bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer potential of turmeric (Curcuma longa) ethanol extract and prediction of its mechanism through the Akt1 pathway
Authors: Widyananda Muhammad Hermawan , Puspitarini Sapti , Rohim Abdul , Khairunnisa Fika Agalia , Jatmiko Yoga Dwi , Masruri Masruri , Widodo Nashi 
Published: September 2022

Background: Turmeric (Curcuma longa) has high potential as a traditional anticancer drug. This study aimed to analyze the anticancer activity of turmeric ethanol extract on T47D cells and examine the interaction of Akt1 protein with compounds contained in turmeric. Methods: The cytotoxicity assay was conducted using WST-1 reagents. Apoptosis assay used annexin V-PI, whereas cell cycle assay used PI, and then the results were analyzed using a flow cytometer. LC-HRMS analysis was conducted to identify the active compounds. Docking between Akt1 and ligands was performed using Autodock 4.2 software. Molecular dynamics simulations were conducted using YASARA with a time parameter of 20 ns, pH 7.4, and 37°C. Results: The extract had a strong toxicity on T47D cells (cytotoxicity IC50 value: 26.36 ± 1.55 µg/mL). The extract induced apoptosis of T47D cells at the IC50 dose (~30% cells) and induced the cell cycle arrest in G1 phase. Curcumin, 2-hydroxycinnamic acid and caryophyllene oxide had lower binding energy into Akt1 than AZD5363 used as a positive control. Curcumin, Ar-turmerone, and α-curcumene bind in the ATP binding pocket of Akt1, so the compounds have a high potential to be an ATP-competitive Akt1 inhibitors. The interaction of Akt1 with the compound contained in turmeric had an RMSD backbone value that was more stable than that of ATP and AZD5363. Root-mean-square fluctuation values indicated that amino acid residues that had an essential role in ligand binding sites were stable during simulation. Conclusions: The turmeric ethanol extract had a potential anti-cancer effect by inducing apoptosis and inhibiting cell cycle progression on T47D cells. The docking analysis showed that the active compounds of the extract, such as curcumin, Ar-turmerone, caryophyllene oxide, and α-curcumene, were able to bind into the ATP binding pocket of Akt1 that might inhibit the protein activity and induce cell cycle arrest.
Case Article—Blending Statistics, Optimization, and Simulation in a Multiphase Case
Authors: Gorman Michael Francis 
Published: September 2022

This case integrates three different methodologies over a four-part sequence on a problem that mirrors a real-world, published project. Students apply statistics, integer optimization, and simulation analysis toward solving the job assignment problem. The case features four parts: (1) operating cost and runtime estimation via regression, (2) mixed integer optimization analysis of a baseline and two scenarios, (3) simulation of the recommended solution under uncertainty, and (4) reoptimization under uncertainty. The case has been implemented over a one- to four-week period with upper level MBA or masters in analytics students. The case has received very positive feedback. History: This paper has been accepted for the INFORMS Transactions on Education Special Section on Cases Based on Real-World Projects from the INFORMS Journal on Applied Analytics. Supplemental Material: The supplemental material is available at https://doi.org/10.1287/ited.2022.0278ca . The Teaching Note and data files are available at https://www.informs.org/Publications/Subscribe/Access-Restricted-Materials .
A Real Utopia Under What Conditions? The Economic and Social Benefits of Workplace Democracy in Knowledge-Intensive Industries
Authors: Young-Hyman Trevor , Magne Nathalie , Kruse Douglas 
Published: September 2022

Given consistent evidence of its social benefits but questions about its market viability, this paper examines the conditions under which workplace democracy can be understood as a “real utopia”; a viable form of organization that is both economically productive and socially welfare enhancing. Conceptualizing democratic firms as organizations with formally distributed authority and collectivist norms, we argue that democratic firms will operate more productively in knowledge intensive industries, compared with conventional firms in the same industries, because they give authority to those with relevant knowledge and encourage intrafirm information sharing. Next, focusing on intrafirm wage inequality as a key social welfare outcome, we argue that knowledge-intensive sectors are also settings where the benefits of workplace democracy are likely to be greater. Knowledge intensive industries tend to generate greater intrafirm inequality through the adoption of market-based employment policies and reliance on unique expertise, yet the formal structure and collectivist norms of democratic firms are likely to limit these mechanisms of inequality, generating inequality reductions. We test these hypotheses with longitudinal linked employer-employee data from French cooperatives and conventional firms, including firms that shift organizational structures over time. We find robust support for our hypothesis about economic performance and moderate support for our hypothesis about social performance. Funding: This research has been generously supported by the Berg Center for Ethics, the Katz International Business Center, and the Bill Nobles Fellowship, as well as a public grant overseen by the French National Research Agency (ANR) as part of the “Investissements d’Avenir” program [Reference ANR-10-EQPX-17-Centre d’accès sécurisé aux données]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.1622 .
Ranges of pregnancy preferences and contraceptive use: Results from a population‐based survey in the southeast United States
Authors: Rocca Corinne H. , Smith Michael G. , Hale Nathan L. , Khoury Amal J. 
Published: September 2022

AbstractContextUnderstanding how pregnancy preferences shape contraceptive use is essential for guiding contraceptive interventions and policies that center individuals' preferences and desires. Lack of rigorous measurement of pregnancy preferences, particularly on the population level, has been a methodologic challenge.MethodsWe investigated associations between prospective pregnancy preferences, measured with a valid instrument, the Desire to Avoid Pregnancy (DAP) scale, and contraceptive use in a representative sample of 2601 pregnancy‐capable self‐identified women, aged 18–44 years, in Alabama and South Carolina (2017–2018). We used multivariable regression with weighting to investigate how probability of modern contraceptive use, and use of different contraceptive method types, changed with increasing preference to avoid pregnancy.ResultsDesire to Avoid Pregnancy scale scores (range:0–4, 4 = greater preference to avoid pregnancy, median = 2.29, IQR: 1.57–3.14; α:0.95) were strongly associated with contraceptive use among sexually active respondents (aPR = 1.15 [1.10, 1.20]; predicted 45% using contraception among DAP = 0, 62% among DAP = 2, 86% among DAP = 4). Method types used did not differ by DAP score. The most common reasons for nonuse were concern over side effects and not wanting to use a method (32% each) among respondents with mid‐range and high DAP scores. Among those with mid‐range DAP scores, 20% reported nonuse due to not minding if pregnancy were to occur (vs. 0% among those with high DAP scores).ConclusionsPregnancy preferences strongly influence likelihood of contraceptive use. Providion of appropriate contraceptive care to those not explicitly desiring pregnancy must differentiate between ranges of feelings about pregnancy, perceived drawbacks to contraceptive use, and legitimate psychological and interpersonal benefits of nonuse to promote autonomy in contraceptive decision‐making.
Provision of fertility services to women in same‐sex relationships at Catholic and non‐Catholic clinics in the United States
Authors: Stein Lara Elizabeth , Goldman Kara N. , Takimoto Sarah , Neshek Barbara , Guiahi Maryam 
Published: September 2022

AbstractIntroductionThis study addressed deficient information on the provision of infertility care in obstetrics and gynecology clinics. We additionally evaluated the availability of these services based on clinic affiliations or stated sexual orientation.MethodologyWe performed a national cross‐sectional “mystery caller” survey of 293 general obstetrics and gynecology clinics in 2017–2018. We matched clinics identified by web‐based search engine in a 1:1 ratio by Catholic hospital affiliation, after determining number of clinics based on state‐population densities. A standard call script included questions regarding provision of infertility services, ovulation induction methods, and information about the caller's sexual orientation. We performed descriptive frequencies and compared responses based on hospital affiliations.ResultsOf the 293 clinics included, 49% were affiliated with Catholic and 17% with academic hospitals. The majority offered infertility care (85%, 248/293), and of these 97% (240/248) offered ovulation induction. Only 3% (6/240) reported they would not provide to women in same‐sex relationships. Most clinics not offering infertility evaluations (43/45, 96%) cited it was outside of their scope of care and of these 33% (15/45) did not provide information for self‐referral. Clinics affiliated with academic (aOR 0.23) or Catholic (aOR 0.34) hospitals were less likely to provide evaluations. Those with academic affiliation were more likely to provide information for self‐referral (aOR 19.2).DiscussionMost general obstetrics and gynecology practices offered appointments for infertility evaluation and ovulation induction. Clinics rarely denied services to women reporting a same‐sex partnership, regardless of hospital affiliation. These findings provide reassurance to same‐sex couples seeking fertility care.
Transverse-pumping approach for a powerful single-mode Ti:sapphire laser for near infrared lidar applications
Authors: Vogelmann Hannes , Speidel Johannes , Perfahl Matthias , Trickl Thomas 
Published: September 2022

We present a design of a transversely pumped and powerful Ti:sapphire
laser, suitable for laser remote sensing in the near infrared (NIR)
spectrum. Examining multiple pump configurations revealed that
transversal pumping of Ti:sapphire crystals with a Nd:YAG laser
(532 nm) from one or two sides yields maximum output power. Together
with an optimized bow-tie resonator setup, we were able to extract up
to 3 W (30 mJ, 100 Hz) of narrowband NIR laser emission from a cuboid
50 mm long Ti:sapphire crystal. Beam quality and divergence were
determined as

M
x
2

=
1.1

,

M
y
2

=
1.7

,

φ
x

=
0.5

m
r
a
d

, and

φ
y

=
0.8

m
r
a
d

. The spectral purity (seeded,

P

s
e
e
d

≥
170

µ
W

) was better than 99.8%.
Additionally, we show a two-wavelength setup applicable to atmospheric
water vapor lidar. The principle performance of this theory of
operation suggests a good chance of scalability towards significantly
enhanced power of future Ti:sapphire lasers.
Tomographic imaging of carbon dioxide in the exhaust plume of large
commercial aero-engines
Authors: Upadhyay Abhishek , Lengden Michael , Enemali Godwin , Stewart George , Johnstone Walter , Wilson David , Humphries Gordon , Benoy Thomas , Black John , Chighine Andrea , Fisher Edward , Zhang Rui , Liu Chang , Polydorides Nick , Tsekenis Alex , Wright Paul , Kliment Joshua , Nilsson Johan , Feng Yutong , Archilla Victor , Rodríguez-Carmona Javier , Sánchez-Valdepeñas Jesús , Beltran Marta , Polo Valentin , Armstrong Ian , Mauchline Iain , Walsh Douglas , Johnson Mark , Bauldreay Joanna , McCann Hugh 
Published: September 2022

We report here the first implementation of chemically specific imaging in the exhaust plume of a gas turbine typical of those used for propulsion in commercial aircraft. The method used is chemical species tomography (CST) and the target species is

C
O

2

, absorbing in the near-infrared at 1999.4 nm. A total of 126 beams propagate transverse to the plume axis, along 7 m paths in a coplanar geometry, to probe a central region of diameter

≈
1.5

m

. The

C
O

2

absorption spectrum is measured using tunable diode laser spectroscopy with wavelength modulation, using the second harmonic to first harmonic (2f/1f) ratio method. The engine is operated over the full range of thrust, while data are recorded in a quasi-simultaneous mode at frame rates of 1.25 and 0.3125 Hz. Various data inversion methodologies are considered and presented for image reconstruction. At all thrust levels a persistent ring structure of high

C
O

2

concentration is observed in the central region of the measurement plane, with a raised region in the middle of the plume assumed to be due to the engine’s boat tail. With its potential to target various exhaust species, the CST method outlined here offers a new approach to turbine combustion research, turbine engine development, and aviation fuel research and development.
Obesity and functional bowel disorders in adolescents: a pilot study
Authors: Rychkova L. V. , Pogodina A. V. , Romanitsa A. I. , Savelkaeva M. V. 
Published: September 2022

Background: Studies of the relationship between obesity and functional bowel disorders, carried out in different age groups, provide conflicting results. It remains unclear what factors are responsible for the transition from a tendency to constipation in children to a tendency to diarrhea in adults with obesity.Aim: To establish factors related to stool consistency as a surrogate marker of colon transit in adolescents with obesity.Materials and methods: A single-center observational cross-sectional study was carried out. We consecutively recruited adolescents, aged 11–17 years with obesity. Socio-demographic characteristics, lifestyle and nutritional characteristics were assessed using questionnaires. Bowel symptoms were assessed using questionnaires and interviews. Stool consistency was assessed using the Bristol Stool Form Scale. Serum concentrations of ALT, AST, bilirubin, cholesterol, glucose, HbA1c, leptin, and insulin were determined. The HOMA-IR index was used to determine insulin resistance.Results: One hundred and ten adolescents with obesity were enrolled in the study. Of these, 69.1% had a pathological consistency of feces, with the prevalence of forms characterizing delayed gut transit (49.1%). The predominance of loose stools was reported by 5.5% of patients. The combination of different forms of stool (unstable stool) was described by 14.5% of adolescents. Hard stools were common among adolescents from single-parent families and adolescents who rarely consume dairy products. The presence of loose stools has been associated with insulin resistance.Conclusion: Most obese adolescents who do not have abdominal complaints have colon transit disorders. Medical professionals should actively ask these patients about stool frequency and properties. With constipation, dietary correction is justified. Research is needed to investigate in-depth gut microbiota as a possible link between obesity and diarrhea.
Comparison of the accuracy of resting energy expenditure assessment using bioimpedance analysis and indirect respiratory calorimetry in children with simple obesity
Authors: Okorokov P. L. , Vasyukova O. V. , Bezlepkina O. B. 
Published: September 2022

Background: Assessment of resting energy expenditure (REE) is necessary for the formation of a diet for obesity patients. The «gold standard» for assessment of resting energy expenditure (REE) is indirect respiratory calorimetry. Currently, bioimpedance analyzers are increasingly being used in clinical practice to assess energy consumption at rest, including in obese children. However, the accuracy of such an assessment remains unclear.Aims: To determine the accuracy of the assessment of resting energy expenditure using bioimpedance analysis in children with simple obesity compared with indirect respiratory calorimetry.Materials and methods: Resting energy expenditure was assessed by bioimpedance analysis, Harris-Benedict formula and indirect respiratory calorimetry in all obese children. Comparability of methods was assessed using the Bland-Altman analysis.Results: The study included 320 children aged 7 to 17 years with simple obesity.Resting energy expenditure assessed by bioimpedance analysis was on average 232 kcal lower than the actual. A significant CI (-448 to 912 kcal) was revealed, as well as a large LOA from -514 to 979 kcal. REE calculated by the Harris-Benedict formula on average corresponded to the actual one, and CI varied from -38 to 27 kcal. However, large LOA from -514 to 979 kcal, indicating a high individual variability of resting energy consumption.Conclusions: Bioimpedance analyzers underestimate REE in obese children compared to indirect respiratory calorimetry and the Harris-Benedict formula. Given the significant discrepancies in the accuracy of REE assessment, bioimpedance analysis cannot be considered as an alternative to indirect respiratory calorimetry to assess resting energy in children with simple obesity.
Dihydrotachysterol: a bad choice in the treatment of chronic hypoparathyroidism
Authors: Avsievich E. S. , Kovaleva E. V. , Gorbacheva A. M. , Eremkina A. K. , Mokrysheva N. G. 
Published: September 2022

Hypoparathyroidism is an endocrine disease caused by damage of the parathyroid glands and characterized by underproduction of parathyroid hormone. This can lead to severe hypocalcemia and its associated complications. The chronic hypoparathyroidism requires lifelong therapy including calcium and vitamin D analogues. The goal of treatment is to maintain the target parameters of phosphorus-calcium metabolism. At the same time, there is a risk of iatrogenic hypercalcemia on the standard therapy, up to the hypercalcemic crisis, often complicated by the acute renal failure. Moreover, chronic hypercalcemia acts as a predisposing factor for nephrolithiasis, nephrocalcinosis, chronic renal failure including pre- and dialysis stages.Dihydrotachysterol is a synthetic analogue of vitamin D, which was previously widely prescribed for hypocalcaemic hypoparathyroidism. In accordance with modern Russian and international guidelines, this drug should not be used in the treatment of chronic hypoparathyroidism. The main features in the metabolism of dihydrotachysterol (long elimination period, lack of feedback regulation of the active metabolites, high biological activity) and a narrow therapeutic window cause the frequent development of hypercalcemia and associated disorders.We present several clinical cases of patients with hypoparathyroidism treated with dihydrotachysterol, which was complicated by severe hypercalcemia and acute renal failure.
STATE-OF-ART KONSERVASI BANGUNAN DAN CAGAR BUDAYA MELALUI PEMBENTUKAN MODEL 3 DIMENSI BERBASIS TEKNIK FOTOGRAMMETRI RENTANG DEKAT
Authors: Prasetyo Yudo 
Published: September 2022

Pada umumnya bangunan bersejarah dan cagar budaya yang berada di permukaan bumi sebagian besar merupakan objek tiga dimensi yang belum terdokumentasi dengan baik. Oleh karena itu pembentukan data dasar 3D yang digunakan untuk melakukan pemodelan objek tiga dimensi harus memiliki tingkat ketelitian yang baik dan geometri yang baik juga. Pada penelitian ini, dipaparkan pendekatan state-of-art dari metode-metode yang digunakan didalam pembentukan dokumentasi 3D untuk konservasi dan dokumentasi bangunan yaitu melalui penerapan metode fotogrammetri jarak dekat yang menggunakan kamera digital non metrik, Terrestrial Laser Scanner (TLS) dan Unmanned Aerial Vehicle (UAV). Untuk tahapan pelaksanaan penelitian terbagi atas tahapan kalibrasi kamera, pemotretan objek dan pengolahan model 3 dimensi. Untuk konsep akuisi data dibutuhkan proses kalibrasi yang direkomendasikan memenuhi angka 80% sebagai syarat kalibrasi peralatan survey. Untuk pengambilan data foto dilapangan dilakukan sebanyak mungkin akuisisi dengan pertampalan antar obyek berkisar minimal 60%-80% dan pengolahan data pada penelitian ini menggunakan perangkat lunak 3D seperti PhotoModeler Scanner dan Summit Evolution. Untuk validasi hasil pembentukan model 3D dapat menggunkan nilai perbandingan uji statistik titik geometrik dengan peralatan survey Electronic Total Station (ETS). Tahap pemodelan bangunan terdiri dari Automated Project, proses hitungan dan pembuatan model 3D, transformasi koordinat 3D, visualisasi model 3D dan analisis statistik sebaran titik-titik geometrik. Hasil akhir dalam penelitian ini adalah model tiga dimensi bangunan yang telah melalui proses pengujian perbandingan jarak yang diikatkan dari pengukuran ETS dan dianalisis lebih lanjut untuk nilai standar deviasi dari perbandingan jaraknya.
ANALISIS KUALITAS AIR DI DANAU BATUR MENGGUNAKAN CITRA LANDSAT-8 OLI/TIRS MULTITEMPORAL
Authors: Laili Silmina 
Published: September 2022

Danau Batur terletak di Kabupaten Bangli Provinsi Bali. Keberadaan Danau Batur dengan area yang begitu luas menjadikannya memiliki peranan yang sangat penting bagi masyarakat sekitar yaitu sebagai penyedia sumber air utama. Danau Batur juga memiliki peranan penting dalam sektor perikanan, pertanian, pariwisata dan kegiatan keagamaan. Berdasarkan pada fungsi dan peran utama dari Danau Batur, maka dirasa perlu adanya suatu pengamatan terhadap kualitas air yakni meliputi nilai Total Suspended Solid, tingkat kecerahan dan klorofil-a di Danau Batur. Tingginya nilai TSS akan mempengaruhi tingkat kecerahan air danau tersebut. Selain itu juga berpotensi menurunkan penetrasi cahaya yang masuk ke perairan dan berpengaruh pada kesuburan perairan. Dimana kondisi ini sering diindikasikan dengan keberadaan klorofil-a sebagai indikator biomassa fitoplankton. Dalam penelitian ini digunakan citra satelit Landsat-8 untuk pengamatan kualitas air di Danau Batur tahun 2014-2018. Pengolahan nilai TSS citra memanfaatkan algoritma Trisakti. Sedangkan pengolahan nilai klorofil-a citra memanfaatkan algoritma Wibowo. Hasil penelitian menunjukkan bahwa persentase terbesar nilai TSS di danau Batur pada rentang <25 mg/L tahun 2014, 2015, 2016, 2017 dan 2018 berturut-turut adalah 97,86%, 98,19%, 98,62%, 98,15% dan 98,66%. Persentase kecerahan pada kondisi hiperutrofik dengan transparasi 0-70 cm pada tahun 2014, 2015, 2016, 2017 dan 2018 berturut-turut adalah 2,53%, 2,74%, 1,66%, 2,52% dan 2,25%. Sedangkan persentase terbesar nilai klorofil-a pada rentang <2 mg/m3 tahun 2014, 2015, 2016, 2017 dan 2018 berturut-turut adalah 91,41%, 93,3%, 92,71%, 92,64% dan 92,16%. Berdasarkan hasil pengamatan, nilai TSS di Danau Batur pada tahun 2014-2018 tergolong tidak berpengaruh terhadap kepentingan perikanan dan nilai klorofil-a tergolong pada kondisi oligotrof.
The Stability of Knowledge
Authors: Bjelde Joseph 
Published: September 2022

Abstract
Socrates’ official answer to Meno’s question about the value of knowledge, near the end of Plato’s Meno, is that knowledge is stable. I argue that both the answer and the question have been widely misunderstood. The question has been taken to be why knowing at a time is better than true belief at that time, and Socrates’ answer has been taken to point to the greater persistence of knowledge over time. I argue instead that, given the broader context of the question and answer in the Meno, together with what Plato has to say about stability elsewhere, Meno’s question is better understood as a more difficult question – and Socrates’ answer as a good solution to it. This also involves arguing that Socrates’ analogy to the statues of Daedalus is not intended as the simple illustration of Socrates’ official answer for which commentators have taken it.