bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of depression on the association between colder indoor temperature and higher blood pressure
Authors: Okumura Kazuki , Obayashi Kenji , Tai Yoshiaki , Yamagami Yuki , Kurumatani Norio , Saeki Keigo 
Published: September 2022

Objectives:
Cold exposure accounts for more than 7% of all-cause mortality worldwide, and cold-induced blood pressure (BP) elevation and consequent cardiovascular events are partially responsible. For prevention, it is important to identify risk factors for exaggerated temperature-sensitivity of BP but this is not fully understood. This study investigated whether depressive symptoms affect the relationship between indoor temperature and BP.

Methods:
We conducted a cross-sectional analysis of 1076 community-based individuals who were at least 60 years of age. Depressive symptoms were assessed using the 15-item Geriatric Depression Scale at a cutoff point of 4/5. We performed ambulatory BP monitoring and indoor temperature measurement on two consecutive days during the cold season in Nara, Japan.

Results:
When using daytime SBP as a dependent variable, multilevel linear regression analyses showed that lower daytime indoor temperature was significantly associated with higher daytime SBP in the depressive group (n = 216, β = −0.804, P < 0.001) but not in the nondepressive group (n = 860, β = −0.173, P = 0.120); moreover, a significant interaction between depression and daytime indoor temperature was observed (P = 0.014). These relationships were independent of potential confounders including age, gender, BMI, medications, and physical activity. Similar results were obtained for morning SBP, nocturnal SBP dipping, and morning BP surge.

Conclusion:
The results suggest that depressive participants are more likely to have cold-induced BP elevation than nondepressive participants. Further longitudinal studies are warranted to determine whether people with depressive symptoms are at a high risk for cold-related cardiovascular events.
Changes Over Time in COVID-19 Incidence, Vaccinations, Serum Spike IgG, and Viral Neutralizing Potential Among Individuals From a North American Gaming Venue
Authors: Wisnewski Adam V. , Cantley Linda , Campillo Luna Julian , Liu Jian , Smith Richard F. , Hager Kelly , Redlich Carrie A. 
Published: September 2022

Objective
This study aims to evaluate COVID-19 cases and vaccine responses among workers in the gaming/entertainment industry.

Methods
Participants provided detailed information on occupational risk factors, demographics, COVID-19 history, and vaccination status through questionnaire. Enzyme-linked immunosorbent assays were used to measure serum antiviral antibodies and neutralizing capacity.

Results
Five hundred-fifty individuals participated with n = 228 (41.5%) returning for follow-up. At least 71% of participants were fully vaccinated within 8 months of vaccine availability and COVID-19 rates declined concomitantly. Serum anti–spike IgG levels and neutralizing capacity were significantly (P < 0.001) associated COVID-19 history and vaccine type, but not occupational risk factors, and declined (on average 36%) within 5 months. Few vaccine nonresponders (n = 12) and “breakthrough” infections (n = 1) were noted.

Conclusions
COVID-19 vaccination was associated with a marked decrease in infections; however, individual humoral responses varied and declined significantly over time.
Deciphering SARS CoV-2-associated pathways from RNA sequencing data of COVID-19-infected A549 cells and potential therapeutics using in silico methods
Authors: Natesan Pushparaj Peter , Damiati Laila Abdullah , Denetiu Iuliana , Bakhashab Sherin , Asif Muhammad , Hussain Abrar , Ahmed Sagheer , Hamdard Mohammad Hamid , Rasool Mahmood 
Published: September 2022

Background:
Coronavirus (CoV) disease (COVID-19) identified in Wuhan, China, in 2019, is mainly characterized by atypical pneumonia and severe acute respiratory syndrome (SARS) and is caused by SARS CoV-2, which belongs to the Coronaviridae family. Determining the underlying disease mechanisms is central to the identification and development of COVID-19-specific drugs for effective treatment and prevention of human-to-human transmission, disease complications, and deaths.

Methods:
Here, next-generation RNA sequencing (RNA Seq) data were obtained using Illumina Next Seq 500 from SARS CoV-infected A549 cells and mock-treated A549 cells from the Gene Expression Omnibus (GEO) (GSE147507), and quality control (QC) was assessed before RNA Seq analysis using CLC Genomics Workbench 20.0. Differentially expressed genes (DEGs) were imported into BioJupies to decipher COVID-19 induced signaling pathways and small molecules derived from chemical synthesis or natural sources to mimic or reverse COVID -19 specific gene signatures. In addition, iPathwayGuide was used to identify COVID-19-specific signaling pathways, as well as drugs and natural products with anti-COVID-19 potential.

Results:
Here, we identified the potential activation of upstream regulators such as signal transducer and activator of transcription 2 (STAT2), interferon regulatory factor 9 (IRF9), and interferon beta (IFNβ), interleukin-1 beta (IL-1β), and interferon regulatory factor 3 (IRF3). COVID-19 infection activated key infectious disease-specific immune-related signaling pathways such as influenza A, viral protein interaction with cytokine and cytokine receptors, measles, Epstein-Barr virus infection, and IL-17 signaling pathway. Besides, we identified drugs such as prednisolone, methylprednisolone, diclofenac, compound JQ1, and natural products such as Withaferin-A and JinFuKang as candidates for further experimental validation of COVID-19 therapy.

Conclusions:
In conclusion, we have used the in silico next-generation knowledge discovery (NGKD) methods to discover COVID-19-associated pathways and specific therapeutics that have the potential to ameliorate the disease pathologies associated with COVID-19.
: Short-term effects of exposure to particulate matter on hospital admissions for asthma and chronic obstructive pulmonary disease
Authors: Han Chang Hoon , Pak Haeyong , Lee Jung Mo , Chung Jae Ho 
Published: September 2022

We investigated the effects of particulate matter (PM) factors on hospitalization rates for asthma and chronic obstructive pulmonary disease (COPD).
We obtained data on pollutants—PM10, PM2.5—in Seoul, South Korea. We also investigated data for asthma and COPD exacerbation that required hospitalization from 2006 to 2016. We used a time-stratified case-crossover design and generalized additive models with log transformation to assess adjusted risk, and conditional logistic regression was performed to analyze these data.
Our study showed that PM10 and PM2.5, on different best lag days, were associated with increased risks of COPD or asthma hospitalization. The odds ratios (ORs) for each per-unit increase in PM10 and PM2.5 were higher in patients with male asthma (PM10: OR, 1.012; 95% confidence interval [CI], 1.008–1.016 and PM2.5: OR, 1.015; 95% CI, 1008–1.023), preschool asthma (PM10: OR, 1.015; 95% CI, 1.006–1.015 and PM2.5: OR, 1.015; 95% CI, 1.009–1.024), male COPD (PM10: OR, 1.012; 95% CI, 1.005–1.019 and PM2.5: OR, 1.013; 95% CI, 1.000–1.026), and senior COPD (PM10: OR, 1.016; 95% CI, 1.008–1.024 and PM2.5: OR, 1.022; 95% CI, 1.007–1.036).
Increasing PM levels increased hospitalizations for asthma and COPD. Additionally, the consequences may be different according to age and sex, and PM2.5 may have a more significant effect on airway disease patients than PM10.
Comparative study between thulium laser and cold knife visual urethrotomy for treatment of short bulbomembranous urethral stricture
Authors: Rehan Mohamed , Elnady Esam A. , Khater Saed , Elsayed Ahmed Fawzi Arafat , Abdel Gawad Ahmed M. , Freeg Mohamed Abdel Hafeez Aly , Mahmoud Alaa R. 
Published: September 2022

Introduction:
The classical way to treat urethral stricture is the direct vision cold knife internal urethrotomy (DVIU). Along with advances in laser technology, laser urethrotomy is widely used, such as neodymium-doped yttrium aluminum garnet, argon, potassium titanyl phosphate, and thulium laser. We aimed to compare thulium laser urethrotomy (TLU) and cold knife visual urethrotomy (CKVU) in terms of short bulbomembranous urethral stricture management.

Materials and methods:
This prospective interventional study was conducted for 24 months, from January 2018 to January 2020, on 60 patients with primary short bulbo-membranous urethral stricture who came to the Department of Urology of Al-Azhar University Hospital, New Damietta, Egypt. We divided these patients into 2 age-matched groups; 30 patients treated with CKVU and 30 patients with TLU.

Results:
Regarding efficacy, postvoid residual urine volume (PVR) was reduced significantly in both groups (P < .001) after 6 months of follow-up; however, the reduction in TLU was greater than CKVU (P = .008). The improvement of Qmax after 6 months was significant and comparable in both groups. Regarding the quality of life, both groups showed a significant (<0.05) improvement in international prostate symptom score (IPSS) and the Male Sexual Health Questionnaire (MSHQ) scale, without no significant difference between both groups (>0.05). TLU showed a significantly (P = .038) shorter operative duration (24 ± 4.17 min) than CKVU duration (33 ± 4.86 min). Compared with CKVU, TLU was associated with less blood loss during surgery (P = .001), lower recurrence rate (46.7% vs. 19.97%, respectively), and lower frequencies of urethral dilatation (P = .001).

Conclusion:
TLU is an effective and safe therapy for managing bulbomembranous urethral strictures, with a relatively low recurrence rate. Further investigations of other techniques are recommended to look for the most appropriate procedure to combat the urethral stricture problem.
ERAS® protocol improves survival after radical cystectomy: A single-center cohort study
Authors: Crettenand François , M’Baya Olivier , Grilo Nuno , Valerio Massimo , Dartiguenave Florence , Cerantola Yannick , Roth Beat , Rouvé Jean-Daniel , Blanc Catherine , Lucca Ilaria 
Published: September 2022

Introduction:
To evaluate Enhanced recovery after surgery (ERAS®) protocol on oncological outcomes for patients treated with radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB).

Methods:
A prospectively maintained single-institutional database comprising 160 consecutive UCB patients who underwent open RC from 2012 to 2020 was analyzed. Patients receiving chemotherapy and those with a urinary diversion other than ileal conduit were excluded. Patients were divided into two groups according to the perioperative management (ERAS® and pre-ERAS®). The study aimed to evaluate the impact of the ERAS® protocol on survival at five years after surgery using a Kaplan–Meier log-rank test. A multivariable Cox proportional hazards model was used to identify prognostic factors for cancer-specific (CSS) and overall survival (OS).

Results:
Of the 107 patients considered for the final analysis, 74 (69%) were included in the ERAS® group. Median follow-up for patients alive at last follow-up was 28 months (interquartile range [IQR] 12–48). Five-years CSS rate was 74% for ERAS® patients, compared to 48% for the control population (P = 0.02), while 5-years OS was 31% higher in the ERAS® (67% vs. 36%, P = .003). In the multivariable analysis, ERAS® protocol and tumor stage were independent factors of CSS, while ERAS®, tumor stage so as total blood loss were independent factors for OS.

Discussion:
A dedicated ERAS® protocol for UCB patients treated with RC has a significant impact on survival. Reduction of stress after a major surgery and its potential improvement of perioperative patient’s immunity may explain these data.
Comparative Study of Application of Computed Tomography/Ultrasound and Computed Tomography Imaging Guidance Methods in the Microwave Ablation of Liver Cancer
Authors: Liang Junhua , Zhang Songnan , Han Zhezhu , Li Ying , Sun Honghua , Kim Yongmin , Kim Tiefeng 
Published: September 2022

Purpose
The aim of the study is to assess the clinical value of the combined computed tomography (CT)/ultrasound (US) guidance in microwave ablation (MWA) for hepatocellular carcinoma (HCC).

Methods
From July 16, 2016, to June 20, 2021, medical records of 150 HCC patients treated with MWA were retrospectively analyzed. Ninety-two patients with 115 liver tumors underwent MWA under combined CT/US guidance, and 58 patients with 73 liver tumors received MWA under CT guidance alone. The clinical efficacy of combined CT/US-guided MWA was analyzed. We compared the complications, procedure time, and CT scan times between the 2 groups.

Results
The total complete ablation rate and complete ablation rate of high-risk location tumors were significantly higher in the group treated with combined CT/US guidance (P = 0.0471 and P = 0.0347, respectively), the imaging guidance modality (odds ratio, 0.303; 95% confidence interval [CI], 0.095–0.970; P = 0.044) was an independent factor for ablation efficacy. These 2 groups also had significant differences in the procedure time (P = 0.0171), the incidence rate of pneumothorax (P = 0.0209), abdominal pain (P = 0.0196), nausea or vomiting (P = 0.0026), and intraoperative CT scan times (P < 0.001). The overall complication rates (P = 0.4023) and recurrence rates (P = 0.5063) between the 2 groups were not statistically significant. However, CT/US group has a better short-term progressive free survival (log-rank P = 0.103, Breslow P = 0.030). In multivariate analysis, guidance modality (hazard ratio, 0.586; 95% CI, 0.368–0.934; P = 0.025) and Barcelona Clinic Liver Cancer stage (hazard ratio, 2.933; 95% CI, 1.678–5.127; P < 0.001) were risk factor for progressive free survival.

Conclusions
Percutaneous MWA under the combined CT/US guidance for HCC can improve clinical benefits.
High-Risk Features of Esophageal Adenocarcinoma Following Neoadjuvant Chemoradiation
Authors: Bayley Erin M. , Ivy Megan L. , Shewale Jitesh B. , Ge Phillip S. , Antonoff Mara B. , Francis Ashleigh M. , Hofstetter Wayne L. , Mehran Reza J. , Rajaram Ravi , Rice David C. , Roth Jack A. , Sepesi Boris , Vaporciyan Ara A. , Walsh Garrett L. , Lee J. Jack , Louie Brian E. , Swisher Stephen G. 
Published: September 2022

Objective:
Clinical predictors of pathological complete response have not reliably identified patients for whom an organ-sparing approach following neoadjuvant chemoradiation be undertaken for esophageal cancer patients. We sought to identify high-risk predictors of residual carcinoma that may preclude patients from a selective surgical approach.

Background:
Patients treated with neoadjuvant chemoradiation followed by esophagectomy for esophageal adenocarcinoma were identified.

Patients and Methods:
Correlation between clinical and pathologic complete responses were examined. Regression models and recursive partitioning were utilized to identify features associated with residual carcinoma. External validation of these high-risk factors was performed on a data set from an independent institution.

Results:
A total of 326 patients were identified, in whom clinical complete response was noted in 104/326 (32%). Pathologic complete response was noted in only 33/104 (32%) of these clinical complete responders. Multivariable analysis identified that the presence of stricture (P=0.011), positive biopsy (P=0.010), and signet ring cell histology (P=0.019) were associated with residual cancer. Recursive partitioning corroborated a 94% probability of residual disease, or greater, for each of these features. The positive predictive value was >90% for these characteristics. A SUVmax >5.4 at the esophageal primary in the absence of esophagitis was also a high-risk factor for residual carcinoma. External validation confirmed these high-risk factors to be implicated in the finding of residual carcinoma.

Conclusions:
Clinical parameters of response are poor predictors of complete pathologic response leading to challenges in selecting candidates for active surveillance. However, we characterize several high-risk features for residual carcinoma which indicate that esophagectomy should not be delayed.
An Alternative Approach to Tablet Splitting and Grinding for Medication Administration
Authors: Taneja Rajneesh , Scarim Joseph , Pande Poonam G , Scarim Anthony , Nahata Milap C , Jew Rita K , Inabathina Koteswara 
Published: September 2022

AbstractPurposeTablet formulations fail to meet the needs of patients unable to swallow tablets such as pediatric, elderly, and patients that must receive medications via feeding tubes. Our aim was to develop and test a new, simple device (XTEMP-R™) and the methodology for converting tablets into a homogeneous suspension for medication administration.MethodsWe developed a new device comprised of a flexible receptacle, a tight-fitting cap, and a suction cup bottom to convert tablets into liquid preparations. TB treatment drugs, TBAJ-876 and TBI-223, were dispersed within the device utilizing water and commonly available suspending vehicles. We investigated the effectiveness of the XTEMP-R device in dispersing tablets. This was accomplished by visual observations, determining the fineness of dispersion, and measuring the total drug recovery from the dispersions in XTEMP-R. We investigated the accuracy and reproducibility of delivering aliquots from these suspensions by determining the dose reproducibility upon suspension and upon redispersion after 24 hours. The effectiveness of the device was also evaluated using commercially available tablets of acetaminophen, amlodipine, glimepiride, metformin and valsartan.ResultsThe suspensions were visually uniform without any large particles. The suspensions passed through #18 sieve confirming that the particles were less than 1000 μm. Average total dose recovery of three suspensions each was determined to be 101.3% and 99.2% for TBI-223 and TBAJ-876, respectively. Reproducibility from aliquots of 2 mL each were 98.9-99.7% for three replicates of TBI-223 suspensions, and 102.6-103.2% for TBAJ-876 suspensions. Aliquots tested after 24 hours confirmed uniform re-dispersibility.ConclusionWe have demonstrated that XTEMP-R can be utilized to prepare homogeneous suspensions can be prepared conveniently and efficiently in less than 10 minutes without any drug loss. Aliquots for partial dose delivery can be withdrawn accurately. These findings demonstrate that XTEMP-R can be used to accurately deliver doses of suspensions for patients who cannot swallow tablets.
Organizational impact of an ID NOW™ COVID-19 point-of-care testing for SARS-CoV2 detection in a maternity ward
Authors: Van Jean-Claude Nguyen , Pilmis Benoît , Khaterchi Amir , Billuart Olivier , De Ponfilly Gauthier Péan , Monnier Alban Le , Azria Elie , Mizrahi Assaf 
Published: September 2022

AbstractBackgroundSARS-CoV-2 has been responsible for more than 550 million cases of COVID-19 worldwide. RT-PCR is considered the “gold standard” for the diagnosis of patients suspected of having COVID-19. During the heightened waves of the pandemic, more rapid tests have been required. Point-of-care tests (POCT) for COVID-19 include antigen tests, serological tests, and other molecular-based platforms. The ID NOW™ COVID-19 assay (Abbott) performs an isothermal gene amplification of a target encoding the RNA-dependent RNA polymerase of SARSCoV-2. The main objective of this study was to evaluate the organizational impact following the implementation of a POC testing platform ID NOW™ in a maternity ward.Materials and MethodsThis retrospective study included pregnant women admitted for Groupe Hospitalier Paris Saint-Joseph Paris. The study was conducted over 2 periods lasting 6 months each. The first period (P1) corresponded to the 2nd wave in France (July to December 2020) whereas the second (P2) period focused on the 3rd wave (February to July 2021). During P1, viral detection was performed by RT-PCR at the hospital’s laboratory. During P2, it was performed with the ID NOW™ COVID-19 test directly in the delivery room by nursing staff after training and certification. Our primary endpoint was the length of time in the birth room from admission to discharge in the postpartum period.Results2447 pregnant women were included, 1053 during P1 and 1394 during P2. The median age, percentage of singleton pregnancies, mean gestational age, percentage of nulliparous individuals, percentage of vaginal deliveries, and COVID19 positivity rate were comparable between the two periods. During P2, the length of stay in the delivery room was significantly shorter than during P1 (17.9 vs 14.7 hours, p<0.001).ConclusionAnalysis of the data from this study following the implementation of the ID NOW™ POCT in the maternity ward indicates a significant decrease in the length of stay in the birth room. This outcome needs to be confirmed in a multicenter cohort, in particular to precise the specific impact of COVID-19 care on delays.
Deep immune profiling uncovers novel associations with clinical phenotypes of Multisystem Inflammatory Syndrome in Children (MIS-C)
Authors: Redmond Christopher , Kitakule Moses M. , Son Aran , Sylvester McKella , Sacco Keith , Delmonte Ottavia , Licciardi Francesco , Castagnoli Riccardo , Poli Cecilia , Espinoza Yasmin , Astudillo Camila , Weber Sarah E. , Montealegre Sanchez Gina A. , Barron Karyl , Magliocco Mary , Dobbs Kerry , Zhang Yu , Matthews Helen , Oguz Cihan , Su Helen C. , Notarangelo Luigi D. , Frischmeyer-Guerrerio Pamela A. , Schwartz Daniella M. 
Published: September 2022

AbstractMultisystem Inflammatory Syndrome in Children (MIS-C) is a systemic inflammatory condition that follows SARS-CoV2 infection or exposure in children. Clinical presentations are highly variable and include fever, gastrointestinal (GI) disease, shock, and Kawasaki Disease-like illness (MIS-C/KD). Compared to patients with acute COVID, patients with MIS-C have a distinct immune signature and expansion of TRVB11 expressing T cells. However, the relationship between immunological and clinical phenotypes of MIS-C is unknown. Here, we measured serum biomarkers, TCR repertoire, and SARS-CoV2-specific T cell responses in a cohort of 76 MIS-C patients. Serum biomarkers associated with macrophage and Th1 activation were elevated in patients with shock, consistent with previous reports. Significantly increased SARS-CoV-2-induced IFN-γ, IL-2, and TNF-α production were seen in CD4+ T cells from patients with neurologic involvement and respiratory failure. Diarrhea was associated with a significant reduction in shock-associated serum biomarkers, suggesting a protective effect. TRVB11 usage was highly associated with MIS-C/KD and coronary aneurysms, suggesting a potential biomarker for these manifestations in MIS-C patients. By identifying novel immunologic associations with the different clinical phenotypes of MIS-C, this study provides insights into the clinical heterogeneity of MIS-C. These unique immunophenotypic associations could provide biomarkers to identify patients at risk for severe complications of MIS-C, including shock and MIS-C/KD.