bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vitro Investigation on the Effect of Dendrobine on the Activity of Cytochrome P450 Enzymes
Authors: Wang Zhiheng , Zhou Kuilong , Liang Zhijie , Zhang Huiting , Song Yangjie , Yang Xiaomin , Xiang Dongguo , Xie Qingfan 
Published: May 2022

AbstractDendrobine is the major active ingredient of Dendrobium nobile, Dendrobium chrysotoxum, and Dendrobium fimbriatum, all of which are used in traditional Chinese medicine owing
to their antitumor and anti-inflammation activities. Hence, investigation on the interaction of dendrobine with cytochrome P450 enzymes could provide a reference for the clinical application
of Dendrobium. The effects of dendrobine on cytochrome P450 enzymes activities were investigated in the presence of 0, 2.5, 5, 10, 25, 50, and 100 µM dendrobine in pooled human liver
microsomes. The specific inhibitors were employed as the positive control and the blank groups were set as the negative control. The Lineweaver-Burk plots were plotted to characterize the
specific inhibition model and obtain the kinetic parameters. The study reveals that dendrobine significantly inhibited the activity of CYP3A4, 2C19, and 2D6 with IC50 values of
12.72, 10.84, and 15.47 µM, respectively. Moreover, the inhibition of CYP3A4 was found to be noncompetitive (Ki = 6.41 µM) and time dependent (KI = 2.541 µM−1,
Kinact
= 0.0452 min−1), while the inhibition of CYP2C19 and 2D6 was found to be competitive with the Ki values of 5.22 and 7.78 µM, respectively, and
showed no time-dependent trends. The in vitro inhibitory effect of dendrobine implies the potential drug-drug interaction between dendrobine and CYP3A4-, 2C9-, and 2D6-metabolized
drugs. Nonetheless, these findings need further in vivo validation.
Rolle systemischer Infektionen bei Nierenerkrankungen des Hundes
Authors: Preyß-Jägeler Christine , Hartmann Katrin , Dorsch Roswitha 
Published: May 2022

ZusammenfassungNierenerkrankungen sind häufige Erkrankungen und Todesursachen beim Hund. Insbesondere für Glomerulopathien und akute Nierenschädigungen können Infektionserreger ursächlich verantwortlich sein. Zu den Infektionen, die in Mittel- und Südeuropa häufig mit der Entstehung von Immunkomplex-Glomerulonephritiden assoziiert und in Deutschland als Reisekrankheiten von Bedeutung sind, gehören Leishmaniose, Dirofilariose und Ehrlichiose. Selten verursachen in Deutschland Anaplasmose, Hepatozoonose, Borreliose und eine durch kleine Babesien versursachte Babesiose Immunkomplex-Glomerulonephritiden. Leptospirose, canine infektiöse Hepatitis und eine durch große Babesien verursachte Babesiose können für akute Nierenschädigungen durch tubulointerstitielle Nephritiden verantwortlich sein. Eine weiterführende Diagnostik zur Identifikation potenziell auslösender Infektionen bei Nierenerkrankungen des Hundes ist daher wichtig für die Prognose und Therapie der Patienten.
Delayed Cord Clamping for 45 Seconds in Very Low Birth Weight Infants: Impact on Hemoglobin at Birth and Close to Discharge
Authors: Amendolia Barbara , Kilic Nicole , Afridi Faraz , Qari Omar , Bhat Vishwanath , Nakhla Daniel , Sadre Sara , Eckardt Rebecca , Nakhla Tarek , Bhandari Vineet , Aghai Zubair H. 
Published: May 2022

Objectives To assess the impact of delayed cord clamping (DCC) for 45 seconds on hemoglobin at birth and close to discharge in very low birth weight (VLBW) infants and to compare modes of delivery in infants who received DCC.
Study Design In a retrospective study, 888 VLBW infants (≤1,500 g) who survived to discharge and received immediate cord clamping (ICC) were compared with infants who received DCC. Infants who received DCC and born via Cesarean section (C-section) were compared with those born via vaginal birth.
Results A total of 555 infants received ICC and 333 DCC. Only 188 out of 333 VLBW infants (56.5%) born during the DCC period received DCC. DCC was associated with higher hemoglobin at birth (15.9 vs. 14.9 g/dL, p = 0.001) and close to discharge (10.7 vs. 10.1 g/dL, p < 0.001) and reduced need for blood transfusion (39.4 vs. 54.9%, p < 0.001). In the DCC group, hemoglobin at birth and close to discharge was similar in infants born via C-section and vaginal birth.
Conclusion DCC for 45 seconds increased hemoglobin at birth and close to discharge and reduced need for blood transfusion in VLBW infants. DCC for 45 seconds was equally effective for infants born by C-section and vaginal delivery. Approximately 44% of VLBW infants did not receive DCC even after implementing DCC guidelines.
Key Points
Effectiveness of Simulation Training in Acquiring Echocardiography Skills among Neonatology Care Providers
Authors: Noori Shahab , Ebrahimi Mahmood , Uzunyan Merujan , Bazyani Dariush , Noori Aryan J. , Siassi Bijan , Ramanathan Rangasamy 
Published: May 2022

Objectives The objective of this study was to test the hypothesis that simulation training improves echocardiography skills.
Study Design In this prospective study, 43 participants (16 neonatologists, 26 neonatology fellows, and 1 nurse practitioner) were tested on the simulator after 4 hours of didactic sessions on topographical cardiac anatomy and standard echocardiographic views. Participants were given 20 minutes to obtain and save the standard views. After the simulation hands-on training for 8 hours over 3 days, they were tested again. Each image was scored from 0 to 3 based on the image quality. Pre- and postsimulator training data were compared using both automated and visual scoring methods.
Results After the hands-on simulator training, the automated median (interquartile) score for the quality of acquired images increased from 36 (22, 43) to 55 (48, 58), p < 0.0001. The increase was similar using visual scoring. The number of views with acceptable or good image quality (scores of 2 or 3) increased from 11 (6, 16) to 20 (17, 21), p < 0.0001. The neonatology fellows and faculty, as well as those with or without prior echocardiography experience, demonstrated significant improvement.
Conclusions Echocardiography simulation is an effective tool in improving echocardiography skills among neonatology care providers.
Key Points
Inhaled Corticosteroid Exposure in Hospitalized Infants with Bronchopulmonary Dysplasia
Authors: Leiting Chelsey , Kerns Ellen , Euteneuer Joshua C. , McCulloh Russell J. , Peeples Eric S. 
Published: May 2022

Objective The objective of this paper was to determine inhaled corticosteroid (IC) use in infants with bronchopulmonary dysplasia (BPD), define the interhospital variation of IC administration to infants with BPD, and compare clinical, demographic, and hospital factors associated with IC use.
Study Design Using the Pediatric Health Information System database, a retrospective multicenter cohort of 4,551 infants born at <32 weeks of gestation with developing BPD was studied. The clinical, demographic, and hospital characteristics of infants exposed and not exposed to ICs were compared.
Results IC use varied markedly between hospitals, ranging from 0 to 66% of infants with BPD exposed to ICs. Increased annual BPD census was not associated with IC use. In total, 25% (1,144 out of 4,551) of patients with BPD and 43% (536 out of 1,244) of those with severe BPD received ICs. Increased IC exposure was associated with lower birth weight and gestational age, days on respiratory support, need for positive pressure ventilation at 36-week postmenstrual age, need for tracheostomy, and increased use of systemic steroids, bronchodilators, and diuretics.
Conclusion IC exposure is common in infants with BPD, with substantial interhospital variability. IC use was associated with more severe disease. Hospital experience did not account for the wide variability in IC use by the hospital. Further research into the effects of ICs use is urgently needed to help guide their use in this vulnerable population.
Key Points
Formation of Seven-Membered Rings by Ring-Closing Metathesis of Vinyl Bromides
Authors: Ajavakom Vachiraporn , Brown Richard C. D. , Pandokrak Potchanee , Salim Sofia S. , Moustafa Gamal A. I. , Bellingham Richard K. , Hill-Cousins Joseph T. , Ajavakom Anawat 
Published: May 2022

AbstractA Grubbs II catalyst mediated ring-closing metathesis (RCM) of monobrominated dienes is reported to proceed in moderate to good yields (40–80%) where the linking chain contains five atoms, leading to carbocyclic and heterocyclic seven-membered bromoolefins. Notably, RCM to form five-, six-, or eight-membered bromoolefins was unsuccessful, with the exception of one example where RCM afforded diethyl 3-bromocyclohex-3-ene-1,1-dicarboxylate. In this case, a bromomethyl-substituted cyclohexene was obtained as a byproduct. The utility of selected bromoolefin RCM products was demonstrated through their participation in Suzuki–Miyaura reactions. Vinylic halide exchange (Br → Cl) was noted as a side reaction under RCM conditions.
Development of new gastric endoscopic submucosal dissection training model: A reproducibility evaluation study
Authors: Mitsui Tomohiro , Yoda Yusuke , Sunakawa Hironori , Takayama Seiichiro , Nishihara Keiichiro , Inaba Atsushi , Sato Daiki , Minamide Tatsunori , Takashima Kenji , Nakajo Keiichiro , Murano Tatsuro , Kadota Tomohiro , Shinmura Kensuke , Ikematsu Hiroaki , Yano Tomonori 
Published: May 2022

Abstract
Background and study aims Gastric endoscopic submucosal dissection (ESD) is a highly technical procedure mainly due to the distinctive shape of the stomach and diverse locations of lesions. We developed a new gastric ESD training model (G-Master) that could accurately recreate the location of the stomach and assessed the reproducibility of located lesions in the model.
Methods The model comprises a simulated mucous membrane sheet made of konjac flour and a setting frame, which can simulate 11 locations of the stomach. We assessed the reproducibility of each location in the model by assessing the procedure speed and using a questionnaire that was distributed among experts. In the questionnaire, each location was scored on a six-point scale for similarity of locations.
Results The mean score for all locations was high with > 4 points. Regarding locations, lower anterior and posterior walls had medium scores with 3 to 4 points. The procedure speed was slower in the greater curvature of the upper and middle gastric portions, where ESD is considered more difficult than the overall procedure speed.
Conclusions The new gastric ESD training model appears to be highly reproducible for each gastric location and its application for training in assuming actual gastric ESD locations.
A Facile Oxidation of Tertiary Amines to Lactams by Using Sodium Chlorite: Process Improvement by Precise pH Adjustment with CO2
Authors: Chu Changhu , Liu Chaoyang , Sun Haozhou , Qin Cheng , Yang Tiannuo , Zhang Wenxian , Zhou Yuan , Li Yani , Jia Zheng Robert 
Published: May 2022

AbstractBy using cheap and innocuous sodium chlorite, a series of tertiary amines have been oxidized to the corresponding lactams with good selectivity and high yield. In this method, neither transition-metal catalyst nor oxidant was used. In the oxidation step, the pH of the sodium chlorite was precisely adjusted to pH around 6 using CO2, such pH is a compromise between oxidative properties, chemical stability, and unwanted precipitation. In addition, buffer salts are not necessary, which allows this oxidation reaction to be performed under safe and environmentally benign conditions.
Methods for Determination of Absolute Configurations of Chiral Diols by THENA Ester and NMR Shift Difference
Authors: Thongpanchang Tienthong , Dolsophon Kulvadee , Soponpong Jakapun , Kornsakulkarn Jittra , Thongpanchang Chawanee 
Published: May 2022

AbstractDetermination of the absolute configuration of chiral secondary diols by chiral derivatizing agent (CDA) and NMR shift difference is of great challenge due to the complication from the interference of the aromatic anisotropic shielding effect of the two CDAs in close proximity. In this work, tetrahydro-1,4-epoxynaphthalene-1-carboxylic acid (THENA) was introduced as an alternative CDA for diols to overcome such complexity. Since the deshielding effect of THENA is weaker than the shielding effect of other CDAs, THENA would allow the direct analysis of the chemical shift difference in determining the absolute configuration of the chiral diols. In addition, an analytical method based on Riguera’s model could also be used to confirm the assignment. With a good agreement between the assigned configuration based on both analytical models, the absolute configuration of the chiral diols could be assigned with reliability.
Anesthetic Implications of Nephrotic Syndrome in Neurosurgical Practice
Authors: Puthiyedath Roshna C. , Kumar Ashutosh , Praveen Ranganatha , Sethuraman Manikandan 
Published: May 2022

AbstractNephrotic syndrome (NS) is a common medical disorder especially in pediatric population with hypoproteinemia as an important feature. NS has multisystem involvement and multiple organ effects due to the disease or the treatment itself, which has important implications in the perioperative period. Hypoproteinemia in NS can result in reduction in availability of protein binding sites for certain intravenous anesthetics, leading to their increased free fraction that can concentrate at the receptor sites, thereby prolonging their action. NS can have phases of relapse and remission with increased propensity for complications, such as thromboembolism during relapse phase. Such patients presenting for neurosurgery pose unique challenge to the anesthesiologist. We hereby report a case of NS and its implication in neurosurgical practice and management.
First Trimester Cardiac Biomarkers among Women with Peripartum Cardiomyopathy: Are There Early Clues to This Late-Pregnancy Phenomenon?
Authors: Sarma Amy A. , Hsu Sarah , Januzzi James L. , Goldfarb Ilona T. , Thadhani Ravi , Wood Malissa J. , Powe Camille E. , Scott Nandita S. 
Published: May 2022

Objective Whether biomarkers may enable early identification of women who develop peripartum cardiomyopathy (PPCM) prior to disease onset remains a question of interest.
Study Design A retrospective nested case–control study was conducted to determine whether first trimester N-terminal pro-B type natriuretic peptide (NT-proBNP) or high sensitivity cardiac troponin I (hs-cTnI) differed among women who developed PPCM versus unaffected pregnancies. Cases were matched to unaffected women by age, race, parity, and gestational age of sample (control A) and then further by blood pressure and pregnancy weight gain (control B).
Results First trimester NT-proBNP concentrations were numerically higher among women who subsequently developed PPCM (116 pg/mL [83–177]) as compared with women in control A (56.1 pg/mL [38.7–118.7], p = 0.3) or control B (37.6 [23.3 − 53.8], p <0.05). A higher proportion of women who subsequently developed PPCM (50%) had detectable levels of hs-cTnI as compared with control A (0%, p = 0.03) or control B (18.8%, p = 0.52). Among both cases and controls, hs-cTnI values were low and often below the limit of detection.
Conclusion There were differences in first trimester NT-proBNP and hs-cTnI concentrations between women who subsequently developed PPCM and those who did not, raising the possibility the early pregnancy subclinical myocardial dysfunction may be associated with this late-pregnancy disease.
Key Points
Mechanism of tethered agonist-mediated signaling by polycystin-1
Authors: Pawnikar Shristi , Magenheimer Brenda S. , Munoz Ericka Nevarez , Maser Robin L. , Miao Yinglong 
Published: May 2022

SignificanceMutations of polycystin-1 (PC1) are the major cause (85% of cases) of autosomal dominant polycystic kidney disease (ADPKD), which is the fourth leading cause of kidney failure. PC1 is thought to function as an atypical G protein-coupled receptor, yet the mechanism by which PC1 regulates G-protein signaling remains poorly understood. A significant portion of ADPKD mutations of PC1 encode a protein with defects in maturation or reduced function that may be amenable to functional rescue. In this work, we have combined complementary biochemical and cellular assay experiments and accelerated molecular simulations, which revealed an allosteric transduction pathway in activation of the PC1 C-terminal fragment. Our findings will facilitate future rational drug design efforts targeting the PC1 signaling function.
Methodology at work
Authors: Kyuseva Maria , Parina Elena , Ryzhova Daria 
Published: May 2022

Abstract
The chapter illustrates the frame-based methodology of lexical typological analysis through the comparison of the qualities sharp and blunt in 21 languages. We show that these qualities tend to be asymmetrical, with bluntness being negatively defined through sharpness. The two main oppositions found in the field are (1) the shape of a sharp object, and (2) the sense through which the quality is primarily experienced. The first opposition divides all objects into bladed (knives, etc.) and pointed (needles, etc.) ones; the second opposition contrasts touch with vision, and it further translates to the juxtaposition of function (sharp/blunt instruments, etc.) vs. shape (pointed/rounded features, etc.). We also find that these oppositions determine the semantic shifts developed by words denoting sharpness or bluntness and that the metaphoric patterns are consistent across languages.
Quality as a two-place predicate
Authors: Panina Anna , Tagabileva Maria 
Published: May 2022

Abstract
This chapter presents a typological description of the semantic domains empty and full. While the majority of other predicates of physical qualities have a single argument (the qualified object), the situations of fullness and emptiness imply two arguments – the container and the contents. Such argument structure influences the syntax of the predicates of fullness and emptiness and, to some extent, the oppositions within these domains. In this paper, empty and full are examined in relation to clean, bare, solid and several other adjacent semantic domains, with particular attention being given to metaphors and semantic extensions.
Typology of dimensions
Authors: Kozlov Alexey , Privizentseva Maria 
Published: May 2022

Abstract
The paper focuses on the lexical typology of dimensional terms such as English long, deep, wide, etc. Compared to other semantic fields, this one is relatively well-studied; however, the present study is the first to approach it from the modern typological point of view. We propose a semantic map of dimensional terms, which outlines the possible and impossible colexification patterns in the domain. However, other regularities appear likely to exist, which cannot be captured by the model of semantic mapping. We discuss the potential restrictions on colexifications, and suggest explanations for them.
The domain of surface texture
Authors: Kashkin Egor , Vinogradova Olga 
Published: May 2022

Abstract
The paper deals with the typology of surface texture expressions, such as
slippery road, smooth wooden board, rough hands, coarse
or
rough fabric. We discuss both their literal uses and metaphors formed with them, such as
slippery person, smooth speech, rugged captain. Our language sample includes 10 Uralic languages (Finnish, Estonian, Meadow Mari, Erzya, Moksha, Udmurt, Komi-Zyrjan, Hungarian, Khanty, Nenets), as well as 5 languages from other families (Russian, English, Spanish, Chinese, and Korean). The categorisation includes primarily a division into visually perceived surfaces and surfaces perceived through physical contact. We discuss in what ways the antonymic areas under observation are asymmetrical in their semantics and combinability. One more focus is on evaluating variation in the texture lexicon in genetically related languages in comparison with its variation across a broader sample of languages.
Talking temperature with close relatives
Authors: Koptjevskaja-Tamm Maria 
Published: May 2022

Abstract
The chapter compares the temperature adjectives (‘hot’, ‘cold’ etc.) across Slavic against a broader typological background. The comparison targets both the systems as a whole and the forms involved in them. The main questions are how (dis)similar the temperature systems of closely related languages can be, and what is stable vs. changeable in the temperature terms of closely related languages. Slavic languages show substantial cross-linguistic variation in their systems (ranging from two to four main temperature values), while on the whole confirming several earlier tentative generalizations in Koptjevskaja-Tamm (2015). The temperature terms themselves differ in stability, both in meaning and in form (with ‘warm’ being the most stable term on both counts), even though most of them are traceable to proto-Slavic and even to proto-Indo-European.
Ants.
Authors: Dhang Partho , Koehler Philip , Pereira Roberto , Dye, II Daniel D. 
Published: May 2022

Abstract

This book chapter discusses ants. Because ants live in large nests that can house many thousands to millions of individuals, their collective effect is certainly what causes greatest concern as a force that may destroy or consume large quantities of food or other materials important to humans. In nature, ants perform beneficial functions, preying on pests, aerating soils, moving soil nutrients, and decomposing organic matter, but in urban environments, they can be considered as one of the most destructive urban pests. Ants belong to the order Hymenoptera which also includes bees and wasps, and, like many other hymenopterans, they are social insects with colony duties divided among different castes. Although most ants can bite with their jaws, the ones that cause greater concern are the ones that sting, using a modified ovipositor to inflict pain. Emphasis should be on excluding ants from buildings and eliminating food and water sources. Ants undergo complete metamorphosis, having egg, larval, pupal, and adult stages. Ant management requires diligent effort and the combined use of mechanical, cultural, sanitation, and chemical methods of control.
A trade-off between the employment of older and younger workers? An historical approach to the political framing and reframing of labour market crowding out in the Dutch welfare state
Authors: Yerkes Mara A. , Lenitz Johanna , de Graaf-Zijl Marloes 
Published: May 2022

ABSTRACT
Against a background of population ageing, rising welfare state costs, and the potential for intergenerational conflict, there is continued belief in the unsubstantiated idea that older and younger workers crowd each other out in the labour market. Taking a longitudinal approach, we historically describe the framing and reframing of the idea of crowding out in Dutch political discourse between 1977–2017. Using a rich dataset of all political party manifestos for this period, we demonstrate the continued belief in employment as a zero-sum game, highlighting how this idea is politically framed and reframed against a backdrop of political and institutional welfare state development. These findings offer empirical evidence on an under-researched topic, providing insights into political and policymaking processes.