bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corruption in international commercial arbitration—Domino effect in the energy industry, developing countries, and impact of English public policy
Authors: Okoli Pontian N 
Published: March 2022

Abstract
Corruption has relentlessly posed a major challenge to investors especially in developing countries. However, less attention has been focused on such developing countries from the standpoint of individuals who are indirectly affected by corrupt practices. The relationship between international commercial arbitration, the role of domestic courts and the enforcement of obligations has come under more scrutiny with large awards. Successful parties bring many award enforcement proceedings in England because of the invaluable assistance which English courts provide. Sometimes, there are allegations of corruption with respect to these awards that parties seek to enforce. In this context, English court decisions have significant implications for many parties around the world. However, the traditional narrow interpretation of public policy has come under increasing strain. This article examines how English courts have navigated the matrix of fraud, corruption and public policy-overlapping areas which parties exploit in international commercial arbitration. There is a major argument in favour of striking a balance between various institutional, governmental and people’s interests in dealing with difficult cases.
Characterization of trichome-specific BAHD acyltransferases involved in acylsugar biosynthesis in Nicotiana tabacum
Authors: Chang Aixia , Hu Zhongyi , Chen Biao , Vanderschuren Herve , Chen Ming , Qu Yafang , Yu Weisong , Li Yangyang , Sun Huiqing , Cao Jianmin , Vasudevan Kumar , Li Chenying , Cao Yanan , Zhang Jianye , Shen Yeming , Yang Aiguo , Wang Yuanying 
Published: March 2022

Abstract
Glandular trichomes of tobacco (Nicotiana tabacum) produce blends of acylsucroses that contribute to defence against pathogens and herbivorous insects, but the mechanism of assembly of these acylsugars has not yet been determined. In this study, we isolated and characterized two trichome-specific acylsugar acyltransferases that are localized in the endoplasmic reticulum, NtASAT1 and NtASAT2. They sequentially catalyse two additive steps of acyl donors to sucrose to produce di-acylsucrose. Knocking out of NtASAT1 or NtASAT2 resulted in deficiency of acylsucrose; however, there was no effect on acylsugar accumulation in plants overexpressing NtASAT1 or NtASAT2. Genomic analysis and profiling revealed that NtASATs originated from the T subgenome, which is derived from the acylsugar-producing diploid ancestor N. tomentosiformis. Our identification of NtASAT1 and NtASAT2 as enzymes involved in acylsugar assembly in tobacco potentially provides a new approach and target genes for improving crop resistance against pathogens and insects.
MADS2 regulates priming defence in postharvest peach through combined salicylic acid and abscisic acid signaling
Authors: Li Chunhong , Lei Changyi , Wang Kaituo , Tan Meilin , Xu Feng , Wang Jinsong , Zheng Yonghua 
Published: March 2022

AbstractMADS-box genes play well-documented roles in plant development, but relatively little is known regarding their involvement in defence responses. In this study, pre-treatment of peach (Prunus persica) fruit with β-aminobutyric acid (BABA) activated resistance against Rhizopus stolonifer, leading to a significant delay in the symptomatic appearance of disease. This was associated with an integrated defence response that included a H2O2 burst, ABA accumulation, and callose deposition. cDNA library screening identified nucleus-localized MADS2 as an interacting partner with NPR1, and this was further confirmed by yeast two-hybrid, luciferase complementation imaging, and co-immunoprecipitation assays. The DNA-binding activity of NPR1 conferred by the NPR1–MADS2 complex was required for the transcription of SA-dependent pathogenesis-related (PR) and ABA-inducible CalS genes in order to gain the BABA-induced resistance, in which MAPK1-induced post-translational modification of MADS2 was also involved. In accordance with this, overexpression of PpMADS2 in Arabidopsis potentiated the transcription of a group of PR genes and conferred fungal resistance in the transgenic plants. Conversely, Arabidopsis mads2-knockout lines showed high sensitivity to the fungal pathogen. Our results indicate that MADS2 positively participates in BABA-elicited defence in peach through a combination of SA-dependent NPR1 activation and ABA signaling-induced callose accumulation, and that this defence is also related to the post-translational modification of MADS2 by MAPK1 for signal amplification.
Premetazoan Origin of Neuropeptide Signaling
Authors: Yañez-Guerra Luis Alfonso , Thiel Daniel , Jékely Gáspár 
Published: March 2022

AbstractNeuropeptides are a diverse class of signaling molecules in metazoans. They occur in all animals with a nervous system and also in neuron-less placozoans. However, their origin has remained unclear because no neuropeptide shows deep homology across lineages, and none have been found in sponges. Here, we identify two neuropeptide precursors, phoenixin (PNX) and nesfatin, with broad evolutionary conservation. By database searches, sequence alignments, and gene-structure comparisons, we show that both precursors are present in bilaterians, cnidarians, ctenophores, and sponges. We also found PNX and a secreted nesfatin precursor homolog in the choanoflagellate Salpingoeca rosetta. PNX, in particular, is highly conserved, including its cleavage sites, suggesting that prohormone processing occurs also in choanoflagellates. In addition, based on phyletic patterns and negative pharmacological assays, we question the originally proposed GPR-173 (SREB3) as a PNX receptor. Our findings revealed that secreted neuropeptide homologs derived from longer precursors have premetazoan origins and thus evolved before neurons.
Higher order risk attitudes in the time of COVID-19: an experimental study
Authors: Mussio Irene , Sosa Andrés Maximiliano , Kidwai Abdul H 
Published: March 2022

Abstract
The coronavirus disease (COVID-19) represents a large increase in background risk for individuals. Like the COVID-19 pandemic, extreme events (e.g. financial downturns, natural disasters, and war) have been shown to change attitudes towards risk. Using a risk apportionment approach, we examine whether risk aversion as well as higher order risk attitudes (HORAs) (prudence and temperance) have changed during COVID-19. This methodology allows us to measure model-free HORAs. We include prudence and temperance as higher order measures, as these two have been largely understudied under extreme events but are determinants of decisions related to the health and financial domains. Once we account for socio-demographic characteristics, we find an overall increase in risk aversion during COVID-19. We also find similar results using a hypothetical survey question which measures willingness to take risks. We do not find changes in prudence and temperance using the risk apportionment methodology.
HIV Testing Approaches to Optimize Prevention and Treatment for Key and Priority Populations in Malawi
Authors: Rucinski Katherine , Masankha Banda Louis , Olawore Oluwasolape , Akolo Chris , Zakaliya Allison , Chilongozi David , Schwartz Sheree , Wilcher Rose , Persaud Navindra , Ruberintwari Melchiade , Baral Stefan 
Published: March 2022

Abstract

Background
Despite progress in improving antiretroviral therapy (ART) for people with HIV in Malawi, the burden of HIV infections and HIV treatment outcomes among key populations is suboptimal. Client-centered differentiated service delivery approaches may facilitate addressing HIV prevention and treatment needs of key populations in Malawi.

Methods
De-identified program data routinely collected as part of the LINKAGES project–Malawi were assembled from October 2017 to September 2019. HIV case finding was compared across different testing modalities for each population. Poisson regression was used to estimate the association between testing modalities and ART initiation.

Results
Of the 18 397 people included in analyses, 10 627 (58%) were female sex workers (FSWs), 2219 (12%) were men who have sex with men (MSM), and 4970 (27%) were clients of FSWs. HIV case finding varied by modality and population, with index testing and enhanced peer outreach demonstrating high yield despite reaching relatively few individuals. FSWs who tested positive through risk network referral testing were more likely to initiate ART within 30 days compared with those who tested positive through clinic-based testing (adjusted risk ratio [aRR], 1.50; 95% CI, 1.23–1.82). For MSM, index testing (aRR, 1.45; 95% CI, 1.06–2.00) and testing through a drop-in center (aRR, 1.82; 95% CI, 1.19–2.78) were associated with 30-day ART initiation.

Conclusions
These data suggest that differentiated HIV testing and outreach approaches tailored to the needs of different key populations may facilitate improved ART initiation in Malawi. Achieving 0 new infections by 2030 suggests the need to adapt treatment strategies given individual and structural barriers to treatment for key populations with HIV in high-prevalence settings.
Association of Lower Exposure Risk With Paucisymptomatic/Asymptomatic Infection, Less Severe Disease, and Unrecognized Ebola Virus Disease: A Seroepidemiological Study
Authors: Kelly J Daniel , Frankfurter Raphael G , Tavs Jacqueline M , Barrie Mohamed Bailor , McGinnis Timothy , Kamara Mohamed , Freeman Adams , Quiwah Komba , Davidson Michelle C , Dighero-Kemp Bonnie , Gichini Harrison , Elliott Elizabeth , Reilly Cavan , Hensley Lisa E , Lane H Clifford , Weiser Sheri D , Porco Travis C , Rutherford George W , Richardson Eugene T 
Published: March 2022

Abstract

Background
It remains unclear if there is a dose-dependent relationship between exposure risk to Ebola virus (EBOV) and severity of illness.

Methods
From September 2016 to July 2017, we conducted a cross-sectional, community-based study of Ebola virus disease (EVD) cases and household contacts of several transmission chains in Kono District, Sierra Leone. We analyzed 154 quarantined households, comprising both reported EVD cases and their close contacts. We used epidemiological surveys and blood samples to define severity of illness as no infection, pauci-/asymptomatic infection, unrecognized EVD, reported EVD cases who survived, or reported EVD decedents. We determine seropositivity with the Filovirus Animal Nonclinical Group EBOV glycoprotein immunoglobulin G antibody test. We defined levels of exposure risk from 8 questions and considered contact with body fluid as maximum exposure risk.

Results
Our analysis included 76 reported EVD cases (both decedents and survivors) and 421 close contacts. Among these contacts, 40 were seropositive (22 paucisymptomatic and 18 unrecognized EVD), accounting for 34% of the total 116 EBOV infections. Higher exposure risks were associated with having had EBOV infection (maximum risk: adjusted odds ratio [AOR], 12.1 [95% confidence interval {CI}, 5.8–25.4; trend test: P &lt; .001) and more severe illness (maximum risk: AOR, 25.2 [95% CI, 6.2–102.4]; trend test: P &lt; .001).

Conclusions
This community-based study of EVD cases and contacts provides epidemiological evidence of a dose-dependent relationship between exposure risk and severity of illness, which may partially explain why pauci-/asymptomatic EBOV infection, less severe disease, and unrecognized EVD occurs.
Modification of a Lie-algebra-based approach and its application to asymptotic symmetries on a Killing horizon
Authors: Tomitsuka Takeshi , Yamaguchi Koji 
Published: March 2022

Abstract
We develop a new approach to find asymptotic symmetries in general relativity as a modification of the Lie-algebra-based approach proposed in T. Tomitsuka et al. [Classical Quantum Gravity 38, 225007 (2021)]. Those authors proposed an algorithmic protocol to investigate asymptotic symmetries. In particular, their guiding principle helps us to find a non-vanishing charge that generates an infinitesimal diffeomorphism. However, in order to check the integrability condition for the charges, it is necessary to solve differential equations to identify the integral curve of vector fields, which is usually quite hard. In this paper, we provide a sufficient condition of the integrability condition that can be checked without solving any differential equations, avoiding the difficulties in the approach in the above reference. As a demonstration, we investigate the asymptotic symmetries on a Killing horizon and find a new class of asymptotic symmetries. In 4D spacetimes with a spherical Killing horizon, we show that the algebra of the corresponding charges is a central extension of the algebra of vector fields.
Effects of weaning method on postweaning performance by early weaned beef calves
Authors: Jaeger John R , Preedy Garrett W , Waggoner Justin W , Harmoney Keith R , Olson K C 
Published: March 2022

Abstract
Health and performance of early-weaned steers were evaluated during a 56-d weaning period, a 56-d feedlot receiving period, and a 165-d feedlot finishing period. Steers (n = 239; 128 ± 14 d of age) were assigned to a 56-d weaning treatment: drylot weaning (D) or pasture weaning (P). Pasture steers grazed mature, native tallgrass range (89.2% dry matter [DM], 9.08% crude protein [CP]), without supplementation. A concentrate-based diet (18.7% CP and 1.15 Mcal NEg/kg) was fed to D steers. Later, all steers were transitioned to a receiving, then a finishing diet and fed to a common endpoint. Body weight (BW) after and average daily gain (ADG) during weaning were greater (P &lt; 0.01) for D than for P. Incidence of undifferentiated fever during weaning tended to be greater (P = 0.10) for D steers than for P steers. Conversely, incidence of keratoconjunctivitis was greater (P &lt; 0.01) for P than for D during weaning (40.2% vs. 0%, respectively) and receiving (P &lt; 0.01; 14.3% vs. 1.6%, respectively). At the start and end of receiving, D steers had greater (P &lt; 0.01) BW compared with P steers. Drylot steers had greater (P = 0.03) ADG compared with P steers during receiving. Pasture steers tended to have greater dry matter intake (DMI) (P = 0.09) during receiving than D steers. In contrast, gain:feed (G:F) was improved (P &lt; 0.01) for P steers than for D steers during receiving. Incidence of undifferentiated fever was not different (P = 0.99) between D and P steers during receiving. At start of finishing, D steers were heavier (P &lt; 0.01) than P steers; however, finishing ADG was greater (P &lt; 0.01) for P compared with D. Conversely, hot carcass weight of P steers was less (P &lt; 0.01) compared with D steers. Drylot steers had greater DMI (P &lt; 0.01) than P steers during finishing, whereas P steers had improved G:F (P &lt; 0.01) compared with D steers. There were no differences (P ≥ 0.19) between treatments in DOF, carcass characteristics or United States Department of Agriculture yield grade. Growth and health during a 56-d weaning period and a 56-d receiving period were improved when steers were weaned in a drylot environment and fed a concentrate-based diet compared with non-supplemented steers weaned in a pasture environment. We interpret these data to suggest that, under the conditions of our experiment, steers preconditioned on mature, native, warm-season pasture for 56 d without supplementation were unable to compensate for previous nutrient restriction during finishing.
Testing palaeodrainage hypotheses in south-eastern Brazil: phylogeography of the sinistral livebearer fish of the genus Phalloceros (Cyprinodontiformes: Poeciliidae)
Authors: Souto-Santos Igor C A , Jennings W Bryan , Buckup Paulo A 
Published: March 2022

Abstract
The ‘sinistral Phalloceros group’ consists of three species, P. aspilos, P. leptokeras and P. tupinamba, that belong to Phalloceros, a genus of freshwater fish endemic to South America. They inhabit the Paraíba do Sul Basin and coastal drainages in south-eastern Brazil. This group is diagnosed by large hooks in the medial portion of the gonopodial appendices in males and the sinistral direction of the urogenital papilla in females. We conducted a phylogeographic analysis of mitochondrial (COI and Cytb) and nuclear (RAG1) haplotypes of 36 individuals sampled from 11 localities to test the hypothesis that the biogeographic history of sinistral Phalloceros was mediated by connections of coastal basins caused by lowered sea-levels during the Quaternary. We evaluated the taxonomic status of these nominal taxa by integrating molecular species delimitation methods and morphological data. Our results suggest that the three nominal taxa are synonyms, and P. leptokeras is designated as the valid species name. The geographic expansion of the P. leptokeras lineage began in the coastal region (~2.3 Mya). The phylogeographic relationships among populations partially corroborate the palaeodrainage model, but also suggest that P. leptokeras colonized the inland Paraíba do Sul drainage, overcoming the Serra do Mar mountains.
Nanoparticle therapy for head and neck cancers
Authors: Hoffmann Caroline , Shen Colette , Le Tourneau Christophe 
Published: March 2022

Purpose of review
The current review focuses on the therapeutic use of nanoparticles in head and neck cancer (HNC), highlighting nanoparticles at the most advanced clinical development stages.

Recent findings
Literature review covers the three main approaches for therapeutic use of nanoparticles in HNC: first, enhancing radiotherapy effect; second, performing targeted delivery of chemotherapy, immunotherapy, or genome editing molecules; third, photothermal therapy.

Summary
Nanoparticles are spherical nanoscale objects that have application in cancer therapies. Nanoparticles have diverse and often composite structure composition to ensure their function, increase their bioavailability in tumor tissues, and decrease off-target effects, sometimes by means of activating internal or external stimuli. Hafnium oxide nanoparticles are being tested in phase I to III trials for radiotherapy enhancement. Nanoparticle-based delivery of paclitaxel, cisplatin, and of the immune activator CpG-A DNA is being evaluated in phase II trials. No nanoparticle is currently approved for HNC treatment.
Core Homologous Recombination Mutations and Improved Survival in Nonpancreatic GI Cancers
Authors: Tan Elaine , Whiting Junmin , Knepper Todd , Xie Hao , Imanirad Iman , Carballido Estrella , Felder Seth , Frakes Jessica , Mo Qianxing , Permuth Jennifer B. , Somerer Katelyn , Kim Richard , Anaya Daniel A. , Fleming Jason B. , Walko Christine , Sahin Ibrahim H. 
Published: March 2022

Introduction:
Homologous recombination mutations (HRM) have led to increased responses to platinum chemotherapy in pancreatic cancer. However, HRMs’ role in nonpancreatic gastrointestinal (GI) cancers remains to be determined. Our objective was to evaluate the prognostic and predictive role of core (BRCA1, BRCA2, PALB2) and noncore HRM in nonpancreatic GI cancers receiving platinum therapy.

Materials and Methods:
This study performed at Moffitt Cancer Center included metastatic nonpancreatic GI cancer patients treated with platinum therapy. All patients had either a core or noncore HRM, determined by next generation sequencing. Response rates, median progression-free survival (PFS), and median overall survival (OS) were determined and compared between core versus noncore HRM patients.

Results:
In the study, 69 patients with one or more HRM were included: 63.8% were male, 87.0% were Caucasian, and 47.9% had colorectal cancer. Twenty-one (30.4%) patients had a core HRM and 48 (69.6%) had a noncore HRM. Among evaluable patients (n=64), there was no significant difference in objective response: 20.0% with core HRM versus 22.7% with noncore HRM responded to platinum therapy (P=0.53). Median PFS was 10.4 months versus 7.1 months for core HRM versus noncore HRM, respectively (P=0.039). Median OS was 68.9 months versus 24.3 months (P=0.026) for core HRM versus noncore HRM, respectively.

Conclusions:
Our study demonstrated response of core and noncore HRM to platinum therapy in metastatic nonpancreatic GI malignancies, suggesting benefit in both groups. Core HRM patients had significantly increased median OS and median PFS compared with those with noncore HRM, suggesting potential prognostic and predictive significance. Larger prospective studies are needed to confirm our findings.
Long-acting preexposure prophylaxis in low- and middle-income countries: key considerations for implementation
Authors: Kaewpoowat Quanhathai , Chariyalertsak Suwat , Phanuphak Nittaya , Ramautarsing Reshmie A. 
Published: March 2022

Purpose of review
HIV preexposure prophylaxis (PrEP) is a key tool in ending the HIV epidemic. Long-acting cabotegravir (LA- CAB) phase II/III studies revealed promising efficacy in preventing HIV acquisition. Here, we discuss key considerations for implementing LA-CAB in low- and middle-income countries (LMIC).

Recent findings
PrEP roll out in LMIC is still far from ideal, and contextual factors within LMIC vary widely. Implementation science studies are urgently needed to optimize the implementation of LA-CAB in different settings, consider effective service delivery models, and ensure program sustainability. Preferences and concerns regarding LA-CAB among potential users are unknown but likely specific to local context. Demedicalized and simplified PrEP service delivery increases uptake, and ways to safely and effectively do the same for LA- CAB need to be explored. Although ideally LA-CAB should be an additional choice of HIV prevention method, its cost will be the major determinant in deciding its position as a first line choice or restricted second-line option.

Summary
LA-CAB has the potential to enhance PrEP uptake. However, several implementation challenges need to be explored and addressed to ensure it can be accessed and utilized in different settings by those who need it the most.
Barbed PDO Thread Face Lift: A Case Study of Bacterial Complication
Authors: Surowiak Paweł 
Published: March 2022

Summary:
Procedures with polydioxanone (PDO) threads are increasingly used for aesthetic indications. To date, eight cases of serious complications following the use of PDO threads have been published. In this case report, we present a case of a serious bacterial complication after a procedure with four PDO threads. A 52-year-old female patient presented to our center 1 month after undergoing the procedure at another center. Despite early symptoms, no treatment had previously been implemented. Perforating abscesses were found along the course of the threads. After 5 days of antibiotic therapy (amoxicillin 875 mg and clavulanic acid 125 mg p.o. every 12 hours), the threads were surgically removed due to skin rippling. During the procedure, the threads were found to be fragile, and several incisions were necessary to remove them. After 1 month, no signs of inflammation were reported. However, persistent deformities occurred due to delayed treatment implementation. Bacterial complications seem to be a typical complication following the procedure with PDO threads. PDO threads can be difficult to remove due their fragility. The possible need for surgical removal of the threads should be considered when selecting areas for application.