bluuebunny/crossref_metadata_2025_split huggingface dataset:
Murine glial progenitor cells transplantation and synthetic PreImplantation Factor (sPIF) reduces inflammation and early motor impairment in ALS mice
Authors: Ambrożkiewicz Karolina A. , Kozłowska Urszula , Haesler Valerie , Barnea Eytan R. , Mueller Martin , Kurpisz Maciej 
Published: March 2022

AbstractAmyotrophic lateral sclerosis (ALS) is a progressive motor neuronal disorder characterized by neuronal degeneration and currently no effective cure is available to stop or delay the disease from progression. Transplantation of murine glial-restricted precursors (mGRPs) is an attractive strategy to modulate ALS development and advancements such as the use of immune modulators could potentially extend graft survival and function. Using a well-established ALS transgenic mouse model (SOD1G93A), we tested mGRPs in combination with the immune modulators synthetic PreImplantation Factor (sPIF), Tacrolimus (Tac), and Costimulatory Blockade (CB). We report that transplantation of mGRPs into the cisterna magna did not result in increased mice survival. The addition of immunomodulatory regimes again did not increase mice lifespan but improved motor functions and sPIF was superior compared to other immune modulators. Immune modulators did not affect mGRPs engraftment significantly but reduced pro-inflammatory cytokine production. Finally, sPIF and CB reduced the number of microglial cells and prevented neuronal number loss. Given the safety profile and a neuroprotective potential of sPIF, we envision its clinical application in near future.
Photo-induced antiferromagnetic-ferromagnetic and spin-state transition in a double-perovskite cobalt oxide thin film
Authors: Zhang Yujun , Katayama Tsukasa , Chikamatsu Akira , Schüßler-Langeheine Christian , Pontius Niko , Hirata Yasuyuki , Takubo Kou , Yamagami Kohei , Ikeda Keisuke , Yamamoto Kohei , Hasegawa Tetsuya , Wadati Hiroki 
Published: March 2022

AbstractInvestigation of ultrafast dynamic behaviors can provide novel insights about the coupling mechanisms among multiple degrees of freedom in condensed matters, such as lattice, magnetism and electronic structure. Here we investigate both the ferromagnetic (FM) and antiferromagnetic (AFM) dynamics of a strongly correlated oxide system, GdBaCo2O5.5 thin film by time-resolved x-ray magnetic circular dichroism in reflectivity (XMCDR) and resonant magnetic x-ray diffraction (RMXD). A photo-induced AFM-FM transition characterized by an increase of the transient XMCDR (sensitive to FM order) beyond the unpumped value and a decay of RMXD (sensitive to AFM order) was observed. The photon-energy dependence of the transient XMCDR and reflectivity could be interpreted as a concomitant photo-induced spin-state transition (SST). The AFM-FM transition and SST couple with each other in the time domain, resulting in unusual dynamic behaviors of the magnetism.
Formation of mononuclear N,O-chelate zirconium complexes by direct insertion of epoxide into tetrakis(dimethylamido)zirconium: highly promising approach for developing an ALD precursor of ZrO2 thin films
Authors: Jiang Jianwei , Choi Sohee , Oh Jaehyun , Choi Jihyun , Sun Ho-Jung , Yoon Sungho 
Published: March 2022

A non-classical and highly effective approach for the preparation of a mononuclear N,O-chelate Zr compounds was developed. The produced precursor enables ALD of ZrO2 at a satisfying growth rate (0.93 Å per cycle).
Antioxidant properties of lactic acid bacteria isolated from traditional fermented yak milk and their probiotic effects on the oxidative senescence ofCaenorhabditis elegans
Authors: Li Wenyuan , Gao Li'e , Huang Wenkang , Ma Ying , Muhammad Ishaq , Hanif Anum , Ding Zitong , Guo Xusheng 
Published: March 2022

The current study was conducted to screen antioxidant lactic acid bacteria strains isolated from traditionally fermented Tibetan yak milk, and to evaluate their probiotic effects on the oxidative senescence of C. elegans.
Significantly lowered activation energy in proton conductor by Mg substitution in a layered Ni metal–organic framework
Authors: Huang Bo , Tan Zhe 
Published: March 2022

A metal–organic framework H2DAB-MgNi(ox)3 was synthesized with the homogeneous distribution of Mg and Ni. By Mg substitution, the H2DAB-MgNi(ox)3 showed enhanced proton conductivity compared to that of H2DAB-Ni2(ox)3 at 95% relative humidity.
Bildgebung in der zirrhotischen Leber – warum, wie und was ist LI-RADS?
Authors: Schreyer Andreas G. , Lüth Stefan , Ringe Kristina I. 
Published: March 2022

ZusammenfassungDie Leberzirrhose als Endstadium einer chronischen Lebererkrankung ist eine häufige Diagnose, vor allem, wenn sie auf viralen Entzündungen und Alkoholabusus basiert. Ein umfassendes
Verständnis dieser Erkrankung sollte eine Voraussetzung für eine gute radiologische Diagnostik sein. Auch das LI-RADS-System, das bei Patienten mit hohem HCC-Risiko und Leberzirrhose
eingesetzt wird, sollte in einer strukturierten radiologischen Befundung Einzug halten.
Congenital Orbital Glial Heterotopia Associated with Clinicopathological Anophthalmia: A Case Report
Authors: Reyes-Godinez Natalia , Tamez-Tamez Veronica E. , Ruiz-Lozano Raul E. , Chavez-Cobian Stephania , Gonzalez-Murillo Eduardo , Villarreal-Reyes Lauro Arturo 
Published: March 2022

AbstractGlial heterotopia (GH) is the presence of glial tissue outside the cranial cavity, without communication with the brain. The orbital location usually presents as eyelid swelling,
strabismus, and proptosis. This is considered a congenital location that usually presents at birth. Its association with anophthalmia is uncommon. We report the case of a 2-day-old male
neonate with left congenital intraorbital lesion presenting with massive proptosis. No eyeball could be seen. Preoperative magnetic resonance imaging disclosed a large and predominantly
cystic mass occupying and protruding from the left orbit without intracranial extension. In the operating theatre, a large amount of fluid was aspirated prior to total resection of the mass.
Chemical analysis of the fluid was compatible with cerebrospinal fluid. Histologically, the tumor was composed of mature neuroglial tissue and ependymal cells. Despite multiple sections, no
choroid plexus or intraocular content was found. The diagnosis of GH with anophthalmia was made.
Können digitale Instrumente wie die Makula-App die AMD-Therapie unterstützen?
Authors: Tripp Anke , Brink Sarah , Lemmen Klaus Dieter , Mussinghoff Peter , Pauleikhoff Daniel 
Published: March 2022

Zusammenfassung
Hintergrund Eine lang andauernde und kontinuierliche Anti-VEGF-Therapie ist bei der neovaskulären altersabhängigen Makuladegeneration (nAMD) der therapeutische „Goldstandard“, um
individuell das bestmögliche Sehvermögen zu erhalten. Das Management der Erkrankung bedeutet für Betroffene und Angehörige eine große Herausforderung. Dabei bleiben Real-Life-Ergebnisse von
Patienten unter der Anti-VEGF-Therapie (IVOM-Therapie) oft hinter denen aus randomisierten klinischen Studien zurück. Das Ziel der vorliegenden Studie war es, zu untersuchen, ob digitale
Instrumente, wie die vom AMD-Netz entwickelte Makula-App 1.0, dies unterstützen können.
Patienten und Methoden Die Ergebnisse einer in die Makula-App 1.0 integrierten Nutzerbefragung (n = 110) sowie einer zusätzlichen direkten Befragung zum Thema „Digitales
Terminmanagement in der IVOM-Therapie“ von Augenärzten (n = 54) und Patienten (n = 60) werden bez. Nutzung und Akzeptanz der Makula-App analysiert.
Ergebnisse Die Befragungen ergaben, dass 79% der Nutzer den Informationen der Makula-App 1.0 vertrauen, 71% finden die App sowie das Terminmanagement hilfreich für den Alltag und 80%
der Nutzer würden die App weiterempfehlen. 52% der Augenärzte und 65% der Patienten sehen einen deutlichen Nutzen zukünftiger digitaler Tools für die Patientenadhärenz. Eine digitale
Terminmanagementfunktion bewerten auch 82% der Ärzte als wichtig.
Schlussfolgerungen Dem Einsatz der Makula-App 1.0 besonders beim Terminmanagement, aber auch als Informationstool, standen die Nutzer mehrheitlich positiv gegenüber, ebenso wie
möglichen Weiterentwicklungen. Auch Augenärzte sehen in digitalen Tools wie der Makula-App 1.0 ein wichtiges Instrument zur Verbesserung des Terminmanagements und der Patientenadhärenz.
Diese positiven Einschätzungen unterstützen die Sinnhaftigkeit der Entwicklung einer interaktiven Plattform Makula-App 2.0, die einen direkten Austausch zwischen Patienten und Augenarzt
ermöglichen kann.
Ausweg aus der Versorgungslücke: Voll
Krankenkassen-finanzierte konservative Adipositas-Therapie
Authors: Frenzel Sarah Victoria , Bach Sophie , Ahrens Swantje , Hellbardt Mario , Hilbert Anja , Stumvoll Michael , Fasshauer Mathias , Schlögl Haiko 
Published: March 2022

Zusammenfassung
Hintergrund Das Leipziger Adipositasmanagement ist das
deutschlandweit erste interdisziplinäre Therapieprogramm für
Patienten mit Adipositas Grad 2 und 3 mit einem langfristigen (i. e.,
4-jährigen) konservativen Behandlungsarm, welches über einen
Vertrag der integrierten Versorgung (IV) komplett durch eine gesetzliche
Krankenkasse finanziert wird. Die vorliegende Arbeit evaluiert die
Effektivität des ersten Abschnitts des Programms mit einer mittleren
Laufzeit von 72 Wochen.
Methoden Von 243 Personen wurden Gewicht, Körperumfänge
sowie ausgewählte metabolische und psychologische Parameter vor Beginn
(t0) und nach Abschluss des ersten Therapieabschnitts
(t1) erhoben. Das methodische Design entspricht einer
prospektiven Auswertung klinischer Real-World-Daten.
Ergebnisse Die Kosten pro Patient betrugen durchschnittlich 2022
€. Die Teilnehmer erreichten eine durchschnittliche Gewichtsreduktion
von 5 kg (95%-Konfidenzintervall (KI) 3,8–6,2) bzw.
4% (KI 3,1–4,9) des Ausgangsgewichts. Der
Hämoglobin-A1c-Wert reduzierte sich in der Gesamtkohorte von
5,9% auf 5,6% und bei Diabetes-mellitus-Patienten von
6,7% auf 6,2%. Weitere metabolische (z. B.
Low-density-Lipoprotein- und Gesamtcholesterin) sowie psychologische
(z. B. Lebensqualität) Parameter verbesserten sich ebenfalls
signifikant.
Schlussfolgerung Die vorliegenden Daten belegen unter
Real-World-Bedingungen, dass ein über einen IV-Vertrag voll
kassenfinanziertes Therapieprogramm bei Adipositas Grad 2 und 3 eine klinisch
relevante Gewichtsreduktion und damit verbundene metabolische Verbesserungen
erreicht. Das Leipziger Adipositasmanagement trägt zur
Schließung der Versorgungslücke, die aktuell für die
Adipositas-Therapie in Deutschland besteht, bei und verbessert die
Qualität der Angebote durch eine individuelle langjährige
Betreuung.
Recovery from Obstetric Anal Sphincter Injury in a Prospective Cohort of First Births
Authors: Attanasio Laura B. , Ranchoff Brittany L. , Long Jaime B. , Kjerulff Kristen H. 
Published: March 2022

Objective To identify risk factors for obstetric anal sphincter injuries (OASIS) for primiparous women who gave birth vaginally and to compare recovery by OASIS status in three domains as follows: (1) physical health and functioning, (2) mental health, and (3) healthcare utilization.
Study Design This secondary analysis used data from 2,013 vaginal births in the First Baby Study, a prospective cohort study of women with first births between 2009 and 2011. Interview data at multiple time points were linked to birth certificate and hospital discharge data. The key exposure of interest was OASIS (3rd or 4th degree perineal laceration, identified in the hospital discharge data; n = 174) versus no OASIS (n = 1,839). We used multivariable logistic regression models to examine the association between OASIS and a range of outcomes including physical health and functioning, depression, and health care utilization, assessed at 1 month and 6 months postpartum.
Results Eight percent of women had OASIS. In adjusted models, there were no differences in general physical health and functioning measures by OASIS (such as fatigue and overall self-rated health), but women with OASIS had higher rates of reporting perineal pain (p < 0.001), accidental stool loss (p = 0.001), and bowel problems (p < 0.001) at 1-month postpartum. By 6-month postpartum, there were no differences in reported physical health and functioning. There were no differences in probable depression at 1- or 6-month postpartum. Women with OASIS were more likely to attend a comprehensive postpartum visit, but there were no other differences in health care utilization by OASIS.
Conclusion Women with OASIS were at increased risk of accidental stool loss, bowel problems, and perineal pain in the immediate postpartum period. Women who had OASIS had similar physical functioning across a range of general health outcomes to women who gave birth vaginally without OASIS.
Key Points
The Relationship between Body Mass Index and Operative Complications in Patients undergoing Immediate Postpartum Tubal Ligation
Authors: Brown Jewel A. , Huff Mallorie L. , Arboleda Bianca L. , Louis Judette M. 
Published: March 2022

Abstract
Objective The objective of this study is to examine the relationship between body mass index (BMI) and complications for patients undergoing postpartum permanent contraception.
Study Design Retrospective cohort study of patients aged 18 or older who had a vaginal delivery at an academic hospital between 2011 and 2016 and underwent a postpartum tubal ligation during the delivery admission. There were three comparative groups: nonobese (BMI ≤ 29 kg/m2), obese (BMI 30–39 kg/m2), and morbidly obese BMI (≥40 kg/m2). The outcome of interest was composite operative complications which included any occurrence of an intraoperative, postoperative, or anesthesia complication.
Results A total of 921 patients were included for analysis. Average operative time was statistically longer for patients in the morbidly obese group (33 minutes) vs. the nonobese (25 minutes) and obese (29 minutes) groups (p < 0.0001). Composite complications were greater for the obese groups, but not statistically significant (5.1 vs. 6 vs. 16%, p = 0.06). Wound complications were significantly greater for the obese groups (0.8 vs. 1.5 vs. 5.5%, p = 0.01). A logistic regression model demonstrated that only operative time was predictive of operative complications.
Conclusion Overall complications of postpartum tubal complications are low; however, our study did demonstrate significantly longer operative time and wound complications for patients with obesity. The findings of our study indicate that postpartum permanent contraception can remain as an option for these patients. Further studies may help identify the best practices to decrease operative time and subsequent wound complications. This study contributes to the limited data regarding obesity and postpartum permanent contraception. We found increased operative time and wound complications for obese patients. Additional studies may identity best practices to decrease these complications. Given our findings of overall low operative complications, postpartum permanent contraception can remain an option for obese patients.
Assessing Clinically Meaningful Hypercoagulability after COVID-19 Vaccination: A Longitudinal Study
Authors: Campello Elena , Bulato Cristiana , Simion Chiara , Spiezia Luca , Radu Claudia Maria , Gavasso Sabrina , Sartorello Francesca , Saggiorato Graziella , Zerbinati Patrizia , Fadin Mariangela , Tormene Daniela , Simioni Paolo 
Published: March 2022

AbstractA large number of daily requests to exclude possible prothrombotic risk factors for coronavirus disease 2019 (COVID-19) vaccines were received. Our aim was to longitudinally evaluate coagulation profiles in a series of healthy subjects who received COVID-19 vaccination and assess hypercoagulability thereafter. Volunteers awaiting a first or second dose of either the ChAdOx1 or BNT162b2 vaccine were enrolled. Venous samples were obtained at baseline (before the vaccine) and longitudinally 3 ± 2 days (T1) and 10 ± 2 days after the vaccine (T2). Global coagulation monitoring was assessed via platelet count, whole blood thromboelastometry and impedance aggregometry, plasma thrombin generation, and anti-platelet factor 4 (PF4)/heparin immunoglobulin G antibodies. One hundred and twenty-two subjects were enrolled (61 [50%] ChAdOx1 and 61 BNT162b2). The ChAdOx1 cohort showed a slight but transient increase in thrombin generation (mainly endogenous thrombin potential [ETP] with thrombomodulin and ETP ratio) at T1, which promptly decreased at T2. In addition, the second dose of either vaccine was associated with increased thrombin peak, ETP with thrombomodulin, and ETP ratio. At baseline, 3.2% of the ChAdOx1 cohort and 1.6% BNT162b2 cohort were positive for PF4/heparin antibodies with a stable titer through T1 and T2. No relevant differences were detected in platelet count and aggregation, or thromboelastometry parameters. No thrombotic or hemorrhagic events occurred. We can confirm that no clinically meaningful hypercoagulability occurred after either vaccine, albeit keeping in mind that thrombin generation may increase in the first days after the second dose of either vaccine and after the first dose of the ChAdOx1 vaccine.
Differences in Hemoglobin A1c during Pregnancy between Non-Hispanic Black versus White Women with Prepregnancy Diabetes
Authors: Venkatesh Kartik K. , Fareed Naleef , Kiefer Miranda K. , Ware Courtney A. , Buschur Elizabeth , Landon Mark B. , Thung Stephen F. , Costantine Maged M. , Gabbe Steven G. , Joseph Joshua J. 
Published: March 2022

Objective The objective of this was to determine whether the change in hemoglobin A1c (HbA1c) from early to late pregnancy differs between non-Hispanic Black and White women with prepregnancy diabetes.
Study Design A retrospective analysis was performed from an integrated prenatal and diabetes care program from 2012 to 2016. We compared HbA1c as a continuous measure and secondarily, HbA1c <6.5%, cross-sectionally, and longitudinally in early (approximately 10 weeks) and late (approximately 31 weeks) pregnancies. Linear and logistic regression were used and adjusted for age, body mass index, White diabetes class, medication use, diabetes type, gestational age at baseline HbA1c measurement, and baseline hemoglobin.
Results Among 296 non-Hispanic Black (35%) and White pregnant women (65%) with prepregnancy diabetes (39% type 1 and 61% type 2), Black women were more likely to experience increased community-level social determinants of health as measured by the Social Vulnerability Index (SVI) and were less likely to have type 1 diabetes and have more severe diabetes versus White women (p < 0.05). Black women had higher mean HbA1c (7.8 vs. 7.4%; beta: 0.75; 95% confidence interval [CI]: 0.30–1.19) and were less likely to have HbA1c < 6.5% at 10 weeks compared with White women (24 vs. 35%; adjusted odds ratio: 0.45; 95% CI: 0.24–0.81) but not after adjusting for SVI. At 31 weeks, both groups had similar mean HbA1c (both 6.5%) and were equally as likely to have HbA1c < 6.5% (57 vs. 54%). From early to late pregnancy, Black women had a higher percentage decrease in HbA1c (1.3 vs. 0.9%; beta = 0.63; 95% CI: 0.27–0.99) and were equally as likely to have an improvement or stable HbA1C < 6.5% from 10 to 31 weeks, with both groups having a similar mean HbA1c (6.5%) at 31 weeks.
Conclusion Despite experiencing greater community-level social determinants of health, Black women with pregestational diabetes had a larger reduction in HbA1c and were able to equally achieve the target of HbA1c < 6.5% by late pregnancy compared with White women as part of an integrated diabetes and prenatal care program.
Key Points
The Impact of Mode of Delivery on Maternal and Neonatal Outcomes during Periviable Birth (22–25 Weeks)
Authors: Roeckner Jared T. , Peterson Erica , Rizzo Jennifer , Flores-Torres Jaime , Odibo Anthony O. , Duncan Jose R. 
Published: March 2022

Objective The objective of our study was to compare the maternal and neonatal complications of periviable birth by the delivery route.
Study Design A retrospective cohort study of periviable deliveries (220/7–256/7weeks) from 2013 to 2020 at a tertiary teaching institution was conducted. Deliveries were grouped by the mode of delivery. Excluded deliveries included pregnancy termination, anomaly, or undesired neonatal resuscitation. The primary composite maternal outcome included death, intensive care admission, sepsis, surgical site infection, unplanned operation, or readmission. Secondary outcomes included maternal blood loss, length of stay, neonatal survival, bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC), patent ductus arteriosus (PDA), and retinopathy of prematurity (ROP). Outcomes were compared using Student's t-test, Wilcoxon–Mann–Whitney and Chi-squared tests. Relative risk (RR) and 95% confidence intervals were calculated with log-binomial regression. p-Values <0.05 were considered significant. Demographic and intervention variables associated with the outcome and the exposure were included in an adjusted relative risk (aRR) model. Subgroup analyses of singleton pregnancies and 220/7 to 236/7 weeks deliveries were conducted.
Results After exclusion, 230 deliveries were included in the cohort. Maternal characteristics were similar between cohorts. For the primary outcome, cesarean delivery was associated with a trend toward increased maternal morbidity (22.6 vs. 10.7%, RR = 2.11 [1.03–4.43], aRR = 1.95 [0.94–4.03], p-value 0.07). Administration of magnesium sulfate, antenatal corticosteroids, and tocolytics were similar between cohorts. Neonatal survival to discharge was not different between the groups (54/83, 65.1% vs. 118/191, 61.8%, aRR = 0.93 [0.77–1.13]). Among the 172 neonates discharged alive, there was no difference in BPD, IVH, NEC, PDA, ROP, or intact survival.
Conclusion Periviable birth has a high rate of maternal morbidity with a trend toward the highest risk among women undergoing cesarean delivery. These risks should be included in shared decision-making.
Key Points