bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causal relationship between allergy and seborrheic dermatitis
Authors: Barilo A. A. , Smirnova S. V. 
Published: July 2022

Seborrheic dermatitis is a chronic relapsing inflammatory skin disease associated with overproduction of sebum and activation of the fungal skin microbiota characterized by the presence of erythematous pruritic patches and plaques with greasy scales in areas rich in sebaceous glands.Aim. To study the spectrum of sensitization to food, pollen, and indoor and fungal allergens in patients with seborrheic dermatitis.Materials and methods. The study researched features of the spectrum of sensitization to food, pollen, and fungal and indoor allergens in patients with seborrheic dermatitis (n = 40, aged 15–59 years) based on the data of an objective examination and the results of an allergen-specific test, including skin prick testing.Results. It was determined that the most significant food allergens in seborrheic dermatitis are chicken eggs and grains. The incidence of polyvalent sensitization to food allergens was 40.0%. Additionally, high incidence of sensitization to pollen allergens, most often to weed and poaceae pollen, was revealed in patients with seborrheic dermatitis. Among indoor allergens, the highest incidence of sensitization was determined to house dust and Dermatophagoides pteronyssinus. Among fungal allergens, the highest incidence of sensitization was detected to Candida albicans. Conclusion. It was found that patients with seborrheic dermatitis are often sensitized to food, pollen, and indoor and fungal allergens. Therefore, allergy can be considered a risk factor for the development of pathology.
Screening of local hyaluronic acid injection modes to increase the efficiency of treating crush injury of soft tissues
Authors: Shperling I. A. , Shulepov A. V. , Shperling N. V. , Kuzmina O. Yu. 
Published: July 2022

Aim. To study the state of microcirculation and metabolic activity of the soft tissues in the compression area in experimental crush injury after local hyaluronic acid injection and to determine the effective mode of its application.Materials and methods. The experiments were carried out on 178 male Wistar rats aged 4–4.5 months and weighing 280–340 g. The study design included anesthesia, modeling of crush injury (CI), local injection of 1.75% hyaluronic acid (HA) solution into the compression area, systemic intravenous injection of 0.9% sodium chloride solution daily for 3 days, and a study of microcirculation and metabolism of the soft tissues in the damaged area 3, 7, 14, and 28 days after the injury.Results. Early (3 hours after the injury) local application of HA for CI improved microcirculation, increased oxygen consumption, and activated oxidative metabolism in the skeletal muscles, which helped reduce the severity of destructive processes in the damaged area. The most effective injection mode was two-fold administration of HA: 3 hours after the compression cessation and additionally 24 hours after the injury.Conclusion. In the crush injury, early local intramuscular injection of HA into the damaged area in the first few hours after the cessation of compression is a sanogenetically substantiated method for correcting traumatic ischemia of the muscles.
Features of vasoactive substance regulation in chorionic villi in women with spontaneous abortion and active cytomegalovirus infection
Authors: Andrievskaya I. A. , Ishutina N. N. , Dovzhikova I. V. , Prikhodko N. G. , Kutepova O. L. 
Published: July 2022

The aim of the study was to assess the levels of soluble fms-like tyrosine kinase 1 (sFlt1), placental growth factor (PlGF), and vascular endothelial growth factor A (VEGF-A) in tissue extracts in comparison with the histologic examination of the endometrium and chorionic villi in women with spontaneous abortion and active cytomegalovirus (CMV) infection.Materials and methods. 81 women at 7–9 weeks of pregnancy were examined: of them, 51 women were CMVseropositive with active infection and after spontaneous abortion, and 30 patients were CMV-seronegative, healthy women after therapeutic abortion. Immunoglobulins (Ig) M and G to CMV and CMV IgG avidity were measured in the blood plasma; sFlt1, PlGF, and VEGF-A were determined in extracts of chorionic villi by enzyme immunoassay. CMV DNA was detected in mononuclear cells of peripheral blood, urine, and chorionic villi by real-time polymerase chain reaction (PCR). A histologic examination of the endometrium and chorionic villi was carried out.Results. In chorionic villus extracts of women with spontaneous abortion and active CMV infection, the concentration of sFlt1 was 3.25 times higher (p < 0.001), and the levels of PlGF and VEGF-A were 1.31 (p < 0.001) and 2.16 times lower (p < 0.001) than in healthy women. A strong negative correlation was established between the levels of sFlt1 and PlGF (r = –0.702; p < 0.001) and VEGF-A (r = –0.858; p < 0.0005), and a positive correlation was revealed between PlGF and VEGF-A levels (r = 0.860; p < 0.001). According to the data of the histologic examination, a lag in decidual transformation of uterine vessels, trophoblast invasion, growth and differentiation of villi, and formation of fetal circulation was detected.Conclusion. The mechanisms of spontaneous abortion in women with active CMV infection include an imbalance of pro- and anti-angiogenic factors, which causes impaired placental development and uteroplacental circulation.
Evaluation of the cytotoxic activity and toxicity of a tropolone derivative with a potential antitumor effect
Authors: Kit O. I. , Minkin V. I. , Lukbanova E. A. , Sayapin Yu. A. , Gusakov E. A. , Sitkovskaya A. O. , Filippova S. Yu. , Komarova E. F. , Volkova A. V. , Khodakova D. V. , Mindar M. V. , Lazutin Yu. N. , Engibaryan M. A. , Kolesnikov V. E. 
Published: July 2022

The aim. To study the toxicity of 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)-5,6,7-trichloro-1,3-tropolone in vitro and in vivo.Materials and methods. 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)-5,6,7-trichloro-1,3-tropolone was synthesized using a method for expanding the o-quinone cycle during the reaction between 5-nitro-2,6,8-trimethyl4-chloroquinoline and 3,4,5,6-tetrachloro-1,2-benzoquinone while boiled in dioxane. An in vitro experiment was carried out in the human A549 cell line. Cell viability was assessed using the MTT colorimetric assay by reducing the optical density of the experimental samples compared with the control ones. Acute toxicity was studied on 20 BALB/c Nude male mice. The test compound was administered once orally as a suspension in 1% starch gel at three doses: 0.0055 (group 1), 0.055 (group 2) and 0.55 mg / g (group 3). The control group (group 4) received a placebo.Results. We synthesized a new compound, 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)-5,6,7-trichloro-1,3-tropolone. Its structure was established by 1 H nuclear magnetic resonance (NMR), infrared (IR) spectroscopy, and mass spectrometry. The yield was 19.8 g (52%), the melting point was 205–207 ºС, bright yellow crystals (benzene) were observed. The half-maximal inhibitory concentration (IC50) of 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)-5,6,7-trichloro-1,3-tropolone was 0.21 ± 0.01 μM, which was significantly lower (р < 0.05) than the IC50 of cisplatin (3.84 ± 0.23). Following the in vivo experiment, no toxic effect of tropolone was detected when administered once at a dose of 0.0055, 0.055, and 0.55 mg / g. Conclusion. 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)-5,6,7-trichloro-1,3-tropolone demonstrated cytotoxic effects on the A549 cell line at a lower IC50 than cisplatin which is widely used in treatment of cancers, including lung cancer. Insolubility of 2-(6,8-dimethyl-5-nitro-4-chloroquinoline-2-yl)-5,6,7-trichloro-1,3-tropolone in water and the absence of its toxic effect in the studied modes determine the scope of its application for further study of cumulative and antitumor effects.
Does Value-Based Care Threaten Joint Arthroplasty Access for Vulnerable Patient Populations?
Authors: Lin Eugenia , Bozic Kevin J. , Ibrahim Said , O’Connor Mary I. , Nelson Charles L. 
Published: July 2022

Abstract:
Health-care expenses have been projected to increase from 17.7% of the U.S. gross domestic product (GDP) in 2014 to 19.6% in 2024. The unsustainable increase in health-care costs has contributed toward support for value-based health care (VBHC) reform. Contemporary VBHC reform programs relevant to orthopaedic surgery include the voluntary Bundled Payments for Care Improvement initiatives (BPCI and BPCI-Advanced) and the Comprehensive Care for Joint Replacement (CJR) program, a mandatory bundled payment program.
The purported benefits of transitioning from volume-based reimbursement to value-based reimbursement include moving from a fragmented provider-centered care model to a patient-centered model, with greater care coordination and alignment among providers focused on improving value. VBHC models allow innovative strategies to proactively invest resources to promote value (e.g., the use of nurse navigators) while eliminating unnecessary resources that do not promote value. However, major concerns regarding VBHC include the absence of medical and socioeconomic risk stratification as well as decreased access for higher-risk patients.
This article identifies the benefits and potential unintended consequences of VBHC reform, with a focus on joint arthroplasty. We also discuss some potential strategies to promote innovation and improve value without compromising access for vulnerable patients.
Spontaneous Lumbar Curve Correction Following Vertebral Body Tethering of Main Thoracic Curves
Authors: Catanzano Anthony A. , Newton Peter O. , Bastrom Tracey P. , Bartley Carrie E. , Parent Stefan , Miyanji Firoz , Hoernschemeyer Daniel G. , Alanay Ahmet , Blakemore Laurel , Neal Kevin , Lonner Baron , Haber Lawrence , Shah Suken A. , Yaszay Burt ,   on behalf of the Harms Non-Fusion Study Group Investigators
Published: July 2022

Background:
Growth modulation through anterior vertebral body tethering (AVBT) has emerged as a fusionless option for the treatment of progressive scoliosis. When tethering the main thoracic curve, the compensatory thoracolumbar/lumbar curve must correct indirectly as a result. The present study evaluated the response of these lumbar curves following AVBT of the main thoracic curves.

Methods:
Patients who underwent thoracic AVBT and who had a minimum follow-up of 2 years were included. Magnitudes of the thoracic and lumbar curves were recorded preoperatively and at the first-erect and 2-year postoperative visits. Lumbar curves were further stratified according to their lumbar modifier (A, B, or C). Analysis of variance (ANOVA) and repeated-measures ANOVA were performed to compare correction rates, and the Pearson coefficient was utilized to determine the correlation between the tethered thoracic curve and uninstrumented lumbar curve magnitudes.

Results:
A total of 218 patients were included. Thoracic curve correction was 40% at the first-erect visit and 43% at 2 years (p = 0.012). Lumbar correction was 30%, 26%, and 18% at the first-erect visit (p < 0.001 for all compared with preoperatively) and minimally changed at 31%, 26%, and 24% at 2 years for lumbar modifiers A, B, and C, respectively. A total of 118 patients (54%) showed thoracic curve improvement between the first-erect and 2-year visits. In a subgroup analysis, these patients had a correction in lumbar curve magnitude from preoperatively to the first-erect visit of 30%, 22%, and 16% for lumbar modifiers A, B, C, respectively, that increased to 42%, 34%, and 31% at 2 years, with strong correlation to thoracic correction at 2-year follow-up (r = 0.557, p < 0.001).

Conclusions:
Although there was immediate lumbar correction following AVBT of a main thoracic curve, further improvement following initial correction was only observed among patients with growth modulation of the thoracic curve. Considering all patients, the uninstrumented lumbar curve corrected 30% at 2 years and the instrumented thoracic curve corrected 40%. As indications for AVBT are refined, these data will provide insight into the response of the uninstrumented lumbar curve.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Seroprevalence, trends, and risk factors of hepatitis B and C among family replacement blood donors; a 7-year retrospective study at Sunyani Municipal Hospital, Ghana
Authors: Osei-Boakye Felix , Nkansah Charles , Appiah Samuel Kwasi , Derigubah Charles Angnataa , Mensah Kofi , Apandago Abraham Azumah , Boateng Vida Animah , Norsi Obed Gadufia , Kogh-Nuu Dominic 
Published: July 2022

Abstract
Background
Hepatitis B and C cause chronic infections which develop into liver-related sequelae, like cirrhosis and liver carcinoma. This study determined the prevalence, trends, and risk factors of HBV and HCV among family replacement blood donors.
Methods
A retrospective review of primary data on blood donors screened between January 2015 and December 2021 was conducted at the Sunyani Municipal Hospital. The data were assessed for seroprevalence, trends, and odds ratios using SPSS.
Results
Of 6847 donors, the majority were males (88.1% [6033]), ≤ 24 years (27.4% [1874]), of the O blood type (69.8% [4776]), and Rh-positive (89.9% [6154]). Seroprevalences of HBV and HCV were 3.2% and 1.9%, respectively, with more males infected with both HBV and HCV (3.4% vs 2.0%). Male donors were 2.842 times (CI: 1.500-5.385, p = 0.001) and 2.399 times (CI: 1.116–5.157, p = 0.025) more susceptible than females to HBV and HCV, respectively. In the rainy season, donors were 1.489 times (CI: 1.017–2.180, p = 0.041) more susceptible to HCV. HBV and HCV showed declining trends over the period (slope: -0.5464, p ≤ 0.001 vs slope: -0.6179, p ≤ 0.001).
Conclusion
Gender was significantly associated with both HBV and HCV, while season was significantly associated with HCV. The male gender and rainy season were significant determinants of both infections. The seroprevalence of HBV was higher than HCV despite the significant decline in both HBV and HCV seroprevalences. We, recommend health authorities intensify health education among males and during the rainy season. Also, local variations in the seroprevalence of these infections call for upgrade and standardisation in serological testing for blood donors across Ghanaian blood centres.
Comparison of Total and Hidden Blood Loss in Patients Undergoing Single-Level Open and Unilateral Biportal Endoscopic Transforaminal Lumbar Interbody Fusion
Authors: Peng Yu-jian , Fan Zhi-ying , Wang Qian-liang , Dai Jun , Zhang Qian-zhong-yi , Cao Jun-yin , Liu Xiao-feng , Yan Jun 
Published: July 2022

Abstract
urpose: This study aimed to compare total blood loss (TBL) and hidden blood loss (HBL) in patients undergoing single-level open transforaminal lumbar interbody fusion (O-TLIF) and unilateral biportal endoscopic transforaminal lumbar interbody fusion (ULIF).Methods: A total of 28 patients who underwent ULIF and 30 patients who underwent O-TLIF from March 2020 to October 2021 were retrospectively reviewed. The Nadler’s formula was employed to estimate the patient’s blood volume (PBV), Gross’s formula to estimate TBL, and Sehat’s formula to estimate HBL. The obtained data were then analyzed with independent t test、chi-squared test, and analysis of covariance.Results: TBL and measured blood loss (MBL) in ULIF group (360.00±245.74 ml, 117.43±83.09 ml) was significantly lower than O-TLIF group (542.29±233.25ml, 306.30±108.98ml). Nevertheless, the HBL in ULIF group was higher than that in O-TLIF group (242.57±242.49 ml vs 235.99±236.53 ml), however this was not statistically significant. (P=0.917). The HBL was 67.38± 25.63% of TBL in ULIF group and 43.52±17.39% of TBL in O-TLIF group. Patients in ULIF group had lower TBL and MBL, shorter duration of drainage, lower postoperative anemia, and shorter postoperative hospital stay compared to those in O-TLIF group.Conclusions: Perioperative HBL should not be neglected in patients undergoing ULIF or O-TILF, as it accounts for a large percentage of TBL in both groups. ULIF is associated with lower TBL and MBL, postoperative anemia, shorter postoperative hospital stays compared with O-TLIF.
TEDC2 correlated with prognosis and immune microenvironment in lung adenocarcinoma
Authors: Fang Likui , Yu Wenfeng , Zhu Pengfei , Yu Guocan , Ye Bo 
Published: July 2022

Abstract
Tubulin epsilon and delta complex 2 (TEDC2) is a protein coding gene which function is poorly identified yet. This study aimed to identify the role of TEDC2 in prognosis and immune microenvironment of lung adenocarcinoma (LUAD). Through The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, the mRNA expression of TEDC2 was upregulated in LUAD tissues compared to normal tissues. The protein level of TEDC2 was also higher in LUAD in the Human Protein Atlas. The receiver operating characteristic (ROC) curve showed that high TEDC2 level could distinguish LUAD patients from normal subjects. In addition, the impact of TEDC2 expression on prognosis was evaluated by Kaplan-Meier and Cox regression analyses, and the results suggested that high TEDC2 expression was significantly associated with poor prognosis and was the independent prognostic factor in LUAD. GO and KEGG pathway analyses indicated the co-expressed genes of TEDC2 were mainly related to mitotic cell cycle processes. Importantly, high expression of TEDC2 indicated low infiltration of immune cells, especially dendritic cells and B cells. TEDC2 was also positively correlated with immune checkpoints such as PDCD1, LAG3 and CD276. Taken together, this study preliminarily revealed the clinical significance of TEDC2 in LUAD and provided novel insights into the role of TEDC2 in immune microenvironment.
Fitness Dependent Optimizer for IoT Healthcare using Adapted Parameters: A Case Study Implementation
Authors: Aladdin Aso M. , Abdullah Jaza M. , Salih Kazhan Othman Mohammed , Rashid Tarik A. , Sagban Rafid , Alsaddon Abeer , Bacanin Nebojsa , Chhabra Amit , Vimal S. , Banerjee Indradip 
Published: July 2022

Abstract
This discusses a case study on Fitness Dependent Optimizer or so-called FDO and adapting its parameters to the Internet of Things (IoT) healthcare. The reproductive way is sparked by the bee swarm and the collaborative decision-making of FDO. As opposed to the honey bee or artificial bee colony algorithms, this algorithm has no connection to them. In FDO, the search agent's position is updated using speed or velocity, but it's done differently. It creates weights based on the fitness function value of the problem, which assists lead the agents through the exploration and exploitation processes. Other algorithms are evaluated and compared to FDO as Genetic Algorithm (GA) and Particle Swarm Optimization (PSO) in the original work. The key current algorithms—The Salp-Swarm Algorithms (SSA), Dragonfly Algorithm (DA), and Whale Optimization Algorithm (WOA) have been evaluated against FDO in terms of their results. Using these FDO experimental findings, we may conclude that FDO outperforms the other techniques stated. There are two primary goals for this chapter: first, the implementation of FDO will be shown step-by-step so that readers can better comprehend the algorithm method and apply FDO to solve real-world applications quickly. The second issue deals with how to tweak the FDO settings to make the meta-heuristic evolutionary algorithm better in the IoT health service system at evaluating big quantities of information. Ultimately, The target of this chapter's enhancement is to adapt the IoT healthcare framework based on FDO to spawn effective IoT healthcare applications for reasoning out real-world optimization, aggregation, prediction, segmentation, and other technological problems.
Contrast-enhanced MRI in women with endometrial cancer: dynamic versus single-phase acquisitions
Authors: Lee Myoung Seok , Moon Min Hoan , Kim Taek Min , Jang Siwon , Oh Sohee , Cho Jeong Yeon 
Published: July 2022

Abstract
Background: The 2019 ESUR guidelines for endometrial cancer recommend performing either dynamic contrast-enhanced MRI (CE MRI) or single-phase CE MRI. However, no study has directly compared these options. Therefore, this study compared dynamic versus single-phase CE MRI for the evaluation of myometrial invasion in women with endometrial cancer.Methods: This retrospective, single-institution comparative study was conducted among women with surgically proven endometrial cancer, including 30 consecutive women with single-phase CE MRI and 30 age- and pathologic stage-matched women with dynamic CE MRI. Three readers independently compared dynamic and single-phase CE MRI in terms of the tumor-myometrium signal intensity (SI) difference ratio, depth of myometrial invasion, image quality, and image number. Pathologic findings served as a reference standard for the depth of myometrial invasion.Results. The estimated mean SI difference ratios of dynamic CE MRI and single-phase CE MRI fell within an equivalence margin of 0.05 (90% confidence intervals; -0.0497 to 0.0165, -0.0226 to 0.0403, -0.0429 to 0.0433, respectively, for readers A, B, and C). The area under the receiver operating characteristic curve for the detection of deep myometrial invasion was not significantly different between the acquisitions (P=0.3315, P=0.3345, and P=0.8593, respectively). Single-phase CE MRI showed significantly better image quality than dynamic CE MRI (P=0.0143, P=0.0042, and P=0.0066, respectively), while the median number of images for dynamic CE MRI was 2.4 times higher than that for single-phase CE MRI.Conclusions. Single-phase acquisition may be a better option for CE MRI in women with endometrial cancer than dynamic acquisition.
Genetic services in a resource-constrained African setting – diagnostic odysseys, limited testing strategies and the need for exome sequencing
Authors: Wiener Emma , Buchanan James , Lombard Zane , Krause Amanda 
Published: July 2022

Abstract
Background: Exome sequencing is recommended as a first-line investigation for the diagnosis of developmental disorders (DD). It is uncertain if this recommendation can be translated to a low-resource setting, due to a dearth of research into current diagnostic practices in such settings.Results: A file audit performed on 934 patients presenting to a medical genetics clinic in South Africa showed that 83% of patients presented with DD. Patients could be divided into three groups, representing distinct diagnostic pathways. Patient Group A (18%; mean test cost $131) had genetically confirmed aneuploidies. Patient Group B (25%; mean test cost $140) presented with clinically recognizable conditions however only 39% received a genetic diagnostic confirmation. Patient Group C – the largest group (57%; mean test cost $337) – presented with rare, less recognizable conditions and 92% remained undiagnosed after available testing was performed.Conclusions: Patients with DD are the largest group of patients seen in medical genetics clinics in South Africa. Diagnostic testing approaches are limited, so where clinical features are not distinct, the diagnostic yield is low. A significant proportion of these patients would benefit from first-line exome sequencing, from a time, diagnosis and cost perspective, reducing their individual diagnostic odysseys.