bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative detection ofIDH‐mutant glioma using fluorescence lifetime imaging
Authors: Noble Anbunesan Silvia , Alfonso‐Garcia Alba , Zhou Xiangnan , Bec Julien , Lee Han Sung , Jin Lee‐Way , Bloch Orin , Marcu Laura 
Published: December 2022

AbstractIdentifying isocitrate dehydrogenase (IDH)‐mutation and glioma subtype during surgery instead of days later can aid in modifying tumor resection strategies for better survival outcomes. We report intraoperative identification of IDH‐mutant glioma (N = 12 patients) with a clinically compatible fluorescence lifetime imaging (FLIm) device (excitation: 355 nm; emission spectral bands: 390/40 nm, 470/28 nm, 542/50 nm). The fluorescence‐derived parameters were analyzed to study the optical contrast between IDH‐mutant tumors and surrounding brain tissue. IDH‐mutant oligodendrogliomas exhibited shorter lifetimes (3.3 ± 0.1 ns) than IDH‐mutant astrocytomas (4.1 ± 0.1 ns). Both IDH‐mutant glioma subtypes had shorter lifetimes than white matter (4.6 ± 0.4 ns) but had comparable lifetimes to cortex. Lifetimes also increased with malignancy grade within IDH‐mutant oligodendrogliomas (grade 2: 2.96 ± 0.08 ns, grade 3: 3.4 ± 0.3 ns) but not within IDH‐mutant astrocytomas. The current results support the feasibility of FLIm as a surgical adjuvant for identifying IDH‐mutant glioma tissue.
Beta 2 Adrenergic Receptor Selective Antagonist Enhances Mechanically Stimulated Bone Anabolism in Aged Mice
Authors: E. Worton Leah , Srinivasan Sundar , Threet DeWayne , Ausk Brandon J. , Huber Phillipe , Y. Kwon Ronald , Bain Steven D. , Gross Ted S. , M. Gardiner Edith 
Published: December 2022

AbstractThe anabolic response of aged bone to skeletal loading is typically poor. Efforts to improve mechanotransduction in aged bone have met with limited success. This study investigated whether the bone response to direct skeletal loading is improved by reducing sympathetic suppression of osteoblastic bone formation via β2AR. To test this possibility, we treated aged wild‐type C57BL/6 mice with a selective β2AR antagonist, butaxamine (Butax), before each of nine bouts of cantilever bending of the right tibia. Midshaft periosteal bone formation was assessed by dynamic histomorphometry of loaded and contralateral tibias. Butax treatment did not alter osteoblast activity of contralateral tibias. Loading alone induced a modest but significant osteogenic response. However, when loading was combined with Butax pretreatment, the anabolic response was significantly elevated compared with loading preceded by saline injection. Subsequent studies in osteoblastic cultures revealed complex negative interactions between adrenergic and mechanically induced intracellular signaling. Activation of β2AR by treatment with the β1, β2‐agonist isoproterenol (ISO) before fluid flow exposure diminished mechanically stimulated ERK1/2 phosphorylation in primary bone cell outgrowth cultures and AKT phosphorylation in MC3T3‐E1 pre‐osteoblast cultures. Expression of mechanosensitive Fos and Ptgs2 genes was enhanced with ISO treatment and reduced with flow in both MC3T3‐E1 and primary cultures. Finally, co‐treatment of MC3T3‐E1 cells with Butax reversed these ISO effects, confirming a critical role for β2AR in these responses. In combination, these results demonstrate that selective inhibition of β2AR is sufficient to enhance the anabolic response of the aged skeleton to loading, potentially via direct effects upon osteoblasts. © 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Serum brain‐derived neurotrophic factor in coronary heart disease: Correlation with the T helper (Th)1/Th2 ratio, Th17/regulatory T (Treg) ratio, and major adverse cardiovascular events
Authors: Huo Yanfei , Feng Qiang , Fan Jie , Huang Jing , Zhu Yanling , Wu Yanqiang , Hou Aijun , Zhu Lin 
Published: December 2022

AbstractBackgroundBrain‐derived neurotrophic factor (BDNF) exerts protective roles against dyslipidemia, atherosclerosis, and inflammation in cardiovascular diseases; meanwhile, it retards CD4+ T cell differentiation into T helper (Th)1 and Th17 cells. Hence, this study aimed to investigate the linkage of serum BDNF with Th1/Th2 ratio, Th17/regulatory T (Treg) ratio, and major adverse cardiovascular events (MACE) risk in the coronary heart disease (CHD) patients.MethodsThis prospective study detected serum BDNF in 210 CHD patients, 50 disease controls (DCs), and 50 healthy controls (HCs) using an enzyme‐linked immunosorbent assay. For CHD patients only, the proportion of Th1, Th2, Th17, and Treg cells in blood CD4+ T cells was calculated by flow cytometry.ResultsThe BDNF varied among CHD patients, DC, and HC (p < 0.001). Specifically, BDNF was declined in CHD patients compared with DCs (p < 0.001) and HCs (p < 0.001). In CHD patients, BDNF was negatively related to Th1 cells (p = 0.031), Th1/Th2 ratio (p = 0.026), Th17 cells (p = 0.001), and Th17/Treg ratio (p = 0.002). Concerning the prognosis, BDNF was reduced in patients with MACE occurrence compared to patients without MACE occurrence (p = 0.006). Furthermore, BDNF showed a trend (lacked statistical significance) to relate to longer MACE‐free survival (p = 0.059). Besides, BDNF was related to the absence of obesity (p = 0.019), decreased total cholesterol (p = 0.043), low‐density lipoprotein cholesterol (p = 0.019), C‐reactive protein (p = 0.012), and Gensini score (p = 0.005).ConclusionSerum BDNF negatively correlates with Th1/Th2 ratio, Th17/Treg ratio, and estimates lower MACE risk in CHD patients.
Excursions in Rorschachlandia: Surveying the scientific and philosophical landscape of Hermann Rorschach's Psychodiagnostics
Authors: Acklin Marvin W. 
Published: December 2022

AbstractThis article examines the milieu of Hermann Rorschach's Psychodiagnostics (1921/2021) under development between 1911 and his death in 1922 and explores new evidence about the direction Rorschach's test might have taken after publication of Psychodiagnostics. This includes direct and indirect influences from turn of the century continental philosophy and science and innovative colleagues in the Swiss psychiatric and psychoanalytic societies. The availability of newly translated scholarship, including the correspondence between Ludwig Binswanger and Hermann Rorschach following the 1921 publication of Psychodiagnostics, Binswanger's posthumous 1923 commentary in the International Journal of Psychoanalysis, and recent new translation of Psychodiagnostics, permits a fresh appraisal of the milieu and foundations of Rorschach's development. Understanding these sources and influences opens new vistas in reappraising the nature of Rorschach's “test theory” which Rorschach considered undeveloped at the time of his death. This paper presents new evidence that, under the influence of Rorschach's close colleague, Ludwig Binswanger, the Geisteswissenschaften and phenomenology might have figured prominently in future developments. The paper concludes that Rorschach, preoccupied with considerations of kinesthetic subjectivity in his innovative conceptualization of human movement responses, was a nascent phenomenologist whose untimely death cut short further developments in his theory of the test.
How do belowground bedrock fissures impact soil erosion on karst hillslopes under different rainfall intensity conditions?
Authors: Fang Qian , Zhao Longshan , Fan Chunhua , Fang Fayong , Zi Ruyi , Qian Xiaohe , Li Kaifeng 
Published: December 2022

AbstractIn karst regions, bedrock fissures are developed via karstification, which may cause belowground soil erosion (BSE). However, few studies have quantitatively assessed the effect of bedrock fissures on BSE because BSE measurement is difficult on karst hillslopes. The objective of this study was to investigate the differences in runoff and soil erosion at the surface and belowground on karst hillslopes with and without bedrock fissures (hereafter called HS1 and HS2, respectively) under different rainfall intensities (50, 75, and 100 mm hr−1). The slope gradient was 5°. In the rainfall process, surface runoff (SR), subsurface runoff (SBR), soil–rock interface flow (SRIF), and underground fissure flow (UFF) data were collected on HS1 and HS2. The results showed that the SR coefficients of HS1 and HS2 were negligible (less than 1%) under rainfall intensities of 50 and 75 mm hr−1, and UFF (56%–57%) of HS1 and SRIF (40%–44%) of HS2 dominated the runoff pattern. Under a rainfall intensity of 100 mm hr−1, the SR coefficient increased to approximately 30% under the two treatments, and the coefficients of UFF of HS1 and SRIF of HS2 decreased to 29% and 24%, respectively. Compared to HS2, UFF of HS1 increased by 18%–39%. The SBR coefficient was lower than 10% for all rainfall events. Because SR and SBR were low under rainfall intensities of 50 and 75 mm hr−1, the soil loss was dominated by UFF (99%–100% of the total sediment) of HS1 and by SRIF (86%–97% of the total sediment) of HS2. Under the 100 mm hr−1 rainfall intensity, almost all sediment was lost via SR under the two treatments, and the sediment loss of HS2 was 33% higher than that of HS1. Our results indicated that bedrock fissures caused more underground rainwater leakage at the SRI and further decreased surface soil erosion on karst hillslopes.
The local period integrals and essential vectors
Authors: Jo Yeongseong 
Published: December 2022

AbstractBy applying the formula for essential Whittaker functions established by Matringe and Miyauchi, we study five integral representations for irreducible admissible generic representations of GLnoverp‐adic fields. In each case, we show that the integrals achieve local formalL‐functions defined by Langlands parameters, when the test vector is associated to the new form. We give the relation between local periods involving essential Whittaker functions and special values of formalL‐factors at for certain distinguished or unitary representations. The period integrals are also served as standard nonzero distinguished forms.
High Q‐factor anapole mode based on localized spoof surface plasmon polaritons
Authors: Ahmed Adeel , Qin Pengfei , Li Er‐Ping 
Published: December 2022

AbstractRecently, localized spoof surface plasmon polaritons (LSSPPs) have emerged as a new research frontier due to their unique properties and potential applications in integrated circuits. The toroidal dipole is a localized electromagnetic response different from electric and magnetic dipoles. Anapole is the nonradiating source produced by the interference between identical radiation patterns of toroidal and electric dipoles in the far field. This paper proposes a novel high Q‐factor compact planar resonator consisting of split‐ring resonators to support the LSSPPs anapole at microwave frequency, which shows an apparent nonradiating charge–current configuration. In simulation and measurement, we observe the nonradiating property of the anapole mode. Further, we demonstrate that the LSSPPs anapole resonance has the tunable property, which is very sensitive to structural changes. These might lead to potential applications in the design of plasmonic deformation sensors, cloaking, and absorbers.
Towards optimal synchronization in NFV‐based environments
Authors: Alomari Zakaria , Zhani Mohamed Faten , Aloqaily Moayad , Bouachir Ouns 
Published: December 2022

AbstractNetwork Function Virtualization (NFV) is known for its ability to reduce deployment costs and improve the flexibility and scalability of network functions. Due to processing capacity limitations, the infrastructure provider may need to instantiate multiple instances of the same network function. However, most of network functions are stateful, meaning that the instances of the same function need to keep a common state and hence the need for synchronization among them. In this paper, we address this problem with the goal of identifying the optimal synchronization pattern between the instances in order to minimize the synchronization costs and delay. We propose a novel network function named Synchronization Function able to carry out data collection and further minimize these costs. We first mathematically model this problem as an integer linear program that finds the optimal synchronization pattern and the optimal placement and number of synchronization functions that minimize synchronization costs and ensure a bounded synchronization delay. We also put forward three greedy algorithms to cope with large‐scale scenarios of the problem, and we explore the possibility to migrate network function instances to further reduce costs. Extensive simulations show that the proposed algorithms efficiently find near‐optimal solutions with minimal computation time and provide better results compared to existing solutions.
Application of Thermal Response Measurements to Investigate Enhanced Water Adsorption Kinetics in Ball‐Milled C2N‐Type Materials
Authors: Du Shengjun , Leistenschneider Desirée , Xiao Jing , Dellith Jan , Troschke Erik , Oschatz Martin 
Published: December 2022

AbstractSorption‐based water capture is an attractive solution to provide potable water in arid regions. Heteroatom‐decorated microporous carbons with hydrophilic character are promising candidates for water adsorption at low humidity, but the strong affinity between the polar carbon pore walls and water molecules can hinder the water transport within the narrow pore system. To reduce the limitations of mass transfer, C2N‐type carbon materials obtained from the thermal condensation of a molecular hexaazatriphenylene‐hexacarbonitrile (HAT‐CN) precursor were treated mechanochemically via ball milling. Scanning electron microscopy as well as static light scattering reveal that large pristine C2N‐type particles were split up to a smaller size after ball milling, thus increasing the pore accessibility which consequently leads to faster occupation of the water vapor adsorption sites. The major aim of this work is to demonstrate the applicability of thermal response measurements to track these enhanced kinetics of water adsorption. The adsorption rate constant of a C2N material condensed at 700 °C remarkably increased from 0.026 s−1 to 0.036 s−1 upon ball milling, while maintaining remarkably high water vapor capacity. This work confirms the advantages of small particle sizes in ultramicroporous materials on their vapor adsorption kinetics. It is demonstrated that thermal response measurements are a valuable and time‐saving method to investigate water adsorption kinetics, capacities, and cycling stability.
Fiscal Exchange and Tax Compliance: Evidence From a Field Experiment
Authors: Schächtele Simeon , Eguino Huáscar , Roman Soraya 
Published: December 2022

AbstractBehavioral interventions appealing to taxpayers’ reciprocity often leave tax compliance unaffected. We provide evidence that a “fiscal exchange nudge” increased tax compliance in a setting where one might not expect it: crisis‐ridden Argentina. In a randomized controlled trial with over 20,000 taxpayers, a tax bill visually celebrating realized public works benefiting children increased payment rates of tax delinquents by about 20 percent, or almost 40 percent when the bills were delivered in person. Without the appeal, the new bill design generated significantly fewer payments. Changes in the design of the tax bill also increased arrears cancellation. We estimate the ratio of marginal revenues to costs for the fiscal exchange bill to be 18. The factors we associate with the unexpectedly positive impacts are consistent with strengthening an affective response. We find persistent effects of the experiment two years later. The results suggest that communities have more scope to increase tax revenues through non‐threatening interventions.
Device operation of P‐ion‐implanted n‐BaSi2/p‐Si heterojunction solar cells
Authors: Aonuki Sho , Yamashita Yudai , Limodio Gianluca , Narita Shunsuke , Takayanagi Kaori , Iwai Ai , Toko Kaoru , Zeman Miro , Isabella Olindo , Suemasu Takashi 
Published: December 2022

AbstractWe formed phosphorous(P)‐ion‐implanted n‐BaSi2 films on p‐Si(111) substrates and demonstrated solar‐cell functionality of the n‐BaSi2/p‐Si heterojunction under AM1.5 illumination. The BaSi2 films were grown by molecular beam epitaxy, followed by implantation of P ions to the BaSi2 films using PF3 gas at an energy of 10 keV and a dose of 1 × 1014 cm−2. Subsequent postannealing was conducted at 500°C in Ar for different durations (t = 30–480 s) to activate the P atoms. The diffusion coefficient for P atoms in BaSi2 was evaluated from the depth profiles of P atoms by secondary‐ion mass spectrometry. The activation energies of lattice and grain boundary diffusion were found to be 1.1 ± 0.6 and 2.5 ± 0.6 eV, respectively. From the analysis of Raman and photoluminescence spectra, the ion implantation damage was recovered by the postannealing. For one treated sample with t = 120 s, the internal quantum efficiency reached 67% at a wavelength of 870 nm. This is the highest ever achieved for n‐BaSi2/p‐Si heterojunction solar cells. Ion implantation is thus applicable to BaSi2 films grown by any other method. This achievement thereby opens a new route for the formation of BaSi2 solar cells.
Mechanically tunable supramolecular polymer networks with different triblock backbones
Authors: Yang Xue , Bai Ruixue , Zhang Zhaoming , Liu Yangang , Yan Xuzhou 
Published: December 2022

AbstractSupramolecular polymer networks (SPNs) have attracted much research attention due to their good performance in the preparation of adaptive materials. Controlling the distribution of supramolecular interactions in the networks is a good strategy to tune the properties of SPNs, but corresponding study is still rare. Herein, we construct two triblock copolymers in ABA and BAB forms to control the supramolecular interaction concentrated in A block, leading to two SPNs with divergent mechanical performances. In specific, the SPN‐1 formed by ABA triblock copolymer displays a slightly and densely distributed hard domain and a compact network, resulting in a decent toughness. While the SPN‐2 composed of BAB triblock copolymer is rigid and less elastic, whose microphase‐separated structures are more obvious, making the network difficult to withstand larger strains. These findings are conducive to deepening the understanding of SPNs and would promote the development of supramolecular block copolymers with emergent functions and applications.
Synthesis, characterization, and property of ionized nano‐objects with defined phase separation
Authors: Li Penghan , Zhou Peng , Wang Jian , Wang Guowei 
Published: December 2022

AbstractThe ionized nano‐objects with defined microphase separation were prepared and properties were investigated. Firstly, the polyisoprene‐b‐polystyrene (PI‐b‐PS) based nano‐objects were prepared through living anionic polymerization‐based polymerization‐induced self‐assembly (LAP‐PISA) technique, and the nano‐objects were in‐situ stabilized by divinylbenzene (DVB) agent. Subsequently, the PI segment on nano‐objects or (co)polymers was sequentially brominated and ionized, and the ionic pairs were introduced. The successful synthesis of the nano‐objects and the subsequent modification were comprehensively verified by multiple measurements. Furthermore, the thermal property of the nano‐objects or (co)polymers was investigated by thermogravimetric analysis (TGA) and differential scanning‐calorimetry (DSC) measurements, and the electric property was evaluated by impedance analyzer. The ionic conductivity (σ), relative permittivity (εr) and dielectric loss (tgδ) of ionized nano‐objects were compared with the counterparts of ionized, linear PI‐b‐PS and PI. The results showed that the introduction of PS segment could strengthen the ionic system, and however, reduce the electric property. With the same composition, the ionized nano‐objects should have more regular microphase separation and transportation channels for ions than that for the linear PI‐b‐PS copolymer. The σ for the former was five times of that for the latter.
Pulmonary tularaemia in a female adolescent with inflammatory bowel disease receiving infliximab: Do not miss the diagnosis
Authors: Schwarzová Veronika , Schwarz Jan , Mitrová Katarina , Dřevínek Pavel , Kreslová Marcela , Sýkora Josef , Doušová Tereza 
Published: December 2022

AbstractWe report the first described case of pulmonary tularaemia in the pediatric patient receiving infliximab for ulcerative colitis. We highlight the importance of considering Francisella tularensis in diagnostically challenging cases of persistent respiratory symptoms to facilitate early diagnosis and adequate therapy. The TCR‐γδ + DN T cells are gaining important role in clinical practice. Polymerase chain reaction assays and serology guarantee early recognition.
In silico investigation on structure–function relationship of members belonging to the human SLC52 transporter family
Authors: Ben Mariem Omar , Saporiti Simona , Guerrini Uliano , Laurenzi Tommaso , Palazzolo Luca , Indiveri Cesare , Barile Maria , De Fabiani Emma , Eberini Ivano 
Published: December 2022

AbstractRiboflavin is an essential water‐soluble vitamin that needs to be provided through the diet because of the conversion into flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), important cofactors in hundreds of flavoenzymes. The adsorption and distribution of riboflavin is mediated by transmembrane transporters of the SLC52 family, namely RFVT1‐3, whose mutations are mainly associated with two diseases, MADD and the Brown‐Vialetto‐Van Laere syndrome. Interest in RFVTs as pharmacological targets has increased in the last few years due to their overexpression in several cancer cells, which can be exploited both by blocking the uptake of riboflavin into the cancerous cells, and by performing cancer targeted delivery of drugs with a high affinity for RFVTs. In this work, we propose three‐dimensional structural models for all three human riboflavin transporters obtained by state‐of‐the‐art artificial intelligence‐based methods, which were then further refined with molecular dynamics simulations. Furthermore, two of the most notable mutations concerning RFVT2 and RFVT3 (W31S and N21S, respectively) were investigated studying the interactions between the wild‐type and mutated transporters with riboflavin.
On implementing Jeffreys' substitution likelihood for Bayesian inference concerning the medians of unknown distributions
Authors: Grieve Andrew P. 
Published: December 2022

AbstractWhen statisticians are uncertain as to which parametric statistical model to use to analyse experimental data, they will often resort to a non‐parametric approach. The purpose of this paper is to provide insight into a simple approach to take when it is unclear as to the appropriate parametric model and plan to conduct a Bayesian analysis. I introduce an approximate, or substitution likelihood, first proposed by Harold Jeffreys in 1939 and show how to implement the approach combined with both a non‐informative and an informative prior to provide a random sample from the posterior distribution of the median of the unknown distribution. The first example I use to demonstrate the approach is a within‐patient bioequivalence design and then show how to extend the approach to a parallel group design.