bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decidual innate immune cell kinetics following lipopolysaccharide challenge
Authors: St-Germain Lauren E. , Castellana Barbara , Baltayeva Jennet , Beristain Alexander G. 
Published: January 2022

ABSTRACTIn early pregnancy, macrophages (Mφ) and natural killer cells (NK) infiltrate and expand within the decidua to comprise 30% of all cellular content. These immune cell populations coordinate angiogenic and tissue remodeling processes that are needed for a healthy pregnancy. Importantly, decidual tissue-resident macrophages (trMφ) and uterine NK retain immunosurveillance properties that facilitate the targeting of infections (e.g., viral, bacterial). The timing and severity of these infections, as well as the resulting immune response, can dictate pregnancy outcome. However, little is known about the kinetics and activities of uterine myeloid and NK populations following infections. To address this knowledge gap, we defined the stepwise changes of uterine myeloid and NK subpopulations following lipopolysaccharide (LPS) challenge in a mouse model of early pregnancy. Low (25 µg/kg), moderate (50 µg/kg), and high (200 µg/kg) doses of LPS resulted in dose-dependent increases in peripheral and uterine inflammation, as well as a dose-dependent increase in the rate of fetal resorption. Compared with saline controls, mice exposed to LPS showed higher frequencies of immature monocytes, decreased TNFα-producing monocytes and Mφ, and increased conventional (c)NK expression of granzyme B in the uterus. These changes were followed by alterations in overall uterine (u)NK frequencies with increased cNK and decreased tissue resident (tr)NK. Together, this work describes how discrete levels of LPS-induced inflammation shape the innate immune cell landscape of the decidua. These findings establish insight into the stepwise immunological changes following endotoxin challenge and provide a better understanding of how inflammation controls the activity of key decidual leukocytes.Summary sentenceGraded LPS challenge in early pregnancy leads to a stepwise increase in fetal resorption and associates with distinct alterations in frequencies and activities of uterine immune cells.
Tissue-specific and repeat length-dependent somatic instability of the X-linked dystonia parkinsonism-associated CCCTCT repeat
Authors: Campion Lindsey N. , Maza Alan Mejia , Yadav Rachita , Penney Ellen B. , Murcar Micaela G. , Correia Kevin , Gillis Tammy , Fernandez-Cerado Cara , Velasco-Andrada M. Salvie , Legarda G. Paul , Ganza-Bautista Niecy G. , Lagarde J. Benedict B. , Acuña Patrick J. , Multhaupt-Buell Trisha , Aldykiewicz Gabrielle , Supnet Melanie L. , De Guzman Jan K. , Go Criscely , Sharma Nutan , Munoz Edwin L. , Ang Mark C. , Diesta Cid Czarina E. , Bragg D. Cristopher , Ozelius Laurie J. , Wheeler Vanessa C. 
Published: January 2022

AbstractX-linked dystonia-parkinsonism (XDP) is a progressive adult-onset neurodegenerative disorder caused by insertion of a SINE-VNTR-Alu (SVA) retrotransposon in the TAF1 gene. The SVA retrotransposon contains a CCCTCT hexameric repeat tract of variable length, whose length is inversely correlated with age at onset. This places XDP in a broader class of repeat expansion diseases, characterized by the instability of their causative repeat mutations. Here, we observe similar inverse correlations between CCCTCT repeat length with age at onset and age at death and no obvious correlation with disease duration. To gain insight into repeat instability in XDP we performed comprehensive quantitative analyses of somatic instability of the XDP CCCTCT repeat in blood and in seventeen brain regions from affected males. Our findings reveal repeat length-dependent and expansion-based instability of the XDP CCCTCT repeat, with greater levels of expansion in brain than in blood. The brain exhibits regional-specific patterns of instability that are broadly similar across individuals, with cerebellum exhibiting low instability and cortical regions exhibiting relatively high instability. The spectrum of somatic instability in the brain includes a high proportion of moderate repeat length changes of up to 5 repeats, as well as expansions of ∼20->100 repeats and contractions of ∼20-40 repeats at lower frequencies. Comparison with HTT CAG repeat instability in postmortem Huntington’s disease brains reveals similar brain region-specific profiles, indicating common trans-acting factors that contribute to the instability of both repeats. Analyses in XDP brains of expansion of a different SVA-associated CCCTCT located in the LIPG gene, and not known to be disease-associated, reveals repeat length-dependent expansion at overall lower levels relative to the XDP CCCTCT repeat, suggesting that expansion propensity may be modified by local chromatin structure. Together, the data support a role for repeat length-dependent somatic expansion in the process(es) driving the onset of XDP and prompt further investigation into repeat dynamics and the relationship to disease.
Self-assembled DNA nanostructures promote cell migration & differentiation of human umbilical vein endothelial cells
Authors: Gada Anjali Rajwar , Vaswani Payal , Bhatia Dhiraj 
Published: January 2022

AbstractDNA nanostructures have been explored for capabilities to influence cellular behavior and its functions. Recent times have seen the development of new emergent functionalities of DNA nanodevices as class of biomaterials with immense capacity to interface with biological systems and having vast potential in disease diagnosis and therapeutics. Being chemically robust and biocompatible in nature, DNA nanostructures have been surface modified and structurally fine-tuned to find emerging applications in the field of stem cell therapy and tissue regeneration. DNA nanostructures can be utilized for therapeutic angiogenesis that involves induction of blood vessel formation and can be used to treat ischemic diseases like stroke or heart failure. This work addresses the effect of DNA nanostructures’ structural topology in their capacity to stimulate endothelial cells angiogenesis. We tested a panel of four geometries of DNA nanostructure and checked their potential on the differentiation of human umbilical vein endothelial cells (HUVECs). While different DNA nanostructure geometries showed successful angiogenesis induction and cell migration in HUVECs, tetrahedral DNA cages showed the maximum uptake and angiogenesis potential indicating that not only the composition of materials, but also the 3D arrangement of ligands might also play role in stimulating the angiogenesis process.
The willingness to offer livestock insurance in rural China: a discrete choice experiment among Chinese insurance agents
Authors: Yang Youwei , Long Wenjun , Turvey Calum G. 
Published: January 2022

Purpose This paper investigates Chinese agricultural insurance agents willingness to offer (WTO) livestock insurance based on the variations of eight main attributes of livestock insurance.Design/methodology/approach This study implements discrete choice experiments (DCE) with actual insurance agents who design, sell and operate livestock insurance in China. The choice experiment of this study is based on the D-optimal approach, a six-block design, with 15 cards per block and two choices per card. The sample size was 211. Econometrics results are based on conditional and mixed logit models.Findings The authors find that the subsidy effect is enormous; a one level increase of subsidy leads to 3.166 times higher probability to offer. This subsidy effect is important as it confirms the endogenous structure between price and quantity in insurance offering, where subsidy does not only incentivize demand but also the supply. Another main factor of insurance investigated is the impact of different coverage types on agents' WTO. The authors find that agents prefer mortality insurance the most, followed by revenue insurance and profit insurance, while Index-Based Livestock Insurance (IBLI) is the least preferred to offer. Agents' knowledge about these newer types of insurance supports their WTO as well; thus, proper education is necessary to promote the more advanced types of livestock insurance.Research limitations/implications A limitation is that in the presence of COVID 19, and administrative issues at the local level, the sample was not randomly drawn. Nonetheless, the authors believe that there is enough diversity across participants, insurers and provinces and have done sufficient robustness checks to support results and conclusions.Practical implications This study provides further validation for the DCE research method that could potentially be applied to different analyses: using choice experiments to study insurers and reveal their preferences, through combinations of various levels of core attributes for insurance products. The findings and contribution are critical to the reform and improvement of livestock insurance in China and for insurance markets more broadly. The authors find that insurers do not place equal weights or values on insurance product attributes and do not view types of insurance equally. In other words, while farmers may hold different preferences about the type of insurance they demand, the results suggest that insurers also hold preferences in the type of insurance they sell.Originality/value So far as the authors are aware, this is the first DCE designed around the supply of insurance products with the subjects being insurance agents, marketers and executives.
Skilling the Indian youth: a State-level analysis
Authors: Ghosh Piyali , Goel Geetika , Bhongade Ankita 
Published: January 2022

Purpose Market-driven skill development initiatives are essential in India as a large segment of its educated workforce is unemployed or unemployable, with little or no job skills. The “Skill India Mission” aims at endowing the youth with skills that can increase their employability and productivity in jobs. The success of the Mission depends on State-level initiatives in tandem with the Mission. This paper analyzes the impact of job offers extended to the youth of Jharkhand State as an outcome of State-level skill development initiatives. Its broad objective is to assist the Government in the delivery of skill-based training programs.Design/methodology/approach Data were collected through a structured questionnaire administered across various districts of Jharkhand to capture the perceptions of trainees and training centers. The final sample of 498 had attended training in apparel, retail, security, automotive, food and beverage service, IT/ITES, electronics and construction. Findings Statistical analysis reveals a significant increase in the economic status of trainees after joining jobs. Other findings include apathy toward migration, a mismatch between skills gained and jobs, and a dearth of qualified trainers.Practical implications The authors recommend counseling and attitudinal restructuring of the youth, designing multi-skill training programs and promoting entrepreneurial spirit. The authors also propose a stakeholder-based approach for curriculum development to fill the demand–supply gap of training and ensure better trainee retention. The Government could benefit by focusing the skilling programs on the career adaptability of trainees. Skill development and vocational education and training may not operate in silos. Training programs could be planned to be conducted jointly through ITIs and State-level training institutions under the Skill India Mission.Originality/value This research could increase the effectiveness of skill development initiatives across India, thereby improving the socioeconomic status of the youth thus trained. The authors emphasize developing a people-centric perspective in skilling, shifting attention from the existing industry-driven approach, to strike a balance between the demand and supply sides. This perspective can optimize skill development initiatives by reducing the gap between employment demand and skill development.
Survival of the fittest: the multiple paths of entrepreneurial leadership driving adaptive innovation in uncertain environment
Authors: Lin Qin , Yi Lingfeng 
Published: January 2022

PurposeThis study aims to investigate the multiple influence paths or underlying mechanisms of entrepreneurial leadership (EL) on adaptive innovation from the perspectives of organizational learning and resource management, drawing on complex adaptive system theory.Design/methodology/approachWith a questionnaire survey of 317 senior and middle managers from different firms in China, structural equation modeling was used to test the hypothesized conceptual model, and bootstrapping method was employed to examine the multiple mediating effects.FindingsResults indicate that EL has a significant and positive effect on adaptive innovation. This relationship is partially mediated through exploitative learning, exploratory learning, resource bricolage and boundary-spanning integration, respectively. The impact of EL on adaptive innovation is also sequentially transmitted through exploitative learning and resource bricolage or exploratory learning and boundary-spanning integration.Originality/valueAdaptive innovation has become a firm competition strategy to cope with dynamic changes in current uncertain environment where EL can play its effectiveness to engage firms in such innovation activities. However, the question of why and how EL drives adaptive innovation has yet to be discussed. This study highlights the innovation effectiveness of EL and the triggering process of adaptive innovation, and contributes to several countermeasures for firms to implement leadership and innovation practices responding to uncertain environment.
Corporate environmental responsibility and innovation: empirical evidence from Vietnam
Authors: Nguyen Van Ha , Vu Nam Hoang 
Published: January 2022

PurposeThis study aims to examine the relationship between corporate environmental responsibility (CER) practices and different types of innovation carried out by small- and medium-sized enterprises (SMEs) in Vietnam.Design/methodology/approachThe authors employ the bivariate probit model and the two-stage least squares regression model to estimate the effects of CER on process innovation and product innovation of SMEs.FindingsThe findings show that while CER is not significantly related to product innovation, it has a positive and significant effect on process innovation. Further analysis indicates that CER engagement increases labor productivity and financial performance of SMEs.Practical implicationsCorporate managers should view implementation of environmental responsibility practices as a strategy to foster process innovation and boost labor productivity and financial performance. For policy makers, government support for firms proactively engaging in CER practices could encourage firms to pursue innovative activities, which are vital to their long-term success as well as to the society's prosperity.Originality/valueThis study makes several important contributions. First, the authors provide new empirical evidence regarding the different effects of engaging in environmentally friendly practices on firm innovation in an under-examined emerging market setting. Second, the authors enrich our understanding of potential benefits of CER implementation. Third, the findings suggest that firm innovation may play a mediating role in the CER–firm performance association.
Does unemployment affect the relationship between income inequality and food security?
Authors: Haini Hazwan , Musa Siti Fatimahwati Pehin Dato , Wei Loon Pang , Basir Khairul Hidayatullah 
Published: January 2022

PurposeThis study examines whether unemployment affects the relationship between income inequality and food security in 143 advanced and developing economies from 2000 to 2019. The authors specifically explore whether unemployment can weaken the negative impact of income inequality on food security.Design/methodology/approachThe authors estimate a new and robust index of food security using a generalized least squares approach. The authors then employ the system generalized method of moments to estimate the model as it allows the authors to control for endogeneity and simultaneity. The authors estimate an interaction term to account for the moderating impact of unemployment.FindingsThe authors consistently find that income inequality has a negative and significant association with food security. However, the results differ between advance and developing economies. The authors find that unemployment rates have a negative relationship with food security in the sample of developing countries, where high levels of unemployment exacerbate the adverse effects of income inequality on food security. This is insignificant for advanced economies.Research limitations/implicationsThe major limitation lies in the use of aggregated data, which overlooks the issue of food security at the household or individual level.Practical implicationsPolicymakers in developing economies can ensure job security in order to lessen the adverse effects of income inequality on food security.Originality/valueThis study provides new empirical evidence on whether unemployment can potentially moderate and alleviate the impact of income inequality in advanced and developing economies.
Multi-criteria decision analysis of significant enablers for a competitive supply chain
Authors: Singh Satbir , Agrawal Vivek , Mohanty R.P. 
Published: January 2022

PurposeThe purpose of this research paper is to study the significant enablers for a competitive supply chain and analyze the relationships among them by using multi-criteria decision-making (MCDM) techniques. The supply chain (SC) managers will get better insights from the models of this study to design their SCs that are more competitive for competitive advantage.Design/methodology/approachAfter an extensive review of literature followed by experts' opinions, 21 significant enablers for a competitive SC (CSC) were selected for structural modeling using MCDM techniques of total interpretive structural modeling (TISM), Impact Matrix Cross-Reference Multiplication Applied to a Classification (MICMAC), followed by decision-making trial and evaluation laboratory (DEMATEL) approach.FindingsTop management commitment is the most prominent causing enabler of a CSC; customer satisfaction is the topmost effect enabler; the operational performance of individual firms in the supply chain is a crucial enabler of a CSC.Practical implicationsThe results and findings of this study would provide better insights to SC professionals and practitioners to comprehend the significant enablers of a CSC for designing and executing SC operations more competitively to achieve better customer satisfaction and sustainable business performance.Originality/valueTo the best of the authors’ knowledge, this is a foremost study focusing on the significant enablers of a CSC by utilizing the TISM along with MICMAC and DEMATEL methods. It is expected that this research will offer useful guidance for assessing and considering the SC enablers for achieving a CSC and facilitate new research in this area with more thrust.
Interactive effects of self-congruity and need for uniqueness on brand loyalty via brand experience and brand attachment
Authors: Chieng Fayrene , Sharma Piyush , Kingshott Russel PJ , Roy Rajat 
Published: January 2022

Purpose
This paper aims to examine the differences in the process by which three types of self-congruity (actual, ideal and social) interact with the need for uniqueness (NFU) to influence brand loyalty via brand experience and brand attachment.

Design/methodology/approach
An online survey with 428 members of an Australian consumer panel. The data are analyzed using the structural equation modeling (SEM).

Findings
The results show that social self-congruity (SSC) has a direct effect on the brand attachment, but actual and ideal self-congruity (ASC and ISC) influence it only indirectly through brand experience. Moreover, the NFU strengthens the positive effect of ISC but weakens the effect of SSC on brand attachment.

Research limitations/implications
This study uses publicly consumed brands and the NFU as the moderator. Future research may study privately consumer brands and use other moderators, such as regulatory focus (promotion vs prevention).

Originality/value
This study extends current research on brand attachment by highlighting the positive influence of SSC on brand attachment. It also establishes the mediating role of brand experience and the moderating role of the NFU. These are new insights about the underlying process and the boundary conditions for the well-established relationship between self-congruity and brand attachment.
Bridging the gap: why, how and when HR analytics can impact organizational performance
Authors: McCartney Steven , Fu Na 
Published: January 2022

PurposeDespite the growth and adoption of human resource (HR) analytics, it remains unknown whether HR analytics can impact organizational performance. As such, this study aims to address this important issue by understanding why, how and when HR analytics leads to increased organizational performance and uncover the mechanisms through which this increased performance occurs.Design/methodology/approachUsing data collected from 155 Irish organizations, structural equation modeling was performed to test the chain mediation model linking HR technology, HR analytics, evidence-based management (EBM) and organizational performance.FindingsThe study's findings support the proposed chain model, suggesting that access to HR technology enables HR analytics which facilitates EBM, which in turn enhances organizational performance.Originality/valueThis research contributes significantly to the HR analytics and EBM literature. First, the study extends our understanding of why and how HR analytics leads to higher organizational performance. Second, the authors identify that access to HR technology enables and is an antecedent of HR analytics. Finally, empirical evidence is offered to support EBM and its impact on organizational performance.
Grounding clinical guidelines in service users’ experiences of endings
Authors: Webb Kimberley , Schröder Thomas , Gresswell David Mark 
Published: January 2022

Purpose
The purpose of this paper is to explore service users’ experiences of the process of ending from national health service (NHS) community personality disorder services.

Design/methodology/approach
Semi-structured interviews were conducted with eight participants recruited from four NHS community personality disorder services.

Findings
Three main themes emerged; “Service users” experiences in the context of “Reflective versus Reactive practice”, “Endings held in mind” and “What next”?

Originality/value
Further recommendations are provided for practitioners supporting individuals managing endings alongside a “readiness to end” model which may be used in clinical practice.
My team makes me think I can (not) do it: team processes influence proactive motivational profiles over time
Authors: Ontrup Greta , Kluge Annette 
Published: January 2022

PurposeThis study aims to investigate cross-level influences of team cohesion, trust and conflicts on team member’s proactive motivational profiles and outcomes of profile membership over time.Design/methodology/approachData was collected in a four-month longitudinal field study with 47 teams (N = 202).FindingsLatent profile analysis derived four proactive motivational profiles. The higher motivated profiles reported better study outcomes, higher levels of team trust and cohesion and fewer conflicts over time. Team trust and interpersonal conflicts emerged as significant predictors of profile membership.Practical implicationsRecommendations are derived on how to best manage teams and the members comprising it when trust in teams is low or interpersonal conflicts are high.Originality/valueApplying a person-centred approach in a team context advances multi-level theories of team motivation by mapping the cross-level effects of team processes on different kinds of motivational states.