bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Resilience-Based Intervention to Mitigate the Effect of HIV-Related Stigma: Protocol for a Stepped Wedge Cluster Randomized Trial
Authors: Li Xiaoming , Qiao Shan , Yang Xueying , Harrison Sayward E. , Tam Cheuk Chi , Shen Zhiyong , Zhou Yuejiao 
Published: March 2022

BackgroundDespite decades of global efforts to tackle HIV-related stigma, previous interventions designed to reduce stigma have had limited effects that were typically in the small- to-moderate range. The knowledge gaps and challenges for combating HIV-related stigma are rooted both in the complexity of the stigma and in the limitations of current conceptualizations of stigma reduction efforts. Recent research has shown the promise of resilience-based approaches that focus on the development of strengths, competencies, resources, and capacities of people living with HIV (PLWH) and their key supporting systems (e.g., family members and healthcare providers) to prevent, reduce, and mitigate the negative effects of stigma. However, the resilience-based approach, while hypothesized, has rarely been empirically tested in large intervention trials, especially in resource-limited settings.MethodsIn this study, we propose to develop, implement, and evaluate a theory-guided, multilevel, multimodal resilience-based intervention via a stepped wedge cluster randomized trial among 800 PLWH and their biological or surrogate family members, as well as 320 healthcare providers in Guangxi, China with a longitudinal follow-up period of 36 months at 6-month intervals. The primary outcome will be viral suppression and the intermediate outcomes will include perceived stress and medication adherence of PLWH as well as resilience measures at the level of the individual, the family, and the healthcare system.DiscussionThe proposed study will be one of the first large scale efforts to examine whether resilience among PLWH can be fostered and sustained through a multilevel and multi-component HIV-related stigma intervention and whether a resilience-based intervention can improve clinical outcomes and quality of HIV care among PLWH in a low-resource setting. If efficacious, the intervention components could be tailored to other groups of PLWH and adapted for other low- and middle-income countries.Trial RegistrationThis trial is registered at ClinicalTrials.gov, registration number NCT05174936, registered 13 December 2021. https://register.clinicaltrials.gov/prs/app/action/LoginUser?ts=3&amp;cx=-jg9qo2.
Chemical Composition and Agronomic Traits of Allium sativum and Allium ampeloprasum Leaves and Bulbs and Their Action against Listeria monocytogenes and Other Food Pathogens
Authors: Polito Flavio , Amato Giuseppe , Caputo Lucia , De Feo Vincenzo , Fratianni Florinda , Candido Vincenzo , Nazzaro Filomena 
Published: March 2022

In this work, we aimed to study the chemical composition of the essential oils from bulbs and leaves of two cultivars of Allium sativum L. and two of A. ampeloprasum L. var. holmense. Moreover, we investigated their activity against four common bacterial strains responsible for food contamination (Listeria monocytogenes, Escherichia coli, Acinetobacter baumannii, and Staphylococcus aureus) by formation of biofilms. The susceptibility of bacterial biofilms was evaluated by crystal violet assay, whereas the metabolic changes occurring in the bacterial cells were ascertained through the MTT test. The essential oils were characterized by the presence of most characteristic components, although with different composition between the species and the cultivars. The essential oils inhibited the capacity of the pathogenic bacteria to form biofilms (up to 79.85 against L. monocytogenes) and/or acted on their cell metabolism (with inhibition of 68.57% and 68.89% against L. monocytogenes and S. aureus, respectively). The capacity of the essential oils to act against these foodborne bacteria could suggests further ideas for industrial applications and confirms the versatility of these essential oils as food preservatives.
IMPROVING OF SUBJECT-METHODOLOGICAL COMPETENCE OF FUTURE PHYSICAL CULTURE TEACHERS IN CONDITIONS OF BLENDED LEARNING
Authors: DANYSKO O. 
Published: March 2022

The article substantiates the theoretical and methodological principles of improving the subject-methodological competence of future physical culture teachers in conditions of blended learning. The issues of modernization of the domestic system of higher pedagogical education are considered, the problem of developing the trajectory of professional development of a teacher of a new Ukrainian school on the basis of the competence approach is actualized.
The essence and structure of the concept «subject-methodological competence of future physical culture teacher» are defined as the generalized purpose and result of his/her professional skills which are characterized by integration of theoretical knowledge on a specialty and orientation in modern concepts of physical culture and health-improving work organization; as well as the ability to select methods of rehabilitation and develop technologies to increase the level of physical activity of student youth; the skills of organizing partnerships with parents and colleagues in order to improve the quality of educational process on the subject of «Physical Culture».
The main directions of improving the subject-methodological competence of future physical culture teachers in conditions of blended learning are determined on the example of studying the discipline "Modern sports and health-improving technologies": at the organizational level – determining learning outcomes, selecting assessment strategies, designing courses, distinguishing the optimal part of face-to-face and online components; at the content level – structuring of materials (topics, tasks, program questions) that are professional in content and educational in form and provide contextual modelling of future physical culture and health-improving activities; at the procedural and technological level – the use of a set of tools and practices that contribute to the professional adaptation of the student to future activities and are provided with active methods (problem-based learning, discussion, analysis of educational situations, solving educational problems, gamification, creative individual work, modelling professional and methodological activities, etc.) and educational means (multimedia textbooks, interactive tasks); at the reflexive level – the use for educational and diagnostic purposes of various forms of answers: oral; written (graphic); using information and communication technologies.
Analisis Pendapatan, Produktivitas Dan Curahan Tenaga Kerja Usahatani Padi Sawah Pada Petani Pengguna Dan Bukan Pengguna Brigade Alsintan (Alat Dan Mesin Pertanian) Di Kecamatan Pabuaran, Kabupaten Subang
Authors: Arifin Andi , Dasipah Euis , Permana Nendah Siti 
Published: March 2022

This study aims to analyze the effect of using Alsintan (Agricultural Machine Tools) on income, productivity and outpouring of labor for lowland rice farming. This research uses survey method. The technique for determining respondents used the Taro Yamane formula (1967) and obtained a sample size of 41 respondents who were allocated proportionally, namely 23 farmer respondents who used agricultural machinery and 18 farmer respondents who did not use agricultural machinery. The results showed that the income of lowland rice farmers using agricultural machinery was different from the income of rice farmers who were not using agricultural machinery. The income of lowland rice farmers using agricultural machinery is Rp. 15,117,478, which is Rp. 7,855,255, - compared to the income of rice farmers who do not use machinery, which is only Rp. 7,262,223. The productivity of lowland rice farmers using agricultural machinery is different from that of farmers who are not using agricultural machinery, namely the productivity of lowland rice farmers using agricultural machinery is 6,825 kg/hectare/season, 771.0 kg higher than the productivity of paddy rice for farmers who do not use machinery, which is only 6,066 kg/hectare/season. The outpouring of labor for rice farmers using machine tools is different from the labor for rice farmers not using machine tools, where the labor for rice farmers using machine tools is 69 working days/hectare/season, 42 working days less than rice farmers not using machine tools which is 111 Working Days/hectare/season.
PENYALAHGUNAAN KEADAAN DALAM PERJANJIAN PENGIKATAN JUAL BELI APARTEMEN SEBAGAI PEMBATAS PEMENUHAN AZAS KESEIMBANGAN
Authors: Sari Dalimunthe Siti Nurul Intan 
Published: March 2022

Pelaksanaan jual beli apartemen banyak dilakukan dengan cara memesan terlebih dahulu unit apartemen yang akan dibeli yang dituangkan dalam Perjanjian Pengikatan Jual Beli (PPJB) sebagai pengikatan sementara, dikarenakan apartemen belum lunas, belum selesai dibangun, ataupun sertifikat yang belum pecah. Namun, dalam pelaksanannya, banyak PPJB apartemen yang menimbulkan wanprestasi di kemudian hari yang berujung pada gugatan yang dilakukan oleh pembeli (konsumen). Pada prakteknya, pembuatan PPJB Apartemen dibuat oleh salah satu pihak yaitu pihak pengembang, sehingga tidak terdapat keseimbangan kehendak dari para pihak. Perjanjian selain harus mememnuhi syarat-syarat sah perjanjian dalam Pasal 1320 KUHPerdata, juga harus memberlakukan asas-asas dalam perjanjian, salah satu asasnya keseimbangan. Tujuan dari penelitian ini adalah untuk mengetahui pemenuhan asas keseimbangan dalam PPJB apartemen. Penelitian ini menggunakan metode yuridis normatif dan pendekatan perundang-undangan dan pendekatan konseptual. Hasil dari penelitian ini, bahwa dalam PPJB Apartemen terdapat penyalahgunaan keadaan karena keunggulan ekonomi dari pihak pengembang terhadap pihak pembeli dimana isi perjanjian yang dibuat oleh pengembang hanya menguntungkan pihak pengembang yang posisi tawarnya lebih tinggi dan merugikan pembeli yang tidak ikut serta dalam menentukan isi perjanjian, sehingga tidak terpenuhinya asas keseimbangan dalam PPJB apartemen. Penentuan isi PPJB apartemen yang dilakukan secara sepihak oleh pihak pengembang, lebih banyak menguntungkan pengembang saja, sehingga menyebabkan sering terjadinya wanprestasi yang merugikan pihak pembeli dan menimbulkan gugatan dari pembeli di kemudian hari.
Comparison of ASP.NET Core and Spring Boot ecosystems
Authors: Rozaliuk Teofil , Kopyl Petro , Smołka Jakub 
Published: March 2022

The article describes a comparative analysis of the ASP.NET Core and Spring Boot framework ecosystems. The research was carried out on the basis of implemented two applications with identical functionality, which use the PostgreSQL database engine. In the implementation of the application, appropriate ORM tools were used to perform database operations, ie Spring Data and Entity Framework Core, technologies enabling the implementation of authentication and authorization (Spring Security and ASP.NET Core Identity) and several additional libraries that simplify the entire process of building the application. The criteria of comparison were the ease and intuitiveness of a given tool in the implementation of the application, the offered possibilities of the tools implementing authentication and authorization mechanisms, the efficiency of database operations, the general structure of the application and basic code metrics. Based on the research, it was found that Spring Data technology is a faster tool than Entity Framework Core, while Spring Security, unlike Asp.Net Core Identity, is less integrated into the framework ecosystem.
Feasibility of At-Home Vibrotactile Data Collection in Children and Adolescents: Study of Mild Traumatic Brain Injury
Authors: Stokoe Mehak , Bell Tiffany , Mauthner Micaela , O'Brien Heidi , Ip Amanda , Tommerdahl Mark , Yeates Keith , Harris Ashley 
Published: March 2022

Remote testing has become a desireable option as it helps reduce participant burden, can be more convenient and enables longitudinal data collection to track symptom recovery. Recently, advances in testing have enabled researchers to test somatosensory processing and brain function. Using tactile testing modalities such as vibrotactile stimulation to the fingertips can provide information about cortical inhibition, for example, without the need for invasive testing procedures. In the current manuscript, we present our initial experience for ‘at home’ tactile testing. We demonstrate 1) it is possible to develop an ‘at home’ testing battery with multiple tasks that is comparable to ‘in lab’ testing; and 2) it is feasible to collect this data remotely and repeatedly to monitor longitudinal changes.
Participants included pediatric concussion patients and orthopedic injury (OI) controls, 8-18 years of age at time of participation, and were recruited ~10 days after injury. Testing was conducted on a 2-digit vibrotactile stimulator hand-held device and was based on previously used protocols. Stimulation was delivered to the left index and middle finger. Data quality of tasks was visually inspected to ensure data followed a pattern of converging values of thresholds over time. A total of 19 participants were recruited in this study; 11 concussion and 8 OI. Participants in the concussion group were 12.8 ± 2.2 years old (36.4% female) and participants in the OI group were 11.6 ± 2.5 years old (57.1% female) at the time of injury. Results from paired sample t-tests comparing task performance did not detect significant differences between the data collected from the home session and at the lab visit for the concussion group.
Our results demonstrate that vibrotactile sensory testing can provide a non-invasive, objective measure of central nervous system functioning without relying on subjective questionnaires. This work demonstates it is possible to perform this testing remotely. Our data with children and adolescents demonstrates they are capable of completing these tasks at home; we therefore expect this at home testing protocol could easily be administered in other populations.
Gravitational-wave Emission from a Primordial Black Hole Inspiraling inside a Compact Star: A Novel Probe for Dense Matter Equation of State
Authors: Zou 邹 Ze-Cheng 泽城 , Huang 黄 Yong-Feng 永锋 
Published: March 2022

Abstract
Primordial black holes of planetary masses captured by compact stars are widely studied to constrain their composition fraction of dark matter. Such a capture may lead to an inspiral process and be detected through gravitational-wave signals. In this Letter, we study the postcapture inspiral process by considering two different kinds of compact stars, i.e., strange stars and neutron stars. The dynamical equations are numerically solved, and the gravitational-wave emission is calculated. It is found that the Advanced LIGO can detect the inspiraling of a 10−5
M
⊙ primordial black hole at a distance of 10 kpc, while a Jovian-mass case can even be detected at megaparsecs. Promisingly, the next generation of gravitational-wave detectors can detect cases of 10−5
M
⊙ primordial black holes up to ∼1Mpc and Jovian-mass cases at several hundred megaparsecs. Moreover, the kilohertz gravitational-wave signal shows significant differences for strange stars and neutron stars, potentially making it a novel probe to the dense matter equation of state.
The Turbulent Properties of the Sub-Alfvénic Solar Wind Measured by the Parker Solar Probe
Authors: Zhao L.-L. , Zank G. P. , Telloni D. , Stevens M. , Kasper J. C. , Bale S. D. 
Published: March 2022

Abstract
For the first time, Parker Solar Probe (PSP) observed the sub-Alfvénic solar wind where the solar wind bulk speed drops below the local Alfvén speed for an extended period of time. Here, we report on the turbulent properties of the sub-Alfvénic region. We analyze the turbulence correlation length and the energy transfer and compare the results with nearby super-Alfvénic regions. As the Alfvén speed is larger or comparable to the solar wind speed in the intervals studied, we use a modified Taylor’s hypothesis to account for wave propagation. We find that the wave propagation speed affects the analysis of the correlation lengths of the forward and backward propagating
z

± modes. In the sub-Alfvénic region, the correlation length of the
z

− mode is shorter than that of the outward propagating
z

+ mode, although the correlation time of the
z

− mode is about 10 times larger than that of the
z

+ mode. For the energy transfer, we use both incompressible and compressible formulations to calculate the energy flux based on third-order structure functions. The incompressible energy cascade rates for the forward and backward propagating modes are computed separately using the modified Taylor’s hypothesis. The averaged compressible cascade rate is higher in the sub-Alfvénic interval than the nearby downstream super-Alfvénic region, which may be due to the lower fluctuation amplitude in the latter super-Alfvénic interval. Longer incursions of the PSP in the sub-Alfvénic winds in the future will give us better statistics.
Xiaochaihu Decoction in Diabetic Kidney Disease: A Study based on Network Pharmacology and Molecular Docking Technology
Authors: Wang Ying , Zhou Xuefeng , Luo Minjing , Zhao Tingting , Li Ping 
Published: March 2022

Abstract

Objective:
To explore the potential mechanism of Xiaochaihu decoction (XCHD) in the treatment of diabetic kidney disease (DKD) by network pharmacology and molecular docking technology.

Materials and Methods:
Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was used to screen out main active components of XCHD. Gene names of target proteins were obtained with UniProt database. DKD targets were collected by GeneCard database, and common targets were selected through jvenn platform. STRING database was used to construct a protein-protein interaction network. Enrichment analysis was carried out through the Metascape platform. The “drug-component-target” and “component-target-KEGG pathway” networks were constructed using Cytoscape software. Molecular docking analysis was carried out with AutoDockTool software.

Results:
A total of 195 active components were obtained for XCHD. There were 238 corresponding targets and 128 common targets associated with DKD, and the core targets involved IL6, AKT1, VEGFA, TNF, TP53, PTGS2, and JUN. Gene ontology enrichment analysis revealed 2242 entries for biological processes, 82 entries for cellular components, and 166 items of molecular functions. A total of 333 signal pathways were screened by KEGG pathway enrichment analysis. Molecular docking showed that quercetin, baicalin, luteolin, and wogonin were tightly bound to the key target proteins of PTGS2 and AKT1.

Conclusions:
195 active components were screened from XCHD, among which 128 intersections with DKD were identified, and 333 signaling pathways were identified by KEGG pathway enrichment analysis. The key active components in XCHD, such as quercetin, baicalin, luteolin and wogonin, regulate multiple signaling pathways by acting on PTGS2, AKT1 and other targets, for anti-inflammatory, antioxidant, regulating cell factors, improving insulin resistance, and protecting renal function. This study provides a more in-depth scientific basis and research direction for the investigation on XCHD treatment of DKD.
Tangshen Formula Attenuates Renal Fibrosis by Downregulating Transforming Growth Factor β1/Smad3 and LncRNA-MEG3 in Rats with Diabetic Kidney Disease
Authors: Zhou Xue-Feng , Wang Ying , Luo Min-Jing , Zhao Ting-Ting , Li Ping 
Published: March 2022

Abstract

Background and Objective:
The traditional Chinese Tangshen formula (TSF) has been reported to ameliorate diabetic kidney disease (DKD) in humans and animals. However, the effect of TSF on renal fibrosis remains unclear. Transforming growth factor-β1 (TGF-β1)/Smad3 signaling and lncRNA MEG3 are important in renal fibrosis. In this study, we examined the therapeutic effect of TSF on renal fibrosis and explored whether it was related to the modulation of TGFβ1/Smad3 signaling and lncRNA MEG3 expression.

Materials and Methods:
Experiments were performed in rats in vivo and in the HK2 cells in vitro. DKD was induced in rats by uninephrectomy combined with a single streptozotocin injection. The HK2 cells were stimulated by high glucose (HG) to explore the mechanism of TSF effects in vitro.

Results:
TSF significantly attenuated renal injury by lowering proteinuria and renal histological damage in DKD rats. TSF reduced collagen deposition by decreasing the expression of the fibrotic indicators collagen I, collagen IV, and fibronectin at the protein and mRNA levels, which suggested that TSF ameliorated DKD by decreasing renal fibrosis. Furthermore, TSF decreased TGF-β1 expression and suppressed the levels of phosphorylated Smad3 and Smad2/3 in vivo. Moreover, TSF downregulated the lncRNA MEG3 level in DKD rats. TSF reversed the upregulation of collagen I and fibronectin expression and downregulated Smad2/3 phosphorylation in the HK2 cells stimulated with HG.

Conclusions:
TSF ameliorates renal fibrosis in rats with DKD by suppressing TGF-β1/Smad3 signaling and lncRNA MEG3 expression.
Comité de seguridad del paciente: creado y liderado por instrumentadores quirurgicos
Authors: Gallo Silvana 
Published: March 2022

La experiencia que se presenta, proviene de uno de los 33 hospitales públicos del Gobierno de la Ciudad de Buenos Aires, convocados a capacitarse en la temática de Seguridad del Paciente, describe la iniciativa y gestión de los Instrumentadores Quirúrgicos, quiénes no suelen ocupar posiciones centrales de liderazgo en Comités o Auditorías relacionadas al tema en la República Argentina. La Seguridad del Paciente forma parte de la gestión de calidad en salud. No existe calidad sin seguridad del paciente y dicha gestión se basa en el cumplimiento de estándares planificados y conducidos por líderes formados en el tema. La gestión de calidad se enriquece y toma fluidez al tomar en cuenta el importante concepto de “calidad con calidez”. La necesidad de alcanzar las metas internacionales de seguridad del paciente, es disparadora de una gestión multidisciplinaria, a fin de adaptar las organizaciones a una nueva cultura de seguridad. Si bien dicha necesidad es especialmente visible en la gestión privada, abrir y plantear la cultura de seguridad del paciente en las instituciones públicas, requiere de una gestión delineada por procesos administrativos complejos, el consenso de múltiples sectores con criterios amparados constantemente en limitaciones por carencias de recursos, en algunos casos influenciados por mitos y el crecimiento se ve parcialmente condicionado por el momento político vigente. El foco más importante sigue estando en la capacitación, como en todas las instancias de instrucción de las profesiones relacionadas a la medicina, siendo este factor el mayor consumidor de tiempo que condiciona la disponibilidad a trabajar en el diseño de guías de práctica clínica, protocolos, normas de procedimiento, el reporte de eventos adversos, y trigger tools. Es importante analizar la formación de los líderes, sus iniciativas y perseverancia. Ellos encuentran como gran dificultad la falta de tiempo protegido para asistir a entrenamientos en el horario de trabajo y les resulta muy difícil, reservar un espacio para capacitarse. En lineas generales esto se debe al pluriempleo. La creación y progreso de un Comité que llegue a implementar las medidas en un hospital, forman parte de la iniciativa de la Dirección y su traslado a los distintos jefes de Departamento siempre siguiendo una línea jerárquica. Seguridad del paciente, es además una disciplina de incumbencia del Comité de Calidad. La situación que presenta este artículo, se llevó a cabo invirtiendo todos estos códigos de trabajo.