bluuebunny/crossref_metadata_2025_split huggingface dataset:
EPO rs1617640 A&gt;C is a protective factor for chronic obstructive pulmonary disease: a case control study
Authors: Wang Yunchao , Li Zhi , Zhang Xiaoyi , Lin Ao , Chen Cuiyi , Zeng Xiaobin , Pan Yujie , Mao Chun , Xie Chenli , Huang Dongsheng , Deng Yibin , Zhang Xuhui , Lu Jiachun , Wang Xinhua 
Published: October 2022

AbstractBackground The occurrence and development of chronic obstructive pulmonary disease (COPD) are regulated by environmental and genetic factors. In the absence of oxygen, Erythropoietin (EPO) satisfies the body's need for oxygen by promoting the production of red blood cells. Hypoxia was proven to be a common physiological condition within COPD progression and associated with many complications. Some studies have found thatEPOis involved in the development of COPD. But the mechanism has not been fully proven. Methods We conducted a case-control study enrolled 1095 COPD patients and 1144 healthy controls in Guangdong Province to evaluate the association betweenEPOpolymorphism (rs1617640 A > C, rs507392 A > G, rs564449 G > T) and COPD susceptibility. And recruited 872 participants from southern Gansu Province to verify the effect ofEPOpolymorphisms on lung function. Results We found thatEPOrs1617640 C allele significantly reduced COPD susceptibility in southern Chinese (AC vs. AA: adjusted OR = 0.805, 95%CI = 0.669–0.969; AC + CC vs. AA: adjusted OR = 0.822, 95%CI = 0.689–0.980). However, there was not any association between rs507392A > G and rs564449G > T polymorphisms and COPD susceptibility (P > 0.05). We further observed that the rs1617640 C allele was significantly associated with higher FEV1and FVC in Guangzhou and Gansu populations (bothP < 0.05). In brief, the level of FEV1and FVC increased with the increase of the C allele number. We modeled relative risk for men and women, in which the population-attributable risks were 0.449 (0.258–0.641) and 0.262 (0.128–0.396) respectively. Smoking status, coal as fuels, education level, and rs1617640 A > C were finally retained for males, while smoking status, biomass as fuels, and1617640 A > C were retained for females. In the end, using the method developed by Gail and Bruzzi, we fitted a 10-year absolute risk model for southern Chinese with different individual relative risks, which was presented as a table. Conclusions In conclusion, this study found thatEPOrs1617640A > C polymorphism is associated with COPD susceptibility in southern Chinese, and the C allele was associated with better lung function. In addition, it could also be considered as a genetic marker associated with environmental factors to predict the absolute 10-year risk of COPD in southern Chinese.
Effect of Educational Intervention Programme on the Health- Related Quality of Life (HRQOL) of Individuals With Type 2 Diabetes Mellitus in South-east, Nigeria.
Authors: Okafor Christiana Nkiru , Akosile Christopher Olusanjo , Nkechi Chiejina Edith , Okonkwo Uchenna Prosper , Nwankwo Chinenye Mercy , Okoronkwo Ijeoma Lewechi , Okpala Pat Uzo Okpala , Afonne Anulika Johnson 
Published: October 2022

Abstract

Background
Diabetes is one of the most important chronic diseases that have a great impact on health as people with diabetes are constantly being reminded of their disease daily; they have to eat carefully, exercise and test their blood glucose. They often feel challenged by their disease because of its day-to-day management demands and these affect their quality of life. The study aimed at determining the effect of an educational intervention program on the quality of life of Individuals with type 2 Diabetes Mellitus in South East, Nigeria.
Methods
A quasi-experimental controlled study involving three hundred and eighty-two (382) type 2 DM persons recruited from the tertiary health institutions in South East, Nigeria, and randomly assigned to intervention and control groups respectively. Data was collected from the diabetic clinics of the health institutions using the SF – 36 questionnaires. Pretest data collection was done, thereafter, education on self-care was given to the intervention group. After a 6months follow-up, post-test data were collected from both groups. Analysis was done using an Independent t-test, Analysis of Covariance (ANCOVA), Paired Samples Test, and Spearman rank order correlation at 0.05 alpha level.
Results
The control group indicated significantly higher mean HRQOL scores in most domains of the HRQOL before intervention (t = -1.927 to -6.072, p < 0.05). However, 6 months after the intervention, the mean HRQOL scores of the intervention group increased significantly in all the domains of HRQOL (p < 0.05). Also, the overall mean HRQOL score of the intervention group increased significantly by 5.87point after intervention (64.72 ± 10.96 vs 58.85 ± 15.23; t = 4.349. p = 0.001). Age was inversely correlated with some domains of HRQOL; as age increases, HRQOL decreases in those domains. Gender had no significant influence on HRQOL.
Conclusion
Educational intervention was very effective in improving HRQOL in individuals with type 2 DM. Hence, it is recommended for inclusion in all diabetes care plans.
The mediating effect of psychological empowerment on the relationship between work environment and clinical decision-making among midwives: A multicentre cross-sectional study
Authors: Zeng Jing , Guo Sheng-Bin , Zheng Qing-Xiang , Liu Xiu-Wu , Lin Hui-Ming , Hu An-Feng , Yang Yan , Wei Bi-Rong 
Published: October 2022

Abstract
Background
Clinical decision-making is considered an essential behaviour in clinical practice. However, no research has been done to examine the associations among midwives’ clinical decision-making, work environment and psychological empowerment. Thus, the study aims to determine the influence of work environment on midwives’ clinical decision-making and confirm the mediating role of psychological empowerment.
Method
602 registered midwives from 25 public hospitals in China were included in this multicentre cross-sectional study. A sociodemographic questionnaire, Work Environment Scale, Psychological Empowerment Scale and Clinical decision-making Scale were applied. A hypothetical path model was examined with SPSS 26.0 and AMOS 26.0.
Results
The mean clinical decision-making score was 143.03 ± 14.22, at an intermediate level. The hypothesis model of this study fitted the data well, and the results showed that work environment and psychological empowerment positively affected clinical decision-making for midwives; psychological empowerment partly mediated the relationship between work environment and clinical decision-making for midwives.
Conclusions
Midwives’ clinical decision-making could be promoted directly or indirectly by providing a healthy work environment and improving psychological empowerment. It is essential for hospital managers to pay attention to the assessment of the midwives’ work environment and actively improve it. Furthermore, managers can also promote midwives’ clinical decision-making behaviour by enhancing their psychological empowerment.
Transportation of Dislocation Plasticity in a Dual-Phase TiMo Alloy
Authors: Men Jinghui , Fu Xiaoqian , Yu Qian 
Published: October 2022

Abstract
The structural design of dual-phase or multiphase advanced alloys depends on understanding the coordinate deformation of various phases under applied stress, in which experimentally disclosing the microscopic picture of dislocation plasticity transportation is critical. In this study, in situ transmission electron microscope tensile tests were used to examine the dislocation behaviors occurring during the deformation of a dual-phase Ti-10(wt.%) Mo alloy having hexagonal close-packed α phase and body-centered cubic β phase. The findings demonstrated that the dislocation plasticity preferred to transmit from alpha to alpha in the longitudinal axes of each plate, regardless of where dislocations were formed. Dislocations for the α phase were initially activated in the α phase and migrated along the plate’s longitudinal axis. Specific sites with local stress concentration were created at the intersection of various alpha plates, which made it easier to transfer dislocation plasticity from one plate to another. Nearby α plates’ majority of newly excited dislocations kept moving in a longitudinal direction. Dislocations pinned on the α-β phase boundary of the β phase would decrease resistance as the stress grew and migrate along the longitudinal direction in the α phase. Dislocation slips occurred in multiple directions as a result of α plates’ variable orientation, which might be advantageous for uniform plastic deformation. The findings provide insight into the use of microstructure engineering to enhance the mechanical properties of materials.
Classification of Amyloidosis SubTypes by Synchrotron InfraRed MicroSpectroscopy
Authors: Wellner Nikolaus , Wolna Magda , Bijzet Johan , Diepstra Arjan , Yancheva Slaveya , Cinque Gianfelice , Neda Sophia , Mazibrada Jasenka 
Published: October 2022

Abstract
The aim of this study was to assess the use of Synchrotron Radiation Fourier Transform InfraRed microspectroscopy (SR micro-FTIR) in the diagnosing and subtyping of different misfolded proteins in various tissues and organs. To this end, specimens from various organ sites were analysed by IR biospectroscopy. Multivariate data analysis methods were applied to correlate the spectral datasets with histological and immunohistochemical findings and clinical data.
The results of the study reveal significant segregation of tissues affected by amyloidosis and controls, but the amount of amyloid β-sheet did not correlate with the disease state. Amyloid light-chain type specimens contained more β-sheet structures than non-Amyloid A types, and Transthyretrin type showed very little. The Insulin type behaved differently altogether. The amyloid type apparently had a bigger effect on the spectra than the tissue origin. However, there were common spectral changes probably related to tissue damage which indicated the transition from healthy to diseased state. This suggests that not only SR micro-FTIR can be used for detection of amyloidosis, but also for distinguishing different subtypes, and can be an efficient and reliable alternative diagnostic tool in detection and subclassification of amyloid deposits.
Prevalence and associated factors of modern contraceptive discontinuation among sexually active married women in Nigeria
Authors: Kupoluyi Joseph Ayodeji , Solanke Bola Lukman , Adetutu Olufemi Mayowa , Abe John Olugbenga 
Published: October 2022

Abstract
Background
Contraceptive discontinuation for reasons other than the desire for pregnancy is associated with a high rate of unintended pregnancies leading to unsafe abortions, maternal morbidity and mortality. In Nigeria, little is known about modern contraceptive discontinuation using the calendar data. Thus, this study examined the prevalence and associated factors of modern contraceptive methods discontinuation among sexually active married women in Nigeria.
Methods
Out of the total sample of 41,821 women (15–49 years) in the individual recode (IR) dataset of the 2018 Nigeria Demographic and Health Surveys (NDHS) with reproductive calendar history, this study analysed a weighted sample size of 3,433 currently sexually active married or in union women who have ever used a modern contraceptive 5 years before the survey and with complete reproductive histories and are not sterilised or declared infecund. The outcome variable was modern contraceptive discontinuation (Pill, IUD, Injections, diaphragm, male condom, female sterilization, male sterilization, implants, female condom, foam/jelly, and lactational amenorrhea) which was disaggregated based on whether discontinuation occurred even though they are still at risk of unwanted pregnancy or not. The explanatory variables examined are the socio-demographic characteristics of the respondents (age, wealth index, religion, education, marital duration, media exposure, and visitation to health facilities in the last 12 months). Data were analysed and displayed using frequency tables and charts, Pearson's chi-square test, and the binary logistic regression model.
Results
Among the sampled women, 35.8% discontinued using modern contraceptives with 45.8% of the women discontinuing using modern contraceptives while at risk of pregnancy. The most modern method discontinued was Injections (25.2%) while the commonest reason for modern method discontinuation was because they wanted to become pregnant (36.1%). Associated factors of modern contraceptive discontinuation among Nigerian women were: marital duration (AOR = 3.47; 95%CI: 2.0–6.0), visitation to a health facility in the last 12 months (AOR = 0.58; 95%CI: 0.4–0.8), education (AOR = 2.00; 95%CI: 1.2–3.4), wealth quintile (AOR = 0.81; 95%CI: 0.4–1.9) and region of residence (AOR = 2.73; 95%CI: 1.6–4.7).
Conclusion
This study concluded that modern contraceptive discontinuation was high. Region of residence, health facility visitation and marital duration were significantly related to modern contraceptive discontinuation. The study suggests that policymakers should recognise women's ability to visit a health facility, marital duration, and region of residence are significantly associated with modern contraceptives. Policymakers must recognise these factors to increase modern contraceptive use in the country.
Copula Approach to Reliability Modelling and Performance Estimation of a Serial Fog-to-Fog Collaboration using Software Defined Network
Authors: Yusuf Ibrahim , Musa Ismail Muhammad , Ismail Abdulkarim Lado 
Published: October 2022

Abstract
Because of its logically centralized design, Software-defined Networking (SDN) is vulnerable to a variety of adversarial attacks. These attacks have the possibility of degrading the coordinated network's efficiency or, in the most severe scenario, bring it down. As a result, SDN efficiency must be assessed and estimated to ascertain its performance through reliability, mean time to failure (MTTF), cost, MTTF sensitivity and availability.In this paper, a system with four subsystems, (subsystem-1, subsystem-2, subsystem-3 and subsystem-4) is studied. All the four subsystems are connected in a series configuration. Subsystem- 1 has only one unit, subsystem-2 has three units connected in parallel working under 1-out-of-3: G; policy, subsystem-3 has two units connected in series, and subsystem-4 has two units connected in parallel working under 1-out-of-2: G; policy. The system is assumed to work in good operating conditions with different failure rates and repair rates. Laplace transforms and Supplementary variable techniques were used to study the system. Availability, reliability, mean time to failure (MTTF), sensitivity, and cost analysis has been evaluated for particular values of the failure and repair rates. Tables and figures were used to demonstrate the evaluated results.
Cost Management for Pricing by Tanaka Technique (Case: An Experience from Automobile Industry)
Authors: Roodposhti Maysam Shafiee , Asrehazer Amirhossein Sabooni , Hedayatizafarghandi Mohammadhadi , Mirghafoori Seyed Habibollah , Azizi Shirin 
Published: October 2022

Abstract
One of the most pressing issues in today's world is minimizing production costs. Similarly, the cost management of the product to be produced occurs during the design stage; that is, the finished price of the product is determined and the design is completed with the goal of reaching this price. Given the importance and position of the automobile industry, the goal of this research is to be able to perform cost management in this industry. The "Tanaka" method was used in this descriptive-analytical model to provide an innovative model for cost management during the design phase of the automobile engine. Tanaka is a technique that exhibits the cost allocation deviation from what it should be based on what is currently happening. The research findings revealed that two pieces are worth more than their value, while the quality of several pieces has not been paid according to their value, and they cost less than their value.
Land Use and Land Cover Change and Its Impact on Flood Hazard Occurrence in Wabi Shebele River Basin of Ethiopia
Authors: Wudineh Fraol Abebe 
Published: October 2022

Abstract
Land-use and land-cover (LULC) changes can impact the hydrological conditions such as land surface coefficient, runoff, infiltration, and hydrographic characteristics of the watersheds. This study investigates the changes in LULC and its impact on water resources of the Wabi Shebele basin using Soil and Water Assessment Tool (SWAT) and a Separation method. Surface and groundwater parameters in northwestern part of the basin; and soil and surface parameters in the eastern highland and southern lowland part of the basin are the most sensitive parameters identified for water production. Out of ten LULC types that exist in the basin, three of them (i.e., cropland, grassland, and bare land) showed growth while two LULC types (i.e., forest and woodland) shows a significant decrease in the past four decades from the 1980s to 2010s. The coverage of cropland was increased by 48.63% while forest and woodland were decreased by 49.14% and 14.76% respectively in the period. Streamflow simulated during this period indicates increases in those watersheds shows significant cropland increases and forest coverage decreases particularly in Wabi at Dodola, Maribo, Robe, and Erer watersheds. Flood indices (i.e., AMAX, SMW, SMSp, and SMSu) calculated from simulated daily streamflow under different LULC map indicates increasing in the middle and northwestern watersheds up to 1.83% and 0.44% respectively. The separation method performed to estimate the impact level of LULC change impact change on flood discharge shows that LULC change has comparable impact level with climate change on streamflow and flood values particularly in middle part of the basin.
Genome-wide identification and characterization of Glutathione S-transferase gene family in Cajanus cajan and their expression profiling under different developmental stages in anatomical tissues
Authors: Vaish Swati , Gupta Divya , Jain Muskan , Verma Mansi , Shukla Rajeev , Prakash Abhishek , Singh Nootan , Ansari Mohd Akram , Kaur Gurjeet , Basantani Mahesh Kumar 
Published: October 2022

Abstract
Plant glutathione S-transferases (GSTs) are multifunctional conserved protein superfamily that is involved in various biological processes such as growth and development, cellular detoxification, stress biology, and various signaling processes. In the current study, a comprehensive genome-wide identification and characterization of the GST gene family were performed in the agriculturally important legume crop Cajanus cajan. A total of 68 GST genes were identified that belong to eight GST classes based on their conserved domains and motifs. Among 68 CcGST genes, 37 CcGST genes were found on seven Cajanus chromosomes and the remaining CcGST genes were found on the scaffold. Segmental and tandem duplication, both were the driving forces of CcGST gene family expansion. The conserved pattern of exon and intron structure among the different GST classes was observed. The secondary prediction showed the dominance of α- helices. Ser is the highly phosphorylated site in CcGSTs. The subcellular localization prediction of CcGSTs revealed their dominance in the cytoplasm. The physicochemical properties of major CcGST proteins reveal that they are acidic in nature. The expression profiling study revealed the high expression of CcGSTU38, CcGSTU40, CcGSTU44, CcGSTL3, CcGSTL4, CcEF1G1, CcEF1G2, CcDHAR2 and CcGSTF6 in most of the developmental stages in different anatomical tissues. The molecular docking study of highly expressed CcGSTU38 with eight herbicide safeners revealed its highest binding affinity with Fenclorim (-5.44 kcal/mol). This gene could be a potential candidate for future molecular characterization under herbicide stress. The results of the current study endow us with the further functional analysis of Cajanus GSTs in the future.
Response of rumen fermentation and microbiota to high-energy diet in fattening sheep
Authors: Ge Ting , Yang Chen , Li Bo , Huang Xiaoyu , Zhao Leiyun , Zhang Xiaoqiang , Tian Lintao , Zhang Enping 
Published: October 2022

Abstract
Background
In mutton sheep production, higher dietary energy is often used to achieve better animal performance. Whereas, changing the diet formula will affect rumen fermentation and microbiota of ruminants. In this study, we investigated the effect of dietary energy on rumen fermentation and ruminal microbiota in fattening sheep. Fifteen 2-month-old white-headed Suffolk sheep (♂) × Hu sheep (♀) crossbred lambs were randomly divided into 3 treatments: 8.67 MJ/kg (LE, n = 5), 10.38MJ/kg (CON, n = 5), and 12.31 MJ/kg (HE, n = 5) based on the dietary energy of feeds fed.
Results
After 70 days of feeding, sheep were slaughtered, and the ruminal fluids were collected and analyzed to determine fermentation parameters, microbiota was determined using metagenomics sequencing. We found that there was no effect on the microbial cell protein (MCP) and butyric acid concentration was significantly high in the HE group. Metagenomic sequencing revealed that ACE and Chao indexes of the HE group were significantly decreased. Among the major classified taxa, 4 genera across all the kingdoms differed in relative abundance among the three dietary energy levels. Correlation analysis revealed that the relative abundances of Prevotella_brevis, Succiniclasticum_ruminis, Prevotellaceae_bacterium, and Lachnospiraceae_bacterium were significantly correlated with rumen fermentation. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis further showed high-energy diet increased lipid metabolism. The expression of the Carbohydrate-Active enzymes (CAZy) gene indicated which participates in energy metabolism increased, but those which regulate plant cell wall degradation decreased in the HE group.
Conclusions
These results suggest that a high-energy diet had limited influence on the rumen fermentation pattern. Whereas, a high-energy diet changes rumen microbiota composition which leading microbial lipid metabolism enhanced and crude fiber's metabolism capacities weakened. Our results provide scientific evidence for fattening sheep production.
An insight into mitochondrial genomes of Trichoderma afroharzianum strains: a comparative and evolutionary analysis
Authors: ÖZKALEKAYA Evrim , DOĞAN Özgül , BUDAK Mahir , KORKMAZ Ertan Mahir 
Published: October 2022

Abstract
Trichoderma afroharzianum (Ascomycota: Hypocreales) is known as an important mycoparasite and biocontrol fungus and feeds on fungal material by parasitizing other fungi. Recent studies indicate that this species is also an ear rot pathogen in Europe. Here, the complete mitochondrial genome (mitogenome) of three T. afroharzianum strains was sequenced using next generation sequencing and comparatively characterised by the reported Trichoderma mitogenomes. T. afroharzianum mitogenomes were varying between 29,511 bp and 29,517 bp in length, with an average A + T content of 72.32%. These relatively compact mitogenomes contain 14 core PCGs, 22 tRNAs, two rRNAs, one gene encoding the ribosomal protein S3 and three or four genes including conserved domains for the homing endonucleases (HEGs; GIY-YIG type and LAGLIDADG type). All PCGs are initiated by ATG codons, except for atp8, and all are terminated with TAA as a stop codon. A significant correlation was observed between nucleotide composition and codon preference. Four introns belonging to the group I intron were predicted, accounting for about 14.54% of size of the mitogenomes. Phylogenetic analyses confirmed the positions of T. afroharzianum strains within the genus of Trichoderma and supported a sister relationship between T. afroharzianum and T. harzianum + T. lixii. The recovered trees also supported the monophyly of Nectriaceae, Bionectriaceae, Hypocreales incertea sedis, Cordycipitaceae and Hypocreaceae. However, Ophiocordycipitaceae and Clavicipitaceae were found to be paraphyletic.