bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe SARS‐CoV‐2 infection in a 32‐week pregnant woman treated with Remdesivir‐Dexamethasone combination therapy: A case report
Authors: Alavi Seyed Mohammad Amin , Bahrami Samaneh , Najafian Mahin , Hoori Mina 
Published: August 2022

AbstractThis study shows that remdesivir and dexamethasone combination therapy can be considered as a suitable treatment choice for pregnant women infected with COVID‐19. It is worth mentioning that more studies are required to evaluate the efficacy and side effects of remdesivir monotherapy and its combination with dexamethasone during pregnancy.
Ligand‐to‐Metal Charge Transfer (LMCT) Photochemistry at 3d‐Metal Complexes: An Emerging Tool for Sustainable Organic Synthesis
Authors: Juliá Fabio 
Published: August 2022

AbstractDespite the rich photochemistry of 3d‐metal complexes, the utilization of excited‐state reactivity of these compounds in organic synthesis has been historically overlooked. The advent of photoredox catalysis has changed the perception of synthetic chemists towards photochemistry, and nowadays the potential of photoinduced, outer‐sphere single‐electron transfer events is widely recognized. More recently, an emerging new mode of photoactivation has taken the spotlight, based on an inner‐sphere mode of reactivity triggered by population of ligand‐to‐metal charge‐transfer (LMCT) excited states. Contrarily to photoredox, LMCT‐activation does not rely on matching redox potentials, offers unique reactivity profiles and is particularly well suited on Earth‐abundant metal complexes. Those appealing features are propelling the development of methods using this blueprint to generate highly reactive open‐shell species under mild conditions. The aim of this contribution is to provide a didactical tool for the comprehension of this emerging concept and facilitate the development of new synthetic methodologies to achieve sustainable chemical transformations.
Protein Conjugation Helped CdTe Quantum Dots for the Specific Labeling and Super‐Resolution Imaging of Lysosomes
Authors: Kaushik Kush , Yadav Aditya , Anjum Farhan , Mani Mishra Pushpendra , Sharma Shagun , Rao Chethana , Kanti Nandi Chayan 
Published: August 2022

AbstractSemiconductor quantum dots possess many attractive features such as high quantum yield, and narrow emission, and offer great advantages over organic dyes. However, the fluorescence intermittency and the cytotoxicity limit their biological applications. In this communication, we show a substantial increase in cell viability and the tuning of intermittency of water‐soluble CdTe quantum dots upon conjugation with bovine serum albumin (BSA), which helped them for their use as fluorescent probe for super resolution bioimaging of lysosomes. The quantum dots were not only found to be highly specific to stain the lysosome but also provided the super‐resolution image's resolution down to ∼60 nm, which is close to the smallest size of the lysosome. Photons per cycle were found to play a significant role in improving localization precision and thus improved the quality of the super resolution images.
A new feature selection method based on frequent and associated itemsets for text classification
Authors: Mamdouh Farghaly Heba , Abd El‐Hafeez Tarek 
Published: August 2022

SummaryFeature selection is one of the major issues in pattern recognition. The quality of selected features is important for classification as the low‐quality data can degrade the model construction performance. Due to the difficulty of dealing with the problem that selected features always contain redundant information, this article focuses on the association analysis theory in data mining to select important features. In this study, a novel feature selection method based on frequent and associated itemsets (FS‐FAI) for text classification is proposed. FS‐FAI seeks to find relevant features and also takes feature interaction into account. Moreover, it uses association as a metric to evaluate the relativity between the target concept and feature(s). To evaluate the efficacy of the proposed method, several experiments were conducted on a BBC dataset from the BBC news website and SMS spam collection dataset from the UCI machine learning repository. The obtained results were compared to well‐known feature selection methods. The reported results demonstrated the effectiveness of the proposed feature selection method in selecting high‐quality features and in handling redundant information in text classification.
Robust ratio‐type estimators for finite population mean in simple random sampling: A simulation study
Authors: Zaman Tolga , Bulut Hasan , Yadav Subhash Kumar 
Published: August 2022

SummaryIn this study, ratio estimators are proposed by utilizing some robust techniques to get the maximum benefit of the auxiliary variable for the estimation of the population mean in simple random sampling. The expressions for mean squared error are derived for the first degree of approximation. Theoretical comparisons demonstrate that the suggested estimators having robust regression estimates perform better than the existing estimators under certain conditions. Theoretical findings are supported with the aid of the original dataset in an application. In addition, a simulation study is also conducted to evaluate the performance of the suggested estimators.
Noise processing and multitask learning for far‐field dialect classification
Authors: Wang Hai , Wang Yan , Ma Yuhui , Qin Chenguang , Zhang Kan , Gao Ling , Ren Jie 
Published: August 2022

SummaryDeep learning has made great achievements in the field of speech recognition. With the popularization of embedded devices such as intelligent speaker and the demand for dialect interaction scenes, it poses great challenges to far‐field speech recognition and dialect language recognition. In order to solve the dialect language recognition of embedded devices in far‐field speech recognition, we propose a deep learning neural network model with multitask learning. First, the audio is passed through the end‐to‐end noise reduction model to improve the effect of audio recognition. Then we define dialect recognition as the main task and dialect area as the auxiliary task, using the multitask learning method to improve the accuracy of dialect classification. The experimental results show that the end‐to‐end noise reduction model can improve the accuracy of audio recognition, and the best effect can be 7.54% higher than the baseline, and the accuracy of dialect language recognition can be improved by about 5% through multi task learning model.
A secure finger vein verification and authentication scheme for banking network
Authors: D Jebakumar Immanuel , R Dhanapal 
Published: August 2022

SummaryThe development of electronic exchanges has created a more important interest in fast and accurate customer IDs and verification. Structures, bank records, and PC framework often use personally identifiable access code IDs and test numbers (PINs) for reliable status. Biometric verification requires a level of security, unchanged structure, spoofing, and reliability. In this research work, a biometric authentication system was developed to provide security for access to the ATM network. Honest technology used for security purposes to provide efficient ATM network security is a finger vein. This method undergoes image processing technology such as preprocessing, feature extraction, and classification to locate the finger vein region for accessing the ATM network. Finally, the cascade neural network acts as a classifier method to differentiate registered and unregistered user. The performance analysis of this method is simulated by MATLAB and the process is evaluated to measure the efficient security of the network. The dataset is segregated into two stages; one for training and other for testing. The features extracted with the help of hidden layers with neurons. The matched finger vein is compared to check the accuracy.
Benzodithiophene‐Based, Donor–Acceptor–π–Donor–Acceptor Systems as Hole Transporting Materials for Efficient Perovskite Solar Cells
Authors: Manda Kishore , Kore Ranjith , Ambapuram Meenakshamma , Chetti Prabhakar , Roy Subhrangsu , Jadhav Vinod D. , Babu S. Narendra , Gundla Rambabu , Mitty Raghavender , Pola Someshwar 
Published: August 2022

AbstractFour new donor–acceptor–π‐bridge–accepter–donor hole‐transporting materials (HTMs) were developed based on the 2,2′‐(4,8‐bis(octyloxy)benzo[1,2‐b:4,5‐b′]dithiophene (OBDT) core moiety functionalised with two diphenylamine‐based donor units as outlying moieties. The compounds were designed, synthesised and used in perovskite solar cells (PSCs). Each HTM was thoroughly characterized with various spectroscopic techniques, and the surface and cross‐sectional morphologies of the thin‐film topmost layer, steady‐state photoluminescence, hole mobility and PSC efficiency were estimated and correlated with a standard Spiro‐OMeTAD HTM. The stabilized photocurrent and power conversion efficiency (PCE) measurements at maximum power point tracking, and J‐Voc curves under forward, and reverse bias, were studied. The film of the methyl‐substituted derivative provided a very consistent and compact protected layer to the whole perovskite layer, which is the key to the enhancement of the Voc and fill factor (FF). The PSC device based on the methyl derivative as HTM showed a high PCE of 19.07 % (active area 0.42 cm2) which is compared to the SpiroOMeTAD control device (17.90 %; active area 0.42 cm2). Optimized devices retained about 90 % PCE for 60 days, suggesting the reported HTM framework as a promising material for PSC application, considering also that they are tuneable and can be synthesized on a large scale.
Molecular testing in fine‐needle aspiration of thyroid nodules
Authors: McMurtry Valarie , Canberk Sule , Deftereos Georgios 
Published: August 2022

AbstractBackgroundThyroid nodules are commonly faced by clinicians as palpable nodules or incidentally identified on imaging. Nodules that are found to be suspicious by imaging can be biopsied by fine needle aspiration, which can yield material for molecular testing to refine the diagnosis.MethodsThe current literature concerning molecular testing in thyroid nodules including available commercial assays was reviewed and summarized.Results/ConclusionsCommonly encountered alterations include mutations in RAS, BRAF, TERT promoter, PTEN, and DICER1 as well as fusions of RET, ALK, PAX8‐PPARγ, and NTRK. This article provides a summary of these molecular alterations, commercially available molecular assays, and general considerations for thyroid epithelial malignancies and benign thyroid nodules.
Prognostic value of right atrial pressure‐corrected cardiac power index in cardiogenic shock
Authors: Baldetti Luca , Pagnesi Matteo , Gallone Guglielmo , Barone Giuseppe , Fierro Nicolai , Calvo Francesco , Gramegna Mario , Pazzanese Vittorio , Venuti Angela , Sacchi Stefania , De Ferrari Gaetano Maria , Burkhoff Daniel , Lim Hoong Sern , Cappelletti Alberto Maria 
Published: August 2022

AbstractAimThe pulmonary artery catheter (PAC)‐derived cardiac power index (CPI) has been found of prognostic value in cardiogenic shock (CS) patients. The original CPI equation included the right atrial pressure (RAP), accounting for heart filling pressure as a determinant of systolic myocardial work, but this term was subsequently omitted. We hypothesized that the original CPI formula (CPIRAP) is superior to current CPI for risk stratification in CS.Methods and resultsA single‐centre cohort of 80 consecutive Society for Cardiovascular Angiography and Interventions (SCAI) B‐D CS patients with available PAC records was included. Overall in‐hospital mortality was 21.3%. Results showed CPIRAP to be the strongest haemodynamic predictor of in‐hospital death (padj = 0.038), outperforming CPI [area under the receiver operating characteristic (ROC) curves: 0.726 and 0.673, P‐for‐difference = 0.025]. When the population was stratified according to the identified CPIRAP (0.28 W/m2) and accepted CPI (0.32 W/m2) thresholds, the cohort with discordant indexes (low CPIRAP and high CPI) comprised a group of 13 patients featuring a congested phenotype with frequent right ventricle or biventricular involvement. In this group, in‐hospital mortality was high (30.8%) similar to those with concordant low CPI and CPIRAP.ConclusionIncorporating RAP in CPI calculation (CPIRAP) improves the prognostic yield in patients with CS SCAI B‐D. A cut‐off of 0.28 W/m2 identifies patients at higher risk of in‐hospital mortality. The improved prognostic value of CPIRAP may derive from identification of patients with more intravascular congestion who may experience substantial in‐hospital mortality, uncaptured by the commonly used CPI equation.
Dapagliflozin and New York Heart Association functional class in heart failure with mildly reduced or preserved ejection fraction: the DELIVER trial
Authors: Ostrominski John W. , Vaduganathan Muthiah , Claggett Brian L. , de Boer Rudolf A. , Desai Akshay S. , Dobreanu Dan , Hernandez Adrian F. , Inzucchi Silvio E. , Jhund Pardeep S. , Kosiborod Mikhail , Lam Carolyn S.P. , Langkilde Anna M. , Lindholm Daniel , Martinez Felipe A. , O'Meara Eileen , Petersson Magnus , Shah Sanjiv J. , Thierer Jorge , McMurray John J.V. , Solomon Scott D. 
Published: August 2022

AimsThis pre‐specified analysis of the DELIVER trial examined whether clinical benefits of dapagliflozin in heart failure (HF) with left ventricular ejection fraction (LVEF) >40% varied by baseline New York Heart Association (NYHA) class and examined the treatment effects on NYHA class over time.Methods and resultsTreatment effects of dapagliflozin by baseline NYHA class II (n = 4713) versus III/IV (n = 1549) were examined on the primary endpoint (cardiovascular death or worsening HF event) and key secondary endpoints. Effects of dapagliflozin on change in NYHA class at 4, 16, and 32 weeks were also evaluated. Higher baseline NYHA class was associated with older age, female sex, greater comorbidity burden, lower LVEF, and higher natriuretic peptide levels. Participants with baseline NYHA class III/IV, as compared with II, were independently more likely to experience the primary endpoint (adjusted hazard ratio [HR] 1.16 [95% confidence interval, 1.02–1.33]) and all‐cause death (adjusted HR 1.22 [1.06–1.40]). Dapagliflozin consistently reduced the risk of the primary endpoint compared with placebo, irrespective of baseline NYHA class (HR 0.81 [0.70–0.94] for NYHA class II vs. HR 0.80 [0.65–0.98] for NYHA class III/IV; pinteraction = 0.921). Participants with NYHA class III/IV had greater improvement in Kansas City Cardiomyopathy Questionnaire total symptom scores between baseline and 32 weeks (+4.8 [2.5–7.1]) versus NYHA class II (+1.8 [0.7–2.9]; pinteraction = 0.011). Dapagliflozin was associated with higher odds of any improvement in NYHA class (odds ratio [OR] 1.32 [1.16–1.51]), as well as improvement to NYHA class I (OR 1.43 [1.17–1.75]), versus placebo at 32 weeks, with benefits seen as early as 4 weeks.ConclusionsAmong symptomatic patients with HF and LVEF >40%, treatment with dapagliflozin provided clinical benefit irrespective of baseline NYHA class and was associated with early and sustained improvements in NYHA class over time.
Effects of family functioning on eating pathology and psychosocial quality of life: The mediating role of self‐esteem
Authors: Theodoropoulou Olga , Gardner Kathryn Jane , Caswell Noreen , Holyoak Lynda , Gonidakis Fragiskos 
Published: August 2022

AbstractObjectiveFamily dysfunction and self‐esteem play an important role in the development of eating disorders (EDs), but this role has not been sufficiently examined regarding eating pathology and psychosocial quality of life (QoL), which often remains unchanged even after ED symptoms reduce. The purpose of this study was to therefore assess the mediating role of self‐esteem between family dysfunction and both eating pathology and psychosocial QoL in ED patients and controls.MethodOne hundred and fifty four female adult ED patients and 154 female healthy adult controls were recruited from Athens, Greece, and self‐reported measures were used to assess family dysfunction, eating pathology, self‐esteem, and psychosocial QoL. Structural equation modelling (SEM) was employed to test the mediation hypotheses.ResultsFor both the ED and control groups, family dysfunction levels did impact eating pathology, but only through self‐esteem. Family dysfunction, self‐esteem, and eating pathology had a direct effect on both groups' psychosocial QoL.ConclusionSelf‐esteem's important role in EDs was confirmed in both groups, along with its sensitivity to family dysfunction. We propose a parsimonious yet comprehensive theoretical model of the role of family dysfunction and self‐esteem in EDs which future studies should further investigate longitudinally and in other population groups.
AGAP3: A novel BRAF fusion partner in pediatric pancreatic‐type acinar cell carcinoma
Authors: Paoli Charlotte , Burel‐Vandenbos Fanny , Coulomb‐l'Hermine Aurore , Cros Jérôme , Pondrom Morgane , Kubiniek Valérie , Pedeutour Florence , Dadone‐Montaudié Bérengère 
Published: August 2022

AbstractMost available molecular data on pancreatic acinar cell carcinoma (PACC) are provided by studies of adult cases. BRAF, RAF1, or RET rearrangements have been described in approximately 30% of cases. To the best of our knowledge, only seven cases with molecular data have been reported in pediatric PACC. We report here the comprehensive study of a pancreatic‐type ACC from a 6‐year‐old patient. We detected an AGAP3::BRAF fusion. This result showing a BRAF rearrangement demonstrates a molecular link between adult and pediatric PACC. Moreover, it identifies AGAP3, a gene located at 7q36.1 that encodes a major component of the N‐methyl‐d‐aspartate (NMDA) receptor signaling complex, as a partner gene of BRAF. The variability of BRAF partners is consistent with a driver role of BRAF alterations in PACC. The identification of such alterations is noteworthy for considering the use of MEK inhibitors in metastatic cases. We did not detect associated genomic instability. The better outcome of pediatric cases might be related to their stable genomic background.
Investigation of the functional pathogenesis of mild cognitive impairment by localisation‐based locus coeruleus resting‐state fMRI
Authors: Liebe Thomas , Dordevic Milos , Kaufmann Jörn , Avetisyan Araks , Skalej Martin , Müller Notger 
Published: August 2022

AbstractDementia as one of the most prevalent diseases urges for a better understanding of the central mechanisms responsible for clinical symptoms, and necessitates improvement of actual diagnostic capabilities. The brainstem nucleus locus coeruleus (LC) is a promising target for early diagnosis because of its early structural alterations and its relationship to the functional disturbances in the patients. In this study, we applied our improved method of localisation‐based LC resting‐state fMRI to investigate the differences in central sensory signal processing when comparing functional connectivity (fc) of a patient group with mild cognitive impairment (MCI, n = 28) and an age‐matched healthy control group (n = 29). MCI and control participants could be differentiated in their Mini‐Mental‐State‐Examination (MMSE) scores (p < .001) and LC intensity ratio (p = .010). In the fMRI, LC fc to anterior cingulate cortex (FDR p < .001) and left anterior insula (FDR p = .012) was elevated, and LC fc to right temporoparietal junction (rTPJ, FDR p = .012) and posterior cingulate cortex (PCC, FDR p = .021) was decreased in the patient group. Importantly, LC to rTPJ connectivity was also positively correlated to MMSE scores in MCI patients (p = .017). Furthermore, we found a hyperactivation of the left‐insula salience network in the MCI patients. Our results and our proposed disease model shed new light on the functional pathogenesis of MCI by directing to attentional network disturbances, which could aid new therapeutic strategies and provide a marker for diagnosis and prediction of disease progression.
Early‐stage vocal cord cancer treated with hypofractionated radiotherapy to the larynx with or without concurrent chemotherapy
Authors: de Leo Alexandra N. , Dagan Roi , Morris Christopher G. , Holtzman Adam L. , Hitchcock Kathryn E. , Bryant Curtis M. , Amdur Robert J. , Mendenhall William M. 
Published: August 2022

AbstractBackgroundWe report outcomes among patients with T2 and select T3 glottic squamous cell carcinoma (SCC) treated with radiotherapy.MethodsWe reviewed T2 and T3 (only paraglottic space invasion) N0 M0 glottic SCC patients treated with curative‐intent hypofractionated larynx radiotherapy, with or without concurrent systemic therapy.ResultsOf 71 patients, those who received concurrent chemotherapy (23/71; 32%) had worse prognostic factors, including impaired cord mobility (70% vs. 40%,p = 0.02) and larger median gross tumor volume (3.0 vs. 1.6 cm3,p = 0.003). Over a median follow‐up of 3.8 years, 2‐year local control among patients with impaired cord mobility appeared higher for those who received chemotherapy (88% vs. 61%,p = 0.12), but the difference was not statistically significant. Acute and late toxicity rates were not higher among patients who received chemotherapy.ConclusionsThe addition of concurrent platinum‐based chemotherapy to hypofractionated larynx radiotherapy among patients with early‐stage glottic SCC with impaired cord mobility appears safe and worthy of additional investigation.
The state of abortion rights in the US
Authors: Davis Martha F. 
Published: August 2022

AbstractIn Dobbs v. Jackson Women's Health Organization (2022), the US Supreme Court reversed longstanding court precedents that protected abortion as a fundamental right. Without that federal baseline, many states are passing restrictive laws that threaten providers and complicate patient care. The legal issues raised by these state restrictions are complex, including questions such as the exterritorial application of state restrictions and federal authority to regulate access to medication abortion. Meanwhile, providers who risk criminal or civil penalties for violating these laws may be deterred from providing services to those seeking care, including for ectopic pregnancies and miscarriages. State variations are dramatic, with some states taking steps to strengthen their abortion protections while others are eliminating abortion access even in situations of rape or incest. As dire as these developments are, it is hoped that they can serve as a wake‐up call heard worldwide, to avoid complacency and maintain vigilance to protect abortion rights.