bluuebunny/crossref_metadata_2025_split huggingface dataset:
No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials
Authors: Du Puy Robert S , Poortvliet Rosalinde K E , Mooijaart Simon P , Stott David J , Quinn Terry , Sattar Naveed , Westendorp Rudi G J , Kearney Patricia M , McCarthy Vera J C , Byrne Stephen , Rodondi Nicolas , Baretella Oliver , Collet Tinh-Hai , van Heemst Diana , Dekkers Olaf M , Jukema J Wouter , Smit Johannes W A , Gussekloo Jacobijn , den Elzen Wendy P J 
Published: February 2022

Abstract

Context
Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing prevalence with advancing age.

Objective
The aim of this study was to assess whether levothyroxine treatment leads to a rise in hemoglobin levels in older persons with subclinical hypothyroidism.

Methods
This preplanned combined analysis of 2 randomized controlled trials included community-dwelling persons aged 65 years and older with subclinical hypothyroidism who were randomly assigned to levothyroxine or placebo treatment. The levothyroxine dose was periodically titrated aiming at thyroid stimulating hormone (TSH) level within the reference range, with mock titrations in the placebo group. The main outcome measure was the change in hemoglobin level after 12 months.

Results
Analyses included 669 participants (placebo n = 337, levothyroxine n = 332) with a median age of 75 years (range, 65-97) and mean baseline hemoglobin of 13.8 ± 1.3 g/dL. Although levothyroxine treatment resulted in a reduction in TSH from baseline after 12 months of follow-up compared with placebo, the change in hemoglobin level was not different between the levothyroxine and the placebo groups (−0.03 g/dL [95% CI, −0.16 to 0.11]). Similar results were found in stratified analyses including sex, age, or TSH levels. No difference in change of hemoglobin levels after 12 months was identified in 69 participants with anemia at baseline (−0.33 g/dL [95% CI, −0.87 to 0.21]).

Conclusion
In persons aged 65 years and older with subclinical hypothyroidism, treatment with levothyroxine does not lead to a rise in hemoglobin levels, regardless of the presence of anemia.
Impact of Woven EndoBridge Shape Modification on Aneurysm Recanalization at Short-Term Follow-up Digital Subtraction Angiography
Authors: Nawka Marie Teresa , Fiehler Jens , Bester Maxim , Broocks Gabriel 
Published: February 2022

BACKGROUND:
Woven EndoBridge (WEB) shape modification (WSM) is a frequently observed phenomenon after aneurysm embolization.

OBJECTIVE:
To test our hypothesis that WSM is associated with worse aneurysm occlusion on short-term angiographic follow-up images.

METHODS:
Patients with short-term follow-up digital subtraction angiography (DSA) available were included. Baseline patient characteristics, aneurysm morphometrics, and WEB dimensions (“conventional” parameters) and height and width WSM (“WSM” parameters) in the initial and the follow-up examination were analyzed. For ordinal regression analyses, aneurysm occlusion was graded according to the Bicêtre Occlusion Scale Score (BOSS; grades 0, 0′, 1, 2, 3, and 1 + 3). Receiver operating characteristic curve analysis was used to distinguish adequately (BOSS 0, 0′, and 1) from incompletely (BOSS 2, 3, and 1 + 3) occluded aneurysms.

RESULTS:
We included 93 patients with 96 aneurysms. Adequate occlusion was observed in 72 cases (75.0%). In univariate ordinal regression analysis, width WSM in anteroposterior DSA (odds ratio = 0.96, 95% CI: 0.94-0.99, P = .010) and in lateral DSA (odds ratio = 0.98, 95% CI: 0.97-0.99, P = .049) were significantly associated with the BOSS after 6 months. In multivariate regression analysis, WSM was not independently associated with aneurysm occlusion. Based on receiver operating characteristic curve analysis, the area under the curve (AUC) of the “conventional” model (AUC = 0.83, 95% CI 0.74-0.90) was higher than the AUC of the “WSM” model (WSM; AUC = 0.70, 95% CI 0.60-0.79).

CONCLUSION:
WSM was not independently associated with angiographic aneurysm occlusion status after 6 months. However, the “conventional” parameters including sex, rupture state, WEB type, WEB width, aneurysm width, height, and volume were associated with partial aneurysm recanalization in WEB-treated patients at the short-term follow-up.
Metabolic scaling of fire ants (Solenopsis invicta) engaged in collective behaviors
Authors: Ko Hungtang , Komilian Keyana , Waters James S. , Hu David L. 
Published: February 2022

ABSTRACT
During flash floods, fire ants (Solenopsis invicta Buren) link their bodies together to build rafts to stay afloat, and towers to anchor onto floating vegetation. Can such challenging conditions facilitate synchronization and coordination, resulting in energy savings per capita? To understand how stress affects metabolic rate, we used constant-volume respirometry to measure the metabolism of fire ant workers. Group metabolic rates were measured in a series of conditions: at normal state, at three elevated temperatures, during rafting, and during tower-building. We hypothesized that the metabolic rate of ants at various temperatures would scale isometrically (proportionally with the group mass). Indeed, we found metabolic rates scaled isometrically under all temperature conditions, giving evidence that groups of ants differ from entire colonies, which scale allometrically. We then hypothesized that the metabolism of ants engaged in rafting and tower-building would scale allometrically. We found partial evidence for this hypothesis: ants rafting for short times had allometric metabolic rates, but this effect vanished after 30 min. Rafting for long times and tower-building both scaled isometrically. Tower-building consumed the same energy per capita as ants in their normal state. Rafting ants consumed almost 43% more energy than ants in their normal state, with smaller rafts consuming more energy per capita. Together, our results suggest that stressful conditions requiring coordination can influence metabolic demand.
This article has an associated First Person interview with the first author of the paper.
International evaluation of current practices in cognitive assessment for motor neurone disease
Authors: Gray Debbie , Abrahams Sharon 
Published: February 2022

Background: Motor Neurone Disease (MND) is a rapidly progressive neurodegenerative disease, with up to 50% suffering from cognitive and/or behaviour changes. Aims: Evaluate current practices in the cognitive assessment of MND patients internationally. Methods: An online survey explored the use of cognitive assessments in MND clinics. Findings: 80/195 clinicians responded. The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) was the most popular method for evaluating cognition and 72% agreed that patients screened for cognitive change have better clinical care. Thematic analysis of open-ended responses indicated that cognitive assessments help to: identify and validate changes in cognition and behaviour, aid understanding of the clinical impact of the disease, inform and direct clinical care, and infer patients' decision-making abilities. However, a number of factors affected the implementation and administration of cognitive assessments in clinics. Conclusions: Cognitive assessments have been implemented in MND clinics internationally and have a positive impact on clinical practice.
Acquired brain injury nurse-led clinic: roll out, review and referral
Authors: O'Rourke Ciara 
Published: February 2022

Aim: This paper documents the introduction of a nurse-led outpatient clinic for patients post acquired brain injury (ABI). Nurse-led clinics in primary care settings have been widely acclaimed as a positive step towards improving access to investigations and specialist services, and offering a solution towards limited clinician resources. Method: A retrospective analysis was undertaken to review the ABI nurse-led clinic service over a 12-month period. This analysis reviewed how the clinic has impacted the hospital in terms of hours saved by the neurosurgical consultant clinic by the patient attending the nurse-led clinic. This paper also looks at how the clinic benefits the patient by timely access to the ABI clinical nurse specialist along with referrals and review by community-based rehab services, Headway Ireland and ABI Ireland. Findings: Through the review of the ABI clinic over a 12-month period, 47 hours were saved from the consultant led clinics. It was also found that 30% of patients reviewed in the ABI clinic were now in an appropriate ABI community support service. Conclusion: The audit shows that the ABI nurse-led clinic benefits the patient is terms of timely review and follow-up after traumatic brain injury (TBI). The patient also has early access to specialist TBI follow-on services, which enhances recovery and overall quality of care. The nurse-led clinic also benefits the organisation by reviewing and following up on patients who would have previously have been reviewed at the consultant-led clinics, therefore, reducing waiting times.
Effect of a physical and rehabilitation medicine doctor in a neurology department on the length of hospital stay for patients recovering from stroke
Authors: Khutorniuk Tamara , Sokolsky Vadim , Zilberman Steven , Lutsky Lena , Friedman Alan , Ifergan Gal , Treger Iuly 
Published: February 2022

Background/Aims Although in Israel a physical and rehabilitation medicine doctor is not an integral part of neurology department team, their attendance can have a positive effect on the management of patients recovering from stroke and their optimal transfer to rehabilitation setting. The aim of this study was to investigate if the presence of a physical and rehabilitation medicine doctor in a neurology department can influence the length of stay for patients recovering from stroke. Methods A retrospective comparative electronic data analysis of periods with and without a physical and rehabilitation medicine doctor was undertaken in an inpatient neurology department of an urban, periphery, academic medical centre. Results A total of 118 patients with stroke were included in the study; 32 were treated 3 months before the physical and rehabilitation medicine doctor worked on the ward, 43 during, and 43 after the physical and rehabilitation medicine doctor left the department. Statistical comparative analysis showed that length of stay was significantly reduced when there is a physical and rehabilitation medicine doctor present among the neurology ward physicians (18.06 days before intervention, 12.39 days during and 14.12 days after). Conclusions Having a physical and rehabilitation medicine doctor in the neurology department can shorten the length of stay in patients with stroke. Were larger studies to confirm these findings, the authors would recommend incorporating a physical and rehabilitation medicine doctor in neurology departments.
A biopsychosocial model of severe fear of COVID-19
Authors: Nürnberger Patrick , von Lewinski Dirk , Rothenhäusler Hans-Bernd , Braun Celine , Reinbacher Patrick , Kolesnik Ewald , Baranyi Andreas 
Published: February 2022

Introduction
COVID-19 is a respiratory infection that causes not only somatic health issues, but also frequently psychosocial burdens. The aims of this study were to investigate biopsychosocial factors that might further aggravate fear of COVID-19, and to establish a biopsychosocial model of severe fear of COVID-19.

Methods
368 participants were included in this study. Biopsychosocial factors observed comprised biological factors (somatic risk), psychological factors (state/trait anxiety, physical symptoms of anxiety, severe health anxiety, specific phobias, depression), and psychosocial factors (social support, financial losses, social media consumption, social contacts with COVID-19 infected people). Psychometric questionnaires included State-Trait Anxiety Inventory, Beck’s Anxiety Inventory, Whiteley-Index / Illness Attitude Scales, Specific Phobia Questionnaire, WHO-5 and Social Support Survey.

Results
162/368 (44.0%) participants had almost no fear, 170/368 (46.2%) participants had moderate fear, and 45/368 (12.2%) participants had severe fear of COVID-19. Female participants showed higher levels of fear of COVID-19 than male participants (gender: χ2 = 18.47, p<0.001). However, the level of fear of COVID-19 increased in male participants when they had contact with people who were infected with COVID-19, while in contrast the level of fear of COVID-19 decreased in female participants when they had such contacts [ANCOVA: fear of COVID-19 (contact x gender): F(1,363) = 5.596, p = .019]. Moreover, participants without relationships showed higher levels of fear of COVID-19 (marital status: χ2 = 14.582, p = 0.024). Furthermore, financial losses due to the COVID-19 were associated with higher levels of fear of COVID-19 [ANCOVA: fear of COVID-19(financial loss x gender): F(1, 363) = 22.853, p< .001]. Multiple regression analysis revealed female gender, severe health anxiety (WI-IAS) and state /trait anxiety (STAI) as significant predictors of severe fear of COVID-19.

Conclusion
In this study significant predictors of severe fear of COVID-19 were female gender, pre-existing state and trait anxiety, as well as severe health anxiety. The finding of significant predictors of fear of COVID-19 might contribute to detect people who might suffer most from severe, overwhelming fear of COVID-19 at an early stage.
Hubungan Ketersediaan Sanitasi Dasar terhadap Status Gizi Baduta di Desa Pelem, Bojonegoro
Authors: Basyariyah Qonita , Diyanah Khuliyah Candraning , Pawitra Aditya Sukma 
Published: February 2022

Latar belakang: Sanitasi lingkungan dasar merupakan salah satu faktor yang mempengaruhi status gizi baduta. Berdasarkan data dari Puskesmas Purwosari sebanyak 11 baduta memiliki status gizi kurang dan 8 diantaranya berasal dari Desa Pelem. Penelitian ini bertujuan untuk menganalisis hubungan ketersediaan sanitasi dasar dengan status gizi pada baduta di Desa Pelem, Bojonegoro.Metode: Penelitian ini merupakan penelitian observasional dengan rancangan cross sectional. Lokasi penelitian di Desa Pelem, Kecamatan Purwosari, Kabupaten Bojonegoro yang dilaksanakan pada tanggal 28 Desember 2019 – 14 Januari 2020. Sampel pada penelitian ini yaitu total dari populasi seluruh baduta sebanyak 51 anak. Variabel yang diteliti yaitu status gizi baduta, sumber air bersih, ketersediaan jamban sehat, dan kepemilikan SPAL. Data diperoleh dari hasil observasi dan wawancara yang kemudian dianalisis menggunakan uji chi-square.Hasil: Mayoritas masyarakat Desa Pelem mengambil sumber air bersih yang berasal dari sumur (94,0%), rumah yang telah memiliki jamban sehat hanya 60,7% dan 58,8% belum memiliki SPAL. Hasil analisis menunjukkan ketersediaan jamban sehat (p=0,004 < α) dan kepemilikan SPAL (p=0,015 < α) memiliki hubungan yang signifikan terhadap status gizi pada baduta.Simpulan: Ada hubungan antara ketersediaan jamban sehat dan kepemilikan SPAL terhadap status gizi baduta, sehingga strategi terhadap ketersediaan jamban sehat dan SPAL perlu dilakukan untuk menurunkan risiko status gizi kurang pada baduta. Title: Analysis Availability of Basic Sanitation On Nutritional Status Of Baduta In Pelem Village, Bojonegoro.Background: Environmental basic sanitation is one of the factor affect the nutritional status of baduta. Based on data from Purwosari Health Center as many as 11 baduta have undernutrition status and 8 between them are from Pelem Village. Study aims to analyze availability of basic sanitation with nutritional status in under-fives in Pelem Village, Bojonegoro.Method: This research is an observational study with a cross sectional design. The research location was in Pelem Village, Purwosari District, Bojonegoro Regencyon 28 December 2019 – 14 January 2020. The sample in this study was the total population of all baduta with a total of 51 children. The variables studied are baduta nutritional status, availability of health latrines, and SPAL ownership. The data was obtained from observations and interviews then were analyzed using the chi-square test.Result: The majority of the people in Pelem Village took clean water from wells (94.0%), there were houses that have health latrine just 60,7% and about 58.8% did not have sewerage. Availability of healthy latrines (p=0,004 < α) and sewerage ownership (p=0,015 < α) have a significant relationship with nutritional status in under-fives.Conclusion: There is a relationship between the availability healthy latrines and sewerage ownership on the nutritional status of under-five children.
Kähler spaces with zero first Chern class: Bochner principle, Albanese map and fundamental groups
Authors: Claudon Benoît , Graf Patrick , Guenancia Henri , Naumann Philipp 
Published: February 2022

AbstractLetXbe a compact Kähler space with klt singularities and vanishing first Chern class. We prove the Bochner principle for holomorphic tensors on the smooth locus ofX: any such tensor is parallel with respect to the singular Ricci-flat metrics. As a consequence, after a finite quasi-étale coverXsplits off a complex torus of the maximum possible dimension. We then proceed to decompose the tangent sheaf ofXaccording to its holonomy representation. In particular, we classify thoseXwhich have strongly stable tangent sheaf: up to quasi-étale covers, these are either irreducible Calabi–Yau or irreducible holomorphic symplectic. As an application of these results, we show that ifXhas dimension four, then it satisfies Campana’s Abelianity Conjecture.
Corrigendum to Intrinsic flat stability of the positive mass theorem for graphical hypersurfaces of Euclidean space (J. reine angew. Math. 727 (2017), 269–299)
Authors: Huang Lan-Hsuan , Lee Dan A. , Sormani Christina 
Published: February 2022

Abstract
There is an error in the proof of Theorem 1.3 of the original article.
Despite the problem, it is rigorously proved in joint work of the first two authors and Perales that Theorem 1.3 is true, using recent results of Allen and Perales that extend the work of Allen, Perales, and Sormani.
The efficacy of topical Marham-e-Akbar in chronic atopic dermatitis – an open-label interventional study
Authors: Imran Shaikh , Khalid Mohd , Husain Nazim , Khan Mohd Qudrathullah , Shaikh Shalina 
Published: February 2022

Abstract

Objectives
Chronic atopic dermatitis (AD) is an inflammatory skin condition marked by intense pruritus, dry skin, and severe impact on the life quality of the patients. Conventionally, it is managed by using emollients, calcineurin inhibitors, and topical corticosteroids. In Unani medicine, eminent scholars advocated many drug formulations including topical Marham-e-Akbar for effective healing of AD but scientific evidence is scarce. Hence, this study was designed.

Methods
This was a single-arm clinical trial conducted on 30 participants aged 18–65 years suffering from chronic AD after obtaining written informed consent. The trial intervention was Marham-e-Akbar consisting of Murdār Sang (Plumbi oxidum); Sindūr (red lead); olive oil (Olea europaea oil); Kath (Acacia catechu extract); Safeda Kāshgari (Zinc oxide); Sirka (vinegar); and Phitkirī (alum) to be applied twice daily for 42 days. The objective parameters were SCORAD and DLQI, while the subjective parameters included itching, scaling, and erythema assessed on a customized VAS scale and 4-point Likert scale.

Results
The pre-post analysis inferred statistically significant attenuation in subjective parameters (itching, scaling, and erythema) and objective scales (SCORAD) and (DLQI) with p<0.001.

Conclusions
The study findings deduced that Marham-e-Akbar is effective in the amelioration of chronic atopic dermatitis and quality of life of the patients as well.
Feasibility study of a self-consumption photovoltaic installation with and without battery storage, optimization of night lighting and introduction to the application of the DALI protocol at the University of Ibn Tofail (ENSA/ENCG), Kenitra – Morocco
Authors: Choukai Oumaima , El Mokhi Chakib , Hamed Ahmed , Ait Errouhi Ahmed 
Published: February 2022

Abstract
Energy is at the center of most of the major challenges of our society, but equally at the center of the promising perspectives that the world is facing. In fact, the combination of wind, water and solar energy can replace depleting fossil fuels which produce greenhouse gases on the one hand, and on the other hand cover the entire energy needs of the planet. Solar energy is both clean and non-polluting, moreover it is one of the most popular solutions for households as an alternative to fossil fuels. Therefore, the use of photovoltaic systems reduces the energy supplied by the public grid and inevitably decreases the amount of the energy invoice in the long term. Due to the increase in the number of bachelor students in recent years, the Ibn Tofail University in Kenitra, Morocco, has been required to build new buildings and laboratories to ensure a good study environment for its students. This has led to an enormous increase in the electricity bill. In this context, our project aims to decrease the energy bill of the two institutions: National School of Applied Sciences (ENSA) as well as National School of Commerce and Management (ENCG), by studying the technical and economic aspects of photovoltaic installations for self-consumption purposes, as well as the installation of solar streetlamps to improve the performance of nocturnal lighting. In addition, an initiation to the intelligent smart building concept that allows the centralized technical management of the installed equipment, and more precisely the DALI lighting protocol, was extended. Indeed, this system will allow us to control the consumption of the loads remotely and in real time for a better comfort and without neglecting the reduction of the energy bill.
Distribution of cadmium accumulated in the wood cells of poplar
Authors: Rong Gong , Liu Shengquan , Chu Yin , Yu Min 
Published: February 2022

Abstract
Poplar is an important tree species in the phytoremediation of Cadmium (Cd) in the soil. However, the research on its transport and accumulation mechanism in wood cells has not been conducted. In this paper, Poplar 69 [Populus deltoides Bartr. cv. ‘Lux’ (I-69/55)] was selected to study the distribution of Cd accumulated in the wood, both macroscopically, by Cd analysis along the trunk heights, and microscopically, by scanning electron microscope with energy dispersion spectrum (SEM-EDS) observation, through a pot experiment, where four treatments with different Cd application in the soil and one control without Cd addition were set. The results demonstrated that the Cd concentration in the wood of all heights increased significantly with the increase of Cd addition in the soil and it also increased, though not significantly, from the basal to the top along the trunk heights at all treatments. Through SEM-EDS Cd was found to be accumulated in the inner wall and pits of the vessels, the wood fibers, and the wood rays, indicating that Cd could enter all three types of wood cells. The distribution of Cd in the three types of wood cells followed the order as wood fiber > vessel > wood ray, based on the calculation of the proportion of Cd enrichment spots in different types of cells. About half of the Cd in the wood was stored permanently in the wood fibers with the rest being in the vessels and wood rays probably temporally.