bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regionalism as development: The Lomé Conventions I and II (1975–1985)
Authors: Sakr Rafael Lima 
Published: November 2022

AbstractLomé Conventions I (1975) and II (1979) were the first regional trade agreements (RTAs) between the European Community (EC) and the group of postcolonial countries in Africa, the Caribbean, and Pacific (ACP). Specialized scholarship offers rich analyses of those Conventions; however, little is known about the role of law and lawyers in their making, and their relevance for present-day debates about RTAs.This article advances existing knowledge in two ways. First, it historicizes the more visible role of law in constituting Lomé as a legal regime for governing EC-ACP regionalism. It then argues that the Conventions were distinct from existing RTAs due to their unique centrality on social and economic development; and from present-day RTAs, because they were conceived not simply as instrumental to but also as constitutive of development.Second, by historicizing the less visible role of law and lawyers in the Lomé regime, the article identifies that a specialist conception of South-North RTAs was refined to govern which ideas, projects, norms, and institutions were applicable to Lomé. This distinct conception – called the development framework – was critical in creating the conditions of possibility for decision-makers negotiate, interpret, and manage the Conventions.Those findings challenge conventional wisdom on two grounds. They suggest that Lomé was unique not for embodying a new model but for consolidating the development framework’s dominance. They contest present-day understanding of RTAs as textual manifestations of a universal concept by demonstrating the existence of competing conceptions, which express distinct notions of RTAs’ purpose, content, and form.
On random walks and switched random walks on homogeneous spaces
Authors: Moreno Elvira , Velasco Mauricio 
Published: November 2022

AbstractWe prove new mixing rate estimates for the random walks on homogeneous spaces determined by a probability distribution on a finite group$G$. We introduce the switched random walk determined by a finite set of probability distributions on$G$, prove that its long-term behaviour is determined by the Fourier joint spectral radius of the distributions, and give Hermitian sum-of-squares algorithms for the effective estimation of this quantity.
Prehospital Preparedness for Major Incidents in Sweden: A National Survey with Focus on Mass-Casualty Incidents
Authors: Agri Joakim , Söderin Louise , Hammarberg Elsa , Lennquist-Montán Kristina , Montán Carl 
Published: November 2022

AbstractIntroduction:Major incidents (MIs) put great demands on the medical response to effectively organize and redistribute resources and personnel, in prehospital care as well as hospital care, and coordinating functions. Studies indicate that regular training and well-established contingency plans are vital for the medical response to MIs. Previous assessments have concluded that Swedish disaster preparedness requires improved organization and coordination. There is currently no method to easily follow-up the preparedness work of the prehospital medical response organizations for MIs in Sweden.Problem:The aim of the study was to assess qualifications and training requirements for central individual roles, to examine frequency and focus of training and simulation, as well as to examine current regional routines for MIs in Sweden. The aim was also to identify, to evaluate, and to investigate areas for improvement in prehospital health care preparedness for MIs in Sweden.Methods:Descriptive comparative study of Sweden’s prehospital organization, planning, education, and training for MIs through a web-based survey sent to all 21 regions in Sweden. The survey included 64 questions and was based on national legislation and guidelines for preparedness and previous investigations of real MIs.Results:A total of 37 answers to the survey were collected representing 17/21 regions (80.9%) from which Regional Management Individuals (RMIs) were selected from 15 regions and used as representative primary responses. The initial routines regarding alarm and establishment of management functions were mainly in-line with national guidelines. Staffing and qualification requirements for certain leadership roles differed substantially between regions. The requirements for the health care staff’s knowledge of the contingency plan were generally low and routines for follow-up were often lacking. The frequency of exercises in certain areas were deficient.Conclusions:The results of the study showed several potential areas for improvement within the prehospital emergency medical preparedness for MIs in Sweden. Methodology and adherence of national guidelines for medical response preparedness differ between regions in Sweden, which motivates recurring assessments. It is possible to use a well-prepared questionnaire study to follow-up and to examine parts of the regional prehospital preparedness work and organization for MIs.
Musical Messaging: The Social and Anti-Social Affordances of WhatsApp in the Football Culture of the Latin American Southern Cone
Authors: ACHONDO LUIS 
Published: November 2022

AbstractArgentine, Chilean, and Uruguayan hinchas (soccer or football supporters) cheer for their teams primarily through contrafacta of popular music. Until recently, chants were mainly composed in stadiums and other physical spaces of fan socialization. However, the increasing dominance of the messaging app WhatsApp has altered these sociomusical relations. Drawing on ethnographic work, I argue that the messaging app has fostered both sociality and anti-sociality within and between fanbases. Hinchas employ its creative affordances to digitally decentre creativity from individuals through the distribution of inventive tasks between different people. However, WhatsApp also contributes to football violence by intimately spreading hate memes, aggressive chants, and videos of torture, among other forms of violent media. In illustrating that the messaging app can immerse and infect subjects in both productive and destructive relationalities, this article ultimately underscores the social and anti-social potentialities of viral media and digital technologies.
“I'mpossible”: Some challenges of implementing international law in the area of humanitarian affairs for persons with disabilities
Authors: Maltez Mar 
Published: November 2022

AbstractPersons with disabilities are entitled to certain protections under international law, including in the context of armed conflict. These individuals are especially vulnerable in a crisis situation. Too often, when emergency humanitarian relief is provided, these protections are afforded inadequately or not at all, due to personal prejudice, lack of resources or training, or because there is no systemic requirement to do so. This paper uses a narrative-based approach to illustrate typical lived experiences of persons with disabilities both as workers in the area of humanitarian relief, and recipients thereof. It illustrates the challenges and inadequacies of a system that fails to recognize the rights that should be provided to those with physical and/or neurodevelopmental differences. It highlights the discrepancy between legal rights and actual provision of service and the different needs of those with disabilities in the circumstance of armed conflict. The article points to specific areas of failure, and the need for an inclusive approach in programming.
Formative assessment and key competences for a conscious recovery after COVID-19: an Action-Research at a school in Italy to enhance reflection starting from mistakes
Authors: Canfarotta Daniela , Lojacono Carla 
Published: November 2022

AbstractThe study presents the results of an Action-Research project carried out during the COVID-19 pandemic with Italian teachers of primary, lower and upper secondary schools, interested in monitoring the activity of students in that difficult situation. The purposes of this study were: (a) to demonstrate that the involvement of teachers in the creation of metacognitive tools promotes the use of formative assessment at school; (b) to verify to what extent the use of a metacognitive form makes students more aware of the mistakes made during the test. The results were: (a) teachers showed great enthusiasm in adapting the metacognitive form to their school subject; (b) students pointed out high percentages of appreciation of the form; what is more, a group of students improved in identifying the typology of errors and understood more clearly what they should study in a better way to correct their mistakes; another group noted that their awareness of their strengths in study method had grown; finally, one group highlighted that the skills used during the completion of the form were also useful in other areas of their daily life, not only at school. Both teachers and students appreciated the online version of the tool: the pie charts created automatically by the system, by displaying percentages over typologies of errors made, provided immediate feedback, motivating students more and more. The study shows how much reflection on mistakes can be a source of growth.
Stormtime Ring Current Heating of the Ionosphere and Plasmasphere
Authors: Krall J. , Fok M.‐C. , Huba J. D. , Glocer A. 
Published: November 2022

AbstractThe energy deposition from ring current ions into the high density “cold” plasma of the ionosphere and plasmasphere is analyzed, based on a Comprehensive Inner Magnetosphere‐Ionosphere simulation of the 2015 October 7 storm. In addition, the Naval Research Laboratory Sami3 is Also a Model of the Ionosphere ionosphere/plasmasphere code is used to simulate the effect of Coulomb‐collision heating of plasmasphere and ionosphere electrons by ring current ions. We find that, during stormtime peaks in the Dst index, energy is deposited at altitudes as low as 100 km. Heating along the entirety of any given field line, both in the ionosphere and plasmasphere, contributes to increased temperatures in the ionosphere F layer and inner magnetosphere and to subsequent cold O+ outflows. However, relative to the heating of the plasmasphere, the direct heating of the ionosphere by ring current ions produces only small effects. Qualitative model‐data agreement on the N+/O+ density ratio is consistent with the hypothesis that these outflows are driven by thermal forcing.
Diagnostic Analysis of the Physical Processes Underlying the Long‐Duration O/N2 Depletion During the Recovery Phase of the 8 June 2019 Geomagnetic Storm
Authors: Yu Tingting , Wang Wenbin , Ren Zhipeng , Cai Xuguang , Liu Libo , He Maosheng , Pedatella Nicholas , Zhai Changzhi 
Published: November 2022

AbstractA thermospheric O and N2 column density ratio (∑O/N2) depletion with long‐duration (>16 hr) was observed by the Global‐scale Observations of the Limb and Disk at the Atlantic longitudes (75W–20W) and middle latitudes (20N–50N) during the recovery phase of the 8 June 2019 geomagnetic storm. The National Center for Atmospheric Research Thermosphere Ionosphere Electrodynamics General Circulation Model (TIEGCM) simulations reproduced the ∑O/N2 depletion patterns with a similar magnitude, and indicated that the composition recovery at middle latitudes began several hours after the beginning of the recovery phase of the geomagnetic storm. The TIEGCM simulations enable quantitative analysis of the physical mechanisms driving the middle‐latitude composition changes during the storm recovery phase. This analysis indicates that vertical advection and molecular diffusion dominated the initial recovery of composition perturbations at middle latitudes. Horizontal advection was also a main driver in the initial recovery of composition, but its contribution decreased rapidly. In the late recovery phase, the composition recovery was mainly determined by horizontal advection. In comparison, vertical advection and molecular diffusion played a much less important role.
Statistical Analysis of Aquifer Hydraulic Properties by a Continuous Pumping Tomography Test: Application to the Boise Hydrogeophysical Research Site
Authors: Cheng Kan Bun , Dagan Gedeon , Barrash Warren , Cardiff Michael , Rabinovich Avinoam 
Published: November 2022

AbstractCharacterizing aquifer heterogeneity is paramount for accurate flow and transport modeling. In this work, we present a new approach for statistical analysis of hydraulic properties in continuous pumping tomography tests of a phreatic aquifer. The method entails determining equivalent hydraulic conductivity (Keq), specific storage (Ss,eq), and specific yield (Sy,eq) at many locations in the field and then calculating statistical moments of the equivalent properties, assuming they are random space variables. Equivalent properties are defined as the ones pertinent to a homogeneous aquifer for which the head time dependent signal fits the one observed in the pumping test. Calculation is carried out in a novel approach, by matching measured head data to two separate semianalytical solutions considering two time periods, early and late. We apply this approach to the Boise Hydrogeophysical Research Site and find that the equivalent property spatial averages decrease with horizontal distance from the pumping well and appear to stabilize at sufficiently large distances, in line with existing theory for Keq. The squared coefficient of variation shows similar behavior, with values indicating a weakly heterogeneous aquifer. Furthermore, estimated values for Keq, Ss,eq, and Sy,eq are in agreement with literature values for the site.
Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury
Authors: Yang Hui-Hui , Jiang Hui-Ling , Tao Jia-Hao , Zhang Chen-Yu , Xiong Jian-Bing , Yang Jin-Tong , Liu Yu-Biao , Zhong Wen-Jing , Guan Xin-Xin , Duan Jia-Xi , Zhang Yan-Feng , Liu Shao-Kun , Jiang Jian-Xin , Zhou Yong , Guan Cha-Xiang 
Published: November 2022

AbstractNecroptosis is the major cause of death in alveolar epithelial cells (AECs) during acute lung injury (ALI). Here, we report a previously unrecognized mechanism for necroptosis. We found an accumulation of mitochondrial citrate (citratemt) in lipopolysaccharide (LPS)-treated AECs because of the downregulation of Idh3α and citrate carrier (CIC, also known as Slc25a1). shRNA- or inhibitor–mediated inhibition of Idh3α and Slc25a1 induced citratemt accumulation and necroptosis in vitro. Mice with AEC-specific Idh3α and Slc25a1 deficiency exhibited exacerbated lung injury and AEC necroptosis. Interestingly, the overexpression of Idh3α and Slc25a1 decreased citratemt levels and rescued AECs from necroptosis. Mechanistically, citratemt accumulation induced mitochondrial fission and excessive mitophagy in AECs. Furthermore, citratemt directly interacted with FUN14 domain-containing protein 1 (FUNDC1) and promoted the interaction of FUNDC1 with dynamin-related protein 1 (DRP1), leading to excessive mitophagy-mediated necroptosis and thereby initiating and promoting ALI. Importantly, necroptosis induced by citratemt accumulation was inhibited in FUNDC1-knockout AECs. We show that citratemt accumulation is a novel target for protection against ALI involving necroptosis.
Anlotinib enhances the antitumor immunity of radiotherapy by activating cGAS/STING in non-small cell lung cancer
Authors: Han Dong , Zhang Jiajia , Bao Yawei , Liu Lei , Wang Ping , Qian Dong 
Published: November 2022

AbstractRadiation resistance and unsatisfactory efficacy of radioimmunotherapy are important barriers to non-small cell lung cancer (NSCLC) treatment. The impacts of anlotinib on radiation and tumor immune microenvironment (TIME) in NSCLC remain to be resolved. Here, we find anlotinib enhances radiosensitivity, and further increases radiotherapy-stimulated CD8+ T cell infiltration and activation via triggering cGAS/STING pathway. Moreover, anlotinib shows significant effects on radioimmunotherapy (radiotherapy plus anti-PD-L1). The addition of anlotinib alleviates CD8+ T cell exhaustion, promotes the cytotoxicity and proliferation of CD8+ T cells, and boosts immune memory activation. Our work reveals the crucial role of anlotinib in antitumor immunity, and provides preclinical evidence for the application of anlotinib combined with radioimmunotherapy in NSCLC treatment.
Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli
Authors: Cox Dezerae , Ormsby Angelique R. , Reid Gavin E. , Hatters Danny M. 
Published: November 2022

AbstractThe correct spatio-temporal organization of the proteome is essential for cellular homeostasis. However, a detailed mechanistic understanding of this organization and how it is altered in response to external stimuli in the intact cellular environment is as-yet unrealized. ‘Protein painting methods provide a means to address this gap in knowledge by monitoring the conformational status of proteins within cells at the proteome-wide scale. Here, we demonstrate the ability of a protein painting method employing tetraphenylethene maleimide (TPE-MI) to reveal proteome network remodeling in whole cells in response to a cohort of commonly used pharmacological stimuli of varying specificity. We report specific, albeit heterogeneous, responses to individual stimuli that coalesce on a conserved set of core cellular machineries. This work expands our understanding of proteome conformational remodeling in response to cellular stimuli, and provides a blueprint for assessing how these conformational changes may contribute to disorders characterized by proteostasis imbalance.
Potential use of engineered nanoparticles in ocean fertilization for large-scale atmospheric carbon dioxide removal
Authors: Babakhani Peyman , Phenrat Tanapon , Baalousha Mohammed , Soratana Kullapa , Peacock Caroline L. , Twining Benjamin S. , Hochella Michael F. 
Published: November 2022

AbstractArtificial ocean fertilization (AOF) aims to safely stimulate phytoplankton growth in the ocean and enhance carbon sequestration. AOF carbon sequestration efficiency appears lower than natural ocean fertilization processes due mainly to the low bioavailability of added nutrients, along with low export rates of AOF-produced biomass to the deep ocean. Here we explore the potential application of engineered nanoparticles (ENPs) to overcome these issues. Data from 123 studies show that some ENPs may enhance phytoplankton growth at concentrations below those likely to be toxic in marine ecosystems. ENPs may also increase bloom lifetime, boost phytoplankton aggregation and carbon export, and address secondary limiting factors in AOF. Life-cycle assessment and cost analyses suggest that net CO2 capture is possible for iron, SiO2 and Al2O3 ENPs with costs of 2–5 times that of conventional AOF, whereas boosting AOF efficiency by ENPs should substantially enhance net CO2 capture and reduce these costs. Therefore, ENP-based AOF can be an important component of the mitigation strategy to limit global warming.
Structures of the holo CRISPR RNA-guided transposon integration complex
Authors: Park Jung-Un , Tsai Amy Wei-Lun , Rizo Alexandrea N. , Truong Vinh H. , Wellner Tristan X. , Schargel Richard D. , Kellogg Elizabeth H. 
Published: November 2022

AbstractCRISPR-associated transposons (CAST) are programmable mobile genetic elements that insert large DNA cargos using an RNA-guided mechanism1–3. CAST elements contain multiple conserved proteins: a CRISPR effector (Cas12k or Cascade), a AAA+ regulator (TnsC), a transposase (TnsA–TnsB) and a target-site-associated factor (TniQ). These components are thought to cooperatively integrate DNA via formation of a multisubunit transposition integration complex (transpososome). Here we reconstituted the approximately 1 MDa type V-K CAST transpososome from Scytonema hofmannii (ShCAST) and determined its structure using single-particle cryo-electon microscopy. The architecture of this transpososome reveals modular association between the components. Cas12k forms a complex with ribosomal subunit S15 and TniQ, stabilizing formation of a full R-loop. TnsC has dedicated interaction interfaces with TniQ and TnsB. Of note, we observe TnsC–TnsB interactions at the C-terminal face of TnsC, which contribute to the stimulation of ATPase activity. Although the TnsC oligomeric assembly deviates slightly from the helical configuration found in isolation, the TnsC-bound target DNA conformation differs markedly in the transpososome. As a consequence, TnsC makes new protein–DNA interactions throughout the transpososome that are important for transposition activity. Finally, we identify two distinct transpososome populations that differ in their DNA contacts near TniQ. This suggests that associations with the CRISPR effector can be flexible. This ShCAST transpososome structure enhances our understanding of CAST transposition systems and suggests ways to improve CAST transposition for precision genome-editing applications.
A scoping review and meta-analysis on the prevalence of pan-tumour biomarkers (dMMR, MSI, high TMB) in different solid tumours
Authors: Kang Yoon-Jung , O’Haire Sophie , Franchini Fanny , IJzerman Maarten , Zalcberg John , Macrae Finlay , Canfell Karen , Steinberg Julia 
Published: November 2022

AbstractImmune checkpoint inhibitors have been approved in the USA for tumours exhibiting mismatch repair deficiency (dMMR), microsatellite instability (MSI), or high tumour mutational burden (TMB), with regulatory and reimbursement applications in multiple other countries underway. As the estimated budget impacts of future reimbursements depend on the size of the potential target population, we performed a scoping review and meta-analysis of the prevalence of these pan-tumour biomarkers in different cancers. We systematically searched Medline/Embase and included studies reporting the prevalence of dMMR/MSI/high TMB in solid tumours published 01/01/2018–31/01/2021. Meta-analyses were performed separately for the pan-cancer prevalence of each biomarker, and by cancer type and stage where possible. The searches identified 3890 papers, with 433 prevalence estimates for 32 different cancer types from 201 studies included in meta-analyses. The pooled overall prevalence of dMMR, MSI and high TMB (≥ 10 mutations/Mb) in pan-cancer studies was 2.9%, 2.7% and 14.0%, respectively. The prevalence profiles of dMMR/MSI and high TMB differed across cancer types. For example, endometrial, colorectal, small bowel and gastric cancers showed high prevalence of both dMMR and MSI (range: 8.7–26.8% and 8.5–21.9%, respectively) and high TMB (range: 8.5–43.0%), while cervical, esophageal, bladder/urothelial, lung and skin cancers showed low prevalence of dMMR and MSI (< 5%), but high prevalence of high TMB (range: 23.7–52.6%). For other cancer types, prevalence of all three biomarkers was generally low (< 5%). This structured review of dMMR/MSI/high TMB prevalence across cancers and for specific cancer types and stages provide timely evidence to inform budget impact forecasts in health technology assessments for drug approvals based on these pan-tumour biomarkers.