bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scream’s roughness confers a privileged access to the brain during sleep
Authors: Legendre G , Moyne M , Dominguez-Borras J , Kumar S , Sterpenich V , Schwartz S , Arnal LH 
Published: September 2022

ABSTRACTDuring sleep, recognizing threatening signals is crucial to know when to wake up and when to continue vital sleep functions. Screaming is perhaps the most salient and efficient signal for communicating danger at a distance or in conditions of limited visibility. Beyond the intensity or the pitch of the sound, rapid modulations of sound pressure in the so-called roughness range (i.e. 30-150 Hz) are particularly powerful in capturing attention and accelerating reactions. Roughness is an acoustic feature that characterizes alarm signals such as screams. However, whether rough sounds are also processed in a privileged manner during sleep is unknown.We tested this hypothesis by stimulating sleeping human participants with low-intensity screams and neutral calls. We found that screams trigger more reliable and better time-locked responses in wakefulness and NREM sleep. In addition, screams boosted sleep spindles, suggesting elevated stimulus salience. The increase in sleep spindle power was linearly proportional to the roughness of vocalizations, but not to their pitch.These findings demonstrate that, even at low sound intensity, scream’s roughness conveys stimulus relevance and enhances processing in both the waking and sleeping states. Preserved differential neural responses based on stimulus salience may ensure adaptive reactions –and ultimately survival– in a state where the brain is mostly disconnected from external inputs.
NUDT6, the Antisense Protein of FGF2 Gene, Plays a Depressogenic Role by Promoting Inflammation and Suppressing Neurogenesis without Altering FGF2 Signaling
Authors: Uzay Burak , Hökelekli Fatma Özlem , Yılmaz Murat , Esen Emre Cem , Başar Koray , Bahadır-Varol Aslıhan , Ayhan Yavuz , Dalkara Turgay , Eren-Koçak Emine 
Published: September 2022

AbstractFibroblast growth factor-2 (FGF2) is involved in the regulation of affective behavior and shows antidepressant effects through Akt and ERK1/2 pathways. NUDT6 is a protein encoded from FGF2 gene’s antisense strand and its role in the regulation of affective behavior is unclear. Here, we show that increasing NUDT6 expression in the hippocampus results in depression-like behavior in rats without changing FGF2 levels or activating its downstream effectors, Akt and ERK1/2. Instead, NUDT6 acts by inducing inflammatory signaling, specifically by increasing S100A9 levels, activating NF-κB and rising microglia number along with a reduction in neurogenesis. Conversely, inhibition of hippocampal NUDT6 expression by shRNA results in antidepressant effects and increases neurogenesis without altering FGF2 levels. Together these findings suggest that NUDT6 may play a role in major depression by inducing a proinflammatory state and serve as a novel therapeutic target for antidepressant development. This is the first report of an antisense protein acting through a different mechanism of action than regulation of its sense protein. The opposite effects of NUDT6 and FGF2 on depression-like behavior may serve as a mechanism to fine-tune affective behavior. Our findings open up new venues for studying the differential regulation and functional interactions of sense and antisense proteins in neural function and behavior as well as in neuropsychiatric disorders.
Estrogen signaling in the dorsal raphe regulates binge-like drinking in mice
Authors: Torres Irizarry Valeria C. , Feng Bing , Yang Xiaohua , Nirali Patel , Schaul Sarah , Ibrahimi Lucas , Ye Hui , Luo Pei , Carrillo-Sáenz Leslie , Lai Penghua , Kota Maya , Dixit Devin , Wang Chunmei , Lasek Amy W. , He Yanlin , Xu Pingwen 
Published: September 2022

SummaryThe ovarian hormone estrogens promote binge alcohol drinking and contribute to sex differences in alcohol use disorder. However, the mechanisms for estrogen-induced binge drinking are largely unknown. This study aims to test if estrogens act on 5-hydroxytryptamine neurons in the dorsal raphe nucleus (5-HTDRN) to promote binge drinking. We used the drinking in the dark (DID) behavioral test in mice to mimic binge drinking in humans. We found that female mice drank more alcohol than male mice in chronic DID tests. This sex difference was associated with distinct alterations in mRNA expression of estrogen receptor α (ERα) and 5-HT-related genes in the DRN, suggesting a potential role of estrogen/ERs/5-HT signaling in binge alcohol drinking. In supporting this view, 5-HTDRN neurons from naïve male mice had lower baseline neuronal firing activity but higher sensitivity to alcohol-induced excitation compared to 5-HTDRN neurons from naïve female mice. Notably, this higher sensitivity was blunted by 17β-estradiol treatment in males, indicating an estrogen-dependent mechanism. We further showed that both ERα and ERβ are expressed in 5-HTDRN neurons, whereas ERα agonist propyl pyrazole triol (PPT) depolarizes 5-HTDRN neurons and ERβ agonist diarylpropionitrile (DPN) hyperpolarizes 5-HTDRN neurons. Notably, both PPT and DPN treatments blocked the stimulatory effects of alcohol on 5-HTDRN neurons in males, despite the fact that they have antagonistic effects on the activity dynamics of 5-HTDRN neurons. These results suggest that ERs’ inhibitory effects on ethanol-induced burst firing of 5-HTDRN neurons may contribute to higher levels of binge drinking in females. Consistently, chemogenetic activation of ERα- or ERβ-expressing neurons in the DRN reduced binge alcohol drinking. These results support a model in which estrogens act on ERα/β to prevent alcohol-induced activation of 5-HTDRN neurons, which in return leads to higher binge alcohol drinking.
Preliminary prospective study on the predictive significance of plasma miR-30b-5p through the study of echocardiographic modifications in Cavalier King Charles Spaniels affected by different stages of myxomatous mitral valve disease: the PRIME study
Authors: Ghilardi Sara , Lecchi Cristina , Bagardi Mara , Romito Giovanni , Colombo Fabio M. , Polli Michele , Franco Celeste , Brambilla Paola G. 
Published: September 2022

AbstractSpecific microRNAs expressions may accurately characterize different stages of canine myxomatous mitral valve disease. This preliminary study aimed to (1) describe the clinical and echocardiographic parameters of Cavalier King Charles Spaniels affected by myxomatous mitral valve disease at different American College of Veterinary Internal Medicine (ACVIM) stages (B1, B2 and C) and healthy control group (ACVIM A), comparing the parameters collected during the first examination (T0) and the end of the follow-up (T1); (2) assess the association between the values of echocardiographic parameters at T1 and the expression profile of miR-30b-5p at T0. Thirty-five Cavalier King Charles Spaniels (median age 4.29 years and median weight 9 Kg) in different ACVIM stages were included (7 A, 19 B1, 6 B2 and 3 C). Inverse probability weighting analysis was performed to estimate the association of the exposure variable (miR-30b-5p) with the outcome variables (clinical and echocardiographic variables). Time was included as variable.The results pointed out that high levels of plasma miR-30b-5p corresponded to lower values of left ventricular end-diastolic diameter normalized for body weight, end-diastolic and end-systolic volumes indexed for body weight, and left atrium-to aortic root ratio. Hence, higher miR-30b-5p expressions were associated with milder forms of mitral valve disease in our study population. In contrast, the results obtained for the intensity of heart murmur, the mitral regurgitation severity, and the Mitral INsufficiency Echocardiographic score) were not statistically significant. A relationship between high abundance of miR-30b-5p and myxomatous mitral valve disease that appear echocardiographically more stable over time has been demonstrated. In conclusion, Cavalier King Charles Spaniels affected by myxomatous mitral valve disease that at the first cardiologic evaluation showed an upregulation of miR-30b-5p are expected to experience lesser variations on their echocardiographic examination between T0 and T1.
The PROSCOOP10 gene encodes two extracellular hydroxylated peptides and impacts flowering time in Arabidopsis
Authors: Guillou Marie-Charlotte , Balliau Thierry , Vergne Emilie , Canut Hervé , Chourré Josiane , Herrera-León Claudia , Ramos-Martín Francisco , Ahmadi-Afzadi Masoud , D’Amelio Nicola , Ruelland Eric , Zivy Michel , Renou Jean-Pierre , Jamet Elisabeth , Aubourg Sébastien 
Published: September 2022

AbstractThe Arabidopsis PROSCOOP genes belong to a family predicted to encode secreted propeptides which undergo maturation steps to produce peptides named SCOOP. Some of them are involved in defence signalling through their perception by a receptor complex including MIK2, BAK1 and BKK1. Here, we focused on the PROSCOOP10 gene which is highly and constitutively expressed in the aerial organs. The MS/MS analyses of leaf apoplastic fluids allowed the identification of two distinct peptides, named SCOOP10#1 and SCOOP10#2, covering two different regions of PROSCOOP10. They both possess the canonical S-X-S family motif and have hydroxylated prolines. This identification in apoplastic fluids confirms for the first time the biological reality of SCOOP peptides. NMR and molecular dynamics studies showed that the SCOOP10 peptides, although largely unstructured in solution, tend to assume a hairpin-like fold exposing the two serine residues previously identified as essential for the peptide activity. Furthermore, PROSCOOP10 mutations led to an early flowering phenotype and an increased expression of the floral integrators SOC1 and LEAFY, consistent with the transcription of PROSCOOP10 in several mutants displaying an early or late flowering phenotype. These results suggest a role of PROSCOOP10 in flowering time, illustrating the functional complexity of the PROSCOOP family.HighlightThe PROSCOOP10 gene encodes two post-translationally modified extracellular SCOOP10 peptides and acts upstream of SOC1 and LFY to delay flowering.
Attenuation hotspots in neurotropic human astroviruses
Authors: Ali Hashim , Lulla Aleksei , Nicholson Alex S. , Wignall-Fleming Elizabeth B. , O’Connor Rhian L. , Vu Diem-Lan , Graham Stephen C. , Deane Janet E. , Guix Susana , Lulla Valeria 
Published: September 2022

AbstractDuring the last decade, the detection of neurotropic astroviruses has increased dramatically. The MLB genogroup of astroviruses represents a genetically distinct group of zoonotic astroviruses associated with gastroenteritis and severe neurological complications in young children, the immunocompromised and the elderly. Using different virus evolution approaches, we identified dispensable regions in the 3′ end of the capsid-coding region responsible for attenuation of MLB astroviruses in susceptible cell lines. To create recombinant viruses with identified deletions, MLB reverse genetics and replicon systems were developed. Recombinant truncated MLB viruses had wild type-like or enhanced growth and replication properties in permissive cells but were strongly attenuated in iPSC-derived neuronal cultures confirming the location of neurotropism determinants. This approach can be used for the development of vaccine candidates using attenuated astroviruses that infect humans, livestock animals and poultry.
Recent trends in agile new product development: a systematic review and agenda for future research
Authors: Palsodkar Manoj , Yadav Gunjan , Nagare Madhukar R. 
Published: September 2022

PurposeThe market's intense competition, the unpredictability of customer demands and technological advancements are compelling organizations to adopt new approaches, such as agile new product development (ANPD), which enables the introduction of new products to the market in a short span. The existing ANPD literature review articles are lacking in portraying recent developments, potential fields of adoption and the significance of ANPD in organizational development. The primary goal of this article is to investigate emerging aspects, current trends and conduct a meta-analysis using a systematic review of 177 ANPD articles published in peer-reviewed journals between 1998 and 2020.Design/methodology/approachThe articles were categorized based on their year of publication, publishers, journals, authors, countries, universities, most cited articles, etc. The authors attempted to identify top journals, authors, most cited articles, enablers, barriers, performance metrics, etc. in the ANPD domain through the presented study.FindingsThe major themes of research articles, gaps and future trends are identified to assist academicians and ANPD practitioners. This study will benefit ANPD professionals by providing them with information on available literature and current ANPD trends.Originality/valueThrough meta-analysis, this study is one of the unique attempt to categorize ANPD articles to identify research gaps and highlight future research trends. A distinguishing feature of the presented study is the identification of active journals, publishers and authors, as well as enablers, barriers and performance metrics.
Services personalization in digital academic libraries: a Delphi study
Authors: Khavidaki Samaneh , Rezaei Sharifabadi Saeed , Ghaebi Amir 
Published: September 2022

Purpose
This paper aims to explore the realm of literature about personalization of digital library services. This paper focuses on users’ unique needs and will identify different types of personalized services. Therefore, this study has identified different types of services personalization in the context of digital academic libraries.

Design/methodology/approach
In this research, the systematic review method has been used to obtain the relevant indicators of different types of personalization in the context of libraries. To explain basic indicators, a Delphi method has been used. The Delphi panel’s members consisted of 15 experts (faculty members, researchers, professional users and software designers). A purposeful sampling and the Delphi fulfillment process were performed in three rounds. After collecting data, descriptive statistics (mean and standard deviation), inferential statistics (binomial distribution test) and the Kendall coordination coefficient were used to determine the consensus rate among experts.

Findings
A total of 103 indicators were extracted for different types of personalization through a systematic literature review. Of these, 90 indicators were considered significant in the experts’ view. Generally, content personalization, interactive personalization, collaborative personalization and information retrieval personalization are the main components of personalization types, each of which has its own indicators.

Originality/value
This study has dealt with the issue of what is personalized in the context of digital academic library. The findings should be helpful and effective in the development of a holistic view on personalization of services in digital libraries.
Measuring the social sustainability of hotels: a case study from the Canary Islands
Authors: Guzmán-Pérez Beatriz , Mendoza-Jiménez Javier , Pérez-Monteverde María Victoria 
Published: September 2022

Purpose
This study aims to demonstrate the derivation of social sustainability metrics that guide the decision-making of hotel managers regarding sustainability strategies based on the case study of Hotel Tigaiga in the Canary Islands, using a noninstrumental approach of the stakeholder theory.

Design/methodology/approach
The analytic–synthetic method of integrated social value (ISV) was used. Data were collected through semi-structured interviews with the stakeholders’ representatives, direct observations and relevant documents.

Findings
Metrics referring to hotel outputs valued by stakeholders and expressed in monetary terms were obtained.

Research limitations/implications
The findings cannot be directly applied to a similar hotel. Applying the ISV model to a set of similar hotels to standardize outputs and proxies is necessary.

Practical implications
The results can guide efforts to increase the effectiveness and efficiency of Hotel Tigaiga’s social sustainability strategies.

Originality/value
Research on measuring the sustainability of hotels in terms of generating maximum value for society is limited. This study is unique because it demonstrates the process of deriving comprehensible indicators to guide hotel managers toward social sustainability.
Changes in qualities and abilities of Japanese teachers through participation in Global Lesson Study on mathematics
Authors: Sakai Takeshi , Akai Hideyuki , Ishizaka Hiroki , Tamura Kazuyuki , Lee Yew-Jin , Choy Ban Heng , Ozawa Hiroaki 
Published: September 2022

PurposeThe authors aim to determine the effects of Global Lesson Study (GLS) – a two-year, one-cycle program defined as “international cooperative lesson study through international exchange among teachers using ICT” – on intercultural competence for lesson study based on pre- and post-survey conducted for Japanese teachers.Design/methodology/approachIn accordance with the GLS program, mathematics lesson studies on mathematics between Japanese and Singaporean elementary school teachers were conducted over a two-year period. Questionnaire surveys on intercultural competence for lesson study was conducted using 7-point Likert scale and descriptive questions with Japanese teachers (N = 5). Analysis of Wilcoxon's signed rank test and correlation analysis were conducted.FindingsFollowings are identified as the effects of GLS for Japanese teachers: (1) Japanese participants felt improvement of their competence in areas of attitude, internal outcomes and outward impact. (2) Participating in a GLS led to the improvement of Japanese teachers' qualities and abilities for subject teaching related to mathematics education. (3) Improvement of intercultural competence for lesson study was related to each other, and GLS led to improvement of these competences. (4) It was meaningful to have a two-year period to assimilate and adjust to independent experience of the host and guest.Originality/valueThe GLS led to teacher empowerment among this sample, not only as cooperative research, but also at the individual level of teachers where participants continued to develop lessons based on the GLS learning after study completion. This has important implications for the implementation and dissemination of the GLS.
Circular economy performance measurements and blockchain technology: an examination of relationships
Authors: Kouhizadeh Mahtab , Zhu Qingyun , Sarkis Joseph 
Published: September 2022

PurposeThis study proposes a systematic and comprehensive circular economy (CE) performance measure as an instrument to operationalize and quantify circularity. It seeks to evaluate the relative contribution of blockchain technology to evaluate various measures in this study. A general research agenda for investigating blockchain capabilities to performance assessment in CE is presented.Design/methodology/approachEmpirical survey data from 32 CE and blockchain experts are collected to inform this study. Inductive reasoning, heatmaps, and a middle-range theory building approach are utilized to generalize theoretical patterns for blockchain support of CE performance assessment and measurement. A series of propositions are then developed as a middle-range theory for the true, false, perceptible, and hidden affordances of blockchain technology capabilities for CE performance measurement.FindingsOverall, sixteen performance measures and metrics are identified and examined. The authors find most of these measures and metrics – based on literature and expert opinion – can be supported using blockchain technology capabilities. Four major blockchain capabilities, transparency and traceability, reliability and security, smart contracts, and incentivization and tokenization are shown to have varying potential support for CE performance assessment. There needs to be an evaluation of true, false, perceptible, and hidden affordances of blockchain technology capabilities for CE performance measurement in future studies.Originality/valueBlockchain application for CE, and specifically performance measurements, is a new area. Research and practice evaluation on this issue is important but needs substantially additional investigation to help CE progress. This study provides a framework for evaluation and a foundation for future research at the nexus of CE, blockchain technology, and performance measurement.
Analysis of damage evolution and causative factors of outer raceway micromorphology of small needle roller bearings under impact load
Authors: Liu Baoxuan , Feng Yu , Wu Shaolei , Wei Chunjie , Wang Wei 
Published: September 2022

Purpose
This paper aims to investigate the damage evolution of bearing raceways under impact conditions from the perspective of three-dimensional (3D) surface morphology changes and to analyze the causal factors with the aid of simulation.

Design/methodology/approach
An experimental device containing an impact generating mechanism, a transmission mechanism and a torque load is designed for the experiments of impact damage to the outer raceway of a small needle roller bearing HK1208 without an inner ring. Microscopic images and height color maps of each experimental stage were obtained using a 3D laser measurement microscope. The characterization parameters of the surface 3D morphology were extracted and analyzed. Dynamics simulations of the impact condition were performed using the finite element method to investigate the variations and distribution characteristics of the roller forces on the raceway.

Findings
The changes in roughness and 3D micromorphology show that the surface flattening phenomenon caused by the flattening effect occurs before the surface of the bearing raceway is damaged. The result of dynamic simulations shows that the maximum load of the bearing under the impact state is obviously greater than that under a steady state, and the load distribution under the two conditions is significantly different.

Originality/value
This paper provides new ideas for analyzing the damage of bearings under impact conditions by analyzing the real 3D morphology of bearing raceways in combination with the finite element method.
Designing augmented reality services for enhanced customer experiences in retail
Authors: Vaidyanathan Nageswaran , Henningsson Stefan 
Published: September 2022

PurposeTo deliver superior customer experiences, retailers are increasingly turning to augmented reality (AR) technologies for new digital services that can enhance their customer interactions. The potential of AR has been validated in lab experiments, but when implemented in real-world contexts, its commercial impact has been limited. Therefore, this paper investigates how to design AR-based services (AR services) that enhance customer experiences in retail.Design/methodology/approachThe paper uses a conceptual research approach to integrate research on AR in the context of retail, combining customer, retailer, and technical perspectives with the design thinking method to demonstrate how the challenge of AR service design can be addressed through design thinking.FindingsThe paper develops propositions that explain how a design thinking method is useful in the design of effective AR services. The paper also articulates principles for how to implement the design thinking method in the specific context of AR for enhanced customer experiences.Practical implicationsThe study documents critical practices for retailers seeking to be competitive with superior customer experiences under the increasing digitalization of retailer-customer interactions.Originality/valueThe study contributes to the service design literature by answering the call to develop moderately abstracted explanations of how different digital technologies can be used to provision new services in different application domains, with the focus here being the design of AR services in the context of retail.