bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metodología para la construcción del estado del arte del sector turístico: Validación en el sur del Huila.
Authors: Vinasco Guzmán Martha Cecilia 
Published: May 2022

El presente artículo expone la propuesta metodológicade un estado del arte para facilitar el análisis de los documentos referentes al turismo. El objetivo es el de proponer y validar una metodología que permita recopilar, caracterizar, sistematizar y analizar el estado del conocimiento actual de los documentos relacionados con el turismoy validarlo con los documentos emitidos por las instituciones dedicadas a promocionar el turismo sostenible en los municipios de Pitalito, San Agustín e Isnos. Se construyó un esquema categorial en torno a esferas referidas a actores involucrados (institucional - estatal – local, privada – colectiva); ámbitos: político-sustentable, competitivo-productivo e investigativo-social; categorías para análisis y síntesis y subcategorías como una clasificación adicional. En los hallazgos, dada la reiteración de los mismos aspectos, indica una baja capacidad de ejecución de las estrategias por parte de gobiernos nacionales, departamentales y locales, en especial en la zona sur del Huila. La metodología permite realizar una investigación sistemática en torno a los documentos turísticos a través del tiempo, para determinar las necesidades de información y para posibilitar la toma de decisiones que se traduzcan en mejoras en la prestación de los servicios turísticos.
Obstetric outcome of pregnancies with borderline versus normal amniotic fluid index at term: an analytical cross sectional study
Authors: Bhangale Siddhika , Kose Varsha 
Published: May 2022

Background:Amniotic fluid plays a vital role in the normal growth of fetus and promotes normal musculoskeletal development. Amniotic fluid index (AFI) is preferred method of amniotic fluid measurement in pregnancy which is done by ultrasonography. The normal range of AFI is between 5-24 cm. Any value above 24 cm is considered hydramnios and below 5 cm as oligohydramnios. More accepted range for borderline amniotic fluid index is 5-8 cm. The objective of this analytical cross-sectional, study was carried out to characterize maternal and fetal risks associated with borderline AFI in pregnancies, compared with normal amniotic fluid index.Methods:This study included 180 women fulfilling inclusion criteria. 90 women were in borderline AFI group and 90 women in normal AFI group. Both were compared based on maternal outcome such as mode of delivery- normal vaginal delivery, instrumental, LSCS. Indication of instrumental, caesarean section and associated maternal morbidity, perinatal morbidity and mortality was compared.Results:Out of 90 women, 41 women delivered vaginally (45.55%), 30 by instrumental (33.33%) and 19 by LSCS (21.11%). 26 NICU admission in borderline AFI group 13 were due to neonatal jaundice, 5 were due to respiratory distress, 3 due to sepsis, 2 due to seizures, 1 had necrotizing enterocolitis, 1 was due to persistent tachypnea, 1 due to severe hypoglycemia. In borderline AFI group 3.3% perinatal mortality was reported.Conclusions:Maternal morbidity, perinatal morbidity and mortality was higher in borderline AFI group as compared to normal AFI group. There is a significant association of amniotic fluid volume with the maternal morbidity, perinatal morbidity and perinatal mortality.
A comparative study of the transfusion effect of single donor apheresis platelets versus random donor platelets in the management of severe dengue infection in children
Authors: B. S. K. Buddharaju Chandra Deve Varma , Chandrakanth Gujjarlamudi , Shiva Reddy Konala Venkata , Reddy Vundela Lokeswara , Som Lambadi Shanmukha 
Published: May 2022

Background: The national vector-borne diseases control programme (NVBDCP) dengue clinical care guidelines 2014 clearly specify the indications for platelet transfusion in dengue fever. The goal of the study was to see how successful guideline-driven platelet transfusion was, as well as whether single donor platelet (SDP) transfusion was superior to random donor platelet transfusion (RDP), which was widely thought but unproven.Methods: Two ml of the patient's blood were collected in EDTA tubes at two distinct times: once before the transfusion and the other 24 hours afterwards and the data were assessed using corrected count increments (CCI), percentage recovery (PR) and other criteria.Results: Platelet increments were substantially larger with SDP transfusions at 24 hours than with RDP transfusions (p<0.01 for 24 hours post-transfusion period). However, in both groups, the corrected count increment and percentage recovery were nearly identical and the difference was statistically insignificant.Conclusions: Although post-transfusion increments were considerably higher in SDP patients than in RDP patients, the CCI and PR were similar in both groups of patients. When it comes to the number of donors exposed to patient and leukoreduction, SDP is superior to RDP in terms of logistics. However, in developing countries, SDP may be advised only in selected patients based on accessibility and affordability, due to their high cost and higher technical competence required.
Prevalence and risk factors of sensorineural hearing loss in patients with systemic hypertension
Authors: Mohan Avinash , Renjit Rejee Ebenezer , Manonmony Sajilal 
Published: May 2022

<p><strong>Background: </strong>Hearing loss severely affects the quality of life. At the same time there is a high burden of systemic hypertensives in the community. Various authors have conflicting opinions regarding the association of hearing loss with systemic hypertension. Our study was conducted in this context to find the prevalence and risk factors associated with sensorineural hearing loss in patients with systemic hypertension.</p><p><strong>Methods: </strong>This is a hospital based cross-sectional study conducted at Dr. Somervell memorial CSI Medical College, Karakonam, during the period December 2015 to October 2017. A sample of 140 hypertensives were studied. They were subjected to pure tone audiometry after detailed history and physical examination including recording of blood pressure.</p><p><strong>Results: </strong>Out of the 140 hypertensives, 61 patients (43.6%) were detected to have sensorineural hearing loss. In our study, age, stage of systemic hypertension and duration of systemic hypertension were the risk factors found to be associated with sensorineural hearing loss.</p><p><strong>Conclusions: </strong>Sensorineural hearing loss has a high prevalence among patients with systemic hypertension. Hence, a pure tone audiometry should be done routinely in all hypertensives, particularly in elderly patients with long standing systemic hypertension. Periodic audiological assessment should be incorporated in them to start rehabilitation as early as possible. Early diagnosis of systemic hypertension in the community and initiation of treatment can help to further hinder the progression of microvascular disease that leads to target organ damage.</p>
Evaluation of audiological profile and graft uptake by endoscopic composite cartilage graft tympanoplasty in chronic otitis media patients
Authors: Bisht Akanksha , Pandey Apoorva Kumar , Haq Ajazul , Varma Arvind 
Published: May 2022

<p class="abstract"><strong>Background:</strong> Transcanal endoscopic ear surgery (TEES) permits wide-angle vision, high resolution, and magnification as well as the direct visualization of hidden areas of the middle ear cavity. The aim of the study was to determine the anatomic and functional results of endoscopic composite cartilage tympanoplasty in chronic otitis media cases with safe central perforation.</p><p class="abstract"><strong>Methods:</strong> This prospective study was conducted on 50 chronic otitis media cases with safe central perforation (small/medium) between February 2020 to July 2021 in a tertiary care center. All the patients were selected as per the described inclusion and exclusion criteria. All cases underwent endoscopic composite cartilage graft tympanoplasty (type-I) under general anesthesia. Audiological outcomes were assessed by comparing mean pure tone average pre-and post-operatively and morphological results (successful graft uptake) were evaluated at 6 months. </p><p class="abstract"><strong>Results:</strong> The result of this study showed that out of 50 cases 47 had successful graft uptake (94%) while 3 cases were found to have a residual perforation. The pre-operative air conduction threshold (ACT) was 42.82±7.33 dB whereas postoperative ACT was 31.26±7.48 dB, and the difference between the preoperative and postoperative values was found to be statistically significant. </p><p class="abstract"><strong>Conclusions:</strong> This study concluded that endoscopic composite cartilage tympanoplasty in chronic otitis media cases with dry central perforations is an effective surgical modality with good audiological and morphological outcomes and negligible post-operative complications.</p>
A huge high rising cervico-facial lymphangioma in an adolescent male: from pterygoid to hyoid
Authors: Chakravarty Sharmistha , Nagarkar Nitin M. , B. Nidhin S. , P. Abhishek A. 
Published: May 2022

<p class="abstract">Cervicofacial lymphangioma is a benign swelling of the neck and is commonly seen in paediatric population. Common sites of involvement are the submandibular space and the posterior triangle and rarely involves the face. We present a rare case of a huge cervico-facial lymphangioma in a 14 year old male where the swelling presented one year back and had progressively increased in size extending from the medial pterygoids and pterygomandibular space above to myelohyoid muscle below. Intraoperatively, it was closely abutting the submandibular gland mimicking salivary gland retention cyst and the facial artery was traversing through the mass. Complete surgical excision of the mass was performed along with removal of the ipsilateral submandibular gland. Salivary gland mucocele and cervicofacial lymphangioma were the two main differential diagnosis in our case. Intraoperative findings of macrocystic spaces with septations pointed towards a lymphangioma. Post operative histopathology confirmed it to be lymphangioma lined with endothelial cells. We concluded from this case that cervicofacial swellings in higher age groups should have lymphangiomas as differential diagnosis. As the swelling ascended up to the skull base, careful radiological assessment, meticulous surgical plan and cranio-caudal exposure from the zygomatic arch above to the hyoid below helped in complete surgical excision of the mass. </p>
An increase in mean platelet volume (MPV) as a predictor of mortality in children with sepsis
Authors: Lestari Rianti Puji , Sumadiono Sumadiono , Arguni Eggi 
Published: May 2022

Sepsis is associated with increased morbidity and mortality in children worldwide, mainly in developing countries. This fatal risk emphasizes the importance of finding accessible and inexpensive parameters to be used as predictors for mortality in children with sepsis. The aim of this study was to determine the role of increased mean platelet volume (MPV) as a predictor for mortality in children with sepsis. A case control study was applied using medical records of all in-patients aged 1 mo -18 y diagnosed with sepsis at Dr. Sardjito General Hospital, Yogyakarta from January 2015-December 2016. Bivariate and multivariate analyses by Chi-square and logistic regression to evaluate the correlations between increased MPV within the first 24-72 h (ΔMPV>0) and mortality were applied. Eighty-one eligible subjects met the inclusion/exclusion criteria with the mortality was 52%. Chi-square analysis showed significant correlations between increased MPV and mortality (p=0.005). Multivariate analysis showed increased MPV within the first 24-72 h after sepsis diagnosis as a predictor for mortality after controlling for sex and AKI (adjusted OR 3.851; 95% CI:1.354-10.948; p= 0.011). In conclusion, an increase in MPV within the first 24-72 h after diagnosed is an independent predictor for mortality in children with sepsis.
Speech Acts Analysis of The Main Characters on Amy Tan's "The Joy Luck Club"
Authors: Mariani Nanik , Rini Sulistyo , Satrio Adrie 
Published: May 2022

Abstract: This study tries to describe how speech acts are applied through the main character in The Joy Luck Club. It is broken down into: (l) a description of the types of illocutionary speech acts performed, (2) a description of how the speech acts are carried out which is also translated into two sub-objectives, namely: (I) a description of how the illocutionary acts are performed; and (2) a description of how the perlocutionary act was carried out. The description of the types of illocutionary acts is based on Searle's category of illocutionary acts which is also used as a category for the actual meaning of an utterance. While the forms are based on the syntactic form of the sentence. While the perlocutionary act is said to be effective if the speech act has an influence on the thoughts, actions, or feelings of the listener in accordance with what was intended by the speaker. To answer these research questions, a qualitative research design was carried out. Data was collected from the language use of the main characters in Amy Tan's novel, The Joy Luck Club. Then, dialogues, monologues, and actions were collected, breed Sctibed, and analyzed. The results showed that the type and highest meaning used by the main character was representative. Meanwhile, in terms of form, most use declarative. Moreover, the perlocutionary acts produced are mostly ineffective. Abstract: This study tries to describe how speech acts are applied through the main character in The Joy Luck Club. It is broken down into: (l) a description of the types of illocutionary speech acts performed, (2) a description of how the speech acts are carried out which is also translated into two sub-objectives, namely: (I) a description of how the illocutionary acts are performed; and (2) a description of how the perlocutionary act was carried out. The description of the types of illocutionary acts is based on Searle's category of illocutionary acts which is also used as a category for the actual meaning of an utterance. While the forms are based on the syntactic form of the sentence. While the perlocutionary act is said to be effective if the speech act has an influence on the thoughts, actions, or feelings of the listener in accordance with what was intended by the speaker. To answer these research questions, a qualitative research design was carried out. Data was collected from the language use of the main characters in Amy Tan's novel, The Joy Luck Club. Then, dialogues, monologues, and actions were collected, breed Sctibed, and analyzed. The results showed that the type and highest meaning used by the main character was representative. Meanwhile, in terms of form, most use declarative. Moreover, the perlocutionary acts produced are mostly ineffective. Keywords: Speech Act, Type, Meaning, Form, Illocutionary Act,
Short-Term Field Research on Air Pollution within the Boundaries of the Large City in the Baltic Region
Authors: Chlebnikovas Aleksandras , Paliulis Dainius , Bradulienė Jolita , Januševičius Tomas 
Published: May 2022

Abstract
Air quality in urban and suburban areas is strongly affected by the level of local urbanization, climatic conditions and industrial activity. Monitoring the main air pollutants such as nitrоgеn оxidеs, cаrbоn mоnоxide and particulatе mаttеr may help control thе most polluted areas of the site and take measures to reduce pollution. Uncontrolled emissions from other chemical pollutants, including volatile organic compounds and odorous contamination sources like ammonia may cause both a chronic human disease and damage to flora and fauna. The conducted field research is aimed at determining air pollution within the areas of the large city (residential territory, recreation territory and the areas close to intense transport streets) polluted with the gaseous pollutants of varying nature (CO, NO2, ozone, sulfur dioxide, VOC and NH3) as well as particulate matter in different seasons of the year. Studies on Vilnius district air quality were carried out in 17 urban locations (points) and based on two-phase measurements. The first phase was initiated in 2016–2017 and the second one took place in 2019–2020. It was observed that in the areas close to intense transport streets, the concentration of pollutants can increase more than 3 times, thus reaching up to 36.0 µg/m3 of PM10 (particulate matter) and up to 48.0 µg/m3 of nitrogen dioxide. During the summer period, ammonia concentrations can increase up to 3 times, reaching up to 11.0 µg/m3 from farming and/or industrial activities.
Spontaneous rupture of renal angiomyolipoma in twin pregnancy, surgical management with fetal preservation: a case report
Authors: Rulaniya Suresh , Neniwal Vishal , Bhalothia Shweta , Agarwal Piyush , Hota Datteswar 
Published: May 2022

Abstract
Introduction: Renal Angiomyolipomas are rare in pregnancy.They have tendency to grow in size leads to rupture and occasionally fatal because of hormonal imbalance. Our case report is aim to report the management strategy during first week of pregnancy. Case presentation: A 29 years female presented in her 11 weeks of gestation following ovulation induction with right flank pain which increased in severity recently.Radiological scans revealed 16x12 cm expanding mass suggestive of ruptured right renal AML. We have managed with a multidisciplinary approach and right open nephrectomy was performed in lieu of symptoms with serial ultrasound showed increased retroperitoneal collection in size. The histopathology revealed renal angiomyolipoma. On table and postoperative obstetrics scan revealed two live fetuses without any stress. Letter cesarean section was performed at 35 weeks without any complications. Conclusion: Ruptured renal angiomyolipoma is rarer with twin pregnancy.Multidisciplinary approach resulted in successful nephrectomy without concurrent delivery, allowing the pregnancy to proceed to term.
Mental Health First Aid Experiences: A Qualitative Investigation into the Emotional Impact of Mental Health First Aid Responsibilities
Authors: Cook Amy , Keyte Rebecca , Sprawson Isabella , Matharu Amrita , Mantzios Michail 
Published: May 2022

Abstract
Mental health is leading to rising costs to the economy and increasing strain on professional healthcare services. Mental Health First Aid (MHFA) is an effective tool to support people with ill mental health. This study explored the experiences of MHFA volunteers to increase knowledge of how to support them. Twelve students who had successfully completed the two-day MHFA training course participated in a semi-structured interview. Being a Mental Health First Aider (MHFAer) was a responsibility highly valued by participants, however the anxiety that accompanies this role was paramount within the data. It was clear to see the compassionate nature of MHFAers, however it was apparent that for many participants this was at the expense of self-compassion. This study suggests a need to enhance the support materials for MHFA volunteers, alongside a model of compassionate self-care for enhancing personal coping, health and wellbeing.
The zinc ionophore clioquinol reduces Parkinson’s disease patient-derived brain extracts-induced neurodegeneration
Authors: Teil Margaux , Doudnikoff Evelyne , Thiolat Marie-Laure , Bohic Sylvain , Bezard Erwan , Dehay Benjamin 
Published: May 2022

Abstract
Parkinson’s Disease (PD) is characterized by intracellular α-synuclein-rich protein aggregates, named Lewy Bodies (LB), and by the progressive loss of dopaminergic neurons in the substantia nigra. Several heavy metals, including zinc (Zn), have been suggested to play a role in PD progression, although the exact role of Zn in neurodegeneration remains to be fully elucidated. To address this gap, we investigated the effects of Zn modulation on the progression of degeneration in mice injected with PD patient-derived LB-extracts carrying toxic α-synuclein aggregates. Zn modulation was achieved using either a clioquinol-enriched diet, a Zn ionophore that redistributes cellular Zn, or a Zn-enriched diet that increases Zn levels. Clioquinol treatment significantly prevented dopaminergic neurodegeneration and reduced α-synuclein-associated pathology in LB-injected mice, while no differences were observed with Zn supplementation. Biochemical analyses further demonstrate that the expression levels of vesicle-specific Zn transporter ZnT3 in the striatum of LB-injected mice treated with clioquinol were decreased, suggesting an intracellular redistribution of Zn. Additionally, we found that clioquinol modulates the autophagy-lysosomal pathway by enhancing lysosomal redistribution within the neuronal compartments. Collectively, we found that in vivo pharmacological chelation of Zn, by dampening Zn-mediated cytotoxicity, can result in an overall attenuation of PD-linked lysosomal alterations and dopaminergic neurodegeneration. The results support zinc chelation as a disease-modifying strategy for treating PD.
SIRT4 functions as a tumor suppressor in prostate cancer by inducing apoptosis and inhibiting glutamine metabolism
Authors: Cai Liangliang , Ge Zhuhui , Xu Yunqiu , Sun Pingliang , Huang Guoyu 
Published: May 2022

Abstract
SIRT4, localized in the mitochondria, is an nicotinamide adenine dinucleotide (NAD+) -dependent adenosine diphosphate (ADP) -ribosyltransferase and is one of the least characterized members of the sirtuin family. Although it is well known that it shows deacetylase activity for energy metabolism, little is understood about its function in tumorigenesis. Recent research suggests that SIRT4 may work as both a tumor suppressor gene and an oncogene. However, the clinical significance of SIRT4 in prostate cancer remains unknown. In this study, we evaluated SIRT4 protein levels in cancerous prostate tissue and corresponding non-tumor prostate tissue via immunohistochemical staining on a tissue microarray including tissues from 89 prostate cancer patients. The association between SIRT4 expression and Gleason score was also determined. Further, shSIRT4 or stable prostate cancer cell lines (22RV1) overexpressing SIRT4 were constructed via lentiviral infection. Using Cell-Counting Kit-8 (CCK-8) assay, wound healing assay, migration, and invasion and apoptosis assays, the effects of SIRT4 on the migration, invasion ability, and proliferation of prostate cancer cells were investigated. We also determined the effect of SIRT4 on glutamine metabolism in 22RV1 cells. We found the protein levels of SIRT4 in prostate cancer tissues were significantly lower than those in their non-neoplastic tissue counterparts (P < 0.01); a lower SIRT4 level was also significantly associated with a higher Gleason score (P < 0.01). SIRT4 suppressed the migration, invasion capabilities, and proliferation of prostate cancer cells and induced cellular apoptosis. Furthermore, the invasion and migration of 22RV1 cells were mechanistically inhibited by SIRT4 via glutamine metabolism inhibition. In conclusion, the present study's findings showed that SIRT4 protein levels are significantly associated with the Gleason score in patients with prostate cancer, and SIRT4 exerts a tumor-suppressive effect on prostate cancer cells by inhibiting glutamine metabolism. Thus, SIRT4 may serve as a potential novel therapeutic target for prostate cancer.