bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social intelligence as moderator in the relation between narcissism and aggression in at‐risk adolescents
Authors: Kim Hyunah , Barry Christopher T. 
Published: November 2022

AbstractThis study examined the moderating role of social intelligence (SI) in the associations of grandiose and vulnerable narcissism (VN) with peer‐reported overt and relational aggression (RA). The sample consisted of 286 adolescents aged 15 to 19 recruited from a residential program for youth who have dropped out of school. Results showed that whereas grandiose narcissism (GN) was related to both forms of aggression, VN was related to neither overt nor RA. However, SI moderated the relation between VN and both forms of aggression such that SI works as either a risk or protective factor for adolescents with higher levels of narcissism depending on the subdimensions of SI and aggression. The findings indicate that SI may play a role in how adolescent peers perceive the behavior of relatively narcissistic individuals.
Heat Transfer Characteristics of the Multicavity Tips at Different Turbulence Levels
Authors: Li Feng , Zhang Weixin , Liu Zhao , Feng Zhenping 
Published: November 2022

Abstract
A comprehensive understanding of the tip heat transfer characteristics is important to the blade tip design. In this work, the heat transfer coefficient (h) data of several multicavity tips was measured using a steady-state method with an infrared camera. The multicavity tips with different cavity numbers were developed by placing ribs into the traditional squealer tip. All the measurements were conducted in a low-speed linear cascade. Moreover, to gain insight into the heat transfer characteristics of the multicavity tips, computational simulations verified by measurements were implemented to acquire the detailed flow structure of these tips. Measurement results show that the h distributions of the multicavity tips are changed by the ribs. Due to the reattachment of the leakage flow, additional high-h regions are observed downstream of the rib. And the h values in the suction-side rim corner increase, especially at near the trailing-edge. A low-h region is found in the corner upstream of the rib. Furthermore, adopting a high freestream turbulence level would enhance the heat transfer. The augment of h values on the tip front portion is more evident than that on the midto-rear part. The validation in a turbine stage indicates that the present data obtained in the stationary condition still could reveal the heat transfer characteristics of these multicavity tips in a rotating condition.
Drying Kinetics and Performance Analysis of Thermal Storage-Based Hybrid Greenhouse Dryer for Uniform Drying of Tomato Flakes
Authors: Ahmad Asim , Prakash Om , Kumar Anil , Hussain Md Shahnawaz 
Published: November 2022

Abstract
This communication focuses on the experimental investigation of mixed heat storage-based hybrid greenhouse dryer. The proposed system is a combination of a solar air heater and a greenhouse dryer. Mixed heat storage material is applied on the bed of the dryer, which is a combination of paraffin wax and black-painted gravel. Tomato flakes were selected for drying in both hybrid system and natural sun drying. Tomato flakes were rehydrated up to 1.29% and 10.10% under hybrid and open modes. Daily drying efficiency for drying tomato flakes in the proposed dryer was 50.18%, while it was 30.02% for open mode. Effective moisture diffusivity was 0.8666 × 10−10 m2/s and 11.650 × 10−10 m2/s for open and hybrid modes. The solar drying process improved physicochemical properties of tomato flakes, resulting in a shelf life extension. This finding highlights the great potential for hybrid solar dryer in the food industry and suggests that it could emerge as an efficient postharvest conserving method for seasonal consumable vegetables and fruits, mostly in developing nations.
Assessing the Potential Increase in the Energy Storage Density of Subsea Hydro-Pneumatic Accumulators Using Carbon Dioxide in Lieu of Air
Authors: Cutajar Charise , Sant Tonio , Briffa Luke Jurgen , Buhagiar Daniel 
Published: November 2022

Abstract
The integration of energy storage systems (ESS) on a large scale is becoming essential to mitigate intermittency issues in power supply from offshore wind farms. This paper deals with an offshore hydro-pneumatic energy storage (HPES) system comprising of a subsea accumulator pre-charged with a compressed gas. The paper applies a simplified thermodynamic model to investigate the potential increase in the energy storage density of the proposed HPES system by replacing air with carbon dioxide (CO2) that is able to undergo a phase change (gas-liquid-gas) during the storage cycle when limiting the peak operating pressure below the critical point. The study is based on a numerical model for simulating the thermodynamics of the entire storage cycle. A sensitivity study is conducted to examine the influence of main operational parameters, primarily the seawater temperature, peak working pressure, and sea depth, on the storage density of the HPES system operating with a dual phase fluid. It is shown that the storage density of HPES accumulators can be increased substantially by using CO2 in lieu of air. The increase in density is found to depend considerably on the seawater temperature and sea depth.
Heat Transfer in a Rotating, Blade-Shaped, Two-Pass Cooling Channel With Various 45-Deg Rib Turbulators and a Tip Turning Vane
Authors: Chen I-Lun , Wright Lesley M. , Han Je-Chin , Krewinkel Robert 
Published: November 2022

Abstract
This work experimentally studied a rotating, blade-shaped, two-pass cooling channel with various 45-deg rib turbulators and a tip-turning vane. The first passage of the cooling channel has an aspect ratio (AR) = 4:1 with the coolant moving radially outward. After a 180-deg blade-shaped tip turn, the coolant flows radially inward into the second passage with an AR = 2:1. The first and second passages are oriented at 50 deg and 105 deg from the rotation direction, respectively. In the tip-turn portion, a tip-turning vane with an oval cross section connects the mid-lines of the two passes. Two orientations of 45 deg angled ribs were considered in this work: unusual and criss-cross. The ribs have a profiled cross section and were placed in-line (P/e = 10, e/H = 0.16) on the leading and trailing surfaces of the channel. Five inlet Reynolds numbers (10,000–45,000) and five rotational speeds (0−400 rpm) were considered in this study, with a maximum rotation number of Ro = 0.38 achieved in the first pass. The results showed that the effect of the turning vane on heat transfer and pressure loss for the 45-deg unusual rib case was insignificant. The overall heat transfer for the criss-cross rib case was slightly increased by the turning vane. For pressure loss, the turning vane provided approximately an 8% reduction in the 45-deg criss-cross rib case, which was the highest in the rib cases. The 45-deg criss-cross ribs presented the highest thermal performance with the turning vane.
Simulating the Effects of Porosity on the D31 Piezoelectric Coefficient of Polyvinylidene Fluoride
Authors: Kloster Jack , Danley Matthew , Struntz Tony , Lai Victor , Zhao Ping 
Published: November 2022

Abstract
A piezoelectric, thin film polyvinylidene fluoride (PVDF) material was developed for application as a blood pressure/flow sensor within an artificial heart. In an effort to increase the piezoelectric coefficient, d31, and maximize the sensitivity of the PVDF material, nanoscale pores were introduced into the thin films. The purpose of the pores was to increase the mechanical strain of the material under compressive loading, and thus increase the charge separation and piezoelectric coefficient. Strain tracking under tensile loading was performed to determine the elastic modulus and Poisson’s ratio of the PVDF material, which were then used to model a simulated material in COMSOL Multiphysics software. Simulations were run to determine the d31 piezoelectric coefficient of the material, and the simulated results were compared with experimental results from a previous study. As porosity of the PVDF films increased, the experimental results showed an increase in d31 from 21.3 pC/N to 51.3 pC/N, or 141%. The simulated results showed an increase in d31 from 16.7 pC/N to 47.2 pC/N, or 183%. The similarity between previous experimental results and novel simulated results suggests that the simulated model used is a reliable method for estimating d31 of PVDF.
Design and Manufacture of a Fluid-Actuated Morphing Winglet Trailing Edge Control Surface
Authors: Vasista Srinivas , Nolte Felix , Schäfer Michael , Riemenschneider Johannes 
Published: November 2022

Abstract
Enabling thin regions in aircraft wings with active control surface functionality is challenging in terms of the integration of high-power actuation systems in regions with small available volumes. This paper details the design of a winglet trailing edge surface composed of miniature fluid-actuated morphing unit structures (FAMoUS) that can potentially enable control surface deflections under the corresponding aerodynamic hinge moments. These FAMoUS actuators consist of a hybrid elastomer and metallic extensible hollow units into which incompressible fluids can be pumped thereby creating displacement and force and thus output work. Position control can be achieved in combination with the appropriate pump systems and shape-feedback sensors. This paper outlines the design, finite element analyses and manufacturing process of a demonstrator currently being fabricated for subsequent testing. These finite element analyses consist of detailed tuned material parameters obtained from testing on the individual unit structure tests as well as the inclusion of hydrostatic fluid elements to determine effective stiffnesses from the pressure-volume relationship between the housing structure and internal fluid. Manufacturing of the demonstrator is to be conducted using composite fabrication and machining techniques to ensure that the demanding tolerances and surface qualities are to be maintained. Outcomes of the manufacturing process and initial testing results show bimorph behavior under fluid pressure.
3D Printed Flexible Dielectric Electroactive Polymer Sensors
Authors: Rodriguez David Gonzalez , Maynard Cole , Hernandez Julio , O’Brien Corey , Tallman Tyler N. , Newell Brittany , Garcia Jose 
Published: November 2022

Abstract
Flexible sensors have demonstrated great potential for utilization in many industrial applications due to their ability to be produced in complex shapes. Sensors are employed to monitor and detect changes in the surrounding environment or the structure itself. A great majority of these flexible structures are produced by casting processes, since they are generally composed of silicone materials due to their high elasticity and flexibility. Unfortunately, the casting process is time consuming, and it limits the development of complex geometries reducing the advantages of silicone materials. 3D printed flexible sensors have demonstrated great potential for utilization in a variety of different applications including healthcare, environmental sensing, and industrial applications. In recent years, research on these topics has increased to meet low-cost sensing needs due to the development of innovative materials and printing techniques that reduce cost, production time, and enhance the electrical and mechanical properties of the sensors. This paper presents a 3D printed flexible dielectric electroactive polymer (DEAP) sensor capable of producing an output signal based on the deformation caused by external forces. Three different conductive flexible filaments were tested, using one commercial filament and two custom-made filaments, a comparison of its sensing behavior is also presented herein. Additionally, computational simulations were done to evaluate the performance of the produced sensors, evaluating the capacitance change of the entire structure. This work demonstrates the production of 3D printed flexible sensors and studies the behavior of new customizable conductive flexible filaments. Both manufactured sensors were produced using fused deposition modeling (FDM) techniques.
Evaluating the feasibility, experiences, facilitators of and barriers to carers and volunteers delivering Namaste Care to people with dementia in their own home: a qualitative interview study in the UK and the Netherlands
Authors: Haaksma Miriam L , O'Driscoll Colette , Joling Karlijn J , Achterberg Wilco P , Francke Anneke L , van der Steen Jenny T , Smaling Hanneke J A 
Published: November 2022

ObjectivesTo evaluate the feasibility, facilitators of and barriers to delivering Namaste Care by volunteers and family carers to community-dwelling people with dementia, and to map family carers and volunteers’ experiences with the programme.DesignQualitative interview study with two phases: (1) preparation phase; (2) pilot phase.SettingPrivate residences of community-dwelling people with dementia in the UK and the Netherlands.ParticipantsFamily carers and volunteers of community-dwelling people with dementia (phase 1: 36 Dutch interviews, phase 2: 9 Dutch and 16 UK interviews).InterventionNamaste Care is a multicomponent psychosocial programme, originally developed for people with dementia residing in long-term care facilities. Meaningful activities were offered by carers and volunteers. Each person with dementia was offered 10 one-hour sessions.ResultsPhase 1: Namaste Care was deemed feasible for community-dwelling people with dementia and no major adaptations to the programme were considered necessary. Phase 2: perceived effects of Namaste Care on people with dementia included improved mood and increased interaction. The programme appeared enriching for both family carers and volunteers, providing joy, respite from care and new insights for coping with challenging behaviour. A flexible attitude of the Namaste provider facilitated its delivery. High caregiver burden and a strained relationship between the family carer and person with dementia were considered barriers. Experiences of family carers and volunteers with Namaste Care were very positive (mean satisfaction rating: 8.7 out of 10, SD=0.9, range 7–10).ConclusionWe recommend offering Namaste Care delivered by volunteers, preferably multiple sessions per week of 1.5–2 hours to optimise quality of life of community-dwelling people with dementia. Working with well-matched, flexible Namaste providers is pivotal. Family involvement should be encouraged, although the extent should be adapted depending on preference, caregiver burden and the relationship between the family carer and the person with dementia.Trial registration numberNL5570
Cost-effectiveness of recombinant tissue-type plasminogen activator for acute ischaemic stroke with unknown time of onset: a Markov modelling analysis from the Chinese and US perspectives
Authors: Zhao Songfeng , Cheng Yuhong , Tong Xin , Han Mingyang , Ji Linjin , Che Yuxiong , Hu Weiwu , Liu Aihua 
Published: November 2022

ObjectiveThe effectiveness of MRI-guided intravenous recombinant tissue-type plasminogen activator (r-tPA) for acute ischaemic stroke (AIS) with an unknown time of onset has been demonstrated by the WAKE-UP Trial. We aim to evaluate its long-term cost-effectiveness from the perspective of Chinese and US healthcare payers.MethodsA combination of decision tree and Markov model was built to project lifetime costs and quality-adjusted life-years (QALYs) associated with intravenous r-tPA or placebo treatment. Model inputs including the transition probabilities, costs and utilities were derived from the WAKE-UP Trial, similar cost-effectiveness studies and other published sources. To compare intravenous r-tPA to placebo, we calculated incremental costs, incremental QALYs and incremental cost-effectiveness ratio (ICER). One-way sensitivity, probabilistic sensitivity and subgroup analyses were performed to evaluate uncertainty in the results.ResultsIn China, intravenous r-tPA gained an additional lifetime QALY of 0.293 with an additional cost of the Chinese Yuan (¥) of 7871 when compared with placebo, resulting in an ICER of ¥26 870 (US$3894)/QALY. In the USA, intravenous r-tPA yielded a higher QALY (difference: 0.430) and lower cost (difference: ¥−4563) when compared with placebo. In probabilistic sensitivity analyses, intravenous r-tPA had a 97.8% and 99.8% probability of being cost-effective or cost-saving in China and the USA, respectively. These findings remained robust under one-way sensitivity and subgroup analysis except for patients with a National Institute of Health Stroke Scale Score of less than 4, between 11 and 16, and over 16.ConclusionsMRI-guided intravenous r-tPA for patients with AIS with an unknown time of onset is cost-effective in China and cost-saving in the USA.
Supporting the ambulance service to safely convey fewer patients to hospital by developing a risk prediction tool: Risk of Adverse Outcomes after a Suspected Seizure (RADOSS)—protocol for the mixed-methods observational RADOSS project
Authors: Noble Adam J , Mason Suzanne M , Bonnett Laura J , Reuber Markus , Wright Jasmine , Pilbery Richard , Jacques Richard M , Simpson Rebecca M , Campbell Richard , Fuller Alison , Marson Anthony Guy , Dickson Jon Mark 
Published: November 2022

IntroductionAmbulances services are asked to further reduce avoidable conveyances to emergency departments (EDs). Risk of Adverse Outcomes after a Suspected Seizure seeks to support this by: (1) clarifying the risks of conveyance and non-conveyance, and (2) developing a risk prediction tool for clinicians to use ‘on scene’ to estimate the benefits an individual would receive if conveyed to ED and risks if not.Methods and analysisMixed-methods, multi-work package (WP) project. For WP1 and WP2 we shall use an existing linked data set that tracks urgent and emergency care (UEC) use of persons served by one English regional ambulance service. Risk tools are specific to clinical scenarios. We shall use suspected seizures in adults as an exemplar.WP1: Form a cohort of patients cared for a seizure by the service during 2019/2020. It, and nested Knowledge Exchange workshops with clinicians and service users, will allow us to: determine the proportions following conveyance and non-conveyance that die and/or recontact UEC system within 3 (/30) days; quantify the proportion of conveyed incidents resulting in ‘avoidable ED attendances’ (AA); optimise risk tool development; and develop statistical models that, using information available ‘on scene’, predict the risk of death/recontact with the UEC system within 3 (/30) days and the likelihood of an attendance at ED resulting in an AA.WP2: Form a cohort of patients cared for a seizure during 2021/2022 to ‘temporally’ validate the WP1 predictive models.WP3: Complete the ‘next steps’ workshops with stakeholders. Using nominal group techniques, finalise plans to develop the risk tool for clinical use and its evaluation.Ethics and disseminationWP1a and WP2 will be conducted under database ethical approval (IRAS 307353) and Confidentiality Advisory Group (22/CAG/0019) approval. WP1b and WP3 have approval from the University of Liverpool Central Research Ethics Committee (11450). We shall engage in proactive dissemination and knowledge mobilisation to share findings with stakeholders and maximise evidence usage.
Surpass Intracranial Aneurysm Embolization System Pivotal Trial to Treat Large or Giant Wide-Neck Aneurysms – SCENT: 3-year outcomes
Authors: Hanel Ricardo A. , Cortez Gustavo M , Coon Alexander L , Kan Peter , Taussky Philipp , Wakhloo Ajay K , Welch Babu G , Dogan Aclan , Bain Mark , De Vries Joost , Ebersole Koji , Meyers Philip M 
Published: November 2022

BackgroundTo report the 3-year safety and effectiveness of the Surpass Streamline flow diverter in the SCENT trial (Surpass Intracranial Aneurysm Embolization System Pivotal Trial to Treat Large or Giant Wide-Neck Aneurysms).MethodsThe Surpass Streamline flow diverter device was evaluated in a multicenter, prospective, single-arm, non-randomized interventional trial including patients with uncoilable or previously treated but failed aneurysms of the intracranial internal carotid artery. 3-year outcomes were tabulated with descriptive statistics and compared with 1-year outcomes.ResultsOf 180 patients in the modified intent-to-treat (mITT) cohort, 36-month clinical and angiographic follow-up was available in 134 and 117 cases, respectively. Effectiveness endpoint of complete aneurysm occlusion without clinically significant stenosis or retreatment was met in 71.8% (79/110, 95% CI 62.4% to 80.0%) of cases. Safety composite endpoint was 12.2% (22/180) over the 3-year period, with two major safety events (ipsilateral ischemic strokes) occurring between 12–36 months. Complete aneurysm occlusion was noted in 77.8% (91/117), and 99.1% (116/117) of the patients demonstrated adequate aneurysm occlusion (complete occlusion or neck residual). There were four cases (2.2%) of aneurysm rupture, all occurring within the first month of the index procedure. Target aneurysm retreatment rate was 2.8% (5/180).ConclusionThe present findings support the long-term safety and effectiveness of the Surpass Streamline flow diverter device.Trial registrationNCT01716117.
Human Metastatic Cholangiocarcinoma Patient-Derived Xenografts and Tumoroids for Preclinical Drug Evaluation
Authors: Serra-Camprubí Queralt , Verdaguer Helena , Oliveros Winona , Lupión-Garcia Núria , Llop-Guevara Alba , Molina Cristina , Vila-Casadesús Maria , Turpin Anthony , Neuzillet Cindy , Frigola Joan , Querol Jessica , Yáñez-Bartolomé Mariana , Castet Florian , Fabregat-Franco Carles , Escudero-Iriarte Carmen , Escorihuela Marta , Arenas Enrique J. , Bernadó-Morales Cristina , Haro Noemí , Giles Francis J. , Pozo Óscar J. , Miquel Josep M. , Nuciforo Paolo G. , Vivancos Ana , Melé Marta , Serra Violeta , Arribas Joaquín , Tabernero Josep , Peiró Sandra , Macarulla Teresa , Tian Tian V. 
Published: November 2022

Abstract

Purpose:
Cholangiocarcinoma (CCA) is usually diagnosed at advanced stages, with limited therapeutic options. Preclinical models focused on unresectable metastatic CCA are necessary to develop rational treatments. Pathogenic mutations in IDH1/2, ARID1A/B, BAP1, and BRCA1/2 have been identified in 30%–50% of patients with CCA. Several types of tumor cells harboring these mutations exhibit homologous recombination deficiency (HRD) phenotype with enhanced sensitivity to PARP inhibitors (PARPi). However, PARPi treatment has not yet been tested for effectiveness in patient-derived models of advanced CCA.

Experimental Design:
We have established a collection of patient-derived xenografts from patients with unresectable metastatic CCA (CCA_PDX). The CCA_PDXs were characterized at both histopathologic and genomic levels. We optimized a protocol to generate CCA tumoroids from CCA_PDXs. We tested the effects of PARPis in both CCA tumoroids and CCA_PDXs. Finally, we used the RAD51 assay to evaluate the HRD status of CCA tissues.

Results:
This collection of CCA_PDXs recapitulates the histopathologic and molecular features of their original tumors. PARPi treatments inhibited the growth of CCA tumoroids and CCA_PDXs with pathogenic mutations of BRCA2, but not those with mutations of IDH1, ARID1A, or BAP1. In line with these findings, only CCA_PDX and CCA patient biopsy samples with mutations of BRCA2 showed RAD51 scores compatible with HRD.

Conclusions:
Our results suggest that patients with advanced CCA with pathogenic mutations of BRCA2, but not those with mutations of IDH1, ARID1A, or BAP1, are likely to benefit from PARPi therapy. This collection of CCA_PDXs provides new opportunities for evaluating drug response and prioritizing clinical trials.