bluuebunny/crossref_metadata_2025_split huggingface dataset:
Switching to daratumumab SC from IV is safe and preferred by patients with multiple myeloma
Authors: Mateos Maria-Victoria , Rigaudeau Sophie , Basu Supratik , Spicka Ivan , Schots Rik , Wrobel Tomasz , Cook Gordon , Beksac Meral , Gries Katharine S , Kudva Anupa , Tromp Brenda , Van Rampelbergh Rian , Pei Huiling , Wroblewski Susan , Carson Robin , Delioukina Maria , White Darrell 
Published: September 2022

Introduction Two phase 3 studies demonstrated superior efficacy of intravenous daratumumab (DARA IV) plus bortezomib/melphalan/prednisone (ALCYONE) or lenalidomide/dexamethasone (Rd; MAIA) versus standard-of-care regimens for transplant-ineligible newly diagnosed multiple myeloma. In these studies, patients could switch from DARA IV to subcutaneous daratumumab (DARA SC) while receiving daratumumab monotherapy in ALCYONE (as of Cycle 11) or daratumumab plus Rd in MAIA. The phase 3 COLUMBA study demonstrated noninferiority of DARA SC to DARA IV. DARA SC reduced administration time, allowing patients to spend less time in healthcare settings, a relevant practical consideration for patient care in the COVID-19 pandemic/settings of limited healthcare resources. Methods DARA SC 1800 mg was administered every 4 weeks, per approved dosing schedules. We evaluated safety and patient-reported experience (ALCYONE only) among patients who switched from DARA IV to DARA SC. Results Fifty-seven patients in ALCYONE and 135 in MAIA switched to DARA SC. Three (2.2%; MAIA) patients reported injection-site reactions, all of which were mild. No infusion-related reactions occurred with DARA SC. In ALCYONE, >80% of patients preferred DARA SC over DARA IV. Grade 3/4 treatment-emergent adverse events (TEAEs) occurred in 5.3% of patients in ALCYONE and 25.9% in MAIA; one (0.7%; MAIA) patient experienced a TEAE with an outcome of death. Conclusion For transplant-ineligible newly diagnosed multiple myeloma, DARA SC (monotherapy/with Rd) was safe and preferred over DARA IV. ClinicalTrials.gov, NCT02195479/NCT02252172.
Leptomeningeal Metastasis Mimicking a Subacute Epidural Hematoma: Case Report
Authors: Amal Lahfidi , Wend-Yam Mohamed Traore , Kaoutar Imrani , Hounayda Jerguigue , Rachida Latib , Youssef Omor 
Published: September 2022

Leptomeningeal carcinomatosis is extremely rare in colorectal adenocarcinoma, its incidence is far less than 1%. The neurological symptoms are pleomorphic. The most common symptoms included Headache, ataxia, cranial nerve palsies, meningismus, focal weakness or numbness. MRI is the most sensitive and specific imaging method for screening, positive diagnosis and pre-treatment of leptomeningeal carcinomatosis. The presence of appropriate neuroimaging abnormalities in a patient with typical clinical features and history of colorectal adenocarcinoma enables to make the diagnosis of leptomeningeal metastases. As well as a biological confirmation is necessary. Treatment usually comprises site-specific radiation therapy in addition to intrathecal and systemic chemotherapy. The case aims to describe the MRI characteristics of leptomeningeal metastases so as to formulate the diagnosis and the subsequent treatment.
Parents’ perceptions of the impact of COVID-19 and school transition on autistic children’s friendships
Authors: Fox Laura , Asbury Kathryn , Code Aimee , Toseeb Umar 
Published: September 2022

Friendships play a key role in supporting a successful transition to a new school for autistic children and young people. However, little is known about how these relationships have been impacted by restrictions put in place during the COVID-19 pandemic. This study aimed to explore how parents perceived the impact of COVID-19 on their autistic child’s friendships during transition to a new school. Semi-structured interviews were carried out with 14 parents of autistic children in the United Kingdom. Data were analysed using reflexive thematic analysis. Parents discussed a variety of experiences, which differed between and within school types and age groups. Several factors influenced children’s friendships during transition including support from their new school and others’ understanding of their needs. Parents described the differing expectations of what friendship was and how that affected their children’s existing and new relationships. For some, COVID-19 negatively impacted on friendships by reducing contact with existing and new friends. Others experienced positive or neutral experiences due to lockdown restrictions. This study highlights the diversity of needs among autistic children and calls for a personalised approach to transition support beyond the pandemic as one way of supporting autistic children to develop positive peer relationships. Lay abstract Research shows that moving schools can be a challenging time for autistic children and young people. One factor that has been found to support successful transition is friendships. However, there is little research exploring how transition between schools affects autistic children’s friendships, and even less on how children’s relationships during transition have been impacted by COVID-19. Fourteen parents of autistic children and young people were interviewed about their child’s move to a new school and the impact they felt this had on their friendships. Parents described how moving with existing friends helped some children to find the transition less challenging. Others had differing experiences, with their children’s friendships playing a much smaller role in the move. Differences were also seen with regard to the impact of COVID-19, with some parents speaking of how hard being away from friends was for their child, while others found the social restrictions a welcome break from interacting with peers. The study highlights how different the experiences of autistic individuals, and their parents, can be and the importance of a child-centred approach to transition support.
Scoping review of research practices in the investigation of bilingual effects on inhibition and attention in young people
Authors: Privitera Adam John , Weekes Brendan 
Published: September 2022

Aims and objectives: The aim of this scoping review is to curate and summarize research methodologies used to assess the effects of bilingualism on inhibition and attention in young people. Methodology: The methodology of a scoping review was followed. Searches of the literature using inclusive search strings were conducted using PubMed, Scopus, Proquest, and PsyArXiv. Study selection followed the guidance of the PRISMA-ScR checklist with published and unpublished studies included. Data and analysis: Extracted data included study authors, year of publication, source format (e.g., journal article, thesis), country in which the study was conducted, sample size, average age of participants in the sample, language combination used by participants in the bilingual sample, task(s) used to assess inhibition, task(s) used to assess attention, and method used for data analysis. Findings and conclusions: Studies identified were disproportionately conducted in English-speaking (Western) language environments, based on bilingual samples who were proficient in English and a second language that was typically a related Indo-European language (e.g., English-Spanish). Tasks employed were most often aimed at measuring differences in inhibition compared with attention. Finally, almost all studies were limited to between group designs and fixed-effects analysis methods. Future research can be improved through inclusion of samples from a wider range of language backgrounds that is representative of more diverse language combinations, and underrepresented age groups. Furthermore, within participant mixed-effects analysis methods that account for the diversity of bilingual experience would strengthen the methodological rigor of future studies. Originality: This is the first scoping review focused on methods used to investigate bilingual effects in young people. Significance: We provide strong evidence that standard methods ignore nontrivial differences in bilingual experience. In addition, Westocentric sampling trends provide an incomplete and biased understanding of the true effects of bilingualism.
Dimethyl fumarate attenuates pain behaviors in osteoarthritis rats via induction of Nrf2-mediated mitochondrial biogenesis
Authors: Gao Shao-Jie , Li Dan-Yang , Liu Dai-Qiang , Sun Jia , Zhang Long-Qing , Wu Jia-Yi , Song Fan-He , Zhou Ya-Qun , Mei Wei 
Published: September 2022

Osteoarthritis (OA), a chronic degenerative disease, leads to pain and loss of function. Existing treatments for OA pain have limited efficacy and show significant side effects. Dimethyl fumarate, a robust nuclear factor erythroid 2-related factor 2 (Nrf2) activator, could alleviate pain behaviors in chronic pain. This study aims to investigate the role of dimethyl fumarate in a rat model of OA induced by monosodium iodoacetate (MIA) and its underlying mechanisms. We used von Frey filaments to assess the mechanical allodynia. Weight-bearing apparatus was employed to assess the hindlimb weight distribution. Western blot was employed to investigate the protein expressions of mitochondrial biogenesis markers. RT-qPCR was employed to examine the copy number of mitochondrial DNA (mtDNA). In our study, dimethyl fumarate upregulated mechanical paw withdrawal threshold (MPWT) (MIA + Vehicle, 1.6 ± 0.13 g [mean ± SEM]; MIA + Dimethyl fumarate (DMF) 300 mg/kg, 10.5 ± 0.96 g; p < 0.0001). Hindlimb weight distribution was also upregulated by dimethyl fumarate (MIA + Vehicle, 38.17 ± 0.72 g; MIA + DMF 300 mg/kg, 43.59 ± 1.01 g; p < 0.01). Besides, activation of Nrf2 remarkably upregulated the protein levels of PGC-1α (MIA + Vehicle, 0.69 ± 0.07; MIA + DMF 300 mg/kg, 1.08 ± 0.09; p = 0.0037), NRF1 (MIA + Vehicle, 0.69 ± 0.04; MIA + DMF 300 mg/kg, 1.00 ± 0.11; p = 0.0114), TFAM (MIA + Vehicle, 0.62 ± 0.11; MIA + DMF 300 mg/kg, 1.02 ± 0.12; p = 0.0147), and the copy number of mtDNA (MIA + Vehicle, 0.52 ± 0.05; MIA + DMF 300 mg/kg, 3.81 ± 0.21; p < 0.0001). Taken together, these results show that dimethyl fumarate alleviated pain-related behaviors in a rat model of OA through activation of Nrf2-induced mitochondrial biogenesis.
Distinguish bipolar and major depressive disorder in adolescents based on multimodal neuroimaging: Results from the Adolescent Brain Cognitive Development study®
Authors: Liu Yujun , Chen Kai , Luo Yangyang , Wu Jiqiu , Xiang Qu , Peng Li , Zhang Jian , Zhao Weiling , Li Mingliang , Zhou Xiaobo 
Published: September 2022

Background Major depressive disorder and bipolar disorder in adolescents are prevalent and are associated with cognitive impairment, executive dysfunction, and increased mortality. Early intervention in the initial stages of major depressive disorder and bipolar disorder can significantly improve personal health. Methods We collected 309 samples from the Adolescent Brain Cognitive Development study, including 116 adolescents with bipolar disorder, 64 adolescents with major depressive disorder, and 129 healthy adolescents, and employed a support vector machine to develop classification models for identification. We developed a multimodal model, which combined functional connectivity of resting-state functional magnetic resonance imaging and four anatomical measures of structural magnetic resonance imaging (cortical thickness, area, volume, and sulcal depth). We measured the performances of both multimodal and single modality classifiers. Results The multimodal classifiers showed outstanding performance compared with all five single modalities, and they are 100% for major depressive disorder versus healthy controls, 100% for bipolar disorder versus healthy control, 98.5% (95% CI: 95.4–100%) for major depressive disorder versus bipolar disorder, 100% for major depressive disorder versus depressed bipolar disorder and the leave-one-site-out analysis results are 77.4%, 63.3%, 79.4%, and 81.7%, separately. Conclusions The study shows that multimodal classifiers show high classification performances. Moreover, cuneus may be a potential biomarker to differentiate major depressive disorder, bipolar disorder, and healthy adolescents. Overall, this study can form multimodal diagnostic prediction workflows for clinically feasible to make more precise diagnose at the early stage and potentially reduce loss of personal pain and public society.
Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis
Authors: Xiao Juan , Zeng Wenying , Zhang Pengcheng , Zhou Yuan , Fang Qiangqiang 
Published: September 2022

Abstract
Background
Acute pancreatitis is the sudden inflammation of the pancreas. Severe cases of acute pancreatitis are potentially fatal and have no specific treatment available. Premature trypsinogen activation could initiate acute pancreatitis. However, the mechanism underlying premature trypsinogen activation is not fully understood.

Methods
In this research, a primary pancreatic acinar cell or mouse acute pancreatitis model was constructed. The effect of acid ceramidase (ASAH1), which is responsible for sphingosine production, was investigated in trypsinogen activation in vitro and in vivo. Meanwhile, the proteins regulating ASAH1 or binding to sphingosine were also detected by co-immunoprecipitation followed by mass spectrometry.

Results
The results showed that ASAH1 increased in acute pancreatitis. Increased ASAH1 promoted the activation of trypsinogen and cathepsin B. On the contrary, ASAH1 downregulation inhibited trypsinogen and cathepsin B. Meanwhile, ASAH1 regulated the activity of trypsin and cathepsin B through sphingosine. Additionally, E3 ligase Mind bomb homolog 1 (MIB1) decreased in acute pancreatitis resulting in the decreased binding between MIB1 and ASAH1. Exogenous MIB1 diminished the elevation in trypsin activity induced by acute pancreatitis inducer. ASAH1 increased owing to the inhibition of the proteasome degradation by MIB1. In acute pancreatitis, sphingosine was found to bind to pyruvate kinase. Pyruvate kinase activation could reduce trypsinogen activation and mitochondrial reactive oxygen species (ROS) production induced by sphingosine.

Conclusions
In conclusion, during the process of acute pancreatitis, MIB1 downregulation led to ASAH1 upregulation, resulting in pyruvate kinase inhibition, followed by trypsinogen activation.
Flexible Scanning Method by Integrating Laser Line Sensors with Articulated Arm Coordinate Measuring Machines
Authors: Xie Zexiao , Yu Ping , Gong Hanlei , Chi Shukai , Gao Xiang 
Published: September 2022

AbstractMeasuring and reconstructing the shape of workpieces have been considered as a fundamental step in both reverse engineering and product quality control. Owing to increasing structural complexity of recent products, measurements from multiple directions are typically required in current scanning techniques. Specifically, the plane structured light can be applied to measure one area of a part at a time, with an additional algorithm required to merge the collected data of each area. Alternatively, the line structured light sensor integrated on CNC machines or CMMs could also realize multi-view measurement. However, the system needs to be repeatedly calibrated at each new direction. This paper presents a flexible scanning method by integrating laser line sensors with articulated arm coordinate measuring machines (AACMM). Since the output of the laser line sensor is 2D raw data in the laser plane, our system model introduces an explicit transformation from the 2D sensor coordinate frame to the 3D base coordinate frame of the AACMM (i.e., the translation and rotation the of the 2D sensor coordinate in the sixth coordinate system of AACMM). To solve the model, the “conjugate pairs” are proposed and identified by measuring a fixed point (e.g., a sphere center). Moreover, a search algorithm is adopted to find the optimal solution, which noticeably boosts the model accuracy. The experimental results show that the error of the system is about 0.2 mm, which is caused by the error of the AACMM, the sensor error and the calibration error. By measuring a complicated part, the proposed system is proved to be flexible and facilitate, with the ability to measure a part expediently from any necessary direction. Furthermore, the proposed calibration method can also be used for robot hand-eye relationship calibration.
Quantity changes in acute headache medication use among patients with chronic migraine treated with eptinezumab: subanalysis of the PROMISE-2 study
Authors: Cowan Robert P. , Marmura Michael J. , Diener Hans-Christoph , Starling Amaal J. , Schim Jack , Hirman Joe , Brevig Thomas , Cady Roger 
Published: September 2022

Abstract
Background
Patients with chronic migraine (CM) treated with eptinezumab in the PROMISE-2 trial achieved greater reductions in migraine and headache frequency, impact, and acute headache medication (AHM) use than did patients who received placebo. This post hoc analysis examines relationships between headache frequency reductions and changes in AHM use in patients in PROMISE-2.

Methods
PROMISE-2 was a double-blind, placebo-controlled trial conducted in adults with CM. Patients were randomized to eptinezumab 100 mg, 300 mg, or placebo, administered intravenously once every 12 weeks for up to two doses. Patients recorded headache/AHM information daily and for each event in an electronic diary; data from all days with daily reports were included. Shifts in headache frequency and AHM use were assessed in the three populations: total CM population, patients with CM and medication-overuse headache (MOH), and patients with CM and MOH who were ≥ 50% responders during treatment (response over weeks 1–24).

Results
A total of 1072 adults with CM received treatment (eptinezumab, n = 706; placebo, n = 366). Mean baseline headache frequency was 20.5 days; mean baseline AHM days was 13.4; 431 patients had MOH, of which 225 (52.2%) experienced ≥50% response over weeks 1–24. Relative to baseline, the proportion of days with both headache and AHM use decreased 25.1% (eptinezumab) versus 17.0% (placebo) in the total population (N = 1072), 29.2% versus 18.4% in the MOH subpopulation (n = 431), and 38.3% versus 31.5% in the CM with MOH population with ≥50% response subgroup (n = 225) during weeks 1–24. The proportion of days with headache and triptan use decreased 9.1% (eptinezumab) versus 5.8% (placebo), 11.8% versus 7.2%, and 14.5% versus 12.6%, respectively. Reductions in other AHM types were smaller.

Conclusions
In this post hoc analysis, eptinezumab use in patients with CM was associated with greater decreases in days with headache with AHM overall and with triptans in particular. The magnitude of effect was greater in the subgroup of CM patients with MOH and ≥ 50% response.

Trial registration
ClinicalTrials.gov Identifier: NCT02974153.

Graphical abstract
Eptinezumab reduces headache frequency and acute medication use in patients with chronic migraine.
Facile Preparation of Four-Layer MoS2 Nanosheets and Their Application to Organic Light-Emitting Diode
Authors: Jiang Xingwang , Cheng Jie , Liu Ping , Gao Qingguo , Liu Liming 
Published: September 2022

AbstractHigh-quality four-layer molybdenum disulfide (MoS2) nanosheets with lateral dimension of about 11 µm were prepared by ultrasonic treatment of MoS2 powder with assistance of 1-methyl-2-pyrrolidone (NMP) solvent. The optimal preparation conditions for the preparation of MoS2 nanosheets were investigated from the aspects of ultrasonic processing time, ultrasonic power and amount ratio of MoS2 powder and NMP solvent. At the same time, the MoS2 nanosheets were employed as anode buffer layer in organic light-emitting diode (OLED) with copper nanowire (CuNW) film being anode. MoS2 nanosheets can reduce roughness of CuNW film, protect CuNW film from oxidation and improve work function of CuNW film. Experiments show that MoS2 nanosheets can significantly improve the current density and brightness of the OLED with CuNW film being anode. The maximum brightness of the OLED with MoS2 anode buffer layer is 2.15 times that of the OLED without MoS2 anode buffer layer. The current density of the OLED with MoS2 anode buffer layer is also obviously increased compared with the OLED without MoS2 anode buffer layer.
Hormone biosynthesis and metabolism members of 2OGD superfamily are involved in berry development and respond to MeJA and ABA treatment of Vitis vinifera L
Authors: Gao Yingying , Wang Xiaochen , Liu Xianju , Liang Zhenchang 
Published: September 2022

AbstractBackgroundHormones play an indispensable role during fruit ripening, nine clades in 2-oxoglutarate-dependent dioxygenase (2OGD) superfamily are responsible for the hormone biosynthesis and metabolism, but less information is known about them.ResultsA total of 163Vv2OGDsuperfamily members were identified from grape genome, which were mainly expanded by local (tandem and proximal) duplication. Phylogenetic analysis of 2OGD members in grape andArabidopsisindicates 37 members in Vv2OGD superfamily are related to hormone biosynthesis and metabolism process (Vv2OGD-H), which could be divided into 9 clades, gibberellin (GA) 3-oxidase (GA3ox), GA 20-oxidase (GA20ox), carbon-19 GA 2-oxidase (C19-GA2ox), carbon-20 GA 2-oxidase (C20-GA2ox), 1-aminocyclopropane-1-carboxylic acid oxidase (ACO), dioxygenase for auxin oxidation (DAO), lateral branching oxidoreductas (LBO), downy mildew resistant 6 and DMR6-like oxygenase (DMR6/DLO) and jasmonate-induced oxygenase (JOX). Sixteen of these 37Vv2OGD-Hsare expressed in grape berry, in which the expression patterns ofVvGA2oxs,VvDAOsandVvJOXsshows a correlation with the change patterns of GAs, indole-3-acetic acid (IAA) and jasmonates (JAs), indicating the involvement of these genes in grape berry development by regulating corresponding hormones. TwelveVv2OGD-Hsrespond to methyl JA (MeJA) treatment, of which eight may lead to the inhibition of the ripening process by the crosstalk of JAs-salicylic acids (SAs), JAs-GAs and JAs-JAs, while sevenVv2OGD-Hsrespond to ABA treatment may be responsible for the promotion of ripening process by the interplay of abscisic acid (ABA)-strigolactones (SLs), ABA-SAs, ABA-GAs, ABA-JAs. Especially,VvLBO1reach an expression peak near véraison and up-regulate about four times after ABA treatment, which implies SLs and ABA-SLs crosstalk may be related to the onset of berry ripening in grape.ConclusionsThis study provides valuable clues and new insights for the mechanism research ofVv2OGD-Hsin hormones regulation during the grape berry development.