bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Friction Mechanism of ZDDP Tribofilm Based on in situ AFM Observation of Nano-Friction and Adhesion Properties
Authors: Sato Kaisei , Watanabe Seiya , Sasaki Shinya 
Published: August 2022

AbstractZinc dialkyl dithiophosphate (ZDDP) is a typical anti-wear additive that forms tribofilm on sliding surfaces and prevents adhesion wear but increases the friction force. In this study, the nano-friction and adhesion properties of ZDDP tribofilms were investigated by performing in situ observations by atomic force microscopy to explore the relationship between the formation process and physical properties of ZDDP tribofilm. The results showed that the nano-friction force increased with the formation of the ZDDP tribofilm. In addition, the adhesion force on the ZDDP tribofilm increased with the friction force. It was confirmed that the Young's modulus and nanoindentation hardness of the ZDDP tribofilms were lower than those of steel. However, the contact areas calculated using the Derjaguin–Muller–Toporov (DMT) contact theory were similar. In addition, the shear strengths calculated using the DMT model of the ZDDP tribofilm were substantially higher than those of steel.
Why Is It So Challenging to Measure Residual Stresses ?
Authors: Schajer G. S. , Prime M. B. , Withers P. J. 
Published: August 2022

Abstract
Background
Residual stresses have a “hidden” character because they exist in a material without the presence of any external loads. They cannot easily be added or subtracted in a quantified manner, as is done when measuring applied stresses, and so are much more challenging to measure.

Objective
The objective here is to identify and describe the various features that make residual stress measurement methods challenging and to consider the ways that these challenges can be addressed in practice.

Methods
Various of the most common residual stress measurements methods are considered and the challenges associated with them are identified and classified.

Results
Five major challenges for residual stress measurements, and the approaches used for their resolution, are identified.

Conclusions
Despite the various challenges that need to be overcome, residual stress measurements can be successfully undertaken in practice. The most significant feature for success is a highly skilled and knowledge practitioner.
Searching for constituents from plants in geographically characterized areas, Egypt, Madagascar, and Okinawa
Authors: Sugimoto Sachiko 
Published: August 2022

AbstractSecondary metabolites may not be produced under some conditions, and in most cases, their function and significance in the producing organisms is unknown. Conversely, there are some that are produced for readily understood reasons, for example, toxic substances as defensive substances against invaders, or volatile substances that attract other species of organisms. These secondary metabolites also contribute to our health. However, there has not been sufficient research to evaluate them from a pharmacological perspective, and much progress is expected in this area in the future. About 90% of the existing plants have not been studied for their chemical components and biological activities (Kazuki Saito in Bunshun shinsho 1119, pp. 119–126. ISBN 978-4-16-661119-5, 2017). On this basis, we have been searching for the constituents of unknown plants, and whose constituents have not been studied extensively. In this paper, the authors have reviewed some of their previous searching for constituents from plants in geographically characterized areas, Egypt, Madagascar, and Okinawa.
PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis
Authors: Wang Yuan , Sui Yutong , Niu Ye , Liu Dan , Xu Qi , Liu Feilin , Zuo Kuiyang , Liu Mingsheng , Sun Wei , Wang Ziyu , Liu Zinan , Zou Fei , Shi Jiahong , Liu Xiaomei , Liu Jinyu 
Published: August 2022

AbstractStem cell senescence and depletion are major causes of aging and aging-related diseases. The NAD (Nicotinamide adenine dinucleotide) – SIRT1 (Silent Information Regulator 1) – PARP1 (Poly (ADP-ribose) polymerase-1) axis has gained interest owing to its significant role in regulating stem cell senescence and organismal aging. A recent study from our lab showed that pre-B-cell leukemia transcription factor1 (PBX1) overexpression attenuates hair follicle-derived mesenchymal stem cells (HF-MSCs) senescence and apoptosis by regulating ROS-mediated DNA damage via PARP1 downregulation; thus, suggesting that PARP1 downregulation is a common manifestation of the roles of both PBX1 and SIRT1 in HF-MSCs senescence attenuation, and implying a potential link between PBX1 and SIRT1. To this end, HF-MSCs overexpressing PBX1, overexpressing both PBX1 and PARP1, downregulating SIRT1, and overexpressing PBX1 as well as downregulating SIRT1 were generated, and senescence, apoptosis, DNA damage, and repair biomarkers were analyzed. Our results showed that (1) PBX1 overexpression alleviated HF-MSCs senescence and apoptosis accompanied by SIRT1 upregulation, PARP1 downregulation, and increased intracellular NAD and ATP levels. (2) SIRT1 knockdown enhanced cellular senescence and apoptosis, accompanied by increased ROS accumulation, DNA damage aggravation, and decreased intracellular NAD and ATP levels. (3) PBX1 overexpression rescued HF-MSCs senescence and apoptosis induced by SIRT1 knockdown. (4) PBX1 rescued PARP1 overexpression-mediated ATP and NAD depletion, accompanied by increased SIRT1 expression. Collectively, our results revealed that a positive interaction feedback loop exists between PBX1 and SIRT1. To the best of our knowledge we are the first to report that there is a PBX1-SIRT1-PARP1 axis that plays a critical role in alleviating HF-MSCs senescence and apoptosis. We provide a new perspective on the mechanisms underlying stem cell senescence as well as age-related disease prevention and treatment.
Graphical Abstract
Association Between Circulating CD4+ T Cell Methylation Signatures of Network-Oriented SOCS3 Gene and Hemodynamics in Patients Suffering Pulmonary Arterial Hypertension
Authors: Benincasa Giuditta , Maron Bradley A. , Affinito Ornella , D’Alto Michele , Franzese Monica , Argiento Paola , Schiano Concetta , Romeo Emanuele , Bontempo Paola , Golino Paolo , Berrino Liberato , Loscalzo Joseph , Napoli Claudio 
Published: August 2022

AbstractPathogenic DNA methylation changes may be involved in pulmonary arterial hypertension (PAH) onset and its progression, but there is no data on potential associations with patient-derived hemodynamic parameters. The reduced representation bisulfite sequencing (RRBS) platform identified N = 631 differentially methylated CpG sites which annotated to N = 408 genes (DMGs) in circulating CD4+ T cells isolated from PAH patients vs. healthy controls (CTRLs). A promoter-restricted network analysis established the PAH subnetwork that included 5 hub DMGs (SOCS3, GNAS, ITGAL, NCOR2, NFIC) and 5 non-hub DMGs (NR4A2, GRM2, PGK1, STMN1, LIMS2). The functional analysis revealed that the SOCS3 gene was the most recurrent among the top ten significant pathways enriching the PAH subnetwork, including the growth hormone receptor and the interleukin-6 signaling. Correlation analysis showed that the promoter methylation levels of each network-oriented DMG were associated individually with hemodynamic parameters. In particular, SOCS3 hypomethylation was negatively associated with right atrial pressure (RAP) and positively associated with cardiac index (CI) (|r|≥ 0.6). A significant upregulation of the SOCS3, ITGAL, NFIC, NCOR2, and PGK1 mRNA levels (qRT-PCR) in peripheral blood mononuclear cells from PAH patients vs. CTRLs was found (P ≤ 0.05). By immunoblotting, a significant upregulation of the SOCS3 protein was confirmed in PAH patients vs. CTRLs (P < 0.01). This is the first network-oriented study which integrates circulating CD4+ T cell DNA methylation signatures, hemodynamic parameters, and validation experiments in PAH patients at first diagnosis or early follow-up. Our data suggests that SOCS3 gene might be involved in PAH pathogenesis and serve as potential prognostic biomarker.
Graphical abstract
Advancing the cybersecurity of the healthcare system with self-optimising and self-adaptative artificial intelligence (part 2)
Authors: Radanliev Petar , De Roure David 
Published: August 2022

AbstractThis article advances the knowledge on teaching and training new artificial intelligence algorithms, for securing, preparing, and adapting the healthcare system to cope with future pandemics. The core objective is to develop a concept healthcare system supported by autonomous artificial intelligence that can use edge health devices with real-time data. The article constructs two case scenarios for applying cybersecurity with autonomous artificial intelligence for (1) self-optimising predictive cyber risk analytics of failures in healthcare systems during a Disease X event (i.e., undefined future pandemic), and (2) self-adaptive forecasting of medical production and supply chain bottlenecks during future pandemics. To construct the two testing scenarios, the article uses the case of Covid-19 to synthesise data for the algorithms – i.e., for optimising and securing digital healthcare systems in anticipation of Disease X. The testing scenarios are built to tackle the logistical challenges and disruption of complex production and supply chains for vaccine distribution with optimisation algorithms.
Renoprotective activity of anethole- rich fraction from aromatic herbs on junk food induced diabetic nephropathy in rats
Authors: Vellapandian Chitra , R Rini , Ramachandram Dinesh Sangarran 
Published: August 2022

Abstract
Purpose
This study was carried out to study the effect of anethole rich fraction on the Diabetic Nephropathy (DN) rats, and explore the mechanisms.

Methods
Male wistar rats were grouped into 4 (n = 6 per group): Control, junk food fed DN induced rats, low dose and high dose groups. DN was induced by oral junk food feeding. They were monitored for blood glucose levels and urine protein content at regular intervals. At the end of the study, the biological and hematological parameters were measured. Pancreatic and kidney viscera were taken to observe histopathological changes.

Results
Both the doses of anethole rich fraction could drastically lower blood glucose levels, Low Density Lipoprotein (LDL), Glycated Serum Protein (GSP), Total Cholesterol (TC), Triglycerides (TG) (P < 0.01), Malondialdehyde (MDA) level (P < 0.01 or P < 0.05), increases insulin level (P < 0.01), High Density Lipoproteins (HDL), Glutathione Reductase (GSH) and Superoxide Dismutase (SOD) (P < 0.01 or P < 0.05 or P > 0.05). Both doses of anethole rich fraction also improved the pathological changes of kidney and pancreatic tissues in DN rats (P < 0.01 or P < 0.05 or P > 0.05).

Conclusions
Hence it can be hypothesized that the high dose of anethole rich fraction (100 mg/kg) could reach the intervention effect and could ameliorate renal damage in DN rats by improving the renal functions, oxidative stress levels, glycometabolism and pathological changes of pancreas and kidney.
Two remarks on Narkiewicz’s property (P)
Authors: Pottmeyer Lukas 
Published: August 2022

AbstractDue to Narkiewicz a field F has property (P) if for no polynomial $$f\in F[x]$$

f
∈
F
[
x
]

of degree at least two there is an infinite f-invariant subset of F. We present a new example of an algebraic extension of $${\mathbb {Q}}$$
Q
satisfying (P). This is the first example in which we can find points of arbitrarily small positive Weil-height. Moreover, we study the possibility of property (P) for the field generated by all symmetric Galois extensions of $${\mathbb {Q}}$$
Q
. In particular we prove that there are no infinite backward orbits of non linear polynomials in this field.
Generic error bounds for the generalized Lasso with sub-exponential data
Authors: Genzel Martin , Kipp Christian 
Published: August 2022

AbstractThis work performs a non-asymptotic analysis of the generalized Lasso under the assumption of sub-exponential data. Our main results continue recent research on the benchmark case of (sub-)Gaussian sample distributions and thereby explore what conclusions are still valid when going beyond. While many statistical features remain unaffected (e.g., consistency and error decay rates), the key difference becomes manifested in how the complexity of the hypothesis set is measured. It turns out that the estimation error can be controlled by means of two complexity parameters that arise naturally from a generic-chaining-based proof strategy. The output model can be non-realizable, while the only requirement for the input vector is a generic concentration inequality of Bernstein-type, which can be implemented for a variety of sub-exponential distributions. This abstract approach allows us to reproduce, unify, and extend previously known guarantees for the generalized Lasso. In particular, we present applications to semi-parametric output models and phase retrieval via the lifted Lasso. Moreover, our findings are discussed in the context of sparse recovery and high-dimensional estimation problems.
Enrichment of bacteria involved in the nitrogen cycle and plant growth promotion in soil by sclerotia of rice sheath blight fungus
Authors: Mehmood Mirza Abid , Fu Yanping , Zhao Huizhang , Cheng Jiasen , Xie Jiatao , Jiang Daohong 
Published: August 2022

AbstractRice sheath blight pathogen, Rhizoctonia solani, produces numerous sclerotia to overwinter. As a rich source of nutrients in the soil, sclerotia may lead to the change of soil microbiota. For this purpose, we amended the sclerotia of R. solani in soil and analyzed the changes in bacterial microbiota within the soil at different time points. At the phyla level, Proteobacteria, Acidobacteria, Bacteroidetes, Actinobacteria, Chloroflexi and Firmicutes showed varied abundance in the amended soil samples compared to those in the control. An increased abundance of ammonia-oxidizing bacterium (AOB) Nitrosospira and Nitrite oxidizing bacteria (NOB) i.e., Nitrospira was observed, where the latter is reportedly involved in the nitrifier denitrification. Moreover, Thiobacillus, Gemmatimonas, Anaeromyxobacter and Geobacter, the vital players in denitrification, N2O reduction and reductive nitrogen transformation, respectively, depicted enhanced abundance in R. solani sclerotia-amended samples. Furthermore, asymbiotic nitrogen-fixing bacteria, notably, Azotobacter as well as Microvirga and Phenylobacterium with nitrogen-fixing potential also enriched in the amended samples compared to the control. Plant growth promoting bacteria, such as Kribbella, Chitinophaga and Flavisolibacter also enriched in the sclerotia-amended soil. As per our knowledge, this study is of its kind where pathogenic fungal sclerotia activated microbes with a potential role in N transformation and provided clues about the ecological functions of R. solani sclerotia on the stimulation of bacterial genera involved in different processes of N-cycle within the soil in the absence of host plants.
Lesions in White Matter in Wilson’s Disease and Correlation with Clinical Characteristics
Authors: Wang Anqin , Wei Taohua , Wu Hongli , Yang Yulong , Ding Yufeng , Wang Yi , Zhang Chuanfeng , Yang Wenming 
Published: August 2022

ABSTRACT:Background:Neuroimaging studies in Wilson’s disease (WD) have identified various alterations in white matter (WM) microstructural organization. However, it remains unclear whether these alterations are localized to specific regions of fiber tracts, and what diagnostic value they might have. The purpose of this study is to explore the spatial profile of WM abnormalities along defined fiber tracts in WD and its clinical relevance.Methods:Ninety-nine patients with WD (62 men and 37 women) and 91 age- and sex-matched controls (59 men and 32 women) were recruited to take part in experiments of diffusion-weighted imaging with 64 gradient vectors. The data were calculated by FMRIB Software Library (FSL) software and Automated Fiber Quantification (AFQ) software. After registration, patient groups and normal groups were compared by Mann–Whitney U test analysis.Results:Compared with the controls, the patients with WD showed widespread fractional anisotropy reduction and mean diffusivity, radial diffusivity elevation of identified fiber tracts. Significant correlations between diffusion tensor imaging (DTI) parameters and the neurological Unified Wilson’s Disease Rating Scale (UWDRS-N), serum ceruloplasmin, and 24-h urinary copper excretion were found.Conclusions:The present study has provided evidence that the metrics of DTI could be utilized as a potential biomarker of neuropathological symptoms in WD. Damage to the microstructure of callosum forceps and corticospinal tract may be involved in the pathophysiological process of neurological symptoms in WD patients, such as gait and balance disturbances, involuntary movements, dysphagia, and autonomic dysfunction.
Nonclassical Probability, Convex Hulls, and Dutch Books
Authors: Gil Sanchez Michał , Gyenis Zalán , Wroński Leszek 
Published: August 2022

AbstractWe report a solution to an open problem regarding the axiomatization of the convex hull of a type of nonclassical evaluations. We then investigate the meaning of this result for the larger context of the relation between rational credence functions and nonclassical probability. We claim that the notions of bets and Dutch Books typically employed in formal epistemology are of doubtful use outside the realm of classical logic, eventually proposing two novel ways of understanding Dutch Books in nonclassical settings.
Hegel and Formal Idealism
Authors: Oza Manish 
Published: August 2022

Abstract
I offer a new reconstruction of Hegel's criticism of Kant's idealism. Kant held that we impose categorial form on experience, while sensation provides its matter. Hegel argues that the matter we receive cannot guide our imposition of form on it. Contra recent interpretations, Hegel's argument does not depend on a conceptualist account of perception or a view of the categories as empirically conditioned. His objection is that, given Kant's dualistic metaphysics, the categories cannot have material conditions for correct application. This leads to subjectivism in the content of experience: the subject is given an implausibly strong role in determining what is the case. Hegel's own absolute idealism solves this problem.
IoT-enabled product development method to support rapid manufacturing using a nature-inspired algorithm
Authors: Chen Yu , Hao Shengbin , Nazif Habibeh 
Published: August 2022

AbstractInvestigations illustrate that the Internet of Things (IoT) can save costs, increase efficiency, improve quality, and provide data-driven preventative maintenance services. Intelligent sensors, dependable connectivity, and complete integration are essential for gathering real-time information. IoT develops home appliances for improved customer satisfaction, personalization, and enhanced big data analytics as a crucial Industry 4.0 enabler. Because the product design process is an important part of controlling manufacturing, there are constant attempts to improve and minimize product design time. Utilizing a hybrid algorithm, this research provides a novel method to schedule design products in production management systems to optimize energy usage and design time (combined particle optimization algorithm and shuffled frog leaping algorithm). The issue with particle optimization algorithms is that they might become stuck in local optimization and take a long time to converge to global optimization. The strength of the combined frog leaping algorithm local searching has been exploited to solve these difficulties. The MATLAB programming tool is used to simulate the suggested technique. The simulation findings were examined from three perspectives: energy usage, manufacturing time, and product design time. According to the findings, the recommended strategy performed better in minimizing energy use and product design time. These findings also suggest that the proposed strategy has a higher degree of convergence when discovering optimal solutions.
IDEAL OPERATORS AND HIGHER INDESCRIBABILITY
Authors: CODY BRENT , HOLY PETER 
Published: August 2022

AbstractWe investigate properties of the ineffability and the Ramsey operator, and a common generalization of those that was introduced by the second author, with respect to higher indescribability, as introduced by the first author. This extends earlier investigations on the ineffability operator by James Baumgartner, and on the Ramsey operator by Qi Feng, by Philip Welch et al., and by the first author.
Predictors of problematic adult alcohol, cannabis, and other substance use: A longitudinal study of two samples
Authors: Lansford Jennifer E. , Goulter Natalie , Godwin Jennifer , McMahon Robert J. , Dodge Kenneth A. , Crowley Max , Pettit Gregory S. , Bates John E. , Lochman John E. 
Published: August 2022

AbstractThis study examined whether a key set of adolescent and early adulthood risk factors predicts problematic alcohol, cannabis, and other substance use in established adulthood. Two independent samples from the Child Development Project (CDP; n = 585; 48% girls; 81% White, 17% Black, 2% other race/ethnicity) and Fast Track (FT; n = 463; 45% girls; 52% White, 43% Black, 5% other race/ethnicity) were recruited in childhood and followed through age 34 (CDP) or 32 (FT). Predictors of substance use were assessed in adolescence based on adolescent and parent reports and in early adulthood based on adult self-reports. Adults reported their own problematic substance use in established adulthood. In both samples, more risk factors from adolescence and early adulthood predicted problematic alcohol use in established adulthood (compared to problematic cannabis use and other substance use). Externalizing behaviors and prior substance use in early adulthood were consistent predictors of problematic alcohol and cannabis misuse in established adulthood across samples; other predictors were specific to the sample and type of substance misuse. Prevention efforts might benefit from tailoring to address risk factors for specific substances, but prioritizing prevention of externalizing behaviors holds promise for preventing both alcohol and cannabis misuse in established adulthood.
A wideband metamaterial linear to linear conversion for X-band applications
Authors: Gupta Neelesh Kumar , Shukla Pavan Kumar , Pushpalata  
Published: August 2022

AbstractThis article presents wideband metamaterial cross-polarizer (MCP) structure for X-band applications. The proposed MCP consists of a splitted square-shaped resonating structure with two inner and one outer stub. It has an overall dimension of 8.6 mm × 8.6 mm. A wideband polarization conversion ratio (PCR) above 0.87 magnitude is achieved with a bandwidth of 3.49 GHz ranging from 8.8 to 12.29 GHz, which works for X (8–12 GHz) band. The PCR bandwidth of full width half maxima achieved is 4.55 GHz ranging from 8.5 to 13.05 GHz. Two distinct PCR peaks are observed at 9.44 and 11.47 GHz with PCR magnitude at 99.39 and 99.00% respectively. The normalized impedance and electromagnetic parameters (real and imaginary) curves proved the presence of metamaterial properties in the region of interest. Analysis of polarization conversion phenomena at two distinct frequencies is described with the help of electric field and current distribution. The structure is replicated using ANSYS HFSS 19.1 and measured inside anechoic chamber with the help of Vector Network Analyzer (VNA). The replicated and experimented responses obtained are almost similar to one another with adaptation due to fabrication liberality.