bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward the clinical application of the Child Psychosis-Risk Screening System (CPSS)
Authors: Hamasaki Y. , Matsuo M. , Sakaue Y. , Sanada R. , Nakayama T. , Michikoshi S. , Ueba S. , Kurimoto N. , Hikida T. 
Published: September 2022

IntroductionIn our previous study, we have developed the Child Psychosis-risk Screening System (CPSS), which incorporates psychological and behavioral characteristics of childhood into an algorithm, based on a retrospective survey.ObjectivesIn this study, we actually tried to evaluate the risk of psychosis in pediatric and psychiatric outpatients using the CPSS.MethodsWe conducted an epidemiological study of 323 outpatients aged 6-18 years visiting pediatric and psychiatric departments using CBCL and clinical data (sex, age, winter birth, chief complaint, diagnosis, abuse, bullying, hikikomori). ROC analysis was used to assess the accuracy of CPSS predictions. Cross-sectional logistic regression analysis was performed on the clinical data to identify factors associated with risk groups exceeding the cutoff value.ResultsThe results of the ROC analysis showed that the AUC (Area under the ROC Curve) was 80.3%, indicating that the CPSS has Moderate accuracy. The cutoff value was 98.11% (sensitivity: 0.857, specificity: 0.835), and 18% of the subjects were identified as risk groups above this value. Cross-sectional logistic regression analysis showed that schizophrenia diagnosis, no abuse, winter birth, and hikikomori were associated with the risk group, with respective odds ratios of 22.88, 10.76, 1.91, and 1.37.ConclusionsThe results of this study suggest that the CPSS can be applied to pediatric practice for early detection of risk for psychosis. The risk group is also present among pediatric patients with physical chief complaints. The factors suggested to be associated with risk groups may reflect the factors acting on the critical period of psychosis onset and the dynamic state.DisclosureNo significant relationships.
Upside down: dissecting impulsivity in attention-deficit hyperactivity disorder through genotype-phenotype association analyses
Authors: Balogh L. , Pulay A. , Angyal N. , Vincze K. , Kilencz T. , Nemoda Z. , Réthelyi J. 
Published: September 2022

IntroductionBetter evaluation and understanding of the core symptoms have key importance both in clinical practice and the research of attention-deficit hyperactivity disorder (ADHD). One hallmark neurocognitive feature of ADHD is impaired inhibition, related to impulsivity. Given the high heritability of ADHD, the assessment of genetic background of impaired inhibition may contribute to our knowledge about the genetic background of the disorder.ObjectivesIn our study we investigated whether different forms of impulsivity (attentive, motor, and nonplanning) and polymorphisms in genes of the noradrenergic, serotonergic, and dopaminergic neurotransmission, i.e. dopamine transporter-1 (DAT1), cathecoloamin-O-metiltransferase (COMT), and serotonin receptor-1B (HTR1B genes show association.Methods208 aADHD patients diagnosed according to DSM-5 criteria from a clinical sample and 142 individuals from a population sample who screened positive for aADHD were included in the study. DNA samples were genotyped for the HTR-1B gene rs1321041 and the COMT gene rs4680 SNPs, moreover the DAT-1 VNTR polymorphism. Dimensional variables for impulsivity were compared between genotypes with the Generalized Linear Model procedure corrected for sex and age, using the PLINK 1.9 statistical software.ResultsThe 9 repeat polymorphism in DAT1 was associated with the severity of hyperactivity, moreover, all impulsivity factors. The A allele in COMT was associated with hyperactivity and better motor inhibition activity. In carriers of the G allele in HTR1B we detected significantly higher inattention scores and increased reaction time.ConclusionsOur results support the putative role of the investigated genetic polymorphisms in the etiology of impulsivity. Nevertheless, these polymorphisms demonstrate a heterogeneous associations.DisclosureNo significant relationships.
Being a psychiatric resident during COVID times – personal experiences of Hungarian trainees
Authors: Asbóth C. , Gergics E. , Gurzó S. , Herczeg A. , Hrapcsák A. , Kupcsik F. , Nagy P. , Oláh O. , Szilvágyi G. , Szocsics P. , Szűcs Z. , Bitter I. 
Published: September 2022

IntroductionDuring the COVID-19 pandemic residents of the central region of Hungary also had to adapt to several challenges such as changes of hospitals’ specialty profiles and delegation of health care workers to COVID wards.Hungarian residents have their practical training in various hospitals, while their psychiatric academic training is organised in groups.ObjectivesOur aim is to share our personal experiences about how our work and training have changed during the pandemic and it’s effect on our patients.MethodsParticipants of the study were the authors of the poster. Responses to open questions were structured based on the following topics: competencies in internal medicine, infectious diseases and psychiatry, our collaboration with other medical disciplines, psychiatric training and attitudes towards mental health patients.ResultsWe worked min 2 weeks max 8 months at COVID wards and also treated COVID-19 infected psychiatric patients, thus gaining a greater experience in general medicine. In psychiatric work, acute care became prominent, communication in PPE and restricted contact with patients’ relatives were particularly difficult. Our relationship with other specialists has improved, consultation became easier. Increased use and misuse of psychiatric consultation requests led to further pressure. Restrictions, stigmatisation and discrimination increased against psychiatric patients, including difficult access to care. Psychiatric training in the hospitals became limited, however seminars organized by the university continued online with our active participation.ConclusionsDuring the pandemic we gained greater experience in general medicine. Psychiatric care and our training was negatively affected, however the latter was mitigated by online seminars.DisclosureNo significant relationships.
Assessing the feasibility of MOVING FORWARD, a multicentre transition intervention model across adolescent secure services in England: A cluster randomised feasibility trial
Authors: Livanou M. , Lane R. 
Published: September 2022

IntroductionYoung people moving from adolescent secure inpatient units to adult care in the UK present with multiple and complex needs and are more likely to experience poor transition outcomes related to enduring dependency on mental health services. However, there is lack of knowledge about the feasibility of transitional care models improving transition outcomes.ObjectivesThe MOVING FORWARD study aims to implement a new transition intervention model for young people transitioning from adolescent secure services to adult-oriented settings and test the feasibility of a future cluster trial measuring its effectiveness.MethodsThe design of the study is a three-arm feasibility, cluster randomised controlled trial comparing the MOVING FORWARD intervention against standard transition preparation in six adolescent secure services.Young people between 17-19 years, their parents/carers and key workers will be allocated in two conditions and will receive four transition preparation workshops across six months. Data will be collected at three time points: (T0) baseline, (T1) 6-12 months post-intervention, and (T2)18-24 months post-baseline.ResultsThirteen young people and 17 staff members have contributed to the intervention design through online Advisory Groups. Common identified themes included appropriateness of module content and support during delayed transitions. An intra-class correlation coefficient will be calculated to inform the power of sample size. With a sample size of 50, we will be able to estimate a drop-out rate of 80%.ConclusionsThis research will provide practitioners and policy makers with an evidence-based framework about barriers and facilitators to the proposed intervention and will enable services to reflect on quality of transitional care delivery.DisclosureNo significant relationships.
How mothers of terminally ill children cope and appraise their life situation
Authors: Bityutskaya E. , Lebedeva N. 
Published: September 2022

IntroductionMothers of terminally ill children experience chronic stress that can lead to physical and emotional exhaustion. A better understanding of their experiences, resources, and vulnerabilities can help plan psychological interventions.ObjectivesThe research is aimed to study mothers’ appraisals of their life situation related to the child’s terminal illness and their coping strategies.MethodsParticipants: 21 women (aged 26-49) whose children were patients at the hospice. Women answered a set of open-ended questions and completed questionnaires: “Appraisal Criteria of the Difficulty of a Life Situation”, “Types of Orientations in Difficult Situation”, “Ways of Coping Checklist”. Data were analyzed with Pearson’s r.ResultsPlanned coping was associated with evaluations of opportunity (r=0.78) and threat to the future (r=0.61). Despite the deteriorating health status of most of the children, women reported a high degree of subjective control. This might be related to outside help. Participants stated that helping by the family, doctors, and psychologists was essential. Unexpectedly, the “need for a quick and active response” score correlates with that for the coping strategy “fantasizing” (r=0.62). This can be explained by the depletion of resources; deprivation of sleep and active rest is often observed. An important feature is that half of the participants report high self-blame.ConclusionsWe suggest that self-blame, an analysis of opportunities, and probable future scenarios are important psychotherapy targets for mothers of terminally ill children. The consequences of threat appraisal are twofold: admitting the threat can be painful, but it also mobilizes one’s energy. Funding: The study was funded by RFBR, project number 20-013-00838.DisclosureNo significant relationships.
Clozapine placental passage at delivery: an update
Authors: Imaz M.L. , Lera S. , Roda E. , Roca A. , Torres A. , Solé E. , Andres S. , Mallorquí A. , Garcia-Esteve L. 
Published: September 2022

IntroductionClozapine is an effective second-generation antipsychotic that is approved for treatment-resistant schizophrenia and risk reduction of recurrent suicidal behavior in schizophrenia or schizoaffective disorder. Its available pregnancy pharmacikinetics data remain limited, which presents a challenge for clinicians managing women taking clozapine during perinatal period .ObjectivesThe aim of this study was to provide new data of clozapine and norclozapine placental passage and neonatal outcomes.MethodsWe retrospectively studied a consecutive case series of six pregnancies where there was clozapine exposure (5 in politherapy and 1 in monotherapy). Clozapine and norclozapine serum concentrations were determined in the mother-infant pairs on the day of delivery (intrapartum maternal blood and umbilical cord blood respectively) and measured using a validated high-performance liquid chromatography method. The within- and between-day precision expressed as the coefficient of variation (CV)% were both <10%. The limit of quantification (LoQ) was 5 ng/mL. Neonatal outcomes were reviewed from pediatric records.ResultsThe mean infant-mother clozapine and norclozapine ratio at delivery were 0.44 (SD=0.13) and 0.28 (SD=0.05) respectively. There was a weak positive correlation between maternal and umbilical cord clozapine and norclozapine serum concentratios (Pearson correlation coefficient 0.183, p=0.769 and 0.827, p=0.084 respectively). The rate of neonatal complications was 16%. One neonate (16%) , whose mother had drug abuse history during pregnancy, presented with a generalized neurodevelopment delay and the consequent need for continuous intensive care.ConclusionsIn our study, placental passage of clozapine and norclozapine was partial during delivery. Statistical power was limited for examining te association between neonatal clozapine levels and neonatal outcomes.DisclosureNo significant relationships.
The Portuguese adapted version of the fear of covid-19 scale for the postpartum period
Authors: Pereira D. , Pereira A.T. , Wildenberg B. , Gaspar A. , Cabacos C. , Madeira N. , Macedo A. 
Published: September 2022

IntroductionThe Portuguese version of the Fear of COVID-19 Scale (FCV-19S; Cabaços et al. 2021), composed of seven items, presented good validity and reliability to be used in general population. To be used within perinatal context, specifically in the postpartum period, we have added an item related to the baby (item 8 – “I’m afraid my baby will be infected with coronavirus-19”).ObjectivesTo analyze the psychometric properties of Portuguese adapted version of the Fear of COVID-19 Scale for the postpartum period (FCV-19SP), namely construct validity, internal consistency, and convergent validity.Methods207 women (mean age= 33.51 ± 5.23 years) recruited in the postpartum period (9,06 ± 8,52 months after delivery) fill in a set of self-reported validated questionnaires: Perinatal Depression Screening Scale (PDSS), Perinatal Anxiety Screening Scale (PASS) and Coronavirus-19 Fear Scale for the postpartum period (FCV-19SP).ResultsCFA revealed that the unifactorial model composed of eight items presented good fit indexes (X2/df=1.508; CFI=.991; GFI=.974; TLI=.983; p[RMSEA≤.01] = .049), better than those of the seven items version (X2/df=3.963; CFI=.957; GFI=.909; TLI=.905; p[RMSEA≤.01] =.219). Cronbach alpha for the FCV-19SPP was α=.880. The total score significantly (p<.01) and moderately correlated with PDSS (r=.262) and PASS (r=.371).ConclusionsThe FCV-19SP is a valid and reliable questionnaire to assess fear of COVID-19 in women in the postpartum period.DisclosureNo significant relationships.
Art therapy focused on stimulating the emotional and expressive skills of the atypical children
Authors: Hosu L.-M. 
Published: September 2022

IntroductionThe role of the art therapist can be to identify the creative potential, to value it and to support social integration through art. Detecting and developing the outstanding and hidden abilities of the atypical child can lead to a normal behavior and to a better social integration.ObjectivesIncreasing self-esteem, through personal satisfaction, emotional development and the development of hidden and outstanding skills.MethodsStimulating the child through the environment, works as a non-directive method during the art therapy session. Work environments offer various possibilities of expression, he chooses the materials to which he shows an interest, developing his own technique over time.The child is encouraged during the art therapy sessions, by exhibiting the works and decorating the work environment.Through these non-directive methods, the evolution of visual thinking is accelerated. The chromatic diversification, the gestures in painting and the alternation of work techniques such as printing, graphic lines and dripping, are signs of a visual thinking. The child discovers the environment and interacts with it trough art.Observing the potential of the materials around him and also certains physical phenomena, such as a three-dimensional mask that allows the color to outline its volumes by draining it on the shape, the child uses consciously the properties of materials and the movement of the object.ResultsDiscovering artistic and decorative skills; Increased self-esteem; Interaction in the artistic environment and even verbal communication in cases of autism.ConclusionsThrough art, the child can get closer to the social life.DisclosureNo significant relationships.
First case of new-onset psychosis due to DBS in the ventralis intermediate nucleus (Vim) of the thalamus
Authors: Petrykiv S. , Arts M. , De Jonge L. 
Published: September 2022

IntroductionKnown risk factors for developing of first-time psychosis in patients with deep brain stimulator (DBS) include older age, short time after implant placement and cerebral target for stimulation. In particular, stimulation of subtalamic nucleus and globus pallidus internus has been shown to elicit psychotic symptoms in various case reports. To date, there are no cases describing onset of psychosis due to DBS in the ventralis intermediate nucleus (Vim) of the thalamus.ObjectivesCase describtion of psychotic episode provoked by DBS in Vim regionMethodsCase report of 70 y.o. female with unilateral DBS from 2012 in Vim for essential tremor, who developed therapy resistant psychotic symptoms right after adjusted settings of the DBS.ResultsPsychotic onset of otherwise healthy 70 y.o. patient occurred and gradually worsened after adjustment of DBS settings in absence of other iatrogenic factors, including medication and comorbidity, and required involuntary hospitalization one week after beginning of psychosis. Treatment after hospitalization comprised olanzapine 10 mg. 1dd1 did not cause resolvent of psychosis. Because of therapy resistance to psychofarmaca and worsening of psychotic symptoms, by way of exception neurologists had to change the settings back to basic leading to complete and sustained remission of psychosis within two days.ConclusionsAmong side effects of DBS in Vim, psychotic symptoms have never been reported. However, as in our patient, psychosis occurred after changes of settings in DBS and presented acutely, was severe, resulted in involuntary hospitalization and was therapy resistant. Pathophysiology of DBS-induced psychosis in Vim region is not known and requires further investigation.DisclosureNo significant relationships.
Low level of perfectionism as a possible risk factor for suicide in adolescents with attention-deficit/hyperactivity disorder
Authors: Katzenmajer-Pump L. , Farkas B. , Varga B. , Jansma J. , Balazs J. 
Published: September 2022

IntroductionPrevious research highlighted that adolescents with attention-deficit/hyperactivity disorder (ADHD) are four times as vulnerable to suicidal behavior as the healthy population. Maladaptive perfectionism is also viewed as an important risk factor for suicide. Yet, there are no studies which focused on the relationship between perfectionism and suicide among adolescents with ADHD.ObjectivesThe objective of the present study was to explore if perfectionism may be a risk factor for suicidal behavior in adolescents with ADHD.MethodsThe clinical group was recruited from outpatient clinics, while the non-clinical group was recruited from high schools around Hungary. The clinical group’s inclusion criterion was ADHD diagnoses, while the non-clinical group required the absence of any current or past psychiatric treatment or diagnoses.ResultsIn the ADHD group 88 adolescents participated, and 96 adolescents participated in the non-clinical group. There was no difference regarding the level of perfectionism in the groups, except one dimension of perfectionism, which is ‘Organization’. The ADHD group had significantly higher level of suicidal behavior than the control group ((χ2 (1) = 11.222, p < .001, V = 0.25). Among the ADHD group adaptive perfectionism was significantly negatively correlated with suicidal behaviour.ConclusionsAdolescents with ADHD did not have a different level of perfectionism than the healthy control group only in ‘Organization’ trait. This result could add to the therapeutic work with adolescents diagnosed with ADHD with underlining the importance to focus on organizational skills. The result highlights that adaptive perfectionism appears to be a protective factor against suicidality.DisclosureNo significant relationships.
Retrospective Chart Review of Patients with Self-Harm Seen as Liaison Psychiatry in Pakistan
Authors: Malik M.F.A. , Najeeb B. 
Published: September 2022

IntroductionSelf‑harm is an ‘act of self‑poisoning or self‑injury carried out by a person, irrespective of their motivation’. A history of self-harm is linked with suicide risk. A study in Pakistan found self-harm to be more common in young people with unemployment and interpersonal difficulties as common triggers. Expanding liaison psychiatry services leads to an earlier assessment of patients with self-harm.ObjectivesTo study the demographic and clinical variables of patients along with methods and precipitating factors of self-harm.MethodsA retrospective chart review of patients presenting with self-harm seen as a part of liaison psychiatry from October 2018 to June 2021.ResultsA total of 168 cases were seen of which 10 were excluded due to incomplete data. Of 158 cases gender split was roughly in the middle, with 49.4% males (n=78) and 50.6% females (n=80). The mean age of patients was 27.59 with a range of 12-70, 40.5% belonged to the age group of 20-29 (n=64) (Figure 1).77.8% (n=123) had a past psychiatric history. The most common being depressive disorder 31.6% (n=50) and borderline personality disorder 30.4% (n=48). 35.4% of patients reportedly had previous attempts of self-harm. The most common methods being the use of sharp objects, rat-pill poisoning, and corrosive intake (Figure 2).Conflicts with family and relationship difficulties were reported to be the most common precipitating factors.ConclusionsSelf-harm is a challenging and frequent presentation. Patients may present with diverse characteristics and varying needs. Hence physicians must be prepared for timely liaison and prompt management.DisclosureNo significant relationships.
Reflections, impact and recommendations of a co-produced ecological momentary assessment (EMA) study with young people who have experience of suicidality and psychiatric inpatient care
Authors: Dewa L. , Pappa S. , Mitchell L. , Hadley M. , Cooke J. , Aylin P. 
Published: September 2022

IntroductionPatient and public involvement (PPI) in suicide research is ethical, moral and can deliver impact. However, inconsistent reporting of meaningful PPI, and hesitancy in sharing power with people with experience of suicidality (i.e.co-researchers) in research makes it difficult to understand the full potential impact of PPI on the research, researchers and co-researchers.ObjectivesTo describe how our ecological momentary assessment (EMA) study, examining the sleep-suicide relationship in young psychiatric inpatients (aged 18-35) transitioning to the community, has been co-produced, whilst reflecting on impact, challenges, and recommendations.MethodsWe built on our experience of co-produced mental health research to conduct meaningful PPI in our study. Young adults with experience of psychiatric inpatient care and suicidality were appointed November 2020 to work across all research stages. Reflections on challenges, recommendations and impact have been collected throughout.ResultsThree young people became co-researchers. Researcher and co-researcher reflections indicated establishing and maintaining safe environments for open discussion, and continued communication (e.g.WhatsApp group) were vital to effectively share power and decision making. Safeguarding and support requirements for both co-researchers (e.g.individualised strategy) and researcher (e.g.clinical supervision) were particularly evident. To date, the co-produced recruitment poster, research documentation, and research article have demonstrated significant impact.ConclusionsThis is the first EMA study focused on suicide-sleep during transitions to be co-produced with young people with experience of suicidality. Co-producing suicide research is intensive, time-consuming, and challenging but makes a significant impact to the research, researchers, and co-researchers. We expect our learning will directly influence, and help others produce, meaningful co-produced suicide research.DisclosureNo significant relationships.