bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated water recycle (AWR) method for dust removal from rooftop photovoltaic (PV) at Johor, Malaysia
Authors: Islam Syed Zahurul , Izzati Nur Syahirah , Abdullah Mohd Noor , Kamarudin Muhammad Saufi , Omar Rosli , Uddin Jasim 
Published: October 2022

Abstract
Wet dust on the Photovoltaic (PV) surface is a persistent problem that is merely considered for rooftop based PV cleaning under a high humid climate like Malaysia. This paper proposes an Automated Water Recycle (AWR) method encompassing a water recycling unit for rooftop PV cleaning with the aim to enhance the electrical performance. This study makes a major contribution by developing a new model to correlate output power ($$P_{out}$$

P

out

) and dust-fall factor. For model validation, we conducted an experiment of taking one set of Monocrystalline PV (mono) on a $$340\frac{W}{m^{2}}$$

340

W

m
2

of medium luminance day. One mono module was cleaned by AWR - pressurized water sprayed through 11 small holes over its front surface, while the other module was left with no-cleaning. The dust-contaminated water was filtered and collected back to the tank for recycling process. The water loss per cleaning cycle was achieved 0.32%, which was normalized to net loss of 28.8% at a frequency of 1 cycle/day for 90 days of operation. We observed that $$P_{out}$$

P

out

of no-cleaning PV was decreased by 29.44% than that of AWR method. From this experimental data also, a unique and more accurate model is created for $$P_{out}$$

P

out

prediction, which is much simpler compared to multivariables equation. Our investigation offers important insights into the accuracy of this regression model demonstrated by $$R^{2}=0.744$$

R
2

=
0.744

or a strong negative quadratic relationship between $$P_{out}$$

P

out

and dust-fall. The cleaning of PV modules is expected to save significant energy to reduce the payback period.

Article Highlights

An automated water recycle method for cleaning dust-fall in rooftop photovoltaic module is proposed.

Both simulation and experimental models are developed to predict output power of the photovoltaic module.

Proposed method can produce 24.40% more output power than a no-cleaning system with a mere water loss of 0.32%/cycle.
A step-by-step approach to patients leaving against medical advice (AMA) in the emergency department
Authors: Trépanier Gabrielle , Laguë Guylaine , Dorimain Marie Victoria 
Published: October 2022

Abstract
Objectives
Patients leaving against medical advice (AMA) can be distressing for emergency physicians trying to navigate the medical, social, psychological, and legal ramifications of the situation in a fast-paced and chaotic environment. To guide physicians in fulfilling their obligation of care, we aimed to synthesize the best approaches to patients leaving AMA.

Methods
We conducted a scoping review across various fields of work, research context and methodology to synthesize the most relevant strategies for emergency physicians attending patients leaving AMA. We searched Medline, CINAHL, PSYCHO Legal Source, PsycINFO, PsycEXTRA, Psychological and Behavioural Sciences collection, SocIndex and Scopus. Search strategies included controlled vocabulary (i.e., MESH) and keywords relevant to the subject chosen by a team of four people, including two specialized librarians.

Results
The literature review included 34 relevant papers about approaches to patients leaving AMA: 8 case presentations, 4 ethical case analyses, 10 legal letters, 4 reviews and 8 original studies. The main identified strategies were prioritizing a patient-centered approach, proposing alternative discharge and reducing harm while properly documenting the encounter.

Conclusion
A systematic approach to patients leaving AMA could help improve patient care, support physicians and decrease stigmatization of this population. We advocate that emergency physicians should receive training on how to approach patients leaving AMA to limit the impact on this vulnerable population.
Chemical compositions, fatty acid profiles and selected contaminants in commercial potato and corn chips sold in the Tunisian market
Authors: Benkhoud Haifa , Mrabet Yassine , Nasraoui Nadia , Bellazreg Wided , Daly Faten , Chaabane Najet , Hosni Karim 
Published: October 2022

AbstractIn the last decades, the snack food market is experiencing an important expansion due to the new fast-paced life-style associated with modernization. Crispy snacks, or chips are the most popular snack around the world, nevertheless, their overconsumption is related to the incidence of many diseases. Subsequently, this work aimed to study the chemical composition of 13 brands of potato and corn chips available in the Tunisian market. The investigation was based on: the determination of their chemical, mineral, and fatty acid composition; an evaluation of their lipid quality indices; and a chromatographic analysis of pesticides, aromatic hydrocarbons and acrylamide content. The results showed that the chips samples were of a high carbohydrate and fat content of up to 64.54% and 42.98%, respectively, versus a low protein and mineral composition. The fatty acid profiling showed that saturated fatty acids represent more than 39% for the majority of samples. A poor lipid quality was also observed through their low unsaturated fatty acids /saturated Fatty Acids ratios, with a mean value of 2.24 and their high atherogenic and thrombogenic indices that reached 1.69 and 2.23 respectively. While the analysis of pesticide residues and polycyclic aromatic hydrocarbons showed that all compounds were below the maximum allowed levels, the acrylamide analysis highlighted contamination in all the samples tested, with some values exceeding the allowed threshold. In conclusion, it can be suggested that the crisps sold in the Tunisian market are of a poor nutritional quality and they are potentially unsafe for human consumption.
Factors governing the adoption of artificial intelligence in healthcare providers
Authors: Davenport Thomas H. , Glaser John P. 
Published: October 2022

AbstractArtificial intelligence applications are prevalent in the research lab and in startups, but relatively few have found their way into healthcare provider organizations. Adoption of AI innovations in consumer and business domains is typically much faster. While such delays are frustrating to those who believe in the potential of AI to transform healthcare, they are largely inherent in the structure and function of provider organizations. This article reviews the factors that govern adoption and explains why adoption has taken place at a slow pace. Research sources for the article include interviews with provider executives, healthcare IT professors and consultants, and AI vendor executives. The article considers differential speed of adoption in clinical vs. administrative applications, regulatory approval issues, reimbursement and return on investments in healthcare AI, data sources and integration with electronic health record systems, the need for clinical education, issues involving fit with clinical workflows, and ethical considerations. It concludes with a discussion of how provider organizations can successfully plan for organizational deployment.
PlantCADB: A Comprehensive Plant Chromatin Accessibility Database
Authors: Ding Ke , Sun Shanwen , Luo Yang , Long Chaoyue , Zhai Jingwen , Zhai Yixiao , Wang Guohua 
Published: October 2022

Abstract
Chromatin accessibility landscapes are essential for detecting regulatory elements, illustrating the corresponding regulatory networks, and, ultimately, understanding the molecular basis underlying key biological processes. With the advancement of sequencing technologies, a large volume of chromatin accessibility data has been accumulated and integrated for humans and other mammals. These data have greatly advanced the study of disease pathogenesis, cancer survival prognosis, and tissue development. To advance the understanding of molecular mechanisms regulating plant key traits and biological processes, we developed a comprehensive plant chromatin accessibility database (PlantCADB) from 649 samples of 37 species. These samples are abiotic stress-related (such as heat, cold, drought, and salt; 159 samples), development-related (232 samples), and/or tissue-specific (376 samples). Overall, 18,339,426 accessible chromatin regions (ACRs) were compiled. These ACRs were annotated with genomic information, associated genes, transcription factor footprint, motif, and single-nucleotide polymorphisms (SNPs). Additionally, PlantCADB provides various tools to visualize ACRs and corresponding annotations. It thus forms an integrated, annotated, and analyzed plant-related chromatin accessibility resource, which can aid in better understanding genetic regulatory networks underlying development, important traits, stress adaptations, and evolution. PlantCADB is freely available at https://bioinfor.nefu.edu.cn/PlantCADB/.
Observational and clinical evidence that plant-based nutrition reduces dietary acid load
Authors: Storz Maximilian A. , Ronco Alvaro L. , Hannibal Luciana 
Published: October 2022

Abstract
Contemporary diets in Western countries are largely acid-inducing and deficient in potassium alkali salts, resulting in low-grade metabolic acidosis. The chronic consumption of acidogenic diets abundant in animal-based foods (meats, dairy, cheese and eggs) poses a substantial challenge to the human body's buffering capacities and chronic retention of acid wherein the progressive loss of bicarbonate stores can cause cellular and tissue damage. An elevated dietary acid load (DAL) has been associated with systemic inflammation and other adverse metabolic conditions. In this narrative review, we examine DAL quantification methods and index observational and clinical evidence on the role of plant-based diets, chiefly vegetarian and vegan, in reducing DAL. Quantitation of protein and amino acid composition and of intake of alkalising organic potassium salts and magnesium show that plant-based diets are most effective at reducing DAL. Results from clinical studies and recommendations in the form of expert committee opinions suggest that for a number of common illnesses, wherein metabolic acidosis is a contributing factor, the regular inclusion of plant-based foods offers measurable benefits for disease prevention and management. Based on available evidence, dietary shifts toward plant-based nutrition effectively reduces dietary-induced, low-grade metabolic acidosis.
INFLATION DIFFERENTIALS AMONG EUROPEAN MONETARY UNION COUNTRIES: AN EMPIRICAL EVALUATION WITH STRUCTURAL BREAKS
Authors: Stylianou Tasos 
Published: October 2022

AbstractInflation rates and their convergence within Euro area have been a major concern, since well before the advent of the single currency. Inflation differentials are a normal phenomenon in any monetary union and even in long-established monetary unions. The aim of this research is to examine the main factors of inflation differentials in the Euro-zone for the period 1999–2018. Our empirical estimates appear to suggest that a one-percentage-point increase in the positive output gap typically leads to an increase of about 20 basis points in the inflation rate of EMU countries. We also find three structural breaks, in 2004, 2008 and in 2010. Since the monetary policy of the European Central Bank is geared at maintaining low and stable inflation, the productivity growth should be increased, and the real effective exchange rates should be decreased and become more homogeneous among EMU. Therefore, countries’ inflation differentials may become less persistent.
Journeymen Migration and Settlement in Eighteenth-century Holland
Authors: Groot Piet , Schalk Ruben 
Published: October 2022

AbstractMany crafts in premodern Europe depended on migratory journeymen. Little is known about these workers, or how craft guilds and urban authorities affected their movement. By employing novel data on thousands of journeymen from different crafts and cities in Holland, we provide the first systematic overview of journeymen migration and settlement patterns in The Dutch Republic. We find that migration and settlement patterns differed significantly by occupational sector, marital status, and skill level. The stance of urban authorities towards migrants significantly affected settlement patterns as well. This interrelation of group-level characteristics, craft guilds, and urban regulation demonstrates the significance of examining these elements in tandem.
Self-Respect Paternalism
Authors: Midtgaard Søren Flinch 
Published: October 2022

AbstractAccording to the influential disrespect account of what paternalism is, and why it is wrong, paternalism involves an anti-egalitarian, disrespectful attitude on the part of the paternalist: X (the paternalist) assumes an attitude of superiority when interfering in Y's matters for Y's good. Pace this account, the article argues that an important, although somewhat overlooked, form of paternalism is not, all things considered, insulting. This form of paternalism focusses on people's occasional lack of appropriate self-respect or their failure to see themselves as equals or to stand vis-à-vis others as such.
Fair Evaluation of Orientation‐Averaging Techniques in Light‐Scattering Simulations: Comment on “Evaluation of Higher‐Order Quadrature Schemes in Improving Computational Efficiency for Orientation‐Averaged Single‐Scattering Properties of Nonspherical Ice Particles” by Fenni et al
Authors: Yurkin Maxim A. 
Published: October 2022

AbstractIn a recent paper Fenni et al. (2021, https://doi.org/10.1029/2020jd034172) compared the code MIDAS, based on the direct solution of the volume‐integral equation combined with advanced cubatures for orientation averaging, to the code DDSCAT, a state‐of‐the‐art implementation of the discrete dipole approximation. This comment highlights methodological issues in this comparison and shows that the quantitative claims of Fenni et al. (2021, https://doi.org/10.1029/2020jd034172), related to superiority of MIDAS over DDSCAT, are based on very specific test cases with respect to particle symmetries or initial orientation, as well as to the selected scattering quantity of interest. Thus, these claims are not expected to hold for other similar particles. Moreover, the detailed discussion of these issues is relevant for all light‐scattering simulation methods, except those allowing analytical orientation averaging. Thus, the comment constructs general guidelines for fair evaluation of orientation‐averaging techniques in a wide range of light‐scattering methods and computer codes.
Melting and Refreezing in an Ice Shelf Basal Channel at the Grounding Line of the Kamb Ice Stream, West Antarctica
Authors: Whiteford A. , Horgan H. J. , Leong W. J. , Forbes M. 
Published: October 2022

AbstractIce shelves buttress ice streams and glaciers, slowing the rate at which they flow into the ocean. When this buttressing is reduced, either through increased melt or calving, the increased discharge of grounded ice upstream contributes to sea level rise. The thickness, strength, and stability of ice shelves can be influenced by channels in the ice base. Here, we focus on a subglacially sourced basal channel which is observed to have melted up to 50% of the ice shelf thickness. The channel extends 6 km upstream of the previously estimated grounding line of the stagnant Kamb Ice Stream. Using a combination of ground–based observations and remote sensing, we find that the channel is growing upstream over time. Over–snow radar surveying images the shape of the channel, constrains a steep inception, and shows that not all of the basal shape is manifest at the surface. Modern surface lowering at the upstream head of the channel is interpreted as a region of focused melt where a subglacial outlet meets the ocean cavity. We estimate this basal melt to be at least 35 m/a in a narrow (200 m × 1.5 km) zone. Downstream from the melt region, repeat phase sensitive radar observations reveal accretion contributing to the growth of a ledge on the true–right side of the channel. We conclude that the channel is likely formed by a retreating subglacial outlet which enhances basal melt episodically.
The Freshwater Balance of the Adriatic Sea: A Sensitivity Study
Authors: Vodopivec Martin , Zaimi Klodian , Peliz Álvaro J. 
Published: October 2022

AbstractThe Adriatic Sea is a narrow semi‐enclosed basin with considerable freshwater inflow, connected to the saltier Mediterranean Sea through a narrow strait. The northern and central parts of the basin are characterized by a shallow shelf, while the southern part features a pit exceeding 1,200 m in depth. We conducted a series of modeling experiments over a 16‐year period (2000–2015) using different runoff configurations and different sources of atmospheric forcing to investigate the sensitivity of the Adriatic Sea circulation and hydrology to freshwater balance and heat loss. Our results show that the shelf salinity and the salinity of the surface layers in the southern Adriatic are part of a self‐amplifying loop involving dense water formation, water exchange with the Mediterranean Sea, and salty water intrusions to the shelf. Therefore, the characteristics of the basin and the water circulation are highly sensitive to the freshwater budget and heat losses. River discharge is subject to large interannual variations and is poorly known for many of the Adriatic freshwater sources. To improve the accuracy of the freshwater budget, we created a new climatology for three Albanian rivers and modulated the monthly climatological discharge in accordance with the rivers Po and Isonzo (Soča). Evaporation, precipitation, and heat losses vary strongly among the available atmospheric reanalyses and we show that the choice of atmospheric forcing has a substantial impact on the hydrology and circulation of the Adriatic Sea.
Targeting the cholesterol-RORα/γ axis inhibits colorectal cancer progression through degrading c-myc
Authors: Wang Ying-Nan , Ruan Dan-Yun , Wang Zi-Xian , Yu Kai , Rong Dai-Lin , Liu Ze-Xian , Wang Feng , Hu Jia-Jia , Jin Ying , Wu Qi-Nian , Pu Heng-Ying , Wang Min , Xu Rui-Hua , Zeng Zhao-Lei 
Published: October 2022

AbstractDysregulated cholesterol metabolism is a hallmark of colorectal cancer (CRC). However, the usage of cholesterol-lowering agents seemed to have no benefit in CRC patients. In this study, we focused on the cholesterol-nuclear receptors (NRs) axis as a strategy. Cholesterol and its derivatives work as ligands for different nuclear receptors, thus promoting cancer progression. The key NR downstream of cholesterol in CRC is unknown. Here, we treated CRC cells with a cholesterol-lowering agent and lipoprotein-depleted conditioned medium, and then detected the change of the putative NRs. The results revealed that RORα/γ (Retinoic acid receptor-related Orphan Receptor α/γ) levels exhibited the most obvious increases in CRC cells subjected them to cholesterol deprivation. RORα/γ agonists significantly inhibited CRC cells proliferation and migration in vitro and in vivo. Also, RORα/γ overexpression repressed CRC cells proliferation and migration in vitro and in vivo and RORα/γ knockdown promoted it. Mechanistically, RORα/γ agonists promoted c-myc degradation by activating the transcription of the ubiquitinase NEDD4. Intriguingly, the combination of RORα/γ agonists and atorvastatin had a synergistic effect on inhibiting CRC cells. These findings demonstrate that the cholesterol- RORα/γ axis is important for maintaining c-myc protein levels. Combination therapy with atorvastatin and RORα/γ agonist is a promising therapeutic strategy for CRC.
CUR5g, a novel autophagy inhibitor, exhibits potent synergistic anticancer effects with cisplatin against non-small-cell lung cancer
Authors: Chen Jingxuan , Shen Yunpeng , Wu Bowen , Yang Peichang , Sun Gangchun , Liu Xiaoting , Qiang Pengfei , Gao Yamei , Sha Fangfang , Li Zirui , Zhang Lu 
Published: October 2022

AbstractAutophagy, a highly conserved degradation process of eukaryotic cells, has been proven to be closely related to chemoresistance and metastasis of non-small-cell lung cancer (NSCLC). Autophagy inhibitors, such as chloroquine (CQ) and its derivative hydroxychloroquine (HCQ), has been shown to mediate anticancer effects in preclinical models, especially when combined with chemotherapy. However, the vast majority of autophagy inhibitors, including CQ and HCQ, actually disrupt lysosomal or/and possibly non-lysosomal processes other than autophagy. It is therefore of great significance to discover more specific autophagy inhibitors. In this study, after screening a series of curcumin derivatives synthesized in our laboratory, we found that (3E,5E)-1-methyl-3-(4-hydroxybenzylidene)-5-(3-indolymethylene)-piperidine-4-one (CUR5g) selectively inhibited autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g did not affect the lysosomal pH and proteolytic function, nor did it disturb cytoskeleton. CUR5g blocked the recruitment of STX17, a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein, to autophagosomes via a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. CUR5g alone did not induce apoptosis and necrosis of A549 cells, but significantly inhibited the mobility and colony formation of A549 cells. More excitingly, CUR5g showed no obvious toxicity to normal HUVECs in vitro or mice in vivo. CUR5g enhances the cisplatin sensitivity of A549 cells and effectively inhibited autophagy in tumor tissues in vivo. Collectively, our study identified a new late-stage autophagy inhibitor and provided a novel option for NSCLC treatment, particular when combined with cisplatin.
DNAJA1- and conformational mutant p53-dependent inhibition of cancer cell migration by a novel compound identified through a virtual screen
Authors: Nishikawa Shigeto , Kaida Atsushi , Parrales Alejandro , Ranjan Atul , Alalem Mohamed , Ren Hongyi , Schoenen Frank J. , Johnson David K. , Iwakuma Tomoo 
Published: October 2022

AbstractCancers are frequently addicted to oncogenic missense mutant p53 (mutp53). DNAJA1, a member of heat shock protein 40 (HSP40), also known as J-domain proteins (JDPs), plays a crucial role in the stabilization and oncogenic activity of misfolded or conformational mutp53 by binding to and preventing mutp53 from proteasomal degradation. However, strategies to deplete mutp53 are not well-established, and no HSP40/JDPs inhibitors are clinically available. To identify compounds that bind to DNAJA1 and induce mutp53 degradation, we performed an in silico docking study of ~10 million of compounds from the ZINC database for the J-domain of DNAJA1. A compound 7-3 was identified, and its analogue A11 effectively reduced the levels of DNAJA1 and conformational mutp53 with minimal effects on the levels of wild-type p53 and DNA-contact mutp53. A11 suppressed migration and filopodia formation in a manner dependent on DNAJA1 and conformational mutp53. A mutant DNAJA1 with alanine mutations at predicted amino acids (tyrosine 7, lysine 44, and glutamine 47) failed to bind to A11. Cells expressing the mutant DNAJA1 became insensitive to A11-mediated depletion of DNAJA1 and mutp53 as well as A11-mediated inhibition of cell migration. Thus, A11 is the first HSP40/JDP inhibitor that has not been previously characterized for depleting DNAJA1 and subsequently conformational mutp53, leading to inhibition of cancer cell migration. A11 can be exploited for a novel treatment against cancers expressing conformational mutp53.