bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intensity-Modulated Radiation Therapy Reduces Patient-Reported Chronic Toxicity Compared With Conventional Pelvic Radiation Therapy: Updated Results of a Phase III Trial
Authors: Yeung Anamaria R. , Deshmukh Snehal , Klopp Ann H. , Gil Karen M. , Wenzel Lari , Westin Shannon N. , Konski Andre A. , Gaffney David K. , Small William , Thompson J. Spencer , Doncals Desiree E. , Cantuaria Guilherme H.C. , D'Souza David P. , Chang Amy , Kundapur Vijayananda , Mohan Dasarahally S. , Haas Michael L. , Kim Yong Bae , Ferguson Catherine L. , Pugh Stephanie L. , Kachnic Lisa A. , Bruner Deborah W. 
Published: August 2022

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned coprimary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. The purpose of this update was to determine differences in patient-reported chronic toxicity and disease outcomes with intensity-modulated radiation therapy (IMRT) compared with conventional pelvic radiation. Patients with cervical and endometrial cancers who received postoperative pelvic radiation were randomly assigned to conventional radiation therapy (CRT) or IMRT. Toxicity and quality of life were assessed using Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events, Expanded Prostate Cancer Index Composite (EPIC) bowel and urinary domains, and Functional Assessment of Cancer Therapy–General. Between 2012 and 2015, 279 eligible patients were enrolled to the study with a median follow-up of 37.8 months. There were no differences in overall survival ( P = .53), disease-free survival ( P = .21), or locoregional failure ( P = .81). One year after RT, patients in the CRT arm experienced more high-level diarrhea frequency (5.8% IMRT v 15.1% CRT, P = .042) and a greater number had to take antidiarrheal medication two or more times a day (1.2% IMRT v 8.6% CRT, P = .036). At 3 years, women in the CRT arm reported a decline in urinary function, whereas the IMRT arm continued to improve (mean change in EPIC urinary score = 0.5, standard deviation = 13.0, IMRT v –6.0, standard deviation = 14.3, CRT, P = .005). In conclusion, IMRT reduces patient-reported chronic GI and urinary toxicity with no difference in treatment efficacy at 3 years.
Single-field slow-roll effective potential from Kähler moduli stabilizations in type-IIB/F-theory
Authors: Let Abhijit , Sarkar Arunoday , Sarkar Chitrak , Ghosh Buddhadeb 
Published: August 2022

Abstract
We derive a single-field slow-roll inflaton potential in three-intersecting-D7-branes configuration under type-IIB/F-theory compactification. Among three resulting Kähler moduli corresponding to three orthogonal directions, two are stabilized via perturbative corrections in the Kähler potential arising from the large-volume scenario

and four-graviton scattering amplitude up to one loop level and the remaining Kähler modulus is stabilized by KKLT-type non-perturbative correction in superpotential. The symmetric combination of two canonically normalized and perturbatively stabilized Kähler moduli gives the inflaton field and the anti-symmetric combination manifests itself as an auxiliary field.
Salivary Steroid Collection in Children Under Conditions Replicating Home Sampling
Authors: Tonge Joseph J , Keevil Brian G , Craig Jessica N , Whitaker Martin J , Ross Richard J , Elder Charlotte J 
Published: August 2022

Abstract

Context
Measurement of salivary glucocorticoids is an accepted method for testing adrenal function but there are few data on stability during home collection. Current salivary collection techniques require active participation or present a choking hazard and are unsuitable for young children.

Objective
We sought to compare different salivary collection methods; assess the stability of salivary glucocorticoids under conditions replicating home collection; and assess patient tolerability and caregiver acceptability of a salivary collection device for young children, a swab encased in an infant pacifier (SaliPac).

Methods
Six healthy adults collected salivary samples using a Salivette Cortisol, passive drool, and SalivaBio at night, waking, and 3 Pm for five days. Time to collect 1-mL saliva using the SalivaBio and SaliPac and caregiver acceptability were assessed in 30 children younger than 6 years. Saliva was stored at 4 °C, room temperature (RT), and 50 °C for 24, 48, 72 hours and 1 week to replicate potential postage conditions. Salivary cortisol and cortisone concentrations were measured by mass spectrometry.

Results
There was no difference in salivary glucocorticoid concentrations using the 3 collection methods. Salivary cortisol and cortisone were stable for 72 hours at RT and 4 °C, and repeated freeze-thaw cycles did not cause significant degradation. In children younger than 6 years the SalivaBio and SaliPac were well tolerated and collected sufficient saliva for salivary steroid analysis in less than 4 minutes.

Conclusion
Salivette, passive drool, and SalivaBio collect samples with comparable salivary cortisol and cortisone concentrations, which are stable under conditions replicating home collection. SaliPac is an acceptable device for salivary sampling in young children.
Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells
Authors: Lin Yeu-Farn , Schang Gauthier , Buddle Evan R S , Schultz Hailey , Willis Thea L , Ruf-Zamojski Frederique , Zamojski Michel , Mendelev Natalia , Boehm Ulrich , Sealfon Stuart C , Andoniadou Cynthia L , Bernard Daniel J 
Published: August 2022

Abstract
The inhibins control reproduction by suppressing follicle-stimulating hormone synthesis in pituitary gonadotrope cells. The newly discovered inhibin B coreceptor, TGFBR3L, is selectively and highly expressed in gonadotropes in both mice and humans. Here, we describe our initial characterization of mechanisms controlling cell-specific Tgfbr3l/TGFBR3L transcription. We identified two steroidogenic factor 1 (SF-1 or NR5A1) cis-elements in the proximal Tgfbr3l promoter in mice. SF-1 induction of murine Tgfbr3l promoter–reporter activity was inhibited by mutations in one or both sites in heterologous cells. In homologous cells, mutation of these cis-elements or depletion of endogenous SF-1 similarly decreased reporter activity. We observed nearly identical results when using a human TGFBR3L promoter–reporter. The Tgfbr3l gene was tightly compacted and Tgfbr3l mRNA expression was essentially absent in gonadotropes of SF-1 (Nr5a1) conditional knockout mice. During murine embryonic development, Tgfbr3l precedes Nr5a1 expression, though the two transcripts are fully colocalized by embryonic day 18.5 and thereafter. Collectively, these data indicate that SF-1 directly regulates Tgfbr3l/TGFBR3L transcription and is required for postnatal expression of the gene in gonadotropes.
The impact of stress and its influencing factors among dentists during the COVID-19 pandemic in Kingdom of Bahrain
Authors: Ateeq Ali , Ebrahim Shaikha , Al-Ghatam Rana 
Published: August 2022

Background: It is well known that all medical professions are linked to work stress, including dentistry, which is seen as facing high risk due to the nature of the job, especially the working conditions. This study aimed to assess the impact of stress and its influencing factors among dentists during the coronavirus disease 2019 (COVID-19) pandemic in Bahrain. Methods: A cross-sectional survey was designed to assess the impact of stress and its influencing factors among Bahraini dentists. A total of 306 participants were randomly selected from 1489 registered professionals in the NHRA (National Health Regulatory Authority Bahrain). Results: Out of 306 participants invited in the survey, 253 responded. Overall, the participants reported moderate stress. All the variables of the study showed different effects, but the highest stressor with a strong correlation was “fear of social isolation” (FI) at the significance level of 0.01 (β= 0.393, t= 5.090, p < 0.05= (0.000) with f2 = 0.201 above 0.15 and less than 0.35, which was considered as a moderate effect size of approximately (20%), which strongly supported the hypothesis that researchers have proposed. Overall, the total effect for all stressors was 30 % which was considered as a moderate effect size. All hypotheses were supported except Burden of caring for patients → OUTCOME due to insufficient evidence. R² values of independent variables were above 95% for the variance of dentists’ outcomes, which is considered an excellent fit to the data as evidenced by the squared multiple correlations (R2 ) values for the dependent variables. Conclusions: The study is unique based on its findings that reveal the impact of stress among dentists. Moreover, the results of this study may serve as guidance for future monitoring of dental practitioners’ burnout, anxiety, and workload.
Optimization Strategies for Resource-Constrained Project Scheduling Problems in Underground Mining
Authors: Hill Alessandro , Brickey Andrea J. , Cipriano Italo , Goycoolea Marcos , Newman Alexandra 
Published: August 2022

Effective computational methods are important for practitioners and researchers working in strategic underground mine planning. We consider a class of problems that can be modeled as a resource-constrained project scheduling problem with optional activities; the objective maximizes net present value. We provide a computational review of math programming and constraint programming techniques for this problem, describe and implement novel problem-size reductions, and introduce an aggregated linear program that guides a list scheduling algorithm running over unaggregated instances. Practical, large-scale planning problems cannot be processed using standard optimization approaches. However, our strategies allow us to solve them to within about 5% of optimality in several hours, even for the most difficult instances. History: Accepted by Andrea Lodi, Area Editor for Design and Analysis of Algorithms—Discrete. Funding: This work was supported by Alford Mining Systems, the Centro de Modelamiento Matemático [Grants ACE210010 and FB21005], ANID-Chile [BASAL funds for center of excellence and FONDEF Grant ID19-10164], and the supercomputing infrastructure of the NLHPC [Grant ECM-02].
Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of the medically most important Bitis spp. and Echis spp. African snakes
Authors: Gómez Aarón , Sánchez Andrés , Durán Gina , Cordero Daniel , Segura Álvaro , Vargas Mariángela , Solano Daniela , Herrera María , Chaves-Araya Stephanie , Villalta Mauren , Sánchez Melvin , Arguedas Mauricio , Díaz Cecilia , Gutiérrez José María , León Guillermo 
Published: August 2022

Background
Snakebite envenomation exerts a heavy toll in sub-Saharan Africa. The design and production of effective polyspecific antivenoms for this region demand a better understanding of the immunological characteristics of the different venoms from the most medically important snakes, to select the most appropriate venom combinations for generating antivenoms of wide neutralizing scope. Bitis spp. and Echis spp. represent the most important viperid snake genera in Africa.

Methodology/Principal findings
Eight rabbit-derived monospecific antisera were raised against the venoms of four species of Bitis spp. and four species of Echis spp. The effects of immunization in the rabbits were assessed, as well as the development of antibody titers, as judged by immunochemical assays and neutralization of lethal, hemorrhagic, and in vitro coagulant effects. At the end of immunizations, local and pulmonary hemorrhage, together with slight increments in the plasma activity of creatine kinase (CK), were observed owing to the action of hemorrhagic and myotoxic venom components. Immunologic analyses revealed a considerable extent of cross-reactivity of monospecific antisera against heterologous venoms within each genus, although some antisera provided a more extensive cross-reactivity than others. The venoms that generated antisera with the broadest coverage were those of Bitis gabonica and B. rhinoceros within Bitis spp. and Echis leucogaster within Echis spp.

Conclusions/Significance
The methodology followed in this study provides a rational basis for the selection of the best combination of venoms for generating antivenoms of high cross-reactivity against viperid venoms in sub-Saharan Africa. Results suggest that the venoms of B. gabonica, B. rhinoceros, and E. leucogaster generate antisera with the broadest cross-reactivity within their genera. These experimental results in rabbits need to be translated to large animals used in antivenom production to assess whether these predictions are reproduced in horses or sheep.
The prevalence of self-reported anxiety, depression, and associated factors among Hanoi Medical University’s students during the first wave of COVID-19 pandemic
Authors: Nguyen Dat Tien , Ngo Tri Minh , Nguyen Huong Lan Thi , Le Minh Dai , Duong Mai Le Ngoc , Hoang Phan Huy , Nguyen Ha Viet , Foster Kirsty , Duong Tuyen Van , Kim Giang Bao , Pham Tung Thanh 
Published: August 2022

Background
Medical students are known to have higher levels of these issues than the general population but in Vietnam the effects of the pandemic on medical student mental health was not documented.

Objectives
To estimate the prevalence and identify factors associated with self-reported anxiety disorder, depression, and perception of worsening mental health among Vietnamese medical students during the COVID-19 pandemic.

Method
A cross-sectional study was conducted from April 7th to 29th, 2020. All students in Doctor of General Medicine, Doctor of Preventive Medicine, and Bachelor of Nursing tracks at Hanoi Medical University (3672 students) were invited to participate. Data were collected using an online questionnaire including demographic characteristics, Generalized Anxiety Disorder 7 items, Patient Health Questionnaire 9 items, Fear of COVID-19 scale, and question about worsening mental health status. Robust Poisson regression was used to assess the association between mental health status and associated factors.

Results
Among 1583 students (43.1% response rate), the prevalence of students screened positive for anxiety disorder was 7.3%(95%C.I.:6.0–8.7), depression was 14.5%(95%C.I.:12.8–16.3), and perceiving worsening mental health was 6.9%(95%C.I.:5.7–8.3). In multivariable regression models, significant factors associated with self-reported anxiety disorder included being male (PR = 1.99,95%C.I.:1.35–2.92), difficulty in paying for healthcare services (PR = 2.05,95%C.I.:1.39–3.01), and high level of fear of COVID-19 (Q3:PR = 2.36,95%C.I.:1.38–4.02 and Q4:PR = 4.75,95%C.I.:2.65–8.49). Significant factors associated with self-reported depression were difficulty in paying for healthcare services (PR = 1.78,95%C.I.:1.37–2.30), and high level of fear of COVID-19 (Q3:PR = 1.41,95%C.I.:1.02–1.95 and Q4:PR = 2.23,95%C.I.:1.51–3.29). Significant factors associated with perceived worsening mental health status included having clinical experience (PR = 1.83,95%C.I.:1.17–2.88) and having atypical symptoms of COVID-19 (PR = 1.96,95%C.I.:1.31–2.94).

Conclusion
The prevalence of self-reported depression, anxiety disorder, and worsening mental health among Vietnamese students during the first wave of COVID-19 was lower than in medical students in other countries. Further investigation is needed to confirm this finding.
Cross-sectional associations of physical frailty with fall, multiple falls and fall-injury among older Indian adults: Findings from LASI, 2018
Authors: Thakkar Shriya , T. Muhammad , Srivastava Shobhit 
Published: August 2022

BackgroundAlthough there has been a range of studies that focused on physical frailty and associated fall outcomes within developed countries, similar studies from developing countries have been limited. This study aimed to examine the relationship between physical frailty and the prevalence of falls, multiple falls and fall-related injuries among the ageing population within the Indian context.MethodsIndividual-level data from the first wave of the Longitudinal Aging Study in India (LASI) with 28,285 older adults aged 60 years and above (male 48.9%) was used for this study. Physical frailty was assessed through the physical frailty phenotype adapted from Fried’s criteria. Multivariable logistic regression was employed to examine the association of frailty status with falls, multiple falls, and fall-related injuries among Indian older adults.ResultsThe prevalence of frailty was found to be 29.94% within the sample and frail older adults had a higher prevalence of falls (15.43% vs 11.85%), multiple falls (7.73% vs 5.25%), and fall related injuries (6.68% vs 5.29%). The odds of falling among frail older adults were significantly higher in reference to the odds of falling among non-frail older adults [aOR: 1.24; CI: 1.09–1.41]. Similarly, the odds of multiple falls among frail older adults were significantly higher in reference to the odds of multiple falls among non-frail older adults [aOR: 1.24; CI: 1.05–1.48]. Moreover, the odds of fall-related injury among frail older adults were significantly higher in reference to the odds of fall-related injury among non-frail older adults [aOR: 1.21; CI: 1.01–1.45]. Falls, multiple falls and fall-related injuries were found to be significantly associated with employment and poor self-rated health, whereas, females and lone living older adults had a significantly higher likelihood of suffering from falls and multiple falls.ConclusionOlder individuals with physical frailty were found to be at increased risk of falls, multiple falls and fall-related injuries in India. The findings of our study also have important clinical implications in the measures undertaken to reduce falls and enable future healthcare practitioners and policymakers to factor in the key determinant of physical frailty.
COVID-19 vaccine acceptance among healthcare workers in China: A systematic review and meta-analysis
Authors: Shui Xiaoling , Wang Fang , Li Ling , Liang Qian 
Published: August 2022

Background
Since the successful development of Coronavirus Disease (COVID-19) vaccine, COVID-19 vaccination has been actively advocated all over the world. As the key population for COVID-19 vaccination, the acceptance of Healthcare Workers (HCWs) is not only related to their risk of contracting COVID-19 infection at work, but also affects the decision of the general population on COVID-19 vaccination. Currently, a series of observational studies have been conducted on the acceptance of COVID-19 vaccines among HCWs in China, but there are presently no all-inclusive reviews. Therefore, this paper reviewed to identify a reliable estimate of acceptance rate of COVID-19 vaccine among HCWs in China.

Methods
We conducted a search on PubMed, EMbase, The Cochrane Library, Web of Science, CNKI (Chinese National Knowledge Infrastructure), Wanfang Database, CBM (Chinese Biomedical Literature Database) and VIP database (Chinese Scientific Journal Database) from January 2020 to June 2022. The quality of included articles was estimated using the Newcastle-Ottawa Quality Assessment tool suitable for cross-sectional studies and STATA 16 was used for analysis, A random-effects model was used to calculate acceptance rate for COVID-19 vaccine, as well as subgroup analysis and sensitivity analysis.

Result
This review included 18 studies involving 45,760 subjects, all of which were of medium or high quality. Meta-analysis results represented that, the pooled estimated acceptance rate of COVID-19 vaccine among HCWs in China was 78% (95%CI: 73–83%), and the pooled acceptance rate in 2021 (82%, 95%CI: 78–86%) was significantly higher than that in 2020 (73%, 95%CI: 65%-81%). Subgroup analysis showed different acceptance rates for COVID-19 vaccine among HCWs with different characteristics.

Conclusion
The result revealed that HCWs in China generally have a high acceptance rate of COVID-19 vaccines, but the acceptance rate varies with different characteristics of the population. Therefore, corresponding training should be carried out for HCWs with different characteristics, and they should play an exemplary and leading role in COVID-19 vaccination, so as to improve the vaccination rate of the whole population and form an immune barrier at an early date.
Control externo de la calidad en medicina del laboratorio. Avances y futuro
Authors: Ricós Carmen , Fernández-Calle Pilar , Perich Carmen , Sandberg Sverre 
Published: August 2022

Resumen

Objectivos
Un programa de control externo distribuye las mismas muestras control entre varios laboratorios y evalúa los resultados obtenidos con un criterio común. El objetivo de este trabajo es resumir la evolución de los programas externos, poner de manifiesto los progresos conseguidos y deducir consecuencias prácticas para el laboratorio participante.

Métodos
El material es una breve revisión de los diferentes tipos de programas externos utilizados a lo largo de cuarenta años. El método es el análisis crítico de las ventajas e inconvenientes de cada modelo, a la luz de nuestra experiencia.

Resultados
A mitad del siglo XX se iniciaron los programas EQA, detectándose gran discrepancia entre resultados emitidos por distintos laboratorios. Se desarrollaron EQA en muchos países y se propusieron mecanismos para armonizarlos, como: establecer especificaciones derivadas de la variación biológica, promover el uso de métodos analíticos homogéneos, usar el EQA como herramienta educacional. A partir del 2000 se hacen importantes avances: asegurar el adecuado uso clínico de las pruebas del laboratorio, utilizar material control conmutable con el espécimen humano, armonizar los distintos modelos de EQA, promover una organización de cooperación entre organizadores de programas EQA.

Conclusiones
Participar en un EQA con controles conmutables y valores asignados por método de referencia certificado permite conocer la inexactitud real de los resultados y el impacto en las muestras de pacientes. Si se participa en programas con controles no conmutables solo se conoce si la prestación del laboratorio es similar a la de otros usuarios del mismo método analítico.
Biomagnetic signals recorded during transcranial magnetic stimulation (TMS)-evoked peripheral muscular activity
Authors: Iwata Geoffrey Z. , Hu Yinan , Wickenbrock Arne , Sander Tilmann , Muthuraman Muthuraman , Chirumamilla Venkata Chaitanya , Groppa Sergiu , Liu Qishan , Budker Dmitry 
Published: August 2022

Abstract
Transcranial magnetic stimulation (TMS) has widespread clinical applications from diagnosis to treatment. We combined TMS with non-contact magnetic detection of TMS-evoked muscle activity in peripheral limbs to explore a new diagnostic modality that enhances the utility of TMS as a clinical tool by leveraging technological advances in magnetometry. We recorded measurements in a regular hospital room using an array of optically pumped magnetometers (OPMs) inside a portable shield that encloses only the forearm and hand of the subject. We present magnetomyograms (MMG)s of TMS-evoked movement in a human hand, together with a simultaneous surface electromyograph (EMG) data. The biomagnetic signals recorded in the MMG provides detailed spatial and temporal information that is complementary to that of the electric signal channels. Moreover, we identify features in the magnetic recording beyond that of the EMG. This system demonstrates the value of biomagnetic signals in TMS-based clinical approaches and widens its availability and practical potential.