bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Conceptual Framework for Software Reliability Testing
Authors: Faiz Rizwan Bin , Rauf Abdul 
Published: July 2022

Abstract
Testing Non Functional Requirements (NFR) is critical for the success of software project. Among all NFR, software reliability testing is an ongoing challenge for software in general and safety critical systems in particular. Since software reliability, as a quality attribute, cannot be tested as a whole it therefore is decomposed in to sub factors e.g. availability, correctness, fault tolerance etc. each of which can be measured through set of metrics. One fundamental way to associate sub factors against metrics is through a conceptual framework. Existing frameworks in literature for software reliability testing have variation in sub factors and corresponding metrics through statistical evaluation. There is a need to identify and correlate sub factors and their corresponding metrics against software reliability testing. The association should be performed in a schematic way based upon empirical data gathered from target population i.e. reliability testers from global software industry. Since the conceptual framework is proposed to global software industry we therefore identified sub factors and their corresponding metrics from a sample of 81 global software reliability testing experts. All empirical data was evaluated through statistical analysis i.e. correlation and binary logistic regression. The data was also validated by a focus group of 11 experts who had up to 20 years of experience and had numerous certifications in the domain of reliability testing. A conceptual framework for reliability testing in which 33 metrics are correlated with maturity, 10 metrics are correlated with availability, 3 metrics are correlated with fault tolerance, 7 metrics are correlated with recoverability and 5 metrics are correlated with correctness are represented through a schematic relationship in hierarchical structure. A conceptual framework for reliability testing is designed which will not only facilitate in understanding of relationship between the sub factors and their corresponding metrics, it will also help in designing more effective test cases and their measurement through a set of relevant metrics. Statistical evaluation of sub factors and their corresponding metrics with reliability testing was evident through correlation analysis as their p-value < 0.05 and regression analysis since all sub factors and their corresponding metrics had positive coefficient.
Circ_0072088 mediates hepatic fibrosis renders epithelial to mesenchymal transition through miR-330-3p/CDK1 axis in AML12 hepatocytes
Authors: Liu Mengmeng , Xing Yue , Jin Yao , Liu Shuang , Teng Xue , Zhi Duo , Zhong Lu , Dong Mei 
Published: July 2022

Abstract
Hepatic fibrosis was one of the causes to hepatocellular cancer (HCC), owing to limited therapeutic options. And hepatocytes can induce liver fibrogenesis via epithelial-mesenchymal transition (EMT). Multiple circRNAs exert critical role in the occurrence of liver fibrosis via working as microRNA (miRNA) sponges. Circ_0072088 is upregulated in hepatocellular cancer (HCC) and promote proliferation, migration of HCC cells. However, the potential research mechanism for circ_0072088 action against the fibrotic progression remain still unknown. The treatment of AML12 hepatocytes with TGF-β1 contributed to dramatically increased in the levels of circ_0072088. Additionally, in terms of mechanism, circ_0072088 was authenticated to function as miR-330-3p sponge, not only noticeable increase EMT, but also induced fibrosis in AML12 hepatocytes. MiR-330-3p could weaken the roles of circ_0072088 acceleration. Moreover, we proved that CDK1, a miR-330-3p target, was time-dependently augmented in the TGF-β1 treated AML12 hepatocytes, and its overexpression weakens the miR-330-3p regulatory effects.Our findings provided a unique role of the circ_0072088 mediates hepatic fibrosis renders epithelial-mesenchymal transition at least partially through miR-330-3p/CDK1 axis, thus suggesting its tremendous therapeutic potential in the treatment of liver diseases.
A Novel Method to Detect Cyber Attacks in IoT/IIoT Devices on the Modbus Protocol using Deep Learning
Authors: Gueye Thierno , Wang Yanen , Rehman Mudassar , Mushtaq Ray Tahir 
Published: July 2022

Abstract
The dominant Intrusion Detection Models in IoT/IIoT cybersecurity use network-based datasets. This paper proposes an architecture that consistently outperforms the state-of-the-art methods of performing Intrusion Detection that includes binary classification of whether an intrusion occurred or not and multi-class classification that classifies the different types of attacks. Three neural networks are designed with and without the proposed architecture. All experiments performed in this paper conclude that the proposed architecture performs consistently better than the control neural networks. This paper shows that a neural network with an embedding function can effectively be used to model whether an attack occurred on a device and the class of attack that occurred.
Characteristics of Blood Tests in norovirus-associated Benign Convulsions with Mild Gastroenteritis in Children
Authors: Jiang Daoju , Shi Kaili , Li Suyun , Liu Guangming , Liu Zheng , Shen Jun , Li Peiqing 
Published: July 2022

Abstract
Purpose: Benign convulsions with mild gastroenteritis (CWG) is a common condition in children in Asia , and the prognosis is generally good,However, the diagnosis of CWG is an exclusive diagnosis and attention should be paid to the exclusion of potential intracranial diseases. This study analyzed the clinical features of norovirus associated CWG to provide evidence for reducing unnecessary tests.Methods:Medical records of children admitted to the Department of Emergency of Guangzhou Women and Children′s Medical Center with Stool etiology was positive for norovirus between January 2019 and January 2020 were divided into CWG group and simple gastroenteritis group ,and were reviewed and analyzed.Results:A total of 89 norovirus cases were enrolled . Age of onset, male/female ratio of CWG group and simple gastroenteritis group were 49 cases, mean 20.84 ± 5.83 months and 27:22, 40 cases, mean 19.00 ± 13.48 months and, 26:14，respectively.Serum uric acid levels in CwG and acute gastroenteritis groups increased in 43 (87.8%) and 9 (22.5%) cases, respectively. The average serum uric acid level in the CwG group was significantly higher than that in the acute gastroenteritis group (564.36±125.28umol/L vs 338.42±141.03umol/L [mean±standard deviation], p<0.0001) .The potential of hydrogen（PH）， bicarbonate（HCO3–），BE bases excess（BE），blood glucose ,Serum sodium and white blood cell(WBC) of CWG group were also lower than those of simple gastroenteritis group, the differences were statistically significant, while there were no significant differences in transaminase、residual myocardial enzymes, electrolytes and C-reactive protein(CRP ),etc.Conclusion:Children with norovirus diarrhea with recurrent convulsions, increased serum uric acid, more obvious acidosis should pay high attention to the possibility of Norovirus related CWG, lumbar puncture and Cranial imaging are unnecessary and should not be recommended.
Effect of surface termination on electronic and optical properties of lead-free tin-based eco-friendly perovskite solar cell: A first principal study
Authors: Nehra Jagdish , Kilak Mukesh , Singhal Rishi Kumar 
Published: July 2022

Abstract
The lead (Pb) based halide perovskites have been reported to be promising materials for photovoltaic applications, however, presence of toxic lead in them concerns the environmental and health issues. In this work, we have, therefore, studied the lead-free and non-toxic tin-based halide perovskite, CsSnI3, which is an eco-friendly material with high power conversion efficiency thus being a potential candidate for photovoltaic applications. We have investigated the influence of CsI and SnI2- terminated (001) surfaces on structural, electronic and optical properties of lead-free tin-based halide perovskite CsSnI3 from the first principal calculations, based on density functional theory (DFT). The calculations of electronic and optical parameters are performed under the parameterization of PBE_Sol for exchange correlation functions conjugated with modified- Beche-Johnshon (mBJ) exchange potential. The optimised lattice constant, the energy band structure and the density of states (DoS) have been calculated for the bulk and different terminated surface structures. The optical properties of CsSnI3 are computed in terms of the real and imaginary part of absorption coefficient, dielectric function, refractive index, conductivity, reflectivity, extinction coefficient and electron energy loss. The photovoltaic characteristics for CsI- termination are found to be better than the bulk and SnI2- terminated surfaces. This study reveals that optical and electronic properties can be tuned by selecting proper surface termination in halide perovskite CsSnI3. The CsSnI3 surfaces exhibit semiconductor behaviour with a direct energy band gap and a high value of absorption power in the ultraviolet and visible region rendering these inorganic halide perovskite materials important for eco-friendly and efficient optoelectronic devices.
Aptamer-conjugated graphene oxide for enrichment of microcystin-LR prior to matrix-assisted laser desorption ionization mass spectrometry
Authors: Feng Junli , Wu Yuanyuan , Song Gongshuai , Zhang Jian , Wang Qingcheng , Ling Liping , Shen Qing , Li Juanjuan 
Published: July 2022

Abstract
Microcystin-LR (MC-LR) is a cyclic heptapeptide with hepatotoxic and neurotoxic activities in mammals, which is the most widespread variant of MCs produced by cyanobacterial in eutrophic water. Here, an effective adsorbent using aptamer modified graphene oxide (GO) was designed to detect MC-LR at low concentrations. GO was functionalized with an MC-LR aptamer (Apt-3) by surface modification using polyethylene glycol (PEG). Then, the novel aptamer-conjugated GO (Apt-3/PEG/GO) was used to enrich and separate MC-LR from pond water or freshwater snail samples following by matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) analysis. Results indicated that the Apt-3/PEG/GO nanocomposites were highly specific to MC-LR, and the detection limit of MALDI-MS was 0.50 ng/mL in spiked, environmental water samples. Moreover, the MC-LR can be released from nanocomposites by heating, thus the reuse of Apt-3/PEG/GO is realized. Real samples analysis indicated that the Apt-3/PEG/GO nanocomposites coupled with MALDI-MS was efficient in detection trace amount of MC-LR in snail samples. With the merits of low cost, reusable, easy to synthesis and to flexible assembly, the Apt-3/PEG/GO nanocomposites is a novel adsorbent with extensive applications, and its combination with MALDI-MS is expected to assess other analytes by anchoring suitable aptamers for different targets.
Region Duplication Tampering Detection and Localization in digital video using Haar Wavelet Transform
Authors: J NIRMAL JOTHI , Nithila Ezhil E , X Ascar Davix 
Published: July 2022

Abstract

In today’s digital world because of the widespread availability of software tools and advancement in technology created a way for editing or modifying digital data. Availability of low cost software tools such as Adobe Premiere, Magix Vegas, Mokey by Imagineer Systems and Microsoft Movie Maker made it very easy to manipulate video content effectively. Altering the contents of digital videos became very easy because of these powerful video editing software. Video editing software is often used to copy and paste a portion of the frame from one region to another region in the same frame or another frame, in order to conceal the truth. Region duplication is one of the most common methods of video tampering. Many methodologies have been discussed by different researches to detect such tampering in digital video sequences by analyzing the spatial and temporal correlations between the pixels of the frame. However, most of the algorithms exhibit low accuracy and high computational complexity. In this paper, we are introducing a novel region duplication tampering detection technique to detect intra frame region duplication from the video sequence by means of wavelet transform and Euclidean distance. The proposed technique is evaluated using various videos where region duplication in frames introduced. From the experimental results performance of the proposed technique is evaluated in terms Precision, Recall, F1, Accuracy and computation time. Our experimental results proved that this method is highly suitable for detecting the duplicated regions in the video which is very much useful in forensic applications.
Identification of Kukoamine A as an Osteogenic Suppressor and Anti-osteoporosis Drug Target
Authors: guan Zhiyuan , Liu Shengfu , guan zhiqiang , luo liying , tao tun 
Published: July 2022

Abstract
Osteoporosis (OP) is a major and growing public health problem characterized by decreased bone mineral density and destroyed bone microarchitecture. Previous studies found that Lycium chinense Mill (LC) has a potent role in inhibiting bone loss. Kukoamine A (KuA), a bioactive compound extract from LC which was responsible for the anti-osteoporosis effect. This study aimed to investigate the anti-osteoporosis effect of KuA isolated from LC in treating OP and its potential molecular mechanism. In this study, network pharmacology and molecular docking were investigated firstly to find the active ingredients of LC such as KuA and the target genes of OP. And then, the anti-osteoporotic effect of KuA in vivo and vitro were investigated and the potential molecular mechanism including inflammation level, cell apoptosis, and oxidative stress were analyzed by dual-energy X-ray absorptiometry (DXA), micro-CT, ELISA, RT-PCR, and Western Blot. A total of 22 active compounds were screened, and we found KuA was identified as the highest active ingredient. PYGM was the target gene associated with a maximum number of active ingredients of LC and regulated KuA. In vivo, KuA treatment significantly increased the bone mineral density and bone structure which promote bone formation and inhibit bone resorption. In vitro, KuA significantly improves osteogenic differentiation and mineralization in cells experiment. In addition, KuA also attenuated inflammation levels, cell apoptosis and oxidative stress level. The results suggest that KuA could protect against the development of OP in osteoblast cells and ovariectomized OP model mice.
The Non-native Animals in China: Species Diversity, Spatial Distribution and Invasion Pattern
Authors: Peng Shuo , Wang Yannan , Wang Daimei , Li Zhihong , Xian Xiaoqing , Zhao Zihua 
Published: July 2022

Abstract
The global patterns of non-native species attract substantial concern especially due to the global changing environment. The inventory of the non-native species in a given region provides basic information for further exploration of biological invasions. We first compiled a checklist of the non-native animals in China and then analyzed their species diversity and invasion patterns. In total, 885 species of non-native animals were recorded in China, belonging to 8 phyla, 87 orders and 612 genera. Asia and North America dominated most species of non-native animals, while 125 species originated in China. The spatial distribution of non-native animals showed a decrease from coastal areas to inland regions, and inland borders had noteworthy regions (Guangxi and Xinjiang) with more records of non-native species. Additionally, the species number of non-native animals has experienced an exponential increase since 1900. Actinopterygii and Insecta were the two major groups, and Coleoptera was the largest group of Insecta. Most species of non-native insects had polyphagous and multivoltinism traits, which may be invasion indictors. Non-native animals were most likely introduced into China by stowaway and contaminant. The overview of the non-native animals in China provides comprehensive horizon of the invasion pattern, helping us to master the dynamics of non-native animals, and contributing to a balanced understanding of their global patterns.
Insights into the interaction between cadmium/ tetracycline and nano-TiO2 on a zeolite surface
Authors: Wang Teng , Meng Zhaofu , Liu Lin , Li Wenbin 
Published: July 2022

Abstract
Titanium dioxide (TiO2) nanoparticles interact with organic–inorganic pollutants in the environment, and these interactions affect their environmental behavior. The mechanisms of the interaction between TiO2 and organic–inorganic pollutants on the surface of clay minerals are still unclear. In this work, isotherm adsorption was studied to explore the interactions between Cd2+/tetracycline (TC), TiO2 nanoparticles, and a zeolite (Zeo). SEM, FT-IR, and XPS were also used to reveal the interaction mechanism between organic–inorganic pollutants and TiO2 on their stability and mobility in the environment. Compared to the single systems, the adsorption of Cd2+ and TiO2 in the Cd + TiO2 composite system decreased by 3.43% and 9.90%, respectively; the TC and TiO2 adsorption in the TC + TiO2 composite system decreased by 14.39% and 45.47%, respectively. The antagonism between Cd2+ and TiO2 was due to Cd2+ and TiO2 competing for the electrostatic attraction (-OH) and hydrogen bonding sites (Si-O), TC and TiO2 competing for the hydrogen bonding sites (-OH and C = O) on Zeo. The presence of TiO2 will increase the mobility of Cd2+ and TC on a clay surface, and this effect is more significant for organic pollutants TC. Compared with Cd2+, TC has a more significant boosting impact on the TiO2 mobility.
Associations of fertility parameters with fatty acids and DNA methylation in Mexican women undergoing in vitro fertilization
Authors: Zúñiga-Sánchez Patricia , González-Ortega Claudia , Cancino-Villarreal Patricia , Martínez-Garza Sandra , Molina-Torres Jorge , Ramírez-Chávez Enrique , Gutiérrez-Gutiérrez Antonio , Lund Gertrud , Zaina Silvio 
Published: July 2022

Abstract
Background. Fatty acids (FA) likely affect human fertility at multiple levels, as deviations from physiological FA profiles are obesogenic, and FA can modify DNA methylation (DNAm). Yet, the interplay of follicular fluid (FF) and serum FA with BMI and percentage body fat (PBF) in human fertility is not completely understood. Also, associations of DNAm with fertility are largely unexplored. Methods. Reproductive parameters ranging from retrieved oocyte number to infant birth weight, were recorded in Mexican women undergoing in vitro fertilization (n=88). Multiple regression analysis sought BMI-adjusted and age-adjusted associations. Receiver operating characteristic analysis tested for discrimination between outcomes. Results. Associations of FF and serum FA were markedly distinct. While various FF FA (C16:1, C18:0, C20:2, C20:3, arachidonic acid) were significantly and inversely associated only with retrieved oocyte number, selected serum FA were associated with a broad range of pre-fertilization and post-fertilization parameters. Associations of BMI and FF FA were complex, as arachidonic acid was inversely associated with both BMI and retrieved oocyte number, while oleic acid (OA) was directly associated with BMI and PBF. Ultrasound-assessed clinical pregnancy outcome (CP) was directly associated with serum OA but inversely with its trans isomer elaidic acid (EA) and with BMI. Compounded BMI, serum EA and OA discriminated CP well (AUC=0.74). Whole blood DNA methylation was significantly associated with and a moderate predictor (AUC=0.66) of percent fertilized oocytes.Conclusions. Overall FF FA pool composition rather than FA identity may impact oocyte production and cellular memory of FF FA is lost as the oocyte exits the follicular environment. The contrasting associations of BMI, FF OA and arachidonic acid suggest that the control of oocyte homeostasis by FF FA is uncoupled from BMI. Further studies are warranted to assess the potential of compounding BMI with serum EA and OA to predict CP.
Theoretical analysis and simulation calculation of hydrodynamic pressure pulsation effect and flow induced vibration response of radial gate structure
Authors: Zhang Bozhi , Jing Xiaochuan 
Published: July 2022

Abstract
To explore the characteristics of stochastic fluctuant water pressure acted on the surface of large radial gate and the flow-induced vibration response of the whole radial gate structure, taking a large-scale radial gate as prototype, the finite element calculation model structure of the radial gate was established to discuss the hydrodynamic pressure acting on the gate leaf with different opening, to study the dynamic pressure time curves and obtain the flow-induced vibration response by imposing hydrodynamic pressure as dynamic load. Take 10% opening of the radial gate, the results show that the hydrodynamic pressure distributed on the arc surface of the radial gate changes with the flow conditions, and the maximum pressure appears at the center of the lower edge of the gate leaf. The time history curve of fluctuating water pressure at a point can be used as the dynamic load for the flow-induced vibration analysis. The flow-induced vibration responses at the monitoring point of the radial gate structure have periodic changes in the X, Y, Z directions. The finite element simulation results are in good agreement with the theoretical calculation results, which can provide references for hydrodynamic pressure testing and flow-induced vibration response calculations.
The dominant nature of Herzberg-Teller terms in the photophysical description of naphthalene compared to anthracene and tetracene
Authors: Manian Anjay , Russo Salvy. P 
Published: July 2022

Abstract
The first order and second order corrected photoluminescence quantum yields are computed and compared to experiment for naphthalene in this manuscript discussing negative results. Results for anthracene and tetracene are recalled from previous work [J. Chem. Phys. 155, 054108 (2021)], and the results for all three polyacenes are juxtaposed to each other. While at the Franck-Condon point, each of the three noted polyacenes were found to possess a quantum yield near unity. Following the consideration of Herzberg-Teller effects, quantum yields stabilised for anthracene and tetracene to 0.19 and 0.08 respectively. Conversely, the second order corrected quantum yield for naphthalene was found to be 0.91. Analysis of this result showed that while the predicted non-radiative pathways correlate well with what should be expected, the approximation used to calculate second order corrected fluorescence, which yielded very positive results for many other molecular systems, here is unable to account for strong second order contributions, resulting in a grossly overestimated rate of fluorescence. However, substitution of an experimental radiative rate results in a quantum yield of 0.33. This work extols the importance of Herzberg-Teller terms in photophysical descriptions of chromophores, and highlights those cases in which a treatment beyond the above approximation is required.