bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eximente de Responsabilidad de los Accionistas por Obligaciones Laborales en la Sociedad por Acciones Simplificada: ¿Violación al principio de intangibilidad de los Derechos Laborales?
Authors: Salvador José Alejandro 
Published: September 2022

Este trabajo tiene como finalidad discutir acerca del conflicto de normas suscitado entre la Ley de Compañías y el Código de Trabajo respecto de la responsabilidad de los accionistas por las obligaciones laborales. Por una parte, La ley de Compañías, con la entrada en vigencia de la sociedad por acciones simplificada en la Ley de Compañías, su implementación supone que los accionistas no serán responsables por dichas obligaciones. Por otro lado, el Código de Trabajo indica que los socios responderán solidariamente por las deudas de la sociedad cuando el trabajo se realice para dos o más personas en calidad de socios. Por lo mismo, se discutirá qué norma prima dentro del presente conflicto de normas. Una vez determinada la primacía de la Ley de Compañías, se determinará por qué esto no representa una violación a los principios constitucionales de intangibilidad e irrenunciabilidad de los derechos laborales, sino más bien una excepcionalidad que no pretende desconocer en lo absoluto la responsabilidad de los accionistas, sino más bien brindar seguridad jurídica a los nuevos emprendimientos y garantizar deber del Estado de asegurar un desenvolvimiento eficiente de la actividad económica e inversión, sin que esto signifique menoscabar derechos laborales.
Efek Diet Ketogenik Pada Diabetes Mellitus Tipe 2: Scoping Review
Authors: Putri Melin Novidinisa Herada , Dewi Mutia Amalina , Handayani Dian 
Published: September 2022

Latar Belakang : Diabetes Mellitus (DM) merupakan penyakit metabolik yang sampai saat ini masih menjadi masalah terbesar di dunia dan Indonesia. Penatalaksanaan diet dianggap sebagai komponen penting dalam manajemen diabetes. Diet ketogenik (DK) dilaporkan memiliki efektivitas yang baik dalam manajemen terapi pasien DM Tipe 2 dengan memperbaiki parameter glukosa darah, profil lipid maupun antropometri, namun tetap dibutuhkan pemahaman yang tepat terkait praktik pemberiannya agar terapi yang diberikan efektif untuk perbaikan parameter DM.Tujuan: Artikel ini bertujuan untuk mengkaji hasil penelitian terdahulu terkait efektivitas diet ketogenik terhadap perbaikan parameter DM Tipe 2 yaitu glukosa darah, profil lipid dan antropometri.Metode: Metode yang digunakan dalam scoping review ini adalah Prism-ScR. Artikel pada kajian ini diperoleh dari database PubMed, Proquest dan MDPI. Kemudian, dilakukan seleksi artikel menggunakan metode PICOS Framework dan didapatkan artikel akhir untuk dilakukan kajian mendalam.Diskusi: Beberapa hasil penelitian menunjukkan diet ketogenik dapat memberikan dampak positif terhadap perbaikan parameter pada pasien Diabetes Mellitus Tipe 2 (profil glukosa, profil lipid dan indeks antropometri). Pemberian karbohidrat sebanyak 20-50 g/hari atau sekitar 5-10%, lemak 70-75% dan protein 20-15% dari total kebutuhan energi harian dapat menciptakan keadaan ketosis nutrisi. Pengaruh DK pada penderita DMT2 juga sangat bergantung pada proporsi dan jenis makanan yang dikonsumsi, lama penerapan serta kepatuhan terhadap diet yang dijalankan. Komposisi diet keto yang tidak tepat dan tidak sesuai dengan kondisi Kesehatan pasien akan memunculkan efek samping yang membahayakan kondisi pasien.Kesimpulan: Hasil review menunjukkan diet ketogenik dinilai ada yang memberikan manfaat positif dalam perbaikan parameter DMT2 yaitu profil glukosa, profil lipid dan indeks antropometri namun ada juga yang tidak memberikan manfaat positif. Implementasi diet ketogenik harus dibawah pengawasan tenaga medis /dokter dan nutrisionis dan / dietisien agar diperoleh bahan pilihan bahan makanan yang baik dan sesuai dengan kondisi individual pasien DMT2. Sangat dianjurkan untuk melakukan konsultasi terkait Kesehatan dan perencanaan diet sebelum mengaplikasikan diet tersebut guna menghindari terjadinya efek samping serta komplikasi pada penerapannya.
Hubungan Kadar Antioksidan Superoxide Dismutase (SOD) dengan Abnormalitas dalam Tingkat Pengencer dan Lama Simpan Semen Mentog di Suhu Dingin
Authors: Fitriani  
Published: September 2022

Tujuan penelitian ini adalah mengetahui pengaruh penambahan kuning telur sebagai cryoprotectant dalam tingkat pengencer dan lama simpan pada semen mentog yang disimpan pada suhu dingin.Mentog yang digunakan dalam penelitian ini adalah 4 ekor ternak entog jantan berumur sekitar 1,5 – 2 tahun dengan berat badan 3 – 3,5 kg. Penampungan semen mentog dilakukan pagi dengan frekuensi penampungan 2x/minggu, Metode penelitian yang digunakan metode eksperimental dengan Split Plot pola petak terbagi. Faktor pertama sebagai Petak Utama adalah tingkat pengencer yaitu tanpa pengencer (A0); 5 X(A1);10X(A2) dan 15X (A3),faktor kedua sebagai Anak Petak adalah lama simpan 0(B0); 60 (B1); 120 (B2) dan 180 menit yang disimpan pada suhu dingin 4ºC.Tiga kelompok kandang mentog sebagai ulanganyang diambil semennya. Hasil yang diperoleh melalui analisis ragam menunjukkan terdapat pengaruhtetapi tidak nyata baik SOD maupun abnormalitas(P<0.05). Kesimpulan adalahtingkat pengenceran dan lama simpan beda berpengaruh tetapi tidak nyata (P < 0,05). Kuning telur dalam pengenceransemen mentog sebagai cryoprotectant dapat mempertahankan semen mentog.
Pelatihan Pembuatan Cairan Serbaguna Eco-Enzyme dari Sampah Organik dan Cara Pemanfaatannya di Desa Gondangmanis, Bae, Kudus
Authors: Yuliani Farida , Kristiowati Diana , Hermyantono Chris 
Published: September 2022

<p><strong>Training on Making Eco-Enzyme Multipurpose Liquids from OrganicWastes and How to Use in Gondangmanis Village, Bae, Kudus. </strong>Eco-Enzyme (EE) is a multifunctional liquid produced from anaerobic fermentation of organic waste, especially from fresh fruit and vegetable wastes. Until now, most Indonesian citizens have not known about this enzyme, including the partner, residents of Gondangmanis Village, Bae District, Kudus Regency. This training aims to enable the partners to produce EE from organic wastes at the household level and its application. The direct benefit of this activity is to add value to household waste. The indirect benefit is to increase the volume of recyclable wastes towards zero waste. The used method consisted of lectures, practices of EE production, storage, and application. The EE production practice used a plastic drum with a capacity of 120 liter filled with 90 liter of water, 27 kg of organic wastes, and 9 kg of molasses. The result showed that total EE produced was 73 liter, smells good with light brown, and at a pH of 3.0. The partner used the EE for household cleaning, air purification, and floodwater purification. There is a percentage increase in participants' understanding of 90% who initially did not know EE to be able to make and apply it. Using organic waste for EE production can reduce as much as 50% of the amount of organic waste.</p>
Upscaling Shear Strength of Heterogeneous Oil Sands with Interbedded Shales Using Artificial Neural Network
Authors: Zhang Bo , Ma Zhiwei , Zheng Dongming , Chalaturnyk Rick J. , Boisvert Jeff 
Published: September 2022

SummaryUnderstanding the shear strength of caprock shale and oil sands is important in risk assessment of slope stability in open-pit mining, caprock integrity of in-situ thermal recovery, and optimization of bitumen production from oil sands. A robust and efficient upscaling technique is essential to model the impact of heterogeneity on the deformation and failure of oil sands and caprock shale. Although conventional analytical and numerical upscaling techniques are available, many of these methods consider oversimplified assumptions and have high computational costs, especially when considering the impact of spatially correlated interbedded shales on the shear strength. A machine learning enhanced upscaling (MLEU) technique that leverages the accuracy of local numerical upscaling and the efficiency of artificial neural network (ANN) is proposed here. MLEU uses a fast and accurate ANN proxy model to predict the anisotropic shear strength of heterogeneous oil sands with interbedded shales. The R2 values of the trained ANN models exceed 0.94 for estimating shear strengths in horizontal and vertical directions. The deviation of upscaled shear strength from numerical upscaled results is improved by 12–76% compared with multivariate regression methods like response surface methodology (RSM) and polynomial chaos expansion (PCE). In terms of computational efficiency, the proposed MLEU method can save computational effort by two orders of magnitude compared with numerical upscaling. MLEU provides a reasonable estimate of anisotropic shear strength while considering uncertainties caused by different distributions of shale beddings. With the increasing demand for regional scale modeling of geomechanical problems, the proposed MLEU technique can be extended to other geological settings, where weak beddings play a significant role and the impact of heterogeneity on shear strength is important.
Can weed composition and diversity support chickpea yield? A case study on dryland fields from western Iran
Authors: Sohrabi Naser , Bagheri Alireza , Nosratti Iraj , Mondani Farzad 
Published: September 2022

Abstract
To evaluate the impacts of weed communities on chickpea yield (Cicer arietinum L.), an on-farm survey was conducted with a sampling from 85 dryland chickpea fields in a rural district, western Iran. The results showed that chickpea yield tended to decrease with increasing weed density and canopy cover as indicated by a polynomial response. Increasing weed density from 0 to 50 plant m-2 reduced the chickpea yield by 36.73% at the four to seven-leaf stage of chickpea. In addition, increases canopy cover from 0 to 55% caused chickpea yield loses by 41.70 g m-2 at the early podding stage of chickpea. Weed diversity and evenness had a positive effect on chickpea yield. Wild safflower (Carthamus oxyacantha M. Bieb.) and chicory (Cichorium intybus L.) were the most predominant weeds with a significant negative correlation with chickpea yield, weed evenness and diversity. Some weeds, such as licorice (Glycyrrhiza glabra L.) had a negative correlation with chicory and wild safflower and a positive correlation with weed diversity and evenness. In addition, there was a positive relationship between density and canopy cover of licorice and chickpea yield, weed diversity and evenness.
Establishment of in vitro shoot tips regeneration system of foxtail millet and obtainment of transgenic plants of SiSERK1
Authors: Guofan Wu , Nongfu Tian , Wenbo Li , Wangze Wu , Sheng Zheng , Ning Yang 
Published: September 2022

Abstract

Foxtail millet (Setaria italica) would be suitable as a model plant of C4 plants given its small genome (about 470 MB) and diploid self-pollination. However, the study of foxtail millet faces the problem of low efficiency of explant regeneration and genetic transformation. In this study, a new genetic transformation system of Yugu1 foxtail millet is established with in vitro shoot tips as the explant, and, the concentrations of 6-BA and kanamycin are optimized. It is found 0.5 mg L-1 6-BA and 25 mg L-1 kanamycin are the most suitable in terms of the differentiation rate of shoot tips and survival rate of differentiated seedlings. In addition, 12 transgenic foxtail millets of SiSERK1 are identified by resistance screening and PCR. The insertion site of one line of the transgenic plants chosen at random is further identified. The results of qRT-PCR show that the expression of SiSERK1 gene in transgenic plants is significantly higher than that in wild-type plants. A new method of generation of material for further study of SiSERKs is provided for foxtail millet genetics and breeding.
DeDoc2 identifies and characterizes the hierarchy and dynamics of chromatin TAD-like domains in the single cells
Authors: zhang Zhihua , Li Angsheng , Zeng Guangjie , Wang Haoyu , Li Xiao 
Published: September 2022

Abstract
Topologically associating domains (TAD) are functional chromatin units with hierarchical structure. However, the existence, prevalence and dynamics of such hierarchy in single cells remain unexplored. Here, we report a new generation TAD-like domain (TLD) detection algorithm, named deDoc2, to decode the hierarchy of TLDs in single cells. With dynamic programming, deDoc2 seeks genome partitions with global minimal structure entropy for both whole and local contact matrix. Compared to state-of-the-art tools, deDoc2 can uniquely identify the hierarchy of TLDs in single cells, in addition to outperforming its competitors. By applying deDoc2, we showed that the hierarchy of TLDs in single cells is highly dynamic during cell cycle, as well as among human brain cortex cells, and that it is associated with cellular identity and functions. Thus, our results demonstrated the abundance of information potentially encoded by TLD hierarchy for functional regulation. The deDoc2 can be freely accessed at https://github.com/zengguangjie/deDoc2.
Exploration of the role of Mesencephalic astrocyte-derived neurotrophic factor in septic acute kidney injury
Authors: chen Saifeng , Guo Dongfeng , Hao Xuewei , Yuan Xiaoyan , Chen Guo , Liu Guorong , Xu Lei , Chen Yajing 
Published: September 2022

Abstract
Objective
The Mesencephalic astrocyte-derived neurotrophic factor whether it has a protective effect on sepsis renal injury.
Methods
Mice were randomly divided into Control group, Control + MANF group, SAKI group, and SAKI + MANF group (n = 24). SAKI model mice were constructed by intraperitoneal injection of 10 mg/kg LPS to SAKI group and SAKI + MANF group mice. The WESTERN BLOT method and ELISA method were used to determine the change of MANF content in mice with septic kidney injury. Then the renal function and inflammatory factors of SAKI model mice were measured, and the relationship between MANF content and renal function and inflammatory factors were observed. Subsequently, we injected 200µg/Kg MANF into the abdominal cavity of mice in the Control + MANF group and SAKI + MANF group. Measure the change of MANF content in mice and its relationship with renal function and inflammatory factors. Finally, the kidneys of the four groups of mice were observed by preparing pathological sections of kidney tissues.
Results
In the early stage of sepsis renal injury, the content of MANF increased rapidly, but with the progress of the disease, the content of MANF decreased, the renal function of mice decreased, An obvious abnormality was found in all indexes. After recombinant human Mesencephalic astrocyte-derived neurotrophic factor was given to septic renal injury mice, the renal function was restored. Pathological sections showed that the renal tissue of normal + MANF mice was similar to that of normal mice, and there was no significant change. The renal tissue of septic renal injury mice was significantly damaged.
Conclusion
Mesencephalic astrocyte-derived neurotrophic factor has a certain protective effect on septic renal injury. Exogenous supplement of MANF can effectively alleviate the degree of renal injury after septic renal injury.
Spatiotemporal microplastic occurrence study of Harike wetland, A Ramsar wetland of India
Authors: Manzoor Shaista , Singh Rahul 
Published: September 2022

Abstract
Ramsar wetlands are one of the least investigated areas for microplastic contamination. Harike wetland is located downstream of the confluence of the Beas and Sutlej rivers. Rivers are nature's drainage systems, which collect waste from everywhere and move ahead. On the same note, the Harike wetland, which is the largest wetland in North India and is a great home for migratory birds and aquatic animals, and the water of its canal that supplies water to the semiarid part of India's largest state, microplastics in the water were analyzed. Apart from seasonal variation, the fish gut of C. carpio caught from the fishing site of the canal has also been analysed. Between sites 1 and 2, no significant difference was found in the quantity of microplastics, but in season variation, winter showed a higher significant level than summer and the rainy season. The wetland and canal were dominated by two types of plastics: HDPE and nylon. The conformational test, along with FTIR and GC-MS, was also performed. From the gut of C. carpio, microplastics of less than 5mm in size were also recovered. The percentage of recovery was 7% of the total fish analysed. This percentage may be less, but it is not ignorable. Indeed, the amount of poorly managed plastic garbage generated by people living around or illegal outskirts garbage dumping near rivers and tributaries is a potential source of aquatic debris.
Covid-19 vaccination hesitancy in Mexico City among healthy adults and adults with chronic diseases
Authors: Gonzalez-Block Miguel , Calderón Emilio Gutiérrez , Sarti Elsa 
Published: September 2022

Abstract
Background. Monitoring of SARS-COV-2 vaccine hesitancy is important for epidemic control. We measured vaccine hesitancy among healthy adults and adults with chronic diseases after they had been offered the first dose of the vaccine in Mexico City.
Methods. An observational cross-sectional study was undertaken among 185 healthy adults and 175 adults living with chronic diseases. Differences in means of variables for confidence, complacency, and convenience were analyzed. Aggregate indicators were constructed and their association to socioeconomic and demographic conditions and to vaccination acceptance were analyzed using multivariate analysis of variance and multivariate logistic analysis.
Results. Up to 16.8% of healthy adults and 10.3% of sick adults report not having received the SARS-COV-2 vaccine. Healthy adults are more complacent about COVID-19 risks than adults with chronic diseases, while no differences were reported across the two groups regarding other hesitancy aggregate indicators. Among adults with chronic diseases, those with more education and enrolled with a social insurance institution are less complacent of COVID-19, while education is positively associated to convenience across both groups. Less complacency with COVID-19 and more confidence on the vaccine are associated to higher vaccine acceptance across both groups. Among adults living with chronic diseases the odds ratios of vaccine acceptance are higher for less complacency (OR=2.4, p=0.007) than for confidence (OR=2.0, p=0.001). Odds ratios of vaccine acceptance in these two hesitancy indicators are similar among healthy adults (OR=3.3, p=<0.005), and higher than for adults with comorbidities.
Conclusions. Confidence in the vaccine and complacency regarding COVID-19 risks play an important role for vaccine acceptance in Mexico City, particularly among healthy adults. The perception of risk regarding COVID-19 is more important than confidence in vaccine safety and effectiveness. Promotion of COVID-19 vaccines needs to focus on decreasing complacency with COVID-19 and increasing vaccine confidence, particularly among healthy adults.
Knowledge domain and hotspot trends in coal and gas outburst: a scientometric review based on CiteSpace analysis
Authors: Xu Chao , Yang Tong , Wang Kai , Guo Lin , Li Xiaomin 
Published: September 2022

Abstract
Coal and gas outburst is one of the main dynamic disasters in coal mine production. When a coal and gas outburst occurs, a large amount of coal and gas are thrown into the mining space, causing casualties and equipment damage, and even inducing secondary disasters such as gas explosions and coal dust explosions. Therefore, it is essential to carry out relevant research on coal and gas outburst to prevent the occurrence and development of accidents. In order to deeply understand the overall research progress in the field of coal and gas outburst, the Web of Science (WOS) database is used as the sample source, and the bibliometric analysis of the literature in the field of coal and gas outburst from 2000 to 2021 is carried out by CiteSpace software. The knowledge maps of the publication quantity, country, institution, and keyword cluster are drawn. The results show that the time distribution has gone through three stages of germination period, development period, and growth period. Especially during 2010–2021, the publication quantity increased exponentially, which opened the golden age of rapid development in the field of coal and gas outburst. In terms of the cooperation network, China, Australia, and USA are the main core research countries, while China University of Mining and Technology, Chongqing University, and Henan Polytechnic University are the main core research institutions, and the main core journals are IGCG, IGRMM, and Fuel. By drawing the knowledge map of keywords timeline, the evolution law of keywords in the field of coal and gas outburst with time is obtained; Taking keywords as the object, cluster labels with gas outburst, gas extraction, gas control, and pore structure as the core are presented; By extracting and analyzing the top 10 keywords of burst strength, keywords such as stress, disaster, and desorption have gradually become the development trend of hot spots and have been widely concerned by researchers. On this basis, from a new perspective, this paper outlines the "scientific research landscape map" in the field of coal and gas outburst, in order to provide a scientific reference for coal and gas outburst research.
Analysis of CAFs‑related Genes Identifies COL11A1 Associated with Lung Adenocarcinoma Diagnosis and Prognosis
Authors: haosheng zheng , Qin Xianyu , Zheng Yuzhen , Yang Xingping , Tan Jian , Cai Weijie , He Shiyun , Liao Hongying 
Published: September 2022

Abstract
Background
Difficulties in the treatment of lung adenocarcinoma(LUAD) are due to lack of understanding of relevant molecular mechanisms and limited potential therapeutic options. Cancer-related fibroblasts(CAFs) play an important role in the occurrence and development of cancers. Therefore, this study aimed to identify a promising molecular target associated with CAFs for the diagnosis and prognosis of LUAD.
Methods
The Cancer Genome Atlas (TCGA) LUAD dataset was used to screen out the hub genes by EPIC algorithm and Weighted Gene Co-expression Network Analysis (WGCNA). GEPIA database, Kaplan-Meier Plotter database, GSE72094, GSE75037, and GSE32863 were used to verify the differential expression and survival of hub genes. Immunohistochemistry (IHC) was used to assess the expression of COL11A1 in LUAD and adjacent normal tissues. GO/KEGG functional analyses and single-cell TISCH database were used to elucidate the underlying mechanisms of COL11A1.
Results
Based on the TCGA LUAD dataset, 13 hub genes associated with CAFs were screened out by the EPIC algorithm and WGCNA. These were ADAM12, ADAMTS12, COL11A1, COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, ITGA11, LRRC15, POSTN, THBS2, THY1. Using the GEPIA database, Kaplan-Meier Plotter database, GSE72094, GSE75037, and GSE32863, we confirmed that COL11A1 was overexpression in LUAD tumor tissues and high expression of COL11A1 had a poor prognosis. Using IHC experiment data, we confirmed that the expression of COL11A1 was significantly higher in LUAD (P < 0.001). We found that COL11A1 had a mutation frequency of 18% and COL11A1 promoter hypermethylation in LUAD (P < 0.05). Using GO/KEGG analyses, we found that COL11A1 was mainly related to the biological activities of the extracellular matrix in LUAD. Finally, in the TISCH database, we found that the expression of COL11A1 was mainly secreted by CAFs in the TME rather than from LUAD cells.
Conclusion
COL11A1 may be expressed and secreted by CAFs in the TME and affect the biological behavior of proliferation, invasion, and metastasis of LUAD cells. COL11A1 may serve as a potential diagnostic and prognosis biomarker for LUAD.