bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of Chemical Composition and Unveiling the Phytopharmaceutical Potentials of Essential Oil from Fossilized Resin of Pinus succinefera
Authors: Jha Vikas , Shaikh Mohd Aslam , Devkar Sakshi , Patel Reetikesh , Walunj Shraddha , Rai Diksha , Koli Joshua , Dhamapurkar Vrushali , Jain Tisha , Jadhav Namrata , Marick Arpita , Dhopeshwarkar Divya 
Published: July 2022

Background: Most of the plant natural flora contributes significantly to medicinal benefits. To address the shortcoming usage of synthetic drugs, natural products are in demand which offer a broad spectrum of activities with negligible side effects. Pinus succinefera is a fossilized resin from coniferous woods that belongs to the genus Pinus of the Pinaceae family and is widely known as Amber. The present study explores the physiochemical properties and broad spectrum of biological activities of the essential oil.
Method: The essential oil obtained using the hydro-distillation process, and chemical composition was examined by Gas Chromatography-Mass Spectrometric analysis as well as the functional groups present in the essential oil were determined using Fourier Transform Infrared Spectrometry. Thermal characterisation was performed using the Thermo Gravimetric Analysis and Differential Scanning Calorimetry. The antimicrobial potential of the essential oil was evaluated against different microorganisms meanwhile antimalarial activity against Plasmodium falciparum was examined. The free radical scavenging capability of the essential oil was assessed using 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) reagent. High-performance thin-layer chromatography was used to examine the qualitative components of the essential oil.
Results: The Gas Chromatography-Mass Spectrometric analysis profile indicated 5 major compounds in the essential oil, which consisted of 99% of the total oil. The thermal analysis of the essential oil established thermal stability. The essential oil showed moderate antioxidant and a moderate to significant potential was observed against microbial species including Plasmodium falciparum. In High-performance thin-layer chromatography five bands of essential oil components with Retention factor ranging from 0.2 to 0.7 at 254nm were represented.
Conclusion: The results indicated that the essential oil obtained from Pinus succinefera has the potential to be used in the pharmaceutical industry to manufacture medicinal substances, as well as it can show a significant capability in other domains.
Antioxidant Activities of Aqueous Leaf Extract of Anacardium occidentale (Cashew) on Lead Acetate-Induced Cerebellar Toxicity in Wistar Rats
Authors: Oviosun Ezinne C. , Anyanwu G. E. , Esom E. A. , Nweze S. O. 
Published: July 2022

Aim: The aim of the present study was to investigate the antioxidant effect of aqueous leaves extract of Anacardium occidentale (A.O) on lead-induced toxicity in the cerebellum of wistar rats.
Methods: Thirty wistar rats were randomly divided into six groups of five rats each. Group A: Normal control received 0.5ml normal saline; group B received 50mg/kg body weight (bwt) lead acetate (Pb) only (28 days); groups C and D: 150mg/kg bwt and 300mg/kg bwt of A.O respectively for 14 days and 50mg/kg bwt of Pb next 14 days; group E: 150 mg/kg bwtA.O and 50 mg/kg bwt Pb (28 days); group F: 300mg/kg bwt A.O and 50 mg/kg bwt Pb (28 days). At the end of the experiment, animals were sacrificed by cervical dislocation. One hemisphere of the cerebellum was homogenized for estimation of tissue Superoxide Dismutase (SOD), Glutathione peroxidase (GPx) and Malondialdehyde (MDA) levels, and the second hemisphere was processed for histological studies.
Results: Histological examination of lead only treated groups, showed alterations in cerebellar architecture. Biochemical estimations showed significant decrease in SOD, GPx levels (P=.03 and .04 respectively) and significant increase in MDA levels (P=.04), indicative of oxidative stress. Pretreatment and co-treatment with A.O showed dose dependent preservation of cerebellar architecture, significant increase of antioxidant parameters (SOD and GPx) (P=.03) and significant (P=.02) decrease in MDA.
Conclusion: This study suggests that Anacardium occidentale especially at a higher dose (300mg/kg) exhibits antioxidant activities against lead-induced oxidative stress in the cerebellum of rats.
Demography of cape petrels in response to environmental changes
Authors: Sauser Christophe , Delord Karine , Barbraud Christophe 
Published: July 2022

AbstractPredicting the responses of populations in changing environments is an important task for ecologists. Understanding the population dynamics of high‐latitude breeding species is critical given the particularly rapid environmental changes that occur in these regions. Using long‐term mark–resighting data acquired over 53‐years in Pointe Géologie, Terre Adélie, Antarctica, we estimated age‐specific demographic parameters and evaluated the effect of the environment on survival of a poorly known species, the cape petrelDaption capense. We then modeled the dynamics of this population using a life‐history model and performed prospective and retrospective analyses to estimate the sensitivity of the population growth rate to demographic parameters, and to quantify their relative contribution. Survival of cape petrel increased with age, being 0.610 (±0.193) for juveniles, 0.739 (±0.158) for individuals from 2 to 4, and 0.920 (±0.031) for older individuals. Minimum age at first reproduction was 3 years old, the age at which all birds were recruited was 14 years, and mean age at first reproduction was 9.05 (±2.06) years. Adult survival increased over time and was positively correlated with the southern annular mode (SAM). The stochastic population growth rate was estimated at 1.019, and adult survival over age 5 made the largest contribution to variance of the population growth rate. Sensitivity analyses revealed that population regulation was mainly driven by the SAM. Our results suggest that despite the decrease in breeding success, the population of cape petrels at Pointe Géologie increased due to the increase in immature and adult survival.
Linker Unit Modulation of Polymer Acceptors Enables Highly Efficient Air‐Processed All‐Polymer Solar Cells
Authors: Kim Ha Kyung , Yu Han , Pan Mingao , Shi Xiaoyu , Zhao Heng , Qi Zhenyu , Liu Wei , Ma Wei , Yan He , Chen Shangshang 
Published: July 2022

AbstractA group of regioregular polymer acceptors is synthesized by polymerizing Y6 moieties with different linker units including thiophene, vinylene, 2,2’‐bithiophene, and thieno[3,2‐b]thiophene, and their optoelectrical properties and photovoltaic performances are studied systematically. It is found that the linker units have significant impacts on the backbone planarity, conjugation, and hence optoelectrical properties of polymer acceptors. The vinylene‐based PYF‐V‐o polymer shows a smaller dihedral angle between the end groups and vinylene units and a more rigid polymer backbone, thus affording bathochromic absorption and better electron‐transporting capacity. As a result, the PM6:PYF‐V‐o based all‐polymer solar cells (all‐PSCs) are able to achieve the highest power conversion efficiency of 16.4% with an unprecedented small voltage loss of 0.49 V. Moreover, the PM6:PYF‐V‐o blend exhibits good resistance to environmental stressors and the air‐processed PM6:PYF‐V‐o cells can still maintain a high efficiency of 16.1%, which is the best air‐processed all‐PSC efficiency reported to date. This study provides the structural‐property guidance that can be used to facilitate the development of polymer acceptors for all‐PSCs.
Effective hemostasis by preperitoneal pelvic packing for common iliac vein injury without pelvic fracture in severe blunt trauma: a case report
Authors: Fujita Akihiro , Nakatsutsumi Keita , Takahashi Tatsuaki , Suzuki Tensei , Nakashima Choko , Ito Kei , Endo Akira , Otomo Yasuhiro 
Published: July 2022

BackgroundA common iliac vein injury in the absence of pelvic fractures due to blunt trauma is rare, with no treatment strategy established.Case PresentationA 48‐year‐old man, who was injured in a dumbwaiter accident, presented to the hospital with hemorrhagic shock. Computed tomography (CT) revealed active bleeding from the intercostal and hepatic arteries as well as the left common iliac vein. No pelvic fracture was noted. Preperitoneal pelvic packing was performed for the left common iliac vein injury as a damage control surgery. After the operation, endovascular embolization was performed to address the arterial bleeding. The patient became hemodynamically stable, and follow‐up CT showed no signs of bleeding. The packing gauze was removed 3 days after the admission. The patient was discharged without complications.ConclusionPreperitoneal pelvic packing provided temporary hemostasis in a hemodynamically unstable patient with common iliac vein injury but with no pelvic fractures.
Third‐Generation Covalent TMP‐Tag for Fast Labeling and Multiplexed Imaging of Cellular Proteins
Authors: Mo Jiaming , Chen Jingting , Shi Yabo , Sun Jingfu , Wu Yunxiang , Liu Tianyan , Zhang Junwei , Zheng Yu , Li Yulong , Chen Zhixing 
Published: July 2022

AbstractSelf‐labeling protein tags can introduce advanced molecular motifs to specific cellular proteins. Here we introduce the third‐generation covalent TMP‐tag (TMP‐tag3) and showcase its comparison with HaloTag and SNAP‐tag. TMP‐tag3 is based on a proximity‐induced covalent Michael addition between an engineered Cys of E. coli dihydrofolate reductase (eDHFR) and optimized trimethoprim (TMP)–acrylamide conjugates with minimal linkers. Compared to previous versions, the TMP‐tag3 features an enhanced permeability when conjugated to fluorogenic spirocyclic rhodamines. As a small protein, the 18‐kD eDHFR is advantageous in tagging selected mitochondrial proteins which are less compatible with bulkier HaloTag fusions. The proximal N−C termini of eDHFR also enable facile insertion into various protein loops. TMP‐tag3, HaloTag, and SNAP‐tag are orthogonal to each other, collectively forming a toolbox for multiplexed live‐cell imaging of cellular proteins under fluorescence nanoscopy.
Molecular Engineering of Sulfur‐Bridged Polycyclic Emitters Towards Tunable TADF and RTP Electroluminescence
Authors: Li Mengke , Xie Wentao , Cai Xinyi , Peng Xiaomei , Liu Kunkun , Gu Qing , Zhou Jiadong , Qiu Weidong , Chen Zijian , Gan Yiyang , Su Shi‐Jian 
Published: July 2022

AbstractHighly efficient organic thermally activated delayed fluorescence (TADF) and room‐temperature phosphorescence (RTP) emitters for organic light‐emitting diodes (OLEDs) generally consist of a twisted donor–acceptor skeleton with aromatic amine donors. Herein, through introducing sulfur atoms into isomeric pentaphene and pentacene frameworks, we demonstrate a set of polycyclic luminophores exhibiting efficient TADF and RTP characters. The incorporation of sulfur atoms confirms a folded molecular plane, while intensifies singlet–triplet spin‐orbit coupling. Further, the isomeric effect has a significant effect on the electronic structure of excited state, giving rise to the investigated compounds tunable luminescence mechanisms of TADF and RTP. With efficient triplet harvesting ability, maximum external quantum efficiencies up to 25.1 % and 8.7 % are achieved for the corresponding TADF and RTP OLEDs, verifying the great potential of sulfur‐bridged frameworks for highly efficient devices.
Phenacyl Bromide as a Single‐Component Photoinitiator: Photoinduced Step‐Growth Polymerization ofN‐Methylpyrrole andN‐Methylindole
Authors: Kocaarslan Azra , Kaya Kerem , Jockusch Steffen , Yagci Yusuf 
Published: July 2022

AbstractThe synthesis of step‐growth polymers by photoinduced methods is a challenging issue in synthetic chemistry. Here, we report a single component near UV responsive photopolymerization system for step‐growth polymerization ofN‐methylpyrrole (MPyr) andN‐methylindole (MIn) by using phenacyl bromide (PAB). The obtained high molecular weight conjugated polymers were characterized by spectral and chromatographic methods. Detailed laser flash photolysis and spectroscopic studies revealed that polymerization proceeds by successive photoinduced cleavage of PAB followed by electron transfer, proton release and coupling processes. After photolysis, chain growth continues also in daylight or dark by acidic oxidation. The structural features of the polymers were investigated. PAB single component photoinitiator enables an efficient, rapid, room temperature step‐growth polymerization process of MPyr and MIn that can be applied to other conjugated monomers.
Synthesis of dual‐stimuli‐responsive polyurethane shape memory nanocomposites incorporating isocyanate‐functionalized Fe3O4 nanoparticles
Authors: Babaie Amin , Rezaei Mostafa , Razzaghi Donya , Roghani‐Mamaqani Hossein 
Published: July 2022

AbstractThermally and magnetically stimulated shape memory polyurethane (PU) nanocomposites were synthesized for intravascular stent applications. For this end, Fe3O4 magnetic nanoparticles (MNPs) were modified with octadecyl isocyanate (OD) to increase their affinity with the PU matrix by formation of the covalent urea linkages. The results showed that the OD‐grafted MNPs were replaced instead of carbonyl groups of polycaprolactone (PCL) soft segments in hydrogen bond formation with the urethane linkages. This led to higher phase separation degrees among the soft and hard phases, thereby PCL chains could reveal higher crystallization potential. Mechanical studies showed that the nanocomposites had high mechanical strength, Young's modulus, and elongation at break, which improve their practical applications. The nanocomposites showed thermo‐responsive shape memory behavior with a high shape recovery and shape fixity ratios due to the presence of the crystallizable PCL segments. The nanocomposite containing 10 wt% of the OD‐grafted MNPs could recover its original shape (during 90s) in a relatively weak alternating magnetic field (350 kHz and 12.9 kA/m). These results indicated that the prepared nanocomposites could be used to normalize the narrowed blood vessels through the remotely and magnetically‐controllable restricted shape recovery process.
Convergence on iterative learning control of Hilfer fractional impulsive evolution equations
Authors: Raghavan Divya , Nagarajan Sukavanam 
Published: July 2022

AbstractIn this paper, impulsive fractional differential equations with Hilfer fractional derivatives of order
and type
is considered. Convergence analysis of
‐type and
‐type open‐loop iterative learning scheme is studied in the sense of
‐norm. Examples are provided to explain the theory developed.
Boosting Sodium Storage of Titanium Oxide through Homojunction Design
Authors: Zhang Maiji , Wang Zhenzhu , Ni Jiangfeng , Li Liang 
Published: July 2022

AbstractSodium‐ion batteries are regarded as the energy storage of choice for large‐scale applications due to their ample resource and low cost. However, their practical application has been largely retarded by the lack of efficient and stable anodes capable of storing a large amount of Na+ ions reversibly. In this work, we introduce the concept of homojunction into the design of sodium anodes by growing TiO2 nanowires composed of both anatase and bronze intimately interwoven. The interplay between the two phases brings abundant boundaries and interfaces, which drastically increase the storage sites and facilitate the transport of Na+ ions. As a result, it reveals robust Na+ storage, affording a capability of 140 mAh g−1 at a high rate of 20 C and retaining 85 % of the initial capacity after 3000 cycles at 5 C. Furthermore, the practice of TiO2 homojunction has been explored by pairing it with Na3V2(PO4)2O2F cathode, thereby demonstrating the potential of designing homojunction as a promising materials strategy in rechargeable batteries.
The impact of locomotion techniques on user experience on virtual reality on light of different scene contrasts
Authors: Agić Ana , Mandić Lidija , Skorin‐Kapov Lea 
Published: July 2022

AbstractLocomotion techniques are an important part of the virtual reality (VR) experience, as they enable a means of movement within simulated computer graphics. Studies have shown that locomotion techniques cause unpleasant effects related to cybersickness. In this article, we report on the results of a user study (N = 29) aimed to investigate and compare three types of locomotion techniques in VR in terms of their impact on cybersickness. The different locomotion techniques are tested in two different contrast scene settings, daytime and nighttime, to further explore the potential impact of scene contrast adjustments. For the evaluation of cybersickness, we used a questionnaire to obtain subjective ratings, and heart rate monitoring as an objective metric. Results show that a linear movement locomotion technique provokes the highest level of cybersickness, and that women have a higher heart rate as compared to men when navigating and interacting in a VR scene. Regarding the influence of scene contrast, results showed that scenes with daylight were better suited to participants in almost all tested scenarios. In addition to reported findings related to locomotion techniques and the impact on cybersickness, we highlight that a key contribution is the utilized test methodology.
Lectin Drug Conjugates Targeting High Mannose N‐Glycans
Authors: Kurhade Suresh E. , Ross Patrick , Gao Fei Philip , Farrell Mark P. 
Published: July 2022

AbstractCancer‐associated alterations to glycosylation have been shown to aid cancer development and progression. An increased abundance of high mannose N‐glycans has been observed in several cancers. Here, we describe the preparation of lectin drug conjugates (LDCs) that permit toxin delivery to cancer cells presenting high mannose N‐glycans. Additionally, we demonstrate that cancer cells presenting low levels of high mannose N‐glycans can be rendered sensitive to the LDCs by co‐treatment with a type I mannosidase inhibitor. Our findings establish that an increased abundance of high mannose N‐glycans in the glycocalyx of cancer cells can be leveraged to enable toxin delivery.
New Far‐Red and Near‐Infrared Fluorescent Phycobiliproteins with Excellent Brightness and Photostability
Authors: Hou Ya‐Nan , Ding Wen‐Long , Jiang Xiang‐Xiang , Hu Ji‐Ling , Tan Zi‐Zhu , Zhao Kai‐Hong 
Published: July 2022

AbstractFar‐red and near‐infrared fluorescent proteins can be used as fluorescence biomarkers in the region of maximal transmission of most tissues and facilitate multiplexing. Recently, we reported the generation and properties of far‐red and near‐infrared fluorescent phycobiliproteins, termed BeiDou Fluorescent Proteins (BDFPs), which can covalently bind the more readily accessible biliverdin. Far‐red BDFPs maximally fluoresce at ∼670 nm, while near‐infrared BDFPs fluoresce at ∼710 nm. In this work, we molecularly evolved BDFPs as follows: (a) mutations L58Q, S68R and M81K of BDFPs, which can maximally enhance the effective brightness in vivo by 350 %; (b) minimization and monomerization of far‐red BDFPs 2.1, 2.2, 2.3, and near‐infrared BDFPs 2.4, 2.5 and 2.6. These newly developed BDFPs are remarkably brighter than the formerly reported far‐red and near‐infrared fluorescent proteins. Their advantages are demonstrated by biolabeling in mammalian cells using super‐resolution microscopy.
Validation of a simplified intravascular ultrasound core lab analysis method in stented coronary arteries
Authors: Neleman Tara , Khachabi Jamal , Jonker Hans , Rademaker‐Havinga Tessa , Spitzer Ernest , Daemen Joost 
Published: July 2022

AbstractObjectivesTo validate a simplified core laboratory intravascular ultrasound (IVUS) analysis method based on frames with visually determined minimal lumen areas (MLAs) as compared with a comprehensive (per frame) analysis method.BackgroundIVUS‐guided percutaneous coronary intervention has proven to be superior to angiography‐guided stenting. In clinical practice, cross‐sections with visually determined MLA are measured to determine lesion severity or minimal stent area (MSA), however, its accuracy has not been compared with a comprehensive per frame analysis method.MethodsA total of 50 stented coronary segments of anonymized core lab datasets were analyzed using a comprehensive analysis method and reanalyzed by two core lab analysts using the simplified method including a maximum of seven frames to be analyzed (the visually determined MSA, the first and last frame, and the MLA of each reference segment). The main parameters of interest were MSA, MLA in the reference segments, and plaque burden.ResultsThe simplified method showed moderate agreement for measurement of the proximal MLA (7.51 ± 2.52 vs. 6.32 ± 1.88 mm2, intraclass correlation coefficient [ICC] = 0.73), good agreement for the distal MLA (5.41 ± 1.85 vs. 5.11 ± 1.38 mm2, ICC = 0.84) and plaque burden proximal (0.49 ± 0.12 vs. 0.50 ± 0.11, ICC = 0.88), and excellent agreement for the MSA (5.35 ± 1.05 vs. 5.32 ± 0.99 mm2, ICC = 0.94) and plaque burden distal (0.47 ± 0.14 vs. 0.47 ± 0.12, ICC = 0.92), when compared with the comprehensive analysis method. Inter‐ and intraobserver analysis revealed good‐to‐excellent agreement for all parameters.ConclusionsMeasuring poststenting IVUS cross‐sections with visually determined MLAs by experienced core lab analysts is an accurate and reproducible method to identify MLAs.
An azoospermic male with a novel chromosome 46, XX, der(15)t(Y; 15)(p11.3; p12)
Authors: Wu Jiebin , Hu Guanli , Zhai Jingfang , Han Conghui , Li Zhenbei 
Published: July 2022

AbstractMale individuals with a 46, XX karyotype are commonly diagnosed with 46, XX male sex reversal syndrome, one of the rarest sex chromosomal anomalies. In this case, we report a rare XX male with Y‐specific DNA sequences located near the end of chromosome 15 p‐arm, which was verified by fluorescent in situ hybridization (FISH) as well as copy number variation sequencing (CNV‐seq) based on the next‐ generation sequencing method (>100 Kb). To the best of our knowledge, there have been no reports of XX male with the Yp region transferred to the terminal of chromosome 15 short arm.
A novel UBE2A splice site variant causing intellectual disability type Nascimento
Authors: Yan Shuyuan , Wang Yanling , Chen Ying , Yuan Hongxia , Kuang Xiaoni , Hou Da , Li Xueyi , Pan Linglin , Huang Guangwen , He Jun , Wang Tuanmei , Peng Xiangwen 
Published: July 2022

AbstractX‐linked intellectual disability type Nascimento (XLID) is a rare disease caused by variants in the ubiquitin‐conjugating enzyme E2A gene (UBE2A). Patients with XLID have similar phenotypes, including speech impairments, severe intellectual disability, hearing loss, wide facies, synophrys, generalized hirsutism, and urogenital abnormalities. Till date, only two splice‐site variants of the UBE2A gene have been observed in patients with X‐linked ID type Nascimento. Here, we report the case of a Chinese boy with a syndrome clinically similar to XLID with speech impairment, severe intellectual disability, and moderate hearing loss. However, different characteristics were also present in the patient, including an inability to maintain his head in an upright posture. Both of the patient's palms have a single transverse palmar crease. Subsequent whole‐exome sequencing revealed a novel splice site variant in UBE2A (c.241 + 1 G > A). Our study not only expands the variant spectrum and clinical characteristics of UBE2A deficiency syndrome but also provides clinical evidence for genetic diagnoses.
Synovial hemangioma: A rare cause of chronic knee pain
Authors: Slouma Maroua , Hannech Emna , Msolli Amjed , Dhahri Rim , Kouki Sami , Metoui Leila , Gharsallah Imen , Louzir Bassem 
Published: July 2022

AbstractSynovial hemangioma is a rare benign vascular tumor responsible for chronic knee pain and swelling. Given its non‐specific symptoms, synovial hemangioma is often misdiagnosed. We report a case of synovial hemangioma of bilateral knee joints occurring in a young military man.