bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barrier identification and implementation strategy integration in the guidelines of optimal postpartum care for advanced maternal age in China: a study based on the CFIR-ERIC implementation strategy matching tool
Authors: Deng Bo , Yang Kezhou , Wang Yan , Li Yan , Hu Yali , Liu Ning 
Published: November 2022

Abstract
Background
Due to advanced maternal age facing great risks of fertility, such as gestational hypertension, postpartum haemorrhage, miscarriage, etc., we must attach importance to postpartum care. Guidelines for optimal postpartum care are available. It is of great significance to identify potential barriers and tailor practical implementation strategies before implementing the guidelines. The purpose of this study aimed to use the implementation science methods to develop implementation strategies that could promote the implementation of postpartum care guidelines in clinical practice.
Methods
Purposive sampling was used to recruit 13 obstetric nurses who had previously participated in the implementation of the postnatal care guidelines for semi-structured interviews. The Consolidated Framework for Implementation Research (CFIR) of 39 structures guided us in collecting and analysing interview data to identify barriers. We then determined implementation strategies by using Consolidated Framework for Implementation Research–Expert Recommendations for Implementing Change (CFIR-ERIC) Implementation Strategy Matching Tool and taking into account the local context.
Results
The interview content was categorized, coded, and explained, and finally ten barriers were identified, including Evidence Strength & Quality, Complexity, Patient Needs & Resources, Compatibility, Structural Characteristics, Access to knowledge and information, Learning Climate, Knowledge & Beliefs about the Intervention, Self-efficacy, Key Stakeholders. Under the guidance of the CFIR-ERIC Implementation Strategy Matching Tool, some implementation strategies were developed to address these barriers for clinical nurses and the needs of patients and their families, which include conducting educational meetings, developing educational materials for nurses and patients, obtaining feedback from women and their families to meet their needs, rationalize implementation time, improve clinical assessment tools, streamline guideline-based workflows.
Conclusion
We can apply the CFIR-ERIC Implementation Strategy Matching Tool to select the best implementation strategies to address the barriers based on CFIR and promote the implementation of optimal postpartum care guidelines for advanced maternal age.
The quandary of detecting the signature of climate change in Antarctica
Authors: Casado Mathieu , Hébert Raphaël , Faranda Davide , Landais Amaelle 
Published: November 2022

Abstract
The current global warming driven by human activities has been accentuated in Polar Regions due to the polar amplification, resulting in large releases of ice that have impacts on circulation and sea level at the global scale. In the Arctic, the temperature has increased at three times the global rate, and lead to significant melt of the Greenland ice sheet and sea ice decline. Yet, for Antarctica, the impact of warming is still poorly constrained given the lack of instrumental data and the large decadal climate variability. Using a compilation of 78 ice core records, we provide a high-resolution reconstruction of past temperatures over the last 1000 years for seven regions of Antarctica and direct evidence of Antarctic polar amplification at regional and continental scales. We also show that both the natural and forced variability are not captured by pseudo-proxy experiments using the CMIP5 and 6 ensembles. This that the feedback loops causing the polar amplification are not properly taken into account, leading to an underestimation of the magnitude of anthropogenic warming and its consequences in Antarctica.
Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers collateral sensitivity to ALK inhibitors in high-risk neuroblastoma
Authors: Pucci Perla , Lee Liam , Han Miaojun , Matthews Jamie , Jahangiri Leila , Manners Eleanor , Sorby-Adams Annabel , Schlederer Michaela , Kaggie Joshua , Trigg Ricky , Prokoph Nina , Ducray Stephen , Merkel Olaf , Rifatbegovic Firkret , Luo Ji , Taschner-Mandl Sabine , Kenner Lukas , Burke Gladstone , Turner Suzanne 
Published: November 2022

Abstract

Targeting Anaplastic lymphoma kinase (ALK) is a promising therapeutic strategy for aberrant ALK-expressing malignancies including neuroblastoma (NB), but resistance to ALK inhibitors (ALK TKI) is a distinct possibility necessitating drug combination therapeutic approaches. Using high-throughput, genome-wide CRISPR-Cas9 knockout screens, we identify miR-1304-5p loss as a desensitizer to ALK TKIs in aberrant ALK-expressing NB; inhibition of miR-1304-5p decreased, while mimics increased the sensitivity of NB cells to ALK TKIs. We show that miR-1304-5p targets NRAS, decreasing cell viability via induction of apoptosis. It follows that the farnesyltransferase inhibitor (FTI) lonafarnib in addition to ALK TKIs act synergistically in NB, inducing apoptosis both in vitro and in vivo. In particular, on combined treatment of NB patient derived xenografts with an FTI and an ALK TKI complete regression of tumour growth was observed although tumours rapidly regrew on cessation of therapy. Overall, our data suggests that combined use of ALK TKIs and FTIs, constitutes a therapeutic approach to treat high risk NB although prolonged therapy is likely required to prevent relapse, rendering high-risk NB a chronic rather than a lethal disease.
High rates of alkaline phosphatase activity in an equatorial coral reef ecosystem unrelated to seasonal nutrient dynamics
Authors: Nichols Robert S. , Moynihan Molly A. , Martin Patrick 
Published: November 2022

Abstract
Coral reef productivity depends on fast nutrient cycling, mediated largely by enzymatic breakdown of organic matter. Alkaline phosphatases hydrolyse phosphomonoesters and are one of the key enzymes involved in marine phosphorus cycling. They are expressed by a plethora of marine organisms including both planktonic microbes and metazoans such as corals, often in response to phosphate limitation, and are potentially important for coral P nutrition and reef biogeochemical cycling. However, most alkaline phosphatase activity (APA) data are from open-ocean environments, and the rates and drivers of APA in coastal waters are not well understood. Here, we measured APA both in the water column and associated with three coral species at reefs in Singapore, where the monsoonal ocean current reversal creates strong seasonal changes in dissolved nutrient availability. Water column APA was consistently high, averaging 9 ± 10 nmol l-1 h-1, but was not correlated with dissolved phosphate or other biogeochemical parameters. Experimental phosphate addition did not reduce seawater APA but addition of labile organic carbon did increase seawater APA, indicating that the increase in APA was driven by heterotrophic activity rather than phosphate stress. Coral APA ranged from 12–163 µmol m-2 h-1 depending on species and was equivalent to the APA in several meters of overlying water. While most coral APA was associated with the coral holobiont rather than the coral mucus, corals released 12 – 55 µmol h-1 per m2 of mucus-associated APA into the water column, which is potentially significant for water column DOP cycling.
Therapeutic Effect of Combined Therapy of Tui-na and Oral Chinese Medicine on Osteoarthritis of Knee – a Randomized Controlled Trial
Authors: Chan Kin Ho , Ching Jessica YL , Chan Kam Leung , Lau Hoi Yi , Chu Ka Man , Chan Kenny , Pang Hon Fai , Wong Lok Chi , Chia Chon Pin , Song Tianhe , Leung Sin Bond , Ng Bacon Fung Leung , Lin Zhixiu 
Published: November 2022

Abstract
Background

Knee osteoarthritis (KOA) is a common degenerative joint condition that causes disability and pain in the elderly population. The prevalence of KOA among persons aged 63 or above is approximately 30%. Previous studies have reported the positive effect of Tui-na treatment and the Chinese herbal formula Du-Huo-Ji-Sheng Decoction (DHJSD) for KOA treatment. However, the therapeutic effects of the combination of these two methods are unknown. The current study aims to evaluate the therapeutic effect of the combined therapy of Tui-na and oral administration of DHJSD on KOA using a randomized controlled design.

Methods

We conducted a prospective, randomized, wait-list controlled clinical trial. Seventy study subjects with KOA were randomly assigned to the treatment and wait-list control groups in a 1:1 ratio. Both the treatment and wait-list control groups received eight sessions of Tui-na manipulation for 4 weeks. The DHJSD were given to the study subjects in the treatment group, but not the wait-list group. Outcomes were assessed using the WOMAC score and EQ-5D-5L, a health-related quality of life with 5-level EQ-5D version.

Results

The analysis of WOMAC scores and EQ-5D-5L in both groups showed statistically significant improvement with time. The mean WOMAC Pain subscale score was significantly lower in the treatment group than in the wait-list control group at week 8 follow up (P = 0.048). The mean WOMAC Stiffness subscale score was significantly lower in the treatment group than in the wait-list control group at week 2 and week 8 follow up (P = 0.035 and 0.008). The mean EQ-5D index value was significantly improved in the treatment group than in the wait-list control group at week 2 (P = 0.022). No significant adverse effects were found during the trial.

Conclusion

Combined Tui-na and the herbal medication were effective in relieving pain and improving stiffness as well as quality of life (QOL) in patients with KOA. The combined treatment was generally safe and well tolerated.

Trial registration

The study was registered at the ClinicalTrials.gov (website: https://clinicaltrials.gov/ct2/show/NCT04492670, registry number: NCT04492670), registered on 30 July 2020.
Prevalence of depression and anxiety among elderly primary care patients in Palestine
Authors: Maraqa Bessan , Nazzal Zaher , alutt barlant , rishmawi ekram , hamshari suha 
Published: November 2022

Abstract
Background: Depression and anxiety are common mental health disorders among the elderly worldwide. In this study, we estimated the prevalence of depression and anxiety and related risk factor among elderly attending PHC centers in Palestine.
Methods: A cross-sectional study was conducted on a sample size of 380 participants aged ≥60 attending PHC centers in West Bank, using an interviewer-administered questionnaire. We used the Geriatric Depression Scale-15 and the Geriatric Anxiety Scale to screen for depression and anxiety, respectively.We analyzed data using descriptive and analytical statistics and employed logistic regression model to identify predictors of depression and anxiety.
Results: The prevalence of depression and anxiety was 41.1% and 39.2%, respectively. Eldely people living in rural areas (aOR 2.6, 95%CI: 1.7-4.2), uneducated (aOR 2.9, 95%CI: 1.4-6.1), and without monthly income (aOR 3.4, 95%CI: 1.5-7.6) were more likely to have depression. On the other hand, anxiety is independently assosciated with living in rural areas (aOR 1.9, 95%CI: 1.2-3.0) and having non-communicable diseases (aOR 2.0, 95%CI: 1.1-3.5).
Conclusion: Depression and anxiety are common in Palestine, a developing country with a lack of elderly-related services. This should be emphasized at the national and regional levels where geriatric health care services are scarce. Such information is required by policymakers and external funding agencies in order to develop future agendas
Experimental study on the relationship between the strength of altered rocks and the short wave-length infrared spectral curve
Authors: Pan Xuwei , Jiang Tong , Pan Pingping , Jia Yanchang , Zhang Shuo 
Published: November 2022

AbstractAltered rocks widely exist in rock mass engineering. Alteration has an obvious deterioration effect on the physical and mechanical properties of rocks, which may cause engineering geological prob-lems or geological hazards. The main method to obtain the uniaxial compressive strength of altered rocks is indoor uniaxial compression test, which has the reality of long period, high cost, difficult sampling, and limited transportation. In this paper, the uniaxial compression test and short wavelength infrared spectral test analysis are performed on the altered rocks of a hydropower station in Southeast China to study the relationship between the strength and the short wavelength infrared spectral curve of altered rocks. The results show that, there is a correlation between the number of absorption peaks of short wavelength infrared spectral curve and the uniaxial compressive strength of altered rocks. In the wavelength ranges of 1880–1950 nm and 2170–2230 nm, the uniaxial compressive strength of altered rocks with two absorption peaks in the short wavelength infrared spectral curves are generally higher than 150 MPa. In the wavelength ranges of 1380–1430 nm, 1880–1950 nm, and 2170–2230 nm, the uniaxial compressive strength of altered rocks with three absorption peaks in the short wavelength infrared spectral curves are generally lower than 100 MPa. In the wavelength ranges of 1380–1430 nm, 1630–1660 nm, 1880–1950 nm, 2170–2230 nm, 2230–2380 nm, the uniaxial compressive strength of altered rocks with four absorption peaks in the short wavelength infrared spectral curves are generally between 100–150 MPa. This research will provide a new method for rapid evaluation of strength of altered rocks in the field.
Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive protection across divergent subgroups
Authors: Hutchinson Geoffrey , Abiona Olubukola , Ziwawo Cynthia , Werner Anne , Ellis Daniel , Tsybovsky Yaroslav , Leist Sarah , Palandjian Charis , West Ande , Fritch Ethan , Wang Niangshuang , Wrapp Daniel , Boyoglu-Barnum Seyhan , Ueda George , Baker David , Kanekiyo Masaru , McLellan Jason , Baric Ralph , King Neil , Graham Barney , Corbett Kizzmekia 
Published: November 2022

Abstract
Multivalent antigen display is a fast-growing area of interest towards broadly protective vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer antibody-mediated immunity against divergent strains of notably mutable viruses. In coronaviruses, this work is predominantly aimed at targeting conserved epitopes of the receptor-binding domain. However, targeting other conserved non-RBD epitopes could further limit the potential for antigenic escape. To further explore new potential targets, we engineered protein nanoparticles displaying CoV_S-2P trimers derived from MERS-CoV, SARS-CoV-1, SARS-CoV-2, hCoV-HKU1, and hCoV-OC43 and assessed their immunogenicity in mice. Monotypic SARS-1_S-2P nanoparticles elicited cross-neutralizing antibodies against MERS_S and protected against MERS-CoV challenge. MERS and SARS-I53_dn5 nanoparticles elicited S1-focused antibodies, revealing a conserved site on the NTD. Moreover, mosaic nanoparticles co-displaying distinct CoV_S-2P trimers elicited antibody responses to distant cross-group antigens while protecting against MERS challenge despite diminished valency of MERS_S-2P. Our findings will inform further efforts towards the development of pan-coronavirus vaccines.
FNAOSiPPEA: an effective magnetite almond shell-based nano catalyst for the synthesis of dihydropyrano[3,2-c]chromene and tetrahydrobenzo[b]pyran
Authors: Mallah Dina , Mirjalili Bi Bi Fatemeh , Bamoniri Abdolhamid 
Published: November 2022

Abstract
This paper deals with the preparation of magnetite biopolymer-based Brønsted base nano-catalyst from nano-almond (Prunus dulcis) shell. This magnetite biopolymer-based nano-catalyst was obtained through a simple process based on the core-shelling of nano-almond shell and Fe3O4 NPs and then the immobilization of 3-chloropropyltrimethoxysilane as linker and 2-aminoethylpiperazine as a basic section. Structural and morphological analyzes of this magnetite biopolymer-based nano-catalyst were done. The performance of the synthesized Fe3O4@nano-almondshell@OSi(CH2)3/2-(1-piperazinyl)ethylamine as a novel magnetite biopolymer-based nano-catalyst for the synthesis of dihydropyrano[3,2-c]chromene and tetrahydrobenzo[b]pyran was investigated and showed excellent efficiency.
Study on the failure law of surrounding rock in inclined coal seam with gob side entry
Authors: Wu Hao , Li Qingfeng , Zhu Chuanqu , He Liao 
Published: November 2022

Abstract
Aiming at the problem of stability control of surrounding rock in the process of upward mining of inclined coal seam gob-side entry retaining, the gob-side entry retaining of 5449 working face in Beipingdong coal mine is taken as the research background. Based on the study of theoretical model of gob-side entry retaining, the law of overburden movement and surrounding rock deformation in the process of gob-side entry retaining is obtained through similar simulation experiment and numerical simulation analysis, and the optimal optimization scheme of supporting structure is put forward. The main research results are as follows : in the process of coal seam mining, the center of gravity of the overlying strata on the whole working face will shift to the side of the goaf, and the supporting structure composed of roadside filling body and bolt effectively inhibits the deformation of the roadway, in which the roadside filling body plays a key role ; the top bolt bears greater stress than the side bolt in the process of mining, so the top bolt mainly maintains the stability of the roadway, and the side bolt plays the role of strengthening the side and preventing the extrusion. The width of the roadside filling body should be about 2.5m, and the plastic failure range can be well controlled under this width.
S100B does not predict delirium in emergency department patients: a prospective cohort study
Authors: de Alencar Júlio César Garcia , Garcez Flávia Barreto , Pinto Agnes Araujo Sardinha , Silva Lucas Oliveira Junqueira e , Soler Lucas de Moraes , Fernandez Shirley Steffany Muñoz , Vaisberg Victor Van , Gomez Luz Marina Gomez , Ribeiro Sandra Maria Lima , Avelino-Silva Thiago Junqueira , Souza Heraldo Possolo 
Published: November 2022

Abstract
Background

Delirium is a common, life-threatening, and often preventable neuropsychiatric emergency mostly characterized by a disturbance in attention and awareness. Systemic insult and inflammation causing blood-brain-barrier (BBB) damage and glial and neuronal activation leading to more inflammation and cell death is the most accepted theory behind delirium's pathophysiology. This study aims to evaluate the relationship between neuronal damage biomarkers and delirium in acutely ill elderly patients admitted in the Emergency Department (ED).

Methods

We performed a prospective cohort study which analyzed plasma S100B levels at admission in elderly patients. Our primary outcome was delirium diagnosis. Secondary outcomes were association between S100B, NSE and Tau protein and delirium diagnosis and patients’ outcomes (admissions to intensive care, length of hospital stay, and in-hospital mortality).

Results

We analyzed 194 patients, and 46 (24%) developed delirium, 25 on admission and 21 during hospital stay. Median of S100B at admission in patients who developed delirium was 0.16 and median was 0.16 in patients who didn’t develop delirium (p: 0.69)

Conclusions

Levels S100B at the time of ED admission did not predict delirium in elderly patients admitted in the ED.
Trial registration: The study was approved by the local institutional review board (CAPPESq, no. 77169716.2.0000.0068, October 11, 2017) and registered in Brazilian Clinical Trials Registry (ReBEC, no. RBR-233bct).
Two Azores shipwrecks and insect biological invasions during the Age of Discovery
Authors: Panagiotakopulu Eva , Garcia Ana Catarina 
Published: November 2022

Abstract
Insect faunas from a Spanish and a Dutch shipwreck, Angra D and Angra C, recovered from a bay on Terceira island, Angra do Heroísmo, in the Azores, and dated to c. 1650 CE, provide information about the onboard ecology of seventeenth century shipping vessels and the role of these ships and of contemporary maritime routes in biological invasions. In addition to evidence for foul conditions, there is evidence for similar insect faunas on both these ships. The assemblages include the earliest records of the now cosmopolitan synanthropic scuttle fly Dohrniphora cornuta (Bigot) which was probably introduced through trade from southeast Asia to Europe. The presence of the American cockroach, Periplaneta americana (L.) from Angra D, in the context of other sixteenth and seventeenth century records from shipwrecks, gives information about its spread to North America and Europe through transatlantic and transpacific trade, hitching a ride with traded commodities. The insect data point to the importance of introduced taxa on traded commodities and ballast, transported from port to port, and the role of ports of call like Angra in the Azores, as hot spots for biological invasions.
Neoadjuvant Chemotherapy for Locally Advanced Oral Squamous Cell Carcinoma: A Single Center Study
Authors: Shen-sui Li , weili Wang , Xu-dong Tian , Longjiang Li , Ma Hong 
Published: November 2022

Abstract
Objective:Aimed to evaluate the effect and response from the adjuvant chemotherapy for locally advanced oral squamous cell carcinoma.
Methods: Retrospectively collected 46 patients with local late oral squamous cell carcinoma admitted from 2017 to 2021. The patients were treated with TPF induction chemotherapy. All patients completed at least 2 cycle of TPF (PF) regimen (75 mg / m2 of docetaxel on day 1 + 75 mg / M2 of cisplatin on day 1 + 750 mg / m2 of 5-fluorouracil on days 1 ~ 5, one cycle every 21 days), The primary end-points were overall response rate, safety of therapy and overall survival were evaluated.
Results: After two cycles of TPF treatment, patients continued receiving surgery followed by radiotherapy or chemotherapy, include 5 patients were received PF. The complete remission rate was 6.25% (2/32), and the objective remission rate was 71.88% (23/32). Most of the adverse factors of chemotherapy response are alleviated. The median follow-up time was 26 months, and the median OS was 25.51 ± 3.81 months.
Conclusion: Neoadjuvant chemotherapy, such as TPF or PF, plays an important role in the comprehensive treatment of advanced OSCC and postoperative assessments of white blood cell can provide high-quality prognostic information.
Encrypted Malware Detection Methodology without Decryption using Deep Learning based Approaches
Authors: Singh Abhay Pratap 
Published: November 2022

Abstract

The proportion of encrypted web traffic is rapidly increasing. The widespread use of encrypted traffic on the Internet provides safe and secure communication between users and servers. However, cybercriminals are also employing encrypted traffic to conceal their malicious activities. Malware detection in encrypted traffic is an arduous task for security professionals due to the complex nature of encrypted traffic on the web. Traditional approaches need to decrypt the content of network traffic, check it for threats, re-encrypt the network traffic content, and send it to the server. This solution compromises the integrity of encryption and the user’s privacy and safety. DL is currently the most effective AI technology that can reduce the manual determination of feature sets to improve classification accuracy. This paper proposes a methodology by using DL algorithms for malware detection in encrypted traffic without decryption. With this architecture, the user’s privacy is maintained, and the efficiency of detecting threats in encrypted traffic is enhanced. Three deep learning techniques, namely, multilayer perceptron (MLP), 1D convolutional neural network (1-D CNN), and long short-term memory (LSTM), are tested on the CTU-13 malware dataset, which comprises flow based features of network traffic. Experimental results show that MLP based approach outperforms 1-D CNN, LSTM, and other existing approaches.