bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma
Authors: Devin Julie , Cañeque Tatiana , Lin Yea-Lih , Mondoulet Lucie , Veyrune Jean-Luc , Abouladze Matthieu , Garcia De Paco Elvira , Karmous Gadacha Ouissem , Cartron Guillaume , Pasero Philippe , Bret Caroline , Rodriguez Raphaël , Moreaux Jerome 
Published: January 2022

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common hematological malignancy. Although more than half of patients with DLBCL achieve long-term remission, the majority of remaining patients succumb to the disease. As abnormal iron homeostasis is implicated in carcinogenesis and the progression of many tumors, we searched for alterations in iron metabolism in DLBCL that could be exploited to develop novel therapeutic strategies. Analysis of the iron metabolism gene expression profile of large cohorts of patients with DLBCL established the iron score (IS), a gene expression–based risk score enabling identification of patients with DLBCL with a poor outcome who might benefit from a suitable targeted therapy. In a panel of 16 DLBCL cell lines, ironomycin, a promising lysosomal iron-targeting small molecule, inhibited DLBCL cell proliferation at nanomolar concentrations compared with typical iron chelators. Ironomycin also induced significant cell growth inhibition, ferroptosis, and autophagy. Ironomycin treatment resulted in accumulation of DNA double-strand breaks, delayed progression of replication forks, and increased RPA2 phosphorylation, a marker of replication stress. Ironomycin significantly reduced the median number of viable primary DLBCL cells of patients without major toxicity for nontumor cells from the microenvironment and presented low toxicity in hematopoietic progenitors compared with conventional treatments. Significant synergistic effects were also observed by combining ironomycin with doxorubicin, BH3 mimetics, BTK inhibitors, or Syk inhibitors. Altogether, these data demonstrate that a subgroup of high-risk patients with DLBCL can be identified with the IS that can potentially benefit from targeting iron homeostasis.

Significance:
Iron homeostasis represents a potential therapeutic target for high-risk patients with DLBCL that can be targeted with ironomycin to induce cell death and to sensitize tumor cells to conventional treatments.
Is Serotonin the Missing Link between COVID-19 Course of Severity in Patients with Diabetes and Obesity?
Authors: Santos Ana Paula , Couto Carlos Ferreira , Pereira Sofia Silva , Monteiro Mariana Pereira 
Published: January 2022

COVID-19 is an intriguing infectious condition with multisystemic manifestations and variable outcomes that are influenced by the concomitant presence of non-communicable diseases, such as obesity, diabetes, and cardiovascular disease, which were previously well established epidemics and therefore are considered global syndemics. Although an enormous progress towards understanding mechanisms of SARS-CoV-2 infection leading to COVID-19 has been made, there are still many areas of uncertainty to clarify. Systemic diseases are characterized by common links that allow integrating apparently unrelated disease manifestations. The authors launch the provocative hypothesis that serotonin is the putative mediator linking the lung, gut, cardiac, neurological, and other systemic manifestations that characterize severe COVID-19 in individuals with diabetes and obesity. In support of a role for serotonin in the mechanisms leading to disease severity are the similarities between acute and post-acute COVID-19 manifestations and neuroendocrine tumors presenting with carcinoid syndrome. Scientific discussion is set by highlighting the available clues that support this working hypothesis to trigger future research aimed at unravelling the molecular pathways underlying SARS-CoV-2 infection that are still far from being fully disclosed.
Impact of Number of Passes Before Rescue Therapy in Thrombectomy for Basilar Artery Strokes
Authors: Lun Ronda , Walker Gregory , Weisenburger‐Lile David , Lapergue Bertrand , Guenego Adrien , Heran Navraj , Siu William , Dargazanli Cyril , Benali Amel , Gory Benjamin , Richard Sébastien , Ducroux Célina , Piotin Michel , Blanc Raphael , Labreuche Julien , Lucas Ludovic , Haddad John , Aubertin Mathilde , Vannier Stéphane , Guillen Maud , Eugene François , Maier Benjamin , Marnat Gaultier , Detraz Lili , Bourcier Romain , Fahed Robert ,   for the ETIS investigators (list of investigators at the end of the article)
Published: January 2022

Background
When standard endovascular thrombectomy techniques fail to achieve a successful recanalization, it is often necessary to use rescue therapies (RTs). RTs are more commonly used in basilar artery occlusions and conventionally thought to represent “a last resort option.” We sought to study the outcomes of basilar artery occlusion patients who received RT, and further hypothesize that the number of instrumental passes before initiation of RT may be associated with increased risk for poor clinical outcomes.

Methods
We performed a retrospective analysis of the ETIS (“Endovascular Treatment in Ischemic Stroke”) registry. Our primary analysis included 277 patients who underwent thrombectomy for basilar artery occlusion, of whom 74 patients (26.7%) who received RT, defined as the use of intra‐arterial drugs, angioplasty, or stenting. Primary outcome measures included successful or complete reperfusion (final modified thrombolysis in cerebral infarction ≥2b or 3), functional independence (modified Rankin scale of 0–2), and mortality at 3 months.

Results
RT patients were more likely to have an atherosclerotic cause than non‐RT patients (46/74 [62.2%] versus 38/203 [18.7%]), were more likely to die (42/74 [56.8%] versus 73/203 [36.0%]), and were less likely to achieve functional independence (12/74 [16.2%] versus 84/203 [41.4%]). In the RT cohort, 17 of 74 patients (23.0%) had 1 pass before RT initiation, and 8 of 17 (47.1%) achieved a modified Rankin scale score of 0 to 2 at 3 months, with a mortality rate of 23.5% (4/17). The chance of achieving good clinical outcome decreased with each additional pass, whereas mortality increased. The odds of mortality at 3 months were highest in the >3 passes group, with an odds ratio of 10.29 (95% CI, 2.42–43.81) compared with 1 pass. None of the 25 patients with >3 passes before RT achieved 3‐month functional independence.

Conclusions
There is a significant correlation between the number of passes before initiation of RT and 3‐month clinical outcomes in basilar artery occlusion patients.
Multistep Forecasting of Soil Moisture Using Spatiotemporal Deep Encoder–Decoder Networks
Authors: Li Lu , Dai Yongjiu , Shangguan Wei , Wei Nan , Wei Zhongwang , Gupta Surya 
Published: January 2022

Abstract
Accurate spatiotemporal predictions of surface soil moisture (SM) are important for many critical applications. Machine learning models provide a powerful method for building an accurate and reliable predictive model of SM. However, the models used in recent studies have some limitations, including lack of spatial autocorrelation (SAC), vague representation of important features, and primarily focused on the one-step forecast. Thus, we proposed an attention based convolutional long-short term memory model (AttConvLSTM) for multistep forecasting. The model includes three layers; spatial compression, axial attention, and encoder-decoder prediction, which are used for compressing spatial information, feature extraction, and multistep prediction, respectively. The model was trained using surface SM from Soil Moisture Active Passive L4 product at 18km spatial resolution over the United States. The results show that AttConvLSTM predicts 24 hours ahead SM with mean R2 and RMSE is equal to 0.82 and 0.02, respectively. Compared with LSTM, AttConvLSTM improves the model performance over 73.6% of regions, with an improvement of 8.4% and 17.4% in R2 and RMSE, respectively. The performance of the model is mainly influenced by temporal autocorrelation (TAC). Moreover, we also highlight the importance of SAC on model performance, especially over regions with high SAC and low TAC. Moreover, our model is also competent for SM predictions from several hours to several days, which could be a useful tool for predicting all meteorological variables and forecasting extremes.
Supporting vulnerable students: Staff and parents speak
Authors: Testa Doris 
Published: January 2022

Background: Schools are at the forefront of promoting positive mental health and wellbeing through the implementation of evidence-based actions. Few Australian studies however have explored the views and experiences of school staff and parents as to what best supports secondary school students who struggle with positive mental health. Aims: This article describes findings from an exploratory study looking at the views and experiences of 74 staff and parents at four Melbourne Catholic Secondary schools. The study sought to understand how staff and parents experienced, offered and understood support to vulnerable secondary school students. Methods: The review and analysis drew on data collected from four staff groups and four parent focus groups. Participants in each group shared their views as to what they considered effective support to vulnerable secondary school students. Results: Findings indicated that the destigmatisation of mental ill-health conditions, greater attention to the transition between primary and secondary school, and the display of unconditional positive regard are critical to supporting vulnerable young students. Conclusion: Strengthening support to vulnerable young students requires school structures that (a) mitigate against stigmatisation, (b) recognise the period between childhood and adulthood as a time of heightened risk and (c) include staff whose posture towards vulnerable young students is one of unconditional positive regard.
Identifying Patient Characteristics That Predict Drug‐Induced Sleep Endoscopy Anatomy
Authors: Gao Thomas Zhang , Pan Xueliang , Naik Akash , Khandalavala Rohan , Ramsell Stuart , Gibbs Hannah , Chio Eugene 
Published: January 2022

ObjectiveTo examine if age, sex, body mass index (BMI), neck circumference, or apnea‐hypopnea index can predict whether a patient will demonstrate velopharyngeal complete circumferential (CC) collapse on drug‐induced sleep endoscopy (DISE).Study DesignSingle‐center retrospective review at The Ohio State Wexner Medical Center of 289 patients between March 2014 and June 2020.SettingQuaternary care hospital.MethodsPatient characteristic and DISE information was extracted from charts and summarized with mean and standard deviation for continuous variables and count and percentage for categorical. CC collapse and patient characteristic associations were explored: 2‐sample t test for continuous and chi‐square test for categorical. Classification and regression tree (CART) analysis with 3‐fold cross‐validation was employed to search for the best CC collapse predictors.ResultsMale and female BMI and female neck circumference were correlated to velopharyngeal CC collapse, with BMI more strongly correlated. CART analysis for males showed that a BMI ≤34.8 kg/m2 is associated with an 89.4% chance of not demonstrating velopharyngeal CC collapse vs 48% for BMI >34.8 (area under the curve [AUC] = 0.705; AUC >0.7 is acceptable). For females, the CART analysis showed that a BMI ≤36.4 is associated with a 98.4% of not demonstrating velopharyngeal CC collapse vs 30.8% for BMI >36.4 (AUC = 0.73). For females, a neck circumference ≤38.05 cm is associated with a 100% chance of not demonstrating velopharyngeal CC collapse vs 18.4% for >38.05 cm (AUC = 0.72).ConclusionThe BMI values for males and females and the female neck circumference values established by the CART model may accurately predict DISE anatomy and possible candidacy for hypoglossal nerve stimulation.
The longitudinal interplay of personality and school experiences in adolescence
Authors: Israel Anne , Brandt Naemi D , Spengler Marion , Göllner Richard , Lüdtke Oliver , Trautwein Ulrich , Wagner Jenny 
Published: January 2022

The school environment is one key developmental context that is assumed to shape individual characteristics during adolescence. However, little is known about which school experiences are central to personality change or whether school experiences and personality co-shape each other over time. We address this gap by examining the longitudinal interplay between seven school experiences in the three domains of achievement, social relationships, and well-being, and the Big Five personality traits at four measurement points from fifth to eighth grade. By using data from the German TRAIN study ( N = 3,473, MageT1 = 11.1 years, 45% female), we estimated bivariate latent growth curve models and cross-lagged panel models to illustrate this longitudinal interplay. Results demonstrated correlated change between school experiences and personality with differentiated patterns for achievement variables and a general longitudinal interplay with the social relationship and well-being variables. Furthermore, we found cross-lagged effects in both directions, although there were more effects of personality on school experiences. The most consistent predictor of school experiences was conscientiousness, whereas well-being in school in particular was related to personality change 1 year later. We integrate our findings into the current picture of personality development in adolescence and the role of school-related environmental factors.
The Influence of Palliative Care in Hospital Length of Stay and the Timing of Consultation
Authors: Davis Mellar P. , Van Enkevort Erin A. , Elder Alexander , Young Amanda , Correa Ordonez Irina D. , Wojtowicz Mark J , Ellison Halle , Fernandez Carlos , Mehta Zankhana 
Published: January 2022

Background Inpatient palliative care may reduce length-of-stay, costs, mortality, and prevent readmissions. Timing of consultation may influence outcomes. The aim of this study was to explore the timing of consultation and its influences patient outcomes. Method This retrospective study of hospital consultations between July 1, 2019 and December 31, 2019 compared patients seen within 72 hours of admission with those seen after 72 hours. Outcomes length of stay and mortality. Chi-square analyses for categorical variables and independent t-tests for continuous normally distributed variables were done. For nonparametrically distributed outcome variables, Wilcoxon rank sum test was used. For mortality, a time-to-event analysis was used. 30-day readmissions were assessed using the Fine-Gray sub-distribution hazard model. Multiple regression models were used, controlling for other variables. Results 696 patients were seen, 424 within 72 hours of admission. The average age was 73 and 50.6% were female. Consultation within 72 hours was not associated with a shorter stay for cancer but was for patients with non-cancer illnesses. Inpatient mortality and 30-days mortality were reduced but there was a higher 30-day readmission rate. Discussion Palliative consultations within 72 hours of admission was associated with lower hospital stays and inpatient mortality but increased the risk of readmission. Benefits were largely observed in patients followed in continuity. Conclusion Early inpatient palliative care consultation was associated with reduced hospital mortality, 30-day mortality and length of stay particularly if patients were seen by palliative care prior to hospitalization.
Association of Normal vs Abnormal Meary Angle With Hindfoot Malalignment and First Metatarsal Rotation: A Short Report
Authors: Steadman Jesse , Bakshi Neil , Philippi Matthew , Arena Christopher , Leake Richard , Barg Alexej , Saltzman Charles L. 
Published: January 2022

Background: Recent work has reported a significant association between first metatarsal (M1) rotation and hindfoot alignment, with the finding of a moderate association between the calcaneal moment arm (CMA) and 2 M1 pronation angular measures: Saltzman ( r = 0.641, P < .01) and Kim ( r = 0.615, P < .01). The aim of the current post hoc investigation was to determine if this association is related with Meary angle. Methods: We reanalyzed previously published data set separating patients into 2 groups: (1) those with normal Meary angle (n = 128) and (2) those with abnormal Meary angle (n = 147). Hindfoot alignment and M1 rotation were measured on weightbearing computed tomography. Statistical analyses were performed to evaluate for association between these variables among the groups. Results: The correlation between CMA and M1 rotation of the entire cohort was r = 0.577 (Saltzman ankle) and r = 0.540 (Kim angle). For the subset with a normal Meary angle, this association was negligible (Saltzman and Kim angles, r = 0.194 and 0.240, respectively). Conversely, for the abnormal Meary angle subset, the association was substantial (Saltzman and Kim angles, r = 0.733 and 0.675, respectively). Conclusion: Patients presenting with an abnormal Meary angle and hindfoot deformity have a high likelihood of manifesting a proportionate degree of M1 rotation. Level of Evidence: Level III, Retrospective Cohort Study.
Accelerating Cancer Patient Recruitment Through a Mobile Application (Clinical Trial Finder)
Authors: Mudaranthakam Dinesh Pal , Alsup Alexander M , Murakonda Vinay , Lin Tara , Thompson Jeffrey , Gajewski Byron , Mayo Matthew S 
Published: January 2022

Objective: Participant recruitment is a challenge for any clinical trial but is especially complex in cancer specifically due to the need to initiate treatment urgently. Most participants enrolled in oncology clinical trials are identified as potential participants by the oncologist or other referring provider. Optimal clinical care for patients with cancer includes consideration of participation in a clinical trial. However, the process of finding a clinical trial that is appropriate the patient can be cumbersome and time consuming. Material and Methods: The University of Kansas Cancer Center has developed a mobile application (app) which streamlines the clinical trial search process for physicians, patients, and caregivers by cohesively integrating all clinical trials currently recruiting in the center and making them easy to browse. Results: Key aspects of the app include simple filtering options, the ability to search for trials by name, easily accessible assistance, and in-app referral by phone or email. Initial feedback on the app has been very positive, with several suggestions already being implemented in future development. The app was designed to be used both by physicians to find trials, as well as patients in collaboration with their physicians. Conclusion: While long-term results will be crucial to understanding how the app can best serve our patient population, our initial results suggest that health system specific clinical trial apps can address a currently unmet need in the clinical trial recruitment process.
Hypothermically Stored Amniotic Membrane for the Treatment of Cartilage Lesions: A Single-Arm Prospective Study with 2-Year Follow-Up
Authors: Tabet Samuel K. , Kimmerling Kelly A. , Hale Galen J. , Munson Natalie R. , Mowry Katie C. 
Published: January 2022

Objective The purpose of this study was to determine the safety and efficacy of hypothermically stored amniotic membrane (HSAM) for the treatment of cartilage lesions of the knee using imaging, patient-reported outcomes (PROs), second-look arthroscopy, and histology. Patients were treated with HSAM and followed for 2 years. Design Subjects with focal chondral lesions of the femur (International Cartilage Repair Society grade 3-4) were enrolled in this single-arm prospective study. Standard of care imaging was completed. PROs, including the Knee Injury and Osteoarthritis Outcome Score (KOOS), Marx Activity Scale, and Visual Analog Scale (VAS), were collected at baseline and at 3, 6, 12, 18, and 24 months. Three subjects underwent an optional arthroscopy and biopsy of the repair at 24 months. Results Ten subjects were enrolled and completed the study. At 24 months, KOOS Sports & Recreation improved 173.3% and Quality of Life improved 195.3% from baseline. Marx Activity Scale increased 266.8% from 12 to 24 months. VAS scores improved 84.8% and 81.0% from baseline to 24 months for average and maximum pain. Modified Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) scoring showed that 7 of 10 subjects had complete defect repair and filling by 24 months. Biopsy staining for collagen II revealed integration and remodeling of HSAM into a mix of hyaline-like cartilage and fibrocartilage matrix. Conclusion This study provides evidence supporting the safety and efficacy of HSAM for treating symptomatic cartilage lesions. Subjects showed a high degree of defect fill and integration with the native cartilage and reported improvements in pain and function post-treatment. Results provide important original data for future clinical trials.
Cross Cultural Adaptation and Cognitive Testing of a Psycho-Social-Spiritual Healing Measure, the NIH Healing Experiences in All Life Stressors-NIH-HEALS
Authors: Namisango Eve , Luyirika Emmanuel B. K. , Berger Ann 
Published: January 2022

Background Cancer is associated with trauma and stress which impacts the physical, psychological, and spiritual/existential well-being of patients. Psychological/behavioral healing may help alleviate this distress and the associated health-related suffering. Psycho-Social-Spiritual healing outcome measures are thus needed to stimulate service development. The NIH Healing Experiences in All Life Stressors (NIH-HEALS), is a novel 35-item measure of psycho-social-spiritual healing, developed in USA and is yet to be validated and adapted for use in African countries. Objectives This study aimed to assess the face and content validity of the NIH-HEALS in the population of cancer patients in Uganda and to culturally adapt this measure. Methods Cross-sectional study using cognitive interviewing alongside standard piloting. We recruited adult (18 years and above) patients with advanced cancer from Hospice Africa Uganda. Interviews were conducted in two phases, using the think aloud technique and concurrent probing and were audio recorded. Phase 1 was used to identify initial concerns around clarity of the statements, and phase 2 further explored whether the issues of clarity had been addressed, alongside the standard cognitive interview parameters. The transcripts were imported into NVivo-12 analyzed using the content analysis technique and categorized using Tourengeau’s information processing model. Results We recruited thirty-five (35) patients: phase one (n = 5) two (n = 30). The median completion time was 20 minutes. Problems identified included comprehension of some statements, words, and phrases, suggestions to include local examples, highlighting of potentially sensitive statements that lean towards difficult conversations, and some cultural differences in the construction of the “Trust and Acceptance” construct, our sample showed less emphasis on family/friend relations. This feedback was used to adapt the NIH-HEALS for the local context. Conclusion The NIH-HEALS has sufficient face and content validity properties to be used among palliative cancer patients in Uganda. We propose some changes to inform the adaptation of this measure for the local context.