bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between eating behaviours and cardiometabolic risk among adolescents in the Health Outcomes and Measures of the Environment study
Authors: Zhang Zhuoya , Li Nan , Buckley Jessie P. , Cecil Kim M. , Chen Aimin , Eaton Charles B. , Kalkwarf Heidi J. , Lanphear Bruce P. , Yolton Kimberly , Braun Joseph M. 
Published: September 2022

SummaryBackgroundEating behaviours are associated with childhood obesity, but their associations with cardiometabolic risk are less clear.ObjectivesWe evaluated cross‐sectional associations between eating behaviours and cardiometabolic risk among 185 adolescents (age 12.4 ± 0.7 years; 53% female; body mass index (BMI)‐z 0.72 ± 1.37) from Cincinnati, Ohio (HOME Study; enrolled 2003–2006).MethodsCaregivers assessed adolescents' eating behaviours with the Child Eating Behaviour Questionnaire. We computed adolescents' cardiometabolic risk scores based on HOMA‐IR, triglycerides to high‐density lipoprotein cholesterol ratio, adiponectin to leptin ratio, systolic blood pressure, and cross‐sectional area of fat inside the abdominal cavity. Using multivariable linear regression models, we estimated associations of eating behaviour subscales with cardiometabolic risk scores or individual risk components.ResultsEmotional overeating (ß = 1.34, 95% CI: 0.67, 2.01), food responsiveness (ß = 0.99, 95% CI: 0.41, 1.57), and emotional undereating (ß = 0.64, 95% CI: 0.08, 1.21) were associated with higher cardiometabolic risk scores. Satiety responsiveness (ß = −0.79, 95% CI: −1.59, 0.00) was associated with lower cardiometabolic risk scores. Adjusting for adolescent BMI‐z at age 12 attenuated these associations, suggesting that adiposity may mediate these associations.ConclusionHedonistic eating behaviours were associated with higher cardiometabolic risk in these adolescents.
Sublethal chlorantraniliprole exposure induces autophagy and apoptosis through disrupting calcium homeostasis in the silkworm Bombyx mori
Authors: Ye WenTao , Dai MinLi , Bian DanDan , Zhu QingYu , Li Xin , Sun HaiNa , Li FanChi , Wei Jing , Li Bing 
Published: September 2022

AbstractThe intensive application of chlorantraniliprole (CAP) leaves residues in the environment, posing a potential threat to non‐target organisms. In the present study, we investigated the adverse effects of sublethal CAP exposure on Bombyx mori. Sublethal CAP (0.02 mg/L) was shown to induce the release of intracellular Ca2+ in BmN cells. Meanwhile, Ca2+‐dependent genes were induced in the midgut at 72 h after CAP (0.01 mg/L) exposure, and damaged mitochondria, autophagosomes, nuclear membrane rupture and condensed chromatin were observed. Moreover, the key genes in the oxidative phosphorylation pathway were significantly down‐regulated. The transcript levels of autophagy‐related genes ATG6 and ATG8 were significantly up‐regulated, and the protein levels of LC3‐II and ATG7 were significantly increased by 3.72‐ and 3.33‐fold, respectively. Additionally, the transcript levels of the upstream genes in the apoptosis pathway (calpain and Apaf‐1) were significantly up‐regulated, the protein levels of the downstream gene caspase 3 and its cleaved form were significantly up‐regulated by 1.97‐ and 4.55‐fold, respectively, consistent with the elevated caspase 3 activity at 72 h. Collectively, these findings demonstrate that intracellular Ca2+ release induced by sublethal CAP inhibits oxidative phosphorylation pathway, which causes mitochondrial dysfunction, leading to autophagy and apoptosis in the midgut of B. mori.
Genetic variability shapes the alternative pathway complement activity and predisposition to complement‐related diseases
Authors: Rodríguez de Córdoba Santiago 
Published: September 2022

SummaryThe implementation of next‐generation sequencing technologies has provided a sharp picture of the genetic variability in the components and regulators of the alternative pathway (AP) of the complement system and has revealed the association of many AP variants with different rare and common diseases. An important finding that has emerged from these analyses is that each of these complement‐related diseases associate with genetic variants altering specific aspects of the activation and regulation of the AP. These genotype–phenotype correlations have provided valuable insights into their pathogenic mechanisms with important diagnostic and therapeutic implications. While genetic variants in coding regions and structural variants are reasonably well characterized and occasionally have been instrumental to uncover unknown features of the complement proteins, data about complement expressed quantitative trait loci are still very limited. A crucial task for future studies will be to identify these quantitative variations and to determine their impact in the overall activity of the AP. This is fundamental as it is now clear that the consequences of genetic variants in the AP are additive and that susceptibility or resistance to disease is the result of specific combinations of genetic variants in different complement components and regulators (“complotypes”).
Residual stress versus microstructural effects on the strength and toughness of phase‐separated PbO–B2O3–Al2O3 glasses
Authors: Santos Gisele G. , Peitl Oscar , Koike Akio , Akiba Shusaku , Sawamura Shigeki , Nagano Mikio , Saijo Yoshitaka , Harako Susumu , Yoshida Satoshi , Zanotto Edgar D. 
Published: September 2022

AbstractA few authors have reasonably proposed that liquid–liquid phase‐separated (LLPS) glasses could show improved fracture strength, Sf, and toughness, KIc, as the second phase could provide a barrier to crack propagation via deflection, bowing, trapping, or bridging. Due to the associated tensile or compressive residual stresses, the second phase could also act as a toughening or a weakening mechanism. In this work, we investigated five glasses of the PbO–B2O3–Al2O3 system spanning across the miscibility gap: Four of them undergo LLPS—three are binodal (two B2O3‐rich and one PbO‐rich) and one is spinodal—and one does not show LLPS (composition outside the miscibility gap). Their compositions were designed in such a way that the amorphous particles are under compressive residual stresses in some and under tensile residual stresses in others. The following mechanical properties were determined: the Vickers hardness, ball on three balls (B3B) strength, and toughness, KIc‐SEVNB (single‐edge V‐notch beam [SEVNB]). The microstructures and compositions were analyzed using scanning electron microscopy with energy‐dispersive X‐ray spectrometry. The spinodal glass showed, by far, the best mechanical properties. Its KIc‐SEVNB = 1.6 ± 0.1 MPa m1/2, which embodies an increase of almost 50% over the B2O3‐rich binodal composition, and 90% considering the PbO‐rich binodal composition. Moreover, its fracture strength, Sf = 166 ± 7 MPa, is one of the highest ones ever reported for an LLPS glass. Fracture analyses evidenced that the spinodal composition exhibited the lowest net stress at the fracture point. Moreover, calculations indicate that the internal residual stress level is the lowest in the spinodal glass. The overall results indicate that the microstructural effect of the spinodal glass is the most significant factor for its superior mechanical properties. This work corroborates the idea that LLPS provides a feasible and stimulating solution to improve the mechanical properties of glasses.
When the going gets tough, do the tough go shopping?
Authors: Pan Xiaodan , Mantin Benny , Dresner Martin 
Published: September 2022

AbstractThis study examines the impacts of consumer confidence on stockpiling behavior and, subsequently, retail inventory management. We show how stockpiling behavior evolved during the “Great Recession” of 2008–2009 as consumer confidence waned and demonstrate the impact of this development on inventory management. Drawing on the two‐segment household inventory theory consisting of nonstockpiling and stockpiling segments, we use a panel dataset (2005–2015) to calibrate household inventory holdings. This dataset then serves as input for a retailer‐level case study. Our empirical analysis reveals significant impacts from changing stockpiling behavior. When consumer confidence is low, both stockpiling and nonstockpiling segments respond by reducing weekly consumption rates; however, the stockpiling segment also significantly lengthens the time between shopping trips, and ultimately increases the duration of inventory holdings. These changes to consumption and stockpiling add complexity to inventory planning, requiring retailers to carefully adjust inventory levels to maintain service levels.
Association between hypertensive disorders during pregnancy and elevated blood pressure in offspring: A systematic review and meta‐analysis
Authors: Yu Huan , Li Wei , Mao Zhengxia , Luo Lijuan , He Na , Dong Wenbin , Lei Xiaoping 
Published: September 2022

AbstractHypertensive disorders during pregnancy (HDP) are associated with cardiovascular disease among mothers and offspring. This meta‐analysis was conducted to further explore the associations between maternal HDP and offspring blood pressure (BP). The authors performed a search strategy in PubMed, Embase, Web of Science, and Cochrane library from database inception to January 2022. Twenty‐four studies regarding HDP were included, with pregnancy‐associated hypertension (PAH), preeclampsia (PE), gestational hypertension (GH), and chronic hypertension included in 12, 16, 6, and 3 studies, respectively. Offspring who were exposed to HDP and PAH in utero had higher systolic BP (2.46 mm Hg, 95% CI: 1.88–3.03 mm Hg; 2.70 mm Hg 95% CI: 1.89–3.51 mm Hg) and diastolic BP (1.38 mm Hg 95% CI: 0.94–1.83 mm Hg; 1.39 mm Hg 95% CI: 0.71–2.06 mm Hg) than those birthed to normotensive mothers. The offspring exposure to PE, GH, and chronic hypertension had higher systolic BP by 1.90 mm Hg (95% CI: 1.39–2.40 mm Hg), 2.47 mm Hg (95% CI: 1.59–3.35 mm Hg), and 7.85 mm Hg (95% CI: 4.10–11.61 mm Hg), respectively, and higher diastolic BP by 0.99 mm Hg (95% CI: 0.50–1.49 mm Hg), 1.04 mm Hg (95% CI: 0.60–1.47 mm Hg), and 2.92 mm Hg (95% CI: 0.98–4.86 mm Hg), respectively. An Egger test and funnel plot confirmed no significant publication bias. In conclusion, offspring exposure to all subtypes of HDP in utero led to higher BP than no exposure. It is necessary to investigate the potential mechanisms to clarify the roles of genetic and environmental factors in these associations, which could provide insight on preventing hypertension and related cardiovascular disease.
Constitutionalizing the EU in an Age of Emergencies
Authors: White Jonathan 
Published: September 2022

AbstractOver the last decade especially, European authorities have successively invoked exceptional measures in the name of exceptional circumstances. This improvised mode of emergency response raises problems for EU legitimacy. After a brief analysis of the core patterns, the article examines the scope for reform. It considers the case for pre‐emptively strengthening the EU's emergency powers in the form of an ‘emergency constitution’. It goes on to argue for more radical EU constitutional change, focused not on regulating the exceptional moment but simplifying and democratizing executive power, such that when hard times arrive it is better tied to a critical public. A concluding section discusses what can be achieved by retrospective contestation, as an interim solution in advance of constitutional change.
The interaction of CD300lf and ceramide reduces the development of periodontitis by inhibiting osteoclast differentiation
Authors: Hu Qiannan , Yang Lisa , Shan Zhongyan , Wen Shuqiong , Lu Huanzi , Zou Zhaolei , Guo Junyi , Liu Xiangqi , Xie Wenqiang , Cao Yang , Wang Zhi , Yang Le , Wang Xi 
Published: September 2022

AbstractAimThe regulation of osteoclasts (OCs) by inhibitory immunoreceptors maintains bone homeostasis and is considered an important determinant of the extent of periodontal pathology. The aim of this study was to investigate the role of the inhibitory immunoreceptor CD300lf and its ligand ceramide in osteoclastogenesis in periodontitis.Materials and MethodsThe expression of CD300lf was measured in vitro and in a ligature‐induced periodontitis model. The effect of CD300lf ablation on osteoclastogenesis was examined in ligature‐retained and ligature removal periodontitis models. The effect of ceramide, the ligand of CD300lf, was examined in osteoclastogenesis in vitro and in vivo by smearing 20 μg of ceramide dissolved in carboxymethylcellulose on teeth and gingiva every other day in an experimental periodontitis model and ligature removal model.ResultsCD300lf expression was downregulated during osteoclastogenesis. Ablation of CD300lf in the ligature‐induced periodontitis model increased the number of OCs and exacerbated bone damage. Bone resorption caused by CD300lf ablation was reversible following ligature removal. CD300lf‐ceramide binding suppressed osteoclastogenesis in vitro and inhibited alveolar bone loss in a mouse periodontitis model.ConclusionsOur findings reveal that CD300lf‐ceramide binding plays a critical negative role in alveolar bone loss in periodontitis by inhibiting OCs differentiation.
Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: the Avon Longitudinal Study of Parents and Children
Authors: Lacey Rebecca E. , Gondek Dawid , Smith Brooke J. , Smith Andrew D. A. C. , Dunn Erin C. , Sacker Amanda 
Published: September 2022

BackgroundMaternal depression is a major determinant of offspring mental health. Yet, little is understood about how the duration and timing of maternal depression shapes youth risk for depressive symptoms, which if understood could inform when best to intervene. This study aimed to determine how the timing and duration of maternal depression was related to offspring depression in emerging adulthood, and if these associations varied by sex.MethodsWe analysed data from the Avon Longitudinal Study of Parents and Children (a prenatal cohort in the Avon area of England, 1991–2003), n = 3,301. We applied the structured lifecourse modelling approach to maternal depression (assessed at 13 points from prenatal period to adolescence) and emerging adult depressive symptoms (age 21). Lifecourse models assessed were accumulation (sum of timepoints when maternal depression was reported), sensitive periods (each period assessed as one during which maternal depression has a stronger effect) and instability (frequent fluctuations in maternal depression).ResultsFemale adolescents (n = 2,132) had higher SMFQ scores (mean = 6.15, SD = 5.90) than males (n = 1,169, mean = 4.87, SD = 4.82). Maternal depression was most common in the infancy period (21.2% males; 21.4% females). For males, accumulation was the most appropriate lifecourse model; for each additional period of maternal depression, depressive symptoms in emerging adulthood increased by 0.11 (95% CI: 0.07, 0.15, one‐sided p value ≤ .001). For females, exposure to maternal depression was associated with increasing depressive symptoms in emerging adulthood, with the largest effect in mid‐childhood (increase of 0.27 units, 95% CI 0.03–0.50, p = .015 for difference between mid‐childhood and other time‐periods) and a smaller, equal effect at all other time‐periods (increase of 0.07 units per time‐period, 95% CI: 0.03–0.12, p = .002).ConclusionsThis study highlights the importance of ongoing maternal depression for the development of depression in offspring through to emerging adulthood. Because long‐term exposure to maternal depression was particularly important, early interventions are warranted.
The effects of gamma irradiation and natural aging on the composition of Nongxiangxing baijiu
Authors: He Jiang , Chen Qian , Jia Xin , Wang Yan , Huang Min , Wang GuangXi , Chen Hao , Gao Peng 
Published: September 2022

AbstractThe purpose of this study was to investigate the changes in the composition of Nongxiangxing baijiu (Chinese liquor) over 5 years of natural aging and under different irradiation doses of 60Co. We discuss the differences between the two approaches to aging and provide theoretical support for the feasibility of irradiation aging of baijiu. Low‐dose (3 kGy and 6 kGy) and high‐dose (50 kGy and 100 kGy) irradiation were used to assess the effect of irradiation on baijiu compounds. The results show that the chemical reaction processes of natural aging and irradiation are similar, and both can promote the production of aldehydes and acids in baijiu, which contribute to the flavor of aging. Specifically, after irradiation at ≥3 kGy, furfural was not detected. The content of ethyl linoleate decreased after irradiation at ≤6 kGy, but it was not detected after irradiation at ≥50 kGy. The electronic nose prediction model showed that the flavor of the baijiu after 3 kGy irradiation reached an effect similar to that of natural aging for 1.98 years. The application of 60Co irradiation in the aging of Nongxiangxing baijiu has significant value.Novelty impact statement

The chemical reaction processes of natural aging and irradiation are similar, both can promote the production of aldehydes and acids in baijiu.

The flavor of the baijiu after 3 kGy irradiation reached an effect similar to that of natural aging for 1.98 years.

Furfural and ethyl linoleate can be used as potential indicators to determine whether baijiu was irradiated.
Rice‐based noodle formulation: Consumer preference and optimization by mixture design
Authors: González Luciana C. , Loubes María A. , Bertotto María M. , Tolaba Marcela P. 
Published: September 2022

AbstractThis work focused on rice‐based egg noodles for Western consumers, whose preference for the egg option was corroborated by a survey. A constrained mixture design was used to investigate the effect of functional ingredients (FIs: gum, egg, and modified starch) on noodle quality, adopting egg noodles with 3.2% of guar gum as control. The substitution percentage of rice flour by modified starch was restricted (up to 12.5%) according to dough machinability and noodle extensibility. No differences were found in the Fourier transform infrared spectra of experimental design formulations. The synergistic effects among the FIs evidenced by response surface methodology analysis played a key role in the noodle attributes. Satisfactory values of water absorption (123%) and cooking loss (3.6%) were obtained by combining the minimum amount of gum (50% less than the control) with 10.9% of starch and 13.0% of egg. The extensibility of the optimum noodles was similar to that of the control.Novelty impact statementThe use of a survey turned out to be an easy and practical tool to satisfactorily know the preference of consumers for egg‐noodles. This preliminary survey allowed us to select the proper ingredient, and thereby save time and resources. The incorporation of a novel ingredient such as physically modified rice starch was of great interest. Such ingredient allows for clean labeling and avoids the production of chemical waste. In addition, the gum content could be reduced by half due to the synergy of the starch with the egg and gum.
Effect of yerba mate (Ilex paraguariensis St. Hil.) extract on the drying behavior of cassava starch films enriched with rebaudioside A
Authors: Beuter Daiana A. , Meza Bárbara E. , Brumovsky Luis A. , Peralta Juan Manuel 
Published: September 2022

AbstractIn this study, the drying behavior of cassava starch‐based edible films was investigated. Formulations were elaborated with rebaudioside A, glycerol, and low concentrations (0.5, 2, and 4%, w/w) of yerba mate (Ilex paraguariensis St. Hil.) extract (YM%). Physicochemical properties (pH, apparent viscosity, and density) and film‐forming capacity (dip‐coating method) were evaluated at 25°C. Films were casted by drying and mathematically described using the Henderson and Pabis thin‐layer model. Effective moisture diffusion coefficients (Deff) were determined using theoretical film thicknesses evaluated at the critical moisture content. The Deff dependency on temperature and YM% was analyzed using an Arrhenius‐type model. Based on the results, as YM% increased, values of pH, and apparent viscosity decreased. Low YM% increased the drying rates and the values of Deff of cassava starch‐based edible films elaborated with rebaudioside A as a sweetener and bioactive compound, obtaining the highest values at 4% (w/w) and 70°C.Novelty impact statementThe optimization and control of the drying process are important to produce coated foods with high‐quality and nutritional value in the industry. Yerba mate extract powder added to cassava starch‐based formulations at low concentrations (<5%, w/w) is suitable for obtaining edible films and coatings with higher drying rates and effective moisture diffusion coefficients that control film casting due to the better hydrophobicity and plasticizing effect. This information could be useful to manufacture new film‐forming fluids with bioactive compounds (e.g., rebaudioside A), such as alternative bio‐packages that allow to replace the disposable composite synthetic plastic containers, and products for people with special diet requirements due to its low or sugar‐free nature.
Whole grain cereal flours and honey‐based extruded breakfast cereals: Effect of extrusion processing on functional characteristics, antioxidant properties and hydroxymethylfurfural generation
Authors: Hanuman Bobade , Singh Arashdeep , Sharma Savita , Gupta Antima , Singh Baljit 
Published: September 2022

AbstractThe effect of extrusion processing and honey on the quality characteristics of composite flour‐based directly expanded breakfast cereals was investigated using response surface methodology with feed moisture (FM), extrusion temperature (ET), and honey level as process variables. The FM and ET initially increased and later decreased the expansion of breakfast cereals whereas the bulk density and hardness have followed the opposite trend to that of expansion. The ET had a negative and positive effect on water absorption and water solubility indices, respectively. Honey addition suppressed the expansion and elevated the density and hardness of the breakfast cereals. The optimum processing conditions for producing breakfast cereals consisted of 17.07% FM, 150.39°C ET, and 10.18% honey level. The ET had a negative effect on phenolics and a positive effect on antioxidant activity and hydroxymethylfurfural content whereas honey addition increased the levels of phenolics, antioxidant activity, and hydroxymethylfurfural in breakfast cereals.Novelty impact statementThe use of honey as a sweetener significantly reduced the expansion and increased the density as well as the hardness of the breakfast cereals produced from composite flour of wheat, rice, and corn. However, honey addition limited the loss of phenolics and raised the antioxidant activity of resultant breakfast cereals. The effect of other extrusion variables, particularly extrusion temperature, depended on the honey level in the feed and these variables exhibited interactive and curvilinear effects on the properties of breakfast cereals.