bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local-feature and global-dependency based tool wear prediction using deep learning
Authors: Yang Changsen , Zhou Jingtao , Li Enming , Wang Mingwei , Jin Ting 
Published: August 2022

AbstractEvaluation of tool wear is vital in manufacturing system, since early detections on worn-out condition can ensure workpiece quality, improve machining efficiency. With the development of intelligent manufacturing, tool wear prediction technology plays an increasingly important role. However, traditional tool wear prediction methods rely on experience and knowledge of experts and are labor-extensive. Deep learning provides an effective way to extract features of raw data and establish the mapping relationship between features and targets automatically. In this paper, a new local-feature and global-dependency based tool wear prediction method is proposed. It is a hybrid approach combining manual features with automatic features. Firstly, an enhanced CNN network is designed and applied on the transformed wavelet scalogram to learn the local single-scale specific features and multi-scale correlation features automatically. Secondly, sequence of local feature vectors combining manual features with automatic features are fed into multi-layer LSTM step by step for the global dependency. A fully connected layer is then trained to predict tool wear. Finally, two statistics are proposed to illustrate the overall prediction performance and generalization ability of the model. An experiment illustrates the effectiveness of our proposed method under multiple working conditions.
Fourth thoracic vertebra as landmark for depth of right internal jugular vein catheterization in infants
Authors: Liu Guoliang , Zhang Jianmin , Wang Fang , Liu Heqi 
Published: August 2022

AbstractThe carina is considered a reliable marker for the depth of right internal jugular vein catheterization in infants on chest radiograph. In adult anatomy, the carina is typically located at the level of the fifth thoracic vertebra. We are not aware of a positional relationship between infant carina and thoracic vertebrae. Thus, we evaluated that a vertebral body may be at the same level as carina and can be as radiographic landmarks for the depth of right internal jugular vein catheterization in infants. In this retrospective analysis, 108 infants (aged 1–12 months) who underwent congenital heart surgery between January 1, 2019 and June 30, 2019 were included. We analyzed the post-operative chest radiographs of those who underwent right internal jugular vein catheterization and assessed the positional relationship of the carina and vertebral bodies. We measured the vertical distance of the central venous catheter (CVC) catheter tip from the carina (below the carina 22 mm, it may be close to or into the right atrium). In total, 95 children were enrolled; The carina was located at the third thoracic vertebra in two cases (2%) and at the fourth thoracic vertebra in 93 cases (98%). The distance between the tip of CVC and the carina was 10 (4, 15) mm, and 6.3% (6 cases) had the catheter tip at more than 22 mm below the carina. Most fourth thoracic vertebrae were at the same level as the carina on chest radiographs. Therefore, it has potential as a radiographic landmark for the depth of right internal jugular vein catheterization in infants on chest radiograph.
The response of grain yield and ear differentiation related traits to nitrogen levels in maize varieties with different nitrogen efficiency
Authors: Ma Baoxin , Wang Junqiang , Han Yehui , Zhou Chao , Xu Ting , Qu Zhongcheng , Wang Lida , Ma Bo , Yuan Ming , Wang Lianxia , Ding Xinying , Qian Chunrong 
Published: August 2022

AbstractMaize (Zea mays L.) is one of the most widely distributed and important crops in China. Maize ear differentiation plays an important role grain yield formation. However, it is unclear if ear and root morphophysiology status affects yield formation by altering ear differentiation and development under different nitrogen (N) conditions. The aim of this study is to understand how the ear differentiation and development are affected by ear and root morphophysiology traits, as affected by the N rate. The experiment consisted of two N rates: high nitrogen (180 kg ha−1), and low nitrogen (60 kg ha−1). Two N-efficient varieties (NEVs) and two N-inefficient varieties (NIVs) were grown in the field. The results showed higher nitrogen accumulation and grain yield in NEVs than in NIVs, which was mainly attributed to the increased N uptake by the larger root system under both N conditions. Under high N conditions, among ear differentiation-related traits, only FR was significantly positively correlated with grain yield, and NEVs ensure FR through higher N concentration and ZR content in ear at the fertilization stage. Under low N conditions, NEVs obtained higher FP, SR and FR through higher N concentration and IAA in ear at the early stage of ear differentiation, maintained lower AR and BTL by higher RA, R-ZR and E-ZR at the late stage of ear growth. These results suggest that NEVs have a more complex mechanism for obtaining higher grain yield under low N conditions than N sufficiency, and that phytohormones play an important role in this process.
A cross-sectional survey on awareness of cancer risk factors, information sources and health behaviors for cancer prevention in Japan
Authors: Yamagiwa Yoko , Tanaka Shiori , Abe Sarah Krull , Shimazu Taichi , Inoue Manami 
Published: August 2022

AbstractDue to recent increases in cancer burden worldwide, we investigated current awareness of cancer risk factors and the association between information sources and health behaviors for cancer prevention in Japan. A nationwide representative sample aged 20 years or older (563 men and 653 women) responded to a questionnaire as part of a population-based survey in December 2018. Tobacco smoking (55.7% of the mean attributable fraction of cancer risk overall) and cancer-causing infection (52.0%) were regarded more highly than other lifestyle factors as causes of cancer (obesity [36.6%], physical inactivity [31.9%], unbalanced diet [30.9%], and alcohol consumption [26.2%]). The association between information sources and health behaviors for cancer prevention was evaluated using a logistic regression model. The websites of public institutions, and health professionals were associated with a broad range of health behaviors including improving diet, exercise, cancer screening/health check-up, and abstinence from smoking/drinking. Among sources of print media, positive associations were observed between books and improving diet/exercise, brochures and cancer screening/health check-up, and advertisements and abstinence from smoking/drinking. A strategic health communication approach that utilizes various information sources and delivery channels is needed to inform the public about cancer prevention and to motivate risk-reducing behaviors in the population.
QOGMP: QoS-oriented global multi-path traffic scheduling algorithm in software defined network
Authors: Guo Yiping , Hu Guyu , Shao Dongsheng 
Published: August 2022

AbstractAccording to the research status of Software Defined Network (SDN) control layer traffic scheduling, we find the current common problems, including single path, easy congestion, Quality of Service (QoS) requirements and high delay. To solve these four problems, we design and implement a QoS-oriented global multi-path traffic scheduling algorithm for SDN, referred to as QOGMP. First, we propose a link weight calculation algorithm based on the idea of traction links and deep reinforcement learning, and conduct experimental verifications related to traction links. The algorithm considers QoS requirements and alleviates the problems of easy congestion and high delay. Then, we propose a traffic scheduling algorithm based on link weight and multi-path scheme, which also considers QoS requirements and solves the problem of single path. Finally, we combined the link weight calculation algorithm and the traffic scheduling algorithm to implement QOGMP, and carried out comparative experiments in the built simulation environment. The experimental results show that QOGMP is better than the two comparison algorithms in terms of delay and rescheduling rate.
Feasibility of a registry for standardized assessment of long-term and late-onset health events in survivors of childhood and adolescent cancer
Authors: Otth Maria , Drozdov Daniel , Scheinemann Katrin 
Published: August 2022

AbstractChildhood and adolescent cancer survivors are at risk for chronic medical conditions. Longitudinal studies help to understand their development and course. We hypothesize that collecting follow-up data according to the modified CTCAE criteria and embedded in regular care, is feasible and results in a rich database. We recruited 50 Swiss survivors treated at our institution between 1992 and 2015, who completed their treatment and are still alive. Information on cancer diagnosis, treatment, and medical conditions from follow-up visits, graded according to the modified CTCAE criteria, were added in the database. We described the cohort, assessed the prevalence of medical conditions at the most recent visits and the time needed for data entry. Survivors had a median age of 10 years at diagnosis with 16 years of follow-up. 94% of survivors suffered from at least one medical condition. We registered 25 grade 3 or 4 conditions in 18 survivors. The time needed for data entry at enrollment was < 60 min in most survivors and much less for follow-up visits. Standardized assessment of medical conditions is feasible during regular clinical care. The database provides longitudinal real-time data to be used for clinical care, survivor education and research.
mTOR regulation of metabolism limits LPS-induced monocyte inflammatory and procoagulant responses
Authors: Lund Nina C. , Kayode Yetunde , McReynolds Melanie R. , Clemmer Deanna C. , Hudson Hannah , Clerc Isabelle , Hong Hee-Kyung , Brenchley Jason M. , Bass Joseph , D’Aquila Richard T. , Taylor Harry E. 
Published: August 2022

AbstractTranslocated lipopolysaccharide (LPS) activates monocytes via TLR4 and is hypothesized to increase cardiovascular disease risk in persons living with HIV. We tested whether mTOR activity supports LPS-stimulated monocyte production of pro-inflammatory cytokines and tissue factor (TF), as it propels the inflammatory response in several immune cell types besides monocytes. However, multi-omics analyses here demonstrate that mTOR activates a metabolic pathway that limits abundance of these gene products in monocytes. Treatment of primary human monocytes with catalytic mTOR inhibitors (mTORi) increased LPS-induced polyfunctional responses, including production of IL-1β, IL-6, and the pro-coagulant, TF. NF-κB-driven transcriptional activity is enhanced with LPS stimulation after mTORi treatment to increase expression ofF3(TF). Moreover, intracellular NAD+availability is restricted due to decreased salvage pathway synthesis. These results document mTOR-mediated restraint of the LPS-induced transcriptional response in monocytes and a metabolic mechanism informing strategies to reverse enhanced risk of coagulopathy in pro-inflammatory states.
MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine
Authors: Fets Louise , Bevan Natalie , Nunes Patrícia M. , Campos Sebastien , dos Santos Mariana Silva , Sherriff Emma , MacRae James I. , House David , Anastasiou Dimitrios 
Published: August 2022

Abstractα-ketoglutarate (αKG) is a central metabolic node with a broad influence on cellular physiology. The αKG analogue N-oxalylglycine (NOG) and its membrane-permeable pro-drug derivative dimethyl-oxalylglycine (DMOG) have been extensively used as tools to study prolyl hydroxylases (PHDs) and other αKG-dependent processes. In cell culture media, DMOG is rapidly converted to MOG, which enters cells through monocarboxylate transporter MCT2, leading to intracellular NOG concentrations that are sufficiently high to inhibit glutaminolysis enzymes and cause cytotoxicity. Therefore, the degree of (D)MOG instability together with MCT2 expression levels determine the intracellular targets NOG engages with and, ultimately, its effects on cell viability. Here we designed and characterised a series of MOG analogues with the aims of improving compound stability and exploring the functional requirements for interaction with MCT2, a relatively understudied member of the SLC16 family. We report MOG analogues that maintain ability to enter cells via MCT2, and identify compounds that do not inhibit glutaminolysis or cause cytotoxicity but can still inhibit PHDs. We use these analogues to show that, under our experimental conditions, glutaminolysis-induced activation of mTORC1 can be uncoupled from PHD activity. Therefore, these new compounds can help deconvolute cellular effects that result from the polypharmacological action of NOG.
Optogenetic manipulation of cell migration with high spatiotemporal resolution using lattice lightsheet microscopy
Authors: Tang Wei-Chun , Liu Yen-Ting , Yeh Cheng-Han , Lu Chieh-Han , Tu Chiao-Hui , Lin Yi-Ling , Lin Yu-Chun , Hsu Tsui-Ling , Gao Liang , Chang Shu-Wei , Chen Peilin , Chen Bi-Chang 
Published: August 2022

AbstractLattice lightsheet microscopy (LLSM) featuring three-dimensional recording is improved to manipulate cellular behavior with subcellular resolution through optogenetic activation (optoLLSM). A position-controllable Bessel beam as a stimulation source is integrated into the LLSM to achieve spatiotemporal photoactivation by changing the spatial light modulator (SLM) patterns. Unlike the point-scanning in a confocal microscope, the lattice beams are capable of wide-field optical sectioning for optogenetic activation along the Bessel beam path.We show that the energy power required for optogenetic activations is lower than 1 nW (or 24 mWcm-2) for time-lapses of CRY2olig clustering proteins, and membrane ruffling can be induced at different locations within a cell with subcellular resolution through light-triggered recruitment of phosphoinositide 3-kinase. Moreover, with the epidermal growth factor receptor (EGFR) fused with CRY2olig, we are able to demonstrate guided cell migration using optogenetic stimulation for up to 6 h, where 463 imaging volumes are collected, without noticeable cellular damages.
Association of statewide stay-at-home orders with utilization of case management and supportive services for veterans experiencing housing insecurity
Authors: Jutkowitz Eric , Halladay Christopher , Tsai Jack , Hooshyar Dina , Cornell Portia Y. , Rudolph James L. 
Published: August 2022

AbstractThe US Department of Housing and Urban Development-Department of Veterans Affairs (VA) Supportive Housing (HUD-VASH) program provides Veterans with a subsidy for rent and case management. In response to the Coronavirus 2019 pandemic, many states enacted stay-at-home orders that may have limited access to case managers. Therefore, we examined the association between statewide stay-at-home orders and utilization of HUD-VASH case management. We linked data on whether a state implemented a statewide stay-at-home order between March 1, 2020 and April 30, 2020 with VA medical records. Analysis time was centered on the date of a state’s stay-at-home order (exposed states). For Veterans in states without a stay-at home-order (unexposed states), we used the average date exposed states implemented an order (March 27, 2020). We used a difference-in-difference design and adjusted linear regression models to compare total, in-person, telephone, and video case management encounters per Veteran in the 60 days after a stay-at-home order relative to the prior year. There was no significant difference in utilization of case management between Veterans who lived in states that did and did not issue a stay-at-home order. Across all states and in the 60 days after the index date relative to the prior year, Veterans had more total, telephone and video, and fewer in-person encounters. Statewide stay-at-home orders did not differentially affect utilization of case management. Virtual case management in HUD-VASH can increase program reach; however, the effect of virtual case management on outcomes such as quality of life and Veteran satisfaction is unknown.
Why trans and not cis? – Molecular dynamics and DFT study on selective separation of dihaloethene isomers using perethylated pillar[5]arene
Authors: Priscilla A Shanthini , Peters Silda , Ebenezer Cheriyan , Varathan Elumalai , Vijay Solomon Rajadurai 
Published: August 2022

Selective encapsulation of trans dihaloethene over cis dihaloethene using perethylated pillar[5]arene through computational investigation.
Determining the dust environment of an unknown comet for a spacecraft flyby: The case of ESA’s Comet Interceptor mission
Authors: Marschall Raphael , Zakharov Vladimir , Tubiana Cecilia , Kelley Michael S. P. , van Damme Carlos Corral , Snodgrass Colin , Jones Geraint H. , Ivanovski Stavro L. , Postberg Frank , Della Corte Vincenzo , Vincent Jean-Baptiste , Muñoz Olga , La Forgia Fiorangela , Levasseur-Regourd Anny-Chantal ,   the Comet Interceptor Team
Published: August 2022

Context.An assessment of the dust environment of a comet is needed for data analysis and planning spacecraft missions, such as ESA’s Comet Interceptor (CI) mission. The distinctive feature of CI is that the target object will be defined shortly before (or even after) launch; as a result, the properties of the nucleus and dust environment are poorly constrained, and therefore make the assessment of the dust environment challenging.Aims.The main goal of the work is to provide realistic estimations of a dust environment based on very general parameters of possible target objects.Methods.Contemporary numerical models of a dusty-gas coma were used to obtain spatial distribution of dust for a given set of parameters. By varying parameters within a range of possible values, we obtained an ensemble of possible dust distributions. Then, this ensemble was statistically evaluated in order to define the most probable cases and hence reduce the dispersion. This ensemble can not only be used to estimate the likely dust abundance along a flyby trajectory of a spacecraft, for example, but also to quantify the associated uncertainty.Results.We present a methodology of the dust environment assessment for the case when the target comet is not known beforehand (or when its parameters are known with large uncertainty). We provide an assessment of dust environment for the CI mission. We find that the lack of knowledge of any particular comet results in very large uncertainties (~3 orders of magnitude) for the dust densities within the coma. The most sensitive parameters affecting the dust densities are the dust size distribution, the dust production rate, and coma brightness, often quantified by Afρ. Further, the conversion of a coma’s brightness (Afρ) to a dust production rate is poorly constrained. The dust production rate can only be estimated down to an uncertainty of ~0.5 orders of magnitude if the dust size distribution is known in addition to the Afρ.Conclusions.To accurately predict the dust environment of a poorly known comet, a statistical approach needs to be taken to properly reflect the uncertainties. This can be done by calculating an ensemble of comae covering all possible combinations within parameter space as shown in this work.
Bedürfnisse onkologisch erkrankter Kinder: Psychometrische Überprüfung des Erhebungsinstruments „KiWuF-PädOnk“ und erste Ergebnisse
Authors: Böcherer Sarah Magdalena , Burger Thorsten , Schepper Florian , Farin-Glattacker Erik 
Published: August 2022

ZusammenfassungIn der vorliegenden Querschnittstudie wurde ein neu konzipierter Bedürfnisfragebogen für 8- bis 13-jährige Krebspatienten psychometrisch überprüft (N = 117). Auf der Grundlage einer explorativen Faktorenanalyse wurden 4 Skalen mit insgesamt 19 Items gebildet. Die interne Konsistenz des Fragebogens ist zufriedenstellend. Die Teilnehmenden äußerten ein starkes Bedürfnis nach sozialer Teilhabe, Sicherheit und Kontrollerleben sowie nach Normalität. Der KiWuF-PädOnk liefert Informationen zu Bedürfnissen aus Patientensicht und fördert somit eine individuumszentrierte psychosoziale Versorgung.
Langzeitergebnisse der Extensor-indicis-Transposition bei Ruptur der
Extensor pollicis longus Sehne nach kindlicher Unterarmfraktur
Authors: Moeller Richard-Tobias , Mentzel Martin , Vergote Daniel , Bauknecht Simon 
Published: August 2022

Zusammenfassung
Hintergrund Eine seltene, aber typische perioperative Komplikation bei der
operativen Versorgung von kindlichen Unterarmfrakturen ist die Verletzung der
Extensor pollicis longus (EPL) Sehne. Im vorliegenden Artikel werden die
Langzeitergebnisse nach Rekonstruktion der EPL-Sehne mit Transposition der
Extensor-indicis-Sehne (EI-Sehne) bei Kindern und Jugendlichen nach operativ
versorgter Unterarmfraktur vorgestellt.
Patienten und Methoden Im Zeitraum von 15 Jahren wurden 22 Kinder bis zum
Alter von 16 Jahren mit einer EI-Transposition analog zur Versorgung bei
Erwachsenen behandelt. In einer Nachuntersuchung wurden die
Bewegungsumfänge der Finger- und Daumengelenke, die Retropulsion des
Daumens und Zeigefingers, die Abduktion und Opposition untersucht.
Zusätzlich wurde die Handspanne und die Kraft im Grob-,
Schlüssel- und Spitzgriff gemessen. Das subjektive Beschwerdebild wurde
befragt und der DASH-Score erhoben.
Ergebnisse Die Ruptur der EPL-Sehne ist mit 1% aller operativ
versorgten kindlichen Unterarmfrakturen eine seltene Komplikation. 15 Patienten
mit einem Durchschnittsalter von 10,9 Jahren konnten durchschnittlich 66,5
Monate nach Transposition der EI-Sehne nachuntersucht werden. Signifikante
messtechnische Unterschiede fanden sich in der reduzierten Beweglichkeit des
Daumengrundgelenkes, der isolierten Streckfähigkeit des Zeigefingers,
einer reduzierten Spanne zwischen Daumen und Zeigefinger in der Palmarduktion
sowie eine reduzierte Kraft im Spitzgriff. Subjektiv wurden die
Seitendifferenzen von den Patienten und ihren Eltern im Alltag nicht
bemerkt.
Schlussfolgerung Die Transposition der EI-Sehne zur Rekonstruktion einer
rupturierten EPL-Sehne als seltene Komplikation nach kindlicher Unterarmfraktur
führt langfristig zwar zu einer messtechnisch signifikanten Reduktion
der Zeigefingerbeweglichkeit auf der betroffenen Seite, jedoch ohne subjektive
Einschränkungen der Kinder.
Recent Advances for Chiral Sulfoxides in Asymmetric Catalysis
Authors: Dong Zhi-Bing , Yang Meng-Meng , Wang Si 
Published: August 2022

AbstractChiral sulfoxide is considered to be an ideal candidate ligand for transition-metal-catalyzed asymmetric reactions due to its ease of synthesis, stability, and exceptional S-stereological orientation control. This paper reviews the different types of asymmetrical reactions with chiral sulfoxide ligands in recent years, as well as a discussion of efficient methods for the preparation of some enantiomerically pure sulfoxides.1	Introduction2	Chiral Sulfoxides as Ligands in Metal-Catalyzed Asymmetric Catalysis3	Synthesis of Chiral Sulfoxides4	Conclusions