bluuebunny/crossref_metadata_2025_split huggingface dataset:
Egyptian evidence-based consensus on clinical practice recommendations for the management of lupus nephritis
Authors: El Miedany Yasser , Kamel Nadia Salah , Abu-Zaid Mohammed Hassan , El Hadidi Khaled , Mahmoud Geilan Abdelmoneim , Sarhan Eman , El Gaafary Maha , Abdel-Nasser Ahmed , Abualfadl Esam M. , Azim Atef Abdel , Fathi Nihal Ahmed , Mokbel Abir , Hassan Waleed , Tabra Samar Abd Alhamed , Eissa Mervat , Mortada Mohamed , Fouad Nermeen Ahmed , Elnemr Rehab , Mansour Ahmed Ezzat , Elaraby Ismail , Medhat Basma M. , Mohamed Sally S. , Abdelradi Eman Ragab , Ibrahim Rehab Ali , Saber Sally 
Published: September 2022

Abstract
Background
Lupus nephritis (LN) affects a substantial number of the patients living with Systemic lupus erythematosus (SLE), representing a major cause of morbidity and mortality. Patients with lupus nephritis should be referred to a lupus nephritis expert who can confirm the diagnosis, assess the level of disease activity, and offer guidance on treatment and monitoring of the disease, as well as its consequences and side effects. The aim of this guideline was to develop recommendations for the management of adult lupus patients, including lupus nephritis diagnosis, assessment, and monitoring.
Nineteen key clinical questions were identified by scientific committee according to the Patient/Population, Intervention, Comparison, Outcomes and Timing (PICOT) approach. Literature review team performed a systematic review to summarize evidence advocating the benefits and harms of available pharmacologic and nonpharmacologic therapies for LN. Subsequently, recommendations were formulated. The level of evidence was determined for each section using the Oxford Centre for Evidence-based Medicine (CEBM) system. A 2-round Delphi process was conducted with 24 experts. All rounds were conducted online. A consensus was achieved on the direction and the strength of the recommendations.

Results
An online questionnaire was sent to an expert panel who participated in the two rounds (response rate 100%). At the end of round 2, a total of 19 recommendation items, categorized into 11 sections to address the main LN categories, were obtained. The percentage of those who agreed with the recommendations (ranks 7–9) ranged from 90.5 to 100%. The phrasing of all 19 clinical standards identified by the scientific committee was agreed upon (i.e., 75% of respondents strongly agreed or agreed).

Conclusion
These recommendations provide an updated consensus on the pharmacological treatment of lupus nephritis and strategies to reach optimal treat to target outcomes in common clinical scenarios, based on a combination of evidence and expert opinion. Best treatment decisions should be tailored to each individual patient situation.
Necroptosis at a glance
Authors: Kang Kidong , Park Christa , Chan Francis Ka-Ming 
Published: September 2022

ABSTRACT
Necroptosis, or programmed necrosis, is an inflammatory form of cell death with important functions in host defense against pathogens and tissue homeostasis. The four cytosolic receptor-interacting protein kinase homotypic interaction motif (RHIM)-containing adaptor proteins RIPK1, RIPK3, TRIF (also known as TICAM1) and ZBP1 mediate necroptosis induction in response to infection and cytokine or innate immune receptor activation. Activation of the RHIM adaptors leads to phosphorylation, oligomerization and membrane targeting of the necroptosis effector protein mixed lineage kinase domain-like (MLKL). Active MLKL induces lesions on the plasma membrane, leading to the release of pro-inflammatory damage-associated molecular patterns (DAMPs). Thus, activities of the RHIM adaptors and MLKL are tightly regulated by posttranslational modifications to prevent inadvertent release of immunogenic contents. In this Cell Science at a Glance article and the accompanying poster, we provide an overview of the regulatory mechanisms of necroptosis and its biological functions in tissue homeostasis, pathogen infection and other inflammatory diseases.
Effectiveness of stretching exercises in conservative therapy of plantar fasciitis (PF)
Authors: Kowal Alicja , Spozowski Karol 
Published: September 2022

Introduction and objective: Plantar fasciitis affects both young active patients and older people leading a sedentary lifestyle. It is result from chronic overload of the plantar fascia. About 80% of patients with plantar fasciitis improve within 12 months with non-surgical treatment. Nonsurgical management includes e.g. activity modification, cooling, non-steroidal anti-inflammatory drugs, stretching and strengthening exercises and manual therapy.

Materials and methods: PubMed database was searched. The criteria for qualifying the articles for the review were the following keywords: plantar fasciitis, muscle stretching, exercise, manual therapy, heel spur. 11 articles from 2017 to 2022 were analyzed.

Description of the state of knowledge: Calf stretching is one of the treatments for plantar fasciitis with the best results in the long run. In turn, strengthening exercises turn out to be more effective in a short time. One should also not forget about influence other methods of conservative treatment, such as cooling, orthoses or physical therapy, that support and accelerate the treatment process.

Summary: Strengthening exercises of the plantar fascia are more effective than stretching in terms of reducing pain and improving function in the short term, while stretching exercises show better results in the long term. The best results are obtained by combining stretching of the triceps calf muscle with other methods of conservative treatment. There are no studies supporting the hypothesis that stretching alone is more effective in the treatment process than other methods and placebo.
Third-order nonlinear optical manifestations in an intramolecular proton transfer fluorophore due to Tamm-plasmon based broadband optical absorbers
Authors: Kumari Anupa , Nayak Prakash , Patra Bikash , Venkatasubbaiah Krishnan , Das Ritwick 
Published: September 2022

The imidazole ring has proven to be a very promising candidate for realizing molecular systems that facilitate efficient generation of broadband optical radiation using an excited-state intramolecular proton-transfer (ESIPT) mechanism. To obtain a targeted RGB-color composition, the conventional route is to create optimum mixtures of dyads and triads of non-interacting ESIPT molecules that cover the entire visible spectral band as well as restrict any energy transfer between wide bandgap donors and narrow bandgap acceptors. However, there is a need for alternate routes that can facilitate dynamic control over color composition during operation. The nonlinear optical (NLO) response of ESIPT fluorophores and configurations derived out of them could be explored from this perspective. In the present work, we design a

T
i
O

2

/

S
i
O

2

based distributed-Bragg-reflector (DBR) configuration with a terminating layer consisting of a film of an ESIPT fluorophore, namely, 2-(4,5-diphenyl-1-(4-(trifluoromethyl)phenyl)-1H-imidazol-2yl)phenol (DTIP). In the presence of thin Ag-film, the DTIP-DBR multilayer geometry supports a Tamm-plasmon-polariton (TPP) mode within the photonic bandgap of DBR, which exhibits an unusual spectral bandwidth greater than 50 nm. The open-aperture and closed-aperture Z-scan measurements reveal the strong TPP based broadband absorption that leads to reversal of third-order NLO characteristics, i.e., the multilayer geometry exhibits saturation absorption behavior at wavelengths where the bare DTIP fluorophore (in solution and film) shows a two-photon absorption signature.
Effectiveness of insecticide thermal fogging in hyrax dens in the control of leishmaniasis vectors in rural Palestine: A prospective study
Authors: Sawalha Samer , Al-Jawabreh Amer , Hjaija Dea , Ereqat Suheir , Nasereddin Abdelmajeed , Al-Jawabreh Hanan , Evlampidou Iro 
Published: September 2022

BackgroundZoonotic cutaneous leishmaniasis (ZCL) is endemic in Palestine and transmitted byPhlebotomussand flies. They inhabit dens of hyraxes, the reservoir animal. Control measures were implemented since 1996 but cases still occur. We estimated the effect of insecticide thermal fogging inside hyrax dens on sand fly density and leishmania infection.Methodology/Principal findingsDuring July-September 2019, we conducted a 12-week controlled interrupted time series study in two control and one intervention sites containing three hyrax dens each. We implemented Permethrin thermal fogging in the intervention site at week 6. We measured weekly and 36hrs post-intervention sand fly abundance inside dens using CDC light traps. We performed Next-Generation Sequencing to identify sand flyLeishmania spp. infection. We calculated the abundance reduction (AR) using Mulla’s formula and negative binomial regression. Among 11427 collected sand flies, 7339 (64%) were females and 1786 (16%) werePhlebotomus spp. comprising ten species;P.sergentiwas the dominant (n = 773, 43%). We reportP.arabicus(n = 6) for the first time in Palestine. After fogging,Phlebotomus spp. AR was 93% at 36hrs, 18% and 38% at two and five weeks respectively and 41% during the complete post-intervention period. In the regression models,Phlebotomus spp. density in the intervention site decreased by 74% (IRR: 0.26, 95%CI: 0.11–0.57) at two weeks, 34% (IRR: 0.66, 95%CI: 0.48–0.90) at five weeks and 74% (IRR: 0.26, 95%CI: 0.12–0.59) during the complete period. The density ofLeishmaniainfected sand flies decreased by 65% (IRR: 0.35, 95%CI: 0.26–0.48) at five weeks and 82% (IRR: 0.18, 95%CI: 0.07–0.42) for the complete period (zero infections until week two).Leishmaniainfection prevalence in the intervention site was 14% pre-intervention and 3.9% post-intervention.Conclusions/SignificanceFogging hyrax dens reduced sand fly abundance and leishmania infection during the 5-week post-intervention period and especially the first two weeks suggesting it could be an effective source-reduction measure for ZCL vectors. Future randomized controlled trials are needed to confirm the effectiveness of fogging hyrax dens on decreasing ZCL incidence.
Efficacy of a Second PPI Course After Steroid-Induced Remission in Eosinophilic Esophagitis Refractory to Initial PPI Therapy
Authors: Visaggi Pierfrancesco , Baiano Svizzero Federica , Del Corso Giulio , Bellini Massimo , Savarino Edoardo , de Bortoli Nicola 
Published: September 2022

INTRODUCTION:
Eosinophilic esophagitis (EoE) requires maintenance therapy to avoid recurrence. We investigated the efficacy of a second course of proton pump inhibitors (scPPIs) to maintain steroid-induced histological remission (HR) in patients with EoE who had previously failed induction of remission with PPIs.

METHODS:
We retrospectively included 18 patients who achieved HR with topical steroids but could not be maintained on long-term topical steroids. Treatment outcomes were assessed after 12 weeks of scPPIs.

RESULTS:
Most of the patients (67%) maintained HR with high-dose PPI monotherapy at week 12.

DISCUSSION:
scPPIs might work as a maintenance strategy in primary PPI nonresponder EoE patients.
Analisis Pengaruh Pendidikan, Kesehatan dan Upah Terhadap Produktivitas Tenaga Kerja di Provinsi Jawa Tengah
Authors: Puspasari Dwi 
Published: September 2022

Labor productivity is a describes of the capability of the worker in the resulting output. The higher of output produced by a worker, showed the higher of worker productivity levels. The quality of labor will affect the productivity of the output produced. Labor productivity in Province of Central Java is lower when compared with other provinces on the island of java. This research aims to analyze the impact of variable education, health and wage on labor productivity in Centra Java year of 2010-2015. The analytical method use in this study is panel data regression. The analytical method of this research is Fixed Effect Model (FEM).The result is variable education, health and wage is significant and has positive impact on labor producticity.
ANALISIS PENGARUH PERKEMBANGAN INDIKATOR SEKTOR KEUANGAN TERHADAP PERTUMBUHAN EKONOMI INDONESIA SELAMA TAHUN 1980-2019
Authors: Indrakusuma Devin Aska 
Published: September 2022

Perkembangan sektor keuangan akan meningkatkan permintaan jasa keuangan dan mendorong naiknya pertumbuhan ekonomi. Tujuan penelitian ini menganalisis pengaruh rasio broad money per PDB, rasio kredit per PDB, rasio investasi per PDB, dab rasio pengeluaran per PDB terhadap pertumbuhan ekonomi Indonesia selama tahun 1980-2019.Data indikator sektor keuangan dan pertumbuhan ekonomi merupakan data sekunder yang bersumber dari World Bank. Data merupakan data runut waktu dari tahun 1980-2019. Metode analisis data yang digunakan adalah Error Correction Model.Hasil penelitian menunjukkan rasio broad money per PDB, rasio kredit per PDB, dan rasio pengeluaran pemerintah per PDB terhadap pertumbuhan ekonomi positif signifikan jangka pendek dan jangka panjang. Rasio investasi per PDB terhadap pertumbuhan ekonomi positif signifikan dalam jangka panjang dan positif tidak signifikan dalam jangka pendek. Hasil penelitian ini menujukkan bahwa sektor keuangan berperan aktif dalam mendorong pertumbuhan ekonomi Indonesia.
Pemetaan Potensi Wilayah Guna Mendorong Pembangunan Ekonomi Kabupaten Ngawi
Authors: Widyaningrum Eka Dyah Ayu , Cahyono Hendry 
Published: September 2022

Kesejahteraan masyarakat berkaitan erat dengan peningkatan kualitas standar hidup diukur melalui Produk Domestik Bruto (PDB) pada tingkat nasional dan Produk Domestik Regional Bruto (PDRB) di tingkat kabupaten/kota. Dalam pembangunan nasional harus memperhatikan kondisi tiap daerah karena adanya perbedaan karakteristik, budaya, dan kondisi sosial. Sehingga, perlu diketahui sektor basis dan unggulan tiap daerah guna meningkatkan pembangunan ekonomi. Penelitian ini bertujuan untuk memetakan potensi Kabupaten Ngawi menggunakan data PDRB Kabupaten Ngawi tahun 2015-2019. Alat analisis yang digunakan yaitu Location Qoutient, (LQ), Analisis Shift-Share, Model Rasio Pertumbuhan (MRP), Analisis Overlay. Hasil analisis menunjukkan sektor basis di Kabupaten Ngawi yaitu pertanian; pengangkutan dan komunikasi; jasa-jasa. Dari hasil overlay menunjukkan sektor potensial di Kabupaten Ngawi terdiri dari perdagangan, hotel dan restoran; industri pengolahan; dan kontruksi. Sektor-sektor tersebut memiliki peluang untuk dikembangkan menjadi sektor unggulan. Sedangkan sektor unggulan di Kabupaten Ngawi terdiri dari angkutan dan komunikasi; jasa-jasa. Selama tahun analisis Kabupaten Ngawi mengalami pergeseran struktur ekonomi.
Decision Making Analysis on The Use of The Mobile Wallet As A Payment Transaction Tool (Case Study of Diponegoro University Students, Semarang)
Authors: Dewi Melati Kusuma , Sugiyanto FX 
Published: September 2022

This study aims to analyze factors affecting decision making on the use of mobile wallet as a payment instrument. The purpose of this study was to determine whether prices, risks, income, prices of other payment instrument, and risks payment instrument influence the decision to use mobile wallet as payment instrument. The study population was students of HIPMI PT Undip Semarang with a total sample of 100 respondents. The analysis used is validity, reliability and Binary Logistic Regression analysis. The results showed that: (1) Price had a positive and significant effect on the decision to use a mobile wallet. Lower price changes will increase the probability of using a mobile wallet. (2) Risk has a positive and not significant effect on the decision to use a mobile wallet. (3) Income has a negative and significant effect on the use of mobile wallet. Greater income will reduce the use of mobile wallet. (4) The price of other transaction instruments has a positive and not significant effect on the decision to use a mobile wallet. (5) The risk of other transaction instruments has a positive and not significant effect on the decision to use a mobile wallet.
THE INFLUENCE OF BUY 1 GET 1 PROMOTION ON THE SALES OF PRODUCTS IN CONSUMER ATTRACTION POWER
Authors: Majid Ahmad Abdul 
Published: September 2022

This study aims to determine whether sales promotions, the attractiveness of buy 1 get 1 can affect the product purchase . The appeal of consumers un tuk buy a product with the promotion of relatively high . Promotion is a communication activity carried out by a person or company with the community with the aim of allowing something (goods, services, brands, companies) to the community and at the same time influencing the wider community to buy and use the product. This type of research is carried out by the method of explanatory research or explanatory research with a quantitative approach. Variables used in this study include; cashback promotions, promotions, consumer purchasing power decisions. The population of this study is the wider community in DKI Jakarta, which was carried out randomly with a sample of 99 respondents taken using purposive sampling techniques and data collection methods using questionnaires. Analysis of the data used is descriptive analysis and path analysis.
Teaching and Learning Chemistry and Physics with a Laboratory Stations Model in a Flipped Classroom – A Preliminary Report
Authors: Coutinho Isabel Ribau 
Published: September 2022

This research presents the efforts, to help students, hindered during the COVID19 pandemic, to learn chemistry. With the pandemic, Portuguese students that enrolled in the 10th grade in September 2021, had lower experience in the experimental work, since practical classes at school were suspended from mars 2019 to September 2021. So, students had difficulties in measuring or working with simple laboratory apparatus. They had difficulties in giving meaning to the experimental procedure, describing an observation, collecting data, analyzing data, and interpreting the results. In this context, it was necessary to have a learning and teaching approach different from the one they had in the last three years, to develop the skills they need. The first proposal was to use “Practical work by laboratory stations but it was not enough in the present context. So, a new learning and teaching project that blended digital tools/platforms and practical work in the laboratory was conceived. This learning and teaching project uses hybrid learning environments, based on practical work by laboratory stations, developed according to the collaborative Peer Instruction approach in a flipped classroom environment. The project's main goals were to develop scientific skills (like planning, collecting data observing and measuring, classifying, quantifying, predicting, controlling variables, interpreting, forming conclusions, and communicating) and increase their motivation to learn Chemistry and Physics. But also study the impact of the flipped classroom with laboratory stations, on motivation, self-regulation of learning, the perception of self-efficacy to self-regulate learning and the perceived instrumentality of the self-regulation process. The study population is the students enrolled in the 10th grade (upper secondary school), in a school near Lisbon. The research project was implemented in two classes: one class were subject to the new approach (one in the 10 grade), and the other maintained the regular practice (the control group). In this paper, the results from the first year will be presented and discussed. The data were collected in two moments, in September 2021 and June 2020. The preliminary results, of this research, show that laboratory classes with the flipped room increase not only the motivation and involvement in the learning process but also, the learning outcomes as students become more involved in the tasks.
Evaluation method of ex vivo porcine liver reduced scattering coefficient during microwave ablation based on temperature
Authors: Jin Xiaofei , Liu Wenwen , Li Yiran , Qian Lu , Zhu Qiaoqiao , Li Weitao , Qian Zhiyu 
Published: September 2022

Abstract
The principle of microwave ablation (MWA) is to cause irreversible damage (protein coagulation, necrosis, etc.) to tumor cells at a certain temperature by heating, thereby destroying the tumor. We have long used functional near-infrared spectroscopy (fNIRs) to monitor clinical thermal ablation efficacy. After a lot of experimental verification, it can be found that there is a clear correlation between the reduced scattering coefficient and the degree of tissue damage. During the MWA process, the reduced scattering coefficient has a stable change. Therefore, both temperature (T) and reduced scattering coefficient (

μ
s
′

${\mu }_{s}^{\prime }$

) are related to the thermal damage of the tissue. This paper mainly studies the changing law of T and

μ
s
′

${\mu }_{s}^{\prime }$

during MWA and establishes a relationship model. The two-parameter simultaneous acquisition system was designed and used to obtain the T and

μ
s
′

${\mu }_{s}^{\prime }$

of the ex vivo porcine liver during MWA. The correlation model between T and

μ
s
′

${\mu }_{s}^{\prime }$

is established, enabling the quantitative estimation of

μ
s
′

${\mu }_{s}^{\prime }$

of porcine liver based on T. The maximum and the minimum relative errors of

μ
s
′

${\mu }_{s}^{\prime }$

are 79.01 and 0.39%, respectively. Through the electromagnetic simulation of the temperature field during MWA, 2D and 3D fields of reduced scattering coefficient can also be obtained using this correlation model. This study contributes to realize the preoperative simulation of the optical parameter field of microwave ablation and provide 2D/3D therapeutic effect for clinic.
Grammatically unstable placeholders and morpho-syntactic remedies: evidence from East Asian languages
Authors: Seraku Tohru , Park Sooyun , Yu Yile 
Published: September 2022

Abstract
When a communicator faces a word-formulation problem, they may use a placeholder (PH) such as whatchamacallit to avoid producing a target expression or to delay it. A PH is a dummy element used to fill in the syntactic slot of a target item that a communicator is unable or unwilling to produce (e.g. due to memory lapse). Previous studies have generally been concerned with grammatically stable PHs (e.g. whatchamacallit, you-know-what), ‘grammatically stable’ in the sense that they are acceptably used (as long as the syntactic, semantic, and pragmatic conditions are met) on their own, without a morphosyntactic aid. In this article, we describe ‘grammatically unstable’ wh-derived PHs in three East Asian languages: Japanese, Korean, and Mandarin. To give a specific example, typically, the PH use of Japanese dare ‘who’ is not fully acceptable unless it is doubled (i.e. dare∼dare) or combines with a non-wh element (e.g. dare-sore, where sore is the medial demonstrative ‘that’). We show that the types of such remedial morphosyntactic operations vary from language to language and also within a language.
A 4 × 210 Gbps high-speed optical wireless system in medium earth orbit (MEO) using matched filters and digital signal processing
Authors: Sachdeva Shippu , Sindhwani Manoj 
Published: September 2022

Abstract
In this work, a high-speed optical wireless system is realized to cater to the bandwidth demands of data services in inter-satellite by using 4 × 210 Gbps capacity enabled by dual-polarization (DP) 128-Quadrature amplitude modulation (QAM) at 25 GHz channel spacing and artificial intelligence (AI). For nonlinear compensation, equalization, normalization, and interference reduction, digital signal processing (DSP), and matched filters are included in the receiver. Results are analyzed by considering error vector magnitude (EVM), Q-factor, and BER at different link lengths. Moreover, two polarizations such as horizontal and vertical polarizations are investigated separately to find out optimal polarization state. Further comparison of the proposed DP-128 QAM is performed with quadrature phase-shift keying (QPSK)and results revealed that the QAM system carrying different states of polarization (SOPs) successfully covered 17,500 km at 125 Gbps and offered enhanced performance as compared to the conventional QPSK and QAM modulations due to narrow carrier spectrum (27 symbols).