bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the genetic correlation and causal relationship between osteoarthritis and human blood metabolites
Authors: Shen Bin , Xu Jiawen , Si Haibo , Zeng Yi , Wu Yuangang , Li Mingyang 
Published: March 2022

Abstract
Objective: Osteoarthritis (OA) is a common musculoskeletal disease and a significant source of pain, disability, and socioeconomic cost worldwide. Genetic factors play important roles in the development of OA. However, the genetic basis of OA remains elusive now. Methods: Utilizing recently released large-scale genome-wide association study (GWAS) summary statistics of OA and 529 human blood metabolites, we explored the potential associations between OA and human blood metabolites from three aspects. Firstly, linkage disequilibrium score regression (LDSC) was applied to detect genetic correlations between OA and each of the 529 blood metabolites. Secondly, Mendelian Randomization (MR) analysis was used to evaluate the causal relationship between OA and significant blood metabolites identified by LDSC. Finally, mRNA expression and DNA methylation profiles of OA were used to detect the differentially expressed gene (DEG) and differentially methylated gene (DMG) which related to the blood metabolites identified by LDSC.Results: LDSC analysis found 19 candidate human blood metabolites showing genetic correlation signals with OA, such as citrate (genetic correlation coefficient (rg) = -0.2285, P value = 0.0034), proline (rg = 0.1777, P value = 0.0272), leucine (rg = 0.0891, P value = 0.0431), valine (rg = 0.1565, P value = 0.0405), methylcysteine (rg = -0.2488, P value = 0.0391) and 1-palmitoylglycerophosphoinositol (rg =0.3514, P value = 0.0434). MR analysis identified a significant causal relationship between OA and 1,6-anhydroglucose (β = -1.755, SE = 0.7992, P = 0.0281). mRNA expression and DNA methylation analysis identified FMO3 was the DEG and the LIPC was the DMG, which were related to methylcysteine and 1-palmitoylglycerophosphoinositol.Conclusion: Our results provide novel clues for understanding the genetic mechanism of OA, focusing on the possible roles of abnormal human blood metabolites in the pathogenesis of OA.
A Logit-Based Binary Classifier of Tsunamigenic Earthquakes for the Northern Pacific Ocean
Authors: Konovalov Alexey , Samsonov Grigory , Stepnov Andrey 
Published: March 2022

Abstract
In this study, logistic regression was used as a tool for deriving the binary classifier of tsunamigenic and nontsunamigenic earthquakes in the near-source zone. Earthquake source depth and moment magnitude were considered as predictors. The training dataset consisted of 767 M6.0+ submarine earthquakes, including 80 tsunamigenic and 687 nontsunamigenic events that occurred in the northern part of the Pacific Ocean from 1960 to 2020. The target area has already experienced significant and catastrophic tsunamis. The current analysis clearly showed that the data-driven logit model had a significantly lower false discovery rate relative to the threshold magnitude criteria that are widely used by tsunami warning agencies. At the same time, the balanced accuracy was about 71%, which suggests optimism for accurate tsunami forecasting based on the rapid interpretation of earthquake source parameters.
Prognostic Implications for Patients After Myocardial Infarction: an Integrative Literature Review and in-depth Interviews With Patients and Experts
Authors: Hwang Seon Young , Kim Sun Hwa , Uhm In Ae , Shin Jeong-Hun , Lim Young-Hyo 
Published: March 2022

Abstract
Background: As patients with myocardial infarction (MI) survive for a long time after acute treatment, it is necessary to pay attention to the prevention of poor prognosis such as heart failure (HF). To identify the influencing factors of adverse clinical outcomes through a review of prospective cohort studies of post-MI patients, and to draw prognostic implications through in-depth interviews with post-MI patients who progressed to HF and clinical experts. Methods: A mixed-method design was used that combined a scoping review of 21 prospective cohort studies, in-depth interviews with Korean post-MI patients with HF, and focus group interviews with cardiologists and nurses. Results: A literature review showed that old age, diabetes, high Killip class, low left ventricular ejection fraction, recurrent MI, comorbidity of chronic disease and current smoking, and low socioeconomic status were identified as influencing factors of poor prognosis. Through interviews with post-MI patients, these influencing factors identified in the literature as well as a lack of disease awareness and lack of self-care were confirmed. Experts emphasized the importance of maintaining a healthy lifestyle after acute treatment with the recognition that it is a chronic disease that must go together for a lifetime. Conclusion: This study confirmed the factors influencing poor prognosis after MI and the educational needs of post-MI patients with transition to HF. Healthcare providers should continue to monitor the risk group, which is expected to have a poor prognosis, along with education emphasizing the importance of self-care such as medication and lifestyle modification.
Potent insecticidal activity of Eleocharis dulcis peel extract and its main components against aphids
Authors: Li Jingjing , Wang Mingsi , Zhao Yujing , Yu Hualong , Zhang Xinxin , Feng Yingjian , Dong Lili , Zhang Lihui , Dong Jinggao , Li Yaofa , Ma Shujie 
Published: March 2022

Abstract
Aphids are significant pests of the cash crops and food farm crops. Botanical insecticides are safe for aphid control, especially in organic agriculture. In this study, Eleocharis dulcis peel extract (EDPE), a new botanical insecticide, was investigated for its active compositions against several agricultural aphids. The results showed that the EDPE had high insecticidal activity against Sitobion avenae, Aphis gossypii, Megoura crassicauda, and Acyrthosiphon pisum, with the half lethal concentration (LC50) values of 95.92, 81.04, 140.31, and 255.73 mg/L after 48 h treatment. In the pot culture assay, the aphicidal effects of 25% EDPE soluble liquid (SL) at a concentration of 0.016% were 68.98%, 79.33%, and 88.82% after the 1st, 3rd, and 7th days of treatment, respectively. Nine compounds were identified by bioactivity-directed fractionation, which was dimethoxy-6, 6-dimethylpyranoisoflavone (1), 3-methoxy-4-hydroxylonchocarpin (2), 4-hydroxylonchocarpin (3), 4-methoxylonchocarpin (4), barbigerone (5), lonchocarpusone (6), 6a, 12a-dehydrodeguelin (7), 13-homo-13-oxa-6a,12a-dehydrodeguelin (8) and deguelin (9). Among them, 4-hydroxylonchocarpin (3) showed the highest aphidicidal activity against M. crassicauda, S. avenae, and A. pisum, with the LC50 values of 97.24, 140.63, and 112.31 mg/L, respectively. Therefore, EDPE and its major component 4-hydroxylonchocarpin are probably used as new botanical insecticides to control aphids.
Behavioral toxicity and pharmacokinetics of PCB 77 and PCB 180 in Swiss albino mouse: A single dose inhalation toxicity risk assessment
Authors: Muthusamy Sivaselvakumar , Narayanan Ramanujam 
Published: March 2022

Abstract
Purpose: Polychlorinated Biphenyls pose hazards to humans as environmental and occupational workplace pollutants, despite which, though they are regulated in India, their use is not yet banned. Hence, the pharmacokinetics and behavioral effects of PCBs after inhalational exposures of Aroclor 1232 in Swiss albino mice were assessed in this study, with an objective to correlate these effects with monoamine levels in brain and extrapolate them to rodent and human risk assessments. Methods: A whole body inhalational chamber has been utilized to expose mice to different doses of Aroclor 1232 for single six-hour durations. The plasma and brain samples were harvested at nine different time points during and after the exposures. These samples were used to estimate the corresponding concentration-time profiles of two representative congeners of PCBs (PCB 77 and PCB 180) and calculate their pharmacokinetic parameters. These variables were then correlated with mouse behavior using Irwin scale, and monoamine levels at Tmax.Results: A definite dose-dependence of PCB 77 and PCB 180 pharmacokinetic parameters was identified in plasma and brain. PCB 77 exhibited more accumulation in brain than plasma, whereas PCB 180 accumulated more in plasma than brain. Mood, autonomic scores, and miscellaneous sub domains were significantly different from control group scores in these domains. The changes in the mood and miscellaneous domains on the Irwin scale could be ascribed to higher brain PCB 77 AUC0-t; whereas changes in autonomic functions could be ascribed to higher plasma PCB 180 levels. Dose-responses with monoamines followed linear (5-HT), non-monotonic (DA) and exponential (NA) relationships till 6 hours of exposure. Conclusion: The pharmacokinetic parameters of PCB 180 and PCB 77 after acute inhalational exposures to Aroclor 1232 were obtained and this was temporally correlated with disruption of behavioral scores in dose-dependent manner. These could have a relationship with brain monoamine changes at Tmax.
Influence of Playing Position, Training Day and Match on the Acceleration - Speed Profile of Elite Football Players
Authors: Alonso-Callejo Antonio , Garcia-Unanue Jorge , Perez-Guerra Andres , Gomez David , Sanchez-Sanchez Javier , Gallardo Leonor , Oliva-Lozano Jose Maria , Felipe Jose Luis 
Published: March 2022

Abstract
The acceleration-speed profile (A-S profile) is a new method to evaluate physical and determinant capabilities such as acceleration (ACC) and speed (S) in sports. The aim of this study was to analyze the differences in the A-S profile of elite football players induced by playing position and microcycle day. Players belonged to a second division club of Spanish competition La Liga. They were classified into six playing positions: central defenders (CD), full backs (FB), midfielders (MF), wide midfielders (WMF) and forwards (FW). Data was collected along six microcycles including one match per microcycle. The variables analyzed included: maximal theoretical acceleration (A0), maximal theoretical speed (S0), maximal acceleration (ACCmax), maximal speed (Smax) and A-S slope (ASslope). Significance differences were found within positions and microcycle day for all variables (p<0.05). MD showed greater values than the training sessions in A0, ACCmax and Smax (p<0.05). Highest values for variables associated to acceleration capabilities were found in CD on MD, whereas speed variables were higher in WMF. MD-2 showed the lowest values in all variables except for ASslope. In conclusion, the results show that exist differences on the A-S profile depending on the playing position and the microcycle day. Assessing the A-S profile could help to individualize the training sessions depending on playing position demands and to check that competitions requirements are achieved during microcycle.
Diagnostic Value of Fully Automated Artificial Intelligence Powered Coronary Artery Calcium Scoring from 18F-FDG PET/CT
Authors: Morf Claudia , Sartoretti Thomas , Gennari Antonio G. , Maurer Alexander , Skawran Stephan , Giannopoulos Andreas A. , Sartoretti Elisabeth , Schwyzer Moritz , Curioni-Fontecedro Alessandra , Gebhard Catherine , Buechel Ronny , Kaufmann Philipp A. , Huellner Martin W. , Messerli Michael 
Published: March 2022

Abstract
Purpose: To assess the feasibility and accuracy of a fully automated artificial intelligence (AI) powered coronary artery calcium scoring (CACS) method on ungated CT in oncologic patients undergoing 18F-FDG PET/CT.Materials and Methods: A total of 100 oncologic patients examined between 2007 and 2015 were retrospectively included. All patients underwent 18F-FDG PET/CT and cardiac SPECT myocardial perfusion imaging (MPI) by 99mTc-tetrofosmin within 6 months. CACS was manually performed on non-contrast ECG-gated CT scans obtained from SPECT-MPI (i.e. reference standard). Additionally, CACS was performed fully automatically using a cloud-based, user-independent tool (AI-CACS) on non-contrast, free-breathing, ungated CT scans from 18F-FDG-PET/CT examinations. Agatston scores from the manual CACS and AI-CACS were compared. Results: On a per-patient basis, the AI-CACS tool achieved a sensitivity and specificity of 85% and 90% for the detection of coronary calcifications. Interscore agreement of CAC scores between manual CACS and AI-CACS was 0.88 (95% CI: 0.827, 0.918). Interclass agreement of risk categories was 0.8 in weighted Kappa analysis with a reclassification rate of 44% and an underestimation of one risk category by AI-CACS in 39% of cases. On a per-vessel basis, interscore agreement of CAC scores ranged from 0.716 (95%CI: 0.605, 0.799) for the circumflex artery to 0.863 (95%CI: 0.803, 0.906) for the left anterior descending artery. Conclusion: Fully automated AI-CACS as performed on non-contrast free-breathing, ungated CT scans from 18F-FDG-PET/CT examinations is feasible and provides a good estimation of CAC burden. CAC load on ungated CT is, however, generally underestimated by AI-CACS which should be taken into account when considering recommending further diagnostic workup for coronary heart disease.
Impact of Short-term Weight Loss on Hemostasis and Trombosis After Obesity Surgery
Authors: Taha Ahmed , Eroglu Hasan , DEMİRBAŞ İskender Eren , DEMİR Berkay 
Published: March 2022

Abstract
Background
Metabolic disorders such as deficiency of vitamins and electrolyte imbalance may cause coagulation problems after bariatric surgery. In early postsurgical period, deplation of vitamin K dependent coagulation factors may increase the risk of hemorrhage.
Aim
We aimed to evaluate the outcomes of rapid weight loss in early period after bariatric surgery on coagulation system.
Materials & Method
This study had a prospective nature. We have enrolled 28 patients with a BMI < 40 kg/m2 who underwent bariatric surgery in our institution. Patients were discharged with vitamin K free multivitamin complex medication. Preoperative and postoperative (at the end of first and third months) demographic criterias – such as age, gender, weight, height, use of alcohol and/or tabacco and biochemical parameters such as PLT, PT, aPTT, INR, bleeding time, coagulation time, fibrinogen, D – Dimer, albümin, calcium, ionized calcium, vitamin D and PTH were analyzed.
Results
The success of bariatric operation has been elaborated with the weight loss in the first month compared top pre-operative period (p < 0.001), decrease in BMI in the first month compared top pre-operative period (p < 0.001), weight loss in the third month compared to pre-operative period (p < 0.001), decrease in BMI in the third month compared top pre-operative period (p < 0.001), weight loss in the third month compared to first month (p < 0.001) and decrease in BMI in the third month compared to first month. The first month % EWL and % EBMIL scores were 21.7% (ranging between 13.0–45.6%) and 25.2% (13.8–49.7%) respectively. The third month %EWL and % EBMIL scores were 40.6% (ranging between 27.1–67.5%) and 45.5% (ranging between 29.4–76.6%).
Conclusion
Tromboembolic events have crucial importance with the converse scenario of hemorrhagic diathesis during the first months of obesity surgery. In early postoperative period, vitamin support and low dose antitrombotic agents should be recommended.
A prediction model for risk factors of stage II to III colon cancer based on postoperative serum carcinoembryonic antigen and tumor deposition: a retrospective multicenter cohort study
Authors: Pu Hongjiang , Pang Xiaolin , Chen Yaxue , Ma Jianguo , Wu Runhong , Zhang Dafu 
Published: March 2022

Abstract
Purpose: This study aimed to establish a recurrence risk prediction model composed of postoperative CEA combined with pathological features for postoperative recurrence risk stratification in stage II to III colon cancer. Methods: A retrospective analysis of 1,321 patients who underwent radical surgery for stage II/III colon cancer from April 2008 to January 2019. Cox proportional hazards regression model was used to analyze the independent recurrence prognostic factors of patients with recurrence-free survival (RFS). The recurrence risk score was established based on independent recurrence prognostic factors, and the Kaplan-Meier method was used to draw the patient's recurrence-free survival curve and overall survival (OS) curve.Results: The median follow-up period of all patients was 49.73 months. Multivariate analysis of COX proportional hazards model showed that postoperative CEA increased (HR, 2.0; 95% CI, 1.1-3.5), higher stage N (HR, 2.0; 95 % CI, 1.1-3.5), tumor deposition (HR, 2.0; 95% CI, 1.1-3.5) is independently associated with shorter RFS. The recurrence risk score is an independent stratified prognostic factor of RFS and OS.Conclusion: Based on postoperative CEA, N stage and tumor deposition positive are powerful predictors of recurrence survival and prognosis for patients with stage II to III colon cancer.
On fault vs. off-fault seismicity: the role of rock vs. fault rheology
Authors: Collettini Cristiano , De Paola Nicola , Barchi Massimiliano , Trippetta Fabio , Tinti Elisa 
Published: March 2022

Abstract
Analysis of seismicity can illuminate active fault zone structures but also pervasive deformation occurring within large volumes of the seismogenic zone. Here we show that, for the Mw 6.5 2016–2017 Central Italy seismic sequence, seismicity not only localizes along SW-dipping normal faults, but also occurs within larger volumes of Triassic Evaporites, TE, composed of alternated anhydrites and dolostones. This off-fault and diffuse microseismicity shows a different frequency-magnitude distribution than on-fault seismicity along the structures hosting the largest events. We interpret that, during the sequence, shear strain-rate increase promoted widespread ductile deformation within TE that light-up with diffuse microseismicity. This interpretation is supported by field and laboratory observations showing that TE background ductile deformation is complex and dominated by distributed failure and folding of the anhydrites associated with boudinage fracturing and faulting of dolostones. Our results indicate that ductile crustal deformation can cause off-fault and diffuse microseismicity, which obeys to different scaling laws than on-fault seismicity on structures characterized by elasto-frictional stick-sip behaviour.
Assessment of ground deformation and seismicity associated to fluid injection and oil/gas extraction in the Argentinian Patagonia
Authors: Tamburini-Beliveau Guillermo , Grosso-Heredia Javier A. , Béjar-Pizarro Marta , Pérez-López Raúl , Portela-Fernández Juan , Cismondi-Duarte Martín , Monserrat Oriol 
Published: March 2022

Abstract
The exploitation of both conventional and non-conventional hydrocarbons may lead to still not well-known environmental consequences such as ground deformation and induced/triggered seismicity. Identifying and characterizing these effects is fundamental for prevention or mitigation purposes, especially when they impact populated areas. Two case studies of such effects on hydrocarbon-producing basins in Argentina, the Neuquén and the Golfo de San Jorge, are presented in this work. The intense hydrocarbon production activities in recent years and their potential link with the occurrence of two earthquakes of magnitude 4.9 and 5 near the operating well fields is assessed. A joint analysis of satellite radar interferometry and records of fluid injection and extraction demonstrate that, between 2018 and 2020, vertical ground displacements occurred in both study areas over active well fields that might indicate a correlation to hydrocarbon production activities. Coseismic deformation models of the two earthquakes constrain source depths to less than 2 km. The absence of seismicity before the beginning of the hydrocarbon activities in both areas, and the occurrence of the two largest and shallow earthquakes in the vicinity of the active well fields just after intensive production periods, points towards the potential association between both phenomena.
Computerized Three-dimensional Cephalometric Template for Thai Adults
Authors: Duangsuwan Jeenarat , Raocharernporn Somchart , Thiradilok Sasipa , Manopatanakul Somchai 
Published: March 2022

Abstract
Background: With its increased accessibility, the use of cone-beam computed tomography (CBCT) is gradually expanding around the world. CBCT images can be reconstructed to form three-dimensional (3D) images that resemble the actual morphology of a patient's skull, and this can be useful in cephalometric analysis and teledentistry. In this study, we aimed to develop 3D templates for Thai adults based on cephalometric landmark coordinates obtained from skull CBCT scans.Methods: Full head CBCT scans of a total of 39 subjects (18 males and 21 females) were obtained. The scans were taken in a normal head position and the coordinates of 21 important cephalometric landmarks were identified using Slicer 4.10.2 software. Intraclass correlation coefficients (ICC) and Bland-Altman plots were used to assess inter- and intra-examiner reliability. Independent samples t-tests were used to compare all mean coordinates between male and female subjects. Results: All landmark coordinates were accurately traced and analyzed. ICC values of 0.97-0.99 were obtained, confirming measurement reliability. Most of the Z-axis coordinates were statistically different between males and females. As a result, using the means of the landmark coordinates, 3D cephalometric templates for adult Thai males and females were generated separately.Conclusion: 3D cephalometric templates for Thai adults were created, and it is recommended to be used most effectively for Thai adults to detect deviations in skull morphology from the population norm.
Assessment of left atrial functions in active rheumatoid arthritis patients using different echo-Doppler modalities.
Authors: Elbeialy Adel , Elnaggar Basma , Abou-Elhassan Hanaa , roshdy Eman , Sabry Seham , Al-Ghoubary Mohamed , Zaki Eman 
Published: March 2022

Abstract
Background: left atrium (LA) plays an important role in maintaining optimal cardiac output. Rheumatoid arthritis (RA) has been considered an independent cardiovascular risk factor that can affect all cardiac chambers and functions, especially in active disease.Aim of the study: To evaluate the effect of the activity of rheumatoid arthritis disease on left atrial functions using different echo-Doppler modalities.Methods: Sixty-five patients with RA without evidence of previous cardiovascular disease and 36 healthy control subjects were included. Echo-Doppler examination was done with measurements included LV dimensions, ejection fraction, trans-mitral Doppler flow and tissue Doppler velocities , LA dimensions, volumes, phasic LA peak strain and LA global longitudinal strain. Results: 39 patients had an active disease while 26 were in remission. The two patients’ groups had higher values of LV internal dimensions, LA volumes, and early diastolic peak strain as a surrogate of the conduit function compared to the control group. On the other hand, they had lower values of LV-EF, FS, mitral E/A ratio & Em and lower values of parameters of reservoir & contractile function, compared to the control subjects. There were no significant differences between the 2 patients’ groups in all measures except for a significantly lower value of LA GLS in active RA compared to patients in remission (p=0.001). The LA-GLS correlated significantly with RA disease activity score (r=0.60, p<0.001).Conclusion: LA function is impaired in RA and this impairment correlates with the disease activity. The LA-GLS is superior in the detection of subclinical left atrial dysfunction.