bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cesarean section per se is not a risk factor for non‐anatomical placenta creta
Authors: Stanek Jerzy 
Published: August 2022

AbstractObjectiveTo investigate whether mild forms of placenta creta (MPC) are more common in placentas delivered by cesarean section for non‐anatomical indications than in placentas from vaginal deliveries.MethodsThis is a retrospective clinical study in which MPC was diagnosed histologically by the presence of myometrial fibers in the decidua basalis or parietalis or in direct contact with the Rohr fibrinoid or chorionic villi. After excluding 111 cases at high risk for anatomical PC, placentas from 830 consecutive cesarean deliveries (group 1) were retrospectively statistically compared with 907 placentas from vaginal deliveries (group 2).ResultsStatistically significant differences were found in six independent clinical and seven placental phenotypes. More frequently, pre‐eclampsia, abnormal fetal heart rate tracing and umbilical artery Dopplers, hypercoiled umbilical cord, diffuse postuterine pattern of chronic hypoxic placental injury, and clusters of avascular or mineralized chorionic villi were found in group 1, while preterm delivery, induction of labor, and histological patterns related to stillbirth were observed in group 2.ConclusionMPC diagnosed in placentas from cesarean sections performed for non‐anatomical indications is not statistically significantly more common than in those after vaginal delivery. Therefore, MPC may feature similar diagnostic correlations and portend a similar prognosis for future pregnancies.
Reproducible and low‐power multistate bio‐memristor from interpenetrating network electrolyte design
Authors: Zhao Bin , Zhao Xuan , Li Qi , Xun Xiaochen , Ouyang Tian , Zhang Zheng , Kang Zhuo , Liao Qingliang , Zhang Yue 
Published: August 2022

AbstractBio‐memristor can address the inherent limitations of conventional memory components in artificial perceptual systems due to their biocompatibility with biological tissue. The actual deployment of bio‐memristor is restricted by the lack of reproducibility, high power consumption, and insufficient storage capacity. Here, a reproducible and low‐power multistate bio‐memristor is developed by designing the chitosan (CS)‐reduced graphene oxide (rGO) interpenetrating network electrolyte. The interpenetrating network structure of the CS‐rGO electrolyte reinforces structural stability and improves ionic conductivity. The bio‐memristor equipped with CS‐rGO active layer shows stable bipolar resistive switching up to 100 consecutive cycles, reproducible multistate storage with six different memory states, and low programming power of 9.4 μW. The fabricated biocompatible CS‐rGO device also exhibits deformation stability of memory operation over 103 bending cycles, high biocompatibility with HEK293 cells, and skin adhesion. This work provides an enlightening design strategy to develop high‐performance bio‐memristors for applications in artificial perceptual systems.image
Recent progress on the long‐term stability of hydrogen evolution reaction electrocatalysts
Authors: Zhai Wenfang , Ma Yuanyuan , Chen Dong , Ho Johnny C. , Dai Zhengfei , Qu Yongquan 
Published: August 2022

AbstractDeveloping new methodologies to produce clean and renewable energy resources is pivotal for carbon‐neutral initiatives. Hydrogen (H2) is considered as an ideal energy resource due to its nontoxic, pollution‐free, high utilization rate, and high calorific combustion value. Electrolysis of water driven by the electricity generated from renewable and clean energy sources (e.g., solar energy, wind energy) to produce hydrogen attracts great efforts for hydrogen production with high purity. Recently, the breakthrough of the catalyst activity limit for the hydrogen evolution reaction (HER) catalysts has received extensive attention. Comparatively, fewer reviews have focused on the long‐term stability of HER catalysts, which is indeed decisive for large‐scale electrolytic industrialization. Therefore, a systematic summary concentrated on the durability of HER electrocatalysts would provide a fundamental understanding of the electrocatalytic performance for practical applications and offer new opportunities for the rational design of the highly performed HER electrocatalysts. This review summarizes the research progress toward the HER stability of precious metals, transition metals, and metal‐free electrocatalysts in the past few years. It discusses the challenges in the stability of HER electrocatalysts and the future perspectives. We anticipate that it would provide a valuable basis for designing robust HER electrocatalysts.image
Robust triboelectric information‐mat enhanced by multi‐modality deep learning for smart home
Authors: Yang Yanqin , Shi Qiongfeng , Zhang Zixuan , Shan Xuechuan , Salam Budiman , Lee Chengkuo 
Published: August 2022

AbstractIn metaverse, a digital‐twin smart home is a vital platform for immersive communication between the physical and virtual world. Triboelectric nanogenerators (TENGs) sensors contribute substantially to providing smart‐home monitoring. However, TENG deployment is hindered by its unstable output under environment changes. Herein, we develop a digital‐twin smart home using a robust all‐TENG based information mat (InfoMat), which consists of an in‐home mat array and an entry mat. The interdigital electrodes design allows environment‐insensitive ratiometric readout from the mat array to cancel the commonly experienced environmental variations. Arbitrary position sensing is also achieved because of the interval arrangement of the mat pixels. Concurrently, the two‐channel entry mat generates multi‐modality information to aid the 10‐user identification accuracy to increase from 93% to 99% compared to the one‐channel case. Furthermore, a digital‐twin smart home is visualized by real‐time projecting the information in smart home to virtual reality, including access authorization, position, walking trajectory, dynamic activities/sports, and so on.image
“Plasma exchange in a bottle”: An overview of efgartigimod for apheresis practitioners
Authors: Tran Minh‐Ha 
Published: August 2022

AbstractEfgartigimod represents a first‐in‐class immunomodulatory agent that is comparable to TPE in reducing immunoglobulin levels. This translates to reductions in Myasthenia Gravis symptom scores with maximal effect following the fourth weekly efgartigimod dose. Efgartigimod received FDA approval in December of 2021 and may be an alternative particularly for patients on long‐term TPE regimens of weekly or less frequent. Apheresis practitioners, especially those managing long‐term apheresis in seropositive individuals, may therefore see some of their patients transitioned from plasma exchange to efgartigimod. Long‐term experience with efgartigimod remains lacking and studies are needed to establish the role of efgartigimod in the acute setting.
PARP1 inhibition enhances reactive oxygen species on gut microbiota
Authors: Zhuang Yixiao , Wang Hui , Ding Jiyang , Zhang Xinyi , Liu Xiaoyu , Zhang Shuai , Xing Xiaorui , Kaudimba Keneilwe Kenny , He Muyang , Zhang Shuang , Guo Shanshan , Kong Xingxing , Jin Li , Liu Tiemin 
Published: August 2022

AbstractPoly(ADP‐ribose) polymerase 1 (PARP1) plays a key role in genome stability by modulating DNA‐damage responses. Activated by DNA interruptions through ultraviolet (UV) exposure, PARylation is synthesized by PARP1 and serves as a survival mechanism for cancer and metabolic diseases. Several strategies including ROS and antimicrobial peptides (AMPs) function in host defenses, while the targeted tissue and mechanism under DNA damage are unknown. Here, we show that DNA damage induces responses specifically in the gut tissue. The knockdown of PARP1 reduces the activation of PARylation. Parp1 knockdown under DNA damage results in over‐accumulated ROS and secretion of AMPs through the regulation of Relish, a subunit of nuclear factor‐κB (NF‐κB). Double‐knockdown of Parp1 and Relish specifically in the gut inhibits AMP secretion. In conclusion, the host defense is achieved through ROS accumulation rather than the AMPs under DNA damage. In contrast, the knockdown of PARP1 exacerbates ROS accumulation to a harmful level. Under this circumstance, NF‐κb targeted AMP secretion is provoked for host defense. Microbiome and functional analysis provide evidence for the hazard of DNA damage and show variations in the metabolic pathways following Parp1 inhibition. Our findings suggest the notion that PARP1 inhibition contributes to ROS accumulation under DNA damage and its role in NF‐κb activation for host defense.
Involvement of Bid in the crosstalk between ferroptotic agent‐induced ER stress and TRAIL‐induced apoptosis
Authors: Kim Jin Hong , Najy Abdo J. , Li Jian , Luo Xu , Kim Hyeong‐Reh C. , Choudry Mohammad Haroon Asif , Lee Yong J. 
Published: August 2022

AbstractTumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) induces death receptor‐mediated extrinsic apoptosis, specifically in cancer cells, and Bid (BH3‐interacting domain death agonist) plays an important role in TRAIL‐induced apoptosis. Ferroptosis is a newly defined form of regulated cell death known to be distinct from other forms of cell death. However, our previous studies have shown that ferroptosis shares common pathways with other types of programmed cell death such as apoptosis. In this study, we investigated the role of Bid in the crosstalk between the ferroptotic agent‐induced endoplasmic reticulum (ER) stress response and TRAIL‐induced apoptosis. When human colorectal carcinoma HCT116 cells were treated with the ferroptosis‐inducing agents artesunate and erastin in combination with TRAIL, TRAIL‐induced activation of caspase‐8 was enhanced, and subsequently, the truncation of Bid was increased. Similar results were observed when ovarian adenocarcinoma OVCAR‐3 cells were treated with the ferroptotic agents in combination with TRAIL. Results from studies with Bid mutants reveal that the truncation of Bid and the presence of intact BH3 domains are critical for synergistic apoptosis. Nonfunctional Bid mutants were not able to activate the mitochondria‐dependent apoptosis pathway, which is required for the conversion of p19 to p17, the active form of caspase‐3. These results indicate that Bid plays a critical role in the crosstalk between the ferroptotic agent‐induced ER stress response and TRAIL‐induced apoptosis.
Optimizing medium composition with wastewater from Coffea arabica processing to produce single‐cell protein using Candida sorboxylosa
Authors: Pillaca‐Pullo Omar S. , Lopes André Moreni , Rodriguez‐Portilla Liz M.I. , Estela‐Escalante Waldir 
Published: August 2022

AbstractBackgroundCoffee production is an important agro‐industrial activity in several countries worldwide. However, during wet processing of coffee beans, substantial quantities of wastewater effluents are generated and discharged into nearby water systems, negatively impacting ecosystems. A compelling biotechnological alternative involves the use of nutrients contained in wastewater (e.g., sugars, proteins, and salts) to produce value‐added molecules–such as single‐cell protein (SCP) using the yeast Candida sorboxylosa–with high potential for use as animal feed.ResultsYeast isolated from the feces of ring‐tailed coatis showed a positive assimilation of reducing sugars (glucose, mannose, and fructose). Efficient reuse of coffee wastewater (CWW) for SCP production was achieved via the statistical design of experiments (DoE) technique. The bioprocess was standardized in a medium culture composed of 87.5% (v/v) CWW, and of 1.38 and 7.24 g/L yeast extract (YE) and ammonium sulfate [(NH4)2SO4], respectively, resulting in a high SCP yield of approximately 38%.ConclusionThe reuse of CWW shows potential as a low‐cost component for SCP production that can ultimately reduce the environmental impact of wastewater effluent by circumventing its release into river systems. The bioprocess developed in this study presented certain advantages, including high volumes of CWW with only YE and (NH4)2SO4 supplementation, and without requiring additional components to correct the pH of the medium. Therefore, it is highly feasible to apply this bioprocess in close proximity to coffee‐processing agrobusinesses, thus generating an alternative source of income for Peruvian coffee‐producing communities. © 2022 Society of Chemical Industry (SCI).
Proposal of nomograms to predict clinical outcomes in patients with ampulla of Vater cancer based on the Korea‐Japan collaborative study
Authors: Kim Hyung Sun , Kim Woojin , Endo Itaru , Jang Jin‐Young , Kim Hongbeom , Song Ki Byung , Hwang Dae Wook , Kang Chang Moo , Hwang Ho Kyoung , Park Sang‐Jae , Han Sung‐Sik , Yoon Yoo‐Seok , Do Yang Jae , Amano Ryosuke , Yamazoe Sadaaki , Yanagimoto Hiroaki , Ajiki Tetsuo , Ohtsuka Masayuki , Suzuki Daisuke , Lee Dong‐Shik , Kitahata Yuji , Amaya Koji , Sakata Jun , Seo Hyung Il , Yamauchi Junichiro , Yabushita Yasuhiro , Tanaka Takayuki , Sakurai Naoki , Hirashita Teijiro , Horiguchi Akihiko , Unno Michiaki , Do You Dong , Yamashita Yo‐ichi , Kobayashi Shogo , Kyoden Yusuke , Ide Takao , Nagano Hiroaki , Nakamura Masafumi , Yamaue Hiroki , Yamamoto Masakazu , Park Joon Seong 
Published: August 2022

AbstractBackgroundIn this study, we aimed to develop and validate a nomogram to predict overall survival (OS) and recurrence‐free survival (RFS) in patients who underwent curative resection of ampulla of Vater (AOV) cancer. This is the first study for nomograms in AOV cancer patients using retrospective data based on an international multicenter study.MethodsA total of 2007 patients with AOV adenocarcinoma who received operative therapy between 2002 January and 2015 December in Korea and Japan were retrospectively assessed to develop a prediction model. Nomograms for 5‐year OS and 3‐year RFS were constructed by dividing the patients who received and who did not receive adjuvant therapy after surgery, respectively. Significant risk factors were identified by univariate and multivariate Cox analyses. Performance assessment of the four prediction models was conducted by the Harrell’s concordance index (C‐index) and calibration curves using bootstrapping.ResultsA total of 2007 and 1873 patients were collected for nomogram construction to predict 5‐year OS and 3‐year RFS. We developed four types of nomograms, including models for 5‐year OS and 3‐year RFS in patients who did not receive postoperative adjuvant therapy, and 5‐year OS and 3‐year RFS in patients who received postoperative adjuvant therapy. The C‐indices of these nomograms were 0.795 (95% confidence interval [CI]: 0.766‐0.823), 0.712 (95% CI: 0.674‐0.750), 0.804 (95% CI: 0.7778‐0.829), and 0.703 (95% CI: 0.669‐0.737), respectively.ConclusionsThis predictive model could help clinicians to choose optimal treatment and precisely predict prognosis in AOV cancer patients.
Expansion of the clinical and neuroimaging spectrum associated with NDUFS8‐related disorder
Authors: Andzelm Milena M. , Balasubramaniam Shanti , Yang Edward , Compton Alison G. , Millington Kate , Zhu Jia , Anselm Irina , Rodan Lance H. , Thorburn David R. , Christodoulou John , Srivastava Siddharth 
Published: August 2022

AbstractBiallelic pathogenic variants in NDUFS8, a nuclear gene encoding a subunit of mitochondrial complex I, result in a mitochondrial disorder characterized by varying clinical presentations and severity. Here, we expand the neuroimaging and clinical spectrum of NDUFS8‐related disorder. We present three cases from two unrelated families (a girl and two brothers) homozygous for a recurrent pathogenic NDUFS8 variant [c.460G>A, p.(Gly154Ser)], located in the [4Fe‐4S] domain of the protein. One of the patients developed auto‐antibody positive diabetic ketoacidosis. Brain MRIs performed in two of the three patients demonstrated diffuse cerebral and cerebellar white matter involvement including corticospinal tracts, but notably had sparing of deep gray matter structures. Our report expands the neuroimaging phenotype of NDUFS8‐related disorder to include progressive leukodystrophy with increasing brainstem and cerebellar involvement, with relative sparing of the basal ganglia. In addition, we describe autoimmune diabetes in association with NDUFS8‐related disorder, though the exact mechanism of this association is unclear. This paper provides a comprehensive review of case presentation and progressive neuroimaging findings of three patients from two unrelated families that have an identical pathogenic NDUFS8 variant, which expands the clinical spectrum of NDUFS8‐associated neurological disease.
Intraspecific variation in the cranial osteology of Diplometopon zarudnyi (Squamata: Amphisbaenia: Trogonophidae)
Authors: Hawkins Rebecca K. , Bell Christopher J. , Olori Jennifer C. , Stocker Michelle R. 
Published: August 2022

AbstractA snake‐like body plan and burrowing lifestyle characterize numerous vertebrate groups as a result of convergent evolution. One such group is the amphisbaenians, a clade of limbless, fossorial lizards that exhibit head‐first burrowing behavior. Correlated with this behavior, amphisbaenian skulls are more rigid and coossified than those of nonburrowing lizards. However, due to their lifestyle, there are many gaps in our understanding of amphisbaenian anatomy, including how their cranial osteology varies among individuals of the same species and what that reveals about constraints on the skull morphology of head‐first burrowing taxa. We investigated intraspecific variation in the cranial osteology of amphisbaenians using seven individuals of the trogonophid Diplometopon zarudnyi. Variation in both skull and individual skull element morphology was examined qualitatively and quantitatively through three‐dimensional (3D) models created from microcomputed tomography data. Qualitative examination revealed differences in the number and position of foramina, the interdigitation between the frontals and parietal, and the extent of coossification among the occipital complex, fused basioccipital and parabasisphenoid (“parabasisphenoid‐basioccipital complex”), and elements X. We performed 3D landmark‐based geometric morphometrics for the quantitative assessment, revealing shape differences in the skull, premaxilla, maxilla, frontal, and parietal. The observed intraspecific variation may be the result of different stages of ontogenetic development or biomechanical optimization for head‐first burrowing. For example, variation in the coossification of the occipital region suggests a potential ontogenetic coossification sequence. Examination of these areas of variation across other head‐first burrowing taxa will help determine if the variation is clade‐specific or part of a broader macroevolutionary pattern of head‐first burrowing.
MRI‐Based Artificial Intelligence in Rectal Cancer
Authors: Wong Chinting , Fu Yu , Li Mingyang , Mu Shengnan , Chu Xiaotong , Fu Jiahui , Lin Chenghe , Zhang Huimao 
Published: August 2022

Rectal cancer (RC) accounts for approximately one‐third of colorectal cancer (CRC), with death rates increasing in patients younger than 50 years old. Magnetic resonance imaging (MRI) is routinely performed for tumor evaluation. However, the semantic features from images alone remain insufficient to guide treatment decisions. Functional MRIs are useful for revealing microstructural and functional abnormalities and nevertheless have low or modest repeatability and reproducibility. Therefore, during the preoperative evaluation and follow‐up treatment of patients with RC, novel noninvasive imaging markers are needed to describe tumor characteristics to guide treatment strategies and achieve individualized diagnosis and treatment. In recent years, the development of artificial intelligence (AI) has created new tools for RC evaluation based on MRI. In this review, we summarize the research progress of AI in the evaluation of staging, prediction of high‐risk factors, genotyping, response to therapy, recurrence, metastasis, prognosis, and segmentation with RC. We further discuss the challenges of clinical application, including improvement in imaging, model performance, and the biological meaning of features, which may also be major development directions in the future.Evidence Level5Technical EfficacyStage 2
Risk Factors for Fear of Recurrence in Head and Neck Cancer Patients
Authors: Riggauer Julia , Blaser Daniela , Elicin Olgun , Gahl Brigitta , Giger Roland , Mueller Simon Andreas 
Published: August 2022

ObjectiveFear of recurrence (FoR) affects the quality of life of head and neck cancer survivors. Identification of factors predisposing to FoR may help to recognize and treat patients at risk.Materials and MethodsFor this exploratory study, 101 disease‐free head and neck cancer survivors completed a cross‐sectional survey in 2017 that included the FoR questionnaire at a random point in time during their follow‐up. Additionally, the patients were asked to choose their favorite among four follow‐up schedules with or without systematic imaging and varying frequency of visits.ResultsElevated FoR was present in 36.6% of patients. Females and patients ≤65 years showed significantly higher FoR overall scores than males (score difference 3.40; CI 0.49–6.32; p = 0.022) and patients >65 years (score difference 4.25; CI 1.58–6.92; p = 0.002). A history of cancer recurrence or second primary malignancy increased the relative risk (RR) for elevated FoR (RR 1.7; CI 1.01–2.86; p = 0.046). Tumor stage and treatment modality were not significantly associated with elevated FoR or FoR overall score. Higher FoR overall scores were recorded in patients who favored intensive follow‐up plans (mean overall FoR score 18 vs. 15; SD 7.7; p = 0.076) and systematic imaging in follow‐up (17 vs. 13, SD 7.1; p = 0.034).ConclusionFear of recurrence in head and neck cancer patients is associated with female sex, younger age, and history of a past recurrence or second primary malignancy. Due to its high prevalence, it should be addressed in clinical practice and future research.Level of EvidenceNA Laryngoscope, 133:1630–1637, 2023
Retrograde Cricopharyngeus Dysfunction: The Jefferson Experience
Authors: Siddiqui Sana H. , Sagalow Emily S. , Fiorella Michele A. , Jain Nikhita , Spiegel Joseph R. 
Published: August 2022

ObjectivesTo describe our center's experience with the identification and treatment of retrograde cricopharyngeus dysfunction (R‐CPD), a syndrome involving the inability to belch previously described by only one institution. Additionally, because all patients initially learned of their condition and sought treatment as a result of social media posts, we queried their source and comfort with this form of medical referral.MethodsRetrospective chart review of patients who underwent botulism toxin injection into the cricopharyngeus muscle for treatment of R‐CPD from 2019 to 2022. Demographic data, most common symptoms at presentation, and response to treatment and complications were documented. Post‐treatment questionnaires were reviewed.ResultsA total of 85 patients were identified. Mean age at surgery was 27 years. There were 54 (63.5%) females and 31 (36.5%) males. The inability to burp (98.8%), bloating (92.9%), gurgling noises (31.8%), and excessive flatulence (21.2%) were the most common symptoms. The minimum units of botox utilized were 25, whereas the maximum was 100. The majority of patients (88.2%) had a successful response at initial follow‐up visit. The most common complication was mild dysphagia (30.6%), which was transient for all patients. Most patients learned of our practice through social media, with only one patient being referred by a medical provider.ConclusionsThe majority of patients in our cohort were young and female. The inability to burp and bloating were the most common presenting symptoms. Social media was the primary source of referral. Our institution favors 80–100 units for an effective response. Laryngoscope, 133:1081–1085, 2023