bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Inorganic Pac‐Man: Synthesis, structure and electrochemical studies of a heterometallic {YCoII3W} cluster sandwiched by two germanotungstates
Authors: Ibrahim Masooma , Mbomekallé Israël M. , de Oliveira Pedro , Bergfeldt Thomas , Anson Christopher E. 
Published: July 2022

AbstractA new heterometallic sandwich‐type Keggin polyoxometalate, [(GeW9O34)2{YCo(W=O)(μ3‐O)(μ3‐OH)(μ2‐O)(μ2‐OH2)(OH2)(C2H3O2)}]13− has been synthesized by a simple reaction method. The isolated compound has been structurally characterized by single crystal X‐ray diffraction (SC‐XRD), Fourier transform infrared (FTIR) spectroscopy, elemental analysis, and thermogravimetric (TG) analysis. In addition, electrochemical properties have been investigated in detail. The X‐ray structure of this POM reveals that a unique heterometallic core {YCo3(W=O)(μ3‐O)(μ3‐OH)(μ2‐O)(μ2‐OH2)(OH2)(OAc)}7+ is sandwiched between two [GeW9O34]10− ligands, giving rise to the first example of a heterometallic core composed of 3d–4d–5d transition metal ions.
Gravimetric Geoid Modeling by Stokes and Second Helmert’s Condensation Method in Yogyakarta, Indonesia
Authors: Bramanto Brian , Prijatna Kosasih , Fathulhuda Muhammad Syahrullah , Pahlevi Arisauna Maulidyan 
Published: July 2022

Abstract
Since the last decade, Indonesia has continuously improved the accuracy of the national geoid model by conducting rapid gravity acquisition using airborne and terrestrial gravimetry. As gravity data have been collected thoroughly in all regions, the time has come to carry out Indonesia’s geoid modeling. We started our study by employing the Stokes and Second Helmert’s condensation method to our terrestrial gravity data in Yogyakarta, Indonesia, with a target area of 1∘× 1∘. The computation was based on the commonly applied remove-compute-restore process. We used a satellite-only geopotential model of GO_CONS_GCF_2_TIM_R6 up to degree 300 to remove and restore the long-wavelength part of the gravity field within the modeling process. Numerical results show that few cm of geoid model accuracy was achieved when we compared it to the validation points. Also, our best performance geoid is estimated to be better than the Earth Gravitational Model 2008 (EGM2008) geoid model by up to 2.8 cm in terms of standard deviation.
Waste Recycling and Repurposing to Address SDG 11 in Burkina Faso: Do Multi-stakeholder Platforms Matter?
Authors: Sanfo Safiétou , Neya Oblé , Da Sylvestre , Salack Seyni , Amikuzuno Joseph , Gandaa Bizoola Zinzoola , Hackman Kwame Oppong , Ogunjobi Kehinde Olufunso 
Published: July 2022

AbstractPoor waste management and uncontrolled waste disposal cause pollution and blocked drainage facilities, leading to flooding and water stagnation, increasing the risk of diseases, and eroding local progresses toward achieving the Sustainable Development Goals (SDGs). Recycling and repurposing liquid and solid waste for urban and periurban agriculture, green spaces, and green energy on the other hand benefit social and ecosystem resilience and can contribute to SDG11. This chapter considers the uneven progress in Burkina Faso where the transgressive behavior of garbage producers leads to illegal garbage dumping, equipment obsolescence, insufficient maintenance, and the lack of support from authorities. We show how the creation of a participatory Multi-Stakeholder Platform (MSP) can lead to better collection, recycling, and repurposing of wastes. The results showed that (1) the practice of liquid and solid waste management involves several interacting stakeholders, (2) these interactions generate complex problems hardly resolved by a single (few) stakeholder(s), and (3) an MSP is a good approach toward solving these complex problems.
Four-point correlators of light-ray operators in CCFT
Authors: Hu Yangrui , Lippstreu Luke , Spradlin Marcus , Srikant Akshay Yelleshpur , Volovich Anastasia 
Published: July 2022

Abstract
We compute the four-point correlator of two gluon light-ray operators and two gluon primaries from the four-gluon celestial amplitude in (2, 2) signature spacetime. The correlator is non-distributional and allows us to verify that light-ray operators appear in the OPE of two gluon primaries. We also carry out a conformal block decomposition of the terms involving the exchange of gluon operators.
Phenomenological analysis of multi-pseudoscalar mediated dark matter models
Authors: Banerjee Shankha , Bélanger Geneviève , Bhatia Disha , Fuks Benjamin , Raychaudhuri Sreerup 
Published: July 2022

Abstract
Non-minimal simplified extensions of the Standard Model have gained considerable currency in the context of dark matter searches at the LHC, since they predict enhanced mono-Higgs and mono-W/Z signatures over large parts of the parameter space. However, these non-minimal models obviously lack the simplicity and directness of the original simplified models, and are more heavily dependent on the model assumptions. We propose to classify these models generically on the basis of additional mediator(s) and dark matter particles. As an example, we take up a scenario involving multiple pseudoscalar mediators, and a single Dirac dark matter particle, the latter being a popular introduction to ensure ultraviolet completion of theories with multiple pseudoscalar fields. In the chosen scenario, we discuss the viable channels and signatures of relevance at the future runs of the LHC. These are then compared with the minimal simplified scenarios and distinguishing features are pinpointed.
Cyclists and autonomous vehicles at odds
Authors: Gaio Alexander , Cugurullo Federico 
Published: July 2022

AbstractConsequential historical decisions that shaped transportation systems and their influence on society have many valuable lessons. The decisions we learn from and choose to make going forward will play a key role in shaping the mobility landscape of the future. This is especially pertinent as artificial intelligence (AI) becomes more prevalent in the form of autonomous vehicles (AVs). Throughout urban history, there have been cyclical transport oppressions of previous-generation transportation methods to make way for novel transport methods. These cyclical oppressions can be identified in the baroque and modernist periods, and a third oppression may occur in the contemporary period. To explore the idea of a third oppression, we focus on the bicycle and outline the history of cycling to understand how historical mode oppression unfolded. We then present several social and political factors that contributed to the oppression of cycling and share recommendations for how to avoid future oppressions including political, social, and design actions for researchers and policymakers to take. This paper argues that priorities for AI-enabled mobility and cyclist needs be advanced in proportion to the extent that they contribute to societal goals of urban containment, public realm, and proximal cities. Additionally, future mobility evolutions should prioritise mobility justice and mode choice over inducing a singular transportation method.
Model averaging for sparse seemingly unrelated regression using Bayesian networks among the errors
Authors: Salam Abdul , Grzegorczyk Marco 
Published: July 2022

AbstractMultivariate Bayesian linear regression (MBLR) is a popular statistical tool with many applications in a variety of scientific fields. However, a shortcoming is potential model over-complexity, as the model assumes that all responses depend on the same covariates and that all errors are mutually pairwise correlated. The class of Bayesian seemingly unrelated regression (SUR) models generalizes the class of MBLR models by allowing for response-specific covariate sets. In a recent work it has been proposed to employ Gaussian graphical models for learning sparse SUR (SSUR) models with conditional independencies among the errors. The proposed SSUR model infers undirected edges among the errors, and the proposed Reversible Jump Markov Chain Monte Carlo (RJMCMC) inference algorithm relies on approximations of the marginal likelihoods. In this paper, we propose a new refined SSUR model that replaces the undirected graphs (Gaussian graphical models) by directed acyclic graphs (Gaussian Bayesian networks). Unlike the earlier proposed model, our new model is therefore able to learn some directed edges among the errors. And we derive a RJMCMC algorithm that does not require approximations of the marginal likelihoods. In particular, we present an algorithm for sampling covariance matrices that are coherent with a given directed acyclic graph. The proposed RJMCMC algorithm allows for exact Bayesian model averaging across both: the response-specific covariate sets and the directed acyclic graphs.
X-ray multiscale 3D neuroimaging to quantify cellular aging and neurodegeneration postmortem in a model of Alzheimer’s disease
Authors: Barbone Giacomo E. , Bravin Alberto , Mittone Alberto , Pacureanu Alexandra , Mascio Giada , Di Pietro Paola , Kraiger Markus J. , Eckermann Marina , Romano Mariele , Hrabě de Angelis Martin , Cloetens Peter , Bruno Valeria , Battaglia Giuseppe , Coan Paola 
Published: July 2022

Abstract

Purpose

Modern neuroimaging lacks the tools necessary for whole-brain, anatomically dense neuronal damage screening. An ideal approach would include unbiased histopathologic identification of aging and neurodegenerative disease.

Methods
We report the postmortem application of multiscale X-ray phase-contrast computed tomography (X-PCI-CT) for the label-free and dissection-free organ-level to intracellular-level 3D visualization of distinct single neurons and glia. In deep neuronal populations in the brain of aged wild-type and of 3xTgAD mice (a triply-transgenic model of Alzheimer’s disease), we quantified intracellular hyperdensity, a manifestation of aging or neurodegeneration.

Results
In 3xTgAD mice, the observed hyperdensity was identified as amyloid-β and hyper-phosphorylated tau protein deposits with calcium and iron involvement, by correlating the X-PCI-CT data to immunohistochemistry, X-ray fluorescence microscopy, high-field MRI, and TEM. As a proof-of-concept, X-PCI-CT was used to analyze hippocampal and cortical brain regions of 3xTgAD mice treated with LY379268, selective agonist of group II metabotropic glutamate receptors (mGlu2/3 receptors). Chronic pharmacologic activation of mGlu2/3 receptors significantly reduced the hyperdensity particle load in the ventral cortical regions of 3xTgAD mice, suggesting a neuroprotective effect with locoregional efficacy.

Conclusions
This multiscale micro-to-nano 3D imaging method based on X-PCI-CT enabled identification and quantification of cellular and sub-cellular aging and neurodegeneration in deep neuronal and glial cell populations in a transgenic model of Alzheimer’s disease. This approach quantified the localized and intracellular neuroprotective effects of pharmacological activation of mGlu2/3 receptors.
Community as Governor: Exploring the role of Community between Industry and Government in SLO
Authors: Poelzer Gregory , Frimpong Rosette , Poelzer Greg , Noble Bram 
Published: July 2022

AbstractFor many natural resource projects, the impact on Indigenous communities is a primary concern. Therefore, governance arrangements that account for the interests of companies, communities, and government are critical for the project’s success. This paper looked at two successful mining projects in northern Canada, McArthur River and Diavik, to examine the governance arrangement that led to mutually beneficial outcomes. Through an analysis of interviews and documents, we assessed both governing institutions and interactions to understand how the respective companies and communities established a high level of trust. In both cases, government took a less prominent role in the management of resources, allowing the Indigenous communities to hold a stronger role in the governance of the resources. Both Indigenous communities, therefore, built partnerships with the company around socio-economic benefits along with environmental monitoring – redefining ‘community’ in governance arrangements.
Safety of Prophylactic Anticoagulation During Bedside Procedures: A Prospective Multicenter Observational Study
Authors: Barton Cassie A. , Shapiro David S. , Webb Andrew J. , Gontarz Brendan , Schreiber Martin 
Published: July 2022

AbstractBackgroundBedside percutaneous dilatational tracheostomy (PDT) and percutaneous endoscopic gastrostomy (PEG) are common procedures performed in the intensive care unit (ICU). Venous thromboembolism (VTE) prophylaxis is frequently prescribed to ICU patients and it remains unclear whether pre‐procedure discontinuation is necessary.MethodsThis multi‐center prospective observational study aimed to describe bleeding rates in patients undergoing bedside PEG or PDT who did or did not have VTE prophylaxis held. Decision to hold prophylaxis was made by the operating physician. The primary endpoint was the rate of peri‐procedural bleeding complications. Secondary endpoints included quantification of held doses in the peri‐procedural period, rate of venous thromboembolism, and characteristics associated with having prophylaxis held.Results91 patients were included over a 2‐year period. Patients were on average aged 54 years, 40% female, mostly admitted to the trauma service (59%), and most commonly underwent bedside PDT (59%). Overall, 21% of patients had doses of pre‐procedure prophylaxis held. Bleeding events occurred in 1 patient (1.4%) who had prophylaxis continued and in 1 patient (5.0%) who had prophylaxis held, a rate difference of 3.6% (95% CI–9.5%, 16.7%). One bleeding event was managed with bedside surgical repair and one with blood transfusion. There were 10 VTE events, all of whom had prophylaxis continued during the pre‐procedure period but 3 had prophylaxis held after the procedure.ConclusionsBleeding complications were rare and did not significantly differ depending on whether prophylaxis was held or not. Future research is required to confirm the lack of risk with continuing prophylaxis through bedside procedures.
Incidental findings on routine preoperative noncontrast chest computed tomography and chest radiography prior to cardiac surgery in the multicenter randomized controlled CRICKET study
Authors: Knol Wiebe G. , den Harder Annemarie M. , de Heer Linda M. , Benke Kálmán , Maurovich-Horvat Pál , Leiner Tim , Merkely Béla , Krestin Gabriel P. , Bogers Ad J.J.C. , Budde Ricardo P.J. 
Published: July 2022

Abstract
Objective
To describe the prevalence and consequences of incidental findings when implementing routine noncontrast CT prior to cardiac surgery.

Methods
In the multicenter randomized controlled CRICKET study, 862 adult patients scheduled for cardiac surgery were randomized 1:1 to undergo standard of care (SoC), which included a chest-radiograph, or an additional preoperative noncontrast chest CT-scan (SoC+CT). In this subanalysis, all incidental findings detected on the chest radiograph and CT-scan were analyzed. The influence of smoking status on incidental findings was also evaluated, adjusting for sex, age, and group allocation.

Results
Incidental findings were observed in 11.4% (n = 49) of patients in the SoC+CT group and in 3.7% (n = 16) of patients in the SoC-group (p < 0.001). The largest difference was observed in findings requiring follow-up (SoC+CT 7.7% (n = 33) vs SoC 2.3% (n = 10), p < 0.001). Clinically relevant findings changing the surgical approach or requiring specific treatment were observed in 10 patients (1.2%, SoC+CT: 1.6% SoC: 0.7%), including lung cancer in 0.5% of patients (n = 4) and aortic dilatation requiring replacement in 0.2% of patients (n = 2). Incidental findings were more frequent in patients who stopped smoking (OR 1.91, 1.03–3.63) or who actively smoked (OR 3.91, 1.85–8.23).

Conclusions
Routine CT-screening increases the rate of incidental findings, mainly by identifying more pulmonary findings requiring follow-up. Incidental findings are more prevalent in patients with a history of smoking, and preoperative CT might increase the yield of identifying lung cancer in these patients. Incidental findings, but not specifically the use of routine CT, are associated with delay of surgery.

Key Points
• Clinically relevant incidental findings are identified more often after a routine preoperative CT-scan, when compared to a standard of care workup, with some findings changing patient management.
• Patients with a history of smoking have a higher rate of incidental findings and a lung cancer rate comparable to that of lung cancer screening trials.
• We observed no clear delay in the time to surgery when adding routine CT screening.
KNTC1 as a putative tumor oncogene in pancreatic cancer
Authors: Liu Ling , Chen Hongwei , Chen Xinan , Yao Chenjie , Shen Weimin , Jia Changku 
Published: July 2022

Abstract
Purpose
Recent studies have demonstrated that kinetochore-associated protein 1 (KNTC1) plays a significant role in the carcinogenesis of numerous types of cancer. This study aimed to explore the role and possible mechanisms of KNTC1 in the development of pancreatic cancer.

Methods and results
We analyzed differentially expressed genes by RNA sequencing in three paired pancreatic cancer and para-cancerous tissue samples and found that the expression of KNTC1 was significantly upregulated in pancreatic cancer. A Cancer and Tumor Gene Map pan-analysis showed that high expression of KNTC1 was related to poor prognosis in 9499 tumor samples. With immunohistochemical staining, we found that the high expression of KNTC1 in pancreatic cancer was related to pathological grade and clinical prognosis. Similarly, RT-PCR results indicated that the expression of KNTC1 was higher in three groups of pancreatic cancer cell lines (BxPC-3, PANC-1, and SW1990) than in normal pancreatic ductal cells. We introduced lentivirus-mediated shRNA targeting KNTC1 into PANC-1 and SW1990 cells and found that KNTC1 knockdown significantly decreased cell growth and increased cell apoptosis compared to the control group cells. Bioinformatic analysis of the cell expression profile revealed that differential genes were mainly enriched in the cell cycle, mitosis, and STAT3 signaling pathways, and co-immunoprecipitation confirmed an interaction between KNTC1 and cell division cycle associated 8.

Conclusions
KNTC1 could be linked to the pathophysiology of pancreatic cancer and may be an early diagnostic marker of cervical precancerous lesions.
Mortality and cancer in eosinophilic gastrointestinal disorders distal to the esophagus: nationwide cohort study 1990–2017
Authors: Bledsoe Adam C. , Garber John J. , Ye Weimin , Roelstraete Bjorn , Murray Joseph A. , Ludvigsson Jonas F. 
Published: July 2022

Abstract
Background
Eosinophilic gastrointestinal disorders (EGIDs) include inflammatory conditions with enteric infiltration of eosinophils and resulting symptoms. This study aims to examine a population-based sample of patients for prevalence, mortality, and cancer risk in EGIDs distal to the esophagus.

Methods
Nationwide, population-based cohort study. EGID was identified through relevant biopsy codes from Sweden’s all 28 pathology departments through the ESPRESSO cohort. Individuals with EGID were then matched to general population reference individuals with similar age and sex. Study participants were linked to Swedish healthcare registers. Through Cox regression, we calculated adjusted hazard ratios (aHRs) adjusting for sex, age, county, calendar period, and education.

Results
In total, 2429 patients (56% female) were found to have EGID distal to the esophagus, representing a prevalence of about 1/4800 in the Swedish population. Mean age was 44 years with 11% children at the time of diagnosis. Mortality was increased 17% in patients with EGIDs compared to reference individuals (aHR = 1.17; 95%CI = 1.04–1.33). Excess mortality was seen in gastric and small bowel eosinophilic disease, but not colonic disease (aHR = 1.81; 95%CI = 1.32–2.48, aHR = 1.50; 95%CI = 1.18–1.89, and aHR = 0.99; 95%CI = 0.85–1.16, respectively). Cause specific mortality was driven by cancer-related death (aHR = 1.33; 95%CI = 1.05–1.69). However, this study failed to show an increase in incident cancers (aHR = 1.14; 95%CI = 0.96–1.35). Comparison of EGID individuals with their siblings yielded similar aHRs.

Conclusions
This study found an increased risk of death in patients with EGIDs distal to the esophagus, with cancer death driving the increase. Proximal gut disease seems to confer the greatest risk. There was no increase in incident cancers.
Synthesis, characterization, and thermal and computational investigations of the l-histidine bis(fluoride) crystal
Authors: Reis Ian Felipe Sousa , Viana Jailton Romão , de Oliveira Neto João Gomes , Stoyanov Stanislav R. , de M. Carneiro José Walkimar , Lage Mateus Ribeiro , dos Santos Adenilson Oliveira 
Published: July 2022

AbstractNonlinear optical materials have been investigated recently due to their potential technological applications in information storage and communications. In this context, semi-organic crystals can effectively combine the desired nonlinear optical properties of amino acids with the promising mechanical and thermal properties of inorganic materials. In this work, we have synthesized and characterized a semi-organic crystal of the amino acid l-histidine and hydrofluoric acid and investigated the chemical interactions between the organic and inorganic moieties. The crystal of l-histidine bis(fluoride) has been produced by slow solvent evaporation and characterized by X-ray diffraction (XRD) crystallography and thermogravimetric and differential thermal analyses. The XRD conducted using the Rietveld method shows that the unit cell is orthorhombic with the P21212 space group and contains four l-histidine bis(fluoride) units. Both differential thermal analysis and temperature-dependent XRD show that the crystals are thermally stable up to 191°C and do not undergo phase transition. The computational Hirshfeld surface analysis of the crystal structure reveals the main intermolecular interactions. Density functional theory has been employed to calculate the ionic interaction energy and electrostatic potential maps and confirm the spontaneity of ionic association at 191°C. The combined experimental and computational results show that the thermal stability of the semi-organic l-histidine bis(fluoride) crystal makes it suitable for nonlinear optical applications in optical sensing and communication systems.
Graphical abstract