bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy of low‐frequency ultrasound as an added treatment for chronic wounds: A meta‐analysis
Authors: Chen Haiting , Yu Zhenxing , Liu Ning , Huang Jianbin , Liang Xia , Liang Xiaoling , Liang Meixia , Li Minghui , Ni Jiang 
Published: July 2022

AbstractWe performed a meta‐analysis to evaluate the effect of low‐frequency ultrasound as an added treatment for chronic wounds. A systematic literature search up to May 2022 was performed and 838 subjects with chronic wounds at the baseline of the studies; 412 of them were using the low‐frequency ultrasound (225 low‐frequency high‐intensity contact ultrasound for diabetic foot wound ulcers, and 187 low‐frequency low‐intensity non‐contact ultrasound for a venous leg wound ulcers), and 426 were using standard care (233 sharp debridements for diabetic foot wound ulcers and 193 sham treatments for venous leg wound ulcers). Odds ratio (OR), and mean difference (MD) with 95% confidence intervals (CIs) were calculated to assess the effect of low‐frequency ultrasound as an added treatment for chronic wounds using the dichotomous, and contentious methods with a random or fixed‐effect model. The low‐frequency high‐intensity contact ultrasound for diabetic foot wound ulcers had significantly lower non‐healed diabetic foot wound ulcers at ≥3 months (OR, 0.37; 95% CI, 0.24‐0.56, P < .001), a higher percentage of diabetic foot wound ulcers area reduction (MD, 17.18; 95% CI, 6.62‐27.85, P = .002) compared with sharp debridement for diabetic foot wound ulcers. The low‐frequency low‐intensity non‐contact ultrasound for a venous leg wound ulcers had a significantly lower non‐healed venous leg wound ulcers at ≥3 months (OR, 0.31; 95% CI, 0.15‐0.62, P = .001), and higher percentage venous leg wound ulcers area reduction (MD, 18.96; 95% CI, 2.36‐35.57, P = .03) compared with sham treatments for a venous leg wound ulcers. The low‐frequency ultrasound as an added treatment for diabetic foot wound ulcers and venous leg wound ulcers had significantly lower non‐healed chronic wound ulcers at ≥3 months, a higher percentage of chronic wound ulcers area reduction compared with standard care. The analysis of outcomes should be with caution because of the low sample size of all the 17 studies in the meta‐analysis and a low number of studies in certain comparisons.
Adverse events of metronidazole and amoxicillin: Retrospective analysis of a large data set of five randomized clinical trials
Authors: Retamal‐Valdes Belen , Tavares Ana Paula Laranjeira , Monique Sarah , Pereira da Silva Hélio Doyle , Mestnik Maria Josefa , Duarte Poliana Mendes , Miranda Tamires S. , Borges Ivan , Soares Geisla Mary Silva , Faveri Marcelo , Castro dos Santos Nidia , Graças Yasmin Teixeira das , Souto Maria Luisa Silveira , Giudicissi Marcela , Romito Giuseppe Alexandre , Saraiva Luciana , Pannuti Claudio Mendes , Figueiredo Luciene C. , Feres Magda 
Published: July 2022

AbstractAimTo evaluate the frequency of side effects associated with intake of metronidazole (MTZ) + amoxicillin (AMX) in periodontal treatment, and to explore associations between these events and patients' features.Materials and MethodsData of five randomized clinical trials testing MTZ + AMX adjunctive to mechanical therapy were evaluated. Volunteers answered an adverse event questionnaire.ResultsInformation from 656 subjects was assessed. The frequency of side effects in the antibiotic‐ and placebo‐treated groups ranged from 1.0% to 17.7% and 0.9% to 13.7%, respectively. The events more frequently observed in the antibiotic than in the placebo group were diarrhoea and metallic taste (p < .05). Diabetes significantly raised the odds of a patient reporting discomfort (odds ratio [OR] = 2.6), diarrhoea (OR = 4.0), weakness (OR = 6.0) and excessive sleepiness (OR = 2.9). In systemically healthy volunteers, using antibiotics 3 months post‐mechanical treatment (healing phase) (OR = 3.0), being a woman (OR = 3.9) and aged ≤49 (OR = 4.5) significantly increased the chances of reporting adverse events.ConclusionsThe occurrence of side effects during MTZ + AMX treatment ranged from uncommon (1%) to very common (17.7%). The main factors raising the chances of a patient reporting adverse events were diabetes and taking antibiotics in the healing phase, instead of in the active phase of treatment. Patients ≤ 49 years old and females also tend to report more side effects.
Factors affecting triage competence among emergency room nurses: A cross‐sectional study
Authors: Hwang Seokhwa , Shin Sujin 
Published: July 2022

AbstractAims and ObjectivesThe purpose of this study was to examine work‐related stress, nurse–physician collaboration and clinical reasoning competence to identify the factors that affected the triage competence of emergency room nurses.BackgroundA quick and accurate treatment plan for patients is first determined by a triage nurse. Triage competence is an indispensable requirement for emergency room nurses.DesignA cross‐sectional design was adopted.MethodsThe participants comprised 156 emergency room nurses in South Korea who had more than 1 year of experience working in an emergency room. The collected data were analysed using SPSS 28.0. Self‐reported data were collected via the Korean Nursing Stress, Nurse–Physician Collaboration, Nurse Clinical Reasoning, Emergency Room Nurse Triage Competence assessing work‐related stress, nurse–physician collaboration, clinical reasoning competence and triage competence. In the analyses, multiple regression analysis using the enter method was conducted. We have followed through the STROBE checklist for the preparation of this manuscript.ResultsTriage competence significantly differed according to the age (F = 9.93, p < .001), clinical experience (F = 18.82, p < .001), emergency department experience (F = 12.07, p < .001), triage experience (t = 4.40, p < .001) and if nurses had a triage certificate (t = 4.85, p < .001). The factors that influenced triage competence included clinical reasoning competence (β = .36, p < .001), emergency department experience (β = .21, p = .006), work‐related stress (β = .18, p = .007) and nurse–physician collaboration (β = −.17, p = .009); these factors accounted for 38.1% of the variance in triage competence.ConclusionThe results of this study show that efforts to improve triage competence should be based on clinical reasoning. In addition, an effective plan should be devised to improve nurse–physician collaboration and work‐related stress.Relevance to Clinical PracticeEducation programmes should be developed to enhance clinical reasoning competence in order to improve triage competence. In addition, a method for managing work‐related stress among nurses in emergency departments and programmes to enhance collaborative physician–nurse relations should be developed.
Bead‐anchored surgical templates for static computer‐assisted implant surgery: A dental technique
Authors: Orgev Ahmet , Pellerito John , Polido Waldemar , Morton Dean , Lin Wei‐Shao 
Published: July 2022

AbstractThis technique report describes an alternative method to stabilize surgical templates throughout full‐arch static computer‐assisted implant surgery (FA s‐CAIS). In FA s‐CAIS, remaining teeth, mucosa, existing implants, custom occlusal device, bone, or any combination thereof, could be used as an initial positioning mechanism to position surgical templates. Different anchoring mechanisms are then used to stabilize the surgical templates during surgery. In this report, a novel design of surgical templates using remaining dentition and opposing occlusal surfaces as initial positioning mechanism followed by the combination of bone block fixation screw and stainless‐steel beads as secondary anchoring mechanisms is described. The advantages, limitations, and comparisons with surgical templates using other anchoring mechanisms are also discussed.
How argumentation theory can inform assessment validity: A critical review
Authors: Kinnear Benjamin , Schumacher Daniel J. , Driessen Erik W. , Varpio Lara 
Published: July 2022

AbstractIntroductionMany health professions education (HPE) scholars frame assessment validity as a form of argumentation in which interpretations and uses of assessment scores must be supported by evidence. However, what are purported to be validity arguments are often merely clusters of evidence without a guiding framework to evaluate, prioritise, or debate their merits. Argumentation theory is a field of study dedicated to understanding the production, analysis, and evaluation of arguments (spoken or written). The aim of this study is to describe argumentation theory, articulating the unique insights it can offer to HPE assessment, and presenting how different argumentation orientations can help reconceptualize the nature of validity in generative ways.MethodsThe authors followed a five‐step critical review process consisting of iterative cycles of focusing, searching, appraising, sampling, and analysing the argumentation theory literature. The authors generated and synthesised a corpus of manuscripts on argumentation orientations deemed to be most applicable to HPE.ResultsWe selected two argumentation orientations that we considered particularly constructive for informing HPE assessment validity: New rhetoric and informal logic. In new rhetoric, the goal of argumentation is to persuade, with a focus on an audience's values and standards. Informal logic centres on identifying, structuring, and evaluating arguments in real‐world settings, with a variety of normative standards used to evaluate argument validity.DiscussionBoth new rhetoric and informal logic provide philosophical, theoretical, or practical groundings that can advance HPE validity argumentation. New rhetoric's foregrounding of audience aligns with HPE's social imperative to be accountable to specific stakeholders such as the public and learners. Informal logic provides tools for identifying and structuring validity arguments for analysis and evaluation.
Purple acid phosphatase2 stimulates a futile cycle of lipid synthesis and degradation, and mitigates the negative growth effects of triacylglycerol accumulation in vegetative tissues
Authors: Cai Yingqi , Zhai Zhiyang , Blanford Jantana , Liu Hui , Shi Hai , Schwender Jorg , Xu Changcheng , Shanklin John 
Published: July 2022

Summary

Storage lipids (mostly triacylglycerols, TAGs) serve as an important energy and carbon reserve in plants, and hyperaccumulation of TAG in vegetative tissues can have negative effects on plant growth. Purple acid phosphatase2 (PAP2) was previously shown to affect carbon metabolism and boost plant growth. However, the effects of PAP2 on lipid metabolism remain unknown.

Here, we demonstrated that PAP2 can stimulate a futile cycle of fatty acid (FA) synthesis and degradation, and mitigate negative growth effects associated with high accumulation of TAG in vegetative tissues. Constitutive expression of PAP2 in Arabidopsis thaliana enhanced both lipid synthesis and degradation in leaves and led to a substantial increase in seed oil yield.

Suppressing lipid degradation in a PAP2‐overexpressing line by disrupting sugar‐dependent1 (SDP1), a predominant TAG lipase, significantly elevated vegetative TAG content and improved plant growth. Diverting FAs from membrane lipids to TAGs in PAP2‐overexpressing plants by constitutively expressing phospholipid:diacylglycerol acyltransferase1 (PDAT1) greatly increased TAG content in vegetative tissues without compromising biomass yield.

These results highlight the potential of combining PAP2 with TAG‐promoting factors to enhance carbon assimilation, FA synthesis and allocation to TAGs for optimized plant growth and storage lipid accumulation in vegetative tissues.
The curious case of inability to open one eye after ipsilateral posterior superior alveolar nerve block
Authors: Singh Minerva , Kumar Jitender , Kumar Sanjeev 
Published: July 2022

AbstractIntroductionDental patients are usually concerned about the side effects of extraction of upper teeth on their eyes, however rare but certain ophthalmic complications corresponding to dental anaesthesia are well reported in literature.Material and MethodsWe present a case of 50‐year‐old female who developed ophthalmic complications following Posterior Superior Alveolar Nerve Block administration during extraction of left maxillary second molar.ResultsA clinical diagnosis of transient oculomotor palsy was made. Constant assurance about the transient nature of the symptoms was given to the patient. The patient started recovering after 30 min and recovered fully in about 2 h.Clinical significanceClinicians should be well aware of the ophthalmic effects of dental anaesthesia, this should always be kept in the back of mind that such complications are mostly transient but permanent loss of vision has also been documented in literature.
The Effects of Chronic Ankle Instability on the Biomechanics of the Uninjured, Contralateral Ankle During Gait
Authors: Ziaei Ziabari Elaheh , Haghpanahi Mohammad , Razi Mohammad , Lubberts Bart , Ashkani‐Esfahani Soheil , DiGiovanni Christopher W. 
Published: July 2022

AbstractObjectiveTo determine whether unilateral chronic ankle instability (CAI) affects the kinematics of the uninjured contralateral ankle.MethodsIn this case‐control study, 15 adult patients with unilateral CAI and 15 healthy controls were studied. Both the unstable and uninjured ankles in patients with unilateral CAI (CAI group, n = 15) were compared with that of healthy individuals (control group, n = 15). Applying body photo‐reflective markers, the participant's motion during gait was measured. Biomechanical variables including overall ankle‐toe angle, linear velocity, linear acceleration, angular velocity, angular acceleration, range of motion (RoM) in dorsiplantar flexion, and inversion‐eversion at initial contact, loading response, mid‐stance, terminal stance, pre‐swing, and swing phase of the gait were measured.ResultsIn patients with CAI, the injured and uninjured ankles were significantly different regarding angle‐toe angle, inversion‐eversion RoM, dorsiplantar flexion in mid‐stance, inversion‐eversion at initial contact and terminal stance as well as the pre‐swing and swing phases (p < 0.01). The uninjured ankles of patients showed lower ankle‐toe velocity (p = 0.01) and acceleration (p = 0.01) compared to both the left and right ankles of the controls. In addition, the uninjured ankles of the patients showed decreased ankle dorsiflexion and increased inversion during initial contact, loading response, mid‐stance, terminal stance, pre‐swing, and swing compared to the control group (p < 0.017).ConclusionThe results suggest that unilateral CAI can affect gait biomechanics in the contralateral uninjured ankle. Left unaddressed, unilateral CAI may lead to increased morbidity to the contralateral uninjured side. When surgery is not preferred for the management of unilateral CAI, rehabilitation protocols should focus on both sides.
Suicide plan prevalence, recurrence, and longitudinal association with nonfatal suicide attempt
Authors: Linthicum Kathryn P. , Ribeiro Jessica D. 
Published: July 2022

AbstractBackgroundEach year, millions of people develop suicide plans. These plans are assumed to indicate imminent suicide risk, yet this has rarely been tested. The present study seeks to address two questions: (1) how prevalent are specific thoughts of suicide plans among individuals with a history of suicidal thoughts and behaviors and (2) do suicide plans confer risk of future suicide attempts in the short term?MethodsSecondary data analysis was performed on a longitudinal dataset (N = 1021). Prevalence and frequencies of suicide planning features (i.e., method, time, place) at baseline and 3, 14, and 28 days post‐baseline were calculated. Logistic regressions were conducted to assess whether suicide plans confer risk of suicide attempts across a 28‐day follow‐up period.ResultsSuicide planning more commonly involved thoughts of method than place and/or time. High variability in suicide planning was evident and thoughts of suicide plans frequently recurred. Contrary to assumptions, suicide plans displayed weak associations with nonfatal suicide attempt across the 28‐day follow‐up period.ConclusionsSuicide plans appear heterogeneous in nature. They do not appear to play a strong role in predicting nonfatal suicide attempts. Re‐evaluation of the central role that suicide plans occupy within clinical risk assessments may be warranted.
Exchange rate regimes and current account persistence
Authors: Tseng Fu‐Min , Wu Jyh‐Lin 
Published: July 2022

AbstractWe empirically examine Friedman's hypothesis that floating exchange rates facilitate current account adjustments. The main innovation in the empirical analysis is to control for the sample selection bias. We provide robust evidence that current account persistence decreases with the flexibility of nominal exchange rate regimes and is significantly higher under hard pegs than under floating for industrial countries. The economic driving force of this finding is that the channel of the exchange rate adjustment mechanism dominates in affecting the real exchange rate persistence relative to its shock channel.
Differential impact of minimum unit pricing on alcohol consumption between Scottish men and women: controlled interrupted time series analysis
Authors: Rehm Jürgen , O'Donnell Amy , Kaner Eileen F S , Jane LLopis Eva , Manthey Jakob , Anderson Peter 
Published: July 2022

ObjectiveTo assess the immediate impact of the introduction of minimum unit pricing (MUP) in Scotland on alcohol consumption and whether the impact differed by sex, level of alcohol consumption, age, social grade and level of residential deprivation of respondents.DesignPrimary controlled interrupted time series analysis and secondary before-and-after analysis of the impact of introducing MUP in Scotland using alcohol consumption data for England as control.SettingData from Kantar Worldpanel’s Alcovision survey, a continuous retrospective online timeline follow-back diary survey of the previous week’s alcohol consumption.Participants53 347 women and 53 143 men.InterventionsIntroduction of a minimum price of 50 pence per UK unit (6.25 pence/g) for the sale of alcohol in Scotland on 1 May 2018.Main outcome measuresNumber of grams of alcohol consumed per week, in total, in off-trade (eg, at home) and in on-trade (eg, in pubs, restaurants).ResultsPrimary interrupted time series analyses found that the introduction of MUP was associated with a drop in reported weekly total alcohol consumption of 5.94 g (95% CI 1.29 to 10.60), a drop in off-trade consumption of 3.27 g (95% CI −0.01 to 6.56) and a drop in on-trade consumption of 2.67 g (95% CI −1.48 to 6.82). Associated reductions were larger for women than for men and were greater among heavier drinkers than for lighter drinkers, except for the 5% of heaviest drinking men for whom an associated increase in consumption was found. Secondary before-and-after analyses found that reductions in consumption were greater among older respondents and those living in less deprived areas. The introduction of MUP was not associated with a reduction in consumption among younger men and men living in more deprived areas.ConclusionsGreater policy attention needs to be addressed to the heaviest drinking men, to younger men and to men who live in more deprived areas.
Online queries as a criterion for evaluating epidemiological status and effectiveness of COVID-19 control measures in Russia: results from Yandex.Wordstat analysis
Authors: Momynaliev Kuvat , Khoroshun Dimash , Akimkin Vasiliy 
Published: July 2022

ObjectivesAssessment of the significance of online queries regarding smell impairment to evaluate the epidemiological status and effectiveness of COVID-19 epidemic control measures using levofloxacin as an example.SettingThere are 81 regions of Russia and several large cities, such as Moscow, St. Petersburg and Nizhny Novgorod.MethodsWeekly online queries from Yandex Russian users regarding smell impairment and levofloxacin were analysed in regions and large cities of Russia from 16 March 2020 to 21 February 2021.ResultsA strong positive direct correlation (r>0.7) was found between the number of smell-related queries in Yandex new cases of COVID-19 in 59 out of 85 Russian regions and large cities (70%). During the ‘first’ peak of COVID-19 incidence in Russia (April–May 2020), the increase in the number of smell-related queries outpaced the increase in new cases by 1–2 weeks in 23 out of 59 regions of Russia. During the ‘second’ peak of COVID-19 incidence in Russia (October–December 2020), the increase in the number of smell-related queries outpaced the increase in the number of new cases by 1–2 weeks in 36 regions of Russia, including Moscow. It was found that the query/new case ratio increased by more than 100% in 24 regions. The regions where the increase in queries was more than 160% compared with new infection cases during the ‘second’ peak of incidence demonstrated significantly higher search activity related to levofloxacin than the regions where the increase in queries was lower than 160% compared with the increase in new infection cases.ConclusionThe sudden interest in certain symptoms of COVID-19, such as smell impairment and the growing frequency of online queries among the population, can be used as an indicator of the spread of coronavirus infection among the population and for evaluation of the effectiveness of the COVID-19 epidemic control measures.
Resilience of family caregivers of people with dementia in South Korea: protocol for a scoping review
Authors: Seo Hyun-Ju , Choi Min-Jung , Park Song-I , Park Jeong-hwan 
Published: July 2022

IntroductionThe prevalence of dementia among the elderly population in South Korea was 9.94% in 2017, and the number of people living with dementia is estimated to increase up to one million by 2024. Considering that approximately 55%–85% of people with dementia are taken care of by family members in South Korea, the phenomenon of resilience for family caregivers with patients with dementia should be understood within a Korean cultural context. The purpose of this paper is to describe the protocol of a scoping review addressing the resilience of family caregivers for Koreans with dementia.Methods and analysisArksey and O'Malley’s scoping review framework and Joanna Briggs Institute’s manual for scoping reviews will guide the review methods. Multiple databases, including Ovid-MEDLINE, Ovid-EMBASE, PsycINFO, Cumulative Index for Nursing and Allied Health Literature and Korean databases will be identified using controlled vocabulary and text words. Two review authors will independently screen and select studies based on predefined eligible criteria. The extracted data will undergo descriptive analysis of the contextual data and a quantitative analysis using the appropriate descriptive statistics.Ethics and disseminationBecause the scoping review methodology consists of reviewing and collecting data from the published literature, this study does not require ethics approval. This scoping review will serve to highlight existing gaps within the literature to guide further research and to develop future strategies to measure and improve the resilience of family caregivers for patients with dementia in South Korea.