bluuebunny/crossref_metadata_2025_split huggingface dataset:
COOPERATING THROUGH THE GENERAL ASSEMBLY TO END SERIOUS BREACHES OF PEREMPTORY NORMS
Authors: Barber Rebecca J 
Published: January 2022

AbstractThe International Law Commission's 2019 Draft Conclusions on Peremptory Norms of International Law assert that States have an obligation to cooperate to end serious breaches of peremptory norms. International law provides scarce guidance, however, regarding how States are expected to fulfil that obligation. This article seeks to elaborate: first, whether the prohibition of crimes against humanity and the ‘basic rules’ of international humanitarian law are peremptory norms; second, what States are required to do to fulfil their obligation to cooperate; and third, how States might utilise the General Assembly as a forum through which to fulfil that obligation.
Cross-language activation in bimodal bilinguals: Do mouthings affect the co-activation of speech during sign recognition?
Authors: Ormel Ellen , Giezen Marcel R. , Van Hell Janet G. 
Published: January 2022

AbstractThe present study provides insight into cross-language activation in hearing bimodal bilinguals by (1) examining co-activation of spoken words during processing of signs by hearing bimodal bilingual users of Dutch (their L1) and Sign Language of the Netherlands (NGT; late learners) and (2) investigating the contribution of mouthings to bimodal cross-language activation. NGT signs were presented with or without mouthings in two sign-picture verification experiments. In both experiments the phonological relation (unrelated, cohort overlap or final rhyme overlap) between the Dutch translation equivalents of the NGT signs and pictures was manipulated. Across both experiments, the results showed slower responses for sign-picture pairs with final rhyme overlap relative to phonologically unrelated sign-picture pairs, indicating co-activation of the spoken language during sign processing, but no significant effect for sign-picture pairs with cohort overlap in Dutch. In addition, co-activation was not affected by the presence or absence of mouthings.
A Statistical Examination of EMIC Wave‐Driven Electron Pitch Angle Scattering Signatures
Authors: Adair L. , Angelopoulos V. , Sibeck D. , Zhang X.‐J. 
Published: January 2022

AbstractElectromagnetic ion cyclotron (EMIC) waves have long been thought to contribute significantly to the variability of Earth's outer radiation belt because of their ability to scatter relativistic (>0.5 MeV) electrons into the loss cone on short timescales. We investigate statistically such pitch angle scattering signatures (“bite‐outs”) and their quantitative agreement with cold plasma theory. Our analysis is based on EMIC wave events and local plasma parameters observed simultaneously with energetic electrons by the Van Allen Probes between February and May 2017. We determine the energy and pitch angle ranges in which relativistic electron scattering is likely and find that, on average, EMIC wave‐driven scattering of core (E ≤ 2 MeV) electrons is possible in 28% of events. By comparing the expected ranges for scattering to electron flux measurements co‐located with the wave activity, we determine that scattering signatures are found in 46% of those. Additionally, we find that the scattering signatures are more likely to occur under increased geomagnetic activity and for waves with greater wave power. These results provide observational evidence that EMIC wave‐driven scattering of core relativistic electrons is common in the duskside outer radiation belt.
Surface Displacement and Source Model Separation of the Two Strongest Earthquakes During the 2019 Ridgecrest Sequence: Insights From InSAR, GPS, and Optical Data
Authors: He Lijia , Feng Guangcai , Hu Jun , Xu Wenbin , Liu Jihong , Li Zhiwei , Feng Zhixiong , Wang Yuedong , Lu Hao 
Published: January 2022

AbstractSince the occurrence of the 2019 Mw 6.4 and Mw 7.1 Ridgecrest earthquake sequence in the Eastern California Shear Zone, coseismic deformation following the two earthquakes has been intensively studied, and source modeling with interferometric synthetic aperture radar (InSAR), Global Positioning System (GPS) and seismological datasets has been favored. However, we recently found that the coseismic modeling of the two earthquakes constrained by the dense near‐field Planet‐Lab optical measurements can be more detailed than the previously estimated, which requires an accurate Planet‐Lab displacement. In this study, we improve the long wavelength orbital ramps correction method for obtaining a more accurate Planet‐Lab horizontal displacement field. The corrected dense near‐field Planet‐Lab data are firstly used together with the intermediate‐field GPS data to invert and distinguish the fault slip distribution for the two earthquakes. The same scheme is used to simultaneously invert the InSAR, SAR, GPS, and optical datasets, to improve the constraints on seismic source parameters. Our inversion results show that the joint‐event slip model is rougher than the two single‐event slip models, but it has a more concentrated slip pattern and larger slip amplitude in some zones. We show that adding a near‐field constraint of the Planet‐Lab data in the combined‐data inversion can reduce the slip parameter uncertainty and enhance the model resolution. The Coulomb failure stress changes on the southeastern Blackwater, the southern Owens Valley, and the central Panamint Valley faults are enhanced by about 0.4–0.8 bar by the 2019 Ridgecrest earthquake sequence.
Scaling Law for Boundary Layer Inner Eyewall Pumping in Concentric Eyewalls
Authors: Kuo Hung‐Chi , Tsujino Satoki , Hsu Tien‐Yiao , Peng Melinda S. , Su Shih‐Hao 
Published: January 2022

AbstractThis study explains why observed storms with long concentric eyewall (CE) duration often have a large moat size. A series of slab boundary layer model experiments are conducted with the free atmosphere forcing from different CE structures. The experimental results indicate that the inner eyewall pumping (IEP), the maximum vertical motion at the inner eyewall region, increases with the increase in moat size d and vortex maximum wind vm, the decrease in the inner eyewall radius rm, and increase in inner eyewall vorticity. A scaling law is derived from hundreds of SBL experiments with four variables: IEP win, vortex inner radius rm, vortex maximum wind vm, and moat size d. The dimensionless scaling law is where w∗ = win/vm, d∗ = ζd/c, ζ is the vorticity 2vm/rm, and c is a constant gravity wave speed. The moat size divided by the Rossby length c/ζ, the dimensionless moat size d∗, combines the effect of the moat size and the vortex pressure gradient force to accelerate the inflow and to enlarge the IEP for inner eyewall convection maintenance. A phase diagram of IEP with vortex structure dimensionless moat ζd/c and vortex intensity vm is constructed based on the scaling law for the aircraft and satellite observations. The eyewall replacement cycle may be viewed as the process to reduce the IEP from the decrease of the vortex intensity and the vortex size of the dimensionless moat. This leads to the ultimate disappearance of the inner eyewall.
Chronic lymphocytic leukemia (CLL) with Reed–Sternberg-like cells vs Classic Hodgkin lymphoma transformation of CLL: does this distinction matter?
Authors: King Rebecca L. , Gupta Alia , Kurtin Paul J. , Ding Wei , Call Timothy G. , Rabe Kari G. , Kenderian Saad S. , Leis Jose F. , Wang Yucai , Schwager Susan M. , Slager Susan L. , Kay Neil. E. , Koehler Amber , Ansell Stephen M. , Inwards David J. , Habermann Thomas M. , Shi Min , Hanson Curtis A. , Howard Matthew T. , Parikh Sameer A. 
Published: January 2022

AbstractThe distinction between chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with isolated Hodgkin/Reed–Sternberg cells (CLL-HRS; background milieu with a paucity of inflammatory cells) and overt transformation to classic Hodgkin lymphoma (CLL-HL; mixed inflammatory background) is incompletely understood. This retrospective study examined the clinicopathologic features of CLL-HRS (n = 15) and CLL-HL (n = 31) patients seen over the past three decades from a single institution. The phenotypic features of Reed–Sternberg cells in both groups were similar, including expression of CD30, CD15, and PAX5, as well as EBV status. However, a spectrum of background CLL/SLL infiltration amongst the HRS cells was noted on pathologic review, and four patients had both diagnoses, either concurrently or in succession. The median overall survival (OS) of patients with CLL-HRS was 17.5 months compared to 33.5 months for patients with CLL-HL (P = 0.24). Among patients with CLL-HRS, those who received Hodgkin-directed therapy had a significantly longer median OS (57 months) compared to those who received CLL-directed therapy (8.4 months, P = 0.02). Our clinical and pathologic findings suggest a biologic continuum between CLL-HRS and CLL-HL and indicate that CLL-HRS patients may benefit from Hodgkin-directed therapy.
Tumor-associated macrophages promote cholangiocarcinoma progression via exosomal Circ_0020256
Authors: Chen Shaoyi , Chen Zuxiao , Li Zongyan , Li Shiying , Wen Zilong , Cao Liangqi , Chen Yubin , Xue Ping , Li Haiyan , Zhang Dawei 
Published: January 2022

AbstractThis study investigated the exosomal circular RNAs (CircRNAs) produced by tumor-associated macrophages and delivered into the microenvironment of cholangiocarcinoma cells in order to use them as molecular targets for clinical therapy. Tumor-associated M2 macrophages (TAMs) were induced from THP-1 cells and identified by flow cytometry. The TAM-secreted exosomes were isolated from conditioned medium and a CircRNA microarray assay was performed to identify CircRNAs that were uniquely expressed in the isolated exosomes. Circ_0020256 was especially identified based on having the highest differential expression level among all of the CircRNA candidates. In vitro and in vivo experiments were performed to assess the effects of TAMs, exosomes, and Circ_0020256 on the growth and migration of cholangiocarcinoma (CCA) cells. The induced TAMs promoted the proliferation, migration, and invasion of CCA cells and those effects were mediated by exosomes secreted by the TAMs. In CCA cells (RBE and HCCC-9810), Circ_0020256 significantly promoted cellular activity by interacting with its intra-cellular microRNA target, miR-432-5p. In contrast, overexpression of transcription factor E2F3 in CCA cells restored the CCA cellular activities that were inhibited by miR-432-5p. On the other hand, treatment with small interference RNA (siRNA) for Circ_0020256 inhibited CCA cell proliferation, migration, and invasion both in vitro and in vivo. In conclusion, Circ_0020256 in TAM-secreted exosomes promoted the proliferation, migration, and invasion of CCA cells, and that promotional activity was regulated via a Circ_0020256/miR-432-5p/E2F3 axis.
Charge density waves and Fermi surface reconstruction in the clean overdoped cuprate superconductor Tl2Ba2CuO6+δ
Authors: Tam C. C. , Zhu M. , Ayres J. , Kummer K. , Yakhou-Harris F. , Cooper J. R. , Carrington A. , Hayden S. M. 
Published: January 2022

AbstractHall effect and quantum oscillation measurements on high temperature cuprate superconductors show that underdoped compositions have small Fermi surface pockets whereas when heavily overdoped, a single much larger pocket is found. The origin of this change in electronic structure has been unclear, but may be related to the high temperature superconductivity. Here we show that the clean overdoped single-layer cuprate Tl2Ba2CuO6+δ (Tl2201) displays CDW order with a remarkably long correlation length ξ ≈ 200 Å which disappears above a hole doping of pCDW ≈ 0.265. We show that the evolution of the electronic properties of Tl2201 as the doping is lowered may be explained by a Fermi surface reconstruction which accompanies the emergence of the CDW below pCDW. Our results demonstrate importance of CDW correlations in understanding the electronic properties of overdoped cuprates.
Age as a moderator of the relationship between planning and temporal information processing
Authors: Jablonska Katarzyna , Stanczyk Magdalena , Piotrowska Magdalena , Szymaszek Aneta , Lukomska Barbara , Bednarek Hanna , Szelag Elzbieta 
Published: January 2022

AbstractPlanning is a fundamental mental ability related to executive functions. It allows to select, order and execute subgoals to achieve a goal. Studies have indicated that these processes are characterised by a specific temporal dynamics reflected in temporal information processing (TIP) in some tens of millisecond domain. Both planning and TIP decline with age but the underlying mechanisms are unclear. The novel value of the present study was to examine these mechanisms in young (n = 110) and elderly (n = 91) participants in Tower of London task, considering two structural properties of problems: search depth related to static maintenance in working memory, and goal ambiguity reflecting dynamic cognitive flexibility. Results revealed that TIP predicted planning accuracy both directly and indirectly (via preplanning) but only in young participants in problems characterised by high goal ambiguity. Better planning is related to longer preplanning and more efficient TIP. This result demonstrates for the first time age-related differences in the contribution of TIP to planning. In young participants TIP contributed to dynamic cognitive flexibility, but not to static maintenance processes. In elderly such relation was not observed probably because the deficient planning might depend on working memory maintenance rather than on cognitive flexibility.
Whole-genome single nucleotide variant phylogenetic analysis of Mycobacterium tuberculosis Lineage 1 in endemic regions of Asia and Africa
Authors: Netikul Thidarat , Thawornwattana Yuttapong , Mahasirimongkol Surakameth , Yanai Hideki , Maung Htet Myat Win , Chongsuvivatwong Virasakdi , Palittapongarnpim Prasit 
Published: January 2022

AbstractMycobacterium tuberculosis (Mtb) lineage 1 (L1) contributes considerably to the disease morbidity. While whole genome sequencing (WGS) is increasingly used for studying Mtb, our understanding of genetic diversity of L1 remains limited. Using phylogenetic analysis of WGS data from endemic range in Asia and Africa, we provide an improved genotyping scheme for L1. Mapping deletion patterns of the 68 direct variable repeats (DVRs) in the CRISPR region of the genome onto the phylogeny provided supporting evidence that the CRISPR region evolves primarily by deletion, and hinted at a possible Southeast Asian origin of L1. Both phylogeny and DVR patterns clarified some relationships between different spoligotypes, and highlighted the limited resolution of spoligotyping. We identified a diverse repertoire of drug resistance mutations. Altogether, this study demonstrates the usefulness of WGS data for understanding the genetic diversity of L1, with implications for public health surveillance and TB control. It also highlights the need for more WGS studies in high-burden but underexplored regions.
Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder
Authors: Seok Jin Myoung , Cho Wanzee , Son Doo-Hwan , Shin Jong Hwa , Cho Eun Bin , Kim Sung Tae , Kim Byoung Joon , Seong Joon-Kyung , Min Ju-Hong 
Published: January 2022

AbstractAlthough fatigue is a major symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), the underlying mechanism remains unclear. We explored the relationship between subcortical structures and fatigue severity to identify neural substrates of fatigue in NMOSD. Clinical characteristics with brain magnetic resonance imaging were evaluated in forty patients with NMOSD. Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-fatigue) questionnaire (a higher score indicates less fatigue). We assessed the correlation between subcortical structures and fatigue severity using surface-based shape analysis. Most of the enrolled patients showed fatigue (72.5%; mean FACIT-fatigue score, 34.8 ± 10.8). The FACIT-fatigue score was negatively correlated with Expanded Disability Status Scale and Beck Depression Inventory scores (r = − 0.382, p = 0.016; r = − 0.578, p < 0.001). We observed that the right thalamus was the only extracted region for various threshold experiments. Further, patients with lower FACIT-fatigue scores (more fatigue) had decreased local shape volume in the right thalamus. Fatigue is common in patients with NMOSD, and atrophy in the right thalamus is strongly correlated with fatigue severity. The local shape volume of the right thalamus might serve as a biomarker of fatigue in NMOSD.
Banana stem and leaf biochar as an effective adsorbent for cadmium and lead in aqueous solution
Authors: Liu Xiyang , Li Gaoxiang , Chen Chengyu , Zhang Xiaorui , Zhou Kuan , Long Xinxian 
Published: January 2022

AbstractLead (Pb) and cadmium (Cd) are toxic heavy metals commonly found in aqueous environments. Biochar as a green adsorbent generated from biomass feedstock may be used for effective removal of these heavy metals. This study investigated the adsorption kinetics and isotherms of Pb2+ and Cd2+ in aqueous solutions at different pH by biochar prepared from banana stem and leaf (BSL-BC) at 400 °C. Characterizations using scanning electron microscope, X-ray diffraction, and Fourier-transform infrared spectroscopy showed that the synthesized BSL-BC had rough surface, porous structure, and oxygen-containing functional groups. The adsorption of Pb2+ and Cd2+ onto BSL-BC reached equilibrium in 8 h and 200 min, respectively, with faster adsorption attained at higher pH and the optimum pH occurred at 5 (Pb2+) and 8 (Cd2+). All adsorption kinetic data followed the pseudo-second-order rate model. The adsorption isotherm data of Pb2+ and Cd2+ could be well-described by the Langmuir and Freundlich models, respectively, whereas neither the Temkin or Dubinin–Radushkevich models provided satisfactory fitting results. The maximum adsorption capacities for Pb2+ and Cd2+ were 302.20 and 32.03 mg/g, respectively. The calculated mechanism contributions showed that complexation with oxygen-containing functional groups, ion exchange, mineral precipitation, and Pb2+/Cd2+-π coordination accounted for 0.1%, 8.4%, 88.8%, and 2.6% to Pb2+ adsorption, and 0.4%, 6.3%, 83.0%, and 10.4% to Cd2+ adsorption, respectively. Therefore, mineral precipitation was likely the major mechanism responsible for adsorption of both Pb2+ and Cd2+ by BSL-BC. The results suggest that the synthesized BSL-BC has great potential for adsorption of Pb2+ and Cd2+ from aqueous solutions.
Syntax errors do not disrupt acoustic communication in the common cuckoo
Authors: Moskát Csaba , Hauber Márk E. 
Published: January 2022

AbstractWhen acoustic communication signals are distorted, receivers may misunderstand the signal, rendering it ineffective. Common cuckoos (Cuculus canorus) are popularly known for the males’ simple, two-note advertisement calls, the “cu-coo” used for declaring the male’s breeding territories. Cuckoos do not learn their calls (vocal non-learners), so they are expected to have a limited ability to produce different acoustic signals. Nevertheless, male cuckoos appear to make syntax errors (e.g., repeated, reversed, or fragmented elements) even in their simple advertisement calls. We conducted a playback experiment with male cuckoos, broadcasting ten call types, including seven modified calls with errors (e.g. “cu-cu”, and “coo-cu”) and three natural calls used for comparisons (“cu-coo”, “cu-cu-coo”, and interspecific control). Male cuckoos responded in a manner suggesting that the presence of the first (“cu”) note of the natural 2-note “cu-coo” call in any form or combination yield effective signals. However, through the elevated frequency (by about 200 Hz) and greater speed of the “cu” note, the natural 3-note version “cu-cu-coo” call appears to have gained a novel communicative function in signalling with female cuckoos. Thus, syntax errors in calls with the “cu” element are not responsible for changing the function of the male cuckoos’ “cu-coo” call.
Formation of Co–O bonds and reversal of thermal annealing effects induced by X-ray irradiation in (Y, Co)-codoped CeO2 nanocrystals
Authors: Wu Tai-Sing , Chen Sheng-Fu , Weng Shih-Chang , Soo Yun-Liang 
Published: January 2022

AbstractWe report an unconventional effect of synchrotron X-ray irradiation in which Co–O bonds in thermally annealed (Y, Co)-codoped CeO2 nanocrystal samples were formed due to, instead of broken by, X-ray irradiation. Our experimental data indicate that escaping oxygen atoms from X-ray-broken Ce–O bonds may be captured by Co dopant atoms to form additional Co–O bonds. Consequently, the Co dopant atoms were pumped by X-rays from the energetically-favored thermally-stable Co-O4 square-planar structure to the metastable octahedral Co-O6 environment, practically a reversal of thermal annealing effects in (Y, Co)-codoped CeO2 nanocrystals. The band gap of doped CeO2 with Co dopant in the Co-O6 structure was previously found to be 1.61 eV higher than that with Co in the Co-O4 environment. Therefore, X-ray irradiation can work with thermal annealing in opposing directions to fine tune and optimize the band gap of the material for specific technological applications.
Highly Stereoselective Formation of a Spiro Center by a 1,4-Addition/Elimination Reaction of 3,5-Difluorocyclohexa-2,5-dienones
Authors: Morita Masao , Kurouchi Hiroaki , Nemoto Nobuaki 
Published: January 2022

AbstractSpirocyclic 3,5-difluorocyclohexa-2,5-dienones possessing a triisopropylsiloxy-containing cyclic ether appendage were synthesized by oxidative dearomatization of the corresponding phenols. By group selectivity in the nucleophilic 1,4-addition/elimination reaction, highly stereoselective formation of the spiro center was successfully achieved. This reaction might provide access to total syntheses of (+)-bisdechlorogeodin and (+)-geodin with complete control of the formation of the spirocyclic structure.
Defining Clinical and Microbiological Nonresponse in Ventilator-Associated Pneumonia
Authors: Ceccato Adrian , Torres Antoni 
Published: January 2022

AbstractVentilator-associated pneumonia (VAP) is a severe complication of mechanical ventilation, with mortality reduced most effectively by adequate early antibiotic treatment. The clinical and microbiologic response can be assessed easily from 72 hours after starting antibiotic treatment. Evidence of nonresponse is based on several factors: (1) lack of clinical improvement, (2) radiographic progression, (3) an impaired Sequential Organ Failure Assessment (SOFA) score, (4) no improvement by days 3 to 5 on the Clinical Pulmonary Infection Score (CPIS), (5) no decreased in biomarkers on day 3, and (6) isolation of a new pathogen on day 3. Among the clinical markers of treatment failure, physicians should consider no improvement in the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2), persistence of fever or hypothermia, persistence of purulent respiratory secretions, and new-onset septic shock or multiple-organ dysfunction syndrome. Microbiological isolation of a new pathogen on day 3 is also associated with higher mortality, but persistence of the original pathogen does not seem to be associated with a worse prognosis. The real impact of changes to treatment after diagnosing nonresponsive VAP is unknown. Physicians must evaluate whether treatments are adequate in terms of sensitivity, dose, and route. Pharmacokinetically and pharmacodynamically optimized doses are recommended in these patients. Clinical stabilization of comorbidities or underlying conditions may be of benefit.