bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant capacity as a novel biomarker of delirium after cardiac surgery
Authors: Kaźmierski J. , Pawlak A. , Miler P. , Jerczyńska H. , Woźniak J. , Frankowska E. , Woźniak K. , Brzezińska A. , Wilczyński M. 
Published: February 2022

IntroductionCoronary-artery bypass graft (CABG) surgery is known to improve cardiac function and decrease mortality, albeit, this method of treatment is associated with a high risk of postoperative delirium. The pathophysiology of delirium after cardiac surgery is largely unknown.ObjectivesTo investigate whether oxidative stress reflected by decreased preoperative and postoperative plasma antioxidant capacity (AC) is independently associated with delirium after cardiac surgery. Furthermore, to assess whether the association between AC and the level of soluble receptor for advanced glycation end-products (sRAGE) exists.MethodsThe patients were examined 1 day preoperatively with the Mini International Neuropsychiatric Interview and MMSE test to screen for depression, anxiety disorders, and for cognitive impairment, respectively. Blood samples for AC and sRAGE levels were collected both preopertively and postoperatively. The CAM ICU and MDAS were used within the first 5 days postoperatively to screen for a diagnosis of delirium.ResultsPostoperative delirium developed in 34% (61 of 177) of participants. Multivariate stepwise logistic regression analysis revealed that patients with low baseline AC are at significantly increased risk of developing delirium. Moreover, preoperative AC levels were inversly correlated with postoperative sRAGE concentrations (Spearman’s Rank Correlation -0.198; p<0.05). The most optimal cutoff values of the preoperative and postoperative AC that predict the development of delirium were 1.720 mM and 1.893 mM, respectively.ConclusionsDecreased plasma AC levels are associated with delirium after cardiac surgery and inversly correlated with post-surgery sRAGE concentration. This may be an important pathophysiological consideration in the increased risk of postoperative delirium seen in cardiac surgery patients.
Structure of personal disorders in hypertensive disease patients
Authors: Chernus N. , .Sivkov S. , Serdakova A. , Sivkov A. , Savina T. 
Published: February 2022

IntroductionThe strcuture of personal disorders in hypertensive disease aptients remains relevant topic.ObjectivesThe study population included 57 hypertensive disease patients; mean age 49,1+9,6 years old (42 females and 15 males). The control group included 62 healthy individuals (49 females and 13 males); mean age 48,1+8,6 years old.MethodsEmotional condition of subjects was assessed using the Depression Scale of Zung, the Spielberger trait Anger scale and Anxiety, the Toronto Alexithymia Scale and SCL – 90-R Questionnaire.ResultsThe study results showed that as compared to the healthy individuals, the hypertensive disease patients showed significantly higher scores of reactive anxiety (46,0+9,0 and 39,0+8,2; р<0,01), personal anxiety (50,3+9,2 and 41,03+7,9; р<0,01), depression (42,7+7,2 and 36,59+5,95;р<0,01), alexithymia (69,4+8,8 and 59,0+9,2; р<0,01), state anger (11,8+3,6 and 10,6+1,8; р<0,01), reactive anger (9,2+2,6 and 8,1+2,4; р<0,05), personal anger (21,4+5,3 and 18,1+4,6; р<0,01), trait anger (8,3+3,0 and 7,3+2,3; р<0,05), self-aggression (16,2+4,9 and 13,4+3,8; р<0,01), aggression towards others (15,9+3,9 and 14,7+3,4; р<0,05), somatization (1,27+0,6 and 0,5+0,4; р<0,01), hostility (1,2+0,7 and 0,5+0,4; р<0,01), obsessive-compulsive traits (1,2+0,7 и 0,6+0,4; р<0,01), psychoticism (0,7+0,6 and 0,27+0,30; р<0,01) and paranoid traits (1,22+0,6 and 0,5+0,4; р<0,01), phobic anxiety (0,6+0,5 and 0,2+0,2; р<0,01) and interpersonal sensitivity (1,2+0,7 and 0,7+0,5; р<0,01).ConclusionsClose interrelations between manifestations of anxiety and depression spectrum disorders and anger may be explained by internal conflict between aggressive impulses and the need for adaptive behavior in such individuals, resulting in consistent vicious vortex.
Psychological well-being and employment status during the COVID-19 pandemic
Authors: Valenzuela P. , Barrientos C. , Molina F. , Valdés D. , Leniz I. , Reginatto G. , Basaigoitia A. , Solis-Soto M. , Burrone M. 
Published: February 2022

IntroductionSeveral restrictive measures have been implemented to reduced COVID- 19 impact with unknown consequences on people daily life.ObjectivesThe primary objective is to asses the psychosocial impact and employment status changes since lockdown COVID-19 measures in Chile.MethodsCross-sectional study was implemented using an anonymous and self-administered online questionnaire. Adult people were invited to participate through social networks between May to June 2020. The questionnaire included sociodemographic information, coping strategies, changes in income and working conditions and psychological distress (K10 Scale).Results
3102 participants over 18 years answered the questionnaire. 69.9% reported psychological distress mainly women (82.2%), members of the public health system (59%), dependent workers (39.8%), people who suffered income reduction (36.8%)., and those who changed their employment status (26.4%). Participants who presented income reduction were 1.83 times more likely to present psychological distress than those without changes (p <0.001)ConclusionsPandemic crisis had impacted population health, especially in some specifics groups that could be targeted for future interventions.
Anxiety and coping in the situation of pandemic as factors of sleep-related complaints during lockdown
Authors: Rasskazova E. , Yavorovskaya A. 
Published: February 2022

IntroductionSleep-related complaints are among the most common during pandemic, along with anxiety and depression (Huang, Zhao 2020, Rajkumar 2020). Their prevalence is associated with anxiety about the pandemic (Roy et al., 2020), online information search (Moghanibashi-Mansourieh, 2020, Wang et al., 2020).ObjectivesThe aim was to reveal relationship between the type anxiety and coping during pandemic and sleep-related complaints after 3-4 weeks of lockdown.Methods
203 adults aged 18 to 59 years filled situational version COPE (Carver et al., 1989) and scales measuring anxiety of infection and pandemic consequences (Tkhostov, Rasskazova, 2020) in the mid-April 2020 after 2-3 weeks of lockdown in Russia. After 3-4 weeks, they filled in a modified insomnia severity index (Morin, 1991) appraising how much worse their sleep and daytime functioning during this period (Cronbach’s alpha .62-.73).ResultsPrevalence of sleep and day functioning related complaints during lockdown varied 19.3%-30.5%. Complaints were associated with anxiety only if it reaches dysfunctional level (interfering with daily activities, r = .17-.34, p <.05) and coping strategy of mental disengagement (r = .15-.19, p <.05). Sleep complaints were related to substance use to cope with lockdown problems while complaints on daytime functioning correlated were more common among young respondents (r = -0.22, p <0.01).ConclusionsComplaints about poor sleep during a pandemic are not related to the general severity of pandemic anxiety, but to the dysfunctional level of anxiety and attempts to avoid it. Research is supported by the Russian Foundation for Basic Research, project No. 20-013-00740.Conflict of interestResearch is supported by the Russian Foundation for Basic Research, project No. 20-013-00740.
Post-discharge depressive symptoms and health-related quality of life of critical COVID-19 survivors
Authors: Martins S. , Ferreira A.R. , Fernandes J. , Vieira T. , Fontes L. , Coimbra I. , Paiva J. , Fernandes L. 
Published: February 2022

IntroductionSurvivors of critical illness stay frequently experience long-term mental health morbidity, suggesting that many critically ill patients with COVID-19 may also show a high prevalence of psychiatric conditions.ObjectivesTo describe depression in COVID-19 survivors 4-months post-hospital discharge and to examine its association with health-related quality of life (HRQoL).MethodsThis pilot study involved COVID-19 adult patients admitted in Intensive Care Medicine Service (ICMS) of a University Hospital. Exclusion criteria were: ICMS length of stay (LoS)≤24h, terminal illness, major sensory loss and inability to communicate at the time of assessment. All participants were evaluated at ICMS scheduled telephone follow-up appointment, with Patient Health Questionnaire (PHQ-9) (depression) and EQ-5D-5L (HRQoL). Critical-illness severity was assessed with APACHE-II and SAPS-II.Results
Twenty patients were included with a median age of 62(range: 24-77) y.o., the majority male (75%) and married (70%). Median (range) APACHE-II and SAPS-II was 17 (5-34) and 32.5 (7-77), respectively, and LoS was 18 (4-58) days. Overall, 25% patients presented depression symptoms and most reported problems on EQ-5D-5L domains of pain/discomfort (65%), anxiety/depression (55%) and mobility (50%). Depression scores were higher in patients with problems in EQ-5D-5L domains of usual activities (median 4 vs 1.5; p=0.046), pain/discomfort (median 0 vs 4; p=0.004) and anxiety/depression (median 4 vs 0;p<0.001).ConclusionsThese preliminary findings show that depression is frequent in COVID-19 survivors and it is associated with worse HRQoL. This pilot study highlights the importance of psychological assessment and treatment of COVID-19 survivors, in order to minimize its negative impact on HRQoL, optimizing their recovery.
Psychopathological consequences related to COVID-19 infection: The most relevant reactions of the general population
Authors: Serafini G. , Aguglia A. , Amerio A. , Sher L. , Amore M. 
Published: February 2022

IntroductionAs a result of the emergence of coronavirus disease 2019 (COVID-19) outbreak caused by acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the Chinese city of Wuhan, a situation of socio-economic crisis and profound psychological distress rapidly occurred worldwide.ObjectivesThis work aimed to comprehensively review the current literature about the impact of COVID-19 infection on the mental health in the general population.MethodsA detailed review has been conducted in order to identify the main psychopatological consequences related to Covid-19 infection in the general population.ResultsVarious psychological problems and important consequences in terms of mental health including stress, anxiety, depression, frustration, uncertainty during COVID-19 outbreak emerged progressively. The psychological impact of quarantine related to COVID-19 infection has been additionally documented together with the most relevant psychological reactions in the general population related to COVID-19 outbreak.Conclusions
The role of risk and protective factors against the potential to develop psychiatric disorders in vulnerable individuals with Covid-19 infection need to be carefully addressed in the clinical practice.
The experience of northern italy in elderly patients with COVID-19 infection and mental disorders
Authors: Serafini G. , Bondi E. , Locatelli C. , Amore M. 
Published: February 2022

IntroductionIn December 2019, the first cases of Corona Virus Disease 2019 (COVID-19) outbreak related to acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were reported in the Chinese city of Wuhan. European countries experienced a tragic growth in the number of Covid-19 cases although several restrictions have been imposed.ObjectivesThe study is aimed to describe the first experience of the Hospital Papa Giovanni XXIII in the city of Bergamo, Northern Italy.MethodsThe most relevant clinical characteristics of aged patients with COVID-19 and mental disorders have been described.Results
According to the experience of the Hospital Papa Giovanni XXIII, medical departments, after appropriate training of all healthcare workers, have been rapidly converted into specific units aimed at treating patients with COVID-19 infection. Specifically, we directly observed a rapidly growing request of psychiatric interventions in aged patients with COVID-19 infection due to the emergence of severe delirium (mainly hyperkinetic) which was reported in approximately 30−50% of cases increasing with age, psychomotor agitation, anxiety, and depressive symptoms. When compared with younger subjects, we found that subjects aged 65 or above with prolonged hospitalization in our hospital are more vulnerable to: 1) environmental factors (e.g., social isolation and distance from family members, stay in intensive/subintensive units, communication difficulties due to therapeutic devices); 2) individual factors (e.g., COVID-19 possible neurotropic properties, impairments in insight and cognitive dysfunctions, comorbid medical conditions, and use of multiple medications).ConclusionsThe main implications of the present findings have been discussed.
Reconceptualising the DSM: Neuroanalysis and digital brain profiling
Authors: Peled A. 
Published: February 2022

Recent years have seen a great advancement in the emerging field of Neural Computation, a study of the brain using neuronal network models. As a consequence, another field of science is being developed titled ‘Computational Psychiatry’ where neuronal network models of psychopathology help understand the possible etiology for mental disorders. With Computational Psychiatry we can begin and reformulate mental disorders as brain disorders. Etiological diagnosis in psychiatry will be the next breakthrough which will allow to effectively treat mental disorders and will bring psychiatry back to the realm of medicine Computational Psychiatry together with advances in technology, will transform psychiatry beyond recognition: With the development of the connecting internet and sensor technology (e.g., face speech recognition) mental status examination can be easily extracted and delivered over distance (tele-psychiatry). With the help of AI the extracted psychiatric phenomenology can be interpreted to match most of the diagnostic process of a skilled psychiatrist. Once achieved a continual psychiatric monitoring coupled with new technology of wireless dry-electrode electrophysiological brain imaging can begin and collect big-data. Big-data analysis stand a good chance to reveal the etiological correlations between mental disorders and their brain-related origins. Thus, etiology for mental disorders can begin to unravel. Neural modulation technology will be the answer for effective therapeutic interventions (i.e., future brain pacers).DisclosureI am in a preliminary effort to develop a Digital application in the field of Psychiatry
Burn-out syndrome in healthcare practitioners- a narrative literature review
Authors: Vasiliu O. 
Published: February 2022

IntroductionBurn-out syndrome is an underestimated entity in the medical environment, and lack of health policies for screening, prevention and early phase treatment strategies may be responsable for complications of this syndrome, e.g. major depression, substance use disorders, or anxiety disorders. Large variations in the estimation of burn-out prevalence in healthcare providers may be related to poorly designed epidemiological trials and lack of well-defined criteria for diagnosis.ObjectivesTo analyse the current evidence in the literature about the diagnosis and treatment of burn-out syndrome in physicians and auxiliary personnel.Methods
A literature review was performed through the main medical databases (Cochrane Database of Systematic reviews, PubMed, Thomson Reuters/Web of Science, SCOPUS, EMBASE, CINAHL) using the search paradigm “burn-out” AND “healthcare providers” OR “physicians” AND “nurses”. All papers published between January 2000 and August 2020 were included in the primary analysis.Results
A large number of papers were detected in the primary analysis (n=245), but only 15 remained after the inclusion/exclusion criteria were applied. Maslach Inventory for Burnout is the most extensively used instrument for screening, but its validity is questioned, and new instruments have been created, but less frequently applied. Cognitive behavioral therapy led to improvement of the emotional exhaustion in multiple trials. Meditation techniques, music therapy, structured physical exercises, and management-related interventions have been associated with low to moderate degree of success.ConclusionsBurn-out syndrome is a still insufficiently explored diagnosis and more good-quality epidemiological and clinical trials are needed in order to support adequate prevention and treatment strategies.
Online group psychotherapy for patients with binge eating disorder during COVID-19 emergency
Authors: Focà F. , Santucci F.R. , Ferretti S. , Rinaldi L. , Sani G. , Janiri L. , Chieffo D.P.R. 
Published: February 2022

IntroductionOn March 13th 2020, in execution of the Law Decree 14/2020 regarding the reorganization of National Health Care related to COVID-19 emergency, all non-urgent outpatient healthcare services were suspended in Italy. The present work describes remote support and online group psychotherapy set in motion during COVID-19 emergency for outpatients with Binge Eating Disorder.ObjectivesAim of the present work is to describe and evaluate online support and group psychotherapy for outpatients with Binge Eating Disorder during lockdown due to COVID-19 emergency. Outcomes were evaluated by remote administration of questionnaires.Methods20 outpatients with Binge Eating Disorder, treated by psychotherapists of Hospital Psychology Unit in Psychiatry Day Hospital of an Italian General Hospital, received remote support by phone calls and online group psychotherapy from march to may 2020. During the first two weeks, patients were supported via phone calls. From the third week on, they took part to online group psychotherapy sessions, held every week at the same day and time. Pre-post remote administration of Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM) and the Questionnaire of Eating Behaviours (Scheda dei Comportamenti Alimentari, SCA) was used to evaluate outcomes. Data were analyzed by Student’s t-test.ResultsNo significant difference was found, thus indicating stability of symptomatology.ConclusionsLockdown was a highly stressful period, in which many people lost control on eating behaviours and those with Binge Eating Disorder were expected to have an exacerbation of symptoms. Remote support and online group psychotherapy proved effective in protecting patients from a possible aggravation of their condition.
Difficulties in maintaining electroconvulsive treatment (ECT) in a psychiatric hospital during covid19 pandemic
Authors: Rojo M. , Constantin M. , Langree B. , Marie N. , Bellay R. 
Published: February 2022

IntroductionECT is an effective care with high level of recommendation. During the COVID19, new recommendations to protect patients and caregivers combined with the increasing use of medicines and medical devices (MD) for anesthesia, caused greater difficulties of supply. Even if vital for patients, it is challenging to maintain ECT in this environment.ObjectivesThe aim of this study is to resume the measures implemented in order to maintain ECT during COVID19.MethodsRetrospective analysis of measures implemented to maintain the ECT during COVID19.Results

As FFP2 masks were restricted to intensive care units, our hospital were not supplied. After negotiations, the regional health agency (ARS) has granted us an allocation of 100 masks to maintain ECT. Our efficient stock management of personal protective equipment as well as our transparency on these stocks with ARS and sharing with other hospitals out of stock played a role in this agreement.We had to adapt our MDs references according to breaks of many ones and new recommendations. The university hospital helping us in supplying certain missing references. Considering the difficulties in supplying drugs and MDs, and limited availability of anesthetists, we have reduced the number of ECT. Prioritization of patients with vital indications had to be achieved.ConclusionsThe prioritization of some services by the regulatory agency causes many supply difficulties for the others. It would be important to reassess the priority of ECT in such crisis because most of the time other caregivers and regulatory agencies are not aware how they are vital for patients.
Symptoms of depression and anxiety among health care workers during COVID-19 pandemia in latvia: A cohort study
Authors: Valaine L. , Ancans A. , Logina L. , Beskrovniijs R. , Bubko L. , Ancane G. 
Published: February 2022

IntroductionStudies from the beginning of 2020 show that symptoms of depression and anxiety are increasing among health care workers. It is important to assess the dynamics of health care workers mental health.ObjectivesTo assess the dynamic of symptoms of depression and anxiety among health care workers over a 3-month period during the COVID-19 pandemia in Latvia.Methods
A longitudinal cohort study of symptoms of depression and anxiety in the population of physicians, physician assistants and nurses in Latvia during the COVID-19 pandemia. Symptoms of depression were assessed using the Patient Health Questionnaire-9 (PHQ-9) scale, symptoms of anxiety were assessed using the General Anxiety Disorder (GAD-7) scale, cut-off score for both scales was 10. Initial data was collected on April-May 2020 with a 3 month follow-up.. Data was analyzed using SPSS- Related-Samples McNemar test.Results348 physicians were initially included (women 83,9%, mean age 45,17±14,02) and 376 physicians assistants and nurses (women 88,2%, mean age 39,99±12,97). After the 3-month follow up 189 physicians (women 88,40%, mean age 45,01±13,57) and 141 physicians assistants and nurses were left (women 88,00%, mean age 39,96 ±12,59). During the 3 months symptoms of depression among physicians rose from 26,80% (n=94) to 27,5% (n=52), symptoms of anxiety from 17,70% (n=62) to 20,6% (n=39). Depression symptoms among physician assistants and nurses dropped from 25,50% (n=96) to 23,9% (n=34), symptoms of anxiety stayed almost the same 18,20% (n=68) to 18,30% (n=26). Symptoms of depression among physicians changed from 26,80% (n=94) to 27,5% (n=52), symptoms of anxiety from 17,70% (n=62) to 20,6% (n=39), changes were not statistically significant (p=0,281; p=0,725). Symptoms of depression among physician assistants and nurses changed from 25,50% (n=96) to 23,9% (n=34), symptoms of anxiety from 18,20% (n=68) to 18,30% (n=26), changes were not statistically significant (p=0,405; p=0,664).ConclusionsNo change in the dynamics of symptoms of depression and anxiety among health care workers over a 3-month period during the COVID-19 pandemia in Latvia was observed.