bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KEGIATAN SEKTOR EKONOMI TERHADAP KINERJA LALU LINTAS DI RUAS JALAN KELURAHAN VIM DISTRIK ABEPURA (Studi Kasus: Ruas Jalan Perkutut, Mako Brimob – Kantor Pos Kotaraja)
Authors: Muhammad Bayu Kholil Abdusalam  , Monita Yessy Beatrick  , Sudiro Sudiro  
Published: November 2022

Economic activity becomes a benchmark in the assessment of the community to achieve prosperity, and becomes a supporter and driver of growth in the surrounding area. Vim Village, Abepura District is one of the service activity centers that has a land use that is so complex and strategically located that it triggers various forms of economic activity, becoming an attraction for people to travel for transportation, especially along Jalan Perkutut. This study examines the relationship of micro-economic activities with traffic performance obtained from side barriers, vehicle volume and road capacity. The research methods used to achieve the objectives are quantitative methods and qualitative methods. The quantitative method uses the analysis of the Indonesian Road Capacity Manual (MKJI, 1997) to obtain vehicle volume, road capacity and traffic performance. The qualitative method uses descriptive analysis that discusses the comparison of the distribution of micro-economic activities that affect side barriers, the comparison of two traffic performance results and spatial planning plans along the Perkutut road.
The results showed that the increase in the number of micro-economic activities at night along Jalan Perkutut had an effect on increasing the number of side barriers and the volume of vehicles. In addition, the imbalance in the volume of vehicles and road capacity shows that Perkutut Road traffic performance is experiencing congestion as indicated by the Service Level Index (ITP) with a value of F. Under these conditions, spatial planning for the road network, pedestrian pedestrian arrangement and land use arrangement is needed, especially on microeconomic activities.
PENGARUH KOMUNIKASI ANTARA GURU DAN SISWA TERHADAP MOTIVASI BELAJAR SISWA KELAS V DI SDN 1 PAKU KECAMATAN BOLANGITAN BARAT
Authors: Lasompo Nurianti , Nadjamuddin Asriyati 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh yang dihasilkan Komunikasi Antara Guru dan Siswa Terhadap Motivasi Belajar Siswa. Penelitian ini menggunakan jenis penelitian kuantitatif dengan desain korelasional untuk mendapatkan informasi yang lengkap dan mendalam mengenai pengaruh Komunikasi antara Guru dan Siswa terhadap motivasi belajar siswa kelas V di SDN 1 Paku Kecamatan Bolangitan Barat. Populasi dalam penelitian ini berjumlah 30 orang, sehingga penelitian ini dikatakan sebagai penelitian populasi. Selanjutnya pengumpulan data menggunakan angket, dan jenis analisis data yang digunakan yaitu uji normalitas data, uji korelasi dan uji hipotesis dengan menggunakan uji t. Hasil penelitian menunjukkan bahwa setelah melakukan uji-t, diperoleh nilai thitung sebesar 50.014 dan nilai ttabel sebesar 2.080, selanjutnya nilai signifikansi sebesar 0.000 (ρ < 0.05). Hal itu berarti semakin baik tingkat komunikasi antara Guru dan Siswa maka semakin tinggi Motivasi Belajar Siswa kelas V di SDN 1 Paku Kecamatan Bolangitan Barat.
Strengthen Standards to Improve Early Childhood Development in Humanitarian Crises
Authors: Bassett Lucy , Bradley J. Charles 
Published: November 2022

Substantial evidence across disciplines indicates that children’s early years are critical for building the foundation for optimal development. In contexts of crisis, conflict, disaster and displacement, children are at particular risk. Primary caregivers often have fewer resources and less time to provide children with attention and necessary socio-emotional and cognitive stimulation. Risk factors for children are often multiplied in crises and conflict settings, and access to services becomes more challenging where family and social networks have been weakened and social service delivery interrupted.
To address the needs of young children, we must strengthen humanitarian response. Practitioners often use humanitarian standards and guidance to systematise planning, implementation and evaluation of programming. These documents describe the broad principles and essential elements (i.e. specific benchmarks and actions) for high-quality response, reflecting best practices at a global level.
We analysed the degree to which existing humanitarian standards and guidance documents explicitly recognise young children and their caregivers in humanitarian response and looked at gaps in the five areas that experts agree are essential for children’s holistic development: good health, adequate nutrition, security and safety, responsive caregiving and opportunities for early learning. We then made recommendations for achieving more comprehensive and consolidated guidance to address early childhood development in emergencies.
Diagnostic performance of circulating tumor DNA as a minimally invasive biomarker for hepatocellular carcinoma: a systematic review and meta-analysis
Authors: Li Jia Jie , Lv Yanqing , Ji Huifan 
Published: November 2022

Purpose
This study aimed to assess the diagnostic performance of circulating tumor DNA (ctDNA) in hepatocellular carcinoma (HCC).

Materials and Methods
We enrolled all relevant studies published up to 5 January 2022. Three primary subgroups were investigated: qualitative or quantitative ctDNA analyses, combined alpha-fetoprotein (AFP), and ctDNA assay. In addition to the three primary subgroups, we also evaluated the diagnostic value of methylated SEPTIN9 (mSEPT9), which has been studied extensively in the diagnosis of hepatocellular carcinoma. After a search based on four primary databases, we used a bivariate linear mixed model to analyze the pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). We also plotted hierarchical summary receiver operating characteristics (HSROC) and utilized lambda as well as the area under the curve (AUC) to create summary receiver operating characteristic (SROC) curves to estimate the diagnostic value of ctDNA.

Results
A total of 59 qualified articles with 9,766 subjects were incorporated into our meta-analysis. The integrated SEN, SPE, and DOR in the qualitative studies were 0.50 (95% CI [0.43–0.56]), 0.90 (95% CI [0.86–0.93]), and 8.72 (95% CI [6.18–12.32]), respectively, yielding an AUC of 0.78 and lambda of 1.93 (95% CI [1.56–2.33]). For quantitative studies, the corresponding values were 0.69 (95% CI [0.63–0.74]), 0.84 (95% CI [0.77–0.89]), 11.88 (95% CI [7.78–18.12]), 0.81, and 2.32 (95% CI [1.96–2.69]), respectively. Six studies were included to evaluate the SETP9 methylation, which yielded an AUC of 0.86, a SEN of 0.80 (95% CI [0.71–0.87]), and a SPE of 0.77 (95% CI [0.68–0.85]). Likewise, ctDNA concentration yielded an AUC of 0.73, with a SEN of 0.63 (95% CI [0.56–0.70]) and a SPE of 0.86 (95% CI [0.74–0.93]). AFP combined with ctDNA assay resulted in an AUC of 0.89, with a SEN of 0.82 (95% CI [0.77–0.86]) and a SPE of 0.84 (95% CI [0.76–0.90]).

Conclusion
This study shows that circulating tumor DNA, particularly mSEPT9, shows promising diagnostic potential in HCC; however, it is not enough to diagnose HCC independently, and ctDNA combined with conventional assays such as AFP can effectively improve diagnostic performance.
Comparison of Face-to-Face vs Digital Delivery of an Osteoarthritis Treatment Program for Hip or Knee Osteoarthritis
Authors: Jönsson Therese , Dell’Isola Andrea , Lohmander L. Stefan , Wagner Philippe , Cronström Anna 
Published: November 2022

ImportanceDigital care platforms have been introduced, but there is limited evidence for their efficacy compared with traditional face-to-face treatment modalities.ObjectiveTo compare mean pain reduction among individuals with osteoarthritis (OA) of the knee or hip who underwent face-to-face vs digital first-line intervention.Design, Setting, and ParticipantsThis registry-based cohort study included all persons with knee or hip osteoarthritis who participated in structured first-line treatment for osteoarthritis in a primary care setting in Sweden. Inclusion criteria were as follows: the treatment was delivered face-to-face or digitally between April 1, 2018, and December 31, 2019; patients provided 3-month follow-up data for pain; and patients had program adherence of at least 80%. Data analysis was conducted in March 2021.ExposuresParticipants completed a 3-month intervention, including education and exercise for hip or knee osteoarthritis, with program adherence of 80% or higher, delivered face-to-face or by a digital application.Main Outcomes and MeasuresDifference in change in joint pain (11-point numeric rating scale, with 0 indicating no pain and 10, the worst possible pain) between baseline and 3-month follow-up between the 2 intervention modalities. A minimal clinically important difference in pain change between groups was predefined as 1 point. Secondary outcomes were walking difficulties, health-related quality of life, willingness to undergo joint surgery, and fear avoidance behavior.ResultsA total of 6946 participants (mean [SD] age, 67 [9] years; 4952 [71%] women; 4424 [64%] knee OA; 2504 [36%] hip OA) were included, with 4237 (61%) receiving face-to-face treatment and 2709 (39%) receiving digital treatment. Both the face-to-face (mean change, −1.10 [95% CI −1.17 to −1.02] points) and digital interventions (mean change, −1.87 [95% CI, −1.94 to −1.79] points) resulted in a clinically important pain reduction at 3 months. Participants in the digitally delivered intervention experienced a larger estimated improvement at 3 months (adjusted mean difference, −0.93 [95% CI, −1.04 to −0.81] points). Results of secondary outcomes were broadly consistent with main outcome.Conclusions and RelevanceThis Swedish national registry-based cohort study showed that people with knee or hip OA participating in first-line intervention experienced clinically relevant improvements in pain, whether delivered face-to-face or digitally. The increased benefit of digital delivery compared with face-to-face delivery was of uncertain clinical importance.
Complexity and Challenges of the Clinical Diagnosis and Management of Long COVID
Authors: O’Hare Ann M. , Vig Elizabeth K. , Iwashyna Theodore J. , Fox Alexandra , Taylor Janelle S. , Viglianti Elizabeth M. , Butler Catherine R. , Vranas Kelly C. , Helfand Mark , Tuepker Anaïs , Nugent Shannon M. , Winchell Kara A. , Laundry Ryan J. , Bowling C. Barrett , Hynes Denise M. , Maciejewski Matthew L. , Bohnert Amy S. B. , Locke Emily R. , Boyko Edward J. , Ioannou George N. ,   VA COVID Observational Research Collaboratory (CORC)
Published: November 2022

ImportanceThere is increasing recognition of the long-term health effects of SARS-CoV-2 infection (sometimes called long COVID). However, little is yet known about the clinical diagnosis and management of long COVID within health systems.ObjectiveTo describe dominant themes pertaining to the clinical diagnosis and management of long COVID in the electronic health records (EHRs) of patients with a diagnostic code for this condition (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ICD-10] code U09.9).Design, Setting, and ParticipantsThis qualitative analysis used data from EHRs of a national random sample of 200 patients receiving care in the Department of Veterans Affairs (VA) with documentation of a positive result on a polymerase chain reaction (PCR) test for SARS-CoV-2 between February 27, 2020, and December 31, 2021, and an ICD-10 diagnostic code for long COVID between October 1, 2021, when the code was implemented, and March 1, 2022. Data were analyzed from February 5 to May 31, 2022.Main Outcomes and MeasuresA text word search and qualitative analysis of patients’ VA-wide EHRs was performed to identify dominant themes pertaining to the clinical diagnosis and management of long COVID.ResultsIn this qualitative analysis of documentation in the VA-wide EHR, the mean (SD) age of the 200 sampled patients at the time of their first positive PCR test result for SARS-CoV-2 in VA records was 60 (14.5) years. The sample included 173 (86.5%) men; 45 individuals (22.5%) were identified as Black and 136 individuals (68.0%) were identified as White. In qualitative analysis of documentation pertaining to long COVID in patients’ EHRs 2 dominant themes were identified: (1) clinical uncertainty, in that it was often unclear whether particular symptoms could be attributed to long COVID, given the medical complexity and functional limitations of many patients and absence of specific markers for this condition, which could lead to ongoing monitoring, diagnostic testing, and specialist referral; and (2) care fragmentation, describing how post–COVID-19 care processes were often siloed from and poorly coordinated with other aspects of care and could be burdensome to patients.Conclusions and RelevanceThis qualitative study of documentation in the VA EHR highlights the complexity of diagnosing long COVID in clinical settings and the challenges of caring for patients who have or are suspected of having this condition.
Robust Carbonaceous Nanofiber Aerogels from All Biomass Precursors
Authors: Hu Bi‐Cheng , Zhang Hao‐Ran , Li Si‐Cheng , Chen Wen‐Shuai , Wu Zhen‐Yu , Liang Hai‐Wei , Yu Hai‐Peng , Yu Shu‐Hong 
Published: November 2022

AbstractAerogels, a type of fascinating material with very low density and high surface area, show many unique properties and unlimited applications. To boost their practical applications, it is necessary to develop efficient, controllable, and low‐cost methods to produce high‐performance aerogels on a large‐scale, preferably in a sustainable way. Here, a general strategy is reported for controllable fabrication of a family of carbonaceous nanofiber aerogels (CNFAs) by biomass‐derived nanofibers template‐directed hydrothermal carbonization method. Abundant functional groups are exposed on the surface of the prepared carbonaceous nanofibers. Importantly, in contrast to traditional nature biopolymer‐based aerogels, a superior combination of good recoverability and high strength is achieved for the CNFAs by adjusting the synthetic parameters. The successful synthesis of such fascinating materials provides an excellent platform for design and construction of devices for fast water treatment. The synthetic strategy and sustainable concept presented in this work will open a new way to prepare advanced aerogels with unique properties for wide applications.
Unraveling and Overcoming Platinum Drug‐Resistant Cancer Tumors with DNA Nanostructures
Authors: Yu Yingjie , Zhang Linghao , Qin Zhaohui , Karges Johannes , Xiao Haihua , Su Xin 
Published: November 2022

AbstractAll chemotherapeutic treatments worldwide (>50%) use platinum‐based compounds. Despite their clinical success, an increasing number of platinum drug‐resistant tumors are reported, limiting the therapeutic application of these compounds. While various kinds of strategies are pursued to circumvent resistances, there remains a lack of understanding of how cancer cells develop platinum drug resistances. Within this study, the involvement of the DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) in the occurrence of platinum drug resistance is directly visualized in living cells by a DNA tetrahedron‐based molecular probe. Capitalizing on this biochemical insight, the suppression of the expression of APE1 in cancer cells is realized using a DNA tetrahedron‐based RNA interference technique, presenting a novel strategy to overcome platinum drug resistance. This study presents the first example of Pt(IV) complex loaded tumor aptamer‐modified DNA tetrahedrons with an APE1 specific small interfering RNA (siRNA) strand for suppression of APE1 expression and therapeutic treatment of patient‐derived platinum drug‐resistant lung cancer tumors.
High Cationic Dispersity Boosted Oxygen Reduction Reactivity in Multi‐Element Doped Perovskites
Authors: Li Wenhuai , Li Mengran , Guo Yanan , Hu Zhiwei , Zhou Chuan , Brand Helen E. A. , Peterson Vanessa K. , Pao Chih‐Wen , Lin Hong‐Ji , Chen Chien‐Te , Zhou Wei , Shao Zongping 
Published: November 2022

AbstractOxygen‐ion conducting perovskite oxides are important functional materials for solid oxide fuel cells and oxygen‐permeable membranes operating at high temperatures (>500 °C). Co‐doped perovskites have recently shown their potential to boost oxygen‐related kinetics, but challenges remain in understanding the underlying mechanisms. This study unveils the local cation arrangement as a new key factor controlling oxygen kinetics in perovskite oxides. By single‐ and co‐doping Nb5+ and Ta5+ into SrCoO3‐δ, dominant factors affecting oxygen kinetics, such as lattice geometry, cobalt states, and oxygen vacancies, which are confirmed by neutron and synchrotron X‐ray diffraction as well as high‐temperature X‐ray absorption spectroscopy, are controlled. The combined experimental and theoretical study unveils that co‐doping likely leads to higher cation dispersion at the B‐site compared to single‐doping. Consequently, a high‐entropy configuration enhances oxygen ion migration in the lattice, translating to improved oxygen reduction activity.
Influence of 2‐hydroxypropyltrimethyl ammonium chloride chitosan on sedimentation and volume change behavior of cohesive soil sediments
Authors: Qiu Yu , Hu Haixiang , Lu Zheng , Tang Chuxuan , Yao Hailin 
Published: November 2022

AbstractThe 2‐hydroxypropyltrimethyl ammonium chloride chitosan (HACC), introducing the functional quaternary ammonium group to the structure of Chitosan, has greatly broadened the application prospect. The influence on natural cohesive soil has rarely been considered. The sedimentation tests for the natural soil in HACC solutions and the HACC‐treated soils in distilled water are considered to analyze the change of sedimentation behaviors in this paper. Moreover, the potential change on the surface of soil particles, the change in particle size distribution, X‐ray diffraction of Ca‐montmorillonite/HACC, and scanning electron microscopy images are investigated to explain the reasons for the results. Results indicate that the surface potential of soil particles achieved reversal, and the particle size had significant agglomeration. The adsorption of HACC results in the rapid sedimentation of the treated soils in water. HACC has a significant influence on setting time and final volume. HACC cannot inhibit the interlayer swelling of Ca‐montmorillonite. The dehydration process can promote the aggregation effect of the treated soils. The specific effects provided an essential train of thought to solve soil problems.
Effect of natural biomass fillers on the stability, degradability, and elasticity of crop straws liquefied polyols‐based polyurethane foams
Authors: Zhang Jingmiao , Hori Naruhito , Takemura Akio 
Published: November 2022

AbstractOilseed rape straw (OS), rice straw (RS), wheat straw (WS), and corn stover (CS) particles were used to reinforce bio‐polyols based polyurethane (PU) foams. The influence of crop straws (XS) fillers on the stability in water, degradability in soil, thermal stability, and elasticity of foams were investigated. The incorporation of OS and CS particles in the PU matrix increased the stability of reinforced foams in water, while the addition of WS and RS particles made foams lower stability in water. PU foams reinforced by XS particles displayed mass reductions up to 53.8% after burying in soil for 250 days. The reinforced foams were more stable under heating but the enhancement of thermal stability trended to disappear after water immersion or soil burying. The reinforced foams showed better elasticity that incorporations of OS and CS made PU foams higher height recovery percentage, while RS and WS made the recovery percentage decline firstly and then enhance during three times compressions. All these four XS particles are suitable to modify bio‐based PU foams, especially OS and CS particles appear to be more outstanding in preparing foams with higher stability in water, degradability in soil, thermal stability, and elasticity than RS and WS particles.
Effect of hyperbranched poly(trimellitic glyceride)/oxidized starch composite sizing agent on the adhesion of polyester yarns
Authors: Zhang Kang , Ouyang Haishun , He Yixuan , Wang Xinquan , Lin Yi , Zhu Puxin , Cheng Fei , Tang Kewen 
Published: November 2022

AbstractOxidized starch is an environmentally friendly sizing agent, but lacks adhesion to polyester yarns. In this study, hyperbranched poly(trimellitic glyceride)/oxidized starch (PTG/OS) as the composite sizing agent is used for sizing polyester yarns. The properties of sizing film, sizing paste, and sizing yarns are studied. When PTG content ranges from 2 to 10 wt%, tensile strength of PTGs/OS films are higher than that of oxidized starch film, and increase as molecular weight of PTG increase. Tensile strength of OS, PTG‐1/OS, PTG‐2/OS, and PTG‐3/OS films with 10 wt% PTG is 20.5, 22.4, 23.8, and 27.6 MPa, respectively. Apparent viscosity and viscosity stability of PTG/OS paste increases with the increase of PTG molecular weight. Breaking force, elongation at break and work‐to‐break of sizing polyester yarns by PTG/OS increase with the increase of PTG content in composite sizing agents, and the improvement on the tensile properties of sizing polyester yarns by PTG/OS becomes better with increase of PTG molecular weight. It is attributed to the stronger affinity among oxidized starch, PTG and polyester, which is verified by FT‐IR, XPS, and SEM. Oxidized starch blended hyperbranched poly(trimellitic glyceride) has the potential application for sizing polyester yarns in weaving process.
Effect of heat‐treatment on compressive response of 3D printed continuous carbon fiber reinforced composites under different loading directions
Authors: Xiang Jiangyang , Liu Yisen , Wang Jin , Wang Kui , Peng Yong , Rao Yanni , Matadi Boumbimba Rodrigue 
Published: November 2022

AbstractThis paper investigated the effects of heat‐treatment and loading directions on compressive properties of 3D printed continuous carbon fiber reinforced composites (CCFRC). After heat‐treatment at different conditions, specimens with different stacking sequences were compressed under different loading directions. The effect of heat‐treatment on the porosity and crystallinity of composites was investigated. The porosity of short carbon fiber reinforced composites decreased but that of CCFRC increased after heat‐treatment at 200°C. The compressive properties of specimens were investigated in combination with changes in porosity and crystallinity. It was found that the compressive properties of composites usually increased with decreasing porosity induced by heat‐treatment. While the fiber direction was parallel to the applied loading direction, the yield strength of C‐CCFRC and S‐CCFRC increased from 208.1 to 281.6 MPa and from 218.5 to 264.4 MPa, respectively, though the porosity increased. After heat‐treatment at 100°C for 4 h, the crack initiation of CCFRCs was delayed during compressive tests. Besides, heat‐treatment could change failure modes of CCFRC after heat‐treatment at 200°C for 4 h. More specifically, heat‐treatment at 200°C for 4 h could result in delamination and a decrease in energy absorption of C‐CCFRC (from 7.23 to 4.05 J).