bluuebunny/crossref_metadata_2025_split huggingface dataset:
Searching for Borders of Freedom: Foreign Trips of Czechoslovak Musicians and Athletes between 1948–1989
Authors: Mücke Pavel , Krátká Lenka 
Published: November 2022

Abstract
In the era of the “people’s democratic” and later “socialist” Czechoslovakia (1948–1989), foreign trips, and even more business trips because of their financial impact on one’s life, represented privileges that were to be granted by the ruling elites only to reliable and closely-watched Czechoslovak citizens in the name of the “public interest.” At the same time, the business trips became a kind of litmus test of the loyalty and the “importance” of the travelling (in case of disapproval, non-travelling) individual in the regime’s eyes. In this context, the paper focuses on the lived experience of musicians and athletes concerning foreign trips. Finally, it discusses the potential contradictions between some popular stories in the Czech collective memory on the one hand and more detailed micro-historical probes on the other hand, which demonstrate the interpretive richness of the discussed issues.
Supporting Curriculum Innovation in Integrated STEM for Secondary Teachers in Australia
Authors: Anderson Judy , Tytler Russell , Williams Gaye 
Published: November 2022

Abstract
Given concerns in the Australian context about students’ attitudes and declining participation in STEM subjects in the senior secondary years, a range of initiatives have been developed to support teacher design of innovative STEM curriculum and pedagogy. The STEM Academy program worked with interdisciplinary teams of secondary STEM teachers to develop teacher capacity to create real-world, challenging problems to engage and motivate their students. Questionnaire and interview data collected from one cohort of 70 teachers from twelve schools, three program facilitators, and school leaders provided a case study revealing themes about the nature of the journey, the role of the program and the processes and varied nature of schools’ STEM curriculum innovations. An innovation framework was used to make sense of teachers’ journeys towards effective and sustainable STEM practices leading to the identification of three models that reflected different approaches to the challenge of representing STEM within subject-based curricular settings.
The analgesic Efficacy and Safety of Topically Applied Tramadol in Peritonsillar Space During Pediatric Adenotonsillectomy: A Meta-Analysis
Authors: Kang Yun Jin , Cho Jin-Hee , Hwang Se Hwan 
Published: November 2022

Objectives: To evaluate the efficacy of topically applied tramadol in peritonsillar area for pain control and induction of perioperative morbidity in children undergoing adenotonsillectomy. Methods: Two authors independently searched the databases (MEDLINE, SCOPUS, and Cochrane databases) up to April 2022 for randomized controlled trials comparing the efficacy of an intraoperative peritonsillar administered tramadol with placebo or other agents only in pediatric patients. The outcomes were postoperative pain scores, time to take the first pain reducing drugs, and postoperative nausea/vomiting. Results: Our analysis was based on 17 trials. Peritonsillar administered tramadol significantly reduced postoperative pain at less than 20 minutes (SMD −1.5852, 95% CI [−2.3900; −0.7804]), 1 hour (SMD −1.5811, 95% CI [−2.3400; −0.8222]), 8 hours (SMD −1.0258, 95% CI [−1.8792; −0.1724]), 16 hours (SMD −0.8397, 95% CI [−1.4266; −0.2529]), and 1 day (SMD −1.0110, 95% CI [−1.5213; −0.5007]) and the time to take the first analgesic drug (SMD 1.6565, 95% CI [0.2838; 3.0293]) compared with the placebo. However, tramadol showed no significant difference on postoperative pain relief effects and the time to take the first analgesic drug compared to the other topical agents (bupivacaine, lidocaine, ketamine, and dexamethasone). Tramadol did not cause significant postoperative nausea and vomiting. Conclusions: This study demonstrated that intraoperatively applied topical tramadol could control postoperative pain and reduce the analgesic uptake compared with a control. However, the efficacy of tramadol in pain control was similar to other agents in pediatric adenotonsillectomy.
The National Institute for Occupational Safety and Health (NIOSH) Recommended Weight Generates Different Spine Loads in Load-Handling Activity Performed Using Stoop, Semi-squat and Full-Squat Techniques; a Full-Body Musculoskeletal Model Study
Authors: Dehghan Parisa , Arjmand Navid 
Published: November 2022

Objective Adequacy of the Revised NIOSH Lifting Equation (RNLE) in maintaining lumbosacral (L5-S1) loads below their recommended action limits in stoop, full-squat, and semi-squat load-handling activities was investigated using a full-body musculoskeletal model. Background The NIOSH committee did not consider the lifting technique adapted by workers when estimating the recommended weight limit (RWL). It is currently unknown whether the lifting technique adapted by workers would affect the competence of the RNLE in keeping spine loads below their recommended limits. Method A full-body subject-specific musculoskeletal model (Anybody Modeling System, AMS) driven by a 10-camera Vicon motion capture system (Vicon Motion Systems Inc., Oxford, UK) was used to simulate different static stoop, semi-squat, and full-squat load-handling activities of ten normal-weight volunteers (mean of ∼70 kg corresponding to the 15th percentile of adult American males) with the task-specific NIOSH RWL held in hands. Results Two-way repeated measures ANOVA revealed a significant effect of lifting technique on both the L5-S1 compression ( p = 0.003) and shear ( p = 0.004) loads with semi-squat technique resulting in significantly larger loads than both stoop and full-squat techniques ( p < 0.05). While mean of L5-S1 loads remained smaller than their recommended limits, it is much expected that they pass these limits for heavier individuals, that is, for the 50th percentile of adult American males. Conclusion Spinal loads are expected to pass their recommended limits for heavier individuals especially during semi-squat lifting as the most frequently adapted technique by workers. Application Caution is required for the assessment of semi-squat lifting activities by the RNLE.
Effectiveness and safety of the direct oral anticoagulant in acute distal deep vein thrombosis: From the prospective multicenter observational study, J’xactly, in Japan
Authors: Mo Makoto , Fukuda Ikuo , Nakamura Mashio , Yamada Norikazu , Takayama Morimasa , Maeda Hideaki , Yamashita Takeshi , Ikeda Takanori , Yamazaki Tsutomu , Okumura Yasuo , Hirayama Atsushi ,   on behalf of the J’xactly Investigators
Published: November 2022

Objectives We assessed the effectiveness and safety of rivaroxaban in patients with isolated distal deep vein thrombosis (IDDVT). Methods Symptomatic venous thromboembolism (VTE) and major bleeding were assessed. Results Of 1016 patients with acute symptomatic/asymptomatic DVT and/or pulmonary embolism treated with rivaroxaban, 288 had IDDVT and 294 had proximal DVT (pDVT). The IDDVT group had fewer patients on the higher rivaroxaban dose (30 mg/day) (42.7% vs. 66.0%) and a shorter treatment duration (135.5 vs 369.5 days) than the pDVT group. VTE recurrence occurred in 14 and 11 patients with IDDVT and pDVT, respectively (2.89% vs. 2.29% per patient-year; p = 0.534). Major bleeding was less frequent in the IDDVT group (1.55% vs. 4.53% per patient-year; p = 0.044). Comparable effectiveness and safety were observed with 15 and 30 mg/day rivaroxaban in the IDDVT group. Conclusions Short-term, low-dose rivaroxaban seems safe and effective for IDDVT treatment.
LGBT+ partner bereavement and appraisal of the Acceptance-Disclosure Model of LGBT+ bereavement: A qualitative interview study
Authors: Bristowe Katherine , Timmins Liadh , Braybrook Debbie , Marshall Steve , Pitman Alexandra , Johnson Katherine , Day Elizabeth , Clift Paul , Rose Ruth , Yi Deokhee , Yu Peihan , Gao Wei , Roach Anna , Almack Kathryn , King Michael , Harding Richard 
Published: November 2022

Background: Support from social networks is vital after the death of a partner. Lesbian, gay, bisexual and/or transgender (LGBT+) people can face disenfranchisement and isolation in bereavement. The Acceptance-Disclosure Model (of LGBT+ bereavement) posits that experiences are shaped by the extent to which individuals feel able to disclose their bereavement to others, and whether that loss is acknowledged appropriately. Aim: To explore LGBT+ specific experiences of partner bereavement; determine decision-making processes regarding disclosure of relationships/identities; and appraise the Acceptance-Disclosure Model using primary qualitative data. Design: Exploratory in-depth qualitative interview study positioned within a social constructivist paradigm. Data were analysed using inductive and deductive reflexive thematic analysis. Setting/participants: 21 LGBT+ people from across England bereaved of their civil partner/spouse. Results: Participants described LGBT+ specific stressors in bereavement: lack of recognition of their loss; inappropriate questioning; unwanted disclosure of gender history; and fears of discrimination when accessing support. Disclosure of LGBT+ identities varied across social networks. Some participants described hiding their identities and bereavement to preserve relationships, and challenging intersections between LGBT+ identities and other aspects of culture or self. These findings provide primary evidence to support the Acceptance-Disclosure Model. Conclusions: LGBT+ people face additional stressors in bereavement. Not all LGBT+ people want to talk directly about their relationships/identities. Sensitive exploration of support needs, aligned with preferences around disclosure of identities, can help foster trust. Five recommendations for inclusive practice are presented. Further research should consider whether the Acceptance-Disclosure Model has utility to explain bereavement experiences for other isolated or disenfranchised groups.
A qualitative service evaluation of patient and caregiver experiences of CAR-T therapy: Recommendations for service development and implications for palliative care teams
Authors: Stenson Charlotte L , Vidrine Jennifer , Dewhurst Felicity , Osborne Wendy , Menne Tobias , Stocker Rachel 
Published: November 2022

Background: Chimeric Antigen-Receptor-T-cell (CAR-T) therapy is a potentially life-saving treatment for refractory haematological malignancies. Internationally, CAR-T services are undergoing rapid development. Despite this, research on the lived experiences of patients receiving novel immunotherapies is limited. Little is known about their supportive care needs. Consequently, dedicated palliative and supportive care services may not be considered. Aim: To explore the patient and caregiver experience of CAR-T therapy and identify unmet needs to inform service development. Design: A qualitative longitudinal service evaluation. Sixteen interviews were conducted between December 2020 and March 2021 with patients ( n = 10) and family caregivers ( n = 4). Thematic analysis was underpinned by a constructivist approach. Setting/participants: All patients and caregivers attending one UK centre for CAR-T therapy were eligible. Semi-structured interviews were conducted at specific time points: prior to infusion, one month after infusion and follow-up post-treatment (5–18 months). Results: Identified themes described the unique challenges of CAR-T therapy. From the point of referral patients had a wide range of supportive care needs. Initially, this was attributed to prior receipt of multiple failed treatments. Subsequently, CAR-T side-effects impacted on quality-of-life and physical function. Significant psychological morbidity from prognostic uncertainty was described throughout. Patients and caregivers reported that a dedicated nurse specialist – an expert, consistent point of contact – was essential. Conclusion: Patients and caregivers would benefit from early and ongoing support from palliative care, allied-health professionals and psychology. As indications for CAR-T therapy expand, there is an urgent need for multi-centre studies incorporating patient-reported outcome data to ensure patient-centred service delivery.
Changes in music-evoked emotion and ventral striatal functional connectivity after psilocybin therapy for depression
Authors: Shukuroglou Melissa , Roseman Leor , Wall Matt , Nutt David , Kaelen Mendel , Carhart-Harris Robin 
Published: November 2022

Background: Music listening is a staple and valued component of psychedelic therapy, and previous work has shown that psychedelics can acutely enhance music-evoked emotion. Aims: The present study sought to examine subjective responses to music before and after psilocybin therapy for treatment-resistant depression, while functional magnetic resonance imaging (fMRI) data was acquired. Methods: Nineteen patients with treatment-resistant depression received a low oral dose (10 mg) of psilocybin, and a high dose (25 mg) 1 week later. fMRI was performed 1 week prior to the first dosing session and 1 day after the second. Two scans were conducted on each day: one with music and one without. Visual analogue scale ratings of music-evoked ‘pleasure’ plus ratings of other evoked emotions (21-item Geneva Emotional Music Scale) were completed after each scan. Given its role in musical reward, the nucleus accumbens (NAc) was chosen as region of interest for functional connectivity (FC) analyses. Effects of drug (vs placebo) and music (vs no music) on subjective and FC outcomes were assessed. Anhedonia symptoms were assessed pre- and post-treatment (Snaith–Hamilton Pleasure Scale). Results: Results revealed a significant increase in music-evoked emotion following treatment with psilocybin that correlated with post-treatment reductions in anhedonia. A post-treatment reduction in NAc FC with areas resembling the default mode network was observed during music listening (vs no music). Conclusion: These results are consistent with current thinking on the role of psychedelics in enhancing music-evoked pleasure and provide some new insight into correlative brain mechanisms.
Cytotoxic effects of crystalline silica in form of micro and nanoparticles on the human lung cell line A549
Authors: Rafieepour Athena , R Azari Mansour , Khodagholi Fariba 
Published: November 2022

Airborne crystalline silica (SiO2) particles are one of the most common pollutants in stone industries. Limited studies have investigated the health effects of crystalline SiO2 nanoparticles. Hence, the objective of this study was to study the cytotoxicity of SiO2 in nano and micron sizes. A mineral quartz sample in the range of 0.2–0.8 mm sizes was purchased. These particles were ground at about 5 and 0.1 microns. Human cell line A549 was exposed to micro and nanometer particles at concentrations of 10, 50, 100, and 250 μg/ml for 24 and 72 h. Subsequently, the cytotoxicity of exposed cells was investigated by measuring cell survival, ROS generation, mitochondrial permeability, and intracellular glutathione content. The results showed that crystalline SiO2 nano and microparticles decreased cell survival, increased ROS generation, damaged the mitochondrial membrane, and lowered the antioxidant content of these cells in a concentration- and time-dependent manner. The toxicity of crystalline SiO2 microparticles at concentrations ≤50 μg/mL was greater than for nanoparticles, which was the opposite at concentrations ≥100 μg/mL. Exposure time and concentration were crucial factors for the cytotoxicity of exposed A549 cells to crystalline SiO2 particles, which can affect the severity of the effect of particle size. Due to the limitation of exposure concentration and test durations in this study, further studies on the parameters of nanoparticle toxicity and underlying mechanisms could advance our knowledge.
Cervical Cancer-Related Knowledge, Attitudes, Practices and Self-Screening Acceptance Among Patients, Employees, and Social Media Followers of Major Brazilian Hospital
Authors: Perez Luiza , Tran Kimberley , Alvarenga-Bezerra Vanessa , Chadha Diya , Dotson Libby , Assir Fernanda , Cordioli Eduardo , Tamura Vieira Gomes Mariano , Podgaec Sergio , Lopes da Silva-Filho Agnaldo , Ramanujam Nimmi , Moretti-Marques Renato 
Published: November 2022

Background Brazil has a high burden of cervical cancer, even though it is preventable, traceable and treatable. Hence, this study evaluated levels of knowledge, attitudes and practices (KAP) related to cervical cancer screening and diagnosis and acceptance of self-screening techniques among women aged 24 and greater. Methods A cross-sectional KAP survey was administered to n = 4206 women and spanned questions relating to cervical cancer, HPV, speculum, Pap test and colposcopy. Questionnaire was disseminated through a major hospital’s social media platforms, intranet and gynecologic-oncology clinics. Logistic regressions evaluated associations between sociodemographic characteristics and knowledge, attitudes, and preventative behaviors against cervical cancer. Participants indicated willingness to try DNA-HPV self-sampling and cervix self-visualization (self-colposcopy). Findings Participants were mostly white individuals (70.5%) with higher education and from social classes A and B. They demonstrated superior levels of KAP than described in the literature, with over 57.8% having answered 80+% of questions correctly. KAP scores were predicted by social class, educational attainment, race, history of premalignant cervical lesions and geographic location. About 80% and 63% would be willing to try DNA-HPV self-sampling and cervix self-visualization, respectively. Interest in self-screening was associated with adequate attitude (OR = 1.85) and inadequate practice (OR = .83). Interpretation Adequate KAP are fundamental for the successful implementation of a self-screening program. Participants were interested in methods that provide them with greater autonomy, control and practicality. Self-screening could address barriers for under-screened women such as shame, discomfort, distance from clinics and competing commitments, enabling Brazil to reach the WHO’s cervical cancer elimination goals. It could also decrease excess medical intervention in over-screened populations by promoting shared decision-making.
The impact of stent-graft sizing on venous stenosis re-intervention and arteriovenous graft patency: Free-floating stent outflow is associated with improved outcomes
Authors: Stove Callum , Kingsmore David B , Stevenson Karen S , Thomson Peter C , Nath Alex , Kasthuri Ram 
Published: November 2022

Background: Early cannulation arteriovenous grafts (ecAVG) for dialysis access are limited by reintervention for venous stenosis (VS) despite their good initial patency. Whilst stent-grafts (SG) have shown promise, the optimal sizing is unclear. Therefore, this study aims to determine if outflow vein diameter, SG diameter or these relative to each other (V:Sr) alters outcomes, and if so, which is more important. Methods: Retrospective analysis was performed of Gore® Acuseal® ecAVGs with VS treated with Gore® Viabahn® SG over a 7-year period. Primary patency (PP), time to thrombosis and functional patency were analysed by SG length/diameter, vein diameter and V:Sr. Results: We identified 114 ecAVGs with median follow-up 492 days (IQR 189–770). SG length and diameter did not correlate with PP, however, there was a significant relationship between vein diameter and PP (RR = 0.901 (0.832–0.975), p = 0.01) and between V:Sr and PP (RR = 0.462 (0.255–0.838), x2 = 5.866, p = 0.0015). The optimal V:Sr was ⩾1.4 (i.e. vein diameter at least 40% greater than the stent-graft; or ‘free-floating’ stent outflow) (RR = 2.759 (1.670–4.558), p < 0.001), translating to a difference in median PP of 252 versus 496 days (IQR: 188–316; 322–670). On multivariate analysis, absolute vein diameter lost significance, whilst V:Sr remained an independently significant predictor of PP (RR = 3.247 (1.560–6.759), p = 0.02). Conclusions: Placement of the SG outflow into a relatively larger segment of vein was associated with a significant increase in PP independent of the absolute vein diameter. This suggests that larger calibre SG which are apposed to the vein wall are not required for optimal primary patency, and indeed should be actively avoided. Instead, a ‘free-floating’ stent outflow which is undersized relative to the recipient vein (whilst maintaining a minimum anchoring calibre) is recommended where possible. This should be considered during intervention and may require selection of longer devices, where practical, to bring the stent outflow into a larger vein segment. Level of Evidence: Level 3a, Non-randomised controlled cohort/follow-up study
Effects of injection styles on heating performance of a heat pump with sub-cooler refrigerant injection: Experimental and thermodynamic analysis
Authors: Zhang Lina , Tu Qiu , Yuan Xiaoyuan , Wu Xiaogang 
Published: November 2022

The performance improvement of heat pump depends on the appropriate injection style such as liquid injection, vapour injection and two-phase injection. In this work, experimental and theoretical investigation on the heat pump with R410A refrigerant reveals three kinds of injection styles can be selectively achieved in the same injection device by suitable control of the sub-cooling electronic expansion valve. Liquid injection and vapour injection improve the heating capacity (Qh), mainly due to the increase of heat exchange in the sub-cooler and compressor compression work, respectively. Two-phase injection lifts the Qh owing to these two effects. Subsequently, the effect of two-phase injection on improving the heat pump performance is superior to the other two injection styles. For instance, the maximum Qh were 14.4 kW at 60 rps with the liquid injection, 12.5 kW and 13.4 kW at 85 rps with vapour injection and two-phase injection, and 8.1%, 7.0% and 18.3% higher than those without injection, respectively. The corresponding coefficient of performance was improved by 10.4%, 4.5% and 10.6%, respectively. Furthermore, the model based on the pressure-enthalpy diagram has been developed to analyze the experimental results and expound the main factors affecting the heat pump performance under different ambient temperatures.