bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resistant PRL-secreting PitNET associated with breast carcinoma: a case report and literature review
Authors: Dumitriu-Stan Roxana-Ioana , Burcea Iulia-Florentina , Nastase Valeria Nicoleta , Ceausu Raluca Amalia , Raica Marius , Poiana Catalina 
Published: January 2025

AbstractIn several studies, hyperprolactinemia has been associated with increased breast cancer risk. Evidence shows that prolactin (PRL) is linked to mammary tumorigenesis, especially in postmenopausal patients, but the data remain controversial. We present a case of a 67 year-old patient with a resistant PRL-secreting PitNET who subsequently developed breast cancer. The patient was known to have persistent high PRL levels despite multimodal treatment (surgery, radiotherapy, and high doses of cabergoline). The tumor specimens obtained after transsphenoidal intervention were histologically and immunohistochemically examined for the following parameters: anterior pituitary hormones, the ki-67 labeling index, CAM 5.2 expression, ER ∝ expression, and somatostatin receptors, which revealed a densely granulated tumor with intense positivity for PRL and ER ∝ , a ki-67 labeling index of 6% and negative MGMT expression. Years later, the patient was diagnosed with breast carcinoma. Histopathological and immunohistochemical examination of the tumor specimen obtained after radical mastectomy confirmed ductal invasive breast cancer with negative immunostaining for prolactin receptors (PLRr) but positive immunostaining for estrogen (ER) and progesterone receptors (PGR) and a ki-67 labeling index of 8%. PRL is involved in mammary development and differentiation, which leads to lactation, the major driver during pregnancy, by regulating ovarian progesterone production. On the basis of the physiological actions of PRL, a role for this hormone in breast cancer has been suggested. Few cases of different types of breast carcinoma associated with hyperprolactinemia due to a pituitary tumor have been reported in the literature. The association between hyperprolactinemia and the risk of breast carcinoma is not well understood. Immunohistochemistry evaluation of PLRr can be helpful to provide information in these cases.
Mathematical modelling of hydrotreating of Kazakhstan and west Siberian vacuum gas oil mixtures
Authors: Vorobev Anatoliy , Ivashkina Elena N. , Arkenova Saniya B. , Kaliyev Toleubek A. 
Published: January 2025

Abstract
A numerical model for practical simulation of hydrotreatment of vacuum gas oil in a trickle-bed reactor is developed. The model is based on the mass balance of species; it incorporates a seven-lump chemical scheme that describes the reactions of hydrodesulphurisation and hydrodearomatisation, the accuracy of calculations using the model is no less than 93.7%. The novelty of the model is splitting of sulphur-containing compounds into different lumps by their reactive abilities. The splitting is supported by the chromatographic analysis of hydrocarbon mixtures that are sampled from the inlet and outlet ends of an industrial hydrotreatment unit. The analysis reveals different susceptibilities of sulphides, benzothiophene, and dibenzothiophenes to hydrotreatment. The new model is applied for simulation of the hydrotreatment at a refinery, adjusting kinetic parameters, and demonstrating that the model provides an adequate (and, at the same time, simple) description of the process, giving guidance for optimisation that is needed after each variation of the feedstock. Using the kinetic model, it is found that an increase in temperature from 330 to 390 °C leads to a decrease in the content of aromatic compounds in hydrotreated vacuum gas oil by 20.75%, and sulphur compounds by 92%. It has been established that an increase in the hydrogen consumption from 50,000 to 90,000 nm3/h leads to a decrease in the sulphur content in the product by 3%. When the feedstock consumption rise from 100 to 150 m3/h, the desulphurization depth decreases by 6.5%.
Causal discovery and fault diagnosis based on mixed data types for system reliability modeling
Authors: Wang Xiaokang , Jiang Siqi , Li Xinghan , Wang Mozhu 
Published: January 2025

Abstract
Causal relationships play an irreplaceable role in revealing the mechanisms of phenomena and guiding intervention actions. However, due to limitations in existing frameworks regarding model representations and learning algorithms, only a few studies have explored causal discovery on non-Euclidean data. In this paper, we address the issue by proposing a causal mapping process based on coordinate representations for heterogeneous non-Euclidean data. We propose a data generation mechanism between the parent nodes and the child nodes and create a causal mechanism based on multi-dimensional tensor regression. Furthermore, within the aforementioned theoretical framework, we propose a two-stage causal discovery approach based on regularized generalized canonical correlation analysis. Using the discrete representation in the shared projection direction, causal relationships between heterogeneous non-Euclidean variables can be discovered more accurately. Finally, empirical research is conducted on real-world industrial sensor data, which demonstrates the effectiveness of the proposed method for discovering causal relationships in heterogeneous non-Euclidean data.
A New Approach: Using Biometric Technology to Explore the Physiological Stress of Working in Child Welfare
Authors: Griffiths Austin , Link Kim , Haughtigan Kara , Beer Oliver W. J. , Powell Lindsey , Royse David 
Published: January 2025

AbstractJob stress among child welfare professionals affects their mental and physical health and is associated with negative outcomes. Researchers have used self-report measures to document the stress experienced by those in the child welfare field, and this is the first study to use biometric technology across 72 h to identify physiological indicators of stress, recovery, and sleep in frontline child welfare workers in mostly rural areas (n = 32). A stress profile of the participants is presented on their heart rates, mean time-stressed, percent of time stressed, mean time relaxed, percent of time relaxed, mean sleep time, mean RMSSD in sleep, and body mass index (BMI). Variables were also examined by length of employment with the agency. Results indicate participants averaged nearly 16 h of physiological stress per day and were unable to spend much time in relaxation or recovery from stress. Stress appeared ubiquitous and possibly difficult to manage.
Harmonious ageing: a narrative review of music therapy in the biomedical literature
Authors: Raja Shaz , Barry Ciara , Upadhyay Rohit , Alash Rana , O’Raghallaigh Méabh , Hayes Róisín , Romero-Ortuno Roman 
Published: January 2025

Abstract
Purpose
As the global population of older adults rises, the United Nations Decade of Healthy Ageing (2021–2030) advocates for disease prevention, management, and enhancing overall wellbeing in older adults. We reviewed the MEDLINE literature under the MeSH term “music therapy” (MT), for its role in promoting healthy ageing.

Methods
A systematic search of the MEDLINE biomedical database (Ovid) was conducted using “MT” and “Ageing” as keywords, retrieving relevant full-text studies in English. Preference was given to more recent studies with higher levels of evidence. The studies were categorised according to the biopsychosocial framework into physical, cognitive and social domains, and further subcategorised based on their relevance to disease prevention and management.

Results
The initial search identified 1147 articles, of which 75 met inclusion criteria. Studies encompassed both MT and music interventions delivered by non-music therapists. Overall, studies showed benefits in the promotion of physical health, including enhancing exercise capacity and improving fitness among older adults. Results were promising in managing conditions such as Parkinson’s disease and frailty. In the area of brain health, studies showed cognitive benefits, particularly in attention and processing speed among older adults. Socially, there was evidence of enhanced quality of life, reduced anxiety and depression, and improved social engagement, including in people living with dementia, underscoring the role of music in fostering emotional connections and mitigating caregiver stress.

Conclusion
MT and interventions can enhance biopsychosocial health outcomes in older adults. Research should prioritise isolating MT’s specific effects, standardising definitions and methodologies, and exploring therapeutic mechanisms.
Hydrocephalus as a Rare Presentation of Neurosarcoidosis—A Case Report
Authors: Stauning A. T. , Larsen C. C. , Holst A. V. 
Published: January 2025

AbstractNeurosarcoidosis represents a rare manifestation of sarcoidosis, with hydrocephalus occurring in only 5–9% of cases. A 56-year-old female presented with severe hydrocephalus. Initial management involved a third ventriculostomy. Subsequent diagnostic evaluations confirmed neurosarcoidosis. However, before initiating medical treatment, recurrent hydrocephalus required reopening of the third ventriculostomy. The patient is currently undergoing a therapeutic regimen comprising methotrexate and infliximab, and no new manifestations of hydrocephalus were observed following the reoperation. In cases where obstructive hydrocephalus is associated with neurosarcoidosis, the prompt initiation of steroid treatment is imperative. Delays may contribute to the risk of relapse, underscoring the importance of timely medical management.
Alternative Stewart Platform Configuration for the Enhanced Isolation of CMG-Induced Microvibration
Authors: Chung Bawoul , Lee Jong-Kuk , Song Tae-Seong , Song Deok-ki , Han Jae-Hung 
Published: January 2025

AbstractFor sensitive payloads in satellites, microvibration is a cause of significant performance degradation. The Control Moment Gyro (CMG), an attitude control device for agile satellites, generates microvibration due to imbalance and irregularities in its high-speed flywheel. As the satellite body transmits microvibration to the sensitive payloads due to its low damping characteristics, it is imperative to isolate microvibration at the source. In this study, a hexapod microvibration isolator based on the Stewart platform is proposed with an alternative configuration. This alternative configuration, originally proposed to reduce coupling transmissibility, is adopted to provide stable performance across a broad frequency range with less weight compared to the widely used cubic configuration in Stewart platform microvibration applications. Modal analysis showed that the alternative configuration is stiffer compared to the cubic configuration. The performance of the isolator was experimentally tested with a high-torque CMG. The proposed hexapod microvibration isolator with an alternative configuration successfully isolated microvibration from the CMG without severe performance degradation.
Microbe-mediated organic fertilization increases insect predator attraction upon fruit damage in olive trees
Authors: Aguirrebengoa Martin , Moreno Beatriz , Guirado Nuria , Núñez Rafael , Fernández-Sierra María L. , Reyes Fernando , Martín Jesús , Benítez Emilio 
Published: January 2025

Abstract

Revalorized olive waste impacts root microbiome.

Root microbiome modulates plant-induced defense.

Insect’s exudate simulates the pest attack.

The objective of this study was to investigate the combined effect of soil amendments and pest attack on plant-induced defense and their impact on a biological control agent’s behavior. The effects of olive mill wastes revalorized through vermicomposting on the aboveground tri-trophic interactions among olive trees (Olea europaea), the olive seed-feeder, Prays oleae, and its natural predator, Chrysoperla carnea, were evaluated. The findings demonstrate that soil nitrogen and organic carbon levels, in conjunction with fungal diversity and functionality within olive roots, exert a significant influence on the volatile compounds emitted by the plant under attack that are most appealing to C. carnea. Moreover, the attractiveness of aerial volatiles was found to correlate with soil organic carbon content and the taxonomic and functional diversity of both bacteria and fungi in the olive root system. It is worthy of note that three particular volatile compounds, namely 5-hepten-2-one-6-methyl, acetic acid and nonanal, were consistently observed to attract C. carnea. These findings highlight the potential of soil amendments to enhance biological control strategies. Future research should prioritise the validation the greenhouse findings through large-scale field trials and the assessment of the practical applications of soil amendments in pest management programmes.
COVID-19 Misbehavior During the Lockdown in Iran: An Extension of Situational Action Theory
Authors: Shadmanfaat Shamila , Kabiri Saeed , Wellen Hadley , Smith Hayden P. , Cochran John , Yousefvand Saman 
Published: January 2025

AbstractThere is a notable gap in research applying criminological theory to the examination of deviant behaviors during the COVID-19 pandemic. This study addresses this gap by utilizing Situational Action Theory (SAT) to investigate violations of social hygiene ordinances during a COVID-19 lockdown in Iran. The study is based on survey data collected from a sample of 396 university students across 10 universities in Rasht, Iran. The findings support SAT, demonstrating the relevance of its four theoretical components: personal morality, situational morality, self-control, and perceptual deterrence. Additionally, the study reveals significant multiplicative interactions between criminal propensity, criminal exposure, perceptions of action alternatives, and the process of choice. These factors were significantly linked to COVID-19 related misbehavior, offering valuable insights into individual decision-making processes when faced with criminogenic and health-related dilemmas.
Divergent models of soil organic carbon sequestration related to vegetation restoration
Authors: Deng Lei , Shangguan Zhouping 
Published: January 2025

AbstractLong-term vegetation restoration increases soil organic carbon (SOC) stock, while short-term vegetation restoration shows inconsistent results. This paper attempts to explore the short-term and long-term responses of SOC sequestration dynamics to vegetation restoration, and elucidate their influence mechanism, which can provide a theoretical basis for vegetation restoration.
Graphical Abstract
The Influence of Topography on the Global Terrestrial Water Cycle
Authors: Gnann Sebastian , Baldwin Jane W. , Cuthbert Mark O. , Gleeson Tom , Schwanghart Wolfgang , Wagener Thorsten 
Published: January 2025

AbstractTopography affects the distribution and movement of water on Earth, yet new insights about topographic controls continue to surprise us and exciting puzzles remain. Here we combine literature review and data synthesis to explore the influence of topography on the global terrestrial water cycle, from the atmosphere down to the groundwater. Above the land surface, topography induces gradients and contrasts in water and energy availability. Long‐term precipitation usually increases with elevation in the mid‐latitudes, while it peaks at low‐ to mid‐elevations in the tropics. Potential evaporation tends to decrease with elevation in all climate zones. At the land surface, topography is expressed in snow distribution, vegetation zonation, geomorphic landforms, the critical zone, and drainage networks. Evaporation and vegetation activity are often highest at low‐ to mid‐elevations where neither temperature, nor energy availability, nor water availability—often modulated by lateral moisture redistribution—impose strong limitations. Below the land surface, topography drives the movement of groundwater from local to continental scales. In many steep upland regions, groundwater systems are well connected to streams and provide ample baseflow, and streams often start losing water in foothills where bedrock transitions into highly permeable sediment. We conclude by presenting organizing principles, discussing the implications of climate change and human activity, and identifying data needs and knowledge gaps. A defining feature resulting from topography is the presence of gradients and contrasts, whose interactions explain many of the patterns we observe in nature and how they might change in the future.
Particulate Cadmium Accumulation in the Mesopelagic Ocean
Authors: Laubach A. , Lee J.‐M. , Sieber M. , Lanning N. T. , Fitzsimmons J. N. , Conway T. M. , Lam P. J. 
Published: January 2025

AbstractObservations of dissolved cadmium (dCd) and phosphate (PO4) suggest an unexplained loss of dCd to the particulate phase in tropical oxyclines. Here, we compile existing observations of particulate Cd and phosphorus (P), and present new data from the US GEOTRACES GP15 Pacific Meridional Transect to examine this phenomenon from a particulate Cd perspective. We use a simple algorithm to reproduce station depth profiles of particulate Cd and P via regeneration and possible subsurface accumulation. Our examination of regeneration reveals decoupling of particulate Cd and P driven by variable partitioning between two particulate pools with differing labilities. Further, we identify evidence for subsurface particulate Cd accumulation at 31 stations. Subsurface particulate Cd accumulation occurs most consistently in the mesopelagic tropical Pacific but can be found in all examined ocean basins. This accumulation is not well‐correlated with dissolved oxygen or particulate sulfide concentration. Instead, we observe that particulate Cd accumulation occurs in regions where the concentration of dCd is relatively high compared to dissolved zinc (dZn) and speculate that it is the result of enhanced dCd biological uptake in response to the subsurface micronutrient balance.
Inner Forearc Stress State and Plate Coupling
Authors: Sharma Viven , Wada Ikuko , Rippke Joe 
Published: January 2025

AbstractThe long‐term state of stress in the subduction forearc depends on the balance between margin‐normal compression due to the plate‐coupling force and the margin‐normal tension due to the gravitational force on the margin topography. In most subduction margins, the outer forearc is largely in margin‐normal compression due to the dominance of the plate‐coupling force. The inner forearc's state of stress varies within and among subduction zones, but what gives rise to this variation is unclear. We examine the state of stress in the forearc region of nine subduction zones by inverting focal mechanism solutions for shallow forearc crustal earthquakes for five zones and inferring the previous inversion results for the other four. The results indicate that the inner forearc stress state is characterized by margin‐normal horizontal deviatoric tension in parts of Nankai, Hikurangi, and southern Mexico. The vertical and margin‐normal horizontal stresses are similar in magnitudes in northern Cascadia as previously reported and are in a neutral stress state. The inner forearc stress state in the rest of the study regions is characterized by margin‐normal horizontal deviatoric compression. Tension in the inner forearc tends to occur where plate coupling is shallow. A larger width of the forearc also promotes inner‐forearc tension. However, regional tectonics may overshadow or accentuate the background stress state in the inner forearc, such as in Hikurangi.
A Laboratory‐Validated, Graph‐Based Flow and Transport Model for Naturally Fractured Media
Authors: Sutton Collin R. , Zahasky Christopher 
Published: January 2025

AbstractFractures are a primary feature controlling flow, transport, and coupled processes in geologic systems. To date, experimental image‐based observations of these processes have been challenging. Here, we use pulse‐tracer experiments with a conservative radiotracer ([18F]‐fludeoxyglucose) spanning multiple flow rates with simultaneous positron emission tomography imaging to characterize transport in a 5.08 cm fractured Sierra granite core. A graph‐based, laboratory‐validated flow and transport model is successfully demonstrated to describe the conservative solute transport in the natural fracture. Model network complexity, determined by the number of nodes and edges, significantly impacts model fit to observed data. Large graphs over‐describe a fracture plane and act similarly to a porous medium while small graphs oversimplify the solute transport behavior. To our knowledge, this work provides the first validation of graph‐based flow and transport models across a range of experimental conditions and sets the groundwork for upscaling to more complex and computationally efficient fracture models.
A Shorter Duration of the Indian Summer Monsoon in Constrained Projections
Authors: Cheng Yifeng , Wang Lu , Chen Xiaolong , Zhou Tianjun , Turner Andrew 
Published: January 2025

AbstractA reliable projection of the future duration of the Indian summer monsoon (ISM) provides an important input for climate adaptation in the Indian subcontinent. Nevertheless, there is low confidence for projections of ISM duration, due to large inter‐model uncertainty of onset and withdrawal changes. Here, we find that models with excessive sea surface temperature (SST) over the tropical western Pacific (WP) during spring and greater surface warming trends over the northern mid‐high latitudes (NMHL) during autumn in the present day tend to overestimate future delays to ISM onset and withdrawal, respectively. This can be attributed to the influence of surface thermal conditions on upper‐tropospheric warming patterns. Constrained by the observational WP SST and NMHL surface warming trends, projected ISM duration under a high‐emission scenario is shortened by 6 days compared to the current climate, with a reduction of inter‐model uncertainty by 46% relative to the unconstrained results.
Slip Modeling of Large Earthquakes by Joint Inversion of W‐Phase and Back‐Projected Images
Authors: Peng Yuyang , Wang Dun , Takeuchi Nozomu , Rivera Luis 
Published: January 2025

AbstractWe present a novel finite fault inversion algorithm that combines W‐phase finite fault inversion with Image Deconvolution Back‐Projection (IDBP) for the determination of coseismic slip models following large earthquakes. This integrated algorithm leverages the strengths of both methods, enabling rapid determination of moment tensor, slip distribution, and centroid location. The application of this integrated algorithm to the analysis of the 2015/04/25 Mw 7.8 Nepal and the 2013/01/05 Mw 7.5 Craig Alaska earthquakes yielded results closely aligned with detailed post‐earthquake studies, highlighting the algorithm's accuracy and reliability. By overcoming inherent limitations of individual methods, it provides a comprehensive understanding of the earthquake source process. The algorithm's potential for automated implementation, requiring few parameters, enhances its suitability for near real‐time earthquake analysis.