bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Relative Paleointensity (RPI)-Calibrated Age Model for the Corinth Syn-rift Sequence at IODP Hole M0079A (Gulf of Corinth, Greece)
Authors: Maffione Marco , Herrero-Bervera Emilio 
Published: March 2022

The Corinth basin (Greece) is a young continental rift that recorded cyclic basin paleoenvironment variations (i.e., marine to lacustrine) caused by glacio-eustatic sea level fluctuations during its initial connection to the global oceans. The Corinth syn-rift sequence offers therefore a unique opportunity to determine the timing and modality of connection of young rifts to the global oceans, and investigate how sediment supply change during this extremely dynamic stage of their evolution. Here we use magnetostratigraphic and relative paleointensity (RPI) constraints from 885 discrete samples from International Ocean Discovery Program (IODP) Hole M0079A to generate an unprecedented high-resolution (∼15kyr) age model for the youngest part of the Corinth’s offshore syn-rift sequence. Our RPI-calibrated age model spans the last ∼850 kyr and reveals that initial connection of the Corinth basin to the Mediterranean Sea occurred at ∼530 ky, more recently than previously thought and after a short-lived marine incursion at ∼740 kyr. Accumulation rates calculated from our age model indicate two significant changes in sediment supply at 530 (from 74 to 156 cm/kyr on average) and 70 ka (from 156 to 258 cm/kyr on average), interpreted as due to increased local fault activity in the southern margin of the Corinth basin. Sedimentation rates also display a short-term variation indicating a lower sediment supply (98 cm/kyr on average) during interglacial periods and a higher input (156 cm/kyr on average) during glacial periods. We conclude that long-term variations of sediment supply in young rifts connecting to the global oceans are predominantly controlled by local tectonics (i.e., new depocenters formation), while short-term variations may be driven by global climate (i.e., increased erosion aided by fewer vegetation during glacial periods). Grain size of the Corinth syn-rift sequence shows a weak correlation with glacial cycles too (i.e., coarser sediments during interglacials), but we suggest this to be controlled by the hydrodynamics of the basin (i.e., stronger bottom currents when the basin was connected to the Mediterranean Sea during interglacial periods).
Probabilistic Volcanic Hazard Assessment for National Park Infrastructure Proximal to Taranaki Volcano (New Zealand)
Authors: Mead Stuart , Procter Jonathan , Bebbington Mark , Rodriguez-Gomez Cecilia 
Published: March 2022

Hazard assessment for infrastructure proximal to a volcanic vent raises issues that are often not present, or not as severe in hazard assessments for more distal infrastructure. Proximal regions are subject to a greater number of hazardous phenomena, and variability in impact intensity increases with the hazard magnitude. To probabilistically quantify volcanic hazard to infrastructure, multiple volcanic hazards and their effects on exposed elements need to be considered. Compared to single-hazard assessments, multi-hazard assessments increase the size and complexity of determining hazard occurrence and magnitude, typically introducing additional uncertainties in the quantification of risk. A location-centred approach, focusing on key locations rather than key hazards, can simplify the problem to one requiring identification of hazards with the potential to affect the location, followed by assessment of the probability of these hazards and their triggering eruptions. The location-centred approach is more compatible to multi-source hazards and allows for different hazard estimation methodologies to be applied as appropriate for the infrastructure type. We present a probabilistic quantification of volcanic hazard using this location centred approach for infrastructure within Te Papakura o Taranaki National Park, New Zealand. The impact to proposed park infrastructure from volcanic activity (originating from Mt. Taranaki) is quantified using a probability chain to provide a structured approach to integrate differing hazard estimation methods with eruption probability estimates within asset lifetimes.This location-centered approach provides quantitative estimates for volcanic hazards that significantly improve volcanic hazard estimates for infrastructure proximal to the Taranaki summit vent. Volcanic mass flows, predominantly pyroclastic surges or block and ash flows, are most likely (probability &gt;0.8) to affect walking tracks if an eruption occurs. The probability of one or more eruption(s) in the next 50 years is estimated at 0.35–0.38. This use of probability chains and a location centered assessment demonstrates a technique that can be applied to proximal hazard assessments globally.
Sediment Particle Size Composition in the Riparian Zone of the Three Gorges Reservoir
Authors: Liu Dan , Nie Qingyu , Xiong Chunmei , Yu Zhuolin , Lv Yunan , Zhang Shuai , Cheng Shuxun , Lan Bo , Kumar Amit , Yu Zhiguo , Lin Junjie 
Published: March 2022

The riparian zone is a transitional zone of terrestrial ecosystems and aquatic ecosystems, which is one of the main sources of reservoir sediment and pollutants. The sediment loss has an increasing trend in the riparian zone of the Three Gorges Reservoir (TGR), which was closely related to sediment particle size composition change in the riparian zone, but its distribution and factors are still unclear. Hydrological conditions, sediment particle size composition and vegetation properties in the riparian zone were investigated in 3 mainstream and 8 tributary sections along the Yangtze River within the TGR across 450 km. On the one hand, both sediment sand content and median particle size (D50) showed a horizontal raising trend from the upstream to the dam region of the TGR at the mainstream and tributary sites. On the other hand, compared to the upper-middle mainstream and the tributaries of Longxi, Wu, Longxi, Pengxi, Daning, Tongzi rivers, the D50 was much higher in the lower altitudes of the riparian zone in the tributaries of Wubu, Ruxi, and Xiangxi and the mainstream in the lower reaches of the Yangtze River. With the raising of the riparian zone slope, D50 decreased in the mainstream riparian zone sites, while increased in the tributary riparian zone sites (p &lt; 0.05). Besides, D50 was 2.3 times higher in the south aspect relative to the north aspect of the riparian zone in the TGR. No significant relationship was found between root biomass of a local dominate species-Cynodon Dactylon (Linn.) and D50. Hydrological and geographical variables could predict 64%–67% of the D50 variance, and thus could be regarded as the main predictor of D50 in the riparian zone of the TGR.
Association Among the Gut Microbiome, the Serum Metabolomic Profile and RNA m6A Methylation in Sepsis-Associated Encephalopathy
Authors: Wang Hui , Wang Qing , Chen Jingjing , Chen Cunrong 
Published: March 2022

Objective: To investigate the relationship among the gut microbiome, serum metabolomic profile and RNA m6A methylation in patients with sepsis-associated encephalopathy (SAE), 16S rDNA technology, metabolomics and gene expression validation were applied.Methods: Serum and feces were collected from patients with and without (SAE group and non-SAE group, respectively, n = 20). The expression of serum markers and IL-6 was detected by enzyme-linked immunosorbent assay (ELISA), and blood clinical indicators were detected using a double antibody sandwich immunochemiluminescence method. The expression of RNA m6A regulator were checked by Q-RTPCR. The gut microbiome was analyzed by 16S rDNA sequencing and the metabolite profile was revealed by liquid chromatography-mass spectrometry (LC-MS/MS).Results: In the SAE group, the IL-6, ICAM-5 and METTL3 levels were significantly more than those in the non-SAE group, while the FTO levels were significantly decreased in the SAE group. The diversity was decreased in the SAE gut microbiome, as characterized by a profound increase in commensals of the Acinetobacter, Methanobrevibacter, and Syner-01 genera, a decrease in [Eubacterium]_hallii_group, while depletion of opportunistic organisms of the Anaerofilum, Catenibacterium, and Senegalimassilia genera were observed in both groups. The abundance of Acinetobacter was positively correlated with the expression of METTL3. The changes between the intestinal flora and the metabolite profile showed a significant correlation. Sphingorhabdus was negatively correlated with 2-ketobutyric acid, 9-decenoic acid, and l-leucine, and positively correlated with Glycyl-Valine [Eubacterium]_hallii_group was positively correlated with 2-methoxy-3-methylpyazine, acetaminophen, and synephrine acetonide.Conclusion: The gut microbiota diversity was decreased. The serum metabolites and expression of RNA m6A regulators in PBMC were significantly changed in the SAE group compared to the non-SAE group. The results revealed that serum and fecal biomarkers could be used for SAE screening.
Identification of Potential Core Genes for the Rupture of Intracranial Aneurysms by a Bioinformatics Analysis
Authors: Lin Yuan , Ma Hai-Ying , Wang Yi , He Jiang , Liu Heng-Jian 
Published: March 2022

Background: Previous studies, using autopsy and angiography, have shown that 3.6–6% of the population have intracranial aneurysms, and the rupture of aneurysm can lead to brain dysfunction or even death in patients.Methods: To explore potential preventional target genes for the ruptured of aneurysm, we analyze three gene expression datasets (GSE13353, GSE15629 and GSE54083) derived from the GEO database. We confirm DEGs associated with the unrupture of aneurysms by R package. DAVID version provides functional classification and annotation analyses of associated genes, including GO and KEGG pathway. PPI of these DEGs is analyzed based on the string database and visualized by Cytoscape software. DEGs are verified by qRT-PCR using samples isolated from the patients.Results: 249 overlapping DEGs, including 96 up-regulated genes and 153 down-regulated genes are screened using the Venn diagram webtool. The GO term and KEGG pathways analysis results indicate that these DEGs are mainly enriched in protein phosphorylation, apoptotic process and inflammatory response in the BP term and focal adhesion, thyroid hormone signaling pathway, ErbB signaling pathway, cytokine-cytokine receptor interaction and some disease processes in the KEGG pathways. 6 candidates are confirmed by Cytoscape software and qRT-PCR, including APP, JUN, GSK3B, ErbB2, PPBP and THBS1.Conclusions: Our data and previous studies show that ErbB2 and THBS1 are crucial to prevent aneurysm rupture, while APP, JUN, GSK3B and PPBP performs the opposite role, and further experiments are needed to verify these findings.
Sex as a Potential Moderator for Baclofen Response in the Treatment of Alcohol Dependence
Authors: Morley Kirsten C. , Louie Eva , Hurzeler Tristan , Baillie Andrew , Dore Glenys , Phung Nghi , Haber Paul S. 
Published: March 2022

Background and AimsRecent studies indicate that sex may moderate the response to baclofen in the treatment of alcohol use disorder (AUD). We conducted a secondary analysis of a double-blind randomized controlled trial, Baclofen in the treatment of Alcohol Liver Disease (BacALD), to examine the moderating role of sex on treatment response to baclofen in reducing alcohol consumption.MethodsAlcohol-dependent patients (n = 104 including 74 men and 30 women) were treated for 12 weeks with baclofen (30 mg/day or 75 mg) or placebo. Predefined primary outcomes included time to lapse (any drinking) and relapse (≥ 5 drinks per day in men and ≥ 4drinks per day in women). Other outcomes included drinks per drinking day, the number of heavy drinking days, and percentage of days abstinent. We also examined the frequency of adverse events with an exploratory dose–response analysis.ResultsThere was a main effect of baclofen for days to first lapse for women (Log Rank: χ2 = 6.23, p = 0.01, d = 0.49) but not for men (Log Rank: χ2 = 2.48, p = 0.12, d = 0.22) and a marginal effect of baclofen for days to first relapse for women (Log Rank: χ2 = 3.15, p = 0.08, d = 0.27) but not for men (Log Rank: χ2 = 2.03, p = 0.16, d = 0.17). There were no significant effects of sex on the frequency of adverse events reported for the combined-dose or between-dose analysis (all p &gt; 0.44).ConclusionBaclofen significantly delayed the time to lapse for women but not male participants. These findings provide some support for the hypothesis that sex may be a potential moderator of baclofen response in the treatment of AUD.Trial Registrationhttps://clinicaltrials.gov/ct2/show/NCT01711125, identifier: NCT01711125.
Impact of the SARS-CoV-2 Delta Variant on the Psychological States and Health-Related Quality of Life in Patients With Crohn’s Disease
Authors: Li Jiajia , Sun Yunyun , Hu Xiaolin , Zhao Tiantian , Yao Guanghuai , Xiao Weiming , Ding Yanbing , Hou Sicong , Wang Mei 
Published: March 2022

BackgroundSince the outbreak of the coronavirus disease 2019 (COVID-19) pandemic first reported in Wuhan, China, several research on the psychological impact of the pandemic on patients with Crohn’s disease (CD) have been conducted. However, with the progression of the global pandemic and the emergence of the SARS-CoV-2 B.1.617.2 (Delta) variant, follow-up studies need to be performed to monitor the alterations of psychological status and health-related quality of life (HRQoL) among CD patients.AimsWe aimed to evaluate the impact of the SARS-CoV-2 Delta variant on the mental health and life quality among the CD population and tried to explore potent risk factors.MethodsThis observational study included 153 CD patients who responded to our pre-designed self-reported questionnaire. Demographic, clinical, and psychological information were collected and analyzed.ResultsQuite a number of CD patients were confronted with different levels of anxiety and depression, with incidence of 28.10 and 31.37% for anxiety and depression, respectively. Compared with non-pandemic circumstances, the life quality of CD patients due to the present situation was more often compromised. Isolation [odds ratio (OR): 4.71, P = 0.007] was verified as a risk factor for anxiety while use of telemedicine could help relieve anxiety (OR: 0.22, P &lt; 0.001). Worsening of symptoms (OR: 4.92, P = 0.006), isolation (OR: 5.75, P = 0.005), and drug withdrawn (OR: 2.66, P = 0.026) were identified to be independent factors for developing depression. Likewise, use of telemedicine (OR: 0.13, P &lt; 0.001) was negatively related to depression. Considering life quality, vaccination (OR: 3.07, P = 0.021) together with no medication (OR: 7.73, P = 0.010) was relevant to better life quality while worsening of symptoms (OR: 0.09, P = 0.034) were an independent risk factor for impaired life quality.ConclusionMany CD patients suffered from symptoms of anxiety and depression and impaired life quality during the COVID-19 pandemic. Those in isolation or with worsening of symptoms and drug withdrawn were more prone to experience psychological stress. Individualized management such as drug delivery and telemedicine should be promoted to maintain control of mental health and life quality during the pandemic.
How Do Family Physicians Perceive Their Role in Providing Pre-exposure Prophylaxis for HIV Prevention?–An Online Qualitative Study in Flanders, Belgium
Authors: Vanhamel Jef , Reyniers Thijs , Wouters Edwin , van Olmen Josefien , Vanbaelen Thibaut , Nöstlinger Christiana , Mieghem Heleen Van , Landeghem Ella Van , Rotsaert Anke , Laga Marie , Vuylsteke Bea 
Published: March 2022

Introduction:In Belgium, the provision of pre-exposure prophylaxis (PrEP) for HIV prevention is centralized in specialized HIV clinics. Engaging family physicians in PrEP care could help scale-up its delivery and reach underserved populations. The objective of this study was to gain insight into family physicians' self-perceived roles in providing PrEP.MethodsWe conducted 16 online group discussions with a total of 105 Flemish family physicians, between November 2020 and February 2021. A brief online questionnaire assessed their socio-demographics and experience with sexual health. We analyzed verbatim transcribed data using a grounded theory approach.ResultsDespite limited awareness and experience, participants reported a high willingness to be more actively involved in PrEP care. Four potential roles for the family physician in PrEP care were identified: acting as low-threshold entry point for advice; opportunistic case finding of PrEP candidates; initiating appropriate care for PrEP-eligible clients; and ensuring high-quality follow-up care for PrEP users. Participants framed each of these roles within their current activities and responsibilities as primary care providers. Yet, participants differed in their views on the concrete operationalization of these roles, and in the extent of their involvement in PrEP. Particular challenges were a lack of experience with antiretrovirals, perceived limited exposure to clients at high HIV risk, and a lack of expertise and resources to conduct time-intensive risk assessments and counseling related to PrEP.ConclusionBelgian family physicians demonstrated a keen willingness to be involved in PrEP care, but had differing views on the practical implementation into their practices. Providing tailored training on sexual health and PrEP, and investing in collaboration between primary and secondary care, could optimize the integration of PrEP in the primary care practice.
Central Nervous System Cryptococcosis in Patients With Sarcoidosis: Comparison With Non-sarcoidosis Patients and Review of Potential Pathophysiological Mechanisms
Authors: Prevel Renaud , Guillotin Vivien , Imbert Sébastien , Blanco Patrick , Delhaes Laurence , Duffau Pierre 
Published: March 2022

IntroductionCryptococcusspp. infection of the central nervous system (CINS) is a devastating opportunistic infection that was historically described in patients with acquired immunodeficiency syndrome (AIDS).Cryptococcusspp. infections are also associated with sarcoidosis; the impairment of cell-mediated immunity and long-term corticosteroid therapy being evoked to explain this association. Nevertheless, this assertion is debated and the underlying pathophysiological mechanisms are still unknown. The aims of this study were (i) to describe the clinical and biological presentation, treatments, and outcomes of CINS patients with and without sarcoidosis and (ii) to review the pathophysiological evidence underlying this clinical association.Patients and MethodsEvery patient with positive cerebrospinal fluid (CSF) cryptococcal antigen testing, India ink preparation, and/or culture from January 2015 to December 2020 at a tertiary university hospital were included, and patients with sarcoidosis were compared with non-sarcoidosis patients. Quantitative variables are presented as mean ± SD and are compared using the Mann-Whitney Wilcoxon rank-sum test. Categorical variables are expressed as the number of patients (percentage) and compared using the χ2or Fisher's tests.ResultsDuring the study period, 16 patients experienced CINS, of whom 5 (31%) were associated with sarcoidosis. CINS symptoms, biological, and CSF features were similar between CINS patients with and without sarcoidosis except regarding CD4 cells percentages and CD4/CD8 ratio that was higher in those with sarcoidosis (47 ± 12 vs. 22 ± 18,p= 0.02 and 2.24 ± 1.42 vs. 0.83 ± 1.10,p= 0.03, respectively). CINS patients with sarcoidosis had less often positive blood antigen testing than those without sarcoidosis (2/5 vs. 11/11,p= 0.02). CINS patients with and without sarcoidosis were treated with similar drugs, but patients with sarcoidosis had a shorter length of treatment. CD4 cell levels do not seem to explain the association between sarcoidosis and cryptococcosis.ConclusionSarcoidosis was the most frequently associated condition with CINS in this study. CINS patients associated with sarcoidosis had overall similar clinical and biological presentation than CINS patients associated with other conditions but exhibited a lower rate of positive blood cryptococcal antigen testing and higher CD4/CD8 T cells ratio. Pathophysiological mechanisms underlying this association remain poorly understood but B-1 cell deficiency or lack of IgM could be a part of the explanation. Another plausible mechanism is the presence of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in a subset of patients with sarcoidosis, which could impair macrophage phagocytic function. Further studies are strongly needed to better understand those mechanisms and to identify at-risk patients.
Changing Professional Behaviors in the Digital World Using the Medical Education e-Professionalism (MEeP) Framework—A Mixed Methods Multicentre Study
Authors: Guraya Shaista Salman , Yusoff Muhamad Saiful Bahri , Rashid-Doubell Fiza , Harkin Denis W. , Al-Amad Suhail H. , Fredericks Salim , Halabi Mouhammad Omar O. , Abdullah Natasya , Moussa Hatem , Mallah Saad Imad Yousef , Sefen Jessica Atef Nassef , AlKoheji Heba Khalid A. Rahman Mohamed Ishaq , Althawadi Manal Ebrahim Ali , Alabbasi Lana Abdulsalam , Nor Mohd Zarawi Mat , Reguig Farida , Guraya Salman Yousuf 
Published: March 2022

Background:There is increasing evidence on the exponential use of technology-based social media in medical field that has led to a proliferation of unprofessional behaviors in digital realm. Educating, training, and changing the behaviors of healthcare professionals are essential elements to restrain the rising unprofessional incidents. Therefore, this research was designed to determine the impact of an interventional workshop on the medical and dental students in improving their professional behaviors in the digital world using the newly developed medical Education e-Professionalism (MEeP) framework.MethodsWe adopted the Theory of Planned Behavior (TPB) as a benchmark reference which explores constructs intertwined with the mission-based MEeP framework; values (whistleblowing-raising concerns), behaviors (being responsible in the digital world) and identity (reflective practice in the digital world). A multicentre 3-phased mixed-method study was conducted using a pre-workshop survey, an online interventional workshop, and a post-workshop survey. SPSS and NVivo were the tools used for the data analysis.ResultsA total of 130 students registered for workshop out of which 120 completed the pre-workshop survey, 62 joined the workshop and 59 completed the workshop and post-workshop survey. From the whistleblowing – raising concern perspective, we found that attitudes and perceived behavioral control had a significant relationship. While for responsible in digital world category, attitude and perceived behavioral control had a significant bearing on the intentions. Third, for reflective practice, attitude and subjective norms significantly enhanced the intention of participants. A multi layered thematic analysis yielded four overarching themes of attitudes, subjective norms, perceived behavioral control and intentions. Most students showed positive attitudes of being reflective, self-directed, and humane. Students realized the subjective norms had made them conscientious, self-aware and conformative. While perceived behavioural control manifested as identity and Intentions were heavily reliant on self-actualization.ConclusionOur mixed method study found that the interventional workshop using MEeP framework significantly improved attitudes, subjective norms, perceived behavioral control, and intentions. This study provides valuable evidence of MEeP framework evaluation using the theoretical underpinning of TPB by reporting positive changes in professional values, behaviors, and identities of undergraduate medical and dental students.