bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood maltreatment is associated with cortical thinning in people with eating disorders
Authors: Cascino Giammarco , Canna Antonietta , Russo Andrea Gerardo , Monaco Francesco , Esposito Fabrizio , Di Salle Francesco , Monteleone Palmiero , Monteleone Alessio Maria 
Published: July 2022

AbstractChildhood maltreatment (CM) is a non-specific risk factor for eating disorders (ED) and is associated with a greater severity in their clinical presentation and poorer treatment outcome. These data suggest that maltreated people with ED may be biologically other than clinically different from non-maltreated people. The aim of the present study was to investigate cortical thickness (CT), a possible biomarker of neurodevelopment, in people with ED with or without history of CM and in healthy women. Twenty-four healthy women, 26 with anorexia nervosa and 24 with bulimia nervosa underwent a 3T MRI scan. All participants filled in the childhood trauma questionnaire. All neuroimaging data were processed by FreeSurfer. Twenty-four participants with ED were identified as maltreated and 26 participants with ED as non-maltreated. All healthy women were non-maltreated. Compared to healthy women, maltreated people with ED showed lower CT in the left rostral anterior cingulate gyrus, while compared to people with ED without history of CM showed lower CT values in the left superior frontal and in right caudal middle frontal and superior parietal gyri. No significant differences emerged in CT measures between healthy women and people with ED without history of CM. The present findings show for the first time that in adult people with ED childhood maltreatment is associated with cortical thinning in areas implicated in the modulation of brain processes that are acknowledged to play a role in the psychopathology of ED.
An update on ophthalmological perspectives in oculodermal melanocytosis (Nevus of Ota)
Authors: Abdolrahimzadeh Solmaz , Pugi Damiano Maria , Manni Priscilla , Iodice Clemente Maria , Di Tizio Federico , Persechino Flavia , Scuderi Gianluca 
Published: July 2022

AbstractPurposeTo provide a review of the literature on oculodermal melanocytosis (ODM) with a focus on the diagnostic and therapeutic implications of multimodal imaging techniques in the management of ophthalmic complications.MethodsThe authors carried out a literature search on PubMed, Medline, and Scopus of English language articles published on ODM through August 2021. This review presents traditional and novel diagnostic methods in the diagnosis and follow-up of patients with particular emphasis on addressing the role of imaging in the management of the ophthalmic complications of the condition towards improving current practice patterns.ResultsODM is a rare, prevalently unilateral, congenital condition that presents with brown or blue/gray flat asymptomatic lesions of the skin, mucosae, episclera/sclera, and uvea localized within the territory of distribution of the ophthalmic and mandibular branches of the trigeminal nerve. Glaucoma and predisposition to uveal melanoma are the main ophthalmic complications. Diagnosis and management are through comprehensive opthalmological examination and traditional imaging methods such as ultrasonography and fluorescein/indocyanine green angiography as pigmentation of the fundus can conceal subtle retinal and choroidal alterations. Anterior segment optical coherence tomography and ultrasound biomicroscopy are used to evaluate the anterior segment and the ciliary body in the presence of glaucoma or melanoma of the anterior uveal tract. Fundus autofluorescence and retinal pigment epithelium (RPE) alterations are of aid in the differential diagnosis between choroidal nevi and melanoma. Enhanced depth imaging spectral domain optical coherence tomography offers outstanding in vivo evaluation of the dimensions and details of tumors or nevi and surrounding choroidal tissues and small choroidal melanomas may show distortions of the retinal and sub-retinal profile, presence of intra and sub-retinal fluid, abnormalities of the RPE, and compression of the choriocapillaris.ConclusionsNovel multimodal imaging techniques are significant in the diagnosis and management of the ophthalmic complications of ODM. Fundus autofluorescence and enhanced depth spectral domain optical coherence tomography have adjunctive value in the detection of early-stage melanoma and differential diagnosis between nevi and melanoma. Awareness of current and emerging imaging techniques can propagate improved standardized definition and assessment of the complications of ODM.
Urban thermal comfort trends in Sri Lanka: the increasing overheating problem and its potential mitigation
Authors: Simath Shifana , Emmanuel Rohinton 
Published: July 2022

AbstractUrban dwellers experience overheating due to both global and urban warming. The rapid urbanisation, especially in hot, humid cities, lead to greater exposure to heat risk, both due to increasing urban populations as well as overheating due to global/urban warming. However, a nation-wide exploration of thermal comfort trends, especially in the hot, humid tropics, remains relatively unexplored. In this paper, we explore the recent historical trends (1991–2020) in outdoor thermal comfort across the entire island of Sri Lanka and evaluate the likely effects of known urban climate mitigation strategies — shade and vegetative cover. We find that ‘very strong heat stress’ is moving towards ‘extreme heat stress’ that was barely registered in 1990s and is now common across two-thirds of the landmass of Sri Lanka in the hottest month (April). Even in the coolest month (January), ‘moderate heat stress’ unknown in the 1990s is now becoming a common trend across the most densely populated parts of the country. High shading and vegetation could reduce heat stress, even in the hottest month, but its utility will diminish as the warming continues in future. As such, policies to reduce global warming needs to be urgently pursued while simultaneously adapting to urban warming in Sri Lanka.
Nordic forest management towards climate change mitigation: time dynamic temperature change impacts of wood product systems including substitution effects
Authors: Schulte Maximilian , Jonsson Ragnar , Hammar Torun , Stendahl Johan , Hansson Per-Anders 
Published: July 2022

AbstractClimate change mitigation trade-offs between increasing harvests to exploit substitution effects versus accumulating forest carbon sequestration complicate recommendations for climate beneficial forest management. Here, a time dynamic assessment ascertains climate change mitigation potential from different rotation forest management alternatives across three Swedish regions integrating the forest decision support system Heureka RegWise with a wood product model using life cycle assessment data. The objective is to increase understanding on the climate effects of varying the forest management. Across all regions, prolonging rotations by 20% leads on average to the largest additional net climate benefit until 2050 in both, saved emissions and temperature cooling, while decreasing harvests by 20% leads to the cumulatively largest net climate benefits past 2050. In contrast, increasing harvests or decreasing the rotation period accordingly provokes temporally alternating net emissions, or slight net emission, respectively, regardless of a changing market displacement factor. However, future forest calamities might compromise potential additional temperature cooling from forests, while substitution effects, despite probable prospective decreases, require additional thorough and time explicit assessments, to provide more robust policy consultation.
Inner Flame Front Structures and Burning Velocities of Premixed Turbulent Planar Ammonia/Air and Methane/Air Flames
Authors: Tamadonfar Parsa , Karimkashi Shervin , Kaario Ossi , Vuorinen Ville 
Published: July 2022

AbstractAmmonia ($$\mathrm {NH_3}$$NH3) has attracted interest as a future carbon-free synthetic fuel due to its economic storage and transportation. In this study, quasi direct numerical simulations (quasi-DNS) with detailed-chemistry have been performed in 3-D to examine the flame thickness and assess the validity of Damköhler’s first hypothesis for premixed turbulent planar ammonia/air and methane/air flames under different turbulence levels. The Karlovitz number is systematically changed from 4.26 to 12.06 indicating that all the test conditions are located within the thin reaction zones combustion regime. Results indicate that the ensemble average values of the preheat zone thickness deviate slightly from the thin laminar flamelet assumption, while the reaction zone regions remain relatively intact. Following the balance equation of reaction progress variable gradient, normal strain rate and the tangential diffusion component of flame displacement speed variation in the normal direction to the flame surface are found to be responsible for thickening the flame. However, the sum of reaction and normal diffusion components of flame displacement speed variation in the normal direction to the flame surface is in charge of flame thinning for ammonia/air and methane/air flames. In addition, the validity of Damköhler’s first hypothesis is confirmed by indicating that the ratio of the turbulent burning velocity to the unstrained premixed laminar burning velocity is relatively equal to the ratio of the wrinkled to the unwrinkled flame surface area. Furthermore, the probability density functions of the density-weighted flame displacement speed show that the bulk of flame elements propagate identical to the unstrained premixed laminar flame.
Molecular characterization of an embryonal rhabdomyosarcoma occurring in a patient with Kabuki syndrome: report and literature review in the light of tumor predisposition syndromes
Authors: Aukema Sietse M. , Glaser Selina , van den Hout Mari F. C. M. , Dahlum Sonja , Blok Marinus J. , Hillmer Morten , Kolarova Julia , Sciot Raf , Schott Dina A. , Siebert Reiner , Stumpel Constance T. R. M. 
Published: July 2022

AbstractKabuki syndrome is a well-recognized syndrome characterized by facial dysmorphism and developmental delay/intellectual disability and in the majority of patients a germline variant in KMT2D is found. As somatic KMT2D variants can be found in 5–10% of tumors a tumor predisposition in Kabuki syndrome is discussed. So far less than 20 patients with Kabuki syndrome and a concomitant malignancy have been published. Here we report on a female patient with Kabuki syndrome and a c.2558_2559delCT germline variant in KMT2D who developed an embryonal rhabdomyosarcoma (ERMS) at 10 years. On tumor tissue we performed DNA-methylation profiling and exome sequencing (ES). Copy number analyses revealed aneuploidies typical for ERMS including (partial) gains of chromosomes 2, 3, 7, 8, 12, 15, and 20 and 3 focal deletions of chromosome 11p. DNA methylation profiling mapped the case to ERMS by a DNA methylation-based sarcoma classifier. Sequencing suggested gain of the wild-type KMT2D allele in the trisomy 12. Including our patient literature review identified 18 patients with Kabuki syndrome and a malignancy. Overall, the landscape of malignancies in patients with Kabuki syndrome was reminiscent of that of the pediatric population in general. Histopathological and molecular data were only infrequently reported and no report included next generation sequencing and/or DNA-methylation profiling. Although we found no strong arguments pointing towards KS as a tumor predisposition syndrome, based on the small numbers any relation cannot be fully excluded. Further planned studies including profiling of additional tumors and long term follow-up of KS-patients into adulthood could provide further insights.
Conformance-oriented Predictive Process Monitoring in BPaaS Based on Combination of Neural Networks
Authors: Wang Jiaojiao , Chang Victor , Yu Dongjin , Liu Chang , Ma Xiaoyu , Yu Dingguo 
Published: July 2022

AbstractAs a new cloud service for delivering complex business applications, Business Process as a Service (BPaaS) is another challenge faced by cloud service platforms recently. To effectively reduce the security risk caused by business process execution load in BPaaS, it is necessary to detect the non-compliant process executions (instances) from tenants in advance by checking and monitoring the conformance of the executing process instances in real-time. However, the vast majority of existing conformance checking techniques can only be applied to the process instances that have been executed completely offline and only focus on the conformance from the single control-flow perspective. We develop an extensible multi-perspective conformance measurement method to address these issues first and then investigate the predictive conformance monitoring approach by automatically constructing an online multi-perspective conformance prediction model based on deep learning techniques. In addition, to capture more decisive features in the model from both local information and long-distance dependency within an executed process instance, we propose an approach, called CNN-BiGRU, by combining Convolutional Neural Network (CNN) with a variant and enhancement of Recurrent Neural Network (RNN). Extensive experiments on two data sets demonstrate the effectiveness and efficiency of the proposed CNN-BiGRU.
Hands on programming: Teachers’ use of Metaphors in gesture and Speech make Abstract concepts tangible
Authors: Larsson Andreas , Stolpe Karin 
Published: July 2022

AbstractMetaphors in gesture and speech play a pivotal role in the way that programming concepts are presented in the classroom. However, little is known about the function of teachers’ metaphors in practice. This study aims to explore teachers’ use of metaphors in gesture and speech in a lecture on programming. Based on video observations of three upper secondary teachers, we employ Metaphor Identification Procedure (MIP) and Metaphor Identification for Gesture Guidelines (MIG-G) as methodological tools for identifying metaphoric speech and gestures related to programming concepts. The results of the study reveal that the gestures of the three teachers mainly function in two ways: (1) to add spatial properties to a programming concept and (2) to provide additional imagery for a programming concept. Consequently, the gestures identified in this study reduce the communicative burden of teachers’ speech. Furthermore, the study reveals that teachers’ gestures serve as means for making abstract concepts more tangible. For example, gestures concerning the abstract term “data” can generally be related to an object that could be received or moved. Hence, despite its metaphorical origin, data could be considered a graspable aspect of programming. Furthermore, spatial gestures enable the teachers to communicate programming processes in a tangible way, for example assigning programming processes a forward direction. Theoretical implications, potential implications for teaching and future research are discussed in the paper.
Recipient perspectives on the impact of home adaptations in later life in England
Authors: Aitken Dominic , Wilson-Menzfeld Gemma , Hodgson Philip , Bailey Catherine 
Published: July 2022

AbstractThe ability for adults to make changes to their home environments as they age to better suit their needs is of increasing importance. It is crucial that the full gamut of impacts from adaptations is understood in order to facilitate comprehensive evaluations which can fully capture their utility. Most previous studies in the field have used a quantitative methodology. Drawing on qualitative interviews, with some informed by wearable camera data, we explore perspectives on the impact of home adaptations from recipients aged 65 and over (n = 30). These are discussed around five themes: restorative outcomes; preventative outcomes; social outcomes; impacts on others; and home perceptions. The research emphasises several under-explored outcomes from adaptations including impacts related to social participation, care provision, relocation, perceptions of the home, service awareness and other household members. We argue that any future evaluation framework needs to comprehensively capture potential outcomes based on the lived experience of recipients in order to fully appreciate both negative and positive impacts from home adaptations.
College Students’ motivational beliefs and use of goal-oriented control strategies: Integrating two theories of motivated behavior
Authors: von Keyserlingk Luise , Rubach Charlott , Lee Hye Rin , Eccles Jacquelynne S. , Heckhausen Jutta 
Published: July 2022

AbstractIn college, students often encounter situations in which they struggle to meet their academic goals in difficult courses. We integrate the Motivational Theory of Life-Span Development and Situated Expectancy-Value Theory to investigate how motivational beliefs and experiences in a difficult course predict the use of goal engagement oriented and goal adjustment oriented control strategies that can help students stay engaged in challenging courses. We used survey data collected in two academic quarters at a public university in the U.S. (N = 231). Students who perceived their midterm exam as more difficult than expected and students with higher course-specific subjective task values reported using more goal engagement oriented and goal adjustment oriented control strategies. Students with higher course-specific ability beliefs were less likely to use goal adjustment strategies. Results further showed that students planned to use control strategies depending on their experienced setbacks or success in exams. Findings provide important insights into how motivational orientations and course experiences relate to adaptive and goal-oriented behavior in college courses.
Genetics of Cushing’s disease: from the lab to clinical practice
Authors: Theodoropoulou Marily , Reincke Martin 
Published: July 2022

AbstractCushing’s disease is a rare, but devastating condition, caused by corticotroph tumors. It rarely manifests as syndrome and very few isolated cases present with germline mutations. Instead, the vast majority of corticotroph tumors are sporadic monoclonal neoplasms. At present, the major recurrent somatic driver mutations are found in the USP8 gene, which encodes for a deubiquitinase that rescues proteins regulating ACTH synthesis. Almost half of functional corticotroph tumors carry somatic USP8 mutations that associate with a distinct transcriptomic and clinical profile. Other genes mutated in a small fraction of corticotroph tumors include the deubiquitinase encoding gene USP48 and the glucocorticoid receptor expressing NR3C1. Recent reports on somatic TP53 and ATRX mutations in corticotroph macroadenomas and carcinomas indicate that within specific patient subpopulations they are not as rare as assumed.
Trust in the Third Space of Science Education
Authors: Toscano Maurizio , Millar Victoria 
Published: July 2022

AbstractThis paper investigates rationality and its relationship to trust in science in the context of three proposed spaces of science education: the formal, informal and casual. It begins with the place of science as a trusted institution and its role in formal and informal education across the world. Through educational systems, we have come to trust that students are being educated about science and its trustworthiness. However, formal and informal education spaces are not the only spaces in which individuals and society seek science understanding. While the science education literature has long concerned itself with science education in these spaces, this paper proposes a third space, the casual space. The casual space is decentralised and provides access to a range of norms and explanations about the world. We investigate how each of the formal, informal and casual spaces privileges particular forms of rationality as a means for understanding trust in science in each of these spaces. This paper considers the implications for education’s response to the challenge of equipping students to make rational judgements about science.
Trends in osteoporosis diagnosis and management in Australia
Authors: Smith Leon , Wilson Stephen 
Published: July 2022

Abstract
Summary

Trends in bone mineral density monitoring, and drug treatment for osteoporosis, in Australia were examined. Rates of DEXA scanning have increased in response to changes to government policy affecting reimbursement. The drug denosumab is being utilised at an increasing rate, while bisphosphonate use has declined. Osteoporosis prevalence remained stable over the same timeframe, while rate of hip fractures declined, suggesting that introduction of osteoporosis screening was associated with a reduction in adverse osteoporosis outcomes, but may also have been associated with overutilisation.

Introduction
Radiology interventions to diagnose and medications to manage osteoporosis in Australia are reimbursed under the Medicare benefits schedule (MBS) and Pharmaceutical Benefits Scheme (PBS). Monitoring of these databases enables changes in utilisation of these practices to be monitored over time.

Methods
This study examined rates of utilisation for bone mineral density (BMD) measurement and osteoporosis pharmacotherapy subsidised under the MBS. Rates of osteoporosis and hip fracture were estimated using data reported by the Australian Bureau of Statistics (ABS) and Australian Institute for Health and Welfare (AIHW).

Results
Rates of BMD measurement increased since the technology was first reimbursed, with changes to policy regarding reimbursement for screening for individuals over 70 leading to an increase in BMD measurement after 2007. Prescribing rates also increased over time, initially with the introduction of oral bisphosphonates and subsequently for denosumab, which has subsequently become the most commonly prescribed agent for osteoporosis management in Australia, while bisphosphonate use has declined. Osteoporosis prevalence in Australia has remained relatively static at 3–4% of the population since 2001 to 2017, while rates of minimal trauma hip fracture hospitalisations have declined from 195 per 100,000 to 174 per 100,000 in the same timeframe.

Conclusion
Available data indicates that osteoporosis screening rates changed over time from 2001 to 2018 and that changes to government policy had a significant effect on the rates at which screening was performed. Over the same timeframe, there was a sustained reduction in hip fracture hospitalisation rates, with no change to reported osteoporosis prevalence. This suggests that policy changes permitting unlimited access to BMD measurement were associated with a reduction in osteoporotic fractures, but may also have been associated with overutilisation. Prospective studies to assess the efficacy of specific policies to ensure screening is performed in accordance with best-practice guidelines may be desirable.