bluuebunny/crossref_metadata_2025_split huggingface dataset:
Home-based, supervised, and mixed exercise intervention on functional capacity and quality of life of colorectal cancer patients: a meta-analysis
Authors: Kraemer Mauricio Beitia , Priolli Denise Gonçalves , Reis Ivan Gustavo Masseli , Pelosi Andrea Corazzi , Garbuio Ana Luíza Paula , Messias Leonardo Henrique Dalcheco 
Published: February 2022

AbstractThis systematic review and meta-analysis of randomized controlled trials tested the effects of home-based, supervised, or mixed exercise interventions on the functional capacity (FC) and quality of life (QoL) in colorectal cancer patients. A literature search was performed using the PubMed, Embase, Cochrane, and Medline databases. Two reviewers screened the literature through March 10, 2021 for studies related to exercise and colorectal cancer. Of the 1161 screened studies in the initial search, 13 studies met the eligibility criteria (home-based = 6 studies; supervised or mixed = 7 studies). Overall, 706 patients were enrolled in the trials, and 372 patients were submitted to home-based, supervised, or mixed exercise intervention. The overall results from the main meta-analysis showed a significant effect regarding supervised or mixed intervention (6 studies; p = 0.002; I2 = 43%; PI 0.41–1.39); however, no significant effect was observed for home-based intervention (5 studies; p = 0.05; I2 = 25%; PI − 0.34–0.76). A sensitivity analysis based on studies with intervention adherence ≥ 80% (home-based = 3 studies; supervised or mixed = 4 studies) revealed that home-based intervention or intervention entirely supervised or with some level of supervision (mixed) are effective in improving the QoL and FC of CRC patients. In summary, this meta-analysis verified that supervised and home-based exercise can modify QoL and FC when intervention adherence ≥ 80%. Regardless of the supervision characteristics, future RCTs are strongly encouraged to provide a detailed description of the exercise variables in physical interventions for CRC prescription. This perspective will allow a refined exercise prescription for patients with CRC, mainly according to their clinical status.
Early heart rate variability evaluation enables to predict ICU patients’ outcome
Authors: Bodenes Laetitia , N’Guyen Quang-Thang , Le Mao Raphaël , Ferrière Nicolas , Pateau Victoire , Lellouche François , L’Her Erwan 
Published: February 2022

AbstractHeart rate variability (HRV) is a mean to evaluate cardiac effects of autonomic nervous system activity, and a relation between HRV and outcome has been proposed in various types of patients. We attempted to evaluate the best determinants of such variation in survival prediction using a physiological data-warehousing program. Plethysmogram tracings (PPG) were recorded at 75 Hz from the standard monitoring system, for a 2 h period, during the 24 h following ICU admission. Physiological data recording was associated with metadata collection. HRV was derived from PPG in either the temporal and non-linear domains. 540 consecutive patients were recorded. A lower LF/HF, SD2/SD1 ratios and Shannon entropy values on admission were associated with a higher ICU mortality. SpO2/FiO2 ratio and HRV parameters (LF/HF and Shannon entropy) were independent correlated with mortality in the multivariate analysis. Machine-learning using neural network (kNN) enabled to determine a simple decision tree combining the three best determinants (SDNN, Shannon Entropy, SD2/SD1 ratio) of a composite outcome index. HRV measured on admission enables to predict outcome in the ICU or at Day-28, independently of the admission diagnosis, treatment and mechanical ventilation requirement.Trial registration: ClinicalTrials.gov identifier NCT02893462.
Mechanical and optimization studies of polypropylene hybrid biocomposites
Authors: Adediran Adeolu A. , Akinwande Abayomi A. , Balogun Oluwatosin A. , Bello Oladele S. , Akinbowale Miracle K. , Adesina Olanrewaju S. , Ojo Ayotunde A. 
Published: February 2022

AbstractTowards developing a polymeric matrix characterized by high strength to cost ratio, polypropylene (PP) was hybridized with low-cost particulate snail shell (PSS) and kenaf fiber (KF) via compression moulding at 180 °C and 0.2 MPa. The developed composites were grouped into three and labeled as mix 2, 4, and 10. Each group entailed the blend of 5, 10, 20, and 30 wt% KF with 2, 4, 10 wt% PSS respectively. From the results, it is observed that the hardness value was enhanced by the blend of 5 to 30 wt% KF and 2, 4, and 10 wt% PSS. However, 2 wt% PSS mix with 5 to 30 wt% KF resulted in progressive improvement in impact, compressive, flexural, and tensile strengths values. The 4 wt% PSS yielded consecutive increase in impact, compressive and flexural strength when combined with 5 and 10 wt% KF. However, it was observed that subsequent addition of 20 and 30 wt% KF led to a marginal reduction in the strength values. The tensile strength attained optimum value when 4 wt% PSS was commixed with 30 wt% KF. Conversely, the combinations of 10 wt% PSS with 5, 10, 20, and 30 wt% KF had no significant improvement to the mechanical properties of PSS/KF-bio-PP composite (except for hardness) siring strength decrease. Taguchi optimization revealed that the collage of 4 wt% PSS and 10 wt% KF presented optimum mix for hybrid bio-PP composite.
An improved farmland fertility algorithm for many-objective optimization problems
Authors: Wang Yanjiao , Gao Peng , Chen Ye 
Published: February 2022

AbstractRecent studies on many-objective optimization problems (MaOPs) have tended to employ some promising evolutionary algorithms with excellent convergence accuracy and speed. However, difficulties in scalability upon MaOPs including the selection of leaders, etc., are encountered because the most evolutionary algorithms are proposed for single-objective optimization. To further improve the performance of many-objective evolutionary algorithms in solving MaOPs when the number of the objectives increases, this paper proposes a many-objective optimization algorithm based on the improved Farmland Fertility algorithm (MOIFF). In MOIFF, a novel bio-inspired meta heuristic method proposed in 2018, called Farmland Fertility algorithm (FF), is employed to serve as the optimization strategy. In order to handle MaOPs effectively, FF has been tailored from the following aspects. An individual fitness assessment approach based on cumulative ranking value has been proposed to distinguish the quality of each individual; a novel method based on individual cumulative ranking value to constitute and update the global memory and local memory of each individual is proposed, and a hybrid subspace search and full space search method has been designed to update individuals in the stages of soil optimization and soil fusion. In addition, adaptive environmental selection has been proposed. Finally, MOIFF is compared with four state-of-the art many-objective evolutionary algorithms on many test problems with various characteristics, including the DTLZ and WFG test suites. Experimental results demonstrate that the proposed algorithm has competitive convergence and diversity on MaOPs.
Multi-modal 3D imaging of radionuclides using multiple hybrid Compton cameras
Authors: Omata Akihisa , Masubuchi Miho , Koshikawa Nanase , Kataoka Jun , Kato Hiroki , Toyoshima Atsushi , Teramoto Takahiro , Ooe Kazuhiro , Liu Yuwei , Matsunaga Keiko , Kamiya Takashi , Watabe Tadashi , Shimosegawa Eku , Hatazawa Jun 
Published: February 2022

AbstractFor radiological diagnosis and radionuclide therapy, X-ray and gamma-ray imaging technologies are essential. Single-photon emission tomography (SPECT) and positron emission tomography (PET) play essential roles in radiological diagnosis, such as the early detection of tumors. Radionuclide therapy is also rapidly developing with the use of these modalities. Nevertheless, a limited number of radioactive tracers are imaged owing to the limitations of the imaging devices. In a previous study, we developed a hybrid Compton camera that conducts simultaneous Compton and pinhole imaging within a single system. In this study, we developed a system that simultaneously realizes three modalities: Compton, pinhole, and PET imaging in 3D space using multiple hybrid Compton cameras. We achieved the simultaneous imaging of Cs-137 (Compton mode targeting 662 keV), Na-22 (PET mode targeting 511 keV), and Am-241 (pinhole mode targeting 60 keV) within the same field of view. In addition, the imaging of Ga-67 and In-111, which are used in various diagnostic scenarios, was conducted. We also verified that the 3D distribution of the At-211 tracer inside a mouse could be imaged using the pinhole mode.
Parametric simulation of micropolar fluid with thermal radiation across a porous stretching surface
Authors: Bilal Muhammad , Saeed Anwar , Gul Taza , Kumam Wiyada , Mukhtar Safyan , Kumam Poom 
Published: February 2022

AbstractThe energy transmission through micropolar fluid have a broad range implementation in the field of electronics, textiles, spacecraft, power generation and nuclear power plants. Thermal radiation's influence on an incompressible thermo-convective flow of micropolar fluid across a permeable extensible sheet with energy and mass transition is reported in the present study. The governing equations consist of Navier–Stokes equation, micro rotation, temperature and concentration equations have been modeled in the form of the system of Partial Differential Equations. The system of basic equations is reduced into a nonlinear system of coupled ODE's by using a similarity framework. The numerical solution of the problem has been obtained via PCM (Parametric Continuation Method). The findings are compared to a MATLAB built-in package called bvp4c to ensure that the scheme is valid. It has been perceived that both the results are in best agreement with each other. The effects of associated parameters on the dimensionless velocity, micro-rotation, energy and mass profiles are discussed and depicted graphically. It has been detected that the permeability parameter gives rise in micro-rotation profile.
Genome editing with removable TALEN vectors harboring a yeast centromere and autonomous replication sequence in oleaginous microalga
Authors: Kurita Tomokazu , Iwai Masako , Moroi Keishi , Okazaki Kumiko , Nomura Seiji , Saito Fumihiko , Maeda Shinichiro , Takami Akihide , Sakamoto Atsushi , Ohta Hiroyuki , Sakuma Tetsushi , Yamamoto Takashi 
Published: February 2022

AbstractAlgal lipids are expected to become a basis for sustainable fuels because of the highly efficient lipid production by photosynthesis accompanied by carbon dioxide assimilation. Molecular breeding of microalgae has been studied to improve algal lipid production, but the resultant gene-modified algae containing transgenes are rarely used for outdoor culture because the use of genetically modified organisms (GMOs) is strictly restricted under biocontainment regulations. Recently, it was reported that plasmids containing yeast centromere and autonomous replication sequence (CEN/ARS) behaved as episomes in Nannochloropsis species. We previously reported that the Platinum TALEN (PtTALEN) system exhibited high activity in Nannochloropsis oceanica. Therefore, we attempted to develop a genome editing system in which the expression vectors for PtTALEN can be removed from host cells after introduction of mutations. Using all-in-one PtTALEN plasmids containing CEN/ARS, targeted mutations and removal of all-in-one vectors were observed in N. oceanica, suggesting that our all-in-one PtTALEN vectors enable the construction of mutated N. oceanica without any transgenes. This system will be a feasible method for constructing non-GMO high-performance algae.
The metabolomics profile of growth rate in grazing beef cattle
Authors: Imaz José Augusto , García Sergio , González Luciano Adrián 
Published: February 2022

AbstractThis study aimed to determine the relationship between the metabolome and changes in growth rate (i.e., liveweight change, LWC) and molasses-lick block supplement intake (MLB) of grazing cattle. Weaner beef cattle were fed for 220 days with a sequence of feed types and blood samples, growth rate, and supplement intake were taken on five points in time. The relative abundance (RA) of plasma metabolites were determined using proton nuclear magnetic resonance (NMR). Sixty-four per cent of the metabolites identified were associated with LWC but only 26% with MLB intake (P < 0.05). Periods with faster growth rate showed high availability of amino acids (i.e., valine, leucine, isoleucine, phenylalanine and tyrosine), acetate, and 3-hydroxybutyrate. Periods with lower growth rate were associated with high RA of lipids, choline and acetate. The metabolic profile of individual animals during a period of compensatory growth (after periods of poor performance) showed that high-performing animals were characterised by lower RA of amino acids (i.e., valine, leucine, isoleucine, methylhistidine), creatinine, creatine, pyruvate, 3-hydroxybutyrate, and acetyl groups. It is speculated that high-performing animals have faster uptake of these metabolites from the bloodstream. Cattle growth rate over time was associated with their metabolome which could be used to ensure that the availability of certain metabolites promoting growth is tailored in feed supplements to improve production.
Noble metal alloy thin films by atomic layer deposition and rapid Joule heating
Authors: Guo Yuanyuan , Zou Yiming , Cheng Chunyu , Wang Leyan , Made Riko I , Goei Ronn , Tan Kwan Wee , Li Shuzhou , Tok Alfred Iing Yoong 
Published: February 2022

AbstractMetal alloys are usually fabricated by melting constituent metals together or sintering metal alloy particles made by high energy ball milling (mechanical alloying). All these methods only allow for bulk alloys to be formed. This manuscript details a new method of fabricating Rhodium–Iridium (Rh–Ir) metal alloy films using atomic layer deposition (ALD) and rapid Joule heating induced alloying that gives functional thin film alloys, enabling conformal thin films with high aspect ratios on 3D nanostructured substrate. In this work, ALD was used to deposit Rh thin film on an Al2O3 substrate, followed by an Ir overlayer on top of the Rh film. The multilayered structure was then alloyed/sintered using rapid Joule heating. We can precisely control the thickness of the resultant alloy films down to the atomic scale. The Rh–Ir alloy thin films were characterized using scanning and transmission electron microscopy (SEM/TEM) and energy dispersive spectroscopy (EDS) to study their microstructural characteristics which showed the morphology difference before and after rapid Joule heating and confirmed the interdiffusion between Rh and Ir during rapid Joule heating. The diffraction peak shift was observed by Grazing-incidence X-ray diffraction (GIXRD) indicating the formation of Rh–Ir thin film alloys after rapid Joule heating. X-ray photoelectron spectroscopy (XPS) was also carried out and implied the formation of Rh–Ir alloy. Molecular dynamics simulation experiments of Rh–Ir alloys using Large-Scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) were performed to elucidate the alloying mechanism during the rapid heating process, corroborating the experimental results.
Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux
Authors: Dotan Idit , Yang Jiaqi , Ikeda Jiro , Roth Ziv , Pollock-Tahiri Evan , Desai Harsh , Sivasubramaniyam Tharini , Rehal Sonia , Rapps Josh , Li Yu Zhe , Le Helen , Farber Gedaliah , Alchami Edouard , Xiao Changting , Karim Saraf , Gronda Marcela , Saikali Michael F. , Tirosh Amit , Wagner Kay-Uwe , Genest Jacques , Schimmer Aaron D. , Gupta Vikas , Minden Mark D. , Cummins Carolyn L. , Lewis Gary F. , Robbins Clinton , Jongstra-Bilen Jenny , Cybulsky Myron , Woo Minna 
Published: February 2022

AbstractAtherosclerosis is a chronic inflammatory condition in which macrophages play a major role. Janus kinase 2 (JAK2) is a pivotal molecule in inflammatory and metabolic signaling, and Jak2V617F activating mutation has recently been implicated with enhancing clonal hematopoiesis and atherosclerosis. To determine the essential in vivo role of macrophage (M)-Jak2 in atherosclerosis, we generate atherosclerosis-prone ApoE-null mice deficient in M-Jak2. Contrary to our expectation, these mice exhibit increased plaque burden with no differences in macrophage proliferation, recruitment or bone marrow clonal expansion. Notably, M-Jak2-deficient bone marrow derived macrophages show a significant defect in cholesterol efflux. Pharmacologic JAK2 inhibition with ruxolitinib also leads to defects in cholesterol efflux and accelerates atherosclerosis. Liver X receptor agonist abolishes the efflux defect and attenuates the accelerated atherosclerosis that occurs with M-Jak2 deficiency. Macrophages of individuals with the Jak2V617F mutation show increased efflux which is normalized when treated with a JAK2 inhibitor. Together, M-Jak2-deficiency leads to accelerated atherosclerosis primarily through defects in cholesterol efflux from macrophages.
Synthesis of Cu-doped 2D-WS2nanosheet-based nano-antibiotic materials for inhibitingE. ColiandS. aureusbacterial strains
Authors: Ashfaq Mohammad , Talreja Neetu , Chauhan Divya , Viswanathan Mangalaraja Ramalinga 
Published: February 2022

A new class of nano-antibiotic materials must be developed to treat bacterial infectious diseases. In this context, the synthesizing Cu-metal incorporated WS2 nanosheet (Cu–WS2-NS)-based antibiotic materials might overcome such associated issues.
A current‐limiting DC circuit breaker with power flow control capability
Authors: Xue Shimin , Chen Xiao , Liu Baibing , Chen Wenjie , Li Botong , Li Bin 
Published: February 2022

AbstractPower flow controller (PFC), fault current limiter (FCL) and DC circuit breaker (DCCB) are important equipment in the DC grid. There are a large number of power electronic components in these equipment, resulting in high cost. In order to reduce the use of additional components, a current‐limiting DC circuit breaker with power flow control capability is proposed here, which integrates the PFC, FCL, and DCCB into one equipment. Further, the main breaker in the proposed circuit breaker is shared by all lines connected to a DC bus to reduce cost. The topology and operating principle of the circuit breaker are introduced. Theoretical analysis and parameter design are carried out. Besides, the proposed circuit breaker is verified in PSCAD/EMTDC. Finally, the performance and cost are compared with existing schemes. The simulation results show that the proposed circuit breaker can effectively realize power flow control, current limiting and fault isolation at a lower cost.
Enlarging flexibility region of virtual power plant via dynamic line rating
Authors: Tan Zhenfei , Wang Siyu , Zhong Haiwang , Xia Qing , Kang Chongqing 
Published: February 2022

AbstractThe virtual power plant (VPP) can aggregate small‐scale distributed resources to provide flexibility for the transmission system. The flexibility provision capability of the VPP is restricted by technical operating limits of the distribution system to which distributed resources are connected. To facilitate the flexibility provision of the VPP while securing the operation of the local system, this paper leverages the dynamic line rating (DLR) to enlarge the VPP flexibility region. The flexibility region of the VPP is defined as the allowable range of active and reactive power output that the VPP can execute subject to operating constraints of the internal system. With the DLR, the current carrying capacity of the distribution network is dynamically adjusted based on actual environmental conditions, which helps to remove barriers from transmission limits that hinder the integration of distributed flexibility. A convex hull‐based method with an explicit accuracy guarantee is proposed to approximate the flexibility region with the DLR. Case studies based on IEEE‐33 and IEEE‐123 test feeders with real‐world operation data validate the proposed framework.
A new double‐market parallel trading mechanism for competitive electricity markets
Authors: Shang Jingyi , Jiang Xin , Gao Jinfeng , Fu Keyuan , Wen Fushuan 
Published: February 2022

AbstractThe current electricity market trading mechanism mainly includes the bilateral negotiation transaction and centralized transaction, with defects such as information asymmetry, insufficient competition, and weak price discovery. Thus, a new double‐market parallel trading mechanism is proposed to improve the efficiency of the competitive electricity market in this paper. Regard the electricity market as a price‐searching market and divide into two sub‐markets composed of a price‐searching market for buyers and a price‐searching market for sellers. Market entities can trade synchronously in two sub‐markets as price searchers or bidders. Searchers are responsible for organizing transactions in line with the market clearing rule library, and bidders participate in transactions initiated by searchers. Under the parallel mechanism, the traditional trading mechanism is also applicable. the framework of the proposed mechanism is presented from four aspects, including the description, clearing process, operation mode, and linkage between two sub‐markets. Then, a market clearing model of the proposed mechanism is built with several traditional transaction modes as special cases of the presented double‐market parallel transactions. Finally, taking the centralized transaction as an example, results show that the proposed mechanism can effectively provide market entities more chances to win contracts, and enhance the market liquidity.
Coherence‐based automatic power factor correction (APFC) algorithm for power grids
Authors: Mahmoud Ragab Abd Allah , Emam Ahmed 
Published: February 2022

AbstractA power factor correction (PFC) plays a major role towards the improvement of power systems quality and stability, as well as protection and control systems performance. This paper presents a novel method for automatic power factor correction (APFC) based on the coherence approach. In this method, the original power factor and the required reactive power compensation can be determined using the cross‐coherence coefficients evaluated between voltage and current signals. Beside auto‐coherence coefficients are useful for detecting the fault/unbalance conditions in power systems. The proposed algorithm prevents the PFC process in the events of over‐compensation and abnormal events. In addition, new proposed operating characteristics for PFC, based on the coherence coefficient limits, are developed. Extensive simulation results of the proposed method are included and its accuracy and feasibility can be verified. Compared with the conventional PFC, the coherence‐based PFC is easy to control, and the power factor is nearer to unity can be obtained, where its performance accuracy is greater than 99.4%. The proposed method is characterized by being simple, fast and reliable, and it can be implemented practically. Its sensitivity and security is controllable via selecting coherence setting values.