bluuebunny/crossref_metadata_2025_split huggingface dataset:
The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis
Authors: Yuan Yuan , Fan Guangjian , Liu Yuqi , Liu Lu , Zhang Tong , Liu Pengfei , Tu Qing , Zhang Xinyi , Luo Shiyuan , Yao Liangfang , Chen Feng , Li Jingbao 
Published: January 2022

AbstractSepsis is a heterogeneous syndrome induced by a dysregulated host response to infection. Glycolysis plays a role in maintaining the immune function of macrophages, which is crucial for severely septic patients. However, how the pathways that link glycolysis and macrophages are regulated is still largely unknown. Here, we provide evidence to support the function of KLF14, a novel Krüppel-like transcription factor, in the regulation of glycolysis and the immune function of macrophages during sepsis. KLF14 deletion led to significantly increased mortality in lethal models of murine endotoxemia and sepsis. Mechanistically, KLF14 decreased glycolysis and the secretion of inflammatory cytokines by macrophages by inhibiting the transcription of HK2. In addition, we confirmed that the expression of KLF14 was upregulated in septic patients. Furthermore, pharmacological activation of KLF14 conferred protection against sepsis in mice. These findings uncover a key role of KLF14 in modulating the inflammatory signaling pathway and shed light on the development of KLF14-targeted therapeutics for sepsis.
SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages
Authors: Wang Zhenfeng , Lv Jiadi , Yu Pin , Qu Yajin , Zhou Yabo , Zhou Li , Zhu Qiangqiang , Li Shunshun , Song Jiangping , Deng Wei , Gao Ran , Liu Yuying , Liu Jiangning , Tong Wei-Min , Qin Chuan , Huang Bo 
Published: January 2022

AbstractExploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy. Here, we show that ACE2-overexpressing A549 cell-derived microparticles (AO-MPs) are a potential therapeutic agent against SARS-CoV-2 infection. Intranasally administered AO-MPs dexterously navigate the anatomical and biological features of the lungs to enter the alveoli and are taken up by alveolar macrophages (AMs). Then, AO-MPs increase the endosomal pH but decrease the lysosomal pH in AMs, thus escorting bound SARS-CoV-2 from phago-endosomes to lysosomes for degradation. This pH regulation is attributable to oxidized cholesterol, which is enriched in AO-MPs and translocated to endosomal membranes, thus interfering with proton pumps and impairing endosomal acidification. In addition to promoting viral degradation, AO-MPs also inhibit the proinflammatory phenotype of AMs, leading to increased treatment efficacy in a SARS-CoV-2-infected mouse model without side effects. These findings highlight the potential use of AO-MPs to treat SARS-CoV-2-infected patients and showcase the feasibility of MP therapies for combatting emerging respiratory viruses in the future.
Effects of DISC1 on Alzheimer’s disease cell models assessed by iTRAQ proteomics analysis
Authors: Lu Jiajie , Huang Rihong , Peng Yuecheng , Wang Haojian , Feng Zejia , Fan Yongyang , Zeng Zhaorong , Wang Yezhong , Wei Jiana , Wang Zhaotao 
Published: January 2022

Abstract
Alzheimer’s disease (AD) is a form of neurodegenerative disease in the elderly with no cure at present. In a previous study, we found that the scaffold protein, disrupted in Schizophrenia 1 (DISC1) is down-regulated in the AD brains, and ectopic expression of DISC1 can delay the progression of AD by protecting synaptic plasticity and down-regulating BACE1. However, the underlying mechanisms remain not to be elucidated. In the present study, we compared the proteomes of normal and DISC1high AD cells expressing the amyloid precursor protein (APP) using isobaric tag for relative and absolute quantitation (iTRAQ) and mass spectrometry (MS). The differentially expressed proteins (DEPs) were identified, and the protein–protein interaction (PPI) network was constructed to identify the interacting partners of DISC1. Based on the interaction scores, NDE1, GRM3, PTGER3 and KATNA1 were identified as functionally or physically related to DISC1, and may therefore regulate AD development. The DEPs were functionally annotated by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases with the DAVID software, and the Non-supervised Orthologous Groups (eggNOG) database was used to determine their evolutionary relationships. The DEPs were significantly enriched in microtubules and mitochondria-related pathways. Gene set enrichment analysis (GSEA) was performed to identify genes and pathways that are activated when DISC1 is overexpressed. Our findings provide novel insights into the regulatory mechanisms underlying DISC1 function in AD.
Systematic Review and Meta-Analysis of Dysphagia and Associated Pneumonia in Patients With Stroke From India: A Call to Arms
Authors: Krishnamurthy Rahul , Balasubramanium Radish Kumar , Premkumar Priya Karimuddanahalli 
Published: January 2022

Objectives:
This study aimed to determine the prevalence of reported dysphagia and associated pneumonia risk among patients with stroke in India.

Method:

We carried out a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The primary outcome of interest was dysphagia and pneumonia among patients with stroke in India. Two review authors independently assessed the quality of studies using the Newcastle–Ottawa Scale and extracted related data. Meta-analysis was performed for frequency of dysphagia, associated pneumonia, and its relative risk using a random-effects model. Statistical heterogeneity was computed using the

I
2

index.

Results:

A total of 3,644 titles were screened, and only eight studies met our inclusion criteria. Based on data from these studies, we calculated the pooled prevalence of dysphagia (47.71%; 95% confidence interval [CI] [20.49%, 70.92%],
p
< .001) and pneumonia (20.43%; 95% CI [10.73%, 30.14%],
p
< .001) for patients with stroke in India. We found that the relative risks of pneumonia in patients with stroke and dysphagia versus those patients with stroke and no dysphagia was 9.41 (95% CI [5.60, 15.80],
p
< .001). Data on length of hospital stay and rates of mortality secondary to pneumonia are also presented.

Conclusions:
Despite the high incidence of dysphagia and associated pneumonia, the methodological quality of studies is fair and there is little research focused on epidemiological data. We call to arms to those SLPs working with patients with stroke in India to become proactive in both clinical practice and research domains.

Supplemental Material

https://doi.org/10.23641/asha.17701022
Nonword Repetition Performance Differentiates Children Who Stutter With and Without Concomitant Speech Sound and Developmental Language Disorders
Authors: Gerwin Katelyn L. , Walsh Bridget , Tichenor Seth E. 
Published: January 2022

Purpose:
The aim of this study was to examine how nonword repetition (NWR) performance may be impacted by the presence of concomitant speech and language disorders in young children who stutter (CWS).

Method:
One hundred forty-one children (88 CWS and 53 children who do not stutter [CWNS]) participated. CWS were divided into groups based on the presence of speech sound and/or language disorder or typical speech sound production and language abilities. NWR abilities were measured using stimuli composed of one- to four-syllable nonwords.

Results:
CWS with typical speech and language and CWNS had higher accuracy scores than CWS with concomitant speech and language disorders. We found no difference in accuracy scores between CWNS and CWS with typical speech and language abilities, nor did we find differences between CWS with speech sound disorder and CWS with both speech sound and language disorders. Accuracy decreased as nonword length increased for all groups.

Conclusions:
We found that the presence of a concomitant speech and language disorder was a driving factor behind poorer NWR performance in CWS. Accuracy scores differentiated CWS with concomitant disorders from CWS with typical speech and language but not CWS with typical speech and language from CWNS. Considering the speech and language abilities of CWS helped clarify poorer NWR performance and enhances generalizability to the population that exists clinically.
Analysis and prevention of commutation failure caused by HVDC rectifier AC faults
Authors: Lin Sheng , Lei Yuqing , Liu Jian , Liu Lei 
Published: January 2022

AbstractEarlier works have reported that rectifier AC faults also can cause commutation failure during fault‐off recovery process. Whereas the occurrence of CF is merely ascribed to inverter AC faults in conventional wisdom. Note that the existing CF mitigation approaches are designed mostly by the evolution of inverter electrical quantities, which will fail to take action to CF caused by rectifier faults, posing threat to the operation of power system. Thus, the paper firstly presents the essential reasons for CF caused by rectifier ac faults, combined with the fault information transmission process and control response. It is found that DC current surge and improper control interaction are the main reasons. Accordingly, a novel current cooperative optimization (CCO) control strategy is proposed, which aimed at reducing the risk of CF caused by rectifier ac faults. Simulation results verify the correctness of the mechanism and the effectiveness of the proposed control strategy.
A scale‐sensitive heatmap representation for multi‐person pose estimation
Authors: Du Congju , Yu Han , Yu Li 
Published: January 2022

AbstractMulti‐person pose estimation is a challenging vision task that can be seriously affected by keypoint scale variation. Existing heatmap‐based approaches are devoted to reducing the effect by optimizing backbone architecture or loss functions, but the problem of an inaccurate heatmap representation with different keypoint scales still exists. A scale‐sensitive heatmap algorithm is presented to generate reasonable spatial and contextual features for the network to predict more precise coordinates, by systematically considering the standard deviation, truncated radius, and shape of Gaussian kernels. Specifically, the scale‐sensitive heatmap algorithm contains three parts: inter‐person heatmap, limited‐area heatmap, and shape‐aware heatmap. The inter‐person heatmap allocates different standard deviations for each human instance proportionally calculated by the keypoint‐based method, the limited‐area heatmap defines the truncated radius to limit the influence area of Gaussian kernels, and the shape‐aware heatmap modifies the Gaussian kernels generated by some ellipse‐shaped joints. Our scale‐sensitive heatmap algorithm outperforms the baseline by a considerable margin on the COCO and CrowdPose benchmark datasets. The code and pretrained models are available at https://github.com/ducongju/Scale‐sensitive‐Heatmap.
Complete decoupling compensation of three‐phase inverter with LCL filter in synchronous reference frame
Authors: Shi Jingkui , Huang Wenxin , Zheng Xinxin 
Published: January 2022

AbstractA decoupling control strategy of three‐phase inverter, which can realize complete decoupling of the active and reactive current in the synchronous reference frame (SRF) is proposed here. There are two coupling factors of current loop in SRF, one is time delay caused by digital control, and the other is AC filter. Dynamic time delay compensation is applied to eliminate coupling caused by the first factor. The phase of the bridge leg voltage can be predicted. The difference between it and the phase of reference voltage which takes part in pulse width modulation (PWM) is the dynamic compensation angle, which can compensate the time delay. High‐order feedforward compensation is applied to eliminate coupling caused by the second factor. Complex vector model of the LCL filter is derived and the high‐order coupling coefficients can be offset by feedforward compensation. The coupling characteristics and compensation principles are analysed in detail. The system stability is discussed. Finally, the simulation and experimental results are given to verify the theoretical analysis.
History-independent tracers
Authors: Holdship J. , Viti S. 
Published: January 2022

Context. Molecular line emission is a powerful probe of the physical conditions of astrophysical objects but can be complex to model, and it is often unclear which transitions would be the best targets for observers who wish to constrain a given parameter.
Aims. We produce a list of molecular species for which the gas history can be ignored, removing a major modelling complexity. We then determine the best of these species to observe when attempting to constrain various physical parameters.
Methods. We use a large set of chemical models with different chemical histories to determine which species have abundances at 1 Myr that are insensitive to the initial conditions. We then use radiative transfer modelling to produce the intensity of every transition of these molecules. We finally compute the mutual information between the physical parameters and all transitions and transition ratios in order to rank their usefulness in determining the value of a given parameter.
Results. We find 48 species that are insensitive to the chemical history of the gas, 23 of which have collisional data available. We produce a ranked list of all the transitions and ratios of these species using their mutual information with various gas properties. We show mutual information is an adequate measure of how well a transition can constrain a physical parameter by recovering known probes and demonstrating that random forest regression models become more accurate predictors when high-scoring features are included. Therefore, this list can be used to select target transitions for observations in order to maximize knowledge about those physical parameters.
Discovery of ammonia (9,6) masers in two high-mass star-forming regions
Authors: Yan Y. T. , Henkel C. , Menten K. M. , Gong Y. , Ott J. , Wilson T. L. , Wootten A. , Brunthaler A. , Zhang J. S. , Chen J. L. , Yang K. 
Published: January 2022

Context.Molecular maser lines are signposts of high-mass star formation, probing the excitation and kinematics of very compact regions in the close environment of young stellar objects and providing useful targets for trigonometric parallax measurements.Aims.Only a few NH3(9,6) masers are known so far, and their origin is still poorly understood. Here we aim to find new NH3(9,6) masers to provide a better observational basis for studying their role in high-mass star-forming regions.Methods.We carried out NH3(9,6) observations toward Cepheus A and G34.26+0.15 with the Effelsberg 100-meter telescope (beam size 49′′) and theKarl G. JanskyVery Large Array (JVLA; beam size about 1′′.2).Results.We discovered new NH3(9,6) masers in Cep A and G34.26+0.25, which increases the number of known high-mass star-forming regions hosting NH3(9,6) masers from five to seven. Long-term monitoring (20 months) at Effelsberg shows that the intensity of the (9,6) maser in G34.26+0.25 is decreasing, while the Cep A maser remains stable. Compared to the Effelsberg data and assuming linear variations between the epochs of observation, the JVLA data indicate no missing flux. This suggests that the NH3(9,6) emission arises from single compact emission regions that are not resolved by the interferometric measurements. As JVLA imaging shows, the NH3(9,6) emission in Cep A originates from a sub-arcsecond-sized region, slightly to the west (0′′.28 ± 0′′.10) of the peak position of the 1.36 cm continuum object, HW2. In G34.26+0.25, three NH3(9,6) maser spots are observed: one is close to the head of the cometary ultracompact H IIregion C, and the other two are emitted from a compact region to the west of the hypercompact H IIregion A.Conclusions.The newly found (9,6) masers appear to be related to outflows. The higher angular resolution of JVLA and very long baseline interferometry observations are needed to provide more accurate positions and constraints for pumping scenarios.
Interventional Bronchus Occlusion Using Amplatzer Devices – A
Promising Treatment Option for Children with Persistent Air Leak
Authors: Schütz Katharina , Happel Christoph M. , Keil Oliver , Dingemann Jens , Carlens Julia , Wetzke Martin , Müller Carsten , Köditz Harald , Griese Matthias , Reiter Karl , Schweiger-Kabesch Andrea , Backendorf Alexander , Scharff AnnaZychlinsky , Bertram Harald , Schwerk Nicolaus 
Published: January 2022

AbstractBackground: Persistent air leak (PAL) is a severe complication of secondary
spontaneous pneumothorax (SSP). Surgical interventions are usually successful
when medical treatment fails, but can be associated with significant
complications and loss of potentially recoverable lung parenchyma. Methods:
Retrospective analysis of efficacy and safety of interventional bronchus
occlusions (IBO) using Amplatzer devices (ADs) in children with PAL secondary to
SSP. Results: Six patients (four males, 4–15 years of age) underwent IBO
using ADs as treatment for PAL. Necrotizing pneumonia (NP) was the most common
cause (n=4) of PAL. Three patients were previously healthy and three
suffered from chronic lung disease. All patients required at least two chest
tubes prior to the intervention for a duration of 15–43 days and all
required oxygen or higher level of ventilatory support. In three cases, previous
surgical interventions had been performed without success. All children improved
after endobronchial intervention and we observed no associated complications.
All chest tubes were removed within 5–25 days post IBO. In patients with
PAL related to NP (n=4), occluders were removed bronchoscopically
without re-occurrence of pneumothorax after a mean of 70 days (IQR:
46.5–94). Conclusion: IBO using ADs is a safe and valuable treatment
option in children with PAL independent of disease severity and underlying
cause. A major advantage of this procedure is its less invasiveness compared to
surgery and the parenchyma- preserving approach.
Post-endoscopy Barrett’s neoplasia after a negative index endoscopy: a systematic review and proposal for definitions and performance measures in endoscopy
Authors: Desai Madhav , Lieberman David , Srinivasan Sachin , Nutalapati Venkat , Challa Abhishek , Kalgotra Pankush , Sundaram Suneha , Repici Alessandro , Hassan Cesare , Kaminski Michal F. , Sharma Prateek 
Published: January 2022

Background A high rate of neoplasia, both high grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) has been reported in Barrett’s esophagus at index endoscopy, but precise rates of post-endoscopy Barrett’s neoplasia (PEBN) are unknown.
Methods A systematic review and meta-analysis was performed examining electronic databases (inception to October 2021) for studies reporting PEBN. Consistent with the definitions of post-colonoscopy colorectal cancer proposed by the World Endoscopy Organization, we defined neoplasia (HGD/EAC) detected at index endoscopy and/or within 6 months of a negative index endoscopy as “prevalent” neoplasia, that detected after 6 months of a negative index endoscopy and prior to next surveillance interval (i. e. 3 years) as PEBN or “interval” neoplasia, and that detected after 36 months from a negative index endoscopy as “incident” neoplasia. The pooled incidence rates and proportions relative to total neoplasia were analyzed.
Results 11 studies (n = 59 795; 61 % men; mean [SD] age 62.3 [3.3] years) met the inclusion criteria. The pooled incidence rates were: prevalent neoplasia 4.5 % (95 %CI 2.2 %–8.9 %) at baseline and an additional 0.3 % (0.1 %–0.7 %) within the first 6 months, PEBN 0.52 % (0.46 %–0.58 %), and incident neoplasia 1.4 % (0.9 %–2.1 %). At 3 years from the index endoscopy, PEBN accounted for 3 % of total Barrett’s neoplasia, while prevalent neoplasia accounted for 97 %.
Conclusion Neoplasia detected at or within 6 months of index endoscopy accounts for most cases of Barrett’s neoplasia (> 90 %). PEBN accounts for ~3 % of cases and can be used for validation in future. This highlights the importance of a high quality index endoscopy in Barrett’s esophagus and the need to establish quality benchmarks to measure endoscopists’ performance.
Effectiveness and Safety of Oral Anticoagulants in the Treatment of Acute Venous Thromboembolism: A Nationwide Comparative Cohort Study in France
Authors: Bertoletti Laurent , Gusto Gaelle , Khachatryan Artak , Quignot Nadia , Chaves Jose , Moniot Audrey , Mokgokong Ruth 
Published: January 2022

AbstractIntroduction Data from clinical trials indicate that direct oral anticoagulants (DOACs) are noninferior and safer than conventional therapy (low-molecular-weight heparin followed by a vitamin K antagonist [VKA]) for treating venous thromboembolism (VTE), which includes deep vein thrombosis and pulmonary embolism (PE). This study compared the effectiveness and safety of DOACs and conventional therapy in a real-world setting.Methods This observational study used French national claims data of adult, treatment-naïve patients diagnosed with VTE (majority PE) who were hospitalized and treated for VTE with a DOAC (apixaban or rivaroxaban) or VKAs during 2013 to 2018. Patients with active cancer were excluded. After propensity score matching for each DOAC-VKA comparison, risks of bleeding, recurrent VTE, and all-cause mortality were compared at 6 months. Cox proportional hazards regression was used to estimate adjusted hazard ratios of the endpoints.Results A total of 58,137 patients were included (10,775 VKAs, 10,440 apixaban, 36,922 rivaroxaban). Propensity score-matched cohort sizes were 7,503 for apixaban and 9,179 for rivaroxaban. The hazard ratio (95% confidence interval) was significantly lower for apixaban than VKAs for bleeding requiring hospitalization (0.43 [0.32–0.59]), all-cause death (0.61 [0.51–0.74]), and first recurrent VTE (0.67 [0.52–0.85]). The hazard ratio was also significantly lower for rivaroxaban than VKAs for all-cause death (0.63 [0.53–0.74]) but not for bleeding requiring hospitalization (0.86 [0.69–1.07]) or first recurrent VTE (0.91 [0.74–1.13]).Conclusion Apixaban was associated with superior safety and effectiveness than VKAs. All-cause mortality was lower in both DOACs than VKAs. Our results support recommendations to use DOACs over VKAs for the treatment of VTE.