bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple Congenital Anomalies: Meningoencephalocele, Labiopalatoschisis and Clubfoot with Normal Chromosomal Analysis
Authors: Samosir Sefty M. , Rachmiawaty Angghea , Fatati Ita , Aziz Alamsyah 
Published: July 2022

Objective : To perform chromosomal microarray when similar case was found.Methods: Case reportCase : G1P0A0, 20 years-old, 23-24 weeks gestation, normal BMI, was diagnosed by ultrasonography with multiple congenital anomaly consisted by meningoencephalocele, labiopalatoschisis, and clubfoot. Amniocentesis was performed to manage karyotyping analysis and a result of 46 XY was obtained. Neonate was delivered with exact condition according to prenatal diagnosis and was demised 6 hours postnatal. Patient had no history of smoking or DM, and no familial congenital deformity. Patient was a worker in textile manufactory and inadequacy folic acid intake during pregnancy was known.Early suspicion of aneuploidy as cause of multiple congenital anomalies in this case was not proven otherwise. Serology test also found no congenital infection. Literature research indicated tendency of MTHFR polymorphisms. Genetic analysis such as chromosomal microarray to establish involvement of MTHFR polymorphism is needed.Conclusion : This case should behold as clinicians’ consideration to perform additional examination and patients counseling when similar anomaly was found during prenatal ultrasonography examination.Keyword : chromosomal microarray,karyotyping; MTHFR polymorphism, mutiple congenital anomaly.

Abstrak
Tujuan : Untuk melakukan pemeriksaan chromosomal microarray pada kasus yang sama.Metode: Laporan kasus.Kasus : G1P0A0, usia 20 tahun, hamil 23-24 minggu, didiagnosis secara ultrasonografi dengan kelainan kongenital multipel berupa meningoensefalokel, celah bibir-palatum, dan club foot. Amniosentesis dilakukan pada pasien untuk analisis kromosom dan didapatkan hasil 46 XY. Bayi lahir dengan kondisi yang sama dengan diagnosis prenatal tersebut dan meninggal 6 jam pasca salin. Dari hasil anamnesis dan pemeriksaan kami dapatkan pasien bukan perokok, tidak ada keluarga dengan cacat bawaan, indeks masa tubuh pasien normal. Pasien merupakan karyawan pabrik tekstil dan pasien tidak mengkonsumsi asam folat adekuat selama kehamilan. Dua data terakhir yang kemungkinan berkontribusi terjadinya kelainan kongenital multipel pada kasus ini, yaitu kontak dengan teratogen dan defisiensi asam folat. Dugaan awal kelainan kromosom sebagai penyebab kelainan kongenital multipel pada kasus ini tidak terbukti. Sayangnya, investigasi-investigasi lebih lanjut berupa analisis genetik, seperti pemeriksaan apakah terdapat polimorfisme MTHFR yang berhubungan dengan defisiensi asam folat pada kasus ini tidak dilakukan karena keluarga pasien menolak. Kesimpulan : Kasus ini sebaiknya menjadi bahan pertimbangan klinisi untuk melakukan pemeriksaan tambahan dan edukasi ke pasien pada saat menemukan kelainan yang sama pada pemeriksaan ultrasonografi prenatal.Keyword: chromosomal microarray; karyotyping; multipel kongenital anomali; polimorfisme MTHFR
Progress of Labor Onset with Combination of Pregnancy Massage and Acupressure
Authors: Khanifah Milatun , Nur Chabibah , Khuzaiyah Siti 
Published: July 2022

Abstract
Objective: To investigate effectiveness of complementary therapy combination pregnancy massage and acupressure on the onset of labor in primigravida pregnant women.
Methods: The population was pregnant women in all regions of Pekalongan Regency at more than 39 weeks' gestation, using random cluster sampling. Data collect use an observation sheet to measure the start time of labor and also check the implementation of massage and acupressure in pregnancy. Treatment was carried out every 2-3 days from 39 weeks of gestation until labor occurs. This study was quantitative quasi-experimental with control group design with a cohort approach.
Results: The results of the bivariate analysis showed that there were significant differences in the onset of childbirth in the intervention group with the control group (p-value; 0.003; CI -8.59 - (- 2.07)). It was concluded that complementary therapy combined therapy of pregnancy massage and acupressure could be used as an alternative therapy to prevent overdue pregnancy
Conclusions: These findings confirm that complementary therapy combination pregnancy massage and acupressure could faster the onset of labor.
Keywords: acupressure, complementary therapy, onset labor, pregnancy massage.

Abstrak
Tujuan: Untuk mengetahui efektivitas terapi komplementer kombinasi pijat kehamilan dan akupresur pada permulaan persalinan pada ibu hamil primigravida.
Metode: Populasi dalam penelitian ini adalah ibu hamil di seluruh wilayah Kabupaten Pekalongan dengan usia kehamilan lebih dari 39 minggu, dengan menggunakan sampel cluster random. Pengumpulan data menggunakan lembar observasi untuk mengukur waktu mulai persalinan serta memeriksa pelaksanaan pijat dan akupresur pada kehamilan. Pengobatan dilakukan setiap 2-3 hari dari usia kehamilan 39 minggu sampai terjadi persalinan. Penelitian ini merupakan penelitian kuasi eksperimental kuantitatif dengan desain kelompok kontrol dengan pendekatan kohort.
Hasil: analisis bivariat menunjukkan terdapat perbedaan yang signifikan timbulnya persalinan pada kelompok intervensi dengan kelompok kontrol (p-value; 0,003; CI -8,59 - (- 2,07)). Disimpulkan bahwa terapi komplementer terapi kombinasi pijat kehamilan dan akupresur dapat digunakan sebagai terapi alternatif untuk mencegah terjadinya kehamilan terlambat.
Kesimpulan: Temuan ini mengkonfirmasi bahwa terapi komplementer kombinasi pijat kehamilan dan akupresur dapat mempercepat terjadinya persalinan.
Kata kunci: akupresur; awalan persalinan, pijat kehamilan ,terapi komplementer.
The Role Placental TLR-7 Expression with Cord Blood HBV DNA and Placental HBV DNA
Authors: Naeny Fajriah  , Chalid Maisuri T. , Lisal Lenny , Lukas Efendi , St. Nur Asni  , Rina Masadah  
Published: July 2022

Abstract
Objective: To determine the role of TLR-7 expression on intrauterine vertical transmission in pregnancy through identification of serum hepatitis B markers in both maternal and umbilical cord blood.
Methods: Analysis of TLR expression was performed on 38 paraffin block samples of placental tissue acquired from mothers with HBV using TLR immunohistochemical staining.
Results: 16 of 38 samples were acquired from mothers aged 26-30 years-old. Most of the samples were from primiparous mothers (52.6%). This study found no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood (p = 1.000). However, we found a significant association between placental TLR-7 expression and maternal HBV DNA (p = 0.034). Meanwhile, placental HBeAg and HBV DNA were not associated with placental TLR-7 expression (p = 0.082; p = 1.000).
Conclusion: There was no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood, but we found a significant association between TLR-7 expression and maternal HBV DNA.
Keywords: HBV DNA, Hepatitis B, intrauterine infection, placental toll-like receptor (TLR) 7,umbilical cord.

Abstrak
Tujuan: untuk melihat peran ekspresi TLR-7 terhadap transmisi vertikal intrauterina pada kehamilan melalui identifikasi marker serum hepatitis B pada darah ibu dan talipusar.
Metode: Analisis ekspresi TLR dilakukan pada 38 sampel blok paraffin jaringan plasenta ibu yang menderita HBV dengan memakai pewarnaan imuhohistokimia TLR.
Hasil: 16 dari 38 sampel berusia 26-30 tahun. Sebagian besar sampel merupakan kelompok primipara (52.6%). Penelitian ini tidak menemukan hubungan yang signifikan antara ekspresi TLR-7 di plasenta dan HBV DNA darah tali pusat (p = 1.000). Tapi, kami menemukan hubungan yang signifikan antara ekspresi TLR-7 plasenta dan HBV DNA ibu (p = 0,034). Sedangkan HBeAg dan HBV DNA plasenta tidak berhubungan dengan ekspresi TLR-7 plasenta (p = 0,082; p = 1.000).
Kesimpulan: Tidak ada hubungan yang signifikan antara ekspresi TLR-7 dan DNA HBV di plasenta dan tali pusat, tetapi kami menemukan hubungan yang signifikan antara ekspresi TLR-7 dan DNA HBV ibu.
Kata kunci: HBV DNA, Hepatitis B, infeksi intrauterina, plasenta, tali pusat, toll-like receptor (TLR) 7
Vaginal Microorganism Pattern in Premature Rupture of Membrane
Authors: Vanya vanesha  , Wantania John J. E , Lengkong Rudy A. 
Published: July 2022

Objective: To determine the pattern of vaginal microorganisms in pregnant women and risk factors for premature rupture of membranes (PROM) in Manado.Methods: This is a case-control study. Samples was 40, divided into 20 pregnant with PROM and 20 control samples. Samples were taken from Kandou Manado Hospital and network hospitals within the inclusion criteria. Samples were taken from vaginal swab for microorganism culture.Results: The highest age distribution in the case of PROM was in the reproductive age group of 20-35 years, 19 people (95%, p = 1,000). Primiparas were dominant in the PROM were 11 people (55%, p = 0.204). The distribution of BMI mostly from the overweight and obesity groups of 11 people (55%, p = 0.527). In the PROM, 19 people (95%, p = 0.605) did not smoke. Escherichia coli was the most microorganisms in swab vaginal of PROM: 7 people (29.17%).Conclusion: The most microorganisms found in PROM are Escherichia coli, Enterobacter cloacae and Staphyloccocus aureus and in non-PROM are Klebsiella oxytoca, Staphylococcus epidermidis, Staphylococcus saprophyticus and Pseudomonas fluorescens. There was no relationship between BMI, age, parity, smoking, and gestational age with the incidence of PROM in this study.Keywords: PROM , vaginal microorganisms pattern, vaginal swab.

Abstrak
Tujuan: Untuk mengetahui pola mikroorganisme vagina pada kultur vaginal swab wanita hamil dan faktor risiko pada KPD di Kota Manado.Metode : Studi ini bersifat case control. Total sampling 40 sampel dibagi menjadi 20 sampel hamil dengan KPD dan 20 kontrol. Sampel diambil dari RSUP Kandou Manado dan RS jejaring yang memenuhi kriteria inklusi. Semua pasien dilakukan pengambilan sampel swab vagina untuk dilakukan kultur mikroorganisme.Hasil : Hasil sebaran usia pada KPD paling banyak pada usia reproduksi 20-35 tahun yaitu 19 orang (95%, p = 1,000). Primipara dominan pada KPD yaitu 11 orang (55%, p = 0,204). Hasil sebaran IMT paling banyak kelompok overweight dan obesitas yaitu 11 orang (55%, p = 0,527). Pada KPD sebanyak 19 orang (95%, p = 0,605) tidak merokok. Mikroorganisme terbanyak pada swab vagina KPD adalah Escherichia coli sebanyak 7 orang (29,17%). Kesimpulan: Mikroorganisme terbanyak pada KPD adalah Escherichia coli, Enterobacter cloacae dan Staphyloccocus aureus dan pada non KPD adalah Klebsiella oxytoca, Staphylococcus epidermidis, Staphylococcus saprophyticus dan Pseudomonas fluorescens. Tidak ada hubungan antara IMT, usia, paritas, merokok, dan umur kehamilan dengan kejadian KPD pada penelitian ini.Kata kunci: pola mikroorganisme vagina, ketuban pecah dini, swab vagina.
АНАЛІЗ ІСНУЮЧИХ СИСТЕМ ОЦІНЮВАННЯ ВІЙСЬКОВО-СЛУЖБОВЦІВ В АРМІЯХ ФРАНЦІЇ, ВЕЛИКОБРИТАНІЇ, США
Authors: Рибидайло Анатолій , Прокопенко Олександр , Уварова Тетяна , Руденська Галина , Цимбал Ірина 
Published: July 2022

Оцінювання (атестація) особового складу є невід’ємною процедурою формування кар’єри військовослужбовця. Підґрунтям для здійснення організаційно-штатних заходів є результати оцінювання військовослужбовців. У статі наведено аналіз існуючих систем оцінювання військовослужбовців в арміях Франції, Великобританії та США для визначення прийнятних практик щодо впровадження у діяльність кадрових органів Збройних Сил України.
Досліджено порядок, терміни і основні критерії оцінювання особового складу та проаналізовано особливості кадрового менеджменту стосовно прийняття військовослужбовців на службу, їх підготовки, призначення на посади (використання на посаді), подальшого розвитку, мотивації та виходу у відставку або завершення служби.
ПІДХОДИ ТА МЕТОДИ TALENT MANAGEMENT У СТРАТЕГІЇ УПРАВЛІННЯ КАДРОВИМИ РЕСУРСАМИ ЗБРОЙНИХ СИЛ УКРАЇНИ
Authors: Цевельов Олег , Оліферук Володимир , Кітура Олег 
Published: July 2022

Система управління талантами (Talent management system, TMS) – це інтегрований програмний продукт, який представляє автоматизовані інструменти для вирішення завдань в чотирьох ключових областях: підбор и залучення; управління ефективністю; навчання та розвиток; а також формування заходів заохочення та популяризації. У цій системі під час планування кар’єри потрібно враховувати наступне, а саме – які навички та вміння потрібні кандидату в майбутньому, а не лише зараз. Адже успіх розвитку військового колективу значною мірою залежить не тільки від високого рівня готовності й умінь діяти в бойовій обстановці, а й від ефективності використання особистих якостей військовослужбовців, які є рушійною силою будь-якого військового підрозділу та важливим складником досягнення їм високих позицій з виконання поставлених завдань та результативності підрозділу і військового колективу у цілому.
На сьогодні існують масштабні автоматизовані продукти для планування кар’єри, розроблені з урахуванням необхідності постійного моніторингу та оцінки кандидатів на ключові позиції на проміжних етапах. Але таку систему потрібно побудувати самостійно саме для Збройних Сил України та інших військових формувань враховуючи їх досвід формування, підготовки, оснащеності та внутрішньої культури військових колективів й укладу життя. Отже, виникає потреба побудови нової системи управління персоналом, основою якої стане орієнтація на таланти, оскільки управління талантами (Talent Management) – це повний спектр кадрових процесів для залучення, адаптації, розвитку, мотивації та утримання високоефективних спеціалістів у військовій сфері. Управління талантами спрямоване на підвищення ефективності військових процесів за допомогою тренувань і практики (навчань), які роблять особовий склад підрозділу більш продуктивним та цілісним.
Flaw Detection in White Porcelain Wine Bottles Based on Improved YOLOv4 Algorithm
Authors: Gong Guoqiang , Huang Jun , Wang Hemin 
Published: July 2022

Aiming at the problems of low detection accuracy and slow detection speed in white porcelain wine bottle flaw detection, an improved flaw detection algorithm based on YOLOv4 was proposed. By adding Coordinate Attention to the backbone feature extraction network, the extracting ability of white porcelain bottle flaw features was improved. Deformable convolution is added to locate flaws more accurately, so as to improve the detection accuracy of flaws by the model. Efficient Intersection over Union was used to replace Complete Intersection over Union in YOLOv4 to improve the loss function and improve the model detection speed and accuracy. Experimental results on the surface flaw data set of white porcelain wine bottles show that the proposed algorithm can effectively detect white porcelain wine bottle flaws, the mean Average Precision of the model can reach 92.56%, and the detection speed can reach 37.17 frames/s.
Analysis of Clinical Features and Risk Factors in Pregnant Women With Miliary Pulmonary Tuberculosis After In Vitro Fertilization Embryo Transfer
Authors: Dong Siyuan , Zhou Ruoyu , Peng Emin , He Ruoxi 
Published: July 2022

PurposeMiliary pulmonary tuberculosis (TB) among pregnant women after in vitro fertilization embryo transfer (IVF-ET) causes poor outcomes but is rarely reported. This study analyzed the clinical characteristics and risk factors of these patients to provide hints for further studies.MethodThe demographic characteristics, clinical manifestations, radiologic features, treatment, and outcomes of six patients diagnosed from May 2012 to August 2021 in Xiangya Hospital and 69 patients that were reported in English or Chinese literature from January 1980 to August 2021 were retrospectively analyzed. Continuous variables were compared between groups by t-test or Mann–Whitney U test, and categorical variables were compared between groups by chi-square test or Fisher exact test. Univariate and multiple logistic regression analyses were used to determine the predictors of respiratory failure.ResultsA total of 75 patients were included. The average age of patients was about 30 years. All patients had tubal obstruction; 5 of them were diagnosed with pelvic TB before. Thirteen cases had a history of pulmonary or extrapulmonary TB, six out of them without any antituberculosis treatment history. All patients were in their first or second trimester during the onset of symptoms. The average interval between onset of symptoms and radiologic examination was about 21 days. The most common abnormalities on chest computed tomography scan were multiple nodules, pulmonary infiltrate, and consolidation. Merely 10 patients obtained bacteriological diagnosis by Mycobacterium tuberculosis culture or polymerase chain reaction test. The other patients were clinically diagnosed. All the patients received antituberculosis treatment. Although 44% of patients had fatal complications, all cases were cured or improved after antituberculosis treatment. Unfortunately, only eight fetuses survived (10.6%). The most frequent and severe complication was type I respiratory failure (20%). Patients with expectoration, dyspnea, coarse breath sounds, ground-glass opacity, and pulmonary infiltrate or consolidation were more likely to have respiratory failure (P &lt; 0.05). Ground-glass opacity (OR = 48.545, 95% CI = 2.366–995.974, P = 0.012) and pulmonary infiltrate or consolidation (OR = 19.943, 95% CI = 2.159–184.213, P = 0.008) were independent predictors for respiratory failure.ConclusionTube infertility with underscreened or untreated TB is a risk factor for miliary TB during pregnancy after IVF-ET. Ground-glass opacity and pulmonary infiltrate or consolidation are predictors of respiratory failure. We demonstrate risk factors for incidence and complications to supply clues for future intervention and improve patient prognosis.
Chinese Herbal Medicine Reduces the Risk of Heart Failure in Hypertensive Patients: A Nationwide, Retrospective, Cohort Study
Authors: Liu Chun-Ting , Hung I-Ling , Hsu Chung Y. , Hu Kai-Chieh , Chen Yung-Hsiang , Tsai Ming-Yen 
Published: July 2022

BackgroundHypertension (HTN) is the leading preventable risk factor for cardiovascular disease worldwide. Patients with HTN are at higher risk for heart failure (HF). The currently available therapeutic approaches for HTN do not always optimally control blood pressure or are not suitable for hypertensive patients who have a higher number of comorbidities. This study aimed to determine whether Chinese herbal medicine (CMH)-based interventions could reduce the risk of HF in hypertensive patients.MethodsThis retrospective study randomly selected 2 million enrollees from the National Health Insurance Research Database and identified 507,608 patients who were newly diagnosed with HTN in 2000–2017. After 1:1 frequency-matching by age, sex, index year, income, urbanization, duration of HTN, comorbidities and antihypertensive medications, we selected 8,912 eligible patients in each group. During 16 years of follow-up, 380 CHM users and 426 CHM non-users developed HF, representing incidence rates of 6.29 and 7.43 per 1,000 person-years, respectively.ResultsCHM users had significantly lower HF risk compared with CHM non-users (adjusted HR = 0.85, 95% CI 0.74–0.98). The markedly predominant effect was observed in those receiving CHM products for more than 180 days (adjusted HR = 0.65). The frequently prescribed formula, Jia-Wei-Xiao-Yao-San, and the single herbs Ge Gen, Huang Qi, Du Zhong, Huang Qin, and Chuan Xiong were significantly associated with lower risk of HF.ConclusionsThis population-based study revealed decreased HF risk in hypertensive patients with CHM use. These findings may provide a reference for HF prevention strategies and support the integration of CHM into clinical intervention programs that provide a favorable prognosis for hypertensive patients.
Smartwatch-Based Blood Pressure Measurement Demonstrates Insufficient Accuracy
Authors: Falter Maarten , Scherrenberg Martijn , Driesen Karen , Pieters Zoë , Kaihara Toshiki , Xu Linqi , Caiani Enrico Gianluca , Castiglioni Paolo , Faini Andrea , Parati Gianfranco , Dendale Paul 
Published: July 2022

BackgroundNovel smartwatch-based cuffless blood pressure (BP) measuring devices are coming to market and receive FDA and CE labels. These devices are often insufficiently validated for clinical use. This study aims to investigate a recently CE-cleared smartwatch using cuffless BP measurement in a population with normotensive and hypertensive individuals scheduled for 24-h BP measurement.MethodsPatients that were scheduled for 24-h ambulatory blood pressure monitoring (ABPM) were recruited and received an additional Samsung Galaxy Watch Active 2 smartwatch for simultaneous BP measurement on their opposite arm. After calibration, patients were asked to measure as much as possible in a 24-h period. Manual activation of the smartwatch is necessary to measure the BP. Accuracy was calculated using sensitivity, specificity, positive and negative predictive values and ROC curves. Bland-Altman method and Taffé methods were used for bias and precision assessment. BP variability was calculated using average real variability, standard deviation and coefficient of variation.ResultsForty patients were included. Bland-Altman and Taffé methods demonstrated a proportional bias, in which low systolic BPs are overestimated, and high BPs are underestimated. Diastolic BPs were all overestimated, with increasing bias toward lower BPs. Sensitivity and specificity for detecting systolic and/or diastolic hypertension were 83 and 41%, respectively. ROC curves demonstrate an area under the curve (AUC) of 0.78 for systolic hypertension and of 0.93 for diastolic hypertension. BP variability was systematically higher in the ABPM measurements compared to the smartwatch measurements.ConclusionThis study demonstrates that the BP measurements by the Samsung Galaxy Watch Active 2 show a systematic bias toward a calibration point, overestimating low BPs and underestimating high BPs, when investigated in both normotensive and hypertensive patients. Standards for traditional non-invasive sphygmomanometers are not met, but these standards are not fully applicable to cuffless devices, emphasizing the urgent need for new standards for cuffless devices. The smartwatch-based BP measurement is not yet ready for clinical usage. Future studies are needed to further validate wearable devices, and also to demonstrate new possibilities of non-invasive, high-frequency BP monitoring.