bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different Coefficients for Studying Dependence
Authors: Rainio Oona 
Published: September 2022

AbstractThrough computer simulations, we research several different measures of dependence, including Pearson’s and Spearman’s correlation coefficients, the maximal correlation, the distance correlation, a function of the mutual information called the information coefficient of correlation, and the maximal information coefficient (MIC). We compare how well these coefficients fulfill the criteria of generality, power, and equitability. Furthermore, we consider how the exact type of dependence, the amount of noise and the number of observations affect their performance. According to our results, the maximal correlation is often the best choice of these measures of dependence because it can recognize both functional and non-functional types of dependence, fulfills a certain definition of equitability relatively well, and has very high statistical power when the noise grows if there are enough observations. While Pearson’s correlation does not find symmetric non-monotonic dependence, it has the highest statistical power for recognizing linear and non-linear but monotonic dependence. The MIC is very sensitive to the noise and therefore has the weakest statistical power.
Physicochemical properties of imported and locally produced honey did not translate into its microbial quality and antibacterial activity
Authors: Nzeh Joseph , Quansah Lydia , Dufailu Osman Adamu 
Published: September 2022

AbstractHoney is often considered a good substitute for sugar. However, concerns about the poor quality of locally produced honey have necessitated the importation of honey to meet the domestic demand in spite of Ghana’s good climatic conditions suitable for honey production. Due to the increasing level of demand for honey both locally and internationally, we highlighted here the need for an assessment of the physicochemical, microbiological quality, and antibiotics resistance of microbes isolated from the imported and locally produced honey vis-à-vis international standards. Thirty honey samples which comprise 7 imported and 23 locally produced were randomly sampled from retail outlets consisting of supermarkets, marts, shops, and open markets as well as from production sites within the northern region for physicochemical analysis, microbial analysis, and antibiogram. Results of the physicochemical quality analysis showed that sampled honey (both imported and locally produced) was within acceptable set standards. However, microbial quality was poor as a high incidence of bacterial contamination and resistance was recorded in the study. The High incidence of bacterial contamination and antibiotic resistance recorded in this study gives an indication that all is not well in the honey industry and therefore the need for appropriate measures to avert possible health issues associated with the consumption of honey found within the region.
Beyond Death in the <i>Oresteia</i>
Authors: Shilo Amit 
Published: September 2022

The Oresteia is permeated with depictions of the afterlife, which have never been examined together. In this book Amit Shilo analyses their intertwined and conflicting implications. He argues for a 'poetics of multiplicity' and 'poetics of the beyond' that inform the ongoing debates over justice, fate, ethics, and politics in the trilogy. The book presents novel, textually-grounded readings of Cassandra's fate, Clytemnestra's ghost scene, mourning ritual, hero cult, and punishment by Hades. It offers a fresh perspective on the political thought of the trilogy by contrasting the ethical focus of the Erinyes and Hades with Athena's insistence on divine unity and warfare. Shedding new light on the trilogy as a whole, this book is crucial reading for students and scholars of classical literature and religion. This title is available as open access on Cambridge Core.
International access to research infrastructure in the Arctic
Authors: Ruck Kate , Arndal Marie Frost , Biebow Nicole , Dahl Justiina , Flått Stig , Granskog Mats , Holste Svenja , Lenz Josefine , Mercer Jennifer , Pausch Franziska , Perttu Anna-Maria , Rasch Morten , Samuelsson Maria , Sundfjord Arild , Thomas Femi Anna , Topp-Jørgensen Elmer , Willmott Veronica 
Published: September 2022

Abstract
Reliable access to Arctic research infrastructure is critical to the future of polar science. In cultivating proposals, it is essential that researchers have a deep understanding of existing platforms when selecting the appropriate research site and experimental design for projects. However, Arctic infrastructure platforms are often funded as national assets, and choices for what would be the best platform for the project are sometimes at odds with a researcher’s ability to gain access. Researchers from Arctic and non-Arctic nations are poised to benefit from reducing barriers and increasing cooperation around transnational access to Arctic infrastructure, allowing scientists to successfully execute the research that is most needed rather than what is just logistically feasible. This commentary provides a summary of findings from a workshop held at the 2021 Arctic Science Summit Week to discuss navigating “transnational” or “cross-border” access to national research infrastructure. This workshop brought together users and operators of Arctic infrastructure platforms with the three goals of identifying challenges, best practices, and possible next steps for improved collaboration.
Sudden cardiac arrest response preparedness in Durham County schools
Authors: Sooy-Mossey Meredith , DeRusso Michelle , Green Cynthia L. , Best Debra L. 
Published: September 2022

AbstractSudden cardiac arrest is an uncommon event with high morbidity and mortality. There are improved outcomes with early access to an automated external defibrillator and cardiopulmonary resuscitation. We assessed the availability of automated external defibrillators and emergency cardiac arrest plans in schools. A cross-sectional electronic survey was conducted to determine the status of emergency cardiac arrest plans and automated external defibrillator presence. Most schools (88%) had access to an automated external defibrillator; however, trained staff and maintenance plans were highly variable. Automated external defibrillator availability did not differ by racial/ethnic or socio-economic composition; however, there was a relationship between number of automated external defibrillators and student population (p = 0.0030). The majority of schools either did not have (28%) or did not know if they had (36%) an emergency cardiac arrest plan. Even without state legislation, automated external defibrillators were largely available in schools. However, there remains a paucity of emergency cardiac arrest plans and automated external defibrillator maintenance plans.
Extraterrestrial intelligence and moral standing
Authors: Ćirković Milan M. , Katić Ana 
Published: September 2022

AbstractWe consider the Search for ExtraTerrestrial Intelligence (SETI) activities from a bioethical standpoint. In particular, we argue that there is a moral duty to search for other intelligent beings in the Universe. Some of them could – and are likely to be – morally enhanced in the sense that they are not only capable of unmistakable moral reasoning but are also capable of consistently acting upon the results of such deliberations. Even if the probability of finding such morally superior beings is small, it is higher than zero in any case; in fact, our astrobiological knowledge suggests that this probability is significant. Hence, there are both deductive and inductive arguments for the proposition that our duty is to search for such morally superior extraterrestrial beings. In other words, there is a duty to undertake and support our SETI efforts. The argument to that effect runs parallel to some of the arguments deployed in current debates on human moral enhancement.
Effect of varieties and planting dates of bread wheat-lupine intercropping system under additive design in Northwest Ethiopia
Authors: Bayeh Birhanu , Alemayehu Getachew , Tadesse Tilahun , Alemayehu Melkamu 
Published: September 2022

AbstractFood production on ever-dwindling agricultural land is a severe problem in Ethiopia, necessitating the adoption of more efficient and sustainable land-use strategies to feed the country's growing population. The benefits of intercropping are known to be limited by a variety of factors such as companion crop sowing date and variety. The present study was therefore initiated to evaluate the effect of varieties and planting dates of lupines in bread wheat-lupine under an additive design intercropping system in Northwest Ethiopia. Field experiments were conducted for two years in Adet and Debre Tabor experimental sites. The treatments consisted of four planting dates of lupines and two varieties of lupine. Moreover, the sole crop of bread wheat (Triticum aestivumeL.), local lupine (Lupinus albusL.) and sweet lupine (Lupinus angustifloliusL.) were also included. The experiments were laid out in factorial randomized complete block design (RCBD) with three replications. The results showed that at the Adet experimental site, the highest land equivalent ratio (LER) was recorded in the simultaneous planting of sweet lupine and bread wheat (1.3), followed by the planting of sweet lupine two weeks after bread wheat (1.23). While at Debre Tabor experimental site, the highest LER was recorded in planting sweet lupine two weeks after bread wheat (1.67). A greater area time equivalent ratio (ATER) was reported in the simultaneous planting of sweet lupine and bread wheat (1.29), followed by the planting of sweet lupine after bread wheat (1.22) at the Adet experimental site. A greater ATER was also recorded in the planting of sweet lupine after bread wheat (1.53) had the highest ATER in Debre Tabor, followed by simultaneous planting of sweet lupine after bread wheat (1.39) intercropping. This revealed that sole cropping would necessitate 29 and 53% more area, respectively, to attain the same yield as intercropping. In Adet, the simultaneous planting of sweet lupine and bread wheat intercropping, while in Debre Tabor, planting of sweet lupine two weeks after bread wheat boosted productivity, and production efficiency and is a viable option for increasing household food security.
Exploration of Atmosphere‐Only Model Deficiencies in Reproducing the 1992–2011 Pacific Trade Wind Acceleration
Authors: van Rensch Peter , McGregor Shayne , Dommenget Dietmar 
Published: September 2022

AbstractA robust simulation of tropical Pacific Ocean decadal‐scale zonal wind stress trends can increase the confidence in projections of global surface temperature and regional sea level rise, yet coupled general circulation models simulate weaker trends than observed. When forced with observed sea surface temperatures, the atmospheric component of these models still simulates a weaker zonal wind stress trend during 1992–2008 (and 1992–2011) than observed. Yet, this decadal wind trend bias is not evident at the 850 hPa level. We show that the modelled wind trend bias is related to deficiencies in monthly wind stress variability. Furthermore, the strength of the connectivity between the surface and 850 hPa was also an indicator of the wind stress trend. Models that simulated a more realistic wind stress trend tend to simulate a stronger Pacific zonal sea level pressure gradient intensification than observed and a South Pacific Convergence Zone shift like that observed.
Time Variable Stress Inversion of Centroid Moment Tensor Data Using Gaussian Processes
Authors: Okazaki Tomohisa , Fukahata Yukitoshi , Ueda Naonori 
Published: September 2022

AbstractThis study presents a new method of centroid moment tensor (CMT) data inversion to estimate time‐dependent regional stress fields. The Gaussian process (GP) is applied to resolve the computational difficulty of the existing basis function expansion method when analyzing high‐dimensional data, including time dependence. A critical step in the formulation is an analytical derivation of the relationship of the covariance function, which is a key ingredient of GP, between CMT data and the model stress field based on an observation equation. The validity and efficiency of the proposed method are verified through applications to CMT data in and around Japan after the 2011 Tohoku earthquake. The estimated stress field exhibits small‐scale heterogeneity in space and long‐term stability in time for most regions. Additionally, significant temporal variations are observed around the margin of the focal region of the 2011 event, with opposite changes on landward and oceanward sides. GP would be particularly effective for geophysical inversions of high‐dimensional data distributed over a broad region.
An ecological animal model of subthreshold depression in adolescence: behavioral and resting state 18F-FDG PET imaging characterization
Authors: Accrombessi Georgine , Galineau Laurent , Tauber Clovis , Serrière Sophie , Moyer Esteban , Brizard Bruno , Le Guisquet Anne-Marie , Surget Alexandre , Belzung Catherine 
Published: September 2022

AbstractThe different depressive disorders that exist can take root at adolescence. For instance, some functional and structural changes in several brain regions have been observed from adolescence in subjects that display either high vulnerability to depressive symptoms or subthreshold depression. For instance, adolescents with depressive disorder have been shown to exhibit hyperactivity in hippocampus, amygdala and prefrontal cortex as well as volume reductions in hippocampus and amygdala (prefrontal cortex showing more variable results). However, no animal model of adolescent subthreshold depression has been developed so far. Our objective was to design an animal model of adolescent subthreshold depression and to characterize the neural changes associated to this phenotype. For this purpose, we used adolescent Swiss mice that were evaluated on 4 tests assessing cognitive abilities (Morris water maze), anhedonia (sucrose preference), anxiety (open-field) and stress-coping strategies (forced swim test) at postnatal day (PND) 28–35. In order to identify neural alterations associated to behavioral profiles, we assessed brain resting state metabolic activity in vivo using18F-FDG PET imaging at PND 37. We selected three profiles of mice distinguished in a composite Z-score computed from performances in the behavioral tests: High, Intermediate and Low Depressive Risk (HDR, IDR and LDR). Compared to both IDR and LDR, HDR mice were characterized by passive stress-coping behaviors, low cognition and high anhedonia and anxiety and were associated with significant changes of18F-FDG uptakes in several cortical and subcortical areas including prelimbic cortex, infralimbic cortex, nucleus accumbens, amygdala, periaqueductal gray and superior colliculus, all displaying higher metabolic activity, while only the thalamus was associated with lower metabolic activity (compared to IDR). LDR displayed an opposing behavioral phenotype and were associated with significant changes of18F-FDG uptakes in the dorsal striatum and thalamus that both exhibited markedly lower metabolic activity in LDR. In conclusion, our study revealed changes in metabolic activities that can represent neural signatures for behavioral profiles predicting subthreshold depression at adolescence in a mouse model.
Clinical outcomes in patients with chronic lymphocytic leukemia with disease progression on ibrutinib
Authors: Hampel Paul J. , Rabe Kari G. , Call Timothy G. , Ding Wei , Leis Jose F. , Chanan-Khan Asher A. , Kenderian Saad S. , Muchtar Eli , Wang Yucai , Ailawadhi Sikander , Koehler Amber B. , Parrondo Ricardo , Schwager Susan M. , Sher Taimur , Hanson Curtis A. , Shi Min , Van Dyke Daniel L. , Braggio Esteban , Slager Susan L. , Kay Neil E. , Parikh Sameer A. 
Published: September 2022

AbstractPatients with chronic lymphocytic leukemia (CLL) with disease progression on ibrutinib have worse outcomes compared to patients stopping ibrutinib due to toxicity. A better understanding of expected outcomes in these patients is necessary to establish a benchmark for evaluating novel agents currently available and in development. We evaluated outcomes of 144 patients with CLL treated at Mayo Clinic with 2018 iwCLL disease progression on ibrutinib. The median overall survival (OS) for the entire cohort was 25.5 months; it was 29.8 months and 8.3 months among patients with CLL progression (n = 104) and Richter transformation (n = 38), respectively. Longer OS was observed among patients with CLL progression who had received ibrutinib in the frontline compared to relapsed/refractory setting (not reached versus 28.5 months; p = 0.04), but was similar amongst patients treated with 1, 2, or ≥3 prior lines (18.5, 30.9, and 26.0 months, respectively, p = 0.24). Among patients with CLL disease progression on ibrutinib, OS was significantly longer when next-line treatment was chimeric antigen receptor T-cell therapy (median not reached) or venetoclax-based treatment (median 29.8 months) compared to other approved treatments, such as chemoimmunotherapy, phosphoinositide 3’-kinase inhibitors, and anti-CD20 monoclonal antibodies (9.1 months; p = 0.03). These findings suggest an unmet need for this growing patient population.
Identification of two pathways mediating protein targeting from ER to lipid droplets
Authors: Song Jiunn , Mizrak Arda , Lee Chia-Wei , Cicconet Marcelo , Lai Zon Weng , Tang Wei-Chun , Lu Chieh-Han , Mohr Stephanie E. , Farese Robert V. , Walther Tobias C. 
Published: September 2022

AbstractPathways localizing proteins to their sites of action are essential for eukaryotic cell organization and function. Although mechanisms of protein targeting to many organelles have been defined, how proteins, such as metabolic enzymes, target from the endoplasmic reticulum (ER) to cellular lipid droplets (LDs) is poorly understood. Here we identify two distinct pathways for ER-to-LD protein targeting: early targeting at LD formation sites during formation, and late targeting to mature LDs after their formation. Using systematic, unbiased approaches inDrosophilacells, we identified specific membrane-fusion machinery, including regulators, a tether and SNARE proteins, that are required for the late targeting pathway. Components of this fusion machinery localize to LD–ER interfaces and organize at ER exit sites. We identified multiple cargoes for early and late ER-to-LD targeting pathways. Our findings provide a model for how proteins target to LDs from the ER either during LD formation or by protein-catalysed formation of membrane bridges.
Myo-inositol moderates maternal BMI and glycemia related variations in in-vitro placental 13C-DHA-metabolism, altering their relationships with birthweight
Authors: Watkins Oliver C. , Selvam Preben , Pillai Reshma Appukuttan , Cracknell-Hazra Victoria K. B. , Yong Hannah E. J. , Sharma Neha , Cazenave-Gassiot Amaury , Bendt Anne K. , Godfrey Keith M. , Lewis Rohan M. , Wenk Markus R. , Chan Shiao-Yng 
Published: September 2022

AbstractTransplacental docosahexaenoic-acid (DHA) supply for fetal development is regulated by placental DHA-lipid metabolism. Both maternal diabetes and obesity are linked to possible decreased fetal circulating DHA and increased placental DHA-lipids. Since myo-inositol is a promising intervention for gestational diabetes (GDM), we aimed to determine whether myo-inositol could rectify perturbations in placental DHA metabolism associated with maternal increasing glycemia and obesity and examine links with birthweight. Term placental villous explants from 17 women representing a range of BMIs and mid-gestational glycemia, were incubated with 13C-labeled-DHA for 48 h, in 0.3 µmol/L (control) or 60 µmol/L myo-inositol. Individual newly synthesized 13C-DHA-labeled lipid species were quantified by liquid-chromatography-mass-spectrometry. Compared with controls, incubation with myo-inositol decreased most 13C-DHA-lipids in placental explants from women with higher BMI or higher glycemia, but increased 13C-DHA-lipids with normal BMI or lower glycemia. Myo-inositol also increased 13C-DHA-labeled lipids in cases of lower birthweight centile, but induced decreases at higher centiles. Myo-inositol therefore lowered DHA-lipids in placenta with high basal placental DHA-lipid production (higher BMI and glycemia) but increased DHA-lipids where basal processing capacity is low. Myo-inositol thus moderates placental DHA metabolism towards a physiological mean which may in turn moderate birthweight.
Avalanche criticality in LaAlO$$_3$$ and the effect of aspect ratio
Authors: Scott John J. R. , Casals Blai , Luo King-Fa , Haq Atta , Mariotti Davide , Salje Ekhard K. H. , Arredondo Miryam 
Published: September 2022

AbstractFerroic domain dynamics, as a function of external stimuli, can be collectively described as scale-invariant avalanches characterised by a critical exponent that are sensitive to the complexity of the domain microstructure. The understanding and manipulation of these avalanches lies at the heart of developing novel applications such as neuromorphic computing. Here we combine in situ heating optical observations and mean-field analysis to investigate the collective domain behaviour in pure-ferroelastic lanthanum aluminate (LaAlO$$_3$$

3

) as a function of aspect ratio, the ratio of sample length to width, where the movement of the domains is predominantly driven by thermal stresses via thermal expansion/contraction during heat cycling. Our observations demonstrate that the aspect ratio induces (1) distinctive domain microstructures at room temperature, (2) a deviation of dynamical behaviour at high temperatures and (3) critical exponent mixing in the higher aspect ratio samples that accompanies this behaviour. While the critical exponents of each aspect ratio fall within mean-field predicted values, we highlight the effect that the aspect ratio has in inducing exponent mixing. Hence, furthering our understanding towards tuning and controlling avalanches which is crucial for fundamental and applied research.
Comparison of treatment methods for submacular hemorrhage in neovascular age-related macular degeneration: conservative versus active surgical strategy
Authors: Mun Yongseok , Park Kyu Hyung , Park Sang Jun , Cho Han Joo , Kim Chul Gu , Kim Jong Woo , Park Dong Geun , Sagong Min , Kim Jae Hui , Woo Se Joon 
Published: September 2022

AbstractThe optimal treatment of submacular hemorrhage (SMH) following neovascular age-related macular degeneration (nAMD) is controversial. This study aimed to compare visual outcomes of conservative versus active surgical treatment. Two hundred thirty-six eyes of 236 patients with SMH (≥ 1 disc diameter) were stratified into four groups: observation (n = 21); anti-vascular endothelial growth factor (VEGF) monotherapy (n = 161); non-surgical gas tamponade (n = 31); and subretinal surgery (n = 23). The primary outcome was best-corrected visual acuity (BCVA) at 12 months. The baseline BCVAs of the observation, anti-VEGF monotherapy, non-surgical gas tamponade, and subretinal surgery groups were 1.50 ± 0.70, 1.09 ± 0.70, 1.31 ± 0.83, and 1.62 ± 0.77 logarithm of minimal angle resolution (LogMAR), respectively. The mean BCVAs at 12 months were 1.39 ± 0.84, 0.90 ± 0.83, 1.35 ± 0.88, and 1.44 ± 0.91 LogMAR, respectively. After adjusting for age, baseline BCVA, SMH size, and the number of intravitreal anti-VEGF injections before SMH, the mean BCVA showed no significant difference among treatments at 12 months (P = 0.204). The anti-VEGF monotherapy group showed better mean BCVA significantly at 3 months (P < 0.001). Only baseline BCVA was associated with VA gain at 12 months (Odds ratio = 3.53, P < 0.001). This study demonstrated that there was no difference in 12 month visual outcomes among treatments and a better early visual outcome can be expected with anti-VEGF monotherapy.