bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultra‐Thin Asymmetric Composite Electrolyte Addresses the Out‐of‐Sync Requirements of Lithium Batteries Interfaces
Authors: Li Yang , Wang Guoxu , Fan Li‐Zhen 
Published: June 2022

AbstractAll‐solid‐state lithium batteries with solid‐state electrolytes (SSEs) have gained worldwide attention due to their intrinsic safety and high energy density. However, there is no single electrolyte that can satisfy the out‐of‐sync requirements of both the anode and cathode interface. Herein, an ultrathin asymmetric composite electrolyte (ACE) is prepared by a simple slurry‐casting method, in which a Li6.75La3Zr1.75Ta0.25O12 (LLZTO) enrichment layer with high modulus is used to match the lithium anode and a polymer layer with high electrochemical stability is formed at the cathode. Meanwhile, a polyimide (PI) film is used as a scaffold to improve the mechanical properties of the electrolyte. As a result, the ACE with a thickness of 35 μm exhibits an ionic conductivity of 1.34×10−4 S cm−1 at room temperature. Furthermore, both the LiNi0.5Co0.2Mn0.3O2/ACE/Li and LiFePO4/ACE/Li full cells exhibit excellent electrochemical performances.
Multivariate linear mixed models with censored and nonignorable missing outcomes, with application to AIDS studies
Authors: Lin Tsung‐I , Wang Wan‐Lun 
Published: June 2022

AbstractThe analysis of multivariate longitudinal data could encounter some complications due to censorship induced by detection limits of the assay and nonresponse occurring when participants missed scheduled visits intermittently or discontinued participation. This paper establishes a generalization of the multivariate linear mixed model that can accommodate censored responses and nonignorable missing outcomes simultaneously. To account for the nonignorable missingness, the selection approach which decomposes the joint distribution as a marginal distribution for the primary outcome variables and a model describing the missing process conditional on the hypothetical complete data is used. A computationally feasible Monte Carlo expectation conditional maximization algorithm is developed for parameter estimation with the maximum likelihood (ML) method. Furthermore, a general information‐based approach is presented to assess the variability of ML estimators. The techniques for the prediction of censored responses and imputation of missing outcomes are also discussed. The methodology is motivated and exemplified by a real dataset concerning HIV‐AIDS clinical trials. A simulation study is conducted to examine the performance of the proposed method compared with other traditional approaches.
Bioluminescence of the tropical Indian Ocean: a multiple‐scale variation
Authors: Piontkovski Sergey A. , Melnik Alexandr V. , Serikova Irina M. , Evstigneev Vladislav P. , Dobretsov Sergey 
Published: June 2022

AbstractLarge‐scale surveys represented by 5800 bathymetric casts in the western Indian Ocean (0–22oN, 54–58oE), elucidated the 10‐fold variation of the bioluminescent potential (BP) in the upper mixed layer, during the winter (north‐east) monsoon season. The mesoscale survey in February 2017 consisted of 26 drift stations (4oN–3oS, 65–68oE) on which 5–10 bathymetric casts were deployed down to 60 m. The maximal BP was associated with the periphery of a cyclonic eddy. The two‐fold to three‐fold variation of BP characterized the spatial heterogeneity modulated by a detected eddy. High‐frequency casts on drift stations resembled the fine‐scale heterogeneity in which the three‐fold variation was observed within the BP maximum at a 37 ± 13 m depth. The latter one was located above the deep chlorophyll maximum at a 80 m depth. A general decline of the BP variance from the large scale through mesoscale to fine scale, fits that of the zooplankton biomass.
Angiogenic and osteogenic effects of flavonoids in bone regeneration
Authors: Shanmugavadivu Abinaya , Balagangadharan Kalimuthu , Selvamurugan Nagarajan 
Published: June 2022

AbstractBone is a highly vascularized tissue that relies on a close spatial and temporal interaction between blood vessels and bone cells. As a result, angiogenesis is critical for bone formation and healing. The vascular system supports bone regeneration by delivering oxygen, nutrients, and growth factors, as well as facilitating efficient cell–cell contact. Most clinical applications of engineered bone grafts are hampered by insufficient vascularization after implantation. Over the last decade, a number of flavonoids have been reported to have osteogenic–angiogenic potential in bone regeneration because of their excellent bioactivity, low cost, availability, and minimal in vivo toxicity. During new bone formation, the osteoinductive nature of certain flavonoids is involved in regulating multiple signaling pathways contributing toward the osteogenic–angiogenic coupling. This review briefly outlines the osteogenic–angiogenic potential of those flavonoids and the mechanisms of their action in promoting bone regeneration. However, further studies are needed to investigate their delivery strategies and establish their clinical efficacy.
An updated review of SARS‐CoV‐2 detection methods in the context of a novel coronavirus pandemic
Authors: Zhang Yuxuan , Huang Zhiwei , Zhu Jiajie , Li Chaonan , Fang Zhongbiao , Chen Keda , Zhang Yanjun 
Published: June 2022

AbstractThe World Health Organization has reported approximately 430 million confirmed cases of coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), worldwide, including nearly 6 million deaths, since its initial appearance in China in 2019. While the number of diagnosed cases continues to increase, the need for technologies that can accurately and rapidly detect SARS‐CoV‐2 virus infection at early phases continues to grow, and the Federal Drug Administration (FDA) has licensed emergency use authorizations (EUAs) for virtually hundreds of diagnostic tests based on nucleic acid molecules and antigen–antibody serology assays. Among them, the quantitative real‐time reverse transcription PCR (qRT‐PCR) assay is considered the gold standard for early phase virus detection. Unfortunately, qRT‐PCR still suffers from disadvantages such as the complex test process and the occurrence of false negatives; therefore, new nucleic acid detection devices and serological testing technologies are being developed. However, because of the emergence of strongly infectious mutants of the new coronavirus, such as Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529), the need for the specific detection of mutant strains is also increasing. Therefore, this article reviews nucleic acid‐ and antigen–antibody‐based serological assays, and compares the performance of some of the most recent FDA‐approved and literature‐reported assays and associated kits for the specific testing of new coronavirus variants.
Pedagogy of transformation of a random variable, censoring, and truncation of data
Authors: Shankar P. Mohan 
Published: June 2022

AbstractThe author has been incorporating data analytics into the probability course for students pursuing baccalaureate programs in engineering through weekly assignments and end‐of‐the‐term projects. Data analytics makes the probability course much more relevant to the current trends in business, industry, and medicine that rely on data. The discussion related to the coronavirus pandemic about missing and incomplete data, the inability to pinpoint the exact start of the disease, and so forth offered an opportunity to expand activities in data analytics by examining “truncation” and “censoring” of data. In simple terms, truncation implies the exclusion of data (either not collected or ignored) in a certain range. Censoring implies redefining the data in a certain range while keeping the rest of the original data. A demo was created to explore the association of the transformation of random variables (mixed and conditional) to censoring and truncation. The demo utilized the theory of random variables, simulation, and computational techniques to examine and establish the link between the mixed transformation of variables and censoring. A similar link of conditional transformation of variables to truncation was also seen. The demo was used as the basis for a weekly assignment to the students. The analysis and results suggest that it is possible to expand the scope of the course in engineering probability to provide training in contemporary topics in data analytics.
Bacterial Peroxidase on Electrochemically Reduced Graphene Oxide for Highly Sensitive H2O2 Detection
Authors: Bhardwaj Sheetal K. , Knaus Tanja , Garcia Amanda , Yan Ning , Mutti Francesco G. 
Published: June 2022

AbstractPeroxidase enzymes enable the construction of electrochemical sensors for highly sensitive and selective quantitative detection of various molecules, pathogens and diseases. Herein, we describe the immobilization of a peroxidase from Bacillus s. (BsDyP) on electrochemically reduced graphene oxide (ERGO) deposited on indium tin oxide (ITO) and polyethylene terephthalate (PET) layers. XRD, SEM, AFM, FT‐IR and Raman characterization of the sensor confirmed its structural integrity and a higher enzyme surface occupancy. The BsDyP‐ERGO/ITO/PET electrode performed better than other horseradish peroxidase‐based electrodes, as evinced by an improved electrochemical response in the nanomolar range (linearity 0.05–280 μM of H2O2, LOD 32 nM). The bioelectrode was mechanically robust, active in the 3.5–6 pH range and exhibited no loss of activity upon storage for 8 weeks at 4 °C.
Impact of left ventricular outflow tract calcium on valve geometry in self‐expanding transcatheter aortic‐valve replacement
Authors: Medranda Giorgio A. , Rogers Toby , Fuery Michael , Case Brian C. , Collins Erin C. , Ali Syed W. , Zhang Cheng , Wang John C. , Weissman Gaby , Cohen Jeffrey E. , Shults Christian C. , Satler Lowell F. , Ben‐Dor Itsik , Waksman Ron 
Published: June 2022

AbstractObjectivesEvaluate transcatheter heart valve (THV) geometry according to left ventricular outflow tract (LVOT) calcium degree and its impact on hemodynamics and outcomes in patients undergoing transcatheter aortic valve replacement (TAVR) with a contemporary self‐expanding THV.BackgroundLVOT calcium remains challenging for contemporary THVs. LVOT calcium location and degree may affect THV deployment and impact flow patterns and shear stress, accelerating THV degeneration.MethodsEPROMPT (CoreValve Evolut Pro Prospective Registry; NCT03423459) is a prospective, investigator‐initiated, multicenter registry of patients undergoing TAVR using CoreValve Evolut PRO/PRO + THVs. A total of 107 patients were enrolled in EPROMPT's computed tomography (CT) cohort between January 2018 and October 2021. These patients underwent follow‐up CT scan 30 days post‐TAVR. We analyzed THV geometry and its interaction with the aortic root following deployment using 30‐day post‐TAVR CT in patients with none/mild versus moderate/severe LVOT calcium.ResultsThirty‐day THV inflows were less eccentric in the short axis in patients with none/mild versus moderate/severe LVOT calcium (1.16 ± 0.09 vs. 1.21 ± 0.12; p = 0.007). THV became more circular and was similar between both cohorts at the THV waist (1.08 ± 0.06 vs. 1.09 ± 0.11; p = 0.551), leaflet tips (1.03 ± 0.04 vs. 1.05 ± 0.09; p = 0.299), and THV outflow (1.04 ± 2.2 vs. 1.03 ± 2.7; p = 0.143). Thirty‐day > mild paravalvular leak was low in both cohorts (1.5% vs. 2.4%; p = 0.724); mean gradients were similar (7.7 ± 3.6 vs. 7.7 ± 3.4 mmHg; p = 0.955).ConclusionsDespite inflow deformities observed in patients with moderate/severe LVOT calcium, Evolut PRO/PRO + conforms to elliptical aortic annuli, maintaining circularity and proper function at the leaflets and outflow, even in patients with moderate/severe LVOT calcium.
Anticoagulation for left ventricular thrombi secondary to COVID—Is 3 months too long?
Authors: Garg Rimmy , Sachdeva Amitoj , Del Cid Fratti Juan , Mortoti Samuel 
Published: June 2022

AbstractThe length of anticoagulation for thrombotic events related to COVID‐19 is unknown. We present a patient with COVID‐19 complicated by a thrombotic anterior STEMI and multiple left ventricular (LV) thrombi that resolved after 8 weeks of anticoagulation. We suggest a shorter length of anticoagulation with COVID‐19‐related LV thrombus.
A case of prenatal diagnosis of 16q24.3 microdeletion KBG syndrome and review of the literature
Authors: Deng Tianqin , Liu Qingzhi , Xie Jiansheng , Li Xuemei , Yao Bing 
Published: June 2022

AbstractHere we report a case of a 16q24.3 microdeletion KBG syndrome (KBGS) in a fetus. The absence of a well‐defined phenotype poses a challenge for genetic diagnosis. This report demonstrated that the high‐risk chromosome 21 trisomy could be the first manifestation of KBGS, as observed in this case.
Fat necrosis: A neglected side effect of intramuscular injections
Authors: Chaima Kouki , Mariem Amouri , Emna Bahloul , Slim Charfi , Fatma Hammemi , Tahya Boudawara , Hamida Turki 
Published: June 2022

AbstractPanniculitis has various etiologies. One of the less common causes is trauma and hence traumatic fat necrosis (FN). These soft tissue injuries usually appear on the shins, thighs, breasts, arms, and buttocks. FN is mainly caused by trauma and may be associated with other conditions such as pancreatic disease. FN arising after intramuscular injections is uncommon and usually appears as firm, encapsulated, mobile, nontender, and solitary or multiple subcutaneous nodules. We report an interesting case of FN caused by intramuscular injections of cefazolin and meglumine antimoniate (MA) in a 38‐year‐old female patient. MA is regarded as the first‐line systemic treatment for cutaneous leishmaniasis (CL). However, these drugs are not devoid of various potentially adverse reactions.
Vascular injury due to a peripherally inserted central catheter in a neonate born during the 24th week of gestation
Authors: Kurimoto Tomonori , Yonishi Ryo , Uehara Hirotaka , Fukuzato Hayato , Seki Satoko , Shimoji Yoshikazu , Nakayama Okitaka , Ohba Chiaki , Nakazato Iwao , Ohshiro Tatsuo 
Published: June 2022

AbstractWe investigated a case of a peripherally inserted central venous catheter associated with iliolumbar venous extravasation in an infant. Hyperosmolar infusion and calcium gluconate caused phlebitis and vascular perforation. Daily monitoring of the catheter length at the insertion site and serial radiography may aid in detecting catheter movement.
Towards Full‐spectrum Photocatalysis: Extending to the Near‐infrared Region
Authors: Li Jiaxuan , Arif Nayab , Lv Tao , Fang Hui , Hu Xuejuan , Zeng Yu‐Jia 
Published: June 2022

AbstractThe ability to use the full solar spectrum energy in photocatalytic processes for environmental remediation and energy production has attracted worldwide attention. Efficient harvesting of near‐infrared (NIR) photons, especially in the wavelength range beyond 800 nm, is one of the main driving forces in photocatalytic research. The design of appropriate photocatalytic systems for wide‐range light‐harvesting from the UV to NIR regions is a promising method of maximizing the efficiency of solar energy utilization. This review comprehensively summarizes the recent progress in full‐solar‐light‐driven photocatalytic systems, including several strategies to harness NIR light and thermal energy. The corresponding photocatalytic mechanisms and design of binary or ternary heterogeneous systems are discussed in detail. Moreover, future perspectives and challenges are presented to inspire the development of further innovations in full‐solar‐light‐driven photocatalysis.
N/O‐co‐doped Carbon Shell Structures Loaded with Iron Phthalocyanine for Oxygen Reduction Catalysis
Authors: Li Xuhui , Zhao Ruixue , Fu Yuanyuan , Xu Dawei , Kang Yunpeng , Li Kai , Li Zhongfeng , Zheng Lirong , Zuo Xia 
Published: June 2022

AbstractMetal phthalocyanines (MPcs) have highly conjugated π electron systems and metal atoms acting as active centers, and so exhibit excellent electrocatalytic performance during the oxygen reduction reaction (ORR). However, these complexes also tend to undergo aggregation and exhibit poor electrical conductivity and minimal durability, all of which hinder their large‐scale industrial applications. In the present study, iron phthalocyanine (FePc) is applied to hollow carbon shells (HCSs) to generate an ORR catalyst containing single Fe atoms(HCS‐O‐FePc). The HCSs have numerous N/O‐based surface functional groups that promote the formation of Fe−O bonds with the FePc held in an axial coordination position. These axial Fe−O bonds disrupt the electron symmetry in the plane of the FePc molecules, which facilitate electron transfer. 1100HCS‐O‐FePc exhibits an onset potential of 0.98 V (vs RHE), a half‐wave potential of 0.91 V (vs RHE), an electron transfer number of 3.90, and durability better than that of a 20 % commercial Pt/C catalyst. Electrochemical impedance spectroscopy demonstrates that the ORR process over this material likely proceeds via a rapid 2+2 electron mechanism. This composite displays excellent oxygen reduction properties and is a promising alternative to Pt‐based ORR catalysts.
Interlayer Engineering of KxMnO2 Enables Superior Alkali Metal Ion Storage for Advanced Hybrid Capacitors
Authors: Chen Lina , Zhang Yamin , Hao Chongyang , Zheng Xiaowen , Sun Qidi , Wei Youri , Li Bohao , Ci Lijie , Wei Jun 
Published: June 2022

AbstractThe lack of ideal cathode materials is a great challenge in the development of hybrid capacitors based on various alkali metal ions. In this work, potassium‐ion pre‐intercalated KxMnO2 nanowires with enlarged interplanar spacing and optimized ion diffusion channels are successfully obtained through a hydrothermal process, and exhibit superior electrochemical property in lithium‐, sodium‐, and potassium‐ion‐based hybrid supercapacitors (HSCs). The potassium‐ion hybrid supercapacitor (KIC) assembled with a KxMnO2 cathode and activated carbon anode delivers a high energy density of 49.2 Wh kg−1, a high power density of 4.7 kW kg−1, and outstanding cycling performance up to 7000 cycles with almost no capacitance decay, which outperforms most of the KICs reported previously. This ion intercalation engineering provides a strategy to design high‐performance cathodes for hybrid capacitors and other battery systems.
Pyrimidoquinazolinophenanthroline Opens Next Chapter in Design of Bridging Ligands for Artificial Photosynthesis**
Authors: Brückmann Jannik , Müller Carolin , Maisuradze Tamar , Mengele Alexander K. , Nauroozi Djawed , Fauth Sven , Gruber Andreas , Gräfe Stefanie , Leopold Kerstin , Kupfer Stephan , Dietzek‐Ivanšić Benjamin , Rau Sven 
Published: June 2022

AbstractThe synthesis and detailed characterization of a new Ru polypyridine complex containing a heteroditopic bridging ligand with previously unexplored metal‐metal distances is presented. Due to the twisted geometry of the novel ligand, the resultant division of the ligand in two distinct subunits leads to steady state as well as excited state properties of the corresponding mononuclear Ru(II) polypyridine complex resembling those of prototype [Ru(bpy)3]2+ (bpy=2,2'‐bipyridine). The localization of the initially optically excited and the nature of the long‐lived excited states on the Ru‐facing ligand spheres is evaluated by resonance Raman and fs‐TA spectroscopy, respectively, and supported by DFT and TDDFT calculations. Coordination of a second metal (Zn or Rh) to the available bis‐pyrimidyl‐like coordination sphere strongly influences the frontier orbitals, apparent by, for example, luminescence quenching. Thus, the new bridging ligand motif offers electronic properties, which can be adjusted by the nature of the second metal center. Using the heterodinuclear Ru−Rh complex, visible light‐driven reduction of NAD+ to NADH was achieved, highlighting the potential of this system for photocatalytic applications.
How Ionization Catalyzes Diels–Alder Reactions
Authors: Vermeeren Pascal , Hamlin Trevor A. , Bickelhaupt F. Matthias 
Published: June 2022

AbstractInvited for the cover of this issue are Pascal Vermeeren, Trevor A. Hamlin, and F. Matthias Bickelhaupt of the TheoCheM group at the Vrije Universiteit Amsterdam. The cover art depicts how ionizing the dienophile lowers the Diels–Alder reaction barrier between 1,3‐butadiene and acrylaldehyde by reducing the destabilizing steric Pauli repulsion and enhancing the stabilizing orbital interactions. Read the full text of the article at 10.1002/chem.202200987.
Association of area‐level socioeconomic status and non–small cell lung cancer stage by race/ethnicity and health care–level factors: Analysis of the National Cancer Database
Authors: Gupta Anjali , Omeogu Chioma H. , Islam Jessica Y. , Joshi Ashwini R. , Akinyemiju Tomi F. 
Published: June 2022

BackgroundThis study examined whether the association of socioeconomic status (SES) and non–small cell lung cancer (NSCLC) stage varied by race/ethnicity and health care access measures.MethodsThis study used data from the 2004–2016 National Cancer Database for patients aged 18–89 years who had been diagnosed with Stage 0–IV NSCLC. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were calculated for the associations of area‐level SES with an advanced stage at diagnosis via multilevel, multivariable logistic regression. The stage at diagnosis was dichotomized into early (0–II) and advanced (III–IV) stages, and area‐level SES was categorized on the basis of the patient's zip code level: (1) the proportion of adults aged ≥25 years without a high school degree and (2) the median household income. The models were stratified by race/ethnicity (non‐Hispanic [NH] White, NH Black, Hispanic, Asian, American Indian/Alaskan Native, and Native Hawaiian/Pacific Islander), insurance status (none, government, and private), and health care facility type (community, comprehensive community, academic/research, and integrated network).ResultsThe study population included 1,329,972 patients. Although only 17% of the NH White patients were in the lowest income quartile, 50% of the NH Black patients were in this group. Lower area‐level education and income were associated with higher odds of an advanced‐stage diagnosis (aOR for education, 1.12; 95% CI, 1.10–1.13; aOR for income, 1.13; 95% CI, 1.11–1.14). These associations persisted among NH White, NH Black, Hispanic, and Asian patients; among those with government and private insurance (but not the uninsured); and among those treated at each facility type.ConclusionsArea‐level income and education are strongly associated with an advanced NSCLC diagnosis regardless of the facility type and among those with government and private insurance.
Triflic‐Acid‐Catalyzed Friedel‐Crafts Reaction for the Synthesis of Diaryl Sulfones
Authors: Falconnet Alban , Arndt Jan‐Dirk , Hashmi A. Stephen K. , Schaub Thomas 
Published: June 2022

AbstractThe Friedel‐Crafts sulfonylation for the synthesis of diaryl sulfones derivatives was achieved by using triflic acid (TfOH) as the acidic catalyst with aryl sulfonyl chlorides and arenes at elevated temperatures. Different sulfones could be synthesized with this method in good to excellent yield and with high selectivity. In contrast to the previous methodology reported for this sulfonylation, the catalyst and the excess of arene could be easily recovered and re‐used in further batches.