bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coercion and Dissent: Sleeping Sickness ‘Concentrations’ and the Politics of Colonial Authority in Ulanga, Tanganyika
Authors: Jackson Jonathan M. 
Published: March 2022

AbstractThis article examines the means by which perceived threats of sleeping sickness epidemics were used to justify extensive population resettlement through the formation of ‘concentrations’ in Ulanga District, Tanganyika, between 1939 and 1945. Underlying this specious spatial reordering of communities were ulterior motives that interpreted and pushed broader colonial development agendas of social engineering. The prominent role of leading colonial officers, notably A. T. Culwick, is emphasised and reexamined, especially in relationship to paternalism and the coercive aspects of closer settlement. This article explores the nature of legitimised coercion, contested meanings of the League of Nations mandate, and tensions within the administration. Local resistance to concentration challenged colonial hegemony and the self-fashioned form of benign autocracy constructed by officials like Culwick, who relied on a projection of prestige for political authority in his district and among his peers. Concentration was therefore a contested and contingent process with dissent evidenced both against and within government.
Impact of coronavirus disease 2019 on head and neck urgent suspected cancer referral pathways in rural Wales
Authors: Abelardo E , Gravelle R , Scannell M , Shastri P , Vandekar M , Davies G , Volpini L , Prabhu V 
Published: March 2022

AbstractObjectiveTo assess the impact of the coronavirus disease 2019 pandemic on head and neck urgent suspected cancer referral pathways in rural areas of Wales.MethodA retrospective audit was conducted of 2234 head and neck urgent suspected cancer referrals received from January 2019 to November 2020.ResultsThe referrals dropped by 35 per cent in 2020 compared to the same period in 2019. The time from general practitioner referral to the first ENT appointment improved during the pandemic (8.0 vs 10.0 days; p < 0.001). Of referrals, 92.1 per cent were seen within a 14-day period in 2020, compared with 79.6 per cent in 2019 (p < 0.001). There were no differences between 2020 and 2019 in terms of: the (confirmed cancer) conversion rate (10.6 per cent vs 9.7 per cent; p = 0.60), general practitioner referral to multidisciplinary team discussion time (35.5 vs 41.5 days; p = 0.40) or general practitioner referral to initiation of treatment time (68.0 vs 78.0 days; p = 0.16).ConclusionWhilst coronavirus disease 2019 reduced the number of overall head and neck urgent suspected cancer referrals, the pathways were generally unchanged, if not slightly improved, in rural Wales.
Indeterminacy in L1 French grammars: the case of gender and number agreement
Authors: Ayoun Dalila 
Published: March 2022

AbstractAlthough L1 French speakers (FS) acquire the formal features of gender and number early, agreement appears to take longer, leading to persistent difficulties even for cases of straightforward agreement within a nominal or verbal phrase. This begs the questions of how adult FSs (n = 168) may fare with idiosyncratic cases of agreement such as nominal affective constructions and past participles as measured by a written grammaticality judgment /correction task and preference/grammaticality judgment task. The findings showing that participants performed better at correctly accepting than rejecting stimuli, are consistent with an increasing number of empirical studies revealing individual differences among adult L1 speakers. The findings are discussed from a generative perspective and the usage-based perspective of the Basic Language Cognition-High Language Cognition theory of L1 proficiency (Hulstijn, 2015).
Do diets with higher carbon footprints increase the risk of mortality? A population-based simulation study using self-selected diets from the USA
Authors: Pollock Benjamin D , Willits-Smith Amelia M , Heller Martin C , Bazzano Lydia A , Rose Donald 
Published: March 2022

AbstractObjective:Are diets with a greater environmental impact less healthy? This is a key question for nutrition policy, but previous research does not provide a clear answer. To address this, our objective here was to test whether American diets with the highest carbon footprints predicted greater population-level mortality from diet-related chronic disease than those with the lowest.Design:Baseline dietary recall data were combined with a database of greenhouse gases emitted in the production of foods to estimate a carbon footprint for each diet. Diets were ranked on their carbon footprints and those in the highest and lowest quintiles were studied here. Preventable Risk Integrated Model (PRIME), an epidemiological modelling software, was used to assess CVD and cancer mortality for a simulated dietary change from the highest to the lowest impact diets. The diet–mortality relationships used by PRIME came from published meta-analyses of randomised controlled trials and prospective cohort studies.Setting:USA.Participants:Baseline diets came from adults (n 12 865) in the nationally representative 2005–2010 National Health and Nutrition Examination Survey.Results:A simulated change at the population level from the highest to the lowest carbon footprint diets resulted in 23 739 (95 % CI 20 349, 27 065) fewer annual deaths from CVD and cancer. This represents a 1·83 % (95 % CI 1·57 %, 2·08 %) decrease in total deaths. About 95 % of deaths averted were from CVD.Conclusions:Diets with the highest carbon footprints were associated with a greater risk of mortality than the lowest, suggesting that dietary guidance could incorporate sustainability information to reinforce health messaging.
Cost and Capability Compromises in STEM Instrumentation for Low-Voltage Imaging
Authors: Quigley Frances , McBean Patrick , O'Donovan Peter , Peters Jonathan J P , Jones Lewys 
Published: March 2022

Abstract
Low-voltage transmission electron microscopy (≤80 kV) has many applications in imaging beam-sensitive samples, such as metallic nanoparticles, which may become damaged at higher voltages. To improve resolution, spherical aberration can be corrected for in a scanning transmission electron microscope (STEM); however, chromatic aberration may then dominate, limiting the ultimate resolution of the microscope. Using image simulations, we examine how a chromatic aberration corrector, different objective lenses, and different beam energy spreads each affect the image quality of a gold nanoparticle imaged at low voltages in a spherical aberration-corrected STEM. A quantitative analysis of the simulated examples can inform the choice of instrumentation for low-voltage imaging. We here demonstrate a methodology whereby the optimum energy spread to operate a specific STEM can be deduced. This methodology can then be adapted to the specific sample and instrument of the reader, enabling them to make an informed economical choice as to what would be most beneficial for their STEM in the cost-conscious landscape of scientific infrastructure.
Withdrawn: Similar Isotopic Biases of Plant Stem Bulk Water From Different Water Sources by Cryogenic Vacuum Distillation Demonstrated Through Rehydration Experiments
Authors: Zhao Pei , Sprenger Matthias , Barzegar Rahim , Tang Xiangyu , Adamowski Jan 
Published: March 2022

AbstractZhao, P., Sprenger, M., Barzegar, R., Tang, X., & Adamowski, J. (2022). Similar isotopic biases of plant stem bulk water from different water sources by cryogenic vacuum distillation demonstrated through rehydration experiments. Geophysical Research Letters, 49, e2021GL096474. The above article from Geophysical Research Letters, published online on 30 March 2022 in Wiley Online Library (http://wileyonlinelibrary.com), has been withdrawn by agreement among the authors, the Editor‐in‐Chief Harihar Rajaram, the American Geophysical Union, and Wiley Periodicals, LLC. The withdrawal has been agreed because the authors discovered, after acceptance of the article but before final publication, some accidental transcription/typo errors in the data (for some δ2H and δ18O values) which would affect some of the results and cannot be sufficiently corrected to the authors' satisfaction.
Numerical Simulations on Day‐to‐Day Variations of Low‐Latitude Es Layers at Arecibo
Authors: Andoh Satoshi , Saito Akinori , Shinagawa Hiroyuki 
Published: March 2022

AbstractTo reveal mechanisms of day‐to‐day variations of the low‐latitude sporadic E (Es) layers, Es layer simulations were performed and compared to plasma layers observed by the Arecibo radar. Many studies have been conducted about the Es layers till now. However, few studies investigated the day‐to‐day variations of the Es layers especially at the low‐latitudes. Herein, for the first time, our numerical model generally succeeded in reproducing features of the day‐to‐day variations of the low‐latitude Es layers. We found that the day‐to‐day variations of the Es layers are created by a combination of day‐to‐day variations of zonal/meridional‐wind shears driven by the tides and the downward phase velocity of the tides. The wind‐driven mechanism generally explains the day‐to‐day variations of the low‐latitude Es layers.
The Formation of Terraces on Asteroid (101955) Bennu
Authors: Barnouin O. S. , Daly M. G. , Seabrook J. A. , Zhang Y. , Thuillet F. , Michel P. , Roberts J. H. , Daly R. T. , Perry M. E. , Susorney H. C. M. , Jawin E. R. , Ballouz R.‐L. , Walsh K. J. , Sevalia M. M. , Al Asad M. M. , Johnson C. L. , Bierhaus E. B. , Gaskell R. W. , Palmer E. E. , Weirich J. , Rizk B. , Drouet D’Aubigny C. Y. , Nolan M. C. , DellaGiustina D. N. , Scheeres D. J. , McMahon J. W. , Connolly H. C. , Richardson D. C. , Wolner C. W. V. , Lauretta D. S. 
Published: March 2022

AbstractThe surface of the rubble‐pile asteroid (101955) Bennu has been characterized in detail by the OSIRIS‐REx (Origins, Spectral Interpretation, Resource Identification, and Security–Regolith Explorer) mission. By examining global and local digital terrain models, we observed that Bennu possesses terraces, that is, a series of roughly latitude‐parallel, step‐like slope breaks. These partially circumscribe the poles and extend east‐west over several longitudinal quadrants at mid‐ to high (≥30°) latitudes. The terraces are subtle in amplitude, with heights ranging from 1 to 5 m. They often exhibit back‐wasting that results in V‐shaped scarps that open downslope in some locations. When boulders >5–10 m are absent at or near a terrace, the steeper portion (the drop) of the terrace lacks rocks, whereas the flatter portion (the bench) of the terrace has accumulations of rocks at its crest. When boulders >5–10 m are present, their steep downslope faces often make up the drop from the terrace crest, and they retain debris upslope, thereby enhancing the terrace structure. A geotechnical stability analysis indicates that Bennu's surface is likely unstable and that surface cohesion is <0.6 Pa. Bennu's terraces strongly resemble scarps generated in laboratory and numerical simulations of a cohesionless granular bed as the slope of the bed increases quasi‐statically. We conclude that terraces are probably actively forming on Bennu as its surface slowly fails owing to creep induced by spin acceleration.
Hydro‐Mechanical Interactions of a Rock Slope With a Retreating Temperate Valley Glacier
Authors: Hugentobler Marc , Aaron Jordan , Loew Simon , Roques Clément 
Published: March 2022

AbstractRock slope failures often result from progressive rock mass damage which accumulates over long timescales. In deglaciating environments, rock slopes are affected by stress perturbations driven by mechanical unloading due to ice downwasting and concurrent changes in thermal and hydraulic boundary conditions. Since in‐situ data are rare, the different processes and their relative contribution to slope damage remain poorly understood. Here, we analyze borehole monitoring data from a rock slope adjacent to the retreating Great Aletsch Glacier (Switzerland) and compare it to englacial water levels, climate data, and decreasing ice levels. Rock slope pore pressures show a seasonal signal controlled by infiltration events as well as effects from the connectivity to the englacial hydrological system. We find that reversible and irreversible strains are driven by: (a) hydromechanical effects caused by englacial pressure fluctuations and infiltration events, (b) stress transfer related to changing mechanical glacial loads from short‐term englacial water level fluctuations and longer term ice downwasting, and (c) thermomechanical effects from annual temperature cycles penetrating the shallow subsurface, which primarily result in reversible deformation. We relate most observed irreversible strain (damage) to mechanical unloading from ice downwasting. Damage is strongest directly at the ice margin and moves through the slope at the pace of glacial retreat and advance. Locations with many retreat/advance cycles are very sensitive to landslide formation. The current climate warming impacts very sensitive valley sectors, which is confirmed by landslide distributions and activity in the study area.
Space Weathering of the Chang'e‐5 Lunar Sample From a Mid‐High Latitude Region on the Moon
Authors: Gu Lixin , Chen Yongjin , Xu Yuchen , Tang Xu , Lin Yangting , Noguchi Takaaki , Li Jinhua 
Published: March 2022

AbstractMicrometeorite impacts and solar wind irradiation, the dominant space weathering (SW) processes, largely modified compositions and microtexture of soil materials on the Moon. Here, we report the SW characteristics of the Chang'e‐5 lunar soils from mid‐high latitude (43.06°N). All mineral phases exposed on the surface of a single basalt clast have a vapor deposit layer, whereas the textures of the solar wind irradiation‐damaged zone are dependent on the host mineral species. Nanophase Fe (npFe0) particles are spherical in the amorphized zone of pyroxenes, elongated in ilmenite, and irregular on the jagged surface of iron sulfide, but not found in Fe‐poor merrillite. Vesicles were found in the damaged zone of ilmenite and merrillite, but with different shapes. The observations were compared to Apollo samples and demonstrate no significant altitude‐dependent effects on the SW, which is important for decoding the reflectance spectra of the Moon.
The blood-brain barrier in aging and neurodegeneration
Authors: Knox Emily G. , Aburto Maria R. , Clarke Gerard , Cryan John F. , O’Driscoll Caitriona M. 
Published: March 2022

AbstractThe blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma. Moreover, the BBB prevents unwanted toxins and pathogens from entering the brain. This barrier, however, breaks down with age and further disruption is a hallmark of many age-related disorders. Several drugs have been explored, thus far, to protect or restore BBB function. With the recent connection between the BBB and gut microbiota, microbial-derived metabolites have been explored for their capabilities to protect and restore BBB physiology. This review, will focus on the vital components that make up the BBB, dissect levels of disruption of the barrier, and discuss current drugs and therapeutics that maintain barrier integrity and the recent discoveries of effects microbial-derived metabolites have on BBB physiology.
Developing symptom clusters: linking inflammatory biomarkers to depressive symptom profiles
Authors: Franklyn Sabina I. , Stewart Jayme , Beaurepaire Cecile , Thaw Emily , McQuaid Robyn J. 
Published: March 2022

AbstractConsidering the burden of depression and the lack of efficacy of available treatments, there is a need for biomarkers to predict tailored or personalized treatments. However, identifying reliable biomarkers for depression has been challenging, likely owing to the vast symptom heterogeneity and high rates of comorbidity that exists. Examining biomarkers that map onto dimensions of depression as well as shared symptoms/constructs that cut across disorders could be most effective for informing personalized treatment approaches. With a sample of 539 young adults, we conducted a principal component analysis (PCA) followed by hierarchical cluster analysis to develop transdiagnostic clusters of depression and anxiety symptoms. We collected blood to assess whether neuroendocrine (cortisol) and inflammatory profiles (C-reactive protein (CRP), Interleukin (IL)-6, and tumor necrosis factor (TNF) – α) could be used to differentiate symptom clusters. Six distinct clusters were identified that differed significantly on symptom dimensions including somatic anxiety, general anxiety, anhedonia, and neurovegetative depression. Moreover, the neurovegetative depression cluster displayed significantly elevated CRP levels compared to other clusters. In fact, inflammation was not strongly associated with overall depression scores or severity, but rather related to specific features of depression marked by eating, appetite, and tiredness. This study emphasizes the importance of characterizing the biological underpinnings of symptom dimensions and subtypes to better understand the etiology of complex mental health disorders such as depression.
DNA methylation signatures in human neonatal blood following maternal antenatal corticosteroid treatment
Authors: Kim Bona , Sasaki Aya , Murphy Kellie , Matthews Stephen G. 
Published: March 2022

AbstractAntenatal corticosteroids (ACS) are used to treat women at risk of preterm birth to improve neonatal survival. Though affected children may be at long-term risk of neurobehavioural disorders, the driving mechanisms remain unknown. Animal studies have shown that ACS exposure can lead to overlapping changes in DNA methylation between the blood and the brain, identifying gene pathways for neurodevelopment, which highlights the potential to examine peripheral blood as a surrogate for inaccessible human brain tissue. We hypothesized that differential methylation will be identified in blood of term-born neonates following ACS. Mother-infant dyads that received ACS were retrospectively identified through the Ontario Birth Study at Sinai Health Complex and matched to untreated controls for maternal age, BMI, parity and foetal sex (n = 14/group). Genome-wide methylation differences were examined at single-nucleotide resolution in DNA extracted from dried bloodspot cards using reduced representative bisulfite sequencing approaches. 505 differentially methylated CpG sites (DMCs) were identified, wherein 231 were hypermethylated and 274 were hypomethylated. These sites were annotated to 219 genes, of which USP48, SH3PXD2A, NTM, CAMK2N2, MAP6D1 were five of the top ten genes with known neurological function. Collectively, the set of hypermethylated genes were enriched for pathways of transcription regulation, while pathways of proteasome activity were enriched among the set of hypomethylated genes. This study is the first to identify DNA methylation changes in human neonatal blood following ACS. Understanding the epigenetic changes that occur in response to ACS will support future investigations to delineate the effects of prenatal glucocorticoid exposure on human development.
Cell cycle regulation: p53-p21-RB signaling
Authors: Engeland Kurt 
Published: March 2022

AbstractThe retinoblastoma protein RB and the transcription factor p53 are central tumor suppressors. They are often found inactivated in various tumor types. Both proteins play central roles in regulating the cell division cycle. RB forms complexes with the E2F family of transcription factors and downregulates numerous genes. Among the RB-E2F target genes, a large number code for key cell cycle regulators. Their transcriptional repression by the RB-E2F complex is released through phosphorylation of RB, leading to expression of the cell cycle regulators. The release from repression can be prevented by the cyclin-dependent kinase inhibitor p21/CDKN1A. The CDKN1A gene is transcriptionally activated by p53. Taken together, these elements constitute the p53-p21-RB signaling pathway. Following activation of p53, for example by viral infection or induction of DNA damage, p21 expression is upregulated. High levels of p21 then result in RB-E2F complex formation and downregulation of a large number of cell cycle genes. Thus, p53-dependent transcriptional repression is indirect. The reduced expression of the many regulators leads to cell cycle arrest. Examination of the p53-p21-RB targets and genes controlled by the related p53-p21-DREAM signaling pathway reveals that there is a large overlap of the two groups. Mechanistically this can be explained by replacing RB-E2F complexes with the DREAM transcriptional repressor complex at E2F sites in target promoters. In contrast to RB-E2F, DREAM can downregulate genes also through CHR transcription factor binding sites. This results in a distinct gene set controlled by p53-p21-DREAM signaling independent of RB-E2F. Furthermore, RB has non-canonical functions without binding to E2F and DNA. Such a role of RB supporting DREAM formation may be exerted by the RB-SKP2-p27-cyclin A/E-CDK2-p130-DREAM link. In the current synopsis, the mechanism of regulation by p53-p21-RB signaling is assessed and the overlap with p53-p21-DREAM signaling is examined.
Hyper-CEST NMR of metal organic polyhedral cages reveals hidden diastereomers with diverse guest exchange kinetics
Authors: Jayapaul Jabadurai , Komulainen Sanna , Zhivonitko Vladimir V. , Mareš Jiří , Giri Chandan , Rissanen Kari , Lantto Perttu , Telkki Ville-Veikko , Schröder Leif 
Published: March 2022

AbstractGuest capture and release are important properties of self-assembling nanostructures. Over time, a significant fraction of guests might engage in short-lived states with different symmetry and stereoselectivity and transit frequently between multiple environments, thereby escaping common spectroscopy techniques. Here, we investigate the cavity of an iron-based metal organic polyhedron (Fe-MOP) using spin-hyperpolarized 129Xe Chemical Exchange Saturation Transfer (hyper-CEST) NMR. We report strong signals unknown from previous studies that persist under different perturbations. On-the-fly delivery of hyperpolarized gas yields CEST signatures that reflect different Xe exchange kinetics from multiple environments. Dilute pools with ~ 104-fold lower spin numbers than reported for directly detected hyperpolarized nuclei are readily detected due to efficient guest turnover. The system is further probed by instantaneous and medium timescale perturbations. Computational modeling indicates that these signals originate likely from Xe bound to three Fe-MOP diastereomers (T, C3, S4). The symmetry thus induces steric effects with aperture size changes that tunes selective spin manipulation as it is employed in CEST MRI agents and, potentially, impacts other processes occurring on the millisecond time scale.