bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sinonasal Squamous Cell Carcinoma Survival Outcomes Following Induction Chemotherapy vs Standard of Care Therapy
Authors: Murr Alexander T. , Lenze Nicholas R. , Weiss Jared M. , Grilley‐Olson Juneko E. , Patel Shetal A. , Shen Colette , Chera Bhishamjit S. , Zanation Adam M. , Thorp Brian D. , Sheth Siddharth H. 
Published: March 2022

ObjectiveTo compare oncologic outcomes in sinonasal squamous cell carcinoma (SNSCC) treated with standard of care (SOC) definitive therapy, consisting of surgery or chemoradiotherapy, vs induction therapy followed by definitive therapy.Study DesignRetrospective review.SettingAcademic tertiary care hospital.MethodsThe medical records of patients with biopsy‐proven SNSCC treated between 2000 and 2020 were reviewed for demographics, tumor characteristics, staging, treatment details, and oncologic outcomes. Patients were matched 1‐to‐1 by age, sex, and cancer stage according to treatment received. Time‐to‐event analyses were conducted.ResultsThe analysis included 26 patients with locally advanced SNSCC who received either induction therapy (n = 13) or SOC (n = 13). Baseline demographics, Charlson Comorbidity Index, and median follow‐up time were well balanced. Weekly cetuximab, carboplatin, and paclitaxel were the most common induction regimen utilized. Tolerance and safety to induction were excellent. Objective responses were observed in 11 of 13 patients receiving induction. No difference in disease‐free survival was found between the induction and SOC groups at 1 or 3 years. However, when compared with SOC, induction therapy resulted in significant improvement in overall survival at 2 years (100% vs 65.3%, P =. 043) and 3 years (100% vs 48.4%, P =. 016) following completion of definitive therapy. Two patients in the SOC group developed metastatic disease, as compared with none in the induction group.ConclusionsInduction therapy was safe and effective. When compared with SOC, induction therapy improved 3‐year overall survival.
Comparison of Caregiver‐ and Child‐Reported Quality of Life in Children With Sleep‐Disordered Breathing
Authors: Yu Phoebe Kuo , Cook Kaitlyn , Liu Jiayan , Amin Raouf S. , Derkay Craig , Elden Lisa M. , Garetz Susan L. , George Alisha S. , Ibrahim Sally , Ishman Stacey L. , Kirkham Erin M. , Naqvi S. Kamal , Radcliffe Jerilynn , Ross Kristie R. , Shah Gopi B. , Tapia Ignacio E. , Taylor H. Gerry , Zopf David A. , Redline Susan , Baldassari Cristina M. 
Published: March 2022

AbstractObjectiveCaregivers frequently report poor quality of life (QOL) in children with sleep‐disordered breathing (SDB). Our objective is to assess the correlation between caregiver‐ and child‐reported QOL in children with mild SDB and identify factors associated with differences between caregiver and child report.Study DesignAnalysis of baseline data from a multi‐institutional randomized trialSettingPediatric Adenotonsillectomy Trial for Snoring, where children with mild SDB (obstructive apnea‐hypopnea index <3) were randomized to observation or adenotonsillectomy.MethodsThe Pediatric Quality of Life Inventory (PedsQL) assessed baseline global QOL in participating children 5 to 12 years old and their caregivers. Caregiver and child scores were compared. Multivariable regression assessed whether clinical factors were associated with differences between caregiver and child report.ResultsPedsQL scores were available for 309 families (mean child age, 7.0 years). The mean caregiver‐reported PedsQL score was higher at 75.2 (indicating better QOL) than the mean child‐reported score of 67.9 (P < .001). The agreement between caregiver and child total PedsQL scores was poor, with intraclass correlation coefficients of 0.03 (95% CI, –0.09 to 0.15) for children 5 to 7 years old and 0.21 (95% CI, 0.03‐0.38) for children 8 to 12 years old. Higher child age and health literacy were associated with closer agreement between caregiver and child report.ConclusionCaregiver‐ and child‐reported global QOL in children with SDB was weakly correlated, more so for young children. In pediatric SDB, child‐perceived QOL may be poorer than that reported by caregivers. Further research is needed to assess whether similar trends exist for disease‐specific QOL metrics.
Examining Associations Between Neighborhood‐Level Social Vulnerability and Care for Children With Sleep‐Disordered Breathing
Authors: Yan Flora , Pearce John L. , Ford Marvella E. , Nietert Paul J. , Pecha Phayvanh P. 
Published: March 2022

ObjectiveWe aim to investigate the impact of neighborhood‐level social vulnerability on otolaryngology care for children with obstructive sleep‐disordered breathing (SDB).Study DesignRetrospective cohort study.SettingA tertiary children’s hospital.MethodsChildren aged 2 to 17 years with SDB were included. Residential addresses were geocoded with geographic information systems, and spatial overlays were used to assign census tract–level social vulnerability index (SVI) scores to each participant. Multivariable logistic regression models were used to estimate associations of neighborhood SVI scores and individual factors with attendance of otolaryngology referral appointment and interventions.ResultsThe study included 397 patients (mean ± SD age, 5.9 ± 3.7 years; 51% male, n = 203). After adjustment for age and sex, children with higher overall SVI scores (odds ratio [OR], 0.40; 95% CI, 0.16‐0.92) and higher socioeconomic vulnerability scores (OR, 0.34; 95% CI, 0.14‐0.86) were less likely to attend their referral appointments. The odds of attending referrals were 83% lower (OR, 0.17; 95% CI, 0.09‐0.34) for Black children and 73% lower (OR, 0.27; 95% CI, 0.11‐0.65) for Hispanic children than for non‐Hispanic White children. Medicaid beneficiaries had lower odds of attending their referrals (OR, 0.20; 95% CI, 0.08‐0.48) than privately insured children. Overall SVI score was not associated with receiving recommended polysomnography or tonsillectomy.ConclusionIn our study, children living in areas of greater social vulnerability were less likely to attend their otolaryngology referral appointments for SDB evaluation, as were children of Black race, Hispanic ethnicity, and Medicaid beneficiaries. These results suggest that neighborhood conditions, as well as patient‐level factors, influence patient access to SDB care.
Treatment of Opioid Use Disorder in Canadian Psychosocial Addiction Programs: A National Survey of Policy, Attitudes, and Practice
Authors: Hodgins David C. , Budd Mathew , Czukar Gail , Dubreucq Simon , Jackson Lois A. , Rush Brian , Quilty Lena C. , Adams Denise , Cameron Wild T. 
Published: March 2022

Objective To describe current approaches in treatment of opioid use disorder (OUD) within Canadian psychosocial outpatient, day, and residential addiction treatment programs, with an emphasis on the use of opioid agonist therapy (OAT). Method An online census survey was conducted in English and French of Canadian psychosocial addiction treatment programs ( N = 214). Results Programs estimated that 25% of their clients have OUD. A slight majority of programs provide some type of specialized services to clients with OUD (58%), most frequently providing or facilitating access to OAT but also specialized counselling, case management, education, and harm reduction services. Most programs reported that they admitted clients on OAT (88%) and only a minority expected or encouraged clients to taper (14%) or discontinue (6%). Programs focusing on client abstinence as the treatment goal were more likely to expect or encourage tapering or discontinuation than programs that focus on helping clients achieve personal consumption goals. Of programs that did not currently facilitate OAT, 44% indicated that they would provide OAT, but lacked the necessary accreditation, physician support, or other resources. No philosophical objections to OAT were noted. OAT initiation was provided by 30% of programs, 23% referred to another service within their organization, and 29% referred to a service outside their organization. The remaining 18% did not facilitate OAT initiation at all, ranging from 0% in Quebec to 23% in the Prairies. Overdose response kits were provided by 86% of programs. The majority not providing kits indicated willingness if policy support and resources were provided (67%). Conclusions Overall, the results demonstrate that psychosocial programs provide some specialized services for OUD but desire further support specifically to provide OAT, including training, knowledge, and the expertise of individuals qualified to prescribe and dispense OAT. Many psychosocial treatment programs expressed a need for staff and resources for this purpose.
A Path from Traditional Bullying to Cyberbullying in South Korea: Examining the Roles of Self-Control and Deviant Peer Association in the Different Forms of Bullying
Authors: Kim Jihoon , Lee Yeungjeom , Jennings Wesley G. 
Published: March 2022

Despite a recent growth in studies on cyberbullying, extant knowledge on the underlying mechanisms of cyberbullying remain limited. The objective of the present study is to explore the dynamics of cyberbullying via traditional bullying, self-control, and delinquent peer association. Specifically, the following hypotheses guide the present study: (1) traditional bullying, low self-control, and delinquent peer association are predictive of cyberbullying, respectively, (2) the interaction between traditional bullying and low self-control has a significant impact on cyberbullying, and (3) the interaction between traditional bullying and delinquent peer association has a significant impact on cyberbullying. The present study relies on five waves of the Korean Youth Panel Survey (KYPS), a representative sample of South Korean adolescents. Data collection occurred annually and respondents were 14 years old at the first wave in 2003. KYPS is an almost gender-equal and racially/ethnically homogenous sample. Results of cross-lagged dynamic panel models show (1) significant effects of traditional bullying on cyberbullying with and without low self-control and delinquent peer affiliation, (2) the respective roles of self-control and delinquent peer association in the prediction of cyberbullying, and (3) an interaction effect between low self-control and traditional bullying on cyberbullying. These findings demonstrate the theoretical validity of self-control theory and social learning theory in online delinquent behavior as well as confirm their cross-cultural generalizability in a non-Western sample. The findings also highlight the importance of investing in early life-course prevention/intervention programs and policies to prevent and/or reduce the occurrence of bullying, regardless of whether it is being perpetrated face-to-face or online, and these programs and policies should also target components to improve self-control and reduce delinquent peer associations.
Examining the Post-High School Effects of a Primary Prevention Program on Exposure to Bullying and Sexual Violence among Emerging Adults
Authors: Williford Anne , Yoder Jamie , Sharp Julia , Tunstall Ashley , Espelage Dorothy L , Ortega Lilyana , Fulginiti Anthony 
Published: March 2022

Emerging adulthood (EA) is a time of self-exploration as new opportunities for independence and autonomy arise. Yet, for some youth, this may also contribute to instability, uncertainty, and anxiety. Consequently, evidence suggests that rates of exposure to various forms of violence increase in EA. This study examined changes in experiences of bullying and sexual violence (SV) victimization among a sample of post-high school emerging adults who were exposed to a primary prevention program, Sources of Strength ( Sources). We also examined whether Sources skills (e.g., healthy coping and help-seeking) buffer against these experiences. Participants were 102 emerging adults (73.5% identifying as female, 36.3% as Latinx, and 22.6% as LGBQ), who completed surveys at three time points: 1 month prior to graduation and at 6- and 12-months post-graduation. Results suggest that as youth transition into emerging adulthood, experiences of bullying victimization were relatively low and slightly decreased whereas experiences of SV were also relatively low, but stable over time. Notably, bullying victimization was lower when female-identifying participants, relative to males, had higher levels of healthy coping. In addition, SV victimization for participants identifying as non-white was higher at lower levels of coping than those identifying as white; however, at higher levels of coping, non-white participants reported lower rates of SV victimization, while rates were relatively stable for white participants at high and low levels of coping. These findings provide some support for the Sources program model where engaging in healthy coping may protect young women from bullying exposure and buffer against SV victimization for racial and ethnic minoritized young adults. Implications for violence prevention are discussed.
Effectiveness of a Digital Intervention in Increasing Flu Vaccination–Related Risk Appraisal, Intention to Vaccinate and Vaccination Behaviour Among Pregnant Women
Authors: Parsons Joanne , Grimley Catherine , Newby Katie 
Published: March 2022

Background Pregnant women are at increased risk of complications from flu, but uptake of flu vaccination is below 75% targets. Evidence suggests that changing illness risk appraisals may increase vaccination behaviour. In 2018–2019, researchers, public health specialists, and pregnant women co-designed a short animation targeting (unhelpful) beliefs underlying pregnant women’s flu risk appraisals aiming to promote vaccination uptake. Aims This study aimed to examine effectiveness of a digital intervention (animation) in increasing flu vaccination among pregnant women through changing illness risk appraisals. Method A prospective study design was used, involving convenience sampling of unvaccinated pregnant women recruited via a Qualtrics Online Panel. Participants received small payments via the panel for survey completion. Risk appraisals and intention to vaccinate were measured at baseline and immediately after intervention presentation (follow-up one). Six months later, a further survey (follow-up two) was administered measuring vaccination behaviour. Results Baseline and first follow-up surveys were completed by 411 participants. Watching the animation led to increased appraisals of likelihood of getting flu while pregnant and severity of flu during pregnancy, and increased intentions to accept flu vaccination during pregnancy. Of the 67 respondents who completed follow-up survey two, 38 reported having the vaccination while pregnant. Conclusions This study provides evidence supporting the promise of the intervention. Randomized controlled trials are required to produce definitive efficacy evidence. Should such a study prove intervention effectiveness, it could be readily embedded within existing campaigns at national and local levels by public health organizations.
L-Acetylcarnitine causes analgesia in mice modeling Fabry disease by up-regulating type-2 metabotropic glutamate receptors
Authors: Formaggio Francesco , Rimondini Roberto , Delprete Cecilia , Scalia Leonardo , Merlo Pich Emilio , Liguori Rocco , Nicoletti Ferdinando , Caprini Marco 
Published: March 2022

Fabry disease (FD) is a X-linked lysosomal storage disorder caused by deficient function of the alpha-galactosidase A (α-GalA) enzyme. α-GalA deficiency leads to multisystemic clinical manifestations caused by the preferential accumulation of globotriaosylceramide (Gb3). A hallmark symptom of FD patients is neuropathic pain that appears in the early stage of the disease as a result of peripheral small fiber damage. Previous studies have shown that Acetyl-L-carnitine (ALC) has neuroprotective, neurotrophic, and analgesic activity in animal models of neuropathic pain. To study the action of ALC on neuropathic pain associated with FD, we treated α-GalA gene null mice (α-GalA(-/0)) with ALC for 30 days. In α-Gal KO mice, ALC treatment induced acute and long-lasting analgesia, which persisted 1 month after drug withdrawal. This effect was antagonized by single administration of LY341495, an orthosteric antagonist of mGlu2/3 metabotropic glutamate receptors. We also found an up-regulation of mGlu2 receptors in cultured DRG neurons isolated from 30-day ALC-treated α-GalA KO mice. However, the up-regulation of mGlu2 receptors was no longer present in DRG neurons isolated 30 days after the end of treatment. Taken together, these findings suggest that ALC induces analgesia in an animal model of FD by up-regulating mGlu2 receptors, and that analgesia is maintained by additional mechanisms after ALC withdrawal. ALC might represent a valuable pharmacological strategy to reduce pain in FD patients.
TMEM43 promotes pancreatic cancer progression by stabilizing PRPF3 and regulating RAP2B/ERK axis
Authors: Li Junqiang , Song Yang , Zhang Chao , Wang Ronglin , Hua Lei , Guo Yongdong , Gan Dongxue , Zhu Liaoliao , Li Shanshan , Ma Peixiang , Yang Cheng , Li Hong , Yang Jing , Shi Jingjie , Liu Xiaonan , Su Haichuan 
Published: March 2022

AbstractBackgroundTransmembrane protein 43 (TMEM43), a member of the transmembrane protein subfamily, plays a critical role in the initiation and development of cancers. However, little is known concerning the biological function and molecular mechanisms of TMEM43 in pancreatic cancer.MethodsIn this study, TMEM43 expression levels were analyzed in pancreatic cancer samples compared with control samples. The relationship of TMEM43 expression and disease-free survival (DFS) and overall survival (OS) were assessed in pancreatic cancer patients. In vitro and in vivo assays were performed to explore the function and role of TMEM43 in pancreatic cancer. Coimmunoprecipitation (co-IP) followed by protein mass spectrometry was applied to analyze the molecular mechanisms of TMEM43 in pancreatic cancer.ResultsWe demonstrated that TMEM43 expression level is elevated in pancreatic cancer samples compared with control group, and is correlated with poor DFS and OS in pancreatic cancer patients. Knockdown of TMEM43 inhibited pancreatic cancer progression in vitro, decreased the percentage of S phase, and inhibited the tumorigenicity of pancreatic cancer in vivo. Moreover, we demonstrated that TMEM43 promoted pancreatic cancer progression by stabilizing PRPF3 and regulating the RAP2B/ERK axis.ConclusionsThe present study suggests that TMEM43 contributes to pancreatic cancer progression through the PRPF3/RAP2B/ERK axis, and might be a novel therapeutic target for pancreatic cancer.
MiR-5195-3p functions as a tumor suppressor in prostate cancer via targeting CCNL1
Authors: Zeng Xing , Hu Zhiquan , Shen Yuanqing , Wei Xian , Gan Jiahua , Liu Zheng 
Published: March 2022

Abstract
Background
Accumulating evidence indicates that miR-5195-3p exerts tumor-suppressive roles in several tumors. However, the clinical significance and biological function of miR-5195-3p in prostate cancer (PCa) have not been reported yet.

Methods
The expression levels of miR-5195-3p and Cyclin L1 (CCNL1) were determined using quantitative real-time PCR in clinical specimens and cell lines. The clinical significance of miR-5195-3p in patients with PCa was evaluated using Kaplan–Meier survival analysis and Cox regression models. Cell proliferation and cell cycle distribution were measured by CCK-8 assay and flow cytometry, respectively. The association between miR-5195-3p and CCNL1 was analyzed by luciferase reporter assay.

Results
MiR-5195-3p expression levels were significantly downregulated in 69 paired PCa tissues compared with matched adjacent normal tissues. The decreased miR-5195-3p expression was associated with Gleason score and TNM stage, as well as worse survival prognosis. The in vitro experiments showed that miR-5195-3p overexpression suppressed the proliferation and cell cycle G1/S transition in PC-3 and DU145 cells. Elevated miR-5195-3p abundance obviously impaired tumor formation in vivo using PC-3 xenografts. Mechanistically, CCNL1 was a direct target of miR-5195-3p in PCa cells, which was inversely correlated with miR-5195-3p in PCa tissues. Importantly, CCNL1 knockdown imitated, while overexpression reversed, the effects of miR-5195-3p overexpression on PCa cell proliferation and cell cycle G1/S transition.

Conclusions
Our data suggest that miR-5195-3p functions as a tumor suppressor by targeting CCNL1 in PCa.
Synthesis of typical sulfonamide antibiotics with [14C]- and [13C]-labeling on the phenyl ring for use in environmental studies
Authors: Wu Xuan , Yao Yao , Wang Lianhong , Zhou Dashun , Sun Feifei , Chen Jianqiu , Corvini Philippe Francois-Xavier , Ji Rong 
Published: March 2022

Abstract
Background
Due to their widespread use, sulfonamide antibiotics (SAs) have become ubiquitous environmental contaminants and thus a cause of public concern. However, a complete understanding of the behavior of these pollutants in complex environmental systems has been hampered by the unavailability and high cost of isotopically labeled SAs.

Results
Using commercially available uniformly [14C]- and [13C]-labeled aniline as starting materials, we synthesized [phenyl-ring-14C]- and [phenyl-ring-13C]-labeled sulfamethoxazole (SMX), sulfamonomethoxine (SMM), and sulfadiazine (SDZ) in four-step (via the condensation of labeled N-acetylsulfanilyl chloride and aminoheterocycles) or five-step (via the condensation of labeled N-acetylsulfonamide and chloroheterocycles) reactions, with good yields (5.0–22.5% and 28.1–54.1% for [14C]- and [13C]-labeled SAs, respectively) and high purities (> 98.0%).

Conclusion
The synthesis of [14C]-labeled SAs in milligram amounts enables the preparation of labeled SAs with high specific radioactivity. The efficient and feasible methods described herein can be applied to the production of a variety of [14C]- or [13C]-labeled SAs for studies on their environmental behavior, including the fate, transformation, and bioaccumulation of these antibiotics in soils and aqueous systems.