bluuebunny/crossref_metadata_2025_split huggingface dataset:
Освіта як засіб досягнення цілей стійкого розвитку та інструмент формування організаційно-підприємницького капіталу в Україні: міждисциплінарний підхід
Authors: Майковська Вікторія 
Published: December 2022

Статтю присвячено проблемі формування організаційно-підприємницького капіталу української молоді в умовах орієнтації країни на досягнення цілей сталого розвитку. Розглянуто актуальність досягнення цілей сталого розвитку, розкрито роль освіти в цьому процесі. Відзначено, що економічне зростання є передумовою досягнення високого рівня життя, обґрунтовано сутність поняття «рівень життя», доведено зв’язок проблематики рівня життя й сфери освіти та професійної підготовки. Підкреслено виняткову роль людського капіталу у процесі поліпшення рівня життя населення. Встановлено залежність в умовах економіки знань власників засобів виробництва від носіїв прогресивних знань та професійних навичок, і, як наслідок, збільшення вартості й тривалості освітнього процесу. Наголошується, що розвиток людського капіталу в умовах економіки знань є важливим фактором досягнення цілей сталого розвитку.
Виявлено, що економіка знань визначає людський капітал як професійні знання, інтелектуальний потенціал, накопичення досвіду, які можуть бути застосованими у економічній діяльності. Зазначається, що виникла потреба в розробці програми формування, використання й відтворення людського капіталу, яка має міждисциплінарний характер і висуває перед освітою конкретні завдання щодо формування людського капіталу. Розглянуто форми і функції людського капіталу. Розкрито сутність організаційно-підприємницького капіталу як похідної форми людського капіталу. Доведено, що підприємці є рушійною силою економіки знань як носій знань і як сила, котра стимулює прагнення до інновацій, всебічно застосовуючи та використовуючи знання. Наголошується, що знання дозволяють власникам організаційно-підприємницького капіталу знаходити нові нетрадиційні можливості розвитку, освоювати нові ресурси, моделювати технології, розробляти засоби праці, ініціювати соціальні процеси, що забезпечує відтворення національного продукту й створення робочих місць.
Проведено аналіз вимог професійних стандартів педагогічних, науково-педагогічних працівників і керівників закладів освіти, виявлено відсутність наступності у даних вимогах залежно від рівня освіти щодо готовності педагогів до формування в здобувачів освіти організаційно-підприємницького капіталу. Зроблено висновок, що розв’язання проблеми формування організаційно-підприємницького капіталу в української молоді інституціональним шляхом наразі є спірним питанням і вимагає пошуку додаткових шляхів його рішення.
PİYASADA BULUNAN BAZI UÇUCU YAĞLARIN FARMAKOPE UYGUNLUĞUNUN DEĞERLENDİRİLMESİ
Authors: ERGENE Burçin , HADDUR Damla , KARAASLAN Melek , İLERİ ÖZLER Hediye Kamuran , SALTAN Hayriye 
Published: December 2022

Amaç: Uçucu yağlar; doğal kaynaklardan elde edilen ve vücutta fizyolojik etkilere sebep olan karışımlardır. Bu etkiler, uçucu yağın kimyasal bileşimine bağlı olarak değişkenlik gösterir. Bu nedenle, kullanılacak uçucu yağların dikkatli seçilmesi, beklenen etkinin görülebilmesi adına son derece önemlidir. Piyasada satılan uçucu yağların kaynağına ve kalitesine dair doğru bilgiye ulaşmak ise her zaman mümkün olmamaktadır. Fitoterapi ve aromaterapide terapötik ajan olarak, kimyasal içeriği bilinen ya da farmakope kalitesinde olan uçucu yağlar tercih edilmektedir. Bu uçucu yağlar; ağrı, uykusuzluk, egzema, stres nedenli anksiyete, depresyon ve hazımsızlık gibi ruhsal ve fiziksel rahatsızlıklarda etkin bir şekilde kullanılmaktadır.
Gereç ve Yöntem: Bu çalışma kapsamında; 10 adet lavanta uçucu yağı numunesi, 8 adet biberiye uçucu yağı numunesi, 10 adet limon uçucu yağı numunesi, 8 adet nane uçucu yağı numunesi, 9 adet bergamot uçucu yağı numunesi ve 6 adet fesleğen uçucu yağı numunesi olmak üzere, piyasada satışı olan 16 markanın, toplamda 51 adet uçucu yağının farmakope analizi yapıldı. Lavanta, biberiye, nane ve limon uçucu yağları için Türk Farmakopesi (2017), bergamot uçucu yağı için Fransız Farmakopesi (1991), fesleğen uçucu yağı için ise AFNOR Fransız Standartlarında yer alan monograflar doğrultusunda analiz şartları belirlendi. Fesleğen için elde edilen sonuçlar, Randriamiorisoa, 1995 (Manuel Rapide Et Utile Pour Producteurs D’Huiles Essentielles) içeriğindeki referans değerler ile de karşılaştırıldı.
Sonuç ve Tartışma: Piyasadan temin edilen numunelerle yapılan farmakope analizleri sonucunda elde edilen veriler ışığında; analizi yapılan uçucu yağlar arasında; lavanta uçucu yağı numunelerinden 3 tanesinin ve biberiye uçucu yağı numunelerinden 1 tanesinin farmakopeye tam olarak uygun sonuç verdiği, diğer uçucu yağ numunelerinin ise istenen spesifikasyonları tam olarak sağlamadığı görülmüştür. Numunesi temin edilen yağların farmakope analizi sonuçları, piyasadaki pek çok yağın farmakope kalitesinde olmadığını ortaya koymuştur.
PELATIHAN PELATIHAN PENINGKATAN PEMAHAMAN LINGKUNGAN UNTUK MENCEGAH KANKER PAYUDARA PADA MASYARAKAT
Authors: Riska Septia Wahyuningtyas  
Published: December 2022

Kanker Payudara menjadi masalah yang sering menyerang wanita mulai dari umur remaja sampai lanjut usia. Cara pencegahan kanker payudara yang efektif adalah mengetahui gejala awal kanker payudara dengan Gerakan SADARI. Jika pengetahuan kanker payudara ini diberikan sejak dini dan upaya pencegahannya juga dipahami sejak dini, maka remaja terutama siswa SMA akan terhindar dari resiko kanker tersebut. PKM ini dilakukan untuk menambah pengetahuan siswa tentang kanker payudara dan memberikan pemahaman siswa bahwa lingkungan dapat dipakai untuk meningkatkan kesehatan guna melawan jika ada bibit kanker payudara yang ada di tubuh kita. Pemberian pengetahuan kanker ini dengan mengajak salah satu Yayasan kanker SRIKANDI. PKM ini melakukan dua kegiatan utama yaitu kegiatan seminar secara online atau webinar dengan mengundang seluruh sekolah SMA yang ada di Jakarta dan kegiatan kedua yaitu memberikan alat Kesehatan kepada para penyintas kanker melalui Yayasan kanker SRIKANDI. Hasil dari PKM ini adalah meningkatkan pengetahuan masyarakat bahwa lingkungan merupakan hal utama yang dapat mempengaruhi kondisi psikologis seseorang. Lingkungan yang hijau dapat meningkatkan kondisi psikologis yang bahagia dan sehat. Kesehatan psikologis dapat mempengaruhi aktivitas imunitas tubuh. Semakin baik kondisi psikologis seseorang maka imunitasnya juga semakin baik. Semakin baik imunitas seseorang maka pertahanan seseorang terhadap bibit sel kanker payudara juga semakin baik. Maka perlu sekali peningkatan imunitas tubuh agar dapat terhindar dari penyakit kanker payudara.
Kata Kunci:kenker, payudara, lingkungan, pencegahan
Utilidad de la mamografía y la ecografía en tejido fibroglandular denso como tamizaje de cáncer de mama
Authors: Díaz Pérez Rodrigo Fabian , Arriciaga Vázquez Johana A. 
Published: December 2022

Introducción: La mamografía es el método de elección para el diagnóstico de cáncer de mama, sin embargo en senos con tejidos densos, su rendimiento disminuye. El objetivo del presente estudio fue establecer el valor de la mamografía y la ecografía para el tamizaje de cáncer de mama en mujeres con tejidos glandulares densos.
Metodología: Se realizó un estudio transversal, que incluyó por conveniencia 97 casos consecutivos de mujeres con tejido glandular denso en mamografía, al que se realizó estudio ecográfico complementario, atendidas entre 1-01-2017 al 31-12-2019 en el servicio de Imágenes del hospital Teodoro Maldonado Carbo. Se incluyeron aquellas que poseían estudio de lesión de mama por biopsia y/o de anatomía patológica. Para el análisis de método se calcularon sensibilidad, especificidad, valores predictivos positivos y negativos, cocientes de probabilidad positivos y negativos y porcentaje de exámenes correctamente realizado.
Resultados: La prevalencia de Cáncer de mama en la muestra fue 95%. Para el BIRADS mamográfico el rendimiento diagnóstico fue: DC 12.37%, S 7.61%, E 98.13%, VPP 98.68% VPN 5.56%, CPP nv, CPN 0.92. Para el BIRADS ecográfico fue de DC 43.30%, S 41.30%, E 80%, VPP 97.44, VPN 6.90%, CPP 2.07, CPN 0.73. Para el criterio del ecografista fue de DC 86.60%, S 91.30%, E 8.00%, VPP 94.38, VPN 5.56%, CPP 0.91, CPN nv.
Conclusión: La mamografía tuvo un bajo desempeño. En ecografía la utilización de BIRADS mejora el rendimiento. El criterio emitido por un ecografista experimentado logra el mayor desempeño para el diagnóstico de neoplasia maligna de mama en mujeres con tejido fibroglandular denso.
Smartphone-based particle image velocimetry for cardiovascular flows applications: A focus on coronary arteries
Authors: Caridi Giuseppe C. A. , Torta Elena , Mazzi Valentina , Chiastra Claudio , Audenino Alberto L. , Morbiducci Umberto , Gallo Diego 
Published: December 2022

An experimental set-up is presented for the in vitro characterization of the fluid dynamics in personalized phantoms of healthy and stenosed coronary arteries. The proposed set-up was fine-tuned with the aim of obtaining a compact, flexible, low-cost test-bench for biomedical applications. Technically, velocity vector fields were measured adopting a so-called smart-PIV approach, consisting of a smartphone camera and a low-power continuous laser (30 mW). Experiments were conducted in realistic healthy and stenosed 3D-printed phantoms of left anterior descending coronary artery reconstructed from angiographic images. Time resolved image acquisition was made possible by the combination of the image acquisition frame rate of last generation commercial smartphones and the flow regimes characterizing coronary hemodynamics (velocities in the order of 10 cm/s). Different flow regimes (Reynolds numbers ranging from 20 to 200) were analyzed. The smart-PIV approach was able to provide both qualitative flow visualizations and quantitative results. A comparison between smart-PIV and conventional PIV (i.e., the gold-standard experimental technique for bioflows characterization) measurements showed a good agreement in the measured velocity vector fields for both the healthy and the stenosed coronary phantoms. Displacement errors and uncertainties, estimated by applying the particle disparity method, confirmed the soundness of the proposed smart-PIV approach, as their values fell within the same range for both smart and conventional PIV measured data (≈5% for the normalized estimated displacement error and below 1.2 pixels for displacement uncertainty). In conclusion, smart-PIV represents an easy-to-implement, low-cost methodology for obtaining an adequately robust experimental characterization of cardiovascular flows. The proposed approach, to be intended as a proof of concept, candidates to become an easy-to-handle test bench suitable for use also outside of research labs, e.g., for educational or industrial purposes, or as first-line investigation to direct and guide subsequent conventional PIV measurements.
Fabrication and evaluation of herbal beads to slow cell ageing
Authors: Dhasmana Archna , Malik Sumira , Sharma Amit Kumar , Ranjan Anuj , Chauhan Abhishek , Harakeh Steve , Al-Raddadi Rajaa M. , Almashjary Majed N. , Bawazir Waleed Mohammed S. , Haque Shafiul 
Published: December 2022

Several therapies and cosmetics are available commercially to prevent or delay cell ageing, which manifests as premature cell death and skin dullness. Use of herbal products such as Aloe vera, curcumin, vitamin C-enriched natural antioxidant, and anti-inflammatory biomolecules are potential ways to prevent or delay ageing. Eggshell membrane (ESM) is also a rich source of collagen; glycosaminoglycans (GAGs) also play an essential role in healing and preventing ageing. It is important to use an extended therapeutic process to prolong the effectiveness of these products, despite the fact that they all have significant anti-ageing properties and the ability to regenerate healthy cells. Encapsulated herbal components are therefore designed to overcome the challenge of ensuring continued treatment over time to prolong the effects of a bioactive component after in situ administration. To study their synergistic effects on a cellular level, alginate, Aloe vera, and orange peel extract were encapsulated in bio-polymeric foaming beads and modified with eggshell membrane protein (ESMP) at various concentrations (1 gm, 2 gm, and 5 gm): (A-Av-OP, A-Av-OP-ESMP1, ESMP2, and ESMP3). Analysis of the structural and functional properties of foaming beads showed interconnected 3D porous structure, a surface-functionalized group for entrapment of ESMP, and a significant reduction in pore size (51–35 m) and porosity (80%–60%). By performing DPPH assays, HRBC stabilization assays, and antibacterial tests, the beads were assessed as a natural anti-ageing product with sustained release of molecules effective against inflammatory response, oxidative stress, and microbial contamination. MTT assays were conducted using in vitro cell cultures to demonstrate cytocompatibility (in mouse 3T3 fibroblast cells) and cytotoxicity (in human carcinoma HeLa cells). Our study demonstrates that bio-polymeric ESMP beads up to 2 g (A-Av-OP-ESMP2) are practical and feasible natural remedies for suspending defective cell pathways, preventing cell ageing, and promoting healthy cell growth, resulting in a viable and practical natural remedy or therapeutic system.
Microbubble contrast agent SonoVue: An efficient medium for the preoperative lymphatic mapping of thyroid carcinoma
Authors: Chen Lei , Dong Bingwan , Jiang Liu , Zhang Jixin , Chen Luzeng , Li Tiancheng , Shao Yuhong , Sun Xiuming 
Published: December 2022

Objective: To assess the value of microbubble contrast agent SonoVue in the thorough preoperative lymphatic mapping of patients with thyroid carcinoma, including the lymphatic drainage region, the detection of sentinel lymph node (SLN), and the diagnosis of lymph node metastasis (LNM).Materials and methods: 55 patients with 62 thyroid malignancies proved by surgical pathology (59 papillary thyroid carcinomas and three medullary thyroid carcinomas) who underwent preoperative lymphatic contrast-enhanced ultrasound (LCEUS) with microbubble contrast agent SonoVue were enrolled. All LNM were confirmed by pathology. The location of thyroid lesions, ultrasonic features of lymph nodes, lymphatic drainage region, and detection of SLN were assessed. The diagnostic performance (sensitivity, specificity, positive predictive value, negative predictive value and accuracy) of different parameters for the LNM diagnosis was calculated.Results: SonoVue effectively demonstrated the lymphatic drainage region for all enrolled thyroid carcinomas. The most common lymphatic drainage region for thyroid carcinomas was region VI (93.55%), followed by region III (62.90%), region IV (48.39%) and region II (4.84%). When divided by the lesion location, the most common lymphatic drainage regions for the nodule in isthmus, superior lobe and inferior lobe of the thyroid were region VI, region III, and region VI respectively. SLN was detected in 96.77% (60/62) of cases. The two cases without SLN demonstration had pathologically proven LNM. The most common sonographic sign of LNM was perfusion defect (54.17%). The diagnostic accuracy of SonoVue in central and lateral compartment LNM was 86.67% and 91.67%, respectively.Conclusion: Microbubble contrast agent SonoVue is a valuable imaging contrast medium for thorough preoperative lymphatic mapping in patients with thyroid carcinoma, including the lymphatic drainage region, the detection of SLN, and the diagnosis of LNM. LCEUS with SonoVue alone has limitations of false negatives when there is lymphatic vessel obstruction and may need to be combined with other ultrasound modalities.
Modified matrix solid phase dispersion-HPLC method for determination of pesticide residue in vegetables and their impact on human health: A risk assessment
Authors: Mujahid Majida , Latif Shoomaila , Ahmed Mahmood , Shehzadi Warda , Imran Muhammad , Ahmad Muhammad , Asari Asnuzilawati , Jehangir Muhammad , Mahmud Zaid 
Published: December 2022

The use of pesticides is unavoidable in agricultural practices. This class of chemicals is highly toxic for the environment as well as for humans. The present work was carried out to assess the presence of some pesticides (diafenthiuron, lufenuron, azoxystrobin, difenoconazole, and chlorothalonil) residues in five of the very commonly used vegetables (eggplant, capsicum, apple gourd, cauliflower, and sponge gourd). Matrix solid phase dispersion (MSPD) technique was used to extract the pesticides and subsequently their quantification was performed through high performance liquid chromatography (HPLC) coupled to ultraviolet-visible (UV-Vis) detector. The elution was accomplished at wavelength of 254 nm by injecting 20 µL of standards or samples into chromatographic system. The mobile phase consisted of acetonitrile and water (80:20 v/v), where the flow rate was adjusted at 1.0 ml/min. The linearity was good (R2 ≥ 0.994) over a concentration range from 20 to 100 μg/ml for the investigated pesticides. The low detection limits showed a quite appreciable potential of the method to detect (1.12–1.61 μg/L) and quantify (3.73–5.36 μg/ml) the pesticides under study. The accuracy was demonstrated in terms of percent recovery which ranged between 88.5% and 116.9% for all the pesticides under investigation. These results justify the suitability of the technique for the intended purpose. The concentration of difenoconazole in apple gourd (20.97 mg/kg), cauliflower (10.28 mg/kg), and sponge gourd (40.32 mg/kg) whereas diafenthiuron in cauliflower (0.66 mg/kg) exceeded the maximum residue level (MRLs) as defined by Food and Agriculture Organization of the United Nations and the World Health Organization (FAO/WHO). Target hazard quotient (THQ) values of difenoconazole and diafenthiuron (except for adults) were more than one which indicates the significant effect on human health on consumption of apple gourd, cauliflower, and sponge gourd.
Effect of angiotensin receptor-neprilysin inhibitor on atrial electrical instability in atrial fibrillation
Authors: Zhu Tianyu , Zhang Wenchao , Yang Quan , Wang Ning , Fu Yuwei , Li Yan , Cheng Guanliang , Wang Liang , Zhang Xian , Yao Hongying , Sun Xinghe , Chen Yu , Wu Xiaohui , Chen Xuezhi , Liu Xiaohui 
Published: December 2022

Background and objectiveAround 33.5 million patients suffered from atrial fibrillation (AF), causing complications and increasing mortality and disability rate. Upstream treatment for AF is getting more popular in clinical practice in recent years. The angiotensin receptor-neprilysin inhibitor (ARNI) is one of the potential treatment options. Our study aimed to investigate the effect of ARNI on atrial electrical instability and structural remodeling in AF.MethodsOur research consisted of two parts – a retrospective real-world clinical study and an animal experiment on calmness to verify the retrospective founding. In the retrospective study, we reviewed all patients (n = 110) who had undergone the first AF ablation from 1 August 2018 to 1 March 2022. Patients with ARNI (n = 36) or angiotensin II receptor antagonist (ARB) (n = 35) treatment were enrolled. Their clinical data, ultrasound cardiogram (UCG) and Holter parameters were collected before radiofrequency catheter ablation (RFCA) as baseline and at 24-week follow-up. Univariate and multivariate logistic regression analysis were performed. In the animal experiment, we established an AF model (n = 18) on canines by rapid atrial pacing. After the successful procedure of pacing, all the 15 alive beagles were equally and randomly assigned to three groups (n = 5 each): Control group, ARB group, and ARNI group. UCG was performed before the pacing as baseline. Physiological biopsy, UCG, and electrophysiological study (EPS) were performed at 8-week.ResultsClinical data showed that the atrial arrhythmia rate at 24-week was significantly lower in ARNI group compared to ARB group (P &lt; 0.01), and ARNI was independently associated with a lower atrial arrhythmia rate (P &lt; 0.05) at 24-week in multivariate regression logistic analysis. In the animal experiment, ARNI group had a higher atrial electrical stability score and a shorter AF duration in the EPS compared to Control and ARB group (P &lt; 0.05). In the left atrium voltage mapping, ARNI group showed less low voltage and disordered zone compared to Control and ARB group. Compared to Control group, right atrium diameter (RAD), left ventricle end-diastolic volume index (LVEDVI), E/A, and E/E′ were lower in ARNI group (P &lt; 0.05) at the 8-weeks follow-up, while left atrium ejection fraction (LAEF) and left ventricle ejection fraction (LVEF) were higher (P &lt; 0.01). Compared to ARB group, LVEF was higher in ARNI group at the 8-week follow-up (P &lt; 0.05). ARB and ARNI group had a lower ratio of fibrotic lesions in the left atrium tissues compared to Control group (P &lt; 0.01), but no difference was found between the ARB and the ARNI group.ConclusionARNI could reduce atrial electrical instability in AF in comparison with ARB in both retrospective study and animal experiment.
Worldwide impact of lifestyle predictors of dementia prevalence: An eXplainable Artificial Intelligence analysis
Authors: Bellantuono Loredana , Monaco Alfonso , Amoroso Nicola , Lacalamita Antonio , Pantaleo Ester , Tangaro Sabina , Bellotti Roberto 
Published: December 2022

IntroductionDementia is an umbrella term indicating a group of diseases that affect the cognitive sphere. Dementia is not a mere individual health issue, since its interference with the ability to carry out daily activities entails a series of collateral problems, comprising exclusion of patients from civil rights and welfare, unpaid caregiving work, mostly performed by women, and an additional burden on the public healthcare systems. Thus, gender and wealth inequalities (both among individuals and among countries) tend to amplify the social impact of such a disease. Since at present there is no cure for dementia but only drug treatments to slow down its progress and mitigate the symptoms, it is essential to work on prevention and early diagnosis, identifying the risk factors that increase the probability of its onset. The complex and multifactorial etiology of dementia, resulting from an interplay between genetics and environmental factors, can benefit from a multidisciplinary approach that follows the “One Health” guidelines of the World Health Organization.MethodsIn this work, we apply methods of Artificial Intelligence and complex systems physics to investigate the possibility to predict dementia prevalence throughout world countries from a set of variables concerning individual health, food consumption, substance use and abuse, healthcare system efficiency. The analysis uses publicly available indicator values at a country level, referred to a time window of 26 years.ResultsEmploying methods based on eXplainable Artificial Intelligence (XAI) and complex networks, we identify a group of lifestyle factors, mostly concerning nutrition, that contribute the most to dementia incidence prediction.DiscussionThe proposed approach provides a methodological basis to develop quantitative tools for action patterns against such a disease, which involves issues deeply related with sustainable, such as good health and resposible food consumption.