bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergency department-based, nurse-initiated, serious illness conversation intervention for older adults: a protocol for a randomized controlled trial
Authors: Prachanukool Thidathit , Block Susan D. , Berry Donna , Lee Rachel S. , Rossmassler Sarah , Hasdianda Mohammad A. , Wang Wei , Sudore Rebecca , Schonberg Mara A. , Tulsky James A. , Ouchi Kei 
Published: September 2022

Abstract
Background: Visits to the emergency department (ED) are inflection points in patients' illness trajectories and are an underutilized setting to engage seriously ill patients in conversations about their goals of care. We developed an intervention (ED GOAL) that primes seriously ill patients to discuss their goals of care with their outpatient clinicians after leaving the ED. The aims of this study are: i) to test the impact of ED GOAL administered by trained nurses on self-reported, advance care planning (ACP) engagement after leaving the ED; and ii) to evaluate whether ED GOAL increases self-reported completion of serious illness conversation and other patient-centered outcomes.
Methods: This is a two-armed, parallel-design, single-blinded, randomized controlled trial of 120 seriously ill older adults in two academic and one community EDs in Boston, MA. Participants are English-speaking adults 50 years and older with a serious life-limiting illness with a recent ED visit. Patients with a valid MOLST (medical order for life-sustaining treatment) form or other documented goals of care within the last three months are excluded. We enroll the caregivers of patients with cognitive impairment. Patients are assigned to the intervention or control group using block randomization. A blinded research team member will perform outcome assessments. We will assess i) changes in ACP engagement (surveys, electronic medical record (EMR) documentation of new serious illness conversations, and self-reported completion of serious illness conversations) within six months; and ii) qualitative assessments of the effect of ED GOAL.
Discussion: In seriously ill older adults arriving in the ED, this randomized controlled trial will test the effects of ED GOAL on patients’ self-reported ACP engagement, EMR documentation of new serious illness conversations, and improving patient-centered outcomes.
Trial registration: Clinicaltrials.gov identifier: NCT05209880
Influence of the degree of obesity in obese euthyroid: An observational study of the correlation between body mass index (BMI) and thyroid stimulating hormone (TSH) in patients undergoing bariatric surgery.
Authors: Junior Adriano Francisco De Marchi , Pinheiro  , de Sibio Maria Teresa , de Oliveira  , Mazeto Glaucia Maria Ferreira da Silva , Nogueira Célia Regina 
Published: September 2022

Abstract
Objective: Although controversial, there may be a positive correlation between the body mass index (BMI) of individuals with obesity in euthyroidism and serum levels of thyroid stimulating hormone (TSH). This study aimed to evaluate the correlation between BMI and serum levels of TSH in individuals with morbid obesity undergoing bariatric surgery.
Patients and methods: The medical records of patients treated between the years 2012 and 2016 were used. A total of 96 patients with obesity, pre-surgery BMI ≥ 40 kg/m2, being followed up in the endocrinology unit, with mean age of 50 years, were evaluated pre and post operatively. In addition to the plasma TSH dosage by IRMA and plasma free T4 by RIE, age, BMI and biochemical parameters (glycaemia, total cholesterol and triglycerides) were analyzed.
Results: Patients with BMI > 40 kg/m2 prior to surgery showed higher serum TSH than subjects with a BMI <40 kg/m after surgery (2.48 ± 0.2 vs. 1.81 ± 0.25, p < 0.001). The decrease in BMI was accompanied by an improvement in the glycemic and lipid profiles, as well as free T4 and TSH levels are shown to accompany BMI.
Conclusion: Bariatric surgery was efficient in controlling obesity, since 100% of the patients had their degree of obesity decreased with concomitant metabolic improvement. We found that BMI and TSH are positively related, as post-surgical patients had both BMI and TSH decreased.
An Lncrna-disease Association Prediction Method Based on Nearest Neighbor Matrix Completion Model
Authors: Du Xiao-xin , Liu Yan , Wang Bo , Zhang Jian-fei 
Published: September 2022

Abstract
To address the problem that the traditional correlation metric defaults the 0 terms in the adjacency matrix of lncRNA-disease to irrelevant, ignoring the fact that it is only not validated now but maybe validated as relevant in the future, we propose a correlation calculation method that incorporates potential correlation properties, which is verified by comparative experiments to have better performance than the traditional method in the model; meanwhile, with the idea of nearest neighbor, we design the matrix completion model (DMWNN) to reassign values to the 0-terms in the adjacency matrix. The correlation is used instead of the traditional Euclidean distance to screen more valuable neighbors; combined with the linear decay strategy of distance weights, the interference of low correlation data is reduced, and thus the accuracy of reassignment is improved. The AUC value reached 0.9480 in the five-fold cross-validation experiment and 0.9603 in the leave-one-out cross-validation experiment, and the experimental results showed that the DMWNN model can effectively explore the potential association between lncRNA and disease and has strong predictive performance.
Turning parameters optimization for machining TC21 Ti- alloy Using Taguchi Technique
Authors: Sobh Arafa S. , Sayed Esraa M. , Barakat Azza F. , Elshaer Ramadan N. 
Published: September 2022

Abstract
The development of materials fabrication is an important trend in materials engineering. TC21) is one of these materials trend. This study aims to improve surface roughness and wear of tool insert using a turning process. To achieve this aim, experimental work will be conducted under three varying cutting parameters, each one of them with three levels. Cutting speeds (V) of 80, 100 and 120 m/min, feed rates (f) of 0.05, 0.10 and 0.15 mm/rev and cutting depth (a) of 0.2, 0.4 and 0.6 mm. The turning experiments optimization will be determined using the Taguchi technique by applying orthogonal array (OA) L9. Minitab (19) software is utilized to get the optimum turning parameters using analysis of signal to noise ratio (S/N). The results revealed that the cutting depth, and the cutting speed are the most significant parameters on surface roughness and wear of tool insert, respectively. Minimum surface roughness at V = 80 m/min, f = 0.10 mm/rev and a = 0.4 mm is 0.16 dB, and maximum surface roughness at V = 80 m/min, f = 0.15 mm/rev, and a = 0.6 mm is 0.72 dB. Minimum tool wear at V = 100 m/min, f = 0.15 mm/rev, and a = 0.2 is 187.770 µm, and the maximum tool wear at V = 80 m/min, f = 0.10 mm/rev, and a = 0.4 mm is 274.896 µm. Additionally, the validation model indicated that the deviation value of surface roughness is 6.564% (< 10%), and of tool wear is 8.76% (< 10%).
Planning and layout of tourism and leisure facilities based on POI big data and machine learning
Authors: Wu Shifeng , Wang Jiangyun , Li Jixiu , Jia Yinuo 
Published: September 2022

Abstract
This paper takes the Beijing's main urban as the research object, utilizing machine learning method to quantitatively simulate the location and layout of tourism and leisure facilities. POI data on the grid scale of 1km and the population data of the "the 6th Census" were used, combined with the existing distribution characteristics of tourism and leisure facilities in the Beijing's main urban. Finally, the model is used to simulate and predict each grid in the Beijing's main urban to see if it is suitable for new tourism and leisure facilities. This article simulates 949 suitable sites from the 1548 grids in the Beijing's main urban, and then further filters out 500 sites that need to be prioritized according to the population density of each main urban area to initially realize tourism at a refined scale. Quantitative site selection of leisure facilities. The research found that: ①Comparing the model simulation results with the existing tourism and leisure facilities, the accurate percentage is 95.1%, indicating the level of reliabity. ②The prediction results show that the newly added tourism and leisure facilities in the Beijing's main urban are mainly located in the densely populated areas of the Beijing's main urban. ③ The research attempts to use machine learning algorithms to plan the site selection of tourism and leisure facilities, which can optimize the overall layout and avoid the influence of subjectivity in planning on site selection. It also has certain reference value for the site selection method of other public facilities.
A framework for identification of the readiness and suitability of multicultural postgraduate research degree candidates
Authors: Cardona Magnolia , Motamedi Derakhshaneh 
Published: September 2022

Abstract
International students, particularly those from non-English speaking countries seeking admission to higher degree by research in Anglophone universities face multiple challenges in understanding the educational system rules, and socially adapting to the host country. Through a targeted literature search we identified barriers and facilitators to the multicultural students’ integration into a foreign education system which could hinder either their admission to postgraduate research courses or their performance during Master’s or doctoral enrolment. The four emerging themes were incorporated into checklists: English proficiency, Academic literacy, Communication and interpersonal skills, and Socio-demographic and cultural influences. These formed the basis for the development of the Supervisor’s Tool for Assessment of Readiness (STAR), an amalgamation of the checklists to provide an objective and comprehensive view of all aspects potential supervisors -and higher degree by research candidates- need to consider in the postgraduate admission process. We encourage readers to test and validate STAR in their academic environments and modify to suit their local needs.
Africa’s Manufacturing Puzzle: Evidence from Tanzanian and Ethiopian Firms
Authors: Rodrik Dani , Diao Xinshen , McMillan Margaret , Ellis Mia 
Published: September 2022

Abstract
Recent growth accelerations in Africa are characterized by declining shares of the labor force employed in agriculture, increasing labor productivity in agriculture, and declining labor productivity in modern sectors such as manufacturing. To shed light on this puzzle, we disaggregate firms in the manufacturing sector by average size using two newly created firm-level panels covering Tanzania (2008-2016) and Ethiopia (1996-2017). We identify a dichotomy between larger firms with superior productivity performance that do not expand employment and small firms that absorb employment but do not experience much productivity growth. Large, more productive firms use highly capital-intensive techniques, in line with global technology trends.
JEL Classification O14, O47
Experimental and Numerical Simulation Study on Forming and Thermal Distribution of a New Composite Annular Electrode Joint
Authors: Zhao Dewang , Chao Zhang , Ren Daxin , Zhao Kunmin 
Published: September 2022

Abstract
When welding high-strength steel and ultra-thin plates, traditional resistance spot welding has technical problems such as a narrow process window and difficulty in ensuring both welding strength and forming quality, making it one of the bottlenecks in the manufacture of high-end structural parts in the fields of vehicles, aviation and aerospace. The core reason is that the traditional spot welding thermal cycle mode is single, the energy is highly concentrated, and the controllability is poor. Therefore, there is an inconsistency between its energy distribution and nugget quality. In view of the above difficulties, a new idea of resistance spot welding of special-shaped electrodes based on energy distribution design is proposed. By inlaying insulating ceramics and other materials on the electrode end face, a "composite annular electrode" is prepared to realize the regulation of energy distribution in the welding process. In this paper, the thermo-electric-structural coupling FEM of a new composite electrode is established to reveal the detailed influence of the diameter of the ceramic core on the joint forming and thermal distribution. And the optimal ceramic core diameter is optimized for ultra-thin plates and high-strength steel plates commonly used in automobiles.
Developing intercultural competence in multilingual science classrooms: a narrative study
Authors: Ganesan Uma , Morales Amanda R. 
Published: September 2022

Abstract
Increased globalization of the world economy, growth in human migration, and rapid developments in science and technology have required people to develop intercultural communication skills. Teachers play a crucial role in developing intercultural competence among students in our globalized, multilingual classrooms. The need for fostering discourse and building intercultural competence among students is a common blind spot in teacher praxis. This can inhibit efforts to cultivate safe and supportive learning environments for all students and can ultimately threaten multilingual student success. As part of a larger study, this narrative inquiry explores the phenomenon of intercultural competence development through the lived experiences of a Midwestern secondary science teacher. Time-series data were collected from the participant (11 semi-structured, in-depth, online interviews over eight months). Field notes and artifacts served as secondary data. Informed by Michael Byram’s Multidimensional Model of Intercultural Competence, interviews were designed, conducted, transcribed, and member-checked. Then, transcripts, field notes, and artifacts were coded and analyzed using Jean Clandinin and Michael Connelly’s three-dimensional narrative inquiry framework to arrive at synthesized stories of experience around coalescing themes. The findings revealed the participant utilized several strategies aimed at developing intercultural communicative competence, particularly in support of multilingual students. This paper focuses on the four themes that relate most directly to intercultural communicative competence development. The findings and implications are discussed within the context of Byram’s model and conclusions are drawn to inform current and future work in this area.
Choroidal venous overload in Vogt‒Koyanagi‒Harada disease
Authors: Noh Hoon , Nam Seung Wan , Yoon Je Moon , Ham Don-Il 
Published: September 2022

Abstract
This study aimed to investigate the change of choroidal venous overload in Vogt‒Koyanagi‒Harada (VKH) disease. Clinical records of 52 patients with VKH disease (52 eyes) and 24 control subjects (24 eyes) who underwent multimodal imaging, including fluorescein angiography (FA) and indocyanine green angiography (ICGA), were retrospectively reviewed. Imaging data were assessed for signs associated with choroidal venous overload, e.g., choroidal perfusion delay, choroidal vascular hyperpermeability, dilated choroidal veins, and intervortex venous anastomosis (IVA). Dual FA and ICGA scoring for active posterior segment inflammation was performed. Clinical and imaging features associated with choroidal venous overload were compared between early- and late-stage VKH disease. Choroidal perfusion delay, choroidal vascular hyperpermeability, dilated choroidal veins, and IVA were more prevalent in eyes with VKH disease (69.2%, 67.3%, 61.5%, and 65.4%, respectively) than in control eyes (25.0%, 20.8%, 25.0%, and 37.5%, respectively) (p < 0.05). All eyes with IVA in the early-stage of VKH disease had got other 3 signs. All choroidal venous overload signs were more prevalent in patients with early-stage (20 eyes) than in those with late-stage VKH disease (32 eyes) (p < 0.05). The number of choroidal venous overload signs were inversely related to disease duration (p < 0.001) and proportionally related to the total ICGA score (p < 0.001). IVA was significantly associated with the total ICGA score in logistic regression (p = 0.014). Choroidal venous overload occurs early in VKH disease. Angiographic signs of choroidal venous overload may be useful markers to assess the status of VKH disease.
The association of red blood cell markers with NAFLD and advanced liver fibrosis
Authors: Gu Ting , Yang Naibin , Chen Yuanwen 
Published: September 2022

AbstractBackground:Nonalcoholic fatty liver disease (NAFLD) is an increasing disease related with metabolic syndrome (MetS). The associations between red blood cell (RBC) markers and MetS have been reported. However, whether RBC markers, including RBC count, mean corpuscular hemoglobin concentration(MCHC), and red blood cell distribution width (RDW)are associated with the risk of NAFLD and advanced liver fibrosis are still unclear.Methods:We conducted a nationally representative cross-sectional study based on National Health and Nutrition Examination Survey (NHANES) 2017-2018. NAFLD was diagnosed when controlled attenuation parameter (CAP) values ≥263 dB/m after exclusion of hepatitis B or C virus infection and significant alcohol intake. Advanced liver fibrosis was confirmed when liver stiffness measurement (LSM)≥8.6kPa. Weighted multivariable logistic regression models were performed to investigate the associations of RBC markers with NAFLD and advanced liver fibrosis.Results:3563 participants were finally included. Of all the participants, 1818 (51%) were diagnosed as NAFLD and 288(8%) had advanced liver fibrosis. After fully adjusting potential confounders, RBC count was positively associated with NAFLD (OR=1.5, 95% CI=1.2-1.8, P<0.001) or CAP (β=12.1, 95% CI= 8.1-16.2, p <0.001) while MCHC was also positively associated with NAFLD (OR=1.2, 95% CI=1.1- 1.3, P=0.003) or CAP (β=2.7, 95% CI= 0.6-4.8, p=0.013). After fully adjusting potential confounders, RDW was positively associated with advanced liver fibrosis (OR=1.3, 95% CI=1.1-1.4, P<0.001) and LSM (β=0.2, 95% CI= 0.1-0.3, p =0.005).However, there was no significant difference in RBC count or MCHC with advanced liver fibrosis or LSM. Moreover, no significant difference was detected between RDW and NAFLD or CAP.Conclusion: We revealed that RBC count and MCHC were positively associated with NAFLD while RDW was positively associated with advanced liver fibrosis in Americans.
The haemostatic effect of deep-frozen platelets versus room temperature stored platelets in the treatment of surgical bleeding. MAFOD: study protocol for a randomized controlled non-inferiority trial
Authors: Rijnhout Tim , Noorman Femke , Horst Robert A. Van der , Tan Edward C.T.H. , Viersen Victor V.A. , Waes Oscar J.F. Van , de Watering Leo M.G. Van , Burg Boudewijn B.L.S. Borger van der , Zwaginga Jaap Jan , Verhofstad Michael H.J. , Hoencamp Rigo 
Published: September 2022

AbstractBackground : The Netherlands Armed Forces have been successfully using deep frozen (-80°C) thrombocyte concentrate (DTC) for the treatment of (massive) bleeding trauma patients in austere environments since 2001. However, high-quality evidence for effectiveness and safety of DTCs is currently lacking. Therefore, the MAssive transfusion of Frozen bloOD (MAFOD) trial is designed to compare the haemostatic effect of DTCs versus room temperature stored platelets (RSP) in the treatment of surgical bleeding. Methods : The MAFOD trial is a single-blinded, randomized controlled non-inferiority trial and will be conducted in three level 1 trauma centres in the Netherlands. Patients of 12 years or older, alive at hospital presentation, requiring a massive transfusion including platelets, and with signed (deferred) consent will be included. The primary outcome is the percentage of patients that have achieved haemostasis within six hours and show signs of life. Haemostasis is defined as the time in minutes from arrival to the time of the last blood component transfusion (plasma/platelets or red blood cells), followed by a two-hour transfusion free period. This is the first randomized controlled study investigating DTCs in trauma- and vascular surgical bleeding. Discussion: The hypothesis is that the percentage of patients that will achieve haemostasis in the DTC group is at least equal to the RSP group (85%). With a power of 80%, a significance level of 5% and a non-inferiority limit of 15%, a total of 71 patients in each arm are required. Thus, resulting in a total of 158 patients, including a 10% refusal rate. The data collected during the study could help improve the use of platelets during resuscitation management. If proven non-inferior in civilian setting, frozen platelets may be used in the future to optimize logistics and improve platelet availability in rural or remote areas for the treatment of (massive) bleeding trauma patients in civilian settings. Trial registration: ClinicalTrials.gov NCT05502809. Registered on 16 August 2022. Keywords : Transfusion; cryopreservation; trauma; bleeding; haemorrhage; platelets; resuscitation; injury; blood; coagulopathy
Multiple endocrine neoplasia type 2B with hyperparathyroidism: A case report and literature review
Authors: Ye Yunjie , Deng Zicong , Tu Hengjia , Gao Yuan , Liu Yongkang , Chen Xiaoyan , Deng Shunyou , Lu Ke , Huang Caimao , Tan Yuyu 
Published: September 2022

Abstract
MEN2B is characterized by medullary thyroid carcinoma (MTC), pheochromocytoma (PHEO) and without hyperparathyroidism, over 95% of which patients have mutations in codon M918T (at exon 16). Early diagnosis of MEN2B has important implications for the treatment and prognosis of the disease, as thyroidectomy has the potential to cure patients. In this case, the patient was a 31-year-old man presented with low back pain as the initial and primary symptom. In addition to MTC and PHEO, the examination showed that he also had hyperparathyroidism, which led to the misjudgment of MEN typing at first. We finally diagnosed this patient as MEN2B based on the results of genetic testing. After the operation and treatment, the patient recovered well. Early diagnosis is the key to the MEN2B treatment. Whether MEN2A and MEN2B can be distinguished by the presence of parathyroidism still needs more researches to verify. RET gene detection plays an important role in the diagnosis and prognosis of MEN2B and surgery is the first choice for the treatment of MEN2B.