bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personality traits and quality of life among Lebanese medical students: any mediating effect of emotional intelligence? A path analysis approach
Authors: Maalouf Elise , Hallit Souheil , Obeid Sahar 
Published: February 2022

Abstract
Background
Medicine is an incredibly demanding career that appears to leave many medical students at risk of fatigue, anxiety, depression and burnout. Since adaptation and lifestyle changes are important, quality of life (QOL) of students during medical school could be impaired. Personality traits and emotional intelligence (EI) facets may be both linked to medical student’s QOL. To our knowledge, no studies have been done on the concurrent and prospective relationship between QOL-related personality traits and EI in Lebanese medical students. This study aimed to investigate the role of EI as a mediator between personality traits and QOL among a sample of Lebanese medical students.

Methods
This research is a descriptive cross-sectional survey study involving 293 Lebanese medical students recruited from all 7 Faculties of Medicine in Lebanon (June–December 2019). Structural equation modeling (SEM) was performed using SPSS AMOS v.24 to examine the structural relationship between each personality trait taken as independent variables, QOL as the dependent variable, and emotional intelligence as the mediator, among university students. The relative Chi-square (χ2/df), root mean square error of approximation (RMSEA) statistic, Tucker Lewis Index (TFI) and the comparative fit index (CFI) were used to evaluate the goodness-of-fit of the model.

Results
Higher conscientiousness was significantly associated with more EI (Beta = 0.38; p < 0.001) and lower QOL (Beta = − 0.14; p = 0.025). The indirect relationships between conscientiousness, EI and QOL showed that EI mediated the association between conscientiousness and QOL (Beta = 0.17; 95% CI − 0.73 to − 0.004; p = 0.037). The fit indices of this model were adequate for χ2/df, RMSEA and CFI but not TLI. Higher openness to experience was significantly associated with more EI (Beta = 0.48; p < 0.001) and lower QOL (Beta = − 0.38; p < 0.001). The indirect relationships between openness to experience, EI and QOL showed that EI mediated the association between openness to experience and QOL (Beta = 0.30; 95% CI − 1.11 to − 0.03; p = 0.04). The fit indices were adequate for χ2/df and CFI but not RMSEA and TLI. EI did not mediate the association between the other three personality traits (extroversion, agreeableness and neuroticism) and QOL.

Conclusion
This current research has shed considerable light on the nexus of associations between EI, personality traits and well-being, nonetheless, led to the creation of more puzzling questions. On the whole, it seems that EI and its components can be used as an evaluation instrument in relates with Lebanese medical students’ personality profile as a means of future training to improve quality of life during medical education.
Self and suffering in Indian thought: implications for clinicians
Authors: Singh Swaran P. 
Published: February 2022

SUMMARYThe four main Indian religions – Hinduism, Buddhism, Jainism and Sikhism – have several shared concepts about self and suffering, which are salient to the world-view of the followers of these faiths. Understanding the concepts of mind, self and suffering in these faiths can help clinicians build better rapport and gain deeper understanding of the inner world of patients of these faiths. This article highlights the broad cultural and religious beliefs of these groups, with the hope that increased knowledge among clinicians might lead to better therapeutic engagement.
Endoscopic Transcortical-Transventricular Approach in Treating Third Ventricular Craniopharyngiomas—Case Series With Technical Note and Literature Review
Authors: Shoubash Loay I. , El Refaee Ehab , Al Menabbawy Ahmed , Refaat Mohamed I. , Fathalla Hussein , Schroeder Henry W. S. 
Published: February 2022

BACKGROUND:
A paradigm shift toward less radicality in the treatment of craniopharyngioma (CP) has increasingly gained recognition. In selected patients, a less invasive approach aiming at cyst decompression may be suitable.

OBJECTIVE:
To present our experience with the endoscopic transcortical-transventricular approach (ETTA) for the treatment of CP located in the third ventricle, describe our surgical technique, and explore the results reported in the literature.

METHODS:
Data for third ventricular CPs treated using ETTA in 2 tertiary medical centers between 2006 and 2020 were retrospectively reviewed. Cystic, mixed lesion, new, and recurrent cases were included. ETTA aimed at cyst fenestration, subtotal or partial tumor resection, managing the hydrocephalus, or a combination of these modalities. Fractionated radiotherapy (RT) was performed (54 Gy in 30 fractions).

RESULTS:
The described approach was performed in 13 patients with a mean age of 30.2 years. Tumor excision was attempted in 10 patients. Cystic fenestration alone was conducted in 3 patients, followed by intracystic catheter implantation in 2 patients. Permanent diabetes insipidus developed in 3 patients, and 1 patient experienced a surgical site infection. The recurrence rate for ETTA + RT (pre-ETTA in 33.3%) was 2/9 (22.2%) after a mean follow-up of 21.3 months. Four patients did not undergo RT after ETTA, and all these patients experienced recurrences after a mean follow-up of 15.5 months. Hydrocephalus resolved in all 6 patients who presented with accompanying hydrocephalus.

CONCLUSION:
ETTA combined with adjuvant RT is a safe and effective option in the management of cystic or predominantly cystic CP extending into the third ventricle. This procedure also effectively treats the accompanying hydrocephalus.
Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor Under General Anesthesia: Technical Note
Authors: Mensah-Brown Kobina G. , Yang Andrew I. , Hitti Frederick L. , Henry Lenora , Heman-Ackah Sabrina M. , Chaibainou Hanane , Baltuch Gordon H. 
Published: February 2022

BACKGROUND:
Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is an incisionless therapy for the treatment of medication-resistant essential tremor. Although its safety and efficacy has been demonstrated, MRgFUS is typically performed with the patient awake, with intraprocedural neurological assessments to guide lesioning.

OBJECTIVE:
To report the first case of MRgFUS thalamotomy under general anesthesia in a patient whose medical comorbidities prohibit him from being in a supine position without a secured airway.

METHODS:
The dentatorubrothalamic tract was directly targeted. Two sonications reaching lesional temperatures (≥54°C) were delivered without any complications.

RESULTS:
Lesioning was confirmed on intraoperative magnetic resonance imaging, and the patient experienced 89% improvement in his tremor postoperatively.

CONCLUSION:
This demonstrates the safety and feasibility of MRgFUS thalamotomy under general anesthesia without the benefit of intraprocedural neurological assessments.
Tcf12 and NeuroD1 cooperatively drive neuronal migration during cortical development
Authors: Singh Aditi , Mahesh Arun , Noack Florian , Cardoso de Toledo Beatriz , Calegari Federico , Tiwari Vijay K. 
Published: February 2022

ABSTRACT
Corticogenesis consists of a series of synchronised events, including fate transition of cortical progenitors, neuronal migration, specification and connectivity. NeuroD1, a basic helix-loop-helix (bHLH) transcription factor (TF), contributes to all of these events, but how it coordinates these independently is still unknown. Here, we demonstrate that NeuroD1 expression is accompanied by a gain of active chromatin at a large number of genomic loci. Interestingly, transcriptional activation of these loci relied on a high local density of adjacent bHLH TFs motifs, including, predominantly, Tcf12. We found that activity and expression levels of Tcf12 were high in cells with induced levels of NeuroD1 that spanned the transition of cortical progenitors from proliferative to neurogenic divisions. Moreover, Tcf12 forms a complex with NeuroD1 and co-occupies a subset of NeuroD1 target loci. This Tcf12-NeuroD1 cooperativity is essential for gaining active chromatin and targeted expression of genes involved in cell migration. By functional manipulation in vivo, we further show that Tcf12 is essential during cortical development for the correct migration of newborn neurons and, hence, for proper cortical lamination.
LMBR1L regulates the proliferation and migration of endothelial cells through Norrin/β-catenin signaling
Authors: Liu Wenjing , Jiang Xiaoyan , Li Xiao , Sun Kuanxiang , Yang Yeming , Yang Mu , Li Shujin , Zhu Xianjun 
Published: February 2022

ABSTRACT
Precise Norrin and β-catenin (Norrin/β-catenin; encoded by NDP and CTNNB1, respectively) signaling is critical for proper angiogenesis. Dysregulation of this signaling leads to various diseases, of which retinal exudative vitreoretinopathy is the most prevalent. Here, we used a global knockout mouse model to show that limb development membrane protein 1 like (LMBR1L), a transmembrane protein of unknown function in angiogenesis, is essential for retinal vascular development. In vitro experiments revealed that LMBR1L depletion results in aberrant activation of the Norrin/β-catenin signaling pathway via decreased ubiquitylation of FZD4 and increased Norrin co-receptor LRP5 and p-GSK3β-Ser9 expression levels, which cause accumulation of β-catenin. Moreover, inhibition of LMBR1L in human retinal microvascular endothelial cells (HRECs) caused increased proliferation ability and defective cell migration, which might have occurred as a result of upregulated expression levels of the apical junction components. Treatment with p-GSK3β-Ser9 inhibitor AR-A014418 restored the phenotypes in LMBR1L-null HRECs, which further demonstrated the important regulatory role of LMBR1L in the Norrin/β-catenin signaling pathway. Taken together, our data reveal an essential role for LMBR1L in angiogenesis.
This article has an associated First Person interview with the first author of the paper.
Current state of knowledge and concerns regarding cardiopulmonary resuscitation performed in the setting of out-of-hospital sudden cardiac arrest among adult, non-medical rural residents
Authors: Budzyńska Julia , Kozioł Ilona , Leśniewska Magdalena , Szaniawska Monika , Szast Konrad 
Published: February 2022

INTRODUCTION Every year in Poland 56,000 outside the hospital there is a sudden cardiac arrest.
OBJECTIVES The aim of the study was to determine the level of knowledge of basic life support undertaken in prehospital management in rural areas. The second objective of the study was to assess needs for cardiopulmonary resuscitation(CPR) training among adults in rural areas.
MATERIAL AND METHODS The study was carried out with the use of an original questionnaire based on the review of literature and guidelines of the European Resuscitation Council. The questionnaire was shared by social media. The questionnaire consisted of the following parts: metric, experience of previous CPR, knowledge about CPR, assessment of demand and interest in expanding knowledge and skills in CPR. A total of 501 responses were collected, of which 316 from adult, non-medical rural residents were analyzed.
RESULTS Over 85% of respondents knew how to assess consciousness of the victim, 95% of respondents knew when to start CPR. About 33% of the respondents did not know the correct location of chest compressions. Moreover 65% of them could not identify the correct frequency of compressions. Although rib fracture was one of the most commonly cited concerns, it was a potential reason to discontinue CPR only for 4.5% of respondents.
CONCLUSIONS It was observed that there is a need for additional CPR training among rural adult residents. The information collected in this study may allow for the planning of appropriate educational activities to increase the level of knowledge about CPR in heart accidents.
Integrated Stochastic Optimal Self-Scheduling for Two-Settlement Electricity Markets
Authors: Pan Kai , Guan Yongpei 
Published: February 2022

The complexity of current electricity wholesale markets and the increased volatility of electricity prices because of the intermittent nature of renewable generation make independent power producers (IPPs) face significant challenges to submit offers. This challenge increases for those owning traditional coal-fired thermal generators and renewable generation. In this paper, an integrated stochastic optimal strategy is proposed for an IPP using the self-scheduling approach through its participation in both day-ahead and real-time markets (i.e., two-settlement electricity markets) as a price taker. In the proposed approach, the IPP submits an offer for all periods to the day-ahead market for which a multistage stochastic programming setting is explored for providing real-time market offers for each period as a recourse. This strategy has the advantage of achieving overall maximum profits for both markets in the given operational time horizon. Such a strategy is theoretically proved to be more profitable than alternative self-scheduling strategies as it takes advantage of the continuously realized scenario information of the renewable energy output and real-time prices over time. To improve computational efficiency, we explore polyhedral structures to derive strong valid inequalities, including convex hull descriptions for certain special cases, thus strengthening the formulation of our proposed model. Polynomial-time separation algorithms are then established for the derived exponential-sized inequalities to speed up the branch-and-cut process. Finally, both numerical and real case studies demonstrate the potential of the proposed strategy. Summary of Contribution: This paper develops innovative models and methods to study a family of practically important problems via the interactions of operations research and computing. Specifically, this paper provides in-depth analyses of innovative stochastic optimization modeling approaches and develops computationally efficient polyhedral results. The paper also verifies the effectiveness of proposed analyses via extensive computing experiments.
Pricing for Heterogeneous Products: Analytics for Ticket Reselling
Authors: Alley Michael , Biggs Max , Hariss Rim , Herrmann Charles , Li Michael Lingzhi , Perakis Georgia 
Published: February 2022

Problem definition: We present a data-driven study of the secondary ticket market. In particular, we are primarily concerned with accurately estimating price sensitivity for listed tickets. In this setting, there are many issues including endogeneity, heterogeneity in price sensitivity for different tickets, binary outcomes, and nonlinear interactions between ticket features. Our secondary goal is to highlight how this estimation can be integrated into a prescriptive trading strategy for buying and selling tickets in an active marketplace. Academic/practical relevance: We present a novel method for demand estimation with heterogeneous treatment effect in the presence of confounding. In practice, we embed this method within an optimization framework for ticket reselling, providing the ticket reselling platform with a new framework for pricing tickets on its platform. Methodology: We introduce a general double/orthogonalized machine learning method for classification problems. This method allows us to isolate the causal effects of price on the outcome by removing the conditional effects of the ticket and market features. Furthermore, we introduce a novel loss function that can be easily incorporated into powerful, off-the-shelf machine learning algorithms, including gradient boosted trees. We show how, in the presence of hidden confounding variables, instrumental variables can be incorporated. Results: Using a wide range of synthetic data sets, we show this approach beats state-of-the-art machine learning and causal inference approaches for estimating treatment effects in the classification setting. Furthermore, using National Basketball Association ticket listings from the 2014–2015 season, we show that probit models with instrumental variables, previously used for price estimation of tickets in the resale market, are significantly less accurate and potentially misspecified relative to our proposed approach. Through pricing simulations, we show our proposed method can achieve an 11% return on investment by buying and selling tickets, whereas existing techniques are not profitable. Managerial implications: The knowledge of how to price tickets on its platform offers a range of potential opportunities for our collaborator, both in terms of understanding sellers on their platform and in developing new products to offer them. History: This paper has been accepted as part of the 2019 Manufacturing & Service Operations Management Practice-Based Research Competition. Funding: This work was supported by the National Science Foundation [Grant CMMI-1563343]. Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2021.1065 .
Point-of-care blood testing with secondary care decision support for frail patients
Authors: Novak Alex , Cherry Joanna , Ali Nurul , Smith Ian , Bowen Jordan , Ray James , Black John JM , Cornett Ross , Taylor Sally , Hayward Gail , Lasserson Daniel 
Published: February 2022

Aim: A service evaluation was conducted to assess the feasibility and impact of a pilot service to facilitate alternatives to hospital admission for frail patients in supportive care settings. Paramedic assessments were enhanced by point-of-care testing and telephone support from senior physicians. Method: A rapid response vehicle, staffed by a specialist paramedic and equipped with the Abbott i-STAT Wireless 1 point-of-care testing platform that could transmit results to hospital electronic patient record (EPR) systems, was dispatched to frail, non-injured patients over a 3-month period. Results were obtained on scene and transmitted to Oxford University Hospitals EPR system. The patient was then discussed over the telephone with a senior acute medical assessment physician at the Trust for advice and decision support and to coordinate referral to secondary care or other services. Results: The analysis included 56 patients, 21 men and 35 women, with a median age of 86 years. Seventeen patients who had significantly deranged blood test results were transferred to hospital, as were another 10 who did not have such results; 27 patients were admitted in total. Twenty-nine patients remained in their usual environment; of these, four presented to hospital within the next 30 days, and no deaths or adverse events were reported. Conclusion: Point-of-care testing by the ambulance services is feasible and, when combined with telephone advice and decision support from secondary care physicians, may be effective in reducing hospital admission for frail patients in supportive care environments. Larger systematic evaluations are warranted to establish the utility and cost-effectiveness of point-of-care testing by ambulance services.
Attitudes towards influenza, and COVID-19 vaccines during the COVID-19 pandemic among a representative sample of the Jewish Israeli population
Authors: Maor Yasmin , Caspi Shaked 
Published: February 2022

Background
Vaccine hesitancy is increasing. We assessed attitudes toward influenza and COVID-19 vaccines and the relation between hesitancy to influenza vaccine and hesitancy towards COVID-19 vaccines.

Methods
A structured questionnaire administered during September 2020 to a representative sample of the Jewish Israeli population assessed attitudes and acceptance of influenza and COVID-19 vaccines. Factors for vaccine hesitancy were determined using logistic regression. Questionnaires were administered prior to the release of clinical data regarding efficacy and safety of COVID-19 vaccines and prior to vaccine rollout.

Results
We approached 10,625 people, of these 2,080 responded (19%), and 2,024 completed the questionnaire (97.3%), 64.9% aged 15–64 years and 35.1% aged ≥65 years. 37% had co-morbidities. 43.5% experienced financial deterioration due to the pandemic. 65.9% received influenza vaccine ≥1 time in the past. Influenza vaccination rates were higher in the elderly (81.8%). Reasons for influenza vaccine hesitancy were opinions that the vaccine is ineffective (27.1%), and fear of side effects (29.3%). 8.2% of people aged 16–64 and 13.8% of people aged≥65 refused to be vaccinated at least once over the course of one’s lifetime. Percent of responders willing to receive a COVID-19 vaccine were higher than percent of responders willing to receive the influenza vaccine both in people aged 16–64 years (942 (72.3%) vs. 38.4%, respectively) and in people 65 years and older (84.0% vs. 76.8%, respectively). Hesitancy towards COVID-19 vaccine was associated with hesitancy towards other vaccines. Only 26.8% would participate in a COVID-19 vaccine trial.

Conclusions
Willingness to receive COVID-19 vaccine was higher than willingness to receive influenza vaccine. The results point to areas of fear from influenza vaccines side effects and lack of knowledge regarding influenza vaccines effectiveness that can be addressed to increase acceptance. Hesitancy towards other vaccines was associated with hesitancy towards COVID-19 vaccination.
A systematic review of disease related stigmatization in patients living with prostate cancer
Authors: Larkin Derek , Birtle Alison J. , Bradley Laura , Dey Paola , Martin Colin R. , Pilkington Melissa , Romero-Rivas Carlos 
Published: February 2022

Background
Prostate cancer has been shown to be susceptible to significant stigmatisation, because to a large extent it is concealable, it has potentially embarrassing sexual symptoms and has significant impact on the psychosocial functioning.

Methods
This review included studies that focused on qualitative and/or quantitative data, where the study outcome was prostate cancer and included a measure of stigmatization. Electronic databases (CINAHL, Medline, PubMed, PsycInfo, Cochrane Library, PROSPERO, and the Joanna Briggs Institute) and one database for grey literature Opengrey.eu, were screened. We used thematic analysis, with narrative synthesis to analyse these data. We assessed risk of bias in the included studies using the RoBANS.

Results
In total, 18 studies met review inclusion criteria, incorporating a total of 2295 participants. All studies recruited participants with prostate cancer, however four studies recruited participants with other cancers such as breast cancer and lung cancer. Of the 18 studies, 11 studies evaluated perceived or felt stigma; four studies evaluated internalised or self-stigma; three studies evaluated more than one stigma domain.

Discussion
We found that patients living with prostate cancer encounter stigmatisation that relate to perception, internalisation, and discrimination experiences. We also identified several significant gaps related to the understanding of prostate cancer stigmatization, which provides an opportunity for future research to address these important public health issues.

Registration
This systematic review protocol is registered with PROSPERO, the international prospective register of systematic reviews in health and social care. Registration number: CRD42020177312.