bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of staining beverages and bleaching on optical properties of a CAD/CAM nanohybrid and nanoceramic restorative material
Authors: Elsaka Shaymaa , Taibah Salwa , Elnaghy Amr 
Published: March 2022

Abstract
Background
The purpose of this study was to evaluate the optical properties of nanohybrid Grandio (GR) and nanoceramic Lava Ultimate (LU) CAD/CAM restorative materials subjected to different beverage solutions and subsequently bleached.

Methods
Five groups of each restorative material (n = 20/group, shade A2-high translucent) were immersed in distilled water, coffee, tea, cola, and ginger for one week. Changes in whiteness index, translucency parameter, and color changes of the specimens were evaluated. The data of color measurements after staining, bleaching, and the residual differences were statistically analyzed using Kruskal–Wallis and Mann–Whitney U tests at the significance level of P < 0.05.

Results
LU and GR revealed the highest differences in whiteness index after coffee staining (P < 0.001). GR revealed lower translucency parameter differences after staining with coffee than LU (P = 0.007). There were no significant differences in translucency changes between LU and GR after staining with tea, cola, or ginger (P > 0.05). LU revealed significantly greater color changes than GR after staining (P < 0.001).

Conclusions
LU nanoceramic CAD/CAM restorative material revealed higher color changes than GR nanohybrid material. Staining beverage solutions had a distinct influence on the optical properties of the tested CAD/CAM restorative materials.
Identifying priorities, directions and a vision for Indigenous mental health using a collaborative and consensus-based facilitation approach
Authors: Montesanti Stephanie , Fitzpatrick Kayla , Fayant Bryan , Pritchard Caillie 
Published: March 2022

Abstract
Background
Mental health disparities between Indigenous and non-Indigenous people in Canada are related to underlying economic, social, and political inequities that are legacies of colonization and the oppression of Indigenous cultures. It also widely acknowledged that mental health services currently available may not be culturally appropriate in supporting the health needs of Indigenous Canadians. A two-day Indigenous mental health forum examined mental health needs and gaps among Indigenous communities across the Regional Municipality of Wood Buffalo (RMWB) on Treaty 8 territory, in northern Alberta, Canada. This paper outlines the insights generated by stakeholder engagement at the forum to identify and prioritize directions for Indigenous mental health and build a vision and strategy for improving mental health services and programs for the region’s diverse Indigenous population.

Methods
We applied a modified nominal group technique (NGT) consensus method embedded within Indigenous knowledge to determine key priorities and directions for Indigenous-focused mental health and synthesize information from discussions that occurred at the forum. Following the NGT, a participatory community visioning exercise was conducted with participants to develop a vision, guiding principles, and components of an action plan for an Indigenous mental health strategy for the RMWB.

Results
Four key themes for setting priorities and directions for Indigenous mental health emerged from roundtable group discussions: 1) understand the realities of mental health experiences for Indigenous peoples, 2) design a holistic and culturally rooted mental health system, 3) foster cross-sectoral engagement and collaboration on mental health service delivery, and 4) focus on children and youth. The community visioning exercise helped stakeholders to visualize a direction or path forward for addressing existing gaps in the mental health system and opportunities for strengthening Indigenous mental health in the region.

Conclusions
Forum participants described mental health and well-being around holistic concepts of social and emotional well-being. Addressing Indigenous mental health and wellness involves multi-sectoral action in various settings including community and school through programs, policies, and other interventions that promote mental health for all Indigenous peoples, as well as for those at greater risk such as children and youth.
Metabolic characteristics and prognostic differentiation of aggressive lymphoma using one-month post-CAR-T FDG PET/CT
Authors: Breen William G. , Hathcock Matthew A. , Young Jason R. , Kowalchuk Roman O. , Bansal Radhika , Khurana Arushi , Bennani N. Nora , Paludo Jonas , Villasboas Bisneto Jose C. , Wang Yucai , Ansell Stephen M. , Peterson Jennifer L. , Johnston Patrick B. , Lester Scott C. , Lin Yi 
Published: March 2022

Abstract
Background
F-18 fluorodeoxyglucose positron emission tomography computed tomography (PET/CT) is used to assess response of non-Hodgkin lymphoma (NHL) to chimeric antigen receptor T cell (CAR-T) therapy. We sought to describe metabolic and volumetric PET prognostic factors at one month post-CAR-T and identify which patients with partial response (PR) or stable disease (SD) are most likely to subsequently achieve complete response (CR), and which will develop progressive disease (PD) and death.

Methods
Sixty-nine patients with NHL received axicabtagene ciloleucel CAR-T therapy. One-month post-CAR-T infusion and PET/CT scans were segmented with a fixed absolute SUV maximum (SUVMax) threshold of 2.5 using a semiautomated workflow with manual modification to exclude physiologic uptake as needed. Metabolic tumor volume (MTV), total lesion glycolysis (TLG), SUVMax, and other lesion characteristics were calculated and associated with risk of PD and death.

Results
Patients with total MTV > 180 cc, presence of bone or parenchymal disease, SUVMax > 10, single lesion TLG > 245 g, or > 2 total lesions had increased risk of death. Patients with total MTV > 55 cc, total TLG > 250 cc, SUV Max > 10, or > 2 total lesions had increased risk of PD. For the subset of 28 patients with PR/SD, higher SUVMax was associated with increased risk of subsequent PD and death. While 86% of patients who had SUVMax ≥ 10 eventually had PD (HR 3.63, 1.13–11.66, p = 0.03), only 36% of those with SUVMax < 10 had PD.

Conclusions
Higher SUVMax at one month post-CAR-T is associated with higher risk of PD and death. SUVMax ≥ 10 may be useful in guiding early salvage treatment decisions in patients with SD/PR at one month.
Management of severe neonatal respiratory distress due to vertical transmission of severe acute respiratory syndrome coronavirus 2: a case report
Authors: Verheijen Anne C. , Janssen Eva E. R. , van der Putten Mayke E. , van Horck Marieke W. P. , van Well Gijs T. J. , Van Loo Inge H. M. , Hütten Matthias C. , Van Mechelen Karen 
Published: March 2022

Abstract
Background
Neonates with severe acute respiratory syndrome coronavirus 2 infection are usually asymptomatic or have mild to moderate symptoms. Acute respiratory distress syndrome due to severe acute respiratory syndrome coronavirus 2 with respiratory insufficiency is rare. Therefore, information about the best intensive care strategy for neonates requiring mechanical ventilation is lacking. We report a neonatal case of severe acute respiratory distress syndrome, probably due to vertical transmission of severe acute respiratory syndrome coronavirus 2, complicated by Staphylococcus aureus sepsis. We aim to inform pediatric providers on the clinical course and acute management considerations in coronavirus disease-related neonatal acute respiratory distress syndrome.

Case presentation
A late preterm (gestational age 36 0/7 weeks) Caucasian girl was born from a severe acute respiratory syndrome coronavirus 2-positive mother and tested positive for severe acute respiratory syndrome coronavirus 2 at 19 hours after birth. She developed acute respiratory distress syndrome requiring intensive care admission and mechanical ventilation. The clinical course was complicated by S. aureus pneumonia and bacteremia. Multimodal management included well-established interventions for respiratory distress syndrome such as surfactant therapy, high-frequency oscillatory ventilation, and inhaled nitric oxide, combined with therapies extrapolated from adult care for severe acute respiratory syndrome coronavirus 2 patients such as dexamethasone, coronavirus disease 2019-specific immunoglobins, and prophylactic low-molecular-weight heparin. The neonate was successfully weaned from the ventilator and improved clinically.

Conclusion
This case shows a rare but serious neonatal severe acute respiratory syndrome coronavirus 2 infection, leading to severe acute respiratory distress syndrome. Because of limited therapy guidelines for neonates, we suggest multimodal management with awareness of the possibility of S. aureus coinfection, to treat this age group successful.
Creating an Agricultural World Order: Regional Plant Protection Problems and International Phytopathology, 1878–1939
Authors: CASTONGUAY STÉPHANE 
Published: March 2022

Abstract
Beginning in 1878 with the International Phylloxera Convention of Berne, international conventions have sought to relieve national agricultural industries from two specific burdens. First, by defining phytosanitary practices to be enforced by national plant protection services, these conventions attempted to prevent the introduction of plant diseases and pests into national territories from which they were previously absent. Second, by standardizing these practices—especially through the design of a unique certificate of inspection—the conventions attempted to eliminate barriers such as quarantines affecting international agricultural trade. The succession of phytopathological conventions seemed to epitomize the coalescence of an international community against agricultural pests. What actually coalesced was bio-geopolitics wherein plant pathologists and economic entomologists from North America and the British Empire questioned the so-called internationality of the environmental and economic specificities of continental European agriculture, embodied in "international" conventions. Although an international phenomenon, the dissemination of agricultural pests provided opportunities for cooperation on a strictly regional albeit transnational basis that pitted bio-geopolitical spaces against each other. This article retraces the formation of these spaces by analyzing the deliberations of committees and congresses that gathered to define an international agricultural order based on the means to prevent the spread of plant disease and pests.
Study trends on Resilience of Nursing Students -Focusing on nursing journals published in South Korea-
Authors: Kang Se-Won 
Published: March 2022

This study is a literature review to understand the trends in the nursing students’ resilience published in nursing journals in South Korea. Among the papers published in nursing journals in South Korea, the research papers included “resilience” and “nursing students.”
As a result of the search, 40 papers suitable for literature review, which included three experimental studies and 37 descriptive studies, were selected for relational and factor analysis. The most frequently used variables along with resilience were self-esteem, self-leadership, depression, and emotional intelligence. In the future, intervention studies to strengthen the resilience of nursing students should be conducted.
Global Assets Mitigate Global Inflation
Authors: Bechtel Gordon 
Published: March 2022

This article finds that 26 global assets mitigate global inflation. Fractional polynomial regressions return sizable goodness-of-fit R2s for these assets, along with high mitigating Pearson correlations between these assets and global inflation. It is hoped that future fractional polynomial regressions will reveal other global assets that also mitigate global inflation. In view of Russia's invasion of the Ukraine, which preempted American President Biden's State of the Union address (Aljazeera, March 1 2022), and the trade war between the United States and China, the United Nations has now stepped in to protect it's member states from the interest-rate and inflationarity effects wrought by these three super powers.
Die Re-Regulierung der Schlachthofarbeit in der Corona-Krise
Authors: Sebastian Marcel , Seeliger Martin 
Published: March 2022

Zusammenfassung
Die prekären Arbeits- und Beschäftigungsbedingungen in der Fleischindustrie sind seit geraumer Zeit Gegenstand von Regulierungsversuchen. Eine dreifache Krise – der europäischen Integration, der Arbeitsbeziehungen und der Naturverhältnisse – zog in der Vergangenheit jedoch keine substanzielle Regulierung nach sich. Unser Artikel zeigt, dass die pandemiebedingte Ausweitung der Konsequenzen auf Betroffene außerhalb der Fleischindustrie (etwa Anrainer:innen von Schlachthöfen) die Relevanz und den Handlungsdruck erheblich erhöht hat. Auch die symbolische Relevanz des Themas stieg im Zuge der Corona-Krise, weil die Regulierungen im Zusammenhang mit der Pandemiebekämpfung der Bundesregierung insgesamt gedeutet wurden. Unsere These lautet, dass sich die bemerkenswerte Geschwindigkeit der Re-Regulierung nur auf Basis der vorgängigen, dreifachen Krisendynamik der Fleischproduktion erklären lässt. Die Analyse des Policy-Wandels hat ergeben, dass die Debatte um Arbeit und Beschäftigung in der Fleischindustrie bereits seit 2007 geführt wird. Zögerliche Regulierungsversuche sahen zwar bereits 2014 einen branchenweiten Mindestlohn vor, der jedoch großflächig unterwandert wurde. Ob die neuen Regulierungen der Bundesregierung dies nun verhindern können, indem sie Leiharbeit und Werkverträge schrittweise verboten, bleibt abzuwarten.
Increased anxiety symptoms in pediatric type 1 diabetes during the acute phase of COVID-19 lockdown
Authors: Wade Caroline , Burton Elvin Thomaseo , Akinseye Leah , Nelson Grace , Smith-Young Jamila , Kim Ahlee 
Published: March 2022

Abstract

Objectives
The prevalence of mental health issues has increased at an alarming rate during the COVID-19 pandemic. Furthermore, an exacerbated psychosocial burden in populations with chronic disease is observed. This cross-sectional study evaluated the psychosocial factors of pediatric type 1 diabetes (T1D) during the COVID-19 pandemic.

Methods
During April 2020, 15 min phone interviews were performed for pediatric T1D group (n=100) and healthy comparison group (n=93) to assess psychosocial functioning during the acute lockdown phase of the pandemic. The patient health questionnaire-4 was utilized to assess anxiety and depressive symptoms. An additional questionnaire to assess specific concerns related to T1D and COVID-19 was administered to the T1D group to explore potential causes for increased psychosocial burden.

Results
T1D was associated with a five-times higher risk of anxiety symptoms. Increased anxiety symptoms in T1D group appear to be, at least in part, due to fear of higher risk of severe COVID-19 infection and uncertainty regarding access to diabetes supplies.

Conclusions
This study provides a snapshot of mental well-being in a diverse population of patients with T1D in the acute phase of a crisis and underscores the need for timely, accurate medical information and distribution of medical resources for pediatric T1D population.
Kreditgenossenschaften: Marktstruktur, Wettbewerb und Verhalten. Das Beispiel Paraguay
Authors: Schneider Andreas 
Published: March 2022

ZusammenfassungKonzentrations- und Wettbewerbsmaße im Finanzsektor sind wichtig, um die öffentliche Politik zu orientieren. Genossenschaften, insbesondere im Kontext kleiner Entwicklungsländer, werden in der Wirtschaftsliteratur jedoch weitgehend ignoriert. Die empirische Analyse ist aufgrund der Datenverfügbarkeit deskriptiv und analysiert den Kreditmarkt großer Kreditgenossenschaften. Wir nutzen hierfür eine gepaarte Stichprobe, ausgewählt nach dem Konzentrationsprinzip, für die wir statische Konzentrationsmaße berechnen. Trotz der nicht repräsentativen Datenlage sind die Ergebnisse indikativ und bieten einen ersten Ausgangspunkt für Institutionen und Genossenschaften. Die Ergebnisse zeigen, dass die Kreditvergabe innerhalb des Genossenschaftssystems im Allgemeinen stark konzentriert ist und der Kreditmarkt praktisch in den Händen von zwei Genossenschaften liegt. Die Beteiligung kleiner Genossenschaften ist auf einen unbedeutenden Wert gesunken. Es scheint, dass die Marktkonzentration mit einer kontinuierlichen internen Migration zusammenhängt. Der Kreditmarkt großer Finanzgenossenschaften ist insgesamt nicht konzentriert, die meisten Kreditmodalitäten sind jedoch stark konzentriert, einige sind wettbewerbsfähig, andere nicht. Es gibt keine Hinweise auf einen Marktmissbrauch der drei größten Kreditgenossenschaften.
Ameloblastoma uniquístico: reporte de caso en una niña de 9 años
Authors: Balmaceda Rivera Paula , Utria Acevedo Iliany , López Aparicio Erich , Harris Ricardo Jonathan 
Published: March 2022

El ameloblastoma uniquístico es un tumor odontogénico benigno, que representa menos de un tercio de todos los ameloblastomas, comúnmente se le encuentra en la mandíbula, es el menos agresivo que otros tipos de ameloblastoma y se presenta inusualmente en niños. Se reporta caso de ameloblastoma uniquístico en una niña de 9 años, localizado en la región anterior de la mandíbula y de gran tamaño, se describen las características de la patología, tratamiento quirúrgico conservador y controles postquirúrgicos.
Performance Analysis of SSK Modulation using multipath with multihop DF relay over Nakagami-m fading channel
Authors: RAMESH JUTTU , Sudha V 
Published: March 2022

Abstract
The data transfer between devices should be prominent in the future generations for Internet of Things (IoT) applications. IoT systems need a sophisticated communication setup with less hardware and complexity. Space Shift Keying (SSK) modulation is the perfect scheme to fulfill IoT system requirements by activating a single antenna. Moreover, Cooperative communication has more reliability in point-to-point communication by the relaying system. Thus, end-to-end Bit Error Rate (BER) in the multi-hop multi-branch relaying model under cooperative communication scenario using SSK modulation scheme for IoT systems is analyzed. The closed-form expression for BER is derived over Nakagami-m fading channels and the results are verified with Monte Carlo simulation.
Comprehensive bioinformatic analysis of the expression and prognostic significance of TSC22D domain family genes in acute myeloid leukemia
Authors: Xu XiaoQiang , Jin Xin , Wang JiaXi , Sun Rui , Zhang Meng , Xiong Xia , Xie DanNi , Zhao MingFeng 
Published: March 2022

Abstract
Background:TSC22D domain family genes, including TSC22D1-4, have been extensively reported to be involved in tumors. However, their expression profiles and prognostic significance in acute myeloid leukemia (AML) remain unknown.Methods:The present study investigated the expression profiles and prognostic significance of TSC22D domain family genes in AML through the use of multiple online databases, including the CCLE, EMBL-EBI, HPA, Oncomine,GEPIA2, UALCAN, BloodSpot, and GSCALite databases. The cBioPortal and GSCALite databases were used to explore the genetic alteration and copy number variation (CNV) of TSC22D3. TRRUST Version 2 was used to explore the gene ontology biological process, disease ontology, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with TSC22D3. The AnimalTFDB3.0, STRING, and Harmonizome databases were used to investigate the protein–protein interaction (PPI) network of TSC22D3. Harmonizome was used for TSC22D gene regulatory kinase analysis. The TargetScanHuman 8.0, MiRDB, and ENCORI databases were used to execute the analysis of TSC22D3 regulatory miRNAs. Then, the GSCALite and GEPIA2021 databases were used to investigate the correlation between TSC22D3 expression and immune infiltration.Results:The expression of TSC22D3 was upregulated markedly in AML cells relative to normal hematopoietic stem cells. The expression of TSC22D3 was increased in AML group compared with normal control group. And overexpression of TSC22D3 was associated with poor OS in AML patients.Furthermore, gene ontology analysis revealed that TSC22D3 was involved in leukemia. Functional enrichment analysis indicated that TSC22D3 has many biological functions, including the regulation of many genes, kinases, miRNAs, signaling pathways, and immune infiltration.Conclusions:TSC22D3 expression was upregulated in AML, and overexpression was associated with poor OS in AML patients. Therefore, TSC22D3 may serve as a novel prognostic biomarker for AML.
Establishing the Taxa with Phylogenetic profile and in-silico-ayurvedic remedy of Microbiome of Bacterial Vaginosis
Authors: Geethashree S , Bagchi Preenon , Murthy Shylesh 
Published: March 2022

Abstract
Background: Bacterial vaginosis (BV) is a vaginal disease commonly caused by bacteria which most commonly causes abnormal vaginal discharge during women’s reproductive-age. BV is characterized by a shift within the vaginal flora from the dominant Lactobacillus to a polymicrobial flora and is further characterized by depletion of the resident lactic-acid-producing Lactobacillus spp. BV has been associated with serious health issues, including pelvic inflammatory disease and increased susceptibility to sexually transmitted diseases (STD) but itself is not a STD. Several genes and chromosomal regions have been found to be associated with BV in various linkage analyses, case-control studies, genome-wide association studies (GWAS), and admixture mapping studies.Methods: In this work, using BV microbiome we perform metagenome analysis which enables us to understand how the microbiome responds to the host by studying the functional analysis of genes expressed. The technology is used to determine the order of nucleotides or targeted regions of DNA or RNA. Krona pie chart is used for visualization of the taxonomy. Results: HUMAnN2 tool is used to determine the pathways and their abundance file of microbiome. Further, homology modelling of the BV gene receptors, Leucine Aminopeptidase 3 (LAP3) and Peptidase D (PEPD) was done and ligands from ayurvedic medicinal herbs were established. Conclusion: The taxonomy and functional information of BV microbiome are identified.
Preoperative prediction of sagittal imbalance in kyphosis secondary to ankylosing spondylitis after one-level three-column osteotomy
Authors: luo jianzhou , yang kai , yang zili , duan chunguang , chen jiayi , huang zhengji , luo zhenjuan , tao huiren , wu tailin 
Published: March 2022

Abstract
Background: This study aimed to determine preoperative predictions of sagittal imbalance in kyphosis secondary to ankylosing spondylitis (AS) after one-level three-column osteotomy. Methods: A total of 55 patients with AS who underwent one-level three-column osteotomy were enrolled. The patients were divided into two groups according to sagittal vertical axis (SVA) value at the final follow-up (group A: SVA>5 cm; group B: SVA≤5 cm). The radiographic measurements were measured, including global kyphosis, lumbar lordosis (LL), pelvic tilt (PT), pelvic incidence (PI), sacral slope, T1 pelvic angle (TPA), SVA, osteotomized vertebral angle and PI and LL mismatch (PI-LL). Results: Fifty-five AS patients were followed up for 30.6 ± 10.2 months averagely (range, 24–84 months). Preoperatively and postoperatively, group A had larger LL, PT, PI - LL, TPA, and SVA values than group B (P<0.05). And the preoperative LL, PT, PI - LL, TPA, and SVA values had significantly positive relationships with the follow-up SVA value (P<0.05). The preoperative TPA>40.9°, PI-LL>32.5°, and SVA>13.7 cm were the top three predictions with the best accuracy to predict sagittal imbalance. The construction of postoperative SVA<7.4 cm was the key factor for decreasing the chance of sagittal imbalance on follow-up. Conclusions: The preoperative TPA>40.9°, PI - LL>32.5°, and SVA>13.7 cm could predict sagittal imbalance for AS kyphosis after one-level three-column osteotomy, and additional osteotomies were recommended for this condition. The postoperative SVA<7.4 cm was an optimal alignment for preventing sagittal imbalance. Level of evidence: IV