bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salvage Surgeries for Splanchnic Artery Aneurysms after Failed Endovascular Therapies: Cases Series
Authors: Lin Yi-Chun , Liao Tzu-Chi , Jeng Long-Bin , Yang Horng-Ren , Hsu Chung-Ho , Lin Wei-Ching , Wu Ching-Feng , Yeh Chun-Chieh 
Published: February 2022

Abstract
IntroductionEndovascular therapies are the first-line treatment for splanchnic aneurysms. However, after failed endovascular therapies or giant aneurysms with mass effects, appropriate management for splanchnic aneurysms remained inconclusive.MethodA retrospective review was performed for consecutive patients (from 2019 to 2021) who underwent salvage surgeries following failed endovascular therapies for splanchnic artery aneurysms. Salvage operations included total aneurysmectomy with end-to-end vascular reconstruction and partial aneurysmectomy with directly closing bleeders from the intraluminal space of the aneurysms.ResultFour patients received salvage surgeries for three false aneurysms of the celiac or superior mesenteric arteries and a true aneurysm of the common hepatic artery. The causes of failed endovascular therapies included coil migration, insufficient space for safely deploying the endovascular stent or persistent mass effect from the thrombosed giant aneurysm. Mean hospital stay was five days (range, 3-7 days), with 0% of morbidity and mortality rate and 100% of symptoms improvement. During the follow-up period (mean, 8.75 months; range, 4-15 months), one patient suffered a small residual asymptomatic celiac artery aneurysm (8 mm in diameter) and was treated conservatively due to underlying liver cirrhosis.ConclusionSurgical management is a feasible, effective, and safe alternative for splanchnic aneurysms undergoing failed endovascular therapies.
Stat-3 Signaling Role in an Experimental Model of Nephropathy Induced by Doxorubicin.
Authors: Santos Thabata , Pereira Gabriel , Perez Ricardo , Coutinho Anna , Pereira Halisson , Silva Debora , Lima Marcelo , Dias Fernando , Almeida Danilo , Pereira Rafael 
Published: February 2022

Abstract
Focal Segmental Glomerulosclerosis (FSGS) is one of the most frequent glomerulopathies, and is considered a public health problem worldwide. FSGS is characterized by glomerular loss mainly due to inflammation and collagen fibers deposition. STAT-3 is a transcription factor associated with cell differentiation, migration and proliferation. Its activation occurs in response to several growth factors and cytokines. In renal cells, STAT-3 has been related with disease progression. Considering this perspective, the present study evaluated the involvement of STAT-3 in an experimental model of FSGS induced by Doxorubicin (DOX). First, we described a novel FSGS model in Swiss mice that after DOX administration showed typical signs of kidney dysfunction like higher proteinuria. Since there were no studies of ADM nephropathy model in heterogeneous mice, we were the first to evaluate the model in this lineage. Control animals treated with STAT-3 inhibitor (STATTIC) presented lower levels of albumin/creatinine ratio, glycosuria e proteinuria while DOX-injected mice showed higher levels. After analyzing some molecules involved in the STAT-3 signaling pathway, it was observed that STAT-3 blockade decreased levels of STAT-3, IL-6 and IL-6R, which remained elevated in DOX-administrated mice. Moreover, we detected that SOCS-3 (a regulator of STAT family) was up-regulated only in STATTIC-treated mice. Finally, histopathological analyzes showed that DOX-treated group had a significant increase in a tubulointerstitial fibrosis and tubular necrosis, which were not identified in both control and STATTIC groups. Thus, our results indicate that STAT-3 can have an important role in experimental FSGS induced by DOX and further studies are encouraged.
Association of Serum Uric Acid and Blood Pressure: A Cross-Sectional Study in A Working Population in China
Authors: Qian Hang , Mei Aihua , Xu Hao , Chen Jishun , Zhou Xintao , Li Yunpeng , Min Xinwen , Yang Handong , Li Xiulou , Yang Jingning , Zhong Jixin , Jiang Xueqiang , Li Dongfeng , Chen Jun 
Published: February 2022

Abstract
Objective: The aim of this study was to evaluate the independent relationship between Serum uric acid (SUA) and blood pressure. Methods: A cross-sectional study was conducted based on a sample of 6035 employees (3605 males and 2430 females). Multivariable regression analysis was performed to identify the association between risk factors for metabolic disorders and hypertension. Results: The SUA levels were closely and independently related to hypertension even after adjusting for age, sex, lipids and glucose. Conclusions: We verified that uric acid was associated with hypertension independent of other metabolic risk factors and that the presence of other risk factors with uric acid had an additive effect on blood pressure.
Insensitive cation effect on single-atom Ni catalyst allows selective electrochemical conversion of captured CO2 in universal media
Authors: Kim Jae Hyung , Jang Hyunsung , Choi Woong , Yun Hyewon , Lee Eun Chong , Kim Dongjin , Kim Ji Won , Lee Si Young , Hwang Yun Jeong 
Published: February 2022

Abstract
The direct electroconversion of captured CO2 is attracting attention as an alternative to the current energy-demanding CO2 separation processes. In conventional capturing media, the reaction inevitably takes place in the presence of bulky ammonium, leading to steric hindrance and low CO selectivity. Here, for the first time, we present a single atom Ni catalyst (Ni–N/C) exhibits superior activity for the electroconversion of captured CO2, without the need for additives. In a CO2-captured monoethanolamine-based electrolyte, Ni–N/C achieves a notably high CO selectivity of 64.9% at −50 mA cm−2 integrated with a membrane electrode assembly. We also propose that Ni–N/C demonstrates weak cation sensitivity to the CO2 reduction reaction, maintaining high CO production activity in various capturing solutions, while Ag shows a gradual decrease depending on the bulkiness of the amine. These trends provide insights into selective catalyst design for the electroconversion of captured CO2 in universal media.
Prognostic Implications of the Predominant Histologic Subtype in Stage I Lung Adenocarcinoma: Lack of Association with Overall Survival Based on Multi-Aspect Survival Analyses
Authors: Lee Jong Hyuk , Kim Hyungjin , Park Chang Min , Jeon Yoon Kyung , Chung Doo Hyun , Kim Young Tae , Goo Jin Mo 
Published: February 2022

Abstract
We aimed to investigate the prognostic role of the predominant histologic subtype classification of lung adenocarcinoma in the era of the eighth-edition staging system. A total of 587 patients with stage I adenocarcinomas (lepidic, n=46; acinar/papillary, n=484; solid/micropapillary, n=57) were assessed. The prognostic value of this subtype classification for overall survival (OS) was investigated with three multivariable analyses adjusted for the eighth-edition clinical T category and radiologic nodule type: the adjusted log-rank test, multivariable Cox hazard regression, and multivariable mixture cure model to evaluate long-term and short-term prognostic associations separately. In the adjusted log-rank test for pairwise comparisons, no evidence was found for differences in OS among the subtype classifications (p>.05). The histologic subtype was not an independent prognostic factor in either the Cox regression analysis (hazard ratio [HR] of acinar/papillary subtypes: 3.03; 95% confidence intertval [CI]: 0.4-22.59; p=0.28; HR of solid/micropapillary subtypes: 2.78; 95% CI: 0.34-22.37; p=.34) or the mixture cure model (cure probability model; odds ratio: 1.06 [95% CI: 0.38-2.95; p=.91]; failure time distribution model; HR: 0.94 [95% CI: 0.36-2.44; p=.89]). The prognostic implication of the predominant histologic subtype classification is not clear for stage I lung adenocarcinoma in the eighth-edition staging system.
Complications and Owner Satisfaction Associated with Limb Amputation in Cats: 59 cases (2007-2017)
Authors: Wagner John R. , DeSandre-Robinson Dana M. , Moore George E. , Loughin Catherine A. , Simons Micha C. 
Published: February 2022

Abstract
Background:Limb amputation may be recommended in domestic cats following a severe injury or disease. The purpose of the study was to report the signalment, the complications, recovery outcome, owner satisfaction and expectations of domestic cats following limb amputation. Results:Medical records of 3 specialty hospitals were reviewed for cats that received a single limb amputation in a 10 year period (2007-2017). These cat owners were contacted, and 59 owners completed surveys, comprising the study population. The most common reasons for limb amputation were neoplasia (54.2%, 32/59), traumatic injury (40.7%, 24/59), bone or joint infection (3.4%, 2/59), and thromboembolism (1.7%, 1/59). Thirty-four cats (57.6%) had postoperative complications. Of the fifty-nine surveys, 52.5% reported minor complications and 5.1% reported major complications. There were no differences in postoperative complication rates for thoracic versus pelvic limb amputations. All owners reported either excellent (77.9%, 46/59), good (20.3% 12/59), or fair (1.7%, 1/59) satisfaction with the procedure. Based on their previous experiences, 84.7 % (50/59) of owners would elect limb amputation if medically warranted for another pet. The remaining 15.3% of owners which would not elect limb amputation again had experienced death of their pet with a median survival time of 183 days. Conclusion:Owners reported a positive satisfaction when considering complications, recovery outcome, and expectations. This study can be used by veterinarians to guide cat owners in the decision making process of limb amputation.
Construction and validation of an m6A RNA methylation regulator prognostic model for early-stage clear cell renal cell carcinoma
Authors: Zhang Yushi , Wang Zhan , Zhang Mingxin , Seery Samuel , Zheng Guoyang , Wang Wenda , Zhao Yang , Wang Xu 
Published: February 2022

Abstract
Background: N6-methyladenosine (m6A) is the most common type of RNA methylation and is thought to participate in various biological and pathological processes, specifically in the regulation of tumorigenesis and metastasis. However, the exact prognostic role of m6A methylation regulators in early-stage clear cell renal cell carcinoma (ccRCC) is currently unknown.Purposes: To construct a prognostic model consisting of m6A RNA methylation regulators in early stage ccRCC and assess the reliability of the signature by proteomics. Additionally, we also explored the relationship between the prognostic model and tumor infiltrating immune cells within the tumor microenvironment.Materials and methods: Gene mutation and RNA sequencing data of 19 m6A methylation regulators for early-stage ccRCC patients were extracted from The Cancer Genome Atlas (TCGA) database with the corresponding clinical information. Univariate and multivariate Cox regression analysis were applied to construct a prognostic model and the proteomic data was used to validate the result. The correlations with the prognostic model and tumor infiltrating immune cells were assessed using Spearman rank correlation analysis. Results: 192 early stage ccRCC gene mutation data as well as 261 RNA sequencing data with relative clinical data were extracted from the TCGA. The overall mutation frequency of the 19 m6A RNA methylation regulators was relatively low with 4.69%. The transcriptome data showed that 11 genes were differentially expressed between cancer tissues and relatively normal tissues. Survival analysis highlighted four specific genes as having a significant influence on overall survival. An established model with four genes demonstrated the best predictability for early-stage ccRCC. After integrating clinical characteristics into the multivariate analysis, the model remained effective at predicting ccRCC prognosis. Spearman rank analysis suggested several tumor infiltrating immune cells like dendric cells, CD4+ cells, CD8+ T cells and macrophages were significantly correlated with the model. Proteomic data analysis showed that all the genes used to construct the model were differentially expressed in paired ccRCC tissues. Conclusion: A novel m6A methylation regulators-based prognostic signature was established and validated using a proteomic approach. In addition, the model was significantly correlated with multiple infiltrating immune cells in tumor microenvironment.
Individual and food environment determinants of Mediterranean diet adherence among Lebanese adults: a cross-sectional study
Authors: Khoury Veronique El , Malakieh Roubina , Boumosleh Jocelyne Matar , Obeid Cecile , Jaalouk Doris 
Published: February 2022

Abstract
Background: Many studies revealed positive health impacts of the Mediterranean diet (MD) especially on metabolic disorders. Conversely, information about determinants of adherence to the MD are limited. This study aims to examine the individual and environmental determinants of MD adherence among adults in Lebanon. Methods: A cross-sectional study was carried out during July 2021 among a convenient sample of 326 Lebanese adults. Data from participants were collected via an online survey developed by study researchers, that is composed of 3 well-structured questionnaires: a) background questionnaire; b) Perceived Nutrition Environment Measures Survey in the Mediterranean Context (NEMS-P-MED), and c) 14-item Mediterranean Diet Adherence Screener (14-MEDAS). Results: Mean MD score in the total sample was 7.59±2.22, reflecting moderate-to-fair MD adherence. Older age and having a regular routine of physical activity emerged as significant independent determinants of better MD adherence. Equally, availability of whole wheat pasta, rice or flour and fish at home and perceived importance of availability of easy to cook foods at food stores showed significant positive association, while healthy food availability, and in- store characteristics had no association with MD adherence score. Conclusion: Future public health interventions aiming at promoting MD adherence among young adults in Lebanon shall take account of availability of healthy food at home alongside individual factors such as meal preparation skills and regular physical activity.
Serum RANKL, OPG and Vitamin D in children with systemic lupus erythematosus
Authors: Hao Sheng , Zhang Jing , Huang Bingxue , Feng Dan , Niu Xiaoling , Huang Wen-Yan 
Published: February 2022

Abstract
Indroduction: SLE is an autoimmune multisystem disease. Glucocorticoid is an irreplaceable medication for SLE. Glucocorticoid and inflammation impact bone remodeling by OPG/RANKL/RANK signal system, which could lead to osteoporosis. Our aim is to clarify the expression of RANKL/OPG in children with SLE, and to preliminarily explore the changes of bone metabolism related indexes in children with SLE. Methods: Serum RANKL and OPG of 40 children with SLE and healthy children were detected by ELISA, while 25(OH)VitD3 was detected routinely. Clinical data of children with SLE were recorded, including gender, age, height, weight, BMI, duration of the disease, accumulated dose of glucocorticoid, and correlation analysis was conducted with RANKL, OPG and 25(OH)VitD3. Results: Serum RANKL concentration in SLE group was significantly higher than health group (9.82±7.20 vs. 6.80±4.35 pg/ml, P<0.05), and the concentrations of OPG and 25(OH)VitD3 in serum were significantly lower than health group (156.34±57.33 vs. 189.16±68.70 pg/ml and 43.66±31.27 vs. 59.04±21.56 mmol/L, P<0.05). Serum RANKL in children with SLE was positively correlated with the duration of SLE, accumulated dose of GC(r=0.593, 0.727, P<0.05). And it was negatively correlated with serum OPG and 25(OH)VitD3 (r=-0.601, -0.469, P<0.05). In addition, serum OPG and 25(OH)VitD3 concentrations were inversely correlated with accumulated dose of GC (r=-0.66, -0.508, P<0.05). Conclusion: Low levels of vitamin D3 and bone metabolic abnormalities were found in children with SLE under the condition of disease remission, while serum RANKL expression was elevated, OPG expression was reduced. These changes associated with the duration of SLE, accumulated dose of GC. In the case of exclusion of disease activity, GC and other factors may be involved in the occurrence and development of abnormal bone metabolism through RANKL/OPG.
The training effects of a continuing education program on nurses’ knowledge and attitudes to palliative care: a cross sectional study
Authors: Chen Xian , Zhang Yuxi , Arber Anne , Huo Xiaorong , Liu Jin , Sun Cuihua , Yuan Ling , Wang Xuemei , Wang Dan , Wu Jinfeng , Du Junjie 
Published: February 2022

Abstract
Background: Most nurses in China have not been trained to take care of end-of-life patients appropriately due to lack of educational resources and insufficient training. A palliative care program was launched by the Jiangsu Nursing Association (JNA training program) and to identify gaps in palliative care training. The main aims of this study were to evaluate the training effects of the JNA training program on nurses’ knowledge and attitudes to palliative care. Methods: A cross-sectional study was conducted with 10 048 registered nurses in all regions of Jiangsu. All participants completed an online questionnaire using the Chinese version of The Palliative Care Quiz for Nursing (PCQN-C) and the Frommelt Attitude Toward Care of the Dying scale (FATCOD-B-C). A propensity score matched analysis was performed between the nurses who had attended the JNA training program and whose who hadn’t.Results: The average score of PCQN-C among all nurses was 8.79, while the mean score of the FATCOD-B-C was 103.62. Those participants who attended the JNA training program had significantly better scores than those who did not. Propensity score matching analysis showed that the palliative care training program failed to improve nurses’ knowledge in psychosocial and spiritual care or their attitudes towards the necessity of family support although there was positive impact on other aspects of palliative care.Conclusions: Knowledge of palliative care among Chinese nurses remains low. Training programs may improve general knowledge and attitudes to palliative care. However, important aspects of knowledge such as communication skills, family support, and psychosocial aspects of care, are missing. These gaps should be filled in future palliative care training programs targeting nurses with oriental culture background.
Engineering nanoscale hypersonic phonon transport
Authors: Florez Omar , Arregui Guillermo , Albrechtsen Marcus , Ng Ryan , Gomis-Bresco Jordi , Stobbe Søren , Torres Clivia Sotomayor , García Pedro David 
Published: February 2022

Abstract
Controlling the vibrations in solids is crucial to tailor their mechanical properties and their interaction
with light. Thermal vibrations represent a source of noise and dephasing for many physical processes at the quantum level. One strategy to avoid these vibrations is to structure a solid such that it possesses a phononic stop band, i.e., a frequency range over which there are no available mechanical modes. Here, we demonstrate the complete absence of mechanical vibrations at room temperature over a broad spectral window, with a 5.3 GHz wide band gap centered at 8.4 GHz in a patterned silicon nanostructure membrane measured using Brillouin light scattering spectroscopy. By constructing a line-defect waveguide, we directly measure GHz localized modes at room temperature. Our experimental results of thermally excited guided mechanical modes at GHz frequencies provides an efficient platform for photon-phonon integration with applications in optomechanics and signal processing transduction.
The role of personal interview and cognitive abilities at admission to medical school in predicting performance of medical students in internal medicine sub-internship
Authors: Liberty Idit F , Novack Lena , Hershkovitz Reli , Katz Amos 
Published: February 2022

Abstract
Admission process to medical school is a complicated task, stemming from the unresolved debates on a set of skills defining an ideal physician. The Goldman school at Ben-Gurion University in Israel is known for weighing a great emphasis on personality domain on top of academic excellence, by administering 1-hour long consecutive interviews embedded into the admission process. We compared the skills evaluated during the admission process with the students’ performance at the internal medicine rotation in their last (6th) year of medical school. Evaluations were administered by medical personnel and included questions prompting to choose those with the most potential to be a good internist.Interview evaluation at admission was associated with higher chances of being evaluated as a good internist 6 years later (Odds Ratio (OR)=9.4, p-value=0.049), independent of the students' gender (OR for male vs female=0.2, p-value=0.025) and age (OR=1.3 per each year, p-value=0.115). Our study shows that a high personal evaluation of a candidate is indicative of high personal evaluation of a student's performance at the internal medicine department 6 years later. These findings strengthen and emphasize the importance of using a personal semi structured interview in the admission process to medical school.
Nano-scale mechanism of crack nucleation/propagation and lithium penetration in solid electrolyte
Authors: Diaz Megan , Tu Qingsong , Kushima Akihiro 
Published: February 2022

Abstract
This work presents a direct observation and quantification of the fundamental mechanism of lithium penetration in Li6PS5Cl (LPS) solid electrolyte. Lithium plating in a nano-sized defect on the LPS surface led to the nucleation and propagation of a crack without external force. It also revealed a reduction in the mechanical strength of LPS when altering the electrochemical charge/discharge bias condition. A first principles atomistic simulation was performed to confirm that the disorder in the crystal structure of the LPS, both in lithium deficient and excess states, contributes to the reduced mechanical strength, and a decrease in the modulus is observed when lithium concentration is decreased from the stoichiometric amount. The results of this study suggest the importance of minimizing defects at the surface and grain boundaries to improve the stability of the solid-state electrolyte (SSE). Interfaces and boundaries can be bottlenecks for lithium diffusion, creating the concentration gradient. This can reduce the mechanical stabilities of the SSE, accelerating lithium penetration and degradation in all-solid-state lithium batteries. The insights obtained in this study provide useful information towards understanding the mechanism and designing the materials/structures to solve this issue.