bluuebunny/crossref_metadata_2025_split huggingface dataset:
Density and porosity optimization of graphene monoliths with high mass‐loading for high‐volumetric‐capacitance electrodes
Authors: Wang Dongliang , Sheng Lizhi , Jiang Meihui , Jin Xin , Lin Xinru , Lee Sang‐Young , Shi Junyou , Chen Wenshuai 
Published: August 2022

AbstractImproving the volumetric capacitance of graphene materials for supercapacitors without sacrificing their rate capability, especially at high mass‐loading, is a challenge because of the sluggish electrochemical kinetics of compact graphene electrodes. Here, a compact graphene monolith (dense graphene ribbons [DGRs]‐0.6) was fabricated by using graphene oxide ribbons as building blocks and deliberately harmonizing the graphene primitive unit structure and interlayer spacing. The DGRs‐0.6 contained abundant oxygen‐containing functional groups and a highly interconnected pore structure, resulting in a large ion‐accessible surface area, a high packing density, and fast electron/ion transport pathways. The DGRs‐0.6 electrode exhibited a volumetric capacitance of 316 F cm–3, a rate capability of 220 F cm–3 at 100 A g–1, and ultralong cycling stability. For a mass loading of 11 mg cm−2, the DGRs‐0.6 delivered volumetric capacitances of 150 F cm−3 at 1 A g−1 and 109 F cm−3 at 50 A g−1. The good rate capability and volumetric capacitance of DGRs‐0.6 under high mass loading demonstrate its potential as a supercapacitor electrode for practical applications.
Anthropocentric, biospheric and egobiocentric environmental values and green product purchase intention: The mediating effect of environmental identity
Authors: Perera Chamila R. , Kalantari Daronkola Hassan , Johnson Lester W. 
Published: August 2022

AbstractThis study investigates how the relationship between environmental values (anthropocentric, biospheric and egobiocentric) and green product purchase intention is mediated by environmental identity. Asurvey conducted online involving 564 Australians informs the findings. Data analysis is performed using AMOS, a structural equation modelling package. Out of the three environmental values, egobiocentric values have the strongest influence on environmental identity followed by anthropocentric values, whilst biospheric values do not affect environmental identity. Whilst environmental identity fully mediates the relationship between anthropocentric and egobiocentric values and green product purchase intention, it does not mediate the relationship between biospheric values and green product purchase intention. Biospheric values have a direct relationship with green product purchase intention. The study provides valuable insights on developing green marketing strategies by revealing that unlike individuals with anthropocentric and egobiocentric values, individuals with biospheric values cannot be promoted to purchase green products as a form of environmental identity expression.
Hypertrophic lichen planus on lip mimicking SCC
Authors: Mozafari Nikoo , Bidari‐Zerehpoosh Farahnaz , Movahedi Mahdiyeh , Dadkhahfar Sahar 
Published: August 2022

AbstractThe lichen planus (LP) is an inflammatory and immune‐mediated disorder that can affect the hair, mucous membranes, nails, and skin. Lichen planus rarely affects the lips. In cases of lip involvement, it presents as radiated streaks, lace‐like papules, and erosions. There is no report of lip LP presenting as hypertrophic plaque. Here, we report interesting and rare clinical presentations of LP in a 45‐year‐old male patient that presented with a verrucous hyperkeratotic plaque on the lower lip mimicking squamous cell carcinoma. However, oral examination revealed, reticulated white patches on the bilateral buccal mucosa, and a biopsy of the lip lesion revealed lichenoid dermatitis which led to the diagnosis of hypertrophic lichen planus. Familiarity with the different clinical presentations of LP and its variants is essential for prompt diagnosis and effective treatment.
Electronic and ionic properties of sintered cathode of LiNi0.6Mn0.2Co0.2O2 (NCM622)
Authors: Waetzig Katja , Huettl Juliane , Goedeke Dieter , Schilm Jochen , Nikolowski Kristian , Partsch Mareike 
Published: August 2022

AbstractLi‐ion solid‐state batteries have the potential for high energy densities and improved safety. Oxidic all solid‐state batteries require co‐sintering of the Li‐ion conductive solid electrolyte, the active electrode material, and an electronic conductive additive to give a composite electrode. A first step for the realization of this complex system is the study of the sintering behavior of the active material itself as a single‐phase component and to investigate the electrochemical activity as well as the electronic properties after heat treatment. In this study monolithic NCM622 cathodes with a thickness of about 90 μm were sintered at temperatures up to 900°C by using a low‐melting glass as sintering additive. For these ceramic cathodes sintered at T = 800°C, an electronic conductivity of 3.0 × 10–3 S cm–1 and six orders of magnitude lower Li‐ion conductivity of about 10–9 S cm–1 were determined by DC conductivity measurement. To investigate the electrochemical performance of the sintered cathode material, the porous microstructure was infiltrated with liquid electrolyte and a charging capacity of 140 mAh g–1 (92% of the theoretical capacity) was measured with C/50 cycling rate. In comparison, the electrochemical performance without infiltration of a Li‐ion conductive liquid was tested with polyethylene oxide as polymeric separator. With these measurements the ability of the sintered cathode to charge/discharge as well as to provide sufficient high electronic conductivity has been demonstrated.
Point‐to‐face contact heterojunctions: Interfacial design of 0D nanomaterials on 2D g‐C3N4 towards photocatalytic energy applications
Authors: Tan Xin‐Quan , Ng Sue‐Faye , Mohamed Abdul Rahman , Ong Wee‐Jun 
Published: August 2022

AbstractGreen energy generation is an indispensable task to concurrently resolve fossil fuel depletion and environmental issues to align with the global goals of achieving carbon neutrality. Photocatalysis, a process that transforms solar energy into clean fuels through a photocatalyst, represents a felicitous direction toward sustainability. Eco‐rich metal‐free graphitic carbon nitride (g‐C3N4) is profiled as an attractive photocatalyst due to its fascinating properties, including excellent chemical and thermal stability, moderate band gap, visible light‐active nature, and ease of fabrication. Nonetheless, the shortcomings of g‐C3N4 include fast charge recombination and limited surface‐active sites, which adversely affect photocatalytic reactions. Among the modification strategies, point‐to‐face contact engineering of 2D g‐C3N4 with 0D nanomaterials represents an innovative and promising synergy owing to several intriguing attributes such as the high specific surface area, short effective charge‐transfer pathways, and quantum confinement effects. This review introduces recent advances achieved in experimental and computational studies on the interfacial design of 0D nanostructures on 2D g‐C3N4 in the construction of point‐to‐face heterojunction interfaces. Notably, 0D materials such as metals, metal oxides, metal sulfides, metal selenides, metal phosphides, and nonmetals on g‐C3N4 with different charge‐transfer mechanisms are systematically discussed along with controllable synthesis strategies. The applications of 0D/2D g‐C3N4‐based photocatalysts are focused on solar‐to‐energy conversion via the hydrogen evolution reaction, the CO2 reduction reaction, and the N2 reduction reaction to evaluate the photocatalyst activity and elucidate reaction pathways. Finally, future perspectives for developing high‐efficiency 0D/2D photocatalysts are proposed to explore potential emerging carbon nitride allotropes, large‐scale production, machine learning integration, and multidisciplinary advances for technological breakthroughs.
Palladium‐Catalyzed Arylfluorination of Alkenes: A Powerful New Approach to Organofluorine Compounds
Authors: Remete Attila Márió , Nonn Melinda , Kiss Loránd 
Published: August 2022

AbstractFluorine incorporation into organic molecules is often beneficial to their absorption, distribution, metabolism, and excretion (ADME) properties or bioactivity. As a consequence, organofluorine compounds have become quite common amongst drugs and agrochemicals, and their preparation is a highly important topic in both synthetic organic chemistry and pharmaceutical chemistry. One of the newly developed methods for accessing organofluorine compounds is Pd‐catalyzed arylfluorination of alkenes. It is an olefin difunctionalization process that simultaneously introduces an aryl group and a fluorine atom into an alkene framework. This review provides a concise overview of this powerful and versatile method.
OER‐073: A multicenter phase 2 study evaluating the role of pazopanib in angiosarcoma
Authors: Thiebaud Julio Alvarenga , Ravi Vinod , Litwin Samuel , Schuetze Scott M. , Movva Sujana , Agulnik Mark , Kraft Andrew S. , Tetzlaff Eric D. , Somaiah Neeta , von Mehren Margaret 
Published: August 2022

BackgroundAngiosarcomas are rare mesenchymal sarcomas that can present as primary cutaneous or noncutaneous disease. They express a variety of vascular endothelial growth factor receptors. The authors hypothesized that the treatment of angiosarcoma with pazopanib, a multikinase inhibitor with activity against vascular endothelial growth factor receptors, would result in disease response and prolonged disease stabilization.MethodsThis was an open‐label, phase 2 trial of pazopanib in patients who had incurable angiosarcoma. The co‐primary end points were response according to the Response Evaluation Criteria in Solid Tumors and progression‐free survival (PFS) at 3 months. The starting dose of pazopanib was 800 mg daily.ResultsTwenty‐nine patients were accrued between 2011 and 2018, and 22 patients were evaluable for response. Toxicities were similar to those identified in prior reports. There was one partial response (3%), and the clinical benefit rate (including complete responses, partial responses, and stable disease) was 48%, which was observed more frequently in patients who had cutaneous disease. The median PFS was 14.4 weeks, and the 3‐month PFS rate determined by Kaplan–Meier estimate was 54.6% (95% CI, 36.0%–82.9%), meeting the primary study objective. The Kaplan–Meier overall survival estimate was 16.1 months.ConclusionsPazopanib therapy in patients who had incurable angiosarcoma was associated with meaningful disease control, especially in those who had cutaneous disease with limited objective responses.Lay Summary

Angiosarcoma is a rare cancer that can be found on the skin or in internal organs.

This study tested pazopanib, an oral targeted medication, to determine its benefit in patients with angiosarcoma who could not undergo the removal of their tumors by surgery.

Pazopanib treatment was safe, and no new side effects were reported.

The study showed that pazopanib controlled tumor growth in one half of patients at 3 months and was more common in angiosarcomas of the skin; it led to tumor shrinkage in a minority of patients (1 of 29).
A distributed self‐organising node deployment algorithm for mobile sensor networks
Authors: Sadeghi Ghahroudi Mahsa , Shahrabi Alireza , Boutaleb Tuleen 
Published: August 2022

SummaryProviding the appropriate coverage is quite essential for the effective functioning of many applications in Wireless Sensor Networks. Therefore, the efficiency of node deployment algorithms to supply the requested coverage is of high significance. In this paper, inspired by the equilibrium of molecules, a novel node deployment algorithm, called Smart Self‐organising Node Deployment (SSND), is proposed to provide maximum coverage. Despite other proposed algorithms, which provide coverage based on the collective movement of nodes with massive energy consumption, SSND moves one sensor in every neighbourhood at each step to reduce the sensor nodes' movement and hence the energy consumption. The chosen sensor nodes at each time step are distributedly determined by an eligibility function to reduce the non‐essential movements while improving the accuracy of the reported locations of neighbours. Our extensive simulation study shows that SSND can achieve up to 30%coverage improvement compared to those of other algorithms in most scenarios and provides an adequate trade‐off between coverage and energy consumption.
Cutaneous melanoma: An update on pathogenesis, prevention, and treatment
Authors: Frech Fabio S. , Bommareddy Kanthi , Hernandez Loren , Dreyfuss Isabella , Urbonas Rebecca , Nouri Keyvan 
Published: August 2022

AbstractAlthough the cause for the rise in melanoma incidence remains a topic of debate, its potentially aggressive nature necessitates a continual update on the pathophysiologic mechanisms of disease and current guidelines for management. Akin to other cutaneous malignancies, sun exposure remains a crucial risk factor in the development of different melanoma subtypes. There are specific non‐UV associated mutations that are commonly found in most melanomas and some nevi, such as B‐RAF V600E, that may represent an initial insult of a multistep process that eventually leads to progression of the lesion into a more aggressive phenotype. The standard of care for early melanoma management remains surgical excision with wide margins, however management changes with more advanced lesions by the addition of imaging, sentinel lymph node biopsies, genetic testing, immune, and targeted therapy. Different novel treatment regimens for advanced unresectable melanomas are being investigated with the use of targeted therapies and vaccines. Novel screening technology using artificial intelligence for detection of melanoma is currently being developed but remains in its early stages with its effectiveness being significantly lower compared to clinicians. As such, melanoma prevention and early detection through skin examinations remain crucial to avoid potentially deadly complications from more advanced lesions.
Selective Cyclopropanation/Aziridination of Olefins Catalyzed by Bis(pyrazolyl)borate Cu(I) Complexes
Authors: Zhao Qianyi , Yao Qiu‐Yue , Zhang Yan‐Jiao , Xu Ting , Zhang Jie , Chen Xuenian 
Published: August 2022

AbstractBis(pyrazolyl)borate complexes [BBN(pzR)2]Cu(I) were evaluated as catalysts in the reaction of carbene/nitrene transfer and addition to C=C bonds of a wide range of aromatic, heterocyclic and aliphatic olefins. The complexes exhibit high catalytic efficiency and selectivity in both processes.
AOP Report: Thyroperoxidase Inhibition Leading to Altered Visual Function in Fish Via Altered Retinal Layer Structure
Authors: Gölz Lisa , Baumann Lisa , Pannetier Pauline , Braunbeck Thomas , Knapen Dries , Vergauwen Lucia 
Published: August 2022

ABSTRACT
Thyroid hormones (THs) are involved in the regulation of many important physiological and developmental processes, including vertebrate eye development. Thyroid hormone system–disrupting chemicals (THSDCs) may have severe consequences, because proper functioning of the visual system is a key factor for survival in wildlife. However, the sequence of events leading from TH system disruption (THSD) to altered eye development in fish has not yet been fully described. The development of this adverse outcome pathway (AOP) was based on an intensive literature review of studies that focused on THSD and impacts on eye development, mainly in fish. In total, approximately 120 studies (up to the end of 2021) were used in the development of this AOP linking inhibition of the key enzyme for TH synthesis, thyroperoxidase (TPO), to effects on retinal layer structure and visual function in fish (AOP-Wiki, AOP 363). In a weight-of-evidence evaluation, the confidence levels were overall moderate, with ample studies showing the link between reduced TH levels and altered retinal layer structure. However, some uncertainties about the underlying mechanism(s) remain. Although the current weight-of-evidence evaluation is based on fish, the AOP is plausibly applicable to other vertebrate classes. Through the re-use of several building blocks, this AOP is connected to the AOPs leading from TPO and deiodinase inhibition to impaired swim bladder inflation in fish (AOPs 155–159), together forming an AOP network describing THSD in fish. This AOP network addresses the lack of thyroid-related endpoints in existing fish test guidelines for the evaluation of THSDCs. Environ Toxicol Chem 2022;41:2632–2648. © 2022 SETAC
Fish Embryo Acute Toxicity Testing and the RTgill-W1 Cell Line as In Vitro Models for Whole-Effluent Toxicity (WET) Testing: An In Vitro/In Vivo Comparison of Chemicals Relevant for WET Testing
Authors: Scott Justin , Grewe Ryan , Minghetti Matteo 
Published: August 2022

Abstract
The fathead minnow (Pimephales promelas) fish embryo acute toxicity (FET) test was compared to the fish gill cells (RTgill-W1) in vitro assay and to the fish larvae acute toxicity test to evaluate their sensitivity for whole-effluent toxicity (WET) testing. The toxicity of 12 chemicals relevant for WET testing was compared as proof of principle. The concentrations lethal to 50% of a population (LC50) of embryos were compared to those in fish larvae and to the 50% effect concentration (EC50) in RTgill-W1 cells from previous literature. Along with traditional FET endpoints (coagulation, somite development, tail detachment, and heartbeat), cardiotoxicity was evaluated for WET applicability. Heart rate was measured at LC20 and LC50 values of six subselected chemicals (Cd, Cu, Ni, ammonia, 3,4-dichloraniline, and benzalkonium chloride). In addition, the toxicity of Cd and Ni was evaluated in RTgill-W1 cells exposed in a hypoosmotic medium to evaluate the effect that osmolarity may have on metal toxicity. A significant correlation was found between the FET and larvae LC50 values but not between the RTgill-W1 EC50 and FET LC50 values. Although sensitivity to Ni and Cd was found to increase with hypoosmotic conditions for FET and RTgill-W1 cells, a correlation was only found with removal of Ni from the analysis. Hypoosmotic conditions increased sensitivity with a significant correlation between RTgill-W1 cells and larvae. Cardiotoxicity was shown in three of the five subselected chemicals (Cd, Cu, and 3,4-dichloroaniline). Overall, both in vitro alternative models have shown good predictability of toxicity in fish in vivo for WET chemicals of interest. Environ Toxicol Chem 2022;41:2721–2731. © 2022 SETAC
Profiling of syngeneic mouse HCC tumor models as a framework to understand anti–PD‐1 sensitive tumor microenvironments
Authors: Zabransky Daniel J. , Danilova Ludmila , Leatherman James M. , Lopez‐Vidal Tamara Y. , Sanchez Jessica , Charmsaz Soren , Gross Nicole E. , Shin Sarah , Yuan Xuan , Hernandez Alexei , Yang Hongqui , Xavier Stephanie , Shu Daniel , Saeed Ali , Munjal Kabeer , Kamdar Zeal , Kagohara Luciane T. , Jaffee Elizabeth M. , Yarchoan Mark , Ho Won Jin 
Published: August 2022

Background and Aims:
The treatment of hepatocellular carcinoma (HCC) has been transformed by the use of immune checkpoint inhibitors. However, most patients with HCC do not benefit from treatment with immunotherapy. There is an urgent need to understand the mechanisms that underlie response or resistance to immunotherapy for patients with HCC. The use of syngeneic mouse models that closely recapitulate the heterogeneity of human HCC will provide opportunities to examine the complex interactions between cancer cells and nonmalignant cells in the tumor microenvironment.

Approach and Results:
We leverage a multifaceted approach that includes imaging mass cytometry and suspension cytometry by time of flight to profile the tumor microenvironments of the Hep53.4, Hepa 1‐6, RIL‐175, and TIBx (derivative of TIB‐75) syngeneic mouse HCC models. The immune tumor microenvironments vary across these four models, and various immunosuppressive pathways exist at baseline in orthotopic liver tumors derived from these models. For instance, TIBx, which is resistant to anti–programmed cell death protein 1 therapy, contains a high proportion of “M2‐like” tumor‐associated macrophages with the potential to diminish antitumor immunity. Investigation of The Cancer Genome Atlas reveals that the baseline immunologic profiles of Hep53.4, RIL‐175, and TIBx are broadly representative of human HCCs; however, Hepa 1‐6 does not recapitulate the immune tumor microenvironment of the vast majority of human HCCs.

Conclusions:
There is a wide diversity in the immune tumor microenvironments in preclinical models and in human HCC, highlighting the need to use multiple syngeneic HCC models to improve the understanding of how to treat HCC through immune modulation.
Injectable hydrogel as a carrier of vancomycin and a cathelicidin‐derived peptide for osteomyelitis treatment
Authors: Machado Alexandra , Pereira Isabel , Silva Vanessa , Pires Isabel , Prada Justina , Poeta Patrícia , Costa Luís , Pereira José Eduardo , Gama Miguel 
Published: August 2022

AbstractA local drug delivery system that attempts to find a suitable balance between antimicrobial and regenerative actions was developed for osteomyelitis treatment (OM). This system combines the angiogenic and immunomodulatory peptide LLKKK18 (LL18) and vancomycin hydrochloride (VH), loaded into an injectable oxidized dextrin (ODEX)‐based hydrogel (HG). In vitro cytotoxicity was analyzed in MC3T3‐E1 pre‐osteoblasts and erythrocytes. The kinetics of LL18 release was studied. Antimicrobial activity was assessed in vitro against a clinical Methicillin‐Resistant Staphylococcus aureus (MRSA) strain. A rat model of acute OM was developed by direct inoculation into a tibia defect, concomitantly with the implantation of the drug‐loaded HG. The local bioburden was quantified and damage in surrounding tissues was examined histologically. In vitro, ODEX‐based HG displayed a safe hemolytic profile. Half of LL18 (53%) is released during the swelling phase at physiological pH, then being gradually released until complete HG degradation. LL18‐loaded HG at 300 μM was the most effective peptide formulation in decreasing in vivo infection among concentrations ranging from 86 to 429 μM. The histopathological scores observed in vivo varied with the LL18 concentration in a dose‐dependent manner. VH at 28 mM completely eradicated bacteria, although with substantial tissue injury. We have found that sub‐millimolar doses of VH combined with LL18 at 300 μM may suffice to eradicate the infection, with reduced tissue damage. We propose an easy‐to‐handle, shape‐fitting HG formulation with the potential to treat MRSA‐infected bone with low VH doses associated with LL18.