bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health‐related quality of life of people with type 2 diabetes and its associated factors at a tertiary care clinic in Ningbo, China: A cross‐sectional study
Authors: Carter Naomi , Li Jialin , Xu Miao , Li Li , Fan Xuelan , Zhu Shuyan , Chahal Pritpal , Chattopadhyay Kaushik 
Published: July 2022

AbstractIntroductionThe burden of type 2 diabetes (T2DM) in China is increasing, with potential impacts on the health‐related quality of life (HRQoL) of those who develop the disease. Context‐specific assessment of HRQoL and its associated factors informs the development of contextually appropriate interventions to improve HRQoL. This study aimed to determine the HRQoL and its associated factors in people with T2DM at a tertiary care clinic in Ningbo, China.MethodsA cross‐sectional survey was undertaken among 406 people with T2DM in 2020–21. The primary outcome was HRQoL measured using EQ VAS and EQ‐5D index from the EQ‐5D‐3L questionnaire. Multivariable regression analysis was used to determine the factors associated with HRQoL scores.ResultsThe mean (± standard deviation) EQ VAS score was 68.7 (13.8). Median (interquartile range) EQ‐5D index was 1 (0.027). Prevalence of problems in HRQoL domains was as follows: pain/discomfort (15.7%), anxiety/depression (13.3%), mobility (5.4%), self‐care (3.5%) and managing usual activities (5.2%). The ≥60 years age group had a mean EQ VAS score 8.7 points higher (95% CI 3.4, 13.9; p < .001) than the 18–39 years age group. Those with T2DM >10 years had a mean EQ VAS score 8.6 points lower than those with a duration <1 year (−12.8, −4.4; p = .001). A T2DM duration >10 years was associated with a reduction in the EQ‐5D index of 0.029 (−0.041, −0.016; p < .001) compared with a duration <1 year.ConclusionsDepression/anxiety and pain/discomfort are important domains of reduced HRQoL for this population. A longer duration of T2DM is associated with reduced HRQoL scores, including both EQ VAS and EQ‐5D index. Increasing age may be counterintuitively associated with an increase in EQ VAS score in this population, potentially reflecting a ‘paradox of aging’ process. Future work should focus on developing, evaluating and implementing interventions to improve HRQoL in T2DM, such as strategies to manage pain and mental health conditions.
Midazolam versus morphine in acute cardiogenic pulmonary oedema: results of a multicentre, open‐label, randomized controlled trial
Authors: Domínguez‐Rodríguez Alberto , Suero‐Mendez Coral , Burillo‐Putze Guillermo , Gil Victor , Calvo‐Rodriguez Rafael , Piñera‐Salmeron Pascual , Llorens Pere , Martín‐Sánchez Francisco J. , Abreu‐Gonzalez Pedro , Miró Òscar ,   MIMO (MIdazolam versus MOrphine) Trial Investigators
Published: July 2022

AbstractAimsBenzodiazepines have been used as safe anxiolytic drugs for decades and some authors have suggested they could be an alternative for morphine for treating acute cardiogenic pulmonary oedema (ACPE). We compared the efficacy and safety of midazolam and morphine in patients with ACPE.Methods and resultsA randomized, multicentre, open‐label, blinded endpoint clinical trial was performed in seven Spanish emergency departments (EDs). Patients >18 years old clinically diagnosed with ACPE and with dyspnoea and anxiety were randomized (1:1) at ED arrival to receive either intravenous midazolam or morphine. Efficacy was assessed by in‐hospital all‐cause mortality (primary endpoint). Safety was assessed through serious adverse event (SAE) reporting, and the composite endpoint included 30‐day mortality and SAE. Analyses were made on an intention‐to‐treat basis. The trial was stopped early after a planned interim analysis by the safety monitoring committee. At that time, 111 patients had been randomized: 55 to midazolam and 56 to morphine. There were no significant differences in the primary endpoint (in‐hospital mortality for midazolam vs. morphine 12.7% vs. 17.9%; risk ratio[RR] 0.71, 95% confidence interval [CI] 0.29–1.74; p = 0.60). SAE were less common with midazolam versus morphine (18.2% vs. 42.9%; RR 0.42, 95% CI 0.22–0.80; p = 0.007), as were the composite endpoint (23.6% vs. 44.6%; RR 0.53, 95% CI 0.30–0.92; p = 0.03).ConclusionAlthough the number of patients was too small to draw final conclusions and there were no significant differences in mortality between midazolam and morphine, a significantly higher rate of SAEs was found in the morphine group.
Autistic characteristics in youth with anorexia nervosa before and after treatment
Authors: Susanin Annabel , Cooper Marita , Makara Amanda , Kuschner Emily S. , Timko C. Alix 
Published: July 2022

AbstractObjectiveCognitive characteristics common to autistic individuals are often seen in adults with anorexia nervosa (AN), raising the question of whether autistic people and people with AN may share an endophenotype. We need to examine autistic characteristics during the early stages of AN to accurately parse true symptom co‐occurrence from behavioural alterations due to prolonged illness.MethodsWe conducted a post‐hoc analysis examining autistic characteristics in 59 youth with AN. Adolescents and parents participating in a randomised‐clinical trial for AN completed questionnaires probing autistic characteristics at baseline and treatment end. We categorised participants as above or below cut‐offs of clinical indicators of autism using the Autism Probability Index (API) and the Autism Spectrum Quotient‐10.ResultsRates of high autistic characteristics ranged between 0% and 36% depending on the instrument used and how the data was obtained (i.e., by informant report or self‐report). Paternal report of autistic characteristics differed across treatment completers versus non completers and maternal report indicated lower weight gain for those with elevated characteristics.ConclusionsLow rates of autism and fluctuations in autistic features during treatment underscore the importance of longitudinal examinations of autistic characteristics in adolescents with AN. Future studies need to replicate findings in a larger adolescent sample.Trial registration: ClinicalTrails.gov Identifier NCT03928028.
Bioinspired mechanically interlocking holey graphene@SiO2 anode
Authors: Wang Fei , Liao Xiaobin , Wang Haoyu , Zhao Yan , Mao Jian , Truhlar Donald G. 
Published: July 2022

AbstractMechanically interlocking structures that can enhance adhesion at the interface and regulate the stress distribution have been widely observed in biological systems. Inspired by the biological structures in the wings of beetles, we synthesized a holey graphene@SiO2 anode with strong mechanical interlocking, characterized it electrochemically, and explained its performance by finite element analysis and density functional calculations. The mechanically interlocking structure enhances lithium‐ion (Li+) storage by transmitting the strain from SiO2 to the holey graphene and by a mechano‐electrochemical coupling effect. The interlocking fit hinders the abscission of SiO2 and the distinctive structure reduces the stress and strain of SiO2 during (de)lithiation. The positive mechano‐electrochemical coupling effect preserves the amount of electrochemically active phase (LixSi) during cycles and facilitates Li+ diffusion. Therefore, the capacity shows only a slight attenuation after 8000 cycles (cycling stability), and the specific capacity is ~1200 mA h g−1 at 5 A/g (rate‐performance). This study furnishes a novel way to design high‐performance Li+/Na+/K+/Al3+ anodes with large volume expansion.
Evaluating the efficacy of ovulation stimulation with intrauterine insemination in women with diminished ovarian reserve compared to women with normal ovarian reserve
Authors: Kaleli Semih , Kervancıoğlu Mehmet E. , Erol Naciye , Alakbarova Ulviyya , Akşahin Elif , Öçer İsmail F. 
Published: July 2022

AbstractObjectiveTo assess the efficacy of ovulation induction and intrauterine insemination (IUI) in couples with diminished ovarian reserve (DOR).MethodsWomen aged 20–39 years and men younger than 50 years were included. Four “ovarian reserve groups” were created according to anti‐Müllerian hormone (AMH) and the partner's age. Gestational sac finding on ultrasound examination was the primary outcome measure.ResultsThe study was carried out on a total of 770 cycles of 362 women in an infertility cohort that consisted of 75 women with DOR treated by 153 cycles and 287 women without DOR treated by 617 cycles. The pregnancy rate was similar in the four ovarian reserve groups in terms of first, second, third plus fourth, and total attempts of IUI cycles. Moreover, the pregnancy rate, miscarriage rate, and multiple pregnancy rate were similar. We found no difference in the cumulative pregnancy rate among the groups after four IUI cycles. Multivariate logistic regression analysis of the entire cohort revealed that infertility duration, post‐wash sperm count, and follicle number greater than 11 mm on the day of human chorionic gonadotropin trigger were independent predictors of pregnancy (P < 0.001). Neither age nor AMH predicted pregnancy after ovulation stimulation and IUI.ConclusionsOvulation stimulation and IUI are equally effective in women with DOR and in women with normal ovarian reserve in terms of pregnancy rate, multiple pregnancy rate, and miscarriage rate per IUI cycle or cumulative pregnancy rate after four cycles of IUI.
Existence of chronic endometritis and its influence on pregnancy outcomes in infertile women with minimal/mild endometriosis
Authors: Qiao Xinyu , Wu Lukanxuan , Liu Dong , Pei Tianjiao , Huang Wei 
Published: July 2022

AbstractObjectiveThis study aimed to evaluate the prevalence of chronic endometritis (CE) in women with minimal/mild endometriosis and to analyze whether CE affects their pregnancy outcomes.MethodsThis retrospective study included 201 infertile women who were diagnosed with minimal/mild endometriosis after undergoing hysteroscopy combined with laparoscopy from January 2016 to December 2018. Immunohistochemistry was used to detect CD138 and CD38, which are specific markers of plasma cells in the endometrial stroma to diagnose CE. Subsequently, we investigated the prevalence of CE and the effects of CE on spontaneous cumulative pregnancy rate, live birth rate, and miscarriage rate within 24 months after surgery.ResultsThe prevalence of CE in infertile women with minimal/mild endometriosis was 24.38%. Patients diagnosed with CE showed a significantly lower cumulative pregnancy rate and live birth rate compared with women without CE (46.51% vs. 71.13% [P = 0.004]; 44.19% vs. 63.38% [P = 0.025]). However, the rate of miscarriage in women with CE was also lower than in women without CE (0 vs. 7.04%, P = 0.074).ConclusionSince CE had an adverse effect on cumulative pregnancy rate and live birth rate in infertile women with minimal/mild endometriosis, we suggested that diagnosis and treatment of CE may improve their pregnancy outcomes.
Efficacy of the new adjustable I‐stop‐mini sling system in women with stress urinary incontinence and intrinsic sphincter deficiency: A retrospective cohort study
Authors: Chao Wei‐Ting , Chen Guan‐Yeu , Liu Chia‐Hao , Chang Chia‐Pei , Wang Peng‐Hui , Horng Huann‐Cheng 
Published: July 2022

AbstractObjectiveWe aimed to evaluate the efficacy, surgical outcomes, and adverse events of the adjustable midurethral sling I‐stop‐mini in women with intrinsic sphincter deficiency (ISD)–type stress urinary incontinence. We compared this new sling system with the Obtryx transobturator midurethral sling system.MethodsThis retrospective cohort study was conducted at a single center from June 2017 to December 2020. A total of 141 women who underwent placement of an I‐stop‐mini or Obtryx and were followed up for at least 1 year were enrolled. ISD was defined as a Valsalva leak point pressure of ≤60 cmH2O or a maximal urethral closure pressure of ≤20 cmH2O. Student t test was used to compare continuous variables, and chi‐square test was used to compare the distribution of categorical data.ResultsIn terms of objective success, I‐stop‐mini and Obtryx showed no significant differences in the postoperative 1‐month, 6‐month, and 12‐month. The two devices showed similar effectiveness regardless of the ISD definition. The I‐stop‐mini group had a significantly shorter operative time, whereas the adverse event rates were similar.ConclusionThe subjective cure rate, objective success, and adverse event rate did not differ in the two devices. I‐stop‐mini had a significantly shorter operative time.
Causative factors, social and surgical outcomes of vesicovaginal fistulas treated via an abdominal transvesical approach: A single‐center experience
Authors: Asif Muhammad , Abrar Saida , Abrar Tahira 
Published: July 2022

AbstractObjectiveTo study the demographics, and surgical and social outcomes of patients with fistula repair performed at our hospital.MethodsThis cross‐sectional study included 120 patients with fistula repair performed between 2014 and 2019 in the Urology Department of Lady Reading Hospital, Peshawar using an open transvesical repair method without omental interposition. Data were collected on patients' demographics, and social and surgical outcomes. Fistula severity was assessed using the International Consultation on Incontinence Questionnaire‐Short Form (ICIQ‐SF).ResultsAbout 80 (66.6%) fistulas were iatrogenic and 40 (33.3%) were ischemic, with 36 (90%) due to obstructed labor. The median age of patients was 36 years (29–40 years). The majority of the patients were multiparous and premenopausal (99; 82.5%). Fifty (56.5%) of the iatrogenic fistulas were due to non‐obstetric hysterectomy, and 20 (25%) were due to cesarean hysterectomy. Women had the fistulas for 4–49 weeks before seeking treatment with an average ICIQ score of 18. In all, 73 (73%) of the fistula caused by delivery had involved stillbirths, 4 (3.96%) were early neonatal deaths, and nearly 25 (21%) of patients were divorced. About 114 (95%) of patients were completely cured on discharge.ConclusionVesicovaginal fistula is a devastating condition, with a rising trend in iatrogenic fistulas in low‐income countries. In the hands of experienced surgeons, trans‐abdominal repair without omental interposition shows a high success rate.
Secretion of the disulphide bond generating catalyst QSOX1 from pancreatic tumour cells into the extracellular matrix: Association with extracellular vesicles and matrix proteins
Authors: Millar‐Haskell Catherine S. , Sperduto John L. , Slater John H. , Thorpe Colin , Gleghorn Jason P. 
Published: July 2022

AbstractQuiescin sulfhydryl oxidase 1 (QSOX1) is a disulphide bond generating catalyst that is overexpressed in solid tumours. Expression of QSOX1 is linked to cancer cell invasion, tumour grade, and aberrant extracellular matrix (ECM) protein deposition. While the secreted version of QSOX1 is known to be present in various fluids and secretory tissues, its presence in the ECM of cancer is less understood. To characterize secreted QSOX1, we isolated extracellular vesicles (and particles) (EV(P)s) from conditioned media using ultracentrifugation and separated the supernatant using tangential flow filtration. We discovered that most of the secreted QSOX1 resides in the EVP‐depleted supernatant and in the soluble protein fraction. Very little QSOX1 could be detected in the EVP fraction. We used immunofluorescence to image subpopulations of EVs and found QSOX1 in Golgi‐derived vesicles and medium/large vesicles, but in general, most extracellular QSOX1 was not attributed to these vesicles. Next, we quantified QSOX1 co‐localization with the EV marker Alix. For the medium/large EVs, ∼98% contained QSOX1 when fibronectin was used as a coating. However, on collagen coatings, only ∼60% of these vesicles contained QSOX1, suggesting differences in EV cargo based on ECM coated surfaces. About 10% of small EVs co‐localized with QSOX1 on every ECM protein surface except for collagen (0.64%). We next investigated adhesion of QSOX1 to ECM proteins in vitro and in situ and found that QSOX1 preferentially adheres to fibronectin, laminins, and Matrigel compared to gelatin and collagen. This mechanism was found to be, in part, mediated by the formation of mixed disulphides between QSOX1 and cysteine‐rich ECM proteins. In summary, we found that QSOX1 (1) is in subpopulations of medium/large EVs, (2) seems to interact with small Alix+ EVs, and (3) adheres to cysteine‐rich ECM proteins, potentially through the formation of intermediate disulphides. These observations offer significant insight into how enzymes, such as QSOX1, can facilitate matrix remodelling events in solid tumour progression.
Systematic review and meta‐analysis of difficulty scoring systems for laparoscopic and robotic liver resections
Authors: Linn Yun‐Le , Wu Andrew G. , Han Ho‐Seong , Liu Rong , Chen Kuo‐Hsin , Fuks David , Soubrane Olivier , Cherqui Daniel , Geller David , Cheung Tan‐To , Edwin Bjørn , Aldrighetti Luca , Abu Hilal Mohammad , Troisi Roberto I. , Wakabayashi Go , Goh Brian K. P. ,   International Robotic and Laparoscopic Liver Resection Study Group Investigators
Published: July 2022

AbstractIntroductionThe ability to stratify the difficulty of minimally invasive liver resection (MILR) allows surgeons at different phases of the learning curve to tackle cases of appropriate difficulty safely. Several difficulty scoring systems (DSS) have been formulated which attempt to accurately stratify this difficulty. The present study aims to review the literature pertaining to the existing DSS for MILR.MethodsWe performed a systematic review and metanalysis of the literature reporting on the formulation, supporting data, and comparison of DSS for MILR.ResultsA total of 11 studies were identified which reported on the formulation of unique DSS for MILR. Five of these (Ban, Iwate, Hasegawa, Institut Mutaliste Montsouris [IMM], and Southampton DSS) were externally validated and shown to predict difficulty of MILR via a range of outcome measures. The Ban DSS was supported by pooled data from 10 studies (9 LLR, 1 RLR), Iwate by 10 studies (8 LLR, 2 RLR), Hasegawa by four studies (all LLR), IMM by eight studies (all LLR), and Southampton by five studies (all LLR). There was no clear superior DSS.ConclusionThe existing DSS were all effective in predicting difficulty of MILR. Present studies comparing between DSS have not established a clear superior system, and the five main DSS have been found to be predictive of difficulty in LLR and two of these in RLR.
Synthesis and evaluation of a new series of spiro aryl dioxolane compounds: A new scaffold as potential poly(ADP‐ribose)polymerase‐1 (PARP‐1) inhibitors
Authors: Maigali Soher S. , El‐Shanawany Hala R. , El‐Sayed Naglaa F. , Youssef Mohamed A. , Fouad Marwa A. 
Published: July 2022

AbstractA new series of spiro aryl dioxolane derivatives were synthesized and evaluated to find a new scaffold as potential poly(ADP‐ribose)polymerases‐1 (PARP‐1) inhibitors. This key starting compound, 2,6‐bis(methoxybenzylidene)cyclohexanone, was functionalized with different nucleophilic reagents via cyclocondensation reactions to obtain new benzylidene scaffolds containing diverse aryl groups such as spiroindazoleorquinazoline [1,3]dioxolane compounds. Furthermore, the Michael addition reaction of bis‐benzylidene with some active methylene compounds afforded spirochromene‐ or naphthalene‐[1,3]dioxolane compounds. All the synthesized compounds revealed promising inhibition with IC50 values in the nanomolar range (0.997–2.698 nM), not significantly different from that of Olaparib (IC50 = 0.861 nM). Compounds 5b and 15 (IC50 = 1.009 and 0.997 nM) showed the highest potency among all the prepared compounds and accordingly their ability to inhibit the growth of BRCA1 mutated breast cancer cell line MDA‐MB‐436 was tested, where compound 5b (IC50 = 0.67 μM) showed a potency ten folds higher than that of Olaparib but compound 15 (IC50 = 7.47 μM) exerted lower activity but still comparable to that of Olaparib (IC50 = 6.84 μM). Both resulted in the arrest of cell cycle at S phase and caused cell apoptosis. In silico studies including absorption, distribution, metabolism, excretion (ADME) properties, drug‐likeness, and molecular docking were carried out to support the above‐mentioned findings. This work presents compounds 5b and 15 as promising scaffolds as PARP‐1 inhibitors.
Long‐term (2001–2020) trend analysis of temperature and rainfall and drought characteristics by in situ measurements at a tropical semi‐arid station from southern peninsular India
Authors: Thotli Lokeswara Reddy , Gugamsetty Balakrishnaiah , Kalluri Raja Obul Reddy , Tandule Chakradhar Rao , Kotalo Rama Gopal , Akkiraju Bhavyasree , Lingala Siva Sankara Reddy 
Published: July 2022

AbstractWith the effects of climate change prevailing worldwide, it is essential to understand the long‐term rainfall and temperature trends at regional scales to plan for adaptation strategies. Investigating the temporal dynamics of meteorological variables in climate‐induced changes, particularly in rain‐fed agriculture countries such as India, is needful. The present study focused on the temporal variation of rainfall and temperature trends to analyse the drought characteristics over the past 20 years (2001–2020) using ground‐based Automatic Weather Station (AWS) data at a semi‐arid station Anantapur in southern peninsular India. The seasonal maximum mean temperature (Tmean) was observed in summer (32.20 ± 1.36°C), followed by the monsoon (29.08 ± 1.02°C), postmonsoon (26.45 ± 2.44°C), and winter (25.45 ± 1.01°C) during the study period. The Mann–Kendall trend test result showed the decreasing trend in seasonal mean temperature during the drying period (winter [−0.069°C·year−1] and summer [−0.081°C·year−1]) and increasing trend in the wetting period (monsoon [0.012°C·year−1] and postmonsoon [0.034°C·year−1]). On the other hand, the seasonal rainfall decreases in the postmonsoon (−2.276 mm·year−1) while increasing in winter (0.5 mm·year−1), summer (2.137 mm·year−1), and monsoon (6.901 mm·year−1) seasons. The annual trends of minimum, maximum, and mean monthly temperatures decrease at the rate of −0.121, −0.123, and −0.022°C·year−1, respectively, while the rainfall increases at the rate of 8.979 mm·year−1. Furthermore, the temporal evolution of meteorological drought characteristics was estimated with the help of the standardized precipitation index (SPI) and standardized precipitation evapotranspiration index (SPEI) on multiple timescales ranging from 1 to 24 months on a monthly basis during the study period. The 24‐month SPI values showed that 1 “severely dry” and the 29 “moderately dry” long‐term drought events were observed. From 24‐month SPEI, a total of 15 “severely dry” and 20 “moderately dry” long‐term droughts were observed during the study period. The severely dry years were observed in 2002 and 2003, while the wettest periods were 2007 and 2010. Both indices are identified as more severe dry periods from 2002 to 2006 and 2013 to 2017 than rest periods. Also, a significant decreasing tendency of droughts was observed in both indices. The SPI values are compared with El Niño–Southern Oscillation (ENSO) and normalized difference vegetation index (NDVI) and found that the SPI versus ENSO index negatively correlates with the coefficient of −0.58 significantly, while the SPI versus NDVI correlation is insignificant. The study region converted to wetter conditions during the last 20 years.