bluuebunny/crossref_metadata_2025_split huggingface dataset:
Commentary on Cochrane review: “Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder”
Authors: Borentain Stephane , Desai Pooja , Fu Dong-Jing , Nancy Chen Li , Lane Rosanne , Mathews Maju , Canuso Carla M 
Published: October 2022

Background: Cochrane recently published a review of esketamine and other glutamate receptor modulators in depression. Aim: To address the limitations of the review, analyses of esketamine data were conducted to provide additional perspective to the reviewers’ interpretation of their findings. Methods: Response rate, remission rate, and change from baseline in Montgomery-Åsberg Depression Rating Scale (MADRS) total score were determined using data from all esketamine phase 2/3 registration studies of treatment-resistant depression (TRD) and, separately, all esketamine phase 2/3 registration studies of major depressive disorder (MDD) and active suicidal ideation with intent. Outcomes were assessed at all timepoints (i.e., 24 h, 72 h (MDD with active suicidal intent only), and 1, 2, and 4 weeks). Enrollment criteria of the TRD studies were different than those of the studies of MDD and active suicidal ideation with intent, resulting in differences in patients’ clinical characteristics and depression severity between the cohorts. Thus, we did not compare results between these cohorts (as was done in the Cochrane review). Results/outcomes: In the combined TRD studies, a statistically significant between-group difference favored esketamine plus antidepressant over antidepressant plus placebo at 24 h (based on response, remission, and change in MADRS score), 1 week (change in MADRS score), 2 weeks (response and change in MADRS score), and 4 weeks (response, remission, and change in MADRS score). In the combined studies of MDD and active suicidal ideation with intent, the between-group difference was statistically different, favoring esketamine plus standard-of-care over placebo plus standard-of-care, at 24 h (response, remission, and change in MADRS score), 72 h and 1 week (change in MADRS score), 2 weeks (response), and 4 weeks (response, remission, and change in MADRS score). For both study types, the between-group difference in outcomes was not statistically significant at the other timepoints. Conclusions/interpretation: Esketamine improves response, remission, and depressive symptoms as early as 24 h post-first dose among patients with TRD and among patients with MDD and active suicidal ideation with intent.
Performance evaluation of melamine derivatives as flame retardant additive in chicken feather containing thermoplastic polyurethane biocomposites
Authors: Mutlu Aysenur , Tayfun Umit , Dogan Mehmet 
Published: October 2022

The objective of this research is to examine the potential use of melamine derivatives namely melamine cyanurate (MC), melamine phosphate (MP), and melamine polyphosphate (MPP) as flame retardant additives in chicken feather (CF) containing thermoplastic polyurethane (TPU). The performances of the composites are evaluated using limiting oxygen index (LOI), vertical UL-94 (UL-94 V), and mass loss calorimeter (MLC) tests. The V0 rating is achieved with the addition of 10 wt% MC, 20 wt% MP, and MPP. The performances of the additives are ranked in the ascending order of MC, MP, and MPP in LOI test. MP and MPP show distinct better performance than MC in the condensed phase. However, the gas phase action of MC is much better. than MP, and MPP. The lowest pHRR (103 Kw/m2), THE (39 MJ/m2), and THE/TML ratio (1.4 MJ/m2g) are observed with the use of 20 wt% MPP, MP, and MC, respectively.
Montreal cognitive assessment as a screening instrument for cognitive impairment in systemic lupus erythematosus patients without overt neuropsychiatric manifestations
Authors: Lim Xin Rong , Chew Pamela Oi Khuan , Lim Gek Hsiang , Low Yung Ling , Lim June Wei Ping , Ong Huey Ni , Law Weng Giap , Tan Justina Wei Lynn , Thong Bernard YH , Chia Faith Li-Ann , Lian Tsui Yee , Chan Grace Yin Lai , Chan Madelynn Tsu-Li , Koh Ee Tzun , Kong Kok Ooi , Howe Hwee Siew 
Published: October 2022

Objectives The Montreal Cognitive Assessment (MoCA) is an increasingly used screening tool for cognitive impairment. The aim of this study was to examine how MoCA performed in identifying cognitive impairment (CI) domains in SLE patients compared with formal standardized neuropsychological testing (NPT). Factors related to SLE disease, immunologic and psychological state associated with CI were also explored. Methods This cross-sectional study recruited 50 SLE patients without overt neuropsychiatric manifestations from April 2017 to May 2018. The patients were evaluated with MoCA, formal NPT and the Depression, Anxiety, and Stress Scales (DASS) 42-item self-report questionnaire. Values of sensitivity and specificity were computed for different cut-offs of MoCA within each cognitive domain of NPT and descriptive analysis was used to identify the factors affecting cognitive function. Results The median score for MoCA was 27.5 (range 22–30). Using a MoCA cutoff of <26, 18 (36%) were identified to have CI using NPT compared to 8 (16%) using MoCA. The most frequently affected cognitive domain was executive functioning with 15 affected patients. Sensitivities and specificities of the MoCA range from 50% to 100% and 5.7% to 16.7%, respectively, across cognitive domains. A lower MoCA cutoff of <25 improve sensitivity of identifying impairment in executive functioning from 60% to 80%. In univariate analysis, DASS scores, disease activity, presence of antiphospholipid antibodies, presence of concurrent autoimmune disease, current, and cumulative corticosteroid therapy did not predict cognitive performance. Conclusion MoCA may be a useful screening tool to identify the most frequently affected cognitive domain which is executive functioning using a lower cutoff of <25 in SLE patients without overt neuropsychiatric manifestations.
Feminist Social Vision: Seeing Through the Lens of Marginalized Perceivers
Authors: Oswald Flora , Adams Reginald B. 
Published: October 2022

Social vision research, which examines, in part, how humans visually perceive social stimuli, is well-positioned to improve understandings of social inequality. However, social vision research has rarely prioritized the perspectives of marginalized group members. We offer a theoretical argument for diversifying understandings of social perceptual processes by centering marginalized perspectives. We examine (a) how social vision researchers frame their research questions and who these framings prioritize and (b) how perceptual processes (person perception; people perception; perception of social objects) are linked to group membership and thus comprehensively understanding these processes necessitates attention to marginalized perceivers. We discuss how social vision research translates into theoretical advances and to action for reducing negative intergroup consequences (e.g., prejudice). The purpose of this article is to delineate how prioritizing marginalized perspectives in social vision research could develop novel questions, bridge theoretical gaps, and elevate social vision’s translational impact to improve outcomes for marginalized groups. Public Abstract Social vision research is a subfield of psychology and vision science which examines how people visually perceive social stimuli and what the downstream consequences of these perceptions are. Social vision work includes, for example, examination of how White people visually perceive racial minorities and how these perceptions lead to social categorizations of racial minorities as outgroups, and therefore contribute to behaviors such as stereotyping and prejudice. Social vision research has rarely prioritized the perspectives of marginalized group members. It therefore cannot fully explain the contributions of perception to intergroup relations, which are necessarily bidirectional. We offer a theoretical argument for diversifying understandings of social perceptual processes by centering marginalized perspectives to understand how people with marginalized identities see their social worlds. We believe that prioritizing these marginalized perspectives has the potential to contribute to the development of a psychological science with heightened capacity to improve the well-being of people with marginalized identities.
Detecting dodgy behaviour: The role of autism, autistic traits and theory of mind
Authors: Brewer Neil , Lucas Carmen A , Lim Alliyza , Young Robyn L 
Published: October 2022

We examined whether theory of mind difficulties often considered to characterise autistic individuals impair their ability to detect the presence of dodgy or suspicious behaviour in interactions, thereby rendering them especially vulnerable to becoming involved in criminal activity or being victimised. Using a signal detection theory approach, we compared autistic ( N = 72; Verbal Comprehension Index = 88–122, M = 106.6) and non-autistic ( N = 70; Verbal Comprehension Index = 86–120, M = 104.4) adults’ ability to detect dodgy or suspicious behaviour across a broad array of scenarios ( N = 136). Although theory of mind performance was poorer for the autistic group, frequentist and Bayesian analyses indicated there were no group differences in either the standard measures of discrimination performance obtainable using a signal detection theory approach or in terms of a bias towards reporting dodgy behaviour. Furthermore, there was no indication of a relationship between dodginess detection and autistic traits. However, regardless of group membership, theory of mind difficulties were associated with poorer discrimination of dodgy behaviour, highlighting an individual difference variable that may increase the vulnerability of both autistic and non-autistic individuals to involvement in some form of criminal activity or to becoming a victim of crime. Lay abstract Difficulties in reading others’ minds make it difficult to anticipate their future behaviour. It has often been argued that such difficulties contribute to autistic individuals becoming enmeshed in criminal activity. However, supportive scientific evidence is virtually non-existent. We compared the ability of groups of autistic and non-autistic adults of similar intellectual ability to detect dodgy or suspicious behaviour across a wide range of scenarios. Although the autistic group performed more poorly than the non-autistic group on an established measure of mindreading, there were no group differences in the ability to detect dodginess. Nor did we find any evidence that detecting dodgy behaviour was associated with the degree of autistic traits reported by individual participants. However, when we combined the two groups, difficulty reading the minds of others was indeed associated with poorer detection of dodginess, thus highlighting a characteristic of individuals that may well increase the likelihood of becoming involved in crime or exploited for autistic and non-autistic individuals alike.
Health-related quality of life and its predictors among people living with epilepsy at Dessie Referral Hospital, Amhara, Ethiopia: A cross-sectional study
Authors: Stotaw Alebachew Sisay , Kumar Prem , Beyene Dessale Abate , Tadesse Tamrat Assefa , Abiye Alfoalem Araba 
Published: October 2022

Objectives: Health-related quality of life of people living with epilepsy is significantly impaired. The disease causes a significant psychological and social impact on daily living conditions and usually has lifelong consequences for the patient and family. Therefore, this study aimed to investigate the health-related quality of life of people living with epilepsy and its predictors in Dessie Referral Hospital, Dessie, Ethiopia. Methods: A facility-based cross-sectional study was conducted from April to June 2020. Systematic random sampling was used to recruit a total of 385 study participants. Written informed consent was obtained for each participant, and data were collected using World Health Organization Quality of Life Brief Version and Hospital Anxiety and Depression Scale questionnaires. Descriptive statistics were used to summarize the data, while multivariate logistic regression analyses were used to examine factors affecting the quality of life. P value ⩽ 0.05 was considered statistically significant. Results: About 95.80% of the study participants had a generalized seizure, and 64.30% were on two antiepileptic drugs. Of the total, 12.20% and 37.00% suffered from depression and anxiety, respectively, based on the Hospital Anxiety and Depression Scale score. The mean total health-related quality of life score was 51.98 (standard deviation: ± 10.08; 95% confidence interval: 41.90–62.06) out of 100. Age, education level, marital status, occupation, residence, current comorbidity, family support, and recreational activities were associated with good health-related quality of life ( p ⩽ 0.05) Conclusion: The average overall quality of life of people living with epilepsy in the Dessie Referral Hospital was low. Therefore, concerted efforts must be made to improve the quality of life of patients over the healthcare services provided.
Giant splenic myelolipoma in a cat with hyperthyroidism
Authors: Rolph Kerry E , Vidana Beatriz , Field Elinor 
Published: October 2022

Case summary A 15 shorthair cat presented after having fallen down the stairs. Examination by the referring veterinarian had demonstrated tachycardia and a large abdominal mass. The cat was referred for investigations. Blood tests demonstrated hyperthyroidism. A large, poorly vascularised abdominal mass was identified on ultrasonography. The mass was hyperechoic compared with the normal liver; however, the origin could not be determined. Fine-needle aspirate biopsies of the mass demonstrated extramedullary haematopoiesis. Surgical exploration revealed a 12 cm × 8 cm × 8 cm pale mass arising from the spleen. Histopathology determined this was a giant splenic myelolipoma. Relevance and novel information Splenic myelolipoma is rarely reported in the domestic cat, with only five cases documented within the literature, and none of these having described giant myelolipoma. Indeed, giant myelolipomas are rarely reported in the human literature and are most commonly adrenal in origin. The pathogenesis of these masses is unclear; there have been several incidences in people with endocrine disorders, and it has been hypothesised that their occurrence may be related to endocrine stimulation. Here we report the first case of giant myelolipoma in a hyperthyroid cat.
Level of implementation of district health information system 2 at public health facilities in Eastern Ethiopia
Authors: Mekebo Merkineh , Gobena Tesfaye , Hawulte Behailu , Tamiru Dawit , Debella Adera , Yadeta Elias , Eyeberu Addis 
Published: October 2022

Objective The major aim of this study was to assess the level of District health information system 2 (DHIS 2) implementation in the public health facilities (HFs) in Dire Dawa City Administration. Methods This study was employed both quantitative (cross-sectional) and qualitative (phenomenological) study designs. All public HFs found in Dire Dawa City Administration and health workers were participated in the study. Quantitative data were collected using a pre-tested, structured, self-administered questionnaire. The collected data were entered into Epi-Data and analyzed using STATA version 14 software. A descriptive summary was computed using proportion and frequencies. Qualitative data were collected from in-depth interview with key informants (KIs), and the results were then analyzed thematically. Results The overall implementation level of DHIS 2 was 80%, which shows good implementation. The main difficulties encountered in implementing DHIS 2 were a lack of power backup (64.3%), unreliable internet connectivity (43%), and a lack of training (34.6%). According to an in-depth interview with a 32-year-old professional, “…there is offline and online DHIS 2 software for data collection and reporting that is an opportunity for the health center, but there is a challenge of interruption of electricity lost unsaved data and hinder data to enter and view for making a decision….” Conclusion The level of DHIS 2 implementation in this study was good compared to other studies in Ethiopia. However, more than half of the HFs require infrastructure maintenance and support.
Preparedness to Respond to Family Violence: A Cross-Sectional Study Across Clinical Areas
Authors: Withiel T. D. , Sheridan S. , Rudd N. , Fisher C. A. 
Published: October 2022

Introduction Family violence (FV) is one of the most urgent health issues of our generation. While nurses play a vital role in identifying and supporting victim/survivors of violence, little is known about nursing readiness to respond across clinical areas. Objective This study aimed to compare and contrast the knowledge, confidence, clinical skills, and perceived barriers of nurses across three clinical areas of a tertiary trauma hospital in Melbourne, Australia, in responding to FV. Method A prospective, mixed methods design was used. The nursing staff at a large trauma hospital were approached to participate. Participants completed a brief online survey to quantify clinician-reported knowledge, clinical skills, and barriers to managing FV. Results Two hundred and forty-two nursing staff electronically completed a brief survey to capture self-reported confidence, knowledge, clinical skills, and barriers to working effectively in the area. The descriptive analysis reflected service-wide deficits in knowledge, confidence, and self-reported clinical skills, irrespective of the work area. Deficits were identified on a background of limited structured training for FV among this cohort. Significantly higher rates of FV confidence and knowledge were identified among emergency department nurses relative to acute and subacute clinical counterparts. Conclusion Nurse respondents overall reported low rates of confidence, knowledge, and clinical skills in responding to disclosures of FV. Findings reinforce the need for imbedded training programs to support frontline responses.
Including Information on Overdiagnosis in Shared Decision Making: A Review of Prostate Cancer Screening Decision Aids
Authors: Pathirana Thanya I. , Pickles Kristen , Riikonen Jarno M. , Tikkinen Kari A. O. , Bell Katy J. L. , Glasziou Paul 
Published: October 2022

Background. Overdiagnosis is an accepted harm of cancer screening, but studies of prostate cancer screening decision aids have not examined provision of information important in communicating the risk of overdiagnosis, including overdiagnosis frequency, competing mortality risk, and the high prevalence of indolent cancers in the population. Methods. We undertook a comprehensive review of all publicly available decision aids for prostate cancer screening, published in (or translated to) the English language, without date restrictions. We included all decision aids from a recent systematic review and screened excluded studies to identify further relevant decision aids. We used a Google search to identify further decision aids not published in peer reviewed medical literature. Two reviewers independently screened the decision aids and extracted information on communication of overdiagnosis. Disagreements were resolved through discussion or by consulting a third author. Results. Forty-one decision aids were included out of the 80 records identified through the search. Most decision aids ( n = 32, 79%) did not use the term overdiagnosis but included a description of it ( n = 38, 92%). Few ( n = 7, 17%) reported the frequency of overdiagnosis. Little more than half presented the benefits of prostate cancer screening before the harms ( n = 22, 54%) and only 16, (39%) presented information on competing risks of mortality. Only 2 ( n = 2, 5%) reported the prevalence of undiagnosed prostate cancer in the general population. Conclusion. Most patient decision aids for prostate cancer screening lacked important information on overdiagnosis. Specific guidance is needed on how to communicate the risks of overdiagnosis in decision aids, including appropriate content, terminology and graphical display. Highlights Most patient decision aids for prostate cancer screening lacks important information on overdiagnosis. Specific guidance is needed on how to communicate the risks of overdiagnosis.
Labor market tightness and individual wage growth: evidence from Germany
Authors: Brunow Stephan , Lösch Stefanie , Okhrin Ostap 
Published: October 2022

AbstractIt is often stated that certain occupations in Germany, because of “Demographic Change“, are dwindling, implying a labor shortage. We investigate the 10-year wage growth of young employees entering the labor market in different occupations. Our findings suggest that regional labor market tightness in occupational fields significantly explains wage growth. Individuals who start their careers in a tighter labor market enjoy higher wage growth than workers in more relaxed labor markets. We identify some occupational fields where the effect is especially strong, such as several engineering groups, IT occupations, technicians, and some commercial occupations. Interestingly, health-care occupations reveal a reverse relation.
Functional analysis revealed the involvement of ZmABCB15 in resistance to rice black-streaked dwarf virus infection
Authors: Yue Runqing , Sun Qi , Ding Jianguo , Li Wenlan , Li Wencai , Zhao Meng , Lu Shouping , Zeng Tingru , Zhang Hua , Zhao Suxian , Tie Shuanggui , Meng Zhaodong 
Published: October 2022

Abstract
Background
Maize rough dwarf disease (MRDD), caused by rice black-streaked dwarf virus (RBSDV) belonging to the Fijivirus genus, seriously threatens maize production worldwide. Three susceptible varieties (Ye478, Zheng 58, and Zhengdan 958) and two resistant varieties (P138 and Chang7–2) were used in our study.

Results
A set of ATP-binding cassette subfamily B (ABCB) transporter genes were screened to evaluate their possible involvements in RBSDV resistance. In the present study, ZmABCB15, an ABCB transporter family member, was cloned and functionally identified. Expression analysis showed that ZmABCB15 was significantly induced in the resistant varieties, not in the susceptible varieties, suggesting its involvement in resistance to the RBSDV infection. ZmABCB15 gene encodes a putative polar auxin transporter containing two trans-membrane domains and two P-loop nucleotide-binding domains. Transient expression analysis indicated that ZmABCB15 is a cell membrance localized protein. Over-expression of ZmABCB15 enhanced the resistance by repressing the RBSDV replication ratio. ZmABCB15 might participate in the RBSDV resistance by affecting the homeostasis of active and inactive auxins in RBSDV infected seedlings.

Conclusions
Polar auxin transport might participate in the RBSDV resistance by affecting the distribution of endogenous auxin among tissues. Our data showed the involvement of polar auxin transport in RBSDV resistance and provided novel mechanism underlying the auxin-mediated disease control technology.