bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating glomerular filtration rate via cystatin C in preterm infants: a comparative analysis
Authors: Coskun Yesim , Demirel Ozlem Unay , Bayram Tevfik , Akman Ipek , Hacihamdioglu Duygu Ovunç 
Published: September 2022

Background: We aimed to determine the course of serum creatinine (sCr), serum cystatin C (sCysC) and urine cystatin C (uCysC) levels and calculate estimated glomerular filtration rate (eGFR) by using sCr- and sCysC-based formulas in preterm infants in the first 28 days of life.
Methods: A total of 52 neonates were included in this prospective study. According to gestational age (GA), the neonates were divided into three groups. Group 1 composed of neonates who were born â‰¤28 weeks (n=15), group 2 and 3 consisted of infants who were born 29-31 weeks (n=16) and 32-34 weeks (n=21), respectively. Blood and urine samples were obtained at the 24-48 hours of life and then weekly until 28th day of life. sCr- and sCysC-based formulas were applied to determine the value and course of eGFR.
Results: sCr level was negatively correlated with GA (r=-0.36, p=0.014) but not with BW (r=-0.15, p=0.31). While sCr levels showed significant variations in all study groups on day 7, day 14, and day 21 however, sCysC did not differ by GA at any time-points. All study groups had significantly different uCysC levels, except day 28. eGFR results calculated with sCr-based formula were detected to be closer to inulin.
Conclusion: In preterm infants, sCr seemed to be a more reliable marker than sCysC to calculate eGFR. Moreover, in the same population, uCysC levels may reflect renal maturation more than sCysC.
Antimicrobial activity of homemade WHO ethanol-based hand rub solution in pediatric department, Dr. Cipto Mangunkusumo National Referral Hospital
Authors: Putri Nina Dwi , Satari Hindra Irawan , Karyanti Mulya Rahma , Prayitno Ari , Wicaksana Pratama , Karuniawati Anis , Lestari Delly Chipta , Salma Nabila Maudy , Aprianti Shindy Claudya , Almira Amalia , Khafiyani Andi Annisa Rusyda 
Published: September 2022

Background Hand hygiene is essential in reducing healthcare-associated infections. Alcohol-based hand rub solutions have been reported to have superior antimicrobial efficacy on both bacteria and lipophilic viruses compared to washing with hand soap. In low- and middle-income countries, the cost of infection control poses a challenge. Our hospital produced an ethanol-based hand rub based on a WHO formulation to reduce the infection prevention costs.
Objectives To identify the antimicrobial activity of a WHO ethanol-based hand rub solution against bacterial contamination on the hands of healthcare workers at the Department of Child Health, Dr. Cipto Mangunkusumo National Referral Hospital.
Methods This cross-sectional study was performed on the hands of healthcare workers (physicians and nurses) working in the Department of Child Health, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta. A total of 225 specimens from 75 subjects were obtained by collecting swabs on both hands before and after participants worked in the Department of Child Health, Dr. Cipto Mangunkusumo General Hospital. Bacterial culture tests were performed to identify gram-positive and gram-negative bacteria. Bacteria were grouped into no-growth/Bacillus sp, Enterobacteriaceae, cocci, and non-fermenter groups.
Results The use of our WHO ethanol-based hand rub solution, generally resulted in a statistically significant decrease in bacterial growth from 84 to 54.6%, before compared to after the hand rub was performed. In more detail, there was a 72.7% decrease in Enterobacteriaceae, a 71.4% decrease in non-fermenters, an 8.6% decrease in cocci and a 44.1% increase in the number of specimens showing no growth bacteria/Bacillus sp.
Conclusion Our WHO ethanol-based hand rub has significant antimicrobial activity for common nosocomial pathogens (e.g., Staphylococcus aureus, P. aeruginosa, and K. pneumoniae).
De Novo Diagnosis of Lymphocytic Colitis After SARS-CoV-2 Vaccination
Authors: Lee Preston , Wei Mike T. , Gubatan John , Forgó Erna , Berry Gerald J. , Verma Rahul , Friedland Shai 
Published: September 2022

ABSTRACT
SARS-CoV-2 mRNA vaccines are safe and effective for most patients. Gastrointestinal complications reported after vaccination have included gastroparesis and inflammatory bowel disease flares. In this study, we present a unique case of lymphocytic colitis that occurred in a healthy middle-aged man after Moderna SARS-CoV-2 mRNA vaccination. This reveals an unexpected complication of a mRNA vaccine that presented as worsening diarrhea after vaccination in a dose-dependent pattern. Caregivers should be aware of lymphocytic colitis as a possible complication of the Moderna vaccine and monitor those patients closely for symptom resolution.
Resistensi Pembangunan dan Lahan di Indonesia Demi Terwujudnya Keadilan dan Kesejahteraan Bagi Seluruh Rakyat Indonesia
Authors: Handoko Rais Firdaus 
Published: September 2022

Hukum adalah pedoman untuk bersikap dan bertingkah laku.Dibentuknya hukum bertujuan untuk menciptakan kedamaian dalam kehidupan (di dalam kedamaian terdapat kesejahteraan, ketertiban, dan keadilan) masyarakat. Untuk membentuk hukum, diwajibkan menggali nilai-nilai dan norma-norma di dalam masyarakat. Jika hal tersebut dapat tercapai maka tercapailah yang disebut hukum responsif, yaitu hukum yang sesuai dengan keinginan dan substansi dalam masyarakat, sehingga hukum diciptakan untuk manusia, bukan manusia diciptakan untuk tunduk terhadap hukum. Pembentukan hukum seringkali belum berjalan seperti yang diharapkan (das sollen), karena pembentukan hukum sering dipengaruhi oleh kepentingan politik suatu kaum masyarakat.Hukumdan politik bagaikan dua sisi mata uang logam, yang mana mempunyai wajah (fisik) yang berbeda, tetapi tidak dapat dipisahkan.Dari adanya politik suatu kaum masyarakat membuat hukum tidak untuk kepentingan bersama, maka terkadang timbul aturan yang tidak pro-rakyat. Pembangunan tidak seluruhnya bersifat negatif, tetapi pembangunan yang tidak ada pembatasan, tidak akan memunculkan keadilan dalam masyarakat. Pada dasarnya manusia memiliki karakter homo homini lupus (manusia serigala untuk manusia lainnya) sehingga tidak seluruh pembangunan ditujukan untuk kemakmuran bersama, terlebih juga suatu pembangunan pasti memiliki tujuan (kepentingan). Kepentingan-kepentingan kelompok suatu kaum masyarakat memunculkan kelompok masyarakat yang kuat dan lemah.Kelompok masyarakat kuat muncul pula yang pro-rakyat dan tidak pro-rakyat. Kelompok kuat cenderung memiliki akses terhadap aparatus negara, sehingga pemilik modal yang neo-liberal tampil sebagai kekuatan sosial dominan, sehingga perlu di resistensi agar menimbulkan kepastian, evaluasi (kemanfaatan), dan keadilan.Kata kunci: Resistensi, Das Sollen, Pembangunan.
Mengurai Perempuan dan Pembangunan (Studi Kasus Kartini Kendeng)
Authors: Rajagukguk Samuel B. T. 
Published: September 2022

Sudah hampir 3 (tiga) tahun, Indonesia khususnya masyarakat Pegununan Kendeng di Jawa Tengah dihadapkan pada persoalan bagaimana sebenarnya konsep yang tepat dalam merumuskan masyarakat yang dicita-citakan. Tidak lebih perdebatannya adalah siapa yang akan merumuskan ataupun mendeskripsikan masyarakat ideal. Hal ini dihadapkan pula oleh kekuasaan dan sifat mendasar dari manusia Indonesia itu sendiri. Definisi pembangunan guna mencapai masyarakat yang dicitakan menjadi program sentral pemilik modal, kuasa, dan budaya-budaya Patriarki manusia Indonesia. Masyarakat kecil termajinalkan, masyarakat adat dihilangkan, kaum minoritas dianggap tidak ada, hingga persoalan lainnya. Tebakannya adalah mungkin saja Indonesia masih proses menjadi. Tetapi, nilai fundamentalnya adalah menjadi apa, konsep kaum urbankah, pandangan kaum andropsentriskah, atau lainnya untuk mencapai masyarakat yang inginkan. Bidang pertambangan dan industrialisasi sering kali yang menjadi korban adalah perempuan. Apakah dalam pengetahuan perempuan menolak pertambangan dan/atau industrialisasi.Kata Kunci: Pembangunan, Pertambangan, Industrialisasi, Perempuan.
Logistic damping effect in chemotaxis models with density-suppressed motility
Authors: Lyu Wenbin , Wang Zhi-An 
Published: September 2022

Abstract
This paper is concerned with a parabolic-elliptic chemotaxis model with density-suppressed motility and general logistic source in an n-dimensional smooth bounded domain with Neumann boundary conditions. Under the minimal conditions for the density-suppressed motility function, we explore how strong the logistic damping can warrant the global boundedness of solutions and further establish the asymptotic behavior of solutions on top of the conditions.
Flexural strength and thermal properties of carbon black nanoparticle reinforced epoxy composites obtained from waste tires
Authors: Öner Gülşah Alar 
Published: September 2022

Abstract
In this study, both mechanical and thermal properties of epoxy@carbon black nanocomposite (EP@CB-NC) produced by adding 0.3, 0.6, and 1% by weight carbon black nanoparticle obtained from waste automobile tires to epoxy were investigated. The chemical and structural composition of EP@CB-NC was characterized by Fourier transform infrared spectroscopy (FTIR) in scanning electron microscopy (SEM). In addition, simultaneous thermo-gravimetric analysis (TGA), differential scanning calorimetry (DSC) experiments, and thermal conductivity measurements were performed to determine the thermal stability of the prepared EP@CB-NC. Increasing the strength of modified epoxy composites by means of nanoparticles obtained with waste may pave the way for obtaining new materials with clean environment and superior properties. The mechanical and thermal properties were improved by adding carbon black to the bare samples.
On synthesis of reversible circuits consisting of NOT, CNOT, 2-CNOT gates with small number of additional inputs
Authors: Zakablukov Dmitry V. 
Published: September 2022

Abstract
Reversible circuits consisting of NOT, CNOT and 2-CNOT gates with small number of additional inputs are considered. For such a circuit implementing a map

f
:

Z

2
n

→

Z

2
n

,

$f\colon \mathbb Z_2^n \to \mathbb Z_2^n,$

we study the Shannon complexity function L(n, q) under the condition that the number of additional inputs is q = O(n
2). For this range of q, it is shown that

L
(
n
,
q
)
≍
n

2
n

/

log
2

n
.

$L(n,q) \asymp n2^n \mathop / \log_2 n.$

We show that

L
(
n
,
q
)
≍
n

2
n

/

log
2

(
n
+
q
)

$L(n,q) \asymp n2^n \mathop / \log_2 (n+q)$

for all

q
≲
n

2

n
−
⌈
n

/

ϕ
(
n
)
⌉

,

$q \lesssim n2^{n-\lceil n \mathop / \phi(n)\rceil},$

where

ϕ
(
n
)
→
∞

and

n

/

ϕ
(
n
)
−

log
2

n
→
∞

as

n
→
∞
.

$\phi(n) \to \infty {\text {and}} \,n \mathop / \phi(n) - \log_2 n \to \infty \,{\text {as}}\, n \to \infty.$
Landuma: a case of radical alliterative agreement
Authors: Sumbatova Nina 
Published: September 2022

Abstract
The principal goal of this paper is to describe agreement in the Landuma language (Mel < Niger-Congo). Landuma shows agreement in animacy and, for inanimate nouns, radical alliterative agreement, a type of agreement conditioned by phonology: the first phoneme of the agreement prefix is conditioned by the first phoneme of the controlling noun. This type of agreement has much in common with agreement in noun class but is governed by essentially different mechanisms. Radical alliterative agreement is a challenge for linguistic theory, because it contradicts the generally adopted Principle of Phonology-Free Syntax and the understanding of phonological elements as unilateral entities. Radical alliterative agreement has been previously found in some other languages, first of all in the Kru languages (Niger-Congo) and in the Arapesh languages (New Guinea). The authors who have dealt with radical alliterative agreement have suggested a number of alternative descriptions in order to avoid theoretical problems. Some of the possible alternatives are also discussed in this paper.
Geoid model validation and topographic bias
Authors: Sjöberg Lars E. 
Published: September 2022

Abstract
Recently a number of geoid campaigns were performed to verify different types of geoid and quasigeoid modeling techniques. Typically, GNSS-leveling was employed as an independent method, but in some cases zenith camera astronomic deflection data were also used in astrogeodetic determinations of the geoid and/or quasigeoid. However, due to the uncertainty in the topographic density distribution data (and thereby in orthometric heights), we conclude that neither GNSS-leveling nor astrogeodetic techniques can reliably verify differences between gravimetric geoid models at several centimeter levels in rough mountainous regions. This is because much the same topographic data are used both in the gravimetric geoid models and in their verifications by geometric and/or astrogeodetic geoid models. On the contrary, this is not a problem in verifying gravimetric quasigeoid models, as they are independent of the topographic density distribution, and so is the related normal height used in GNSS-leveling.
{6,6′-((1E,1′E)-((2,2-dimethylpropane-1,3-diyl)bis(azaneylylidene))bis(methaneylylidene))bis(2-bromo-4-chlorophenolate)-κ4N,N′,O,O′}copper(II), C19H16Br2Cl2CuN2O2
Authors: Wu Qiong , Yu Guojun , Yang Jiao , Yang Qiuling 
Published: September 2022

Abstract
C19H16Br2Cl2CuN2O2, monoclinic, P21/n (no. 14), a = 12.4679(2)Å, b = 8.61760(10) Å, c = 19.7854(3) Å, β = 97.1610(10)°, V = 2109.23(5) Å3, Z = 4, R

gt
(F) = 0.0325, wR

ref
(F
2) = 0.0865, T = 170.0 K.
[2,2′-{Ethane-1,2-diylbis[(azanylylidene)methanylylidene]}bis(3-bromo-2-hydroxyphenyl)]iron(III) nitrate, C20H12Br2CuN2O2
Authors: Yang Jiao , Xu Jiajun , Liao Nichan , Wu Qiong 
Published: September 2022

Abstract
C20H12Br2CuN2O2, orthorhombic, Pbca (no. 61), a = 7.7117(2) Å, b = 18.7735(4) Å, c = 24.8518(4) Å, V = 3597.93(13) Å3, Z = 8, Rgt
(F) = 0399, wRref
(F
2) = 0.1125, T = 213 K.
The crystal structure of [(2,2′-bipyridine-κ2
N,N)-bis(6-phenylpyridine-2-carboxylato- κ2
N,O)nickel(II)] monohydrate, C34H26N4O5Ni
Authors: Tingting Zhou , Zhen Cao 
Published: September 2022

Abstract
C34H26N4O5Ni, monoclinic, C2/c (no. 15), a = 29.3459(13) Å, b = 10.2867(4) Å, c = 19.8780(9) Å, β = 107.243(5)°, V = 5730.9(4) Å3, Z = 8, Rgt
(F) = 0.0326, wRref
(F
2) = 0.0817, T = 200K.
Rechtliche Gestaltungsmöglichkeiten der Purpose Economy im Gesundheitswesen
Authors: Hoffmann Felix , Schumacher Helge 
Published: September 2022

Zusammenfassung
Seit einigen Jahren werden die Stimmen lauter, die die zunehmende Kommerzialisierung des Gesundheitswesens kritisieren. Die sogenannte Purpose Economy ist ein vielversprechender Ansatz für eine alternative privatwirtschaftliche Herangehensweise an die Art und Weise des Wirtschaftens. Anhand dieses Artikels wird zunächst eine Definition des Begriffes „Purpose Economy“ hergeleitet, um dann rechtliche Gestaltungsmöglichkeiten der Purpose Economy im Gesundheitswesen darzustellen.
Patientenpräferenzen in AMNOG-Nutzenbewertungen: Anspruch und Wirklichkeit
Authors: Hipp Wolfgang 
Published: September 2022

Zusammenfassung
Die Bewertung patientenrelevanter therapeutischer Effekte bildet den Kern der AMNOG-Nutzenbewertungen. Die Antworten des Gemeinsamen Bundesausschusses auf die entscheidende Frage der Patientenrelevanz klinischer Endpunkte sind bisher wenig evidenzbasiert. Es gibt vielversprechende Initiativen, das ungenutzte Potenzial der Erhebung von Patientenpräferenzen zur systematischen Bestimmung der Patientenrelevanz auszuschöpfen.
Proteomics characterization of the adenovirus VA1 non-coding RNA on the landscape of cellular proteome
Authors: Uddin Zafar , Khan Munazza , Höti Naseruddin , Khan Jabbar , Attar Roba 
Published: September 2022

Abstract

Objectives
Gene therapy using adenoviruses has shown tremendous promise in animal and human models in the past. The tumor responses achieved by these viruses were either because of their oncolytic properties or therapeutic genes expressed from the genome of the virus. We have previously shown enhanced viral replication in cell models that have lost or lower expression of the cyclin dependent kinases inhibitor (p21/Waf-1). Beside the early onset of many viral genes in the p21/Waf-1 knock out cell model, we observed a significantly higher copy number for the viral VA1 but non VA2 non-coding RNA transcripts. In this study we investigated the effect of adenoviral VA1 non-coding RNA on the landscape of cellular proteins.

Methods
Using a DU145 cell line as a model that was transiently transfected with a plasmid carrying the adenoviral VA1 non-coding RNA, we were able to study changes in the proteome and the cellular cascade of the cells. Using state of the art global proteomics analyses of the differentially expressed proteins between the VA1 overexpressed and control cells demonstrated how the early onset of VA1 transcript affected cellular machinery.

Results
Using a 1.5 fold cut off between the down-regulated or overexpressing proteins, we were able to demonstrate how the non-coding VA1 gene might be responsible for suppressing the proteasome degradation, the endocytic and lysosomal pathways. Similarly, overexpression of the non-coding VA1 transcript was responsible for the upregulation (1.5 fold) of approximately 40 different proteins in the spliceosome machinery.

Conclusions
These data demonstrated how the non-coding VA1 RNA functioned independently of any other viral proteins in modulating the cell signaling cascades to promote viral propagation. To our knowledge this is the first report to investigate the function of VA1 non-coding RNA on the cellular proteome.
Sistemas eleitorais e integridade eleitoral
Authors: Rebouças Batista Ian , Lins Rodrigo 
Published: September 2022

O que são sistemas eleitorais, como variam ao redor do mundo e quais as suas consequências para outros elementos da vida política de um país? Este artigo busca refletir sobre essas questões de maneira didática, percorrendo as principais famílias de sistemas eleitorais – majoritário, proporcional e misto – e variações dentro destas. Demonstramos ainda que sistemas eleitorais específicos não geram necessariamente eleições melhores ou piores. Com dados do International Institute for Democracy and Electoral Assistance e do Electoral Integrity Project mostramos que ainda que eleições com sistemas proporcionais apresentem consistentemente melhores índices de integridade eleitoral, isso não se dá em razão do sistema eleitoral em si, mas um elemento anterior influencia tanto a adoção de determinado sistema quanto na qualidade da eleição: a qualidade do regime. Autocracias, que por definição realizam eleições enviesadas, onde o incumbente não pode perder, adotam sistemas majoritários com maior frequência, enquanto democracias, que realizam eleições competitivas, adotam mais frequentemente o sistema proporcional.
A Gap-Junction Mutation Reveals That Outer Hair Cell Extracellular Receptor Potentials Drive High-Frequency Cochlear Amplification
Authors: Levic Snezana , Lukashkina Victoria A. , Simões Patricio , Lukashkin Andrei N. , Russell Ian J. 
Published: September 2022

Cochlear amplification enables the enormous dynamic range of hearing through amplifying cochlear responses to low- to moderate-level sounds and compressing them to loud sounds. Amplification is attributed to voltage-dependent electromotility of mechanosensory outer hair cells (OHCs) driven by changing voltages developed across their cell membranes. At low frequencies, these voltage changes are dominated by intracellular receptor potentials (RPs). However, OHC membranes have electrical low-pass filter properties that attenuate high-frequency RPs, which should potentially attenuate amplification of high-frequency cochlear responses and impede high-frequency hearing. We madein vivointracellular and extracellular electrophysiological measurements from the organ of Corti of male and female mice of the CBA/J strain, with excellent high-frequency hearing, and from the CD-1 mouse strain, which has sensitive hearing below 12 kHz but loses high-frequency hearing within a few weeks postpartum. The CD-1 mouse strain was transfected with an A88V mutation of the connexin 30 gap-junction protein. By blocking the action of the GJ protein to reduce input resistance, the mutation increased the OHC extracellular RP (ERP) magnitude and rescued high-frequency hearing. However, by increasing the organ of Corti resistance, the mutation rescued high-frequency hearing through preserving the OHC extracellular RP (ERP) magnitude. We measured the voltage developed across the basolateral membranes of OHCs, which controls their electromotility, for low- to high-frequency sounds in male and female mice of the CD-1 strain that expressed the A88V mutation. We demonstrate that ERPs, not RPs, drive OHC motility and cochlear amplification at high frequencies because at high frequencies, ERPs are not frequency attenuated, exceed RPs in magnitude, and are appropriately timed to provide cochlear amplification.SIGNIFICANCE STATEMENTCochlear amplification, which enables the enormous dynamic range of hearing, is attributed to voltage-dependent electromotility of the mechanosensory outer hair cells (OHCs) driven by sound-induced voltage changes across their membranes. OHC intracellular receptor potentials are electrically low-pass filtered, which should hinder high-frequency hearing. We measured the intracellular and extracellular voltages that control OHC electromotilityin vivoin a mouse strain with impaired high-frequency hearing. A gap-junction mutation of the strain rescued high-frequency hearing, increased organ of Corti resistance, and preserved large OHC extracellular receptor potentials but reduced OHC intracellular receptor potentials and impaired low-frequency hearing. We concluded intracellular potentials drive OHC motility at low frequencies and extracellular receptor potentials drive OHC motility and cochlear amplification at high frequencies.
Examining the Association Between MIS-C and the Child Opportunity Index at a Single Center
Authors: Tyris Jordan , Boggs Kaitlyn , Bost James , Dixon Gabrina , Gayle Tamara , Harahsheh Ashraf S. , Sharron Matthew P. , Majumdar Suvankar , Krishnan Anita , Smith Karen , Goyal Monika K. , Parikh Kavita 
Published: September 2022

OBJECTIVE
To describe associations between the Child Opportunity Index (COI) and multisystem inflammatory syndrome of childhood (MIS-C) diagnosis among hospitalized children.

METHODS
We used a retrospective case control study design to examine children ≤21 years hospitalized at a single, tertiary care children’s hospital between March 2020 and June 2021. Our study population included children diagnosed with MIS-C (n = 111) and a control group of children hospitalized for MIS-C evaluation who had an alternative diagnosis (n = 61). Census tract COI was the exposure variable, determined using the patient’s home address mapped to the census tract. Our outcome measure was MIS-C diagnosis. Odds ratios measured associations between COI and MIS-C diagnosis.

RESULTS
Our study population included 111 children diagnosed with MIS-C and 61 children evaluated but ruled out for MIS-C. The distribution of census tract overall COI differed significantly between children diagnosed with MIS-C compared with children with an alternate diagnosis (P = .03). Children residing in census tracts with very low to low overall COI (2.82, 95% confidence interval [CI]: 1.29–6.17) and very low to low health/environment COI (4.69, 95% CI 2.21–9.97) had significantly higher odds of being diagnosed with MIS-C compared with children living in moderate and high to very high COI census tracts, respectively.

CONCLUSION
Census tract child opportunity is associated with MIS-C diagnosis among hospitalized children suggesting an important contribution of place-based determinants in the development of MIS-C.