bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Current and Future State of Pediatric Sepsis Definitions: An International Survey
Authors: Morin Luc , Hall Mark , de Souza Daniela , Guoping Lu , Jabornisky Roberto , Shime Nobuaki , Ranjit Suchitra , Gilholm Patricia , Nakagawa Satoshi , Zimmerman Jerry J. , Sorce Lauren R. , Argent Andrew , Kissoon Niranjan , Tissières Pierre , Watson R. Scott , Schlapbach Luregn J ,   on behalf of the Pediatric Sepsis Definition Taskforce
Published: May 2022

BACKGROUND AND OBJECTIVES
Definitions for pediatric sepsis were established in 2005 without data-driven criteria. It is unknown whether the more recent adult Sepsis-3 definitions meet the needs of providers caring for children. We aimed to explore the use and applicability of criteria to diagnose sepsis and septic shock in children across the world.

METHODS
This is an international electronic survey of clinicians distributed across international and national societies representing pediatric intensive care, emergency medicine, pediatrics, and pediatric infectious diseases. Respondents stated their preferences on a 5-point Likert scale.

RESULTS
There were 2835 survey responses analyzed, of which 48% originated from upper-middle income countries, followed by high income countries (38%) and low or lower-middle income countries (14%). Abnormal vital signs, laboratory evidence of inflammation, and microbiologic diagnoses were the criteria most used for the diagnosis of “sepsis.” The 2005 consensus definitions were perceived to be the most useful for sepsis recognition, while Sepsis-3 definitions were stated as more useful for benchmarking, disease classification, enrollment into trials, and prognostication. The World Health Organization definitions were perceived as least useful across all domains. Seventy one percent of respondents agreed that the term sepsis should be restricted to children with infection-associated organ dysfunction.

CONCLUSIONS
Clinicians around the world apply a myriad of signs, symptoms, laboratory studies, and treatment factors when diagnosing sepsis. The concept of sepsis as infection with associated organ dysfunction is broadly supported. Currently available sepsis definitions fall short of the perceived needs. Future diagnostic algorithms should be pragmatic and sensitive to the clinical settings.
A Comparative Study on Quality of Fermented Shrimp Paste (Terasi) of Pelagic Shrimp from Different Locations in Indonesia
Authors: Helmi Henny , Astuti Dea Indriani , Dungani Rudi , Aditiawati Pingkan 
Published: May 2022

This study aims to determine and compare the quality of Indonesian fermented shrimp paste (terasi) produced from pelagic marine shrimp using a traditional preservation method (fermentation, drying, and salting). The quality of fermented shrimp pastes from different locations in Indonesia (Sungsang district, South Sumatra; Toboali district, Bangka Belitung Islands; Indramayu, West Java; Tegal, Central Java; Madura, East Java; Bontang, East Kalimantan and Sumbawa, West Nusa Tenggara) was determined by evaluating its parameters (i.e., physicochemical, microbiological, and sensory). This study found that the fermented shrimp pastes quality differed among locations due to the processing method used (i.e., fermentation, salting, and drying), not the raw material characteristics, as indicated by the Principal Component Analysis (PCA). The first group (Sumatra and Sumbawa terasi samples) with a similar added salt percentage and length of fermentation resulted in similar pH, salinity, salty taste, and more preferred taste. The second group (Java and Kalimantan terasi samples) with similar lengths of first and second sun-drying resulted in similar chemical compositions such as higher protein content, lipid content, moisture content, total amino acid, and bitter taste. Terasi from Toboali prepared using Acetes japonicus with 48 h of fermentation produced the most nutritious and preferred taste by the panelists.
Deslocamento não motorizado na área central de Paranaguá (PR) Brasil: uma contribuição à mobilidade na cidade
Authors: Garcia de Faria Gislaine , Luis Tonetti Emerson , Vanhoni Jorge Felipe 
Published: May 2022

O Brasil obteve nas últimas décadas um avanço significativo das normativas sobre o planejamento urbano e ambiental. Alguns dos avanços são observados no campo do transporte e mobilidade na cidade. Paranaguá, localizada na planície costeira do Paraná, enfrenta problemas socioambientais voltados ao crescimento sem planejamento que afetam a potencialidade da mobilidade não motorizada. Nesse sentido, o objetivo da presente pesquisa foi avaliar a potencialidade do deslocamento não motorizado na área urbana do município. Todas as ruas da centralidade foram percorridas; as calçadas, as ciclovias e a arborização viária foram classificadas com qualidade alta, média ou baixa. Os dados foram lançados em bases cartográficas cedidas pela Prefeitura Municipal e utilizou-se softwares em rotinas de geoprocessamento. No geral, as calçadas e a arborização viária possuem baixa qualidade. A malha cicloviária, apesar da boa qualidade, é reduzida e atende principalmente a demanda dos trabalhadores relacionados ao Porto de Paranaguá. Conclui-se que predomina a potencialidade baixa para o deslocamento não motorizado na malha urbana do local de estudo. Os setores da funcionalidade da cidade demandam melhores condições para esse tipo de deslocamento.

PALAVRAS-CHAVE: Paranaguá. Planejamento urbano. Deslocamento não motorizado.
Repercussão do campo disciplinar do restauro arquitetônico e urbano no território brasileiro: o projeto da Estação Ferroviária de Mairinque
Authors: França Madeira Muzzi Heloísa , Paula Farah Ana 
Published: May 2022

O artigo tem por objetivo investigar a repercussão da teoria contemporânea do restauro na prática arquitetônica brasileira, analisando o caso específico do projeto de restauro ainda não executado para a Estação Ferroviária de Mairinque, lançado em concurso pelo CONDEPHAAT-SP em 2014. A metodologia de pesquisa foi dividida em duas etapas. A primeira voltou-se para o levantamento e leitura dos referenciais teórico-críticos do campo, investigando sua assimilação no território brasileiro. A segunda voltou-se para a análise técnico-operacional da intervenção proposta para a estação, diante de sua relevância cultural e documental para o país. Como resultado, foi verificado em que medida o projeto de restauro responde às demandas impostas ao edital do concurso e à deontologia do campo disciplinar. Obteve-se uma conclusão satisfatória, sendo observado um resultado projetual a par das discussões contemporâneas acerca ao campo.

PALAVRAS-CHAVE: restauro arquitetônico e urbano; patrimônio ferroviário; vertentes contemporâneas do campo disciplinar.
Enumerating Plausible Multifault Ruptures in Complex Fault Systems with Physical Constraints
Authors: Milner Kevin R. , Shaw Bruce E. , Field Edward H. 
Published: May 2022

ABSTRACT
We propose a new model for determining the set of plausible multifault ruptures in an interconnected fault system. We improve upon the rules used in the Third Uniform California Earthquake Rupture Forecast (UCERF3) to increase connectivity and the physical consistency of ruptures. We replace UCERF3’s simple azimuth change rules with new Coulomb favorability metrics and increase the maximum jump distance to 15 km. Although the UCERF3 rules were appropriate for faults with similar rakes, the Coulomb calculations used here inherently encode preferred orientations between faults with different rakes. Our new rules are designed to be insensitive to discretization details and are generally more permissive than their UCERF3 counterparts; they allow more than twice the connectivity compared with UCERF3, yet heavily penalize long ruptures that take multiple improbable jumps. The set of all possible multifault ruptures in the California fault system is nearly infinite, but our model produces a tractable set of 326,707 ruptures (a modest 29% increase over UCERF3, despite the greatly increased connectivity). Inclusion in the rupture set does not dictate that a rupture receives a significant rate in the final model; rupture rates are subsequently determined by data constraints used in an inversion. We describe the rupture building algorithm and its components in detail and provide comparisons with ruptures generated by a physics-based multicycle earthquake simulator. We find that greater than twice as many ruptures generated by the simulator violate the UCERF3 rules than violate our proposed model.
Riesgos ergonómicos de carga física y lumbalgia ocupacional en una institución de educación superior en Cartagena, Colombia
Authors: Escudero-Sabogal Irina del Rosario , Borre-Ortíz Yeis Miguel 
Published: May 2022

Se pretende identificar la relación de los riesgos ergonómicos de carga física y la aparición de lumbalgia en un grupo de trabajadores administrativos de una Institución de Educación Superior, Cartagena, Colombia, mediante un estudio descriptivo, transversal, y correlacional, realizado entre mayo 2016 y mayo de 2017. Para la recolección de la información se utilizó una encuesta sociodemográfica y el Cuestionario Nórdico de Kourinka; los resultados sociodemográficos fueron analizados con herramientas de Excel 2.5 y el análisis bivariado con SPSS 2012; la mayoría de la población pertenece al género femenino (62%), en el rango de edades de entre los 20 y 29 años); molestias osteomusculares: a nivel de cuello (51%), dorsolumbar (69%) y muñeca/mano (27%); éstas molestias han estado presentes desde los últimos 12 meses, incluso, los últimos siete días; los datos de correlación muestran una ligera asociación entre la postura sedente y la presencia de malestar muscular lumbar (r= -,343; p= ,021; IC= 95%); la investigación indica que existe una relación entre el riesgo ergonómico de carga física y lumbalgia, sin embargo, se requiere un análisis estadístico de mayor profundidad, como un estudio de causa-efecto, que explique el comportamiento y variabilidad de los datos de manera predictiva.
Propuesta de Modelo de Competitividad Sistémica de los Espacios Rurales
Authors: Vinasco-Guzmán Martha Cecilia 
Published: May 2022

El sector rural en Colombia ha sido tradicionalmente desatendido por los gobiernos locales y nacionales, evidenciado en la inequidad en la calidad de vida de los campesinos con los habitantes de áreas urbanas y que parte de la desarticulación de las propuestas en los planes de desarrollo. El objetivo es validar el Modelo de Competitividad Sistémica de los Espacios Rurales, a partir del análisis de los planes de desarrollo departamentales, para la identificación de problemáticas y oportunidades de investigación que contribuyan a solucionar las necesidades locales, regionales y nacionales, en tres categorías: político - sustentable, competitiva - productiva y ambiental - social, que luego se dividen en subcategorías orientadas desde la visión de la multiactividad de la agricultura. El modelo es dinámico, puede ser utilizado para cruzar un número muy amplio de variables y dar un panorama de la interacción de las diversas actividades, recursos, necesidades y actores involucrados en el desarrollo del campo. La metodología utilizada fue la Teoría Fundamentada, utilizando el software Atlas ti, con el que se hizo la revisión y codificación de los 33 planes de desarrollo de los departamentos de Colombia. Se evidencia en los resultados la falta de articulación de los planes y programas de los gobiernos departamentales en torno a las problemáticas del sector rural, pues no se plantean acciones particulares para el campo, lo que es crítico en aspectos como el de política de tierras, transferencia tecnológica, educación para el sector rural, mecanismos de protección social o seguridad alimentaria. El metaanálisis realizado a partir de la lectura, revisión, codificación y análisis de los planes de desarrollo, evidencia las falencias en la formulación de muchos de estos documentos, que se vuelven más críticas puesto que no contemplan acciones particulares para atender a las necesidades del campo colombiano.
Brote de enfermedad transmitida por alimentos en una población especial. Cali, Colomd transmitida por alimentos en una población especial. Cali, Colobia 2021
Authors: Osorio Merchan May Bibiana , Rizo-Tello Victor Zein , Sánchez León Edna Margarita , Arturo Quiroga Gabriela Lizeth , Prieto-Alvarado Franklyn Edwin , Gómez Ortega Luis Carlos 
Published: May 2022

Introducción: Las Enfermedades Transmitidas por Alimentos tienen un alto impacto en poblaciones confinadas y con deficientes condiciones en la preparación y distribución de alimentos. En mayo de 2021, el Sistema de Alerta Temprana del Instituto Nacional de Salud detectó un brote en Cali en una población cerrada. Objetivo: Caracterizar el brote de ETA en una población de Cali, e identificar fuente, agente y mecanismo de trasmisión con el fin de orientar las medidas de control. Métodos: Investigación de brote mediante a encuesta de consumidores y análisis con metodología de casos y controles. Se realizó análisis de inocuidad de alimentos y toma de laboratorio a alimentos cocidos. Se crearon tres definiciones de caso. Se utilizó Epi info 7.4.2 y las tres definiciones fueron contrastadas mediante OR contra alimentos, lugar de consumo, turno de consumo, edad y sexo. Resultados: Se identificaron 140 casos de 1,600 personas expuestas, tasa de ataque de 8.8%. Periodo de incubación medio de 11.7 (2.5 a 23 h). Se identificó que entre más tarde se consumían los alimentos más enfermos había. La cena, causó la mayor proporción de enfermos, con OR 8.19 IC 95%: 1.8-36.1. Conclusión: Se considera que la fuente fue la cena, el agente una toxina de E. coli y el mecanismo más probable de transmisión la contaminación cruzada. Mantener la estrategia de vigilancia comunitaria permite la detección posibles brotes, la estandarización en los procedimientos por los operadores de alimentos, así como las estrategias de prevención y un sistema de seguridad alimentaria con enfoque de riesgo.
Incidence of infections in patients with pemphigus vulgaris
Authors: Narain Upma , Kant Tejas , Kant Arun 
Published: May 2022

Background: Pemphigus is a rare, chronic autoimmune blistering disease of skin and mucous membranes. Autoimmune process and immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. Therefore, the objective of this study was to isolate and identify the pathogens in admitted patients suffering from pemphigus vulgaris.Methods: This was a retrospective observational study based on 68 diagnosed cases of pemphigus vulgaris (PV) admitted during January 1999 to April 2018 in SRN hospital, MLN medical college Prayagraj. Patients who had PV and required admission owing to development of severe symptoms were included while patients with mild symptoms were excluded from the study. These admitted patients, along with routine and radiological examination, were also examined for microbiological examinations of sputum, throat swab, blood, body fluids, skin scrapings, stool and urine when necessary.Results: Out of the 68 patients, 66.17% patients developed bacterial infections while 33.83% developed fungal infections. The prevalence of bacterial and fungal pathogens in urinary tract is 72.42% and 27.58%, pneumonitis is 29.42% and 70.58%, septicaemia is 81.82% and 18.18% and skin and soft tissue is 87.50% and 12.50% respectively. In meningitis and pulmonary tuberculosis no traces of fungi were recorded. Mortality was seen in 7.35% patients, which was due to bacterial meningitis, septicaemia and fungal pneumonitis.Conclusions: The present study clearly states that the occurrence of the disease is uncommon but secondary infections are associated with worse prognosis. Therefore, the best regimen for each type of patients should base on the extent of disease and patient’s comorbidities.
Endomyocardial fibrosis in a 7-year-old Nigerian child: a case report and review of the literature
Authors: Bassey Kevin , Okpokowuruk Frances Sam , Oghenedoro Osafugbe 
Published: May 2022

<p>Endomyocardial fibrosis (EMF) is a poorly-understood idiopathic disorder characterized by the development of restrictive cardiomyopathy. It is a disorder of the tropics and subtropics and was once the second commonest cause of acquired heart disease in Nigeria. Its diagnosis is often made when the disease is advanced and the prognosis is invariably poor at this stage. Reports of EMF have become increasingly rare in recent years and it is frequently misdiagnosed. This report seeks to highlight EMF as a still present and potentially important cause of heart failure in Nigerian children. A 7-year-old male referred to the pediatric cardiology clinic with complaints of abdominal and facial swelling, with no difficulty in breathing and exercise intolerance. Examination revealed a classic “egg-on-stick” appearance. Apex was not displaced and heart sounds were distant. Liver was enlarged but non tender and there was demonstrable ascites. A 2D echocardiography showed massive right atrial enlargement with severe tricuspid regurgitation and fibrosis within the right ventricular cavity which was small. There was a moderate-sized pericardial effusion. Electrocardiogram showed right atrial enlargement with low-voltage complexes. Full blood count showed eosinophilia (20% total white blood cell count). Total serum protein and albumin were reduced. EMF, though increasingly rare, remains an important cause of childhood cardiac morbidity and mortality. A high index of suspicion is critical as the prognosis remains poor.</p><p> </p>
Assessing the Nutrient Status of Soil and Water Bodies in Palayapatti Areas, Thanjavur District of Tamil Nadu (India)
Authors: Selvaraj S. 
Published: May 2022

Background: Thanjavur is a cauvery delta zone for paddy growing area of Tamil Nadu. The current study aiming with understanding about chemical properties and nutrient status of soils of selected area and assessing quality of water bodies. Methods: The study was conducted during 2018-19 at Palayappatti and its surrounding villages in Thanjavur district of Tamil Nadu to find out the nutrient status of soil and water. Fifty representative soil samples and ten water samples collected with the objectives of analyzing chemical properties of soil and assessing water quality in Palayapatti and its surrounding villages of Thanjavur district. Result: The collected soil and water samples varied with different chemical and physical properties. Soils were slightly acidic to slightly alkaline, normal EC and low organic carbon, low to medium content of nitrogen, phosphorus and potassium, low to medium content of calcium, magnesium and sulphur. Water samples were slightly acidic to moderately alkaline pH, medium to high salt content, moderate amount of carbonate and bicarbonate content. The soil and water bodies of this land having medium range of nutrients and also improvement is need in water quality.
Effect of Leptin and IGF-I Supplementation on in vitro Maturation and Expression of Apoptotic Genes in Goat Oocytes
Authors: Quadri Saleema Ahmedi , Shukla Satya Nidhi , Singh Ajit Pratap , Sarkhel Bikash Chandra 
Published: May 2022

Background: The quality of gametes is a crucial factor for the successful development of an embryo. The potential of oocyte development is acquired during oogenesis by many changes at the molecular and cellular levels. The present study explores the effect of leptin and IGF-I supplementation on in vitro oocyte maturation and the expression of apoptotic genes in matured goat oocytes. Methods: In vitro maturation of abattoir-derived oocytes was in maturation media having supplements as the group I (control), group II (leptin 20 ng/ml) and group III (IGF-I 100 ng/ml). From these oocytes, RNA was isolated and expressions of apoptotic genes were studied. Result: There was no significant difference found between cumulus expansion and also in nuclear maturation in groups I, II, III. The relative expression of BAX gene was 0.65 fold lower in group II and 0.42 fold lower in group III as compared to group I whereas relative expression of Mcl-1 gene was 2.55 fold higher in group II and 0.31 fold lower in group III as compared to group I.
​​Selecting Stable Chickpea Genotypes under Rainfed Cultivation using GGE Biplot Analysis
Authors: Srivastava A.K. , Mondal B. , Jha U.C. , Singh Archana , Biradar Revanappa S. , Praween Nagmi , Singh Nandan , Dixit G.P. , Kumar Yogesh 
Published: May 2022

Background: Large environmental influence has been observed on grain yield in rainfed chickpea resulting in higher yield instability. Besides per se performance, stability of chickpea genotypes is a key trait for assured yield under rainfed cultivation. The present study evaluates chickpea advanced breeding lines for stability of grain yield and its components. Methods: A set of 27 chickpea (Cicer arietinum L.) advanced breeding lines and three check varieties (JAKI 9218, JG 16, RSG 888) were evaluated for phenological and yield performance under three different environments under rainfed cultivation during 2019-20. The data was subjected to ANOVA and GGE Biplot analysis. Result: The first two principal components of the GGE Biplot explained about 80.13% of the total variation in multi-environment trial. The which won where/what biplot indicated that the genotype IPC17-78 performed well at Bhopal and Kanpur location followed by IPC15-12, IPC17-04 and IPC17-35. At Dharwad genotype IPC19-226 performed well followed by IPC19-220, IPC17-53, IPC19-222 and IPC18-63. Based on Mean vs Stability function of GGE Biplot analysis, chickpea genotype IPC17-369 was the most stable and high yielding genotype followed by IPC17-78 and IPC17-53. Genotypes IPC17-35 and IPC17-54 were more stable but had lesser yield potential. In the “Discrimitiveness vs representativeness” biplot, all the environments plotted at far distance from biplot origin indicating that they were all able to discriminate between genotypes; however, Kanpur and Bhopal were the most discriminating locations.
Analisis kestabilan lereng low wall Pit UCE di PT Jorong Barutama Grestone
Authors: Purba Pranajaya , Hakim Romla Noor Noor , Mustofa Adip 
Published: May 2022

PT Jorong Barutama Greston merupakan salah satu perusahaan pertambangan batubara. Dalam menjalankan kegiatan operasi produksi, perusahaan menghadapi masalah mengenai kestabilan lereng pada area lereng low wall. Ketidakstabilan lereng ini berpotensi menimbulkan longsor yang akan memberikan dampak yang signifikan dalam kegiatan penambangan. Selain menghambat kegiatan produksi, longsor juga dapat sewaktu waktu menimbukan resiko kecelakaan pada pekerja. Kondisi lereng aktual dilapangan menunjukkan ketidakstabilan lereng dimana terbentuknya tension crack dan adanya pergerakan pada area lereng low wall.Kondisi ketidakstabilan pada lereng ini memunculkan asumsi bahwa FK lereng low wall < 1. Maka dilakukan analisis kestabilan lereng menggunakan perangkat lunak Rocscience Slide v6.0 yang bertujuan untuk mengetahui keselarasan hasil analisis dengan kondisi lereng aktual dilapangan. Metode yang digunakan adalah metode Mogenstern-Prince, dengan bidang kelongsoran diperkirakan adalah busur (circular), ketinggian muka air tanah berdasarkan hasil pengukuran piezometer, dan parameter awal yang digunakan merupakan kuat geser puncak (peak shear strength). Hasil analisis menunjukkan nilai FK lereng lowwall > 1,7 yang dimana tidak selaras dengan kondisi aktual dilapangan. Maka dilakukan koreksi dengan menggunakan parameter kuat geser yang divariasikan dari nilai kuat geser puncak (peak shear strength) hingga nilai kuat geser sisa (residual shear strength). Hasil koreksi menunjukkan bahwa nilai kuat geser pada lereng low wall merupakan nilai kuat geser sisa (residual shear strength) dengan nilai FK terkecil = 0,943.