bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe COVID-19 with persistent respiratory failure—A retrospective cohort study in a tertiary centre in Malaysia
Authors: Wong Chee Kuan , Sia Leng Cheng , Ooi Noreen Zhi Min , Chan Wai Yee , Pang Yong-kek 
Published: November 2022

Introduction
Management of severe COVID-19 patients with persistent respiratory failure after acute phase treatment is not only challenging, but evidence for treatment is scarce, despite some authors reporting favourable clinical responses to corticosteroid therapy in histologically proven secondary organising pneumonia (OP). This study aimed to report the course of the disease, radiological pattern and clinical outcomes of severe COVID-19 patients with persistent respiratory failure.

Methods
This was a retrospective cohort study of severe COVID-19 patients who were admitted to a single tertiary centre from 1 January 2021 to 30 June 2021. The clinical data of the patients during admission and clinic follow-up, including radiological images, were traced using electronic medical records.

Results
In our cohort, the mortality rate for those with severe COVID-19 was 23.1% (173/749). Among the survivors, 46.2% (266/576) had persistent respiratory failure (PRF) after 14 days of illness. Of them, 70.3% (187/266) were followed up, and 68% (128/187) received oral corticosteroid (prednisolone) maintenance treatment. OP pattern made up the majority (81%) of the radiological pattern with a mean severity CT score of 10 (SD±3). The mean prednisolone dose was 0.68mg/kg/day with a mean treatment duration of 47 days (SD±18). About one-third of patients (67/187) had respiratory symptoms at 4 weeks (SD±3). Among 78.1% (146/187) who had a repeated CXR during follow-up, only 12 patients (8.2%, SD±3) had radiological improvement of less than 50% at 6 weeks (SD±3), with 2 of them later diagnosed as pulmonary tuberculosis. Functional assessments, such as the 6-minute walk test and the spirometry, were only performed in 52.4% and 15.5% of the patients, respectively.

Conclusion
Almost half of the patients with severe COVID-19 had PRF, with a predominant radiological OP pattern. More than two-thirds of the PRF patients required prolonged oral corticosteroid treatment. Familiarising clinicians with the disease course, radiological patterns, and potential outcomes of this group of patients may better equip them to manage their patients.
Analysis of two choir outbreaks acting in concert to characterize long- range transmission risks through SARS-CoV-2, Berlin, Germany, 2020
Authors: Reichert Felix , Stier Oliver , Hartmann Anne , Ruscher Claudia , Brinkmann Annika , Grossegesse Marica , Neumann Markus , Werber Dirk , Hausner Marius , Kunze Mareike , Weiß Bettina , Michel Janine , Nitsche Andreas , an der Heiden Matthias , Kriegel Martin , Corman Victor Max , Jones Terry Carleton , Drosten Christian , Brommann Tobias , Buchholz Udo 
Published: November 2022

Background
Superspreading events are important drivers of the SARS-CoV-2 pandemic and long-range (LR) transmission is believed to play a major role. We investigated two choir outbreaks with different attack rates (AR) to analyze the contribution of LR transmission and highlight important measures for prevention.

Methods
We conducted two retrospective cohort studies and obtained demographic, clinical, laboratory and contact data, performed SARS-CoV-2 serology, whole genome sequencing (WGS), calculated LR transmission probabilities, measured particle emissions of selected choir members, and calculated particle air concentrations and inhalation doses.

Results
We included 65 (84%) and 42 (100%) members of choirs 1 and 2, respectively, of whom 58 (89%) and 10 (24%) became cases. WGS confirmed strain identity in both choirs. Both primary cases transmitted presymptomatically. Particle emission rate when singing was 7 times higher compared to talking. In choir 1, the median concentration of primary cases’ emitted particles in the room was estimated to be 8 times higher, exposure at least 30 minutes longer and room volume smaller than in choir 2, resulting in markedly different estimated probabilities for LR transmission (mode: 90% vs. 16%, 95% CI: 80–95% vs. 6–36%). According to a risk model, the first transmission in choir 1 occurred likely after 8 minutes of singing.

Conclusions
The attack rate of the two choirs differed significantly reflecting the differences in LR transmission risks. The pooled proportion of cases due to LR transmission was substantial (81%; 55/68 cases) and was facilitated by likely highly infectious primary cases, high particle emission rates, and indoor rehearsing for an extended time. Even in large rooms, singing of an infectious person may lead to secondary infections through LR exposure within minutes. In the context of indoor gatherings without mask-wearing and waning or insufficient immunity, these results highlight the ongoing importance of non-pharmaceutical interventions wherever aerosols can accumulate.
Cyclic Composition operators on Segal-Bargmann space
Authors: Ramesh G. , Ranjan B. Sudip , Naidu D. Venku 
Published: November 2022

Abstract
We study the cyclic, supercyclic and hypercyclic properties of a composition operator C

ϕ
on the Segal-Bargmann space ℋ(ℰ), where ϕ(z) = Az + b, A is a bounded linear operator on ℰ, b ∈ ℰ with ||A|| ⩽ 1 and A*b belongs to the range of (I – A
*
A)½. Specifically, under some conditions on the symbol ϕ we show that if C

ϕ
is cyclic then A* is cyclic but the converse need not be true. We also show that if C

ϕ

* is cyclic then A is cyclic. Further we show that there is no supercyclic composition operator on the space ℋ(ℰ) for certain class of symbols ϕ.
Analytical performance of four rapid molecular testing for SARS-CoV-2
Authors: Katayama Yuki , Murai Ryosei , Sato Yuki , Moriai Mikako , Nirasawa Shinya , Saeki Masachika , Yakuwa Yuki , Fujiya Yoshihiro , Kuronuma Koji , Takahashi Satoshi 
Published: November 2022

Abstract

Objectives
Various reagents and equipment for testing SARS-CoV-2 infections have been developed, particularly rapid molecular tests based on polymerase chain reaction (PCR).

Methods
We evaluated the analytical performance of four rapid molecular tests for SARS-CoV-2. We used 56 nasopharyngeal swabs from patients with confirmed SARS-CoV-2 infection; 36 diagnosed as positive by the Ampdirect™ 2019-nCoV Detection Kit (Shimadzu assay) were considered as true-positive samples.

Results
The sensitivity of Cobas® Liat SARS-CoV-2 and Flu A/B (Cobas) was the highest among the four molecular test kits. The limit of detection was 1.49 × 10−2 copies/µL (95% confidence interval [CI]: 1.46×10−2−1.51 × 10−2 copies/µL) for Cobas; 1.43 × 10−1 copies/µL (95% CI: 8.01×10−3−2.78 × 10−1 copies/µL) for Xpert® Xpress SARS-CoV-2 test (Xpert); 2.00 × 10−1 copies/µL (95% CI: 1.95×10−1-2.05 × 10−1 copies/µL) for FilmArray Respiratory Panel v2.1 (FilmArray); and 3.33 × 10 copies/µL (95% CI: 1.93 × 10–4.72×10 copies/µL) for Smart Gene® SARS-CoV-2 (Smart gene). Cobas also had a high sensitivity (100%) compared with Shimadzu assay. The sensitivities of Xpert, FilmArray, and Smart Gene were 97.2%, 97.2%, and 75.0%, respectively. The specificity of all tests was 100%.

Conclusions
In conclusion, the four rapid SARS-CoV-2 molecular test kits have high specificity and sensitivity for detecting SARS-CoV-2. As they are easy to use, they could be a useful method for detecting SARS-CoV-2.
Construing time as blank signs in Waiting for Godot
Authors: Lin Xuejiao 
Published: November 2022

Abstract
Story time and narrative time are two interrelated issues in the research of drama. In Waiting for Godot, mere explorations in the perplexing systems of story time cannot pin down the signifieds of time, while incontiguity and quiescency of narrative time highlight the theme “Existence of time is meaningless”. The contradictory and paradoxical co-existence of story time and narrative time contributes to the construing “the void of ambiguous signifieds” and “the void of ambiguous signifiers” of time as blank signs.
The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice
Authors: Cecchini Katharine , Biasini Adriano , Yu Tianxiong , Säflund Martin , Mou Haiwei , Arif Amena , Eghbali Atiyeh , Colpan Cansu , Gainetdinov Ildar , de Rooij Dirk G , Weng Zhiping , Zamore Phillip D , Özata Deniz M 
Published: November 2022

In brief
The testis-specific transcription factor, TCFL5, expressed in pachytene spermatocytes regulates the meiotic gene expression program in collaboration with the transcription factor A-MYB.

Abstract
In male mice, the transcription factors STRA8 and MEISON initiate meiosis I. We report that STRA8/MEISON activates the transcription factors A-MYB and TCFL5, which together reprogram gene expression after spermatogonia enter into meiosis. TCFL5 promotes the transcription of genes required for meiosis, mRNA turnover, miR-34/449 production, meiotic exit, and spermiogenesis. This transcriptional architecture is conserved in rhesus macaque, suggesting TCFL5 plays a central role in meiosis and spermiogenesis in placental mammals. Tcfl5em1/em1 mutants are sterile, and spermatogenesis arrests at the mid- or late-pachytene stage of meiosis. Moreover, Tcfl5+/em1 mutants produce fewer motile sperm.
Taksir Istikhdam Wasilah Flash Card Ala Istiab Al-Mufradat Lada Thalabah Fi Al-Fashl As-Sabi Fi Al-Madrasah Al-Tsanawiyah Al-Hukumiyah 2 Padang
Authors: Angraini Lusi , Dinata Rahmat Satria 
Published: November 2022

The main problem in this research is "What is the effect of using a flash card media on the vocabulary comprehension of students in the class VII MTsN 2 Padang?". Then this research aims to know the vocabulary comprehension ability of students in the class VII MTsN 2 Padang before using flash card media, and to know the effectiveness of using flash card media on vocabulary comprehension of students in the class VII MTsN 2 Padang. The researcher used the quantitative approach by the experimental research method, and the method of data collection is the test and its tools, and the data collection method used the questions in oral and written form, and in analyzing the data with a T-test using the SPSS 20. The researcher found that the data was normally distributed and homogeneous with a significance value of > 0.05 as a requirement for the T test. The results of the research indicated that the vocabulary comprehension ability of students before using flash card means that among 30 students, 26 students were unsuccessful in the minimum scale of 80 KKM, with an average value of 62.2. Then the "T" test indicates that the result of the calculation is -38,379 that is greater than the result of the table -73,971. The result of sig (2-tailed) is 0.05 is greater than 0.000. So, the researcher concludes that Ho is rejected and Ha is accepted. So, The use of flas card is effective on vocabulary comprehension of students in the class VII MTsN 2 Padang. Keywords: Media; Flash Card; Arabic; Vocabulary
Wasiilah Google Sites Fii tadriis Maharah Al-Qira’ah As Samitha Fii Al-Madrasah Al-Aliyah Al-Hukumiyah 2 Kuantan Singingi
Authors: Aisah Aisah 
Published: November 2022

The main problem in this research is “does media Google Sites influence in learning silent reading skills on student eleventh graders of Madrasah Aliyah Negeri 2 Kuantan Singingi?”. This research is very broad, the author limits the first is the ability to silent reading skills before using media Google Sites. second is the using of media Google Sites in learning silent reading skills. third is the influence of media Google Sites in learning silent reading skills. The aims of this research is to describe ability silent reading skills before using media Goole Sites, to describe using media Google Sites, to describe influence media Google Sites in improving ability silent reading skills on student eleventh graders. The research method used is quantitative study approach that is quasi eksperimen mothod and analytic data use SPSS. The result in this research is first the ability before use media Google Sites in control class is 69, and eksperimental class is 68,33. second is the using media Google Sites in three steps. first is opening, second is mian activity its five steps observing, asking, trying, associating, and communicating, third is closing. third is the influence media Google Sites in eksperimental class is 81,66 and control class is 71,33. and based on result of Paired Sample T test, T table 3,460 bigger than T count 2,043. and sig(2-Tailed) 0,005 bigger than 0,000. its mean Median oogle Sites is influence to ability silent reading skills on student eleventh graders of Madrasah Aliyah Negeri 2 Kuantan Singingi
Tatwir Wasilah Taqwim Al-Mufradat Bistikhdam QuizWhizzer Li As-Shaf Ats-Tsamin Bi Al-Madrasah Al-Tsanawiyah Al-Islamiyah Al-Hukumiyah 1 Payakumbuh
Authors: Kurnia Emil Wahyu , Putri Neli 
Published: November 2022

Technological developments in the twenty first century have an influence on Arabic language education. Therefore, teachers must use technology based evaluation media, especially in vocabulary evaluation. The problem statement in this study is how to develop a vocabulary evaluation media using QuizWhizzer for eight grade in MTsN 1 Payakumbuh ?. This research is a development research with ADDIE model which consist of five steps. Namely : Analysis, Design, Development, Implementation, and Evaluation. However, the researcher limits the development procedure in terms of assessing media based on experts in terms of media and linguists. The results of this study are : First, Needs Analysis includes analysis of the 2013 education curriculum, student books and the forms of test used, analysis of the needs of Arabic teachers and students (they really need the development of this media). Second, Designing a vocabulary evaluation media using quizwhizzer includes writing a grid of questions and writing test questions. Third, Developing a vocabulary evaluation media includes making evaluation media in QuizWhizzer. Fourth, Implementation includes expert verification and product trial to teachers and students. The media and linguist validation result show a “Very Good” rating, which means that QuizWhizzer can be used in vocabulary evaluation for eight grade in MTsN 1 Payakumbuh without correction. Fifth, Evaluation includes product modification and final production.
The Spanish Lesbian Collective LSD: A Closer Look to Their Video-Essay Retroalimentación (1998)
Authors: Pérez Nieto Esther 
Published: November 2022

In 1993, the group LSD (Lesbianas sin duda / Lesbians without a doubt) was created in Madrid. It was a collective of artivists including Itziar Okariz Virginia Villaplana, Fefa Vila, Azucena Vietes, Marisa Maza, and Liliana Couso, among others. They met in the downtown neighbourhood of Lavapiés to publish magazines and fanzines such as Bollozine or Non Grata, dedicated to film, music, photography, and the Spanish queer art scene overall. In addition, they carried out two photographic projects that are already part of the national lesbian imaginary: Es-Cultura lesbiana and Monstruosidades. This collective, which uses artistic channels for activism, takes a model of a community that is no longer a conqueror of rights (liberalism) but rather a destroyer of all aspects of a hierarchical society.
Queer activism is located at the margins of representation, understood as “an abject margin full of monsters, in which race, class and sex are mixed, ready to come to light and destabilize the dominant discourses" (García, 2016, p. 162). Violence is no longer understood individually but within a social structure. Some of these artists later continued their careers with video actions and performances in public places, exposing their bodies and thus problematising their gender and sexual orientation, as several of them contributed to the visibility of lesbians in Spain at the turn of the century.
This article analyses the photographic and collage work of the Spanish lesbian collective LSD, taking as object of study the video essay Retroalimentación (1998), made by the LSD member Virginia Villaplana.
PERANCANGAN DAN PEMBUATAN PLAYER DENGAN KONTROL CERDAS BUATAN UNTUK PEWARNAAN KERAMIK PADA PEMBUATAN KERAMIK TRADISIONAL DI KAMPUNG WISATA KERAMIK DINOYO, MALANG
Authors: Lubis Didin Zakariya 
Published: November 2022

Penerapan IPTEKS berupa mesin Player dengan kontrol cerdas buatan berlokasi di “SN” industri salah satu UMKM kampung wisata keramik Dinoyo, kecamatan Lowokwaru, Kota Malang. Ada beberapa permasalahan yang dihadapi mitra antara lain; a) tidak adanya teknologi pewarnaan secara otomatis, pewarnaan keramik tradisional masih dilakukan secara manual, b) pewarnaan pada keramik memakan waktu yang relatif lama, karena pemutar “Player” masih menggunakan tangan, c) inkonsistensi hasil pewarnaan pada produk yang sama sehingga nilai jual produk cenderung stagnan dan tidak ada peningkatan, d) tingkat kejenuhan karyawan yang tinggi karena melakukan pekerjaan yang diulang secara terus menerus. Hal ini tentu dapat ditingkatkan jika mesin yang diusulkan dapat disetujui. Berdasarkan permasalahan tersebut maka tim pengusul memberikan inovasi teknologi berupa mesin Player. Desain dan manufacturing dari mesin Player yang diusulkan dipastikan dapat mengatasi permasalahan yang terjadi di mitra pengabdian. Dalam hal konsistensi pewarnaan dan kapasitas produksi dapat dipastikan dengan mesin yang diusulkan dapat meningkat sangat signifikan.
HYDRAULIC PRESS MACHINE SAMPAH UN-ORGANIK DALAM UPAYA PENANGGULANGAN SAMPAH UN-ORGANIK BAGI WARGA BINAAN LEMBAGA PERMASYARAKATAN 1 KOTA MALANG
Authors: Basuki Basuki 
Published: November 2022

Abstrak. Lembaga Permasyarakatan (Lapas) merupakan lembaga dibawah Direktorat Jenderal Pemasyarakatan Kementerian Hukum dan Hak Asasi Manusia yang memiliki tugas dan fungsi untuk membina dan mendidik napi supaya dapat kembali menjadi manusia yang memiliki kreatifitas, produktivitas dan berguna dalam masyarakatnya. Permasalahan yang timbul dalam lingkungan lapas antara lain: 1) Bagaimana upaya meningkatkan efektivitas pengolahan limbah sampah plastic di Lapas Lowokwaru Kota Malang melalui penerapan teknologi mesin press Plastic Hidraulik, 2) Bagaimana meningkatkan lingkungan yang bersih dan asri di Lapas Lowokwaru Kota Malang melalui pengolahan limbah sampah yang efisien. Solusi permasalahan yang dihadapi mitra antara lain: 1) Penerapan inovasi teknologi mesin Press Plastic Hidraulik yang dapat mempercepat proses pengolahan sampah un-organik, 2) peningkatan pengolahan sampah un-organik dan juga peningkatan kelestarian lingkungan lapas. Hasil dari kegiatan PKM dalam penerapan inovasi teknologi tepat guna mesin press plastic, warga binaan Lapas 1 Kota Malang lebih mudah dalam pengelolaan sampah. Hal ini dapat dilihat dengan semakin sedikitnya sampah plastic anorganik dan pengemasan plastic yang sudah siap di jual ke pengepul plastic.Kata Kunci: Hydraulic Press Mechine, Sampah Unorganiuk, Lapas
PENERAPAN INOVASI TEKNOLOGI MESIN PENGOLAH TAHU SMART ENERGI SOLAR CELL UNTUK PENGUSAHA TAHU DESA WATES, KEDIRI, JAWA TIMUR
Authors: Widiyanti Widiyanti Widiyanti 
Published: November 2022

Abstrak: UMKM penghasil tahu memiliki potensi yang besar dalam dunia pasar. Tahu merupakan makanan pokok yang banyak niminati oleh manyak masyarakat pada umumnya. Pengusaha tahu dalam proses produksi sebagian besar masih banyak yang masih dilakukan secara manual dalam proses produksi. Kemampuan yang dimiliki oleh mitra masih sangatlah sederhana dalam proses produksi. Hal ini yang menghambat dalam peningkatan proses produksi. Kegiatan Pengamdian Pada Masyarakat ini dengan mitra UMKM pengusaha tahu di Desa Wates, Kab. Kediri dengan menerapkan teknologi inovasi untuk peningkatan proses produksi tahu yang bersih dan higienis Tujuan utama dari kegiatan ini untuk menyelesaikan beberapa permasalahan yang dihadapi UMKM tahu di Desa Wates, diantaranya: a) proses produksi yang masih manual sehingga proses produksi belum secara maksimal, b) kualitas hasil produksi tahu yang masih jauh dari persaingan pasar local, c) pemasaran masih bersifat konvensional dari segi kemasan masih kesulitan untuk bersaing. Dari hasil kegiatan Pengabdian Pada Masyarakat ini proses produksi tahu mengalami peningkatan yang diikuti dengan semakin banyaknya permintaan masyarakat dalam hasil produksi tahu.Kata Kunci: Mesin Tahu, Solar Cell, Pengusaha Tahu
PELATIHAN IMPLEMENTASI ROBOTIKA MANUFAKTUR UNTUK PENGUATAN KEMAMPUAN OTOMASI INDUSTRI 4.0 ALUMNI JURUSAN TEKNIK MESIN
Authors: Marsono Marsono , Nurmalasari Riana , Yoto Yoto 
Published: November 2022

Robotika menjadi bagian penting dalam kemajuan teknologi dan peradaban dunia. Perkembangan teknologi robotika yang kian pesat telah terjadi di semua bidang kehidupan, mulai dari bidang manufaktur, industri, kesehatan, pendidikan bahkan di bidang militer. Dari perkembangan robot di industry tersebut, alumni jurusan Teknik mesin sangat urgen untuk segera mendapatkan pengetahuan ataupun kemampuan tambahan sehingga tidak ketinggalan perkembangan otomasi manufaktur terutama dalam bidang penggunaan robot manufaktur di industri. Permasalahan yang mendasar pada alumni jurusan Teknik mesin terkait dengan pengetahuan robotika yaitu belum semuanya paham terkait aplikasi pemrograman robot untuk pengerjaan produk manufaktur. Selain itu, alumni Teknik mesin masih kebingungan bagaimana mereka meningkatkan skills mereka tentang pemrograman robotika dimana banyak industri sekarang sudah menggunakan ataupun menempatkan robot pada alur industri. Oleh karenanya diperlukan pelatihan implementasi robotika manufaktur. Hasil yang dicapai pada pelaksanaan pelatihan robotika bagi para alumni adalah mampu memberikan pengetahuan dan keterampilan terkait robotika guna dimanfaatkan di dunia industri maupun di SMK tempat para alumni bekerja. Hasil pemahaman peserta pelatihan robotika dianalisis secara terpisah dan juga menyeluruh. Adapun materi yang disampaikan dalam pelatihan robotika ini yaitu konsep dasar robotika, teknik desain robot, sistem kendali robot, kinematika robot, teknik pemrograman robot dengan arduino, konsep humanoid robot di dunia industri, program arm robot, dan cara menjalankan program.
PKM PENERAPAN RECIRCULATING AQUACULTURE SYSTEM UNTUK PENGELOLAAN AIR DAN KESEHATAN IKAN BERKELANJUTAN DI POKDAKAN ROI LELE KABUPATEN MALANG
Authors: Yanuhar Uun , Wuragil Dyah Kinasih , Suryanto Heru , Mufidah Rhobithotus , Fauliza Tifa , Wardani Nezya Pramudya , Pahlefi Reval , Adhitya Dewa Sukma Trinanda , Caesar Nico Rahman 
Published: November 2022

Pemeliharaan ikan lele yang dilakukan pembudidaya di Pokdakan ROI Lele sebagian besar tidak melakukan upaya pengelolaan kualitas air seperti, filtrasi, sirkulasi maupun penggantian air (water exchange). Hal ini menyebabkan penurunan mutu air sebagai akibat dari penumpukan sisa pakan maupun feses ikan serta sisa hasil metabolisme lainnya. Lingkungan perairan merupakan suatu hal yang sangat berperan penting dalam pertumbuhan ikan lele (Clarias sp.). Oleh karena itu, perlu adanya manajemen lingkungan dan kesehatan pada pemeliharaan ikan lele (Clarias sp.). Keberhasilan suatu usaha budidaya sangat erat kaitannya dengan kondisi lingkungan yang optimum untuk kelangsungan hidup dan pertumbuhan ikan yang dipelihara. Setelah Tim PKM Mengidentifikasi pemecahan masalah yang ada, maka kegiatan pemecahan atau pengembangan yang dilakukan harus sesuai dengan kebutuhan yakni dengan menerapkan teknologi Recirculating Aquaculture System (RAS) pada kolam budidaya ikan di Pokdakan ROI Lele. Dalam penerapan sistem RAS, penggunaan filtrasi air sangat menentukan keberhasilan sirkulasi air. Pada progam PKM ini akan menggunakan Filtrasi air terdiri dari filter mekanis, filter biologi dan filter kimia. Hasil dari kegiatan pengabdian masyarakat PKM terhadap mitra adalah Pengetahuannya meningkat, keterampilannya meningkat, kapasitas produksi meningkat dan keuntungannya meningkat.