bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late-time cosmology with phantom dark-energy in f(Q) gravity
Authors: Lymperis Andreas 
Published: November 2022

AbstractMotivated by the exciting features and a recent proposed general form of the function of non-metricity scalar Q, we investigate the cosmological implications inf(Q) gravity, through the resulting effective dark energy sector, extracting analytical expressions for the dark energy density, equation-of-state and the deceleration parameters. We show that even in the absence of a cosmological constant, the universe exhibits the usual thermal history, with the sequence of matter and dark energy eras, and the dark-energy equation-of-state parameter always lie in the phantom regime. Additionally, calculating the age of the universe, through the extracted analytical equations of the scenario at hand, we show that the result coincide with the value corresponding to ΛCDM scenario within 1σ. Moreover, we show the excellent agreement of the scenario at hand with Supernovae type Ia observational data. Lastly, comparing the cosmological behavior in the case of the absence of an explicit cosmological constant, with the one of the presence of a cosmological constant we show thatf(Q) gravity can mimic the cosmological constant in a very efficient way, providing very similar behavior, revealing the advantages and capabilitites of the scenario at hand.
Next-to-leading-order QCD corrections to gluon fragmentation into

quarkonia*
Authors: Feng Feng , Jia Yu 
Published: November 2022

Abstract
Within the NRQCD factorization framework, we compute the next-to-leading-order QCD corrections to the gluon fragmentation into the

Fock components of a quarkonium, at the lowest order in velocity expansion. We follow the operator definition of the fragmentation function advanced by Collins and Soper. The key technique underpinning our calculation is the sector decomposition method widely used in the area of multi-loop computation. It is found that the NLO QCD corrections have significant effects, and qualitatively modify the profiles of the corresponding leading-order fragmentation functions.
Characteristics of electron temperature profile stiffness in electron-heated plasmas on EAST
Authors: Liu J.W. , Zang Q. , Liang Y. , Huang Y.H. , Li E.Z. , Xu L.Q. , Knieps A. , Chu Y.Q. , Chao Y. , Hu Y.C. , Jin Y.F. , Liu H.Q. , Zhao H.L. , Lyu B. , Gong X.Z. , the EAST Team  
Published: November 2022

Abstract
A very high core electron temperature (T
e0 ∼ 10 keV) plasma has been established and stably sustained by applying both lower hybrid wave (LHW) and on-axis electron cyclotron resonance heating (ECRH) in the Experimental Advanced Superconducting Tokamak (EAST). In this work, power balance analysis shows that the increase of ECRH power can increase the normalized T
e gradient significantly at the plasma core region (ρ < 0.6), but does not change the T
e profile stiffness in the low-density L-mode plasmas. This has been considered to be due to a strong synergistic effect between ECRH and LHW. Furthermore, three distinguishable stages characterized by different T
e profile stiffnesses can be identified from the density ramp-up in the electron-heated plasma on EAST. A stronger T
e profile stiffness at ρ = 0.3 has been observed in the Stage-II, where the LHW power deposition gradually moves away from the plasma core region, following the electron density increases. Furthermore, the formation of an internal plasma density transport barrier inside ρ ∼ 0.6, accompanied by a sudden drop in core T
e and a rise in both core plasma density and ion temperature, has been observed for the first time during the transition from the Stage-II to the Stage-III when the central line-averaged plasma density reaches a threshold of 2.2 × 1019 m−3. This finding strongly affects further development of high-performance gas-fueled electron-heated plasma scenarios in EAST and suggests an advanced operational regime with a wide internal plasma density transport barrier.
Proxy Variables and the Generalizability of Study Results
Authors: Nilsson Anton , Björk Jonas , Bonander Carl 
Published: November 2022

AbstractWhen individuals self-select (or are selected) into a study based on factors that influence the outcome, conclusions may not generalize to the full population. To compensate for this, results may be adjusted, for example, by standardization on the set of common causes of participation and outcome. Although such standardization is useful in some contexts, the common causes of participation and outcome may in practice not be fully observed. Instead, the researcher may have access to one or several variables related to the common causes, that is, to proxies for the common causes. This article defines and examines different types of proxy variables and shows how these can be used to obtain generalizable study results. First of all, the researcher may exploit proxies that influence only participation or outcome but which still allow for perfect generalizability by rendering participation and outcome conditionally independent. Further, generalizability can be achieved by leveraging 2 proxies, one of which is allowed to influence participation and one of which is allowed to influence the outcome, even if participation and outcome do not become independent conditional on these. Finally, approximate generalizability may be obtained by exploiting a single proxy that does not itself influence participation or outcome.
Characterization of a xylanase belonging to the glycoside hydrolase family 5 subfamily 35 from Paenibacillus sp. H2C
Authors: Hagiwara Yusuke , Okeda Tomohiro , Okuda Keiko , Yatsunami Rie , Nakamura Satoshi 
Published: November 2022

ABSTRACT
Corn xylan is resistant to enzymatic hydrolysis due to its complex structure. We characterized PsXyn5A, an enzyme highly active for corn xylan, isolated from Paenibacillus sp. H2C. PsXyn5A is a modular xylanase with a catalytic domain belonging to the glycoside hydrolase family 5 subfamily 35 (GH5_35) and a carbohydrate-binding module family 13 (CBM13) domain. The substrate recognition mechanism of GH5_35 xylanase has not been reported. Analysis of the hydrolysate from rye arabinoxylan (RAX) has shown that the GH5_35 catalytic domain of PsXyn5A recognizes an arabinofuranosyl (Araf) side residue and cleaves the reducing terminal side of Araf-linked xylopyranose. This cleavage specificity is the same as reported for the GH5_34 xylanase from Hungateiclostridium thermocellum (HtXyl5A). Unlike HtXyl5A, PsXyn5A produced Araf-xylopyranose from RAX and did not hydrolyze 33-α-l-Araf-xylotetraose. Deletion of the CBM13 domain significantly decreased the activity toward insoluble corn xylan, indicating that CBM13 plays an essential role in hydrolyzing corn xylan.
The COVID-19 Pandemic in Hong Kong: Exploring the Gaps in COVID-19 Prevention Practices from a Social Justice Framework
Authors: Arat Gizem , Kerelian Narine N 
Published: November 2022

AbstractLike many settings worldwide, Hong Kong has recently been combatting the COVID-19 pandemic. Ethnic minorities have reported perceived discrimination via local media outlets. They have been stereotyped as virus spreaders due to the increasing number of confirmed cases and untraceable COVID-19 clusters in Hong Kong. Using a social justice framework, this qualitative study explores gaps in COVID-19 prevention practices to eliminate systemic barriers for ethnic minorities in Hong Kong. Fifteen interviews were conducted with social service providers who worked closely with ethnic minority groups (South and Southeast Asian groups from low-income households, foreign domestic workers and asylum seekers and refugees) during the fourth wave of the COVID-19 pandemic in Hong Kong. This study yielded six themes using thematic analysis as follows: (i) lacking mental health support for diverse ethnic minority groups; (ii) lacking efforts to eliminate perceived discrimination; (iii) existing language barriers across diverse services; (iv) lacking channels to disseminate accurate information; (v) a need for advanced technology and (vi) lacking appropriate surgical mask sizes for some ethnic minority individuals. This study recommends culturally responsive practices in Hong Kong.
Following the Indian Immigrant: adoption of westernization results in a western gut microbiome and an increased risk of inflammatory bowel diseases
Authors: D'Aloisio Leah D , Shetty Vignesh , Ballal Mamatha , Gibson Deanna L 
Published: November 2022

Abstract
Indians who migrate to westernized countries such as Canada, the USA, and the UK are at an increased risk of developing inflammatory bowel disease (IBD). While the underlying aetiology of IBD remains unclear, a gut microbiome, i.e. no longer symbiotic with its host, is a major player. Increasing IBD incidence in Indian immigrants may be due to the adoption of western practices that result in loss of tolerance of a symbiotic community in the gut and its underlying immune responses. However, little is known about the microbial changes in the Indian gut, including shifts in the microbiome when they migrate to westernized countries. In this Current Opinion, we discuss what is known about the Indian gut microbiome and how living in a westernized environment may be impeding what was once a symbiotic relationship with their gut microbiome and intestinal mucosae, which may be the driving factor in their increased risk of IBD.
An overview of erythritol production by yeast strains
Authors: Khatape Anil B , Dastager Syed G , Rangaswamy Vidhya 
Published: November 2022

AbstractErythritol is a 4-carbon polyol produced with the aid of microbes in presence of hyper-osmotic stress. It is the most effective sugar alcohol that is produced predominantly by fermentation. In comparison to various polyols, it has many precise functions and is used as a flavor enhancer, sequestrant, humectant, nutritive sweetener, stabilizer, formulation aid, thickener, and a texturizer. Erythritol production is a common trait in a number of the yeast genera viz., Trigonopsis, Candida, Pichia, Moniliella, Yarrowia, Pseudozyma, Trichosporonoides, Aureobasidium, and Trichoderma. Extensive work has been carried out on the biological production of erythritol through Yarrowia, Moniliella, Candida, and other yeast strains, and numerous strategies used to improve erythritol productivity through mutagenesis and genetic engineering are discussed in this review.
Development of sake yeast breeding and analysis of genes related to its various phenotypes
Authors: Negoro Hiroaki , Ishida Hiroki 
Published: November 2022

AbstractSake is a traditional Japanese alcoholic beverage made from rice and water, fermented by the filamentous fungi Aspergillus oryzae and the yeast Saccharomyces cerevisiae. Yeast strains, also called sake yeasts, with high alcohol yield and the ability to produce desired flavor compounds in the sake, have been isolated from the environment for more than a century. Furthermore, numerous methods to breed sake yeasts without genetic modification have been developed. The objectives of breeding include increasing the efficiency of production, improving the aroma and taste, enhancing safety, imparting functional properties, and altering the appearance of sake. With the recent development of molecular biology, the suitable sake brewing characteristics in sake yeasts, and the causes of acquisition of additional phenotypes in bred yeasts have been elucidated genetically. This mini-review summarizes the history and lineage of sake yeasts, their genetic characteristics, the major breeding methods used, and molecular biological analysis of the acquired strains. The data in this review on the metabolic mechanisms of sake yeasts and their genetic profiles will enable the development of future strains with superior phenotypes.
High-resolution surface mass loads in the Amazon Basin combining GRACE and river routing model
Authors: Youm Kookhyoun , Eom Jooyoung , Seo Ki-Weon , Chen Jianli , Wilson Clark R , Oh Seokhoon 
Published: November 2022

SUMMARYUnderstanding water redistribution on Earth's surface is essential to hydrological applications and water management. Variations in water mass loads have been observed by the Gravity Recovery and Climate Experiment (GRACE), but the low spatial resolution of GRACE limits determination of their distribution in detail. Hydrologic models provide higher spatial resolution water mass loads, but may include larger uncertainties. In this study, we develop high-resolution surface mass loads over the Amazon basin using forward modelling by combining GRACE data and a hydrologic model. River routing discharge is also included as a priori information because of the large water volume changes on relatively narrow channels in the Amazon basin. These high-resolution surface mass loads constrained by river routing agree with GRACE observations when spatially smoothed. Vertical deformation estimated from these high-resolution loads agree with Global Navigation Satellite System (GNSS) observations, at both seasonal and inter-annual timescales. In particular the most improved agreement is obtained at the NAUS GNSS station, close to the main channel of the Amazon, relative to predictions made using GRACE data. At two other stations (APSA and MAPA) near the main channel, the estimated vertical deformations apparently differ from observation, but much of the discrepancy is reduced when river path is corrected in river-routing model, indicating the importance of water loads on river channel to understand crustal displacement in the area.
Inversion of acoustic thunder source spectral model from thunder-induced seismic waves in megacity
Authors: Hong Tae-Kyung , Park Seongjun , Chung Dongchan , Kim Byeongwoo 
Published: November 2022

SUMMARYThunder-induced seismic waves recorded at dense seismic stations in Seoul, South Korea are analysed for inversion of thunder source spectra. Thunder-induced seismic waves from four local thunder events are analysed. A theory is introduced for the inversion of acoustic source spectra from thunder-induced seismic waves. In the course of source-spectral inversion, the propagation and acoustic-to-seismic coupling effects are counted. The thunder-induced seismic signals were well identified at distances of &lt;∼20 km. Direct acoustic-to-seismic coupled seismic waves present apparent phase velocities of sound speed in atmosphere (340 m s−1). Thunder-induced seismic waves are dominant at high frequencies (&gt;20 Hz). Vertical peak ground accelerations of thunder-induced seismic waves in local regions (0.024–0.110 m s−2 at distances of 2.4–3.7 km) are equivalent to the ground motion levels induced by a moderate-size (∼M5) earthquake at regional distances. The thunder-induced acoustic waves in the atmosphere are obtained by removing the acoustic-to-seismic coupling effect and site-response effect from the observed thunder-induced seismic waves. The quality factors for acoustic wave attenuation in the atmosphere are determined. Urban landscapes and atmospheric effects cause strong acoustic attenuation over atmospheric absorption. Acoustic thunder source spectra are determined by stacking the inverted acoustic spectra at all stations. The peak frequencies of acoustic thunder source spectra are around 34–36 Hz, suggesting the acoustic energy per unit length in lightning strikes to be ∼4 × 106 J m−1. Local seismic records are applicable for the investigation of thunder and lightning properties.
On various mechanisms of shear wave generation from underground chemical explosions in hard rocks
Authors: Vorobiev Oleg 
Published: November 2022

SUMMARY
Significant shear waves observed during underground explosions can make them look similar to natural earthquakes. In the near field, they can be caused by the source geometry and emplacement conditions, heterogeneous and anisotropic properties of the rock mass, relaxation of a non-uniform in situ stress around the source after the departure of the shock wave as well as by activation of nearby faults. The stress relaxation mechanism is important at depth when the difference in main principal stresses becomes significant. Another mechanism of shear motion generation is due to explosive gas flow from the source cavity into the cracks initiated by the shock wave and joints connected to the cavity. Also, the shock wave from the explosion can cause weakening of the rock either due to permanent damage or shock-induced liquefaction at saturated joints. Numerical modelling of underground chemical explosions in hard rock at various confinement stresses has been conducted to compare various mechanisms of shear wave generation and their seismic characteristics with that of a simple fault rupture process observed during an earthquake.
A cross-species co-functional gene network underlying leaf senescence
Authors: Liu Moyang , Guo Chaocheng , Xie Kexuan , Chen Kai , Chen Jiahao , Wang Yudong , Wang Xu 
Published: November 2022

AbstractThe complex leaf senescence process is governed by various levels of transcriptional and translational regulation. Several features of the leaf senescence process are similar across species, yet the extent to which the molecular mechanisms underlying the process of leaf senescence are conserved remains unclear. Currently used experimental approaches permit the identification of individual pathways that regulate various physiological and biochemical processes; however, the large-scale regulatory network underpinning intricate processes like leaf senescence cannot be built using these methods. Here, we discovered a series of conserved genes involved in leaf senescence in a common horticultural crop (Solanum lycopersicum), a monocot plant (Oryza sativa), and a eudicot plant (Arabidopsis thaliana) through analyses of the evolutionary relationships and expression patterns among genes. Our analyses revealed that the genetic basis of leaf senescence is largely conserved across species. We also created a multi-omics workflow using data from more than 10 000 samples from 85 projects and constructed a leaf senescence-associated co-functional gene network with 2769 conserved, high-confidence functions. Furthermore, we found that the mitochondrial unfolded protein response (UPRmt) is the central biological process underlying leaf senescence. Specifically, UPRmt responds to leaf senescence by maintaining mitostasis through a few cross-species conserved transcription factors (e.g. NAC13) and metabolites (e.g. ornithine). The co-functional network built in our study indicates that UPRmt figures prominently in cross-species conserved mechanisms. Generally, the results of our study provide new insights that will aid future studies of leaf senescence.
Exploring the prevalence and types of fall-risk-increasing drugs among older people with upper limb fractures
Authors: Cox Natalie , Ilyas Isra , Roberts Helen C , Ibrahim Kinda 
Published: November 2022

Abstract

Objectives
Medications and specifically fall-risk-increasing drugs (FRIDs) are associated with increased risk of falls: reducing their prescription may improve this risk. This study explored patient characteristics associated with FRID use, prevalence and type of FRIDs and changes in their prescriptions among older people with arm fractures over 6 months.

Methods
Observational prospective study in three fracture clinics in England. Patients aged ≥65 years with a single upper limb fragility fracture were recruited. The STOPPFall tool identified the number and type of FRIDs prescribed at baseline, 3- and 6-month follow-ups. Changes in FRID prescription were categorised as discontinued, new or exchanged.

Key findings
100 patients (median age 73 years; 80% female) were recruited. At baseline, 73% used ≥1 FRID daily (median = 2), reducing to 64% and 59% at 3 and 6 months, respectively. Those with &gt;1 FRID prescription had a significantly higher number of co-morbidities and medications and higher rates of male gender, polypharmacy, frailty and sarcopenia. The most frequently prescribed FRIDs were antihypertensives, opioids and antidepressants. Between 0 and 3 months, 44 (60%) participants had changes to FRID prescription: 20 discontinued (opioids and antihistamines), 13 started (antidepressants) and 11 exchanged for another. Similar trends were observed at 6 months.

Conclusion
Use of FRIDs among older people with upper limb fragility fractures was high. Although overall use decreased over time, 59% were still on ≥1 FRID at the 6-month follow-up, with trends to stop opioids and start antidepressants. Older people presenting with upper limb fractures should be offered a structured medication review to identify FRIDs for targeted deprescribing.
A randomized, placebo-controlled, blinded phase 1 study investigating a novel inactivated, Vero cell-culture derived Zika virus vaccine
Authors: Wressnigg Nina V , Hochreiter Romana , Schneider Martina , Obersriebnig Michaela J , Bézay Nicole I , Lingnau Karen , Ramljak Irena Čorbić , Dubischar Katrin L , Eder-Lingelbach Susanne 
Published: November 2022

Abstract

Background
Zika virus (ZIKV) is an emerging public health threat, rendering development of a safe and effective vaccine against the virus a high priority to face this unmet medical need. Our vaccine candidate has been developed on the same platform used for the licensed vaccine IXIARO®, a vaccine against Japanese Encephalitis virus, another closely related member of the Flaviviridae family.

Methods
Between 24 February 2018 and 16 November 2018, we conducted a randomized, observer-blinded, placebo controlled, single center phase 1 study to assess the safety and immunogenicity of an adjuvanted, inactivated, purified whole-virus Zika vaccine candidate in the USA. A total of 67 healthy flavivirus-naïve adults aged 18–49 years were randomly assigned to one of five study arms to receive two immunizations of either high dose or low dose (6 antigen units or 3 antigen units) with both dose levels applied in two different immunization regimens or placebo as control.

Results
Our vaccine candidate showed an excellent safety profile independent of dose and vaccination regimen with predominantly mild adverse events (AEs). No serious AE has been reported. The ZIKV vaccine induced neutralizing antibodies in all tested doses and regimens with seroconversion rates up to 85.7% (high dose), which remained up to 40% (high dose) at 6 months follow-up. Of note, the rapid regimen triggered a substantial immune response within days.

Conclusions
The rapid development and production of a ZIKV vaccine candidate building on a commercial Vero-cell manufacturing platform resulted in a safe and immunogenic vaccine suitable for further clinical development. To optimize antibody persistence, higher doses and a booster administration might be considered.
Using shell models to investigate clumping in the WN4 star HD 50896
Authors: Flores Brian L , Hillier D John , Dessart Luc 
Published: November 2022

ABSTRACT
The spectra of Wolf–Rayet (WR) stars exhibit strong, broad emission lines that originate in the wind. These winds are radiatively driven and are susceptible to hydrodynamic instabilities that result in the formation of clumps. When modelling spectra of WR stars the volume-filling factor (VFF) approach is usually employed to treat clumpy winds. However, it is based on the assumption that the entire wind mass resides in optically thin clumps, which is not necessarily justifiable in dense winds. To test the validity of the VFF approach, we use a previously described method of treating clumping, the ‘shell’ approach, to study line and continuum formation in the dense wind of the WN4 star, HD 50896. Our models indicate that fully intact spherical shells are in tension with observed spectra; a persistent ‘dip’ in emission lines occurs at line centre. Removing this dip requires our models to use ‘broken’ shells – shells that are highly decoherent laterally. This insinuates that the wind of HD 50896, and by extension the winds of other WR stars, are comprised of small laterally confined and radially compressed clumps – clumps smaller than the Sobolev length. We discuss some of the conditions necessary for the VFF approach to be valid.