bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal evaluation of chromosomal abnormalities and copy number variations in fetuses with single umbilical artery
Authors: Han Shiyao , Feng Jianwei , Meng Xinyue 
Published: October 2022

AbstractBackground A normal umbilical cord has a single umbilical vein and two umbilical arteries. Single umbilical artery (SUA) is one of the most common umbilical anomaly detected by prenatal ultrasonography. The objective of this study was to evaluate the usefulness of copy number variation sequencing (CNV-seq) and standard karyotyping in fetuses with single umbilical artery (SUA) and to investigate the genetic etiology of prenatal SUA. Methods Data from pregnancies referred for invasive testing and copy number variation sequencing (CNV-seq) due to sonographic diagnosis of fetal with SUA from 2013 to 2022 were obtained retrospectively from the computerized database. The rates of chromosome aberrations and abnormal CNV-seq findings for isolated SUA, SUA accompanied with soft markers and ultrasound malformations were calculated. Results Of the 474 fetuses with SUA that underwent karyotyping, chromosomal abnormalities were detected in fetuses, with a chromosomal abnormality rate of 10.3% (49/474). The use of CNV-seq provides a 10.2% (18/177) incremental yield of detecting pathogenic CNVs in fetuses with SUA and normal karyotype. our study showed that the risk of pathogenic chromosomal abnormalities and copy number variations were increased in the SUA combined malformation or soft markers group compared to that in the isolated SUA group.Meanwhile, fetuses with isolated SUA had an additional 3.4% (6/177) of pathogenic CNVs on top of chromosome aneuploidies. Conclusion CNV-seq could aid in the risk assessment and genetic counseling in fetuses with isolated SUA, Integrating CNV analysis and karyotyping for prenatal diagnosis of SUA in prenatal diagnosis can provide more accurate genetic proof for prenatal counseling and prediction of fetal outcomes.
3D structure of the Campi Flegrei caldera central sector reconstructed through short-period magnetotelluric imaging
Authors: Troiano Antonio , Giuseppe Maria Giulia Di , Isaia Roberto 
Published: October 2022

Abstract
The Campi Flegrei caldera experienced an unrest phase dating to 2005, which primary expression is the impressive ground uplift, accompanied by increasing degassing and seismic activities. Such last two phenomena developed mainly in the caldera central sector, including the Solfatara – Pisciarelli complex. However, the inner structure of such an area is still not defined, and this originates a poor understanding of the ongoing unrest. This paper describes the results of a new magnetotelluric survey performed in the Campi Flegrei caldera central sector. Through the inversion of data collected in 47 independent soundings, a 3D model of the electrical resistivity has been retrieved, which evidenced a partition of the investigated structure. The Agnano – Astroni area seems to be associated with a liquid-dominated geothermal reservoir, whereas the Solfatara – Pisciarelli area seems to be characterized by a single mixed liquid and gasses -dominated geothermal reservoir, which supplies the main caldera fumaroles. The proposed reconstruction of the geometrical characteristics of the hydrothermal system and the primary fluid rising pathways gives substantial clues about the significance of the detected structures in the evolution of the caldera unrest.
A Prototype For Quantum Database In Hybrid Quantum: A Complete Ecosystem
Authors: CHAKRABORTY SAYANTAN 
Published: October 2022

Abstract
This study proposes a prototypeAnd a possibility to converge both this quantum database and classical database. This study mostly identifies the gap between this classical database and quantum database and it proposes a hypothesis and prototype which can be implemented in future products. It is a way that can be used in future industrial product development on hybrid quantum computers. The existing concept used to consider oracle as a black box this study opens up the possibility for the quantum industry to develop the QASAM module so that we can develop a fully quantum database instead of using a classical database as BlackBox.As the Toffoli gate is basically an effective NAND gate it is possible to run any algorithm theoretically in quantum computers. So we will propose a logical design for memory management for the quantum database, security enhancement model, Quantum Recovery Manager & automatic storage management model and more for the quantum database which will ensure the quantum advantages.In this study, we will also explain the Quantum Vector Database as well as the possibility of improvement in duality quantum computing.It opens up a new scope, possibilities and research area in a new approach for quantum database and duality quantum computing.
Busy periods for queues alternating between two modes
Authors: Kleiner Igor , Frostig Esther , Perry David 
Published: October 2022

Abstract
We study the busy period of a single server queueing systemoperating in two alternating modes - working and vacation. In the two modes the systems run as an MX/G/1 queue with disasters, but with different parameters. The vacation mode starts once the number of customers drops to zero. It is terminated randomly (when it is not empty) with a transition to the working mode. At such a transition moment all the customers are transferred to the working mode; the service of the customer being served is lost and it starts from scratch in the working mode. Every busy period starts with a batch arrival into an empty system and terminates at the first time that the number of customers drops to zero. The working and the vacation periods are analyzed too. Finally, we apply the results to obtain the probability generating functions of the number of customers in the working, as well as in the vacation periods.
A DFT/TDDFT investigation on chromone derivatives: fluorescence and electronic properties
Authors: Huang Pei , Lu Jiufu , Jin Lingxia , Liu Ernu , Li Li 
Published: October 2022

Abstract
The development of quick and precise detection technologies for active compounds in vivo is critical for disease prevention, diagnosis, and pathological investigation. The fluorescence signal of the fluorophore usually defines the probe's sensitivity to the chemical being examined. Many natural compounds containing flavone and isoflavone scaffolds exhibit a certain amount fluorescence, albeit with poor fluorescence quantum yields. Therefore, we used density functional theory (DFT) and time-dependent density functional theory (TDDFT) calculations to investigate the fluorescence characteristics of chromium-derived fluorophores in more depth. Different substituents are introduced at different positions of the chromone. As weak electron donor groups, alkyl and aromatic groups were discovered to have varying quantum yields on the fluorophore scaffold, and longer alkyl chains are favorable to enhance fluorescence quantum yield. In comparison to the amino group, substituted amino group can avoid group rotation, and the introduction of cyclic amines such as pyrrolidine and heterocyclic amines can improve optical characteristics. The electron-donating methoxy group at position 6 helps to increase the fluorescence quantum yield.
Clinical significance of reactive thrombocytosis in the course of acute pancreatitis
Authors: Chiba Nobutaka , Sugita Atsunori , Mizuochi Minori , Sato Jun , Saito Takeshi , Sakurai Atsushi , Kinoshita Kosaku 
Published: October 2022

Abstract
Background
Reactive thrombocytosis occurs secondary to systemic infections, inflammatory, and other conditions. The relationship between thrombocytosis and acute pancreatitis (AP) in inflammatory diseases is uncertain. This study aimed to evaluate the clinical significance of thrombocytosis in AP patients during hospitalization.
Methods
Subjects within 48 hours of AP onset were consecutively enrolled over 6 years. Platelet counts of ≥ 450,000/µL were defined as thrombocytosis, < 100,000/µL as thrombocytopenia, and other counts as normal. We compared clinical characteristics, including the rate of Severe AP (SAP) assessed by the Japanese Severity Score; blood markers, including hematologic and inflammatory factors and pancreatic enzymes during hospitalization; and pancreatic complications and outcomes in the three groups.
Results
A total of 108 patients were enrolled. Although, SAP was more common in patients with thrombocytosis and thrombocytopenia (87.9% and 100%, respectively), the differences in lymphocytes and C-reactive protein, lactase dehydrogenase, or antithrombin levels, which are factors of the systemic inflammatory response, and mean platelet volume, an indicator of platelet activation were observed among patients with thrombocytosis and thrombocytopenia during hospitalization. Regarding pancreatic complications and outcomes, patients with thrombocytosis and thrombocytopenia had higher acute necrotic collection (ANC), pancreatic necrosis, intestinal paralysis, respiratory dysfunction, and pancreatic-related infection levels than those in patients with normal platelet levels. The relationship between pancreatic complications and thrombocytosis was assessed by multivariate logistic regression; the odds ratios for the development of ANC, pancreatic necrosis and pancreatic-related infections were 7.360, 3.735 and 9.815, respectively.
Conclusions
Thrombocytosis during hospitalization for AP suggested the development of local pancreatic complications and pancreatic-related infections.
TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer
Authors: Zhong Tian , Zhang Jing , Liu Xingren , Li Hongmin 
Published: October 2022

Abstract
Cisplatin (CDDP)-based chemotherapy is commonly used to treat advanced non-small cell lung cancer (NSCLC). However, the efficacy is limited by the development of drug resistance. Tripartite motif (TRIM) proteins typically have E3 ubiquitin ligase activities and modulate protein stability. In the present study, we screened for chemosensitivity-regulating TRIM proteins using CDDP-resistant NSCLC cell lines. We show that TRIM17 is upregulated in CDDP-resistant NSCLC cells and tumors compared to CDDP-sensitive counterparts. NSCLC patients with high TRIM17 expression in tumors have shorter progression-free survival than those with low TRIM17 expression after CDDP chemotherapy. Knockdown of TRIM17 increases the sensitivity of NSCLC cells to CDDP both in vitro and in vivo. In contrast, overexpression of TRIM17 promotes CDDP resistance in NSCLC cells. TRIM17-mediated CDDP resistance is associated with attenuation of reactive oxygen species (ROS) production and DNA damage. Mechanistically, TRIM17 interacts with RBM38 and promotes K48-linked ubiquitination and degradation of RBM38. TRIM17-induced CDDP resistance is remarkably reversed by RBM38. Additionally, RBM38 enhances CDDP-induced production of ROS. In conclusion, TRIM17 upregulation drives CDDP resistance in NSCLC largely by promoting RBM38 ubiquitination and degradation. Targeting TRIM17 may represent a promising strategy for improving CDDP-based chemotherapy in NSCLC.
Effects of temperature and light on the stability of the blast effector complex APikL2A/sHMA25 as determined by molecular dynamic analyses
Authors: Zhao Ling , Zhang Ting , Luo Yanjie , Li Lin , Cheng Ruhong , Shi Zhigang , Wang Genping , Ren Tiancong 
Published: October 2022

Abstract
Magnaporthe oryzae is the causal agent of rice blast. Understanding how abiotic stress affects the resistance of plants to this disease is useful for designing disease control strategies. Here, the effects of temperature and light (supplied under an oscillating electric field) on the effector complex comprising APikL2A from M. oryzae and sHMA25 from foxtail millet were investigated by molecular dynamic (MD) simulations using the GROMACS package. While the structure of APikL2A/sHMA25 remained relatively stable in a temperature range from 290 K (16.85°C) to 320 K (46.85°C), the dome shape of the temperature-dependent binding free energy curve indicated that there was minimum binding affinity between APikL2A and sHMA25 at 300 K – 310 K. This coincided with the optimum infectivity temperature, suggesting that decoupling of the two polypeptides may play a role in the infection process. A strong oscillating electric field destroyed the structure of APikL2A/sHMA25, although it was stable under weaker electric fields. An increase in binding free energy was discovered in these electric field-dependent simulations.
The intensity of eco-environmental constraints and green innovation efficiency
Authors: Wu Mingran 
Published: October 2022

Abstract
In this study, a spatial econometric model was constructed by combining the intensity of eco-environmental constraints, the efficiency of green innovation and a series of high-quality economic development indicators. The impact of environmental constraint intensity on green innovation efficiency was empirically analysed on Chinese provincial panel data, and the impact was decomposed into direct and indirect (spillover). The results showed that (1) from 2011 to 2020, the overall performance of China's green innovation efficiency was relatively fine, and the efficiency value has been greatly improved in the later stage, especially in 2020. In addition, regional green innovation performance was positively correlated with economic development. (2) The strengthening of eco-environmental constraints was not conducive to the improvement of regional green innovation efficiency, but the scale and agglomeration effect of industrial enterprises and the increase in foreign trade activities were conducive to efficiency improvement. (3) The direct effect of eco-environmental constraints and firm size on green innovation efficiency in this region was positive, while the indirect effect and total effect were negative. The direct effect of investment openness and industrial agglomeration degree was negative, while the indirect effect and total effect were positive. All effects of industrial structure were 0. Therefore, the government needs to set up reasonable methods of environmental regulation, complete and optimize the industrial chain, and formulate reasonable regional development plans.
Application of Surface-To-Roadway TEM for detecting deep aquifer in Coal Field, an example from North China
Authors: Chen Weiying , Xue Guoqiang , Yu Jincun , Lei Kangxin , Song Wanting 
Published: October 2022

Abstract
Transient electromagnetic methods (TEM) are effective tools for the hydrogeological investigations of coal mines. However, the traditional ground-based and underground-based TEMs typically fail to detect the deeply buried water-bearing bodies in the majority of coal mines in northern China, where the quaternary overburden is generally thick and many aquifers exist. In the present study, a surface-to-roadway TEM was proposed which utilized grounded-wire sources to transmit signals with large moments on the surface, and required receivers which had the ability to record signals with high resolution in underground mining roadways. First of all, the proposed device was introduced. Subsequently, a synthetic model was established based on the existing information of Zhuxianzhuang coal field in Anhui Province, China, along with the analysis of forward and inversion results. Finally, the acquisition and processing of field data were conducted. Both the synthetic and field results demonstrated the feasibility and superiority of the proposed method. The deeply buried aquifers were able to be better characterized by the surface-to-roadway configuration than the ground-based surveys.
Identification and genetic characterization of a new totivirus from Bursera graveolens in western Ecuador
Authors: Cornejo Juan Francisco , Alvarez Robert , Mollov Dimitre , Quito-Avila Diego 
Published: October 2022

Abstract
The complete genomic sequence of a previously uncharacterized virus provisionally named Bursera graveolens totivirus 1 (BgTV-1) was obtained from Bursera graveolens (Kunth) Triana & Planch., a tree known as “palo santo” in Ecuador. The BgTV-1 genome is monopartite double-stranded RNA (dsRNA) and 4,794 nucleotides (nt) long (GenBank accession number ON988291). Phylogenetic analysis of the capsid protein (CP) and RNA-dependent-RNA-polymerase (RdRp) placed BgTV-1 in a clade with other plant-associated totiviruses. Amino acid (aa) sequence comparisons of BgTV-1 putative proteins showed the highest identities to those of taro-associated totivirus L (QFS21890.1-QFS21891.1) and Panax notoginseng virus A (YP_009225664.1- YP_009225665.1) with 51.4% and 49.8%, for the CP, and 56.4% and 55.2% for the RdRp, respectively. BgTV-1 was not detected in any of the two endophytic fungi grown in BgTV-1-positive B. graveolens leaves, suggesting a plant totivirus. Based on distinct host and low aa identities between the CP of BgTV-1 and counterparts from closest relatives, the virus described in this study should be assigned as a new member of the genus Totivirus.
Astrocytic Cebpd Regulates Pentraxin 3 Expression to Promote Fibrotic Scar Formation after Spinal Cord Injury
Authors: Wang Shao-Ming , Hsu Jung-Yu C , Ko Chiung-Yuan , Wu Hsiang-En , Hsiao Yu-Wei , Wang Ju-Ming 
Published: October 2022

Abstract
Astroglial-fibrotic scars resulted from spinal cord injury affect motor and sensory function, leading to paralysis. In particular, the fibrotic scar is a main barrier that disrupts neuronal regeneration after spinal cord injury. However, the association between astrocytes and fibrotic scar formation is not yet understood. We have previously demonstrated that the transcriptional factor Cebpd contributes to astrogliosis, which promotes glial scar formation after spinal cord injury. Herein, we show that fibrotic scar formation was decreased in the epicentre region in Cebpd−/− mice after contusive spinal cord injury and astrocytic Cebpd promoted fibroblast migration through secretion of Ptx3. Furthermore, the expression of Mmp3 was increased under recombinant protein Ptx3 treatment in fibroblasts by observing microarray data, resulting in fibroblast migration. In addition, regulation of Mmp3 occurs through the NFkB signaling pathway by using an irreversible inhibitor of IκBα phosphorylation in pretreated fibroblasts. Of note, we used the synthetic peptide RI37, which blocks fibroblast migration and decreases fibroblast Mmp3 expression in IL-1b-treated astrocyte conditioned media. Collectively, our data suggest that fibroblast migration can be affected by astrocytic Cebpd through the Ptx3/NFkB/Mmp3 axis pathway and that the RI37 peptide may act as a therapeutic medicine to inhibit fibrotic scar formation after spinal cord injury.
Periodic solutions of a class of indefinite singular differential equations
Authors: Liang Zaitao , Zhang Xiuqiang 
Published: October 2022

Abstract
In this paper, we establish some sufficient conditions for the existence of positive periodic solutions of a more general indefinite singular differential equation. Our results are applicable to the case of a strong singularity as well as the case of a weak singularity. Recent results in the literature are generalized and improved.
2020 MSC: 34C25
Establishment of CRISPR-Cas9 system in Bifidobacteria animalis AR668
Authors: Li Jiao , Song Xin , Xiong Zhiqiang , Wang Guangqiang , Xia Yongjun , Yang Yijin , Ai Lianzhong 
Published: October 2022

Abstract
Bifidobacteria are representative intestinal probiotics that have extremely high application value in the food and medical fields. However, the lack of molecular biology tools limits the research on functional genes and mechanisms of bifidobacteria. The application of accurate and efficient CRISPR system to genome engineering can fill the gap in efficient genetic tools for bifidobacteria. In this study, CRISPR system of B. animalis AR668 was established, which successfully knocked out gene 0348and gene 0208. The influence of different homology arms and fragments on the knockout effect of the system was explored. In addition, the inducible plasmid curing system of bifidobacteria was innovatively established. This study contributes to the genetic modification and functional mechanism analysis of bifidobacteria.
Personalized Federated Learning with Model Interpolation among Client Clusters and its Application in Smart Home
Authors: Yang Zhikai , Liu Yaping , Zhang Shuo , Zhou Keshen 
Published: October 2022

Abstract
The proliferation of high-performance personal devices and the widespread deployment of machine learning (ML) applications have led to two consequences: the volume of private data from individuals or groups has exploded over the past few years; and the traditional central servers for training ML models have experienced communication and performance bottlenecks in the face of massive amounts of data. However, this reality also provides the possibility of keeping data local for ML training and fusing models on a broader scale. As a new branch of ML application, Federated Learning (FL) aims to solve the problem of multi-party joint learning on the premise of protecting personal data privacy. However, due to the heterogeneity of devices, including network connection, network bandwidth, computing resources, etc., it is unrealistic to train, update and aggregate models in all devices in parallel, while personal data is often not independent and identically distributed (Non-IID) due to multiple reasons. This reality poses a challenge to the speed and convergence of FL. In this paper, we propose the pFedCAM algorithm, which aims to improve the robustness of the FL system to device heterogeneity and Non-IID data, while achieving some degree of federation model personalization. pFedCAM is based on the idea of clustering and model interpolation by classifying heterogeneous clients and performing FedAvg algorithm in parallel, and then combining them into personalized federated global models by inter-cluster model interpolation. Experiments show that the accuracy of pFedCAM improves 10.3% on Fashion-MNIST and 11.3% on CIFAR-10 compared to the benchmark in the case of Non-IID data. In the end, we applied pFedCAM to HomeProtect, a smart home privacy protection framework we designed, and achieved good practical results in the case of flame recognition.
Fault-tolerant quantum anonymous communication protocols against collective noise
Authors: Liang Xiang-qian , Liu Bing-xin , Xu Guang-bao , Jiang Dong-huan , Liang An-hui 
Published: October 2022

Abstract

Considering the influence of collective-dephasing (C-D) noise and collective-rotation (C-R) noise, by utilizing controlled-NOT operation, controlled-Z operation and other unitary operations, we proposed the fault-tolerant quantum protocols to realize the quantum anonymous communication against C-D noise and C-R noise, respectively. Correctness analysis shows that the encrypted quantum states can not be affected by the collective noise. Security analysis shows that the protocols can ensure the anonymity of the sender and receiver and privacy of quantum information.
Positive periodic solutions for a second-order singular differential equation with two indefinite weights
Authors: Cheng Zhibo , Song Juan , Xin Yun 
Published: October 2022

Abstract
This paper aims to show that the fixed point theorem of cone mapping can be applied to a second-order singular differential equation with two indefinite weights. Applying the positiveness of Green'sfunction of a second-order linear nonhomogeneous differential equation, we prove the existence of a positive periodic solution fora second-order singular differential equation with two indefinite weights.
MSC— 34B16; 34B18; 34C25.