bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of bergamot (KoksalGarry) supplementation on lipid profiles: A systematic review and meta‐analysis of randomized controlled trials
Authors: Sadeghi‐dehsahraei Hamed , Esmaeili Gouvarchin Ghaleh Hadi , Mirnejad Reza , Parastouei Karim 
Published: October 2022

AbstractThis systematic review and meta‐analysis were conducted to evaluate the impact of bergamot (KoksalGarry) and its nutraceutical compounds on lipid profiles. PubMed, Web of Knowledge, Scopus, and Google Scholar searched for relevant articles. Trials investigating the effect of oral bergamot supplementation on serum levels of total cholesterol (TC), triglyceride (TG), low‐density lipoprotein cholesterol (LDL‐C), and high‐density lipoprotein cholesterol (HDL‐C) in adults were included. The mean differences and standard deviations were pooled using a random‐effects model. Fourteen trials were included in this systematic review and meta‐analysis. Bergamot supplementation significantly decreased serum levels of TC (weighted mean difference (WMD): −63.60 mg/dL; 95% CI: −78.03 to −49.18; p < .001), TG (WMD: −74.72 mg/dL; 95% CI: −83.58 to −65.87; p < .001), LDL‐C (WMD: −55.43 mg/dL; 95% CI: −67.26 to −43.60; p < .001), and increased HDL‐C (WMD: 5.78 mg/dL; 95% CI: 3.27 to 8.28; p < .001), respectively. Our systematic review of the effects of nutraceuticals containing bergamot on lipid markers showed inconsistent results. The results showed that bergamot supplementation might improve lipid profiles. The findings for nutraceutical compounds containing bergamot were inconsistent. However, the clinical efficacy of bergamot on lipid profiles needs to be further established through higher‐quality studies.
Chinese dragon's blood ethyl acetate extract suppresses gastric cancer progression through induction of apoptosis and autophagy mediated by activation of MAPK and downregulation of the mTOR‐Beclin1 signalling cascade
Authors: Ouyang Lishan , Li Jiaqi , Chen Xiaonan , Huang Huiming , Tian Yingying , Li Xingxing , Pang Daoran , Wei Xuejiao , Xie Jinxin , Wang Longyan , Liu Dongxiao , Tu Pengfei , Li Jun , Hu Zhongdong 
Published: October 2022

AbstractGastric cancer (GC) is a malignancy with high morbidity and mortality. Chinese dragon's blood is a traditional Chinese medicine derived from the red resin of Dracaena cochinchinensis (Lour.) S. C. Chen. However, the antigastric cancer effect of Chinese dragon's blood has not yet been reported. Herein, we demonstrated that Chinese dragon's blood ethyl acetate extract (CDBEE) suppressed the proliferative and metastatic potential of human gastric cancer MGC‐803 and HGC‐27 cells. CDBEE suppressed epithelial–mesenchymal transition in MGC‐803 and HGC‐27 cells. Moreover, CDBEE induced apoptotic and autophagic cell death in MGC‐803 and HGC‐27 cells. The cytotoxicity of CDBEE in human gastric epithelial GES‐1 cells was dramatically weaker than that in human gastric cancer cells. Mechanistically, the activation of the mitogen‐activated protein kinase (MAPK) signalling pathway was involved in the growth inhibition of MGC‐803 and HGC‐27 cells by CDBEE. Additionally, CDBEE‐induced autophagic cell death was mediated by downregulation of the mammalian target of rapamycin (mTOR)‐Beclin1 signalling cascade and upregulation of the ATG3/ATG7‐LC3 signalling cascade. Importantly, CDBEE exhibited potent anti‐GC efficacy in vivo without obvious toxicity or side effects. Therefore, CDBEE may be a promising candidate drug for the treatment of gastric cancer, especially for GC patients with aberrant MAPK signalling or mTOR signalling.
The impacts of putting the Zaporizhzhia Nuclear Power Plant in the line of fire
Authors: Tsagkaris Christos , Matiashova Lolita , Isayeva Anna 
Published: October 2022

AbstractThe armed forces of the Russian Federation captured the Zaporizhzhia Nuclear Power Station after their invasion to Ukraine in February 2022. In early August 2022, reports about shelling of the station ignited fear of a nuclear accident. Simultaneously, the disruption in the generation of electricity from nuclear energy has fueled a notable increase in the price of oil. The compounding effect of these developments on global health includes acute and chronic radiation exposure, food insecurity due to the potential contamination of the environment and the rise in the cost of essential commodities, and limited access to healthcare. International and national governance bodies need to take action in order to mitigate the effects of this incident on health and prevent similar events in the future.
Understanding the molecular mechanisms of macrophage polarization and metabolic reprogramming in endometriosis: A narrative review
Authors: Kobayashi Hiroshi , Imanaka Shogo 
Published: October 2022

AbstractBackgroundEndometriosis is an estrogen‐dependent disease and causes pelvic pain and infertility. The limits of current pharmacotherapy in women who desire to become pregnant prompt the development of various targeted molecules for more effective treatment. A review article focused on the unique aspect of cellular metabolic reprogramming of endometriotic cells has been reported. The cellular metabolic pathways are reprogrammed to adapt to a variety of environmental stresses (e.g., nutrient starvation or glucose deprivation, hypoxic stress, excessive reactive oxygen species generation, and other environmental factors). This review aims to summarize macrophage polarization and metabolic reprogramming in endometriosis.MethodsA literature search was performed between January 2000 and March 2022 in the PubMed and Google Scholar databases using a combination of specific terms.ResultsMacrophage cellular metabolism has a marked influence on its phenotype and function. Preclinical studies showed that metabolic conversion toward glycolysis or oxidative phosphorylation drives macrophage polarization to M1 or M2 phenotype, respectively. Such cellular metabolic rewiring can offer new therapeutic opportunities.ConclusionA better understanding of metabolic reprogramming biology in endometriosis‐associated macrophages is essential in considering novel therapeutic approach for endometriosis. However, there are currently no detailed studies on therapeutic strategies targeting the cellular metabolic properties of endometriosis‐associated macrophages.
Fixed‐time distributed optimization for multi‐agent systems with external disturbances over directed networks
Authors: Yu Zhiyong , Sun Jian , Yu Shuzhen , Jiang Haijun 
Published: October 2022

AbstractThis article considers the fixed‐time distributed optimization problem of multi‐agent systems with external disturbances, in which the global optimization objective is a convex combination of local objective functions. To solve this issue, a directed communication network is carefully designed, and an integral sliding mode control protocol is proposed based on the gradient of global objective function first. Moreover, two distributed optimal protocols are designed by using the gradient and the Hessian matrix of local objective function, respectively. By employing Lyapunov stability theory, graph theory, convex analysis, and inequality techniques, we prove that all proposed protocols can make agents achieve consensus and converge accurately to the optimal solution of the considered problem in some fixed‐time intervals. Finally, some numerical simulations are given to verify the feasibility of the theoretical results.
P‐2.12: Application status and prospect of mixed reality in medical surgery
Authors: Zhao Sensen , Wang Lijun , Song Jianwen 
Published: October 2022

The full text illustrates the specific application progress and application results of mixed reality technology in medical surgery by cite the case of the combination of mixed reality and medical surgery, and points out that mixed reality technology plays an important auxiliary role in medical surgery and can help accurate surgery. Positioning, precise operation, shortening the operation time, reducing blood loss and so on. Based on the above advantages, the application prospect of mixed reality technology in the field of medical surgery is very broad, and more and more scientific researchers are required to explore this aspectMixed reality technology can assist doctors in surgical operations, and has the main advantages of accurate positioning, precise operation, shortening the operation time, and reducing blood loss. More and more scientific researchers are required to continue to research and develop more applications that assist medical operations to proceed smoothly.
Facile synthesis of two‐dimensional PA‐Ag@C film for highly sensitive SERS detection
Authors: Li Anqi , Xin Xiaoli , Zhang Tingting , Xu Tao , Li Luo , Liu Chang , Li Weihua , Li Jiansheng , Li Yi , Lu Rui 
Published: October 2022

In this study, the surface of polyamide (PA) films are electrostatically deposited with the carbon‐coated silver (Ag@C) nanoparticles, resulting in a two‐dimensional (2D) PA‐Ag@C film substrate. The TEM images demonstrate that the nanoparticles were successful synthesized. By adjusting the pH of the system, the core–shell structure and the 2D SERS substrate work together to improve the sensitivity, stability, and repeatability of the substrate to be used in complex real‐world water samples. The SERS enhancement effect and substrate uniformity were determined using rhodamine 6G (R6G), crystal violet (CV), and malachite green (MG). The results indicate that the 2D PA‐Ag@C film substrate in this study has the optimal Raman effect at a system pH of 6. Under ideal pH conditions, the R6G detection limit (LOD) is as low as 10−10 M (D2 attenuation), and the Raman signal intensity deviation of the same substrate is maintained within 9.49%. Overall, the Raman signal of probe molecule on the fabricated PA‐Ag@C film possesses excellent sensitivity, repeatability, and stability.
Reliability Analysis of a Novel Measurement System for Quantifying Human Skin Color
Authors: Chen Chien-Chung , Chung Cheng-Yin , Chiu Yi-Wen , Lin Yu-Hsuan , Tse Ling-Shan , Wu Ching-Ying , Hwang Shang-Jyh , Lin Ming-Yen 
Published: October 2022

Abstract

Background
Precision is crucial in determining the appropriate procedure for implementing further trials. We conducted a study to explore the reliability of a novel measuring system for human skin color.

Methods
The novel skin color measuring system was used to capture the skin color of four volunteers (2 males and 2 females) from the same location on each subject by the same operator. The measurement was repeated for different poses and instrument factors (camera and shooting protocol) in the red, green, and blue (RGB) system. The average color depth in each image was calculated and converted from 0 to 255. The spread of measures and the Bland-Altman plot was displayed to determine each variance source's random error, with the interclass correlation coefficients applied to reflect the reliability.

Result
The RGB color depth in the experiment ranged from 190, 152, and 122 to 208, 170, and 142. The 95% confidential interval of the differences from the means in RGB colors for the different protocols were ±2.8, ±2.6, and ±2.1, respectively. The largest variation in the replicate trials was observed when subjects were in a supine position (standard deviation: 2). The interclass correlation coefficients were greater than 90%, suggesting that the developed system is highly precise.

Conclusion
This study demonstrated that the developed device could stably and reliably detect human skin color across different common sources of variation, and thus could be applied clinically to explore relationships between health/disease and skin color changes.
Information overload's double‐edged sword effect on sense of safety: Examining the moderating role of hypervigilance
Authors: Zhang Wen , You Yue , Wang Lei , Liu Wei , Zhang Xichao 
Published: October 2022

AbstractSince the COVID‐19 pandemic outbreak, long‐term overlooked motives concerning a sense of safety have become a primary concern. People's sense of safety largely depends on the information they receive. Indeed, a tsunami of information about the virus has been disseminated by all forms of media to people's electronic devices, thus permeating their lives. This study proposed that the over‐abundance of information, known as information overload, could endanger individuals' sense of safety by increasing their rumination about COVID‐19. However, it could also enhance their sense of safety by increasing their positive attitudes toward COVID‐19 precautions. Furthermore, we proposed that individuals' hypervigilance could strengthen the relationship between information overload and rumination about COVID‐19 and attitudes toward COVID‐19 precautions. We tested these hypotheses using a cross‐sectional survey study (N = 403) in February 2021 and a diary study (N = 98) in July 2021 in China. The results of both studies support the dual mediating paths of the relationship between information overload and sense of safety. We also found that hypervigilance moderated the relationship between information overload and rumination about COVID‐19. Overall, our study offers insights into how social media may influence people's sense of safety and how individual differences in hypervigilance play a role in the process.
On‐Chip Investigation of Electrocatalytic Oxygen Reduction Reaction of 2D Materials
Authors: Qi Junlei , Wang Wenbin , Li Yihan , Sun Yamei , Wu Zongxiao , Bao Kai , Wang Lingzhi , Ye Ruquan , Ding Mengning , He Qiyuan 
Published: October 2022

AbstractThe on‐chip electrocatalytic microdevice (OCEM) is an emerging platform specialized in the electrochemical investigation of single‐entity nanomaterials, which is ideal for probing the intrinsic catalytic properties, optimizing performance, and exploring exotic mechanisms. However, the current catalytic applications of OCEMs are almost exclusively in electrocatalytic hydrogen/oxygen evolution reactions with minimized influence from the mass transfer. Here, an OCEM platform specially tailored to investigate the electrocatalytic oxygen reduction reaction (ORR) at a microscopic level by introducing electrolyte convection through a microfluidic flow cell is reported. The setup is established on gold microelectrodes and later successfully applied to investigate how Ar‐plasma treatment affects the ORR activities of 2H MoS2. This study finds that Ar‐plasma treatment significantly enhances the ORR performance of MoS2 nanosheets owing to the introduction of surface defects. This study paves the way for highly efficient microscopic investigation of diffusion‐controlled electrocatalytic reactions.
Highly Dispersed Ru–Co Nanoparticles Interfaced With Nitrogen‐Doped Carbon Polyhedron for High Efficiency Reversible Li–O2 Battery
Authors: Tong Zhen , Lv Chao , Zhou Yao , Zhang Peng‐Fang , Xiang Cheng‐Cheng , Li Zhen‐Gang , Wang Zhen , Liu Zong‐Kui , Li Jun‐Tao , Sun Shi‐Gang 
Published: October 2022

AbstractThe lithium–oxygen (Li–O2) battery with high energy density of 3860 Wh kg−1 represents one of the most promising new secondary batteries for future electric vehicles and mobile electronic devices. However, slow oxygen reduction/oxygen evolution (ORR/OER) reaction efficiency and unstable cycling performance restrain the practical applications of the Li–O2 battery. Herein, Ru‐modified nitrogen‐doped porous carbon‐encapsulated Co nanoparticles (Ru/Co@CoNx–C) are synthesized through reduction of Ru on metal–organic framework (MOFs) pyrolyzed derivatives strategies. Porous carbon polyhedra provide channels for reactive species and stable structure ensures the cyclic stability of the catalyst; abundant Co–Nx sites and high specific surface area (353 m2 g−1) provide more catalytically active sites and deposition sites for reaction products. Theoretical calculations further verify that Ru/Co@CoNx–C can regulate the growth of Li2O2 to improve reversibility of Li–O2 batteries. Li–O2 batteries with Ru/Co@CoNx–C as cathode catalyst achieve small voltage gaps of 1.08 V, exhibit excellent cycle stability (205 cycles), and deliver high discharge specific capacity (17050 mAh g−1). Furthermore, pouch‐type Li–O2 batteries that maintain stable electrochemical performance output even under conditions of bending deformation and corner cutting are successfully assembled. This study demonstrates Ru/Co@CoNx–C catalyst's great application potential in Li–O2 batteries.
Relationship among Extrusion Conditions, Cell Morphology, and Properties of Starch‐Based Foams—A Review
Authors: Dircio‐Morales Marco Antonio , Fonseca‐Florido Heidi Andrea , Velazquez Gonzalo , Ávila‐Orta Carlos Alberto , Ramos‐De Valle Luis Francisco , Hernández‐Gámez Francisco , Rivera‐Salinas Jorge Enrique , Soriano‐Corral Florentino 
Published: October 2022

AbstractEnvironmental impact concern of conventional polymer foams has attracted considerable interest for the development of natural‐based polymer foams. Starch is a biopolymer that is gaining acceptability due to its renewability, availability, environmental biodegradation, and low cost. Extrusion is particularly desirable to produce starch‐based foams because it can produce a homogeneous mixing, high heat transfer, high pressure, reduction of the residence time, and low production costs. This review explains the transformation of starch during the foam processing and their relationship with extrusion conditions such as water content, barrel temperature, screw configuration and speed, die temperature, and die dimensions and how all these factors impact on the cell morphology, apparent density, expansion ratio, and final properties of starch‐based foams. The strategies to reduce water sensitivity are described, as well as the effect of amylose content and the addition of additives to improve the starch‐based foams performance as alternative for expanded polystyrene. The extrusion processing conditions can be controlled to obtain the desirable properties for specific applications such as cushioning, packaging, and loose‐fill, among others. Also, a brief look at the starch‐based foams trends, challenges, and perspectives are also discussed.
Impact of crumb rubber particle size on the mechanical and microstructure properties of rubberized concrete
Authors: Mo Jinxu , Ren Fengming , Tian Shiyu , Wang Qing , Ho Johnny Ching Ming 
Published: October 2022

AbstractCrumb rubber (CR) concrete (CRC) characterized with high ductility and environment friendliness, has recently been studied widely in the field of green concrete. Generally, high volume fraction of CR in cementitious system leads to low strength. However, the effect of CR particle size has not been concluded yet. This paper focuses on the impact of CR size on the mechanical and microstructure properties of CRC. Two novel substitution approaches of CR for natural fine aggregate are adopted. In total, 10 groups are designed and experimentally tested for their workability in fresh state and mechanical properties in hardened state. Brittleness coefficient, fineness modulus, and micro‐morphology of CRC were analyzed and discussed. Results show that as size of CR decreases, workability improves significantly, apparent density and strength exhibit a firstly decrease and then increase trend, with the lowest value obtained around 1.18 mm CR size. The brittleness of concrete was significantly improved in the presence of CR, and the improvement was more significant for smaller‐sized CR. Weak ITZs between CR particles and interfacial porosity are the main reasons for the sharp strength deterioration. Crack arresting effect of CR makes the crack propagation path more tortuous, and smaller particle‐sized CR exhibits greater capability.
Partnering with Families to Use Screen Time for Supporting Early Language and Literacy
Authors: Tatar Burcu H. , Gerde Hope K. 
Published: October 2022

AbstractYoung children's engagement with digital tools (e.g., tablets, smartphones, ebooks/storyapps, and mobile apps) is increasing globally. This is inevitable in our digital world. Even though children primarily use digital technology for entertainment purposes, these tools offer valuable learning opportunities too. Importantly, adults can provide and engage children with digital tools that support and enhance their language and early literacy skills. This article identifies the ways teachers can guide families to select quality digital media and interact with their young children as they use digital technologies to support children's language, reading, and writing development. The authors encourage teachers to engage families as their partners in children's learning within digital spaces. Example family handouts support teachers to connect with families about using technology in ways that promote children's language and literacy development.
The physiological dissimilarities of Holstein dairy cows with different milk yields
Authors: Dong Jianan , Liu Yongjun , Li Songze , Sun Zhe , Chen Xue , Wang Duojia , Qin Guixin , Zhang Xuefeng , Aschalew Natnael Demelash , Wang Tao , Zhen Yuguo 
Published: October 2022

AbstractBackgroundEven if breed, parity, dietary and environmental management are same, dairy cows still have notable differences in milk yield that may be underpinned by physiologic differences.ObjectivesThis study aimed to investigate the physiological dissimilarities of dairy cows with different milk yields.MethodsThirty cows were sorted into high milk‐yielding cows (group H: 58.93±2.31 kg/day), moderate milk‐yielding cows (group M: 44.99±0.54 kg/day), and low milk‐yielding cows (group L: 24.99±6.83 kg/day) according to milk yield. Blood was collected and serum parameters were assessed. Rumen fluid was collected for the evaluation of rumen fermentation parameters (RFPs) and bacterial community composition (BCC).ResultsSerum prolactin, growth hormone, glutathione peroxidase, immunoglobulin A and non‐esterified fatty acid had a significantly positive correlation with milk yield (p < 0.05), whereas serum glucagon and total antioxidant capacity had a significantly negative correlation with milk yield (p < 0.05). The concentration of valeric acid and the ratio of acetic acid to propionic acid in the rumen fluid in group H was significantly lower than that in group L (p < 0.05). The concentration of acetic acid and butyric acid in group H was significantly lower than that in groups M and L (p < 0.05). The relative abundances of Ruminococcaceae_NK4A214_group, Prevotella_1, Rikenellaceae_RC9_gut_group, Christensenellaceae_R‐7_group, Muribaculaceae, and Ruminococcus_2 were negatively correlated with milk yield, whereas the relative abundance of Succinivibrionaceae_UCG‐001, Lachnospiraceae_NK3A20_group, Shuttleworthia and Dialister were positively correlated with milk yield (p < 0.05).ConclusionsThis study indicates that dairy cows with different milk yields have clear divergence in serum indicators, RFPs, BCC and rumen microbial metabolism.