bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of subjective cognitive complaints for detecting mild cognitive impairment in older adults across cultural and linguistic groups: A comparison of the Cognitive Function Instrument to the Montreal Cognitive Assessment
Authors: Li Clara , Hong Yue , Yang Xiao , Zeng Xiaoyi , Ocepek‐Welikson Katja , Eimicke Joseph P. , Kong Jian , Sano Mary , Zhu Carolyn , Neugroschl Judith , Aloysi Amy , Cai Dongming , Martin Jane , Loizos Maria , Sewell Margaret , Akrivos Jimmy , Evans Kirsten , Sheppard Faye , Greenberg Jonathan , Ardolino Allison , Teresi Jeanne A. 
Published: October 2022

AbstractIntroductionThis pilot study aims to explore the psychometric properties of the Cognitive Function Instrument (CFI) as a measure of subjective cognitive complaints (SCC) and its performance in distinguishing mild cognitive impairment (MCI) from normal control (NC) compared to an objective cognitive screen (Montreal Cognitive Assessment [MoCA]).MethodsOne hundred ninety‐four community‐dwelling non‐demented older adults with racial/ethnic diversity were included. Unidimensionality and internal consistency of the CFI were examined using factor analysis, Cronbach's alpha, and McDonald's omega. Logistic regression models and receiver operating characteristic (ROC) analysis were used to examine the performance of CFI.ResultsThe CFI demonstrated adequate internal consistency; however, the fit for a unidimensional model was suboptimal. The CFI distinguished MCI from NC alone or in combination with MoCA. ROC analysis showed comparable performance of the CFI and the MoCA.DiscussionOur findings support the use of CFI as a brief and easy‐to‐use screen to detect MCI in culturally/linguistically diverse older adults.HighlightWhat is the key scientific question or problem of central interest of the paper?Subjective cognitive complaints (SCCs) are considered the earliest sign of dementia in older adults. However, it is unclear if SCC are equivalent in different cultures. The Cognitive Function Instrument (CFI) is a 14‐item measure of SCC. This study provides pilot data suggesting that CFI is sensitive for detecting mild cognitive impairment in a cohort of older adults with racial/ethnic diversity. Comparing performance, CFI demonstrates comparable sensitivity to the Montreal Cognitive Assessment, an objective cognitive screening test. Overall, SCC may provide a non‐invasive, easy‐to‐use method to flag possible cognitive impairment in both research and clinical settings.
Redesign of Rifamycin Antibiotics to Overcome ADP‐Ribosylation‐Mediated Resistance
Authors: Lan Tian , Ganapathy Uday S. , Sharma Sachin , Ahn Yong‐Mo , Zimmerman Matthew , Molodtsov Vadim , Hegde Pooja , Gengenbacher Martin , Ebright Richard H. , Dartois Véronique , Freundlich Joel S. , Dick Thomas , Aldrich Courtney C. 
Published: October 2022

AbstractRifamycin antibiotics are a valuable class of antimicrobials for treating infections by mycobacteria and other persistent bacteria owing to their potent bactericidal activity against replicating and non‐replicating pathogens. However, the clinical utility of rifamycins against Mycobacterium abscessus is seriously compromised by a novel resistance mechanism, namely, rifamycin inactivation by ADP‐ribosylation. Using a structure‐based approach, we rationally redesign rifamycins through strategic modification of the ansa‐chain to block ADP‐ribosylation while preserving on‐target activity. Validated by a combination of biochemical, structural, and microbiological studies, the most potent analogs overcome ADP‐ribosylation, restored their intrinsic low nanomolar activity and demonstrated significant in vivo antibacterial efficacy. Further optimization by tuning drug disposition properties afforded a preclinical candidate with remarkable potency and an outstanding pharmacokinetic profile.
Modular and Fast Synthesis of Versatile Secondary α,α‐Dialkyl Boronates via Deoxygenative Alkylboration of Aldehydes
Authors: Xu Wenhao , Zheng Purui , Zhou Jun , Hu Zihao , XU Tao 
Published: October 2022

AbstractSecondary α,α‐dialkyl boronates are widely used due to their great versatility. Herein we report an unprecedented deoxygenative alkylboration of aldehydes, a facile method to access this type of products. A sequence of difunctionalization can be obtained smoothly from the readily available aldehydes in only two steps. This difunctionalization of aldehydes rather than conventional alkenes also opens new possibilities within the field.
Botanical Description, Traditional Uses, Phytochemistry, and Pharmacology of the Genus Artabotrys: A Review
Authors: Quang Hop Nguyen , The Son Ninh 
Published: October 2022

AbstractArtabotrys is a genus of small trees in the family Annonaceae. This genus contained over 100 perennial medicinal plants available in the old world tropics. Artabotrys plants have a lengthy history of use in medicine for malaria, diarrhea, backache, and scrofula treatments, as well as some of which were used as tea‐like beverages. About 90 reports were reviewed from inception to now, in which the decoctions of about 9 species were used in traditional folk medicines. With 234 isolated compounds, Artabotrys metabolites can be classified as alkaloids, terpenoids, sterols, flavonoids, polyoxygenated cyclohexenes, fatty acids, acetogenins, etc. Significantly, alkaloidal aporphines were separated and identified as the main isolates. Artabotrys plants are also rich in the essential oils. Especially, A. hexapetalus exerted a great role in perfumery industry. Artabotrys constituents possessed various pharmacological values, such as antioxidative, antidiabetic, hepatoprotective, and mosquito repellency, but cytotoxic and antimicrobial activities are the most striking features. In conclusion, Artabotrys plant extracts and their metabolites are of great socio‐economic importance, thereby more and more phytochemical and pharmacological investigations are expected.
Recent Advances in Rare‐Earth Metal‐Catalyzed C−H Functionalization Reactions
Authors: Sun Qianlin , Xu Xian , Xu Xin 
Published: October 2022

AbstractThere has been a persistent impetus for the development of versatile C−H functionalization reactions, which represents a powerful approach to a wide variety of valuable chemical compounds. Transition metal catalyzed C−H functionalization has attracted intense interest and witnessed considerable advances in this field owing to its outstanding regioselectivity and atom‐economy. In recent years, rare‐earth (RE) metal‐based catalysts have been successfully employed in this flourished area, demonstrating unique selectivity and complementary reactivity with respect to late‐transition metal‐catalyzed C−H functionalization. The development of rare‐earth metal‐catalyzed C−H functionalization by taking the advantage of these characteristic properties is of great importance and interest. Herein, a panorama of rare‐earth metal‐catalyzed C−H functionalization during the last decade is presented.
Advantages of Producing Aromatics from Propene over Ethene Using Zeolite‐Based Catalysts
Authors: Butolia Paresh S. , Xi Xiaoying , Winkelman Jozef G. M. , Stuart Marc C. A. , van Akker Matthijs , Heeres André , Heeres Hero Jan , Xie Jingxiu 
Published: October 2022

AbstractSustainable production of aromatics, especially benzene, toluene and xylenes (BTX), is essential considering their broad applications and the current global transition away from crude oil utilization. Aromatization of lower olefins, particularly ethene and propene, offers great potential if they are derived from more circular alternative carbon feedstocks such as biomass and waste plastics. This work aims to identify the preferred olefin feed, ethene or propene, for BTX production in a fixed‐bed reactor. A commercial H‐ZSM‐5 (Si/Al = 23) catalyst was used as a reference catalyst, as well as a Ga‐ZSM‐5 catalyst, prepared by Ga ion‐exchange of the H‐ZSM‐5 catalyst. At 773 K, 1 bar, 45 vol % olefin, 6.75 h−1, propene aromatization over the Ga‐ZSM‐5 catalyst exhibited higher BTX selectivity of 55 % and resulted in slower catalyst deactivation compared to ethene aromatization.
Burden of lymphedema in long‐term breast cancer survivors by race and age
Authors: Ren Yumeng , Kebede Michael A. , Ogunleye Adeyemi A. , Emerson Marc A. , Evenson Kelly R. , Carey Lisa A. , Hayes Sandra C. , Troester Melissa A. 
Published: October 2022

AbstractBackgroundRisk assessment for breast cancer–related lymphedema has emphasized upper‐limb symptoms and treatment‐related risk factors. This article examined breast cancer–related lymphedema after surgery, overall and in association with broader demographic and clinical features.MethodsThe Carolina Breast Cancer Study phase 3 followed participants for breast cancer–related lymphedema from baseline (on average, 5 months after breast cancer diagnosis) to 7 years after diagnosis. Among 2645 participants, 552 self‐reported lymphedema cases were identified. Time‐to‐lymphedema curves and inverse probability weighted conditional Cox proportional hazards model were used to evaluate whether demographics and clinical features were associated with breast cancer–related lymphedema.ResultsPoint prevalence of breast cancer–related lymphedema was 6.8% at baseline, and 19.9% and 23.8% at 2 and 7 years after diagnosis, respectively. Most cases had lymphedema in the arm (88%‐93%), whereas 14% to 27% presented in the trunk and/or breast. Beginning approximately 10 months after diagnosis, younger Black women had the highest risk of breast cancer–related lymphedema and older non‐Black women had the lowest risk. Positive lymph node status, larger tumor size (>5 cm), and estrogen receptor–negative breast cancer, as well as established risk factors such as higher body mass index, removal of more than five lymph nodes, mastectomy, chemotherapy, and radiation therapy, were significantly associated with increased hazard (1.5‐ to 3.5‐fold) of lymphedema.ConclusionsFindings highlight that hazard of breast cancer–related lymphedema differs by demographic characteristics and clinical features. These factors could be used to identify those at greatest need of lymphedema prevention and early intervention.Lay summary

In this study, the aim was to investigate breast cancer–related lymphedema (BCRL) burden.

This study found that risk of BCRL differs by race, age, and other characteristics.
Loss of tumor necrosis factor (TNF)‐receptor 1 and TNF‐receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus
Authors: Smilovic Dinko , Rietsche Michael , Fellenz Meike , Drakew Alexander , Vuksic Mario , Deller Thomas 
Published: October 2022

AbstractThe cytokine tumor necrosis factor (TNF) is involved in the regulation of physiological and pathophysiological processes in the central nervous system. In previous work, we showed that mice lacking constitutive levels of TNF exhibit a reduction in spine density and changes in spine head size distribution of dentate granule cells. Here, we investigated which TNF‐receptor pathway is responsible for this phenotype and analyzed granule cell spine morphology in TNF‐R1‐, TNF‐R2‐, and TNF‐R1/R2‐deficient mice. Single granule cells were filled with Alexa568 in fixed hippocampal brain slices and immunostained for the actin‐modulating protein synaptopodin (SP), a marker for strong and stable spines. An investigator blind to genotype investigated dendritic spines using deconvolved confocal image stacks. Similar to TNF‐deficient mice, TNF‐R1 and TNF‐R2 mutants showed a decrease in the size of small spines (SP−negative) with TNF‐R1/R2‐KO mice exhibiting an additive effect. TNF‐R1 mutants also showed an increase in the size of large spines (SP−positive), mirroring the situation in TNF‐deficient mice. Unlike the TNF‐deficient mouse, none of the TNF‐R mutants exhibited a reduction in their granule cell spine densities. Since TNF tunes the excitability of networks, lack of constitutive TNF reduces network excitation. This may explain why we observed alterations in spine head size distributions in TNF‐ and TNF‐R‐deficient granule cells. The changes in spine density observed in the TNF‐deficient mouse could not be linked to canonical TNF‐R‐signaling. Instead, noncanonical pathways or unknown developmental functions of TNF may cause this phenomenon.
Effects of Bi Alloying on the Thermoelectric Properties of p‐Type Mg3Sb2‐xBix Solid Solutions
Authors: Zhu Bo , Lu Xu , Li Jiadang , Xie Wenhao , Wang Lifei , Zhang Qiang , Fan Jianfeng , Zheng Yun 
Published: October 2022

AbstractBismuth is the most common alloying element for high‐performance Mg3Sb2‐based thermoelectric compounds. However, the electrical and thermal transport data is lacking for undoped Mg3(Sb, Bi)2 solid solutions. In this study, theoretical calculation results show that Bi alloying can reduce the band gap of Mg3Sb2, favoring the regulation of carrier concentration. Both Mg3Sb2 and Mg3SbBi compounds present a single band structure on the valence band maximum at Γ of the Brillouin zone. Incorporating the Bi element can slightly increase the density of states (DOS) on the valence band maximum, which is beneficial for the Seebeck coefficient. Mg3Sb2‐xBix (0≤x≤0.8) compounds were experimentally prepared via ball milling (BM) combined with the spark plasma sintering (SPS) technique. The carrier concentration, electrical conductivity, and power factor of the samples tend to increase with the increasing Bi content. Bismuth alloying significantly reduces the total thermal conductivity in the low‐temperature range, with the lowest value of 0.65 Wm−1K−1 obtained at ∼400 K for the x=0.2 sample. The peak ZT value of 0.077 at 800 K and the average ZT of 0.051 in the temperature range of 450–800 K are obtained for the x=0.2 sample, which is 93% and 219% higher than those of the unalloyed sample, respectively. This work reveals the Bi‐alloying induced transport mechanism and provides fundamental thermoelectric data regarding the undoped Mg3Sb2‐xBix (0≤x≤0.8) solid solutions.
Energy‐efficient and privacy‐preserving approach forInternet of Thingsnodes using a novel hybrid fuzzy water cycle and evaporation strategy and matrix‐based Rivest–Shamir–Adleman encryption algorithm
Authors: Dhavamani Logeshwari , Prem Priya P. 
Published: October 2022

SummaryThe Internet of Things (IoT) connects physical components all around the world via the internet and provides people with easy access. Even though IoT offers speedy operations, saves money, and provides automation and control, it suffers from different complexities such as data breaches, security issues, and load balancing. To overcome these complexities in the IoT environment, we propose a novel strategy to deal with energy consumption issues and offer a privacy‐preserving data transfer strategy. The proposed hybrid fuzzy water cycle and evaporation algorithm increases the lifetime of IoT networks by reducing the amount of energy required by massive IoT nodes and balancing traffic loads. To protect against malicious entries in cloud servers, the digital data block that is transported to be stored in the cloud is encrypted using the matrix‐based RSA encryption technique. The significance of the proposed methodology is proven by simulated results that compare it to state‐of‐the‐art methodologies in terms of security, system cost, resource utilization, and energy consumption. The resource utilization of this proposed methodology is 100% and the security level is 96%.
Stress wave propagation and incompatible deformation mechanisms in rock discontinuity interfaces in deep‐buried tunnels
Authors: Zhang Cong , Zhu Zhende , Wang Shanyong , Ren Xuhua , Shi Chong 
Published: October 2022

AbstractComplex weak structural planes and fault zones induce significant heterogeneity, discontinuity, and nonlinear characteristics of a rock mass. When an earthquake occurs, these characteristics lead to extremely complex seismic wave propagation and vibrational behaviors and thus pose a huge threat to the safety and stability of deep buried tunnels. To investigate the wave propagation in a rock mass with different structural planes and fault zones, this study first introduced the theory of elastic wave propagation and elastodynamic principles and used the Zoeppritz equation to describe wave field decomposition and develop a seismic wave response model accordingly. Then, a physical wave propagation model was constructed to investigate seismic waves passing through a fault, and dynamic damage was analyzed by using shaking table tests. Finally, stress wave attenuation and dynamic incompatible deformation mechanisms in a rock mass with fault zones were explored. The results indicate that under the action of weak structural planes, stress waves appear as a complex wave field decomposition phenomenon. When a stress wave spreads to a weak structural plane, its scattering may transform into a tensile wave, generating tensile stress and destabilizing the rock mass; wave dynamic energy is absorbed by a low‐strength rock through wave scattering, which significantly weakens the seismic load. Wave propagation accelerates the initiation and expansion of internal defects in the rock mass and leads to a dynamic incompatible deformation. This is one of the main causes for large deformation and even instability within rock masses. These findings provide an important reference and guide with respect to stability analysis of rock mass with weak structural planes and fault zones.
Dopant‐free passivating contacts for crystalline silicon solar cells: Progress and prospects
Authors: Wang Yanhao , Zhang Shan‐Ting , Li Le , Yang Xinbo , Lu Linfeng , Li Dongdong 
Published: October 2022

AbstractThe evolution of the contact scheme has driven the technology revolution of crystalline silicon (c‐Si) solar cells. The state‐of‐the‐art high‐efficiency c‐Si solar cells such as silicon heterojunction (SHJ) and tunnel oxide passivated contact (TOPCon) solar cells are featured with passivating contacts based on doped Si thin films, which induce parasitic optical absorption loss and require capital‐intensive deposition processes involving flammable and toxic gasses. A promising solution to tackle this problem is to employ dopant‐free passivating contact, involving the use of transparent and cost‐effective wide band gap materials. In this review, we first introduce the dopant‐free passivating contact, from carrier transport mechanisms, material classification to evaluation methods. Then we focus on the advances in different strategies to improve cell performance, including material property optimization, structural and interfacial engineering, as well as various post‐treatments. At the end, the challenge and perspective of dopant‐free passivating contact c‐Si solar cells are discussed.image
Fossil footprints and what they mean for hominin paleobiology
Authors: Hatala Kevin G. , Roach Neil T. , Behrensmeyer Anna K. 
Published: October 2022

AbstractHominin footprints have not traditionally played prominent roles in paleoanthropological studies, aside from the famous 3.66 Ma footprints discovered at Laetoli, Tanzania in the late 1970s. This contrasts with the importance of trace fossils (ichnology) in the broader field of paleontology. Lack of attention to hominin footprints can probably be explained by perceptions that these are exceptionally rare and “curiosities” rather than sources of data that yield insights on par with skeletal fossils or artifacts. In recent years, however, discoveries of hominin footprints have surged in frequency, shining important new light on anatomy, locomotion, behaviors, and environments from a wide variety of times and places. Here, we discuss why these data are often overlooked and consider whether they are as “rare” as previously assumed. We review new ways footprint data are being used to address questions about hominin paleobiology, and we outline key opportunities for future research in hominin ichnology.
Advances in upconversion luminescence nanomaterial‐based biosensor for virus diagnosis
Authors: Ma Yingjin , Song Menglin , Li Lihua , Lao Xinyue , Wong Man‐Chung , Hao Jianhua 
Published: October 2022

AbstractVarious infectious viruses have been posing a major threat to global public health, especially SARS‐CoV‐2, which has already claimed more than six million lives up to now. Tremendous efforts have been made to develop effective techniques for rapid and reliable pathogen detection. The unique characteristics of upconversion nanoparticles (UCNPs) pose numerous advantages when employed in biosensors, and they are a promising candidate for virus detection. Herein, this Review will discuss the recent advancement in the UCNP‐based biosensors for virus and biomarkers detection. We summarize four basic principles that guide the design of UCNP‐based biosensors, which are utilized with luminescent or electric responses as output signals. These strategies under fundamental mechanisms facilitate the enhancement of the sensitivity of UCNP‐based biosensors. Moreover, a detailed discussion and benefits of applying UCNP in various virus bioassays will be presented. We will also address some obstacles in these detection techniques and suggest routes for progress in the field. These progressions will undoubtedly pose UCNP‐based biosensors in a prominent position for providing a convenient, alternative approach to virus detection.
Diagnostic relevance of 2‐[18F]‐FDG PET/CT in patients recently diagnosed with monoclonal gammopathy of undetermined significance
Authors: Rudolphi‐Solero Teodoro , Triviño‐Ibáñez Eva María , González‐Jiménez Antonio Daniel , Ramos‐Font Carlos , Ríos‐Tamayo Rafael , Rebollo‐Aguirre Angel Custodio , Sánchez‐Sánchez Rocío 
Published: October 2022

Abstract2‐[18F]‐FDG PET/CT is a useful diagnostic technique to assess bone and soft tissue disease in multiple myeloma (MM) but is not recommended by the International Myeloma Working Group for the evaluation of monoclonal gammopathy of undetermined significance (MGUS). The objective of this study was to evaluate the role of 2‐[18F]‐FDG PET/CT in the management of these patients. An observational retrospective study was conducted on 338 patients with MGUS who underwent 2‐[18F]‐FDG PET/CT. The mean age was 70.80 ± 11.84 years, and 69.2% of patients had cardiovascular risk factors. Patients were classified according to their progression risk (Mayo Clinic). The mean post‐diagnosis follow‐up was 8.35 ± 14.46 months. Pathological findings were recorded in 49 patients: 30 with myeloma bone lesions (15 in the initial study and 15 in follow‐up) and 19 with other neoplastic (n = 13) or pathologically significant findings (n = 6). Body mass index, monoclonal component rate (MCR) > 1 g/dL and ≥1 risk factors for MM were significant in univariate logistic regression analyses. The MCR emerged as the main predictor of a positive 2‐[18F]‐FDG PET/CT in adjusted multivariate regression analysis, with an area under the receiver operating characteristic curve of 0.785 and cutoff for optimal sensitivity/specificity of 1.0 ng/mL (71.4% sensitivity, 71.2% specificity). 2‐[18F]‐FDG PET/CT results correctly classify patients with MGUS and could improve the detection of bone lesions over existing techniques, with the additional possibility of detecting neoplastic processes. The best parameter to predict a positive 2‐[18F]‐FDG PET/CT was the MCR.