bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the application of Bayesian estimates as part of practical problems in dependability that involve models intended for groups of homogeneous products
Authors: Khramov S. M. , Rudkovsky D. M. , Mikhailov V. M. 
Published: September 2022

. Experts in applied dependability are showing an increasing interest in the Bayesian theory. However, the Bayesian approach is not generally accepted by mathematical statistics and dependability researchers. The doubts about its practical applicability are primarily due to the fact that it allows for subjective probabilities. In practice, homogeneous product models are normally considered, i.e., each item in the evaluated batch is characterized by the same selected dependability value. In the case of Bayesian statistical estimation, the model involves heterogeneous products, however, in the course of steady production, it is not considered normal to manufacture products with varied dependability, which calls into question the adequacy of Bayesian statistical estimation methods. Aim. It is demonstrated that using Bayesian estimators that employ models designed for homogeneous products in dependability is erroneous. Methods of research. For the purpose of finding effective estimates within a selected class, integral numerical characteristics of the accuracy of estimation were used, namely, total squared bias of the expected implementation of a certain variant estimate from the examined parameters of the distribution laws, etc. Conclusions. 1. For any result, the realizations of Bayesian estimates are grouped within the dogma of mean – ≈pα = 1 – α / (α + β), while classical ≈Р2 = 1 – R/N and integral ≈Р4 unbiased estimates respond adequately to any external changes. The use of Bayesian estimates in dependability, when models designed for homogeneous products are employed, is erroneous, and there is no need to use them. 2. Bayesian estimates should only be used for groups of heterogeneous products. 3. Instead of Bayesian estimates, integral biased estimates should be used in dependability, when models designed for homogeneous products are employed.
Using the Bayes estimator for Weibull parameters estimation taking into account left-truncated and rightcensored data
Authors: Nikolaev D. A. , Antonov A. V. , Chepurko V. A. 
Published: September 2022

Today, when operation of commercial plants is organised, they are expected to comply to constantly increasing requirements for safety, dependability and efficiency of operation. The methods and procedures that are employed for the purpose of improving the safety and dependability of commercial plants are based on the information on the dependability of components, systems and equipment. In order to identify the objective dependability characteristics of such facilities, their behaviour in operation is monitored. In the course of facility operation monitoring, periods of continuous fault-free operation, periods of downtime, causes of downtime, failures, defects and malfunctions of items, frequency and depth of preventive maintenance of elements and systems, as well as other information are recorded. It should be noted that elements and systems of today’s industrial facilities, such as nuclear power plants, petrochemical complexes, etc., are classified as highly dependable equipment. Failures of such equipment are rare. The number of same-type facilities is extremely small. Aim. Given the above, the problem arises of developing methods for reliable estimation if item dependability characteristics on the basis of limited statistical information. Method. The paper examines a method for calculating facility dependability indicators on the basis of statistical information obtained in operation, i.e. a method for minimising the risk function while taking into account left-truncated and right-censored data for the purpose of Weibull distribution parameter estimation. Conclusions. By way of example, the authors refer to a method for evaluating dependability indicators based on complete, right-censored and left-truncated operation times, as, in practice, such combination is quite common. The form of likelihood functions for the Weibull distribution is given. A test case is examined, whereas, using the risk function minimisation, estimates of the Weibull distribution parameters are obtained for a sample that contains full, left-truncated and right-censored data. The authors examined the variation in the Weibull distribution values and their accuracy depending on the proportion of truncated and censored data.
Circular RNA Involvement in Aging and Longevity
Authors: Liu Jia , Niu Ruize 
Published: September 2022

Background:
Circular RNAs (circRNAs) are transcribed by RNA polymerase II and are
mostly generated by the back-splicing of exons in the protein-coding gene. Massive circRNAs are reported
to be differentially expressed in different species, implicating their prospects as aging biomarkers
or regulators in the aging progression.

Methods:
The possible role of circRNAs in aging and longevity was reviewed by the query of circRNAs
from literature reports related to tissue, organ or cellular senescence, and individual longevity.

Results:
A number of circRNAs have been found to positively and negatively modulate aging and
longevity through canonical aging pathways in the invertebrates Caenorhabditis elegans and Drosophila.
Recent studies have also shown that circRNAs regulate age-related processes and pathologies
such various mammalian tissues, as the brain, serum, heart, and muscle. Besides, three identified representative
circRNAs (circSfl, circGRIA1, and circNF1-419) were elucidated to correlate with aging
and longevity.

Conclusions:
This review outlined the current studies of circRNAs in aging and longevity, highlighting
the role of circRNAs as a biomarker of aging and as a regulator of longevity.
Epileptic Targets and Drugs: A Mini-Review
Authors: Scotti Luciana , Rodrigues Teresa Carolliny Moreira Lustoza , de Moura Jéssica Paiva , dos Santos Aline Matilde Ferreira , Monteiro Alex France M. , Lopes Simone Mendes , Scotti Marcus Tullius 
Published: September 2022

Background:
Epilepsy is a neurological disease affected by an imbalance of inhibitory and excitatory signaling in the brain.

Introduction:
In this disease, the targets are active in pathophysiology and thus can be used as a focus for pharmacological treatment.

Methods:
Several studies demonstrated the antiepileptic effect of drugs acting on the following tar-gets: N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, voltage-gated calcium channel (Cav), Gamma aminobutyric acid transporter type 1 (GAT1), voltage-gated sodium channels (Nav), voltage-gated potassium channel of the Q subfam-ily (KCNQ) and Gamma aminobutyric acid type A (GABAA) receiver.

Results:
These studies highlight the importance of molecular docking.

Conclusion:
Quantitative Structure-Activity Relationship (QSAR) and computer aided drug design (CADD) in predicting of possible pharmacological activities of these targets.
Palliative Home Visit Intervention and Emergency Admission in Pediatric
Cancer Children: A Randomized Controlled Trial
Authors: Andriastuti Murti , Halim Pricilia Gunawan , Mulyati Tati , Bangun Meidiana , Widodo Dwi Putro 
Published: September 2022

Abstract:
Palliative care model can be carried out at home, in the community, or in long-term home care. Home visits in palliative care have an important role in providing continuity of care and psychosocial support to both the patient and their parents/caretakers. This study is aimed to determine the impact of home visit program to the frequency of emergency room (ER) admissions in children with cancer.

Methods:
Randomized controlled trial of 60 pediatric patients with malignancies who were given palliative care (a 3-months home visit) and those who were not was conducted. Patients were children with cancer aged 2-18 years old. Emergency room admissions from the last three months were recorded before patients were enrolled. A two-way communication between a trained health worker and patients with or without their parents were conducted as the intervention. Interventions were given in six sessions (1 session every 2 weeks). During study period, ER admissions were recorded further. Data was analyzed using bivariate analysis, OR calculations were performed.

Results:
In the intervention group, 11 children (36.7%) had fewer ER admissions, while 4 (13.3%) had more and 15 children (50%) had constant ER admissions, respectively. Meanwhile, only 2 children (7.7%) were found to have fewer ER admissions in the control group. Others in this group have varying results, 11 children (42.3%) were found to have more admissions to the ER and 13 children (50%) had constant ER admissions. In the intervention group, ER admissions were reduced by 10 visits, while in the control group, the admissions were increased by 16 visits (OR 4.77, 95% CI 1.29-17.65; p=0.018).

Conclusion:
Palliative home visit provides care matched to patient and family needs, trained parents to be skillful in managing child, and enabling avoidance of unnecessary hospitalizations (4.7 times).
Molecular Epidemiology and Recycling of Staphylococcus aureus Resistant to Methicillin Among the Staff, Patients, and Surfaces in University Hospital in West Iran, Ilam
Authors: Taherikalani Morovat , Ghanbari Fatemeh , Nourmoradi Heshmatollah , Nazari Ali , Sadeghifard Nourkhoda , Pakzad Iraj , Soroush Setareh , Ashrafi Behnam 
Published: September 2022

Abstract:Staphylococcus aureus is a human pathogen causing nosocomial infections and increased hospitalization and mortality among human communities. Methicillin-resistant S. aureus strains are considered a severe threat in nosocomial infections and cause complications in the remedy process of bacterial infections. In this study, 137 samples were collected from different departments, staff, and patients in Ilam hospital. Eighty-eight samples of these strains were examined to test antibiotic resistance and diffusion. MIC (minimum inhibitory concentration) and PCR (polymerase chain reaction) were performed on the samples resistant to oxacillin. 36 (40.9%) strains were MRSA, and 52 (59.1%) isolates were MSSA. 44.4% of MRSA strains with IV SCCmec type. Fourteen different spa types were found using spa typing, of which the most abundant types were t037, t030, and t701, and three new types, including t15471, t15474, and t17470, were identified among the strains. The molecular analysis by MLST showed that the strains are classified into 11 different sequence types. Sequence type 239 and clonal complexes of 329 and 22 were dominant. ST239-spat037-SCCmec III was also identified as the most frequent clone of MRSA. The most identified clones were MRSA ST239-spa t037-SCCmec III. The results show the spa-type distribution between samples of patients, personnel, and surfaces, demonstrating MRSA circulation between patients and the environment. The results show the need to control environmental health
Bisphenol A-Induced Endocrine Dysfunction and its Associated Metabolic Disorders
Authors: Maniradhan Meenu , Calivarathan Latchoumycandane 
Published: September 2022

Abstract:Abstract: Bisphenol A (BPA) is an endocrine-disrupting chemical widely present in many consumer goods that poses a significant threat to our health upon exposure. Humans are exposed to BPA, which directly or indirectly causes endocrine dysfunctions that lead to metabolic disorders like obesity, fatty liver diseases, insulin resistance, polycystic ovarian syndrome, and other endocrine-related imbalances. The duration, quantity, and period of exposure to BPA, especially during the critical stage of development, determine its impact on reproductive and non-reproductive health. Because of its endocrine-disrupting effects, the European Chemical Agency has added BPA to the candidate list of chemicals of very high concern. Due to its estrogenic properties and structural similarities with thyroid hormones, BPA disrupts the endocrine system at different levels. It interacts with estrogen receptors at the molecular level and acts as an antagonist or agonist via an estrogen receptor-dependent signaling pathway. In particular, BPA binds to G-protein coupled receptors and estrogen receptors, activating signaling pathways that influence cellular apoptosis, proliferation, differentiation, and inflammation. BPA acts as an obesogen that promotes adipogenesis and correlates with increased lipid accumulation and elevated expression of adipogenic markers. As a metabolic and endocrine disruptor, BPA impairs cellular homeostasis by increasing oxidative mediators and decreasing antioxidant enzymes, resulting in mitochondrial dysfunction. Due to its endocrine-disrupting properties, BPA exposure induces endocrine dysfunctions, causing metabolic syndrome. This review gives a recent development and novel insights into the cellular and molecular mechanisms of BPA-induced endocrine dysfunctions and their associated metabolic disorders.
The Relationship between Serum Iron and Thyroid Function in the Patients
with Type 2 Diabetes
Authors: Wang Congcong , Wen Song , Yuan Xinlu , Zhou Mingyue , Li Yanyan , Gong Min , Jin Jianlan , Zhou Ligang 
Published: September 2022

Purpose:
Our primary objective in this study is to determine the relationship
between serum iron (Fe3+) and thyroid functions in type 2 diabetes mellitus (T2DM) patients.

Materials and Methods:
Glucose metabolic parameters, trace elements, such as Fe3+, and
thyroid functions for 1657 type 2 diabetic patients treated at the Shanghai Pudong Hospital's
Department of Endocrinology from 2018 to 2021 were assessed.

Results:
Variations in free thyroid hormones (FTH) and total thyroid hormones (TTH)
were insignificant; however, thyroid-stimulating hormone (TSH) levels were markedly
elevated in patients with positive thyroid peroxidase antibody (TPOAb) and/or positive
antithyroglobulin antibody (TgAb) (p<0.05). Additionally, gender disparities affected
FTH levels (p<0.05) but not TTH and TSH levels. The female gender was significantly
negatively correlated with serum Fe levels (r=-0.381, p<0.05). Serum Fe3+ deficiency
also had an effect on FT3 in both genders, FT4 and TT4 in males (p<0.05), but not TSH
(p>0.05). The multilinear regression model showed that TT3 (β=0.702), eGFR
(β=0.109), Fe3+ (β=0.003), female gender (β=-0.061), and age (β=-0.061) were the major
determinants for FT3 change. Moreover, renal function, which was represented as the
estimated glomerular filtration rate (eGFR), had no effects on Fe3+ and TSH levels but on
the levels of FTH and TTH (p<0.05). FT3/FT4 exhibited correlations with Fe3+ (r=0.252)
and eGFR (r=0.285). Finally, changes in Fe3+ levels had no significant impact on fasting
plasma glucose (FPG), fasting C-peptide, HbA1c, and glycated albumin levels (p>0.05).

Conclusions:
In addition to age, gender, and renal functions, serum Fe3+ levels in T2DM
patients have a significant relationship with thyroid functions.
MicroRNAs as a New Target for Alzheimer's Disease Treatment
Authors: Shademan Behrouz , Avci Cigir Biray , Karamad Vahidreza , Sogutlu Fatma , Nourazarian Alireza 
Published: September 2022

Abstract:
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease associated with advanced age. It is characterized by cognitive decline and memory loss and accounts for most cases of dementia in older people. AD can be rooted in genetic, epigenetic, or environmental causes. There are no drugs or other therapeutic agents to prevent or delay AD progression. MicroRNAs (miRNAs) are short and uncoded RNAs that can bind to 200 RNAs approximately. By inhibiting or destroying specific messenger RNAs (mRNAs), they control gene expression and broadly affect cellular functions. MiRNAs play important roles in regulating neuronal growth, neuronal differentiation, dendritic spine morphology, and synaptic flexibility in the nervous system. The expression levels of miRNAs are changed in neurological diseases, including AD, suggesting that they play an essential role in the pathogenesis of the disease. Therefore, targeting disrupted miRNAs may be a novel therapeutic approach against AD and offers multiple solutions, including harnessing the beneficial effects of beta-amyloid, reducing tau protein, reducing neuronal cell death, and protecting synapses in AD.
A Systematic Review on Sesamum indicum L.: Bridging Traditional
Information and Pharmacological Indications for Future Translational
Research
Authors: Chandra Phool , Shivam  , Sachan Neetu 
Published: September 2022

Background::
Sesame (Sesamum indicum L., family: Pedaleaceae) is also known as Til, sesamum, beniseed, and sim-sim. Sesame is an herbaceous, tropical, erect, annually grown, and oldest oilseed plant. Sesame crop has been mainly cultivated in Asia, Africa, and different parts of the world for centuries.

Objective:
The aim of this systematic review on Sesamum indicum L is to bridge traditional information and pharmacological indications for future translational research.

Methods:
The current study of Sesamum indicum (S. indicum) on its phytochemistry, pharmacological activities, and customary uses depends on a few well-known databases, for example, ACS, Web of Science, PubMed, Scopus, Science Direct, SciFinder, Google Scholar, Wiley online library, Springer, Taylor and Francis, Pubmed, and other distributed materials, for example, course books and papers. The literature was looked at using the catchphrases ‘Sesamum indicum’ Sesamin, Sesamol, and Sesamolin, etc.

Results:
Based on data found during reviews, sesame possesses numerous traditional uses and activities. It also showed that different parts of the plant contain different phytoconstituents.

Conclusion:
Conclusively, it is found that S. indicum has been confirmed as an essential therapeutic origin from its conventional use.
The Use of Compression Stockings to Reduce Water Retention in the Legs During Gaming and Esports: Randomized Controlled Field Study
Authors: Schmidt Steffen Christian Ekkehard , Sell Stefan , Woll Alexander 
Published: September 2022

Background
With the increasing digitalization of daily life, internet-based entertainment such as gaming and streaming has advanced to one of the megatrends of the 21st century. Besides offering a multitude of controversially discussed opportunities for entertainment and social interaction, there is reasonable concern about health issues caused by the absence of physical activity among activities linked to gaming and streaming.

Objective
The aim of this study is to compare the water balance of recreational gamers with and those without compression stockings during a gaming event.

Methods
We measured body composition and water balance with 8-electrode bioelectrical impedance analysis among 46 recreational gamers with an average age of 27.1 (SD 6.5) years (5/46, 11% women and 41/46, 89% men) before and after 24 hours at a gaming event. Of the 46 gamers, 23 (50%) gamers wore compression stockings for the duration of the study.

Results
Our study shows that prolonged gaming and associated behaviors during a 24-hour time frame lead to an increase in total body water (+0.76 L; P<.001) and a decrease of phase angle in the lower extremities (−0.47°; P<.001) but not in the upper extremities (+0.09°; P=.80), when no compression is used. Gamers using compression socks did not show any significant negative effects on their body composition.

Conclusions
Prolonged gaming and streaming are serious risk factors for diseases associated with water retention in the legs, and these risks can be measured by bioelectrical impedance and reduced by wearing compression stockings. We conclude that these findings should be discussed and replicated in larger studies and that there is a considerably large market for compression stockings among gamers and live streamers.
Programas de prevención para trastornos alimentarios y factores asociados en México: una revisión sistemática/Prevention programs for eating disorders and associated factors in Mexico: a systematic review
Authors: Cueto-López Carmen Julia , González Díaz Frida Itzel , Franco-Paredes Karina 
Published: September 2022

El objetivo de esta investigación fue revisar sistemáticamente los estudios realizados en México sobre programas de prevención para los trastornos de la conducta alimentaria y de la ingesta de alimentos (TAIA) y sus variables asociadas. La investigación se realizó considerando las directrices de la Declaración PRISMA e incluyó estudios publicados entre el año 2006 y 2020. La búsqueda se realizó en las bases de datos EBSCO, WILEY, Scopus, Dialnet, Redalyc, Taylor & Francis, Scielo y el buscador Google académico, utilizando los términos “trastorno de la conducta alimentaria” OR “trastornos alimentarios” AND “intervención” OR “prevención” AND “México” y en inglés los términos equivalentes fueron "Eating disorder" AND "intervention" OR "prevention" AND "Mexico". Se encontraron 12 artículos, ocho (67%) se enfocaron a la prevención primaria selectiva (muestra entre 15 y 58 participantes), principalmente dirigidos a mujeres adolescentes (75%). Se identificaron cuatro estudios (33%) sobre prevención primaria (muestra entre 120 y 388 participantes) en varones, mujeres adolescentes y adultos jóvenes. La mayoría de los estudio (67%) utilizó la psicoeducación, y las estrategias cognitivo-conductuales (58%). En general, se encontraron resultados positivos sobre los niveles de insatisfacción corporal, la preocupación por el peso y la comida y la conducta alimentaria compulsiva. Se concluye que es necesario aumentar en México la producción de investigaciones sobre programas preventivos de TAIA y sus factores asociados, así como generar evidencias sólidas de los resultados de la intervención.
PENGARUH PERUBAHAN VISKOSITAS ASPAL AKIBAT PENAMBAHAN VIATOP66 TERHADAP NILAI TEGANGAN TARIK (TENSILE STRENGTH) CAMPURAN HRS-WC MENGGUNAKAN UJI SEMI CIRCULAR BENDING (SCB)
Authors: Erikasari Yodya 
Published: September 2022

Penggunaan bahan tambah berupa viatop66 ke dalam campuran Hot Rolled Sheet-Wearing Course (HRS-WC) diharapkan dapat meningkatkan nilai tegangan tarik maksimum yang dapat dipikul oleh suatu perkerasan. Viatop66 juga diduga dapat mempengaruhi nilai viskositas aspal sehingga dapat meningkatkan kualitas perkerasan jalan. Tujuan penelitian ini untuk mengetahui pengaruh perubahan nilai viskositas aspal akibat penggunaan bahan tambah viatop66 terhadap nilai tegangan tarik maksimum campuran HRS-WC. Metode pengujian yang digunakan adalah metode uji semi circular bending (SCB). Aspal yang digunakan untuk campuran HRS-WC ditambahkan dengan variasi kadar viatop66 sebesar 0,0% ; 0,1%; 0,2%; 0,3%; 0,4%; dan 0,5%. Hasil penelitian menunjukkan bahwa peningkatan nilai viskositas aspal akibat penggunaan bahan tambah viatop66 dapat meningkatkan suhu pemadatan dan meningkatkan nilai tegangan tarik maksimum campuran HRS-WC. Suhu pemadatan yang meningkat serta serat-serat yang terkandung dalam viatop66 dapat mengisi rongga-rongga antar agregat sehingga campuran semakin padat dan dapat meningkatkan nilai stabilitas dan nilai tegangan tarik campuran HRS-WC. Untuk penambahan viatop66 0% - 0,5% persentase kenaikan viskositas aspal sebesar 0,3% ; 0,5% ; 0,8% ; 0,9% ; dan 1,1% dengan persentase kenaikan nilai tegangan tarik campuran HRS-WC sebesar 0,23% ; 0,28% ; 0,31% ; 0,35% ; dan 0,43%.