bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical Compositions in Modified Salinity Waterflooding of Calcium Carbonate Reservoirs: Experiment
Authors: Yutkin M. P. , Radke C. J. , Patzek T. W. 
Published: January 2022

AbstractModified or low-salinity waterflooding of carbonate oil reservoirs is of considerable economic interest because of potentially inexpensive incremental oil production. The injected modified brine changes the surface chemistry of the carbonate rock and crude oil interfaces and detaches some of adhered crude oil. Composition design of brine modified to enhance oil recovery is determined by labor-intensive trial-and-error laboratory corefloods. Unfortunately, limestone, which predominantly consists of aqueous-reactive calcium carbonate, alters injected brine composition by mineral dissolution/precipitation. Accordingly, the rock reactivity hinders rational design of brines tailored to improve oil recovery. Previously, we presented a theoretical analysis of 1D, single-phase brine injection into calcium carbonate-rock that accounts for mineral dissolution, ion exchange, and dispersion (Yutkin et al. in SPE J 23(01):084–101, 2018. 10.2118/182829-PA). Here, we present the results of single-phase waterflood-brine experiments that verify the theoretical framework. We show that concentration histories eluted from Indiana limestone cores possess features characteristic of fast calcium carbonate dissolution, 2:1 ion exchange, and high dispersion. The injected brine reaches chemical equilibrium inside the porous rock even at injection rates higher than 3.5 $$\times$$
×
10$$^{-3}$$

-
3

m s$$^{-1}$$

-
1

(1000 ft/day). Ion exchange results in salinity waves observed experimentally, while high dispersion is responsible for long concentration history tails. Using the verified theoretical framework, we briefly explore how these processes modify aqueous-phase composition during the injection of designer brines into a calcium-carbonate reservoir. Because of high salinity of the initial and injected brines, ion exchange affects injected concentrations only in high surface area carbonates/limestones, such as chalks. Calcium-carbonate dissolution only affects aqueous solution pH. The rock surface composition is affected by all processes.
Investigating potential hydrological ecosystem services in urban gardens through soil amendment experiments and hydrologic models
Authors: Chapman Eric J. , Small Gaston E. , Shrestha Paliza 
Published: January 2022

AbstractAmong the ecosystem services provided by urban greenspace are the retention and infiltration of stormwater, which decreases urban flooding, and enhanced evapotranspiration, which helps mitigate urban heat island effects. Some types of urban greenspace, such as rain gardens and green roofs, are intentionally designed to enhance these hydrologic functions. Urban gardens, while primarily designed for food production and aesthetic benefits, may have similar hydrologic function, due to high levels of soil organic matter that promote infiltration and water holding capacity. We quantified leachate and soil moisture from experimental urban garden plots receiving various soil amendments (high and low levels of manure and municipal compost, synthetic fertilizer, and no inputs) over three years. Soil moisture varied across treatments, with highest mean levels observed in plots receiving manure compost, and lowest in plots receiving synthetic fertilizer. Soil amendment treatments explained little of the variation in weekly leachate volume, but among treatments, high municipal compost and synthetic fertilizer had lowest leachate volumes, and high and low manure compost had slightly higher mean leachate volumes. We used these data to parameterize a simple mass balance hydrologic model, focusing on high input municipal compost and no compost garden plots, as well as reference turfgrass plots. We ran the model for three growing seasons under ambient precipitation and three elevated precipitation scenarios. Garden plots received 12–16% greater total water inputs compared to turfgrass plots because of irrigation, but leachate totals were 20–30% lower for garden plots across climate scenarios, due to elevated evapotranspiration, which was 50–60% higher in garden plots. Within each climate scenario, difference between garden plots which received high levels of municipal compost and garden plots which received no additional compost were small relative to differences between garden plots and turfgrass. Taken together, these results indicate that garden soil amendments can influence water retention, and the high-water retention, infiltration, and evapotranspiration potential of garden soils relative to turfgrass indicates that hydrologic ecosystem services may be an underappreciated benefit of urban gardens.
Inhibition of phosphorylated calcium/calmodulin-dependent protein kinase IIα relieves streptozotocin-induced diabetic neuropathic pain through regulation of P2X3 receptor in dorsal root ganglia
Authors: He Xiao-fen , Kang Yu-rong , Fei Xue-yu , Chen Lu-hang , Li Xiang , Ma Yi-qi , Hu Qun-qi , Qu Si-ying , Wang Han-zhi , Shao Xiao-mei , Liu Bo-yi , Yi-Liang  , Du Jun-Ying , Fang Jian-qiao , Jiang Yong-liang 
Published: January 2022

Abstract Diabetic neuropathic pain (DNP) is frequent among patients with diabetes. We previously showed that P2X3 upregulation in dorsal root ganglia (DRG) plays a role in streptozotocin (STZ)-induced DNP but the underlying mechanism is unclear. Here, a rat model of DNP was established by a single injection of STZ (65 mg/kg). Fasting blood glucose was significantly elevated from the 1st to 3rd week. Paw withdrawal thresholds (PWTs) and paw withdrawal latencies (PWLs) in diabetic rats significantly reduced from the 2nd to 3rd week. Western blot analysis revealed that elevated p-CaMKIIα levels in the DRG of DNP rats were accompanied by pain-associated behaviors while CaMKIIα levels were unchanged. Immunofluorescence revealed significant increase in the proportion of p-CaMKIIα immune positive DRG neurons (stained with NeuN) in the 2nd and 3rd week and p-CaMKIIα was co-expressed with P2X3 in DNP rats. KN93, a CaMKII antagonist, significantly reduce mechanical hyperalgesia and thermal hyperalgesia and these effects varied dose-dependently, and suppressed p-CaMKIIα and P2X3 upregulation in the DRGs of DNP rats. These results revealed that the p-CaMKIIα upregulation in DRG is involved in DNP, which possibly mediated P2X3 upregulation, indicating CaMKIIα may be an effective pharmacological target for DNP management.
Self-efficacy and behavior patterns of learners using a real-time collaboration system developed for group programming
Authors: Hsu Ting-Chia , Abelson Hal , Patton Evan , Chen Shih-Chu , Chang Hsuan-Ning 
Published: January 2022

AbstractIn order to promote the practice of co-creation, a real-time collaboration (RTC) version of the popular block-based programming (BBP) learning environment, MIT App Inventor (MAI), was proposed and implemented. RTC overcomes challenges related to non-collocated group work, thus lowering barriers to cross-region and multi-user collaborative software development. An empirical study probed into the differential impact on self-efficacy and collaborative behavior of learners in the environment depending upon their disciplinary background. The study serves as an example of the use of learning analytics to explore the frequent behavior patterns of adult learners, in this case specifically while performing BBP in MAI integrated with RTC. This study compares behavior patterns that are collaborative or individual that occurred on the platform, and investigates the effects of collaboration on learners working within the RTC depending on whether they were CS-majors or not. We highlight advantages of the new MAI design during multi-user programming in the online RTC based on the connections between the interface design and BBP as illustrated by two significant behavior patterns found in this instructional experiment. First, the multi-user programming in the RTC allowed multiple tasks to happen at the same time, which promoted engagement in joint behavior. For example, one user arranged components in the interface design while another dragged blocks to complete the program. Second, this study confirmed that the Computer Programming Self-Efficacy (CPSE) was similar for individual and multi-user programming overall. The CPSE of the homogeneous CS-major groups engaged in programming within the RTC was higher than that of the homogeneous non-CS-major groups and heterogeneous groups. There was no significant difference between the CPSE of the homogenous non-CS group and the CPSE of the heterogeneous groups, regardless of whether they were engaged in individual programming or collaborative programming within their groups. The results of the study support the value of engaging with MAI collaboratively, especially for CS-majors, and suggest directions for future work in RTC design.
Effect of Nucleant Particle Agglomeration on Grain Size
Authors: Gao Feng , Fan Zhongyun 
Published: January 2022

Abstract
Solute accumulation/depletion in the liquid around a growing solid particle during the solidification of metallic melts creates a constitutionally supercooled (CS) zone that has a significant effect on the final solidified grain structure. In this paper, we introduce two mechanisms related to the CS zone that affect grain size: one is the grain initiation free zone (GIFZ) that describes the inability of nucleant particles located in the CS zone for grain initiation and the other is re-melting (RM) of solid particles due to overlap of CS zones. Based on these two mechanisms, we have systematically analysed the effect of nucleant particle agglomeration on grain size. We found that nucleant particle agglomeration has a significant effect on grain size and is responsible for the discrepancy between theoretically predicted grain size and the experimental data. In addition, our numerical analysis suggests that under normal solidification conditions relevant to industrial practice solid particle re-melting has little effect on grain size and thus may be ignored during theoretical analysis. A practical implication from this work is that significant grain refinement can be achieved by dispersing the nucleant particles in the melt prior to solidification.
Decoupling the Impacts of Strain Rate and Temperature on TRIP in a Q&P Steel
Authors: Finfrock Christopher B. , Bhattacharya Diptak , McBride Brady N. L. , Ballard Trevor J. , Clarke Amy J. , Clarke Kester D. 
Published: January 2022

AbstractThe individual effects of strain rate and temperature on the strain hardening rate of a quenched and partitioned steel have been examined. During quasistatic tests, resistive heating was used to simulate the deformation-induced heating that occurs during high-strain-rate deformation, while the deformation-induced martensitic transformation was tracked by a combination of x-ray and electron backscatter diffraction. Unique work hardening rates under various thermal–mechanical conditions are discussed, based on the balance between the concurrent dislocation slip and transformation-induced plasticity deformation mechanisms. The diffraction and strain hardening data suggest that the imposed strain rate and temperature exhibited dissonant influences on the martensitic phase transformation. Increasing the strain rate appeared to enhance the martensitic transformation, while increasing the temperature suppressed the martensitic transformation.
Validity of the γ-Ray Evaluation with iodoamphetamine for Cerebral Blood Flow Assessment (REICA) method for quantification of cerebral blood flow including acetazolamide challenge test
Authors: Miyazaki Yoshiaki , Kameyama Masashi , Nakamizo Akira , Noguchi Tomoyuki , Tabata Nobuyuki 
Published: January 2022

Abstract
Objective
The γ-Ray Evaluation with iodoamphetamine for Cerebral Blood Flow Assessment (REICA) is a new method for quantifying cerebral blood flow (CBF) using single-photon emission computed tomography (SPECT) and [123I]N-isopropyl-p-iodoamphetamine (123I-IMP). The present study aimed to validate the REICA method using data including acetazolamide challenge test.

Methods
The REICA and Graph-Plot (GP) methods were used to calculate mean CBF (mCBF) for 92 acquisitions (rest: 57, stress: 35) and cerebrovascular reactivity (CVR) in 33 patients. To obtain stress data, 15 mg/kg of acetazolamide was injected intravenously 10 min before the administration of 123I-IMP, and blood samples were collected under the same conditions as rest data. The reference standard was the Autoradiograph (ARG) method using arterial blood sampling, and the accuracy of the REICA method was analyzed by comparing it with each method.

Results
For mCBF, the correlation coefficients (r) were 0.792 for the REICA method and 0.636 for the GP method. For CVR, r values were 0.660 for the REICA method and 0.578 for the GP method. In both acquisitions, the REICA method had a stronger correlation with the ARG method than the GP method. For mCBF, there was a significant difference in the correlation coefficient between the two correlation coefficients (p < 0.01).

Conclusions
The REICA method was more accurate than the GP method in quantifying CBF and closer to the ARG method. The REICA method, which is a noninvasive method of cerebral blood flow quantification using 123I-IMP, has great medical usefulness.
Association between HLA alleles and sub-phenotype of childhood steroid-sensitive nephrotic syndrome
Authors: Lee Hao , Wang Li , Ni Fen-Fen , Yang Xue-Ying , Feng Shi-Pin , Gao Xiao-Jie , Chi Huan , Luo Ye-Tao , Chen Xue-Lan , Yang Bao-Hui , Wan Jun-Li , Jiao Jia , Wu Dao-Qi , Zhang Gao-Fu , Wang Mo , Yang Hai-Ping , Chan Han , Li Qiu 
Published: January 2022

Abstract
Background
Few studies have addressed the effects of human leukocyte antigen (HLA) alleles on different clinical sub-phenotypes in childhood steroid-sensitive nephrotic syndrome (SSNS), including SSNS without recurrence (SSNSWR) and steroid-dependent nephrotic syndrome/frequently relapse nephrotic syndrome (SDNS/FRNS). In this study, we investigated the relationship between HLA system and children with SSNSWR and SDNS/FRNS and clarified the value of HLA allele detection for precise typing of childhood SSNS.

Methods
A total of 241 Chinese Han individuals with SSNS were genotyped using GenCap-WES Capture Kit, and four-digit resolution HLA alleles were imputed from available Genome Wide Association data. The distribution and carrying frequency of HLA alleles in SSNSWR and SDNS/FRNS were investigated. Additionally, logistic regression and mediating effects were used to examine the relationship between risk factors for disease process and HLA system.

Results
Compared with SSNSWR, significantly decreased serum levels of complement 3 (C3) and complement 4 (C4) at onset were detected in SDNS/FRNS (C3, P < 0.001; C4, P = 0.018). The average time to remission after sufficient initial steroid treatment in SDNS/FRNS was significantly longer than that in SSNSWR (P = 0.0001). Low level of C4 was further identified as an independent risk factor for SDNS/FRNS (P = 0.008, odds ratio = 0.174, 95% confidence interval 0.048–0.630). The HLA-A*11:01 allele was independently associated with SSNSWR and SDNS/FRNS (P = 0.0012 and P = 0.0006, respectively). No significant HLA alleles were detected between SSNSWR and SDNS/FRNS. In addition, a mediating effect among HLA-I alleles (HLA-B*15:11, HLA-B*44:03 and HLA-C*07:06), C4 level and SDNS/FRNS was identified.

Conclusions
HLA-I alleles provide novel genetic markers for SSNSWR and SDNS/FRNS. HLA-I antigens may be involved in steroid dependent or frequent relapse in children with SSNS as mediators of immunoregulation.
Konzeptualisierung und Messung der Qualität der adaptiven Lernunterstützung in Lernsituationen mit mathematischen Regelspielen im Kindergarten. Eine Studie in Deutschland und der Schweiz
Authors: Meier-Wyder Anuschka , Wullschleger Andrea , Lindmeier Anke , Heinze Aiso , Leuchter Miriam , Vogt Franziska , Moser Opitz Elisabeth 
Published: January 2022

ZusammenfassungDie Qualität der adaptiven Lernunterstützung ist wichtig für die Förderung des mathematischen Lernens von Kindergartenkindern. Entsprechend bedarf es geeigneter Instrumente zur Bewertung der Planung, Durchführung und Reflexion von mathematischen Lernangeboten im Kindergarten. Bestehende Instrumente berücksichtigen vor allem die mikro-adaptive (mathematische) Lernunterstützung, die den Fokus auf die Interaktion zwischen der Fachkraft und den Kindern legt. Die Qualität der makro-adaptiven (mathematischen) Lernunterstützung (Planung und Reflexion von Lernsituationen) wurde im Kindergarten bis jetzt noch nicht umfassend untersucht. Sie gewinnt jedoch im Hinblick auf die zunehmende Bedeutung von Bildungsplänen im Kindergarten und der damit verbundenen Förderung von fachbezogenen Kompetenzen an Bedeutung.Im Artikel wird erstens die Qualität von (mathematischer) Lernunterstützung in Regelspielsituationen im Kindergarten konzeptualisiert. Dabei wird die Qualität der makro-adaptiven von der mikro-adaptiven Lernunterstützung unterschieden. Letztere wird getrennt in fachunabhängige Unterstützungsqualität (Gruppenmanagement, emotionale Wärme) und in instruktionale, mathematikbezogene Unterstützungsqualität (Lernanregung, Verwendung Fachsprache). Zweitens wird ein Messinstrument (Rating) zur Analyse der Qualität der Lernunterstützung in mathematischen Lernsituationen vorgestellt. Dieses wurde zur Analyse von videografierten Regelspielsituationen und anschließenden Leitfadeninterviews von 145 pädagogischen Fachkräften aus Deutschland und der Schweiz eingesetzt. Pro Fachkraft standen zwei Videosequenzen und zwei Interviews zur Verfügung. Auf der Basis dieser Daten wird das Messinstrument hinsichtlich verschiedener Gütekriterien sowie des Einflusses der Ausbildung der Fachkräfte (akademisch, nicht akademisch) und des Bildungskontextes (Deutschland, Schweiz) analysiert. Die theoretisch angenommene Unterscheidung von Gruppenmanagement, emotionaler Wärme und instruktionaler Unterstützungsqualität lässt sich durch eine konfirmatorische Faktorenanalyse stützen. Die Ergebnisse bestätigen die Bedeutung des Einbezugs von Planung und Reflexion als Dimensionen von adaptiver Lernunterstützungsqualität.
The Role of miRNA in Ovarian Cancer: an Overview
Authors: Zhao Lihui , Liang Xiaolei , Wang Liyan , Zhang Xuehong 
Published: January 2022

AbstractOvarian cancer (OC) is a highly malignant disease that seriously threatens women’s health and poses challenges for clinicians. MicroRNAs (miRNAs) have recently been intensively studied in the field of oncology due to their regulatory roles in gene expressions through RNA degradation and/or translation inhibition. This review summarizes the current studies on miRNAs in OC and introduces the latest updates of miRNAs in the early screening, treatment, and prognostic prediction of OC, thereby demonstrating the clinical significance of miRNAs in OC. Further exploration on potential targets of miRNAs in OC may provide new insights on optimizing the diagnosis and treatment of OC. MiRNAs are important driving factors for the progression of OC and the dysregulation of miRNAs can serve as biomarkers in the diagnosis, treatment and prognosis of OC. Therefore, miRNAs are potential biological targets for early screening, targeted therapy, drug resistance monitoring, and prognosis improvement in malignancies such as OC.
Seven-year trajectories of body weight, quality of life and comorbidities following Roux-en-Y gastric bypass and sleeve gastrectomy
Authors: Nielsen Hans Jørgen , Nedrebø Bjørn Gunnar , Fosså Alexander , Andersen John Roger , Assmus Jörg , Dagsland Vigdis Halvorsen , Dankel Simon Nitter , Gudbrandsen Oddrun Anita , Fernø Johan , Hjellestad Iren , Hjermstad Marianne Jensen , Kolotkin Ronette L. , Thorsen Håvard Luong , Mellgren Gunnar , Flølo Tone Nygaard 
Published: January 2022

Abstract
Background/objectives
There is limited long-term data comparing the outcomes of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) for severe obesity, both with respect to body weight, quality of life (QOL) and comorbidities.
We aimed to determine 7-year trajectories of body mass index (BMI), QOL, obesity-related comorbidities, biomarkers of glucose and lipid metabolism, and early major complications after SG and RYGB.

Subjects/methods
Patients scheduled for bariatric surgery at two Norwegian hospitals, preferentially performing either SG or RYGB, were included consecutively from September 2011 to February 2015.
Data was collected prospectively before and up to 7 years after surgery. Obesity-specific, generic and overall QOL were measured by the Impact of Weight on Quality of Life-Lite, Short-Form 36 and Cantril’s ladder, respectively. Comorbidities were assessed by clinical examination, registration of medication and analysis of glucose and lipid biomarkers. Outcomes were examined with linear mixed effect models and relative risk estimates.

Results
Of 580 included patients, 543 (75% women, mean age 42.3 years, mean baseline BMI 43.0 kg/m2) were operated (376 SG and 167 RYGB). With 84.2% of participants evaluable after 5–7 years, model-based percent total weight-loss (%TWL) at 7 years was 23.4 after SG versus 27.3 after RYGB (difference 3.9%, p = 0.001). All levels of QOL improved similarly after the two surgical procedures but remained below reference data from the general population at all timepoints. Remission rates for type 2 diabetes, dyslipidemia, obstructive sleep-apnea and gastroesophageal reflux disease (GERD) as well as the rate of de novo GERD significantly favored RYGB. SG had fewer major early complications, but more minor and major late complications combined over follow-up.

Conclusion
In routine health care, both SG and RYGB are safe procedures with significant long-term weight-loss, improvement of QOL and amelioration of comorbidities. Long-term weight-loss and remission rates of main obesity-related comorbidities were higher after RYGB.
Sensitivity and reliability of screening measures for paternal postpartum depression: an integrative review
Authors: Kennedy Erin , Munyan Kristen 
Published: January 2022

AbstractThe American Academy of Pediatrics (AAP) recommends screening mothers for Postpartum Depression (PPD) during the postpartum period. Research shows depression in parents is associated with impaired growth and development in their children. The National Perinatal Association (NPA) encourages screening fathers for depression at least twice during the first postpartum year, however a preferred screening tool has yet to be determined. To promote optimal outcomes for children, providers must assess the mental health of all new parents, regardless of gender. Therefore, the purpose of this integrative review is to examine previous scientific evidence regarding the sensitivity of screening measures for postpartum depression in fathers. Future research should be directed towards describing the psychometric properties of a tool to assess postpartum mood disorders in American fathers while analyzing appropriate screening intervals during the postpartum period.