bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole blood donor return rates after deferral for tattooing or body piercing—Survey across blood donation services: The BEST collaborative study
Authors: Quee Franke , O'Brien Sheila F. , Prinsze Femmeke , Steele Whitney R. , Grégoire Yves , Cutajar Alexandra , Wendel Silvano , Compernolle Veerle , Goldman Mindy , van den Hurk Katja ,   Biomedical Excellence for Safer Transfusion (BEST) Collaborative
Published: June 2022

AbstractBackground and ObjectivesTo protect transfusion recipients from transfusion‐transmissible infections, blood donors are deferred from donating after recent tattooing or piercing. To explore to what extent and how this deferral impacts donor availability, we performed an international study to investigate how many donors were deferred for a recent tattoo or piercing and how many of these donors returned to donate.Materials and MethodsWe surveyed blood centre members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative and the European Blood Alliance Donor Studies Working Group on their numbers of donations, tattoo and piercing deferrals, and return rates in the year 2017.ResultsEight blood centres participated. Overall, deferral rates were lower for repeat donors compared to new donors. Repeat donors were more likely to return than new donors. Women and young donors were more often deferred than male and older donors. Men were more demotivated by tattoo or piercing deferral, resulting in lower return rates compared to women. Return rates differed greatly between blood centres.ConclusionTattoo and piercing deferrals lead to missed donations and result in lower return rates. However, the numbers vary largely internationally, probably due to cultural and policy differences. Shortening deferral periods after tattooing or piercing may reduce the impact on donor availability, which should be investigated in single‐centre studies.
The Discussion About the Identification of the Anand Model Parameters and Two Alternative Identification Methods
Authors: Xu Yuqian , Zeng Qiwen , Wang Yuexing , Wu Mingyong , Chen Xiangyu , Chen Gang 
Published: June 2022

Abstract
The Anand model is a unified viscoplastic model, which is widely employed to describe the solder material deformation. The parameters in the Anand model for a certain material are usually identified by using the classical method based on two algebraic equations derived from the original differential equation of the Anand model. However, the second algebraic equation describing the relationship between the stress and inelastic strain is obtained with some terms about the unsteady value of internal variable neglected. But the effects induced by the omission of some unsteady terms on the effectiveness of classical method are not researched comprehensively. Therefore, in this paper, the effects of the omitted terms on the accuracy of the classical method are discussed. The inelastic deformation for the material which the second algebraic equation cannot describe due to the omission of unsteady terms is presented. The precondition for obtaining accurate results from the second algebraic equation is given out. Two criteria used to judge the effectiveness of the second algebraic equation are derived. To reduce the error related to the second algebraic equation of the classical method for some materials, two alternative identification methods are proposed. By combining the step of solving differential equation and genetic algorithm, the parameters in the Anand model originally identified by the second algebraic equation are determined in the processes of the two proposed methods. The effectiveness of the two alternative methods is presented by identifying the material Anand parameters where the classical method cannot be applied.
Imprinted Glass Fiber-Reinforced Epoxy Nanocomposites Vascular Self-Healing Wind Turbine Blades
Authors: Saadeh Walaa H. , Qandil Mohammad D. , Amano Ryoichi S. 
Published: June 2022

Abstract
Wind energy is a primary renewable energy source and has been one of the most promising sources of clean, long-term energy. Self-healing is the autonomous ability to recover from failure. Self-healing material systems in wind turbine blades can reduce maintenance, repair, and energy compensation costs. Investigation of the self-healing wind turbine blades is of core interest in this study. This paper initially introduces self-healing properties into vacuum-assisted resin transfer molding molded fiber-reinforced polymer (FRP) nanocomposites and lab preparation for studying the effect of incorporation of carbon nanotubes (CNTs) on the self-healing capabilities using dicyclopentadiene (DCPD) and Grubbs first-generation catalyst. A vascular network was imprinted in a single glass fiber FRP sheet utilizing hexagonal 3D printed templates, infused with DCPD, and later embedded into a multilayer FRP. The effect of adding epoxy resin with 0.3 wt% CNTs to the multilayer FRP was investigated. The samples were tested before and after recovery by performing the three-point bending test. The maximum flexural strengths and percent recovery for the non-healed and healed FRP samples were calculated. Interestingly, the strength of the samples increased at least ten times after the addition of CNTs to the composite, and the percentage of stress recovery was doubled on average.
Tailored exercise and manual therapy versus standardised exercise for patients with shoulder subacromial pain: a feasibility randomised controlled trial (the Otago MASTER trial)
Authors: Ribeiro Daniel C , Jafarian Tangrood Zohreh , Wilson Ross , Sole Gisela , Abbott J Haxby 
Published: June 2022

ObjectivesThe aim of this study was to assess whether it was feasible to conduct a full trial comparing a tailored versus a standardised exercise programme for patients with shoulder subacromial pain.DesignTwo-arm, patient-blinded and assessor-blinded, randomised controlled feasibility trial.MethodsTwenty-eight participants with shoulder subacromial pain were randomly allocated into one of two intervention groups—tailored or standardised exercise. Participants in the tailored exercise programme received exercises and manual therapy tailored to their scapular and shoulder movement impairments. Participants in the standardised exercise programme received progressive strengthening exercise. The primary outcome measures were (1) the participant recruitment rate; (2) the proportion of participants enrolled from the total number screened; (3) drop-out rates; and (4) adherence to the rehabilitation programme. Other outcome measures were: (5) pain levels; (6) Patient-Specific Functional Scale; (7) the Shoulder Pain and Disability Index; and (8) pain self-efficacy. We compared changes in pain and disability scores between groups using a repeated mixed-model analysis of variance. Since this is a feasibility study, we did not adjust alpha for multiple comparisons, and considered 75% CI as the probability threshold at 3-month follow-up. Health-related quality of life was assessed using the Short-Form 12 and quality-adjusted life years (QALYs) were estimated.ResultsThe recruitment rate was 3 participants per month, the proportion of participants enrolled was 23%, the drop-out rate was 14% and the overall adherence to the rehabilitation programme was 85%. No between-group differences were found for most outcome measures. Adverse events (n=2, only in the tailored group) were minor in nature and included skin injury or pain following taping.ConclusionsOur feasibility trial showed that additional strategies are required for improving recruitment, enrolment and minimising drop-out of participants into the trial and making it feasible to conduct a full trial.Trial registration numberANZCTR: 12617001405303.
Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol
Authors: Morillo Diana , Mena-Bucheli Santiago , Ochoa Angélica , Chico Martha E , Rodas Claudia , Maldonado Augusto , Arteaga Karen , Alchundia Jessica , Solorzano Karla , Rodriguez Alejandro , Figueiredo Camila , Ardura-Garcia Cristina , Bachmann Max , Perkin Michael Richard , Chis Ster Irina , Cruz Alvaro , Romero Natalia Cristina , Cooper Philip 
Published: June 2022

IntroductionAsthma is a growing health problem in children in marginalised urban settings in low-income and middle-income countries. Asthma attacks are an important cause of emergency care attendance and long-term morbidity. We designed a prospective study, the Asthma Attacks study, to identify factors associated with recurrence of asthma attacks (or exacerbations) among children and adolescents attending emergency care in three Ecuadorian cities.Methods and analysisProspective cohort study designed to identify risk factors associated with recurrence of asthma attacks in 450 children and adolescents aged 5–17 years attending emergency care in public hospitals in three Ecuadorian cities (Quito, Cuenca and Portoviejo). The primary outcome will be rate of asthma attack recurrence during up to 12 months of follow-up. Data are being collected at baseline and during follow-up by questionnaire: sociodemographic data, asthma history and management (baseline only); recurrence of asthma symptoms and attacks (monthly); economic costs of asthma to family; Asthma Control Test; Pediatric Asthma Quality of life Questionnaire; and Newcastle Asthma Knowledge Questionnaire (baseline only). In addition, the following are being measured at baseline and during follow-up: lung function and reversibility by spirometry before and after salbutamol; fractional exhaled nitric oxide (FeNO); and presence of IgG antibodies to SARS-CoV-2 in blood. Recruitment started in 2019 but because of severe disruption to emergency services caused by the COVID-19 pandemic, eligibility criteria were modified to include asthmatic children with uncontrolled symptoms and registered with collaborating hospitals. Data will be analysed using logistic regression and survival analyses.Ethics and disseminationEthical approval was obtained from the Hospital General Docente de Calderon (CEISH-HGDC 2019-001) and Ecuadorian Ministry of Public Health (MSP-CGDES-2021-0041-O N° 096-2021). The study results will be disseminated through presentations at conferences and to key stakeholder groups including policy-makers, postgraduate theses, peer-review publications and a study website. Participants gave informed consent to participate in the study before taking part.
Predictive role of modifiable factors in stroke: an umbrella review
Authors: Wang Xiaotong , Liang Man , Zeng Fanxin , Wang Yue , Yang Yuetian , Nie Fangfang , Shang Mengke , Ta Na , Wen Lu , Ou Lanxin , Yang Zhibin , Liu Wanyang 
Published: June 2022

BackgroundA growing number of meta-analyses reviewed the existing associations between modifiable factors and stroke. However, the methodological quality of them and quality of evidence remain to be assessed by validated tools. Thus, this umbrella review was conducted to consolidate evidence from systematic reviews and meta-analyses of cohort studies investigating the association between modifiable factors and incidence of stroke.MethodsPubMed, Web of Science, Embase, Wanfang and China National Knowledge Infrastructure databases for systematic reviews and meta-analyses of cohort studies from inception until March 2021. Assess the methodological quality of systematic reviews 2 was used to evaluate the methodological quality of each included published meta-analysis. Excess significance test was used to investigate whether the observed number of studies (O) with nominally significant results (‘positive’ studies, p<0.05) was larger than the expected number of significant results (E). Statistically significant (p<0.05) associations were rated into five levels (strong, highly suggestive, suggestive, weak and no) using specific criteria. Sensitivity analyses were performed.Results2478 records were identified through database searching. At last, 49 meta-analyses including 70 modifiable factors and approximately 856 801 stroke cases were included in the present review. The methodological quality of three meta-analyses was low, while others were critically low. Evidence of walking pace was strong. High suggestive evidence mainly included total meat, processes meat, chocolate, sodium, obesity, pulse pressure, systolic blood pressure, diastolic blood pressure, sleep duration and smoking. Suggestive evidence mainly included dietary approaches to stop hypertension (DASH) diet, vitamin C, magnesium, depression and particulate matter 2.5. After sensitivity analyses, evidence of DASH diet, magnesium and depression turned to weak. No publication bias existed, except only one study which could be explained by reporting bias.DiscussionDiet with rich macronutrients and micronutrients, healthy dietary patterns and favourable physical, emotional health and environmental management should be promoted to decrease the burden of stroke.PROSPERO registration numberCRD42021249921.
Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis
Authors: Chockalingam Arun , Konstantinidis Menelaos , Koo Brandon , Moon John Timothy , Tran Andrew , Nourouzpour Sahar , Lawson Emily , Fox Kathleen , Habibollahi Peiman , Odisio Bruno , Loya Mohammed , Bassir Ali , Nezami Nariman 
Published: June 2022

IntroductionNon-small cell lung cancer (NSCLC) makes up the majority of lung cancer cases. Currently, surgical resection is the gold standard of treatment. However, as patients are becoming medically more complex presenting with advanced disease, minimally invasive image-guided percutaneous ablations are gaining popularity. Therefore, comparison of surgical, ablative and second-line external beam therapies will help clinicians, as management of NSCLC changes. We will conduct a meta-analysis, reviewing literature investigating these therapies in adult patients diagnosed with stage 1 NSCLC, with neither hilar nor mediastinal nodal involvement, confirmed either through cytology or histology regardless of type.Methods and analysisWe will search electronic databases (MEDLINE, Embase, Web of Science, Scopus, ClinicalTrials.gov, Cochrane) from their inception to January 2021 to identify randomised controlled trials (RCTs), cluster RCTs and cohort studies comparing survival and clinical outcomes between any two interventions (lobectomy, wedge resection, video-assisted thoracoscopic surgery/robot-assisted thoracoscopic surgery, radiofrequency ablation, microwave ablation, cryoablation and consolidated radiation therapies (external beam radiation therapy, stereotactic body radiation therapy, and 3D conformal radiation therapy). The primary outcomes will include cancer-specific survival, lung disease-free survival, locoregional recurrence, death, toxicity and non-target organ injury. We will also search published and unpublished studies in trial registries and will review references of included studies for possible inclusion. Risk of bias will be assessed using tools developed by the Cochrane collaboration. Two reviewers will independently assess the eligibility of studies and conduct the corresponding risk of bias assessments. For each outcome, given enough studies, we will conduct a network meta-analysis. Finally, we will use the Confidence in Network Meta-Analysis tool to assess quality of the evidence for each of the primary outcomes.Ethics and disseminationWe aim to share our findings through high-impact peer review. As interventional techniques become more popular, it will be important for providers in multidisciplinary teams caring for these patients to receive continuing medical education related to these interventions. Data will be made available to readers.PROSPERO registration numberCRD42021276629.
Broadening the diversity of consumers engaged in guidelines: a scoping review
Authors: Synnot Anneliese , Hill Sophie , Jauré Allison , Merner Bronwen , Hill Kelvin , Bates Peta , Liacos Alexandra , Turner Tari 
Published: June 2022

BackgroundGuideline developers are encouraged to engage patients, carers and their representatives (‘consumers’) from diverse backgrounds in guideline development to produce more widely applicable guidelines. However, consumers from diverse backgrounds are infrequently included in guidelines and there is scant research to support guideline developers to do this.ObjectivesTo identify principles and approaches to broaden the diversity of consumers engaged in guideline development.DesignScoping review and semi-structured interviews.MethodsWe conducted comprehensive searches to March 2020 for studies, reports and guidance documents. Inclusion criteria included the terms ‘consumer’ (patients, carers and their representatives), ‘diversity’ (defined using the PROGRESS-PLUS mnemonic) and ‘consumer engagement’ (the active involvement of consumers at any stage of guideline development). We also conducted four interviews with consumers and guideline developers. We used descriptive synthesis to identify themes, and summarised information about implemented approaches used to broaden diversity of consumers in guidelines.ResultsFrom 10 included documents, we identified eight themes. Themes covered general engagement concepts (Respectful partnerships; Recruitment; Expectations, process and review); specific concepts about guideline development group (GDG) engagement (Characteristics of guideline personnel; Consumers’ role, characteristics and prominence; Preparing and supporting consumers); and other (non-GDG) approaches (Online methods; Consultations and research-based approaches). The most commonly included PROGRESS-PLUS categories were Disability, Race/culture/ethnicity/language, Place of residence and Other vulnerable (eg, ‘disadvantaged groups’). Each theme included the views of both consumers and guideline developers. We found descriptions of 12 implemented engagement approaches to broaden diversity of consumers in guidelines.ConclusionsRelationship-building, mitigating power imbalances and meeting consumers where they are at underpin our findings. Engaging with diverse groups may require greater attention to building formal, respectful partnerships and employing inclusive engagement methods.
Effectiveness of a web-based virtual journal club to promote medical education (Web-Ed): protocol of a multicentre pragmatic randomised trial
Authors: Rimmer Michael , Elfaki Nagla , Dunlop Cheryl , Coleburt Damien , Cowan Neil , Raglan Olivia , Teh Jhia Jiat , Fisher Maria , Mcrobbie Sarah , Murugesu Nilaani , Ramcharn Meera , Abdelrahman Mohamed , Jibrel Yazid , Wood Matthew , Parry-Smith William , Al Wattar Bassel H 
Published: June 2022

IntroductionA journal club (JC) is a commonly used medical educational tool. Videoconferencing technology can facilitate the delivery of JCs, however, there remains no evidence on the role of web-based virtual JCs in promoting the acquisition and retention of medical knowledge. The Web-Ed trial aims to evaluate the educational benefits, feasibility and acceptability of web-based virtual JCs compared with traditional face-to-face ones.Methods and analysisWeb-Ed is a multicentre pragmatic parallel-group randomised trial across teaching hospitals within the UK National Health Service (NHS). We will enrol qualified doctors or medical students who are >18 years old, proficient in English and able to use online videoconferencing software. Block randomisation will be used to allocate participants in 1:1 ratio to either intervention group. Both groups will be presented with the same educational material and follow a standardised JC structure hosted by nominated moderators and medical faculty members.The primary outcome is the difference in participants’ knowledge acquisition and retention 7 days after the JCs evaluated using standardised multiple-choice questions. We will report secondarily on the feasibility and acceptability of the JCs using Likert scale questionnaires. Assuming a 30% drop-out rate, we aim to enrol 75 participants to detect a 20% improvement in knowledge acquisition at 80% power and 5% significance. We will report using mean difference or risk ratio with 95% CIs and assess significance using parametric/non-parametric testing. Where relevant, we will adjust for predetermined characteristics (age, grade of training and session duration) using multivariate regression analyses.Ethics and disseminationWeb-Ed was designed by doctors in training to address their learning needs and evaluate the preferred mode of learning. The trial results will be published in peer-reviewed journals and presented at relevant scientific conferences. The trial has been approved by the NHS Health Regulation Authority (21/HRA/3361).Trial registration numberISRCTN18036769.
cfDNA as a surrogate marker for COVID-19 severity in patients with influenza-like symptoms with and without SARS-CoV-2 infections in general practice: a study protocol for a prospective cohort study
Authors: Dehnen Dorothea , Neuberger Elmo , in der Schmitten Jürgen , Giagkou Ekaterini , Simon Perikles , Botzenhardt Suzan 
Published: June 2022

IntroductionThe clinical course of patients with a SARS-CoV-2 (COVID-19) infection varies widely, from symptom-free to severe courses that can lead to death. Laboratory values of SARS-CoV-2 patients such as lymphocyte counts or C-reactive protein (CRP) do not allow a prediction of the actual course of the disease. To identify a possible predictive marker for the differentiation and prognosis of illness with influenza-like symptoms with and without SARS-CoV-2 infections in general practice, we will analyse the concentrations of cell-free DNA (cfDNA) levels, laboratory and clinical parameters, temperature, oxygen saturation, breathing rate and concomitant symptoms in patients with flu-like symptoms with and without a SARS-CoV-2 infection.Methods and analysisThis is a single-centre, two-arm, parallel longitudinal cohort study with a total of 44 patients. 22 patients with flu-like symptoms without a SARS-CoV-2 infection and 22 patients with flu-like symptoms with a SARS-CoV-2 infection will be recruited. The primary objective is to compare cfDNA levels in ambulatory patients in general practice with flu-like symptoms with SARS-CoV-2 infection with those with influenza like symptoms without a SARS-CoV-2 infection during the disease (day 7 and day 14). The secondary objective is to determine whether there is a correlation between cfDNA concentrations on the one hand, and laboratory and clinical parameters on the other hand. cfDNA, differential blood count, high-sensitive CRP and erythrocyte sedimentation rate will be measured in blood samples, concomitant symptoms will be surveyed via a self-assessment questionnaire, and oxygen saturation, breathing rate and examination of the lungs will be reported by treating physicians.Ethics and disseminationEthical approval was issued on 1 March 2021 by the Ethics Committee Essen under the number 21-9916-BO. Findings will be published in peer-reviewed open-access journals and presented at national and international conferences.Trial registration numberDRKS00024722.