bluuebunny/crossref_metadata_2025_split huggingface dataset:
Os cuidados paliativos no âmbito dos cuidados de saúde primários
Authors: Coelho de Carvalho Sandra da Conceição , Rebelo Botelho Maria Antónia 
Published: September 2022

Estando em curso a Reforma dos Cuidados de Saúde Primários e anunciando-se para breve a entrada em funcionamento de Unidades de Cuidados Paliativos de Nível I e II, tornou-se pertinente compreender como é que os enfermeiros dos Cuidados de Saúde Primários respondem às necessidades da pessoa em sofrimento intenso na fase final de vida, no sentido que daí possa resultar não só uma melhor adequação dos recursos às necessidades, mas também um incremento positivo na qualidade das respostas.
Como contribuição para atingir essa meta, foi projectada uma investigação de carácter exploratório - descritivo, com uma abordagem qualitativa, usando como técnica de recolha de dados a entrevista semi-estruturada. Neste artigo, de entre os diferentes objectivos específicos orientadores do respectivo estudo, restringimo-nos à identificação das acções paliativas que os referidos enfermeiros prestam aos utentes nas condições indicadas e à análise das suas percepções relativas aos cuidados prestados e aos resultados obtidos nesse âmbito.
Dos achados do estudo depreende-se que, na situação actual, o Centro de Saúde a que pertencem os enfermeiros envolvidos no estudo não lhes possibilita responderem de forma adequada e completa à multiplicidade e complexidade das necessidades com que se deparam.

* Este artigo retoma parte da tese de mestrado da 1.ª autora, apresentada no Instituto de Ciências da Saúde da Universidade Católica Portuguesa – Porto e orientada pela outra autora. A respectiva tese foi defendida em Julho de 2010, com o título O Enfermeiro dos Cuidados de Saúde Primários perante as Necessidades da Pessoa em Sofrimento Intenso na Fase Final de Vida: O Quotidiano dos Cuidados de Enfermagem no Distrito de Viana do Castelo.
PENGARUH SISTEM INTERNAL KONTROL , KOMPETENSI MANAJERIAL TERHADAP TATA KELOLA DAN KINERJA PERBANKAN PROVINSI SULAWESI SELATAN
Authors: Dahyar Nirwan 
Published: September 2022

Tujuan penelitian ini untuk menganalisis pengaruh sistem internal kontrol terhadap tata kelola, pengaruh kompetensi manajerial terhadap tata kelola, pengaruh sistem internal kontrol melalui tata kelola terhadap kinerja perbankan, pengaruh kompetensi manajerial melalui tata kelola terhadap kinerja perbankan dan pengaruh tata kelola terhadap kinerja perbankan di Provinsi Sulawesi Selatan.
Penelitian dilaksanakan pada Perbankan di Provinsi Sulawesi Selatan dengan populasi yaitu manajer bagian audit dan keuangan sebanyak 648 orang dan sampel sebanyak 247 responden berdasarkan rumus Slovin. Data hasil kuesioner dianalisis menggunakan Structural Equation Model menggunakan bantuan AMOS 18.
Hasil penelitian menemukan sistem internal kontrol secara langsung berpengaruh positif dan tidak signifikan terhadap kinerja perbankan. Berarti sistem internal kontrol sudah diterapkan, namun belum mampu mencapai hasil yang sesuai input, process, output, outcome, benefit dan impact sebagai penilaian kinerja perbankan. Sistem kontrol internal secara tidak langsung berpengaruh negatif dan tidak signifikan terhadap kinerja perbankan melalui tata kelola. Berarti perlu perbaikan dalam sistem pengendalian internal organisasi yang sesuai dengan prinsip ketatalaksanaan bidang keuangan untuk meningkatkan kinerja perbankan. Kompetensi manajerial secara langsung berpengaruh dominan positif dan signifikan terhadap kinerja perbankan. Berarti kompetensi manajerial yang dimiliki pegawai sudah baik dan mendukung pencapaian hasil kerja di bidang keuangan yang sesuai input, process, output, outcome, benefit dan impact sebagai penilaian kinerja perbankan serta menjalankan prinsip ketatalaksanaan di bidang perbankan.
Analisis Kinerja Karyawan Sebelum dan Sesudah Reimplementasi System Application and Product pada Unit Bisnis Sera Group Makassar
Authors: Kartini  , Anshar Muh. Ashary 
Published: September 2022

Penelitian ini bertujuan untuk menganalisis kinerja karyawan sebelum dan sesudah penerapan reimplementasi system application and product pada unit bisnis Sera Group Makassar. Jenis penelitian ini adalah pendekatan kualitatif dengan metode penelitian menggunakan teknik fenomenologi. Hasil penelitian menunjukkan bahwa berdasarkan hasil wawancara bahwa kinerja karyawan dengan indikator kualitas, ketepatan waktu dan kemandirian sudah membaik setelah adanya reimplementasi SAP pada unit bisnis Sera Group Makassar.
Penerapan Teknik Motion Graphic pada Karya Air Magazine "Zero Waste is the New Taste"
Authors: Efiyanti Bella Meillenia , Astuti Aprilina Dwi 
Published: September 2022

Karya Air Magazine “Zero Waste is The New Taste” merupakan karya produksi audio visual yang membahas mengenai gaya hidup zero waste atau bebas sampah. Banyak faktor yang mendukung pembuatan sebuah produksi supaya menarik minat penonton. Diantaranya adalah penerapan motion graphic yang dapat mewarnai sebuah karya produksi sehingga menghasilkan visual yang informatif, khas, dan memiliki nilai estetika. Motion graphic juga dapat memperjelas informasi yang disampaikan kepada penonton. Tujuan dari penciptaan karya ini adalah menerapkan motion graphic pada program produksi audio visual dengan format air magazine berjudul “Zero Waste is The New Taste”. Metode penciptaan karya dilakukan melalui tiga tahap yaitu tahap pra produksi, produksi dan paska produksi. Teknik motion graphic yang diimplementasikan pada pembuatan karya ini adalah teknik animation graphic ,motion tracking dan teknik motion graphic compositing. Hasil dari karya produksi ini merupakan animation graphic menciptakan pergerakan gambar yang dinamis dan estetik diterapkan menggunakan transform tools seperti size dan position Untuk membuat looks stop-motion dapat digunakan effects posterize time dan toggle hold keyframe, lalu menggunakan keyframe assistant easy ease untuk membuat looks yang dinamis. Teknik motion tracking diterapkan dengan menggunakan tools Tracker pada footage vid
Accuracy of Revised Tokuhashi Scoring System and Prognostic Factors to Predict Life Expectancy in Lung Cancer Patients with Spinal Metastasis
Authors: Choovongkomol, MD Kongtush , Sirisopikun, MD Veerapat , Piyapromdee, MD Urawit , Tanaviriyachai, MD Terdpong , Jongkittanakul, MD Sarut 
Published: September 2022

Purpose: This study aimed to verify the accuracy of the revised Tokuhashi scoring system to identify the prognosis and life expectancy of lung cancer patients with spinal metastasis. We also aimed to find the factors that were related to the prognosis and actual death.
Method: Lung cancer patients with spinal metastasis who were diagnosed between January 2014 to December 2018 were included in this study. Demographic data, radiographic data, revised Tokuhashi score parameters, actual death, and treatment administered were collected from the hospital tumor database. The relationship between each parameter and actual death were collected and multivariable logistic regression analysis was used to explore the associated factors.
Results: Totally 181 patients were included in this study. The accuracy of the revised Tokuhashi scoring system in this study was 80.68% for scores 0-8 and 100% for scores ≥ 9. Sensitivity and specificity were 100%and 80.7%, respectively, for the prediction of life expectancy ≥ 6 months. LR+ was 5.18. Female (HR=0.58, P=0.001), good general condition (HR=0.34, P=0.036), none of extra spinal foci metastasis (HR=0.40, P=0.002), 1 or 2 extra spinal foci metastasis (HR=0.54, P=0.003), radiation (HR=0.57, P=0.02), and chemotherapy (HR=0.51, P=0.004) were the associated factors with statistical significance.
Conclusion: The revised Tokuhashi scoring system for lung cancer with spinal metastasis had satisfactory accuracy rate to predict life expectancy, especially for > 6 months (score ≥ 9). We also found that females, good general condition, number of extra spinal foci < 3, radiation, and chemotherapy were significantly good prognoses for life expectancy.
Dvojí výjimečnost z pohledu zahraničních studií
Authors: Baranová Petra , Márová Ivana , Kachlík Petr 
Published: September 2022

Předkládaný příspěvek se zabývá fenoménem dvojí výjimečnosti, v případě tohoto článku tedy kombinací vysokého nadání a specifických poruch učení. Cílem práce bylo analyzovat současné zahraniční studie, které se zabývají identifikací a diagnostikou kognitivně nadaných žáků se specifickými poruchami učení v období povinné školní docházky. Pro tyto účely bylo analyzováno 10 zahraničních studií, které se dvojí výjimečností zabývaly v letech 2010–2019. Ve výkladové části práce přibližuje cílovou skupinu žáků s dvojí výjimečností a pojednává o vývoji přístupů k dané problematice. Dále je pozornost věnována charakteristice žáků s dvojí výjimečností v edukačním prostředí a diagnostice dvojí výjimečnosti. V části analytické je práce zaměřena především na kombinace kognitivního nadání a specifických poruch učení ve vybraných studiích a nástroje, které byly pro účely identifikace a diagnostiky dvojí výjimečnosti ve vybraných studiích použity. Závěry předkládaného příspěvku ukazují, že diagnostický proces dvojí výjimečností není jednotný. Diagnostika dvojí výjimečnosti aktuálně sestává z nezávislé diagnostiky nadání a diagnostiky specifických poruch učení, přičemž pro každou oblast může být použita široká škála diagnostických nástrojů. Výkon žáka v jednotlivých testech je ovlivněn kombinací posílených dovedností a schopností pramenících z nadání a oslabených oblastí plynoucích ze specifických poruch učení. To má za následek rozdílnou úspěšnost v identifikaci žáka s dvojí výjimečností, a to jak v závislosti na použité kombinaci diagnostických nástrojů, tak také na kombinaci nadání a oslabených funkcí. Kognitivně nadaný žák je totiž schopen využívat své dovednosti k maskování či kompenzování oslabených funkcí, jeho výsledky v rámci diagnostiky proto mohou být neprůkazné. Pro účely včasné identifikace dvojí výjimečnosti jsou diskutovány modely určené pro včasné odhalení žáků v riziku školního neúspěchu v zahraničí, konkrétně RtI model a Model diskrepance. Z analýzy ovšem vyplývá, že pro účely včasného odhalení dvojí výjimečnosti je nezbytná jejich adaptace tak, aby reflektovaly unikátní kognitivní profil žáků s dvojí výjimečností.
The embodiment of the dialogue-polemic of A. Zhid with F.M. Dostoevsky and F. Nietzsche in the artistic space of the story "The Immoralist"
Authors: Glazkova Marina Mikhailovna 
Published: September 2022

The object of the study was the work of A. Zhid "The Immoralist" (1902). The work reveals and analyzes the originality of the artistic thought of the French writer, which manifests itself through an oxymoronic combination of the concepts of two philosophers-thinkers – F.M. Dostoevsky and F. Nietzsche. The reading of the work of A. Zhid in the context of a kind of dialogue is used. On the one hand, it is a dialogue with F. Nietzsche, with his idea of the role of a superman who takes the place of God in a world where "God died". On the other hand, with F. M. Dostoevsky, for whom the gospel truths remain indisputable. At the same time, it is a dialogue between F.M. Dostoevsky and F. Nietzsche in the artistic space of the work of the French writer. It is determined that the dialogue, carried out in a kind of triangle, reveals the main moral and philosophical problems of the "Immoralist" – the clash of Christian morality and Nietzschean absolute freedom. The scientific novelty lies in the fact that the analysis of the little-studied work of A. Zhid "Immoralist" was carried out in the parameters of an exclusive dialogue-polemic with radically opposite thinkers, F. Dostoevsky and F. Nietzsche, who significantly influenced the spiritual climate of the twentieth century. A. The Jew combines two opposing concepts in one artistic space, but no one wins in this struggle. F. Nietzsche and Dostoevsky reinforce the peculiar disturbing reflections of A. Zhid about the moral conflicts of the modern world. The work comprehends a number of general issues essential for the study of the history of literature, in particular, these are questions of philosophy, religion, morality.
CAV1 alleviated CaOx stones formation via suppressing autophagy-dependent ferroptosis
Authors: Yang Yuanyuan , Hong Senyuan , Lu Yuchao , Wang Qing , Wang Shaogang , Xun Yang 
Published: September 2022

Background
Calcium oxalate (CaOx) is the most common type of kidney stone, but the mechanism of CaOx stones formation remains unclear. The injury of renal cells such as ferroptosis and autophagy has been considered a basis for stones formation.

Methods
We conducted transmission electron microscope (TEM), reactive oxygen species (ROS), malondialdehyde (MDA), glutathione (GSH), and C11-BODIPY analysis to explore whether CaOx could induce autophagy-dependent ferroptosis in vivo and in vitro. To explore the possible mechanism, we conducted bioinformatic analysis of patients with or without CaOx stones, Western blot and qPCR were used to identify the different genes we found in bioinformatic analysis.

Results
In our study, we found that CaOx could induce autophagy-dependent ferroptosis no matter in vivo or in vitro, which might finally lead to urolithiasis. Bioinformatic analysis of the GSE73680 dataset indicated that the expression of caveolin-1 (CAV1) was higher in control patients than CaOx stone patients, the STRING database indicated that CAV1 might interact with low density lipoprotein receptro-related protein 6 (LRP6), Gene Set Enrichment Analysis (GSEA) showed that the WNT pathway positively associated with the control group while negatively related to the stone group, and LRP6 was the core gene of the WNT pathway. Western blot found that CAV1, LRP6, and Wnt/β-Catenin were decreased in Human Kidney2 (HK2) cells stimulated with CaOx. Furthermore, the WNT pathway was considered to be involved in autophagy and ferroptosis.

Conclusions
We presumed that CAV1 could ameliorate autophagy-dependent ferroptosis through the LRP6/Wnt/β-Catenin axis, and finally alleviate CaOx stone formation.
The AI field needs translational Ethical AI research
Authors: Schaich Borg Jana 
Published: September 2022

AbstractCalls for Ethical AI have become urgent and pervasive, especially as ethical issues surrounding AI products at tech companies are increasingly scrutinized by the public. Yet even after a first wave of responses to these calls coalesced around Ethical AI principles to guide decision‐making and a second wave generated technical tools to mitigate specific ethical issues, multiple lines of evidence indicate that these Ethical AI principles and technical tools have only a limited impact on the daily practices of AI users and producers. In other words, there is a big gap between what we publish in academic papers and what AI creators need to generate AI products that reflect society's values. Ethical AI is by no means the only field to have this problem. However, when medical and ecology fields documented similar gaps between their fields’ scientific discoveries and the practices and products that people actually use, they invested tremendous resources into subfields that developed evidence about how to translate what was done in the lab to adopted solutions. I argue in this commentary that it is our research community's moral duty to invest in our own subfield of “Translational Ethical AI” that will determine how best to ensure AI practitioners can implement the Ethical AI technical tools we publish in academic venues in production settings. Further, I offer concrete steps for doing that, drawing on insights gleaned from other translational fields. Closing the “Ethical AI Publication‐to‐Practice gap” will be a considerable transdisciplinary challenge, but one of the AI research community has the unique expertise, political leverage, and moral responsibility to tackle.
A Honeycomb‐Like Porous Crystalline Hetero‐Electrocatalyst for Efficient Electrocatalytic CO2 Reduction
Authors: Yang Yi‐Lu , Wang Yi‐Rong , Dong Long‐Zhang , Li Qi , Zhang Lei , Zhou Jie , Sun Sheng‐Nan , Ding Hui‐Min , Chen Yifa , Li Shun‐Li , Lan Ya‐Qian 
Published: September 2022

AbstractPorous heterostructured electrocatalysts with multifunctionality and synergistic effect have much benefit for efficient electrocatalytic CO2 reduction reaction (CO2RR), yet it still remains a daunting challenge to explore heterostructures based on covalent organic frameworks (COFs) and metal–organic frameworks (MOFs) in this field. Here, a series of honeycomb‐like porous crystalline hetero‐electrocatalysts (MCH‐X, X = 1–4, X stands for the numbered sample obtained from different MOF doses in the synthesis of the MCH) are synthesized, and these are successfully applied in electrocatalytic CO2RR. The specially designed heterostructures with integrated porous MOF‐template and ultrathin COF‐coating enable efficient CO2 adsorption/activation and conversion into CH4. The best of them, MCH‐3, shows greatly inhibited H2 evolution, excellent current density (−398.1 mA cm−2), and superior (76.7%) to the physical mixture (38.0%), the MOF@COF without the honeycomb‐like morphology (47.7%), and the bare COF (37.5%) and MOF (15.9%) at −1.0 V. Based on the density functional theory calculations and various characterizations, the vital roles of the MOF in facilitating CO2 adsorption/activation, stabilizing intermediates, and conquering the energy barrier of rate‐determining step are intensively studied.
Silky dogwood (Swida amomum) seed dispersal by freshwater turtles
Authors: Padgett Donald J. , Gouthro Alexis , Adams Michelle , Surasinghe Thilina D. 
Published: September 2022

AbstractPremiseEffective seed dispersal is essential to the success of plant species. Swida amomum (silky dogwood) has a seed‐dispersal syndrome characteristic of autumn‐ripening shrubs with fleshy fruits; attached fruits are ingested and defecated by birds, while fallen fruits are consumed by ground‐foraging birds and mammals.MethodsWe documented that fallen fruits of this shrub were consumed by two aquatic turtle species (eastern painted turtle [Chrysemys picta] and red‐eared slider [Trachemys scripta]) and that their seeds were defecated. We compared germination success (percentage of seeds germinated) of defecated seeds, seeds collected from a pond surface, and seeds removed from shrubs.ResultsWhile four seed species were identified in fecal samples, seeds of S. amomum were the most frequent (93%) among samples and the most numerous (106 seeds) in any sample. Average proportion of fecal seeds germinated (85.99%) exceeded that of seeds from the pond surface (82.76%) and from shrubs (60.24%), albeit the difference in germination success was insignificant. When analyzed using fecal samples from painted turtles only, the difference in germination success between fecal seeds and those collected from pond or shrub became significant.ConclusionsOur findings represent the first report of S. amomum seeds being dispersed by turtle gut passage and suggest aquatic turtles could be an important part of a secondary seed dispersal process influencing woody plant community composition in temperate wetland ecosystems.
Locations of seed abortion in response to defoliation differ with pollen source in a native perennial legume herb
Authors: Cardel Yuria J. , Koptur Suzanne 
Published: September 2022

AbstractPremiseIn many flowering plants, flowers contain more ovules than fruits have seeds. What determines which ovules become seeds? When photosynthates are limited, as may happen when plants lose leaf area to herbivory, fewer fertilized ovules become seeds.MethodsGreenhouse‐grown ramets of distinct individuals of a perennial herbaceous legume were manually defoliated to various levels determined in the field, then self‐ or cross‐pollinated. For each seed produced, we recorded its position in the fruit and its mass. From a subset of seeds from different treatments and positions in the fruits, we grew seedlings and measured their dry mass.ResultsOvules were aborted more frequently in fruits from flowers that were self‐pollinated and from those on plants with higher levels of defoliation. Ovules in the basal portion of the fruits were more likely to be aborted than those at the stigmatic end; this pattern was most pronounced for fruits after self‐pollination with high levels of defoliation. Total number of seeds produced and seed mass per pod were greatest in cross‐pollinated fruits after no or low levels of defoliation. Mean individual seed mass was greater for fruits with fewer seeds, indicating a trade‐off between seed number and seed mass. Seedling dry mass (a measure of vigor) was greatest for seeds in the middle positions of fruit produced by cross‐pollination after severe herbivory; no positional differences were seen for seeds from self‐pollinated fruits.ConclusionsObserved locations of seed abortion may have been selected not only by defoliation, but in part by propensity for dispersal, while positional differences in seedling vigor may be related to seed size and differential maternal allocation based on pollination treatment and leaf area lost.
Heterozygous Seryl‐tRNA Synthetase 1 Variants Cause Charcot–Marie–Tooth Disease
Authors: He Jin , Liu Xiao‐Xuan , Ma Ming‐Ming , Lin Jing‐Jing , Fu Jun , Chen Yi‐Kun , Xu Guo‐Rong , Xu Liu‐Qing , Fu Zhi‐Fei , Xu Dan , Chen Wen‐Feng , Cao Chun‐Yan , Shi Yan , Zeng Yi‐Heng , Zhang Jing , Chen Xiao‐Chun , Zhang Ru‐Xu , Wang Ning , Kennerson Marina , Fan Dong‐Sheng , Chen Wan‐Jin 
Published: September 2022

ObjectiveDespite the increasing number of genes associated with Charcot–Marie‐Tooth (CMT) disease, many patients currently still lack appropriate genetic diagnosis for this disease. Autosomal dominant mutations in aminoacyl‐tRNA synthetases (ARSs) have been implicated in CMT. Here, we describe causal missense mutations in the gene encoding seryl‐tRNA synthetase 1 (SerRS) for 3 families affected with CMT.MethodsWhole‐exome sequencing was performed in 16 patients and 14 unaffected members of 3 unrelated families. The functional impact of the genetic variants identified was investigated using bioinformatic prediction tools and confirmed using cellular and biochemical assays.ResultsCombined linkage analysis for the 3 families revealed significant linkage (Zmax LOD = 6.9) between the genomic co‐ordinates on chromosome 1: 108681600–110300504. Within the linkage region, heterozygous SerRS missense variants segregated with the clinical phenotype in the 3 families. The mutant SerRS proteins exhibited reduced aminoacylation activity and abnormal SerRS dimerization, which suggests the impairment of total protein synthesis and induction of eIF2α phosphorylation.InterpretationOur findings suggest the heterozygous SerRS variants identified represent a novel cause for autosomal dominant CMT. Mutant SerRS proteins are known to impact various molecular and cellular functions. Our findings provide significant advances on the current understanding of the molecular mechanisms associated with ARS‐related CMT. ANN NEUROL 2023;93:244–256