bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palate evolution in early‐branching crocodylomorphs: Implications for homology, systematics, and ecomorphology
Authors: Dollman Kathleen N. , Choiniere Jonah N. 
Published: May 2022

AbstractLiving crocodylomorphs have an ossified secondary palate with a posteriorly positioned choana that enables their semi‐aquatic, predatory ecology. In contrast, the earliest branching members of Crocodylomorpha have an open palate with anteriorly positioned choanae. The evolution of an ossified secondary palate and a posteriorly positioned choana features strongly in hypotheses of broad‐scale phylogenetic relationships within Crocodylomorpha. Renewed investigations into palatal morphology among extinct members of the clade show surprising variability in the anatomy of the palate, with at least one and potentially a second independent occurrence of “eusuchian‐type” palate outside of Eusuchia. Understanding the trajectory of crocodylomorph palatal evolution is, therefore, a key to inferring crocodylomorph interrelationships and ecomorphology. To document early‐branching crocodylomorph palatal anatomy, we developed an anatomical comparative dataset using computed tomography scan data and literature, comprising 12 early‐branching crocodylomorph taxa. To understand discrete phenotypic changes in palatal structure, we compiled a phylogenetically broadly sampled character‐taxon matrix from the existing literature, and revised its palatal characters, adding 10 new palatal characters. Our comparative anatomical investigations allow us to propose an adapted hypothesis for the closure of the palate and the posterior migration of the choana. Our phylogenetic findings corroborate previous research showing that non‐crocodyliform crocodylomorphs (“sphenosuchians”) are paraphyletic, with the exclusion of the clade Hallopodidae. Non‐mesoeucrocodylian crocodyliforms (“protosuchians”) are paraphyletic, but form three monophyletic clades: Notochampsoidea, Shartegosuchoidea, and Gobiosuchidae. We find a potential association between secondary palate development and dietary shifts, particularly with regard to hypothesized origins of herbivory.
Time to vote: Temporal clustering of user activity on Stack Overflow
Authors: Geras Agnieszka , Siudem Grzegorz , Gagolewski Marek 
Published: May 2022

AbstractQuestion‐and‐answer (Q&A) sites improve access to information and ease transfer of knowledge. In recent years, they have grown in popularity and importance, enabling research on behavioral patterns of their users. We study the dynamics related to the casting of 7 M votes across a sample of 700 k posts on Stack Overflow, a large community of professional software developers. We employ log‐Gaussian mixture modeling and Markov chains to formulate a simple yet elegant description of the considered phenomena. We indicate that the interevent times can naturally be clustered into 3 typical time scales: those which occur within hours, weeks, and months and show how the events become rarer and rarer as time passes. It turns out that the posts' popularity in a short period after publication is a weak predictor of its overall success, contrary to what was observed, for example, in case of YouTube clips. Nonetheless, the sleeping beauties sometimes awake and can receive bursts of votes following each other relatively quickly.
Synergistically Active Piezoelectrical H2O2 Production Composite Film Achieved from a Catalytically Inert PVDF−HFP Matrix and SiO2 Fillers
Authors: Wang Lingchao , Chen Zhensheng , Zhang Yihe , Liu Chao , Yuan Jinpeng , Liu Yulun , Ge Weiyi , Lin Sen , An Qi , Feng Zeguo 
Published: May 2022

AbstractLocal and decentralized H2O2 production via a piezoelectrical process promises smart biological utilization as well as environmental benefits. However, stable, bio/environmentally safe, and easily applied H2O2 generation materials are still lacking. Here, we report a novel flexible H2O2 generation polymeric film composed of catalytically inert PVDF−HFP (Poly(vinylidene fluoride‐co‐hexafluoropropylene)) matrix and SiO2 nanoparticle fillers. The film is bio‐/environmentally benign at resting states, but effectively produces H2O2 upon ultrasonic motivation at a production rate of 492 μmol
in one hour. Experimental and simulation methods in combination indicate that the effective H2O2 generation capabilities stem from the synergistic existence of piezoelectrical fields and the air‐liquid‐solid three‐phase regions around the porous film. The chemical conversions are motivated by the adsorbed charges. The silicon hydroxyl groups properly stabilize the *OOH intermediate and facilitate the chemical conversions of 2e− ORR of ambient O2. We expect the report to inspire H2O2 piezoelectrical generation materials and promote the novel production strategies of H2O2 as well as piezoelectrical functional materials.
Clinical and behavioral attributes leading to sleep disorders in children on the autism spectrum
Authors: Masi Anne , Moni Mohammod Ali , Azim Syeda Ishra , Choi Byungkuk , Heussler Helen , Lin Ping‐I , Diaz Antonio Mendoza , Eapen Valsamma 
Published: May 2022

AbstractSleep disorders are a common comorbid condition in children diagnosed with autism spectrum disorder (“autism”). However, the relationship between the clinical features of autism and sleep disorders remains unclear. A better understanding of the inherent autism‐related characteristics linked to comorbid sleep disorders would improve comprehensive assessment and management. This study examined the relationship between sociodemographics, autism symptoms, sleep problems, cognitive status, behavioral attributes, and sensory profiles. Using data from 1268 participants who took part in the Australian Autism Biobank, sleep‐related measurements using the Child Sleep Habits Questionnaire (CSHQ) were compared between autistic children aged 2 to 17 (N = 969), their siblings (N = 188), and unrelated children without an autism diagnosis (N = 111). The known relationship between sleep problems and autism was further explored by including scores from the Autism Diagnostic Observation Schedule‐2, Mullen Scales of Early Learning, Vineland Adaptive Behavioral Scale‐II and the Short Sensory Profile‐2; which were included in analyses for autistic participants who had a completed CSHQ. Multiple regression models were used to identify clinical/behavioral variables associated with CSHQ subscales. The autism group had a significantly higher total CSHQ score than the sibling and comparison groups (p < 0.001), indicating worse sleep quality. Within the autism group, lower adaptive behaviors (i.e., VABS‐II) and sensory issues (i.e., SSP‐2 subclass scores) were positively associated with the severity of sleep problems (i.e., the CSHQ subclass scores) (p < 0.001). The significant functional impact of poor sleep on autistic children warrants an assessment of sleep as a critical part of a holistic approach to supporting autistic children and their families.Lay SummaryAutistic children generally have co‐occurring conditions. Sleep disorders impact approximately 50%–80% of autistic children. The impact on the quality of life for both the children and their families can be significant. This study compares sleep problems in autistic children and adolescents with their siblings and children without a diagnosis of autism, and investigates the relationship between specific autistic traits, daily life behaviors and sleep problems. The findings highlight the importance of a holistic assessment for autistic children and matching appropriate sleep intervention and supports where indicated.
In silico–in vitro estimation of lipophilicity and permeability association for succinimide derivatives using chromatographic anisotropic systems and parallel artificial membrane permeability assay
Authors: Vidović Dunja , Milošević Nataša , Pavlović Nebojša , Todorović Nemanja , Panić Jelena Čanji , Ćurčić Jelena , Banjac Nebojša , Trišović Nemanja , Božić Bojan , Lalić‐Popović Mladena 
Published: May 2022

AbstractPassive permeability is one of the key features that determine absorbability and one of the most studied properties in the early phases of drug development. Newly synthesized succinimide derivatives from two different series (1‐aryl‐3‐methylsuccinimides and 1‐aryl‐3‐ethyl‐3‐methylsuccinimides) with high biological potential have been subjected to estimation of their passive permeability and their association with (a) experimentally obtained anisotropic lipophilicity, (b) in silico–calculated lipophilicity and (c) in silico–predicted permeability and absorbability. Non‐cellular‐based parallel artificial membrane permeability assay was applied for quantifying their passive permeation, expressed as logPapp. Passive permeation was governed by the lipophilicity of the analysed compounds, and anisotropic lipophilicity was related with statistically significant passive transcellular diffusion (r2 = 0.614, P < 0.001). Moreover, experimentally determined passive permeability, logPapp, was statistically significantly associated with both in silico–predicted absorption constant, ka (r2 = 0.7886, P < 0.001), and human intestinal absorption (HIA) in percentage (r2 = 0.484, P < 0.001), respectively. However, there was no statistically significant relationship between experimentally obtained permeability on non‐cellular‐based model and in silico–predicted Caco‐2 permeability based on the predictions conducted on two different software. Based on the obtained results, anisotropic systems are promising surrogates for determining lipophilicity, except for compounds with acidic functional groups that are completely ionized under (pH = 7.4).
Driving mechanism model of enterprise green strategy evolution under digital technology empowerment: A case study based on Zhejiang Enterprises
Authors: He Zhengxia , Kuai Leyi , Wang Jianming 
Published: May 2022

AbstractDigital technology innovation is sweeping the world, endowing the development of enterprises with the new feature of “digital + green,” which improves the efficiency of enterprises in implementing green strategy. Previous studies emphasized the driving force of enterprise green strategy evolution under the traditional economic model, but often ignored its driving mechanism under digital technology empowerment. Collecting the data from first‐hand interviews and second‐hand documents and selecting 11 case enterprises in Zhejiang, China, this study adopts multiple case method to construct a driving mechanism model of enterprise green strategy evolution under digital technology empowerment. This study proposed as follows, first, the enterprise green strategy is innovatively divided into five evolution stages (green beginner, green responder, green adapter, green activist, and green leader), and it is found that most case enterprises reached a higher stage. Second, digital technology empowerment affects the enterprise green strategy evolution through the mediating role of managerial perception, enterprise competitive capabilities, data and information elements, enterprise resource utilization efficiency, green product design, and whole process digitalization and digital marketing. Third, corporate governance (including public ownership, ownership concentration, independence, and diversity of the board of directors) significantly and positively moderate between various factors and enterprise green strategy evolution. Finally, a series of policy implications and managers' coping strategies are proposed.
Simple IHC reveals complex MMR alternations than PCR assays: Validation by LCM and next‐generation sequencing
Authors: Amemiya Kenji , Hirotsu Yosuke , Nagakubo Yuki , Watanabe Shunsuke , Amemiya Saki , Mochizuki Hitoshi , Oyama Toshio , Kondo Tetsuo , Omata Masao 
Published: May 2022

AbstractEvaluation of the status of mismatch repair (MMR) in tumors is crucial for determining the application of immune checkpoint inhibitors (ICIs). Conventional PCR (MSI‐PCR) is the gold standard for confirming the MMR status. However, it requires visual confirmation and presents difficulties in determining MMR status. Immunohistochemistry (IHC) is a simple method and can confirming MMR protein expression in the whole tumor. We aim to investigate IHC is more suitable for evaluating MMR status in the tumor. We compared MSI‐PCR and IHC by testing 319 samples from 284 patients across 14 cancer types. In discordant cases, we performed laser‐capture microdissection and microsatellite instability assay by next‐generation sequencing (MSI‐NGS). The concordance rate between IHC and MSI‐PCR testing was 98.1% (313/319). Two reasons for these discrepancies were ambiguous MSI‐PCR results and heterogeneous MSI status within the tumor. Among six cases (1.9%), three were judged as MSI‐H by MSI‐PCR but with proficient MMR by IHC. The results of MSI‐NGS revealed microsatellite stable in these three cases. The remaining three cases, two of three were MSI‐H and one was MSS in whole tumor in MSI‐PCR. IHC showed a “mosaic” pattern containing both proficient MMR and deficient MMR portions by IHC in all three cases. We performed microdissection and MSI‐PCR and found intratumoral heterogeneity of MMR status. These results indicated the advantages of IHC and performed expanded samples (n = 1082) and two additional mosaic cases were identified. Our results clearly indicated that simple IHC is the best choice for determining MMR alterations in critical cases for ICIs treatment.
Double purse‐string suture surgical wound closure after excision of nipple adenoma of the breast: A case report
Authors: Bimpa Kanelina , Charitou Theodosia , Ziogas Apostolos C. , Kantounis Konstantinos , Xydias Emmanouil , Bobos Mattheos , Tsakos Elias 
Published: May 2022

AbstractWe present a rare case of nipple adenoma in a 53‐year‐old Caucasian woman. The lesion presented with a hemorrhagic nipple surface and was treated with wide surgical excision of the nipple and part of the surrounding areola and with a double purse‐string surgical closure of the remaining areolar area. This technique was considered safe and effective and aimed to reconstruct the nipple area, thus providing the patient with an acceptable aesthetic result. Double purse‐string surgical closure is proposed as a unique and straightforward, oncologically safe surgical procedure. This technique combines complete removal of the nipple adenoma, preservation of the remaining areola, minimization of skin flattening at the reconstructed area, improvement of the long‐term aesthetic result, and provision of a satisfactory surgical option for the patient.
Cognitive behavioral therapy for an individual suffering from chronic pain with overactivity and sleep disturbance: A case report
Authors: Enomoto Kiyoka , Kugo Masato , Fukui Sei , Sasaki Jun 
Published: May 2022

AbstractPatients suffering from chronic pain (CP) with overactivity frequently experience sleep disturbance. We presented a 35‐year‐old woman suffering from CP. To improve the sleep disturbance of individuals suffering from CP with overactivity, it is important to combine cognitive behavioral therapy for insomnia and activity pacing.
The usefulness of OK‐432 for the treatment of postoperative chylothorax in a low‐birth‐weight infant with trisomy 18
Authors: Takahashi Yoshiaki , Kinoshita Yoshiaki , Kobayashi Takashi , Arai Yuhki , Ohyama Toshiyuki , Yokota Naoki , Saito Koichi , Sugai Yu , Takano Shoichi 
Published: May 2022

AbstractChylothorax is a rare but life‐threatening condition in neonates. We herein report the successful use of OK‐432 for a low‐birth‐weight infant with trisomy 18 who developed refractory chylothorax after thoracic surgery. Increasing the concentration of OK‐432 seems useful in cases with a lot of pleural effusion.
Cone‐beam computed tomography in the diagnosis of regional odontodysplasia
Authors: Mabrouk Rihab , Chouchene Farah , Maatouk Fethi , Masmoudi Fatma , Baaziz Ahlem , Ghedira Hichem 
Published: May 2022

AbstractRegional odontodysplasia (RO) in permanent teeth is a rare developmental anomaly of mineralized tissues. Three‐dimensional images and data from CBCT allowed to provide useful information on the degree of tooth calcification and consequently confirm the diagnosis of RO and establish a treatment strategy to minimize future damages and sequels.
The positive short‐term effect of dexamethasone on ataxia symptoms in a patient with ataxia‐telangiectasia: A case report
Authors: Saberi‐Karimian Maryam , Beyraghi‐Tousi Mehran , Jamialahmadi Tannaz , Sahebkar Amirhossein 
Published: May 2022

AbstractOral dexamethasone was administered at a dose of 0.075 mg/kg/day for a boy with ataxia‐telangiectasia. The SARA score was improved by 7.0 points after dexamethasone treatment over a period of 28 days. The body weight was increased by 1.4 kg after 4 weeks leading to dose titration to 0.05 mg/kg/day.
Immune‐mediated thrombotic thrombocytopenic purpura in a Jehovah’s Witness – Effectiveness of incorporating extracorporeal immunoadsorption to caplacizumab, steroids and rituximab
Authors: Cardesa‐Salzmann Teresa Marta , Stephan Bernhard , Simon Arne , Furtwängler Rhoikos , Schöndorf Dominik , Heine Sabine , Torfah Eyad , Lux Margaux , Meyer Sonja , Graf Norbert 
Published: May 2022

AbstractWe report the case of a Jehovah's Witness adolescent patient with immune‐mediated thrombotic thrombocytopenic purpura after SARS‐Cov2 infection successfully treated without therapeutic plasma exchange (TPE) using caplacizumab, corticosteroids, rituximab, and extracorporeal immunoadsorption (EIA). Further patients for whom TPE is not an option might benefit from this approach.
Does better environmental, social, and governance induce better corporate green innovation: The mediating role of financing constraints
Authors: Zhai Yuming , Cai Zhenghuan , Lin Han , Yuan Ming , Mao Ye , Yu Mingchuan 
Published: May 2022

AbstractGreen innovation is a key way for firms to establish competitive advantage and contribute to sustainable development, but it often suffers from financing constraints. In this regard, environmental, social, and governance (ESG) practices allow firms to have a wider investor base, face lower risk, and generate positive market reactions, ultimately leading to a lower cost of capital, which may potentially alleviate financing constraints and provide strong motivation for green innovation. Combining stakeholder theory with the resource‐based view (RBV), this study investigated how ESG substantially affects corporate green innovation. Based on a zero‐inflated Poisson regression analysis of 1577 listed Chinese manufacturing firms, we found that better ESG could significantly induce better corporate green innovation, and financing constraints acted as a mediator in the relationship between ESG and green innovation. Our findings contribute to a more detailed understanding of the mechanisms by which corporate pro‐social decision‐makings initiate and boost green innovation.
Guidelines to build the bridge between sustainability and integrated management systems: A way to increase stakeholder engagement toward sustainable development
Authors: Vieira Nunhes Thaís , Espuny Maximilian , Lauá Reis Campos Thalita , Santos Gilberto , Bernardo Merce , Oliveira Otávio José 
Published: May 2022

AbstractThe balanced development and management of sustainability demands the alignment of Corporate Sustainability (CS) strategy with management systems so that sustainability can be effectively inserted into all organizational levels and thus promote stakeholder engagement. Therefore, to support the development of CS, the structure, processes, indicators, and instructions of Integrated Management System (IMS) can be used. This study aims to propose guidelines for the alignment of CS and IMS, based on the cross analysis of seven case studies. This objective was achieved through the identification of elements that can positively or negatively impact the alignment of CS with the IMS, which served as the basis for proposing the guidelines to build a bridge for CS development from the IMS. This work brought as a scientific contribution the upgrade of the block of knowledge on the contributions between IMS and CS, bringing some validation of knowledge from scientific articles in the real context of industrial companies, and additions and refinements to the state of the art on the subject. In addition, the applied contribution of the results stands out, which will provide managers with a framework to intervene in organizations with structural modifications that will make them greener, socially appropriate and more profitable, thus promoting the achievement of the global goals of sustainable development proposed in Agenda 2030.
Fast Intercalation of Lithium in Semi‐Metallic γ‐GeSe Nanosheet: A New Group‐IV Monochalcogenide for Lithium‐Ion Battery Application
Authors: Shu Zheng , Cui Xiangyue , Wang Bowen , Yan Hejin , Cai Yongqing 
Published: May 2022

AbstractExistence of van der Waals gaps renders two‐dimensional (2D) materials ideal passages of lithium for being used as anode materials. However, the requirement of good conductivity significantly limits the choice of 2D candidates. So far, only graphite is satisfying due to its relatively high conductivity. Recently, a new polymorph of layered germanium selenide (γ‐GeSe) was proven to be semimetal in its bulk phase with a higher conductivity than graphite while its monolayer behaves semiconducting. In this work, by using first‐principles calculations, the possibility was investigated of using this new group‐IV monochalcogenide, γ‐GeSe, as anode in Li‐ion batteries (LIBs). The studies revealed that the Li atom would form an ionic adsorption with adjacent selenium atoms at the hollow site and exist in cationic state (lost 0.89 e to γ‐GeSe). Results of climbing image‐nudged elastic band showed the diffusion barrier of Li was 0.21 eV in the monolayer limit, which could activate a relatively fast diffusion even at room temperature on the γ‐GeSe surface. The calculated theoretical average voltages ranged from 0.071 to 0.015 V at different stoichiometry of LixGeSe with minor volume variation, suggesting its potential application as anode of LIBs. The predicted moderate binding energy, a low open‐circuit voltage (comparable to graphite), and a fast motion of Li suggested that γ‐GeSe nanosheet could be chemically exfoliated via Li intercalation and is a promising candidate as the anode material for LIBs.
Energy‐aware relay positioning in flying networks
Authors: Rodrigues Hugo , Coelho André , Ricardo Manuel , Campos Rui 
Published: May 2022

SummaryThe ability to move and hover has made rotary‐wing unmanned aerial vehicles (UAVs) suitable platforms to act as flying communications relays (FCRs), aiming at providing on‐demand, temporary wireless connectivity when there is no network infrastructure available or a need to reinforce the capacity of existing networks. However, since UAVs rely on their on‐board batteries, which can be drained quickly, they typically need to land frequently for recharging or replacing them, limiting their endurance and the flying network availability. The problem is exacerbated when a single FCR UAV is used. The FCR UAV energy is used for two main tasks: Communications and propulsion. The literature has been focused on optimizing both the flying network performance and energy efficiency from the communications point of view, overlooking the energy spent for the UAV propulsion. Yet, the energy spent for communications is typically negligible when compared with the energy spent for the UAV propulsion. In this article, we propose energy‐aware relay positioning (EREP), an algorithm for positioning the FCR taking into account the energy spent for the UAV propulsion. Building upon the conclusion that hovering is not the most energy‐efficient state, EREP defines the trajectory and speed that minimize the energy spent by the FCR UAV on propulsion, without compromising in practice the quality of service offered by the flying network. The EREP algorithm is evaluated using simulations. The obtained results show gains up to 26% in the FCR UAV endurance for negligible throughput and delay degradation.