bluuebunny/crossref_metadata_2025_split huggingface dataset:
Red blood cell depletion in small‐volume bone marrow processing using manipulation with third‐party red blood cells: A comparison of the performance of the COBE spectra and the spectra Optia systems
Authors: Sumii Yuichi , Fujii Nobuharu , Fujii Keiko , Kondo Takumi , Urata Tomohiro , Kimura Maiko , Washio Kana , Fujiwara Hideaki , Asada Noboru , Ennishi Daisuke , Nishimori Hisakazu , Matsuoka Ken‐ichi , Otsuka Fumio , Maeda Yoshinobu 
Published: August 2022

AbstractBackgroundFor pediatric recipients, red blood cells (RBCs) are added to bone marrow (BM) collections before low RBC volume BM processing using COBE Spectra (COBE) or Spectra Optia (Optia). However, the processing efficiency of this approach has not been evaluated. This study aimed to evaluate RBC depletion and nucleated cell subpopulation recovery rates in third‐party RBC‐manipulated BM products processed with the COBE or Optia.Study Design and MethodsWe retrospectively collected data on RBC depletion from low RBC volume BM with third‐party RBCs (manipulated group) and on conventional large‐volume, BM (unmanipulated group) processing performed between September 2010 and December 2021. All procedures were performed using COBE or Optia.ResultsThe median residual RBC volume in the manipulated group was 9.5 ml in COBE and 2.5 ml in Optia (p = .01). The median total nucleated cell (TNC) and mononuclear cell (MNC) were comparable between the manipulated groups using each cell separator (TNC, 40.8 vs. 47.1%; MNC, 78.3 vs. 79.4%). The manipulation did not adversely affect TNC and MNC recoveries in either device. In addition, Optia achieved similar CD34+ cell recovery to that in large‐BM‐volume processing using the same device (147.5 vs. 184.5%, p = .112). During a follow‐up period, neutrophil engraftment was achieved in all patients who received third‐party RBC‐manipulated grafts, and platelet engraftment was achieved in all cases, except one.ConclusionThe addition of third‐party RBC to low RBC volume BM collections from or for pediatric patients does not have any negative impact on either RBC depletion or hematopoietic cell recovery during processing with the widely used cell separator.
Hormones, age, and sex affect platelet responsiveness in vitro
Authors: Hadley Jamie B. , Kelher Marguerite R. , Coleman Julia R. , Kelly Kathleen K. , Dumont Larry J. , Esparza Orlando , Banerjee Anirban , Cohen Mitchell J. , Jones Kenneth , Silliman Christopher C. 
Published: August 2022

AbstractBackgroundFemale sex confers a survival advantage following severe injury in the setting of trauma‐induced coagulopathy, with female platelets having heightened responsiveness likely due to estrogen. The effects of testosterone on platelet biology are unknown, and platelets express both estradiol and androgen receptors on the plasma membrane. We hypothesize testosterone decreases platelet responses in vitro, and there are baseline differences in platelet function and metabolism stratified by sex/age.Study Design and MethodsApheresis platelets were collected from: older males (OM) ≥45 years, younger males (YM) <45 years, older females (OF) ≥54 years, and younger females (YF) <54 years, and testosterone and estradiol were measured. Platelets were incubated with testosterone (5.31 ng/ml), estradiol (105 pg/ml) or vehicle and stimulated with buffer, adenosine diphosphate (20 μM), platelet activating factor (2 μM), or thrombin (0.3 U/ml). Aggregation, CD62P surface expression, fibrinogen receptor surface expression, and platelet mitochondrial metabolism were measured.ResultsTestosterone significantly inhibited aggregation in OF and OM (p < .05), inhibited CD41a expression in YF, YM, and OM (p < .05), and affected a few of the baseline amounts of CD62P surface expression but not platelet activation to platelet‐activating factor and adenosine diphosphate, and variably changed platelet metabolism.DiscussionPlatelets have sex‐ and age‐specific aggregation, receptor expression, and metabolism. Testosterone decreases platelet function dependent on the stimulus, age, and sex. Similarly, platelet metabolism has varying responses to sex hormones with baseline metabolic differences dependent upon sex and age.
Noncompartmental pharmacokinetics of three intravenous mycophenolate mofetil concentrations in healthy Standardbred mares
Authors: Burroughs Dylan L. , Lorch Gwendolen , Guo Yizhen , Hill Kasey , Schroeder Eric L. , Cole Lynette K. , Phelps Mitch A. 
Published: August 2022

AbstractBackgroundMycophenolate mofetil (MMF) is the prodrug of mycophenolic acid (MPA) which acts as an immunosuppressive agent. During the biotransformation of MMF to MPA, additional metabolites including MPA phenol glucuronide (MPAG), MPA acyl glucuronide (AcMPAG) and MPA phenol glucoside (MPG) are formed.ObjectiveTo define the noncompartmental pharmacokinetic (PK) parameters of three single doses of intravenous (i.v.) MMF and its downstream metabolites in healthy horses.AnimalsSix healthy Standardbred mares.Materials and MethodsGeneric MMF (Par Pharmaceuticals; Chestnut Ridge, NY, USA) was reconstituted and administered as a single i.v. bolus at 1.0 mg/kg, 5.0 mg/kg and 10.0 mg/kg with an eight day washout between treatments. Blood samples were collected immediately before MMF administration and over 24 h. A liquid chromatography–tandem mass spectrometry assay was developed following FDA guidance to determine plasma MMF, MPA, MPAG, AcMPAG and MPG concentrations. Plasma concentrations were analysed independently, followed by calculation of geometric mean and coefficient of variation.ResultsNoncompartmental PK parameters were determined for MMF and all metabolites at all doses. MMF was rapidly converted to MPA in all horses. Each incremental dose of MMF resulted in increases in Cmaxand AUCinf_obs for MPA and the three additional metabolites. Within the 10‐fold dose range, the increase in Cmaxand AUCinf_obs for MMF and its metabolites was nonlinear.Conclusions and clinical relevanceHorses biotransform MMF into MPA, MPAG, AcMPAG and MPG via the glucuronidation and glucosidation clearance pathways. Equine reference PK profiles for MPA and the metabolites, MPAG, AcMPAG and MPG were established.
Non-Trivial Subring Perfect Codes in Unit Graph of Boolean Rings
Authors: Mudaber Mohammad Hassan , Sarmin Nor Haniza , Gambo Ibrahim 
Published: August 2022

The aim of this paper is to investigate the non-trivial subring perfect codes in a unit graph associated with the Boolean rings. We prove a subring perfect code of size , where , in the unit graphs associated with the finite Boolean rings . Moreover, we give a necessary and sufficient condition for a subring of an infinite Boolean ring to be a perfect code of size infinity in the unit graph.
The nature of waves in the arteries in memoriam: Nico Westerhof and John Tyberg
Authors: Parker Kim H. , de Tombe Pieter , van der Velden Jolanda , Westerhof Berend E 
Published: August 2022

AbstractThis memorial remembers the lives of two distinguished researchers who made major contributions to cardiovascular physiology; Nico Westerhof (1937–2022) and John Tyberg (1938–2022). It is a joint memorial not because they collaborated closely but because they held very different views about the nature of waves in the arteries. Their papers and particularly their lively discussions at many scientific meetings stimulated interest in the subject. Both were thoughtful and articulate about their views, and the debates were polite and dignified. They never resolved their differences and, after outlining what these differences were, we will suggest that perhaps there is no resolution. The authors of this memorial were close to one or the other protagonist; a son, a son‐in‐law and two close collaborators. We all have different views about the nature of waves in the arteries, but we all share great respect for both men and felt that a joint memorial was a fitting way to remember them and their many contributions. All of the authors knew the subjects of this memorial as ‘Nico’ and ‘John’, and we will use these informal names throughout.
Extraordinary Claims in the Literature on High-Intensity Interval Training: II. Are the Extraordinary Claims Supported by Extraordinary Evidence?
Authors: Ekkekakis Panteleimon , Tiller Nicholas B. 
Published: August 2022

Dishman challenged kinesiologists to seek a compromise between “the ideal physiological prescription and a manageable behavioral prescription.” High-intensity interval training (HIIT) is the first exercise modality that has been claimed to meet this challenge, combining substantial benefits for fitness and health with pleasure and enjoyment. If true, these claims may revolutionize the science and practice of exercise. In this paper, four claims are critically appraised: (a) HIIT lowers the risk of mortality more than moderate-intensity continuous exercise, (b) HIIT doubles endurance performance after only 15 min of training over 2 weeks, (c) 1 min of HIIT is equivalent to 45 min of moderate-intensity continuous exercise, and (d) HIIT is more pleasant and enjoyable than moderate-intensity continuous exercise. The evidence for these claims appears questionable. Kinesiology should heed the principle endorsed by Hume, Laplace, and Sagan, namely that extraordinary claims should be supported by commensurate evidence.
On the meaning of various mass definitions for asymptotically flat spacetimes
Authors: Vollick Dan N. 
Published: August 2022

In general relativity, the energy density of the gravitational field is not well defined. However, for asymptotically flat spacetimes, various definitions for total mass of the system have been proposed. In this paper, eight masses are considered and it is shown that some of them correspond to the active gravitational mass while the others correspond to the inertial mass. For example, the ADM mass corresponds to the inertial mass, while the Møller mass corresponds to the active gravitational mass. In general, the inertial and active gravitational masses are not equal. If the spacetime is vacuum at large r, the Einstein equations force the inertial and active gravitational masses to be the same. The Einstein equations also force these masses to be the same if any matter that extends out to large r satisfies the weak, strong, or dominant energy condition. The contributions of the inertial and active gravitational masses to the gravitational redshift, the deflection of light, the Shapiro time delay, the precession of perihelia, and the motion of test bodies in the spacetime are also examined.
Biochar–compost mixture and cover crop effects on soil carbon and nitrogen dynamics, yield, and fruit quality in an irrigated vineyard
Authors: Sharifi Mehdi , Hajiaghaei-Kamrani Monireh 
Published: August 2022

Effects of biochar–compost (B+Com) mixture and cover crop were assessed on soil and grapevine productivity in an irrigated Merlot ( Vitis vinifera L.) vineyard in Okanagan Valley, British Columbia (BC), Canada, from 2017 to 2020. The experimental design was a factorial arrangement of control, B+Com, cover crop, and combination of cover crop and B+Com (cover crop/B+Com) treatments in alleys with four replications. The B+Com comprised a 1:1 ratio of biochar and compost and was applied at a rate of 22 Mg ha−1 dry weight basis in May 2017 and 2019. The cover crop consisted of a dryland forage mixture and bird’s-foot trefoil ( Lotus corniculatus L.). B+Com treatment did not affect cover crop biomass or tissue C and N concentrations except for a 12% reduction in 2019 biomass. B+Com and cover crop/B+Com increased soil C content averaged across sampling dates by 11% and 17% ( P < 0.05), respectively, only at the 0–15 cm soil depth compared with the control. Cover crop treatment did not affect ( P < 0.05) soil C content at two soil depths in all sampling dates. Soil N content was not affected by B+Com, decreased by an average of 12.5% at both soil depths with cover crop, and increased with cover crop/B+Com by 4% only at the 0–15 cm soil depth averaged across sampling dates ( P < 0.05). Grape yield was increased by 32% by cover crop/B+Com relative to control only in 2020. The cover crop reduced petiole N and pruning weights in one or two years out of three.
One-loop Schwinger effect in the presence of Lorentz-violating background fields
Authors: Costa Rafael L. J. , Sobreiro Rodrigo F. 
Published: August 2022

AbstractIn this work we make use of proper-time method to evaluate Schwinger effect in the presence of Lorentz-violating background fields. Specifically, we evaluate the one-loop effective Lagrangian in the presence of Lorentz-violating time-like vector background $$b_\mu $$

b
μ

and pseudo-scalar $$m_5$$

m
5

for the pure electric case. The imaginary part of the effective Lagrangian is computed in order to calculate the Schwinger effect. Comments on phenomenology are also performed.
Exploring phase space with nested sampling
Authors: Yallup David , Janßen Timo , Schumann Steffen , Handley Will 
Published: August 2022

AbstractWe present the first application of a Nested Sampling algorithm to explore the high-dimensional phase space of particle collision events. We describe the adaptation of the algorithm, designed to perform Bayesian inference computations, to the integration of partonic scattering cross sections and the generation of individual events distributed according to the corresponding squared matrix element. As a first concrete example we consider gluon scattering processes into 3-, 4- and 5-gluon final states and compare the performance with established sampling techniques. Starting from a flat prior distribution Nested Sampling outperforms the Vegas algorithm and achieves results comparable to a dedicated multi-channel importance sampler. We outline possible approaches to combine Nested Sampling with non-flat prior distributions to further reduce the variance of integral estimates and to increase unweighting efficiencies.
Non-trivial class of anisotropic compact stellar model in Rastall gravity
Authors: Nashed G. G. L. , Hanafy W. El 
Published: August 2022

AbstractWe investigated Rastall gravity, for an anisotropic star with a static spherical symmetry, whereas the matter-geometry coupling as assumed in Rastall Theory (RT) is expected to play a crucial role differentiating RT from General Relativity (GR). Indeed, all the obtained results confirm that RT is not equivalent to GR, however, it produces same amount of anisotropy as GR for static spherically symmetric stellar models. We used the observational constraints on the mass and the radius of the pulsar Her X-1 to determine the model parameters confirming the physical viability of the model. We found that the matter-geometry coupling in RT allows slightly less size than GR for a given mass. We confirmed the model viability via other twenty pulsars’ observations. Utilizing the strong energy condition we determined an upper bound on compactness $$U_\text {max}\sim 0.603$$

U
max

∼
0.603

, in agreement with Buchdahl limit, whereas Rastall parameter $$\epsilon =-0.1$$

ϵ
=
-
0.1

. For a surface density compatible with a neutron core at nuclear saturation density the mass-radius curve allows masses up to $$3.53 M_\odot $$

3.53

M
⊙

. We note that there is no equation of state is assumed, however the model fits well with linear behaviour. We split the twenty pulsars into four groups according to the boundary densities. Three groups are compatible with neutron cores while one group fits perfectly with higher boundary density $$8\times 10^{14}$$

8
×

10
14

$$\hbox {g/cm}^3$$

g/cm
3

which suggests that those pulsars may have quark-gluon cores.
Analytically approximation solution to Einstein-Cubic gravity
Authors: Sajadi S. N. , Hendi S. H. 
Published: August 2022

AbstractIn this work, we introduce analytical approximate black hole solutions in Einstein-Cubic gravity. To obtain complete solutions, we construct the near horizon and asymptotic solutions as the first step. Then, the approximate analytic solutions are obtained through continued-fraction expansion. We also compute the thermodynamic quantities and use the first law and Smarr formula to obtain the analytic solutions for near horizon quantities. Finally, we follow the same approach to obtain the new static black hole solutions with different metric functions.
Inflation, SUSY breaking, and primordial black holes in modified supergravity coupled to chiral matter
Authors: Aldabergenov Yermek , Addazi Andrea , Ketov Sergei V. 
Published: August 2022

AbstractWe propose a novel model of the modified (Starobinsky-like) old-minimal-type supergravity coupled to a chiral matter superfield, that can simultaneously describe multi-field inflation, primordial black hole (PBH) formation, dark matter (DM), and spontaneous supersymmetry (SUSY) breaking after inflation in a Minkowski vacuum. The PBH masses in our supergravity model of double slow-roll inflation, with a short phase of “ultra-slow-roll” between two slow-roll phases, are close to $$10^{18}$$

10
18

g. We find that a significant PBH fraction in the allowed mass window can be supplemented by spontaneous SUSY breaking in the vacuum with the gravitino mass close to the scalaron (inflaton) mass M of the order $$10^{13}$$

10
13

GeV. Our supergravity model favors the composite nature of DM as a mixture of PBH and heavy gravitinos as the lightest SUSY particles. The composite DM significantly relaxes fine-tuning needed for the whole PBH-DM. The PBH-DM fraction is derived, and the second-order gravitational wave background induced by the enhanced scalar perturbations is calculated. Those gravitational waves may be accessible by the future space-based gravitational interferometers.
NHS Number Open Source Software: Implications for Digital Health Regulation and Development
Authors: Thimbleby Harold 
Published: August 2022

A national example of open source digital healthcare is critiqued. The code for implementing numeric patient identifiers is surprisingly naïve and bug-ridden, despite patient identifiers being computationally trivial and a critical component of reliable healthcare. The issues raised are shown to be widespread, long term, and apparently unrecognized. Problems are traced back to inadequacies in the relevant standards, and, at every stage, regulation through to development, inadequate Software Engineering input.An important finding is that the relevant healthcare standards are inconsistent and written without sufficient rigor to be at all constructive for implementing digital systems. The widely recognized problems of interoperability may be traced back to diverse (and buggy) interpretations of vague standards.
Effect of CICARE Communication Mode on Disease Uncertainty, Self-Nursing Ability, and Quality of Life in Patients with Coronary Atherosclerotic Heart Disease after Percutaneous Coronary Intervention
Authors: Hu Hui , Zhang Ayong , Wang Zhen 
Published: August 2022

Objective. To study the effect of CICARE (Connect, Introduce, Communicate, Ask, Respond, Exit) communication mode on disease uncertainty, self-nursing ability, and quality of life in patients with coronary atherosclerotic heart disease (CAD) after percutaneous coronary intervention (PCI). Methods. From January 2021 to December 2021, 102 patients with CAD after PCI were randomly divided into a research group (

n

=51) and a control group (

n

=51). The former received CICARE communication model nursing intervention, and the latter received routine doctor-patient communication nursing. To study the scores of disease uncertainty scale (MUIS), Frankl treatment compliance scale (Frankl), self-care ability scale (exercise of self-care-a), quality of life scale (WHOQOL-BREF), and Newcastle nursing satisfaction scale (NSNS) before and 1 week after nursing. Results. After one week of nursing, the MUIS score of the research group was lower than that of the control group, and the score of Frankl treatment compliance scale of the research group was higher than that of the control group. After 1 week of nursing, the ESCA score of the research group was higher compared to the control group (

p
<
0.05

), and the WHOQOL-BREF score of the research group was higher compared to the control group (

p
<
0.05

). After one week of nursing, the NSNS score of the research group was higher compared to the control group (

p
<
0.05

). Conclusion. The application value of CICARE communication mode nursing intervention in patients with CAD after PCI is more remarkable, and it is more helpful to reduce patients’ disease uncertainty, enhance treatment compliance, promote patients’ self-nursing ability, and strengthen quality of life and nursing satisfaction.
Characterization of Immune-Related Alternative Polyadenylation Events in Cancer Immunotherapy
Authors: Wang Gaoyang , Xie Zuozhong , Su Juan , Chen Meishan , Du Yanhua , Gao Qian , Zhang Guanxiong , Zhang Hailun , Chen Xiang , Liu Hong , Han Leng , Ye Youqiong 
Published: August 2022

Abstract

Alternative polyadenylation (APA) is an important posttranscriptional modification commonly involved in tumor development. However, the functional roles of APA in tumor immunity remain largely unknown. Here, we performed an in-depth analysis of the 3′UTR usage of protein-coding genes and tumor immune response in 10,303 tumor samples across 31 cancer types to develop the immune-related APA event (ImmAPA) score pipeline, an integrated algorithm to characterize the regulatory landscape of APA events in cancer immunity–related pathways. Tumor-specific ImmAPAs that strongly correlate with immune cell infiltration and immune checkpoint blockade (ICB) treatment–related biomarkers were identified. Among these ImmAPAs, the top-ranking COL1A1 3′UTR usage was strongly associated with worse prognosis and tumor immune evasion. Furthermore, a machine learning approach to construct an ICB-related ImmAPA score model predicted immunotherapy efficacy. Overall, the characterization of immune-related APA that corresponds to tumor progression and tumor immunity highlights the clinical utility of APA events as potential biomarkers in cancer immunotherapy.

Significance:
Elucidation of the landscape of immune-related alternative polyadenylation in cancer identifies alternative polyadenylation events that may play a role in immune modulation and immunotherapy efficacy.