bluuebunny/crossref_metadata_2025_split huggingface dataset:
SCANET: Improving multimodal representation and fusion with sparse‐ and cross‐attention for multimodal sentiment analysis
Authors: Wang Hao , Yang Mingchuan , Li Zheng , Liu Zhenhua , Hu Jie , Fu Ziwang , Liu Feng 
Published: June 2022

AbstractLearning unimodal representations and improving multimodal fusion are two cores of multimodal sentiment analysis (MSA). However, previous methods ignore the information differences between different modalities: Text modality has high‐order semantic features than other modalities. In this article, we propose a sparse‐ and cross‐attention (SCANET) framework which has asymmetric architecture to improve performance of multimodal representation and fusion. Specifically, in the unimodal representation stage, we use sparse attention to improve the representation efficiency of two modalities and reduce the low‐order redundant features of audio and visual modalities. In the multimodal fusion stage, we design an innovative asymmetric fusion module, which utilizes audio and visual modality information matrix as weights to strengthen the target text modality. We also introduce contrastive learning to effectively enhance complementary features between modalities. We apply SCANET on the CMU‐MOSI and CMU‐MOSEI datasets, and experimental results show that our proposed method achieves state‐of‐the‐art performance.
Anti‐Dengue Screening on Several Vietnamese Medicinal Plants: Experimental Evidences and Computational Analyses
Authors: Thao Tran Thi Phuong , Co Nguyen Quang , Anh Ho Ngoc , Luu Nguyen Thi , Hau Vu Thi Bich , Thuy Nguyen Thi Thu , Chien Tran Van , Anh Nguyen The , Bui Thanh Q. , Cuong To Dao , Quy Phan Tu , Triet Nguyen Thanh , Sung Tran Van , Nhung Nguyen Thi Ai 
Published: June 2022

AbstractWorldwide, medicinal plants have been known for economic and geographical advantages, thus possibly holding potentiality against dengue hemorrhagic fever. The methanol/water extracts from different parts of fourteen Vietnam‐based plant species were subjected for experimental screening on anti‐dengue activity using baby hamster kidney cells (BHK21) and plaque reduction neutralisation test (PRNT). Firstly, the methanol/water extracts were tested against serotype dengue virus DENV‐1. Seven out from nineteen extracts show the PRNT50 values less than 31.25 μg/mL. Four of the above extracts namely from Euphorbia hirta, Cordyline terminalis, Carica papaya, and Elaeagnus latifolia were chosen for testing against the serotype DENV‐2. All of them exhibit good activity with the PRNT50 values less than 31.25 μg/ml, which were further fractionated to obtain hexane, ethyl acetate and butanol fractions. Anti‐dengue virus activity of the fractions against four serotypes DENV‐1, −2, −3 and −4 was evaluated. As results, the ethyl acetate fraction of Elaeagnus latifolia is highly active against all four serotype viruses. The structural formulae of its nine constituents were input for molecular docking simulation. The docking‐based order for static inhibitability is 6‐3L6P>7‐3L6P>9‐3L6P>2‐3L6P>3‐3L6P≈5‐3L6P>9‐3L6P>1‐3L6P>8‐3L6P; QSARIS‐based analysis reveals the biocompatibility of the most promising ligands (4–7); ADMET‐based analysis expects their pharmacological suitability. Exceptional finding on 2‐3LKW hydrophilic interaction at Lys43 (with the associated Gibbs free energy of −10.3 kcal mol−1) raises an open explanation for inhibitory effects. The results encourage further investigations for more in‐depth mechanisms and drug development, such as in vitro enzyme assays or in vitro clinical trials with natural substances from E. latifolia.
A unique case of tachycardia‐mediated cardiomyopathy in a patient misusing anabolic steroids
Authors: Adhikari Govinda , Khan Ashiya , Shams Nasheed , Hassan Mustafa H. , Kunadi Arvind 
Published: June 2022

AbstractA 54‐year‐old male patient with history of anabolic androgenic steroid (AAS) misuse presented to the emergency department with new‐onset atrial fibrillation and severely reduced ejection fraction. Cardiac catheterization revealed normal coronaries. He underwent cryo‐balloon ablation with subsequent conversion to sinus rhythm. After appropriate guideline‐directed medical management, ejection fraction improved on follow‐up.
Platinum‐Rare Earth Alloy Electrocatalysts for the Oxygen Reduction Reaction: A Brief Overview
Authors: Campos‐Roldán Carlos A. , Jones Deborah J. , Rozière Jacques , Cavaliere Sara 
Published: June 2022

AbstractThe development of highly active and long‐term stable electrocatalysts for the cathode of proton‐exchange membrane fuel cells (PEMFC) is a paramount requirement for high performance and durable PEMFC stacks. In this regard, alloying Pt with rare earth metals (REM) has emerged as a promising approach. This short review summarizes and discusses the most relevant advances on Pt‐REM alloy electrocatalysts, from bulk polycrystalline surfaces to carbon supported nanostructures, for the oxygen reduction reaction (ORR), and their implementation in PEMFCs, and is a starting point to establish the challenges in synthesis and design and properties goals for novel Pt‐REM alloys.
Improving the Glucose to Fructose Isomerization via Epitaxial‐Grafting of Niobium in UIO‐66 Framework
Authors: Kumar Kar Ashish , Srivastava Rajendra 
Published: June 2022

AbstractGlucose to fructose transformation is an essential transformation for the success of biorefinery. Herein, the epitaxial‐grafting of Nb in UIO‐66 significantly improved the fructose yield. Post‐synthesis incorporating Nb in the UIO‐66 phenomenally improved the glucose conversion from 31.1 % to 71.8 % and fructose selectivity from 38.2 % to 71.2 %. The incorporation of Nb was confirmed from the FTIR, HR‐TEM investigation, EDX analysis, and elemental mapping. The XPS analysis distinctly stated the successful incorporation of Nb and generation of Zr−O−Nb oxo clusters in the UIO‐66 framework. The NH3‐TPD provided distinguishable information about the chemical interaction of Nb with the UIO‐66 framework that resulted in the increase of the acid strength after the Nb incorporation in the UIO‐66 catalyst. The content of Nb and reaction parameters, especially temperature and duration, control the glucose to fructose isomerization over glucose to mannose epimerization. The structure‐activity relationship was established, and a reaction mechanism was proposed. The catalyst was recycled five times with only a lower decrease in the fructose yield (47.3 % to 42.2 %) than several reported MOFs catalysts. The activity of the developed catalyst was higher or similar to the reported catalysts. The successful grafting of Nb demonstrates that by swiftly modifying the acidity of the catalyst, a superior activity can be achieved.
Impact of Fluoroalkyl Substituents on the Physicochemical Properties of Saturated Heterocyclic Amines
Authors: Melnykov Kostiantyn P. , Tavlui Olha , Skreminskiy Artem , Kuchkovska Yuliya O. , Grygorenko Oleksandr O. 
Published: June 2022

AbstractThe physicochemical properties (pKa(H), log P, and aqueous solubility) of fluoroalkyl‐substituted heterocyclic amines were profiled to facilitate the amines’ rational application in medicinal chemistry research. The features of fluorine‐containing compounds were compared to those of the corresponding parent non‐fluorinated heterocycles and the corresponding fluorinated n‐alkylamines. Amine basicity was observed to change in a monotonic fashion depending on the fluorination pattern. Although the introduction of fluoroalkyl groups had complex effects on the lipophilicity and aqueous solubility of the compounds, possible contributions of the fluorination pattern, ring size, and conformation of the substituent in the ring were addressed for a series of derivatives. The summarized data provide a useful guideline for the application of fluorinated motifs for fine‐tuning a compound's properties related to drug discovery.
Selective Iron Catalyzed Synthesis of N‐Alkylated Indolines and Indoles
Authors: Wu Jiajun , Tongdee Satawat , Cordier Marie , Darcel Christophe 
Published: June 2022

AbstractWhereas iron catalysts usually promote catalyzed C3‐alkylation of indole derivatives via a borrowing‐hydrogen methodology using alcohols as the electrophilic partners, this contribution shows how to switch the selectivity towards N‐alkylation. Thus, starting from indoline derivatives, N‐alkylation was efficiently performed using a tricarbonyl(cyclopentadienone) iron complex as the catalyst in trifluoroethanol in the presence of alcohols leading to the corresponding N‐alkylated indoline derivatives in 31–99 % yields (28 examples). The one‐pot, two‐step strategy for the selective N‐alkylation of indolines is completed by an oxidation to give the corresponding N‐alkylated indoles in 31–90 % yields (15 examples). This unprecedented oxidation methodology involves an iron salt catalyst associated with (2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl (TEMPO) and a stoichiometric amount oft‐BuOOH at room temperature.
A Gas Generating System for Complex Gas Mixtures – Multifunctional Application in PTR Method Optimization and Downstream Methanol Synthesis
Authors: Pollok Corina Helene , Göbel Christoph , Gómez Jorge Iván Salazar , Schlögl Robert , Ruland Holger 
Published: June 2022

AbstractThe multifunctional applicability of a gas mixing system is presented within the scope of Carbon2Chem® for the simulation of steel mill flue gases and their application in downstream processes. A special focus is set on the parallel operation of the gas mixing system to enable PTR‐MS method optimization and methanol synthesis with simulated real gas matrices. Information is gathered for the design of downstream processes and their application, where methanol synthesis is chosen as a model reaction. A proof‐of‐principle study is presented where operation of a catalytic reactor setup in combination with the gas mixing system and a compressor generate reproducible results. The addition of potential trace components in methanol synthesis is exemplarily demonstrated using ammonia. With respect to the PTR‐MS application, the dosing of two calibration gas standards, toluene and carbonyl sulfide, via the gas mixing system were analyzed in detail. The obtained results give insight into its applicability to simulate traces and enables the further development of analytical methods for the analysis of trace impurities in the ppb and ppt range in complex gas mixtures.
Barriers and opportunities to measuring oncology patient navigation impact: Results from the National Navigation Roundtable survey
Authors: Battaglia Tracy A. , Fleisher Linda , Dwyer Andrea J. , Wiatrek Dawn E. , Wells Kristen J. , Wightman Patrick , Strusowski Tricia , Calhoun Elizabeth ,   the National Navigation Roundtable Evidence‐Based Task Group
Published: June 2022

BackgroundPatient navigation improves cancer care delivery for those most at risk for poor outcomes. Lack of sustainable funding threatens the full integration of navigation services into health care delivery systems. Standardized navigation metrics that document impact and identify best practices are necessary to support sustainability.MethodsThe National Navigation Roundtable administered a web‐based, cross‐sectional survey to oncology patient navigation programs to identify barriers and facilitators to the use of navigation metrics. The 38‐item survey asked about data‐collection practices and specific navigation metrics used by the program. Exploratory and descriptive statistics were used to identify factors associated with data collection and reporting.ResultsSeven hundred fifty respondents from across the country represented navigation programs across the continuum of care. Although 538 respondents (72%) reported participating in routine data collection, only one‐half of them used data for reporting purposes. For the 374 programs that used electronic health records, only 40% had discrete, reportable navigation fields, and 25% had an identifier for navigated patients. Program funding was identified as the only characteristic associated with data collection, whereas the type of data collected was associated with work setting, participation in alternative payment models, and where on the continuum navigation services are provided. Respondents participating in an oncology accreditation program were more likely to collect specific outcome metrics across the continuum and to use those data for reporting purposes. The most common barriers to data collection were time (55%) and lack of support for complex data systems and/or platforms (50%).ConclusionsInconsistent data collection and reporting of oncology navigation programs remain a threat to sustainability. Aligning data collection with oncology accreditation, funding, and reimbursement is a viable path forward.
Exploring classes of cancer patient navigators and determinants of navigator role retention
Authors: Garcia‐Alcaraz Cristian , Roesch Scott C. , Calhoun Elizabeth , Wightman Patrick , Mohan Prashanthinie , Battaglia Tracy A. , Cobian Aguilar Rosa , Valverde Patricia A. , Wells Kristen J. ,   the National Navigation Roundtable Evidence‐Based Task Group
Published: June 2022

BACKGROUNDIn the current nationwide study, the authors used latent class analysis (LCA) to identify classes of cancer patient navigators (CPNs) and examined whether class membership and 12 indicators were related to navigator role retention.METHODSBy using data from 460 CPNs in the United States, LCA identified classes (ie, homogenous subgroups) of CPNs with the following indicators: type of CPN (clinical vs nonclinical), education level, area(s) of the cancer care continuum in which the CPN provided patient navigation, region and urbanity where the CPN provided services, organizational work setting, and patient navigation program funding source. The associations of navigator retention with class membership and each indicator were examined using χ2 tests.RESULTSLCA identified 3 classes of CPNs. Classes 1 and 3 were conceptualized as distinct, homogeneous subgroups of clinical CPNs that appeared to differ mainly on their likelihood of engagement in outreach, survivorship, palliative care, and end‐of‐life patient navigation. Class 2 was conceptualized as a nonclinical CPN subgroup that was distinct primarily based on their high endorsement of employment in programs, which are at least partially funded by grants and engagement in earlier stages of patient navigation (eg, early detection). The provision of survivorship and treatment patient navigation was related to navigator role retention, with senior CPNs providing these patient navigation services more than novice CPNs.CONCLUSIONSThe current study highlights 3 distinct classes of CPNs, provides initial information regarding determinants of navigator retention, and makes several recommendations for future patient navigation research.
Flexibility, adaptation, and roles of patient navigators in oncology during COVID‐19
Authors: Valverde Patricia A. , Kennedy Sheldon Lisa , Gentry Sharon , Dwyer Andrea J. , Saavedra Ferrer Elba L. , Wightman Patrick D. ,   the National Navigation Roundtable Workforce Development Task Group
Published: June 2022

BackgroundThe impact of COVID‐19 on cancer care during the first 6 months of the pandemic has been significant. The National Navigation Roundtable Workforce Development Task Group conducted a national survey to highlight the role of patient navigators (PNs).MethodsAn anonymous online survey captured how cancer care navigation changed during 2 phases: 1) March 13 to May 31, 2020; and 2) June 1 to September 4, 2020. Differences between the 2 time periods for categorical variables were assessed using χ2 tests, and 1‐way analyses of variance were used for ordinal variables.ResultsAlmost one‐half of PNs expected changes in duties (49%) during phase 1. By phase 2, PNs showed greater confidence in retaining PN work (P < .001) and reduced changes to duties (P < .01). PNs reported new training on COVID‐19 and telehealth during phase 1 (64% and 27%, respectively) and phase 2 (54% and 19%, respectively). Significant decreases in service delays were identified by phase 2 for cancer screening (P < .001), preventive care (P < .001), medical treatment (P < .01), cancer treatment (P < .001), and cancer survivorship services (P < .01). PNs reported that the top patient issues were COVID‐19 concerns, medical care disruptions, and finances, and there were decreases in medical care disruptions (P < .01) during phase 2. PNs addressed myths related to mask use, COVID‐19 spread, disbelief, risk, clinical changes, transmission prevention, and finances/politics.ConclusionsThe PN role demonstrated resiliency and adaptability. Both clinical and nonclinical oncology PNs identified key patient needs and can provide connections with patient populations that have been economically and socially marginalized, which is necessary to build trust throughout the pandemic.
An Amphiphilic Double‐Brush Polymer Hydrogel for Sustained Release of Small Molecules and Biologics: Insulin Delivering‐Hydrogel to Control Hyperglycemia
Authors: Dhayani Ashish , Bej Sujoy , Mudnakudu‐Nagaraju Kiran K. , Chakraborty Saheli , Srinath Preethem , Kumar Ashok H. , PS Ann Maria , Khristi Anand , Ramakrishnan S. , Vemula Praveen Kumar 
Published: June 2022

AbstractDiabetic patients need to take multiple insulin injections in a day to achieve efficient glycemic control. However, repeated injections can cause pain and discomfort for patients. Therefore, we have developed an amphiphilic double‐brush polymer‐based hydrogel (DBP‐hydrogel) that can encapsulate insulin and can be injected subcutaneously. Additionally, we have demonstrated the robust nature of DBP‐hydrogel by encapsulating small molecular drugs and large biological agents. Using a streptozotocin‐induced type 1 diabetic mouse model, we have demonstrated that a single injection of the insulin‐loaded hydrogel can efficiently control hyperglycemia for 24 hours, whereas 5 repeated injections of free‐insulin (commercial formulations) are required to achieve a similar level of glycemic control. This novel DBP‐hydrogel can stabilize encapsulated insulin without losing its activity for at least 90 days, which may have a huge impact in avoiding cold chain supply. Furthermore, a series of in vitro and in vivo experiments suggest that newly developed DBP‐hydrogel is highly biocompatible and does not cause immune response and inflammation.
First‐in‐Human Single‐Ascending‐Dose, Multiple‐Dose, and Food Interaction Studies of NRD.E1, an Innovative Nonopioid Therapy for Painful Diabetic Peripheral Neuropathy
Authors: Tiecke Eva , Rainisio Maurizio , Guentert Theodor , Müller Stephan , Hochman Liat , Kaplan Eli , Mangialaio Sara 
Published: June 2022

AbstractPainful diabetic peripheral neuropathy is characterized by burning, stabbing, or electric shock–type pain, which severely impacts day‐to‐day functioning and quality of life. Here, we report the results of 3 phase I studies with NRD135S.E1 (referred to as NRD.E1), a new, orally available chemical entity, presently developed for the treatment of painful diabetic peripheral neuropathy. The first study was a first‐in‐human, randomized, placebo‐controlled, single‐ascending‐dose study, where NRD.E1 was administered to healthy male subjects in single dosages ranging from 300 to 1200 mg. The second study was a randomized, placebo‐controlled multiple‐dose study, where healthy male subjects received 300 mg of NRD.E1 once daily for 5 consecutive days. The third study was an open‐label food interaction study in healthy men and women following a crossover design, where NRD.E1 was administered under fed and fasted conditions at 40 mg. The studies revealed dose‐dependent absorption, increased exposure to NRD.E1 when administered with food, and no relevant accumulation after once‐daily administration. All 3 phase I studies consistently showed rapid absorption of orally administered NRD.E1 followed by fast elimination, mainly via metabolization (glucuronidation), and small secondary increases in plasma concentrations. NRD.E1 was well tolerated, with no subject discontinuation due to treatment‐emergent adverse events in any study.
Periapical status in patients affected by osteoporosis: A retrospective clinical study
Authors: Cadoni Erika , Ideo Francesca , Marongiu Giuseppe , Mezzena Silvia , Frigau Luca , Mela Quirico , Capone Antonio , Duncan Henry F. , Cotti Elisabetta 
Published: June 2022

AbstractObjectivesTo assess the periapical status in patients with osteoporosis (OP) treated with denosumab (D), bisphosphonates (BPs), or not on medication, and to understand if these conditions influence the prevalence and the progression of apical periodontitis (AP).Material and MethodsSeventy‐six patients with OP alone or treated with D, or BPs, formed the study group (O), and those from 76 patients matched for age and sex, without diseases, and not taking medications, constituted the control (C) in this retrospective case−control study. The data from the complete clinical and radiographic examination, medical history, decayed, missing, and filled teeth (DMFT), and periapical index score (PAI) were recorded for each patient. Wilcoxon rank test, χ2, and Student's t test were used as appropriate.ResultsThe prevalence of AP was similar in O and C. Furthermore, AP was significantly more frequent in root canal‐treated teeth in O patients (p = .03).ConclusionsOP does not appear to be associated with the development of AP. Moreover, the increased prevalence of AP in root canal‐treated teeth in O patients highlights a possible relationship between the healing dynamics of the disease post‐therapy and the patients' medication. A larger sample is needed to confirm these findings.
Spring snowmelt affects changes of alpine tundra vegetation in Changbai Mountains
Authors: Li Yan , He Hong S. , Zong Shengwei , Sun Hang 
Published: June 2022

AbstractClimate and environmental changes have caused changes in alpine tundra worldwide in recent decades. However, the roles of snow cover on tundra vegetation change remain less studied. There were obvious changes of alpine tundra vegetation, such as herbaceous encroachment and shrub expansion reported in Changbai Mountains in recent decades. This study investigates the relationship between snow cover and vegetation change (1988–2017) in alpine tundra of the Changbai Mountains by analysing the hydrological distribution of spring snowmelt in the tundra. We mapped the wet snow extent using Sentinel‐1 synthetic aperture radar (SAR) spaceborne data and estimated the snow water equivalent (SWE). We proposed a measure of relative water accumulation (RWA), which was determined by both rainfall and SWE, to represent water flowing through each pixel. We found strong correlations between RWA and vegetation change in different mountain aspects. Spring snowmelt leads to inter‐mountain aspect differences in hydrological distribution, with the western aspect showing a significant higher RWA than the eastern and northern aspects, which could attribute to the greater vegetation change in the western mountain aspect. Our results suggest that the distribution of snow in alpine tundra and the different mountain aspects hydrological conditions have important implications for the study of vegetation change in alpine tundra.