Jardim Ana Carolina Gomes , Santos Pamela Andrade dos , Franco Lucas Augusto Moyses , Sabino Ester Cerdeiro , Costa Silvia Figueiredo 
Published: March 2022

Abstract
Reducing the transmission of SARS-CoV-2 from asymptomatic and pre-symptomatic patients is critical in controlling the circulation of the virus. This study evaluated the prevalence of RT-PCR positivity in serial tests (every 20 days) in 429 asymptomatic health care workers (HCW) and its impact on absenteeism from May to August 2020. Asymptomatic HCW from a COVID-19 reference hospital in Campinas (1.2 million inhabitants), Brazil, were tested, screened, and placed on leave. A time-series segmented regression of weekly absenteeism rates was used, and cases of infection among hospitalized patients were analyzed. Viral gene sequencing and phylogenetic analysis were performed on samples gathered from professionals who had a positive result. A significant decrease in absenteeism was detected 3–4 weeks after the intervention at a time of increased transmission within the city. The prevalence of RT-PCR positivity among asymptomatic professionals was 17.3%. Phylogenetic analyses of 59 samples detected nine clusters, two of them strongly suggestive of intra-hospital transmission with strains (75% B.1.1.28) circulating in the region during this period.Testing and placing asymptomatic professionals on leave contributed to control strategy for COVID-19 transmission in the hospital environment, and in reducing positivity and absenteeism, which directly influences the quality of care and exposes professionals to an extra load of stress.
Psychological distress and resilience in patients with advanced cancer during the Covid-19 pandemic: the mediating role of spirituality
Authors: Mihic-Góngora Luka , Jiménez-Fonseca Paula , Hernández Raquel , Gil-Raga Mireia , Pacheco-Barcia Vilma , Manzano-Fernández Aranzazu , Hernando-Polo Susana , Antoñanzas-Basa Monica , Corral Maria J. , Valero-Arbizu María , Calderon Caterina 
Published: March 2022

Abstract
Background. The purpose of this study was to investigate the sociodemographic factors related to psychological distress, spirituality, and resilience, and to examine the mediating role of spirituality with respect to psychological distress and resilience in patients with advanced, unresectable cancer during the Covid-19 pandemic.Methods. A prospective, cross-sectional design was adopted. Data were collected from 636 participants with advanced cancer at 15 tertiary hospitals in Spain between February 2019 and December 2021. Participants completed self-report measures: Brief Resilient Coping Scale (BRCS), Brief Symptom Inventory (BSI-18), and Spiritual well‐being (FACIT-Sp). Hierarchical linear regression models were used to explore the mediating role of spirituality. Results. Spirituality was significantly different according to the person’s age and marital status. Psychological distress accounted for 12% of the variance in resilience (β =-0.32, p<0.001) and spirituality, another 15% (β =0.48, p<0.001). Spirituality acted as a partial mediator in the relationship between psychological distress and resilience in individuals with advanced cancer.Conclusions. Both psychological distress and spirituality played a role in resilience in cases of advanced cancer. Spirituality can help promote subjective well-being and increased resilience in these subjects.