bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of Late-Life Sleep Medication Use With Incident Dementia in the Atherosclerosis Risk in Communities Study
Authors: Full Kelsie M , Pusalavidyasagar Snigdha , Palta Priya , Sullivan Kevin J , Shin Jung-Im , Gottesman Rebecca F , Spira Adam P , Pase Matthew P , Lutsey Pamela L 
Published: April 2022

AbstractBackgroundSleep medications may contribute to dementia development or indicate sleep disturbances that are markers of or contributors to neurologic disease. The objective of this study was to examine the use of sleep medications and incident dementia in a community-based cohort of older adults. We hypothesize late-life sleep medication use is associated with a greater risk of dementia.MethodsThe Atherosclerosis Risk in Communities (ARIC) study is an ongoing community-based cohort study. ARIC participants taking barbiturates, benzodiazepines, antidepressants, non-benzodiazepine receptor agonists (Z-drugs), or other hypnotics in 2011–2013 were categorized as sleep medication users. Participants were followed through 2019 for incident dementia. Logistic regression propensity scores were used to match sleep medication users with nonusers (1:2). Cox proportional hazards regression models were used to estimate hazard ratios (HR) for time to dementia diagnosis with adjustment for demographics, lifestyle characteristics, and cardiovascular risk factors.ResultsOne-quarter of the eligible ARIC participants used sleep medications. In the matched sample (N = 4 197; 69% female; mean age 75.3 + 5.0 years), 632 dementia cases were ascertained over a median follow-up of 6.5 years. In the fully adjusted model, sleep medication use compared to nonuse was associated with a 48% greater risk of dementia (HR: 1.48; 95% confidence interval (CI): 1.26–1.74).ConclusionTo expand on these findings, studies with longer follow-up and earlier assessment of sleep medication use are needed. Furthermore investigation of the potential dose-response association of multiple sleep medications and the potential causal role of sleep medications in the development of dementia may be clinically meaningful.
GALAXY ver3: updated web application for glycosylation profiling based on 3D HPLC map
Authors: Yagi Hirokazu , Amagasa Eijiro , Shiota Masaaki , Yamada Issaku , Aoki-Kinoshita Kiyoko F , Kato Koichi 
Published: April 2022

Abstract
High-performance liquid chromatography (HPLC) elution data provide a useful tool for quantitative glycosylation profiling, discriminating isomeric oligosaccharides. The web application Glycoanalysis by the Three Axes of MS and Chromatography (GALAXY), which is based on the three-dimensional HPLC map of N-linked oligosaccharides with pyridyl-2-amination developed by Dr. Noriko Takahashi, has been extensively used for N-glycosylation profiling at molecular, cellular, and tissue levels. Herein, we describe the updated GALAXY as version 3, which includes new HPLC data including those of glucuronylated and sulfated glycans, an improved graphical user interface using modern technologies, and linked to glycan information in GlyTouCan and the GlyCosmos Portal. This liaison will facilitate glycomic analyses of human and other organisms in conjunction with multiomics data.
Peptidoglycan from Akkermansia muciniphila MucT: chemical structure and immunostimulatory properties of muropeptides
Authors: Garcia-Vello Pilar , Tytgat Hanne L P , Gray Joe , Elzinga Janneke , Di Lorenzo Flaviana , Biboy Jacob , Vollmer Daniela , De Castro Cristina , Vollmer Waldemar , de Vos Willem M , Molinaro Antonio 
Published: April 2022

Abstract
Akkermansia muciniphila is an intestinal symbiont known to improve the gut barrier function in mice and humans. Various cell envelope components have been identified to play a critical role in the immune signaling of A. muciniphila, but the chemical composition and role of peptidoglycan (PG) remained elusive. Here, we isolated PG fragments from A. muciniphila MucT (ATCC BAA-835), analyzed their composition and evaluated their immune signaling capacity. Structurally, the PG of A. muciniphila was found to be noteworthy due of the presence of some nonacetylated glucosamine residues, which presumably stems from deacetylation of N-acetylglucosamine. Some of the N-acetylmuramic acid (MurNAc) subunits were O-acetylated. The immunological assays revealed that muropeptides released from the A. muciniphila PG could both activate the intracellular NOD1 and NOD2 receptors to a comparable extent as muropeptides from Escherichia coli BW25113. These data challenge the hypothesis that non-N-acetylattion of PG can be used as a NOD-1 evasion mechanism. Our results provide new insights into the diversity of cell envelope structures of key gut microbiota members and their role in steering host–microbiome interactions.
Age-friendliness of city, loneliness and depression moderated by internet use during the COVID-19 pandemic
Authors: Ng Siew-Imm , Lim Xin-Jean , Hsu Hui-Chuan , Chou Chen-Chen 
Published: April 2022

Summary
The purpose of this study was to examine the association between age-friendliness of a city, loneliness and depression moderated by internet use among older people during the coronavirus disease 2019 (COVID-19) pandemic. The survey was from ‘The 2020 Survey of Needs Assessment for a Safe Community and Age-Friendly City’ in Xinyi District, Taipei, which was conducted by face-to-face interviews with community-based older adults who were aged 65 and above from one district of Taipei City from May to June 2020 (n = 335). Partial least square structural equation modeling and the SPSS PROCESS macro were used for data analysis. Two domains of an age-friendly city (housing and community support and health services) were found to be associated with reduced loneliness, while one (respect and social inclusion) was associated with decreased depression. The age-friendliness of cities mitigates depression through moderator (internet use) and mediation (loneliness) mechanisms. Although some age-friendly domains of the city reduced loneliness and depression directly, the age-friendliness–loneliness-depression mechanism held true only for older adults who used the internet and not for nonusers. Maintaining the age-friendliness of an environment is beneficial to mental health, and internet use is a necessary condition to gain optimum benefits from age-friendly initiatives. Policy suggestions are discussed.
Health promotion strategies toward improved healthcare access for migrants and refugees in Europe: MyHealth recommendations
Authors: Evangelidou Stella , Schouler-Ocak Meryam , Movsisyan Narine , Gionakis Nikos , Ntetsika Maria , Kirkgoeze Nur , Denial Abdallah , Serre-Delcor Nuria 
Published: April 2022

Summary
MyHealth European project (2017–2020) was committed to elaborate on models to engage vulnerable migrants and refugees (VMR) in their health through community involvement. Low healthcare access and poor quality of healthcare services for VMR is a common reality in many European countries. The purpose of the present study, as part of MyHealth project, was the development of an agenda for actions and consequent recommendations to tackle the issue. A qualitative research design was applied at four study sites in Barcelona, Spain; Berlin, Germany; Brno, Czech Republic and Athens, Greece. The Metaplan® group discussions allowed the collection, organization and process of ideas and opinions elaborated in the collaborative groups. In total, 14 sessions took place: 4 with health and social professionals (n = 41) and 10 with VMR (n = 77). A participatory thematic analysis was performed at every session and overall for all sessions a thematic analysis synthesized the findings. The suggested actions were divided into two levels of recommendations: (i) local authorities at destination country-related, such as the investment in health professionals’ cultural competences, and (ii) VMR-related, such as adaptation of help-seeking behavior patterns. Special attention was proposed to women survivors of violence and homeless minors. The study concluded to an agenda for action in Europe. We advocate for a public health paradigm shift where, while holding a bottom-up approach, VMR as well as professionals working with them are actively and meaningfully engaged in the decision-making process of access-enhancing and health promotion strategies in a given socio-cultural context.
Pathological characterization of a novel mouse model expressing the PD-linked CHCHD2-T61I mutation
Authors: Kee Teresa R , Wehinger Jessica L , Gonzalez Pamela Espinoza , Nguyen Eric , McGill Percy Kyle C , Khan Sophia A , Chaput Dale , Wang Xinming , Liu Tian , Kang David E , Woo Jung-A A 
Published: April 2022

Abstract
Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) is a mitochondrial protein that plays important roles in cristae structure, oxidative phosphorylation and apoptosis. Multiple mutations in CHCHD2 have been associated with Lewy body disorders (LBDs), such as Parkinson’s disease (PD) and dementia with Lewy bodies, with the CHCHD2-T61I mutation being the most widely studied. However, at present, only CHCHD2 knockout or CHCHD2/CHCHD10 double knockout mouse models have been investigated. They do not recapitulate the pathology seen in patients with CHCHD2 mutations. We generated the first transgenic mouse model expressing the human PD-linked CHCHD2-T61I mutation driven by the mPrP promoter. We show that CHCHD2-T61I Tg mice exhibit perinuclear mitochondrial aggregates, neuroinflammation, and have impaired long-term synaptic plasticity associated with synaptic dysfunction. Dopaminergic neurodegeneration, a hallmark of PD, is also observed along with α-synuclein pathology. Significant motor dysfunction is seen with no changes in learning and memory at 1 year of age. A minor proportion of the CHCHD2-T61I Tg mice (~10%) show a severe motor phenotype consistent with human Pisa Syndrome, an atypical PD phenotype. Unbiased proteomics analysis reveals surprising increases in many insoluble proteins predominantly originating from mitochondria and perturbing multiple canonical biological pathways as assessed by ingenuity pathway analysis, including neurodegenerative disease-associated proteins such as tau, cofilin, SOD1 and DJ-1. Overall, CHCHD2-T61I Tg mice exhibit pathological and motor changes associated with LBDs, indicating that this model successfully captures phenotypes seen in human LBD patients with CHCHD2 mutations and demonstrates changes in neurodegenerative disease-associated proteins, which delineates relevant pathological pathways for further investigation.
Anticorruption and Transitional Justice: A Distinction Without a Difference
Authors: Michalakea Taygeti 
Published: April 2022

Abstract
Anticorruption efforts in the framework of transitional justice seemingly insert the missing ‘economic’ link and are thus considered to modify its mainstream paradigm and diversify its politics. This article counter argues that, instead, anticorruption efforts reinforce the problematic points and invisibilities of transitional justice and further embed a liberal conceptualization of it. Using the case study of Tunisia, the article contends that anticorruption efforts stepped onto the footprints of the paradigmatic transitional toolbox by decontextualizing and depoliticizing their object of intervention, effectively foreclosing any meaningful engagement with the past, and validating liberal economic agendas in the process.
Year-round genetic monitoring of mixed-stock fishery of Atlantic cod (Gadus morhua); implications for management
Authors: Christensen Helle Torp , Rigét Frank , Retzel Anja , Nielsen Erik Haar , Nielsen Einar Eg , Hedeholm Rasmus Berg 
Published: April 2022

Abstract
Mixed-stock fisheries pose a challenge for fisheries management recommendations and management, as mixed stocks can lead to unintentional over- or under-exploitation of stocks, with both short- and long-term biological and economic consequences. This study demonstrates practical application and implementation of year-round high-resolution genetic stock monitoring in management of mixed Atlantic cod (Gadus morhua) stocks in western Greenland. Using a panel of 96 high resolution gene-associated SNPs, we identified the stock of origin for four cod stocks in the two major inshore mixed-stock fisheries. Contribution of individual stocks was quantified to identify if fjord sections, times of year, and fish size, would allow a “clean fishery” with a minimal contribution of the depleted West Greenland Offshore (WGO) population. High level of mixing was identified with 50% of inshore catches originating from the inshore stock, 20% from the East Greenland/Iceland offshore stock, and 30% from the WGO stock. Although some spatiotemporal variation of stock proportions was identified, a practice allowing exclusively fishing a specific stock was not possible. Accordingly, we demonstrate the need to allocate catches at the biological stock level and show that application of high-resolution genetics is a reliable and necessary tool.
Rights-based constitutionalism and gender justice in Colombian women’s soccer
Authors: Dávila María Ximena , Chaparro Nina , Sánchez Nelson Camilo 
Published: April 2022

Abstract
This article queries whether domestic rights protection systems offer the necessary opportunities for women soccer players to obtain improved conditions through courts. Zooming in on the Colombian Constitutional Court jurisprudence, the article evaluates the potential benefits that rights-based constitutionalism can bring to those who fight for gender equality in the practice of football. Our assessment concludes that there are compelling opportunities, but they come with significant challenges. As for opportunities, we highlight the active role of the Constitutional Court in the protection of rights. On the other hand, the main challenges call for strengthening the nascent social movement that supports women’s demands in soccer and diversifying the avenues for vindicating rights. Activists could achieve better opportunities for justice by combining constitutional litigation with other forms of mobilization.
Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study
Authors: Zhou Ang , Hyppönen Elina 
Published: April 2022

Abstract

Background
Low vitamin D status is often associated with systemic low-grade inflammation as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and direction of the association between vitamin D status and CRP using linear and non-linear Mendelian randomization (MR) analyses.

Methods
MR analyses were conducted using data from 294 970 unrelated participants of White-British ancestry from the UK Biobank. Serum 25-hydroxyvitamin D [25(OH)D] and CRP concentrations were instrumented using 35 and 46 genome-wide significant variants, respectively.

Results
In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (&lt;25 nmol/L) and levelled off at ∼50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4). Analyses using several pleiotropy-robust methods provided consistent results in stratified MR analyses, confirming the inverse association between 25(OH)D and CRP in the deficiency range (P = 1.10E-05) but not with higher concentrations. Neither linear or non-linear MR analysis supported a causal effect of serum CRP level on 25(OH)D concentration (Plinear = 0.32 and Pnon-linear = 0.76).

Conclusion
The observed association between 25(OH)D and CRP is likely to be caused by vitamin D deficiency. Correction of low vitamin D status may reduce chronic inflammation.
Research on offshore wind power system based on Internet of Things technology
Authors: Zhou Fen , Tu Xuping , Wang Qingdong 
Published: April 2022

Abstract
Wind power generation is considered as one of the very promising new energy power generation methods. Offshore wind farms are usually located in open spaces far from the coast, where the wind is strong enough to generate electricity efficiently and reliably. The operation and maintenance of offshore wind power generation is more important; it will greatly affect the life cycle cost, although it is more difficult. Different from the methods used in other papers, this paper uses the Internet of Things (IOT) technology to collect and analyze wind power generation data to accurately and efficiently realize the operation and maintenance of offshore wind power generation. This paper also establishes an economic model for further analysis. Estimated electricity production under real weather is integrated into the model. According to the estimated model, with IOT technology can reduce maintenance costs by ~75% compared to without IOT technology, and according to our operation and maintenance data, we found that the downtime caused by blades, gearboxes and generators accounted for more than 87% of the total unplanned downtime, and maintenance costs accounted for more than three-fourths of the total maintenance costs. These data have reference significance for the operation and maintenance of offshore wind power generation.
Formal and informal medicine retailers in Sub-Saharan Africa: a scoping review of research trends
Authors: Oleffe Amandine , Sako Binta , Paul Elisabeth , Mahieu Céline 
Published: April 2022

AbstractObjectivesIn Sub-Saharan Africa (SSA), private medicine retailers have become the first entry point to health systems, irrespective of their level of accreditation. This review aims to map the main trends in research about formal and informal medicine retailers in SSA over the past 20 years. Such an overview offers a valuable resource to understand their role and develop inclusive interventions to improve accessibility to health care in line with people’s health-seeking behaviours. This review followed the steps recommended by the Joanna Briggs Institute. Four electronic databases were searched and complemented by manual web researches.Key FindingsA total of 293 publications from 23 countries met our inclusion criteria, 79% of which relate to six countries. The number of publications has been growing since 2010. Medicine retailers are distributed among three professional groups based on their accreditation level. Most studies used quantitative methods. Three topics − service provision; knowledge, attitudes and practices; and the expanding role of medicine retailers in the health system – accounted for 67% of included studies. Most studies focus on a specific health condition, of which malaria (26%) and sexual/reproductive health (13%) are the most common.SummaryThis review reveals increasing interest in medicine retailers in SSA and increasing expectations as stakeholders within health systems. This review suggests that new research and interventions should focus on: moving beyond a disease-based approach; using qualitative methods; and understudied countries, rural areas and informal medicine retailers. A more dynamic, relational and interactive approach could help better understand the sector.
Construction and application of provable positive and exact cubature formulas
Authors: Glaubitz Jan 
Published: April 2022

Abstract
Many applications require multi-dimensional numerical integration, often in the form of a cubature formula (CF). These CFs are desired to be positive and exact for certain finite-dimensional function spaces (and weight functions). Although there are several efficient procedures to construct positive and exact CFs for many standard cases, it remains a challenge to do so in a more general setting. Here, we show how the method of least squares (LSs) can be used to derive provable positive and exact formulas in a general multi-dimensional setting. Thereby, the procedure only makes use of basic linear algebra operations, such as solving an LSs problem. In particular, it is proved that the resulting LSs CFs are ensured to be positive and exact if a sufficiently large number of equidistributed data points is used. We also discuss the application of provable positive and exact LSs CFs to construct nested stable high-order rules and positive interpolatory formulas. Finally, our findings shed new light on some existing methods for multi-variate numerical integration and under which restrictions these are ensured to be successful.
Compactness of Solutions to Higher-Order Elliptic Equations
Authors: Niu Miaomiao , Tang Zhongwei , Zhou Ning 
Published: April 2022

Abstract
We use blow up analysis for local integral equations to prove compactness of solutions to higher-order critical elliptic equations provided the potentials only have non-degenerate zeros. Secondly, corresponding to Schoen’s Weyl tensor vanishing conjecture for the Yamabe equation on manifolds, we establish a Laplacian vanishing rate of the potentials at blow up points of solutions.
Extra Connected Components in the Moduli Space of Stable Surfaces
Authors: Rollenske Sönke 
Published: April 2022

Abstract
We construct examples of non-smoothable stable surface with invariants in a wide range comprising all possible invariants of smooth minimal surfaces of general type but non-standard second plurigenus. We deduce that the moduli space of stable surfaces $\overline {{\mathfrak {M}}}_{k,l}$ has at least $k-l+2$ connected components distinguished by the second plurigenus and, in particular, always has more irreducible components than the Gieseker moduli space with the same invariants.
A Geometrical View of Ulrich Vector Bundles
Authors: Lopez Angelo Felice , Sierra José Carlos 
Published: April 2022

AbstractWe study geometrical properties of an Ulrich vector bundle ${\mathcal {E}}$ of rank $r$ on a smooth $n$-dimensional variety $X \subseteq {\mathbb {P}}^N$. We characterize ampleness of ${\mathcal {E}}$ and of $\det {\mathcal {E}}$ in terms of the restriction to lines contained in $X$. We prove that all fibers of the map $\Phi _{{\mathcal {E}}}:X \to {\mathbb G}(r-1, {\mathbb {P}} H^0({\mathcal {E}}))$ are linear spaces, as well as the projection on $X$ of all fibers of the map $\varphi _{{\mathcal {E}}}: {\mathbb {P}}({\mathcal {E}}) \to {\mathbb {P}} H^0({\mathcal {E}})$. Then we get a number of consequences: a characterization of bigness of ${\mathcal {E}}$ and of $\det {\mathcal {E}}$ in terms of the maps $\Phi _{{\mathcal {E}}}$ and $\varphi _{{\mathcal {E}}}$; when $\det {\mathcal {E}}$ is big and ${\mathcal {E}}$ is not big there are infinitely many linear spaces in $X$ through any point of $X$ and when $\det {\mathcal {E}}$ is not big, the fibers of $\Phi _{{\mathcal {E}}}$ and $\varphi _{{\mathcal {E}}}$ have the same dimension; a classification of Ulrich vector bundles whose determinant has numerical dimension at most $\frac {n}{2}$; and a classification of Ulrich vector bundles with $\det {\mathcal {E}}$ of numerical dimension at most $k$ on a linear ${\mathbb {P}}^k$-bundle.