bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of farm size on cost and profitability in dairy cattle farming
Authors: Sarica Deniz , Demircan Vecdi , Dalgic Asli , Aydin Ozgur , Koknaroglu Hayati 
Published: June 2022

Abstract
Dairy cattle production is a substantial industry in Türkiye’s livestock sector, with a significant economic impact. Because of its proximity to Türkiye’s major market zone, the Mediterranean and Aegean regions, the province of Isparta can develop its milk production capacity and make investments in dairy production. Therefore, the purpose of this study was to look into the economic structures of dairy farms of various sizes in Isparta, a major milk-producing region in Türkiye. For this aim, production costs and drivers of profitability for dairy farms were examined. The study included data from 159 dairy cattle farms operating in the production period 2020–2021 in the designated area. Dairy farms were separated into three groups based on size and analysed consequently. The findings revealed that total feed consumption was higher on small-scale farms, while milk production was lower. Feed costs were the highest portion of the cost among the cost items (72.86%), followed by permanent labour costs (7.12%). Furthermore, milk sales income (64.39%) was the largest contributor to the average income in terms of the gross product value. Aside from milk production, it was discovered that cattle value appreciation (24.12%) increased farm income. Consequently, as farm size increased, production costs per animal unit fell while net profit rose. Finally, feed is the most significant input that boosts milk production costs. Also, larger farms were found to be more profitable in the study area. Thus, it was concluded that policies that could have a favourable effect on an increase in the cattle population on the farm should be advanced in the study area.
Changes in non-oscillatory features of the cortical sensorimotor rhythm in Parkinson's disease across age
Authors: Vinding Mikkel , Eriksson Allison , Manting Cassia , Waldthaler Josefine , Ferreira Daniel , Ingvar Martin , Svenningsson Per , Lundqvist Daniel 
Published: June 2022

Abstract
Parkinson's disease (PD) is associated with changes in neural activity in the sensorimotor alpha and beta bands. Using magnetoencephalography (MEG), we investigated the role of spontaneous neuronal activity within the somatosensory cortex in a large cohort of early- to mid-stage PD patients (N = 78) and age- and sex matched healthy controls (N = 60) using source reconstructed resting-state MEG. We quantified features of the time series data in terms of oscillatory alpha power, beta power, and 1/f broadband characteristics using power spectral density, and also characterised transient beta burst events in the time-domain signals. We examined the relationship between these signal features and the patients’ disease state, symptom severity, age, sex, and cortical thickness.PD patients and healthy controls differed on PSD broadband characteristics, with PD patients showing a steeper 1/f exponential slope and higher 1/f offset. PD patients further showed a steeper age-related decrease in the burst rate. Out of all the signal features of the sensorimotor activity, only burst rate was associated with increased severity of bradykinesia. Our study shows that general non-oscillatory features (broadband PSD slope and offset) of the sensorimotor signals are related to disease state and oscillatory burst rate scales with symptom severity in PD.
The effect and comparison of training in ethical decision-making through lectures and group discussions on moral reasoning, moral distress and moral sensitivity in nurses: A clinical randomized controlled trial
Authors: Khaghanizadeh Morteza , Koohi Aliakbar , Ebadi Abbas , Vahedian-Azimi Amir 
Published: June 2022

Abstract
Background: Ethical decision‑making and behavior of nurses are major factors that can affect the quality of nursing care. Moral development of nurses to making better ethical decision-making is an essential element for managing the care process. The main aim of this study was to examine and comparison the effect of training in ethical decision-making through lectures and group discussions on nurses' moral reasoning, moral distress and moral sensitivity.Methods: In this randomized clinical trial study with a pre- and post-test design, 66 nurses with moral reasoning scores lower than the average of the community were randomly assigned into three equal groups (n=22) including two experimental groups and one control group. Ethical decision-making training to experimental groups was provided through the lectures and group discussions. While, the control group did not receive any training. Data were collected using sociodemographic questionnaire, the nursing dilemma test (NDT), the moral distress scale (MDS) and the moral sensitivity questionnaire (MSQ). Unadjusted and adjusted binary logistic regression analysis was reported using the odds ratio (OR) and 95% confidence intervals.Results: In adjusted regression analysis after intervention, the nursing principled thinking (NPT) score was significantly increased in group discussions vs. lectures group (OR: 13.078, 95%CI: 3.238-15.954, P=0.008), lectures group vs. control group (OR: 14.329, 95%CI: 2.005-16.171, P<0.001) and group discussions vs. control group (OR: 18.01, 95%CI: 5.834-22.15, P<0.001). The moral sensitivity score was significantly increased in group discussions vs. lectures group (OR: 10.874, 95%CI: 6.043-12.886, P=0.005) and group discussions vs. control group (OR: 13.077, 95%CI: 8.454-16.774, P=0.002). However, the moral distress score was significantly decreased in lectures group vs. control group (OR: 0.105, 95%CI: 0.015-0.717, P=0.021) and group discussions vs. control group (OR: 0.089, 95%CI: 0.015-0.547, P=0.009). Conclusions: The results of this study indicate that ethical decision-making training is effective on empowerment of ethical reasoning. Whereas the group discussion was also effective on increasing the ethical sensitivity, it is recommended the training plan provided in this study to be held as workshop for all nurses in health and treatment centers and placed in curricular plan of nursing students.Registration: This randomized clinical trial was registered in Iranian Registry of Clinical Trials under code (IRCT2015122116163N5) in 02/07/2016.
Sleep apnea predicts cardiovascular death in patients with Marfan syndrome
A cohort study
Authors: Gessler Nele , Wohlmuth Peter , Anwar Omar , Debus Sebastian , Eickholt Christian , Gunawardene Melanie , Hakmi Samer , Heitmann Kathrin , Rybczynski Meike , Schueler Helke , Sheikhzadeh Sara , Tigges Eike , Wiest Gunther , Willems Stephan , Adam Ekaterina , Von Kodolitsch Yskert 
Published: June 2022

Abstract
Background
Identification of possible risk factors is crucial to optimize predictive, preventive, and personalized medicine (PPPM) in Marfan syndrome (MFS). Despite a well known relationship between sleep apnea and MFS, the impact of sleep apnea on cardiovascular death and on aortic events remains unclear.
Methods
This is an investigator-initiated study with long-term follow-up data of 105 MFS patients. All participants were screened for sleep apnea regardless of symptoms. The primary endpoint was cardiovascular death and the secondary outcome was the occurrence of aortic events.
Results
Sleep apnea with an apnea-hypopnea-index (AHI) > 5/h was observed in 21.0% (22/105) with mild sleep apnea in 13% (14/105) and moderate to severe sleep apnea in 7.6% (8/105). After a median follow-up of 7.76 years [interquartile range: 6.84, 8.41], 10% (10/105) had died, with cardiovascular cause of death in 80% (8/10). After adjusting for age and body-mass-index (BMI), the AHI-score emerged as an independent risk factor for cardiovascular death (hazard ratio 1.712, 95%-confidence interval [1.061–2.761], p = 0.0276). The secondary outcome of aortic events occurred in 33% (35/105). There was no effect of the AHI-score on aortic events after adjusting for age and BMI (hazard ratio 0.965, 95%-confidence interval [0.617–1.509]), possibly due to a high number of patients with prior aortic surgery.
Interpretation:
Sleep apnea shows to be independently predictive of cardiovascular death in patients with Marfan syndrome. These findings highlight the necessity of early sleep apnea screening in MFS patients as an important adjunct to the PPPM management of the disease.
The Dressing Method and Dynamics of soliton solutions for the Kundu-Eckhaus equation
Authors: Chai Xuedong , Zhang Yufeng 
Published: June 2022

Abstract
The boundary value problem for focusing Kundu-Eckhaus equation with non-zero boundary conditions is studied by the Dbar dressing method in this work. A Dbar problem with non-canonical normalization condition is introduced to investigate the soliton solution. The eigenfunction of Dbar problem is meromorphic outside annulus with center 0, which is used to construct the Lax pair of the Kundu-Eckhaus equation with non-zero boundary conditions, which is a crucial step to further search for the soliton solution. Furthermore, the original nonlinear evolution equation and conservation law are obtained by means of choosing a special distribution matrix. Moreover, the N -soliton solutions of focusing Kundu-Eckhaus equation with non-zero boundary conditions are discussed based on the symmetries and distribution. As concrete examples, the dynamic behaviors of the one-breather solution and the two-breather solution are analyzed graphically by considering different parameters.PACS 05.45.Yv, 03.75.Lm, 42.65.Tg
Assessing the implementation fidelity of HPV self-collection offered by Community Health Workers during home visits (the EMA strategy): a case study in a low-middle resource setting in Argentina
Authors: Paolino Melisa , Antelo Victoria Sanchez , Cuberli Milca , Curotto Mariana , Pera Anabella Le , Binder Fernando , Mazzadi Juan David , Firmenich Beatriz , Arrossi Silvina 
Published: June 2022

Abstract
BackgroundIn Argentina, HPV self-collection offered by Community Health Workers was demonstrated to be effective to improve cervical cancer screening uptake. Based on these findings, the EMA strategy was scaled-up in nine Argentinian provinces. However, there is no evidence about the degree of fidelity -in relation to the core components proposed by the National Program on Cervical Cancer Prevention- with which this strategy was implemented in the new jurisdictions. We carried out a fidelity evaluation of the EMA strategy scaling-up aimed at evaluating the level of adherence to the core components of the EMA strategy, and how different moderating factors affected the implementation fidelity. Methods This descriptive study used a multi-methods approach involving quantitative and qualitative evaluations of the implementation fidelity using the Conceptual Framework for Implementation Fidelity. Evaluation of the degree of adherence to the core components of the EMA strategy was carried out through the analysis of a self-administered survey of health promoters (HPs), observations, and secondary data from the national screening information system. The analysis of moderating factors was carried out through analysis of field notes, and semi-structured interviews with key stakeholders. ResultsOur results showed that the core components with highest fidelity were “Training”, Sample Handling, and Transportation. Regarding the Offer of HPV self-collection, we found some adaptations such as locations in which HPs offered HPV self-collection, and fewer pieces of information provided to women during the offer. In the Follow-up and Treatment core component we found a reduced adherence to triage and colposcopy. Some contextual factors had a negative impact on implementation fidelity, such as urban insecurity and the reduction in the number of HPs that offered HPV self-collection. Moderating factors that contributed to achieve high level of fidelity included a well-defined strategy with clear steps to follow, permanent feedback and high level of engagement among implementers.ConclusionsOut study shows how the analysis of fidelity and adaptations of HPV self-collection in real-world contexts are key to measure and maximize its effectiveness in Low-middle income settings.
New family of CV states of definite parity and their metrological power
Authors: Podoshvedov Mikhail S. , Podoshvedov Sergey A. 
Published: June 2022

Abstract
We introduce a family of new continuous variable (CV) states of definite parity originating from even single-mode squeezed vacuum (SMSV) state by subtracting an arbitrary number of photons from it. A beam splitter (BS) with arbitrary transmittance and reflectance parameters serves as a hub for redirecting input photons in an indistinguishable manner to the output and measuring modes followed by probabilistic measurement, thereby converting the initial SMSV photon distribution into new one after we know the number of registered photons in auхilliary mode. Depending on the parity of the subtracted photons, the family of the generated states is divided into two subfamilies, that is, into even and odd according to the parity of the Fock state subtracted. The family of the CV states is determined solely by one SMSV parameter, which inevitably decreases during their implementation. The algorithm of the quantum engineering can generate macroscopic CV states with a larger average number of photons (say, 4000 and even more) and quantum Fisher information of observable measuring the number of photons many times more (say, from tens of times for small practical values of the squeezing ratio to ≈4 for extremely high squeezing amplitude) than one of the original SMSV. The potential of the new family of the CV states of a certain parity, to which original SMSV, no doubt, belongs, can become decisive for a new push to implementation of optical quantum metrology protocols.
External Ventricular Drain Placement Is Associated With Lower Mortality After Intracerebral Hemorrhage With Intraventricular Hemorrhage
Authors: Warren Andrew D. , Li Qi , Schwab Kristin , McKaig Brenna , Goldstein Alexa N. , Greenberg Steven M. , Viswanathan Anand , Anderson Christopher , Gurol M. Edip , Patel Aman , Goldstein Joshua N. 
Published: June 2022

Abstract
Background and Aims:
Many patients with intracerebral hemorrhage (ICH) develop intraventricular hemorrhage (IVH), which is associated with higher mortality and worse clinical outcome. External ventricular drains (EVDs) are often placed, but there is little data on how much patients benefit from this intervention. We explored the use, timing, and location of EVD in ICH patients and any association with clinical outcome.
Results
During the study period 2,870 patients presented with primary ICH and 2,486 were included in analyses. Overall, patients were 73 (± 13) years old; 54% were male, and 46% had associated IVH. An EVD was placed in 29% of patients with IVH and 4% of those without. IVH patients with EVD were younger (67 ± 13 vs 74 ± 13, p < 0.001), had larger IVH volumes (17 mL vs 8 mL, p < 0.001), and lower GCS scores (7 vs 10, p < 0.001), compared to those without EVD. 90-day mortality was available in 2,486 (100%) patients, while 90-day mRS was available in 1,673 (67.3%). In univariate analysis, EVD placement was associated with lower likelihood of 90-day mortality (53% vs 59%, p = 0.048), but higher likelihood of poor outcome (88% vs 85%, p < 0.001) in those for whom this was available. Those with poor outcomes underwent faster EVD placement (0.46 days vs. 0.96 days, p = 0.01). In multivariate analysis, EVD placement was associated with lower 90-day mortality (OR 0.19, 95% CI 0.053–0.657, p = 0.009), but not with lower odds of poor outcome (OR 1.64, 95% CI 0.508–5.309, p = 0.4). In multivariate analysis, days to EVD placement was associated with lower 90-day mortality (OR 0.69, 95% CI 0.49–0.96, p = 0.027).
Conclusion
IVH is relatively common after ICH. After controlling for potential confounds, EVD placement is associated with lower mortality, but not clearly with better neurologic outcome. In addition, more rapid EVD placement is associated with higher mortality, potentially reflecting early development of herniation or obstructive hydrocephalus.
Modulation of antichiral edge states in zigzag graphene nanoribbons by side potential
Authors: Yang Jia-En , Lü Xiao-Long , Xie Hang 
Published: June 2022

Abstract
Antichiral edge states induced by the modified Haldane model have been predicted by Colomés and Franz (Physical Review Letters, 2018, 120(8): 086603). By applying the side potential composed of a potential field, staggered electric field, and exchange field along the boundaries of zigzag graphene nanoribbons (zGNRs), we further propose other types of antichiral edge states and investigate their corresponding transport properties. It is found that the side potential could destroy one or two (spin) edge modes, eventually inducing five novel antichiral edge states. By calculating the effect of these external fields separately on the energy band of the zGNRs, the regulatory mechanism has been explained. In addition, based on these induced edge states, we also proposed the spin/charge switcher in the three-terminal device consisting of zGNRs. We believe that these results could be used for the future designs of spintronic devices.
Feature selection method using multi-agent reinforcement learning based on guide agents
Authors: Kim Minwoo , Bae Jinhee , Wang Bohyun , Lim Joon S. 
Published: June 2022

Abstract
In this study, we propose a method to automatically find features from a dataset that are effective for classification or prediction, using a new method called multi-agent reinforcement learning and a guide agent. Each feature of the dataset has one each of main and guide agents, and these agents decide whether to select a feature. Main agents select the optimal features, and guide agents present the criteria for judging the main agents’ actions. After obtaining the main and guide rewards for the features selected by the agents, the main agent that behaves differently from the guide agent, by calculating the learning reward delivered to the main agents, updates their Q-values. The behavior comparison between them helps the main agent decide whether its own behavior is correct, without using other algorithms. After performing this process for each episode, the features are finally selected. The feature selection method proposed in this study uses multiple agents, which reduces the number of actions that each agent can perform and finds optimal features effectively and quickly. Finally, comparative experimental results on multiple datasets show that the proposed method can select effective features for classification and increase the classification accuracy.
Hsa_circ_0053943 drives uveal melanoma progression via regulating N6-methyladenosine modification of EGFR with IGF2BP3
Authors: Zhao Andi , Wang Yue , Wang Zijin , Shao Qing , Gong Qi , Zhu Hui , Liu Lei , Zhang Xiaohan , Shen Shiya , Liu Hu , Chen Xuejuan 
Published: June 2022

Abstract
Background
Increasing studies characterized the critical role of circular RNAs (circRNAs) as regulatory factors in the progression of multiple cancers. Nevertheless, the biological functions of circRNAs and their underlying molecular mechanisms in uveal melanoma (UM) progression remain enigmatic.
Methods
A novel circRNA, circ_0053943, was selected from re-mining UM microarray and quantitative RT-PCR. Functional assays were performed to investigate the roles of circ_0053943 in UM progression both in vitro and in vivo. To further explore the molecular mechanisms of circ_0053943 in UM, we implemented the fluorescence in situ hybridization, RNA pulldown assay, RNA binding protein immunoprecipitation assay, RNA sequencing, co-immunoprecipitation, and dual-luciferase reporter assays.
Results
Circ_0053943 was upregulated in UM and prompted the proliferation and metastatic ability of UM cells in vitro and in vivo. Mechanistically, circ_0053943 could bind to the KH1 and KH2 domains of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), enhancing the function of IGF2BP3 by facilitating the stabilization of target mRNA. RNA sequencing assay identified epidermal growth factor receptor (EGFR) as a target gene of circ_0053943 and IGF2BP3 at the transcriptional level. Rescue assays revealed that circ_0053943 exerts its biologic function by stabilizing EGFR mRNA and regulating downstream the MAPK/ERK signaling pathway.
Conclusions
Circ_0053943 may promote UM progression by stabilizing EGFR mRNA and activating the MAPK/ERK signaling pathway through forming a circ_0053943/IGF2BP3/EGFR RNA-protein ternary complex, which in turn provide a potential biomarker and therapeutic target for UM.
Improving Sustainable Tourism in Thanjavur – A Feasibility Study
Authors: M Sona 
Published: June 2022

Abstract
‘Tangible Cultural Heritage’ refers to physical artefacts produced, maintained and transmitted inter-generationally in a society. ‘Intangible Cultural Heritage’ indicates the practices, representations, expressions, knowledge, skills – as well as the instruments, objects, artefacts and cultural spaces associated therewith – that communities, groups and, in some cases, individuals recognize as part of their Cultural Heritage. Being the cradle to many of the arts and crafts in South India, Thanjavur is known for its arts like painting, bronze sculptures, and musical instruments. Manufacture of musical instruments like veena, tampura, violin, mrithangam, thavil and kanjira is another economic activity in the city. There are traces of the Marathi music form, Abhang, owing to the Maratha rule in the area. The study aims at preserving the culture of Thanjavur, by envisioning it as a living entity that interacts with its tourists for a wholesome experience. It focusses on design of a cultural experience centre that integrates the tangible and intangible elements of the cultural heritage of Thanjavur. It attempts to thrust on a sustainable tourism development, and improve the living standards of artisans, integrated with providing a multi-sensory experience of the Thanjavur culture to its tourists. The study includes both the tangible and intangible elements of the cultural heritage of Thanjavur. The most common fine arts and crafts in the context of Thanjavur have been chosen to set the cultural backdrop for the project. Contribution of performing arts is limited to the extent of provision for performance areas only, owing to the floating population of the respective artists. The study is limited to the district of Thanjavur.