bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flexible and highly‐sensitive pressure sensor based on controllably oxidized MXene
Authors: Ma Yanan , Cheng Yongfa , Wang Jian , Fu Si , Zhou Mengjun , Yang Yue , Li Baowen , Zhang Xin , Nan Ce‐Wen 
Published: June 2022

AbstractConductive Ti3C2Tx MXenes have been widely investigated for the construction of flexible and highly‐sensitive pressure sensors. Although the inevitable oxidation of solution‐processed MXene has been recognized, the effect of the irreversible oxidation of MXene on its electrical conductivity and sensing properties is yet to be understood. Herein, we construct a highly‐sensitive and degradable piezoresistive pressure sensor by coating Ti3C2Tx MXene flakes with different degrees of in situ oxidation onto paper substrates using the dipping‐drying method. In situ oxidation can tune the intrinsic resistance and expand the interlayer distance of MXene nanosheets. The partially oxidized MXene‐based piezoresistive pressure sensor exhibits a high sensitivity of 28.43 kPa−1, which is greater than those of pristine MXene, over‐oxidized MXene, and state‐of‐the‐art paper‐based pressure sensors. Additionally, these sensors exhibit a short response time of 98.3 ms, good durability over 5000 measurement cycles, and a low force detection limit of 0.8 Pa. Moreover, MXene‐based sensing elements are easily degraded and environmentally friendly. The MXene‐based pressure sensor shows promise for practical applications in tracking body movements, sports coaching, remote health monitoring, and human–computer interactions.
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Market operating leverage and expected stock returns
Authors: Taussig Roi D. 
Published: June 2022

AbstractThis article's main goal is to analyze the impact of market operating leverage (OL) on expected stock returns. While OL has been analyzed substantially in the literature, the analysis of an aggregate measure is new. The article begins with a cross‐section analysis of 184,280 firm‐year US firms, after which a former literature analysis is confirmed with current data. Next, an Aggregate Operating Leverage (AOL) is constructed. AOL predicts market returns both in and out of sample. Moreover, AOL significantly predicts the S&P500 Index, which is also of great consequence to practitioners.
A bifunctional carbon catalyst with Cl and SO3H groups for hydrolyzing furfural residue to levulinic acid
Authors: Zhang Shuaibin , Yan Bochao , Chen Zhihui , Zhang Suping 
Published: June 2022

AbstractBACKGROUNDLevulinic acid, an important platform compound, is extensively used in textiles, dyes, antifreeze, animal feed, solvents and food additives. However, the use of lignocellulosic biomass to produce levulinic acid is difficult because of poor accessibility to cellulose and low hydrolytic yield. Thus a viable hydrolysis strategy and a suitable catalyst must be developed.RESULTSIn this study, a bifunctional solid acid catalyst (HTC‐SO3H) containing both cellulose binding sites (Cl, COOH and OH) and catalytic sites (SO3H) was prepared by a carbonization–grafting–oxidization method. X‐ray photoelectron spectroscopy and Fourier transform infrared characterization confirmed the existence of Cl and the successful modification of the SO3H grafted hydrothermal carbon. The hydrogen bonds formed between cellulose and the binding sites (Cl, OH and COOH) in the catalyst showed synergistic effects with the catalytic sites (SO3H), leading to efficient hydrolysis of the furfural residue. A total of 74.81% (non‐magnetic) and 70.18% (magnetic) levulinic acid yields were obtained after hydrolysis at 190 °C and 180 min in γ‐valerolactone–H2O (1:1, v/v). Magnetic catalysts were synthesized using a co‐precipitation method. Catalysts were recycled without any obvious reduction in catalytic activity.CONCLUSIONUsing sucralose as a raw material, the as‐synthesized bifunctional solid acid catalyst improved the accessibility to cellulose and increased levulinic acid yield. Moreover, the grafted SO3H formed by hydroxyl hydration condensation exhibited superior stability. This study provides a valuable strategy for the efficient hydrolysis of lignocellulosic biomass. © 2022 Society of Chemical Industry (SCI).
A comparison of soil Staphylococcus aureus and fecal indicator bacteria concentrations across land uses in a Hawaiian watershed
Authors: Gerken Tyler , Wiegner Tracy N. , Economy Louise M. 
Published: June 2022

AbstractStaphylococcus aureus, methicillin‐resistant S. aureus (MRSA), and fecal indicator bacteria (FIB; Enterococcus spp., Clostridium perfringens) concentrations increase in Hawaiian streams and estuaries following storms and pose a health threat to recreational water users. To reduce this risk, watershed bacteria sources need to be identified for management actions. This study's goals were to identify soil bacteria sources among different land uses and to determine if their concentrations were associated with different soil properties. Soil samples were collected three times on 24 d between October 2017 and November 2018 at urban, agriculture, and native‐forest land uses in the Hilo Bay watershed, Hawaiʻi Island, Hawaiʻi. Soil bacteria concentrations were quantified using culturing techniques with selective media. Staphylococcus aureus, MRSA, and FIB were present in soil from all land uses. Bacteria concentrations were highest in urban soils and lowest in native‐forest soils, with up to three orders of magnitude differences among land uses. Staphylococcus aureus, MRSA, and FIB soil concentrations were positively correlated with each other and with soil temperature and pH, but inversely correlated with soil moisture and organic matter content. Our results demonstrate that soils are a watershed bacteria source and that some soil properties affect their concentrations. Identifying these sources is critical for implementing management actions to reduce pathogen loads to estuaries and transmission to recreational water users.
多彩な免疫再構築症候群の症状を呈した重症COVID–19の1例(Various IRIS–like symptoms following severe COVID–19 infection: a case report)
Authors: (Yusuke Minagawa) 皆川 裕祐 , (Yoshihiro Hagiwara) 萩原 祥弘 , (Ayami Sato) 佐藤 綾美 , (Wataru Kasahara) 笠原 道 , (Takaomi Kobayashi) 小林 孝臣 , (Kensuke Fujita) 藤田 健亮 , (Takayuki Ogura) 小倉 崇以 
Published: June 2022

要旨薬剤性過敏症症候群（drug reaction with eosinophilia and systemic symptoms: DRESS）は，臓器障害を伴う重症薬疹の一つであり発生機序において免疫再構築症候群（immune reconstitution inflammatory syndrome: IRIS）の病態が関与していると考えられている。今回我々は，新型コロナウイルス感染症（coronavirus disease 2019: COVID–19）による重症肺炎の治療過程においてDRESSをIRISの一病態として発症したと考えられる一症例を報告する。症例は56歳の男性。重症COVID–19の治療のために第1病日よりVV–ECMO管理を行った。人工呼吸器関連肺炎を来し第3～6病日にメロペネムを使用した。その後も多剤耐性緑膿菌による肺膿瘍やEnterobacter cloacae菌血症を来したが，約1か月でVV–ECMOを離脱した。その後第37病日に播種状紅斑丘疹型の皮疹を呈し，発熱・頻脈・血圧低下・急性腎障害を来しRegiSCARの基準からDRESSと診断された。DRESSの被疑薬として薬剤リンパ球刺激試験の結果からメロペネムを疑った。ステロイド投与を開始し血行動態は安定し，皮疹や腎障害も改善したがステロイドの漸減開始後に汎発性帯状疱疹・Ramsay–Hunt症候群を続けて合併したため再度ステロイドを増量し症状は寛解に向かった。一連の経過より重症COVID–19の回復期にIRISの一病態として発症したDRESSおよびVZVの再活性化と考えられた。重症COVID–19の回復期においては，IRISの病態の存在を念頭に，ステロイドの適切な使用とその後の慎重な減量を行うことが望ましいと考えられた。
Treatment failure patterns are similar between p16− and p16+ oropharyngeal squamous cell carcinomas
Authors: Hamill Chelsea S. , Muller Richard Grant , Clancy Kate , Vu Brandon , Gui Shanying , Thuener Jason Eric , Wasman Jay , Li Shawn , Fowler Nicole , Rezaee Rod , Lavertu Pierre , Teknos Theodoros N. , Pan Quintin , O'Neill Wendi Quinn 
Published: June 2022

AbstractBackgroundThe incidence of p16+ oropharyngeal squamous cell carcinoma (OPSCC) has been increasing. The notion that p16+ OPSCC has a propensity for atypical and disseminating metastasis has gained traction. We compared treatment failure patterns in p16+ and p16− OPSCC and evaluated survival impact.MethodsRetrospective analysis of patients with recurrent/metastatic OPSCC disease between 1/2009 and 12/2019.ResultsThirty‐eight p16+ and 36 p16− patients were identified. Three distinct failure patterns (distant vs. locoregional, atypical vs. typical, and disseminating vs. non‐disseminating) were studied. No significant differences were found between p16+ and p16− patients. Multivariate analysis showed p16 status was an independent prognostic biomarker; p16+ patients have a favorable overall survival compared to p16− patients (HR 0.34, 95% CI 0.16–0.77; P = .005).ConclusionsWe challenge the view that p16+ OPSCC exhibits a distinctive treatment failure pattern and showed that p16 status impacts patient survival independent of disease progression.
Determination of adulteration, geographical origins, and species of food by mass spectrometry
Authors: Chien Han‐Ju , Zheng Yi‐Feng , Wang Wei‐Chen , Kuo Cheng‐Yu , Hsu Yu‐Ming , Lai Chien‐Chen 
Published: June 2022

AbstractFood adulteration, mislabeling, and fraud, are rising global issues. Therefore, a number of precise and reliable analytical instruments and approaches have been proposed to ensure the authenticity and accurate labeling of food and food products by confirming that the constituents of foodstuffs are of the kind and quality claimed by the seller and manufacturer. Traditional techniques (e.g., genomics‐based methods) are still in use; however, emerging approaches like mass spectrometry (MS)‐based technologies are being actively developed to supplement or supersede current methods for authentication of a variety of food commodities and products. This review provides a critical assessment of recent advances in food authentication, including MS‐based metabolomics, proteomics and other approaches.
Norcantharidin promotes cancer radiosensitization through Cullin1 neddylation‐mediated CDC6 protein degradation
Authors: Deng Tanggang , Zhu Qianling , Xie Lin , Liu Youhong , Peng Yuchong , Yin Linglong , Gao Yingxue , Cao Tuoyu , Fu Yuxin , Qi Xuli , Zhang Songwei , Peng Yongbo , Hou Youxiang , Li Xiong 
Published: June 2022

AbstractRadiotherapy (RT) is a conventional cancer therapeutic modality. However, cancer cells tend to develop radioresistance after a period of treatment. Diagnostic markers and therapeutic targets for radiosensitivity are severely lacking. Our recently published studies demonstrated that the cell division cycle (CDC6) is a critical molecule contributing to radioresistance, and maybe a potential therapeutic target to overcome radioresistance. In the present study, we for the first time reported that Norcantharidin (NCTD), a demethylated form of cantharidin, re‐sensitized radioresistant cancer cells to overcome radioresistance, and synergistically promoted irradiation (IR)‐induced cell killing and apoptosis by inducing CDC6 protein degradation. Mechanistically, NCTD induced CDC6 protein degradation through the ubiquitin‐proteasome pathways. By using small interfering RNA (siRNA) interference or small compound inhibitors, we further determined that NCTD induced CDC6 protein degradation through a neddylation‐dependent pathway, but not through Huwe1, Cyclin F, and APC/C‐mediated ubiquitin‐proteasome pathways. We screened the six most relevant Cullin subunits (CUL1, 2, 3, 4A, 4B, and 5) using siRNAs. The knockdown of Cullin1 but not the other five cullins remarkably elevated CDC6 protein levels. NCTD promoted the binding of Cullin1 to CDC6, thereby promoting CDC6 protein degradation through a Cullin1 neddylation‐mediated ubiquitin‐proteasome pathway. NCTD can be used in combination with radiotherapy to achieve better anticancer efficacy, or work as a radiosensitizer to overcome cancer radioresistance.
Study on impact resistance of Nano‐SiO2 reinforced STG/Kevlar composites
Authors: Lin Huan , Chen Guojing , Li Wanli , Cai Lihai , Liu Wenyan 
Published: June 2022

AbstractAs a flexible protective material, shear thickening gel (STG)/Kevlar composite still has great potential to improve its impact resistance. In this paper, a novel STG/SiO2/Kevlar flexible protective composite was prepared by impregnating STG/SiO2 into Kevlar. Due to the excellent SiO2 enhancement effect, the STG/SiO2/Kevlar exhibited a higher safeguarding property than the STG/Kevlar. The maximum yarn pull‐out force of STG/SiO2/Kevlar reached 61.7 N, which was higher than the 41.9 N of STG/Kevlar. The uniform puncture results showed that the maximum bearing capacity of STG/Kevlar and STG/SiO2/Kevlar increased by 116.8% and 215.3%, respectively, compared with pure Kevlar. The impact test results indicated that 20 layers of STG/SiO2/Kevlar could not be penetrated by the knife stab and 24 layers of STG/SiO2/Kevlar could not be penetrated by 7.62 mm pistol bullets. Finally, the enhancement mechanism of impact resistance of STG/SiO2/Kevlar composites was studied.
Reassessment of different flat TCO integrated reflectors for the crystalline silicon solar PV module in view of its longer operational life
Authors: Agrawal Monika , Chowdhury Amartya 
Published: June 2022

AbstractIn the present simulation work with experimental validation, the performance of a transparent conductive oxide (TCO) film‐coated spectrally selective reflector in the low‐concentrated photovoltaic application has been analysed. The use of mirrors in solar photovoltaic (PV) applications is a well‐established thing. However, it increases the operating temperature and requires more thermally stable, expensive solar modules. In this regard, for the first time, commercially available TCO‐coated glasses such as fluorine‐doped tin oxide (FTO) and indium tin oxide (ITO) have been integrated with mirrors. The spectrally selective reflector is a promising technology to achieve a high‐power yield from the commercially available crystalline silicon photovoltaic (C‐Si PV) module during its lifetime. They have the property to absorb unwanted photons in the region of the AM1.5 spectrum (1200 to 2000 nm), which partially thermalises the solar module through plasmonic absorption. The present study found that the proposed approach helps to restrict the increase in PV module temperature caused by the reflected rays from a mirror. The electrical performance of a standalone C‐Si PV was compared with that of the same system after the addition of FTO, ITO and a conventional mirror system. Our analysis indicates that, with the mirror integration, the degradation rate can increase to 1.5% per year if the standalone PV module's ageing rate is 0.8% per year. Through FTO incorporation with the same, the ageing rate has been reduced by up to 1.18% per year due to a reduction in temperature. This result is quite interesting, considering that spectrally selective reflectors do not stop high‐energy photons from thermalizing the PV module. The entire work has been done on commercially available materials, which makes it easier and ready to be implemented in large PV plants.Highlights

A spectrally selective mirror for PV power boosting.
Transparent conductive oxide (TCO) glass integration with mirror reduces the IR concentration approximately 50%.
The reduction in thermalisation of PV module from the mirror by 3–5°C.
This integration increases the PV module operational life by at least 4 years compared with commercial mirror.
Comparing the cost–benefit probability of management based on early‐stage and late‐stage economic thresholds with that of seed treatment of Aphis glycines
Authors: Xu Lei , Zhao Tong‐Hua , Xing Xing , Xu Guo‐Qing 
Published: June 2022

AbstractBackgroundThe current integrated pest management (IPM) curative strategy for soybean aphid, Aphis glycines Matsumura (Hemiptera: Aphididae), relies on responsive spraying foliar insecticides during the R1–R5 soybean stage when aphid abundance reaches the economic threshold (ET) of 250 aphids plant−1 (traditional IPM). By analyzing the relationship between aphid abundance and yield loss before the R1 stage, we developed an early‐stage ET. We propose to spray foliar insecticides on plants colonized with aphids using the early‐stage ET as a trigger (improved IPM), together with seed treatment to manage A. glycines and delay them exceeding the ET of 250 aphids plant−1 in the late stage for whole‐field spraying (traditional IPM). Finally, we compared the cost–benefit probabilities of the three management approaches.ResultsThe early‐stage ET over all potential yields, market prices, and control costs was 64 aphids plant−1, providing growers 7 days of preparation time to spray foliar insecticides before the economic injury level of 187 aphids plant−1 was reached. Improved IPM achieved the highest cost–benefit probabilities followed by traditional IPM, and the seed treatment achieved the lowest. However, in fields where the pressure from white grubs was high, the probability of achieving a positive net return with seed treatment was higher than that in other locations.ConclusionImproved IPM based on early‐stage ET of 64 aphids plant−1 was the most cost‐effective of all the three approaches. Neonicotinoid seed treatment can be applied as an insurance strategy to supplement A. glycines IPM in Liaoning, China. © 2022 Society of Chemical Industry.
Community‐based mosquito surveillance: an automatic mosquito‐on‐human‐skin recognition system with a deep learning algorithm
Authors: Ong Song‐Quan , Nair Gomesh , Yusof Umi Kalsom , Ahmad Hamdan 
Published: June 2022

AbstractBACKGROUNDPublic community engagement is crucial for mosquito surveillance programs. To support community participation, one of the approaches is assisting the public in recognizing the mosquitoes that carry pathogens. Therefore, this study aims to build an automatic recognition system to identify mosquitos at the public community level. We construct a customized image dataset consisting of three mosquito species in either damaged or un‐damaged body conditions. To distinguish the mosquito in harsh conditions, we explore two state‐of‐the‐art deep learning (DL) architectures: (i) a freezing convolutional base, with partial trainable weights, and (ii) training the entire model with most of the trainable weights. We project a weighted feature map on different layers of the model to visualize the morphological region used by the model in classification and compared it with the morphological key used by the expert.RESULTIt was found that the model with architecture two and the Adam optimizer achieves at least 98% accuracy in mosquito and conditions identification and when implemented on an independent dataset, the Xception model generalizes the best result with an accuracy of 0.7775 and 0.795 precision. Moreover, most of the morphological regions used by the model are able to match those of the human expert.CONCLUSIONWe report a customized DL model for performing pest mosquito taxonomy identification, and through visualization, some regions using computers to discriminate mosquito species could be adopted later in systematic identification. © 2022 Society of Chemical Industry.
Evidence for Rosa damascena efficacy in mental disorders in preclinical animal studies and clinical trials: A systematic review
Authors: Mohamadi Neda , Pourkorrani Mohammad Hossein Sotoudeh , Langarizadeh Mohammad Amin , Ranjbartavakoli Marziye , Sharififar Fariba , Asgary Sedigheh 
Published: June 2022

AbstractThe aim of this systematic review was to identify animal preclinical studies and randomized controlled trials that looked at the effects of R. damascena in any form on different mental diseases. Up to September 2021, the online databases of PubMed, Scopus, Embase, Web of Science, and Cochrane trials, as well as SID and MagIran, were searched. This study included 10 animal studies. Except for one research, the rest of the studies confirmed the positive effects of the plant in treatment of mental disorders. A total of 38 studies met the criteria for inclusion. Individuals who have encountered various sorts of mental problems, such as anxiety, sleep disturbance, and depressive disorder, were studied. R. damascena essential oil (EO), essence, extract, and dried plant were used in aromatherapy and oral administration. A decrease in sympathetic nervous system activity, induction of neurotransmitters, induction of nerve growth factors by neurogenesis and synaptogenesis mechanisms, a decrease in prolactin and an increase in noradrenaline, estradiol, and progesterone secretion are some of the mechanisms of action. In general, R. damascena is an effective herb for the treatment of mental disorders. However, further research timing and duration of intervention are needed to extrapolate the findings.
Failure modes in cedar tree revetments: Observations on rivers and streams in eastern Kansas, USA
Authors: Shelley John , Haring Christopher , Chrisman Nathan 
Published: June 2022

AbstractA cedar tree revetment is a bioengineering technique intended to stabilize eroding stream banks using longitudinally placed cedar trees. This technique, which has been implemented on many rivers and streams across the United States, has been proposed as a less expensive, ecologically compatible bank stabilization method. The limited documentation of these types of bioengineering techniques indicates high failure rates. River engineers need to understand the potential failure modes of cedar tree revetments, so they can take appropriate countermeasures when applying this technique. This article documents four common failure modes observed during post‐project site assessments on 12 streams in eastern Kansas, USA that took place in 2019 and 2020. These modes are (1) bed degradation with structure perching, (2) failure in flexion, (3) loose cables, and (4) lack of sediment infilling. Computed factors of safety for top of bank discharge range from 0.3 to 6.0 in flexion (bending stress vs. strength) and range from 1.7 to 40.1 for anchor forces vs. anchor strength. These factors of safety suggest that failure in flexion is an important failure mechanism that should be considered and mitigated during design of cedar tree revetments. Moreover, failure rate varies directly with project age. The authors hypothesize that progressive processes such as breaking of bankside branches may cause loose cables and cyclical loading and wetting/drying may lower the bending strength of the trees over time. Avoiding degrading streams, additional anchoring, and trimming the bank‐side branches of the cedar trees are suggested as means to reduce these types of failures.
New Approach Synthesis of S, N Co‐Doped Graphenes for High‐Performance Supercapacitors
Authors: Arvas Melih Besir , Gürsu Hurmus , Gencten Metin , Sahin Yucel 
Published: June 2022

AbstractIn this study, S, N co‐doped graphene‐based electrodes were synthesized by a one‐step, environmentally friendly and low−Cost method known as Yucel's method in the solutions consisting of different concentration ratios of sulfuric and nitric acids and different cycles in the certain potential range for the first time in the literature. The prepared S, N co‐doped graphene‐based electrodes were characterized by spectroscopic, microscopic and electrochemical methods. In electrochemical characterization, cyclic voltammetry and electrochemical impedance spectroscopy were used. The supercapacitor performances were examined by cyclic charge‐discharge tests of the electrodes in the specified supporting electrolyte solution. Areal capacitance values varied from 71.48 mF.cm−2 to 893.2 mF.cm−2 at a current density of 10 mA cm−2 in the prepared electrodes.