bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biochemical Assessment of Cardiovascular Risk Associated with the Duration of Antipsychotic Therapy in Patients with Schizophrenia
Authors: Akande A A , Adelekan A , Abdulazeez I M 
Published: July 2022

Background and objectives: Schizophrenia accounts for 78% of cases managed in Behavioural Sciences in Nigeria, and treatments with antipsychotic drugs may contribute to the onset of coronary heart disease (CHD) due to dyslipidaemia - associated complications. The prevention of CHD is preferable and less expensive than its management; thus, early identification and treatment may offer the possibility of reducing the devastating sequel. The aim of this study was to investigate the pattern of dyslipidaemia and cardiovascular risk (CVR) associated with duration of antipsychotic therapy inorder to improve awareness on early diagnosis, treatment and CVR reduction.
Methods: This was a longitudinal (prospective) study involving 44 participants recruited through systematic random sampling. Each participant served as their own control. Four blood samples were obtained from each participant, starting with a baseline before the onset of antipsychotic therapy and subsequently at monthly intervals for three consecutive months from commencement of therapy. Parameters of routine and advanced lipid profiles were assayed and the atherogenic indices were calculated.
Results: Both the routine and advanced lipid profiles werewithin reference limits at baseline. A significant increase in monthly levels was observed with dyslipidaemia noticed by the second month of antipsychotic therapy. There was an association established between the duration of therapy and a high CVR. The TC/HDL-C ratio performed better than apo B-100 and individual routine lipid profile fractions in the evaluation of CVR.
Conclusions: Dyslipidaemia associated with high CVR may develop with antipsychotic therapy. Calculation of atherogenic indices was a good indicator of CVR.
Keywords: Antipsychotics; Cardiovascular risk; Dyslipidaemia; Schizophrenia.
Clinical Audit of Low Dose Prophylaxis Programme for Nigerian Children with Haemophilia
Authors: Tolani  
Published: July 2022

Introduction: The evidence of benefits for prophylaxis especially low dose prophylaxis is incontestable yet most children in developing countries as Nigeria do not have access to this treatment protocol.
Aim: The aim was to audit the low dose prophylaxis treatment in Nigerian children with haemophilia.
Methodology: A multicentre clinical audit of five haemophilia treatment centres; University of Nigeria Teaching Hospital Enugu, Lagos University Teaching Hospital, National Hospital Abuja, University of Port Harcourt Teaching Hospital Port Harcourt, and Federal Teaching Hospital Gombe. Eighteen children with mild-severe haemophilia were enrolled into low-dose prophylaxis treatment programme. The reduction of joint bleeding, improvement of joint function and Quality of Life (QoL) during prophylaxis were analysed.
Results: In total 18 children - 17males and 1 female (median age 8 years) were enrolled. The median duration of observation was 7 months (range 3-15months). Seven of the children were on primary prophylaxis (41%) while 10 of the children (59%) were on secondary prophylaxis. The number of joint bleeds decreased from a total of 162 (individual range 5-20, mean 10.3) to 42 (range 0-7, mean 3.0) during the observation period with an overall reduction of 74%. Joint function improved in 94.1% of disease joints, while only 5.6% reported no improvement (due to poor compliance). School attendance improved in all subjects, sports participation and daily activity improved moderately.
Conclusion: Low dose prophylaxis was beneficial in reduction of joint bleeds, improvement of joint function and improvement of QoL of Children with haemophilia in Nigeria.

Authors
T U Nwagha 1, H C Okoye 1, C E Udo 2, S Yuguda 3, K I Korubo 4, T A Adeyemo 5
Evaluation of Asymptomatic Malaria Antigenaemia and Parasitaemia in Human Immunodeficiency Virus-Infected Children in Benin City, Nigeria
Authors: Ibadin  
Published: July 2022

Background: Malaria and HIV/AIDS are rampant in subSaharan Africa with prevalence of one reinforcing the other and control of one impactful on control of the other. Malaria parasitaemia (MP) prevalence is increased in HIV-infected individuals while certain drugs used in latter cause decline in MP but it is uncertain how they affect malaria antigenaemia (MA). How certain bio-social and disease characteristics affect MA and MP in this cohort is unknown.
Objectives: To determine prevalence of asymptomatic MP and MA and their clinical and social determinants in HIV infected.
Methods: In a prospective cross-sectional study carried out at the University of Benin Teaching Hospital (April to June 2016), 221 HIV-infected children (aged 1-17years) asymptomatic for malaria and 221 apparently healthy HIV-negative controls were studied. MA was assessed using rapid diagnostic test while MP was evaluated using microscopy. Standard method was used to determine parasite count.
Results: Prevalence of asymptomatic MP was 24.4% in subjects and 17.6% in controls while MA prevalence in subjects and controls were comparable (20.8% vs 18.1%). Malaria parasitaemia rate (MPr) of 24.4% was higher than malaria antigenaemia rate (MAr) (20.8%). MP and MA rates were independent of socioeconomic status, access to anti-retroviral drugs, their duration of use and clinical disease stage.
Conclusion: MA occurred frequently enough to warrant its use as malaria case definition surrogate in asymptomatic children with HIV/AIDS receiving trimethoprim-sulfamethoxazole prophylaxis and protease inhibitors.
Authors
M O Ibadin 1, N Eghafona 2
Risk Factors of Skin Diseases among School Children in South Eastern Communities in Nigeria
Authors: Ewurum  
Published: July 2022

Background: Skin disorders frequently seen among primary school children are common causes of morbidity. Determining the risk factors of skin diseases, will enhance a better understanding of skin health and prevent skin diseases in school children.
Aim: To determine the common risk factors of skin diseases among primary school children in Umuahia South Local Government Area of Abia State.
Methods: A descriptive cross-sectional study carried out over a 4-month period among pupils of public and private primary schools. Diagnosis of skin diseases was based on clinical findings as well as laboratory investigations where indicated. A pre-tested, self-administered, close ended questionnaire was used to ascertain the risk factors of skin diseases.
Results: Eight hundred and forty-seven (847) and seven hundred and thirteen (713) subjects were recruited from public and private schools respectively. Fifty-six percent of the subjects were males. The mean age of the study participants was 8.74 ± 2.08 years. The overall prevalence of skin diseases was 40.2%. Using a multivariate logistic regression, gender, number of people per room, frequency of bathing per week and source of water were found to be significant risk factors for skin diseases.
Conclusion: Socio-demographic factors and living conditions are significant risk factors of skin diseases. Standard hygienic practices by school children and their parents/ caregivers will help to reduce the high prevalence of skin diseases in our environment.
Authors
O Ewurum 1, C A Ibeneme 2, T O Nnaji 3, A N Ikefuna 4
Prevalence and Factors Associated with Depression among Resident Doctors in Nigeria: A Multi-Center Study
Authors: Obilom  
Published: July 2022

Background: Depression is a significant contributor to the global burden of disease. Several studies have shown that depression in resident doctors is more common than that in the general population. However, data on the prevalence of depression among resident doctors in Nigeria is limited.
Objectives: The aim of this study is to determine the prevalence of depression as well as factors associated with depression among resident doctors.
Methods: A cross-sectional study design was employed with semi-structured questionnaires on socio-demographic and other factors associated with depression in resident doctors. The proportionate sample size in hospitals across the six geopolitical zones with multi-stage sampling and systematic random sampling technique was used to recruit resident doctors. The Beck's Depression Inventory was employed. The data was analyzed using Epi info version 3.5.3 (2011) and Stata 14. A p-value of less than 0.05 was statistically significant.
Results: The prevalence of depression was 18.9% among the resident doctors. Negative binomial regression used showed that depression in resident doctors was significantly associated with age (IRR=1.07, 95%CI:1.01-1.13, p=0.017), female gender ((IRR=1.75, 95%CI: 1.00-3.05, p=0.049) and being a resident in the surgical specialties (IRR=2.31, 95%CI: 1.35-3.94, p=0.002), respectively.
Conclusion: The prevalence of depression among resident doctors showed that older age, female gender, and surgical specialties were determinants of depression.
Author
R E Obilom 1, C T Amanyam 1, A M Ogunbode 2, O A Mosuro 2, G U Ndukwu 3, F M Onuoha 4, B A Grema 5, M D Akangoziri 6
Pengaruh Brand Ambassador Non-Celebrity Terhadap Minat Beli Dimediasi Oleh Promosi Di Instagram (Studi Kasus Pada TMDASH.ID Di Kota Ternate)
Authors: Subhan Subhan , Dian Ekawaty  , Fahri Djohan 
Published: July 2022

Penelitian ini bertujuan untuk menguji pengaruh brand ambasador non-celebrity terhadap minat beli yang dimediasi oleh promosi online melalui media sosial. Penelitian ini menggunakan teknik kuantitatif dengan menggunakan metode survei dalam pengumpulan data. Populasi penelitian adalah konsumen TMDASH yang berlokasi di kota ternate dengan jumlah sampel sebanyak 100 responden. Teknik pengumpulan sampel yang digunakan adalah purposive sampling. Setelah melakukan analisis terhadap data, diketahui bahwa brand variabel brand ambassador non-celebrity berpengaruh positif dan signifikan terhadap variabel promosi dengan nilai t-hitung sebesar 5,646 lebih besar dari t-tabel 1,984 dengan nilai signifikansi lebih kecil dari 0,05. Variabel brand ambassador non-celebrity berpengaruh positif dan signifikan terhadap variabel minat beli dengan nilai t-hitung sebesar 4,133 lebih besar dari t-tabel 1,984 dengan nilai signifikansi lebih kecil dari 0,05. Variabel promosi berpengaruh positif dan signifikan terhadap variabel minat beli dengan nilai t-hitung sebesar 7,047 lebih besar dari t-tabel 1,984 dengan nilai signifikansi lebih kecil dari 0,05. Sedangkan variabel promosi mampu memediasi pengaruh variabel brand ambassador non-celebrity terhadap minat beli. Hal ini dibuktikan oleh nilai uji Sobel sebesar 4.3860 lebih besar dari nilai t tabel 1.66.
Impact of Teaching Short Stories on Sudanese EFL Learners’ Vocabulary learning
Authors: Mohamned Elsadig Musa Gibreel Mohammed 
Published: July 2022

The current study aimed to explore the relationship between teaching short stories and the improvement of the learners' vocabulary in the Sudanese EFL context. The study used a descriptive and analytical research design. It used a pre-test and post-test for 20 students from Khartoum University and was divided into two groups- an experimental group and a control group, with 10 participants in each group. Using statistical analysis, the findings showed that the participants who were taught using short stories improved their vocabulary in terms of increasing their word count and usage that the participants in the control group. That is to say, using short stories motivates the learners to learn new words and enables them to use such vocabulary in sentences. Reading a short story can improve students' vocabulary. With this significant result, it can be said that short stories develop learners' vocabulary and this helps EFL learners, like many other similar contexts, to develop their vocabulary through the teaching of short stories.
Keywords: ELT, EFL learners, Short stories, Sudanese Context, Vocabulary
YETİŞKİN KADINLARIN HALK EĞİTİM MERKEZİ KURSLARINA KATILMAMA NEDENLERİNİN İNCELENMESİ
Authors: ULUSOY Berru 
Published: July 2022

Eğitim, yaşam boyu devam eden bir süreç olduğundan kadının eğitimi sadece okul çağında değil, yetişkinliğinde de önemlidir. Halk Eğitim Merkezleri, açmış oldukları kurslar ile tüm yaş gruplarına, toplumun her kesimine ve kadınlara eğitim imkanı sunmaktadır. Buna karşın Türkiye’de ilkokul, ortaokul ve liseye kayıtlılar dışında kadın nüfusunun sadece yaklaşık % 15’i halk eğitim merkezlerindeki kurslara katılmaktadır. Kadın için eğitim oldukça önemli olmasına rağmen, bu oran diğer ülkelere göre düşüktür. Kadınların halk eğitim merkezlerindeki kurslara katılmama nedenlerinin tespit edilerek katılmaları için gerekli koşulların sağlanması önem taşımaktadır.
Belirtilen önem doğrultusunda yetişkin kadınların halk eğitim merkezi kurslarına katılmama nedenlerinin belirlenmesi çalışmanın amacını oluşturmaktadır. Çalışma, nitel araştırma yöntemlerinden fenomenolojik desende tasarlanmıştır. Araştırmanın çalışma grubunun belirlenmesinde amaçlı örnekleme yöntemlerinden maksimum çeşitlilik ve ölçüt örnekleme yöntemi kullanılmıştır. Çalışma grubu; Ankara ili merkez ilçelerinde yaşayan ve daha önce halk eğitim merkezlerinde hiçbir kursa katılmamış 97 kadındır. Araştırmada verilerin toplanmasında döküman inceleme ve görüşme yöntemlerine başvurulmuştur. Yarı-yapılandırılmış görüşme formu aracılığıyla elde edilen veriler içerik analiziyle çözümlenmiştir. Araştırmadan elde edilen bulgulara göre, halk eğitim merkezi kurslarına hiç katılmamış yetişkin kadınların çoğu bu durumun nedeni olarak vakit yetersizliğini öne sürmüş ve bilgiye genellikle internetten ulaştıklarını, ilgilerine yönelik kurslar açıldığında halk eğitim merkezi kurslarına katılabileceklerini ifade etmişlerdir.
DETEKSI DINI CEGAH STUNTING (“ DENI CHETING”) PADA BALITA DI POSYANDU KRAJAN II
Authors: Pitayanti Asrina , Mulyati Sesaria Betty , Umam Faqih Nafiul 
Published: July 2022

Masa tumbuh kembang balita disebut golden period dimana otak berkembang dengan pesat. Apabila berat badan terus menurun maka timbul permasalahan stunting. Dampak stunting adalah terhambatnya kemampuan kognitif, psikomotorik, lebih rentan kena penyakit degenerative dan kualitas sumber daya manusia yang kurang berkualitas.. Pentingnya Investasi pencegahan stunting perlu dilakukan dengan upaya jemput bola melalui upaya deteksi dini cegah stunting (Deni Cheting) pada balita diposyandu untuk memastikan SDM Indonesia di masa yang akan datang berkualitas dan memiliki daya saing tinggi. Daerah tempat untuk pengabdian masyarakat termasuk lokus dengan kriteria jumlah balita cukup banyak dan belum melakukan identifikasi dan juga validasi data balita dengan stunting. Tujuan penmas ini mengidentifikasi balita yang mengalami masalah gizi (stunting, wasting, underweight) sehingga dapat membantu meningkatkan status gizi balita dan menemukan sumber masalah stunting. Pengukuran status gizi balita dengan pengukuran berat badan dan tinggi badan anak mengunakan aplikasi antropometri yaitu memasukan hasil pengukuran dengan urut Satu persatu kedalam system sehingga akan keluar hasil Z skor status gizi balita. Hasil kegiatan Kegiatan ini dihadiri oleh 67 balita posyandu krajan II. Diperoleh data balita dengan status gizi baik 58 balita (86, 56%), status gizi lebih 3 balita (4,47%), sedangkan kategori status kurang 5 balita ( 7,46%), dan kategori gizi buruk 1 balita (1,49%). Pentingnya Upaya Deteksi Dini Cegah Stunting (Deni Cheting) dapat membantu meningkatkan status gizi balita stunting dan menemukan sumber masalahnya
PENGARUH JENIS KELAMIN BALITA, USIA BALITA, STATUS KELUARGA DAN PENDAPATAN KELUARGA TERHADAP KEJADIAN PENDEK (STUNTED) PADA BALITA DI KOTA MOJOKERTO
Authors: Kurniawati Novi , Yulianto Yulianto 
Published: July 2022

Penanggulangan kejadian pendek (stunted) merupakan salah satu target capaian dalam SGDs 2030 yaitu pilar sosial dengan target capaian menghilangkan kelaparan dan menjamin akses bagi semua orang, khususnya orang miskin dan mereka yang berada dalam kondisi rentan, termasuk bayi, terhadap makanan yang aman, bergizi, dan cukup sepanjang tahun. Salah satu indikator target SGDs 2030 ini adalah menurunnya prevalensi kejadian stunting yang dialami balita di Indonesia. Seiring dengan hal tersebut, peningkatan status gizi masyarakat termasuk penurunan prevalensi balita pendek menjadi salah satu upaya prioritas pembangunan nasional yang tercantum di dalam sasaran pokok RJPM. Beberapa faktor yang diidentifikasi berpengaruh terhadap kejadian balita pendek (stunted) adalah jenis kelamin balita, usia balita, status keluarga dan pendapatan keluarga. Desain penelitian yang digunakan adalah studi kohort retrospektif dengan pendekatan cross sectional. Teknik sampling yang digunakan adalah nonprobability sampling dengan jenis purposive sampling. Sampel dalam penelitian ini adalah sebagian balita di posyandu Balongrawe Kelurahan Kedundung Kecamatan Magersari Kota Mojokerto yang memenuhi kriteria penelitian sebanyak 56 responden. Variabel yang dilakukan kajian penelitian adalah status gizi balita (kejadian pendek / stunted), jenis kelamin balita, usia balita status keluarga dan pendapatan keluarga. Uji analisa data menggunakan regresi binary logistic dengan signifikansi α (0,05). Dari hasil uji regresi binary logistik didapatkan faktor dominan yang berpengaruh terhadap kejadian pendek (stunted) pada balita di Kota Mojokerto adalah status keluarga balita dengan nilai p value sebesar 0,019 < α (0,05) maka dapat disimpulkan bahwa status keluarga memberikan pengaruh parsial yang signifikan terhadap kejadian pendek (stunted) pada balita di Kota Mojokerto
FUNCTIONALITY BETWEEN ECONOMIC INDICATORS AND DEBT CRISIS OF AN ECONOMY: A CAUSAL STUDY ON PAKISTAN’S ECONOMY (2002-2017)
Authors: Naeem Mahpara , Rafiq Tariq 
Published: July 2022

The economy of Pakistan has been facing depressed economic conditions for several years since many years. Debt to GDP has marked its peaks of Rs 21408.7 billion in 2017. The state of Pakistan has taken measures to reduce it. Various economic policies with amendments are being introduced by state authorities to make the favorable economic conditions but still, there are some factors that are creating economic instability in Pakistan such as an increase in Public Debt Burden is one of them. So, this study primarily focuses on the exploration of a causal relationship between public debt and economic indicators of Pakistan. Secondarily it focuses on analyzing the relationship between public debt and economic indicators such as market capitalization, reserves, exchange rate, and fiscal deficits. The study has employed both type analysis qualitative and quantitative. Quantitative data is analyzed through statistical software EVIEWS. 16 years of data of Public Debt and economic indicators of Pakistan from 2002 to 2017 has been analyzed. Standardized criteria were adopted to accept or reject the hypothesis. Based on inferences, policies and implications are given in the shape of recommendations for corrective measures.
Prognostic Communication in the Era of Targeted Therapy and Immunotherapy
Authors: Cervantez Sherri , Butler Matthew , Karnad Anand 
Published: July 2022

Effectively communicating prognosis to patients with cancer is a key communication task for physicians. It has always been a difficult task and is now becoming more so. Rapid progress in treatment of advanced cancers is transforming a previously terminal illness with its proverbial <6 months of life expectancy into a chronic illness with years of meaningful quality of life ahead. Despite this evolution, the importance of communicating prognosis to enable shared decision-making cannot change. Communication skills for this specific task should be strengthened and refined with practice and toolkits to enable physicians to rise to the unique challenge of discussing prognosis in this rapidly shifting milieu of cancer care. This chapter will first discuss how targeted and immunotherapy have changed the landscape of cancer therapy and complicated prognostication through representative case examples. Secondly, we will outline communication preferences, barriers to prognostication, and tools useful in cancer prognostication. Finally, we will identify techniques palliative physicians and oncologists utilize to convey prognostic information vital to patient decision-making.
Topomineralogía de la província de Ávila 2
Authors: Mata Perelló Josep Maria , Sanz Balagué Joaquim 
Published: July 2022

Con este número, seguiremos con el tratamiento de la TOPOMINERALOGIA ABULENSE: o lo que es lo mismo: LOS MINERALES Y SUS YACIMIENTOS EN LA PROVÍNCIA DE ÁVILA.
Así, esta TOPOMINERALOGIA ABULENSE, la estamos presentando en cuatro números sucesivos de esta publicación. De esta forma, en este segundo número (CANTIL 009), nos centraremos en uno de los antiguos Partidos Judiciales de la provincia de Ávila, concretamente en el de la capital.
En el siguiente número de la serie (CANTIL 010) nos centraremos en los de Barco de Ávila y Cebreros. Finalmente, en el cuarto de los números dedicados a esta provincia (CANTIL 011), nos dedicaremos exclusivamente al de Piedrahita. Por otra parte, al final de este último, publicaremos un índice general de las localidades citadas en la Provincia de Ávila.
En cada caso, en la FICHA EXCEL (elaborada por Antonieta SANTACREU), daremos los siguientes daros de cada indicio:
- MUNICIPIO. A menudo indicaremos el agregado (en este caso, con el nombre del municipio, entre paréntesis)
- PARAJE (con las coordenadas UTM X e Y y a menudo la Z)
- CARACTERÍSTICAS
- Nª DEL MAPA EN QUE SE HALLA (a escala 1:50.000)
- MINERALES ENCONTRADOS
Evidentemente, podríamos ”vestir” estos datos con más detalles, pero en aras a la efectividad, nos hemos decantado por la sencillez de esta exposición de los datos otrora obtenidos y revisados a menudo en el campo, tras sucesivas investigaciones sobre el terreno.
Is platelet-lymphocyte ratio (PLR) a predictor of thrombosis and together with circulating tumor cells capable to determine recurrence-free survival in patients with gastric cancer?
Authors: Pignataro Bruno Soriano , Abdallah Emne Ali , Mello Celso Abdon Lopes , Calsavara Vinicius Fernando , Nishinari Kenji , Ruano Anna Paula Carreta , Fanelli Marcello F , Yazbek Guilherme , Chinen Ludmilla Thomé Domingos 
Published: July 2022

ABSTRACT
Introduction: Cancer-associated thrombosis (CAT) is a major cause of morbidity and mortality in oncology patients. There are no accurate risk assessment tools to predict venous thromboembolism (VTE). Circulating tumor cells (CTCs), circulating tumor microemboli (CTM), and high platelet-lymphocyte ratio (PLR) may predispose to VTE.
Objective: To evaluate correlations of CTCs, CTM, and PLR with VTE and recurrence-free survival (RFS) in gastric cancer patients.
Material and Methods: Patients with gastric cancer (localized and metastatic disease) were recruited (March 2016 to April 2017). CTCs were analysed by ISET at two timepoints: before neoadjuvant treatment (CTC1) and after surgery/before adjuvant therapy (CTC2) for patients with localized disease, and before first-line chemotherapy (CTC1) and after 6 months (CTC2) for patients with metastases. VTE incidence was determined retrospectively. RFS was estimated by Kaplan-Meier analysis.
Results: We evaluated 93 patients. According to Khorana scores, 63 (67.7%) patients were at intermediate and 30 (32.3%) were at high risk for VTE. VTE incidence was 20.4% and CTM were found in 39.8%. VTE developed in 7/37 (18.9%) CTM-positive and in 11/50 (22%) CTM-negative patients (p=0.93). When PLR >288, VTE occurred in 7/14 patients (p=0.005). PLR also associated with poor RFS (p<0.0001). CTC2 was associated with poor RFS (p<0.0001). CTC2, PLR and VTE were independent prognostic factors for RFS (p=0.005, 0.043, and <0.0001, respectively).
Conclusion: PLR is a prognostic indicator for VTE and RFS in gastric cancer patients. Neither CTC, nor CTM improved risk stratification for VTE in our studied population. PLR, CTC2, and VTE were independent prognostic factors for RFS.