bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PENAMBAHAN DAGING KERANG KALANDUE (Polymesoda erosa) TERHADAP NILAI ORGANOLEPTIK DAN PROKSIMAT BAKSO KALANDUE
Authors: Iqbal Muhammad , Haslianti Haslianti , Suwarjoyowirayatno Suwarjoyowirayatno 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh penambahan daging kerang kalandue yang berbeda terhadap nilai organoleptik dan nilai proksimat bakso kerang kalandue. Rancangan penelitian yang digunakan adalah uji hipotesis paired sample t-test dengan 2 perlakuan dan 3 kali ulangan sehingga di peroleh 6 unit percobaan. Perlakuan yang diberikan adalah penambahan daging kalandue kalandue 15% daging kalandue (P1), 20% daging kalandue (P2) dan 35% daging kalandue (P3) dan 40% daging kalandue (P4). Parameter yang diamati adalah nilai organoleptik (kenampakan, bau, rasa dan tekstur) dan nilai proksimat (air, abu, protein dan lemak). Penambahan daging kerang kalandue pada produk bakso daging kerang kalandue pada nilai organoleptik kenampakan, bau dan rasa tidak berbeda secara signifikan maka H0 ditolak sedangkan nilai organoleptik tekstur berbeda secara signifikan maka H0 diterima. Penambahan daging kerang kalandue pada produk bakso daging kerang kalandue mempengaruhi pada nilai proksimat pada setiap perlakuan. Penambahan daging kerang kalandue pada produk bakso daging kerang kalandue mempengaruhi pada nilai proksimat pada setiap perlakuan. Nilai kadar air sekitar 63,30% (P1), 61,49% (P2), 66,91% (P3) dan 68,68% (P4) , nilai kadar abu 0,97% (P1), 1,67% (P2), 1,63% (P3) dan 1,80% (P4), nilai kadar protein 15,98% (P1), 7,38% (P2), 11,80% (P3) dan 7,89% (P4), dan nilai kadar lemak 1,85% (P1), 1,72% (P2), 1,74 (P3) dan 1,67% (P4).
Analisis Kemampuan Literasi Matematika Ditinjau Dari Keyakinan Matematika Siswa SMP Di Wilayah Pesisir Kabupaten Konawe
Authors: Zuliyati Wa Ode , Sudia Muhammad , Kadir Kadir 
Published: November 2022

Penelitian ini bertujuan untuk menganalisis kemampuan literasi matematika ditinjau dari keyakinan matematika dari setiap kategori keyakinan matematika dan untuk mengetahui hubungan antara kemampuan literasi dan keyakinan matematika siswa. Penelitian ini merupakan penelitian deskriptif kuantitatif yang dilaksanakan pada siswa SMP Negeri di wilayah pesisir Kabupaten Konawe. Sampel penelitian diperoleh dengan metode purposive sampling (sampel total) dimana seluruh siswa kelas VIII yang berjumlah 78 siswa diambil sebagai sampel. Data diolah dengan menggunakan Microsoft Excel serta SPSS dan hasilnya menunjukkan bahwa kemampuan literasi matematika siswa tergolong kategori rendah sebanyak 63 orang atau 80,77%, kategori sedang sebanyak 13 orang atau 16,67%, dan tinggi sebanyak 2 orang atau 2,56%. Keyakinan matematika siswa tergolong kategori sedang (50 orang) atau 64,10%, kategori rendah (6 orang) atau 7,69% dan kategori tinggi (22 orang) atau 28,21%. Siswa dengan keyakinan matematika tinggi memiliki kemampuan literasi yang sedang, siswa dengan keyakinan matematika sedang memiliki kemampuan literasi rendah dan siswa dengan keyakinan matematika rendah memiliki kemampuan literasi yang rendah.
Meningkatkan Hasil Belajar Siswa Kelas IX.3 SMP Negeri 9 Kendari pada Materi Bentuk Pangkat dan Akar Melalui Penerapan Model Pembelajaran Koopertif Tipe STAD
Authors: Suhaena Suhaena 
Published: November 2022

Banyak siswa mengalami kesulitan dalam memahami konsep matematika, sehingga tidak jarang pelajaran matematika sering menjadi momok bagi siswa.Oleh karena itu, guru perlu selalu mencari alternatif model pembelajaran sehingga pelajaran ini menjadi menarik bagi siswa dan kesulitan siswa dapat dikurangi serta siswa senang terlibat didalamnya.Kegiatan pembelajaran dengan menempatkan siswa sebagai pusat kegiatan belajar merupakan salah satu pilihan yang baik untuk diterapkan. Dengan demikian siswa akan terlibat secara aktif dalam pembelajaran sehingga kegiatan belajar yang dilakukan akan lebih berkesan yang pada akhirnya bermuara pada peningkatan hasil belajar.Salah satu model pembelajaran yang sesuai dengan maksud tersebut adalah model pembelajaran kooperatif tipe STAD (Student Teams Achievement Devisions). Kegiatan pembelajaran pada model ini berpusat pada kegiatan belajar kelompok, dimana antara tiap-tiap anggota kelompok terjalin hubungan yang saling mendukung dan saling membantu untuk mendapatkan prestasi kelompok yang baik.Hasil penelitian dalam dua siklus pembelajaran menunjukkan bahwa hasil belajar yang dicapai oleh siswa dengan diterapkannya model pembelajaran kooperatif tipe STAD (Student Teams Achievement Devisions) pada materi pelajaran Bentuk Pangkat dan Akar menunjukkan peningkatan yang cukup baik, dimana pada akhir siklus II diperoleh nilai rata-rata 72,16 dengan jumlah siswa yang mencapai nilai ≥ 65,00 sebanyak 25 orang (80,65%). Hasil ini jauh lebih baik bil dibandingkan dengan hasil tes awal dengan rata-rata 47,74 dan hasil tes siklus I dengan rata-rata 52,42. Hasil lain yang dicapai adalah terjadinya penurunan tingkat kesulitan siswa memahami konsep matematika pokok bahasan Bentuk Pangkat dan Akar. Kesimpulan yang dapat diambil adalah dengan menggunakan diterapkannya model pembelajaran kooperatif tipe STAD (Student Teams Achievement Devisions), dapat dikurangi kesulitan siswa kelas IX.3 SMP Negeri 9 Kendari dalam memahami konsep matematika khususnya pada pokok bahasan Bentuk Pangkat dan Akar, serta hasil belajar siswa dapat ditingkatkan dengan baik.
A combination containing natural extracts of clove, Sophora flower bud, and yam improves fertility in aged female mice via multiple mechanisms
Authors: Liu Wei , Wang Xinyu , Chen Yating , Zhang Huiyu , Chen Jing , Zhang Jing , Wu Tinghe , Li Jing 
Published: November 2022

IntroductionWith society development, the age at which women choose to have children has been gradually delayed. To improve the reduced fertility in women at advanced maternal age, we developed a combination containing natural extracts from clove, Sophora flower bud and Chinese yam with a mass ratio 15:6:10 and named it as DACHAO.Methods and ResultsWe then gavage DACHAO at a dose of 310 mg/kg BW to female mice at 10 month of age and investigated its effects on ovarian functions. Using MitoTracker probes, ROS, and JC-1 staining, we found that DACHAO treatment improved mitochondria functions in oocytes from aged mice. We also observed increased blastocyst formation when mature oocytes from control and DACHAO treated mice were for IVF and in vitro embryo culture. Cell counting and TUNEL assay further revealed increased cell numbers and decreased apoptosis in blastocysts of DACHAO group. After control or DACHAO treated mice being mated with fertile male mice, fertility test revealed a greater first litter size in the DACHAO group. Further studies demonstrated that DACHAO treatment could alleviate the retarded ovarian function in aged mice via changes in serum hormone levels, over-expression of antioxidant factors, under-expression of inflammation-related factors, and reduced apoptosis in the ovaries.DiscussionThus, the new combination DACHAO will be a good choice in clinic to improve ovarian functions for women at advanced maternal age.
Establishing a glutamine metabolism-based model for predicting the prognosis of low-grade glioma
Authors: Zhang Mingshi , Li Mingjun , Liu Jinrui , Gu Zhicheng , Lu Yanmei , Long Yu , Hou Yuyi 
Published: November 2022

Background: The natural history of patients with low-grade glioma (LGG) varies widely, but most patients eventually deteriorate, leading to poor prognostic outcomes. We aim to develop biological models that can accurately predict the outcome of LGG prognosis.Methods: Prognostic genes for glutamine metabolism were searched by univariate Cox regression, and molecular typing was constructed. Functional enrichment analysis was done to evaluate potential prognostic-related pathways by analyzing differential genes in different subtypes. Enrichment scores of specific gene sets in different subtypes were measured by gene set enrichment analysis. Different immune infiltration levels among subtypes were calculated using algorithms such as CIBERSORT and ESTIMATE. Gene expression levels of prognostic-related gene signatures of glutamine metabolism phenotypes were used to construct a RiskScore model. Receiver operating characteristic curve, decision curve and calibration curve analyses were used to evaluate the reliability and validity of the risk model. The decision tree model was used to determine the best predictor variable ultimately.Results: We found that C1 had the worst prognosis and the highest level of immune infiltration, among which the highest macrophage infiltration can be found in the M2 stage. Moreover, most of the pathways associated with tumor development, such as MYC_TARGETS_V1 and EPITHELIAL_MESENCHYMAL_TRANSITION, were significantly enriched in C1. The wild-type IDH and MGMT hypermethylation were the most abundant in C1. A five-gene risk model related to glutamine metabolism phenotype was established with good performance in both training and validation datasets. The final decision tree demonstrated the RiskScore model as the most significant predictor of prognostic outcomes in individuals with LGG.Conclusion: The RiskScore model related to glutamine metabolism can be an exceedingly accurate predictor for LGG patients, providing valuable suggestions for personalized treatment.
Phosphoproteomic mapping of CCR5 and ACKR2 signaling properties
Authors: Vacchini Alessandro , Maffioli Elisa , Di Silvestre Dario , Cancellieri Cinzia , Milanesi Samantha , Nonnis Simona , Badanai Sabrina , Mauri Pierluigi , Negri Armando , Locati Massimo , Tedeschi Gabriella , Borroni Elena Monica 
Published: November 2022

ACKR2 is an atypical chemokine receptor which is structurally uncoupled from G proteins and is unable to activate signaling pathways used by conventional chemokine receptors to promote cell migration. Nonetheless, ACKR2 regulates inflammatory and immune responses by shaping chemokine gradients in tissues via scavenging inflammatory chemokines. To investigate the signaling pathways downstream to ACKR2, a quantitative SILAC-based phosphoproteomic analysis coupled with a systems biology approach with network analysis, was carried out on a HEK293 cell model expressing either ACKR2 or its conventional counterpart CCR5. The model was stimulated with the common agonist CCL3L1 for short (3 min) and long (30 min) durations. As expected, many of the identified proteins are known to participate in conventional signal transduction pathways and in the regulation of cytoskeleton dynamics. However, our analyses revealed unique phosphorylation and network signatures, suggesting roles for ACKR2 other than its scavenger activity. In conclusion, the mapping of phosphorylation events at a holistic level indicated that conventional and atypical chemokine receptors differ in signaling properties. This provides an unprecedented level of detail in chemokine receptor signaling and identifying potential targets for the regulation of ACKR2 and CCR5 function.
Dosimetric and biological comparisons of single planning and double plannings for bilateral lung cancer SBRT planning based on the Cyber-Knife system
Authors: Guo Xueling , Su Huanfan , Wan Fuying , Zhao XianZhi , Cao Tingting , Dai Zhitao , Zhang HuoJun 
Published: November 2022

ObjectiveThe aim is to investigate the influence of single planning (Plan S) and double plannings (Plan D) on bilateral lung cancer stereotactic body radiation therapy planning from the perspective of dosimetry and biology respectively. Methods Cases with bilateral lung cancer patients who had undergone SBRT with the Cyber-Knife were enrolled, and a single planning and double plannings were designed in the Multiplan@4.2 treatment planning system equipped with the Cyber-Knife system. The single plan was to optimize the two target volumes in a separate plan, while the dual plan is to optimize two target volumes respectively in two separate plans, then perform dose superposition. Then based on the dosimetric results, the biological parameters were calculated. Thus the quality of SBRT plans for those bilateral lung cancer designed by the two methods were compared and evaluated according to the dosimetric and biological results.ResultsThe dose distribution of both planning target volumes and surrounding organs at risk in Plan S and Plan D could meet the clinical prescription requirements. The target conformity index and the new conformity index of PTV were closer to 1 in the Double plannings, and the dose gradient GI in the Plan D was smaller than Plan S. For organs at risks, the doses received by the Plan D were relatively small. In terms of biological models, for the equivalent uniform dose of normal lung tissue, heart and esophagus, the Plan D was 6.51% (P=0.045), 19.8% (P=0.022), 27.08% (P&gt;0.05) lower than Plan S respectively. The results showed that the equivalent uniform dose of normal tissue in the Plan D was lower relative to Plan S.ConclusionsDosimetric and biological results show that both the use of Plan D have an advantage of protecting normal tissues, and it was suggested that to design double plannings for bilateral lung cancer stereotactic body radiation therapy planning based on Cyber-Knife in the clinical practice.
The role of preoperative inflammatory markers in patients with central nervous system tumors, focus on glioma
Authors: Chen Fan , Chao Min , Huang Tao , Guo Shaochun , Zhai Yulong , Wang Yuan , Wang Na , Xie Xuan , Wang Liang , Ji Peigang 
Published: November 2022

BackgroundCNS tumors, particularly gliomas, are associated with a high rate of disability and lethality, and are typically diagnosed with histopathology and immunohistochemistry. Our research aims to develop a minimally invasive method for diagnosing, grading and molecular typing glioma.MethodsWe collected patients who underwent surgery for glioma, Trigeminal neuralgia/Hemifacial spasm, schwannoma, pituitary adenomas and meningioma at our hospital from June 2019 to June 2021. Preoperative WBCs, neutrophils, lymphocytes, monocytes, platelet counts and albumin levels were collected. Preoperative NLR, dNLR, PLR, LMR and PNI were calculated, and the correlation between them and glioma diagnosis as well as grading was analyzed. We also evaluated the diagnostic significance of NLR, dNLR, PLR, LMR, PNI and their combinations for gliomas, particularly GBM, as well as the diagnostic significance of IDH molecular typing of gliomas.ResultsThere were 182 healthy samples and 3101 diseased samples in our study. Compared with other groups, glioma patients had significantly higher preoperative NLR, dNLR and PLR values, but lower LMR and PNI values. Further analysis showed that NLR, dNLR, and PLR were positively correlated with glioma grading, while LMR and PNI were negatively correlated with glioma grading. For the diagnosis of glioma, NLR showed a maximum AUC value of 0.8099 (0.7823-0.8374). For GBM, NLR showed a maximum AUC value of 0.9585 (0.9467-0.9703). In the combination, NLR+dNLR showed the highest AUC value of 0.8070(0.7849-0.8291). NLR showed significant statistical significance in all grades of glioma IDH molecular typing, while PLR did not show statistical significance.ConclusionsNLR has the greatest value for the diagnosis, differential diagnosis, grading and molecular typing of gliomas. The NLR+dNLR combination also showed high sensitivity and specificity. We believe that inflammatory parameters may serve as economical and specific markers for glioma diagnosis, grading, molecular typing, and progression.
The longitudinal course of pediatric acute respiratory distress syndrome and its time to resolution: A prospective observational study
Authors: Wong Judith Ju Ming , Tan Herng Lee , Sultana Rehena , Ma Yi-Jyun , Aguilan Apollo , Lee Siew Wah , Kumar Pavanish , Mok Yee Hui , Lee Jan Hau 
Published: November 2022

BackgroundThe longitudinal course of patients with pediatric acute respiratory distress syndrome (PARDS) is not well described. In this study, we describe the oxygenation index (OI) and oxygen saturation index (OSI) in mild, moderate, and severe PARDS over 28 days and provide pilot data for the time to resolution of PARDS (Tres), as a short-term respiratory-specific outcome, hypothesizing that it is associated with the severity of PARDS and clinical outcomes.MethodsThis prospective observational study recruited consecutive patients with PARDS. OI and OSI were trended daily over 28 days. Tres (defined as OI &lt; 4 or OSI &lt; 5.3 on 2 consecutive days) were described based on PARDS severity and analyzed with Poisson and logistic regression to determine its association with conventional outcomes [mechanical ventilation (MV) duration, intensive care unit (ICU) and hospital length of stay, 28-day ventilator-free days (VFD), and 28-day ICU-free days (IFD)].ResultsThere were 121 children included in this study, 33/121(27.3%), 44/121(36.4%), and 44/121(36.4%) in the mild, moderate, and severe groups of PARDS, respectively. OI and OSI clearly differentiated mild, moderate, and severe groups in the first 7days of PARDS; however, this differentiation was no longer present after 7days. Median Tres was 4 (interquartile range: 3, 6), 5 (4, 7), and 7.5 (7, 11.5) days; p &lt; 0.001 for the mild, moderate, and severe groups of PARDS, respectively. Tres was associated with increased MV duration, ICU and hospital length of stay, and decreased VFD and IFD.ConclusionThe oxygenation defect in PARDS took progressively longer to resolve across the mild, moderate, and severe groups. Tres is a potential short-term respiratory-specific outcome, which may be useful in addition to conventional clinical outcomes but needs further validation in external cohorts.
Identificación de parásitos y bacterias asociados a fuentes de agua en la zona rural del municipio de Circasia, Quindío
Authors: Lora-Suarez Fabiana María , Sierra-Rengifo Laura , Loango-Chamorro Nelsy 
Published: November 2022

Uno de los recursos indispensables del ser humano es el agua, pero son muy pocas las poblaciones que disponen de este elemento en la manera más adecuada. Para el Quindío se han realizado estudios sobre la calidad del agua potable de la zona urbana, pero no existen estudios realizados en la zona rural, por esta razón evaluamos las condiciones del agua consumida por los individuos de la población rural para ello se realizaron pruebas BD BBL Crystal para la identificación de bacterias y técnica de Ritchie e IFI para parásitos, Se encontraron en total 9 especies de bacterias, donde las más frecuentes fueron Enterobacter cloacae y Klebsiella oxytoca, 11 géneros de parásitos pertenecientes a helmintos y protozoos los más frecuentes fueron Opisthorchis sp ,Strongyloides sp y Giardia sp y 7 géneros de algas. A pesar de que los valores de los parámetros fisicoquímicos estuvieron dentro de los límites establecidos por la normatividad, estas condiciones están permitiendo el crecimiento de microorganismos en el agua, la mayoría son causantes de diversas enfermedades gastrointestinales en humanos, la presencia de estos organismos nos indica que el agua consumida por los habitantes del sector rural del municipio de Circasia no es apta para consumo humano ya que cuenta con la presencia de bacterias, helmintos y protozoos, y no cumple con las condiciones de calidad de agua potable y al no tener un tratamiento permanente debe ser obligatoriamente hervida antes de consumirse.
Accidente cerebro vascular (ACV) y perfil lipídico en un programa de riesgo cardiovascular de Armenia, Quindío
Authors: Nieto-Cárdenas Olga Alicia , Pulgarín-Cardona Airon Jhoan , Rairan-Penagos Mario Alejandro , Duque-Valencia Jorge Luis , Cárdenas-Medina Karem 
Published: November 2022

Objetivo: Describir el perfil lipídico en pacientes con accidente cerebro vascular en un programa de riesgo cardiovascular en una institución de salud de primer nivel de Armenia, Quindío durante el año 2018.
Métodos: Se realizó un estudio descriptivo de corte transversal, con una muestra de 300 personas en una población de una Institución Prestadora de Servicios de primer nivel de atención, con diagnóstico o antecedente de ACV. Se describieron variables en promedio, desviación estándar e intervalos de confianza, se hizo un análisis comparativo por sexo. Se realizaron análisis de varianza y Chi cuadrado. Se estableció una relación de las variables del perfil lipídico con el diagnóstico y antecedente de ACV. Se consideró un valor de p<0,05 para diferencias estadísticamente significativas.
Resultados: Se encontró una prevalencia de ACV en la población del primer nivel de atención de 2,7%, y una relación estadísticamente significativa entre el valor bajo de las HDL, con el antecedente de ACV (valor de p=0,024) y del diagnóstico de ACV con TG elevados (valor de p=0,041).
Conclusiones: La literatura describe las LDL como factor altamente relacionado con el desarrollo de ACV, sin embargo, el presente estudio encontró que existe una relación estadísticamente significativa entre el diagnóstico de ACV con TG elevados y de los antecedentes de ACV con bajos niveles de HDL; estas 2 condiciones se han encontrado como prevalentes en esta población de RCV.
Estimación de dinámicas poblacionales de las especies canina y felina en los municipios del Quindío
Authors: Hurtado-Tobón Luís Hernando , García-González María Dolly , Galvis-Soto Diana Milena , Méndez-Parra Rosa María 
Published: November 2022

En este documento se resumen resultados y detalles del estudio sobre la estimación de las poblaciones de caninos y felinos, con algunas de sus características, en cada uno de los municipios del Quindío.
El levantamiento de información sobre las poblaciones, más el análisis de características de convivencia con la población humana, responde a una necesidad de la Secretaría de Salud del Departamento del Quindío de incluir esta temática en su Plan de Desarrollo 2020-2023, respondiendo al objetivo de “Promover la disminución de la exposición a condiciones y factores de riesgo ambientales, sanitarios y biológicos, para mitigar las contingencias y daños producidos por enfermedades transmisibles (zoonosis y vectores)”.
Orientación vocacional a los estudiantes de grado 11 en el Departamento del Quindío: una contribución a la disminución de la deserción en la población universitaria
Authors: Hurtado-Tobón Luís Hernando , García-González María Dolly , Méndez-Parra Rosa María 
Published: November 2022

La aplicación de la prueba de orientación vocacional y profesional Búsqueda Autodirigida o prueba SDS (Search Directed Self), a los futuros bachilleres de colegios públicos del departamento del Quindío, es una actividad presencial dentro del Programa de Apoyo a la Permanencia de los Estudiantes que se desarrolla en la Universidad del Quindío. Consiste en talleres con pequeños grupos de estudiantes, orientados por un facilitador, donde se busca que cada estudiante identifique las profesiones que responden a sus habilidades y preferencias, halladas por él mismo, mediante una autoevaluación sobre las actividades que le gusta realizar, sus capacidades y las carreras que le llaman la atención. Al finalizar el taller los resultados individuales quedan en poder de cada estudiante y la idea es que se utilicen como el insumo principal para una discusión en el entorno familiar sobre la profesión o el oficio que pueda escoger el estudiante y con los resultados grupales se identifican los perfiles y aspiraciones de todos los estudiantes del departamento, de cada uno de los municipios y de cada institución educativa. Aparece una cantidad apreciable de personas que aspiran a desempeñarse en Salud, Ingenierías, Idiomas y Veterinaria, frente a un número menor con las aptitudes requeridas; muchos estudiantes muestran tener aptitudes para Artes y Trabajo Social, pero solo una tercera parte aspira a carreras relacionadas; en áreas de Administración, Derecho, Diseño, Educación, Enfermería, Gastronomía y Sicología hay un buen número de aspirantes y se equilibra con las aptitudes y preferencias.