bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knockdown of G1P3 inhibits cell proliferation and enhances the cytotoxicity of dexamethasone in acute lymphoblastic leukemia
Authors: Zou Liping , Liu Zhirui , Li Xueer , Liu Liping , Zhu Ying 
Published: February 2022

Abstract
Drug resistance contributes to treatment failure and relapse in acute lymphoblastic leukemia (ALL). G1P3 (also known as IFI6, interferon, alpha-inducible protein 6) has been regarded as an antiapoptotic protein in myeloma cells and contributes to chemoresistance in breast cancer. However, the role of G1P3 in the proliferation and chemosensitivity of ALL is largely unknown. Data from colony formation and bromo-deoxyuridine (BrdU) incorporation assays showed that siRNA-mediated downregulation of G1P3 repressed cell proliferation of glucocorticoids-resistant human leukemic cells (CEM-C1), while overexpression of G1P3 promoted the cell proliferation. Cell apoptosis of CEM-C1 was suppressed by G1P3 overexpression accompanied by a decrease in cleaved caspase-3 and caspase-9. Knockdown of G1P3 increased protein expression of cleaved caspase-3 and caspase-9 to promote the cell apoptosis of CEM-C1. Moreover, silencing of G1P3 reduced cell viability and promoted cell apoptosis of CEM-C1 exposed to dexamethasone. The proapoptotic protein B-cell lymphoma 2 interacting mediator of cell death (Bim) was enhanced by the interference of G1P3 in CEM-C1. Silencing of Bim attenuated G1P3 interference-induced decrease in cell viability and increase in cell apoptosis in CEM-C1 exposed to dexamethasone. Conclusively, knockdown of G1P3 inhibited cell proliferation of ALL and sensitized glucocorticoid-resistant ALL cells to dexamethasone through upregulation of Bim-mediated cell apoptosis.
Channel estimation via GAMP for millimeter wave hybrid massive MIMO systems
Authors: Huang Qiufang , Hu Anzhong 
Published: February 2022

Abstract
In this paper, we study the channel estimation problem for the millimeter wave (mm-wave) hybrid massive multiple-input multiple-output (MIMO) system. Based on the sparsity exhibited by the mm-wave channel in the angular domain, we select a portion of the beams that contribute to the communication process from the beamspace. Then, only the channel coefficients in the selected beamspace need to be estimated. The channel estimation problem is converted into a sparse signal reconstruction problem and solved by employing the generalized approximate message passing (GAMP) algorithm with Laplace distribution. The scale parameter of distribution is designed by analyzing the variance of the partial channel coefficients. Because only the partial channel coefficients need to be estimated, the computational complexity of the proposed GAMP approach is much lower than other methods. Simulation results show that the proposed channel estimation scheme exhibits significant advantages both in terms of estimation accuracy and spectral efficiency.
The impact of sulphonation and hot-pressing on low-energy high-temperature chemi-thermomechanical pulp
Authors: Joelsson Tove , Persson Erik , Pettersson Gunilla , Norgren Sven , Svedberg Anna , Engstrand Per 
Published: February 2022

Abstract
Hot-pressing high-yield pulp-based paper, at a temperature well above the softening temperature of lignin, increases paper density and strength. Here, it is investigated whether improved paper strength can be achieved and whether lower pressing temperatures can be used in combination with the increased sulphonation of high-temperature chemi-thermomechanical pulp (HTCTMP). Moist paper sheets from low-energy Norway spruce HTCTMP were hot pressed at temperatures up to 270 °C. Sulphite charges of 25–120 kg/bdt were used during impregnation, preheating, and refining at 180 °C with an electric energy demand of 370–500 kW h/bdt to a shive content of 1%. The pulps were mixed with 20% bleached unrefined kraft pulp to ensure that the sheet formation would not be hampered by the pulp coarseness. A tensile index of 70 kN m/kg was reached with the highest sulphite dosage at a pressing temperature of only 150 °C, versus 60 kN m/kg for the corresponding market CTMP. To obtain high wet strength, the highest temperature was required, while the sulphite charge was found to be of minor importance. This study has shown that it is possible to obtain strong and wet-stable paper products from HTCTMP, with a yield of 94–96% and a low energy demand at reduced pressing temperature.
Aluminum–Lithium alloy development for thixoforming
Authors: Sauermann R. , Friedrich B. , Püttgen W. , Bleck W. , Balitchev E. , Hallstedt B. , Schneider J.M. , Bramann H. , Bührig-Polaczek A. , Uggowitzer P.J. 
Published: February 2022

Abstract
This paper presents a scientific contribution to the development of lightweight/high-performance Al –Li alloys suitable for semi-solid processing. Thermodynamic calculations identified the most promising compositions with focus on the solidus – liquidus interval, fraction of solid-versus-temperature and phase reactions. The synthesis of Al –Li precursor billets was performed by overpressure induction melting in controlled atmosphere. DTA and microstructure investigations on Al –Li specimens were carried out as well as thixocasting trials of demonstrator components. New rheocasting of Al –Li alloys was investigated to identify the potential of this alternative precursor material route. It is shown that specifically developed Al –Li alloys offer great potential for semi-solid manufacturing.
Design and optimization of an integrated gamma ray scanning system for the uranium sample
Authors: Hou Suxia , Luo Jijun 
Published: February 2022

Abstract
An integrated gamma ray scanning system has been designed and built to extend that localizes and quantifies highly enriched uranium sample. The detection mechanisms of the two modes (segmented gamma scanner and tomographic gamma scanning) are analyzed respectively. Moreover, the parameters influence of speed and the deviation of the measurement accuracy are analyzed for the uranium sample. In view of these problems, the system has improved by the optimization processing, which include the optimization of the collimator opening for detector, the crosstalk and the time step. Finally, the experiment were investigated and discussed in detail. The single measurement time of the system can reduce to about 30 min with an error of less than ±5%, so the measurement accuracy and the speed are enhanced effectively. The system has broad application prospects in the fields of nuclear safety, radioactive recyclables and non-destructive measurement of nuclear waste.
Single-phase flow heat transfer characteristics in helically coiled tube heat exchangers
Authors: Akgul Dogan , Kirkar Safak Metin , Onal Busra Selenay , Celen Ali , Dalkilic Ahmet Selim , Wongwises Somchai 
Published: February 2022

Abstract
The aim of this review is to present a summary of the published papers of the heat transfer and pressure drop characteristics for single-phase flow in helically coiled tubes. The effect of geometrical parameters such as curvature ratio, coil pitch and working conditions such as Reynolds number, Dean number, flow rate and flow arrangement on heat transfer and pressure drop in helically coiled tubes are determined in the light of the experimental, numerical and analytical studies in the literature. Also, the effect of using nanofluids in comparison with conventional fluids, using enhanced surfaces such as corrugated, micro-finned, dimpled with regards to smooth surfaces and wire coil insert usage in helically coiled tubes are discussed. The correlations proposed for determination of Nusselt number and friction factor in helically coiled tubes are presented in detail separately under laminar and turbulent flow regimes. The studies show that usage of helically coiled tube merely gives higher heat transfer rate and pressure drop in comparison to straight one, additionally, the heat transfer performance increases with the inclusion of the combination of other passive heat transfer enhancement methods to helically coiled tube. Moreover, the subject of single-phase flow in helically coiled tubes is ascertained to be worth researching due to the fact that there are limited number of studies and is still no empirical or analytical model/correlation in the case of using enhanced surfaces and wire coil insert. Forthcoming researches on this issue in the near future will be considered as pioneer ones in literature.
Flow and heat transfer characteristics of a nanofluid as the coolant in a typical MTR core
Authors: Elbakhshawangy Hesham F. , Abdelmaksoud Abdelfatah , Abd El-Kawi Osama S. 
Published: February 2022

Abstract
The purpose of this work was to perform a thermal–hydraulic numerical analysis of a nanofluid as the coolant in a typical MTR (material testing reactor) core. Numerical simulation was carried out for turbulent flow of water based nanofluid of different concentrations of Al2O3 nanoparticles through a sub-channel of a typical MTR core subjected to cosine shape heat flux at various values of Reynolds number using the Ansys-Fluent computer code. The optimum performance of the studied nanofluid as a coolant in MTR core was determined by the determination of the conditions under which the total entropy generation due to both heat transfer and fluid flow had a minimum value. The results showed that this condition was at Re = 4.8 × 104. The studied range of Reynolds number (Re) and particle concentration (ϕ) were 2.5 × 104 ≤ Re ≤ 5.6 × 104 and 0% ≤ ϕ ≤ 9% respectively. Results for local and average heat transfer and flow characteristics were presented. For the studied range of Reynolds number and particle concentration, four new correlations were developed. Two correlations relating Nusselt number and friction coefficient with the parameters Re and ϕ whereas the other two correlations were one relating Nusselt number with Reynolds and Prandtl numbers and the other relating the friction coefficient with Reynolds number.
Scattering asymmetry and circular dichroism in coupled PT-symmetric chiral nanoparticles
Authors: Chen Xiaolin , Wang Hongfei , Li Jensen , Wong Kwok-yin , Lei Dangyuan 
Published: February 2022

Abstract
We investigate the scattering properties of coupled parity-time (PT) symmetric chiral nanospheres with scattering matrix formalism. The exceptional points, i.e., spectral singularities at which the eigenvalues and eigenvectors simultaneously coalesce in the parameter space, of scattering matrix can be tailored by the chirality of the nanospheres. We also calculate the scattering, absorption and extinction cross sections of the PT-symmetric chiral scatter under illumination by monochromatic left- and right-circularly polarized plane waves. We find that the scattering cross section of the nanostructures exhibits an asymmetry when the plane waves are incident from the loss and gain regions, respectively, especially in the broken phase, and the optical cross section exhibits circular dichroism, i.e., differential extinction when the PT-symmetric scatter is endowed with chirality. In particular, under illumination by linearly polarized monochromatic plane waves without intrinsic chirality, the ellipticity of scattered fields in the forward direction, denoting the chirality of light, becomes larger when the scatter is in the PT-symmetry-broken phase. Our findings demonstrate that the gain and loss can control the optical chirality and enhance the chiroptical interactions and pave the way for studying the resonant chiral light–matter interactions in non-Hermitian photonics.
Worship or weight? A Bronze Age ‘goddess with a necklace’ from River Tollense (NE Germany)
Authors: Terberger Thomas , Borgwardt Ronald , Krüger Joachim , Lorenz Sebastian , Schmidt Jens-Peter , Rahmstorf Lorenz 
Published: February 2022

Abstract
The Tollense valley in northeast Germany is well known for its substantial evidence indicating a violent conflict dated to the early 13th century BC (Period III of the Nordic Bronze Age). This article presents a significant new find from a later Bronze Age context, found in the river at a known Bronze Age valley crossing (site Weltzin 13) by Ronald Borgwardt in 2020. The small bronze figurine (14.7 cm tall) has an egg-shaped head with a prominent nose, looped arms, a neckring, two knobs signifying breasts, a belt, an indication of a female sex and two slightly differently shaped legs. In the 19th century a similar female statuette was found near the village of Klein Zastrow, just a few kilometres from the valley crossing, but mostly these figurines are known from Zealand and Scania. Belts are only present on the statuettes from Zealand and northern Germany, and their presence suggests a close connection between the figures from these areas. Typological evidence places the figure from the Tollense river to the Late Bronze Age (Periods V–VI). Some time ago the figures were discussed as possible balance weights, but their small number does not support this theory. With a mass of 155 g, however, the new figure could be seen as a multiple of 26 g, the previously proposed weight unit of the time. The new find further suggests a connection between the find spots of the statuettes and routes of communication. There is little evidence to support an interpretation as a goddess. The deposition of the new figure at a valley crossing where hundreds of years before a violent conflict happened, might indicate that this was still a place of commemoration.
Agency, sentiment, and risk and uncertainty: fears of job loss in 8 European countries
Authors: Clark Gordon L. 
Published: February 2022

Abstract
How people assess their prospects and act accordingly is anchored in time and space. But context is only half the story. Human beings share predispositions in favour of the here and now, discounting the future, and risk aversion. This paper provides a framework for integrating cognition with context in economic geography focusing upon agency, resources, and risk and uncertainty in European labour markets. In doing so, it seeks to avoid essentialising the individual while ensuring that the resulting framework does not leave individuals as cyphers of time and place. The framework is illustrated by reference to individual’s assessments of the consequences of technological change for their employment prospects in a multicountry European setting. Implications are drawn for a behavioural economic geography that is policy relevant.
The Rhetoric of Matthean “Small Faith”
Authors: Seglenieks Christopher 
Published: February 2022

Abstract
Matthew uses ὀλιγόπιστος to critique inadequate faith from the disciples, adapting already linked Markan pericopes to create a set with a distinct rhetorical function. For the Gospel audience, these function together to call people to the sort of wholehearted trust exemplified in the first use of the term (6,25–34), while developing this ideal in a christological direction. Linguistic studies on the role of the vocative highlight how ὀλιγόπιστος is used to effect this goal, as it serves to recharacterize the disciples, drawing attention to the narrative frame, and emphasising the imperative force of Jesus’ rhetorical questions.
Adam’s Animal Farm: A Fresh Reading of the Anthropological-Hamartiological Framework of the Apocalypse of Moses
Authors: Koning Harro 
Published: February 2022

Abstract
A commonly recognized feature of the Apocalypse of Moses is its ethical-inferential orientation. However, the present article seeks to show that this does not just manifest itself in retrospective reflection, but is also exemplified narratologically in the attacks on Cain, Abel, and Seth. Far from being superfluous to the main narrative, these incidents provide us with a paradigm for understanding the Apocalypse’s anthropological-hamartiological framework in the post-paradisiacal world: The one who does what is good will send both devil and beast into flight, but the one who does not will be overcome by them. In order to substantiate this thesis, the article compares the Apocalypse to the works of Philo and the Testaments of the Twelve Patriarchs.
Integrated Amygdala, Orbitofrontal and Hippocampal Contributions to Reward and Loss Coding Revealed with Human Intracranial EEG
Authors: Manssuer Luis , Qiong Ding , Wei Liu , Yang Ruoqi , Zhang Chencheng , Zhao Yijie , Sun Bomin , Zhan Shikun , Voon Valerie 
Published: February 2022

Neurophysiological work in primates and rodents have shown the amygdala plays a central role in reward processing through connectivity with the orbitofrontal cortex (OFC) and hippocampus. However, understanding the role of oscillations in each region and their connectivity in different stages of reward processing in humans has been hampered by limitations with noninvasive methods such as poor spatial and temporal resolution. To overcome these limitations, we recorded local field potentials (LFPs) directly from the amygdala, OFC and hippocampus simultaneously in human male and female epilepsy patients performing a monetary incentive delay (MID) task. This allowed us to dissociate electrophysiological activity and connectivity patterns related to the anticipation and receipt of rewards and losses in real time. Anticipation of reward increased high-frequency gamma (HFG; 60–250 Hz) activity in the hippocampus and theta band (4–8 Hz) synchronization between amygdala and OFC, suggesting roles in memory and motivation. During receipt, HFG in the amygdala was involved in outcome value coding, the OFC cue context-specific outcome value comparison and the hippocampus reward coding. Receipt of loss decreased amygdala-hippocampus theta and increased amygdala-OFC HFG amplitude coupling which coincided with subsequent adjustments in behavior. Increased HFG synchronization between the amygdala and hippocampus during reward receipt suggested encoding of reward information into memory for reinstatement during anticipation. These findings extend what is known about the primate brain to humans, showing key spectrotemporal coding and communication dynamics for reward and punishment related processes which could serve as more precise targets for neuromodulation to establish causality and potential therapeutic applications.SIGNIFICANCE STATEMENTDysfunctional reward processing contributes to many psychiatric disorders. Neurophysiological work in primates has shown the amygdala, orbitofrontal cortex (OFC), and hippocampus play a synergistic role in reward processing. However, because of limitations with noninvasive imaging, it is unclear whether the same interactions occur in humans and what oscillatory mechanisms underpin them. We addressed this issue by recording local field potentials (LFPs) from all three regions in human epilepsy patients during monetary reward processing. There was increased amygdala-OFC high-frequency coupling when losing money which coincided with subsequent adjustments in behavior. In contrast, increased amygdala-hippocampus high-frequency phase-locking suggested a role in reward memory. The findings highlight amygdala networks for reward and punishment processes that could act as more precise neuromodulation targets to treat psychiatric disorders.
Insulin therapy and biliary tract cancer: insights from real-world data
Authors: Qi Xiaohui , He Ping , Yao Huayan , Sun Huanhuan , Qi Jiying , Cao Min , Cui Bin , Ning Guang 
Published: February 2022

Objective
The association between insulin therapy and the risk of biliary tract cancer (BTC) is uncertain. We aimed to assess this risk in type 2 diabetic patients.

Methods
Using electronic medical data from the Shanghai Hospital Link database, 202,557 patients with type 2 diabetes (164,997 insulin never-users and 37,560 insulin ever-users) were identified in this study between January 1, 2013, and December 31, 2016, with follow-up until December 31, 2019. By propensity score matching, an ever-user was matched with a never-user. Cox proportional hazards regression analysis was used to estimate risk ratios (HRs) and 95% CIs for three subtypes of BTC (intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC), and gallbladder cancer (GBC)).

Results
At a mean follow-up of 5.33 years, 143 cases of BTC were observed. The crude incidence rates (per 100,000 person-years) of ECC, ICC, and GBC in ever-users:never-users were 10.22:3.63, 2.04:2.04, and 8.17:6.01, respectively. Insulin therapy was associated with an increased risk of ECC (HR, 4.10; 95% CI, 1.54–10.92; P  = 0.005) compared to patients who never used insulin. No statistically significant results were observed for insulin and ICC/GBC. Consistent results were also found in the original cohort.

Conclusions
The relationship between insulin therapy and BTC is type-specific. Further studies are warranted to provide evidence on the identification of ECC risk groups among type 2 diabetic patients.
Association between vitamin D and bisphenol A levels in an elderly Italian population: results from the InCHIANTI study
Authors: Brandi Maria Luisa , Bandinelli Stefania , Iantomasi Teresa , Giusti Francesca , Talluri Eleonora , Sini Giovanna , Nannipieri Fabrizio , Battaglia Santina , Giusti Riccardo , Egan Colin Gerard , Ferrucci Luigi 
Published: February 2022

Objective
This study aimed to evaluate the association between the endocrine-disrupting chemical, bisphenol A (BPA) on circulating levels of 25-hydroxy vitamin D (25(OD)D) and other vitamin D metabolites in an elderly population in Italy.

Methods
This was a retrospective analysis of the InCHIANTI Biobank in Italy. The association between vitamin D metabolites namely 1,25(OH)D, 25(OH)D, parathyroid hormone (PTH) and BPA levels were evaluated. Multiple regression models were used to examine the association between predictor variables with 1,25(OH)D or 25(OH)D levels.

Results
Samples from 299 individuals aged 72.8 ± 15.7 years were examined. Mean levels of BPA, 1,25(OH)D and 25(OH)D were 351.2 ± 511.6 ng/dL, 43.7 ± 16.9 pg/mL and 20.2 ± 12.1 ng/mL, respectively. One hundred eighty individuals (60.2%) were deficient (<20 ng/mL) in 25(OH)D and this population also presented higher BPA levels (527.9 ± 1289.5 ng/dL vs 86.9 ± 116.8 ng/dL, P  < 0.0001). Univariate analysis revealed that BPA levels were negatively correlated with both 1,25(OH)D (r= −0.67, P  < 0.0001) and 25(OH)D (r= −0.69, P  < 0.0001). Multivariate regression revealed that PTH (β: −0.23, 95% CI: −0.34, −0.13, P  < 0.0001) and BPA (β: −0.25, 95% CI: −0.3, −0.19, P  < 0.0001) remained significantly associated with 25(OH)D levels while BPA was also associated with 1,25(OH)D levels (β: −0.19, 95% CI: −0.22, −0.15, P  < 0.0001). Receiver operating characteristic curve analysis showed that a BPA concentration of >113 ng/dL was the best cut-off to predict individuals deficient in 25(OH)D (area under the curve: 0.87, 95% CI: 0.82–0.90, P  < 0.0001).

Conclusion
The strong negative association between BPA and vitamin D in this elderly population warrants further investigation, particularly since this population is already at greatest risk of hypovitaminosis and fracture.