bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRE-OPerative ECHOcardiograhy for prevention of cardiovascular events after non-cardiac surgery in intermediate- and high-risk patients: protocol for a low-interventional, mixed-cohort prospective study design (PREOP-ECHO)
Authors: Kim Eun Kyoung , Choi Hong-Mi , Choi Eui-Young , Lee Hye Sun , Park Goeun , Han Dong Woo , Lee Sang-Eun , Park Chan Seok , Hwang Ji-won , Choi Jae Hyuk , Kim Mi-Na , Kim Hyung-Kwan , Kim Dae-Hee , Shin Sung-Hee , Sohn Il Suk , Shin Mi-Seung , Na Jin Oh , Cho Iksung , Lee Sun Hwa , Park Yong Hyun , Park Tae-Ho , Kim Kye Hun , Cho Goo-Young , Jung Hae Ok , Park Dae-Gyun , Hong Ji Yeon , Kang Duk-Hyun 
Published: September 2022

Abstract
Background
Cardiac evaluation using transthoracic echocardiography before noncardiac surgery is common in real-world practice. However, evidence supporting preoperative echocardiography is lacking. This study aims to evaluate the additional benefit of preoperative echocardiography in predicting postoperative cardiovascular events (CVE) in noncardiac surgery.

Methods
This study is designed as a multicenter, prospective study to assess the utility of preoperative echocardiography in patients undergoing intermediate- or high-risk noncardiac surgery. This trial comprises two studies: (1) a randomized controlled trial (RCT) for patients undergoing intermediate-risk surgery with fewer than three clinical risk factors from the revised cardiac risk index (intermediate-risk group) and (2) a prospective cohort study for patients undergoing intermediate-risk surgery with three or more clinical risk factors, or who undergo high-risk surgery regardless of the number of clinical risk factors (high-risk group). We hypothesize that the use of preoperative echocardiography will reduce postoperative CVEs in patients undergoing intermediate- to high-risk surgery through discovery of and further intervention for unexpected cardiac abnormalities before elective surgery. A total of 2330 and 2184 patients will be enrolled in the two studies. The primary endpoint is a composite of all-cause death; aborted sudden cardiac arrest; type I acute myocardial infarction; clinically diagnosed unstable angina; stress-induced cardiomyopathy; lethal arrhythmia, such as sustained ventricular tachycardia or ventricular fibrillation; and/or newly diagnosed or acutely decompensated heart failure within 30 days after surgery.

Discussion
This study will be the first large-scale prospective study examining the benefit of preoperative echocardiography in predicting postoperative CVE. The PREOP-ECHO trial will help doctors identify patients at risk of postoperative CVE using echocardiography and thereby reduce postoperative CVEs.

Trial registration
The Clinical Research Information Service KCT0006279 for RCT and KCT0006280 for prospective cohort study. Registered on June 21, 2021.
Perioperative statin medication impairs pulmonary outcome after abdomino-thoracic esophagectomy
Authors: Reichert Martin , Lang Maike , Pons-Kühnemann Joern , Sander Michael , Padberg Winfried , Hecker Andreas 
Published: September 2022

Abstract

Background
Although surgery is the curative option of choice for patients with locally advanced esophageal cancer, morbidity, especially the rate of pulmonary complications, and consequently mortality of patients undergoing abdomino-thoracic esophagectomy remain unacceptably high. Causes for developing post-esophagectomy pulmonary complications are trauma to the lung and thoracic cavity as well as systemic inflammatory response. Statins are known to influence inflammatory pathways, but whether perioperative statin medication impacts on inflammatory response and pulmonary complication development after esophagectomy had not been investigated, yet.

Methods
Retrospective analysis and propensity score matching of patients, who either received perioperative statin medication [statin( +)] or not [statin( −)], with regard to respiratory impairment (PaO2/FiO2 < 300 mmHg), pneumonia development, and inflammatory serum markers after abdomino-thoracic esophagectomy.

Results
Seventy-eight patients who underwent abdomino-thoracic esophagectomy for cancer were included into propensity score pair-matched analysis [statin( +): n = 26 and statin( −): n = 52]. Although no differences were seen in postoperative inflammatory serum markers, C-reactive protein values correlated significantly with the development of pneumonia beyond postoperative day 3 in statin( −) patients. This effect was attenuated under statin medication. No difference was seen in cumulative incidences of respiratory impairment; however, significantly higher rate (65.4% versus 38.5%, p = 0.0317, OR 3.022, 95% CI 1.165–7.892) and higher cumulative incidence (p = 0.0468) of postoperative pneumonia were seen in statin( +) patients, resulting in slightly longer postoperative stay on intensive care unit (p = 0.0612) as well as significantly prolonged postoperative in-hospital stay (p = 0.0185).

Conclusions
Development of pulmonary complications after abdomino-thoracic esophagectomy is multifactorial but frequent. The establishment of preventive measures into the perioperative clinical routine is mandatory for an improved patient outcome. Perioperative medication with statins might influence pneumonia development in the highly vulnerable lung after abdomino-thoracic esophagectomy. Perioperative interruption of statin medication might be beneficial in appropriate patients; however, further clinical trials and translational studies are needed to prove this hypothesis.
Travel related histoplasmosis – a diagnostic challenge in a patient with tumor necrosis factor alpha (TNF-α) inhibitor therapy
Authors: Hofmann Eveline , Mühlethaler Konrad , Pollak Matthias , Ott Daniel , Bienz Nora , Zimmerli Stefan , Hirzel Cédric 
Published: September 2022

Abstract
Introduction
In a non-endemic setting, disseminated histoplasmosis is a rare travel-related health problem of immunosuppressed returnees from endemic regions.

Methods
We describe the case of a 68-year-old man with rheumatoid arthritis and tumor necrosis factor alpha (TNF-α) inhibitor treatment-related immunodeficiency, who suffered from disseminated histoplasmosis after traveling to Brazil. Based on this case, we discuss challenges and pitfalls associated with the diagnosis of disseminated histoplasmosis in a non-endemic setting.

Results
The disease mimicked a hemophagocytic lymphohistiocytosis (HLH) like syndrome. Histoplasma capsulatum was microscopically detected in bronchoalveolar fluid and bone marrow aspirate smears, but was initially misclassified as Leishmania spp., another class of pathogens, which may cause HLH like syndromes in immunocompromised individuals.

Discussion
Since the clinical symptoms of histoplasmosis are nonspecific and physicians in non-endemic regions might not be familiar with this disease pattern, there is a risk of delayed diagnosis of travel related cases. Taking a thorough travel history is key in unclear cases of illness in immunocompromised patients.
A feasibility study of a randomized controlled trial protocol to assess the impact of an eHealth intervention on the provision of dietary advice in primary care
Authors: Jefferson Katherine , Ward Michael , Pang Wei-Hsi , Arcand JoAnne 
Published: September 2022

Abstract
Background
Canadian sodium intakes remain high despite population-wide sodium reduction initiatives, highlighting the need for personal action in reducing dietary sodium. eHealth interventions support patients in dietary change and assist clinicians in decision-making and delivering care, including provision of advice. To date, impact of diet-focused eHealth tools, like the Sodium Calculator (SC) dietary screening tool, on clinical outcomes has received minimal examination. This study assessed feasibility of a randomized controlled trial (RCT) protocol to examine the impact of the SC, a physician-focused intervention, on the quality of dietary sodium reduction advice provided by physicians to their patients with hypertension.

Methods
Primary care physicians from community-based primary care clinics were randomized to one of two groups: (1) ‘usual care’ for dietary sodium counselling or (2) dietary sodium counselling using the SC (‘experimental group’). The primary endpoint was protocol feasibility defined by the following outcomes: process (e.g. recruitment, retention, protocol adherence, acceptability of intervention), resources (e.g. needs, impact on workflow), and management (e.g. staff requirements). Outcomes were assessed using direct observation, interviews, and questionnaires with patients, physicians, and clinic staff.

Results
Seven physicians (n = 4 in experimental group, n = 3 in usual care group) and 65 patients with hypertension (48.5% men, 69.8 ± 10.1 years) successfully participated. The main challenges identified is related to recruitment rate (48% for patients, 20% for physicians) and physician protocol adherence (76%). These improved with minor protocol modifications. There were several areas of protocol success such as no disruption to physician workflow, hiring clinic nurses as research staff, having a physician site lead to support physician recruitment, and a ‘Protocol Prompt Form’ to increase physician protocol adherence. Importantly, there was a high degree of acceptability of the SC intervention among experimental group physicians [n = 3 (75%)].

Conclusions
The modified RCT protocol was considered feasible. The identified successes can be leveraged, and the risks can be mitigated, during implementation of a full-scale RCT. Assessment of this RCT protocol is an important step in understanding the effectiveness of diet-focused eHealth tools to supporting physician self-efficacy in assessing, monitoring, and implementing dietary advice in routine clinical practice and supporting patients in effective behaviour change.
Practice Patterns and Perspectives on Stereotactic Body Radiation Therapy for the Metastatic Spine From Lower- and Middle-Income Countries
Authors: Pathak Rima Sanjay , Tibdewal Anil , Kinhikar Rajesh , Wakeham Katherine , Akbarov Kamal , Cordero Lisbeth , Khandavalli Ashwini , Agarwal Jai Prakash 
Published: September 2022

PURPOSE We wanted to understand the current practice patterns and stereotactic body radiation therapy (SBRT) utilization for spine metastases in lower- and middle-income countries (LMICs). METHODS A questionnaire was designed to identify the current practice patterns of treating spine metastases, uptake of spine SBRT in routine care, dose fractionations commonly used, and the perceived benefits and toxicities of using ablative doses. Individuals registering for a spine SBRT workshop were requested to answer the questionnaire. RESULTS We received 395 responses from radiation oncologists (ROs) working in 12 different LMICs. The majority of respondents were from an academic institute (57.5%). Two hundred seventy-four respondents further identified themselves from the government/public sector (44.89%), corporate/private sector (47.89%), not-for-profit organization (5.4%), or public-private partnership (5.4%). The respondents indicated that 8.43%, 27.46%, 41.73%, and 10.04% of the spine metastases patients are treated using clinical marking, X-ray–based, 3D conformal radiation therapy, and SBRT, respectively. A third of the respondents did not have any experience of spine SBRT; those with high-volume practice were predominantly from an academic institute. The majority of respondents would use spine SBRT to reduce pain severity (71.9%) and achieve durable pain control (61.01%) in the setting of oligometastases (92.73%) and reirradiation (56.69%). Respondents preferred 3- to 5-fraction regimens (64.9%) over 1-2 fractions (33.68%). The top three reasons for not using spine SBRT were resource constraints (50%), lack of machine (37.11%), and lack of training (27.34%). CONCLUSION There is heterogeneity in spine SBRT practice and utilization between academic and nonacademic institutes. Resource and infrastructure constraints along with lack of training are limiting the use of SBRT among ROs from LMICs. Collaborative studies from LMICs will help in resolving unique challenges posed by resource constraints.
Molecular Tumor Board–Assisted Care in an Advanced Cancer Population: Results of a Phase II Clinical Trial
Authors: Miller Rachel W. , Hutchcraft Megan L. , Weiss Heidi L. , Wu Jianrong , Wang Chi , Liu Jinpeng , Jayswal Rani , Buchanan Mikayla , Anderson Abigail , Allison Derek B. , El Khouli Riham H. , Patel Reema A. , Villano John L. , Arnold Susanne M. , Kolesar Jill M. 
Published: September 2022

PURPOSEMultidisciplinary molecular tumor boards (MTBs) interpret next-generation sequencing reports and help oncologists determine best therapeutic options; however, there is a paucity of data regarding their clinical utility. The purpose of this study was to determine if MTB-directed therapy improves progression-free survival (PFS) over immediately prior therapy in patients with advanced cancer.METHODSThis single-arm, prospective phase II clinical trial enrolled patients with advanced cancer with an actionable mutation who received MTB-recommended targeted therapy between January 1, 2017, and October 31, 2020. MTB-recommended both on-label (level 1 evidence) and off-label (evidence levels 2 and 3) therapies. Of the 93 enrolled patients, 43 were treated frontline and 50 received second-line or greater-line therapy. The primary outcome was the probability of patients treated with second-line or greater-line MTB-directed therapy who achieved a PFS ratio ≥ 1.3 (PFS on MTB-directed therapy divided by PFS on the patient's immediately prior therapy). Secondary outcomes included PFS for patients treated frontline and overall survival and adverse effects for the entire study population.RESULTSThe most common disease sites were lung (35 of 93, 38%), gynecologic (17 of 93, 18%), GI (16 of 93, 17%), and head and neck (7 of 93, 8%). The Kaplan-Meier estimate of the probability of PFS ratio ≥ 1.3 was 0.59 (95% CI, 0.47 to 0.75) for patients treated with second-line or greater-line MTB-directed therapy. The median PFS was 449 (range 42-1,125) days for patients treated frontline. The median overall survival was 768 (range 22-1,240) days. There were four nontreatment-related deaths.CONCLUSIONWhen treated with MTB-directed therapy, most patients experienced improved PFS compared with immediately prior treatment. MTB-directed targeted therapy may be a strategy to improve outcomes for patients with advanced cancer.
Advances on the roles of tenascin-C in cancer
Authors: Yilmaz Alev , Loustau Thomas , Salomé Nathalie , Poilil Surendran Suchithra , Li Chengbei , Tucker Richard P. , Izzi Valerio , Lamba Rijuta , Koch Manuel , Orend Gertraud 
Published: September 2022

ABSTRACT
The roles of the extracellular matrix molecule tenascin-C (TNC) in health and disease have been extensively reviewed since its discovery over 40 years ago. Here, we will describe recent insights into the roles of TNC in tumorigenesis, angiogenesis, immunity and metastasis. In addition to high levels of expression in tumors, and during chronic inflammation, and bacterial and viral infection, TNC is also expressed in lymphoid organs. This supports potential roles for TNC in immunity control. Advances using murine models with engineered TNC levels were instrumental in the discovery of important functions of TNC as a danger-associated molecular pattern (DAMP) molecule in tissue repair and revealed multiple TNC actions in tumor progression. TNC acts through distinct mechanisms on many different cell types with immune cells coming into focus as important targets of TNC in cancer. We will describe how this knowledge could be exploited for cancer disease management, in particular for immune (checkpoint) therapies.
Barriers and facilitators to maternal death surveillance and response at a busy urban National Referral Hospital in Uganda
Authors: Namagembe Imelda , Beyeza-Kashesya Jolly , Rujumba Joseph , K.Kaye Dan , Mukuru Moses , Kiwanuka Noah , Moffett Ashley , Nakimuli Annettee , Byamugisha Josaphat 
Published: September 2022

Background: Preventable maternal and newborn deaths remain a global concern, particularly in low- and middle-income countries. Timely maternal death surveillance and response (MDSR) is a recommended strategy to account for such deaths through identifying contextual factors that contributed to the deaths to inform recommendations to implement in order to reduce future deaths. With the leadership of WHO and UNFPA, there is momentum to roll out MDSR, however, the barriers and enablers for implementation have received limited attention. These have important implications for successful implementation. The aim of this study was: To assess barriers and facilitators to implementation of MDSR at a busy urban National Referral Hospital as perceived by health workers, administrators, and other partners in Reproductive Health. Methods: Qualitative study using in-depth interviews (24), 4 focus-group discussions with health workers, 15 key-informant interviews with health sector managers and implementing partners in Reproductive-Health. We conducted thematic analysis drawing on the Theory of Planned Behaviour (TPB). Results: The major barriers to implementation of MDSR were: inadequate knowledge and skills; fear of blame and litigation; failure to implement recommendations; burn out because of workload at the National Referral Hospital and inadequate leadership- to support health workers. Major facilitators were involving all health workers in the MDSR process, eliminate blame, strengthen leadership, implement recommendations from MDSR and functionalize lower health facilities (especially Health Centre -IVs). Conclusions: The barriers of MDSR include knowledge and skills gaps, fear of blame and litigation, and other health system factors such as erratic emergency supplies, and leadership/governance challenges. Efforts to strengthen MDSR for impact should use health system responsiveness approach to address the barriers identified, constructive participation of health workers to harness the facilitators and addressing the required legal framework.
On Fault-Tolerant Low-Diameter Clusters in Graphs
Authors: Lu Yajun , Salemi Hosseinali , Balasundaram Balabhaskar , Buchanan Austin 
Published: September 2022

Cliques and their generalizations are frequently used to model “tightly knit” clusters in graphs and identifying such clusters is a popular technique used in graph-based data mining. One such model is the s-club, which is a vertex subset that induces a subgraph of diameter at most s. This model has found use in a variety of fields because low-diameter clusters have practical significance in many applications. As this property is not hereditary on vertex-induced subgraphs, the diameter of a subgraph could increase upon the removal of some vertices and the subgraph could even become disconnected. For example, star graphs have diameter two but can be disconnected by removing the central vertex. The pursuit of a fault-tolerant extension of the s-club model has spawned two variants that we study in this article: robust s-clubs and hereditary s-clubs. We analyze the complexity of the verification and optimization problems associated with these variants. Then, we propose cut-like integer programming formulations for both variants whenever possible and investigate the separation complexity of the cut-like constraints. We demonstrate through our extensive computational experiments that the algorithmic ideas we introduce enable us to solve the problems to optimality on benchmark instances with several thousand vertices. This work lays the foundations for effective mathematical programming approaches for finding fault-tolerant s-clubs in large-scale networks. History: Accepted by David Alderson, Area Editor for Network Optimization: Algorithms & Applications. Funding: The computing for this project was performed at the High Performance Computing Center at Oklahoma State University supported in part through the National Science Foundation [Grant OAC-1531128]. This material is based upon work supported by the National Science Foundation under [Grants 1662757 and 1942065]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/ijoc.2022.1231 .
Memperkuat Peranan BUMDes untuk Mewujudkan Desa Mandiri Melalui Penggunaan Teknologi APOCI (Automatic Pond Circulation) Budidaya Udang Vannamei
Authors: Nurif Muhammad , Rahmawati Deti , Fahmi Muhammad Arfan , Muhibbin Zainul , Rahadiantino Lienggar 
Published: September 2022

Luasnya lahan sawah dan tambak di desa siderejo belum mampu memberikan dampak kesejahteraan pangan bagi masyarakat. Desa ini memiliki banyak tanah sawah tambak yang dimanfaatkan oleh penduduk desa untuk melakukan tambak udang, jenis udang yang ditambak adalah udang Vannemei. Namun tingkat produktivitasnya masih tergolong rendah, mengingat luas lahan sawah tambak di Desa Siderejo cukup luas. Program pengabdian kepada masyarakat ini bertujuan untuk memberdayakan masyarakat dengan mengembangkan teknologi budidaya udang Vannamei melalui peran BUMDes. Hasil dan luaran kegiatan setelah dilaksanakan sosialisasi dan pelatihan adalah masyarakat sasaran mengalami peningkatan pemahaman dan penggunaan teknologi budidaya udang Vannamei. masyarakat ini maka terjadi peningkatan dan perbaikan kemampuan dan keterampilan penggunaan teknologi APOCI (Automatic Pond Circulation) budidaya udang Vannamei yang dapat mendukung terjadinya peningkatan kegiatan ekonomis dan nilai tambah masyarakat.
Peningkatan Kemampuan dan Skill Mahasiswa Tingkat Akhir FEB IIB Darmajaya dalam Penulisan Karya Ilmiah
Authors: Saputra Muhammad 
Published: September 2022

Tenaga pendidik (dosen) memiliki peranan penting dalam membekali mahasiswanya dengan pemahaman tentang penulisan kaidah-kaidah baku yang harus dipatuhi dalam penulisan ilmiah tugas akhir atau skripsi. Fakultas Ekonomi dan Bisnis (FEB) merupakan fakultas yang ada di IIB Darmajaya yang memiliki jumlah mahaiswa terbanyak di IIB Darmajaya. penyusunan tugas akhir atau skripsi Fakultas ekonomi dan Bisnis (FEB) dilakukan dengan mengajukan proposal ke program studi yang selanjutnya akan dilakukan pengecekan oleh Koordinator Bidang Keilmuan (KBK) konsentrasi program studi. Berdasarkan hasil pengecekan, ditemukan kasus yang ditemukan pada karya ilmiah tugas akhir atau skripsi yang disusun oleh mahasiswa ialah ketidaksesuaian antara tulisan yang dihasilkan dengan tuntunan penyusunan karya ilmiah yang tepat. Selain itu penyusunan karya ilmiah yang dilakukan mahasiswa cenderung mengabaikan kutipan referensi yang digunakan. diperlukan sebuah pelatihan guna meningkatkan pemahaman mengenai penulisan tugas akhir atau skripsi bagi mahasiswa tingkat akhir sehingga menghasilkan hasil riset yang baik dan bermanfaat bagi bidang keilmuan. Kegiatan pengabdian ini dilakukan dengan memberikan mengenai kaidah penulisan tugas akhir atau skripsi. Praktik dalam pencarian dan pemilihan jurnal atau referensi yang relevan dengan topik penelitian serta pelatihan berupa praktik dalam penggunaan tools atau software (Publish or Perish dan Mendeley) guna mendukung penulisan tugas akhir atau skripsi. Kegiatan pengabdian yang dilakukan berjalan dengan lancar dan berdampak positif dalam pengembangan karya tulis ilmiah bagi mahasiswa IIB Darmajaya