bluuebunny/crossref_metadata_2025_split huggingface dataset:
The TNF-Alpha Inducing Protein is Associated With Gastric Inflammation and Hyperplasia in a Murine Model of Helicobacter pylori Infection
Authors: Morningstar-Wright Lindsay , Czinn Steven J. , Piazuelo M. Blanca , Banerjee Aditi , Godlewska Renata , Blanchard Thomas G. 
Published: February 2022

Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the human stomach leading to the development of chronic gastritis, peptic ulcers and gastric adenocarcinoma. A combination of host, environment and bacterial virulence factors contribute to disease development. The H. pylori TNFα inducing protein (Tipɑ) is a virulence factor shown to induce multiple pro-inflammatory cytokines in addition to TNFα in vitro. The goal of the present study was to elucidate the role of Tipα in promoting inflammation in vivo and to identify the molecular pathways associated with Tipα associated virulence. Mice were infected with wild-type Sydney strain (SS1) or a tipα mutant (Δtipα) for 1 month and 4 months. We also completed a second 4 months infection including a 1:1 SS1 to Δtipα co-infected group in addition to SS1 and Δtipα infected groups. The expression of TNFα, and KC were significantly higher in the SS1 infected group compared to both uninfected control (naïve) and Δtipα groups. Mice infected with Tipα expressing SS1 induced more severe histological gastritis and developed hyperplasia compared to Δtipα infected mice. Microarray analysis of gastric epithelial cells co-cultured with recombinant Tipα (rTipα) demonstrates up-regulation of the NFκB pathway. This data suggest Tipα plays an important role in H. pylori induced inflammation.
Domain-Based Functional Improvements in Bipolar Disorder After Interpersonal and Social Rhythm Therapy
Authors: Moot William , Crowe Marie , Inder Maree , Eggleston Kate , Frampton Christopher , Porter Richard J. 
Published: February 2022

BackgroundStudies typically report overall change in function when assessing bipolar disorder (BD) interventions, but individual domains are not analyzed. Which aspects of functioning are impacted is clearly important and may differ between treatments.MethodsData were analyzed from two previous clinical trials of Interpersonal and Social Rhythm Therapy (IPSRT) for BD patients. Change in total and subscale scores on the Social Adjustment Scale Self-Report (SAS-SR) from 0 to 78 weeks, were analyzed.Results152 BD patients took part in randomized controlled trials of IPSRT (n = 38) vs. Specialist Supportive Care (SSC) (n = 43), and of IPSRT (n = 41) vs. treatment as usual (TAU) which was discharge to primary care (n = 30). IPSRT was superior to TAU on change in the social and leisure activities and extended family subscales, and SAS-SR total score over 18 months.LimitationsStudies were not designed to be pooled. Patients in study 1 were younger and symptomatic at baseline. Patients assigned to TAU were more likely to drop-out. Patients did not respond to subscales that were not personally applicable (work, marital, children).ConclusionIPSRT had a positive impact on two SAS-SR subscales compared to TAU over 18 months. Other subscales were limited by the lack of respondents due to individual applicability. Different psychotherapy may have differential effects on different domains of function. Measures of function and research into functioning in BD should include domain-based measures, and report the numbers of participants who respond to questions in each domain.
An Evidence-Based Practice Developed in-situ: Let's Talk About Children and a Consolidation of Its Evidence Base
Authors: Allchin Becca , Solantaus Tytti 
Published: February 2022

BackgroundTraditional models of evidence-based practice assume knowledge is developed in research settings before being installed in practice settings. The role practice settings can play in enhancing effectiveness and enabling sustainability is not therefore acknowledged. Developing interventions in-situ alongside developing their evidence base, provides another pathway to evidence-based practice. One example is Let's Talk about Children (LTC), a brief family-focused intervention that promotes parent, family and child wellbeing. Let's Talk about Children has been developed and adapted to respond to the context into which it has been established, leading to different descriptions reported in its 20 year collection of evidence. Collating the diverse literature on LTC, this paper showcases an evidence-based practice developed in-situ in order to guide future innovation.MethodUsing an integrative review, key literature using LTC were identified through electronic databases and snowballing techniques. Constant comparison analysis synthesized the data to develop patterns and themes.FindingsFrom the 26 records, three forms of LTC were identified and outcomes related to parents, family and child wellbeing, implementation and sustainability were collated. Consolidated outcomes show overall agreement in effectiveness and acceptability outcomes across different settings and populations. Implementation and sustainability impacts are entwined with the context, and influenced by its development in-situ.ConclusionsThe study documents that the in-situ model is effective at developing sustainable evidence-based practice. In consolidating the evidence, the review clarified LTC's forms and outcomes, and draws attention to the importance of research on mechanisms of change.
Global Trends of Mean and Inequality in Multidimensional Wellbeing: Analysis of 1.2 Million Individuals From 162 Countries, 2009–2019
Authors: Shiba Koichiro , Cowden Richard G. , Gonzalez Natasha , Lee Matthew T. , Lomas Tim , Lai Alden Yuanhong , VanderWeele Tyler J. 
Published: February 2022

IntroductionHuman flourishing is a multidimensional concept characterized by a state of complete wellbeing. However, much of the prior research on wellbeing has principally focused on population averages assessed using a single item of wellbeing. This study examined trends in population averages and inequalities for a multidimensional index of wellbeing and compared emergent patterns with those found for Cantril's ladder, a measure of life satisfaction commonly used as a unidimensional index of wellbeing.MethodsData were from the Gallup World Poll from the years 2009 to 2019, a repeated cross-sectional survey of nationally representative samples comprising ~1.2 million individuals from 162 countries. We assessed five domains of flourishing: (1) happiness, (2) health, (3) purpose, (4) character, and (5) social relationships. We used the Gini Index to estimate inequalities in wellbeing within populations. We examined and compared country ranking, global and region-specific trajectories of mean and inequality, and relationships with age for flourishing and Cantril's ladder.ResultsAlthough all trends were highly correlated across the two metrics of wellbeing, we identified distinct patterns in flourishing concerning geography, time, and age relationships that were not observed for Cantril's ladder. Temporal trends and age relationships were different across domains of flourishing. Evidence of changing inequalities in wellbeing was also found, even when population averages were high or stable over time.ConclusionComprehensive measures of wellbeing are needed to capture the complex and changing patterns of wellbeing both within and across populations.
Association Between Gestational Diabetes Mellitus and Future Risk of Kidney Stones
Authors: Mao Yuanyuan , Hu Wenbin , Liu Li , Liu Qin 
Published: February 2022

ObjectiveThe association between history of gestational diabetes mellitus (GDM) and risk of kidney stones has not been reported. GDM increases the risk of long-term complications including diabetes, hypertension and metabolic syndrome, which are risk factors of kidney stones. This study aimed to explore the association between previous GDM and odds of kidney stones.MethodsWomen (age ≥ 20 years) who had delivered at least one live birth were included from the 2007–2018 National Health and Nutrition Examination Survey cohort (N = 12,003). Patients with kidney stones and history of GDM were identified by in-home interview for all participants. Subgroup analyses were conducted by age, race/ethnicity, postpartum duration and status of hypertension, obesity, current diabetes and metabolic syndrome.ResultsPrevious GDM was positively associated with odds of kidney stones [multivariate-adjusted odds ratio (95% confidence interval): 1.41 (1.13–1.77)], and the association was stronger with odds of passing 2 or more times of kidney stones [1.72 (1.31–2.26)]. In subgroup analyses, the association between previous GDM and odds of kidney stones was significant in women within 15 years of a pregnancy complicated by GDM [1.54 (1.12–2.11)], in obese participants [1.56 (1.18–2.06)], in women without hypertension [1.49 (1.07–2.08)], current diabetes [1.38 (1.02–1.87)] and metabolic syndrome [1.56 (1.10–2.19)], in women of Non-Hispanic White [1.59 (1.15–2.18)] and in women aged more than 50 year [1.45 (1.02–2.07)].ConclusionsPrevious GDM was positively associated with odds of kidney stones, and the association was independent of type 2 diabetes, hypertension and metabolic syndrome.
Preoperative Left Ventricular Energy Loss in the Operating Theater Reflects Subjective Symptoms in Chronic Aortic Regurgitation
Authors: Kainuma Atsushi , Itatani Keiichi , Akiyama Koichi , Naito Yoshifumi , Ishii Maki , Shimizu Masaru , Ohara Junya , Nakamura Naotoshi , Nakajima Yasufumi , Numata Satoshi , Yaku Hitoshi , Sawa Teiji 
Published: February 2022

BackgroundThere is currently no subjective, definitive evaluation method for therapeutic indication other than symptoms in aortic regurgitation. Energy loss, a novel parameter of cardiac workload, can be visualized and quantified using echocardiography vector flow mapping. The purpose of the present study was to evaluate whether energy loss in patients with chronic aortic regurgitation can quantify their subjective symptoms more clearly than other conventional metrics.MethodsWe studied 15 patients undergoing elective aortic valve surgery for aortic regurgitation. We divided the patients into symptomatic and asymptomatic groups using their admission records. We analyzed the mean energy loss in one cardiac cycle using transesophageal echocardiography during the preoperative period. The relationships between symptoms, energy loss, and other conventional metrics were statistically analyzed.ResultsThere were seven and eight patients in the symptomatic and asymptomatic groups, respectively. The mean energy loss of one cardiac cycle was higher in the symptomatic group (121 mW/m [96–184]) than in the asymptomatic group (87 mW/m [80–103]) (p = 0.040), whereas the diastolic diameter was higher in the asymptomatic group (65 mm [59–78]) than in the symptomatic group (57 mm [51–57]) (p = 0.040). There was no significant difference between the symptomatic and asymptomatic groups in terms of other conventional metrics.ConclusionsAn energy loss can quantify patients' subjective symptoms more clearly than other conventional metrics. The small sample size is the primary limitation of our study, further studies assessing larger cohort of patients are warranted to validate our findings.
Biocompatibility and Antibacterial Action of Salvadora persica Extract as Intracanal Medication (In Vitro and Ex Vivo Experiment)
Authors: Abdeltawab Samah Samir , Abu Haimed Tariq S. , Bahammam Hammam Ahmed , Arab Wafaa Talat , Abou Neel Ensanya A. , Bahammam Laila Ahmed 
Published: February 2022

This study aimed to test the biocompatibility and antibacterial properties of Salvadora persica (S. persica) extract, a natural product, as an intracanal medication in comparison with calcium hydroxide (Metapaste, META BIOMED, Cheongju, Korea). The pH values of both materials were tested. The biocompatibility of S. persica extract and Metapaste was determined using light microscopy and MTT assays. The antibacterial action was tested using the zone of bacterial inhibition on four common bacterial species. In addition, intracanal medication was administered using 68 extracted single-rooted teeth contaminated with Enterococcus faecalis (E. faecalis), and the percentage reduction in colony count (% RCC) at 1, 3, and 7 days was measured. The extension of activity for both materials was assessed using histological sections and scanning electron microscopy. S. persica was found to be acidic in nature. Both materials showed significantly lower cell viability than the positive control cells on days 1 and 3 but not on day 7. S. persica showed better antibacterial effects against E. faecalis and S. mutans. S. persica extract showed 97.6%, 98.9%, and 99.3% RCC values at 1, 3, and 7 days, respectively, which are comparable to those of Metapaste. S. persica herbal extract is a promising material that can be utilized as an intracanal medication, but its use requires further research.
A Study of Students’ Perception: Identifying EFL Learners’ Problems in Speaking Skill
Authors: Riadil Ikrar Genidal 
Published: February 2022

Language is a pivotal aspect of human being. By learning, language people can communicate with each other, get information from one to another and interact. Unfortunately, in the real condition, it is still difficult for Indonesian students to practice their English ability in daily conversation. This paper will discuss the student’s perception within implementation problems and its solutions. The aim of this study is to identify the speaking problems experienced by EFL learners in speaking English. The researcher conducted this study using the qualitative research method. To gather the results, the researcher uses a questionnaire centered on the Penny Tang (1997) on speaking problems in learning a foreign language. The study’s data is collected from thirty-five students from Tidar University in Magelang. The result of the study is that the students have problems in learning speaking English. The most problematic for the students is mother tongue use, 77% students use their other tongue in English class and 83% agree that mother tongue is easier than English.
Patogenisitas Metarhizium huainamdangense Isolat Dumoga Timur Terhadap Wereng Batang Coklat (Nilaparvata lugens) Pada Tanaman Padi Sawah
Authors: Wongkar Jusak , Tarore D , Rimbing J 
Published: February 2022

Brown planthoppers have been reported to be resistant to various types of insecticides. One of the environmentally friendly controls is the use of entomopathogenic fungi. This study aims to test the effectiveness of the entomopathogenic fungus M. huainamdangense local isolates against brown planthoppers. Pathogenicity testing of local isolates of M. huainamdangense used a completely randomized design (CRD) with five treatments, namely K1 (Density 106), K2 (Density 107), K3 (Density 108), K4 (Density 109) and K0 as control. Each treatment was repeated 5 (five) times. The results showed that the fastest treatment to kill insects up to 100% was in the K4 treatment (density 109). The results of the probit analysis showed the LT50 value in the conidium density treatment 109 (K4) at 1.6 days. Meanwhile, the LC50 value showed a concentration of 108.9 conidium/ml on the second day. The use of a lower concentration of conidia density was able to kill 50% of insects in a longer time. Keywords: Metarhizium huainamdangense; entomopathogen; Nilaparvata lugens ABSTRAKWereng coklat telah dilaporkan resisten terhadap berbagai jenis insektisida. Salah satu pengendalian yang ramah lingkungan, yaitu dengan penggunaan jamur entomopatogen. Penelitian ini bertujuan untuk menguji keefektifan jamur entomopatogen M. huainamdangense isolat lokal terhadap wereng coklat. Pengujian patogenisitas isolat lokal M. huainamdangense menggunakan Rancangan Acak Lengkap (RAL) dengan lima perlakuan yaitu perlakuan K1 (Kerapatan 106), K2 (Kerapatan 107), K3 (Kerapatan 108), K4 (Kerapatan 109) dan K0 sebagai kontrol. Setiap perlakuan diulang 5 (lima) kali. Hasil penelitian menunjukkan bahwa perlakuan yang paling cepat mematikan serangga hingga 100% yaitu pada perlakuan K4 (Kerapatan 109). Hasil analisis probit menunjukkan nilai LT50 pada perlakuan kerapatan konidium 109 (K4) yaitu pada 1,6 hari, sedangkan nilai LC50 menunjukkan konsentrasi 108,9 konidium/ml pada hari kedua. Penggunaan konsentrasi kerapatan konidia yang lebih rendah mampu mematikan 50% serangga dalam waktu yang lebih lama. Kata kunci: Metarhizium huainamdangense; entomopatogen; Nilaparvata lugens
STRUKTUR KOMUNITAS IKAN TARGET DI EKOSISTEM TERUMBU KARANG PADA ZONA TRADISIONAL PULAU BUNAKEN, TAMAN NASIONAL BNAKEN
Authors: Mandolang Meilisa , Kusen Janny D , Warouw Veibe , Paulus James H , Rember Unstain NWJ 
Published: February 2022

This study aims to determine the structure of the target fish community, including species composition, type of research and to analyze the ecological index in which the diversity index, uniformity index, dominance index, and community similarity index. Data collection was carried out in coral reef ecosystems in the traditional zones of Madolin, Alung Banua, Sachiko, Muka Kampung, and East Bunaken areas, all data collection areas were included in the Bunaken National Park area. Data was taken using the Underwater Visual Census method, also equipped with a documentation search for underwater photography and videography carried out at the Marine Biology laboratory, Faculty of Fisheries and Marine Sciences, UNSRAT. There are 3 families, 21 species and 130 individuals at the Madolin area, 5 families, 24 species, and 72 individuals at the Alung Banua area, 5 families, 23 species, and 77 individuals at the Sachiko area, 2 families, 11 species and 129 individuals at the Sachiko area. Muka Kampung, and 4 families, 18 species, and 160 individuals at the East Bunaken location. The calculated ecological index values obtained are H' 2.11 (Madolin), 2.90 (Alung Banua), 2.65 (Sachiko), 1.57 (Muka Kampung), 1.67 (East Bunaken) indicating the ecological condition of the ecosystem. coral reefs are still stable even though diversity is classified as moderate but inversely proportional to low dominance ranging from 0.07 to 0.33 on average. The results of the community similarity analysis using the Sorense index (<50%) showed that there was no similarity in reef fish communities between the 4 stations, namely (Madolin & Alung Banua), (Madolin & Muka Kampung), and (Muka Kampung & East Bunaken). Keywords : target fish community, diversity, dominance, community similarity
ESTIMASI KANDUNGAN KARBON BIOMASA PNEUMATOFOR Avicennia marina
Authors: Kindangen Gilbert , Sondak Calvyn , Kumampung Deisli R H 
Published: February 2022

Mangrove forests play an important role in mitigating the effects of global warming as mangroves can absorbs and stores carbon therefor, mangrove plants including A. marina can act as carbon sinks. The study aim is to estimate the carbon content contained in A. marina pneumatophore biomass. The data was taken b using line transect method. The number of research stations are 3 stations contain 3 plots (10 x 10 m2) for each station. Samples were taken at low tide by established 3 microplots (50 x 50 cm2) in each 10 x10 m2 plots. The results showed that the highest biomass value was found at Station 3 of 0.49 Kg/m2, followed by Station 1 of 0.42 Kg/m2, and the least pneumatophore biomass value was found at Station 2 of 0.41 Kg/m2. This finding is in line to the potenntial potential carbon content in pneumatophores where Station 3 has C content (0.08 Kg C/m2), dand 0.07 Kg C/m2 for both station 1 and 2 respectively. The average of C Contain in pneumatphores was 0.28 Kg C/m2. Keyword : Carbon Content, Biomass, Pneumatophores, Avicennia marina
STRUKTUR KOMUNITAS MANGROVE DI KELURAHAN TAPUANG, KECAMATAN TAHUNA, KABUPATEN SANGIHE
Authors: Pohos Romario , Sondak Calvyn F.A , Rumengan Antonius P 
Published: February 2022

The information about mangrove forest community structure in Tapuang village has never been reported. The location of the mangrove forest in this village is near to the settlements. Three line transects with 50 m distance were laid perpendicular to the shore. In each line transect, 5 quadrants (10 x 10 m2) were established. The data were analyzed using several parameters density, frequency, dominance, important index value and diversity. This study found 5 mangrove species namely Avicennia marina, Sonneratia alba, Sonneratia ovata, Rhizophora stylosa and Nypa fruticans. Avicennia marina was the most species found in each transects and had the highest density, frequency, and dominance values. The highest important value index (INP) was found in Avicennia marina in transect 2 with a INP value 183.80. Mangrove species diversity index for tree category in each transect was low (H'≤1) ranges from 0.99.Key Words: Tapuang Village, Mangrove, Community Structure
High-resolution STEM observation of the dynamics of Pt nanoparticles in a liquid
Authors: Takeguchi Masaki , Li Xiaoguang , Mitsuishi Kazutaka 
Published: February 2022

Abstract
The dynamics of Pt nanoparticles (NPs) in water are observed by high-resolution scanning transmission electron microscopy with a home-made static sandwich-type liquid cell (LC). Carbon is coated on both sides of the membrane windows of the LC to make them conductive. The slow motion of Pt NPs in thin water droplets enables us to acquire high-resolution scanning transmission electron microscopy images. Using a dose rate of 3 × 105 e nm−2s, some Pt NPs with a diameter of less than 2 nm disappear into the water, some move around, and others repeatedly attach to and detach from each other. The density of Pt NPs larger than 2 nm remains unchanged with further observation. However, by increasing the dose rate to 5.3 × 105 e nm−2s, the Pt NPs gather at the beam illumination area, and then form aggregates with chain network structures. It is also determined that the NPs attach to each other at their {111} surfaces.
Calibration and application of Gaussian random field models for exposure and resist stochastic in EUV lithography
Authors: Wei Chih-I , Latypov Azat , De Bisschop Peter , Khaira Gurdaman , Fenger Germain 
Published: February 2022

Abstract
Gaussian random field (GRF) models for EUV lithography (EUVL) exposure and resist process address the randomness of the EUVL process outcomes manifested as line edge roughness, line width roughness or catastrophic failures of pinching, bridging or missing vias. The paper presents the background of GRF models for EUVL processes and discusses the application of such models for fast calculation of success or failure probability of the lithographic process or various stochastic metrics quantifying the stochastic variability of the EUVL process outcome. The paper further concentrates on the approaches to calibration of GRF models. The presented results demonstrate the accuracy of GRF models by comparing the failure probabilities calculated using fast methods against the same probabilities estimated using Monte Carlo trials. The approaches to calibration of GRF EUVL models are demonstrated on experimentally measured data for one of the EUVL processes implemented at IMEC, Belgium.