bluuebunny/crossref_metadata_2025_split huggingface dataset:
A stochastic agent-based model to evaluate COVID-19 transmission influenced by human mobility
Authors: Chen Kejie , Jiang Xiaomo , Li Yanqing , Zhou Rongxin 
Published: November 2022

Abstract
The COVID-19 pandemic has created an urgent need for mathematical models that can project epidemic trends and evaluate the effectiveness of mitigation strategies. To forecast the transmission of COVID-19, a major challenge is the accurate assessment of the multi-scale human mobility and how they impact the infection through close contacts. By combining the stochastic agent-based modeling strategy and hierarchical structures of spatial containers corresponding to the notion of places in geography, this study proposes a novel model, Mob-Cov, to study the impact of human traveling behaviour and individual health conditions on the disease outbreak and the probability of zero COVID in the population. Specifically, individuals perform power-law type of local movements within a container and global transport between different-level containers. Frequent long movements inside a small-level container (e.g. a road or a county) and a small population size reduce the local crowdedness of people and the disease infection and transmission. In contrast, travels between large-level containers (e.g. cities and nations) facilitate global disease spread and outbreak. Moreover, dynamic infection and recovery in the population are able to drive the bifurcation of the system to a "zero-COVID" state or a "live with COVID" state, depending on the mobility patterns, population number and health conditions. Reducing total population and local people accumulation as well as restricting global travels help achieve zero-COVID. In summary, the Mob-Cov model considers more realistic human mobility in a wide range of spatial scales, and has been designed with equal emphasis on performance, low simulation cost, accuracy, ease of use and flexibility. It is a useful tool for researchers and politicians to investigate the pandemic dynamics and plan actions against the disease.
The effects of heading time on yield performance and HvGAMYB expression in spring barley subjected to drought
Authors: Ogrodowicz Piotr , Kuczyńska Anetta , Krajewski Paweł , Kempa Michał 
Published: November 2022

Abstract

In the lifetime of a plant, flowering is not only an essential part of the reproductive process but also a critical developmental stage that can be vulnerable to environmental stresses. To ensure survival during drought, plants accelerate the flowering process, and this response is known as „drought escape”.HvGAMYB– transcriptional factor associated, among others, with flowering process and anther development in barley has also an important role in developmental modification and yield performance in plants subjected to stressed conditions. However, there is limited information whether the mechanisms associated with the flowering acceleration may cause the anther or pollen disruption due to their influence on flower developmentvia GAMYBoverexpression. The aim of this study was to characterize differences in responses to drought among barley genotypes varied in terms of earliness. Two subgroups of barley plants differentiated in terms of phenology were analyzed, and a wide range of traits linked to plant morphology, physiology, and yield were investigated. The abiotic stress reactions of two barley plants subgroups varied in our study both in terms of yield, morphology, chlorophyll fluorescence kinetics and pollen viability. The results extend our knowledge aboutHvGAMYBexpression in anthers of barley plants grown under drought conditions and indicate the role of this transcription factor in shaping the yieldviainfluencing traits linked to spike morphology, especially in lateral stems. Hence, this gene could be regarded as an important factor in flowering process and, as a consequence, pollen and seed development in plants subjected to abiotic stress conditions. This study clearly show the important role ofHvGAMYBin survival mechanism associated with so called “drought escape strategy”.
The Moderating Role of Family Social Capital in the Relationship between Community Social Capital and Life Satisfaction among Older Adults in Northeast Rural China
Authors: Zhang Jingyue , Lu Nan 
Published: November 2022

Abstract
Background: This study examined the moderating effect of family social capital on the relationship between community social capital and life satisfaction among rural community-dwelling older adults in Northeast China.
Methods: Data were based on a social survey in the rural communities of Northeast China in late 2019. The analytic model included 455 respondents who completed the survey successfully. We used multiple-group analysis to test the proposed hypotheses.
Results: The results show that family social capital played a significant moderating role in the relationship between community social capital and life satisfaction. In other words, both cognitive social capital and social participation were significantly associated with life satisfaction in the higher family social capital group, whereas these associations were not significant among those with relatively lower levels of family social capital.
Conclusions: The future development of social capital policies and interventions should focus on not only the promotion of cognitive social capital and social participation among rural community-dwelling older adults, but also the social needs of older rural Chinese adults with low family social capital.
Morpho-anatomical and Phylogenetic studies of Russula species from Narkanda, India
Authors: Kaur Munruchi , Kaur Amandeep , Wani Naseema Aqbar 
Published: November 2022

Abstract
Background
The genus Russula is considered one of the most abundant and widely distributed ectomycorrhizal agaric genera and the Indian subcontinent is no exception to it. The members of this family are cosmopolitan and form an ectomycorrhizal association with a wide range of angiosperm and gymnosperm trees.
Methods and Results
Four new records of genus Russula viz., Russula pauriensis var. caulocystidii var. nov., Russula globispora, Russula cuprea and Russula laeta were collected from Narkanda, Himachal Pardesh, India. These were described and illustrated on the basis of morpho-anatomical characters as well as phylogentic analysis of internal transcribed spacer (ITS) ribosomal DNA sequences. On the basis of gross taxonomic characterization Russula pauriensis var. caulocystidii var. nov. is proposed which is further confirmed through molecular taxonomy. Russula laeta, Russula globispora, Russula cuprea and Russula laeta is reported for the first time from India while Russula amethystina is a rereport.
Conclusion
Current environmental challenges of global warming and climate change will affect the regeneration and growth patterns of delicate fungi that require specific microclimate. Present study is a step towards deciphering macrofungal diversity, especially in the biodiversity-rich forests of Narkanda, to enable diversity planning, management and conservation.
A novel hsa_circ_0006903 promotes tumor development and dendritic cells activated expression in infantile hemangioma
Authors: Gao Xibo , Chen Lixin , Zuo Hailiang , Li Qinfeng 
Published: November 2022

Abstract
Background: Increasing studies revealed that circular RNAs (circRNAs) and immune cell infiltration were associated with tumor development. However, its role in infantile hemangioma (IH) remains unclear. This study will explore a novel circRNA hsa_circ_0006903-based ceRNA network and validate dendritic cells activated expression in IH.
Methods: Differentially expressed circRNAs(DECs) were identified from Gene Expression Omnibus (GEO) database. Regulatory networks and functional enrichment analysis were constructed. CIBERSORT was used to characterize immune cells composition. RT-qPCR was performed to detect the expression of hsa_circ_0006903 in cell lines. Then, the biological functions of hsa_circ_0006903 were validated in vitro using transwell assay. Immunofluorescence was applied to the colocalization of CD11b for dendritic cells activated as a biomarker in IH tissues.
Results: Using GEO database, a total of 67 DECs were identified in IH. Hsa_circ_0006903 was selected as the most significant DECs in this study. Then, a novel hsa_circ_0006903-ceRNA network was constructed. Mechanistically, functional enrichment analysis showed that the p53 signaling pathway played the most important roles, and hsa_circ_0006903/miR-6721-5p/CACNA2D2 and hsa_circ_0006903/miR-4786-3p/ATP13A4 axis were identified. We found that CACNA2D2, ATP13A4, and P53 were significantly downregulated in IH cell lines. In this study, we validated that dendritic cell activated was significantly overexpressed. Moreover, CD11b as a biomarker of dendritic cells activated were tested in IH tissues. Finally, hsa_circ_0006903 was significantly overexpressed, and hsa_circ_0006903 promoted infantile hemangioma cell proliferation, invasion, and migration in vitro.
Conclusion: We revealed a novel hsa_circ_0006903-mediated ceRNA network and explored the landscape of immune cells infiltration, especially CD11b overexpression as a biomarker of dendritic cells activated in IH.
Dietary supplementation with xylooligosaccharides and exogenous enzyme improved milk production, energy utilization efficiency and reduced enteric methane emissions of Jersey cows
Authors: Dong Lifeng , Zhao Lei , Li Bowei , Gao Yanhua , Yan Tianhai , Lund Peter , Liu Zhuofan , Diao Qiyu 
Published: November 2022

Abstract

Background
Sustainable strategies for enteric methane (CH4) mitigation of dairy cows have been extensively explored to improve production performance and alleviate environmental pressure. The present study aimed to investigate the effects of dietary xylooligosaccharides (XOS) and exogenous enzyme (EXE) supplementation on milk production, nutrient digestibility, enteric CH4 emissions, energy utilization efficiency of lactating Jersey dairy cows. Forty-eight lactating cows were randomly assigned to one of 4 treatments with a 2 ×2 factorial arrangement of treatments: (1) control diet (CON), (2) CON with 25 g/d XOS (XOS), (3) CON with 15 g/d EXE (EXE), and (4) CON with 25 g/d XOS and 15 g/d EXE (XOS + EXE). The 60 d experimental period consisted of a 14-d adaptation period and a 46-d sampling period. The enteric CO2 and CH4 emissions and O2 consumption were measured using the GreenFeed system, which were further used to determine the energy utilization efficiency of cows.
Results
Compared with CON, XOS and EXE synergistically (P < 0.05) increased milk yield, fat concentration, and energy-corrected milk yield (ECM)/DM intake, which could be reflected by the significant improvement (P < 0.05) of dietary NDF and NDF digestibility. The gaseous results showed that XOS and EXE synergistically (P < 0.05) reduced CH4 emission and CH4 emissions intensities (e.g., CH4/DM intake, CH4/milk yield, and CH4/ECM yield), whereas CO2 emission and O2 consumption remained similar among the treatments (P > 0.05). Furthermore, the synergistic effects of XOS and EXE was observed (P < 0.05) for metabolizable energy intake and CH4 energy output as a proportion of gross energy intake, whereas lowest values (P < 0.05) of CH4 energy output and CH4 energy output as a proportion of gross energy intake was observed for cows fed XOS compared with the remaining treatments.
Conclusions
Dietary supplementary of XOS and EXE contributed to the improvement of lactation performance, nutrient digestibility, and energy utilization efficiency, as well as reduction of enteric CH4 emissions of lactating Jersey cows. More research is also needed to investigate the long-term effect and mode of action of these additives for Jersey cows.
WITHDRAWN: Integrated Reliability, Resilience and Sustainability Framework for Water Supply Systems Risk Management
Authors: Dweedar Sohaila , Mobasher Amir , Elashry Osama , Reda Mohamed 
Published: November 2022

Abstract
The water supply system (WSS) is usually collected from the water source, transmission pipes, treatment plants and water distribution networks to taps and usually exposed to various risks. However, this study provides a framework for WSS that provides drinkable water to various Cairo regions. The scope of work consisted of two main parts, at the first part, the methodology for risk management in Cairo water system will be adopted by assessment of common risks in water distribution systems (WDS), and these types of risks are classified depended on its effect on the reliability, resilience and sustainability. While, at the second part, Analytic Hierarchy Process (AHP) method is developed to incorporate risk alternatives mitigation based on supply reliability, resilience and sustainability. And therefore supply decision support on the choosing of risk response strategies according to the correspondence between their reference and comparability sequences. The results of this paper showed that several risks represent the main parameter that need to characterize water supply systems and their operations, The application of the frame work mentioned in this study will result in increasing the overall score of Al Amerya Water Treatment Plant (WTP) by 49%; moreover the score of Mostorud WTP will improve by 48%. Additionally, the study provided a base for water utilities to reduce the risk of disobedience and achieve desirable service standards in the short, medium and long term, So Water providers can apply this study framework to assist future evaluation.
Thermal and Dynamic Radiation in the THz range under Spin CurrentInjection in Magnetic Junctions
Authors: Chigarev S. G. , Fomin L. A. , Rai D. P. , Vilkov E. A. , Byshevsky-Konopko O. A. , Zagorsky D. L. , Doludenko I. M. , Panas A. I. 
Published: November 2022

Abstract
An experimental approach to the problem of the energy distribution of radiation in the THz range created by an electron flow passing through a magnetic junction between thermal and dynamic is considered. The experimental results obtained during the operation of a spin-injection emitter based on an array of heterogeneous magnetic nanowires confirmed the assumption about the "competition" of thermal and dynamic radiation processes.
Serum folate and homocysteine levels are associated with cardiometabolic risk factors in patients with type 2 diabetes
Authors: Men Xueyan , Yang Jin , Yan Yelan , Yue Peipei , Zhang Meng , Gong Li , Liu Shengyun 
Published: November 2022

Abstract
Background
Previous studies indicate that serum folate is inversely associated with metabolic syndrome (MetS). This study aims to investigate the association between serum folate, homocysteine (Hcy) levels, and cardiometabolic risk in patients with type 2 diabetes (T2D).
Methods
Associations between serum folate, Hcy levels, and cardiometabolic risk factors were assessed in a cross-sectional study of 755 participants with T2D.
Results
In individuals with MetS, the serum folate levels were significantly lower than in subjects without MetS, whereas the serum Hcy was significantly higher. Serum folate level was negatively correlated with CRP, body mass index (BMI), serum Hcy, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), serum uric acid (UA), and diastolic blood pressure (DBP) but positively correlated with high-density lipoprotein cholesterol (HDL-C). Furthermore, serum Hcy concentrations were positively correlated with BMI, UA, total cholesterol, TG, and LDL-C. A multiple linear regression analysis was used to identify predictors for cardiometabolic risk. Low serum folate levels were identified as an independent risk factor for obesity and dyslipidemia in patients with T2D. Moreover, high serum Hcy levels were positively associated with serum UA and hypertension after adjusting for potential confounders.
Conclusion
Low serum folate levels was an independent risk factor for obesity and dyslipidemia in the T2D population. High Hcy levels were positively associated with serum UA and hypertension.
A New Evaluation Method: Evaluation Data and Metrics for Chinese Grammatical Error Correction
Authors: Lin Nankai , Fu Yingwen , Lin Xiaotian , Yang Ziyu , Jiang Shengyi 
Published: November 2022

Abstract
As a fundamental task in natural language processing (NLP), Chinese Grammatical Error Correction (CGEC) [1–3] has gradually received widespread attention and become a research hotspot. However, one obvious deficiency of the existing CGEC evaluation systems is that the evaluation values of the same error correction models are signif- icantly influenced by the Chinese word segmentation (CWS) results or different language models. However, it is expected that these met- rics should be independent of the CWS results and language models for a fair evaluation. To this end, we propose three novel eval- uation metrics for CGEC in two dimensions: reference-based and reference-less. What’s more, according to these three evaluation met- rics, we build a new evaluation metric that can comprehensively evaluate the CGEC model from multiple dimensions. We deeply eval- uate and analyze the reasonableness and validity of the proposed metrics, and we expect them to become a new standard for CGEC.
Electron Spin Resonance Study of Magnetite Nanoparticles as a Magnetically Separated Catalyst for Epoxide Thiolysis
Authors: Yakushkin S. S. , Kirillov V. L. , Philippov A. A. , Martyanov O. N. 
Published: November 2022

Abstract
Catalytic systems based on the colloidal magnetite Fe3O4 nanoparticles were studied in the epoxide thiolysis reaction conditions and during the magnetic separation. Two samples of superparamagnetic Fe3O4 nanoparticles with the mean size of 4 nm and 10 nm were studied using electron paramagnetic resonance in situ, X-ray diffraction and electron microscopy. The role of the nanoparticles size for the magnetic separation effectiveness and catalytic effect in the epoxide thiolysis reaction has been demonstrated.
Low-Cost Defect Simulation Framework for Analog and Mixed Signal (AMS) Circuits with Enhanced Time-Efficiency
Authors: Saikiran Marampally , Sekyere Michael , Ganji Mona , Yang Ruohan , Chen Degang 
Published: November 2022

Abstract
Defect-oriented testing is becoming increasingly popular in recent times, especially in safety-critical applications in automotive, space and medical industries. The stringent quality requirements from these industries such as zero defective parts per million (DPPM) necessities a need to have efficient defect testing methods. Furthermore, the overall development time of integrated circuit can be reduced by reducing the defect simulation time. In this work, we present a simple and time-efficient defect simulation framework for pre-silicon testing of AMS circuits. In our method, a given defect model is realized using Verilog-A modules and tests multiple defects in a circuit in a single-run simulation. In contrast to the conventional defect simulation framework, our method saves simulation time by avoiding the repetitive work of generating a netlist for each defect and by reducing the time overhead for the simulator to interface with data/file-handling system. To strongly validate our proposed framework, we use diverse AMS circuits such as operational amplifier (op amp), fast transient flipped-voltage follower based low-dropout regulator (FVF LDO) and Successive-approximation-register (SAR) analog-to-digital converters (ADC). For DC testing schemes used for op amp and LDO testing, we show that our proposed framework reduces the simulation time to less than one-tenth (1/10th) in comparison with conventional framework. On the other hand, for the transient testing scheme, the proposed framework reduces the simulation time to less than 50% of the conventional framework. Furthermore, we also show that there is no negative impact on the defect coverage using the proposed framework.
Uniquely trigger the death of cancer cells by destruction of lysosomes
Authors: Du Ying-Ying , wang ying-pu , Xing En-Yun , Yin Juan-Juan , Jiang Xu , Wang Ning , Lin Yan-Xin , Shi Rui-Jie , Wang Ping , Xiao Xiang-Qian , Feng Ya-Qing , Meng Shu-Xian 
Published: November 2022

Abstract
In recent years, various anti-tumor treatment methods have emerged in endlessly. Here in, a novel anti-tumor mechanism is designed and a special double-layer nanoparticles (CMC/MgO @ FA-CS/BODIPY NPs) were prepared. It utilizes the special acidic environment of cell lysosomes to swell violently in lysosomes, destroy lysosomes and release hydrolases. Because the number of tumor cell lysosomes is significantly more than that of normal cells, and the volume is also larger, resulting in the release of a large number of hydrolases to digest the entire tumor cell and cause it to die, while the number of normal cell lysosomes is small, and the destruction of lysosomes is not enough to kill cell. In this paper, animal experiments and the control experiments of tumor cells and normal cells prove that the designed nanoparticles have a broad-spectrum antineoplastic activities and are harmless to normal cells. At the same time, the nanoparticles are mainly composed of carboxymethyl cellulose (CMC), chitosan (CS) and other commonly used pharmaceutical excipients, which have no toxicity. Therefore, this method is a new safe and effective way to treat tumors. It has not been reported in any literature.
Nursing undergraduates’ perception towards the flipped classroom of Operating Room Nursing Operation based on the HTML5 mobile micro-class: A qualitative study
Authors: Wu Fei , Chen Jie , Huang Xi , Mo Wenjuan , Hu Li , Li Xiaohan , Liao Li 
Published: November 2022

Abstract
Background: The flipped classroom (FC) is a blended teaching method based on digital resources. The traditional FC in the field of nursing practice teaching that relies on video micro-class to achieve the goal of flipped teaching has been confirmed effective. However, the video micro-class has few interactions with students,while the HTML5 mobile micro-class is theoretically more diverse and more interactive.For the time being, this statement lacks robust evidence from nursing undergraduates’ perception towards the FC of Operating Room Nursing Operation (ORNO) based on HTML5 mobile micro-class.
Purpose: To provide a basic reference for nursing educators to carry out flipped classroom in practical teaching, we deeply comprehend nursing undergraduates’ perception towards the ORNO-FC based on the HTML5 mobile micro-class.
Methods: An qualitative descriptive research method using semi-structured interviews were conducted among 17 students who participated in the ORNO-FC based on the HTML5 mobile micro-class by purposive sampling. Thematic analysis was conducted to analyze the data in order to identify themes in the interview transcripts.
Results: Analysis of the interview content revealed four primary themes along with sub-themes: (1) improvement in the learning state, (2) enhancement in the learning effect, (3) insufficiency of mobile micro-class production, and (4) insufficiency of teaching design.
Conclusion: Through the ORNO-FC based on HTML5 mobile micro-class can give back learning autonomy to students so that they can meet their own demands with personal style, boost the learning efficiency of students, inspire their interest in learning, improve their health physically and mentally, and significantly make the teaching atmosphere student-centered. However, the FC of practical teaching is not suitable for all operational projects; therefore, mobile micro-class should be combined with demonstrations by teachers for highly complex projects with many operational details and high degree of complexity.