bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical phenotypes and prognosis of cytomegalovirus infection in the pediatric systemic lupus erythematosus: a longitudinal analysis
Authors: Zhang Tianyu , Yu Zhongxun , Gao Sihao , Zhang Yuelun , Wang Changyan , Jian Shan , Wang Lin , Gou Lijuan , Li Ji , Ma Mingsheng , Song Hongmei 
Published: December 2022

Abstract
Background: Cytomegalovirus (CMV) plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). However, it is not clear whether the anti-CMV treatment has an impact on the prognosis of SLE patients with CMV infection. We aimed to analyze the clinical characteristics and prognosis of CMV infection in pediatric SLE (pSLE) and to evaluate the effect of anti-CMV treatment on pSLE outcome.
Methods: A retrospective study including 146 pSLEfrom 2012 to 2021 was conducted. CMV-positive and CMV-negative groupswere compared by univariate analysis and stepwise logistic multiple regression to analyze the clinical characteristics of CMV infection in pSLE. Generalized estimating equations (GEE) were used to model the longitudinal dynamics of pSLE disease activity with or without CMV infection and anti-CMV treatment.
Results: The CMV infection rate was 74.7% (109/146) in this pSLE cohort. CMV-positive pSLE patients were more likely to present positive anti-dsDNA antibody, hypocomplementemia, high SLEDAI-2K score and musculoskeletal involvement (P < 0.05). Survival analysis showed that CMV-positive pSLE patients were more prone to disease flare and poorer outcomes. GEE modeling indicated that CMV phosphoprotein 65 (pp65) titers were positively correlated with SLEDAI-2K, and anti-CMV treatment could better reduce pSLE activity than non-treatment (P < 0.05).
Conclusions: CMV infection is highly prevalent among pSLE patients. Positive anti-dsDNA antibody, hypocomplementemia, high SLEDAI-2K score and musculoskeletal involvement were significant clinical clues indicating CMV infections in pSLE. CMV infection is correlated with higher disease activity and poorer outcome. Anti-CMV treatment can reduce disease activity and flares.
Role of Authentication Factors in Fin-Tech Mobile Transaction Security
Authors: Khan Habib Ullah , Sohail Muhammad , Nazir Shah , Hussain Tariq , Shah Babar , Ali Farman 
Published: December 2022

Abstract
Fin-Tech is the merging of finance and technology to be considered a key term for technology-based financial operations and money transactions as far as Fin-Tech is concerned. In the massive field of business, mobile money transaction security is a great challenge for researchers. The user authentication schemes restrict the ability to enforce the authentication before the account can access and operate. Although authentication factors provide greater security than a simple static password, financial transactions have potential drawbacks because cybercrime expands the opportunities for fraudsters. The most common enterprise challenge is mobile-based user authentication during transactions, which addresses the security issues against fraudsters. The confirmation of a user legitimation before the money transaction is highlighted by mechanisms and technologies from previous studies that may be helpful in user authentication. Internet of Things (IoT) technologies may have potential vulnerabilities for hackers to hack the user credential information for illegal use. This study aims to identify the technologies for user authentication and the opportunity for their transformation to mobile money transaction security despite having all the legally required data for a transaction. This proposed review has identified the role of multifactor authentication techniques for authentication to mitigate the risk of fraudulent transactions. The analysis through 92 articles taken from famous publishers. The most relevant articles address authentication problems, of which 54 percent describe money transaction security, and the rest of the articles highlight the supporting technology for user authentication. The study platform described the technology-based approaches with the appreciation of new ideas for secure money transactions. Multifactor authentication might be a key term in advanced security to ensure the user is legitimate by using advanced technology and algorithms to predict and find transaction risks and discourage fraudsters from trying.
Evaluating the sustainability of lightweight drones for delivery: towards a suitable methodology for assessment
Authors: Mitchell Sinéad , Steinbach Juliana , Flanagan Tomas , Ghabezi Pouyan , Harrison Noel , O'Reilly Simon , Killian Stephen , Finnegan William 
Published: December 2022

Abstract
Drone technology is widely available and is rapidly becoming a crucial instrument in the functions of businesses and government agencies worldwide. The demand for delivery services is accelerating particularly since the Covid-19 pandemic. Both companies and customers want these services to be efficient, timely, safe, and sustainable, but these are major challenges. Last-mile delivery by lightweight short-range drones has the potential to address these challenges. However, there is a lack of consistency and transparency in assessing and reporting the sustainability of last-mile delivery services and drones. This paper critically reviews published assessments (specifically lifecycle assessment and circularity). The study reveals a lack of comprehensive studies, and a need to examine composite and battery manufacturing developments and provides key considerations for future study development.
Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: A cross-sectional case-control study in the era of biologic drug therapies
Authors: Räsänen Kati , Markula-Patjas Kati , Kantanen Saija , Sipilä Kalle , Lakka Timo , Arikoski Pekka , Piippo-Savolainen Eija 
Published: December 2022

Abstract
Background: In recent years, biologic drug therapies have altered the course of juvenile idiopathic arthritis (JIA) possibly also improving the patients’ physical fitness. However, studies measuring both cardiorespiratory and muscular fitness in children with JIA are sparse and have failed to show consistent results.
Our aim was to assess both cardiorespiratory and neuromuscular fitness and contributing factors in children and adolescents with JIA in the era of biologic drug therapies.
Methods: This cross-sectional study consisted of 73 JIA patients (25 boys, 48 girls) aged 6.8- 17.5 years and 73 healthy age- and sex-matched controls, investigated in 2017-2019. Cardiorespiratory fitness was assessed by maximal ergospirometry and neuromuscular fitness by speed, agility, balance, and muscle strength tests.
Results: Means (± SD) of maximal workload (Wmax/kg) and peak oxygen uptake (VO2peak/kg,) were lower in JIA patients than in controls (Wmax/kg: 2.80 ± 0.54 vs. 3.14 ± 0.50 Watts, p<0.01; VO2peak/kg: 38.7 ± 7.53 vs. 45.8 ± 6.59 ml/min/kg, p<0.01). Shuttle-run, sit-up and standing long jump test results were lower in JIA patients than in controls (p<0.01). Mean (±SD) daily activity was lower (89.0 ± 44.7 vs. 112.7 ± 62.1 min/day, p<0.05), and sedentary time was higher (427 ± 213 vs. 343 ± 211 min/day, p<0.05) in JIA patients compared to controls. Physical activity and cardiorespiratory or neuromuscular fitness were not associated with disease activity.
Conclusions: Regardless of disease activity, JIA patients were physically less active and had lower cardiorespiratory and neuromuscular fitness than their same aged controls with no JIA. Therefore, JIA patients should be encouraged to engage in physical activities as a part of their multidisciplinary treatment protocols to prevent adverse health risks of low physical activity and fitness.
Trial registration: Not applicable.
Wastewater-based epidemiology predicts COVID-19-induced hospital and ICU admission numbers in over 100 USA counties
Authors: Li Xuan , Liu Huan , Gao Li , Sherchan Samendra , Zhou Ting , Khan Stuart , Loosdrecht Mark van , Wang Qiin 
Published: December 2022

Abstract
With the ease of coronavirus disease (COVID-19) emergency status globally, a population-wide low-cost prediction for COVID-19-induced hospitalization and intensive care unit (ICU) admission numbers is essential for healthcare systems. For the first time, we evaluated the feasibility of using wastewater-based epidemiology (WBE) to predict COVID-19-induced hospitalization and ICU admission numbers in 102 counties across 42 states in the United States of America (USA), covering a population of nearly 60 million, through random forest models using the county-level weekly wastewater surveillance data (over 15 months). WBE-based models accurately predicted the admission numbers, allowing a preparation window of 5-28 days. In real applications, periodically updated WBE-based models showed good accuracy and transferability, with mean absolute error within 20 and 2 patients/100k population for upcoming hospitalization and ICU admission numbers in 28 days, respectively. Our study demonstrated the potential of using WBE as a cost-effective method to provide early warnings for healthcare systems.
MOPSO process parameters optimization in ultrasonic vibration-assisted grinding of hardened steel
Authors: Huang Qiang , Zhao Biao , Qiu Yutong , Cao Yang , Fu Yucan , Chen Qingliang , Tang Menglan , Deng Mingming , Liu Guoliang , Ding Wenfeng 
Published: December 2022

Abstract
Ultrasonic vibration-assisted grinding (UVAG) is frequently prescribed as an effective technique to improve the grindability of difficult-to-cut materials, earning tremendous application opportunities in the industrial field. However, the traditional optimization of grinding parameters requires substantial experimental analyses and is prone to fall into a local optimum. In this study, a multiobjective particle swarm optimization (MOPSO) model for grinding forces and surface roughness is established on the basis of comparative experiments between UVAG and conventional grinding. Optimized process parameters are then used to conduct ultrasonic vibration-assisted profile grinding experiments. Results show that the tangential and normal grinding forces are reduced by 20.51% and 18.91%, respectively, and the ground surface roughness (Ra) is decreased by 9.47%. In addition, the sharpness of grinding wheels can be maintained for UVAG. A Pareto solution set with 15 noninferior solutions is obtained using the MOPSO algorithm, suggesting that the good surface roughness is realized using larger wheel speed and cutting depth and a smaller feed speed. Finally, forming workpieces with excellent shape accuracy and high surface quality, as well as optimized machining parameters, are achieved under the ultrasonic vibration-assisted profile grinding process.
Clinical value of using heart rate variability biofeedback before elective CT coronary angiography to reduce heart rate and the need for beta-blockers
Authors: Langguth Patrick , Wolf Carmen , Sedaghat Sam , Frank Johanne , Both Marcus , Jansen Olav , Ravesh Mona Salehi , Lebenatus Annett 
Published: December 2022

Abstract
Objectives: The value of biofeedback before elective coronary computed tomography angiography (CCTA) to reduce patients’ heart rates (HR) was investigated in the current work.
Methods: 60 patients who received CCTA to exclude coronary artery disease were included in our study and separated into two groups: with biofeedback (W-BF) and without biofeedback (WO-BF). The W-BF group used a biofeedback device for 15 min before CCTA. HR was determined in each patient at five measurement time points (MTP): during the pre-examination interview (MTP1), positioning on the CT patient table (MTP2), immediately before CCTA (MTP3), CCTA image acquisition (MTP4), and after completing CCTA (MTP5). If necessary, beta-blockers were administered in both groups after MTP3 until a HR of less than 65 bpm was achieved. Two board-certified radiologists subsequently assessed the image quality and analyzed the findings.
Results: Overall, the need for beta-blockers was significantly lower in patients in W-BF group than in WO-BF group (p=0.032). In patients with a HR of 81-90, beta-blockers were not required in 4 of 6 cases in the W-BF group, whereas in the WO-BF group all patients needed beta-blockers (p=0.03). We found a significant decrease in HR between MTP1 and MTP2 in W-BF as compared to WO-BF. There was no significant difference between the W-BF and WO-BF groups regarding image quality (p=0.179).
Conclusion: By using biofeedback prior to elective CCTA beta-blocker use can be significantly decreased due to effective reduction of HR, especially in patients with a HR above 80 bpm, without compromising CT image quality and analysis.
Long-term Rainfall Trends in South West Asia - Arabian Peninsula
Authors: Maghrabi Abdullrahman H. , Alamoudi Hadeel A. , Alruhaili Aied S. 
Published: December 2022

Abstract

In this study, rainfall data from 19 stations in Saudi Arabia (SA) for the period 1985–2019 was utilized to investigate interannual, monthly, and seasonal rainfall variations and trends. The magnitudes of these trends were characterized and tested using Mann–Kendall (MK) rank statistics at different significance levels. During this study period, the mean rainfall in SA showed a slight and significant decreasing trend by about 2 mm/35 years. Investigation of seasonal trends of rainfall revealed that Winter and Spring rainfall decreased significantly by 2.7 mm/35 years and 5.4 mm//35 years respectively. Three months showed very slight significant decreasing trends of rainfall. These were the months of February, March and April. Mann-Kendall analyses were carried out to investigate the annual trends of rainfall during three sub-periods, i.e., 1985–1996, 1997–2008, and 2009–2019. The results revealed that while rainfall increased by 5.3 mm/12 years and 7.8 mm/11 years for the first and the third periods respectively, it decreased by about 11 mm/12 years during the second period. While trends of rainfall in Saudi Arabia are affected by large scale circulations and local factors, the effect of extraterrestrial factors, such as solar activity and its consequent effects on the climate may, additionally, play a potential role in affecting the pattern of rainfall in Saudi Arabia.
The crystal structure of feitknechtite (β-MnOOH) and a new MnOOH polymorph
Authors: Post Jeffrey E. , Heaney Peter J. , Ilton Eugene S. , Elzinga Evert J. 
Published: December 2022

Abstract
Studies suggest that feitknechtite (β-MnOOH) is a prevalent, and perhaps necessary, intermediate phase during the synthesis of birnessite-like phases, the abiotic oxidation of Mn2+, and the transformation of biogenic hexagonal phyllomanganates to more complex Mn oxides in laboratory and natural systems. Researchers have generally described feitknechtite as consisting of pyrochroite-like (or cadmium iodide-like) Mn-O octahedral layers, but a detailed crystal structure has not been reported. We used TEM/SAED and powder XRD and Rietveld refinements to derive the unit cell and, for the first time, report a complete structure description for feitknechtite (β-MnOOH). Rietveld refinements were also completed for three natural feitknechtite/hausmannite samples, and time-resolved synchrotron XRD experiments were used to follow the thermal transformation of feitknechtite to hausmannite. Additionally, we identified and report the structure for a second, and perhaps novel, MnOOH polymorph (proposed designation ε-MnOOH), mixed with the synthetic feitknechtite, that is similar to β-MnOOH but with a different layer stacking.
Hydroinformatics impact on hydrological modelling
Authors: Refsgaard J. C. , Erlich M. , Bathurst J. 
Published: December 2022

Abstract
Mike Abbott was an outsider to hydrological science, who nevertheless fundamentally advanced hydrological modelling by introducing knowledge from computational hydraulics and later hydroinformatics. His main contribution was the development of the concept of physically based distributed modelling and the European Hydrological System - Système Hydrologique Européen ‘SHE’, in a programme, which he initiated and led during the period 1975-1986, by forging a strong collaboration between public and private European research institutes and companies. The development of the SHE was a pioneering effort resulting in a quantum leap in hydrological modelling at its time of development. Technologically, the SHE remained for the next 1-2 decades the most advanced hydrological modelling system and it is still in use today, around 40 years after its birth. The SHE modelling philosophy was both challenged and imitated during these years. This chapter describes the obstacles to and the achievements of the SHE development, along with the first application studies and the debates generated by the scientific challenges to the SHE concept. The chapter also describes how Mike Abbott's ideas on encapsulation of knowledge in the so-called fourth-generation software systems inspired the development of user-friendly software packages, enabling professionals with domain understanding but without computer knowledge to use models. Further, the chapter describes Mike Abbott's vision of using intelligent hydroinformatics software systems to empower stakeholders and in this way democratise the decision-making processes and ensure social justice in the water sector, and briefly discusses why this vision, in contrast to the very successful ideas related to the SHE and the fourth-generation systems, had limited impact so far. Finally, the chapter discusses the strengths and weaknesses of Mike Abbott's contributions to hydrological modelling seen from today's state of the art and the impacts his contributions continue to have on hydrological modelling today.
Ivabradine for Uncontrolled Sinus Tachycardia in Thyrotoxic Cardiomyopathy
- Case Report
Authors: Frenkel Amit , Bichovsky Yoav , Arotsker Natan , Besser Limor , Joshua Ben-Zion , Fraenkel Merav , Zahger Doron , Klein Moti 
Published: December 2022

Background:
Beta-blockers, mainly propranalol, are usually administered to control heart rate in patients with thyrotoxicosis, especially when congestive heart failure presents. However, when thyrotoxicosis is not controlled, heart rate may be difficult to control even with maximal doses of propranolol. This presentation alerts physicians to the possibility of using ivabradine, a selective inhibitor of the sinoatrial pacemaker, for the control of heart rate.

Case Presentation:
We present a 37-year-old woman with thyrotoxicosis and congestive heart failure whose heart rate was not controlled with a maximal dose of beta blockers during a thyroid storm. The addition of ivabradine, a selective inhibitor of the sinoatrial pacemaker, controlled her heart rate within 48 hours.

Conclusion:
Ivabradine should be considered in patients with thyrotoxicosis, including those with heart failure, in whom beta blockers are insufficient to control heart rate.
Investigation of the Underlying Mechanism of Zhibai Dihuang Pill in Treating Osteoporosis by using Network Pharmacology and Molecular Dynamics
Simulation
Authors: Chang Baosheng , Feng Yangyang , Zhang Liangliang , Zhao Chengjin , Li Nannan 
Published: December 2022

Background:
With society aging, the rising prevalence of osteoporosis (OP) has enormous
social and economic implications. At present, the Zhibai Dihuang pill has been clinically
applied in OP treatment and shown significant efficacy, but its underlying mechanism remains
unclear.

Aims:
This study was designed to explore the mechanism of the Zhibai Dihuang pill treating OP.

Methods:
In this study, the active ingredients and corresponding targets in the Zhibai Dihuang pill
were searched using the TCMSP platform. Based on the mRNA expression data of OP patients in
the GEO database, differential expression analysis was conducted by bioinformatics means. By
using the differentially expressed genes (DEGs), protein-protein interaction (PPI) network was
constructed, and random walk with restart (RWR) analysis based on seed genes intersected from
DEGs and drug target genes was conducted. On this basis, the drug-active ingredient-gene interaction
network was built. The topological property of the network (degree) was statistically analyzed
to find the key therapeutic target AKT1 for the treatment of OP. Molecular docking between
AKT1 and the active ingredients was conducted, and according to the affinity score, diosgenin was
determined as the key small molecule of the Zhibai Dihuang pill in OP treatment. Based on molecular
dynamics simulation and cellular thermal shift assay validation, it was found that diosgenin
had a good binding ability with AKT1.

Results:
Cell experiments showed that diosgenin could affect the expression of bone markers and
the mineralization of extracellular matrix in mouse osteoblasts by inhibiting the phosphorylation
of AKT1, thus achieving the effect of OP treatment.

Conclusion:
Based on network pharmacology, this study clarified the key small molecule compounds
in the Zhibai Dihuang pill and their action targets and preliminarily analyzed the molecular
mechanism of the Zhibai Dihuang pill treating OP, providing a theoretical basis for the clinical use
of the Zhibai Dihuang pill.
Artesunate Reverses Clozapine-induced Lipid Metabolism Disorder in
BRL-3A Cells by Effecting AMPK Pathway
Authors: Cui Yali , Ling Lingyun , Huang Qingjun , Xu Haiyun 
Published: December 2022

Background:
Clozapine (CLZ) is the only registered drug for treatment-resistant schizophrenia
and also associated with metabolic abnormalities, including obesity, hyperglycemia, and
dyslipidemia.

Objective:
This study aimed to examine the effects of CLZ on lipid metabolism in BRL-3A cells,
measure possible effects of artesunate (ART) on the CLZ-induced alterations in lipid metabolism,
and explore the molecular mechanism underlying the CLZ- and ART-induced changes in the cells.

Methods:
BRL-3A cells were cultured in DMEM at different conditions in the CLZ experiment (20,
30, or 40 μM CLZ), CLZ-ART experiment (40 μM CLZ followed by ART at 5, 10, or 20 μM), or
CLZ-ART experiment consisting DMSO, CLZ, CLZ+ART, and ART groups. In addition to cell
viability assessment, triglyceride, total and free cholesterol in BRL-3A cells were measured by biochemistry
analyses, and levels of lipid metabolism-related genes and relevant proteins were evaluated
by means of quantitative PCR and Western blot.

Results:
CLZ in the used range increased levels of free and total cholesterol in BRL-3A while upregulated
mRNA levels of HMGCR, PPARα, and PPARγ. Moreover, the treatment increased
SREBP-1c mRNA and protein levels in the cells, although it showed no impact on the phosphorylation
of AMPK. ART treatment following CLZ exposure reversed the CLZ-induced high levels of
free and total cholesterol in BRL-3A. ART effectively ameliorated or normalized the CLZ-induced
changes in the HMGCR, PPARα, PPARγ, and SREBP-1c. Furthermore, ART increased AMPK
phosphorylation in BRL-3A.

Conclusion:
These results suggest that ART exerts a cholesterol-lowering effect in BRL-3A by affecting
the AMPK/SREBP-1c/PPARγ pathway.