bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indicators of the dimensions of trust (and mistrust) in early primary care practice: A qualitative study
Authors: Zgurzynski Mary , O'Reilly-Jacob Monica , Duggan Ashley P. , Vicini Andrea , Shaughnessy Allen 
Published: November 2022

Abstract
Background
Trust occurs when a person feels they can be vulnerable to others because of the sincerity, benevolence, truthfulness and sometimes the competence they perceive. This project examines the various types of trust expressed in written reflections of developing healthcare clinicians. Our goal is to understand the roles trust plays in residents’ self-examination and to offer insight from relationship science to inform the teaching and clinical work for better trust in healthcare.
Methods
We analyzed 767 reflective writings of 33 residents submitted anonymously, to identify explicit or implicit indicators attention to trust or relationship development. Two authors independently coded the entries based on inductively identified dimensions. Three authors developed a final coding structure that was checked against the entries. These codes were sorted into final dimensions.
Results
We identified 114 written reflections that contained one or more indicators of trust. These codes were compiled into five code categories: Trust of self/trust as the basis for confidence in decision making; Trust of others in the medical community; Trust of the patient and its effect on clinician; Assessment of the trust of them exhibited by the patient; and Assessment of the effect of the patient’s trust on the patient’s behavior.
Discussion
Broadly, trust is both relationship-centered and institutionally situated. Trust is a process, built on reciprocity. There is tacit acknowledgement of the interplay among what the residents do is good for the patient, good for themselves, and good for the medical institution. A focus on moments in which trust is experienced or missed, as well as on types of trust, misses this complexity.
Conclusion
A greater awareness of how trust is present or absent could lead to a greater understanding and healthcare education for beneficial effects on clinicians’ performance, personal and professional satisfaction, and improved quality in patients’ interactions.
Comparison of CT values in traditional trajectory, traditional cortical bone trajectory, and modified cortical bone trajectory
Authors: Liu Dongshan , Kahaer Alafate , Wang Yixi , Zhang Rui , Maiaiti Abulikemu , Maimaiti Xieraili , Zhou Zhihao , Shi Wenjie , Cui Zihao , Zhang Tao , Li Longfei , Rexiti Paerhati 
Published: November 2022

Abstract
Background: To compare the CT values and length of the screw tracks of traditional trajectory (TT), cortical bone trajectory (CBT), and modified cortical bone trajectory (MCBT) screws and investigate the effects on the biomechanics of lumbar fixation.
Methods: CT scan data of 60 L4 and L5 lumbar spine were retrieved and divided into 4 groups (10 male and 10 female cases in the 20-30 years old group and 20 male and 20 female cases in the 30-40 years old group). 3-dimentional (3D) model were established using Mimics 19.0 for each group and the placement of three techniques was simulated on the L4 and L5, and the part of the bone occupied by the screw track was set as the region of interest (ROI). The mean CT value and the actual length of the screw track were measured by Mimics 19.0.
Results: The CT values of ROI for the three techniques were significantly different between the same gander in each age group (P＜0.05). The difference of screw track lengths for CBT and MCBT in the male and female is significant (P＜0.05). Conclusions: According to the CT values of the three screw tracks: MCBT > CBT > TT, the MCBT screw track has greater bone-screw surface strength and longer screw tracks than CBT, which is easier to reach the anterior column of the vertebral body contributing to superior biomechanical properties.
Daily work variability in falls prevention of hospitalized patients: Nursing team’s perception
Authors: de QUADROS Deise Vacario , WACHS Priscila , de MAGALHÃES Ana Maria Müller , SEVERO Isis Marques , TAVARES Juliana Petri , PAI Daiane DAL 
Published: November 2022

Abstract
Background: the identification of safety incidents and establishment of systematic methodologies in health services to reduce risks and provide quality care was implemented by The World Health Organization. These safety incidents allowed the visualization of a wide panorama, ranging from preventable incidents to adverse events with catastrophic outcomes for patients. In this scenario, the issue of fall(s) is inserted, which, despite being a preventable event, can lead to several consequences for the patient, family and the healthcare system, being the second cause of death by accidental injury worldwide, this study aims to identify the variability inherent in the daily work in fall prevention, the strategies used by professionals to deal with it and the opportunities for improvement of the management of work-as-imagined.
Design: an exploratory and descriptive study, of qualitative approach, through process modeling and semi-structured interviews.
Methods: was conducted in a public university hospital in southern Brazil, following four steps: modeling of the prescribed work; identification of falls; modeling of the daily work and reflections on the gap between work-as-done and work-as-imagined. Medical records, management reports, notification records, protocols, and care procedures were consulted for modeling the work process and semi-structured interviews were conducted with 21 Nursing professionals. The study was conducted between March 2019 and December 2020.
Findings: from July 2018 to July 2019, 447 falls occurred, 2.7% with moderate to severe injury. The variability occurred in the orientation of the companion and in the assurance of the accompanied patient's de-ambulation. The professionals identified individual strategies to prevent falls, the importance of multi-professional work, learning with the work team, the colleague’s expertise, as well as suggesting improvements in the physical environment.
Conclusion: this study addressed the need for fall prevention in the hospital setting as one of the main adverse events that affect patients. The identification of the variability inherent to the work allows professionals to identify opportunities for improvement, understand the risks to which patients are subjected and develop the perception of fall risk as a way to reduce the gap between work-as-imagined and work-as-done.
Information Use, Seeking Behaviors, and Barriers to Evidence-Based Information at a Large Teaching Hospital in the UK
Authors: Lagojda Lukasz , O'Connell Bridget , Brown Anna , Dekker Natasha S. den 
Published: November 2022

Abstract
Background: To better understand the needs of service users, this study explored the information use and the factors affecting access to evidence-based information by clinicians in a primary care setting.
Methods: An online survey was distributed to all staff via SurveyMonkey®. Data were curated in Microsoft Excel and managed using SPSS v26. Graphs were generated using GraphPad PRIMS.
Results: Ninety-three per cent of the surveyed clinicians used evidence-based information in practice, primarily for patient care and education. Clinicians employed a range of seeking behaviors to retrieve this information, which varied based on how often this information was needed. The barriers to evidence-based information varied between clinical professions but ‘time’ was the most consistent factor. The belief of evidence-based practice being not part of the job role was the overwhelming factor for not using evidence-based information.
Conclusions: The findings of this study are consistent with previous reports describing significant impact of time and access to IT resources on whether search for evidence-based information and provided us with useful insights for improving our services.
Cd uptake mechanisms by hyperaccumulator Bidens pilosa L. roots under different salinity and pH levels
Authors: Wang Siqi , Dai Huiping , Cui Shuang , Ji Dandan , Skuza Lidia , Li Lianzhen , Grzebelus Dariusz , Wei Shuhe 
Published: November 2022

Abstract
Bidens pilosa L. has been confirmed to be a potential Cd hyperaccumulator by some researchers, but the dynamic and real-time uptake of Cd2+ influx by B. pilosa root apexes was a conundrum up to now. The aim of our study was to investigate the effects of salinity and pH variations on the characteristics of Cd2+ influx around the root apexes of B. pilosa. The tested seedlings of B. pilosa were obtained by sand culture experiments in a greenhouse after one month from germination, and the Cd2+ influxes from the root apex of B. pilosa under Cd treatments with different salinity and pH levels were determined with application of non-invasive micro-test technology (NMT). The results showed that Cd2+ influxes at 300 µm from the root tips decreased under Cd treatments with 5 mM and 10 mM NaCl, as compared to Cd stress alone. However, Cd treatments with 2.5 mM NaCl had little effect on the net Cd2+ influxes, as compared to Cd treatments alone. Importantly, Cd treatments at pH = 4.0 markedly increased Cd2+ influxes in roots, and Cd treatment at pH = 7.0 had no significant effect on the net Cd2+ influxes with compared to Cd treatments at pH = 5.5. Results also showed that Cd treatments with 10 mM NaCl significantly decreased concentrations of chlorophyll (Chl) a and b in leaves and root vigor of B. pilosa relative to Cd treatments alone, while there were no significant differences between Cd treatments with 2.5 mM NaCl and Cd treatments alone. But root vigor was inhibited significantly under Cd treatments with 5 mM and 10 mM NaCl. A significant increase of root vigor was observed in Cd treatments at pH = 4.0, as compared to pH = 5.5. The Cd treatments with high and medium concentrations of NaCl inhibited the uptake of Cd by B. pilosa roots, and affected the Chl and root vigor further. But the Cd treatments at pH = 4.0 could promote the Cd uptake and root vigor. Our results revealed the uptake mechanisms of B. pilosa as a potential phytoremediator under different salinity and pH levels combined with Cd contamination, and provided a new idea for screening ideal hyperaccumulator and constructing evaluation system.
Probing the binding nature and stability of highly transmissible mutated variant Alpha to Omicron of SARS-CoV-2 RBD with ACE2 via molecular dynamics simulation
Authors: Ramakrishnan Jaganathan , Chinnamadhu Archana , Suresh Suganya , Poomani Kumaradhas 
Published: November 2022

Abstract
As of now there is no approved drug available as a causative agent of COVID-19. To resolve this issue, quickly identify a repurposed drug and develop new vaccines are the most promising solutions as it is the time-consuming process to design a new drug. As a therapeutic development, some vaccines and some repurposed drugs were approved to prevent people from SARS-CoV-2 infections during this pandemic period; all these medicines are made available based on the first structure of SARS-CoV-2 reported in late 2019 from Wuhan, China. Since then, vividly it is known that due to serious mutations in this virus, often its structure has been modified and emerged as the new types of variants; evidently, the new variants are the most dangerous and spreading very fast. SARS-CoV-2 variants are becoming the significant challenge to the current pandemic situation. Hence, the detailed structure of these variants is necessary to design new drugs and vaccines to inhibit the mutated SARS-CoV-2 variants. Present study analyzed the binding mode of receptor binding domain (RBD) of SARS-CoV-2 with the human angiotensin converting enzyme 2 (ACE2) using molecular dynamics simulation up to 500 ns. Notably, in some variants found an unusual binding mode of RBD with ACE2 forming different interactions; this was confirmed from the comparison of interaction between RBD-ACE2 of all variants with the wild type structure. Binding free energy values confirm that they exhibit high binding affinity towards ACE2. From this analysis, it is confirmed that the variations in the sequence of SARS-CoV-2 spike protein altered the binding mode which led to the high transmissibility caused new infections. This in-silico study on mutated variants alpha to omicron of SARS-CoV-2 RBD with ACE2 insights their binding mode, binding affinity and stability. This information is useful to design potential drug and vaccine to cure the devastating disease COVID-19.
Dysmenorrhea, intermenstrual bleeding, and irregularities post COVID-19 vaccination and associated factors: a retrospective observational study
Authors: Khan Ghadeer , Althubaiti Alaa , Al-Shrif Amal , Alsayed Zahra , Jifree Hatim 
Published: November 2022

Abstract

Background
coronavirus SARS-CoV-2 disease 2019 (COVID-19) vaccines have provided a fertile ground for research, especially with the unprecedented misinformation spread. One of the most reported side effects of the vaccine among women has been menstrual disturbances. In this paper, we aim to investigate the extent of the COVID-19 vaccine effects on the menstrual cycle as well as identify the associated factors that predispose an individual to dysmenorrhea, intermenstrual bleeding, change in flow volume, or irregularity post vaccine.
Methods
Any woman of menstruating age who received at least one dose of the COVID-19 vaccine and currently resides in Saudi Arabia was invited to complete an online questionnaire. The questionnaire compared menstruation characteristics—regularity, volume, intermenstrual bleeding, and dysmenorrhea—before receiving the COVID-19 vaccine with after, taking into consideration possible predisposing factors such as polycystic ovarian syndrome (PCOS), contraceptives, or period blocking pills.
Results
Women without PCOS experienced less changes in dysmenorrhea post COVID-19 vaccine compared to those with PCOS (23.88% vs 27.78% p-value = 0.045). Women using contraceptives were about two times more likely to experience volume changes compared to those not using contraceptives (OR = 2.09, 95%CI 1.23–3.57, p-value = 0.006). COVID-19 vaccine skeptics were about three times more likely to perceive changes in regularity post vaccine compared to non-skeptics (OR = 2.96, 95%CI, 1.79–4.90, p-value < 0.001). They were, also, 3 times more likely to perceive changes in volume post vaccine (OR = 3.04, 95%CI = 1.95–4.74, p-value < 0.001).
Conclusion
COVID-19 vaccine skepticism has a significant association with perceived post vaccine menstrual disturbances. Therefore, public education is crucial to combat the spread of misinformation and controversy surrounding the vaccines.
Who are the older adults' users or non-users of the Internet before the pandemic? Analysis of the EpiFloripa Ageing Cohort Study (2009-2019)
Authors: Quialheiro Anna , Rech Cassiano Ricardo , Silvestre Michelli , Boing Antonio Fernando , d´Orsi Eleonora 
Published: November 2022

Abstract
This ageing demographic transformation has been happening simultaneously with technological immersion, especially internet use in communication and health monitoring applications. This study's primary aim was to characterize the Internet's socioeconomic and demographic factors of internet users and non-users. The second aim was to analyze which factor, modifiable or not, influenced the incidence of older adults' Internet use over time. This study was done with 722 EpiFloripa Ageing Cohort Study follow-up of older adults. The outcome is internet use according to waves 1 to 3, and the exposures are sociodemographic. It described the characteristics of internet users and non-users, and it used a longitudinal analysis model (Generalized Estimating Equations) to estimate incidence rate ratios (IRR) with 95% confidence intervals. Internet users were younger, with higher education and higher income than non-users over time. Most non-users of the Internet were women (54%) and white (93%), with an average of 66.4 years old and 14 years of study. The incidence of internet use was 11,4% in Wave 2 and 23.0% in Wave 3 and was 80% lower in older adults 80 years and over compared to other age groups. Regarding schooling and family income, the internet use incidence was higher according to the increase in education levels and income range, except for older adults with more than 10 Brazilian minimum wage. Public policies are needed to reduce inequalities in access to the Internet and promote the digital inclusion of older adults.
Effect of PCL nanofiber mats coated with chitosan microcapsules containing cinnamon essential oil for wound healing
Authors: Osanloo Mahmoud , Noori Fariba , Tavassoli Alireza , Ataollahi Mohammad reza , Davoodi Ali , Seifalah-Zade Morteza , goodarzi Arash , Fereydouni Narges 
Published: November 2022

Abstract
Introduction: Cinnamon is one of the most common spices that have been studied for its anti-inflammatory, antioxidant, and antibacterial properties in wound healing. The purpose of this study was to evaluate the effectiveness of polycaprolactone nanofiber mats coated with chitosan microcapsules loaded with cinnamon essential oil on wound healing.
Material and methods: For this purpose, chitosan microcapsules containing cinnamon essential oil (µCS-CiZ) were prepared by ion gelation and PCL nanofibers by electrospinning. The size of the µCS-CiZ and the morphology of nanofibers were evaluated by DLS and FESEM methods. In order to evaluate wound healing, 48 rats in 4 groups of control, µCS-CiZ, nanofibers, and nanofibers coated with µCS-CiZ (PCL+µCS-CiZ) were examined on days 7, 14, and 21 in terms of macroscopy (wound closure rate) and histology (edema, inflammation, vascularity, fibrotic tissue, and re-epithelialization).
Results: The particle size of the µCS-CiZ and the diameter of the nanofibers were estimated at about 6.33±1.27 μm and 228 ± 33 nm, respectively. On day 21, both µCS-CiZ and PCL groups showed a significant decrease in wound size compared to the control group (p<0.001). The PCL+µCS-CiZ group also showed a significant decrease compared to the µCS-CiZ (p<0.05) and PCL groups (p<0.05). Histological results showed further reduction of edema, inflammation, and vascularity in granulation tissue, and appearance of moderate to marked fibrotic tissue in PCL+µCS-CiZ group compared with the other groups.
Conclusion: The results of the study showed that the combined use of PCL+µCS-CiZ indicates a synergistic effect in improving wound healing.
Correlative Analysis among AHP-based Scenic Beauty Estimation and Water Quality Indicators of 2 Typical Urban Constructed WQT Wetlands
Authors: Huang Yan , Li Tianjie , Jin Yang , Wu Wenting 
Published: November 2022

Abstract
Urban constructed water quality treatment (WQT) wetlands are often designed for removing pollutants, i.e., DO, CODCr, NH3-N, and TP. The water environment of WQT wetland waterscapes is strongly related to water quality, while scenic beauty values help achieve better water environments. To reveal correlations between several water quality indicators (WQIs) and scenic beauty indexes (SBIs), an AHP-based scenic beauty estimation (SBE) per site in 2 constructed WQT wetlands has been developed in the research. The weights of indicators are determined by the AHP voting method, which includes 3 main criteria, i.e., conditions of vegetation, physical geographic conditions, and human geographic conditions. SBIs are calculated by voting by judges from professional and unprofessional groups. WQIs of pollutants were sampled in situ during the field research simultaneously. Relationships among SBIs and WQIs are indicated by correlative analysis and a linear regression model with multiple variables. Applications for WQT wetland landscaping should be conducted on quantitative estimations in 3 aspects, i.e., follow strategies of ecological landscaping, improve water quality treatment techniques, and apply attention restoration theory. With deeper comprehension of SBIs, practical design, management, and maintenance of urban constructed WQT wetlands will be optimised.
Compression-Based Cancelable Multi-Biometric System
Authors: Elshazly Emad A. , Hashad Fatma G. , Sedik Ahmed , El-Samie Fathi E. Abd , Abdel-Salam Nariman 
Published: November 2022

Abstract

The issue of cybersecurity is one of the important fields which is involved in different research trends. Biometric security is one of these trends which is involved in several applications such as access control systems and online identity verification. The protection of human biometrics can be performed using both bi-directional and unidirectional encryption. The unidirectional encryption is carried out based on cancelable biometric techniques. This paper proposes a cancelable biometric system based on image composition, deep dream, and hashing techniques. The objective of the proposed system is to generate visual and text cancelable biometrics. The visual cancelable templates are generated using image composition and deep dream, while the text templates are generated using SHA hashing techniques. The proposed system is validated by multi-biometric inputs including iris, palm, face, and fingerprint biometrics. In addition, it is evaluated in both visual and text forms. The simulation results reveal that the proposed system appears a superior performance among the works which handle this problem.
Profiling of Driver Mutations Identified Rare Compound Mutations Sensitive to Second-generation EGFR-TKI in Lung Adenocarcinoma Patients
Authors: Li Jun , Zhang Cuiyun , Guan Yuping , Zheng Jiawen , Feng Junnan , Han Sile , Ma Ruijuan , Ren Pengfei , Li Shasha , Li Yi , Groen Harry J. M. , Kok Klaas , Berg Anke van den , Wei Bing , Ma Jie , Guo Yongjun , Li Hongle 
Published: November 2022

Abstract
Background: Lung adenocarcinoma (LUAD) is the most predominant histological subtype of lung cancer characterized by driver mutations detected in a substantial proportion of the cases. Tyrosine kinase inhibitors (TKIs) are standard care for the patients with these mutations. In this study, we evaluated the efficiency of an NGS-based 8-gene test in selecting TKIs-sensitive Chinese LUAD patients who are treatment-naïve.
Material and methods: Targeted sequencing covering the hotspot regions of eight LUAD driver genes was performed across 853 treatment-naïve LUAD patients. Logistic regression analysis was used to determine the factors associated with presence of these mutations. Genetically modified LUAD PC9 cells were established to evaluated the sensitivity of selected EGFRcompound mutations to different EGFR-TKIs in-vivo.
Results: A total of 574 single nucleotide variants, 270 InDels, 88 amplifications, and 87 rearrangements were identified in this study, with EGFR and KRAS being the most frequently mutated genes. Females, mostly life-long non-smokers, had significantly higher EGFRmutation rates than males and had a T>A conversion signature, for which the etiological factor is still unknown. Males, primarily smokers, more frequently had KRAS mutations and a smoking-associated signature of C>A conversions. Rare EGFR compound mutations identified in this study (Exon19del plus L747S/I744V and L858R plus V843I/T854A/G873) conferred genetically modified PC9 cells, constantly and consistently, more sensitive to second-generation EGFR-TKI afatinib in-vivo.
Conclusion: Over 70% of Chinese treatment-naïve LUAD patients are TKIs-targetable. Patients with rare EGFR compound mutations might conside second-generation EGFR-TKIs for treatment.