bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation
Authors: Luo Aoran , Lan Xiaoxiao , Qiu Qiongzi , Zhou Qing , Li Jia , Wu Mengting , Liu Pengyuan , Zhang Honghe , Lu Bingjian , Lu Yan , Lu Weiguo 
Published: November 2022

AbstractLong non-coding RNAs (lncRNAs) play key roles in cancer development and progression. However, the biological function and clinical significance of most lncRNAs in cervical cancer remain elusive. In this study, we explore the function and mechanism of lncRNA surfactant associated 1 (SFTA1P) in cervical cancer. We firstly identified SFTA1P by analyzing the RNA sequencing data of cervical cancer from our previous study and from The Cancer Genome Atlas (TCGA). We then verified SFTA1P expression by qRT-PCR. The cell proliferation and migration capacity of SFTA1P was assessed by using CCK-8, colony formation, transwell and wound healing assays. RNA pull-down, RNA immunoprecipitation (RIP), RNA stability and western blot assays were used to reveal potential mechanisms. Athymic nude mice were used to evaluate tumorigenicity and metastasis in vivo. SFTA1P is upregulated in cervical tumor tissues and its high expression is associated with poor prognosis. Biologically, knockdown of SFTA1P inhibited the proliferation, migration, and invasion of cervical cancer cells in vitro, as well as tumorigenesis and metastasis in vivo. Mechanistically, SFTA1P was shown to interact with polypyrimidine tract binding protein 1 (PTBP1) to regulate the stability of tropomyosin 4 (TPM4) mRNA, thereby resulting in malignant cell phenotypes. TPM4 knockdown could attenuate the suppression of cell progression induced by either SFTA1P or PTBP1 knockdown. Our findings demonstrate that SFTA1P can promote tumor progression by mediating the degradation of TPM4 mRNA through its interaction with PTBP1 protein. This provides a potential therapeutic strategy to target the SFTA1P-PTBP1-TPM4 axis in cervical cancer.
Unlocking the human inner ear for therapeutic intervention
Authors: Li Hao , Agrawal Sumit , Rohani Seyed Alireza , Zhu Ning , Cacciabue Daniela I. , Rivolta Marcelo N. , Hartley Douglas E. H. , Jiang Dan , Ladak Hanif M. , O’Donoghue Gerard M. , Rask-Andersen Helge 
Published: November 2022

AbstractThe human inner ear contains minute three-dimensional neurosensory structures that are deeply embedded within the skull base, rendering them relatively inaccessible to regenerative therapies for hearing loss. Here we provide a detailed characterisation of the functional architecture of the space that hosts the cell bodies of the auditory nerve to make them safely accessible for the first time for therapeutic intervention. We used synchrotron phase-contrast imaging which offers the required microscopic soft-tissue contrast definition while simultaneously displaying precise bony anatomic detail. Using volume-rendering software we constructed highly accurate 3-dimensional representations of the inner ear. The cell bodies are arranged in a bony helical canal that spirals from the base of the cochlea to its apex; the canal volume is 1.6 μL but with a diffusion potential of 15 μL. Modelling data from 10 temporal bones enabled definition of a safe trajectory for therapeutic access while preserving the cochlea’s internal architecture. We validated the approach through surgical simulation, anatomical dissection and micro-radiographic analysis. These findings will facilitate future clinical trials of novel therapeutic interventions to restore hearing.
Additive manufacturing of LiNi1/3Mn1/3Co1/3O2 battery electrode material via vat photopolymerization precursor approach
Authors: Martinez Ana C. , Maurel Alexis , Aranzola Ana P. , Grugeon Sylvie , Panier Stéphane , Dupont Loic , Hernandez-Viezcas Jose A. , Mummareddy Bhargavi , Armstrong Beth L. , Cortes Pedro , Sreenivasan Sreeprasad T. , MacDonald Eric 
Published: November 2022

AbstractAdditive manufacturing, also called 3D printing, has the potential to enable the development of flexible, wearable and customizable batteries of any shape, maximizing energy storage while also reducing dead-weight and volume. In this work, for the first time, three-dimensional complex electrode structures of high-energy density LiNi1/3Mn1/3Co1/3O2(NMC 111) material are developed by means of a vat photopolymerization (VPP) process combined with an innovative precursor approach. This innovative approach involves the solubilization of metal precursor salts into a UV-photopolymerizable resin, so that detrimental light scattering and increased viscosity are minimized, followed by the in-situ synthesis of NMC 111 during thermal post-processing of the printed item. The absence of solid particles within the initial resin allows the production of smaller printed features that are crucial for 3D battery design. The formulation of the UV-photopolymerizable composite resin and 3D printing of complex structures, followed by an optimization of the thermal post-processing yielding NMC 111 is thoroughly described in this study. Based on these results, this work addresses one of the key aspects for 3D printed batteries via a precursor approach: the need for a compromise between electrochemical and mechanical performance in order to obtain fully functional 3D printed electrodes. In addition, it discusses the gaps that limit the multi-material 3D printing of batteries via the VPP process.
Impact of a single water molecule on the atmospheric oxidation of thiophene by hydroperoxyl radical
Authors: Douroudgari Hamed , Sharifi Maryam Seyed , Vahedpour Morteza 
Published: November 2022

AbstractWater as an important assistant can alter the reactivity of atmospheric species. This project is designed to investigate the impact of a single water molecule on the atmospheric reactions of aromatic compounds that have not been attended to comprehensively. In the first part, the atmospheric oxidation mechanisms of thiophene initiated by hydroperoxyl radical through a multiwell-multichannel potential energy surface were studied to have useful information about the chemistry of the considered reaction. It was verified that for the thiophene plus HO2 reaction, the addition mechanism is dominant the same as other aromatic compounds. Due to the importance of the subject and the presence of water molecules in the atmosphere with a high concentration that we know as relative humidity, and also the lack of insight into the influence of water on the reactions of aromatic compounds with active atmospheric species, herein, the effect of a single water molecule on the addition pathways of the title reaction is evaluated. In another word, this research explores how water can change the occurrence of reactions of aromatic compounds in the atmosphere. For this, the presence of one water molecule is simulated by higher-level calculations (BD(T) method) through the main interactions with the stationary points of the most probable pathways. The results show that the mechanism of the reaction with water is more complicated than the bare reaction due to the formation of the ring-like structures. Also, water molecule decreases the relative energies of all addition pathways. Moreover, atoms in molecule theory (AIM) along with the kinetic study by the transition state (TST) and the Rice–Ramsperger–Kassel–Marcus (RRKM) theories demonstrate that the overall interactions of a path determine how the rate of that path changes. In this regard, our results establish that the interactions of water with HO2 (thiophene) in the initial complex 1WHA (1WTA or 1WTB) are stronger (weaker) than the sum of its interactions in transition states. Also, for the water-assisted pathways, the ratio of the partition function of the transition state to the partition functions of the reactants is similar to the respective bare reaction. Therefore, the reaction rates of the bare pathways are more than the water-assisted paths that include the 1WHA complex and are less than the paths that involve the 1WTA and 1WTB complexes.
Contrastive language and vision learning of general fashion concepts
Authors: Chia Patrick John , Attanasio Giuseppe , Bianchi Federico , Terragni Silvia , Magalhães Ana Rita , Goncalves Diogo , Greco Ciro , Tagliabue Jacopo 
Published: November 2022

AbstractThe steady rise of online shopping goes hand in hand with the development of increasingly complex ML and NLP models. While most use cases are cast as specialized supervised learning problems, we argue that practitioners would greatly benefit from general and transferable representations of products. Inthiswork, we build on recent developments in contrastive learning to trainFashionCLIP, aCLIP-like model adapted for the fashion industry. We demonstrate the effectiveness of the representations learned byFashionCLIPwith extensive tests across a variety of tasks, datasets and generalization probes. We argue that adaptations of large pre-trained models such as CLIP offer new perspectives in terms of scalability and sustainability for certain types of players in the industry. Finally, we detail the costs and environmental impact of training, and release the model weights and code as open source contribution to the community.
Complications of patients with bone tumors treated with carbon-fiber plates: an international multicenter study
Authors:   Carbon-Fiber International Collaboration Initiative Research Group, Rijs Zeger , Weekhout Amber , Lozano-Calderon Santiago A. , Groot Olivier Q. , Berner Emily , Merchan Nelson , Yeung Caleb M. , Oliveira Vsania , Bianchi Giuseppe , Staals Eric , Lana Debora , Donati Davide , Segal Ortal , Marone Stefano , Piana Raimondo , De Meo Simone , Pellegrino Pietro , Ratto Nicola , Zoccali Carmine , Scorianz Maurizio , Tomai Cecilia , Scoccianti Guido , Campanacci Domenico Andrea , Andreani Lorenzo , de Franco Silvia , Boffano Michele , Cosker Thomas , Sethurajah Varunprasanth , Pensado Manuel Peleteiro , Ruiz Irene Barrientos , Moreno Esperanza Holgado , Ortiz-Cruz Eduardo Jose , van de Sande Michiel 
Published: November 2022

AbstractCarbon-fiber (CF) plates are a promising alternative to metal plates. However, reported experience in orthopaedic oncology remains limited. The aim of this study was to identify complications of patients with bone tumors treated with CF plates. Between February 2015 and May 2021, 13 centers retrospectively registered patients with bone tumors that were reconstructed using CF plates. Complications were identified, and timing and etiology of complications were noted. Similar complications were tabulated and classified based on mechanical, non-mechanical and paediatric complications. Mechanical complications included: (1) aseptic loosening or graft-host non-union, and (2) structural complications. Non-mechanical complications included: (3) soft tissue complications, (4) infection and (5) tumor progression. Specific paediatric complications included (6) growth arrest resulting in longitudinal or angular deformity. Ninety-six patients were included with a median follow-up time of 35 months. In total, 22 (23%) patients had complications. Mechanical complications included: 1 (1%) aseptic loosening, 2 (2%) non-unions, and 7 (7%) structural complications. Non-mechanical complications included 1 (1%) soft tissue complication, 4 (4%) infections and 5 (5%) tumor progressions. Paediatric complications occurred in 2 (2%) patients. This study suggests CF plates are safe to use in demanding reconstructions after bone tumor resections, presenting a seemingly low complication profile.
Graph-generative neural network for EEG-based epileptic seizure detection via discovery of dynamic brain functional connectivity
Authors: Li Zhengdao , Hwang Kai , Li Keqin , Wu Jie , Ji Tongkai 
Published: November 2022

AbstractDynamic complexity in brain functional connectivity has hindered the effective use of signal processing or machine learning methods to diagnose neurological disorders such as epilepsy. This paper proposed a new graph-generative neural network (GGN) model for the dynamic discovery of brain functional connectivity via deep analysis of scalp electroencephalogram (EEG) signals recorded from various regions of a patient’s scalp. Brain functional connectivity graphs are generated for the extraction of spatial–temporal resolution of various onset epilepsy seizure patterns. Our supervised GGN model was substantiated by seizure detection and classification experiments. We train the GGN model using a clinically proven dataset of over 3047 epileptic seizure cases. The GGN model achieved a 91% accuracy in classifying seven types of epileptic seizure attacks, which outperformed the 65%, 74%, and 82% accuracy in using the convolutional neural network (CNN), graph neural networks (GNN), and transformer models, respectively. We present the GGN model architecture and operational steps to assist neuroscientists or brain specialists in using dynamic functional connectivity information to detect neurological disorders. Furthermore, we suggest to merge our spatial–temporal graph generator design in upgrading the conventional CNN and GNN models with dynamic convolutional kernels for accuracy enhancement.
A prospective, controlled study on the utility of rotational thromboelastometry in surgery for acute type A aortic dissection
Authors: Larsson Mårten , Zindovic Igor , Sjögren Johan , Svensson Peter J. , Strandberg Karin , Nozohoor Shahab 
Published: November 2022

AbstractTo evaluate the hemostatic system with ROTEM in patients undergoing surgery for acute type aortic dissection (ATAAD) using elective aortic procedures as controls. This was a prospective, controlled, observational study. The study was performed at a tertiary referral center and university hospital. Twenty-three patients with ATAAD were compared to 20 control patients undergoing elective surgery of the ascending aorta or the aortic root. ROTEM (INTEM, EXTEM, HEPTEM and FIBTEM) was tested at 6 points in time before, during and after surgery for ATAAD or elective aortic surgery. The ATAAD group had an activated coagulation coming into the surgical theatre. The two groups showed activation of both major coagulation pathways during surgery, but the ATAAD group consistently had larger deficiencies. Reversal of the coagulopathy was successful, although none of the groups reached elective baseline until postoperative day 1. ROTEM did not detect low levels of clotting factors at heparin reversal nor low levels of platelets. This study demonstrated that ATAAD is associated with a coagulopathic state. Surgery causes additional damage to the hemostatic system in ATAAD patients as well as in patients undergoing elective surgery of the ascending aorta or the aortic root. ROTEM does not adequately catch the full coagulopathy in ATAAD. A transfusion protocol in ATAAD should be specifically created to target this complex coagulopathic state and ROTEM does not negate the need for routine laboratory tests.
The Feasibility of Home-Based Treatment Using Vibratory Stimulation in Chronic Severe Dysphagia
Authors: Kamarunas Erin , Mulheren Rachel , Wong Seng Mun , Griffin Lindsay , Ludlow Christy L. 
Published: November 2022

Purpose:
Previously, externally placed vibratory laryngeal stimulation increased rates of swallowing in persons with and without dysphagia. This study examined the feasibility of using a vibratory device on the skin over the thyroid cartilage for home-based swallowing rehabilitation in long-standing dysphagia.

Method:
Only participants with long-standing dysphagia (> 6 months) following cerebrovascular accident or head/neck cancer who had not previously benefited from dysphagia therapy participated. The device had two modes used daily for 90 days. In automatic mode, participants wore the device when awake, which vibrated for 4–8 s every 5 min to trigger a volitional swallow. In manual mode, participants practiced by activating vibration while swallowing rapidly. Study-related adverse events, such as pneumonia, and device-recorded adherence were tracked. Swallowing function on a modified barium swallow study was assessed at baseline and after 3 months of device use. Outcome measures included the Dysphagia Outcome and Severity Scale (DOSS), Penetration–Aspiration Scale (PAS), and swallowing timing measures. Participants' perceptions of the vibratory device and training were obtained.

Results:
The intent to treat analysis showed seven of 11 participants completed the study, all with severe chronic dysphagia. Of those seven participants completing the study, two developed respiratory complications (possibly due to pneumonia) that cleared after antibiotic intervention. For prescribed practice trials, adherence was 80% or greater in four of seven participants (57%) whereas prescribed automatic stimulations were met in only two of seven participants (29%). Three participants (43%) had a modest benefit on DOSS. The time to vestibule closure after the bolus passed the ramus was reduced in five participants (71%) on the modified barium swallow study.

Conclusion:
Overall, the results have indicated that intensive home-based practice with stimulation may provide limited functional benefits in severe chronic dysphagia.

Supplemental Material:

https://doi.org/10.23641/asha.21498591
Evaluating Different Scoring Systems for a Picture Description Task Among Preschool Children Who Speak African American English
Authors: Hendricks Alison Eisel , Jerard Jillian , Guo Ling-Yu 
Published: November 2022

Purpose:
Measures of grammatical accuracy are effective measures of children's language skills. However, many measures, such as percent grammatical utterances, were developed for children who speak General American English (GAE) and, therefore, may not be appropriate for students who speak other dialects. This study examines different scoring systems for a picture description task to explore the impact of different systems for children who speak African American English (AAE).

Method:
Eighteen preschool-age children who speak AAE completed a play-based language sample and a picture description task. The Index of Productive Syntax (IPSyn) was calculated for the play-based language samples and used as the reference measure. The picture description task was scored using four scoring systems: an expansive AAE scoring system, a GAE scoring system, and two strategic scoring systems. Scores were compared for each scoring system, and correlations between IPSyn scores and picture description scores were conducted.

Results:
Scores on the picture description task were highest in the expansive AAE scoring system, followed by scores in the strategic scoring systems, all of which were higher than scores in the GAE scoring system. There was a significant correlation between IPSyn scores and picture description scores when using the GAE scoring system and the strategic scoring systems, but not when using the expansive AAE scoring system.

Conclusions:
Different scoring systems affect AAE-speaking preschoolers' scores on measures of grammatical accuracy, and the use of an expansive AAE scoring system, based on lists of nonmainstream features, may diminish the ability to differentiate between children with different ability levels. Future research is needed to refine scoring systems and to explore the validity of different scoring systems for detecting differences between preschoolers who speak AAE, with and without developmental language disorder.

Supplemental Material:

https://doi.org/10.23641/asha.21498618
Student Clinicians' Views of Telepractice and In-Person Service Delivery
Authors: Page Christen Guffey , Hughes Charles , Woody Rachel 
Published: November 2022

Purpose:
The purpose of this study was to compare graduate student clinicians' self-reported perceptions of in-person versus telepractice service delivery based on preparation/training, treatment process, client and clinician engagement, data collection, and client progress.

Method:
This study used mixed methodology to answer three research questions: (a) What are the differences between students clinicians' perceptions pre– and post–in-person and telepractice service delivery, (b) What are the differences between student clinicians' views of in-person and telepractice service delivery, and (c) How do changes in the pre- and post-surveys represent the student clinicians' views of in-person versus telepractice service delivery? Graduate students completed pre- and post-surveys and participated in focus groups following 16 weeks of telepractice or in-person service delivery.

Results:
Overall, findings revealed more similarities than differences between telepractice and in-person service delivery based on students' self-report before and after treatment. Similarities included preparation methods, use of evidence-based practice, amount of family involvement, and client progress. Differences included amount of time to prepare for the session, establishing rapport, and collecting data. In the end, participants' self-efficacy and implementation readiness increased for both service delivery models.

Conclusion:
Findings from this study provide a foundation for graduate training by relating telepractice to in-person service delivery models.

Supplemental Material:

https://doi.org/10.23641/asha.21498636
What’s the Evidence? A Commentary on FEES Research
Authors: Pisegna Jessica M. 
Published: November 2022

Purpose:
Fiberoptic endoscopic evaluation of swallowing (FEES) is a well-respected swallowing assessment, harking back to 1988 when it was first published by Susan Langmore as a procedure. Since then, its methodology has evolved to afford clinicians, researchers, and patients a sensitive, specific, and predictive exam. A myriad research has investigated FEES technique and its outcomes, rendering it an effective and efficient procedure for swallowing assessment and therapy. This commentary will outline evidence for FEES to support evidence-based practice. What is the evidence for speech tasks? Secretion scales? What is the predictive nature of aspiration as seen on FEES? This comprehensive review will outline the science bolstering the use and confidence in FEES.

Conclusions:
This commentary reviews studies that have proposed normative data collected via FEES for decision making, specifically when assessing pharyngeal and laryngeal anatomy, bolus spillage, and the white out period. Evidence for FEES sensitivity and predictive aspects are reviewed in relationship to speech tasks, secretions, aspiration and penetration–aspiration scale scores, and pharyngeal residue scales. The acute care advantage of FEES is defined in its use on postextubation populations, assessment of dysphagia in COVID-19 positive patients, and safe evaluation during ice chip administration with acutely ill patients. Finally, inference making on FEES is discussed in regard to epiglottic retroflexion and depth of aspiration.
When it comes to assessing pharyngeal dysphagia, the true strengths of FEES are rooted in evidence. It has been shown to be sensitive, predictive, and practical and will likely continue to have stronger support as research continues to enrich its potential.

Supplemental Material:

https://doi.org/10.23641/asha.21498699