bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is the best anthropometry index to evaluate the risk of metabolic abnormalities in Chinese adults?
Authors: Hu Jun , Jiang Yongbin , Shen Hui , Ding Limin , Xu Xiaopao , Wu Wenjun 
Published: October 2022

AbstractAimsObesity, defined by body mass index (BMI), is a heterogeneous condition with varying metabolic manifestations, and the best index for predicting metabolic abnormalities remains unclear. This study aimed to explore the most suitable anthropometry index for predicting metabolic abnormalities in Chinese adults.MethodsA cross‐sectional study was conducted using the data obtained from 9517 Chinese adults who underwent physical examination, bioelectrical impedance analysis, and laboratory examinations between March 2018 and March 2022. Participants were further divided into eight subgroups according to age, BMI, and sex. Descriptive statistics were calculated, and the area under the receiver operating characteristic curve and Youden index values were calculated to identify the best predictor of metabolic abnormalities in Chinese adults.ResultsThe waist‐to‐height ratio (WHtR) had the largest area under the curve for predicting metabolic abnormalities in men of any age and women aged 18–49 years. However, BMI showed the highest accuracy in predicting metabolic abnormalities in women aged 50 years and older. Based on the highest Youden index, the optimal WHtR threshold was 0.51 in women and 0.53 in men.ConclusionsThe WHtR was the most effective index for predicting metabolic abnormalities in most Chinese adults, whereas BMI showed a higher accuracy only in elderly women. This observation supports WHtR as a novel adiposity marker for screening metabolic abnormalities and shows value for public health practice.
Annual variation in breeding success in boreal forest grouse: Four decades of monitoring reveals bottom‐up drivers to be more important than predation
Authors: Wegge Per , Moss Robert , Rolstad Jørund 
Published: October 2022

AbstractKnowledge of the temporal variation in reproductive success and its key driving factors is crucial in predicting animal population persistence. Few studies have examined the effects of a range of explanatory factors operating simultaneously on the same population over a long period. Based on 41 years of monitoring (1979–2019), we tested prevailing hypotheses about drivers of annual variation in breeding success in two sympatric species of boreal forest grouse—the capercaillie (Tetrao urogallus) and the black grouse (T. tetrix)—in a 45 km2 boreal forest landscape. From counts in early August, we measured breeding success (chicks/hen) along with potential determining factors. We formulated five main hypotheses on causes of variation (hen condition, chick weather, chick food, predation, demographic characteristics) and derived 13 associated explanatory variables for analysis. We first tested the five hypotheses separately and then used model selection (AICc) to rank the best predictive models irrespective of hypotheses. Lastly, we used path analysis to illuminate potential causal relationships. Barring demographic characteristics, all hypotheses were supported, most strongly for chick food and predation. Among predictor variables, chick food (insect larvae and bilberry fruit crops), vole and fox abundances, the winter‐NAO index, and temperature after hatching, had the strongest effect sizes in both species. Precipitation after hatching had no detectable effect. Model selection indicated bottom‐up factors to be more important than predation, but confounding complicated interpretation. Path analysis suggested that the high explanatory power of bilberry fruiting was due not only to its direct positive effect on chick food quality but also to an indirect positive effect on vole abundance, which buffers predation. The two components of breeding success—proportion of hens with broods and number of chicks per brood—were uncorrelated, the former having the strongest effect. The two components had different ecological correlates that often varied asynchronously, resulting in overall breeding success fluctuating around low to moderate levels. Our study highlights the complexity of key explanatory drivers and the importance of considering multiple hypotheses of breeding success. Although chick food appeared to equal or surpass predation in explaining the annual variation in breeding success, predation may still be the overall limiting factor. Comparative and experimental studies of confounded variables (bilberry fruiting, voles, and larvae) are needed to disentangle causes of variation in breeding success of boreal forest grouse.
Functional traits of riparian trees in the lower Fitzroy River, Western Australia
Authors: Canham Caroline A. , Woods Calum , Setterfield Samantha A. , Veneklaas Erik J. , Freestone Fiona L. , Beesley Leah S. , Douglas Michael M. 
Published: October 2022

AbstractRiparian trees are critically important for maintaining the ecological function of freshwater ecosystems. Globally, anthropogenic changes to water regimes are impacting the health and distribution of riparian trees. Understanding the physiological constraints on the distribution of riparian tree species in relation to the water regime is essential for informed water resource management that seeks to limit impacts on riparian trees. To fill an identified knowledge gap for the Fitzroy River, a significant river in the wet–dry tropics of north‐western Australia, we used a trait‐based approach to characterise nine common riparian tree species in relation to their distribution along a hydrological gradient. We assessed key functional traits related to drought and flood flows. Leaf mass per unit area (LMA), leaf dry matter content (LDMC), foliar carbon content (% C) and the ratio of carbon to nitrogen (C:N) are broadly related to plant productivity and durability and may reflect resistance to fluvial stress. Traits related to water availability were stem specific density (SSD), mean xylem vessel diameter and xylem vessel density, as well as foliar δ13C which is related to water use efficiency, and leaf osmotic potential at full hydration (π100) as a measure of drought tolerance. We found that π100, δ13C and SSD values reflected species hydrological habitat preferences, with higher δ13C values and lower π100 for species distributed in the drier floodplain habitats, compared with species constrained to the riverbank. Low SSD values for species close to the riverbank may be indicative of aerenchyma tissue in response to flooding. Differences in leaf trait values were primarily attributed to differences between evergreen Myrtaceous and deciduous non‐Myrtaceous species, rather than hydrological habitat preferences. LMA was greatest for the Myrtaceous study species, with deciduous non‐Myrtaceous species associated with wetter habitats having the lowest values. The physiology of riparian trees in northern Australia is not well described for the majority of species. Our study provides insight into plant functional strategies in response to both flooding and drought and is a critical step in understanding plant responses to future water‐take scenarios to support evidence‐based decision making.
Protesting for stability or change? Definitional and conceptual issues in the study of reactionary, conservative, and progressive collective actions
Authors: Thomas Emma F. , Osborne Danny 
Published: October 2022

AbstractOver the last quarter of a century, social psychological research on collective action has grown exponentially and progressed through four distinct phases. While the first phase showed that identity, efficacy, and injustice motivate the aggrieved to protest on behalf of their ingroup, the second phase acknowledged that protests could involve collaborations between the disadvantaged and their advantaged allies. The third phase of research examined reactionary movements by integrating ideology and acknowledging that advantaged groups can protest to protect or expand their privileged status. The research showcased in this special issue highlights a fourth phase of collective action by illustrating its dialectical nature and recognising the opposing agendas advanced by structurally disadvantaged and advantaged groups. We also advance a two‐dimensional taxonomy differentiating between the goals (Inclusive vs. Exclusive) and societal implications (Challenge vs. Defend the Status Quo) of collective action. In doing so, we provide some of the necessary conceptual and definitional foundations for the next generation of research on collective action and social change.
Morphology, flow dynamics and evolution of englacial conduits in cold ice
Authors: Kamintzis Jayne E. , Irvine‐Fynn Tristram D. L. , Holt Tom O. , Jones John P. P. , Porter Philip R. , Jennings Stephen J. A. , Naegeli Kathrin , Hubbard Bryn 
Published: October 2022

AbstractMeltwater routing through ice masses exerts a fundamental control over glacier dynamics and mass balance, and proglacial hydrology. However, despite recent advances in mapping drainage systems in cold, Arctic glaciers, direct observations of englacial channels and their flow conditions remain sparse. Here, using terrestrial laser scanning (TLS) surveys of the main englacial channel of cold‐based Austre Brøggerbreen (Svalbard), we map and compare an entrance moulin reach (122 m long) and exit portal reach (273 m long). Analysis of channel planforms, longitudinal profiles, cross‐sections and morphological features reveals evidence of spatial variations in water flow conditions and channel incision mechanisms, and the presence of vadose, epiphreatic and phreatic conditions. The entrance reach, located at the base of a perennial moulin, was characterized by vadose, uniform, channel lowering at annual timescales, evidenced by longitudinal grooves, whereas the exit portal reach showed both epiphreatic and vadose conditions, along with upstream knickpoint migration at intra‐annual timescales. Fine‐scale features, including grooves and scallops, were readily quantified from the TLS point cloud, highlighting the capacity of the technique to inform palaeoflow conditions, and reveal how pulses of meltwater from rainfall events may adjust englacial conduit behaviour. With forecasts of increasing Arctic precipitation in the coming decades, and a progressively greater proportion of glaciers comprising cold ice, augmenting the current knowledge of englacial channel morphology is essential to constrain future glacier hydrological system change.
Numerical analysis of heat transfer and magnetohydrodynamic flow of viscoelastic Jeffery fluid during forward roll coating process
Authors: Ali Fateh , Hou Yanren , Zahid Muhammad , Rana M. A. , Kumam Poom , Sitthithakerngkiet Kanokwan 
Published: October 2022

AbstractThe steady‐state laminar nonisothermal, incompressible viscoelastic fluid flows with the Jeffrey model between two counterrotating (same direction) rolls are studied analytically. The Jeffrey model is reduced to the Newtonian model after some appropriate modifications. The new dimensionless governing equations are acquired through suitable nondimensional values. The lubrication approximation theory is employed for the simplification of emerging equations. The exact expressions for pressure gradient, velocity, temperature, and flow rate are accomplished whereas some quantities of interest such as pressure, coating thickness, power transmitted by rolls to the fluid, and roll separation force are computed numerically by using a numerical method. The influence of emerging parameters such as the ratio of relaxation time to the retardation time , magnetohydrodynamic (MHD) parameter and Brinkman number on velocity profile, temperature profile, pressure gradient, pressure distribution, coating thickness, power input, and force of roll separation are presented numerically in a tabular way and specific outcomes are demonstrated graphically. The MHD acts as a regulatory parameter for various quantities of important interest, such as velocity, coating thickness, and temperature. It is worth noting that the coating thickness decreases as modified capillaries number is increased.
Making colonoscopy‐based screening more efficient: A “gateopener” approach
Authors: Heisser Thomas , Cardoso Rafael , Niedermaier Tobias , Hoffmeister Michael , Brenner Hermann 
Published: October 2022

AbstractScreening colonoscopy for early detection and prevention of colorectal cancer (CRC) is mostly used inefficiently. Here, we assessed the potential of an innovative approach to colonoscopy‐based screening, by use of a single, low threshold fecal immunochemical test (FIT) as a “gateopener” for screening colonoscopy. Using COSIMO, a validated simulation model, we modeled scenarios including either direct invitation to screening colonoscopy or an alternative approach involving mailing a single (“gateopener”) FIT along with an invitation to colonoscopy contingent on a FIT value above a low threshold yielding a 50% positivity rate (ie, every other pretest will be positive). Under plausible assumptions on screening offer adherence, we found that such “gateopener screening” (use of screening colonoscopy contingent on a positive, low threshold gateopener FIT) approximately doubled cancer detection rates vs conventional screening. In those spared from screening colonoscopy due to a negative gateopener FIT pretest, numbers needed to screen were 10‐times higher vs those for individuals with a positive FIT, peaking in >2000 and >3800 (hypothetically) needed colonoscopies to detect one case of cancer in men and women, respectively. Gateopener screening resulted in 42%‐51% and 59%‐65% more prevented CRC cases and deaths, respectively. In summary, by directing colonoscopy capacities to those most likely to benefit, offering screening colonoscopy contingent on a “gateopener” low‐threshold FIT would substantially enhance efficiency of colonoscopy screening.
A Vision for Universal and Standardized Access to Systems Competency Education
Authors: Singam Caitlyn A. K. 
Published: October 2022

ABSTRACTThe interdisciplinary nature of systems engineering inherently means that the concept of a systems engineer is variable, requiring several types of expertise depending on the application sector and knowledge domain the individual is working in. However, regardless of industry or specialty, systems engineers are all unified by proficiency in a core set of fundamental competencies that allow them to understand and holistically work with systems.These systems thinking and systems engineering competencies are applicable by being interdisciplinary and are well‐suited to an increasingly globalized and interconnected world. However, views of systems thinking and systems engineering competencies as non‐essential supplementary skills rather than foundational ones have meant that systems thinking and systems engineering concepts are not generally included in science, technology, engineering, arts, and mathematics (STEAM) curricula until late in the educational pathway and are not always presented in a standardized manner. Consequently, under the current approach to systems thinking and systems engineering, not all individuals who can benefit from systems thinking and systems engineering education have access to it. Those who do often face substantial variability in the quality of their educational experiences.This article discusses existing issues relating to systems thinking and systems engineering competency education, as well as the efforts of the INCOSE SySTEAM Initiative towards addressing those issues and facilitating the integration of systems thinking and systems engineering competencies into STEAM curricula at all levels of education. Furthermore, this article presents a guiding philosophy for promoting universal and standardized access to systems competency education.
Probing the effects of matrix‐derived microcarrier composition on human adipose‐derived stromal cells cultured dynamically within spinner flask bioreactors
Authors: Kornmuller Anna , Cooper Tyler T. , Jani Ammi , Lajoie Gilles A. , Flynn Lauren E. 
Published: October 2022

AbstractRecognizing the cell‐instructive capacity of the extracellular matrix (ECM), this study investigated the effects of expanding human adipose‐derived stromal cells (hASCs) on ECM‐derived microcarriers fabricated from decellularized adipose tissue (DAT) or decellularized cartilage tissue (DCT) within spinner flask bioreactors. Protocols were established for decellularizing porcine auricular cartilage and electrospraying methods were used to generate microcarriers comprised exclusively of DAT or DCT, which were compositionally distinct, but had matching Young's moduli. Both microcarrier types supported hASC attachment and growth over 14 days within a low‐shear spinner culture system, with a significantly higher cell density observed on the DCT microcarriers at 7 and 14 days. Irrespective of the ECM source, dynamic culture on the microcarriers altered the expression of genes and proteins associated with cell adhesion and ECM remodeling. Label‐free mass spectrometry analysis showed upregulation of proteins associated with cartilage development and ECM in the hASCs expanded on the DCT microcarriers. Based on Luminex analysis, the hASCs expanded on the DCT microcarriers secreted significantly higher levels of IL‐8 and PDGFAA, supporting that the ECM source can modulate hASC paracrine factor secretion. Finally, the hASCs expanded on the microcarriers were extracted for analysis of adipogenic and chondrogenic differentiation relative to baseline controls. The microcarrier‐cultured hASCs showed enhanced intracellular lipid accumulation at 7 days post‐induction of adipogenic differentiation. In the chondrogenic studies, a low level of differentiation was observed in all groups. Future studies are warranted using alternative cell sources with greater chondrogenic potential to further assess the chondro‐inductive properties of the DCT microcarriers.
Stochastic kinetic study of protein aggregation and molecular crowding effects of Aβ40 and Aβ42
Authors: Bridstrup John , Yuan Jian‐Min , Schreck John S. 
Published: October 2022

AbstractTwo isoforms of β‐amyloid peptides, Aβ40 and Aβ42, differ from each other only in the last two amino acids, IA, at the end of Aβ42. They, however, differ significantly in their ability in inducing Alzheimer's disease (AD). The rate curves of fibril growth of Aβ40 and Aβ42 and the effects of molecular crowding have been measured in in vitro experiments. These experimental curves, on the other hand, have been fitted in terms of rate constants for elementary reaction steps using rate equation approaches. Several sets of such rate parameters have been reported in the literature. Employing a recently developed stochastic kinetic method, implemented in a browser‐based simulator, popsim, we study to reveal the differences in the kinetic behaviors implied by these sets of rate parameters. In particular, the stochastic method is used to distinguish the kinetic behaviors between Aβ40 and Aβ42 isoforms. As a result, we make general comments on the usefulness of these sets of rate parameters.
Young geniuses versus old masters: Two different trajectories of individual knowledge bases in the innovation process
Authors: Zhu Siwei , Morkan Baris , Yan Zhipeng 
Published: October 2022

AbstractKnowledge depth and knowledge breadth, the two dimensions of individual knowledge bases, are the most fundamental sources of innovation. Following a mixed‐method approach, we collect data from top chemical scientists in the R&D department of a leading US oil and gas company and investigate how individuals leverage their knowledge bases in the innovation process. In the qualitative study, we develop a conceptual framework with the two‐stage innovation process and label two distinct groups of individuals as “Young Geniuses” with high knowledge depth and “Old Masters” with high knowledge breadth. In the quantitative study, our analysis shows two different trajectories toward the innovation process: the negative impact of knowledge depth on early stage knowledge combinations for Young Geniuses occurs extremely early; the diminishing return of knowledge breadth on late‐stage commercialization for Old Masters occurs very late. Our study further analyzes the interaction effect of knowledge breadth for knowledge depth and provides practical implications for managers; in particular, inventors who better comprehend the timing of switching knowledge development can navigate the innovation process to achieve fruitful outcomes.
Publicly available framework for simulating and experimentally validating clinical PET systems
Authors: O'Briain Teaghan B. , Uribe Carlos , Sechopoulos Ioannis , Michel Christian , Bazalova‐Carter Magdalena 
Published: October 2022

AbstractBackground: Monte Carlo (MC) simulations are a powerful tool to model medical imaging systems. However, before simulations can be considered the ground truth, they have to be validated with experiments.Purpose: To provide a pipeline that models a clinical positron emission tomography (PET)/CT system using MC simulations after extensively validating the results against experimental measurements.Methods: A clinical four‐ring PET imaging system was modeled using Geant4 application for tomographic emission (v. 9.0). To validate the simulations, PET images were acquired of a cylindrical phantom, point source, and image quality phantom with the modeled system and the simulations of the experimental procedures. For the purpose of validating the quantification capabilities and image quality provided by the simulation pipeline, the simulations were compared against the measurements in terms of their count rates and sensitivity as well as their image uniformity, resolution, recovery coefficients (RCs), coefficients of variation, contrast, and background variability.Results: When compared to the measured data, the number of true detections in the MC simulations was within 5%. The scatter fraction was found to be 30.0% ± 2.2% and 28.8% ± 1.7% in the measured and simulated scans, respectively. Analyzing the measured and simulated sinograms, the sensitivities were found to be 8.2 and 7.8 cps/kBq, respectively. The fraction of random coincidences were 19% in the measured data and 25% in the simulation. When calculating the image uniformity within the axial slices, the measured image exhibited a uniformity of 0.015 ± 0.005, whereas the simulated image had a uniformity of 0.029 ± 0.011. In the axial direction, the uniformity was measured to be 0.024 ± 0.006 and 0.040 ± 0.015 for the measured and simulated data, respectively. Comparing the image resolution, an average percentage difference of 2.9% was found between the measurements and simulations. The RCs calculated in both the measured and simulated images were found to be within the EARL ranges, except for that of the simulation of the smallest sphere. The coefficients of variation for the measured and simulated images were found to be 12% and 13%, respectively. Lastly, the background variability was consistent between the measurements and simulations, whereas the average percentage difference in the sphere contrasts was found to be 8.8%.Conclusion: The clinical PET/CT system was modeled and validated to provide a simulation pipeline for the community. The pipeline and the validation procedures have been made available (https://github.com/teaghan/PET_MonteCarlo).