bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paediatric subarachnoid haemorrhage and severe vasospasm secondary to traumatic pseudoaneurysm of a fenestrated vertebral artery: A case report and review of the literature
Authors: Kameda-Smith Michelle Masayo , James Gregory , Rennie Adam , Robertson Fergus , Silva Dulanka 
Published: November 2022

Abstract
Paediatric intracranial aneurysms are rare entities accounting for less than 5% of all age intracranial aneurysms. Traumatic aneurysms are more common in children and have an association with anatomical variations such as arterial fenestrations. Here we present a case of a child initially presenting with traumatic subarachnoid haemorrhage who returned to baseline and was discharged home only to return within 2 weeks with diffuse subarachnoid and intraventricular re-haemorrhage. A dissecting aneurysm of a duplicated (fenestrated) V4 vertebral artery segment was identified as a rare cause of rebleeding. We describe a course complicated by severe vasospasm delaying aneurysm detection and treatment. Dissecting aneurysms in children should be considered in all cases of delayed post-traumatic cranial rebleeding, particularly where there is anomalous arterial anatomy.
Resonant Laser Ionization and Mass Separation of 225Ac
Authors: Johnson Jake David , Heines Michael , Bruchertseifer Frank , Chevallay Eric , Cocolios Thomas Elias , Dockx Kristof , Duchemin Charlotte , Heinitz Stephan , Heinke Reinhard , Hurier Sophie , Lambert Laura , Leenders Benji , Skliarova Hanna , Stora Thierry , Wojtaczka Wiktoria 
Published: November 2022

Abstract
225Ac is a radio-isotope that can be linked to biological vector molecules to treat certain distributed cancers using targeted alpha therapy. However, developing 225Ac-labelled radiopharmaceuticals remains a challenge due to the supply shortage of pure 225Ac itself. Several techniques to obtain pure 225Ac are being investigated, amongst which is the high-energy proton spallation of thorium or uranium combined with resonant laser ionization and mass separation. As a proof-of-principle, we perform laser ionization and mass separation on two samples of 225Ac, each with a known activity, in different chemical environments. We report overall operational collection efficiencies of 10.1(2)% and 9.9(8)% for the cases in which the 225Ac was deposited on a rhenium surface and a ThO2 mimic target matrix respectively. The bottleneck of the technique was the laser ionization efficiency, which was deduced to be 15.1(6)%.
Specific thresholds for emerging cardiometabolic risk markers of elevated carotid intima – media thickness (CIMT) in uncontrolled hypertensive patients in a hospital setting in Kinshasa, DR Congo
Authors: TONGO Stéphane YANDA , LONGO-MBENZA Benjamin , Michel LELO TSHIKWELA , MALENGELE Héritier MAWALALA , WOLA Antoine TSHIMPI , RISASI Jean Robert MAKULO , LUSUNSI Christian KISOKA , MONKONDJIMOBE Etienne 
Published: November 2022

Abstract
Objective:
To identify independent determinants of selected emerging cardiometabolic risk factors of increased carotid intima – media thickness (CIMT) in uncontrolled hypertensive patients in a hospital setting in Kinshasa.
Material and method:
A cross-sectional study was performed between September 2018 and January 2021 in hypertensive patients admitted to Cliniques Universitaires de Kinshasa (CUK), Centre Hospitalier Mère et Enfant Monkole (CHME) and Hôpital Biamba Marie Mutombo (HBMM) to measure CIMT on ultra sonography.
Some cardiometabolic and atherogenic markers were evaluated by Receiver Operating Characteristic (ROC) and logistical regression.
Results:
280 hypertensive patients were examined with 72.9% uncontrolled hypertension.
The CMIT threshold >0.8 mm associated with uncontrolled hypertension was significantly and independently predictive of subclinical atherosclerosis.
Conclusion:
The present study identified independent determinants of increased CIMT in globally uncontrolled hypertensive patients in a hospital setting in Kinshasa, DR Congo.
Thus, the optimal and specific thresholds for subclinical atherosclerosis were: urinary albumin/creatinine ratio, TyG Index, BMI and LVMI in the direction of health promotion and atherosclerosis prevalence in the management of hypertensive patients in the hospital setting of Kinshasa, DR Congo.
Effects of fertilization and understory removal on aboveground and belowground carbon stocks in wet and dry moorlands in southwestern France
Authors: Bon Lucie , Augusto Laurent , Gaudry Jonathan , Bakker Mark R. , Lambrot Catherine , Milin Sylvie , Trichet Pierre , Fanin Nicolas 
Published: November 2022

Abstract
Forests provide essential ecosystem services such as wood production and soil carbon storage, which can be influenced by forest management. Fertilization and understory removal (UR) are common practices set up in managed forests to reduce tree mortality and relieve trees from their main limitations, but their effects on belowground functioning and soil carbon storage are still unclear. In this study, we investigated the effects of fertilization, UR and their interaction on the carbon stored in the ecosystem and soil enzyme activities in two different moorlands in southwestern France (dry and wet moorlands) planted with maritime pines (Pinus pinaster Ait.). Our results showed that fertilization had a positive effect on tree biomass in the wet moorland, but did not affect soil organic carbon stocks. In contrast, UR had a positive influence on tree biomass in both sites, whereas it had a strong negative effect on soil organic carbon stocks in the dry moorland only. Furthermore, we found that carbon-related enzyme activities were not affected by fertilization, but decreased with UR in the dry moorland. When looking at the carbon pools, we found that fertilization increased total carbon stocks in the wet moorland due to an increase in aboveground biomass. In contrast, UR did not affect total carbon stocks in the dry moorland due to compensatory effects with an increase of carbon stored in the aboveground biomass coupled to a decrease of carbon stored in the soil. These results highlight the importance of adapting forest practices depending on the environmental context.
Oridonin attenuates the progression of atherosclerosis by inhibiting NLRP3 and activating Nrf2 in apolipoprotein E-deficient mice
Authors: Wang Lei , Zhao Xiaoqi , Ding Jiawen , Liu Yutong , Liu Han , Zheng Lei , Zhao Hongting , Sun Zichen , Li Kuanyu , Cai Jing , Qiao Tong 
Published: November 2022

Abstract
Oridonin, a well-known traditional Chinese herbal medicinal product isolated from Isodon rubescens (Hemsl.) H.Hara, has many potential properties, including anti-inflammatory and antioxidant activities. However, there is no evidence whether oridonin have a protective effect on atherosclerosis. This study focused on the effects of oridonin on oxidative stress and inflammation generated from atherosclerosis. The therapeutic effect on atherosclerosis was evaluated by intraperitoneal injection of oridonin in a high-fat fed ApoE−/− mouse model. We isolated mouse peritoneal macrophages and detected the effect of oridonin on oxidized low-density lipoprotein-induced lipid deposition. Oil red O staining, Masson's staining, Dihydroethidium (DHE) fluorescence staining, Immunohistochemical staining, western blotting analysis, immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and quantitative real-time PCR were used to evaluate the effect on atherosclerosis and explore the mechanisms. Oridonin treatment significantly alleviated the progression of atherosclerosis, reduced macrophage infiltration and stabilized plaques. Oridonin could significantly inhibit inflammation associated with NLRP3 activation. Oridonin significantly reduced oxidative stress by blocking Nrf2 ubiquitination and degradation. We also found that oridonin could prevent the formation of foam cells by increasing lipid efflux protein and reducing lipid uptake protein in macrophages. Oridonin has a protective effect on atherosclerosis in ApoE−/− mice, which may be related to the inhibition of NLRP3 and the stabilization of Nrf2. Therefore, oridonin may be a potential therapeutic agent for atherosclerosis.
Down regulation of Cathepsin W is associated with poor prognosis in Pancreatic cancer
Authors: Khojasteh-Leylakoohi Fatemeh , Mohit Reza , Khalili-Tanha Nima , Asadnia Alireza , Khazaei Majid , Pourali Ghazaleh , Yousefli Zahra , Khalili-Tanha Ghazaleh , Maftooh Mina , Nassiri Mohammadreza , Hassanian Seyed Mahdi , Ghayour-Mobarhan Majid , Ferns Gordon A , Shahidsales Soodabeh , Giovannetti Elisa , Nazari Elham , Avan Amir 
Published: November 2022

Abstract

Background:Pancreatic ductal adenocarcinoma (PDAC) is associated with a very poor prognosis. Therefore, there has been a focus on the identification of new biomarkers for the early diagnosis of PDAC and prediction of patient survival. Genome-wide RNA and microRNA sequencing were used using bioinformatics and Machine Learning approaches to identify differentially expressed genes (DEGs) followed by validation in additional cohort of PDAC patients.Methods:genome RNA sequencing and clinical data from pancreatic cancer patients were extracted from The Cancer Genome Atlas Database (TCGA) to identify DEGs. We used Kaplan-Meier analysis of survival curves was used to assess prognostic biomarkers. Ensemble learning, Random Forest, (RF), Max Voting, Adaboost, Gradient boosting machines (GBM) and Extreme Gradient Boosting (XGB) techniques were used and Gradient boosting machines (GBM) were selected with 100 % accuracy for analysis. Moreover, protein-protein interaction (PPI), molecular pathways, concomitant expression of DEGs, and correlations between DEGs and clinical data were analyzed. We have evaluated candidate genes, miRNAs and a combination of these obtained from machine learning algorithms and survival analysis.Results:Machine learning results showed 23 genes with negative regulation, 5 genes with positive regulation, 7 microRNAs with negative regulation and 20 microRNAs with positive regulation in PDAC. Key genesBMF,FRMD4A,ADAP2,PPP1R17, andCACNG3had the highest coefficient in the advanced stages of disease. In addition, the survival analysis results showed decreased expression ofhsa.miR.642a,hsa.mir.363,CD22,BTNL9andCTSWand overexpression ofhsa.miR.153.1,hsa.miR.539,hsa.miR.412reduced survival rate.CTSWwas identified as a novel genetic marker and this was validated using RT-PCR.Conclusion:Machine learning algorithms may be used to Identify key dysregulated genes/miRNAs involved in pathogenesis of the diseases can be used for detection of patients in earlier stages. Our data also demonstrated the prognostic and diagnostic value ofCTSWin PDAC.
Preparation of solid acid of sulfated binary metal oxides via solid-liquid interface reaction
Authors: Matsuhashi Hiromi , Onoki Reiko , Yoshida Kana , Nishiyama Yuuki 
Published: November 2022

Abstract
Solid acid catalysts composed of sulfated binary metal oxides, SO42–/TiO2–ZrO2, SO42–/Fe2O3–Al2O3, SO42–/ZrO2–Al2O3, and SO42–/Al2O3–ZrO2 were prepared via a solid-liquid interface reaction of the corresponding hydrated metal sulfates with a metal alkoxide. Sulfated SnO2–TiO2 was prepared via the interface reaction of tin(IV) oxyhydroxide containing nonstoichiometric water molecules with titanium alkoxide. The sulfated binary oxides exhibited greater activity than proton-type zeolites and sulfated zirconia for acid-catalyzed ethanol dehydration. The activation temperatures that provided the highest activity were the same or higher than those for sulfated simple metal oxides. The Al2O3 included in the prepared binary oxides was amorphous even when the heat treatment was conducted at higher temperatures. An increase in thermal stability was observed for anatase–phase TiO2 and tetragonal-phase ZrO2. A well-mixed solid solution was formed by the reaction of Ti(OCH(CH3)2)4 with SnO(OH)2 containing nonstoichiometric water molecules. The SO42–/SnO2–TiO2 showed extremely higher activity in the tested catalysts.
Source Investigations, Quality Indexing of Vegetable Farmland and Human Health Risk Implications
Authors: Alam M. Nur E , Hosen M. Mozammal , Ullah A. K. M. Atique , Maksud M. A. , Khan S. R. , Lutfa L. N. , Choudhury T. R. , Quraishi Shamshad B. 
Published: November 2022

Abstract
Climate changes effects, food security and self-sufficiency targets in densely populated countries like Bangladesh forced excessive human activities on vegetable farmland, and heavy metal contamination may result. An analysis of three toxic heavy metals, such as lead (Pb), cadmium (Cd), and chromium (Cr), was conducted to determine their source and associated health risks in vegetables, taking into account source pathways, fertilizers/pesticides and soil, using 12 sampling points at two different locations in two different Flam-Atomic Absorption Spectrometry (F-AAS) and Graphite Furnace-AAS (GF-AAS) modes. In soil and fertilizers/pesticides, the mean concentration of heavy metals declined in the same order of Cr > Pb > Cd. For vegetables, the mean concentration decreased in the order of Pb > Cr > Cd with some extra quantity of Pb compared with an allowable limit of World Health Organization (WHO) predicting industrial and fertilizer usage impact on location B. For both locations, the quality indexing of soil projected low levels of contamination with insignificant ecological risks. The toxic metal transfer to vegetables followed the order Cd > Pb > Cr, the same for both locations but higher at location B. However, the toxic metals uptake through vegetables was much less than maximum tolerable daily intake. The human health risks arising from harmful metals exposure at both locations were ineffective (< 1) in evaluating non-carcinogenic risk patterns through target hazard quotient (THQ), total THQ and hazard index (HI). Again considering probable carcinogenic risk patterns, vegetable consumption with studied exposure levels of toxic metals will be significant (between 1.0E-04 to 1.0E-04). Overall, location B is a little bit more vulnerable than A by considering the non-carcinogenic and carcinogenic model and related intervention and protective measures are needed to be taken.
Non-binary gender statistic of employees in Australian universities
Authors: boretti alberto 
Published: November 2022

Abstract
Here we analyze the data of reference Australian higher education institutions in the state of Victoria to understand the differences between genders in their workforce and the society. It is found that the previous unbalance in favor of assigned males at birth persisting in their original definition, classified as males, has been turned into an unbalance in favor of assigned females at birth persisting in their original definition, classified as females. The 2SLGBTQIA + community, summarily classified as Self-described, is still largely underrepresented. The number of Self-described Executives is not even reported by two of the four universities, and it is reported as zero by the other two. One university has an empty field for the number of Self-Described total staff same as the year before. The average of the total number of Self-Described staff to the total number of staff of the three universities with an entry is only 0.31%.
Third-order Optical Nonlinearity Investigations of axially linked hyperbranched lanthanum phthalocyanine-boron nitride nanosheets
Authors: Li Wei , Yang Jiansong , Zhang Xiaofang , Xu Rui 
Published: November 2022

Abstract
Developing nonlinear optical materials with wide wavelength range for optical confinement is of wide application prospects and immense scientific interest. In the present work, a novel nanohybrid materials (HLaPc-BNNSs) was designed through axially covalent connected boron nitride (BN) to phthalocyanine. The third-order nonlinear optical properties of HLaPc-BNNSs in organic solvents and polymer matrix were investigated separately. The HLaPc-BNNSs nanohybrid exhibits a wide limiting range and its nonlinear optical properties show a significant improvement in the near-infrared region. In addition, the solid film samples exhibit better uniformity and excellent nonlinear optical response compared to the solution samples. The nonlinear absorption coefficient (β) of the HLaPc-BNNSs/PPSU films is as high as 1800 (cm/GW), which is almost 200 times higher than that of the 532 nm solution absorption coefficient. Possible mechanisms of optical confinement were explored by various methods, including UV-vis absorption, fluorescence, and Z-scan. It is demonstrated that the synergistic effect of two-photon absorption with reverse saturable absorption and charge transfer between BNNSs and HLaPc are important factors in determining its nonlinear optical response and optical limiting performances. Therefore, the preparation of axially connected hyperbranched phthalocyanines and two-dimensional nanomaterials is a new strategy for the design and development of high-efficiency optical limiting functional nano-hybrid materials.
Sophomoric sex ed: Sexism through definition in collegiate sexuality education textbooks
Authors: Willeford Chloe Kearin , Etgen Caroline J. , Jordan Carly N. 
Published: November 2022

Abstract
The majority of adolescents in the United States receive formal sexuality and sexual health education, making it important that information presented therein is accurate and unbiased. Sexual education presents a pattern of describing men as active and sexually driven and women as passive victims of men’s sexual urges. Our research found that this pattern manifests in sexual health textbooks, when female anatomy is described only in terms of male anatomy. We read and analyzed anatomy chapters in ten of the most common sexual education textbooks used in American high schools and colleges to determine how bodies of each sex were defined and found a statistically significant correlation with a large effect size between the sex of anatomy and the incidence of description of that anatomy from the perspective of another sex. This analysis shows that sexual health textbooks continue to depict women as sexual tools for men, contributing to the sexism in American society. Sexism has negative psychological effects on women from an early age. Our research highlights the frequency with which women receive sexist messages in education, compounding these negative psychological effects.
Endometriosis and Adverse Pregnancy Outcomes, controversies debates
Authors: Shahmoradi Fatemeh , Haghighi Ladan , Noori Marziyeh , Derakhshan Roya , Hashemi Neda , rokhgireh samaneh 
Published: November 2022

Abstract
The association between endometriosis and outcome of pregnancy is one of the interesting topics. Patients' pain is alleviated with pregnancy, but it seems that endometriosis causes adverse outcomes in pregnancy. The main accused is systemic chronic inflammation caused by higher level of cytokines, growth factors and angiogenic factors. In this retrospective cohort study, the case group included 125 women with endometriosis who referred to Hazrat-e- Rasool hospital in 2015–2019, and the control group included 125 women without endometriosis who went to the hospital for delivery in 2015–2019. Data on pregnancy, delivery and newborns of the endometriosis and control group was extracted from the hospital information system and the questionnaires were completed. The average age of patients was 32.74 ± 4.10 and 31.7 ± 5.53 years in endometriosis and control group respectively. In terms of pregnancy complications, placenta previa, placenta accreta, placenta abruption pre-eclampsia, GDM and postpartum hemorrhage remarkably increase in the endometriosis group compared to the control group (P < 0.05). In bowel endometriosis SGA was significantly higher than patients without bowel endometriosi. (P < 0.05). Conservative or surgical treatment of rectal endometriosis had no significant effect on pregnancy outcome (P > 0.05). As well as the presence of adenomyosis made pregnancy outcomes significantly unfavorable compared to people without adenomyosis. (P < 0.05). NICU admission rate was notably higher in infants of endometriosis group compared to controls (40.7% vs. 24.8%, P-value 0.009). Infant mortality rate had no significant difference in both groups (P = 0.12). Our findings showed that endometriosis and adenomyosis are related to bad obstetric consequences.
A mixed Harris hawks optimization algorithm based on the pinhole imaging strategy for solving numerical optimization problems
Authors: Zeng Liang , Li Yanyan , Zhang Hao , Li Ming , Wang Shanshan 
Published: November 2022

Abstract
To address the shortcomings of the Harris Hawks Optimization (HHO) algorithm in solving complex high-dimensional optimization problems with a slow convergence speed, low accuracy, and the high likelihood to fall into local optimum, a Mixed Harris Hawks Optimization (MHHO) algorithm based on the pinhole imaging strategy is proposed. Firstly, the pinhole imaging strategy is used to enable the Harris' hawks to approach the optimal solution faster and accelerate convergence. Secondly, the spiral parameter is introduced into the exploration phase to help the searching paths of the Harris' hawks more diverse, and improve the global search ability of the algorithm. Finally, the greedy strategy of the aquila optimization algorithm and the position update strategy of the ower pollination optimization algorithm are embedded in the exploitation stage to make the algorithm jump out of local optimum effectively. To verify the effectiveness of the proposed MHHO algorithm,it is compared with the classical HHO algorithm and 16 other state-of-the-art algorithms, and extensively tested on 23 well-known benchmark functions, the IEEE CEC2017 test set, and three complex constrained engineering optimization problems. The test results show that MHHO outperforms the classical HHO algorithm and other 16 algorithms,and has a faster convergence speed and higher convergence accuracy.