bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Supported Discharge and Transitional Care Management After Stroke: A Systematic Review and Meta-Analysis
Authors: Jee Sungju , Jeong Minah , Paik Nam-Jong , Kim Won-Seok , Shin Yong-Il , Ko Sung-Hwa , Kwon In Sun , Choi Bo Mi , Jung Yunsun , Chang Wonkee , Sohn Min Kyun 
Published: March 2022

ObjectiveTo investigate the available evidence on early supported discharge (ESD) and transitional care (TC) delivery service in patients with cerebrovascular disease.MethodsA systematic literature search was conducted to collect all available evidence on the use of ESD and TC services. We included cluster-randomized pragmatic trials or randomized controlled trials (RCTs) that recruited patients with stroke or transient ischemic attack to receive either conventional care or any care service intervention that included rehabilitation or support provided by professional medical personnel with the aim of accelerating and supporting home discharge. Relevant data were electronically searched through international databases (Cochrane Library, EMBASE, and PubMed) and incorporated into a summary grid to investigate research outcomes and provide a narrative synthesis. Furthermore, we compared the outcomes in terms of length of hospital stay, patient and caregiver outcomes, and mortality through meta-analysis.ResultsWe identified and included a total of 20 publications of various original randomized studies. There were 18 studies conducted in western countries and 2 in eastern countries. The meta-analysis revealed a tendency that ESD or TC could decrease the length of hospital stay more than the usual care [standardized mean difference (SMD) −0.13; 95% confidence interval (CI) −0.31 to 0.04 days; P = 0.14]. Moreover, there was a tendency that ESD resulted in better activities of daily living (ADL) than usual care (SMD 0.29; 95% CI −0.04 to 0.61; P = 0.08). Patient outcome based on modified Rankin scale (mRS) score (SMD −0.11; 95% CI −0.38 to 0.17; P = 0.45] and mortality (odds ratio 0.80; 95% CI 0.56–1.17; P = 0.25) did not reveal any significant difference. The Caregiver Strain Index revealed no difference.ConclusionWe did not find a large effect size for the use of TC and ESD. When implementing the TC and ESD model from western to Asian countries, services should be prepared and implemented in accordance with national medical rehabilitation pathways for cerebrovascular disease.
Bioinformatics and Experimental Analysis of the Prognostic and Predictive Value of the CHPF Gene on Breast Cancer
Authors: Li Wan-Wan , Liu Bin , Dong Shu-Qing , He Shi-Qing , Liu Yu-Ying , Wei Si-Yu , Mou Jing-Yi , Zhang Jia-Xin , Liu Zhao 
Published: March 2022

BackgroundRecent studies in the United States have shown that breast cancer accounts for 30% of all new cancer diagnoses in women and has become the leading cause of cancer deaths in women worldwide. Chondroitin Polymerizing Factor (CHPF), is an enzyme involved in chondroitin sulfate (CS) elongation and a novel key molecule in the poor prognosis of many cancers. However, its role in the development and progression of breast cancer remains unclear.MethodsThe transcript expression of CHPF in the Cancer Genome Atlas-Breast Cancer (TCGA-BRCA), Gene Expression Omnibus (GEO) database was analyzed separately using the limma package of R software, and the relationship between CHPF transcriptional expression and CHPF DNA methylation was investigated in TCGA-BRCA. Kaplan-Meier curves were plotted using the Survival package to further assess the prognostic impact of CHPF DNA methylation/expression. The association between CHPF transcript expression/DNA methylation and cancer immune infiltration and immune markers was investigated using the TIMER and TISIDB databases. We also performed gene ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis with the clusterProfiler package. Western blotting and RT-PCR were used to verify the protein level and mRNA level of CHPF in breast tissue and cell lines, respectively. Small interfering plasmids and lentiviral plasmids were constructed for transient and stable transfection of breast cancer cell lines MCF-7 and SUM1315, respectively, followed by proliferation-related functional assays, such as CCK8, EDU, clone formation assays; migration and invasion-related functional assays, such as wound healing assay and transwell assays. We also conducted a preliminary study of the mechanism.ResultsWe observed that CHPF was significantly upregulated in breast cancer tissues and correlated with poor prognosis. CHPF gene transcriptional expression and methylation are associated with immune infiltration immune markers. CHPF promotes proliferation, migration, invasion of the breast cancer cell lines MCF-7 and SUM1315, and is significantly enriched in pathways associated with the ECM-receptor interaction and PI3K-AKT pathway.ConclusionCHPF transcriptional expression and DNA methylation correlate with immune infiltration and immune markers. Upregulation of CHPF in breast cancer promotes malignant behavior of cancer cells and is associated with poorer survival in breast cancer, possibly through ECM-receptor interactions and the PI3K-AKT pathway.
Lysosome-Targeted Biosensor for the Super-Resolution Imaging of Lysosome–Mitochondrion Interaction
Authors: Wang Han , Fang Guiqian , Chen Huimin , Hu Maomao , Cui Yajuan , Wang Boyang , Su Yudong , Liu Yu , Dong Bo , Shao Xintian 
Published: March 2022

Background: The interaction between lysosomes and mitochondria includes not only mitophagy but also mitochondrion–lysosome contact (MLC) that enables the two organelles to exchange materials and information. In our study, we synthesised a biosensor with fluorescence characteristics that can image lysosomes for structured illumination microscopy and, in turn, examined morphological changes in mitochondria and the phenomenon of MLC under pathological conditions.Methods: After designing and synthesising the biosensor, dubbed CNN, we performed an assay with a Cell Counting Kit-8 to detect CNN’s toxicity in relation to H9C2 cardiomyocytes. We next analysed the co-localisation of CNN and the commercial lysosomal probe LTG in cells, qualitatively analysed the imaging characteristics of CNN in different cells (i.e. H9C2, HeLa and HepG2 cells) via structured illumination microscopy and observed how CNN entered cells at different temperatures and levels of endocytosis. Last, we treated the H9C2 cells with mannitol or glucose to observe the morphological changes of mitochondria and their positions relative to lysosomes.Results: After we endocytosed CNN, a lysosome-targeted biosensor with a wide, stable pH response range, into cells in an energy-dependent manner. SIM also revealed that conditions in high glucose induced stress in lysosomes and changed the morphology of mitochondria from elongated strips to round spheres.Conclusion: CNN is a new tool for tracking lysosomes in living cells, both physiologically and pathologically, and showcases new options for the design of similar biosensors.
Spatial Distribution and Factors Associated With Risky Health Behavior Among Adult Males Aged 15–59 Years in Ethiopia: Generalized Structural Equation Modeling
Authors: Kebede Sewnet Adem , Weldesenbet Adisu Birhanu , Tusa Biruk Shalmeno 
Published: March 2022

BackgroundAlcohol drinking and tobacco smoking are the largest preventable causes of death and important risk factors for a number of non-communicable diseases and cause premature death and many socioeconomic consequences. Therefore, the present study is aimed to assess the spatial distribution of risky health behavior and its associated factors among adult males in Ethiopia.MethodsAll men (12,688) within the age range of 15–59 years were included in the final analysis. The distribution of risky health behavior across the country was observed by using ArcGIS software. In SaTScan software, the Bernoulli model was fitted by Kulldorff methods to identify the purely spatial clusters of risky health behavior. Generalized Structural Equation Model (GSEM) was used to determine factors associated with risky health behavior (regular alcohol drinking and tobacco smoking).ResultsRisky health behavior had spatial variation across the country. The primary clusters were located in Tigray, Amhara, and north-eastern Benishangul national regional states. Spatial scan statistics identified 118 primary clusters [Log-Likelihood ratio (LLR) = 524.8, p &lt; 0.001]. Residence, frequency of listening to a radio, occupation, and frequency of watching television were significantly associated with drinking alcohol, whereas wealth index was associated with tobacco smoking. Age, region, educational status, marital status, and religion had association with both domains of risky health behavior.ConclusionRisky health behavior had spatial variation across the country. Bans on advertising and promotion of alcohol and tobacco on national press media should be strengthened. Aggressive health education efforts should be directed toward this high-risk population (Tigray, Amhara, and north-eastern Benishangul regional states). Improving risky health behavior is an important approach to reducing health disparities and promoting a more cost-effective utilization of scarce resources in the public health sector.
Compliance of Patients with Alcohol Dependence and Aggressive Behavior in a State of Intoxication
Authors: Сайков А.Д. , Скугаревский О.А. 
Published: March 2022

В статье анализируются результаты собственных исследований авторов связи типов комплаенса с агрессивным поведением пациентов с синдромом алкогольной зависимости в состоянии интоксикации. Для этого сравниваются группы пациентов с алкогольной зависимостью с объективно доказанными случаями агрессивного поведения разной степени выраженности на фоне алкогольной интоксикации и пациенты, не имеющие в анамнезе объективных данных об открыто проявляемом агрессивном поведении. Авторы приходят к выводу, что у пациентов, имевших многократную судимость, связанную с гетероагрессивным поведением в состоянии интоксикации алкоголем, были выявлены формы комплаенса, не имеющие места у неагрессивных пациентов и пациентов, имевших однократную судимость.
The article analyzes the results of the authors‘ own research on the relationship of compliance types with aggressive behavior of patients with alcohol dependence syndrome in a state of intoxication. To do this, we compare groups of patients with alcohol dependence with objectively proven cases of aggressive behavior of varying degrees of severity against the background of alcohol intoxication and patients who do not have a history of objective data on openly manifested aggressive behavior. The authors conclude that in patients who had multiple criminal records associated with heteroaggressive behavior in a state of alcohol intoxication, forms of compliance that do not occur in non- aggressive patients and patients who had a single criminal record were identified.
Estudio del comportamiento fluviométrico e hidrológico superficial de una cuenca del sur de la Región Pampeana con datos limnigráficos diarios instantáneos
Authors: Fernández Sandra , Sequeira Mario , Espósito Martín , Paoloni Juan 
Published: March 2022

Este trabajo pretende conocer las características hidrológicas superficiales fundamentales del sistema conformado por las Subcuencas Superiores y Media Alta del Río Sauce Chico, hasta la estación limnigráfica HL6005 (Nueva Roma – Ruta Nacional 35). El río se desarrolla sobre una superficie total de 1573 km2 con un colector principal de 104.5 km de longitud que nace en las Sierras Australes en la provincia de Buenos Aires. La compleja situación de la agricultura de riego en diferentes tramos del valle, crea la necesidad de un primer diagnóstico de la potencialidad del aprovechamiento integral y sustentable de los recursos de suelo y agua para el área de estudio. Se analiza la información fluviométrica diaria instantánea disponible, se examina la pluviometría zonal, la evapotranspiración y las posibilidades de escurrimientos mensual, anual y de evento. Se aplica un programa de simulación hidrológica que entrega los hidrogramas de salida de cada subcuenca, caudales máximos, tiempos de pico y volúmenes de escurrimiento a partir de un evento individual de tormenta. Desde el punto de vista de la oferta para riego, la duración de caudales medios mensuales para porcentajes de probabilidad de ocurrencia del 90, 50 y 10%, determina caudales promedios de 0.51, 1.63 y 3.98 m3/s, respectivamente.
Strategi, Hambatan, dan Tantangan Penanaman Nilai-Nilai Kesantunan Berbahasa Pada Siswa Sekolah Dasar di Masa Pandemi Covid-19
Authors: Arum Dewi Puspa , Kurniawan Hindra , Hanik Siti Umi , Anggraeni Natalia Desy 
Published: March 2022

<p>Perubahan yang sangat signifikan dari pembelajaran luring menjadi daring memunculkan sisi positif dan negatif, terutama dalam pendidikan moral, karakter dan kesantunan berbahasa. Tujuan penelitian ini adalah untuk mendeskripsikan (1) Strategi penanaman nilai-nilai kesantunan berbahasa dalam pembelajaran daring, (2) Hambatan penanaman nilai-nilai kesantunan berbahasa dalam pembelajaran daring, dan (3) Tantangan penanaman nilai-nilai kesantunan berbahasa dalam pembelajaran daring. Penelitian ini berjenis deskriptif kualitatif. Objek penelitian ini adalah guru dan siswa dalam mata pelajaran Bahasa Indonesia jenjang sekolah dasar. Teknik pengumpulan data dalam penelitian ini menggunakan wawancara mendalam, observasi, dan dokumentasi unsur kebahasaan yang terkait dengan kesantunan berbahasa yang diperoleh dari kelas daring <em>Zoom Meeting </em>dan <em>Group Whatsapp</em>. Teknik analisis data menggunakan Model Interaktif dari Miles dan Huberman. Pengujian data dalam penelitian ini menggunakan teknik triangulasi. Hasil analisis data disajikan dalam bentuk deskripsi kualitatif dengan metode informal. Diperoleh hasil penelitian bahwa kesantunan berbahasa siswa sekolah dasar di masa pandemi Covid-19 masih belum bisa dikatakan baik. Masih banyak peserta didik yang menggunakan bahasa-bahasa yang kurang sopan ketika berinteraksi dengan teman sebayanya. Hal tersebut disebabkan oleh faktor lingkungan yang kurang baik sehingga dapat mempengaruhi peserta didik dalam bertutur. Penggunaan media sosial dan game juga menjadi faktor penting dalam perubahan penggunaan kata-kata yang sopan. Perlu diterapkan strategi-strategi untuk memperbaiki pola penggunaan bahasa yang lebih sopan dengan pola pembiasaan dan pemberian teladan bagi peserta didik. Namun, penerapan pola tersebut tidak terlepas dari hambatan dan tantangan yang ada seperti kurangnya pendampingan dan pengetahuan orang tua, lingkungan di luar sekolah dan keluarga yang kurang baik, dan penggunaan sosial media yang berlebihan dan tanpa pengawasan.</p>
Dampak Pandemi Covid-19 Terhadap Pendapatan Masyarakat
Authors: Anastasia Wadan Novita , Ba’diya Kusufa Roni Alim , Halimatus Sakdiyah Siti 
Published: March 2022

LatarBelakang : Penularan virus corona diseluruh dunia semakin meningkat virus corona bersifat sensitif terhadap panas dan secara efektif dapat diinaktifkan oleh desinfektan mengandung klorin, pelarut lipid dengan suhu 56 derajat Celsius selama 30 menit. Pandemi Covid-19 banyak merugikan baik sektor perdagangan, informal maupun pariwisata. Siklus perputaran uang kacau karena banyak kerugian yang dialami pengusaha. Tujuan : Tujuan penelitian ini adalah untuk pengetahui akibat dari penyebaran Covid-19 terhadap pendapatan ekonomi masyarakat warung tenda Kecamatan Sukun Kelurahan Bandungrejosari Kabupaten Malang. Metode : Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan studi kasus (case study) Teknik pengumpulan data dilakukan dengan observasi, wawancara, dan dokumentasi. Hasil : Hasil dari penelitian adalah peran pemerintah dalam membantu kebutuhan pendapatan ekonomi masyarakat selama pandemic Covid-19 ini diketahui pemerintah memberikan bantuan antara lain BST sembako dan uang setiap bulan. Pemerintah menyikapi/memberikan solusi kepada masyarakat untuk memenuhi kebutuhan pendapatan selama Covid-19 dengan mensosialisasikan protocol kesehatan seperti anjuran pemerintah pusat dalam bentuk Satgas-Covid. Kesimpulan : Dampak pandemi sangat mempengaruhi semua sektor termasuk pendapatan ekonomi masyarakat rt3/rw2 Kelurahan Bandungrejosari, dari 8 responden hanya 1 yang menjawab adanya Covid-19 tidak mempengaruhi terhadap pendapatan masyarakat mereka dan 7 responden lainya bahwa Covid-19 sangat mempengaruhi pendapatan masyarakat, jadi peneliti menyimpulkan bahwa Covid-19 adalah faktor utama kekacauan terhadap penurunan pendapatan masyarakat.
Yıkımdan Mutlak Savaşa Bir Sonderweg: Carl Schmitt’in Politik Teolojisi
Authors: SARITAŞ İbrahim 
Published: March 2022

Antik dönemden ulus devlete kadar güçlü bir politik mecra bulan teoloji, Aydınlanma ve Fransız Devrimi’nin inşa ettiği seküler dönemde giderek zayıflar. Her ne kadar politik teoloji Almanya’da muhalif bir zeminde muhafazakâr ideoloji içerisinde dillendirilse de, muktedir olamama durumu modernin yaşadığı kriz anına kadar devam eder. Bu süreçte Carl Schmitt bu krizi fark eder ve bunu teolojinin politik olandan dışlandığı paradigmanın yansımaları olduğunu düşünür. Roma Katolik Kilisesi’nin temsil ettiği değerleri politik olan içerisinde yeniden ihya ederek inşa etmeyi düşündüğü politik teolojiyi bu krizin çözümü olarak görür ve bu doğrultuda devrimci muhafazakâr hissiyatın tam içerisinde modernin politik kavramlarını aşkın bir yapıya kavuşturur. Bu çalışma, bu bağlamda, Almanya özelinde politik teolojinin tarihsel seyrini ve Schmitt’in kendi teolojisini hangi temeller üzerine kurduğunu devrimci muhafazakârlığı göz önünde bulundurarak araştırmaktadır.
The Improving of B2 Aluminium Composite Panel Core Material with Eloxal Sludge by Using Recycling Process
Authors: ÖZCAN MERVE , KARACA BAHADIR , DEMİRCİ YUNUS EMRE , TUNCA BİLGEHAN , KUMRUOGLU LEVENT CENK 
Published: March 2022

In this study, it is aimed to improving core material by using eloxal sludge for production B2 composite panel. Optimal calcine eloxal sludge form was obtained at heat treatment regime with 700 C and 270 minutes. Also it was aimed to investigate possible agglomerate form in the polyurethane. The X-Ray Diffraction (XRD) and particle size analysis were performed to understand detailed structural analysis. The eloxal sludge was respectively doped with different percentage with 15 % and 6 % in the polyurethane for obtaining core material. . B2 composite panels were produced as 1250-1500 mm. The mechanical properties were measurement for different doped of eloxal sludge. The highest mechanical properties was obtained by using 15 % eloxal sludge has a 247 μm when it was observed that surface defects such as air bubbles. Also the thickness of the composite panel was measurement for all samples with 3.8 mm-4.2 mm.
INTERCORRÊNCIAS COM IMPLANTE EM SEIO MAXILAR: RELATO DE CASO.
Authors: Santos de Oliveira Miria , Coelho Paraguassu Éber 
Published: March 2022

O uso de implantes é uma temática que ainda está em processo de desenvolvimento no quesito discussão literária. Nos tempos atuais, com o avanço dos meios tecnológicos, houve mais procura e um maior interesse se percebeu em compreender sistemas de implantes. Uma realização e prática comum é instalar implantes na região posterior da maxila, porém, a área especifica trabalhada precisa ter um cuidado e uma atenção especial, pois com as particularidades existentes o surgimento de acidente é frequente, devido ser uma área frágil. Entre as possibilidades de acidentes que tendem a surgir, um deles é o deslocamento do implante para o interior do seio maxilar, no qual a permanência trará consequências como, por exemplo, sinusite aguda ou crônica, de tal forma o tratamento que é indicado é a remoção cirúrgica do mesmo. Neste artigo de relato: Paciente do gênero masculino, L.C.M, 40 anos de idade, compareceu a nossa clínica de especialização em implantodontia do GOE para remoção de um implante dentário no interior do seio maxilar esquerdo. O mesmo relatou que na reabertura depois de 05 meses, para colocação dos cicatrizadores, foi observado que o implante não tinha ossointegrado e acidentalmente o implante foi deslocado para o interior do seio maxilar. O Objetivo deste trabalho é analisar um processo de implantação por meio de uma intercorrência ocorrida na região posterior da maxila quando da instalação do implante, deslocado para o interior do seio maxilar e sua solução cirúrgica fora apresentada. Por fim, compreende-se que a região maxilar é uma região frágil e por ter baixa intensidade.
Phytochemical Characterization of Extracts from Fagraea Fragrans and Juglans Regia by GC-MS Analysis
Authors: Pillai Manoharan Karuppiah , Young David James 
Published: March 2022

Fagraea fragrans and Juglans regia have several therapeutic applications. The present study aimed to analyze the phytochemical compositions of a methanolic crude extract from the stem bark of F. fragrans and an oily liquid from a chloroform extract of seeds of J. regia. Approximately, 220 g of methanolic crude extract (yield = ca. 5%) was obtained from the stem bark of F. fragrans from hot-solvent extraction, and approximately, 45 g of chloroform oily liquid (yield = ca. 1.5%) was obtained from the seeds of J. regia by maceration technique. The phytochemical compositions of these two extracts were analyzed separately by injecting an aliquot of 1.0 μL solution of each extract prepared in hexane to a GC-MS instrument fitted with a DB-5 column of the dimension 50 m × 0.25 mm, i.d., 0.25 μm film thickness. The presence of fourteen components, including fragrant aldehydes and bioactive sterols, was identified in the methanolic crude extract and the presence of eight components, including fatty acids, fatty esters, and γ-tocopherol, was identified in the chloroform oily liquid. For the first time, we report the presence of γ-tocopherol (3.46%), n-hexanoic acid (1.26%), ethyl hexadecanoate (4.70%), ethyl oleate (6.59%), and a high content of ethyl linoleate (29.93%) in this chloroform oily liquid. From this study, we concluded that F. fragrans and J. regia have bioactive compounds of pharmaceutical importance. Therefore, these compounds can be extracted from these plants for therapeutic applications.
THE PROBLEM OF INTERFERENCE IN TEACHING RUSSIAN AS ANOTHER SLAVIC LANGUAGE
Authors: Голяк С.В. 
Published: March 2022

Статья посвящена проблеме интерференции при обучении русскому языку сербских студентов. Рассмотрены наиболее частотные ошибки на уровне лексики и морфологии, предложены задания для предупреждения интерференции. Подчеркнута важная роль сопоставительного (дифференциального) подхода к обучению.
The article is devoted to the problem of interference in teaching Russian to Serbian students. Frequency lexical and morphological mistakes are discussed. Eexercises to prevent interference are suggested. The important role of the confrontational (differential) approach is emphasized.
Penerapan Hukum Bisnis Sebagai Upaya Menstimulus Kinerja UMKM Dari Perspektif Marketing
Authors: Noor Tubagus Dicky Faldy Syahid , Nurendah Yulia , Suardy Weman 
Published: March 2022

Micro, Small, and Medium Enterprises are business activities that are able to expand employment opportunities and provide broad economic services to the community, and can play a role in the process of equity and increase people's income, encourage economic growth and play a role in realizing national stability. MSMEs need knowledge related to the legalization of designs, packaging, for example the procedures for registering products for Trademarks, Copyrights, Industrial Designs and brand disputes.

Keywords: Legality, Micro, Small, and Medium Enterprises, SWOT