bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Synthesis of New Bithiophene Based Planar AIE Red Light Emitters: A Detailed Theoretical and Experimental Analysis**
Authors: Mohan Makesh , Nagarajan Satyanarayan M. , Trivedi Darshak R. 
Published: March 2022

AbstractBithiophene core with −CN substituted pyrazole and imidazole side chains yieldingB1,B2, andB3have been designed and synthesized viz Schiff's base condensation reaction. Molecules, at their solid‐state exhibited red‐light emission supporting AIE mechanism. The series exhibited the highest relative quantum yield of value 18.66 % byB1with the lowest recorded forB3exhibiting 2.4 %. DFT results reveal the synthesized molecules at their optimized ground state adopt a planar structure. Theoretical calculation further validates the molecules to adopt a slip‐stacking type of molecular packing arrangement at its condensed state, conducive for AIE. A large π‐π stacking distance between the lattice plane of 3.4 Å, 3.6 Å and 3.5 Å possessed byB1,B2, andB3respectively, favors AIE. Computational calculation on electron and hole reorganization energy reveals the effective role of two −CN groups in altering the hole mobility in comparison with the other molecules in the series.
Enhanced Photocatalytic Properties of Surfactants Modified ZnO Particles Synthesized Directly via Sonochemistry Technique
Authors: Cai Mei , Shui Anze , Wang Yu , Xiong Hao , Zeng Shenghui , He Chao , Qian Junjie , Du Bin 
Published: March 2022

AbstractThe preparation of ZnO with outstanding photocatalytic performance by a simple method without doping the second phase is a challenge. Herein, an environmental, friendly, simple, and quick route is proposed to synthesize the surfactant modified ZnO nanoparticles using different surfactants as the photocatalyst. Introducing the sodium dodecyl sulfate (SDS), an anionic surfactant, increases surface hydroxyl groups, enhances visible light absorption intensity, reduces oxygen defects and decreases recombination rate of photo‐generated electron/hole pairs, which significantly improves the photocatalytic properties in degradation of the rhodamine B (RhB) under visible‐light. In particular, the 6 % SDS surfactant modified ZnO samples demonstrates the excellent photodegradation performance, enabling photodegradation of RhB within 15 minutes. This work provides a new route to synthesize photocatalytic materials with excellent photodegradation performance.
Observations with gPhone Gravimeter in Moscow
Authors: Chistiakova Ekaterina 
Published: March 2022

AbstractLong-term recordings of temporal gravity variations were made with the gPhoneX # 117 spring gravimeter at the Center of Geodesy, Cartography and SDI (TsNIIGAiK). The purpose of the observations is to obtain reliable parameters of the Earth tides and non-tidal component for a site located within the territory of Moscow. At a later stage, these parameters will be used to process absolute gravity observations. One year of recordings were chosen (April 1, 2016–March 03, 2017). Preliminary data processing is fully automated and runs in a program written in Python. In the course of the research, the parameters of the instrument drift were determined by the method of piecewise linear approximation of the observations. The estimated parameters of the Earth tides were obtained according to the algorithms of the ETERNA 3.4 program (Wenzel, Bulletin d’Informations des Marées Terrestres 124:9425–9439, 1996). The non-tidal gravity changes (the difference between the experimental and local model data) were compared with the model of temporal variations of the gravity field caused by atmospheric loading. Theoretical values were provided by EOST Loading Service.The studies presented here, are unique for Moscow site and they are one of the first attempts to use high-precision recordings of spring gravimeters while computing observed tidal and non-tidal parameters.
Drug interaction alerts in older primary care patients, and related medically justified actions
Authors: Tukukino Carina , Parodi López Naldy , Svensson Staffan A. , Wallerstedt Susanna M. 
Published: March 2022

Abstract
Purpose
To describe presented interaction alerts in older patients, and the extent to which these require further medical action for the specific patient or are already being addressed.

Methods
Interaction alerts presented at a physician consultation, for 274 consecutive primary care patients treated with two or more drugs (median age: 75 years; 59% female), were extracted. These alerts are based on Janusmed, a decision support integrated in the medical records that provides recommendations for managing the interactions. One general practitioner (GP) and one GP/clinical pharmacologist determined in retrospect, first independently and then in consensus, whether the alerts justified further medical action, considering each patient’s health condition.

Results
In all, 405 drug interaction alerts in 151 (55%) patients were triggered. Medical action in response was deemed medically justified for 35 (9%) alerts in 26 (17%) patients. These actions most often involved a switch to a less interacting drug from the same drug class (n = 10), a separate intake (n = 9), or the ordering of a laboratory test (n = 8). Out of 531 actions suggested by the alert system, only 38 (7%) were applicable to the specific patient, as, for instance, laboratory parameters were already being satisfactorily monitored or a separate intake implemented.

Conclusions
More than every other older patient receives drug treatment that triggers drug interaction alerts. Nine in ten alerts were already being addressed or were not relevant in the clinical setting, whereas, for the remaining tenth, some medical action, that for unknown reasons had not been taken, was reasonable. These findings show that interaction alerts are questionable as indicators of problematic prescribing.
P2Y12-dependent activation of hematopoietic stem and progenitor cells promotes emergency hematopoiesis after myocardial infarction
Authors: Seung Hana , Wrobel Jan , Wadle Carolin , Bühler Timon , Chiang Diana , Rettkowski Jasmin , Cabezas-Wallscheid Nina , Hechler Béatrice , Stachon Peter , Maier Alexander , Weber Christian , Wolf Dennis , Duerschmied Daniel , Idzko Marco , Bode Christoph , von zur Mühlen Constantin , Hilgendorf Ingo , Heidt Timo 
Published: March 2022

AbstractEmergency hematopoiesis is the driving force of the inflammatory response to myocardial infarction (MI). Increased proliferation of hematopoietic stem and progenitor cells (LSK) after MI enhances cell production in the bone marrow (BM) and replenishes leukocyte supply for local cell recruitment to the infarct. Decoding the regulation of the inflammatory cascade after MI may provide new avenues to improve post-MI remodeling. In this study, we describe the influence of adenosine diphosphate (ADP)-dependent P2Y12-mediated signaling on emergency hematopoiesis and cardiac remodeling after MI. Permanent coronary ligation was performed to induce MI in a murine model. BM activation, inflammatory cell composition and cardiac function were assessed using global and platelet-specific gene knockout and pharmacological inhibition models for P2Y12. Complementary in vitro studies allowed for investigation of ADP-dependent effects on LSK cells. We found that ADP acts as a danger signal for the hematopoietic BM and fosters emergency hematopoiesis by promoting Akt phosphorylation and cell cycle progression. We were able to detect P2Y12 in LSK, implicating a direct effect of ADP on LSK via P2Y12 signaling. P2Y12 knockout and P2Y12 inhibitor treatment with prasugrel reduced emergency hematopoiesis and the excessive inflammatory response to MI, translating to lower numbers of downstream progeny and inflammatory cells in the blood and infarct. Ultimately, P2Y12 inhibition preserved cardiac function and reduced chronic adverse cardiac remodeling after MI. P2Y12-dependent signaling is involved in emergency hematopoiesis after MI and fuels post-ischemic inflammation, proposing a novel, non-canonical value for P2Y12 antagonists beyond inhibition of platelet-mediated atherothrombosis.
Neuroimmune disorders in COVID-19
Authors: Ariño Helena , Heartshorne Rosie , Michael Benedict D. , Nicholson Timothy R. , Vincent Angela , Pollak Thomas A. , Vogrig Alberto 
Published: March 2022

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the aetiologic agent of the coronavirus disease 2019 (COVID-19), is now rapidly disseminating throughout the world with 147,443,848 cases reported so far. Around 30–80% of cases (depending on COVID-19 severity) are reported to have neurological manifestations including anosmia, stroke, and encephalopathy. In addition, some patients have recognised autoimmune neurological disorders, including both central (limbic and brainstem encephalitis, acute disseminated encephalomyelitis [ADEM], and myelitis) and peripheral diseases (Guillain–Barré and Miller Fisher syndrome). We systematically describe data from 133 reported series on the Neurology and Neuropsychiatry of COVID-19 blog (https://blogs.bmj.com/jnnp/2020/05/01/the-neurology-and-neuropsychiatry-of-covid-19/) providing a comprehensive overview concerning the diagnosis, and treatment of patients with neurological immune-mediated complications of SARS-CoV-2. In most cases the latency to neurological disorder was highly variable and the immunological or other mechanisms involved were unclear. Despite specific neuronal or ganglioside antibodies only being identified in 10, many had apparent responses to immunotherapies. Although the proportion of patients experiencing immune-mediated neurological disorders is small, the total number is likely to be underestimated. The early recognition and improvement seen with use of immunomodulatory treatment, even in those without identified autoantibodies, makes delayed or missed diagnoses risk the potential for long-term disability, including the emerging challenge of post-acute COVID-19 sequelae (PACS). Finally, potential issues regarding the use of immunotherapies in patients with pre-existent neuro-immunological disorders are also discussed.
Machine learning versus logistic regression for prognostic modelling in individuals with non-specific neck pain
Authors: Liew Bernard X. W. , Kovacs Francisco M. , Rügamer David , Royuela Ana 
Published: March 2022

AbstractPurposePrognostic models play an important clinical role in the clinical management of neck pain disorders. No study has compared the performance of modern machine learning (ML) techniques, against more traditional regression techniques, when developing prognostic models in individuals with neck pain.MethodsA total of 3001 participants suffering from neck pain were included into a clinical registry database. Three dichotomous outcomes of a clinically meaningful improvement in neck pain, arm pain, and disability at 3 months follow-up were used. There were 26 predictors included, five numeric and 21 categorical. Seven modelling techniques were used (logistic regression, least absolute shrinkage and selection operator [LASSO], gradient boosting [Xgboost], K nearest neighbours [KNN], support vector machine [SVM], random forest [RF], and artificial neural networks [ANN]). The primary measure of model performance was the area under the receiver operator curve (AUC) of the validation set.ResultsThe ML algorithm with the greatest AUC for predicting arm pain (AUC = 0.765), neck pain (AUC = 0.726), and disability (AUC = 0.703) was Xgboost. The improvement in classification AUC from stepwise logistic regression to the best performing machine learning algorithms was 0.081, 0.103, and 0.077 for predicting arm pain, neck pain, and disability, respectively.ConclusionThe improvement in prediction performance between ML and logistic regression methods in the present study, could be due to the potential greater nonlinearity between baseline predictors and clinical outcome. The benefit of machine learning in prognostic modelling may be dependent on factors like sample size, variable type, and disease investigated.
Generalized Estimator for Population Mean Using Auxiliary Attribute in Stratified Two-Phase Sampling
Authors: Rana Quratulain , Qureshi Muhammad Nouman , Hanif Muhammad 
Published: March 2022

AbstractIn sampling theory, the auxiliary information is widely used to increase precision of the estimators when the study variable is correlated with the auxiliary variable. In several practical situations, the auxiliary information is available in the form of the auxiliary attribute(s). In this paper, we proposed a generalized estimator for the estimation of finite population mean using the auxiliary attribute under stratified two-phase sampling. The mathematical expressions of approximate bias and mean square error (MSE) of the proposed estimator are obtained to the first-order. Many special cases of the proposed estimator are also obtained using the known parameters of the auxiliary attribute. The algebraic comparisons of the MSE of the proposed estimator have been made the MSE of the competing estimators. The performance of the proposed estimator is evaluated using real data-sets. The results illustrate the good performance of the proposed estimators and its sub-cases.
Using Multiple Pretreatment Periods to Improve Difference-in-Differences and Staggered Adoption Designs
Authors: Egami Naoki , Yamauchi Soichiro 
Published: March 2022

AbstractWhile a difference-in-differences (DID) design was originally developed with one pre- and one posttreatment period, data from additional pretreatment periods are often available. How can researchers improve the DID design with such multiple pretreatment periods under what conditions? We first use potential outcomes to clarify three benefits of multiple pretreatment periods: (1) assessing the parallel trends assumption, (2) improving estimation accuracy, and (3) allowing for a more flexible parallel trends assumption. We then propose a new estimator, double DID, which combines all the benefits through the generalized method of moments and contains the two-way fixed effects regression as a special case. We show that the double DID requires a weaker assumption about outcome trends and is more efficient than existing DID estimators. We also generalize the double DID to the staggered adoption design where different units can receive the treatment in different time periods. We illustrate the proposed method with two empirical applications, covering both the basic DID and staggered adoption designs. We offer an open-source R package that implements the proposed methodologies.
Measuring discrimination experienced by people with a mental illness: replication of the short-form DISCUS in six world regions
Authors: Brohan Elaine , Thornicroft Graham , Rüsch Nicolas , Lasalvia Antonio , Campbell Megan M. , Yalçınkaya-Alkar Özden , Lanfredi Mariangela , Ochoa Susana , Üçok Alp , Tomás Catarina , Fadipe Babatunde , Sebes Julia , Fiorillo Andrea , Sampogna Gaia , Paula Cristiane Silvestre , Valverde Leonidas , Schomerus Georg , Klemm Pia , Ouali Uta , Castelein Stynke , Alexová Aneta , Oexle Nathalie , Guimarães Patrícia Neves , Sportel Bouwina Esther , Chang Chih-Cheng , Li Jie , Shanthi Chilasagaram , Reneses Blanca , Bakolis Ioannis , Evans-Lacko Sara 
Published: March 2022

AbstractBackgroundThe Discrimination and Stigma Scale (DISC) is a patient-reported outcome measure which assesses experiences of discrimination among persons with a mental illness globally.MethodsThis study evaluated whether the psychometric properties of a short-form version, DISC-Ultra Short (DISCUS) (11-item), could be replicated in a sample of people with a wide range of mental disorders from 21 sites in 15 countries/territories, across six global regions. The frequency of experienced discrimination was reported. Scaling assumptions (confirmatory factor analysis, inter-item and item-total correlations), reliability (internal consistency) and validity (convergent validity, known groups method) were investigated in each region, and by diagnosis group.Results1195 people participated. The most frequently reported experiences of discrimination were being shunned or avoided at work (48.7%) and discrimination in making or keeping friends (47.2%). Confirmatory factor analysis supported a unidimensional model across all six regions and five diagnosis groups. Convergent validity was confirmed in the total sample and within all regions [ Internalised Stigma of Mental Illness (ISMI-10): 0.28–0.67, stopping self: 0.54–0.72, stigma consciousness: −0.32–0.57], as was internal consistency reliability (α = 0.74–0.84). Known groups validity was established in the global sample with levels of experienced discrimination significantly higher for those experiencing higher depression [Patient Health Questionnaire (PHQ)-2: p < 0.001], lower mental wellbeing [Warwick-Edinburgh Well-being Scale (WEMWBS): p < 0.001], higher suicidal ideation [Beck Hopelessness Scale (BHS)-4: p < 0.001] and higher risk of suicidal behaviour [Suicidal Ideation Attributes Scale (SIDAS): p < 0.001].ConclusionsThe DISCUS is a reliable and valid unidimensional measure of experienced discrimination for use in global settings with similar properties to the longer DISC. It offers a brief assessment of experienced discrimination for use in clinical and research settings.
Musical development then and now: in conversation with June Boyce-Tillman
Authors: Boyce-Tillman June , Anderson Anthony 
Published: March 2022

AbstractJune Boyce-Tillman and Keith Swanwick’s article on musical development is the second most widely cited paper in the history of the British Journal of Music Education. It appears in many discussions of musical development. A selection of the diverse domains where the paper is cited includes: instrumental teaching, Special Education Needs, primary school teaching, the development of learning for professional musicians, secondary school teaching, musicians’ skill development, adult music teaching and jazz improvisation. However, the background to this work, which was conceived for June Boyce-Tillman’s PhD thesis, is not always so well known. This article presents a research interview with June Boyce-Tillman conducted in August 2017. It explores her musical background and music education experiences, and seeks to enable further discussion of the characteristics which were described in the spiral model. The interview focuses on the concepts of Materials, vernacular, and musical Values, in particular, and the implications of these modes of understanding for classroom practices, including curriculum design.
Histological finding of maternal antibody-associated congenital heart block accompanied by large atrial septal defect and severe cardiac dysfunction
Authors: Endo Yasuhiro , Kawai Yoko , Yamagishi Masaaki 
Published: March 2022

AbstractCardiac dysfunction commonly occurs in congenital heart block associated with maternal anti-SSA antibodies, especially after pacemaker implantation. We report the case of a 4-year-old girl with antibody-associated congenital heart block and a large secundum atrial septal defect who presented with significant cardiac dysfunction 4 years after pacemaker implantation. Histological findings were useful for determining the course of treatment and perioperative risk of intracardiac repair.
TRIM46 activates AKT/HK2 signaling by modifying PHLPP2 ubiquitylation to promote glycolysis and chemoresistance of lung cancer cells
Authors: Tantai Jicheng , Pan Xufeng , Chen Yong , Shen Yuzhou , Ji Chunyu 
Published: March 2022

AbstractThe incidence of lung cancer is increasing worldwide. Although great progress in lung cancer treatment has been made, the clinical outcome is still unsatisfactory. Tripartite motif (TRIM)-containing proteins has been shown to be closely related to tumor progression. However, the function of TRIM46 in lung cancer is largely unknown. Here, TRIM46 amplification was found in lung adenocarcinoma (LUAD) tissues and TRIM46 amplification was significantly associated with a poor survival rate. Overexpression of wild type TRIM46 increased the proliferation of LUAD cells and glycolysis, promoted xenografts growth, and enhanced cisplatin (DDP) resistance of LUAD cells via increased ubiquitination of pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) and upregulation of p-AKT. In contrast, overexpression of RING-mutant TRIM46 did not show any effects, suggesting the function of TRIM46 was dependent on the E3 ligase activity. Furthermore, we found that TRIM46 promoted LUAD cell proliferation and DDP resistance by enhancing glycolysis. PHLPP2 overexpression reversed the effects of TRIM46 overexpression. Amplification of TRIM46 also promoted LUAD growth and enhanced its DDP resistance in a patient-derived xenograft (PDX) model. In conclusion, our data highlight the importance of TRIM46/PHLPP2/AKT signaling in lung cancer and provide new insights into therapeutic strategies for lung cancer.
Phase II trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemia
Authors: Anderson Rebecca , Miller Lance D. , Isom Scott , Chou Jeff W. , Pladna Kristin M. , Schramm Nathaniel J. , Ellis Leslie R. , Howard Dianna S. , Bhave Rupali R. , Manuel Megan , Dralle Sarah , Lyerly Susan , Powell Bayard L. , Pardee Timothy S. 
Published: March 2022

AbstractDevimistat is a TCA cycle inhibitor. A previously completed phase I study of devimistat in combination with cytarabine and mitoxantrone in patients with relapsed or refractory AML showed promising response rates. Here we report the results of a single arm phase II study (NCT02484391). The primary outcome of feasibility of maintenance devimistat following induction and consolidation with devimistat in combination with high dose cytarabine and mitoxantrone was not met, as maintenance devimistat was only administered in 2 of 21 responders. The secondary outcomes of response (CR + CRi) and median survival were 44% (21/48) and 5.9 months respectively. There were no unexpected toxicities observed. An unplanned, post-hoc analysis of the phase I and II datasets suggests a trend of a dose response in older but not younger patients. RNA sequencing data from patient samples reveals an age-related decline in mitochondrial gene sets. Devimistat impairs ATP synthesis and we find a correlation between mitochondrial membrane potential and sensitivity to chemotherapy. Devimistat also induces mitochondrial reactive oxygen species and turnover consistent with mitophagy. We find that pharmacological or genetic inhibition of mitochondrial fission or autophagy sensitizes cells to devimistat. These findings suggest that an age related decline in mitochondrial quality and autophagy may be associated with response to devimistat however this needs to be confirmed in larger cohorts with proper trial design.
Repetitive marsquakes in Martian upper mantle
Authors: Sun Weijia , Tkalčić Hrvoje 
Published: March 2022

AbstractMarsquakes excite seismic wavefield, allowing the Martian interior structures to be probed. However, the Martian seismic data recorded by InSight have a low signal-to-noise ratio, making the identification of marsquakes challenging. Here we use the Matched Filter technique and Benford’s Law to detect hitherto undetected events. Based on nine marsquake templates, we report 47 newly detected events, >90% of which are associated with the two high-quality events located beneath Cerberus Fossae. They occurred at all times of the Martian day, thus excluding the tidal modulation (e.g., Phobos) as their cause. We attribute the newly discovered, low-frequency, repetitive events to magma movement associated with volcanic activity in the upper mantle beneath Cerberus Fossae. The continuous seismicity suggests that Cerberus Fossae is seismically highly active and that the Martian mantle is mobile.