bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of electro-press needle for menopause-associated hot flashes
Authors: Yu Shudan , He Xin , Shi Hangyu , Chen Yu , Liu Zhishun 
Published: February 2022

Abstract

Background:
Hot flashes (HF) are a prevalent symptom associated with menopause affecting up to 85% of women aged 40 to 65 years. Previous studies indicated that acupuncture might relieve the symptom of HF significantly; however, its effectiveness has not been clarified quantitatively. Electro-press needles (EPN) is a novel acupuncture that combines a shallow tiny needle with an electrical transdermal stimulator. Either the needle or the electrical stimulator could function in the treatment. This study aims to evaluate the effectiveness of EPN in comparison with no intervention in relieving HF of perimenopausal and postmenopausal women.

Methods/Design:
This study will be a 2-arm randomized waitlist controlled trial. According to the ratio of 1:1 and block randomization, a total of 122 patients with moderate or severe HF will be randomly allocated to either EPN group or waitlist control group. The EPN group will receive 3 sessions of EPN treatment each week in consecutive 6 weeks, 18 sessions in total. The waitlist control group will get no intervention over the first 6 weeks. All the patients will be followed up in the next 24 weeks. The primary outcome will be the percentage of the participants whose 24-hour mean HF is 50% less than the baseline at Week 6. Secondary outcomes will include HF score, HF frequency, HF severity, the Menopause Rating Scale and Menopause-Specific Quality of Life Questionnaire Score.

Discussion:
This study will evaluate the effectiveness and safety of EPN treatment to alleviate HF symptoms in perimenopausal and postmenopausal women, excluding self-healing factors. The limitations of the trial design are its single-center scope, lack of placebo control and impossible to blind the acupuncturists and patients.

Trial registration: This clinical trial has been registered in Clinical Trial Registry (registration number: NCT04995107; date of registration: Aug 6, 2021).
Comprehensive traditional East Asian medicine treatment strategy for obesity considering the therapeutic effects and adverse events
Authors: Chu Hongmin , Kang Byungsoo , Youn Bo-Young , Kim Kwan-il , Park Jinbong , Leem Jungtae 
Published: February 2022

AbstractBackground:Obesity has become a serious global health problem due to its increasing prevalence. Because of several limitations or adverse events associated with conventional western medicine therapies, there has been an increase in demand for alternative therapies such as traditional East Asian medicine (TEAM). This study aims to provide comprehensive evidence-based information assessing the clinical efficacy and safety of TEAM treatment for obesity as the basis for reliable clinical strategies for patients with obesity.Methods:Electronic searches of the PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure, OASIS, and Korea Citation Index will be performed. Methodological quality will be assessed using the “risk of bias” tool. The primary outcome for efficacy will be weight loss. The secondary outcomes will be response rate, body mass index, waist circumference, and blood pressure. We will also evaluate the rates of adverse events and mortality for safety assessment. First, we will conduct a conventional pairwise meta-analysis. Next, we will conduct network meta-analysis using the frequentist approach. We shall verify the assumption of network meta-analysis and provide network geometry, P-score, net league table, and intervention-based forest plot. A subgroup analysis will be conducted to ascertain the factors that affect treatment, such as dosage, treatment duration, and severity of obesity.Results:The results of this study will provide high-quality systematic reviews that can assist decision making in obesity management. Our network meta-analysis results can provide direct and indirect comparison evidence on comparative efficacy and safety.Conclusion:This study will provide fundamental data for prospective research on the application of TEAM in patients with obesity.Protocol registry number of online registry:This study protocol was registered in open Science framework (OSF) (Registration DOI: 10.17605/OSF.IO/ETWDS)URL of the online registry:https://osf.io/etwds.
Acupuncture and massage combined with rehabilitation therapy for hemiplegia after stroke
Authors: Liu Chang , Pang Tingting , Yao Junjie , Li Jiahui , Lei Siyuan , Zhang Jiangchun , Wang Yufeng , Bian Jing 
Published: February 2022

Abstract

Background:
The purpose of this study was to evaluate the effectiveness and safety of acupuncture and massage combined with rehabilitation in the treatment of hemiplegia after stroke.

Methods:
To collect relevant literature, we will research following databases: Medicine, PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wan-Fang Database, Chongqing VIP Chinese Science and Technology Periodicaols Database, and China Biomedical Database; the time is from its creation to May 2021, and the language is limited to Chinese and English. In addition, we will retrieve other literature resources, including the Chinese Clinical Trial Register and conference articles. Two reviewers will independently complete the literature screen and data extraction and quality assessment of the included studies will be independently completed by two other researchers. The primary outcomes included the Modified Ashworth scale and the simplified Fugl-Meyer Assessment scale. The Modified Barthel Index, the China Stroke Scale, and adverse reactions as secondary outcomes were assessed. RevMan V.5.4.1 software will be used for meta-analysis, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) will be used to assess the quality of evidence.

Results:
This systematic review will provide a high-quality synthesis to evaluate the efficacy and safety of acupuncture and massage combined with rehabilitation in the treatment of hemiplegia after stroke, providing a reference for the safe and effective treatment of hemiplegia after stroke.

Conclusion:
This study provides evidence that acupuncture and massage combined with rehabilitation therapy is effective.

Ethics and dissemination:
The protocol of the systematic review does not require ethical approval because it does not involve humans. This article will be published in peer-reviewed journals and presented at relevant conferences.

Systematic review registration:
INPLASY202210026.
Ossifying pilomatricoma and a novel hypothesis for its pathogenesis
Authors: Sung Kun-Yong , Lee Seungkoo , Jeong Yeonjin , Lee Sang-Yeul 
Published: February 2022

Abstract

Rationale:
Pilomatricoma is a benign skin appendageal tumor derived from hair follicle matrix cells that commonly affects the head, neck, and upper extremities of the pediatric population. Since the original tumor description, diverse variants have been reported in the literature. Pilomatricoma with florid osseous metaplasia is described as an ossifying pilomatricoma and is recognized as a distinct variant of this benign tumor. However, the pathogenesis of this variant remains unclear. In this study, we present an uncommon case of ossifying pilomatricoma and address the pathogenesis of metaplastic ossification through a comprehensive literature review.

Patient concerns:
A 14-year-old boy presented with an asymptomatic protuberant mass in the preauricular region.

Diagnosis:
Based on its clinicopathological features, we diagnosed the lesion as an ossifying pilomatricoma.

Interventions and outcomes:
The lesion was surgically removed under local anesthesia. The postoperative course was uneventful during the 6-month postoperative follow-up.

Lessons:
We suggest that metaplastic ossification in ossifying pilomatricoma represents another feature of foreign body reaction to keratinous materials containing shadow cells in old lesions and a walling-off phenomenon to prevent exposure of surrounding tissues to keratinous materials.
The effects of intravascular photobiomodulation on sleep disturbance caused by Guillain-Barré syndrome after Astrazeneca vaccine inoculation
Authors: Chang Yuan-Ling , Chang Shin-Tsu 
Published: February 2022

Abstract

Rationale:
Sleep disturbance is commonly noted after Guillain-Barré syndrome (GBS) and is often caused by persistent discomfort after disease survival. Intravascular laser irradiation of blood (ILIB) has been shown to be effective in pain modulation owing to the influence of nociceptive signals in the peripheral nervous system. We investigated the application of ILIB on post-Oxford –AstraZeneca vaccination GBS and evaluated its effect on sleep quality.

Patient concerns:
A 48-year-old woman was subsequently diagnosed with GBS after Oxford–AstraZeneca vaccination. The patient was discharged after a 5-day course of intravenous immunoglobulin administration. However, 1 week after discharge, the previously relieved symptoms flared with accompanying sleep disturbance.

Diagnosis and interventions:
The patient was diagnosed with post-vaccination GBS, and persistent pain and sleep disturbances persisted after disease survival. ILIB was performed.

Outcomes:
We used the Pittsburgh Sleep Quality Index before and after intravascular laser irradiation. There was a marked improvement in the sleep duration, efficiency, and overall sleep quality. The initial score was 12 out of 21 and the final score was 7 out of 21.

Lessons:
We found that ILIB was effective in pain modulation in post-vaccination GBS and significantly improved sleep quality.
Tuina combined with physical therapy for spasticity of poststroke
Authors: Ji Yuanyuan , Wang Yufeng , Lou Huijuan , Zhang Yuxin , Liu Yangshengjie , Zheng Xu , Jia Xiushuang , Yang Kang , Zhang Hongshi , Cong Deyu 
Published: February 2022

Abstract

Background:
Limb spasms are a common complication of stroke. It not only affects the quality of life of stroke survivors, but also brings an economic burden. Tuina combined with physical therapy is widely used in the rehabilitation of poststroke spasticity. However, there is no supporting evidence for its efficacy and safety. This study aimed to evaluate the effectiveness and safety of Tuinas combined with physical therapy in the treatment of spasticity after stroke.

Methods:
Literature will be collected from the following databases: China Biology Medicine (CBM), Wanfang Database, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), PubMed, Embase, Cochrane Library, and Web of Science; We will include randomized controlled trials of Tuina combined with physical therapy for poststroke spasticity range from the establishment to May 1, 2021. There were no limitations to the publication time, and the language was limited to Chinese and English. The primary outcome was evaluated using the Modified Ashworth scale, and the secondary outcomes were the simplified Fugl-Meyer Assessment scale, Modified Barthel Index, Functional Independence Measurement (FIM), and Visual Analog Scale. RevMan V.5.4.1 software was used for the meta-analysis. The Cochrane Intervention System Evaluation Manual analyzes the risk of bias, and the recommended grading assessment, development and evaluation are used to assess the quality of evidence.

Ethics and dissemination:
This study will be based on published systematic review studies, no ethical approval is required and the results of the study will be published in a peer-reviewed scientific journal.

Systematic review registration:
INPLASY2021110064.
Redesigning doctor–patient relationship in the private health care during COVID-19 pandemic
Authors: Bertozzi Serena , Taricani Roberta , Tulissi Irene , Patusso Fabio , Amura Stefano , Londero Ambrogio P. 
Published: February 2022

Abstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is experiencing pandemic diffusion. The experience of an Italian private health care structure was reviewed.
We retrospectively collected data about services provided in a single medium complexity private health care structure. Furthermore, we classified specialties within 4 categories, based on the performance of urgent non-deferrable services and possible provision of services without a necessary contact with the patient.
The structure canceled/postponed almost every deferrable service, providing only 3% of services that could be performed without direct contact with patients. Regarding non-deferrable services requiring the presence of the patient, about 42% of booked services have been autonomously canceled/postponed by patients for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) fear. The administrative services have been remotely performed by smart working as far as possible.
Private health care structures may safely continue to provide non-deferrable services while respecting the restrictive measures imposed by the government, encouraging telehealth and smart working modalities.
Childhood neuroendocrine tumors of the digestive system
Authors: Kartal İbrahim 
Published: February 2022

Abstract
The prevalence and incidence of neuroendocrine tumors (NETs) are increasing in the pediatric population. This increase can be associated with improved diagnostics and increased detection rates of the disease. We aimed to discuss the clinical and pathological characteristics of patients with this rare disease who were followed and treated at our center.
The medical records of children (aged 0–18 years) with NETs of the digestive system, followed up and treated between 2007 and 2020 at Ondokuz Mayis University Faculty of Medicine, were reviewed.
Overall, 16 patients (8 girls and 8 boys) were analyzed. Fifteen patients had NETs in the appendix; 14 of these had grade I NETs, and 1 had grade II NETs. No additional surgery was performed except for appendectomy. All patients were in complete remission at the last follow-up (median 38 months). The other patient, a 12-year-old girl, had a primary hepatic neuroendocrine carcinoma (grade III NET). Three cycles of neoadjuvant and adjuvant platinum-based chemotherapy were administered, and right hepatectomy was performed to remove the mass. The patient is being followed-up for approximately 3 years without disease recurrence.
Most NETs are observed in adults, and most studies have focused on this population. Unlike adults, increasing awareness of the disease in the pediatric population (especially in cases of acute appendicitis), discovering therapeutic treatments, and sharing experiences are crucial for developing an optimal therapeutic approach for pediatric NETs.
Cholangitis in patients with atrial fibrillation
Authors: Hu Wei-Syun , Lin Cheng-Li 
Published: February 2022

Abstract
The purpose of this study is to investigate whether atrial fibrillation (AF) and cholangitis is associated.
This is a propensity-matched retrospective cohort report from the Taiwan National Health Insurance Research Database. We included patients who had AF but didn’t have cholangitis, and matched controls between January 1, 2000 and December 31, 2012. The AF cohort comprised 114,572 patients and the comparison cohort comprised 114,572 subjects. All participants were followed up until developing cholangitis, death, or December 31, 2013, whichever came first. The cox model was used to calculate the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for comparing the risk of cholangitis in the AF cohort and non-AF cohort.
The incidence of cholangitis was higher in patients with AF than in those without AF [4.2 and 2.54 per 1000 person–years; adjusted HR (95%CI), 1.92 (1.54, 2.41)]. Comparing to subjects without AF, patients with AF had higher risk of cholangitis in the subgroup of ≥65 years (adjusted HR = 1.76, 95%CI = 1.40–2.21), female (adjusted HR = 2.51, 95%CI = 1.74–3.63), male (adjusted HR = 1.60, 95%CI = 1.19–2.14), without comorbidities (adjusted HR = 1.79, 95%CI = 1.23–2.61), and with comorbidities (adjusted HR = 1.85, 95%CI = 1.73–1.99).
AF is associated with a higher incidence of cholangitis. The need of further investigations is mandatory because of the inherent limitations of observational study.
Primary cutaneous apocrine carcinoma of the scalp
Authors: Choi Jun Ho , Oh Hyun Myung , Kim Kwang Seog , Choi Yoo Duk , Joo Sung Pil , Hwang Won Joo , Hwang Jae Ha , Lee Sam Yong 
Published: February 2022

Abstract

Rationale:
Apocrine carcinoma is a rare malignant sweat gland tumor that has been reported in approximately 200 cases. This tumor usually occurs in the axilla, but in rare cases, it can also develop in the scalp. In the present work, we report 2 cases of cutaneous apocrine carcinoma of the scalp.

Patient concerns:
Two men visited our outpatient clinic with recurrence of tumor after undergoing surgery for scalp tumor at another hospital.

Diagnoses:
Brain magnetic resonance imaging of a 56-year old man showed the presence of a 5.0 × 4.5 × 4.4 cm scalp mass in the right parietal region, invading the skull and dura mater and a 2.2 × 2.0 × 0.7 cm bony mass without any skin lesions right next to the scalp mass. Neck magnetic resonance imaging of a 76-year-old man revealed the presence of a well-defined oval mass in the subcutaneous layer of the left occipital scalp and 2 enlarged lymph nodes in the left neck. Definite diagnoses were made postoperatively. The patients were diagnosed with cutaneous apocrine carcinoma. The diagnosis was confirmed through histopathological and immunohistochemical staining tests.

Interventions:
The tumors were removed with a wide safety margin and reconstructive surgery was performed.

Outcomes:
Additional radiotherapy or chemotherapy was performed. Follow-up more than 6 months revealed no recurrence or metastasis.

Lessons:
If accurate diagnosis and treatment had taken place at the initial stages of the primary cutaneous apocrine carcinoma, it would have been possible to prevent recurrence and intracranial invasion. As recurrent primary cutaneous apocrine carcinoma can become aggressive and difficult to treat, even a small mass on the scalp must be evaluated carefully and treated properly.
The clinical efficacy of Shengyu decoction in the treatment of anemia after PFNA for elderly intertrochanteric fracture
Authors: Lu Wei , Zhu Wenhao , Xiao Yu , Hu Hao , Zhang Yunlu , Feng Yanqi , Wan Hongbo , Fan Zhaoxiang , Wu Xuequn 
Published: February 2022

Abstract

Background:
Femoral intertrochanteric fractures (ITF) occur frequently in the elderly, accounting for 45% of all hip fractures. Postoperative anemia after fracture tends to cause ischemia, hypoxia in cells, tissues and organs, increasing the rate of blood transfusion, risk of infection, disability and mortality. Meanwhile, traditional Chinese medicine is widely used in the treatment of anemia for activating blood circulation and removing blood stasis.

Methods:
This study is a prospective, outcome assessor-, and data analyst-blinded randomized controlled clinical trial. The objective of this proposed study was to investigate whether Shengyu Decoction could improve the symptoms of anemia after proximal femoral nail antirotation in elderly ITF patients. After qualifying for screening, patients will be randomized into 2 groups with an allocation ratio of 1:1. Hemoglobin concentration, HBL, and HHS score are outcome measurements. The other outcomes also included time to get out of bed, discharge to home, 30-day readmission rates, and mortality.

Discussion:
ITF is commonly occurring in senior citizens, and those who are senior in age generally suffer 1 or more basic diseases, whose nutritional status is already poor. Trauma and surgical stimulation not only aggravate the existing disease or induce corresponding cardiovascular complications, but also worsen the nutritional status, which can easily cause postoperative anemia in patients. Because of the limited clinical modalities available for the treatment of postoperative anemia after fracture surgery, and most of them have various side effects that are not easily tolerated by the elderly. Therefore, from a traditional Chinese medicine perspective, we proposed a protocol using mild Chinese herbal decoction to treat postoperative anemia in ITF.
Registration number: OSF Registration number: DOI 10.17605/OSF.IO/JQ6ZF.
Pseudomonas keratitis complicated with spontaneous expulsive suprachoroidal hemorrhage
Authors: Yang Ju-Wen 
Published: February 2022

Abstract

Introduction:
Spontaneous expulsive suprachoroidal hemorrhage (SESCH) is a rare condition. The correlation between SESCH and chronic glaucoma has been reported previously. However, few reports have indicated a correlation between infective keratitis and SESCHs.

Patient concerns:
Here, we report the case of an 82-year-old woman with a corneal ulcer who presented with left eye pain for 6 days.

Diagnosis:
We found that she has Pseudomonas keratitis and history of chronic glaucoma.

Interventions and Outcomes:
During admission, her left eye showed elevated intraocular pressure (IOP). Three days later, the eyeball began to bleed and became painful. She had high blood pressure on that day. Hours after complaints of eye pain, intraocular tissue exposure related to eyeball rupture, and SESCH. The patient underwent evisceration and insertion of a silicone ball for the socket reconstruction. Histopathological evaluation revealed acute inflammation of the cornea and the choroidal vessels.

Conclusion:
In elderly patients with infective keratitis and a history of glaucoma and hypertension, it is important to control intraocular pressure and blood pressure and pay attention to the risk of spontaneous expulsive suprachoroidal hemorrhage.
Therapeutic effect of intradiscal pulsed radiofrequency on internal disc disruption
Authors: Kim Dong Hyuck , Jeong Kyung Wook , Jo Wonyeong , Lee So Young , Im Jung A , Jung Jin Yong 
Published: February 2022

Abstract

Rationale:
Discogenic low back pain often persists despite medication and medical intervention. In this study, intradiscal pulsed radiofrequency (PRF) was performed in a patient with discogenic low back pain who did not respond to oral medication, posterior medial branch block, epidural steroid injection, and percutaneous epidural adhesiolysis.

Patient concerns:
A 28-year-old woman visited a pain clinic complaining of low back pain that was scored 8 out of 10 on a numerical rating scale. Her pain was present in any position throughout the day and worsened in the sitting position.

Diagnoses:
Magnetic resonance imaging showed L5-S1 internal discal disruption. Based on the medical history, physical examination, and magnetic resonance imaging, we determined that her pain originated from the L5-S1 disc.

Interventions:
We performed an intradiscal PRF on the affected disc under C-arm fluoroscopy guidance. PRF was performed at 5 Hz, 20-ms pulse width, and 70 V for 15 minutes while ensuring that the electrode tip temperature was maintained below 42°C.

Outcomes:
Immediately after the procedure, the patient's pain subsided. At the 1-month follow-up visit, the patient reported complete relief of her low back pain. The Oswestry disability index, which indicates the degree of disability, improved significantly. She also reported that she could sit for long periods because the pain was reduced. No adverse effects from the procedure were found.

Lessons:
Applying intradiscal PRF seems an effective and safe technique for treating discogenic low back pain.