bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gaia white dwarfs within 40 pc – III. Spectroscopic observations of new candidates in the Southern hemisphere
Authors: O’Brien Mairi W , Tremblay P-E , Gentile Fusillo N P , Hollands M A , Gänsicke B T , Koester D , Pelisoli I , Cukanovaite E , Cunningham T , Doyle A E , Elms A , Farihi J , Hermes J J , Holberg J , Jordan S , Klein B L , Kleinman S J , Manser C J , De Martino D , Marsh T R , McCleery J , Melis C , Nitta A , Parsons S G , Raddi R , Rebassa-Mansergas A , Schreiber M R , Silvotti R , Steeghs D , Toloza O , Toonen S , Torres S , Weinberger A J , Zuckerman B 
Published: November 2022

Abstract
We present a spectroscopic survey of 248 white dwarf candidates within 40 pc of the Sun; of these 244 are in the Southern hemisphere. Observations were performed mostly with the Very Large Telescope (X-Shooter) and Southern Astrophysical Research Telescope. Almost all candidates were selected from Gaia Data Release 3 (DR3). We find a total of 246 confirmed white dwarfs, 209 of which had no previously published spectra, and two main-sequence star contaminants. Of these, 100 white dwarfs display hydrogen Balmer lines, 69 have featureless spectra, and two show only neutral helium lines. Additionally, 14 white dwarfs display traces of carbon, while 37 have traces of other elements that are heavier than helium. We observe 35 magnetic white dwarfs through the detection of Zeeman splitting of their hydrogen Balmer or metal spectral lines. High spectroscopic completeness (&gt; 97 per cent) has now been reached, such that we have 1058 confirmed Gaia DR3 white dwarfs out of 1083 candidates within 40 pc of the Sun at all declinations.
Astrometric detection of binary asteroids
Authors: Segev Noam , Ofek Eran O , Polishook David 
Published: November 2022

ABSTRACT
Binary asteroids probe thermal-radiation effects on the main-belt asteroids’ evolution. We discuss the possibility of detecting binary minor planet systems by the astrometric wobble of the centre of light around the centre of mass. This method enables the exploration of the phase-space of binary asteroids, which is difficult to explore using common detection techniques. We describe a forward model that projects the centre-of-light position with respect to the centre of mass, as it is seen by the observer. We study the performance of this method using simulated Gaia-like data. We apply the astrometric method to a subset of the Gaia DR2 Solar system catalogue and find no significant evidence of binary asteroids. This is likely because the Gaia DR2 removed astrometric outliers, which in our case may be due to astrophysical signals. Applying this method to binary asteroid (4337) Arecibo, for which Gaia DR3 reported a possible astrometric signal with a period of P = 32.85 ± 0.38 h, reveals a possible 2.2σ solution with a period of 16.26 h (about half the reported period). We find a small, marginally significant, excess of astrometric noise in the known binary asteroid population from Pravec et al. relative to the entire asteroid population in the Gaia DR2 Solar system catalogue. We also discuss some caveats like precession and asteroid rotation.
Effect of honey on cardiometabolic risk factors: a systematic review and meta-analysis
Authors: Ahmed Amna , Tul-Noor Zujaja , Lee Danielle , Bajwah Shamaila , Ahmed Zara , Zafar Shanza , Syeda Maliha , Jamil Fakeha , Qureshi Faizaan , Zia Fatima , Baig Rumsha , Ahmed Saniya , Tayyiba Mobushra , Ahmad Suleman , Ramdath Dan , Tsao Rong , Cui Steve , Kendall Cyril W C , de Souza Russell J , Khan Tauseef A , Sievenpiper John L 
Published: November 2022

Abstract

Context
Excess calories from free sugars are implicated in the epidemics of obesity and type 2 diabetes. Honey is a free sugar but is generally regarded as healthy.

Objective
The effect of honey on cardiometabolic risk factors was assessed via a systematic review and meta-analysis of controlled trials using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach.

Data Sources
MEDLINE, Embase, and the Cochrane Library databases were searched up to January 4, 2021, for controlled trials ≥1 week in duration that assessed the effect of oral honey intake on adiposity, glycemic control, lipids, blood pressure, uric acid, inflammatory markers, and markers of nonalcoholic fatty liver disease.

Data Extraction
Independent reviewers extracted data and assessed risk of bias. Data were pooled using the inverse variance method and expressed as mean differences (MDs) with 95%CIs. Certainty of evidence was assessed using GRADE.

Data Analysis
A total of 18 controlled trials (33 trial comparisons, N = 1105 participants) were included. Overall, honey reduced fasting glucose (MD = −0.20 mmol/L, 95%CI, −0.37 to −0.04 mmol/L; low certainty of evidence), total cholesterol (MD = −0.18 mmol/L, 95%CI, −0.33 to −0.04 mmol/L; low certainty), low-density lipoprotein cholesterol (MD = −0.16 mmol/L, 95%CI, −0.30 to −0.02 mmol/L; low certainty), fasting triglycerides (MD = −0.13 mmol/L, 95%CI, −0.20 to −0.07 mmol/L; low certainty), and alanine aminotransferase (MD = −9.75 U/L, 95%CI, −18.29 to −1.21 U/L; low certainty) and increased high-density lipoprotein cholesterol (MD = 0.07 mmol/L, 95%CI, 0.04–0.10 mmol/L; high certainty). There were significant subgroup differences by floral source and by honey processing, with robinia honey, clover honey, and raw honey showing beneficial effects on fasting glucose and total cholesterol.

Conclusion
Honey, especially robinia, clover, and unprocessed raw honey, may improve glycemic control and lipid levels when consumed within a healthy dietary pattern. More studies focusing on the floral source and the processing of honey are required to increase certainty of the evidence.

Systematic Review Registration
PROSPERO registration number CRD42015023580.
Effect of strobe lights on catches and length distributions of euphausiids collected by Bongo nets
Authors: Gislason Astthor , Petursdottir Hildur , Reynisson Pall 
Published: November 2022

Abstract
Euphausiids are difficult to catch quantitatively with most net sampling systems due to avoidance of the nets. Previous studies have shown that bright lights may reduce euphausiid net avoidance from relatively large net sampling systems. This study describes experiments where strobe lights were mounted on the smaller Bongo net frame, and net avoidance evaluated by repeated towing through layers of euphausiids, as evidenced from acoustic backscattering data, with the strobe lights either on or off. The study was conducted both in fjord and offshore environments. The results show that the use of strobe lights significantly increases the catches of Thysanoessa raschii, T. inermis and Meganyctiphanes norvegica, and that the increase is mainly due to increased catches of the older components of the populations, whereas juveniles of the spring generations are relatively unaffected. The results for T. longicaudata are less conclusive although they indicate that the catches of this species are also positively affected by the strobe lights. The results lend support to the hypothesis that the use of the strobe lights increases catches by reducing net avoidance behavior of the euphausiids rather than by attracting them, and the catches therefore better representing the composition of the stock than if the lights were not used.
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria sets for three types of antineutrophilic cytoplasmic antibody-associated vasculitis
Authors: Yazici Hasan , Tascilar Koray , Yazici Yusuf 
Published: November 2022

Purpose of review
A critique of the recently published classification criteria for three main types of antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis.

Recent findings
An ACR and EULAR joint task force recently published classification criteria for three main types of ANCA-associated vasculitis. The criteria were based on patient histories and findings in nearly 7000 patients from 136 sites in 32 countries. As such the study represented hitherto the most intensive attempt to prepare classification criteria vasculitis. We propose, this truly intensive effort was, unfortunately, unsuccessful. There were two main mishaps. The first one was that the proposed criteria were not validated in an independent cohort. This is curious in that the sponsors, ACR and EULAR, require such independent cohorts for validation. The second mishap is that the concept that disease classification criteria need to be 100% sensitive and specific for a diagnosis is unrealistic. Moreover, all-purpose disease classification criteria are not respectful to scientific research and to the probabilistic nature of the art and the science of medicine.

Summary
The new ACR/EULAR ANCA-associated vasculitis guidelines have not been validated in independent cohorts. We propose replacing the term disease criteria with disease guidelines.
Construct Validity and Internal Consistency of the Physical Therapist Student Evaluation of Clinical Experience and Clinical Instruction
Authors: Gallivan Sean 
Published: November 2022

Introduction.
The purpose of this research was to assess the construct validity and internal consistency of the Physical Therapist Student Evaluation of Clinical Experience and Clinical Instruction Section II: Physical Therapist Student Evaluation of Clinical Instruction (PTSE).

Review of the Literature.
Physical therapy lacks a psychometrically sound student assessment of the performance of clinical instructor (CI), providing a basis for assessing the PTSE's internal consistency and construct validity.

Subjects.
A nonprobability convenience sample of 5,077 students from 29 physical therapist education programs (PTEPs) completed 6,851 PTSEs using a third-party clinical education management platform.

Methods.
To assess the construct validity of the PTSE, the researcher conducted exploratory factor analysis with principal axis factor extraction and promax oblique rotation on 3 PTSE data subsets. The researcher conducted internal consistency analyses on the 21-item PTSE and on each factor identified in the factor analyses.

Results.
For each PTSE subset, factor analysis identified one factor of 17 items, CI Effectiveness, which accounted for 48.5%, 54.1%, and 53.8% of the variance of the 3 data subsets, respectively. Factor analysis did not identify a factor solution that included all 21 Likert scale–rated items of Section 2 of the PTSE. Resultant Cronbach's alpha values met minimum levels of acceptable internal consistency while exceeding the 0.90 level that raises the concern of item redundancy.

Discussion and Conclusion.
Factor analysis results find plausible explanations for their degree of alignment with assessment tool item writing construction and scaling standards, although a one-factor PTSE is inconsistent with historical and prevailing multiple constructs of CI effectiveness. Individual factor and all-item internal consistency results raise concerns regarding the number and the redundancy of the questions. Factor analysis and internal consistency analyses of PTSEs completed by students from a nonprobability convenience sample of PTEPs suggest that PTEPs need a more psychometrically sound tool to assess CI performance.
Physical Therapy Education Through the Lens of the Master Adaptive Learner 24th Pauline Cerasoli Lecture
Authors: Jensen Gail M. 
Published: November 2022

Background and Purpose.
The Dr. Pauline Cerasoli Lecture is both an honor and an opportunity to learn from the past and look to the future of physical therapy education. This 24th Cerasoli lecture does just that in taking a reflective look at the question—What would excellence and innovation look like in physical therapy education if we were looking outward to what society needs from us?

Position and Rationale.
While the concepts associated with the master adaptive learner (MAL) have been applied primarily at the level of individual learners, the model provides a useful framework for this reflective look at physical therapy education. Grounded in the robust concepts of learning sciences and adaptive expertise, application of this model to physical therapy education is a lens for identifying our greatest challenges and envisioning drivers for transformative change.

Discussion and Conclusion.
The question of what could or should we be doing in physical therapy education to meet societal needs is used in the reflective analysis of three major areas: 1) Reimagining the role of curriculum, 2) Learning for a lifetime of learning, and 3) Education research: needed and wanted. Together, analysis of these three areas identify opportunities for all educators (clinical and academic) to be provocative (disruptive), innovative, and adaptive!
Clinical and prognostic features of CCI/PICS patients: A prospective observational clinical study
Authors: Zhou Qingqing , Qian Hebu , Yang Aixiang , Lu Jian , Liu Jun 
Published: November 2022

Abstract

Objective
To investigate and compare the clinical features and prognosis of chronic critical illness (CCI)/ persistent inflammation immunosuppression and catabolism (PICS).

Methods
This is a prospective observational clinical study. During this study period, we collect ICU patients’ data from Suzhou Municipal Hospital and Suzhou Ninth People’s Hospital. All patients older than 18 years of age were included and according to the corresponding exclusion and diagnostic criteria, they were divided into four groups: PICS group, CCI group, CCI and PICS group (CCI + PICS), nor CCI and nor PICS group (NCCI+NPICS), collected and recorded age, sex, hospital time, hospital diagnosis, acute physiological and chronic health status score II (APACHEII), sequential organ failure detection score(SOFA), c-reactive protein (CRP), absolute value lymphocyte count (L), serum albumin (Alb), white cells count (WBC), absolute value neutrophils count (N), secondary infection and 28-day case fatality rate separately.

Results
A total of 687 patients were admitted to the ICU during the study period. The hospitalization time less than 14 days were excluded, and 168 patients were eventually included. There are 17 in the PICS group, 71 in the CCI group, 50 in the CCI + PICS group, and 30 in the NCCI+NPICS group. Baseline characteristics showed statistically significant differences in SOFA, length of hospital stay, 28-day mortality among four groups. Baseline main indicator, and multiple comparisons showed that the CCI + PICS group had longer hospital stay, worse prognosis and more adverse outcomes. Multivariate analysis showed that final age, CRP on day 14 and 21, serum albumin on day 1 and 21 had an impact on the prognosis (P<0.05).

Conclusion
The clinical prognosis of the four groups decreased in order of NCCI+NPICS, CCI, PICS, CCI + PICS. Our finding of clinically isolated PICS may indicate that PICS acts as a inducement or independent factor to worsen the prognosis of CCI.
Updates in neuro-otology
Authors: Murphy Olwen C. , Hac Nicholas E.F. , Gold Daniel R. 
Published: November 2022

Purpose of review
Recent updates with clinical implications in the field of neuro-otology are reviewed.

Recent findings
Important updates relating to several neuro-otologic disorders have been reported in recent years. For benign positional paroxysmal vertigo (BPPV), we provide updates on the characteristics and features of the short arm variant of posterior canal BPPV. For the acute vestibular syndrome, we report important updates on the use of video-oculography in clinical diagnosis. For autoimmune causes of neuro-otologic symptoms, we describe the clinical and paraclinical features of kelch-like protein 11 encephalitis, a newly-identified antibody associated disorder. For cerebellar ataxia, neuropathy, vestibular areflexia syndrome, we report recent genetic insights into this condition.

Summary
This review summarizes important recent updates relating to four hot topics in neuro-otology.
Systematic Review of Treatment of Patients with Achalasia: Heller Myotomy, Pneumatic Dilation, and Peroral Endoscopic Myotomy (POEM)
Authors: Ciomperlik Hailie , Dhanani Naila H , Mohr Cassandra , Hannon Craig , Olavarria Oscar A , Holihan Julie L , Liang Mike K 
Published: November 2022

Background:
The aim of this systematic review is to assess all comparative randomized controlled trials (RCTs) evaluating Heller myotomy, pneumatic dilation and per endoscopic oral myotomy (POEM).

Study Design:
Achalasia is an esophageal motility disorder associated with degeneration of the myenteric plexus, it causes significant symptoms and impacts patient quality of life (QOL). It remains unclear on the optimal treatment for patients with achalasia and the impact of these interventions on QOL. PubMed, Embase, Scopus and Cochrane were searched from inception to April 2020. RCTs that compared the three interventions were included. Primary outcome was QOL at 12-36 months post-operative. Secondary outcomes included reintervention, dysphagia, leak/perforation, and GERD recurrence.

Results:
9 publications of 6 studies were included. Of the 9 publications there was no significant difference in QOL at 12-36 months except for one study in in which QOL was significantly higher in patients who underwent Heller myotomy as opposed to pneumatic dilation at 3 years; however, at 5 years there was no difference. Pneumatic dilation was associated with the highest rates of dysphagia recurrence and reintervention while POEM had the lowest.

Conclusions:
The treatment of achalasia should be chosen in accordance with patient goals. After any of the three interventions, QOL appears to be similar. However, POEM may be associated with the lowest rates of perforation/leak, dysphagia, and reintervention and may be the lowest risk option. However, there are barriers to widespread utilization due to challenges in training and adoption.
Long-term experience operating CDC recommended 5 air changes per hour in a K-5 elementary school using HEPA and MERV 16 Do-It-Yourself (DIY) portable air cleaners
Authors: Srikrishna Devabhaktuni 
Published: November 2022

AbstractOn May 12, 2023 CDC recommended 5 air changes per hour (5 ACH) and in July 2021 California (CDPH) recommended 6 to 12 ACH to reduce long-range, aerosol transmission of COVID-19 and other pathogens in classrooms. EPA recommends MERV 13+ DIY air cleaners for temporary use during wildfires, and a recent EPA study reported inconsistent usage in homes due to excessive noise generated by the DIY air cleaners. Questions also remain about wear and tear including how long filters retain their filtration properties and need to be replaced. Herein we report real-world experience from daily usage of 47 HEPA and 60 MERV 16 DIY air cleaners in a California elementary school during two academic school years from spring 2021 through fall of 2023 across 16 classrooms, a library, an auditorium, a lunchroom, and in a hallway. Three to six purifiers were needed in classrooms to meet 6 to 12 ACH. Teachers reported noise generated by MERV 16 DIY purifiers on lowest fan speed as acceptable for classroom use. Filtration efficiency at 0.3 μm (most penetrating particle size) for DIY air cleaners with 5” MERV 16 filters used in the classrooms averaged 77% after six months (1st batch in February 2022) compared to 92% for newly installed filters (2nd batch in October 2022). Follow up testing on both batches of filters after an additional academic year (June 2023) showed only slight changes in average filtration efficiency. Portable air cleaners (HEPA and DIY) averaged and estimated 10 ACH (6-15 ACH) across the 16 classrooms demonstrating feasibility and unit economics of meeting CDPH targets per classroom for $200-$650 with DIY versus $600-$12,000 with the HEPA models used. In one 9000 cubic foot classroom with 7 air purifiers, air exchange rate was measured using ambient aerosols at 18 ACH from air purifiers (within 20% of ACH estimated based on CADR of purifiers) and 7 ACH from HVAC for a combined total of 25 ACH. Based on this long-term experience, specific recommendations for enhancing and improving CDC’s web page “Ventilation in Buildings” include: (1) recommended operation of MERV 13+ DIY at their low speed for low noise, cost-effective air cleaning (2) electro-mechanical safety especially in relation to power outlets (3) an open-source procedure known as the “spike test” using ambient aerosols to verify ACH in a room, like the Portacount for mask fit testing. Spike testing can become the basis for ACH certification or verification in any room without generating aerosol contaminants (e.g. salt water, smoke, tracers which may be unsafe or disallowed indoors).
DETECT: Feature extraction method for disease trajectory modeling
Authors: Singhal Pankhuri , Guare Lindsay , Morse Colleen , Byrska-Bishop Marta , Guerraty Marie A. , Kim Dokyoon , Ritchie Marylyn D. , Verma Anurag 
Published: November 2022

AbstractModeling with longitudinal electronic health record (EHR) data proves challenging given the high dimensionality, redundancy, and noise captured in EHR. In order to improve precision medicine strategies and identify predictors of disease risk in advance, evaluating meaningful patient disease trajectories is essential. In this study, we develop the algorithmDiseasE Trajectory fEature extraCTion (DETECT)for feature extraction and trajectory generation in high-throughput temporal EHR data. This algorithm can 1) simulate longitudinal individual-level EHR data, specified to user parameters of scale, complexity, and noise and 2) use a convergent relative risk framework to test intermediate codes occurring between a specified index code(s) and outcome code(s) to determine if they are predictive features of the outcome. We benchmarked our method on simulated data and generated real-world disease trajectories using DETECT in a cohort of 145,575 individuals diagnosed with hypertension in Penn Medicine EHR for severe cardiometabolic outcomes.
West Nile Virus spread in Europe - phylogeographic pattern analysis and key drivers
Authors: Lu Lu , Zhang Feifei , Oude Munnink Bas B. , Munger Emmanuelle , Sikkema Reina S. , Pappa Styliani , Tsioka Katerina , Sinigaglia Alessandro , Dal Molin Emanuela , Shih Barbara B. , Günther Anne , Pohlmann Anne , Beer Martin , Taylor Rachel A. , Bartumeus Frederic , Woolhouse Mark , Aarestrup Frank M. , Barzon Luisa , Papa Anna , Lycett Samantha , Koopmans Marion P. G. 
Published: November 2022

AbstractSpread and emergence of West Nile virus (WNV) in Europe have been very different from those observed in North America. Here, we describe key drivers by combining viral genome sequences with epidemiological data and possible factors of spread into phylodynamic models. WNV in Europe has greater lineage diversity than other regions of the world, suggesting repeated introductions and local amplification. Among the six lineages found in Europe, WNV-2a is predominant, has spread to at least 14 countries and evolved into two major co-circulating clusters (A and B). Both of these seem to originate from regions of Central Europe. Viruses of Cluster A emerged earlier and have spread towards the west of Europe with higher genetic diversity. Amongst multiple drivers, high agriculture activities were associated with both spread direction and velocity. Our study suggests future surveillance activities should be strengthened in Central Europe and Southeast European countries, and enhanced monitoring should be targeted to areas with high agriculture activities.