bluuebunny/crossref_metadata_2025_split huggingface dataset:
A mean-end chain (MEC) lens of quality of care on customer equity, recommendations and revisit intention
Authors: Lai Kim Piew , Chong Siong Choy , Lin Binshan 
Published: February 2025

Purpose
This study aims to investigate how the quality of care (QOC) in terms of structure and process affects the equity customers have with them and their influences on the intention to revisit and recommend health-care providers.

Design/methodology/approach
The study gathers 200 (pilot) and 400 (mass) data to validate and assess the framework structurally using the means-end chain (MEC) model via AMOS 26.0.

Findings
Customers with substantial equity derived from QOC are more inclined to revisit and recommend health-care providers. In addition, customers who rely solely on QOC, i.e. disregarding the perceived worth of the brand, value and relationship equity, are less devoted than those who recognise the value offered by health-care providers.

Practical implications
Hospital management could formulate alternative hospital visit strategies that improve customer access to the health-care system by establishing a treatment charter, akin to informed consent, that explains the instrument and the procedure used for each treatment. It is essential to improve understanding by better communicating the functionalities of the equipment and facilities, as well as the medical benefits customers would gain from using them. Hospital staff, such as check-up assistants, might be trained to convey treatment benefits to customers in a more understandable manner.

Originality/value
To the best of the authors’ knowledge, this is likely the first study to link flow experience to QOC (structure and process), customer equity and the intention to revisit and recommend. This study contributes to the service literature and the MEC model by providing empirical evidence of QOC in enhancing customer equity and how customers perceive their intention to revisit and recommend.
Retail practices for plant-based meat alternatives in Italy
Authors: Samoggia Antonella , Rossi Giulia , Macaione Giuseppe , Guidotto Aurora 
Published: February 2025

Purpose This study explores in-store retail sales practices for alternative protein products in Italy, with a focus on plant-based meat alternatives (PBMAs) compared to conventional meat products. It also investigates PBMA across different brand and business protein orientations to uncover disparities in retail practices, with attention to conventional and discount retailing.Design/methodology/approach Data are collected in Bologna, a mid-size metropolitan area in Italy, during autumn 2023. The methodology involved conducting in-person store audits across ten supermarkets and hypermarkets. The data collected encompasses variables such as protein type, product format, price, promotions, product shelf placement and protein orientation. Data elaboration includes Analysis of variance (ANOVA) testing and multivariate linear regression.Findings Results support that retail management practices price PBMA higher, offer fewer promotions and place them in the “ready-to-eat” department versus the meat department, if compared to conventional meat products. This suggests that Italian retailers do not consider PBMA as a direct alternative to the meat, but rather as a distinct food product category with its own retail management practices. The study also reveals that PBMA brand and business protein-orientation management practices influence pricing and sales. Retailers’ managerial approach shapes PBMA sales and consumer purchasing behavior.Originality/value The study is pioneering research on retailers and PBMA, a rapidly expanding food category. It focuses on Italy, a country where interest in alternative protein products remains limited but shows significant potential for growth. Finally, it provides a detailed analysis of in-store retail food management practices balancing PBMA with conventional meat products.
Development of heavy-duty climbing robot with rust removing and recycling system for steel structures
Authors: Chu Yuanzhen , Sun Weipeng , Mou Pengcheng , Lin Qiuyu , Jiang Yong , Wang Shuangxi 
Published: February 2025

Purpose
Steel structures are easily corroded under coastal atmospheric environment due to high humidity and high saltwater spray. To extend service life of steel structure infrastructure, it is necessary to remove rust and apply paint on the steel structure once a year. However, existing wall-climbing sandblasting robots are difficult to work on narrow steel beams and cause serious environmental pollution. The purpose of this study is to design a robot that can effectively remove rust from narrow steel beams and reduce environmental impact to extend the service life of steel structure infrastructure.

Design/methodology/approach
The heavy-duty wall-climbing robot designed in this study can effectively solve the above problems. The robot achieves adjustable magnetic adsorption force of the permanent magnet adsorption through a novel switch design and can work flexibly and stably on narrow steel beams through a worm-like internal and external alternating motion structure. In addition, it is equipped with a sandblasting recovery device to reduce environmental pollution.

Findings
The on-site test results on steel beams show that trust removal level can reach Sa2.0. The recovery rate of sandblasting and rust removal is close to 95%. The robot can carry a 40 kg sandblasting equipment and move at a speed greater than 40 cm/min, indicating that it can efficiently complete the rust removal work of narrow steel structures.

Originality/value
The originality lies in the design of the robot with features such as adjustable magnetic adsorption, special motion structure for narrow beams and a sandblasting recovery device. The value is that it can solve the problems of existing robots in working on narrow steel beams and environmental pollution and effectively extend the service life of steel structure infrastructure by efficiently removing rust.
Flavokawain A Ruthenium‐p‐Cymene Complex‐Induced Apoptosis by the Modulation of PI3K/β‐Catenin/HER2/PARP Signalling in Lung Cancer
Authors: Gayen Sakuntala , Roy Souvik , Laishram Diana , Bandyopadhyay Soumendra Nath , Mukherjee Swarupananda 
Published: February 2025

ABSTRACTLung cancer is most terrible cause of cancer‐related death throughout the world. This study focused on the synthesis and characterisation of novel flavokawain A ruthenium‐p‐cymene complex and to investigate the chemotherapeutic activity against lung carcinoma via in silico, in vitro and in vivo approaches. The complex was characterised via several spectroscopic techniques. In vitro study including cell viability, transwell migration, Western blot and flow cytometric analysis have been executed on both A549 and NCI‐H460 cells. The toxicological assessment was performed and subsequently anticancer activity of complex was evaluated in benzo[α]pyrene persuaded lung carcinoma in mice. The molecular docking study demonstrated the compound has greater binding ability with β‐catenin, Akt, HER2 and PARP. Followed by the complex treatment, the downregulation of β‐catenin, PI3K, Akt, HER2 and PARP were investigated by Western blot analysis and cell cycle arrest was determined through flow cytometry. The outcomes of in vivo experimentation represented fruitful restoration of typical lung architecture after complex treatment. Immunohistochemical analysis demonstrated the downstream of β‐catenin/m‐TOR/Akt and upstream of caspase‐3 and p53 expression, thereby initiating apoptosis. The complex exhibited a potent chemotherapeutic activity via the alteration of tumour microenvironment by modulating PI3K/Akt/β‐catenin/HER2/PARP transduction in correlates with apoptotic events in lung carcinoma.
Critical conversations: How marriage and family therapists begin exploring topics of race, gender and social justice
Authors: Marroquin Crystal G. , Morris Katherine L. , Triplett Nicholas T. , Lee Chorong , Kimmes Jonathan G. 
Published: February 2025

AbstractAs systemic practitioners, it is vital that marriage and family therapists continually develop their knowledge of how larger oppressive systems impact their clients. The purpose of this study was to explore how therapists approach the critical topics of race, gender and social justice in therapy. To expand on existing research, the present study utilised a qualitative thematic analysis to examine the experience of eleven marriage and family therapists (MFTs) of varying experience levels. Graduate students (n = 6), professors (n = 4) and clinicians in private practice also working as faculty (n = 1) were included. Results showed evidence of five themes which included: Personhood of the Therapist, Critical Mindset, Therapist Anxiety and Fear of Marginalisation, Effective Intervention and The Role of Supervision. This study contributes to expanding the literature on how therapists can provide culturally sensitive therapy, aid in evolving therapeutic techniques and work to improve therapeutic outcomes.
Standardised Methods for Developing Conceptual Frameworks for Placental Disorders of Pregnancy: Pre‐Eclampsia and Stillbirth
Authors: Elawad Terteel , Woo Kinshella Mai‐Lei , Stokes Ellie , Pickerill Kelly , Piagge Elisa Dalle , Vidler Marianne , Stanley Ella , Volvert Marie‐Laure , Bone Jeffrey N. , Elwell Helen , Mistry Hiten D. , Mateljan Violet , Tsigas Eleni , Filippi Veronique , von Dadelszen Peter , Blencowe Hannah , Magee Laura A. ,   PRECISE Network
Published: February 2025

ABSTRACTBackgroundRisk factors for the placental disorders of pregnancy (pre‐eclampsia, fetal growth restriction, preterm birth, and stillbirth) are complex, frequently involving the interplay between clinical factors and wider social and environmental determinants of health. Biomarkers modulate the maternal and fetal responses to biological processes that underlie the development of placental disorders.ObjectivesTo develop a standardised methodology to assess the importance of, and inter‐relationships between, candidate risk factors for the various placental disorders.Search StrategySystematic searches were conducted using Medline, Embase, Health Technology Assessments, Database of Abstracts of Reviews of Effects, Cochrane Library databases, Google Scholar, and reference lists of retrieved papers.Selection CriteriaWe deployed a hierarchy of reviews, systematic reviews, and cohort studies with at least 1000 participants (100 for biomarker studies), published in the prior decade.Data Collection and AnalysisWe assessed the strengths of association and quality of evidence linking risk factors with individual placental outcomes.ConclusionsWe have developed a standardised approach to assess the importance and inter‐relatedness of putative risk factors for the placental disorders of pregnancy.
Feasibility of a targeted nutrition‐risk screening tool in Australian mental health services: The NutriMental screener
Authors: Teasdale Scott B. , Ardill‐Young Oliver , Crawford Patricia , Gould Patrick , Hennessy Erikka , Inall Bronwyn , King Sarah , Lancaster Rebecca , Millett Olivia , Pearson Abbey , Roen Julia , Strong Alyssa , Surdut Mark , Burrows Tracy , Curtis Jackie , Ward Philip B. , Mueller‐Stierlin Annabel Sandra 
Published: February 2025

AbstractAimsThis study aimed to test the feasibility and acceptability of mental health clinicians using a multifaceted nutrition‐risk screening tool in Australian mental health settings.MethodsA mixed‐methods cross‐sectional design was used. Mental health clinicians implemented the multifaceted NutriMental screener at seven sites across Australia and provided feedback via a standardised form. Primary outcomes were the feasibility, acceptability and appropriateness domains of the feedback questionnaire. Additional outcomes included association/agreement between the consumer's desire for dietetic support, clinicians' impression of need for dietetic support, and total nutrition risks reported. Directed content analysis was employed to analyse open‐ended sections of the clinician feedback questionnaire.ResultsFifty‐four clinicians participated, completing the NutriMental screener with a total of 256 mental health consumers. Mean total nutrition risks reported were 6.4 ± 1.8 (out of nine). Mean implementation outcomes (out of five) were 3.1 ± 0.8 for acceptability, 3.7 ± 0.5 for appropriateness, and 4.3 ± 1.7 for feasibility. There was moderate agreement between consumer's desire for dietetic support and clinicians' impression of need for dietetic support κ = 0.32 (95% CI: 0.21–0.43), p < 0.001, and positive correlations between the number of nutrition risks reported and consumer's desire for dietetic support (r = 0.29, p < 0.001) and clinicians' impression of need for dietetic support (r = 0.29, p < 0.001). Six themes and 17 subthemes related to barriers and facilitators to the screener's implementation were identified.ConclusionThe multifaceted risk screening tool appears to be feasible, acceptable and appropriate for use within Australian mental health services. Refinements of the NutriMental screener based on clinician feedback may further improve its implementation.
A New Method for Constructing High‐Resolution Phylogenomic Topologies Using Core Gene‐Associated MNP Markers: A Case Study From Agaricus bisporus
Authors: Liu Fei , Cai Zhi‐Xin , Kang Wen‐Yi , Chen Wen‐Zhi , Lu Yuan‐Ping , Chen Mei‐Yuan , Zhao Rui‐Lin 
Published: February 2025

ABSTRACTAccurate strain identification is essential for economically significant fungi, as it aids in understanding their diverse agronomic traits, pathogenicity, and other important characteristics. However, traditional methods often face challenges related to limited accuracy, high workloads, and reproducibility issues. Recently, multiple nucleotide polymorphism (MNP) markers have been employed in mushroom strain identification, demonstrating significantly improved accuracy and reproducibility. Nevertheless, the identification of strains across different species still heavily depends on specific and often overly complex MNP markers. In this study, we address these challenges by developing a novel method for constructing high‐resolution phylogenomic topologies using core gene‐associated multiple nucleotide polymorphism (cgMNP) markers, focusing on Agaricus bisporus (button mushroom). Utilising resequencing data from 213 cultivated and wild strains of A. bisporus, we identified 84 cgMNP markers within 83 core genes from 1011 MNP markers. Phylogenetic analysis based on cgMNP sequences and the genetic distance between strain pairs allowed for precise identification of all strains. Moreover, the successful transferability of these cgMNP markers to an additional 385 A. bisporus strains and other fungal species, including Flammulina filiformis (enoki mushroom) and Saccharomyces cerevisiae (yeast), highlights their cross‐species applicability. The high resolution and strong congruence of cgMNP markers with whole‐genome data provide a robust and reliable method for strain‐level discrimination in fungi. The success of this approach in A. bisporus sets a promising precedent for its application to a broader range of fungal taxa.
Testing Soil Moisture Performance Measures in the Conceptual‐Functional Equivalent to the WRF‐Hydro National Water Model
Authors: Araki Ryoko , Ogden Fred L. , McMillan Hilary K. 
Published: February 2025

ABSTRACTThe Conceptual‐Functional Equivalent (CFE) to the National Water Model (NWM) serves as a baseline rainfall‐runoff model in the National Oceanic and Atmospheric Administration (NOAA)'s Next Generation National Water Model Framework (NextGen). The CFE model performs similarly to the earlier version of the NWM, allowing comparisons with new models introduced in future versions. In addition to streamflow, the NWM outputs other hydrologic variables including soil moisture. Soil moisture plays a key role in simulating seasonal hydrologic processes in process‐based models; therefore, it is imperative to evaluate models against observed data. However, incorporating in situ observed soil moisture data, which is highly spatially variable, into the calibration process may compromise streamflow results. We investigate how model evaluation, including in situ soil moisture observations, affects CFE's ability to reproduce streamflow and soil moisture. We evaluated the CFE model on two experimental watersheds using both traditional and signature‐based performance metrics for soil moisture. Results showed that including soil moisture data enhances the reproducibility of overall and seasonal soil moisture patterns without sacrificing the reproducibility of streamflow. Calibration against streamflow alone was insufficient to reproduce soil moisture patterns. We recommend including soil moisture metrics when available in the CFE model calibration to improve seasonal streamflow predictions.
Nutrient Runoff From Agricultural Lands in North American Ecoregions
Authors: Hopkins A. P. , Harmel R. D. , Kleinman P. J. A. , Sahoo D. , Ippolito J. A. 
Published: February 2025

ABSTRACTField‐scale runoff and water quality data are critical to understanding the fate of agricultural nutrients and mitigating their off‐site transport; however, regional influences such as precipitation, temperature, and prevailing cropping and management practices also impact nutrient runoff. In the present study, we used the recently updated MANAGE database to conduct meta‐type analyses of nitrogen (N) and phosphorus (P) in runoff from cropland and grasslands for North American ecoregions. Specifically, we analyzed annual N and P loads and the impact of land use, tillage, fertilizer timing, and fertilizer placement. Notable differences between ecoregions included: (1) the Temperate Prairies dominated by highly erodible cultivated land had significantly higher median annual total N loads (11.7 kg/ha) than the South Central Semiarid Prairies (2.4 kg/ha) dominated by grasslands; (2) corn production tended to produce higher N and P loads than other land uses in the Mixed Wood Plains, Southeastern USA Plains, and Ozark–Ouachita/Appalachian Forests; and (3) no‐till had the highest dissolved P loads in the Southeastern USA Plains and Temperate Prairies, but conventional tillage had the highest dissolved P loads in the Ozark–Ouachita/Appalachian Forests. These data—that have never before been analyzed by ecoregion—should prove valuable for improving regional understanding of nutrient fate and transport and informing field‐scale agricultural management decisions.
Over‐ and Under‐ Representations of Predatory Fish Body Sizes Are Shaped by Habitat Architecture and Nutrient Loads in a Subtropical River Basin
Authors: Maresca Urioste Felipe , Borthagaray Ana Inés , González‐Bergonzoni Ivan , Arim Matías 
Published: February 2025

ABSTRACTBody size distribution reflects the ecological and evolutionary mechanisms that shape biodiversity. Over‐ and under‐representations ‐i.e., discontinuities‐ in this distribution reflect body sizes that could be favoured or limited by operating mechanisms. Although several non‐exclusive hypotheses have been formulated to explain the discontinuities in body size distributions, few empirical studies have been able to advance on the determinants of these discontinuities along ecological gradients. By means of null models we assessed the existence of over‐/under‐ representations in the body size distribution of 48 local assemblages of carnivorous fishes in the Rio Negro basin, Uruguay. Specifically, we identified the body size locations at which an over‐representation and/or under‐representation occurs in local communities compared to the null model distribution. Then, using Structural Equation Modelling (SEM), we explicitly connect these deviations with gradients in local conditions. Over‐representations at the different sites ranged from sizes of 0.1 to 28.8 g, while under‐representations ranged from 0.1 to 27.1 g. Our structural equation model identified a significant connection between substrate type and nutrient loads with the location of over‐representations in the size spectra, while substrate type and depth were connected to the magnitude of the over‐representation. The magnitude of the over‐representation influenced the size and magnitude of the under‐representation. Local environmental variables exhibited strong influence on the body size distribution, being favoured over the connectivity of communities. This suggests that local filtering has a preponderant role in explaining the dependence of species performance on body size in this system. The present study highlights the existence of discontinuities in the distribution of traits in general and body size in particular as a relevant feature of biodiversity organisation, seldom considered in empirical studies. Advancing on the local and regional determinants of these features emerges as a powerful and complementary approach for unravelling the mechanisms behind biodiversity assembly and functioning.
Predictive Biomarkers and Personalized Therapy: Use of Pharmacogenetic Testing in a Scandinavian Perspective
Authors: Westergaard Niels , Lund Trine Meldgaard , Vermehren Charlotte 
Published: February 2025

ABSTRACTPrecision medicine has significantly advanced through the development of predictive biomarkers based on pharmacogenetic (PGx) testing. These tests identify interactions between drugs and genetic variants that influence patient responses to treatments. Understanding genetic variations in drug‐metabolizing enzymes, receptors and transporters and their impact on pharmacokinetics and pharmacodynamics allows for the prediction of drug effects and side effects, enabling tailored treatments for different patient groups. This review focuses on drugs metabolized by cytochrome P450 (CYP450) enzymes, for example, citalopram and clopidogrel or transported by the solute carrier organic anion transporter family member 1B1 (SLCO1B1), for example, atorvastatin and simvastatin, with PGx dosing guidelines, in the context of consumption in Scandinavian countries. A major barrier to the widespread adoption of PGx tests in clinical practice has been healthcare professionals' uncertainty about their efficacy, complexity in result interpretation and questions regarding the evidence base. However, recent studies have demonstrated PGx testing has the potential to improve treatment outcomes, reduce adverse drug reactions and achieve cost savings. These findings underscore the potential of PGx testing as a valuable tool in clinical decision making, promoting its use in a pre‐emptive manner to enhance patient care.
Longitudinal analysis of lentiviral and retroviral chimeric antigen receptors' integration sites reveals distinct clonal evolutionary patterns
Authors: Guiraud Vincent , Denis Jerome Alexandre , Benhafoun Ghizlane , Ablin Erwan , Sayon Sophie , Souchet Laetitia , Azar Nabih , Grenier Adrien , Metz Carole , Legrand Ronan , Marcelin Anne‐Geneviève , Choquet Sylvain , Calvez Vincent , Todesco Eve 
Published: February 2025

SummaryT‐cell malignancies following chimeric antigen receptor (CAR) therapies are partly related to insertional mutagenesis, but the longitudinal evolution of CAR‐integration sites (IS) remains understudied. We performed an IS analysis in blood from three tisagenlecleucel (lentiviral), one axicabtagene‐ciloleucel and one brexucabtagene‐autoleucel (gammaretrovirals) patient at peak expansion and 1‐year follow‐up. All were complete responders. Peak expansion IS patterns were vector dependent: lentiviral CAR integrated mostly in introns and gammaretrovirals in intergenic regions, closer to transcription start sites. At 1‐year post‐infusion, lentiviral CAR showed no major clonal proliferation. Gammaretroviral CARs had divergent outcomes: no detectable CAR (axicabtagene‐ciloleucel) or low‐level oligoclonal persistence (brexucabtagene‐autoleucel). Whether this latter evolution is at risk of further CAR malignancies needs further investigations.