bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of 90 day home time among patients with low baseline ASPECTS undergoing endovascular thrombectomy: results from Alberta’s Provincial Stroke Registry (QuICR)
Authors: Singh Nishita , Holodinsky Jessalyn K , Kashani Nima , McDonough Rosalie V , Bala Fouzi , Horn MacKenzie , Stang Jillian , Demchuk Andrew M , Hill Michael D , Almekhlafi Mohammed A 
Published: July 2022

BackgroundThe benefit of endovascular thrombectomy (EVT) in stroke patients with a low baseline Alberta Stroke Program Early CT Score (ASPECTS, ≤5) is uncertain. We aim to use random forest regression modeling to predict 90 day home time in patients with low ASPECTS.MethodsWe used the Quality Improvement and Clinical Research (QuICR) provincial stroke registry and administrative data from southern Alberta to identify patients who underwent EVT in our center from July 2015 to November 2020. Baseline ASPECTS on non-contrast CT and CT angiography data were scored by a two physician consensus. The primary outcome was the predicted 90 day home time (the number of nights a patient is back at their premorbid living situation without an increase in level of care within 90 days of the stroke) using random forests regression. Estimates were generated using 200 bootstrapped datasets. Covariate contribution to home time was determined using partial dependence plots.ResultsOf 657 EVT patients, 85 (12.9%) had baseline ASPECTS ≤5 (mean age 70.9 years, 44.7% women, 93.9% good–moderate collaterals, 60% M1–middle cerebral artery occlusion). Using partial dependence estimates, mean predicted home times were similar in the low ASPECTS (44.3 days) versus higher ASPECTS (43.1) groups. Factors predicting lower 90 day home time in this population were diabetes mellitus (−8.8 days), hypertension (−5.7 days), and atrial fibrillation (−3.6 days). There was no meaningful difference in predicted 90 day home time by sex, baseline National Institutes of Health Stroke Severity Scale score, occlusion site, tandem lesion, collateral grade or thrombolysis.ConclusionsPatients with low ASPECTS who are selected for EVT using demographic and clinical profiles similar to higher ASPECTS patients achieved comparable outcomes.
Exploring the relationship between resting-state intra-network connectivity and accelerometer-measured physical activity in pediatric concussion: a cohort study
Authors: Sharma Bhanu , Obeid Joyce , DeMatteo Carol , Noseworthy Michael D. , Timmons Brian W. 
Published: July 2022

Our objective was to explore the association between resting-state functional connectivity and accelerometer-measured physical activity in pediatric concussion. Fourteen children with concussion (aged 14.54 ± 2.39 years, 8 female) were included in this secondary data analysis of a larger study. Participants had neuroimaging at 15.3 ± 6.7 days postinjury and subsequently a mean of 11.1 ± 5.0 days of accelerometer data. Intra-network connectivity of the default mode network (DMN), sensorimotor network (SMN), salience network (SN), and frontoparietal network (FPN) was computed using resting-state MRI. We found that, per general linear models (GLMs), only intra-network connectivity of the DMN was associated with physical activity levels. More specifically, increased intra-network connectivity of the DMN was significantly associated with higher levels of subsequent accelerometer-measured light physical activity (LPA; F(2, 11) = 7.053, p = 0.011, Ra2 = 0.562; β = 0.469), moderate physical activity (MPA; F(2, 11) = 6.159, p = 0.016, Ra2 = 0.528; β = 0.725), and vigorous physical activity (VPA; F(2, 11) = 10.855, p = 0.002, Ra2 = 0.664; β = 0.792). Intra-network connectivity of the DMN did not significantly predict sedentary time. Therefore, these preliminary findings suggest that there is a positive association between the intra-network connectivity of the DMN and device-measured physical activity in children with concussion.
Effects of aldo-keto reductase family 1 member A on osteoblast differentiation associated with lactate production in MC3T3-E1 preosteoblastic cells
Authors: Kuo Chia-Hsiao , Lee Inn-Chi , Huang Bo-Jun , Chen Chuan-Mu , Liou Ying-Ming 
Published: July 2022

Aldo-keto reductase family 1 member A (AKR1A) is an NADPH-dependent aldehyde reductase widely expressed in mammalian tissues. In this study, induced differentiation of MC3T3-E1 preosteoblasts was found to increase AKR1A gene expression concomitantly increased NOx− (nitrite + nitrate), increased glucose uptake, increased [NAD(P)+]/[NAD(P)H] and lactate production but decreased reactive oxygen species (ROS) without changes in endothelial nitric oxide synthase (eNOS) expression in differentiated osteoblasts (OBs). A study using gain- and loss-of-function MC3T3-E1 cells indicated that AKR1A is essential for modulating OB differentiation and gene expression of collagen 1 A1, receptor activator of nuclear factor kappa-B ligand, and osteoprotegerin in OBs. Immunofluorescence microscopy also revealed that changes in AKR1A expression altered extracellular collagen formation in differentiated OBs. Consistently, analyses of alkaline phosphatase activity and calcium deposits of matrix mineralization by Alizarin Red S staining verified that AKR1A is involved in the regulation of OB differentiation and bone matrix formation. In addition, AKR1A gene alterations affected the levels of NOx−, eNOS expression, glucose uptake, [NAD(P)+]/[NAD(P)H] dinucleotide redox couples, lactate production, and ROS in differentiated OBs. Herein, we report that AKR1A-mediated denitrosylation may play a role in the regulation of lactate metabolism as well as redox homeostasis in cells, providing an efficient way to quickly gain energy and to significantly reduce oxidative stress for OB differentiation.
Mechanical behavior of Malan loess under unconfined compression conditions
Authors: He Shengdi , Li Yanrong , Zhang Shuai 
Published: July 2022

Loess landslides result in heavy casualties and economic losses. Among them, toppling is one of the predominant failure modes in Malan loess. Loess toppling failure normally arises from deep vertical cracks, which tend to develop in the shoulder areas of loess slopes and extend to a depth of several meters. Under natural conditions, loess’ static lateral pressure coefficient is low and the loess mass within a 2 m horizontal depth from the slope surface approximates an unconfined compression stress state. In this work, we sought to further examine this unconfined compression state using acoustic emission monitoring and in situ computed tomography scans to investigate the mechanical behavior of Malan loess. Results indicated that Malan loess failed under compression-induced tension in unconfined compression condition. It exhibited the brittle failure with an abrupt release of elastic energy. The failure plane was at large angles and occurred nearly along the loading axis. This result coincided well with the vertiloess structure, which is characterized by vertically aligned strong units and weak segments. The above failure mode supports the formation of vertical cracks in the loess strata and consequently the toppling and crack sliding slope failures, as well as the formation of loess walls and columns.
Experimental investigation of vibration-induced shear resistance reduction in sheared granular soils
Authors: Xie Tao , Guo Peijun , Stolle Dieter 
Published: July 2022

To investigate the characteristics of vibration-induced shear resistance reduction (ViSRR) in granular soils, laboratory tests were performed using a modified triaxial apparatus. Monotonic loading and vibration with controlled frequency and acceleration amplitude were superimposed to soil specimens under drained conditions. Tests were conducted for dry and saturated specimens at relative densities of Dr = 35% and 70%. The tests revealed that superimposed vibration causes a reduction of shear resistance in addition to an additional volume change of the specimen. After the termination of vibration, the shear resistance was found to be recovered as the monotonic shearing continued. It was confirmed that the shear resistance reduction was not caused by vibration-induced variation of excess pore pressure in the specimen. For high-frequency vibration with frequency varying between 60 and 120 Hz, the relative shear resistance loss tended to increase linearly with the peak acceleration. Based on the test results, the concept of “vibro-critical state” is proposed to describe the ViSRR of granular soil subjected to monotonic shear and vibration simultaneously.
The effect of feed efficiency classification on visceral organ mass in finishing steers
Authors: Cunningham-Hollinger Hannah C. , Gray Zebadiah T.L. , Christensen Kelcey W. , Means Warrie J. , Lake Scott L. , Paisley Steve I. , Cammack Kristi M. , Meyer Allison M. 
Published: July 2022

Individual feed intake of crossbred beef steers (one contemporary group/year, 2 years) was recorded during finishing to investigate visceral organ mass in steers divergent for feed efficiency. Based on residual feed intake (RFI), the 20% most efficient (HE, n = 8/year) and 20% least efficient (LE; n = 8/year) steers with 12th rib fat ≥1.02 cm were slaughtered. High efficiency steers had less DM intake ( P < 0.001), greater G:F ( P < 0.001), and similar ADG and hot carcass weight (HCW). High efficiency steers tended to have less ( P ≤ 0.10) small intestinal mass (actual and relative to BW and HCW) in year 1. In year 2, HE steers tended to have greater ( P ≤ 0.10) large intestinal actual and relative masses. Low efficiency steers tended to have greater ( P = 0.06) actual omasum mass and had greater ( P ≤ 0.03) relative omasum masses compared with HE. Stomach complex, total gastrointestinal tract, liver, and kidney masses tended to be greater ( P ≤ 0.10) relative to BW, and were greater ( P ≤ 0.05) relative to HCW, in LE. Data suggest that visceral organ mass, especially of the gastrointestinal tract, plays a role in overall metabolic efficiency of finishing steers.
Geochronology, geochemistry, and Hf isotopic compositions of the Early Devonian Heihaibei granite in the East Kunlun Orogen, Northwest China
Authors: Lu Haifeng , Pan Tong , Jiao He , Ding Qing-feng , Zheng Tao , Zhou Xuan , Wu Ruizhe 
Published: July 2022

The East Kunlun Orogen (EKO) is located in the western part of the Central Asian Orogenic Belt, and it records the Neoproterozoic–Early Devonian tectonic evolution involving the subduction and extinction of the Proto-Tethys Ocean. The Heihaibei granite is located in the South Kunlun belt within EKO. In this study, geochronology, geochemistry, and Hf isotope analysis of Heihaibei monzogranite and granodiorite were carried out. Their LA-ICP-MS zircon U-Pb results yielded ages of 414.1 ± 2.0 and 417.8 ± 2.0 Ma. The Heihaibei granite is peraluminous (A/CNK = 0.99–1.30), with high alkali contents (7.76–9.14 wt.%) and 10 000 Ga/Al (2.60–3.38), FeOT/MgO (27.6–49.5), and Y/Nb ratios (1.93–2.93), suggesting that the Heihaibei granite is an A2-type granite. The Heihaibei granite samples have zircon εHf(t) values ranging from −6.3 to −0.3, which suggests that the Early Devonian granite was derived from partial melting of Mesoproterozoic ( TDM2 = 1797–1415 Ma) crust. When considering data on contemporaneous granites, geochronological and geochemical data for the Heihaibei granite indicate that it was emplaced in a post-collisional extension environment following the closure of the Proto-Tethys Ocean. The Heihaibei granite was formed by extension of the southern subduction accretionary complex as part of the post-collisional setting during the closure of the Proto-Tethys Ocean.
Pelatihan Pembuatan Biobriket Ramah Lingkungan Berbahan Dasar Campuran Limbah Bonggol Jagung/Ampas Kopi/Serbuk Gergaji Kayu Kelompok Masyarakat Petani (GAPOKTAN) KM 12 Balikpapan Utara
Authors: Soemarsono Annisa Rahmita , Ernawati Lusi , Nafisah Azmia Rizka , Tarmidzi Fadhil Muhammad 
Published: July 2022

Kebutuhan energi masyarakat yang meningkat tiap tahun masih sangat bergantung kepada energi fosil. Untuk pemenuhan kebutuhan rumah tangga masih mengandalkan minyak tanah dan gas LPG. Salah satu cara mengurangi penggunaan energi fosil adalah dengan menggunakan limbah bonggol jagung hasil kelompok masyarakat petani jagung menjadi biobriket. Biobriket merupakan salah satu sumber energi terbarukan. Limbah bonggol jagung adalah limbah padat dari hasil pertanian dan industri. Limbah bonggol jagung memiliki kandungan selulosa, hemiselulosa, dan lignin. Kadar selulosa yang tinggi pada limbah bonggol jagung dapat dimanfaatkan sebagai bahan utama penyusun biobriket. Peningkatan kualitas biobriket berbanding lurus dengan peningkatan kadar selulosa. Selain selulosa, juga dibutuhkan bahan perekat untuk mengikat matriks biobriket. Tepung tapioka dipilih menjadi bahan perekat dalam kegiatan pengolahan biobriket ramah lingkungan. Biobriket dipastikan memiliki tingkat keefektifan yang baik untuk mengurangi penggunaan energi fosil dan memiliki nilai ekonomis yang tinggi bagi produsen dan konsumen di Kalimantan Timur. Kelompok masyarakat petani Balikpapan Utara adalah salah satu kelompok petani yang kurang memiliki wawasan terkait pemanfaatan limbah pertanian menjadi produk ramah lingkungan bernilai ekonomis dan berpotensi sebagai pengganti bahan bakar, seperti biobriket. Oleh karena itu, dilakukan sosialisasi dan pelatihan pembentukan biobriket menggunakan bahan dasar limbah pertanian terhadap kelompok petani tersebut. Dengan demikian, biobriket dari kombinasi limbah bonggol jagung/serbuk gergaji kayu/ampas kopi dengan perekat tepung tapioka diharapkan dapat mengatasi kebutuhan energi bagi masyarakat pada masa yang akan datang.
Prediction of Neurological Deterioration After Intracerebral Hemorrhage: The SIGNALS Score
Authors: He Quanwei , Guo Hongxiu , Bi Rentang , Chen Shaoli , Shen Jing , Long Chunnan , Li Man , Xia Yuanpeng , Zhang Lei , Sun Zhou , Chen Xiaolu , Wang Zhaowei , Gong Daokai , Xu Jingwen , Zhu Dondya , Wan Yan , Hu Bo 
Published: July 2022

Background
Intracerebral hemorrhage is the most disabling and lethal form of stroke. We aimed to develop a novel clinical score for neurological deterioration during hospitalization after intracerebral hemorrhage.

Methods and Results

We analyzed data from the CHERRY (Chinese Cerebral Hemorrhage: Mechanism and Intervention) study. Two‐thirds of eligible patients were randomly allocated into the training cohort (n=1027) and one‐third into the validation cohort (n=515). Multivariable logistic regression was used to identify factors associated with neurological deterioration (an increase in National Institutes of Health Stroke Scale of ≥4 or death) within 15 days after symptom onset. A prediction score was developed based on regression coefficients derived from the logistic model. The site, size, gender, National Institutes of Health Stroke Scale, age, leukocyte, sugar (SIGNALS) score was developed as a sum of individual points (0–8) based on site (1 point for infratentorial location), size (3 points for >20 mL of supratentorial hematoma volume or 2 points for >10 mL of infratentorial hematoma volume), sex (1 point for male sex), National Institutes of Health Stroke Scale score (1 point for >10), age (1 point for ≥70 years), white blood cell (1 point for>9.0×10
9
/L), and fasting blood glucose (1 point>7.0 mmol/L). The proportion of patients who suffered from neurological deterioration increased with higher SIGNALS score, showing good discrimination and good calibration in the training cohort (C statistic, 0.821; Hosmer‐Lemeshow test,
P
=0.687) and in the validation cohort (C statistic, 0.848; Hosmer‐Lemeshow test,
P
=0.592), respectively.

Conclusions
The SIGNALS score reliably predicts the risk of in‐hospital neurological deterioration of patients with intracerebral hemorrhage.
Polygenic Risk, Midlife Life's Simple 7, and Lifetime Risk of Stroke
Authors: Thomas Emy A. , Enduru Nitesh , Tin Adrienne , Boerwinkle Eric , Griswold Michael E. , Mosley Thomas H. , Gottesman Rebecca F. , Fornage Myriam 
Published: July 2022

Background
Recent genetic discoveries in stroke have unleashed the potential of using genetic information for risk prediction and health interventions aimed at disease prevention. We sought to estimate the lifetime risk of stroke (LTRS) by levels of genetic risk and to investigate whether optimal cardiovascular health can offset the negative impact of high genetic risk on lifetime risk of stroke.

Methods and Results
Study participants were 11 568 middle‐aged adults (56% women, 23% Black adults), who were free of stroke at baseline and were followed up for a median of 28 years. The remaining LTRS was estimated according to levels of genetic risk based on a validated stroke polygenic risk score, and to levels of cardiovascular health based on the American Heart Association Life's Simple 7 recommendations. At age 45, individuals with high, intermediate, and low polygenic risk score had a remaining LTRS of 23.2% (95% CI, 20.8%–25.5%), 13.8% (95% CI, 11.7%–15.8%), and 9.6% (95% CI, 7.3%–11.8%), respectively. Those with both a high genetic risk and an inadequate Life's Simple 7 experienced the highest LTRS: 24.8% (95% CI, 22.0%–27.6%). Across all polygenic risk score categories, those with an optimal Life's Simple 7 had a ≈30% to 43% lower LTRS than those with an inadequate Life's Simple 7. This corresponded to almost 6 additional years lived free of stroke.

Conclusions
The LTRS varies by levels of polygenic risk and cardiovascular health. Maintaining an optimal cardiovascular health can partially offset a high genetic risk, emphasizing the importance of modifiable risk factors and illustrating the potential of personalizing genetic risk information to motivate lifestyle changes for stroke prevention.
Women Who Know Ritual
Authors: Wang Hwa Yeong 
Published: July 2022

Abstract
Too often Confucian women’s voices and experiences are neglected as insignificant. This paper provides a wide and diverse set of examples of traditional Chinese and Korean women who knew and practiced Confucian ritual. Though representing only a small percentage of traditional women, these examples provide clear evidence and compelling arguments that support the following three conclusions. First, that the Confucian tradition did not deny women’s ability to know and perform rituals; second, that Confucian women read, learned, evaluated, decided, and contributed to re/create the conception and practice of ritual; and third, that this led at least some women and the men around them to recognize and admire not only their moral agency but also their ability to become sages.
Beyond Confucianism: Feminist Scholarship on Daoism and Buddhism
Authors: Dai Yuanfang 
Published: July 2022

Abstract
In this paper, I present and assess feminist philosophical thinking related to Daoism and Buddhism. I argue that despite the complexity, feminist scholarship on Daoism and Buddhism illustrates the diversity of feminist scholarship regarding Chinese traditions because it goes beyond the dominant Confucianism. I also argue that it exhibits a transcultural trend in which issues about gender intersect with Daoism and Buddhism. In addition, I suggest that Chinese philosophy should interact with Chinese feminism and gender studies in China to cultivate an explicit Chinese feminist philosophy.
Irigaray and Confucius: A Collaborative Approach to (Feminist) Agency
Authors: Amarantidou Dimitra , D’Ambrosio Paul J. 
Published: July 2022

Abstract
In this paper we take Luce Irigaray’s idea of fluid feminine subjectivity as productive for the project of rethinking agency in a collaborative feminist-Confucian context. We discuss how diffused agency in the Analects can be used alongside Irigaray’s work to critique contemporary notions of atomic agency. Our argument employs the notions of fluidity and agency in Irigaray and the Analects with concentrations on: 1) similarities between Irigaray’s “philosophy of breath” and Confucian ritual; 2) parallels between fluid feminine subjectivity and diffused agency; and 3) a shared concern for the ethical life. We thus see how Confucianism can contribute to contemporary feminist discourse.
詮釋與本體—論本體詮釋學
Authors: Pan (潘德榮) Derong 
Published: July 2022

摘 要
成中英從中西比較哲學的視角創造性地提出了本體詮釋學理論, 反思海德格爾與伽達默爾的本體論詮釋學, 揭示出其存在論中的價值缺失；並通過援引中國易學傳統中的道與本體發生, 以自本體與對本體的 “本體詮釋圓環” 使得認識論進路與本體論詮釋進路相結合, 實現了把價值維度和方法論融入了本體詮釋, 以推動當代詮釋學發展。本體詮釋學的創立, 開啟了 “本” 與 “體” 之間循環的本體綜合, 通過本體規範方法與通過方法條理化本體, 使得理解、 價值和方法構成一個有機的圓融整體, 指向了一種德福一致的本體展開, 即德 行詮釋學的發展可能。
The Phantom Senex
Authors: Cowan Robert 
Published: July 2022

Abstract
The character designated by the manuscripts as Senex, who accompanies Andromache and Astyanax in act three of Seneca’s Troades, is problematic in many ways. He is not identified or acknowledged by any other character; his entrance and exit are unannounced; his presence onstage in the first half of the act requires that Astyanax’s two words of dialogue be delivered by a fourth actor or through ventriloquism; his very existence conflicts with the obvious interpretation of at least two sections of Andromache’s dialogue. All of these anomalies can be removed if there is in fact no Senex and the dialogue attributed to him by the manuscripts is spoken by the Chorus leader. This level of involvement in the action by the Chorus would itself be unusual in Senecan tragedy, but it does have parallels and would also fit with the exceptional treatment of the Chorus throughout Troades.
Beyond Violence: Understanding Social Cohesion and Peace Attributes on the Tanzania-Mozambique Border
Authors: Walwa William John 
Published: July 2022

Abstract
The analysis of cross-border issues on the Tanzania-Mozambique border is increasingly influenced and reduced to the current war in northern Mozambique. In effect, positive images, such as social cohesion that historically tied together the communities from the two countries, and which could be tapped to find solutions, received little attention. As such, this paper analyzed the social cohesion attributes of communities on the Tanzania-Mozambique border. It uncovered that cross-border farming, fishing and religious activities have been key sources of social cohesion – helping to reinforce community resilience, livelihoods and peace. However, recent attacks from an extremist group based in Mozambique have undermined these social cohesion attributes and increased risks and vulnerabilities of communities to conflicts and violence. Among other things, achieving sustainable solutions to the ongoing war will demand investing in the protection and promotion of already existing social cohesion attributes that contribute to address socio-economic challenges of border communities.
How can shared reading be used to develop community connectivity in the contemporary church?
Authors: Baverstock Alison , Steinitz Jackie , Cowie Andrew 
Published: July 2022

Abstract
This paper reports on a project to use, within church communities, previous experience in universities and schools of shared reading for the purposes of outreach, widening participation, and community inclusion. It outlines and explores the experience of selecting a book, and its subsequent discussion among a group of parishioners, to promote a sense of connectedness and belonging. The outcomes have implications for creating and strengthening links within existing church communities, reaching out to those who live locally but are not regular church attenders, and drawing others towards the church from the wider, not necessarily geographically local, community.