bluuebunny/crossref_metadata_2025_split huggingface dataset:
The study of Overexpression of Peroxiredoxin-2 Reduces MPP+-Induced Toxicity in SH-SY5Y Neuroblastoma Cells
Authors: Liu Menghao , Zuo Shuqian , Guo Xing , Peng Junyu , Xing Yaoping , Guo Yanjie , Li Chaokun , Xing Hongxia 
Published: November 2022

Abstract
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss. Excessive reactive oxygen species (ROS) accumulation has been implicated in the pathogenesis of Parkinson’s disease. Endogenous Peroxiredoxin-2 (Prdx-2) has potent anti-oxidative and anti-apoptotic effects. For further study of the activation of Prdx-2 and its role in vitro, SH-SY5Y cells were treated with MPP+ or transfected with Prdx-2. The results showed that MPP+ raises intracellular ROS, depolarizes mitochondrial membrane potential, decreases cell activity, and reduces expression of tyrosine hydroxylase (TH), Prdx-2, Silent Information Regulator of Transcription 1 (SIRT1), and increases the proapoptotic/anti-apoptotic expression ratio (Bax/Bcl2). When cells were transfected with Prdx-2, TH and SIRT1 were increased, the Bax/Bcl-2 ratio was decreased, ROS content was decreased, and cell activity was enhanced. However, this study not directly test whether Prdx-2 affects the downstream signaling factors of SIRT1.This will be the focus of the next stages of research.
Sistem Pendukung Keputusan Pemilihan Duta Pelajar IPNU IPPNU Menggunakan Metode Simple Additive Weighting (SAW)
Authors: Mawarda Ella , Mahendra Danang , Akbar Agus Subhan 
Published: November 2022

IPNU IPPNU merupakan organisasi pelajar di bawah naungan Nahdlatul Ulama (NU). Untuk menigkatkan pemahaman keaswajaan, Ke-NU-an, keorganisasian, dan kebangsaan, IPNU IPPNU membuat sebuah program yang bernama pemilihan duta IPNU IPPNU tingkat kabupaten. Proses pemilihan duta pelajar ini masih dilakukan secara manual, sehingga membuat proses pemilihan kurang efektif dan efisien, serta unsur subjektivitas masih sangat tinggi. Dalam makalah ini, penulis mengusulkan sebuah sistem pendukung keputusan untuk pemilihan duta pelajar. Sistem ini menggunakan metode Simple Additive Weighting (SAW) yang melakukan perhitungan dengan menentukan nilai bobot terlebih dahulu dari setiap kriteria, kemudian melakukan proses perhitungan untuk mendapatkan alternatif yang paling sesuai dengan kriteria. Aplikasi diujicobakan kepada panitia pemilihan duta pelajar untuk mengevaluasi kinerjanya. Berdasarkan black box testing dapat disimpulkan bahwa sistem yang dibangun dapat berfungsi dengan baik.
Determination of Thrombin Activity by Reversed-phase High Performance
Liquid Chromatography
Authors: Zhang Liang , Yang Dehui , Liu Ye 
Published: November 2022

Background:
A reversed-phase high-performance liquid chromatographic method for
determining thrombin activity is described. The improved method can provide a high resolution
between substrate Nα-P-toluenesulfonyl-L-arginine methyl ester (TAME) and the product of enzyme
reaction, Nα-P-toluenesulfonyl-L-Arginine (TA).

Methods:
When the substrate concentration was 5 mg/mL, the Michaelis equation approached the
zero-order reaction, and the thrombin enzyme activity must have a good linear relationship with
the consumption of TAME or the yield of TA.

Results:
The method is suitable for quantitatively analyzing thrombin activity in formulation or
serum.

Conclusion:
Three batches of thrombin lyophilized preparations were determined for activity.
Investigation of Chemical Constituents of Chamaenerion latifolium L.
Authors: Iskakova Zhanar , Kozhantayeva Akmaral , Tazhkenova Gaukhar , Mashan Togzhan , Tosmaganbetova Kuldi , Tashenov Yerbolat 
Published: November 2022

Background:
Chamaenerion latifolium is a perennial herbaceous plant of the Onagraceae
family. The purpose of this study was to evaluate and compare the volatile chemical components
of the aerial parts of Chamaenerion latifolium growing in the Republic of Kazakhstan.

Method:
The leaves and stems of Chamaenerion latifolium were extracted with hexane and analysed
by gas chromatography-mass spectrometry (GC-MS).

Results:
The regularisation of peak areas method was used to calculate the concentrations of the
sixty-five identified compounds.

Conclusion:
Among them, the major components are alkanes (leaves 31.339%, stems 48.158%),
esters (leaves 10.216%, stems 12.196%), alcohols (leaves 5.483% and stems 5.14%), aldehydes
(leaves 3.155%, stems 1.592%), triterpenoids (leaves 2.247% stems 3.785%).
Population vs. Intersection Densities: An Assessment of a Correlation Using Spatial Comparison and Regression Analysis in Yaoundé, Cameroon
Authors: Essola Edouard Bengono , Yeom Chunho 
Published: November 2022

Background:
Intersection density is associated with block size and positively affects pedestrian volume.

Objective:
This study aimed to show that intersection density and population match across Yaoundé using spatial comparison and regression analysis.

Methods:
For spatial comparison, the mean values of the variables (intersection and population densities) were computed for each administrative subdivision in Yaoundé. The results are reported in a table representing Yaoundé and how the subdivisions share boundaries. For comparison, a table was created for each variable. Simple linear regression with a confidence level of 95% was used for regression analysis.

Results:
Spatial analysis revealed that the pattern of population density was similar to that of intersection density. However, this was disturbed by the proximity to the central business district (CBD). Regression analysis demonstrated that both variables moderately covariate with the influence of CBD. When assuming a weak influence of CBD, they are strong covariates. Statistically, in both cases, the correlation between population and intersection densities did not occur randomly (small p-values).

Conclusion:
The results imply that intersection density is a strong lever that influences citizen behavior. Future planning policies in Yaoundé should consider increasing intersection density in the most crowded areas. It will contribute to the better management of high pedestrian flows in these areas.
The Status of Integrating Children and Adolescents’ Mental Health Care Services into Primary Health Care in South Africa: Scoping Review
Authors: Mokgaola Isaac O , Gause Gopolang , Sehularo Leepile A , Molato Boitumelo J , Meno Omphemetse F , Sepeng Nombulelo V 
Published: November 2022

Background:
Many children and adolescents who need mental health care services in South Africa find it difficult to access these services. The PHC approach is the foremost strategy adopted by the South African government to improve access to health care services in the country. Therefore, the integration of children and adolescents mental health care services into primary health care should greatly improve access.

Objective:
The objective of this review is to describe and interrogate the status of integrating children and adolescents’ mental health care services into primary health care in SA.

Methods:
The scoping literature review was conducted following the framework of identifying the research question, identifying relevant studies, selecting studies, charting data, and finally collating, summarising, and synthesising the results. The databases used are APA, PsychINFO, Medline, Cabinet Discover, and Africa-Wide Informatio. Thematic analysis was used to qualitatively analyse the findings of the studies reviewed.

Results:
Six studies were selected for inclusion in this research. The analysis yielded three themes : challenges to integrating child and adolescent mental health care, services into primary health care, the need for health care systems to enable integration of child and adolescent mental health services into primary health care, and the lack of child and adolescent mental health care services.

Conclusion:
The integration of child and adolescent mental health care services into primary health care in South Africa is far from realisation. Recommendations are made for practice, education, and research.
Valorization of Algerian Semi-Soft Date and Traditional Preparation of Date Syrup: Physicochemical and Biochemical Properties
Authors: Laouar Asma , Benbelkhir Amina , Baida Wahiba , Rouissat Linda , BENYAGOUB Elhassan 
Published: November 2022

In Algeria, the production of dates occupies a large part of Saharan agricultural production. The wilaya of Bechar is one of the most productive regions for dates, where more than half of their production is considered as a second quality dates which are sold by barter or used as animal feed. Families in these regions use this type of date to prepare by-products, namely; date syrup locally called "Robb". The preparation of this type of product is limited and confined to the individual scale. The aim of this study is to highlight the physicochemical and the biochemical quality of this home-prepared artisanal product by comparing it to two others marketed in the wilaya of Béchar and of Elbayadh (Algeria).
The physicochemical and the biochemical results of the three analyzed samples showed an acidic pH value ranged from 4,26 to 4,7, a degree of acidity ranging from 8,2 to 12%, a soluble solids content of 64 to 75%, a total sugars and reducing sugar content of 51 to 63,6 and 40 to 52% respectively. While the water content is relatively high ranging from 28 to 37%, and a significant potassium ions content compared to sodium ions varies from 195 to 555 and from 5,8 to 137mg/L respectively.
These characteristics are not only considered as a high added value to the product which enhances the value of the second-quality low marketing dates but also contributes to increasing their shelf life, constituting an economic priority for the oasis’ inhabitants of the Southern Algeria region.
Penyelesaian Tindak Pidana Penganiayaan yang Dilakukan oleh Anak Melalui Diversi
Authors: Annisa Syarah , Sudarti Elly 
Published: November 2022

This article aims to find out the settlement of criminal acts of abuse committed by children through diversion at the Kerinci Police and the obstacles faced in the settlement of criminal acts of abuse committed by children through diversion at the Kerinci Police. This research uses empirical juridical method. Research results In the first case Police Report: LP/B-159/VIII/2020/SPKT.1/RES KERINCI. In the settlement that was resolved by diversion, an agreement was reached and was successful and in accordance with the rules in Article 7 paragraphs 1 and 2 of Law Number 11 of 2012 concerning the Juvenile Criminal Justice System. In the results of the diversion agreement Number: 03/HDK/XII/2020/RESKRIM dated December 03, 2020 In the second case the Police report: Number: B/58/II/Res.1.8/2021 In the settlement that was resolved by diversion, no agreement was reached. Through the results of the diversion agreement Number: 01/HKD/II/Res.1.8/2021 dated October 18, 2021. Obstacles faced in resolving criminal acts of abuse committed by children through diversion at the Kerinci Police, namely in solving cases there are difficulties during the investigation and in uniting thoughts between the victim and the child in conflict with the law so that an agreement can be reached and the issue can be resolved and not resolved.

ABSTRAK
Artikel ini bertujuan untuk mengetahui penyelesaian tindak pidana penganiayaan yang dilakukan oleh anak melalui diversi di Polres Kerinci dan kendala yang dihadapi dalam penyelesaian tindak pidana penganiayaan yang dilakukan oleh anak melalui diversi di Polres Kerinci. Penelitian ini menggunakan metode yuridis empiris. Hasil penelitian Pada kasus pertama Laporan Polisi: LP/B-159/VIII/2020/SPKT.1/RES KERINCI. Di dalam penyelesaian yang diselesaikan secara diversi telah tercapai kesepakatan dan berhasil dan sesuai dengan aturan di dalam Pasal 7 ayat 1 dan 2 Undang-Undang Nomor 11 Tahun 2012 Tentang Sistem Peradilan Pidana Anak. Pada hasil kesepakatan diversi Nomor: 03/HDK/XII/2020/RESKRIM tanggal 03 Desember 2020 Pada kasus kedua laporan Polisi: Nomor: B/58/II/Res.1.8/2021 Di dalam penyelesaian yang diselesaikan secara diversi tidak tercapai kesepakatan. Melalui hasil kesepakatan diversi Nomor: 01/HKD/II/Res.1.8/2021 tanggal 18 Oktober 2021. Kendala yang dihadapi penyelesaian tindak pidana penganiayaan yang dilakukan oleh anak melalui diversi di Polres Kerinci yakni pada penyelesaian kasus terdapat kesulitan pada saat penyelidikan dan dalam mempertemukan mereka yang berkonflik dengan hukum agar tercapainya kesepakatan persoalan tersebut dapat diselesaikan dan tidak terselesaikan.
Significantes ambiguos de la libertad. La reflexión sobre el sexo, el destape y la pornografía en Vindicación feminista (1976-1979)
Authors: Ardid Carmen Peña 
Published: November 2022

Abstract
La explotación visual del cuerpo femenino erotizado que prolifera durante la Transición política española en el cine, el teatro y las revistas ilustradas con el popular nombre de destape, fue acogida con aplauso en muchos círculos progresistas o simplemente liberales del país. El acceso legitimado a excitantes desnudos femeninos se identificó con la liberación sexual, tras muchos años de represión franquista, y se convirtió en un símbolo de la conquista de las libertades democráticas. Este artículo analiza el modo en que, desde las páginas de Vindicación feminista, órgano clave del feminismo español en la Transición, se cuestionó este ideario, al sacar a la luz el profundo (hetero)sexismo de las manifestaciones del destape y denunciarlas como un nuevo modo de control de la sexualidad de las mujeres; un control que se añadía al sometimiento social, jurídico, médico y religioso heredado del orden franquista y aún no desmantelado. Lejos de la censura moral, sus análisis enfocan la exhibición de cuerpos femeninos en el marco de un continuum sexista que en la cultura heteropatriarcal de Occidente extiende su dominio desde las imágenes publicitarias de belleza a la pornografía.
María Teresa León
Authors: Purkey Lynn C. 
Published: November 2022

Abstract
This article examines León’s rewriting of two Castilian legends through a feminist reading of Bakhtin, which demonstrates the narratives’ capacity to deconstruct patriarchy and create multiple points of view. Doña Jimena Díaz de Vivar resurrects the voice of the Cid’s wife, whose role in history was eclipsed by her larger-than-life husband, while La bella del mal amor challenges the double standard and status quo of the romancero tradition. Both serve as a window into women’s lives in the past, while exploring issues that still resonate today.
Trends in prescriptions of cardio-protective diabetic agents after coronary artery bypass grafting among US Veterans
Authors: Deo Salil V , McAllister David A , Al-Kindi Sadeer , Elgudin Yakov , Chu Danny , Pell Jill , Sattar Naveed 
Published: November 2022

<p> </p>
<p>Introduction: Patients with type 2 diabetes mellitus (T2DM) undergoing coronary artery bypass grafting (CABG) are at risk of cardiovascular events. SGLT2i and GLP-1RA are effective cardio-protective agents, however, their prescription among CABG patients is uncertain.</p>
<p>Methods: We analyzed the nationwide Veteran Affairs database (2016 – 2019) to report trends and factors associated with SGLT2i or GLP1RA prescription after CABG. </p>
<p>Results: Among 5,109 patients operated at 40 different VA medical centers, 525/5109 (10.4%), 352/5109 (6.8%) and 91/5109 (1.8%) were prescribed SGLT2i, GLP-1RA and both respectively. Substantial increase in the quarterly SGLPT2i prescription rates (1.6% (2016Q1), 33% (2019Q4)) was present; less so for GLP-1RA (0.8% (2016Q1), 11.2% (2019Q4)). SGLT2i use was less likely with pre-existing vascular disease (OR 0.75-95%CI-[0.75,0.94]) or kidney disease (OR 0.72-95%CI-[0.58,0.88]), while GLP-1RA use was associated with obesity (OR 1.91-95%CI-[1.50,2.46]). </p>
<p>Conclusion: The overall utilization of SGLT2i or GLP-1RA drugs in US Veterans with T2DM undergoing CABG is low, with SGLT2i preferred over GLP-1RA. </p>
A grammatical analysis of harf "Bal" and its meanings in the Holy Qur'an / Diraasatun Tahliiliyyatun Nahwiyyatun an Harfi “Bal” wa Ma’aaniiha fi al-Qur’ani al Kariim
Authors: Rambe Pangadilan , Nasution Halomoan 
Published: November 2022

القرآن معجزة كبرى لرسول الله صلى الله عليه وسلم و هدى للناس. والقرآن ومعناه من عند الله عز وجل وله أساليب تحتمل معجزة وتراكيب رائعة أكبر من أساليب اللغة العربية في الزمن الحاضر. ولفهم القرآن،يحتاج المسلم إلى استيعاب علوم اللغة العربية وخاصة علم النحو ومن ماداته حرف "بل". وأما موضوع هذا البحث فهو الأيات الضامنة حرف "بل"الموجودة في القرآن الكريم التي عددها مائة وواحد وعشرون أية. في هذه الصحيفة، يستخدم الكاتب المصدر التمهيدي والثانوي الذين يتعلقان بموضوع البحث. وطريقة تحليل البيانات المستخدمة هي الطريقة التحليلية النحوية وتحليل مضمون الكتب. هذه الصحيفة تهدف إلى معرفة أنواع حرف "بل" فى القرآن الكريم ومعانيه.
Clinical features, outcomes, and long-term survival times of cats and dogs with central nervous system cryptococcosis in Australia: 50 cases (2000–2020)
Authors: Jacobson Else , Morton John M. , Woerde Dennis J. , Thompson Mary F. , Spillane Amanda M. , Tebb Anna , della Valle Zoe , Birnie Gemma , Malik Richard 
Published: November 2022

Abstract

OBJECTIVE
To describe the clinical findings and outcomes of Australian cats and dogs with CNS cryptococcosis.

ANIMALS
19 cats and 31 dogs with CNS cryptococcosis diagnosed between 2000 and 2020.

PROCEDURES
A case series and cohort study were performed using the same 50 animals. Both studies were multi-institutional and both retrospective and prospective. Disease features were compared between cats and dogs, and associations between putative risk factors and survival time (ST) were assessed.

RESULTS
Dogs were younger at initial presentation than cats and had lower latex cryptococcal antigen agglutination titers. Extraneurologic signs were common and frequently involved sinonasal and contiguous tissues. Neuroanatomic localization was predominantly forebrain, central vestibular (including cerebellum), multifocal, or diffuse. CSF analysis predominantly showed pleocytosis, with eosinophilic inflammation common in dogs. Seventy-eight percent (39/50) of patients received antifungal treatment. Median STs (from presentation) in treated patients were 1,678 days for cats and 679 days for dogs. Abnormal mentation at presentation (in dogs) and CSF collection (in cats) were associated with shorter STs. In treated dogs, those that received glucocorticoids prior to diagnosis, or single rather than multiple antifungal agents, had shorter STs.

CLINICAL RELEVANCE
The prognosis for feline and canine CNS cryptococcosis is guarded, yet long STs are possible with appropriate treatment. Presence of subtle upper respiratory tract signs may suggest cryptococcosis in patients with neurologic signs, while the absence of neurologic signs does not preclude CNS involvement.
Experimental Study of Thermal Conductivity of Concrete with Biosourced Material for Saved Energy in Buildings
Authors: Necib Hichem , Belatrache Djamel , Goutar Hafnaoui , Sahraoui Nesrine 
Published: November 2022

Abstract
This study aims to improve the thermal efficiency of concrete slabs by introducing a plant material. This can contribute to the improvement of internal thermal comfort for buildings and this by lower energy consumption. For this, several experiments were carried out at the laboratory, to find the thermal properties of a new innovative building material produced by inserting ALFA (STIPA TENACISSIMA) into a concrete slab. Several mass percentages of ALFA relative to the total mass of the concrete slab (0%, 0.4%, 0.8%, 1.2% and 1.6%) were studied to see the effect of the introduced quantity of this plant on the thermal conductivity of concrete. It was concluded that the insertion of ALFA in the concrete, decreases considerably the thermal conductivity. The best results are noticed for 1.2% of ALFA, whose thermal conductivity of the concrete is reduced up to 50.61%. As a result, heat gains and losses, through wall or slab, are significantly reduced, which reduces the energy consumed by cooling and heating of homes. In addition, the degree-day method was used to calculate the costs of cooling and heating energy for 58 regions in Algeria. The lowest total energy cost is noticed in the TENES region, while the highest energy cost is noticed in the BORDJ B. MOKHTAR region.
Introduction
Authors: Cadilha Susana , Guerreiro Vítor 
Published: November 2022

Abstract
We present the structure and guiding principles of this Special Issue, with a brief description of the participants’ contributions and the relations holding between them. The intersection between aesthetics and ethics as a field of philosophical enquiry is presented under the guise of a ‘layer cake’: at the top layer we find the most general metaphysical and epistemological issues concerning the nature of value, aesthetic and ethical; the middle layer encompasses several normative issues about the interactions of aesthetic, moral and cognitive values in art; finally at the bottom layer we introduce issues of a more restricted focus, like the aesthetic peculiarity of political songs and the ethics of artistic appropriation.
Islamic Context on PISA-Like Mathematics Problem in Junior High School
Authors: Nizar Harisman , Putri Agustiany Dumeva , Septy Liana 
Published: November 2022

This research was motivated by the low achievement of Indonesian students in the assessment of PISA problems and the Islamic context that is familiar to students. The purpose of this research was to produce valid and practical PISA-like mathematics problems using Islamic context in junior high school and to find out the potential effect of the problem on mathematical literacy ability. The subjects of this study were students of the Ninth grade in one of Junior High School, in South Sumatera, Indonesia. Furthermore, the methodology used was design research with the type of development study. The validity was obtained based on the assessment of the validator (expert) regarding the content, construct, and language used and student work in the one-to-one phase. Meanwhile, the practicality can be seen from the work of students in the small group phase where students can understand the meaning or language of the questions. Furthermore, the potential effect can be seen from the strategy of students in working on the questions during the field test. In this case, the potential effects that arise were mathematical communication ability, mathematical representation ability, and ability of devising strategies for solving problems, as well as mathematization ability.
Edukasi Penentuan Harga Jual Produk UMKM melalui Perhitungan Harga Pokok Produksi
Authors: Sayadi Muhammad Hamdan 
Published: November 2022

Kegiatan ini bertujuan melakukan pendampingan perhitungan harga pokok produksi yang dijadikan pertimbangan utama dalam penentuan harga jual produk. Kegiatan ini akan dilakukan dengan mitra yang fokus pada penjualan produk deodoran spray rumahan. Kegiatan ini dilaksanakan pada bulan Mei – Juni 2021. Beberapa hal yang menjadi permasalahan mitra antara lain, belum pernah menghitung harga pokok produksi, penentuan harga jual produk hanya menggunakan asumsi pribadi, tidak diketahui apakah harga jual produk diatas atau dibawah harga pokok produksi. Langkah pertama melakukan perhitungan biaya yang dikeluarkan untuk mendapatkan bahan baku sebagai bahan untuk membuat produk deodoran. Langkah selanjutnya melakukan perhitungan biaya yang digunakan untuk membuat deodoran selain biaya bahan baku langsung. Kesalahan dalam perhitungan harga pokok produksi akan mengakibatkan kesalahan dalam menentukan harga jual. Awal mula kerugian suatu bisnis berawal dari kesalahan dalam menentukan harga jual. Mitra selama ini melakukan perhitungan hanya berdasarkan harga perkiraan dalam menentukan harga jual produk deodoran spray ukuran 60 dan 100ml. Mitra tidak mengetahui cara menentukan harga yang akan digunakan sebagai dasar produk untuk dijual. Dapat disimpulkan bahwa selama ini mitra tidak mengetahui dengan pasti harga pokok produksi untuk membuat sebuah produk deodoran spray baik ukuran 60ml dan 100ml. Setelah kegiatan ini, mitra diharapkan dapat mengetahui cara perhitungan harga pokok produksi dan penentuan harga jual dan mengetahui pentingnya penentuan tersebut melalui perhitungan yang sesuai standar.