bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fixed-loop vs. adjustable-loop cortical button devices for femoral fixation in ACL reconstruction – a systematic review and meta-analysis
Authors: Elmholt Simone Birkebæk , Nielsen Torsten Grønbech , Lind Martin 
Published: October 2022

Abstract
Purpose
Button implants with either a fixed-loop device (FLD) or adjustable-loop device (ALD) are used frequently in Anterior Cruciate Ligament Reconstruction (ACLR). Since revision ACLR is associated with poorer clinical outcomes, it is important to investigate the difference in risk of revision between FLDs and ALDs. Therefore, this paper aims to systematically assess the risk of revision ACLR between ALDs and FLDs as well as secondary outcomes such as knee stability and patient reported outcomes (PROMs).

Methods
The online databases Embase, Medline (PubMed), and SPORTDiscus were searched, comparing FLDs and ALDs for femoral fixation in patients undergoing primary ACLR with hamstring autografts. Risk of bias was assessed with the ROBINS-I tool for non-randomised studies. Due to heterogeneity a meta-analysis on revision rates were not possible. A random-effect meta-analysis was performed for the secondary outcomes and the quality of evidence was evaluated using the GRADE approach.

Results
Fifteen cohort studies with a total of 2686 patients were included. None of the studies found a clinical difference between ALDs and FLDs in either revision rates, knee stability or PROMS. However, the quality of evidence was graded “very low” due to study designs, risk of bias, and heterogeneity.

Conclusion
Studies of better quality are needed to investigate the risk of revision ACLR between ALDs and FLDs. There was no difference in knee stability and PROMs between the ALDs and FLDs; however, the interpretation of these results is challenging due to low quality of evidence.

Level of evidence
Level III.
The effect of the capitation policy withdrawal on maternal health service provision in Ashanti Region, Ghana: an interrupted time series analysis
Authors: Yambah John Kanyiri , Mensah Kofi Akohene , Kuunibe Naasegnibe , Laar Kindness , Atinga Roger Ayimbillah , Ofori Boateng Millicent , Opoku Daniel , Quentin Wilm 
Published: October 2022

Abstract
Background
Payment methods are known to influence maternal care delivery in health systems. Ghana suspended a piloted capitation provider payment system after nearly five years of implementation. This study aimed to examine the effects of Ghana’s capitation policy on maternal health care provision as part of lesson learning and bridging this critical literature gap.

Methods
We used secondary data in the District Health Information Management System-2 and an interrupted time series design to assess changes in level and trend in the provision of ANC4+ (visits of pregnant women making at least the fourth antenatal care attendance per month), HB36 (number of hemoglobin tests conducted for pregnant women who are at the 36th week of gestation) and vaginal delivery in capitated facilities-CHPS (Community-based Health Planning and Services) facilities and hospitals.

Results
The results show that the capitation policy withdrawal was associated with a statistically significant trend increase in the provision of ANC4+ in hospitals (coefficient 70.99 p < 0. 001) but no effect in CHPS facilities. Also, the policy withdrawal resulted in contrasting effects in hospitals and CHPS in the trend of provision of Hb36; a statistically significant decline was observed in CHPS (coefficient − 7.01, p < 0.05) while that of hospitals showed a statistically significant trend increase (coefficient 32.87, p < 0.001). Finally, the policy withdrawal did not affect trends of vaginal delivery rates in both CHPS and hospitals.

Conclusions
The capitation policy in Ghana appeared to have had a differential effect on the provision of maternal services in both CHPS and hospitals; repressing maternal care provision in hospitals and promoting adherence to anemia testing at term for pregnant women in CHPS facilities. Policy makers and stakeholders should consider the possible detrimental effects on maternal care provision and quality in the design and implementation of per capita primary care systems as they can potentially impact the achievement of SDG 3.
Optimization and application of UVC irradiation for prevention of fungal biodeterioration of vegetable tanned and chrome tanned leather
Authors: Jhahan Eshita , Bhattacharyya Subarna , Chaudhuri Anirban , Sarkar Nirmal , Akhtar Shaheen , Chaudhuri Punarbasu 
Published: October 2022

AbstractUV-C irradiation critically effects the growth of micro-fungi and also deteriorate leather materials. In the present study vegetable tanned and chrome tanned leather were infected with pure cultures of Aspergillus niger and Aspergillus flavus, which were isolated from stored leather materials. UV-C light (λ = 254 nm) was applied on infected leather for 15 and 60 min. The changes in leather qualities were examined through weight, tensile strength, scanning electron microscope, energy dispersive X-ray and Fourier transform infrared spectroscopy study after 15 and 30 days of fungal inoculation. Vegetable tanned leather was more vulnerable in case of fungal attack than chrome tanned leather while A. flavus showed more influence on leather deterioration than A. niger. The results showed that weight loss after 30 days for 15 and 60 min irradiation exposure was 1.3% compared to A. flavus infected leather (3.93%). The tensile strength of vegetable and chrome tanned UV irradiated leather was increased by 44% and 7% respectively. The scanning electron microscopic images exhibit the limited presence of conidiophores in UV-C exposed leather which confirmed the potentiality of irradiation for controlling fungal growth. The infrared spectral analysis of UV-C exposed infected leather samples showed neither shifting of wavenumber nor displacement of any functional groups. Altogether the efficacy of UV-C irradiation against biodeterioration of leather was concluded to be effective. This method can be used to control fungal growth without compromising the leather quality.
Graphical Abstract
Head to toe ultrasound: a narrative review of experts’ recommendations of methodological approaches
Authors: Messina Antonio , Robba Chiara , Bertuetti Rita , Biasucci Daniele , Corradi Francesco , Mojoli Francesco , Mongodi Silvia , Rocca Eduardo , Romagnoli Stefano , Sanfilippo Filippo , Vetrugno Luigi , Cammarota Gianmaria 
Published: October 2022

AbstractCritical care ultrasonography (US) is widely used by intensivists managing critically ill patients to accurately and rapidly assess different clinical scenarios, which include pneumothorax, pleural effusion, pulmonary edema, hydronephrosis, hemoperitoneum, and deep vein thrombosis. Basic and advanced critical care ultrasonographic skills are routinely used to supplement physical examination of critically ill patients, to determine the etiology of critical illness and to guide subsequent therapy. European guidelines now recommend the use of US for a number of practical procedures commonly performed in critical care. Full training and competence acquisition are essential before significant therapeutic decisions are made based on the US assessment. However, there are no universally accepted learning pathways and methodological standards for the acquisition of these skills.Therefore, in this review, we aim to provide a methodological approach of the head to toe ultrasonographic evaluation of critically ill patients considering different districts and clinical applications.
Magnetotelluric data denoising method combining two deep-learning-based models
Authors: Li Jin , Liu Yecheng , Tang Jingtian , Peng Yiqun , Zhang Xian , Li Yong 
Published: October 2022

The magnetotelluric (MT) data collected in an ore-concentration area are extremely vulnerable to all kinds of noise pollution. However, separating real MT signals from strong noise is still a difficult problem, and the noise in MT data is quite distinct from clean data in morphological features. By performing the signal-noise identification and data prediction, we develop a deep learning method to denoise MT data containing strong noise. First, we use the convolutional neural network (CNN) to learn the feature differences between the samples of massive noise and clean data and use the learned features to realize signal-noise identification of the measured data. Second, we use the measured clean data obtained by CNN identification to train the long short-term memory (LSTM) neural network and perform the prediction denoising of the noisy data. The simulation results clearly demonstrate the following two facts: (1) the predicted data output from LSTM basically matches the time-frequency domain features of the real data and (2) our CNN method performs significantly better than the features parameter classification method in dealing with signal-noise identification. In addition, the validity of our method is verified by the processing results of the measured data.
Implications of static low-frequency model on seismic geomechanics inversion
Authors: Sharifi Javad 
Published: October 2022

I have developed a novel insight into the differences between static and dynamic moduli and their effects on the performance of seismic geomechanics inversion. This achievement is obtained from triaxial deformation tests and ultrasonic measurements on core plugs and reveals that the static Young’s modulus deviates from the dynamic one in porous media, especially in particular ranges of depth and pressure, although conventional regression relationships suggest the opposite, i.e., similar trends for the static and dynamic Young’s moduli. Next, a novel simple approach is formulated to incorporate laboratory information directly into a seismic low-frequency model (LFM) using an artificial neural network to achieve a static low-frequency model (SLFM). Respecting the critical role of the LFM in the reliability of seismic inversion, any modification to the process of building this model can contribute to higher accuracy of the subsequent seismic geomechanics modeling. For this, LFMs are built using static and dynamic data before proceeding to seismic inversion to derive 3D cubes of static Young’s and bulk moduli. The results are successfully validated using data from known wells as well as a blind well. The modeling outcomes demonstrate that the seismic inversion based on the dynamic low-frequency model (DLFM) would return the same results for static and dynamic bulk moduli. In contrast, the results are erroneous for the static Young’s modulus when the conventional DLFM was adopted. Accordingly, the intelligent approach to static low-frequency modeling is found to be a good interpolation technique for estimating geomechanical parameters, as indicated by the good agreement between the static data and the corresponding inversion results at the well locations. My findings place emphasis on the necessity of reconsidering the relationship between the static and dynamic Young’s moduli and highlight the advantage of using an SLFM to increase the accuracy of geomechanical modeling.
Channel connection and stimulated reservoir volume estimation derived by the timing, location, and focal mechanism of microseismic events
Authors: Liu Lei , Song WeiQi , Yang XiaoHui , Zhou DeShan , Dong Lin , Hu JianLin 
Published: October 2022

Understanding and modeling channels of high-pressure liquids during hydraulic fracturing and stimulated reservoir volume (SRV) estimation are critical for the evaluation of the fracturing effect and the prediction of oil and gas production in unconventional (low permeability and porosity) reservoirs. In this study, we developed a “focal mechanism-to-event” channel connection criterion based on the timing, location, and focal mechanism of microseismic events, enabling the channel to be perpendicular or parallel to the fracturing plane and more in line with the mechanical properties of rock rupture. We first evaluated the two endpoints of all channels as a set of spatial points, followed by the application of the alpha-shape method to detect the concave hull shape boundary formed by the spatial points. Finally, we calculated the SRV by combining the shapes of the concave hull and Delaunay triangulation. In the experimental simulation, we found that this method could effectively calculate the hull volume, and the detected concave hull included all microseismic events and channels. Ultimately, we applied the channel connection criterion and SRV estimation method to a stage of 3.18 h real fracturing data containing 216 microseismic events. The final calculation revealed a total of 410 connection channels and 4.3154 × 105 m3 SRV, which is more consistent with the expected than the “event-to-event” or “event-to-channel” connection criteria and bin or convex hull SRV calculation methods.
The mental health associations of vitiligo: UK population-based cohort study
Authors: Thompson Andrew R. , Eleftheriadou Viktoria , Nesnas John 
Published: October 2022

Background
Vitiligo is an acquired, autoimmune depigmenting skin disorder that may affect psychological well-being.

Aims
To determine the risk and impact of psychological comorbidity in people with new-onset vitiligo.

Method
We conducted a retrospective observational study, using UK general practice data (2004–2020). Adults diagnosed with vitiligo (n = 7224) were matched 1:4 with controls (n = 28 880). Associations within 2 years of diagnosis were assessed for psychological conditions: recurrent depressive disorder (RDD), depressive episodes, non-phobia-related anxiety disorder, social phobia, adjustment disorder, substance misuse, self-harm and suicide attempts. Healthcare utilisation, time off work and unemployment within 1 year were compared in those with and without a mental health condition at vitiligo diagnosis.

Results
At diagnosis, people with vitiligo had a similar prevalence of mental health conditions as controls, except for anxiety disorder (cases 7.9%, controls 7.0%; P = 0.014). Incident RDD and anxiety disorder were more common in people with vitiligo (RDD: adjusted hazard ratio (aHR) 1.25, 95% CI 1.01–1.55; anxiety disorder: aHR 1.23, 95% CI 1.00–1.51). Risk was highest in Black and minority ethnic individuals (RDD: aHR 1.72, 95% CI 1.06–2.79; depressive episodes: aHR 1.56, 95% CI 1.03–2.37). No association was found with other mental health conditions. People with vitiligo and psychological comorbidity had more primary care encounters, more time off workand higher unemployment.

Conclusions
People with vitiligo have a higher incidence of RDD and anxiety disorder than controls, and this risk increase may be greatest in Black and minority ethnic populations.
Clinical decision-making style preferences of European psychiatrists: Results from the Ambassadors survey in 38 countries
Authors: Rojnic Kuzman Martina , Slade Mike , Puschner Bernd , Scanferla Elisabetta , Bajic Zarko , Courtet Philippe , Samochowiec Jerzy , Arango Celso , Vahip Simavi , Taube Maris , Falkai Peter , Dom Geert , Izakova Lubomira , Carpiniello Bernardo , Bellani Marcella , Fiorillo Andrea , Skugarevsky Oleg , Mihaljevic-Peles Alma , Telles-Correia Diogo , Novais Filipa , Mohr Pavel , Wancata Johannes , Hultén Martin , Chkonia Eka , Balazs Judit , Beezhold Julian , Lien Lars , Mihajlovic Goran , Delic Mirjana , Stoppe Gabriela , Racetovic Goran , Babic Dragan , Mazaliauskiene Ramune , Cozman Doina , Hjerrild Simon , Chihai Jana , Flannery William , Melartin Tarja , Maruta Nataliya , Soghoyan Armen , Gorwood Philip 
Published: October 2022

AbstractBackgroundWhile shared clinical decision-making (SDM) is the preferred approach to decision-making in mental health care, its implementation in everyday clinical practice is still insufficient. The European Psychiatric Association undertook a study aiming to gather data on the clinical decision-making style preferences of psychiatrists working in Europe.MethodsWe conducted a cross-sectional online survey involving a sample of 751 psychiatrists and psychiatry specialist trainees from 38 European countries in 2021, using the Clinical Decision-Making Style – Staff questionnaire and a set of questions regarding clinicians’ expertise, training, and practice.ResultsSDM was the preferred decision-making style across all European regions ([central and eastern Europe, CEE], northern and western Europe [NWE], and southern Europe [SE]), with an average of 73% of clinical decisions being rated as SDM. However, we found significant differences in non-SDM decision-making styles: participants working in NWE countries more often prefer shared and active decision-making styles rather than passive styles when compared to other European regions, especially to the CEE. Additionally, psychiatry specialist trainees (compared to psychiatrists), those working mainly with outpatients (compared to those working mainly with inpatients) and those working in community mental health services/public services (compared to mixed and private settings) have a significantly lower preference for passive decision-making style.ConclusionsThe preferences for SDM styles among European psychiatrists are generally similar. However, the identified differences in the preferences for non-SDM styles across the regions call for more dialogue and educational efforts to harmonize practice across Europe.
A Novel Bootstrapping Test for Analytical Biosimilarity
Authors: Zahel Thomas 
Published: October 2022

AbstractShowing analytical similarity is key to license biosimilar products with reduced or circumvented clinical effort. Statistical procedures to assess analytical similarity of quality attributes at drug product level have been highly debated by academia, industry, and regulatory agencies. In the past, a tiered approach was recommended by regulators, consisting of equivalence tests and quality range tests. However, this approach has recently been withdrawn by FDA. New guidelines of FDA and EMA favour the usage of quality range tests. Moreover, it has recently been shown that simple range tests, such as the 3SD test, are flawed, since they do not control the agency risk of falsely declaring a non-biosimilar product as being biosimilar (Type I error). This has also been highlighted by regulators recently. In this contribution, we developed a novel bootstrapping test for assessing analytical similarity that overcomes current flaws of equivalence and range tests. The developed test shows the desired properties, that is, (i) similarity conditions can be easily defined, (ii) differences of mean and the variance between the biosimilar and the innovator can be studied simultaneously, and (iii) the Type I error of the test can be controlled at a low level, e.g. 5%, evenly along the entire similarity condition. Moreover, the test shows up to 10% higher mean power values in the similarity region compared to existing range tests that aim to control the Type I error. Hence, this test is superior to existing quality range tests and is perceived compliant with current regulatory requirements.
Reproductive Phenotypes and Genotypes in Men With IHH
Authors: Dwyer Andrew A , Stamou Maria I , Anghel Ella , Hornstein Shira , Chen Danna , Salnikov Kathryn B , McDonald Isabella R , Plummer Lacey , Seminara Stephanie B , Balasubramanian Ravikumar 
Published: October 2022

Abstract

Context
Isolated hypogonadotropic hypogonadism (IHH) is phenotypically and genetically heterogeneous.

Objective
This work aimed to determine the correlation between genotypic severity with pubertal and neuroendocrine phenotypes in IHH men.

Methods
A retrospective study was conducted (1980-2020) examining olfaction (Kallmann syndrome [KS] vs normosmic IHH [nHH]), baseline testicular volume (absent vs partial puberty), neuroendocrine profiling (pulsatile vs apulsatile luteinizing hormone [LH] secretion), and genetic variants in 62 IHH-associated genes through exome sequencing (ES).

Results
In total, 242 men (KS: n = 131 [54%], nHH: n = 111 [46%]) were included. Men with absent puberty had significantly lower gonadotropin levels (P &lt; .001) and were more likely to have undetectable LH (P &lt; .001). Logistic regression showed partial puberty as a statistically significant predictor of pulsatile LH secretion (R2 = 0.71, P &lt; .001, OR: 10.8; 95% CI, 3.6-38.6). Serum LH of 2.10 IU/L had a 95% true positive rate for predicting LH pulsatility. Genetic analyses in 204 of 242 IHH men with ES data available revealed 36 of 204 (18%) men carried protein-truncating variants (PTVs) in 12 IHH genes. Men with absent puberty and apulsatile LH were enriched for oligogenic PTVs (P &lt; .001), with variants in ANOS1 being the predominant PTV in this genotype-phenotype association. Men with absent puberty were enriched for ANOS1 PTVs compared to partial puberty counterparts (P = .002). PTVs in other IHH genes imparted more variable reproductive phenotypic severity.

Conclusion
Partial puberty and LH greater than or equal to 2.10 IU/L are proxies for pulsatile LH secretion. ANOS1 PTVs confer severe reproductive phenotypes. Variable phenotypic severity in the face of severe genetic variants in other IHH genes point to significant neuroendocrine plasticity of the HPG axis in IHH men.
Biological and Therapeutic Implications of the Tumor Microenvironment in Pituitary Adenomas
Authors: Ilie Mirela-Diana , Vasiljevic Alexandre , Bertolino Philippe , Raverot Gérald 
Published: October 2022

AbstractPituitary adenomas (PAs) are neoplasms derived from the endocrine cells of the anterior pituitary gland. Most frequently, they are benign tumors, but may sometimes display an aggressive course, and in some cases metastasize. Their biology, including their wide range of behavior, is only partly understood. In terms of therapeutic targeting, most PAs are easily treated with available medical treatments, surgery, and sometimes radiotherapy. Nevertheless, gonadotroph adenomas lack medical therapeutic options, and treatment of aggressive PAs and pituitary carcinomas remains challenging. Here, we present an overview of the implications of the tumor microenvironment in PAs, reviewing its composition and function, as well as published cases that have been treated thus far using tumor microenvironment–targeting therapies. Additionally, we discuss emerging views, such as the concept of nonangiogenic tumors, and present perspectives regarding treatments that may represent future potential therapeutic options. Tumor-infiltrating lymphocytes, tumor-associated macrophages, folliculostellate cells, tumor-associated fibroblasts, angiogenesis, as well as the extracellular matrix and its remodeling, all have complex roles in the biology of PAs. They have been linked to hormone production/secretion, size, invasion, proliferation, progression/recurrence, and treatment response in PAs. From a therapeutic perspective, immune-checkpoint inhibitors and bevacizumab have already shown a degree of efficacy in aggressive PAs and pituitary carcinomas, and the use of numerous other tumor microenvironment-targeting therapies can be foreseen. In conclusion, similar to other cancers, understanding the tumor microenvironment improves our understanding of PA biology beyond genetics and epigenetics, and constitutes an important tool for developing future therapies.
Editorial
Authors: Coelho Arnaldo Fernandes Matos , Weersma Laodicéia Amorim 
Published: October 2022

É indiscutível que o ecossistema de inovação seja imprescindível para o desenvolvimento social, econômico e cultural de uma nação e, por conseguinte, para a melhora substancial da vida em sociedade. Constata-se, assim, a importância da ciência e da tecnologia para dar soluções inteligentes que considerem crescimento concomitante com maior igualdade social e preservação ambiental.