bluuebunny/crossref_metadata_2025_split huggingface dataset:
The long term study of the difference in efficacy and effect rate of various concentrations of retinol (1500–6600 IU) in middle age women
Authors: Jang Sue Im , Jung Yu-Chul , Suk Jangmi , Lee Sieun , Han Jaeil , Suh Byung-Fhy , Kim Eunjoo 
Published: October 2022

Abstract
Purpose

Retinol is widely used for topical application for antiaging. However, the efficacy and effect rate of different concentrations of retinol have been rarely analyzed. Therefore, in this study, the efficacy and rate of effect of retinol concentrations from 1500 IU to 6600 IU, on various skin parameters, have been compared.

Patients and methods

Seventy-two Korean women aged 40 to 59 years participated in this study. Retinol was used by them for 24 weeks; the effects were measured at 0, 2, 4, 8, 12, and 24 weeks. The measurement parameters for aging were crow’s feet, forehead wrinkles, nasolabial fold, dermal density, and elasticity and that for skin color were skin brightness, yellowness, redness, and standard deviation of skin brightness. The texture of the skin was measured by measuring the skin roughness and pores, and the skin barrier function was evaluated through hydration, sebum, and desquamation.

Results

Low concentration retinol (1500–2500 IU) had a significantly higher effect in skin color, brightness, and elasticity and faster improvement rate in skin brightness and elasticity compared to that for high concentration (3300–6600 IU). High concentration of retinol had a significantly higher effect in wrinkles, dermal density and pores and faster improvement rate for wrinkles, skin texture, pores, and desquamation compared to that for low concentration.

Conclusion

This study evaluated the changes caused by different concentration of retinol over a long period of time. The results of this study have great implications as the optimal concentration of retinol can be prescribed for an accurate period for the desired results without side effects.
Eco-friendly Green Composites Reinforced with Recycled Polyethylene for Engineering Applications
Authors: Azeko Salifu Tahiru , Mensah Jacob Kofi , Arthur Emmanuel Kwesi , Abiwu Napoleon , Flomo Moses Kingsford , Boadu Joseph Asiamah , Yamba Philip , Larson Enoch Asuako , Akayeti Anthony , Satankar Raf Kumar , Annan Ebenezer 
Published: October 2022

Abstract
Polyethylene (PE) and cement are serious industrial wastes that promote environmental pollution, with these pollutants having tremendous effects on the lives of humanity and other living creatures, including animals. Therefore, this research presents the results of experimental and theoretical modeling of green composites (without the inclusion of cement) reinforced with recycled polyethylene waste for applications in the Mechanical and Civil Engineering industry. The composites are produced using different weight percentages of laterite and molten PE mixed homogeneously to produce unique green composites with excellent mechanical properties. The green composite with 40 wt.% laterite and 60 wt.% PE exhibited the highest compressive strength, flexural strength and fracture toughness of 25 MPa, 7.3 MPa and 0.6 MPa√m, respectively. Additionally, the green composite recorded maximum yield stress of ∼2 MP. The maximum yield stress of the green composites falls under the minimum range of yield stress for traditional concrete structures. The SEM images reveal evidence of bonding and ligament bridging in the green composites reinforced with 40 wt.% laterite and 60 wt.% PE. The probability distribution plots show that the polyethylene in the green composites follows the Weibull distribution with low Anderson Darling Statics and p-values greater than the significance level of 5%.
Mobility Management in 5G Network on the Efficiency Hierarchical State of Slicing
Authors: CHAFFAI AMAL 
Published: October 2022

Abstract
Performing quality of service thanks to mobility management in network slicing such as seamless handover brings new challenges. Wherefore, to build and manage a 5G network, that cope and exceeds the emerging requirements of a full-scale range of users. Massive wireless data traffic from different application scenarios. Need, to transform it into a set of logical networks of a shared infrastructure. To configure and connect end-to-end anytime, anywhere, regardless of the access channels characteristics. To attend a defined business purpose and comprise all the required network resources. In this study, we discuss the background and related work in network slicing. Then, we present a framework for 5G network slicing mobility management, a versatile model based on a two-tier pattern. Handled by the massive wireless data traffic from different application scenarios. Keeping into consideration that depends on the design parameter PB blocking probability for homogenous models, and the generic value radii R = (r max) as the minimum communication range required in the heterogeneous models. To achieve a configurable balance between power saving and latency in 5G mobility management.
One-Pot Cascade Construction of Nonsubstituted Quinoline-Bridged Covalent Organic Frameworks
Authors: Xiang Yonggang , Pang Huaji , Huang Dekang , Zhu Yanqiu , Zhao Xiaodong 
Published: October 2022

AbstractIrreversible locking of imine linkage into stable linkages represents a promising strategy to improve the robustness and functionality of covalent organic frameworks (COFs). We report, for the first time, a multi-component one-pot reaction (OPR) for imine annulation to construct highly stable nonsubstituted quinoline-bridged COFs (NQ-COFs), and equilibrium regulation of reversible/irreversible cascade reactions by addition of desiccant MgSO4is crucial to achieve high conversion efficiency and crystallinity. The higher long-range order and surface area of NQ-COFs synthesized by OPR than the reported two-step post-synthetic modification (PSM) facilitate charge carriers’ transfer and photogenerated ability of superoxide radical (O2•−), which makes these NQ-COFs be more efficient photocatalysts for O2•−mediated synthesis of 2-benzimidazole derivatives. The general applicability of this synthetic strategy is demonstrated by fabricating 12 other crystalline NQ-COFs with a diversity of topologies and functional groups.
Risk of respiratory diseases with use of psychotropic drugs: Results of a community-based cross-sectional study from South India
Authors: Eby Abhirami , Jacob Elsa , P Samuel Gideon George 
Published: October 2022

AbstractBackground A cross-sectional study was conducted using a validated questionnaire among patients on psychotropic medications or their caregivers at a community pharmacy. The study evaluated the effect of various psychotropic drugs on pulmonary function to identify the psychotropic drug class most commonly associated with risk of respiratory disorders. Since psychotropic medications have safety concerns for usage in the general population, their use in people with coronavirus disease (COVID-19) is considered challenging. The study may also serve to draw evidence based practical recommendations for the treatment of people with COVID-19. Results Cronbach’s alpha and Intra class correlation coefficient values were found to be 0.92 and 0.85 respectively. In a sample of 198 patients, benzodiazepines were the commonly used medication among the population (43.9%) followed by selective serotonin re-uptake inhibitors (21.2%), anti-psychotics (15.1%), mood stabilizers (7.6%) and others (12.2%). Statistically significant association was observed between history of benzodiazepine usage, second generation antipsychotics and respiratory disorders (OR 1.56 [1.1–2.3, P < 0.1]). However the use of first generation antipsychotics were found to be less associated with respiratory infections. Conclusion History of benzodiazepine and second generation antipsychotic usage were found to be associated significantly with respiratory disorders including pneumonia and acute respiratory distress. Hence patients on psychotropics should be monitored for respiratory symptoms and choice of anti-psychotic medications should be made on existing clinical evidence. Psychotropic drugs which were found to be safer through the study conducted can be chosen to help improve the quality of psychiatric care in people with COVID-19, also promoting an optimal management of the psychiatric condition without worsening the medical condition due to COVID-19.
Unstable aluminum segregation phenomenon in blind keyhole laser welds of Al-Si coated hot stamping steel
Authors: Lin Wenhu , Zhang Zhenbo 
Published: October 2022

Abstract
Al-Si coated hot stamping steel is widely used in weight reduction of vehicles, due to its ultra-high strength and good formability. Aluminum coating promotes the formation of aluminum-rich brittle phase segregated in laser welds, such as delta ferrite, or Fe-Al intermetallics, which severely deteriorates the mechanical properties of tailor-welded blanks. A thorough understanding of segregation mechanism is beneficial for the chemical heterogeneity in macro scale. In this work, a three-dimension model is proposed to describe keyhole mode laser welding of coated Al-Si coating. The statistical analysis indicates aluminum element is uniformly distributed at top regions with a average concentration of 20 vol.% and fluid flow time of 25-38 ms whereas several random segregation regions appear at the bottom, and the keyhole opening at the bottom is unstable. The initial element distribution determines the segregation characteristics that coating element mainly comes from the upper surface, circular fluid flowing around the keyhole, but few from the front wall of the keyhole at the partial penetration stage.
Chest CT diagnostic potential as a tool for early detection of suspected COVID-19 cases in pandemic peaks
Authors: Chervenkov Lyubomir ,   Ralitsa Raycheva3, Rangelova Vanya , Doykova Katya 
Published: October 2022

Abstract

Introduction: The emergence of severe acute respiratory syndrome coronavirus disease (COVID-19) in China at the end of 2019 has caused a large global outbreak and is a major public health issue. Our aim is to investigate the diagnostic potential of chest CT in screening patients suspected of COVID-19 in high-prevalence settings.
Materials and methods: This is a real-life, prospective, observational study involving 260 patients. All patients performed chest CT at the emergency department (ED) of Kaspela University Hospital, Plovdiv, Bulgaria and RT-PCR testing for suspected COVID-19 from March 27 to December 31, 2020. COVID-19 likelihood was assessed by assigning each CT scan to a particular category of the COVID-19 Reporting and Data System (CO-RADS). IBM SPSS software v.26 was used for processing the data.
Results: The male-to-female distribution was 1.4:1 – 150 (57.7%) males vs 110 (42.3%) females (p=0.014). The median age was 55 yrs. (46; 65 yrs.). Discharged patients were 247 (95.0%), the rest died in the COVID-19 intensive care unit (ICU). Males were 4.13 times more likely to be diagnosed with CO-RADS≥3 score than females. Increasing age was associated with an increased likelihood of being classified with higher CO-RADS scores. The ROC curves analysis demonstrated that CO-RADS≥3 was the optimal cutoff for discriminating between a positive and negative PCR (Youden’s index J=0.67), with an AUC of 0.825 (95% CI: 0.72-0.93), sensitivity of 91.9% (95% CI: 87.7%-95.1%), specificity of 75.0% (95% CI: 53.3%-90.2%) and accuracy of 76.4% (95% CI: 70.7% to 81.4%).
Conclusion: Based on our study the CT examination provides a quick and accurate diagnosis of patients with suspected COVID-19 infection, as the PCR testing is time-consuming and the delay of obtaining results could be substantial when the incidence curve starts to grow rapidly.
Efficacy of a Single Session Mindfulness Based Intervention
Authors: Rubin Mikael , Fischer Caitlin , Telch Michael J 
Published: October 2022

AbstractObjectives Loneliness, perceived stress, depression, and anxiety have increased during the COVID-19 pandemic. Many of existing mindfulness and compassion-based intervention are effective, but are time-intensive, decreasing overall accessibility and scalability. Single-session interventions (SSIs) serve as a promising alternative. The current pre-registered clinical trial evaluated a newly developed, manualized, mindfulness-based SSI. Methods 91 adults were randomly assigned to one of three conditions: (1) one-hour mindfulness only telehealth intervention; (b) one-hour mindfulness and compassion telehealth intervention; or (c) one-week waitlist control (before randomization to an active intervention). Intervention sessions were conducted by graduate students in clinical psychology. The primary outcome was self-reported loneliness; secondary outcomes were self-reported perceived stress, depression, and anxiety. Bayesian multi-level models were conducted to test differences between active interventions and waitlist at the 1-week follow-up and between active interventions at the 2-week follow-up. Results We found overall reductions in self-reported loneliness at the 2-week follow-upb= -2.36, 95% Highest Density Interval (HDI) [-3.36, -1.36], however there was no difference between the active interventions and waitlist at the 1-week follow-up. Compared to the waitlist-control, the inclusion of a compassion component led to meaningful reductions in perceived stressb= -3.75, 95% HDI [-6.95, -0.59], anxietyb= -3.79, 95% HDI [-6.99, -0.53], and depressionb= -3.01, 95% HDI [-5.22, -0.78] at the 1-week follow-up. Conclusions Results suggest that a single-session mindfulness and compassion intervention may lead to meaningful reductions in perceived stress, symptoms of anxiety, and symptoms of depression, but not loneliness. Implications of these findings are discussed.
The Effect of Room Temperature on the Spread of the Covid-19 Virus by Creating a Special Isolation Room with a Hot Temperature for Those Indicated as Medical Service Facilities
Authors: Anwar Hendi 
Published: October 2022

During the Covid-19 pandemic, there were many alternatives to anticipate or anticipate through certain tools and media with less effectiveness and endanger the users, for example, a device that can be called a disinfecting chamber or "disinfection chamber". Quoted from CNN Indonesia, sourced from the WHO Indonesia Twitter account that not to spray alcohol or chlorine directly on the body, spraying such chemicals can be dangerous if exposed to clothing or mucous membranes (example: eyes, mouth) . Alcohol and chlorine can be used on the surface of the body with instructions or user guides. With an official statement from the world health organization directly that it can endanger health, there must be a breakthrough in new media that is safer for users . According to scientists from Aix-Marseille University in France, if the corona virus is exposed to high temperatures it can reduce the life span of the virus itself or can kill the virus itself at 92 degrees Celsius within 15 minutes (quoted from DetikHealt.com) . Giving heat to the room itself using heating by providing steam as in the sauna room and the interior elements are also applied special heat-resistant materials without compromising the safety and health of the users of the room . Then this room will be in health centers that move to handle patients who are examined and also useful for medical practitioners who treat patients . With a room that has a high temperature is expected to minimize the spread of the virus on an ongoing basis and neutralized our bodies outside of the virus in a safe way , because reported by various news , the specialists in internal medicine provide a statement that the virus that is outside the host or can be called a part of our body can last within 3 hours without handling such as washing hands using a handsanitizer or other treatments . The output of the research itself is a room with a hot temperature with wood material and the shape of the room adapts to the needs and existing literature, Then the benefits of this research can be realized a tool to inhibit the spread of the Covid-19 virus and can be used as much as possible for health workers and people who need it.
Key Word : Covid-19, Disinfection Chamber , Isolation Room
Does the urban poor want water service improvement? Residents’ preferences for future water service supply in the Central Rift Valley of Ethiopia
Authors: Entele Birku Reta 
Published: October 2022

Abstract
Access to clean and adequate drinking water supply has a significant contribution to public health and the economies of developing nations. However, leaders in developing countries continue to experience challenges in their attempt to provide citizens access to safe drinking water. This study examines residents’ preferences for improved water service supply attributes in the Central Rift Valley of Ethiopia. Using a conjoint experiment survey from 450 residents, the study estimates part-worth valuation for each attribute and shows that preference for future water service is heterogeneous. Finally, the researchers confirmed that the resident is willing to pay up to 75% surcharges on their current bill for improved drinking water supply.
Available online sensors can be used to create fingerprints for MABRs that characterize biofilm limiting conditions and serve as soft sensors
Authors: Yang Cheng , Houweling Dwight , He Huanqi , Daigger Glen T. 
Published: October 2022

Abstract
Membrane aerated biofilm reactors (MABRs) are a promising biological wastewater treatment technology, whose industrial applications have dramatically accelerated in the last five years. Increased popularity and fast industrial adaptation are coupled with increased needs to monitor, optimize, and control MABRs with available online sensors. Observations of commercial scale MABR installations have shown a distinctive and repetitive pattern relating oxygen purity in MABR exhaust gas to reactor ammonia concentrations. This provides an obvious opportunity for process monitoring and control which this paper investigates with the help of modeling. The relationship plots between the bulk ammonia concentration and the oxygen purity are defined as MABR fingerprint plots, which are described in the form of steady-state curves and dynamic trajectories. This study systematically investigated, analyzed, and explained the behaviors and connections of steady-state curves and dynamic trajectories with a MABR model in SUMO®, and proposed a hypothesis about utilizing the MABR fingerprint plots to characterize MABR system performance, identify the limiting factor of biofilms, and possibly develop a soft senor for MABR biofilm thickness monitoring and control.
Oleamide: An Endogenous Sleep-inducing Lipid and Prototypical Member of a New Class of Biological Signaling Molecules
Authors: Boger Dale L. , Henriksen Steven J. , Cravatt Benjamin F. 
Published: October 2022

Abstract:
Oleamide is an endogenous fatty acid primary amide that accumulates in the cerebrospinal fluid under conditions of sleep deprivation and induces physiological sleep in animals. A review covering its discovery, its implications, and the emerging biology surrounding its discovery is presented. Consistent with its role as a prototypical member of a new class of biological signaling molecules, enzymatic regulation of endogenous concentrations of oleamide have been characterized or proposed. Fatty acid amide hydrolase (FAAH) is an integral membrane protein that degrades oleamide and potent inhibitors with physiological sleep-inducing properties have been disclosed. The characterization, cloning, and neuronal distribution of FAAH have been detailed and the enzyme was found to possess the ability to hydrolyze a range of fatty acid amides including anandamide which serves as the endogenous ligand for the cannabinoid receptor. An additional endogenous substance with REM sleep-inducing properties, 2-octyl y-bromoacetoacetate, was characterized as a potent FAAH inhibitor. Oleamide has been shown to modulate serotonergic neurotransmission and inhibit intercellular gap junction communication and detailed studies of its well defined and selective structural features required for activity have been disclosed.
Discovery of Ascomycin Analogs with Potent Topical but Weak Systemic Activity for Treatment of Inflammatory Skin Diseases
Authors: Mollison Karl W. , Fey Thomas A. , Gauvin Donna M. , Sheets Michael P. , Smith Morey L. , Pong Melissa , Krause Ruth , Miller Loan , Or Yat Sun , Kawai Megumi , Wagner Rolf , Wiedeman Paul E. , Clark Richard F. , Gunawardana Indrani W. K. , Rhoades Teresa A. , Henry Cynthia L. , Tu Noah P. , BaMaung Nwe Y. , Kopecka Hana , Liu Luping , Xie Qinghua , Lane Benjamin C. , Trevillyan James M. , Marsh Kennan , Carter George W. , Chen Yung-Wu , Hsieh Gin C. , Luly Jay R. 
Published: October 2022

Abstract:
Drug therapy for the major inflammatory skin diseases, which include atopic dermatitis, psoriasis and allergic contact dermatitis, is often inadequate due to poor efficacy, toxicity, or both. Much research has focused on the macrolactam T cell inhibitors as a promising new class of agents for immunotherapy, and medicinal chemistry efforts to design novel ascomycin analogs have produced clinically promising agents. A synthetic program to modify the ascomycin nucleus to alter its physicochemical properties and promote systemic clearance is described. A biologic screening strategy to identify analogs with reduced systemic activity and rapid phannacokinetic elimination led to identification of the clinical candidate, ABT-281. A swine contact hypersensitivity model was used as a stringent indicator of skin penetration as human doses of topical corticosteroids produced inhibition only in the 50% range and ED50 values were 100-fold less potent than in rat. Also, cyclosporine was confirmed to be topically inactive in swine, as seen in human. ABT-281 had topical potency equal to tacrolimus (FKS06) despit_e a severalfold lower potency for inhibiting swine T cells in vitro, consistent-with superior skin penetration. ABT-281 was found to have a shorter duration of action after i.v. dosing in monkeys using an ex vivo whole blood IL-2 production assay. Systemic potency was reduced by 30- fold or more in rat popliteal lymph node hyperplasia and contact hypersensitivity assays. Following i.v. or i.p. administration in the swine contact hypersensitivity model, ABT-281 was 19- and 61-fold less potent, respectively, than FK506. Pharmacokinetic studies showed that ABT-281 had a shorter half life and higher rate of clearance than FKS06 in all three species. The potent topical activity and reduced sytemic exposure of ABT- 281 may thus provide both efficacy and a greater margin of safety for topical therapy of skin diseases.