bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coping with adverse childhood experiences during the COVID-19 pandemic: Perceptions of mental health service providers
Authors: Choudhury Sumaita , Yeh Paul G. , Markham Christine M. 
Published: September 2022

BackgroundAdverse Childhood Experiences (ACEs) have been associated with long-term physical and mental health conditions, toxic stress levels, developing unstable interpersonal relationships, and substance use disorders due to unresolved childhood adversities.AimsThis study assessed the perspectives of mental health providers (MHPs) regarding their adult patients’ coping with ACEs during COVID-19 in Houston, Texas. Specifically, we explored how individuals with ACEs are coping with the increased stresses of the pandemic, how MHPs may provide therapeutic support for individuals with ACEs during this pandemic, pandemic-related challenges of accessing and utilizing mental health services for individuals with ACEs, and the awareness and treatment of ACEs among MHPs.MethodsTen in-depth semi-structured virtual interviews were conducted with licensed MHPs from November 2021 to April 2022 in Houston, Texas. Interviews were coded and analyzed for emerging themes through an inductive open coding approach to discover insights regarding coping with ACEs during COVID-19.ResultsFour key themes experienced by individuals with ACEs emerged from the MHP interviews: (1) Maladaptive emotional dissonance and coping outlets during the pandemic, (2) Difficulties with social connectedness and significance of social support, (3) Heightened daily life stressors and coping with the ongoing disruption of the pandemic, and (4) Changing interactions with the mental health system. Themes from this study highlighted that resilience, seeking treatment, and strong social support can help develop healthy coping strategies among individuals with ACEs.ConclusionThis study may help inform best clinical practices to develop interventions and policies regarding ACEs such as a resilience-promotion approach that targets all the socio-ecological levels. In addition, findings highlight the synergy of psychotherapeutic and pharmacological management via tele-health modalities, in helping individuals with ACEs continue receiving the care they deserve and need during a persistent pandemic and an uncertain future.
Differential trajectories of tobacco smoking in people at ultra-high risk for psychosis: Associations with clinical outcomes
Authors: Schirmbeck Frederike , van der Ven Els , Boyette Lindy-Lou , McGuire Philip , Valmaggia Lucia R. , Kempton Matthew J. , van der Gaag Mark , Riecher-Rössler Anita , Barrantes-Vidal Neus , Nelson Barnaby , Krebs Marie-Odile , Ruhrmann Stephan , Sachs Gabriele , Rutten Bart P. F. , Nordentoft Merete ,   EU-GEI High Risk Study Group, de Haan Lieuwe , Vermeulen Jentien M. 
Published: September 2022

ObjectivePeople at ultra-high risk (UHR) for psychosis have a high prevalence of tobacco smoking, and rates are even higher among the subgroup that later develop a psychotic disorder. However, the longitudinal relationship between the course of tobacco smoking and clinical outcomes in UHR subjects is unknown.MethodsWe investigated associations between tobacco smoking and clinical outcomes in a prospective study of UHR individuals (n = 324). Latent class mixed model analyses were used to identify trajectories of smoking severity. Mixed effects models were applied to investigate associations between smoking trajectory class and the course of attenuated psychotic symptoms (APS) and affective symptoms, as assessed using the CAARMS.ResultsWe identified four different classes of smoking trajectory: (i) Persistently High (n = 110), (ii) Decreasing (n = 29), (iii) Persistently Low (n = 165) and (iv) Increasing (n = 20). At two-year follow-up, there had been a greater increase in APS in the Persistently High class than for both the Persistently Low (ES = 9.77, SE = 4.87, p = 0.046) and Decreasing (ES = 18.18, SE = 7.61, p = 0.018) classes. There were no differences between smoking classes in the incidence of psychosis. There was a greater reduction in the severity of emotional disturbance and general symptoms in the Decreasing class than in the High (ES = −10.40, SE = 3.41, p = 0.003; ES = −22.36, SE = 10.07, p = 0.027), Increasing (ES = −11.35, SE = 4.55, p = 0.014; ES = −25.58, SE = 13.17, p = 0.050) and Low (ES = −11.38, SE = 3.29, p = 0.001; ES = −27.55, SE = 9.78, p = 0.005) classes, respectively.ConclusionsThese findings suggests that in UHR subjects persistent tobacco smoking is associated with an unfavorable course of psychotic symptoms, whereas decrease in the number of cigarettes smoked is associated with improvement in affective symptoms. Future research into smoking cessation interventions in the early stages of psychoses is required to shine light on the potential of modifying smoking behavior and its relation to clinical outcomes.
Factors influencing resilience of parents with children with neurodevelopmental disorders: The role of structural language, social cognition, and social support
Authors: Flores-Buils Raquel , Andrés-Roqueta Clara 
Published: September 2022

BackgroundResilience allows a more positive coping and improves parents' wellbeing when they face a difficult situation like having a child with a neurodevelopmental disorder (NDD). We aim to analyze the development of resilience in parents of children with different NDD (ASD, DLD and ADHD) with different levels of structural language and social cognition, as well as the social support available for their families, and compare it to children with typical development (TD).MethodWe analyzed the level of resilience of 156 parents, 73 with children with TD and 73 with three different NDD, taking into account variables such as age, structural language (receptive grammar) and social cognition (emotional understanding) of the children, and also the type of social support available to them.ResultsChildren with DLD and ASD showed lower receptive grammar and emotional comprehension skills, although only parents of children with ASD obtained better resilience scores. Moreover, age of children and formal support variables predicted the resilience of the parents according to the type of NDD.DiscussionThe severity of social cognition and structural language difficulties of children with NDD and the fact of having support from professionals and family associations have a significant influence on the development of parental resilience.
Bipolar disorders and retinal electrophysiological markers (BiMAR): Study protocol for a comparison of electroretinogram measurements between subjects with bipolar disorder and a healthy control group
Authors: Gross Grégory , Tursini Katelyne , Albuisson Eliane , Angioi-Duprez Karine , Conart Jean-Baptiste , Louis Dorr Valérie , Schwan Raymund , Schwitzer Thomas 
Published: September 2022

BackgroundBipolar disorders (BD) is a common, chronic and disabling psychiatric condition. In addition to being characterized by significant clinical heterogeneity, notable disturbances of sleep and cognitive function are frequently observed in all phases of the disease. Currently, there is no readily available biomarker in current clinical practice to help diagnose or predict the disease course. Thus, identification of biomarkers in BD is today a major challenge. In this context, the study of electrophysiological biomarkers based on electroretinogram (ERG) measurements in BD seems highly promising. The BiMAR study aims to compare electrophysiological data measured with ERG between a group of euthymic patients with BD and a group of healthy control subjects. Secondarily, we will also describe the existing potential relationship between clinical, sleep and neuropsychological phenotypes of patients and electrophysiological data.MethodsThe BiMAR study is a comparative and monocentric study carried out at the Expert Center for BD in Nancy, France. In total, 70 euthymic adult patients with BD and 70 healthy control subjects will be recruited. Electrophysiological recordings with ERG and electroencephalogram (EEG) will be performed with a virtual reality headset after a standardized clinical evaluation to all participants. Then, an actigraphic monitoring of 21 consecutive days will be carried out. At the end of this period a neuropsychological evaluation will be performed during a second visit. The primary outcome will be electrophysiological measurements with ERG flash and pattern. Secondary outcomes will be EEG data, sleep settings, clinical and neuropsychological assessments. For patients only, a complementary ancillary study, carried out at the University Hospital of Nancy, will be proposed to assess the retinal structure and microvascularization using Optical Coherence Tomography. Recruitment started in January 2022 and will continue until the end of July 2023.DiscussionThe BiMAR study will contribute to identifying candidate ERG electrophysiological markers for helping the diagnosis of BD and identify subgroups of patients with different clinical profiles. Eventually, this would allow earlier diagnosis and personalized therapeutic interventions.Clinical trial registrationThe study is registered at Clinicaltrials.gov, NCT05161546, on 17 December 2021 (https://clinicaltrials.gov/ct2/show/NCT05161546).
Trends in anti-HER2 drugs consumption and influencing factors
Authors: Liu Jie , Zhang Xiaolei , Wang Biao , Dai Huizhen , Dou Dahai , Fang Wentong 
Published: September 2022

BackgroundHuman epidermal growth factor receptor 2 (HER2) inhibitors have been approved to treat various cancers with HER2 amplification. The Chinese government has made great efforts to improve the availability and affordability of these drugs. This study aimed to analyze the trends in anti-HER2 drug consumptions in Nanjing from 2012 to 2021, and explore influencing factors.MethodsData about use of anti-HER2 drugs in 2012–2021 were extracted from Jiangsu Medicine Information Institute. Six types of anti-HER2 drugs were included. Drug consumption was expressed as defined daily doses (DDDs) and expenditure. Time series analysis was adopted to find trends in consumption, while interrupted time series was used in analyzing the impact of policy on consumption. The correlation between DDDs and defined daily cost (DDC) was analyzed by Pearson's correlation test.ResultsThe DDC, DDDs, and expenditure of anti-HER2 drugs changed little from 2012 to 2016. The DDC decreased intermittently, while the DDDs and expenditure of these drugs grew continuously from 2017 to 2021. The anti-HER2 monoclonal antibodies contributed to the majority of total consumption in 2012–2019. The DDDs of anti-HER2 tyrosine kinase inhibitors surpassed the DDDs of monoclonal antibodies in 2020–2021. Trastuzumab was the predominantly prescribed drug in 2012–2019, but the DDDs of pyrotinib surpassed the DDDs of trastuzumab in 2020–2021. The ln value of DDC or self-paid DDC of trastuzumab was negatively correlated with the ln value of its DDDs. The national health insurance coverage (NHIC) and national drug price negotiation policy about anti-HER2 drugs were initiated in 2017. Low-price generics and biosimilar of trastuzumab came into the market in 2020 and 2021, separately. Interrupted time series analysis showed that the DDDs increased significantly after the implementation of NHIC, price negotiation or generic drug replacement.ConclusionThe consumption of anti-HER2 drugs has significantly increased and their DDC has decreased after the implementation of NHIC, price negotiation, or low-price generic drug replacement since 2017. Further efforts are needed to translate the high consumption into clinical benefits.
The use of metformin for type 2 diabetes prevention: Observational multicenter study from Saudi Arabia
Authors: Alfayez Osamah M. , Alsallum Alanoud A. , Aljabri Adnan F. , Almutairi Faisal S. , Al-Azzeh Ola , Almalki Ohoud S. , Al Yami Majed S. , Almohammed Omar A. 
Published: September 2022

BackgroundPatients with prediabetes are at higher risk of developing type 2 diabetes. While intensive lifestyle modification is the primary approach to delaying diabetes, metformin has been shown to be effective, especially among patients younger than 60 years and obese (body mass index (BMI) &gt; 35 kg/m2), patients with fasting blood glucose ≥ 6.1 mmol/L or HbA1c ≥ 6%, and women with history of gestational diabetes. Thus, metformin is now recommended as an option for diabetes prevention by the American Diabetes Association (ADA). The use of metformin among patients with prediabetes in Saudi Arabia and their adherence to the guideline's recommendation for the prevention of type 2 diabetes is unknown. This study aimed to identify the prevalence of metformin use among prediabetes patients overall and patients who are more likely to benefit from metformin use per the ADA guidelines.MethodsA retrospective cohort study was conducted encompassing data from three tertiary care hospitals between January 2015 and June 2019. All patients aged 20 to 70 years with prediabetes (HbA1c of 5.7–6.4%) were included, while patients with an established diagnosis of diabetes, creatinine clearance &lt;45 ml/min, using antihyperglycemic medications other than metformin, or on metformin for other indications were excluded. Prediabetes patients who are most likely to benefit from metformin for type 2 diabetes prevention are those younger than 60 years with a BMI ≥ 35 kg/m2, patients with fasting blood glucose ≥ 6.1 mmol/L or HbA1c ≥ 6%, and women with history of gestational diabetes. This study examined the prevalence of metformin use among all patients with prediabetes, as well as patients who would be more likely to benefit from metformin use per the ADA guidelines.ResultsA total of 251 patients were included in this study; 52.2% were female, with a mean age of 47.0 (11.9) years and BMI of 32.3 (6.5) kg/m2, and the median HbA1c at baseline was 5.8% (5.7–6.0). Among the overall sample, 18 patients (7.2%) received metformin for the prevention of type 2 diabetes, 14 of those were from the groups that are more likely to benefit from metformin use per the ADA guidelines (9.9%).ConclusionsAmong individuals with prediabetes in Saudi Arabia, metformin use was very low despite the evidence supporting its safety, convenience, and efficacy. Healthcare providers seemed hesitant to medicalize prediabetes; furthermore, the low use of metformin suggests the existence of several barriers that need to be identified and resolved. Increasing providers' knowledge and awareness regarding screening and management of prediabetes is highly encouraged.
Clinical application of the “sellar barrier’s concept” for predicting intraoperative CSF leak in endoscopic endonasal surgery for pituitary adenomas with a machine learning analysis
Authors: Villalonga J. F. , Solari D. , Cuocolo R. , De Lucia V. , Ugga L. , Gragnaniello C. , Pailler J. I. , Cervio A. , Campero A. , Cavallo L. M. , Cappabianca P. 
Published: September 2022

BackgroundRecently, it was defined that the sellar barrier entity could be identified as a predictor of cerebrospinal fluid (CSF) intraoperative leakage. The aim of this study is to validate the application of the sellar barrier concept for predicting intraoperative CSF leak in endoscopic endonasal surgery for pituitary adenomas with a machine learning approach.MethodsWe conducted a prospective cohort study, from June 2019 to September 2020: data from 155 patients with pituitary subdiaphragmatic adenoma operated through endoscopic approach at the Division of Neurosurgery, Università degli Studi di Napoli “Federico II,” were included. Preoperative magnetic resonance images (MRI) and intraoperative findings were analyzed. After processing patient data, the experiment was conducted as a novelty detection problem, splitting outliers (i.e., patients with intraoperative fistula, n = 11/155) and inliers into separate datasets, the latter further separated into training (n = 115/144) and inlier test (n = 29/144) datasets. The machine learning analysis was performed using different novelty detection algorithms [isolation forest, local outlier factor, one-class support vector machine (oSVM)], whose performance was assessed separately and as an ensemble on the inlier and outlier test sets.ResultsAccording to the type of sellar barrier, patients were classified into two groups, i.e., strong and weak barrier; a third category of mixed barrier was defined when a case was neither weak nor strong. Significant differences between the three datasets were found for Knosp classification score (p = 0.0015), MRI barrier: strong (p = 1.405 × 10−6), MRI barrier: weak (p = 4.487 × 10−8), intraoperative barrier: strong (p = 2.788 × 10−7), and intraoperative barrier: weak (p = 2.191 × 10−10). We recorded 11 cases of intraoperative leakage that occurred in the majority of patients presenting a weak sellar barrier (p = 4.487 × 10−8) at preoperative MRI. Accuracy, sensitivity, and specificity for outlier detection were 0.70, 0.64, and 0.72 for IF; 0.85, 0.45, and 1.00 for LOF; 0.83, 0.64, and 0.90 for oSVM; and 0.83, 0.55, and 0.93 for the ensemble, respectively.ConclusionsThere is a true correlation between the type of sellar barrier at MRI and its in vivo features as observed during endoscopic endonasal surgery. The novelty detection models highlighted differences between patients who developed an intraoperative CSF leak and those who did not.
The Relationship Between Barriers and Drivers of COVID-19 Protective Behaviors in Germany and the UK
Authors: Mahdavian Farnaz , Warren George W. , Evensen Darrick , Bouder Frederic E. 
Published: September 2022

Objectives:To explore and evaluate the impact of factors including public risk perceptions on COVID-19 protective behaviors across the UK and Germany.Methods:We used survey data collected from a representative sample for Germany and the UK (total N = 1,663) between April and May 2021. Using a Structural Equation Model, we evaluate the role of personal health risk perceptions, official message quality, source of news, age and political orientation on COVID-19 protective behaviors in the context of German and UK risk communication strategies.Results:Personal health risk perceptions had a significant positive influence on protective behaviors. Economic risk perceptions had a negative direct influence on protective behaviors, particularly in Germany, as well as a positive indirect influence. Official message quality, use of official news sources and age had positive impacts on risk perceptions and protective behaviors. Left-wing political orientation was linked to greater likelihood of undertaking protective behaviors.Conclusion:For future pandemics, more attention should be paid to evaluating and conceptualizing different varieties of risk perceptions, risk communication strategies, and demographic variables alongside their impacts on undertaking protective behaviors.
Distúrbios da linguagem em pacientes após AVC: uma revisão sistemática
Authors: VY Rosendo Beatriz , Faustino Gonçalves Laura , De Paiva Karina Mary , Haas Patricia 
Published: September 2022

Objetivo. Verificar alterações de linguagem em pacientes adultos e idosos com diagnóstico de Acidente Vascular Cerebral (AVC). Método. Os artigos foram pesquisados ​​nas bases de dados SciELO, LILACS, PubMed, Scopus, BIREME e Web of Science, sem restrição de local, período ou idioma de publicação, foram selecionados com combinações baseadas em Medical Subject Headings (MeSH). Resultados. Dois estudos com pontuação ≥6 pontos no protocolo qualitativo proposto por Pithon et al. foram incluídos na pesquisa. Pacientes com afasia e disartria combinadas, comparados com pacientes sem alterações de linguagem apresentaram inicialmente habilidades funcionais inferiores, embora com potencial significativo de recuperação funcional nas atividades de vida diária. Conclusão. As dificuldades de comunicação decorrentes dos distúrbios de linguagem pós-AVC são responsáveis ​​por afetar os pacientes, principalmente no que se refere ao compromisso social, humor, atividades da vida diária e qualidade de vida.
Pengaruh Variasi Faktor Air Semen Terhadap Kuat Tekan dan Porositas Pada Beton Porous
Authors: Puspita Sari Neri , Haniza Sjelly , Fajar Ahlan 
Published: September 2022

Beton porous merupakan beton khusus yang memiliki porositas tinggi yang memungkinkan air hujan dan sumber air lainya mengalir sehinga mengurangi lipasan atau air mengenang di permukaan. Beton porous diaplikasikan pada bidang datar. Pengaruh pengurangan air 0 %, 5 % dan 10 % dari Faktor Air Semen (FAS) 0,31 pada beton porous dengan bahan tambah superplastisizer sikament LN dosis 0,6 % dari berat semen. Agregat kasar yang digunakan berupa batu pecah (split) 10 - 20 mm. Pembuatan benda uji menggunakan silinder dengan diameter 15 cm dan tinggi 30 cm untuk pengujian kuat tekan. Pengujian porositas menggunakan sampel balok ukuran alas 10 cm x 10 cm, tinggi 15 cm. Sebelum pengujian dilakukan perawatan 14 hari dan 28 hari didalam air. Peningkatan kuat tekan optimum terjadi pada variasi pengurangan FAS 5 % dengan kuat tekan 12,64 MPa. Sedangkan porositas optimum pada pengurangan FAS 10 % yaitu 12, 62 %.
Perencanaan Dinding Turap di Tepi Sungai Pada Tanah Lunak
Authors: Toyeb Muhammad , Mubarak Husni , Ningrum Puspa , Yazid Muhammad 
Published: September 2022

Stability of soil on the riverbank necessary to considered towards landslide. Especially the location of soil in around it commonly have kinds the soft soil and over deformation. The large lateral earth pressure grant the influence to sheet pile stability. The face problem was embankment placed in riverbank on natural soil. It is potentially occur shear failure on embankment. Aim the study was design sheet pile to own bearing capacity in order to able withhold mainly lateral force. The source data from soil investigation report was SPT and analysis method based on soil properties, load design, lateral earth pressure, moment force. The result based on soil investigation obtained that almost 20 meters depth was soil to overly soft density. Depth of sheet pile was not reached rock soil because it mainly withhold lateral earth pressure. Therefore design of sheet pile planned to using steel sheet pile of Larssen profile 605K with length 12 m and driving depth 7 m along reinforcement to block anchor.
Switchable asymmetric acoustic field modulation via bilayer coding waveguide arrays
Authors: Wang Rui , Yang Fengbao 
Published: September 2022

Abstract
In this work, the acoustic coding waveguide array of a bilayer configuration is proposed to realize asymmetric acoustic field modulation. The designed device is composed of two types of meta-atom, Helmholtz resonator, and air cavity, with high transmittance and opposite phase responses, through which the plane wave is shaped into a focusing beam or splitting beam when input from one side but hardly transmitted when input from the other side. More uniquely, the device can be switched from unidirectional to bidirectional transmission relying on the tunable gap between two composing layers, showing potential applications in acoustic communication, isolation, and stealth.