bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complications and Efficacy of Sinopharm Vaccine among Liver and Kidney
Transplantation
Authors: Khodashahi Rozita , Aliakbarian Mohsen , Sabbagh Mahin Ghorban , Rezayat Kambiz Akhavan , Khodashahi Mandana , Khaleghi Ebrahim , Moghaddam Maliheh Dadgar , Razmkhah Baran , Nazar Mahdi Nik , Sheikhi Nadia 
Published: March 2022

Background:
There are various vaccines against the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). However, vaccination may lead to some complications.

Objective:
This study aimed to investigate the complications of transplant recipients who received
the Sinopharm COVID-19 vaccine.

Methods:
This was a retrospective cross-sectional study conducted among 667 transplant recipients
(211 liver transplant recipients and 456 kidney transplant recipients) who received the Sinopharm
COVID-19 vaccine from March to August 2021 and had medical records in Montaserieh Hospital,
affiliated to Mashhad University of Medical Sciences, Mashhad, Iran. The demographic and clinical
information, as well as patient's symptoms after each dose of the vaccine, were recorded.

Results:
Only 16.8% and 13.7% of the patients experienced some symptoms following the first and
second doses of the Sinopharm vaccine, respectively. No significant difference was observed between
patients younger than 50 years and those aged 50 years and over in terms of the complication
rate of the Sinopharm vaccine (P>0.005). Vaccine failure was reported in 10% of the cases;
however, the mortality rate due to infection with the Delta variant of COVID-19 in this population
was reported to be 0.7%.

Conclusion:
Based on the obtained results, adverse reactions of the Sinopharm COVID-19 vaccine
are generally mild, predictable, and non-life-threatening both in the first and second doses. Vaccine
failure was reported in 10% of the cases; however, mortality due to infection with the Delta variant
of COVID-19 was reported in less than 1% of the cases.
Modulation of Bleomycin-induced Oxidative Stress and Pulmonary Fibrosis
by Ginkgetin in Mice via AMPK
Authors: Wang Lei , Zhang Chaofeng , Ren Guoqing , Xu Gonghao , Li Renshi , Xie Haifeng , Cui Zhengguo 
Published: March 2022

Background:
Ginkgetin, a flavonoid extracted from Ginkgo biloba, has been shown to exhibit broad anti-inflammatory, anticancer, and antioxidative bioactivity. Moreover, the extract of Ginkgo folium has been reported on attenuating bleomycin-induced pulmonary fibrosis, but the anti-fibrotic effects of ginkgetin are still unclear. This study was intended to investigate the pro-tective effects of ginkgetin against experimental pulmonary fibrosis and its underlying mechanism.

Methods:
In vivo, bleomycin (5 mg/kg) in 50 μL saline was administrated intratracheally in mice. One week after bleomycin administration, ginkgetin (25 or 50 mg/kg) or nintedanib (40 mg/kg) was administrated intragastrically daily for 14 consecutive days. In vitro, the AMPK-siRNA trans-fection in primary lung fibroblasts further verified the regulatory effect of ginkgetin on AMPK.

Results:
Administration of bleomycin caused characteristic histopathology structural changes with elevated lipid peroxidation, pulmonary fibrosis indexes, and inflammatory mediators. The bleo-mycin-induced alteration was normalized by ginkgetin intervention. Moreover, this protective ef-fect of ginkgetin (20 mg/kg) was equivalent to that of nintedanib (40 mg/kg). AMPK-siRNA trans-fection in primary lung fibroblasts markedly blocked TGF-1-induced myofibroblasts transdiffer-entiation and abolished oxidative stress.

Conclusions:
All these results suggested that ginkgetin exerted ameliorative effects on bleomycin-induced oxidative stress and lung fibrosis mainly through an AMPK-dependent manner.
Antifungal Activity of Plant Secondary Metabolites on Candida albicans: An Updated Review
Authors: Khan Andleeb , Moni Sivakumar Sivagurunathan , Ali M. , Mohan Syam , Jan Huma , Rasool Saiema , Kamal Mohammad A , Alshahrani Saeed , Halawi Maryam , Alhazmi Hassan A 
Published: March 2022

Abstract:Fungal infections have been increasing continuously worldwide, especially in immunocompromised individuals. Fungi, regarded as eukaryotic pathogens, have many similarities to the host cells, which inhibit anti-fungal drug development progress. Various fungal model systems have been studied, and it was concluded that Candida spp. is the most common disease-causing fungus. Candida species are well known to cause infections not only in our mouth, skin, and vagina, but they are also a frequent cause of life-threatening hospital bloodstream infections. The morphological and developmental pathways of Candida have been studied extensively, providing insight into the fungus development. Candida albicans is known to be the most pathogenic species responsible for a variety of infections in humans. Conventional anti-fungal drugs, mainly azoles drugs available in the market, have been used for years developing resistance in C. albicans. Hence, the production of new anti-fungal drugs, which require detailed molecular knowledge of fungal pathogenesis, needs to be encouraged. Therefore, this review targets the new approach of "Green Medicines" or the phytochemicals and their secondary metabolites as a source of novel anti-fungal agents to overcome the drug resistance of C. albicans, their mechanism of action, and their combined effects with the available anti-fungal drugs.
Study on Decoupling Control Strategy of Redundant Parallel Hybrid
Vibration Isolation Platform
Authors: Zhang Bing , Yan Liu , Qiu Longtao , Huang Hua , Cai Jiamin , Yang Xinlong , Tang Shaodong 
Published: March 2022

Background:
The vibration isolation platform (VIP) can greatly reduce the risk of damage to
dynamic equipment caused by external vibration interference and provide the most stable and reliable
working environment for dynamic equipment.

Objective:
Aiming at the problems of small vibration isolation dimension, low bearing capacity, serious
motion coupling, and narrow vibration isolation bandwidth in the field of vibration isolation of dynamic
load equipment, a hydraulic redundant six degrees of freedom parallel vibration isolation platform
(PVIP) with active and passive composite vibration isolation support is proposed.

Methods:
The dynamic coupling model of active and passive hybrid vibration isolation (APHVI) of redundant
PVIP is established, and the matrix diagonal decoupling control strategy and fuzzy PI control
theory are combined. Analysis of passive vibration isolation performance and APHVI performance of
VIP is done.

Results:
The simulation results show that the effect of APHVI based on fuzzy PI decoupling control is
better than that of passive vibration isolation and matrix diagonal decoupling control.

Conclusion:
Fuzzy PI control can effectively attenuate more than 98 % of the disturbance, significantly
improve the vibration isolation performance and decoupling effect of the platform, and expand the effective
vibration isolation bandwidth.
Laypeople’s Online Health Information Search Strategies and Use for Health-Related Problems: Cross-sectional Survey
Authors: Chiu Yen-Lin , Tsai Chin-Chung , Liang Jyh-Chong 
Published: March 2022

Background
With the increase in the use of the internet to search for health information about health-related problems, there is a need for health care professionals to better understand how their patients search for and use the online health information that may influence their medical decision making.

Objective
The aims of this study are to explore laypeople’s online health information search strategies and examine the relationships between their search strategies and utilization behavior of online health information.

Methods
Two scales, namely match and elaboration, were used to measure patients’ basic search strategies (ie, simple approach) and advanced search strategies (ie, integrative approach), respectively. In addition, the consultation scale was used to evaluate the participants’ use of online health information to consult doctors and others. A total of 253 outpatients without university education were purposely selected and surveyed. The participants were outpatients at a university-affiliated teaching hospital. Partial least squares-structural equation modeling (PLS-SEM) was performed to analyze the measurement model to specify the measurement validation. In addition, the structure model of PLS-SEM was evaluated to examine the path correlations between variables and to execute interaction effect and curvilinear relationship analyses.

Results
The results of the path correlation analysis by PLS-SEM showed that both elaboration strategy (path coefficient=0.55, P<.001) and match strategy (path coefficient=0.36, P<.001) were positively correlated with consultation on online health information with doctors and others. In addition, interaction effect and curvilinear relationship analyses indicated that there was a significant interaction effect between elaboration and match on consultation (path coefficient=–0.34, P<.001) and a significant curvilinear relationship between match and consultation (path coefficient=–0.09, P=.046).

Conclusions
Increasing patients’ exposure to online health information through both a simple search approach (ie, match strategy) and a complex search approach (ie, elaboration strategy) may lead them to appropriately use the information to consult doctors and others. However, the results of interaction effect and curvilinear relationship analyses highlighted the essential role of the elaboration strategy to properly locate, evaluate, and apply online health information. The findings of this study may help health care professionals better understand how to communicate with their patients through the health information on the internet.
ANALISIS KOMPARATIF KINERJA KEUANGAN BERBASIS TINGKAT STRUKTUR MODAL PADA PERUSAHAAN PERTAMBANGAN SUB SEKTOR BATU BARA YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Sari Eka Purnama 
Published: March 2022

<p><em>Tujuan dari penelitian ini adalah agar dapat mengetahui perbandingan antara kinerja keuangan perusahaan yang dilihat dari struktur modal di Perusahaan Pertambangan Sub Sektor Batu Bara yang terdaftar di Bursa Efek Indonesia periode 2017-2019. Sampel yang digunakan dalam penelitian ini adalah metode purposive sampling dengan beberapa kriteria. Populasi sebanyak 25 perusahaan dan sampel yang digunakan hanya sebanyak 20 perusahaan sesuai dengan kriteria yang telah ditentukan. Dalam penelitian ini analsis yang digunakan adalah metode uji independent t test. Hasil dari uji ini menunjukkan bahwa perusahaan yang memiliki high leverage dan liw leverage yang menggunakan tolak ukur Return On Equity 9ROE), Total Asset Turnover (TATO) tidak adanya perbadaan yang signifikan. Namun untuk tolak ukur Current Ratio menunjukkan hasil berbeda untuk perusahaan yang high leverage dan low leverage. Maka dari itu perusahaan dianjurkan untuk meningkatkan kembali kinerja keuangan untuk memperoleh hasil yang lebih baik dan optimal. </em></p>
Comparison of safety and efficacy of combinations of Azilsartan-medoxomil/Chlorthalidone and Olmesartan-medoxomil /Hydrochlorothiazide among hypertensive patients: A meta-analysis and systematic review
Authors: Khatri Mahima Khatri Mahima , Kumar Satesh , Siddiqui Asad Ali , Llerena Jordan , Anumolu Akhil Raj , Panakala Sowkhya , Memon Rahat Ahmed , Nadeem Taha , Tanveer Fatima 
Published: March 2022

Aims: This study intends to compare AZI-M/CT’s efficacy and
side effect profile to the OLM/HCTZ in hypertensive patients.
Materials and methods: Online databases (PubMed, Google
Scholar, and ClinicalTrials.gov) were searched until January 15, 2022,
for original articles exploring the effects of AZI-M/CT on pertinent
outcomes among hypertensive patients in contrast to OLM/HCTZ. Data on
baseline characteristics and endpoints were extracted. Review Manager
version 5.4.1 and STATA 16.0 were used for analyses. Risk ratios (RR)
and the weighted mean differences (WMD) with corresponding 95%
confidence intervals were calculated.
Results: Four studies were included having 3146 patients in
total (AZI-M/CT: 1931 and OLM/HCTZ: 1215). The pooled analysis exhibited
that compared to OLM-HCTZ, mean DBP was significantly lower in the
AZI-M/CT group (WMD –2.64 [-2.78, -2.51]; p= <0.00001,
I2= 1%), whereas no significant differences were noted in mean SBP (WMD
–2.95 [-6.64,0.73]; p= 0.12, I2=100%) and achievement of target
blood pressure (RR 0.95 [0.84,1.07]; p= 0.36, I2= 80%).
Additionally, the risk of any TEAE (RR 1.11 [1.03, 1.20]; p= 0.007,
I2= 51%) and serious adverse events RR 1.58 [1.20, 2.08]; p= 0.001,
I2= 11%) was significantly higher in the AZI-M/CT group. However, no
significant differences were observed in the risk of mortality between
the two groups (RR 0.74 [0.14, 3.91; p = 0.72, I2= 0%).
Conclusions: Our pooled analysis indicates that AZI-M/CT is
more efficient at lowering blood pressure in elderly hypertensive
patients than OLM/HCTZ. However, given the limited number of studies,
positive results should be discretely re-evaluated and require further
research.
Keywords: Azilsartan-medoxomil; Meta-analysis; Chlorthalidone;
AZI-M/CT; Olmesartan-medoxomil; Systematic review; OLM/HCTZ.
Stochastic inverse modeling of gravity data of the Prospecto Jaguaquara, Bahia, Brazil
Authors: Amarante Eduardo Menezes de Souza , Sampaio Edson Emanoel Starteri 
Published: March 2022

ABSTRACT. The ground gravity survey of the Jaguaquara Prospect followed up the airborne magnetic survey aiming to correlate the gravity and magnetic anomalies. The determination of the density contrasts of the rocks is important to distinguish between mineralized and barren zones. Our goal was to determine the densities that allowed recovering the main observed gravimetric field features based on stochastic inversion. The regional gravity field has been simulated by a two-dimensional linear function and subtracted from the Bouguer data to compute the residual gravity field. A singular value decomposition low-pass filter was applied to delete high frequency noise. This residual has been submitted to a linear inverse modeling with the Particle Swarm Optimization algorithm with 300 bodies in two steps: by optimizing the search window of the parameters using the estimator of the confidence interval in a population with 30 solutions; by computing the mean and the median of each parameter for another population of the same size and constructing two density models from these measurements of the central tendency. The results showed that there is a zone with a possible enrichment of ferrous elements and probably due to hydrothermal alteration in the depth range of 50 m to 250 m.Keywords: gravimetric anomalies, stochastic inverse modeling, Prospect Jaguaquara. Inversão estocástica de dados gravimétricos do Prospecto Jaguaquara, Bahia, BrasilRESUMO. O acompanhamento gravimétrico da anomalia magnética de dados aerotransportados do Prospecto Jaguaquara teve como objetivo correlacionar as anomalias gravimétricas e magnéticas. A determinação dos contrastes de densidade das rochas é importante a fim de distinguir as zonas possivelmente mineralizadas das estéreis. O objetivo desse trabalho foi determinar as densidades que recuperassem as principais feições gravimétricas do campo observado a partir da inversão estocástica. O campo regional foi simulado através de uma função linear bidimensional que ao subtraí-lo do mapa Bouguer, o campo residual foi calculado. Aplicamos o filtro passa-baixa de decomposição em valor singular para retirar os ruídos de alta frequência. Este resíduo foi submetido a uma modelagem linear inversa com o algoritmo Enxame de Partículas com 300 corpos em duas etapas. Inicialmente, construímos uma janela de busca otimizada para cada parâmetro usando o intervalo de confiança para uma população com 30 soluções. Por fim, calculamos a média e mediana de cada parâmetro para outra população do mesmo tamanho e foram construídos dois modelos de densidades a partir dessas medidas de tendência central. O resultado mostrou que na faixa de profundidade entre 50 a 250 m existe uma zona com possível enriquecimento de elementos ferrosos, provavelmente devido à alteração hidrotermal.Palavras-chave: anomalias gravimétricas, modelagem inversa estocástica, Prospecto Jaguaquara.
Corrected acoustic Poynting vector and its application in reverse-time migration
Authors: Eugenio Lucas Ferreira Conz , Di Bartolo Leandro 
Published: March 2022

ABSTRACT. Reverse-time migration (RTM) is the most important seismic imaging method for complex subsurface geology. However, the simple use of the traditionally applied cross-correlation imaging condition leads to a strong low-frequency noise in the final images. Many studies have proposed solutions to this problem, either by applying filters in the image domain, such as the Laplacian filter, or by developing new imaging conditions. One example is the imaging condition that correlates only the wavefield components with opposite propagation directions in forward and backward extrapolation. In this paper, it was applied the latter technique using the acoustic Poynting vector to determine the propagation directions. The wavefield extrapolation uses a staggered-grid finite difference scheme. To guarantee that the displacement velocities are considered at the correct grid position, it was applied a linear interpolation in the Poynting vector. This procedure can improve the wavefield decomposition and the final migration results.Keywords: Marmousi model, denoising, noise suppression, acoustic wavefield Vetor de Poynting acústico corrigido e sua aplicação na migração reversa no tempoRESUMO. A migração reversa no tempo é o método de imageamento sísmico mais importante para geologias de subsuperfície complexas. No entanto, o uso da tradicionalmente aplicada condição de imagem de correlação cruzada introduz fortes ruídos de baixa frequência nas imagens finais. Muitos estudos propuseram soluções para este problema, seja aplicando filtros no domínio da imagem, como o filtro Laplaciano, ou desenvolvendo novas condições de imagem. Um exemplo é a condição de imagem que correlaciona somente as componentes do campo de ondas cujas direções de propagação sejam opostas na extrapolação direta e reversa. Nesse artigo, foi aplicada esta última técnica utilizando o vetor de Poynting para determinar as direções de propagação. A extrapolação de campos de ondas utiliza um esquema de diferenças finitas de malhas intercaladas. Para garantir que os campos de deslocamento de velocidades sejam considerados na correta posição da malha, uma interpolação linear foi aplicada no vetor de Poynting. Esse procedimento pode melhorar a decomposição do campo de ondas e os resultados finais de migração.Palavras-chave: Modelo Marmousi, supressão de ruído, campo de ondas acústico
Some Aspects of the Development of the Prony Filtering Method
Authors: Oliveira Igor Barbosa , Mitrofanov Georgy M. , Priimenko Viatcheslav I. , Freires Carlos P. S. 
Published: March 2022

ABSTRACT. Decomposition based on the Prony transform is widely used to solve various engineering and scientific problems, representing a discrete dataset in the form of a linear combination of complex exponentials or damped sinusoids. Each of these functions is determined by four real parameters: amplitude, attenuation, frequency and phase. In this article, we propose a new workflow, based on the classical Prony and Matrix Pencil methods to determine the damped signals considering their locality and frequency heterogeneity. After estimating the parameters a certain procedure is constructed. This procedure selects the parameters using different criteria and can be called as Prony filtering. We have demonstrated the capabilities of the proposed algorithms and workflow, which provide an optimal set of damped terms for the Prony decomposition for an arbitrary window. The results obtained show good accuracy in the selection of the decomposition components and posterior approximation of damped signals. The accuracy of the results is guaranteed by the quasi-orthogonality of the basis functions of the Prony decomposition on finite intervals.Keywords: Prony’s method; Matrix Pencil method; damped signals; signal fitting Alguns Aspectos do Desenvolvimento do Método de Filtragem de PronyRESUMO. A decomposição baseada na transformada de Prony é amplamente utilizada na solução de vários problemas de engenharia e científicos, representando um conjunto de dados discretos na forma de uma combinação linear de exponenciais complexas ou sinusóides amortecidas. Cada uma dessas funções é determinada por quatro parâmetros reais: amplitude, atenuação, frequência e fase. Neste artigo, propomos um novo fluxo de trabalho, baseado nos métodos clássicos de Prony e Matrix Pencil, para determinar os sinais amortecidos considerando sua localização e heterogeneidade de frequência. Após estimar os parâmetros, um determinado procedimento é construído. Este procedimento seleciona os parâmetros usando critérios diferentes e pode ser chamado filtragem de Prony. Demonstramos as capacidades dos algoritmos e do fluxo de trabalho propostos, que fornecem um conjunto ótimo de termos amortecidos para a decomposição de Prony em uma janela arbitrária. Os resultados obtidos mostram boa precisão na seleção dos componentes da decomposição e posterior aproximação dos sinais atenuados. A acurácia dos resultados é garantida pela quase-ortogonalidade das funções de base da decomposição de Prony em intervalos finitos.Palavras-chave: Método de Prony; Método Matrix Pencil; sinais amortecidos; ajuste de sinal How to cite:
Calidad de vida relacionada con la salud, Expectativas y Satisfacción Académica de jóvenes universitarios
Authors: García-García Jesus Alberto , Carrizales-Berlanga Daniella 
Published: March 2022

Introducción: El objetivo del trabajo fue determinar la relación entre las dimensiones de la calidad de vida relacionada con la salud y las expectativas académicas de resultado, las expectativas de futuro, metas de progreso y la satisfacción escolar de jóvenes universitarios. Método: La investigación fue observacional, descriptiva, correlacional y con diseño transeccional. En este estudio participaron 346 jóvenes universitarios (51 %= hombres y 49 % mujeres), de 18 a 23 años, la forma de selección de la muestra fue por conveniencia. Se utilizó el cuestionario SF-12 que evalúa la calidad de vida relacionada con la salud en ocho dimensiones; función física, rol físico, dolor corporal, salud general, vitalidad, función social, rol emocional y salud mental, y las escalas de; expectativas académicas de resultado, metas de progreso académicas, satisfacción escolar y expectativas de futuro. Resultados: Los resultados indican la existencia de altos puntajes en dimensiones como la función física, rol físico y rol emocional, excepto en la función social. Se observó correlación entre las dimensiones que integran el componente de salud física con las expectativas académicas, satisfacción académica y expectativas de futuro. A su vez, el componente de salud mental se correlacionó con las metas de progreso académicas, expectativas académicas de resultado, satisfacción académica y expectativas de futuro. Conclusiones: los jóvenes universitarios tienen una buena calidad de vida, sin embargo, existe una proporción de estudiantes que no adoptan hábitos saludables y otros sí. La salud física y mental son aspectos importantes en los estudiantes, no obstante, los universitarios no visualizan el impacto de dichos beneficios en el éxito escolar, el logro de sus expectativas académicas, metas de progreso e incluso en sus expectativas de futuro.