bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coxsackievirus B3 elicits a sex-specific CD8+T cell response in female mice
Authors: Dhalech Adeeba H. , Condotta Stephanie A. , Corn Caleb , Richer Martin J. , Robinson Christopher M. 
Published: August 2022

AbstractSex is a significant contributor to the outcome of human infections. Males are frequently more susceptible to viral, bacterial, and fungal infections, which is often attributed to a weaker immune response. In contrast, a heightened immune response in females enables better pathogen elimination but leaves females more predisposed to autoimmune diseases. Unfortunately, the underlying basis for sex-specific immune responses remains poorly understood. Here, we show a sex-specific difference in the CD8+T cell response to an enteric virus, Coxsackievirus B3 (CVB3). We found that CVB3 induced expansion of CD8+T cells in female mice but not in male mice. CVB3 also increased the proportion and number of CD11ahiCD62LloCD8+T cells in female mice, indicative of activation. Further, this response was independent of the inoculation route and type I interferon. Using a recombinant CVB3 virus expressing a model CD8+T cell epitope, we found that the expansion of CD8+T cells is viral-specific and not due to bystander activation. These data demonstrate that CVB3 induces a sex-dependent CD8+T cell response and highlight the importance of sex-specific immune responses to viral pathogens.
Human iPSC Derived Enamel Organoid Guided by Single-Cell Atlas of Human Tooth Development
Authors: Alghadeer A , Hanson-Drury S , Ehnes D , Zhao YT , Patni AP , O’Day D , Spurrell CH , Gogate AA , Phal A , Zhang H , Devi A , Wang Y , Starita L , Doherty D , Glass I , Shendure J , Baker D , Regier MC , Mathieu J , Ruohola-Baker H 
Published: August 2022

AbstractTooth enamel secreted by ameloblasts is the hardest material in the human body, acting as a shield protecting the teeth. However, the enamel is gradually damaged or partially lost in over 90% of adults and cannot be regenerated due to a lack of ameloblasts in erupted teeth. Here we use sci-RNA-seq to establish a spatiotemporal single-cell atlas for the developing human tooth and identify regulatory mechanisms controlling the differentiation process of human ameloblasts. We reveal key signaling pathways involved between the support cells and ameloblasts during fetal development and recapitulate those findings in a novel human ameloblast in vitro differentiation from iPSCs. We furthermore develop a mineralizing enamel organ-like 3D organoid system. These studies pave the way for future regenerative dentistry and therapies toward genetic diseases affecting enamel formation.
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps
Authors: Remesh Soumya G. , Merz Gregory E. , Brilot Axel F. , Chio Un Seng , Rizo Alexandrea N. , Pospiech Thomas H. , Lui Irene , Laurie Mathew T. , Glasgow Jeff , Le Chau Q. , Zhang Yun , Diwanji Devan , Hernandez Evelyn , Lopez Jocelyne , Pawar Komal Ishwar , Pourmal Sergei , Smith Amber M. , Zhou Fengbo ,   QCRG Structural Biology Consortium, DeRisi Joseph , Kortemme Tanja , Rosenberg Oren S. , Glasgow Anum , Leung Kevin K. , Wells James A. , Verba Kliment A. 
Published: August 2022

SummaryThe SARS-CoV-2 Omicron variant, with 15 mutations in Spike receptor binding domain (Spike-RBD), renders virtually all clinical monoclonal antibodies against WT SARS-CoV-2 ineffective. We recently engineered the SARS-CoV-2 host entry receptor, ACE2, to tightly bind WT-Spike-RBD and prevent viral entry into host cells (“receptor traps”). Here we determine cryo-EM structures of our receptor traps in complex with full length Spike. We develop a multi-model pipeline combining Rosetta protein modeling software and cryo-EM to allow interface energy calculations even at limited resolution and identify interface side chains that allow for high affinity interactions between our ACE2 receptor traps and Spike-RBD. Our structural analysis provides a mechanistic rationale for the high affinity (0.53 - 4.2nM) binding of our ACE2 receptor traps to Omicron-RBD confirmed with biolayer interferometry measurements. Finally, we show that ACE2 receptor traps potently neutralize Omicron- and Delta-pseudotyped viruses, providing alternative therapeutic routes to combat this evolving virus.
Sustaining multilinguality: case studies of two multilingual digital libraries
Authors: Wu Anping , Chen Jiangping 
Published: August 2022

Purpose
This study aims to understand the technical and operational challenges encountered by multilingual digital libraries and their strategies to solve problems in sustaining multilinguality services for digital libraries.

Design/methodology/approach
Using the multiple-case method, this study investigated two digital libraries that have sustained multilinguality for over a decade: the World Digital Library and the Digital Library of the Caribbean.

Findings
This study identified eight factors that contributed to the success of the two multilingual digital libraries and eight technical and operational challenges they have faced. A framework for digital libraries to sustain multilinguality is proposed. This framework illustrates the challenges and strategies to address the challenges in 11 aspects: creation, leadership, collaboration, content, metadata, translation, funding, technology, preservation, staffing and copyright.

Research limitations/implications
This study focused on two multilingual digital libraries administered in the USA, though they do not fully represent multilingual digital libraries in the USA. Therefore, the findings from the study may not apply to multilingual digital libraries the USA or other countries. As on-site interviews of both digital libraries were conducted at the beginning of 2019, the timeframe of this study is up to that date.

Practical implications
With more users worldwide seeking information online, more digital libraries will be providing multilingual services. This study provides guidelines to digital library developers and archivists for building and sustaining their digital libraries or archives. The experience and lessons learned from these two digital libraries may also help to better understand challenges and use effective strategies in building and sustaining multilinguality.

Social implications
The users and communities of digital libraries will be able to learn the benefits and challenges as related to building and sustaining digital library services. These services always need support to better serve their users and communities.

Originality/value
As the first multiple-case research that investigates in-depth challenges and approaches of digital libraries in sustaining multilinguality, this study presents a general picture of how the two digital libraries have succeeded in sustaining multilinguality. Theoretically, the study enriches the literature by providing a more comprehensive sustainability framework for multilinguality. This framework specifies possible aspects to consider for gaining sustainability of multilingual digital libraries and offers useful guidelines and insights for the digital library community to build multilingual services.
Theorizing the impact of network characteristics on multitier sustainable supply chain governance: a power perspective
Authors: Gruchmann Tim 
Published: August 2022

PurposeWhile the literature on multitier supply chain management traditionally assumes that first-tier suppliers belong to the visible proportion of the supply base, intermediaries might limit focal firms' visible horizon already at this stage. High power asymmetries promoting centrality and complexity in the supply network are seen as a particular root cause that limits the impact of governance mechanisms for sustainability. To map the space for governance mechanisms in a network-sensitive context more comprehensively, the study analyzes supply network characteristics from a power perspective.Design/methodology/approachThis research is conceptual. To better understand power imbalances and mutual dependencies from network centrality and complexity, network configurations were constructed drawing on resource dependence theory. These configurations allow deducing the impact of (non-)mediated governance mechanisms for a sustainable development in the supply network. An agenda to stimulate future empirical and model-based research is accordingly presented.FindingsThe research shows that those networks with densely interconnected first-tier suppliers promote network centrality and complexity, leading to an inverted U-shape relationship between the focal firm's exertion of coercive power and the sustainability performance in the supply network. The findings allow a more comprehensive theoretical grounding for mapping governance approaches in a network-sensitive context and provide insights on how to avoid negative effects from power asymmetries.Practical implicationsThe findings suggest the need for accompanying, indirect governance mechanisms already at the stage of first-tier suppliers based on non-mediated forms of power, such as referent power, also promoting disintermediation. Purchasing companies may also consider using digital platform technologies that foster disintermediation, such as blockchain technology.Originality/valueBy studying intermediaries from a power and network perspective, the conceptualization adds to the discussion on governance in multitier sustainable supply chain networks in various industries. Furthermore, it contributes to the increasing efforts of middle-range theorizing in logistics and supply chain management. The results partially challenge previous assumptions on the moderating role of specific network characteristics.
From work meaningfulness to playful work design: the role of epistemic curiosity and perceived Leader's autonomous support
Authors: Khan Muhammad Awais 
Published: August 2022

PurposeBuilding on the self-determination theory (SDT), the purpose of this study is to empirically examine the influence of work meaningfulness (WM) on employees' involvement in playful work design (PWD) in the context of software development firms in Pakistan.Design/methodology/approachFor the present study, a two-wave employee survey (online questionnaire) was used for data collection. The data were collected through an adopted questionnaire from employees working in software development firms in Pakistan. structural equation modeling and Hayes Process Macro of SPSS were used to analyze data collected from 305 respondents.FindingsThe findings of this study show that work meaningfulness and epistemic curiosity (EC) positively and significantly influence employee playful work design strategies. Moreover, the relationship between work meaningfulness and playful work design was partially mediated by employee epistemic curiosity. This mediating role of epistemic curiosity is strengthened by the presence of the perceived leader's autonomous support (LAS).Research limitations/implicationsEmployees improve their personal work experience through playful work design. Theoretically, this study contributes to the body of knowledge on the factors (work meaningfulness, epistemic curiosity and leader's autonomous support) that can influence employees' self-determination to design fun and competition into their work. This study contributes to the theory by introducing the antecedents (work meaningfulness and epistemic curiosity), of employee playful work design and explores the role of epistemic curiosity as a mediator and the leader's autonomous support as a moderator through SDT perspective.Practical implicationsFor practitioners, this study pinpoints that software development firms can consider improving employees' perception of work meaningfulness, which can lead them to become epistemically curious to proactively design their work experience for their psychological need fulfillment, well-being and better functioning. Moreover, leader's autonomous support can support involvement in playful work design.Originality/valueThe current study is the first investigation in the Asian context to study the antecedents of playful work design and a critical boundary condition. This study extends the literature on the antecedents of employee playful work design and explores the role of epistemic curiosity as a mediator and the leader's autonomous support as a moderator specifically through a self-determination perspective.
Value relevance of accounting earnings and cash flows in a transition economy: the case of Serbia
Authors: Čupić Milan , Todorović Mirjana , Benković Slađana 
Published: August 2022

PurposeThe purpose of the study is to investigate the association of earnings and cash flows with stock prices and returns, and the impact of regulatory changes on the value relevance of accounting numbers.Design/methodology/approachThe authors examine a sample of non-financial firms listed on the Belgrade Stock Exchange from 2005 to 2018 and use three regression models – price, return and differenced.FindingsThe authors find evidence that accounting earnings are more value relevant than cash flows. The authors also find negative relation of earnings changes with stock returns and argue that this is due to the lower persistence of negative earnings levels and changes. Finally, the authors find that the value relevance of accounting information in Serbia increases after the improvements in capital market regulation.Research limitations/implicationsGiven the empirical focus on a transition economy, the widespread applicability of the study is limited. The findings, however, call for more research on transition economies to better understand the functioning of capital markets and the way information from financial statements is incorporated into stock prices.Practical implicationsThe results imply that policymakers in transition economies should improve the accounting and capital market regulation to provide better investor protection and to improve the capital market conditions.Originality/valueThe authors add to knowledge about the value relevance of accounting information in emerging and transition economies. The results could be of interest to standard setters in their efforts to better understand and improve the quality of accounting information in emerging and transition economies.
Reductive mechanisms for unwanted intrusive thoughts: exploring affectivity in clinical and non-clinical samples
Authors: Omoregie Jesse , Carson Jerome 
Published: August 2022

PurposeUnwanted intrusive thoughts (UITs) are a major public health concern (Nocket al., 2008; Bentumet al., 2017), and they are key to the development of a variety of dysregulated behaviours (Jungmannet al., 2016; Bergenet al., 2012). Thus, this study aims to investigate reductive mechanisms for unwanted intrusive thoughts by analysing aspects of affectivity in clinical and non-clinical samples.Design/methodology/approachQuantitative means of data collection and analysis were used to explore UITs and affectivity. In total, 530 adults took part in this study (236 males, 253 females and 15 transgenders). Participants consisted of clinical (N= 168) and non-clinical samples (N= 336) who completed the Midlife in the United States sense of control scale (Lachman and Weaver, 1998), 20-item neuroticism scale (Goldberg, 1999), self-compassion scale (Neff, 2003a), flourishing scale (Dieneret al., 2009), Positive and Negative Affect Schedule - Negative Scale (Watsonet al., 1988), generalised anxiety disorder seven-item (Spitzeret al., 2006) and repetitive thinking questionnaire-10 (McEvoyet al., 2010).FindingsParticipants who experienced high levels of psychological flourishing, emotional stability, self-compassion, perceived control and affective well-being were prone to experience minimal UITs. Anxiety was positively related to UITs. These findings suggest that these aspects of affectivity may aid the reduction or management of clinical and non-clinical unwanted intrusive thoughts.Originality/valueThis study has addressed gaps in knowledge and the literature on UITs by demonstrating that psychological flourishing, emotional stability, self-compassion, perceived control and affective well-being as aspects of affectivity can be implemented as a reductive mechanism for UITs, and such implementation may have a high probability of effective reduction or management of clinical and non-clinical unwanted intrusive thoughts.
Evaluation of complications in urgent start peritoneal dialysis: Single‐center experience
Authors: Balkoca Murat , Turkmen Ercan , Dilek Melda , Arik Nurol , Sayarlioglu Hayriye 
Published: August 2022

AbstractBackgroundPatients who were urgent start peritoneal dialysis (USPD) were evaluated in terms of complications.MethodsThe data from 102 patients (43 males and 59 females, mean age 58.18 ± 15.3 years) who were on peritoneal dialysis with a placed catheter between January 2014 and June 2019 in our Nephrology clinic was evaluated. The patients were divided into three groups according to the starting time of peritoneal dialysis. The development of complications between the groups (peritonitis, leakage, hernia), hemodialysis return time and overall survival times were compared.ResultsThere was no difference between the groups in terms of survival and complications. Diabetes, advanced age, albumin values were found to be risk factors for mortality, while no differences were found between the groups in terms of complications and mortality.ConclusionUSPD can be recommended for both because it provides a permanent dialysis option and because it leads to fewer complications than urgent start HD.
Clinical performance comparison of two medium cut‐off dialyzers
Authors: Krieter Detlef H. , Rüth Marieke , Lemke Horst‐Dieter , Wanner Christoph 
Published: August 2022

AbstractIntroductionMedium‐cut‐off (MCO) dialyzers may beneficially impact outcomes in patients on hemodialysis.MethodsIn a randomized, controlled trial in maintenance hemodialysis patients, the new Nipro ELISIO‐17HX MCO dialyzer was compared to the Baxter Theranova 400 filter regarding middle molecule removal. Furthermore, the suitability of two assays for free lambda‐light chain (λFLC) detection (Freelite vs. N‐Latex) was verified.ResultsELISIO‐HX achieved slightly lower reduction ratios for β2‐microglobulin (71.8 ± 6.0 vs. 75.3 ± 5.8%; p = 0.001), myoglobin (54.7 ± 8.6 vs. 64.9 ± 8.7%; p < 0.001), and kappa‐FLC (62.1 ± 8.8 vs. 56.3 ± 7.7%; p = 0.021). λFLC reduction ratios were more conclusive with the Freelite assay and not different between ELISIO‐HX and Theranova (28.4 ± 3.9 vs. 38.7 ± 13.4%; p = 0.069). The albumin loss of Theranova was considerably higher (2.14 ± 0.45 vs. 0.77 ± 0.25 g; p = 0.001) and the Global Removal ScoreLoss alb largely inferior (30.6 ± 7.4 vs. 82.4 ± 29.2%/g; p = 0.006) to ELISIO‐HX.ConclusionsThe new ELISIO‐HX expands the choice of dialyzers for MCO hemodialysis.
Mitigating the Influence of Analysts Who Issue Aggressive Stock Price Targets: The Role of Joint Versus Separate Evaluation*
Authors: Chee Vincent , Savani Krishna , Tan Seet‐Koh 
Published: August 2022

ABSTRACTInvestors frequently rely on individual analysts' stock price targets. Aggressive price targets often reflect analysts' attempts to strategically influence investors. Therefore, investors' welfare may be compromised if they take aggressive price targets at face value. In this study, we examine conditions under which investors are more likely to infer that analysts who issue aggressive price targets are acting strategically. Investors can evaluate multiple analysts' price targets with or without other related information (e.g., earnings estimates). Investors can also evaluate the information provided by multiple analysts jointly or separately one analyst at a time. Two experiments find that as predicted, when investors evaluate multiple analysts' price targets without earnings estimates, there is no difference in investors' perceptions about whether the aggressive analyst is acting strategically across joint versus separate evaluation. However, also as predicted, when investors evaluate multiple analysts' price targets along with their earnings estimates, investors perceive the aggressive analyst as acting more strategically under joint evaluation than under separate evaluation. Our findings suggest that jointly evaluating multiple analysts' price targets with other related information, such as earnings estimates, can reduce the likelihood that investors would be overly influenced by aggressive analysts.
Applicability of the IrisPlex system for eye color prediction in an admixed population from Argentina
Authors: Hohl Diana María , González Rebeca , Di Santo Meztler Gabriela Paula , Patiño‐Rico Jessica , Dejean Cristina , Avena Sergio , Gutiérrez María De Los Ángeles , Catanesi Cecilia Inés 
Published: August 2022

AbstractEye color prediction based on an individual's genetic information is of interest in the field of forensic genetics. In recent years, researchers have studied different genes and markers associated with this externally visible characteristic and have developed methods for its prediction. The IrisPlex represents a validated tool for homogeneous populations, though its applicability in populations of mixed ancestry is limited, mainly regarding the prediction of intermediate eye colors. With the aim of validating the applicability of this system in an admixed population from Argentina (n = 302), we analyzed the six single nucleotide variants used in that multiplex for eye color and four additional SNPs, and evaluated its prediction ability. We also performed a genotype–phenotype association analysis. This system proved to be useful when dealing with the extreme ends of the eye color spectrum (blue and brown) but presented difficulties in determining the intermediate phenotypes (green), which were found in a large proportion of our population. We concluded that these genetic tools should be used with caution in admixed populations and that more studies are required in order to improve the prediction of intermediate phenotypes.