bluuebunny/crossref_metadata_2025_split huggingface dataset:
A personal history of research on hypertension From an encounter with hypertension to the development of hypertension practice based on out-of-clinic blood pressure measurements
Authors: Imai Yutaka 
Published: September 2022

AbstractIn the 1970s, many people had severe hypertension and related cardiovascular and cerebrovascular diseases; however, antihypertensive treatments were not available at the time. The author encountered such conditions during the initial exposure to medicine. The author subsequently entered the field of hypertension medicine to prevent such conditions and engaged in hypertension research for more than 50 years. The author’s central interest was the physiological and clinical aspects of blood pressure (BP) variability. Out-of-clinic BP measurements were the focus of clinical research. It was anticipated that self-measurement of BP at home (HBP) would improve medical practice surrounding hypertension. To establish evidence-based hypertension medicine, the Ohasama study (an epidemiology based on HBP) was conducted. The study provided firm evidence of the clinical significance of HBP and diagnostic criteria for hypertension and normotension. To establish target HBP levels for antihypertensive therapy, the Hypertension Objective treatment based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study (a prospective intervention study) was also conducted. Application of HBP measurements expanded to obstetric, clinical pharmacology, pathophysiology, and genetic studies. During these studies, crucial information on the clinical significance of BP variability (such as circadian and day-by-day variation of BP, nocturnal BP, white-coat hypertension, and masked hypertension) was established. Finally, the author described the priority of HBP over clinic-measured BP for the diagnosis of hypertension in the 2014 Japanese Society of Hypertension Guidelines. In this article, the author’s history of hypertension research, from the first encounter with hypertension to the construction of guidelines on hypertension, is reviewed.
TRFs and tiRNAs sequence in acute rejection for vascularized composite allotransplantation
Authors: Fang Yuan , Li Haibo , Chen Jingting , Xiong Yao , Li Xu , Sun Binbin , Li Shengli , Zhou Jianda , Wang Shoubao 
Published: September 2022

AbstractIllumina tRFs & tiRNAs-seq analysis was used to characterize the whole transcriptomes of acute rejection caused by vascularized composite allotransplantation (VCA). tRFs & tiRNAs-seq information for muscle samples with VCA was obtained and compared with similar information for same age- and sex-matched healthy control subjects. The expression of 16 tRFs and tiRNAs, including 5 up-regulated target genes and 11 down-regulated target genes, were significantly different. According to bioinformatics analysis and reverse transcription quantitative polymerase chain reaction, we speculate that tiRNA-1-34-Glu-CTC-1 plays an important role in VCA-induced acute rejection by regulating the CACNA1D gene in the MAPK signaling pathway The findings provide the whole-transcriptome signatures of acute rejection for VCA, allowing further exploration of gene expression patterns/signatures associated with the various clinical symptoms of acute rejection for VCA.
AMC 12 atomic mass compilation data extrapolated for atomic masses of nuclei far from the valley of stability
Authors: Venkataramaniah K. , Rao D. S. Shreesha , Scheidenberger C. 
Published: September 2022

AbstractThe experimental mass data from the Atomic Mass Compilation – 2012 (AMC12) has been analyzed for two-neutron separation energies ($${{\boldsymbol{S}}}_{{\bf{2}}{\boldsymbol{n}}}$$

S

2
n

), two-proton separation energies ($${{\boldsymbol{S}}}_{{\bf{2}}{\boldsymbol{p}}}$$

S

2
p

), double-beta decay energies ($${{\boldsymbol{Q}}}_{2{{\boldsymbol{\beta }}}^{-}}$$

Q

2

β

−

), and four-beta decay energies ($${{\boldsymbol{Q}}}_{4{{\boldsymbol{\beta }}}^{-}}$$

Q

4

β

−

) and plotted against neutron number and mass number, respectively. A new weighted slope method of extrapolation, tested for known and new mass measurements, has been used to obtain the extrapolated mass values with better precision for more than 1100 nuclei far from the valley of stability, out of which more than 100 are being reported for the first time. A comparison has been made with five of the popular mass models with reference to experimental extrapolated masses from the present work and the Atomic Mass Evaluation 2016 (AME16). The extrapolated experimental atomic mass data will be very useful for both experimentalists and mass-model theoreticians, as well as in simulations of astrophysical r-processes.
Total cholesterol and high density lipoprotein cholesterol ratio is associated with metabolic syndrome in a very elderly Chinese population
Authors: Huang Gang , Xu Junbo , Zhang Zhen , Cai Lin , Liu Hanxiong , Yu Xiuqiong 
Published: September 2022

AbstractMetabolic syndrome (MetS) is currently a major public health challenge in young, middle aged and elderly population worldwide, but it is still not clear in very elderly population. This study was to investigate the potential association between total cholesterol and high density lipoprotein cholesterol ratio (THR) and MetS in a very elderly population in Chengdu. Totally, 1056 very elderly (aged ≥ 80 years) in Chengdu community were enrolled in this study. Geographic characteristics of participants were collected and laboratory measurement was performed. Metabolic syndrome (MetS) was defined according to the Chinese and the international diabetes federation (IDF) criteria, respectively. Logistic analysis was used to investigate the potential association between the THR and MetS. Receiver operating characteristic curve (ROC) analysis was used to evaluate the efficiency of THR in MetS predicting. Finally, 1038 participants were included in statistical analysis. The mean age was 83.6 ± 3.4 years and 52.6% participants were men and 21.6% suffered from MetS. Participants with MetS had relatively higher waist circumference, body weight, blood pressure, fast plasma glucose level, non-high density lipoprotein cholesterol level and THR. The logistic analysis revealed that the THR was associated with MetS according to both the Chinese (odds ratio (OR): 3.053, 95% confidence interval (CI) 2.464–3.782, P < 0.001) and the IDF criteria (OR: 2.458, 95% CI 2.016–2.995, P < 0.001). ROC analysis found that the area under curve of the THR was 0.800 (95% CI 0.749–0.852, P < 0.001) and 0.727 (95% CI 0.669–0.786, P < 0.001) for predicting MetS according to the Chinese and the IDF criteria, respectively. The THR is associated with MetS in this community very elderly population in Chengdu.
Survey on experiences and attitudes of parents toward disclosing information to children with genetic syndromes and their siblings in Japan
Authors: Kaneko Mikiko , Oba Daiju , Ohashi Hirofumi 
Published: September 2022

AbstractMany parents face the dilemma of when, how, and what to disclose to their children regarding their genetic conditions. The purpose of this study was to learn about the experiences of parents regarding disclosing information to their children with genetic conditions. A questionnaire was sent to 378 parents of children and adolescents with the following genetic syndromes: 22q11.2 deletion syndrome, Beckwith–Wiedemann syndrome, Noonan syndrome, Russell–Silver syndrome, Kabuki syndrome, Williams syndrome, Prader–Willi syndrome, and Sotos syndrome. Findings were analyzed using descriptive statistics for multiple-choice questions. Of the parents surveyed, 158 (41.8%) responded to the questionnaires. The average age of children with genetic syndromes was 12 years. Sixty-seven parents had disclosed relevant information to their children, whereas 91 had not. Among them (who had disclosed information), out of 53 respondents who answered that their affected child had siblings, 50 had disclosed the genetic condition of the affected child to the siblings as well. Sixty-eight out of 91 respondents who had not told information to affected child were planning to disclose the information in the future. Many respondents who had disclosed information did not regret this. They felt good talking about genetic conditions, and had talked about genetic conditions with the affected children following disclosure. This study contributed to our understanding of the attitudes of parents towards disclosing information to children with genetic syndromes.
Impacts of opium addiction on patterns of angiographic findings in patients with acute coronary syndrome
Authors: Abdiardekani Alireza , Salimi Maryam , Sarejloo Shirin , Bazrafshan Mehdi , Askarinejad Amir , Salimi Amirhossein , Bazrafshan Hanieh , Khanzadeh Shokoufeh , Javanshir Salar , Attar Armin , Esmaeili Mohsen , Bazrafshan Drissi Hamed 
Published: September 2022

AbstractOpium is one of the most abused substances in the Middle East. The effects of opium use on coronary artery disease (CAD) are a matter of debate. This study aimed to assess the association between opium use and angiographic findings as well as the complexity of CAD in patients with acute coronary syndrome (ACS) diagnosis. In this case–control study, all patients admitted for coronary angiography from 2019 to 2020 were evaluated. After applying the eligibility criteria, they were categorized into two groups opium and non-opium based on their history of opium use. Both groups were matched regarding the demographic features. The prevalence, location, and severity of obstruction of the vessels were compared between the non-opium and opium groups. The SYNTAX score was also calculated and compared between the two groups. The scores ≤ 22 are considered low risk and the higher scores are a non-low risk. P value < 0.05 is considered significant. A total of 170 patients with a mean age of 61.59 ± 9.07 years were finally enrolled in our study. Regarding the severity of vascular involvement, there was a significant difference between the non-opium and opium groups in LAD (P = 0.025), and PLV (P = 0.018) vessels. From the location points of view of obstructive coronary artery involved segments, only in the PDA (P = 0.006), and LCX (P = 0.004) vessels, a significant difference was observed. Moreover, 47.1% of opium and 30.6% of non-opium use group were in the non-low risk SYNTAX score classification which is a statistically significant difference between these two groups (P value = 0.048). Opium, as an independent risk factor for cardiovascular diseases, can have specific effects on angiographic findings in patients with acute coronary syndrome. Likewise, the complexity of CAD in opium users who undergo percutaneous coronary intervention is significantly higher.
Cognitive Requirements of the Phonological Tests Affect Their Ability to Discriminate Children With and Without Developmental Dyslexia
Authors: Dorofeeva Svetlana V. , Iskra Ekaterina , Goranskaya Daria , Gordeyeva Elizaveta , Serebryakova Margarita , Zyryanov Andrey , Akhutina Tatiana V. , Dragoy Olga 
Published: September 2022

Purpose:The main purpose of this study was to investigate whether the performance on each of seven phonological processing (PP) tests from the Russian Test of Phonological Processing (RuToPP), with their varying levels of linguistic complexity and composite phonological indices, are significant predictors of developmental dyslexia (DD) and can reliably differentiate children with and without reading impairment. Additionally, we examined the general contribution of phonological skills to text reading fluency in children with various levels of reading performance.Method:A total of 173 Russian-speaking 7- to 11-year-old children participated in this study: 124 who were typically developing (TD) and 49 who had been diagnosed with DD. We assessed reading fluency with a standardized reading test and PP with the RuToPP. We investigated the potential of phonological skills to predict the presence or absence of a dyslexia diagnosis using multinomial logistic regression, receiver operating characteristic (ROC) curve analysis, and calculations of the sensitivity and specificity of each test and index. The contribution of phonological skills to reading fluency was also assessed in a mixed group of children.Results:Six of seven RuToPP tests were significant predictors of dyslexia. However, while the RuToPP correctly identified 93%–99% of TD children, for children with dyslexia, it ranged from 4% to 47% depending on the test. In a mixed group of children with and without dyslexia, performance in the more complex phonological tests was a stronger predictor of reading fluency.Conclusions:Our findings are consistent with the literature on predictors of literacy skills and dyslexia while uniquely demonstrating the impact of the complexity level of the phonological tests on the classification outcome. PP is a significant and necessary predictor of reading skills, but it is not sufficient for diagnostic purposes.Supplemental Material:https://doi.org/10.23641/asha.20779294
“Response to Treatment” in Dysphagia Rehabilitation: Factors for Consideration in Clinical Practice and Future Research
Authors: Krekeler Brittany Nicole , Rogus-Pulia Nicole 
Published: September 2022

Purpose:
Some patients experience dysphagia that is not responsive to treatment. Despite application of appropriate evidence-based interventions, decreased swallow safety and/or efficiency persists. In order to provide the best opportunity for therapeutic efficacy, it is important to attempt to identify and characterize source of nonresponse. The definition of “nonresponse” will likely vary based on each patient depending on etiology and patient-specific goals. The purpose of this article is to outline some potential sources for patient nonresponse to dysphagia rehabilitation. We also aim to identify gaps in the literature that should be addressed in future research, to both further our understanding of nonresponse to dysphagia therapies and to better understand how to address nonresponse to improve patient outcomes.

Method:
Several potential sources of nonresponse are described, and specific areas of dysphagia rehabilitation research that require further investigation are discussed.

Results:
Based on available evidence, several sources of nonresponse to treatment are possible. First, application of interventions that are nonspecific to visualized impairments in swallow physiology could result in lack of treatment response. Patient population and etiology of dysphagia should also be considered when selecting a treatment approach to ensure that the available evidence supports use of that approach within the specific patient group. Patient adherence with rehabilitation protocols may affect response to treatment, although effects of adherence on dysphagia therapy efficacy are not fully understood. Furthermore, optimal dosing protocols to maximize benefit from rehabilitation approaches have not been fully appreciated in the literature.

Conclusions:
Understanding sources of nonresponse to treatment in dysphagia rehabilitation is multifaceted. Use of current literature to guide practice and therapy planning will help maximize patient benefit. However, in cases where the reason for nonresponse cannot be identified, it may be that the source lies in an area of dysphagia rehabilitation that has yet to be fully explored, including therapy dose and patient adherence among others.
Allogene heterotope Nierentransplantation
Authors: Matevossian Edouard , Kolliogianis Dionysios , Kemmner Stephan , Thorban Stefan 
Published: September 2022

ZUSAMMENFASSUNGZusammenfassend lässt sich klinisch evident bestätigen, dass eine allogene heterotope Nierentransplantation von Säuglings- und Neugeborenenspendern eine praktikable langfristige Option für die Behandlung von Nierenerkrankungen erwachsener normalgewichtiger Empfänger mit terminaler dialysepflichtiger Niereninsuffizienz darstellt. Unsere Daten zur Funktionalität der Transplantate im Langzeitverlauf zeigen, dass eine Nierentransplantation von solch kritischen Spendern in Transplantationszentren mit langjähriger klinischer Erfahrung in einem interdisziplinären Team eine bewährte Option ist. Allerdings bedarf es einer strengen Auswahl des Empfängers und einige Fakten sprechen nach Übersicht der zitierfähigen Fachliteratur für das erhöhte Risiko eines frühen Transplantatverlusts infolge einer Transplantat-Venen-Thrombose. En bloc entnommene und heterotop en bloc transplantierte Nieren von kleinen pädiatrischen/neonatalen Spendern haben ähnliche Überlebens- und Funktionsraten im Vergleich zu Transplantaten von größeren traditionellen erwachsenen Spendern und überlegene Ergebnisse im Vergleich zu denen von postmortalen Spendern mit erweiterten Kriterien.
Management von Patient*innen mit Polytrauma nach Nierentransplantation
Authors: Thorban Stefan , Kanz Karl-Georg , Matevossian Edouard 
Published: September 2022

ZUSAMMENFASSUNGNach erfolgreicher Nierentransplantation (NTx) können Patient*innen wieder vermehrt an Alltagsaktivitäten und Sport teilnehmen. Über die Behandlung von Patient*innen mit NTx nach einem Polytrauma gibt es nur wenige Studien und kaum Behandlungsempfehlungen. Aufgrund der besonderen anatomischen Lage des Transplantats in der Fossa iliaca, der Einnahme von Immunsuppressiva mit erhöhter Infektionsneigung, dem chronischen Grundleiden, eines erhöhten Thromboserisikos und der immunologischen Reaktion in der Sepsis mit drohendem Organversagen ergeben sich besondere Herausforderungen bei der Therapie dieser Patient*innen im Schockraum. In der vorliegenden Arbeit werden besondere Risikofaktoren dieser Patient*innen aufgrund der Immunsuppression sowie die inflammatorische Reaktion des Unfallverletzten und eine mögliche Änderung des Immunstatus mit Schwerpunkt auf das Nierentransplantat untersucht. Außerdem werden entsprechende Empfehlungen zum Management im Schockraum von Menschen mit einem Nierentransplantat vorgestellt und diskutiert.
Konzepte zur Reduktion der Lärmbelastung auf der Intensivstation
Authors: Theuerkauf Nils-Ulrich , Putensen Christian , Schewe Jens-Christian 
Published: September 2022

ZusammenfassungDie Lärmbelastung auf der Intensivstation ist ein allgegenwärtiges, erhebliches Problem für Patienten und Personal. Viele maßgebliche Lärmquellen sind mitverantwortlich für die häufigen
Schlafstörungen der Patienten, die das Auftreten eines Delirs begünstigen. Der Beitrag fasst die aktuelle Evidenz zur Entstehung lärmassoziierter Auswirkungen zusammen und zeigt Optionen zur
Lärmreduktion und Verbesserung der Therapie von Intensivpatienten auf.
Ernährungsaspekte bei Osteoporose
Authors: Schultz Katharina , Maus Uwe , Brabant Thomas , Wergen Niklas , Beyersdorf Christoph 
Published: September 2022

ZusammenfassungOsteoporose und Sarkopenie sind entscheidende Faktoren für den altersabhängigen Anstieg des Frakturrisikos. Eine knochenbewusste Ernährung ist entscheidender Bestandteil sowohl der Prävention als auch der Basistherapie der Osteoporose. Eine ausreichende Zufuhr von Calcium als wichtiger Bestandteil des Knochengewebes ist sowohl zur Erreichung der peak bone mass während der Wachstumsphase als auch bei Osteoporose essentiell. Gerade auch unter einer medikamentösen Osteoporosetherapie sollte auf eine ausreichende Zufuhr geachtet werden. Ein Großteil der europäischen Gesellschaft weist einen Vitamin-D-Mangel auf. Neben einem Effekt auf die Calciumhomöostase und die Knochenmineralisation, beeinflusst Vitamin D auch die Muskulatur und das Sturzrisiko. Gerade eine kombinierte Substitution von Calcium und Vitamin D scheint sich günstig auf das Frakturrisiko auszuwirken. Ebenso ist ein Mangel von Vitamin K weit verbreitet. Vitamin K hat eine relevante Funktion bei der Knochenmineralisation sowie bei der Verhinderung von ektopen Mineralisationen. Welche Wirkung eine Substitution auf das Frakturrisiko hat, wird aktuell noch kontrovers diskutiert. Proteine sind ein wesentlicher Baustein von Muskulatur und Knochen. Darüberhinaus führt eine erhöhte Zufuhr zur Sekretion von IGF-I, welches verschiedene günstige Effekte auf den Knochenstoffwechsel hat. Bezüglich einer Senkung des Frakturrisikos sind auch hier inkonsistente Studienergebnisse zu finden. Der über längere Zeit postulierte negative Effekt von tierischem Eiweiß auf die Knochenhomöostase konnte in neueren Studien nicht verifiziert werden.
Short-Term Clinical and Radiographic Outcome after Stabilization of Femoral Capital Physeal Fractures with Cortical Positional Screws in 39 Cats
Authors: Vink Joris Johannes Wilhelmus Gerardus , Hubers Mike Willem Laurens , den Hertog Erik , Schaeffer Ingrid Geraldine Fernanda , van Zuilen Dick , Maarschalkerweerd Roelof Jozef , van Klaveren Nicolien Jacoba 
Published: September 2022

AbstractObjective The aim of this study was to report the short-term clinical and radiographic outcome for the treatment of femoral capital physeal fractures with cortical positional screws in cats.Study Design Medical records and radiographs of cats with femoral capital physeal fractures stabilized with cortical positional screws were retrospectively reviewed. Signalment, bodyweight, femoral head affected, fracture classification, fracture reduction, implants, concurrent orthopaedic injuries, osteoarthritis, femoral neck osteolysis, complications and 6-week follow-up clinical results were recorded. A short- to long-term follow-up was performed by telephone questionnaire with the owners.Results Forty-six fractures in 39 cats met the inclusion criteria. In 45/46 fractures, radiographic signs of bone healing were present and 35/39 cats were assessed as walking normally by a veterinarian at 6-week follow-up. There was a significant increase in radiographic signs of osteoarthritis (p=0.037) and femoral neck osteolysis (p=0.001) on 6-week follow-up radiographs. Pre- and postoperative osteoarthritis and femoral neck osteolysis were not associated with clinical outcome. The mean follow-up period for the telephone questionnaire was 48 months (range, 5–147 months). Seven out of 25 owners reported a gait abnormality in the short- to long-term.Conclusion Femoral capital physeal fractures in cats can be treated successfully with the use of cortical positional screws. This technique may be considered as an alternative to other primary fixation techniques and salvage procedures for the treatment of femoral capital physeal injuries in cats. This technique seemed successful in cats with a low-grade preoperative femoral neck osteolysis.
Differential equations for the closed geometric crystal chains
Authors: Takagi Taichiro 
Published: September 2022

Abstract
We present two types of systems of differential equations that can be derived from a set of discrete integrable systems which we call the closed geometric crystal chains. One is an extended Lotka–Volterra type system, and the other seems to be generally new but reduces to a previously known system in a special case. Both equations have Lax representations associated with what are known as the loop elementary symmetric functions, which were originally introduced to describe products of affine type A geometric crystals for symmetric tensor representations. Examples of the derivations of the continuous time Lax equations from a discrete time one are described in detail, where a novel method of taking a continuum limit by assuming asymptotic behaviors of the eigenvalues of the Lax matrix in Puiseux series expansions is used.