bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potential of Natural Products in the Treatment of Triple-negative Breast Cancer
Authors: Ke Danny Yu Jia , El-Sahli Sara , Wang Lisheng 
Published: December 2021

Abstract:
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks receptors
for targeted therapy. Consequently, chemotherapy is currently the mainstay of systemic treatment
options. However, the enrichment of cancer stem cells (CSC, a subpopulation with stem-cell characteristics
and tumor-initiating propensity) promotes chemo-resistance and tumorigenesis, resulting
in cancer recurrence and relapse. Furthermore, toxic side effects of chemotherapeutics reduce patient
wellbeing. Natural products specifically compounds derived from plants, have the potential to
treat TNBC and target CSCs by inhibiting CSC signaling pathways. Literature evidence from six
promising compounds was reviewed, including sulforaphane, curcumin, genistein, resveratrol, lycopene,
and epigallocatechin-3-gallate. These compounds have been shown to promote cell cycle
arrest and apoptosis in TNBC cells. They also could inhibit the epithelial-mesenchymal transition
(EMT) that plays an important role in metastasis. In addition, those natural compounds have been
found to inhibit pathways important for CSCs, such as NF-κB, PI3K/Akt/mTOR, Notch 1, Wnt/β-
catenin, and YAP. Clinical trials conducted on these compounds have shown varying degrees of effectiveness.
Epidemiological case-control studies for the compounds commonly consumed in certain
human populations have also been summarized. While in vivo and in vitro data are promising,
further basic and clinical investigations are required. Likely, natural products in combination with
other drugs may hold great potential to improve TNBC treatment efficacy and patient outcomes.
Asymmetric Synthesis of 2,3-Dihydrofurans via Squaramide Catalyzed
Michael-Alkylation Reaction
Authors: Ma Zhi-Wei , Wang Chuan-Chuan , Chen Xiao-Pei , Sun Bin , Tao Jing-Chao , Lv Quan-Jian 
Published: December 2021

Abstract:
A highly stereoselective methodology was developed to construct dihydrofurans. In the
presence of a bifunctional squaramide catalyst, the Michael addition/cyclization between cyclohexane-
1,3-dione and α-bromonitroalkenes occurred smoothly to provide the desired dihydrofurans with high
to excellent yields (90-94%) and good to high enantioselectivities (80-94% ee). This catalytic protocol
was compatible with a range of structurally distinct α-bromonitroalkenes.
Chiral Allenylcarbonyls – Underexploited Building Blocks for Complex
Synthesis
Authors: Yadavalli Krishna , Lepore Salvatore D. 
Published: December 2021

Abstract:
Chiral allenylcarbonyls such as allenoates remain underutilized in complex synthesis
despite recent advances in synthesis methods to prepare them non-racemically. The field is now
ripe for the employment of this class of allenes as building blocks to facilitate the construction of
complex small-molecule compounds, such as bridged bicycles.
Benign Synthesis of Metal-organic Framework (MIL-101-Cr) and Evaluation of Carbon-
dioxide Adsorption Behaviour Employing Adsorption Isotherm Models
Authors: Kayal Sibnath , Singh Ayushi 
Published: December 2021

Background:
In today’s world, rising temperature due to global warming is caused by higher concentration of carbon dioxide (CO2) emissions in the atmosphere. Metal-Organic Framework (MOF) materials have
the potential to be used in carbon dioxide capture and utilization technology.

Objective:
The purpose of this work is to prepare metal-organic framework materials by a benign synthesis method using water as the solvent, followed by the characterization and property evaluation for CO2 adsorption study.

Methods:
MIL-101-Cr metal-organic framework and its derivatives with alkali ion dopants were prepared by benign hydrothermal synthesis route, which were characterized by powder X-ray diffraction method. The adsorption
isotherms of CO2 for MIL-101-Cr and its derivatives were studied to comprehend the influence of alkali dopants
on CO2 sorption behaviour. The equilibrium uptakes of CO2 were further evaluated by fitting the isotherms with
Langmuir, Toth and Dubinin – Astakohv adsorption models to determine the adsorption parameters. Results: The
crystalline structural integrity of MIL-101-Cr is not affected by doping with alkali ions. The isosteric heat of CO2
adsorption is diminished with an increase in alkali dopant size, while the induced surface structural heterogeneity
increases with increasing alkali dopant size.

Conclusion:
The equilibrium and thermodynamic parameters calculated from this study are useful
for applications in carbon dioxide capture and utilization technology.
N-heterocycles: Recent Advances in Biological Applications
Authors: Dinodia Monica 
Published: December 2021

Abstract:
Nitrogen based heterocycles display an impressive repertoire of biological activities, including antioxidant, antimicrobial, anti-tuberculosis, analgesic, anti-inflammatory, anti-viral, anti-HIV, anti-cancer, anti-helminthic, and other pharmacological activities. Numerous novel nitrogen-based heterocycles have been synthesized, which showed various physiological properties, and their application in medicinal chemistry is ever-growing. The present review will provide an in-depth view of N-heterocyclic compounds that showed biological activities in the last 5 years (2017-2021). This review article will be helpful for the structural design of effective and sustainable N-heterocyclic drugs against diseases with minimal side effects.
β-sitosterol in Various Pathological Conditions: An Update
Authors: Yadav Poonam , Chauhan Chandan , Singh Sanjiv , Banerjee Sugato , Murti Krishna 
Published: December 2021

Abstract:
Phytosteroids are biologically active compounds found naturally in herb plasma membranes,
with a chemical composition similar to animal plasma membrane cholesterol. It can be
found in almost all fats abundant plant’s diets. One of the vital phytosterols is β-sitosterol which
has several biological activities. It has been proved in various in-vivo and in-vitro research in
which β-sitosterol stabilized several physiological activities like as antioxidant, CNS activity (like
anti-alzheimer, anxiolytic and sedative effects, CNS depressant activity), lipid-lowering effects
(like nonalcoholic fatty liver disease), antidiabetic, anti-inflammatory and analgesic effects, anticancer
and immunomodulatory, protective effects in pulmonary fibrosis, wound healing effects and
anti-viral and COVID-19 activity. The experimental research on β-sitosterol shows that it can be
used as a nutritional supplement to combat variousexisting diseases. In this review, we are highlighting
the most significant pharmacological action of β-sitosterol on the basis of available literature.
A Review on Bioactive Constituents of Essential Oils as Mosquito Repellent
Authors: Dutta Rajat Subhra , Sahu Supriya , Mazumder Bhaskar 
Published: December 2021

Abstract:
Currently, the research focus has been on finding new alternatives to synthetic mosquito
repellents due to their toxicity. Natural products act as a suitable alternative since plant-based
mosquito repellents have been used traditionally due to their low toxicity. Essential oils as mosquito
repellent have gained importance due to various functional bioactive constituents. Different formulations
of essential oils have been studied from time to time to enhance the stability and protection
time. However, the underlying mechanism of repellent activity of the bioactive constituents
against specific mosquito species remains unexplored. This review focuses on the various sources
of essential oil with their bioactive components and their receptor-based mechanism of action for
inducing mosquito repellency against different mosquito species. Furthermore, a comparison of the
various formulations of essential oil-based mosquito repellents with synthetic repellents has been
discussed.
Pharmaceutical Lozenges: Recent Trends and Developments with an Update
on Research and Patents
Authors: Kumar Rajesh , Kulkarni Mangesh Pradeep , Sharma Arun , Tanwar Sagar , Vandana Parashara Bhattar , Wadhwa Sheetu , Singh Gurvinder , Kumar Pardeep 
Published: December 2021

Abstract:
Pharmaceutical oral dosage forms are tremendously preferred by both consumers as well
as pharmaceutical manufacturers owing to the plethora of benefits they offer. Lozenges (LZs) are
one of the dosage forms that provide a palatable means of drug administration and have great importance
with respect to their pharmaceutical applications. LZs offer additional benefits to pediatric
and geriatric patients, along with people having problems associated with the gastro-intestinal
tract. Dysphagia is a common problem faced by all age groups, which gives rise to the need for
LZs. Moreover, the foremost merit presented by the medicated LZs includes its augmented retention
time in the oral cavity that results in an enhanced bioavailability for buccal or upper gastro-intestinal
disorders. Further, LZs can also be used to bypass the first-pass effect. The present review
covers various aspects of LZs such as formulation, manufacturing techniques, evaluation parameters,
marketed products, patents, and a compilation of research work that has been done on
lozenges as a delivery system.
An Online International Collaborative Learning Program During the COVID-19 Pandemic for Nursing Students: Mixed Methods Study
Authors: Jung Dukyoo , De Gagne Jennie C , Choi Eunju , Lee Kyuri 
Published: December 2021

Background
Given the limitations imposed by the COVID-19 pandemic, a better understanding of how nursing programs around the globe have implemented distance education methods and related initiatives to provide international collaborative learning opportunities as well as complementary aspects of practical education would be constructive for nursing students. It is expected that international collaboratives through web-based communication will continue to be increasingly utilized after the pandemic; therefore, it is time to discuss the effects and direction of these developments.

Objective
We aimed to examine the impact of an online international collaborative learning program on prelicensure nursing students’ international and global competencies in South Korea.

Methods
We conducted a mixed methods study (web-based surveys and focus group interviews). A total of 15 students participated in the study. The surveys were used to examine changes in participants’ global leadership competencies, and the focus group interviews were used to evaluate the program’s effectiveness and to identify opportunities for improvement. The online international collaborative program consisted of 7 synchronous web-based classroom sessions. Each session ran for 60 to 90 minutes. Faculty experts and nurses working in the United States discussed various topics with students, such as nursing education in the United States and evidence-based teaching and learning. The students gave presentations on the South Korean nursing education system. Data were analyzed with descriptive statistics, the Mann-Whitney U test, and content analysis methods.

Results
Participants reported improvement in their global leadership competencies. Four main categories emerged from analysis of the focus interviews: (1) realistic applicability, (2) clarification, (3) expansion of perspectives, and (4) initiative.

Conclusions
The online international collaborative learning program had a positive impact on the development of students’ international competencies. The findings support the further development of international exchange programs through web-based meetings in the postpandemic era.
Design and Evaluation of a Just-in-Time Adaptive Intervention (JITAI) to Reduce Sedentary Behavior at Work: Experimental Study
Authors: Ismail Tasnim , Al Thani Dena 
Published: December 2021

Background
Employees in sedentary occupations tend to spend prolonged hours physically inactive. Physical inactivity is a main factor in the increase in the risks of a wide range of chronic diseases, including obesity, diabetes, hypertension, and heart disease. This has drawn researchers’ attention to investigate methods of increasing the level of activity of employees during working hours and in their daily lifestyle.

Objective
The objective of this paper is to investigate the effectiveness of using personalized messages that include user information, user goals, daily routine, and the surrounding environment to increase the level of activity among employees. In this study, we hypothesize that sending context-aware motivational messages to workers in sedentary occupations after sitting for 40 minutes can break sedentary behavior and increase daily active time compared to static reminder messages.

Methods
A 66-day between-group study using a mixed methods design approach was conducted with employees who are located in Qatar and spend most of their working day sedentary. The 58 participants used 2 different interventions: The control group (n=29, 50%) used a mobile app that only sends a static message after prolonged sitting (MotiFit Lite), and the intervention group (n=29, 50%) used a mobile app that sends context-aware personalized messages to promote physical activity (PA; MotiFit). Both apps log the received messages, the step count before and after the messages are sent, and the user response to the messages to obtain an idea of the impact of the messages. The study received approval from the Qatar Biomedical Research Institute’s institutional review board (IRB application #2019-10-037).

Results
The questionnaires showed satisfaction of the designed apps’ subjective quality and perceived impact. The quantitative analysis showed a high level of engagement in the intervention group compared to the control group (P<.001). The results support the original hypothesis that using context-aware motivational messages can increase PA at work compared to static messages (P<.001). However, the analysis showed no significant impact of the message type on the overall activity level during the day (P=.06).

Conclusions
Context-aware motivational messages motivate employees to increase their PA in the workplace. However, future research will further develop the analysis to investigate the impact on increasing the overall activity level during the day.
Optimization of Cutting Parameters for Milling Process of (4032) Al-Alloy using Taguchi-Based Grey Relational Analysis
Authors: Hammood Sami Abbas 
Published: December 2021

The objective of this work is to study the influence of end milling cutting process parameters, tool material and geometry on multi-response outputs for 4032 Al-alloy. This can be done by proposing an approach that combines Taguchi method with grey relational analysis. Three cutting parameters have been selected (spindle speed, feed rate and cut depth) with three levels for each parameter. Three tools with different materials and geometry have been also used to design the experimental tests and runs based on matrix L9. The end milling process with several output characteristics is solved using a grey relational analysis. The results of analysis of variance (ANOVA) showed that the major influencing parameters on multi-objective response were spindle speed and cutting tool with contribution percentage (52.75%, 24%), respectively. In addition, the optimum combination of end milling process parameters was then validated by performing confirmation tests to determine the improvement in multi-response outputs. The confirmation tests obtained a minimum (surface roughness and micro-hardness) and maximum metal removal rate with grey relational grade of 0.784 and improvement percentage of 2.3%.
Gambaran Tingkat Latihan Fisik Jemaah Haji sebelum Keberangkatan di Kabupaten Lumajang, Provinsi Jawa Timur, Tahun 2017
Authors: Rudyanto Chandra 
Published: December 2021

Abstract
Adequate health condition urgently required by pilgrims because pilgrimage process involves a very heavy physical activity. Hajj pilgrims with good physical fitness classified as pilgrims who fulfill health istiţā'ah. Participation of pilgrims in a fitness improvement program could be observed through physical exercise behaviour. This study aimed to describe the level of pilgrims’physical exercise in Lumajang District and analyse the relationship between the characteristics, knowledge, and attitudes of the pilgrims with physical exercise. This research used a quantitative method with a cross sectional design. Primary data collected through a survey from 185 respondents. Data analysis was performed using a statistical test of multiple logistic regression. The results showed that most of the pilgrims (61.8%) had high knowledge of physical exercise. More than 86 % of pilgrims have a supportive attitude towards physical exercise. In conclusion, this study found there was no significant relationship between knowledge and attitudes with physical exercise (p>0.05). Participation in physical exercise of pilgrims showed that 12,9% of pilgrims have a good and very good level of physical exercise. Physical exercise behavior provides an indication of the active participation of pilgrims in hajj health improvement program before departure. It was recommended that the the measurement of the level of physical exercise that took into account the factors of frequency, duration and intensity could be part of the policy on hajj health management in Indonesia.
VIVÊNCIAS E PRÁTICA PEDAGÓGICA DO BALÉ CLÁSSICO DE PROFESSORES DA CIDADE DO RECIFE/PE
Authors: Lopes Juliana Siqueira , Oliveira Viviane Maria Moraes de , Guimarães Maria Cláudia Alves , Lima Luciane Soares de 
Published: December 2021

O objetivo do estudo foi compreender a formação específica de professores da cidade do Recife para o exercício docente em balé clássico e como as vivências desses profissionais, enquanto alunos ou bailarinos, influenciaram suas práticas pedagógicas. Foi realizado um estudo descritivo, exploratório e qualitativo, em que foram entrevistados 14 professores. Os dados foram submetidos à análise de conteúdo e os resultados indicaram uma prática pedagógica baseada em distintas formas de conhecimento, além da importância de vivenciar no corpo o que se ensina e como isto repercute na atividade docente, resultando em reprodução e/ou transformação da experiência. Concluiu-se que a abordagem dos professores se baseou mais na prática que na teoria, através de suas vivências como alunos, embora o conhecimento científico tenha sido considerado importante subsídio para o ensino do balé clássico.
Antropologias, artes e política: engajamentos e encontros
Authors: Raposo Paulo 
Published: December 2021

Este artigo explora as modalidades de engajamento que a disciplina antropológica tem vindo experimentar, e em particular, seguindo um percurso pessoal da minha atividade como antropólogo e cidadão, procura dar conta da produção de um certo tipo de antropologia pública. Tomo como ponto de partida a perceção de que todo o conhecimento é, para além de situado, político, uma vez que a produção ou o enquadramento do conhecimento tem sempre efeitos políticos. Para ilustrar esse debate proponho partilhar as estratégias e os itinerários utilizados na realização de três encontros internacionais que buscaram cruzamentos entre arte, antropologia e ativismo e que visavam conjugar tanto artistas quanto pesquisadores, num pano de fundo ligado a uma cidadania engajada. Palavras-chave: Antropologia Pública. Arte. Ativismo. Antropologia engajada. Anthropologies, arts and politics: engagements and encounters Abstract: This article explores the modes of engagement of anthropology that anthropology has been experiencing, and in particular, following a personal journey of my activity as an anthropologist and citizen, seeks to account for the production of a certain type of public anthropology. I take as my starting point the perception that all knowledge is political, besides being situated, since the production or framing of knowledge always has political effects. To illustrate this debate, I propose to share the strategies and itineraries used in the realization of three international meetings that sought intersections between art, anthropology and activism and that aimed to conjugate both artists and researchers, in a backdrop linked to an engaged citizenship.Keywords: Public Anthropology. Art. Activism. Engaged Anthropology.
Perbandingan Algoritma Greedy Dan Metode Branch And Bound Pada Penyelesaian Knapsack 0-1 Untuk Mengoptimalkan Muatan Barang
Authors: Wungguli D , Ibrahim S S , Yahya L 
Published: December 2021

Penelitian ini dilakukan untuk menentukan muatan barang yang akan dijual dengan menggunakan media muatan yang memiliki kapasitas terbatas dalam memperoleh keuntungan maksimum. Data yang digunakan yaitu berupa berat barang, keuntungan, dan kapasitas maksimum media muatan. Selanjutnya dilakukan perhitungan berupa berat total dan keuntungan total dari setiap barang kemudian dimodelkan kedalam bentuk matematika. Metode yang digunakan dalam penelitian ini yaitu algoritma greedy dan metode branch and bound. Diperoleh beberapa solusi optimal dalam menggunakan algoritma greedy yaitu greedy by weight, greedy by profit, dan greedy by density. Hasil penilitian menunjukkan bahwa dengan menggunakan algoritma greedy diperoleh hasil yang maksimal pada perhitungan greedy by profit dengan keuntungan yaitu Rp13952000 dan berat total 15319Kg Sedangkan menggunakan metode branch and bound diperoleh keuntungan Rp141689000 dengan berat total 15599Kg.
Peramalan Harga Emas Menggunakan Metode Average Based And Fuzzy Logic Relationship
Authors: Pratiwi A M , Musdalifah S , Lusiyanti D 
Published: December 2021

Emas merupakan alternatif yang cenderung dipilih kebanyakan orang untuk berinvestasi karena beberapa alasan, salah satunya menguntungkan. Untuk memperoleh keuntungan yang optimal, pelaku investasi harus mengetahui pergerakan harga emas sehingga pelaku investasi tahu kapan harus membeli emas dan kapan harus menjual emas. Pergerakan harga emas dapat dipantau dengan peramalan. Metode peramalan yang digunakan dalam penelitian ini adalah average based and fuzzy logic relationship yang merupakan salah satu metode dengan konsep fuzzy logic. Metode tersebut memberikan tingkat akurasi yang dihitung menggunakan MAPE (Mean Absolute Percentage Error) sebesar Hasil penelitian menunjukkan bahwa peramalan pergerakan harga emas pada bulan Oktober 2020 Desember 2021 dalam rentang harga dengan harga emas tertinggi terjadi pada bulan Desember 2020.
Detailed three-dimensional orthodontic tooth repositioning to improve restorative outcome:
Authors: Mirabella Davide , Macca Ugo , Pancari Carolina , Giunta Gabriella , Lombardo Luca 
Published: December 2021

ABSTRACT
The case describes the interdisciplinary treatment of a 23-year-old woman with a Class III malocclusion, missing an upper right lateral incisor, abrasion of the maxillary incisal edges, anterior gingival margin discrepancies, and gingival recession. Initially, the patient was treated with fixed appliances combined with orthognathic surgery. The extraction of the upper left lateral incisor and bilateral canine substitution plan was chosen. At the end of the surgical and orthodontic treatment, the restorative treatment with six veneers was accomplished to improve smile esthetics. Despite the missing lateral incisors, the patient showed a natural, good-looking final result. A symmetric incisal plane was established, a functional occlusion with average vertical and horizontal overlap was set, and the bone scallop and consequently the gingival margins were leveled. The interdisciplinary approach hid all of the initial esthetic defects of the case. The result highlights how to obtain a remarkable improvement of the smile outcome with a well-functioning masticatory system.