bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histidine Ligated Iron‐Sulfur Peptides
Authors: Valer Luca , Rossetto Daniele , Parkkila Taylor , Sebastianelli Lorenzo , Guella Graziano , Hendricks Amber L. , Cowan James A. , Sang Lingzi , Mansy Sheref S. 
Published: June 2022

AbstractIron‐sulfur clusters are thought to be ancient cofactors that could have played a role in early protometabolic systems. Thus far, redox active, prebiotically plausible iron‐sulfur clusters have always contained cysteine ligands to the cluster. However, extant iron‐sulfur proteins can be found to exploit other modes of binding, including ligation by histidine residues, as seen with [2Fe‐2S] Rieske and MitoNEET proteins. Here, we investigated the ability of cysteine‐ and histidine‐containing peptides to coordinate a mononuclear Fe2+ center and a [2Fe‐2S] cluster and compare their properties with purified iron‐sulfur proteins. The iron‐sulfur peptides were characterized by UV‐vis, circular dichroism, and paramagnetic NMR spectroscopies and cyclic voltammetry. Small (≤6 amino acids) peptides can coordinate [2Fe‐2S] clusters through a combination of cysteine and histidine residues with similar reduction potentials as their corresponding proteins. Such complexes may have been important for early cell‐like systems.
Why double‐kissing crush should be preferred over culotte for two‐stent bifurcation stenting
Authors: Simsek Bahadir , Brilakis Emmanouil S. 
Published: June 2022

Key Points
The thrombogenicity of the double‐kissing (DK) crush and culotte bifurcation stenting techniques was assessed with three different stent types using optical coherence tomography in a porcine arteriovenous shunt model.
Culotte had malapposition in the proximal main vessel, which was not observed in DK crush. Culotte also had more thrombus in the bifurcation area compared with DK crush.
DK crush may be preferable to culotte when performing bifurcation stenting using an upfront two‐stent strategy.
Should we use invasive fractional flow reserve (FFR), imaging, or both to determine the significance of a “borderline” lesion?
Authors: Grines Cindy L. , Kern Morton J. 
Published: June 2022

Key Points
Anatomy and physiology do not correlate well for the borderline stenosis.
FFR (and NHPR) identify patients who will benefit more than those undergoing percutaneous coronary intervention (PCI) based on anatomy alone.
For the borderline lesion in the SIHD patient, apply physiology for when to treat, and anatomy (imaging) for how to treat.
Aggregation Modes of Chiral Diketopyrrolo[3,4‐c]pyrrole Dyes in Solution and Thin Films
Authors: Albano Gianluigi , Zinna Francesco , Urraci Francesco , Capozzi Maria Annunziata M. , Pescitelli Gennaro , Punzi Angela , Di Bari Lorenzo , Farinola Gianluca M. 
Published: June 2022

AbstractThe chiroptical features of chiral diketopyrrolo[3,4‐c]pyrrole (DPP) derivatives have been only marginally investigated to date. In this regard, we have synthesizedad hocfour chiral DPP dyes, functionalized with enantiopure alkyl groups from natural sources either on the lactam moieties or on the terminal positions of the π‐conjugated backbone, to promote an efficient self‐assembly into chiral supramolecular structures. For each of them, the aggregation modes has been investigated by absorbance and ECD spectroscopies in conditions of solution aggregation and on thin films, considering the effects of deposition technique (drop casting vs. spin coating) and post‐deposition operations (solvent and thermal annealing). The effect of the structure of lateral π‐conjugated units attached to the central DPP scaffold, as well as that of the position of the alkyl chiral group, has been assessed. ECD revealed superior capability, compared to absorbance spectroscopy, to provide information on the aggregation modes and to detect the possible co‐existence of multiple aggregation pathways.
First‐order inverse filters: Implementations using a single voltage conveyor and potential applications
Authors: Psychalinos Costas , Minaei Shahram , Yesil Abdullah 
Published: June 2022

SummaryFirst‐order low pass and high pass inverse filter topologies, offering simplicity and independent adjustment of the gain and the characteristic frequency, are introduced in this work. These features are offered thanks to the terminals properties of the second generation voltage conveyor. In addition, possible applications of these types of filters are exploited. The behavior of a control system, where these filters are incorporated, is evaluated in both frequency and time‐domain using the Cadence IC design suite.
Arterial stiffness indices in children and adolescents with type 1 diabetes mellitus: A meta‐analysis
Authors: Christoforidis Athanasios , Georeli Irene , Dimitriadou Meropi , Galli‐Tsinopoulou Assimina , Stabouli Stella 
Published: June 2022

AbstractAimsCardiovascular disease (CVD) represents the most frequent cause of morbidity and mortality among patients with type 1 diabetes mellitus (T1DM). Our aim was to review the evidence and conduct a meta‐analysis assessing measures of arterial stiffness by pulse wave velocity (PWV) and augmentation index (AIx) in children and adolescents with T1DM compared to healthy controls.MethodsPubMed and the Cochrane Library were searched for relevant studies published up to 10 May 2021.ResultsTwenty‐one studies were finally included in the meta‐analysis. The T1DM group had significantly higher carotid to femoral PWV levels than that of the control group (mean difference [d]: 0.53 CI: 0.35–0.71, P < 0.00001) but with a fair heterogeneity (I 2:73%). By omitting one study with marked heterogeneity, mean difference in cfPWV remained significantly increased in the T1DM group compared to the control group (mean difference [d]: 0.37 CI: 0.27–0.48, P < 0.00001) but with improved heterogeneity (I2 = 26%). Regarding Aix, the T1DM group had a significantly higher AI@75 index than that of the control group (mean difference [d]: 0.28 CI: 0.17–0.39, P < 0.00001) and with no heterogeneity (I 2 = 8%).ConclusionsYouths with T1DM show increased arterial stiffness, either as increased carotid‐femoral pulse wave velocity or increased augmentation index, early in their course of life compared to healthy controls.PROSPERO registration numberCRD42021253236
Effect of Molecular Shape on the Properties of Indolo[3,2,1‐jk]carbazole‐Based Compounds
Authors: Wang Yuannan , Zhang Gang 
Published: June 2022

AbstractA concave indolo[3,2,1‐jk]carbazole‐based compound was synthesized and characterized, which was further compared with the property of its planar congener. The results reveal that the change in molecular shape alters the molecular electronic structure, thus leading to the reduced aromaticity and divergent energy levels of frontier molecular orbitals of the concave compound. Moreover, the bowl‐shaped molecule demonstrates a blue‐shift in the UV/Vis absorption and a red‐shift in the weakened fluorescence emission due to the vibration of the concave face.
Old World Vultures Reflect Effects of Environmental Pollutants Through Human Encroachment
Authors: Krüger Sonja C. , Botha Andre , Bowerman William , Coverdale Brent , Gore Meredith L. , van den Heever Linda , Shaffer L. Jen , Smit-Robinson Hanneline , Thompson Lindy J. , Ottinger Mary Ann 
Published: June 2022

Abstract
African wildlife face challenges from many stressors including current and emerging contaminants, habitat and resource loss, poaching, intentional and unintentional poisoning, and climate-related environmental change. The plight of African vultures exemplifies these challenges due to environmental contaminants and other stressors acting on individuals and populations that are already threatened or endangered. Many of these threats emanate from increasing human population size and settlement density, habitat loss from changing land use for agriculture, residential areas, and industry, and climate-related changes in resource availability. Environmental chemicals that are hazardous include legacy chemicals, emerging chemicals of concern, and high-volume-use chemicals that are employed as weed killers and in other agricultural applications. Furthermore, there are differences in risk for species living in close proximity to humans or in areas affected by habitat loss, climate, and industry. Monitoring programs are essential to track the status of nesting pairs, offspring survival, longevity, and lifetime productivity. This is important for long-lived birds, such as vultures, that may be especially vulnerable to chronic exposure to chemicals as obligate scavengers. Furthermore, their position in the food web may increase risk due to biomagnification of chemicals. We review the primary chemical hazards to Old World vultures and the interacting stressors affecting these and other birds. Habitat is a major consideration for vultures, with tree-nesters and cliff-nesters potentially experiencing different risks of exposure to environmental chemicals. The present review provides information from long-term monitoring programs and discusses a range of these threats and their effects on vulture populations. Environ Toxicol Chem 2022;41:1586–1603. © 2022 SETAC
Identification of a novelPHIP::BRAFgene fusion in infantile fibrosarcoma
Authors: Boulouadnine Boutaina , de Villenfagne Laurence , Galant Christine , Sciot Raphael , Brichard Bénédicte , Demoulin Jean‐Baptiste 
Published: June 2022

AbstractIntroductionTheETV6::NTRK3fusion is the most common gene alteration in infantile fibrosarcoma, a soft tissue tumor affecting patients under two years of age. Less frequently, these tumors harbor fusions of genes encoding other kinases, such asBRAF, which activates MEK in the mitogen‐activated protein kinase pathway. The identification and characterization of these oncogenes are crucial to facilitate diagnosis, validate new treatments, and better understand the pathophysiology of these neoplasms.MethodsHerein, we analyzed anETV6::NTRK3‐negative infantile fibrosarcoma from a 5‐day‐old patient by RNA‐sequencing to identify new fusion transcripts. Functional exploration of the fusion of interest was performed byin vitroassays to study its activity, oncogenicity, and sensitivity to the MEK inhibitor trametinib.ResultsWe identified a novel fusion involving thePHIPandBRAFgenes. The corresponding fusion protein constitutively activated the mitogen‐activated protein kinase pathway, resulting in fibroblast transformation. Treatment of transfected cells with trametinib effectively inhibited signaling byPHIP::BRAF.ConclusionPHIP::BRAFis a novel fusion oncogene that can be targeted by trametinib in infantile fibrosarcoma.
Comparison of the mechanical properties and anchoring performance of polyvinylidene fluoride and polypropylene barbed sutures for tendon repair
Authors: Huang Yihan , Cadet Edwin R. , King Martin W. , Cole Jacqueline H. 
Published: June 2022

AbstractPolyvinylidene fluoride (PVDF) has been considered as an alternative suture material to replace polypropylene (PP) due to its superior biocompatibility and mechanical properties, but it has never been examined for use in barbed sutures, particularly for tendon repair. This study fabricated size 2–0 PVDF and PP bidirectional barbed sutures and compared their mechanical properties and anchoring performance in patellar tendons. The mechanical properties were evaluated via tensile testing, and the anchoring performance of the barbed sutures was assessed by a tendon suture pullout test. Sixty porcine patellar tendons were harvested, transected to mimic a full‐thickness injury, and repaired using a cross‐locked cruciate suturing technique. The ultimate tensile force was 60% higher for the PVDF barbed sutures (22.4 ± 2.1 N) than for the PP barbed sutures (14.0 ± 1.7 N). The maximum pullout force was 35% higher for PVDF barbed sutures (70.8 ± 7.8 N) than for PP barbed sutures (52.4 ± 5.8 N). The force needed to form a 2‐mm gap, indicative of repair failure, was similar between the PVDF (29.2 ± 5.0 N) and PP (25.6 ± 3.1 N) barbed sutures, but both were greater than the 2‐mm‐gap forces for non‐barbed sutures of the same size. In this study, PVDF barbed sutures provided better mechanical properties and improved tissue anchoring performance compared to the barbed PP sutures for porcine patellar tendon repair, demonstrating that PVDF monofilament sutures can be barbed and used effectively for tendon repair.
Olfactory dysfunction in COVID‐19, new insights from a cohort of 353 patients: The ANOSVID study
Authors: Mercier Julien , Osman Molka , Bouiller Kevin , Tipirdamaz Can , Gendrin Vincent , Chirouze Catherine , Lepiller Quentin , Bouvier Elodie , Royer Pierre‐Yves , Pierron Alix , Toko Lynda , Plantin Julie , Kadiane‐Oussou N'dri‐Juliette , Zayet Souheil , Klopfenstein Timothée 
Published: June 2022

AbstractOlfactory disorders (OD) pathogenesis, underlying conditions, and prognostic in coronavirus disease 2019 (COVID‐19) remain partially described. ANOSVID is a retrospective study in Nord Franche‐Comté Hospital (France) that included COVID‐19 patients from March 1 2020 to May 31 2020. The aim was to compare COVID‐19 patients with OD (OD group) and patients without OD (no‐OD group). A second analysis compared patients with anosmia (high OD group) and patients with hyposmia or no OD (low or no‐OD group). The OD group presented less cardiovascular and other respiratory diseases compared to the no‐OD group (odds ratio [OR] = 0.536 [0.293–0.981], p = 0.041 and OR = 0.222 [0.056–0.874], p = 0.037 respectively). Moreover, history of malignancy was less present in the high OD group compared with the low or no‐OD group (OR = 0.170 [0.064–0.455], p < 0.001). The main associated symptoms (OR > 5) with OD were loss of taste (OR = 24.059 [13.474–42.959], p = 0.000) and cacosmia (OR = 5.821 [2.246–15.085], p < 0.001). Most of all ORs decreased in the second analysis, especially for general, digestive, and ENT symptoms. Only two ORs increased: headache (OR = 2.697 [1.746–4.167], p < 0.001) and facial pain (OR = 2.901 [1.441–5.842], p = 0.002). The high OD group had a higher creatinine clearance CKD than the low or no‐OD group (89.0 ± 21.1 vs. 81.0 ± 20.5, p = 0.040). No significant difference was found concerning the virological, radiological, and severity criteria. OD patients seem to have less comorbidity, especially better cardiovascular and renal function. Associated symptoms with OD were mostly neurological symptoms. We did not find a significant relationship between OD and less severity in COVID‐19 possibly due to methodological bias.
Evaluation of nutritional quality of complementary foods formulated from blends of Nigerian yellow maize (Zea mays), soybean (Glycine max) and crayfish (Procambarus clarkii)
Authors: Adegbusi Halid Sheriff , Ismail Amin , Mohd Esa Norhaizan , Mat Daud Zulfitri Azuan 
Published: June 2022

AbstractBACKGROUNDPlant‐based complementary foods (CFs) supply insufficient amount of nutrients to meet recommended nutrient intakes for 6–23‐month‐old children. The present study determined the nutritional quality of CFs formulated from blends of Nigerian yellow maize (Zea mays), soybean (Glycine max) and crayfish (Procambarus clarkii). Three CFs were formulated; namely, maize flour (MF, 100:0% w/w), blends of maize and soybean flour (MSF, 72:28% w/w), and maize, soybean and crayfish flour (MSCF, 80:10:10% w/w). Nutritional quality was evaluated using analyses of chemical composition of CFs and of protein quality of complementary food diets. Data were compared by multivariate analysis of variance and significantly differentiated. Nine selected nutritional criteria were used to decide the CF that had best nutritional characteristics compared to MF and fortified wheat flour (FWMF).RESULTSTotal scores obtained from the selected nutritional criteria ranked MSCF, with total score of 15, as the lowest and thus it was considered to have the most desirable nutritional characteristics compared to MF, MSF and FWMF, which had respective total scores of 31, 22 and 20.CONCLUSIONConclusively, MSCF may serve as a better alternative CF for MF, MSC and FWMF. The present study has produced a potential alternative cost‐effective and adequate CF, formulated from crayfish (P. clarkii) supplementation of locally available blend of yellow maize (Z. mays) and soybean (G. max), for the poor human population, aiming to encourage the consumption of animal‐sourced CF for alleviating the prevalence of childhood undernutrition. © 2022 Society of Chemical Industry.
Knowledge management process, infrastructure, and system quality as resilient strategies to respond to COVID‐19 pandemic challenges: Evidence from higher educational institutions in India
Authors: Sivagnanam Pavithra , Pillai Arul Ramanatha , Elangovan Rajesh , Parayitam Satyanarayana 
Published: June 2022

AbstractThe COVID‐19 global pandemic has adversely affected educational institutions worldwide, resulting in frequent mandatory lockdowns and social distancing rules. After waiting for a brief period, most organizations, including educational institutions, moved their operations from traditional in‐class to virtual, web‐based teaching‐learning. As a result of unprecedented change, faculty, students, and administrators faced several challenges. However, how the educational institutions were coping with this challenging situation remained an important question. To address this, we present Knowledge Management Process (KMP), Knowledge Management System Infrastructure (KMSINF), and Knowledge Management System Quality (KMSQU) as resilient strategies to convert the challenges into opportunities. Using the KM processes and practices, a complex model is constructed to positively influence employee commitment, performance, and job satisfaction. A survey instrument was used to collect data from 747 faculty members from 14 higher educational institutions in the southern part of India. After testing the measurement properties using the Lisrel package of structural equation modeling, the complex model was tested using Hayes PROCESS macros. The results indicate (i) KMP is positively related to performance and employee commitment, (ii) employee commitment mediates the relationship between KMP and performance, (iii) KMSINF moderates the relationship between KMP and employee commitment, (iv) KMSQU moderates the moderated relationship between KMP and KMSINF in influencing the employee commitment, and (v) performance is positively related to job satisfaction. The results suggest that KM processes, system infrastructure, and system quality are effective, resilient strategies to bring educational institutions to normal functioning during the present global pandemic. The implications for KM, employee commitment, and job satisfaction are discussed.
Cannabinoid Receptor Type 1 in Parkinson's Disease: A Positron Emission Tomography Study with [18F]FMPEP‐d2
Authors: Ajalin Riikka M. , Al‐Abdulrasul Haidar , Tuisku Jouni M. , Hirvonen Jussi E.S. , Vahlberg Tero , Lahdenpohja Salla , Rinne Juha O. , Brück Anna E. 
Published: June 2022

ABSTRACTBackgroundThe endocannabinoid system is a widespread neuromodulatory system affecting several biological functions and processes. High densities of type 1 cannabinoid (CB1) receptors and endocannabinoids are found in basal ganglia, which makes them an interesting target group for drug development in basal ganglia disorders such as Parkinson's disease (PD).ObjectiveThe aim of this study was to investigate CB1 receptors in PD with [18F]FMPEP‐d2 positron emission tomography (PET) and the effect of dopaminergic medication on the [18F]FMPEP‐d2 binding.MethodsThe data consisted of 16 subjects with PD and 10 healthy control subjects (HCs). All participants underwent a [18F]FMPEP‐d2 high‐resolution research tomograph PET examination for the quantitative assessment of cerebral binding to CB1 receptors. To investigate the effect of dopaminergic medication on the [18F]FMPEP‐d2 binding, 15 subjects with PD underwent [18F]FMPEP‐d2 PET twice, both on and off antiparkinsonian medication.Results[18F]FMPEP‐d2 distribution volume was significantly lower in the off scan compared with the on scan in basal ganglia, thalamus, hippocampus, and amygdala (P < 0.05). Distribution volume was lower in subjects with PD off than in HCs globally (P < 0.05), but not higher than in HCs in any brain region.ConclusionsSubjects with PD have lower CB1 receptor availability compared with HCs. PD medication increases CB1 receptor toward normal levels. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
Potential Building Blocks for 1,4‐Dihydro‐N‐heteroacenes
Authors: John Plater M. , Harrison William T. A. 
Published: June 2022

AbstractStudies have been performed aimed at the synthesis ofN‐heteroacenes via substitution reactions of 4,5‐difluoro‐1,2‐dinitrobenzene with a diamine. The fluorine atoms are displaced first, followed by an activated nitro group. Two intermediates have been characterised by X‐ray single‐crystal structure determinations. Their intermolecular interactions were examined by Hirshfeld surfaces to assess their suitability for organic molecular electronics. The high reactivity of the phenazine, which is prone to oxidise and rearrange, as are displacement products prepared from it, is explained by the formation of acis‐aci‐nitroform from the secondary amine of the phenazine and a nitro group.
Enhance the mechanical properties of epoxy resin reinforced with functionalized graphene oxide nanocomposites prepared by atom transfer radical polymerization
Authors: Yang Guorui , Ma Yan , Liu Chen , Zhang Lanyue , Li Xiangwei , Du Weifeng , Shang Lei , Ao Yuhui 
Published: June 2022

AbstractInspired by the strengthening effect of nanoparticles and the toughening effect of block polymers, we prepared a block polymer filler with graphene oxide (GO) as the main body by surface initiate atom transfer radical polymerization (SI‐ATRP). In the side groups of the main molecular segment of this block polymer, glycidyl methacrylate (GMA) fragment and N‐(3,4‐bis([tert‐butyldimethylsilyl]oxy)phenethyl)methacrylamide (DOPAmTBDMS) fragment can promote dispersion and toughening respectively. The molecular structure was characterized by Fourier transform infrared and X‐ray photoelectron spectroscopy. After the modified GO was added to the epoxy composite, the mechanical properties of the composite could be significantly improved. The toughness of epoxy composites was enhanced by crack deflection of the matrix. When the added amount of modified GO was 0.25 wt%, the flexural strength reached 151 MPa, which was 37.27% higher than pure epoxy composite. The tensile strength and izod impact strength were increased by 50.56% and 69.89%, respectively. These are attributed to the strengthening and toughening effects of GO and the side groups on it. This research had potential application value in the field of resin fillers and in combination with carbon fiber, metal and other materials.