bluuebunny/crossref_metadata_2025_split huggingface dataset:
Micro, Small, and Medium Enterprises (MSMEs) Rebranding
Authors: Sholihah Dienni Ruhjatini , Fadlillah Alnisa Min , Mira Rahmi  
Published: July 2022

Micro, Small, and Medium Enterprises (MSMEs) have great potential to drive the country's economy, especially in developing countries like Indonesia. However, many views often reveal that MSMEs have low competitiveness. So, they are not considered a sustainable business and are not managed professionally, both in finance, marketing, and human resources. Therefore, currently, MSMEs are labeled as difficult to develop.
This community service aims to change the paradigm of MSMEs through small steps to rebrand our MSME Partners. This activity is performed by providing assistance to the MSME participants that are related to 3 essential aspects: finance, marketing, and human resources. The assistance method in this program is carried out in some steps. The first step is carrying out observation since the location survey was carried out. Then, the implementation is carried out in these methods: lectures of theoretical presentations, assignments, practice trials, and finally, the designing of the rebranding model. With this program, the partners are expected to be able to improve and become MSMEs that are more competitive. They must have a positive image, so they can viewed as a professional business unit and generate significant profits.
Fostering the Learning Outcomes Achievement of Class X High School Students on the Protist Concept Using The Visuospatial Wimba Learning Model
Authors: Khastini Rida Oktorida , Rifqiawati Ika , Alawiyah Tuti 
Published: July 2022

<p><em>The study was conducted to determine the influence of the visuospatial Wimba learning model for the student learning outcome of class X on the protist concept. The method used in this research was quasi-experiment with the design of the posttest only control group design. The population of this research was all X MIPA of publi madrasah aliya in Kota Cilegon. The sample of this research was X MIPA 1 as the experiment class and X MIPA 2 as control class carried out by simple random sampling. The data collection techniques used were a multiple-choice test and a 3D media assessment. The results showed in cognitive and psychomotor aspects for the experimental class were 84 and 85.14, while in the control class was 63 and 73.04. The result of the hypothesis test analysis showed the significant value of learning outcomes on cognitive and psychomotor aspects was 0,00 and 0,03 respectively which is &lt; 0,05. Thus it can be concluded that the visuospatial Wimba learning affects student learning outcomes.</em><em></em></p><br /><p><em> </em></p>
Integration Pattern of Biology and Science Learning Based on Islamic Science
Authors: Jamaludin Didi Nur , Budhi Henry Setya , Choir Muhammad Charis Mazidatul , Yusman Muhammad 
Published: July 2022

<p>The scientific integration paradigm has contributed to education. This study aims to determine the pattern of integration of Biology and science learning based on the integration of Islamic science, through field studies. The research was conducted using semi-structured interviews about experiences in integrating biology and science learning with Islamic sciences. The pattern of integration of Biology and Science based on the integration of Islamic science includes aspects of affective and cognitive. Attitudes have a pattern of development such as belief, admiration, humility, gratitude, motivation and self-awareness. Knowledge has a pattern of connecting scientific knowledge with Islamic knowledge both sourced from the Qur'an and Hadith as well as other Islamic knowledge. Biology and science learning have values that can be developed for the formation of students' character.</p><p> </p><p> </p>
Early-Career Sports Medicine Surgeons Perform a Large Volume of Non-Sports Medicine Procedures
Authors: Inclan Paul M. , Wright Rick W. , Smith Matthew V. , Brophy Robert H. 
Published: July 2022

Background:
The purpose of this study was to utilize the American Board of Orthopaedic Surgery (ABOS) Part-II Case List database to (1) define the practice patterns of sports medicine-trained ABOS Part- II Oral Examination Candidates and (2) describe the frequency and practice patterns of individuals who are dual fellowship-trained sports medicine candidates.

Methods:
The ABOS Part-II Case List database was utilized to define all cases submitted by 3,298 applicants indicating completion of a sports medicine fellowship between January 1, 2003, and January 1, 2020. Cases were classified by subspecialty category and case type. The frequency and practice patterns of candidates pursuing additional fellowship training (i.e., “dual fellowship-trained”) were recorded. Descriptive statistical methods were used to describe the annual and overall procedure volume and candidate case mix. Trends in the relative frequency of cases performed and fellowship training patterns were determined using linear regression analysis.

Results:
On average, sports medicine-trained candidates submitted 100.6 cases for review during the 6-month case collection period: 59.0 (58.6%) sports medicine/arthroscopy cases, 29.3 (29.1%) trauma/general cases, 4.5 (4.5%) adult reconstruction cases, and 7.8 (7.8%) “other” cases per candidate. Although candidates performed fewer total (r2 = 0.84, p < 0.001) and sports medicine/arthroscopy (r2 = 0.85, p < 0.001) cases over the study period, the proportion of sports medicine/arthroscopy cases did not change over the study period (p = 0.18). Dual fellowship training was indicated by 333 individuals (10.1%). The number of dual fellowship-trained candidates pursuing additional fellowship training in pediatrics and adult reconstruction increased over the study period, and the number of dual fellowship-trained candidates pursuing additional fellowship training in trauma decreased over the study period.

Conclusions:
Early-career sports medicine candidates are likely to perform >40% of cases outside of the sports medicine subspecialty. Sports medicine trainees are increasingly likely to pursue a second fellowship in pediatrics or adult reconstruction.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Perancangan Sistem Informasi Buku Penghubung Menggunakan Model User Centered Design (UCD) Berbasis Web
Authors: Doni Wicaksono  , Yoyok Seby Dwanoko  , Wiji Setiyaningsih  
Published: July 2022

Abstrak. Keberadaan teknologi informasi dalam bidang pendidikan memudahkan akses informasi secara cepat , tepat dan dapat diakses dimana saja salah satunya yaitu sistem informasi buku penghubung. TK Saint Joseph Montessori School Malang menggunakan buku penghubung sebagai penjembatan komunikasi orang tua dengan guru. Penggunaan buku penghubung secara manual memiliki kelemahan yang belum teratasi dengan baik, orang tua siswa tidak membaca buku penghubung dikarenakan anak kelupaan menyampaikan, siswa terkadang lupa membawa buku penghubung sehingga informasi tidak bisa tertuliskan dengan rutin dan jelas, sedangkan guru membutuhkan waktu yang lama dalam menuliskan buku penghubung karena harus menulis satu persatu dan berulang. Hal tersebut tentu saja menjadikan kegiatan tidak efektif dan efisien. Pembuatan sistem informasi buku penghubung berbasis web menggunakan model pengembangan UCD (User Centered Design) bertujuan untuk membangun sistem yang menyesuaikan kebutuhan dengan pengguna sehingga memudahkan komunikasi antara guru dan orang tua dalam melihat perkembangan anak di sekolah . Dari hasil penelitian yang dilakukan pembuatan sistem buku penguhubung menggunakan model pengembangan UCD (User Centered Design) dapat menghasilkan sistem yang sesuai dengan kebutuhan pengguna , berjalan sesuai fungsi yang telah diuji dengan blackbox testing dan sistem mendapatkan hasil User Acceptance Test (UAT) dengan rata – rata 84.39% dari 3 aspek pengujian sehingga dapat disimpulkan mempermudah komunikasi antara guru dan orang tua, dengan adanya sistem informasi buku penghubung proses pencatatan menjadi lebih cepat ketimbang menggunakan manual dengan buku serta lebih menghemat kertas (paperless).
Kata Kunci: buku penghubung; user centered design; komunikasi
Seni Kethek Ogleng Pacitan dan Seni Kethek Ogleng Wonogiri: Kajian Bandingan
Authors: Hendriyanto Agoes , Mustofa Arif , Sutopo Bakti 
Published: July 2022

Tujuan utama penelitian ini adalah mendeskripsikan keberadaan seni Kethek Ogleng di Kabupaten Pacitan dan di Kabupaten Wonogiri sehingga seni tersebut dapat dipahami secara komprehensif. Permasalahan utama penelitian ini adalah persamaan dan perbedaan aspek-aspek yang terdapat dalam seni Kethek Ogleng di Kabupaten Pacitan maupun yang ada di Kabupaten Wonogiri. Aspek itu antara lain aspek sejarah, gerakan, tata busana-tata rias, dan fungsi. Penelitian ini termasuk penelitian kualitatif. Hasil penelitian sebagai berikut; pertama, terdapat keterpengaruhan seni Kethek Ogleng di Wonogiri dengan yang ada di Pacitan. Penyebabnya seni Kethek Ogleng di Pacitan muncul lebih dahulu dibanding dengan yang ada di Wonogiri. Kedua, terdapat perbedaan pembagian gerak dan juga iringan antara seni Kethek Ogleng di Kabupaten Pacitan dengan di Kabupaten Wonogiri. Ketiga, segi tata busana dan tata rias secara garis besar terdapat kesamaan antara seni Kethek Ogleng di Kabupaten Pacitan dengan yang ada di Kabupaten Wonogiri, yakni sama-sama menonjolkan tokoh tari yang merepresentasikan Kethek. Namun dari segi tersebut terdapat perbedaan antara lain terletak pada pemakaian kain poleng dan tata rias wajah. Keempat, terdapat kesamaan antardua seni tersebut terletak pada fungsi. Baik seni Kethek Ogleng di Kabupaten Pacitan maupun di Wonogiri mempunyai fungsi sebagai pertujukan, menghibur, kebanggan masyarakat, dan juga sebagai sarana untuk mendidik generasi penerus.
Outbreak of vancomycin-resistant Enterococcus faecium starting among patients admitted to a surgical unit in a Swedish county
Authors: Gideskog Maria , Welander Jenny , Hällgren Anita 
Published: July 2022

Abstract
Background
Vancomycin-resistant Enterococcus faecium (VRE) is a nosocomial pathogen that causes infection mainly in patients with critical illnesses in intensive care units, severe underlying diseases or weakened immune systems. Intensive pretreatment with antibiotics and the use of urinary catheters also constitute a risk. Due to its hardy nature, the bacterium can survive for long periods in a hospital environment. The aim of this study was to describe the investigation of a sudden increase in VRE cases admitted to the surgical unit at Vrinnevi Hospital in Norrköping, Sweden, and the control measures taken.
Methods
Faecal cultures from patients admitted to the surgical unit were obtained, and environmental cultures were collected from different locations in patient rooms and medical devices. In addition, screening samples were obtained from units with high-risk patients in Östergötland County. Isolates identified as E. faecium were subjected to antibiotic susceptibility testing. Vancomycin-resistant isolates PCR-positive for the vanA/vanB gene were further analysed with whole-genome sequencing (WGS).
Results
A total of 35 VRE isolates were found (22 from patients and 13 from the environment). The WGS identified three outbreak clusters, sequence type (ST) 203, ST 1839 and ST 80, and one unique clone (ST 612). The ST 203 clone predominated among VRE cases admitted to the surgical unit.
Conclusions
With prompt infection control measures, the VRE outbreak was over after approximately four months. To prevent further outbreaks of VRE, active screening, antibiotic stewardship, improved cleaning and hand hygiene, and restriction of multiple-bed rooms is essential.
The Stat3 inhibitor F0648-0027 is a potential therapeutic against rheumatoid arthritis
Authors: Kaneko Yosuke , Ozawa Shin-ichiro , Sato Yuiko , Kobayashi Tami , Matsumoto Tatsuaki , Miyamoto Kana , Kobayashi Shu , Harato Kengo , Hirono Shuichi , Matsumoto Morio , Nakamura Masaya , Niki Yasuo , Miyamoto Takeshi 
Published: July 2022

Abstract
Background
Rheumatoid arthritis (RA) is a disease characterized by chronic joint inflammation, pain and joint destruction, leading to alteration in activities of daily living, yet pathological mechanisms underlying the condition are not fully clarified. To date, various therapeutic agents have been developed as RA therapy including DMARDs and/or biological agents that target inflammatory cytokines or inhibit JAK. Here we asked whether inhibiting signal transducer and activator of transcription 3 (Stat3) activity would antagonize RA.
Methods
Stat3 forms dimers when activated and undergoes nuclear translocalization; thus we screened approximately 4.9 million small compounds as potential blockers of protein-protein interactions required for Stat3 dimerization using in silico screening. We then tested candidate Stat3-inhibiting activity in vitro by analyzing expression of IL-6, a Stat3 target, in compound-treated fibroblasts. We also analyzed expression of RANKL, a cytokine essential for osteoclastogenesis, in vitro. We then evaluated anti-arthritis effects of candidate compounds in vivo in collagen-induced arthritis model mice. Effects of the candidate compounds on inhibiting Stat3 phosphorylation and nuclear localization following IL-6 stimulation of fibroblasts were analyzed by an immune histocochemical analysis as well as western blotting.
Results
We identified 15 as strong candidates as potential blockers of protein-protein interactions required for Stat3 dimerization using in silico screening from approximately 4.9 million small compounds. Four of the 15 significantly inhibited IL-6 as well as RANKL expression induced by IL-6. One compound, F0648-0027, significantly inhibited arthritis development without apparent adverse effects. F0648-0027 also significantly blocked Stat3 phosphorylation and nuclear localization following IL-6 stimulation of fibroblasts.
Conclusions
These data suggest that Stat3 is a target for RA, and that F0648-0027 could serve as a therapeutic reagent against the condition.
PRDM15 interacts with DNA-PK-Ku complex to promote radioresistance in rectal cancer by facilitating DNA damage repair
Authors: Yang Yanyong , Yu Yue , liu tingting , Yu Guanyu , Wang Hang , Du Zhipeng , Chen Yuanyuan , Yang Nan , Cao Kun , Liu Chunlei , Wan Zhijie , Shen Hui , Gao Fu , Zhang Wei 
Published: July 2022

Abstract
Background
Neoadjuvant chemoradiotherapy is a standard treatment for locally advanced rectal cancer; however, resistance to chemoradiotherapy is one of the main obstacles to improving treatment outcomes. The goal of this study was to explore the role of PRDM15 involved in the radioresistance of colorectal cancer and to clarify the underlying mechanism.
Methods
The expression and localization of PRDM15 was measured with Western blot and immunofluorescence assay. Lenti-virus was applied to perform knockdown or overexpression of PRDM15. Colorectal cancer cells exposed to γ-rays were assayed by DNA damage, cytotoxicity, apoptosis and cell cycle. Moreover, DNA damage response was detected and immunoprecipitation was used to explore protein interactions. The potent role of PRDM15 in overcoming radioresistance was investigated in CDX and PDX models. Finally, the correlation between PRDM15 expression and clinical outcomes were investigated in 80 locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy.
Results
After DNA damage, PRDM15 was upregulated and localized to DNA damage sites, colocalized with γH2AX. Knockdown of PRDM15 inhibited DNA damage repair and increased radiosensitivity in colorectal cancer cells. Mechanistically, PRDM15 promoted DNA repair by interacting with DNA-PKcs and Ku70/Ku80 complex. Knockdown of PRDM15 sensitized CDX and PDX models to radiotherapy. Higher PRDM15 expression in cancer tissue was associated with inferior tumor regression and poorer prognosis in colorectal cancer patients treated with neoadjuvant chemoradiotherapy.
Conclusions
Our findings revealed that inhibiting PRDM15 was potent to overcome radioresistance through abrogating DNA repair in colorectal cancer cells. Additionally, the expression level of PRDM15 could be applied to predict radiotherapy responsiveness in rectal cancer patients.
Revisiting QUIC attacks: A comprehensive review on QUIC security and a hands-on study
Authors: Chatzoglou Efstratios , Kouliaridis Vasileios , Karopoulos Georgios , Kambourakis Georgios 
Published: July 2022

Abstract
Built on top of UDP, the recently standardized QUIC protocol primarily aims to gradually replace the TCP plus TLS plus HTTP/2 model. For instance, HTTP/3 is designed to exploit QUIC’s features, including reduced connection establishment time, multiplexing without head of line blocking, always-encrypted end-to-end security, and others. This work serves two key objectives. Initially, it offers the first to our knowledge full-fledged review on QUIC security as seen through the lens of the relevant literature so far. Second and more importantly, through extensive fuzz testing, we conduct a hands-on security evaluation against the six most popular QUIC-enabled production-grade servers. This assessment identified several effective and practical zero-day vulnerabilities, which, if exploited, can quickly overwhelm the server resources. This finding is a clear indication that the fragmented production-level implementations of this contemporary protocol are not yet mature enough. Overall, the work at hand provides the first wholemeal appraisal of QUIC security from both a literature review and empirical standpoint, and it is therefore foreseen to serve as a reference for future research in this timely area.
Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer evolution
Authors: Tsujioka Masatsune , Miyazawa Keisuke , Ohmuraya Masaki , Nibe Yoichi , Shirokawa Tetsuya , Hayasaka Haruko , Mizushima Tsunekazu , Fukuma Takeshi , Shimizu Shigeomi 
Published: July 2022

Abstract
Numerous studies have investigated the various cellular responses against genotoxic stress, including those mediated by focal adhesions. Nevertheless, we here identified a novel type of focal adhesion remodelling that occurs under genotoxic stress conditions, which involves the replacement of active focal adhesion kinase (FAK) with FAK-related non-kinase (FRNK). FRNK stabilized focal adhesions, leading to strong cell-matrices adhesion, and FRNK-depleted cells were easily detached from the matrices upon genotoxic stress. This remodelling occurred in a wide variety of cells. In vivo, the stomachs of Frnk-knockout mice were severely damaged by genotoxic stress, highlighting the protective role of FRNK against genotoxic stress. FRNK was also found to play a vital role in cancer progression, because FRNK depletion significantly inhibited cancer dissemination and progression in a mouse cancer model. We hence conclude that this novel type of focal adhesion remodelling reinforces cell adhesion and acts against genotoxic stress, which results in the protection of normal tissues, but, in turn, facilitates cancer evolution.
WITHDRAWN: Industry 4.0 and Renewable Energy Nexus
Authors: Bildirici Melike , Kayıkçı Fazıl 
Published: July 2022

Abstract
In line with the fourth industrial revolution programs, most of the countries have imposed variety of regulations or policies for the goals of energy conservation, sustainable development, and industrial transition. This paper tested the relation among macroeconomic variables such as economic growth, renewable electricity generations (% of GDP), Industry 4.0 investment, which is proxied by ICT goods and service exports (% GDP) and research and development expenditure for G20 countries in 2000–2019 period by employing Panel Quantile Regression approach. According to results, these variables relate to each other. Elasticities are greater than 1 in most cases except growth elasticity of renewable energy production is greater than 1. Results indicate that economic growth improves both Industry 4.0 process and renewable energy output while Industry 4.0 process improves renewable energy output. These results suggests for policymakers to accelerate economic growth policies and promote Industry 4.0 advancements to have more renewable energy output.Jel Codes: O14, O32, O44, Q20, Q42
In vitro comparison of the Viability and Proliferation of Human Gingival Fibroblasts and Osteoblast-like MG-63 Cells on Three Different Temporary Cements Used in Dental Implants
Authors: Yaghobee Siamak , Aslroosta Hoori , Hasannia Sadegh , Poursafar Farzaneh 
Published: July 2022

Abstract
Background: Regarding retained cement acts as an idiopathic cause for early implant loss, cement selection with the least toxicity in the peri-implant hard and soft tissues is important. The present study aimed to evaluate the cytotoxicity of three different types of temporary cements and titanium cemented with each cement after direct exposure to human gingival fibroblasts (HGF) and MG-63 osteoblast-like cells.Methods: In this in vitro study, zinc oxide-eugenol (ZOE), eugenol-free zinc oxide (ZONE), and resin (R) cements prepared in cylindrical forms with a similar dimension were used. Each cement was placed on titanium disks to prepare cemented titanium samples. MTT assay was applied at 24- and 72-hour, and 7-day intervals to evaluate cytotoxicity.Results: All the cements decreased cell viability in both cell lines significantly. None of the cements exhibited cellular viability percentages higher than the minimum percentage (70%) required for biocompatibility. The cemented titanium disks’ cytotoxicity was not significantly different from the cement-only samples (P>0.05). There were no significant differences in the sensitivity of MG-63 osteoblast-like cells and HGF to the cements evaluated. Conclusions: The composition of the cement had a significant role in the host cell response. This study showed that dental cements could cause tissue toxicity in the gingiva and bones, finally affecting implant survival.