bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis
Authors: Jin Yujuan , Zhao Qiqi , Zhu Weikang , Feng Yan , Xiao Tian , Zhang Peng , Jiang Liyan , Hou Yingyong , Guo Chenchen , Huang Hsinyi , Chen Yabin , Tong Xinyuan , Cao Jiayu , Li Fei , Zhu Xueliang , Qin Jun , Gao Dong , Liu Xin-Yuan , Zhang Hua , Chen Luonan , Thomas Roman K , Wong Kwok-Kin , Zhang Lei , Wang Yong , Hu Liang , Ji Hongbin 
Published: December 2021

Abstract
Small-cell lung cancer (SCLC) is a recalcitrant cancer characterized by high metastasis. However, the exact cell type contributing to metastasis remains elusive. Using a Rb1L/L/Trp53L/L mouse model, we identify the NCAMhiCD44lo/– subpopulation as the SCLC metastasizing cell (SMC), which is progressively transitioned from the non-metastasizing NCAMloCD44hi cell (non-SMC). Integrative chromatin accessibility and gene expression profiling studies reveal the important role of the SWI/SNF complex, and knockout of its central component, Brg1, significantly inhibits such phenotypic transition and metastasis. Mechanistically, TAZ is silenced by the SWI/SNF complex during SCLC malignant progression, and its knockdown promotes SMC transition and metastasis. Importantly, ectopic TAZ expression reversely drives SMC-to-non-SMC transition and alleviates metastasis. Single-cell RNA-sequencing analyses identify SMC as the dominant subpopulation in human SCLC metastasis, and immunostaining data show a positive correlation between TAZ and patient prognosis. These data uncover high SCLC plasticity and identify TAZ as the key molecular switch in orchestrating SCLC phenotypic transition and metastasis.
Short-Term Safety of Booster Immunization With BNT162b2 mRNA COVID-19 Vaccine in Healthcare Workers
Authors: Paran Yael , Saiag Esther , Spitzer Avishay , Angel Yoel , Yakubovsky Michal , Padova Hagit , Ben-Ami Ronen , Goldinger Ilana , Gamzu Ronni , Sprecher Eli , Zeltser David , Henig Oryan 
Published: December 2021

Abstract
This study demonstrated a favorable short-term safety profile after a third dose of the BNT162b2 vaccine among healthcare workers (HCWs). There were more frequent local reactions and less systemic reactions compared to the second dose. The HCWs who reported reactions had higher prebooster titer of anti-S1 antibodies compared to those who reported no reactions.
Governance Networks, Bureaucracy, and Democracy
Authors: Morçöl Göktuğ , Shafi Saahir , Menon Aravind 
Published: December 2021

AbstractAre bureaucratic and network forms of organization compatible with democracy? Two observations made in the literature inspire this question: Liberal democracies around the world have been challenged by populist authoritarian movements and leaders, and multicentric forms of governance (i.e., governance networks) are utilized increasingly in public policymaking and service delivery in many of these democracies. Based on these observations, we propose that a conceptual investigation of the possible links between three ideal types of democracy (i.e., liberal, deliberative/discursive, and practice-based democracy) and two ideal types of social organization (bureaucracy and governance networks) can help us to better understand the challenges in public policy making and administration in the early 21st century. In doing so, we adopt Max Weber’s conceptual analytical method of using ideal typical abstractions and understanding their historical contexts. With our conceptual analysis, we demonstrate that governance networks may be problematic for liberal and deliberative forms of democracy and are most compatible with practice-based democracy. We propose that a configurational approach should be used in conceptualizing the relations between the ideal types of democracy and social organization.
Chiral waves in structured elastic systems: dynamics of a meta-waveguide
Authors: Jones I S , Movchan N V , Movchan A B 
Published: December 2021

Summary
The notion of meta-surfaces is well established for waves interacting with arrays of periodic resonators. Here, an infinite elastic rod, attached to a system of gyroscopic spinners, is considered. This forms a waveguide with unusual dispersion properties and will be referred to as a chiral meta-waveguide. A class of transient and time-harmonic formulations describing waves in elastic chiral meta-waveguides is addressed. Consideration of a chiral elastic chain leads to the governing equations of the homogenised continuous system. Both analytical and numerical solutions are presented. Features observed for chiral waveforms show resemblance with formulations of quantum physics rather than linear elasticity. For an elementary example related to an elastic chiral rod, with the absence of pre-tension, it is noted that the longitudinal velocity satisfies the Klein–Gordon equation. For full vector problems, corresponding to an elastic chiral rod with pre-tension, time-harmonic Green’s matrix functions are derived for the case of large values of the gyricity parameter. This case is especially interesting because of the presence of both exponentially localised and oscillatory terms in the representation of Green’s matrix components.
INVESTIGATION OF ENVIRONMENTAL RADIOACTIVITY AT A DECOMMISSIONED URANIUM MINE IN SOUTHERN CHINA
Authors: Wu Hexi , Di Runjie , Liu Yibao , Liu Yujuan , Xiong Chao , Shi Yuke 
Published: December 2021

Abstract
An environmental radioactivity survey was performed on a uranium mine that has been decommissioned for &gt;10 y. According to the characteristics of this uranium mine, the relevant parameters, such as the surface-absorbed dose rate in air, the radon and radon progeny concentrations in the air, the radon exhalation rate from the soil surface and the concentrations of natural radionuclides in soil and surface water, were measured. The results show that the maximum annual effective doses of residents and employees in the uranium mine caused by radon and radon progenies inhalation were 1.48 and 1.74 mSv, respectively, and the maximum annual effective doses of residents and employees caused by gamma-ray external radiation were 1.16 and 1.32 mSv, respectively.
Contextual influences on implementation of online behavioral obesity treatment in primary care: formative evaluation guided by the consolidated framework for implementation research
Authors: Espel-Huynh Hallie M , Goldstein Carly M , Stephens Michael L , Finnegan Olivia L , Elwy A Rani , Wing Rena R , Thomas J Graham 
Published: December 2021

Abstract
Online behavioral obesity treatment is a promising first-line approach to weight management in primary care. However, little is known about contextual influences on implementation. Understand qualitative contextual factors that affect the implementation process, as experienced by key primary care stakeholders implementing the program. Online behavioral obesity treatment was implemented across a 60-clinic primary care practice network. Patients were enrolled by nurse care managers (NCMs; N = 14), each serving 2–5 practices. NCMs were randomized to one of two implementation conditions—“Basic” (standard implementation) or “Enhanced” (i.e., with added patient tracking features and more implementation strategies employed). NCMs completed qualitative interviews guided by the Consolidated Framework for Implementation Research (CFIR). Interviews were transcribed and analyzed via directed content analysis. Emergent categories were summarized by implementation condition and assigned a valence according to positive/negative influence. Individuals in the Enhanced condition viewed two aspects of the intervention as more positively influencing than Basic NCMs: Design Quality & Packaging (i.e., online program aesthetics), and Cost (i.e., no-cost program, clinician time savings). In both conditions, strongly facilitating factors included: Compatibility between intervention and clinical context; Intervention Source (from a trusted local university); and Evidence Strength & Quality supporting effectiveness. Findings highlight the importance of considering stakeholders’ perspectives on the most valued types of evidence when introducing a new intervention, ensuring the program aligns with organizational priorities, and considering how training resources and feedback on patient progress can improve implementation success for online behavioral obesity treatment in primary care.
Sequencing SARS-CoV-2 genomes from saliva
Authors: Alpert Tara , Vogels Chantal B F , Breban Mallery I , Petrone Mary E , Wyllie Anne L , Grubaugh Nathan D , Fauver Joseph R 
Published: December 2021

Abstract
Genomic sequencing is crucial to understanding the epidemiology and evolution of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Often, genomic studies rely on remnant diagnostic material, typically nasopharyngeal (NP) swabs, as input into whole-genome SARS-CoV-2 next-generation sequencing pipelines. Saliva has proven to be a safe and stable specimen for the detection of SARS-CoV-2 RNA via traditional diagnostic assays; however, saliva is not commonly used for SARS-CoV-2 sequencing. Using the ARTIC Network amplicon-generation approach with sequencing on the Oxford Nanopore MinION, we demonstrate that sequencing SARS-CoV-2 from saliva produces genomes comparable to those from NP swabs, and that RNA extraction is necessary to generate complete genomes from saliva. In this study, we show that saliva is a useful specimen type for genomic studies of SARS-CoV-2.
Cinematic Simulation
Authors: Sheridan Rhonda , Williams Jacque 
Published: December 2021

Abstract
With fewer clinical placements for psychiatric mental health (PMH) education and a steady increase in student enrollment, faculty search for creative ways to replace patient care experiences for students to achieve high-quality learning outcomes. Simulation is an acceptable practice for patient care experiences, but research related to PMH simulation is limited. This article describes the development, implementation, and evaluation of cinematic simulation, an innovative PMH clinical experience where students engage in watching films while performing the various aspects of the nursing role.
Cutaneous Plasmacytosis and Idiopathic Multicentric Castleman Disease: A Spectrum of Disease?
Authors: Drissi Madeeha , Dunlap Rachel , Clayton Lara , Raess Philipp W. , Mengden Koon Stephanie , White Kevin 
Published: December 2021

Abstract:
Cutaneous/systemic plasmacytosis (C/SP) is a plasma cell disorder characterized by reddish–brown patches, lymphadenopathy, and hypergammaglobulinemia. The degree to which C/SP overlaps with other plasma cell proliferative disorders and neoplasms is incompletely understood. We present the case of a patient with a several-year history of cutaneous plasmacytosis and evidence of systemic involvement with concurrent idiopathic multicentric Castleman disease (iMCD) involving a lymph node. There have been only a few reports of systemic iMCD preceded by a long, asymptomatic phase of cutaneous manifestations. We discuss the relationship between C/SP and iMCD and elaborate on the pathophysiological overlap of these 2 conditions and potential similarities in their pathogenesis. We suggest that the 2 diseases may represent the same entity presenting on a spectrum, with individuals diagnosed with C/SP at risk for progression to iMCD.
Melanocytic Panfolliculoma: A Case Report of a Rare Benign Follicular Tumor
Authors: Preston Allie , West Cameron , McCollough Martha , Hosler Gregory A. 
Published: December 2021

Abstract:
Panfolliculomas (PF) are rare, benign, follicular tumors that differentiate toward multiple components of the hair follicle, and several variants have been described. We present a case of a rare pigmented PF presenting on actinically damaged skin in an 83-year-old man, which was clinically concerning for malignancy. This tumor arose near an area of atypical squamous proliferation and has evidence of infundibular, outer root sheath, and matrical differentiation and foci of heavy melanin pigmentation and increased melanocytes. We propose the novel designation of “melanocytic PF,” akin to melanocytic matricoma but with panfollicular differentiation.
Prolonged viral positivity induced recurrent coronavirus disease 2019 (COVID-19) pneumonia in patients receiving anti-CD20 monoclonal antibody treatment
Authors: Deveci Burak , Saba Rabin 
Published: December 2021

Abstract

Introduction:
The outbreak of novel coronavirus (severe acute respiratory syndrome coronavirus 2), which causes the coronavirus disease 2019 (COVID-19), is the most important current health problem. The number of patients is increasing worldwide. Pneumonia is the most life-threatening complication of the disease. Prolonged viral shedding in hematological patients with COVID-19 has been demonstrated; however, data on COVID-19 patients receiving anti-CD20 monoclonal antibody therapy are limited. Accordingly, focusing on humoral immunity, herein, we present 4 COVID-19 patients who were on anti-CD20 monoclonal antibody treatment and had prolonged pneumonia.

Patient concerns:
Two of 4 patients were on rituximab and the other 2 were on obinutuzumab therapy.

Diagnosis:
The polymerase chain reaction test results for severe acute respiratory syndrome coronavirus 2 were positive for all 4 patients and their COVID pneumonia lasted for >50 days.

Interventions:
Although all patients were treated with an adequate amount of convalescent plasma, prolonged polymerase chain reaction positivity and prolonged pneumonia were possibly due to the lack of ability of the immune system to initiate its antibody response.

Outcomes:
Despite the administration of standard therapies, recurrent pneumonia observed in the present case series of non-neutropenic patients, in whom primary malignancies were under control.

Conclusions:
It is suggested that further investigations should be performed to understand the underlying pathophysiology.
Comparison of Sodium Bicarbonate and Lactated Ringers Hydration for High-dose Methotrexate Chemotherapy in Children
Authors: Kendrick Jennifer , Jacques Lisa , Baadjes Björn , Carr Roxane 
Published: December 2021

Background:
High-dose methotrexate is part of the treatment of pediatric cancers. To reduce the risk of toxicity, supportive measures, including hydration and alkalinization, are recommended. At our institution, we switched from intravenous sodium bicarbonate to Lactated Ringers during a worldwide shortage.

Procedure:
This was a retrospective cohort of children who received high-dose methotrexate from January 1, 2016 to August 31, 2018. The primary outcome was the prevalence of delayed methotrexate clearance. Secondary outcomes were proportion of cycles with delayed methotrexate clearance, time to methotrexate clearance, adverse events, risk factors for delayed clearance, and association between hydration type and delayed clearance.

Results:
Eighty-two patients, with a total of 325 methotrexate cycles, were included. Forty-four patients received sodium bicarbonate, 31 received Lactated Ringers, and 7 received both. There was no difference in the prevalence of delayed methotrexate clearance between those who received sodium bicarbonate and Lactated Ringers (64% vs. 68%). The proportion of cycles with delayed methotrexate clearance, time to methotrexate clearance, and adverse events were similar between groups. Cancer type, methotrexate dose, and vomiting were associated with delayed clearance.

Conclusions:
Our study suggests that Lactated Ringers may be used in place of sodium bicarbonate for intravenous hydration during high-dose methotrexate.
Adaptation of Metabolomics and Microbiomic Research Protocols During the COVID-19 Pandemic
Authors: Butts Brittany , Alford Taqiyya , Brewster Glenna , Carlson Nicole , Coleman Ebony , Davis Erica , Ferranti Erin , Kimble Laura P. , Narapareddy Laren , Wells Jessica , Yang Irene 
Published: December 2021

Background
When the COVID-19 pandemic hit in 2020, researchers in the P30 Center for the Study of Symptom Science, Metabolomics, and Multiple Chronic Conditions at Emory University’s Nell Hodgson Woodruff School of Nursing faced major challenges in recruitment and data collection because of limited access to the clinic and community facilities and the risk of COVID-19 exposure associated with in-person study contact.

Objectives
The purpose of this article is to (a) describe how a cadre of pilot/supplement principal investigators adapted their studies to allow for safe and trustworthy data collection during the COVID-19 pandemic (March 2020 through date of publication) and (b) discuss steps that facilitated the technical aspects of remote data collection, especially involving biological specimens.

Results
Four pilot studies and two administrative supplements within the center—all at different stages of execution—adopted various alternative remote recruitment, enrollment, and data and specimen collection approaches to continue their research endeavors in a way that maximized the safety of both the research participants and the research teams.

Discussion
The article concludes with a discussion on the importance of a participant-centered approach when using remote methods, actions, or steps initiated to facilitate the technical aspects of remote data collection and reflections on the continued use of remote research strategies beyond the COVID-19 pandemic.
Effectiveness of Ultrasound-Guided Versus Anatomic Landmark–Guided Corticosteroid Injection on Pain, Physical Function, and Safety in Patients With Subacromial Impingement Syndrome
Authors: Deng Xiaoyan , Zhu Siyi , Li Daishun , Luo Yi , Zhang Xin , Tan Yanling , Li Juan , He Xia 
Published: December 2021

Objective
The aim of the study was to compare the efficacy and safety of ultrasound-guided versus anatomic landmark–guided corticosteroid injection for the treatment of subacromial impingement syndrome.

Design
PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, Scopus, ClinicalTrials.gov, CBM, CNKI, and Wanfang databases were searched from inception to August 15, 2021, for randomized controlled trials comparing ultrasound-guided versus anatomic landmark–guided injections of corticosteroids for the treatment of subacromial impingement syndrome.

Results
Twelve randomized controlled trials with 891 patients were included in this study; 454 patients received ultrasound-guided injections and 437 received anatomic landmark–guided injections. Pooled results showed that ultrasound-guided injection was more beneficial for pain relief (10 trials; mean difference = −0.58; 95% confidence interval = −1.05 to −0.10; P = 0.017) and functional improvement (11 trials; standard mean difference = −0.84; 95% confidence interval = −1.41 to −0.27; P = 0.004). There was no significant difference in shoulder range of motion. In the subgroup analysis, there was a significant difference in pain relief and functional improvement at 6–8 wks and with methylprednisolone.

Conclusions
Ultrasound-guided injection of corticosteroids is potentially superior to anatomic landmark–guided injection in improving the clinical symptoms of subacromial impingement syndrome; however, these findings should be interpreted with some caution as the quality of evidence was rated as moderate to very low.
Impacts of HIV-1 Subtype Diversity on Long-Term Clinical Outcomes in Antiretroviral Therapy in Guangxi, China
Authors: Jiang He , Lan Guanghua , Zhu Qiuying , Feng Yi , Liang Shujia , Li Jianjun , Zhou Xinjuan , Lin Mei , Shao Yiming 
Published: December 2021

Background:
Comprehensively estimating the impacts of HIV-1 subtype diversity on long-term clinical outcomes during antiretroviral therapy (ART) can help inform program recommendations.

Methods:
The HIV-1 sequence data and clinical records of 5950 patients from all 14 prefectures in Guangxi, China, during 2008–2020 were included. Evolutional trends of CD4+ T-lymphocyte count and viral load were explored, and the effects of HIV-1 subtypes on clinical outcomes were estimated by the Cox proportional hazards model. The polymorphisms involved in drug resistance mutation were analyzed.

Results:
Compared with patients with CRF07_BC, patients with CRF01_AE and CRF08_BC showed poor immunologic and virologic responses to antiretroviral therapy. Although the median expected time from ART initiation to virologic suppression for all patients was approximately 12 months, patients with CRF01_AE and CRF08_BC had a long time to achieve immune recovery and a short time to occur immunologic failure, compared with patients with CRF07_BC. Adjusted analysis showed that both CRF01_AE and CRF08_BC were the negative factors in immune recovery and long-term mortality. In addition, CRF08_BC was a negative factor in virologic suppression and a risk factor of virologic failure. This poor virologic response might result from the high prevalence of drug resistance mutation in CRF08_BC.

Conclusions:
Compared with patients with CRF07_BC, patients with CRF01_AE could benefit more from immediate ART, and patients with CRF08_BC are more suitable for PI-based regimens. These data emphasize the importance of routine HIV-1 genotyping before ART, immediate ART, and personalized ART regimens to improve the prognosis for patients undergoing ART.
Review of Our Experience Using Modified Staple Line Suturing Technique in Laparoscopic Sleeve Gastrectomy
Authors: Şen Ozan , Türkçapar Ahmet G. 
Published: December 2021

Background:
Laparoscopic sleeve gastrectomy (LSG) has become the most common bariatric surgical method in recent years. Although LSG provides good outcomes, serious complications such as leakage, bleeding, and stenosis may develop postoperatively. Numerous staple line reinforcement methods have been used to reduce complications. Whether each one of these practices is effective remains controversial.

Aim:
Our study aims to assess outcomes and safety of modified (purse-string+oversewing) staple line suturing technique for patients who underwent LSG.

Materials and Methods:
A total of 505 patients who underwent LSG with modified staple line suturing technique between March 2018 and February 2021 were included in this retrospective study. Age, sex, body mass index, operation time, perioperative and postoperative 30-day complications were recorded in all patients.

Results:
Of 505 patients (59.6% female) with a mean age of 37.6 years (minimum to maximum: 12 to 68 y) and median body mass index of 40.2 kg/m2 (minimum to maximum: 32 to 75 kg/m2) underwent LSG. LSG was performed as revision surgery in 17 (3.4%) patients. Five (1%) patients also underwent concomitant cholecystectomy. The mean operation time was 92 minutes (75 to 110 min) in our primary LSG cases. Operative complications included minor hepatic injury in 8 (1.6%) and anesthesia awareness in 3 (0.6%) patients. Postoperative complications included bleeding which occurred in 2 (0.4%) patients, portomesenteric vein thrombosis in 1 (0.2%), and minor wound infection in 3 (0.6%) patients. There was no leak, no stenosis, and no mortality.

Conclusion:
Sleeve gastrectomy with modified staple line suturing technique is an effective method and could be safely applied with low morbidity.