bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological and molecular identification of Callithrix sp. hybrids
Authors: Santos Bruna Mendonça , Aleixo Talita Roberto , Rodrigues Larissa Pereira , Nogueira Pedro Paulo Oliveira , Felippi Daniel Angelo , Mota Lígia Souza Lima Silveira da 
Published: December 2022

Abstract

The Common marmoset (Callithrix jacchus) and Black-tufted marmoset (Callithrix penicillata) are endemic species in the Northeast, East Central and part of the Northeast, respectively in Brazil. Currently, both species are distributed in different regions of the country, being the main cause the illegal trafficking. The introduction of exotic animals is the second biggest cause of biodiversity loss globally and can lead to hybridization. In Bauru, São Paulo (SP), there is a record of both species and animals showing intermediate patterns between them. Thus, this work aimed to identify individuals of the genus Callithrix present in The Municipal Botanical Garden of Bauru (MBGB) as either pure or hybrids, through morphological and molecular markers. Ten individuals were sampled, 4 of which were pure species for control and six free-living, which were photographed, morphometrically measured, and from which the fragments of the mitochondrial genes COI and D-loop region were amplified. As a result, all animals showed intermediate patterns between both species. After analyzing the sequences obtained for D-loop and obtaining a high haplotypic diversity (h), low nucleotide diversity (π), Tajima D and Fu’s Fs statistic, it is possible to infer that the animals in the area continue receiving gene flow and the population began from a founder effect. Morphological and molecular data indicate that the individuals sampled are hybrids. From the data generated by this research, it is possible to plan the insertion of management of these animals in the Conservation Unit (UC), to avoid population growth and its outcomes.
Post-Surgical Inflammatory Neuropathy after Anterior Cruciate Ligament Repair - A case report
Authors: Sun Lisa Y , Gray Andrew T , Braehler Matthias R 
Published: December 2022

Abstract
Background
Unanticipated symptoms of peripheral nerve damage following surgery are distressing to both the patient and their clinical team, including surgeons, anesthesiologists and neurologists. The causes that are commonly considered for perioperative neuropathy can include surgical trauma, positioning-related injury, or injury related to a regional anesthetic technique. However, these cases often do not have a clear etiology, and can occur without any apparent periprocedural anomalies. Postoperative inflammatory neuropathy is a more recently described, and potentially underrecognized cause of perioperative neuropathy which may improve with corticosteroid therapy. Therefore, it is an important etiology to consider early in the evaluation of a perioperative neuropathy.
Case Presentation
An otherwise healthy patient presented for left anterior cruciate ligament reconstruction. He underwent femoral and sciatic ultrasound-guided single injection peripheral nerve blocks preoperatively, followed by a general anesthetic for the surgical procedure. He developed postoperative neuropathy in the sciatic distribution with both sensory and motor deficits. The patient received multi-disciplinary consultations, including neurology and pain management, and a broad differential diagnosis was considered. Based on neurological evaluation and imaging studies, a final diagnosis of post-surgical inflammatory neuropathy was made. The patient’s course improved with conservative management, but immunosuppressive treatment may have been considered for a more severe or worsening clinical course.
Conclusions
There are limited publications describing postoperative inflammatory neuropathy, and this case serves to illustrate a potentially under-recognized and multifactorial cause of postoperative neuropathy. Perioperative neuropathies are a complication that surgeons and anesthesiologists strive to avoid, however prevention and treatment of this condition has been elusive. Increased reporting and investigation of postoperative inflammatory neuropathy as one cause for this complication will help to further our understanding of this potentially devastating complication.
Broadband metamaterial absorber based on magnetic composites
Authors: Zhu Zhenghou , Huang Wanqiao 
Published: December 2022

Abstract
The thickness and absorption width of electromagnetic wave absorbing materials remain a considerable challenge. This paper proposed a new design method for metamaterial absorbers. The absorber is composed of magnetic composites with a periodic structure. The effective absorption bandwidth(reflection loss<-10dB) achieves 13.4GHz, from 4.6GHz to 18GHz with 3.5mm thickness (0.05λmax). There are two absorption peaks at 6.1GHz and 10.8GHz, the reflection loss reaches − 20dB and − 15.6dB, respectively. The loss mechanism is analyzed by analyzing the electric field distribution and surface current. Actual samples were prepared, their reflection losses were measured, and the test results verified the simulation results.
Clinical-epidemiological profile of congenital and acquired heart diseases admitted to a Private Hospital
Authors: Foronda Gustavo , de Melo Vanessa Ferreira Amorim , Barbar Samia Medeiros , Fogarolli Renata , Tossuniam Carlos Eduardo , Arrieta Santiago Raúl 
Published: December 2022

Abstract
Objectives: To characterize the clinical-epidemiological profile of children with heart diseases (congenital, acquired and arrhythmias), conducted by the pediatric cardio group of a private general hospital, from January 2016 to March 2020.
Method: Retrospective longitudinal observational interference study, with quantitative design, carried out in a private hospital. A total of 502 patients were selected according to the following inclusion criteria: patients who had congenital heart disease, acquired heart disease and arrhythmia, all managed by the pediatric cardiomyopathy group. Descriptive analysis of absolute and relative frequencies were represented through tables and graphs.
Results: Of the 502 patients included in the study, 86.5% had congenital heart disease, 7.7% acquired heart disease and 5.8% arrhythmias. 50.2% were female, 49.6% male and 0.2% were not defined so far. Prematurity occurred in 19.3% of cases, presence of syndromes in 31.2 % and associated comorbidities in 34.7%. In total, 530 procedures were performed, of which 77% were surgeries, 18.5% hemodynamic procedures and 4.5% hybrid procedures. A risk score called RACHS-1 (adjusted risk for surgery and congenital heart disease) was used to categorize the surgeries. There was a predominance of category 3 (38.4%), followed by category 2 (28.6%), category 1 (18.2%), category 4 (9.6%) and category 6 (5.2%).
Conclusions: The complexity of the profile of the found heart diseases reiterates that measures are needed for an integrated approach of different specialties and professionals for the treatment of these patients.
Population Pharmacokinetic and Covariate Analysis of Anlotinib in Patients with Malignant Tumors
Authors: Xu Gaoqi , Yang Dihong , Shu Qi , Zhu Junfeng , Ding Haiying , Xin Wenxiu , Zhong Like , Zhu Liqin , Luo Fang 
Published: December 2022

Abstract
Purpose The objective of this study was to develop a population pharmacokinetic (popPK) model of anlotinib and to investigate the impact of various covariates in patients with malignant tumors.
Methods A total of 407 anlotinib plasma concentrations from 16 patients were analyzed in this study. Anlotinib was administered orally 12 or 16 mg in the single-dose phase and 12 mg once daily in the multiple-dose phase. PopPK model was established using nonlinear mixed-effects model (NONMEM) method. The potential influence of demographic and pathophysiological factors on oral anlotinib pharmacokinetic was investigated in a covariate analysis. The final model was evaluated using goodness-of-fit plots, visual predictive check, and bootstrap methods.
Results The pharmacokinetic profile of anlotinib was best described by a one-compartment model with first-order absorption and linear elimination. The population estimates of the apparent total clearance (CL/F), apparent volume of distribution (V/F) and absorption rate constant (Ka) were 8.91 L/h, 1950 L and 0.745 h-1, respectively. Body weight was identified as a significant covariate on V/F. Patients with low body weight tended to show higher exposure to anlotinib than those with high body weight. However, these differences were not clinically significant in the simulations of the individual body weight effects. No obvious bias was found in the final model by bootstrap and VPC methods.
Conclusion This popPK model adequately described the pharmacokinetics of anlotinib in patients with malignant tumors. Anlotinib does not need any dose modifications since the effect size for the individual covariate is not considered clinically relevant with anlotinib exposure.
Association of serum macrophage migration inhibitory factor with large hemisphere infarction and malignant cerebral edema after acute ischemic stroke
Authors: Guo Wen , Xu Mangmang , Song Xindi , Cheng Yajun , Deng Yilun , Liu Ming 
Published: December 2022

Abstract
Background：Macrophage migration inhibitory factor (MIF) is a crucial cytokine involved in inflammation after ischemic stroke, but little is known about its role in large hemisphere infarction (LHI) and malignant cerebral edema (MCE). We aimed to explore whether MIF and its related biomarkers (toll-like receptors [TLRs] and matrix metalloproteinase-9 [MMP-9]) were associated with LHI and MCE in patients with acute ischemic stroke (AIS).
Methods: We prospectively enrolled patients with AIS within 24 h from symptom onset. LHI was defined as cerebral infarction involving more than 1/3 of middle cerebral artery territory within 6 hours from onset or over 1/2 within 48 hours from onset. MCE was defined as a decreased level of consciousness, anisocoria and (or) midline shift over 5mm, basal cistern effacement, or an indication for decompressive craniectomy during hospitalization. Follow-up CTs within 7 days were needed for screening the presence of MCE. Logistic regression was performed to analyze the association of the above inflammatory biomarkers with LHI and MCE.
Results: Our present study included 263 patients (median age: 72 years; male: 50.6%), and 49.4% (130/263) developed LHI (median time from onset to LHI: 3h). Compared with patients without LHI, patients with LHI had a higher median serum level of MIF (median time from onset to blood collection: 3h; 9.51 vs. 7.26 ng/ml, p=0.036) and MMP-9 (36.77 vs. 29.88 ng/ml, p<0.001). MIF over 7.94 ng/ml (adjusted odds ratio [adOR] 1.836, 95% CI 0.988-3.415, p=0.055) and MMP-9 over 34.91ng/ml (adOR 3.283, 95% CI 1.722-6.258, p<0.001) were associated with an increased risk of LHI, separately. Fifty-five patients developed MCE, and the median time from onset to MCE was 32.06 h. Compared with patients without MCE, patients with MCE had a higher level of MIF (9.41 vs. 8.30 ng/ml, p=0.516) and MMP-9 (36.18 vs. 32.35 ng/ml, p=0.006), although the difference was not statistically significant for the former. After adjusted for confounders, neither MIF nor MMP-9 level was significantly associated with the risk of MCE. We did not find any independent association of TLR2/4 with either LHI or MCE.
Conclusions: This study indicated that higher levels of MIF and MMP-9 were related to LHI. There were trends of association between a higher level of serum MIF/MMP-9 and an increased risk of MCE after AIS, which was warranted further validation in future larger studies.
Non-ischaemic fibrosis in male veteran endurance athletes: mechanisms and association with premature ventricular beats
Authors: Farooq Maryum , Brown Louise AE , Fitzpatrick Andrew , Broadbent David A , Wahab Ali , Klassen Joel , Farley Jonathan , Saunderson Christopher ED , Das Arka , Craven Thomas , Dall’Armellina Erica , Levelt Eylem , Xue Hui , Kellman Peter , Greenwood John P , Plein Sven , Swoboda Peter P 
Published: December 2022

Abstract
Purpose
Left ventricular fibrosis can be identified by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) in some veteran athletes. We aimed to investigate prevalence of ventricular fibrosis in veteran athletes and its association with cardiac arrhythmia.
Methods
Fifty asymptomatic male endurance athletes (inclusion criteria: age ≥50, >10 hours/week training for >15 years) and 26 matched controls were recruited. They underwent CMR imaging including volumetric analysis, bright blood (BB) and dark blood (DB) LGE, motion corrected (MOCO) quantitative stress and rest perfusion and T1/T2/extracellular volume mapping. Athletes underwent 12-lead electrocardiogram (ECG) and 24-hour ECG.
Results
Myocardial fibrosis was identified in 24/50 (48%) athletes. All fibrosis was mid-myocardial in the basal-lateral wall of the left ventricle. Blood pressure was reduced in athletes without fibrosis compared to controls, a trend not seen in athletes with fibrosis. Fibrotic areas compared to healthy myocardium had longer T2 time (44±4 vs 40±2ms, p<0.0001), lower rest myocardial blood flow (MBF, 0.5±0.1 vs 0.6± 0.1ml/g/min, p<0.0001) but no difference in stress MBF. On 24-hour ECG monitoring, athletes with fibrosis had a greater burden of premature ventricular beats (0.3±0.6 vs 0.05±0.2%, p=0.03), with higher prevalence of ventricular couplets and triplets (33 vs 8%, p=0.02).
Conclusion
In veteran endurance athletes, myocardial fibrosis is a common finding. Possible mechanisms for fibrosis include inflammation and blood pressure. Presence of myocardial fibrosis is associated with an increased burden of ventricular ectopy. Further studies are needed to establish whether fibrosis increases risk of malignant arrhythmic events.
AN ISLAMIC PERSPECTIVES, THE CURRENT STATE OF INDONESIA IN THE GLOBALIZATION ERA
Authors: Mas'ud Riduan , El-badriati Baiq , Azizurrohman Muhammad 
Published: December 2022

Abstract: Countries must be able to compete due to the high global intensity of trade and agreements. As a first step in dealing with this, many countries employ economic concepts that are tailored to their specific circumstances. The goal of this research is to look at the role of Islamic economics in dealing with the onslaught of economic globalization, such as China's Belt Road Initiative (BRI), and multi-sectoral institutions like the IMF and the World Bank. The literature research approach used in this paper is qualitative using literature review method. The results of this study found that the Indonesian government was in the midst of a powerful wave that required strong captains and ships. In other words, the existence of BRI, IMF and World Bank will be a threat if they are not controlled properly. As a result, the government has to divert this funding to productive areas such as agriculture. Furthermore, given China's concentration on Islamic banking, Indonesia may be able to persuade China to involve the Indonesian people in developing its products. Furthermore, the Indonesian government must be able to read every step taken by BRI, IMF, and World Bank so as not to be trapped in debt investment.
Keywords: Islamic economic, belt road initiative, IMF, worldbank
KINERJA PAJAK DAERAH KABUPATEN TULUNGAGUNG DITINJAU DARI ANALISIS RASIO EFEKTIVITAS DAN EFISIENSI PAJAK SERTA PERSPEKTIF EKONOMI ISLAM
Authors: Hapsari Mega Tunjung 
Published: December 2022

Abstrak: Tujuan penelitian adalah untuk mengukur kinerja pajak daerah Kabupten Tulungagung melalui analisa rasio efektivitas dan efisiensi pajak, serta menganalisa kinerja pajak ditinjau dari perspektif ekonomi Islam. Dengan menggunakan pendekatan kuantitatif deskriptif, melalui data sekunder yang bersumber laporan kinerja keuangan daerah Kabupaten Tulungagung tahun 2016-2020, dapat diketahui bahwa hasil analisa rasio pajak daerah bernilai sangat efektif dengan rata-rata 110,27% dan sangat efisien dengan rata-rata 4,55%. Sedangkan hasil dari analisa perspektif ekonomi Islam, pengelolaan pajak di Kabupaten Tulungagung telah memenuhi indikator profesional (jujur, adil, amanah), transparansi, dan akuntabilitas.
Kata kunci: keuangan daerah, pajak daerah, ekonomi Islam.

Abstract: The purpose of this research is to measure the local tax performance of Tulungagung Regency through the analysis of the ratio of effectiveness and efficiency of taxes, as well as to analyze the performance of taxes from the perspective of Islamic economics. By using a descriptive quantitative approach, through secondary data sourced from the 2016-2020 regional financial performance report of Tulungagung Regency, it can be seen that the results of the regional tax ratio analysis are very effective with an average of 110.27% and very efficient with an average of 4, 55%. While the results from the analysis of the Islamic economic perspective, tax management in Tulungagung Regency has met the professional indicators (honest, fair, trustworthy), transparency, and accountability.
Keywords: Regional Finance, Local Tax, Islamic Economy.
PENGARUH MANAJEMEN PENGELOLAAN KELAS TERHADAP KREATIVITAS SISWA
Authors: Rohmah Jazilatur 
Published: December 2022

Pendidikan yang berkualitas menjadi kebutuhan dan harapan masyarakat di era milenial agar mampu mempersiapkan sumber daya manusia yang unggul. Sebagai upaya pemenuhan atas kebutuhan ini sekolah perlu menyiapkan kurikulum, tenaga pengajar dan fasilitas yang memadai. Salah satu faktor yang memiliki peranan penting dalam proses pembelajaran adalah menejemen kelas. Manajemen kelas oleh guru merupakan faktor eksternal yang mampu menciptakan pembelajaran yang kondusif dan efektif. Penelitian ini dirancang untuk mengetahui secara mendalam pengaruh dari manajemen kelas terhadap motivasi belajar dan kreativitas siswa. Untuk mendapatkan hasil yang valid dan mendalam maka penelitian didesain dengan menggunakan pendekatan skuensial eksplanatori. Hasil dari penelitian ini menunjukkanÂ bahwa manajamen kelas berpengaruh secara signifikan positif terhadap motivasi belajar dan kreativitas siswa. Hal ini menunjukkan bahwa semakin baik manajemen kelas oleh guru, maka semakin baik pula motivasi belajar dan kreativitas yang dimiliki siswa. Ada beberapa hal yang dilakukan guru untuk dalam memanajemen kelas diantaranya yaitu dengan menata kelas dengan rapi, mendekorasi kelas bersama siswa, menjaga kebersihan ruang kelas, menerapkan pola komunikasi yang terbuka dengan siswa, mendesain pembelajaran yang aktif dan menyenangkan serta melibatkan siswa dalam pengambilan keputusan di kelas.
THE PARADIGM OF MULTICULTURAL EDUCATION THROUGH DEVELOPMENT OF UNITY IN DIVERSITY
Authors: Suprihno Suprihno 
Published: December 2022

Abstract: This article isÂ analysingÂ the paradigm ofÂ MulticulturalÂ Education trough development of character unity in diversity.Â MulticulturalÂ education is an alternativeÂ to solve theÂ problem ofÂ the diversity in Indonesia. DiversityÂ in negative meaning hasÂ spawnedÂ sufferingÂ long time for human beings. AtÂ thisÂ time, at leastÂ thereÂ haveÂ beenÂ 35Â majorÂ conflictsÂ betweenÂ ethnic groups in the world. MoreÂ thanÂ 38Â millionÂ inhabitantsÂ driven outÂ ofÂ the placeÂ thatÂ theyÂ live, at least a bit ofÂ 7Â millionÂ peopleÂ has been killedÂ in theÂ conflictÂ ethnicÂ bloody.Â A long Conflict involves sentiments of ethnic,Â racial,Â classÂ and religion. This article using library research method. Sources of data used by researchers in accordance with the type of research that is literary or library research (library research) then in the form of literature from books, documents, journals or scientific papers. NationÂ IndonesiaÂ is needed of unity,Â thingsÂ haveÂ to beÂ formedÂ ifÂ doneÂ byÂ the principle ofÂ unity in diversity. ToÂ foster aÂ tradition ofÂ unity in diversity,Â multiculturalÂ education isÂ needed. Multicultural educationÂ is aÂ bridgeÂ toÂ usher inÂ aÂ newÂ generationÂ ofÂ openÂ faces ofÂ difference, the development of aÂ nation'sÂ cultureÂ that isÂ farthestÂ fromÂ prejudice,Â conflictÂ andÂ violence. Eliminating sectarianÂ viewsÂ andÂ exclusivity. AndÂ willÂ openÂ the viewÂ inclusivity open to cooperation withÂ other people,Â despiteÂ havingÂ beliefs,Â opinions,Â identityÂ andÂ different styleÂ of life. OneÂ of theÂ forms ofÂ problem solving is transforming theÂ program called â€œservice learningâ€. There isÂ aÂ methodÂ of learning. In whichÂ studentsÂ learnÂ andÂ developÂ their competenceÂ byÂ way of actively participatingÂ inÂ the practice ofÂ the serviceÂ of societyÂ isÂ organized. Keyword:Â Education,Â Multicultural, unity in diversity, Service-learning
Pengembangan tes kebugaran jasmani untuk anak tunanetra menggunakan modifikasi harvard step test tingkat sekolah dasar
Authors: Septiasari Erda Ayu , Sumaryanti Sumaryanti 
Published: December 2022

Penelitian ini bertujuan untuk menghasilkan sebuah tes kebugaran jasmani berupa bangku modifikasi Harvard step test yang sesuai dengan karakteristik anak tunanetra tingkat Sekolah Dasar (SD). Penelitian ini menggunakan research and development. Validasi ahli dilakukan oleh tiga pakar yaitu: pakar pendidikan adaptif, pakar tes pengukuran dan pakar konstruksi bangku. Ujicoba lapangan dilakukan terhadap dua sekolah SLB yang ada di DIY. Ujicoba skala kecil dilakukan pada empat siswa tunanetra SLB N 1 Bantul. Ujicoba skala besar dilakukan pada sepuluh siswa SLB A Yaketunis. Uji validitas dan reliabilitas menggunakan validitas empirik dan reliabilitas test-retest yang dilakukan pada tujuh siswa SLB A Yaketunis. Penelitian ini menghasilkan alat tes kebugaran jasmani berupa modifikasi Harvard step test yang dibuat berdasarkan karakteristik anak tunanetra yang memiliki validitas dan reliabilitas baik, sehingga dapat dijadikan alat ukur yang digunakan guru untuk mengevaluasi tingkat kebugaran siswa tunanetra di sekolah. Developing a physical fitness test for blind children using the modified Harvard step test for elementary school Abstract: This study aims to develop a physical fitness test in the form of a modified Harvard step test bench in accordance with the characteristics of blind children, for blind children at the elementary level. This development was modified in two stages: the preliminary stage and the development stage. The research trials were conducted in two schools of SLB in DIY. The small-scale trials were conducted on four students of SLB N 1 Bantul. A large trial was conducted on ten students of SLB A Yaketunis. The validity and reliability were measured using empirical validity and test-retest reliability. The study concludes that the modification of the Harvard step test made based on the characteristics of blind children has good validity and reliability, and so it can be used as a measuring tool used by teachers to evaluate the fitness level of blind children in school.