bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Study of the Effect of Occupational Stress on Resilience: Mediating Role of Occupational Engagement (A Case Study: Nurses of Al-zahra Hospital in Isfahan)
Authors: Sabookro Mehdi , Sheyda Ali , Porhosein Mahshid 
Published: June 2022

Introduction: Considering the high mental pressures on nurses at work, identifying the effective resilience factors is deemed necessary. Therefore, this study aims to investigate the mediating role of occupational engagement in the relationship between occupational stress and resilience among the nurses of Al-zahra Hospital of Isfahan.
Methods: The present study was a descriptive survey-correlational study. The population of this study included 1700 nurses from Al-zahra hospital in Isfahan city. Based on Cochran’s formula and by convenience sampling method, 200 people (60 men and 140 women) were chosen. Occupational stress questionnaires of HSE, resilience, and occupational engagement were performed on the sample. The collected data were analyzed using SPSS and AMOS software using structural equation modeling.
Results: The results showed that occupational stress had a negative and significant effect (P <0.001) on the vibration with the mediating role of occupational engagement. Also, occupational stress had a negative and significant (P <0.001) negative effect on occupation and there was a significant and positive effect (P <0.001) on resilience.
Conclusion: The results indicate that occupational stress affects the resilience, but if the nurses are engaged in their jobs, this effect will reduce and the construct of engagement will act as a mediating variable.
The Effectiveness of Integrated Monotheistic Therapy on the Mental Health of Mothers of Children with Special Needs (Physical Illnesses) during the COVID-19 Pandemic
Authors: Shayegh Mohammad Ali , Sajjadi FaridehSadat , Dashtabadi Masomeh , Yavari Fatemeh 
Published: June 2022

Introduction: Parents’ challenges in care of the children with special health care needs expose them to a high risk of developing psychological symptoms, such as increased anxiety and worry. This study aimed to investigate the effect of integrated monotheistic therapy (MIT) on the mental health of mothers of children with special needs (physical illnesses) during the COVID-19 pandemic.
Methods: From this statistical population, using convenience sampling method, 60 mothers with severely physically ill children were selected who after testing as a pre-test and 30 people were randomly divided into experimental and control groups. A mental health questionnaire was used. Then, the treatment sessions were held in 8 sessions of 120 minutes by observing the health protocol for the subjects in the experimental group. Then, the data were collected and analyzed by SPSS statistical software using analysis of covariance.
Results: The results show that after controlling the pre-test scores, the effect of the group on the post-test scores of mental health was significant (p <0.001, F = 3.31). In other words, there was a significant difference between the subjects of the experimental and control groups in the mean scores of mental health in the post-test stage.
Conclusion: It can be concluded that MIT treatment has an effect on the mental health of mothers of children with special needs (physical illnesses) during the COVID-19 pandemic as well as special conditions where stress and inflammation are on this sensitive and vulnerable group.
The Effect of Real Estate Registration Documents on the Mental Health of Society
Authors: Karimi Ali , Karimi Abas 
Published: June 2022

Undoubtedly, the mental health of the society is effective in the progress and development of the country and an important part of this mental health is due to the trust and confidence of economic activists in their investment. Considering that the realm of important investments is land and immovable property, and if the ownership of these lands is built on a shaky foundation, the whole property and economy system will be insecure. In this study, considering the data collected through library study and collection of documents, it was proved that the developments in the field of judiciary and legislation in recent decades have contributed to this insecurity and posed a serious threat to the mental health of economic actors. In order to compensate for this situation and restore this mental health, it was proposed in the process provided by the Law on Registration of Documents and Property to establish the right of ownership, through the amendment of the law, the validity of two important and basic ownership documents should be restored, including the ownership certificate and the ownership document. The best method of the legislator's intervention was to amend and complete Article 22 of the Law on Registration of Documents and Property.
Evaluating the Causal Relationship in Treatment-Induced Injuries
Authors: Karimzadeh Shurok Mohammad Hossein , Haji Dehabadi Ahmad , Barzegar Abdolreza 
Published: June 2022

Mistakes in the treatment of patients are an inseparable part of medical field. However, diagnosing whether there is a causal effect between the physicians fault and the injury received by the patient is the complexity of cases related to medical offense. Islamic Penal Code 1392 has made basic changes not only by creating treatment liability and replacing physician fault theory instead of pure liability of the physician theory, but it also , concerning that the relation between causation and citation should hold distance from materialistic and philosophical controversies and thus heading a new approach by believing that the science of Law is formed on the basis of customary relations, has tried to use custom and the degree of reprehensibility of the criminal act and distance itself from philosophical controversies and bring the rule of causation closer to justice and fairness. The legislator of 1392 has made fundamental developments in this field such as accepting relative liability, the possibility of simultaneously invoking the crime to the director and the cause and the element of intention in relation to causation and accepting the omission of an act as the cause of a crime. In this study, with focus on the causal relation in the treatment liability and by investigating whether an issues such as the underlying disease, the physician's fault and also some omissions by the physician can be the causes of crime or not? We will evaluate these changes and the probable defects in this law.
The Evaluation of Relationship Between Monocyte/High-Density Lipoprotein Ratio (MHR) and COVID-19
Authors: COŞKUN Belgin , AYHAN Müge , SARICAOĞLU Elif Mukime , GÜNER Rahmet , AKINCI Esragül , BUZGAN Turan , KAYAASLAN Bircan , AYPAK Adalet , TEZER TEKÇE Ayşe Yasemin , HASANOĞLU İmran , KAYA KALEM Ayşe , ESER Fatma , AYBAR BİLİR Yeşim , ÖZDEMİR Burcu 
Published: June 2022

Objective: Early diagnosis is important for severe diseases in COVID-19. Monocyte/high dansity lipoprotein ratio (MHR) is a new prognostic marker indicating inflammation. We aimed to investigate the relationship between MHR and diseases severity in COVID-19.
Materials and Methods: Patients with laboratory confirmed COVID-19, were retrospectively analyzed. Clinical symptoms, signs and laboratory data on the first day of hospitalization were obtained from medical records of hospital. The clinical data of 301 patients were included in study. Cases were diagnosed on the basis of interim guidance of World Health Organization (WHO). Patients were classified into two groups as non-severe COVID-19 and severe COVID-19. MHR were calculated with laboratory data on the first day of hospitalization. The relationship between MHR level and COVID-19 severity was evaluated. Statistical analysis of the data was performed by using SPSS 25 (SPSS Inc., Chicago, IL, USA) package program. Statistical significance level was accepted as p
Special Issue on Creative Robot Contest for Decommissioning
Authors: Yamashita Osamu , Suzuki Shigekazu , Doi Tomoharu 
Published: June 2022

The decommissioning of the Fukushima Daiichi Nuclear Power Plant, the plant affected by the Great East Japan Earthquake, will continue for a long time to come, but few young people are willing to take on the challenge because they tend to have the impression that decommissioning work is a post-accident cleanup. However, decommissioning is the most important issue for Fukushima and is of global importance.
Therefore, the National Institute of Technology, Fukushima College (Fukushima KOSEN), which is located closest to the Fukushima Daiichi Nuclear Power Plant, established a council of cooperation and started the Creative Robot Contest for Decommissioning in cooperation with other National Institute of Technologies (KOSEN) to increase the awareness and interest in decommissioning among the young.
The robot contest, themed on issues related to the decommissioning of the Fukushima Daiichi Nuclear Power Plant, has been held annually since 2016 for students of KOSEN across Japan, and the 7th Creative Robot Contest for Decommissioning is scheduled to be held in December 2022.
Although the ideas and robots developed by KOSEN students from all over Japan to solve the problems involved in the decommissioning will not directly contribute to future decommissioning work, the ideas and technologies learned can be used in other fields, and the participating students are expected to be active in a wide range of fields as well.
This special issue contains review papers of the Creative Robot Contest for Decommissioning, development reports, and research papers on the robots developed. A total of eight papers are included: two review papers, two research papers, and four development reports on decommissioning robots designed by students.
At the same time, we hope that young people in Japan and abroad will also become interested in the robots introduced in this special issue, and that the decommissioning work of Fukushima Daiichi Nuclear Power Plant will proceed safely and securely by combining the wisdom of the whole world.
Efficacy and safety analyses of epidermal growth factor receptor tyrosine kinase inhibitors combined with chemotherapy in the treatment of advanced non–small-cell lung cancer with an EGFR/TP53 co-mutation
Authors: Shang Kai , Huang Hongxiang , Xu Yongkang , Liu Yangyang , Lu Zhihui , Chen Li 
Published: June 2022

Abstract
Purpose: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) combined with cytotoxic chemotherapy are highly effective in the treatment of advanced non–small-cell lung cancer (NSCLC) with EGFR mutations. The purpose of this study is to evaluate the efficacy and safety of this combination in advanced NSCLC patients with an EGFR/TP53 co-mutation. Materials and Methods: Ninety-five advanced NSCLC patients with an EGFR/TP53 co-mutation were enrolled in this study. Treatments with either EGFR-TKI monotherapy (T group, n = 61) or EGFR-TKI combined with chemotherapy (TC group, n = 34) were evaluated in relation to objective response rate (ORR), disease control rate (DCR), median time to progression (TTP), and median overall survival (OS).Results: There were no statistically significant differences in DCR between the treatment groups. The ORR was significantly improved in the TC group versus the T group (55.9% vs. 34.4%, P = 0.042). A higher median TTP was noted in TC group compared with T group (16.1 vs. 11.1 months, P = 0.002). Patients without brain metastases in TC group had a longer median OS than in T group (48.4 vs. 28.8 months, P = 0.003). However, there was a non-significant trend towards longer OS in TC group in the entire cohort (36.9 vs. 28.2 months, P = 0.078). Cox multivariate regression analysis showed that clinical stage, brain metastases, EGFR21 L858R mutation, and T790M status at first progression were independent risk factors for OS. However, the incidence of grade 3 or higher adverse events were higher in the TC group than in the T group (32.4% vs. 13.1%, P=0.025).Conclusion: Our study indicates that EGFR-TKIs combined with chemotherapy could significantly improve the ORR and TTP of advanced NSCLC patients with an EGFR/TP53 co-mutation. Combination therapy may be a promising treatment for advanced NSCLC patients with an EGFR/TP53 co-mutation without brain metastases.
Buckling variation effects on optical and electronic properties of GeP2S nanostructure: A first-principles calculation
Authors: Alborznia Hamidreza , Amirian Shirin , Nazirzadeh Mehdi 
Published: June 2022

Abstract
In this study, by using the first-principles calculations based on density functional theory (DFT), the electronic aspects of GeP2S monolayer under the effect of buckling variation parameter (µ = 0, 2, 4, 6) are theoretically investigated by the PBE-GGA approximation method, and the obtained results have been compared with previous similar structures. We presented the imaginary part of the dielectric function and absorption spectra for in-plane and out-of-plane polarization of GeP2S monolayer by PBE, HSE06, and TD-HSE06 methods. Also, optical aspects for this 2D nanostructure are presented in out-of-plane polarization under buckling variation conditions up to µ = 6. It was shown that particularly for the range of visible light spectrum its optical behaviors match with its electronic ones. Consequently, the obtained results suggest GeP2S as a suitable material for designing optoelectronic devices.
Group psychoeducation for persons with bipolar disorder in Rwanda: A study protocol for a randomized controlled trial
Authors: MUSONI-RWILILIZA Emmanuel RWILILIZA , Arnbjerg Caroline Juhl , Murekatete Chantal , Carlsson Jessica , Kallestrup Per , Gishoma Darius 
Published: June 2022

Abstract
Background: The efficacy of psychoeducation as an add-on treatment to pharmacotherapy is well documented in treating symptoms and in relapse prevention for persons with bipolar disorder in western countries. Yet, no studies on psychosocial interventions for persons with bipolar disorder have been conducted in a low-income country in Africa.Aim: To develop a bipolar group psychoeducation program contextualized to the Rwandese setting, and determine its effect on symptom severity, medical adherence, and internalized stigma.Methods: A culturally adapted guide manual will be developed by local mental health professionals, including nurses, psychologists, and medical doctors. In-depth interviews with participants will be held prior to and after the intervention to address the cultural aspect of living with bipolar disease and the impact of the program. A two-armed randomized controlled trial will be set up at the tertiary mental health hospitals in Rwanda, with an intervention- and a waiting-list-arm. A sample size of at least 50 in each arm will be required. The study’s primary outcome measure will be the difference in relapse rate measured on the Young Mania Rating Scale and Hamilton Depression Scale-17. Differences in mean change on scales for medical adherence and internalized-stigma will be secondary outcomes. Data will be analyzed according to the intention-to-treat principle. Participants will be assessed at baseline, then at the end of the intervention period, and three months and 12 months post-intervention. Discussion: This study will be one of the first intervention trials on bipolar disorder in a low-income country. If proven successful in reducing morbidity and increasing the quality of life in persons with bipolar disorder, it is anticipated that the psychoeducation program can be implemented at the district and community level and act as inspiration for other low-resource settings. Trial registration: ClinicalTrials.gov, Identifier: NCT04671225, Registered retrospectively in November 2020.
Follow up study of infants recruited to the randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants – Study protocol for the AZTEC-FU Study
Authors: Kotecha Sarah J , Course Christopher W , Jones Kathryn E , Watkins W John , Berrington Janet , Gillespie David , kotecha Sailesh 
Published: June 2022

Abstract
Background: Preterm birth, especially at less than 30 weeks’ gestation, is significantly associated with respiratory, neurodevelopmental and growth abnormalities. The AZTEC study has recruited 799 infants born at <30 weeks’ gestation to determine if a ten-day intravenous treatment with azithromycin improves survival without development of chronic lung disease of prematurity (CLD) at 36 weeks’ post menstrual age (PMA) when compared to placebo. The follow up studies will compare respiratory, neurodevelopmental and growth outcomes up to 2 years of corrected age between infants who received azithromycin and those who received placebo in the early neonatal period.Methods: Survivors at 36 weeks’ PMA from the main AZTEC study with parental consent will continue to be followed up to discharge from the neonatal unit and to two years of corrected age. Length of stay, rates of home oxygen, length of supplemental oxygen requirement, hospital admissions, drug usage, respiratory illness, neurodevelopmental disability and death rates will be reported. Data is being collected via parentally completed respiratory and neurodevelopmental questionnaires at one and two years of corrected age respectively and additional information is being obtained from various sources including hospital discharge and clinical letters from general practitioners and hospitals as well as from national databases including the National Database Analyses Unit and NHS Digital. Discussion: The AZTEC-FU will assess mortality and important neonatal morbidities including respiratory, neurodevelopmental and growth outcomes. Important safety data will also be collected, including the incidence of potential consequences of early macrolide use, primarily pyloric stenosis. This study may have implications on future neonatal care.Trial registration: The study was retrospectively registered on ISRCTN (ISRCTN47442783).
Aetiology and clinical characteristics of psoas abscesses in China, 2011-2021: A retrospective study
Authors: Xu Chengan , zhou Zhewen , Wang Shouhao , Wu Wenhao , Hui Tianchen , Ren Wenya , Yang Xingdi , Chen Hanzhu , Zheng Wei , Yin Qiaoqiao , Pan Hongying 
Published: June 2022

Abstract
Psoas abscess (PA) is an uncommon disease that has been increasingly reported in recent years. We reviewed patients with PA and analysed their clinical characteristics to improve the understanding of this rare disorder. The study retrospectively reviewed the clinical presentations, microbiology, and outcomes of patients with PA between 2011 and 2021 in Zhejiang Provincial People’s Hospital in China. There were 35 cases out of 23057427 hospitalised adult patients; the mean age was 60 years, and 65.7% of the patients were male. Primary symptoms were typically nonspecific. In all, 17 abscesses were considered secondary, and the most common aetiology was infective spondylitis. The most common causative organism for primary PA was Staphylococcus aureus, followed by Escherichia coli, while for secondary abscesses, there were multiple bacterial species. The overall in-hospital mortality rate was 6%. Secondary PA patients had longer hospital stays (mean, 23 vs. 28 days). PAs, as a serious infectious condition, usually present with nonspecific symptoms and laboratory test results, making early diagnosis difficult. The aetiological profiles differed from those reported in our study. Initial clinical status and subsequent imaging studies can lead to favourable outcomes.
EIF4A inhibition targets bioenergetic homeostasis in AML and synergizes with cytarabine and venetoclax
Authors: Fooks Katie , Galicia-Vazquez Gabriela , Schcolnik-Cabrera Alejandro , Gife Victor , Nouhi Zaynab , Poon William WL , Luo Vincent , Aloyz Raquel , Orthwein Alexandre , Hulea Laura , Mercier François E 
Published: June 2022

Abstract
Background
Acute myeloid leukemia (AML) is an aggressive hematological cancer resulting from uncontrolled proliferation of differentiation-blocked myeloid cells. Seventy percent of AML patients are currently not cured with available treatments, highlighting the need of novel therapeutic strategies. A promising target in AML is the mammalian target of rapamycin complex 1 (mTORC1). Clinical inhibition of mTORC1 is limited by its reactivation through compensatory and regulatory feedback loops. Here, we developed a strategy to curtail these drawbacks through inhibition of an mTORC1 target, the eukaryotic initiation factor 4A (eIF4A).
Methods
We tested the anti-leukemic effect of a potent and specific eIF4A inhibitor (eIF4Ai), CR-1-31-B, in combination with cytosine arabinoside (araC) or the BCL2 inhibitor venetoclax. We utilized the MOLM-14 human AML cell line to model chemoresistant disease both in vitro and in vivo. In eIF4Ai-treated cells, we assessed for changes in survival and apoptosis, de novo protein synthesis, targeted intracellular metabolite content, bioenergetic profile, mitochondrial reactive oxygen species (mtROS) and mitochondrial membrane potential (MMP).
Results
eIF4i exhibits anti-leukemia activity in vivo while sparing non-malignant myeloid cells. In vitro, eIF4Ai synergizes with two therapeutic agents in AML, araC and venetoclax. eIF4Ai reduces mitochondrial membrane potential (MMP), the rate of ATP synthesis from mitochondrial respiration and glycolysis, and the expression of the antiapoptotic factors BCL2 and MCL1. Concomitantly, eIF4Ai decreases intracellular levels of specific metabolic intermediates of the tricarboxylic acid cycle (TCA cycle) and glucose metabolism, while enhancing mtROS. In vitro redox stress contributes to eIF4Ai cytotoxicity.
Conclusions
We discovered that AML cells rely on eIF4A-dependent cap translation for survival in vitro and in vivo. Our work indicates that eIF4A drives an intrinsic metabolic program sustaining bioenergetic and redox homeostasis. Furthermore, our work suggests that eIF4A-dependent cap translation contributes to adaptive processes involved in resistance to relevant therapeutic agents in AML.