bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety Of Tranexamic Acid Use In Pediatric Patients Undergoing Spinal Fusion Surgery: A Retrospective Comparative Cohort Study
Authors: Ivasyk Iryna , Chatterjee Abhinaba , Jordan Catherine , Geiselmann Matthew T. , Chang Peter S. , Kamel Hooman , Khormaee Sariah 
Published: February 2022

Abstract
Background: Pediatric spinal fusion may be associated with significant intraoperative blood loss, leading to complications from transfusion, hypoperfusion and coagulopathy. One emerging strategy to mediate these risks is by utilization of the anti-fibrinolytic agent tranexamic acid (TXA). However, concerns regarding potential adverse reactions, specifically postoperative seizures and thrombotic events, still exist. To assess these risks, we examined the perioperative morbidity of TXA use in a large national database. Methods: Retrospective data from pediatric patients (age 18 years or younger), discharged between January 2013 to December 2015, who underwent primary or revision posterior spinal fusions, was collected from the Premier Perspective database (Premier, Charlotte, NC). Patients were stratified by TXA use and records were assessed for complications of new onset seizures, strokes, pulmonary embolisms (PE) or deep vein thromboses (DVT) occurring during the perioperative period. Results: In this cohort of 2,633 pediatric patients undergoing posterior spinal fusions, most often to treat adolescent idiopathic scoliosis, 15% received TXA. Overall, adverse events were rare in this patient population. The incidence of seizure, stoke, PE, or DVT in the control group was 0.54% (95% CI, 0.31% to 0.94%) and not significantly different from the TXA group. There was no significant difference in the incidence of DVTs, and no incidences of stroke in either group. There were no new-onset seizures or PEs in patients who received TXA. Conclusions: The use of TXA was not associated with an increased risk of adverse events including seizure, stroke, PE, and DVT. Our findings support the safety of TXA use in pediatric patients undergoing spinal fusion surgery.
Preoperative Blood Management in Elderly Patients with Delayed Intertrochanteric Fracture Surgery as a Necessary Measure: A Review Data Collection
Authors: Cui Yu , Wang Zhimeng , Lu Yao , Huang Qiang , Zhang Congming , Sun Liang , Ran Cheng , Wang Qian , Ma Teng , Li Zhong , Zhang Kun , Xue Hanzhong 
Published: February 2022

Abstract
Research on preoperative blood management in the elderly with delayed intertrochanteric fractures surgery is scarce, especially in hematopoiesis and hemostasis. We aimed to assess the effectiveness of the optimized blood management program in elderly patients with delayed intertrochanteric fractures surgery. This retrospective study included 833 patients with intertrochanteric fractures after delayed surgery. According to the actual optimized blood management plan, they were divided into four groups: Group A was the control group; Group B received 1 g of IV TXA at admission; group C underwent sequential TXA treatment after admission until 1 d before surgery (1 g/d); group D received iron supplements (200 mg/d) in addition to the treatment administered to group C, with or without recombinant human erythropoietin (rHuEPO; 40,000 IU). The primary outcomes were preoperative hidden blood loss (HBL), preoperative allogeneic blood transfusion (ABT) rate, hemoglobin (Hb) change, and actual Hb drop. The Hb reduction, calculated HBL, and hospitalization duration in groups C and D were significantly lower than those in groups A and B. The preoperative ABT rates in groups C and D were significantly lower than those in groups A and B, but there was no statistical difference between groups C and D. In conclusion, this study suggested that the iron supplement (with or without rHuEPO) combined with sequential intravenous tranexamic acid (IV TXA) scheme did not show a better clinical effect than sequential IV TXA scheme in management of patients with delayed intertrochanteric fractures surgery. Therefore, before recommending iron supplements and rHuEPO in elderly patients, further evaluation is needed.
Stability Assessment for Selection of Elite Sugarcane Clones Across Multi-Environment Based on AMMI and GGE- Biplot Models
Authors: Mehareb Eid M , Osman M.A.M. , Attia A.E , Bekheet M.A. , Fouz Abo Elenen FM 
Published: February 2022

Abstract
Seven field experiments were conducted at three experiment stations representing major sugarcane producing regions in Egypt. Each experiment comprised a randomized complete block design with three replications. Fourteen elite breeding lines typical of those routinely generated in the three final selection stages of sugarcane breeding programs in Egypt, along with one check variety (GT54-9) were evaluated for cane and sugar yield in this study during the 2018/2019, 2019/2020 and 2020/2021 seasons. Stability parameters including cultivar stability rank and superiority index were determined. The data was also investigated using GGE-biplots, the additive main effects and multiplicative interaction model (AMMI), and the AMMI stability value (ASV). The genotype main effect was used to visualize the G x E interaction. The results of these trials are of significance in guiding the selection and recommendation of superior sugarcane varieties and more stable in sugarcane production zones. The clone G.2016-129 had a mean sugar yield and cultivar superiority index for sugar yield exceeding that of GT54-9, and hence was recommended for commercial planting. Because of local conditions in Egypt, an elite sugarcane variety would have high and stable yield and would adapt to a wide range of environments. In the present study, only one clone G.2016-129 fit that definition by producing higher and more stable sugar yield than the commercial variety GT 54-9.. At the side of multivariate analyses, the ASV (AMMI stability value) supports selection of stable varieties in the AMMI Method. Varieties with lowest ASV are stable. Therefore, the results of this study exposed that G.2016-95, F-150 and G.2016-129 with lowest ASV for cane yield by contrast, G.2009-11, G.2016-128, F-150 and G.2016-95 with lowest ASV for sugar yield, were stable clones for cane and sugar yields, respectively
Comprehensive comparison of treatments for controlling the large pine weevil (Hylobius abietis) in Central Europe
Authors: Galko Juraj , Lalík Michal , Rell Slavomír , Nikolov Christo , Barta Marek , Pittner Ján , Hyblerová Silvia , Zúbrik Milan , Kunca Andrej , Vakula Jozef , Gubka Andrej , Holuša Jaroslav 
Published: February 2022

Abstract
Adults of the large pine weevil (Hylobius abietis) cause serious damage to coniferous seedlings and are among the most important forest pests in Europe. Seedling protection by chemicals is gradually being restricted or banned for environmental reasons, and non-chemical alternatives are therefore needed. In this 3-year study, we compared the following five treatments for protecting Norway spruce seedlings against H. abietis in the Central European mountains where the weevil is especially abundant: alpha-cypermethrin sprays (the only chemical treatment); coating with sprayed glue (Vermifix); coating with C and F types (Norsk Wax); and physical protection with collars. The same block design was set up at a clear-cut site and at a nursery site to compare seedling mortality and wax quality under “wild conditions” with pests and under “ideal conditions” without pests. Repeated application of alpha-cypermethrin was the most effective and least expensive method to protect seedlings against H. abietis. Among the four non-chemical methods, repeated application of glue was the most effective. Because collars were moderately effective but not cost-effective, we do not recommend the use of collars. Wax was inexpensive and environmentally safe but protected seedlings for only 1 year; the newer F type of wax performed better than the C type of wax, and perhaps the F type can be improved. We found that seedlings at sites with high numbers of H. abietis require protection for at least 3 years. We conclude by providing an overview of all methods currently available for managing H. abietis in forests.
Atraumatic Restorative Treatment as public policy: a systematic review
Authors: Martins Fábio Carneiro , Pontes Laura Regina Antunes , Gonçalves Gabriela da Silva Martins , Gabriel Mariana , Raggio Daniela Prócida , Braga Mariana Minatel , Frias Antonio Carlos , Carrer Fernanda Campos de Almeida 
Published: February 2022

Abstract
Background: This systematic review aimed to identify, describe, and analyze the global context of Atraumatic Restorative Treatment (ART) as public policy. Methods: The inclusion criteria were: studies on public oral health policies, dental caries, or ART. The exclusion criteria were: clinical studies, specific interventions unrelated to the decision making of managers or policymakers, studies that report public oral health policies that do not use ART as a strategy for caries treatment. A literature search was conducted in PubMed, BVS, Epistemonikos, Health Systems Evidence, and Rx for change. There were no language restrictions. Data extraction was performed by two authors independently according to the stages and categories of a conceptual framework and organized in spreadsheets using Microsoft Excel 365. Of the 2253 eligible articles, 139 were duplicates, and 1680 were not included after reviewing the title and abstract. After assessing the full text, 414 articles were excluded. Results: 20 articles were included in the current review. Nineteen were conducted in nine countries: South Africa (n = 3), Bolivia (n = 1), Cambodia (n = 2), Egypt (n = 2), Mexico (n = 2), Tanzania (n = 4), East Timor (n = 1), Tunisia (n = 1), and Zimbabwe (n = 3), and one in the Americas. Regarding local contexts, the studies reported a high prevalence of dental caries and a lack of access to restorative procedures in health services as common problems. Policy development processes were similar in some aspects, such as the presence of governments, conceptual use of scientific evidence, and induction by the World Health Organization. Regarding the barriers identified in the implementation stage, the lack of supplies to carry out the procedures and induction of the work process by managers were mentioned. As for the facilitators, permanent education and professional practice were mentioned. Cohort studies have shown promising results, with a survival rate greater than 80% after one year of follow up. Conclusions: The findings of this systematic review indicate that the use of ART in public policies is a promising option for tackling common problems in several countries, however, its use is still in an early stage.
The relationship between ambulatory arterial stiffness index and left ventricular diastolic dysfunction in HFpEF: a prospective observational study
Authors: Liu Zhiqiang , Zhang Hanwen , Hu Weiwei , Wang Yu , Liu Jie , You Linna , Dong Qian , Chang Guanglei , Cheng Xiaocheng , Zhang Dongying 
Published: February 2022

Abstract
Background The relationship between ambulatory arterial stiffness index (AASI) and left ventricular diastolic dysfunction in patients with heart failure with preserved ejection fraction (HFpEF) is unknown. We aimed to investigate whether increased AASI was related to left ventricular diastolic dysfunction in patients with HFpEF. Methods We prospective enrolled consecutive patients with HFpEF in Chongqing, China. Twenty-four-hour ambulatory blood pressure monitoring (24h-ABPM) and echocardiography were performed in each patient. AASI was obtained through individual 24h-ABPM. The relationship between AASI and left ventricular diastolic function was analyzed.Results A total of 91 patients with HFpEF were included. The mean age was 68.7±13.9 years and 54 (59%) were women. The patients were divided into two groups according to the upper normal border of AASI (0.55). AASI > 0.55 group were more likely to be older, to have higher mean systolic blood pressure and worsen left ventricular diastolic function than AASI group ≤ 0.55. AASI was closely positive related to the diastolic function parameters, including mean E/e’ (r = 0.290, P = 0.005), septal E/e’ (r = 0.237, P = 0.024), lateral E/e’ (r = 0.295, P = 0.004) and E (r = 0.262, P = 0.012). After adjusting for conventional risk factors, AASI was still an independent risk factors of left ventricular diastolic dysfunction in patients with HFpEF (odds ratio: 3.261, 95%CI: 1.099-9.673, P=0.033). Conclusion Increased AASI was independent associated with left ventricular diastolic dysfunction in patients with HFpEF.
Effect of Hydrophobic Groups on Adsorption of Amino Acids to Solid Surfaces in Water
Authors: Fukushima Akinori , Hirano Masaya , Sato Ryuichi 
Published: February 2022

Abstract
We calculated the free energies of adsorption between a solid wall and various arginine derivatives in water using molecular dynamics simulations. We varied the hydrophobic group size of the amino acids in two ways and the hydrophilicity of the solid wall in five ways. The free energy of adsorption decreased by increasing the hydrophilicity of the solid wall, regardless of the size of the hydrophobic group. Amino acids with small hydrophobic groups adsorbed on the solid wall with the strongest hydrophilicity, but the free energy of the amino acids with large hydrophobic groups was relatively small. The free energy of adsorption in benzene solvent increased by increasing hydrophilicity of the solid wall, yet analogously to results in water solvent was independent of the size of the hydrophobic group. We attribute these differences in free energy to the effect of solvent molecules localized on the solid wall. Thus, these results may modulate peptide adsorption on a solid surface by the size of the peptide’s hydrophobic groups.
An Optimization and Formability Assessment Tool for Incremental Sheet Forming
Authors: Lew Maan Tarng , Kumar Dharmesh , Suwat Jirathearanat , Chaudhari Akshay , Zhang Yunfeng , Anantharajan Senthil Kumar 
Published: February 2022

Abstract
Incremental Sheet Forming (ISF) is a novel die-less forming process, which is suitable for small batch production. It has high forming flexibility and is able to form highly complex free form part geometry. However, the parts formed using the ISF process may have geometrical inaccuracies, pillow effect and part failure when the forming wall angle exceeds the limit. Hence, it is important to know the formability of a part ahead in order to plan the ISF process correctly. One method to know the formability is by finding the optimum forming orientation. In the current state of art, some studies were carried out to obtain the optimum forming orientation by using Stereolithography model (STL) on symmetrical parts. However, it is noticed that there is lack of investigations of the optimum forming orientation on non-symmetrical part. Hence, in this work, a new approach in finding the optimum forming orientation of non-symmetrical part is proposed by considering the formability of the part along two axes. To implement this new approach, a genetic-algorithm-like method is proposed and explained. The proposed algorithm is integrated with visual color map. The optimized forming orientation, local wall angle, and percentage reduction of sheet thickness are presented in the color map format to further assist the end user. Several experiments were conducted to test the proposed algorithm. From the experimental investigations, it can be concluded that the proposed algorithm helps the user to identify potential failure areas and, thus, reduce the failures by reorienting the part forming direction.
An M0 Macrophage-Related Prognostic Model for Hepatocellular Carcinoma
Authors: Zhang Yiya , Zou Ju , Chen Ruochan 
Published: February 2022

Abstract
Background
The role of M0 macrophages and their related genes in the prognosis of hepatocellular carcinoma (HCC) remains poorly characterized.
Methods
Multidimensional bioinformatic methods were used to constructed a risk score model using M0 macrophage-related genes (M0RGs).
Results
Infiltration of M0 macrophages was significantly higher in HCC tissues than in normal liver tissues (P = 2.299e-07). Further analysis revealed 35 M0RGs that were associated with HCC prognosis; two M0RGs (OLA1 and ATIC) were constructed and validated as a prognostic signature for overall survival of patients with HCC. Survival analysis revealed the positive relationship between the M0RG signature and unfavorable prognosis. Correlation analysis showed that this risk model had positive associations with clinicopathological characteristics, somatic gene mutations, immune cell infiltration, immune checkpoint inhibitor targets, and efficacy of common drugs.
Conclusions
The constructed M0RG-based risk model may be promising for the clinical prediction of prognoses and therapeutic responses in patients with HCC.
Risk factors associated with testing positive for brucellosis and occurrence of abortion in high-yielding Holstein heifers
Authors: Luna Marcos , Encina Juan , Álvarez Perpetuo , García José Eduardo , Macías-Cruz Ulises , Avendaño-Reyes Leonel , Mellado Miguel 
Published: February 2022

Abstract
This retrospective study aimed to estimate the seroprevalence of bovine brucellosis (bBR) in high-yielding Holstein heifers and identify risk factors associated with seropositivity to this disease. An additional aim was to assess the heifer-related risk factors for abortion. This study was carried out on a commercial dairy farm in northern Mexico (25° N) using 3848 heifers from 2018 to 2021. The seroprevalence of bBR was 30% (95% CI = 29–32%) for lactating heifers (card test). Multiple logistic regression models indicated that heifers with > 680 kg at calving had half the risk of being positive to bBR than heifers with < 680 kg at calving (22.7 vs. 36.1%). Heifers suffering from diarrhea during the growing period were 1.3 times more likely to be seropositive to bBR than heifers not diagnosed with this disease (34.1 vs. 29.4%; P < 0.01). The risk of being seropositive to bBR increased in heifers suffering from retained placenta compared with heifers not suffering from this reproductive disorder (OR = 2.46; 47.5 vs. 26.3%). Heifers vaccinated with two doses of commercial vaccines against brucellosis were associated (P < 0.01) with 2.2 times higher odds of being seropositive to bBR than heifers vaccinated only once. Heifers seropositive to bBR were 3.1 times more likely to abort than heifers seronegative to this disease (38.5 vs. 16.2%; P < 0.01). Heifers with body condition score (BCS) ≥ 3.5 at calving (OR = 0.3) had a protective role for seropositive to bBR. The likelihood of having an abortion was 3.1 times higher in heifers diagnosed with retained placenta than in those not having this reproductive disorder. It was concluded that brucellosis control programs should focus on age at first calving, retained placenta, and the number of brucellosis strain RB51 vaccinations applied to heifers. Increasing BCS was advantageous to achieve lower abortion rates.
WITHDRAWN: HSPA8 is a New Biomarker of Triple Negative Breast Cancer Associated with Prognosis and Immune Infiltration
Authors: bicheng ying , wenting xu , yan nie , yongtao li 
Published: February 2022

Abstract
Objective
Triple negative breast cancer (TNBC) is a malignant tumor that endangers the health and lives of women all over the world in the 21st century. Heat shock protein member 8 (HSPA8/HSC70) is the chaperone gene of the heat shock protein family. It is involved in many cellular functions.For example, it promotes the circulation between ATP and ADP, participates in protein folding, and can change the vitality of the cell and inhibit its growth. HSPA8 overexpression in several human cancers reportedly leads to its malignant transformation. Nonetheless, the HSPA8 mRNA abnormal expression in TNBC and its diagnostic and prognostic significance remains to be elucidated.
Methods
TCGA, GEO, ONCOMINE,TIMER2.0, UALCAN, HPA, STRING and Kaplan-Meier plotter were conducted for bioinformatics analysis. HSPA8 protein expression was evaluated by Immunohistochemical method in TNBC tissues. Western blotting experiments were carried out to verify the results. Then the clinicopathological characteristics of patients with TNBC were analyzed by R software and Cox regression analysis. On this basis, a nomogram is constructed to estimate the 5-year overall survival. The prognostic Nomogram performance was calibrated and evaluated by calibration curve and receiver operating characteristic (ROC) curve .
Results
In this study, we discovered remarkably upregulated transcription of HSPA8 in breast cancer (BC) samples and TNBC samples relative to normal breast samples through bioinformatic analysis, which was further verified in clinical tissue samples and in experiments. Moreover, the transcriptional level of HSPA8 in BC samples and TNBC samples was positively associated with clinical parameters such as clinical tumor stage. Cox regression analysis revealed that the expression of HSPA8 in TNBC had significant clinical prognostic value. The nomogram and ROC analysis results demonstrated the strong predictive ability of HSPA8 in TNBC. KEGG and GO researches indicated that HSPA8 was mainly involved in partner-mediated autophagy, mRNA catabolism, neutrophil activation, immune response, protein targeting, RNA splicing, RNA catabolism and other biological processes.Immune infiltration analysis indicated that HSPA8 was significantly associated with immune cell subsets.
Conclusions
Our study findings demonstrate the potential diagnostic and prognostic significance of HSPA8 expression in TNBC, and elucidate the potential molecular mechanism of promoting the occurrence and development of TNBC. These results may provide new opportunities and research approaches for targeted therapies in TNBC.
Real-Time Laser Ultrasonic Monitoring of Laser-Induced Thermal Processes
Authors: Morales Rosa E. , Harke Kathryn J. , Tringe Joseph W. , Stobbe David M. , Murray Todd W. 
Published: February 2022

Abstract
Intra- and inter-layer integrity of components fabricated with advanced manufacturing techniques, such as laser powder bed fusion, is dependent upon rapid heating, melting, and solidification processes. There is a need for new techniques to provide in situ feedback of these processes. Here a laser-based ultrasonic technique to probe thermal effects induced by a high-power continuous wave laser in titanium samples is described. Numerical simulations were performed to show that, for a spatially uniform heating beam, laser-induced surface acoustic waves are strongly influenced by surface heating conditions, are dispersive in the case of rapid heating, and that an abrupt velocity reduction happens upon the onset of surface melting. Furthermore, laser-based ultrasound experimental results which monitor the transient change of surface wave travel time associated with high power laser surface heating are provided. A pulsed laser is used to generate high frequency surface acoustic waves that propagate through the laser-heated region and are detected using a photorefractive crystal-based interferometer. Qualitative agreement is observed between theory and experiment with both showing a rapid delay in the surface wave velocity at the onset of illumination and further decrease in surface wave velocity associated with melting. It is demonstrated that changes in the surface wave velocity can be used to track local heating and detect the onset of surface melting in real time.