bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Printing of Thiol‐Yne Photoresins through Visible Light Photoredox Catalysis
Authors: Wu Yimei , Simpson M. Cather , Jin Jianyong 
Published: March 2022

AbstractIn this work, we report a visible light active thiol‐yne photoresin formulation that is printable with digital light processing (DLP) 3D printer under irradiation of blue‐light (λmax=470 nm). The resulting objects have the Z axis resolution of 250 μm (layer thickness) and building speed of (5 mm/h). Uniquely, our thiol‐yne photoresin contains photoredox catalysts Eosin Y and fac‐Ir(ppy)3, which initiate the photopolymerization through a photoredox mechanism. The optimized dual catalysts EY/fac‐Ir(ppy)3 system not only facilitate the faster thiol‐yne reaction but also potentially enables wider visible light wavelength coverage for 3D printing process. This work illustrates the possibility of replacing traditional photoinitiator with photoredox catalysts in the visible light range, thus, enriching the photoresin formulations for polymer‐based 3D printing industry.
Visible light driven instantaneous photocatalytic degradation of aniline blue (AB) and methyl violet (MV) by strontium ferrite nanoparticles
Authors: Thakurata Debasish Guha , Das Krishna Chandra , Paul Arijita , Dhar Siddhartha Sankar 
Published: March 2022

AbstractToxic organic dyes released into aquatic sources as a result of industrial activities pose a significant threat to the environment. The removal of such dyes from water sources is a challenging task in the context of environmental emergencies. In this present effort, the strontium ferrite nanoparticles were synthesized by coprecipitation followed by a calcination method and is applied for photocatalytic degradation of such organic dyes. The ferrite nanoparticles were characterized by FTIR, XRD, VSM, SEM‐EDX, TEM, and HR‐TEM studies. In the existence of H2O2 under visible light, the catalyst performs efficient degradation of aniline blue (AB) and methyl violet (MV) dyes in a remarkably short interval of time. The superparamagnetic performance of the catalyst was confirmed by VSM, and thus it can be easily recovered from the degraded dye by applying an external magnet. The Fenton mechanism justifies the elevated rate of photo degradation, which generates hydroxyl and perhydroxyl radicals in the progress of the reaction.
Scaling black holes and modularity
Authors: Chattopadhyaya Aradhita , Manschot Jan , Mondal Swapnamay 
Published: March 2022

Abstract
Scaling black holes are solutions of supergravity with multiple black hole singularities, which can be adiabatically connected to a single center black hole solution. We develop techniques to determine partition functions for such scaling black holes, if each constituent carries a non-vanishing magnetic charge corresponding to a D4-brane in string theory, or equivalently M5-brane in M-theory. For three constituents, we demonstrate that the partition function is a mock modular form of depth two, and we determine the appropriate non-holomorphic completion using generalized error functions. From the four-dimensional perspective, the modular parameter is the axion-dilaton, and our results show that S-duality leaves this subset of the spectrum invariant. From the five-dimensional perspective, the modular parameter is the complex structure of a torus T2, and the scaling black holes are dual to states in the dimensional reduction of the M5-brane worldvolume theory to T2. As a case study, we specialize the compactification manifold to a K3 fibration, and explicitly evaluate holomorphic parts of partition functions.
Anxiety and depression in patients with breast cancer undergoing radiotherapy: the role of intelligence, life history, and social support—preliminary results from a monocentric analysis
Authors: Piroth Marc D. , Draia Silvia , Jawad Jehad Abu , Piefke Martina 
Published: March 2022

Abstract
Purpose
It is known that the diagnosis of breast cancer often causes anxiety and depression. Radiotherapy of the breast as an obligatory part of a breast-conserving treatment concept can markedly increase these psychological symptoms in many, but not all patients. In this clinical observational study, we aimed at identifying cognitive, health-related and social factors that may either enhance or reduce the emergence of anxiety and depression.

Methods
Using a longitudinal study design with 25 women (mean age: 52.9 years; SD = 10.6; age range 29–70 years) with a first diagnosis of nonmetastatic breast cancer, measures of anxiety, depression, situational emotional states, intelligence, and aspects of social frameworks were assessed before, during, and after radiotherapy of the breast. At 4 time-points, standard and self-constructed questionnaires were used to assess the course of anxiety and depressive symptoms across the radiotherapy intervention.

Results
We found that anxiety is highest immediately before the start of radiation therapy, while the anxiety level was lowest on the day that therapy was completed. Anxiety and depression were enhanced in women with a lifetime history of chronic diseases at all time points of measurement. Moreover, women with high intelligence and low social support had stronger symptoms of depression than women with low intelligence and a stable family background at some time points of measurement. The degree of anxiety was neither related to intelligence nor to social support.

Conclusion
For the first time, we demonstrate empirical pilot data on cognitive and social modulators of anxiety and depression in women with breast cancer over the course of radiotherapy. Our results may help to optimize clinical procedures and thereby reduce symptoms of anxiety and depression in these patients.
Maturation of beta cells: lessons from in vivo and in vitro models
Authors: Barsby Tom , Otonkoski Timo 
Published: March 2022

AbstractThe ability to maintain normoglycaemia, through glucose-sensitive insulin release, is a key aspect of postnatal beta cell function. However, terminally differentiated beta cell identity does not necessarily imply functional maturity. Beta cell maturation is therefore a continuation of beta cell development, albeit a process that occurs postnatally in mammals. Although many important features have been identified in the study of beta cell maturation, as of yet no unified mechanistic model of beta cell functional maturity exists. Here, we review recent findings about the underlying mechanisms of beta cell functional maturation. These findings include systemic hormonal and nutritional triggers that operate through energy-sensing machinery shifts within beta cells, resulting in primed metabolic states that allow for appropriate glucose trafficking and, ultimately, insulin release. We also draw attention to the expansive synergistic nature of these pathways and emphasise that beta cell maturation is dependent on overlapping regulatory and metabolic networks.
Graphical abstract
Bendamustine plus rituximab in Japanese patients with relapsed or refractory diffuse large B-cell lymphoma
Authors: Murayama Kayoko , Kiguchi Toru , Izutsu Koji , Kameoka Yoshihiro , Hidaka Michihiro , Kato Harumi , Rai Shinya , Kuroda Junya , Ishizawa Kenichi , Ichikawa Satoshi , Ando Kiyoshi , Ogura Michinori , Fukushima Koji , Terui Yasuhito 
Published: March 2022

AbstractThis single-arm phase 3 study was conducted to confirm the results of our phase 2 study of bendamustine (B)-rituximab (R) in patients with relapsed/refractory diffuse large B cell lymphoma (rrDLBCL). The primary endpoint was overall response rate (ORR). Autologous stem cell transplantation-ineligible rrDLBCL patients with ≤ 2 prior chemotherapy regimens received R 375 mg/m2 IV on day 1 and B 120 mg/m2/day IV on days 2 and 3 every 21 days up to 6 cycles. Thirty-eight patients with a median age of 74 years (range, 43–86) received BR. The ORR and complete response rates were 76.3% and 47.4%, respectively. With a median follow-up of 19.5 months including long-term follow-up, median progression-free survival was 11.9 months. Median OS was 29.2 months. Discontinuation of treatment due to Gr3-5 TEAE was observed among 13 of 38 patients (34.2%). One patient with cytomegalovirus enterocolitis died during follow-up. This BR regimen was confirmed to be effective and tolerable in studied patients. ClinicalTrials.gov Identifier: NCT03372837 registered on 14 December 2017, NCT04354402 registered on 21 April, 2020.
Immunoprotection against mixed Eimeria spp. infections in goat kids induced by X-irradiated oocysts
Authors: Barba Emilio , Guedes Aránzazu Carmen , Molina José Manuel , Martín Sergio , Muñoz María Carmen , Ferrer Otilia , Lara Pedro Carlos , Hermosilla Carlos , Taubert Anja , Ruiz Antonio 
Published: March 2022

AbstractStrategies to control goat coccidiosis traditionally rely on the use of management practices combined with anticoccidial treatments, and limited effort has been made, so far, to address immunological control of caprine Eimeria infections. Previously, we showed that monospecific immunization with X-Rad-attenuated Eimeria ninakohlyakimovae oocysts induced considerable immunoprotection upon challenge. In the present study, we conducted a similar vaccination trial but using a mixture of caprine Eimeria species typically present in natural infected goats. For immunization, sporulated oocysts were attenuated by X irradiation (20 kilorad). All infections were performed orally applying 105 sporulated oocysts of mixed Eimeria spp. per animal. In total, 18 goat kids were grouped as follows: (G1) immunized + challenge infected; (G2) primary + challenge infected; (G3) challenge infection control; and (G4) non-immunized/non-infected control. Overall, goat kids infected with attenuated oocysts (= immunized) shed less oocysts in the faeces and showed a lower degree of clinical coccidiosis than animals infected with non-attenuated oocysts. Animals of both challenge groups (G1 and G2) showed partial immunoprotection upon reinfection when compared to challenge infection control (G3). However, the degree of immunoprotection was less pronounced than recently reported for monospecific vaccination against Eimeria ninakohlyakimovae, most probably due to the complexity of the pathogenesis and related immune responses against mixed Eimeria spp. infections. Nevertheless, the data of the present study demonstrate that immunization with attenuated Eimeria spp. oocysts may be worth pursuing as a strategy to control goat coccidiosis.
The implication of holocytochrome c synthase mutation in Korean familial hypoplastic amelogenesis imperfecta
Authors: Choi Hyejin , Lee Kwanghwan , Kim Donghyo , Kim Sanguk , Lee Jae Hoon 
Published: March 2022

Abstract
Objectives
This study aimed to comprehensively characterise genetic variants of amelogenesis imperfecta in a single Korean family through whole-exome sequencing and bioinformatics analysis.

Material and methods
Thirty-one individuals of a Korean family, 9 of whom were affected and 22 unaffected by amelogenesis imperfecta, were enrolled. Whole-exome sequencing was performed on 12 saliva samples, including samples from 8 affected and 4 unaffected individuals. The possible candidate genes associated with the disease were screened by segregation analysis and variant filtering. In silico mutation impact analysis was then performed on the filtered variants based on sequence conservation and protein structure.

Results
Whole-exome sequencing data revealed an X-linked dominant, heterozygous genomic missense mutation in the mitochondrial gene holocytochrome c synthase (HCCS). We also found that HCCS is potentially related to the role of mitochondria in amelogenesis. The HCCS variant was expected to be deleterious in both evolution-based and large population-based analyses. Further, the variant was predicted to have a negative effect on catalytic function of HCCS by in silico analysis of protein structure. In addition, HCCS had significant association with amelogenesis in literature mining analysis.

Conclusions
These findings suggest new evidence for the relationship between amelogenesis and mitochondria function, which could be implicated in the pathogenesis of amelogenesis imperfecta.

Clinical relevance
The discovery of HCCS mutations and a deeper understanding of the pathogenesis of amelogenesis imperfecta could lead to finding solutions for the fundamental treatment of this disease. Furthermore, it enables dental practitioners to establish predictable prosthetic treatment plans at an early stage by early detection of amelogenesis imperfecta through personalised medicine.
Ruppell’s fox movement and spatial behavior are influenced by topography and human activity
Authors: Barocas Adi , Hefner Reuven , Ucko Michal , Shalmon Benny , Leader Noam , Geffen Eli 
Published: March 2022

AbstractGlobal climatic processes have driven an expansion of arid environments, as well as the human populations that depend on these biomes. Human habitation can influence desert ecosystems directly through changes in land use and indirectly through the introduction of alien species that compete with locally adapted fauna. Native species can respond to these processes by spatial or temporal avoidance. Ruppell’s fox is a desert-adapted species inhabiting flat, rocky arid areas that feeds mainly on invertebrates and rodents. We used location data and step selection functions to study the space use of a population in southern Israel. We hypothesized that Ruppell’s fox movement would be influenced by topography due to preference for creeks, where insects and rodents are available, and by human infrastructure as the presence of humans, vehicles and associated animals may induce a fear effect on native species. Ruppell’s fox habitat selection was seasonal. During the dry season, foxes showed preference for flatter areas and creek bottoms and avoided paved roads. During the rainy season, foxes avoided less- trafficked dirt roads. These patterns were likely a consequence of increased territoriality due to denning in the colder season and reduced availability of insects in the dry season. Avoidance of paved and dirt roads may be explained by fear of human presence and perception of risk due to the use of linear features by larger carnivores, such as wolves and red foxes. Our results suggest that current protected, remote and uninhabited areas have an elevated value for the persistence of Ruppell’s fox populations. We recommend limitation of vehicle movement within current reserves and continued monitoring of population trends for this little studied carnivore.
Evaluation of the anterior chamber angle by anterior segment optical coherence tomography after implantable phakic contact lens implantation in myopic eyes
Authors: Mahmoud Mohamed Salah El-Din , Mohamed Asmaa Anwar , Zein Hosny Ahmed 
Published: March 2022

Abstract
Purpose
To evaluate the changes in the angle of the AC and lens vault after IPCL implantation by AS-OCT in myopic patients.

Methods
This was a prospective observational study involving 30 myopic eyes implanted with IPCL. AS-OCT was used to evaluate lens vault and AC angle parameters including anterior chamber angle, angle opening distance and trabecular-iris space area (TISA) at 1, 3 and 6 months postoperatively.

Results
All 3 AC angle parameters were significantly reduced at the 1st postoperative month compared to preoperative values, but remained stable thereafter with no significant change at the 3rd or 6th postoperative months. The lens vault showed no significant change over the entire follow-up period.

Conclusion
IPCL implantation is a safe method for correction of myopia with stable AC angle narrowing over the course of 6 months postoperatively as monitored using AS-OCT.
Dexamethasone-loaded keratin films for ocular surface reconstruction
Authors: Schwab Rebekka , Reichl Stephan 
Published: March 2022

AbstractAmniotic membrane (AM) is often applied as a substitute material during ocular surface reconstruction. However, since AM has several disadvantages, alternative materials must be considered for this application. Keratin films made from human hair (KFs) have previously been presented as a promising option; they exhibited suitable characteristics and satisfactory biocompatibility in an in vivo rabbit model. Nevertheless, dexamethasone (DEX) eye drops are necessary after surgery to suppress inflammation. Since eye drops must be administered frequently, this might result in poor patient compliance, and the release of DEX at the transplant site would be clinically beneficial. Therefore, we aimed to incorporate DEX into KFs without hindering the positive film characteristics. Drug-loaded KFs were generated either by suspension technique or by the addition of solubilizing agents. The resulting specimens were analyzed regarding appearance, loading capacity, transparency, mechanical characteristics, swelling behavior and in vitro release. Furthermore, biocompatibility was assessed in vitro by determining the cell viability, seeding efficiency and growth behavior of corneal epithelial cells. The amount of incorporated DEX influenced the transparency and biomechanical properties of the films, but even highly loaded films showed properties similar to those of AM. The suspension technique was identified as the best incorporation approach regarding chemical stability and prolonged DEX release. Moreover, suspended DEX in the films did not negatively impact cell seeding efficiencies, and the cell-growth behaviors on the specimens with moderate DEX loads were satisfactory. This suggest that these films could comprise a suitable alternative material with additional anti-inflammatory activity for ocular surface reconstruction.
The Relevance of Religion for Political Office: Voter Bias Toward Candidates from Different Religious Backgrounds
Authors: Madrid Raul , Merolla Jennifer L. , Yanez Ruiz Aldo , Schroedel Jean Reith 
Published: March 2022

AbstractOver the last several decades, Gallup data shows an increased willingness among members of the public to support presidential candidates from a wide range of religious backgrounds, though a nontrivial proportion of the public is still unwilling to vote for an Atheist, Mormon, or Muslim. What underlies this opposition? We argue that voters evaluate candidates from religious out-groups more negatively on a wide range of dimensions considered desirable for political office, and that this bias should be more pronounced among the highly religious. We show support for these arguments using a survey experiment fielded with YouGov. Atheists and Muslim candidates were perceived more negatively on a large set of traits considered desirable for political office compared to candidates from religious in-groups, and Mormon candidates fall somewhere in between. The Atheist and Muslim candidates were also perceived as less competent on a diverse set of issues.
Promoting a set-oriented way of thinking in a U.S. High School discrete mathematics class: a case study
Authors: Soto Osvaldo , Siy Kris , Harel Guershon 
Published: March 2022

AbstractIn this case study, we investigate one teacher’s implementation of DNR-based combinatorics curriculum in their high school discrete mathematics class. By examining the teacher’s practices in whole-class discussions of two counting problems, we study how they advanced a variety of ways of thinking to support the development of a set-oriented way of thinking about counting. In particular, we find the teacher worked to build shared experience and understanding of mathematical ideas by grounding her teaching in students’ ways of understanding and leveraging students’ intellectual needs. In doing so, the teacher promoted a set-oriented way of thinking through attending to connections between sets of outcomes, counting processes, and formulas in student representations and justifications; elevated solutions employing process pattern generalization; and advanced the beliefs that counting problems can be solved in many ways and entail several types of mathematical activity.
Evaluation of Ylang Ylang essential oil on alcohol induced hepatotoxicity in rats
Authors: Tubachi Siddarth Sunil , Rasal V. P. , Ugare Sanjay R. , Khatib Nayeem A. , Ojha Prachi Sanjeev , Patil Vishal S. 
Published: March 2022

AbstractThe present study is aimed to evaluate the effect of ylang ylang essential oil in alcohol induced hepatotoxicity in rats. Alcohol was used as an inducing agent and Silymarin as a standard molecule. Body weight was measured at a 3 days interval till the twenty first day and at the end of the study, serum AST, ALT, TP, TC, TG, and TB biomarkers were estimated. Further, the liver tissue was evaluated for antioxidant enzymes namely CAT, LPO, SOD and GSH level. Liver weight and histopathology was accessed at the end. Phytocompounds were shortlisted from literature and curated databases. Probable targets of each compound were identified using the SwissTargetPrediction web server. Probable mechanisms of phytocompounds against Alcohol induced hepatotoxicity were analyzed by the STRING and KEGG pathway database. The network between compounds, targets, and pathways was generated via Cytoscape ver. 3.6.1. Docking was performed by AutoDock vina using PyRx0.8v. YYEO group showed increased BW compared to alcohol group and also reversed the increased serum AST, ALT, TP, TC, TG, and TB biomarkers and also increased the level of antioxidant enzymes compared to alcohol induced group. YYEO 400 mg/kg exhibited normal liver weight and histology compared to alcohol. Enrichment and network analysis identified YYEO 63 compounds as beneficial modulators of protein molecules associated with hepatotoxicity via modulating Toll-like receptor, Adipocytokine, TNF, Sphingolipid, FoxO, AMPK, Relaxin, MAPK, NF-kappa B, HIF-1, Fc epsilon RI, IL-17, VEGF, T cell receptor, NOD-like receptor, mTOR, PI3K- Akt signaling pathway, etc. Canangaterpene 1 was identified as a potent inhibitor of aldose reductase.
Graphical abstract
United Kingdom Patent Decisions 2021
Authors: Trigg Robyn 
Published: March 2022

AbstractThis report highlights a selection of the most important UK patent decisions from 2021, including: one Supreme Court judgment concerning the economic tort of unlawful means, which importantly maintained the status quo for litigating patents in the UK; four Court of Appeal judgments (one concerning sufficiency and functional claiming, which overturned the decision below; two where the first instance finding was upheld; and one considering the crown use exception); and, seven High Court judgments (one giving obiter guidance on the Formstein defence in cases of infringement by equivalents; four relating to applications for expedition of proceedings; and two relating to FRAND and the effect of the ETSI undertaking).