bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of nutritional counseling for Head and Neck Cancer patients undergoing radiochemotherapy: a pilot prospective study
Authors: Becherini Carlotta , Desideri Isacco , Cherici Sofia , Pancani Serena , Alpigiano Giovanna , Salvestrini Viola , Valzano Marianna , Scoccimarro Erika , Orsatti Carolina , Peruzzi Anna , Livi Lorenzo , Bonomo Pierluigi 
Published: September 2022

Abstract
PurposeExpected weight loss and discontinuation of the planned therapeutic program plays a key role in oncological care and treatment effectiveness in Head-Neck Cancer (HNC) patients.We aimed to determine the impact of dietary counselling in a prospective cohort of patients with HNC undergoing radio-chemotherapy. MethodsThis single-centre prospective study was conducted, between November 2020 and March 2021, on 17 consecutive patients treated with radio-chemotherapy or radiotherapy for HNC. At baseline, nutrition risk assessment was performed using the Malnutrition Universal Screening Tool (MUST). Nutritional outcome and morbidity, during and 1 month after the end of treatment, were evaluated. ResultsThe most commonly observed issues at baseline were inadequate oral intake and involuntary weight loss, with inadequate energy intake as the most frequent cause (38%). At mid-treatment (T1), mean body weight showed a reduction from baseline, with a slight increase at the end of therapy. Overall, we observed body weight stability during the treatment period and a recovery from the observed minimum weight (mean 74.3 vs 74.4 kg, min 59 vs 57.3 kg). ConclusionOur data suggest that nutritional counseling should be adopted to increase dietary intake and to prevent therapy-associated weight loss and treatment adherence reduction.
RNA Demethylase ALKBH5 Promotes Progression and Angiogenesis of Lung Cancer via Regulating the Stability of LncRNA PVT1
Authors: Shen Wenyi , Pu Juan , Zuo Zhi , Gu Shanye , Sun Jing , Tan Bing , Wang Lili , Cheng Jianmeng , Zuo Yangsong 
Published: September 2022

Abstract
Background
N6-methyladenosine (m6A) is the most common posttranscriptional modification of RNA and plays critical roles in human cancer progression. However, biological function of the m6A methylation needs to be further studied in cancer, especially on tumor angiogenesis.
Methods
The public database were used to analyze the expression and overall survival of ALKBH5 and PVT1 in lung cancer patients. CCK-8 and colony formation assays were performed to detect the cell proliferation, transwell assay was used to assess the cell migration, and tube formation assay was performed to assess the angiogenic potential in vitro. The zebrafish lung cancer xenograft model was used to verify the function of ALKBH5 and PVT1 in vivo. Western-blot assay was used to measure the expression of relative protein in lung cancer cells. SRAMP predictor analysis and RNA stability experiments were used to examine the potential m6A modification.
Results
Bioinformatics analysis showed the expression levels of m6A-related genes were changed significantly in lung cancer tissues comparing with normal lung tissues. We then identified that ALKBH5 was upregulated in lung cancer tissues and associated with poor prognosis of lung cancer patients by analyzing the public database. Knockdown of ALKBH5 inhibited the proliferation and migration of cultured lung cancer cell lines. Zebrafish lung cancer xenografts also showed ALKBH5 silence suppressed the growth and metastasis of lung cancer cells. Moreover, knockdown of ALKBH5 inhibited the angiogenesis of lung cancer in vitro and in vivo. Mechanism studies showed that knockdown of ALKBH5 decreased the expression and stability of PVT1 in lung cancer cells. We next verified that PVT1 promoted the progression of lung cancer cells in vitro and in vivo, and it also regulated the expression of VEGFA and angiogenesis of lung cancer. Finally, rescue experiments revealed that ALKBH5 regulated the proliferation, migration and angiogenesis of lung cancer cells partially through PVT1.
Conclusion
Our results demonstrate ALKBH5 promotes the progression and angiogenesis of lung cancer via regulating the expression and stability of PVT1, which provides the potential prognostic and therapeutic target for lung cancer patients.
Nutrient deficient forage for critically endangered Cervus hanglu hanglu: A serious concern for conservationists
Authors: Buch Khuban , Mugloo J. A. , Ahmad Khursheed , Sheikh G.G. , Raj Anup , Khan P.A. , Mir Ashfaq A. , Pala Nazir A. , Saleem Ishrat , Arjumand Tahera , Mehraj Basira 
Published: September 2022

AbstractThe present study reports the distribution of preferred forage and its nutritional composition with respect to four different habitats (Riverine, Grassland/Scrub, Mixed-Woodland, Pine-Parrotiopsis) of critically endangeredCervus hanglu hanglu(Hangul) in Dachigam National Park, Jammu and Kashmir of Indian Himalaya for autumn season. This preferred forage is documented and analyzed to establish a data base on the nutritional status of hangul for better understanding of management measures, ensuring effective conservation. The study area was sampled with stratified random sampling design by laying down three (03) transects each in Four (04) selected habitats. The results reveal that 25 preferred plant species are available across four different habitats dominated by riverine (16), grassland/scrub (10), mixed-woodland (9) and eight (8) in pine-parrotiopsis. Hangul rely on variety of forage species for important nutrients that support their physiological functions and nutritional requirements. The assessment of nutrient quality of habitats indicates that with regard to protein content which is influential for growth of deer, especially for fawns and yearlings, maximum of it is found inHedera nepalensis(17.30%) from pine-parrotiopsis habitat. The study concludes that the different habitats in Dachigam National park can sustain more of the adult deer individuals which require 6 to 8 percent for their maintenance but young and growing deer may face deficit of it which is of great concern for the fawn survival in Hangul population. Our study indicates that enhancing these habitats by vegetatively propagating highly nutritious species that would satisfy the nutritional requirements of deer throughout the year may have an important role in managing a healthy deer population.
Selecting a Voting Method: The Case for the Borda Count
Authors: Saari Donald G. 
Published: September 2022

Abstract
Of importance when selecting a voting method is whether, on a regular basis, its outcomes accurately capture the intent of voters. A surprise is that very few procedures do this. Another desired feature is for a decision approach to assist groups in reaching a consensus (Sect. 5). As described, these goals are satisfied only with the Borda Count (BC).
Addressing these objectives requires understanding what can go wrong, what causes voting difficulties, and how bad they can be. To avoid technicalities, all of this is illustrated with examples accompanied by references for readers wishing a complete analysis. As shown (Sects. 1–3), most problems reflect a loss of vital information. Understanding this feature assists in showing that the typical description of Arrow’s Theorem, “with three or more alternatives, no voting method is fair,” is not accurate (Sect. 2).
JEL Classification D71 D72
Cross-talks Between Gut Microbiota and Tobacco Smoking: A Two-Sample Mendelian Randomization Study
Authors: Zhou Dan , Fan Jiayao , Zhou Yuan , Meng Ran , Tang Jinsong , Zhu Jiahao , Aldrich Melinda , Cox Nancy , Zhu Yimin , Li Yingjun 
Published: September 2022

AbstractConsiderable evidence has been reported that tobacco use could cause alterations in gut microbiota composition. The microbiota-gut-brain axis also in turn hinted at a possible contribution of gut microbiota to smoking. However, population-level studies with a higher evidence level for causality are lacking. This study deployed two-sample bidirectional Mendelian randomization (MR) design to reveal the causal association between gut microbiota and tobacco smoking. The summary-level data of genome-wide association studies (GWAS) for 211 gut microbial taxa and five smoking phenotypes were acquired from meta-analyzed datasets with totally 1.7 million European ancestry-dominated samples. Our MR results confirmed the effects of smoking on three taxa (Intestinimonas,Catenibacterium, andRuminococcaceae, observed from previous studies) with boosted evidence level and identified another thirteen taxa which may be causally affected by tobacco smoking. As for the other direction, we revealed that smoking behaviors could be potential consequence of taxa abundance. Combining with existing observational evidence, we provided novel insights regarding a positive feedback loop of smoking addiction throughActinobacteriaand indicated a potential mechanism for the link between parental smoking and early smoking initiation of their children driven byBifidobacterium. In summary, the current study suggested a substantial role of the intestinal microbes on the risk for cigarette smoking, and in turn smoking on intestinal microbes. Our findings highlighted the hazards of tobacco use for gut flora dysbiosis and shed light on the potential role of gut microbiota for tobacco control.
Impact of building energy mitigation measures on future climate
Authors: Pokhrel Rabindra , Comarazamy Daniel , Ramamurthy Prathap , Gonzalez Jorge E. 
Published: September 2022

Abstract
As Cities are increasing technological efficacy on greenhouse gas (GH) emissions reduction efforts, the surrounding urban ecosystems and natural resources maybe affected by these measures. In this research, climate indicators such as heat index, extreme hot events, intensified urban heat island (UHI) and sea-breeze are projected for mid and end of 21st century to understand the climate change signal on these variables with and without building energy mitigation measures. Cities amplify extreme heat and UHI impacts by concentrating large populations and critical infrastructure in relatively small areas. Here, we evaluate the combined climate and building energy mitigation impacts on localized climate metrics throughout the 21st century across extreme emissions scenarios (RCP8.5) for the tropical coastal city of San Juan. Analysis of statistically downscaled global circulation models outputs shows underestimation for uncorrected summer daily maximum temperatures, leading to lower extreme heat intensity and duration projections from present time which are corrected using bias corrected techniques. High resolution dynamical downscaling simulations reveal strong dependency of changes in extreme heat events at urban settings, however the intensities shift to lower level grassland and cropland with energy mitigation measures (combination of white roof, tilted photovoltaic and efficient heating ventilation and air conditioning system). The building energy mitigation measures have the potential of reducing the UHI intensities to 10C and 0.50C for 2050 and 2100 climate period, respectively.
Characteristics and outcomes of cancer patients with pre-existing microscopic colitis after exposure to immune checkpoint inhibitors
Authors: Thomas Austin R , Liu Cynthia , Tong Yi T , Tan Dongfeng , Altan Mehmet , Siddiqui Bilal A , Khan Anam , Thomas Anusha S , Wang Yinghong 
Published: September 2022

Abstract
Purpose
Immune checkpoint inhibitors (ICIs) are frequently associated with adverse events, often affecting the gastrointestinal tract. We conducted this study to determine the characteristics and outcomes of cancer patients with pre-existing microscopic colitis (MC) who underwent ICI treatment.
Methods
In this retrospective study, we identified 10 patients with pre-existing MC who received ICIs at our center 01/2010-06/2020. Clinical characteristics and disease outcomes were recorded.
Results
Of 124 screened patients with MC before ICI exposure, 10 had sufficient data to be included in the study. Melanoma (40%) and lung cancer (30%) were the most prevalent cancer types, with 70% of stage IV cancer. Most patients (90%) received anti–programmed death ligand 1 monotherapy. Six patients (60%) had collagenous colitis, and 4 (40%) had lymphocytic colitis. The median time from MC diagnosis to ICI initiation was 4 years, with 1 patient on budesonide within 2 months of ICI initiation. Eight patients (80%) developed colitis exacerbations after ICI requiring selective immunosuppression. One patient received a compassionate-use fecal transplantation. The median time from ICI to colitis exacerbation was 14 days, with 40% and 50% of patients experiencing grade 3 diarrhea and grade 2 colitis, respectively leading to hospitalization in 3 patients. Six patients received steroids and vedolizumab with no colitis recurrence. Of 8 patients who had colitis exacerbation, 6 resumed ICI therapy afterwards; with 5 receiving concomitant vedolizumab for secondary prophylaxis.
Conclusion
Our findings suggest that ICI exposure increases the risk of exacerbation of underlying colitis necessitating and responding to potent immunosuppression therapy.
Discrepancies of cardio-muscular biomarkers in the diagnosis and prognostication of immune checkpoint inhibitor (ICI)-associated myocarditis
Authors: Lehmann Lorenz H. , Heckmann Markus B. , Bailly Guillaume , Finke Daniel , Stein Frederic , Power John R , Bretagne Marie , Ederhy Stephane , Fenioux Charlotte , Procureur Adrien , Hamwy Omar , Pinna Bruno , Romano Emanuela , Allenbach Yves , Palaskas Nicolas L. , Katus Hugo A. , Similowski Thomas , Giannitsis Evangelos , Frey Norbert , Kaya Ziya , Moslehi Javid , Salem Joe-Elie 
Published: September 2022

Abstract
Background: Immune-checkpoint inhibitors (ICI) are approved for multiple cancers but can result in ICI-associated myocarditis, an infrequent but life-threatening condition. Elevations in cardiac biomarkers, troponin-I (cTnI), troponin-T (cTnT) and creatine-kinase (CK) are used for diagnosis. However, the temporal elevation of these biomarker elevations with course of disease and their association with outcomes have not been established.
Methods: We analyzed the diagnostic accuracy and prognostic performances of cTnI, cTnT and CK in ICI-myocarditis (n=61) in two cardio-oncology units (APHP.Sorbonne, France & Heidelberg, Germany). Major adverse cardio-myotoxic events (MACE) were defined as heart failure, ventricular arrhythmia, atrioventricular/sinus block requiring pacemaker, respiratory muscle failure requiring mechanical ventilation, and related death. Diagnostic performances of troponins were also assessed in an international ICI-myocarditis registry (n=244 independent cases, 13 countries).
Results: On presentation, cTnT, cTnI or CK were increased compared to upper reference limit (URL) in 51/52 (98%), 28/34 (82%, p=0.009 vs. cTnT), 33/48 (69%, p<0.0001 vs. cTnT), respectively. This higher rate of positivity for cTnT vs. cTnI was independently confirmed in an international registry. In patients surviving to 30 days, cTnI and CK had normalized in 20/34(59%) and 30/35(86%), respectively, while cTnT had reached normal values in only 5/42(12%), (p<0.0001). The highest value of cTnT/URL within the first 72h of admission performed best in predicting MACE (AUC:0.82) vs. CK/URL (AUC:0.74) and cTnI/URL (AUC:0.67), even after adjustment for age and sex. Maximal value of cTnT/URL≥32 within ≤72h of diagnosis was the best predictor cut-off for MACE (Hazard-ratio=9.4(95% CI 3.1, 28.3), p<0.0001) over a median follow-up of 4 months. cTnT was increased in all patients just before MACE (22/22, 100%) while cTnI and CK values were normal in 3/21(14%) and 6/24(25%) of patients (p<0.0001).
Conclusions. Significant discrepancies between cTnT (compared to cTnI, and CK) circulating levels exist in ICI-myocarditis. cTnT is the best predictor of MACE and most suitable for diagnosis and surveillance. A ratio of cTnT/URL<32 within ≤72h of diagnosis identifies a subgroup at low-risk of MACE.
Damage identification of bridge structures based on extended Kalman filter algorithm without prior knowledge of road roughness and moving vehicle
Authors: Ding Hong-li , Zhang Chun , Gao Yu-wei , Huang Jin-peng 
Published: September 2022

AbstractIdentifying contact moving load and bridge damage based on the bridge vibration signals is a classic inverse problem. Meanwhile, the ill-poseness of the inverse problem is serious and the results may not converge due to the unknown vehicle parameters and road roughness. In this study, the transformation strategy of VBI model is used to eliminate the effects of unknown vehicle parameters and excitation, and then a new method is proposed to identify bridge structural damages and moving vehicle-bridge contact force step by step. In the each recursive step, the extended Kalman filter (EKF) method with \(l1\)-norm regularization are used to obtain the minimum variance estimation of moving contact force or bridge damages from a limited numbers of response measurements. Numerical analyses of a simply-supported bridge under the moving vehicle are conducted to investigate the accuracy and efficiency of the proposed method. Effects of the vehicle speed, the damage cases, the measurement noise, and the roughness levels on the accuracy of the identification results are investigated. The results demonstrate the robustness and efficiency of the proposed algorithm which can be developed into an effective tool for structural health monitoring of bridges.
Three-decade research development of ibogaine use for the treatment of substance-related disorders: a bibliometric analysis
Authors: Fernandes-Nascimento Maria Helha , Negrão André Brooking , Ferreira-Viana karine , Chaves Bruno Rasmussen , Yuan-Pang Wang 
Published: September 2022

Abstract
Objective

To evaluate the publications on ibogaine use for substance-related disorders treatment over the last three decades.

Method

Bibliometric analysis of publications on ibogaine for the treatment of substance-related disorders from 1991 to 2020 using VOSviewer software. We performed a Scopus database search using the terms: ibogaine, 12-methoxybogamine, endabuse, tabernanthe iboga, NIH-10567, and noribogaine. Publications related to ibogaine was compared between the three decades using the Tukey test at 95% confidence level, and the behavior period evaluated considered linear and polynomial regression models.

Results

Regression models indicated that publications dedicated to ibogaine for treating substance use disorders grew by 5.1 publications per year between 1991–2000 (R2 = 0.993). The period from 2001 to 2020 showed a different expansion compared to the previous period, with fluctuations within a constant flow of publications and an increase in the volume of publications was observed until the middle of this decade (R2 = 0.889). The same tendency was seen in the last decade, 2011–2020 (R2 = 0.949). The US is the most prominent country.

Conclusion

The present study indicates that, despite differences and fluctuations among the decades analyzed, publications continue year by year and propose future directions for new interventions in the public health.
Adding a spur valve to laparoscopic portoenterostomy for patients with biliary atresia can achieve a high jaundice clearance rate and lower the number of episodes of cholangitis
Authors: Yasui Akihiro , Hinoki Akinari , Amano Hizuru , Shirota Chiyoe , Tainaka Takahisa , Sumida Wataru , Yokota Kazuki , Makita Satoshi , Okamoto Masamune , Takimoto Aitaro , Nakagawa Yoichi , Uchida Hiroo 
Published: September 2022

Abstract
Purpose: This study aimed to evaluate the efficacy of adding a spur valve to laparoscopic portoenterostomy for patients with biliary atresia.
Methods: We retrospectively reviewed the records of all patients diagnosed with biliary atresia (BA) who underwent laparoscopic portoenterostomy (Lap-PE) between 2013 and 2021. The patients were divided into two groups: Lap-PE with a spur valve (spur group) and without it (control group). Perioperative management was the same in both groups. We compared patient backgrounds and clinical outcomes, including jaundice clearance and the number of postoperative cholangitis episodes.
Results: Of 63 patients reviewed, 16 received a spur valve. There were no statistically significant differences in the patient backgrounds between the groups. All patients in the spur group achieved jaundice clearance. The number of postoperative cholangitis episodes one year after surgery was significantly lower in the spur group than in the control group (1 [0–3] vs. 3 [0–9], p = 0.04). The jaundice-free survival rate with the native liver at one year after surgery was significantly higher in the spur group (100% vs. 53%, p= 0.01).
Conclusions: Adding a spur valve during Lap-PE significantly lowered the number of cholangitis episodes one year after surgery.
Effects of changes in skeletal muscle mass on the prognosis of pediatric malignant solid tumors
Authors: Omori Atsuko , Kawakubo Naonori , Takemoto Junkichi , Souzaki Ryota , Obata Satoshi , Nagata Kouji , Matsuura Toshiharu , Tajiri Tatsuro , Taguchi Tomoaki 
Published: September 2022

Abstract
Purpose This study aims to clarify the relationship between changes in skeletal muscle mass during treatment and prognosis of pediatric malignant solid tumors. Methods Patients with pediatric malignant solid tumors who were treated at Kyushu University Hospital from 2007 to 2017 were divided into two groups: the progression-free survival (PFS) group and the relapse/death (R/D) group; the psoas major muscle volume (PMV) was then compared. We also measured the PMV and psoas muscle area (PMA) of pediatric patients with no complications who underwent surgery for acute appendicitis (control) and compared the values with those of patients with malignant tumors. Results No significant differences were observed in the PMV and PMA between patients with appendicitis and those with malignant tumors. Significant differences were found in the rate of change in PMV between the PFS (1.424) and R/D groups (1.071) ( P = 0.0024). When the cutoff value of the rate of change in the PMV was 1.20, patients whose rate of change in PMV was ≥ 1.20 had longer PFS ( P = 0.0231) and overall survival ( P = 0.0229) than those whose rate of change was < 1.20. Conclusion Pediatric patients with malignant solid tumors and increased skeletal muscle mass during treatment have a good prognosis.
Assessment of fish diversity in the coastal waters off Nodaedo Island, Tongyeong, Korea using underwater visual census and environmental DNA metabarcoding
Authors: Lee Yong-Deuk , Lee Gang-Min , Gwak Woo-Seok 
Published: September 2022

Abstract
Environmental DNA (eDNA) analysis is a promising method to monitor marine biodiversity. Examining the capacity of eDNA to provide accurate biodiversity measures in species-rich ecosystems such as coastal waters is a prerequisite for their application in long-term monitoring. Therefore, both underwater visual census (UVC) and eDNA metabarcoding were conducted monthly from June 2018 to May 2019 to investigate fish diversity on the coast of Nodaedo Island in Tongyeong, South Korea. A total of 16,036 individuals were observed by UVC and classified into 69 species, with perciform fish being the most dominant (31 species). eDNA metabarcoding detected 68 operational taxonomy units (OTUs) and 738,217 reads, accounting for a total of 18 orders, 42 families, and 68 species. The Gobiidae family was the most dominant taxon, encompassing five species. The UVC method could detect species that were otherwise not identified through eDNA due to the small number of individuals or analytical limitations. eDNA metabarcoding was suitable for detecting smaller species, pelagic species, and those that inhabit microhabitats. Our findings demonstrated that these two methods can complement each other to gain insights into the structure of the communities of fish that inhabit various coastal environments. eDNA metabarcoding can be applied as a fast and efficient method to conduct surveys on fish species diversity in coastal waters. However, this approach must be further compared with traditional survey methods to validate its applicability as an effective complement to traditional measures.