bluuebunny/crossref_metadata_2025_split huggingface dataset:
FTY720 in resistant human epidermal growth factor receptor 2-positive breast cancer
Authors: Chung Wei-Pang , Huang Wei-Lun , Liao Wei-An , Hung Chun-Hua , Chiang Chi-Wu , Cheung Chun Hei Antonio , Su Wu-Chou 
Published: January 2022

AbstractThe prognosis of patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer has considerably improved. However, no reliable treatment besides anti-HER2 strategies has been available. FTY720, a small-molecule compound used for treating refractory multiple sclerosis, has been reported to have beneficial effects against cancers. We therefore evaluated the efficacy of FTY720 in trastuzumab-resistant breast cancer cells and investigated the possible mechanism involved. This study evaluated morphological changes after FTY720 treatment. Antiproliferative WST-1 assays and LDH Cytotoxicity Assay Kits were used to determine the treatment effects of drugs, whereas Western blot analysis was used to evaluate protein expression. Apoptotic events were investigated through annexin V staining and TUNEL assays using flow cytometry. FTY720 was effective in trastuzumab-resistant breast cancer cell lines despite the presence of PIK3CA mutation. Studied on a xenograft mouse model, FTY720-treated groups had statistically significantly poorer HCC1954 xenograft growth in vivo compared with the control group. Our findings suggest that FTY720 can overcome resistance to trastuzumab therapy in patients with HER2-positive breast cancer, with FTY720 plus trastuzumab might offer even better efficacy in vitro and in vivo.
Bioepoxy based hybrid composites from nano-fillers of chicken feather and lignocellulose Ceiba Pentandra
Authors: Rangappa Sanjay Mavinkere , Parameswaranpillai Jyotishkumar , Siengchin Suchart , Jawaid Mohammad , Ozbakkaloglu Togay 
Published: January 2022

AbstractIn this work, fillers of waste chicken feather and abundantly available lignocellulose Ceiba Pentandra bark fibers were used as reinforcement with Biopoxy matrix to produce the sustainable composites. The aim of this work was to evaluate the mechanical, thermal, dimensional stability, and morphological performance of waste chicken feather fiber/Ceiba Pentandra bark fiber filler as potential reinforcement in carbon fabric-layered bioepoxy hybrid composites intended for engineering applications. These composites were prepared by a simple, low cost and user-friendly fabrication methods. The mechanical (tensile, flexural, impact, hardness), dimensional stability, thermal stability, and morphological properties of composites were characterized. The Ceiba Pentandra bark fiber filler-reinforced carbon fabric-layered bioepoxy hybrid composites display better mechanical performance compared to chicken feather fiber/Ceiba Pentandra bark fiber reinforced carbon fabrics layered bioepoxy hybrid composites. The Scanning electron micrographs indicated that the composites exhibited good adhesion at the interface of the reinforcement material and matrix system. The thermogravimetric studies revealed that the composites possess multiple degradation steps, however, they are stable up to 300 °C. The thermos-mechanical studies showed good dimensional stability of the composites. Both studied composites display better thermal and mechanical performance compared to neat bioepoxy or non-bioepoxy thermosets and are suitable for semi-structural applications.
Ensemble learning from ensemble docking: revisiting the optimum ensemble size problem
Authors: Mohammadi Sara , Narimani Zahra , Ashouri Mitra , Firouzi Rohoullah , Karimi‐Jafari Mohammad Hossein 
Published: January 2022

AbstractDespite considerable advances obtained by applying machine learning approaches in protein–ligand affinity predictions, the incorporation of receptor flexibility has remained an important bottleneck. While ensemble docking has been used widely as a solution to this problem, the optimum choice of receptor conformations is still an open question considering the issues related to the computational cost and false positive pose predictions. Here, a combination of ensemble learning and ensemble docking is suggested to rank different conformations of the target protein in light of their importance for the final accuracy of the model. Available X-ray structures of cyclin-dependent kinase 2 (CDK2) in complex with different ligands are used as an initial receptor ensemble, and its redundancy is removed through a graph-based redundancy removal, which is shown to be more efficient and less subjective than clustering-based representative selection methods. A set of ligands with available experimental affinity are docked to this nonredundant receptor ensemble, and the energetic features of the best scored poses are used in an ensemble learning procedure based on the random forest method. The importance of receptors is obtained through feature selection measures, and it is shown that a few of the most important conformations are sufficient to reach 1 kcal/mol accuracy in affinity prediction with considerable improvement of the early enrichment power of the models compared to the different ensemble docking without learning strategies. A clear strategy has been provided in which machine learning selects the most important experimental conformers of the receptor among a large set of protein–ligand complexes while simultaneously maintaining the final accuracy of affinity predictions at the highest level possible for available data. Our results could be informative for future attempts to design receptor-specific docking-rescoring strategies.
Unveiling the substructure of the massive clump AGAL G035.1330−00.7450
Authors: Ortega M. E. , Marinelli A. , Isequilla N. L. , Paron S. 
Published: January 2022

Context. It is known that high-mass stars form as the result of the fragmentation of massive molecular clumps. However, it is not clear whether this fragmentation gives rise to cores that are massive enough to directly form high-mass stars, or if leads to cores of low and intermediate masses that generate high-mass stars by acquiring material from their environment.
Aims. Detailed studies of massive clumps at the early stage of star formation are needed to collect observational evidence that sheds light on the fragmentation processes from clump to core scales. The infrared-quiet massive clump AGAL G035.1330−00.7450 (AGAL35) located at a distance of 2.1 kpc is a promising object for studying the fragmentation and the star formation activity at early stages.
Methods. Using millimeter observations of continuum and molecular lines obtained from the Atacama Large Millimeter Array database at Bands 6 and 7, we studied the substructure of the source AGAL35. The angular resolution of the data at Band 7 is about 0.′′7, which allowed us to resolve structures of about 0.007 pc (~1500 au).
Results. The continuum emission at Bands 6 and 7 shows that AGAL35 harbors four dust cores, labeled C1 to C4, with masses lower than 3 M⊙. Cores C3 and C4 exhibit well-collimated, young, and low-mass molecular outflows related to molecular hydrogen emission-line objects that were previously detected. Cores C1 and C2 present CH3CN J = 13–12 emission, from which we derive rotational temperatures of about 180 and 100 K, respectively. These temperatures allow us to estimate masses of about 1.4 and 0.9 M⊙ for C1 and C2, respectively, which are about an order of magnitude lower than those estimated in previous works and agree with the Jeans mass of this clump. In particular, the moment 1 map of CH3CN emission suggests the presence of a rotating disk towards C1, which is confirmed by the CH3OH and CH3OCHO (20–19) emissions. On the other hand, the CN N = 2–1 emission shows a clumpy and filamentary structure that seems to connect all the cores. These filaments might be tracing the remnant gas of the fragmentation processes taking place within the massive clump AGAL35 or the gas that is being transported toward the cores, which would imply a competitive accretion scenario.
Conclusions. The massive clump AGAL35 harbors four low- to intermediate-mass cores with masses lower than 3 M⊙, which is about an order of magnitude smaller than the masses estimated in previous works. This study shows that in addition to the importance of high-resolution and sensitivity observations for a complete detection of all fragments, it is very important to accurately determine the temperature of these cores for a correct mass estimation. Finally, although no high-mass cores were detected toward AGAL35, the filamentary structure connecting all the cores means that high-mass stars might form through the competitive accretion mechanism.
A WISE view on extreme AGB stars
Authors: Groenewegen M. A. T. 
Published: January 2022

Context. Variability is a key property of stars on the asymptotic giant branch (AGB). Their pulsation period is related to the luminosity and mass-loss rate (MLR) of the star. Long-period variables (LPVs) and Mira variables are the most prominent of all types of variability of evolved stars. However, the reddest, most obscured AGB stars are too faint in the optical and have eluded large variability surveys.
Aims. Our goal is to obtain a sample of LPVs with large MLRs by analysing WISE W1 and W2 light curves (LCs) for about 2000 sources, photometrically selected to include known C-stars with the 11.3 μm silicon carbide dust feature in absorption, and Galactic O-stars with periods longer than 1000 days.
Methods. Epoch photometry was retrieved from the AllWISE and NEOWISE database and fitted with a sinus curve. Photometry from other variability surveys was also downloaded and fitted. For a subset of 316 of the reddest stars, spectral energy distributions (SEDs) were constructed, and, together with mid-infrared (MIR) spectra when available, fitted with a dust radiative transfer programme in order to derive MLRs.
Results. WISE based LCs and fits to the data are presented for all stars. Periods from the literature and periods from refitting other literature data are presented. The results of the spatial correlation with several (IR) databases is presented. About one-third of the sources are found to be not real, but it appears that these cannot be easily filtered out by using WISE flags. Some are clones of extremely bright sources, and in some cases the LCs show the known pulsation period. Inspired by a recent paper, a number of non-variable OH/IRs are identified. Based on a selection on amplitude, a sample of about 750 (candidate) LPVs is selected of which 145 have periods > 1000 days, many of them being new. For the subset of the stars with the colours of C-rich extremely red objects (EROs) the fitting of the SEDs (and available MIR spectra) separates them into C- and O-rich objects. Interestingly, the fitting of MIR spectra of mass-losing C-stars is shown to be a powerful tracer of interstellar reddening when AV ≳ 2 mag. The number of Galactic EROs appears to be complete up to about 5 kpc and a total dust return rate in the solar neighbourhood for this class is determined. In the LMC 12 additional EROs are identified. Although this represents only about 0.15% of the total known LMC C-star population adding their MLRs increases the previously estimated dust return by 8%. Based on the EROs in the Magellanic Clouds, a bolometric period luminosity is derived. It is pointed out that due to their faintness, EROs and similar O-rich objects are ideal targets for a NIR version of Gaia to obtain distances, observing in the K-band or, even more efficiently, in the L-band.
Diagnostic Benefit of the Detection of Mitotic Figures in Endometriotic Lesions
Authors: Wetzk Michelle , Grübling Nannette , Forberger Almuth , Klengel Jörg , Kuhlmann Jan Dominik , Wimberger Pauline , Goeckenjan Maren 
Published: January 2022

Abstract
Objectives Endometriosis is a chronic disease which is diagnosed by surgical intervention combined with a histological work-up. Current international and national recommendations do
not require the histological determination of the proliferation rate. The diagnostic and clinical importance of the mitotic rate in endometriotic lesions still remains to be elucidated.
Methods In this retrospective study, the mitotic rates and clinical data of 542 patients with histologically diagnosed endometriosis were analyzed. The mean patient age was
33.5 ± 8.0 (17 – 72) years, and the mean reproductive lifespan was 21.2 ± 7.8 (4 – 41) years. Patients were divided into two groups and patientsʼ reproductive history and clinical
endometriosis characteristics were compared between groups. The study group consisted of women with confirmed mitotic figures (n = 140, 25.83%) and the control group comprised women without
proliferative activity according to their mitotic rates (n = 402, 74.27%).
Results Women with endometriotic lesions and histologically confirmed mitotic figures were significantly more likely to have a higher endometriosis stage (p = 0.001), deep
infiltrating endometriosis (p < 0.001), ovarian endometrioma (p = 0.012), and infertility (p = 0.049). A mitotic rate > 0 was seen significantly less often in cases with incidental
findings of endometriosis (p = 0.031). The presence of symptoms and basic characteristics such as age, age at onset of menarche, reproductive lifespan and parity did not differ between the
group with and the group without mitotic figures.
Conclusion This study shows that a simple histological assessment of the mitotic rate offers additional diagnostic value for the detection of advanced stages of endometriosis. The
possible role as a predictive marker for the recurrence of endometriosis or the development of endometriosis-associated cancer will require future study.
Fetale Alkoholspektrum-Störungen im Erwachsenenalter
– Ergebnisse aus einer diagnostischen Sprechstunde
Authors: Sappok Tanja , Tergeist Marlene , Kruse Björn , Wagner Jessica 
Published: January 2022

Zusammenfassung
Ziel der Studie Fetale Alkoholspektrum-Störungen sind nicht nur
häufig, sie sind aufgrund des hohen Risikos für psychiatrische
Komorbiditäten auch im Erwachsenenalter klinisch relevant. Die
diagnostische Abklärung im Erwachsenenalter ist die Voraussetzung
für eine zielgerichtete Behandlung und bedarfsgerechte
Unterstützung.
Methodik In einer Metropolenregion wurde zwischen Mai 2015
und Juli 2020 bei 80 Personen der Verdacht auf eine FASD diagnostisch
abgeklärt. Die Ergebnisse dieser interdisziplinären Diagnostik
wurden systematisch ausgewertet und die klinischen Charakteristika der Personen
mit bzw. ohne FASD analysiert.
Ergebnisse Bei ca. 70% der
Inanspruchnahmepopulation wurde eine Diagnose aus dem FAS-Spektrum gestellt.
Personen mit FASD zeigten häufiger eine Lernbehinderung (50 vs.
33%) oder Intelligenzminderung (40 vs. 10%), während
keine Gruppenunterschiede für Alter und Geschlecht bestanden.
Psychiatrische Komorbiditäten, insbesondere Depressionen (39%)
und Abhängigkeitserkrankungen (31%), waren in beiden Gruppen
häufig.
Schlussfolgerung Im Rahmen einer multiprofessionellen
standardisierten Diagnostik ist die FASD Abklärung auch im
Erwachsenenalter möglich und nötig. Die Entwicklung
standardisierter und spezifischer Diagnosekriterien für Erwachsene ist
sinnvoll.
Mechanochemiluminescent Hydrogels for Real-Time Visualization of Chemical Bond Scission
Authors: Chen Yulan , Li Qing , Wang Qi , Yuan Yuan 
Published: January 2022

AbstractQuantitative and real-time characterization of mechanically induced bond-scission events taken place in polymeric hydrogels is essential to uncover their fracture mechanics. Herein, a class of mechanochemiluminescent swelling hydrogels have been synthesized through a facile micellar copolymerization method using chemiluminescent bisacrylate-modified bis(adamantyl)-1,2-dioxetane (Ad) as a crosslinker. This design and synthetic strategy ensure intense mechanochemiluminescence from Ad located in a hydrophobic network inside micelles. Moreover, the mechanochemiluminescent colors can be tailored from blue to red by mixing variant acceptors. Taking advantages of the transient nature of dioxetane chemiluminescence, the damage distribution and crack evolution of the hydrogels can be visualized and analyzed with high spatial and temporal resolution. The results demonstrate the strengths of the Ad mechanophore and micellar copolymerization method in the study of damage
evolution and fracture mechanism of swelling hydrogels.
Synthesis of Isoquinoline-1,3(2H,4H)-diones by Visible-Light-Mediated Cyclization of Acryloylbenzamides with Alkylboronic Acids, Arylsulfonyl Hydrazides and Oxime Esters
Authors: Cheng Dongping , Xu Xiaoliang , Fu Jiahui , Cai Xingxing , Liu Yihuo , Li Jinghua 
Published: January 2022

AbstractAn efficient visible-light-mediated tandem reaction of acryl­oylbenzamides with alkylboronic acids, arylsulfonyl hydrazides and oxime esters has been developed. The reaction proceeds via radical addition and cyclization to give various isoquinoline-1,3(2H,4H)-diones in satisfactory yields under mild conditions, which provides a good opportunity to discover new meaningful bioactive compounds.
Nasal mucoepidermoid carcinoma after radiotherapy: Case report
Authors: Nery Breno , Costa Victor Ribeiro Xavier , Pinto Glaudir Donato , Diniz Andrey Maia Silva , Freitas Lucas Ribeiro de Moraes , Leone Davi Coutinho Marcelino Guerra , Segundo José Alencar de Sousa , Enout Mariana Junqueira Reis , Quaggio Eduardo , Rivero Renan Lopez 
Published: January 2022

Abstract
Introduction Mucoepidermoid carcinoma (MEC) is a tumor originated from the epithelium of the glandular excretory ducts and has highly variable biological potential. It is the most prevalent cancer of the salivary glands. The present report aims to describe a case of nasal mucoepidermoid carcinoma that developed after adjuvant radiotherapy (RT) treatment of a recurrent pituitary macroadenoma.
Case Report Male patient, 62 years old, presented with recurrent nasal epistaxis on the right, associated with intense pulsatile headache, visual analogical scale (VAS) 10/10, with improvement only with the use of opioids and morphine. After undergoing oncological screening and study by imaging exams, the presence of an expansive seal lesion with suprasellar extension was seen, involving the medial wall of the cavernous segment of the right carotid artery and the anterior cerebral artery, as well as the presence of a new expansive lesion in the right nasal cavity, with ethmoid bone invasion superiorly and medial orbit wall invasion laterally, compressing the ipsilateral optic nerve canal.
Discussion Sinonasal neoplasms represent a small portion of all malignancies of the upper aerodigestive tract, accounting for < 5% of these neoplasms. The development of MEC involves risk factors such as occupational issues, history of trauma and surgery involving the nasal area, and radiation exposure, as in previous RT.
Conclusion Mucoepidermoid carcinoma is an uncommon neoplasia and can be associated with RT treatment, as used in cases of recurrent pituitary macroadenoma. In general, surgical resection to obtain free margins of neoplastic tissue is the aimed treatment, seeking better prognosis.
Sporadic Intradural Extramedullary Hemangioblastoma of Cauda Equina with Large Peritumoral Cyst—A Rare Presentation
Authors: Thippeswamy Pushpa B. , Soundararajan Dilip C. R. , Kanna Ríshi M. , Kuna Venkata S. , Rajasekaran Shanmuganathan 
Published: January 2022

AbstractCauda equina intradural tumors commonly reported include ependymoma, schwannoma, neurofibroma, meningioma, and drop metastasis. Hemangioblastoma of the neural axis is a rare benign vascular tumor comprising only 1.6 to 6.4% of spinal tumors, and are usually associated with Von-Hippel Lindau disease. Sporadic intradural extramedullary hemangioblastoma involving cauda equina is very rare with only countable reports, and the presence of peritumoral cyst has been reported only once. We report one such case of hemangioblastoma with a large peritumoral cyst, which was diagnosed radiologically and confirmed by histopathology following surgical excision. Pertinent radiological characteristics, diagnostic clues, treatment, and surgical outcomes are discussed.
Isolated Complete Distal Biceps Femoris Tendon Tears: Case Series and Literature Review
Authors: Azzopardi Christine , Beale David , James Steven L. , Botchu Rajesh 
Published: January 2022

AbstractThe Biceps femoris is a vital component of the posterolateral corner of the knee. We report two cases of isolated rupture of the biceps femoris, discuss the possible mechanism of injury, and review the literature.
Gastroschisis: Impact of Bedside Closure on Ventilator-Associated Outcomes
Authors: Campbell Alison Morag , Motawea Mahmoud , Fradley Wayne , Marven Sean 
Published: January 2022

Abstract
Aim In our practice, preformed silos are routine rather than reserved for difficult cases. We aimed to identify whether silo and bedside closure can minimize: general anesthetic (GA) exposure, need for intubation and ventilation, or days intubated for neonates with simple gastroschisis (SG).
Methods After approval, patients were identified via the neonatal discharge log (April 2010 to April 2019). Data were collected by case-note review and analyzed with respect to GA, ventilation, and core outcomes.
Results Of 104 patients (50 female, mean birth weight 2.43 kg, mean gestational age 36 + 2 weeks), 85 were SG and 19 complex. Silo application was initial management in 70 SG, 57 completed successful bedside closure (by day 4 of life—median). Fifteen SG had initial operative closure.Of the 70 SG managed with silo, 46 (66%) had no GA as neonates. Twelve required GA for line insertion. Thirteen patients with initial silo had closure in theater (7 opportunistic at time of GA for line). Nine required intubation and ventilation out-with the operating theater during neonatal management. Seven had already been intubated at delivery; 3 because of meconium aspiration.One-hundred percent of those treated with operative closure had GA, 1 patient subsequently required surgery for subglottic stenosis. Time to full feeds did not differ between groups.
Conclusion Silo and bedside closure allow the majority of SG neonates to avoid GA or intubation in the neonatal period, without increased risk of complication. However, it is important that the nursing expertise required to manage these patients safely is not underestimated.
Time-Lapse Systems: A Comprehensive Analysis on Effectiveness
Authors: Fadon Patricia , Gallegos Eleanor , Jalota Salonika , Muriel Lourdes , Diaz-Garcia Cesar 
Published: January 2022

AbstractTime-lapse systems have quickly become a common feature of in vitro fertilization laboratories all over the world. Since being introduced over a decade ago, the alleged benefits of time-lapse technology have continued to grow, from undisturbed culture conditions and round the clock, noninvasive observations to more recent computer-assisted selection of embryos through the development of algorithms. Despite the global uptake of time-lapse technology, its real impact on clinical outcomes is still controversial. This review aims to explore the different features offered by time-lapse technology, discussing incubation, algorithms, artificial intelligence and the regulation of nonessential treatment interventions, while assessing evidence on whether any benefit is offered over conventional technology.