bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability of Hepatitis E Virus After Drying on Different Surfaces
Authors: Wolff Alexander , Günther Taras , Johne Reimar 
Published: January 2022

AbstractThe hepatitis E virus (HEV) causes acute and chronic hepatitis in humans. The zoonotic HEV genotype 3 is mainly transmitted by consumption of contaminated food produced from infected animals. However, transmission via contaminated surfaces has also to be considered. Here, the genotype 3c strain 47832c was dried on steel, wood, plastics and ceramics, stored at 23 °C or 3 °C for up to 8 weeks and remaining infectivity was titrated on cell culture. During the drying process, only a mean 0.2 log10 decrease of HEV infectivity was observed. At 23 °C, remaining infectious virus was detected until week 4 on most surfaces, but HEV was completely inactivated (> 4 log10 decrease) after 8 weeks. At 3 °C, HEV was detectable up to 8 weeks on most surfaces, with an average 2.3 log10 decrease. HEV showed the highest stability on plastics, which was lower on ceramics and steel, and lowest on wood. The addition of bovine serum albumin mimicking high protein load had only a slight stabilizing effect. In conclusion, HEV shows a high stability against drying and subsequent storage on different surfaces. Strict application of hygienic measures during food production is therefore crucial in order to prevent HEV persistence on surfaces and subsequent cross-contamination.
Shelters for aquaculture of Octopus sinensis: preferences for gap width and horizontal versus vertical plates
Authors: Suzumura Yuta , Matsubara Keiji , Morii Shunzo , Abe Masami , Gleadall Ian G. , Nishikawa Masazumi , Katayama Ayu , Nishitani Goh , Okawara Yu , Kimura Riku , Akiyama Nobuhiko 
Published: January 2022

AbstractIt is difficult to keep a large number of cultured octopuses together in the same holding tank due to the high incidence of cannibalism. Appropriate shelters within which the octopuses can more readily avoid their peers are expected to ameliorate this problem. Shelters can be constructed from square plates assembled with appropriate spacing (gap) between them. The purpose of this study was to ascertain the optimum plate orientation and gap width between plates for shelters to maximize the accommodation of octopuses. It was found that the number of shelter occupants increased with the number of gaps available, such that more than half of the individuals in the experimental tank used the same shelter simultaneously. Octopuses tested singly to determine preferences for shelters placed vertically or horizontally preferred the vertical arrangement. Octopuses of more than 300 g tested singly in aquaria given shelters with different gap widths (20–100 mm) were found to not enter shelters with gap widths of 20 or 40 mm. It is concluded that octopus shelters constructed from square vertical plates spaced with gap widths suitable for octopuses are a useful contribution towards maximizing the number of octopuses that can be maintained in culture conditions.
Is the Sardinian Blue Zone the New Shangri-La for mental health? Evidence on depressive symptoms and its correlates in late adult life span
Authors: Ruiu Marilena , Carta Valeria , Deiana Clara , Fastame Maria Chiara 
Published: January 2022

Abstract
Background
An area of extraordinary longevity (i.e., Sardinian Blue Zone) characterized by a very high prevalence of long-lived successful agers has been validated in Sardinia, an Italian island located in the Mediterranean Sea.

Aims
This study was primarily aimed at examining whether dietary habits (intake of vegetables and fruit, animal-derived proteins, and carbohydrates-rich food), time spent on hobbies, subjective physical health, and socio-cultural context (Sardinian Blue Zone vs. another Sardinian rural area) predicted self-reported depressive symptoms in older adults recruited in the Sardinian Blue Zone and another Sardinian rural area not being characterized by a higher prevalence of long-lived individuals.

Methods
Three hundred and eighteen community-dwellers, age 65 years and older, 188 females and 130 males (Mage = 79.1 years, SD = 6.9 years) were recruited from the Sardinian Blue Zone and another Sardinian rural area. Each participant individually completed a battery of instruments to assess lifestyle, food habits, perceived physical health, and depressive symptoms through the CES-D inventory.

Results
Significant associations were found between depressive signs, perceived physical health, time spent gardening, proteins, and carbohydrates intake, respectively. Approximately 17% of the variance in the CES-D condition was predicted by socio-cultural context, perceived physical health, and gardening. Participants recruited in the Sardinian Blue Zone spent more time gardening and self-reported better physical health.

Conclusions
current results suggest that a socio-cultural context where people age well (i.e., the Sardinian Blue Zone), and a healthy and physically active lifestyle are crucial for promoting well-being in late adulthood.
Digital twin-driven smart supply chain
Authors: Wang Lu , Deng Tianhu , Shen Zuo-Jun Max , Hu Hao , Qi Yongzhi 
Published: January 2022

AbstractToday’s supply chain is becoming complex and fragile. Hence, supply chain managers need to create and unlock the value of the smart supply chain. A smart supply chain requires connectivity, visibility, and agility, and it needs be integrated and intelligent. The digital twin (DT) concept satisfies these requirements. Therefore, we propose creating a DT-driven supply chain (DTSC) as an innovative and integrated solution for the smart supply chain. We provide background information to explain the DT concept and to demonstrate the method for building a DTSC by using the DT concept. We discuss three research opportunities in building a DTSC, including supply chain modeling, real-time supply chain optimization, and data usage in supply chain collaboration. Finally, we highlight a motivating case from JD.COM, China’s largest retailer by revenue, in applying the DTSC platform to address supply chain network reconfiguration challenges during the COVID-19 pandemic.
Body (of) Knowledge: Women, the Body, and Dance in Postwar Japan
Authors: Baldock Alice Bethany Susan 
Published: January 2022

AbstractThis study examines the revolution of ideas surrounding the body in 1950s Japan from the perspective of two women dancers, Noh dancer Tsumura Kimiko (1902–74) and butoh dancer Motofuji Akiko (1928–2003). By contrasting one mid-twentieth-century view—that the postwar era offered a chance to “liberate” individual bodies—with the backdrop of continued control over bodies exercised by large institutions, I first show that this perceived rupture was not as stark as it initially appears. Moreover, I show how Tsumura and Motofuji rejected popular ideas about the body's purpose to forge their own. This allowed them to critique and confront the issues that popular views presented, particularly for disabled or gendered bodies. These issues involved increasing urbanization and the treatment of bodies based upon their desirability. This article argues that Tsumura's and Motofuji's conceptions of “body” challenged gender norms and presented new ideas about how to live.
Vascular abnormalities – a true cause of pulsatile tinnitus?
Authors: Walters H , Chung N , Arullendran P 
Published: January 2022

AbstractObjectivePulsatile tinnitus can be a symptom of vascular pathology. However, many of these pathologies present as incidental findings on scanning for unrelated symptoms. This study investigated whether the pathologies attributed to pulsatile tinnitus could instead be considered incidental findings.MethodsThis retrospective study evaluated imaging results of 272 pulsatile tinnitus cases for clinically relevant pathologies, and examined correlations between the site of symptoms and the imaging findings.ResultsOf 272 patients, 238 (88 per cent) had normal scans, 17 (6 per cent) had clinically insignificant incidental findings, and 18 (7 per cent) had findings requiring further investigation or intervention; regarding these latter 18 patients, findings for 8 patients (42 per cent) did not correlate with the symptomatic side. The rates of intracranial aneurysm and arteriovenous malformation in the pulsatile tinnitus group were comparable to those in normal populations.ConclusionThe comparable rates of vascular abnormalities within the symptomatic pulsatile tinnitus group, plus clinically relevant findings contralateral to symptoms, suggest that vascular pathologies could be incidental findings rather than causes of pulsatile tinnitus. Evaluation is recommended of the effectiveness of the new National Institute for Health and Care Excellence guidelines for pulsatile tinnitus investigation.
A paediatric case of myopericarditis post-COVID-19 mRNA vaccine
Authors: Türe Mehmet , Akın Alper , Demir Muhammed , Akay Cihan 
Published: January 2022

AbstractMyopericarditis is a condition, which primarily involves the pericardium, with minimal myocardial involvement. In myopericarditis, chest pain, elevated cardiac enzymes, and electrocardiographic changes occur. Although COVID-19 mRNA vaccines significantly contribute to preventing the COVID-19 disease, rarely myocarditis and/or pericarditis may develop due to these vaccines. We present a previously healthy 14-year-old male patient who developed myopericarditis after receiving the second dose of the COVID-19 mRNA vaccine.
Safety and efficacy of early augmentation with repetitive transcranial magnetic stimulation in the treatment of drug-free patients with obsessive–compulsive disorder
Authors: Joshi Mohita , Kar Sujita Kumar , Dalal Pronob K. 
Published: January 2022

AbstractBackgroundObsessive–compulsive disorder (OCD) is a chronic psychiatric disorder that results in significant disability and substantial compromise in the quality of life. Until now, the role of repetitive transcranial magnetic stimulation (rTMS) has been primarily explored in individuals with treatment-resistant OCD. In this study, we investigated the safety and efficacy of rTMS as an early augmentation strategy in drug-free patients with OCD.MethodsThis is a randomized double-blind, placebo-controlled study that involved the administration of a total of 20 sessions of rTMS (active/sham) to drug-naïve OCD patients using a standard protocol (1-Hz; 20 trains [80 pulses/train]; 1600 pulses per session at 100% resting motor threshold) at supplementary motor area. All patients (active and sham) were started on escitalopram 10 mg/d, which was subsequently increased to 20 mg/d after 10 days.ResultsOut of the 24 patients, 13 received active and 11 received sham rTMS. At the end of rTMS therapy, there was a substantial reduction (P = .001) in total Yale-Brown Obsessive–Compulsive Scale, obsessions (P = .030) and compulsions (P = .001) between the groups. Only few patients (N = 8) reported mild side effect with rTMS, local pain, and headache being the commonest. The study revealed large effect size (Cohen’s d = 1.6) of rTMS as an early augmentation strategy in drug-free patients of OCD.ConclusionsrTMS is a safe and effective early augmentation strategy in the management of OCD. Larger randomized controlled trials are required to establish the therapeutic role of rTMS as early augmentation in OCD.
A SUBSTRUCTURAL GENTZEN CALCULUS FOR ORTHOMODULAR QUANTUM LOGIC
Authors: FAZIO DAVIDE , LEDDA ANTONIO , PAOLI FRANCESCO , ST. JOHN GAVIN 
Published: January 2022

AbstractWe introduce a sequent system which is Gentzen algebraisable with orthomodular lattices as equivalent algebraic semantics, and therefore can be viewed as a calculus for orthomodular quantum logic. Its sequents are pairs of non-associative structures, formed via a structural connective whose algebraic interpretation is the Sasaki product on the left-hand side and its De Morgan dual on the right-hand side. It is a substructural calculus, because some of the standard structural sequent rules are restricted—by lifting all such restrictions, one recovers a calculus for classical logic.
Supporting value sensitivity in the humanitarian use of drones through an ethics assessment framework
Authors: Wang Ning , Christen Markus , Hunt Matthew , Biller-Andorno Nikola 
Published: January 2022

AbstractThe current humanitarian use of drones is focused on two applications: disaster mapping and medical supply delivery. In response to the growing interest in drone deployment in the aid sector, we sought to develop a resource to support value sensitivity in humanitarian drone activities. Following a bottom-up approach encompassing a comprehensive literature review, two empirical studies, a review of guidance documents, and consultations with experts, this work illuminates the nature and scope of ethical challenges encountered by humanitarian organizations embarking upon innovation programmes. The Framework for the Ethics Assessment of Humanitarian Drones (FEAHD) identifies five values and five key questions related to ethical considerations along the decision chain of humanitarian drone activities. It fills a gap between high-level, principle-based guidance related to humanitarian innovation, and detailed operation-oriented checklists for projects involving the use of drones. In this way, the FEAHD contributes to support value sensitivity in the humanitarian use of drones.
Seismic Velocity Variations at Different Depths Reveal the Dynamic Evolution Associated With the 2018 Kilauea Eruption
Authors: Liu Zhiqiang , Liang Chuntao , Huang Huixuan , Wang Chaoliang , Cao Feihuang 
Published: January 2022

AbstractAdvances in noise‐based velocity change measurements have revealed anomalies before volcanic eruptions. Still, it is difficult to assign them to a certain depth based on the traditional coda wave method. Here we used volcanic tremor (1–2.5 s) and oceanic noise (3 and 3.5 s) as passive sources to calculate the Rayleigh wave velocity changes associated with the 2018 Kilauea eruption. Our simulation show that the velocity decreased at least by 5% at 1–2 km depth beneath the East Rift zone in the co‐eruption time. Before the eruption, we observed a decrease (1%) at the same depth, whereas, at the depths of 0–1 and 2–8 km, the velocity increased by 0.2%–1%. Combined with microearthquakes, The Global Positioning System data, and numerical simulation, our observations suggest that magma intrusion may open the magma dike at 1–2 km depth but induce higher compressive stress (about 3.6–14.4 MPa) in the surrounding areas.
River Organic Carbon Fluxes Modulated by Hydrodynamic Sorting of Particulate Organic Matter
Authors: Repasch Marisa , Scheingross Joel S. , Hovius Niels , Vieth‐Hillebrand Andrea , Mueller Carsten W. , Höschen Carmen , Szupiany Ricardo N. , Sachse Dirk 
Published: January 2022

AbstractRivers regulate the global carbon cycle by transferring particulate organic carbon (POC) from terrestrial landscapes to marine sedimentary basins, but the processes controlling the amount and composition of fluvially exported POC are poorly understood. We propose that hydrodynamic sorting processes modify POC fluxes during fluvial transit. We test this hypothesis by studying POC transported along a ∼1,200 km reach of the Rio Bermejo, Argentina. Nanoscale secondary ion mass spectrometry revealed that POC was either fine, mineral‐associated organic matter, or coarse discrete organic particles. Mineral‐associated POC is more resistant to oxidation and has a lower particle settling velocity than discrete POC. Consequently, hydraulic sorting and downstream fining amplify the proportion of fine, mineral‐associated POC from ∼55% to ∼78% over 1,220 km of downstream transit. This suggests that mineral‐associated POC has a greater probability of export and preservation in marine basins than plant detritus, which may be oxidized to CO2 during transit.
Monitoring Fracture Saturation With Internal Seismic Sources and Twin Neural Networks
Authors: Nolte D. D. , Pyrak‐Nolte L. J. 
Published: January 2022

AbstractSeismic coda‐wave analysis is a well‐developed method for detecting subtle physical changes in complex media by measuring arrival times in the late‐arriving energy from multiply scattered or reflected waves. However, a challenge arises when multiply scattered waves are not sufficiently separated in time from the direct arrivals to provide a clear coda wave train. Additional complications for monitoring changes in fracture systems arise when the signals originate from unsynchronized internal sources, such as natural or induced seismicity, from acoustic emission, or from transportable intra‐fracture sources (chattering dust), that generate uncontrolled signals that vary in arrival time, amplitude and frequency content. Here, we use a twin neural network (TNN also known as a Siamese neural network) for dimensionality reduction to analyze signals from chattering dust to classify the fluid saturation state of a synthetic fracture system. The TNN with shared weights generates a low‐dimensional representation of the data input by minimizing contrastive loss, serving as the input to a multiclass classifier that accurately classifies whether multiple fractures in a fracture system are fully saturated or partially saturated, or whether a change in saturation has occurred in different fractures in the system. These results show that information buried in unresolved codas from uncontrolled sources can be extracted using machine learning to monitor the evolution of fracture systems caused by physical and chemical processes even when the scattered and direct wave fields overlap.
A coordinate-based meta-analysis of white matter alterations in patients with alcohol use disorder
Authors: Spindler Carolin , Mallien Louisa , Trautmann Sebastian , Alexander Nina , Muehlhan Markus 
Published: January 2022

AbstractIntroduction: Besides the commonly described gray matter (GM) deficits, there is growing evidence of significant white matter (WM) alterations in patients with alcohol use disorder (AUD). WM changes can be assessed using volumetric and diffusive magnetic resonance imaging methods, such as voxel-based morphometry (VBM) and diffusion tensor imaging (DTI). The aim of the present meta-analysis is to investigate the spatial convergence of the reported findings on WM alterations in AUD. Methods: Systematic literature search on PubMed and further databases revealed 18 studies eligible for inclusion, entailing a total of 462 AUD patients and 416 healthy controls (up to January 18, 2021). All studies that had used either VBM or DTI whole-brain analyzing methods and reported results as peak-coordinates in standard reference space were considered for inclusion. We excluded studies using approaches non-concordant with recent guidelines for neuroimaging meta-analyses and studies investigating patient groups with Korsakoff syndrome or other comorbid substance use disorders (except tobacco). Results: Anatomical likelihood estimation (ALE) revealed four significant clusters of convergent macro- and microstructural WM alterations in AUD patients that were assigned to the genu and body of the corpus callosum, anterior and posterior cingulum, fornix, and the right posterior limb of the internal capsule. Discussion: The changes in WM could to some extent explain the deteriorations in motor, cognitive, affective, and perceptual functions seen in AUD. Future studies are needed to clarify how WM alterations vary over the course of the disorder and to what extent they are reversible with prolonged abstinence.
Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment
Authors: Baranowsky Anke , Jahn Denise , Jiang Shan , Yorgan Timur , Ludewig Peter , Appelt Jessika , Albrecht Kai K. , Otto Ellen , Knapstein Paul , Donat Antonia , Winneberger Jack , Rosenthal Lana , Köhli Paul , Erdmann Cordula , Fuchs Melanie , Frosch Karl-Heinz , Tsitsilonis Serafeim , Amling Michael , Schinke Thorsten , Keller Johannes 
Published: January 2022

AbstractIntermittent injections of parathyroid hormone (iPTH) are applied clinically to stimulate bone formation by osteoblasts, although continuous elevation of parathyroid hormone (PTH) primarily results in increased bone resorption. Here, we identifiedCalca, encoding the sepsis biomarker procalcitonin (ProCT), as a novel target gene of PTH in murine osteoblasts that inhibits osteoclast formation. During iPTH treatment, mice lacking ProCT develop increased bone resorption with excessive osteoclast formation in both the long bones and axial skeleton. Mechanistically, ProCT inhibits the expression of key mediators involved in the recruitment of macrophages, representing osteoclast precursors. Accordingly, ProCT arrests macrophage migration and causes inhibition of early but not late osteoclastogenesis. In conclusion, our results reveal a potential role of osteoblast-derived ProCT in the bone microenvironment that is required to limit bone resorption during iPTH.
A novel 1-bp deletion variant in DAG1 in Japanese familial asymptomatic hyper-CK-emia
Authors: Fan Luoming , Miura Shiroh , Shimojo Tomofumi , Sugino Hirotoshi , Fujioka Ryuta , Shibata Hiroki 
Published: January 2022

AbstractAsymptomatic hyper-CK-emia (ASCK) is characterized by persistent elevation of creatine kinase (CK) in serum without any neurological symptoms. We ascertained a two-generation family of ASCK patients without clear neurological abnormalities except for the high levels of serum CK (810.5 ± 522.4 U/L). We identified a novel 1-bp deletion variant in the DAG1 gene shared by the patients in the family (NM_001177639: exon 3: c.930delC:p.R311Gfs*70). The variant causes premature termination of translation at codon 477, resulting in a protein product completely devoid of the essential DAG1 domain. Since ASCK has been associated with DAG1 in only one case carrying compound heterozygous missense variants, our new finding of a novel 1-bp deletion revealed the previously unknown dominant effect of DAG1 on ASCK.
Native lattice strain induced structural earthquake in sodium layered oxide cathodes
Authors: Xu Gui-Liang , Liu Xiang , Zhou Xinwei , Zhao Chen , Hwang Inhui , Daali Amine , Yang Zhenzhen , Ren Yang , Sun Cheng-Jun , Chen Zonghai , Liu Yuzi , Amine Khalil 
Published: January 2022

AbstractHigh-voltage operation is essential for the energy and power densities of battery cathode materials, but its stabilization remains a universal challenge. To date, the degradation origin has been mostly attributed to cycling-initiated structural deformation while the effect of native crystallographic defects induced during the sophisticated synthesis process has been significantly overlooked. Here, using in situ synchrotron X-ray probes and advanced transmission electron microscopy to probe the solid-state synthesis and charge/discharge process of sodium layered oxide cathodes, we reveal that quenching-induced native lattice strain plays an overwhelming role in the catastrophic capacity degradation of sodium layered cathodes, which runs counter to conventional perception—phase transition and cathode interfacial reactions. We observe that the spontaneous relaxation of native lattice strain is responsible for the structural earthquake (e.g., dislocation, stacking faults and fragmentation) of sodium layered cathodes during cycling, which is unexpectedly not regulated by the voltage window but is strongly coupled with charge/discharge temperature and rate. Our findings resolve the controversial understanding on the degradation origin of cathode materials and highlight the importance of eliminating intrinsic crystallographic defects to guarantee superior cycling stability at high voltages.