bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dosages of swallowing exercises in stroke rehabilitation: a systematic review
Authors: Choy Jacinda , Pourkazemi Fereshteh , Anderson Caitlin , Bogaardt Hans 
Published: December 2022

Abstract
Purpose
To investigate the dosages of swallowing exercises reported in intervention studies on post-stroke dysphagia through systematic review.

Methods
Five electronic databases were searched from inception until February 2022 with reference tracing of included studies. Studies were included, where adults with post-stroke dysphagia received rehabilitative, behavioural swallowing exercises, pre/post outcomes were reported, and intervention dosage was described in detail, including frequency, intensity, time, and type of exercise. Two reviewers independently screened studies and rated quality using ASHA Levels of Evidence tool. Data was tabulated and narratively described.

Results
54 studies were included with a total 1501 participants. Studies included 28 randomised controlled trials, 8 non-randomised controlled trials, 12 pre/post studies, 3 retrospective case controls and 3 case studies. Results showed inconsistent reporting of intervention dosage, with intensity the least consistently reported dosage component. While swallowing intervention was most commonly provided five times per week for four weeks, there was a wide breadth of type, frequency, intensity and duration of swallowing exercises reported. Dosage under-reporting and variation was particularly observed in “standard care” co-interventions or control groups. Study strengths included following PRISMA guidelines, providing a comprehensive review of swallowing exercise methodology and dosages, and including non-English studies. The limitation was lack of meta-analysis due to the heterogeneity of included studies.

Conclusions
Dosages of swallowing exercises are inconsistently reported and vary significantly in post-stroke dysphagia studies. Results indicate the need for consistent and comprehensive dosage reporting in dysphagia studies, and for further research into evidence-based principles to optimise swallowing exercise dosages.

Systematic review registration number
131294
A novel homozygous p.Ser69Pro SOD1 mutation causes severe young-onset ALS with decreased enzyme activity
Authors: Fahmy Nagia , Müller Kathrin , Andersen Peter Munch , Marklund Stefan L. , Otto Markus , Ludolph Albert C. , Hamdi Nabila 
Published: December 2022

Abstract
Background
The dose–effect of various SOD1 mutations on SOD1 enzymatic activity offers valuable insights into ALS pathogenesis with possible therapeutic implications. Homozygous SOD1 mutations, yet scarce, are of special interest. We report a novel homozygous SOD1 mutation with decreased enzymatic activity and severe early onset ALS phenotype.

Methods
Whole exome sequencing and targeted screening of commonly implicated genes were conducted. Repeat-primed PCR and fragment length analysis were used for C9orf72. Bi-directional Sanger sequencing was used for SOD1 and other genes. SOD1 activity was measured by direct spectrophotometry. Serum neurofilament light chain level was measured by the ELLA immunoassay system.

Results
The homozygous patient for a novel SOD1 variant p.Ser69Pro showed poor SOD1 enzymatic activity (16% of controls) and an early onset ALS phenotype predominantly affecting lower motor neurons with rapid involvement of the trunk, upper limbs and bulbar muscles. The asymptomatic heterozygous relatives had at least 68% of normal enzyme activity. Level of serum neurofilament light chain was much higher (148 pg/ml) in the patient than the relatives who had normal levels (6–10 pg/ml).

Conclusion
This novel mutation adds knowledge to the ALS genotype–phenotype spectrum and supports the strong dose–effect of SOD1 mutations associated with severely decreased enzymatic activity.
Aerococcus urinae — significance of detection in the paediatric urinary tract: a case series
Authors: Rast Dimitri , Evers Katrina Suzanne , Egli Adrian , Rudin Christoph , Goischke Alexandra , Ritz Nicole 
Published: December 2022

Abstract
Aerococcus urinae (A. urinae) is primarily recognized as a common pathogen in the geriatric population, causing urinary tract infection (UTI), sepsis, and endocarditis, predominantly in female patients. In the paediatric population, only a few case reports exist suggesting A. urinae causes malodorous urine in otherwise healthy boys. In this study, we investigated the spectrum of clinical and laboratory presentations of A. urinae detection in children. A retrospective, single-centre, case series including all patients with the detection of A. urinae during a 7-year study period. Patients with detection of A. urinae only in non-urogenital skin swabs were excluded. A total of 40 samples from 33 patients were identified of which 20 patients were included in the final analysis. The median (IQR) age was 6.8 (2.9–9.5) years; 18 (90%) patients were boys. Four patients were diagnosed with a UTI, six had malodorous urine without UTI, three were diagnosed with balanitis and seven showed A. urinae colonization in the urine culture. Urogenital disorders were present in 12 patients. Additional pathogens were detected in 13 patients. Recurrence of detection during our study period was observed in four (20%) patients. Conclusion: Beyond malodorous urine, A. urinae detection is associated with more severe presentations including UTI in the paediatric population. Pre-existing urogenital disorders were frequent, and therefore, a nephro-urological investigation should be considered in all cases of A. urinae detection in the paediatric population.

What is Known:• Aerococcus urinae (A. urinae) is known to be a common pathogen in the geriatric population, causing urinary tract infection (UTI), sepsis, and endocarditis, predominantly in female patients.• In the paediatric population, A. urinae is mainly described as a low-grade pathogen. Some case reports describe A. urinae as the cause of extraordinary malodorous urine in otherwise healthy boys.

What is New:• Beyond malodorous urine, A. urinae detection is associated with more severe presentations including UTI in the paediatric population.• A. urinae was mainly detected in boys with pre-existing urogenital disorders; therefore, a nephro-urological investigation should be considered in cases of A. urinae detection in the paediatric population.
A surrogate model for the prediction of permeabilities and flow through porous media: a machine learning approach based on stochastic Brownian motion
Authors: Niekamp Rainer , Niemann Johanna , Schröder Jörg 
Published: December 2022

AbstractIn this contribution we propose a data-driven surrogate model for the prediction of permeabilities and laminar flow through two-dimensional random micro-heterogeneous materials; here Darcy’s law is used. The philosophy of the proposed scheme is to provide a large number of training sets through a numerically “cheap” (stochastic) model instead of using an “expensive” (FEM) one. In order to achieve an efficient computational tool for the generation of the database (up to $$10^3$$

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and much more realizations), needed for the training of the neural networks, we apply a stochastic model based on the Brownian motion. An efficient algebraic algorithm compared to a classical Monte Carlo approach is based on the evaluation of stochastic transition matrices. For the encoding of the microstructure and the optimization of the surrogate model, we compare two architectures, the so-called UResNet model and the Fourier Convolutional Neural Network (FCNN). Here we analyze two FCNNs, one based on the discrete cosine transformation and one based on the complex-valued discrete Fourier transformation. Finally, we compare the flux fields and the permeabilities for independent microstructures (not used in the training set) with results from the $$\hbox {FE}^2$$

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method, a numerical homogenization scheme, in order to demonstrate the efficiency of the proposed surrogate model.
Linear parallel algorithms to compute strong and branching bisimilarity
Authors: Martens Jan , Groote Jan Friso , Haak Lars B. van den , Hijma Pieter , Wijs Anton 
Published: December 2022

AbstractWe present the first parallel algorithms that decide strong and branching bisimilarity in linear time. More precisely, if a transition system has n states, m transitions and $$\vert Act \vert $$

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action labels, we introduce an algorithm that decides strong bisimilarity in $$\mathcal {O}(n+\vert Act \vert )$$

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time on $$\max (n,m)$$

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processors and an algorithm that decides branching bisimilarity in $$\mathcal {O}(n+\vert Act \vert )$$

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time using up to $$\max (n^2,m,\vert Act \vert n)$$

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processors.
Effect of Modifiers on the Microstructure of Rapidly Solidified AlSi10Mg Alloy
Authors: Marola Silvia , Fiore Gianluca , Battezzati Livio 
Published: December 2022

Abstract
In this work, melt-spun ribbons of AlSi10Mg added with modifiers (Er, Sr, or nano-TiB2) were produced to investigate the combined effect of modification and rapid solidification on eutectic Si. The resulting eutectic microstructures are more isotropic in comparison to that of the base alloy affecting the mechanical properties of the alloys. The modification of Si morphology and supersaturation caused by the modifiers were investigated by microscopy, X-ray diffraction, and differential scanning calorimetry. Compared to melt-spun AlSi10Mg, the eutectic Si network is finer and less continuous when Er or Sr is added, and disrupted with rounded crystals dispersed in the matrix when adding nano-TiB2. The level of supersaturation decreases in the order Er–nano-TiB2–Sr. A transition from columnar Al grains at the wheel side to finer equiaxed grains at the air side was found in the unmodified ribbon and in the one containing nano-TiB2 by means of electron backscattered diffraction. The Er- and Sr-modified ribbons display equiaxed Al grains of constant size throughout their thickness. The average hardness obtained by nano-indentation tests was lower than that of AlSi10Mg. The less continuous Si network causes the hardness drop but provides more isotropic mechanical properties.
Robotic training for medical students: feasibility of a pilot simulation curriculum
Authors: Greenberg Anya L. , Syed Shareef M. , Alseidi Adnan , O’Sullivan Patricia S. , Chern Hueylan 
Published: December 2022

AbstractWhile robotic procedures are growing rapidly, medical students have a limited role in robotic surgeries. Curricula are needed to enhance engagement. We examined feasibility of augmenting Intuitive Surgical (IS) robotic training for medical students. As a pilot, 18 senior students accepted an invitation to a simulation course with a daVinci robot trainer. Course teaching objectives included introducing robotic features, functionalities, and roles. A 1-h online module from the IS learning platform and a 4-h in-person session comprised the course. The in-person session included an overview of the robot by an IS trainer (1.5 h), skills practice at console (1.5 h), and a simulation exercise focused on the bedside assist role (1 h). Feasibility included assessing implementation and acceptability using a post-session survey and focus group (FG). Survey responses were compiled. FG transcripts were analyzed using inductive thematic analysis techniques. Fourteen students participated. Implementation was successful as interested students signed up and completed each of the course components. Regarding acceptability, students reported the training valuable and recommended it as preparation for robotic cases during core clerkships and sub-internships. In addition, FGs revealed 4 themes: (1) perceived expectations of students in the OR; (2) OR vs. outside-OR learning; (3) simulation of stress; and (4) opportunities to improve the simulation component. To increase preparation for the robotic OR and shift robotic training earlier in the surgical education continuum, educators should consider hands-on simulation for medical students. We demonstrate feasibility although logistics may limit scalability for large numbers of students.
Ileal Pouch-Anal Anastomosis in the Older Adult: a Review of Postoperative Outcomes and Pouchitis Treatment
Authors: Chen Sabrina L. , Faye Adam S. , Chang Shannon 
Published: December 2022

AbstractPurpose of ReviewIleal pouch-anal anastomosis (IPAA) has become the preferred surgical treatment for patients with medically refractive ulcerative colitis (UC). Previous studies have suggested that outcomes of this procedure may be worse in older patients; however, more recent reports have suggested that IPAA in select patients is safe, feasible, and results in good quality of life. In this review, we discuss the recent literature surrounding clinical considerations and treatment management of IPAA in older adults.Recent FindingsIPAA complication rates and adverse events are similar in the older adult population, as compared to the younger adult patient population. Although fecal urgency and incontinence may be more common among older adults, chronological age alone is not a contraindication for IPAA surgery, as good quality of life can still be achieved. In this review, we will also discuss the development of pouchitis after IPAA, particularly among older adults, as the emergence of newer biologic drugs has shifted the treatment landscape.SummaryIPAA can be a safe and effective treatment modality for older adults with UC, with high self-reported patient satisfaction. Patient optimization and careful case selection are vital to achieving these outcomes, and specialized preoperative assessments and counseling can help facilitate the proper treatment.
Kultur, Soziale Arbeit und Kulturelle Bildung
Authors: Thole Werner , Hübner Kerstin 
Published: December 2022

ZusammenfassungDer Beitrag erörtert nach historischen Vergewisserungen die Wechselbeziehungen und die Zusammenarbeit zwischen kulturellen und sozialen Gesellschaftsbereichen, der Kulturellen Bildung und der Sozialen Arbeit. Angesichts gesellschaftlicher Veränderungen wird davon ausgegangen, dass eine konturenscharfe Trennung zwischen dem Kulturellen und dem Sozialen nicht mehr durchgängig möglich ist.
125I brachytherapy: a useful treatment to control painful osteoblastic bone metastases
Authors: Liu Yiming , Zhang Chengzhi , Xu Kaihao , Wu Kunpeng , Han Xinwei , Jiao Dechao 
Published: December 2022

Abstract
Backgrounds
125I brachytherapy is effective in relieving cancer pain due to osteolytic bone metastases. However, fewer studies focused on painful osteoblastic bone metastases (OBMs), we conducted a retrospective study to evaluate the efficacy of 125I brachytherapy for the treatment of painful OBMs.

Methods
From April 2017 to April 2019, clinical data of a total of 65 patients with OBMs who underwent CT/cone beam CT -guided 125I brachytherapy were collected and analyzed. The primary study endpoints were technical success, relief of pain (RoP), and quality of life (QoL). The secondary study endpoints were treatment-related complications, local tumor control (LCR), and overall survival (OS). The logistic regression analysis was performed to predict RoP.

Results
Technical success rate was 100%. Visual analog scale scores and daily morphine consumption continuously decreased significantly at 2 weeks, 6 weeks, and 10 weeks (all P < 0.05). The RoP at 6 weeks was 84.62%. QoL presented improvement at 6 and 10 weeks. Only minor complications occurred in 12 patients (18.46%). LCR was 93.85% at 10 weeks. The OS was 29.80 months. Two factors were significantly associated with the RoP: max diameter (MD, < 3 cm vs. ≥ 3 cm, P = 0.019) and serum levels of bone alkaline phosphatase (B-ALP, ≥ 100 U/L vs. < 100 U/L, P = 0.016).

Conclusions
125I brachytherapy is an effective treatment in relieving painful OBMs and improving patients’ QoL.
Second Allogeneic Hematopoietic Stem Cell Transplantation for Hemophagocytic Syndrome with Engraftment Failure
Authors: Jiang Fan , Liu Zhouyang , Guo Zikuan , Xiao Juan , Wu Nanhai , Fan Shifen , Yue Yan , Chen Jiao , Sun Yuan 
Published: December 2022

AbstractThis study aims to assess the efficacy of second allogeneic hemopoietic stem cell transplantation (allo-HSCT) for treating hemophagocytic syndrome with first engraftment failure. Among a total of 35 patients who underwent allo-HSCT between June 2015 and July 2021 for HLH, 10 patients who underwent a second HSCT following graft rejection were retrospectively analyzed. Various factors, such as the treatment course and outcome, the remission status, donor selection, and the conditioning regimen of patients before second allo-HSCT, were scrutinized for transplant-related complications and transplant-related mortality, as well as transplant outcomes. All the subjects have achieved complete donor engraftment, in which the neutrophils and platelets engraftment occurred in a median time of 12 d (range 10–19 d) and 24 d (range 11–97 d), respectively. Among the selected subjects, 20% of patients are diseased due to transplant-related thrombotic microangiopathy. Further, 90% of patients are diagnosed with aGVHD, in which 3 of them with grade I aGVHD, one patient with grade II aGVHD, two patients with grade III GVHD, and three patients with localized chronic GVHD. Moreover, 70% of patients showed signs of combined viral infections. Despite the complex symptoms, the overall survival rate is around 80%, with transplant-related mortality and the incidence of post-transplant GVHD of 20% and 60%, respectively. Together, our findings indicated that the second allo-HSCT showed great potential in treating hemophagocytic syndrome with engraftment failure.
Mannose-modified hyaluronic acid nanocapsules for the targeting of tumor-associated macrophages
Authors: Fernández-Mariño Iago , Anfray Clément , Crecente-Campo Jose , Maeda Akihiro , Ummarino Aldo , Teijeiro-Valiño Carmen , Blanco-Martinez Dario , Mpambani Francis , Poul Laurence , Devalliere Julie , Germain Matthieu , Correa Juan , Fernandez-Villamarin Marcos , Allavena Paola , Fernandez-Megia Eduardo , Alonso María José , Andón Fernando Torres 
Published: December 2022

Abstract
Tumor-associated macrophages (TAMs), a class of immune cells that play a key role in tumor immunosuppression, are recognized as important targets to improve cancer prognosis and treatment. Consequently, the engineering of drug delivery nanocarriers that can reach TAMs has acquired special relevance. This work describes the development and biological evaluation of a panel of hyaluronic acid (HA) nanocapsules (NCs), with different compositions and prepared by different techniques, designed to target macrophages. The results showed that plain HA NCs did not significantly influence the polarization of M0 and M2-like macrophages towards an M1-like pro-inflammatory phenotype; however, the chemical functionalization of HA with mannose (HA-Man) led to a significant increase of NCs uptake by M2 macrophages in vitro and to an improved biodistribution in a MN/MNCA1 fibrosarcoma mouse model with high infiltration of TAMs. These functionalized HA-Man NCs showed a higher accumulation in the tumor compared to non-modified HA NCs. Finally, the pre-administration of the liposomal liver occupying agent Nanoprimer™ further increased the accumulation of the HA-Man NCs in the tumor. This work highlights the promise shown by the HA-Man NCs to target TAMs and thus provides new options for the development of nanomedicine and immunotherapy-based cancer treatments.
Graphical abstract
Design, synthesis, and biological investigation of quinoline/ciprofloxacin hybrids as antimicrobial and anti-proliferative agents
Authors: Ezelarab Hend A. A. , Hassan Heba A. , Abuo-Rahma Gamal El-Din A. , Abbas Samar H. 
Published: December 2022

AbstractCiprofloxacin-Piperazine C-7 linked quinoline derivatives 6a–c and 8a–c were synthesized and investigated for their antibacterial, antifungal, and anti-proliferative activities. Ciprofloxacin-quinoline-4-yl-1,3,4 oxadiazoles 6a and 6b showed promising anticancer activity against SR- leukemia and UO-31 renal cancer cell lines. The hybrids 8a–c and compound 6b exhibited noticeable antifungal activities against C.Albicans; 8a experienced the most potent antifungal activity compared to Itraconazole with MICs of 21.88 µg/mL and 11.22 µg/mL; respectively. Most of derivatives displayed better antibacterial activity than the parent ciprofloxacin against all the tested strains. Compound 6b was the most potent against the highly resistant Gram-negative K.pneumoniae with MIC 16.96 of µg/mL relative to the parent ciprofloxacin (MIC = 29.51 µg/mL). Docking studies of the tested hydrides in the active site of Topo IV enzyme of K.pneumoniae (5EIX) and S.aureus gyrase (2XCT) indicate that they had stronger binding affinity in both enzymes than ciprofloxacin but have different binding interactions. The hybrid 6b could be considered a promising lead compound for finding new dual antibacterial/anticancer agents. Moreover, Compound 8a could be a lead for discovering new dual antibacterial/antifungal agents.
Graphical abstract
Sustaining transformations: changing marine governance, environmental meaning, and ‘left behind’ Brexit narratives on the Yorkshire East Coast
Authors: Antonova Anna S. 
Published: December 2022

AbstractTransformations to sustainability are frequently framed as key to blue growth, but they often engender complex consequences for communities. This article illustrates the role of environmental meaning in these processes through the lens of the Brexit vote on the Yorkshire East Coast. Based on discursive institutionalist analysis of narrative materials from semi-formal interviews conducted in 2017 alongside textual documentation from media, policy, and regional archives, I trace connections between transforming marine governance regimes, environmental meaning, and the British relationship with the EU from the Cod Wars to today. The transformation towards ecosystem-based management in British maritime governance post UNCLOS III left local communities feeling ‘left behind’ not only economically but also in terms of marginalised local meanings of place, labour, and environment. The Brexit vote, in this context, shows the multivalence of transformational processes and the importance of considering environmental meaning as part of their just execution.
An approach for simulating the air brake system of long freight trains based on fluid dynamics
Authors: Ge Xin , Chen Qinghua , Ling Liang , Zhai Wanming , Wang Kaiyun 
Published: December 2022

AbstractAir brake systems are critical equipment for railway trains, which affects the running safety of the trains significantly. To study air braking characteristics of long freight trains, an approach for simulating air brake systems based on fluid dynamics theory was proposed. The structures and working mechanisms of locomotive and wagon air brakes are introduced, and mathematical models of the pipes, brake valves, reservoirs or chambers, cylinders, etc., are presented. Besides, the dynamic motions of parts in the main valve are considered. The simulation model of the whole air brake system is then formulated, and the solving method based on the finite-difference method is used. New efficient pipe boundary conditions without iterations are developed for brake pipes and branch pipes, which can achieve higher computational efficiency. The proposed approach for simulating the air brake system is validated by comparing with published measured data. Simulation results of different train formations indicate that models that consider the dynamic behavior of brake pipes are recommended for predicting the characteristics of long trains under service braking conditions.