bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptome analysisand development of SSR markers in Sumac (Rhus coriariaL.), and population structure analysis of sumac in Turkey
Authors: Gürcan Kahraman , Kılınçer İlyas , Khanyile Lungelo 
Published: July 2022

Abstract
Sumac ( Rhus coriaria L.) is known for medicinal properties since at least the time of Theophrastus in the ancient Graeco-Roman time. Indeed, in the last decade, vast number of scientific papers demonstrated the benefits of multifunctional sumac in pharmaceutical, food, and textile industries. However, genetic and genomic information is scarce for sumac. In this study, RNA-seq transcriptome data consisting of 72,554 unigenes with an average length of 869 nt was produced for sumac. The transcripts were considered for further downstream analysis of GO, COG, and KEGG. The sumac transcripts showed highest mapping rate to pistachio genome (97%) followed by poison ivy (95%) and mango (91%). In total, 11.177 SSR loci di-, tri- tetra-, penta-, and hexa-nucleotide motif loci with minimum of 5 repeats were identified. Phylogenetic and structure analysis of 64 sample collected from a wide geographic region in Turkey were studied with eight polymorphic SSR loci. Structure analysis showed existence of two sub-populations in sumac in Turkey. The bushes located in residential areas and used for sumac production were found to be genetically unique as so non-residential bushes. This demonstrates that sumac growing since ancient time has not resulted in selection of superior cultivar, followed by clonal propagation and transfer of clones between territories.
The effect of intravenous milrinone in adult critically ill patients: a meta-analysis of randomized clinical trials
Authors: Xu Jingyuan , Zhang Yanjie , Jiang Jie , Yang Yi , Guo Fengmei 
Published: July 2022

Abstract
Background
Milrinone is widely used for enhancing myocardial contractility, however, there is inadequate data to suggest it is preferable to other inotropic agents. To observe the effect of milrinone on prognosis in adult critically ill patients, we conducted this meta-analysis.
Methods
A search of the following databases was conducted: Medline, Elsevier, Cochrane Central Register of Controlled Trials and Web of Science databases, and eligible randomized controlled trials including adult critically ill patients were screened. Two reviewers collected data separately, information was retrieved including study design, center number, sample size, gender, age, intervention and outcome. Data were analyzed using methods recommended by the Cochrane Collaboration Review Manager 4.2 software. Random errors were evaluated by trial sequential analysis (TSA).
Results
Twenty studies including 2036 patients compared milrinone with control group were enrolled. When compared to control group, the incidence of ventricular arrhythmia decreased significantly in milrinone group in patients with cardiac surgery, but not in patients with cardiac dysfunction and shock. There was no significant reduction in the incidence of myocardial infarction, all-cause mortality and no improvement of hemodynamic paramenters in the milrinone group. TSA indicated lack of firm evidence for a beneficial effect.
Conclusions
The meta-analysis showed when compared with control group, the incidence of ventricular arrhythmia decreased significantly in patients with cardiac surgery, but not in patients with cardiac dysfunction and shock who applying milrinone, while there was no significant reduction in the incidence of myocardial infarction, all-cause mortality and no improvement of hemodynamics.
Indigofera oblongifolia Forssk. - An important underutilized multi-use leguminous shrub of Indian hot arid region
Authors: Singh Jai Prakash , Kannan Venkatesan , Patidar Anil , Kumar Mahesh , Swami Saurabh , Kumar Mahesh , Ranganathan Saranya , Patil Niteen Vasant 
Published: July 2022

Abstract
Species of Indigofera are important source of forage particularly in hot arid region and temperate areas. I . oblongifolia is one of the important underutilized leguminous browse shrub for small ruminants in hot arid region of India and traditionally utilize for its medicinal value. Its irregular patchy distribution was observed in depression of rocky areas, bunds of farmer fields and along the depression on the road sides in Jaisalmer and Pali district during collection. Soil samples collected from Pali district have high level of pH and electrical conductivity as compared to Jaisalmer which indicates its suitability to saline areas. It exhibited good plant growth in Jodhpur with respect to plant height (171.5 cm), number of branches (47.9) and canopy diameter (100-210 and 115-180 cm in north-south and east-west direction, respectively) after twelve months of planting in fields under protected condition. Phytochemical analysis revealed the richness of its leaves on total phenols, flavonoids and antioxidant capacity and its suitability as a browse species to ruminants in rangelands. The present study provides scientific information on distribution, browsing value, plant growth and traits variation, phytochemical, and its potential for forage and medicinal value for its sustainable utilization in rangelands of the Indian hot arid region.
APOE E4 is associated with cognitive decline but not with disease risk or age of onset in Nigerians with Parkinson’s disease
Authors: Okubadejo Njideka , Okunoye Olaitan , Ojo Oluwadamilola , Arabambi Babawale , Akinyemi Rufus , Osaigbovo Godwin , Abubakar Sani , Iwuozo Emmanuel , Wahab Kolawole , Agabi Osigwe , Agulanna Uchechi , Imarhiagbe Frank , Abiodun Oladunni , Achoru Charles , Adebowale Akintunde , Adeniji Olaleye , Akpekpe John , Alli Mohammed , Ani-Osheku Ifeyinwa , Arigbodi Ohwotemu , Balarabe Salisu , Bello Abiodun , Ekenze Oluchi , Erameh Cyril , Farombi Temitope , Fawale Michael , Komolafe Morenikeji , Nwani Paul , Nwazor Ernest , Nyandaiti Yakub , Obehighe Emmanuel , Obiabo Yahaya , Odeniyi Olanike , Odiase Francis , Ojini Francis , Onwuegbuzie Gerald , Osemwegie Nosakhare , Oshinaike Olajumoke , Otubogun Folajimi , Oyakhire Shyngle , Taiwo Funlola , Williams Uduak , Ozomma Simon , Zubair Yusuf , Curtis David , Hernandez Dena , Bandrés-Ciga Sara , Blauwendraat Cornelis , Singleton Andrew , Houlden Henry , Hardy John , Rizig Mie 
Published: July 2022

Abstract
The relationship between APOE polymorphisms and Parkinson’s disease (PD) in black Africans has not been previously investigated. We evaluated the association between APOE polymorphic variability and cognition in 1100 Nigerians with PD and 1097 matched healthy controls. Cognition in PD was assessed using the single item cognition question (item 1.1) of the MDS-UPDRS. APOE genotype and allele frequencies did not differ between PD and controls (p > 0.05). No allelic or genotypic association was observed between APOE and age at onset of PD. In PD, APOE ε4/ε4 conferred a two-fold risk of cognitive impairment compared to one or no ε4 (HR: 2.09 (95%CI: 1.13–3.89; p = 0.02)), while APOE ε2 was associated with modest protection against cognitive impairment (HR: 0.41 (95%CI 0.19–0.99, p = 0.02)). Altogether, our findings support previous studies in other ancestries, implying a role for APOE ε4 and ε2 as risk and protective factors respectively for cognitive decline in PD.
Amino acid PET-MRI of malignant gliomas for biopsy planning
Authors: Harat Maciej , Rakowska Józefina , Harat Marek , Szylberg Tadeusz , Furtak Jacek , Miechowicz Izabela , Małkowski Bogdan 
Published: July 2022

Abstract
Accurate determination of the border and grade of malignant gliomas is critical to patient management. Contrast-enhancing areas in MRI sequences of malignant gliomas are a target for biopsy, surgery, and radiation therapy, but there can be discrepancies between these areas and the actual extent of tumor. Here we prospectively collected over 400 serial biopsy specimens from 23 patients with contrast-enhancing high-grade gliomas using hybrid PET-MRI sequences to assess the utility of this imaging approach for obtaining accurate biopsies. In 35% cases, the biopsy result was changed to a higher tumor grade after the inclusion of FET-positive sites. In all cases, high FET uptake was visualized and confirmed outside areas of contrast enhancement on MRI, indicative of high-grade glioma. FET-PET can therefore be used to locate the most malignant areas of contrast-enhancing gliomas, thereby impacting consequent management.
Prescient Diagnostic Analysis for boron nutritional status in soy crops
Authors: Traspadini Edilaine Istéfani Franklin , Wadt Paulo Guilherme Salvador , Prado Renato de Mello , Roque Cassiano Garcia , Wassolowski Carlos Roberto 
Published: July 2022

Abstract
Boron is the most limiting micronutrient for soybean yield; therefore, accurate identification of its nutritional status is important for adequate fertilization management and maximize soybean yield potential. Currently, tools for nutritional status interpretation of B, such as the CND and DRIS are used; however, their efficacy is not considered to identify the true nutritional status of B. Here, we investigated the efficacy of these methods to identify the nutritional status of B in 140 commercial soybean crops to obtain nutritional standards for the DRIS and CND methods. In addition, an experiment of B dose calibration (0, 300, 600, 1200 and 1800 g ha-1) was installed to assess the quality of nutritional diagnoses using the PDA. We tested the limits of 0.25, 0.50, and 1.00 for the NRr and values of 1%, 5%, or 10% for YR. The DRIS method was more effective and, on average, its variations increased yield by 27% compared to CND, with the best performance of DRIS when NRr = 1.00 was adopted with 10% for YR. This study highlights the need for reliable and accurate diagnostic methods with global implications for crop sustainability by improving the efficacy of B fertilization programs and crop yield.
Singlet oxygen generation for selective oxidation of emerging pollutants in a flow-by electrochemical system based on natural air diffusion cathode
Authors: Li Yi , Xie Shiwei , Yao Jiaxiong 
Published: July 2022

Abstract
The decay of free radicals involved in side reactions is one of the challenges faced by electrochemical degradation of organic pollutants. To this end, a non-radical oxidation process was constructed by a natural air diffusion cathode (ADC) and a RuO2-Ti anode for cathodic hydrogen peroxide activation by anodic chlorine evolution. The ADC fabricated by the carbon black of BP2000 produced a stable concentration of hydrogen peroxide of 339.94 mg/L (current efficiency of 73.4%) without aeration, which was superior to the cathode made by the carbon black of XC72. The flow-by electrochemical system consisted of an ADC and a RuO2-Ti anode showed high selectivity to aniline compared to benzoate. Quenching experiments revealed the main active intermediate responsible for the pollutant degradation was singlet oxygen (1O2), which was also identified by the electron spin resonance (ESR) analysis. Finally, the steady-stable content of 1O2 was quantitatively determined to be 6.25×10− 11 M by the method of furfuryl alcohol (FFA) probe. Our findings provide a fast, low energy consumption and well controlled electrochemical oxidation method for selective degradation of organic pollutants.
Low delay flexible paper-based electrode for capacitive sensor filled through carbon-based materials
Authors: Liu Huan , Quan Jingran , Wang Junyao , Hou Qi , Wang Rui , Cui Bowen , Lang Tianhong , Chen Yansong , Pan Hongxu , Xu Jianxin , Yang Hanbo , Li Lixiang , Liu Yahao 
Published: July 2022

Abstract
Flexible electrodes are widely used in the manufacture of flexible sensors and wearable devices. However, with the development of science and technology and the large-scale utilization of metal resources, the question whether alternative materials can be found to ease the use of metal materials has been raised. Among them, paper-based electrodes have attracted special attention in the industry because of their degradability, low cost and high flexibility. Therefore, a low delay flexible paper-based electrode filled for capacitive sensors is proposed through carbon materials. Different from discussing the influence of single fiber, the paper-based electrode is manufactured by wet process. The effects of different fiber substrates on the physical properties and electrical signal properties of paper-based electrodes were discussed. The results show that the paper-based electrode has high conductivity, which is 18.52 S/cm. And there is a low delay in the process of electrical signal transmission. The phase frequency angle hardly changes at the signal frequency of 1 kHz, and the change of phase frequency angle is only 4.9 ° at the signal frequency of 300 kHz. The thickness of the guided electric paper is about 90 μm. Lower than common paper products. This study shows that the paper-based electrode has the advantages of high conductivity, low hysteresis, light and thin, which provides the possibility to be used as a flexible electrode.
Climate Obstruction and Facebook Advertising: How a Sample of Climate Obstruction Organizations Use social media to Disseminate Discourses of Delay
Authors: Mckie Ruth , Holder Faye , Mirza Sanober , Carbone Jake , Ngo-Lee Namson 
Published: July 2022

Abstract
In this article, we present the results of a content analysis of a sample of fossil fuel corporations, trade associations, and advocacy groups' ads using Facebook ad services during the election year from January 2020 to January 2021. Drawing on Habermas Theory of the Public Sphere, we argue that these climate obstruction organizations used big data to 1) disseminate discourses of delay and 2) target specific user categories on this platform. Using a re-developed typology by Miller and Lellis (2016) used by fossil fuel companies to describe the messages presented to stakeholders and the public, we found that different organizations used these messages to reinforce pre-existing beliefs on the importance of fossil fuels. In doing so, these organizations could use echo chambers to reassert their interests in the public voice and support standards of behavior that rely on fossil fuels to protect their industries. Moreover, these advertisements represent the evolving misinformation playbook from climate obstruction organizations that require further attention and consideration when assessing Facebook policies on misinformation, misleading claims and voluntarily responding to this misinformation without further regulation.
Effect of the mirror force on the collision rate due to energetic electron precipitation: Monte Carlo simulations
Authors: Katoh Yuto , Rosendahl Paul Simon , Ogawa Yasunobu , Hiraki Yasutaka , Tadokoro Hiroyasu 
Published: July 2022

Abstract
We study the effect of the mirror force on the collision rate due to the energetic electron precipitation into the ionosphere. We develop a simulation code for the motion of energetic electrons with the mirror force to solve the variation of the pitch angle of electrons during their precipitation. In this code, a module computing the collision between precipitating energetic electrons and neutral gas using the Monte Carlo method is employed. By combining the developed modules, altitude profiles of the collision rate due to energetic electron precipitation in the keV energy range are investigated, and the effect of the mirror force acting on precipitating electrons is examined. The simulation results show that the influence of the mirror force on the altitude profile of the collision rate is significant for electrons with a high initial pitch angle, corresponding to the pitch angle close to the loss cone. The effect of the mirror force results in the broadening of the altitude profile of the collision upward due to the reflection of mirroring electrons. Simulation results for energetic electrons with kinetic energies above 100 keV show that a secondary peak near the mirror point is formed in the altitude profile of the collision rate. The formation of the secondary peak can be explained by the stagnation of electrons around the mirror point. The relatively long duration staying in neutral gas results in the increase of the collision rate around the mirror point, against the smaller collision cross-section in the higher energy range. Simulation results reveal that the maximum collision rate in the altitude range lower than 100 km becomes one order of magnitude smaller if electrons in the kinetic energy range larger than tens of keV precipitate with the pitch angle close to the loss cone. The results of the present study emphasize the importance of the mirror force for the precise modeling of ionospheric response due to the energetic electron precipitation.
COVID-19 Vaccine Acceptance: Knowledge and beliefs
Authors: Alkattan Abdullah , Radwan Nashwa , Mahmoud Nagla , Alkhalifah Ahmed , Alshamlan Ammar , Alkamis Abdullah , Alfaifi Amal , Alanazi Wedad , Alfaleh Amjad , Haji Alhan , Alabdulkareem Khaled 
Published: July 2022

Abstract
Objectives: Vaccine acceptance varies across countries, generations, and the perceived personality of individuals. Investigating the knowledge, beliefs, and acceptability of COVID-19 vaccines among individuals is vital to ensuring adequate health system capacity and procedures and promoting the uptake of the vaccines.Methods: A cross-section study was conducted in 2021 to determine COVID-19 vaccine acceptance among Saudi residents using a new Vaccine Acceptability Questionnaire (VAQ). The VAQ contains 31 questions under three broad items: knowledge, beliefs, and underlying factors for COVID-19 vaccine acceptance.Results: The study included 281 residents to estimate their acceptance to receive COVID-19 vaccination. Around 70% of the included participants had a moderate to high COVID-19 vaccine acceptance rate during the data collection period. The risk increases to about two folds among undergraduates [OR=1.846 (1.034-3.296), p-value=0.036)] and increases to four folds among non-employed [OR=3.944 (2.310-6.737), p-value=0.001]. About 78% of participants with high and 44% with low COVID-19 vaccine acceptance (p-value=0.001) believed the vaccines were safe and effective. The belief that COVID-19 disease will be controlled within two years increased the risk for low vaccine acceptance by about two folds [OR=1.730 (1.035-2.891), p-value =0.035]. Good knowledge about COVID-19 vaccination significantly affected the acceptance rate (p-value =0.001). Conclusions: Several factors affect the intention of individuals to receive vaccines. Therefore, building good knowledge and health literacy through educational intervention programs, especially vaccine safety and effectiveness, is important for successful vaccination campaigns among the general population and ensuring control of the COVID-19 pandemic.
Research Trends and Hotspots on Connectomes from 2005 to 2021: A Bibliometric and Latent Dirichlet Allocation Application Study
Authors: Yan Yangye , Fan Guoxin , Liao Xiang , Zhao Xudong 
Published: July 2022

Abstract
Background
This study aimed to conduct a bibliometric analysis of publications on connectomes and illustrate its trends and hotspots using a machine-learning-based text mining algorithm.
Methods
Documents were retrieved from the Web of Science Core Collection (WoSCC) database and analyzed in Rstudio 1.3.1. Through quantitative and qualitative methods, the top 20 productive and impact academic journals and authors in the field of connectomes were compared in terms of the total number of publications and h_inde over time. Meanwhile, the countries/regions and institutions involved in connectome research were compared, as well as their scientific collaboration. The study analyzed topics and research trends by R package “bibliometrix”. The major topics of connectomes were classified by Latent Dirichlet allocation (LDA).
Results
The entire criteria were met by 6617 publications. Neuroimage outperformed all other relevant journals in terms of publication volume (680 articles) and impact factor (h index:98). The majority of articles were published by developed countries, with the United States having the most. The University of Pennsylvania and Beijing Normal University were the two most productive institutions. Neuroimaging analysis technology and brain functions and diseases were the two major topics of connectome research. The combination with machining learning or deep learning, as well as the focus on deep brain stimulation and hippocampus has been the recent trend in connectome research.
Conclusions
This study offers a comprehensive overview of connectome research and provides researchers with critical information for understanding the recent trends and hotspots of connectomes.
Prognosis of local invasive relapses after carcinoma in situ of the breast: A retrospective study from a population-based registry
Authors: MOHAMMED Samia KADA , Yonli Tienhan Sandrine Dabakuyo , Desmoulins Isabelle , Kamga Ariane Mamguem , Jankowski Clémentine , Padeano Marie-Martine , Loustalot Catherine , Costaz Hélène , Causeret Sylvain , Peignaux Karine , Rouffiac Magali , Coutant Charles , Arnould Laurent , Ladoire Sylvain 
Published: July 2022

Abstract
Purpose: The prognosis of local invasive recurrence (LIR) after prior carcinoma in situ (CIS) of the breast has not been widely studied and existing data are conflicting, especially considering the specific prognosis of this entity, compared to de novo invasive breast cancer (de novo IBC) and with LIR after primary IBC. Methods: We designed a retrospective study using data from the specialized Côte d’Or Breast and Gynecological cancer registry, between 1998 and 2015, to compare outcomes between 3 matched groups of patients with localized IBC: patients with LIR following CIS (CIS-LIR), patients with de novo IBC (de novo IBC) and patients with LIR following a first IBC (IBC-LIR). Distant relapse free (D-RFS), overall survival (OS), clinical and treatment features between the 3 groups were studied. Results: Among 8186 women initially diagnosed with IBC during our study period, we retrieved and matched 49 CIS-LIR to 49 IBC, and 46 IBC-LIR patients. At diagnosis, IBC/LIR in the 3 groups were mainly stage I, grade II, estrogen receptor-positive and HER2 negative. Metastatic diseases at diagnosis were higher in CIS-LIR group. A majority of patients received adjuvant systemic treatment, with no statistically significant differences between the 3 groups. There was no significant difference between the 3 groups in terms of OS or D-RFS. Conclusion: LIR after CIS does not appear to impact per se on survival of IBC, at least when appropriate adjuvant systemic treatments are prescribed.