bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection storage time of mild bruise’s yellow peaches using the combined hyperspectral imaging and machine learning method
Authors: Li Bin , Yin Hai , Liu Yan-de , Zhang Feng , Yang A.-kun , Su Cheng-tao , Ou-yang Ai-guo 
Published: July 2022

AbstractTo deduce the process of bruise and reduce the number of bruised fruits from the source, the storage time of yellow peaches after bruise should be identified. In order to distinguish the different storage times of mild bruise’s yellow peaches more effectively than current detection methods, the combined hyperspectral imaging and machine learning method was proposed. Firstly, the sample bruise region spectrum was extracted as spectral features, and then, the hyperspectral images were processed by Principal Component Analysis (PCA), and eight single-wavelength images were selected according to the weight coefficient curve of PC1 images, and the gray values of the selected images were calculated as image features. Finally, in order to find the optimal discriminative model, random forest (RF), support vector machine (SVM), and extreme gradient boosting (XGBoost) models were built based on spectral features, image features, and spectral features combined with image features, respectively. The results show that the XGBoost models based on spectral features, image features, and spectral features combined with image features are the optimal models with the overall accuracy of 77.50%, 87.50% and 90.00%, respectively. To simplify the model, Competitive Adaptive Reweighted Sampling (CARS) algorithm was used to screen the wavelength of the normalized spectral data, and then they were fused with the image feature data again and the XGBoost model with an overall model accuracy of 95.00% was built. To sum up, the combined hyperspectral imaging and machine learning method can be used to distinguish the different storage times (2 h, 8 h, 24 h and 48 h) of mild bruise’s yellow peaches effectively. It provides a certain theoretical basis for hyperspectral imaging technology in fruit bruise detection.
Nanoparticles for the treatment of glaucoma-associated neuroinflammation
Authors: Lambuk Lidawani , Suhaimi Nurfatihah Azlyna Ahmad , Sadikan Muhammad Zulfiqah , Jafri Azliana Jusnida Ahmad , Ahmad Suhana , Nasir Nurul Alimah Abdul , Uskoković Vuk , Kadir Ramlah , Mohamud Rohimah 
Published: July 2022

AbstractRecently, a considerable amount of literature has emerged around the theme of neuroinflammation linked to neurodegeneration. Glaucoma is a neurodegenerative disease characterized by visual impairment. Understanding the complex neuroinflammatory processes underlying retinal ganglion cell loss has the potential to improve conventional therapeutic approaches in glaucoma. Due to the presence of multiple barriers that a systemically administered drug has to cross to reach the intraocular space, ocular drug delivery has always been a challenge. Nowadays, studies are focused on improving the current therapies for glaucoma by utilizing nanoparticles as the modes of drug transport across the ocular anatomical and physiological barriers. This review offers some important insights on the therapeutic advancements made in this direction, focusing on the use of nanoparticles loaded with anti-inflammatory and neuroprotective agents in the treatment of glaucoma. The prospect of these novel therapies is discussed in relation to the current therapies to alleviate inflammation in glaucoma, which are being reviewed as well, along with the detailed molecular and cellular mechanisms governing the onset and the progression of the disease.
Guanxi in an age of digitalization: toward assortation and value homophily in new tie-formation
Authors: Au Anson 
Published: July 2022

AbstractHow do people form personal ties? A consensus holds in sociological and social network scholarship that in-person networks are dominated by status homophily and thatguanxinetworks rely extensively on balance. This article argues that social networking sites (SNSs) reconceptualize the character of homophily and tie-formation altogether inguanxinetworks. Drawing on 50 semi-structured interviews with Hong Kong youth from 2017 to 2020, this article examines how the technical capabilities of SNSs and principles ofguanxiculture come together to erode status boundaries, create access to larger networks, and cause spillovers of information and tie strength. As a result, the basis of tie-formation inguanxinetworks on SNSs shifts from balance to assortation and status homophily to value homophily. In this transformed calculus of tie-formation, two typologies of values rise to the fore: substantive values that reflect opinions and interests, as well as structural values that reflect networkability.
Women living with HIV and dual contraceptive use in Ethiopia: systematic review and meta-analysis
Authors: Ayenew Asteray 
Published: July 2022

Abstract
Background
Despite different preventive strategies that have been implemented in the country, the prevalence of HIV/AIDS is still significantly increasing in Ethiopia. The concurrence of HIV and unintended pregnancy makes the use of dual contraception a back bone for the simultaneous protection against HIV, and unintended pregnancy. As a result, this systematic review and meta-analysis aimed to assess the prevalence and associated factors of dual contraceptive use among women living with HIV in Ethiopia.

Method
We used databases; (PubMed, Google Scholar, EMBASE, Cochrane Library, African Online Journals, and Hinary), other gray and online repository accessed studies were searched using different search engines. For critical appraisal of studies Newcastle-Ottawa Quality Assessment Scale (NOS) was used. The analysis was done using STATA 11 software. The Cochran Q test and I2 test statistics were used to assess the heterogeneity. To detect publication bias funnel plot and Egger’s test were used. The pooled prevalence of dual contraception use and the odds ratio (OR) with a 95% confidence interval was presented by using forest plots.

Result
Eleven studies were included in this review, with a total of 4083 women living with HIV in Ethiopia. The pooled prevalence of dual contraception use in Ethiopia was 34.08% (95%CI: 20.77–47.38). Having open partner discussion (OR = 3.96, 95%CI:2.3,6.8), provision of post test counseling (AOR = 4.38, 95%CI:2.93,6.54), disclosed HIV status to sexual partners (OR = 5.9, 95%CI:4.19,8.33), partner involvement in post-test counseling (OR = 3.52, 95%CI:2.37,5.23), and being on highly active antiretroviral therapy (HAART) (OR = 2.9, 95%CI:1.56,5.46) were the determinant factors of dual contraceptive use in Ethiopia.

Conclusion
The overall prevalence of dual contraceptive use among women living with HIV in Ethiopia was low. Having open partner discussion, provision of post-test counseling, disclosed HIV status to sexual partner, partner involvement in post-test counseling, and currently on highly active antiretroviral therapy (HAART) were the associated factors of dual contraceptive use. Therefore, efforts should be made to provide post-test counseling, and initiate partner involvement in post-test counseling. Moreover, promoting open partner discussion, counseling to disclose HIV status to their sexual partner and to start HAART will be helpful in enhancing the use of dual contraceptive method use.
Inflammation-associated premetastatic niche formation
Authors: Deguchi Atsuko , Maru Yoshiro 
Published: July 2022

AbstractMetastasis remains the leading cause of cancer-related death. In 1889, Stephen Paget originally proposed the theory “seed-and-soil.” Both cancer cell-intrinsic properties (“seed”) and fertile microenvironment (“soil”) are essential for metastasis formation. To date, accumulating evidences supported the theory using mouse models. The formation of a premetastatic niche has been widely accepted as an accel for metastasis. Similar to tumor microenvironment, various types of cells, such as immune cells, endothelial cells, and fibroblasts are involved in premetastatic niche formation. We have discovered that primary tumors hijack Toll-like receptor 4 (TLR4) signaling to establish a premetastatic niche in the lung by utilizing the endogenous ligands. In this review, we discuss the mechanisms that underlie inflammation-associated premetastatic niche formation upon metastasis, focusing especially on myeloid cells and macrophages as the cells executing and mediating complicated processes.
Development of scales to measure Lebanese university students’ perceived knowledge about and attitudes about cannabis use: initial psychometric properties
Authors: Mina Anthony , Rahme Clara , Hallit Souheil , Soufia Michel 
Published: July 2022

Abstract
Background
For a long period, cannabis in Lebanon was categorized as an illegal psychoactive substance criminalized by law, despite being the 3rd largest producer of cannabis resin after Morocco and Afghanistan. The current available literature on the topic in Lebanon is scarce, as perceived knowledge towards cannabis use in the general population is not well established, and public health policies are absent. In the context of future legalization of cannabis for both medical and recreational purposes, what is the public’s perception of cannabis perceived knowledge about and attitude against cannabis use? The objectives of this study were to create two scales to assess perceived knowledge towards cannabis use and attitude against cannabis use and check their psychometric properties in a sample of Lebanese university students.

Methods
The study was designed as a cross-sectional study involving 415 Lebanese university students aged between 18 and 30 years. Students were only recruited from one university and were sent an email with a brief description of the study and a link to the questionnaire. The questionnaire items covered perceived knowledge and attitude about cannabis use, recovered and adapted from available literature.

Results
Perceived knowledge items converged over a solution of four factors that had an Eigenvalue over 1, explaining a total of 64% of the variance (factor 1 = perceived knowledge about cannabis quality of life improvement; factor 2 = perceived knowledge about cannabis psychiatric use; factor 3 = perceived knowledge about cannabis risks; factor 4 = perceived knowledge about cannabis neurological use). Attitude items converged over a solution of two factors that had an Eigenvalue over 1, explaining a total of 58.2% of the variance (factor 1 = negative attitude about cannabis use; factor 2 = positive attitude about cannabis use). Good Cronbach’s alpha values were found for the perceived knowledge and attitude scales (α = 0.78 and α = 0.73 respectively). Greater perceived knowledge was found in male participants and in those who have tried cannabis for recreational purposes. Greater perceived knowledge was also associated with stronger attitude about cannabis use and older age. Furthermore, greater mean attitude about cannabis use scores were significantly found in male participants and in those who have tried cannabis for recreational or medicinal purposes.

Conclusion
Primary results showed acceptable psychometric properties for the perceived knowledge towards and attitudes about cannabis use scale. Further studies are needed in order to validate them among the general population and assess more psychometric properties of these scales.
Research recommendations to better understand the potential health impacts of microplastics to humans and aquatic ecosystems
Authors: Thornton Hampton Leah M. , Bouwmeester Hans , Brander Susanne M. , Coffin Scott , Cole Matthew , Hermabessiere Ludovic , Mehinto Alvine C. , Miller Ezra , Rochman Chelsea M. , Weisberg Stephen B. 
Published: July 2022

AbstractTo assess the potential risk of microplastic exposure to humans and aquatic ecosystems, reliable toxicity data is needed. This includes a more complete foundational understanding of microplastic toxicity and better characterization of the hazards they may present. To expand this understanding, an international group of experts was convened in 2020–2021 to identify critical thresholds at which microplastics found in drinking and ambient waters present a health risk to humans and aquatic organisms. However, their findings were limited by notable data gaps in the literature. Here, we identify those shortcomings and describe four categories of research recommendations needed to address them: 1) adequate particle characterization and selection for toxicity testing; 2) appropriate experimental study designs that allow for the derivation of dose-response curves; 3) establishment of adverse outcome pathways for microplastics; and 4) a clearer understanding of microplastic exposure, particularly for human health. By addressing these four data gaps, researchers will gain a better understanding of the key drivers of microplastic toxicity and the concentrations at which adverse effects may occur, allowing a better understanding of the potential risk that microplastics exposure might pose to human and aquatic ecosystems.
Effect of Diabetes on Morbidity and Mortality in Patients With Acromegaly
Authors: Esposito Daniela , Olsson Daniel S , Franzén Stefan , Miftaraj Mervete , Nåtman Jonatan , Gudbjörnsdottir Soffia , Johannsson Gudmundur 
Published: July 2022

Abstract

Context
Diabetes is a major risk factor for cardiovascular disease and death but its effect on outcomes in acromegaly is unknown.

Objective
This work aimed to study whether diabetes affects morbidity and mortality in patients with acromegaly.

Methods
A nationwide (Sweden), observational, matched-cohort study was conducted. Patients diagnosed with acromegaly between 1987 and 2020 were identified in the Swedish National Patient Registry and those with concomitant type 2 diabetes in the National Diabetes Registry and Drug Registry. The risk of overall mortality, and cardiovascular mortality and morbidity were estimated using Cox regression.

Results
The study included 254 patients with acromegaly and concomitant type 2 diabetes (ACRO-DM group) and 532 without diabetes (ACRO group). Mean (SD) age at baseline was 62.6 (11.4) and 60.0 (12.1) years (P = .004) and the mean (SD) duration of acromegaly was 6.8 (8.1) and 6.0 (6.2) years (P = .098) in the ACRO-DM and ACRO groups, respectively. Overall mean follow-up was 9.2 years. The unadjusted overall mortality rate per 1000 person-years was 35.1 (95% CI, 27.2-44.7) and 20.1 (95% CI, 16.5-24.3) in the respective groups. The hazard ratio (HR) for overall mortality adjusted for multiple confounders was 1.58 (95% CI, 1.12-2.23) in the ACRO-DM group compared with the ACRO group. Cardiovascular mortality (HR 2.11; 95% CI, 1.09-4.10) and morbidity (HR 1.49; 95% CI, 1.21-1.82) were also increased in the ACRO-DM group.

Conclusion
The presence of diabetes in patients with acromegaly was associated with increased overall mortality as well as increased cardiovascular mortality and morbidity.
The GH/IGF-1 Axis Is Associated With Intrahepatic Lipid Content and Hepatocellular Damage in Overweight/Obesity
Authors: Dichtel Laura E , Corey Kathleen E , Haines Melanie S , Chicote Mark L , Kimball Allison , Colling Caitlin , Simon Tracey G , Long Michelle T , Husseini Jad , Bredella Miriam A , Miller Karen K 
Published: July 2022

Abstract

Context
Obesity is a state of relative growth hormone (GH) deficiency, and GH has been identified as a candidate disease-modifying target in nonalcoholic fatty liver disease (NAFLD) because of its lipolytic and anti-inflammatory properties. However, the GH/IGF-1 axis has not been well characterized in NAFLD.

Objective
We aimed to investigate serum GH and IGF-1 levels in relation to intrahepatic lipid content (IHL) and markers of hepatocellular damage and fibrosis in NAFLD.

Methods
This cross-sectional study included 102 adults (43% women; age 19-67; BMI ≥ 25 kg/m2) without type 2 diabetes. IHL was measured by magnetic resonance spectroscopy; NAFLD was defined by ≥ 5% IHL. Peak-stimulated GH in response to GH releasing hormone and arginine was assessed as was serum IGF-1 (LC/MS).

Results
There was no difference in mean age, BMI, or sex distribution in NAFLD vs controls. Mean (± SD) IHL was higher in NAFLD vs controls (21.8 ± 13.3% vs 2.9 ± 1.1%, P &lt; 0.0001). Mean peak-stimulated GH was lower in NAFLD vs controls (9.0 ± 6.3 vs 15.4 ± 11.2 ng/mL, P = 0.003), including after controlling for age, sex, visceral adipose tissue, and fasting glucose. In a stepwise model, peak-stimulated GH predicted 14.6% of the variability in IHL (P = 0.004). Higher peak-stimulated GH was also associated with lower ALT. Higher serum IGF-1 levels were associated with lower risk of liver fibrosis by Fibrosis-4 scores.

Conclusion
Individuals with NAFLD have lower peak-stimulated GH levels but similar IGF-1 levels as compared to controls. Higher peak-stimulated GH levels are associated with lower IHL and less hepatocellular damage. Higher IGF-1 levels are associated with more favorable fibrosis risk scores. These data implicate GH and IGF-1 as potential disease modifiers in the development and progression of NAFLD.
Histopathology and Genetic Causes of Primary Aldosteronism in Young Adults
Authors: Nanba Kazutaka , Baker Jessica E , Blinder Amy R , Bick Nolan R , Liu Chia-Jen , Lim Jung Soo , Wachtel Heather , Cohen Debbie L , Williams Tracy Ann , Reincke Martin , Lyden Melanie L , Bancos Irina , Young William F , Else Tobias , Giordano Thomas J , Udager Aaron M , Rainey William E 
Published: July 2022

Abstract

Context
Due to its rare incidence, molecular features of primary aldosteronism (PA) in young adults are largely unknown. Recently developed targeted mutational analysis identified aldosterone-driver somatic mutations in aldosterone-producing lesions, including aldosterone-producing adenomas (APAs), aldosterone-producing nodules (APNs), and aldosterone-producing micronodules, formerly known as aldosterone-producing cell clusters.

Objective
To investigate histologic and genetic characteristics of lateralized PA in young adults.

Methods
Formalin-fixed, paraffin-embedded adrenal tissue sections from 74 young patients with lateralized PA (&lt;35 years old) were used for this study. Immunohistochemistry (IHC) for aldosterone synthase (CYP11B2) was performed to define the histopathologic diagnosis. Somatic mutations in aldosterone-producing lesions were further determined by CYP11B2 IHC-guided DNA sequencing.

Results
Based on the CYP11B2 IHC results, histopathologic classification was made as follows: 48 APAs, 20 APNs, 2 multiple aldosterone-producing nodules (MAPN), 1 double APN, 1 APA with MAPN, and 2 nonfunctioning adenomas (NFAs). Of 45 APAs with successful sequencing, 43 (96%) had somatic mutations, with KCNJ5 mutations being the most common genetic cause of young-onset APA (35/45, 78%). Of 18 APNs with successful sequencing, all of them harbored somatic mutations, with CACNA1D mutations being the most frequent genetic alteration in young-onset APN (8/18, 44%). Multiple CYP11B2-expressing lesions in patients with MAPN showed several aldosterone-driver mutations. No somatic mutations were identified in NFAs.

Conclusion
APA is the most common histologic feature of lateralized PA in young adults. Somatic KCNJ5 mutations are common in APAs, whereas CACNA1D mutations are often seen in APNs in this young PA population.
The Impact of Suppressing Estradiol During Ovarian Stimulation on the Unsupported Luteal Phase: A Randomized Controlled Trial
Authors: Dreyer Holt Marianne , Skouby Sven Olaf , Bülow Nathalie Søderhamn , Englund Anne Lis Mikkelsen , Birch Petersen Kathrine , Macklon Nicholas Stephen 
Published: July 2022

Abstract

Context
Supraphysiological sex steroid levels at the follicular-luteal phase transition are implicated as the primary cause of luteal insufficiency after ovarian stimulation (OS) for in vitro fertilization.

Objective
We aimed to determine the impact of suppressing estradiol levels during OS of multiple dominant follicles on the unsupported luteal phase and markers of endometrial maturation.

Methods
At 2 university hospitals, 25 eligible egg donors were randomized to undergo OS using exogenous gonadotropins with or without adjuvant letrozole 5 mg/day. Final oocyte maturation was triggered with a GnRH agonist. No luteal support was provided. The primary outcome was the duration of the luteal phase. Secondary outcomes were luteal phase hormone profiles and the endometrial transcriptomic signature 5 days after oocyte pick up (OPU + 5).

Results
The median (interquartile range [IQR]) luteal phase duration was 8.0 (6.8-11.5) days compared with 5.0 (5.0-6.8) days in the intervention and control group, respectively (P &lt; 0.001). Estradiol levels were effectively suppressed in the letrozole group with a median of 0.86 (0.23-1.24) nmol/L at OPU compared to 2.82 (1.34-3.44) nmol/L in the control group. Median (IQR) progesterone levels at OPU + 5 were 67.05 (15.67-101.75) nmol/L in the letrozole group vs 2.27 (1.05-10.70) nmol/L in the control group (P &lt; 0.001). In the letrozole group, 75% of participants revealed endometrial transcriptomic signatures interpreted as post-receptive. In the control group, 40% were post-receptive and 50% noninformative.

Conclusion
Suppressing estradiol levels in the follicular phase with adjuvant letrozole significantly reduces the disruption of the unsupported luteal phase after OS.
Weierstrass semigroups for maximal curves realizable as Harbater–Katz–Gabber covers
Authors: Charalambous Hara , Karagiannis Kostas , Karanikolopoulos Sotiris , Kontogeorgis Aristides 
Published: July 2022

Abstract
We present a necessary and sufficient condition for a maximal curve, defined over the algebraic closure of a finite field, to be realised as an HKG-cover. We use an approach via pole numbers in a rational point of the curve. For this class of curves, we compute their Weierstrass semigroup as well as the jumps of their higher ramification filtrations at this point, the unique ramification point of the cover.
Observational data and orbits of the comets discovered at the Vilnius Observatory in 1980–2006 and the case of the comet 322P
Authors: Włodarczyk Ireneusz , Černis Kazimieras 
Published: July 2022

Abstract
This article is devoted to the discovery of comets at the Vilnius Observatory together with the orbital analysis of dynamically interesting comets, namely 322P. We studied the orbital evolution of comet 322P with and without non-gravitational effects. It turned out that many of the comet’s orbital clones go into and out of retrograde orbits, sometimes repeatedly. The reason for such dramatic changes in the inclination of the orbit is the origin of comet 322P close to mean motion resonance 3:1 with Jupiter, ejecting them from there and, consequently, bringing the clones closer to the terrestrial group of planets. In this way, the clones of comet 322P enter retrograde orbits and reside there several ky to several My.