bluuebunny/crossref_metadata_2025_split huggingface dataset:
Home Blood Pressure in Target Range as an Additional Therapeutic Goal in Hypertensive Patients. Telemonitoring-based Analysis.
Authors: Ionov Mikhail , Usova Elena , Egorov Michil , Zvartau Nadezhda , Konradi Alexandra 
Published: July 2022

Abstract
Aim
Guidelines recommend treating hypertension (HTN) keeping office blood pressure (BP) within the therapeutic range (TR) rather than aiming to achieve only cut-off value. Time of office BP values in TR is an independent predictor of cardiovascular events. However, data on home BP in TR are lacking. Telehealth simplify collection and structure home BP. We aim to find reliable proportion of home systolic (S) BP in TR (sBPiTR) and to evaluate its impact on overall BP control.
Methods
We used the data of HTN patients who participated in BP telemonitoring and counseling for 3 months. We divided sBPiTR (110–130 mmHg, all SBP readings except the very or every 1st day) by quartiles (< 25; 25 to 49; 50 to 74; >74). A weighted Cohen's kappa coefficient was an estimate of inter-rater reliability between sBPiTR and office SBP or home SBP in TR at 3 months. We used binomial logistic regression to evaluate the predictive value of sBPiTR on target office/home SBP achievement.
Results
A total of 123 patients were included (median age 54 years; 102 males) with a median office SBP of 140 mmHg. By 3 months it decreased to 130 mmHg (p < 0.001), and 60.2% patients achieved a target of 120–139 mmHg. More patients were in the upper sBPiTR quartiles (70% versus 30%). There was a slight agreement between office SBP in TR and sBPiTR ≥ 50% (k = 0.19, p < 0.035). The reliability increased when countered against home SBP in TR (k = 0.32–0.65], p < 0.0001). Patients with sBPiTR ≥ 50% were more likely to fall within office SBP TR (OR 2.41, 95% CI [1.06 to 5.51] and home SBP TR (OR 5.2 95% CI [2.06–13.12] after adjustment for baseline covariates.
Conclusion
The threshold of 50% of home SBP measurements within 110–130 mmHg has a slight agreement with office BP control and a fair agreement with home BP control. This variable may serve a predictor for achievement of target SBP both for in- and out-of office. Larger studies are needed to confirm these preliminary results.
Sistem Informasi Inventory Bahan Baku Dan Barang Menggunakan Metode FIFO Studi Kasus Sinergi Co-Working
Authors: Lefrandy Pradana Alfonsius , Wijana Katon , Sutedjo Budi 
Published: July 2022

Sinergi Co-Working a place that is a collaboration of a workspace and cafe, which is located at Jl. Cendrawasih No.32b, Demangan, Yogyakarta. All inventory recording activities at this cafe are still being done manually. Starting from recording the incoming and outgoing raw materials and goods. As a result, the inventory flow is not good enough to cause inventory to become damaged or production failure. Users who can access bookkeeping are many. This also results in frequent errors in recording, reports that are not detailed or lacking and inventory becomes obstructed and accumulation occurs in the warehouse. The research objective was to create an inventory system for raw materials and goods using the First In First Out method to answer and solve problems that occurred. This research makes inventory recording better and more systematic so that the operational flow of materials and goods is always fresh. Using such a system improves the flow of inventory. And a good display will help employees or users increase their knowledge of product knowledge. The inventory system that has been successfully built was tested on 10 respondents with 11% less agreeable results. The system is needed, but it is still considered lacking by respondents. In the inventory flow that will be in the actual field. It could be that the system runs well but in the field, it doesn't, due to employee negligence. Then the biggest result is Agree 49%. The inventory system is correct and appropriate to answer all existing problems.
Modelling of aerobic granular sludge reactors: the importance of hydrodynamic regimes, selective sludge removal and gradients
Authors: Derlon Nicolas , Garcia Villodres Mercedes , Kovács Róbert , Brison Antoine , Layer Manuel , Takács Imre , Morgenroth Eberhard 
Published: July 2022

Abstract
Hydraulic selection is a key feature of aerobic granular sludge (AGS) systems but existing aerobic granular sludge (AGS) models neglect those mechanisms: gradients over reactor height (Hreactor), selective removal of slow settling sludge, etc. This study aimed at evaluating to what extent integration of those additional processes into AGS models is needed, i.e., at demonstrating that model predictions (biomass inventory, microbial activities and effluent quality) are affected by such additional model complexity. We therefore developed a new AGS model that includes key features of full-scale AGS systems: fill-draw operation, selective sludge removal, distinct settling models for flocs/granules. We then compared predictions of our model to those of a fully mixed AGS model. Our results demonstrate that hydraulic selection can be predicted with an assembly of four continuous stirred tank reactors in series together with a correction code for plug-flow. Concentration gradients over the reactor height during settling/plug-flow feeding strongly impact the predictions of aerobic granular sludge models in terms of microbial selection, microbial activities and ultimately effluent quality. Hydraulic selection is a key to predict selection of storing microorganisms (phosphorus-accumulating organisms (PAO) and glycogen-accumulating organisms (GAO)) and in turn effluent quality in terms of total phosphorus, and for predicting effluent solid concentration and dynamic during plug-flow feeding.
Copper removal from aqueous solution using chemical precipitation and adsorption by Himalayan Pine Forest Residue as Biochar
Authors: Bashir Misbah , Mohan Chander , Tyagi Shivani , Annachhatre Ajit 
Published: July 2022

Abstract
This research deals with the use of pine residue biochar as an adsorbent for the removal of copper from aqueous solution which is a major component of printed circuit boards from E-waste. Biochar was produced from pine residue such as bark, cone and needle through pyrolysis, and the effect of temperature on biochar properties was assessed. The biochar yield of about 33% and maximum surface area of 368 m2/g was obtained at pyrolysis temperature of 650°C. FTIR analysis revealed the existence of C-O, O-H and C = C functional groups on the surface of biochars. The point of zero charge of pine biochars were in the range 5.55 to 5.75. Batch adsorption studies revealed maximum copper adsorption capacity of 60–81 mg/g at near neutral pH. The batch adsorption data fitted well with Langmuir isotherm and followed the pseudo-second order kinetics. Adsorption of copper onto the biochar surface mainly followed physisorption which was reversible in nature. Desorption study revealed that pine biochar could be reused up to three cycles. Column adsorption data fitted well with Thomas model. These investigations revealed that the pine residue, which otherwise results in adverse environmental impacts, can be converted into useful resource like biochar as a heavy metal adsorbent.
Hsa_circ_0008092 Contributes to Cell Proliferation and Metastasis in
Hepatocellular Carcinoma via the miR-502-5p/CCND1 Axis
Authors: Maimaiti Yilihamu , Kamali Aihesan , Yang Peng , Zhong Kai , Abuduhadeer Xiaokaiti 
Published: July 2022

Background:
The present study was targeted at investigating the effects of
hsa_circRNA_0008092 (circ_0008092) on hepatocellular carcinoma (HCC) cell proliferation,
migration, invasion and apoptosis, and its related mechanism.

Methods:
The gene expression profiles of GSE166678 were downloaded from the Gene Expression
Omnibus database, and differentially expressed circRNAs in human HCC were screened out.
Besides, circ_0008092, microRNA-502-5p (miR-502-5p) and cyclin D1 (CCND1) expressions in
HCC tissues and cell lines were detected by quantitative real-time polymerase chain reaction (qRTPCR).
Cell countering kit-8 (CCK-8), Transwell and flow cytometry assays were used to detect the
proliferation, migration, invasion and apoptosis of HCC cells. Bioinformatics was utilized to predict
the targeted relationships between miR-502-5p and circ_0008092, as well as miR-502-5p and
CCND1 mRNA 3'-untranslated region (3’UTR). Western blot assay was applied to detect CCND1
protein expression in HCC cells.

Results:
Circ_0008092 was highly expressed in HCC tissues and cells, which was associated with a
shorter survival time in patients with HCC. Circ_0008092 overexpression promoted proliferation,
migration and invasion, and inhibited apoptosis of HCC cells; circ_0008092 knockdown worked
oppositely. Circ_0008092 directly targeted miR-502-5p and negatively modulated miR-502-5p
expression. CCND1 was a target gene of miR-502-5p, and was positively and indirectly modulated
by circ_0008092.

Conclusions:
Our data suggest that circ_0008092 promotes HCC progression by regulating the miR-
502-5p/CCND1 axis.
Systematic Review of the Frequency of Registered Dietitian-Nutritionist
Intervention in the Primary Care Setting for Diabetes Self-Management
Education for Patients with Type II Diabetes
Authors: Henderson Dana , Salmons Hannah , Winston Paris , Koehn Deborah A. 
Published: July 2022

Purpose:
The purpose of this systematic review is to discuss the ideal frequency of Registered
Dietitian-Nutritionist (RDN) contact required to improve glycemic control in patients with
type 2 diabetes in the primary care setting.

Methods:
Researchers completed a literature search between April 1 and June 30, 2020. Researchers
identified 184 studies and included seven studies for full-text analysis. Eligible studies
were required to occur in a primary care setting, use A1C as an outcome measure, and use some
form of education or contact with an RDN. Study quality was assessed using the NIH Study Quality
Assessment Tool.

Results:
Compared to the usual care group of each study, increased contact with an RDN improved
A1C lowering regardless of frequency (round-the-clock, monthly, biannually). The largest decreases
occurred in the round-the-clockand quarterly touch groups. Studies varied in modality (inperson,
telehealth, etc.) and type of intervention. The participants had A1Cs between 8.07% and
10.25% before intervention. With RDN contact of any frequency between provider visits and participants
saw A1Cs decreased between 0.66% and 2.2%.

Conclusion:
Greater glycemic control in patients with type 2 diabetes in the primary care environment
is linked to more frequent RDN contact than that advised by the American Diabetes Association
Standards of Care.
Computational Simulation of Atherosclerosis Progression Associated with Blood Pressure in a 2-D Idealized Human Carotid Artery Model
Authors: Alagbe Edith E. , Amoo Temiloluwa E. , Ayeni Augustine O. , Oyedele Oluwakayode S. , Ashiekaa Vershima D. 
Published: July 2022

Introduction:
Cardiovascular diseases are a known health threat with no respect for age. The need to understand the initiation and progress of the disease is expedient in proper diagnosis and management of the disease.

Objective:
The work is targeted at simulating the effect of elevated blood pressure on the initiation and development of plaque over time concerning wall shear stress, WSS and plaque wall stress, and PWS.

Methods:
Conditions such as blood velocity, pressure, and arterial wall conditions associated with blood flow in arteries, as well as patient-specific characterization related to these variables and conditions, were plugged into modified models in the COMSOL multiphysics software. The artery was modeled as an idealized 2-D carotid artery model.

Results:
Results showed that the WSS distribution with respect to changes with a blood pressure of 500 Pa gave the highest WSS value at the plaque neck and 1500 Pa gave the highest WSS value in the regions close to the plaque root. It was also observed that as the plaque size increased, the region experiencing severely high values for WSS also expanded.

Conclusion:
It can be recommended that blood pressure monitoring is necessary to curb the attendant cardiovascular diseases associated with high blood pressure.
Analysing the Social Responsibility among Dentists of Ethiopia: A Cross-sectional Study
Authors: Rai Archana , Rai Vineet , Berhanu Tizeta 
Published: July 2022

Objective:
Dentistry is essentially a business at present. The present study aimed to analyze the meaning and implications of social responsibility among the dentists of Ethiopia. It further evaluated whether the dental professionals of Ethiopia consider themselves as responsible for equitable distribution of dental care.

Materials and Methods:
This cross-sectional study was conducted on 200 dentists practicing in Addis Ababa and Jimma city of Ethiopia in the academic year 2017-18. Simple random sampling technique was used to collect the required sample. The results were recorded by filling the predesigned self-administered questionnaire by the dentists. The descriptive statistics and cross-tabulation were used for data analysis using the software SPSS version 20.

Results:
Among 200 dentists, 168 dentists (which make up 84% of the sample of 200 dentists) considered finance as a major barrier to accessing dental health care in Ethiopia. Further, 168 (84% of the sample) said that the meaning of social responsibility in the dental profession was providing better access to dental care to those who are underserved. All of the participants (100%) who lived in Addis Ababa and 92% of participants of Jimma thought that social responsibility should be taught as a part of public health dentistry.

Conclusion:
Dentists were aware of their responsibilities in terms of providing better access to dental care to those who are underserved, but most of them considered finance as the major barrier. So, they looked at dentistry primarily as a business. This shows not only dentists working in the dental profession are socially liable for guaranteeing fair admittance to dental care, but the society and government are also responsible for its proper implementation.
Integrating Natural Language Processing and Interpretive Thematic Analyses to Gain Human-Centered Design Insights on HIV Mobile Health: Proof-of-Concept Analysis
Authors: Skeen Simone J , Jones Stephen Scott , Cruse Carolyn Marie , Horvath Keith J 
Published: July 2022

BackgroundHIV mobile health (mHealth) interventions often incorporate interactive peer-to-peer features. The user-generated content (UGC) created by these features can offer valuable design insights by revealing what topics and life events are most salient for participants, which can serve as targets for subsequent interventions. However, unstructured, textual UGC can be difficult to analyze. Interpretive thematic analyses can preserve rich narratives and latent themes but are labor-intensive and therefore scale poorly. Natural language processing (NLP) methods scale more readily but often produce only coarse descriptive results. Recent calls to advance the field have emphasized the untapped potential of combined NLP and qualitative analyses toward advancing user attunement in next-generation mHealth.ObjectiveIn this proof-of-concept analysis, we gain human-centered design insights by applying hybrid consecutive NLP-qualitative methods to UGC from an HIV mHealth forum.MethodsUGC was extracted from Thrive With Me, a web app intervention for men living with HIV that includes an unstructured peer-to-peer support forum. In Python, topics were modeled by latent Dirichlet allocation. Rule-based sentiment analysis scored interactions by emotional valence. Using a novel ranking standard, the experientially richest and most emotionally polarized segments of UGC were condensed and then analyzed thematically in Dedoose. Design insights were then distilled from these themes.ResultsThe refined topic model detected K=3 topics: A: disease coping; B: social adversities; C: salutations and check-ins. Strong intratopic themes included HIV medication adherence, survivorship, and relationship challenges. Negative UGC often involved strong negative reactions to external media events. Positive UGC often focused on gratitude for survival, well-being, and fellow users’ support.ConclusionsWith routinization, hybrid NLP-qualitative methods may be viable to rapidly characterize UGC in mHealth environments. Design principles point toward opportunities to align mHealth intervention features with the organically occurring uses captured in these analyses, for example, by foregrounding inspiring personal narratives and expressions of gratitude, or de-emphasizing anger-inducing media.
An Isoenergetic Multifactorial Diet Reduces Pancreatic Fat and Increases Postprandial Insulin Response in Patients With Type 2 Diabetes: A Randomized Controlled Trial
Authors: Della Pepa Giuseppe , Brancato Valentina , Costabile Giuseppina , Salamone Dominic , Corrado Alessandra , Vitale Marilena , Cavaliere Carlo , Mancini Marcello , Salvatore Marco , Luongo Delia , Riccardi Gabriele , Rivellese Angela A. , Annuzzi Giovanni , Bozzetto Lutgarda 
Published: July 2022

OBJECTIVE
To compare the effect of an isocaloric multifactorial diet with a diet rich in monounsaturated fatty acids (MUFA) and similar macronutrient composition on pancreatic fat (PF) and postprandial insulin response in type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS
According to a randomized controlled parallel-group design, 39 individuals with T2D, 35–75 years old, in satisfactory blood glucose control, were assigned to an 8 week isocaloric intervention with a multifactorial diet rich in MUFA, polyunsaturated fatty acids, fiber, polyphenols, and vitamins (n = 18) or a MUFA-rich diet (n = 21). Before/after the intervention, PF content was measured by the proton-density fat fraction using a three-dimensional mDIXON MRI sequence, and plasma insulin and glucose concentrations were measured over a 4 h test meal with a similar composition as the assigned diet.

RESULTS
After 8 weeks, PF significantly decreased after the multifactorial diet (from 15.7 ± 6.5% to 14.1 ± 6.3%; P = 0.024), while it did not change after the MUFA diet (from 17.1 ± 10.1% to 18.6 ± 10.6%; P = 0.139) with a significant difference between diets (P = 0.014). Postprandial glucose response was similar in the two groups. Early postprandial insulin response (incremental postprandial areas under the curve [iAUC0–120]) significantly increased with the multifactorial diet (from 36,340 ± 34,954 to 44,138 ± 31,878 pmol/L/min; P = 0.037), while it did not change significantly in the MUFA diet (from 31,754 ± 18,446 to 26,976 ± 12,265 pmol/L/min; P = 0.178), with a significant difference between diets (P = 0.023). Changes in PF inversely correlated with changes in early postprandial insulin response (r = −0.383; P = 0.023).

CONCLUSIONS
In patients with T2D, an isocaloric multifactorial diet, including several beneficial dietary components, markedly reduced PF. This reduction was associated with an improved postprandial insulin response.
An isoenergetic multifactorial diet reduces pancreatic fat and increases postprandial insulin response in patients with type 2 diabetes: a randomized controlled trial
Authors: Pepa Giuseppe Della , Brancato Valentina , Costabile Giuseppina , Salamone Dominic , Corrado Alessandra , Vitale Marilena , Cavaliere Carlo , Mancini Marcello , Salvatore Marco , Luongo Delia , Riccardi Gabriele , Rivellese Angela A. , Annuzzi Giovanni , Bozzetto Lutgarda 
Published: July 2022

<p> </p>
<p><strong>Objective: </strong>To compare the effect of an isocaloric multifactorial diet with a diet rich in monounsaturated fatty acids (MUFA) and similar macronutrient composition on pancreatic fat (PF) and postprandial insulin response in Type 2 Diabetes (T2D).</p>
<p><strong>Research Design and Methods:</strong> According to a randomized controlled parallel group design, 39 individuals with T2D, 35–75 years-old, in satisfactory blood glucose control, were assigned to an 8-week isocaloric intervention with a multifactorial diet rich in MUFA, polyunsaturated fatty acids, fibre, polyphenols, and vitamins (n=18) or a MUFA rich diet (n=21). Before/after the intervention, PF content was measured by the proton-density fat fraction using a 3D mDixon MRI sequence, plasma insulin and glucose concentrations were measured over a 4h test-meal with a similar composition as the assigned diet. </p>
<p><strong>Results:</strong> After 8 weeks, PF significantly decreased after the multifactorial diet (from 15.7±6.5% to 14.1±6.3%, p=0.024) while it did not change after the MUFA diet (from 17.1±10.1% to 18.6±10.6%, p=0.139) with a significant difference between diets (p=0.014). Postprandial glucose response was similar in the two groups. Early postprandial insulin response (iAUC0-120) significantly increased with the multifactorial diet (from 36340±34954 to 44138±31878 pmol/L·min, p=0.037), while it did not change significantly in the MUFA diet (from 31754±18446 to 26976±12265 pmol/L·min, p=0.178), with a significant difference between diets (p=0.023). Changes in PF inversely correlated with changes in early postprandial insulin response (r=-0.383, p=0.023). </p>
<p><strong>Conclusions: </strong>In T2D patients, an isocaloric multifactorial diet including several beneficial dietary components markedly reduced PF. This reduction was associated with an improved postprandial insulin response.</p>
OPTIMIZING THE PROCESS OF RESISTANCE SPOT WELDING FOR 2014 – O ALUMINUM ALLOY SHEET
Authors: Zeidan Lutfi 
Published: July 2022

There is a strong interest in the use of aluminum alloy sheet for vehicle applications, particularly the body, where resistance spot welding is the principle joining method. The resistance spot welding (R.S.W) quality has a great effected by the process variable such as, welding current, welding time, and electrode pressure beside other variable such as material thickness and type and electrode diameter.
In this work the effect of process variable on welding quality was investigated. Trials were conducted on 1.2 mm thick 2014 – O aluminum alloy sheet. The tensile shear strength was used as primary index of welds quality. Experimental investigation show that the best current is 45 KA, best time is 10 cycle, and electrode pressure of 3 KN .
INVESTIGATION MEASUREMENT OF DISPERSION COEFFICIENT AND MIXING TIMES IN BUBBLE COLUMN
Authors: Burhan Sadeq Abdulrazzaq  
Published: July 2022

A complete model of liquid-phase dispersion was used to simultaneously characterize axial and radial mixing in bubble column of 0.15 m inside diameter and plastic plate distributor with holes of 2 mm diameter. Axial and radial dispersion coefficients and mixing times were determined in tap water for superficial gas velocities in the range 0.6-5.36 cm/s. The experiments were carried out using a transient method (the tracer response method). The dispersion coefficient was obtained by adjusting the experimental profiles of tracer concentration with the predictions of the model. The measured axial dispersion coefficients (Dax,L) were generally consistent with the predictions of the well established correlations, thus validating the complete dispersion model used in the analysis. The Dax,L values ranged from 110 to 200 cm2/s. There was evidence that the existing literature data on Dax,L in bubble columns are slightly underestimated, as consistent underestimation was found to be a characteristic of the widely used dispersion model that disregards radial dispersion. The value of the radial dispersion coefficient was typically about 1 to 2% of the Dax,L value under any given condition. The mixing time data were generally consistent with the existing literature.
The results of this study are compared with experimental result and upper bound theory and have shown a good agreement with a minimum discrepancy