bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical Determination of Longitudinal Forces on the Vessels During Filling of the Navigation Lock
Authors: Kašpar T 
Published: October 2022

Abstract
The basic parameter for the calculation of the lock filling time is the determination of the forces on the vessels during the filling of the navigation lock. The time required to fill the lock determines the method of filling the lock. The forces on vessels during filling (emptying) directly determine the capacity of the waterway. In the first phase of the lock design, the forces on the vessels during locking are calculated analytically. Most approaches to calculate the forces on vessels are concerned only with finding the maximum value of the forces on vessels. This research deals with the analytical determination of the maximum forces on vessels during the lock filling period. Data from the physical model and the 1D model are used to calculate the maximum forces on the vessels. This simple method can be used to design a new lock. This simple method can be used to design a new lock and to increase the capacity of existing historic locks on the Elbe-Vltava Waterway (Czech Republic) without any structural modifications.
Use of Building Information Modelling (BIM) in planning and managing the life cycle of buildings
Authors: Smetanková J , Mésároš P , Krajníková K , Biolek V 
Published: October 2022

Abstract
Many studies and research point to a growing trend in industrial digitization. New materials, technologies and advanced automation tools are increasingly being promoted in the construction industry. With the increasing degree of digitization, various ways and methods of planning, management and control across different construction processes are also increasing. BIM is a unified information system that enables the sharing of documentation, supports communication, streamlines individual processes, helps eliminate errors and increases quality. Based on this fact, the paper analyses the current state of use of Building Information Modelling in planning and managing the life cycle of buildings in Slovakia and the Czech Republic. The current state of knowledge and use of BIM, defining the advantages and possible barriers to its use, examining the scope and potential of BIM implementation within the building life cycle and defining tools and applications used in time and financial planning of construction production were analysed. The paper also briefly examines how the implementation of BIM can affect selected key tasks of the preparation and valuation professions.
Overview of meteorological and hydrological conditions in the Hornád river basin
Authors: Nagy P , Garaj M , Hlinková M 
Published: October 2022

AbstractThe assessment of deficit and surplus volumes is important for assessing the effects of climate change on water management. Climate change needs to be taken into account in water management. At a time of climate change, there is a frequent occurrence of such periods, but also torrential rains, it is necessary to assess the quantity and quality of surface waters. Building structures must be designed in such a way that, during the period of torrential rains, they retain water from the surface runoff and prevent any damage that could arise from the original; sufficient water and dry season must be ensured during the period. Water shortages can also be caused by increased water consumption. The assessment of the volume of water in the Hornád river basin has shown that it is possible to mitigate climate change.
A new framework for drug–disease association prediction combing light-gated message passing neural network and gated fusion mechanism
Authors: Liu Bao-Min , Gao Ying-Lian , Zhang Dai-Jun , Zhou Feng , Wang Juan , Zheng Chun-Hou , Liu Jin-Xing 
Published: October 2022

AbstractWith the development of research on the complex aetiology of many diseases, computational drug repositioning methodology has proven to be a shortcut to costly and inefficient traditional methods. Therefore, developing more promising computational methods is indispensable for finding new candidate diseases to treat with existing drugs. In this paper, a model integrating a new variant of message passing neural network and a novel-gated fusion mechanism called GLGMPNN is proposed for drug–disease association prediction. First, a light-gated message passing neural network (LGMPNN), including message passing, aggregation and updating, is proposed to separately extract multiple pieces of information from the similarity networks and the association network. Then, a gated fusion mechanism consisting of a forget gate and an output gate is applied to integrate the multiple pieces of information to extent. The forget gate calculated by the multiple embeddings is built to integrate the association information into the similarity information. Furthermore, the final node representations are controlled by the output gate, which fuses the topology information of the networks and the initial similarity information. Finally, a bilinear decoder is adopted to reconstruct an adjacency matrix for drug–disease associations. Evaluated by 10-fold cross-validations, GLGMPNN achieves excellent performance compared with the current models. The following studies show that our model can effectively discover novel drug–disease associations.
Multi-model predictive analysis of RNA solvent accessibility based on modified residual attention mechanism
Authors: Huang Yuyao , Luo Jiesi , Jing Runyu , Li Menglong 
Published: October 2022

Abstract
Predicting RNA solvent accessibility using only primary sequence data can be regarded as sequence-based prediction work. Currently, the established studies for sequence-based RNA solvent accessibility prediction are limited due to the available number of datasets and black box prediction. To improve these issues, we first expanded the available RNA structures and then developed a sequence-based model using modified attention layers with different receptive fields to conform to the stem–loop structure of RNA chains. We measured the improvement with an extended dataset and further explored the model’s interpretability by analysing the model structures, attention values and hyperparameters. Finally, we found that the developed model regarded the pieces of a sequence as templates during the training process. This work will be helpful for researchers who would like to build RNA attribute prediction models using deep learning in the future.
Photoperiod affects female life history traits in temperate populations of Aedes aegypti from South America
Authors: Campos Raúl E , Di Battista Cristian M , De Majo María Sol , Montini Pedro , Fischer Sylvia 
Published: October 2022

Abstract
In many insects, short photoperiods induce females to lay diapausing eggs, which are associated with a reduction in female fecundity, and/or with an increase in their growth rate, allowing for a larger size at adulthood. The effects of short photoperiods may also differ among populations, depending on the different selection pressures imposed by the winter conditions. Thus, this study aimed to experimentally assess the effects of short photoperiods on Aedes aegypti, an invasive mosquito species that also vectors several viral diseases. We compared life history parameters of the females reared from the first larval instar under contrasting photoperiods, in two populations from the temperate region of Argentina, one with a milder winter (BA) and the other with a harsher winter (SB). The results showed a significant increase in the time to oviposition, a trend to a larger size of females (significant only for SB) and higher inhibition of egg hatching (more pronounced in SB), in response to short photoperiods. No differences in fecundity were detected among treatments. The different reaction norms of the populations in female body size and egg hatching response suggest an adaptation to local conditions, which might favour a further expansion of A. aegypti towards colder climates.
Successful laparoscopic pheochromocytoma resection in an adult patient with Fontan physiology: a case report
Authors: Nohara-Shitama Yume , Takahashi Jinya , Homma Takehiro , Igawa Tsukasa , Fukumoto Yoshihiro 
Published: October 2022

Abstract

Background
Pheochromocytoma is a rare tumour producing catecholamines and has been more frequently reported than expected in patients with a Fontan physiology.

Case summary
The patient was a 39-year-old woman born with a univentricular atrioventricular connection and pulmonary valve stenosis. A Fontan operation was performed when she was 22 years old. At the age of 38, she was diagnosed with pheochromocytoma. The most serious problem was the increased occurrence of supraventricular arrhythmias, which easily caused heart failure. We decided to perform a laparoscopic resection. Postoperative recovery was good. There were no findings of malignancy and all postoperative catecholamine levels normalized. She was discharged home on the 14th day after the surgery, walking unaided.

Discussion
Diagnosis and treatment by tumour resection in the early phase are crucial in patients who undergo the Fontan procedure. However, patients after Fontan surgery have a very low cardiac reserve. Thus, the decision to perform a surgical treatment is a very difficult one to take. In this case, fenestration had been naturally closed. As fenestration provides a consistent source of systemic ventricular preload, we performed transcatheter fenestration dilatation to improve heart failure management before surgical pheochromocytoma removal. Although laparoscopic surgery is generally considered to be less invasive, pneumoperitoneum may interfere with venous return in Fontan physiology patients. There is also a risk of thrombosis via fenestration. Here, we reported the case of a successful laparoscopic pheochromocytoma resection in an adult Fontan patient.
Case report of a ventricular fibrillation storm with a cardiac conduction disorder and HCN4 variant 18 years after ablation of atrial flutter
Authors: Nakamura Toshihiro , Fukuzawa Koji , Aiba Takeshi , Ohno Seiko 
Published: October 2022

Abstract

Background
Genetic abnormalities causing various arrhythmias including atrial arrhythmias, specialized cardiac conduction disorders, and malignant ventricular arrhythmias have been reported. However, it is sometimes difficult to diagnose and treat patients with various arrhythmias.

Case summary
A 49-year-old woman who underwent ablation of typical atrial flutter (AFL) at 31 years of age visited the emergency room due to a cardiopulmonary arrest. Her 12-lead electrocardiogram during sinus rhythm after resuscitation exhibited first-degree atrioventricular block with right bundle branch block and right axis deviation. No structural heart disease was evident on standard imaging screening. An implantation of a single-chamber implantable cardioverter defibrillator (ICD) was indicated. After the ICD implantation, she then experienced multiple ventricular fibrillation (VF) episodes. Radiofrequency catheter ablation of triggered ventricular premature contractions (VPCs) was performed but failed because the clinical VPCs could not be induced during the session. Although no pathogenic variants associated with Brugada syndrome or long-QT syndrome were found, a rare HCN4 variant, c.1209+2_1209+3insGAGT (rs786205418), was identified in a gene panel analysis. Because high-frequency clinical pacing was effective for suppressing the VF, the single-chamber ICD was upgraded to a dual-chamber ICD. Thereafter, high-rate pacing successfully prevented any further ventricular arrhythmias during the follow up.

Discussion
A clinical course with prominent wide QRS complexes and AFL in one’s early 30s followed by sudden onset of a VF storm about 20 years later is extremely rare. Her clinical phenotype expression was possibly associated with a rare HCN4 variant; however, further study is needed to confirm whether this variant was pathological or not.
Æthelflaed and Other Rulers in English Histories, c.900–1150
Authors: Winkler Emily A 
Published: October 2022

Abstract
This article explains why Æthelflaed, ruler of Mercia, mattered to writers of history in twelfth-century England. It argues that these writers evaluated and compared rulers based not on sex or bloodline, but on the quality of a ruler’s achievements relative to the set and scale of challenges the ruler faced. They thought Æthelflaed remarkable because her triumphs for Mercia distinguished her from other rulers. The article shows that a new understanding of attitudes in twelfth-century England towards rulers, past and present, is required. It accounts for the absence of gendered comments about rulers, as well as the presence of non-binary concepts of gender, in medieval writing. It also challenges the enduring idea that Latin writers imposed a shared, Wessex-dominated national vision on the English past. They asserted Mercia’s independence under Æthelflaed’s sole rule, which shows that English regional interests persisted in the historical imagination long after the Norman Conquest.
Why making promotion after a burnout is like boiling the ocean
Authors: Sterkens Philippe , Baert Stijn , Rooman Claudia , Derous Eva 
Published: October 2022

Abstract
Recent studies have explored hiring discrimination as an obstacle to former burnout patients. A substantial share of the burned-out working population, however, returns to the same employer, where they face an even more severe aftermath of burnout syndrome: promotion discrimination. To our knowledge, we are the first to directly address this issue. More specifically, we conducted a vignette experiment with 406 managers, testing the potential of the main burnout stigma theoretically described in the literature as potential mediators of promotion discrimination. Estimates reveal that compared to employees without an employment interruption, former burnout patients are assigned a 34 per cent lower promotion propensity score. Moreover, negative perceptions are associated with a history of job burnout. Four of these perceptions, namely lower leadership capacities, stress tolerance, abilities to take on an exemplary role, and chances of finding another job explain almost half the burnout effect on promotion propensities.
Differential effect of high-frequency electroporation on myocardium vs. non-myocardial tissues
Authors: Moshkovits Yonatan , Grynberg Dvora , Heller Eyal , Maizels Leonid , Maor Elad 
Published: October 2022

AbstractAimsPulsed-field ablation (PFA) is an emerging non-thermal ablation method based on the biophysical phenomenon of electroporation. Data on PFA cardiac selectivity nature and tissue-specific thresholds are lacking. We aim to compare the in vivo differential effect of high-frequency irreversible electroporation (HF-IRE) protocols on various tissues.Methods and resultsTwenty-three Sprague-Dawle rodents were allocated into three different protocols of 300, 600, and 900 V, respectively, while delivering twenty 100 µs bursts of a 150 kHz biphasic square wave to five tissues; cardiac muscle, skeletal muscle, liver, carotid artery and sciatic nerve. Lesions were evaluated quantitatively by histologic analysis and by morphometric evaluation. There were eight, seven and eight animals in the 300, 600, and 900 V protocols, respectively. High-frequency electroporation protocols showed a graded effect on myocardial tissue with larger lesions in the 900 V protocol compared with the other two protocols as demonstrated by width (P = 0.02), length (P = 0.01) and fibrosis ratio (P = 0.001). This effect was not observed for other tissues with attenuated degree of damage. No damage to the carotid artery was observed in all protocols. Partial damage to the sciatic nerve was observed in only two samples (25%) in the 600 V group and in one sample (14.3%) in the 900 V group.ConclusionElectroporation effect is tissue-specific such that myocardium is more prone to electroporation damage compared with neural and vascular tissues. Our results suggest no neural or vascular damage with using a low-amplitude HF-IRE protocol. Further investigation is warranted to better identify other tissue-specific thresholds.
Rapid fabrication of large-area and uniform surface-enhanced Raman spectroscopy substrate of Au nano-hemisphere array and its application in the detection of Malachite Green in tilapia
Authors: Zhang Qin , Han Jiaojiao , Chen Yanhong , Jia Zhiqing , Pan Xiaohui , Rani Karuppasamy Kohila , Zhou Jianzhang , Jiao Tianhui , Chen Qingmin , Wu Deyin 
Published: October 2022

Abstract
Although surface-enhanced Raman spectroscopy (SERS) substrates have achieved high sensitivity, it is still difficult to apply these SERS protocols to the on-site detection of real samples due to the SERS substrate being fabrication-complexed, unstable, reproducible, or unable to be applied in batch production. Here, a large-scale ordered two-dimensional array of Au nano-hemispheres was developed through electron beam vaporization of Au onto the easy-available commercialized anodic aluminum oxide (AAO) template with two-layer nanostructures of different diameters. The uniform Au nano-hemisphere is reliable for SERS detection of malachite green (MG) due to the relative standard deviation (RSD) of the SERS intensities at different locations less than 10%. With the optimized excitation wavelength, solvent effect and pH environment, the linear range of MG detection spans from 10–10 to 10–6 mol/L with a limit of detection (LOD) of 4×10–10 mol/L. The enhancement factor can reach 1.2×106. After extraction with acetonitrile and dichloromethane, MG in the spiked tilapia was detected with satisfactory recovery. The results indicate that the Au nano-hemisphere array can be expected to greatly facilitate SERS practical applications in detecting harmful food additives and chemicals due to the advantages of chemical inertness, physical robustness, simple fabrication, controllability, large-area uniformity, and large-batch production.
Evolution and codon usage bias of mitochondrial and nuclear genomes in Aspergillus section Flavi
Authors: Hugaboom Miya , Hatmaker Elizabeth Anne , LaBella Abigail L , Rokas Antonis 
Published: October 2022

Abstract
The fungal genus Aspergillus contains a diversity of species divided into taxonomic sections of closely related species. Section Flavi contains 33 species, many of industrial, agricultural, or medical relevance. Here, we analyze the mitochondrial genomes (mitogenomes) of 20 Flavi species—including 18 newly assembled mitogenomes—and compare their evolutionary history and codon usage bias patterns to their nuclear counterparts. Codon usage bias refers to variable frequencies of synonymous codons in coding DNA and is shaped by a balance of neutral processes and natural selection. All mitogenomes were circular DNA molecules with highly conserved gene content and order. As expected, genomic content, including GC content, and genome size differed greatly between mitochondrial and nuclear genomes. Phylogenetic analysis based on 14 concatenated mitochondrial genes predicted evolutionary relationships largely consistent with those predicted by a phylogeny constructed from 2,422 nuclear genes. Comparing similarities in interspecies patterns of codon usage bias between mitochondrial and nuclear genomes showed that species grouped differently by patterns of codon usage bias depending on whether analyses were performed using mitochondrial or nuclear relative synonymous usage values. We found that patterns of codon usage bias at gene level are more similar between mitogenomes of different species than the mitogenome and nuclear genome of the same species. Finally, we inferred that, although most genes—both nuclear and mitochondrial—deviated from the neutral expectation for codon usage, mitogenomes were not under translational selection while nuclear genomes were under moderate translational selection. These results contribute to the study of mitochondrial genome evolution in filamentous fungi.
A dataset of ant colonies’ motion trajectories in indoor and outdoor scenes to study clustering behavior
Authors: Wu Meihong , Cao Xiaoyan , Yang Ming , Cao Xiaoyu , Guo Shihui 
Published: October 2022

Abstract

Background
The motion and interaction of social insects (such as ants) have been studied by many researchers to understand clustering mechanisms. Most studies in the field of ant behavior have focused only on indoor environments (a laboratory setup), while outdoor environments (natural environments) are still underexplored.

Findings
In this article, we collect 10 videos of 3 species of ant colonies from different scenes, including 5 indoor and 5 outdoor scenes. We develop an image sequence marking software named VisualMarkData, which enables us to provide annotations of the ants in the videos. (i) It offers comprehensive annotations of states at the individual-target and colony-target levels. (ii) It provides a simple matrix format to represent multiple targets and multiple groups of annotations (along with their IDs and behavior labels). (iii) During the annotation process, we propose a simple and effective visualization that takes the annotation information of the previous frame as a reference, and then a user can simply click on the center point of each target to complete the annotation task. (iv) We develop a user-friendly window-based GUI to minimize labor and maximize annotation quality. In all 5,354 frames, the location information and the identification number of each ant are recorded for a total of 712 ants and 114,112 annotations. Moreover, we provide visual analysis tools to assess and validate the technical quality and reproducibility of our data.

Conclusions
We provide a large-scale ant dataset with the accompanying annotation software. It is hoped that our work will contribute to a deeper exploration of the behavior of ant colonies.
Solitary Rectal Ulcer Syndrome Coexisting with Colitis Cystica Profunda—Is Mucosal Resection Radical or Not?
Authors: Zhang Yajie , Tian Feng , Li Hui 
Published: October 2022

Lay Summary
We highlight the key diagnostic features of solitary rectal ulcer syndrome coexisting with colitis cysticaprofunda in order to increase awareness of the postoperative recurrence of the diseases.
Software Application Profile: ShinyDataSHIELD—an R Shiny application to perform federated non-disclosive data analysis in multicohort studies
Authors: Escribà-Montagut Xavier , Marcon Yannick , Avraam Demetris , Banerjee Soumya , Bishop Tom R P , Burton Paul , González Juan R 
Published: October 2022

Abstract

Motivation
DataSHIELD is an open-source software infrastructure enabling the analysis of data distributed across multiple databases (federated data) without leaking individuals’ information (non-disclosive). It has applications in many scientific domains, ranging from biosciences to social sciences and including high-throughput genomic studies. R is the language used to interact with (and build) DataSHIELD. This creates difficulties for researchers who do not have experience writing R code or lack the time to learn how to use the DataSHIELD functions. To help new researchers use the DataSHIELD infrastructure and to improve the user-friendliness for experienced researchers, we present ShinyDataSHIELD.

Implementation
ShinyDataSHIELD is a web application with an R backend that serves as a graphical user interface (GUI) to the DataSHIELD infrastructure.

General features
The version of the application presented here includes modules to perform: (i) exploratory analysis through descriptive summary statistics and graphical representations (scatter plots, histograms, heatmaps and boxplots); (ii) statistical modelling (generalized linear fixed and mixed-effects models, survival analysis through Cox regression); (iii) genome-wide association studies (GWAS); and (iv) omic analysis (transcriptomics, epigenomics and multi-omic integration).

Availability
ShinyDataSHIELD is publicly hosted online [https://datashield-demo.obiba.org/], the source code and user guide are deposited on Zenodo DOI 10.5281/zenodo.6500323, freely available to non-commercial users under ‘Commons Clause’ License Condition v1.0. Docker images are also available [https://hub.docker.com/r/brgelab/shiny-data-shield].