bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of cumulative damage to a solid rocket motor grain during highway transportation
Authors: cui jiayuan , Qiang Hongfu , Wang Xueren , wang jiaxiang 
Published: September 2022

Abstract

Due to strategic requirements, tactical missiles need to be transported several times before they are launched. For this reason, this study examined the cumulative damage that occurs in a solid rocket motor grain during road transportation. Constant-stress reciprocating tensile tests of a composite solid propellant were designed and carried out, and the characteristic fatigue curve of the propellant was fitted and analyzed. By processing power spectral density data for equipment transportation tests, a vibration acceleration load spectrum for a solid rocket motor grain in the process of highway transportation was obtained. A three-dimensional finite-element calculation model of a solid rocket motor was established, and the stress response of the motor grain was simulated. After this, cyclic loads were obtained using a rainflow counting method. The cumulative damage to the solid rocket motor grain during highway transportation was calculated according to Miner’s linear cumulative-damage model and evaluated. It was concluded that during transportation, the maximum stress of the solid rocket motor is 0.2 MPa, the maximum strain is 0.03, and the maximum displacement is 19.32 mm, all of which are found in the front stress-release boot. After 4000 km driving on the highway, the damage to the front stress-release boot of the grain is thus the greatest, with a value of 0.0796. The damage to the inner hole of the grain was found to be the smallest, with a value of 0.0438.
Histone methyltransferases inhibitors against Babesia in vitro
Authors: Li Xiaoyun , Wang Jinming , Wang Yanbo , Nian Yueli , Zhao Shuaiyang , Liu Junlong , Luo Jianxun , Yin Hong , Guan Guiquan 
Published: September 2022

Abstract
Babesiosis causes negative impact on health of human, domestic animals and wildlife. Currently, the limited strategies of immunoprophylaxis and chemotherapy hinder effective control of babesiosis. In this study, an in vitro screening assay was performed to identify compounds targeting to histone methyltransferase and showing high performance against growth of Babesia sp. Xinjiang (Bxj). We also evaluated their cytotoxicity on MDOK cell line. Eight compounds showed variable degrees of antibabesial activity. Among these, Furamidine showed outstanding activity at nanomolar level of half inhibitive concentration (IC50) in vitro. It also showed low cytotoxicity, of which 50% growth inhibition (CGI50) on MDOK cell line was ~ 100 µM at 24 h, ~ 45 µM at 48 h and ~ 40 µM 72 h. The selective index (SI) (calculated by CGI50/IC50) was higher than 1,500. Our findings support that histone methyltransferases are potential targets for developing alternative drugs to control babesiosis.
Synthesis of solid acid catalysts of MgO–Al2O3 mixed oxide containing oxyanions by thermal decomposition of anion-exchanged hydrotalcites
Authors: Matsuhashi Hiromi 
Published: September 2022

Abstract

Solid acid catalysts of MgO–Al2O3mixed oxides containing B4O72−, HPO42−, Mo7O246−, MoO42−, WO42−, and SO42−were synthesized by anion exchange with Cl−located in the space between anionic layers of hydrotalcite, followed by heat treatment at 773 K. The distance between the hydroxide layers of hydrotalcite was expanded by the intercalation of oxyanions larger than Cl−. The exchange of oxyanions in the interlayer space was confirmed by IR spectroscopy. Acid sites were generated on the obtained mixed oxides of MgO–Al2O3by the electron withdrawing effect of the oxyanions. The effect of exchanged anions in the generation of acid sites was the largest in SO42−.
Initially with pure parkinsonian phenotype of spinocerebellar ataxia type 3: A rare case report and literature review
Authors: Wang Ting-Ling , Gang Wu , Liu Su-Zhi 
Published: September 2022

Abstract
Background
Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal dominant genetic disease with substantial heterogeneity in clinical manifestations. It typically starts with ataxia and can be divided into five subtypes. The fourth subtype of SCA3 is characterized by parkinsonian and peripheral neuropathy. However, this phenotype is rare, and it tends to be easily misdiagnosed as Parkinson's disease.
Materials and methods
We report a 51-year-old female patient who initially presented with pure parkinsonian symptoms at the age of 30. She responded well to levodopa treatment and had a diagnosis of Parkinson's disease for almost 20 years. Ataxia symptoms, symptom fluctuations and dyskinesia occurred in the late stage of the disease. A literature review was included to summarize the clinical features of the fourth subtype of SCA3 (type IV SCA3) and its relevant pathogenesis.
Results
Type IV SCA3 with 66 CAG repeats was diagnosed by genetic testing. It is initially characterized by a pure parkinsonian phenotype indistinguishable from PD, short CAG repeat expansions, and a good response to levodopa.
Conclusion
Type IV SCA3 should be considered when diagnosing Parkinson's disease, especially in those with a family history. More research is needed to detect the pathogenesis of the parkinsonism phenotype in type IV SCA3.
Pre-hydrolysis kraft dissolving pulp from Bambusa vulgaris and Dendrocalamus asper bamboos biomass
Authors: Costa Marcelo Moreira , Silva Weslley Henrique Martins , Bittencourt Ricardo Carvalho , Borges Felipe Pedersoli , Silva Priscila Moreira , Valverde Sebastião Renato 
Published: September 2022

Abstract

In Brazil, bamboo emerges as a potential non-wood raw material as alternative lignocellulosic biomasses source, since this crop has high rusticity and productivity. It grows even in poor soil and shortage of water conditions, and it has a harvest cycle close to 2 years. This study aimed to produce dissolving pulp from the bamboo species Bambusa vulgaris and Dendrocalamus asper seeking to optimize the process conditions, in order to obtain a final product with the specification’s parameters for viscose grade. Bamboo chips of Bambusa vulgaris and Dendrocalamus asper with 2 years old were submitted to pre-hydrolysis kraft pulping process. After pre-hydrolysis kraft pulping Bambusa vulgaris showed screened yield of 34.2% and a xylan content of 3,47% and Dendrocalamus asper showed screened yield of 34,7% and a xylan content of 2,65. Based on these results, only Dendrocalamus asper was selected and bleached. After optimizing the bleaching process the final kappa number of 0.20, viscosity of 465 dm3/kg and 90.6% brightness were obtained for Dendrocalamus asper. Were achieved 1,76% of xylan, 98,1% of glycan and 0.10% of ash content. Was concluded that Dendrolocamus asper can be applied for the production of dissolving pulp. The CCE stage, under the established conditions, did not show to be efficient in removing the xylans from Dendrocalamus Asper brown pulp. On the other hand, further work is needed to optimize the main stages of the process, such as the pre-hydrolysis connected to kraft pulping, as well as the stabilization of carbohydrates chains against bleaching oxidants.
Defining conservation areas through diversity parameters and museum specimens: a case study for craneflies
Authors: Santos Daubian , Santos Charles Morphy D. 
Published: September 2022

Abstract

The perils of climate change turn the definition of conservation areas into an urgent task. With finite financial resources, we must choose efficiently what and where to prioritize. Here, we discuss the benefits of using three parameters - species richness, functional and phylogenetic diversity - to subsidize the proposal of conservation areas complementary to those already existing in Southern South America and New Zealand. The parameters were defined using museum specimens and available taxonomic registers for three genera of craneflies: Aphrophila, Zelandomyia, and Amphineurus (Rhamphoneurus). We found additional priority conservation areas for New Zealand and Southern South America based on maximized species richness, phylogenetic and functional diversity of Aphrophila, Amphineurus (Rhamphoneurus), and Zelandomyia. We plotted the new areas into maps presenting the current conservation areas to compare them. We advocate utilizing all available information on biodiversity for conservation initiatives, including data stored in museums. New Zealand and Southern South America are examples of how dealing with multiple parameters, including criteria that take evolutionary history and species ecology into account, may lead to reliable proposals of priority conservation areas.
Hotspots and trends of layered double hydroxide-based adsorbents for polluted water treatment: Insights from bibliometric analysis
Authors: Paulino Juliana C. P. L. , Silva Anamália F. , Santos Danilo H. S. , Nagliate Patrícia C. , Meili Lucas 
Published: September 2022

Abstract
The use of layered double hydroxides (LDHs) as adsorbent for water treatment has been gaining relevance in recent years. In this context, this work aimed to map, through a bibliometric study, the extent of research that deals with the theme. The scientific database used was the Web of Science, and the chronology of the search consideredthe period from 1997 to 2022. The bibliometix R-package and VOSviewer software were used in this study. The searches retrieved a total of 663 documents, from 69 countries, distributed among all continents, which China (328), India (51) and Japan (40) were the most productive countries. Important journals in the environmental area and with high impact factor, such as Chemical Engineering Journal (44), Applied Clay Science (38), Journal of Hazardous Materials (35) and Chemosphere (27) most published in the area. The network of keywords used by the authors indicates that the publications retrieved deal mainly with aspects related to the efficiency of (LDHs) in the removal of different pollutants, the composition, the synthesis route and the association with other materials and/or techniques. The result of this study constitutes an important tool for directing future research on the subject.
Blood Inflammatory Biomarkers in Participants with Idiopathic Epiretinal Membranes Running Title: Blood Biomarkers for iERM
Authors: Qin Guanghao , You Yue , Shang Mingxin , He Wei , Pazo Emmanuel Eric , Lin Tiezhu 
Published: September 2022

Abstract
Purpose: To evaluate the levels of monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients with Idiopathic Epiretinal Membrane (iERM).
Methods:This retrospective study comprised of participants with iERM and participants with cataract. The values of MLR, NLR, PLR and from participants’ peripheral blood were assessed among groups. The best cutoff value of MLR, NLR, and PLR in iERM was found by performing a receiver operating characteristic (ROC) curve analysis and determining the optimum cutoff value for each variable.
Results: In total, 95 participants with iERM were included in the study group, and 61 participants with senile cataract were included as controls. The lymphocyte count in the iERM group was significantly lower than the control group (1.69±0.63 vs. 1.95±0.53, p=0.003). The monocyte count in the iERM group was significantly higher thanthe control group (0.39±0.11 vs. 0.31±0.10, p<0.001). The area under the curve of MLR, NLR and PLR in differentiating patients with IERM and controls was 0.782, 0.645, and 0.657, respectively, according to ROC. The best cut-off value of MLR was >0.18, with sensitivity and specificity of 74.7% and 75.4% respectively. The NLR was >2.06, with a sensitivity and specificity of 50.5% and 83.6% respectively. The PLR was >95.89, with a sensitivity and specificity of 86.3% and 41.0% respectively.
Conclusion:The findings of this study suggest that systemic inflammation may be associated with iERM. IERM patients may be prone to have high MLR, NLR and PLR values.
Investigating the shared genetic architecture and causal relationship between pain and neuropsychiatric disorders
Authors: Chen Mengya , Li Si , Zhu Ziwei , Dai Chengguqiu , Hao Xingjie 
Published: September 2022

Abstract
Background: Pain often occurs in parallel with many neuropsychiatric disorders. However, the underlying mechanisms and potential causality have not been well studied.
Methods: We collected the genome-wide association study (GWAS) summary statistics of 26 common pain and neuropsychiatric disorders with sample size ranging from 17,310 to 482,730 in European population. The genetic correlation between pair of pain and neuropsychiatric disorders, as well as the relevant cell types were investigated by linkage disequilibrium (LD) score regression analyses. Then transcriptome-wide association study (TWAS) was applied to identify the potential shared genes by integrating the gene expression information and GWAS. In addition, Mendelian randomization (MR) analyses were conducted to infer the potential causality between pain and neuropsychiatric disorders.
Results: Among the 169 pairwise pain and neuropsychiatric disorders, 55 pairs showed significant ( P < 1.54×10 −4 ) positive correlations (median r g = 0.43) and 9 pairs showed negative correlations (median r g = −0.31). MR analyses identified 26 significant ( P <1.48×10 −4 ) likely causal associations, for instance, neuroticism and insomnia were risk factors for most of short-term pain, multisite chronic pain was risk factor for neuroticism, insomnia, major depressive disorder and attention deficit/hyperactivity disorder, and vice versa. The signals of pain and neuropsychiatric disorders tended to be enriched in the functional regions of cell types from central nervous system (CNS). A total of 19 genes shared in at least one pain and neuropsychiatric disorder pair were identified by TWAS integrating the gene expression information of CNS. The shared genes included AMT , NCOA6 and UNC45A which involved in glycine degradation, insulin secretion and cell proliferation, respectively, suggesting pain and neuropsychiatric disorders might share neuronal signaling-related, metabolism-related and proliferation-related pathogenic mechanisms.
Conclusion: Our findings provided the evidence of shared genetic structure, causality and potential shared pathogenic mechanisms between pain and neuropsychiatric disorders, and enhanced our understanding of the comorbidities of pain and neuropsychiatric disorders.
Pharmacokinetic Evaluation of Tacrolimus in Chinese Adult Patients Receiving Voriconazole During the Early Stage Post-Lung Transplantation
Authors: Cui Yi-fan , Zhu Min-fang , Pan Yan , Jiao Zheng 
Published: September 2022

Abstract

Although tacrolimus has been widely used in patients undergoing lung transplantation, few studies have reported the pharmacokinetics of tacrolimus in Chinese patients after lung transplantation. Thus, we aimed to investigate its pharmacokinetics and influential factors in this patient cohort in the early stage after lung transplantation. We enrolled 14 lung transplant recipients who were treated with tacrolimus and voriconazole. We then collected intensive blood samples within a 12-hour dosing interval and analysed them via liquid chromatography-mass spectrometry. The pharmacokinetic parameters of tacrolimus were calculated using non-compartmental analysis, and the influence of physio-pathological characteristics and CYP3A5*3 and CYP3A4*1G genotypes on the pharmacokinetics of tacrolimus was assessed. Using linear regression analysis, we then investigated the correlation between tacrolimus concentration at different sampling points and measured the area under the curve (AUC0 − 12h). Our results showed a mean apparent clearance (CL/F) rate of 14.2 ± 11.0 L/h, with CYP3A5*1 carriers having a CL/F rate five times higher than non-carriers (P < 0.001). Furthermore, tacrolimus concentration 4 h after the administration had the strongest correlation with AUC0 − 12h (R2 = 0.979). In summary, tacrolimus pharmacokinetics varied largely between patients during the early-stage post-lung transplantation, which could be partly explained by CYP3A5 genetic polymorphisms. Therefore, it is crucial to closely monitor tacrolimus blood concentration in the early stages after lung transplantation.
Drug release kinetics of artemisinin sustained-release granules with two sizes for algal inhibition in different media
Authors: Xu Chu , Ni Lixiao , Wizi Jakpa , Du Cunhao , Jiang Zhiyun , Sang Wenlu , Li Shiyin , Chen Xuqing , Su Hua , Xu Jian 
Published: September 2022

Abstract
To avoid the disadvantage that artemisinin granules coated with millimeter level chitosan alginate are easy to settle and improve the dispersion of granules in water, improved artemisinin sustained release granules (ASGs) were prepared by ultrasonic technology combined with ion crosslinking method in this study. The release kinetics of two kinds of granules under different media conditions (temperature, ionic strength, pH, algal liquid, and Taihu Lake water) were studied. The physicochemical characterization showed that the diameter and zeta potential of the improved ASGs were 1189.5nm and -38.0mV, respectively. Here, the drug release of chitosan-coated artemisinin alginate granules is affected by the temperature, pH, and ionic strength of the release medium. Whether ASGs or improved ASGs, drug release increased with the increase of temperature and ionic strength, but decreased with the increase of pH. More importantly, the release kinetics study showed that the release mechanism of the improved ASGs in Taihu Lake water and algae liquid is matrix dissolution, while the release of ASGs in Taihu Lake water was controlled by diffusion and skeleton dissolution. The growth experiment of cyanobacteria showed that the improved ASGs have a long-term inhibitory effect on algae cells, and the inhibitory effect on cyanobacteria increased with the increase of dosing concentration. Our study clearly shows that the granules with reduced diameter have the characteristics of rapid dispersion and continuous release, and have the potential to be applied to the control of cyanobacteria bloom.
A Novel Approach Toward the Prevention of the Side Channel Attacks for Enhancing the Network Security
Authors: Gupta Suchismita , Sarkar Bikramjit , Saha Subhrajyoti , Sarkar Indranath , Chakrabarti Prasun , Sahana Sudipta , Chakrabarti Tulika , Elngar Ahmed A. 
Published: September 2022

Abstract
Privacy protection is an essential section of information security. The use of shared resources demands more privacy and security protection, especially in cloud computing environments. The aim of side-channel attacks is to extract secrets from systems. This can be through measurement and analysis of physical parameters. Execution time, electromagnetic emission, and supply current are some examples of such parameters. A side-channel attack does not target a program or its code directly. Instead, a side-channel attack attempts to gather information or influence the program execution of a system by measuring or exploiting the indirect effects of the system or its hardware. Put simply, a side-channel attack breaks cryptography by exploiting information inadvertently leaked by a system. The modules with integrated cryptographic systems pose a serious threat to these attacks. It has been observed that many robust algorithmic cryptographic operations have been broken successfully by side-channel analysis techniques. In this paper, the aim is to present a comparative review of the various side channel attacks possible and their countermeasures. Also, a new approach is proposed to prevent side-channel attacks and enhance the security of the entire network. The primary objective of this survey is to provide researchers in the field of side-channel attack a comprehensive summary of the progress achieved so far and to facilitate them to identify a few challenging future research areas.
Design of High Performance DP-RCNN Architecture for Wild Animal and Vehicle Detection
Authors: Krishnan Ramesh , ANDAVAN Mohanaprakash THOTIPALAYAM , G Senthilkumar , Balaji  
Published: September 2022

Abstract
Detection and recognition of object is challenging task nowadays in the computer vision domain. To solve this problem, many objects detection technique introduced but it is very difficult for automation of object detection, in natural environment. In forest areas, Wild animal and vehicle detection is a dynamic research field since the last several decades. Novel DP-RCNN architecture has proposed in this paper, by combining detecting and classifying task in a single neural network. It is based on generating proposals by SPP layer and features extraction from proposals to train the network which provide high classified output. The network was trained by animal and vehicle dataset which are selected from COCO dataset with their labels respectively for different animal classes. Based on these stored datasets, the video frame has processed and classified using DP-RCNN method. This experiment is conducted to access the following qualities, say, to verify whether the system is able to detect the object and to measure the accuracy of the proposed system. Implementation result shows that proposed DP-RCNN improves accuracy and recall by 94.59 %, 0.97. Precision and recognition rate of proposed method also achieved by 0.95, 73.4% when compared with existing scheme.
Medical Image to Image Translation using Multi Label Activated Gradients for General Adversial Networks ((MLAG GAN))
Authors: M Raja , S Vijayachitra 
Published: September 2022

Abstract
Multi modal MRI provides complementary and clinically relevant information from the image to understand the condition of the tissue and to characterize various complex diseases. But imaging artifacts influence the determination of relevant inforamtion from brain metastatis which is difficult to obtain adequate number of modalities from same study subject because of the under optimized study plan. However quantitative analysis becomes mandatory for in-depth understanding of the disease. Existing works could not exploit and maintain texture details from the scanners. In this research work, it is designed a multi label activated gradients for GAN (MLAG GAN) to enrich the corresponding reconstruction images with huge information. The detailed study trained the developed model by permitting the gradient flow from multiple gradients to a single generator at multiple labels thereby addressing the prevailing limitaiton of GAN. This system could exploit multi label neural transfer that enable to grasp more number of semantic and lesion related priors from the reference images. It is also validated the proposed system on Flair T1 and Flair T2 from Brats 18 dataset that depicts superior performance on the quality of image generation when compared to the state of art methods. The multi label GAN regenerates more high resolution structure and texture information and the wide range of qualitative and quantitative comparative experiments with the state of art methods proves the effectiveness of the proposed system in terms of L1, MSE (Mean square error), PSNR (Peak to signal ratio),SSIM (Structure similarity index measure), and Inception Score( IS).
Relationships between Water Translocation and Zinc Accumulation in Citrus Trees with and without Blight1
Authors: Young R. H. , Wutscher H. K. , Albrigo L. G. 
Published: September 2022

Abstract
Orange trees (Citrus sinensis (L.) Osb.) with early-stage (sectored) and moderate blight were evaluated for zinc accumulation and water translocation characteristics. Zinc accumulated at above-normal levels in the outer 2 cm of trunk wood, but water uptake was at below-normal levels in the inner 2 to 6 cm of trunk wood of moderately blighted trees. Water-flux density of roots was not correlated with zinc accumulation. In trees with early stages of blight, zinc accumulated at above-normal levels in the healthy-appearing sides of the trunks, as well as in the blighted sides, but the water uptake in the healthy-appearing sides was similar to that in the trunks of healthy trees. Evidence suggested that the blight effect on abnormal zinc metabolism developed prior to the dysfunction of water translocation.