bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antifungal activity and genomic characterization of the biocontrol agent Bacillus velezensis CMRP 4489
Authors: Baptista Julia Pezarini , Teixeira Gustavo Manoel , de Jesus Maria Luiza Abreu , Bertê Rosiana , Higashi Allan , Mosela Mirela , da Silva Daniel Vieira , de Oliveira João Paulo , Sanches Danilo Sipoli , Brancher Jacques Duílio , Balbi-Peña Maria Isabel , de Padua Pereira Ulisses , de Oliveira Admilton Gonçalves 
Published: October 2022

AbstractThe development of bio-based products has increased in recent years, and species of theBacillusgenus have been widely used for product development due to their elevated production of antimicrobial molecules and resistance to extreme environmental conditions through endospore formation. In this context, the antifungal potential ofBacillus velezensisCMRP 4489 was investigated using in silico predictions of secondary metabolites in its genome and in vitro tests against the following phytopathogenic fungi:Sclerotinia sclerotiorum,Macrophomina phaseolina, andBotrytis cinerea. The in-silico predictions indicated that CMRP 4489 possesses several Biosynthetic Gene Clusters (BGCs) capable of producing molecules with antifungal properties and other non-identified BGCs. The in vitro assay results evidenced strong antifungal activity, inhibiting more than 60% of the tested fungi, and the isolate’s molecules were stable under diverse physicochemical conditions. The in vitro assay evidenced significant antifungal activity, deformation of the hyphal structure in SS, biofilm formation capacity, and swarming motility. In the colonization assay, we observed attachment, colonization, and net-shaped biofilm formation, with the strain transitioning from the seeds to nearby structures. Therefore, CMRP 4489 showed to be a potential biocontrol agent against various diseases with agronomic importance and can be used under adverse environmental conditions.
Research on lung nodule recognition algorithm based on deep feature fusion and MKL-SVM-IPSO
Authors: Li Yang , Zheng Hewei , Huang Xiaoyu , Chang Jiayue , Hou Debiao , Lu Huimin 
Published: October 2022

AbstractLung CAD system can provide auxiliary third-party opinions for doctors, improve the accuracy of lung nodule recognition. The selection and fusion of nodule features and the advancement of recognition algorithms are crucial improving lung CAD systems. Based on the HDL model, this paper mainly focuses on the three key algorithms of feature extraction, feature fusion and nodule recognition of lung CAD system. First, CBAM is embedded into VGG16 and VGG19, and feature extraction models AE-VGG16 and AE-VGG19 are constructed, so that the network can pay more attention to the key feature information in nodule description. Then, feature dimensionality reduction based on PCA and feature fusion based on CCA are sequentially performed on the extracted depth features to obtain low-dimensional fusion features. Finally, the fusion features are input into the proposed MKL-SVM-IPSO model based on the improved Particle Swarm Optimization algorithm to speed up the training speed, get the global optimal parameter group. The public dataset LUNA16 was selected for the experiment. The results show that the accuracy of lung nodule recognition of the proposed lung CAD system can reach 99.56%, and the sensitivity and F1-score can reach 99.3% and 0.9965, respectively, which can reduce the possibility of false detection and missed detection of nodules.
Spatial assortment of soil organisms supports the size-plasticity hypothesis
Authors: Isabwe Alain , Yao Haifeng , Zhang Shixiu , Jiang Yuji , Breed Martin F , Sun Xin 
Published: October 2022

Abstract
The size-plasticity hypothesis posits that larger size organisms are less plastic in their metabolic rates and, therefore, are more strongly environmental-filtered than smaller organisms. Many studies have supported this hypothesis by evaluating the relative roles of environmental filtration and dispersal for different taxonomic groups of soil organisms. Most observations are made at large spatial scales, which are assumed to have a wide array of varying habitats. However, since urbanization causes habitat fragmentation at smaller regional scales, testing the size-plasticity hypothesis at this scale would help better understand the spatial assortment of urban soil organisms which, in turn, would help to develop improved management and conservation strategies for urban soil health. Here, we used DNA metabarcoding on five groups of soil biota (bacteria, fungi, protists, nematodes, and invertebrates) to assess the relative importance of dispersal and environmental filters to examine the size-plasticity hypothesis at this spatial scale in an urban environment. We observed strong distance-decay of community similarities associated with higher levels of stochastic changes in bacteria, nematode, and protist communities but not fungal or invertebrate communities. Bacterial communities occupied the widest niche followed by protists and nematodes, potentially because of their higher dispersal abilities compared to the larger soil organisms. Null deviation of communities varied with taxonomic groups where bacteria and nematodes were mainly driven by homogenizing dispersal, protists and fungi by drift, and soil invertebrates by environmental selection. We further identified a small percentage of locally-adapted taxa (2.1%) that could be focal taxa for conservation and restoration efforts by, for example, restoring their habitats and enhancing their regional connectivity. These results support the size-plasticity hypothesis at the relatively unexplored regional scale in an urbanization context, and provide new information for improving urban soil health and sustainable city models.
Single-detector 3D optoacoustic tomography via coded spatial acoustic modulation
Authors: Hahamovich Evgeny , Monin Sagi , Levi Ahiad , Hazan Yoav , Rosenthal Amir 
Published: October 2022

AbstractOptoacoustic tomography (OAT) is a hybrid imaging modality that combines optical excitation with ultrasound detection and enables high-resolution visualization of optical contrasts at tissue depths in which light is completely diffused. Despite its promise in numerous research and clinical applications, OAT is limited by the technological immaturity of ultrasound detection systems. It suffers from limited element count, narrow field of view and lack of technology for spatial modulation of acoustic signals. Here we report single-detector OAT capable of high-fidelity imaging using an amplitude mask in planar geometry coded with cyclic patterns for structured spatial acoustic modulation. Our image reconstruction method maximises sensitivity, is compatible with planar signal detection, and uses only linear operations, thus avoiding artefacts associated with the nonlinear compressed-sensing inversion. We demonstrate our method for 3D OAT of complex objects and living tissue performed with only a single ultrasound detector, effectively coded into a 2D array with 1763 elements. Our method paves the way for a new generation of high-fidelity, low-cost OAT systems.
Emotional Sentence Processing in Parkinson's Disease
Authors: Hazamy Audrey A. , Altmann Lori J. P. 
Published: October 2022

Purpose:
Emotional processing allows us to predict our own and others' behavior, communicate our wants and needs, and understand those of others. Thus, deficits in emotional processing can negatively impact one's quality of life. While changes in emotional processing across several domains (e.g., prosody, faces) in Parkinson's disease (PD) are widely accepted, there is a dearth of literature, with equivocal results, regarding how emotional language processing is affected by PD. This study investigated emotional sentence processing in this population.

Method:
Eighteen persons with PD and 22 healthy adults (HAs) completed a language task in which they rated sentences on their pleasantness (valence), and a battery of cognitive tasks and mood measures that were examined as factors influencing performance. As an interaction between emotionality and concreteness during processing has been indicated in prior research, concreteness of sentence stimuli was also manipulated.

Results:
Individuals with PD rated negatively valenced sentences as less negative and positively-valenced sentences as less positive than HAs. The PD group also demonstrated a reduced overall range of valence rating scores. Sentence concreteness did not influence ratings. Results for positive sentences could be explained by individual differences in working memory (WM), whereas individual differences in WM, depression, and group explained differences in ratings to negative sentences.

Conclusions:
Our study provides one of few accounts of emotional language processing deficits in PD, particularly beyond the word level. Individuals with PD may experience difficulty perceiving and assessing the intensity of the emotional content of language, and deficits may disproportionately impact processing of sentences about negative situations.

Supplemental Material:

https://doi.org/10.23641/asha.21313713
Asynchronous cooperative spectrum sensing via sequential detection in fuzzy hypothesis testing under noise uncertainty in cognitive radio networks
Authors: Xie Shujing 
Published: October 2022

AbstractSpectrum sensing is a critical part in Cognitive radio networks to detect the available frequency resources, and its timeliness and accuracy are extremely important. The conventional detectors usually fail to be robust in the presence of noise uncertainty, hence an asynchronous cooperative spectrum sensing approach based on sequential probability ratio detection in fuzzy hypothesis testing is proposed. In the approach, sequential detection in fuzzy hypothesis testing is done by each cognitive radio to form local decisions, then fusion centre sequentially accumulates the local decisions of cooperative cognitive radios to make a global decision. Simulation results show that the proposed approach can reduce the average number of samples and overcome noise uncertainty when compared with conventional or selective asynchronous cooperative sensing and non‐cooperative sensing.
Characteristics of flares on giant stars
Authors: Oláh K. , Seli B. , Kővári Zs. , Kriskovics L. , Vida K. 
Published: October 2022

Context. Although late-type dwarfs and giant stars are substantially different, their flares are thought to originate in similar physical processes and differ only by a scale factor in the energy levels. We study the validity of this approach.
Aims. We search for characteristics of flares on active giants, which might be statistically different from those on main-sequence stars.
Methods. We used nearly 4000 flares of 61 giants and 20 stars of other types that were observed with Kepler in long-cadence mode, which is the only suitable database for this comparative study. For every flare, we derived the duration and energy and gathered stellar parameters. Correlations between the flare characteristics and various stellar parameters were investigated.
Results. Strong correlations are found between the flare duration and the surface gravity, luminosity, and radii of the stars. Scaled flare shapes appear to be similar on giants and dwarfs with a 30 min cadence. The logarithmic relation of flare energy and duration is steeper for stars with lower surface gravity. Observed flares are longer and more energetic on giants than on dwarfs on average.
Conclusions. The generalized linear scaling for the logarithmic relation of flare energy and duration with a universal theoretical slope of ≈1/3 should slightly be modified by introducing a dependence on surface gravity.
Exploring the genesis of spiral galaxies
Authors: Breda Iris , Papaderos Polychronis 
Published: October 2022

Context. A tantalizing enigma in extragalactic astronomy concerns the chronology and driving mechanisms of the build-up of late-type galaxies (LTGs). The standard scenario envisages two formation routes, with classical bulges (CBs) assembling first in a quick and violent quasi-monolithic episode followed by gradual disk assembly, and pseudo-bulges (PBs) progressively forming over gigayear-long timescales through gentle gas inflow from the disk and in situ star formation. The expectation from this antagonistic rationale is the segregation of present-day LTG bulges into two evolutionary distinct groups, which is in sharp contrast with recent observations.
Aims. The present study aims for a thorough investigation of the star formation history (SFH) of LTGs with its ultimate goal being to outline a coherent framework for the formation and evolution of spiral galaxies and their main stellar components.
Methods. Using population spectral synthesis models, we analyse the spatially resolved SFH of bulges and disks of 135 LTGs from the CALIFA survey, covering the relevant range in LTG mass. Complementarily, characteristic physical properties of bulges and disks, such as mean colours, mass- and light-weighted stellar age and metallicity, and EW(Hα), were contrasted with predictions from evolutionary synthesis models, by adopting exponentially declining SFHs with e-folding times τ between 0.1 and 20 Gyr.
Results. Analysis of the SFH of roughly half a million spaxels consistently reveals that the main physical and evolutionary properties of both bulges and disks are continuously distributed across present-day total stellar mass ℳ⋆, T. The τ in spiral galaxies with log(ℳ⋆, T) > 10 increases from the centre to the periphery, suggesting that these systems grow in an inside-out fashion. Quite importantly, the radial gradient of τ in an individual galaxy increases with increasing ℳ⋆, T, which is consistent with a high bulge-to-disk age contrast in high-mass spirals, while lower-mass LTGs display roughly the same τ throughout their entire radial extent, with intermediate mass galaxies in between. Predictions obtained through evolutionary synthesis are overall consistent with observed properties. Finally, bulges and disks of higher mass galaxies exhibit shorter formation timescales as compared to their lower mass counterparts.
Conclusions. Collectively, the obtained results evince a coherent and unified picture for the formation and evolution of LTGs, in which PBs and CBs denote extremities of a continuous mass sequence. Our findings are consistent with the framework where bulges are assembled jointly with their parent disks by gradual inside-out growth, at a pace that is regulated by the depth of the galactic potential. This postulate is further supported by the fact that the revealed correlations are entirely devoid of a bimodality, as it would be expected if CBs and PBs were to emerge from two distinct formation routes.
Advanced Glycation End Products, Bone Health, and Diabetes
Mellitus
Authors: Jiang Jingjing , Zhao Changyu , Han Tingting , Shan Hongyan , Cui Guiyou , Li Songnan , Xie Zhongwen , Wang Jun 
Published: October 2022

AbstractAdvanced glycation end products (AGEs), the compounds resulting from the
non-enzymatic glycosylation between reducing sugars and proteins, are derived
from food or produced de novo. Over time, more and more endogenous and
exogenous AGEs accumulate in various organs such as the liver, kidneys, muscle,
and bone, threatening human health. Among these organs, bone is most widely
reported. AGEs accumulating in bone reduce bone strength by participating in
bone structure formation and breaking bone homeostasis by binding their
receptors to alter the proliferation, differentiation, and apoptosis of cells
involved in bone remodeling. In this review, we summarize the research about the
effects of AGEs on bone health and highlight their associations with bone health
in diabetes patients to provide some clues toward the discovery of new treatment
and prevention strategies for bone-related diseases caused by AGEs.
Questions to consider when caring for patients with ulcerative colitis
Authors: Hasselblatt Peter , Reindl Wolfgang , Gauss Annika , Neeff Hannes , Fusco Stefano , Klaus Jochen 
Published: October 2022

AbstractAlthough the management of patients with ulcerative colitis (UC) is well defined by national and international guidelines, there are many debates and open questions related to daily care of UC patients. Here, we aimed to review topics with high clinical relevance including therapy algorithms, potential biomarkers for disease prognosis and response to therapy, the role of interventions targeting the gut microbiota, insights from head-to-head trials, novel UC medications, exit strategies, the impact of COVID19 on UC, care of patients with acute severe disease, cancer screening, and the role of surgery.
Safety and Efficacy of Rotational Thrombectomy for Treatment of Arterial Occlusions of the Lower Extremities: A Large Single-Center Retrospective Study
Authors: Artzner Christoph , Martin Isabelle , Hefferman Gerald , Artzner Kerstin , Lescan Mario , de Graaf Rick , Grözinger Gerd 
Published: October 2022

Purpose To evaluate the safety and efficacy of rotational thrombectomy (RT) in a large single-center real-world cohort for total vascular occlusions of the lower extremity.
Materials and Methods The clinical records and images of all patients between 2010 and 2020 treated via RT (Rotarex, BD) were assessed. Patient demographics, clinical data, procedural characteristics, and outcome parameters were documented. In total, 397 procedures in 293 patients were included (mean age 69.8 ± 12.0 years; 64.8 % male). Occlusions were acute (47.5 %), subacute and acute-on-chronic (22.2 %), and chronic (30.3 %). The target lesions were the iliac artery (7.1 %), iliac/femoropopliteal (5.0 %), femoropopliteal (59.4 %), femoropopliteal/below-the-knee (27.0 %), below-the-knee (1.5 %), and after bypass surgery (14.9 %). Lesion length was > 20 cm in 61.5 % of cases.
Results Clinically successful revascularization was achieved in 90.4 % of cases. Additional thrombolysis was necessary for 32.0 % of procedures. The arithmetic mean ankle-brachial index increased from 0.33 ± 0.29 to 0.81 ± 0.25 (p < 0.0001). Bypass grafts were less likely to be fully treatable and required additional lysis (p < 0.001). The overall primary patency (no clinically driven target lesion revascularization) was 93.2 %, 88.8 %, 79.1 %, and 72.4 % at 1, 3, 6, and 12 months, respectively. Adverse events occurred in 46.1 % of cases, of which peripheral embolization (22.4 %) was most frequent, requiring interventional treatment in 67.4 % of cases. RT was directly associated with 7.1 % (n = 28) of complications, which consisted of perforations 2.8 %, arteriovenous fistula 1.3 %, and dissections 2.0 %.
Conclusion Rotational thrombectomy is a safe and efficient method for the treatment of occlusions of the arterial circulation of the lower extremity with bypass occlusions having a higher propensity for residual thrombi requiring further lysis therapy.
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Citation Format
The Multiple V-Y Advancement Modification for the Surgical Correction of Cryptotia
Authors: Duc Nguyen Quang , Tien Nguyen Phuong 
Published: October 2022

AbstractCryptotia is a rare congenital auricular deformity among Caucasians but more common in Asians. Various operative techniques have been described, such as skin graft, V-Y plasty, Z plasty, and islands skin flap. Among those techniques, V-Y plasty has many advantages and is indicated for severe cases. However, several problems remain when this method is adopted, such as conspicuous scars and lowered hairline. To overcome these problems, the authors have developed a new technique, multiple V-Y advancement modification, which stitches the skin flaps together to a tight, discrete central focal point. This technique has the advantage of hiding scars behind the earlobe, providing enough skin for the deformed areas, minimizing the condition of the hairline being lowered and auriculocephalic sulcus depth.
The Deep Fascia of the Infraorbital Region, Deep Plane, and Suprafibromuscular Facelift: New Anatomy for Safer Facelifting
Authors: Andretto Amodeo Chiara , Eggerstedt Michael , Kim Irene A. , Nabili Vishad , Keller Gregory S. 
Published: October 2022

AbstractDeep-plane rhytidectomy, first described by Skoog, has had a resurgence in popularity and is in high demand today. We describe anatomical findings that establish the presence of a true deep fascia in the midface, we named as Chiara's fascia, like the first author's first name, which helps to form the facial ligaments and is contiguous with the superficial layer of the deep temporal fascia. This fascia inserts on the periosteum of the inferior orbital rim at the arcus marginalis and separates the suborbicularis oculi fat (SOOF) from the preperiosteal fat. This distinct fascial layer lies under the superficial fascia or superficial musculoaponeurotic system (SMAS) and represents the floor of what is commonly termed the “deep plane.” When this fascial highway is identified intraoperatively, blunt dissection immediately superficial to this layer will protect facial nerve branches overlying the muscles lifting the upper lip such as the zygomaticus. Subsequent dissection over the middle and lower face can usually be performed bluntly. Over a 10-year period, a total of 100 hemifaces were dissected with a 100% success rate of identifying this fascia in all specimens. This work was further validated by examining histologic specimens that clearly demonstrate this unique fibrofatty fascial layer. These dissections and new anatomical findings were then correlated to over 300 intraoperative deep-plane facelift cases by the primary and senior authors. We term this operative technique as the suprafibromuscular facelift. Dissection in this plane allows for safe release of facial retaining ligaments with protection of facial nerve branches.
Prevalence of Maternal Cytomegalovirus Antibodies and Neonatal Congenital Cytomegalovirus at Less than 34 Weeks of Gestation: A Prospective Study
Authors: Kalane Shilpa U. , Raste Lavannya , Patwardhan Sampada , Beasley Digna A. , Devaskar Uday P. 
Published: October 2022

Objective Congenital cytomegalovirus (cCMV) acquired postnatally can lead to hearing loss and adverse central nervous system (CNS) function, especially in the preterm neonate. We prospectively determined the prevalence of maternal serum CMV-immunoglobulin (IgG) and the incidence of cCMV at <34 weeks of gestation.
Study Design Study was conducted in the United States and India. Maternal blood was collected within 5 days after delivery. CMV-IgG antibodies were quantitated by an immunoassay. Baby's urine at birth was tested for CMV-DNA by the polymerase chain reaction.
Results In total, 65 women and 74 neonates were studied. In the United States, 6 out of 21 (76%), while in India, 42 out of 44 (96%) mothers were seropositive (combined 89%). In the United States, none of the neonates had CMV in the urine, while in India 4 out of 52 (7.7%) were positive (combined 5.4%)
Conclusion Mother's blood and baby's urine should be tested for serum CMV-IgG antibodies and CMV-DNA at delivery at <34-weeks of gestational age. Targeted screening will help in making an early diagnosis of cCMV, initiate therapy, and detect and treat early CNS problems including hearing loss.
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