bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with changes in illicit opioid use during the COVID-19 pandemic among incarcerated people who use drugs in Quebec, Canada
Authors: Park Hyejin , Linthwaite Blake , Dussault Camille , Halavrezos Alexandros , Chalifoux Sylvie , Sherman Jessica , Del Balso Lina , Buxton Jane A. , Cox Joseph , Kronfli Nadine 
Published: December 2022

Purpose
People who use drugs (PWUD) have been disproportionately affected by the COVID-19 pandemic. This study aims to examine changes in illicit opioid use and related factors among incarcerated PWUD in Quebec, Canada, during the pandemic.

Design/methodology/approach
The authors conducted an observational, cross-sectional study in three Quebec provincial prisons. Participants completed self-administered questionnaires. The primary outcome, “changes in illicit opioid consumption,” was measured using the question “Has your consumption of opioid drugs that were not prescribed to you by a medical professional changed since March 2020?” The association of independent variables and recent changes (past six months) in opioid consumption were examined using mixed-effects Poisson regression models with robust standard errors. Crude and adjusted risk ratios with 95% confidence intervals (95% CIs) were calculated.

Findings
A total of 123 participants (median age 37, 76% White) were included from January 19 to September 15, 2021. The majority (72; 59%) reported decreased illicit opioid consumption since March 2020. Individuals over 40 were 11% less likely (95% CI 14–8 vs 18–39) to report a decrease, while those living with others and with a history of opioid overdose were 30% (95% CI 9–55 vs living alone) and 9% (95% CI 0–18 vs not) more likely to report decreased illicit opioid consumption since March 2020, respectively.

Originality/value
The authors identified possible factors associated with changes in illicit opioid consumption among incarcerated PWUD in Quebec. Irrespective of opioid consumption patterns, increased access to opioid agonist therapy and enhanced discharge planning for incarcerated PWUD are recommended to mitigate the harms from opioids and other drugs.
Managing unbounded digital transformation: exploring the role of tensions in a digital transformation initiative in the forestry industry
Authors: Koukouvinou Panagiota , Simbi Nadia , Holmström Jonny 
Published: December 2022

PurposePrior research has highlighted the pervasive importance of digital technologies in business and societal settings, but their enabling role in digital transformation, and effective forms of organization to address tensions that arise during attempts to promote it, have been insufficiently explored. Therefore, the purpose of this paper is to investigate how and why tensions affect clusters established to foster digital transformation.Design/methodology/approachEmpirical data were acquired through a qualitative exploratory holistic single case study, focused on the Swedish Cluster of Forest Technology. This included interviews with informants, selected by homogeneous purposive sampling, and event observation to investigate the personal perspectives of representatives of every company engaged in the cluster, followed by a thematic analysis of their comments.FindingsThe case study revealed three major tensions, between knowledge flow, collaboration and competition, but also others that were interrelated with those major tensions, related to matters such as trust and protection of intellectual property, power equality and hierarchy, and networks that must be managed in digital transformation efforts.Originality/valueThe paper extends understanding of the tensions that arise, and their management, in digital transformation processes.
An investigation into how value incongruence became misfit
Authors: Sun Yuwei , Billsberry Jon 
Published: December 2022

Purpose
The purpose of this review is to argue that the way that perceived employee misfit (PEM) has been measured in quantitative studies does not capture the construct identified in qualitative studies.

Design/methodology/approach
Through reverse citation analysis, this study reveals how low levels of value congruence became the currency of PEM in quantitative studies.

Findings
This study finds that in the absence of alternatives, researchers have taken low scores of value congruence as a measure of misfit. However, there is limited evidence to show that PEM relates to values, supplementary conceptualization or interactions with the organization (rather than interactions with other employees, tasks, etc.). In addition, the most commonly used instruments measure degrees of similarity, not disparity, making the interpretation of PEM-related data unclear. Combined, these factors raise construct validity concerns about most quantitative studies of PEM.

Research limitations/implications
Given the upsurge of interest in PEM, there is an urgent need for greater clarification on the nature of the construct. From the analysis, this study identifies two key dimensions of studying PEM that create four distinctly different ways of conceptualizing the construct.

Originality/value
This study highlights a series of major methodological weaknesses in the study of PEM and reveal that almost all published quantitative studies of PEM are actually studying something else; something whose nature is very unclear.
Is Ramadan model of intermittent fasting related to hedonic hunger?
Authors: Tengilimoglu-Metin M. Merve , METİN Ziya Erokay 
Published: December 2022

Purpose
The purpose of this study was to examine hedonic hunger at the end of the Ramadan fasting.

Design/methodology/approach
Data were collected by the Power of Food Scale (PFS), Food Craving Questionnaire-Trait (FCQ-T) and the Visual Analogue Scale. All data were taken twice at the beginning and end of Ramadan fasting.

Findings
A total number of 105 volunteers (43.8% female and 56.2% male) participated in a cross-sectional study. Ramadan fasting associated with PFS food tasted sub-factor, whereas no association was found on PFS aggregate and other PFS domain factors. Participants had higher PFS food tasted domain score at the end of the Ramadan fasting than before Ramadan fasting (p < 0.001). Total FCQ-T score as well as all sub-domains did not differ significantly. Females desired to consume carbonated beverages more, whereas in male (p = 0.04), ice cream was the most craved food.

Originality/value
The findings of this study provide data to the literature about the relation between Ramadan fasting and hedonic hunger. Ramadan fasting appears to have an influence on pleasure at first bite. The effect of Ramadan fasting on hedonic hunger should be tested with larger samples and controlled trials.
(Re)constructing performative anti-racist education courses: from the experiences of Black feminist graduate assistants
Authors: Adeniji Danelle , Foster Marquita 
Published: December 2022

PurposeThe purpose of this study is to describe the authors’ experiences as Black feminist graduate assistants assigned to teach diversity courses led by white professors.Design/methodology/approachThe authors draw from Black feminist approach to provide authentic, liberatory anti-racist pedagogy, ensuring that the identities and cultural knowledge of Black, indigenous and people of color (BIPOC) pre-service teachers (PSTs) are given space in anti-racist education and social studies courses.FindingsThe study’s findings show that creating systems for (re)constructing performative anti-racist courses disrupt whiteness and whitewashed pedagogy in teacher preparation programs.Originality/valueThe implications of the authors’ experiences reflect that centering abolitionist teaching methods can bolster BIPOC PSTs anti-racist identities and future practices in diverse classrooms.
Genome size does not influence extinction risk in the world's amphibians
Authors: Pincheira‐Donoso Daniel , Harvey Lilly P. , Johnson Jack V. , Hudson Dave , Finn Catherine , Goodyear Luke E. B. , Guirguis Jacinta , Hyland Edel M. , Hodgson Dave J. 
Published: December 2022

AbstractVariation in genome size spans multiple orders of magnitude among animals. Despite the longstanding debate regarding the adaptive value or costs of genomic complexity, genome size has been proposed to influence extinction risk under the rapidly changing environments of the Anthropocene.The main hypothesis suggests that genome enlargement increases the accumulation of deleterious mutations while reducing rates of organismal growth and development. These combined effects of larger genome size are predicted to trigger population declines that can lead to extinction, especially under rapidly changing environments that disrupt demographic resilience.Comparative evidence from terrestrial plants and across vertebrates has provided mixed support for this hypothesis. However, large‐scale comparative studies based on explicit phylogenetic approaches remain lacking. Using a global‐scale amphibian dataset and two recognised proxies of extinction risk (International Union for Conservation of Nature IUCN conservation categories and population trends), we test the prediction that genomes are larger (as estimated by C‐value) in species facing extinction risk. We combine these analyses with life‐history traits widely known to be implicated with extinctions (body size, fecundity), along with a range of environmental factors.Our phylogenetic analyses consistently failed to identify an effect of genome size on either of the two proxies for extinction risk. The only consistent predictor of extinction risk observed across models performed for amphibians combined and for orders separately was decreasing geographical range size. We also identified a role for larger body size, decreasing range of environmental temperature (for anurans) and increasing levels of UV‐B radiation (for salamanders) as drivers of increasing threat.Our study provides no support for the prediction that species with larger genomes suffer heightened risk of extinction. We discuss some fundamental limitations underlying the genome size‐extinction hypothesis, and suggest that it is not a promising avenue to elucidate the causes of biodiversity declines in the Anthropocene.Read the freePlain Language Summaryfor this article on the Journal blog.
A pattern recognition receptor C‐type lectin TcCTL14 contributes to immune response and development in the red flour beetle, Tribolium castaneum
Authors: Zhang Yonglei , Ai Huayi , Wang Yihan , Zhang Ping , Du Liheng , Wang Jiatao , Wang Suisui , Gao Han , Li Bin 
Published: December 2022

AbstractEvidence is accumulating that pattern recognition receptor (PRR) C‐type lectins (CTL) play essential roles in recognition of pathogens. TcCTL14 (accession no. TC00871) contains the most domains among all CTL of Tribolium castaneum. Yet the biological function of TcCTL14 remains unclear. In this study, TcCTL14 exhibiting typical motif and domain of CTL was cloned from T. castaneum. The expression pattern analysis showed that TcCTL14 was highly expressed in late pupae and central nervous system, and was upregulated after treatment with Escherichia coli and Staphylococcus aureus, respectively. Analysis of binding affinity revealed that recombinant TcCTL14 not only could bind to lipopolysaccharide and peptidoglycan in a dose‐dependent fashion, but possibly could bind to and agglutinate different bacteria in a Ca2+‐dependent fashion. Knockdown of TcCTL14 before injection with bacteria led to the downregulation of nuclear factor‐κB transcription factors of Toll/IMD and 4 antimicrobial peptides. Knockdown of TcCTL14 also caused suppressed metamorphosis, reduced fecundity, and delayed embryogenesis of T. castaneum. Further observation discovered that knockdown of TcCTL14 inhibited the development of ovaries and embryos. The detection of signaling pathways revealed that TcCTL14 may be involved in metamorphosis and fecundity by impacting 20‐hydroxyecdysone and vitellogenin, respectively. Overall, these results indicate that TcCTL14 may contribute to immune response by agglutination or regulating the expression of antimicrobial peptides by the Toll/IMD pathway, and is required for T. castaneum development including metamorphosis, fecundity, and embryogenesis. These findings will improve the functional cognition of PRR CTL in insects and provide the new strategy for pest control.
Genomic differentiation with isolation by distance along a latitudinal gradient in the spotted‐leg treefrogPolypedates megacephalus
Authors: JIN Long , ZHENG Yuchi , LUAN Xiaofeng , LIAO Wenbo 
Published: December 2022

AbstractThe patterns of isolation by distance (IBD) entailing increased genetic differentiation among populations have aroused extensive concerns for evolutionary biologists. Although the IBD may act on spatial processes contributing to the genetic differentiation among populations in anuran species, the factors shaping the IBD of frogs among populations in natural systems are largely unknown. Here, we studied the genetic differentiation among six populations with 24 individuals of the spotted‐leg treefrog along a latitudinal gradient (1860.31 km) based on 1020 single nucleotide polymorphisms from restriction site‐associated DNA sequencing. The results showed that the genetic diversity differed significantly among populations and that the insular populations had higher genetic diversity than the mainland populations. Furthermore, we also found a significant genetic differentiation among populations (FST= 0.277) and no sign of inbreeding (FUNI= −0.145). The IBD was detected for all populations, and a higher degree of the IBD was indicated when controlling for the effects of the isolation between Hainan and mainland populations caused by the Qiongzhou Strait. Our findings suggest that the form of the Qiongzhou Strait plays a key role in shaping the genetic diversity and population differentiation in treefrogs.
Screening of dephytinization reaction of chlorophyll pigments with citrus acetone powder by UPLC–DAD–MS
Authors: Li Yunchang , Agarry Israel Emiezi , Ding Desheng , Zalán Zsolt , Huang Pimiao , Cai Tian , Chen Kewei 
Published: December 2022

AbstractThe preparation of dephytylated chlorophyll standards is inefficient and the process is complicated, which hinders chlorophyll determination and related bioactive property investigation. In this paper, chlorophyll derivatives from four phytylated chlorophylls (chlorophyll a, chlorophyll b, pheophytin a, and pheophytin b) before and after the enzymatic reaction were qualitatively and quantitatively characterized by UPLC–DAD–MS. A simple index was proposed to characterize chlorophyll pigments from their oxidized counterparts by the λmax of the typical peak of chlorophyll derivatives in UV–visible spectrum and their signal intensity ratios. The optimal reaction conditions for the enzymatic reaction of four chlorophyll pigments were optimized, and kinetic models were fitted. The results showed that the optimal temperatures for the enzymatic reactions of chlorophyll a, chlorophyll b, pheophytin a, and pheophytin b were 30, 30, 60, and 60°C, respectively, and their optimal reaction time was 2, 3, 1, and 3 h, respectively. Kinetic models were fitted under optimal reaction conditions to study the Km and Vm values of the enzymatic reactions.Practical ApplicationDephytylated chlorophylls, such as chlorophyllide and pheophorbide, are frequently determined in food industry and are always required to be prepared in lab with acetone powder from plant tissue. Moreover, chlorophyll pigments are easy to undergo oxidations, which make the characterization of dephytylated chlorophyll pigments more complicated and difficult. In this paper, four types of phytylated chlorophylls were investigated respectively about the dephytinization process with the citrus acetone powder, and the reaction mixture was analyzed with UPLC–DAD–MS, which can provide an important reference for relevant chlorophyll determination studies and the development of chlorophyll identification protocols.
Effects of ethanol on mechanical allodynia and dynamic weight bearing in male and female mice with spared nerve injury
Authors: Nothem Mitchell A. , Wickman Jason R. , Giacometti Laura L. , Barker Jacqueline M. 
Published: December 2022

AbstractBackgroundMen and women with chronic pain report increased alcohol use and are more likely to be diagnosed with alcohol use disorder. The relationship between alcohol use and pain is bidirectional. Alcohol is used as an analgesic, but chronic alcohol intake increases pain. Sex differences in the relationship between chronic pain and alcohol are reported in the clinical and preclinical literature, but due to this bidirectional relationship, it is challenging to investigate the mechanisms that contribute to these differences. Thus, animal models of chronic pain are needed to characterize the efficacy of ethanol as an analgesic in males and females. The current experiments tested the hypothesis that ethanol differentially reduces pain behaviors in male and female mice in chronic neuropathic pain.MethodsThe spared nerve injury (SNI) model was used to investigate the analgesic effects of multiple doses of ethanol (0.5, 1, 2, g/kg i.p.) in male and female mice using von Frey and dynamic weight‐bearing (DWB) assays.ResultsIn both male and female mice, SNI led to robust allodynia and shifts in dynamic weight bearing. In male SNI mice, all three doses of ethanol fully reversed mechanical allodynia and shifts in DWB. In SNI females, only the highest dose (2.0 g/kg) was fully antiallodynic in the von Frey assay, while shifts in weight bearing were reversed at the 1.0 and 2.0 g/kg doses. The differences between male and females were not due to lower blood ethanol concentrations in female mice.ConclusionThese data indicate that while ethanol has antiallodynic and antinociceptive effects in male and female mice, the doses and time course of these effects are distinct. Studies investigating the relationship between pain and ethanol exposure in mice should consider sex as a key variable. These data also inform reported sex differences in rodent models of chronic pain and in chronic pain patients.
The effect of corruption on firm investment in the presence of missing data
Authors: Dastan Seyedmasood , Gibson John 
Published: December 2022

AbstractGreater availability of firm‐level surveys in developing countries has enabled researchers to consider the effects of corruption at the firm level. One often overlooked issue with these surveys is nonresponse by firms. We examine the impact of corruption on firm investment and demonstrate that failing to account for nonresponse leads to an overestimation of the impact of corruption.
Cognitive aids in the management of clinical emergencies: a systematic review
Authors: Greig P. R. , Zolger D. , Onwochei D. N. , Thurley N. , Higham H. , Desai N. 
Published: December 2022

SummaryClinical emergencies can be defined as unpredictable events that necessitate immediate intervention. Safety critical industries have acknowledged the difficulties of responding to such crises. Strategies to improve human performance and mitigate its limitations include the provision and use of cognitive aids, a family of tools that includes algorithms, checklists and decision aids. This systematic review evaluates the usefulness of cognitive aids in clinical emergencies. Following a systematic search of the electronic databases, we included 13 randomised controlled trials, reported in 16 publications. Each compared cognitive aids with usual care in the context of an anaesthetic, medical, surgical or trauma emergency involving adults. Most trials used only clinicians in the development and testing of the cognitive aids, and only some trials provided familiarisation with the cognitive aids before they were deployed. The primary outcome was the completeness of care delivered to the patient. Cognitive aids were associated with a reduction in the incidence of missed care steps from 43.3% to 11% (RR (95%CI) 0.29 (0.15–0.16); p < 0.001), and the quality of evidence was rated as moderate. The use of cognitive aids was related to decreases in the incidence of errors, increases in the rate of correctly performed steps and improvement in the clinical teamwork skills scores, non‐technical skills scores, subjective conflict resolution scores and the global assessment of team performance. Cognitive aids had an inconsistent influence on the time to first intervention and time to complete care of the patient's condition. It is possible that this was a reflection of how common or rare the crisis in question was as well as the experience and expertise of the clinicians and team. Sufficient thought should be applied to the development of the content and design of cognitive aids, with consideration of the pre‐existing guideline ecosystem. Cognitive aids should be tested before their deployment with adequate clinician and team training.
Experience with sotrovimab treatment of SARS‐CoV‐2‐infected patients in Denmark
Authors: Rasmussen Line Dahlerup , Lebech Anne‐Mette , Øvrehus Anne , Poulsen Birgitte Klindt , Christensen Hanne Rolighed , Nielsen Henrik , Johansen Isik Somuncu , Omland Lars Haukali , Wiese Lothar , Helleberg Marie , Storgaard Merete , Dalager‐Pedersen Michael , Rasmussen Thomas A. , Benfield Thomas , Petersen Tonny Studsgaard , Andersen Åse Bengård , Gram Mie Agermose , Stegger Marc , Edslev Sofie Marie , Obel Niels 
Published: December 2022

AimsTo evaluate the experience with use of sotrovimab following severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection in high‐risk groups.MethodsIn a nationwide, population‐based cohort study, we identified all individuals treated with sotrovimab (N = 2933) and stratified them by 4 high‐risk groups: (A) malignant haematological disease, (B) solid organ transplantation, (C) anti‐CD20 therapy ≤1 year and (D) other risks. Cox regression analysis was used to calculate hazard ratios for hospitalization, death and associated prognostic factors.ResultsOf 2933 sotrovimab‐treated individuals, 83% belonged to high‐risk groups (37.6% haematological malignancy, 27.4% solid organ transplantation and 17.5% treatment with anti‐CD20 ≤1 year). Only 17.8% had other risks (11.8% were pregnant, 10.7% primary immunodeficiency, 21.2% other malignancy, 4.3% received anti‐CD20 >1 year and 52.0% other/unknown causes). Within 90 days of infusion, 30.2% were hospitalized and 5.3% died. The main prognostic factors were the predefined high‐risk groups, mainly malignant haematological disease and age ≥65 years. Number of COVID‐19 vaccines (≥3) was associated with a decreased risk of hospitalization. The Delta but not the Omicron BA.2 variant was associated with a higher risk of death compared to the BA.1 variant.ConclusionMore than 90% of the patients treated with sotrovimab belonged to the very high‐risk groups as described in the Danish guidelines. Sotrovimab‐treated individuals remained at a high risk of hospitalization and death which was strongly associated with the underlying immunocompromised state and age. Having received >3 COVID‐19 vaccines was association with decreased risk of death and hospitalization.