bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of daily price limits on stock liquidity: Evidence from the Chinese stock market
Authors: Li Hao , Li Zhisheng 
Published: July 2022

AbstractThis study uses a group of specially treated stocks to examine the effect of daily price limits in the Chinese stock market. We show that lower price limits significantly reduce liquidity and widen spreads. These results remain consistent when using difference‐in‐differences regressions with propensity score matching and after conducting regression discontinuity analyses. The findings are more prominent for firms experiencing lower‐limit hits, with higher disclosure quality and lower probability of informed trading before the limit changes. These findings suggest that restrictive price limits cause unexpected behaviour of informed traders, enhance information asymmetry, reduce stock liquidity, and hinder price discovery process.
Virtual reality is beneficial in decreasing pain in labouring women: A preliminary study
Authors: Massov Lorna , Robinson Brian , Rodriguez‐Ramirez Edgar , Maude Robyn 
Published: July 2022

BackgroundWomen use a range of non‐pharmacological pain relief methods to reduce labour pain intensity and to help manage labour pain.AimsThe purpose of this intervention study was to determine whether virtual reality would have an effect on labour pain intensity. Virtual reality has been shown to be effective in reducing pain in other acute pain settings.Materials and MethodsThis study was an intervention study in labour in a cross‐over within‐subjects design (Clinical Trials Registry Number: ACTRN12618001776291P). Fourteen participants reported their pain and had their heart rate and blood pressure measured during active labour while using and not using virtual reality.ResultsThere were significantly lower reported pain scores (6.14 compared to 7.61, P < 0.001) and maternal heart rate (79.86 beats per minute compared to 85.57, P = 0.033) and mean arterial pressure (88.78 mmHg compared to 92.61 mmHg, P = 0.022) were lower when using virtual reality compared to when not using virtual reality during active labour.ConclusionThis study makes an important contribution to the field of virtual reality in labour and birth. It is consistent with other recent findings of reduced pain in labour and links decreased pain scales to heart rate and blood pressure, the physiological markers of pain.
Managing, now becoming, refugees: Climate change and extractivism in the Republic of Nauru
Authors: Morris Julia 
Published: July 2022

AbstractThe Republic of Nauru, the world's smallest island state, was almost entirely economically dependent on the phosphate industry in the twentieth century as part of a colonial extractive arrangement. After the wealth Nauru derived was depleted by the 1990s, the by then sovereign state resurged on the back of the refugee industry, agreeing to process and resettle Australia's maritime asylum‐seeker populations. In this article, I explore how forms of refugee extractivism factor into Nauruans’ ontological experiences of climate change. While Nauruans are imbricated in managing refugees—with an extensive program of financialization and institutionalization in place—environmental changes are heightening the prospect of islanders becoming refugees. I argue that Nauruans’ understandings of refugeehood are entangled in the operations of a local industry in refugees but also humanitarian philanthropic portrayals. In Australian activist campaigns, Nauruans are distanced from refugees through representations of savagery and underdevelopment. These discourses intersect with how islanders see and experience refugeehood, while also revealing the fetishizing logics employed by refugee rights campaigners.
Must be Marxist: A Situated History of Danish Radical Geography
Authors: Larsen Henrik Gutzon 
Published: July 2022

AbstractLargely unrecognised in prevailing historical accounts of (radical) geography, Danish university geography from the late 1960s saw the emergence of a strong radical strand. In terms of student support, this radical geography became a dominant feature of geography at the University of Copenhagen, and was a defining element in the establishment of geography at the new Roskilde University Centre. This radical movement spawned its own journal, had a strong impact on upper‐secondary school geography, and played an important part in developing the Nordic critical geography network. As a contribution to the emerging situated histories of radical and critical geography, this article investigates the conditions of possibility for the rise of radical geography in Copenhagen and the movement’s institutionalisation during the 1970s. More briefly, the article also considers the transformative crisis of Danish radical geography in the 1980s.
Editorial: golimumab thresholds to achieve stringent medium‐ and long‐term therapeutic outcomes in patients with ulcerative colitis
Authors: Mantzaris Gerassimos J. , Papamichael Konstantinos 
Published: July 2022

LINKED CONTENTThis article is linked to Taxonera et al papers. To view these articles, visit https://doi.org/10.1111/apt.16964 and https://doi.org/10.1111/apt.17118
Editorial: quality assessment in IBD in high‐resource countries can lead to quality improvement clues for IBD management worldwide
Authors: Bernstein Charles N. 
Published: July 2022

LINKED CONTENTThis article is linked to Hawthorne et al papers. To view these articles, visit https://doi.org/10.1111/apt.17042 and https://doi.org/10.1111/apt.17077
Editorial: effectiveness and safety of vedolizumab in a matched cohort of elderly and non‐elderly patients with inflammatory bowel disease—the IG‐IBD LIVE study. Authors' reply
Authors: Pugliese Daniela , Privitera Giuseppe , Armuzzi Alessandro 
Published: July 2022

LINKED CONTENTThis article is linked to Pugliese et al papers. To view these articles, visit https://doi.org/10.1111/apt.16923 and https://doi.org/10.1111/apt.16957
Editorial: a formula shake each day keeps the complications away – the tolerability and effect of orally‐delivered enteral nutrition in improving post‐operative outcomes in patients with Crohn's disease
Authors: Gold Stephanie L. , Raman Maitreyi 
Published: July 2022

LINKED CONTENTThis article is linked to Meade et al papers. To view these articles, visit https://doi.org/10.1111/apt.17055
Editorial: measuring disease severity in inflammatory bowel disease—the whole is greater than the sum of its parts
Authors: Keefer Laurie , Shapiro Mara J. 
Published: July 2022

LINKED CONTENTThis article is linked to Swaminathan et al papers. To view these articles, visit https://doi.org/10.1111/apt.17058 and https://doi.org/10.1111/apt.17126
Editorial: golimumab thresholds to achieve stringent medium‐ and long‐term therapeutic outcomes in patients with ulcerative colitis—Author’s reply
Authors: Taxonera Carlos 
Published: July 2022

LINKED CONTENTThis article is linked to Taxonera et al papers. To view these articles, visit https://doi.org/10.1111/apt.16964 and https://doi.org/10.1111/apt.17054
Editorial: non‐invasive testing for EoE—does microbiome testing hold the key?
Authors: Naik Rishi D. , Patel Dhyanesh A. 
Published: July 2022

LINKED CONTENTThis article is linked to Facchin et al papers. To view these articles, visit https://doi.org/10.1111/apt.17091 and https://doi.org/10.1111/apt.17144
Editorial: non‐viral hepatocellular carcinoma surveillance—an increasingly severe public health issue. Authors' reply
Authors: Toyoda Hidenori , Kariyama Kazuya , Hiraoka Atsushi 
Published: July 2022

LINKED CONTENTThis article is linked to Toyoda et al papers. To view these articles, visit https://doi.org/10.1111/apt.17088 and https://doi.org/10.1111/apt.17116
Editorial: non‐invasive testing for EoE—does microbiome testing hold the key? Authors' reply
Authors: Facchin Sonia , Calgaro Matteo , Pandolfo Mattia , Caldart Federico , Ghisa Matteo , Vitulo Nicola , Savarino Edoardo Vincenzo 
Published: July 2022

LINKED CONTENTThis article is linked to Facchin et al papers. To view these articles, visit https://doi.org/10.1111/apt.17091 and https://doi.org/10.1111/apt.17130
Beyond structural injustice: Pursuing justice for workers in post‐pandemic global value chains
Authors: Van Buren Harry J. , Schrempf‐Stirling Judith 
Published: July 2022

AbstractThe COVID‐19 pandemic has exacerbated underlying and pre‐existing social, political, and economic conditions that make their negative effects both more likely and more negative, particularly for workers in global value chains (GVCs). In our conceptual and normative paper, we encourage a rethinking of GVCs and associated strategies of lead firms by integrating justice‐related concerns. We argue that the failure to provide just outcomes for GVC workers is due to the existence of persistent structural injustices within GVCs. We seek to address this fundamental question: if the problems of GVCs and employment are due to structural injustices, how can they be addressed and ameliorated? We offer operational principles for firms in this regard, using Iris Marion Young's concept of structural injustice to frame our analysis: (1) adopting shared constraint through inter‐firm cooperation and collective action, (2) minimum, shared standards for GVC worker treatment, (3) worker participation in GVC governance, (4) focusing on creating genuinely shared value rather than on value extraction from GVC workers, and (5) focusing on worker outcomes instead of processes. Our contribution lies in (1) outlining a relational approach to help lead firms to rethink their fundamental assumptions, strategies, and underlying conditions of GVCs and (2) expanding Young's analysis of structural injustice to GVCs more broadly.
Development and validation of a prognostic scoring model to risk stratify childhood acute myeloid leukaemia
Authors: Li Jun , Liu Lipeng , Zhang Ranran , Wan Yang , Gong Xiaowen , Zhang Li , Yang Wenyu , Chen Xiaojuan , Zou Yao , Chen Yumei , Guo Ye , Ruan Min , Zhu Xiaofan 
Published: July 2022

SummaryTo create a personal prognostic model and modify the risk stratification of paediatric acute myeloid leukaemia, we downloaded the clinical data of 597 patients from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database as a training set and included 189 patients from our centre as a validation set. In the training set, age at diagnosis, ‐7/del(7q) or ‐5/del(5q), core binding factor fusion genes, FMS‐like tyrosine kinase 3‐internal tandem duplication (FLT3‐ITD)/nucleophosmin 1 (NPM1) status, Wilms tumour 1 (WT1) mutation, biallelic CCAAT enhancer binding protein alpha (CEBPA) mutation were strongly correlated with overall survival and included to construct the model. The prognostic model demonstrated excellent discriminative ability with the Harrell's concordance index of 0.68, 3‐ and 5‐year area under the receiver operating characteristic curve of 0.71 and 0.72 respectively. The model was validated in the validation set and outperformed existing prognostic systems. Additionally, patients were stratified into three risk groups (low, intermediate and high risk) with significantly distinct prognosis, and the model successfully identified candidates for haematopoietic stem cell transplantation. The newly developed prognostic model showed robust ability and utility in survival prediction and risk stratification, which could be helpful in modifying treatment selection in clinical routine.
Tumour cell characteristics and microenvironment composition correspond to clinical presentation in newly diagnosed nodular lymphocyte‐predominant Hodgkin lymphoma
Authors: Hartmann Sylvia , Soltani Ahmad Sajad , Bankov Katrin , Bein Julia , Hansmann Martin‐Leo , Rosenwald Andreas , Bernd Heinz‐Wolfram , Feller Alfred , Ott German , Möller Peter , Stein Harald , Klapper Wolfram , Borchmann Peter , Engert Andreas , Eichenauer Dennis A. 
Published: July 2022

SummaryDifferent studies have characterized the microenvironment and its prognostic impact in classic Hodgkin lymphoma whereas such analyses are pending for nodular lymphocyte‐predominant Hodgkin lymphoma (NLPHL). We thus investigated characteristics of tumour cells and microenvironment in NLPHL and evaluated possible correlations with the clinical presentation. Lymph node samples from 152 NLPHL patients who had first‐line treatment within the randomized German Hodgkin Study Group HD16–HD18 trials were available and analysed with regard to IgD status and nuclear size of the tumour cells as well as presence of PD1‐positive follicular T helper cells and CD163‐positive macrophages in the microenvironment. While large tumour cell nuclei and high numbers of PD1‐positive follicular T helper cells in the microenvironment were more common in patients presenting with early/intermediate stages than in patients with advanced‐stage disease (p < 0.0001, unpaired t‐test; p = 0.0022, Mann–Whitney test), no differences between risk groups were observed in terms of the IgD status of the tumour cells and the content of CD163‐positive macrophages in the microenvironment. PD1‐positive follicular T helper cells were present in both cases with typical and variant growth patterns and rosetting around the tumour cells was observed in 96% of patients, indicating an important role of PD1‐positive follicular T helper cells in NLPHL.
The first Japanese biobank of patient‐derived pediatric acute lymphoblastic leukemia xenograft models
Authors: Tanaka Kuniaki , Kato Itaru , Dobashi Yuu , Imai Jun‐ichi , Mikami Takashi , Kubota Hirohito , Ueno Hiroo , Ito Mamoru , Ogawa Seishi , Nakahata Tatsutoshi , Takita Junko , Toyoda Hidemi , Ogawa Chitose , Adachi Souichi , Watanabe Shinya , Goto Hiroaki 
Published: July 2022

AbstractA lack of practical resources in Japan has limited preclinical discovery and testing of therapies for pediatric relapsed and refractory acute lymphoblastic leukemia (ALL), which has poor outcomes. Here, we established 57 patient‐derived xenografts (PDXs) in NOD.Cg‐Prkdcscidll2rgtm1Sug/ShiJic (NOG) mice and created a biobank by preserving PDX cells including three extramedullary relapsed ALL PDXs. We demonstrated that our PDX mice and PDX cells mimicked the biological features of relapsed ALL and that PDX models reproduced treatment‐mediated clonal selection. Our PDX biobank is a useful scientific resource for capturing drug sensitivity features of pediatric patients with ALL, providing an essential tool for the development of targeted therapies.
LRFN2 binding to NMDAR inhibits the progress of ESCC via regulating the Wnt/β‐Catenin and NF‐κB signaling pathway
Authors: Zhou Yu , Xu Lijuan , Wang Jiru , Ge Beibei , Wang Qiuzi , Wang Tao , Liu Chang , Wei Bin , Wang Qilong , Gao Yong 
Published: July 2022

AbstractAs a neuronal transmembrane protein, leucine‐rich repeat and fibronectin type‐III domain‐containing protein 2 (LRFN2) can recruit and combine with N‐methyl‐d‐aspartate receptors (NMDARs) to promote nerve growth. Genetic studies suggest that mutations in LRFN2 are associated with various cancers. However, the role and mechanism of LRFN2 in the progression of ESCC have not been elucidated. In this study, we demonstrated that LRFN2 was significantly downregulated in ESCC tissues by qRT‐PCR and immunohistochemistry. Low LRFN2 expression was an adverse prognostic factor in patients with ESCC. Overexpression of LRFN2 effectively suppressed the proliferation, migration, invasion, and epithelial‐to‐mesenchymal transition in vitro and tumor growth in vivo. Bioinformatics analysis indicated that Wnt/β‐catenin signaling regulation was one of the most potential mechanisms and studies confirmed that overexpression of LFRN2 obviously downregulated the expression of β‐catenin, c‐Myc, and cyclin D1 in ESCC cells and tumor tissues. Further studies revealed that LRFN2 plays an anti‐ESCC role by binding with NMDAR‐GRIN2B and this effect can be weakened by NR2B‐selective NMDA antagonist‐NMDA‐IN‐1. Moreover, the bioinformatics analysis showed that the interaction of GRIN2B and GSK3β affects the NF‐κB pathway, which was demonstrated by western blot experiments. Collectively, our results indicate that LRFN2 binding to NMDARs inhibits the progression of ESCC by regulating the Wnt/β‐catenin and NF‐κB pathway, which provides a new therapeutic target for improving the prognosis of patients with ESCC.
Structuring of the effects of oral health literacy on dental caries in 12‐year‐old adolescents
Authors: Neves Érick Tássio Barbosa , da Costa Dutra Laio , de Lima Larissa Chaves Morais , Perazzo Matheus França , Ferreira Fernanda Morais , Paiva Saul Martins , Granville‐Garcia Ana Flávia 
Published: July 2022

AbstractObjectivesTo explore the pathways by which oral health literacy is associated with dental caries in adolescents, assessing direct and indirect effects of family cohesion and socioeconomic status.MethodsA population‐based, representative cross‐sectional study was conducted with 740 12‐year‐old adolescents in Campina Grande, Brazil. Parents/guardians answered a sociodemographic questionnaire. Adolescents answered validated questionnaires addressing family cohesion and oral health literacy. Dental caries was diagnosed using Nyvad criteria. Two dentists underwent training exercises for the diagnosis and administration of the questionnaires (k > 0.80). Descriptive analysis was followed by the use of structural equation modelling to determine direct and indirect associations between the variables incorporated into the theoretical model of the study (95% CI).ResultsOral health literacy (standardized coefficient: −3.472, p < .01) and mother's schooling (standardized coefficient: −0.405, p < .01) were directly associated with dental caries, whereas family cohesion and socioeconomic status exerted an indirect effect on the occurrence of dental caries in the adolescents.ConclusionsSociodemographic factors, family characteristics and oral health literary are associated with dental caries in 12‐year‐old adolescents.
Association between dental caries and molar‐incisor hypomineralisation in first permanent molars: A hierarchical model
Authors: Oreano Marcela D'avila , Santos Pablo Silveira , Borgatto Adriano Ferreti , Bolan Michele , Cardoso Mariane 
Published: July 2022

AbstractObjectiveTo assess whether the prevalence of dental caries is associated with the presence of molar‐incisor hypomineralisation (MIH) in first permanent molars (FPMs).MethodsA cross‐sectional study was conducted with a sample of 5368 FPMs from 1342 children aged 8–10 years from Florianopolis, Brazil. Dental caries was evaluated with the Decayed, Missing and Filled Teeth (DMFT) index and MIH was assessed according to the European Academy of Paediatric Dentistry (EAPD) criteria. The sociodemographic data were obtained with a questionnaire sent to caregivers. A hierarchical repeated measures Poisson regression, considering dependency among observations, was performed, since the unit of analysis was the tooth.ResultsThe presence of MIH was associated with a 6.15 times higher prevalence of dental caries in FPMs (PR: 6.15; 95%CI: 4.18–9.04). A monthly family income ≤2 minimum wages and the caries experience in the primary teeth were also significantly associated with greater prevalence rates of dental caries in FPMs.ConclusionThe presence of MIH showed a significant association with the prevalence of dental caries in FPMs. Thus, dentists should be alert to cases of MIH. Once the condition is detected, preventive measures should be taken to prevent enamel breakdown and the development of dental caries lesions.
Monoclonal antibody drugs for the treatment of multiple sclerosis and neuromyelitis optica spectrum disorder
Authors: Murata Hisashi , Sugiyama Yasuko , Shiraishi Naoyuki , Kihara Keigo , Kinoshita Makoto , Okuno Tatsusada 
Published: July 2022

AbstractIn recent years, remarkable advances have been made in the treatment of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). In particular, several monoclonal antibody drugs have been approved for the treatment of MS and NMOSD, significantly expanding the therapeutic options for treating these diseases. This article provides an overview of the monoclonal antibodies available to treat patients with MS and NMOSD, including drugs that are not yet approved in Japan.
Einflussfaktoren auf oberflächliche und tiefe Beinvenenthrombosen nach Schaumverödung von Krampfadern
Authors: Danneil Olivia , Dörler Martin , Stockfleth Eggert , Stücker Markus 
Published: July 2022

ZusammenfassungHintergrundBei einer Schaumsklerosierungstherapie von Varizen können als Nebenwirkungen sowohl tiefe (TVT) als auch oberflächliche Beinvenenthrombosen (OVT) auftreten. Noch weitgehend unklar sind die Risikofaktoren, welche die Entstehung einer OVT oder TVT nach Schaumsklerosierung begünstigen. Das Ziel dieser retrospektiven Analyse war, anhand eines größeren Kollektivs von Patienten mit thromboembolischen Komplikationen sowohl patienten‐ als auch eingriffsbezogene Risikofaktoren für thromboembolische Komplikationen durch eine Schaumsklerosierung herauszuarbeiten.Patienten und MethodikInsgesamt wurden 170 Patienten untersucht, die eine Schaumsklerosierung erhielten. Vor dem Stichtag 17. März 2020 wurden die letzten 85 Patienten mit thromboembolischen Komplikationen als Studiengruppe A und die letzten 85 Patienten ohne thromboembolische Komplikationen als Kontrollgruppe B nach Sklerosierung mit aufgeschäumtem Sklerosierungsmittel erfasst und verglichen.ErgebnissePatienten mit thromboembolischen Komplikationen hatten häufiger eine Thrombophilie (11/85 vs. 3/85). Die mittleren BMI‐Werte waren in Gruppe A (25,9 ± 5,1) signifikant niedriger als in Gruppe B (28,0 ± 7,2) (P = 0,034). Thromboembolische Komplikationen zeigen sich nach Schaumsklerosierung eher am Unterschenkel (61/105) als am Oberschenkel (1/13) (P < 0,001) dabei häufiger nach dorsaler als nach ventraler Schaumsklerosierung (39 von 47 vs. 5 von 40, P < 0,001). Von den 39 thromboembolischen Komplikationen am dorsalen Unterschenkel waren 23 Muskelvenenthrombosen.SchlussfolgerungDas Risiko für Muskelvenenthrombosen nach Schaumsklerosierung ist vor allem bei schlanken Patienten, welche am dorsalen Unterschenkel sklerosiert werden, erhöht.
Perioperatives Management von Antithrombotika in der Dermatochirurgie – Eine Umfrage unter Dermatologen in Deutschland
Authors: Scherer Fabian David , Nast Alexander , Gaskins Matthew , Werner Ricardo Niklas , Dressler Corinna 
Published: July 2022

ZusammenfassungHintergrund und Zielsetzung: Wir haben in zwei Querschnittsumfragen in den Jahren 2012 und 2017 eine erhebliche Heterogenität im perioperativen Management von Antithrombotika unter Dermatologen in Deutschland festgestellt. Die erste deutsche Leitlinie zu diesem Thema wurde 2014 veröffentlicht und im Jahr 2021 aktualisiert. Wir wollten herausfinden, wie sich der Umgang mit Antithrombotika verändert hat.Methodik: Wir haben eine papierbasierte Umfrage an 1115 Dermatologen in ganz Deutschland versandt und sie zu ihrem perioperativen Management von Antithrombotika bei Operationen an der Haut sowie zu ihrer Vertrautheit mit der Leitlinie befragt.Ergebnisse: Wir erhielten Antworten von 65 stationär tätigen und 202 niedergelassenen Dermatologen. Die meisten Dermatologen gaben an, Antithrombotika bei kleineren Operationen fortzuführen. Ein nennenswerter Anteil der Dermatologen gab an, bei invasiveren Operationen die Behandlung mit Phenprocoumon perioperativ zu pausieren und mit Heparin zu überbrücken. Bei Kombinationstherapien war das Fortführen der Behandlung weniger verbreitet.Schlussfolgerungen: Der Anteil der Dermatologen in Deutschland, die angaben, Antithrombotika bei Operationen an der Haut leitlinienkonform zu managen, ist seit 2012 gestiegen. Das Fortführen von Antithrombotika bei großen Exzisionen und Wächterlymphknotenexstirpationen, der Verzicht auf die Überbrückung von Phenprocoumon mit Heparin und das perioperative Fortführen antithrombotischer Kombinationstherapien müssen jedoch weiterhin propagiert werden, insbesondere unter niedergelassenen Dermatologen.