bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural, Dielectric, Electrical, and Thermal Properties of the Ce-Doped Ba2TiMoO6 Double Perovskite
Authors: Ghrib Taher 
Published: September 2022

Abstract
Ce-doped Ba2TiMoO6 with different Ce percentage was synthesized by solid state reaction and investigated. Electrical and thermal properties were examined by using X-ray powder diffraction (XRD), scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), and photothermal deflection (PTD) technique. The electrical investigation shows that the increase of Ce doping percentage favors the electrical confinement which leads to a decrease in the electrical capacitance from 2.6 nF to 1.6 nF, an increase in the grain boundaries resistance from 5.88 × 107 to 6.50 × 108 Ω, a decrease in the current density from 60 nA to 3 nA, and a decrease of thermal conductivity from 1.8 W m−1 K−1 to 0.12 W m−1 K−1. These results introduce the Ce-doped Ba2TiMoO6 perovskite as a potential candidate for a new generation of thermal barrier coatings (TBCs).
Physical Activity and Eating Behavior Inequalities Mediating the Effects of Socioeconomic Status and Sex on Adolescent Quality of Life: Insights of the PRALIMAP Trial
Authors: Manneville Florian , Briançon Serge , Legrand Karine , Langlois Johanne , Lecomte Edith , Omorou Abdou Y. , Guillemin Francis 
Published: September 2022

Background: This study aimed to quantify the 2-year mediating effects of physical activity (PA) and eating behavior (EB) on socioeconomic and sex inequalities in quality of life (QoL) among French adolescents. Methods: Adolescents from a 2-year school-based trial were included. PA and EB were assessed at baseline, 1 year, and 2 years using the International Physical Activity Questionnaire and an eating habits questionnaire, respectively. QoL was measured at 2 years using the Duke Health Profile questionnaire. The mediating effect of adherence to PA and EB guidelines in the associations between socioeconomic status or sex and QoL was analyzed with a counterfactual method. Results: Among the 3562 included adolescents (mean age, 15.2 [0.6] y), being a boy and having a high socioeconomic status was associated with high QoL. Differences in QoL by socioeconomic status were mediated by adherence to guidelines for PA (up to 10.2%) and EB (up to 8.8%), and differences in QoL by sex were predominantly mediated by adherence to guidelines for PA (up to 163.8%). Conclusions: Policies, programs, and interventions designed to reduce socioeconomic and sex inequalities in QoL among adolescents could use PA and EB as leverage.
Increasing anti-S antibody testing: a quality improvement initiative with evolving COVID-19 guidelines
Authors: Alam Ali M , Lester Rebecca , Hoyle Marie-Claire , Fletcher Tom E , Hine Paul 
Published: September 2022

BackgroundCOVID-19 management guidelines are constantly evolving, making them difficult to implement practically.Ronaprevewas a neutralising monoclonal antibody introduced into UK COVID-19 guidelines in 2021. It reduces mortality in seronegative patients infected with non-omicron variants. Antibody testing on admission is therefore vital in ensuring patients could be considered forRonapreveas inpatients.Local problemWe found that on our COVID-19 ward, 31.4% of patients were not having anti-S tests despite fulfilling the other criteria to be eligible forRonapreve. This was identified as an important target to improve; by not requesting anti-S tests, we were forgoing the opportunity to use an intervention that could improve outcomes.MethodsWe analysed patient records for patients with COVID-19 admitted to our ward over 4 months to observe if awareness of the need to request anti-S increased through conducting plan–do–study–act (PDSA) cycles.InterventionsOur first intervention was an multidisciplinary team (MDT) discussion at our departmental audit meeting highlighting our baseline findings and the importance of anti-S requesting. Our second intervention was to hang printed posters in both the doctors’ room and the ward as a visual reminder to staff. Our final intervention was trust-wide communications of updated local COVID-19 guidance that included instructions for anti-S requesting on admission.ResultsOur baseline data showed that only 68.6% of patients with symptomatic COVID-19 were having anti-S antibody tests requested. This increased to 95.0% following our three interventions. There was also a reduction in the amount of anti-S requests being ‘added on’, from 57.1% to 15.8%.ConclusionsCOVID-19 guidelines are constantly evolving and require interventions that can be quickly and easily implemented to improve adherence. Sustained reminders through different approaches allowed a continued increase in requesting. This agrees with research that suggests a mixture of educational sessions and visual reminders of guidelines increase their application in clinical practice.
In situ delivery of nanoparticles formulated with micron-sized crystals protects from murine melanoma
Authors: Mohsen Mona O , Heath Matthew , Kramer Matthias F , Velazquez Thalia Carreno , Bullimore Alan , Skinner Murray A , Speiser Daniel E , Bachmann Martin F 
Published: September 2022

IntroductionIntratumoral injections of novel therapeutics can activate tumor antigen-specific T cells for locoregional tumor control and may even induce durable systemic protection (against distant metastases) via recirculating T cells. Here we explored the possibility of a universal immunotherapy that promotes T-cell responses in situ and beyond, upon intratumoral injection of nanoparticles formulated with micron-sized crystals.MethodsCucumber mosaic virus-like particles containing a tetanus toxin peptide (CuMVTT) were formulated with microcrystalline tyrosine (MCT) adjuvant and injected directly in B16F10 melanoma tumors. To further enhance immunogenicity, we loaded the nanoparticles with a TLR7/8 ligand and incorporated a universal tetanus toxin T-helper cell peptide. We assessed therapeutic efficacy and induction of local and systemic immune responses, including RNA sequencing, providing broad insight into the tumor microenvironment and correlates of protection.ResultsMCT crystals were successfully decorated with CuMVTTnanoparticles. This ‘immune-enhancer’ formed immunogenic depots in injected tumors, enhanced polyfunctional CD8+and CD4+T cells, and inhibited B16F10 tumor growth locally and systemically. Local inflammation and immune responses were associated with upregulation of genes involved in complement activation and collagen formation.ConclusionsOur new immune-enhancer turned immunologically cold tumors into hot ones and inhibited local and distant tumor growth. This type of immunotherapy does not require the identification of (patient–individual) relevant tumor antigens. It is well tolerated, non-infectious, and affordable, and can readily be upscaled for future clinical testing and broad application in melanoma and likely other solid tumors.
Sex differences of vascular brain lesions in patients with atrial fibrillation
Authors: Ceylan Selinda , Aeschbacher Stefanie , Altermatt Anna , Sinnecker Tim , Rodondi Nicolas , Blum Manuel , Coslovsky Michael , Evers-Dörpfeld Simone , Niederberger Sacha , Conen David , Osswald Stefan , Kühne Michael , Düring Marco , Wuerfel Jens , Bonati Leo 
Published: September 2022

ObjectiveTo examine sex differences in prevalence, volume and distribution of vascular brain lesions on MRI among patients with atrial fibrillation (AF).MethodsIn this cross-sectional analysis, we included 1743 patients with AF (27% women) from the multicentre Swiss Atrial Fibrillation study (SWISS-AF) with available baseline brain MRI. We compared presence and total volume of large non-cortical or cortical infarcts (LNCCIs), small non-cortical infarcts, microbleeds (MB) and white matter hyperintensities (WMH, Fazekas score ≥2 for moderate or severe degree) between men and women with multivariable logistic regression. We generated voxel-based probability maps to assess the anatomical distribution of lesions.ResultsWe found no strong evidence for an association of female sex with the prevalence of all ischaemic infarcts (LNCCI and SNCI combined; adjusted OR 0.86, 95% CI 0.67 to 1.09, p=0.22), MB (adjusted OR 0.91, 95% CI 0.68 to 1.21, p=0.52) and moderate or severe WMH (adjusted OR 1.15, 95% CI 0.90 to 1.48, p=0.27). However, total WMH volume was 17% larger among women than men (multivariable adjusted multiplicative effect 1.17, 95% CI 1.01 to 1.35; p=0.04). Lesion probability maps showed a right hemispheric preponderance of ischaemic infarcts in both men and women, while WMH were distributed symmetrically.ConclusionWomen had higher white matter disease burden than men, while volume and prevalence of other lesions did not differ. Our findings highlight the importance of controlling risk factors for cerebral small vessel disease in patients with AF, especially among women.
Projecting the impact of implementation of WHO MPOWER measures on smoking prevalence and mortality in Japan
Authors: Yang Su Lan , Togawa Kayo , Gilmour Stuart , Leon Maria E , Soerjomataram Isabelle , Katanoda Kota 
Published: September 2022

ObjectiveThis study aimed to quantify the long-term impact of implementing the WHO Framework Convention on Tobacco Control (FCTC) compliant tobacco control measures, MPOWER, on smoking prevalence and mortality in men and women aged ≥20 years in Japan.DesignA Stock-and-Flow simulation model was used to project smoking prevalence and mortality from 2018 to 2050 under eight different scenarios: (1) maintaining the 2018 status quo, (2) implementation of smoke-free policies, (3) tobacco use cessation programmes, (4–5) health warning about the dangers of tobacco (labels, mass media), (6) enforcement of tobacco advertising bans or (7) tobacco taxation at the highest recommended level and (8) all these interventions combined.ResultsUnder the status quo, the smoking prevalence in Japan will decrease from 29.6% to 15.5% in men and 8.3% to 4.7% in women by 2050. Full implementation of MPOWER will accelerate this trend, dropping the prevalence to 10.6% in men and 3.2% in women, and save nearly a quarter million deaths by 2050. This reduction implies that Japan will only attain the current national target of 12% overall smoking prevalence in 2033, 8 years earlier than it would with the status quo (in 2041), a significant delay from the national government’s 2022 deadline.ConclusionsTo bring forward the elimination of tobacco smoking and substantially reduce smoking-related deaths, the government of Japan should fulfil its commitment to the FCTC and adopt stringent tobacco control measures delineated by MPOWER and beyond.
First upper limits on neutrino electromagnetic properties from the CONUS experiment
Authors: Bonet H. , Bonhomme A. , Buck C. , Fülber K. , Hakenmüller J. , Hempfling J. , Heusser G. , Hugle T. , Lindner M. , Maneschg W. , Rink T. , Strecker H. , Wink R. ,   CONUS Collaboration
Published: September 2022

AbstractWe report first constraints on electromagnetic properties of neutrinos from neutrino-electron scattering using data obtained from the CONUS germanium detectors, i.e. an upper limit on the effective neutrino magnetic moment and an upper limit on the effective neutrino millicharge. The electron antineutrinos are emitted from the 3.9 $$\hbox {GW}_\mathrm {th}$$

GW
th

reactor core of the Brokdorf Nuclear Power Plant in Germany. The CONUS low-background detectors are positioned at a distance of 17.1 m from the reactor core center. The analyzed data set includes 689.1 kg d collected during reactor ON periods and 131.0 kg d collected during reactor OFF periods in the energy range of . With the current statistics, we are able to determine an upper limit on the effective neutrino magnetic moment of $$\mu _\nu < 7.5\cdot 10^{-11}\,\mu _B$$

μ
ν

<
7.5
·

10

-
11

μ
B

at 90% confidence level. No neutrino signal in this channel or in the CE$$\nu $$
ν
NS channel has been observed at a nuclear power plant so far. From this first magnetic moment limit we can derive an upper bound on the neutrino millicharge of $$\vert {q}_{\nu }\vert < 3.3\cdot 10^{-12}\,e_0$$

|

q
ν

|
<
3.3
·

10

-
12

e
0

.
Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients
Authors: Himbert Caroline , Warby Christy A. , Gigic Biljana , Ose Jennifer , Lin Tengda , Viskochil Richard , Peoples Anita R. , Ashworth Anjelica , Schrotz-King Petra , Scaife Courtney L. , Cohan Jessica N. , Jedrzkiewicz Jolanta , Schirmacher Peter , Grady William M. , Cohen Stacey A. , Krane Mukta , Figueiredo Jane C. , Toriola Adetunji T. , Siegel Erin M. , Shibata David , Round June L. , Huang Lyen C. , Li Christopher I. , Schneider Martin , Ulrich Alexis , Hardikar Sheetal , Ulrich Cornelia M. 
Published: September 2022

Abstract

Background:
Physical activity and obesity are well-established factors of colorectal cancer risk and prognosis. Here, we investigate associations of individual and combined physical activity and body mass index (BMI) groups with proinflammatory biomarkers in colorectal cancer patients.

Methods:
Self-reported physical activity levels were classified as “active” (≥8.75 MET-hours/week) versus “inactive” (&lt;8.75 MET-hours/week) in n = 579 stage I–IV colorectal cancer patients enrolled in the ColoCare Study. BMI [normal weight (≥18.5–&lt;25 kg/m2), overweight (≥25–&lt;30 kg/m2), and obese (≥30 kg/m2)] was abstracted from medical records. Patients were classified into four combinations of physical activity levels and BMI. Biomarkers [C-reactive protein (CRP), SAA, IL6, IL8, and TNFα] in presurgery serum samples were measured using the Mesoscale Discovery Platform. Regression models were used to compute relative percent differences in biomarker levels by physical activity and BMI groups.

Results:
“Inactive” patients had non-statistically significant higher IL6 levels compared with “active” patients (+36%, P = 0.10). “Obese” patients had 88% and 17% higher CRP and TNFα levels compared with “normal weight” patients (P = 0.03 and 0.02, respectively). Highest CRP levels were observed among “overweight or obese/inactive” compared with “normal weight/active” patients (P = 0.03).

Conclusions:
We provide evidence of associations between individual and combined physical activity and BMI groups with proinflammatory biomarkers. Although BMI was identified as the key driver of inflammation, biomarker levels were higher among “inactive” patients across BMI groups.

Impact:
This is the largest study in colorectal cancer patients investigating associations of energy balance components with inflammatory biomarkers. Our results suggest that physical activity may reduce obesity-induced inflammation in colorectal cancer patients and support the design of randomized controlled trials testing this hypothesis.
Low-Level Cloud Budgets across Sea Ice Edges
Authors: Zheng Youtong , Ming Yi 
Published: September 2022

Abstract
Interpreting behaviors of low-level clouds (LLCs) in a climate model is often not straightforward. This is particularly so over polar oceans where frozen and unfrozen surfaces coexist, with horizontal winds streaming across them, shaping LLCs. To add clarity to this interpretation issue, we conduct budget analyses of LLCs using a global atmosphere model with a fully prognostic cloud scheme. After substantiating the model’s skill in reproducing observed LLCs, we use the modeled budgets of cloud fraction and water content to elucidate physics governing changes of LLCs across sea ice edges. Contrasting LLC regimes between open water and sea ice are found. LLCs over sea ice are primarily maintained by large-scale condensation: intermittent intrusions of maritime humid air and surface radiative cooling jointly sustain high relative humidity near the surface, forming extensive but tenuous stratus. This contrasts with the LLCs over open water where the convection and boundary layer condensation sustain the LLCs on top of deeper boundary layers. Such contrasting LLC regimes are influenced by the direction of horizontal advection. During on-ice flow, large-scale condensation dominates the regions, both open water and sea ice regions, forming clouds throughout the lowest several kilometers of the troposphere. During off-ice flow, as cold air masses travel over the open water, the cloud layer lifts and becomes denser, driven by increased surface fluxes that generate LLCs through boundary layer condensation and convective detrainment. These results hold in all seasons except summer when the atmosphere–surface decoupling substantially reduces the footprints of surface type changes.
Long-term prognosis of curative endoscopic submucosal dissection for early colorectal cancer according to submucosal invasion: a multicenter cohort study
Authors: Shin Jongbeom , Kim Eun Ran , Jang Hyun Joo , Baek Dong Hoon , Yang Dong-Hoon , Lee Bo-In , Cho Kwang Bum , Cho Jin Woong , Jung Sung-Ae , Hong Su Jin , Ko Bong Min ,   The Research Group for Endoscopic Submucosal Dissection in Korean Society of Gastrointestinal Endoscopy, Jeon Jung-Won , Ko Weon Jin , Kim Sun Moon , Kim Young Dae , Gyoo Kim Chan , Baik Gwang Ho , Yoo In Kyung , Nyeong Lee Kang , Lee Si Hyung , Lim Chul-Hyun , Jeon Seong Woo 
Published: September 2022

Abstract
Background
Endoscopic submucosal dissection (ESD) can provide a high en bloc resection rate and has been widely applied as curative treatment for early colorectal cancer (ECC). However, surgical treatment is occasionally required, and reports on the long-term prognosis of ESD are insufficient. This study aimed to investigate the long-term outcomes of ECC removal by ESD, including local recurrence and metastasis.

Methods
This multicenter study was conducted retrospectively on 450 consecutive patients with ECC who were treated with ESD between November 2003 and December 2013. Clinical, pathological, and endoscopic data were collected to determine tumor depth, resection margin, lymphovascular invasion, and recurrence.

Results
The median follow-up period was 53.8 (12–138 months). The en bloc resection rate was 85.3% (384) and in intramucosal cancer being 84.1% and in superficial submucosal invasion (SM1) cancer being 89.8% (p = 0.158). The curative resection rate was 76.0% (n = 342), and there was no statistical difference between the two groups (77.3% vs. 71.4%, p = 0.231). The overall recurrence free survival rate (RFS) was 98.7% (444/450). In patients with curative resection, there was no statistically significant difference in RFS according to invasion depth (intramucosal: 99.3% vs. SM1: 97.1%, p = 0.248).

Conclusions
Patients with curatively resected ECC treated with ESD showed favorable long-term outcomes. Curatively resected SM1 cancer has a RFS similar to that of intramucosal cancer.
Analysis of patient’s X-ray exposure in hepatic chemosaturation procedures: a single center experience
Authors: Ebel Sebastian , Reinhardt Martin , Beeskow Anne Bettina , Teske Felix , Struck Manuel Florian , Veelken Rhea , van Boemmel Florian , Berg Thomas , Moche Michael , Gutberlet Matthias , Gößmann Holger , Denecke Timm 
Published: September 2022

Abstract
Background
Hepatic chemosaturation is a technique in which a high dose of the chemotherapeutic agent melphalan is administered directly into the liver while limiting systemic side effects. We reviewed our institutional experience regarding patient’s X-ray exposure caused by the procedure.

Methods
Fifty-five procedures, performed between 2016 and 2020 in 18 patients by three interventional radiologists (radiologist), were analyzed regarding the patient’s exposure to radiation. Dose-area-product (DAP) and fluoroscopy time (FT) were correlated with the experience of the radiologist and whether the preprocedural evaluation (CS-EVA) and the procedure were performed by the same radiologist. Additionally, the impact of previous liver surgery on DAP/FT was analyzed.

Results
Experienced radiologist require less DAP/FT (50 ± 18 Gy*cm2/13.2 ± 3.84 min vs. 69 ± 20 Gy*cm2/15.77 ± 7.82 min; p < 0.001). Chemosaturations performed by the same radiologist who performed CS-EVA required less DAP/FT (41 ± 12 Gy*cm2/11.46 ± 4.41 min vs. 62 ± 11 Gy*cm2/15.55 ± 7.91 min; p < 0.001). Chemosaturations in patients with prior liver surgery with involvement of the inferior cava vein required significantly higher DAP/FT (153 ± 27 Gy*cm2/25.43 ± 4.57 min vs. 56 ± 25 Gy*cm2/14.44 ± 7.55 min; p < 0.001).

Conclusion
There is a significant learning curve regarding the procedure of hepatic chemosaturation. Due to dose reduction the evaluation and chemosaturation therapy should be performed by the same radiologist. Procedures in patients with previous liver surgery require higher DAP/FT.
Immune checkpoint inhibitor (ICI) genes and aging in malignant melanoma patients: a clinicogenomic TCGA study
Authors: Safi Mohammed , Jin Chenxing , Aldanakh Abdullah , Feng Ping , Qin Henan , Alradhi Mohammed , Zhang Lizhi , Zhang Junying , Adlat Salah , Zhao Yi , Liu Jiwei 
Published: September 2022

Abstract
Background
Cancer diagnoses and deaths among the elderly (65 +) are expected to increase significantly over the next decade. Immune checkpoint inhibitors specifically target ICI genes and enhance immune system function. However, poor outcomes may be associated with aging.

Methods
We downloaded the Genomic Data Commons from the Cancer Genome Atlas (TCGA) and collected gene expression data from malignant melanoma (MM) tissues, the third level as the primary site. The CKTTD ICI genes database were applied and validated using the GEO database and lab experiments.

Results
In 414 patients, 13 ICI genes were obtained as risk gene signature by univariate and multivariate Cox hazard models and were associated with poor survival in the older group. At 1, 3, and 5 years (79%, 76%, and 76%, respectively), we investigate TNFRFS4 gene and age prediction using novel nomogram-associated aging (HR = 1.79, P 0.001, CI = 1.32–2.45) with higher sensitivity testing.TNFRSF4 gene expression was significantly high in younger (15 years interval) MM patients (P < 0.001). By correlation analysis, a significant negative association was determined (P < 0.001). The validation of gene correlation from GEO (GSE59455) and (GSE22153) was obtained as external validation. We tested the TNFRSF4 protein levels by IHC in 14 melanoma tissue samples. TNFRSF4 expression was observed to be lower expressed in the older of melanoma tissues, and higher in the younger age group (P = 0.02). Besides the connectivity of ICI gene proteins, the biological processes of cell aging, aging, and the immune system were found to be highly related.

Conclusions
Along with the risk score evaluation, the ICI gene (TNFRSF4) was identified as a tumor suppressor gene related to inequalities in age survival and associated with immune cell infiltrations. The aging responses of melanoma patients and related gene expression need further investigation in order to identify potential therapeutic targets.