bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychotherapy Combined with Western Medicine in the Treatment of Children with Tic Disorder: Systematic Review and Meta-Analysis
Authors: Kong Yamin , Zhang Xueyuan , Ma Bingxiang 
Published: April 2022

Objective. To evaluate the efficacy of psychotherapy in children with tic disorder and to provide basis for the application of psychotherapy in the treatment of children with tic disorder. Methods. A detailed search was conducted based on PubMed, Cochrane library database, CNKI, Wanfang Data, and VIP database to determine the randomized controlled trial (RCT) of psychotherapy combined with drugs and oral drugs in the treatment of tic disorder. The search time was from the establishment of the database to August 20, 2021. All kinds of extracted data are meta analyzed, and the statistical software used is Review Manager 5.3 software. Results. According to the inclusion and exclusion criteria, 14 clinical trials were finally included, including 513 TD children, including 267 in the psychological intervention group and 246 in the control group. All trials were conducted in China and published from 2013 to 2021. In terms of clinical efficacy, compared with the control group, the psychotherapy combined with drugs group had more advantages in improving the effective rate (

RR
=
3.25

, 95% CI: 2.17~4.85,

Z
=
5.74

,

P
<
0.00001

) and improving the clinical symptoms of children with TD (

WM
=
−
5.36

, 95% CI: -6.41 ~ -4.30,

Z
=
9.97

,

P
<
0.00000

1

). Conclusion. Psychotherapy as an adjuvant therapy for clinical treatment of TD can improve the clinical efficacy, but due to the low methodological quality of the existing trials, the research may have potential bias. In the future, large sample, multicenter, and double-blind randomized controlled trials need to be carried out to provide further support.
Intratumor Heterogeneity and Antitumor Immunity Shape One Another Bidirectionally
Authors: Wolf Yochai , Samuels Yardena 
Published: April 2022

Abstract
Over the last decade, it has become clear that the genomic landscapes of tumors profoundly impact their immunogenicity and how tumor cells interact with immune cells. Whereas past discoveries mainly focused on the interplay between tumor immunogenicity and tumor mutational burden (TMB), under the assumption that a higher mutation load would give rise to a better patient response to immune checkpoint blockade therapies, we and others have underlined intratumor heterogeneity (ITH) as an important determinant of the magnitude of the antitumor response and the nature of the tumor microenvironment. In this review, we define TMB versus ITH and how the two factors are being inferred from data, examine key findings in the cancer immunogenomics literature deciphering the complex cross-talk between TMB, ITH, and antitumor immunity in human cancers and in vivo models, and discuss the mutual influence of ITH and immunity—how the antitumor response can give rise to tumors with higher ITH, and how higher ITH can put shackles on the antitumor response.
Targeting Podoplanin for the Treatment of Osteosarcoma
Authors: Takemoto Ai , Takagi Satoshi , Ukaji Takao , Gyobu Nobuhiko , Kakino Mamoru , Takami Miho , Kobayashi Asami , Lebel Marie , Kawaguchi Tokuichi , Sugawara Minoru , Tsuji-Takayama Kazue , Ichihara Kenji , Funauchi Yuki , Ae Keisuke , Matsumoto Seiichi , Sugiura Yoshiya , Takeuchi Kengo , Noda Tetsuo , Katayama Ryohei , Fujita Naoya 
Published: April 2022

AbstractPurpose:Osteosarcoma, the most common bone malignancy in children, has a poor prognosis, especially when the tumor metastasizes to the lungs. Therefore, novel therapeutic strategies targeting both proliferation and metastasis of osteosarcoma are required. Podoplanin (PDPN) is expressed by various tumors and is associated with tumor-induced platelet activation via its interaction with C-type lectin-like receptor 2 (CLEC-2) on platelets. We previously found that PDPN contributed to osteosarcoma growth and metastasis through platelet activation; thus, in this study, we developed an anti-PDPN humanized antibody and evaluated its effect on osteosarcoma growth and metastasis.Experimental Design:Nine osteosarcoma cell lines and two osteosarcoma patient-derived cells were collected, and we evaluated the efficacy of the anti-DPN-neutralizing antibody PG4D2 and the humanized anti-PDPN antibody AP201, which had IgG4 framework region. The antitumor and antimetastasis effect of PG4D2 and AP201 were examined in vitro and in vivo. In addition, growth signaling by the interaction between PDPN and CLEC-2 was analyzed using phospho-RTK (receptor tyrosine kinase) array, growth assay, or immunoblot analysis under the supression of RTKs by knockout and inhibitor treatment.Results:We observed that PG4D2 treatment significantly suppressed tumor growth and pulmonary metastasis in osteosarcoma xenograft models highly expressing PDPN. The contribution of PDGFR activation by activated platelet releasates to osteosarcoma cell proliferation was confirmed, and the humanized antibody, AP201, suppressed in vivo osteosarcoma growth and metastasis without significant adverse events.Conclusions:Targeting PDPN with a neutralizing antibody against PDPN–CLEC-2 without antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity is a novel therapeutic strategy for PDPN-positive osteosarcoma.
Lenalidomide and the Expanding Toolkit to Manage Kaposi Sarcoma
Authors: Henry David H. , Maki Robert G. 
Published: April 2022

Summary
Lenalidomide recently was shown to have clinical activity in patients with human immunodeficiency virus—associated Kaposi sarcoma. Immunomodulatory imine drugs thus provide another tool in the treatment of this challenging neoplasm.
See related article by Reid et al., p. 2646
PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86 Expression, Growth, and Survival
Authors: Moser-Katz Tyler , Gavile Catherine M. , Barwick Benjamin G. , Lee Kelvin P. , Boise Lawrence H. 
Published: April 2022

AbstractDespite advances in the treatment of multiple myeloma in the past decades, the disease remains incurable, and understanding signals and molecules that can control myeloma growth and survival are important for the development of novel therapeutic strategies. One such molecule, CD86, regulates multiple myeloma cell survival via its interaction with CD28 and signaling through its cytoplasmic tail. Although the CD86 cytoplasmic tail has been shown to be involved in drug resistance and can induce molecular changes in multiple myeloma cells, its function has been largely unexplored. Here, we show that CD86 cytoplasmic tail has a role in trafficking CD86 to the cell surface. This is due in part to a PDZ-binding motif at its C-terminus which is important for proper trafficking from the Golgi apparatus. BioID analysis revealed 10 PDZ domain–containing proteins proximal to CD86 cytoplasmic tail in myeloma cells. Among them, we found the planar cell polarity proteins, SCRIB and DLG1, are important for proper CD86 surface expression and the growth and survival of myeloma cells. These findings indicate a mechanism by which myeloma cells confer cellular survival and drug resistance and indicate a possible motif to target for therapeutic gain.Implications:These findings demonstrate the importance of proper trafficking of CD86 to the cell surface in myeloma cell survival and may provide a new therapeutic target in this disease.
All as One to One for All
Authors: Gardner Nathan Daniel 
Published: April 2022

Abstract
The recent racism toward Chinese Australians arising from the COVID-19 pandemic recalls the shape and scale of racism last seen during the “Hanson debate” of the late 1990s – so-named for the anti-Asian immigration and anti-multicultural positions Pauline Hanson advanced in Australian politics and society. Further linking these two moments are the responses to racism coming from Chinese Australian individuals and community organizations. In each period, the different backgrounds of various Chinese Australian communities and their representative organizations influenced their modes of responding to racism. Over the years, however, the prominence of a small number of “community leaders” and organizations responding to racism has increasingly eclipsed grassroots responses to racism. I argue that this shift represents a “professionalization” of Chinese Australian responses to racism; partly explaining the form that present responses take, while also problematizing the relationship between the “community representatives” and the “communities being represented.”
Islam and the Invention of Religion: A Study of Medieval Muslim Discourses on Dīn
Authors: Abbasi Rushain 
Published: April 2022

Abstract
In recent years, the validity of the category of religion has been increasingly subjected to severe criticism across several academic disciplines. The thrust of this critical position – despite the nuances and sophistication of the various arguments advanced in support of it – rests, in the main, on one central claim: that the notion of religion did not exist in non-Western and premodern civilizations and is therefore a unique invention of the modern West. It is my contention, however, that in fixating on the Western construction of the category of religion and the theoretical problems associated with it, scholars have neglected to consider whether a similar concept might have existed prior to the modern West, and if so, what this might mean for our understanding of religion as a historical phenomenon. As a remedy to this trend, this article will engage in a comprehensive conceptual historical analysis of the Arabic term dīn (and its related terminology) in order to demonstrate that, contrary to popular belief, premodern Muslims did indeed possess a concept akin to the modern sense of “religion” long before the rise of the modern West, and that, furthermore, they were the first historical community to sustain and develop a rich and robust analytical discourse around the idea of religion, which consequently played a major role in various social, political, and intellectual endeavors in Islamic history. My investigation will reveal that premodern Muslims continuously redefined and repurposed the concept of religion (based on a readily available conceptual vocabulary produced within the Late Antique Near East) in the process of offering particular sociological accounts of the origins and nature of religion, addressing political concerns like the unravelling of power, classifying the “Other,” and more.
Reconstructing Early Ibāḍī Theology in North Africa: The influence of ʿAbdallāh b. Yazīd al-Fazārī
Authors: al-Salimi Abdulrahman 
Published: April 2022

Abstract
This paper seeks to re-examine previous comparative work done on one of North Africa’s most important Ibāḍī theological texts, al-Radd ʿalā al-Jahālāt, through the wider lens of the development of Ibāḍī theology and Ibāḍī creedal literature in North Africa. More specifically, this paper will look at the influence of the key text Kitāb al-Tawḥīd by the Ibāḍī theologian ʿAbdullah b. Yazīd al-Fazārī on a wide range of theological discussions that took place in the process of the formation of Ibāḍī creeds, and specifically on Kitāb al-Tawḥīd’s influence on the text of al-Radd ʿalā al-Jahālāt. That work will enable us to draw firmer conclusions on al-Fazārī’s place in the different debates between opposing Ibāḍī camps in North Africa during the period of Ibadi formation, and from there on through the centuries.
Continuity and Change in the Role of Mysticism under the Islamic Republic of Iran
Authors: Machlis Elisheva 
Published: April 2022

Abstract
The current study will evaluate the role of ‘irfān [the inner perception of knowledge; combining elements of philosophy, theosophy, mysticism and Shi’i thought] within the Islamic Republic of Iran as a significant component of Iran’s cultural heritage. It will focus on several prominent clerics and intellectuals who represent the regime’s diverse political factions. This article will demonstrate that under the Islamic Republic, ‘irfān evolved from a marginalized area to a central phenomenon and became a tool to debate the political direction of the state and the relationship between its revolutionary and republican elements. While mysticism in the service of politics was more wide-spread among the reformist camp, ardent supporters of the regime resorted to ‘irfān to enhance an exclusive perception of authority based on the rule of the Supreme Jurist. It also created a shared spiritual basis among the Islamic State’s diverse voices. The result was a new blend between mysticism, philosophy, Western thought, politics, Islamic law, and even messianism, within an inter-connectivity between the mystical path and the Shari‘a. Consequently, a complex understanding of ‘irfān has to take into consideration the multiple fusions between Islamic mysticism and other trends and evaluate the result in a specific socio-political context.
Explaining Extreme Events of 2020 from a Climate Perspective
Authors: Herring Stephanie C. , Christidis Nikolaos , Hoell Andrew , Stott Peter A. 
Published: April 2022

Abstract
Editors note: For easy download the posted pdf of the Explaining Extreme Events of 2020 is a very low-resolution file. A high-resolution copy of the report is available by clicking here. Please be patient as it may take a few minutes for the high-resolution file to download.
Systematic review of Indigenous involvement and content in mental health interventions and their effectiveness for Indigenous populations
Authors: Lee Rachel Seungyun , Brown Hilary K , Salih Sarah , Benoit Anita C 
Published: April 2022

Objective:To assess the effects of psychological, psychosocial, educational and alternative interventions on mental health outcomes of Indigenous adult populations in Australia, Canada, New Zealand and the United States and the Indigenous involvement and content in each study.Methods:We systematically searched databases, key journals and gray literature, for records until June 2020. Eligible studies were in English or French and examined the impact of interventions on mental health outcomes including anxiety disorders, posttraumatic stress disorder, depression, psychological distress or stress for Indigenous adults (⩾16 years). Data were extracted using a modified Cochrane Data Extraction Form and the Template for Intervention Description and Replication. Quality was evaluated using the Effective Public Health Practice Project quality assessment form.Results:In total, 21 studies were eligible, comprising 8 randomized controlled trials, 10 single-group pre–post studies and 3 pre–post studies with comparison groups. Twenty studies had Indigenous individuals or organizations involved in some decision-making capacity, though extent of involvement varied widely. In total, 9 studies were rated moderate and 12 weak in the Effective Public Health Practice Project quality assessment. Eight studies measuring depression, three measuring posttraumatic stress disorder, three measuring psychological distress and two measuring stress showed statistically significant improvements following the intervention.Conclusion:A wide range of interventions demonstrated mental health improvements. However, it is difficult to draw generalizable conclusions on intervention effectiveness, given heterogeneity among studies. Studies should employ a thorough assessment of the Indigenous involvement and content of their interventions for reporting and for critical consideration of the implications of their research and whether they address Indigenous determinants of mental health.
Occult Metastases During Salvage Oral Cavity and Oropharyngeal Free Flaps: Oncologic Outcomes
Authors: Wieser Margaret E. , Sagalow Emily S. , Givens Alyssa , Curry Joseph M. , Dooley Laura M. , Galloway Tabitha L. , Zitsch Robert P. , Tassone Patrick T. 
Published: April 2022

ObjectivesTo define rates of occult metastases in salvage oral cavity and oropharyngeal cancer resection requiring free flap, to examine the location of occult metastases, and to determine associations between occult metastasis and survival.Study DesignRetrospective cohort study.SettingTwo tertiary care referral centers.MethodsWe identified previous cases of irradiation with recurrent or second primary oral cavity or oropharyngeal squamous cell carcinoma that had no evidence of regional metastasis and required free tissue transfer reconstruction of the primary site. Patients who underwent elective neck dissection or exploration were reviewed. The main outcome measures were the presence and location of occult nodal metastasis. Disease‐free survival and overall survival were measured. Odds ratios and hazard ratios were used for analysis.ResultsA total of 83 patients were included: 52 with oral cavity primary tumors and 31 with oropharynx. An overall 78 (94%) underwent elective salvage neck dissection. Occult metastases were found in 9 (11.5%) patients. The most common nodal station for occult metastasis was level 2. Neither elective neck dissection nor the presence of occult metastasis was significantly associated with regional disease‐free or overall survival. Oropharyngeal primary tumors were associated with higher risk of occult metastasis (odds ratio, 1.38; P <. 01) and worse overall survival (hazard ratio, 2.09; P =. 01).ConclusionThere is a low incidence of occult metastasis in postradiated recurrent or second primary oral cavity and oropharyngeal tumors. Elective neck dissection and occult nodal metastases were not associated with regional or overall survival. This series may help surgeons make decisions regarding the extent of neck surgery after prior radiation, especially when free flap reconstruction is required.
Orthodontic Management of Severe Dentoalveolar Collapse with Miniscrew-Assisted TMA Cantilever Springs and Bite Blocks
Authors: Venkatesh Pallavi , Harish Pooja , Madakkuni Anjuna , Reddy Sumitra 
Published: April 2022

Introduction: Management of mutilated cases is challenging, and adult patients often require orthodontic correction of occlusion before prosthetic replacement of missing teeth. Objective: To highlight the novel, simple, hygienic, and efficient miniscrew-supported Beta titanium molybdenum alloy (TMA) cantilever spring for uprighting severe mesially tipped molars for interdisciplinary treatment. Diagnosis and Treatment: A 23-year-old male patient presented with skeletal Class I relation, average growth pattern, Class II Division 1 malocclusion with dentoalveolar collapse, crowding, multiple missing, supraerupted teeth, and severe mesially tipped mandibular third molars. MBT appliance with 0.022˝ slot was used to achieve the objectives. 38 and 48 were uprighted and protracted with miniscrew implant-supported TMA cantilever springs to substitute 37 and 47. Mild intrusion of maxillary posterior teeth was done with acrylic bite blocks and transpalatal arch (TPA), followed by prosthetic replacement of missing teeth. Results: The patient had a consonant smile arc and a pleasing soft tissue profile. 38 and 48 were uprighted and protracted with good vertical control, and the mesial pockets were eliminated. 17 and 27 were intruded, and group function occlusion was established. Class I canine relationship, normal overjet, and overbite were achieved. Conclusion: Miniscrew supported TMA cantilevers are efficient for uprighting of severely tipped 38 and 48 without extrusion, unlike the conventional mechanics. 18, 28, 38 and 48 with good root forms can be protracted and substituted as 17, 27, 37 and 47 respectively to minimize or eliminate prosthetic rehabilitation.
Vaccine and Psychological Booster: Factors Associated With Older Adults’ Compliance to the Booster COVID-19 Vaccine in Israel
Authors: Ben-David Boaz M. , Keisari Shoshi , Palgi Yuval 
Published: April 2022

Israel became the first country to offer the booster COVID-19 vaccination. The study tested for the first time the role of sense of control (SOC) due to vaccinations, trust and vaccination hesitancy (VH), and their association with compliance to the booster COVID-19 vaccine among older adults, during the first 2 weeks of the campaign. 400 Israeli citizens (≥ 6 years old), eligible for the booster vaccine, responded online. They completed demographics, self-reports, and booster vaccination status (already vaccinated, booked-a-slot, vaccination intent, and vaccination opposers). Multinomial logistic regression was conducted with pseudo R 2 = .498. Higher SOC and lower VH were related to the difference between early and delayed vaccination (booked-a-slot, OR = 0.7 [0.49‐0.99]; 2.2 [1.32‐3.62], intent OR = 0.6 [0.42‐0.98]; 2.7 [1.52‐4.86]), as well as to rejection ( OR = 0.3 [0.11‐0.89]; 8.5 [3.39‐21.16]). Increased trust was only related to the difference between early vaccinations and vaccine rejection ( OR = 0.3 [0.11‐0.89]). We suggest that SOC, as well as low VH, can be used as positive motivators, encouraging earlier vaccinations in older age.
Comparison of clinical presentation and outcome of childhood-onset and adulthood-onset of systemic lupus erythematosus among Indonesian patients
Authors: Hamijoyo Laniyati , Sapartini Gartika , Rahmadi Andri R , Wachjudi Rachmat G , Dewi Sumartini , Ghrahani Reni , Praptama Suhendra , Rainy Nisa R , Usman Stefanie Y , Suryajaya Bernard S , Candrianita Sasfia , Sutedja Endang , Setiabudiawan Budi 
Published: April 2022

Introduction The clinical presentation of childhood-onset systemic lupus erythematosus (SLE) is generally perceived to differ from that of adult-onset SLE. Objective We aimed to compare the demographic and clinical manifestation between childhood-onset vs. adult-onset SLE in a cohort of Indonesian patients at tertiary care centers. Methods This retrospective study included patients in the Hasan Sadikin Lupus Registry from 2008 until December 2017. The demographics, clinical presentations, and outcomes were compared between childhood-onset SLE (<18 years old) (Group 1) and adult-onset SLE (≥18 years old) (Group 2). Results Eight hundred seventy patients were involved into this study. The proportion of childhood-onset SLE was 20% (174 patients). The mean age of group 1 versus group 2 was 13.56 ± 3.04 vs 30.41 ± 8.54 years. The following clinical manifestations at SLE diagnosis were significantly more common in childhood-onset than in adult-onset SLE patients: hematological disorder ( p = 0.033) and arthritis ( p = 0.006). While discoid rash ( p = 0.036) and photosensitivity ( p < 0.001) were significantly found higher in adult-onset SLE. Cyclophosphamide therapy was significantly more common to be used in childhood-onset (38.5% vs 21.0%, p = <0.001). However, frequency of mortality on follow-up tended to be higher in childhood-onset group (11.5% vs 7.0%, p = 0.208). Conclusion Arthritis and hematologic involvements at SLE diagnosis were more prominent in childhood-onset compared to adult-onset patients, and mortality in childhood-onset SLE during follow-up relatively higher. This data may suggest the need for more aggressive management approach to childhood-onset patients with SLE.