bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic opportunity of phosphodiesterase 3A modulators in myxoid liposarcomas
Authors: Toivanen Kirsi , Kilpinen Sami , Ojala Kalle , Murumägi Astrid , Arjama Mariliina , Merikoski Nanna , Salmikangas Sami , Kallioniemi Olli , Sampo Mika , Böhling Tom , Sihto Harri 
Published: December 2022

Abstract
Liposarcoma is a common soft tissue sarcoma, and is classified into four histological subtypes, each with distinct disease outcome, morphology, and genotype. Typical primary treatment in advanced liposarcoma consists of surgery, combined with chemotherapy, radiotherapy, or both. There are currently no approved targeted therapeutics or precision medicine opportunities in liposarcoma. Here we investigated 131 liposarcoma tumour samples by transcriptional profiling and 543 sarcomas by immunoprofiling and compared these data with high-throughput drug sensitivity testing in liposarcoma cell lines in vitro. The data showed that i) myxoid liposarcomas, specifically the high-grade phenotype, display high levels of PDE3A gene expression and that ii) PDE3A modulators are effective inhibitors in PDE3A and SLFN12 co-expressing soft tissue sarcoma cell lines. iii) In addition, PDE3A modulators synergize with many emerging targeted therapies and sensitize sarcoma cell lines to Bcl-2 family inhibitors. We suggest that overexpression of PDE3A and SLFN12 genes is common in myxoid liposarcomas and that this leads to sensitivity to PDE3A modulators and synergy with Bcl-2 family inhibition. Further studies are warranted to translate these observations into precision liposarcoma therapy.
Myocardial Infarction in patients with severe beta thalassaemia: A case series
Authors: Premawardhena Anuja , De Silva Shamila , Rajapaksha Megha , Ratnamalala Visaka , Nallarajah Jemimah , Galappatthy Gamini 
Published: December 2022

Abstract
Back Ground: Cardiac disease remains a dominant if not the most important cause of morbidity and mortality in patients with thalassaemia, particular in those with thalassaemia major. Myocardial infarction and coronary artery disease however is rarely reported.
Case Presentations: Three older patients with three distinct thalassaemia syndromes presented with acute coronary syndrome. Two were heavily transfused whilst the other was a minimally transfused patient. Both heavily transfused patients had ST-elevation myocardial infarctions (STEMI) while the minimally transfused patient had unstable angina. Coronary angiogram (CA) was normal in two patients. One patient who developed a STEMI had a 50% plaque. All three were managed as standard ACS, although the aetiology appeared non-atherogenic.
Conclusions: The exact etiology of the presentation, remains a mystery and therefore the rational use of thrombolytic, carrying out angiogram in the primary setting, using and continuing antiplatelet and high dose statins all remains unclear in this sub group of patients.
Global, regional, and national time trends in incidence, prevalence, years lived with disability for uterine fibroids, 1990-2019: An age- period-cohort analysis for the Global Burden of Disease 2019 study
Authors: Lou Zheng , Huang Yizhou , Li Shuting , Luo Zhou , Li Chunming , Chu Ketan , Zhang Tao , Song Peige , Zhou Jianhong 
Published: December 2022

Abstract
Background: Uterine fibroids are the most common benign neoplasm of the uterus and a major source of morbidity for women. We report an overview of trends in uterine fibroids of incidence, prevalence, years lived with disability (YLDs) in 204 countries and territories over the past 30 years and associations with age, period, and birth cohort.
Methods: The incidence, prevalence, and YLDs were derived from the Global Burden of Disease 2019 (GBD 2019) study. We utilized an age-period-cohort (APC) model to estimate annual percentage changes in age-standardized rate (ASR) for incidence, ASR for prevalence, ASR for YLDs (net drifts), annual percentage changes from 10 - 14 years to 65 - 69 years (local drifts), period and cohort relative risks (period/cohort effects) between 1990 to 2019.
Results: Globally, the incident cases, prevalent cases, and the number of YLDs of uterine fibroids increased from 1990 to 2019 with the growth of 67.07%, 78.82% and 77.34%, respectively. High Socio-demographic Index (SDI) and high-middle SDI quintiles with decreasing trends (net drift < 0.0%), and increasing trends (net drift > 0.0%) were observed in middle SDI, low-middle SDI, and low SDI quintiles in annual percentage change of ASR for incidence, ASR for prevalence and ASR for YLDs over the past 30 years. There were 186 countries and territories that showed an increasing trend in ASR for incidence, 183 showed an increasing trend in ASR for prevalence and 174 showed an increasing trend in ASR for YLDs. Moreover, the effects of age on uterine fibroids increased with age and peaked at 35 - 44 years and then declined with advancing age. Both the period and cohort effects on uterine fibroids showed increasing trend in middle SDI, low-middle SDI and low SDI quintiles in recent 15 years and birth cohort later than 1965.
Conclusions: The global burden of uterine fibroids is becoming more serious in middle SDI, low-middle SDI and low SDI quintiles. Raising awareness of uterine fibroids, increasing medical investment and improving levels of medical care are necessary to reduce future burden.
Anticancer properties of red beetroot hydro-alcoholic extract and its main constituent; Betanin on colorectal cancer cell lines
Authors: Saber Amir , Abedimanesh Nasim , Somi Mohammad-Hossein , Khosroushahi Ahmad Yari , Moradi Shima 
Published: December 2022

Abstract
Colorectal cancer (CRC) is the third most common type of cancer worldwide. Red beetroot (Beta vulgaris) contains Betanin as its major betacyanin, possessing wide proapoptotic effects. This study aimed to investigate the anticancer and pro-papoptotic effects of beetroot hydro-alcoholic extract (BHE) and betanin, on colorectal cancer cell lines. BHE and betanin were used to treat Caco-2 and HT-29 colorectal cancer cells. MTT assay, DAPI staining, and FACS-flow cytometry tests were used to determine the half-maximal inhibitory concentration (IC50) and apoptosis-inducing evaluations. Intended genes were assessed by real-time polymerase chain reaction (RT-PCR). The IC50 for HT-29 and Caco-2 cell lines were 92 µg/mL, 107 µg/mL for BHE, and 64 µg/mL, 90 µg/mL for betanin at 48 h, respectively. BHE and betanin significantly inhibited the growth of both cancer cell lines time and dose-dependently. DAPI staining and flow cytometry results revealed significant apoptosis symptoms in treated cancerous cell lines. The expression level of proapoptotic genes (BAD, Caspase-3, Caspase-8, Caspase-9, and Fas-R) in treated HT-29 and Caco-2 cells was higher than in untreated and normal cells. In contrast, the anti-apoptotic gene (Bcl-2) was significantly downregulated. BHE and betanin effectively inhibited cancer cell proliferation and induced apoptosis via the modification of effective genes.
Assessment of knowledge, attitude and practice of kangaroo mother care among postnatal women attending at Hiwot Fana Specialized University Hospital, Harar Town, Eastern Ethiopia
Authors: Yezengaw Telksew Yelma 
Published: December 2022

Abstract
Background: - Kangaroo Mother Care is a powerful method to promote the health and well-being of Low Birth Weight babies. One of the main reasons that Low Birth Weight babies are at greater risk of illness and death is that they lack ability to control their body temperature. Globally 25 mil-lion infants (17%) are born with a low birth weight and most of these occur in low-income countries.
Objective: - The aim this study is to assess knowledge, attitude and practice of Kangaroo mother care among mothers in Hiwot Fana comprehensive and specialized university hospital, Eastern Ethiopia.
Method:- A cross-sectional study was employed on mothers admitted to post-natal ward in Hiwot Fana comprehensive and specialized university hospital from January 12/2021 to January 26/2021. Random sampling method was used to select the study participants. The data was collected using semi structured interview administered questionnaire by four female data collectors who have diploma in midwifery/nursing. After checking completeness, the collected data was entered in to SPSS version 22.0 for analysis. The result of analysis was presented by using frequencies, summary measures, texts, tables, Charts and graphs
Result: - The overall study finding revealed that 34.1% mothers who participated in this study had good knowledge and 65.9% had poor knowledge towards KMC. About 18.9% respondent had positive attitude and 81.1% had negative attitude. In regards of practice, 18.4 % good and 81.6% had poor practice towards KMC.
Conclusion and Recommendation:-This study shows that there is poor knowledge, negative attitude and poor practice of KMC. Giving awareness on KMC as well as practice, training were significantly associated with level of knowledge and practice. Moreover, orientation was statistically associated with attitude. Thus, intervention that should focus on creating awareness, training KMC and positive attitude creation are required to strengthen KMC knowledge, attitude and practice in postnatal mothers.
Late Initiation of Antenatal Care and Associated Factors Among Antenatal Care Attendees in governmental Health Centers of Harar Town, Ethiopia
Authors: Yezengaw Telksew Yelma 
Published: December 2022

Abstract

Introduction: Antenatal care is a type of care given for women during pregnancy and is a key strategy for reducing maternal and neonatal morbidity and mortality. The goal of Antenatal care is to prevent health problems of pregnant women through detection of complications and treatment of pregnancy related illness.
Objective: This study aims to Assessment late initiation of antenatal care and associated factors among antenatal care attendants in Governmental Health Centers of Harar Town, Ethiopia March 05 – 20/2020.
Methodology: A quantitative cross-sectional institution based study was used to assess late initiation of antenatal care and factors associated with it in Governmental Health Centers of Harar Town. The sampling technique was Systematic random sampling method was used. Two hundred Seven pregnant women who attend ANC were included in this study. Data was entered, coded and analyzed using SPSS, version 20. Descriptive statistics like frequencies and percentages was used to present the result.
Result: Out of 207 pregnant mothers included in this study, 136 (65.7%) pregnant mothers started their first ANC visit early while the remaining 71 (34. %) pregnant mothers started ANC late. Multivariate analysis revealed that Age, Gravidity and Waiting time were associated with independent variable. Those women whose age group 20-25 years were 3 times more likely having early booking than those age group less than 20 years (AOR=3.374,95% CI=[1.117-10.189] women who had gave live birth were 2 times more likely having early booking than those women who had a history of child death(AOR=2.686,95% CI=[1.005-7.178] Those women had waited time of 1:30-2hours before having the service were 18% less likely having early booking than those women who had waited for less than 30minute (AOR=0.082,95%CI: 0.007-1.019)
Conclusion: The results of this study indicated that two-third of the respondents had started their ANC within the recommended time (65.7%) and the rest one-third were booked late (34.3%). The Respondents educational level, knowledge on the importance of ANC service utilization, Source of the information which contributed to book timely for the current pregnancy and the advice given on the time of first ANC booking are significantly and positively influenced early initiation of ANC in Harar.
Risk factors of lethal outcomes of tuberculosis in a region with low population density (Kamchatskiy kray)
Authors: Gromov A. V. , Sterlikov S. A. , Mikhaylova Yu. V. 
Published: December 2022

The objective: evidence-based study of the factors inﬂuencing tuberculosis mortality in the Kamchatskiy Kray as a territory withlow population density.Subjects and Methods. A retrospective cohort study of the unfavorable course of tuberculosis in 512 patients with tuberculosis (new cases and relapses) was carried out. A univariate and multivariate analysis of risk factors for a lethal outcome of tuberculosis was performed.Results. In a univariate analysis, the incidence of death from tuberculosis among increased in older patients (p < 0.0001), among the unemployed, pensioners and disabled (p = 0.02), homeless (p = 0.01), persons who failed to undergo ﬂuorography for 2 years or more (p = 0.004), patients with a positive result of sputum smear test at registration (p = 0.003), and those suﬀering from alcoholism (p = 0.03), and decreased in patients who were actively detected (p < 0.0001 ). There was no inﬂuence on the probability of death from tuberculosis in the registration group by such parameters as new cases/relapses (p = 0.2), male/female (p = 0.09), urban/rural area of residence (p = 0.7), belonging to the indigenous population (p = 0.6), resistance to rifampicin (p = 1), cardiovascular diseases (p = 0.5), and smoking (p = 0.3). In multivariate analysis, an independent factor that reduced the risk of death was the active detection of tuberculosis patients (aOR = 0.2, p = 0.02).Conclusion. To reduce the risk of death from tuberculosis in an area with low population density (Kamchatskiy Kray), the priority should be given to improvement of active detection of tuberculosis cases; the proportion of tuberculosis patients detected during preventive screening should be used as an parameter of this improvement.
Assessing the Borta Reservoir using physicochemical parameters, Oromia Regional State, Ethiopia
Authors: Kuma Tolera , Hailu Yohanis 
Published: December 2022

Abstract
This study was conducted in the Borta Reservoir (Ethiopia) to portray physicochemical parameters between September 2018 and July 2019 for three data collection sessions. Accordingly, the sampling site was purposely selected perimeter-wise from the Borta Reservoir based on the distance from human settlements; anthropogenic effect and accessibility for the study three stations (sampling sites) were purposely selected perimeter-wise and the sites were coded as Site one (S1), site two (S2), and site three (S3). Water samples were collected monthly for three sample collection sessions. Samples were collected from each site and transported to the Limnology Laboratory and other parameters were measured on-site using a pre-calibrated portable instrument. SPSS version 20 was used for the statistical analysis. The recorded physicochemical parameters were in the range of freshwaters. It was evident that the Borta Reservoir had been showing signs of water quality loss over time. This could have resulted from stressors linked to anthropogenic sources from domestic wastes and pollutants from agricultural lands. This study suggested a restoration action be undertaken.
Tracheostomy-related Tracheal Tears in Pediatrics
Authors: Alenezi Mazyad , Alsudays Ali , Alanazy Sultan , Almashharawi Eman , Bawazir Samir 
Published: December 2022

Introduction:
Tracheostomy-related tracheal tear is a serious complication that may follow surgical or percutaneous tracheostomy. Pediatric populations carry a higher risk because of anatomical differences. The aim of this article is to review this condition and to help in its diagnosis and management with the assistance of clinical and radiological findings.

Materials and Methods:
An English literature review was done using the terms pediatric, tracheostomy, tracheal tear and tracheostomy tube.

Result:
Two cases reported in the literature met the criteria to be included in the review.

Discussion:
Tracheostomy-related tracheal tear needs immediate diagnosis as it may lead to life-threatening outcomes, such as pneumothorax, respiratory distress, extensive subcutaneous emphysema and pneumomediastinum. Symptoms and complications of the tear may occur intraoperatively or postoperatively. Gold standard methods for diagnosis include flexible or rigid tracheobronchoscopy, which helps in determining the management plan. The treatment choices for iatrogenic tracheal tears depend on the tear site, size, and extension of the tear and patient’s hemodynamic status. Conservative management is sufficient for stable patients with small tears, whereas surgical management is essential for unstable patients and those with large or complicated tears.

Conclusion:
Tracheostomy-related tracheal tear is a serious rare complication. The pediatric age group carries a higher risk of the condition and its management, either conservative or surgical, depends on airway endoscopy findings and patient’s hemodynamic status.
Bibliometric and Semantic Analysis of the Global Research on Biomarkers in Personalized Medicine
Authors: Khakimova Aida , Rahim Fakher , Zolotarev Oleg 
Published: December 2022

Aim:
The aims of the research were to study the citation history of popular articles in the field of biomarkers in personalized medicine, to study the use of terms in the sections of articles, and to consider the key terminology of the most-cited articles and its visualization.

Background:
The article describes approaches to the analysis of publication activity in the field of biomarkers and personalized medicine based on the data from the Web of Science.

Objective:
The aim of this study is a bibliometric and semantic analysis of the investigation field related to the application of biomarkers for the purposes of personalized medicine.

Methods:
The evaluation of a number of publications and its’ citations was carried out. The key terms extracted from the most-cited articles were divided into thematic groups. The number of citations of the most popular articles since 2011 was estimated.

Results:
The citation histories of the top ten articles were considered. Analysis of key terms from different parts of the most-cited articles included statistics and thematic ranking. The comparison of key terms from the most-cited article and the citing articles allowed us to show that the key terminology of the cited article extends to the citing articles. We presented the key terms of the most-cited articles as a terminological map.

Conclusion:
The study of citation of the articles in the field of personalized medicine and biomarkers was based on a survey on the Web of Science. Based on the analysis of a number of citations the trends and citation histories were constructed. The statistical and thematic analysis of the use of keywords in different sections of articles was done. We have shown that the citing articles spread the key terms of the cited article to identify trends in knowledge development which could be presented as a terminological map.

Others:
We presented the results in the form of a terminological map of the latest developments in the field of biomarkers in personalized medicine based on proposed principles.
Higher Scores of Ambient Temperature, Sunshine Hours and UV Index are Associated with Lower COVID-19 Mortality
Authors: Errasfa Mourad 
Published: December 2022

Background:
Following two years of the COVID-19 pandemic, thousands of deaths were registered around the world. A question on whether climate parameters in each country could or not affect coronavirus incidence and COVID-19 death toll is under debate.

Objective:
In this work, we aimed to analyse possible relation between the prevalence of COVID-19 deaths and the geographic latitude. The study focused on the geographic latitudes and some of their associated climate factors, such as the average annual level of temperature, sunshine hours and UV index.

Methods:
We sought the number of the deaths caused by COVID-19 in 39 countries. Latitude levels were plotted against the average annual levels of either temperature, sunshine hours or UV index. Data were analysed by simple linear regression or polynomial regression, by means of Microsoft Excel software (2016).

Results:
When COVID-19 death numbers were plotted against geographic latitudes, we obtained inverted bell-shaped curves, for both the first and second year of the pandemic, with a coefficient of determination of (R2 = 0,32) and (R2 = 0,39), respectively. In addition, COVID-19 death numbers were very negatively correlated with the average annual levels of temperature (R2 = 0,52, P= 4.92x10-7), sunshine hours (R2 = 0,36, P= 7.68x10-6) and UV index (R2 = 0,38, P= 4.16x10-5). Bell-shaped curves were obtained when latitude was plotted against the average annual number of temperature, sunshine hours and UV index, with a coefficient of determination of (R2 = 0,85), (R2 = 0,452) and (R2 = 0,87), respectively.

Conclusion:
In contrast to high-latitude countries, countries located at low latitudes may have suffered less COVID-19 death tolls, thanks to their elevated temperature, sunshine hours and UV index. The above climate factors, in addition to yet unknown factors, could have impaired the spread of the coronavirus and/or helped individual’s natural immunity to fight COVID-19 disease.
Evaluation of Phytochemical Properties and Biological Activities of Leaf Extracts and Oil of <i>Petroselinum sativum</i> Collected from Algeria
Authors: Benmekhbi Lotfi , Mosbah Salima , Laamraoui Hanane , Hamlaoui Ikram , Bencheriet Serhouda , Ibrahim Demirtas 
Published: December 2022

Indigenous medical professionals prescribe plant-based therapeutics for the handling of a range of maladies and use typical medical care at the preventive level. Oxidative stress, obesity, and multidrug resistance to pathogenic microorganisms are major challenges in the healthcare systems and pharmaceutical industries. This study aimed to screen phytoconstituents, estimate total phenol and flavonoid contents, and evaluate the antioxidant, and antimicrobial activities of Petroselinum sativum extracts and essential oil growing in Algeria. The antioxidant capacity of n-butanol, dichloromethane extracts and essential oil was determined by using DPPH radical scavenging method. All extracts were also evaluated against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacterial species using the disk diffusion method. The leaves are pharmacologically active and related to the detected phytochemical components. In the proximate analysis, plant nutrients that are important for diverse pharmacological activities are found in the leaves. The ethyl acetate extract of P. sativum showed the highest phenol content while the n-butanol and ethyl acetate extracts gave high flavonoid contents at 144.44 ± 0.07 and 100.97 ± 0.04 mg/g, respectively. The antioxidant results demonstrate powerful free radical scavenging activity for three extracts. The activity reduced in the following order as concentration increased n-BuOH > AE > DCM.