bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of exercise-based home pulmonary rehabilitation on patients with chronic obstructive pulmonary disease: An overview of systematic review
Authors: Zheng Jiang , Zhang Zhi , Han Ruijuan , Zhang Hongxia , Deng Jie , Chai Meimei 
Published: November 2022

Background
Clinical research on exercise-based home pulmonary rehabilitation (HPR) effectiveness in chronic obstructive pulmonary disease (COPD) treatment is rising, as are associated systematic reviews/meta-analyses (SRs/MAs). However, different SRs/MAs vary in outcome indicators, analysis methodologies, literature quality, and findings. This overview aimed to describe the findings of these SRs/MAs and assess their methodological quality.

Methods
From inception until April 2022, we searched PubMed, Web of Science, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), and Wan Fang. Two researchers searched these SRs/MAs separately, collected the data, and cross-checked it using predetermined rules. The Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR 2) was used to evaluate the methodological quality of each contained SR/MA. The evidence was assessed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2009 (PRISMA-2009). The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) was used to determine the validity of the results.

Results
A total of 433 records were found, with 44 chosen for full-text review. There were 11 SRs/MAs that matched the inclusion criteria. Our overview included studies published from 2010 to 2022. According to the AMSTAR 2 tool, one had low methodological quality, while the other 10 SRs/MAs had very low quality. The PRISMA statement revealed a low rate of complete reporting for eight items. The GRADE tool, on the other hand, revealed that the evidence quality for most outcomes was very low to moderate.

Conclusion
According to current research, exercise-based HPR may benefit COPD patients. Nevertheless, this finding is restricted by the low quality of the included SRs/MAs. And more high-quality and large-sample studies are needed in the future.

Prospero
ID: CRD42022322768. https://www.crd.york.ac.uk/prospero/#recordDetails
Incidence of extubation failure and its predictors among adult patients in intensive care unit of low-resource setting: A prospective observational study
Authors: Kifle Natnael , Zewdu Dereje , Abebe Bisrat , Tantu Temesgen , Wondwosen Mekete , Hailu Yirgalem , Bekele Girma , Woldetensay Meron 
Published: November 2022

Background
Previous studies have found an association between various predictors and extubation failure (EF) in intensive care units (ICUs). However, this problem remains unexplored in low-resource settings, where predicting the extubation outcomes are more challenging. This study investigates the incidence of EF and its predictors among patients who received mechanical ventilation (MV).

Methods
This is a prospective observational study of 123 patients’ ≥ 18 years of age receiving MV for ≥ 48 hours and tolerated spontaneous breathing trials (SBTs) in the ICU of a low-resource setting. We collected data on the baseline characteristics and clinical profiles before and after SBTs. Patients were categorized into extubation failure (EF) and extubation success (ES) groups. Multivariate logistic regression analyses were performed to identify independent predictors for EF. A p-value < 0.05 is considered statistically significant.

Results
We included 123 patients, and 42 (34.15%) had developed EF. The identified predictors for EF: Moderate to copious secretions (adjusted odds ratio [AOR]: 3.483 [95% confidence interval [CI] 1.10–11.4]), age > 60 years of age ([AOR]: 4.157 [95% CI 1.38–12.48]), and prolonged duration of MV ≥ 10 days ([AOR]: 4.77 [95% CI 1.55–14.66]).

Conclusion
Moderate to copious secretions, patients > 60 years of age, and prolonged duration of MV ≥ 10 days were the best predictors of EF. Based on our findings, we recommend that the identified predictors could help in the decision-making process of extubation from MV.
Lower academic performance and dropout rates among University students with children: a prospective cohort study of nursing students in Bogotá, Colombia
Authors: Cortés-Muñoz Fabián , Garzón Ruiz Jenny Paola , Ferrer Buenaño Mónica Alexandra , Fonseca Granados Laura Daniela , Agudelo Cruz Luis Fernando , Lombana Cortés John Jalber , Ruiz Barrera Jennifer Tatiana , Parada Fresneda Angie Paola , Quimbay Mondragón José Luis , Buitrago Arcila Johan Stiven , Gil Cabezas Mateo Alejandro 
Published: November 2022

Abstract

Objectives
To determine the association between parenthood and academic performance and dropout among professional Nursing degree program students.

Methods
A prospective cohort was conducted. 310 students were included, 26 parents (exposed) and 284 nonparents (unexposed), who were followed up during 16 weeks. At the end of this follow-up, student records were reviewed.

Results
Academic performance in the exposed and unexposed groups was 3.51/5.0 and 3.64/5.0 respectively. Although it was higher in the latter group, i.e., with a difference of 0.13, the values were not statistically significant (p=0.058). After adjusting for confounding variables, a difference of −0.165 point was seen (p=0.037). The risk of students dropping out of college is 34 % less for exposed compared to those who are unexposed (RR: 0.66; CI: 0.075–5.78; p=0.708).

Conclusion
The results suggest that parenthood has a modest impact on the academic performance, and has no impact on the risk of dropping out.
A generalized double robust Bayesian model averaging approach to causal effect estimation with application to the study of osteoporotic fractures
Authors: Talbot Denis , Beaudoin Claudia 
Published: November 2022

Abstract
Analysts often use data-driven approaches to supplement their knowledge when selecting covariates for effect estimation. Multiple variable selection procedures for causal effect estimation have been devised in recent years, but additional developments are still required to adequately address the needs of analysts. We propose a generalized Bayesian causal effect estimation (GBCEE) algorithm to perform variable selection and produce double robust (DR) estimates of causal effects for binary or continuous exposures and outcomes. GBCEE employs a prior distribution that targets the selection of true confounders and predictors of the outcome for the unbiased estimation of causal effects with reduced standard errors. The Bayesian machinery allows GBCEE to directly produce inferences for its estimate. In simulations, GBCEE was observed to perform similarly or to outperform DR alternatives. Its ability to directly produce inferences is also an important advantage from a computational perspective. The method is finally illustrated for the estimation of the effect of meeting physical activity recommendations on the risk of hip or upper-leg fractures among older women in the study of osteoporotic fractures. The 95% confidence interval produced by GBCEE is 61% narrower than that of a DR estimator adjusting for all potential confounders in this illustration.
The evolution of pituitary cysts in growth hormone-treated children
Authors: Krasnow Matthew D. , Krasnow Nicholas A. , McGuirk Liam , Patale Tara P. , Manely Sarah , Sayegh Emily , Epstein Benjamin , Hanif Sarriyah A. , Mehta Shilpa , Tenner Michael , Schefflein Javin , Mehta Hasit , Noto Richard A. 
Published: November 2022

Abstract

Objectives
We have previously shown that pituitary cysts may affect growth hormone secretion. This study sought to determine cyst evolution during growth hormone treatment in children.

Methods
Forty-nine patients with short stature, a pituitary cyst, and at least two brain MRI scans were included. The percent of the pituitary gland occupied by the cyst (POGO) was calculated, and a cyst with a POGO of ≤15% was considered small, while a POGO >15% was considered large.

Results
Thirty-five cysts were small, and 14 were large. Five of the 35 small cysts grew into large cysts, while 6 of the 14 large cysts shrunk into small cysts. Of 4 cysts that fluctuated between large and small, 3 presented as large and 1 as small. Small cysts experienced greater change in cyst volume (CV) (mean=61.5%) than large cysts (mean=−0.4%). However, large cysts had a greater net change in CV (mean=44.2 mm3) than small cysts (mean=21.0 mm3). Older patients had significantly larger mean pituitary volume than younger patients (435.4 mm3 vs. 317.9 mm3) and significantly larger mean CV than younger patients (77.4 mm3 vs. 45.2 mm3), but there was no significant difference in POGO between groups.

Conclusions
Pituitary cyst size can vary greatly over time. Determination of POGO over time is a useful marker for determining the possibility of a pathologic effect on pituitary function since it factors both cyst and gland volume. Large cysts should be monitored closely, given their extreme, erratic behavior.
Prenatal care and pregnancy outcome among incarcerated pregnant individuals in the United States: a systematic review and meta-analysis
Authors: Hessami Kamran , Hutchinson-Colas Juana A. , Chervenak Frank A. , Shamshirsaz Alireza A. , Zargarzadeh Nikan , Norooznezhad Amir Hossein , Grünebaum Amos , Bachmann Gloria A. 
Published: November 2022

Abstract
This systematic review and meta-analysis assessed the risk of inadequate prenatal care and pregnancy outcome among incarcerated pregnant individuals in the United States. PubMed/MedLine, Embase, ClinicalTrials.gov and Web of Science were searched from inception up to March 30th, 2022. Studies were included if they reported the risk of inadequate prenatal care and/or pregnancy outcomes among incarcerated pregnant individuals in the United States jails or prisons. Adequacy of prenatal care was quantified by Kessner index. The random-effects model was used to pool the mean differences or odds ratios (OR) and the corresponding 95% confidence intervals (CIs) using RevMan software. Nine studies were included in the final review. A total of 11,534 pregnant individuals, of whom 2,544 were incarcerated while pregnant, and 8,990 who were matched non-incarcerated pregnant individuals serving as control group, were utilized. Compared to non-incarcerated pregnancies, incarcerated pregnant individuals were at higher risk of inadequate prenatal care (OR 2.99 [95% CI: 1.60, 5.61], p<0.001) and were more likely to have newborns with low birthweight (OR 1.66 [95% CI: 1.19, 2.32], p=0.003). There was no significant difference between incarcerated and matched control pregnancies in the rates of preterm birth and stillbirth. The findings of the current systematic review and meta-analysis suggest that incarcerated pregnant individuals have an increased risk of inadequate prenatal care. Considering the limited number of current studies, further research is indicated to both assess whether the risk of inadequate prenatal care has negative impact on prenatal outcomes for this population and to determine the steps that can be taken to enhance prenatal care for all pregnant individuals incarcerated in the United States prisons.
Evolutionary Dynamics of Armatures in Southern France in the Late Mesolithic and Early Neolithic
Authors: Defranould Elsa , Philibert Sylvie , Perrin Thomas 
Published: November 2022

Abstract
The use of weapons, and therefore of arrowheads, contributed to structuring the technical, economic, social and cultural domains. In the technical sphere, emblematic projectile armatures are often considered to be loaded with cultural values and to embody the expression of human group identity. The study of their variability, in time and space, can shed light on mechanisms of mutation and innovation stemming from adaptative strategies and cultural choices. During the seventh and sixth millennia, the renewal of arrowheads corresponds to major changes in lithic equipment. Between the Late Mesolithic and the Early Neolithic, we observe a diversification of arrowhead shapes and the evolution of represented types. These observations enhance interpretative scenarios, especially questions concerning the transfer of know-how, techno-economic renewal and neolithisation. This article proposes to study these changes at the sequence of the Baume de Montclus site, a key site in Southern France. The selected sequence covers 1.5 millennia of occupation, roughly from 6500 to 5000 cal. BCE, with a corpus of geometric bitruncations of about 650 pieces. The combined study of microwear and technological and typological data leads to a comprehensive interpretation of manufacturing processes, hafting methods and function. These analyses provide valuable information on the diversity of arrowheads, the identification of specific technical traditions and the characterisation of techno-functional ruptures throughout this sequence. These results will subsequently be integrated into a wider, regional and extra-regional context, with a particular focus on the emergence of blade and trapeze complexes (BTC) and the neolithisation of the western Mediterranean basin.
Arminiani e sociniani nel Seicento: rifiuto o reinterpretazione del cristianesimo sacrificale?
Authors: Brogi Stefano 
Published: November 2022

Abstract
The terms „Socinian“ and „Arminian“ (despite their often equivocal and polyvalent use) refer primarily to the members of two small Christian communities viewed with great suspicion by the established churches: the Ecclesia minor of the Polish Brethren, on the one hand, and the Dutch Remonstrant Brotherhood, on the other. These were two numerically small and marginalized groups, but capable of influencing substantial numbers of theologians and intellectuals of different denominational backgrounds in many European countries. The Dutch Remonstrants faced frequent allegations of Socinianism: far from diminishing over time, these charges became harsher and more insistent after the destruction of the Ecclesia minor and the resulting Socinian diaspora. However, this study shows that the relationship was not one-way: Arminius’ heirs in turn influenced those of Sozzini, as evidenced by the development of the two theological traditions on the crucial issue of Christ’s redemption and atonement. At the end of the seventeenth century, on this as on other subjects, the theories of the Remonstrants established some hegemony over the doctrinal elaborations of the successors to the Socinian tradition.
Nascita dei Comuni e memoria di Roma: un legame da riscoprire
Authors: Alberzoni Maria Pia 
Published: November 2022

Abstract
The historiography on the Italian Communes has investigated the motives behind the new city governments. Jean-Claude Maire Vigueur and Chris Wickham have stressed different rationales in the actions of the communal elites. However, we should avoid underestimating the cultural power of a model still very much present in the Middle Ages: imperial Rome. In the crisis linked to the struggle for investiture, city elites were inspired by the Roman institutional model, albeit following different ‚models‘ (classical, Byzantine, Carolingian and Saxon). The communal world interpreted this legacy with the contribution of the Roman Church. In this context, the use of spolia as an instrument of legitimization, stressed by Arnold Esch, should be re-evaluated. The interpretation in a Roman key of institutions, laws, political and artistic languages presupposed a sound cultural education on the part of the people of the commune, based on the classical tradition and, politically, on Roman law and institutions. These concepts were visually expressed in the new artistic style – later called the ‚Romanesque‘ due to the obvious desire to reinterpret classical models. Finally, the equestrian group of Oldrado da Tresseno (1233) on the facade of the Palazzo della Ragione in Milan, the only known example of this type of municipal political representation in the first half of the 13th century, allows us to assess the power of the Roman model in legitimising municipal policies.
In the Wings
Authors: Bortolotti Raphaël , Brunello Giulia , Kappeler Annette 
Published: November 2022

Abstract
The historical archive in Feltre (Veneto) preserves inventories of its Teatro Sociale that testify to this provincial theatre’s importance to the town and the surrounding area during the 19th century. These inventories are rare sources that have never previously been analysed. Based on these documents, this article investigates the world behind the scenes and extracts information on the staff involved in running the theatre. Offstage workers are generally forgotten on playbills and in theatre periodicals (which pay tribute to onstage artists and report the repertoire of travelling theatre companies), and they do not figure significantly in the documents of theatre companies such as contracts, correspondence and regulations. To a greater extent than other sources, these inventories provide a window onto the labour of these workers, who made a highly significant, if less visible, contribution to performances and the running of a theatre.
Die toskanische Weimar-Fraktion
Authors: Loyen Ulrich van 
Published: November 2022

Abstract
This article takes as its starting point Philipp Felsch’s recent book telling the intriguing story of how, from the 1960s, the two Italian scholars Giorgio Colli and Mazzino Montinari rediscovered and edited Nietzsche’s legacy, considered a highly problematic frame of reference in the aftermath of the Second World War. The essay outlines the Italian background – both institutional and ideological – of this enterprise. Additionally, it argues that Colli and Montinari’s philological scrutiny and quest for veracity also helped to lay the groundwork for the reception of such ‚non-binary‘ thinkers as Heidegger within political movements of both the (radical) left and right.
Ultrasonic supported dye removal by a novel biomass
Authors: Gülen Jale , Küçük İlknur , Yalçın Berrin Saygı , Çelik Selen Ezgi , Özgür Mahmure 
Published: November 2022

Abstract
Sumac Leaves (Rhus Coriaria L), were used as a possible adsorbent of Basic Blue 3 (BB3) removal. The main affecting parameters on adsorption such as concentration, pH and temperature were investigated. Adsorption equilibrium was reached in 30 min. The ultrasonic effect was also enhanced the dyestuff removal. Adsorption capacity was rised from 0.566 to 1.826 mg/g, as rising the concentration from 4 μg/mL to 10 μg/mL. Several isotherm models including Langmuir, Freundlich and Temkin were applied for explaining the adsorption mechanism. Temkin and Langmuir isotherm models describe the system well. Pseudo first order, pseudo second order and intra particle kinetics were evaluated. Pseudo second order diffusion model supports the adsoprption and also intra particle diffusion plays an important role for BB3 removal. Thermodynamics of the adsorption were commented. −2219.5 J/mol of Gibbs energy showed us a spontaneous and physical adsorption.
Differential Patterns of Synaptic Plasticity in the Nucleus Accumbens Caused by Continuous and Interrupted Morphine Exposure
Authors: Lefevre Emilia M. , Gauthier Elysia A. , Bystrom Lauren L. , Scheunemann Jordan , Rothwell Patrick E. 
Published: November 2022

Opioid exposure and withdrawal both cause adaptations in brain circuits that may contribute to abuse liability. These adaptations vary in magnitude and direction following different patterns of opioid exposure, but few studies have systematically manipulated the pattern of opioid administration while measuring neurobiological impact. In this study, we compared cellular and synaptic adaptations in the nucleus accumbens shell caused by morphine exposure that was either continuous or interrupted by daily bouts of naloxone-precipitated withdrawal. At the behavioral level, continuous morphine administration caused psychomotor tolerance, which was reversed when the continuity of morphine action was interrupted by naloxone-precipitated withdrawal. Usingex vivoslice electrophysiology in female and male mice, we investigated how these patterns of morphine administration altered intrinsic excitability and synaptic plasticity of medium spiny neurons (MSNs) expressing the D1 or D2 dopamine receptor. We found that morphine-evoked adaptations at excitatory synapses were predominately conserved between patterns of administration, but there were divergent effects on inhibitory synapses and the subsequent balance between excitatory and inhibitory synaptic input. Overall, our data suggest that continuous morphine administration produces adaptations that dampen the output of D1-MSNs, which are canonically thought to promote reward-related behaviors. Interruption of otherwise continuous morphine exposure does not dampen D1-MSN functional output to the same extent, which may enhance behavioral responses to subsequent opioid exposure. Our findings support the hypothesis that maintaining continuity of opioid administration could be an effective therapeutic strategy to minimize the vulnerability to opioid use disorders.SIGNIFICANCE STATEMENTWithdrawal plays a key role in the cycle of addiction to opioids like morphine. We studied how repeated cycles of naloxone-precipitated withdrawal from otherwise continuous opioid exposure can change brain function of the nucleus accumbens, which is an important brain region for reward and addiction. Different patterns of opioid exposure caused unique changes in communication between neurons in the nucleus accumbens, and the nature of these changes depended on the type of neuron being studied. The specific changes in communication between neurons caused by repeated cycles of withdrawal may increase vulnerability to opioid use disorders. This highlights the importance of reducing or preventing the experience of withdrawal during opioid treatment.
Mechanical cervical ripening for prolonged pregnancies with a previous cesarean section: Double-balloon catheter vs Foley catheter
Authors: Martínez-Varea Alicia , Santolaria-Baig Andrea , Sánchez-Ajenjo Carlos , Monfort-Ortiz Rogelio , Perales-Marín Alfredo , Diago-Almela Vicente 
Published: November 2022

Introduction: Mechanical cervical ripening methods are considered safer than prostaglandins. Many centers choose this method for pre-induction in pregnant patients with a previous cesarean section. Our objective was to compare efficacy and safety of two different mechanical ripening methods in prolonged pregnancies with a Bishop score ≤ 6 and a previous cesarean section. Methods: Non-randomized study during 6 years in which patients were divided in two cohorts: a first period of time (from November 2014 to November 2018) in which Foley catheter was used and a second period of time (from November 2018 to November 2020) in which double-balloon catheter (Cook® balloon) was the method employed. The same protocol was followed in both groups. Efficacy was defined by the achievement of active labor. Ripening success (changes in Bishop score and achievement of active labor), vaginal delivery rate and maternal and neonatal safety were recorded. Results: The double-balloon was placed in 43 patients and the Foley catheter was inserted in 129 patients. Cook catheter showed better Bishop score difference than Foley but with no statistically significance (3.09 vs 2.76, p=0.271). Active labor was achieved similarly in both groups (81.4% double-balloon vs 78.2% Foley catheter, p=0.726). Although there was a higher vaginal delivery rate in the double-balloon group (62.8%) compared with the Foley group (49.6%), the difference was not statistically significant (p=0.065). Time from catheter insertion to delivery was significantly shorter in the Foley group compared with Cook group (1704 vs 1903 minutes, p<0.05). Newborn weight, umbilical-cord pH, Apgar index and maternal complications were similar in both groups. Conclusion: Mechanical cervical ripening is a safe and effective method in pregnancies with a previous cesarean section. Double-balloon ripening associated higher vaginal delivery rate compared to Foley catheter, but without statistically significant differences.