bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Markov chain to share price movement in Nigeria (1985–2019)
Authors: Manasseh Charles O. , Iroha Nnah M. , Okere Kingsley I. , Nwakoby Ifeoma C. , Okanya Ogochukwu C. , Nwonye Nnenna , Odidi Onuselogu , Inyiama Oliver I. 
Published: December 2022

AbstractThe study evaluates the movement of share prices in the Nigerian stock market. Markov chain approach provides a successful analysis and prediction of time-series data (1985–2019) which reflects Markov dependency. The probability $$\alpha$$
α
and $$\beta$$
β
was estimated, and the expectation of the monthly increase (E(I)) and decrease (E(D)) of the share price index was obtained as 5 months and 3 months, respectively. The steady-state probabilities π1 and π2 were obtained as 0.335 and 0.665, respectively, independent of the initial conditions. The results observed that as the years rolled, the monthly share prices continued to increase due to increased activity in the stock market. In addition, further investigation shows that share price movement and stock market performance influence economic performance. Based on the findings, the Nigerian government and the market authorities should initiate policies that reduce arbitragers' ability to forecast and beat the markets to forestall investors' confidence. Hence, investor property rights protection, discouragement of insider trading, and ensuring that local or domestic investors are enlightened about the stock market and the inherent benefits in Nigeria will enhance stock market efficiency and growth.
Implication of bridge resilience design and lessons from negative examples
Authors: Wang Erqiang , Liu Zhao , Li Meishuai , Zhao Dongdong 
Published: December 2022

AbstractBridge resilience is a newly proposed bridge design criterion that involves robustness, redundancy and reparability targeting on the rapidity of functionality restoration after suffering extreme actions and long-term durability deterioration. It stipulates a lower probability of reaching the ultimate limit state or strength limit state, which have been only partly involved in bridge design codes around the world. In AASHTO LRFD Bridge Design Specifications and Eurocodes, there are some design principles related to bridge resilience. Yet, it is also necessary to give more requirements for structural ductility and collapse resistance when the actual load exceeds the load combination in the code. This paper focuses on the resilience-based principles for bridge design, and exposes some problematic bridge structural systems and details, such as bridges most likely to overturning, steel bridges with fracture critical members, arch bridges with suspended desk, Morandi cable-stayed bridges, poor details for seismic vulnerability, etc. Whereas overturning is one of the worst anti-resilience scenarios, the resilience design against bridge overturning is highlighted through a detailed discussion including the calculation methods of anti-overturning factor, overturning stability of curved bridges, reasonable disposition of supports, and anti-overturning countermeasures.
Valvular and aortic surgery in an adult patient late after repaired tetralogy of Fallot
Authors: Nomura Ryuya , Furukawa Kojiro , Fukuda Tomofumi , Hirata Yuichiro , Onzuka Tatsushi , Ohtani Kisho , Imasaka Ken-ichi , Morita Shigeki , Shiose Akira 
Published: December 2022

Abstract
Background
The most common complication after tetralogy of Fallot repair is pulmonary valve regurgitation. However, concomitant surgery for tricuspid valve regurgitation and/or aortic dilatation is occasionally required.

Case presentation
A 56-year-old woman who underwent surgery for tetralogy of Fallot at age 29 years was diagnosed with progressive tricuspid valve regurgitation, hepatosplenomegaly, and thrombocytopenia. Moreover, computed tomography and transesophageal echocardiography revealed regurgitation in pulmonary and mitral valves and dilatation of the ascending aorta. One month after splenectomy for increasing platelet count, she underwent pulmonary valve replacement, tricuspid and mitral valve annuloplasty, and ascending aortic replacement. Postoperatively, the intensive care stay was complicated because of ventricular dysfunction and long-term ventilation. After 1 week, the patient was disconnected from the respirator, and she was transferred on the 55th postoperative day to another hospital for rehabilitation, without permanent disabilities.

Conclusion
We herein reported a patient with repaired TOF who successfully underwent PVR, tricuspid and mitral valve annuloplasty, and ascending aortic replacement.
OPTIMAL Breast Cancer Care: Effect of an Outpatient Pharmacy Team to Improve Management and Adherence to Oral Cancer Treatment
Authors: Patel Jasmine V. , Hughes David M. , Ko Naomi Y. 
Published: December 2022

PURPOSE: Since the approval of cyclin‐dependent kinase 4/6 inhibitors in 2015, this oral cancer (OC) therapy has been combined with oral endocrine therapy as first-line treatment in metastatic hormone receptor–positive breast cancer, adding unique toxicity and complexity to the successful administration of this oral medication. Implementation of OC is challenging because of delays in treatment and nonadherence and is worse among vulnerable patient populations. Pharmacists may mitigate these barriers with facilitation of prior authorizations, communication with pharmacies, toxicity management, adherence counseling, and optimization of dosing schedules and regimens. MATERIALS AND METHODS: We conducted a quality improvement project to decrease the average number of treatment day delays during the first six cycles of OC. Patients were enrolled on the OPTIMAL protocol, a high-touch pharmacy intervention incorporating pharmacists within outpatient oncology clinic visits with the providers. Pharmacists met with patients, identified individual barriers to treatment, and performed counseling including toxicity and adherence assessments. RESULTS: A preintervention assessment identified an average treatment day delay of 7.7 (range, 3.2-15.3) days during the first six cycles of OC. During the intervention period, 53 patients were enrolled on the OPTIMAL protocol and experienced an average treatment day delay of 2.1 (0.6-4) days, P < .0001. Delays were characterized as modifiable and unmodifiable. Pharmacists documented 640 interventions, including medication reconciliations and clinical recommendations. Forty-two patients reported treatment-related toxicities, resulting in 33 therapy and 20 dose modifications. CONCLUSION: Our initiative to incorporate pharmacists in clinic visits at an outpatient breast cancer clinic was associated with decreased treatment day delays during the first six cycles of treatment. Pharmacists performed a multitude of meaningful interventions to facilitate treatment in a particularly vulnerable population and play a valuable role in comanaging patients.
Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care
Authors: Cuppen Edwin , Elemento Olivier , Rosenquist Richard , Nikic Svetlana , IJzerman Maarten , Zaleski Isabelle Durand , Frederix Geert , Levin Lars-Åke , Mullighan Charles G. , Buettner Reinhard , Pugh Trevor J. , Grimmond Sean , Caldas Carlos , Andre Fabrice , Custers Ilse , Campo Elias , van Snellenberg Hans , Schuh Anna , Nakagawa Hidewaki , von Kalle Christof , Haferlach Torsten , Fröhling Stefan , Jobanputra Vaidehi 
Published: December 2022

PURPOSE The combination of whole-genome and transcriptome sequencing (WGTS) is expected to transform diagnosis and treatment for patients with cancer. WGTS is a comprehensive precision diagnostic test that is starting to replace the standard of care for oncology molecular testing in health care systems around the world; however, the implementation and widescale adoption of this best-in-class testing is lacking. METHODS Here, we address the barriers in integrating WGTS for cancer diagnostics and treatment selection and answer questions regarding utility in different cancer types, cost-effectiveness and affordability, and other practical considerations for WGTS implementation. RESULTS We review the current studies implementing WGTS in health care systems and provide a synopsis of the clinical evidence and insights into practical considerations for WGTS implementation. We reflect on regulatory, costs, reimbursement, and incidental findings aspects of this test. CONCLUSION WGTS is an appropriate comprehensive clinical test for many tumor types and can replace multiple, cascade testing approaches currently performed. Decreasing sequencing cost, increasing number of clinically relevant aberrations and discovery of more complex biomarkers of treatment response, should pave the way for health care systems and laboratories in implementing WGTS into clinical practice, to transform diagnosis and treatment for patients with cancer.
Analysis of Circulating Tumor DNA to Predict Risk of Recurrence in Patients With Esophageal and Gastric Cancers
Authors: Huffman Brandon M. , Aushev Vasily N. , Budde Griffin L. , Chao Joseph , Dayyani Farshid , Hanna Diana , Botta Gregory P. , Catenacci Daniel V.T. , Maron Steven B. , Krinshpun Shifra , Sharma Shruti , George Giby V. , Malhotra Meenakshi , Jurdi Adham , Moshkevich Solomon , Aleshin Alexey , Kasi Pashtoon M. , Klempner Samuel J. 
Published: December 2022

PURPOSE Circulating tumor DNA (ctDNA) analyses allow for postoperative risk stratification in patients with curatively treated colon and breast cancers. Use of ctDNA in esophagogastric cancers (EGC) is less characterized and could identify high-risk patients who have been treated with curative intent. METHODS In this retrospective analysis of real-world data, ctDNA levels were analyzed in the preoperative, postoperative, and surveillance settings in patients with EGC using a personalized multiplex polymerase chain reaction–based next-generation sequencing assay. Plasma samples (n = 943) from 295 patients at > 70 institutions were collected before surgery, postoperatively, and/or serially during routine clinical follow-up from September 19, 2019, to February 21, 2022. ctDNA detection was annotated to clinicopathologic features and recurrence-free survival. RESULTS A total of 295 patients with EGC were analyzed, and 212 patients with stages I-III disease were further explored. Pretreatment ctDNA was detected in 96% (23/24) of patients with preoperative time points. Postoperative ctDNA was detected in 23.5% (16/68) of patients with stage I-III EGC within 16 weeks (molecular residual disease window) after surgery without receiving systemic therapy. ctDNA detection at any time point after surgery (hazard ratio [HR], 23.6; 95% CI, 10.2 to 66.0; P < .0001), within the molecular residual disease window (HR, 10.7; 95% CI, 4.3 to 29.3; P < .0001), and during the surveillance period (HR, 17.7; 95% CI, 7.3 to 50.7; P < .0001) was associated with shorter recurrence-free survival. In multivariable analysis, ctDNA status and clinical stage of disease were independently associated with outcomes. CONCLUSION Using real-world data, we demonstrate that postoperative tumor-informed ctDNA detection in EGC is feasible and allows for enhanced patient risk stratification and prognostication during curative-intent therapy.
Visual signals in the wing display of a tephritid fly deter jumping spider attacks
Authors: Rao Dinesh , Long Skye M. , Tapia-McClung Horacio , Salgado-Espinosa Kevin , Narendra Ajay , Aguilar-Arguello Samuel , Robledo-Ospina Luis , Rodriguez-Morales Dulce , Jakob Elizabeth M. 
Published: December 2022

ABSTRACT
Visual animal communication, whether to the same or to other species, is largely conducted through dynamic and colourful signals. For a signal to be effective, the signaller must capture and retain the attention of the receiver. Signal efficacy is also dependent on the sensory limitations of the receiver. However, most signalling studies consider movement and colour separately, resulting in a partial understanding of the signal in question. We explored the structure and function of predator–prey signalling in the jumping spider–tephritid fly system, where the prey performs a wing waving display that deters an attack from the predator. Using a custom-built spider retinal tracker combined with visual modelling, as well as behavioural assays, we studied the effect of fly wing movement and colour on the jumping spider's visual system. We show that jumping spiders track their prey less effectively during wing display and this can be attributed to a series of fluctuations in chromatic and achromatic contrasts arising from the wing movements. These results suggest that displaying flies deter spider attacks by manipulating the movement biases of the spider's visual system. Our results emphasise the importance of receiver attention on the evolution of interspecific communication.
Evaluation of vitamin D supplementation intake among children; cross-sectional observational study
Authors: Sharafi Niloufar , Fatima Aiman , Gillani Syed Wasif , Kaddour Nour , Banoori Rawa , Elshafie Riham Mohamed , Rathore Hassaan Anwer 
Published: December 2022

Background: The purpose of this study was to review the vitamin D supplementation intake status among children in the general public, determine the vitamin D supplements practices, and the barriers that parents and children face with supplementation. Methods: A cross-sectional observational questionnaire-based survey study design was used. A convenience sampling technique was used to collect the data. An online Rao soft sample size calculator was applied to determine the sample size of 319. The response rate of participants was expected to be 63%, the margin of error was 5% and the level of confidence was 95%. Results: A total of 248 parents (89.1% mothers (n =203)) and 15.7% fathers (n=39) with a mean ± SD age of 35.4 ± 7.04 years, completed the study (77.7% response rate). Parents reported that the supplements used the most by children were vitamin D supplements (21.85%) and multivitamins (21.8%) followed by calcium supplements (5.6%). However, 27.8% of children in this study did not take any supplements. Of all the parents, 65% (162) of them reported sending their child outside to play while 34.67% (86) of parents had reported no outdoor activity. Approximately 184 (74.2%) parents reported the child’s diet to contain multiple natural sources of vitamin D. However, 69 (27.8%) parents reported giving none of the natural sources of vitamin D to their children through the diet. Parents with higher education about 62.9% (n=156) had a higher frequency of providing vitamin D supplements to their children. Children in high-income families (43.63%) were more likely to take vitamin D supplements than those in middle- or low-income families. Conclusion: The study concluded that challenges like the educational and financial background of parents, family-income level, and health insurance status could help aid in addressing the overall burden of vitamin D deficiency among young children.
Sexual dimorphism in relationships between of plasma urea and some psycho-neuro-endocrine parameters
Authors: Bombushkar Igor , Anchev Anatoliy , Żukow Xawery , Popovych Igor 
Published: December 2022

Background. Earlier we found a strong urato-neural relationships in both men and women. Moreover, in women, the factor structure of the neural root is almost completely different from that in men. In addition, significant differences were found between the profiles of urato-neural correlations of women of reproductive age and postmenopausal women. The purpose of this study is to analyze the relationships between the plasma urea level and some psycho-neuro-endocrine parameters in the same cohort. Materials and Methods. The object of observation were almost healthy volunteers: 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). In basal conditions we determined plasma levels of urea and adaptation hormones, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By building regression models with stepwise exclusion, it was found that in men plasma urea positively determines (R2=0,499) the level of circulating catecholamines and power spectrum density (PSD) of δ-, θ- and β-rhythms in different loci. In postmenopausal women, urea downregulates the amplitude and PSD of δ-rhythm in different loci, instead, it upregulates the PSD of α-rhythm in T5 locus, entropy of EEG in 2 loci and vagal tone. The degree of determination of neural parameters is 71,6%. In women of reproductive age the degree of determination of neural parameters is similar (69,9%), but the factor structure of the model is completely different. Urea upregulates the PSD of β-rhythm in F7 locus while downregulates the levels of reactive anxiety, vagal tone, entropy of EEG in 3 loci and P4-θ PSD as well as causes left lateralization of θ- and α-rhythms. Conclusion. Plasma urea has a modulating effect on EEG&HRV parameters, as well as reactive anxiety, but this effect is significantly different in men and women of different ages.
Can preservice physical educators’ implicit attitude toward students with disabilities be changed by adapted physical education training program? Based on an Implicit Association Test
Authors: Li Yun , Tan Qinyi 
Published: December 2022

Purpose: Aim to explore whether preservice physical educators’ implicit attitude toward students with disabilities could be improved by a mid-term adapted physical education training program.
Design: A randomized and controlled trial was deployed in the current experiment. Subjects were randomly divided into two groups (Experimental group and control group) after the pre-test of IAT. Post-test IAT was conducted for two groups after the training program for the experimental group.
Findings: Chinese preservice physical educators’ implicit attitudes toward students with disabilities were negative. They also had a prejudice against students with disabilities. But the implicit attitudes toward students with disabilities could be improved by mid-term adapted physical education training. Furthermore, gender and contact experience with disabilities had no significant influence on the change in their implicit attitude.
Training on the utilization of banana pseudostems for manufacturing liquid organic fertilizer
Authors: Murnita Murnita , Afrida Afrida 
Published: December 2022

Tanjung Durian Pasar Baru village, Bayang subdistrict, Pesisir Selatan district is one of the location for the Students Community Service - Community Empowerment Learning Ekasakti University in 2019. This location is an agricultural area, one of the commodities is the banana plant. The habits of the farmers during this time, banana stems have been cut down are left to rot in the banana groves (waste). Even though banana stem can be used, one of which is for liquid organic fertilizer. Therefore this community service aims to; (1) to increase the farmer's motivation to make liquid organic fertilizer from the fake banana stem, (2) to improve the farmer's knowledge and skills about liquid organic fertilizer from the fake banana stem, and (3) to encourage the farmers to use liquid organic fertilizer from the fake banana stem, to reduce the use of inorganic fertilizer. In order to achieve this objective, the method used is counselling, practice, monitoring and evaluation. The results achieved show that community service activities are going well, and the community is eager to participate in the training and has a high desire to continue making POC, as seen from the activities of making POC which are carried out again by farmers. Farmers' knowledge increased about the understanding, advantages, disadvantages, benefits of POC and dexterity in making and using POC from fake banana stalks above 70%. The community implements the use of POC on peppers and tomatoes, thereby minimizing the use of inorganic fertilizers. In addition, POC can be marketed, thereby increasing farmers' income.
An online education program for improving parent’s knowledge of appropriate complementary feeding and child health
Authors: Widyaningrum Rachmawati , Wienarno Fredeswindra Elievia Chintyasningrum , Jamilah Nurul 
Published: December 2022

During the Covid-19 pandemic, its socio-economic impact can disrupt children's state of well-being as a vulnerable group. The changes in income and difficulties in accessing healthy and affordable food may affect the complementary feeding (CF) practices, and affect a child's nutritional status, and immunity. Besides, the lack of CF knowledge results in an increment in commercial supplement consumption to patch up nutrient deficiencies or prevent transmission. In this regard, the education program about healthy complementary feeding is essential. The online education program titled "Healthy Complementary Feeding to Protect Child's Health" was attended by 17 of 60 registrants (23,8%). It aimed to improve CF knowledge based on the WHO recommendation on CF, including local food-based CF The program's evaluation results show that the major of the participants were satisfied, 60% of them strongly agreed that it was informative, and 75% of them strongly agreed that the materials were easy to understand. The follow-up results of 14 participants show that the CF knowledge score increased by 10.5% (The before-after mean score). The topic of children refusing to eat was the most beneficial topic for participants (92.9%). The conclusion is that an online-based education program in the pandemic setting can increase the participant's CF knowledge.
Polarization-independent microchannel in a high-speed-scan femtosecond laser-assisted etching of fused silica
Authors: Yao Qian , Yin Weiyi , Yao Heng , Shi Huiqiang , Su Zihuai , Zeng Xianglong , Shi Xiaoning , Zhao Wancong , Dai Ye 
Published: December 2022

Microchannels fabricated by femtosecond laser-assisted chemical etching are of great
use in biochemical analysis. In this paper, we study the morphology
change of etched microchannels in fused silica by controlling the
laser scan speed, and we find a significant difference between the
chemical etched length and volume. The fabricated microchannels would
gradually become tapered along the scan direction, which influences
the flow of the hydrofluoric (HF) reagent and the etching rate. As a
result, the difference ratios of the etched length and volume,
respectively, reach

−

5.56

%

and

−

41.83

%

followed by the scan speed increasing
from 5 to 200 µm/s. Microchannels with polarization
independence and better aspect ratio could be obtained in a
high-speed-scan mode. We suggest that laser-induced structural
transformation from interconnected microcracks to nanogratings could
be responsible for this change. Aforementioned results offer a
feasible approach to achieve polarization-independent microchannels,
which is in favor of accelerating the fabrication of three-dimensional
microfluidic devices.