bluuebunny/crossref_metadata_2025_split huggingface dataset:
24-HOUR AMBULTORY BLOOD PRESSURE MEASUREMENT USING A NOVEL NON-INVASIVE, CUFF-LESS, WIRELESS DEVICE
Authors: Eisenkraft Arik 
Published: June 2022

Objective:
Ambulatory blood pressure monitoring (ABPM) using cuff-based devices is used for the diagnosis and treatment of hypertension. Technical limitations, low compliance, and complex procedures limit their use. The aim of the present study was to test the accuracy of a new photoplethysmography (PPG)-based, wearable device (Wrist-monitor) as compared to the standard cuff-based ABPM device.

Design and method:
24H ABPM was performed in parallel for both devices on volunteers aged 18–65 years while documenting their daily activities. The level of comfort and activity disturbance of both devices were recorded. Linear regression and Bland-Altman were used to evaluate the agreement between devices. Receiver Operating Characteristic (ROC) curve analysis was used to classify hypertension based on the average Wrist-monitor measurements as compared to a cuff-based ABPM device.

Results:
The study included 28 subjects (18 men) mean age of 41.5 ± 16.2 years. The Bland-Altman analysis resulted in a 24H bias of -1.1 mmHg for both diastolic blood pressure (DBP) and systolic blood pressure (SBP). Mean daytime bias was -1.9 mmHg for DBP and SBP, while nighttime bias was smaller (0.7 and 0.4 mmHg for DBP and SBP respectively). ROC curve analysis yielded a mean area under the curve (AUC) of 1 for SBP and 24H BP measurements. AUCs of 0.994 and 0.955 were found for the daytime DBP and night DBP, respectively. 24H ABPM with the Wrist-monitor caused significantly less inconvenience compared to the cuff-based device (p < 0.001).

Conclusions:
The cuff-less device provides comparable measurements to those obtained with the currently used cuff-based ABPM device, with significantly less inconvenience to the subject.
BLOOD PRESSURE AWARENESS AND CONTROL IN SWISS PHARMACIES DURING MMM17–18 CAMPAIGNS
Authors: Damianaki Katerina , Menetre Gerald , Burnier Michel , Wuerzner Gregoire 
Published: June 2022

Objective:
May Measurement Month (MMM) is a worldwide hypertension awareness campaign. The objective was to determine the usefulness of pharmacies in the detection of high blood pressure (BP) using the ESH 2018 and the ESH 2021 proposed threshold for diagnosis of hypertension in pharmacies.

Design and method:
Forty-one pharmacies in the Canton of Vaud (Switzerland) evaluated the participants during MMM17 campaign and 271 pharmacies in Switzerland evaluated the participants during MMM18 campaign. After obtaining inform consent form, BP and a short questionnaire focusing on basic demographic and clinical information were recorded. ESH 2018 threshold of 140/90mmHg and ESH 2021 pharmacy-threshold of 135/85mmHg were used for our analysis. Descriptive statistics and t-test were used appropriately.

Results:
2060 participants had their BP measured in pharmacies. Mean age was 48.5 ± 19 years and almost ¾ of the participants were women (71.6% p < 0.001). BP measurement in pharmacies was associated with a first measure effect of 2.8 ± 0.17 mmHg on SBP and 0.9 ± 0.13 mmHg on DBP.
689 (33.5%) and 840 (40.8%) participants presented a high BP based on ESH 2018 threshold and ESH 2021 pharmacy-based threshold respectively. In treated participants, 56.9% had average BP lower than 140/90mmHg.

Conclusions:
Mainly female participants had their BP measured in pharmacies. Screening for high BP in pharmacies is feasible and recruits mainly female participants. Based on pharmacy thresholds, the prevalence of hypertension was higher than expected for Switzerland. A first measure effect was also present in pharmacies, suggesting that three measures should be performed at pharmacies and the first one should be discarded from the mean BP calculation.
REPRODUCIBILITY OF WHITE COAT HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Antza Christina , Farmakis Ioannis , Doundoulakis Ioannis , Akrivos Evangelos , Stalikas Nikolaos , Zafeiropoulos Stefanos , Kostopoulos Georgios , Stabouli Stella , Giannakoula George , Kotsis Vasilios 
Published: June 2022

Objective:
The aim of this study was to investigate the reproducibility of white coat hypertension (WCH) either with ambulatory blood pressure monitoring (ABPM) or home blood pressure monitoring (HBPM).

Design and method:
PubMed, Cochrane Library and Web of Science were searched to identify studies with paired baseline office BP and ABPM or HBPM measurements at two timepoints. The outcome of the analysis was the individual phenotype reproducibility between the baseline and follow-up timepoints. The used effect measure was Cohen’s kappa coefficient.

Results:
We found 15 studies eligible for the meta-analysis (5729 patients). The reproducibility of WCH with both methods was low, indicating slight agreement. Kappa reliability test was slightly better with ABPM (k: 0.27, 95%CI: 0.12–0.41) than with HBPM (k: 0.18, 95%CI: 0.08–0.27).

Conclusions:
This systematic review and meta-analysis show a slight reproducibility of WCH assessed either through HBPM or ABPM. Considering that poor reproducibility may be a result of office BP measurements, an ABPM/HBPMnbased strategy should be established for the evaluation and treatment of patients with WCH.
PSYCHOLOGICAL AND QUALITY OF LIFE SCALE SCORES CORRELATED WITH THE WINTER INCREASE OF AMBULATORY BLOOD PRESSURE IN PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Andreeva Galiya , Deev Alexander , Gorbunov Vladimir 
Published: June 2022

Objective:
The aim of study was to define correlations between winter blood pressure (BP) increase and psychological, quality of life (QL), demographic factors in patients with arterial hypertension (AH) (Moscow region).

Design and method:
We assessed 980 ambulatory blood pressure monitoring (ABPM) data AH patients without serious concomitant diseases. ABPM monitor (Spacelabs 90207) was applied after the washout period (at 8.30–12.00 am). We defined daytime period as 8.00–22.00, nighttime – 0.00–6.00, evening – 21.00–23.00, morning – 6.00–8.00 and workplace period as 11.00–19.00. After ABPM session patients completed the QL questionnaire. (J.Siegrist et all.). The systolic and diastolic (SBP and DBP) winter increase BP was assessed for: daytime (BPd), nighttime (BPn), evening (BPe), morning (BPm), workplace (BPw) and 24-hours period (BP24). We used General Linear Model (GLM) Procedure for statistical analysis adjustment for age, sex and duration of AH and Fisher’s (F) test.

Results:
We have identified the following QL factors that were significantly associated with the SBP winter increase: 1) VI scale scores of QL questionnaire (reflects the level of social support of family, friends, colleagues) with SBPn (F = -6,62 p < 0,01), SBPd (F = -11,12, p < 0,001), SBPw (F = -9,33, p < 0,003), SBPm (F = -10,59 p < 0,001), SBPe (F = -5,4, p < 0,02); 2) IV scale scores (negative psychological well-being) with SBPw (F = 9,33, p < 0,003). The following factors were significantly associated with the DBP winter increase: 1) VI scale scores with DBPd (F = 4,06, p < 0,04), SBPm (F = 4,29 p < 0,004).
Thus, such QL components as the social support from family, friends, colleagues, (VI scale scores) and the negative emotions (IV scale scores) have been associated with the winter BP increase (negative and positive correlation respectively).

Conclusions:
The new preventive strategy for reducing winter BP may include the increase communication with family and friends and to reduce the impact of negative emotions in the workplace in Moscow region patients with AH.
SHORT-TERM BLOOD PRESSURE VARIBILITY AND LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Vulin Aleksandra , Sucur Nikola , Delic Zorica , Poljak Jelena Pavic , Ljubotina Andrea , Todic Vanja Drljevic , Popov Iva 
Published: June 2022

Objective:
To determine the association of short-term blood pressure variability (BPV) with left ventricular diastolic dysfunction (LVDDF) in patients with arterial hypertension.

Design and method:
A retrospective analysis of data from outpatient department of the Institute of cardiovascular diseases of Vojvodina during 2020 was conducted. NYHA I patients, with treated arterial hypertension and preserved left ventricular ejection fraction, without diagnosed cardiovascular disease and diabetes mellitus were included. Indices of short-term BPV standard deviation (SD) and coefficient of variation (CV), and average real variability (ARV) of systolic blood pressure (SBP) and diastolic blood pressure (DBP) during 24 h, daytime and nighttime were calculated from 24 h ambulatory blood pressure monitoring. LVDDF was determined according to the 2016 recommendations of the American Society of Echocardiography and the European Association of Cardiovascular Imaging.

Results:
The study included 108 patients, mean age 60.74 ± 13.20 years, 55 (50.9%) were male. 71 (65.7%) patients had preserved diastolic function, 27 (25%) had stage I DDF, 7 (6.5%) stage II DDF, and stage III DDF 2 (2.8%). There were statistically significant higher daytime diastolic BP AVR with higher LVDDF stages (p = 0.014). Daytime diastolic BP AVR was the independent predictor of LVDDF presence (OR 1.32 95% CI (1.074–1.623); p = 0.008), independent predictor of e’septal velocity < 0.07m/s or e’lateral velocity< 0.1m/s (OR 1.29 95% CI (1.04–1.60); p = 0.020), and the only predictor of TR velocity > 2.8m/s (OR 1.47 95% CI (1.10–1.96); p = 0.009). No examined indices were ssociated with LA Volume index> 34 ml/m2 and E/e’> 14.

Conclusions:
In the examined group of patients with arterial hypertension, daytime diastolic BP AVR was the independent predictor of left ventricular DDF presence, which may suggest that daytime diastolic BP variability could be important for development of heart failure with preserved left ventricular ejection fraction.
SEX DIFFERENCES IN AMBULATORY BLOOD PRESSURE TRAJECTORIES AND BLOOD PRESSURE VARIABILITY IN HEMODIALYSIS PATIENTS
Authors: Theodorakopoulou Marieta , Karagiannidis Artemios , Alexandrou Maria-Eleni , Pella Eva , Karpetas Antonios , Baksiova Afroditi , Tsouchnikas Ioannis , Papagianni Aikaterini , Sarafidis Pantelis 
Published: June 2022

Objective:
Ambulatory blood pressure (BP) control is worse in men than in women with chronic kidney disease (CKD) and this may partially explain the faster CKD progression in men. The aim of this study is to investigate possible sex-differences in ambulatory BP levels, BP trajectories, and BP variability (BPV) in hemodialysis patients.

Design and method:
129 male and 91 female hemodialysis patients that underwent 48-h ABPM with Mobil-O-Graph-NG were included in this analysis. Ambulatory BP levels over the 2-day interdialytic interval (including two daytime and two nighttime periods) were recorded. We calculated the standard deviation (SD), weighted SD (wSD), coefficient of variation (CV), and average real variability (ARV) of BP with validated formulas.

Results:
Age, dialysis vintage, antihypertensive treatment and history of major comorbidities did not differ between men and women. Pre-dialysis SBP levels did not differ between men and women (145.1 ± 22.7 vs 145.9 ± 25.7mmHg, p = 0.808), but DBP was marginally higher in men (87.6 ± 14.0 vs 84.0 ± 13.7mmHg, p = 0.055). 48-h SBP/DBP (137.2 ± 17.4/81.9 ± 12.1mmHg vs 132.2 ± 19.2/75.9 ± 11.7mmHg, p = 0.045/ < 0.001) as well as DBP during the 1st and SBP/DBP during the 2nd 24-h period were significantly higher in men than in women. Similarly, daytime SBP/DBP was significantly higher in men (138.3 ± 17.5/83.2 ± 12.3mmHg vs 131.9 ± 19.4/76.4 ± 11.5mmHg. p = 0.011/< 0.001). No significant between-group differences were detected for nighttime SBP. All SBP variability indices were similar between men and women; DBP-SD, DBP-wSD and DBP-ARV were higher in men (44-h DBP-ARV 9.4 ± 1.8 vs 8.6 ± 1.9, p = 0.002). No significant differences were revealed in the dipping pattern between men and women.

Conclusions:
Ambulatory BP levels and trajectories, as well as DBP variability indices are higher in men than women hemodialysis patients. This worse ambulatory BP profile in male compared to female patients may impact on the incidence of cardiovascular events.
IDENTIFICATION OF HYPERTENSIVE PATIENTS WITH INCREASED BLOOD PRESSURE VARIABILITY USING DIFFERENT MEASUREMENT METHODS BEFORE AND AFTER TREATMENT: THE REVERENT TRIAL
Authors: Kollias Anastasios , Kyriakoulis Konstantinos , Bilo Grzegorz , Soranna Davide , Liu Chang-Yuan , Pengo Martino , Zambon Antonella , Zhang Wei , Wang Jiguang , Stergiou George , Parati Gianfranco 
Published: June 2022

Objective:
Blood pressure (BP) variability (BPV) can be assessed with office (OBP), home (HBP), and ambulatory BP (ABP) measurements. In this analysis, BPV indices assessed using all the three methods were compared before and 10 weeks after administering antihypertensive drug treatment.

Design and method:
Untreated hypertensives (or treated after washout period) with elevated BPV (systolic HBP standard deviation [SD] > 7 mmHg and/or systolic daytime ABP SD > 12 mmHg), were nalysedd to ramipril 10 mg or nifedipine gastrointestinal therapeutic system (GITS) 30 mg once daily, in the context of a multicenter 10-week, prospective, nalysedd, open-label, blinded-end point study. BPV was assessed using SD and coefficient of variation (CV) [weighted SD (wSD) and weighted CV (wCV) for 24h-ABP variability) of individual measurements.

Results:
Data from 146 participants from three research centers (Athens, Milan, Shanghai) were nalysed (mean age 53 ± 10 [SD] years, males 60%, baseline systolic OBP, HBP and 24h-ABP 143 ± 10, 138 ± 10, and 143 ± 10 mmHg, respectively). All BPV indices (except for diastolic OBP) presented significant correlations in terms of pre- vs post- treatment, with ABP indices (especially diastolic) achieving the strongest correlations (Table). Moreover, out-of-office BPV indices (especially ABP) presented fair to moderate agreement in detecting participants with high BPV (top quartile of respective distribution) pre- vs post- treatment.

Conclusions:
Untreated hypertensives with high out-of-office BPV retain this classification even after BP lowering therapy, which suggests that BPV is an intrinsic feature of the individuals’ BP.
BLOOD PRESSURE VARIABILITY AT REST AND DURING AEROBIC EXERCISES IN WOMEN WITH ISCHEMIC CARDIAC DISESES
Authors: Siegelova Jarmila , Havelkova Alena , Dusek Jiri , Dunklerova Leona , Pohanka Michal , Dobsak Petr , Cornelissen Germaine 
Published: June 2022

Objective:
High visit-to-visit blood pressure (BP) variability increases the risk of cardiovascular disease in hypertension. In some earlier studies there was the hypothesis that exact same doses of exercise evokes the same response of BP and heart rate (HR).
The aim of the study was to compare auscultatory measurements of SBP and DBP during cardiac aerobic exercise training twice a week, lasting three weeks in women with ischemic heart disease.

Design and method:
We examined 12 women with ischemic heart diseases, the age 60 ± 8.9 years, height 166 ± 6.7 cm, weight 78 ± 11.7 kg, ejection fraction was 46 ± 6 %. The cardiac patients were under therapy of betablockers. ACE inhibitors and statins. The intensity of aerobic training was determined individually according spiroergometric examination of the first ventilatory anaerobic threshold. BP measurements were provided using auscultatory measurement of BP at resting values, after warm-up period (10 minutes), at the peak of aerobic training period (40 minutes), at the cool-down period (10 minutes) twice a week, the training lasted 3 weeks.

Results:
Resting average values in the whole group of SBP were 129.0 ± 11.7 mmHg, of DBP 77.7 ± 8.5 mmHg, HR 71.7 ± 7.1 beat per minute.
After warm-up period average values in the whole group of SBP were 126.7 ± 10.4 mmHg, of DBP 76.5 ± 7.0 mmHg, HR 84.4 ± 9.0 beat per minute.
At aerobic peak - average values in the whole group of SBP were 135.1 ± 15.4 mmHg, of DBP 86.7 ± 10.9 mmHg, HR 86.6 ± 10.0 beat per minute.
After cool-down period - average values in the whole group of SBP were 135.6 ± 13.3 mmHg, of DBP 87.8 ± 9.8 mmHg, HR 85.3 ± 11.6 beat per minute.
Our results showed that SBP and DBP varies in resting values before exercise, after warm-up period, at the peak of aerobic exercise on the individual aerobic threshold value of load and after cool-down period from twenty mmHg to less mmHg.

Conclusions:
Aerobic exercise did not influence the values of this BP variability. Variability of the HR is also present at period of aerobic exercise training.
STUDY OF NYCTHEMERAL VARIATIONS IN BLOOD PRESSURE IN PATIENTS WITH NON-ARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY
Authors: Gaillard-Groléas Claire , Chiquet Christophe , Aptel Florent , Pepin Jean-Louis , Pollet-Villard Frederic , Ormezzano Olivier 
Published: June 2022

Objective:
Non-arteritic anterior ischemic optic neuropathy (NAAION) is the most common acute pathology of the optic nerve in patients over 50 years of age and loss of vision is irreversible in the vast majority of cases. The role of nocturnal arterial hypotension in the occurrence of NAAION remains a topic of debate. Indeed, studies on this subject are rare and the results contradictory. In this study, we ubject the nychthemeral variations in blood pressure (BP) in a large cohort of patients with acute NAAION to determine the presence and extent of nocturnal arterial hypotension in this population, and thus determine whether nocturnal arterial hypotension could be involved in the pathophysiology of NAAION

Design and method:
BP was recorded for 24 h (ambulatory blood pressure monitoring, ABPM) in 65 patients with acute NAAION. Three definitions of nighttime periods were used: definition 1, 1 a.m.–6 a.m.; definition 2, 10 p.m.–7 a.m.; and definition 3, 10 p.m.–8 a.m. For each of these definitions, patients were classified according to the value of nocturnal reduction in BP into dippers (10–20%), mild dippers (0–10%), reverse dippers (< 0%), and extreme dippers (> 20%).

Results:
The proportions of dippers, mild dippers, reverse dippers, and extreme dippers varied significantly depending on the definition chosen. We found the highest number of patients with extreme dipping (23%) when using the strictest definition of nighttime period (definition 1, 1 a.m.–6 a.m.), as compared with 6.2% and 1.5% for the other definitions, respectively. Overall, 13 of 33 patients without known systemic hypertension (39%) were diagnosed with hypertension (systolic and/or diastolic hypertension) after ABPM. No risk factor for NAAION was associated with the extreme-dipping profile. Finally, the prevalence of systemic hypertension was high (69%).

Conclusions:
In our population of patients who had an episode of NAAION, the proportion of extreme dippers was higher than that usually found in the literature. The definition of the nighttime period used in this study had an impact on the proportion of extreme dippers and might probably explain the contradictory results from the few studies on this ubject.
ORTHOSTATIC HYPOTENSION AND MORTALITY RISK IN GERIATRIC OUTPATIENTS: THE IMPACT OF DURATION AND MAGNITUDE OF THE BLOOD PRESSURE DROP
Authors: Wiersinga Julia H. , Trappenburg Marijke C. , Rhodius-Meester Hanneke F.M. , Peters Mike J.L. , Muller Majon 
Published: June 2022

Objective:
Orthostatic hypotension (OH) is a common condition associated with an increased mortality risk. This study investigates this association specifically in geriatric outpatients and additionally ocuses on the duration and magnitude of OH.

Design and method:
In this observational prospective cohort study with geriatric outpatients from the Amsterdam Ageing cohort, we differentiated OH in Early OH (EOH) and delayed/prolonged OH (DPOH). The magnitude of drop in both systolic and diastolic blood pressure (BP) after either 1 or 3 minutes was quantified. Mortality data was obtained from the Dutch municipal register. Cox proportional hazard models were used to determine the association between OH and mortality, adjusted for sex and age (model 1), additionally adjusted for OH-inducing drugs and SBP (model 2) and the presence of cardiovascular disease and diabetes (model 3). Stratified analyses in patients with geriatric deficits were performed.

Results:
We included 1240 patients (mean age 79.4 ± 6.9years, 52.6% females). Prevalence of OH was 443 (34.9%); 148 (11.9%) patients had EOH and 285 (23.0%) DPOH. DPOH was associated with a higher mortality risk (HR,95%CI: 1.69(1.28–2.22)) whereas EOH was not associated with mortality risk. This association did not differ in patients with geriatric deficits. Furthermore, the magnitude of drop in both systolic and diastolic BP was associated with a higher mortality risk (see figure for results of SBP).

Conclusions:
The presence of DPOH and the magnitude of both systolic and diastolic OH are related to an increased mortality risk in geriatric outpatients. Whether the duration of OH and magnitude of the drop in blood pressure is causally related to mortality risk or whether it is a sign of decreased resilience remains to be elucidated.
HYPERTENSION FOLLOWING LIVING KIDNEY-DONATION: BETTER SAFE THAN SORRY. A SINGLE-CENTER STUDY
Authors: Mojaat Malek , Ben Salah Manel , Salem Mariem Ben , Handous Insaf , Hamouda Mouna , Letaief Ahmed , Aloui Sabra , Skhiri Habib 
Published: June 2022

Objective:
Evaluate the incidence of hypertension among living kidney-donors.

Design and method:
This is a retrospective, mono-centric and analytical study. Blood pressure was categorized as per the ACC/AHA hypertension guidelines 2021. Herein, we report the results among 40 living kidney-donors.

Results:
The study included 40 living kidney donors. The median age was 42 years [34 – 53]s. 75% were female. 62,5% were married. 80% of donors were related to the recipient. Parents and siblings accounted for 37,5 % and 35% respectively. 20% were spouses. 3 donors had a family history of CKD. 4 and 6 donors had a family history of hypertension and diabetes respectively. Neither diabetes nor CKD was found among donors’ personal history. One donor had a history of hypertension that was well-controlled on monotherapy. Median follow-up was 9 years [6 - 12] with a total period of follow-up ranging from 3 to 32 years. Median systolic and diastolic blood pressures at baseline (SBP, DBP) were 112,5 and 70 mmHg respectively. During follow-up, we noticed two peaks for the median SBP at six months and three years after nephrectomy reaching a maximal value of 120 mmHg and subsequently decreasing. The comparison with the baseline value did not show a statistically significant difference except at three years (median SBP before nephrectomy:112,5 mmHg, median SBP at three years after nephrectomy:120 mmHg, p = 0,03). The median DBP was relatively stable at 70 mmHg during follow-up. However, the comparison with the baseline value has shown a statistically significant elevation compared to baseline starting at two years (p = 0,002) and remained thereafter. After five years of follow-up, 12.5% and 7.5% of our patients developed stage one and two hypertension respectively. Non-pharmacologic management was enough for stage 1 hypertensive kidney donors but stage 2 patients required pharmacologic agents. Neither cardiovascular complications nor death were encountered during the study period.

Conclusions:
Our results showed that kidney donation is relatively safe unless a meticulous screening prior to nephrectomy is performed. Regular follow-up allows an early diagnosis of hypertension and prompt initiation of treatment, therefore avoiding severe complications