bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vegetation‐related influences on carbon and water dynamics of two temperate forage crops
Authors: De Haan Kevin , Khomik Myroslava , Kessel Eric , Green Adam , Kompanizare Mazda , Helgason Warren , Macrae Merrin L. , Petrone Richard M. 
Published: April 2022

AbstractImproving understanding of how water use efficiency (WUE), evapotranspiration (ET), and gross primary productivity (GPP) (CO2 exchange) vary across agricultural systems can help farmers better prepare for an uncertain future due to climate change by assessing water requirements for a crop as a function of current environmental conditions. This study: (a) quantified field‐scale plant–water–carbon dynamics for silage maize (Zea mays L.) and alfalfa (Medicago sativa L.) crops – two dominant forage crops in southern Ontario, Canada; and (b) identified differences in plant carbon–water dynamics between these two crops, relating these differences to vegetation‐driven ecosystem controls. Climate and soil properties were similar between the two study sites, and water availability was not limiting, suggesting that the overall temporal differences in carbon–water relations were driven by vegetation differences, mainly crop choice and management practices. Alfalfa had greater seasonal GPP, ET, and WUE than maize, due to a longer growing season. Differences in daily WUE between maize and alfalfa were driven by differences in GPP rather than ET. Multiple harvests reduced leaf‐aging effects and promoted periods of rapid growth in alfalfa. In contrast, late seedling emergence and self‐shading reduced GPP in maize. Under a warmer future climate, crop selection (i.e., perennial vs. annual), harvest regimes, and changes in growing season length should be considered when trying to manage for increased WUE. However, longer duration studies to validate these results are required to better address the impacts of climatic variability—especially antecedent conditions—to better inform future crop choices within a climate change context.
Stabile Ambipolare Heptacene und deren Redox‐Spezies
Authors: Zeitter Nico , Hippchen Nikolai , Maier Steffen , Rominger Frank , Dreuw Andreas , Freudenberg Jan , Bunz Uwe H. F. 
Published: April 2022

AbstractDurch sechsfache TIPS‐Ethinylierung, kombiniert mit vierfacher Bromierung des Acen‐Rückgrats, wurde ein langlebiges, lösliches Heptacen erhalten; mittels Stille‐Kupplung wurde das π‐System zu einem langlebigen Tetrabenzononacen erweitert. Durch die Einführung von TIPS‐Ethinylgruppen an jedem zweiten Benzolring wurden für beide Arten von Acenen besonders hohe Stabilitäten festgestellt. Das Tetrabromheptacen ist ein ambipolares Transistormaterial (bis zu 0.036 cm2 V−1 s−1 im n‐Kanal), was durch die Erzeugung seines Monoanions und Monokations bestätigt werden konnte.
Zur Alterung von barocken Putzlattendecken
Authors: Müller David , Schütz Karl G. , Mohr Bernhard 
Published: April 2022

AbstractIm süddeutschen Raum sind viele Kirchen von flachen Putzdecken überspannt. In den vergangenen Jahren kam es vermehrt zu Teilabstürzen an diesen Decken. Konstruktive Mängel bei der Herstellung oder statische Mängel am Tragwerk können Gründe hierfür sein. Darüber hinaus lassen die verwendeten Materialien mit sehr unterschiedlichen Eigenschaften auf einen Alterungsprozess schließen. Um diesen nachzuweisen, wird ein statisches Modell aufgebaut und die Beanspruchung infolge Quellen, Schwinden und Temperaturänderungen als Last aufgebracht. Die Berechnungen zeigen, dass es hierdurch zu Spannungen in der Putzdecke kommt. Durch das Schwinden der Holzlatte entstehen zwischen Holz und Putz nicht aufnehmbare Zugspannungen, sodass es zum Abriss des Putzes von der Latte kommt. Hierbei lösen sich Putzpartikel, die in den Zwischenraum zwischen Holz und Steg fallen. Beim Quellen der Holzlatten entstehen Druckspannungen senkrecht zum Steg. Die Putzpartikel im Zwischenraum behindern das Quellen, wodurch Spaltzugkräfte entstehen, die zu einer Rissbildung führen. Dieser Vorgang wiederholt sich bei barocken Putzdecken jährlich über einen Zeitraum von ca. 300 Jahren. Es kommt zu einem stetigen Anstieg der Spannungen, sodass von einem Alterungsprozess der Putzlattendecken gesprochen werden kann.
Development and validation of an LC–MS/MS method for simultaneous determination of remdesivir and its hydrolyzed metabolite and nucleoside, and its application in a pharmacokinetic study of normal and diabetic nephropathy mice
Authors: Yuan Meng , Hu Wenjuan , Feng Yingying , Tong Yue , Wang Xin , Tan Bo , Xu Hui , Liu Jia 
Published: April 2022

AbstractRemdesivir (RDV), a phosphoramidate prodrug, has broad‐spectrum antiviral activity. It is the first antiviral drug approved by the US Food and Drug Administration (FDA) for the treatment of COVID‐19. Remdesivir is rapidly metabolized in the body to produce derivatives: alanine metabolite (RM‐442) and RDV C‐nucleoside (RN). Here, the phosphatase inhibitor PhosSTOP and carboxylesterase inhibitor 5,5′‐dithiobis‐2‐nitrobenzoic acid were used to improve stability of RDV in mouse blood. We developed a rapid and sensitive LC–MS/MS method to simultaneously quantify RDV, RM‐442 and RN in mouse blood. Chromatographic separation was achieved by gradient elution on an Acquity HSS T3 column. The run time was 3.2 min. The linearity ranges of the analytes were 0.5–1,000 ng/ml for RDV and 5–10,000 ng/ml for both RM‐442 and RN. The method had an acceptable precision (RSD < 8.4% for RDV, RSD < 10.7% for RM‐442 and RSD < 7.2% for RN) and accuracy (91.0–106.3% for RDV, 92.5–98.6% for RM‐442 and 87.5–98.4% for RN). This method was successfully applied to analyze RDV, RM‐442 and RN in the blood of normal and diabetic nephropathy DBA/2 J mice after intravenous injection of RDV at 20 mg/kg. The area under the concentration–time curve of RN between the normal and diabetic nephropathy mice showed a significant difference (P < 0.01).
Determining the effectiveness of cognitive behavioral therapy interventions based on the transdiagnostic approach in the treatment of common mental health problems: Presenting an experience from the Islamic Republic of Iran
Authors: Falahat Katayoun , Baradarn Eftekhari Monir , Dejman Masoumeh , Forouzan Ameneh Setareh , Mahmoodi Zohreh , Padyab Mojgan , Tavassoli Samira 
Published: April 2022

AbstractIntroductionThere is growing support to develop transdiagnostic approaches that provide new insights into mental health problems and cut across the existing traditional diagnostic boundaries all over the world. The present study was conducted to test the transdiagnostic cognitive behavioral therapy (TCBT) approach in treating patients with common mental health problems and evaluate its effectiveness compared to the current treatment settings of the healthcare system.MethodsA randomized controlled trial was conducted in Semnan Province, north of Iran. The study took pace in urban health centers. A sample of 520 Iranian adults, tested as positive on the Kessler Psychological Distress Scale, were enrolled. Participants who received a score above the cut‐off point in any of the three mental health disorders (depression, anxiety, or obsessive compulsive disorder [OCD]) based on the locally validated study instrument were randomly allocated to the study. The intervention group received TCBT during eight sessions provided by trained general health service providers without previous mental health training; the standby control group received Mental Health Services as Usual (MHSU). The post‐test interviews were conducted using the study instrument after the completion of both group treatments.ResultsA total of 459 individuals (87.8% female) ultimately entered the study. The withdrawal rate was 24% (53 participants in the TCBT and 56 in the MHSU). Reduction in depression, anxiety, and OCD symptoms was significant within each group and when comparing TCBT and MHSU (mean difference).ConclusionThis trial recommends that the transdiagnostic CBT approach can be effective in improving common mental health problems and functions among individuals by trained general healthcare providers in the primary healthcare system. The results can be more useful in decision making when defining the process of providing mental healthcare in the National Primary Healthcare System.
From offline learning to online learning: Moderating effect of relationship inertia and satisfaction
Authors: Liu Jinfa 
Published: April 2022

AbstractThe progress of educational technology and the demand of home learning under COVID‐19 have promoted the rapid development of online learning all over the world. The existing research focuses on offline learning or online learning but seldom discusses their switching process. This paper uses the questionnaire method and structural equation model to analyze the influencing factors of switching intention and behavior from offline learning to online learning. The results show that the switching intention is significantly affected by perceived usefulness, perceived ease of use, and computer self‐efficacy, and negatively affected by the perceived risk. The switching intention makes a significant positive effect on switching behavior. When the learner's offline learning relationship inertia and satisfaction are higher, the relationship between switching intention and switching behavior will be weakened. At the end of the paper, some suggestions are put forward for reference for the related parties of online learning.
Implications of using classroom response systems (CRS) on learning performance: An experience of learning analytics
Authors: Garcia‐Lopez Eva , Garcia‐Cabot Antonio 
Published: April 2022

AbstractThe increasing use of technology among new generations of students provides a unique opportunity to take advantage of its multiple benefits in the academic environment. For example, mobile devices can be used in the learning process to improve academic results on learners' engagement or to decrease the dropout rate among students. This study seeks to analyze the impact that the implementation of a Classroom Response System (CRS) such as Kahoot could have on the development of a university subject in the Computer Science Degree and Computer Engineering Degree. More specifically, the research is conducted in the subject of “Advanced Programming” and performs three main studies by comparing the results in five different assessment items in two different academic courses (control and experimental): The first one seeks to determine the impact that a CRS produces on academic performance, the second one analyzes the impact of a CRS on the dropout rate of students and finally, the third study analyzes the impact of a CRS according to whether the student is a first‐time student or a repeater one. The results show that using CRS improves academic performance in almost all cases, except for the most demanding exam. This also applies to first‐time enrolled students. However, for repeat students, in addition to this, their academic performance could not be either demonstrated in the laboratory part. Finally, in all cases (general, first‐time, and repeaters) the dropout rate was decreased (i.e., improved) only in the last exam.
Cross‐disciplinary curriculum integration spaces for emergency management engineering talent cultivation in higher education
Authors: Wei Yao‐Yao , Chen Wei‐Fan , Xie Tian , Peng Jian‐Jun 
Published: April 2022

AbstractCultivating cross‐disciplinary emergency management engineering talent is necessary and significant for responding to major emergencies. As barriers to intercourse and cognition exist between the different disciplines, the massive, heterogeneous, unordered cross‐disciplinary curricula are difficult to integrate. To solve these problems and integrate the courses from various disciplinary curriculum plans on demand, the cross‐disciplinary curriculum integration spaces (CCIS) method is proposed based on the cross‐domain integrating and reasoning spaces method and IOPE model. First, using space modeling, the key structure of cross‐disciplinary talent demand and various curriculum plans can be dimensionally transformed and formally expressed in the CCIS spaces. Second, to solve possible semantic inconsistencies between curriculum plans from different disciplines, relevant interoperable mediating methods are present. Furthermore, the inputs‐outputs‐preconditions‐effects (IOPE)‐based integration algorithm of CCIS spaces is proposed to integrate and reorganize the disciplinary curriculum plans into the optimized cross‐disciplinary curriculum plans according to a new talent demand. Two applied examples and their experiment results show that the reliable and valid cross‐disciplinary curriculum plan for responding to the compound talent demand can be obtained with the proposed CCIS method.
Identification and validation of a ferroptosis‐related gene signature for predicting survival in skin cutaneous melanoma
Authors: Ping Shuai , Wang Siyuan , Zhao Yingsong , He Jinbing , Li Guanglei , Li Dinglin , Wei Zhuo , Chen Jianghai 
Published: April 2022

AbstractPurposeFerroptosis plays a crucial role in the initiation and progression of melanoma. This study developed a robust signature with ferroptosis‐related genes (FRGs) and assessed the ability of this signature to predict OS in patients with skin cutaneous melanoma (SKCM).MethodsRNA‐sequencing data and clinical information of melanoma patients were extracted from TCGA, GEO, and GTEx. Univariate, multivariate, and LASSO regression analyses were conducted to identify the gene signature. A 10 FRG signature was an independent and strong predictor of survival. The predictive performance was assessed using ROC curve. The functions of this gene signature were assessed by GO and KEGG analysis. The statuses of low‐risk and high‐risk groups according to the gene signature were compared by GSEA. In addition, we investigated the possible relationship of FRGs with immunotherapy efficacy.ResultsA prognostic signature with 10 FRGs (CYBB, IFNG, FBXW7, ARNTL, PROM2, GPX2, JDP2, SLC7A5, TUBE1, and HAMP) was identified by Cox regression analysis. This signature had a higher prediction efficiency than clinicopathological features (AUC = 0.70). The enrichment analyses of DEGs indicated that ferroptosis‐related immune pathways were largely enriched. Furthermore, GSEA showed that ferroptosis was associated with immunosuppression in the high‐risk group. Finally, immune checkpoints such as PDCD‐1 (PD‐1), CTLA4, CD274 (PD‐L1), and LAG3 were also differential expression in two risk groups.ConclusionsThe 10 FRGs signature were a strong predictor of OS in SKCM and could be used to predict therapeutic targets for melanoma.
Construction and validation of a prognostic model for kidney renal clear cell carcinoma based on podocyte‐associated genes
Authors: Chen Can , Yang Rui‐Xia , Zhang Jie‐Xin , Xu Hua‐Guo 
Published: April 2022

AbstractBackgroundAs the most common renal malignancy, kidney renal clear cell carcinoma (KIRC) has a high prevalence and death rate as well as a poor response to treatment. Developing an efficient prognostic model is essential for accurately predicting the outcome and therapeutic benefit of KIRC patients.MethodsGene expression profiles of podocyte‐associated genes (PAGs) were obtained from The Cancer Genome Atlas and GEO datasets. Cox regression and Lasso regression analyses were then used for filtering prognosis‐associated PAGs. Risk score (RS) was computed from these genetic characteristics. Kaplan–Meier analysis and receiver operating characteristic (ROC) curves were applied for ascertaining the prognostic value. Stratified analysis was used to sufficiently validate model performance. Concordance index was used to compare the predictive ability of different models. Immuno‐infiltration analysis and immunophenoscore were utilized for the prediction of patient reaction to immune checkpoint inhibitors (ICIs).ResultsWT1, ANLN, CUBN, OSGEP, and RHOA were significantly associated with KIRC prognosis. Prognostic analysis indicated that high‐RS patients have a significantly poorer outcome. Cox regression analysis demonstrated a potential for RS to be an independent prognostic factor. Pathway enrichment results indicated a lower enrichment of cancer‐related biological pathways in the low‐RS subgroup. Immune infiltration analysis and IPS demonstrated greater responsiveness to ICIs in the high RS group.ConclusionsThis podocyte‐associated KIRC prognostic model can effectively predict KIRC prognosis and immunotherapy response, which may help to provide clinicians with more effective treatment strategies.
Broadening the Scope of the Flavin‐Tag Method by Improving Flavin Incorporation and Incorporating Flavin Analogs
Authors: Tong Yapei , Loonstra Marnix R. , Fraaije Marco W. 
Published: April 2022

AbstractMethods for facile site‐selective modifications of proteins are in high demand. We have recently shown that a flavin transferase can be used for site‐specific covalent attachment of a chromo‐ and fluorogenic flavin (FMN) to any targeted protein. Although this Flavin‐tag method resulted in efficient labeling of proteins in vitro, labelling in E. coli cells resulted in partial flavin incorporation. It was also restricted in the type of installed label with only one type of flavin, FMN, being incorporated. Here, we report on an extension of the Flavin‐tag method that addresses previous limitations. We demonstrate that co‐expression of FAD synthetase improves the flavin incorporation efficiency, allowing complete flavin‐labeling of a target protein in E. coli cells. Furthermore, we have found that various flavin derivatives and even a nicotinamide can be covalently attached to a target protein, rendering this method even more versatile and valuable.
Effect of particle size, flour:water ratio and type of pulse on the physicochemical and functional properties of wet protein extraction
Authors: Higa Federica A. , Boyd Lindsey , Sopiwnyk Elaine , Nickerson Michael T. 
Published: April 2022

AbstractBackground and ObjectivesExtraction of proteins by alkaline extraction followed by isoelectric precipitation at three different flour: water (f:w) ratios (1:10, 1:7, and 1:5) were investigated for four pulse flours: yellow pea (YP), green lentil (GL), kabuli chickpea (CH), and navy bean (NB). Pulse flours were prepared by pre‐breaking the seeds and milling into flour using a Ferkar (knife) mill with either a 0.5 mm (P1) or 1.27 mm (P2) screen. Surface properties and functionality of the protein concentrates were evaluated.FindingsExtraction yields showed no major differences between the investigated f:w ratios. Protein yields decreased significantly as the amount of water decreased. The 1:10 f:w ratio was selected to perform extractions with coarser flours (1.27 mm; P2). Results showed that flour with a smaller particle size increased yields by 0.4% to 3.2% for extraction, and 7.9%–10.3% for protein. Functional properties showed no major differences between proteins extracted at different f:w ratios, although differences were found between the different pulse types. In some cases, P2 and P1 concentrates differed in functional properties, but this was not consistent for all pulses.ConclusionsFiner flour (P1) and higher f:w ratio (1:10) resulted in higher extraction and protein yields.Significance and NoveltyThis study highlights the importance of milling and control of the particle size of the flours and water use on the preparation of protein concentrates.
Cutaneous allergic reaction correlates with anti‐erythropoietin antibodies in dialysis patient developing pure red cell aplasia
Authors: Badiu Iuliana , Diena Davide , Guida Giuseppe , Ferrando Carlo , Rapezzi Davide , Besso Luca 
Published: April 2022

AbstractWe describe a case of concomitant erythropoietin allergy and resistance with a possible IgE and IgG‐mediated immune response, in which the local allergic cutaneous symptoms preceded the antibody‐mediated anemia.
Reversible global hypoperfusion in an adult patient with a mixed diabetic ketoacidosis/hyperglycemic hyperosmolar coma: A case report
Authors: Petroulia Valentina Dafni , Kurmann Christoph , Haenggi Matthias , Wagner Franca , Hakim Arsany 
Published: April 2022

AbstractDiabetic ketoacidosis is a severe complication of diabetes mellitus. We report a case of global hypoperfusion in an elderly patient on CT, with complete resolution shown on early MRI follow‐up. Metabolic causes have always to be included in the differential diagnosis of diffuse hypoperfusion in the appropriate clinical setting.
Prostate cancer dural metastasis resembling a meningioma
Authors: Shimada Hitomi , Tago Masaki 
Published: April 2022

AbstractCT images of a 56‐year‐old man with headache showed a meningioma‐like mass in the occipital region. The tumor was well‐defined and non‐uniform with bone thickening and no internal calcification. Eventually, he was diagnosed on the basis of histopathology and immunostaining findings as having a dural metastasis from a prostate cancer.
Bilateral posterior lamellar corneal transplant surgery in an infant of 17 weeks old: Surgical challenges and the added value of intraoperative optical coherence tomography
Authors: Muijzer Marc B. , Kroes Hester Y. , van Hasselt Peter M. , Wisse Robert P. L. 
Published: April 2022

AbstractThis study aimed to describe the surgical challenges, management, and value of intraoperative optical coherence tomography in a case of a bilateral Descemet Stripping Automated Endothelial Keratoplasty corneal transplantation at 17 weeks of age for the treatment of severe posterior polymorphous corneal dystrophy resulting from a de novo mutation of the OVOL2‐gene.
Compound‐complex odontoma: A rare case report
Authors: Khalifa Chaima , Omami Mounir , Garma Maroua , Slim Afef , Sioud Sameh , Selmi Jamil 
Published: April 2022

AbstractThe World Health Organization (WHO) classifies odontomas as odontogenic tumors, consisting of odontogenic epithelium and ectomesenchyme. They result from developmental abnormalities and, therefore, do not constitute authentic tumors. It is a local malformation that has no growth autonomy. They are rarely symptomatic and are usually discovered accidentally during the realization of a radiographic examination. There are two variants of odontomas: complex and compound. Complex odontomas are made of a mass consisting of an anarchic assembly of mineralized tissue (enamel, dentin, and cementum) and dental pulp; while compound odontomas are consisting of a set of small rudimentary teeth, assembling in clusters. They rarely show the features of both types together. The aim of this work is to report a rare presentation of an odontoma in a 24‐year‐old male patient, which present the characteristics of both complex and compound variants. Surgical excision of the lesion was performed. Anatomopathological examination confirmed the diagnosis. Clinical and radiological survey does not show any recurrence.
Atlantoaxial instability and cervical noninfectious spondylodiscitis in a patient with Wegener’s granulomatosis: A case report
Authors: Rezvani Majid , Sabouri Masih , Aminmansour Bahram , Tabesh Homayoun , Shafiei Mehdi , Mahmoodkhani Mehdi , Rahmani Peiman , Falahpour Soheil , Sourani Arman , Mahdavi Sadegh Baradaran 
Published: April 2022

AbstractA 61‐year‐old male patient with Wegener's granulomatosis was admitted due to neck pain and quadriparesis. Clinical evaluation showed severe cervical noninfectious spondylodiscitis, myelopathy, sagittal imbalance, and atlantoaxial instability. A combined anterior and posterior approach was implemented. Postoperative clinical evaluation showed improved neurologic status.