bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced glycation end products induce senescence of atrial myocytes and increase susceptibility of atrial fibrillation in diabetic mice
Authors: Zheng Dan‐Lin , Wu Qing‐Rui , Zeng Peng , Li Sui‐Min , Cai Yong‐Jiang , Chen Shu‐Zhen , Luo Xue‐Shan , Kuang Su‐Juan , Rao Fang , Lai Ying‐Yu , Zhou Meng‐Yuan , Wu Fei‐Long , Yang Hui , Deng Chun‐Yu 
Published: October 2022

AbstractDiabetes mellitus (DM) is a common chronic metabolic disease caused by significant accumulation of advanced glycation end products (AGEs). Atrial fibrillation (AF) is a common cardiovascular complication of DM. Here, we aim to clarify the role and mechanism of atrial myocyte senescence in the susceptibility of AF in diabetes. Rapid transesophageal atrial pacing was used to monitor the susceptibility of mice to AF. Whole‐cell patch‐clamp was employed to record the action potential (AP) and ion channels in single HL‐1 cell and mouse atrial myocytes. More importantly, anti‐RAGE antibody and RAGE‐siRNA AAV9 were used to investigate the relationship among diabetes, aging, and AF. The results showed that elevated levels of p16 and retinoblastoma (Rb) protein in the atrium were associated with increased susceptibility to AF in diabetic mice. Mechanistically, AGEs increased p16/Rb protein expression and the number of SA‐β‐gal‐positive cells, prolonged the action potential duration (APD), reduced protein levels of Cav1.2, Kv1.5, and current density of ICa,L, IKur in HL‐1 cells. Anti‐RAGE antibody or RAGE‐siRNA AAV9 reversed these effects in vitro and in vivo, respectively. Furthermore, downregulating p16 or Rb by siRNA prevented AGEs‐mediated reduction of Cav1.2 and Kv1.5 proteins expression. In conclusion, AGEs accelerated atrial electrical remodeling and cellular senescence, contributing to increased AF susceptibility by activating the p16/Rb pathway. Inhibition of RAGE or the p16/Rb pathway may be a potential therapeutic target for AF in diabetes.
External Validity and Meta‐Analysis
Authors: Slough Tara , Tyson Scott A. 
Published: October 2022

AbstractMeta‐analysis is a method that combines estimates from studies conducted on different samples, in different contexts, or at different times. Social scientists increasingly use meta‐analyses to aggregate evidence and learn about general substantive phenomena. We develop a framework to examine the theoretical foundations of meta‐analysis, with emphasis on clarifying the role of external validity. We identify the conditions under which multiple studies are target‐equivalent, meaning they identify the same empirical target. Our main result shows that external validity and harmonization, in comparisons made and how outcomes are measured, are necessary and sufficient for target‐equivalence. We examine common formulations of meta‐analysis—fixed‐ and random‐effects models—developing the theoretical assumptions that underpin them and providing design‐based identification results for these models. We then provide practical guidance based on our framework and results. Our results reveal limits to agnostic approaches to the combination of causal evidence from multiple studies.
Effect of news and noise shocks of US monetary policy on economic fluctuations in emerging market economies
Authors: Kim Wongi , Kim Kyunghun 
Published: October 2022

AbstractThis study investigates the effect of news and noise shocks of US monetary policy on economic fluctuations in emerging market economies. In the first part of our two‐step estimation method, the news and noise shocks of US monetary policy are estimated using dynamic structural vector autoregression identification. In the second step, the impact of the news and noise shocks on macro variables reflecting the business cycle (e.g., production, consumption, investment and trade balance) is examined using local projection. Our empirical results show no significant differences in the responses to both shocks at the early stage, when news and noise are not separable. However, when the monetary policy becomes known, emerging market economies enter a full‐scale recession with respect to a news shock of raised US interest rates. Meanwhile, emerging market economies enter an economic boom phase of the business cycle when the shock turns out to be noise. Fluctuations driven by noise are likely to incur greater costs than normal economic fluctuations because the former are out of sync with the fundamentals.
The psychometric properties of Turkish version of the Modified Paediatric Mini Mental Scale
Authors: Kurt Merve , Savaş Dilan , Tarsuslu Şimşek Tülay , YİŞ Uluç 
Published: October 2022

AbstractBackgroundChildren with neurological diseases suffer from neurocognitive problems due to both the disease and the treatment processes. Therefore, it is necessary that a battery can be used to determine and track the cognitive function of these children. The aim of this study is to establish the Turkish version of the Modified Paediatric Mini Mental Scale (MPMMS), ensure its cultural adaptation, and test the validity and reliability of the Turkish version of the MPMMS.MethodsSixty‐five children with the neurological condition were enrolled in this methodological study. The subjects' age, height, weight, and body mass index were recorded. The MPMMS and the social function subscale of the Paediatric Evaluation of Disability Inventory (PEDI) were used to assess the participants' cognitive function. The construct validity of the questionnaire was determined by the correlation between the MPMMS and the social function subscale of the PEDI. Cronbach's alpha was calculated to determine internal consistency. To determine test–retest reliability, 32 children were assessed 7–14 days after the initial assessment, and the intraclass correlation coefficient (ICC) was calculated.ResultsThe mean age of the participants was 9.26 ± 3.87 years. A very strong significant correlation was found between the MPMMS and social function subscale of the PEDI (r = 0.935, p = 0.000). The internal consistency of the MPMMS was excellent (Cronbach's alpha = 0.932).ConclusionsThe Turkish version of the MPMMS has excellent validity and reliability and can be used by professionals in various health care settings to determine children's cognitive abilities.
Gender quotas in the Arab world ‐ 20 years on
Authors: Welborne Bozena C. , Buttorff Gail J. 
Published: October 2022

AbstractThis article aims to survey the state of the literature on gender quotas in the Middle East and North Africa (MENA), explicitly focusing on where it stands in terms of their institutional, political, and societal impact after two decades of implementation. In addition, it considers how MENA scholarship on the topic compares with the global literature and includes insights into how region‐specific work contributes to our understanding of gender quotas as an electoral and legislative institution overall.
Moral friends? The idea of the moral relationship
Authors: Vandieken Jonas 
Published: October 2022

AbstractWhat role do human relationships play within the moral domain? There appears to be a lot of agreement that relationships play an important role in and for morality, but certainly not any foundational one. Yet, there has been a recent interest in seeking to explain the foundation of morality in relational terms. According to these relational proposals, the very foundation of impartial morality, and in particular the domain of “what we owe to each other” can be found in the same normative structures that are characteristic of interpersonal relationships and the partial reasons they give rise to. This suggestion has been met with serious criticism, according to which any seeming appeal to a so‐called moral relationship does no work in grounding morality and the obligations that we owe to each other. The present paper intends to challenge this conclusion by arguing that the objections rendered are not decisive, as a result of which we can begin to make sense of the idea that we do share a reason‐giving relationship with each other in the moral sphere. The moral relationship, the paper argues, is one we simply share with each other in virtue of our shared vulnerability to attitudinal injury as rational agents.
Compressive creep buckling of single cell metamaterial at elevated temperatures
Authors: Fitzgerald Kaitlynn M. , Berfield Thomas A. , Torbati‐Sarraf Hamid , Pataky Garrett J. 
Published: October 2022

AbstractThe benefits of tailored lattice topologies are limited in elevated temperature conditions without a clear understanding about the interplay between the metamaterial structure and the creep response of the base material. This study showed that the metamaterial structure causes the lattice compressive creep behavior to differ largely from that of bulk structures of the same base material. Inconel 625 FCCZ lattices and solid round bar specimens were crept in compression at two elevated temperatures and at three stress levels. The solid round bar specimens experienced only small increases in the steady state creep rate with a steady state exponent of 0.35 and 0.63 at 550°C and 650°C. The solid round bar specimens did not exhibit a deformation mechanism change over the temperatures and stress levels tested. The FCCZ lattices exhibited much larger changes in creep rates with changing stress and temperature with a steady state exponent of 18.3 and 20.2 at 550°C and 650°C, respectively. Additionally, the lattice specimens experienced three different failure behaviors with increasing temperature and stress from stable creep, to progressive buckling, and finally rapid collapse.
Moving through liquid territories: A cartographic history of roads in the Danube Delta
Authors: Constantinescu Ștefan , Tănăsescu Mihnea 
Published: October 2022

AbstractWe present an analysis of the Danube Delta (Romania) that is focused on the evolution and use of roads, so as to highlight the primacy of movement in spatialisation and the fluidity of roads themselves. We demonstrate that local inhabitants of the Danube Delta have relied on a network of roads for survival and have in the process fitted themselves to a deltaic space full of affordances that foreign observers have missed. Our objectives are achieved by juxtaposing a cartographic archive spanning from the 19th century up to 2019 with the lived experience of the deltaic space. The maps we uncover and redraw show how the road infrastructure in the Danube Delta has evolved. We explain what has driven this evolution by interpreting the archive in light of long‐term field work (2015–2019). This allows us to re‐characterise the deltaic space as a hybrid of solidity and liquidity, and to show the evolution of the local perspective in relation to traversing this complicated land. This is a completely new historical and cartographic contribution to a severely understudied area, the Danube Delta.
Global seasonal and pandemic patterns in influenza: An application of longitudinal study designs
Authors: Naumova Elena N. , Simpson Ryan B. , Zhou Bingjie , Hartwick Meghan A. 
Published: October 2022

SummaryThe confluence of growing analytic capacities and global surveillance systems for seasonal infections has created new opportunities to further develop statistical methodology and advance the understanding of the global disease dynamics. We developed a framework to characterise the seasonality of infectious diseases for publicly available global health surveillance data. Specifically, we aimed to estimate the seasonal characteristics and their uncertainty using mixed effects models with harmonic components and the δ‐method and develop multi‐panel visualisations to present complex interplay of seasonal peaks across geographic locations. We compiled a set of 2 422 weekly time series of 14 reported outcomes for 173 Member States from the World Health Organization's (WHO) international influenza virological surveillance system, FluNet, from 02 January 1995 through 20 June 2021. We produced an analecta of data visualisations to describe global travelling waves of influenza while addressing issues of data completeness and credibility. Our results offer directions for further improvements in data collection, reporting, analysis and development of statistical methodology and predictive approaches.
Can support by digital technologies stimulate intrapreneurial behaviour? The moderating role of management support for innovation and intrapreneurial self‐efficacy
Authors: Rabl Tanja , Petzsche Valentin , Baum Matthias , Franzke Sonja 
Published: October 2022

AbstractDrawing on theorising on digital technologies as external enablers of entrepreneurial activities and an interactionist perspective on corporate entrepreneurship, this article examines the relationship between digital technology support and employee intrapreneurial behaviour. We propose that management support for innovation as an organisational characteristic and intrapreneurial self‐efficacy as an individual characteristic moderate this relationship. Findings from a metric conjoint experiment with 1360 decisions nested within 85 employees showed that support by social media, support by collaborative technologies, and support by intelligent decision support systems were significant predictors of employee intrapreneurial behaviour. However, the relative impact of support by these digital technologies varied with different levels of management support for innovation and intrapreneurial self‐efficacy.
Global research status of pathological scar reported over the period 2001–2021: A 20‐year bibliometric analysis
Authors: Li Shiyi , Ding Hongfan , Yang Yi , Yu Boya , Chen Minliang 
Published: October 2022

AbstractPathological scar is a classic problem in plastic and reconstructive surgery. Although the researches on pathological scar have been conducted for decades, the way to go to address this thorny problem still remains challenging. To the best of our knowledge, few bibliometric analysis concerning pathological scar have been reported. In this study, we set out to employ bibliometric and visual analysis to offer research status and trends of pathological scar over the period 2001–2021. All publications covering pathological scar during 2001–2021 were retrieved and extracted from the Web of Science database. We applied VOSviewer software to evaluate the keywords and research hotpots, and the online tool (http://bibliometric.com/) was used to carried out the publication trends analysis. A total of 2221 pathological scar‐related articles were identified over the period 2001–2021. China is the country which had the largest volume of publications (819, 36.87%), followed by the United States (416, 18.73%), Japan (144, 6.48%), Korea (142, 6.39%), and England (118, 5.31%). Among the institutions and journals, Shanghai Jiao Tong University (167) and Wound Repair and Regeneration (85) accounted for the most papers related to pathological scar, respectively. Professor Bayat A, who had the most citation frequency (2303), made great contribution in pathological scar field. “Fibroblast”, “expression”, and “proliferation” were identified as the pathological scar research hotspot through analysis of the keywords. In terms of publication, China ranked first all over the world, but the numbers of publication are inconsistent with the citation frequency, ranking first and second, respectively. Shanghai Jiao Tong University and journal Wound Repair and Regeneration stand for the highest level of research in this field to a certain extent. In the early stage, the research focus was mainly on the prevention, treatment, and risk factors for recurrence of pathological scar from cases. In the later stage, the research focus was on the comprehensive management, in which the mechanism research was in‐depth to the molecular and gene level.
Generation rent on the housing treadmill: A study on South Korea's housing allowance programmes and recurring precarity
Authors: Han Seon Hoe , Kim Jisun , Park Nara 
Published: October 2022

AbstractGiven the ongoing economic crisis and the increase in housing prices, many young adults —known as “generation rent”—use a large portion of their wages for rent and cannot buy a house. In South Korea, generation rent in lower income brackets are particularly vulnerable to overlapping precarities as housing inequality worsens. In response, South Korean local governments have offered housing allowance programmes since 2019, but studies on the impact of housing allowance on young adults are scant. This article examines how and to what extent housing allowance for young adults relieves precarity through a grounded theory approach. Eighteen young adults who benefit from the programme participated in in‐depth interviews. Results show that after living independently, participants experienced multidimensional precarity: housing, financial, professional and social support exclusion. To alleviate their precarity, they applied for a housing allowance programme, thereby experiencing changes. Although their precarity was reduced, it was not entirely allayed because of the programme's short duration, which kept them stuck on the “housing treadmill.”
Logical anti‐exceptionalism meets the “logic‐as‐models” approach
Authors: Becker Arenhart Jonas R. 
Published: October 2022

AbstractLogical anti‐exceptionalism is the view that logic is not special, it is continuous with science. This continuity is typically understood in terms of the use of the abductive method in logical theory choice, with logical knowledge resulting from our choice of the theory best accounting for the data. In this paper, we argue for two related claims: (i) that this understanding of the continuity between logic and science faces considerable challenges; and (ii) that such challenges may be avoided by elaborating the continuity of logic with science in terms of the “logic‐as‐models” approach. More specifically, we defend that logical theories should be seen in the lights of the “models‐as‐epistemic‐tools” approach, an approach to the nature of models in empirical science more closely connected with current scientific practice. The result is a version of logical anti‐exceptionalism opening new perspectives for the philosophical understanding of logic.
Predictors of long-term intraocular pressure control after lens extraction in primary angle closure glaucoma: results from the EAGLE trial
Authors: Mitchell William G , Azuara-Blanco Augusto , Foster Paul J , Halawa Omar , Burr Jennifer , Ramsay Craig R , Cooper David , Cochran Claire , Norrie John , Friedman David , Chang Dolly 
Published: October 2022

Background/aimsTo assess baseline ocular parameters in the prediction of long-term intraocular pressure (IOP) control after clear lens extraction (CLE) or laser peripheral iridotomy (LPI) in patients with primary angle closure (PAC) disease using data from the Effectiveness of Early Lens Extraction for the treatment of primary angle-closure glaucoma (EAGLE) tria.MethodsThis study is a secondary analysis of EAGLE data where we define the primary outcome of ‘good responders’ as those with IOP<21 mm Hg without requiring additional surgery and ‘optimal responders’ as those who in addition were medication free, at 36-month follow-up. Primary analysis was conducted using a multivariate logistic regression model to assess how randomised interventions and ocular parameters predict treatment response.ResultsA total of 369 patients (182 in CLE arm and 187 in LPI arm) completed the 36-month follow-up examination. After CLE, 90% met our predefined ‘good response’ criterion compared with 67% in the LPI arm, and 66% met ‘optimal response’ criterion compared with 18% in the LPI arm, with significantly longer drops/surgery-free survival time (p<0.05 for all). Patients randomised to CLE (OR=10.1 (6.1 to 16.8)), Chinese (OR=2.3 (1.3 to 3.9)), and those who had not previously used glaucoma drops (OR=2.8 (1.6 to 4.8)) were more likely to maintain long-term optimal IOP response over 36 months.ConclusionPatients with primary angle closure glaucoma/PAC are 10 times more likely to maintain drop-free good IOP control with initial CLE surgery than LPI. Non-Chinese ethnicity, higher baseline IOP and using glaucoma drops prior to randomisation are predictors of worse long-term IOP response.
Management of psychiatric and cognitive complications in Parkinson’s disease
Authors: Weintraub Daniel , Aarsland Dag , Biundo Roberta , Dobkin Roseanne , Goldman Jennifer , Lewis, Simon 
Published: October 2022

Abstract
Neuropsychiatric symptoms (NPSs) such as affective disorders, psychosis, behavioral changes, and cognitive impairment are common in Parkinson’s disease (PD). However, NPSs remain under-recognized and under-treated, often leading to adverse outcomes. Their epidemiology, presentation, risk factors, neural substrate, and management strategies are incompletely understood. While psychological and psychosocial factors may contribute, hallmark PD neuropathophysiological changes, plus the associations between exposure to dopaminergic medications and occurrence of some symptoms, suggest a neurobiological basis for many NPSs. A range of psychotropic medications, psychotherapeutic techniques, stimulation therapies, and other non-pharmacological treatments have been studied, are used clinically, and are beneficial for managing NPSs in PD. Appropriate management of NPSs is critical for comprehensive PD care, from recognizing their presentations and timing throughout the disease course, to the incorporation of different therapeutic strategies (ie, pharmacological and non-pharmacological) that utilize a multidisciplinary approach.
Country-specific estimates of unintended pregnancy and abortion incidence: a global comparative analysis of levels in 2015–2019
Authors: Bearak Jonathan Marc , Popinchalk Anna , Beavin Cynthia , Ganatra Bela , Moller Ann-Beth , Tunçalp Özge , Alkema Leontine 
Published: October 2022

IntroductionInternationally comparable estimates of unintended pregnancy and abortion incidence can illuminate disparities in sexual and reproductive health and autonomy. Country-specific estimates are essential to enable international comparison, and to inform country-level policy and programming.MethodsWe developed a Bayesian model which jointly estimated unintended pregnancy and abortion rates using information on contraceptive needs and use, contraceptive method mix, birth rates, the proportions of births from unintended pregnancies and abortion incidence data. Main outcomes were the estimated rates of unintended pregnancy and abortion for 150 countries and territories, reported for the 5-year period 2015–2019, as annual averages per 1000 women aged 15–49 years.ResultsEstimated unintended pregnancy rates ranged from 11 (80% uncertainty interval: 9 to 13) in Montenegro to 145 (131 to 159) in Uganda per 1000 women aged 15–49 years. Between-country heterogeneity was substantial in all Sustainable Development Goal (SDG) regions, but was greatest in sub-Saharan Africa. Estimated abortion rates ranged from 5 (5 to 6) in Singapore to 80 (55 to 113) in Georgia. Variation between country estimates was similar in all SDG regions except for Europe and Northern America, where estimated abortion rates were generally lower.ConclusionThe estimates reflect variation in the degree to unintended pregnancy and abortion that are experienced in countries throughout the world. This evidence highlights the importance of investing in access to contraception and comprehensive abortion care, including in regions which may have lower rates of unintended pregnancy or abortion, respectively, as countries may differ substantially from regional averages.