bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mean-field formulation for mean-variance asset-liability management with cash flow under an uncertain exit time
Authors: Liu Wei , Sun Youfa , Chen Xu 
Published: February 2022

Abstract
The asset-liability management problem with cash flow under an uncertain exit time has been investigated in this article, which is based on the fundamental framework of the mean-variance model in the multi-period version. The liability and random cash flow will affect asset optimization, while the investor may be forced to withdraw from investments with a random probability at each period in our model. The closed-form expressions for the mean-variance optimal portfolio selection and its corresponding efficient frontier are obtained by employing the mean-field formulation and dynamic programming approach. Moreover, some numerical examples are provided to illustrate the validity and accuracy of the theoretical results.
A high order weak approximation for jump-diffusions using Malliavin calculus and operator splitting
Authors: Akiyama Naho , Yamada Toshihiro 
Published: February 2022

AbstractThe paper introduces a novel high order discretization scheme for expectation of jump-diffusion processes by using a Malliavin calculus approach and an operator splitting method. The test function of the target expectation is assumed to be only Lipschitz continuous in order to apply the method to financial problems. Then Kusuoka’s estimate is employed to justify the proposed discretization scheme. The algorithm with a numerical example is shown for implementation.
Smurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2
Authors: Song Dongqiang , Li Shuyu , Ning Liuxin , Zhang Shuncai , Cai Yu 
Published: February 2022

Abstract

Purpose
Smurf2, one of C2-WW-HECT domain E3 ubiquitin ligases, is closely related to the development and progression in different cancer types, including hepatocellular carcinoma (HCC). This study aims to illustrate the expression and molecular mechanism of Smurf2 in regulating the progression of HCC.

Methods
The expression of Smurf2 in human HCC and adjacent non-tumor liver specimens was detected using tissue microarray studies from 220 HCC patients who underwent curative resection. The relationships of Smurf2 and HCC progression and survival were analyzed using the chi-square test, Kaplan–Meier analysis, and Cox proportional hazards model. For Smurf2 was low expression in HCC cell lines, Smurf2 overexpression cell lines were established. The effect of Smurf2 on cell proliferation and migration was detected by Cell Counting Kit-8 and colony formation assay, and the epithelial–mesenchymal transition (EMT) markers and its transcription factors were tested by immunoblotting. The interaction and ubiquitination of Smad2 by Smurf2 were detected by co-immunoprecipitation and immunoprecipitation assay. Finally, the effect of Smurf2 on HCC was verified using the mouse lung metastasis model.

Results
Smurf2 was downregulated in HCC tissues compared to that of corresponding non-tumor liver specimens. The low expression of Smurf2 in HCC was significantly associated with macrovascular or microvascular tumor thrombus and the impairment of overall survival and disease-free survival. In vitro and in vivo analysis showed that Smurf2 overexpression decreased the EMT potential of HCC cells by promoting the ubiquitination of Smad2 via the proteasome-dependent degradation pathway.

Conclusion
The expression of Smurf2 was downregulated in HCC specimens and affected the survival of patients. Smurf2 inhibited the EMT of HCC by enhancing Smad2 ubiquitin-dependent proteasome degradation.
Asymptomatic and pre-symptomatic infection in Coronavirus Disease 2019 pandemic
Authors: Wang Yutong , Zheng Ke , Gao Wenjing , Lv Jun , Yu Canqing , Wang Lan , Wang Zijun , Wang Bo , Liao Chunxiao , Li Liming 
Published: February 2022

AbstractWith the presence of Coronavirus Disease 2019 (COVID-19) asymptomatic infections detected, their proportion, transmission potential, and other aspects such as immunity and related emerging challenges have attracted people’s attention. We have found that based on high-quality research, asymptomatic infections account for at least one-third of the total cases, whereas based on systematic review and meta-analysis, the proportion is about one-fifth. Evaluating the true transmission potential of asymptomatic cases is difficult but critical, since it may affect national policies in response to COVID-19. We have summarized the current evidence and found, compared with symptomatic cases, the transmission capacity of asymptomatic individuals is weaker, even though they have similar viral load and relatively short virus shedding duration. As the outbreak progresses, asymptomatic infections have also been found to develop long COVID-19. In addition, the role of asymptomatic infection in COVID-19 remains to be further revealed as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to emerge. Nevertheless, as asymptomatic infections transmit the SARS-CoV-2 virus silently, they still pose a substantial threat to public health. Therefore, it is essential to conduct screening to obtain more knowledge about the asymptomatic infections and to detect them as soon as possible; meanwhile, management of them is also a key point in the fight against COVID-19 community transmission. The different management of asymptomatic infections in various countries are compared and the experience in China is displayed in detail.
Design check of cyclically loaded weld seams
Authors: Rudolph Jürgen , Weiß Eckart 
Published: February 2022

Abstract
This paper discusses the design check of cyclically loaded weld seams with improved fatigue performance due to post weld treatment operations such as TIG dressing and grinding. The algorithm is mainly based on the local strain approach to design against fatigue. It accounts for the fundamentally different damage process and conceptual consequences of weld seams with post weld treatment compared to the usual approach based on nominal, structural or notch stresses.
Temperaturverteilung und temperaturbedingte Spannungen beim Warmwalzen
Authors: Goryany Vyacheslav , Beuke Thilo 
Published: February 2022

Abstract
Der vorliegende Beitrag gibt einen analytischen Überblick über die Hauptergebnisse der experimentellen und theoretischen Untersuchungen zu den Temperaturen und Spannungen, die in der Arbeitsschicht der Walzen beim Warmwalzen entstehen, und über die Ursachen der thermischen Beschädigung ihrer Oberfläche im Verlauf des Betriebes.
Topological optical parametric oscillation
Authors: Roy Arkadev , Parto Midya , Nehra Rajveer , Leefmans Christian , Marandi Alireza 
Published: February 2022

Abstract
Topological insulators possess protected boundary states which are robust against disorders and have immense implications in both fermionic and bosonic systems. Harnessing these topological effects in nonequilibrium scenarios is highly desirable and has led to the development of topological lasers. The topologically protected boundary states usually lie within the bulk bandgap, and selectively exciting them without inducing instability in the bulk modes of bosonic systems is challenging. Here, we consider topological parametrically driven nonlinear resonator arrays that possess complex eigenvalues only in the edge modes in spite of the uniform pumping. We show parametric oscillation occurs in the topological boundary modes of one and two dimensional systems as well as in the corner modes of a higher order topological insulator system. Furthermore, we demonstrate squeezing dynamics below the oscillation threshold, where the quantum properties of the topological edge modes are robust against certain disorders. Our work sheds light on the dynamics of weakly nonlinear topological systems driven out-of-equilibrium and reveals their intriguing behavior in the quantum regime.
The crystal structure of hexaquamagnesium(II) (2,4-bis(nitroimino)-6-oxo-1,3,5-triazinane-1,3-diide), C3H15MgN7O12
Authors: Tong Zhang , Guangyuan Zhang , Zishuai Xu , Jian Ruan , Lizhen Chen , Jianlong Wang 
Published: February 2022

Abstract
C3H15MgN7O12, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 6.7755(2) Å, b = 9.8181(3) Å, c = 11.0775(4) Å, α = 87.717(1)°, β = 78.297(1)°, γ = 70.804(1)°, V = 681.18(4) Å3, Z = 2, R

gt
(F) = 0.0382, wR

ref
(F
2) = 0.1083, T = 150 K.
Formulation of polymeric nanoparticles loaded sorafenib; evaluation of cytotoxicity, molecular evaluation, and gene expression studies in lung and breast cancer cell lines
Authors: Abdellatif Ahmed A. H. , Ali Asmaa T. , Bouazzaoui Abdellatif , Alsharidah Mansour , Al Rugaie Osamah , Tolba Nahla Sameh 
Published: February 2022

Abstract
Sorafenib (SFB) is an anticancer drug with sparingly water solubility and reduced bioavailability. Nanoformulation of SFB can increase its dissolution rate and solubility. The current study aimed to formulate SFB in nanoparticles to improve their solubility. The sorafenib nanoparticles (SFB-PNs) were synthesized using the solvent evaporation method, then evaluated for their particle size, polydispersity index (PDI), zeta-potential, morphological structure, and entrapment efficiency (EE%). Further, the anticancer efficacy in A549 and Michigan Cancer Foundation-7 (MCF-7) cancer cell lines was evaluated. The SFB-NPs were uniform in size, which have 389.7 ± 16.49 nm, PDI of 0.703 ± 0.12, and zeta-potential of −13.5 ± 12.1 mV, whereas transmission electron microscopy showed a well-identified spherical particle. The EE% was found to be 73.7 ± 0.8%. SFB-NPs inhibited the cell growth by 50% after 48 h incubation, with IC50 of 2.26 and 1.28 µg/mL in A549 and MCF-7, respectively. Additionally, SFB-NPs showed a significant decrease (P < 0.05) in p21, and stathmin-1 gene expression levels in both cell lines. Moreover, SFB-NPs showed a significant increase in DNA damage of 25.50 and 26.75% in A549 and MCF-7, respectively. The results indicate that SFB-NPs are a potential candidate with an effective anticancer agent compared with free drugs.
Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs
Authors: Kaur Manmeet , Kaur Mandeep , Bandopadhyay Tania , Sharma Aditi , Priya Anu , Singh Arvind , Banerjee Bubun 
Published: February 2022

Abstract
This chapter describes the importance and activity of a huge number of commercially available naturally occurring, natural product derived or synthetic heterocyclic anti-cancer drugs.
Common fixed point results via simulation type functions in non-Archimedean modular metric spaces and applications
Authors: Öztürk Mahpeyker , Girgin Ekber 
Published: February 2022

Abstract
In this study, we demonstrate the existence and uniqueness of common fixed points of a generalized (α,β)− simulation contraction on a non-Archimedean modular metric space. We achieve some consequences in non-Archimedean modular metric spaces as an application, using the structure of a directed graph. Eventually, we contemplate the existence of solutions to a class of functional equations standing up dynamic programming with the help of our outcomes.
Ear cupping in EFL classroom interaction: an embodied means of pursuing students’ response
Authors: Amar Cheikhna 
Published: February 2022

Abstract
This paper describes one of the embodied resources language teachers use to pursue a response from students: placing one hand behind the ear in an Ear Cupping (EC) gesture. The data analyzed are taken from over 20 h of English as a Foreign Language (EFL) classroom interaction video-recorded at a Japanese university. The paper explores how teachers use EC to pursue a response in cases when a Second-Pair Part (SPP) contribution from the student(s) is sequentially and temporally delayed, missing or inapposite. The findings suggest that the use of the EC gesture to pursue a response demonstrates the teachers’ orientation toward a normative understanding that a question posed within the classroom should be answered, even when a specific respondent has not been nominated. The analysis therefore reveals that the gesture constitutes an embodied means of monitoring intersubjectivity and increasing engagement in large groups of language learners.
Exploration of an unconventional validation tool to investigate aero engine transonic fan flutter signature
Authors: Viswanatha Rao A.N. , Satish T.N. , Naidu V.P.S. , Jana Soumendu 
Published: February 2022

Abstract
Flutter, an aeroelastic blade vibration phenomena, experienced by the fan of an developmental aero gas turbine engine, result in blade failure. Hence, suitable flutter detection instrumentation is required during engine testing. Flutter signature capture from revolving blades is a challenging task that necessitates either a complicated strain gauge-based rotating instrumentation or a noncontact tip timing system. Authors investigated a unique way for identifying, measuring, and validating flutter signature by assessing wall static pressure pulsations produced during blade tip transit across a casing mounted high bandwidth sensor during this research. The authors devised a mathematical model to explain signal spectrum components that feature both amplitude and angle modulation properties at the same time. The theory was tested using first-stage fan rotor blades that were fluttering in the first flexural mode (1F) and forming the second nodal diameter (2ND). The approach’s estimated blade deflection was compared to measurements taken using a traditional tip timing method up to 7 mm and determined to be within 1% inaccuracy. This research provides a low-cost, easy alternative technique for measuring flutter during engine development testing.
RE
3Rh2Sn4 (RE = Y, Gd–Tm, Lu) – first stannides with Lu3Co2In4 type structure
Authors: Schumacher Lars , Engelbert Simon , Klenner Steffen , Matar Samir F. , Pöttgen Rainer 
Published: February 2022

Abstract
The stannides RE
3Rh2Sn4 (RE = Y, Gd–Tm, Lu) were synthesized from the elements by arc-melting and subsequent annealing (1220 K for RE = Y, Gd–Tm and 1170 K for RE = Lu) in sealed silica ampoules for 11 days. X-ray powder diffraction studies confirm the hexagonal Lu3Co2In4 type structure, space group

P

6
‾

$P\overline{6}$

. The structure of Gd3Rh2Sn4 was refined from single crystal X-ray diffractometer data for a twinned crystal: a = 744.04(6), c = 409.23(4) pm, wR2 = 0.0288, 567 F
2 values and 21 variables. The RE
3Rh2Sn4 stannides derive from the well-known equiatomic stannides RERhSn (≍RE
3Rh3Sn3) by Rh/Sn ordering within the RE
6 trigonal prisms. The striking structural motif is the trigonal planar tin coordination of the Sn2 atoms with 288 pm Sn2–Sn1 distances. The Sn2 atoms carry substantially more negative charge than the Sn1 atoms. This is underlined by 119Sn isomer shifts of δ = 1.86(1) mm s−1 for Sn1 and δ = 2.26(1) mm s−1 for Sn2 detected in the Mössbauer spectrum of Lu3Rh2Sn4. From atoms in molecules (AIM) analysis of the charge density obtained with calculation based on density functional theory (DFT) for Y3Rh2Sn4, the charge transfer proceeds from yttrium towards more electronegative rhodium. Little departure from neutrality is observed for tin whose itinerant s-like states are little involved with the bonding. The site projected density of states (DOS) and the crystal orbital overlap population (COOP) plots further illustrate these observations and reveal major Y–Rh and Rh–Sn bonding, while Y–Sn bonding is weaker.
Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities
Authors: Antika Lucia Dwi , Tasfiyati Aprilia Nur , Hikmat Hikmat , Septama Abdi Wira 
Published: February 2022

Abstract
Scopoletin, also known as 6-methoxy-7 hydroxycoumarin, is one of the naturally occurring coumarin commonly found in many edible plants and plays an important role in human health. Despite the various potential pharmacological properties, the biosynthesis process, method of extraction, and mechanism of action on this compound have not been documented well. In this current review, the biosynthesis pathway, distribution of scopoletin in the plant kingdom, and extraction techniques are elaborated. The in vitro, in vivo, and in silico pharmacological studies are also discussed on antioxidant, antimicrobial, anticancer, anti-inflammation, and neuroprotective aspects of scopoletin. This study may help to understand the benefit of scopoletin containing plants and would be beneficial for the prevention and treatment of diseases.
Green and eco-friendly synthesis of TiO2 nanoparticles and their application for removal of cadmium from wastewater: reaction kinetics study
Authors: Irshad Muhammad Atif , Shakoor Muhammad Bilal , Nawaz Rab , Yasmeen Tahira , Arif Muhammad Saleem , Rizwan Muhammad , Rehman Muhammad Zia ur , Ahmad Sajid Rashid , Latif Maria , Nasim Iqra , Ali Shafaqat 
Published: February 2022

Abstract
The heavy metal cadmium (Cd) is known to be a widespread environmental contaminant and a potential toxin that may adversely affect human health across the globe. Green nanotechnology has recently received a lot of attention for developing eco-friendly, low-cost renewable and sustainable materials for the efficient removal of persistent contaminants from wastewater, including heavy metals (HMs). The current study compared the ability of titanium dioxide nanoparticles (TiO2 NPs) synthesized from Trianthema portulacastrum (A) and Chenopodium quinoa (B) extracts to remove Cd from wastewater. The washed biomass of both the plants was dried under shade for a few days and was ground into the fine particles in a blender. The powdered biomass of T. portulacastrum and C. quinoa was soaked separately in distilled water (@ 10 g/100 ml) for 36 h. The stock solution of titanium (0.3 M) was prepared from concentrated titanium tetraisopropoxide (TTIP) and was mixed with the plant extracts at 1:2 ratio of extract to TTIP solution with continuous stirring at room temperature. A light brown scum like TiO2-NPs were obtained at the bottom of china dish and calcined at 450 °C for 4 h. Finally, after natural cooling, the TiO2-NPs were collected and used for the sorption of Cd through wastewater. Sorption attributes of both TiO2 NPs (A, B) were investigated over contact time, dosage of adsorbent, pH, and initial concentration of Cd. Maximum sorption was obtained (46 mgg−1) by TiO2 NPs (A), followed by 44 mg Cd g−1 with TiO2 NPs (B) at pH 4.2, an optimum adsorbent dosage 0.7 g L−1, Cd initial level 30 mg L−1, with contact time of 2 h. Pseudo-second-order kinetic model was suited for adsorption experimental data using both nanoparticles. These results validated the potential use of TiO2 NPs to remove liquified cadmium at high concentrations from the industrial wastewater.
Nonadherence to Medical Treatment
Authors: Everhart Robin S. , Fiese Barbara H. 
Published: February 2022

Key Points
Nonadherence to recommended health-related treatment (eg, taking medications as prescribed; keeping appointments; following guidelines for seat belt use, exercise, sleep) in pediatrics occurs about 50% of the time and leads to significant morbidity and mortality.Barriers to adherence include parent and child mental health problems.Depressive symptoms or anxiety (child or parent); resultant lack of motivation, concentration, or desire to adhere to treatment regimensOppositional child behaviorsAdolescent risk-taking behaviorsFamily conflict or disengagementParents who are stressed, overwhelmed, and unable to set routines around treatment adherence or prioritize daily adherenceScreen children with chronic medical conditions for mental health concerns and incorporate a brief discussion of parent mental health and child mental health into each clinic session.Pediatric management of nonadherence includes using motivational interviewing and other "common factors" techniques toAddress barriers to adherence identified through history, screening, and clinical observations.Collaborate with patient and family to select strategies for improving adherence aligned with their intrinsic motivation.Provide referrals for adult or child psychological services and/or family-focused therapy, as needed.
El Programa de Fertilizantes para el Bienestar y el mercado de frijol en México
Authors: Borja-Bravo Mercedes , García-Salazar José Alberto 
Published: February 2022

Introducción. El Programa de Fertilizantes para el Bienestar se implementó en México a partir de 2019 y busca aumentar la productividad de cultivos básicos, entre ellos el frijol. Objetivo. Medir los efectos del Programa de Fertilizantes para el Bienestar en el mercado de frijol en México, el beneficio económico que generará en la sociedad y su contribución a la autosuficiencia alimentaria del grano. Materiales y Métodos. Se formuló y validó un modelo de equilibrio espacial que consideró las regiones productoras y consumidoras de frijol en México, se usó información en el año promedio 2017-2019. Resultados. Los resultados indicaron que la producción y el consumo nacional de frijol aumentarían en 228 y 79 miles de t, si el Programa de Fertilizantes para el Bienestar beneficiara a todos los productores de frijol; lo anterior significaría un aumento de 22,1 % en la producción que permitiría bajar las importaciones a cero. El Programa de Fertilizantes para el Bienestar ha promovido una mayor producción de frijol y ha contibuido a la autosuficiencia alimentaria al eliminar las importaciones, además de que generaría beneficios económicos para la sociedad, ya que los excedentes al productor y al consumidor aumentarían en USD$ 429 millones y USD$ 226 millones. Conclusión. El Programa de Fertilizantes para el Bienestar favoreció el crecmimiento de la producción e incentivó el consumo de frijol en México y desincentivó las importaciones de grano; esta acción incrementó la productividad de frijol y contribuyó con la autosuficiencia alimentaria.
Comparison of hamstring quadriceps strength ratios in different combat sports branches
Authors: Tatlıcı Ali , Löklüoğlu Berkay 
Published: February 2022

Background and Study Aim. The hamstring and quadriceps muscles can have strength differences because of the sportive activities. It is known that sportive hamstring quadriceps strength imbalance can cause decreasing sportive performance and injuries. Also, each sports branch can have a specific effect on the hamstring quadriceps strength ratio. Therefore, the aim of this study was to examine the effects of different combat sports branches on the hamstring quadriceps ratio.
Material and Methods. Wrestlers (N=10), boxers (N=10), wushu athletes (N=10) voluntarily participated in the study (also university students). Subjects were administered standard warm-up and then a strength measurement test was performed. Subjects performed knee extensor (quadriceps) and flexor (hamstring) isokinetic strength test (concentrically) with his dominant leg at 60° angular velocity with by Cybex device (Cybex NORM®. Humac. CA. USA). Peak and average strength were recorded automatically by the device. The SPSS package program was used in the analysis of the data. The isokinetic strength measurements of three groups were analyzed with one-way ANOVA.
Results. There were no significant differences between groups’ peak isokinetic strength ratio (wrestlers 0.58±0.09 boxers 0.56±0.07 and wushu athletes 0.57±0.12). Also, the average isokinetic strength ratio was not significantly different (wrestlers 0.56±0.08. boxers 0.60±0.08 and wushu athletes 0.53±0.11).
Conclusions. According to the results, it can be said that combat sports athletes' hamstring quadriceps ratio can be affected by their sports branches, also by characteristics and training levels.