bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uniform risk spectra for rocking structures
Authors: Reggiani Manzo Natalia , Lachanas Christos G. , Vassiliou Michalis F. , Vamvatsikos Dimitrios 
Published: June 2022

AbstractThis paper presents uniform risk spectra for zero stiffness bilinear elastic (ZSBE) systems. The ZSBE oscillator is a bilinear elastic system with zero post‐“yield” stiffness that satisfactorily predicts the response of different systems with negative lateral stiffness (e.g., free‐standing or restrained rocking blocks). It can be described by a single parameter; thus, it is simpler to produce its spectrum. Using the ZSBE proxy, this paper provides the uniform risk spectra for sites in six locations in Europe. The spectra are constructed using two distinct intensity measures (IMs): peak ground velocity (PGV) and peak ground acceleration (PGA). The efficiency of both IMs at different ranges of displacement demands is discussed and analytical approximations of the spectra are proposed.
Anticoagulant Rodenticide Contamination of Terrestrial Birds of Prey from Western Canada: Patterns and Trends, 1988–2018
Authors: Elliott John E. , Silverthorn Veronica , Hindmarch Sofi , Lee Sandi , Bowes Victoria , Redford Tony , Maisonneuve France 
Published: June 2022

Abstract
As the dominant means for control of pest rodent populations globally, anticoagulant rodenticides (ARs), particularly the second-generation compounds (SGARs), have widely contaminated nontarget organisms. We present data on hepatic residues of ARs in 741 raptorial birds found dead or brought into rehabilitation centers in British Columbia, Canada, over a 30-year period from 1988 to 2018. Exposure varied by species, by proximity to residential areas, and over time, with at least one SGAR residue detected in 74% of individuals and multiple residues in 50% of individuals. By comparison, we detected first-generation compounds in &lt;5% of the raptors. Highest rates of exposure were in barred owls (Strix varia), 96%, and great horned owls (Bubo virginianus), 81%, species with diverse diets, including rats (Rattus norvegicus and Rattus rattus), and inhabiting suburban and intensive agricultural habitats. Barn owls (Tyto alba), mainly a vole (Microtus) eater, had a lower incidence of exposure of 65%. Putatively, bird-eating raptors also had a relatively high incidence of exposure, with 75% of Cooper's hawks (Accipiter cooperii) and 60% of sharp-shinned hawks (Accipiter striatus) exposed. Concentrations of SGARs varied greatly, for example, in barred owls, the geometric mean ∑SGAR = 0.13, ranging from &lt;0.005 to 1.81 μg/g wet weight (n = 208). Barred owls had significantly higher ∑SGAR concentrations than all other species, driven by significantly higher bromadiolone concentrations, which was predicted by the proportion of residential land within their home ranges. Preliminary indications that risk mitigation measures implemented in 2013 are having an influence on exposure include a decrease in mean concentrations of brodifacoum and difethialone in barred and great horned owls and an increase in bromodialone around that inflection point. Environ Toxicol Chem 2022;41:1903–1917. © 2022 Her Majesty the Queen in Right of Canada. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. Reproduced with the permission of the Minister of Environment and Climate Change Canada.
Hand anthropometric dimensions and strengths in workers: A comparison of three occupations
Authors: Hajaghazadeh Mohammad , Taghizadeh Mohsen , Mohebbi Iraj , Khalkhali Hamidreza 
Published: June 2022

AbstractThe purpose of this study was to measure and compare the hand anthropometric dimensions and strengths of three different occupations. A cross‐sectional study was designed to measure 34 hand dimensions and 4 hand strengths of 558 participants consisted of office workers, vehicle mechanics, and farmers. A digital caliper, a hand dynamometer, and a pinch meter were used to collect data. Percentile values for each measurement were tabulated at the 5th, 50th, and 95th percentile levels. The analysis of variance, t test, and Cohen's d were performed to assess the differences in anthropometric variables between groups of workers. The findings demonstrated statistically significant differences in the mean size and strength of the hands across three occupations. Office workers' hands were significantly smaller than those of car mechanics and farmers, particularly in terms of hand depths and widths. Car mechanics' hand circumferences were bigger than those of farmers. Office workers produced the weakest hand strengths. Wrist breadth of workers showed the highest correlation with hand strengths. Compared to other studies, the hands of Iranian workers were wider and thicker, but the length of their hands was similar. Given the significant variances in hand anthropometry between occupational categories, these differences should be incorporated into the design and selection of hand‐related products such as gloves and hand tools for each group of workers.
Forecasting the incidence of dengue in Bangladesh—Application of time series model
Authors: Naher Shabnam , Rabbi Fazle , Hossain Md. Moyazzem , Banik Rajon , Pervez Sabbir , Boitchi Anika Bushra 
Published: June 2022

AbstractBackgroundDengue is an alarming public health concern in terms of its preventive and curative measures among people in Bangladesh; moreover, its sudden outbreak created a lot of suffering among people in 2018. Considering the greater burden of disease in larger epidemic years and the difficulty in understanding current and future needs, it is highly needed to address early warning systems to control epidemics from the earliest.ObjectiveThe study objective was to select the most appropriate model for dengue incidence and using the selected model, the authors forecast the future dengue outbreak in Bangladesh.Methods and MaterialsThis study considered a secondary data set of monthly dengue occurrences over the period of January 2008 to January 2020. Initially, the authors found the suitable model from Autoregressive Integrated Moving Average (ARIMA), Error, Trend, Seasonal (ETS) and Trigonometric seasonality, Box‐Cox transformation, ARMA errors, Trend and Seasonal (TBATS) models with the help of selected model selection criteria and finally employing the selected model make forecasting of dengue incidences in Bangladesh.ResultsAmong ARIMA, ETS, and TBATS models, the ARIMA model performs better than others. The Box‐Jenkin's procedure is applicable here and it is found that the best‐selected model to forecast the dengue outbreak in the context of Bangladesh is ARIMA (2,1,2).ConclusionBefore establishing a comprehensive plan for future combating strategies, it is vital to understand the future scenario of dengue occurrence. With this in mind, the authors aimed to select an appropriate model that might predict dengue fever outbreaks in Bangladesh. The findings revealed that dengue fever is expected to become more frequent in the future. The authors believe that the study findings will be helpful to take early initiatives to combat future dengue outbreaks.
The Kuwait Stitch: A novel surgical technique for surgical wound closures
Authors: Sartawi Muthana M. , Rahman Hafizur , Yousef Ibraheem , Kohlmann James M. 
Published: June 2022

AbstractThere are several stitch techniques used for surgical wound closing. Each stitch has its own benefits and drawbacks that a surgeon must balance before use. In this paper, we highlight some of the more common techniques utilized in operative wound closure and briefly discuss benefits and caveats one must be aware of before using. The rest of our paper will focus on a new technique, the Kuwait Stitch, with instructions on how to perform the technique followed by a discussion on the benefits and indications for use of this stitch.
The prevalence of cardiac and hepatic iron overload in patients with kidney failure: A protocol for systematic review and meta‐analysis
Authors: Nashwan Abdulqadir J. , Yassin Mohamed A. , Abd‐Alrazaq Alaa , Shuweihdi Farag , Abdul Rahim Hanan F. , Shraim Mujahed 
Published: June 2022

AbstractIntroductionFew studies have reported cardiac and hepatic iron overload in patients with kidney failure or end‐stage renal disease and the current evidence regarding the prevalence is still scarce. To the best of the authors' knowledge and following an exhaustive search; no systematic review/meta‐analysis has estimated the aggregated prevalence of cardiac and hepatic iron overload in this patient population.AimThis review aims to estimate the prevalence of hepatic and/or cardiac iron overload in patients with kidney failure who are receiving hemodialysis, peritoneal dialysis, or underwent kidney transplants.MethodsA systematic review with meta‐analysis will be conducted and reported in line with PRISMA guidelines. MEDLINE and Embase bibliographic databases will be searched using a comprehensive list of controlled vocabularies and keywords to identify relevant studies. All studies reporting the prevalence of hepatic and/or cardiac iron overload prevalence in patients with kidney failure will be considered. Risk of bias assessment for included studies will be conducted based on the study design. StataBE v17 and MetaXL v5.3 will be utilized to perform the meta‐analysis.DiscussionThe findings of this systematic review and analysis are expected to give information on the prevalence of iron overload among patients with kidney failure, which will optimize interventions and guide future research in this understudied field.
Early onset metastatic colorectal cancer in patients receiving panitumumab‐based upfront strategy: Overall and sex‐specific outcomes in the Valentino trial
Authors: Raimondi Alessandra , Randon Giovanni , Prisciandaro Michele , Pagani Filippo , Lonardi Sara , Antoniotti Carlotta , Bozzarelli Silvia , Sartore‐Bianchi Andrea , Tampellini Marco , Fanchini Laura , Murialdo Roberto , Clavarezza Matteo , Zaniboni Alberto , Berenato Rosa , Ratti Margherita , Petrelli Fausto , Antonuzzo Lorenzo , Giordano Monica , Rossi Alessandro , Di Bartolomeo Maria , Di Maio Massimo , Pietrantonio Filippo , Morano Federica 
Published: June 2022

AbstractAnti‐EGFRs plus doublet chemotherapy is considered the optimal upfront option for RAS/BRAF wild‐type left‐sided metastatic colorectal cancer (mCRC). Early‐onset (EO) mCRC has an increasing incidence and its prognostic/predictive role and management is debatable. We performed a post hoc analysis of Valentino study, that randomized RAS wild‐type mCRC patients to two panitumumab‐based maintenance regimens after FOLFOX/panitumumab induction. We assessed the safety and efficacy outcomes in patients stratified for age (<50/≥50 years old). We assessed progression‐free survival (PFS), overall survival (OS), response rate (ORR), rate of treatment‐related and panitumumab‐related adverse events (AEs) and quality of life (QoL). In 229 patients enrolled, 35 (15%) had EO mCRC, with a higher rate of female sex (P = .020) and lower rate of primary tumor resection (P = .001). Median PFS and OS were 10.9 vs 10.8 months (P = .593) and 28.1 vs 27.5 months (P = .865) in patients <50 and ≥50 years old, respectively, with no significant impact of maintenance arm. ORR and disease control rate were 74% vs 65% (P = .337) and 97% vs 81% (P = .013) in patients <50 or ≥50 years old. In younger patients, a trend for increased chemotherapy‐related AEs (peculiarly anemia) was shown, while significantly decreased EGFR‐related hypomagnesemia and increased skin rash were reported. No significant differences in treatment intensity or QoL were observed. In patients with EO mCRC and RAS wild‐type status, we found no differences in terms of survival outcomes based on age when selecting maintenance strategies. Management of treatment‐related AEs should consider the differential toxicity profile of age and sex.
3D bioprinting of gellan gum‐based hydrogels tethered with laminin‐derived peptides for improved cellular behavior
Authors: Alheib Omar , da Silva Lucilia P. , Youn Yun Hee , Kwon Il Keun , Reis Rui L. , Correlo Vitor M. 
Published: June 2022

AbstractThe treatment of skeletal muscle defects is still a topic of noteworthy concern since surgical intervention is not capable of recovering muscle function. Herein, we propose myoblasts laden in laminin‐inspired biofunctionalized gellan gum hydrogels as promising tissue‐engineered skeletal muscle surrogates. Gellan gum‐based hydrogels were developed by combining native gellan gum (GG) and GG tethered with laminin‐derived peptides (CIKVAVS (V), KNRLTIELEVRTC (T) or RKRLQVQLSIRTC (Q)), using different polymer content (0.75%–1.875%). Hydrogels were characterized in terms of compressive modulus, molecules trafficking, and C2C12 adhesion. Hydrogels with higher polymeric content (1.125%–1.875%) showed higher stiffness whereas hydrogels with lower polymer content (0.75%–1.125%) showed higher fluorescein isothiocyanate‐dextran molecules diffusion. Cell spreading was achieved regardless of the laminin‐derived peptide but preferred in hydrogels with higher polymer content (1.125%–1.875%). Taken together, hydrogels with 1.125% of polymer content were selected for printability analysis. GG‐based inks showed a non‐newtonian, shear‐thinning, and thixotropic behavior suitable for printing. Accordingly, all inks were printable, but inks tethered with T and Q peptides presented some signs of clogging. Cell viability was affected after printing but increased after 7 days of culture. After 7 days, cells were spreading but not showing significant signs of cell–cell communications. Therefore, cell density was increased, thus, myocytes loaded in V‐tethered GG‐based inks showed higher cell–cell communication, spreading morphology, and alignment 7, 14 days post‐printing. Overall, myoblasts laden in laminin‐inspired biofunctionalized GG‐based hydrogels are a promising skeletal muscle surrogate with the potential to be used as in vitro model or explored for further in vivo applications.
The lncARSR/PTEN/Akt/nuclear factor‐kappa B feedback regulatory loop contributes to doxorubicin resistance in hepatocellular carcinoma
Authors: Li Yaling , Li Jun , Chen Hongyan , Wang Jiting , Jiang Linhan , Tan Xiaoxia 
Published: June 2022

AbstractChemoresistance is a major obstacle to hepatocellular carcinoma (HCC) chemotherapy. Our previous study found that long noncoding RNA lncARSR (lncRNA Activated in RCC with Sunitinib Resistance) activated Akt signaling via repressing phosphatase and tensin homolog (PTEN) during doxorubicin resistance in HCC. The purpose of this study is to further explore lncARSR‐mediated mechanisms and roles during doxorubicin resistance in HCC. The expression of lncARSR was detected by real‐time quantitative polymerase chain reaction (qPCR). Nuclear factor‐kappa B (NF‐κB) activity was detected by NF‐κB luciferase reporter assays, western blot, and NF‐κB transcription factor assays. The effects of NF‐κB on lncARSR were detected by chromatin immunoprecipitation assay, promoter luciferase reporter assay, and real‐time qPCR. The effects of lncARSR/Akt/NF‐κB on doxorubicin resistance were detected by Cell Counting Kit‐8 assay, capsase‐3 activity assay, and terminal deoxynucleotidyl transferase‐mediated dUTP nick end labeling assay. lncARSR activated NF‐κB signaling through activation of Akt. NF‐κB transactivated lncARSR through directly binding lncARSR promoter and increasing lncARSR promoter activity. Akt transactivated lncARSR via activating NF‐κB signaling. Thus, lncARSR, Akt, and NF‐κB formed a positive feedback regulatory loop in HCC. Through this feedback loop, lncARSR auto‐regulated its transcription. Drug sensitivity assays showed that the lncARSR/Akt/NF‐κB feedback regulatory loop promoted doxorubicin resistance in HCC. These findings identified the lncARSR/Akt/NF‐κB feedback regulatory loop in HCC, which represent potential therapeutic targets for improving doxorubicin sensitivity in HCC.
Unbalanced ER‐mitochondrial calcium homeostasis promotes mitochondrial dysfunction and associated apoptotic pathways activation in methylmercury exposed rat cortical neurons
Authors: Pan Jingjing , Wei Yanfeng , Ni Linlin , Li Xiaoyang , Deng Yu , Xu Bin , Yang Tianyao , Sun Jingyi , Liu Wei 
Published: June 2022

AbstractMethylmercury (MeHg) is a cumulative environmental pollutant that can easily cross the blood–brain barrier and cause damage to the brain, mainly targeting the central nervous system. The purpose of this study is to investigate the role of calcium ion (Ca2+) homeostasis between the endoplasmic reticulum (ER) and mitochondria in MeHg‐induced neurotoxicity. Rat primary cortical neurons exposed to MeHg (0.25–1 μm) underwent dose‐dependent cell damage, accompanied by increased Ca2+release from the ER and elevated levels of free Ca2+in cytoplasm and mitochondria. MeHg also increased the protein and messenger RNA expressions of the inositol 1,4,5‐triphosphate receptor, ryanodine receptor 2, and mitochondrial calcium uniporter. Ca2+channel inhibitors 2‐aminoethyl diphenylborinate and procaine reduced the release of Ca2+from ER, while RR and 4,4′‐diisothiocyanatostilbene‐2,2′‐disulfonate inhibited Ca2+uptake from mitochondria. In addition, pretreatment with Ca2+chelator BAPTA‐AM effectively restored mitochondrial membrane potential levels, inhibited over opening of mitochondrial permeability transition pore, and maintained mitochondrial function stability. Meanwhile, the expression of mitochondrial apoptosis‐related proteins recovered to some extent, along with the reduction of the early apoptosis ratio. These results suggest that Ca2+homeostasis plays an essential role in mitochondrial damage and apoptosis induced by MeHg, which may be one of the important mechanisms of MeHg‐induced neurotoxicity.
Social connectedness, mindfulness, and coping as protective factors during the COVID‐19 pandemic
Authors: Dailey Stephanie F. , Parker Maggie M. , Campbell Andrew 
Published: June 2022

AbstractThe COVID‐19 pandemic has had an unprecedented psychological impact, revealing immense emotional disturbances among the general population. This study examined the extent to which social connectedness, dispositional mindfulness, and coping moderate symptoms of anxiety and depression in 1242 adults under the same government‐issued COVID‐19 stay‐at‐home mandate. Participants completed measures of anxiety, depression, dispositional mindfulness, social connectedness, and coping, and regression analyses were used to examine associations and interaction effects. Results indicated that social connectedness and dispositional mindfulness were associated with reduced symptoms. For individuals living with a partner, decreased mindfulness and avoidant coping were associated with anxious symptoms. In households with children, overutilization of approach coping served to increase symptoms of depression. Results indicate the importance of considering social connectedness, mindfulness, and coping in counseling to enhance factors serving to protect clients during a public health crisis. Implications for professional counselors and areas of future research are discussed.
Are empathy profiles and perceived social support associated with depressive and grief‐related symptoms in suicide survivors?
Authors: Toffol Elena , Aliverti Emanuele , Idotta Carlo , Capizzi Giovanna , Scocco Paolo ,   SOPROXI Team
Published: June 2022

AbstractObjectiveTo investigate the link between empathy, perceived social support, and depressive and grieving symptoms in suicide survivors.MethodsScores on the Beck Depression Inventory (BDI), Inventory of Complicated Grief (ICG), Prolonged Grief Disorder (PGD), Interpersonal Reactivity Index (IRI), and the Social Support section of the Interpersonal Questionnaire were collected from 265 survivors. Relations were tested via multivariate regression models.ResultsLower Perspective Taking (PT) was related with higher levels of BDI score, and higher Personal Distress (PD) was associated with higher BDI, ICG, and PGD scores. Higher levels of Social Support were related with higher BDI and ICG (but not PGD) scores.ConclusionEmpathic PD and PT, and perceived social support are differently associated with depression and grief‐related symptoms. Empathy‐focused psychotherapies and empowerment of social support may reduce symptoms in suicide survivors.
Kinetics of phosphorus sorption/desorption by soil aggregates in a long‐term revegetation desert ecosystem
Authors: Li Chengyi , He Mingzhu , Ren Jianxin , Li Manfei , Tang Liang 
Published: June 2022

AbstractElucidating the kinetics of phosphorus (P) sorption and desorption in soil aggregates of different sizes has important implications for the regulation of plant growth and development in revegetation desert ecosystems. In this study, the Freundlich models were used to describe the kinetics of P sorption and desorption by soil aggregates of five sizes (0.5–0.25, 0.25–0.15, 0.15–0.10, 0.10–0.05 and <0.05 mm) in a long‐term revegetation desert ecosystem. The results showed that long‐term (>65 years) revegetation significantly improved the properties of desert soil in terms of P fractions (p < 0.05), soil bulk density (p < 0.05), and soil type. The Freundlich models well‐described P sorption and desorption by soil aggregates in the revegetated desert. Soil aggregates of 0.25–0.15 mm adsorbed the lowest amount of P (P adsorbed: KF = 0.26, n = 0.97) but desorbed the highest amount of P (P desorbed: KF = 2.41, n = −0.97). Soil aggregates of <0.05 mm adsorbed the most P (P adsorbed: KF = 0.60, n = 0.85) but desorbed the lowest P (P desorbed: KF = 1.67, n = −1.00). Furthermore, P sorption was fastest when the added P was 0–1.0 mg L−1, and P desorption was fastest at 1–3 hr. Soil aggregates that were 0.25–0.15 mm in size had the highest mass proportion in the long‐term revegetation desert and played a key role in supporting available P for plant development. Soil aggregates of <0.05 mm adsorbed the most P; however, their contribution was constrained because they had the smallest mass proportion and the lowest amount of P desorption.
Conversion of rainforest to rubber plantations impacts the rhizosphere soil mycobiome and alters soil biological activity
Authors: Monkai Jutamart , Purahong Witoon , Nawaz Ali , Wubet Tesfaye , Hyde Kevin D. , Goldberg Stefanie D. , Mortimer Peter E. , Xu Jianchu , Harrison Rhett D. 
Published: June 2022

AbstractIn Southeast Asia and Asia, large swathes of rainforest have been converted to rubber plantations, with major consequences for biodiversity and ecosystem services. However, the impact of this land use conversion on rhizosphere soil mycobiome has not yet been addressed. This study aimed to investigate how rhizosphere soil fungal communities and their associated biological activity (soil respiration, soil methane (CH4), and potential soil enzyme production) are impacted by the conversion of rainforest to rubber plantations. Fungal richness and community composition in rhizosphere soils collected from natural rainforests, immature rubber, and mature rubber plantations were analyzed using paired‐end Illumina sequencing. The conversion of natural rainforest to rubber plantations significantly altered fungal community composition of specific functional groups (saprotrophs, pathogens, and mycorrhiza). We observed significant loss of saprotrophic and ectomycorrhizal fungi in natural rainforests, but enrichment of plant pathogenic fungi in immature rubber plantations. The mechanism underlying the effects of forest conversion on changes in fungal communities is related to reductions in soil pH, total nitrogen (N), and ammonium (NH4) in rubber plantations. Conversion to rubber plantation also resulted in decline of soil respiration rates and less potential for cellulase and chitinase productions. The significant negative correlations between fungal richness and soil respiration in mature rubber plantations indicated high competition among fungi and low nutrient availability in this system. We demonstrate the negative consequences of the conversion of rainforest to rubber plantations on soil biological activity and significant changes in fungal community composition that could threaten long‐term ecosystem functions.