bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Low-power 2D Active Pixel Sensor Matrix with Spectral Uniformity, High Dynamic Range, Fast Reset, and De-noising Capabilities
Authors: Dodda Akhil , Jayachandran Darsith , Pannone Andrew , Trainor Nicholas , Stepanoff Sergei , Steves Megan , Radhakrishnan Shiva Subbulakshmi , Bachu Saiphaneendra , Ordonez Claudio , Shallenberger Jeffrey , Redwing Joan , Knappenberger Kenneth , Wolfe Douglas , Das Saptarshi 
Published: June 2022

Abstract
Development of low-power and smart vision sensors is critical for many emerging applications including the acceleration of edge intelligence. In this article, we introduce an active pixel sensor (APS) technology with in-sensor compute capability based on atomically thin two-dimensional (2D) semiconducting material such as monolayer MoS2. The presented 2D APS uses only one programmable phototransistor (1T cell), which significantly reduces the area overhead allowing one to fit 900 pixels in ~0.09 cm2. Phototransistors in the array exploit gate tunable persistent photoconductivity to exhibit high responsivity (~3.6×107 A/W), high specific detectivity (~5.6×1013 Jones), spectral uniformity, and high dynamic range (~80 dB) and electrical programmability to achieve fast reset (~ 100 µs) and in-sensor de-noising capabilities. Commonly encountered problems in the field of 2D material based vision sensors are also resolved by showing near-ideal yield and low device-to-device variation in photoresponse owing to high quality growth, damage-free transfer, and relatively clean fabrication process flow. Remarkably, the energy expenditure by 2D APS was found to be miniscule and in the range of hundreds of femto Joules per pixel. We believe, our low-power 2D APS technology with in-sensor image processing capabilities can be transformative for many edge applications.
Male Gender, Smoking, Younger Age, and Preoperative Pain Found to Increase Postoperative Opioid Requirements in 592 Elective Colorectal Resections
Authors: Karlsdottir Bergljot R. , Zhou Peige P. , Wahba Joyce , Mott Sarah L. , Goffredo Paolo , Hrabe Jennifer , Hassan Imran , Kapadia Muneera R. , Gribovskaja-Rupp Irena 
Published: June 2022

Abstract
Purpose
With increased awareness of the opioid epidemic, understanding contributing factors to postoperative opioid use is important. The purpose of this study was to evaluate patient and perioperative factors that contribute to postoperative opioid use after colorectal resections and their relation to pre-existing pain conditions and psychiatric diagnoses.
Methods
A retrospective review was conducted identifying adult patients who underwent elective colorectal resection at a single tertiary center between 2015 and 2018. Patient demographics, preoperative factors, surgical approach, and perioperative pain management were evaluated to determine standard conversion morphine milligram equivalents required for postoperative days 0 to 3 and total hospital stay.
Results
Five hundred and ninety-two patients: 46% male, median age 58 years undergoing colorectal resections for indications including cancer, inflammatory bowel disease, and diverticulitis were identified. Less opioid use was found to be associated with female gender (β = -42), patients who received perioperative lidocaine infusion (β = -30), and older adults (equivalents/year) (β = -4, all p < 0.01). Preoperative opioid use, preoperative abdominal pain, epidural use and smoking were all independently associated with increased postoperative opioid requirements.
Conclusions
In this study of patients undergoing elective colorectal resection, factors that were associated with higher perioperative opioid use included male gender, smoking, younger age, preoperative opioid use, preoperative abdominal pain, and epidural use. Perioperative administration of lidocaine was associated with decreased opioid requirements. Understanding risk factors and stratifying postoperative pain regimens may aid in improved pain control and decrease long-term dependency.
Analysis of viral integration reveals new insights of oncogenic mechanism in HBV infected- intrahepatic cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma
Authors: Zhao Linghao , Wang Yuyouye , Tian Tao , Rao Xinjie , Dong Wei , Zhang Jinmin , Yang Yuan , Tao Qifei , Peng Fang , Shen Chenhang , Wang Songbo , Liu Hui , Zeng Xi , Zhou Weiping 
Published: June 2022

Abstract
Background:Integration of HBV DNA into the human genome could progressively contributes to hepatocarcinogenesis. Both Intrahepatic cholangiocarcinoma (ICC) and Combined hepatocellular-cholangiocarcinoma (CHC) are known to be associated with HBV infection. However, the integration of HBV and mechanism of HBV-induced carcinogenesis in ICC and CHC remains unclear.Methods:41 patients with ICC and 20 patients with CHC were recruited in the study. We conducted HIVID analysis on these 61 samples to identify HBV integration sites in both the tumor tissues and adjacent non-tumor liver tissues. To further explore the effect of HBV integration on gene expression, we selected paired tumors and adjacent non-tumor liver tissues from 3 ICC and 4 CHC patients for RNA-seq and WGS.Results:We detected 493 HBV integration sites in ICC patients, of which 417 were from tumor samples, 76 were from non-tumor samples. And 246 HBV integration sites were detected in CHC patients, of which 156 were located in the genome of tumor samples and 90 were in non-tumor samples. Recurrent HBV integration events were detected in ICC including TERT, ZMAT4, MET, ANKFN1, PLXNB2, and in CHC like TERT, ALKBH5. Together with our established data of HBV-infected hepatocellular carcinoma, we found HBV preferentially integrates into the specific regions which may affect the gene expression and regulation in cells and induce carcinogenesis. We further performed genomic and transcriptomic sequencing of three ICC and four CHC patients and found that HBV fragments could integrate near some important oncogene like TERT, causing large-scale genome variations on nearby genomic sequences, and at the same time changing the expression level of the oncogene genes.Conclusion:Comparative analysis demonstrates numerous newly discovered mutational events in ICC and CHC resulting from HBV insertions in the host genome. Our study provides an in-depth biological and clinical insights into HBV-induced ICC and CHC.
First record of monogeneans from Schilbe intermedius in South Africa
Authors: Smit Willem J. , Matla Matsoele M. , Luus-Powell Wilmien J. 
Published: June 2022

Abstract
The present study deals with the survey of monogeneans from Schilbe intermedius Rüppell, 1832 (silver catfish). Surveys were carried out at six localities in the northern region of South Africa where fish were collected and examined for monogenean gill parasites. There are presently no records of monogeneans from this fish species from South Africa. Fourteen monogenean species of Schilbetrema Paperna and Thurston, 1968 and two species of Schilbetrematoides Kritsky and Kulo, 1992 have been recorded from African schilbeids. Three species of the Schilbetrema were recorded during this study with variation in infestation: Schilbetrema quadricornis Paperna and Thurston, 1968 from all localities; Schilbetrema acornis Paperna and Thurston, 1968 from four localities; Schilbetrema undinula Kritsky and Kulo, 1992 recorded from one locality.
Comparison of the Protective Efficacy of Intratympanic Oxytocin and Dexamethasone in Cisplatin-induced Ototoxicity
Authors: Taş Burak Mustafa , Özel Gökçe , Azman Musa , Karaer Işıl Çakmak , Kılıç Rahmi 
Published: June 2022

Abstract
Purpose: In this study, we aimed to investigate the efficacy of intratympanic resveratrol and intratympanic dexamethasone treatment in cisplatin-induced ototoxicity. We also compared intratympanic atosiban (oxytocin antagonist) and oxytocin in cisplatin ototoxicity. Methods: In this study, 30 rats (60 ears) were used by separating into 5 groups. Cisplatin was administered intraperitoneally to the first group (n=6). On the second group (n=6), oxytocin were administered intratympanically. On the third group (n=6), dexamethasone were administered intratympanically. On the fourth group (n=6), atosiban were administered intratympanically. On the fifth group (n=6), 0.9% NaCl were administered intratympanically. In Groups 2, 3, 4 and 5, cisplatin was given 30 minute after the administration of medication. ABR and DPOAE tests were performed on all groups before and 72 h after the procedure. Results: The post-treatment ABR I, ABR IV and ABR threshold values of the groups were found to be significantly higher than the pre-treatment values (p<0.001). There was no significant prolongation of the post-treatment ABR I-IV interval in the oxytocin and dexamethasone groups (p>0.05). Pre-treatment values were higher than post-treatment values in all groups. There was no significant decrease in the frequencies of 2832 and 4004 after treatment in the oxytocin and dexamethasone group compared to pre-treatment. No difference was found between the oxytocin and dexamethasone groups (p>0.05). Conclusion: As a result, it has been shown that intratympanic oxytocin may be an option that can be used in the treatment, although it is not as effective as dexamethasone in preventing cisplatin ototoxicity.
Epithelial tumor compartment- and adjacent stromal compartment-specific expression of PARP1 in different anatomical sites in patients with HGSOC
Authors: BERKEL CAGLAR , CACAN Ercan 
Published: June 2022

Abstract
High-grade serous ovarian carcinoma (HGSOC) is responsible for the majority of ovarian cancer-associated deaths. PARP (Poly-(ADP-ribose) polymerase) inhibitors (PARPi) (olaparib, rucaparib and niraparib) have been approved in recent years to be used in both the frontline setting as maintenance therapy and in the recurrent setting for patients with ovarian cancer (OC). Previous studies have reported increased expression of PARP1, a sensor for DNA damage, in OC; however, its compartment (epithelial tumor vs stroma)-, anatomical site (fallopian tube, omentum, ovary and serous tubal in situ carcinoma)- and histotype-specific expression have not been studied. Here, we showed that PARP1 protein levels are higher in epithelial tumors compared to adjacent stroma at four different anatomical locations in HGSOC, with the most significant difference in PARP1 levels in omental metastases. Furthermore, we found that PARP1 protein levels are higher in tumors compared to normal tissue in fallopian tube, omentum and ovary in patients with HGSOC, again with the most significant difference in omentum. We showed that S100A4 and CLDN7, transcriptional targets of PARP1, have the highest copy numbers in serous OC among all cancer types, showing the potential OC-specific roles of these two proteins. We also showed that PARP1 expression is increased in malignant and invasive stage in mouse ovarian surface epithelium cells, and that PARP1 mRNA levels are lower in mucinous histotype compared to serous histotype of epithelial OC. These findings indicate that a better understanding of compartment-, anatomical location- and histotype-specific changes in PARP1 levels in OC is needed, since PARP inhibitors which work by preventing DNA repair in cancer cells are currently being used in the treatment of patients with OC.
Improved chromosome genome assembly, structural variation insight, and annotation of Gossypium barbadense L. 'Pima-S6'
Authors: Herrera-Estrella Luis 
Published: June 2022

Abstract
Gossypium barbadense L. Pima cotton is known for its resistance to Fusarium wilt and for producing fibers of superior quality highly prized in the textile market. We report a high-quality genome assembly and annotation of Pima-S6 cotton and its comparison at the chromosome and protein level to other ten Gossypium published genome-assemblies. The analyses revealed important differences on structural variations and annotated proteins between our Pima-S6 and other publicly available G. barbadense assemblies, and across Gossypium assemblies in general. Detailed synteny analyses reveals chromosomal rearrangements between Pima-S6 and other Gossypium genomes on several chromosomes. Analyses of the re-assembled and re-annotated genome of the close relative G. barbadenses Pima 3–74 using our Pima-S6 assembly, suggest that contig placement of the most recent G. barbadense assemblies might have been unduly influenced by the use of the G. hirsutum TM-1 genome as the anchoring reference. The Pima-S6 reference genome provides a valuable genomic resource and offers new insights of genomic structure and can serve as G. barbadense genome reference for future assemblies and further support FOV4-related studies and breeding efforts.
The effect of roasting on the antioxidant and antibacterial capacity of coffee cherry husk extract
Authors: Mesfin Korsa , Admassu Habtamu , Gobena Feyera , Belayneh Tilahun 
Published: June 2022

Abstract
The coffee cherry process generates huge amounts of byproducts which are disposed of on the land, causing a serious environmental problem. The coffee cherry husk is one of the main byproducts generated from dry coffee processing, which contains many high-value and exhibits antioxidative and antimicrobial properties biomolecules including phenols, tannins and flavonoids. The primary goal of this study was to investigate the effects of roasting temperatures (150–200 °C) and times (10–25 minutes) on the yield, total phenol, tannin, and flavonoid content, as well as the antioxidant and antimicrobial capacity of an ethanol extract obtained from the coffee cherry husk using an automatic solvent extractor. In this study, the extract yield, total phenol and flavonoid content, as well as the antioxidant and antimicrobial capacity of roasted coffee cherry husk extract were enhanced by roasting. The extract yield ranged between 6.22 ± 0.08–16.37 ± 0.61%. The total phenol and flavonoid content ranged from 9.00 ± 0.03–123.49 ± 0.21 mg gallic acid equivalent/g and 2.69 ± 0.26–35.34 ± 0.13 mg quercetin equivalent/g, respectively. As roasting temperature and time increased, total tannin decreased from 42.45 ± 0.20 to 0.27 ± 0.04 mg tannic acid equivalent/g. The 2, 2-diphenyl-1-picrylhydrazyl radical and hydrogen peroxide scavenging capacities extended from 24.68 ± 0.05–93.83 ± 0.11% and 14.45 ± 0.19–76.07 ± 0.16% respectively, while the ferric reducing capacity ranged from 10.85 ± 0.09–47.02 ± 0.20 mg ascorbic acid equivalent/g. The bacterial inhibition zones extended from 7.03 ± 0.56–21.30 ± 0.27 mm and 6.00 ± 0.00–15.77 ± 0.25 mm for Escherichia coli and Staphylococcus aureus, respectively.
Evaluating the performance of Bayesian and Frequentist Approaches for longitudinal modeling: Application to Alzheimer's Disease
Authors: Pérez-Millan Agnès , Contador José , Tudela Raúl , Niñerola-Baizán Aida , Setoain Xavier , Lladó Albert , Sánchez-Valle Raquel , Sala-Llonch Roser 
Published: June 2022

Abstract
Linear Mixed Effects (LME) modelling under both frequentist and Bayesian frameworks have been suggested to study longitudinal trajectories. We studied the performance of both approaches on different dataset configurations using hippocampal volumes from longitudinal MRI data across groups - healthy controls (HC), mild cognitive impairment (MCI) and Alzheimer’s Disease (AD) patients -, including subjects that converted from MCI to AD. We started from a big database of 1250 subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and we created different reduced datasets simulating real-life situations using a random-removal permutation-based approach. The number of subjects needed to differentiate groups and to detect conversion to AD was 147 and 115 respectively. The Bayesian approach allowed estimating the LME model even with very sparse databases, with high number of missing points, which was not possible with the frequentist approach. Our results indicate that the frequentist approach is computationally simpler, but it fails in modelling data with high number of missing values.
Does teneligliptin reverse the non-glycemic effects among the non-diabetic obesity subjects?
Authors: Pelluri Ranakishor , Kongara Srikanth , Nagasubramanian Vanitha Rani , Mahadevan Shriraam , Chimakurthy Jithendra 
Published: June 2022

Abstract
Incretins (GLP-1, GIP, DPP-4) are secreted in response to meal. The GLP-1 has very shorter half-life (1–2 min), meanwhile it was degraded by DPP-4 enzyme. The present novel, Teneligliptin which has greatest receptor selectivity and has longer half-life compared to other gliptins. The promising dipp-4 inhibition which can enhance the GLP-1 concentration in the blood. Augmentation of GLP-1 levels are helpful to reduce the weight loss in obesity subjects along with reversing metabolic syndrome components. GLP-1 analogues are gold mine and are succeeded in subjects with obesity. Apart from pharmacotherapy, lifestyle modification in the form of strict diet restrictions and physical exercise are the corner stone intervention for obesity, but subjects are filed to achieve it. Furthermore, there are currently few anti-obesity drugs available, and additional safe and effective therapeutic options for the treatment of obesity are needed. Teneligliptin is developed to treat diabetes, and which do not produce hypoglycaemic effect alone. Hence, considering its safety we are aimed evaluate the non-glycemic effects in non-diabetic obese subjects. The present prospective study was registered in the Clinical trial registry of India, Regd. ID: CTRI/2020/02/023329 [Registered on: 14/02/2020].
Ramming mechanical characteristics of rammed earthen sites
Authors: Pei QiangQiang , Liu Xiaoying , HOU Zhichun , ZHAO Guojing , Zhang Bo , Guo QingLin 
Published: June 2022

Abstract
The ramming technique is a traditional method used to improve the compactness of soil with impact and vibration energy. Based on the measured data of ramming force transmission and dissipation, this study reveals the mechanism of energy transfer and dissipation of single-layer ramming as well as the law of variation with ramming quality, laying thickness, and ramming times. It also establishes the ramming model and empirical formula of ramming quality, laying thickness, and ramming times, introduces the ramming layer changes associated with the constitutive relationship (elastic to elastoplastic parts) as a function of ramming times, and determines the influence depth and horizontal range based on real-time data monitoring. It was found that as the mass of the rammmer increases, the range of influence of the impact stress inside the earth also increases proportionally, and this effect is more pronounced vertically. However, the dissipation rate of energy in horizon direction is much greater than in the vertical direction. The traditional stacked ramming technique of “chong hai wo, hang yin ding” can effectively eliminate the defects of horizontal reversal upwelling impact and unevenness of the ramming layer during the ramming process. The research results provide a theoretical basis for evaluating the quality of the traditional ramming technique.
Determining factors of neonatal kernicterus among neonates treated in NICU in health care centres of West Guji Zone, Suthern, Ethiopia,
Authors: Degavi Girish 
Published: June 2022

Abstract
Background
Kernicterus in infants is a medical challenge that is linked to infant death throughout the world. Extreme jaundice with or without Kernicterus affects roughly one million newborns internationally every year, with overall majority of instances happening in south Asia and Sub-Saharan Africa. There are far more techniques and understanding about the etiology of infant ictrus in Sub-Saharan Africa. It is indeed vital to look into the causes that induce infant kernicterus in order to decrease infant morbidity and mortality rates.
Methodlogy
: A hospital-based unmatched case control study was carried out by evaluating systematically chosen charts of 544 neonates in the neonatal critical care unit of public general hospitals in the West, Guji Zone, Ethiopia. The information was gathered using an extraction format. For analysis, data were entered into epidata management version 4.4.2.1 and exported to SPSS version 20. The binary logistic regression model was employed to assess the relationship between independent and dependent variables.
Results
; A total of 272 neonatal cards were included. Obstetric complication [AOR: 5.77 at 95%CI: 1.85–17.98], low birth weight [AOR: 4.27at 95%CI: 1.579–11.555], birth asphyxia [AOR: 4.83 at 95%CI: 1.617–14.395], RH-incompatibility [AOR: 5.45 at 95%CI: 1.583–18.737], breast feeding [AOR: 6.11at 95%CI: 1.707–21.886], policytemia [AOR: 7.32 at 95%CI: 2.512–21.311], were the determinants of neonatal kernicterus.
Conclusion
Obstetric difficulties, birth hypoxia, breastfeeding, RH-incompatibility, low birth weight, and policytemia are all causes of Neonatal kernicterus. As more than just a consequence, this one was determined that detecting and treating infant kernicterus early on is crucial because it can cause life-threatening complications in newborns.
Cortex or Cancellous —— Which is early for the Decrease of Bone Content for veterbral body in health?
Authors: Bai Lin , Li Jujia , Ren Congcong , Wang Ming , Yang Fan , Li Qian , Zhao Jian , Zhang Ping 
Published: June 2022

Abstract
Objective
To obtained the cortex and cancellous parameter of the vertebral bone of healthy subjects using QCT. To expore which is early and faster for bone loss with age.
Materials and methods
733 physical examiners underwent chest low-dose CT examination were recruited, from January 1, 2021 to December 31, 2021. QCT sequence was used to obtain the bone mineral density of T12-L2 vertebral body without radditional radiation.The mass and area of vertebral cortex and cancellous at the central level of L2 vertebral bodywere measured. The characteristics of vertebral cortex and cancellous with age were analyzed and compared.
Results
Significant differences were found involumetricbone mineral density (vBMD) of T12-L2verterbal body, cortical mass, cancellous mass, cortical area, cortical mass / cancellous mass and cortical area / cancellous area in different age groups, respectively.No significant difference was found in all groups for cancellous area. ThevBMD of T12-L2 vertebral body decreased with age; The cortical mass decreased gradually before 71y.The cancellous mass increased and then decreased with peak at 31-40y.The cortical area decreased gradually before 71y.The cancellous area increasedand then decreased with peak at the age of 41–50.The values of cortical mass/cancellous mass showed a slowly downward trendwith age. The values of cortical area / cancellous area decerased before 61y.
Conclusion
The changes of vertebral BMD, bone content ofcortex and cancellous have different characteristics in different age. The change of cortex may be earlier and faster than that of cancellous with age.
Information Management under uncertain large-scale cloud environment
Authors: OMRI Asma , OMRI Waleed , Benslimane Djamal , OMRI Mohamed-Nazih 
Published: June 2022

Abstract
“Uncertainty” is related to working with inaccurate data, imprecise and incomplete information, and unreliable results that can lead to irrational decisions. Several approaches to managing uncertain data on the web have been proposed in the literature to resolve this problem. These approaches have failed to find the solution to this problem with accuracy and performance. Our study aims to propose a new probabilistic approach to manage web information resources in an uncertain large-scale cloud environment. Our approach is based on three main steps: (1) modeling uncertain web resources, (2) computing HTTP request model, and (3) interpretation and evaluation of uncertain web resources in a context of classic hypertext navigation. The experimental study shows that the analysis of the execution time necessary for the composition of the services, by our approach, is negligible, compared to that of the other studied approaches. The algorithm which deals with the impact of the variation in the number of nodes, which we have proposed, has also been evaluated and checks all the possibilities in polynomial time and can adapt to many possibilities of multiplexing of values.