bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of technological transport schemes for multimodal carriage applying water transport within the achievement of industrial strategic targets
Authors: Тюленев К.Г. 
Published: September 2022

Формирование оптимальной структуры транспортно-технологических схем мультимодальных перевозок на основе морского транспорта, проводимое в рамках реализации Транспортной стратегии Российской Федерации, в настоящее время является одним из ключевых векторов межотраслевого взаимодействия. В условиях новых внешнеэкономических ограничений особую значимость приобретает внедрение комплексных мер поддержки экспорта транспортных услуг, предусматривающее совершенствование оценки, анализа и прогнозирования целевых индикаторов. Учитывая современные тенденции перераспределения экспортных грузопотоков и высокие темпы обновления базовых транспортно-технологических схем организации мультимодальных перевозочных процессов в системе международных транспортных коридоров, проходящих по территории Российской Федерации, в научной статье представлена концепция достижения стратегических целей развития транспортного комплекса, основанная на использовании методики расчета валовой прибыли в единицу времени. Интегрированное развитие субъектов рынка мультимодальных перевозок cприменением вышеупомянутой методики, использованное в процессе деятельности российских подразделений международных транспортных компаний, содействует усилению конкурентоспособности сети распределения продукции, росту экспорта транспортных услуг, реализации стратегических задач транспортной отрасли.
Formation of optimal structure for technological transport schemes in the multimodal carriage based on maritime transport, within the implementation of Transport Strategy of the Russian Federation, at present time belongs to the key vectors of intersectoral industrial cooperation. In the context of new external economic limitations, the introduction of comprehensive measures supporting export of transport services, including the improvement of assessment, analysis and forecasting of target indicators, is coming to the status of special importance. Considering current trends of redistributing export cargo flows and high renewal frequency referring to basic technological transport schemes of multimodal carriage processes in the system of International Transport Corridors, crossing territory of the Russian Federation, the provisions of scientific article represent concept of achieving strategic targets for transport complex development based on application of the Methodology for estimating gross profit per time period. Integrated entities development in the market of multimodal transportation services, directed by above mentioned Methodology, used in the course of managing production activity for the Russian divisions of international transport companies, contributes to the strengthening of competitiveness for product distribution network, increasing volume of released export transport services, implementing strategic targets of transport industry.
The controlled ramp-function generator for control systems
Authors: Усольцев В.К. , Чупина К.В. 
Published: September 2022

В статье рассматриваются вопросы синтеза управляемого задатчика интенсивности для систем автоматического управления электроприводами. Неуправляемые задатчики интенсивности затягивают переходные процессы, снижая быстродействие электропривода. Показано, что максимально использовать возможности астатических регуляторов в системе управления, не допуская их вход в зону насыщения, возможно, если задатчик интенсивности будет изменять темп задающего сигнала в переходных процессах. Предложена структура системы управления, позволяющая учитывать скорость изменения управляющего сигнала на выходе регулятора. Разработана методика, позволяющая выполнить синтез регулятора, управляющего задатчиком. Применение управляемого задатчика интенсивности увеличивает быстродействие системы управления, уменьшает перерегулирование, исключает «интегральное насыщение» для ПИ и для ПИД регуляторов. Исследование показало, что использование управляемого задатчика не влияет на поведение системы управления при внешних возмущающих воздействиях. Цифровое моделирование показало работоспособность и эффективность управляемого задатчика при различных законах управления.
The article is devoted to problem of synthesis of ramp-function generator for electric drive control systems. Because of the uncontrolled ramp-function generators slow transients take place in control systems. It's well-known that the astatic controllers will be used better if they won't operate in the integral windup. It is possible if the ramp-function generator will change a rate of specified signal during transients. The offered mathematic model takes into account the rate of the controller output. The technique for synthesis of the controller for ramp-function generator is developed. Due to using of a controlled ramp-function generator fast transients with minimum overshoot will take place in control systems and integral windup for PI and PID controllers is eliminated. Controlled ramp-function generator doesn’t affect the states of control system caused external disturbances. Digital simulations showed the effectiveness of a controlled ramp-function generator for different control algorithms.
Numerical modeling for forming of expanding joints of piles with the foundations of fixed offshore platforms and their operating capacity
Authors: Крыжевич Г.Б. , Филатов А.Р. 
Published: September 2022

Объектами работы являются узлы соединения свай с опорными конструкциями морских стационарных платформ (МСП). Актуальность работы связана с обнаружением на некоторых объектах трещин, вызванных формированием этих соединений. Цель работы состоит в выявлении на основе численного моделирования гидроразжима свай рациональных технологических параметров процесса их крепления к направляющим опорных блоков, применяемых в конструкциях МСП. Для этого выполнялось численное моделирование процесса гидравлического разжима методом конечных элементов. Учёт пластического деформирования свай выполнен с применением линейной кинематической модели упрочнения с рассмотрением нескольких вариантов модуля упрочнения. В результате получены диаграммы вытягивания свай из опор при различных значениях рабочего давления гидроразжима. Для двух различных модулей упрочнения получены оптимальные значения рабочего давления. Анализ полученных результатов говорит о высокой чувствительности задачи к значению модуля пластического упрочнения и его определяющем влиянии на оптимальное значение рабочего давления гидроразжима.
The work studies joints of piles with the supporting structures of fixed offshore platforms (FOP). The relevance of the work is related to detection of cracks in some joints caused by these joints formation. The work aims to identify rational process parameters of their fastening to guides of support blocks used in FOP structures through numerical simulation of piles hydraulic expansion. To this effect hydraulic expansion was simulated numerically by the finite element method. Piles plastic deformation was accounted for using a linear kinematic hardening model with consideration of several hardening modulus options. As a result, diagrams of piles pulling from supports were obtained at various hydraulic expansion pressure values. Optimal working pressure values were obtained for two different hardening moduli. Analysis of the obtained results shows high problem sensitivity to the plastic hardening modulus value and its decisive influence on the optimal hydraulic expansion pressure value.
Digital models of unsteady dynamics of underwater vehicle in the cloud computing environment
Authors: Нечаев Ю.И. , Никущенко Д.В. 
Published: September 2022

Рассматриваются концептуальные основы и процедуры построения цифровой модели «облачной» среды эволюционной динамики подводных объектов (ПО) на основе многофункционального программного комплекса (МПК) [1] – [9]. Разработанная стратегия позволяет реализовать процедуры цифрового моделирования в «облачной» среде экстренных вычислений (Urgent Computing – UC. Используемый абстрактный образ цифровой модели отражает основные тенденции развития управленческих решений при разработке практических приложений нестационарной динамики ПО. Подход к интерпретации цифрового моделирования основан на эффективном использовании достижений в области интеллектуальных технологий. Вычислительная среда цифрового моделирования представлена как активная динамическая система на основе нечеткой формальной системы (НФС) управления, обеспечивающей функционирование цифровой модели «облачной» среды при непрерывном изменении динамики ПО и внешних возмущений в условиях неопределенности. Приведены направления реализации цифровой модели в процессе выработки управленческих решений при проектировании, постройке и эксплуатации ПО новых поколений.
The conceptual foundations and procedures for constructing a digital model of the "cloud" environment of the evolutionary dynamics of underwater vehicle (UV) based on a multifunctional software package (MPC) are considered [1] - [9]. The developed strategy makes it possible to implement digital modeling procedures in the "cloud" environment of emergency computing (Urgent Computing - UC. The abstract image of the digital model used reflects the main trends in the development of management decisions in the development of practical applications of non-stationary program dynamics. The approach to the interpretation of digital modeling is based on the effective use of achievements in the field of intelligent technologies. The computational environment of digital modeling is presented as an active dynamic system based on a fuzzy formal control system (NFS), which ensures the functioning of a digital model of a "cloud" environment with continuous changes in the dynamics of software and external disturbances under conditions of uncertainty. The directions of implementation of the digital model in the process of managerial decision-making in the design, construction, and operation of software of new generations are given.
Exacerbation of Psoriasis Vulgaris Induced by Vaccine COVID-19 in HIV Patient: A Case Report
Authors: Akhyar Gardenia , I. Izrul  , M. Ashar  
Published: September 2022

Background: Psoriasis is a chronic and inﬂammatory skin disease. Many triggering factors can cause exacerbation of psoriasis, such as infection, trauma, and drugs. Several vaccines are known to cause new lesions or exacerbation of psoriasis, including Bacillus Calmette-Guerin (BCG), influenza, tetanus-diphtheria, and pneumococcal polysaccharide. In the COVID-19 pandemic, the COVID-19 vaccine is known to cause the appearance of new lesions or exacerbation of psoriasis.
Case presentation: A woman, 31 years old, came to the clinic with itchy reddish patches with white scales on her face, chest, stomach, back, arms, and both legs, and increased since 2 weeks ago. Previously, the patient got the first COVID-19 vaccine (Sinovac), and three days later, red patches appeared with white scales on the chest, stomach, and back. The patient had been diagnosed with psoriasis 3 years ago. Dermatology examination showed reddish patches with white scales on the face, chest, stomach, back, arms, and both legs. Auspitz sign and Kaarvetsvlek phenomen were positive. PASI score was 9,2. Dermoscopy examination showed red dot distribution on light pink background and white scales. She was treated with desoximetasone cream 0,05% twice a day and cetirizine tablet 10 mg once a day. After 2 months of therapy, reddish patches were decreased, and the PASI score was 6,9.
Conclusion: COVID-19 vaccine can cause exacerbations in psoriasis patients, but this vaccine can still be given to psoriasis patients. It is based on the documented eﬃcacy of the COVID-19 vaccine in the prevention of severe COVID-19 infection and fatality. Psoriasis patients should be consulted before getting vaccinated for COVID-19, and prompt clinical visits should be available if exacerbation develops.
A Review on Challenges and Opportunities in Management of Soils of Arid and Semi-Arid Regions of Kenya
Authors: Nyuma Henry Tamba , Churu Harrison 
Published: September 2022

Arid and semi-arid lands occupy currently 88% of arable land mass in Kenya, a region with significant diversity of production systems and economic opportunities. However, these areas are characterised by low and erratic rainfall, hence challenges to agriculture and socioeconomic development in the wake of an increasing population and the impacts of climate change. This review seeks to identify key challenges and opportunities associated with the management of agricultural soils in these arid and semi-arid communities. Arid and semi-arid regions in Kenya are dominated by 10 soil types; Solanchaks, Solonetz, Cambisols, Arenosols, Leptosols, Vertisols, Fluvisols, Phoezems, Calcisols, and Gypsisols. Among the main soil fertility challenges in these soils are moisture stress, high erodibility, and low organic matter content, salinity, and sodium toxicity, the deficiencies of mainly N, P, Zn, and Fe, hence the vulnerability of over 14 million inhabitants to the shocks of low crop and pasture production. Moreover, the adoption of soil conservation practices remains low as existing soil fertility management technologies have been criticized for being too abstract and not providing context and site-specific solutions. Improving soil fertility and moisture levels enhances soil ecosystem functions and food and pasture production in these regions. Encouraging farmers to join soil and water conservation groups, while providing economic incentives, could potentially accelerate the adoption of soil and water practices at the farm level through pulling resources together. Future research to validate a site and context-specific integrated soil fertility improvement technologies for these soils is evitable to enhance soil functions, agricultural production and livelihood at house hold level.
Core Concept Of Bioelectronic Medicine And Their Theranostic Application In Cancer
Authors: Shinde Pooja Ramesh , Patel Vipul 
Published: September 2022

Bioelectronic medicine is a way of treating in which the electrical communication networks of the body are altered to treat disease. Bioelectric circuitry in every cell creates a resting membrane potential as well as endogenous electric fields that regulate cell function and communication. The theory that cancer is caused by bioelectrical circuitry malfunctions in cells is now widely acknowledged. This opens up the possibility of using bioelectronic medicine to develop new cancer treatments by influencing the disease's bioelectrical properties. To meet societal and technical obstacles, today's individuals aspire to better their quality of life. So, in the midst of all of this, bioelectronic medicine has altered the way we practice medicine and has proven to dramatically enhance healthcare outcomes. This technique employs a variety of procedures, such as neuromodulation, to treat a specific disease, ailment, or damage. Interfacing electronics with nerves to specifically target the biological processes underlying diseases. In cancer, screening and early detection are crucial for the patient's therapy to be successful and for the patient's survival percentage to grow. For illness diagnosis, therapy, and follow-up, the development of analytical methods for non-invasive detection through the analysis of cancer biomarkers is crucial. Tumor biomarkers are substances or processes that indicate the existence of cancer in the body in clinical situations. These biomarkers can be detected using biosensors, which are popular alternatives to traditional approaches due to their speed, accuracy, and point-of-care applicability. Here we have discussed the consequences of current cancer treatments and bioelectronic medicine a combat for cancer diagnosis and treatment.
Formulation Development, Evaluation and Statistical Optimization of the Release Rate of Oral Sustained Release Matrix Tablet of Aceclofena
Authors: Bhowmick Argha , Manna Arup , Mandal Sanat Kumar , Das Biswajit , Ghosh Arupa , Changder Abhijit , Bhandari Divya Dhawal , Sharma Chandan 
Published: September 2022

Aim: This work aimed to develop a sustained released hydrophilic matrix tablet of Aceclofenac for better therapeutic action.
Background: Conventional dosage form didn't provide the desired level of drug release. Even many-marketed sustained-release tablets didn't always meet the satisfactory level of drug release. It was a challenging job for pharmaceutical scientists to develop a well-sustained release formulation. Keeping this perspective in mind a robust sustained release formulation was designed, developed and optimized with nontoxic, inert viscoelastic, semisynthetic polymers which will be accepted worldwide.
Objective: The objective of this research was to develop an Aceclofenac sustained released matrix tablet, which will deliver the desired level of drug release.
Method: Aceclofenac sustained released tablet was prepared with Methocel K-100M Premium (Hydroxypropyl Methylcellulose) and Unigel 270 (Pregelatinized starch). These two excipients were selected as independent formulation variables with three separate levels (high, intermediate and low). Nine batches of hydrophilic matrix tablets of Aceclofenac were prepared according to the 32 Factorial Design with an average weight of 365 mg/tablet. Each prepared batch of tablets was then evaluated for drug content, physical parameters and drug release. Mathematical models were then generated using Analysis of Variance employing Design-Expert Software version 8.0.7.1 for % cumulative release at T1 hr, T4 hr and T7 hr. FTIR spectroscopy was carried out to evaluate drug-excipients interaction after formulation.
Results: Design-Expert Software after analyzing the release data of prepared 9 batches provides an optimized composition of formulation. The optimized batch showed desirable results for cumulative % release (CPR)T1hr, CPR T4hr and CPR T7hr are 35.61, 52.16 and 61.98 respectively.
Conclusion: Application of statistical experimental design, the physicochemical studies and the in vitro-release study, the mathematically predicted formulation and its manufacturing and validation of aceclofenac sustained-release tablets showed great advancement from the trial-and-error method of development of sustained-release drug delivery systems.
In-silico Screening of Some Important Bioactive Compounds as Potential Inhibitors of 3CLpro Protein of SARS-CoV-2 and MERS-CoV Virus
Authors: Ghosh Chandreyi , Saha Moumita , Kulavi Sohini , Chatterjee Sirshendu 
Published: September 2022

Background: Coronavirus (SARS-CoV-2), the leading cause of the epidemic in 2019, also known as COVID-19, has raised ongoing global concerns. The most favourable target protein for this flu is 3CLpro (conserved 3-chymotrypsin-like protease), also known as Mpro. Covaxin and Covishield vaccination is going in India. Remdesivir, as well as some antimalarial drugs such as Hydroxychloroquine and Chloroquine, are used for extreme necessity. However, Hydroxychloroquine and Chloroquine and their derivatives are not convenient for those who are suffering from hypertension, diabetes, cardiac arrest, and many more.
Objective: Here, we choose some bioactive compounds for docking studies with the Mpro of SARS CoV2 and MERS as it is used as the primary target for a comparative study.
Methods: The docking process was carried out by preparing both 3CLpro proteins, i.e., 2YNA and 6LU7, and then the ligand molecules were downloaded from Pubchem, DrugBank, and Zinc15 databases. Furthermore, SwissAdme and pkCSM software were used for the determination of toxicity and Pharmacokinetic properties (ADMET) properties. Lastly, docking was carried out by the Autodock version 4.2 program, and the docking score was compared to the reference inhibitor Ritonavir.
Results: Among 17 bioactive compounds used for docking studies, Quercetin, Trans-Resveratol, Kaemferol, and Theaflavin have top, binding affinity for target proteins, i.e., Theaflavin (-14.35 kcal/mol), Quercetin (-11.88kcal/mol), Kaempferol (-9.3 kcal/mol) and Trans-Resveratol (-9.31 kcal/mol) and also obey Lipinski's rule which makes them potential drug candidate against Covid-19 virus. Hence, the application of these plant-based bioactive compounds alone or along with scheduled vaccination may be the best therapeutic approach in the current scenario.
Hundreds of Low-mass Active Galaxies in the Galaxy And Mass Assembly (GAMA) Survey
Authors: Salehirad Sheyda , Reines Amy E. , Molina Mallory 
Published: September 2022

Abstract
We present an entirely new sample of 388 low-mass galaxies (M
⋆ ≤ 1010
M
⊙) that have spectroscopic signatures indicating the presence of massive black holes (BHs) in the form of active galactic nuclei (AGNs) or tidal disruption events. Of these, 70 have stellar masses in the dwarf galaxy regime with 108 ≲ M
⋆/M
⊙ ≲ 109.5. We identify the active galaxies by analyzing optical spectra of a parent sample of ∼23,000 low-mass emission-line galaxies in the Galaxy and Mass Assembly (GAMA) Survey Data Release 4, and employing four different diagnostics based on narrow emission-line ratios and the detection of high-ionization coronal lines. We find that 47 of the 388 low-mass active galaxies exhibit broad Hα in their spectra, corresponding to virial BH masses in the range M
BH ∼ 105.0–7.7
M
⊙ with a median BH mass of 〈M
BH〉 ∼ 106.2
M
⊙. Our sample extends to higher redshifts (z ≤ 0.3; 〈z〉 = 0.13) than previous samples of AGNs in low-mass/dwarf galaxies based on Sloan Digital Sky Survey spectroscopy, which can be attributed to the spectroscopic limit of GAMA being ∼2 mag deeper. Moreover, our multi-diagnostic approach has revealed low-mass active galaxies spanning a wide range of properties, from blue star-forming dwarfs to luminous “miniquasars” powered by low-mass BHs. As such, this work has implications for BH seeding and AGN feedback at low masses.
A Mid-infrared Flare in the Seyfert Galaxy NGC 3786: A Changing-look Event Triggered by an Obscured Tidal Disruption Event?
Authors: Son Suyeon , Kim Minjin , Ho Luis C. , Kim Dohyeong , Kim Taehyun 
Published: September 2022

Abstract
We report an exceptional mid-infrared flare in the Seyfert 1.8 NGC 3786. In the multiepoch data from the Wide-field Infrared Survey Explorer, the nuclear mid-infrared brightness of NGC 3786 appears to vary substantially up to 0.5–0.8 mag around mid-2020. However, there is no evidence of significant variation in the corresponding light curve of the optical band from the Zwicky Transient Facility. This implies that the flare may have been heavily obscured by nuclear dust. Through follow-up spectroscopic observations with Gemini-North after the flare, we find that broad emission lines in Paα and Paβ newly appear, while the broad Hβ emission is marginally detected in the postflare spectrum. In addition, their central wavelengths are systematically redshifted up to 900 km s−1 with respect to the narrow emission lines. This reveals that the flare is associated with the changing-look phenomenon from type 1.8 to type 1. Based on these findings, we argue that the flare is likely to originate from an obscured tidal disruption event, although extreme variation in the accretion rate may not be ruled out completely.