bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modern concepts and biomarkers of blood stasis in cardio- and cerebrovascular diseases from the perspectives of Eastern and Western medicine: a scoping review protocol
Authors: Park Miso S. , Kim Jihye , Kim Keun Ho , Yoo Ho-Ryong , Chae Incheol , Lee Juho , Joo In Hwan , Kim Dong Hee 
Published: August 2022

Objective:
The objective of this review is to provide a modern definition and identify potential biomarkers of blood stasis in cardio- and cerebrovascular diseases by mapping, comparing, and combining Eastern and Western concepts.

Introduction:
Blood stasis is a pathological concept found in both Eastern and Western medical literature. In traditional East Asian medicine, blood stasis is a differential syndrome characterized by stagnant blood flow in various parts of the body. Similarly, in Western medicine, various diseases, especially cardio- and cerebrovascular diseases, are known to be accompanied by blood stasis. Numerous scientific studies on blood stasis have been conducted over the last decade, and there is a need to synthesize those results.

Inclusion criteria:
We will use the keywords “blood stasis,” “blood stagnation,” “blood stagnant,” and “blood congestion” in 3 electronic databases: PubMed, Cochrane CENTRAL, and Google Scholar. In addition, we will use the keywords “어혈” and “혈어” in 4 Korean electronic databases (ie, NDSL, OASIS, KISS, and DBpia). Peer-reviewed articles published from 2010 to the present that focus on blood stasis in cardio- and cerebrovascular diseases in human subjects according to the International Classification of Diseases 11th revision categories BA00-BE2Z, 8B00-8B2Z, 8E64, and 8E65 will be included. Reviews, opinion articles, in vivo, in vitro, and in silico preclinical studies will be excluded.

Methods:
We will follow the frameworks by Arksey and O’Malley and Levac et al. as well as JBI guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews. Two reviewers will independently search and screen titles and abstracts followed by full-text screening of eligible studies. If there are discrepancies between the 2 reviewers, a third reviewer will be consulted to make the final decision. We will use descriptive narrative, tabular, and graphical displays, and content analysis to present the results.

Scoping review registration:
Open Science Framework https://osf.io/gv4ym
Hábitat e infancias, derechos pendientes e inequidades en Latinoamérica
Authors: Tuñon Ianina , Aguado Quintero Luis Fernando , Vera Cossío Horacio , Osorio Mejía Ana María 
Published: August 2022

Los Objetivos de Desarrollo Sostenible (ODS) de 2015 establecen como meta al 2030 “asegurar el acceso de todas las personas a viviendas y servicios básicos adecuados, seguros y asequibles y mejorar los barrios marginales”, además de “garantizar la disponibilidad de agua y su gestión sostenible y el saneamiento para todos”.
Se propone reflexionar y construir evidencia longitudinal para diferentes países de Latinoamérica en torno a la particular vulnerabilidad de las infancias a las condiciones deficitarias de su medio ambiente. Para la construcción de los datos se utilizan las encuestas de hogares de los países miembros de la Red Odsal: Argentina, Bolivia, Colombia, Brasil, Chile, Perú y México, en los periodos de tiempo 2002-03, 2010-11 y 2017.
El hábitat de vida tóxico, el medioambiente insalubre y el hacinamiento aumentan la propensión de algunas infancias a padecer enfermedades crónicas tempranamente, representando un obstáculo para la formación educativa y el desarrollo de las capacidades de sociabilidad
Estilos y paradigmas evaluativos en docentes de educación escolar
Authors: Ríos-Muñoz Daniel , Herrera-Araya David , Salinas-Fritz Paulina 
Published: August 2022

Este trabajo tiene por objetivo establecer los estilos evaluativos y describir sus características con respecto a los paradigmas de evaluación en docentes escolares de Santiago de Chile, Chile. La investigación utilizó un enfoque mixto. Se aplicaron un cuestionario y una entrevista grupal, según el modelo de estilos evaluadores de 54 docentes de tres escuelas. Los resultados señalan que los docentes combinan estilos evaluativos analítico-formalista y tolerante-orientador, lo cual se relaciona con una integración de paradigma positivista y naturalista de evaluación. En conclusión, los hallazgos señalan tensiones en los docentes para enfrentar las exigencias estandarizadas con las perspectivas auténticas de evaluación.
Covid-19 vaccination in pregnancy
Authors: Badell Martina L , Dude Carolynn M , Rasmussen Sonja A , Jamieson Denise J 
Published: August 2022

ABSTRACTPregnancy is an independent risk factor for severe covid-19. Vaccination is the best way to reduce the risk for SARS-CoV-2 infection and limit its morbidity and mortality. The current recommendations from the World Health Organization, Centers for Disease Control and Prevention, and professional organizations are for pregnant, postpartum, and lactating women to receive covid-19 vaccination. Pregnancy specific considerations involve potential effects of vaccination on fetal development, placental transfer of antibodies, and safety of maternal vaccination. Although pregnancy was an exclusion criterion in initial clinical trials of covid-19 vaccines, observational data have been rapidly accumulating and thus far confirm that the benefits of vaccination outweigh the potential risks. This review examines the evidence supporting the effectiveness, immunogenicity, placental transfer, side effects, and perinatal outcomes of maternal covid-19 vaccination. Additionally, it describes factors associated with vaccine hesitancy in pregnancy. Overall, studies monitoring people who have received covid-19 vaccines during pregnancy have not identified any pregnancy specific safety concerns. Additional information on non-mRNA vaccines, vaccination early in pregnancy, and longer term outcomes in infants are needed. To collect this information, vaccination during pregnancy must be prioritized in vaccine research.
Machine-learning algorithm to non-invasively detect diabetes and pre-diabetes from electrocardiogram
Authors: Kulkarni Anoop R , Patel Ashwini A , Pipal Kanchan V , Jaiswal Sujeet G , Jaisinghani Manisha T , Thulkar Vidya , Gajbhiye Lumbini , Gondane Preeti , Patel Archana B , Mamtani Manju , Kulkarni Hemant 
Published: August 2022

ObjectivesEarly detection is of crucial importance for prevention of type 2 diabetes and pre-diabetes. Diagnosis of these conditions relies on the oral glucose tolerance test and haemoglobin A1c estimation which are invasive and challenging for large-scale screening. We aimed to combine the non-invasive nature of ECG with the power of machine learning to detect diabetes and pre-diabetes.MethodsData for this study come from Diabetes in Sindhi Families in Nagpur study of ethnically endogenous Sindhi population from central India. Final dataset included clinical data from 1262 individuals and 10 461 time-aligned heartbeats recorded digitally. The dataset was split into a training set, a validation set and independent test set (8892, 523 and 1046 beats, respectively). The ECG recordings were processed with median filtering, band-pass filtering and standard scaling. Minority oversampling was undertaken to balance the training dataset before initiation of training. Extreme gradient boosting (XGBoost) was used to train the classifier that used the signal-processed ECG as input and predicted the membership to ‘no diabetes’, pre-diabetes or type 2 diabetes classes (defined according to American Diabetes Association criteria).ResultsPrevalence of type 2 diabetes and pre-diabetes was ~30% and ~14%, respectively. Training was smooth and quick (convergence achieved within 40 epochs). In the independent test set, the DiaBeats algorithm predicted the classes with 97.1% precision, 96.2% recall, 96.8% accuracy and 96.6% F1 score. The calibrated model had a low calibration error (0.06). The feature importance maps indicated that leads III, augmented Vector Left (aVL), V4, V5 and V6 were most contributory to the classification performance. The predictions matched the clinical expectations based on the biological mechanisms of cardiac involvement in diabetes.ConclusionsMachine-learning-based DiaBeats algorithm using ECG signal data accurately predicted diabetes-related classes. This algorithm can help in early detection of diabetes and pre-diabetes after robust validation in external datasets.
Different AT(N) profiles and clinical progression classified by two different N markers using total tau and neurofilament light chain in cerebrospinal fluid
Authors: Kasuga Kensaku , Kikuchi Masataka , Tsukie Tamao , Suzuki Kazushi , Ihara Ryoko , Iwata Atsushi , Hara Norikazu , Miyashita Akinori , Kuwano Ryozo , Iwatsubo Takeshi , Ikeuchi Takeshi 
Published: August 2022

BackgroundThe AT(N) classification was proposed for categorising individuals according to biomarkers. However, AT(N) profiles may vary depending on the markers chosen and the target population.MethodsWe stratified 177 individuals who participated in the Japanese Alzheimer’s Disease Neuroimaging Initiative by AT(N) classification according to cerebrospinal fluid (CSF) biomarkers. We compared the frequency of AT(N) profiles between the classification using total tau and neurofilament light chain (NfL) as N markers (AT(N)tauand AT(N)NfL). Baseline characteristics, and longitudinal biological and clinical changes were examined between AT(N) profiles.ResultsWe found that 9% of cognitively unimpaired subjects, 49% of subjects with mild cognitive impairment, and 61% of patients with Alzheimer’s disease (AD) dementia had the biological AD profile (ie, A+T+) in the cohort. The frequency of AT(N) profiles substantially differed between the AT(N)tauand AT(N)NfLclassifications. When we used t-tau as the N marker (AT(N)tau), those who had T− were more frequently assigned to (N)−, whereas those who had T+were more frequently assigned to (N)+ than when we used NfL as the N marker (AT(N)NfL). During a follow-up, the AD continuum group progressed clinically and biologically compared with the normal biomarker group in both the AT(N)tauand AT(N)NfLclassifications. More frequent conversion to dementia was observed in the non-AD pathological change group in the AT(N)tauclassification, but not in the AT(N)NfLclassification.ConclusionsAT(N)tauand AT(N)NfLin CSF may capture different aspects of neurodegeneration and provide a different prognostic value. The AT(N) classification aids in understanding the AD continuum biology in various populations.
Proxy-reported experiences of palliative, non-operative management of geriatric patients after a hip fracture: a qualitative study
Authors: Nijdam Thomas Marcus Paulus , Laane Duco Willem Pieter Marie , Spierings Jelle Friso , Schuijt Henk Jan , Smeeing Diederik Pieter Johan , van der Velde Detlef 
Published: August 2022

ObjectiveThe objective of this study was to explore the experiences from the period after the choice was made for palliative, non-operative management for geriatric patients with a hip fracture, to the most important factors in the process, as reported by a proxy.DesignSemistructured interviews were conducted between 1 August 2020 and 1 April 2021 to investigate by-proxy reported patient experiences of non-operative management after hip fracture. Interviews followed a topic guide, recorded and transcribed per word. Thematic analysis was used to identify themes in the data.Setting and participantsPatients were retrospectively identified from the electronic patient record. Relatives (proxies) of the patients who underwent palliative, non-operative management were contacted and were asked to participate in a semistructured interview and were named participants. The participants were proxies of the patients since patients were expected to be deceased during the timing of the interview.ResultsA total of 26 patients were considered eligible for inclusion in this study. The median age of the patients was 88 years (IQR 83–94). The 90-day mortality rate was 92.3%, with a median palliative care period of 11 days (IQR 4–26). A total of 19 participants were subjected to the interview. After thematic analysis, four recurring themes were identified: (1) the decision-making process, (2) pain experience, (3) patient–relative interaction and (4) the active dying.ConclusionsWith the introduction of shared decision-making in an acute setting for geriatric patients with hip fracture, proxies reported palliative, non-operative management as an acceptable and adequate option for patients with high risk of adverse outcomes after surgery. The emerged themes in palliative care for patients with hip fracture show great similarity with severe end-stage disease palliative care, with pain identified as the most important factor influencing comfort of the patient and their environment after hip fracture. Future research should focus on further improving targeted analgesia for these patients focusing on acute pain caused by the fracture.
Time-efficient physical activity intervention for older adolescents with disability: rationale and study protocol for the Burn 2 Learn adapted (B2La) cluster randomised controlled trial
Authors: Kable Toby J , Leahy Angus A , Smith Jordan J , Eather Narelle , Shields Nora , Noetel Michael , Lonsdale Chris , Hillman Charles H , Reeves Penny , Oldmeadow Christopher , Kennedy Sarah G , Boyer James , Stimpson Leisl , Comis Pierre , Roche Laura , Lubans David R 
Published: August 2022

IntroductionPhysical activity declines during adolescence, with the lowest levels of activity observed among those with disability. Schools are ideal settings to address this issue; however, few school-based interventions have been specifically designed for older adolescents with disability. Our aim is to investigate the effects of a school-based physical activity programme, involving high-intensity interval training (HIIT), on physical, mental and cognitive health in older adolescents with disability.Methods and analysisWe will evaluate the Burn 2 Learn adapted (B2La) intervention using a two-arm, parallel group, cluster randomised controlled trial with allocation occurring at the school level (treatment or waitlist control). Secondary schools will be recruited in two cohorts from New South Wales, Australia. We will aim to recruit 300 older adolescents (aged 15–19 years) with disability from 30 secondary schools (10 in cohort 1 and 20 in cohort 2). Schools allocated to the intervention group will deliver two HIIT sessions per week during scheduled specialist support classes. The sessions will include foundational aerobic and muscle strengthening exercises tailored to meet student needs. We will provide teachers with training, resources, and support to facilitate the delivery of the B2La programme. Study outcomes will be assessed at baseline, 6 months (primary endpoint), and 9 months. Our primary outcome is functional capacity assessed using the 6 min walk/push test. Secondary outcomes include physical activity, muscular fitness, body composition, cognitive function, quality of life, physical literacy, and on-task behaviour in the classroom. We will also conduct economic and process evaluations to determine cost-effectiveness, programme acceptability, implementation, adaptability, and sustainability in schools.Ethics and disseminationThis study has received approval from the University of Newcastle (H-2021–0262) and the New South Wales Department of Education (SERAP: 2021257) human research ethics committees. Findings will be published in peer-reviewed journals, and key stakeholders will be provided with a detailed report following the study.Trial registration numberAustralian New Zealand Clinical Trials Registry Number: ACTRN12621000884808.
Angular coefficients in $$\hbox {W}+\hbox {j}$$ production at the LHC with high precision
Authors: Pellen Mathieu , Poncelet Rene , Popescu Andrei , Vitos Timea 
Published: August 2022

AbstractThe extraction of the W-boson mass, a fundamental parameter of the Standard Model, from hadron-hadron collision requires precise theory predictions. In this regard, angular coefficients are crucial to model the dynamics of W-boson production. In this work, we provide, for the first time, angular coefficients at NNLO QCD + NLO EW accuracy for finite transverse momentum W-boson at the LHC. The corrections can reach up to $$10\%$$

10
%

in certain regions of phase space. They are accompanied by a significant reduction of the scale uncertainty. This work should, besides providing reference values for theory-data comparison, provide state-of-the-art theory input for W-boson mass measurements.
Radiopurity of a kg-scale PbWO$$_4$$ cryogenic detector produced from archaeological Pb for the RES-NOVA experiment
Authors:   The RES-NOVA Group of Interest, Beeman J. W. , Benato G. , Bucci C. , Canonica L. , Carniti P. , Celi E. , Clemenza M. , D’Addabbo A. , Danevich F. A. , Di Domizio S. , DiLorenzo S. , Dubovik O. M. , Ferreiro Iachellini N. , Ferroni F. , Fiorini E. , Fu S. , Garai A. , Ghislandi S. , Gironi L. , Gorla P. , Gotti C. , Guillaumon P. V. , Helis D. L. , Kovtun G. P. , Mancuso M. , Marini L. , Olmi M. , Pagnanini L. , Pattavina L. , Pessina G. , Petricca F. , Pirro S. , Pozzi S. , Puiu A. , Quitadamo S. , Rothe J. , Scherban A. P. , Schönert S. , Solopikhin D. A. , Strauss R. , Tarabini E. , Tretyak V. I. , Tupitsyna I. A. , Wagner V. 
Published: August 2022

AbstractRES-NOVA is a newly proposed experiment for detecting neutrinos from astrophysical sources, mainly Supernovae, using an array of cryogenic detectors made of PbWO$$_4$$

4

crystals produced from archaeological Pb. This unconventional material, characterized by intrinsic high radiopurity, enables low-background levels in the region of interest for the neutrino detection via Coherent Elastic neutrino-Nucleus Scattering (CE$$\nu $$
ν
NS). This signal lies at the detector energy threshold, O(1 keV), and it is expected to be hidden by naturally occurring radioactive contaminants of the crystal absorber. Here, we present the results of a radiopurity assay on a 0.84 kg PbWO$$_4$$

4

crystal produced from archaeological Pb operated as a cryogenic detector. The crystal internal radioactive contaminations are: $$^{232}$$

232

Th <40 $$\upmu $$
μ
Bq/kg, $$^{238}$$

238

U <30 $$\upmu $$
μ
Bq/kg, $$^{226}$$

226

Ra 1.3 mBq/kg and $$^{210}$$

210

Pb 22.5 mBq/kg. We also present a background projection for the final experiment and possible mitigation strategies for further background suppression. The achieved results demonstrate the feasibility of realizing this new class of detectors.
Criticality-related fundamental bases for new generations of gas–liquid, liquid–liquid, and liquid (LE) extraction technologies
Authors: Rzoska Sylwester J. , Drozd-Rzoska Aleksandra 
Published: August 2022

Abstract
The report presents experimental results, which can be considered as the reference for innovative generations of supercritical fluids (SCF), liquid–liquid (LL), and liquid (L) extraction technologies. They are related to implementations of Critical Phenomena Physics, for such applications not considered so far. For the gas–liquid critical point, the shift SuperCritical Fluids (SCF) ⇒ SubCritical Fluids, due to the additional exogenic impact of ultrasounds, is indicated. For LL technology, the possibility of increasing process effectiveness when operating near the critical consolute under pressure is indicated. Finally, the discovery of long-range precritical-type changes of dielectric constant in linseed oil, standing even 50 K above the melting temperature, is presented. It suggests that extraction processes linking ‘SCF’ and ‘L’ technologies features and exploring the natural carrier, such as linseed oil, are possible. The report recalls the fundamental base for extraction processes via Kirkwood and Noyes–Whitney relations and presents their implementations to ‘critical conditions,’ including pressure.

Graphical abstract
Semiconductor-based electron flying qubits: review on recent progress accelerated by numerical modelling
Authors: Edlbauer Hermann , Wang Junliang , Crozes Thierry , Perrier Pierre , Ouacel Seddik , Geffroy Clément , Georgiou Giorgos , Chatzikyriakou Eleni , Lacerda-Santos Antonio , Waintal Xavier , Glattli D. Christian , Roulleau Preden , Nath Jayshankar , Kataoka Masaya , Splettstoesser Janine , Acciai Matteo , da Silva Figueira Maria Cecilia , Öztas Kemal , Trellakis Alex , Grange Thomas , Yevtushenko Oleg M. , Birner Stefan , Bäuerle Christopher 
Published: August 2022

AbstractThe progress of charge manipulation in semiconductor-based nanoscale devices opened up a novel route to realise a flying qubit with a single electron. In the present review, we introduce the concept of these electron flying qubits, discuss their most promising realisations and show how numerical simulations are applicable to accelerate experimental development cycles. Addressing the technological challenges of flying qubits that are currently faced by academia and quantum enterprises, we underline the relevance of interdisciplinary cooperation to move emerging quantum industry forward. The review consists of two main sections:Pathways towards the electron flying qubit:We address three routes of single-electron transport in GaAs-based devices focusing on surface acoustic waves, hot-electron emission from quantum dot pumps and Levitons. For each approach, we discuss latest experimental results and point out how numerical simulations facilitate engineering the electron flying qubit.Numerical modelling of quantum devices:We review the full stack of numerical simulations needed for fabrication of the flying qubits. Choosing appropriate models, examples of basic quantum mechanical simulations are explained in detail. We discuss applications of open-source (KWANT) and the commercial (nextnano) platforms for modelling the flying qubits. The discussion points out the large relevance of software tools to design quantum devices tailored for efficient operation.
Optimal Short-Circuit Resilient Formulas
Authors: Braverman Mark , Efremenko Klim , Gelles Ran , Yitayew Michael 
Published: August 2022

We consider fault-tolerant boolean formulas in which the output of a faulty gate is short-circuited to one of the gate’s inputs. A recent result by Kalai et al. [FOCS 2012] converts any boolean formula into a resilient formula of polynomial size that works correctly if less than 1/6 of the gates (on every input-to-output path) are faulty. We improve the result of Kalai et al., and show how to efficiently fortify any boolean formula against a fraction of 1/5 of short-circuit gates per path, with only a polynomial blowup in size. We additionally show that it is impossible to obtain formulas with higher resilience and sub-exponential growth in size.

Towards our results, we consider interactive coding schemes when noiseless feedback is present; these produce resilient boolean formulas via a Karchmer-Wigderson relation. We develop a coding scheme that resists corruptions in up to a fraction of 1/5 of the transmissions
in each direction of the interactive channel
. We further show that such a level of noise is maximal for coding schemes whose communication blowup is sub-exponential. Our coding scheme has taken a surprising inspiration from Blockchain technology.