bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of <i>f</i>(<i>R,T</i>) Gravity in Bianchi Type-V Dark Energy Model with Electromagnetic Field based on Lyra Geometry
Authors: Brahma B. P. , Dewri M. 
Published: September 2022

In this paper, a Bianchi type V Dark energy cosmological model scenario is studied with the electromagnetic field in Lyra based on f(R,T) gravity. The source of the magnetic field is along the x axis. Field equations found in Lyra geometry with electromagnetic field (F23 ≠ 0) in f(R,T) gravity, by choosing f(R~,T) = f1(R~) + f2(T) with f1(R~) + μR~ and f2(T) = μT. A hybrid scale factor discusses the physical and dynamical aspects of f(R,T) gravity.
Does the Solution to the Non-linear Diophantine Equation 3<sup>x</sup>+35<sup>y</sup>=Z<sup>2</sup> Exist?
Authors: Biswas D. 
Published: September 2022

This paper investigates the solutions (if any) of the Diophantine equation 3x + 35y = Z2, where , x, y, and z are whole numbers. Diophantine equations are drawing the attention of researchers in diversified fields over the years. These are equations that have more unknowns than a number of equations. Diophantine equations are found in cryptography, chemistry, trigonometry, astronomy, and abstract algebra. The absence of any generalized method by which each Diophantine equation can be solved is a challenge for researchers. In the present communication, it is found with the help of congruence theory and Catalan’s conjecture that the Diophantine equation 3x + 35y = Z2 has only two solutions of (x, y, z) as (1, 0, 2) and (0, 1, 6) in non-negative integers.
TRI KAYA PARISUDHA SEBAGAI LANDASAN KOMUNIKASI PENDIDIKAN DALAM MODERASI BERAGAMA
Authors: Yhani Putu Cory Chandra 
Published: September 2022

Abstrak
Interaksi masyarakat yang kini dalam terkikis dalam sebuah ideologi yang serba dangkal membuat konflik antar agama, suku, dan RAS. Pendalaman tentang ilmu pendidikan komunikasi masyarakat kini dikalahakan oleh isu-isu media sosial yang kebenarannya bisa diragukan. Terbesit dibenak pemerintah dalam menjaga harmonisasi keumatan dalam merawat sebuah kebhinekaan dalam sebuah sistem moderasi. Untuk menghasilkan data yang valid dan reliable, maka penelitian ini menggunakan metode penelitian kualitatif. Refrensi terkait sangat menunjang validitas suatu karya ilmiah, oleh karena itu digunakan juga teknik kepustakaan melalui penjajakan literature di google scholar. Konsep Hindu yang tertuang dalam ajaran Weda memberikan pemahaman tentang kerukunan, yang tertuang kedalam Tri Kaya Parisudha, bahwa pentingnya merawat kerukunan guna meminimalisir konflik yang terjadi belakangan ini. Tri Kaya Parisudha mengajarkan bahwa menjadi masyarakat harus berpikir, bermoral, dan berperilaku yang baik dan benar, sehingga menjadikan keharmonisan dalam keselarasan akan mengikat satu dengan yang lain.
PENERAPAN TEKNIK SCANNING UNTUK MENINGKATKAN KEMAMPUAN MEMBACA PEMAHAMAN PADA SISWA KELAS IV SD NEGERI 35 KOTA TERNATE
Authors: Abdullah Suhardi , Karim Kodrat Hi 
Published: September 2022

The objective of this research were to incerased students in reading comprehension at the 4th grade concluded that (1) highly speed reading without ignoring the students understanding, to gained the fact information, special fact and conclusion (2) the percentage of reading comprehension technique scanning in each cycles level of learning activity became high. The result of each cycle by the implementation scanning technique to improve speed reading showed at the first cycle was 4 (47,94%) students were achieved the KKM of 17 students, while the second cycle the students learning activities achieved 14 (76,95 %) of completeness of the students result. Based on the result of the implementation scanning technic using in speed reading concluded that this technic could be used as a strategy and technique in achieved the students reading competence and students developing skills in learning a language skill at SD Negeri 35 Kota Ternate and could be threaten in another elementary school level.
UPAYA MENINGKATKAN HASIL BELAJAR MEMBACA PERMULAAN MELALUI METODE KARTU SUKU KATA PADA SISWA KELAS I SDN 52 KOTA TERNATE
Authors: Marasabesy Anwar , Wahid Santi M.J. 
Published: September 2022

The expected objectives of this study are to investigate the use the Reading method with Syllable flash Card in Indonesian language learning in the first years of State elementary school and to find out students’ learning outcomes after using the Reading method with Syllable Card. This research is a Classroom Action Research (CAR). This research includes Planning, Implementation, Observation/Observation, and Reflection which are sequential steps in each cycle. There are 28 students of elementary school participated in this research. Data were collected through test. Data were analyzed using descriptive analysis. The results of data analysis in the first cycle shows that the number of students who completed was 6 students with an average number of 21.42% and who did not complete were 22 students with an average number of 78.57%. Meanwhile, in the second cycle, 21 students were completed with an average score of 75% and those who did not complete were 7 students with an average score of 25%. Thus, the observations in the first cycle to the second cycle show that the target of completeness, it means that this research was no longer continued in the next cycle.
Assessing equivalent and inverse change in genes between diverse experiments
Authors: Neums Lisa , Koestler Devin C. , Xia Qing , Hu Jinxiang , Patel Shachi , Bell-Glenn Shelby , Pei Dong , Zhang Bo , Boyd Samuel , Chalise Prabhakar , Thompson Jeffrey A. 
Published: September 2022

Background: It is important to identify when two exposures impact a molecular marker (e.g., a gene’s expression) in similar ways, for example, to learn that a new drug has a similar effect to an existing drug. Currently, statistically robust approaches for making comparisons of equivalence of effect sizes obtained from two independently run treatment vs. control comparisons have not been developed.Results: Here, we propose two approaches for evaluating the question of equivalence between effect sizes of two independent studies: a bootstrap test of the Equivalent Change Index (ECI), which we previously developed, and performing Two One-Sided t-Tests (TOST) on the difference in log-fold changes directly. The ECI of a gene is computed by taking the ratio of the effect size estimates obtained from the two different studies, weighted by the maximum of the two p-values and giving it a sign indicating if the effects are in the same or opposite directions, whereas TOST is a test of whether the difference in log-fold changes lies outside a region of equivalence. We used a series of simulation studies to compare the two tests on the basis of sensitivity, specificity, balanced accuracy, and F1-score. We found that TOST is not efficient for identifying equivalently changed gene expression values (F1-score = 0) because it is too conservative, while the ECI bootstrap test shows good performance (F1-score = 0.95). Furthermore, applying the ECI bootstrap test and TOST to publicly available microarray expression data from pancreatic cancer showed that, while TOST was not able to identify any equivalently or inversely changed genes, the ECI bootstrap test identified genes associated with pancreatic cancer. Additionally, when investigating publicly available RNAseq data of smoking vs. vaping, no equivalently changed genes were identified by TOST, but ECI bootstrap test identified genes associated with smoking.Conclusion: A bootstrap test of the ECI is a promising new statistical approach for determining if two diverse studies show similarity in the differential expression of genes and can help to identify genes which are similarly influenced by a specific treatment or exposure. The R package for the ECI bootstrap test is available at https://github.com/Hecate08/ECIbootstrap.
Hydrogenolysis of glycerol over TiO2-supported Pt-WOx catalysts: Effects of the TiO2 crystal phase and WOx loading
Authors: Wang Yaju , Zhou Zhiming , Wang Chao , Zhao Leihong , Xia Qineng 
Published: September 2022

The selective hydrogenolysis of glycerol to 1,3-propanediol (1,3-PDO) with high added value is attraction but challenging. Pt-WOx-based catalysts have been extensively studied in the selective hydrogenolysis of glycerol. The catalyst support and the physicochemical state of WOx play important roles on this reaction. In this paper, Pt-WOx catalysts supported on TiO2 with different crystal forms were prepared and studied for their catalytic performance in hydrogenolysis of glycerol. It was observed that the catalytic performance of anatase-type (A-type) TiO2-supported catalyst (Pt/W/A-Ti) is much better than that of the rutile-type (R-type) TiO2 catalyst (Pt/W/R-Ti) due to its higher stability. Furthermore, the influence of W loading amount and state were thoroughly investigated for the Pt/W/A-Ti catalysts, and Pt/W/A-TiO2 with 5 wt% loading of WOx achieved the best catalytic performance (100% conversion of glycerol and 41% yield of 1,3-PDO under the optimal reaction conditions), owing to the suitable WOx domains and high dispersion of W species, as evidenced by XRD patterns and TEM images. Mechanism study by in-situ DRIFTS experiments indicated that glycerol was first converted to 3-hydroxypropanal and then converted to 1,3-PDO through subsequent reactions.
Resonant photoacoustic spectrometer enhanced by multipass absorption for detecting atmospheric CH4 at the ppb-level
Authors: Liu Qiang , Sun Yi , Qiu Xuanbing , Guo Guqing , Li Lin , Gong Ting , Li Chuanliang 
Published: September 2022

A resonant photoacoustic spectrometer (PAS) was developed for detecting trace atmospheric CH4. The sensitivity of the PAS was significantly increased via a Herriott-type multipass cell with a beam pattern concentrated in the cavity. The effective optical pathlength of the PAS can be optimized to 6.8 m with 34 reflections and a diameter of 6 mm. A distributed feedback diode laser at 1,653 nm was employed as the light source, and wavelength modulation spectroscopy was used for the 2nd harmonic signal to reduce the noise of the system. The resonant cell of PA and optimal modulation frequency were obtained by varying the measurements. In comparison with a single path, the sensitivity of the multipass strategy was improved 13 times. To evaluate the long-term stability and minimum detection limit (MDL) of the system, an Allan variance analysis was performed, and the analysis illustrated that the MDL accomplished 116 ppb at an average time of 84 s. The system was utilized for 2 days test campaign to validate the feasibility and robustness of the sensor. The system provides a promising technique for online monitoring of greenhouse gasses.
A mitochondria-targeted nano-platform for pancreatic cancer therapy
Authors: Tan Xiaoke , Zhu Xin , Xu Duanjie , Shi Yanmei , Wang Zhenzhen , Cao Mingzhuo , Hu Kai , Zhao Lingzhou , Zhao Junwei , Miao Mingsan , Zeng Huahui , Wu Xiangxiang 
Published: September 2022

Liposome is a conventional drug delivery system which has been widely used in the pharmacy field. However, its applications are greatly restricted in clinical practice by the disadvantages of cholesterol and nonselective distribution. Herein, a novel platform for anti-tumor drug delivery was developed by incorporating an amphiphilic stachydrine-octadecane conjugate (SS) as the mitochondria-targeting molecule onto the triptolide-liposome surfaces (SS-TP LPs). The polyethylene glycol (PEG) and the suitable particle size (about 133 nm) of liposomes facilitated their stabilities, the long half-life in blood and the escape from the rapid elimination. The SS-TP LPs were internalized and accumulated into the mitochondria of cancer cells in a time-dependent manner, followed by triggering permeabilization of the mitochondrial outer membrane by inhibiting Bcl-2, and then further caused greater cancer cell death via releasing cytochrome C and initiating a cascade of caspase 3 reactions. In the Pan02 tumor-bearing mice, the SS-TP LPs showed significant efficacy in inhibiting tumor growth and reducing tumor size but synchronously exhibited specific mitochondria-targeting and much lower subacute toxicity compared with the free TP and TP LPs. Our study suggests that SS-TP LPs can be a promising anticancer drug delivery system for mitochondria-targeted therapy in pancreatic cancer.
Plasma trimethylamine-N-oxide, its precursors and risk of cardiovascular events in patients with acute coronary syndrome: Mediating effects of renal function
Authors: Sanchez-Gimenez Raul , Peiró Óscar M. , Bonet Gil , Carrasquer Anna , Fragkiadakis Georgios A. , Bulló Mònica , Papandreou Christopher , Bardaji Alfredo 
Published: September 2022

AimsTo examine associations of the gut microbial metabolite trimethylamine-N-oxide (TMAO) and its precursors with risk of cardiovascular events in acute coronary syndrome (ACS), and determine whether these associations were mediated by renal function.MethodsIn this prospective cohort study, we included 309 patients with ACS. During a mean follow-up of 6.7 years, 131 patients developed major adverse cardiovascular events (MACE) (myocardial infarction, hospitalization for heart failure, and all-cause mortality). Plasma concentrations of TMAO, trimethylamine (TMA), choline, betaine, dimethylglycine and L-carnitine were profiled by liquid chromatography tandem mass spectrometry. Hazard ratios were estimated with multivariable Cox regression models. The mediating role of estimated glomerular filtration rate (eGFR) was tested under a counterfactual framework.ResultsAfter adjustment for traditional cardiovascular risk factors and medications, participants in the highest tertile vs. the lowest tertile of baseline TMAO and dimethylglycine concentrations had a higher risk of MACE [(HR: 1.83; 95% CI: 1.08, 3.09) and (HR: 2.26; 95% CI: 1.17, 3.99), respectively]. However, with regards to TMAO these associations were no longer significant, whereas for dimethylglycine, the associations were attenuated after additional adjustment for eGFR. eGFR mediated the associations of TMAO (58%) and dimethylglycine (32%) with MACE incidence. The associations between dimethylglycine and incident MACE were confirmed in an internal validation. No significant associations were found for TMA, choline, betaine and L-carnitine.ConclusionThese findings suggest that renal function may be a key mediator in the association of plasma TMAO with the development of cardiovascular events after ACS. The present findings also support a role of dimethylglycine in the pathogenesis of MACE, which may be mediated, at least partially, by renal function.
15-Deoxy-Delta-12,14-prostaglandin J2 modulates pro-labour and pro-inflammatory responses in human myocytes, vaginal and amnion epithelial cells
Authors: Rasheed Zahirrah BM. , Lee Yun S. , Kim Sung H. , Teoh Tg , MacIntyre David A. , Bennett Phillip R. , Sykes Lynne 
Published: September 2022

BackgroundPrematurity is the leading cause of childhood death under the age of five. The aetiology of preterm birth is multifactorial; however, inflammation and infection are the most common causal factors, supporting a potential role for immunomodulation as a therapeutic strategy. 15-Deoxy-Delta-12,14-prostaglandin J2 (15dPGJ2) is an anti-inflammatory prostaglandin and has been shown to delay lipopolysaccharide (LPS) induced preterm labour in mice and improve pup survival. This study explores the immunomodulatory effect of 15dPGJ2 on the transcription factors NF-κB and AP-1, pro-inflammatory cytokines, and contraction associated proteins in human cultured myocytes, vaginal epithelial cell line (VECs) and primary amnion epithelial cells (AECs).MethodsCells were pre-incubated with 32µM of 15dPGJ2 and stimulated with 1ng/mL of IL-1β as an in vitro model of inflammation. Western immunoblotting was used to detect phosphorylated p-65 and phosphorylated c-Jun as markers of NF-κB and AP-1 activation, respectively. mRNA expression of the pro-inflammatory cytokines IL-6, IL-8, and TNF-α was examined, and protein expression of COX-2 and PGE2 were detected by western immunoblotting and ELISA respectively. Myometrial contractility was examined ex-vivo using a myograph.Results15dPGJ2 inhibited IL-1β-induced activation of NF-κB and AP-1, and expression of IL-6, IL-8, TNF-α, COX-2 and PGE2 in myocytes, with no effect on myometrial contractility or cell viability. Despite inhibiting IL-1β-induced activation of NF-κB, expression of IL-6, TNF-α, and COX-2, 15dPGJ2 led to activation of AP-1, increased production of PGE2 and increased cell death in VECs and AECs.ConclusionWe conclude that 15dPGJ2 has differential effects on inflammatory modulation depending on cell type and is therefore unlikely to be a useful therapeutic agent for the prevention of preterm birth.
Diagnostic accuracy and validation of 18F-fluorodeoxyglucose positron emission tomography scores in a large cohort of patients with polymyalgia rheumatica
Authors: Moreel Lien , Boeckxstaens Lennert , Betrains Albrecht , Van Hemelen Maarten , Vanderschueren Steven , Van Laere Koen , Blockmans Daniel 
Published: September 2022

BackgroundSeveral studies have shown that 18F-FDG PET may contribute to the diagnosis of polymyalgia rheumatica (PMR). Previously, we developed a composite PET score called the Leuven score, which was recently adapted to the more concise Leuven/Groningen score by van der Geest et al. The aim of this study is to validate and compare the diagnostic accuracy and cut-off points of both scores in a large cohort of PMR patients.MethodsPatients with a possible clinical diagnosis of PMR and a PET scan prior to the initiation of glucocorticoids between 2003 and 2020 were included retrospectively. The gold standard for the diagnosis of PMR was the judgment of two experienced clinicians after a follow-up of at least 6 months. FDG uptake was scored visually in 12 articular regions (scores 0–2) and a total skeletal score was calculated by summing the individual scores (maximum of 24 for the Leuven score and 14 for the Leuven/Groningen score). Receiver operating characteristic (ROC) analysis and the Youden index were used to determine the diagnostic accuracy and optimal cut-off points.ResultsA total of 162 patients with PMR and 83 control patients were included. Both PET scores showed high diagnostic accuracy in the ROC analysis (area under the curve 0.986 and 0.980, respectively). The Leuven Score provided a sensitivity of 91.4%, specificity of 97.6% and accuracy of 93.5% at its predefined cut-off point of 16. With the newly determined cut-off point of 12 the sensitivity was 98.8%, the specificity 95.2% and the accuracy 97.6%. The Leuven/Groningen score had a sensitivity, specificity and accuracy of 93.2%, 95.2%, and 93.9%, respectively, with the pre-specified cut-off point of 8, and 96.9%, 92.8%, and 95.5% with the optimal cut-off point of 7.ConclusionThe original Leuven score and the simplified Leuven/Groningen score both had excellent diagnostic accuracy. The latter may be easier to apply in clinical practice.
Randomized placebo-controlled double-blind phase II study of zaltoprofen for patients with diffuse-type and unresectable localized tenosynovial giant cell tumors: The REALIZE study
Authors: Takeuchi Akihiko , Endo Makoto , Kawai Akira , Nishida Yoshihiro , Terauchi Ryu , Matsumine Akihiko , Aiba Hisaki , Nakamura Tomoki , Tandai Susumu , Ozaki Toshifumi , Hoshi Manabu , Kayano Daiki , Okuda Miho , Yamamoto Norio , Hayashi Katsuhiro , Miwa Shinji , Igarashi Kentaro , Yoshimura Kenichi , Nomura Akihiro , Murayama Toshinori , Tsuchiya Hiroyuki 
Published: September 2022

BackgroundA tenosynovial giant cell tumor (TGCT) is a locally aggressive benign neoplasm arising from intra- or extra-articular tissue, categorized as localized (L-TGCT, solitary lesion) and diffuse (D-TGCT, multiple lesions) TGCT. Surgical excision is the mainstay of the treatment, and a high local recurrence rate of approximately 50% has been reported. We focused on zaltoprofen, a nonsteroidal anti-inflammatory drug that can activate peroxisome proliferator-activated receptor gamma (PPARγ) and inhibit the proliferation of TGCT stromal cells. Therefore, we conducted a randomized trial to evaluate the safety and effectiveness of zaltoprofen in patients with D-TGCTs or unresectable L-TGCTs.MethodsThis randomized, placebo-controlled, double-blind, multicenter trial evaluated the safety and efficacy of zaltoprofen. In the treatment group, zaltoprofen (480 mg/day) was administered for 48 weeks; the placebo group received similar dosages without zaltoprofen. The primary outcome was progression-free rate (PFR) 48 weeks after treatment administration. Disease progression was defined as the following conditions requiring surgical intervention: 1) repetitive joint swelling due to hemorrhage, 2) joint range of motion limitation, 3) invasion of the adjacent cartilage or bone, 4) severe joint space narrowing, and 5) increased tumor size (target lesion).ResultsForty-one patients were allocated to the zaltoprofen (n=21) or placebo (n=20) groups. The PFR was not significant between the zaltoprofen group and the placebo group at 48 weeks (84.0% and 90.0%, respectively; p=0.619). The mean Japanese Orthopedic Association knee score significantly improved from baseline to week 48 in the zaltoprofen group (85.38 versus 93.75, p=0.027). There was a significant difference between the values at 48 weeks of placebo and zaltoprofen group (p=0.014). One severe adverse event (grade 3 hypertension) was observed in the zaltoprofen group.DiscussionThis is the first study to evaluate the efficacy and safety of zaltoprofen in patients with TGCT. No significant differences in PFR were observed between the groups at 48 weeks. Physical function significantly improved after zaltoprofen treatment. The safety profile of zaltoprofen was acceptable. This less invasive and safer treatment with zaltoprofen, compared to surgical removal, could be justified as a novel approach to treating TGCT. Further analysis of long-term administration of zaltoprofen should be considered in future studies.Clinical Trial RegistrationUniversity Hospital Medical Information Network Clinical Trials Registry, identifier (UMIN000025901).