bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of meditation music and comedy movie interventions on postoperative kinesiophobia and pain in patients undergoing total knee arthroplasty
Authors: Cici Remziye , Bulbuloglu Semra , Kapikiran Gurkan 
Published: December 2022

AbstractBackgroundThis study aimed to investigate the effects of music and comedy movie interventions on postoperative pain and kinesiophobia in patients who underwent total knee arthroplasty.MethodsThis randomized‐controlled study was carried out with the participation of patients who underwent total knee arthroplasty. The patients were divided into three groups. To reduce surgical pain and kinesiophobia, the patients in group 1 watched a comedy movie, those in group 2 listened to music, and those in group 3 did not participate in any intervention other than the routine practices of the clinic.ResultsThe personal and medical characteristics of the patients in all groups were similar. The patients in all three groups were kinesiophobic, and their surgical pain levels were moderate despite pharmaceutical interventions. Groups 1 and 2 had a statistically significant decrease in kinesiophobia and pain scores after the interventions. The effects of having patients watch a comedy movie and having them listen to meditation music were not significantly different.ConclusionsThe results of the study showed that listening to meditation music or watching comedy movie scenes had significant positive effects in alleviating postoperative pain and kinesiophobia after TKA. Based on the results of this study, it is recommended that patients watch comedy movies and listen to meditation music to alleviate their postoperative pain and kinesiophobia.Trial RegistrationNCT, NCT05471778. The study was registered at ClinicalTrials.gov.
Course of subthreshold manic symptoms and related risk factors in the general population: A three‐year follow‐up study
Authors: Beekman Rosalie A. L. , ten Have Margreet , de Graaf Ron , Kupka Ralph W. , Regeer Eline J. 
Published: December 2022

AbstractObjectivesSubthreshold manic symptoms (subM) are a risk factor for the onset and recurrence of bipolar disorder (BD). Individuals with subM may benefit from preventive interventions, however, their development is hampered by a lack of knowledge on subM prevalence and subsequent course. This study examines subM characteristics, course, and risk factors for an unfavourable course.MethodsIn a Dutch representative, population‐based sample aged 18–64 (N = 4618), we assessed subM, defined as the occurrence of manic core symptoms (elation/irritability), without meeting full DSM‐IV criteria for BD I or II in the past 3 years. Comparison groups had either no manic symptoms (noM) or hypomania/mania in the context of BD (mBD) in the past 3 years. Furthermore, we differentiated a mild and moderate type of subM, based on the number of manic symptoms. A subsequent three‐year course was assessed prospectively.ResultsSubM had a three‐year prevalence of 4.9%. Its prevalence, characteristics, and course were in between noM and mBD, and there were few differences between mild and moderate subM. Over the 3‐year follow‐up, 25.0% of individuals with subM had persistent subM and another 6.1% transitioned to mBD. Eleven significant risk factors for this unfavourable course were found. The most important were a history of depression/dysthymia (OR 3.75, p ≤ 0.001), living alone (OR 2.61, p ≤ 0.01) and elevated neuroticism score (OR 1.21, p ≤ 0.001).ConclusionsThis study supports the validity and clinical relevance of subM as a BD prodrome. It demonstrates that subM symptoms often persist or increase during follow‐up and identifies 11 risk factors that are associated with an unfavourable course.
Scaling‐up an early childhood parenting intervention by integrating into government health care services in rural Bangladesh: A cluster‐randomised controlled trial
Authors: Mehrin Syeda Fardina , Salveen Nur‐E , Kawsir Masuma , Grantham‐McGregor Sally , Hamadani Jena D. , Baker‐Henningham Helen 
Published: December 2022

AbstractAimsWe evaluated the feasibility and effectiveness of utilising government health supervisors to train and supervise primary health care workers (HWs) in community clinics to deliver parenting sessions as part of their usual duties.MethodsWe randomly allocated 16 unions in the Mymensing district of Bangladesh 1:1 to an intervention or control group. HWs in clinics in the eight intervention unions (n = 59 health workers, n = 24 clinics) were trained to deliver a group‐based parenting intervention, with training and supervision provided by government supervisors. In each of the 24 intervention clinics, we recruited 24 mothers of children aged 6–24 months to participate in the parenting sessions (n = 576 mother/child dyads). Mother/child dyads attended fortnightly parenting sessions at the clinic in groups of four to five participants for 6 months (13 sessions). We collected data on supervisor and HW compliance in implementing the intervention, mothers' attendance and the observed quality of parenting sessions in all intervention clinics and HW burnout at endline in all clinics. We randomly selected 32 clinics (16 intervention, 16 control) and 384 mothers (192 intervention, 192 control) to participate in the evaluation on mother‐reported home stimulation, measured at baseline and endline.ResultsSupervisors and HWs attended all training, 46/59 health workers (78%) conducted the majority of parenting sessions, (only two HWs [3.4%] refused) and mothers' attendance rate was 86%. However, supervision levels were low: only 32/57 (56.1%) of HWs received at least one supervisory visit. Intervention HWs delivered the parenting sessions with acceptable levels of quality on most items. The intervention significantly benefitted home stimulation (effect size = 0.53SD, 95% confidence interval: 0.50, 0.56, p < 0.001). HW burnout was low in both groups.ConclusionIntegration into the primary health care service is a promising approach for scaling early childhood development programmes in Bangladesh, although further research is required to identify feasible methods for facilitator supervision.
The relationship between family empowerment and fine motor, gross motor and cognitive skills in young children with cerebral palsy
Authors: Pierce Samuel R. , Skorup Julie , Paremski Athylia C. , Prosser Laura A. 
Published: December 2022

AbstractBackgroundFamily empowerment in families of young children with cerebral palsy (CP) is an important consideration because the first few years of life can be overwhelming for parents. The purpose of this research was to investigate the relationship between family empowerment, fine motor (FM), gross motor (GM) and cognitive development in children with CP who were under 3 years of age.MethodsForty‐one children with a mean age of 23.8 months participated in this study. The Family Empowerment Scale (FES) was completed by the participants' parents, whereas the FM, GM and cognitive subscales of the Bayley Scales of Infant and Toddler Development Third edition (B‐III) were administered by physical therapists.ResultsStatistically significant positive correlations were found between the FES total and B‐III raw scores for FM, GM and cognitive subscales with coefficients ranging from 0.35 to 0.41. Significant relationships were also found between the FES Community subscale and the B‐III FM, GM and cognitive subscales.ConclusionsThis study provides evidence of a relationship between family empowerment and FM, GM and cognitive abilities in young children with CP, with a greater severity of impairments related to lower levels of caregiver empowerment.
Language‐specific phonological skills and the relationship with reading accuracy in Sylheti‐English sequential bilinguals
Authors: McCarthy Kathleen M. , Skoruppa Katrin 
Published: December 2022

AbstractThis study investigated the influence of first language (L1) phonology on second language (L2) early reading skills in Sylheti‐English bilinguals (N = 58; 48% girls; British Bangladeshi) and their monolingual‐English peers (N = 43; 45% girls; 96% White British, 4% multiethnic British) in a diaspora context. Language‐specific phonological awareness and nonword repetition were tested at two time points (6;2–7;8 years‐old). At Time 1, the bilinguals had lower productive accuracy for phonological sequences that violated their L1 phonology (d = .56; .84), and these skills accounted for a significant amount of variance in their reading accuracy. At Time 2, the language‐specific effects were no longer present. These findings highlight the importance of considering language structure in multilingual early literacy development.
Comprehensive analysis of immune cell infiltration and role of MSR1 expression in aneurysmal subarachnoid haemorrhage
Authors: Wang Xing , Wen Dingke , You Chao , Tao Chuanyuan , Ma Lu 
Published: December 2022

AbstractAneurysmal subarachnoid haemorrhage (aSAH), resulting from the rupture of intracranial aneurysms, can yield high mortality and disability. This study aimed to explore the immune infiltration of aneurysmal tissues and investigate a novel mechanism underlying aSAH. We downloaded datasets containing expression profiles of aneurysmal and normal arterial tissues from the online database. Then a comprehensive bioinformatic strategy was conducted to select the biomarkers of aneurysmal tissues. Two calculation algorithms were performed to identify the unique immune characteristics between aneurysmal tissues and normal arteries. Double immunofluorescence staining was used to investigate the role of pathway‐related proteins in the inflammatory process after aSAH. Six microarray datasets were integrated, and another RNA‐sequencing dataset was used as the validation dataset. Functional enrichment analysis of the differentially expressed genes indicated that immune‐related processes were closely related to the progression of aSAH. We then performed immune microenvironment infiltration analysis, and the results suggested macrophages were abnormally enriched in aneurysmal tissues. Core gene MSR1 was filtered through a comprehensive bioinformatic strategy. Our analysis suggested that MSR1 might be associated with macrophage activation and migration. Our study elucidated the impact of macrophage and MSR1 on aSAH progression. These findings were helpful in gaining insight into the immune heterogeneity of aneurysmal tissues and normal arteries, and in identifying patients who might benefit from immunotherapy.
Identifying the current and future status of freshwater connectivity corridors in the Amazon Basin
Authors: Caldas Bernardo , Thieme Michele L. , Shahbol Natalie , Coelho Maria E. , Grill Guenther , Van Damme Paul A. , Aranha Ricardo , Cañas Carlos , Fagundes Camila K. , Franco‐León Nicole , Herrera‐Collazos Edgar E. , Jézéquel Céline , Montoya Mariana , Mosquera‐Guerra Frederico , Oliveira‐da‐Costa Marcelo , Paschoalini Mariana , Petry Paulo , Oberdorff Thierry , Trujillo Fernando , Tedesco Pablo A. , de Brito Ribeiro Mauro César Lambert 
Published: December 2022

AbstractThe Amazon Basin features a vast network of healthy, free‐flowing rivers, which provides habitat for the most biodiverse freshwater fauna of any basin globally. However, existing and future infrastructure developments, including dams, threaten its integrity by diminishing river connectivity, altering flows, or changing sediment regimes, which can impact freshwater species. In this study, we assess critical rivers that need to be maintained as freshwater connectivity corridors (FCCs) for selective freshwater species—long‐distance migratory fishes and turtles (both with migrations >500 km) and river dolphins. We define FCCs as river stretches of uninterrupted river connectivity that provide important riverine and floodplain habitat for long‐distance migratory and other species and that maintain associated ecosystem functions. We assessed more than 340,000 km of river, beginning with an assessment of the connectivity status of all rivers and then combining river status with models of occurrence of key species to map where FCCs occur and how they could be affected under a scenario of proposed dams. We identified that in 2019, 16 of 26 very long (>1000 km) rivers are free‐flowing but only 9 would remain free‐flowing if all proposed dams are built. Among long and very long rivers (>500 km), 93 are considered FCCs. Under the future scenario, one‐fifth (18) of these long and very long FCCs—those that are of critical importance for long‐distance migrants and dolphins—would lose their FCC status, including the Amazon, the Negro, Marañón, Napo, Ucayali, Preto do Igapó Açu, Beni, and Uraricoera rivers. To avoid impacts of poorly sited infrastructure, we advocate for energy and water resources planning at the basin scale that evaluates alternative development options and limits development that will impact on FCCs. The results also highlight where corridors could be designated as protected from future fragmentation.
A phase 2a, randomized, double‐blind, placebo‐controlled, three‐arm, parallel‐group study to assess the efficacy, safety, tolerability and pharmacodynamics of PF‐06835919 in patients with non‐alcoholic fatty liver disease and type 2 diabetes
Authors: Saxena Aditi R. , Lyle Stephanie‐An , Khavandi Kaivan , Qiu Ruolun , Whitlock Mark , Esler William P. , Kim Albert M. 
Published: December 2022

AbstractAimTo assess the safety, tolerability and pharmacodynamics (PD) of the ketohexokinase inhibitor PF‐06835919 in participants with non‐alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D).Materials and methodsThis double‐blind, placebo‐controlled, parallel‐group study enrolled adults with NAFLD (≥ 8% whole liver fat [WLF] using MRI proton density fat fraction [MRI‐PDFF]) and T2D on stable doses of metformin (≥ 500 mg/day). Participants received once‐daily placebo, PF‐06835919 150 or 300 mg for 16 weeks. Randomization (1:1:1) was via an interactive response technology system. Endpoints included percentage change from baseline (CFB) in WLF using MRI‐PDFF (primary endpoint) and CFB in HbA1c (co‐primary endpoint) at 16 weeks, PD, safety and tolerability.ResultsAmong 164 participants randomized and treated, 145 completed the treatment (placebo, n = 50; PF‐06835919 150 mg, n = 46; PF‐06835919 300 mg, n = 49). At week 16, least squares mean (90% confidence interval) percentage CFB in WLF was −5.26% (−12.86%, 2.99%), −17.05% (−24.01%, −9.46%) and −19.13% (−25.51%, −12.20%) in the placebo, PF‐06835919 150‐mg and 300‐mg groups, respectively (PF‐06835919 300‐mg group vs. placebo, P = .0288). Modest numerical reductions in HbA1c were observed in all groups that did not reach statistical significance. Treatment‐emergent adverse event incidence was similar across groups (40.7%, 45.5% and 32.7% in the placebo, PF‐06835919 150‐mg and 300‐mg groups, respectively), with no apparent dose‐related trend.ConclusionsPF‐06835919 administration over 16 weeks was generally safe and well tolerated and resulted in reductions in WLF in participants with NAFLD and T2D.
Abernethy malformation with unusual cardiac malformation: Case report and literature review
Authors: Xu Liyuan , Zhang Hongju , Liu Guowen , Li Yunpeng , Li Di , Ma Ning 
Published: December 2022

AbstractAbernethy malformation, also known as congenital extrahepatic shunt, is a rare anomaly, which is characterized by partial or complete diversion of the portal blood into the systemic venous circulation. The clinical manifestations of Abernethy malformation during childhood include neonatal cholestasis, failure to thrive, mental retardation, and other congenital defects. We report a case of Abernethy malformation Type II in a 9‐year‐old boy, whose left ventricle was slightly enlarged because of several major aortopulmonary collateral arteries (MAPCAs) but laboratory examinations were normal 5 years earlier. The characteristics of congenital heart disease in patients with Abernethy malformation are discussed. We propose that physicians should be aware of the possibility of Abernethy malformation in children with enlargement of the left ventricular due to systemic‐pulmonary collateral circulation.
Epilepsy in cerebral amyloid angiopathy: an observational retrospective study of a large population
Authors: Tabaee Damavandi Payam , Storti Benedetta , Fabin Natalia , Bianchi Elisa , Ferrarese Carlo , DiFrancesco Jacopo C. 
Published: December 2022

AbstractObjectiveCerebral amyloid angiopathy (CAA) is a major cause of spontaneous intracranial hemorrhage in older adults. Epilepsy represents a possible sequela of the disease. To date, studies on epilepsy in CAA are lacking, and the few data available mainly focus on CAA‐related inflammation (CAA‐ri), the inflammatory form of the disease.MethodsIn this retrospective observational study, we consecutively recruited CAA patients observed over a time span of 10 years, collecting demographic, clinical, and instrumental data. Significant baseline characteristics were evaluated as potential risk factors for the development of epilepsy in the CAA population, and in the subgroups of CAA‐ri and CAA without inflammatory reaction (CAA‐nri). The effect of potential risk factors for epilepsy was measured as odds ratio with 95% confidence interval.ResultsWithin 96 recruited CAA cases, 33 (34.4%) developed epilepsy during follow‐up (median = 13.5 months). The prevalent type of seizure was focal (81.3%); 12.1% of the epileptic patients presented status epilepticus, and 6.1% developed drug‐resistant epilepsy. Electroencephalographic traces revealed slow and epileptic discharge activity in the majority of epileptic patients, but also in those without epilepsy. The presence of focal or disseminated cortical superficial siderosis (cSS) was associated with an increased risk of epilepsy in the CAA‐nri group, and the association with CAA‐ri and epilepsy was present in the overall population.SignificanceEpilepsy is a common manifestation during the course of CAA, where CAA‐ri and cSS represent predisposing factors for the development of seizures. These data suggest the importance of a deep characterization of CAA patients, to better select those more prone to develop epilepsy.
Persistent alteration of the skin microbiome in patients with skin rash after receiving EGFR inhibitor treatment
Authors: Ashida Atsuko , Tomida Shuta , Iwabuchi Tokuro , Sato Yuki , Kiniwa Yukiko , Okuyama Ryuhei 
Published: December 2022

AbstractThe pathological mechanism responsible for EGFR inhibitor (EGFRI)‐induced skin rash remains unclear. Recent studies reveal associations between skin dysbiosis and skin inflammatory diseases. This study aimed to examine whether skin dysbiosis is associated with EGFRI‐induced skin rash. Bacterial swabs were taken from the forehead of 17 cancer patients at baseline and at several time points after EGFRIs initiation, as well as from 20 healthy controls. The skin microbiome was analysed using 16S rRNA sequencing. The severity of the skin rash was assessed using the rash grade. Skin surface parameters (pH, water capacitance, and sebum level) were also measured. Compared with baseline, the abundance of Cutibacterium acnes decreased in 13 of 15 cases, and that of Staphylococcus aureus, Corynebacterium spp., Staphylococcus epidermidis or Proteobacteria increased in 13 of 15 cases after EGFRIs initiation. Skin pH increased significantly in parallel with a decrease in water capacitance after EGFRI initiation. Also, the composition of the skin microbiome of patients with severe rash was significantly different from that of healthy controls. In addition, the skin dysbiosis did not return to baseline during EGFRIs treatment for >1 year. These longitudinal observations indicate that skin dysbiosis is associated with development of skin rash.
Reviving the unique potential of recreational fishers as environmental stewards of aquatic ecosystems
Authors: Shephard Samuel , List Charles J. , Arlinghaus Robert 
Published: December 2022

AbstractRecreational anglers have been key players in aquatic conservation, but this role is increasingly obscured. Other environmental sectors are now more visible stakeholders engaged with biodiversity. Recreational fishing has relevant environmental and moral implications, but these can be resolved via improved governance and management. More difficult is replacing the stewardship capacity provided by anglers. When analysed against a novel environmental stewardship framework based on place and identity, care, knowledge and agency, we find that marginalizing anglers could diminish aquatic biodiversity conservation. This outcome is likely because excellence in recreational fishing involves habituation of skills and ethical imperatives associated with sustainable and responsible use of fish populations. These dimensions are probably not so pertinent and correspondingly less developed in other nature stakeholders. Importantly, catching and killing wild animals catapults anglers into a food web and associated ecological conscience that most other outdoor activities cannot generate. As a result, recreational fishing often engenders feelings of care and responsibility for aquatic systems that support personal well‐being, bridging the stewardship value‐action gap through development of local assessment, management and evaluative competencies and associated agency. Transdisciplinary cooperation with scientists, managers and policymakers can unleash the stewardship potential of recreational anglers and engage their capacity for the common good.
Narrativas segmentadoras e igualitarias en la práctica normativa de la OIT
Authors: HAHS Jenny , MÜCKENBERGER Ulrich 
Published: December 2022

ResumenAl configurar la relación de trabajo a nivel internacional, la OIT reprodujo inicialmente la narrativa normativa occidental de la relación de trabajo típica. Cuando el Sur global y las mujeres ganaron voz, una narrativa igualitaria alternativa se opuso a la hegemonía de la relación de trabajo típica y generó una estratificación de narrativas. Desde el institucionalismo histórico y la teoría de la estructuración, los autores observan la trayectoria de estas narrativas y tratan de explicarlas por la evolución de la composición de la OIT y de la representación femenina en la Conferencia Internacional del Trabajo. De ello extraen una serie de conclusiones jurídico‐políticas.