bluuebunny/crossref_metadata_2025_split huggingface dataset:
The IRB Reliance Exchange (IREx): A national web-based platform for operationalizing single IRB review
Authors: Serdoz Emily Sheffer , Edwards Terri , Pulley Jill , Beadles Jenni , Ozier Julie , Harris Paul , Bernard Gordon R. , Rice Todd W. 
Published: March 2022

Abstract
For decades, the research community called for streamlined Institutional Review Board (IRB) review processes for multisite studies. Department of Health and Human Services and National Institutes of Health (NIH) recognized this need and implemented single IRB (sIRB) of record mandates. However, announcing mandates without sufficient operational guidance and tools is insufficient to foster the desired change. Nearly 4 years into implementation of the NIH’s sIRB mandate, operational challenges remain. Fortunately, NIH supports a web-based sIRB platform, the IRB Reliance Exchange (IREx), to facilitate sIRB communication and documentation. IREx has received continuous NIH funding supporting its evolution since 2011 and is now used by over 5,000 Human Research Protection Program and research personnel, 35 sIRBs, and 415 participating sites to operationalize sIRB review and approval on over 400 studies. IREx supports over 2300 reliance relationships with an average of 7 sites per study. The platform is continually used by sIRBs and relying sites, providing a valuable centralized portal for promoting a harmonized sIRB review process. IREx can promote transparency, standardize practice, minimize workflow variation, and mitigate the need for sIRBs to implement significant technical changes to their local electronic systems. IREx has proven to be nimble and adaptable with practice and policy changes over the past decade, as evidenced by continually increasing platform utilization.
Mutual Impacts of the COVID-19 Pandemic and the Recent Earthquakes: A Scoping Review of the Lessons Learned
Authors: Sayfouri Nasrin , Heidari Mohammad , Miresmaeeli Seyedeh Samaneh 
Published: March 2022

AbstractObjective:The aim of this study was to review the articles dealing with the mutual impacts of the coronavirus disease 2019 (COVID-19) pandemic and the recent earthquakes to elicit the various scopes of the lessons learned including the challenges, the successful measures, and the recommendations.Methods:To detect the relevant studies published between February 1, 2020, and June 9, 2021, PubMed, Web of Science, Scopus, and Google Scholar were searched. Having considered specific inclusion/exclusion criteria, 18 studies were included.Results:Seven major earthquakes have occurred concurrently or before the pandemic era in Albania, Croatia, Haiti, Great East Japan, Mexico, Nepal, and Utah. Thematic analysis revealed 5 themes for the “challenges” (management inefficiency, increased life-threatening, economic, socially related, and dual psychological challenges); 4 themes for the “efficient response measures” (health-care services measures, government measures, community-based cooperative activities, and disaster management response); and 3 major themes with 7 sub-themes for the “recommendations” including “the mitigation phase” (identifying probable natural disasters), “the preparedness phase” (preparing necessary equipment), and “the response phase” (mental care response measures, health-care-related COVID-19 measures, economic improvement measures, recognizing community-based capabilities, and government-related boosting measures).Conclusions:It is suggested that these scopes of the mutual impacts of the COVID-19 pandemic and the earthquakes be studied in systematic reviews.
Consequences of the German Constitutional Court’s Ruling on Germany’s Foreign Intelligence Service: The Importance of Human Rights in the Cooperation of Intelligence Services
Authors: Kappler Katrin 
Published: March 2022

AbstractIn 2020, Germany’s Federal Constitutional Court made a groundbreaking decision on foreign surveillance by the Federal Intelligence Service, the Bundesnachrichtendienst (BND). The Court’s first central finding was that the protection of fundamental rights is not limited to German territory. In addition, the ruling declared unconstitutional the regulations governing the transfer of information to foreign intelligence services. The ruling will therefore also have consequences for the cooperation of intelligence services, making it relevant abroad as well. In the ruling, the Court focused primarily on the role of human rights and ruled that the BND must check whether its cooperation partners respect human rights. The German parliament was given the task of implementing the Court’s demands. The law adopted in response to the Court’s demands came into force at the start of 2022. This article analyzes the ruling and the new law, and addresses the question what concrete requirements must be placed on the BND’s cooperation with foreign intelligence services.
Linking Money to Values: The New Rule of Law Conditionality Regulation and Its Constitutional Challenges
Authors: Baraggia Antonia , Bonelli Matteo 
Published: March 2022

AbstractIn December 2020, the EU institutions finally approved the new Rule of Law Conditionality Regulation after a controversial legislative process. The new Regulation allows the Commission and the Council to suspend EU funds in case of breaches to the rule of law that have negative effects on the EU budget and financial interests. This article analyses the new Regulation against the background of the rise of conditionality as a tool of EU governance. It argues, in contrast to some of the first analyses of the new Regulation, that the amendments adopted during the legislative process cannot simply be seen as a watered-down compromise, but were crucial to ensure the legality of the new instrument. At the same time, the EU’s growing reliance on conditionality continues to raise profound constitutional questions that still needs to be adequately addressed in the institutional and academic debate.
Political Understanding
Authors: Lepoutre Maxime 
Published: March 2022

AbstractPublic opinion research has shown that voters accept many falsehoods about politics. This observation is widely considered troubling for democracy – and especially participatory ideals of democracy. I argue that this influential narrative is nevertheless flawed because it misunderstands the nature of political understanding. Drawing on philosophical examinations of scientific modelling, I demonstrate that accepting falsehoods within one's model of political reality is compatible with – and indeed can positively enhance – one's understanding of that reality. Thus, the observation that voters accept many political falsehoods does not necessarily establish that they lack political understanding. I then address three worries: that voters cannot generally engage in such political modelling; that political modelling obscures facts that are crucial to political understanding; and that successful political modelling would require knowing that one's model contains falsehoods. My responses reveal how, going forward, we should measure political ignorance, and they highlight the standing importance of participatory democracy.
A narrowly endemic species of Begoniaceae: rediscovery, distribution and conservation ofBegonia jocelinoi
Authors: Paglia Isis , Luber Jaquelini , Mansano Vidal de Freitas , Freitas Leandro 
Published: March 2022

AbstractBegonia jocelinoiBrade (Begoniaceae) is a threatened species, endemic to a small locality in the Brazilian Atlantic Forest. The species was formerly listed as Wanted in the Red List of Endemic Flora of the state of Rio de Janeiro because it had not been recorded since 1953. After evaluating herbarium collections and conducting fieldwork during May 2019–February 2020, we report the rediscovery of a single population of 65 reproductive individuals ofB. jocelinoi, along with numerous seedlings, besides a trail in Itatiaia National Park. This Park is an IUCN category II protected area that permits some tourism activities. Some individuals ofB. jocelinoishowed signs of pruning following the maintenance of the trail. We recommend strategies for in situ and ex situ conservation of this narrowly endemic species, including provision of advice to tourists regarding the occurrence of threatened species, and diversion of the trail where the species occurs.
The Contested Right of Public Meeting in England from the Bill of Rights to the Public Order Acts
Authors: Navickas Katrina 
Published: March 2022

AbstractThe ‘right of public meeting’ has historically been a key demand of extra-parliamentary political movements in England. This paper examines how public assembly came to be perceived as a legally protected right, and how national and local authorities debated and policed political meetings. Whereas previous histories have suggested that a ‘liberal governance’ dominated urban government during the nineteenth century, this paper offers an alternative framework for understanding the relationship between people and the state. It points to rights paradoxes, whereby the right of free passage and to ‘air and recreation’ often conflicted with the demand for the right of political meeting in challenges to use of public spaces. Local authorities sought to defend the rights of property against political movements by using the common law offences of obstruction and ‘nuisance’. By the first half of the twentieth century, new threats of militant tactics and racial harassment by political groups necessitated specific public order legislation. Though twentieth-century legislation sought to protect certain types of assembly and protest marches, the implementation and policing of public order was spatially discriminatory, and the right of public meeting was left unresolved.
A call for comparing theories of consciousness and data sharing
Authors: Eagleman Sarah L. , Eagleman David M. , Menon Vinod , Meador Kimford J. 
Published: March 2022

AbstractMerker, Williford, and Rudrauf make several arguments against the integrated information theory of consciousness; whereas some have merit, their conclusion that the theory should be discarded is premature. Coming years promise advances in the empirical study of consciousness, and only after theories are independently tested with shared data can they be ruled in or out. We propose future research directions.
To be or to know? Information in the pristine present
Authors: Albantakis Larissa 
Published: March 2022

AbstractTo be true of every experience, the axioms of Integrated information theory (IIT) are necessarily basic properties and should not be “over-psychologized.” Information, for example, merely asserts that experience is specific, not generic. It does not require “access.” The information a system specifies about itself in its current state is revealed by its unfolded cause–effect structure and quantified by its integrated information.
Anatomical, physiological, and psychophysical data show that the nature of conscious perception is incompatible with the integrated information theory (IIT)
Authors: Gur Moshe 
Published: March 2022

AbstractThe integrated information theory (IIT) equates levels of consciousness with the amount of information integrated over the elements that constitute a system. Conscious visual perception provides two observations that contradict the IIT. First, objects are accurately perceived when presented for ≪100 ms during which time no neural integration is possible. Second, an object is seen as an integrated whole and, concurrently, all constituent elements are evident. Because integration destroys information about details, IIT cannot account for perceptual detail preservation.
IIT, half masked and half disfigured
Authors: Tononi Giulio , Boly Melanie , Grasso Matteo , Hendren Jeremiah , Juel Bjorn E. , Mayner William G. P. , Marshall William , Koch Christof 
Published: March 2022

AbstractThe target article misrepresents the foundations of integrated information theory (IIT) and ignores many essential publications. It, thus, falls to this lead commentary to outline the axioms and postulates of IIT and correct major misconceptions. The commentary also explains why IIT starts from phenomenology and why it predicts that only select physical substrates can support consciousness. Finally, it highlights that IIT's account of experience – a cause–effect structure quantified by integrated information – has nothing to do with “information transfer.”
Microhabitats, macro-differences: a survey of temperature records in Victoria Land terrestrial and freshwater environments
Authors: Cucini Claudio , Nardi Francesco , Magnoni Letizia , Rebecchi Lorena , Guidetti Roberto , Convey Peter , Carapelli Antonio 
Published: March 2022

AbstractThe temperature experienced by micro-invertebrates in extreme environments (such as those of Antarctica) is a pivotal parameter regarding these animals' ecology and physiology. However, at present, detailed knowledge of microhabitat physical conditions in Antarctica is limited, as well as being biased towards sub-Antarctic and Maritime Antarctic regions. To better understand the temperature conditions experienced in the microhabitats of Continental Antarctica by the native microfauna, we recorded temperatures year round in ponds and soils in an area of the Victoria Land coast and compared these measurements with air temperature data from the closest automatic weather station. We identified an important difference in temperature dynamics between the air, soil and pond datasets. Ponds were the warmest sites overall, differing by up to 7.5°C in comparison with the air temperature due to their greater thermal capacity, which also drove their patterns of freeze-thaw cycles and mean daily thermal excursion.
Improved feeds for log-periodic microstrip antenna arrays
Authors: Muduli Arjuna , Mishra Rabindra K. 
Published: March 2022

AbstractThis note proposes a log-periodic microstrip antenna (LPMA), particularly after developing possible feed structures. The process develops an appropriate feed such that the LPMA can exhibit almost end-fire characteristics such as a log-periodic dipole antenna. The study simulated two LPMAs, one with five elements and the other with seven elements, followed by measurements on a five-element prototype. The five-element prototype LPMA with such a feed exhibits a bandwidth of 2.2–3 GHz. Over this band, radiation patterns remain consistent with a gain of 9.8 dBi. Simulated results follow the measured ones closely.
Where did the Arizona‐Plano Go? Protracted Thinning Via Upper‐ to Lower‐Crustal Processes
Authors: Jepson Gilby , Carrapa Barbara , George Sarah W. M. , Reeher Lauren J. , Kapp Paul A. , Davis George H. , Thomson Stuart N. , Amadori Chiara , Clinkscales Christopher , Jones Sean , Gleadow Andrew J. W. , Kohn Barry P. 
Published: March 2022

AbstractMesozoic‐Cenozoic subduction of the Farallon slab beneath North America generated a regionally extensive orogenic plateau in the southwestern US during the latest Cretaceous, similar to the modern Central Andean Plateau. In Nevada and southern Arizona, estimates from whole‐rock geochemistry suggest crustal thicknesses reached ∼60–55 km by the Late Cretaceous. Modern crustal thicknesses are ∼28 km, requiring significant Cenozoic crustal thinning. Here, we compare detailed low‐temperature thermochronology from the Catalina metamorphic core complex (MCC) to whole rock Sr/Y crustal thickness estimates across southern Arizona. We identify three periods of cooling. A minor cooling phase occurred prior to ∼40 Ma with limited evidence of denudation and ∼10 km of crustal thinning. Major cooling occurred during detachment faulting and MCC formation at 26–19 Ma, corresponding to ∼8 km of denudation and ∼8 km of crustal thinning. Finally, we document a cooling phase at 17–11 Ma related to Basin and Range extension that corresponds with ∼5 km of denudation and ∼9 km of crustal thinning. During the MCC and Basin and Range extension events, the amount of denudation recorded by low‐temperature thermochronology can be explained by corresponding decreases in the crustal thickness. However, the relatively limited exhumation prior to detachment faulting at ∼26 Ma recorded by thermochronology is insufficient to explain the magnitude of crustal thinning (∼10 km) observed in the whole rock crustal thickness record. Therefore, we suggest that crustal thinning of the Arizona‐plano was facilitated via ductile mid‐ to lower‐crustal ﬂow, and limited upper‐crustal extension at 50–30 Ma prior to detachment faulting and Basin and Range extension.
Simulation of Geomagnetically Induced Currents in a Low‐Latitude 500 kV Power Network During a Solar Superstorm
Authors: Zhang J. J. , Yu Y. Q. , Chen W. Q. , Wang C. , Liu Y. D. , Liu C. M. , Liu L. G. 
Published: March 2022

AbstractGeomagnetically induced currents (GICs) are one of the main manifestations through which space weather affects human technical facilities, and GICs constitute the final link in the solar wind‐magnetosphere‐ionosphere‐ground interaction chain. Therefore, understanding the responses of power grids to solar superstorms is crucial for space weather research and emergency preparedness purposes. In this work, we combine the Space Weather Modeling Framework with a ground conductivity model and a model of the Chinese Guangdong 500 kV power grid to investigate the response of the whole power grid if the 23 July 2012 solar superstorm had struck the Earth. The maximum |GICs| produced in the power grid by this event reach approximately 400 A, which is more than thrice those measured during a strong magnetic storm with Kp = 8. Based on statistical analyses of the strength and duration of large GICs at 54 substations and a comparison with the GICs responsible for the Hydro‐Québec power outage on 13 March 1989, we stipulate that the risk of GICs in the Guangdong 500 kV power grid is very high. The simulation results also reveal that field‐aligned currents can play an important role in producing GICs in middle‐ and low‐latitude power grids during solar superstorms. This finding provides crucial insight for understanding the factors that generate strong GICs at middle and low latitudes.
Comparison of ultrashort pulse ablation of gold in air and water by time-resolved experiments
Authors: Spellauge Maximilian , Doñate-Buendía Carlos , Barcikowski Stephan , Gökce Bilal , Huber Heinz P. 
Published: March 2022

AbstractLaser ablation in liquids is a highly interdisciplinary method at the intersection of physics and chemistry that offers the unique opportunity to generate surfactant-free and stable nanoparticles from virtually any material. Over the last decades, numerous experimental and computational studies aimed to reveal the transient processes governing laser ablation in liquids. Most experimental studies investigated the involved processes on timescales ranging from nanoseconds to microseconds. However, the ablation dynamics occurring on a sub-nanosecond timescale are of fundamental importance, as the conditions under which nanoparticles are generated are established within this timeframe. Furthermore, experimental investigations of the early timescales are required to test computational predictions. We visualize the complete spatiotemporal picosecond laser-induced ablation dynamics of gold immersed in air and water using ultrafast pump-probe microscopy. Transient reflectivity measurements reveal that the water confinement layer significantly influences the ablation dynamics on the entire investigated timescale from picoseconds to microseconds. The influence of the water confinement layer includes the electron injection and subsequent formation of a dense plasma on a picosecond timescale, the confinement of ablation products within hundreds of picoseconds, and the generation of a cavitation bubble on a nanosecond timescale. Moreover, we are able to locate the temporal appearance of secondary nanoparticles at about 600 ps after pulse impact. The results support computational predictions and provide valuable insight into the early-stage ablation dynamics governing laser ablation in liquids.
GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling
Authors: Zhao Anjiang , Li Dan , Mao Xiongmin , Yang Mengliu , Deng Wuquan , Hu Wenjing , Chen Chen , Yang Gangyi , Li Ling 
Published: March 2022

AbstractG-protein gamma subunit 2 (GNG2) is involved in several cell signaling pathways, and is essential for cell proliferation and angiogenesis. However, the role of GNG2 in tumorigenesis and development remains unclear. In this study, 1321 differentially expressed genes (DEGs) in breast cancer (BC) tissues were screened using the GEO and TCGA databases. KEGG enrichment analysis showed that most of the enriched genes were part of the PI3K-Akt signaling pathway. We identified GNG2 from the first five DEGs, its expression was markedly reduced in all BC subtype tissues. Cox regression analysis showed that GNG2 was independently associated with overall survival in patients with luminal A and triple-negative breast cancers (TNBC). GNG2 over-expression could significantly block the cell cycle, inhibit proliferation, and promote apoptosis in BC cells in vitro. In animal studies, GNG2 over-expression inhibited the growth of BC cells. Further, we found that GNG2 significantly inhibited the activity of ERK and Akt in an MRAS-dependent manner. Importantly, GNG2 and muscle RAS oncogene homolog (MRAS) were co-localized in the cell membrane, and the fluorescence resonance energy transfer (FRET) experiment revealed that they had direct interaction. In conclusion, the interaction between GNG2 and MRAS likely inhibits Akt and ERK activity, promoting apoptosis and suppressing proliferation in BC cells. Increasing GNG2 expression or disrupting the GNG2–MRAS interaction in vivo could therefore be a potential therapeutic strategy to treat BC.
Ferroptosis in oligodendrocyte progenitor cells mediates white matter injury after hemorrhagic stroke
Authors: Shen Danmin , Wu Weihua , Liu Jing , Lan Ting , Xiao Zhongnan , Gai Kaiyuan , Hu Liye , Luo Zhaoli , Wei Chao , Wang Xiaotong , Lu Yabin , Wang Yamei , Zhang Chenguang , Wang Peipei , Zuo Zhentao , Yang Fei , Li Qian 
Published: March 2022

AbstractOligodendrocyte progenitor cells (OPCs) differentiate to myelin-producing mature oligodendrocytes and enwrap growing or demyelinated axons during development and post central nervous diseases. Failure of remyelination owing to cell death or undifferentiation of OPCs contributes to severe neurologic deficits and motor dysfunction. However, how to prevent the cell death of OPCs is still poorly understood, especially in hemorrhagic diseases. In the current study, we injected autologous blood into the mouse lateral ventricular to study the hemorrhage-induced OPC cell death in vivo. The integrity of the myelin sheath of the corpus callosum was disrupted post intraventricular hemorrhage (IVH) assessed by using magnetic resonance imaging, immunostaining, and transmission electron microscopy. Consistent with the severe demethylation, we observed massive cell death of oligodendrocyte lineages in the periventricular area. In addition, we found that ferroptosis is the major cell death form in Hemin-induced OPC death by using RNA-seq analysis, and the mechanism was glutathione peroxidase 4 activity reduction-resulted lipid peroxide accumulation. Furthermore, inhibition of ferroptosis rescued OPC cell death in vitro, and in vivo attenuated IVH-induced white matter injury and promoted recovery of neurological function. These data demonstrate that ferroptosis is an essential form of OPC cell death in hemorrhagic stroke, and rescuing ferroptotic OPCs could serve as a therapeutic target for stroke and related diseases.