bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pregnancy preparation: redistribution of CCR7-positive cells in the rat uterus
Authors: Thomas Hannah , McCloskey Erick , Rider Virginia 
Published: August 2022

In brief
Changes in the endometrium prior to implantation may be critical in predicting pregnancy outcomes. This study shows that the endocrine system directs positional changes in CCR7+ cells before implantation, which may be critical for developing maternal tolerance.

Abstract
Suppression of the maternal immune system is vital for the implantation of the semi-allogeneic embryo. Although progress in understanding the dialogue between mother and embryo has been made, key interactions between maternal immune cells, hormones, and chemokines remain elusive. Uterine expression of the C-C chemokine receptor type 7 (CCR7) could recruit T regulatory cells and facilitate localized immune suppression. To test this concept, Ccr7 mRNA and protein were assessed in uterine tissue. Ccr7 mRNA expression peaked at day 4 in pregnant rat uteri and then declined at days 5 and 6. CCR7 protein showed similar quantitative changes. To test if female sex steroids affected the spatial distribution of CCR7-expressing cells, uteri from ovariectomized rats, progesterone-pretreated rats (2 mg daily), and progesterone-pretreated rats injected with estradiol (0.2 µg) were analyzed. Progesterone increased CCR7-positive (+) cells in the antimesometrial stroma. Progesterone and estradiol increased CCR7+ cells in the mesometrial stroma. Estradiol increased the density of cluster of differentiation 4 (CD4) positive cells in the mesometrial stromal region over progesterone alone. The density of cells expressing the T regulatory cell marker, forkhead box protein 3 (FOXP3), increased in the antimesometrial stroma in response to progesterone alone. Progesterone and estradiol increased FOXP3+ cells in the antimesometrial region of the stroma. Co-localization of CCR7, CD4, and FOXP3 in the stroma suggests CCR7+ cells are T regulatory cells. Polarization of CCR7+ cells in the endometrial stroma was an intrinsic response regulated by sex steroids and did not require the presence of an embryo.
Hormonal background in young men with epilepsy: the influence of pathology and treatment
Authors: Voitiuk Anna 
Published: August 2022

The study examined the effect of some antiepileptic medications and the disease itself on the hormonal background of young men.
The aim of the study was to examine the effect of some antiepileptic drugs and the disease itself on the hormonal background of young men.
Methods: This study involved 80 male patients aged 18-44 years. All patients were divided into 4 groups depending on the monotherapy received: carbamazepine (CBZ), valproic acid (VA), levetiracetam (LEV) and oxcarbazepine (OXC). Twenty healthy males aged 18-44 years (31.30 ± 4.07), who met the inclusion criteria, were included in the study as a control group. Venous blood samples (5 mL) were collected in heparinized tubes between 07:00 and 08:00 am after a fasting period of 8 hours for measurement of serum hormones. The levels of estradiol, progesterone, testosterone, and prolactin were determined by chemiluminescence analysis.
Results: epilepsy and sexual hormones abnormalities are strictly linked. Moreover, the use of many ASMs (in particular, CBZ, VPA, LEV and OXC) can contribute to these abnormalities in men with epilepsy. Over time, these alterations may result in diminished potency and fertility.
Conclusions: the ASMs' therapy may lead to dysregulation of sex hormones and sexual dysfunction in male patients with epilepsy. The use of the liver enzyme inducing AEDs, such as carbamazepine, which increases serum sex hormone binding globulin (SHBG) concentrations. This increase leads to diminished bioactivity of testosterone, which may result in diminished potency and thus reduced fertility. Men taking valproic acid have significantly higher dehydroepiandrosterone levels and lower gonadotropin concentration. This must be considered for the selection of antiepileptic drugs in young male patients. However, the effect of both the disease itself and ASMs’ therapy on hormones in young men requires further research
Correlation of fine needle aspiration cytology with histopathological findings in the diagnosis of thyroid swellings
Authors: Sheeja Jabamalai , Sangeetha Nagalingam , Saranya Bai Selvaraj 
Published: August 2022

The aim of the study: the present study is to evaluate the accuracy of fine needle aspiration cytology (FNAC) of thyroid swellings and to correlate with histopathological findings to avoid unnecessary surgeries for benign lesions.
Methods: this is a prospective study. A total of 55 cases were studied in the Department of Pathology at A.C.S Medical College and Hospital. Fine needle aspiration cytology was done and correlated with histopathological examination. Sensitivity, specificity, and accuracy were calculated.
Results: majority were noted among 41-50 years (60 %). Females i.e., 78.1 % (43/55) outnumbered males 21.8 % (12/55). Solitary nodule thyroid in Right lobe is 54.5 % (30/55) and left lobe is 45.4 % (25/55). In the present study 65.4 % (36/55) presented with symptoms for 1month – 1 year. Non neoplastic lesions constituted 76.3 % (42/55) in our study on FNAC. Among non-neoplastic lesions, nodular goiter was most reported and constituted 36.6 % (20/55). Neoplastic lesions constituted 23.6 % (13/55) and among neoplastic lesions follicular neoplasm occupied 9.09 % (05/55). Nodular goiter was most reported and constituted 29.0 % (17/55). Follicular adenoma occupied 20 % (11/55), 9.09 % (05/55) as PTC and 5.4 % (02/55) reported as follicular carcinoma. 1.8 % (01/55) each reported as medullary carcinoma and anaplastic carcinoma. Non-neoplastic lesions constituted 76.3 % (42/55) in our study on FNAC and neoplastic lesions constituted 23.6 % (13/55).
Conclusion: FNAC is a minimally invasive, highly accurate and cost-effective procedure. FNAC helps the clinician to diagnose malignant lesions with confidence. It has high rates of specificity and accuracy but comparatively has less sensitivity to diagnose the solitary thyroid nodule. However, it is an important diagnostic tool for further management of patients with thyroid swelling
Study of association of diabetic retinopathy with dyslipidemia in type II diabetes mellitus
Authors: Yelamanchili Pasumarthi Pavani , Kurakula Madhuri , Kiranmayi Puwala Sai , Viswanath Kelluru 
Published: August 2022

Diabetic retinopathy is the leading cause of visual disability in the working-age population of industrialized countries. It is considered the hallmark of generalized microangiopathy occurring in a diabetic patient.
The aim: association of Diabetic Retinopathy and CSME with mean values of lipids and Association of the pattern of hard exudates in the fundus in patients with Diabetic retinopathy with or without CSME with mean values of lipids.
Materials and methods: 320 eyes of 160 urban diabetic patients who were seen at the OPD, at Pushpagiri Eye Institute, Secunderabad having diabetic retinopathy were included in the study. Detailed history was taken to note the duration of diabetes, hypertension, history of CAD, CVA, CKD. Patients with duration of diabetes >=5 years were enrolled. Thorough work up was done with slit lamp and indirect ophthalmoscope and posterior segment was examined to evaluate the stage of diabetic retinopathy and presence or absence of CSME. Patients with DR were investigated for Fasting Lipid Profile and HbA1c.
Results: a total of 320 eyes of 160 patients were included in the study. In patients with CSME, mean values of Total Cholesterol, Triglycerides, LDL, HDL, VLDL were higher in the plaque pattern of hard exudates in the macula compared to Discrete and Circinate. There was a statistically significant difference between the mean values of total cholesterol (p=0.00), triglycerides (p =0.035), ldl(p=0.00) in discrete and plaque patterns. There was slightly higher prevalence of PDR among hypertensives compared to non-hypertensives. There was no significant association between DR stage and hypertension(p=0.628). The correlation between CSME and BCVA could not be determined accurately due to the presence of cataract in most of the patients.
Conclusion: this study demonstrated that, diabetic retinopathy is not associated with lipid profile whereas there is statistically significant correlation between mean values of total cholesterol, triglycerides, LDL, VLDL and clinically significant macular edema (CSME)
Characteristics of the degrees of severity of the course of acute intestinal infection in elderly patients with COVID-19
Authors: Shostatska Mariia 
Published: August 2022

The article discloses the characteristics of the degrees of severity of acute intestinal infection in elderly and senile patients with COVID-19.
The aim of the article is to substantiate the characteristics of the degrees of severity of acute intestinal infection (AII) in elderly and senile patients with COVID-19.
Materials and methods. Conditionally pathogenic microorganisms were detected in the patients of the study group by the bacteriological method. The WHO age classification was used to estimate age. The presence of the definition of a coronavirus infection and comorbid conditions was ascertained based on the following methods: selection of indicators of the immunoenzymatic method, PCR test, measurements the degree of saturation of arterial blood with oxygen by pulse oximetry, heart rate, temperature marks, questionnaires NEWS and ABCD for monitoring the dynamics of the disease in patients. Dehydration scale (CDS) was used to determine the severity of acute intestinal infection.
The Charlson comorbidity index was used to characterize comorbid conditions. Statistical methods were used: the Kolmagorov-Smirnov test, the non-parametric Wald Wolfowitz test. The obtained results were performed using the Statistica 13 Trial program. The severity index of COVID-19 has been determined, with the help of which it is possible to identify and sort patients to identify complications and a quick algorithm for the doctor's actions and the conditions of the intensive care unit.
The results. Several indicators of the modified NEWS questionnaire were determined, which confirm that the age of patients ≥ 65 years is associated with a more severe course of the disease. It has been established that such comorbid conditions as: damage to peripheral vessels, dementia, the presence of peptic ulcer disease are associated with a milder course of GKI against the background of COVID-19. The incidence of diabetes without damage to the limbs is reliably associated with a more severe course of the disease. Analyzing the indicators of the ABCD system, namely: age of patients, laboratory and instrumental tests, pantry poor conditions, risk factors associated with the severity of the course of COVID-19 were assessed.
Conclusions. The total result of the Charlson comorbidity index was determined in patients with AII on the background of COVID-19. The results confirm that such patients have a higher probability and risk of mortality.
A direct moderate correlation has been proven between the total result of the NEWS questionnaire and the course of AII, which indicates a higher frequency of the formation of severe forms of the latter in the presence of higher values of the questionnaire and the corresponding more severe course of COVID-19. The results of the severity index of COVID-19 allow us to conclude that the data are associated with an increase in the severity of acute intestinal infection in elderly patients
Choir ensemble issues in the process of forming professional competences of the future teacher-musician
Authors: Sidorova Iryna 
Published: August 2022

The question of the special importance of a music teacher in the development of choral culture, which significantly affects the preservation of spiritual values ​​of the younger generation, is considered. The issue of choral ensemble in the process of formation of professional qualities of students of musical specialties of pedagogical educational institutions is covered. One of the professional competencies of a music teacher is the organization and management of vocal and choral activities. It is noted, that for a successful professional activity the teacher-choirmaster needs to understand the importance of the choral ensemble in working with choirs, be able to use different types of ensemble for quality choral sound. A special place in working with the choir is occupied by the feeling of the ensemble, the ability to adjust the choral sonority in accordance with the author's intention to reveal the artistic image.
The essence of the concept of «choral ensemble» is defined and the main types of it are characterized. It is specified, that the choral ensemble is the artistic unity of all components of choral sound and the merging in strength and timbre of individual voices in one choral part and the balance of sound between all parts of the choir. The importance of using such concepts as partial and general, natural and artificial ensemble in the training of future music teachers is revealed. Partial ensembles include ensembles of intonation, combat, timbre, dynamic, metrorhythmic, agogic, diction-orthoepic and tessitura. It is indicated what factors influence the choice of a particular type of ensemble. A number of regularities of the ensemble, which follow from the texture of the musical work, are highlighted. The use of different types of ensemble in practice is described on the examples of choral works. A detailed analysis of all types of choral ensemble is covered in the unaccompanied choral score by L. Shukailo «Oh, on Kupala» from the cantata «Seasons»
The usage of quick response codes: evolution and integration in classroom activities in the context of language learning
Authors: Leshchenko Tetyana , Zhovnir Maryna , Shevchenko Olena , Grinko Natalia 
Published: August 2022

The aim of this research is the exploration of the appearance, development, evolution of the Quick Response (QR-codes) and the feasibility of their using in the context of modern education. The authors of this article have shown that QR-codes can be interpreted as specific codes that are quickly readable by smartphones. QR-codes allow connection of real objects with any additional web content. Scanning QR-codes conveys a wide multitude of information, in particular educational materials. The paper emphasizes that оver the past years QR-codes have a wide range of uses across all types of industries and other spheres, specifically retail, marketing, advertising and logistics, etc. The authors have shown that the use of QR-codes in the field of education can be interesting and accessible in the context of the relevance of learning with the using of modern devices, and mobile learning. The research shows that the implementation of the modern technologies can contribute to the learning visible outcomes. The research presents the prerequisites and algorithm for the successful and methodically motivated use of QR-codes in education, especially language learning. It is noted, that QR-codes make it possible to combine educational material with additional web content, traditional learning environment with virtual. The attention is paid to technical means that provide access to encoded educational information. It is noted, that students must have special smartphones, cameras and a corresponding mobile application, downloaded to the phone for the successful using of QR-codes. The technical component contributes to the successful completing of assignments with QR-codes. In this context, applications that allow the combination of digital and physical information in real time through the use of mobile devices have special relevance. The technical characteristics of this tool in education can get extra motivation in students, since it involves a game in a natural format for them. In addition, the article presents the results of an experiment, conducted to clarify the purposes and areas of the use of QR-codes, applying them to access educational content
Development of methodological principles of routing in networks of special communication in the conditions of fire damage and radio electronic flow
Authors: Sova Oleg 
Published: August 2022

The object of research is a system of special communication. Decision making support systems (DMSS) are actively used in all spheres of human life. They are especially common in the processing of large data sets, forecasting processes, providing information support in the decision-making process by decision-makers. Systems of analysis of information transmission in special purpose radio communication systems are no exception. However, there are a number of problems in the transmission of information, namely: the transmission of information takes place in a complex electronic environment against the background of intentional and natural interference; elements of the radio communication system are the objects of primary fire damage due to high radio visibility for radio intelligence. The best solution in this situation is to integrate with the data of the information system analysis of the electronic environment, artificial neural networks and the ant algorithm. Their advantage is also the ability to work in real time and quickly adapt to specific situations. Therefore, in this paper the methodological principles of routing in special communication networks in the conditions of fire damage and electronic suppression are developed.
Improving the efficiency of information processing (reducing error) evaluation is achieved through the use of evolving neuro-fuzzy artificial neural networks; learning not only the synaptic weights of the artificial neural network, but also the type and parameters of the membership function. Efficiency of information processing is also achieved through training in the architecture of artificial neural networks; taking into account the type of uncertainty of the information to be assessed; synthesis of rational structure of fuzzy cognitive model. It reduces the computational complexity of decision-making; absence of accumulation of an error of training of artificial neural networks as a result of processing of the information arriving on an input of artificial neural networks. The approbation of the use of the offered technique on the example of the estimation of information transfer in the conditions of influence of destabilizing factors is carried out. This example showed an increase in the efficiency of evaluation at the level of 15–25 % on the efficiency of information processing.
Development of hardware and software support of computer-integrated technology of complex of secondary condensation of ammonia production
Authors: Babichenko Anatoliy , Lysachenko Ihor , Kravchenko Yana , Babichenko Juliya , Krasnikov Igor , Shutynskyi Oleksii 
Published: August 2022

The object of research is the technological complex of secondary condensation (TCSC) and the control system of a typical ammonia synthesis unit of the AM-1360 series.
The analysis of the conditions of its functioning and hardware and technological design was carried out. The coordinates of the control vector are determined. The features of the proposed functional diagram and the necessary algorithmic software for the computer-integrated control technology of the TCSC with a correction subsystem for decision-making under uncertainty are established. The implementation of the proposed solutions is complicated by the use of the information and control complex TDC-300 (USA) with closed-type software installed on the existing ammonia synthesis units. The need for such a control complex to implement a decision-making subsystem under conditions of uncertainty is shown to supplement the existing control system with hardware and software of an «open» type.
A computer-integrated TCSC technology based on a three-level hierarchical structure has been created. The implementation of the zero and first levels of such a structure form single software and hardware complex consisting of a programmable logic controller and an automated operator's workplace based on an industrial computer with installed software. A software implementation of decision-making on the correction of the coordinates of the control vector by additional hardware and software based on the VIPA logic controller and the Zenon SCADA system was made. A scheme of network information flows has been implemented, which illustrates the functioning of the decision-making correction subsystem in the general structure of the TCSC computer-integrated control technology.
Implementation of the developed system allows, under the existing uncertainties, to reduce the secondary condensation temperature by an average of 3 °C, which ensures an annual reduction in natural gas consumption by 1 million nm3. The proposed approach to the possibility of combining «open» and «closed» type hardware and software can be applied in other industries.
Development of a flexible antenna-wristband for wearable wrist-worn infocommunication devices of the LTE standard
Authors: Semenov Andriy , Semenova Olena , Pinaiev Bogdan , Kulias Roman , Shpylovyi Oleksandr 
Published: August 2022

The object of research is the process of radiation of electromagnetic waves from a flexible antenna-wristband. The subject of research is the wave parameters and directional properties of a flexible antenna-wristband. The existing problem is that it is necessary to ensure the electromagnetic compatibility of the radio frequency units of the wrist-worn infocommunication device. This problem is due to the fact that LTE/NB-IoT, Bluetooth/Wi-Fi, and GPS antennas must be placed inside the small-sized case of the infocommunication device. To solve this problem, let’s propose a simple and cheap version of a broadband flexible bracelet antenna for LTE networks, located outside the device case.
As a basis for the development of a flexible antenna-wristband, the authors chose a patch antenna, which is the base of the theory of microstrip antennas. This is due to the fact that the theoretical material is well developed for the calculation and study of the patch antenna. Structurally, a patch antenna consists of an upper metal layer that emits electromagnetic waves, a solid dielectric base, and a lower metal layer that acts as a reflector. With the classical approach to constructing a patch antenna, the width and length of its upper layer are commensurate, and its lower metal layer has geometric dimensions much larger than the upper metal layer. In contrast to the classical design, the authors proposed a new shape of the patch antenna, in which the length of the upper layer of the radiation surface is much greater than its width (5–6 times), and the lower metal layer has dimensions slightly larger than the dimensions of the upper layer.
The authors have developed a flexible antenna-wristband for the frequency range of 800–1300 MHz with a wave impedance of 50 ohms, 118.7×23 mm of the upper metal layer, and 124.7×25 mm of the lower metal layer. The length of the microstrip feed line of the antenna is 54.6 mm, its width is 2 mm, and the length of the insert is 51.6 mm. The flexible antenna-wristband is connected to the printed circuit board of the infocommunication device by soldering or using a mini-coaxial cable. The authors developed an experimental layout of a flexible antenna-wristband and studied its wave and directional properties. It has been established that in the frequency range 800–1300 MHz the voltage standing wave ratio coefficient of this antenna does not exceed 3.5. The flexible antenna-wristband has directional properties, which allows reducing the level of electromagnetic radiation in the direction of the human body.