bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Follow-Up for Adolescents With Depression in Primary Care
Authors: Garbutt Jane , Dodd Sherry , Rook Shannon , Graham Sharon , Wang Ruoyun , Sterkel Randall , Plax Katie 
Published: May 2022

BACKGROUND
Few adolescents with depression receive treatment in accordance with national guidelines. This quality improvement project took place in 11 primary care practices with the primary aim of increasing the percentage of teens with depression who received follow-up care within 6 weeks of diagnosis and within 3 months, once stable.

METHODS
The primary strategy was external practice facilitation for 12 months. The change process used goal setting and plan-do-study-act cycles to identify and implement change ideas. A preanalysis and postanalysis was completed to evaluate process change, provider confidence, and patient improvement.

RESULTS
Randomly selected samples of 199 and 217 charts of teens newly diagnosed with depression were reviewed before and after the intervention, respectively. Chart data for these measurements was provided by 10 and 9 practices, respectively. The percentage of patients with follow-up care within 6 weeks after diagnosis increased from 40% to 81% (P &lt; .001), the percentage with a follow-up visit within 3 months once stable increased from 30% to 60% (P &lt; .001), and the percentage in remission at 6 months increased from 7% to 21% (P &lt; .001). Providers reported increased confidence to diagnose and manage depression, assess severity, provide pharmacotherapy, and educate families.

CONCLUSIONS
Practices improved follow-up care for teens with depression. In addition, providers experienced an improvement in their confidence to diagnose and manage depression. Working with a facilitator, each practice implemented standardized systems to provide effective care in the medical home, increase providers’ confidence to address this common problem, and improve patient outcomes.
Pediatric ICU Admissions After Adolescent Suicide Attempts During the Pandemic
Authors: Bruns Nora , Willemsen Lea , Stang Andreas , Kowall Bernd , Holtkamp Katharina , Kamp Oliver , Dudda Marcel , Hey Florian , Hoffmann Florian , Blankenburg Judith , Eifinger Frank , Fuchs Hans , Haase Roland , Baier Jan , Andrée Clemens , Heldmann Michael , Maldera Vanessa , Potratz Jenny , Kurz Daniel , Mand Nadine , Doerfel Claus , Rothoeft Tobias , Schultz Michel , Ohlert Manuel , Silkenbäumer Katrin , Boesing Thomas , Indraswari Fithri , Niemann Frank , Jahn Peter , Merker Michael , Braun Nicole , Nunez Francisco Brevis , Engler Matthias , Heimann Konrad , Brasche Milian , Wolf Gerhard , Freymann Holger , Dercks Martin , Hoppenz Marc , Felderhoff-Müser Ursula , Dohna-Schwake Christian 
Published: May 2022

BACKGROUND AND OBJECTIVES
The worldwide severe acute respiratory syndrome coronavirus 2 pandemic challenges adolescents’ mental health. In this study, we aim to compare the number of pediatric ICU (PICU) admissions after suicide attempts during the first German lockdown and one year later during a second, prolonged lockdown with prepandemic years.

METHODS
A retrospective multicenter study was conducted among 27 German PICUs. Cases &lt;18 years admitted to the PICU because of accidents or injuries between March 16 and May 31 of 2017 to 2021 were identified based on International Classification of Diseases, 10th Revision codes (German modification) and patient data entered into a database. This study is a subset analysis on suicide attempts in adolescents aged 12 to 17.9 years. The Federal Statistics Office was queried for data on fatal suicides, which were available only for 2020 in adolescents aged 10 to 17.9 years.

RESULTS
Total admissions and suicide attempts declined during the first lockdown in 2020 (standardized morbidity ratio 0.74 (95% confidence interval; 0.58–0.92) and 0.69 (0.43–1.04), respectively) and increased in 2021 (standardized morbidity ratio 2.14 [1.86–2.45] and 2.84 [2.29–3.49], respectively). Fatal suicide rates remained stable between 2017 to 2019 and 2020 (1.57 vs 1.48 per 100 000 adolescent years) with monthly numbers showing no clear trend during the course of 2020.

CONCLUSIONS
This study shows a strong increase in serious suicide attempts among adolescents during the course of the pandemic in Germany. More research is needed to understand the relation between pandemic prevention measures and suicidal ideation to help implement mental health support for adolescents.
Critical reflections on ethnographic data collection in the highly gendered environment of male football
Authors: Wolfers-Pommerenke Solvejg 
Published: May 2022

This article critically reflects on the methodological implications of indexing gender and sexuality by research participants when conducting ethnographic fieldwork in explicitly gendered contexts, particularly where notions of hegemonic masculinity are prevalent. Research suggests a number of potential challenges for female researchers, such as being patronised and subjected to sexist attitudes, among others. In order to gain a greater understanding of these methodological challenges, this study draws on over 60 hours of audio-recorded and observed interactions among male professional and elite football (‘soccer’ in US English) players and coaches before, during and after football matches and trainings. The main focus is the kinds of gendered and sexualised identities participants regularly assign to the female researcher in discursive interaction. This shows that, in ethnographic research projects, the construction of gender and sexual identities is potentially always relevant to data collection and research outcome. In diesem Artikel werden die methodischen Implikationen der Indizierung von Gender und Sexualität durch Forschungsteilnehmer in ethnografischer Feldforschung in explizit gegenderten Kontexten, wo Vorstellungen von hegemonialer Männlichkeit vorherrschen, kritisch reflektiert. Die Forschung deutet diesbezüglich auf eine Reihe potenzieller Herausforderungen für weibliche Forscherinnen hin, unter anderem, Bevormundung und sexistischer Umgang. Um diese methodischen Herausforderungen besser zu verstehen, stützt sich diese Studie auf über 60 Stunden Audioaufzeichnungen und Beobachtungen von Interaktionen zwischen männlichen Profi- und Elite-Fußballspielern und Trainern vor, während und nach Fußballspielen und Trainingseinheiten. Es geht in der Studie vor allem darum, welche Art von gegenderten und sexualisierten Identitäten die männlichen Teilnehmer der weiblichen Forscherin regelmäßig in diskursiven Interaktionen zuordnen. Dies zeigt, dass in ethnografischen Forschungsprojekten die Konstruktion gegenderter und sexualisierter Identitäten potenziell immer relevant für die Datenerhebung und das Forschungsergebnis ist.
Expanding therapeutic opportunities for progressive uterine cancer: clinical experience
Authors: Kedrova A. G. , Krasilnikov S. E. , Berishvili A. I. , Zvezdkina E. A. 
Published: May 2022

The incidence of uterine cancer in Russia increased by 28.8 % over the last 10 years. This trend is partly associated with an increasing prevalence of overweight and aging of the female population. Despite the fact that uterine cancer is limited to the uterine body in 84 % of cases, searching for new treatment regimens for patients with progressive disease is still relevant because of their poor outcomes of chemotherapy and high mortality among patients with stage III– IV cancer.The aim of this study was to present our own view on the effectiveness of lenvatinib + pembrolizumab in patients with advanced or recurrent endometrial cancer on the basis of international and own experience.The international experience with lenvatinib + pembrolizumab for advanced endometrial cancer without high microsatellite instability or impairments of DNA repair mechanisms after disease progression following previous systemic therapy showed their efficacy (38.3 %), while the effect lasting more than 6 months was observed in 69 % of cases. We report two cases of progressive uterine cancer in patients who developed complete clinical remission and demonstrated good tolerability of the therapy.
Causes of resistance to PARP inhibitors and ways to overcome it. Case report of aggressive <i>BRCA</i>-related breast cancer
Authors: Stukan A. I. , Goryainova A. Yu. , Sharov S. V. , Goncharova O. A. , Khachmamuk Z. K. , Durov V. V. 
Published: May 2022

PARP inhibitors. However, in clinical practice, despite the proven antitumor efficacy of drugs, acquired resistance to PARP inhibitors leads to difficulties in selecting further therapy due unknown resistance mechanisms and absence of algorithm of action. Despite the various mechanisms of resistance to PARP inhibitors, the choice of subsequent combination therapy after the detection of resistance to PARP inhibitors should be based on an understanding of these mechanisms and the existence of heterogeneous metastatic process. At the same time, it is very important to study the molecular and genetic characteristics of the disease at each stage of progression, which will help to identify the cause of resistance and select the optimal treatment strategy. It seems that liquid biopsy of circulating tumor DNA, detection of circulating tumor cells, circulating microRNA or exosomes may be more suitable methods of molecular diagnostics than repeated biopsies. Currently, there are data on the identification of two types of resistance to PARP inhibitors: mechanisms independent and dependent on the BRCA1/2 gene and homologous DNA recombination repair (HRR) mechanisms. Strategies for using combinations of different therapeutic regimens in conjunction with PARP inhibitors are very promising options for preventing treatment resistance in view of the increasing number of patients with similar clinical course of the disease.In the presented clinical case, BRCA1-associated triple-negative breast cancer demonstrates an aggressive clinical course in case of adjuvant chemotherapy absence. Using the example of a clinical case, the effectiveness of therapy with the PARP inhibitor olaparib in disseminated BRCA1-mutated breast cancer, including those with brain metastases, was confirmed. At the same time, against the background of good tolerance and сlinical efficacy especially in the case of brain metastases, the use of the PARP inhibitor olaparib is a worthy alternative to chemotherapeutic regimens. The selection of subsequent therapy after a PARP inhibitor requires a balanced approach, taking into account the possible causes of crossresistance with chemotherapy regimens.
Influence of cane and beet sugar for second fermentation on “fruity” aromas in Auxerrois sparkling wines
Authors: Wilson Andrew , Charnock Hannah , Xu Shufen , Kemp Belinda 
Published: May 2022

Traditional Method sparkling wine production requires a sugar addition to the base wine to initiate the second alcoholic fermentation in bottles. This study aimed to identify differences in “fruity” volatile aroma compounds (VOCs) in Traditional Method sparkling wines produced from the addition of either cane sugar or beet sugar to Auxerrois base wines. Wines underwent a second fermentation in bottles inoculated with IOC 18-2007 yeast and fermented at 15 °C. Standard chemical analysis was carried out on base wines and sparkling wines. The concentrations of fourteen “fruity” volatile aroma compounds representing five classes of compounds were analysed by Headspace-Solid-Phase Micro-Extraction-Gas Chromatography-Mass Spectrometry (HS-SPME-GC-MS). Cane and beet sugars were analysed in de-aromatised wine and distilled water to establish the concentrations of VOCs present in the sugar products prior to addition to wine. Wines were analysed on the day of inoculation and bottling and again after the second fermentation. Beet sugar significantly (Pt < 0.05) increased the concentration of linear fatty acid-derived ethyl esters (ethyl octanoate, ethyl hexanoate, and ethyl butyrate) compared to cane sugar in sparkling wine. These results are attributed to higher concentrations of medium-chain fatty acids found in beet sugar due to the duration of sugar beet storage prior to processing. Recommended future research includes monitoring aroma compounds during ageing on lees, sensory analysis, and an investigation of a wider range of sugar products permitted for use in sparkling wine production.
KONTRIBUSI RELIGIUSITAS TEHADAP RESILIENSI AKADEMIK MAHASISWA SELAMA PEMBELAJARAN DARING
Authors: Ulfa Miladiah Fakhriatul 
Published: May 2022

Latar belakang: Banyaknya kendala dan tantangan yang dihadapi mahasiswa selama kuliah daring, mengharuskan mereka untuk memiliki ketahanan yang tinggi dalam dirinya agar mampu bertahan menghadapi kondisi sulit sehingga diperlukan resiliensi akademik. Religiusitas diyakini sebagai salah satu faktor yang mempengaruhi tingkat resiliensi akademik, di mana religiusitas dapat membantu pencapaian resiliensi mahasiswa. Tujuan: Tujuan dari penelitian ini ialah untuk melihat pengaruh religiusitas terhadap resiliensi akademik mahasiswa selama menjalani pembelajaran daring. Metode: Metode penelitian ini adalah metode kuantitatif dengan teknik sampling jenuh dan menggunakan analisis regresi linear sederhana untuk melihat nilai pengaruh religiusitas terhadap resiliensi akademik mahasiswa. Hasil: Diperoleh bahwa nilai signifikansi adalah 0,000 (p < 0,05) dengan persamaan regresi Y = 40,583 + 0,397X dan nilai R Square senilai 0,358 (35,8%). Kesimpulan: Disimpulkan bahwa terdapat pengaruh signifikan religiusitas terhadap resiliensi akademik. Hal ini berarti religiusitas memiliki dampak yang signifikan dalam menentukan tingkat resiliensi akademik pada mahasiswa selama menjalani pembelajaran daring.
Kata kunci: religiusitas, resiliensi akademik, mahasiswa, daring.
Biomechanical Evaluation of Different Plate Configurations for Midshaft Clavicle Fracture Fixation
Authors: Kitzen Joep , Paulson Kent , Korley Robert , Duffy Paul , Martin C. Ryan , Schneider Prism S. 
Published: May 2022

Background:
Dual-plate constructs have become an increasingly common fixation technique for midshaft clavicle fractures and typically involve the use of mini-fragment plates. The goal of this technique is to reduce plate prominence and implant irritation. However, limited biomechanical data exist for these lower-profile constructs. The study aim was to compare dual mini-fragment orthogonal plating with small-fragment clavicle plates for biomechanical noninferiority and to determine if an optimal plate configuration could be identified using a cadaveric model.

Methods:
Twenty-four cadaveric clavicles were randomized to 1 of 6 groups, stratified by computed tomography-based bone mineral content (BMC): precontoured superior or anterior fixation using a single 3.5-mm Locking Compression Plate (LCP), and 4 different dual-plating constructs utilizing 2.4-mm and 2.7-mm Adaptation plates or LCPs. An inferior butterfly fracture was created. Axial, torsional, and bending (anterior and superior surface loading) stiffnesses were determined through nondestructive cyclic testing, followed by a load-to-failure test in 3-point superior surface bending.

Results:
For axial stiffness, the 2 dual-plate constructs with a superior 2.4-mm and anterior 2.7-mm plate (either Adaptation or LCP) were significantly stiffer than the other 4 constructs (p = 0.021 and p = 0.034). For both superior and anterior bending, the superior 2.4-mm and anterior 2.7-mm plate constructs were significantly stiffer when compared with the 3.5-mm superior plate (p = 0.043). No significant differences were found in torsional stiffness or load to failure between the different constructs.

Conclusions:
Dual plating using mini-fragment plates is biomechanically superior for the fixation of midshaft clavicle fractures when compared with a single, superior, 3.5-mm plate and has biomechanical properties similar to those of a 3.5-mm plate placed anteriorly. With the exception of axial stiffness, no significant differences were found when different dual-plating constructs were compared with each other.

Clinical Relevance:
This study validates the use of dual plating for midshaft clavicle fractures.
Proxy Capacitance-Resistance Modeling for Well Production Forecasts in Case of Well Treatments
Authors: Gubanova Anna , Orlov Denis , Koroteev Dmitry , Shmidt Sergei 
Published: May 2022

Summary
We disclose a new-age field-scale production forecast model that handles complex treatment of wellbores during their life cycle. Predictive production models have been an object of increased interest and research for a long time due to the need for a fast tool for forecasting production rates or choosing an optimal field development scheme. The existing approaches based on the material balance equation have several limitations and are not very applicable for real objects. Full-scale reservoir modeling is relatively slow and requires large computing resources. In this paper, we propose a proxy model based on advanced capacitance-resistance approach. The model predicts multiphase flow rates based on the available historical data of field production and information about well treatments. In addition, it provides preferable transmissibility trends, the presence of sealed or leaking faults, and the degree of dissipation between injector-producer well pairs. The advanced feature of the model is time-dependent weight coefficients, which have not been studied previously. They help in accounting the shut-in and workover periods and can be found during the optimization procedure simultaneously. Another feature is fast calculations due to a vectorized form of the model and application of modern optimization techniques. All these options allow modeling real oil fields with a large number of wells and a complex system of production control.
The case of a repulsive force in an inhomogeneous gravitational field without shedding momentum
Authors: Semikolenov Andrey 
Published: May 2022

Abstract
This paper considers the case of generating a repulsive force that acts on a body in an inhomogeneous gravitational field in the direction opposite to the force of gravitational attraction. This force differs from the known reactive force in that shedding momentum is not required to generate it, that is, it is not necessary, for example, to eject any mass. At the same time, a necessary condition for generating this type of force is the presence of an inhomogeneous gravitational field. Being able to generate force in this fashion is especially relevant for solving problems related to movement in empty space. In a sense, we could dub this force "quasi antigravitational".
Subtyping of obesity and type 2 diabetes using genetic discordance: a phenome-wide comparative analysis
Authors: Coral Daniel , Tajes Juan Fernandez , Tsereteli Neli , Giordano Giuseppe , Pomares-Millan Hugo , Mutie Pascal , Atabaki-Pasdar Naeimeh , Kalamajski Sebastian , Poveda Alaitz , Miller-Fleming Tyne , Zhong Xue , Cox Nancy , Franks Paul 
Published: May 2022

Abstract
Obesity and type 2 diabetes are causally related, yet the underlying mechanisms are poorly defined. We aimed to subclassify obesity into etiological subtypes using a genetic-driven agnostic approach. Genetic instruments for body mass index and type 2 diabetes were classified into profiles that convey highly concordant (48 SNPs) and discordant (19 SNPs) diabetogenic effects. We annotated association signals for these instruments across clinical and molecular phenotypic layers, spanning > 5,000 traits. Using a combination of machine-learning techniques, key differences were identified in fat distribution, liver metabolism, blood pressure, lipids and branched-chain amino-acids, as well as the sulfotransferase HS6ST2 and several bacterial taxa belonging to the Bacteroidetes and Firmicutes phyla. We reproduced the clinical differences with polygenic scores specific to each profile in an independent cohort, which revealed differential cardiovascular mortality by obesity subtype. Mendelian randomization analyses revealed prominent roles of waist-to-hip ratio, concentration and cholesterol content of HDL particles, and blood pressure in the causal processes leading to diabetes in obesity; through these analyses, we prioritized 17 genes from the discordant signature that convey protection against type 2 diabetes in obesity.
Hotel housekeepers and occupational health: experiences and perceived risks
Authors: Chela-Alvarez Xenia , Bulilete Oana , Garcia-Illan Encarna , Vidal-Thomàs MClara , Llobera Joan 
Published: May 2022

Abstract
Background
Hotel housekeepers are an important occupational group within tourism hotel sector; various health problems related to their job have been described, above all musculoskeletal disorders. The objective of this study is to understand the experiences and perceptions of hotel housekeepers and key informants from the Balearic Islands (Spain) regarding occupational health conditions, the strategies employed to mitigate them and the social context in which they occur.
Methods
A qualitative study with a phenomenological approach was carried out. Six focus groups with hotel housekeepers and 10 semi-structured interviews with key informants (including HHs, an executive housekeeper, health professionals and human resources personnel) were conducted. Next, we carried out a thematic analysis.
Results
Hotel housekeepers reported musculoskeletal disorders, anxiety and stress as main occupational health problems; while health professionals interviewed underscored the physical problems. Hotel housekeepers perceived that their work (characterized by being physically demanding and with repetitive movements) caused their health conditions. To solve health issues, HHs (i) used medication, mostly anti-inflammatory agents and painkillers and, to a lesser extent, sedatives and anxiolytics, which allowed them to continue working; (ii) go to health public services –specialist services in winter and general acute care in summer-, that were more positively perceived when HHs were treated by their family doctor; (iii) use personal protective equipment when suffering from specific health problems; (iv) follow ergonomic recommendations –with difficulties due to high work pace and hotel facilities- and (v) perform physical activity. Although HHs stated having all personal protective equipment needed, most reported an occasional use of it due to the high work pace and the discomfort of wearing gloves, mask and goggles. Two contrasting attitudes were identified regarding sick leave: some HHs refused to accept a doctor-prescribed sick leave –due to fear of being fired, sense of responsibility, downplaying their pain...-, while others accepted it –because they could not continue working, they prioritised health before work-.
Conclusion
Our results might contribute to plan improvement strategies to address health problems among hotel housekeepers, to improve the attention received in primary care settings as well as their working conditions.
Analysis of the Relations between Forestry Financial Supports and Forest Crimes
Authors: Sevinç Volkan 
Published: May 2022

Abstract
Forest crimes are among the serious threats destroying forests. To prevent the forest crimes there are various solutions proposed such as fortification of the laws, increasing the penalties, or increasing the public awareness. This article, however, suggests an alternative solution of preventing the forest crimes by investigating the relations between the individual financial supports provided to forest villagers and the rates of various forest crime types in Turkey. The study shows that, when the forest villagers are given financial supports, the levels of illegal logging, illegally expended trees, and illegal pasturage crimes decrease significantly. However, the financial supports do not affect the levels of illegal transfer of the forestry products, illegally expanding the lands into the forests, and illegal occupation of the forest areas crimes.