bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical outcomes of image‐guided percutaneous drainage of pericardial effusion in cancer patients: A single‐center retrospective analysis
Authors: Hasegawa Tetsuya , Arai Yasuaki , Sone Miyuki , Sugawara Shunsuke , Itou Chihiro , Wada Shinji , Umakoshi Noriyuki , Kubo Takatoshi , Kimura Shintaro , Kusumoto Masahiko 
Published: July 2022

AbstractAimCatheter removal, survival, and recurrence rates after percutaneous pericardial effusion drainage in cancer patients are not fully understood. We evaluated the clinical outcomes of image‐guided percutaneous pericardial effusion drainage in cancer patients.MethodsFrom January 2014 to September 2017, 113 percutaneous drainages for symptomatic pericardial effusion were performed in 100 cancer patients (median 60 years; range, 7–84 years) using ultrasound or angio‐computed tomography. An 8‐Fr drainage catheter was placed using the Seldinger technique via the subxiphoid (n = 73), apical (n = 23), or left parasternal (n = 17) routes. Success rates, complications, and postprocedural clinical outcomes of drainages were retrospectively assessed.ResultsThe technical and clinical success rates were 100% and 99%, respectively, without major complications. The median duration of catheterization and evacuated pericardial effusion volume were 6 days (range, 1–72 days) and 970 ml (range, 140–7635 ml), respectively. Catheters were removed after the first drainage in 86 cases (86%). Symptomatic pericardial effusion recurred in nine patients after catheter removal, in whom redrainages were performed 13 times with a median duration to redrainage time of 48 days (range, 13–529 days). During the follow‐up period (median 106 days [range, 1–1396 days]), 61 patients died. The median survival was 140 days (95% confidence interval [CI], 95–276 days), and the median catheter‐free survival was 111 days (95% CI, 60–152 days).ConclusionsImage‐guided percutaneous pericardial effusion drainage for cancer patients is safe and helps alleviate symptoms. Additionally, catheter removal is possible in most patients, allowing a catheter‐free period for patients.
Failure to initiate trauma team activation for patients who meet the criteria in a level 1 paediatric trauma centre: which patients are missing out?
Authors: Sung Jonghoo , Yao Angela , Antoniou Georgia , Cooksey Rebecca , Winters Jacqueline , Ee Michael , Williams Nicole 
Published: July 2022

AbstractBackgroundTrauma team activation (TTA) is paramount in the early hospital management of trauma patients. This study aimed to evaluate factors which contribute to failure to activate the Trauma team for management of paediatric trauma.MethodsA retrospective cohort study of Emergency Department (ED) presentations at the paediatric major trauma hospital in Adelaide, South Australia was conducted over a 16‐month period. Data from the hospital's trauma registry, individual case files and digital medical records were evaluated to determine factors that were associated with no TTA.ResultsDuring the study period, 617 trauma patients who met Level 1 or Level 2 TTA criteria attended the trauma centre. For 29 (4.7%) of these patients, there was no TTA. Predictors of no TTA included sustaining abdomen and/or pelvis injuries compared to limb injuries (unadjusted odds ratio [OR] = 10.59, 95% confidence interval [CI] 1.98–56.69, P = 0.006), sustaining non‐accidental injury (NAI) versus an injury with vehicle involvement (OR = 30.13, 95% CI 6.43–141.21, P < 0.001), and arriving via emergency medical retrieval service compared to private vehicle (OR = 14.23, 95% CI 3.94–51.36, P < 0.001). No patients transferred directly to Paediatric Intensive Care Unit (PICU), or High Dependency Unit (HDU) received an appropriate TTA.ConclusionMultiple factors were associated with no TTA in paediatric trauma patients. The results highlight that even in PICU and HDU admissions and transfer patients, vigilant clarification of mechanism of injury and potential for occult injuries should be undertaken to ensure appropriate TTA and improve patient outcome.
Perceptions of pharmacogenetic exceptionalism and the implications for clinical management within an electronic health record
Authors: Butler Tiana , Brown Jacob , Jacobson Pamala A. , Stenehjem David 
Published: July 2022

AbstractGenetic exceptionalism refers to a concept that genetic information is distinct from other health data and therefore should have additional safety guards in place. The objective of this study was to establish perceptions of pharmacogenetic (PGx) exceptionalism and genetic information privacy and management within the electronic health record (EHR) from individuals who attended a PGx‐focused conference. A 47‐question survey was distributed to 370 attendees at a PGx conference in September 2020. The survey assessed demographics, professional characteristics, perceptions of PGx exceptionalism, knowledge of genetic laws and regulations, and EHR management of PGx information. Of the 370 participants invited to take the survey, 30% (n = 110) responded. Most respondents were pharmacists with postgraduate training (76.2%, n = 48). When asked whether PGx information was exceptional, 44% of respondents agreed while 32% disagreed. Agreement with PGx exceptionalism was associated most with respondents' lack of familiarity or knowledge with PGx. Over two‐thirds (67%) felt that all members of the healthcare team should be able to access their patients’ PGx information without restriction in the EHR. This study identified a lack of unanimity in the perception of PGx exceptionalism and the management of PGx information within the EHR across attendees of a PGx conference. Describing the perception of accessibility of PGx information within the EHR is important to ascertain for designing privacy‐related technology, institutional management policies, and legal regulations as this area in genetics is increasingly being implemented into clinical care and clinical standards of care need to be established.
Identification of individual subjects based on neuroanatomical measures obtained 7 years earlier
Authors: Jäncke Lutz , Valizadeh Seyed A. 
Published: July 2022

AbstractWe analysed a dataset comprising 118 subjects who were scanned three times (at baseline, 1‐year follow‐up, and 7‐year follow‐up) using structural magnetic resonance imaging (MRI) over the course of 7 years. We aimed to examine whether it is possible to identify individual subjects based on a restricted number of neuroanatomical features measured 7 years previously. We used FreeSurfer to compute 15 standard brain measures (total intracranial volume [ICV], total cortical thickness [CT], total cortical surface area [CA], cortical grey matter [CoGM], cerebral white matter [CeWM], cerebellar cortex [CBGM], cerebellar white matter [CBWM], subcortical volumes [thalamus, putamen, pallidum, caudatus, hippocampus, amygdala and accumbens] and brain stem volume). We used linear discriminant analysis (LDA), random forest machine learning (RF) and a newly developed rule‐based identification approach (RBIA) for the identification process. Using RBIA, different sets of neuroanatomical features (ranging from 2 to 14) obtained at baseline were combined by if–then rules and compared to the same set of neuroanatomical features derived from the 7‐year follow‐up measurement. We achieved excellent identification results with LDA, while the identification results for RF were very good but not perfect. The RBIA produced the best results, achieving perfect participant identification for some four‐feature sets. The identification results improved substantially when using larger feature sets, with 14 neuroanatomical features providing perfect identification. Thus, this study shows again that the human brain is highly individual in terms of neuroanatomical features. These results are discussed in the context of the current literature on brain plasticity and the scientific attempts to develop brain‐fingerprinting techniques.
Interictal discharges delay target‐directed eye movements and impair attentional set‐shifting in children with epilepsy
Authors: Warsi Nebras M. , Wong Simeon M. , Suresh Hrishikesh , Arski Olivia N. , Yan Han , Ebden Mark , Kerr Elizabeth , Smith Mary Lou , Ochi Ayako , Otsubo Hiroshi , Sharma Roy , Jain Puneet , Donner Elizabeth J. , Snead O. Carter , Ibrahim George M. 
Published: July 2022

AbstractObjectiveThe theory of transient cognitive impairment in epilepsy posits that lapses in attention result from ephemeral disruption of attentional circuitry by interictal events. Eye movements are intimately associated with human attention and can be monitored in real time using eye‐tracking technologies. Here, we sought to characterize the associations between interictal epileptiform discharges (IEDs), gaze, and attentional behavior in children with epilepsy.MethodsEleven consecutive children undergoing invasive monitoring with stereotactic electrodes for localization‐related epilepsy performed an attentional set‐shifting task while tandem intracranial electroencephalographic signals and eye‐tracking data were recorded. Using an established algorithm, IEDs were detected across all intracranial electrodes on a trial‐by‐trial basis. Hierarchical mixed‐effects modeling was performed to delineate associations between trial reaction time (RT), eye movements, and IEDs.ResultsHierarchical mixed‐effects modeling revealed that both the presence of an IED (β ± SE = 72.74 ± 24.21 ms, p = .003) and the frequency of epileptiform events (β ± SE = 67.54 ± 17.30 ms, p < .001) were associated with prolonged RT on the attentional set‐shifting task. IED occurrence at the time of stimulus presentation was associated with delays in gaze initiation toward the visual targets (p = .017).SignificanceThe occurrence of epileptiform activity in close temporal association with stimulus presentation is associated with delays in target‐directed gaze and prolonged response time, hallmarks of momentary lapses in attention. These findings provide novel insights into the mechanisms of transient impairments in children and support the use of visual tracking as a correlate of higher order attentional behavior.
IL‐38 orchestrates proliferation and differentiation in human keratinocytes
Authors: Mermoud Loïc , Shutova Maria , Diaz‐Barreiro Alejandro , Talabot‐Ayer Dominique , Drukala Justyna , Wolnicki Michal , Kaya Gürkan , Boehncke Wolf‐Henning , Palmer Gaby , Borowczyk Julia 
Published: July 2022

AbstractInterleukin (IL)‐38 is a member of the IL‐1 cytokine family with reported anti‐inflammatory activity. The highest constitutive IL‐38 expression is detected in the skin, where it is mainly produced by differentiating keratinocytes. However, little data are available regarding its biological functions. In this study, we investigated the role of IL‐38 in skin physiology. We demonstrate here that dermal fibroblasts and epithelial cells of skin appendages, such as eccrine sweat glands and sebaceous glands, also express IL‐38. Next, using two‐ and three‐dimensional cell cultures, we show that endogenous expression of IL‐38 correlates with keratinocyte differentiation and its ectopic overexpression inhibits keratinocyte proliferation and enhances differentiation. Accordingly, immunohistochemical analysis revealed downregulation of IL‐38 in skin pathologies characterized by keratinocyte hyperproliferation, such as psoriasis and basal or squamous cell carcinoma. Finally, intracellular IL‐38 can shuttle between the nucleus and the cytoplasm and its overexpression modulates the activity of the transcription regulators YAP and ID1. Our results indicate that IL‐38 can act independently from immune system activation and suggest that it may affect the epidermis directly by decreasing proliferation and promoting differentiation of keratinocytes. These data suggest an important role of keratinocyte‐derived IL‐38 in skin homeostasis and pathologies characterized by epidermal alterations.
Bioimpedance phase angle and sarcopenia in older patients with prostate cancer
Authors: Park Hae‐Yeon , Park Yong Hyun , Lee Ji Youl , Lee Jong In 
Published: July 2022

AimThe purpose of this study was to evaluate the factors associated with the bioimpedance phase angle (PhA) in older patients with prostate cancer, and to determine the optimal cutoff for the PhA in patients with sarcopenia and prostate cancer.MethodsThis retrospective cross‐sectional analysis enrolled patients with prostate cancer aged ≥60 years. Appendicular skeletal muscle mass and PhA estimated by bioimpedance analysis, grip strength, the five‐time chair stand test, gait speed, the Short Physical Performance Battery, the 2‐min walk test and the International Physical Activity Questionnaire Short Form were obtained at enrollment. The diagnosis of sarcopenia was based on the 2019 consensus of the Asian Working Group for Sarcopenia.ResultsIn total, 119 male participants (mean age = 70.7 ± 6.1 years) were available for analysis. A multivariable linear regression model revealed that age, body mass index and the maximal grip strength value were associated with the PhA. The area under the receiver operating characteristic curve value of the PhA for sarcopenia diagnosis was 0.77 (95% confidence interval 0.64–0.90, P < 0.001), with a PhA cutoff value of 4.87°.ConclusionsPhA estimated by bioimpedance analysis may be utilized as useful clinical biomarker for reflecting muscle strength and sarcopenia in older patients with prostate cancer. Geriatr Gerontol Int 2022; 22: 623–627.
Predictors of iron versus erythropoietin responsiveness in anemic hemodialysis patients
Authors: Hildebrand Sarah , Busbridge Mark , Duncan Neill D. , Tam Frederick W. K. , Ashby Damien R. 
Published: July 2022

AbstractAnemia protocols for hemodialysis patients usually titrate erythropoietin (ESA) according to hemoglobin and iron according to a threshold of ferritin, with variable response seen. A universally optimum threshold for ferritin may be incorrect, and another view is that ESA and iron are alternative anemia treatments, which should be selected based on the likely response to each. Hemodialysis patients developing moderate anemia were randomised to treatment with either an increase in ESA or a course of intravenous iron. Over 2423 patient‐months in 197 patients, there were 133 anemia episodes with randomized treatment. Treatment failure was seen in 20/66 patients treated with ESA and 20/67 patients treated with iron (30.3 vs. 29.9%, p = 1.0). Successful ESA treatment was associated with lower C‐reactive protein (13.5 vs. 28.6 mg/L, p = 0.038) and lower previous ESA dose (6621 vs. 9273 μg/week, p = 0.097). Successful iron treatment was associated with lower reticulocyte hemoglobin (33.8 vs. 35.5 pg, p = 0.047), lower hepcidin (91.4 vs. 131.0 μg/ml, p = 0.021), and higher C‐reactive protein (29.5 vs. 12.6 mg/L, p = 0.085). A four‐variable iron preference score was developed to indicate the more favorable treatment, which in a retrospective analysis reduced treatment failure to 17%. Increased ESA and iron are equally effective, though treatment failure occurs in almost 30%. Baseline variables including hepcidin can predict treatment response, and a four‐variable score shows promise in allowing directed treatment with improved response rates.
Off‐flavour compounds in collagen peptides from fish: Formation, detection and removal
Authors: Wang Xilong , Le Bei , Zhang Na , Bak Kathrine H. , Zhang Yuhao , Fu Yu 
Published: July 2022

SummaryCollagen peptides from fish exhibit excellent bioactive and functional properties, which have great potential as functional ingredients in the food industry. However, the off‐flavour in collagen peptides from fish limits their comprehensive application in the food industry. Therefore, removing the off‐flavour from collagen peptides is of great importance. In this regard, this review firstly recaps the formation mechanism of main off‐flavour compounds of collagen peptides from fish. Furthermore, the main detection methods for off‐flavour compounds are described. More importantly, the removal methods of off‐flavour compounds in collagen peptides derived from fish, such as physical, chemical, biotechnological and combination methods, are emphatically reviewed. In addition, the current challenges and future perspectives are discussed. The present work provides a theoretical reference for removal of collagen peptides from fish.
The formation of egg white polypeptide‐selenium complex particles: mechanism, stability and functional properties
Authors: Tan Jin‐Chao , Tang Hong‐Yan , Xu Qing‐Ling , Zheng Ying‐Min , Su Dong‐Xiao , He Shan , Zeng Qing‐Zhu , Yuan Yang 
Published: July 2022

SummarySelenium (Se) is an essential trace element in human health. In this article, egg white polypeptide (EWP) was used as the reducing agent and stabiliser to prepare a novel type of EWP‐selenium complex nanoparticles (EWP‐SeNPs). Particle size, morphology, FT‐IR, stability, and functional properties of EWP‐SeNPs were characterised. The results showed that EWP‐SeNPs were 30–50 nm in diameter and were spherical. The SeNPs complexed with the EWP through O‐ and N‐ containing groups. This reaction was entropy‐driven spontaneous and the binding force was mainly hydrophobic. The stability of EWP‐SeNPs was best at pH = 10. Moreover, EWP‐SeNPs showed significantly inhibitory effect on HepG‐2 cells in the range of 6.2500 to 50.0000 μg mL−1. Anti‐bacterial effect occurred when the concentration of EWP‐SeNPs was 1.2500 mg mL−1. This study would provide a green method for synthesising stable SeNPs, which was helpful for further evaluation in the food field.
FcγRIIb protects from reperfusion injury by controlling antibody and type I IFN‐mediated tissue injury and death
Authors: de Brito Camila Bernardo , Ascenção Fernando Roque , Arifa Raquel Duque Nascimento , Lima Renata Lacerda , Garcia Zélia Menezes , Fagundes Micheli , Resende Brenda Gonçalves , Bezerra Rafael Oliveira , Queiroz‐Junior Celso Martins , Santos Anna Clara Paiva Menezes dos , Oliveira Milton Adriano Pelli , Teixeira Mauro Martins , Fagundes Caio Tavares , Souza Daniele Glória 
Published: July 2022

AbstractIntestinal ischemia and reperfusion (I/R) is accompanied by an exacerbated inflammatory response characterized by deposition of IgG, release of inflammatory mediators, and intense neutrophil influx in the small intestine, resulting in severe tissue injury and death. We hypothesized that FcγRIIb activation by deposited IgG could inhibit tissue damage during I/R. Our results showed that I/R induction led to the deposition of IgG in intestinal tissue during the reperfusion phase. Death upon I/R occurred earlier and was more frequent in FcγRIIb−/− than WT mice. The higher lethality rate was associated with greater tissue injury and bacterial translocation to other organs. FcγRIIb−/− mice presented changes in the amount and repertoire of circulating IgG, leading to increased IgG deposition in intestinal tissue upon reperfusion in these mice. Depletion of intestinal microbiota prevented antibody deposition and tissue damage in FcγRIIb−/− mice submitted to I/R. We also observed increased production of ROS on neutrophils harvested from the intestines of FcγRIIb−/− mice submitted to I/R. In contrast, FcγRIII−/− mice presented reduced tissue damage and neutrophil influx after reperfusion injury, a phenotype reversed by FcγRIIb blockade. In addition, we observed reduced IFN‐β expression in the intestines of FcγRIII−/− mice after I/R, a phenotype that was also reverted by blocking FcγRIIb. IFNAR−/− mice submitted to I/R presented reduced lethality and TNF release. Altogether our results demonstrate that antibody deposition triggers FcγRIIb to control IFN‐β and IFNAR activation and subsequent TNF release, tailoring tissue damage, and death induced by reperfusion injury.
Societal practices as predictors of sustainable outcomes: Evidence across 57 countries
Authors: Das Roshni 
Published: July 2022

AbstractThe purpose of this paper is to present evidence that cultural factors account for sustainability‐based outcomes at the national level. Instead of subjective and perception‐based measure of sustainable propensity of individuals as used in previous research, this paper uses the directly and objectively captured sustainability scores from the Environmental Performance Index report. The test sample is comprised of 57 countries. Bayesian regression modelling is adopted. One important theoretical contribution is that sustainable competitiveness may be conceptualised as a higher‐order concept consisting of two first‐order constructs, namely primary resources and derivative capabilities. Cultural determinants vary substantially in the way they are related to these two components. Four cultural characteristics are related to derivative capabilities, while none have any predictive relationship with respect to primary resources. Researchers may use the findings of this study to similarly model the normative or soft factors embedded in hard environmental performance metrics, in the future. Country clusters may exhibit variations and nuances which warrant further investigation.
Health economic assessment of negative pressure wound therapy use in the management of subcutaneous abdominal wound healing impairment (SAWHI) in the out‐of‐hospital setting
Authors: Brennfleck Frank W. , Bongards Christine 
Published: July 2022

AbstractDevelopment of subcutaneous abdominal wound healing impairment (SAWHI) can greatly affect patient care. Complications from SAWHI include delayed healing, increased risk of infection, and fascial dehiscence resulting in increased patient care and associated costs. Treatment options include conventional wound treatment or negative pressure wound therapy, both of which can be used in the out‐of‐hospital setting. However, limited published evidence on cost‐effectiveness exists. A conservative health economic model was created to assess the cost–benefit of negative pressure wound therapy in the out‐of‐hospital setting for the management of SAWHI. Study data from a published multicentre randomised controlled trial were used and represented 221 patients that received care in the out‐of‐hospital setting. The mean per‐patient total cost within 42 days was slightly higher in the negative pressure wound therapy group (2034.98 € versus 1918.91 €); however, when wound closure rates were considered, a cost savings of 4155.98 € per closed wound was observed with the use of negative pressure wound therapy (4324.34 € versus 8480.32 €). A cost‐effectiveness analysis was constructed, and negative pressure wound therapy was observed to have a lower cost of care and a higher incremental closure rate.