bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction
Authors: Sugano Kentaro , Spechler Stuart Jon , El-Omar Emad M , McColl Kenneth E L , Takubo Kaiyo , Gotoda Takuji , Fujishiro Mitsuhiro , Iijima Katsunori , Inoue Haruhiro , Kawai Takashi , Kinoshita Yoshikazu , Miwa Hiroto , Mukaisho Ken-ichi , Murakami Kazunari , Seto Yasuyuki , Tajiri Hisao , Bhatia Shobna , Choi Myung-Gyu , Fitzgerald Rebecca C , Fock Kwong Ming , Goh Khean-Lee , Ho Khek Yu , Mahachai Varocha , O'Donovan Maria , Odze Robert , Peek Richard , Rugge Massimo , Sharma Prateek , Sollano Jose D , Vieth Michael , Wu Justin , Wu Ming-Shiang , Zou Duowu , Kaminishi Michio , Malfertheiner Peter 
Published: June 2022

ObjectiveAn international meeting was organised to develop consensus on (1) the landmarks to define the gastro-oesophageal junction (GOJ), (2) the occurrence and pathophysiological significance of the cardiac gland, (3) the definition of the gastro-oesophageal junctional zone (GOJZ) and (4) the causes of inflammation, metaplasia and neoplasia occurring in the GOJZ.DesignClinical questions relevant to the afore-mentioned major issues were drafted for which expert panels formulated relevant statements and textural explanations.A Delphi method using an anonymous system was employed to develop the consensus, the level of which was predefined as ≥80% of agreement. Two rounds of voting and amendments were completed before the meeting at which clinical questions and consensus were finalised.ResultsTwenty eight clinical questions and statements were finalised after extensive amendments. Critical consensus was achieved: (1) definition for the GOJ, (2) definition of the GOJZ spanning 1 cm proximal and distal to the GOJ as defined by the end of palisade vessels was accepted based on the anatomical distribution of cardiac type gland, (3) chemical and bacterial (Helicobacter pylori) factors as the primary causes of inflammation, metaplasia and neoplasia occurring in the GOJZ, (4) a new definition of Barrett’s oesophagus (BO).ConclusionsThis international consensus on the new definitions of BO, GOJ and the GOJZ will be instrumental in future studies aiming to resolve many issues on this important anatomic area and hopefully will lead to better classification and management of the diseases surrounding the GOJ.
Use of two novel trailer types for transportation of pigs to slaughter. II. Effects on trailer microclimate, pig behaviour, physiological response, and meat quality under Canadian winter conditions
Authors: Moak Kyle A.T. , Bergeron Renée , Conte Sabine , Bohrer Benjamin M. , Ferreira Guilherme Agostini , Vero Jessica Gonçalves , Aboagye Gizella , Arrazola Aitor , Devillers Nicolas , Faucitano Luigi 
Published: June 2022

In total, 3654 market pigs were transported to slaughter in winter (six replicates/treatment; January–February in southwestern Ontario) using three trailers: a modified triple-deck pot-belly (MPB), an advanced flat-deck (AFD) trailer, and a standard pot-belly (SPB). Within trailers, ambient conditions, temperature (T °C), relative humidity (RH%), and temperature humidity index (THI) were monitored in three compartments (bottom front (BF), middle middle deck (MM), and top rear (TR)). In total, 162 pigs were selected for the analysis of hematocrit, lactate, and creatine kinase (CK) levels in exsanguination blood and for the evaluation of pork quality as assessed in the longissimus (LM), semimembranosus (SM), and adductor (AD) muscles. The SPB trailer overall was approximately 2.5 °C warmer ( P = 0.01) compared to the MPB and AFD trailers while stationary at the farm. No differences ( P > 0.10) in blood variables were found between trailers. The pHu value of the SM muscle was greater ( P = 0.05) for pigs transported in the SPB trailer than in the AFD and MPB trailers. Given the few substantial effects of trailer models on animal welfare and meat quality, these three trailer models can be used indifferently for short-distance transportation in winter conditions in Canada.
Sapling growth dynamics after partial cutting in temperate mixedwood stands
Authors: Power Hugues , Auger Isabelle , Guillemette François , Raymond Patricia , Dumais Daniel 
Published: June 2022

The temperate mixedwood forests of eastern North America have been managed by partial cutting for several decades. To ensure that regeneration contributes to replacing the commercial-size stems that are removed by partial cutting, forest managers need to anticipate how saplings (i.e., regenerating trees with a diameter at breast height >1.0 cm) develop in terms of number and diameter. Using up to 20 years of monitoring data from three study sites, we developed a transition matrix model to predict the future number of saplings and their diameter distribution for mixed yellow birch ( Betula alleghaniensis Britton) – conifer stands. Our results show that partial cutting allowed yellow birch, red maple ( Acer rubrum L.), red spruce ( Picea rubens Sarg.), and balsam fir ( Abies balsamea (L.) Mill.) saplings to reach merchantable size faster and in greater numbers than in untreated control plots. We also found that fewer hardwood saplings (yellow birch and red maple) than softwood saplings (red spruce and balsam fir) were required to produce 1 m2·ha−1 of merchantable basal area after 20–40 years. Finally, our model provides a tool for forest managers to predict sapling development in mixed hardwood and softwood stands over a full cutting cycle.
Increased leaf area compensated photosynthetic downregulation in response to elevated CO2 and warming in white birch
Authors: Wang Lei , Zheng Jinping , Wang Gerong , Dang Qing-Lai 
Published: June 2022

Predicting photosynthetic acclimation to elevated CO2 and warming is difficult because they have opposite effects. We investigated physiological and morphological responses in white birch ( Betula papyrifera Marshall) to a combination of CO2 and temperature (ACT — 400 µmol·mol–1 CO2, current temperature; ECT — 750 µmol·mol–1 CO2, current + 4 °C temperature). ECT reduced photosynthesis, maximum Rubisco carboxylation ( Vcmax), maximum electron transport rate ( Jmax), photorespiration, daytime respiration, leaf N, and stomatal and mesophyll conductance, but increased biomass, height, total leaf area, electron partitioning to carboxylation and oxygenation ratio, and CO2 compensation point. The photosynthetic acclimation is consistent with the optimal carbon gain theory (carbon gain drives the coordination of carboxylation, electron transport, and respiration). While the photosynthetic acclimation was similar to acclimation to elevated CO2, ECT reduced Jmax/ Vcmax, which is consistent with the response to warming but opposite to the response to elevated CO2, suggesting that thermal acclimation may be the primary mechanism of photosynthetic acclimation to ECT and ECT probably altered N allocation between machinery for carboxylation and that for ribulose-1,5-bisphosphate regeneration. The increase in total leaf area by ECT more than offset the negative effect of photosynthetic downregulation on carbon sequestration, resulting in faster growth and greater biomass under ECT.
Image Features of Dynamic Enhanced Computed Tomography Scanning Combined with Digestive Endoscopy in the Treatment of Gastroesophageal Varices and Nursing of Esophagogastric Gastric Varices Bleeding
Authors: Ding Huijun 
Published: June 2022

The objective of this study was to investigate the application of dynamic contrast-enhanced CT images in the nursing of patients with gastroesophageal varices (GOV) treated by digestive endoscopy and its role in relieving bleeding symptoms. A total of 60 patients with liver cirrhosis and GOV were selected as the research objects. According to whether CT was used to evaluate the position of tissue adhesion embolism, the patients were divided into the control group (24 cases) and the observation group (36 cases). The treatment effect and bleeding situation of patients in the two groups were analyzed and compared. The results showed that the main portal vein pressure (

17.24
±
1.02

cmH2O), liver function recovery effect (

2.84
±
0.45

points), and total effective rate (100%) in observation group were better than those in control group (

9.70
±
1.22

cmH2O,

0.95
±
0.72

points, and 79.17%, respectively) (

P
<
0.05

). In addition, the bleeding rate in observation group (0%) was significantly lower than that in control group (16.67%) (

P
<
0.05

). In conclusion, dynamically enhanced CT scan images combined with digestive endoscopy can help improve the therapeutic effect of GOV and reduce postoperative bleeding, which was worthy of clinical application and promotion.
Pomegranate (Punica granatum) Peel Inhibits the In Vitro and In Vivo Growth of Piroplasm Parasites
Authors: Eltaysh Rasha , Rizk Mohamed Abdo , Elmishmishy Bassem , El-Sayed Shimaa Abd El-Salam , Abouelnasr Khaled , Igarashi Ikuo 
Published: June 2022

Pomegranate (Punica granatum) peel has seen a rapid surge in attention as a medical and nutritional product over the last decade. The impact of pomegranate peel methanolic extract monotherapy and combination therapy on the in vitro growth of Babesia (B.) bovis, B. bigemina, B. divergens, B. caballi, and Theileria (T.) equi, as well as B. microti in mice, was investigated in this work. Fluorescence-based SYBR green I assay was used for evaluating the inhibitory antibabesial efficacy of pomegranate (Punica granatum) peel against the growth of several piroplasm parasites in vitro and in vivo. Celltac α MEK-6450 computerized haematology analyzer was used for monitoring the haematological parameters of treated mice every 4 days. Pomegranate peel inhibited the in vitro growth of B. bovis, B. bigemina, B. divergens, T. equi, and B. caballi in a dose-dependent manner, with IC50 values of

154.45
±
23.11

,

40.90
±
9.35

,

72.71
±
14.77

,

100
±
16.20

, and

77.27
±
16.94

μ
g
/
ml

, respectively. On a B. bovis culture, the in vitro inhibitory effect of pomegranate peel was amplified when it was combined with diminazene aceturate (DA). Combination therapy of pomegranate peel and a low dose of DA (15 mg kg-1) inhibited B. microti growth significantly (

P
<
0.05

) higher than the treatment with the full dose of DA (25 mg kg-1) in B. microti-infected mice. These findings suggest that pomegranate peel might be a potential medicinal plant for babesiosis treatment, especially when combined with a low dosage of DA.
SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease
Authors: Thomas Sandhya S. , Wu Jiao , Davogustto Giovanni , Holliday Michael W. , Eckel-Mahan Kristin , Verzola Daniela , Garibotto Giacomo , Hu Zhaoyong , Mitch William E. , Taegtmeyer Heinrich 
Published: June 2022

Background:
Chronic kidney disease (CKD) is characterized by increased myocardial mass despite near-normal blood pressure, suggesting the presence of a separate trigger. A potential driver is SIRPα (signal regulatory protein alpha)—a mediator impairing insulin signaling. The objective of this study is to assess the role of circulating SIRPα in CKD-induced adverse cardiac remodeling.

Methods:
SIRPα expression was evaluated in mouse models and patients with CKD. Specifically, mutant, muscle-specific, or cardiac muscle–specific SIRPα KO (knockout) mice were examined after subtotal nephrectomy. Cardiac function was assessed by echocardiography. Metabolic responses were confirmed in cultured muscle cells or cardiomyocytes.

Results:
We demonstrate that SIRPα regulates myocardial insulin/IGF1R (insulin growth factor-1 receptor) signaling in CKD. First, in the serum of both mice and patients, SIRPα was robustly secreted in response to CKD. Second, cardiac muscle upregulation of SIRPα was associated with impaired insulin/IGF1R signaling, myocardial dysfunction, and fibrosis. However, both global and cardiac muscle–specific SIRPα KO mice displayed improved cardiac function when compared with control mice with CKD. Third, both muscle-specific or cardiac muscle–specific SIRPα KO mice did not significantly activate fetal genes and maintained insulin/IGF1R signaling with suppressed fibrosis despite the presence of CKD. Importantly, SIRPα directly interacted with IGF1R. Next, rSIRPα (recombinant SIRPα) protein was introduced into muscle-specific SIRPα KO mice reestablishing the insulin/IGF1R signaling activity. Additionally, overexpression of SIRPα in myoblasts and cardiomyocytes impaired pAKT (phosphorylation of AKT) and insulin/IGF1R signaling. Furthermore, myotubes and cardiomyocytes, but not adipocytes treated with high glucose or cardiomyocytes treated with uremic toxins, stimulated secretion of SIRPα in culture media, suggesting these cells are the origin of circulating SIRPα in CKD. Both intracellular and extracellular SIRPα exert biologically synergistic effects impairing intracellular myocardial insulin/IGF1R signaling.

Conclusions:
Myokine SIRPα expression impairs insulin/IGF1R functions in cardiac muscle, affecting cardiometabolic signaling pathways. Circulating SIRPα constitutes an important readout of insulin resistance in CKD-induced cardiomyopathy.
Epicardial HDAC3 Promotes Myocardial Growth Through a Novel MicroRNA Pathway
Authors: Jang Jihyun , Song Guang , Pettit Sarah M. , Li Qinshan , Song Xiaosu , Cai Chen-leng , Kaushal Sunjay , Li Deqiang 
Published: June 2022

Background:
Establishment of the myocardial wall requires proper growth cues from nonmyocardial tissues. During heart development, the epicardium and epicardium-derived cells instruct myocardial growth by secreting essential factors including FGF (fibroblast growth factor) 9 and IGF (insulin-like growth factor) 2. However, it is poorly understood how the epicardial secreted factors are regulated, in particular by chromatin modifications for myocardial formation. The current study is to investigate whether and how HDAC (histone deacetylase) 3 in the developing epicardium regulates myocardial growth.

Methods:
Various cellular and mouse models in conjunction with biochemical and molecular tools were employed to study the role of HDAC3 in the developing epicardium.

Results:

We deleted
Hdac3
in the developing murine epicardium, and mutant hearts showed ventricular myocardial wall hypoplasia with reduction of epicardium-derived cells. The cultured embryonic cardiomyocytes with supernatants from
Hdac3
knockout (KO) mouse epicardial cells also showed decreased proliferation. Genome-wide transcriptomic analysis revealed that
Fgf9
and
Igf2
were significantly downregulated in
Hdac3
KO mouse epicardial cells. We further found that
Fgf9
and
Igf2
expression is dependent on HDAC3 deacetylase activity. The supplementation of FGF9 or IGF2 can rescue the myocardial proliferation defects treated by
Hdac3
KO supernatant. Mechanistically, we identified that microRNA (miR)-322 and miR-503 were upregulated in
Hdac3
KO mouse epicardial cells and
Hdac3
epicardial KO hearts. Overexpression of miR-322 or miR-503 repressed FGF9 and IGF2 expression, while knockdown of miR-322 or miR-503 restored FGF9 and IGF2 expression in
Hdac3
KO mouse epicardial cells.

Conclusions:
Our findings reveal a critical signaling pathway in which epicardial HDAC3 promotes compact myocardial growth by stimulating FGF9 and IGF2 through repressing miR-322 or miR-503, providing novel insights in elucidating the etiology of congenital heart defects and conceptual strategies to promote myocardial regeneration.
Exploring Methodological Challenges in Deliberative Democracy
Authors: Veri Francesco 
Published: June 2022

Abstract
This article analyses the current methodological debate within the field of deliberative democracy and provides some analytical suggestions about the research and methodological directions to analyze the field by considering theory falsifiability. The analysis follows three separate steps. First, the author specifies the field’s status regarding theory falsifiability. Then he classifies a purposive sample of scholars’ research in deliberative democracy into a specific methodological taxonomy. Finally, through configurational meta-analysis, he examines deliberative democracy considering the systemic turn. The results of the analysis suggest the use of mixed or set-theoretical methods are the most promising analytical approaches to examine the field from a theory falsifiability perspective.
Was the Arab Spring a Post-Islamist Moment?
Authors: Vaughan Kenneth R. , Froese Paul , Lonas Chase 
Published: June 2022

Abstract
Scholars continue to debate political motives behind the Arab Spring – a debate that centers on the compatibility of democratic and Islamist preferences. Some frame the protests as a boon for democracy and prudential needs of citizens. Others report an Islamist turn against secular autocracies. Here, the authors argue that this framing relies on outdated civilizational narratives and that democratic, Islamist, and prudential concerns present concurrently in the Arab Spring. Using the Arab Democracy Barometer, the authors investigate public opinion in Egypt, Libya, and Tunisia, to estimate evaluations of the Arab Spring. Democratically oriented Egyptians and Libyans were more favorable toward the events, while Tunisians with Islamists preferences were more optimistic. The authors find little evidence of tensions between Islamism and democracy. This is particularly salient when evaluating attitudes about the Arab Spring. The authors argue that the Arab Spring constitutes a “post-Islamist” movement, one which integrates democratic and Islamist preferences into a revolutionary framework.
Bissu’s Transvestites in the Buginese-Makassar Tradition through the Transformation of Faisal Oddang’s Literary Works: An Intertextuality Study
Authors: Hariyono Saharul , Bewe Nurhadi 
Published: June 2022

Abstract
Writer Faisal Oddang narrated the existence of the bissu community seemingly reconstructed from an understanding of the historical text to become more colorful. This article questions how the transformation model of bissu community figures is revealed in Oddang’s fictional work. This study utilizes Julia Kristeva’s intertext abstracted through ideologeme as a text arrangement that refers to the space of exterior texts (semiotic practice). The results of the study show: first, how the transformation model of the bissu community character appears in the work of fiction; second, the libido of bissu community in their sacred place; third, the bissu community character from marginalized positions fighting injustice against Darul Islam/Indonesia Islamic Army rebels both physically and verbally; fourth, the negotiation of bissu community leaders saving the faith by syncretism with Islam over the religious purification incident. Therefore, in fiction, the character of the bissu community shows both opposition and resistance.
Auto-Part Terms in Thai: a Cognitive Semantic Analysis
Authors: Wongwattana Unchalee Singnoi 
Published: June 2022

Abstract
This article presents an investigation of Thai auto-part terms in Cognitive Semantics. With at least 1,000 auto-part terms in our data analysis, we argue that the conceptual naming strategy is linguistically effective in understanding auto parts in the Thai culture. Metaphorically, the resemblance operation enhances the degree of lexical richness by enabling the auto-part conceptualization with four source domains: surrounding object, animal, human, and plant. Metonymically, source domains such as shape, function, part, material, position, involved organ, motion, sound and space function in the source-in-target operation, and the category machine/ device appears as a source domain in the target-in-source operation. The article not only verifies and supports the cognitive theory that holds that language is part of the cognitive abilities of humans in general, and thus describes the world as people understand it, but also sheds light on the association to a further pragmatic analysis of implicature.
Significance and Values of the Cathedral of the Immaculate Conception, Ubon Ratchathani, Thailand
Authors: Boonmee Lalida 
Published: June 2022

Abstract
Physical change in religious architecture has an effect on perception of the building’s historical value and significance. This article discusses the case of the physical transformation of the Cathedral of the Immaculate Conception which has undergone four successive changes in architectural characteristics since Christianity was first established in the area in 1881. Methodologically, this study comprises a review of historical documents and interviews with Christians who live in the cathedral’s neighbouring areas. The result shows that the cathedral is significant for local residents as a centre of Christianity and beliefs which have been handed down through generations. From the beginning of its establishment, the cathedral has continually been used for social gatherings in religious activities, therefore, in spite of physical changes, its social and functional values still remain unchanged. Overall, the historical significance of the cathedral to the historic urban landscape of Ubon Ratchathani lies in its intangible rather than its tangible value.
Origins of Intraseasonal Precipitation Variability over North China in the Rainy Season
Authors: Gao Yingxia , Hsu Pang-Chi , Che Shaojing , Yu Changwen , Han Shiru 
Published: June 2022

Abstract
We investigated the characteristics and mechanisms of subseasonal precipitation variability in North China during the rainy season (June–September). Two dominant intraseasonal modes with periods of 8–20 and 30–60 days were identified via spectral analysis. Together, they explain 62.8% of the total precipitation variability. Nearly all persistent heavy rainfall events in North China were observed concurrently with the enhanced positive phases of biweekly or/and 30–60-day precipitation modes. To elucidate the origins of these two intraseasonal precipitation variabilities, we performed moisture and vertical motion analyses. The moisture diagnosis results show that the anomalous lower-level southerly perturbations, which transport the background summer-mean moisture from the tropical areas toward North China, are the key process causing abundant moisture for the anomalous precipitation occurrence. The local ascending motion anomalies associated with the occurrence of intraseasonal precipitation come mainly from the anomalous vorticity advection induced by summer-mean thermal wind. Although the key processes causing the precipitation anomalies of these two intraseasonal modes are similar, the geneses and evolutions of large-scale conditions associated with them are distinct. The biweekly circulation and convective anomalies are driven by the midlatitude wave train pattern propagating southeastward across the Eurasian continent, while the 30–60-day anomalies are determined by both upper-level perturbations along 40°N and northward-propagating intraseasonal convective activities from the tropics.