bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uji Kompatibilitas Beauveria bassiana (Balsamo) Vuillemin dan Insektisida Nabati Ekstrak Daun Mimba Terhadap Larva Spodoptera exigua (Hubner)
Authors: Prastiwi Santi , Hartatik Sri 
Published: November 2022

Penelitian ini bertujuan untuk menguji kompatibilitas antara cendawan entomopatogen Beauveria bassiana (BB) dan insektisida nabati ekstrak daun mimba (EDM) terhadap larva Spodoptera exigua yang ditinjau dari mortalitas dan nilai toksisitas. Penelitian ini terdiri dari pengujian tunggal BB dan EDM, serta pengujian kombinasi menggunakan Rancangan Acak Lengkap (RAL) 6 perlakuan 4 kali ulangan. Mortalitas larva S.exigua diamati hingga mencapai mortalitas ±90%. Data mortalitas larva diolah dengan analisis probit Finney (1971). Hasil Pengujian tunggal menunjukkan mortalitas perlakuan BB 0,2% dan EDM 5% pada 7 HSP adalah 79,17% dan 91,67%, sedangkan pada 8 HSP sebesar 89,58% dan 95,83%. Mortalitas pengujian kombinasi BB dengan EDM (1:10 w/w) 0,66% pada 7 HSP adalah 91,67%, sedangkan pada 8 HSP 97,92%. Nilai LC50 pengujian tunggal BB pada 7 HSP dan 8 HSP adalah 0,08% (0,06%-0,1%) dan 0,06% (0,05%-0,07%). Nilai LC50 pengujian tunggal EDM pada 7 HSP dan 8 HSP adalah 0,70% (0,54%-0,91%) dan 0,58% (0,45%-0,75%). Nilai LC50 perlakuan kombinasi BB dengan EDM pada 7 HSP dan 8 HSP adalah 0,07% (0,06%-0,10%) dan 0,05% (0,03%-0,06%). Nilai LT50 BB, EDM, dan kombinasinya pada konsentrasi tertinggi sampai konsentrasi terendah berturut-turut 5,20-12,50 hari; 4,68-9,41 hari; dan 4,65-8,28 hari. Kombinasi BB dengan EDM memiliki indeks kombinasi <0,5 yang membuktikan bahwa pengombinasian memberikan efek sinergistik atau kompatibel.

Kata Kunci: Kompatibilitas, Beauveria bassiana, Ekstrak daun mimba, Spodoptera exigua
PEMANFAATAN LIMBAH KULIT NANAS DAN ECENG GONDOK SEBAGAI PUPUK ORGANIK CAIR TERHADAP PERTUMBUHAN DAN HASIL TANAMAN KANGKUNG DARAT (Ipomoea reptans Poir.)
Authors: Rosita Hanifa Devi , Regar Arthur Frans Cesar 
Published: November 2022

Limbah kulit nanas adalah limbah yang dihasilkan dari sisa pembuangan produksi buah nanas. Limbah kulit nanas mengandung nitrogen total sebanyak 0,88%. Unsur nitrogen ini nantinya akan membantu merangsang pertumbuhan pada tanaman terutama pada pertumbuhan vegetatif seperti pada daun tanaman. Eceng gondok merupakan salah satu gulma yang hidup dipermukaan air dengan cara mengapung. Populasinya akan meningkat 3% per hari ketika musim hujan tiba. Eceng gondok dapat digunakan sebagai POC karena eceng gondok segar mengandung C organik 21,23%, bahan organik 36,59%, P total 0,0011%, N total 0,28%, dan K total 0,016%. POC kulit nanas kombinasi eceng gondok nantinya akan di aplikasikan pada tanaman kangkung darat. Pembuatan POC kulit nanas kombinasi eceng gondok dibedakan pada perbedaan bahan POC. Perbedaan bahan POC dibedakan menjadi tiga yaitu kulit nanas, eceng gondok, serta kombinasi kulit nanas dan eceng gondok yang kemudian akan di fermentasi selama 30 hari. Variabel pengamatan pada penelitian ini yaitu tinggi tanaman, jumlah daun, panjang akar, berat basah (akar, tajuk dan total), dan berat kering (akar, tajuk dan total). Rancangan percobaan dilakukan dengan RAL dengan satu faktor yaitu perbedaan kombinasi bahan POC dengan 4 perlakuan dan masing-masing perlakuan diulang sebanyak 5 ulangan. Data hasil pengamatan selanjutnya akan dianalisis menggunakan Analisis Ragam Lanjutan, data hasil pengamatan dilakukan uji BNJ (Beda Nyata Jujur) pada taraf kepercayaan 95%. Penelitian POC ini diharapkan berpengaruh nyata terhadap respon pertumbuhan kangkung darat (Ipomea reptans Poir.). Berdasarkan hasil penelitian menunjukan bahwa pemberian dari ketiga jenis pupuk organik cair yang paling berpengaruh terhadap pertumbuhan dan hasil tanaman kangkung darat yaitu pupuk organik cair dengan bahan kulit nanas dan eceng gondok.
Kata Kunci : Kangkung Darat, Pupuk Organik Cair, Kulit Nanas, Eceng Gondok
PENGARUH INDUKSI MUTASI DENGAN MUTAGEN EMS (ETHYL METHANE SULFONATE) TERHADAP HASIL DAN KUALITAS KEDELAI HITAM (Glycine soja (L) Merrit)
Authors: Laksono Febrian Puji , Fanata Wahyu Indra Duwi 
Published: November 2022

Tanaman kedelai merupakan salah satu jenis tanaman yang menjadi sektor perekonomian Indonesia di bidang pertanian. Permintaan kedelai di Indonesia terus meningkat tiap tahunnya bersamaan dengan peningkatan jumlah penduduk. Banyaknya permintaan akan tanaman kedelai belum dapat terpenuhi akibat rendahnya produktivitas tanaman kedelai tersebut. Penilitian ini bertujuan untuk mengetahui pengaruh konsentrasi mutagen EMS terhadap kualitas hasil produksi pada tanaman kedelai hitam. Manfaat dari penelitian ini adalah memperoleh informasi mengenai pengaruh konsentrasi mutagen EMS terhadap kualitas dan hasil produksi pada tanaman kedelai hitam. Penelitian ini menggunakan perlakuan yaitu konsentrasi EMS dengan lama perendaman benih selama 3 jam. Faktor konsentrasi EMS (P) dengan 4 taraf perlakuan: P0 : EMS dengan konsentrasi 0,00% (kontrol),P1 : EMS dengan konsentrasi 0,03%, P2 : EMS dengan konsentrasi 0,05%, P3 : EMS dengan konsentrasi 0,07%. Terdapat 4 perlakuan yang masing-masing perlakuan di ulang sebanyak 25 kali sehingga total satuan percobaan sebanyak 100 satuan percobaan dengan tiap polibag terdapat 1 tanaman. Hasil Penelitian selanjutnya dilakukan analisis data. Analisis data menggunakan metode analisis deskriptif kunatitatif. Data yang disajikan berupa data kuantitatif dan dideskripsikan menggunakan kata-kata.
Kata kunci: Tanaman Kedelai Hitam, Mutasi Tanaman, Ethyil Methane Sulfonate.
RESPON KERAGAAN DAN PRODUKTIVITAS TANAMAN CABAI BESAR (Capsicum annuum L.) TERHADAP KONSENTRASI LARUTAN SODIUM AZIDA
Authors: Sari Novita Indah Kartika , Fanata Wahyu Indra Duwi 
Published: November 2022

ABSTRAK
Cabai besar merupakan salah satu tanaman hortikultura yang memiliki nilai ekonomi yang cukup tinggi di Indonesia. Harga cabai besar, sering kali mengalami kenaikan terutama pada saat hari hari besar. Salah satu yang dapat dilakukan untuk meningkatkan produktivitas cabai besar yaitu dengan menghasilkan kultivar baru yang unggul. Hal yang dapat dilakukan untuk menghasilkan kultivar baru yaitu dapat menggunakan perlakuan mutasi. Perlakuan mutasi yang digunakan dalam penelitian ini yaitu mutasi kimia dengan menggunakan larutan Sodium Azida (NaN3). Perlakuan mutasi Sodium Azida (NaN3) yang digunakan yaitu dengan konsentrasi 0,75mM dan konsentrasi 1,5mM. Penelitian ini dilakukan dengan tujuan untuk mendapatkan tanaman cabai besar (Capsicum annuum L) yang mampu berproduksi lebih tinggi dan untuk mempelajari pengaruh konsentrasi Sodium Azida terhadap keragaan dan produktivitas tanaman cabai besar (Capsicum annuum L). Manfaat dari penelitian ini yaitu untuk memberikan pengetahuan tambahan dibidang pertanian khususnya mengenai tanaman cabai besar yang diberi Sodium Azide, serta menjadi tambahan literatur bagi penelitian selanjutnya. Penelitian dilaksanakan di greenhouse Desa Lojajar Kecamatan Tenggarang Kabupaten Bondowoso. Bahan yang digunakan meliputi benih cabai varietas Astina, larutan sodium azide (SA). Metode penelitian yang digunakan yaitu menggunakan Rancangan Acak Lengkap (RAL) dengan 3 perlakuan dan 15 kali ulangan hingga terdapat 45 kombinasi perlakuan diantaranya kontrol, perlakuan sodium azide 0,75mM, dan perlakuan sodium azide 1,5mM lalu uji lanjut dengan menggunakan BNJ dengan taraf 5%. Hasil analisis ragam dapat diketahui bahwa sodium azide dengan perlakuan 0mM, 0,75mM, 1,5mM menunjukan bahwa perlakuan sodium azide 1,5mM dapat memberikan hasil terbaik dibandingan dengan perlakuan P0 (kontrol) dan perlakuan P1(Sodium azide 0,75mM) serta memberikan pengaruh positif terhadap jumlah cabang aktif yaitu sebesar 19 cabang, jumlah bunga sebesar 25 bunga, jumlah buah sebesar 20 buah dan berat buah sebesar 155,73 gram per tanaman. Namun perlakuan P0 (kontrol), P1(0,75mM), P2 (1,5mM) tidak memberikan pengaruh nyata terhadap kandungan klorofil.
Kata Kunci : Cabai Besar, Mutasi Gen, Sodium Azide(ZA)
Evaluations of the predistortion technique by neural network algorithm in MIMO-OFDM system using USRP
Authors: Gunawan M Wisnu , Priambodo Naufal Ammar , Gulo Melki Mario , Arifin Arifin , Moegiharto Yoedy , Briantoro Hendy 
Published: November 2022

MIMO OFDM is the key technology of 4G network system. MIMO-OFDM system enhances the spectrum efficiency and increases the capacity of the system. The implementation of USRP hardware to MIMO OFDM system has been attracted some researchers to conduct the experiments. So we conduct the experiments in a MIMO OFDM system that applies the predistortion technique. In this experiment, we evaluate performances of the predistortion technique by using the artificial neural network. USRP 2920 hardware which is supported by LabVIEW and Phyton software are used in this experiment. OFDM system uses 128 subcarriers to produce an OFDM symbol, and MIMO system uses 2 antennas at transmitter and receiver side. And no obstacles between Tx and Rx, or line of sight transmission scenarios. The performances of the predistortion technique using the artificial neural network algorithm are shown in symbol constellations or Error Vector Magnitude (EVM) at the receiver. And the texts or characters are used as the input of the system. From the experiment results can be seen that the distance between Tx and Rx affects the Error Vector Magnitude (EVM) and predistortion technique produces the Error vector magnitude (EVM) improvement. More shorter the distance between Tx and Rx can decrease distortions of the received signal, At the transmitter side, the performance of predistortion technique is shown as the linearization improvement of the non-linearity power amplifier. Therefore more wider the linear region of power amplifier results the decreasing in band distortion of transmitted signal, and can be seen as the Error Vector Magnitude (EVM) improvement.
Thrombodynamics Test in Assessing the Risk of Thrombus Formation in Patients with Atrial Fibrillation Taking Direct Oral Anticoagulants
Authors: Gebekova Z. A. , Ivanov I. I. , Asambayeva A. , Skripka A. I. , Sokolova A. A. , Napalkov D. A. , Vuimo T. A. 
Published: November 2022

Aim. To evaluate thrombus characteristics in patients with atrial fibrillation (AF) taking different direct oral anticoagulants (DOACs) using Thrombodynamics test.Materials and methods. Thrombodynamics test was performed in 100 patients with paroxysmal and permanent forms of AF taking different DOACs, dose choice was done in accordance with the instructions for drugs use. For analysis samples of fresh citrated platelet-free plasma were taken just before regular DOACs dose intake (trough concentration). Statistical data processing was carried out using R software packages.Results. All patients had no history of thrombosis or bleeding before inclusion in this study. All parameters of Thrombodynamics test taken at residual concentration of DOACs were in general within reference values, that is in the area of normal coagulation: spatial clot growth rate (V) – 26.56 (25.0; 29.2) μm/min, the time to the start of clot growth (Tlag) – 1.05 (0.85; 1.27) min, initial spatial clot growth rate (Vi) – 44.3±7.7 μm/min, stationary spatial clot growth rate (Vst) – 26.5 (24.9; 28.4) μm/min, clot size (CS) – 999.7 (912.9; 1084.7) μm, clot density (D) – 22883.1±3199.9 arb. units. D was appeared to be higher in women [22947.7 (21477.5; 22947.7) vs men [22124.8 (19722.8; 22124.8), p=0.035] and Tlag was significantly higher in patients with chronic heart failure [1.2 (1.0; 1.2) vs 1.0 (0.8; 1.0), p=0.008]. A correlation was found between level of creatinine and Tlag parameter, glomerular filtration rate (GFR) and clot density. With an increase in the level of creatinine in the blood and a decrease in GFR, respectively, there was an increase in Tlag parameter (p-value 0.038); with an increase in GFR, clot density decrease (p-value 0.005).Conclusion. All parameters of Thrombodynamics test on residual concentration of DOACs were within reference values that indicated optimal anticoagulant effect of all DOACs. The obtained data of normal coagulation at the residual concentration of the anticoagulant are consistent with the previously obtained data on the safety and effectiveness of DOACs using other methods. Further studies with clinical end points are needed to assess the clinical value of this method.
Study on Fatigue Behavior of S135 Steel and Titanium Alloy Drillpipes: Experiment and Modeling
Authors: Peng Xianbo , Yu Hao , Lian Zhanghua , Liu Tao , Shi Junlin , Yang Dongchuan 
Published: November 2022

Summary
This paper studies the fatigue failure behavior of S135 steel and titanium alloy drillpipe, tries to reveal the mechanism of fatigue fracture, and evaluates the degree of fatigue damage. First, the chemical composition, tensile test, and microstructure analysis of two types of pipes were carried out, and the difference in microstructure affects its macroscopic fatigue performance. Second, the stress vs. fatigue life (S-N) curve equation and fatigue limit of S135 steel and titanium alloy drillpipes in air and mud were obtained through the fatigue test. The equations of the S-N curves in air are NS135−air=9.45×1037(S+1776)−9.3 and NTi−air=1.41×1028(S+1124)−6.7, while in mud, they are NS135−mud=6.68×1034(S+551)−9.6and NTi−mud=5.74×1032(S+973)−8.3. Scanning electron microscope analysis results show that the S135 steel drillpipe presents brittle fracture, while titanium alloy drillpipe presents mixed fracture of quasi-cleavage and dimple. Finally, a case study of actual horizontal well was carried out to evaluate the fatigue damage of two drillpipes; compared with conventional steel drillpipe, titanium alloy drillpipe can effectively resist fatigue damage in the drilling fluid environment. The fatigue test results and corrosion fatigue mechanism analysis in this paper can provide data and theoretical guidance for the study of drillpipe fatigue life.
Using RBF-based artificial neural network to optimization of betulinic acid ester enzymatic synthesis
Authors: Hosseinpour Alireza , Poorsargol Mahdiye 
Published: November 2022

Abstract
Modeling of reaction conditions in the enzymatic synthesis of betulinic acid ester with multi-layer perceptron (MLP) which is a class of feed forward artificial neural network (ANN) has been done. Error to test data depends on not only trained method but also number of neuron in hidden layer. Often, it is much more of error to training data. In this manuscript Radial Basis Function (RBF) has been utilized. It determines the number of neuron due to desired error. In appropriate ANN, error for training data and test data are close. Therefore RBF’s parameters are set by multi objective meta-heuristic algorithm, in a way that, mentioned purposes have been obtained. The results of this method will be compared with previous methods.
Expression and Function of Modulator of Apoptosis (MOAP-1) in Blood Cancers
Authors: Law Jennifer , Svystun Orysya , Flood Kayla , Fahlman Richard , Kerek Evan , Narendran Aru , Baksh Shairaz 
Published: November 2022

Abstract
Objective: The function of the Ras association domain family 1 (RASSF1)/modulator of apoptosis
1 (MOAP-1) molecular tumor suppressor pathway is often perturbed in many solid and blood
cancers by epigenetic loss of RASSF1A via promoter specific methylation. However, a detailed
analysis of expression and stability of MOAP-1 as well as effect on cellular proliferation and cell
death in blood cancers has not been explored.
Materials and Methods: Expression of MOAP-1 RASSF1A was performed by immunoblotting
analysis, MOAP-1 effect on biology determined by cell proliferation, cell death and
tumorigenicity assays. Lastly, proteomic analysis in MOAP-1 in form 1 and 2 expressing cells
reveal new interacting partners to MOAP-1.
Results: The expression of MOAP-1 appears to be quite varied and exists as two forms, a p39 and
p46 form in blood cancers. The higher MOAP-1 p46 form was mainly observed in acute myeloid
leukemia (AML) and some acute lymphocytic leukemia (ALL) patients and cell lines.
Furthermore, MOAP-1 p46 form can be reduced to the p39 form upon calf intestinal or lambda
phosphatase treatment, suggesting post-translational phosphorylation likely produces the slower
migrating form. Blood cancer cell lines containing the p46 form of MOAP-1 appears to be more
resistant to cell death signals and have increased growth. In addition, we document in vivo
protection from tumorigenesis of cells containing MOAP-1 following tail vein injection of cancer
cells. Lastly, proteomic analysis revealed several interesting components of the MOAP-1
interactome in blood cancer cells that we validated.
Conclusions: MOAP-1 is a bona fide tumor suppressor in blood cancers with functions beyond
apoptosis.
High-throughput sequencing reveals that microRNA from exosomes as potential pathogenetic factors and biomarkers of moyamoya disease
Authors: Huang Da , Qi Hui , Yang Hongchun , chen Meng 
Published: November 2022

Abstract
Background: As a progressive cerebrovascular disease, moyamoya disease is a common cause of stroke in children and adults; however, early biomarkers and the pathogenesis of moyamoya disease remain poorly understood.
Objective: We aimed todiagnose moyamoya disease by identifying noninvasive rapid liquid diagnostic biomarkers using plasma exosomal microRNAs (miRNAs).
Methods and Material: For the first time, frozen plasma samples from moyamoya disease patients, next-generation high-throughput sequencing technologies, real-time quantitative PCR, gene ontology analysis and Kyoto Encyclopaedia of Genes and Genomes pathway analysis analyses of exosomal miRNA-related target gene functions were used to identify plasma exosomal miRNAs as potential biomarkers of moyamoya disease. The area under the curve of the receiver operating characteristic (ROC) curve was used to evaluate the sensitivity and specificity of biomarkers for predicting events.
Results: The target genes of the different expression miRNA showed that they were mainly enriched in axon guidance, regulation of the actin cytoskeleton and the MAPK signalling pathway. Ten miRNAs (miR-1306-5p, miR-196b-5p, miR-19a-3p, miR-22-3p, miR-320b, miR-34a-5p, miR-485-3p, miR-489-3p, miR-501-3p, and miR-487-3p) were found to be associated with the most sensitive and speciﬁc pathways for predicting moyamoya disease.
Conclusions: Plasma exosomal miRNAs could be used to construct an accurate predictive model for improving moyamoya disease detection.
An increase in peripheral blood CD86-positive plasmacytoid dendritic cells is associated with immune-related adverse events after immune checkpoint inhibitor therapy in patients with non-small cell lung cancer
Authors: Karayama Masato , Mizoguchi Yukihiro , Inoue Yusuke , Hozumi Hironao , Suzuki Yuzo , Furuhashi Kazuki , Fujisawa Tomoyuki , Enomoto Noriyuki , Nakamura Yutaro , Inui Naoki , Suda Takafumi , Kitano Shigehisa , Aoki Kazunori , Yamada Yasuhide 
Published: November 2022

Abstract
Background: The occurrence of immune-related adverse events (irAEs) after immune checkpoint inhibitors (ICIs) is unpredictable. Peripheral blood mononuclear cell (PBMC) profiles, representing host immune status, have potential for predicting irAEs.
Methods: PBMC subsets were measured using multicolor flow cytometry before and at weeks 2 and 8 after the initiation of ICIs in patients with non-small cell lung cancer.
Results: Sixteen evaluable patients were eligible for the analysis. The following irAEs occurred in 6 (37.5%) patients: diarrhea (n = 2), diarrhea and rash (n = 1), pneumonitis (n = 1), pituitary dysfunction (n = 1), and cholangitis (n = 1). Patients with irAEs demonstrated higher levels of CD86+plasmacytoid dendritic cells (pDCs) at baseline and weeks 2 and 8 after the ICIs than patients without irAEs (p = 0.005, 0.038, and 0.050, respectively). In patients with irAEs, the levels of CD86+pDCs decreased at weeks 2 and 8 compared with baseline (p =0 .034 and 0.025, respectively) but did not change in patients without irAEs. Other PBMC subsets had no significant associations with irAEs. Higher levels of natural killer (NK) cells were significantly associated with overall objective response (p = 0.024).
Conclusions: Higher levels of CD86+pDCs at baseline and the reduction at 2 and 8 weeks after the ICIs were associated with the occurrence of irAEs. Higher levels of NK cells were associated with therapeutic efficacy. Measurements of PBMCs may be useful for predicting the efficacy and safety of ICIs.
Implementation of an Antimicrobial Stewardship Program in the Vascular Surgery Ward of a university tertiary care hospital in Pavia, Northern Italy
Authors: Vecchia Marco , Colaneri Marta , Sacchi Paolo , Marvulli Lea Nadia , Salvaderi Andrea , Lanza Jessica , Boschini Stefano , Ragni Franco , Marone Piero , Cutti Sara , Muzzi Alba , Marena Carlo , Calvi Monica , Scudeller Luigia , Marone Enrico Maria , Bruno Raffaele 
Published: November 2022

Abstract
Purpose.
The commitment of multidisciplinary teams in antimicrobial stewardship programs (ASPs) is often inadequately considered, especially in surgical wards. We wanted to evaluate clinical, microbiological, and pharmacological outcomes before and after the implementation of an ASP in the Vascular Surgery ward of Fondazione IRCCS Policlinico San Matteo, a tertiary care hospital in Pavia, Italy.
Methods.
This was a quasi-experimental quality-improvement study. The antimicrobial stewardship activity was conducted twice a week for 12 months and consisted of both prospective audit and feedback of all the ongoing antimicrobial prescriptions by the infectious diseases’ consultants and educational meetings for the healthcare workers of the Vascular Surgery ward. For comparison between the study periods, Student t test (Mann-Whitney test for skewed distributions) was used for quantitative variables (ANOVA or Kruskall-Wallis for > 2 groups respectively), and Pearson’s chi-squared test (Fisher exact test where appropriate) for categorical variables. 2-tailed tests were used. P-value significance cut-off was 0.05.
Results.
During the 12-month intervention period, among a total number of 689 patients, 186 prescriptions were revised, mostly leading to de-escalating an ongoing antimicrobial therapy (39, 20.97%). A statistically significant reduction in isolates of carbapenem-resistant Pseudomonas aeruginosa (p-value 0.003) and the absence of Clostridioides difficile infections were reported. No statistically significant changes were observed in terms of length of stay and all-cause in-hospital mortality. A significant decrease in the administration of carbapenems (p-value 0.01), daptomycin (p-value < 0.01) and linezolid (p-value 0.43) was registered. A significant reduction in antimicrobial costs was also observed.
Conclusions.
The implementation of a 12-month ASP brought significant clinical and economic results, highlighting the benefits of a multidisciplinary teamwork.