bluuebunny/crossref_metadata_2025_split huggingface dataset:
KEANEKARAGAMAN JAMUR MAKROSKOPIS DI KAWASAN AIR TERJUN CURUG EMBUN KOTA LUBUKLINGGAU
Authors: Afrita Erni , Jayati Ria Dwi , Riastuti Reny Dwi 
Published: January 2022

This study aims to determine the types, diversity index, species evenness index, dominance index, and relative density of macroscopic fungi in the Waterfall area of ​​Curug Embun, Marga Bakti Village, North Lubuklinggau District I. This research is quantitative descriptive. Data collection techniques in this study using the roaming method with sampling using purposive sampling technique. The results of the analysis of the macroscopic fungal diversity index in the Curug Embun Waterfall area were 1.3530, the species evenness index was 0.4516, the dominance index was 0.4776 and the highest relative density was 68.027%. There are 3 edible species and 17 non-edible mushrooms. 17 species of macroscopic mushrooms in the Waterfall area of ​​Curug Embun were found. The diversity index, dominance, and Simpson index are in the medium category. Schizophyllum commune is the most commonly found species.
Quality life evaluation after mastectomy or Quart
Authors: Cordova Adriana , D’Antonio Giovanni Maria 
Published: January 2022

Breast cancer is a worldwide diffused disease and represents the most common tumor among women. Due to great improvements in prevention protocols and imaging, most patients are diagnosticated with non-advanced disease and can either be treated with mastectomy or quadrantectomy/lumpectomy plus adjuvant radiotherapy (QUART). Both procedures yield similar outcomes in terms of disease free survival, hence greater attention is been drawn towards improving patients’ quality of life following treatment. The purpose of the present retrospective, monocentric study is to assess whether there is a significant difference between the radical (mastectomy with immediate reconstruction) and conservative (QUART) ways of treating breast cancer in terms of patient’s perception of disease and quality of life using the BREAST-Q questionnaire.
Predictors of Central Compartment Involvement in Patientswith Positive Lateral Cervical Lymph Nodes Accordingto Clinical and/or Ultrasound Evaluation
Authors: Rollo Enza Maria 
Published: January 2022

Lymph node neck metastases are frequent in papillary thyroid carcinoma (PTC). Current guidelines state, on a weak level of evidence, that level VI dissection is mandatory in the presence of latero-cervical metastases. The aim of our study is to evaluate predictive factors for the absence of level VI involvement despite the presence of metastases to the lateral cervical stations in PTC. Eighty- eight patients operated for PTC with level II–V metastases were retrospectively enrolled in the study. Demographics, thyroidfunction, autoimmunity, nodule size and site, cancer variant, multifocality, Bethesda and EU-TIRADS, number of central and lateral lymph nodes removed, number of positive lymph nodes and outcomewere recorded. At univariate analysis,PTC location and number of positive lateral lymph nodes were risk criteria for failure to cure. ROC curves demonstrated the association of the number of positive lateral lymph nodes and failure to cure. On multivariate analysis, the protective factors were PTC located in lobe center and number of positive lateral lymph nodes < 4. Kaplan–Meier curves confirmed the absence of central lymph nodes as a positive prognostic factor. In the selected cases, Central Neck Dissection (CND) could be avoided even in the presence of positive Lateralcervical Lymph Nodes (LLN ).
Phonological Processes in Ekegusii Borrowing: A Constraint-based Approach
Authors: Mose Edinah 
Published: January 2022

Phonological processes are at the heart of linguistic borrowing as it has varied phonological systems. It could be seen that the loan words entering the loan language from the source language can hardly be separated from the phonological process because they must be modified to suit the phonology of the loan language. This article analysed the phonological processes realized in Ekegusii borrowing from English using Optimality Theory’s constraint approach. Since this was a phonological study, descriptive linguistic fieldwork was used. The data used in this article was extracted from Mose’s doctoral study, whereby purposive sampling was used to obtain two hundred borrowed segments from the Ekegusii dictionary, then supplemented by introspection. Further, three adult native proficient Ekegusii speakers who were neither too young nor too old and had all their teeth were purposively sampled. The two hundred tokens were then subjected to the sampled speakers through interviews to realize the sound patterns in the Ekegusii borrowing process overtly. The findings revealed that Ekegusii phonological constraints defined the well-formedness of the loanwords by repairing the illicit structures. To fix, various phonological processes were realized. They included: epenthesis, deletion, devoicing/strengthening, voicing/ weakening, re-syllabification, substitution, monophthongization, and lenition. The article concludes that borrowing across languages (related or unrelated) reports similar if not the same phonological processes only that the processes attested in one language are a subset of the universally exhibited phonological processes.
Estudio observacional, multicéntrico de la incidencia y patrones de tratamiento de anemia aplástica adquirida en cuatro hospitales de referencia nacional en Perú.
Authors: La Torre-Matuk Alejandra , Vidal Semanche Gabriela-Urpi , Tokumura-Tokumura Carmen Carolina , Pastor García-Castro Edgard , Méndez-Silva Francisco José , Medina-Sánchez Cecilia Alexandra 
Published: January 2022

Objetivos: Describir la frecuencia de Anemia Aplásica (AA) adquirida en cuatro hospitales principales de referencia, así como los patrones de tratamiento de esta enfermedad en el Perú. Métodos: Se realizó un estudio observacional, multicéntrico, retrospective para 2016 y prospectivo durante 2017 en los hospitales Nacional Arzobispo Loayza, Nacional Cayetano Heredia, Edgardo Rebagliati Martins y Carlos Alberto Seguín Escobedo. Resultados: Se reclutaron 48 pacientes, 21(43,8%) presentaron anemia severa, 26(54,2%) no estuvieron expuestos a ningún tóxico, pero 6 (12,5%) estuvieron expuestos a organofosforados. Veinticinco de cuarenta y ocho (52,1%) iniciaron el tratamiento con el esquema metilprednisolona + ciclosporina + globulina anti-timocítica (de conejo o de caballo). La mediana del tiempo de diagnóstico hasta el inicio de tratamiento fue 28,5 días. Solo a 3 (6,25%) pacientes se realizó trasplante de médula como tratamiento inicial. Once (22,91%) fallecieron durante el estudio. La prevalencia e incidencia estimadas son de 9 y 5 por millón, respectivamente. Conclusiones: El tiempo desde el diagnóstico hasta el inicio del tratamiento fue largo. Los eventos adversos serios más comunes fueron los infecciosos, tal como ha sido reportado en estudios similares. La mortalidad a los 12 meses de seguimiento fue alta en comparación a la de otros estudios. Casi la mitad de los pacientes no recibió terapia de primera línea.
A Sustainable Approach for Synthesizing (R)-4-Aminopentanoic Acid From Levulinic Acid Catalyzed by Structure-Guided Tailored Glutamate Dehydrogenase
Authors: Zhou Feng , Xu Yan , Mu Xiaoqing , Nie Yao 
Published: January 2022

In this study, a novel enzymatic approach to transform levulinic acid (LA), which can be obtained from biomass, into value-added (R)-4-aminopentanoic acid using an engineered glutamate dehydrogenase from Escherichia coli (EcGDH) was developed. Through crystal structure comparison, two residues (K116 and N348), especially residue 116, were identified to affect the substrate specificity of EcGDH. After targeted saturation mutagenesis, the mutant EcGDHK116C, which was active toward LA, was identified. Screening of the two-site combinatorial saturation mutagenesis library with EcGDHK116C as positive control, the kcat/Km of the obtained EcGDHK116Q/N348M for LA and NADPH were 42.0- and 7.9-fold higher, respectively, than that of EcGDHK116C. A molecular docking investigation was conducted to explain the catalytic activity of the mutants and stereoconfiguration of the product. Coupled with formate dehydrogenase, EcGDHK116Q/N348M was found to be able to convert 0.4 M LA by more than 97% in 11 h, generating (R)-4-aminopentanoic acid with &gt;99% enantiomeric excess (ee). This dual-enzyme system used sustainable raw materials to synthesize (R)-4-aminopentanoic acid with high atom utilization as it utilizes cheap ammonia as the amino donor, and the inorganic carbonate is the sole by-product.
Electroclinical and Multimodality Neuroimaging Characteristics and Predictors of Post-Surgical Outcome in Focal Cortical Dysplasia Type IIIa
Authors: Zhang Lingling , Zhou Hailing , Zhang Wei , Ling Xueying , Zeng Chunyuan , Tang Yongjin , Gan Jiefeng , Tan Qinghua , Hu Xiangshu , Li Hainan , Cheng Baijie , Xu Hao , Guo Qiang 
Published: January 2022

Focal cortical dysplasia (FCD) type IIIa is an easily ignored cause of intractable temporal lobe epilepsy. This study aimed to analyze the clinical, electrophysiological, and imaging characteristics in FCD type IIIa and to search for predictors associated with postoperative outcome in order to identify potential candidates for epilepsy surgery. We performed a retrospective review including sixty-six patients with FCD type IIIa who underwent resection for drug-resistant epilepsy. We evaluated the clinical, electrophysiological, and neuroimaging features for potential association with seizure outcome. Univariate and multivariate analyses were conducted to explore their predictive role on the seizure outcome. We demonstrated that thirty-nine (59.1%) patients had seizure freedom outcomes (Engel class Ia) with a median postsurgical follow-up lasting 29.5 months. By univariate analysis, duration of epilepsy (less than 12 years) (p = 0.044), absence of contralateral insular lobe hypometabolism on PET/MRI (pLog-rank = 0.025), and complete resection of epileptogenic area (pLog-rank = 0.004) were associated with seizure outcome. The incomplete resection of the epileptogenic area (hazard ratio = 2.977, 95% CI 1.218–7.277, p = 0.017) was the only independent predictor for seizure recurrence after surgery by multivariate analysis. The results of past history, semiology, electrophysiological, and MRI were not associated with seizure outcomes. Carefully included patients with FCD type IIIa through a comprehensive evaluation of their clinical, electrophysiological, and neuroimaging characteristics can be good candidates for resection. Several preoperative factors appear to be predictive of the postoperative outcome and may help in optimizing the selection of ideal candidates to benefit from epilepsy surgery.
Ticagrelor vs. Clopidogrel in Acute Coronary Syndrome Patients With Chronic Kidney Disease After New-Generation Drug-Eluting Stent Implantation
Authors: Roh Ji Woong , Lee Seung-Jun , Kim Byeong-Keuk , Hong Sung-Jin , Kim Hee-Yeol , Ahn Chul-Min , Cho Deok-Kyu , Kim Jung-Sun , Ko Young-Guk , Choi Donghoon , Hong Myeong-Ki , Jang Yangsoo 
Published: January 2022

Background: The impact of ticagrelor-based dual antiplatelet therapy (DAPT) on acute coronary syndrome (ACS) in patients with chronic kidney disease (CKD) remains unclear.Methods: Data on a total of 1,067 ACS patients with CKD including end-stage renal disease (ESRD) who underwent new-generation drug-eluting stent implantation were extracted from a multicenter registry. This study aimed to compare outcomes of patients treated with ticagrelor- (n = 449) and those treated with clopidogrel-based (n = 618) DAPT. Outcomes of interest included major adverse cardiac and cerebrovascular events (MACCEs) and bleeding (Bleeding Academic Research Consortium grade 3 or 5) at 12 months. Propensity-score matching (346 pairs) analysis was performed.Results: The patients with ESRD showed the highest MACCE and bleeding rates (P &lt; 0.001). There was no difference in the rate of MACCEs between the treatment groups (7.8% vs. 8.4%; hazard ratio [HR] = 0.95, 95% confidence interval [CI] = 0.56–1.61, P = 0.855); however, a trend toward an increased bleeding rate was observed in the ticagrelor-based DAPT group (6.8% vs. 3.8%, HR = 1.84, 95% CI = 0.93–3.63, P = 0.079). Among patients with CKD stage III/IV but without ESRD (277 pairs), the ticagrelor-based DAPT group showed a reduced MACCE rate (3.6% vs. 8.7%, HR = 0.41, 95% CI = 0.19–0.86, P = 0.018) and a similar bleeding rate (5.1% vs. 3.2%, HR = 1.61, 95% CI = 0.70–3.71, P = 0.267), compared with those of the clopidogrel-based DAPT group.Conclusion: The effects of ticagrelor-based DAPT on ischemic and bleeding outcomes of ACS patients with CKD varied according to CKD stage; in ACS patients with CKD without ESRD, ticagrelor-based DAPT reduced MACCE risk without increasing bleeding risks, relative to those observed with clopidogrel-based DAPT.
Higher Plasma Pentraxin-3 Level Predicts Adverse Clinical Outcomes in Patients With Coronary Artery Disease: A Meta-Analysis of Cohort Studies
Authors: Ding Kejun , Shi Zhewei , Qian Caizhen , Yang Xuan 
Published: January 2022

Background: Association between plasma pentraxin-3 (PTX-3) and clinical outcomes in patients with coronary artery disease (CAD) remains not fully determined. An updated meta-analysis of cohort studies was performed to systematically evaluate the association.Methods: Cohort studies evaluating the association between plasma PTX-3 and adverse outcomes [mortality and major adverse cardiovascular events (MACEs)] in adults with CAD were identified by systematic search of PubMed, Embase, and Web of Science databases. Only studies with multivariate analysis were included. A random-effects model incorporating the potential intrastudy heterogeneity was used for the meta-analysis.Results: A total of 16 studies including 11,007 patients were included. Pooled results showed that patients with highest level of PTX-3 were independently associated with higher risk of mortality [adjusted risk ratio (RR): 2.09, 95% CI: 1.60 to 2.74, p &lt; 0.001; I2 = 50%] and MACEs (adjusted RR: 1.80, 95% CI: 1.43 to 2.28, p &lt; 0.001; I2 = 49%). Subgroup analyses showed that the associations between PTX-3 and poor prognosis in CAD were consistent in patients with ST-segment elevation myocardial infraction, non-ST-segment elevation acute coronary syndrome, and stable CAD (p &lt; 0.05 for each subgroup). Besides, the association between PTX-3 and increased incidence of mortality and MACEs were consistent in short-term (within 1 year) and long-term (over 1 year) studies and in studies with or without adjustment of C-reactive protein (CRP) (p &lt; 0.05 for each subgroup).Conclusion: Higher plasma PTX-3 is associated with poor prognosis in patients with CAD, which may be independent of the CAD subtype, follow-up durations, and adjustment of CRP.
Trends in the Degree of Control and Treatment of Cardiovascular Risk Factors in People With Type 2 Diabetes in a Primary Care Setting in Catalonia During 2007–2018
Authors: Mata-Cases Manel , Vlacho Bogdan , Real Jordi , Puig-Treserra Ramon , Bundó Magdalena , Franch-Nadal Josep , Mauricio Didac 
Published: January 2022

ObjectiveTo assess the trends in cardiovascular risk factor control and drug therapy from 2007 to 2018 in subjects with type 2 diabetes mellitus (T2DM).Materials and MethodsCross-sectional analysis using yearly clinical data and treatment obtained from the SIDIAP database. Patients aged ≥18 years with a diagnosis of T2DM seen in primary care in Catalonia, Spain. ResultsThe number of T2DM patients increased from 299,855 in 2007 to 394,266 in 2018. We also found an increasing prevalence of cardiovascular disease, heart failure, and chronic kidney disease (from 18.4 to 24.4%, from 4.5 to 7.3%, and from 20.2 to 31.3%, respectively). The achievement of glycemic targets (HbA1c&lt;7%) scarcely changed (54.9% to 55.9%). Major improvements were seen in blood pressure (≤140/90 mmHg: from 55% to 71.8%), and in lipid control (low-density lipoprotein cholesterol &lt;100 mg/dl: 33.4% to 48.4%), especially in people with established cardiovascular disease (48.8 to 69.7%). Simultaneous achievement of all three targets improved from 12.5% to 20.1% in the overall population and from 24.5% to 32.2% in those with cardiovascular disease but plateaued after 2013. There was an increase in the percentage of patients treated with any antidiabetic drug (70.1% to 81.0%), especially metformin (47.7% to 67.7%), and DPP4i (0 to 22.6%). The use of SGLT-2 and GLP-1ra increased over the years, but remained very low in 2018 (5.5% and 2.1% of subjects, respectively). There were also relevant increases in the use of statins (38.0% to 49.2%), renin-angiotensin system (RAS) drugs (52.5% to 57.2%), and beta-blockers (14.3% to 22.7%).ConclusionsDuring the 2007-2018 period, relevant improvements in blood pressure and lipid control occurred, especially in people with cardiovascular disease. Despite the increase in the use of antidiabetic and cardiovascular drugs, the proportion of patients in which the three objectives were simultaneously achieved is still insufficient and plateaued after 2013. The use of antidiabetic drugs with demonstrated cardio renal benefits (SGLT-2 and GLP-1ra) increased over the years, but their use remained quite low.
Identifying Potential miRNA Biomarkers for Gastric Cancer Diagnosis Using Machine Learning Variable Selection Approach
Authors: Gilani Neda , Arabi Belaghi Reza , Aftabi Younes , Faramarzi Elnaz , Edgünlü Tuba , Somi Mohammad Hossein 
Published: January 2022

Aim: This study aimed to accurately identification of potential miRNAs for gastric cancer (GC) diagnosis at the early stages of the disease.Methods: We used GSE106817 data with 2,566 miRNAs to train the machine learning models. We used the Boruta machine learning variable selection approach to identify the strong miRNAs associated with GC in the training sample. We then validated the prediction models in the independent sample GSE113486 data. Finally, an ontological analysis was done on identified miRNAs to eliciting the relevant relationships.Results: Of those 2,874 patients in the training the model, there were 115 (4%) patients with GC. Boruta identified 30 miRNAs as potential biomarkers for GC diagnosis and hsa-miR-1343-3p was at the highest ranking. All of the machine learning algorithms showed that using hsa-miR-1343-3p as a biomarker, GC can be predicted with very high precision (AUC; 100%, sensitivity; 100%, specificity; 100% ROC; 100%, Kappa; 100) using with the cut-off point of 8.2 for hsa-miR-1343-3p. Also, ontological analysis of 30 identified miRNAs approved their strong relationship with cancer associated genes and molecular events.Conclusion: The hsa-miR-1343-3p could be introduced as a valuable target for studies on the GC diagnosis using reliable biomarkers.
Genome-Wide Analysis of TIR-NBS-LRR Gene Family in Potato Identified StTNLC7G2 Inducing Reactive Oxygen Species in Presence of Alternaria solani
Authors: Dubey Namo , Chaudhary Anjali , Singh Kunal 
Published: January 2022

Resistance gene analogs (RGAs) comprising NBS-LRR gene family members are considered prominent candidates in the development of disease-resistant genotypes. NBS-LRR gene family comprised a very large number of genes; therefore, members of one subfamily TIR-NBS-LRR (TNL) are identified in the present study from Solanum tuberosum genome, followed by their bioinformatics characterization. The study identified a total of 44 genes encoding 60 TNL transcripts with two prominent clusters at chromosome 1 and chromosome 11. Expression analysis of 14 TNL genes after Alternaria solani infection at 1, 2, 3, 5, and 7 days post inoculation in two disease-tolerant varieties, Kufri Jyoti and Kufri Pukhraj, and one relatively susceptible variety, Kufri Chandramukhi, showed differential expression of many genes including a high expression (&gt;15-fold) of StTNLC6G2T1 and StTNLC11G9T1. Functional characterization of one such gene, StTNLC7G2, reveals involvement in the generation of reactive oxygen species under A. solani attack, implicating its putative role in plant defense via hypersensitive response.
Prevalence, Incidence, and Associated Factors of Possible Sarcopenia in Community-Dwelling Chinese Older Adults: A Population-Based Longitudinal Study
Authors: Chen Zi , Ho Mandy , Chau Pui Hing 
Published: January 2022

Purpose: This study aimed to assess the prevalence, incidence, and associated factors of possible sarcopenia in a nationwide representative sample of the community-dwelling older Chinese population.Methods:This study used the data of participants aged 60 years and over from the China Health and Retirement Longitudinal Study (CHARLS). Data on participants from three waves (2011–2015) of CHARLS were extracted. Possible sarcopenia was defined as low muscle strength or low physical performance, based on the Asian Working Group for Sarcopenia 2019 consensus. We first described baseline prevalence and four-year incidence of possible sarcopenia. Then multiple logistic regression and multivariable parametric proportional hazard model with Weibull distribution were used to examine the association of risk factors with baseline prevalence and four-year incidence of possible sarcopenia, respectively.Results:The prevalence of possible sarcopenia was 46.0%. The four-year incidence of possible sarcopenia was 11.9 per 100 person-years. Multivariable analysis revealed that advanced age and depressive symptoms were associated with increased prevalence of possible sarcopenia, while receiving education and moderate or high physical activity were associated with a lower risk of possible sarcopenia prevalence. For incidence, only advanced age was associated with an increased risk of possible sarcopenia incidence.Conclusion:Our study revealed the substantial burden of possible sarcopenia and related risk factors in community-dwelling settings in China. It highlighted the importance of early detection and intervention in this subclinical group for the prevention of sarcopenia.