bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agenda 2030: um estudo de caso sobre os desafios da implementação do ODS 6 para o município de Pombal-PB
Authors: Santos Chrístian Inácio dos , Leite Michael Douglas Sousa , Medeiros Aline Carla de , Magalhães Thalita Sévia Soares de Almeida , Lavor Francisco Ivo Gomes de , Sousa Neto Odilon Lúcio de , Pires Benigna Catarina de Belchior , Gonçalves Anilton Jorge da Nóbrega , Sampaio Robson Leite , Medeiros Elania Cavalcante Cunha de , Silva Filho Valdeir Gonçalves da , Bandeira Pablo Sthefano Roque de Souza , Santos Kaio Luís de Azevêdo , Almeida Karla Estefanny de Lacerda , Nobre Kadydja Mayara Ramos , Victor Jefferson Thiago da Silva , Silva Glauber Iure Cardoso de Menezes , Oliveira Samara Nóbrega de , Marques Agilio Tomaz , Mendes Jéssica Ruana Lima 
Published: March 2022

A agenda 2030 é um compromisso assumido por mais de 190 nações, sendo um instrumento relevante para a promoção do desenvolvimento sustentável mundial e constituída por 17 objetivos, chamados de objetivos de desenvolvimento sustentável (ODS), os quais são desmembrados em 169 metas, onde dentro desses objetivos, a ODS 6 trata a respeito da Água Potável e Saneamento, dela se desdobra várias metas. Neste sentido, este artigo tem como objetivo analisar o alcance das metas 6.1, 6.2, 6.3 voltados para o município de Pombal no estado da Paraíba. Utilizou-se como metodologia um estudo de caso, com pesquisas documental e exploratória, bem como a análise comparativa. Os resultados mostraram que em relação a meta 6.1 o município possivelmente atingirá até 2030, com relação as metas 6.2 e 6.3 dificilmente alcançara, será preciso esforço, empenho do poder público para alcance dessas metas. Para o alcance de todas as metas da ODS 6 é necessário mais investimento nessas áreas, é importante que o poder público promova parcerias com a esfera privada, Organizações não governamentais e sociedade civil. Ressalta-se que investir em saneamento básico é investir em vários fatores como saúde, qualidade de vida da população e preservação ambiental da sociedade.
Isolamento e identificação de Brucella suis biotipo 1 em amostras de suíno (sus scrofa) procedentes do município de Cachoeira do Arari, Estado do Pará- Brasil.
Authors: Ampuero Naiana Fleury da Fonseca , Silva Sandro Patroca da , Pereira Washington Luiz Assunção , Benigno Raimundo Nonato Moraes , Carneiro Adriana Ribeiro , Aragão Andressa de Oliveira , Casseb Lívia Medeiros Neves , Nunes Bruno Tardelli Diniz , Casseb Alexandre do Rosário 
Published: March 2022

Este trabalho teve como objetivo, estudar os microrganismos presentes em lesões encontradas em vísceras de suínos provenientes do município de Cachoeira do Arari (Ilha do Marajó), comercializados na feira do Ver-o-Peso em Belém do Pará; realizou-se o isolamento, sequenciamento nucleotídico e inferência filogenética do material coletado. Houve crescimento positivo no caldo cérebro coração e ágar sangue e ausência de crescimento no ágar MacConkey. Na coloração de gram observou-se cocos gram negativos agrupados, e na coloração de Ziehl- Neelsen Modificado observou cocos agrupados corados em vermelho. Essas características de crescimento, assim como os resultados microscópicos observados, foram sugestivos e semelhantes às bactérias pertencentes ao gênero Brucella sp. Após um resultado sugestivo a Brucella spp, a amostra foi encaminhada para extração de DNA, e sequenciamento nucleiotideo. Houve a identificação de Brucella suis biovar 1; com posterior montagem da árvore filogenética. Além da questão sanitária, o abate clandestino envolve ainda a questão ambiental, pois geralmente é realizado em locais próximos a rios ou córregos para facilitar a captação de água. A identificação de bactérias com características morfológicas semelhantes ao gênero Brucella do abscesso de suíno observado neste estudo, confirma que o animal apresentava brucelose suína e que abatedouros clandestinos podem ser importantes meios de infecção e disseminação desse agente, se não houver fiscalização que garantam a utilização de medidas de vigilância sanitária de qualidade que venham impedir esse tipo de prática e a venda do produto para o consumo humano.
A efetividade do plasma convalescente no tratamento da COVID-19: revisão sistemática
Authors: Santos Marcia Rodrigues dos , Bridi Adriana Carla , Louro Thiago Quinellato , Carvalho Márglory Fraga de , Carvalho Tatiana Santos de , Silva Roberto Carlos Lyra da , Silva Carlos Roberto Lyra da 
Published: March 2022

O objetivo desta revisão foi analisar a efetividade terapêutica do plasma convalescente utilizado em pacientes com confirmação de diagnóstico de COVID-19. Métodos: Trata-se de uma revisão sistemática de literatura, proposta no Manual da Cochrane Collaboration, com elaboração da estratégia PICO, na qual se utilizou as bases de dados Pubmed/Medline, BVS, Embase, CINAHL, LILACS, Cochrane e Google Scholar. Foram selecionados estudos do tipo ensaio clínico randomizado e revisões sistemáticas. Encontrou-se 1249 artigos, aplicando os critérios de inclusão e exclusão, selecionou-se 8 artigos. Para avaliação do risco de viés foi utilizado o AMSTAR-2 e para qualidade do conjunto da evidência dos estudos incluídos na revisão sistemática foi avaliada pelo Grading of Recommendations Assessment Development and Evaluation (GRADE). Resultados: Quanto aos resultados, predominaram estudos com baixo nível de evidência Oxford (75%). Quatro estudos (50%) apresentaram nível de evidência 2B. Uma resposta para essa análise foi a baixa qualidade da evidência e pouca confiança nos resultados dos estudos. A síntese qualitativa revelou que embora fosse capaz de reduzir a carga viral o uso do plasma convalescente não contribui isoladamente para a redução da carga. Conclusão: Verificou-se que o plasma convalescente é efetivo para a redução da carga viral, todavia são necessários mais estudos, particularmente análise custo-efetividade (ACE), por se tratar de uma tecnologia barata e com potencial de incorporação no SUS.
Influence of chromated copper arsenate type-C concentration on the quality of treated fence posts
Authors: Brito Thawane Rodrigues , Guedes David Pessoa , Silva José Reinaldo Moreira da , Baraúna Edy Eime Pereira , Paes Juarez Benigno 
Published: March 2022

This study aimed to reduce the concentration of chromated copper arsenate type-C (CCA-C) in preservative treatments of Eucalyptus sp. for use in applications with ground contact. The genetic materials used were Eucalyptus cloeziana of seminal origin and the clonal hybrid (E. urophylla x E. camaldulensis), which was derived from six year old crops at commercial plantations. The basic density, moisture content, percentage of sapwood, and wood treatable volume were determined, and the anatomical structures were characterized. The genetic materials were treated with concentrations of 1.2%, 1.3%, 1.4%, 1.5%, and 1.6% active ingredients (AI) of CCA-C. The quality of the preservative treatment was evaluated via penetration and retention tests. The treated wood volume of E. cloeziana exhibited 44% irregular partial penetration, 40% vascular penetration, 12% peripheral partial penetration, and 4% no penetration. For the hybrid, the wood volume exhibited 68% total penetration, 24% peripheral partial penetration, and 8% irregular partial penetration. The concentrations of 1.4% AI and 1.5% AI for E. cloeziana and of 1.4% AI and 1.6% AI for hybrid reached the minimum retention required by standard.
Overexpression of Head date 1 gene (Hd1): an adaptation of antarctic hairgrass to guano input from Macronectes giganteus colonies of Antarctica
Authors: Pereira Clarissa Kappel , Minozzo Mônica Munaretto , Aver Gustavo Francisco , Pereira Antonio Batista , Laindorf Bruna Lucia , Rosa Lurdes Zanchetta da , Petry Maria Virginia 
Published: March 2022

The Antarctic biodiversity, beyond the species composition, also comprises interactions between fauna and flora. M. giganteus, is one of the species that occupy the antarctic ice-free areas for reproduction. The moss Sanionia uncinata (Hedw.) Loeske and Deschampsia antarctica Desv. gress, common in Antarctica, with other species make up vast green formations and is associated with breeding areas of seabirds. These sites are large deposits of guano, because a large amount of birds those gather in colonies. Due to this large supply of guano, the soil becomes a deposit of minerals, mainly of nitrogen available in the form of ammonium and nitrate. The problem is that not all plant species tolerate high quantities of these substances so different plant species show trends in the mechanisms of tolerance to stress by ammonium, which have been proven at the molecular level. The aim of this study was to investigate the influence of breeding colonies of seabirds on plant populations in the South Shetland Islands, Antarctica, from a molecular perspective. From the analysis of the collected samples, using the RNA-Seq and qRT-PCR approach was possible to identify a single gene differential and significantly expressed in D. antarctica. The LOC_Os06g16380 gene among the sampled treatments (control, 1m and 10m), showed higher expression coming 1m near breeding areas of M. giganteus. Our results suggest that Hd1 is associated with the plants stress related to guano input since that soil analysis demonstrated a higher concentration of mineral nitrogen available near of breeding areas of seabirds.
Análise físico-química da água de poços em uma área urbana de ocupação irregular na Amazonia Brasileira
Authors: Melo Sérgio Gouvêa de , Ribeiro Joseph Simões , Lopes Ruy Bessa , Moura Lucinewton Silva de , Silva Júlio Tota da 
Published: March 2022

Os recursos hídricos são de suma importância na manutenção da vida e saúde humana e, sua qualidade pode ser deteriorada conforme o avanço de ocupações irregulares, podendo contaminar os recursos hídricos subterrâneos. No Brasil o Ministério da Saúde tem portarias que balizam parâmetros para a potabilidade da água subterrânea para consumo humano. Assim o objetivo deste trabalho é avaliar a qualidade da água de poços na Ocupação Vista Alegre do Juá no município de Santarém por meio da Portarias 888/21 do Ministério da Saúde e 396/08 Conama. As amostras foram coletadas em três poços do tipo tubular, a fim de avaliar 12 parâmetros físico-químicos, comparando os resultados com os padrões preestabelecidos pela legislação vigente. Os três poços analisados, apresentaram três dos 12 analisados parâmetros analisados fora do permitido pela legislação, sendo eles: fósforo, nitrato e turbidez, com exceção do poço três para este último parâmetro. Essas alterações estão principalmente relacionadas a decomposição de raízes de árvores provenientes do recente desmatamento e o fluxo natural das chuvas que carreiam nutrientes de áreas mais altas para as mais baixas, onde se encontram os poços. Os parâmetros citados tornam imprópria a água para o consumo sem tratamento e tem efeitos sobre sua palatabilidade, conferindo propriedades laxantes e outros riscos à saúde se consumidos por longos períodos sem o devido tratamento. Assim, este estudo destaca a necessidade avaliar mais poços e dar suporte aos moradores sobre a utilização de métodos de desinfecção da água antes de seu consumo para evitar doenças de veiculação hídrica.
ANALISIS POTENSI DAERAH RAWAN ABRASI PANTAI BERDASARKAN PARAMETER FISIKA OSEANOGRAFI DI PESISIR UTARA DAN TIMUR LAUT PULAU WAWONII, SULAWESI TENGGARA
Authors: Hartomo La Ode Ibnu , Asmadin . , Pratikino A. Ginong 
Published: March 2022

Berdasarkan data risiko bencana Kabupaten Konawe Kepulauan pada kawasan rawan abrasi terdapat tiga dari tujuh kecamatan di pulau seluas 650 Km2 telah mengalami abrasi yang membuat garis pantai semakin menjauh ke darat. Tujuan penelitian ini yaitu untuk mengetahui karakteristik pantai, kondisi parameter Fisika Oseanografi serta mengetahui potensi daerah rawan abrasi pantai di pesisir Utara dan Timur Laut Pulau Wawonii. Pengambilan data dilaksanakan pada bulan Agustus 2020 bertempat di perairan pesisir pantai Wawonii Utara dan Timur Laut Konawe Kepulauan dengan 4 titik stasiun. Metode penelitian untuk mengetahui karakteristik pantai dan potensi daerah rawan abrasi pantai menggunakan metode pembobotan atau scoring. Kondisi parameter fisika oseanografi berupa gelombang dan arus menggunakan metode peramalan gelombang berdasarkan data arah dan kecepatan angin bersumber dari ECMWF. Hasil penelitian menunjukkan bahwa pada kedua lokasi studi memiliki tipe substrat yang sama yaitu berpasir, keseluruhan bentuk pantai relatif datar, dan jarang atau tidak ditemukannya habitat mangrove. Perairan Wawonii Utara memiliki tinggi gelombang signifikan relatif lebih kecil yaitu 0.54 m dengan periode 4.29 s. Perairan Wawonii Timur Laut menunjukkan tinggi gelombang signifikan sebesar 3.17 m dengan periode gelombang 11.52 s. Kedua perairan memiliki tipe arus sejajar pantai (longshore current). Pada Wawonii Utara kedua titik lokasinya memiliki tingkat kerawanan abrasi dalam kategori sedang dengan skor nilai 13 dan 15 sedangkan pada Wawonii Timur Laut termasuk dalam kategori tinggi dengan skor nilai masing-masing 17 dan 17.Kata Kunci: Wilayah Pesisir, abrasi, Daerah Rawan Abrasi, Fisika Oseanografi, Pulau Wawonii
POLA ARUS PERMUKAAN LAUT DI BAGIAN TERLUAR TELUK KENDARI DAN PERAIRAN SEKITARNYA
Authors: Nurlin . , Asmadin . , Takwir Amadhan 
Published: March 2022

permukaan umumnya bersumber dari gerakan angin. Penelitian ini bertujuan untuk mengetahui pengaruh angin terhadap pergerakan arus permukaan di bagian terluar Teluk Kendari dan Perairan sekitarnya pada musim yang berbeda. Data yang dikumpulkan pada penelitian ini terdiri dari 2 jenis data yaitu data primer meliputi data arus dan angin serta data sekunder meliputi data pasang surut. Metode penelitian untuk mengukur kecepatan arus permukaan menggunakan metode Euler. Metode untuk memperhitungkan nilai dan arah kecepatan angin menggunakan metode Wind Rose. Metode untuk memperhitungkan gerak osilasi pasang surut secara periodik menggunakan Metode Admiralty. Hasil penelitian menunjukkan bahwa pola pergerakan arus permukaan laut di bagian terluar Teluk Kendari dan Perairan sekitarnya pada setiap musimnya memiliki nilai kecepatan arus laut permukaan tertinggi terjadi pada musim timur yaitu 0.26 m/s dengan arah dari Timur menuju ke Barat dan nilai terendah terjadi pada musim peralihan II yaitu 0.01 m/s dengan arah dari Barat menuju ke Timur. Perubahan arah dan kecepatan angin di bagian terluar Teluk Kendari dan Perairan sekitarnya tidak memberikan pengaruh sepenuhnya terhadap perubahan arah dan kecepatan arus permukaan pada setiap musimnnya. Selain angin diduga ada faktor lain yang memengaruhi perubahan arah dan kecepatan arus permukaan, seperti pasang surut, gaya coriolis dan bentuk topografi pada Perairan Teluk Kendari bagian luar dan sekitarnya.Kata Kunci:, Arus, Angin, Pasut, Teluk Kendari
c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease
Authors: Marín Tamara , Dulcey Andrés E. , Campos Fabián , de la Fuente Catalina , Acuña Mariana , Castro Juan , Pinto Claudio , Yañez María José , Cortez Cristian , McGrath David W. , Sáez Pablo J. , Gorshkov Kirill , Zheng Wei , Southall Noel , Carmo-Fonseca Maria , Marugán Juan , Alvarez Alejandra R. , Zanlungo Silvana 
Published: March 2022

Niemann-Pick type A (NPA) disease is a fatal lysosomal neurodegenerative disorder caused by the deficiency in acid sphingomyelinase (ASM) activity. NPA patients present severe and progressive neurodegeneration starting at an early age. Currently, there is no effective treatment for this disease and NPA patients die between 2 and 3 years of age. NPA is characterized by an accumulation of sphingomyelin in lysosomes and dysfunction in the autophagy-lysosomal pathway. Recent studies show that c-Abl tyrosine kinase activity downregulates autophagy and the lysosomal pathway. Interestingly, this kinase is also activated in other lysosomal neurodegenerative disorders. Here, we describe that c-Abl activation contributes to the mechanisms of neuronal damage and death in NPA disease. Our data demonstrate that: 1) c-Abl is activated in-vitro as well as in-vivo NPA models; 2) imatinib, a clinical c-Abl inhibitor, reduces autophagy-lysosomal pathway alterations, restores autophagy flux, and lowers sphingomyelin accumulation in NPA patient fibroblasts and NPA neuronal models and 3) chronic treatment with nilotinib and neurotinib, two c-Abl inhibitors with differences in blood-brain barrier penetrance and target binding mode, show further benefits. While nilotinib treatment reduces neuronal death in the cerebellum and improves locomotor functions, neurotinib decreases glial activation, neuronal disorganization, and loss in hippocampus and cortex, as well as the cognitive decline of NPA mice. Our results support the participation of c-Abl signaling in NPA neurodegeneration and autophagy-lysosomal alterations, supporting the potential use of c-Abl inhibitors for the clinical treatment of NPA patients.
Clinical Characteristics and Long-Term Outcomes of Patients With Differing Haemoglobin Levels Undergoing Semi-Urgent and Elective Percutaneous Coronary Intervention in an Asian Population
Authors: Soh Rodney Yu-Hang , Sia Ching-Hui , Djohan Andie Hartanto , Lau Rui-Huai , Ho Pei-Ying , Neo Jonathan Wen-Hui , Ho Jamie Sin-Ying , Sim Hui-Wen , Yeo Tiong-Cheng , Tan Huay-Cheem , Chan Mark Yan-Yee , Loh Joshua Ping-Yun 
Published: March 2022

IntroductionThis study aimed to investigate the impact of anaemia on long-term clinical outcomes in patients who underwent semi-urgent and elective percutaneous coronary intervention (PCI) in an Asian population. Although the effects of anaemia on outcomes in Asian patients are well studied for acute coronary syndrome, its impact on Asian patients undergoing semi-urgent and elective PCI is unclear.MethodsThis was a retrospective cohort study of patients who underwent semi-urgent and elective PCI from January 1, 2014, to December 31, 2015, at a tertiary academic centre. A total of 1,685 patients were included. They were stratified into three groups: normal (≥12 g/dL), intermediate (10–11.9 g/dL), and low (&lt;10 g/dL) haemoglobin levels. Demographics, risk factors, and end-points including the 5-point major adverse cardiac and cerebrovascular events (MACCE) (all-cause death, subsequent stroke, myocardial infarction, congestive cardiac failure, and target lesion revascularisation), cardiovascular death, and bleeding events were analysed.ResultsPatients in intermediate and low haemoglobin level groups were older with more comorbidities. Compared to the normal haemoglobin level group, low haemoglobin level group patients were associated with an increased risk of composite endpoints of all-cause death, subsequent stroke, myocardial infarction, congestive cardiac failure, and target lesion revascularisation [adjusted hazard ratio (aHR) 1.89, 95% confidence interval (CI):1.22, 2.92; p = 0.004]. This was driven by the increased risk of target lesions revascularisation observed in the low haemoglobin level group compared to the normal haemoglobin level group (aHR 17.74, 95% CI: 1.74, 180.80; p = 0.015). The patients in the low haemoglobin level group were also associated with a higher risk of bleeding events compared to the normal haemoglobin level group (aHR 7.18, 95% CI: 1.13, 45.40; p = 0.036).ConclusionIn our Asian cohort, patients with anaemia undergoing PCI were associated with a higher comorbid burden. Despite adjustments for comorbidities, these patients had higher mortality and worse cardiovascular outcomes following contemporary PCI.
The Long-Term Effects of Non-Pharmacological Interventions on Diabetes and Chronic Complication Outcomes in Patients With Hyperglycemia: A Systematic Review and Meta-Analysis
Authors: Zhou Rongrong , Cui Yashan , Zhang Yuehong , De Jin , An Xuedong , Duan Yingying , Zhang Yuqing , Kang Xiaomin , Lian Fengmei 
Published: March 2022

ObjectiveThis study aimed at examining the long-term effects of non-pharmacological interventions on reducing the diabetes incidence among patients with prediabetes and chronic complications events among patients with hyperglycemia (pre-diabetes and diabetes) by performing a systematic review and meta-analysis of randomized controlled trials (RCTs).MethodsPubMed, MEDLINE, EMBASE, the Cochrane Library, and the Web of Science Core Collection were searched for studies published between January 1990 and November 2021, looking for RCTs to evaluate the effects of non-pharmacological interventions on preventing the incidence of diabetes and chronic complications in comparison with medical therapy, placebo, or usual diabetes care. Two independent reviews extracted relevant data and quality assessment. Any discrepancies were resolved by a third reviewer.ResultsIn total, 20 articles involved 16 RCTs (follow-up ranged from 2 to 30 years) were included. Pooled analysis of intervention studies demonstrated clearly that non-pharmacological interventions have a significant effect on reducing the diabetes events in patients with prediabetes (RR 0.62; 95% CI 0.54, 0.71). Pooled analysis of extended follow-up studies showed that non-pharmacological interventions could effectively reduce the diabetes incidence in patients with prediabetes (RR 0.78; 95% CI 0.63, 0.96). Meta-regression and subgroup analysis indicates that the diabetes incidence of the long-term group (duration &gt; 3 years) was clearly reduced by 0.05% compared with the relatively short-term group (duration ≤ 3 years). The incidence of microvascular complications in patients with hyperglycemia was effectively lowered by non-pharmacological interventions (RR 0.60; 95% CI 0.43, 0.83).ConclusionNon-pharmacological interventions have a long-term effect on reducing the diabetes incidence among prediabetic patients and effectively preventing microvascular complications on hyperglycemia.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/.
Heat Transfer Characteristics and Pressure Drop of U-type Channel in Vacuum Distillation Process for Titanium Sponge
Authors: Yang Kangquan , Zhang Chengqi , Yuan Hui , Wu Fuzhong 
Published: March 2022

Blockage of the U-type channel exacerbates the intermittency of production, and clarifying the channel heat transfer characteristics and pressure drop is an effective way to address this problem. The channel heat transfer and flow characteristics of the fluid in the channel are experimentally investigated in this study. According to the experiments, the heat transfer coefficient is between 59.95 and 200.29 W/m2⋅K and increases with the flow velocity and fluid temperature. Because the pressure drop is usually accompanied by a change in the energy loss of the fluid, the energy loss is evaluated experimentally. The results demonstrate that the friction loss in the straight tube section accounts for 80% of the energy loss. A bent tube of 90° is recommended instead of a right-angle tube to reduce the pressure drop. A dimensionless relation regarding the Nusselt number is presented to predict the heat transfer characteristics. We provided proposals to address the problem of blockage of the U-type channel, this is helpful to reduce production energy consumption and improve the quality of titanium sponge.