bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of technologies for selecting energy-efficient power supply circuits of railway traction networks
Authors: Domanskyi Valerii , Domanskyi Illia , Zakurdai Svitlana , Liubarskyi Dmytro 
Published: October 2022

The object of the study is the process of operation of traction and external power supply systems as objects of inextricable interconnection while reducing energy costs in the cost of railway transportation in real time. One of the most problematic areas is the technology for choosing energy-efficient power supply schemes for railway traction networks in real time. The methods of forming and transforming graphs of complex schemes of traction and external power supply systems and building expert control systems for the implementation of energy-saving technologies of electrified railways were further developed in the work.
In the course of the study, to increase the efficiency of simulation modeling of electric traction networks, the statistical characteristics of the loads of feeders that supply the final boundary sections, stations, depot access tracks, railway junctions and idle voltages on the traction substation tires were obtained. Methods of calculation and modeling of traction power supply have been developed, which take into account the inseparable relationship with power systems and allow choosing rational modes with minimal power flows and energy losses. Proposed methods of managing the modes of operation of the traction power supply system based on a vague description of their states and an expert system that allow solving new problems. Including, the choice of energy-saving power supply schemes in the case of power flows, economic modes of network operation in case of intensification of the transportation process. Thanks to this, ways of reducing power consumption and minimizing energy losses of traction power supply systems are proposed, which allow minimizing power flows and power losses by adjusting load flow parameters and voltage levels of traction substations. And also to increase the energy efficiency of electrified railway lines.
The technique of technical and economic feasibility of power supply schemes of traction networks and evaluation of the possibility of switching to cantilever or loop power supply schemes with parallel connection points has been developed. The implemented recommendations save about 25 thousand kWh per 1 km of two-track section.
Experimental and numerical study on SMA modified with an encapsulated polymeric healing agent
Authors: Inozemtcev Sergey , Jelagin Denis , Korolev Evgeniy , Fadil Hassan , Partl Manfred N. , Do Trong Toan 
Published: October 2022

AbstractThe present study aims at experimentally and numerically investigating the effect an encapsulated healing agent on the mechanical characteristics of a stone mastic asphalt (SMA). As a healing agent a thiol-containing urethane AR-polymer is used in this study. In order to gain a numerical insight into mechanical behavior of the capsules in SMA, a micromechanical finite element modeling is employed. The developed model allows capturing the stresses induced in the capsules at different load cases applied to the SMA on macro-scale. Particular attention is paid presently to the numerical evaluation of the local stress state that arises around capsules during compaction, operation, and also during crack initiation. SMA mixtures with various volumetric contents of healing capsules were manufactured and the capsules survival during mixture production was evaluated based on X-Ray Computed Tomography measurements. The effect of capsules on the self-healing properties of asphalt mixtures has furthermore been examined with repeated compressive strength tests. The obtained experimental results indicate that the absolute majority of capsules survive mixture production, and that their addition increases the SMA strength recovery during the healing period. The experimental and numerical results concerning capsules breakage are found to be in reasonable agreement. The developed micromechanical model may thus potentially provide a useful tool for optimization of capsules mechanical properties in order to improve their survival during mixture production as well as their timely activation.
Long-Read Sequencing Identifies Novel Pathogenic Intronic Variants in Gitelman Syndrome
Authors: Viering Daan H.H.M. , Hureaux Marguerite , Neveling Kornelia , Latta Femke , Kwint Michael , Blanchard Anne , Konrad Martin , Bindels René J.M. , Schlingmann Karl-Peter , Vargas-Poussou Rosa , de Baaij Jeroen H.F. 
Published: October 2022

Significance Statement
Gitelman syndrome is caused by biallelic pathogenic variants in SLC12A3, which encodes the thiazide-sensitive sodium-chloride cotransporter (NCC). A subset of patients with Gitelman syndrome has only one specific pathogenic variant identified. In this study, long-read sequencing identified 46 previously undetected variants in 95 patients with suspected Gitelman syndrome. A midigene splice assay confirmed the pathogenicity of intronic variants. The data show that both intronic and exonic variants were missed previously and that former detection of one SLC12A3 variant predicts identification of an additional variant. The findings advocate long-read sequencing, complemented with a midigene splice assay, for intronic variants, as a second-tier diagnostic test in patients with one pathogenic SLC12A3 variant.

Background
Gitelman syndrome is a salt-losing tubulopathy characterized by hypokalemic alkalosis and hypomagnesemia. It is caused by homozygous recessive or compound heterozygous pathogenic variants in SLC12A3, which encodes the Na+-Cl− cotransporter (NCC). In up to 10% of patients with Gitelman syndrome, current genetic techniques detect only one specific pathogenic variant. This study aimed to identify a second pathogenic variant in introns, splice sites, or promoters to increase the diagnostic yield.

Methods
Long-read sequencing of SLC12A3 was performed in 67 DNA samples from individuals with suspected Gitelman syndrome in whom a single likely pathogenic or pathogenic variant was previously detected. In addition, we sequenced DNA samples from 28 individuals with one variant of uncertain significance or no candidate variant. Midigene splice assays assessed the pathogenicity of novel intronic variants.

Results
A second likely pathogenic/pathogenic variant was identified in 45 (67%) patients. Those with two likely pathogenic/pathogenic variants had a more severe electrolyte phenotype than other patients. Of the 45 patients, 16 had intronic variants outside of canonic splice sites (nine variants, mostly deep intronic, six novel), whereas 29 patients had an exonic variant or canonic splice site variant. Midigene splice assays of the previously known c.1670-191C>T variant and intronic candidate variants demonstrated aberrant splicing patterns.

Conclusion
Intronic pathogenic variants explain an important part of the missing heritability in Gitelman syndrome. Long-read sequencing should be considered in diagnostic workflows for Gitelman syndrome.
Do Household Financial Behaviors affect Poverty in Indonesia?: Evidence from Indonesian Family Life Survey
Authors: Wardhono Adhitya , Nasir M. Abd. 
Published: October 2022

Poverty is a multidimensional phenomenon that can be measured by variety of approaches. The measurements of poverty based on consumption levels are not sufficient to explain various shortcomings faced by the poor. Household financial behavior that tends to be dynamic will indirectly affect household income patterns. Using data from the Indonesian Family Life Survey (IFLS) wave 5, this study aimed to identify the impact of household financial behavior on poverty in Indonesia. The results of analysis using Tobit Regression showed that the levels of financial vulnerability, financial literacy, education level, arisan or the rotating economy of savings and credit associations (ROSCAs), and total credit have a negative, significant relationship in influencing poverty. This means that when this variable increases, it will reduce poverty in Indonesia. Meanwhile, the location of residence, either in village or city, has a positive, significant relationship which implies that the location of residence has an impact on the poverty level in Indonesia.
Predicting antipsychotic-induced weight gain in first episode psychosis-a protocol for a field-wide systematic review of prognostic factor studies
Authors: Fitzgerald Ita , Crowley Erin K. , Byrne Amy , O’Connell Jean , Ensor Joie , Ní Dhubhlaing Ciara , O'Dwyer Sarah , Sahm Laura J. 
Published: October 2022

<p><strong>Background:</strong> One significant complexity associated with management of antipsychotic-induced weight gain (AIWG) is extensive interindividual variability amongst patients in initial susceptibility to AIWG, time to plateau of weight gain, and resultant final amount of weight gained. Prior to antipsychotic commencement, risk-stratified information highlighting those at increased risk of experiencing significant AIWG would allow tailored weight monitoring and subsequent management protocols to be developed.</p><p><strong>Methods: </strong>This protocol is for a planned systematic review to identify the current utility of baseline clinical, sociodemographic, and biological prognostic factors in predicting the likelihood of significant AIWG occurring prior to antipsychotic commencement. The cohort assessed will be antipsychotic-naïve adults with a first episode of psychosis. Searches for both randomised and prospective non-randomised studies will be undertaken by searching four electronic databases and two trial registers, followed by reference searching, forward citation searching and liaison with content experts. A meta-analysis of study results will be undertaken where study quality and homogeneity allow. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework modified for prognostic research will be used to assess evidence certainty. This protocol was prepared in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Protocols guideline and latest guidance from the Prognosis Methods Group of the Cochrane Collaboration.</p><p><strong>Results: </strong>This review will establish the current quantity, quality and clinical utility of evidence addressing the prognostic association of clinical, biological, and sociodemographic factors in prospectively identifying those more likely to experience significant AIWG.</p><p><strong>Registration details:</strong> PROSPERO registration number CRD42021258148.</p>
Cervical metastasis of undetermined origin: evaluation and criteria for management
Authors: Ayodele Samuel O. , Ologe Foluwasayo E. 
Published: October 2022

<p class="abstract"><strong>Background:</strong> Cervical metastatic cancer of undetermined primary site is described as the presence of metastasis in the cervical lymph node(s) without any identifiable primary site, despite detailed clinical and investigative evaluations. Identification of primary origin is still a big challenge even in the phase of modern diagnostic options. This review was meant to lay open the challenges and offer options of evaluation and managing these cases in a resource limited environment.</p><p class="abstract"><strong>Methods:</strong> The literature search was carried out to retrieve relevant published articles, books, guidelines. The search was limited to articles in English while unpublished literatures were excluded. </p><p class="abstract"><strong>Results:</strong> The process of metastasis might begin before the obvious growth of the primary mass, making detection of primary site of a malignant tumour difficult to determine. There is no current worldwide consensus for evaluation and treatment of cervical metastasis of undetermined primary; however, the primary purpose for management should be towards cure along with locoregional control. This is always based on a well-studied natural history of the mucosal squamous cell cancers of the upper aerodigestive tract.</p><p class="abstract"><strong>Conclusions:</strong> The first step in the work up remains thorough clinical evaluation and the minimum evaluation should include computed tomography scan of the head and neck, core needle biopsy of the metastatic cervical lymph node(s) for histological analysis, panendoscopy and biopsies from suspicious sites in the upper airway. Treatment modalities can be classified into modified radical neck dissection with or without adjuvant radiotherapy, radiotherapy alone, and combination of surgical intervention and chemoradiation.</p>
LARGE SIZED PRODUCT SHELLS DISPLACEMENT MEASUREMENT UNDER STATIC LOADING USING LASER TRACKERS
Authors: Sazonnikova Nadezhda A. , Uklein Roman V. 
Published: October 2022

In the aerospace industry the accuracy of product geometry and the aerodynamic contour provided traditionally, by the mould loft template method. The assembly accuracy control is carried out using optical measuring instruments, such as a level and a theodolit in combination with leveling rulers came to the aircraft industry from geodesy. Measurements are carried out according to reference points pre-embedded in the product at the design stage.
The introduction of modern high precision coordinate measuring machines (CMM) into the production cycle is promising and actively developing direction to improve the quality of manufactured aircraft. To control the geometry of parts and assemblies, stationary portal-type CMMs and mobile CMMs of the "hand" type replace traditional rod tools and templates, and in the assembly and control operations of the product, traditional optical devices are replaced by a laser tracker.
The aim of this paper is the use of laser trackers for non-contact real-time large-sized product shell displacement measurement under static loading, which makes it possible to reduce the complexity and duration of tests, and ensure high measurement accuracy.
Correlation between actual nutrition and lipid peroxidation and antioxidant defense parameters in aged 14–17 years adolescents living in rural area
Authors: Darenskaya M. A. , Rychkova L. V. , Astakhova T. A. , Pogodina A. V. , Dolgikh O. N. , Klimkina Yu. N. , Kolesnikova L. I. 
Published: October 2022

The aim of the study was to reveal the relationship between the parameters of actual nutrition and the lipid peroxidation and antioxidant defense system in adolescents aged 14–17 in a rural area. Material and methods. 76 adolescents aged 14–17 of the Irkutsk region were examined by the cross-sectional study method. Actual nutrition was studied by the 24-hour nutrition reproduction method. The content of substrates with unsaturated double bonds (DB), diene conjugates (DC), ketodienes and conjugated trienes (KD and CT), thiobarbituric acid reacting species (TBARS), α-tocopherol, retinol, reduced (GSH) and oxidized glutathione (GSSG), total blood antioxidant activity (TAA), superoxide dismutase (SOD) activity in blood by spectrophotometry and fluorometry methods were analyzed. Results. The adolescents’ diet did not meet the principles of a balanced diet – there was reduced protein intake, an imbalance of unsaturated fatty acids, A, C, D, B vitamins deficiency. An excessive element in the diet was sodium. The content of substrates with DB, KD and CT and TBARS increased significantly in the studied group of adolescents, the concentration of DC decreased. Parameters of antioxidant defense both decreased (TAA, retinol content) and increased (α-tocopherol, GSH concentration). Correlation analysis showed relationships between DB and vitamin B1, B2 content; DC level and calories, carbohydrate and vitamin B1 content; concentration of KD and CT and fats, TAA and vitamin A and β-carotene level; level of α-tocopherol in blood and vitamin E in food; GSH and vitamin K; SOD activity and vitamin H content. Multiple negative correlations were between GSSG and fat, vitamins B1, B9, C, K food concentration were found.Conclusions. The calculated vitamin consumption indicators allow to reveal nutritional deviations in adolescents and to connect them with the real provision of the body with these metabolites.
Chronotropic action of immobilized subtilisins during the perfusion of an isolated rat heart
Authors: Baikalov G. I. , Leonov N. P. , Madonov P. G. , Ershov K I. , Bakhareva K. I. , Soldatova M. S. 
Published: October 2022

The pharmacological experiments on isolated organs (ex vivo) are the preferred method for assessing the primary pharmacodynamics of the studied drugs, since this method is completely excluded the systemic influence of neurohumoral regulation. In the last decade, a new group of thrombolytic drugs based on immobilized subtilisins has been formed. At the stage of registrational preclinical and clinical studies, their pleiotropic pharmacological effects have not been studied. Meanwhile, there is a reason to consider that their pharmacological activity in the bloodstream is not limited to thrombolytic action, but may be extended to a systemic effect on the cardiovascular system. The aim of the study was to investigate the chronotropic effects of an isolated heart during its perfusion with solutions of immobilized subtilisins at different concentrations. Material and methods. The isolated rat heart model according to Langendorff was used in the study. The experiment included 50 Wistar rats, which were divided into 5 groups: isolated hearts perfused only with Krebs – Henseleit solution (control) or with immobilized subtilisins in 4 concentrations (170, 340, 510 и 1020 U/l). Results and discussion. The immobilized subtilisins have a negative chronotropic effect. The onset of the effect depends on the drug concentration in the solution: the higher concentration, the earlier effect. From 5 to 10 minutes of perfusion, a negative chronotropic effect is observed using of immobilized subtilisins at any dose. The duration of its increase is manifested up to 10–20 minutes, depending on the drug concentration in solution. After 20 minutes of perfusion, the achieved negative chronotropic effect remains at a plateau level up to 40 minutes. Conclusion. The immobilized subtilisins have an independent pharmacological effect on heart rate.
Features of laboratory parameters in children with multisystem inflammatory syndrome associated with SARS-CoV-2
Authors: Obukhova O. O. , Ryabichenko T. I. , Karpovich G. S. , Skosyreva G. A. , Kuimova I. V. , Voevoda M. I. 
Published: October 2022

Multisystem inflammatory syndrome (MIS-C) is a new childhood disease associated with coronavirus SARS-CoV-2 that manifests itself 3–4 weeks after infection. The development of MIS-C is possible, despite the asymptomatic course of coronavirus infection. The pathogenetic features of MIS-C remain unclear. The aim of the study was to investigate the state of peripheral blood parameters in children with multisystem inflammatory syndrome associated with SARS-CoV-2 upon admission to a hospital. Material and methods. We examined 52 children with MIS-C from 1 to 14 years old, hospitalized in Children`s Clinical Hospital No. 3 in Novosibirsk in October–December 2020. Testing for the isolation of SARS-CoV-2 RNA in scrapings from the nasopharynx and oropharynx was carried out using real time PCR (test systems of DNA-Technology, Russia). The presence of specific IgM and IgG antibodies to SARS-CoV-2 in blood serum was determined by ELISA using Vector-Best kits (Russia). Results and discussion. It was noted that SARS-CoV-2 virus RNA was found only in 12.8 % of cases, while specific IgG antibodies in blood serum were detected in 100 % of children. IgM to SARS-CoV-2 antigens were detected in the blood serum only in 53.85 % of children with MIS-C. It has been established that unexpressed leukocytosis was found both in children under the age of 7 and in children of 8–14 years old. However, the leukocytes content in children of the older age group was significantly lower than in children aged 1–7 years. At the same time, in both age groups, some children had extremely low values of the indicator. The causes of severe leukopenia against the background of excessive inflammation remain unclear. Age groups (1–7 and 8–14 years) do not differ statistically significantly in the relative content of lymphocytes and neutrophils. In the study of individual values of the relative content of lymphocytes within the age groups, it was noted that only some children had lymphopenia of varying severity. Conclusions. Against the background of minor leukocytosis in children with MIS-C, upon admission to the hospital, there is a tendency to develop both relative and absolute lymphopenia, regardless of age. The study noted an extremely pronounced variability of individual values of the evaluated peripheral blood parameters, regardless of age, which, with similar clinical symptoms, characterized as MIS-C, requires further study in dynamics, taking into account the initial values of the indicators.There is no pronounced relationship between the leukocytes content and specific IgM antibodies to SARS-CoV-2 antigens in the blood.
Controlling Shareholder Pledges and Cost of Equity Capital: Analyzing Empirical Evidence from A-share Listed Companies
Authors: Guo Cheng , Rong Huang , Yang Zhaiting , Sindakis Stavros , Aggarwal Sakshi 
Published: October 2022

Abstract
With the constant increase in China’s stock pledge transactions, controlling shareholders’ equity pledges may result in inadequate investment, which government regulatory authorities, investors, and financial management departments should be aware of. Taking China’s A-share listed companies from 2013 to 2019 as a sample, this paper examines the impact of controlling shareholder pledge on equity capital cost. It is found that the equity capital cost of listed companies increases significantly after controlling shareholder pledge, and high-quality audit reports help reduce the influence of controlling shareholder pledge on it. In addition, the mechanism test shows that controlling shareholder pledge impacts the equity capital cost by reducing stock liquidity and increasing the tunneling behavior of large shareholders. Further research shows that under controlling shareholder pledges, improving the quality of information disclosure can help reduce the equity capital cost, while stock price risk can increase the equity capital cost.