bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria
Authors: Musa Jonah , Kim Kyeezu , Zheng Yinan , Qu Yishu , Joyce Brian T. , Wang Jun , Nannini Drew R. , Gursel Demirkan B. , Silas Olugbenga , Abdulkareem Fatimah B. , Imade Godwin , Akanmu Alani S. , Wei Jian-Jun , Kocherginsky Masha , Kim Kwang-Youn A. , Wehbe Firas , Achenbach Chad J. , Anorlu Rose , Simon Melissa A. , Sagay Atiene , Ogunsola Folasade T. , Murphy Robert L. , Hou Lifang 
Published: April 2022

BackgroundInvasive cervical cancer (ICC) is a serious public health burden in Nigeria, where human immunodeficiency virus (HIV) remains highly prevalent. Previous research suggested that epigenetic age acceleration (EAA) could play a role in detection of HIV-associated ICC. However, little research has been conducted on this topic in Africa where the population is most severely affected by HIV-associated ICC. Here, we investigated the association between ICC and EAA using cervical tissues of ICC-diagnosed Nigerian women living with HIV.MethodsWe included 116 cervical tissue samples from three groups of Nigerian women in this study: (1) HIV+/ICC+ (n = 39); (2) HIV+/ICC- (n = 53); and (3) HIV-/ICC + (n = 24). We utilized four DNA methylation-based EAA estimators; IEAA, EEAA, GrimAA, and PhenoAA. We compared EAA measurements across the 3 HIV/ICC groups using multiple linear regression models. We also compared EAA between 26 tumor tissues and their surrounding normal tissues using paired t-tests. We additionally performed a receiver operating characteristics (ROC) curve analysis to illustrate the area under the curve (AUC) of EAA in ICC.ResultsWe found the most striking associations between HIV/ICC status and PhenoAge acceleration (PhenoAA). Among HIV-positive women, PhenoAA was on average 13.4 years higher in women with ICC compared to cancer-free women (P = 0.005). PhenoAA was 20.7 and 7.1 years higher in tumor tissues compared to surrounding normal tissues among HIV-positive women (P = 0.009) and HIV-negative women (P = 0.284), respectively. We did not find substantial differences in PhenoAA between HIV-positive and HIV-negative women with ICC.ConclusionPhenoAA is associated with ICC in HIV-infected women in our study. Our findings suggest that PhenoAA may serve as a potential biomarker for further risk stratification of HIV-associated ICC in Nigeria and similar resource-constrained settings.
Metformin Attenuates Inflammatory Responses and Enhances Antibody Production in an Acute Pneumonia Model of Streptococcus pneumoniae
Authors: Lee Grace C. , Moreira Alvaro G. , Hinojosa Cecilia , Benavides Raymond , Winter Caitlyn , Anderson Audrey C. , Chen Chang-Jui , Borsa Noemi , Hastings Gabrielyd , Black Cody A. , Bandy Sarah M. , Shaffer Alexander , Restrepo Marcos I. , Ahuja Sunil K. 
Published: April 2022

Metformin may potentially reverse various age-related conditions; however, it is unclear whether metformin can also mitigate or delay the deterioration of immunological resilience that occurs in the context of infections that are commonly observed in older persons. We examined whether metformin promotes the preservation of immunological resilience in an acute S. pneumoniae (SPN) infection challenge in young adult mice. Mice were fed metformin (MET-alone) or standard chow (controls-alone) for 10 weeks prior to receiving intratracheal inoculation of SPN. A subset of each diet group received pneumococcal conjugate vaccine at week 6 (MET + PCV and control + PCV). Compared to controls-alone, MET-alone had significantly less infection-associated morbidity and attenuated inflammatory responses during acute SPN infection. Metformin lowered the expression of genes in the lungs related to inflammation as well as shorter lifespan in humans. This was accompanied by significantly lower levels of pro-inflammatory cytokines (e.g., IL6). MET + PCV vs. control + PCV manifested enhanced SPN anticapsular IgM and IgG levels. The levels of SPN IgM production negatively correlated with expression levels of genes linked to intestinal epithelial structure among MET + PCV vs. control + PCV groups. Correspondingly, the gut microbial composition of metformin-fed mice had a significantly higher abundance in the Verrucomicrobia, Akkermansia muciniphila, a species previously associated with beneficial effects on intestinal integrity and longevity. Together, these findings indicate metformin’s immunoprotective potential to protect against infection-associated declines in immunologic resilience.
Estimating the Coronal Supra-Arcade Downflow Radio Emission: From Centimeter Through Submillimeter Wavelengths
Authors: Zurbriggen Ernesto , Giménez De Castro C. Guillermo , Costa Andrea , Cécere Mariana , Selhorst Caius L. 
Published: April 2022

Supra-arcade downflows (SADs) are infrequent, wiggly, and low-emission structures observed to descend through the solar corona, mostly in EUV and soft X-ray frequencies. Based on their physical characteristics, SADs have been interpreted as low-density bubbles and are related to magnetic reconnection processes during long-term erupting flares. In this work, we use numerical MHD simulations to compute flux density maps, which are convolved with telescope beams to synthesize images with the aim to assess the expected SAD emission in radio wavelengths. We assume that the emission is thermal bremsstrahlung from a fully ionized plasma and without any appreciable gyroresonance contribution since magnetic fields are of the order of 10 G. We find that SAD emission should be optically thin in the frequency range of [10–1,000] GHz, and the spatially integrated flux should be larger than 1 Jy. We conclude, therefore, that SADs consistently are less bright than the surrounding fan and that observing SADs in radio frequencies between [0.5–1,000] GHz is feasible with present instrumentation. The observing strategies are proposed, including the instruments that can be used. Moreover, since the emission is, for the most part, optically thin, the flux density is proportional to temperature, density, and line-of-sight depth and when combined with EUV and soft X-ray images may allow a better density and temperature determination of SADs.
The Learning Curve of Unilateral Biportal Endoscopic (UBE) Spinal Surgery by CUSUM Analysis
Authors: Chen Lei , Zhu Bin , Zhong Hua-zhang , Wang Yi-guo , Sun Yi-song , Wang Qi-fei , Liu Jian-jun , Tian Da-sheng , Jing Jue-hua 
Published: April 2022

ObjectiveTo assess the learning curve of the unilateral biportal endoscopic (UBE) technique for the treatment of single-level lumbar disc herniation by cumulative summation (CUSUM) method analysis.MethodsA retrospective analysis was conducted to assess 97 patients' general condition, operation time, complications, and curative effect of single segmental UBE surgery performed by a spinal surgeon in his early stage of this technique. The learning curve of operation time was studied using a CUSUM method, and the cut-off point of the learning curve was obtained.ResultsThe operation time was 30 – 241(97.9 ± 34.7) min. The visual analog scale score of lower limb pain decreased from 5.75 ± 0.81 before the operation to 0.39 ± 0.28 at the last follow-up (P &lt; 0.05). The Oswestry disability index score decreased from 66.48 ± 4.43 before the operation to 14.57 ± 3.99 at the last follow-up (P &lt; 0.05). The CUSUM assessment of operation time revealed the learning curve was the highest in 24 cases. In the learning stage (1–24 cases), the operation time was 120.3 ± 43.8 min. In the skilled stage (25–97 cases), the operation time was 90.5 ± 27.8 min.ConclusionsAbout 24 cases of single segmental UBE operation are needed to master the UBE technique.
Clinical Study on Treatment of Acute Lower Extremity Arterial Embolism With Straub Thrombus Removal System
Authors: Zhao Liang , Cai Hui , Song Qiang 
Published: April 2022

BackgroundAcute lower extremity arterial embolism (ALEAE) is a common and frequently occurring disease in clinics. Although thrombectomy with arteriotomy has been widely used and developed in clinics, there is a high probability of embolic recurrence after operation. The present study investigated the clinical efficacy of the Straub Rotarex system in the treatment of ALEAE, as it could remove exfoliative substances in acute and chronic cavities and expose diseased vessels.Materials and MethodsWe accessed our institutional database and retrospectively screened all patients with ALEAEs who received surgical treatment between April 2018 and April 2021. To observe the clinical efficacy, surgical indicators, incidence of postoperative complications, and recurrence rate of treatment with Straub Rotarex system and arteriotomy thrombectomy and analyze the risk factors for recurrence of embolism after treatment with Straub Rotarex system by multivariate Logistic regression model.ResultsFinally, 64 patients were included as the research object. The total effective rates of the observation group and the control group after operation were 100 and 93.75% respectively, and there was no significant difference between the two groups (P &gt; 0.05). The intraoperative blood loss, postoperative off-bed time and hospital stay time in the observation group were significantly lower than those in the control group, and the operation time and hospitalization expenses were significantly higher than those in the control group (P &lt; 0.05). The incidence of postoperative complications in the observation group was 3.13%, which was significantly lower than 18.76% of that in the control group (P &lt; 0.05). The recurrence rates of the observation group and the control group were 15.63 and 18.76%, respectively. There was no significant difference in the recurrence rate between the two groups (P &gt; 0.05). Atrial fibrillation was an independent risk factor for recurrence after the Straub thrombus removal system (P &lt; 0.05).ConclusionStraub thrombus removal system is an effective method for the treatment of ALEAE. Although it prolongs the operation time and increases the operation cost as compared with thrombectomy, it effectively improves the operation safety, postoperative life quality, and postoperative recovery, thus, worthy of clinical promotion. Atrial fibrillation is an independent risk factor for recurrent embolism after the Straub thrombus removal system. Paying attention to the clinical diagnosis and treatment of patients with atrial fibrillation is of great significance for patients to choose a reasonable treatment, prevent a recurrence, and improve the prognosis.
Emergency Department Management of COVID-19 Suspected Patients. An International Perspective
Authors: El Tawil Chady , El Hussein Mahmoud , Souaiby Nagi , Helou Mariana 
Published: April 2022

Objectives: In December 2019, an invasive viral outbreak, the Corona Virus Disease 19 spread to the whole world. An international cross-sectional study was conducted to evaluate how healthcare workers in Emergency departments dealt with this pandemic.Methods: A questionnaire was sent to 180 healthcare workers around the world during May and June of the year 2020.Results: A total of 134 HCW from 23 countries responded with a majority of Emergency physicians (36.8%). The PCR testing is available in 72.9% of the hospitals. Different architectural strategies were used to isolate suspected cases in the Emergency department (ED). Half of the institutions would not allow visitors, while the other half, restricted visiting hours and the number of visitors. Triage for suspected patients relied in 82.8% on symptoms. Almost 98% of HCW used a combination of mask, gloves, gown and face shield. Around 65% of the HCW have a tendency to discharge more patients from the ED than what they were used to.Conclusion: The COVID-19 pandemic made a major change within the emergency departments worldwide.
Social Media Analysis and Strategic Recommendations for a Non-Profit Organization in Germany
Authors: Giersemehl Franziska , Michelis Daniel , Stumpp Stefan 
Published: April 2022

Nowadays it is impossible to imagine life without social media - Facebook, Instagram and Co. have become important platforms for public discourse, political communication and opinion-forming.
Not only for companies, but also for nonprofit organizations (NPO), networking via social media creates potential. On the one hand, they offer a cost-effective dialog opportunity to address many interested parties and new target groups. On the other hand, the interaction of high-quality content and strategically planned social media posts not only gains reach, but also members and donations for the organization. At the same time, social media opens up space for hate speech, discrimination and racism, which is why a strategy to steadfastly counter negative reactions online is becoming increasingly important for nonprofit organizations as well.
The purpose of this paper is to examine how the regional nonprofit organization in the welfare sector – German Red Cross district association in Leipzig and the surrounding region – is targeting social media communications to achieve its established goals of recruitment and fundraising.
Unlike previous studies that focus on single social media platforms, this study examines the use of multiple social media platforms. This study included a qualitative analysis. We used qualitative content analysis (Mayring, 2015) to gain in-depth findings into the social media work of the NPO and its competitors.
In the first step, competitors of the NPO were selected for the analysis based on their activities on the social media profiles on Facebook, Instagram, Twitter and YouTube. For the selection of the competitors, own selection measures were chosen in order to make a suitable sample selection. Content categorization was used to interpret information within the social media profiles. The focus was on the textual and visual design of the social media accounts and individual posts of the competitors. For this purpose, the period of data collection included the months of June and September 2020. In summary, posts from 17 social media profiles were considered in the analysis, and we analyzed 21 Facebook posts, 12 Instagram posts, 15 tweets, and 20 YouTube videos.
Based on the results, a strategic approach for the social media work of the non-profit organization could be developed in the form of recommendations for action. In addition, more donation campaigns are to be included in social media. Emotional storytelling leads to more interactions, which can generate a higher willingness to donate.
Perancangan Sistem Informasi Geografis Pariwisata Pasaman Barat Berbasis Android Menggunakan Metode Haversine
Authors: Edy Suranta G.S Sugeng Purwantoro 
Published: April 2022

Wisata merupakan kegiatan yang banyak dilakukan oleh masyarakat saat ini yang bertujuan untuk mencari suasana baru diluar aktifitas rutin harian. Daerah tujuan wisata di sumatera cukup banyak dan beragam sekali salah satunya lokasi wisata yang berada di kabupaten Pasaman Barat. Namun banyak objek wisata yang tidak diketahui oleh para wisatawan yang berkunjung, disebabkan karena kurangnya informasi objek wisata yang tersedia. Sistem Informasi Geografis (SIG) dapat menyediakan informasi lokasi suatu tempat, yang dapat digunakan untuk menampilkan lokasi objek wisata yang dibutuhkan oleh para wisatawan. Perancangan sistem ini memberikan perhitungan estimasi jarak dan rekomendasi lokasi jarak terdekat menggunakan metode Haversine yang berfungsi untuk menghitung jarak antara dua titik. Sistem dirancang pada platform android, database MySQL dan bahasa pemograman PHP. Pengujian menggunakan pengujian White Box, Black Box, dan pengujian perbandingan dengan Google Maps Distance. Pada pengujian White Box pada kode program Haversine Formula dan kode program tampilan wisata didapatkan hasil nilai Cyclomatic Complexity 1 dan 2, disimpulkan kode program memliki level resiko yang sederhana dan tanpa banyak resiko sehingga mudah dilakukan maintenance dan diuji alur programnya. Pengujian Black Box disimpulkan bahwa fungsionalitas sistem berjalan dengan baik, pada analisa pengujian perbandingan didapatkan nilai akurasi 100% dan disimpulkan hasil perhitungan sama dengan Google Maps Distance
Implementasi business intelligence dashboard untuk visualisasi data pasien posbindu ptm binaan uptd puskesmas kecamatan
Authors: Nurmalasari Dini , Nurzikriah Nurzikriah 
Published: April 2022

Posbindu PTM (integrated non-communicable disease fostered post) is a form of community participation in early detection, monitoring and early follow-up of PTM risk factors independently and continuously. The target of this program is aimed at all healthy and at-risk communities aged 15 years and over. This PTM Posbindu activity is held once a month. For Rokan IV Koto sub-district there are 10 Posbindu PTMs. After conducting the survey, the management of Puskesmas Rokan IV Koto has managed patient data using excel as a source of annual performance reporting. However, management Puskesmas Rokan IV Koto had difficulty getting information from patient data in accordance with the management's wishes. What the management of Puskesmas Rokan IV Koto wants is to know the distribution pattern of PTM, patients and patients at risk of PTM. The design of this system uses tools including: Framework CodeIgniter, PHP as a programming language and MySQL as a DBMS. This system is tested using black box testing and user acceptance test (UAT). Based on the user acceptance test (UAT) that has been carried out, it shows that 88% of the system that has been built has been accepted by the user and black box testing shows that the function has been running 100%. The benefit of this business intelligence system is that it is able to assist the head of the puskesmas in making decisions.
Keywords: Puskesmas Rokan IV Koto, Patient Data, Business Intelligence, MySQL, PHP
Systematic Literature Review Penerapan Metodologi Agile Dalam Berbagai Bidang
Authors: Zulvi Mutia sari 
Published: April 2022

Perkembangan telepon atau telepon seluler dan internet, keberadaannya memberikan pengaruh bagi berbagai aspek kehidupan. Baik kehidupan secara individu, sosial maupun yang terkait dengan dunia usaha atau bisnis. Selain mempermudah dan mempercepat proses komunikasi dan informasi, teknologi informasi juga dimanfaatkan dalam kegiatan usaha atau bisnis. Banyak alat komunikasi dan informasi yang digunakan dalam kegiatan dunia usaha, salah satunya Aplikasi. Aplikasi secara umum dibagi menjadi 3 platform yaitu desktop, web, dan mobile. Dalam membangun sebuah aplikasi, dibutuhkan metodologi pengembangan perangkat lunak yang digunakan untuk kelancaran perancangan atau pembangunan suatu aplikasi. Pengembangan aplikasi berbasis web memiliki banyak metode yang bisa digunakan, salah satunya adalah metode Agile. Metode ini merupakan salah satu metode yang terkenal karena dianggap aktual dan mudah digunakan. Penelitian ini menggunakan metode systematic literature review yang menampilkan analisis metode agile dalam berbagai bidang yang mencakup total X makalah yang diterbitkan dari tahun 2017 hingga 2021. Penelitian ini bertujuan untuk menjawab beberapa pertanyaan penelitian yaitu: 1) Mengetahui tren model apa saja yang digunakan dalam metode agile, 2) Mengetahui bidang apa saja yang mengimplementasikan metode agile dalam pengembangan aplikasinya, 3) Mengetahui platform aplikasi yang paling sering digunakan dalam metode agile. Tujuan penelitian ini adalah sebagai literatur studi terkait penggunaan Agile dan harapannya pembaca mendapatkan ilmu mengenai metode Agile apa yang akan digunakan untuk aplikasinya.

Kata Kunci: Platform, Agile, Systematic Literature Review.
Implementasi Metode LightGBM Untuk Klasifikasi Kondisi Abnormal Pada Pengemudi Sepeda Motor Berbasis Sensor Smartphone
Authors: Rachmadi R Rizki , Sudarsono Amang , Santoso Tri Budi 
Published: April 2022

Kecelakaan lalu lintas merupakan salah satu penyebab angka kematian yang cukup tinggi Dengan kondisi demografis di Indonesia, di mana pengendara sepeda motor adalah tipe yang mendominasi lalu lintas jalan raya, sehingga resiko tertimpa kecelakaan lalu lintas leboh tinggi dibanding pengendara lain. Sistem deteksi aktivitas pada kendaraan bermotor yang telah banyak dibangun umumnya terfokus pada pengemudi mobil, dan memiliki masalah utama di waktu komputasi yang tinggi. Untuk mengatasi permasalahan ini, dalam penelitian kali ini, dibuat suatu sistem deteksi aktivitas abnormal dari pengendara sepeda motor dengan menggunakan metode Light Gradient Boosting Machine (LightGBM). Sistem tersebut didesain untuk memiliki waktu komputasi yang rendah dan dapat menghasilkan respons yang cepat terhadap perubahan gerakan yang terjadi dalam kecepatan tinggi. Untuk melakukan proses pelatihan model LightGBM, akan digunakan data yang berasal dari sensor Accelerometer dan Gyroscope yang tedapat pada smartphone, yang akan digunakan untuk mendeteksi gerakan yang dilakukan oleh seorang pengendara. Model yang didapat dari proses pelatihan dengan menggunakan data yang telah dikumpulkan menunjukkan tingkat akurasi setinggi 82% pada pengetesan menggunakan data yang telah disiapkan, dan menunjukkan akurasi hampir 70% dalam proses deteksi secara real-time, dengan waktu komputasi 10 mili detik, membuktikan bahwa sistem yang didesain bekerja 5 kali lipat lebih cepat dibanding sistem yang telah ada .
Membangun Sistem Informasi Inventori CV. Muda Jeans Berbasis Website Menggunakan Metode Rapid Application Development (RAD)
Authors: Rahman Erik , Indrati Aviarini 
Published: April 2022

CV. Muda Jeans merupakan usaha milik perseorangan yang bergerak di bidang usaha jual beli dan memproduksi produk jeans wanita. Proses pencatatan dengan menuliskan setiap proses informasi tentang produk ke buku besar. Proses pencatatan tentunya masih banyak kekurangan seperti lembaran kertas buku yang mudah rusak dan hilang. Sistem ini diimplementasikan menggunakan metode Rapid Application Development (RAD) di merancang sistem. Peneliti melaksanakan persyaratan perencanaan untuk mengidentifikasi masalah dan masalah bisnis yang terjadi nanti pada tahap desain bengkel, peneliti membuat bengkel untuk menentukan alur kerja bersama sistem antarmuka dan pada tahap akhir peneliti melakukan pengujian sistem parsial pada tahap implementasi menggunakan metode pengujian kotak hitam. Peneliti ini ingin membangun sistem baru. Peneliti menghasilkan Informasi Inventaris berbasis web Sistem CV. Muda Jeans untuk membantu melakukan pencatatan produk. Kata Kunci : CV. Muda Jeans, Sistem Informasi Inventaris Berbasis Web, Aplikasi Cepat Pengembangan (RAD), pengujian black box.
Goma-laca (<i>shellac</i>): um recurso natural para revestimento e conservação de frutas
Authors: Oliveira Leone Da Purificação , Da Cruz Cátia Damasceno , Araújo Juliana Gordiano , Pereira Francine De Almeida , Pinto Laise Cedraz 
Published: April 2022

A goma-laca (shellac) é uma substância refinada e resinosa, encontrada na secreção do inseto fêmea Laccifer lacca. Sua utilização tem-se expandido na indústria de alimentos para uso como revestimento alimentar, por suas características de boa formabilidade de filme, responsividade ao pH e anfifilicidade. O objetivo deste trabalho foi revisar os dados quanto à aplicação e ao impacto da goma-laca sobre a conservação das frutas e quanto às características fisico-químicas, formas de extração e regulamentação. Esse polímero natural contribui de forma impactante para o prolongamento da vida útil pós-colheita das frutas, além disso, apresenta potencial antimicrobiano e de maior firmeza do filme, quando associado a outros compostos. As diferentes formas de extração e refino da goma-laca são simples, mas podem modificar suas caracteriscas fisico-químicas, o que ressalta a importância de atualização de dados de segurança de consumo associados a essas modificações. A abordagem do uso da goma-laca como revestimento alimentício traz bons resultados para os esforços voltados à conservação de alimentos in natura, como frutas, e ainda pode atuar como base para sistemas de embalagens ativas. O potencial de aplicação da goma- laca é amplo e contribui para a redução do desperdício e para o aumento das possibilidades de distribuição de vegetais e frutas tropicais de alta perecibilidade.