bluuebunny/crossref_metadata_2025_split huggingface dataset:
The First Description of Acute Compartment Syndrome, by Al-Zahrawi
Authors: Aslanabadi Arash , Zare Zakieh , Aslanabadi Majid 
Published: August 2022

Abstract:
Acute compartment syndrome (ACS) is defined as increased pressure within a confined compartmental space, leading to a decline in the perfusion pressure of the tissue within that compartment. To date, the commonly held belief has been that ACS was first described by Richard von Volkmann in 1881. However, we propose that ACS was originally described by Abul Qasim Al-Zahrawi approximately 900 years earlier.
Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression
Authors: Delgado-Diaz David Jose , Jesaveluk Brianna , Hayward Joshua A. , Tyssen David , Alisoltani Arghavan , Potgieter Matthys , Bell Liam , Ross Elizabeth , Iranzadeh Arash , Allali Imane , Dabee Smritee , Barnabas Shaun , Gamieldien Hoyam , Blackburn Jonathan M. , Mulder Nicola , Smith Steven B. , Edwards Vonetta L. , Burgener Adam D , Bekker Linda-Gail , Ravel Jacques , Passmore Jo-Ann S. , Masson Lindi , Hearps Anna C. , Tachedjian Gilda 
Published: August 2022

Abstract
Background: Women with a cervicovaginal microbiota dominated by Lactobacillus spp. are at reduced risk of acquiring sexually transmitted infections including HIV but the biological mechanisms involved remain poorly defined. Here we performed metaproteomics on vaginal swab samples from young South African women (n=113) and transcriptomics analysis of cervicovaginal epithelial cell cultures to examine the ability of lactic acid, a metabolite produced by cervicovaginal lactobacilli, to modulate genital epithelial barrier function. Results: Compared to women with Lactobacillus-depleted microbiota, women dominated by vaginal lactobacilli exhibit higher abundance of bacterial lactate dehydrogenase, a key enzyme responsible for lactic acid production, which is independently associated with an increased abundance of epithelial barrier proteins. Physiological concentrations of lactic acid enhance epithelial cell culture barrier integrity and increase intercellular junctional molecule expression. Conclusions: These findings reveal a novel ability of vaginal lactic acid to enhance genital epithelial barrier integrity that may help prevent invasion by sexually transmitted pathogens.
An Optimized Deep Features Based Intrusion Detection Framework for the Wireless Networks
Authors: Majjaru ChandraBabu , K Senthilkumar 
Published: August 2022

Abstract
Nowadays, Internet-of-things (IoT) facilities have been used worldwide in all digital applications. Hence, maintaining the IoT communication system's security range is crucial to enrich the IoT advanced better. However, the harmful attacks can destroy security and degrade the IoT communication channel by making network traffic, system shutdown, and collapse. The present work has introduced a novel Frog Leap-based Hyper-parameter Tuned Deep Neural (FLbHTDN) model to overcome these issues to detect intrusion in the IoT communication paradigm. Hence, the dataset called Nsl-Kdd has been utilized to validate the pressed model. Initially, the preprocessing process functioned to remove the error from the trained dataset. Consequently, the present features in the dataset have been tracked, and the malicious features have been extracted and classified as specific attack classes. The designed model is executed in the Java platform, and the improvement measure of the developed technique has been validated by performing the comparative analysis. The proposed FLbHTDN approach has obtained the finest attack prediction score in less duration than the compared models.
Outcome and learning curve for laparoscopic intra-corporeal inguinal hernia repair in children
Authors: Fung Adrian Chi Heng , Chan Ivy Hau Yee , Wong Kenneth Kak Yuen 
Published: August 2022

Abstract
Background
Laparoscopic inguinal hernia repair is one of the procedures most commonly performed by paediatric surgeons. Current research on the learning curve for laparoscopic hernia repair in children is scarce. This study aims to evaluate the clinical outcome and learning curve of laparoscopic intra-corporeal inguinal hernia repair in children.
Methods
A retrospective single-centre analysis of all paediatric patients who underwent laparoscopic intra-corporeal inguinal hernia repair between 2010 and 2019 was performed. The clinical outcomes were analysed. The data on the achievement of the learning curve by surgical trainees were evaluated with the CUSUM technique, focusing on operative time.
Results
There were 719 patients with laparoscopic intra-corporeal inguinal hernia repair (comprising 1051 sides) performed during the study period. The overall ipsilateral recurrence rate was 1.8% without other complications detected. CUSUM analysis showed that there were 3 phases of training, for which the trainees underwent initial learning phase (Phase 1) for the first 7 cases. After mastering of the skills and extrapolating the skills to male patients with smaller body size (Phase 2), they then achieved performance comparable to that of the senior surgeons after 18 procedures (Phase 3).
Conclusions
18 procedures seem to be the number required to reach the learning curve plateau in terms of operative time by surgical trainees. The clinical outcomes show that laparoscopic intra-corporeal inguinal hernia repair is a safe and transferrable technique, even in the hands of trainees, with adequate supervision and careful case selection. It also provides skill acquisition for minimally invasive surgery.
Usefulness of the Combination of FilmArray and procalcitonin in respiratory infections in the Pediatric Intensive Care Unit
Authors: Gonzalez Carolina Bonilla , Camargo-Agón Laura , Barrera Pedro Alexander , Rodríguez Sebastián Peña , Chain Alejandra Mal , Uribe Camila , Vera-Chamorro Jose Fernando 
Published: August 2022

Abstract
Introduction. Acute respiratory infections represent one of the main causes of preventable infant mortality and morbidity in children, and although a significate proportion of cases are of viral etiology, antibiotic treatment is the overly-excessive norm. Studies suggest that the combined use of serum procalcitonin (PCT) and polymerase chain reaction (PCR) multiplex (FilmArray) may be used to guide antibiotic therapy. Methods. A prospective cohort study was conducted of patients between 1 month and 17 years of age with acute respiratory infection hospitalized in the PICU with a negative viral panel report and both respiratory FilmArray and procalcitonin performed in the first 72 hours of hospitalization. A diagnostic algorithm was then applied to these patients, tailored to the result of both tests. Results. Of the total 326 patients recluted, 110 met the inclusion criteria; 23 patients were excluded for infections other than respiratory origin. Of the 87 remaining patients, all had a respiratory FilmArray performed prior to the PCT sample, demonstrating a diagnostic yield of over 80%. Procalcitonin was requested in slightly more than half of the patients and was positive in a third of these cases. When combined in the diagnostic algorithm, FilmAray and PCT lead to changes in treatment plan in 30% of patients in terms of antibiotic management prescribed on admission, with the most frequent treatment plan change being suspending the antibiotic altogether (from 41.4% to 10.3%, for a total of 89.7% of patients without antibiotic therapy following the algorithm. None of the patients died and only 1/87 patients required re-initiating antibiotics after having suspended treatment. The interaction between the identification of a viral pathogen in the FilmArray and a negative PCT result yielded statistically significant results (p=0.004) and affected the change in treatment management mainly in antibiotic discontinuation.Conclusions. The combined use of FilmArray and serum PCT as tools in the diagnostic algorithm is a safe way to guide tailored antibiotic therapy in pediatric patients with ARI in critical state.
Manufacturing agglomeration, urban form and haze pollution
Authors: Wei Jishi , Ye Yunling , Yu Haichao 
Published: August 2022

Abstract
Manufacturing agglomeration promotes rapid economic development while also causing severe environmental pollution. This paper investigates the impact and mechanism of manufacturing agglomeration on haze pollution from the Chinese city level. Furthermore, we discuss the moderating effect and threshold effect of the three urban forms of urban external shape complexity, urban compactness, and urban fragmentation on the relationship between the two. The result shows: (1) The aggregation of the manufacturing industry presents an inverted U-shaped characteristic of promoting first and then inhibiting haze pollution in China's overall, eastern and central regions. (2) The complexity of the city's external shape and the city's fragmentation has a positive moderating effect on the relationship between manufacturing agglomeration and haze pollution. And urban fragmentation shows a negative moderating effect on the relationship between the two when the level of manufacturing agglomeration is on the right side of the inverted U-shaped curve. (3) The urban form shows a significant double threshold characteristic for haze pollution, increasing the complexity of the city's external shape and the city's fragmentation. The agglomeration of manufacturing shows the characteristics of first inhibiting and then promoting haze pollution. As urban compactness increases, the inhibitory effect of manufacturing agglomeration on haze pollution increases.
Degradation of cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) using ozone process: influencing factors and mechanism
Authors: Yan Boyin , Han Chunyu , Liu Zhiquan , Wu Guizhi , Wang Songxue , Li Jincheng , Xia Wenxiang , Cui Fuyi 
Published: August 2022

Abstract
β-N-methylamino-L-alanine (BMAA) is a new kind of cyanobacterial neurotoxin, which is widely present in water sources contaminated by algae and may threaten human health through drinking water. The ozone process is an advanced water treatment process widely used in drinking water treatment plants. In this work, the effectiveness of ozone oxidative degradation of BMAA was systematically explored, and the effect of operating parameters on the effectiveness of ozone oxidative degradation of BMAA was investigated, and the degradation mechanism of ozone oxidative degradation of BMAA was speculated. The results showed that BMAA could be quickly eliminated by ozone, and the removal rates of BMAA were nearly 100% in pure water, but the removal rates were reduced in actual water. BMAA was primarily degraded by direct oxidation of ozone molecules in acidic and near-neutral conditions, and indirect oxidation of •OH accounted for the main part under strong alkaline conditions. The pH value had a significant effect on the decomposition of BMAA, and the degradation rate of BMAA was fastest at near neutral pH value. The degradation rates of TOC were significantly lower than that of BMAA, indicating that by-products were generated during the degradation process. Three by-products ([M-H]+ = 105, 90 and 88) were identified by UPLC-MS/MS and the degradation pathways of BMAA were proposed. The production of by-products was attributed to the fracture of the C-N bonds. This work is helpful for the in-depth understanding on the mechanism and demonstration of the feasibility of the oxidation of BMAA by the ozone process.
Angiotensin II-pretreated hucMSCs attenuate inflammation and reverse pulmonary fibrosis in SD rat lung
Authors: Wang Wei , Song Aishi , Deng Weiyue , Zhang Yuying , Mukama Omar , Habimana Jean de Dieu , Xie Wei , Zhou Peng , Li Amy L. , Li Jiaxing , Deng Sihao , Ni Bin , Peng Kexin , Zhang Shusheng , Yan Xiaoxin , Huang Jufang , Li Zhiyuan 
Published: August 2022

Abstract
Background: Pulmonary fibrosis (PF) is an irreversible disease with a poor prognosis and a serious impact on patients' health. PF is also associated with COVID-19, especially in immunocompromised people. Herein, efforts have been made to treat PF using pretreatment of human umbilical cord mesenchymal stem cells (hucMSCs) with angiotensin II (Ang II) as a novel therapeutic method. Methods: PF model of Sprague Dawley (SD) rats were established by tracheal injection of bleomycin (BLM) (5U/Kg). On day 15 after modeling, PBS, hucMSCs or hucMSCs-Ang II were injected into tail vein. On the 23rd day after modeling, samples were taken and corresponding indexes were tested.Results: Our results first showed that Ang II pretreatment induced more hucMSCs to reach the injured lung and alleviated pulmonary fibrosis. Transplantation of hucMSCs-Ang II reduced inflammatory infiltration, increased IL-10 expression and enhanced macrophage matrix-metallopeptidase-9 (MMP-9) expression for collagen degradation. Moreover, the Ang II-treated hucMSCs decreased hydroxyproline (HYP) and alpha-smooth muscle actin (α-SMA) expression in SD rats and promoted collagen and collagen fiber degradation.Conclusions: Ang II pretreatment enhanced the homing ability of hucMSCs, and hucMSCs-Ang II transplantation reversed PF by inhibiting inflammation and promoting collagen and collagen fiber degradation, promising its clinical application in the treatment of post-inflammatory PF caused by various disorders, including COVID-19 and related pneumonia.
Operando Spectroscopic Insight into the Synergistic Catalysis on Dual-hetero-atom Sites in Zinc-air Battery
Authors: Sun Zhiguo , Zhang Huijuan , Cao Linlin , Ru Sen , Liu Xiaokang , Wu Dan , Shen Xinyi , Zhang Xue , Chen Zihang , Luo Qiquan , Xu Faqiang , Yao Tao 
Published: August 2022

Abstract
The construction and understanding of synergy in well-defined dual-atom active sites is an available avenue for promoting the multistep tandem catalytic reaction. Herein, guiding by the theoretical screening, we construct a dual-hetero-atom catalyst that comprises adjacent Cu-N4 and Se-C3 active sites for high-efficiency Zn-air battery. Device-based operando X-ray absorption spectroscopy coupled with theoretical calculations provide in-depth insights into this dual-atom synergy mechanism during realistic Zn-air battery operation conditions. We demonstrate that foreign-heteroatom Se modulators can efficiently polarize the charge distribution around symmetrical Cu-N4 moieties, and serve as the synergistic site to facilitate the second oxygen reduction step, in which the key OOH*-(Cu1-N4) transforms to O*-(Se1-C2) intermediate on the dual-hetero-atom sites after gaining one electron. As a result, the Se modified dual-hetero-atom catalyst achieves ultrahigh ORR activity with a half-wave potential of 0.905 V vs. RHE and a maximum output power density of 206.5 mW cm-2 in Zn-air battery.
Optimization of Array System Configuration Using the Smoothed-Pad Algorithm
Authors: Batubara Mario , Manik Timbul , Sitompul Peberlin , Lathif Muthofa 
Published: August 2022

Abstract
The source of astronomical objects, in general, is a very far distance from the observation instrument so that the transmitted signal is received very small and is at risk of being disturbed by other sources around the receiving system. Therefore, the concept of multiple receivers with array interferometry configuration arrays is used to improve the quality of the source signal detected by the receiving system. The position of each receiving system, known as the antenna pad, determines the quality performance of the received signal output. The antenna positions are arranged in a discrete grid system so that there is a vacancy between antenna pads. In this paper, a computational technique is present to overcome the region’s emptiness between one antenna to its neighbor. As an initial result, the integrating of each position with its neighboring pads with some of its smoothing functions is optimal in filling the void region and maximizing the u-v coverage.
Based annual classification of precipitation fallow period in dryland the Loess Plateau of China
Authors: Noor Hafeez , Min Sun , Li· Tingliang , Gao Zhiqiang 
Published: August 2022

Abstract
In order to clarify the relationship between wheat yield and precipitation in dryland region, the annual classification method of precipitation in fallow period was summarized in this paper by analyzing precipitation, precipitation distribution and its relationship with yield in Wenxi Experimental Base of Shanxi Province and major meteorological stations on the Loess Plateau from 1983 to 2020.The results showed that the average precipitation during fallow period was 296mm (coefficient of variation CV=10%), accounting for 58% (coefficient of variation CV=6%) of annual precipitation in the upland region of the Loess Plateau. With the increase of precipitation in fallow period, the wheat yield in dryland increased logarithmically (Y =2526.5 lnX-10148, R2=0.42, P<0.05). The method of annual classification of precipitation in fallow period. Divide the year type by annual precipitation, wet year: Pi>Pm + 0.33δ; Pm-0.33 δ≤ Pi ≤ Pm + 0.33δ; Dry years: Pi< Pm-0.33 δ, Pi was annual precipitation (mm); Pm is perennial average annual precipitation (mm); δ is mean variance of annual precipitation (mm). The proportion of perennial and humid fallow precipitation was lower than the multi-year average were defined as abnormal years, and the years in which the proportion of arid fallow precipitation was higher than the multi-year average were defined as abnormal years.
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for ovarian cancer in an Australian institution: Lessons from 20 years' experience
Authors: Farrell Rhonda , Liauw Winston , Morris David 
Published: August 2022

Abstract
Objectives: We report the 20-year experience of the largest Australian unit performing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for ovarian cancer and reflect on learning opportunities. Methods: A retrospective review of all cases of CRS for ovarian cancer at St George Peritonectomy Unit from Jan 1998- Jan 2018 was performed. Prospectively collected data include age, stage, histology, disease extent (PCI), completeness of cytoreduction (CC score), HIPEC regime, 30-day surgical morbidity, disease recurrence, and death. Survival was computed using Kaplan-Meier method and analysed using log-rank tests and Cox-proportional hazards models. Results: Forty-one women with advanced ovarian cancer (11 primary stage III/IV, 30 recurrent) underwent CRS, 29 (71%) with HIPEC. Most (68%) had high-volume disease (PCI >15). In 98%, CC0/CC1 (residual <2.5mm) was achieved. Fourteen (34%) had grade 3/4 complications, 1 patient (2%) died within 30 days and 2 patients (5%) died within 90 days. Progression-free and median overall survival was 30.0 and 67.0 months for primary cancer, and 6.7 and 18.1 months for recurrent cancer. Survival was associated with platinum-sensitivity, PCI£15, and CC score 0, but not HIPEC. Conclusion: This study reports outcomes for patients with advanced ovarian cancer patients treated in an Australian centre offering CRS and HIPEC. Whilst survival and morbidity outcomes were good for primary disease, they were poorer than predicted from the literature for cases of recurrent disease. The incorporation of evidence-based predictors of survival and multidisciplinary input are essential to achieve the best survival outcomes.
Dissemination and Genome Characterization of a Human Adenovirus F41 in a Patient with B-Cell Lymphoma
Authors: Fall Amary , Campodonico Victoria L. , Howard Craig , Gallagher Nicholas , Bailey Gabrielle , Kajon Adriana E. , Mostafa Heba H. 
Published: August 2022

Abstract
Adenovirus (HAdV) F41 is a common cause of gastroenteritis and has rarely been reported associated with disseminated disease. In this report, a fifty-eight-year-case with a history of ulcerative colitis, cryptogenic cirrhosis, stage III adenocarcinoma, high-grade diffuse large B-cell lymphoma on chemotherapy was diagnosed with disseminated adenovirus infection. HAdV DNA was quantified in stool, plasma, and urine with viral loads of 7, 4, and 3 log10 copies/mL, respectively. The patient’s course was rapidly progressive and he passed away 2 days after initiation of antiviral therapy. The patient’s infecting virus was characterized as HAdV-F41 by whole genome sequencing.
Cross-sectional uncertainties influences on sensitivity studies of DUNE and T2HK experiments
Authors: Devi Ritu , Singh Jaydip , Potukuchi Baba 
Published: August 2022

Abstract
The ultimate objectives of ongoing and upcoming neutrino experiments are the precise measurement of neutrino mixing parameters and the confirmation of mass hierarchy. The systematic inaccuracy in the cross-section models introduces inaccuracy in the neutrino mixing parameters
estimation. It is important to secure a large decrease of uncertainties, particularly those relating to cross-section, neutrino-nucleus interactions, and neutrino-energy reconstruction, in order to achieve these ambitious goals. In this research article, we use three alternative neutrino event
generators, GENIE, NuWro, and GiBUU, to analyze sensitivity studies of T2HK, DUNE, and combined sensitivity of DUNE, and T2HK for mass hierarchy, CP violation, and octant degeneracy caused by cross-section uncertainties. The cross-section models of these generators are separate
and independent.
Local environment drives rapid shifts in composition and phylogenetic clustering of seagrass microbiomes
Authors: Kardish Melissa , Stachowicz John 
Published: August 2022

Abstract
Plant microbiomes depend on environmental conditions, stochasticity, species, and genotype identity. Eelgrass (Zostera marina) is a unique system for plant-microbe interactions as a physiologically-challenged, marine angiosperm growing in anoxic sediment, periodic exposure to air at low tide, and gradients in water clarity and flow. We tested the influence of host origin versus environment on microbiome composition by transplanting 768 plants among four sites within Bodega Harbor, CA. Over three months following transplantation, we sampled microbial communities monthly on leaves and roots and sequenced the V4-V5 region of the 16S rRNA gene to assess community composition. The main driver of leaf and root microbiome composition was destination site; more modest effects of origin site did not last over a month. Community phylogenetic analyses suggested that environmental filtering structures these communities, but the strength and nature of this filtering varies among sites and over time. We demonstrate that local environmental differences create rapid shifts in associated microbial community composition with potential functional implications for hosts under shifting environmental conditions.
Study on Amino-functionalized Porous Carbon Materials for MB and Cr (VI) Adsorption
Authors: Song Jie , Chen Lijun , Niu Yuhua , Han Yuying , Sun Yonghui 
Published: August 2022

Abstract
From the perspective of environmental protection, high removal rate, reusability and degradability, Amino-functionalized porous hydrogel material P-(EA-β-CD/KHA/AC) was synthesized by introducing ethylamino cyclodextrin, humic acid and activated carbon, using polyacrylic acid as the carrier. The gel materials before and after adsorption were characterized by FTIR, XRD and XPS. The removal of organic matter (MB) and heavy metal ions (Cr (VI)) showed high adsorption capacity. At 298K and pH 8, the adsorption capacity of P-(EA-β-CD/KHA/AC) hydrogel for MB and Cr (VI) was as high as 262.31mg/g, 170.12mg/g, and the removal rate was 98.96% and 70.27%. The adsorption behavior follows the pseudo-second-order kinetic equation, conforming the Langmuir model, and through intermolecular forces, π-π conjugation, chelation and other interactions, an entropy-increasing, endothermic, and spontaneous process is formed. The regeneration and degradability experiments of P-(EA-β-CD/KHA/AC) hydrogel were carried out, verified that it has recycling performance, the weight loss rate of degradation in water and acid-base buffer solution for 6 months reached 45.82%, 28.25% and 30.70%, respectively.