bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of cooperative spectrum sensing with filtered bank multi carrier utilized for detecting in cognitive radio network
Authors: Perarasi T. , Nagarajan G. , Gayathri R. , Leeban Moses M. 
Published: March 2022

AbstractCognitive radio (CR) is defined as a procedure that uses the range with and without impedance. Elements of psychological radio systems incorporate spectrum sensing, spectrum sharing, spectrum mobility and spectrum decision. This manuscript proposes cooperative spectrum sensing (CSS) with filtered bank multi carrier (FBMC) in cognitive radio network (CRN) for mitigating the interference with proficient bandwidth utilization. Here, five primary users (PU) and one secondary user (SU) are considered. The secondary user occupies the slot only in the absence of primary user. During cooperative spectrum sensing with FBMC evaluation, it produces problem in hidden terminal, false alert and auxiliary client identification with effective radio spectrum sharing for the secondary users, which automatically reduces the channel capacity, energy efficiency, and channel interference. To overcome the issues, optimal red deer algorithm (ORDA) is used in FBMC Weight parameters. The proposed method is executed in MATLAB platform. The simulation outcomes demonstrate that the performance of the proposed CSS‐FBMC‐ORDA has high efficiency with less error rate. The proposed CSS‐FBMC‐ORDA attains higher efficiency of 3.99%, 8.90%, and 4.09%, higher reliability of 5.66%, 9.44%, and 2.43%, lower bit error rate (BER) of 4.756%, 4.86%, and 8.97% when compared with the existing methods, such as spectrum resource optimization for non‐orthogonal multiple access (NOMA) based cognitive radio at 5G communications joint optimization algorithm (JOA) (CSS‐CRN‐NOMA‐JOA), maximizing the total throughput for generalized frequency division multiplexing (GFDM) system using hybrid particle swarm optimization (PSO)‐pattern search (PSO‐PS) approach (CSS‐CRN‐GFDM‐Hyb PSO‐PS), energy efficiency for various spectrum sensing scenarios using a novel hybridization of particle swarm optimization (PSO) with gravitational search algorithm (GSA) (CSS‐CRN‐OFDM‐Hybrid PSO‐GSA) respectively.
Purification, structural characterization, and bioactivities of a polysaccharide from Coreopsis tinctoria
Authors: Yu Qian , Chen Wei , Zhong Jing , Huang Dong , Shi Wenting , Chen Haiyun , Yan Chunyan 
Published: March 2022

AbstractCoreopsis tinctoria Nutt. has been widely cultivated in Xinjiang, Yunnan as well as other western regions of China. In folk medicine, the flower tea C. tinctoria is often used as an adjunctive therapy for diabetes and Alzheimer's disease. To explore the chemicals responsible for the health benefits of C. tinctoria, a water‐soluble polysaccharide (CT70‐1) was isolated from C. tinctoria. The structure feature analyses revealed that CT70‐1 was a heteropolysaccharide with a relative molecular weight of 2.1×103 Da. It consisted of α‐D‐Glcp‐(1→, →4)‐α‐D‐Glcp‐(1→, →5)‐α‐L‐Araf‐(1→, →6)‐2‐OAc‐β‐D‐Galp‐(1→, →3)‐α‐L‐Rhap‐(1→, →3,6)‐β‐D‐Manp‐(1→, →6)‐β‐D‐Manp‐(1→, →1,6)‐β‐D‐Fruf‐(2→, α‐L‐Araf‐(1→, and →3)‐β‐D‐Manp‐(1→. Further, CT70‐1 exhibited α‐amylase and α‐glucosidase inhibitory activity with IC50 values of 2.79 ± 0.17 mM and 3.00 ± 0.02 mM, respectively. Moreover, CT70‐1 significantly inhibited lipopolysaccharide‐stimulated nitric oxide production of RAW264.7 and BV2 cells with IC50 values of 0.07 mM and 0.12, respectively. In conclusion, the above findings provide a foundation for promising natural ingredient CT70‐1 in the food and pharmaceutical industries.
Acute megakaryoblastic leukemia with trisomy 3 and CBFA2T3::GLIS2: A case report
Authors: Gillam Joseph , Catic Aida , Paulraj Prabakaran , Dalton Justin , Lai Guanhua , Jackson‐Cook Colleen , Turner Scott , Ferreira‐Gonzalez Andrea , Barrie Elizabeth 
Published: March 2022

AbstractNon‐Down‐syndrome‐related acute megakaryoblastic leukemia (non‐DS‐AMKL) is a rare form of leukemia that can present with a variety of initial symptoms, including fever, rash, bruising, bleeding, or other more clinically challenging symptoms. Herein, we describe a 19‐month‐old female patient who presented with left lower extremity pain and language regression who was diagnosed with AMKL, not otherwise specified (NOS), on the basis of peripheral blood and bone marrow analysis, as well as cytogenetic and molecular diagnostic phenotyping. Of note, in addition to this patient's karyotype showing trisomy 3, a fusion between CBFA2T3 (core‐binding factor, alpha subunit 2, translocated to, 3) on chromosome 16 and GLIS2 (GLIS family zinc finger protein 2), also on chromosome 16, was observed. Patients with AMKL who have trisomy 3 with CBFA2T3::GLIS2 fusions are rare, and it is not known if the co‐occurrence of these abnormalities is coincidental or biologically related. This highlights the continued need for further expansion of genetic testing in individuals with rare disease to establish the groundwork for identifying additional commonalities that could potentially be used to identify therapeutic targets or improve prognostication.
Long‐term hydro‐meteorology and water quality data from low‐gradient catchments of varying scales on the Santee experimental Forest, South Carolina
Authors: Amatya Devendra M. , Trettin Carl C. , Harrison Charles A. , Arnold Julie A. 
Published: March 2022

AbstractThe forest landscape of the Southeastern Atlantic coastal plain of the United States is experiencing increased threats from extreme precipitation events, tropical storms, flooding, droughts, and growing urbanization impacting on vegetation, road infrastructure, water extraction and other related ecosystem processes (e.g., storm runoff, nutrient and carbon cycling) and functions (e.g., flood protection, aquatic habitat). We describe ongoing hydro‐meteorologic monitoring on two first—(1.6 km2 each), the second—(5 km2), and the third—(52.5 km2) order catchments. The catchments are located on the Santee Experimental Forest at the headwaters of the Cooper River that drains into Charleston Harbour, South Carolina. Monitoring started in 1946, with a gap between 1982 and 1989, includes precipitation, weather, streamflow, water table, and water quality (anions, cations, and physical parameters) at varying temporal scales. The catchments are forest ecosystems dominated by loblolly (Pinus taeda) and longleaf pine (Pinus palustris) (LLP) mixed hardwood stands on the uplands and bottomland hardwoods on well‐drained to poorly‐drained soils characteristic of the low‐gradient Atlantic Coastal Plain. These data support multiple field and modelling studies, ranging from water and carbon budgets to hydrologic and biogeochemical processes to effects of microtopography and extreme climate on hydrology and water quality of these coastal catchments withstands regenerated since Hurricane Hugo (1989). One significant finding from the long‐term data was a reversal of the pre‐Hugo flow pattern between the paired watersheds 3 years after Hugo. This reversal persisted for 10 years and was attributed to change in forest vegetation due to hurricane damage to older pine and larger hardwood stands followed by delayed regeneration before full forest recovery. These publicly available data serve as a reference within a rapidly developing landscape and also for addressing potential impacts of extreme climate and forest disturbance on ecohydrology, biogeochemistry, habitat, water supply and infrastructure using validated models and tools.
What drives the distress risk–return puzzle? A perspective on limits of arbitrage
Authors: Sha Yezhou , Bu Ziwen , Wang Zilong 
Published: March 2022

AbstractEmpirical research has documented a negative relationship between distress risk and stock returns. This negative risk–return trade‐off, known as the distress puzzle, poses a challenge to asset pricing models. In this study, we provide a new explanation of the distress puzzle by considering the effect of arbitrage asymmetry. We find that the negative distress risk–return relation is stronger in stocks that have higher limits of arbitrage. The investors are virtually unable to short sell mispriced high distress risk stocks due to the low supply of lendable stocks from institutions and that arbitrage is costly. In addition, we show that the limits of arbitrage effect is distinct from liquidity effect in explaining the distress puzzle.
β‐Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts
Authors: Guo Qin , Li Yujia , Chen Yuan , Ji Jin , Zheng Shizhong , Xu Xuefen , Zhang Biyun , Ye Jianzhou 
Published: March 2022

AbstractHypertrophic scar (HS) is a condition characterized by excessive synthesis and deposition of collagen. There are many clinical methods to alleviate HS, but most of them are accompanied by many complications. To investigate the effects of β‐Elemene, extracted from the ginger family plant Wenyujin, on human hypertrophic scar fibroblast (hHSFs). Cultured hHSFs and human normal fibroblasts, observed the effect of β‐Elemene on apoptosis, extracellular matrix, and endoplasmic reticulum stress (ERS) by western blot, Real Time‐Polymerase Chain Reaction (RT‐PCR), and flow cytometry. Based on our findings, it is clear that β‐Elemene could inhibit the expression of α‐smooth muscle actin (α‐SMA), collagen I, and fibronectin, reduced collagen deposition. Further studies had found that β‐Elemene could increase the expression of ERS‐related proteins CHOP and Calnexin in a dose‐dependent manner, thereby promoting the aggregation of cleaved‐caspase‐3 and inducing hHSFs to undergo poptosis. This process may depend on the regulation of P53. The results of our study indicates that β‐Elemene induced hHSFs to undergo apoptosis though ERS pathway in a P53‐dependent manner, which means that our research provided a new strategy for the development of drugs for the treatment of HS.
Band selection for mapping chromophores of skin tissue
Authors: Sun Jiuai , Wu Zhonghang , Wang Le , Wu Peiyu , Li Min , Yao Qi , Yao Guangyu 
Published: March 2022

AbstractA numerical approach has been proposed to identify bands for optimally estimating the concentration of three types of viable chromophores within biological tissue. The bands are determined according to the condition number of absorption matrix associated with the attenuation coefficients of chromophores. The effectiveness of different sets of selected band combination was verified by using the spectral reflectance images of skin tissue acquired from standard forearm vascular occlusion tests via a spectroradiometer. Experimental results demonstrated that the concentration of chromophores within skin tissue could be estimated correctly and robustly only when the bands were deliberately selected.
LncRNA SLC16A1‐AS1 contributes to the progression of hepatocellular carcinoma cells by modulating miR‐411/MITD1 axis
Authors: Duan Chun 
Published: March 2022

AbstractBackgroundHepatocellular carcinoma (HCC) is a common malignancy with high morbidity. The current study aimed to explore the molecular mechanism of lncRNA SLC16A1‐AS1 in the tumorigenesis of HCC.Material and methodsThe expression of SLC16A1‐AS1 and miR‐411 was examined in clinical HCC tissues. HCC cell lines Hep3B and Huh‐7 were employed and transfected with si‐SLC16A1‐AS1. The correlation between SLC16A1‐AS1 and miR‐411 was verified by luciferase reporter assay. Cell viability was detected by CCK‐8 assay. Cell migration and invasion capacity were examined by transwell assay. The protein level of MITD1 was analyzed by western blotting.ResultsThe expression of SLC16A1‐AS1 markedly increased in HCC tissues and cell lines. Subsequent studies identified SLC16A1‐AS1 as a downstream target of miR‐411. In addition, SLC16A1‐AS1 knockdown and miR‐411 overexpression significantly stagnated the progression of HCC cells. SLC16A1‐AS1 knockdown also downregulated MITD1 levels.ConclusionOur findings showed that SLC16A1‐AS1 was overexpressed in HCC cells and tissues. SLC16A1‐AS1 promoted the malignant characteristics of HCC cells and acted as an oncogene. Its regulatory effect may be associated with miR‐411/MITD1 axis. Therefore, SLC16A1‐AS1 has the potential to be used as a biomarker or therapeutic target for the treatment of HCC.
A multi‐omics‐based investigation of the immunological and prognostic impact of necroptosis‐related genes in patients with hepatocellular carcinoma
Authors: Yang Hang , Jiang QiNian 
Published: March 2022

AbstractBackgroundHepatocellular carcinoma (HCC) is the most common histological subtype of liver cancer and the third leading cause of death from cancer globally. Recent studies suggested cell death is also a key regulator of tumour progression. The purpose of this study was to generate a new predictive signature for HCC patients based on a complete analysis of necroptosis‐associated genes.MethodsWe extracted the mRNA expression profiles of HCC patients from the TCGA and ICGC databases and their clinical data. In addition, we used the IMvigor210 cohort to validate our model molecule's ability to predict the effect of immunotherapy. In the TCGA cohort, a seven‐gene risk‐prognostic model was constructed using univariate cox‐Lasoo regression. External validation was conducted using the ICGC cohort. The ssGSEA algorithm is used to determine the degree of immune function response. The CMAP databases are used for chemotherapy drug analysis and screening for drugs that reduce the expression of high‐risk genes. The cbioportal database was used to explore mutations in model genes.ResultsSurvival analysis shows shorter survival for high‐risk patients. Immune function analysis revealed significant differences in the activity of immune pathways between risk subgroups. Varied risk scores result in dramatically diverse immune infiltration and tumour growth, as well as significantly different chemotherapeutic sensitivity. In addition, Apigenin and LY‐294002 reduced the expression of high‐risk genes, while Arecoline had the opposite effect. In the immunotherapy IMvigor210 cohort, risk scores were significantly different between the objective responder and non‐responder groups. By comparing the models constructed with published literature, it is suggested that our model has better predictive power.ConclusionsWe created a new prognostic signature of necroptosis‐related genes that can be used as potential prognostic biomarkers to guide effective personalized therapy for hepatocellular carcinoma patients.
GSTT1, an increased risk factor for prostate cancer in patients with metabolic syndrome
Authors: Liu Dongdong , Che Bangwei , Chen Pan , He Jun , Mu Yi , Chen Kehang , Zhang Wenjun , Xu Shenghan , Tang Kaifa 
Published: March 2022

AbstractBackgroundGlutathione S‐transferase (GSTs) gene polymorphism and metabolic syndrome (Mets) are generally considered to be risk factors for prostate cancer (PCa). However, this conclusion is still controversial. There is a close relationship between GSTs gene polymorphism and Mets. We suspect that the effect of GSTs gene polymorphism and Mets on PCa may be the result of their joint action. As a result, the purpose of this study was to investigate the potential effect of GSTs gene polymorphism on PCa in patients with Mets.MethodsWe collected blood samples from 128 patients with PCa and 200 controls. The GSTs gene polymorphism was detected by polymerase chain reaction‐restriction fragment length polymorphism (PCR–RFLP). Age, characteristics of Mets, frequencies of GSTs gene polymorphism, total prostate volume (TPV), Gleason score, and prostate‐specific antigen (PSA) were recorded and analyzed.ResultsThere were significant differences in BMI, TG, LDL‐C, FBG, SBP, DBP, and HDL‐C among the control group, N‐PCa group, and Mets‐PCa group (p < 0.05). GSTT1 null genotype (OR = 2.844, 95% CI: 1.791–4.517), GSTM1 null genotype (OR = 2.192, 95% CI: 1.395–3.446), and GSTP1 (A/G + G/G) genotype (OR = 2.315, 95% CI: 1.465–3.657) were associated with PCa susceptibility and malignancy. Only the GSTT1 null genotype in Mets patients was positively correlated with PCa.ConclusionsOur study suggests that GSTs gene polymorphism may be a risk factor for PCa and can predict the susceptibility and malignancy of PCa. Secondly, in Mets patients, GSTT1 null genotype significantly increased the risk of PCa. GSTM1 null genotype and the effect of GSTP1 (AG + GG) on PCa were not significantly related to Mets.
The connectivity of the dual
Authors: Bokal Drago , Brinkmann Gunnar , Zamfirescu Carol T. 
Published: March 2022

AbstractThe dual of a polyhedron is a polyhedron—or in graph‐theoretical terms: the dual of a 3‐connected plane graph is a 3‐connected plane graph. Astonishingly, except for sufficiently large facewidth, not much is known about the connectivity of the dual on higher surfaces. Are the duals of 3‐connected embedded graphs of higher genus 3‐connected, too? If not, which connectivity guarantees 3‐connectedness of the dual? In this article, we give answers to some of these and related questions. We prove that there is no connectivity that guarantees the 3‐connectedness or 2‐connectedness of the dual for every genus, and give upper bounds for the minimum genus for which (with ) a c‐connected embedded graph with a dual that has a 1‐ or 2‐cut can occur. We prove that already on the torus, we need 6‐connectedness to guarantee 3‐connectedness of the dual and 4‐connectedness to guarantee 2‐connectedness of the dual. In the last section, we answer a related question by Plummer and Zha on orientable embeddings of highly connected noncomplete graphs.
Acute myeloid leukemia in SRP54‐mutated congenital neutropenia
Authors: Sabulski Anthony , Grier David D. , Myers Kasiani C. , Davies Stella M. , Rubinstein Jeremy D. 
Published: March 2022

AbstractSRP54 mutations have recently been implicated in congenital neutropenia (CN) and the in‐frame deletion, p.Thr117del, is the most common pathogenic mutation reported. The largest study of SRP54‐mutated CN to‐date followed 23 patients for a median of 15 years. No patients developed a hematologic malignancy in that study. Given the known risk of leukemia in other CNs it is crucial to know whether patients with SRP54‐mutated CN have an increased risk of leukemia. We report the first case of leukemia in a patient with SRP54‐mutated CN. A 15‐year‐old male with SRP54‐mutated CN (p.Thr117del) was diagnosed with acute myeloid leukemia with myelodysplasia‐related changes on a screening bone marrow evaluation. Next generation sequencing of the leukemia cells identified CSF3R and RUNX1 mutations. These mutations commonly co‐exist in CN‐associated malignancies and suggest leukemogenesis in SRP54‐mutated CN may occur in a similar manner to other CNs. He was successfully treated with CPX‐351 followed by hematopoietic cell transplant (HCT) and remains in remission at a follow‐up time of 9 months. Although conclusions from this single report must be limited, this has potentially significant implications for both screening and treatment practices for these patients, including the role and timing of HCT.
Microglial activation in Alzheimer's disease: The role of flavonoids and microRNAs
Authors: Medrano-Jiménez Elisa , Meza-Sosa Karla F , Urbán-Aragón José A , Secundino Ismael , Pedraza-Alva Gustavo , Pérez-Martínez Leonor 
Published: March 2022

AbstractAlzheimer's disease (AD) is the most common form of senile dementia and is characterized by progressive cognitive impairment and neuronal degeneration. Microglial activation is an important pathologic hallmark of AD. During disease progression, microglial cells switch from an alternative or anti-inflammatory and neuroprotective profile (M2) to a classic or proinflammatory and neurotoxic profile (M1). Phenotypically, M1 microglia is characterized by the activation of inflammatory signaling pathways that cause increased expression of proinflammatory genes, including those coding for cytokines and chemokines. This microglia-mediated neuroinflammation contributes to neuronal cell death. Recent studies in microglial cells have shown that a group of plant-derived compounds, known as flavonoids, possess anti-inflammatory properties and therefore exert a neuroprotective effect through regulating microglia activation. Here, we discuss how flavonoids can promote the switch from an inflammatory M1 phenotype to an anti-inflammatory M2 phenotype in microglia and how this represents a valuable opportunity for the development of novel therapeutic strategies to blunt neuroinflammation and boost neuronal recovery in AD. We also review how certain flavonoids can inhibit neuroinflammation through their action on the expression of microglia-specific microRNAs (miRNAs), which also constitute a key therapeutic approach in different neuropathologies involving an inflammatory component, including AD. Finally, we propose novel targets of microglia-specific miRNAs that may be considered for AD treatment.
DyNAMiC: A prospective longitudinal study of dopamine and brain connectomes: A new window into cognitive aging
Authors: Nordin Kristin , Gorbach Tetiana , Pedersen Robin , Panes Lundmark Vania , Johansson Jarkko , Andersson Micael , McNulty Charlotte , Riklund Katrine , Wåhlin Anders , Papenberg Goran , Kalpouzos Grégoria , Bäckman Lars , Salami Alireza 
Published: March 2022

AbstractConcomitant exploration of structural, functional, and neurochemical brain mechanisms underlying age‐related cognitive decline is crucial in promoting healthy aging. Here, we present the DopamiNe, Age, connectoMe, and Cognition (DyNAMiC) project, a multimodal, prospective 5‐year longitudinal study spanning the adult human lifespan. DyNAMiC examines age‐related changes in the brain’s structural and functional connectome in relation to changes in dopamine D1 receptor availability (D1DR), and their associations to cognitive decline. Critically, due to the complete lack of longitudinal D1DR data, the true trajectory of one of the most age‐sensitive dopamine systems remains unknown. The first DyNAMiC wave included 180 healthy participants (20–80 years). Brain imaging included magnetic resonance imaging assessing brain structure (white matter, gray matter, iron), perfusion, and function (during rest and task), and positron emission tomography (PET) with the [11C]SCH23390 radioligand. A subsample (n = 20, >65 years) was additionally scanned with [11C]raclopride PET measuring D2DR. Age‐related variation was evident for multiple modalities, such as D1DR; D2DR, and performance across the domains of episodic memory, working memory, and perceptual speed. Initial analyses demonstrated an inverted u‐shaped association between D1DR and resting‐state functional connectivity across cortical network nodes, such that regions with intermediate D1DR levels showed the highest levels of nodal strength. Evident within each age group, this is the first observation of such an association across the adult lifespan, suggesting that emergent functional architecture depends on underlying D1DR systems. Taken together, DyNAMiC is the largest D1DR study worldwide, and will enable a comprehensive examination of brain mechanisms underlying age‐related cognitive decline.