bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation analysis of m6A-modified regulators with immune microenvironment infiltrating cells in lung adenocarcinoma
Authors: Ye Wei , Huang Tianpeng 
Published: February 2022

Object
Recent studies have demonstrated the epigenetic regulation of immune responses. However, the potential role of N6-methyladenosine methylation (m6A) in the tumor microenvironment (TME) remains unknown.

Method
In this study, the m6A modification patterns of LUAD samples were comprehensively evaluated by combining TCGA and GEO data, while these modification patterns were systematically linked to the characteristics of immune infiltrating cells in TME. The m6A score was constructed using the principal component analysis algorithm to quantify the m6A modification mode of a single tumor.

Result
There were three distinct patterns of m6A modification identified. The characteristics of TME cell infiltration in these three patterns were highly consistent with these three immune phenotypes of the tumors, including immune rejection, immune-inflammatory, and immune inert phenotypes. Low m6A scores were characterized by immune activation and poor survival rate. Besides, m6A scores were associated with tumor mutational load (TMB) and were able to increase the ability of TMB to predict immunotherapy. Two immunotherapy cohorts confirmed that the patients with lower m6A scores demonstrated significant therapeutic advantages and clinical benefits. m6A modifications play an important role in the development of TME diversity. Assessing the m6A modification pattern of individual tumors can deepen the understanding as to the characteristics of TME infiltration and guide more effective immunotherapy strategies.
Impacto de la Pandemia Por SARS-CoV-2 en la Salud Ocular Infantil
Authors: Castaño Robayo Giovanni 
Published: February 2022

Antecedentes: La infección por el virus SARS-CoV-2 ha causado una pandemia potencialmente mortal. La incidencia de la enfermedad obliga a considerar el impacto sobre la salud ocular infantil. Objetivo: Revisión de la literatura sobre el impacto de la pandemia causada por SARS-CoV-2 sobre la salud ocular infantil. Conclusiones: La afección ocular directa por el virus SARS-CoV-2 suele ser leve y superficial, pero las circunstancias propias de la necesidad de protección y aislamiento han generado múltiples problemas oculares en la infancia. El virus SARS-CoV-2, la cuarentena y demás medidas de protección necesarias para prevenir la infección, así como la presencia de partículas virales en la película lagrimal, tienen implicaciones en la salud ocular infantil que deben ser comprendidas por el personal de salud y la comunidad.
Isolated Gastritis Secondary to Immune Checkpoint Inhibitors Complicated by Superimposed Cytomegalovirus Infection
Authors: Nguyen Anita H. , Sagvand Babak Torabi , Hwang Daniel G. , Legesse Teklu , Cross Raymond K. 
Published: February 2022

ABSTRACT
Immune checkpoint inhibitors such as nivolumab increase the T-cell destruction of malignancies but can also trigger a broad variety of immune-related adverse events (irAEs). Colitis as an irAE is well-documented, but upper gastrointestinal tract involvement is primarily unrecognized. We present a patient who developed gastritis as an irAE after multiple cycles of nivolumab and initially responded well to steroid therapy but then developed superimposed cytomegalovirus infection. The similarity between both presentations highlights the importance of having a broad differential diagnosis in patients with gastrointestinal complaints treated with immune checkpoint inhibitors and the need for further studies to better characterize gastritis as an irAE.
The Investigation to the Learning Behaviour of Body Painting
Authors: WU LI-AN 
Published: February 2022

Amid the emergence of body painting as a new art form in the modern fashion industry, a growing number of vocational-technical schools in Taiwan have included this form of art into their programs. This study aims to use the Theory of Planned Behavior (TPB) in order to explore the learning behavior of body painting respondents in terms of their subjective norm, descriptive norm, attitude, personal norm, perceived behavioral control and intention.
In the research process, a questionnaire survey was conducted among body painting respondents in an independent sampling approach with the collection of 260 valid samples. The data are analyzed by using the statistical software package SPSS. The results indicate that all variables of the subjects-subjective norm, descriptive norm, attitude, personal norm, and perceived behavioral control, have a significant positive influence on their intention. Meanwhile, attitude has a partial mediation effect on the relationship between subjective norm and descriptive norm to intention. Personal norm has a partial mediation effect on the relationship between subjective norm and descriptive norm to intention. Perceived behavioral control has a complete mediation effect on the relationship between subjective norm and descriptive norm to intention.
FORCED TRANSVERSE VIBRATIONS OF FRACTIONAL VISCOELASTIC EULER-BERNOULLI BEAM USING THE MODAL ANALYSIS METHOD
Authors: Khang Nguyen Van , Phuong Nguyen Minh , Chung Pham Thanh 
Published: February 2022

In the paper, the forced transverse vibration of fractional viscoelastic Euler-Bernoulli is studied. Based on the fractional relationship of stress and strain, the partial differential equation describing transverse vibration of Euler-Bernoulli viscoelastic beam is considered. The Riemann-Liouville fractional derivative of the order and is used. Using the Ritz-Galerkin method, the fractional partial derivative equation describing the vibration of the beam is transformed into a system of differential equations containing fractional derivatives. The dynamic response of a simply supported fractional viscoelastic beam to a harmonic concentrated force is calculated in detail. The forced vibration solution of the beam is determined using the harmonic balancing method. The solution to the vibration equations is determined analytically, while dynamic responses are calculated numerically. The effects of fractional–order parameters on the vibration amplitude-time curves are investigated. From the calculation results, we can see that the lower the parameter is, the larger the vibration amplitude. This is consistent with our logic thinking. A comparison between the approximately analytical solution and the numerical one shows a good agreement, and the correctness of the obtained results is therefore verified.
Characterization of Common β-Thalassemia Major Mutations in Southwest Iran with Respect to Biochemical Parameters, Oxidative Status and Complications
Authors: Yaghooti H , Sadat Mirlohi M , Shirali S , AminAsnafi A 
Published: February 2022

Background & Objective: Beta-thalassemia are among the most common autosomal recessive genetic disorders in Iran, especially in Khuzestan province. Beta-thalassemia exhibits significant phenotype heterogeneity and there are currently more than 200 known mutations in this region. Oxidative stress exacerbates multiple disorders, including thalassemia, an inherited hemolytic anemia caused by globin gene mutations. We aim to characterize significant mutations of widespread β-thalassemia in south-western Iran with respect to biochemical parameters, oxidative status and complications of diseases.
Material & method: Forty-five patients, aged between 15-35 years with β-thalassemia major were selected. The patients were receiving regular blood transfusion and chelation therapy and have been previously characterized to bear beta globin gene mutations. The subjects’ medical histories were documented by review of previous medical records. We also determined biochemical parameters including glycemic and iron indices, hepatic and renal function tests, oxidative stress markers and levels of advanced glycation end product species (Carboxy methyl lysine and Pentosidin).
Results: The most common mutation was found to be CD36/37(28.9%) followed by IVSII-1, and IVSI-110. Values of iron indices were significantly different in various mutation groups. Carboxy methyl lysine and pentosidine were found to be higher in the β-thalassemia patients with IVSII-1 and IVSI-110, respectively. Also sLOX-1 was found to be significantly higher in IVSI-110 group. Complications of the disease were differently presented in mutation groups and hemochromatosis, hepatomegaly, and diabetes were among the most common problems.
Conclusion: About 72 % of β-thalassemia major cases in southwest Iran result form 3 common mutations with different clinical and laboratory presentations. Molecular genetic testing can be helpful to evaluate the patients’ situation.
Comparing The Effects of Selenium Nanoparticles and Selenium Nanocomposites on Food Intake and Anxiety-like Behaviors
Authors: Hajinezhad MR , Samzadeh Kermani AR 
Published: February 2022

Background & Objective: Selenium nanoparticles (Se -NPs) and selenium nanocomposites (Se -NCs) have different biological effects. Therefore, the present study aimed to compare the effects of selenium nanoparticles and selenium nanocomposites (Se –NCs) on anxiety, food intake, and brain histology of rats.
Materials & Methods: Thirty-two male adult Wistar rats were randomly and equally divided into four groups. The control group received saline, the Selenium powder group received 1 mg/kg /day selenium powder orally for 21 days, and the selenium nanoparticle group received three weeks of oral gavage of Se –NPs. The selenium nanocomposites group received three weeks of oral gavage of nanocomposites. Finally, cumulative food consumption and anxiety-like behaviors were assessed, and, after that, rats were bled and sacrificed for further biochemical and histopathological investigations.
Results: Oral administration of Se powder at a dose of 1 mg/kg /day for 21 days had no significant effect on the brain superoxide dismutase (SOD), catalase (CAT) activities. There was also no significant change in the levels of brain glutathione concentration (GSH), brain MDA, and behavioral parameters. Selenium nanoparticles also showed no significant alterations in brain biochemical parameters, behavioral effects, and brain histology. The oral administration of Selenium nanocomposites significantly increased brain superoxide dismutase, catalase, and reduced glutathione content and had positive effects on behavioral parameters.
Conclusion: The present study showed that Se -NCs have behavioral effects and could induce significant biochemical changes in brain oxidative status.
Molecular Epidemiology Study of Suspected Meningitis Cases in Tehran and Alborz Provinces
Authors: Mirjalili A , Mollazadeh SH 
Published: February 2022

Background and Objective: Meningitis is a medical emergency requiring immediate diagnosis and treatment. Bacterial and viral causative agents play a role in meningitis appearance to various degrees. Thus, effective vaccines and antimicrobial and supportive treatments need to be developed and monitoring should be performed in different regions for controlling this disease. Most previous studies have focused on a small number of bacterial agents, and the viral profile of this disease is not precisely monitored in Iran, especially in overpopulated regions. Moreover, limited new applied methods with high precision and sensitivity for the detection of meningitis agents indicate the necessity of determining meningitis agents by rapid molecular methods, which was the aim of the current study.
Materials and Methods: Overall, 148 samples obtained from suspected meningitis patients from different age groups admitted to Tehran and Karaj hospitals were evaluated by new methods involving specific primers for 16s rRNA, PCR, and Real-time PCR tests.
Results: It was found that viral infection, especially infection with human enterovirus, remains the main cause of meningitis in Iran, and Neisseria meningitides is the most common bacterial isolate detected in meningitis cases.
Conclusion: Despite the decreasing trend in meningitis incidence, according to World Health Organization recommendation, implementing an enhanced surveillance system to provide high-quality data on the epidemiological profile of meningitis per each region is necessary.
Assessing competence in teacher education: Development of university students’ problem-solving skills
Authors: Harangus Katalin 
Published: February 2022

In our research, we examined the development of complex problem-solving skills among 1st-year teachers training undergraduate students in engineering at Sapientia Hungarian University of Transylvania (N = 73). The research aimed to determine whether knowledge transfer works among students in interpreting life-like, specific problems. A worksheet was used as a measuring tool. In compiling it, we applied the concept that tasks include computer-transferable algorithms (such as cryptography process, parallel computing, and constraints), and their solution does not require any special IT knowledge, only structured and logical thinking. The research reports on the extent to which teacher training students have acquired knowledge and problem-solving strategies related to certain disciplines. The obtained data shed light on the fact that the lack of an interdisciplinary approach hinders the recognition of the connections between the different fields of education.

Keywords: Computational thinking; problem-solving skills; Teaching education.
Aching to be Understood: Vocational Rehabilitation Implications for Emerging Adults in Chronic Pain
Authors: Hunter Tameeka , Koch Lynn , Lusk Smith Stephanie , Hall Andrea Hampton 
Published: February 2022

BackgroundEmerging adults, the developmental period ranging from the late teens through the 20s, experience chronic pain at an estimated rate of 7.6%–14.3% and report greater pain interference (i.e., pain that disrupts daily life activities) than middle-aged or older adults. Chronic pain can interfere with the completion of developmental tasks associated with biological, psychological, occupational, and social changes necessary to move from emerging adulthood into young adulthood. For these reasons, the impact of chronic pain may be more detrimental for emerging adults than for middle-aged and older adults.ObjectiveTo investigate the unique characteristics and vocational rehabilitation needs of emerging adults with chronic pain and to identify and implement policies, practices, and interventions that facilitate the achievement of vocational rehabilitation consumer’s self-determined goals.MethodsThe authors reviewed the literature on (a) common conditions that cause chronic pain in emerging adults, (b) the populations most at risk of experiencing chronic pain in emerging adulthood, (c) psychosocial aspects of chronic pain for this population, (d) vocational impact of chronic pain on emerging adults, and (e) the use of the disability centrality model to guide assessment and planning.ConclusionThis literature review examines best practices related to vocational rehabilitation and emerging adults living with chronic pain. Comprehensive recommendations are provided that inform all phases of the vocational rehabilitation planning process, including services related to outreach and eligibility, counseling and guidance, physical and mental restoration, post-secondary education, job development and placement, and accommodation planning.
Studi Literatur: Digitalisasi Dunia Pendidikan dengan Menggunakan Teknologi Augmented Reality pada Pembelajaran Matematika
Authors: Khairunnisa Shafa , Aziz Tian Abdul 
Published: February 2022

Abstrak
Pandemi COVID-19 ini memberikan dampak negatif maupun positif bagi dunia pendidikan. Namun, dibalik dampak-dampak negatif yang ditimbulkan, terdapat dampak positif bagi dunia pendidikan, yaitu membangun lingkungan belajar digital di mana hal tersebut merupakan salah satu ciri dari era revolusi industri 4.0. Menanggapi era industri 4.0 dan masa pandemi ini, sudah saatnya bidang pendidikan memanfaatkan teknologi yang nantinya akan menjadikan kegiatan pembelajaran lebih efektif dan efisien, sehingga dapat menarik minat dan motivasi belajar peserta didik. Salah satu cara untuk membangun pendidikan di era industri 4.0 ini adalah dengan memanfaatkan teknologi sebagai media pembelajaran, salah satu teknologi yang dapat dimanfaatkan adalah teknologi Augmented Reality (AR). Penelitian ini memiliki tujuan, yaitu berusaha untuk menjelaskan apa dan bagaimana penggunaan teknologi AR, serta dampaknya dalam meningkatkan motivasi peserta didik. Metode penelitian ini menggunakan pendekatan kualitatif dan menerapkan metode penelitian studi kepustakaan atau biasa disebut dengan studi literatur (library research). Pada artikel ini diambil sumber-sumber berupa artikel yang berasal dari jurnal yang sudah terakreditasi Sinta, peneliti hanya membatasi dari Sinta 1 s.d. Sinta 4 dan jurnal yang sudah terakreditasi Scopus (Q1 s.d. Q3). Teknik analisis yang digunakan dalam penelitian ini adalah teknik analisis isi (content analysis). Didapatkan kesimpulan bahwa sistem teknologi Augmented Reality memiliki potensi untuk meningkatkan minat, motivasi, dan hasil dari suatu proses pembelajaran, khususnya pada pembelajaran matematika. Sistem pembelajaran yang ada di Indonesia belum sepenuhnya memanfaatkan teknologi sebagai suatu media pembelajaran, maka diperlukan upaya untuk membangun sistem pembelajaran dengan menggunakan teknologi, salah satu teknologi yang dapat digunakan adalah AR. Dengan menggunakan AR diharapkan motivasi belajar peserta didik akan semakin meningkat.
Barriers to COVID-19 Vaccine Uptake in the LGBTQIA Community
Authors: Azucar Danny , Slay Lindsay , Valerio Damaris Garcia , Kipke Michele D. 
Published: February 2022

Objectives. To report findings from qualitative research that describe sources of hesitancy and barriers to vaccine uptake among lesbian, gay, bisexual, transgender, queer, intersex, and asexual (LGBTQIA) populations. Methods. In March 2021, we conducted focus groups with members of the Los Angeles, California LGBTQIA community to identify barriers to becoming vaccinated. Semistructured interviews were conducted with 32 individuals in 5 focus groups. Thematic analysis was conducted to identify themes. Results. Historical and ongoing medical trauma, including misgendering, and perceived emotional violence emerged as significant barriers to LGBTQIA individuals becoming vaccinated. Fear of violence was found to be a major barrier among transgender individuals, whereas fear of an unwelcoming vaccination site was a barrier for seniors. Finally, surviving was a higher priority than becoming vaccinated. Conclusions. Participants reported vaccine hesitancy and barriers that are unique to the life experiences of LGBTQIA individuals; these include medical trauma, violence, stigma, and discrimination. Our findings highlight the need to include LGBTQIA leaders and trusted individuals in the development of vaccination education and the delivery of vaccination services. (Am J Public Health. 2022;112(3):405–407. https://doi.org/10.2105/AJPH.2021.306599 )
Norms and T-scores for Alcohol, Depression and Anxiety Screeners for The Population of Suriname
Authors: de Beurs Edwin , Jadnanansing Raj , Etwaroo Kajal , Blankers Matthijs , Bipat Robbert , Peen Jaap , Dekker Jack 
Published: February 2022

Abstract
Background: There is a considerable gap between care provision and the demand for care for common mental disorders in low-and-middle-income countries. Screening for these disorders, e.g., in primary care, will help to close this gap. However, appropriate norms and threshold values for screeners of common mental disorders are lacking. Methods: We gathered data on frequently used screeners for alcohol use disorders, depression, and anxiety disorders in a representative sample from Suriname, a non-Latin American Caribbean country. Results: We established cut-off values, normsNorms and crosswalk tables were established for the conversion of raw scores into a common metric: T-scores. Furthermore, recommended cut-off values on the T-score metric for severity levels were compared with international cut-off values for raw scores on these screeners. The appropriateness of these cut-offs and the value of converting raw scores into T-scores are discussed. Conclusion: Cut-off values help with screening and early detection of those who are likely to have a common mental health disorder and may require treatment. Conversion to a common metric simplifies the interpretation of test results.
Crossing the Cervicothoracic Junction During Posterior Cervical Laminectomy and Fusion for The Treatment of Multilevel Cervical Ossification of The Posterior Longitudinal Ligament
Authors: Wu Dong-Zhao , Gu Zhen-Fang , Meng De-Jing , Hou Shu-Bing , Ren Liang , Sun Xian-Ze 
Published: February 2022

Abstract
Purpose: The purpose of this study was to investigate the surgical efficacy of crossing the cervicothoracic junction during posterior cervical laminectomy and fusion for the treatment of multilevel cervical ossification of the posterior longitudinal ligament (OPLL).Methods: From October 2009 to October 2017, 46 consecutive patients with multilevel cervical OPLL underwent posterior cervical laminectomy and crossing the cervicothoracic junction fusion were obtained in the study. Their medical records were retrospectively collected. Cervical lordosis and cervical sagittal balance were used to assess radiographic outcomes. Japanese Orthopedic Association (JOA), axial symptom, C5 root palsy, blood loss, and operation time were used to assess clinical outcomes. The mean follow-up period was 20.7± 8.3 months.Results: The operation time was 205.2 ± 39.8 minutes and the intraoperative blood loss was 352.2 ± 143.7 ml. Analysis of the final follow-up data showed significant differences in JOA score (P<0.01), C2-C7 lordosis angle (P<0.01), and C2-C7 SVA (P<0.01). CT confirmed that grafted bone was completely fused in all patients and progression of OPLL was observed in two patients(4.3%) at final follow-up. No adjacent segment disease (ASD) or instrument failure occurred in any patients.Conclusions: Cervical laminectomy and crossing the cervicothoracic junction fusion are effective and safe methods to treat multilevel cervical OPLL. Randomized controlled studies with long-term follow-up are needed to confirm these results.