bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of temperature indices of silicates
Authors: Khan Abdul Rauf , Ghani Muhammad Usman , Ghaffar Abdul , Asif Hafiz Muhammad , Inc Mustafa 
Published: November 2022

Abstract
A topological index is a numerical value that describes the entire structure of a chemical compound’s molecular graph and aids in the understanding of its physical properties, chemical reactivities, and boiling activities. In chemical graph theory, these indices are instrumental in quantifying various chemical properties of chemical compounds such as SiO4. The selection of SiO4 in this work is an important aspect because of its structural flexibility, easy availability, and extraordinary nature to find its numerical values. In this paper, we compute systematically the first and second temperature, hyper temperature indices, the sum connectivity temperature index, the product connectivity temperature index, the reciprocal product connectivity temperature index, and the F temperature index of a molecular graph SiO4 embedded in a chain. All of the discussed interlinked networks in this manuscript are well motivated by the molecular structure of SiO4.
2020 AMS Mathematics Subject Classification: 05C07, 05C09, 05C31, 05C76, 05C99
Integrative metabolome and transcriptome analyses reveal the regulatory network of ginsenoside synthesis in ginseng
Authors: Wang Huaying , Zhou Xinteng , Fang Xiaoxue , Tian Yibo , Yu Mengfei , Xiao Hongxing 
Published: November 2022

Abstract
Background: Ginsenoside is a vital component of ginseng, which has value in many important medical areas. However, the metabolic kinetics and underlying regulatory networks that regulate ginsenoside synthesis remain largely unknown.
Results: In this study, ginsenoside-associated metabolism and transcriptome data from the roots, stems, and leaves of ginseng with different growth years (1-year-old, 3-year-old, 5-year-old, and 6-year-old) were used to explore the regulatory mechanism of ginsenoside synthesis. We found thatthe content of ginsenosides increased with growth years in root tissues and decreased in stems and leaves, and the content in leaves was always much higher than the contentin roots and stems. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis indicated that differentially expressed genes (DEGs) in all groups were enriched primarily in the mitogen-activated protein kinase (MAPK) signaling pathway-plant, adenosine triphosphate (ATP)-binding cassette (ABC) transporters, and sesquiterpenoid and triterpenoid biosynthesis pathways. Moreover, some genes involved in ginsenoside synthesis were identified as differential alternative splicing genes (DASGs) in differentginseng growth years. In addition, weighted gene coexpression network analysis (WGCNA) was used to generate a coexpression network map that included a number of transcription factors (TFs) (such as WRKY, MYB, and ERF) and enzymes (such as UDP-glycosyltransferases (UGTs), hydroxymethylglutaryl-coenzyme A (CoA) reductase (HMGCR), and squalene epoxidase (SQE)) in the ginsenoside metabolism pathway.
Conclusions: These findings articulate the regulatory network of ginsenoside biosynthesis from the perspectives of the metabolome and transcriptome andlay a foundation for the improved control of gene expression related to ginsenoside synthesis and the content of ginsenosides in ginseng.
A Novel Design for an Ultracompact Optical Majority Gate based on Ring Resonator on Photonic Crystals Substrate
Authors: Parandin Fariborz , Sheykhian Arezoo , Bagheri Nila 
Published: November 2022

Abstract
This paper tries to design and simulate a majority gate with three inputs based on the resonance ring of 2D photonic crystals. In the design of this gate, a resonator gate and 4 waveguides in a square lattice have been used. This structure is simple and small with dielectric rods of silicon on an air substrate. Low and high logics are defined based on the optical sources being on or off. The large interval between 0 and 1 at the output demonstrates high accuracy of this optical gate. The operating wavelength of this optical majority gate is 1.55µm, which is in the photonic band-gap calculated for the gate structure. Calculations are carried out in the TM mode using the FDTD numerical method.
Profiling of eccDNAs in Arabidopsis indicates shift in population of TE-derived eccDNAs in response to stress, cellular state,and epigenetic processes
Authors: Vanderschuren Herve , Zaidi Syed Shan-e-Ali , Shakir Sara , Mehta Devang , Nguyen Vu , Gutzat Ruben 
Published: November 2022

Abstract
Evidence for the existence of extrachromosomal circular DNA (eccDNA) was presented decades ago, but only recent technological advancements have allowed a better characterization of eccDNA, including their crucial role in human pathogenesis, which is to increase the copy number and availability of oncogenes. However, the current eccDNA studies are based on short-read sequencing technologies and have limitations in accessing the integrity and abundance of eccDNA populations. Here we provide the eccDNA profiles and the landscape of active transposons in various Arabidopsis tissues, including meristematic cells sorted by fluorescence-activated nuclei, using high-accuracy long-read circular consensus sequencing. Comparative analysis of eccDNA profiles in actively dividing tissues and heat-stressed seedlings was also instrumental to identify known and previously unknown eccDNA-active loci. In-depth analysis of eccDNAs originating from ONSEN loci indicated preferential mobilization from young transposon loci. Our dataset also identified eccDNAs generated from loci of the superfamily RC/Helitrons as the most abundant eccDNAs in Arabidopsis. Profiling of eccDNA populations in selected Arabidopsis mutants of the DNA methylation pathways revealed that eccDNA formation from several retrotransposon loci is induced in the absence of active DNA demethylase ROS1. Together, these eccDNA datasets provide a useful plant genomics resource with the identification of eccDNA-active genomic loci that could help advancing our understanding of eccDNA biogenesis and functions in eukaryotes.
Impact of an online decision aid for risk-stratified breast screening on understanding, acceptance and decision-making: results of a pre-post survey design study.
Authors: Forrest Laura , Lippey Jocelyn , Keogh Louise , Mann G. Bruce , Campbell Ian 
Published: November 2022

Abstract
Background: Internationally, population breast cancer screening is moving towards a risk-stratified approach and requires engagement and acceptance from current and future screening clients. A decision aid (www.defineau.org) was developed based on women’s views, values, and knowledge regarding risk-stratified breast cancer screening. This study aims to evaluate the impact of the decision aid on women’s knowledge, risk perception, acceptance of risk assessment and change of screening frequency, and decision-making.
Methods: Women who are clients of BreastScreen Victoria were invited to complete an online questionnaire before and after viewing the decision aid.
Results: 3200 potential participants were invited, 242 responded with 127 participants completing both surveys. After reviewing the decision aid there was a significant change in knowledge, acceptance of risk stratified breast cancer screening and of decreased frequency screening for lower risk. High levels of acceptance of risk stratification, genetic testing and broad support for tailored screening persisted pre and post review.
Conclusions: The DEFINE decision aid had a positive impact on accepting lower frequency screening, a major barrier to the success of a risk-stratified program and may contribute to facilitating change to the population breast screening program in Australia.
Implementation of virtual reality in healthcare: a scoping review on the implementation process of virtual reality in various healthcare settings
Authors: Kouijzer Marileen , Kip Hanneke , Bouman Yvonne H.A. , Kelders Saskia M. 
Published: November 2022

Abstract
Background
Despite the potential added value of virtual reality technology in healthcare, its uptake in clinical practice is still in its infancy and challenges arise in the implementation of VR. Effective implementation could improve the adoption, uptake, and impact of VR. However, these implementation procedures still seem to be understudied in practice. This scoping review aimed to examine the current state of affairs in the implementation of VR technology in healthcare settings and to provide an overview of factors related to the implementation of VR.
Methods
To give an overview of relevant literature, a scoping review was undertaken of articles published up until February 2022, guided by the methodological framework of Arksey and O’Malley (2005). The databases Scopus, PsycINFO, and Web of Science were systematically searched to identify records that highlighted the current state of affairs regarding the implementation of virtual reality in healthcare settings. Information about each study was extracted using a structured data extraction form.
Results
Of the 5523 records identified, 29 were included in this study. Most studies focused on barriers and facilitators to implementation, that highlight similar factors related to the behavior of adopters of VR and the practical resources that the organization should arrange for. However, few studies focus on systematic implementation and on using a theoretical framework to guide implementation. Despite the recommendation of using a structured, multi-level implementation intervention to support the needs of all involved stakeholders, there was no link between the identified barriers and facilitators, and concrete implementation objectives or suitable strategies to overcome these barriers in the included articles.
Conclusion
To take the implementation of VR in healthcare to the next level, it is important to ensure that implementation is not studied in separate studies focusing on one element, e.g., caregiver-related barriers, as is common in current literature. Based on the results of this study, we recommend that the implementation of VR entails the entire process, from identifying barriers to developing and employing a coherent, multi-level implementation intervention with suitable strategies. This implementation process could be supported by implementation frameworks, and ideally focus on behavior change of stakeholders such as caregivers, patients, and managers. This in turn might result in increased uptake and use of VR technologies that are of added value for healthcare practice.
Computational and Electrochemical Study of Pyrantel as Alternative Green Corrosion Inhibitor of S275JR Mild Steel and 1100-H14 Aluminum Alloys in H2SO4 Acidic Environment
Authors: Ugi Benedict , Nandi Desmond Obi 
Published: November 2022

Abstract
The study on Recycling and application of Pyrantel as alternative corrosion inhibitor of S275JR mild steel and 1100-H14 aluminum alloys in 1 M H2SO4 acid environment was investigated adopting different experimental methods including weight loss, hydrogen evolution (gasometric), electrochemical impedance spectroscopic, potentiodynamic polarization and computational (quantum chemical calculations and molecular dynamic simulation) methods It was observed that pyrantel was a good inhibitor for both metals but with more inhibition on the 1100-H14 – type aluminum. Inhibition efficiency was recorded between 42.5% and 95.2% for aluminum at concentrations of 500 ppm and 1500 ppm respectively while 30.0% and 72.5% was recorded for S275JR mild steel at same concentrations as aluminum. This high inhibition efficient was attributed to the strong adsorption of the molecules on both metal surfaces. This result was in agreement with those of gasometric experiment. Electrochemical impedance showed higher and increasing values of charge transfer resistance and decreasing values for the double layer capacitance which indicated a better inhibition. From quantum calculations, the EHOMO values was higher than that of the ELUMO while the energy gap was calculated to be 1.9 with binding energy of 132.9. An indication that absorption was very strong and pyrantel is a good inhibitor. The data were in agreement with Langmuir adsorption isotherm as the correlation coefficient values were approximately unity indicating a physical adsorption and hence adsorption consists entirely of a monolayer at the surface.
Downstream STING pathways IRF3 and NF-κB differentially regulate CCL22 in response to cytosolic dsDNA
Authors: Kim Jihyun , Pena Jocelyn V. , McQueen Hannah P. , Kong Lingwei , Lomashvili Elmira M. , Michael Dina , Cook Pamela R. 
Published: November 2022

Abstract
Double-stranded DNA (dsDNA) in the cytoplasm of eukaryotic cells is abnormal and typically indicates the presence of pathogens or mislocalized self-DNA. Multiple sensors detect cytosolic dsDNA and trigger robust immune responses via activation of type I interferons. Several cancer immunotherapy treatments also activate cytosolic nucleic acid sensing pathways, including oncolytic viruses, nucleic acid-based cancer vaccines, and pharmacological agonists. We report here that cytosolic dsDNA introduced into malignant cells can robustly upregulate expression of CCL22, a chemokine responsible for the recruitment of regulatory T cells (Tregs). Tregs in the tumor microenvironment are thought to repress anti-tumor immune responses and contribute to tumor immune evasion. Surprisingly, we found that CCL22 upregulation by dsDNA was mediated primarily by interferon regulatory factor 3 (IRF3), a key transcription factor that activates type I interferons. This finding was unexpected given previous reports that type I interferon alpha inhibits CCL22 and that IRF3 is associated with strong anti-tumor immune responses, not Treg recruitment. We also found that CCL22 upregulation by dsDNA occurred concurrently with IFN-β upregulation. IRF3 is one of two transcription factors downstream of the STimulator of INterferon Genes (STING), which is a hub adaptor protein through which many different dsDNA sensors transmit their signals. The other transcription factor downstream of STING, NF-κB, has been reported to regulate CCL22 expression in other contexts, and NF-κB has been ascribed multiple pro-tumor functions, including Treg recruitment. However, we found that NF-κB in the context of activation by cytosolic dsDNA contributed minimally to CCL22 upregulation compared with IRF3. Lastly, we observed that two strains of the same cell line differed profoundly in their capacity to upregulate CCL22 and IFN-β in response to dsDNA, despite apparent STING activation in both cell lines. This finding suggests that during tumor evolution, cells can acquire, or lose, the ability to upregulate CCL22. This study adds to our understanding of factors that may modulate immune activation in response to cytosolic DNA and has implications for immunotherapy strategies that activate DNA sensing pathways in cancer cells.
Decreasing relative importance of drawdown areas on waters in CO2 emissions in drylands
Authors: Ma Yuanzhi , Ling Hongbo , Deng Xiaoya , Han Feifei , Li Fujie , Yan Junjie , Gong Yanming , Zhang Guangpeng , Shan Qianjuan , Kang Ziwei , Jiao Ayong 
Published: November 2022

Abstract
Previous studies have mostly focused on the annual CO2 emissions from drawdown areas on a global scale. However, in drylands, which are more sensitive to global change, finely characterizing the relative importance of drawdown areas on waters (RIDW) in CO2 emissions at the spatio-temporal scale remains unclear. Here, we found that the total drawdown area of drylands could reach 22% of the waters area. From 2004 to 2020, the shrinking of the drawdown area of temperate lakes and reservoirs was the main factor leading to the decline of the total drawdown area. As a result, the mean total CO2 emissions from drawdown areas during 2013-2020 decreased by 18% compared with 2004-2012. The expansion of waters area led to a 29% increase in CO2 emissions from waters. The mean annual CO2 emissions from drawdown areas in drylands was as high as 132.3 ± 23.1 Tg C yr-1, which is equivalent to 61% of estimated CO2 emissions from waters, but its share of CO2 emissions of non-perennial waters shows a significant downward trend. Our study suggests that the spatio-temporal heterogeneity of CO2 emissions caused by the change of drylands waters area is an important part of the global carbon cycle.
Structural change likely increases inequality in India more than climate policy
Authors: Leimbach Marian , Hübler Michael , Mahlkow Hendrik , Montrone Lorenzo , Bukin Eduard , Felbermayr Gabriel , Kalkuhl Matthias , Koch Johannes , Marcolino Marcos , Pothen Frank , Steckel Jan 
Published: November 2022

Abstract

The decarbonization of India’s economy will affect economic actors differently. Here we study the distributional effects of climate policy in India, taking the specific role of structural economic change into account. We contrast distributional effects from climate policy with distributional effects from structural change and quantify how far carbon pricing supports structural change and economic development. We develop and apply a comprehensive model framework that combines long-term growth and medium-term trade dynamics related to structural change with detailed household income and expenditure data for India. Our results emphasize that distributional effects from structural change are stronger than from carbon pricing. Consequently, governments should not focus solely on the distributional effects of climate policy, but also consider the larger context of economic transformation processes when designing and implementing social policies.
A Systematic Review on a comprehensive evaluation of clinical prognostic variables and new biomarkers for head and neck cancer outcome
Authors: Sreeku Vinod Nair , Madhulaxmi Marimuthu , Ankathil Ravindran , Arumugham Paramasivam 
Published: November 2022

Abstract
All patients with the same TNM stage are treated according to the current algorithms for the clinical treatment of patients with head and neck squamous cell carcinoma (HNSCC). Patient outcomes can be considerably improved by choosing a therapy based on a patient's unique distinctions in the genetic and biological properties of the tumour. Rapid technology advancements that enable thorough molecular characterisation of malignancies quickly and affordably have improved our understanding of the molecular pathways involved in tumour transformation and HNSCC disease development. Mining genetic data to enhance tumour staging, prognosis, and personalised therapy choices for HNSCC patients has not yet become standard practice despite noteworthy accomplishments in other tumour forms. We analyse and summarise both old and new data on predictive biomarkers for HNSCC in this review, intending to potentially enhance clinical patient care shortly.
Cross-cultural adaptation of the Job Insecurity Scale (JIS) in Brazil and cross-national analysis of Job Insecurity effects in Brazil and Spain
Authors: Llosa José Antonio , Agulló-Tomás Esteban , Menéndez-Espina Sara , Heleno Camila Teixeira , Borges Livia de Olivera 
Published: November 2022

Abstract
Background: Job flexibilisation has increased interest in job insecurity and its consequences. Job insecurity, understood as a fear of losing employment, is linked to a deterioration of mental health, social relations or job satisfaction. Its study has been developed primarily in Europe, in the absence of validated psychometric scales in the Latin American context. To bridge this knowledge gap, the aim of this study is to cross-culturally adapt the Job Insecurity Scale (JIS) in Brazil, and secondly, to establish a cross-national analysis between people employed in Brazil and Spain.
Methods: 1,165 employed people participate in the study, of whom 573 reside in Brazil and 592 in Spain. For the scale adaptation process, a sequence of EFA, CFA and validity tests are carried out, as well as a multigroup invariance according to the gender variable. The cross-national comparison compares the effect sizes of affective and cognitive job insecurity on the mental health variable measured with the GHQ-28 scale in both countries.
Results: The results of the scale adaptation show that the JIS is suitable for use in the Brazilian employment context, offering a factorialisation in two dimensions (affective and cognitive) with good reliability (ω> . 84). The cross-national comparison shows that job insecurity has a greater weight in explaining the mental health of the employed population in Brazil than in Spain, which is related to higher indicators of job insecurity in the Brazilian context.
Conclusions: With this validation we now have a validated scale of job insecurity validated for the Brazilian context. The comparison between countries shows the need to establish these analyses, since the behaviour of the phenomenon is different in the contexts studied.
Pan-cancer analysis of whole-genome doubling and its association with patient prognosis
Authors: Kikutake Chie , Suyama Mikita 
Published: November 2022

Abstract

Background Whole-genome doubling (WGD) is a common mutation in cancer. Various studies suggested that WGD is associated with a poor prognosis in cancer. However, the detailed association between WGD occurrence and prognosis remains unclear. In this study, we aimed to elucidate how WGD affects prognosis using sequencing data from the Pan-Cancer Analysis of Whole Genomes and The Cancer Genome Atlas. Methods Whole-genome sequencing data of 23 cancer types were downloaded from the PanCancer Analysis of Whole Genomes (PCAWG) project. We defined the WGD event in each sample using the WGD status annotated by the PCAWG. We used MutationTimeR to predict the relative timing of mutations and LOH to WGD, which were investigated the association with WGD and them. We also analyzed the association between the WGD-associated factors and patient prognosis. Results We detected that WGD is associated with several factors, e.g., loss of heterozygosity (LOH) length. Survival analysis using WGD-associated factors showed that longer LOH and LOH in chr17 were associated with poor prognosis in the samples with and without WGD. In addition to these two factors, samples without WGD showed that the number of mutations in tumor suppressor genes was associated with prognosis. Moreover, we explored genes associated with prognosis in both samples separately. Conclusion This study revealed that the prognosis-related factors in samples with and without WGD significantly differ. This study emphasizes the need for different treatment strategies for samples with and without WGD.
Influence of a prolonged shelf time on PA12 laser sintering powder and resulting part properties
Authors: Klippstein Sven Helge , Kletetzka Ivo , Sural Ilknur , Schmid Hans-Joachim 
Published: November 2022

Abstract
In the laser sintering technology, the material is exposed to elevated temperatures during processing, leading to serious material ageing . This has already been investigated intensively by various authors,.However, the ageing of the material at ambient temperatures as during shelf life has not been in the focus so far. The need to analyze the shelf life can be derived from an ecological and economic point of view. This work is focusing on the shelf life of PA2200 (PA12). To reduce potential influences of powder production fluctuations, two different powder batches stored for 5.5 years and 6.5 years are investigated and compared to a reference powder produced 0.5 years before these investigations. Multiple powder analyses and part characterizations have been performed. A significant yellowing and molecular chain length reduction can be derived from the measurement results. Whereas the influence on mechanical part performance was minor, the parts built with the stored powders are more yellowish. As it is most likely, that this is due to the consumption of the polyamide stabilizers, it can be assumed that these parts will be subject to significantly faster ageing. Therefore, it is still not recommended to use the stored powders for critical parts or light intense and humid environments.