bluuebunny/crossref_metadata_2025_split huggingface dataset:
D‐limonene nanoemulsion: lousicidal activity, stability, and effect on the cuticle of Columbicola columbae
Authors: Gadelhaq Sahar M. , Aboelhadid Shawky M. , Abdel‐Baki Abdel‐Azeem S. , Hassan Khaled M. , Arafa Waleed M. , Ibrahium Samar M. , Al‐Quraishy Saleh , Hassan Ahmed O. , Abd El‐Kareem Shams G. 
Published: August 2022

AbstractThe current study was conducted to investigate the efficacy and stability of D‐limonene (DL) and its nanoemulsion (DLN) against pigeon feather lice (Columbicola columbae) and their mode of action. DL pure form and DLN were prepared and characterized freshly and after storage for 50 days. In vitro bioassay on live lice was conducted with different concentrations of DL, DLN, and deltamethrin (DM). The results revealed significant mortality rates in the DL‐, DLN‐, DM‐treated groups when compared with the control (p < 0.05). The scanning electron micrographs of lice treated with DL and DLN revealed collapsed bodies with destruction in the cuticle of the mouthparts and damaged antennae. The 50 days stored DLN showed stability in their effectiveness when compared with the freshly prepared formulation. DL and DLN caused significant inhibition (p ≤ 0.05) in acetylcholinesterase activity (AchE). Malondialdehyde level (MDA) was significantly increased while glutathione was significantly decreased in DL‐ and DLN‐treated lice. In conclusion, DL and DLN have significant lousicidal activities. DLN showed better stability than DL after storage for 50 days. In addition, the mode of action of DL may associate with its effect on the cuticle of the lice body, inhibition of AchE, and increasing oxidative stress in the treated lice.
Control of resources in the nursing workplace: Power and patronage relations
Authors: Nepali Shobha , Einboden Rochelle , Rudge Trudy 
Published: August 2022

AbstractImmigrant nurses make up a large percentage of the Australian nursing workforce. Since the support in the workplace is expected to be inclusive for all nurses, the aim of this article is to explore how support and opportunities for professional growth, learning and development are distributed across different categories of nurses working in a neonatal intensive care unit (NICU). An ethnographic approach has opened an examination of the everyday workplace practices in the NICU to gain insight into how nurses made sense of the social and power relations occurring between themselves and their senior colleagues and how they experienced the support and opportunities they received in their workplace. As today's workplaces such as the NICU are diverse in races, culture and experiences, the concepts of intersectionality and cultural safety assisted in identifying inequality and injustice related to such diversity. The results showed how patronage relations rendered nurses with immigrant status with major disadvantage and left them clinically and culturally vulnerable. Such inequity defeats the reasons for encouraging skilled migration of nurses and poses questions on the cultural competency of recruiting organisations. Considering how cultural safety might guide staff development offers opportunities for authentic support to culturally diverse nurses.
MdTCP46 interacts with MdABI5 to negatively regulate ABA signalling and drought response in apple
Authors: Liu Ya‐Jing , An Jian‐Ping , Gao Ning , Wang Xun , Chen Xi‐Xia , Wang Xiao‐Fei , Zhang Shuai , You Chun‐Xiang 
Published: August 2022

AbstractTEOSINTE BRANCHED 1/CYCLOIDEA/PCF (TCP) transcription factors play crucial roles in plant abiotic stresses. However, little is known about the role of TCP genes in the drought stress tolerance of apple. Here, we found that abscisic acid (ABA) and drought treatment reduced the expression of MdTCP46, and overexpression of MdTCP46 reduced ABA sensitivity and drought stress resistance. MdTCP46 was found to interact with MdABI5 both in vitro and in vivo, and this interaction was essential for drought resistance via the ABA‐dependent pathway. Overexpression of MdABI5 enhanced ABA sensitivity and drought stress resistance by directly activating the expression of MdEM6 and MdRD29A. MdTCP46 significantly suppressed the transcriptional activity of MdABI5, thereby negatively regulating MdABI5‐mediated ABA signalling and drought response. Overall, our results demonstrate that the MdTCP46‐MdABI5‐MdEM6/MdRD29A regulatory module plays a key role in the modulation of ABA signalling and the drought stress response. These findings provide new insight into the role of MdTCP46 in ABA signalling and abiotic stress responses.
Comparative transcriptomics analysis reveals a calcineurin B‐like gene to positively regulate constitutive and acclimated freezing tolerance in potato
Authors: Chen Lin , Zhao Hongbo , Chen Ye , Jiang Fujing , Zhou Feiyan , Liu Qing , Fan Yongqi , Liu Tiantian , Tu Wei , Walther Dirk , Song Botao 
Published: August 2022

AbstractFreezing stress is a major limiting factor in crop production. To increase frost‐hardiness of crops via breeding, deciphering the genes conferring freezing‐tolerance is vital. Potato cultivars (Solanum tuberosum) are generally freezing‐sensitive, but some potato wild species are freezing‐tolerant, including Solanum commersonii, Solanum malmeanum and Solanum acaule. However, the underlying molecular mechanisms conferring the freezing‐tolerance to the wild species remain to be deciphered. In this study, five representative genotypes of the above‐mentioned species with distinct freezing‐tolerance were investigated. Comparative transcriptomics analysis showed that SaCBL1‐like (calcineurin B‐like protein) was upregulated substantially in all of the freezing‐tolerant genotypes. Transgenic overexpression and known‐down lines of SaCBL1‐like were examined. SaCBL1‐like was shown to confer freezing‐tolerance without significantly impacting main agricultural traits. A functional mechanism analysis showed that SaCBL1‐like increases the expression of the C‐repeat binding factor‐regulon as well as causes a prolonged higher expression of CBF1 after exposure to cold conditions. Furthermore, SaCBL1–like was found to only interact with SaCIPK3–1 (CBL‐interacting protein kinase) among all apparent cold‐responsive SaCIPKs. Our study identifies SaCBL1‐like to play a vital role in conferring freezing tolerance in potato, which may provide a basis for a targeted potato breeding for frost‐hardiness.
Extending the stereotype content model of racial attitudes among college freshmen
Authors: Jang Beksahn , Zeng Liwen 
Published: August 2022

AbstractObjectiveThis study draws on Fiske's stereotype content model (SCM) to understand the complexities and latent dimensions of racial outgroup attitudes in the United States.MethodsUsing the National Longitudinal Survey of Freshmen, we conduct a series of exploratory factor analyses to identify factorial structures of racial attitudes toward different ethnoracial groups and further establish the construct validity of identified dimensions by observing their association with a theoretically related concept, individualistic blame toward racial outgroups.ResultsWe identify a robust three‐factor solution that we label competence, warmth, and socioeconomic standing, the last of which is distinct from Fiske's SCM. We find that the dimensions of competence and socioeconomic standing are closely related to respondents’ individualistic attitudes toward their racial outgroups.ConclusionGiven the robustness and significance of the dimension of socioeconomic standing, we suggest employing our three dimensions to better conceptualize racial stereotypes.
Retrospective case series: Necrotising fasciitis in 23 dogs
Authors: Quilling Laura L. , Outerbridge Catherine A. , White Stephen D. , Affolter Verena K. 
Published: August 2022

AbstractBackgroundNecrotising fasciitis (NF) is a rare, rapidly progressive subcutaneous bacterial infection. Few studies have characterised NF in dogs.Hypothesis/objectivesTo retrospectively describe clinical and laboratory findings, with treatments and outcomes, in dogs with NF.AnimalsTwenty‐three client‐owned dogs treated at a veterinary teaching hospital between 1998 and 2021.Materials and MethodsMedical records and laboratory data from 23 dogs diagnosed with NF were reviewed.ResultsMale dogs were significantly over‐represented (p = 0.003). The most common presenting complaint was sudden lameness. Infection occurred in one or two limbs in 19 of 23 dogs, with right hindlimbs most often affected (13 of 23). Pitting oedema was evident in 14 of 23 dogs. Antibiotic and nonsteroidal anti‐inflammatory drugs were administered before presentation in nine and 13 of 23 dogs, respectively. Common clinicopathological abnormalities included hypoalbuminemia, hyponatremia, elevated liver enzymes, elevated creatine kinase, increased bands and lymphopenia. Streptococcus canis was isolated from 18 of 23 dogs. Histopathological features included acute necrosis and severe neutrophilic inflammation. Fifteen dogs were euthanised or died, while surgical intervention led to survival in eight of 23 dogs.Conclusions and clinical relevanceDogs presenting for acute swelling of a limb with oedema should have the diagnosis of NF considered and early surgical intervention might increase survival.
The Contribution of Innovation Hubs Towards Strengthening the Regional Development in Sweden
Authors: Chowdhury Ehsanul Huda , Fjellström Daniella , Osarenkhoe Aihie , Hannadige Sanvida Vishani Sawunda , Weerasinghe Dona Kithmini Chiranthini 
Published: August 2022

Aim: This study aims to explore the influence of innovation hubs (IHs) on innovation-based regional development. Methodology: This study applied a qualitative approach using a multiple case study method to collect data through 10 semi-structured interviews. A detailed analysis of the data collected was conducted using the content analysis method. Findings: The study shows that IHs can influence both economic and social development. An IH can attract knowledge and expertise as well as investors to the region through its activities and geographical location. The hubs support start-ups, entrepreneurs and smart specialization at the same time as they also enable sustainable development by creating social value. Regions can exchange resources through cross-collaboration via IHs. Research Implications: This study has important theoretical managerial and societal implications. It adds comprehensive knowledge to the existing theory on IHs and regional development by highlighting the influence of IHs on regional development. The study shows both economic and social influence in detail and points out a previously undiscussed concept in the context of the correlation between IHs and regional development.
Bioinformatically Expanded Next-Generation Sequencing Analysis Optimizes Identification of Therapeutically Relevant MET Copy Number Alterations in &gt;50,000 Tumors
Authors: Solomon James P. , Yang Soo-Ryum , Choudhury Noura J. , Ptashkin Ryan N. , Eslamdoost Nasrin , Falcon Christina J. , Martin Axel , Plodkowski Andrew , Wilhelm Clare , Shen Ronglai , Ladanyi Marc , Berger Michael , Zhang Yanming , Drilon Alexander , Arcila Maria E. 
Published: August 2022

Abstract

Purpose:
Clinical relevance thresholds and laboratory methods are poorly defined for MET amplification, a targetable biomarker across malignancies.

Experimental Design:
The utility of next-generation sequencing (NGS) in assessing MET copy number alterations was determined in &gt;50,000 solid tumors. Using fluorescence in situ hybridization as reference, we validated and optimized NGS analysis.

Results:
Incorporating read-depth and focality analyses achieved 91% concordance, 97% sensitivity, and 89% specificity. Tumor heterogeneity, neoplastic cell proportions, and genomic focality affected MET amplification assessment. NGS methodology showed superiority in capturing overall amplification status in heterogeneous tumors and defining amplification focality among other genomic alterations. MET copy gains and amplifications were found in 408 samples across 23 malignancies. Total MET copy number inversely correlated with amplified segment size. High-level/focal amplification was enriched in certain genomic subgroups and associated with targeted therapy response.

Conclusions:
Leveraging our integrated bioinformatic approach, targeted therapy benefit was observed across diverse MET amplification contexts.
To Rb or Not to Rb: Uncovering Unique Subsets of Small Cell Lung Carcinoma
Authors: Mahadevan Navin R. , Sholl Lynette M. 
Published: August 2022

SummaryThe use of IHC as a surrogate for specific underlying genomic alterations has allowed for increasingly comprehensive and accurate diagnosis of small cell lung carcinoma (SCLC). This is especially relevant in light of the increasing recognition of the biologic heterogeneity of this aggressive and difficult-to-treat lung tumor. Integrated genomic and IHC profiling of Rb status in SCLC yields new diagnostic insights and has translational implications.See related article by Febres-Aldana et al., p. 4702
Distinção e classe social no acesso ao ensino superior brasileiro
Authors: Moris Carlos Henrique Aparecido Alves , Casellato Fernando , Nascimento Matheus Monteiro , Agostini Gabriela , Massi Luciana 
Published: August 2022

Este artigo tem como objetivo estratificar e configurar as classes sociais e suas distinções no acesso ao ensino superior brasileiro. A pesquisa adota técnicas estatísticas para investigar essas relações por meio dos dados do Exame Nacional do Ensino Médio (Enem). Com base no capital cultural, econômico, social e linguístico, identificamos uma classe superior que tem acesso a todos os cursos; uma classe intermediária heterogênea, cuja fração privilegiada tem acesso a 35,8% dos cursos, mas não aos de prestígio; e uma classe inferior, cujo baixo desempenho permite acesso a menos de 5% dos cursos. Assim, o Enem opera como um elemento que reproduz a diferenciação e hierarquização, ao manter o ensino superior como uma distinção social.
Right-Wing Populism and Political Instrumentalization of Religion
Authors: Marchetti Rita , Righetti Nicola , Pagiotti Susanna , Stanziano Anna 
Published: August 2022

Abstract
The study investigates the online debate sparked by the political instrumentalization of religious symbols by right-wing populist leaders, taking as a case study the campaign communication of Matteo Salvini—leader of the Italian “Lega” party—in the run-up to the 2018 and 2019 general and European elections. Against the backdrop of theories on populism, religious publicization and politicization in a social media context, the research analyzes over 2,000 Facebook posts referring to Salvini and religion by using a mixed computational and qualitative method including semi-automated frame analysis and correspondence analysis. Results show that right-wing populism is capable of successfully appropriating religious symbols and setting the agenda for religious topics on social media, even challenging the authority of traditional religious authorities on their own ground. By attacking the Church, defending the religious sentiment of the people, and opposing Christian identity to Islam, religion is effectively integrated into the populist worldview.
Environmental Personhood as a Landscape Planning Tool
Authors: Buława Piotr , Buława Bartłomiej , Borsa Maciej 
Published: August 2022

Abstract
In the face of increasing human impact on the environment, it is necessary to look for new tools for sustainable landscape planning. One of them may be the institution of environmental personhood. The conducted studies based on an analysis of legal texts show that environmental personhood has evolved into a more complex institution. Increasing emphasis is placed on the intangible, cultural, and even spiritual aspects of granting legal personality to natural objects. The first implementations of environmental personhood in Ecuador, Bolivia, Australia, and India did not concern landscape, but the other cases in Colombia, New Zealand, and Canada did and have features typical of a landscape planning tool.
Classes nominales dans deux langues Niger-Congo : le baïnouck djifanghorois (atlantique) et le koalib (kordofanien)
Authors: Quint Nicolas 
Published: August 2022

Abstract
Koalib (Kordofanian, Central Sudan) and Djifanghor Nyun (Atlantic, Senegal) are two Niger-Congo languages, both of which exhibit rich noun class systems controlling various morphological concord patterns. In this paper, I will study in turn the main characteristics of each of these class systems by taking into account the following criteria: form of the class markers, agreement targets, interaction with number, semantics, class derivation, exceptions and integration of loanwords. I will then discuss the interest and significance of this comparison, bearing in mind the fact that the inclusion of both Nyun and Koalib into the Niger-Congo language family is largely due to the existence of these class systems.
The Netherlands, the EU and the Israeli-Palestinian Conflict
Authors: Malcontent Peter 
Published: August 2022

Abstract
This historical study assesses the determining factors behind the development of the Netherlands as one of Israel’s most faithful European allies in its conflict with the Palestinians. As such it wants to contribute to the academic debate on foreign policy Europeanisation that started two decades ago with the publication of Ben Tonra’s seminal study on The Europeanisation of National Foreign Policy. Comprehensive studies using primary sources of the EU’s individual member states’ policies towards the Israeli-Palestinian conflict continue to be scarce. This study about the Netherlands contributes to filling this gap. It first sets out why the Dutch government’s position has always been more pro-Israel compared to that of the EU by assessing the relative influences of the EU and the Netherlands’ national Parliament as external and internal foreign policy determinants. After having established the dominating role of Dutch Parliament the latter part of this article tries to explain what continues to motivate a right-wing majority in Dutch Parliament to protect the Dutch government’s traditional pro-Israel position against external influences from the European level.
Trends in the Management of Non-emergent Surgery for Diverticular Disease and the Impact of Practice Parameters
Authors: Ore Ana Sofia , Allar Benjamin G. , Fabrizio Anne , Cataldo Thomas E. , Messaris Evangelos 
Published: August 2022

Background Due to the rise in diverticular disease, the ASCRS developed practice parameters to ensure high-quality patient care. Our study aims to evaluate the impact of the 2014 practice parameters on the treatment of non-emergent left-sided diverticular disease. Methods This is a retrospective cohort study using the ACS-National Surgical Quality Improvement Project (ACS-NSQIP). Elective sigmoid resections performed by year were evaluated and compared before and after practice parameters were published. Results Overall, 46,950 patients met inclusion criteria. There was a significant decrease in the number of non-emergent operations when evaluating before and after guideline implementation ( P < .001). There was a significant decrease in the number of patients younger than 50 years of age operated electively for diverticular disease (25.8% vs. 23.9%, P = .005). Adoption of minimally invasive surgery continued to increase significantly throughout the study period. Conclusions Publication of the 2014 ASCRS practice parameters is associated with a change in management of diverticular disease in the non-emergent setting.
Total Pelvic Exenteration Combined With Sacral Resection for Rectal Cancer
Authors: Komori Koji , Tsukushi Satoshi , Yoshida Masahiro , Kinoshita Takashi , Sato Yusuke , Ouchi Akira , Ito Seiji , Abe Tetsuya , Misawa Kazunari , Ito Yuichi , Natsume Seiji , Higaki Eiji , Asano Tomonari , Okuno Masataka , Fujieda Hironori , Oki Satoshi , Aritake Tsukasa , Tawada Kakeru , Akaza Satoru , Saito Hisahumi , Narita Kiyoshi , Hiroki Kawabata , Yasui Kohei , Shimizu Yasuhiro 
Published: August 2022

Background This retrospective study aimed to demonstrate surgical operative approach of total pelvic exenteration combined with sacral resection with rectal cancer and elucidate the relationships between the level of sacral resection and short-term outcomes. Methods Twenty cases were selected. Data regarding sex, age, body mass index, neoadjuvant therapy, location of sacral resection (“Upper” or “Lower” relative to the level between the 3rd and 4th sacral segment), operative time, bleeding, and curability (R0/R1) were collected and compared to determine their association with complications exhibiting a Clavien-Dindo grade III. Results The complication rate was significantly higher for recurrent cancers (n = 10, 76.9%) than for primary cancers (n = 1, 14.3%) ( P = .007), and for “Upper” resection (n = 8, 72.7%) than for “Lower” resection (n = 3, 33.3%) ( P = .078). Significant differences were observed when complication rates for “Lower” and primary cancer resection (n = 3, .0%) were compared between “Upper” and recurrent cancers (n = 8, 100.0%) ( P = .007). Conclusion In patients with recurrent rectal cancer, “Upper” sacral resection during total pelvic exenteration is associated with a high complication rate, highlighting the need for careful monitoring.
Predictors of infrapopliteal vein bypass graft revision in patients with chronic limb-threatening ischemia
Authors: Kawai Yohei , Kodama Akio , Sato Tomohiro , Ikeda Shuta , Tsuruoka Takuya , Sugimoto Masayuki , Niimi Kiyoaki , Banno Hiroshi , Komori Kimihiro 
Published: August 2022

Purpose Surgical revascularization is the standard treatment for chronic limb-threatening ischemia (CLTI). However, some patients may require reintervention. The Global Anatomic Staging System (GLASS), which evaluates the complexity of infrainguinal lesions, was proposed. This study aimed to identify predictors for graft revision and evaluate whether GLASS impacts vein graft revision. Methods Between 2011 and 2018, CLTI patients who underwent de novo infrapopliteal bypass using autogenous veins were retrospectively analyzed. To assess anatomic complexity with GLASS, femoropopliteal, infrapopliteal, and inframalleolar/pedal (IM) disease grades were determined. The outcomes of patients with or without graft revision were compared. Cox regression analysis was performed. Results Thirty-six of the 80 patients underwent reintervention for graft revision. Compared to the non–graft revision group, the graft revision group exhibited significantly higher rates of GLASS stage III (66% vs 81%, p = 0.046) and grade P2 IM disease (25% vs 58%, p = 0.009). Multivariate analysis revealed that IM grade P2 (hazard ratio [HR], 3.35; 95% confidence interval [CI], 1.66–6.75; p = 0.001) and spliced vein grafts (HR, 3.18; 95% CI, 1.43–7.06; p = 0.005) were significantly associated with graft revision. Conclusions This study demonstrated that IM grade P2 and spliced vein grafts were predictors of graft revision. The GLASS stratification of IM disease grade may be useful in optimizing treatment for CLTI.