bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical efficacy of transforaminal endoscopic discectomy in the treatment of recurrent lumbar disc herniation: A single-center retrospective analysis
Authors: Xu Gang , Zhang Xuexue , Zhu Mengye , Yan Yi , Zhang Yong , Zhang Jinjin , Li Fan , Xu Mu , Zhang Daying 
Published: November 2022

Abstract
Purpose
To investigate the clinical efficacy of transforaminal endoscopic discectomy in treating recurrent lumbar disc herniation.
Methods
Clinical datal of 31 patients who were hospitalized in the Department of Pain Management, First Affiliated Hospital of Nanchang University, between 2015 and 2018 due to recurrent lumbar disc herniation were collected and analyzed retrospectively. Visual analogue scale (VAS) scores and Japanese Orthopedic Association (JOA) scores were used to assess alterations of patients’ pain intensity and nerve function, respectively. The Modified MacNab criteria were used to evaluate patients’ excellent and good rates.
Results
Compared to clinical data before surgery, there was a significant reduction in VAS scores (P < 0.01) along with a significant improvement in JOA scores (P < 0.01) at 2 years after revision surgery. The patients’ excellent and good rates were 83.87% at the 2 years after surgery.
Conclusion
The transforaminal endoscopic discectomy is safe and effective in the long term and is applicable to the treatment of recurrent lumbar disc herniation.
Effects of Zinc Oxide Nanoparticles on Growth, Carcass Characteristics and Intestinal Tight Junction Protein Gene Expression in 35-day old Broiler Chickens
Authors: Mozhiarasi V. , Karunakaran R. , Radhakrishnan L. , Raja P. , Pazhanivel N. 
Published: November 2022

Abstract

In the present study, the effect of zinc oxide nanoparticles (ZnONPs) at different concentrations (20, 40 and 60 mg/kg) in broiler chicken diet on growth, carcass characteristics and intestinal health of broiler chicks were evaluated. The ZnONPs synthesized by physical method was characterized for its nanoparticle properties and evaluated for its in vitro toxicity using different cell lines. In vivo feeding trials was conducted with 150-day-old broiler chicks randomly assigned to five dietary treatments in three replicates for the period of 35 days with ZnONPs. The results indicated that ZnONPs supplemented group showed significantly higher (p < 0.05) body weight gain and the lower feed conversion ratio (FCR) compared to control. The carcass characteristics like meat pH and dressing percentage revealed the significance differences in the ZnONPs supplemented group. The intestinal histomorphology revealed significantly higher (p < 0.05) crypt depth in ileum and villi length to crypt depth ratio in duodenum of ZnONPs supplemented group. The zinc elemental concentration in the serum found to be significantly higher and the mRNA expression of intestinal tight junction protein genes like mucin-2 and claudin-3 found to be significantly upregulated in the ZnONPs supplemented group. It could be concluded that supplementation of ZnONPs in broiler diet could improve production performance, intestinal health status and can be used as an effective feed additive in broilers.
Multi-Objective Optimization for IoT Tasks based Data Replication Placement in Fog Computing
Authors: awad ahmed , Alburaikan Alhanouf , Khalifa Hamiden Wahed , Elaziz Mohamed Abd , Abualigah Laith , M.AbdelMouty Ahmed 
Published: November 2022

Abstract
IoT applications have recently grown, quickly influencing cloud computing and Artificial Intelligence (AI) applications. Cloud computing has drawn more and more attention, particularly replication techniques and their uses. Cloud computing also provides different spaces according to usage from users and pay-for usage. It also provides flexibility in expanding or reducing the spaces according to use. Data on cloud computing is kept in several locations due to the data's growth and size. It's essential to shorten data transmission times between nodes, reduce bandwidth usage, lighten the pressure on the network, and balance the load across different regions. The expense of maintaining the system's data availability, performance, and reliability will rise as the number of replicas is increased and distributed across more locations. In this paper, we developed an Equilibrium Optimizer (EO) with Multi-Objective Optimization (MOO) to optimize a data replication placement based on IoT on fog computing. Second, we used a levy distribution to distribute a replica between nodes in cloud computing. Also, data transfer via cloud computing with a minimum bandwidth reduction. The performance of the proposed Multi-Objective Equilibrium Optimizer (MOEO) strategy was evaluated with the selection and placement of data replication using different criteria and sizes of data. To confirm the suggested algorithm's outcomes, comparisons were made between it and other algorithms. Experimental results demonstrated the superiority of the proposed algorithm over other algorithms in terms of addressing the problem of data replication placement, improving cost, and reducing data transmission time and distribution across geographically distributed sites.
Geometrical Defects in Graphene Oxide Sheets and their Response to External Load: A Molecular Dynamics Simulation
Authors: Yang Fei , Yang Zhi , Jiang Lei 
Published: November 2022

Abstract
Graphene oxide has been broadly used in seawater desalination systems owning to its controllable interlayer spacing through a defect engineering approach. These defects can provide effective migration channels for ions or molecules. However, defects weaken graphene oxide sheets, and so revealing the influence of defects on the mechanical properties of materials becomes a hot topic. In this paper, we designed different structural defects in a rectangular graphene oxide sheet, and simulated their tensile deformation process by molecular dynamics simulation. Through the analysis of the response mechanism of defects to tensile load stimulus, the influence of defects with different shape, size, quantity and distribution on the mechanical properties of graphene oxide sheets were explained systematically. The current work can provide insights into the control of mechanical properties by preparing graphene oxide defects, and promote the application of the types and effects of defects in graphene oxide in different research fields.
Characterization of microglia activation patterns in anti-LGI1 encephalitis based on TSPO PET and symptom clustering analysis
Authors: Wang Jing-guo , Ge Jing-jie , Jin Lei , Deng Bo , Tang Wei-jun , Yu Hai , Zhang Xiang , Xue Le , Zuo Chuan-tao , Chen Xiangjun 
Published: November 2022

Abstract
Purpose

TSPO PET with radioligand 18F-DPA714 is an emerging molecular imaging technique that reflects cerebral microglial activation and has been recently used in central nervous system diseases. In this study, we aimed to investigate the microglial activation pattern of anti–leucine-rich glioma-inactivated 1 (LGI1) protein autoimmune encephalitis (AIE) and to evaluate its correlation with clinical phenotypes.

Methods

Twenty patients with anti-LGI1 encephalitis from the autoimmune encephalitis cohort in Huashan hospital and ten with other AIE and non-inflammatory diseases underwent TSPO PET imaging were included in the current study. TSPO PET abnormalities in anti-LGI1 AIE were detected on a voxel basis using statistic parametric mapping analysis. Multiple correspondence analysis and hierarchical clustering were conducted for discriminate subgroups in anti-LGI1 AIE. Standardized uptake value ratios normalized to the cerebellum (SUVRc) were calculated for semiquantitative analysis of TSPO PET features between different LGI1-AIE subgroups.

Results

Increased distribution of 18F-DPA714 was identified in the bilateral hippocampus, caudate nucleus and frontal cortex in anti-LGI1 patients. Two subgroups of anti-LGI1 patients were distinguished based on the top seven common symptoms. Patients in cluster 1 had a high frequency of facio-brachial dystonic seizures than those in cluster 2 (p = 0.004), whereas patients in cluster 2 had a higher frequency of general tonic clonic seizures than those in cluster 1 (p < 0.001). Supplementary motor area and superior frontal gyrus showed higher 18F-DPA714 distribution in cluster 2 patients compared with those in cluster 1 (p = 0.024; p = 0.04,
respectively).

Conclusions

Anti-LGI1 AIE has a distinctive molecular imaging pattern presented by TSPO PET scan. Different characteristics in LGI1-AIE subgroups indicate underlying mechanisms of microglia in pathogenesis and clinical phenotypes. Further studies are required for verifying its value in clinical application.
Medical X-ray examination frequency and correlation with health economic index: a survey in east China’s Jiangsu province
Authors: Du Xiang , Wang Jin , Xu XiaoSan , Yang ChunYong , Miao Yuji , Zhu Baoli 
Published: November 2022

Abstract
Objective:To conduct the survey on medical X-ray examination, and to explore the correlation with health economic index, including GDP, numbers of bed, outpatient, medical staff by assessing the frequencies of two categories of medical X-ray examinations.
Methods: The numbers of medical radiological equipment and medical X-ray examinations in each medical institution were surveyed, and the frequencies of conventional X-ray examinations and CT scans were calculated, respectively. Their distribution characteristics were discussed through a correlation analysis between number of examination and health economic index, including GDP, beds, outpatients and medical staff.
Results: The number of conventional X-ray examinations and CT scans performed in Jiangsu in 2019 was 38,255,027 and 25,149,658, respectively. Based on the total population province wide, the frequencies of the conventional X-ray examinations and CT scans were 452 and 297 per 1,000 population, respectively. The average numbers of conventional X-ray examinations were largely identical between the three categories of institutions, whereas the numbers of CT scans showed great differences. The number and frequencies of both examinationsshowed a strong linear correlation with GDP, number of beds, outpatients and medical staff.
Conclusion: Number and frequency of radiodiagnostic examinations have seen a rapid increase in recent years, especially for CT scanning. The correlation between examination number and frequency and GDP, number of beds, outpatients, and medical staff may suggest a new strategy to extrapolate the frequency to the population in a sample survey.
Cellulose nano-fiber and fly-ash based nanohybrids: a facile and sustainable thermal insulating material
Authors: Sen Sourav , Singh Ajit , Kailasam Kamalakannan , Bera Chandan , Roy Sangita 
Published: November 2022

Abstract
Recent years have witnessed a huge surge in energy consumption by the building sector, for maintaining a pleasant atmosphere inside the building. Keeping in mind the possible energy crisis in future, the use of thermal insulators can present an extensive solution to reduce energy consumption. Due to the high demand for energy, a higher amount of coal is used in thermal power plants, which produce a huge amount of fly-ash as industrial waste that poses a serious environmental problem. In this direction, the extensive utilization of fly-ash to make useful materials is highly demanding for societal benefits. This strategy will offer a dual advantage in transforming waste to wealth coupled with potential to serve in the energy sector through effective thermal insulation. On this similar line, we have fabricated biomass-derived cellulose nano-fiber based thermal insulators and incorporated fly-ash as a reinforcer to increase the mechanical strength and fire-retardancy. Interestingly, after incorporation of fly-ash, low thermal conductivity of 0.034 W m− 1 K− 1 was achieved in the nanohybrid material with reinforcement of mechanical strength up to 2.9 MPa. Furthermore, the thermal stability was enhanced in this novel organic-inorganic nanohybrid, which may create a sustainable solution for energy related issues in future.
Primary large cell carcinoma of ureter ： a case report and review of the literature
Authors: Guo Yuan , Tang Haibin , Yang Guo , Deng Pengten , Tang Yangbin , Wu Xiaohou 
Published: November 2022

Abstract
Background： Neuroendocrine carcinoma mainly occurs in the lung and gastrointestinal tract, rarely in the urinary tract. The proportion of neuroendocrine carcinomas was less than 0.05 % [2] in urinary malignant tumors. The most common location of neuroendocrine carcinomas in the urinary system is the bladder. Fewer neuroendocrine carcinomas occur in the ureter than in the bladder.
Case presentation: A 62 years old woman presented with right ureteral obstruction due to ureteral mass. The patient began chemotherapy 2 weeks after surgery. During the 14-month follow-up, the patient received 6 courses of etoposide and Carbopol chemotherapy, and imaging examination showed no signs of recurrence. Postoperative pathological examination showed large cell neuroendocrine carcinoma of the right ureter.
Conclusions: Large cell carcinoma of ureter has a rapid course of disease and poor prognosis. Ureteral large cell carcinoma is a very rare tumor. At present, there is no specific treatment scheme. However, considering the good response of its lung counterpart to the standard chemotherapy scheme and the experience of the cure of related urinary large cell carcinoma by chemotherapy [28], we argue that platinum-based chemotherapy is effective for it and patients can benefit from it. The multimodal treatment scheme of surgery combined with platinum-based chemotherapy is the current standard scheme for the treatment of ureteral neuroendocrine carcinoma.
Late adverse events in patients with pelvic cancer after oncologic treatment -intervention and treatment effect
Authors: Iselius Sofia , Holmqvist Annica , Mikiver Rasmus , Uppugunduri Srinivas 
Published: November 2022

Abstract
Purpose
Few studies have focused on the late adverse events after oncologic treatment in pelvic cancer patients. Here, the treatment effect/interventions were studied on late side effects as GI, sexual and urinary symptoms in pelvic cancer patients who visited a highly specialized rehabilitation clinic in Linköping.
Methods
This retrospective longitudinal cohort study included 90 patients who had at least one visit at the rehabilitation clinic for late adverse events at Linköping University hospital between 2013 to 2019. The toxicity of the adverse events was analyzed by using the common terminology criteria for adverse events (CTCAE).
Results
By comparing the toxicity of symptoms between visit 1 and 2, we showed that the GI symptoms decreased with 36.6% (P = 0.013), the sexual symptoms with 18.3% (P < 0.0001) and urinary symptoms with 15.5% (P = 0.004). Patients who received bile salt sequestrant had a significant improvement in grade of GI symptoms as diarrhea/fecal incontinence at visit 2 compared to visit 1 where 91.3% were shown to have a treatment effect (P = 0.0034). The sexual symptoms (vaginal dryness/pain) significantly improved due to local estrogens between visit 1 and 2 where 58.1% had a reduction of symptoms (P = 0.0026).
Conclusion
The late side effects as GI, sexual and urinary symptoms was significantly reduced between visit 1 and 2 at the specialized rehabilitation center in Linköping. Bile salt sequestrants and local estrogens are effective treatments for side effects as diarrhea and vaginal dryness/pain.
Individual identification of inbred medaka based on characteristic dark spot patterns on the head
Authors: Morizumi Hajime , Sugimoto Naozo , Ueno Tomohiro 
Published: November 2022

Abstract
With disease progression, individual differences appear, even in an animal disease model with genetic homogeneity. Therefore, non-invasive long term observation and individual identification is desirable for late-onset diseases. To this end, the natural markings used in ecological studies are preferable to the external invasive markings used in animal husbandry and fisheries management. Here, we propose using the distribution pattern of dark spots on the head of an inbred strain of medaka, a small fish model organism with monotonous pigmentation, as biometric identifier. Long term and variation analyses show different patterns whose characteristics can be attributed to individual animals. These findings were also valid in a non-inbred medaka strain and will help individual follow-up of late-onset disease medaka models for the elucidation of the pathogenesis and drug discovery.
2-D and 3-D FE Modeling of Seismic Site-Basin Effects in Izmir-Bayrakli During October 30, 2020 M7 Samos-Aegean Sea Earthquake
Authors: Cetin Kemal Onder , Zarzour Moutasem , Cakir Elife , Tuna S. Caglar , Altun Selim 
Published: November 2022

Abstract
During Samos-Aegean Sea Earthquake Mw=7.0, Turkiye-Izmir-Bayrakli district was affected the most due to deep-soft alluvial nature and the geometry of the basin, although the district is approximately 70 km away from the epicenter of the earthquake. In this study, seismic response of the Bayrakli basin, and the role of the soil stratigraphy and geometry on the recorded amplifications and prolonging of seismic shakings are investigated by using 1-, 2- and 3-D non-linear finite element-based dynamic response analyses. The idealized large-scale basin model is calibrated and validated by using available strong ground motion records, and the results of 1-D total stress-based equivalent linear site response analyses. The assessment results were presented in the form of spectral amplification, A(T), which was defined as the ratio of 3-D (or 2-D) soil basin spectral accelerations, normalized by reference rock spectral accelerations. A(T) was decomposed into the product of two independent amplification factors, namely A1D,Rock-Soil(T) and Asoil,1D-3D or 2D(T). A1D,Rock-Soil(T) represents the spectral amplification of a 1-D soil column as compared to that of a reference rock column (site), whereas Asoil,1D-3D or 2D(T) is soil amplifications estimated by a 3-D (or 2-D) model normalized by those of a 1-D model. The numerical simulation results were summarized in the form of A(T) and Asoil,1D-3D or 2D(T) contour maps, which suggest that the 3-D basin geometry-induced amplifications reach 1.4 and 1.6 in the E-W and N-S directions of the basin.
Catalyst-free one-pot three-component synthesis of 2-iminothiazoles from nitroepoxides
Authors: Badali Elham , Halimehjani Azim Ziyaei , Habibi Azizollah 
Published: November 2022

Abstract
Nitroepoxides were introduced as efficient substrates for the one-pot three-component synthesis of 2-iminothiazoles under catalyst-free conditions. Reaction of amines, isothiocyanates, and nitroepoxides in THF at 10–15°C afforded corresponding 2-iminothiazoles in high to excellent yields. The reaction proceeds via the in situ formation of thiourea from an amine and an isothiocyanate, followed by nitroepoxide ring opening with the sulfur of thiourea, cyclization reaction, and dehydration cascade. The structures of products were confirmed by IR, NMR, HRMS analyses and X-ray crystallography.
Two formulae with nodes related to zeros of
Bessel functions for semi-infinite integrals;
Extending Gauss--Jacobi-type rules
Authors: Sugiura Hiroshi , Hasegawa Takemitsu 
Published: November 2022

Abstract
For approximating integrals ƒ∞0xαƒ(x)dx (α > −1) over a semi-infinite interval [0,∞) with a given function ƒ(x), two formulae, one of them new and another associated with an existing formula, are presented. They are constructed in a limiting process to a semi-infinite interval [0,∞] with a linear transformation for a well-known approximation method, the Gauss–Jacobi (GJ) rule and its family rules: the Gauss–Jacobi–Radau (GR) and Gauss–Jacobi–Lobatto (GL) rules on a finite interval. This procedure was used in constructing our previous limit-Clenshaw–Curtis-type formulae. The limit GJ formula (LGJ) constructed in this way uses as nodes zeros of the Bessel function Jα(x) squared after multiplied by a positive constant α and the limit GR (LGR) (and limit GL (LGL)) formula those with zeros of Jα+1(x). The LGJ formula is also shown to be derived from the formula developed by Frappier and Olivier (1993) for an integral on [0,∞). The LGR and LGL formulae give the same and new formula. We show that for a function ƒ(z) analytic on a domain in the complex plane z and satisfying some appropriate conditions, there exists a constant d > 0 such that the errors of both formulae are O(e−2d/α) as α → +0. The average of the LGJ and LGR formulae gives smaller quadrature errors than each formula. Numerical examples confirm these behaviors and show that the LGJ and LGR formulae give asymptotically the same quadrature errors of opposite sign. Consequently, the LGR formula behaves like an anti-LGJ formula in the same way as the Lobatto rule for integrals on [−1, 1] behaving like the anti-Gauss rule.
MSC Classification: 65D30
A consensus score to combine inferences from multiple centres
Authors: Haselimashhadi Hamed , Babalola Kolawole , Wilson Robert , Groza Tudor , Muñoz-Fuentes Violeta 
Published: November 2022

Abstract

Experiments in which data are collected by multiple independent resources, including multicentre data, different laboratories within the same centre or with different operators are challenging in design, data collection and inferences. This may lead to inconsistent results across the resources. In this paper, we propose a statistical solution for the problem of multi-resource consensus inferences when statistical results from different resources show variation in magnitude, directionality and significance. Our proposed method allows combining the corrected p-values, effect sizes and the total number of centres into a global consensus score. We apply this method to obtain a consensus score for data collected by the International Mouse Phenotyping Consortium (IMPC) across 11 centres. We show the application of this method to detect sexual dimorphism in haematological data and discuss the suitability of the methodology.
RNA-Seq–Based Transcriptome Analysis of Corneal Endothelial Cells Derived from Patients with Fuchs Endothelial Corneal Dystrophy
Authors: Nakagawa Tatsuya , Tokuda Yuichi , Nakano Masakazu , Komori Yuya , Hanada Naoya , Tourtas Theofilos , Schlötzer-Schrehardt Ursula , Kruse Friedrich , Tashiro Kei , Koizumi Noriko , Okumura Naoki 
Published: November 2022

Abstract
Fuchs endothelial corneal dystrophy (FECD) is the most common inherited corneal disease. Fibrillar focal excrescences called guttae and corneal edema due to corneal endothelial cell death result in progressive vision loss. Multiple genetic variants have been reported, but the pathogenesis of FECD is not fully understood. In this study, we used RNA-Seq to analyze differential gene expression in the corneal endothelium obtained from patients with FECD. Differential expression analysis of transcriptomic profiles revealed that expression of 2,366 genes (1,092 upregulated and 1,274 downregulated genes) was significantly altered in the corneal endothelium of the patients with FECD compared to healthy subjects. Gene ontology analysis demonstrated an enrichment of genes involved in extracellular matrix (ECM) organization, response to oxidative stress, and apoptotic signaling. Several pathway analyses consistently indicated the dysregulation of ECM-associated pathways. Our differential gene expression findings support the previously proposed underlying mechanisms, including oxidative stress and apoptosis of endothelial cells, as well as the phenotypic clinical FECD hallmark of ECM deposits. Further investigation focusing on differentially expressed genes related to these pathways might be beneficial for elucidating mechanisms and developing novel therapies.