bluuebunny/crossref_metadata_2025_split huggingface dataset:
Culprit Lesion Morphology of Rapidly Progressive and Extensive Anterior-Wall ST-Segment Elevation Myocardial Infarction
Authors: Okada Kozo , Hibi Kiyoshi , Kikuchi Shinnosuke , Kirigaya Hidekuni , Hanajima Yohei , Sato Ryosuke , Nakahashi Hidefumi , Minamimoto Yugo , Matsuzawa Yasushi , Maejima Nobuhiko , Iwahashi Noriaki , Kosuge Masami , Ebina Toshiaki , Tamura Kouichi , Kimura Kazuo 
Published: November 2022

Background:
Rapidly progressive, extensive myocardial injury/infarction (RPEMI) beyond the concept of wave-front phenomenon can be observed even when achieving timely reperfusion; however, the pathogenesis of RPEMI remains unknown. This retrospective study investigated clinical and lesion characteristics of RPEMI, focusing on culprit-lesion morphology (CLM).

Methods:
Among patients with extensive anterior-wall ST-segment elevation myocardial infarction due to proximal left anterior descending artery lesions who had reperfusion within 3 hours of symptom onset, 60 patients undergoing both intravascular ultrasound and cardiac magnetic resonance imaging were enrolled. Myocardial injury/infarction before reperfusion therapy was assessed by QRS scores at hospitalization electrocardiogram, and the extent of myocardial injury/infarction was evaluated by cardiac magnetic resonance imaging, which measured area at risk, infarct size, myocardial salvage index, microvascular obstruction, and left ventricular ejection fraction. RPEMI was defined as lower left ventricular ejection fraction (less median value) with microvascular obstruction.

Results:

Despite comparable onset-to-door and onset-to-reperfusion times and area at risk, patients with RPEMI showed higher QRS scores at hospitalization (5 [4.3–6] versus 3 [2–4],
P
<0.001) and infarct size (26.5±9.1 versus 20.4±10.5%,
P
=0.04), and a tendency toward lower myocardial salvage index (0.27±0.14 versus 0.36±0.20,
P
=0.10) compared with those without. Patients with versus without RPEMI more frequently observed specific CLM on intravascular ultrasound, characterized by the combination of vulnerable plaques, plaque ruptures, and/or large thrombi. When stratified by CLM-score composed of these 3 criteria, higher CLM-scores were or tended to be associated with higher QRS scores and incidence of RPEMI. In multivariate analyses including no-reflow phenomenon and final coronary-flow deterioration, increased CLM-score (≥2) was independently associated with high QRS scores and RPEMI (odd ratio 11.25 [95% CI, 2.43–52.00];
P
=0.002).

Conclusions:
Vulnerable CLM was a consistent determinant of advanced myocardial injury/infarction both before and after reperfusion therapy and may play a pivotal role in the development of RPEMI.
Optimal Echocardiographic Parameters to Improve the Diagnostic Yield of Tc-99m-Bone Avid Tracer Cardiac Scintigraphy for Transthyretin Cardiac Amyloidosis
Authors: Cuddy Sarah AM , Datar Yesh , Ovsak Gavin , Saith Sunil , Murphy Sean P. , Bay Camden P. , Haddad Mia , Lilleness Brian , Muralidhar Varsha , Pipilas Alexandra , Vuong Jacqueline , Guardino Eric , Maurer Mathew S. , Ruberg Frederick L. , Falk Rodney H. , Dorbala Sharmila 
Published: November 2022

Background:
Echocardiographic deformation-based ratios and novel multi-parametric scores have been suggested to discriminate transthyretin cardiac amyloidosis (ATTR-CM) from other causes of increased left ventricular wall thickness among patients referred for ATTR-CM evaluation. Their relative predictive accuracy has not been well studied. We sought to (1) identify echocardiographic parameters predictive of ATTR-CM and (2) compare the diagnostic accuracy of these parameters in patients with suspected ATTR-CM referred for technetium-99m-pyrophosphate scintigraphy.

Methods:
Echocardiograms from 598 patients referred to 3 major amyloidosis centers for technetium-99m-pyrophosphate to detect ATTR-CM were analyzed, including longitudinal strain (LS) analysis. Deformation ratios (septal apex to base ratio, relative apical sparing, ejection fraction to global LS), a multi-center European increased wall thickness score, and Mayo Clinic derived ATTR score (transthyretin cardiac amyloidosis score) were calculated. A logistic regression model was used to identify the parameters that best associated with a diagnosis of ATTR-CM. Comparison of the diagnostic capacity of the parameters was performed by receiver operating characteristic curves and the area under the curve (AUC).

Results:

Over half of the subjects (54.2%) were diagnosed with ATTR-CM (78% were men, median age of 76 years). Age, inferolateral wall thickness, and basal LS were the strongest predictors of ATTR-CM, AUC of 0.87 (95% CI: 0.83, 0.90), superior to the increased wall thickness score AUC of 0.78 (95% CI: 0.73, 0.83;
P
=0.004). An inferolateral wall thickness of ≥14 mm (AUC: 0.73) was as accurate as the published cut-offs for transthyretin cardiac amyloidosis score and septal apex to base (AUC: 0.72 and 0.69,
P
=0.8 and
P
=0.1, respectively), and was superior to ejection fraction to global LS and relative apical sparing (AUC: 0.64 and 0.53,
P
<0.001, respectively). A cut-off of ≥−8% for average basal LS (AUC: 0.76, CI: 0.72–0.79) had a similar area under the curve to transthyretin cardiac amyloidosis score (TCAS) (
P
=0.2); outperforming the other indices (
P
<0.01).

Conclusion:
Inferolateral wall thickness and average basal LS performed as well as or better than more complex echo ratios and multiparametric scores to predict ATTR-CM.
Impact of Intravascular Ultrasound–Derived Lesion-Specific Virtual Fractional Flow Reserve Predicts 3-Year Outcomes of Untreated Nonculprit Lesions: The PROSPECT Study
Authors: Seike Fumiyasu , Mintz Gary S. , Matsumura Mitsuaki , Ali Ziad A. , Liu Mengdan , Jeremias Allen , Ben-Yehuda Ori , De Bruyne Bernard , Serruys Patrick W. , Yasuda Kazunori , Stone Gregg W. , Maehara Akiko 
Published: November 2022

Background:
Hemodynamic assessment of untreated nonculprit lesions was not studied in the PROSPECT study (Providing Regional Observations to Study Predictors of Events in the Coronary Tree). We developed a virtual intravascular ultrasound–derived lesion-specific fractional flow reserve (lesion-specific IVUS-FFR) algorithm to assess individual lesion-level FFR. We sought to investigate the relation between lesion-specific IVUS-FFR and major adverse cardiovascular events (MACE) arising from untreated nonculprit lesions in the PROSPECT study.

Methods:
In PROSPECT, 697 patients with acute coronary syndromes underwent 3-vessel grayscale and virtual histology–IVUS to correlate untreated nonculprit plaque morphology with 3-year nonculprit related MACE (composite of cardiac death, cardiac arrest, myocardial infarction, or rehospitalization due to unstable or progressive angina). Lesion-specific IVUS-FFR was calculated from volumetric IVUS lumen area measurements at 0.4 mm intervals by applying a mathematical circulation model using basic fluid dynamics equations.

Results:

Lesion-specific IVUS-FFR was analyzable in 3227 nonculprit lesions in 660 patients among whom 54 nonculprit MACE events (3 myocardial infarctions) occurred at median 3.4-year follow-up. By receiver-operating characteristic analysis, the best cutoff value of lesion-specific IVUS-FFR to predict nonculprit MACE was ≤0.95. After adjusting for patient and lesion characteristics, lesion-specific IVUS-FFR (hazard ratio, 4.83 [95% CI, 2.20–10.61];
P
<0.001) was an independent predictor of 3-year nonculprit MACE, in addition to minimum lumen area≤4.0 mm
2
, plaque burden ≥70%, and virtual histology thin-cap fibroatheroma.

Conclusions:
Minor reductions in lesion-specific IVUS-FFR were independently associated with future nonculprit MACE arising from untreated angiographically mild stenoses along with previously established high-risk lesion morphological characteristics.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT00180466.
Hemispheric Asymmetries of Individual Differences in Functional Connectivity
Authors: Perez Diana C. , Dworetsky Ally , Braga Rodrigo M. , Beeman Mark , Gratton Caterina 
Published: November 2022

Abstract
Resting-state fMRI studies have revealed that individuals exhibit stable, functionally meaningful divergences in large-scale network organization. The locations with strongest deviations (called network “variants”) have a characteristic spatial distribution, with qualitative evidence from prior reports suggesting that this distribution differs across hemispheres. Hemispheric asymmetries can inform us on constraints guiding the development of these idiosyncratic regions. Here, we used data from the Human Connectome Project to systematically investigate hemispheric differences in network variants. Variants were significantly larger in the right hemisphere, particularly along the frontal operculum and medial frontal cortex. Variants in the left hemisphere appeared most commonly around the TPJ. We investigated how variant asymmetries vary by functional network and how they compare with typical network distributions. For some networks, variants seemingly increase group-average network asymmetries (e.g., the group-average language network is slightly bigger in the left hemisphere and variants also appeared more frequently in that hemisphere). For other networks, variants counter the group-average network asymmetries (e.g., the default mode network is slightly bigger in the left hemisphere, but variants were more frequent in the right hemisphere). Intriguingly, left- and right-handers differed in their network variant asymmetries for the cingulo-opercular and frontoparietal networks, suggesting that variant asymmetries are connected to lateralized traits. These findings demonstrate that idiosyncratic aspects of brain organization differ systematically across the hemispheres. We discuss how these asymmetries in brain organization may inform us on developmental constraints of network variants and how they may relate to functions differentially linked to the two hemispheres.
The Qumran Opisthograph 4Q509/4Q496/4Q506 as an Intentional Collection of Prayers
Authors: Aksu Ayhan 
Published: November 2022

Abstract
4Q509/4Q496/4Q506 is the only opisthograph from Qumran with extant evidence for three different compositions: the recto preserves a copy of Festival Prayers (4Q509), and the verso contains copies of the War Scroll (4Q496) and Words of the Luminaries (4Q506). This article investigates the circumstances under which these texts were written down together, and explores a potential performative setting for this manuscript. Palaeographic and codicological examination indicates that the manuscript preserves extracts of these three compositions and shares similar scribal features on both the recto and verso. Literary and form-critical analysis suggests a performative context for Festival Prayers, Words of the Luminaries, and the War Scroll. Based on these considerations, I argue that different scribes wrote 4Q509, 4Q496, and 4Q506 intentionally together in order to create a liturgical collection on a single manuscript—highlighting the scribe as a collectionneur that purposely selected passages from different texts that were of importance.
Performance in Ancient and Medieval Judaism
Authors: Khan Geoffrey , Najman Hindy 
Published: November 2022

Abstract
This article explores the performance of Jewish sacred textual traditions. Performance, as we define it, is both textual and oral and works dynamically between the two. In the Second Temple period, we show the variety of performance which embodies the vitality of the texts. Performance is a feature of scribal practice and liturgy (e.g., Hodayot). It draws on existing text to create something new (e.g., Apostrophe to Zion). From the Second Temple period into the Middle Ages, we see continued pluriformity in the oral performance of the written text of the Hebrew Bible. Creativity is evident across oral and material representation. The texts discussed throughout this article remained dynamic and diverse. The focus and scope of this article also prepares for many of the ideas picked up by the essays which follow in this volume.
Dots, Versification and Grammar
Authors: Lundberg Johan M.V. 
Published: November 2022

Abstract
The Syriac gospel of Matthew is divided into sentences by means of pausal accent dots, both single clause sentences and complex sentences. This article explores the relationship between these pausal accent dots and verse division, comparing the Syriac dotting system with Greek punctuation marks and Hebrew accents. All three traditions divide the text into larger and smaller sections. In the Hebrew Bible the smaller sections are often classified as verses that are further subdivided through cantillation marks, typically called accents. This article explains why the Syriac dots, also called accents, have a fundamentally different function than the Hebrew accents. It also explores the similarities between the Syriac dots and the Greek punctuation marks. The conclusion is that the “verse” is not a concept that can easily be applied to Syriac Bible manuscripts. Instead, the Syriac dots indicate different types of boundary tones, pauses associated with a specific pitch contour.
Variations on a Theme by Muḥammad
Authors: Nasser Shady Hekmat 
Published: November 2022

Abstract
This essay explores the tense relationship between the oral and written transmissions in the history of the Qurʾān. While Muslim scholars consider “orality” to be the cornerstone in the process of transmitting their holy text, I argue that writing, in its various forms, was a crucial element in transmitting and validating the Qurʾān. Orality was also an important component in this process of transmission but it also played a theological role in establishing the superiority of the Qurʾān over the Bible. Indeed, the written transmission of the Qurʾān might have been more authoritative than its oral counterpart, which was/is mainly used as an argumentative device to establish the integrity of the text rather than to establish the text itself.
The Physical Processes Dominating the Impact of the Summer North Atlantic Oscillation on the Eastern Tibetan Plateau Summer Rainfall
Authors: Hu Shuai , Zhou Tianjun , Wu Bo 
Published: November 2022

Abstract
The summer North Atlantic Oscillation (SNAO), an important climate signal in regulating the interannual variability of Tibetan Plateau (TP) summer rainfall, is closely related to a meridional precipitation dipole pattern between the southeastern and northeastern TP. In this study, based on diagnoses of observations and multiple realizations of the CESM2 historical simulation, we find that there are fundamental differences between the formation processes dominating the SNAO-related summer rainfall anomaly in the southeastern and northeastern TP. An atmospheric moisture budget analysis reveals that the anomalous vertical (horizontal) moisture advection makes the largest contribution to the southeastern (northeastern) TP summer rainfall anomaly. During the negative phase of SNAO, the increased precipitation in the southeastern TP is related to the anomalous ascending flows, which are driven by two processes according to the moist static energy budget. The first is the southward shift of the subtropical westerly jet stream, which produces positive anomalous zonal advection of the climatological moist enthalpy in the upper-middle troposphere over the southeastern TP. The second is related to the enhanced transport of anomalous warm moist air to the south of TP, which produces positive anomalous meridional advection of anomalous moist enthalpy into the lower troposphere over the southeastern TP under the control of climatological monsoonal meridional circulations. This positive moist enthalpy advection enhances the atmospheric moist static energy and facilitate enhanced local convection. For the northeastern TP, the decreased precipitation is dominated by negative anomalous horizontal moisture advections due to the SNAO-induced equivalent-barotropic anomalous cyclone near the eastern edge of the TP.
SNOT-22 Quality of Life Scores Improve After Endoscopic Endonasal Repair of Spontaneous Cerebrospinal Fluid Rhinorrhea
Authors: Liu Matthew Y. , Woodworth Bradford A. , Kanaan Alissa , Jang David W. , Yao William C. , Radabaugh Jeffrey Paul , Gardner James Reed , Goros Martin , Grayson Jessica W. , Wang Zhu , Chen Philip G. 
Published: November 2022

Objectives: Patients with spontaneous cerebrospinal fluid (CSF) rhinorrhea can experience significant sinonasal symptom burden, leading to poor quality of life (QOL). The objective of this study was to investigate sinonasal outcome test-22 (SNOT-22) scores in patients undergoing endoscopic endonasal surgery for spontaneous CSF rhinorrhea and compare them to patients undergoing endoscopic sinus surgery (ESS) for chronic rhinosinusitis without nasal polyps (CRSsNP). Methods: A multi-institutional retrospective review of patients with spontaneous CSF rhinorrhea and CRSsNP was performed. Pre-surgery and post-surgery SNOT-22 scores and domains were compared within each group. Improvements in SNOT-22 scores after surgery were compared between the groups. Results: Ninety-one patients were in the CSF rhinorrhea group and 105 patients were in the CRSsNP group. Within each group, surgery significantly improved total SNOT-22 scores, domain scores, and most of the individual symptoms. Comparing the 2 groups revealed similar improvements in total SNOT-22 scores ( P = .244). The CSF rhinorrhea group improved more in runny nose ( P < .001), postnasal discharge ( P < .001), wake up at night ( P = .024), and embarrassed ( P = .002). The CRSsNP group improved more in sneezing ( P = .027), nasal blockage ( P < .001), decreased sense of smell/taste ( P = .011), thick nasal discharge ( P < .001), facial pain/pressure ( P = .008), and the ear/facial domain ( P = .010). Conclusions: Patients with spontaneous CSF rhinorrhea experience significant symptom burden. Those who undergo CSF leak repair should experience significant improvement in QOL similar to patients who undergo ESS for CRSsNP as measured by SNOT-22.
Influence of micro crystalline cellulose on EPDM-based automotive sealing profile
Authors: Poyraz Bayram , Güner Yusuf , Yardım Tayfun , Yamanoğlu Rıdvan , Tozluoğlu Ayhan , Durmuş Sefa , Şen Murat 
Published: November 2022

This study examined the effects of microcrystalline cellulose (MCC) used in EPDM elastomer composites in replace of EPDM. For that purpose, the MCC was added in amounts of 1.75; 3.5, and 5.25 phr to investigate the chemical, thermal, rheological, mechanical, morphological, and dielectric properties of EPDM elastomers. At the end of the study, the MCC enabled increased tensile strength, and elongation while causing lower thermal stability and Mooney scorch. The MCC also facilitated the vulcanization process by providing faster production while mixing homogeneously in the matrix. In addition, it decreased dielectric lossyness as well as increased the electric charge storage capacity. However, E-Cel2, containing 3, 5 phr MCC, was found to be more suitable for high-K applications, whereas E-Cel3 was more suitable for low-loss applications. In conclusion, MCC can be also recommended to automotive industries to provide more biocompatible and enhanced properties as a substitute for EPDM.
Rural Education and the State in Mexico: The Legacy of Elena Torres Cuellar
Authors: Calderón Marco 
Published: November 2022

Background/Context: This article is part of a broader investigation of the sociocultural history of rural education in Mexico that focuses on federally financed “social experiments,” the main purpose of which was to find “effective” methods to educate and “civilize” the rural population, especially Indigenous people. Purpose/Objective: Although the contributions of Elena Torres Cuellar, a graduate of Columbia University’s Teachers College, to rural education in Mexico were very important, comparatively little is known about her life and legacy. Research Design & Data Collection: This historical essay uses archival and primary sources to recover fundamental aspects of the legacy of Elena Torres Cuellar in the history of Mexican rural education in the context of the construction of the postrevolutionary state and political system. The article approaches this legacy through analysis of Torres’s career trajectory, emphasizing her work for the Secretariat of Public Education. Conclusions: Elena Torres Cuellar had a big influence on the organization of Mexico’s Cultural Missions and other projects in rural education. Torres Cuellar’s studies on rural education at Teachers College under the mentorship of Mabel Carney in 1925 and 1926 were fundamental to Torres’s life and work. The importance of women educators and social workers as well as their empowerment are central themes in her life and career.
Implementation of enhanced recovery in cardiac surgery: An experimental study with the control group
Authors: Hendy Ayman , DiQuinzo Claudio , O'Reilly Mark , Hendy Abdelaziz , Vician Michael , Theriault Chris , Chedrawy Edgar , Hirsch Gregory , Aliter Hashem 
Published: November 2022

Introduction The Enhanced Recovery After Cardiac Surgery protocol is the most recent addition to cardiac treatment. In this paper, we aimed to test the safety and viability of this protocol in our hospital to improve our standard of care. Methods This study was conducted as an experimental study with a historical control at the Maritime Heart Center, Halifax, Nova Scotia, Canada. In order to quantify the success of this protocol, we measured the postoperative Length of Hospital Stay and three intensive care unit variables: time to extubation, time to ambulation, and opioid consumption. In the study, 100 patients were in the Enhanced Recovery After Cardiac Surgery group, and 103 patients were used as historic controls-selected by strenuous chart review and selection criteria. Results The primary outcome (Length of Hospital Stay) was reduced from a mean of 8.88 ± 3.50 days in the control group to a mean of 5.13 ± 1.34 days in the Enhanced Recovery After Cardiac Surgery group ( p < 0.001). Likewise, we observed a significant reduction in intensive care unit variables: time to extubation was reduced from 10.54 ± 7.83 h in the control group to 6.69 ± 1.63 in the Enhanced Recovery After Cardiac Surgery group ( p < 0.01), and time to ambulation was reduced from 36.27 ± 35.21 h in the control group to 9.78 ± 2.03 in the Enhanced Recovery After Cardiac Surgery group ( p < 0.01) and opioid consumption was reduced from 50.58 ± 11.93 milligram morphine equivalent in the control group to 11.58 ± 4.43 milligram morphine equivalent in the Enhanced Recovery After Cardiac Surgery group ( p < 0.01). Conclusion Enhanced Recovery After Cardiac Surgery protocols were seamlessly integrated into selected cardiac surgical patients, contingent on a high level of interprofessional communication and collaboration.