bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attitudes and experiences towards partnership and intimacy of the partners of BRCA women carriers: A focused group study after prophylactic surgery
Authors: Pavlišta David , Slabá Katarina , Šašková Petra , Novotný Jan 
Published: November 2022

Abstract
Currently, prophylactic surgery has been presented as the most efficacious method in reduction of breast and ovarian cancer risk in BRCA-positive women. Nevertheless, it is a life-changing surgery and can have an adverse impact on women at psychological, psychosexual, and emotional levels. The aim of our study was to determine experiences and opinions of partners of women who have undergone risk-reducing surgery for BRCA mutations and their recommendations for men who find themselves in a similar position. Focus group methodology was used. A small questionnaire was prepared. We approached 86 men whose BRCA positive female partners had undergone risk reducing surgery (mastectomy with reconstruction, PBSO) with a period of more than 12 months after the surgery. Questionnaires were prepared with six basic questions. The mean age was 43.3 years, all men had at least one child together with the woman with the gene mutation carrier. Out of 86 men, 19 men responded and only 11 participated. The results of this study show that the male partners are also affected by the prophylactic surgery in BRCA carriers. Their answers disclosed several undiscussed concerns. We may conclude that the partner of a patient with BRCA1/2 mutation is often a hidden or overt patient. We suggest that the partners may need and benefit from psycho-social support.
Asymptotic Spreading of a Cholera Epidemic Model in a Periodic Environment
Authors: Lin Guo , Pan Shuxia , Wang Xueying 
Published: November 2022

Abstract
This paper is devoted to the spreading property of a cholera epidemic model, which is built upon a time-periodic reaction-diffusion system that is not necessarily monotonic. When the initial distribution of infected hosts and bacteria appears on a compact domain, we derive a rough expansion speed of the infection over space. In the case where the model parameters are constants, we obtain some analytic properties for the speed, which allows us to understand the factors that affect the spatial spreading ability of cholera. In particular, the spreading speed of cholera is the minimal wave speed of traveling wave solutions in earlier works by taking constant parameters and special incidence functions.
AMS Subject Classification (2010): 35K57; 92D30
Postoperative intermittent pneumatic compression for preventing venous thromboembolism in Chinese lung cancer patients: A randomized clinical trial
Authors: Li Jingyao , Huang Aihong , Han Zhaojie , Zhou Yi , Tang Meng , Wu Wei , Zhang Shixin , Liao Kelong , Xie Yihui , Chen Qiao , Zou Xinliang , Liu Shuai , Gao Shuaixiang , Ren Junlong , Xu Qingyuan , Liu Xi , Liao Yi , Jing Tao , Tan WenFeng , Qiu Yang , Wang Haidong 
Published: November 2022

Abstract
Background
Postoperative lung cancer patients belong to the high-risk group for venous thromboembolism (VTE). The standardized preventive measures for perioperative VTE in lung cancer are not perfect, especially for the prevention and treatment of catheter-related thrombosis (CRT) caused by carried central venous catheters (CVCs) in lung cancer surgery.
Patients and Methods:
This study included 460 patients undergoing lung cancer surgery in the Department of Thoracic Surgery, First Affiliated Hospital, Army Medical University from July 2020 to June 2021. Patients were randomized into two groups, and intraoperatively-placed CVCs would be carried to discharge. During hospitalization, the control group was treated with low-molecular-weight heparin (LMWH) and the experimental group with LMWH + IPC. Vascular ultrasound was performed at three time points which included before surgery, before discharge, and one month after discharge. The incidence of VTE between two groups were studied by Log-binomial regression model.
Results
CRT occurred in 71.7% of the experimental group and 79.7% of the control group. The multivariate regression showed that the risk of developing CRT in the experimental group was lower than in the control group (Adjusted RR = 0.889 [95%CI 0.799–0.989], p = 0.031), with no heterogeneity in subgroups (P for Interaction > 0.05). Moreover, the fibrinogen of patients in the experimental group was lower than control group at follow-up (P = 0.019).
Conclusion
IPC reduced the incidence of CRT during hospitalization in lung cancer patients after surgery.
Clinical Trial Registration:
No. ChiCTR2000034511
Options for dynamic similarity of interacting fluids, elastic solids and rigid bodies undergoing large motions
Authors: Liu Huan , Jaykar Kalpesh , Singh Vinitendra , Kumar Ankit , Sheehan Kevin , Yip Peter , Buskohl Philip , James Richard D. 
Published: November 2022

Abstract
Motivated by a design of a vertical axis wind turbine, we present a theory of dynamical similarity for mechanical systems consisting of interacting elastic solids, rigid bodies and incompress-ible fluids. Throughout, we focus on the geometrically nonlinear case. We approach the analysis by analyzing the equations of motion: we ask that a change of variables take these equations and mutual boundary conditions to themselves, while allowing a rescaling of space and time. While the disparity between the Eulerian and Lagrangian descriptions might seem to limit the possibilities, we find numerous cases that apparently have not been identified, especially for stiff nonlinear elastic materials (defined below). The results appear to be particularly adapted to structures made with origami design methods, where the tiles are allowed to deform isometrically. We collect the results in tables and discuss some particular numerical examples.
A palaeoecological study investigating the impacts of multiple tephra depositions on a lacustrine ecosystem in Northeast China, using diatoms as environmental indicators
Authors: Deng Yuqiao Natalie , Rioual Patrick , Jones Vivienne J. , Sun Chunqing , Mingram Jens 
Published: November 2022

Abstract
Tephra layers are common in lake sediments and although they have often been used as chronological controls, few studies have investigated the impacts of past tephra depositions on lake ecosystems (Tephropalaeoecology). For the first time we systematically assess how different types of tephra layers vary in their ecological impact on the same lacustrine system. We use a diatom-based tephropalaeoecological approach to infer the impacts of five tephra deposits on Lake Sihailongwan, a well-studied volcanic lake in Northeast China, over the past 30,000 years. The five tephra layers (including two micro-tephras) have varying thicknesses and were deposited in time periods with different climatic conditions. Changes in diatom communities and chrysophyte cyst concentrations between pre- and post-tephra samples were used to infer changes in lake conditions and highlight the importance of lake background conditions in mediating the impact of tephra. While the two micro-tephra layers did not cause observable changes, the three thicker tephras induced pronounced changes in lake conditions and thus diatom communities. The two thick tephras deposited in more eutrophic and warmer lake conditions caused larger responses from diatoms. We argue that water column phosphorous decreased due to reduced sediment-water phosphorous loading as thick tephra layers formed an impermeable layer at the lake bottom. This is supported by a decrease in total diatom concentration and a decline in high phosphorous-requiring taxa such as Discostella stelligeroides and Stephanodiscus minutulus as well as modern limnological observations which showed that groundwater influxes from the lake bottom are the main source of nutrients to the lake. By contrast, the thick tephra deposited in more oligotrophic and colder lake conditions caused less conspicuous changes. When the lake was already low in phosphorous, diatoms did not respond to a further decline in phosphorous but rather responded to the minor increase in silica from the dissolution of tephra particles in the water column. This was inferred from the slight increases in overall diatom concentration and opportunistic taxa such as Cyclotella comensis fo. minima. Diatom analysis of the post-tephra sediments above the three thick tephras showed that the aquatic ecosystem did not completely recover, indicating the long-lasting effects of these thick tephras and shifts to new lake ecosystem equilibria.
Implementation of a telephone triage system for management of acute nasal fracture in response to the coronavirus disease 2019 pandemic
Authors: Devakumar Haran , Tailor Bhavesh , Low Dana , Moin Sarah , Ioannidis Dimitrios 
Published: November 2022

Abstract
Background
Acute nasal fracture is a common referral to ENT outpatient clinic. During the Covid-19 pandemic, NHS outpatient services were increasingly stretched and placed patients and staff at risk of Coronavirus. Virtual clinic appointments provided an effective method for reducing Covid-19 risk and improving the efficiency of outpatient services. We sought to implement a telephone triage system for the assessment of nasal fractures.
Method
A telephone triage pathway for nasal fracture was implemented in October 2021. Data on nasal fracture appointments and outcomes were retrospectively collected for 2 months prior to, and after, the introduction of the telephone triage pathway. All patients with suspected nasal fracture referred to ENT by the Emergency Department at Colchester Hospital were included.
Results
At baseline, 32 patients were referred for face-to-face (F2F) clinic, 20 (62%) attended and 12 (38%) did-not-attend (DNA). Of those who attended, 17 (85%) were managed conservatively and 3 (15%) had manipulation under anaesthetic (MUA). 24 patients were included in the telephone triage pathway, 13 (54%) attended and 11 (46%) DNA. Of those who attended, 11 (84%) were discharged and 2 (16%) were brought in for F2F assessment. One was managed conservatively and the other had a MUA (8%). The increase in DNA rate from the F2F pathway to the telephone triage pathway was not statistically significant.
Conclusion
Our data suggests that the telephone triage system for nasal fracture management results in fewer F2F appointments. This reduces COVID-19 transmission to the public and hospital staff but also improves utilisation of outpatient capacity.
Impact of intermittent supply on water meter accuracy
Authors: Ferrante Marco , Rogers Dewi , Mugabi Josses , Casinini Francesco 
Published: November 2022

Abstract
Supply interruptions are a common occurrence in water systems and are particularly prevalent in developing countries. During the system filling, the air that entered into the pipes when the supply was closed is expelled through any fissures including service pipes. When a meter is installed, the airflow can cause inaccuracies, over-reading, and reliability issues. This paper investigates experimentally the impact of the airflow on water meter performance during filling by means of a laboratory set-up, using pipes with diameters comparable to those of a real water system. The impact of the airflow on the accuracy and reliability of the water meters is discussed and the potential for over-reading is estimated.
Towards improving the hydrologic design of permeable pavements
Authors: Abdalla Elhadi Mohsen Hassan , Muthanna Tone Merete , Alfredsen Knut , Sivertsen Edvard 
Published: November 2022

Abstract
The common approach to the hydrologic design of permeable pavements (PPs) uses synthetic rainfall events. This study assessed the validity of the design approach using synthetic rainfall events for undrained PP. Synthetic rainfall events (25-year return period) were used to design undrained pavements for five Norwegian cities. The effectiveness of these pavements was tested using long-term simulation (12–30 years) with high temporal resolution (1 min). The Storm Water Management Model (SWMM) was used to generate time series of surface runoff for PPs and flow duration curves were applied to analyse the hydrological performances. Designing PP using synthetic rainfall events was found to underestimate the storage layer depth of the permeable pavements leading to the frequent occurrence of surface runoff, which is considered a failure of the hydrologic design of undrained pavements. Long-term simulation of surface runoff was found to provide valuable information for the hydrologic design of PP and can be used as a basis for the PP hydrologic design. In the future, it is recommended to use long-term precipitation data generated from climate change models to incorporate the effect of climate change in the design of PP.
Interactive hydrological modelling and simulation on client-side web systems: an educational case study
Authors: Ewing Gregory , Mantilla Ricardo , Krajewski Witold , Demir Ibrahim 
Published: November 2022

Abstract
Computational hydrological models and simulations are fundamental pieces of the workflow of contemporary hydroscience research, education, and professional engineering activities. In support of hydrological modelling efforts, web-enabled tools for data processing, storage, computation, and visualization have proliferated. Most of these efforts rely on server resources for computation and data tasks and client-side resources for visualization. However, continued advancements of in-browser, client-side compute performance present an opportunity to further leverage client-side resources. Towards this end, we present an operational rainfall-runoff model and simulation engine running entirely on the client side using the JavaScript programming language. To demonstrate potential uses, we also present an easy-to-use in-browser interface designed for hydroscience education. Although the use case presented here is self-contained, the core technologies can extend to leverage multi-core processing on single machines and parallelization capabilities of multiple clients or JavaScript-enabled servers. These possibilities suggest that client-side hydrological simulation can play a central role in a dynamic, interconnected ecosystem of web-ready hydrological tools.
The Sphingolipids Metabolism Mechanism and Associated Molecular Biomarker Investigation in Keloid
Authors: Zang Chengyu , Liu Yanxin , Chen Huaxia 
Published: November 2022

Background:Sphingolipid metabolism plays important roles in maintaining cell growth and signal transduction. However, this pathway has not been investigated in keloid, a disease characterized by the excessive proliferation of fibroblasts.Methods:Based on the expression profiles of three datasets, the differentially expressed genes (DEGs) were explored between keloid fibroblasts and normal fibroblasts. Metabolism-related genes were obtained from a previous study. Then, enrichment analysis and protein-protein interaction (PPI) network analysis were performed for genes. Differences in metabolism-related pathways between keloid fibroblasts and normal fibroblasts were analyzed by the gene set variation analysis (GSVA). Quantitative PCR was used to confirm the expression of key genes in keloid fibroblast.Results:A total of 42 up-regulated co-DEGs and 77 down-regulated co-DEGs were revealed based on three datasets, and were involved in extracellular matrix structural constituent, collagencontaining extracellular matrix and sphingolipid metabolism pathway. A total of 15 metabolism- DEGs were screened, including serine palmitoyltransferase long chain base subunit (SPTLC) 3, UDP-glucose ceramide glucosyltransferase (UGCG) and sphingomyelin synthase 2 (SGMS2). All these three genes were enriched in the sphingolipid pathway. GSVA showed that the biosynthesis of glycosphingolipids (GSLs) in keloid fibroblasts was lower than that in normal fibroblasts. Quantitative PCR suggested SPTLC3, UGCG and SGMS2 were regulated in keloid fibroblasts.Conclusion:Sphingolipids metabolism pathway might take part in the disease progression of keloid by regulating keloid fibroblasts. SPTLC3, UGCG and SGMS2 might be key targets to investigate the underlying mechanism.
The Antimicrobial Effect Against Multi-drug Resistant Bacteria of the
SK4 Peptide: A Novel Hybrid Peptide of Cecropin-A and BMAP-27
Authors: Masadeh Majed M. , Laila Salam Abu , Haddad Razan , Alzoubi Karem , Alhaijaa Ahmad Abu , Alrabadi Nasr 
Published: November 2022

Background:
Antibiotic-resistant is considered one of the critical health challenges in the
management of infectious diseases. Resistant bacterial strains to different antibacterial agents have
been spread worldwide. Anti-microbial peptides (AMPs), also called host defense peptides, have a
broad spectrum of activity and targeting even to multi-drug resistant (MDR) bacteria, therefore, they
have been extensively studied and developed as novel therapeutic antibacterial agents.

Objectives:
The study aims to design a novel SK4 hybrid peptide with improved characteristics compared
with the BMAP-27 and Cecropin-A natural parents’ peptides.

Methods:
The bioinformatic analysis of the SK4 peptide compared with the parents BMAP-27 and
Cecropin-A peptides was conducted and fully characterized using specialized software. The antimicrobial
and antibiofilm activity of SK4 was tested, followed by a synergistic study with five conventional
antibiotics (Levofloxacin, Rifampicin, Chloramphenicol, Doxycycline, and Ampicillin). Finally,
the cytotoxicity against horse erythrocytes and mammalian cells was assessed.

Results:
The SK4 peptide demonstrated broad-spectrum antimicrobial activity against both grampositive
and gram-negative bacteria. The peptide also did not show any hemolytic activity even when
used at concentrations ten folds higher than its MICs value. The SK4 peptide also showed a synergistic
mode of action when combined with antibiotics, which resulted in a significant decrease in MIC
values for both the peptide and the antibiotics.

Conclusions:
The SK4 peptide showed better activity, selectivity, and safety profile than the parent
peptides, making it a novel potential treatment for MDR bacterial infections.
Pyrazole as an Anti-Microbial Scaffold: A Comprehensive Review
Authors: Kaur Parminder , Arora Vimal 
Published: November 2022

Abstract:Pathogenic microorganisms cause serious and lethal infectious diseases. Numerous antimicrobial agents have been developed during the last few decades to treat these infectious diseases, but these are still expanding worldwide. Moreover, microorganisms are developing resistance against commercially available medicines. So, antimicrobial resistance is expanding as the most serious health threat particularly in developing countries, due to the easier availability of anti-microbial drugs. Therefore, the scarcity of effective antibiotics suggests the pressing demand for new anti-microbial agents. Modern drug discovery regarded heterocyclic compounds as its core due to their striking structural characteristics. Pyrazole is considered as a significant heterocyclic nucleus in modern drug development. This review brings a considerable summary regarding derivatives of pyrazole developed over the last decade for their anti-microbial action, along with docking studies carrying an expectation that it will be beneficial for medicinal chemists working in anti-microbial drug development.
The Effect of Haptonomy Intervention on Fear of Childbirth and Maternal- Fetal Attachment Among Primigravid Women
Authors: Dorosti Elham , Nourizadeh Roghaiyeh , Mehrabi Esmat , Herizchi Sepideh 
Published: November 2022

Background:Fear of childbirth (FOC) is considered as one of the factors influencing the increase of elective cesarean section. The appropriate solution to reduce the FOC has not yet been identified.Objective:The present study aimed to evaluate the effect of haptonomy intervention on FOC and maternal-fetal attachment (MFA) among primigravid women‎.Methods:This quasi-experimental study was conducted on 68 primigravid women with a gestational age of 24-28 weeks who referred to health centers in Tabriz, Iran with a FOC score above 65. Participants were randomly assigned into the intervention and control groups. The intervention group (n=34) received haptonomy in 5 sessions, once a week for 45-60 minutes, and control group received an information pamphlet about pain management options in labor and fetal development during pregnancy. The data were collected using Wijma Delivery Expectancy/Experience Questionnaire-version A, Cranley’s MFA Scale, and Revised Pregnancy Related Anxiety Questionnaire, before the intervention and at gestational age of 35-37 weeks. The data were analyzed using Chi-square, independent t-test, and ANCOVA.Findings:After intervention and controlling the effect of baseline score, the mean score of FOC in the intervention group was significantly lower than that in the control group [Adjusted mean difference (AMD): -23.67, 95% CI: - 28.12 to -19.23, P =0.001]. Further, the mean score of MFA indicated a significant difference between the two groups [AMD: 10.12, 95% CI: 6.44 to 13.8, p <0.001].Conclusion:The results of the present study revealed the effectiveness of the haptonomy intervention in reducing FOC and increasing MFA. Therefore, the use of haptonomy intervention is recommended among mothers with high and severe FOC and low MFA.
Characterization, Potential Prognostic Value, and Immune Heterogeneity
of Cathepsin C in Diffuse Glioma
Authors: Liu Hui , Jiang Xingjun , Ren Caiping , Zhou Quanwei , Li Shasha , Yan Xuejun , Zhu Hecheng , Liu Weidong , Guo Youwei , Xu Hongjuan , Yin Wen , Li Xuewen , Yang Qian 
Published: November 2022

Aims:
Diffuse glioma is the most frequent intracranial tumor and remains universally lethal. Prognostic biomarkers have remained a focus in diffuse glioma during the last decades. More reliable predictors to adequately characterize the prognosis of diffuse glioma are essential. Cathepsin C (CTSC), a lysosomal cysteine protease, is an essential component of the lysosomal hydrolase family, with their potential roles in diffuse glioma remaining to be characterized

Objective:
We aimed to investigate the performance of CTSC in predicting prognosis and therapeutic targets in diffuse glioma.

Method:
The expression profile of CTSC in multiple tumors and more than 2000 glioma samples with corresponding clinical data were collected through authoritative public databases. The expression level of CTSC was evaluated by qPCR and IHC. The prognostic value of CTSC was assessed using the univariate and multivariate cox regression analysis. The ESTIMATE R package was used to evaluate the immune and stromal scores based on the gene expression profile. The CIBERSORT was applied to evaluate the relative levels of 22 immune cell subtypes by using the R package 'CIBERSORT' to define the cell composition of tumor tissues. In addition, the MCP counter was used to assess the absolute abundance of neutrophils.

Result:
CTSC was aberrantly expressed and significantly correlated with clinical outcomes in multiple tumors. CTSC was heterogeneously expressed across histologic types and tumor grades for diffuse glioma and highly enriched in IDH or IDH1-wildtype glioma. CTSC was positively associated with immune and stromal scores and infiltrating levels of M2 macrophages and neutrophils and negatively associated with infiltrating levels of NK cells. Additionally, CTSC was closely correlated with some immune checkpoint molecules, including CD276, CD80, CD86 and PD-L2.

Conclusion:
Conclusion: CTSC was involved in shaping the immunosuppressive microenvironment and acted as an independent indicator of a poor prognosis in diffuse glioma. Targeting CTSC for glioma therapies might provide promising prospects.