bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inclusion Of Perineural Invasion With AJCC-TNM Staging: Outcomes From A South East Asian Cohort Of Curatively Treated Gastric Cancer Patients
Authors: Muduly Dillip Kumar , Kar Madhabananda , Sultania Mahesh , Shahin Mohammed , Patra Susama , Singh Viswajeet , Imaduddin Mohammed , Nayak Hemant , Panigraphi Manas Kumar , Mohakud Sudipta 
Published: January 2022

Abstract
Background: The incidence of perineural invasion (PNI) in patients with gastric cancer (GC) is high, and patients with PNI positive disease have a poor prognosis compared to PNI negative disease. The present study aims to study the incidence and evaluate the impact of PNI on the survival outcome of a cohort of Eastern Asian GC patients. Material and Methods: All consecutive patients undergoing curative gastrectomy were included in the study. The incidence of PNI and correlation with different clinicopathological features and overall survival was performed.Results: 59.54% had PNI positive disease and the median OS of PNI+ve patients was 29.3 months, while it was not reached in PNI-ve patients. The PNI positivity was a significant prognostic factor for overall survival both on univariate and multivariate analysis. On TNM-PNI staging, those with TNM stage I / II patients with PNI+ve disease had similar OS to all stage III patients (p=0.835) and was worse than that of PNI-ve patients (p<0.05). Conclusion: The incidence of PNI in gastric cancer is high. The inclusion of PNI with AJCC-TNM staging may better stratify prognostic staging in curatively treated gastric cancer patients.
In-vitro and In-vivo Characterization of Entacapone Loaded Nanostructured Lipid Carriers Developed by Quality-By-Design Approach
Authors: Agrawal Yogeeta O , Patil Kiran D , Mahajan Hitendra S , Potdar Mrugendra B , Joshi Pratiksha , Nakhate Kartik 
Published: January 2022

Abstract
Entacapone, a reversible catechol-o-methyl transferase inhibitor, is used to enhance the action of dopamine agonists by reducing their metabolism and the "Wearing-off" effects associated with long-term use in the treatment of Parkinson's disease. It is used as an adjunct to levodopa/Carbidopa therapy. Due to limited dissolution and first-pass clearance, it suffers from low and variable bioavailability. The present study aims to explore the potential of nanostructured lipid carriers(NLCs) for the delivery of Entacapone. The Quality by Design (QbD) approach was used for the systematic development of NLCs. The 23 full factorial design were investigated using Design-Expert®11 software. The three independent variables viz. content of total lipid (X1), surfactant (X2), and sonication time (X3) were optimized against two responses viz. particle size and entrapment efficiency. The optimized NLCs were characterized for their size, surface morphology, entrapment efficiency, drug release, thermal and crystallographic studies. The prepared Entacapone-loaded NLCs were capable of sustaining the release of the drug within therapeutic concentration for a prolonged time. In-vivo pharmacokinetic studies in Entacapone-loaded NLCs showed an increase in t1/2, AUC0-∞, MRT compared to free drug, which confirms the enhancement of bioavailability while the reduction in elimination (Kel) depicts prolonged action of Entacapone by loading in NLCs. The results displayed Entacapone loaded NLCs have promising potential for oral delivery and may enhance the therapeutic effect and thereby reduce the dosing frequency which is a major issue with the present drug.
Effect of Staining Beverages and Bleaching on Optical Properties of CAD/CAM Nanohybrid and Nanoceramic Restorative Materials
Authors: Elsaka Shaymaa , Taibah Salwa , Elnaghy Amr 
Published: January 2022

Abstract
Background: The purpose of this study was to evaluate the optical properties of nanohybrid Grandio (GR) and nanoceramic Lava Ultimate (LU) CAD/CAM restorative materials subjected to different beverage solutions and subsequent bleached. Methods: Five groups of each restorative material (n = 20/group, A2 shaded-high translucency) were immersed in distilled water, coffee, tea, cola, and ginger for one week. Changes in whiteness index, translucency parameter, and color changes of the specimens were evaluated. The data of color measurements after staining, bleaching, and the residual difference were statistically analyzed using Kruskal-Wallis and Mann-Whitney U tests at the significance level of P < 0.05. Results: LU and GR revealed the highest differences in whiteness index after coffee staining (P < 0.001). GR revealed lower translucency parameter differences after staining with coffee than LU (P = 0.007). There were no significant differences in translucency changes between LU and GR after staining with tea, cola, or ginger (P > 0.05). LU revealed significantly greater color changes than GR after staining (P < 0.001). Conclusions: LU nanoceramic CAD/CAM restorative material revealed higher color changes than GR nanohybrid material. Staining beverage solutions had a distinct influence on the optical properties of tested CAD/CAM restorative materials.
Cost-effectiveness evaluation of powered staplers in video assisted thoracoscopic lung resection procedures
Authors: Han Yi , Zhang Yong , Zhu Hong 
Published: January 2022

Abstract

Background: Video-assisted thoracic surgery (VATS) is currently established as the preferred approach for surgical resection of early-stage lung cancer and has been recommended by multiple clinical associations. This study aimed at evaluating the cost-effectiveness of powered vs manual staplers in video-assisted thoracic surgery (VATS) for lung lobectomy in support of hospital-based health technology assessment.Methods: Clinical and economic comparisons between powered endoscopic staplers (PES) and manual endoscopic staplers (MES) in VATS lobectomies were conducted using a decision tree model from the perspective of hospital administrators. Prolonged air leak (PAL) was selected as the surgery complication for the model. Clinical performances measured by PAL rates for the staplers were obtained from a targeted literature review. The economic parameters used in the model were based on results from real-world data analysis in China. The outcomes used in the cost-effectiveness analysis were total costs and post-discharge 6-month reoperation rates. Cost-effectiveness was measured by the incremental cost per reduction of reoperation. Model stability was evaluated using both one-way sensitivity analysis and probabilistic sensitivity analysis (PSA). Results: Deterministic calculation results showed powered staplers dominated manual stapler, with lower per-episode costs (CNY 83,487 for PES vs CNY 86,239 for MES) and lower reoperation rates (0.54% for PES vs 0.63% for MES). One-way sensitivity analysis and PSA results further supported that the powered stapler was the dominant strategy for VATS lobectomies. Conclusions:The cost-effectiveness analysis demonstrated powered staplers are cost-effective compared to manual staplers in VATS lobectomies.
3D Many-objective DV-hop Localization Model With NSGA3
Authors: Wang Penghong , Li Hangjuan , Cai Xingjuan 
Published: January 2022

Abstract
Wireless sensor location is a challenging task issue in the Internet of Things (IoT). Distance vector-hop (DV-hop) algorithm provides a range-free positioning scheme, but its position prediction method based on least square method brings a large positioning error. To overcome this issue, this paper constructs a three-dimensional (3D) many-objective positioning model. Specifically, we consider many factors, such as the error characteristics of the estimated distance, the distribution characteristics of nodes and the computational cost. Based on these factors, we propose a many-objective 3D-DV-hop positioning model, and propose a data preprocessing strategy and outlier removal strategy. Finally, a fashionable many-objective optimization algorithm is employed to solve the model. The experimental results show that the model proposed in this paper has great advantages in accuracy and robustness, and is superior to the current single and multi-objective positioning model.
Aggregation of magnetic nanoparticles functionalized with trans-resveratrol in aqueous solution
Authors: Nguyen Thi-Nga , Tran Quang-Hung , Charnay Clarence , Dumail Xavier , Reibel Corinne , Cazals Guillaume , Valette Gilles , Jay-Allemand Christian , Terki Ferial , Bidel Luc P. R. 
Published: January 2022

Abstract
In the framework of a protein-ligand-fishing strategy to identify proteins that bind to trans-resveratrol, a natural phenolic compound with pharmacological benefits, we have developed magnetic nanoparticles covalently linked to trans-resveratrol through three different derivatives and examined their aggregation behavior in aqueous solution. The monodispersed magnetic core (18 nm) with its mesoporous silica shell (93 nm) exhibited a notable superparamagnetic behavior useful for magnetic bioseparation. The hydrodynamic diameter, deduced from dynamic light scattering analysis, of the nanoparticle increased from 100 to 800 nm when the aqueous buffer changed from pH 10.0 to 3.0. A size polydispersion occurred from pH 7.0 to 3.0. In parallel, the value of the extinction cross-section increased according to a negative power law of the UV wavelength. This was mainly due to light scattering by mesoporous silica, whereas the absorbance cross-section remained very low in the 230-400 nm domain. The three types of resveratrol-grafted magnetic nanoparticles exhibited similar scattering properties, but their absorbance spectrum was consistent with the presence of trans-resveratrol. Their functionalization increased their negative zeta potential when pH increased from 3.0 to 10.0. The mesoporous nanoparticles were monodispersed in alkaline conditions, where their anionic surface strongly repulsed each other but aggregated progressively under van der Waals forces and hydrogen bonding when negative zeta potential decreased. The characterized results of nanoparticle behavior in aqueous solution provide critical insigh for further study of nanoparticles with proteins in biological environment.
Antibody response to SARS-CoV-2 mRNA vaccines in patients with rheumatic diseases in Japan: Interim analysis of a multicenter cohort study
Authors: Kashiwado Yusuke , Kimoto Yasutaka , Sawabe Takuya , Irino Kensuke , Nakano Shota , Hiura Junki , Wang Qiaolei , Kawano Shotaro , Ayano Masahiro , Mitoma Hiroki , Ono Nobuyuki , Arinobu Yojiro , Niiro Hiroaki , Hotta Taeko , Kang Dongchon , Akashi Koichi , Ohshima Shiro , Takeuchi Tsutomu , Horiuchi Takahiko 
Published: January 2022

Abstract
Background: To evaluate the impact of medication on antibody response to SARS-CoV-2 mRNA vaccines in Japanese patients with rheumatic diseases.Methods: This prospective multicenter cohort study evaluated the humoral response in 12 different medication groups. Antibody levels before the first vaccination and 3-6 weeks after the second vaccination were measured using the Elecsys Anti-SARS-CoV-2 S assay. Statistical analysis included comparing antibody titers among the different medication groups using the Kruskal–Wallis test followed by the Bonferroni–Dunn test for multiple comparisons and multiple linear regression analysis.Results: Three hundred and seventy-two patients receiving treatment for rheumatic diseases were enrolled, and 295 patients were analyzed. The seroconversion rate was 92.2% and the median antibody titer was 255 U/ml (interquartile range; IQR, 34.1-685) after the second mRNA vaccination. Antibody levels were significantly lower in the groups treated with TNF inhibitor (TNFi) with methotrexate (MTX) (median, 104 U/ml; IQR, 33.2-260), abatacept (median, 48.2 U/ml; IQR, 17.9-182), mycophenolate mofetil (MMF) (median, 3.24 U/ml; IQR, 0-34), MMF or mizoribine (MMF/MZR) combined with calcineurin inhibitor (CNI) (median, 5.5 U/ml; IQR, 0-21), and rituximab or cyclophosphamide (RTX/CPA) (median, 19.5 U/ml; IQR, 0-142) compared with those treated with sulfasalazine and/or bucillamine (median, 831 U/ml; IQR, 451-1451.5) or CNI (median, 833 U/ml; IQR, 164-1882) (p<0.01). Conclusions: Additional early vaccination is required in patients treated with TNFi and MTX, ABT, MMF, MMF or MZR combined with CNI and CPA/RTX. However, patients treated with CNI and sulfasalazine and/or bucillamine may be safer among patients with rheumatic diseases.
A simple method of searching for a fixed solution in a coordinate domain
Authors: Cellmer Sławomir 
Published: January 2022

Abstract
Recently, more and more Global Navigation Satellite Systems satellites are available for observation. Apart from obvious advantages, this brings new challenges in developing efficient computational methods of processing signals obtained from more satellites than to date. From the viewpoint of computation process efficiency, the most critical step is ambiguity resolution. Because of the discrete character of ambiguities, the search procedure is employed to perform this task. The search space dimension significantly impacts a search procedure computational load. The time needed for obtaining a solution raises considerably when the search space dimension is greater. Therefore, the improved version of the well-known concept of searching for a fixed solution in a three-dimensional coordinate domain was proposed and tested. The math model of the proposed approach is presented together with the algorithm of the search procedure. The numerical experiments were designed for simulated and real data. The simulated data has been prepared based on the concept proposed by the authors. This data simulation method is described in detail. The test results confirmed the reduction of the time needed to obtain the results when the proposed method is applied. This advantage over traditional methods unveils in the case of many satellites. Moreover, the real-data test pointed out that using the new approach is beneficial in reducing the computation time also in the case of a few satellites if long sessions are processed.
Development and performance of a HemeLB GPU code for human-scale blood flow simulation
Authors: Zacharoudiou I. , McCullough J.W.S. , Coveney P.V. 
Published: January 2022

Abstract

In recent years, it has become increasingly common for high performance computers (HPC) to possess some level of heterogeneous architecture - typically in the form of GPU accelerators. In some machines these are isolated within a dedicated partition, whilst in others they are integral to all compute nodes - often with multiple GPUs per node - and provide the majority of a machine's compute performance. In light of this trend, it is becoming essential that codes deployed on HPC are updated to execute on accelerator hardware. In this paper we introduce a GPU implementation of the 3D blood flow simulation code HemeLB that has been developed using CUDA C++. We demonstrate how taking advantage of NVIDIA GPU hardware can achieve significant performance improvements compared to the equivalent CPU only code on which it has been built whilst retaining the excellent strong scaling characteristics that have been repeatedly demonstrated by the CPU version. With HPC positioned on the brink of the exascale era, we use HemeLB as a motivation to provide a discussion on some of the challenges that many users will face when deploying their own applications on upcoming exascale machines.
M6A-Mediated Upregulation of CircMDK Promotes Tumorigenesis and Acts as a Nanotherapeutic Target in Hepatocellular Carcinoma
Authors: Du Ashuai , Li Shiqin , Zhou Yuzheng , Disoma Cyrollah , Liao Yujie , Zhang Yongxing , Chen Zongpeng , Yang Qinglong , Liu Pinjia , Liu Sixu , Dong Zijun , Razzaq Aroona , Tao Siyi , Chen Xuan , Liu Yuxin , Xu Lunan , Zhang Qianjun , Li Shanni , Peng Jian , Xia Zanxian 
Published: January 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
Heuristic Methods for Minimizing Cut Bars and Using Leftovers from the One-dimensional Cutting Process
Authors: Bressan Glaucia Maria , Pimenta-Zanon Matheus , Sakuray Fabio 
Published: January 2022

Abstract
The cutting problems consist in cutting a set of objects available in stock in order to produce the desired items in specified quantities and sizes. The one-dimensional cutting stock problem involves only one of the relevant dimensions in the cutting process, as in cutting bars, rolls and tubes. The cutting process can generate leftover (which can be reused in a new demand) or losses (which are discarded). This paper presents two heuristic methods for minimizing the number of cut bars in the one-dimensional cutting process, satisfying the items demand in an unlimited bars quantity of just one type. The results of simulations are compared with methods from literature and with the limiting values for this considered type of problem. The results show that proposed heuristics reduce processing time and the number of bars needed in cutting process, while it provides a greater leftover (by grouping losses) for the one-dimensional cutting stock problem. The heuristics contribute to reduction of raw materials or manufacturing costs in industrial processes, such as the automotive industry, construction, bicycle manufacturing and other purposes.
The antimicrobial quantitative relationship and mechanism of plant flavonoids to gram-positive bacteria
Authors: Yuan Ganjun , Xia Xuexue , Guan Yingying , Yi Houqin , Lai Shan , Sun Yifei , Cao Seng 
Published: January 2022

Abstract
Antimicrobial resistance (AMR) poses a serious threat to human health, and new antimicrobial agents are desperate in need. Plant flavonoids have been increasingly paid attention to, for their antibacterial activities, combinational effects on enhancing the antibacterial activity, and reversing the AMR. Based on our previous work, another two regression equations were established once again between the minimum inhibitory concentrations (MICs) (y) and the lipophilicity parameters ACD/LogP or LogD (x). After comparing the fitting goodness of four equations including two published by us, the best one, regarded as the antimicrobial quantitative relationship of plant flavonoids to gram-positive bacteria, was y = -0.1285x6 + 0.7944x5 + 51.785x4 - 947.64x3 + 6638.7x2 - 21273x + 26087, and here x is the LogP value. From this equation, the MICs of most plant flavonoids to gram-positive bacteria can be calculated. The minimum MIC was also predicted as approximately 0.9644 μM, and likely from 0.24 to 0.96 μM. Further, this more reliable equation further proved that the lipophilicity is a key factor of plant flavonoids against gram-positive bacteria. Combined with the antibacterial mechanism suggested in our previous work and the support from recent literature, more intuitive evidence powerfully confirmed the antibacterial mechanism that the cell membrane is the major site of plant flavonoids acting on gram-positive bacteria, and that involving the damage of phospholipid bilayers.
ANALISIS HARGA SAHAM SEKTOR ANEKA INDUSTRI YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Nadhifah Nadhifah , Ediwarman Ediwarman , Pangestu Dewi Cahyani 
Published: January 2022

ABSTRAK Penelitian ini bertujuan untuk menilai pengaruh Profitabilitas, Likuiditas dan Leverage terhadap Harga Saham. Populasinya seluruh perusahaan sektor aneka industri yang terdaftar di Bursa Efek Indonesia. Dengan menggunakan metode purposive sampling didapat 22 perusahaan sektor aneka industri dengan periode empat tahun penelitian sehingga memperoleh 88 data. Teknik analisis data yang digunakan adalah Analisis Regresi Data Panel dengan bantuan Eviews 11 menggunakan signifikansi 5%. Penelitian ini menunjukkan hasil bahwa Profitabilitas yang diukur dengan Return on Equity (ROE) berpengaruh positif terhadap Harga Saham, Likuiditas yang diukur dengan Current Ratio (CR) tidak berpengaruh terhadap Harga saham dan Leverage yang diukur dengan Debt to Equity Ratio (DER) berpengaruh positif terhadap Harga Saham. Kata Kunci : harga saham; profitabilitas; likuiditas; leverage ABSTRACT This study aimed to assess the effect of Probability, Liquidity and Leverage on Stock Price. The population is all Miscellaneous Industry Sector Companies Listed in Indonesia Stock Exchange. By using Purposive Sampling method, obtained 22 companies in the Miscellaneous Industry Sector with a research period of four years to obtain 88 data. Data analysis technique by using Panel Data Regression Analysis with Eviews 11 and significant 5%. This study shows the results that profitability as measured by Return on Equity (ROE) has a positive effect on Stock Price, Liquidity as measured by Current Ratio (CR) has no effect on Stock Price and Leverage as measured by Debt to Equity Ratio (DER) has a positive effect on Stock Price. Keywords : stock price; profitability; liquidity; leverage
Enzyme complexes for activating yeast generation and ethanol fermentation
Authors: Rimareva Liubov , Serba Elena , Overchenko Marina , Shelekhova Nataliya , Ignatova Nadezhda , Pavlova Anzhelika 
Published: January 2022

Introduction. Recent studies have shown the benefits of phytolytic enzymes to prepare grain wort in ethanol production. However, there is a lack of data on the effect of phytases and their amount on the conversion of grain polymers, the ionic composition of wort and mash, and the efficiency of yeast generation and ethanol fermentation.
Study objects and methods. Wheat and corn wort samples were treated with a complex of hydrolases, including phytases. Capillary electrophoresis determined the ionic composition of wort and mash. Gas chromatography measured the content of volatile metabolites.
Results and discussion. The key enzymes were phytases and proteases. They improved the conversion of grain polymers and stimulated the growth and metabolism of yeast cells. Their synergism enriched the wort with assimilable nitrogen, phosphorus, and other valuable minerals. In addition, it intensified the growth of the Saccharomyces cerevisiae yeast, increased the rate of carbohydrate consumption, and reduced the formation of side metabolites 1.7–1.9 times, mainly due to higher and aromatic alcohols. The concentration of phosphates remained practically unchanged during the fermentation of grain wort treated with phytases. However, by the end of fermentation, it was 2.4–5.1 times higher than in the mash samples without phytolytic treatment. Finally, we identified a complex of enzymes and optimal amounts of phytases that have a stimulating effect on ethanol fermentation.
Conclusion. Phytases, whether used individually or together with proteases, enriched grain wort with soluble macro- and microelements, improved yeast metabolism, directed ethanol synthesis, and decreased the formation of fermentation by-products.