bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple miliary osteoma cutis, renal failure and secondary hyperparathyroidism in a geriatric patient
Authors: Brooks John K. , Jang Hokyoung , Harrow Arthur S. , Price Jeffery B. 
Published: May 2022

AbstractIntroductionMiliary osteoma cutis (MOC) is a cutaneous disorder that develops in response to an ill‐defined process or following acne vulgaris. Most cases present incidentally as small radiographic aggregations of normal bone within the cheeks. Infrequently, MOC has been reported with systemic disease, including renal failure.Case presentationAn 82‐year‐old man presented with renal failure and secondary hyperparathyroidism. Intraoral radiographs displayed bilateral radiopacities. This is the first documented case of MOC synchronous with renal failure and secondary hyperparathyroidism in a geriatric patient.ConclusionsPatients with MOC and manifestations associated with nephropathy should undergo a comprehensive medical work‐up and laboratory studies. Timely recognition of incidental radiographic findings may improve clinical outcomes.
Arabic and Sindhi manuscript collections in Sindh, Pakistan: Resources and perspectives from the Indian Ocean
Authors: Baig Sohaib 
Published: May 2022

AbstractThis article presents an introduction to an array of historical sources from Sindh (in modern‐day Pakistan) in the Arabic and Sindhi languages. It highlights the sizeable number of Arabic manuscripts in Sindhi institutions and discusses some of the larger historical forces that shaped their collection in the colonial and pre‐colonial periods. In addition, it reflects on the significance these sources may hold for the field of Indian Ocean history, especially in terms of legal and intellectual history. Finally, this article lists and discusses bibliographical resources and catalogs that researchers can use to navigate major libraries and archival institutions across Karachi, Jamshoro, and interior Sindh.
Comparative study of Rb1, cyclin D1 and p16 immunohistochemistry expression to distinguish lung small‐cell carcinoma and large‐cell neuroendocrine carcinoma
Authors: Papaxoinis G , Bille A , McLean E , Nonaka D 
Published: May 2022

AimsLarge‐cell neuroendocrine carcinoma (LCNEC) and small‐cell carcinoma (SCLC) of lung encompass high‐grade neuroendocrine tumour category and share several fundamental features. As both tumours may respond to different treatment modalities and show unique molecular alterations distinction between the two is clinically relevant, but can be challenging due to sampling and fixation issues and shared morphological features.MethodsSurgically resected primary SCLC (n = 129) and LCNEC (n = 27) were immunohistochemically stained with Rb1, cyclin D1 and p16 using tissue microarray (TMA), and expression patterns of the proteins were compared between the two to identify the discriminatory pattern.ResultsAll markers had high diagnostic accuracy; Rb1 was the highest followed by p16 and cyclin D1. The majority of SCLC had the pattern Rb1−/p16+/cyclin D1– and more than half of LCNEC had Rb1+/p16−/cyclin D1+. Overall, the expression pattern Rb1– and cyclin D1– was strongly associated with the diagnosis of SCLC, while the pattern Rb1+ and/or cyclin D1+ was strongly associated with LCNEC. The use of this simplified expression pattern leads to a diagnostic accuracy of 97.3%. p16 did not add to further discrimination. The heterogeneity in Rb1, cyclin D1 and p16 expression was insignificant in SCLCs compared with LCNECs.ConclusionsUse of Rb1, cyclin D1 and p16 immunohistochemistry can distinguish the two with high accuracy. Notably, the Rb1−/cyclin D1– pattern in given tumour sample would confirm the diagnosis of SCLC. Our results could be extrapolated and applied to routine diagnostic samples such as biopsies and cytology samples.
Enzyme replacement therapy leading to improvement in myeloma indices in a patient with concomitant Gaucher disease
Authors: Harel Reut , Gavish Israel , Aviv Ariel , Greenman Maravi Nofar , Trougouboff Philippe , Zimran Ari , Revel‐Vilk Shoshana 
Published: May 2022

AbstractPatients with Gaucher disease (GD) have been shown previously to carry an increased risk for cancer, most commonly multiple myeloma (MM). It is currently unknown whether treatment for GD has an effect on the prevention or amelioration of MM. We present the case of a 41‐year‐old patient simultaneously diagnosed with GD and smouldering MM. Enzyme replacement therapy with Velaglucerase‐alfa significantly improved myeloma indices.
HbA1c, blood pressure, and cholesterol control in adults with diabetes: A report card for Kuwait
Authors: Alkandari Abdullah , Gujral Unjali P , Bennakhi Abdullah , Qabazard Sarah , Al‐Wotayan Rihab , Al Duwairi Qais , Al‐Kandari Hessa , Narayan KM Venkat , Alarouj Monira 
Published: May 2022

ABSTRACTAimTo assess the level of glycemic, blood pressure, and cholesterol control (the ‘ABCs’) nationally amongst adults with diabetes living in Kuwait.Materials and MethodsUsing data from two national cross‐sectional surveys, the levels of risk factor control were assessed in 1,801 adults with diabetes, aged 18–82 years. Glycemic control was defined as HbA1c < 7%, blood pressure control as systolic and diastolic blood pressures of <140/90 mmHg, and non‐HDL cholesterol control as <3.4 mmol/L.ResultsThe percentage of adults with diabetes achieving control was 39.2% (95% CI, 37.0–41.5) for glycemia, 58.4% (95% CI, 56.0–60.7) for blood pressure, and 28.3% (95% CI, 26.3–30.4) for non‐HDL cholesterol. The percentage of adults who were non‐smokers was 77.6% (95%, CI 75.6–79.4). The percentage of adults with diabetes achieving control on all three risk factors was 7.4% (95% CI, 6.3–8.8), and only 5.8% (95% CI, 4.8–7.0) achieved ABC control and were nonsmokers. ABC control was 30% higher in women compared with men. Non‐Kuwaitis were almost twice as likely to have uncontrolled ABC factors compared with Kuwaitis.ConclusionsOnly 1 in 13 people with diabetes in Kuwait achieved good control of glycemia, blood pressure, and cholesterol. Only 2 in 5 achieved glycemic control, 6 in 10 blood pressure control, and 2 in 7 cholesterol control. A national diabetes quality improvement program is urgently needed to improve the quality of care and to prevent long‐term complications.
Spatial assessment of potential areas at risk from blueberry gall midge distribution in South Korea
Authors: Byeon Dae‐hyeon , Lee Wang‐Hee 
Published: May 2022

AbstractDasineura oxycoccana, the blueberry gall midge, has damaged domestic blueberry cultivation since its presence was confirmed in Korea. In this study, the domestic climatic suitability of D. oxycoccana was evaluated using the CLIMEX model, which comprehensively integrates the species biology and regional climate. In addition, we derived the risk posed to major areas of blueberry cultivation by considering the domestic potential distribution of D. oxycoccana based on climatic suitability D. oxycoccana showed the highest occurrence suitability on the southern coast under the current climate, and its population is expected to gradually increase inland due to climate change. Jeju and the southern coast were the major areas that were presently found to be at risk from D. oxycoccana; the area at risk from D. oxycoccana is expected to extend to southern Gyeonggi‐do and Ganwon‐do by 2040 and 2060, respectively. D. oxycoccana was predicted to occur throughout the country according to climate change, suggesting increase in its infestation in blueberry cultivation. Therefore, we expected this study provides precautionary evaluation for monitoring and controlling the pest.
Molecular cloning, characterization and expression analysis of CXCR3a and CXCR3b from Nile tilapia (Oreochromis niloticus)
Authors: Gao Along , Wu Liting , Li Lan , Han Biao , Ye Jianmin 
Published: May 2022

AbstractThe CXC chemokine receptors (CXCRs) are members of the seven transmembrane (7‐TM) G‐protein‐coupled receptor superfamily that involves innate and adaptive immune systems. In this study, CXCR3a and CXCR3b from Nile tilapia (Oreochromis niloticus) were cloned and identified, designated as OnCXCR3a and OnCXCR3b. The open reading frames of OnCXCR3a and OnCXCR3b were 1074 and 1080 bp, encoding the predicted proteins of 357 and 359 amino acids, respectively. Multiple alignment analysis of OnCXCR3a‐ and OnCXCR3b‐deduced protein sequences with the mammalian and bird sequences indicated the presence of typical structural features of chemokine receptors, including a 7‐TM domain and conserved motifs. Quantitative real‐time PCR analysis revealed that OnCXCR3a and OnCXCR3b were constitutively expressed in a wide range of tissues. When stimulated with Streptococcus agalactiae, Aeromonas hydrophila, polyinosinic:polycytidylic acid and lipopolysaccharide in vivo or in vitro on leukocytes, the mRNA levels of OnCXCR3a and OnCXCR3b were significantly upregulated. Overall, these results indicated that OnCXCR3s might be involved in host immune responses in Nile tilapia.
Transcriptome analysis of turbot (Scophthalmus maximus) head kidney and liver reveals immune mechanism in response to Vibrio anguillarum infection
Authors: Song Yuting , Dong Xianzhi , Hu Guobin 
Published: May 2022

AbstractThe diseases triggered by Vibrio anguillarum infection have created huge economic losses to the turbot (Scophthalmus maximus) farming industry. However, the immune mechanism of turbot to V. anguillarum infection has not been deeply investigated. To better understand the immune response of turbot to V. anguillarum infection, transcriptome analysis of the head kidney and liver of turbot was performed. A total of 15,948 and 11,494 differentially expressed genes (DEGs) were obtained from the turbot head kidney and liver, respectively. Transcriptome analysis revealed that the head kidney and liver of turbot have some differences in the gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the DEGs for the different functions of these two organs. Although there are many uncertain factors in this immune process, such as the occurrence of alternative splicing (AS) events and the differences in the protein structure of the DEGs, the NFκB signalling pathway, MKK‐dependent AP‐1 activation, JAK‐STAT signalling pathway, the signal transmission of MHC Ⅰ and a series of DEGs including HSP90 driving NLRP3 to produce inflammatory factors (IL‐1β, IL‐8, TNFα, etc.) were possible important immune response pathways for turbot to V. anguillarum infection. Overall, our research has conducted a preliminary exploration of the immune mechanism of turbot in response to V. anguillarum infection.
Raf kinase inhibitory protein reduces bradykinin receptor desensitization
Authors: Chivers Samuel B. , Brackley Allison Doyle , Jeske Nathaniel A. 
Published: May 2022

AbstractInflammatory hyperalgesia represents a nociceptive phenotype that can become persistent in nature through dynamic protein modifications. However, a large gap in knowledge exists concerning how the integration of intracellular signaling molecules coordinates a persistent inflammatory phenotype. Herein, we demonstrate that Raf Kinase Anchoring Protein (RKIP) interrupts a vital canonical desensitization pathway to maintain bradykinin (BK) receptor activation in primary afferent neurons. Biochemical analyses of primary neuronal cultures indicate bradykinin‐stimulated PKC phosphorylation of RKIP at Ser153. Furthermore, BK exposure increases G‐protein Receptor Kinase 2 (GRK2) binding to RKIP, inhibiting pharmacological desensitization of the BK receptor. Additional studies found that molecular RKIP down‐regulation increases BK receptor desensitization in real‐time imaging of primary afferent neurons, identifying a key pathway integrator in the desensitization process that controls multiple GRK2‐sensitive G‐protein coupled receptors. Therefore, RKIP serves as an integral scaffolding protein that inhibits BK receptor desensitization.
image
Psychosocial factors in patients with kidney failure and role for social worker: A secondary data audit
Authors: Hansen Micaella Sotera , Tesfaye Wubshet , Sud Kamal , Sewlal Beena , Mehta Bharati , Kairaitis Lukas , Tarafdar Surjit , Chau Katrina , Razi Zaidi Syed Tabish , Castelino Ronald 
Published: May 2022

AbstractBackgroundPeople with kidney failure face a multitude of psychosocial stressors that affect disease trajectory and health outcomes.ObjectivesTo investigate psychosocial factors affecting people with kidney failure before or at start of kidney replacement therapy (KRT) and kidney supportive and palliative care (KSPC) phases of illness and to explore role of social worker during the illness trajectory.MethodsWe conducted a secondary data audit of patients either before or at start of KRT (Phase 1) and at the KSPC (Phase 2) of illness and had psychosocial assessments between March 2012 and March 2020 in an Australian setting.ResultsSeventy‐nine individuals, aged 70 ± 12 years, had at least two psychosocial assessments, one in each of the two phases of illness. The median time between social worker evaluations in Phase 1 and Phase 2 was 522 (116−943) days. Adjustment to illness and treatment (90%) was the most prevalent psychosocial issue identified in Phase 1, which declined to 39% in Phase 2. Need for aged care assistance (7.6%−63%; p < 0.001) and carer support (7.6%−42%; p < 0.001) increased significantly from Phase 1 to Phase 2. There was a significant increase in psychosocial interventions by the social worker in Phase 2, including supportive counselling (53%−73%; p < 0.05), provision of education and information (43%−65%; p < 0.01), and referrals (28%−62%; p < 0.01).ConclusionAdults nearing or at the start of KRT experience immense psychosocial burden and adaptive demands that recognisably change during the course of illness. The positive role played by the nephrology social worker warrants further investigation.
Change time: Timing and placing late Romanticism
Authors: de Groote Brecht 
Published: May 2022

AbstractActing on recently surging critical interest in late Romanticism, a subperiod taken to range roughly from the later 1810s through the 1840s, the present article reviews past and current work in this burgeoning field, particularly highlighting developing avenues for future research. Two competing accounts of late Romanticism are contrasted: a long‐dominant take which regards the subperiod as fundamentally secondary, derived, and inferior; and a recently energised perspective which reveals the vibrancy and innovativeness of late‐Romantic culture. If the former construes history by prioritising the experiences of poets, acting on a cultural paradigm that pivots on the centrality of a particularised genre, the latter pursues a Romanticism that is reconfigured under the pressure of a developing media system, in which multiple specialised genres acquire distinct functions. The discussion of these two perspectives is anchored in the late‐Romantic fascination for times and places; that is, in debates pertaining to periodicity and eventfulness, and to nationalism and transnationalism.
A systematic review of the relationship between momentary emotional states and nonsuicidal self‐injurious thoughts and behaviours
Authors: Brown Alexandra C. , Dhingra Katie , Brown Terence D. , Danquah Adam N. , Taylor Peter James 
Published: May 2022

AbstractBackgroundNonsuicidal self‐injury (NSSI) is associated with high levels of distress, co‐morbid mental health issues, and elevated risk of suicide. Previous literature indicates that emotion regulation is the most endorsed function of NSSI. Experience Sampling Methodology (ESM) provides a powerful tool for investigating the moment‐to‐moment associations between emotional states and NSSI thoughts and behaviours. The aim of the current study was to systematically review and evaluate ESM research concerning the relationship between momentary emotional states and NSSI.MethodsA systematic search of electronic databases from date of inception to 16th April 2021 was conducted. This was supplemented through backwards citation tracking. A risk of bias assessment was completed prior to data synthesis.ResultsNineteen eligible studies were identified for inclusion in the review. Heightened negative affect was found to typically precede instances of NSSIT thoughts and behaviour. Results were less consistent for positive affect.LimitationsSample sizes across studies were often small, meaningful effect sizes were not always reported, and non‐validated measures of NSSI thoughts and behaviour were used during ESM assessments.ConclusionsThe results support affect regulation models of NSSI, and demonstrate the value of ESM studies, specifically those sampling more than once per day, in plotting the temporal, “in‐the‐moment” characteristics of these processes.
Bi‐directional, long‐distance hormonal signalling between roots and shoots of soil water availability
Authors: Huntenburg Katharina , Puértolas Jaime , de Ollas Carlos , Dodd Ian C. 
Published: May 2022

AbstractWhile the importance of plant water relations in determining crop response to soil water availability is difficult to over‐emphasise, under many circumstances, plants maintain their leaf water status as the soil dries yet shoot gas exchange and growth is restricted. Such observations lead to development of a paradigm that root‐to‐shoot signals regulate shoot physiology, and a conceptual framework to test the importance of different signals such as plant hormones in these physiological processes. Nevertheless, shoot‐to‐root (hormonal) signalling also plays an important role in regulating root growth and function and may dominate when larger quantities of a hormone are produced in the shoots than the roots. Here, we review the evidence for acropetal and basipetal transport of three different plant hormones (abscisic acid, jasmonates, strigolactones) that have antitranspirant effects, to indicate the origin and action of these signalling systems. The physiological importance of each transport pathway likely depends on the specific environmental conditions the plant is exposed to, specifically whether the roots or shoots are the first to lose turgor when exposed to drying soil or elevated atmospheric demand, respectively. All three hormones can interact to influence each other's synthesis, degradation and intracellular signalling to augment or attenuate their physiological impacts, highlighting the complexity of unravelling these signalling systems. Nevertheless, such complexity suggests crop improvement opportunities to select for allelic variation in the genes affecting hormonal regulation, and (in selected crops) to augment root–shoot communication by judicious selection of rootstock–scion combinations to ameliorate abiotic stresses.
Dental treatment of patients with prune belly syndrome
Authors: Quilici Garrett , Tolarova Marie M. , Quilici Mary , Quilici Diana L. 
Published: May 2022

AbstractBackgroundPrune belly syndrome (PBS), also known as Eagle‐Barrett syndrome (EGBRS), is a rare congenital disease characterized by deficiency or absence of abdominal wall muscles, urological abnormalities, and bilateral cryptorchidism.Types of Studies ReviewedA review of literature was done using four search engines (PubMed, Google Scholar, Scopus, Science Direct) and keywords (individually and in combinations): prune belly syndrome, PBS, Eagle‐Barrett syndrome, dental manifestation, clinical manifestation, and psychological aspects. The search was run with no language restrictions and covered the 1965–2021 time period.ResultsThe search yielded a large number of articles. The vast majority were dealing with a variety of treatments. PBS is a multisystem disease with a variable spectrum ranging from mild cases to infant mortality. Comorbidities of PBS (63% gastrointestinal, 65% orthopedic, and 49% cardiopulmonary) present challenges for treatment. PBS affects quality of life of patients and caregivers. We selected and summarized published information that is relevant to oral health and dental care.Conclusions and Practical ImplicationsProviding information to dental practitioners will improve their understanding of PBS. It will help them to better treat patients with PBS and it will encourage more dental providers to welcome patients with PBS into their dental clinics.
Description of non‐brachycephalic canine conjunctival microbiome before and after application of an antiseptic preparation
Authors: Seyer Lindsay D. , Wills Robert , Scott Erin M. , Betbeze Caroline 
Published: May 2022

AbstractObjectiveTo evaluate canine conjunctival microbiome before and after an antiseptic preparation using aerobic culture and DNA sequencing.Animals StudiedSix healthy non‐brachycephalic dogs.ProceduresDogs randomly received povidone‐iodine 1:50 dilution solution in one eye with the second eye serving as a control. Standardized volumes of solution, number of sterile cotton tipped applicators, and preparation times of 5 min were used. Aerobic culture and DNA sequencing samples were collected from inferior conjunctival fornices at baseline, immediately following, 24 h, and 4 weeks following antiseptic preparation. Aerobic culture data were evaluated using paired t‐test and linear regression. Illumina platform was used to sequence bacterial DNA using primers to target the V4 region of bacterial 16S rRNA. Quantitative Insights Into Molecular Ecology (QIIME 2.0) was used to analyze data.ResultsBaseline aerobic cultures consisted of Bacillus (35%), Staphylococcus (30%), Streptococcus (20%), Moraxella (5%), Micrococcus (5%), and Simonsiella spp. (5%). No significant difference was detected in mean number of species cultured at baseline and following treatment (p = .465). Treatment, sample time, or interaction was not significant (p > .393). The most abundant phyla at baseline via DNA sequencing were Proteobacteria (57.04%), Actinobacteria (19.89%), Firmicutes (3.25%), and Bacteroidetes (5.5%). Alpha and beta diversity matrices at baseline and over time revealed no significant change in species richness or bacterial composition. Relative abundance of bacterial taxa did not significantly differ in treated or control eyes over time.ConclusionsConjunctival bacterial flora identified differed between culture dependent and independent methods. The bacterial community remained stable over time after application of the antiseptic preparation.
Possible bidirectional human–swine and subsequent human–human transmission of influenza virus A(H1N1)/2009 in Japan
Authors: Kuroda Moegi , Usui Tatsufumi , Shibata Chiharu , Nishigaki Haruka , Yamaguchi Tsuyoshi 
Published: May 2022

AbstractIn 2019, sows at a swine farm in Japan showed influenza‐like illness (ILI) shortly after contact with an employee that exhibited ILI. Subsequently, a veterinarian became sick shortly after examining the sows and was diagnosed with influenza A virus (IAV) infection. Then, her family also contracted the infection. Subsequently, Pandemic A(H1N1)2009 viruses were isolated from all samples obtained from the sows, veterinarian and her family. Whole‐genome analysis of the isolates confirmed that the viruses belonged to the same lineage (6B.1A) and the genome sequences obtained from all of the isolates were almost identical to each other. Furthermore, an epidemiological survey revealed no contact between veterinarians or their families and influenza patients prior to the onset of illness. These results strongly indicated a case of bidirectional infection between humans and sows. At the same time, we found a few unique mutations in the IAV genomes corresponding to the host species. The mutations that occurred in the virus after it was transferred from the farm worker to the sows were not observed in the humans infected from the sows, probably as a result of the mutations reverting to the original nucleotides. These results demonstrate that the bidirectional transmission of IAV is a potential risk for the next pandemic outbreak due to the emergence of new mutant strains.