bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manajemen Sumber Daya Budaya sebagai Dasar Pengembangan Pariwisata di Maluku
Authors: Ririmasse Marlon NR 
Published: March 2022

Bulan Agustus 2007 Balai Arkeologi Ambon kembali mengadakan Pameran dan Diskusi Arkeologi Tahunan. Sebagaimana tahun sebelumnya, kegiatan ini dipusatkan di Kota Ambon, dan mengambil tema Pengelolaan Sumber Daya Budaya untuk Pengembangan Pariwisata Berbasis Kearifan Lokal. Makalah ini ditulis sebagai bagian kegiatan diskusi, yang bertujuan menciptakan ruang untuk menampung pemikiran lintas instansi di Maluku, yang diharapkan dapat didayagunakan untuk menciptakan suatu iklim pengelolaan sumber daya budaya, yang mampu memberi kontribusi signifikan bagi pengembangan pariwisata di Maluku.
Ustekinumab in the Treatment of Erythema Nodosum with Underlying Crohn’s Disease: A Case Report
Authors: Sanín-Guana Antonio , Lebwohl Mark 
Published: March 2022

Erythema nodosum (EN) is a septal panniculitis characterized by raised, tender, red or purple lesions with a diameter of 1-5 cm. It is commonly treated with corticosteroids and can be an extra-intestinal manifestation of Crohn’s disease (CD). CD can be treated with ustekinumab, a monoclonal antibody that targets the p-40 subunit of the interleukin-12 (IL-12) and interleukin-23 (IL-23). A 78-year-old woman with erythema nodosum and Crohn’s disease presented with multiple erythematous nodules, which had been recurring on both of her legs for decades. The patient had failed many traditional EN treatments and was prescribed off-label ustekinumab, resulting in resolution of EN. This finding suggests that ustekinumab may be a potential treatment for EN in patients who also have CD.
SARS-Cov-2 Infection Uncovering Latent Mycobacterium Leprae Infection
Authors: Mancuso Christopher , Reiter Paloma , Zambrano Regina , Saini Ritu , Sirota-Rozenberg Suzanne 
Published: March 2022

Leprosy is a chronic granulomatous infection caused by the bacteria Mycobacterium leprae. It can remain dormant in a patient without any symptoms until triggered by a stressor on the body. During the coronavirus disease 2019 (COVID-19) pandemic, a significant amount of emotional and psychological stress was endured by patients. In addition, many patients experienced exacerbations of their preexisting conditions. Few reports have described cases of leprosy with concurrent COVID-19. This brief article presents a case of newly diagnosed leprosy in a middle-aged male following a COVID-19 infection. To our knowledge, this is the first reported case of its kind in the United States.
Granulomatous Mastitis with Erythema Nodosum: A Case Report and Systematic Review
Authors: Ngonadi Nwanneoma , Florenzo Brian , Flowers Richard , Martin Seth 
Published: March 2022

A healthy G5P3 34-year-old Hispanic patient with a new diagnosis of granulomatous mastitis of the right breast was referred to the dermatology clinic for painful skin lesions that had enlarged over the week prior and arthralgia in her knees and elbows. Examination revealed multiple tender, erythematous subcutaneous nodules scattered over the extensor surfaces of bilateral upper and lower extremities. Histology from the right forearm exhibited a mixed septal and lobular panniculitis with acute neutrophilic inflammation with granulomatous changes, consistent with erythema nodosum. The patient experienced significant improvement with prednisone taper, but flared on discontinuation; methotrexate was started with stabilization of her disease.
Although once considered a rare association, GM associated with EN is increasingly recognized, and since 1987, a total of 28 reports have detailed 59 cases (including the present case). Here, we provide a comprehensive review of all 58 reported cases of this association, including ours. We found a preponderance of cases occurred in females of Turkish ancestry around the fourth decade of life in the peripartum period. Arthralgia is the most common additional symptom. The majority of cases responded to treatment with oral corticosteroids, but some required the addition of other immunosuppressants and/or definitive surgical excision.
Exploring the Psychosocial Impact on Parents of Adolescents Diagnosed With Hidradenitis Suppurativa: A Retrospective Claims-Based Analysis
Authors: Yang Jay , Kirby Joslyn , Maczuga Steven 
Published: March 2022

Background: Chronic conditions, such as hidradenitis suppurativa (HS), can have an immense impact on patient quality of life; however, less is known about the influence that these diseases may have on the parents of adolescent patients with HS. This study aims to investigate the significance of an HS diagnosis on an adolescent’s parents, including depression, anxiety, and changes in employment status. An understanding of this relationship can assist in both the prevention, screening, and treatment of mental health conditions in parents.
Methods: This retrospective cross-sectional analysis was conducted using data from the MarketScan Claims database. Data were collected for adolescents and their parents using a 3-year study period between 1/1/2015-12/31/2017; families with adolescents aged 11-17 years with HS and randomly selected age-/sex-matched adolescents without HS and their families (1:5 ratio) were used as controls, and a total of 20,568 families were included in this study. Claims of depression, anxiety, and employment status change in parents of adolescents with HS were compared against parents of adolescents without HS using regression analysis.
Results: The study population involved 20,568 families, including 3,428 families with HS (mean [SD] age of adolescent: 14.54 [1.70]) and 17,140 control families (mean [SD] age of adolescent: 14.35 [1.92]). The majority of adolescents in the study were female (81.7%). Parents of adolescents with HS experienced significantly higher rates of depression (21.53% vs. 19.57%, p = 0.009) than unaffected parents, as well as significantly higher rates of employment status change (6.30% vs 5.21%, p = 0.01).
Conclusions: Parents of adolescents with HS are more likely to experience depression and changes in employment status than unaffected parents. These results highlight the significant consequences that an HS diagnosis has on a family and underscore the need for further attention and resources for the mental health of these susceptible caregivers.
Delayed peritoneal shunt catheter migration into the pulmonary artery with indolent thrombosis: A case report and narrative review
Authors: Patel Mayur S. , Zhang Justin K. , Khan Ali Saif Raza , Alexopoulos Georgios , Khan Maheen Q. , Mercier Philippe J. , Kemp Joanna M. 
Published: March 2022

Background:
Ventriculoperitoneal (VP) shunts are the preferred surgical treatment for hydrocephalus, and rarely, these operations may be complicated by catheter migration to ectopic sites. We present the case of an asymptomatic VP shunt patient with delayed peritoneal catheter migration into the pulmonary artery shunt catheter migration into the pulmonary artery (SCMPA) complicated by knotting and indolent thrombosis, necessitating open-heart surgery for system retrieval.

Methods:
We conducted a literature review in PubMed, Scopus, and Web of Science of prior similar reported cases and present the results of 24 cases of SCMPA.

Results:
An asymptomatic 12-year-old male presented with SCMPA noted on routine annual follow-up imaging. Preoperative CT angiogram indicated extensive catheter looping into the pulmonary artery without evidence of thrombosis. Less invasive attempts to retrieve the retained catheter were unsuccessful, and open-heart surgery was required. Intraoperatively, a nonocclusive pulmonary arterial thrombus surrounding the knotted catheter was discovered that was lysed successfully before system retrieval.

Conclusion:
VP shunt catheter migration into the pulmonary artery (SCMPA) with concurrent large vessel thrombosis can develop in pediatric patients incidentally without any clinical symptoms. Our report suggests that preoperative CT angiogram may be insufficient to detect arterial thrombosis in the presence of extensive intravascular catheter knotting. An open-chest approach may be the only viable surgical option for catheter retrieval in the presence of complex catheter coiling. The use of anticoagulation following open-heart surgery for retrieval of a migrated VP shunt catheter remains unclear, we here propose that continuation of long-term therapeutic anticoagulation may successfully prevent thrombus relapse.
Distal migration of the flow-redirection endoluminal device immediately after treatment: A case report and literature review
Authors: Nariai Yasuhiko , Takigawa Tomoji , Hyodo Akio , Suzuki Kensuke 
Published: March 2022

Background:
A flow diverter (FD) has been a promising endovascular therapeutic modality for challenging intracranial aneurysms. However, stent migration has been an unusual complication. Until recently, among some types of FDs, the migration of the flow-redirection endoluminal device (FRED; MicroVention Inc., Aliso Viejo, CA, USA) has almost never been reported. Herein, we report a case of acute distal migration of a single FRED secondary to in-stent thrombi with symptomatic ischemic stroke and review the literature on the distal migration of FDs.

Case Description:
A 35-year-old woman was diagnosed with a left unruptured internal carotid-ophthalmic artery aneurysm. A 3.5 mm diameter and 17 mm long FRED was adequately deployed. The patient awoke from general anesthesia without neurological deficits. However, shortly after the procedure, the patient presented with conjugate deviation toward the left side, right severe hemiparesis, and total aphasia. Although the symptoms gradually improved, angiography was performed. Angiography revealed some in-stent thrombi and distal migration of the FRED, and initially, one of the left M2 inferior trunk branches was occluded by an embolic thrombus. However, the thrombus spontaneously migrated distally without any specific treatment. Finally, despite leaving the migrated stent in situ, the flow almost completely improved, and the patient’s neurologic deficits disappeared. Magnetic resonance imaging following treatment revealed only a small cerebral infarction in the left temporo-occipital area.

Conclusion:
Distal migration of an FD in an acute setting, including the FRED, may occur even following appropriate placement. In-stent thrombosis can cause distal stent migration and thromboembolic stroke.
MODERN TRENDS IN THE DEVICE OF ENZYME AMPEROMETRIC BIOSENSORS
Authors: Туманов Григорий Алексеевич , Лакина Наталия Валерьевна , Долуда Валентин Юрьевич , Сульман Михаил Геннадьевич 
Published: March 2022

На сегодняшний день оптимизации биосенсоров путем различных методов нанесений или подбора эффективных систем окислительно-восстановительных ферментов посвящено множество исследований. В статье приведен обзор способов получения биосенсоров, включающих такие системы ферментов как лактатдегидрогеназа/пируватоксидаза, лактатоксидаза/пероксидаза/глюкозооксидаза, глюконаткиназа/креатинкиназа и саркозиноксидаза/пероксидаза, пероксидаза/глюкозооксидаза, глюкозооксидаза/β-галактозидаза. Проанализировано влияние принципов иммобилизации и количества ферментов на эффективность получаемых систем. Мультиферментные биосенсоры, содержащие два или более ферментов, демонстрировали многообещающие стабильность и селективность, что свидетельствует о перспективности исследований в данном направлении.
To date, many studies have been devoted to the optimization of biosensors by means of various methods of application or selection of effective systems of redox enzymes. The article provides an overview of methods for obtaining biosensors, including such enzyme systems as lactate dehydrogenase / pyruvate oxidase, lactate oxidase / peroxidase / glucose oxidase, gluconate kinase and sarcosine kinase / creatosine / peroxidase, peroxidase / glucose oxidase, glucose oxidase / β-galactosidase. The influence of the principles of immobilization and the amount of enzymes on the efficiency of the resulting biosensors was analyzed - multienzyme biosensors containing two or more enzymes demonstrated promising stability and selectivity, which indicates that research in this direction is promising.
INFLUENCE OF ABIOTIC ENVIRONMENTAL FACTORS ON THE STABILIZATION OF PETROLEUM EMULSIONS IN THE PRESENCE OF HUMIC ACIDS
Authors: Дмитриева Елена Дмитриевна , Герцен Мария Михайловна 
Published: March 2022

Изучена стабилизирующая способность гуминовых кислот торфов различного генезиса по отношению к нефти и нефтепродуктам в условиях абиотического стресса. Установлено, что универсальными стабилизирующими агентами по отношению к гексадекану, дизельному топливу и сырой нефти, действующими как в соленой воде при комнатной температуре, так и в пресной воде при пониженной температуре, являются гуминовые кислоты черноольхового низинного торфа: за все время проведения эксперимента величина пропускания эмульсий токсикантов уменьшилась на 11-32% относительно контроля. Выявлены сходства по результатам стабилизирующей способности эмульсии гексадекана и дизельного топлива при повышенной солености и пониженной температуре: максимальный стабилизирующей эффект проявляют гуминовые кислоты, относящиеся к одному типу исходного материала; разность коэффициентов пропускания относительно контроля составила 2%.
The stabilizing ability of peats humic acids of various genesis in the relation to oil and petroleum products under abiotic stress has been studied. It was found that the universal stabilizing agents to hexadecane, diesel fuel and crude oil, acting both in salt water at room temperature and in fresh water at a low temperature, are humic acids of black alder fen peat: for the entire time of the experiment, the emulsion transmission value toxicants decreased by 11-32% relative to control. The similarities were revealed according to the results of the stabilizing ability of the emulsion of hexadecane and diesel fuel at increased salinity and low temperatures: humic acids belonging to the same type of starting material exhibit the maximum stabilizing effect; the difference in transmittance relative to the control was 2%.
INFLUENCE OF BIOCOMPOSITION BASED ON HUMIC ACIDS AND OIL-DEGRADING MICROORGANISMS ON THE EMULSION OF OIL UNDER ABIOTIC STRESS
Authors: Дмитриева Елена Дмитриевна , Герцен Мария Михайловна 
Published: March 2022

Определена эмульгирующая способность биокомпозиций на основе гуминовых кислот и микроорганизмов-нефтедеструкторов рода Rhodococcus по отношению к нефти: качественный анализ нефтяных пленок показал, что максимальной нефтеутилизирующей способностью не зависимо от условий абиотического стресса (повышенной солености среды и пониженной температуры) обладают биокомпозиции на основе гуминовых кислот сфагнового верхового торфа + бактерии и гуминовых кислот тростникового низинного торфа + бактерии . Установлено, что высокая степень биодеградации нефти при добавлении суспензии биокомпозиций объясняется механизмом двойного действия бактерий-нефтедеструкторов и гуминовых кислот в условиях нефтезагрязнения: бактерии окисляют нефтепродукты, растворяя их или эмульгируя посредством выделения биосурфактантов. Гуминовые кислоты же являются эффективными стабилизирующими агентами по отношению к нефтепродуктам и, кроме того, являются субстратом для роста внесенных штаммов микроорганизмов.
The emulsifying ability of biocompositions based on peats humic acids and oil-degrading microorganisms of the genus Rhodococcus in the relation to oil was determined: a qualitative analysis of oil films showed that biocompositions based on humic acids of sphagnum highmoor peat + bacteria Rh. erythropolis X5 and humic acids of reed fen peat + bacteria Rh. erythropolis S67 have the maximum oil-utilizing capacity, regardless of the conditions of abiotic stress (increased salinity of the environment and low temperature). It has been established that the high degree of oil biodegradation upon the addition of a suspension of biocompositions is explained by the mechanism of the double action of oil-degrading bacteria and humic acids under conditions of oil pollution: bacteria oxidize oil products, dissolving them or emulsifying them through the release of biosurfactants. Humic acids are effective stabilizing agents in relation to petroleum products and, in addition, are a substrate for the growth of introduced strains of microorganisms.
BIOCATALYTIC PRETREATMENT OF LIGNIN-CONTAINING RAW MATERIALS
Authors: Шиманская Елена Игоревна , Гребенникова Ольга Валентиновна , Филатова Анастасия Евгеньевна 
Published: March 2022

Биокаталитическая деструкция лигнина с применением пероксидазы хрена является экономически выгодным процессом, проходящим при комнатной температуре, при этом позволяющим разбить сложную структуру лигнина на составляющие, которые легче подвергаются процессу гидрогенолиза. Соответственно, процесс гидрогенолиза после биокаталитической предобработки потребует меньших временных и энергетических затрат. В статье приведены экспериментальные данные по предобработке лигнина биокаталитическим методом с целью облегчения проведения дальнейшего процесса гидрогенолиза.
Catalytic destruction of lignin using horseradish peroxidase is an economically advantageous process that takes place at room temperature, while allowing the complex structure of lignin to be broken down into components that are more easily subjected to the process of hydrogenolysis. Accordingly, the process of hydrogenolysis after biocatalytic pretreatment will require less time and energy costs. The article presents experimental data on the pretreatment of lignin by the biocatalytic method in order to facilitate the further hydrogenolysis process.
FORMATION OF BASIC COPPER ACETATE NANOPHASE AND ITS STABILIZATION IN AQUEOUS MICELLAR SURFACE SOLUTIONS
Authors: Агеева Лилия Сергеевна , Борщ Николай Алексеевич , Кувардин Николай Владимирович , Кузьменко Александр Павлович 
Published: March 2022

При взаимодействии ацетата меди с гидрокарбонатом натрия в воде и водных мицеллярных растворах ПАВ наблюдается образование нанофазы основного ацетата меди. Методами светодинамического рассеяния, малоугловой рентгеновской дифракции и спектрофотометрии показано, что в этих случаях образуются наночастицы основного ацетата меди со сложной картиной распределения по размерам в интервале до 60 нм. Проведение реакции в водных мицеллярных растворах ПАВ приводит к седиментационной устойчивости нанофазы, зависящей от концентрации и природы ПАВ. Определена расчетная пороговая и экспериментальная начальная концентрация ацетата меди при взаимодействии с гидрокарбонатом натрия в воде и водных мицеллярных растворах ПАВ, при которых образуется нанофаза основного ацетата меди. Сформулированы условия получения наноразмерной устойчивой суспензии основного ацетата меди, которая может служить основой лечебной противоожоговой и ранозаживляющей композиции.
When copper acetate interacts with sodium bicarbonate in water and aqueous micellar solutions of surfactants, the formation of a nanophase of basic copper acetate is observed. It has been shown by the methods of dynamic light scattering, small-angle X-ray diffraction and spectrophotometry that in these cases nanoparticles of basic copper acetate are formed with a complex pattern of size distribution in the range of up to 60 nm. Carrying out the reaction in aqueous micellar surfactant solutions leads to sedimentation stability of the nanophase, which depends on the concentration and nature of the surfactant. The calculated threshold and experimental initial concentration of copper acetate in the interaction with sodium bicarbonate in water and aqueous micellar solutions of surfactants, at which the nanophase of basic copper acetate is formed. The conditions for obtaining a nanoscale stable suspension of basic copper acetate, which can serve as the basis for a therapeutic anti-burn and wound-healing composition, are formulated.
OXIDATIVE DEGRADATION OF TETRACYCLINE BY VARIOUS PEROXIDE SYSTEMS
Authors: Устинова Мария Николаевна , Филиппова Ксения Алексеевна 
Published: March 2022

Изучена окислительная деструкция тетрациклина рядом пероксидных систем различного состава: пероксид водорода в присутствии ионов железа (II), пероксид водорода в присутствии ионов железа (III), пероксид водорода в присутствии одновременно ионов железа (II) и (III), пероксид водорода в присутствии комплекса ЭДТА - Fe и пероксид водорода в присутствии комплекса ЭДТА - Fe. Определены оптимальные условия процесса, подобраны эффективные соотношения реагентов, рассчитаны степени деструкции и начальные скорости процессов. Показано, что совместное присутствие ионов железа (II) и ионов железа (III) в системе снижает расход пероксида водорода при окислении тетрациклина. Установлено, что замена гидратированных ионов железа на комплексы с ЭДТА незначительно влияет на эффективность окисления тетрациклина. Доказано, что в водных растворах действующее вещество тетрациклина может быть окислено при комнатной температуре и атмосферном давлении пероксидом водорода в присутствии ионов железа (II) и/или железа (III). Этот способ может быть рекомендован для деструкции и инактивации фармацевтических поллютантов тетрациклинового ряда.
The oxidative degradation of tetracycline was studied by the methods: hydrogen peroxide in the presence of iron (II) ions, hydrogen peroxide in the presence of iron (III) ions, hydrogen peroxide in the presence of iron (II) and (III) ions, hydrogen peroxide in the presence of the complex EDTA - Fe and hydrogen peroxide in the presence of the complex EDTA - Fe. The optimal conditions of the process are determined, the effective ratios of reagents are selected, the degrees of destruction and the initial speeds of the processes are calculated. It is shown that the combined presence of iron (II) ions and iron (III) ions in the system reduces the consumption of hydrogen peroxide during the oxidation of tetracycline. It was found that the replacement of hydrated iron ions with iron complexes with EDTA slightly affects the efficiency of tetracycline oxidation. It is proved that in aqueous solutions, the active substance of tetracycline can be oxidized at room temperature and atmospheric pressure with hydrogen peroxide in the presence of iron (II) and/or iron (III) ions. This method can be recommended for the destruction and inactivation of pharmaceutical pollutants of the tetracycline series.