bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenobarbital is Associated with Cholestasis in Low Birth Weight Infants with Hemo-dynamically Significant Patent Ductus Arteriosus
Authors: Shen Xintian , Huang Yie , Peng Haibo , Zhou Ping , Hung-Chih Lin 
Published: August 2022

Abstract
Objectives
This retrospective study aimed to assess whether phenobarbital was associated with cholestasis in low birth weight (LBW) infants with hemo-dynamically significant patent ductus arteriosus (hsPDA).
Methods
This study included 148 LBW infants (24 ~ 34 weeks, birth weight < 2000 g) diagnosed with hsPDA, admitted to a level III neonatal intensive care unit (NICU) from September 2016 to September 2019. Of the 148 infants, twenty infants were diagnosed with cholestasis. To assess the independent association with cholestasis or direct bilirubin, binary logistic or multivariable linear regression was done, adjusting for major confounders (birth weight, gestational age, critical risk index for babies, invasive mechanical ventilation, any sepsis onset in 28 days and etc).
Result
Binary logistic regression analysis was done adjusting for 12 related confounders. The “delay of full enteral feeding” was still associated with “duration of phenobarbital” (DOP) (OR: 1.571; P = 0.015) or “duration of phenobarbital before cholestasis onset” (DOPBCO) (OR: 1.662; P = 0.014). Cholestasis was still associated with “DOP” (OR: 1.553; P = 0.005) or “DOPBCO” (OR: 1.353; P = 0.088). “High direct bilirubin peak” (> 1.5 mg/dl) was still associated with “DOP” (OR: 1.686; P = 0.003) or “DOPBCO” (OR: 1.511; P = 0.021). Multivariate linear regression revealed that “persist time of cholestasis” was associated with “DOB” (B: 2.254; P = 0.050) after adjustment of “delay of full enteral feeding”.
Conclusion
This study found that phenobarbital was associated with neonatal cholestasis in LBW infants with hsPDA. Phenobarbital should be used cautiously in this population.
[68Ga]Ga-Prostate-specific membrane antigen PET/CT in ovarian tumours: potential to differentiate benign and malignant tumours before surgery. A preliminary report
Authors: Kunikowska Jolanta , Bizoń Magdalena , Pełka Kacper , Derlatka Paweł , Olszewski Maciej , Królicki Leszek 
Published: August 2022

Abstract
Purpose Ovarian cancer is usually diagnosed in an advanced stage of disease due to the absence of specific symptoms and a lack of sensitive diagnostic methods. Prostate-specific membrane antigen (PSMA) is expressed on prostate cancer cells, but can be found in other tumours such as ovarian cancer. The aim of this pilot study was to evaluate the feasibility of using [68Ga]Ga-PSMA-11 PET/CT in detection of ovarian neoplasm before surgical treatment.Material and methods: Eight women with mean age of 56.0±16.2 years were included in the study. All patients underwent transvaginal ultrasound followed by CT scan of the chest and abdomen as qualification for surgery. Within a 1-week interval, PET/CT was performed on a Siemens Biograph scanner, 60 min after injection of 2 MBq/kg [68Ga]Ga-PSMA-11.Results: In three cases (37.5%) the [68Ga]Ga-PSMA-11 PET/CT was positive, whereas histological examination confirmed two serous ovarian cancer cases and one ovarian borderline tumour. The SUVmax in the serous ovarian cancer was 8.7 and 4.1, and in the borderline ovarian tumour it was 13.8. No correlation was found between antigen CA 125 level and [68Ga]Ga-PSMA expression. Range of tumour SUVmax was not correlated with stage of disease. The remaining 62.5% (5/8) were negative in [68Ga]Ga-PSMA-11 PET/CT and histopathology confirmed benign pelvic tumour.Conclusion The initial experience supports the potential to use [68Ga]Ga-PSMA-11 in ovarian cancer to differentiate malignant and benign tumours before surgery. This study was approved by the Ethical Committee of the Medical University of Warsaw (KB/2/A/2018).
Fuzzy based Secured OTMRP Protocol for Video Transmission in Wireless Mesh Networks
Authors: Loret shajilin , Kumar T. Ganesh 
Published: August 2022

Abstract
In multimedia wireless networks Wireless mesh networks (WMNs) have emerged as a key technology to meet the challenges. Mostly the WMN are multi-hop in nature and the routing protocols must be robust against both dynamically changing topology and malevolent attacks for achieving availability. In WMN, Security is one of the primary concerns and several secure routing protocols have been proposed to address the security vulnerabilities but still there exist problems. In order to overcome this, an Optimal Trusted Multipath Routing Protocol (OTMRP) using Fuzzy is proposed which improves the security in path selection by integrating both direct as well as indirect trust in WMNs. The Simulation results show that OTMRP outperforms well than other similar trust models by considering the various parameters such as Average throughput, Packet Delivery Ratio, Energy consumption, and Trust value computation.
Association between the uric acid to high density lipoprotein cholesterol ratio and alanine transaminase in Chinese short stature children and adolescents: a cross-sectional study
Authors: Li Guangxin , Zhao Qianqian , Zhang Xinran , Ban Bo , Zhang Mei 
Published: August 2022

Abstract
Objective
This research aimed to investigate the relationship between the uric acid to high-density lipoprotein cholesterol ratio (UHR) and alanine aminotransferase (ALT) in children and adolescents with short stature.
Methods
In this cross-sectional analysis, the clinical data of 1510 children with height below − 2 SD who were evaluated at the Department of Endocrinology, Affiliated Hospital of Jining Medical University from March 1, 2013, to December 31, 2021, were selected. Anthropometric and biochemical indicators were measured.The relationship between UHR and ALT was analysed.
Results
The univariate analysis results showed that UHR was positively associated with ALT (β 0.43, P < 0.0001). Furthermore, after adjusting for possible confounding factors,a nonlinear relationship was detected between UHR and ALT through smooth curve fitting, and the inflection point of UHR was 10.93% after multivariate piecewise linear regression analysis. ALT increased with UHR elevation when the UHR was greater than 10.93% (β 0.69, 95% CI 0.39, 0.98; P < 0.0001). However, we did not observe a significant relationship when the UHR was less than 10.93% (P = 0.9229).
Conclusion
Our study demonstrated that in Chinese children and adolescents with short stature, UHR may be associated with the regulation of ALT levels, and this relationship merits further investigation.
Prediction of distant metastasis in esophageal cancer using a radiomics-clinical model
Authors: Zhu Chao , Mu Fengchun , Wang Songping , Qiu Qingtao , Wang Shuai , Wang Linlin 
Published: August 2022

Abstract
Background
Distant metastasis, which occurs at a rate of 25% in patients with esophageal cancer (EC), has a poor prognosis, with previous studies reporting an overall survival of only 3–10 months. However, few studies have been conducted to predict distant metastasis in EC, owing to a dearth of reliable biomarkers. The purpose of this study was to develop and validate an accurate model for predicting distant metastasis in patients with EC.
Methods
A total of 299 EC patients were enrolled and randomly assigned to a training cohort (n = 207) and a validation cohort (n = 92). Logistic univariate and multivariate regression analyses were used to identify clinical independent predictors and create a clinical nomogram. Radiomic features were extracted from contrast-enhanced computed tomography (CT) images taken prior to treatment, and least absolute shrinkage and selection operator (Lasso) regression was used to screen the associated features, which were then used to develop a radiomic signature. Based on the screened features, four machine learning algorithms were used to build radiomics models. The joint nomogram with radiomic signature and clinically independent risk factors was developed using the logical regression algorithm. All models were validated and compared by discrimination, calibration, reclassification, and clinical benefit.
Results
Multivariable analyses revealed that age, N stage, and degree of pathological differentiation were independent predictors of distant metastasis, and a clinical nomogram incorporating these factors was established. A radiomic signature was developped by a set of sixteen features chosen from 851 radiomic features. The joint nomogram incorporating clinical factors and radiomic signature performed better [AUC(95% CI): 0.827(0.742–0.912)] than the clinical nomogram [AUC(95% CI): 0.731(0.626–0.836)] and radiomics predictive models [AUC(95% CI): 0.754(0.652–0.855), LR algorithms]. Caliberation and decision curve analyses revealed that the radiomics-clinical nomogram outperformed the other models. In comparison to the clinical nomogram, the joint nomogram's NRI was 0.114 (95% CI: 0.075–0.345), and its IDI was 0.071 (95% CI: 0.030–0.112), P = 0.001.
Conclusion
We developed and validated the first radiomics-clinical nomogram for distant metastasis in EC which may aid clinicians in identifying patients at high risk of distant metastasis.
Expression of Candidate Marker Genes of Sugar Starvation is Enhanced in Growth-Suppressed Parthenocarpic Cucumber Fruit
Authors: Tazuke Akio , Murakami Kaori , Kinoshita Tsuguki , Asayama Munehiko , Kuboyama Tsutomu 
Published: August 2022

Abstract
Background
In plant, sugar starvation occurs in many stress conditions. Although the involvement plant hormones is known, the underlying mechanism of fruit parthenocarpy is not known. Investigation of sugar starvation in growth suppressed parthenocarpic fruit may shed light on the parthenocarpy mechanism.
Method
Cucumber (Cucumis sativus L.) fruits were followed and harvested at 0, 2, 4, 6, 8 days after anthesis, and the expression of eight candidate marker genes of sugar starvation and sugar concentration were examined.
Results
A growth analysis of fruits showed variability in the onset of exponential growth. Fruits in which growth was suppressed for more than 8 days after anthesis tended to abort. The variation in transcript levels was very high. The correlation matrix of the transcript level of the genes and the time course of the expression of the eight genes led to their classification into three groups. This varying pattern of gene expression may reflect the dynamics of parthenocarpic fruit. Moreover, the gene expression patterns and hexose concentration suggested that sugar starvation occurs in parthenocarpic fruit in which growth is suppressed. Therefore, the asparagine synthetase gene and the Cucumis sativus Somatic Embryogenesis Zinc Finger 1 (CsSEF1), Cucumis sativus Fruit Defoliation Induced 1 (CsFDI1), CsaV3_1G000860, CsaV3_3G041280, and CsaV3_3G023510 genes were regarded as good marker genes of sugar starvation.
Conclusion
The occurrence of sugar starvation suggests the low sink activity precedes the decline in fruit growth. This suggests the sink activity is the control point of parthenocarpic fruit set.
Hyperbaric Oxygen Therapy for Long COVID (HOT-LoCO), an interim safety report from a randomised controlled trial
Authors: Kjellberg Anders , Hassler Adrian , Boström Emil , Gharbi Sara El , Al-Ezerjawi Sarah , Kowalski Jan , Rodriguez-Wallberg Kenny A , Bruchfeld Judith , Ståhlberg Marcus , Nygren-Bonnier Malin , Runold Michael , Lindholm Peter 
Published: August 2022

Abstract
BackgroundWith ˜50 million individuals suffering from post-COVID condition (PCC), low health related quality of life (HRQoL) is a vast problem. Common symptoms of PCC, that persists 3 months from the onset of COVID-19 are fatigue, shortness of breath and cognitive dysfunction. No effective treatment options exist. Hyperbaric oxygen (HBO2) is a candidate drug. ObjectivesThis interim analysis describes our cohort and evaluates the safety of HBO2.MethodsIn an ongoing randomised, placebo-controlled, double blind, clinical trial, 20 previously healthy subjects with PCC were assigned to HBO2 or placebo. Primary endpoints are physical domains in RAND-36; Physical functioning (PF) and Role Physical (RP) at 13 weeks. Secondary endpoints include objective physical tests. Safety endpoints are occurrence, frequency, and seriousness of Adverse Events (AEs). An independent data safety monitoring board (DSMB) reviewed unblinded data. The trial complies with Good Clinical Practice. Safety endpoints are evaluated descriptively. Comparisons against norm data was done using t-test.Results20 subjects were randomised, they had very low HRQoL compared to norm data. Mean(SD) PF 31.75(19.55) (95% Confidence interval; 22.60-40.90) vs 83.5(23.9) p<0.001 in Rand-36 PF and mean 0.00 (0.00) in RP. Very low physical performance compared to norm data. 6MWT 442(180) (95% CI; 358-525) vs 662(18) meters p<0.001.31 AEs occurred in 60% of subjects. In 20 AEs, there were at least a possible relationship with the study drug, most commonly cough and chest pain/discomfort.ConclusionsAn (unexpectedly) high frequency of AEs was observed but the DSMB assessed HBO2 to have a favourable safety profile. Our data may help other researchers in designing trials. Trial Registration ClinicalTrials.gov: NCT04842448. Registered 13 April 2021, https://clinicaltrials.gov/ct2/show/NCT04842448
Evaluation of nausea and vomiting in the first trimester on the risk of adverse birth outcomes and the contribution of genetic polymorphisms: a pilot prospective study
Authors: Li Nana , Xue Zhiwei , Xu Hongmei , Yang Ping , Wang Ke , Li Lu , Kang Hong , Wang Meixian , Deng Ying , Li Xiaohong , Wang Yanping , Zhu Jun , Yu Ping , Zhou Shu 
Published: August 2022

Abstract
Purpose
To evaluate the impact of Nausea and vomiting in pregnancy (NVP) on the risk of preterm birth (PTB) and low birth weight (LBW), and explore the effect of genetic polymorphisms on the severity of NVP.
Methods
A prospective study was conducted. Participants’ experience of NVP prior to 12 gestational weeks were evaluated by a Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) scale. 11 Single Nucleotide Polymorphisms (SNPs) loci located in growth differentiation factor 15 (GDF15) and leucine rich repeat containing 25 (LRRC25) gene of chr19p13.11 and intergenic region of chr4q12 were genotyped, which were implicated as genetic risk factors for NVP. Logistic regression models were applied to determine the effect of NVP in the first trimester on the risk of PTB and LBW, and genetic polymorphisms on the risk of NVP.
Results
Among 413 pregnant women, the incidence of nausea and vomiting was 85.5% (n = 353) in the first trimester, including 38.7% (n = 160) mild vomiting, 42.6% (n = 176) moderate vomiting and 4.1% (n = 17) severe vomiting. 33 were PTB, 20 were LBW. Compared with pregnant women without NVP, women with mild, moderate or severe NVP in the first trimester were not associated with the risk of PTB and LBW. Besides, the polymorphisms of 11 SNPs loci were not associated with the risk of NVP.
Conclusions
Our study indicated that symptoms of nausea and vomiting in the first trimester were not significantly associated with PTB and LBW, and there were also no associations between GDF15 and LRRC25 polymorphisms and NVP.
Multi-country evaluation of the durability of pyrethroid plus piperonyl-butoxide insecticide-treated nets: study protocol
Authors: Mbuba Emmanuel , Odufuwa Olukayode G. , Moore Jason , Mmbaga Selemani , Tchicaya Emile , Edi Constant , Chalageri Vani , Uragayala Sreehari , Sharma Amit , Rahi Manju , Raghavendra Kamaraju , Eapen Alex , Koenker Hannah , Ross Amanda , Moore Sarah J. 
Published: August 2022

Abstract
Background
Mass distributions of long-lasting insecticidal nets (LLINs) has contributed to large reductions in the malaria burden. However, this success is in jeopardy due in part to the increasing pyrethroid-resistant mosquito population as well as low LLINs coverage in various areas because the lifespan of LLINs is often shorter than the interval between replenishment campaigns. New insecticide-treated nets (ITNs) containing pyrethroid and piperonyl-butoxide (PBO) have shown a greater reduction in the incidence of malaria than pyrethroid LLINs in areas with pyrethroid-resistant mosquitoes. However, the durability of pyrethroid-PBO ITNs under operational settings is not fully characterized. This study will measure the bioefficacy and physical durability of pyrethroid-PBO ITNs over three years to assess whether they meet the World Health Organisation (WHO) three years operational performance criteria required to be categorised as “long-lasting”.
Methods
A prospective household randomized controlled trial will be conducted simultaneously in Tanzania, India and Côte d’Ivoire to estimate the field durability of three pyrethroid-PBO ITNs (Veeralin®, Tsara® Boost, and Olyset® Plus) compared to a pyrethroid LLIN: MAGNet®. Durability monitoring will be conducted up to 36 months post-distribution and median survival in months will be calculated. The proportion of ITNs lost (attrition), the physical integrity of the nets, resistance to damage score, the proportion of ITNs meeting WHO bioefficacy criteria against laboratory-reared resistant and susceptible mosquitoes, and insecticidal persistence over time will be estimated. The non-inferiority of Veeralin® and Tsara® Boost to the first-in-class, Olyset® Plus will be assessed for mortality, and the equivalence of 20 times washed ITNs compared to field aged ITNs will be assessed for mortality and blood-feeding inhibition endpoints in the Ifakara Ambient Chamber Test, Tanzania.
Discussion
This will be the first large-scale prospective household randomised controlled trial of pyrethroid-PBO ITNs in three different countries representing East Africa, West Africa and South Asia region simultaneously. The study findings will generate information on average replenishment intervals for PBO nets.
Innate immunity gene Nod2 protects mice from orthotopic breast cancer
Authors: Gurses Serdar , Dziarski Alisha , Gupta Dipika 
Published: August 2022

Abstract
Nod2 is involved in innate immunity to bacteria, regulation of metabolism, and sensitivity to cancer. Nod2 polymorphism is associated with breast cancer, but the role of Nod2 in the development and progression of breast cancer is unknown. Here, we tested the hypothesis that Nod2 protects mice from breast cancer using the 4T1 orthotopic model of mammary tumorigenesis. We demonstrate that Nod2−/− mice have higher incidence and larger tumors than WT mice. Detailed analysis of the tumor transcriptome showed that Nod2−/− mice had increased expression of genes that promote DNA replication and cell division and decreased expression of genes required for lipolysis, lipogenesis, and steroid biosynthesis compared with WT mice. Nod2−/− mice also had lower expression of genes required for adipogenesis and higher delipidation than WT mice. The tumors in Nod2−/− mice had decreased expression of genes associated with PPARα/γ signaling, increased activation of STAT3, decreased activation of STAT5, and no change in the activation of ERK compared with WT mice. Thus, we demonstrate that Nod2 protects mice from the 4T1 orthotopic breast tumor, and that tumors in Nod2−/− mice have higher DNA replication, cell cycling and delipidation than WT mice.
Research on Fault Diagnosis of ZPW-2000R Track Circuit Based on OC-SVM and DNN
Authors: xie benkai , cai shuiyong , huang chunlei , yu jianli , chen guangzhi 
Published: August 2022

Abstract
Aiming at the problem that there are many types of faults in the current track circuit and it is difficult to obtain high-quality fault label data, this paper proposes a fault diagnosis method for ZPW-2000R track circuit based on OC-SVM and DNN. In this method, OC-SVM is first used to classify and identify 48 monitoring data collected by ZPW-2000R track circuit to collect signal data of different fault types; then the DNN method is used to train the collected fault data to automatically classify the known fault data. A large number of experiments were carried out on this method using the data of ZPW-2000R track circuit, the diagnostic experimental results show that the proposed fault diagnosis method can effectively automatically collect the novel fault data and accurately detect the fault type, and the accuracy of fault diagnosis can reach more than 98%.
The role of temperature in reproductivity trade-offs and life span in a winter-adaptive arthropod
Authors: Feng Lichao , Du Zhiqi , Chen Ting-Wen , Wu Donghui , Zhang Bing 
Published: August 2022

AbstractTemperature plays a key role in the development and population maintenance of arthropods, especially for those living in cold environments. In the temperate zone, one of the most common soil-dwelling arthropods is Collembola. Instead of tracking warm and thermal temperature ranges, some Collembola species are psychrotrophic, i.e., they are well-adapted to lower temperatures. We investigatedDesoria ruseki(Isotomidae), a Collembola species widely distributed in high latitudes in the Palearctic and adapted to winter, to determine the crucial temperature conditions for the sustainability of field populations of this winter-adaptive arthropod. We incubated the adult individuals of the species at six temperatures ranging from -5°C to 30°C for 98 days. We found that 0°C and 5°C, corresponding to the temperatures when the species is active in the field between late autumn (November) and early spring (April), were the best temperatures for the survival of the lab individuals. However, they died out quickly at temperatures above 20°C without laying eggs. In contrast, the species could lay eggs between 0℃ and 15℃: the higher the temperature was, the earlier they laid eggs. In addition, longer periods were needed for juveniles to hatch from eggs at lower temperatures. Our study indicates that, rather than colder conditions, hotter environments are likely to be more detrimental to the winter-adaptive Collembola species, thereby suggesting major threats to biodiversity at high latitudes under the current global warming regimes.