bluuebunny/crossref_metadata_2025_split huggingface dataset:
When the “Ostjuden” Returned: Linguistic Continuities in German-Language Writing about Eastern European Jews
Authors: Kałczewiak Mariusz 
Published: January 2022

Abstract
This article examines the dynamics that allowed the derogatory term “Ostjuden” to reappear in academic writing in post-Holocaust Germany. This article focuses on the period between 1980’s and 2000’s, complementing earlier studies that focused on the emergence of the term “Ostjuden” and on the complex representations of Eastern European Jews in Imperial and later Weimar Germany. It shows that, despite its well-evidenced discriminatory history, the term “Ostjuden” re-appeared in the scholarly writing in German and has also found its way into German-speaking public history and journalism. This article calls for applying the adjectival term “osteuropäische Juden” (Eastern European Jews), using a term that neither essentializes Eastern European Jews nor presents them in an oversimplified and uniform manner.
Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents
Authors: Singh Arvind , Basu Amartya , Sharma Aditi , Priya Anu , Kaur Manmmet , Kaur Gurpreet , Banerjee Bubun 
Published: January 2022

Abstract
2-Hydroxy-1,4-naphthaquinone, commonly known as lawsone, represents an extremely important biologically active naturally occurring compound. It can easily be isolated from Lawsonia inermis (henna) tree leaf extract. Last decade has seen tremendous applications of lawsone as a starting component for the preparation of various organic scaffolds. Many of these synthesized scaffolds showed a wide range of biological activities including potential activities towards several cancer cell lines. This review deals with diverse synthetic methods of lawsone derived scaffolds and their screening against different anti-cancer cell lines along with promising results.
Passive Proprioceptive Training Alters the Sensitivity of Muscle Spindles to Imposed Movements
Authors: Ackerley Rochelle , Samain-Aupic Léonard , Ribot-Ciscar Edith 
Published: January 2022

AbstractHumans rely on precise proprioceptive feedback from our muscles, which is important in both the acquisition and execution of movements, to perform daily activities. Somatosensory input from the body shapes motor learning through central processes, as demonstrated for tasks using the arm, under active (self-generated) and passive conditions. Presently, we investigated whether passive movement training of the ankle increased proprioceptive acuity (psychophysical experiment) and whether it changed the peripheral proprioceptive afferent signal (microneurography experiment). In the psychophysical experiment, the ankle of 32 healthy human participants was moved passively using pairs of ramp-and-hold movements in different directions. In a pretraining test, participants made judgements about the movement direction in a two-alternative forced choice paradigm. Participants then underwent passive movement training, but only half were cued for learning, where a reference position was signaled by a sound and the participant had to learn to recognize this position; they then completed a post-training test. In a paradigm using the same setup, nine healthy participants underwent microneurography recordings of Ia muscle afferents from the peroneal nerve, where all were cued during training. In the psychophysical experiment, proprioceptive acuity improved with training only in the cued group. In the microneurography experiment, we found that muscle afferent firing was modulated, via an increase in the dynamic index, after training. We suggest that changes in muscle afferent input from the periphery can contribute to and support central perceptual and motor learning, as shown under passive conditions using ankle movements, which may be exploited for movement rehabilitation.
Excitable Axonal Domains Adapt to Sensory Deprivation in the Olfactory System
Authors: George Nicholas M. , Gentile Polese Arianna , Merle Laetitia , Macklin Wendy B. , Restrepo Diego 
Published: January 2022

The axon initial segment (AIS), nodes of Ranvier, and the oligodendrocyte-derived myelin sheath have significant influence on the firing patterns of neurons and the faithful, coordinated transmission of action potentials (APs) to downstream brain regions. In the olfactory bulb (OB), olfactory discrimination tasks lead to adaptive changes in cell firing patterns, and the output signals must reliably travel large distances to other brain regions along highly myelinated tracts. Whether myelinated axons adapt to facilitate olfactory sensory processing is unknown. Here, we investigate the morphology and physiology of mitral cell (MC) axons in the olfactory system of adult male and female mice and show that unilateral sensory deprivation causes system-wide adaptations in axonal morphology and myelin thickness. MC spiking patterns and APs also adapted to sensory deprivation. Strikingly, myelination and MC physiology were altered on both the deprived and nondeprived sides, indicating system level adaptations to reduced sensory input. Our work demonstrates a previously unstudied mechanism of plasticity in the olfactory system.SIGNIFICANCE STATEMENTSuccessful transmission of information from the olfactory bulb (OB) to piriform cortex through the lateral olfactory tract (LOT) relies on synchronized arrival of action potentials (APs). The coincident arrival of APs is dependent on reliable generation of APs in the axon initial segment (AIS) and fast conduction mediated by axon myelination. Here, we studied changes in mitral cell (MC) firing and AIS structure as well as changes in myelination of the LOT on unilateral olfactory deprivation in the adult mouse. Strikingly, myelination and MC physiology were altered on both the deprived and nondeprived sides, indicating system level adaptations to reduced sensory input. Our work demonstrates a previously unstudied mechanism of plasticity in the olfactory system.
Gestión de riesgo para la prevención primaria de tuberculosis en una entidad administradora de planes de beneficios en salud en Colombia
Authors: Rojas Suárez Marlen Astrid , García Ubaque Juan Carlos 
Published: January 2022

Objetivo Diseñar y validar un modelo para la gestión del riesgo en salud, orientado a disminuir la incidencia de la tuberculosis en la población afiliada a las empresas administradoras de planes de beneficios colombianas (EAPB) desde la perspectiva de prevención primaria de la enfermedad. Métodos A partir de una reflexión inductiva, se diseñó un modelo de atención en tuberculosis orientado a coordinar acciones de gestión integral de riesgo en salud en el contexto de un modelo de aseguramiento fundamentado en la atención primaria en salud (APS). Se realizó una validación facial y de contenido del modelo con expertos temáticos en el programa de control de la tuberculosis de algunas EAPB y otros sectores. Resultados Se identificaron aspectos eje, fortalezas y oportunidades de mejora que se utilizaron como elementos centrales para el modelo, el cual se orienta a prevenir el desarrollo de la enfermedad, al tiempo que continúa promoviendo el seguimiento a los tratamientos y los procesos de rehabilitación. La revisión de expertos permitió validar y enriquecer el diseño planteado. Discusión La gestión del riesgo en salud es una responsabilidad asignada dentro del sistema de salud colombiano a las EAPB. El diseño del presente modelo aporta para que la gestión del riesgo se realice de manera organizada, definida y estandarizada, a fin de obtener mejores resultados en la prevención de la tuberculosis.
Letermovir profilaxis allogén vérképző-őssejt transzplantációban: egy hazai centrum gyakorlati tapasztalatai
Authors: Sinkó János , Körösmezey Gábor , Paksi Melinda , Gopcsa László , Reményi Péter 
Published: January 2022

Összefoglaló.
Bevezetés: A humán cytomegalovírus infekció direkt és indirekt
szövődményei napjainkban is veszélyeztetik az allogén őssejt-transzplantációval
kezelt betegeket. A széles körben alkalmazott preemptív stratégia mellett
előnyös lehet a kórokozó reaktivációjának megelőzése profilaktikusan adagolt
vírusellenes vegyülettel. A letermovir innovatív hatásmechanizmusú, szűk
spektrumú antivirális szer, mely allogén őssejt-transzplantáltak körében
végzett, placebo kontrollált klinikai vizsgálatban csökkentette a
cytomegalovírus infekciók gyakoriságát és javította a túlélést. A szerzők 23,
allogén őssejt-transzplantált beteg retrospektív módon gyűjtött adatait
ismertetik, akik a beavatkozás kapcsán letermovir profilaxisban részesültek. A
betegek több mint fele akut leukémiában szenvedett, harmaduk aktív betegséggel
került transzplantációra, kétharmaduk donora haploidentikus egyezést mutatott. A
letermovir adagolása során 2, azt követően további 3 személyben lépett fel
cytomegalovírus infekció. Szervi érintettséggel járó cytomegalovírus betegség
egyetlen esetben sem alakult ki. A megfigyelési időszak során 2 fő hunyt el,
cytomegalovírustól független okok miatt. Az alkalmazhatóságot korlátozó
mellékhatást nem észleltek. A letermovir a mindennapi klinikai gyakorlatban is
hatékonynak és biztonságosnak bizonyult az őssejt-transzplantáltak
cytomegalovírus fertőzésének megelőzésére.
Summary.
Introduction: Direct and indirect effects of cytomegalovirus
infection remain an ongoing threat to patients treated with allogeneic stem cell
transplantation. In addition to the widely used preemptive approach, prevention
of viral replication with a prophylactically administered antiviral drug seems
to be feasible. Letermovir, a narrow-spectrum antiviral compound with an
innovative mechanism of action, has been shown to decrease the incidence of
cytomegalovirus infection and to improve survival in a placebo-controlled
clinical trial recruiting allogeneic stem cell transplant patients. Authors
present retrospectively collected data from 23 patients receiving letermovir
prophylaxis as a part of their allogeneic stem cell transplantation procedure.
More than half of prophylaxed individuals had acute leukemia, a third of them
underwent transplantation with an active disease and two third of the cohort had
a haploidentical donor. During prophylaxis 2, subsequently further 3 patients
developed a cytomegalovirus infection. No organ-specific disease could be
detected. Through the observational period 2 patients have died due to causes
unrelated to cytomegalovirus. No side effect interfering with drug use could be
revealed. In this real-life case series letermovir has been shown to be
effective and safe for the prevention of cytomegalovirus infection in allogeneic
stem cell transplant patients.
SOCIAL DEIXIS ANALYSIS IN THE FINAL INTERVIEW WITH THE OBAMAS
Authors: Nuryusticia Erfina , Nurrachman Dian 
Published: January 2022

The final interview with Obama, as one of influential persons in the world, attracted many media to broadcast. His interview showed real-life interaction of a representative figure so that the way he used language is also representative. Specifically, this study aims at finding out the kinds of social deixis and to describe the function of social deixis in The Final Interview with the Obamas. The data are analyzed in a qualitative descriptive method to point out the phenomena of social deixis in the news as a part of daily life and since the collection of the data are mostly analyzed by using description and explanation form which focus on the characteristics, types, and the reason why the usage of social deixis is the main issues to be investigated. Based on the analysis of The Final Interview with The Obamas from the PeopleTV YouTube channel, it can be concluded that all types of social deixis according to Levinson’s theory are found in the object of research. There are relational which manifested by the speaker and referent, the speaker and addressee, the speaker and bystander, and the speaker and setting. There is also absolute social deixis which is manifested by the authorized speaker, and the authorized recipient absolute social deixis. In addition, the three functions of social deixis are also found in the utterances in The Final Interview with The Obamas. Those are the social status differentiation function, politeness function, and social identity function. Keywords: Social Deixis; Interview; Pragmatics
QUALITY AND MICROBIOLOGICAL SAFETY OF A DAILY MORTALITY COMPOST PRODUCED IN A VETERINARY FACULTY AT SÃO PAULO STATE
Authors: Villamizar Cancelado Sonia 
Published: January 2022

Introduction: Daily and outbursts mortality composting have been identified as one of the finest methods for final disposal of animal corpses, but the probable threat of pathogens transmission truly limits its use. Materials and Methods: In this study we evaluated the quality and microbiological biosafety of a compost produced in daily mortality experimental unit composting at the Universidade Estadual Paulista in the state of Sao Paulo, Brazil. Settled compost sample was evaluated in order to determine the presence and counting of coliforms and Salmonella sp. and the pathotypes of E. coli STEC, EPEC and EHEC using culture and molecular techniques. The occurrence of frequent soil borne phytopathogenic fungi was also estimated using selective and differential microbiological culture media. Results and Discussion: The occurrence of pathogenic E. coli, Salmonella sp and phytopathogenic fungi were negative. Coliforms level was 3.05 log10/g. Concussions: The results showed that daily mortality composting method is effective to reduce pathogenic microorganisms, however, in order to add the product on crops or plants such as vegetables that are for direct human consumption, additional tests must be performed to assess the presence of viral pathogens and endospores forming bacteria.
Creation of a collection of blood samples of patients with multiple myeloma
Authors: Gnennaya N. V. , Timofeeva S. V. , Sitkovskaya A. O. , Novikova I. A. , Lysenko I. B. , Kamaeva I. A. , Kit O. I. 
Published: January 2022

Aim. To create a collection of samples of blood components of patients with multiple myeloma for potential fundamental and applied biomedical research.Material and methods. The material was collected according to the developed algorithm, including the collection of clinical information, biological material, sample preparation, quality control and storage in the biobank of the National Medical Research Center of Oncology.Results. As of August 2021, the cryostorage of the National Medical Research Center of Oncology biobank contains a collection of 175 samples of blood serum, plasma and mononuclear cell fraction of patients with multiple myeloma. Samples were obtained from 32 patients of both sexes, the mean age of which was 59,5±1,65 years. To create an electronic catalog, personal, clinical and laboratory data about patients were collected, after which each sample was assigned its own unique identification number. Written informed consent was obtained from all patients for the storage of their biomaterial in a biobank with possible subsequent use for scientific purposes. Freezing of the obtained samples was carried out in accordance with low-temperature storage protocol. The electronic catalog contains a wide range of systematized clinical and laboratory information on samples.Conclusion. The collection of multiple myeloma samples is a unique resource for potential research on its pathophysiology, the development of diagnostic biomarkers, and the search for targeted agents.
Effects of Pharmacy Care Program on medication adherence in outpatients with stable coronary artery disease: a randomized controlled study
Authors: Fitilev S. B. , Vozzhaev A. V. , Klyuev D. A. , Shkrebniova I. I. , Shindryaeva N. N. , Saakova L. N. , Shkirando Yu. V. 
Published: January 2022

Aim.To assess the effects of the Pharmacy Care Program on medication adherence in outpatients with stable coronary artery disease (SCAD).Material and methods. An open randomized controlled study was conducted in primary care clinic over the period of 2019-2020. All subjects (n=126) were randomized at visit 1 into the multifaceted intervention group (n=63) or control group (n=63) and invited 12 months after to visit 2. Patients of intervention group were included into the Pharmacy Care Program, which consisted of the following components: pharmacist-led counseling, provision of education materials and 7-day pillbox, weekly SMS-reminders. Medication adherence was measured initially and at the end of the study period by means of eight-item Morisky Medication Adherence Scale (MMAS-8) and Self-Efficacy for Appropriate Medication Use Scale (SEAMS).Results.The implementation of the Pharmacy Care Program improved medication adherence in SCAD outpatients with MMAS-8 median score of 7,0-8,0 (p<0,001) and SEAMS median score of 35,0-36,0 (p=0,017). In the control group, no changes (p=0,123) in MMAS-8 score were revealed, while SEAMS score decreased from 35,0 down to 34,5 (p=0,003). The reduction in systolic blood pressure (p=0,049) and risk of urgent hospital admission (OR=0,28; 95% CI, 0,08-0,99; p=0,041) was registered in the intervention group in contrast to the control group over the 12-month period.Conclusion.The multicomponent intervention within the Pharmacy Care Program contributed to an increase in the adherence to pharmacotherapy of outpatients with stable CAD.
Coagulation status in patients with pulmonary embolism receiving long-term anticoagulant therapy
Authors: Shmidt E. A. , Berns S. A. , Penskaya T. Yu. , Zhidkova I. I. , Gruzdeva O. V. , Barbarash O. L. 
Published: January 2022

Aim. To study the blood coagulation status by various laboratory methods in patients after pulmonary embolism (PE) receiving long-term anticoagulant therapy.Material and methods. The blood of 23 patients with pulmonary embolism, who received long-term anticoagulant therapy, was studied. The study of coagulation profile, D-dimer, thrombodynamics, thromboelastography and thrombin generation test were carried out.Results. The thrombin generation test shows a significant increase in the time of its formation, while the maximum amount of thrombin formed is half that of the reference values. There is a slightly increased median fibrin clot growth rate in the thrombodynamics test — 30,4 gm/min with a normal coagulation rate of 20-29 gm/min. The result of thromboelastography also reflects the blood hypocoagulation, in terms of R, Angle a and CI.Conclusion. Integral methods for assessing the thrombotic readiness in combination with a routine coagulation panel demonstrate a complete picture of blood coagulation potential in patients after pulmonary embolism requiring long-term anticoagulant therapy.
Associations of circulating biomarkers with the presence and severity of coronary, carotid and femoral arterial atherosclerosis
Authors: Metelskaya V. A. , Zhatkina M. V. , Gavrilova N. E. , Yarovaya E. B. , Bogdanova N. L. , Kutsenko V. A. , Rudenko B. A. , Drapkina O. M. 
Published: January 2022

Aim. To identify and characterize the associations of the presence and severity of atherosclerosis of various localization with the blood level of biochemical parameters, as well as to assess the potential of their use as markers of metabolic disorders with increased atherogenic potential.Material and methods. The study included 216 patients (men, 53%) aged 24-87 years (mean age, 61,5±10,73 years). All patients underwent coronary angiography, carotid (CA) and femoral arterial (FA) duplex ultrasound to assess the presence and severity of atherosclerosis. In blood serum/plasma, biochemical parameters were analyzed using standard methods.Results. Based on the analysis of circulating biomarker profile, diagnostic complexes have been established that allow assessing atherosclerosis of different localization. According to the data obtained, the determinants of coronary and CA atherosclerosis are endothelial dysfunction (concentration of nitric oxide metabolites <36,0 μmol/L) and an increased level of creatinine (≥73,0 μmol/L). The specific markers associated with severe atherosclerosis of coronary and FAs (but not CA) were low high-density lipoprotein cholesterol (≤1,0/1,2 μmol/L for male/ female, respectively) and an increased C-reactive protein level (≥1,0 mg/l). Severe peripheral atherosclerosis (CA and FA involvement) was associated with hyperglycemia (glucose ≥6,1 μmol/L), while severe FA atherosclerosis — with hyperinsulinemia (insulin ≥14,0 μU/ml).Conclusion. The analysis of associations of circulating biochemical parameters with atherosclerosis localization and severity revealed a number of metabolic markers associated with the increased atherogenic potential. It is possible to distinguish both universal parameters that are associated with atherosclerosis, regardless of its localization and/or severity, and specific biomarkers that characterize either the localization or the severity of atherosclerosis, or both.
Optimization of RNA storage in a biobank, as well as methods for manual and automated isolation of RNA from whole blood and leukocyte fraction
Authors: Romanyuk S. A. , Popov O. S. , Sushentseva N. N. , Apalko S. V. , Polkovnikova I. A. , Shcherbak S. G. 
Published: January 2022

Aim. To optimize the technique for the isolation and storage of ribonucleic acid (RNA) from whole blood and leukocyte fraction.Materials and methods. Comparison of isolation quality was carried out for RNA samples obtained from 228 leukocyte samples and 198 whole blood samples. Isolation was performed from fresh and frozen samples using ExtractRNA™ reagent and a MagNA Pure Compact automated system. Various methods of removing erythrocytes (centrifugation and treatment with hemolytic agents from two manufacturers) were tested, as well as freezing with and without preservatives for subsequent RNA isolation.Results. Twenty-one combinations of conditions were tested. The highest quality RNA was isolated by manual extraction using the ExtractRNA™ reagent from a fresh leukocyte fraction, purified by the Amplisens hemolytic agent (successful extraction — 94%, median RIN=8,4); frozen in IntactRNA™, purified by leukocyte fraction centrifugation (successful extraction — 100%, median RIN=8); frozen in ExtractRNA™, purified by leukocyte fraction centrifugation (successful extraction — 100%, median RIN=9,3).Conclusion. RNA can be isolated from frozen blood fractions, which is not inferior in quality to that isolated from fresh samples. Thus, it is not necessary to isolate RNA immediately after the receipt of biological material.