bluuebunny/crossref_metadata_2025_split huggingface dataset:
FEATURES OF ZnO APPLICATION IN THE STRUCTURE OF HYDROGEN FUEL CELL
Authors: Ostroverkh Anna , Ostroverkh Yevhenii , Kovalenko Leonid , Samelyuk Anatoly , Bezdorozhev Oleksii , Vasylyev Oleksandr , Solonin Yurii 
Published: January 2022

The work is devoted to zinc oxide and the prospects of its use for the needs of hydrogen energy. The influence of zinc oxide on electrolyte materials for ceramic fuel cells is determined. The properties of ceramics based on 8YSZ were investigated by adding 0.5 wt.% nanopowder of zinc oxide according to the me­thod of the research of zinc oxide ceramics. The electrical conductivity of 8YSZ in an oxy­gen atmosphere shows a better conductivity characteristic, but 8YSZ-ZnO ceramics have better mechanical properties and higher reactivity in real fuel cell conditions.
It was found that zinc oxide has a positive effect on the open voltage of SOFC in the temperature range from 320 °C to 600 °C. The maximum value of the open voltage for the electrolyte 8YSZ-ZnO was obtained at a temperature of 520 °C with a value of 1.02 V, in turn for the electrolyte of pure 8YSZ the maximum value was 0.92 V at a temperature of 600 °C. The small amount of data on the use of pure zinc oxide as an electrolyte opens up opportunities for thorough analysis and determination of optimal technological parameters that will accelerate the introduction of hydrogen energy technologies with operating tempe­ratures below 600 ºC. From a brief overview of existing zinc oxide-based materials in fuel cells, materials with mixed conductivity and low sintering temperatures are the most promising and effective for implementation in real systems.
Data on the effect of sintering temperature on the porosity of ceramics with 8YSZ-ZnO and 8YSZ determined that the porosity of samples of both types decreases significantly with increasing sintering temperature of powders, but the addition of zinc oxide to 8YSZ-ZnO composite allows to obtain dense ceramics at temperatures below 100 °C than for pure 8YSZ. Regarding the strength of 8YSZ-ZnO ceramics, it increases with increasing sintering temperature and has higher values ​​relative to pure 8YSZ. Both porosity and strength change rapidly in the range of 1200–1300 °C and slowly in the range of 1300–1400 °C, due to the sintering temperature of ceramics made of pure zinc oxide 1100–1200 °C. Improving the sintering conditions of ceramics and mechanical properties reveal its advantage in the addition of zinc oxide.
Fluorescent Copper Nanomaterials for Sensing NO2− and Temperature
Authors: Wang Ning , Ga Lu , Ai Jun , Wang Yong 
Published: January 2022

In this work, highly fluorescent copper nanomaterials were synthesized by using ascorbic acid as a ligand. The excitation wavelength of copper nanomaterials is 367 nm, and the emission wavelength is 420 nm. The size range is 5–6 nm. Nitrite can selectively quench the fluorescence of copper nanomaterials. Therefore, copper nanomaterials can be used to selectively detect nitrite ions. The linear equation is F = −32.94 c (NO2−) + 8,455, and the correlation coefficient is 0.9435. At the same time, we found that the fluorescence intensity of copper nanomaterials has a good correlation with temperature (20–60°C), which shows that they have great potential in the application of nanothermometers.
The Sensitivity of Tsunami Impact to Earthquake Source Parameters and Manning Friction in High-Resolution Inundation Simulations
Authors: Gibbons Steven J. , Lorito Stefano , de la Asunción Marc , Volpe Manuela , Selva Jacopo , Macías Jorge , Sánchez-Linares Carlos , Brizuela Beatriz , Vöge Malte , Tonini Roberto , Lanucara Piero , Glimsdal Sylfest , Romano Fabrizio , Meyer Jan Christian , Løvholt Finn 
Published: January 2022

In seismically active regions with variable dominant focal mechanisms, there is considerable tsunami inundation height uncertainty. Basic earthquake source parameters such as dip, strike, and rake affect significantly the tsunamigenic potential and the tsunami directivity. Tsunami inundation is also sensitive to other properties such as bottom friction. Despite their importance, sensitivity to these basic parameters is surprisingly sparsely studied in literature. We perform suites of systematic parameter searches to investigate the sensitivity of inundation at the towns of Catania and Siracusa on Sicily to changes both in the earthquake source parameters and the Manning friction. The inundation is modelled using the Tsunami-HySEA shallow water code on a system of nested topo-bathymetric grids with a finest spatial resolution of 10 m. This GPU-based model, with significant HPC resources, allows us to perform large numbers of high-resolution tsunami simulations. We analyze the variability of different hydrodynamic parameters due to large earthquakes with uniform slip at different locations, focal depth, and different source parameters. We consider sources both near the coastline, in which significant near-shore co-seismic deformation occurs, and offshore, where near-shore co-seismic deformation is negligible. For distant offshore earthquake sources, we see systematic and intuitive changes in the inundation with changes in strike, dip, rake, and depth. For near-shore sources, the dependency is far more complicated and co-determined by both the source mechanisms and the coastal morphology. The sensitivity studies provide directions on how to resolve the source discretization to optimize the number of sources in Probabilistic Tsunami Hazard Analysis, and they demonstrate a need for a far finer discretization of local sources than for more distant sources. For a small number of earthquake sources, we study systematically the inundation as a function of the Manning coefficient. The sensitivity of the inundation to this parameter varies greatly for different earthquake sources and topo-bathymetry at the coastline of interest. The friction greatly affects the velocities and momentum flux and to a lesser but still significant extent the inundation distance from the coastline. An understanding of all these dependencies is needed to better quantify the hazard when source complexity increases.
Correlation Between Serum Uric Acid and Body Fat Distribution in Patients With Polycystic Ovary Syndrome
Authors: Zhang Yuqin , Cai Meili , Dilimulati Diliqingna , Lin Ziwei , Sun Hang , Cui Ran , Fei Hongxiang , Gao Xinxin , Zeng Qiongjing , Shao Xiaowen , Zhang Manna , Qu Shen 
Published: January 2022

ObjectiveThis study aims to investigate the correlation between serum uric acid levels and body fat distribution in patients with polycystic ovary syndrome (PCOS).MethodsBetween May 2017 and March 2021, a total of 199 patients with PCOS were recruited from the Department of Endocrinology and Metabolism at the Shanghai Tenth People’s Hospital. Anthropometric characteristics, metabolic parameters, and reproductive hormones were measured. Hyperuricemia was defined as serum uric acid (SUA) greater than 420 μmol/l. Dual-energy X-ray absorptiometry (DEXA) was used to measure body fat distribution.ResultsThe prevalence of hyperuricemia in patients with PCOS was 28.64%. PCOS patients with hyperuricemia are more obese and have a higher waist-to-hip ratio (WHR) and worse lipid metabolism than those without hyperuricemia. According to SUA quartiles, patients in the highest quartile had higher total testosterone (TT), body fat accumulation, and lower sex hormone-binding globulin (SHBG) than patients in the lowest quartile. SUA was correlated with percentage of total body fat, arm fat mass, leg fat mass, trunk fat mass, android/gynoid (A/G) ratio, and visceral adipose tissue (VAT) mass. After controlling possible confounders, logistic regression analysis found that only excessive VAT mass could significantly increase the risk of hyperuricemia in patients with PCOS.ConclusionIn patients with PCOS, a high level of VAT mass, but not other fat compartments, will exacerbate the risk of hyperuricemia. Attention should be paid to the role of excessive VAT in the occurrence and development of PCOS with hyperuricemia.
Further Delineation of the Spectrum of XMEN Disease in Six Chinese Pediatric Patients
Authors: Peng Xiaomin , Lu Yi , Wang Huijun , Wu Bingbing , Gan Mingyu , Xu Suzhen , Zhuang Deyi , Wang Jianshe , Sun Jinqiao , Wang Xiaochuan , Zhou Wenhao 
Published: January 2022

X-linked MAGT1 deficiency with increased susceptibility to EBV-infection and N-linked glycosylation defect (XMEN) disease is a primary immunodeficiency caused by loss-of-function variants in the MAGT1 gene. Only two patients from one family have been diagnosed with XMEN in China. In this study, we retrospectively analyzed the genetic, clinical, and immunological characteristics of six pediatric patients in a Chinese cohort. Medical records were retrieved, immunological phenotypes were assessed, and infectious microbes in patients were detected. Six male patients (mean age, 6.3 years) from five unrelated families were genetically diagnosed as XMEN. Five patients presented with a major complaint of elevated liver enzymes, while one patient was referred for recurrent fever, cough and skin rash. Five patients developed EBV viremia, and one patient developed non-Hodgkin’s lymphoma. Histopathological findings from liver biopsy tissues showed variable hepatic steatosis, fibrosis, inflammatory infiltration, and glycogenosis. Immune phenotypes included CD4 T-cell lymphopenia, elevated B cells, inverted CD4/CD8 ratios, and elevated αβDNTs. No pathogenic microbes other than EBV were identified in these patients. This study reports the clinical and molecular features of Chinese patients with XMEN. For patients with transaminase elevation, chronic EBV infection and EBV-associated lymphoproliferative disease, the possibility of XMEN should be considered in addition to isolated liver diseases.
Digitizing Scoring Systems With Extended Online Feedback: A Novel Approach to Interactive Teaching and Learning in Formative OSCE
Authors: Wang Chia-Chen , Wang Yu-Chin Lily , Hsu Yu-Han , Lee Haw-Chyuan , Kang Yu-Chan , Monrouxe Lynn Valerie , Chien Shao-Ju , Chen Te-Chuan 
Published: January 2022

ObjectivesObjective structured clinical examinations (OSCEs) are common for formative assessment. We developed an Online Smart Communicative Education System and aimed to explore the factors that affect the perceptions of both teachers and students for teaching and learning.Methods and AnalysisA two-year cross-sectional cohort study was undertaken. The program includes three parts. Part I Pre-OSCE: an online flipped class in preparation for task-related knowledge and skills. Part II OSCE-day: 10 tasks in one track formative OSCE. Part III Post-OSCE: extended online feedback for participants with further questions after the exam and raters with more feedback after reviewing their performance online. Principal component analysis with varimax rotation was performed to analyze the perceptions of students and teachers to the Online System by means of questionnaires.ResultsSeventy-six pharmacy students (male 32.9%) took the exam and 24 raters (male, 25%) participated in the scoring during the OSCEs. The mean G coefficient was 0.88. Seventy-six questionnaires from the students were obtained for the analysis. Results explained the cumulative variance of 73.9% for component (1) “Effects of extended online feedback”: 40% and (2) “Facilitation of learning”: 33.9%. Thirty-nine questionnaires from the raters who experienced the Online System were obtained for the analysis (male 23.1%). Results explained a cumulative variance of 77.3% for component (1) “Effects of extended online feedback”: 36.6%, (2) “Facilitation of scoring and feedback”: 24.5%, and (3) “Feasibility of online platform”: 16.2%, respectively.ConclusionWe demonstrated good reliability for digitizing the scoring system with educational support to facilitate teaching. “Effects of extended online feedback” was the major aspect in explaining the variance from the perceptions of students and raters by factor analysis. In comparison with traditional formative OSCEs, extended online feedback is a novel approach, which extends the process of learning and teaching among the learners and raters and overcomes the barriers of time limitation and distance.
Clinical Effectiveness of Platelet-Rich Plasma for Long-Bone Delayed Union and Nonunion: A Systematic Review and Meta-Analysis
Authors: Li Shang , Xing Fei , Luo Rong , Liu Ming 
Published: January 2022

BackgroundMore recently, there was a series of clinical studies focusing on local administration of platelet-rich plasma (PRP) in long-bone fracture patients suffering from delayed union and nonunion. Therefore, we performed a systematic review to evaluate the effectiveness of PRP injection for treatment of patients with long-bone delayed union and nonunion.MethodsRelevant clinical trials were selected by the main bibliographic databases, including Medline, PubMed, Embase, Web of Science, and the Cochrane library, to evaluate the effectiveness of PRP for long-bone fracture patients diagnosed with delayed union or nonunion by two reviewers independently. The main outcomes included healing rate, healing duration, pain relief, functional outcome, and complications.ResultsFinally, thirteen studies including four hundred and fifty-nine participants met the selection criteria and were included in this systematic review. These articles included three randomized controlled studies, one prospective study, and nine retrospective studies. 146 out of 155 (94.19%) patients treated with PRP during operation, and 144 out of 183 (78.69%) patients treated with PRP injection alone, exhibited bone consolidation. The healing rate of the PRP group (85.80%) was higher than that of the control group (60.76%). The mean bony union time of patients treated and untreated with PRP, were, respectively, 4.64 and 5.15 months. Four papers reported that PRP was effective in pain relief of patient with delayed union and nonunion. Complications, including small subcutaneous hematoma, subcutaneous swelling, and postoperative infection, were also reported in enrolled studies.ConclusionsPRP is a promising alternative treatment for patients with long-bone delayed union and nonunion. PRP could successfully promote the healing rate and relieve the pain of patients with delayed union and nonunion. However, the long-term adverse side and functional outcome in application of PRP still need further large-scale trials and long-term follow-up.Systematic Review Registrationhttps://www.researchregistry.com/browse-the-registry#home/registrationdetails/61dbd2f837e948001e68d5c5/, The identifying number is research registry 7525.
Multiomics Analysis of Structural Magnetic Resonance Imaging of the Brain and Cerebrospinal Fluid Metabolomics in Cognitively Normal and Impaired Adults
Authors: Eldridge Ronald C. , Uppal Karan , Shokouhi Mahsa , Smith M. Ryan , Hu Xin , Qin Zhaohui S. , Jones Dean P. , Hajjar Ihab 
Published: January 2022

IntroductionIntegrating brain imaging with large scale omics data may identify novel mechanisms of mild cognitive impairment (MCI) and early Alzheimer’s disease (AD). We integrated and analyzed brain magnetic resonance imaging (MRI) with cerebrospinal fluid (CSF) metabolomics to elucidate metabolic mechanisms and create a “metabolic map” of the brain in prodromal AD.MethodsIn 145 subjects (85 cognitively normal controls and 60 with MCI), we derived voxel-wise gray matter volume via whole-brain structural MRI and conducted high-resolution untargeted metabolomics on CSF. Using a data-driven approach consisting of partial least squares discriminant analysis, a multiomics network clustering algorithm, and metabolic pathway analysis, we described dysregulated metabolic pathways in CSF mapped to brain regions associated with MCI in our cohort.ResultsThe multiomics network algorithm clustered metabolites with contiguous imaging voxels into seven distinct communities corresponding to the following brain regions: hippocampus/parahippocampal gyrus (three distinct clusters), thalamus, posterior thalamus, parietal cortex, and occipital lobe. Metabolic pathway analysis indicated dysregulated metabolic activity in the urea cycle, and many amino acids (arginine, histidine, lysine, glycine, tryptophan, methionine, valine, glutamate, beta-alanine, and purine) was significantly associated with those regions (P &lt; 0.05).ConclusionBy integrating CSF metabolomics data with structural MRI data, we linked specific AD-susceptible brain regions to disrupted metabolic pathways involving nitrogen excretion and amino acid metabolism critical for cognitive function. Our findings and analytical approach may extend drug and biomarker research toward more multiomics approaches.
Nutritional Status According to the Short-Form Mini Nutritional Assessment (MNA-SF) and Clinical Characteristics as Predictors of Length of Stay, Mortality, and Readmissions Among Older Inpatients in China: A National Study
Authors: Liu Hongpeng , Jiao Jing , Zhu Minglei , Wen Xianxiu , Jin Jingfen , Wang Hui , Lv Dongmei , Zhao Shengxiu , Sun Xiang , Wu Xinjuan , Xu Tao 
Published: January 2022

BackgroundStudies are scarce in China that explore the association of nutritional status, measured using the Short-Form Mini Nutritional Assessment (MNA-SF) and biochemical data, on adverse clinical outcomes among older inpatients. In this study, we aimed to determine the prevalence of malnutrition in tertiary hospitals of China and the associations between malnutrition and adverse clinical outcomes.MethodsThis prospective study involved 5,516 older inpatients (mean age 72.47 ± 5.77 years) hospitalized in tertiary hospitals between October 2018 and February 2019. The tertiary hospitals refer to the hospital with more than 500 beds and can provide complex medical care services. The MNA-SF was used to assess nutritional status. Multiple logistic regression and negative binomial regression were used to analyze the relationship between nutritional parameters and risk of hospital length of stay (LoS), mortality, and rehospitalization.ResultsWe found that 46.19% of hospitalized patients had malnutrition or malnutrition risk, according to the MNA-SF. Death occurred in 3.45% of patients. MNA-SF scores 0–7 (odds ratio [OR] 5.738, 95% confidence interval [CI] 3.473 to 9.48) were associated with a six-fold higher likelihood of death, and scores 8–11 (OR 3.283, 95% CI 2.126–5.069) with a three-fold higher likelihood of death, compared with MNA-SF scores 12–14 in the logistic regression model, after adjusting for potential confounders. A low MNA-SF score of 0–7 (regression coefficient 0.2807, 95% CI 0.0294–0.5320;P&lt; 0.05) and a score of 8–11 (0.2574, 95% CI 0.0863–0.4285;P&lt; 0.01) was associated with a significantly higher (28.07 and 25.74%, respectively) likelihood of increased LoS, compared with MNA-SF score 12–14. MNA-SF scores 0–7 (OR 1.393, 95% CI 1.052–1.843) and 8–11 (OR 1.356, 95% CI 1.124–1.636) were associated with a nearly 1.5-fold higher likelihood of 90-day readmission compared with MNA-SF scores 12–14 in the logistic regression model. Moreover, hemoglobin level, female sex, education level, former smoking, BMI 24–27.9 kg/m2, age 75 years and above, and current alcohol consumption were the main factors influencing clinical outcomes in this population.ConclusionsMalnutrition increases the risk of hospital LoS, mortality, and 90-day readmission. The use of nutritional assessment tools in all hospitalized patients in China is needed. The MNA-SF combined with hemoglobin level may be used to identify older inpatients with a high risk of adverse clinical outcomes. These findings may have important implications for the planning of hospital services.
Ascites and Serial Plasma Circulating Tumor DNA for Predicting the Effectiveness of Hyperthermic Intraperitoneal Chemotherapy in Patients With Peritoneal Carcinomatosis
Authors: Pu Xiaolin , Li Zongyuan , Wang Xiaoying , Jiang Hua 
Published: January 2022

PurposeWe investigated the value of ascites and serial plasma circulating tumor DNA (ctDNA) for predicting response to hyperthermic intraperitoneal chemotherapy (HIPEC), monitoring tumor burden, and predicting prognosis in patients with peritoneal carcinomatosis (PC).Experimental DesignIn this observational study, 19 patients with PC were enrolled. Serial plasma ctDNA was analyzed using next-generation sequencing. The molecular tumor burden index (mTBI) was used to detect ctDNA, and concurrent changes in the dominant clone variant allele frequency (VAF) and common tumor markers were used as controls. The correlation between ascites and plasma ctDNA comutated genes was expressed by VAF. The overall response rate (complete response + partial response) after HIPEC was determined. Ascites progression-free survival (PFS) and overall survival (OS) were determined, and potential correlations between these outcomes and change in mTBI (△mTBI), change in sum-VAF (△sum-VAF), dominant close VAF, and tumor markers were assessed.ResultsThe overall response rate at 1 month after HIPEC was 100%. The △mTBI (r = 0.673; P = 0.023) and △sum-VAF (r = 0.945; P &lt;0.001) were significantly positively correlated with ascites PFS; these correlations were stronger than those of the dominant clone VAF (r = 0.588; P = 0.057) and tumor markers in the same period (r =0.091; P = 0.790). Patients with a low baseline mTBI (&lt;0.67) demonstrated significantly longer ascites PFS (P = 0.003; HR = 0.157; 95% CI: 0.046–0.540) and OS (P = 0.017; HR = 0.296; 95% CI: 0.109–0.804) than those with a high baseline mTBI (≥0.67). Consistent mutations were detected in plasma and ascites (r = 0.794; P = 0.001).ConclusionA real-time serial plasma ctDNA assay accurately reflected tumor burden. The △mTBI and △sum-VAF can be used as predictors of HIPEC efficacy in patients with PC. A high baseline mTBI may be a negative risk factor for prognosis.