bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perception of mHealth Intervention for Psychoeducational Support Among Nigerian Women Receiving Chemotherapy for Breast Cancer: A Qualitative Study
Authors: Akingbade Oluwadamilare , Adediran Victoria , Somoye Ibironke Elizabeth , Alade Adetutu Sefinat , Chow Ka Ming 
Published: February 2022

Abstract
Background Women diagnosed with BC receiving chemotherapy have reported various side effects, which adversely affect their psychological state. Evidence suggests that psychoeducational interventions (PEIs) delivered through mobile phones might effectively provide psychosocial support for this population. However, there is a lack of evidence on Nigerian women's perception of mHealth PEI, which prompted this study.MethodA multi-centre exploratory qualitative study was conducted among women with BC who had completed chemotherapy at two tertiary hospitals in Nigeria. Face-to-face focus group interviews were conducted at the oncology clinics. Data were collected using a semi-structured interview guide until data saturation was reached. Data were analysed using thematic analysis. Results Thirty-two women were recruited, with seven focus group interviews conducted. The participants were between 22 and 75 years old and mostly diagnosed with Stage III BC. Four main themes emerged from the data analysis, including experiences of BC diagnosis and treatment phase, patients’ needs during chemotherapy, coping with chemotherapy and perception of mHealth intervention for psychoeducational support. The participants found that mHealth intervention is acceptable, and the suggested contents include information on chemotherapy, how to deal with the fear of chemotherapy, nutritious diet locally available and information on exercise.Conclusion BC diagnosis was devastating, and psychological disturbances were experienced while receiving chemotherapy, but the participants perceived that mHealth intervention could provide psychological and informational support. This study will help design a culturally appropriate mHealth PEI for this population.
Effect of Folic Acid Conjugated Silver Nanoparticles in Treatment of RA like Adjuvant Arthritis in Rats
Authors: Ahmed Hajar K. , Elbeialy Adel A. , Mansour Ahmad M. , Elzomor Hala , Abosaif Amany I. 
Published: February 2022

Abstract
Objective: Nanomedicine has become one of the promising research areas, opening new horizons in disease diagnosis and treatment. Recent years have witnessed a surge in the development of nanomedicine for combating rheumatoid arthritis (RA), the most common autoimmune arthritis. RA is characterized by progressive inflammation and persistent synovitis, leading to joint destruction, functional incapability, and ultimately disability. Although there has been a tremendous evolution in disease assess¬ment and treatment, many patients still fail to attain remission. Therefore, developing new drugs that specifically target inflamed joints and simultaneously attenuate other possible damages to healthy tissues is indispensable. This study was done to evaluate the potential of folic acid conjugated silver nanoparticles (FA-AgNPs) as RA therapy.Methods: In the CFA-arthritic rat model, FA-AgNPs & methotrexate were administered for 8 consecutive weeks. Therapeutic efficacy was evaluated by measuring paw volume, ESR, CRP, TNF-α, and IL-6 levels. For safety concerns, CBC, liver, and renal function tests were evaluated. Joints histological assessment was also carried out.Results: FA-AgNPs significantly reduced paw volume, paw weight, ESR, CRP, RF, TNF-α, and IL-6 levels compared with arthritic non-treated rats, demonstrating good anti-inflammatory activity. Likewise, histology of tarsal joints depicted comparatively lesser inflammatory cellular infiltration and diminished cartilage erosions. Methotrexate displayed comparable results. In contrast to methotrexate, FA-AgNPs showed normal CBC & significantly improved liver and renal function tests. Conclusion: FA-AgNPs exhibited substantial anti-arthritic activity. This notable anti-arthritic potential of FA-AgNPs was as good as the current standard treatment of MTX with higher biosafety.
Evaluation of General and Specific Combining Ability for Doubled Haploid Lines in Sweet Pepper (Capsicum Annuum L.)
Authors: Bayati Azam Zare , Shariatpanahi Mehran E. , Mostafavi Khodadad , Miri Seied Mehdi 
Published: February 2022

Abstract
Hybrid cultivars are commercially and economically important; hence, too much effort needed to improve the quality and quantity of hybrids. In this research project, general (GCA) and specific (SCA) combining ability of 32 doubled haploid (DH) lines of sweet pepper produced via microspore embryogenesis were evaluated. The DH lines were crossed with the top cross parent as the tester to evaluate general combining ability (GCA). Traits including morphological and yield-related characteristics to assess the general combining ability of lines were recorded and analyzed. The half-diallel mating crosses were performed using GCA based on the selected seven DH lines for SCA evaluation. Mean squares of GCA and SCA values were highly significant for most of the characters. DH55 line indicated the highest positive GCA for average yield per plant, moreover, the highest positive SCA was obtained for 55×64 hybrid. The ratio of \(\frac{MS \left(GCA\right)}{MS \left(SCA\right)}\) showed the non-additive gene actions in controlling all traits except fruit width and length and seed fresh weight. According to the results of specific combining ability of DH lines, four F1 hybrids were selected for new cultivar registration. The results obtained in the present study are applicable to release new F1- hybrids, which can be more reliable than those hybrids introduced by conventional selfing programs in sweet pepper due to 100% genetic purity of DH lines.
A novel missense mutation in the SLC26A4 gene in a chinese family with enlarged vestibular aqueducts
Authors: He Xiaohui , Zhao Shaozhi , Shi Lin , Lu Yitong , Yang Yintong , Zhang Xinwen 
Published: February 2022

Abstract
Background: SLC26A4 gene is closely related to enlarged vestibular aqueducts. Its homozygous mutation or compound heterozygous mutation may cause deafness and seriously affect the patient's life. As far as we know, this is the first reported pathogenic or probable pathogenic for the missense mutation. Our studies expand the mutation site of SLC26A4 gene and provide genetic counseling for the patient's family.Methods: The patients who came to our hospital for hearing test and accompanied by bilateral hearing abnormalities were collected for 15 genetic tests for hereditary deafness. Those who are positive on chip screening will be verified by first-generation sequencing, combined with family history, hearing test, and computerized tomography (CT) of the temporal bone to diagnose the enlarged vestibular aqueducts. If necessary, perform second-generation sequencing.Results: The patient failed the two hearing screenings on both sides, computerized tomography diagnosed enlarged vestibular aqueduct (>1.5 mm). Two pathogenic mutations, c.1174A>T and c.2069T>A were detected in SLC26A4. The heterozygous c.2069T>A mutation of SLC26A4 gene is a novel missense mutation that has been submitted to the clinvar website, Variation ID：1048780.Conclusion: Our findings enriched SLC26A4 gene spectrum and support previous studies that the enlarged vestibular aqueducts can be caused by a compound heterozygous mutation in SLC26A4.
Optimizing plant density and balancing NPK inputs in combination with innovative fertilizer product for sustainable maize production in North China Plain.
Authors: Zhao Shuaixiang , Feyissa Tesema , Hailong Ma , Zhiping Duan , Zhang Weifeng 
Published: February 2022

Abstract
Excessive NPK inputs but low grain yield and high environmental impact are common in maize production in North China Plain (NCP). The objective of our study was to test whether a combined strategy of optimizing plant density, balancing NPK input, and innovating one-time fertilizer products could achieve a more sustainable maize production in NCP. Thus, a field experiment was conducted at Luanna County NCP with the treatments of unfertilized control (CK), farmer practice (FP, conventional plant density and NPK input), conventional one-time urea-based coated fertilizer (CF, optimized plant density and NPK input), and five newly designed innovative one-time NPK fertilizers of ammonium sulphate and urea synergy (IF, optimized plant density and NPK input), innovative fertilizer with various additives of urea inhibitors (IF+UI), double inhibitors (IF+DI), micro-organisms (IF+MI), and trace elements (IF+TE). The grain yield, nitrogen sustainability indicators (nitrogen use efficiency NUE, partial factor productivity of nitrogen PFPN, and nitrogen surplus), and cost-benefits analysis were measured and calculated over the maize growing season of 2020. Results had shown that on average the five innovative fertilizers (IF, IF+UI, IF+DI, IF+MI, and IF+TE) and CF that had optimized plant density and NPK input achieved 13.5%, 98.6%, 105.9%, 37.4% higher yield, PFPN, NUE, net-benefits as well as 67.5% lower N surplus compared with FP respectively. Notably, the innovative fertilizer with various effective additives (IF+UI, IF+DI, IF+MI, and IF+TE) which can be commonly found in the fertilizer market hadn’t resulted in an improvement in yield and NUE rather a greater cost and small net benefits in comparison to IF. In summary, our study highlighted the effectiveness of the combined strategy of optimized plant density, balancing NPK input, and innovative NPK products on sustainable maize production in NCP, however, the innovative fertilizers with effective additives should be properly selected for better economic benefits.
Predicting personal risk of developing breast and prostate cancer from routine check-up data using survival analysis trees
Authors: Coster Dan , Fisher Eyal , Shenhar-Tsarfaty Shani , Menes Tehillah , Berliner Shlomo , Rogowski Ori , Zeltser David , Shapira Itzhak , Halperin Eran , Rosset Saharon , Gorfine Malka , Shamir Ron 
Published: February 2022

Abstract
The challenge of survival prediction is ubiquitous in industry and medicine. Few methods are available for survival prediction of time varying data. Here we propose a novel method for this problem, using a random forest of survival trees for left truncated and right-censored data. We demonstrated the advantage of our method on prediction of breast cancer and prostate gland cancer risk among healthy individuals by analyzing routine laboratory measurements, vital signs and age. We analyzed electronic medical records of 20,317 healthy individuals who underwent routine checkups and identified those who later developed cancer. In cross-validation, our method predicted future prostate and breast cancers six months before diagnosis with an area under the ROC curve of 0.62±0.05 and 0.6±0.03 respectively, outperforming standard random forest, Cox-regression model and a single survival tree. Our results suggest that computational analysis of data on healthy individuals can improve the detection of those at risk of future cancer development.
Introgression of anthracnose resistance Co-4 gene in elite French bean (Phaseolus vulgaris L.) background using linked molecular marker SY20
Authors: . Bansuli 
Published: February 2022

Abstract
French bean is one of the most important staple foods in many parts of the world. Among several bacterial, fungal and viral diseases, anthracnose caused by Colletotrichum lindemuthianum is the most widespread and severe disease of French bean. Therefore, the present study was undertaken with the objective of introgression of important bean anthracnose resistance gene Co-4 in elite cultivar. Hybridisation between resistant genotype, TO having bean anthracnose resistance gene Co-4 and elite cultivar Arka Komal was done. Cross Arka Komal × TO was further advanced to generate F1, BC1F1, BC2F1 and BC2F2 plants. Testing of hybridity of the resultant F1, BC1F1, BC2F1 and BC2F2 plants/pods using gene linked SCAR marker SY20 resulted in identification of 46 gene-positive BC2F2. Further foreground selection revealed lack of segregation for the target gene Co-4 in 16 progenies. Screening of progenies following detached pod and germinated seed dip methods using race 3 of C. lindemuthianum validated Co-4 imparted resistance in all the 16 BC2F3 progenies. Agronomic evaluation of 16 Co-4 gene-positive BC2F4 progenies for 8 qualitative traits and 9 quantitative traits identified AKTO 4, AKTO 5, AKTO 7 and AKTO 43 progenies as having better elite background. These can either be used as donors of resistance gene for further introgression and gene pyramiding or can further be advanced following backcrossing to develop essentially derived variety of elite parent, Arka Komal.
Factors that Influence the Decision to Vape among Indigenous Youth
Authors: Struik Laura L. , Werstuik Saige-Taylor , Dow-Fleisner Sarah , Ben-David Shelly , Sundstrom Alyssa 
Published: February 2022

Abstract
Background: The use of e-cigarettes (vaping) among Indigenous youth is much higher than that of their non-Indigenous counterparts, which has raised the concerns of various Indigenous scholars and communities. To better understand the most salient constructs that influence Indigenous youth decision-making around vaping, we co-created a qualitative research study with a Syilx First Nation community that was guided by the Unified Theory of Behavior (UTB). Methods: Through semi-structured interviews and a sharing circle, we gathered the perspectives and experiences of 16 Syilx youth. After an initial collaborative coding and training session, the interviews were transcribed and coded by Indigenous peer researchers using Nvivo. The final set of inductive themes were collaboratively developed. Results: Syilx youth reported that vaping decision-making is underpinned by colonialism, and the historical disproportionate impact of the tobacco industry. The youth spoke to several individual determinants that influence intentions to vape (e.g., vaping helps you cope), determinants that translate intentions to vape to decision to vape (e.g., access to vaping), individual determinants that influence intentions to not vape (e.g., family/community connectedness), and determinants that translate intentions to vape to decision to vape (e.g., access to supportive adults/band). The youth suggested that prevention efforts must first be informed by an understanding of why Indigenous youth vape.Conclusions: Vaping decision-making among Indigenous youth is underpinned by their cultures, contexts, and histories. In order to effectively address vaping among Indigenous youth, continued engagement of Indigenous youth in planning, developing, implementing, and evaluating both prevention and policies efforts is a necessity.
Electrocatalytic Selenium Redox Reaction for High-Mass-Loading Zinc-Selenium Batteries with Improved Kinetics and Selenium Utilization
Authors: Ma Longtao , Ying Yiran , Chen Shengmei , Chen Ze , Li Hongfei , Huang Haitao , Zhao Lingzhi , ZHI Chunyi 
Published: February 2022

Abstract
The consensus practice in research of high energy density energy storage devices is to simultaneously achieve high areal capacity and high intrinsic specific capacity. Increasing the areal capacity of batteries necessitates the maximization of their mass loading. However, batteries usually deliver mass loading-dependent electrochemical performance. Take selenium (Se) cathode with a theoretically high specific capacity as an example, Se reaction kinetics, utilization and cycling lifespan seriously deteriorate with increased Se mass loading. Here, we propose an electrocatalytic Se reduction/oxidation reaction strategy to realize high-Se-loading Zn||Se batteries with fast kinetics and high Se utilization. Specifically, the synergetic effects of Cu and Co transition-metal species inside channel structure of host can effectively immobilize and catalytically convert Sen during cycling, which thus facilitates Se utilization and 6-electron (Se4+ \(\leftrightarrow\) Se2–) conversion kinetics. In particular, the Cu[Co(CN)6] host exhibits a remarkably low energy barrier (1.63 kJ·mol−1) and low Tafel slope (95.23 mV·dec−1) for the Se reduction, and highest current response for Se oxidation. Accordingly, the Zn battery employing Se-in-Cu[Co(CN)6] cathode delivers a capacity of 664.7 mAh⋅g−1 at 0.2 A⋅g−1, an excellent rate capability with 430.6 mAh⋅g−1 achieved even at 10 A⋅g−1, and long-cyclic life over 6000 cycles with 90.6% capacity retention. Furthermore, an A-h-level (~1350 mAh) Zn||Se pouch-type battery with high Se loading (~12.3 mg(Se)⋅cm−2) shows a high Se utilization of 3.3 % and outstanding cyclic stability with 9.4 % initial capacity retained after 400 cycles at exceedin 98 % Coulombic efficiency.
Computational Thinking and Educational Robotics Integrated into Project-Based Learning
Authors: Valls Albert 
Published: February 2022

Abstract

In the context of the STEAM discipline in education, subjects tend to fall into contextualized activities or projects. Educational robotics and computational thinking have the potential to be subjects, although not all educational programs provide for it. Although the use of technology and programming platforms is widespread, it is not common practice to integrate computational thinking and educational robotics into the official curriculum in the field of secondary school.That is why this paper continues with the initial project of integrating computational thinking and educational robotics in the La Salle Bonanova school, a secondary school in Barcelona, Spain. This study presents project-based learning which the main focus is the development of skills related to STEAM subjects and the acquisition of computational thinking knowledge in a 2nd year of use in a block-based programming environment.
Urban vultures preferentially roost at sites surrounded by more developed land cover and lower deer carcass density.
Authors: Partridge Hannah , Gagné Sara 
Published: February 2022

Abstract
Context. Land cover changes resulting from urbanization alter habitat structure and resource availability. Vultures provide ecosystem services such as nutrient cycling and may help limit disease transmission, making them an important feature of urban areas. Urbanization may have positive and negative impacts on vultures, such as increasing foraging opportunities and decreasing nesting success, complicating our understanding of the effect of urbanization on these species. Objectives. We examined how local and landscape features affect roost attendance of black vultures (Coragyps atratus) and turkey vultures (Cathartes aura) to better understand the factors that play a role in site selection and habitat and landscape use. Methods. We counted the number of vultures at twenty-nine roosting sites in the Charlotte Metropolitan Area, NC once a month between November and March over two years. At each roosting site, we measured roosting structure height, vegetation height, and open space, and calculated the amounts of developed land cover, open water, developed-forest edge density, and deer carcass density in surrounding landscapes of 0.4 to 20km radii. Results. The best model for roost attendance included wind speed, vegetation height, developed land cover within 15km, developed-forest edge density within 15km, deer carcass density within 15 and 20km, and survey date. Developed land cover was associated with higher roost attendance while other variables were associated with lower roost attendance. Conclusions. The effects of landscape variables on roost attendance suggests urban vultures are relying more on trash and anthropogenic food sources, which may alter nutrient cycling, disease dynamics, and reproductive success.
Complete Genome Sequence of Amazon Lily Mosaic Virus Isolated From Amaryllis (Hippeastrum Hybridum Hort.)
Authors: Lin Chian-Chi , Chen Tsung-Chi 
Published: February 2022

Abstract
In April 2011, a virus was isolated by single lesion isolation on Chenopodium quinoa leaves from an amaryllis plant with chlorotic ringspots at a private garden in Changhua County, Taiwan. The Illumina MiSeq sequencing system was used to determine the genomic nucleotide (nt) sequence of the virus. A de novo assembled contig with 9377 nt, containing a putative open reading frame of the potyviral polyprotein, was annotated as the potyvirus Amazon lily mosaic virus (ALiMV) by sharing 95.5% nt identity with a partial genomic sequence of ALiMV available in GenBank. Therefore, the amaryllis virus was designated as ALiMV-TW. Through 5´ and 3´ rapid amplification of cDNA ends (RACEs), the complete genome sequence of ALiMV-TW was clarified as 9618 nt. Sequence analysis indicated that the genome and polyprotein of ALiMV-TW share 52.3%-65.1% nt identity and 30.1%-64.2% aa identity with those of other potyviruses, respectively. This is the first report to elucidate the complete genome sequence of Amazon lily mosaic virus.
Cross-cultural validation of the Dutch version of the Vertigo Symptom Scale – Short Form questionnaire in general practice
Authors: Noordzij Anisa S. Y. , Terluin Berend , Wouden Johannes C. van der , Horst Henriëtte E. van der , Essery Rosie , Yardley Lucy , Maarsingh Otto R. , Vugt Vincent A. van 
Published: February 2022

Abstract
Background The Vertigo Symptom Scale – Short Form (VSS-SF) is a widely used questionnaire to measure vestibular symptoms such as dizziness and vertigo. We aimed to translate and cross-culturally validate the Dutch version of the VSS-SF. Methods We performed a psychometric evaluation study in general practice. First, we followed international guidelines to translate the VSS-SF into Dutch. We assessed the comprehensibility of the Dutch translation by interviewing 20 older adults with dizziness. Next, we used data from patients aged 50 years and older with chronic dizziness who participated in British (n=296) and Dutch (n=322) randomized controlled trials to evaluate measurement invariance. In this cross-cultural validation analysis we used ordinal logistic regression to detect potential differential item functioning (DIF) and differential test functioning (DTF). ResultsAccording to the 20 patients we interviewed, the Dutch translation of the VSS-SF was clear and comprehensible. We detected small DIF on 2 of the 15 items of the questionnaire. However, the effect of these DIFs on the overall scale was negligible. ConclusionsWe developed a comprehensible and cross-culturally valid Dutch translation of the VSS-SF. This questionnaire can be used to assess vestibular symptoms in general practice.
Marker-Assisted Backcrossing For Introgression of Broad-Spectrum Bacterial Leaf Blight Resistance In MR297 Malaysian Elite Variety
Authors: Aljumaili Saba Jasim , Rafii M. Y. , Zaharah S. S. , Khairulmazmi A. , Yusuff Oladosu 
Published: February 2022

Abstract
One of the most critical aspects of marker-assisted backcross breeding is recurrent parent genome recovery (RPGR). RPGR ensures that only the genes of interest are retained without further segregation in the recombined progenies while the unwanted genomic segments are completely deleted. This experiment aimed to introgress multiple bacterial leaf blight (BLB) resistance genes against using marker-assisted backcross breeding. Four Xoo resistance genes viz: Xa21, xa13, xa5, and Xa4 from IRBB60 were introgressed into the genetic background of MR297 Malaysian, which is considered a high yield. Polymorphic functional linked markers to target genes and SSR markers were used for both foreground and background selection. The percentage of RPGR in the selected lines, a background selection was adopted using 83 approved polymorphic microsatellites markers. The study results reveal RPGR of 81.94%, 92.30%, and 95.32% at BC1F1, BC2F1, and BC2F2, respectively. Marker-assisted backcross breeding often shows a faster introgression resistance gene than traditional breeding. The introgression of four BLB resistance genes Xa21, xa13, xa5, and Xa4 in the nine newly developed lines would provide durable and broad-spectrum resistance against the bacterial leaf blight. The newly created lines were suggested for commercial production as new rice varieties.