bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH MEDIA ANIMASI WAYANG SUKURAGA PADA MATERI CUACA UNTUK MENINGKATKAN LITERASI SAINS SISWA KELAS RENDAH
Authors: Putri Ratu Fakhira , Sutisnawati Astri , Nurmeta Irna Khaleda , Martiningsih Irmawati , Lisdianingsih Lisdianingsih 
Published: August 2022

Penelitian ini bertujuan untuk mengetahui apakah literasi sains siswa yang menggunakan media animasi wayang sukuraga pada pembelajaran IPA materi cuaca lebih baik dari siswa yang menggunakan model pembelajaran langsung dan untuk mengetahui apakah terjadi peningkatan literasi sains siswa. Jenis penelitian ini adalah penelitian kuantitatif dengan menggunakan metode eksperimen. Desain eksperimen yang digunakan design dengan populasi penelitian 2 kelas yang diambil dari kelas rendah A dan B di SDN Hegarmanah Sukabumi. Sampel penelitian menggunakan teknik purposive sampling. Instrumen yang digunakan dalam penelitian ini adalah instrumen test. Berdasarkan uji prasyarat data diketahui bahwa data hasil penelitian berdistribusi normal maka, dilakukan uji lanjutan yaitu uji t dua sampel independen. Ada perbedaan yang signifikan terhadap literasi sains siswa siswa, ini dibuktikan dengan uji t dua sampel independen maka penelitian ini menolak H0 dan menerima H1. Dengan demikian, dapat disimpulkan bahwa literasi sains siwa yang menggunakan media animasi wayang sukuraga lebih baik dari siswa yang menggunakan model pembelajaran langsung. Terjadi peningkatan literasi sains siswa yang mengikuti pembelajaran dengan menggunakan media animasi wayang sukuraga pada materi cuaca.
PENERAPAN PEMBELAJARAN KOLASE SEBAGAI UPAYA EDUKASI FAUNA DI SEKOLAH DASAR
Authors: Saida Naili , Yunitasari Anisa 
Published: August 2022

Abstrak: Penelitian ini bertujun untuk mengetahui pemahaman peserta didik tentang fauna Indonesia melalui pembelajaran kolase. Penelitian ini menggunakan pendekatan penelitian kuantitatif dengan desain pre eksperimen one group pre test dan post test. Sampel dalam penelitian ini adalah peserta didik kelas 3 SD Negeri Jambesari 03 yang terdiri dari 10 anak. Teknik pengumpulan data yang digunakan adalah observasi, tes tulis dan dokumentasi. Analisis data dalam penelitian ini menggunakan uji wilcoxon. Hasil penelitian diperoleh data pada taraf signifikansi α=0,05 diketahui Ttabel= 8 dan Thitung = 0, dengan demikian diketahui bahwa nilai Thitung < Ttabel , sehingga menunjukkan bahwa H0 ditolak dan Ha diterima. Dengan demikian pembelajaran kolase mampu menambah pemahaman peserta didik tentang fauna Indonesia. Pembelajaran kolase yang dilakukan mampu menumbuhkan rasa semangat anak untuk mengikuti pembelajaran yang dilakukan. Pada pembelajaran kolase yang dilakukan anak mampu mengenal 12 macam fauna di Indonesia yang dilindungi. Kata Kunci: Edukasi Fauna; Pembelajaran kolase; Peserta didik
La articulación etnográfica. Descubrimiento y trabajo de campo de la investigación de Esther Hermitte
Authors: Godoy Maria Celeste 
Published: August 2022

Autor: Rosana GuberTítulo: La articulación etnográfica. Descubrimiento y trabajo de campo de la investigación de Esther HermitteEditorial: Editorial Biblos2013, Buenos Aires.
Mechanisms of heightened pain-related disability in Canadian Armed Forces members and Veterans with comorbid chronic pain and PTSD
Authors: Maunder Larah , Marriott Emily , Katz Joel , Salomons Tim V. 
Published: August 2022

LAY SUMMARY Canadian Armed Forces (CAF) members and Veterans with chronic pain and posttraumatic stress disorder (PTSD) symptoms were surveyed. Participants with a high number of PTSD symptoms had a higher vulnerability to becoming psychologically traumatized by their chronic pain than participants with a low number of PTSD symptoms. In turn, participants with this high vulnerability reported experiencing more disability from their chronic pain than participants with a low vulnerability. In addition, participants with a high number of PTSD symptoms tended to have many catastrophic thoughts about their pain. In turn, these participants reported experiencing more disability from their chronic pain than participants with few catastrophic thoughts about their pain. PTSD may lead servicemembers and Veterans to experience high disability from their chronic pain by increasing how traumatized they feel by their pain and by increasing the number of catastrophic thoughts they have about their pain. Targeting pain-related psychological trauma symptoms and catastrophic thoughts when treating servicemembers and Veterans with chronic pain and PTSD may be effective at reducing disability from chronic pain.
Molecular characteristics of incidental lower-grade glioma for treatment decision-making
Authors: Park Jeongman , Sim Jeongmin , Ahn Juwon , Kim Yu Jin , Hwang Sojung , Cho Kyunggi , Chang Da-Young , Jung Jin-Hwa , Moon Ju Hyung , Sung KyoungSu , Lim Jaejoon 
Published: August 2022

OBJECTIVE
Several limitations are associated with the early diagnosis and treatment of incidental lower-grade glioma (iLGG), and due to its unknown molecular features, its management is categorized as either the “wait-and-see” strategy or immediate treatment. Therefore, in this study the authors explored iLGG’s clinical and molecular landscape to improve its management.

METHODS
The authors retrospectively assessed the differences between the molecular and clinical characteristics of iLGG and symptomatic lower-grade glioma (sLGG) samples filtered based on symptom data corresponding to The Cancer Genome Atlas cohort with mutations. Thereafter, genomic and transcriptomic analysis was performed.

RESULTS
There was no significant difference between iLGG and sLGG with respect to mutation status; however, there was an increase in the interaction between major mutations in sLGG, depending on the histological subtype and the IDH1 mutation status. Furthermore, the IDH1 mutation characteristics corresponding to wild-type glioma were much more obvious in sLGG than in iLGG. Additionally, in sLGG, genes associated with malignancy, including cell proliferation–related, cell migration–related, epithelial-to-mesenchymal transition–related, and negative regulation of cell death–related genes, were significantly upregulated, and groups showing higher expression levels of these genes were associated with worse prognosis. Also, 8 of the 75 identified upregulated genes showed positive correlation with resistance to the drugs that are normally used for glioma treatment, including procarbazine, carmustine, vincristine, and temozolomide.

CONCLUSIONS
The new insights regarding the different molecular features of iLGG and sLGG indicated that the immediate management of iLGG could result in better prognosis than the wait-and-see strategy.
Efficiency of different potassium and sulfur fertilizers on peanut (Arachis hypogaea) production in tropical sandy soil
Authors: HOA HOANG THI THAI , THUC DO DINH , NHAN DO THANH 
Published: August 2022

In the sandy soil of Vietnam's South-Central Coast, peanuts are a significant crop. The application of K and S needs to crops has recently attracted a lot of interest, especially for peanut. However, a comparison on the effects of different types of K and S fertilizers viz., ammonium sulphate (AS), superphosphate (SP), NPKS, potassium sulphate (SOP), and potassium chloride (MOP) is to be evaluated on the yield, quality, and K and S content in peanut seed. This study was conducted during winter spring and summer seasons 2019 - 2020 at Binh Dinh province (SCCVN). Equal rate of 75 kg K/ha and 30 kg S/ha was applied as SOP, NPKS and a mixture of AS, SP, MOP and these were compared against a control which applied nitrogen (N) and phosphorus (P) fertilizers. SOP application resulted in the highest yield (2.93 - 4.92 t/ha), protein (24 %), lipid (53 %) and seed K (0.19-0.53 %) and seed S (0.57-0.69 %). The study concluded that application of 75 kg K/ha and 30 kg S/ha in SOP fertilizer based on @ 8 tons of cattle manure + 40 kg N + 40 kg P + 500 kg lime/ha is suitable for peanut crop in SCCVN.
Pengembangan Media Pop-up Book Berbasis Kearifan Lokal Sebagai Penguatan Pendidikan Karakter Gotong Royong
Authors: Puspita Ari Metalin Ika , Setyaningtyas Diah 
Published: August 2022

Penelitian pengembangan media dilatar belakangi oleh rendahnya sikap gotong royong siswa di SDN 1 Kelutan, SDN 2 Karangan dan SDN 2 Jati. Selain itu kurangnya dalam pemanfaatan media pembelajaran membuat siswa kurang memperhatikan pembelajaran. Tujuan penelitian yang dilakukan adalah memberikan penguatan pendidikan gotong royong pada siswa dengan bantuan media pop-up book. Metode yang digunakan yaitu (RnD) dengan jenis model ADDIE. Tahapan ADDIE sendiri terdiri dari tahapan Analysis (Analisis), Design (Desain), Development (Pengembangan), Implementation (Penerapan), and Evaluation (Evaluasi). Teknik sampling yang menggunakan sampling jenuh dengan sampel siswa kelas II SDN 1 Kelutan, SDN 2 Jati dan SDN 2 Karangan. Instrumen yang digunakan yaitu pedoman wawancara, angket validasi ahli, angket praktisi,angket prototipe, angket pendidikan karakter, angket respon oleh siswa dan guru. Analisis menggunakan Paired Sample T-Test berbantuan Software SPSS 25.0. Berdasarkan validasi ahli, media pop-up book memenuhi kategori sangat valid, kemudian penilaian praktisi dan prototipe menunjukkan kategori praktis, dan hasil angket respon siswa masuk kategori menarik. Uji beda yang dilakukan menunjukkan hasil signifikansi 0,00 (< 0,05). Sehingga disimpulkan pop-up book efektif digunakan sebagai penguat Pendidikan karakter gotong royong di dalam proses pembelajaran siswa SDN 1 Kelutan, SDN 2 Jati dan SDN 2 Karangan.
eHealth platforms for promoting active living: a scoping review protocol
Authors: Apóstolo João , Bernardo Joana , Loureiro Ricardo , Santana Elaine , Duque Filipa Margarida , Dantas Carina , Ventura Filipa , Silva Rosa 
Published: August 2022

Introduction: In increasingly aging societies, the life course towards aging should be a positive experience supported by interventions for promoting healthy lifestyles, namely through social interaction. Technological advancements, such as eHealth platforms, are becoming increasingly available and may facilitate a more autonomous life and promote active and healthy living. Objectives: To map eHealth platforms designed and used to promote autonomous life and active aging. Methods: This scoping review will follow the JBI methodology for scoping reviews. Two independent reviewers will appraise the articles and extract and synthesize data. This review will include studies published in Spanish, English, and Portuguese, without any time restrictions. The following databases will be searched: MEDLINE (via PubMed), CINAHL Complete (via EBSCOhost), Scopus, Cochrane Database of Systematic Reviews (via EBSCOhost), SciELO, DART-Europe, CAPES, and MedNar. Results: This scoping review is expected to include studies addressing eHealth platforms that promote autonomous life and active aging. Conclusion: This scoping review will analyze and synthesize the available scientific evidence on using eHealth platforms to promote autonomous life and active aging. It may also be the basis for a systematic review and/or help identify gaps where it may be important to invest in the future.
Brain ethanolamine phospholipids, neuropathology and cognition: A comparative post-mortem analysis of structurally specific plasmalogen and phosphatidyl species
Authors: Goodenowe Dayan B. , Senanayake Vijitha 
Published: August 2022

Reduced cognition in the elderly is associated with low levels of plasmalogens and high levels of lipid rafts, amyloid plaques, and neurofibrillary tangles in the temporal cortex. A systematic integrative analysis of key indices of these pathologies to determine their collective and independent contributions to cognition was performed. Levels of four phosphatidylethanolamines (PE) and four ethanolamine plasmalogens (PL) of identical sn-1 carbon length and desaturation (stearic, 18:0) and identical sn-2 fatty acid compositions of varying side chain lengths and degrees of unsaturation (oleic, 18:1; linoleic, 18:2; arachidonic, 20:4; docosahexaenoic, 22:6), flotillin-1 expression and amyloid plaque and neurofibrillary tangle densities were measured in inferior temporal cortex tissue from 100 elderly subjects (Rush University Memory and Aging Project, 88.5 ± 5.8 years old). Subjects were evenly distributed with respect to gender (52/48, F/M) and cognitive status (38/24/38, no cognitive impairment/mild cognitive impairment/Alzheimer’s dementia) proximate to death. Multivariate logistic regression analyses were used to determine the relative and collective associations of the neuropathological indices with cognition. Higher levels of tangles, amyloid, or flotillin and lower levels of PL 18:0/22:6 were significantly associated with lower cognition in the base model (adjusted for age, sex, education). Multivariate analysis revealed that only PL 18:0/22:6 (β = 0.506; p &lt; 0.00001), tangles (−0.307; p &lt; 0.01), and flotillin (−0.2027; p &lt; 0.05) were independently associated with reduced cognition. PL 18:0/22:6 and PE 18:0/22:6 levels were independently associated with cognition in the presence of tangles, amyloid, and flotillin, but only PL 18:0/22:6 retained its association with cognition when both PL and PE 18:0/22:6 were included in the model indicating that PE 18:0/22:6 levels were associated with PL 18:0/22:6, not cognition. Only high brain levels of PL 18:0/22:6 (&gt;mean+1SD) was predictive of normal cognition (coef = 1.67, p &lt; 0.05) and non-demented state (coef = −2.73, p &lt; 0.001), whereas low levels of PL 18:0/22:6 and high levels of tangles or flotillin were predictive of dementia. The association of high brain polyunsaturated (PUFA)-PL levels with better cognition was independent of amyloid plaque, neurofibrillary tangle, PE, and flotillin-1 expression. Maintenance or augmentation of brain docosahexaenoic (DHA)-PL levels warrants further investigation as a target for preventing cognitive decline or improving cognition in the elderly, respectively.
Cucurbit [8] uril-based supramolecular fluorescent biomaterials for cytotoxicity and imaging studies of kidney cells
Authors: Xiao Han , Yang Xia , Yang Li , Yang Dan , Luo Yang , Yang Hai-Ping , Tao Zhu , Xiao Xin , Li Qiu 
Published: August 2022

An accurate diagnosis of acute kidney injury (AKI) at the early stage is critical to not only allow preventative treatments in time but also forecast probable medication toxicity for preventing AKI from starting and progressing to severe kidney damage and death. Therefore, supramolecular fluorescent biomaterials based on Q [8] and PEG-APTS have been prepared herein. This study has found that the unique properties of outer surface methine and the positive density of Q [8] can form a stable assembly with PEG-APTS, and has provided the possibility for the faster crossing of the glomerular filtration barrier to enter into the resident cells of the kidney. In addition to the excellent fluorescence properties, the as-synthesized biomaterial Q [8]@PEG-APTS has possessed significantly low biological toxicity. Most importantly, the accumulation of Q [8]@PEG-APTS in large amounts in cytoplasm and nucleus of HK2 and HMCs cells, respectively, within 24 h enabled distinguishing kidney cells when diagnosing and providing some foundation for early AKI.
A comparison of the composition and functions of the oral and gut microbiotas in Alzheimer’s patients
Authors: Chen Lili , Xu Xinhua , Wu Xiaoqi , Cao Huizhen , Li Xiuli , Hou Zhaoyi , Wang Bixia , Liu Jinxiu , Ji Xinli , Zhang Ping , Li Hong 
Published: August 2022

ObjectiveAlterations in the oral or gut microbiotas have been reported in patients with subjective and mild cognitive impairment or AD dementia. However, whether these microbiotas change with the severity of the AD spectrum (mild, moderate, and severe AD) remains unknown. Thus, we compared alterations in the composition and gene functions of the oral and gut microbiota between different phases of AD.MethodsWe recruited 172 individuals and classified these into three groups: healthy controls (n = 40), a mild AD group (n = 43) and a moderate AD group (n = 89). Subgingival plaques and fecal samples were collected from all individuals. Then, we conducted 16S ribosomal RNA. sequencing to analyze the microbiotas.ResultsIn order of the severity of cognition impairment (from normal to mild and to moderate AD), the oral abundances of the phyla Firmicutes and Fusobacteria showed a gradual upwards trend, while the abundance of the Proteobacteria phylum gradually decreased. In contrast, the abundance of the Firmicutes and Bacteroidetes phyla in the gut decreased progressively, while that of the Proteobacteria, Verrucomicrobia and Actinobacteria phyla increased gradually. Key differences were identified in the microbiomes when compared between the mild AD and moderate AD groups when applying the linear discriminant analysis effect size (LEfSe) algorithm. LEfSe analysis revealed alterations that were similar to those described above; furthermore, different bacterial taxa were associated with MMSE scores and age. KEGG analysis showed that the functional pathways associated with the oral microbiota were mainly involved in membrane transport and carbohydrate metabolism, while the gene functions of the fecal microbiota related to metabolism of amino acids, energy, cofactors and vitamins; identified significant differences among the three groups. Venn diagram analysis revealed that the number of genera that were present in both the oral and gut microbiota increased progressively from NC to mild AD and then to moderate AD.ConclusionsThis study is the first to report a comparative analysis of the oral and fecal microbiota of patients with mild and moderate AD. The compositions and functions of the oral and gut microbiotas differed when compared between different stages of AD.
Intra-cardiac pressure drop and flow distribution of bicuspid aortic valve disease in preserved ejection fraction
Authors: Aliabadi Shirin , Sojoudi Alireza , Bandali Murad F. , Bristow Michael S. , Lydell Carmen , Fedak Paul W. M. , White James A. , Garcia Julio 
Published: August 2022

BackgroundBicuspid aortic valve (BAV) is more than a congenital defect since it is accompanied by several secondary complications that intensify induced impairments. Hence, BAV patients need lifelong evaluations to prevent severe clinical sequelae. We applied 4D-flow magnetic resonance imaging (MRI) for in detail visualization and quantification of in vivo blood flow to verify the reliability of the left ventricular (LV) flow components and pressure drops in the silent BAV subjects with mild regurgitation and preserved ejection fraction (pEF).Materials and methodsA total of 51 BAV patients with mild regurgitation and 24 healthy controls were recruited to undergo routine cardiac MRI followed by 4D-flow MRI using 3T MRI scanners. A dedicated 4D-flow module was utilized to pre-process and then analyze the LV flow components (direct flow, retained inflow, delayed ejection, and residual volume) and left-sided [left atrium (LA) and LV] local pressure drop. To elucidate significant diastolic dysfunction in our population, transmitral early and late diastolic 4D flow peak velocity (E-wave and A-wave, respectively), as well as E/A ratio variable, were acquired.ResultsThe significant means differences of each LV flow component (global measurement) were not observed between the two groups (p &gt; 0.05). In terms of pressure analysis (local measurement), maximum and mean as well as pressure at E-wave and A-wave timepoints at the mitral valve (MV) plane were significantly different between BAV and control groups (p: 0.005, p: 0.02, and p: 0.04 and p: &lt;0.001; respectively). Furthermore, maximum pressure and pressure difference at the A-wave timepoint at left ventricle mid and left ventricle apex planes were significant. Although we could not find any correlation between LV diastolic function and flow components, Low but statistically significant correlations were observed with local pressure at LA mid, MV and LV apex planes at E-wave timepoint (R: −0.324, p: 0.005, R: −0.327, p: 0.004, and R: −0.306, p: 0.008, respectively).ConclusionIn BAV patients with pEF, flow components analysis is not sensitive to differentiate BAV patients with mild regurgitation and healthy control because flow components and EF are global parameters. Inversely, pressure (local measurement) can be a more reliable biomarker to reveal the early stage of diastolic dysfunction.
Left ventricular dyssynchrony as marker of early dysfunction in premature ventricular contraction-induced cardiomyopathy
Authors: Kowlgi Gurukripa N. , Tan Alex Y. , Kaszala Karoly , Kontos Michael C. , Lozano Pedro , Ellenbogen Kenneth A. , Huizar Jose F. 
Published: August 2022

BackgroundStrain imaging has been suggested as a tool to detect early left ventricular (LV) dysfunction due to frequent premature ventricular contractions (PVCs) in patients with preserved LV ejection fraction (EF). However, the progression of intraventricular dyssynchrony (IVD), radial, and circumferential strain (RS, CS) in PVC-cardiomyopathy (CM) are unknown. The aim of this study was to elucidate the progression patterns of CS, IVD, and electro-mechanical latency (EML) in PVC-CM.Methods and resultsPacemakers were implanted in 20 canines to reproduce ventricular bigeminy at 200ms (PVCs n = 11) for 12 weeks and compared to a sham group (n = 9). We obtained echocardiograms at baseline, 4-, 8- and 12-weeks. RS and CS were obtained at the LV mid-cavitary level. IVD was defined as the time between the earliest and latest peak RS. EML was defined as the time between the onset of QRS and the earliest peak RS. LVEF (62 ± 5 to 42 ± 7%, p &lt; 0.01), CS (–18 ± 3 to –12 ± 3, p &lt; 0.01), and EML (219 ± 37 to 283 ± 46ms, p = 0.02) changed significantly in the PVC group. Peak CS (–18 ± 3 to –14 ± 4, p = 0.02) and IVD (49 ± 31 to 122 ± 103, p = 0.05) had a significant change at 4-weeks despite preserved LVEF (51 ± 5%). IVD normalized while EML increased at weeks 8 and 12.ConclusionOur findings consolidate the existing theory that changes in strain precede changes in LVEF in PVC-CM. While IVD becomes abnormal early in the development of PVC-CM, it pseudo-normalizes at advanced stages due to further increases in EML suggestive of cardiac contractility remodeling. These findings are consistent with recent published data where abnormal LV mechanics could be part of a substrate that can predispose to worse outcome in PVC-Cardiomyopathy.