bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Chronic Kidney Disease on Handgrip Strength: A Cross-Sectional Study in Ha’il, Saudi Arabia
Authors: Ibrahim Ahmed Abdelmoniem , Hakami Hamad Ali , Abdelbasset Walid Kamal 
Published: March 2022

Background: in chronic kidney disease (CKD) patients, there is a loss of muscle mass due to chronic inflammation, nutritional deficiencies, and metabolic acidosis, these factors lead to decreased physical fitnessand poor clinical outcomes. Handgrip strength (HGS) is an index for physical function, the aim of our study was to investigate the relationship between CKD and handgrip strength (HGS) in Ha'il, Saudi Arabia.
Methods: We conducted a cross-sectional study consisting of 251 CKD patients in Ha'il, Saudi Arabia.132 males and 119 females, aged between 25 and 65 years. Renal function (creatinine, and blood urea nitrogen) and Hand grip strength (HGS) were recorded for all patients.
Results: 3.2 kg/BMI for males and 1.8 kg/BMI for women were the average relative HGS (kg/BMI). In both sexes, HGS was inversely correlated with age and height and positively correlated with body weight and BMI, whereas the opposite was true for relative HGS.
Conclusions: Relative HGS is an effective way to quantify muscle strength in chronic renal disease patients based on their body mass. As a result, relative HGS may be a valuable and cost-effective method for the detection of kidney disorders that are chronic in nature.
Frequency of Celiac Disease in Type 1 Diabetic Children Presenting at Tertiary Care People Medical College Hospital Nawabshah Pakistan
Authors: Jamali Ameer Ali , Langah Azizullah , Memon Naseer Ahmed , Almani Badarudin , Jamali Safdar Ali , Ayaz Attiya , Devi Durga , Ahmer Arslan 
Published: March 2022

Objective: The goal of this research has been to find out how common celiac disease is in type 1 children with type 1 diabetes who visit multispecialty hospitals.
Methodology: This was a cross-sectional research. This study was directed at Pediatric Medicine Department, Mother and Child Healthcare (M&CH) ⁄ People Medical College (PMC) Hospital Nawabshah Shaheed Benazeerabad. The length of research was from 07/09/2020 to 06/03/2021, (6 months) next to the authorization of synopsis. Current research included 124 children of together sex aged between 1 to 12 years diagnosed of Type-I diabetes mellitus who were assessed for concomitant presence of celiac disease which was labeled on duodenal biopsy revealing crypt hyperplasia and villous atrophy. Frequency of celiac disease was noted and compared across various subgroups of diabetic children based on age, gender, duration of diabetes, BMI and glycemic control. Each kid's parents signed written consent form.
Results: The average ages of the children were 8.6±2.6 years. The majority of the children (n=68, 54.8 %) were aged 10 and over, preceded by kids aged 6-9 years (36.3 %), and children aged less than 5 years (08.9%). There were 56 (45.2%) boys and 68 (54.8%) girls with boys to girls ratio of 1.1.2. The average lengths of diabetes were 03.2±1.4 year. 51 (41.1%) children had poor glycemic control (HbA1c ≥8.0%). Celiac disease were established in 14 (11.3%) youngsters having Type-I diabetes. Statistically no substantial variance in the frequency of celiac disease across various subgroups of Type-I diabetic children based on age (p =0.966), sex (p =0.854), length of diabetes (p-value=0.985), BMI (p =0.835) & status of glycemic control (p =0.889).
Conclusion: A significant number of children with Type I diabetes had celiac disease in the current study, indicating that regular screening of diabetic children is necessary for prompt detection and management of celiac disease in upcoming clinical settings.
Wearable Devices and mHealth: The Significant Applications in COVID 19 Pandemic
Authors: Choudhari Ganesh , Wagh Prajakta , Choudhari Vishnu , Gawade Ashwini , Gadhave Ranjit , Bobade Chandrashekhar 
Published: March 2022

Wearable devices (WDs) and mHealth (Mobile Health) give you the healthcare services, overcoming geographical, temporal or even organizational obstacles. Wearable technologies will have non-encroaching and sovereign devices that collect save and examine physiological information that will certainly help to improve patient health. It has been used so far for fitness purposes. But with increasing demand by patients and health care workers, wearable devices have also been developed to monitor patient health-related issues. It collects and analyses data. In some scenarios makes a sensible decision and provide a suitable response to the users. Now a day, mobile applications have also proven effective in the field of medicine with the motto of giving personalized treatment to disease control. Advanced technology in wearable gadgets has become a great aspect of our day-to day life in addition to the health care industry.
A global pandemic that the world is facing in the form of COVID19 has come up with the importance of clinical research and technologies which help to tackle COVID 19 infection worldwide in an exceptional manner. While expected results have been found on effective use of wearable devices and mHealth systems to study the structure of COVID 19 and upcoming infectious ailment. The objective of this review is to test permitting technologies and structures with diverse utility to deal with the COVID 19 disaster. This review acknowledges the researchers of the wearable devices and mHealth systems which proved their significance in the present pandemic. Also, this review explains the exceptional tracking devices, which include heart rate, temperature and oxygen monitoring that, are used to diagnose COVID 19 patients.
Basal Cell Carcinoma: In Tertiary Care Center, Demographic Details and Histological Subtypes at Pumhs-W Nawabshah, Pakistan
Authors: Bano Shazia , Parveen Kousar , Ahmed Hafiz Bashir , Chandio Sardar Khatoon , Sabeen Hina 
Published: March 2022

Background: Skin malignancies are more common in fair-skinned persons, but their increasing incidence is alarming in our population.
Objective: To evaluate the Basal Cell Carcinoma (BCC) in a tertiary care center, in terms of frequency, age, sex, sites, and histological subtypes.
Methods: A retrospective work was conducted in the Dermatology and Pathology departments, Peoples University of Medical & Health Sciences, Nawabshah, from November 2020 to November 2021, total 100 cases collected by nonprobability consecutive technique, all the patients included reported at the outpatient department during one year period. All the clinical demographic data was collected in the Dermatology department and the biopsy sample was processed in the Pathology department. The observations were recorded on a structured proforma, statistically analyzed on SPSS 20 and the results were tabulated.
Results: A total of 100 cases were assessed, the age of patients ranged from 22-86 years with a female preponderance. Most of the cases were detected in the 61-80 years age group. Cheek was the most common site. The nodular/solid variety was diagnosed in most cases (54%).
Conclusion: In all the histological subtypes about both genders the density of BCC was relatively higher over the face, followed by the trunk. The nodular/solid variety is more common.
Path planning of robotic arm based on deep reinforcement learning algorithm
Authors: Al‐Gabalawy Mostafa 
Published: March 2022

AbstractRobotic Arms are used in many fields due to their high accuracy. A robotic arm has the advantage of solving the same tasks as a human arm because of its similar structure and working repetitively and independently of any human. Setting up a robotic arm's task requires the engineer to plan a path for solving the task. Using an approach with reinforcement learning to make the robotic arm learn the path independently has not been feasible due to robotic arm tasks' sparse rewards. A recently successful method of using Reinforcement Learning is the concept of Hindsight Experience Replay. This article extends the difficulty of existing tasks to two new tasks and examines Hindsight Experience Replay's performance on these tasks. In the first experiment, the robotic arm has to move a ball towards a point that is far outside of its reach, similar to golf. In the second experiment, the task is to toss a ball into a box outside its reach, similar to basketball. Results show that vanilla Hindsight Experience Replay performs poorly on these tasks. Further research on solving the tasks with improvements to Hindsight Experience Replay, like Hindsight Goal Generation and Energy‐Based Hindsight Experience Prioritization, is required to solve them further.
Toward Optimal False Data Injection Attack against Self‐Triggered Model Predictive Controllers
Authors: He Ning , Ma Kai , Li Ruoxia 
Published: March 2022

AbstractThis paper is aimed at exploring the optimal false data injection (FDI) attack against continuous time self‐triggered model predictive control (STMPC) systems with sample‐and‐hold input signals to address the potential security defects. First, the mathematical model of FDI attack against the considered STMPC system is established. Then, the difference between the states of the nominal system and the attacked system is explicitly calculated such that the impact of FDI attacks on the STMPC systems can be quantitatively analyzed. And finally, an efficient and effective algorithm to realize the desired FDI attack is proposed, and in order to maintain the flexibility of the attacker, the designed FDI attack algorithm is developed under different attacking scenarios, including attacking a single control node at each sampling time and attacking multiple control nodes each time. Finally, two simulation experiments are carried out based on a robot system and a cart–damper–spring system to verify the efficacy and optimality of the designed FDI attack strategy.
Structural Modifications and Enhanced Thermoelectric Performance of CuI Nanoparticles Induced via Al‐Doping
Authors: Salah Numan , Alshahrie Ahmed , Aljaghtham Mutabe , Saeed Abdu , Baghdadi Neazar , Koumoto Kunihito 
Published: March 2022

AbstractThermoelectric (TE) materials are of great importance for harvesting thermal energy from waste or solar heat. One of the promising TE materials is copper iodide (CuI), which is nontoxic, earth‐abundant, and has a high Seebeck coefficient at room temperature (RT). The TE performance of CuI nanoparticles (NPs) is found to be further enhanced by appropriate Al‐doping through reducing the particle size and simultaneously enhancing the electrical conductivity by a factor of 10. Al‐doping manifests to enlarge the deviation from stoichiometric composition, namely δ in Cu1‐δI, and can further assist co‐doping of iodine to generate carrier holes. The thermal conductivity is also reduced by Al‐doping and overall, the figure of merit increases from 0.01 for the pure CuI nanocrystals to ≈0.12 at 300 K and ≈0.2 at 385 K, respectively, for the 0.23 mol% Al‐doped NPs. The power generation characteristics of a single leg TE module made up of the 0.23 mol% Al‐doped CuI measured under real‐time conditions firmly indicate its suitability as a TE generator operating near RT.
Peri‐operative management of an adult with POLG‐related mitochondrial disease
Authors: Valent A. , Delorme L. , Roland E. , Lambe C. , Sarnacki S. , Cattan P. , Plaud B. 
Published: March 2022

SummaryPOLG‐related mitochondrial disease is a rare mitochondrial disorder that is potentially associated with anaesthetic complications such as propofol‐related infusion syndrome. A 19‐year‐old man with mitochondrial DNA deletions and POLG‐related disorders presented for an elective robotic Heller‐Dor myotomy for the treatment of oesophageal pseudo‐achalasia associated with severe gastro‐oesophageal reflux. The fasting period was minimised to reduce the risk of metabolic stress. The anaesthetic technique included a rapid sequence induction with propofol and rocuronium, a remifentanil and sevoflurane‐based general anaesthesia with multimodal monitoring and peri‐operative lactate‐free intravenous fluids with added dextrose. The patient did not experience propofol‐related infusion syndrome but did have delayed tracheal extubation due to residual neuromuscular blockade requiring a second dose of sugammadex. This report demonstrates the safety of single‐use, low‐dose propofol in this patient group. Patients with POLG‐related mitochondrial disease may be at risk of prolonged neuromuscular blockade, and appropriate dosing of neuromuscular blocking agents with monitoring of neuromuscular blockade is strongly encouraged.
Biosynthesis of ZrO2for ZrO2@Ag‐S‐CH2COOH as the retrievable catalyst for the one‐pot green synthesis of pyrazoline derivatives and their anticancer evaluation
Authors: Gurav Rutikesh Pandit , Nalawade Rohit Dattatray , Sawant Shivaji Dnyandeo , Satyanarayan Nayak Devappa , Sankpal Sandeep Ashok , Hangirgekar Shankar Poshatti 
Published: March 2022

AbstractIn the present work,Ficus benghalensisleaf extract was used for the synthesis of ZrO2nanoparticles. Further, ZrO2@Ag‐S‐CH2‐COOH was synthesized using biosynthesized ZrO2, and its catalytic potential was examined in the synthesis of pyrazoline from reaction of chalcone and hydrazine hydrate at room temperature. The structural conformation of ZrO2@Ag‐S‐CH2‐COOH has been done using FT‐IR, SEM, EDX, XRD, TGA‐TDA, XPS, and DLS techniques, high turnover number (TON), and high turnover frequency. The ZrO2@Ag‐S‐CH2‐COOH demonstrated outstanding catalytic activity for the synthesis of pyrazolines. The structures of the pyrazoline derivatives were confirmed by FT‐IR,1H and13C NMR, and mass spectrometry techniques. Synthesized pyrazoline were tested for anticancer activity against human lung cancer cell line A549 study and confirmed by molecular docking investigations.
Mycobiome detection from a single subterranean gametophyte using metabarcoding techniques
Authors: Chen Ko‐Hsuan , Xie Qiao‐Yi , Chang Chiung‐Chih , Kuo Li‐Yaung 
Published: March 2022

AbstractPremiseSeveral ferns and lycophytes produce subterranean gametophytes, including the Ophioglossaceae, Psilotaceae, and some members of the Schizaeaceae, Gleicheniaceae, and Lycopodiaceae. Despite the surge in plant‐microbiome research, which has been particularly boosted by high‐throughput sequencing techniques, the microbiomes of these inconspicuous fern gametophytes have rarely been examined. The subterranean gametophytes are peculiar due to their achlorophyllous nature, which makes them rely on fungi to obtain nutrients. Furthermore, the factors that shape the fungal communities (mycobiomes) of fern gametophytes have not been examined in depth.Methods and ResultsWe present a workflow to study the mycobiome of the achlorophyllous gametophytes of Ophioderma pendulum using a high‐throughput metabarcoding approach. Simultaneously, each gametophyte was investigated microscopically to detect fungal structures. Two primer sets of the nuclear ITS sequence targeting general fungi were applied, in addition to a primer set that specifically targets the nuclear small subunit ribosomal rDNA region of arbuscular mycorrhizal fungi. Both the microscopic and metabarcoding approaches revealed many diverse fungi inhabiting a single gametophyte of O. pendulum.DiscussionThis study provides methodological details and discusses precautions for the mycobiome investigation of achlorophyllous gametophytes. This research is also the first to uncover the mycobiome assembly of an achlorophyllous gametophyte of an epiphytic fern.
Bioactive constituents of Iris hybrida (Iridaceae): Processing effect
Authors: Мykhailenko Olha , Chetvernya Sergiy , Bezruk Ivan , Buydin Yrii , Dhurenko Nadija , Рalamarchuk Olena , Ivanauskas Liudas , Georgiyants Victoriya 
Published: March 2022

AbstractIris genus plants are a valuable source of bioactive compounds, which are an important component for pharmaceutical development. The present article shows the potential for mineral nutrition with application of magnesium sulfate, iron chelates and potassium oxide affecting the phenolic compound contents in Iris hybrida ‘Tsikavynka’, I. hybrida ‘Tambo’ and I. hybridа ‘Widecombe Fire’. The effect of mineral processing was specific to plant organs and varied in the component composition. The Iris rhizomes had an increased total phenolic compound content after treatment (up to 10% of the total isoflavonoid content, up to 8% of phenolic acids, up to 5% of γ‐pyrones and up to 13% of flavonoids), determined using UV–vis spectroscopy. A positive effect of nutrition on the biosynthesis and content of individual isoflavonoids (tectoridin, nigricin d‐glucoside, genistin, iristectorigenin B, nigricin, irigenin and irisolidone) and xanthone mangiferin in Iris rhizomes by HPLC was established. In addition, an increase in the chlorogenic acid amount in Iris leaves was noted. The results demonstrate the sensitivity of Iris phenylpropanoid metabolism to mineral nutrition and can be used to predict medical plant cultivation with increased content of bioactive constituents.
A “conversion‐deterioration‐double mutation” theory for the evolution and progression of colorectal cancer
Authors: Wang Rui , Yan Zhaopeng 
Published: March 2022

AbstractIn this study, based on some clinical phenomena and recently published knowledge, we proposed our “conversion‐deterioration‐double mutation” theory, which provides a possible unifying explanation for the evolutionary process of colorectal cancer cells in the human body. In this theory, we proposed that there is a partial interconversion and a jump conversion relationship among normal colorectal epithelial cells, colorectal cancer cells, stem cells, and cancer stem cells (conversion). This conversion leads to tumor heterogeneity. We also proposed that well‐differentiated cancer cells converted from cancer stem cells have a more aggressive pattern than primary cancer cells (deterioration). The deterioration of primary cancer cells leads to differences in treatment responses and prognosis. Finally, we speculate a double mutation theory, indicating that for metastasis to occur, both mutations of cancer cells and mutations of target organs are needed and should match and meet. All these three points constitute the “conversion‐deterioration‐double mutation” theory.
Paracentral acute middle maculopathy and COVID‐19 vaccination: Causation versus coincidence finding
Authors: Dehghani Alireza , Ghanbari Heshmatollah , Houshang‐Jahromi Mohammad‐hossein , Pourazizi Mohsen 
Published: March 2022

AbstractThe current report is a rare case of paracentral acute middle maculopathy (PAMM) in a previously healthy man following COVID‐19 vaccination.
Genome‐wide analysis of mRNA and microRNA expression in colorectal cancer and adjacent normal mucosa
Authors: Ito Yuma , Osakabe Mitsumasa , Niinuma Takeshi , Uesugi Noriyuki , Sugimoto Ryo , Yanagawa Naoki , Otsuka Koki , Sasaki Akira , Matsumoto Takayuki , Suzuki Hiromu , Sugai Tamotsu 
Published: March 2022

AbstractmRNA expression varies in human cancers. Such altered mRNA expression is negatively regulated by the expression of microRNAs (miRNAs), which play an important role in human tumorigenesis. According to this theory, inverse mRNA/miRNA expression may be a direct driver of cancer development, and certain genetic events may occur prior to the development of any discernible histological abnormalities. We examined the inverse expression between mRNAs and their corresponding miRNAs in colorectal cancer (CRC) and adjacent normal mucosa and performed pathway analysis to identify mRNA/miRNA networks. The cancer samples were divided into first (20 cases) and second (24 cases) cohorts, and 48 samples were obtained from two sections of the normal mucosa adjacent to the tumors from the second cohort. We investigated mRNAs with commonly altered expression in CRC and adjacent normal mucosa using isolated cancer glands and normal crypts from the first cohort, compared with that of distal normal crypts, using an array‐based method. As a result, significant inverse correlations between CEACAM1 and miRNA‐7114‐5p and between AK1 and miRNA‐6780‐5p were found in CRC and adjacent normal mucosa. We validated these correlations in the second cohort using RT‐PCR. To confirm these findings, transfection and immunohistochemical assays were also performed, which verified the inverse correlation between CEACAM1 and miRNA‐7114‐5p. Our findings suggest that the inverse correlations between the CEACAM1/miRNA‐7114‐5p and possibly AK1/miRNA‐6780‐5p pairs play an important role in early CRC development, and may help identify potential molecular targets for early detection of CRC.
On‐chip microfluidic buffer swap of biological samples in‐line with downstream dielectrophoresis
Authors: Huang Xuhai , Torres‐Castro Karina , Varhue Walter , Rane Aditya , Rasin Ahmed , Swami Nathan S. 
Published: March 2022

AbstractMicrofluidic cell enrichment by dielectrophoresis, based on biophysical and electrophysiology phenotypes, requires that cells be resuspended from their physiological media into a lower conductivity buffer for enhancing force fields and enabling the dielectric contrast needed for separation. To ensure that sensitive cells are not subject to centrifugation for resuspension and spend minimal time outside of their culture media, we present an on‐chip microfluidic strategy for swapping cells into media tailored for dielectrophoresis. This strategy transfers cells from physiological media into a 100‐fold lower conductivity media by using tangential flows of low media conductivity at 200‐fold higher flow rate versus sample flow to promote ion diffusion over the length of a straight channel architecture that maintains laminarity of the flow‐focused sample and minimizes cell dispersion across streamlines. Serpentine channels are used downstream from the flow‐focusing region to modulate hydrodynamic resistance of the central sample outlet versus flanking outlets that remove excess buffer, so that cell streamlines are collected in the exchanged buffer with minimal dilution in cell numbers and at flow rates that support dielectrophoresis. We envision integration of this on‐chip sample preparation platform prior to or post‐dielectrophoresis, in‐line with on‐chip monitoring of the outlet sample for metrics of media conductivity, cell velocity, cell viability, cell position, and collected cell numbers, so that the cell flow rate and streamlines can be tailored for enabling dielectrophoretic separations from heterogeneous samples.
Mechanochemical dechlorination of petrochemical sludge through a planetary ball mill and using industrial wastes as additives
Authors: Alavi Nadali , Adabi Shervin , Sadani Mohsen , Eslami Akbar , Amini Mostafa M. 
Published: March 2022

AbstractMechanochemical treatment causes the formation of mineral Cl compounds during the degradation of polychlorinated compounds by planetary ball mill. In the present study, the three types of industrial waste comprising of sludge from petrochemical wastewater treatment plants as source of pollutants, scrap iron and petrochemical water treatment plant sludge as co‐milling reagents were used. The raw samples and the milled products were analyzed by gas chromatography–mass spectrometry, Fourier transform infrared spectroscopy, Raman Spectroscopy, and X‐ray diffraction. Further analyses such as ion chromatography and X‐ray fluorescence were performed. The analysis results confirmed that the milling process degraded persistent organic pollutants and showed that major changes occurred in the organic phases, carbon and chlorine bonds. The yield of chloride ions was investigated using Ion Chromatography. The highest percentage of de‐Cl products (95.6%) was achieved after 6 h in equal proportions of reagents. Furthermore, CaCl2 and FeCl2 were present in the final milling product.