bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of maternal true combined endodontic‐periodontal lesion on insulin and inflammatory pathway in adult offspring
Authors: Belardi Bianca Elvira , Mattera Maria Sara de Lima Coutinho , Tsosura Thaís Verônica Saori , dos Santos Rodrigo Martins , Cantiga‐Silva Cristiane , Tavares Ângelo Cintra Luciano , Chiba Fernando Yamamoto , Bravo Lara Teschi , Carvalho Nubia Ramos , Carnevali Ana Carolina Nascimento , de Oliveira Renan Akira Fujii , Ervolino Edilson , Matsushita Doris Hissako 
Published: August 2022

AbstractBackgroundMaternal periodontal disease (PED) and apical periodontitis (AP) are associated insulin resistance (IR), increased tumor necrosis factor‐α (TNF‐α) levels, and alterations in insulin signaling (IS) in the gastrocnemius muscle (GM) of adult offspring. TNF‐α stimulates I kappa B kinase (IKK) and c‐Jun N‐terminal protein kinase (JNK), resulting in IS attenuation. However, studies that investigated the maternal true endodontic‐periodontal lesion (EPL) in offspring are scarce, and in this case, the impact could be even higher. This study aimed to evaluate the effects of EPL on the IR, IS, and inflammatory pathways on the offspring GM.MethodsFemale Wistar rats were distributed into control, AP, PED, and EPL groups. After 30 days of oral inflammation induction, rats from all groups were allowed to mate with healthy rats. The body weight of the offspring was assessed from birth to 75 days of age. After 75 days, the following measurements were performed: glycemia, insulinemia, IR, TNF‐α content, and IKKα/β, JNK, pp185 (Tyr), and IRS‐1 (Ser) phosphorylation status in the GM.ResultsMaternal PED and EPL were associated with low birth weights. All maternal oral inflammations promoted IR and IS impairment in the GM and only maternal PED and EPL caused an increase in TNF‐α content and IKKα/β phosphorylation status in the GM of offspring. The offspring of the rats with EPL group showed worsening of metabolic changes when compared with offspring of rats with AP or PED.ConclusionAssociation of maternal AP and PED promoted a more pronounced worsening in the health of the adult offspring.
Factors influencing pregnancy, litter size, and reproductive parameters of invasive wild pigs
Authors: Chinn Sarah M. , Schlichting Peter E. , Smyser Timothy J. , Bowden Courtney F. , Beasley James C. 
Published: August 2022

AbstractReproduction is the most energetically expensive life stage with the demands of productivity representing a balance between physiological requirements and environmental conditions. Wild pigs (Sus scrofa) throughout most of North America are genetic hybrids of feral domestic pigs and wild boar and have the highest reproductive potential of any wild ungulate. The phenology of reproduction, extent of multiple reproductive events per year, how individual and extrinsic factors contribute to variability in productivity, and impact of genetic lineage on these parameters is not well understood in wild pigs. We quantified reproductive parameters in wild pigs relative to a suite of individual and environmental attributes across seasons and multiple years in South Carolina, USA, from March 2017 and May 2020. We hypothesized that individual attributes (mass, age class, number of teats, rump fat, relative genetic association to wild boar vs. domestic pigs) and extrinsic factors (mast availability) would influence probability of pregnancy and fetal litter size. Wild pigs produced offspring throughout all months with peaks in conception corresponding to a seasonal pulse in food availability. The likelihood of pregnancy was influenced by female mass and nutritional condition and was greatest during years with abundant resources. Similarly, litter size increased with female mass and age, implying larger and older females represent the most important group for population recruitment. In evaluating the relationship between reproductive output and ancestral associations to domestic pigs versus wild boar, the proportion of wild boar ancestry was not an important influence on productivity in our population. We determined juveniles reach a physiological threshold of sexual maturity at approximately 30 kg. Average litter size was comparable to other populations, and wild pigs maintain an average fetal litter size of 5.43 offspring despite 13.6% embryonic mortality. A thorough understanding of biotic and extrinsic factors influencing reproduction are important for realistic population models, which are necessary for identifying areas to focus management needs and implementation.
Modifications decrease hepatic steatosis in Taiwanese with metabolic‐associated fatty liver disease
Authors: Liu Tso‐Tsai , Qiu He , Liu Shi‐Yu , Chien Chieh , Wang Jen‐Hung , Wong Ming‐Wun , Yi Chih‐Hsun , Lin Lin , Lei Wei‐Yi , Liang Shu‐Wei , Hung Jui‐Sheng , Huang Jee‐Fu , Chen Chien‐Lin , Han Ma Ai Thanda 
Published: August 2022

AbstractMetabolic‐associated fatty liver disease (MAFLD) is a growing global problem associated with increasing obesity prevalence. Lifestyle modifications are currently recommended, including weight reduction, exercise, and diet control. This study evaluated the short‐term effect of lifestyle modifications on transient elastography (TE) values in an obese population with MAFLD. Thirty‐two MAFLD patients were recruited for this prospective study and all subjects participated in a 3‐month program of lifestyle modification. Sequential demographic parameters and biochemical tests were compared before and after program completion. Liver fat and fibrosis changes were measured using TE with controlled attenuated parameter (CAP) and liver stiffness measurements (LSM). The mean age was 38.7 years old (10 males). The body weight (88.09 kg vs. 80.35 kg), body mass index (32.24 kg/m2 vs. 29.4 kg/m2), waist (103.19 cm vs. 95.75 cm), and hip circumference (111.67 cm vs. 104.75 cm), and blood pressure (128/78 mmHg vs. 119/71 mmHg) significantly improved before and after the intervention, respectively. Aspartate aminotransaminase (24.06 U/L vs. 18.91 U/L), alanine aminotransaminase (33 U/L vs. 23.72 U/L), creatinine (0.75 mg/dl vs. 0.70 mg/dl), cholesterol (176.41 mg/dl vs. 166.22 m/dl), gamma‐glutamyl transferase (26.59 IU/L vs. 19.81 IU/L), and low‐density lipoprotein cholesterol (115.63 mg/dl vs. 103.19 mg/dl) also improved after the 3‐month intervention. The average CAP significantly decreased after intervention (297.5 dB/m vs. 255.0 dB/m), however, no significant difference in LSM was observed (5.24 kPa vs. 4.82 kPa). The current study suggests that short‐term lifestyle modification can effectively improve hepatic steatosis, and TE may serve as a monitoring tool for therapeutic intervention.
Validity of intraoperative voice monitoring undergoing type 2 thyroplasty with titanium bridges for adductor spasmodic dysphonia
Authors: Sanuki Tetsuji , Oridate Nobuhiko , Tateya Ichiro , Nito Takaharu , Mizoguchi Kenji , Tanabe Kenichiro 
Published: August 2022

AbstractObjectivesThe success of type 2 thyroplasty (TP2) for adductor spasmodic dysphonia (AdSD) depends on the selection of optimally sized titanium bridges, which requires accurate assessment of intraoperative vocal changes. While this procedure has traditionally been performed according to the laryngologist's experience, the most appropriate method for voice monitoring and selection of titanium bridge size remains to be determined. This study aimed to investigate evaluation parameters useful for voice monitoring, as these may allow less experienced surgeons to perform TP2 properly.MethodsIn this prospective study, voice monitoring was performed in 18 patients with AdSD patients undergoing TP2. Evaluations were performed preoperatively, intraoperatively, 13 weeks postoperatively, and 52 weeks postoperatively using GRBAS (grade, roughness, breathiness, asthenia, and strain), as well as perceptual judgment and acoustic analyses.ResultsPreoperative and intraoperative assessments of the G, R, B, and S parameters, perceptual judgment, and harmonic‐to‐noise ratio (HNR) were in moderate or better agreement. Intraoperative and 13‐ or 52‐week postoperative measurements of the R, B, and G parameters and strangulation, tremor, and HNR were also in high agreement. When two different sizes of titanium bridges were compared (unselected vs. selected), ratings for G, R, S, strangulation, tremor, jitter, shimmer, HNR, standard deviation of F0, and degree of voice breaks were better for the selected width than the unselected width.ConclusionThe candidate items for intraoperative voice monitoring during TP2 for AdSD are G, R, strangulation, tremor, and HNR. The use of these items may help to ensure successful TP2 and contribute to the advancement of laryngeal framework surgery.Level of evidenceLevel 4.
Sol–Gel Synthesis, Thermal Characterization, Surface Interactions, and Release Kinetics of Silica/Drug Hybrid System
Authors: Catauro Michelina , Blanco Ignazio , Clarke Ronald J. , Fiorentino Marika , D'Angelo Antonio , Raffaini Giuseppina 
Published: August 2022

AbstractControlled and local drug delivery systems of anti‐inflammatory agents are attracting increasing attention thanks to their possible pharmaceutical and biomedical applications. These systems have extended therapeutic effects and reduced side effects.The aim of this work is to synthesize a system composed of SiO2 glass and ketoprofen, an anti‐inflammatory drug, by the sol–gel process. Two different percentages (5 and 15 wt%) of drug are entrapped in the silica matrix via the sol–gel method and the dried material are analyzed via Fourier transform infrared spectroscopy (FTIR) and simultaneous Differential Scanning Calorimetery/Thermogravimetric analysis (DSC/TGA). The drug release kinetics of the amorphous bioactive materials are investigated. Molecular Mechanics and Molecular Dynamics simulations are currently in progress to investigate possible interactions between the silica‐based surface and the ketoprofen molecules both at low and high concentration for comparison with experimental data.
Electrical Investigation by Tunneling Atomic Force Microscopy of Carbon Fiber‐Reinforced Panels Manufactured by Modified Resin Film Infusion
Authors: Raimondo Marialuigia , Catauro Michelina , Reverchon Ernesto , Scognamiglio Mariarosa , Guadagno Liberata 
Published: August 2022

AbstractThe purpose of this work is the detection of the electrical current map by tunneling atomic force microscopy (TUNA) of carbon fiber‐reinforced panels (CFRPs). The impregnation of the CFRPs is carried out through a multifunctional epoxy formulation containing glycidyl polyhedral oligomeric silsesquioxane (GPOSS), for improving flame resistance, and multiwall carbon nanotubes (CNT) to contrast the electrical insulating properties of the epoxy resin. The multifunctional panels are manufactured by an appropriately modified resin film infusion (RFI) process. The effects of the different ply numbers (seven, 14, and 24) on the TUNA electrical performance are assessed. In particular, TUNA technique, which is able to detect ultralow currents ranging from 80 fA to 120 pA, allows to identify the conductive paths due to CNTs. The CNTs result firmly anchored to the carbon fibers of the fabric layers. The adopted manufacturing process allows the transit of the nanofilled resin avoiding filtration effects. TUNA's current images highlight the presence, in the interlayer space of carbon fibers, of conductive three‐dimensional networks of CNTs through the plies. This occurrence ensures good electrical properties of the multifunctional panels, which results suitable for advanced structural applications.
Structural and Morphological Characterization of Biopolymeric Samples Through AWJ Machining
Authors: Mărguță Daniel , Herghelegiu Eugen , Tâmpu Cătălin , Mazurchevici Simona‐Nicoleta , Petrescu Tudor , Nedelcu Dumitru 
Published: August 2022

AbstractIn order to identify the structure and morphology of the resulting surfaces from the abrasive water jet cutting, specialized analyses are performed. The biopolymers subjected to cold processing are Arboblend V2 Nature and Arbofill Fichte. According to the recorded data from the SEM (Scanning Electron Microscopy) and EDX (Energy‐dispersive X‐ray spectroscopy) analyses, uniformity as well as structural and morphological homogeneity of the samples is highlighted, together with the effect of the abrasive material, Garnet, on the structure and chemical composition of the cut surfaces. The abrasive outcome is found in the form of small streaks that has little influence on the roughness of the cut surfaces. Considering the obtained results, these biopolymers can be processed by cutting with an abrasive water jet in the conditions of obtaining a corresponding surface quality.
Complexation of pH‐Responsive Liposomal Nanocontainers with Polyanions for Manipulation with Release Properties and Adhesion to the Cell Surfaces
Authors: Tang Jian , Stepanova Darya , Sybachin Andrey 
Published: August 2022

AbstractThe impact of polyanions – sodium polystyrene sulfonate and sodium polyacrylate – on the rate of decapsulation of liposomal pH‐sensitive nanocontainers is investigated. The release properties are studied by means of laser microelectrophoresis and conductometery. Incorporation of capable to change its conformation after protonation trans‐4,5‐didodecyloxycarbonyl‐2‐morpholinocyclohexanol in electroneutral liposomes results in formation of pH‐sensitive nanocontainers (fliposomes) that release payload in slight acidic media. Pairing of this fliposomes with polyanions results in increase of rate of release of encapsulated water‐soluble compounds. Strong polyacid is found to induce release even at neutral pH. By means of fluorescence microscopy it is found that bare fliposomes being adsorbed on model cell membranes in acidic media while modified with polyanions nanocontainers provided release in intercellular environment.
Influence of Processing Methods on the Mechanical Behavior of Poly‐3‐hydroxybutyrate Nonwoven Scaffolds
Authors: Zykova Anna , Morokov Egor , Tyubaeva Polina 
Published: August 2022

AbstractThe theoretical prediction of the mechanical behavior of fibrous materials for medicine in different environments is of great scientific interest. The deformation mechanisms under loading of biopolymer electrospun fibrous materials differ significantly in dependence on the phase state of the medium, namely, liquid state, gaseous state, or at their interface. In this paper, the influence of various mediums on the mechanical behavior of fibrous materials based on poly‐3‐hydroxybutyrate under tension is examined. The oxidative stress (ozone treatment) and the incorporation of low concentrations of modifying additives (complexes of tetraphenyl‐porphyrin with Zn) are proposed as the most effective methods of directed control of stress‐related characteristics without a negative effect on the functional properties of medical materials.
Digital Modeling of the Characteristics of Biodegradable Polymers Using the Example of Compositions Based on Low Density Polyethylene with Natural Rubber
Authors: Varyan Ivetta , Bobkov Aleksandr 
Published: August 2022

AbstractDue to the growing environmental threat associated with the accumulation of plastic waste, the development of biodegradable polymers based on low‐density polyethylene with the addition of natural fillers is of great importance. At the same time, the experimental studies of such materials require a huge amount of time: the production cycle from the development of a new formulation of a biopolymer to market launch can take up to 36 months. To reduce this time, a new approach based on mathematical modeling is proposed. Verification of this approach is carried out using the example of low‐density polyethylene composites with natural rubber filler. The high accuracy of the proposed mathematical models for predicting the properties of biodegradable polymers is shown.
Post Low Velocity Impact Vibration Response of Bio‐Composite Flax/Epoxy Plates: Validation of Experiment Setup
Authors: Srihi Khouloud , Massé Nadia , El‐Hafidi Ali , Rousseau Jérôme , Martin Bruno 
Published: August 2022

AbstractBiocomposite materials are increasingly used in industrial transport structures (aerospace and automotive). They offer the ability to design complex parts, lightweight shapes that respond to high mechanical performance. Flax fibers are the most widely used because of their availability and mechanical properties, competitive to the properties of glass fibers. The detection of damage in these structures is essential to anticipate perilous consequences. Impacts induced damage is the most critical. The health control of a structure requires information about the severity and location of a damage through nondestructive methods. The aim of this study is to investigate vibratory behavior due to the impact on a biocomposite structure (flax/epoxy) to detect and evaluate the damage induced in noncontact method.
The Effect of Crosslink Density on the Physical and Mechanical Properties of Bio‐Based Polyurethane Foams
Authors: Andersons Janis , Cabulis Peteris , Kirpluks Mikelis 
Published: August 2022

AbstractRigid low‐density closed‐cell polyurethane foams with different crosslink densities have been produced using biobased polyols derived from tall oil. Mechanical and dilatometric tests reveal that the transverse stiffness and tensile strength of the foams increased with growing crosslink density both at the room and cryogenic temperatures, while the coefficient of linear thermal expansion exhibited an opposite trend. Cryogenic safety factors, estimated based on the foam properties obtained, reveal no consistent trend with changing crosslink density of the polyurethane polymer.
Impact of Freezing Conditions on the Morphology and Mechanics of PVA‐Based Sponge‐Like Materials
Authors: Antipova Christina G. , Bazyleva Christina Y. , Krasheninnikov Sergey V. , Sharikov Roman V. , Malakhov Sergey N. , Patsaev Timofey D. , Chvalun Sergey N. , Grigoriev Timofei E. 
Published: August 2022

AbstractHighly porous polymer materials have been studied a lot for applications in biotechnology and biomedicine, because of their high surface area and percolated pore structure. Varying processing conditions, in this study, can tune the morphology, mechanical, and physicochemical characteristics of the materials. In the present work, cross‐linked poly(vinyl alcohol)‐based freeze‐dried sponges linked by glutaraldehyde are studied. The current study analyzes the influence of cooling speed on the sponge's morphology and mechanical properties. Complex analysis of the tests carried out shows agreement in morphology, surface area, equilibrium degree of swelling, and mechanical properties of the sponges with dependence on the amount of cross‐linking agent and freezing conditions.
The Behavior of a 3D Printed Panel under Thermal Stress
Authors: Mihalache Andrei , Hriţuc Adelina , Slătineanu Laurentiu , Nagîț Gheorghe , Dodun Oana , Ermolai V. , Panaite E. 
Published: August 2022

AbstractPLA‐based panels are widely used in many applications. Sometimes these panels can be subjected to uneven heating processes of their various areas. As the cooling process also has a nonuniform character, the appearance of residual stresses of thermal nature is expected, which can lead to the appearance of residual plastic deformations of the panel. Finite element modeling and images taken with the help of an infrared camera confirm the process of uneven panel heating under the action of heat generated by an infrared radiation lamp. The models made using the finite element method concluded that deviations are possible in the form of a concavity in that area of ​​the panel surface located closer to the heat source and in the form of convexity on the opposite surface. The experimental results obtained on polylactic acid panels with thicknesses of 2 and 4 mm confirm the generation by uneven cooling of shape deviations with sizes up to 3.39 mm.
Tensile Strength Analysis of the Ring‐Shape 3D Printed Polymer Parts
Authors: Hrițuc Adelina , Slătineanu Laurentiu , Rîpanu M. , Mihalache Andrei , Nagîț Gheorghe , Dodun Oana 
Published: August 2022

AbstractThe uses of polymers in various fields are no longer a novelty. The diversity of these uses started from the study of polymers' properties, which revealed the ability of these materials to meet the different requirements to which the polymer parts are subjected in real use. Tensile strength is one of the basic requirements that can highlight the strength and use properties. The polymer's choice and the way to generate certain stresses in the polymer parts highlight some interesting aspects of using 3D printing to make parts with a certain geometry. Thus, ring‐type parts made of polylactic acid and with a constant cross‐section suppose a certain distribution of efforts in the case of mechanical stresses, such as tensile stress. The finite element simulation method is used to highlight the tensile behavior of ring‐type parts made of the polymer by 3D printing. Experimental tests are also performed to highlight the influence of some input factors in the 3D printing process on tensile strength. An empirical mathematical model has been identified to illustrate the influence of input factors used on the tensile strength of the test piece material. The experimental research also allows a comparison of the results with those obtained by using the finite element method.
Numerical and Experimental Investigations of Thermal Conductivity of 3D Printed Polylactic Acid
Authors: Panaite Carmen Ema , Mihalache Andrei Marius , Slătineanu Laurențiu , Popescu Aristotel , Nagîț Gheorghe , Hrițuc Adelina , Dodun Oana 
Published: August 2022

AbstractPolylactic acid (PLA) is a plastic material used occasionally for thermal insulation. Thus, information is required with respect to the thermal insulation property specific to various types of PLA. On the other hand, the development of 3D printing processes has led to ensuring the conditions for manufacturing PLA parts, with properties that can be modified by varying the input factors of printing process. The proposed experimental research method uses the measurement of temperature variation on one surface of PLA panel, while applying a cooling process on the opposite surface. Several panels with different characteristics are tested. The experimental results are processed using a specialized software and an empirical mathematical model is developed. The model highlights the influence of panel thickness, cooling duration, infill, and deposited layer thickness with respect to the temperature of the panel surface opposite to the cooled one.
A Degradation Study of Poly(3‐Hydroxybutyrate‐Co‐3‐Hydroxyvalerate) and Olive Husk Flour Biocomposites Under Marine Environment
Authors: Hassaini Leila , Kaci Mustapha , Dehouche Nadjet , Bruzaud Stéphane 
Published: August 2022

AbstractIn this work, the main objective is to investigate the effect of olive husk flour (OHF) used as a biofiller on the marine degradation of poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV) biocomposites up to 6 months of immersion in sea water at 25°C and 40°C. Film samples based on neat PHBV and PHBV are filled with 20 wt.% OHF is prepared by melt compounding. After 6 months of immersion in sea water, the study reveals a noticeable decrease in the absorption band intensity of ester groups of PHBV through Fourier transform infrared (FTIR‐ATR) spectroscopy, even more in the presence of OHF in PHBV biocomposite due to hydrolytic degradation. This phenomenon is, however, more pronounced at 40°C. This also agrees with differential scanning calorimetry (DSC) data, which indicates a large increase in crystallinity index (Xc) resulting from short chains reorganization. Moreover, scanning electron microscopic (SEM) analysis shows for both degraded samples, eroded and cracked surfaces, being however more pronounced for PHBV/OHF biocomposite at 40°C. This study highlights the role of OHF as a promotor of marine degradation of PHBV.