bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of Tissue Oxygen Saturation in the Vastus Lateralis Muscle of Chronic Stroke Survivors During a Graded Exercise Test
Authors: Hyngstrom Allison S. , Nguyen Jennifer N. , Uhrich Toni D. , Wright Michael T. , Gutterman David D. , Schmit Brian D. , Durand Matthew J. 
Published: November 2022

Purpose:
This study examined tissue oxygen saturation (StO2) of the vastus lateralis (VL) muscles of chronic stroke survivors during a graded exercise test (GXT). We hypothesized that the reduction in StO2 will be blunted in the paretic versus nonparetic VL during a maximum effort GXT.

Methods:
Chronic stroke survivors performed a GXT, and StO2 of the VL in each leg was measured using near-infrared spectroscopy. Twenty-six stroke survivors performed a GXT.

Results:
At rest, there was no difference in StO2 between the paretic and nonparetic VL (65 ± 9% vs 68 ± 7%, respectively, P = .32). The maximum change in StO2 from rest during the GXT was greater in the nonparetic versus the paretic VL (−16 ± 14% vs −9 ± 10%, respectively, P < .001). The magnitude of the oxygen resaturation response was also greater in the nonparetic versus the paretic VL (29 ± 23% vs 18 ± 15%, respectively, P < .001). VO2 peak was associated with the magnitude of the VL StO2 change during (r2 = 0.54, P < .0001) and after (r2 = 0.56, P < .001) the GXT.

Conclusion:
During a GXT, there is a blunted oxygen desaturation response in the paretic versus the nonparetic VL of chronic stroke survivors. In the paretic VL, there was a positive correlation between the oxygen desaturation response during the GXT and VO2 peak.
Assessing Adult Patients with Facial Deformities for Injectable Treatment: Do Current Classification Systems and Methodologies Meet Important Patient Needs?
Authors: Chantrey Jonquille , Ryder Timothy J. 
Published: November 2022

BACKGROUND
Many individuals are affected by facial deformities. Injectable aesthetic treatments can often be used to improve appearance and/or dynamic function. However, to best meet the needs of these patients, broadly applicable methodologies are required for classifying the deformity, assessing severity, and developing a treatment strategy.

OBJECTIVE
To assess whether any published systems could be used for this purpose.

METHODS
Thirty-eight searches were conducted in PubMed (1999–2019; in English). Forty-two publications were identified describing novel classification systems for adult facial deformity. They were analyzed against a checklist of 10 characteristics defining an “optimal” system—based on appropriate anatomical coverage, wide usability across types of deformity, user-friendliness, applicable underlying methodology, and ability to guide treatment with injectables.

RESULTS
None of the systems met more than 7 of the 10 checklist criteria; none were usable across multiple types of deformity or provided a recommendation for treatment with injectables.

CONCLUSION
There remains a need for a broadly applicable system for classifying adult facial deformities ahead of injectable therapy. The checklist provides a developmental framework. With the increasing popularity and accessibility of injectables, this diverse and complex demographic is at risk of mismanagement without superior methods for devising treatment strategies.
Prospective Study of 532-nm Picosecond Laser for the Treatment of Pigmented Lesions of the Face and Dorsal Hands
Authors: Friedmann Daniel P. , Timmerman Alina , Cahana Zoya 
Published: November 2022

BACKGROUND
Pigmented lesions from chronic UV photoaging are extremely common on the face and hands.

OBJECTIVE
To evaluate the safety and efficacy of a 532-nm picosecond laser for these types of pigmented lesions.

METHODS
This was a single-center, prospective, open-label clinical trial. Eligible subjects with pigmentation on the face and hands received 3 monthly treatments, with 1 month (1M) and 3 months (3M) follow-up. Change in investigator-graded overall facial and per lesion pigmentation and subject-graded satisfaction and pigmentation improvement was evaluated by a 5-point scale. Immediate skin response and adverse events (AEs) were evaluated post-treatment. The melanin index was measured using a mexameter. Randomized before and after photographs were graded by 3 blinded physicians for degree of pigmentation improvement.

RESULTS
Twenty-five subjects (22F/3M) with Fitzpatrick skin types I-III were enrolled, with 23 subjects completing. Treatments used a 532 nm wavelength, 800 ps pulse duration, 4-6mm spot size, and 0.1 to 0.6J/cm2 fluence. Good-to-excellent clearance at 1M/3M was demonstrated in ≥95% of lesions (n = 116). Only mild treatment-related pain was reported, with transient post-treatment AEs (mean downtime of 2.1 ± 2.0 days) and no serious treatment-related AEs. Subject satisfaction (satisfied or very satisfied) was 95% at 1M and 91% at 3M.

CONCLUSION
Treatment with a 532-nm picosecond laser is safe and highly effective for the treatment of the pigmented lesions of the face and dorsal hands.
Physicians and healthcare professionals as advocates for abortion care and reproductive choice
Authors: Carroll Smita , Joshi Devki , Espey Eve 
Published: November 2022

Purpose of review
The current review discusses the overarching role of advocacy as a primary component of access to abortion care. Abortion is viewed differently from any other form of health care, resulting in a marginalized, but essential healthcare component: without ongoing effective and strategic advocacy, abortion will not become or remain available. Lack of access to abortion care disproportionately affects historically excluded communities.

Recent findings
Advocacy is core to the provision of sexual and reproductive health. The antiabortion community has effectively used policy to achieve long-term goals of severely restricting access to abortion. Crisis pregnancy centers, the COVID-19 pandemic, and the antiabortion legislation of 2022 have exacerbated existing health inequities. Community engagement and advocacy skills assist providers to support access and combat inequities. Provider and trainee education, interprofessional collaboration, and leadership are critical in the effort to support comprehensive reproductive health care.

Summary
Through this literature review and our lived experiences as abortion providers, we assert the importance of healthcare professionals as advocates for abortion rights and services. The need for advocacy crosses specialties and communities; together we are stronger advocates as we continue to support and fight for access to safe legal and equitable abortion care.
Inferiorly based nasolabial flap for reconstruction of full-thickness medium-sized lower lip and commissural defects following ablative cancer surgery
Authors: Tsai Chien-Sheng , Chang Chan-Chi , Hsiao Jenn-Ren 
Published: November 2022

Background:
Information regarding the design and usage of inferiorly based nasolabial flap for lower lip and commissural defect reconstruction following ablative cancer surgery remains limited. This study aimed to provide our design and experiences for such reconstructive purpose.

Methods:
Patients with lower lip or oral commissural cancer who received curative surgery involving reconstruction with inferiorly based nasolabial flap were included. The demographic data and clinical outcomes of these patients were obtained by retrospective chart review.

Results:
A total of eight patients were enrolled in this study. All patients received ablative surgery at the National Cheng Kung University Hospital during May 2019 to May 2021, with their surgical defects reconstructed with unilateral inferiorly based nasolabial flap successfully. Among the five patients with lower lip cancer, one had a limited area of necrosis at flap tip. Another patient had a small orocutaneous fistula that healed spontaneously. No trismus or oral incompetence was noted following recovery. For the three patients with commissural cancer, a second stage commisuroplasy was needed after primary reconstruction. One patient had limited wound dehiscence at mouth angle following surgery, resulting in mild oral incompetence. Although mild trismus was noted in these three commissural cancer patients, all patients resumed normal diet during follow-up.

Conclusion:
Inferiorly based nasolabial flap is an excellent local flap for lower lip reconstruction following cancer ablative surgery. It is also a viable option for reconstruction of oral commissural defects. Minimal donor side morbidity, good functional recovery, and esthetic outcomes can be achieved with meticulous flap design.
Development of eosinophilic granulomatosis with polyangiitis during the clinical course of microscopic polyangiitis: A case report
Authors: Ide Hiroyuki , Shimizu Toshimasa , Koike Yuta , Abe Kuniko , Shigematsu Kazuto , Nishihata Shinya , Kojima Kanako , Ichinose Kunihiro , Kawakami Atsushi 
Published: November 2022

Rationale:
Eosinophilic granulomatosis with polyangiitis (EGPA) is belongs to the antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) subgroups. EGPA, unlike other subgroups of AAV, including microscopic polyangiitis (MPA) and granulomatosis with polyangiitis, has the unique feature that both ANCA and eosinophilic inflammation are involved in its pathogenesis. Although AAV often relapses, there are currently no reports of EGPA developing during other subgroups of AAV. Herein, we document a case of EGPA that developed during the clinical course of MPA.

Patient concerns:
A 61-year-old Japanese woman was diagnosed with MPA based on interstitial lung disease and myeloperoxidase-ANCA positivity. After starting immunosuppression therapy, including prednisolone and tacrolimus, she was expected to achieve clinical remission. Nonetheless, she occasionally experienced MPA relapse, which required an increased prednisolone dose, rituximab, intravenous cyclophosphamide, and plasma exchange. Three years after MPA onset, she developed renal amyloidosis; thus, subcutaneous tocilizumab was added to her regimen. Following clinical remission, the administration interval of her subcutaneous tocilizumab therapy was extended and immunosuppressants were discontinued. She then developed bronchial asthma and mild eosinophilia (eosinophilic count: ~1000/μL). Further, a year later, she underwent total hip replacement using a titanium implant. Subsequently, she developed abnormal sensation in both hands, numbness, and muscle weakness, as well as palpable purpura and massive eosinophilia (eosinophilic count: ~8500/μL).

Diagnosis:
We diagnosed the patient with EGPA based on 5 items (asthma, multiple mononeuropathies, sinus abnormality, and extravascular eosinophils) of the 1990 American College of Rheumatology classification criteria.

Interventions:
We administered 400 mg/kg intravenous immunoglobulin for 5 consecutive days, 300 mg mepolizumab subcutaneously every 4 weeks, and 40 mg/day prednisolone following pulsed methylprednisolone therapy (1000 mg/day for 3 consecutive days).

Outcomes:
After these treatments, the patient’s symptoms improved, and eosinophilic count and inflammatory markers declined.

Lessons:
The present case suggests that EGPA can be induced by the development of eosinophilic inflammation in other subgroups of AAV.
Effect of glomerular filtration rate in patients undergoing percutaneous coronary intervention: A systematic review and meta-analysis
Authors: Zhu Xiang , Zhang Pin , Xiong Jinrui , Wang Nan , Yang Shanlan , Zhu Ruoling , Zhang Langlang , Liu Weixin , Wu Lei 
Published: November 2022

Background:
Through meta-analysis of the relationship between glomerular filtration rate and major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI), we studied the impact of glomerular filtration rate on the prognosis of PCI.

Methods:
We collected literature on the incidence of MACE in patients with chronic kidney disease (CKD; estimated glomerular filtration rate < 60 mL/minute/1.73 m2) and patients with nonchronic kidney disease undergoing PCI. The search period was from January 1, 2000, to November 1, 2021. The searched databases included CNKI, Chinese Wanfang Data, China Biology Medicine disc, Web of Science, PubMed, and Cochrane Library. We used subgroup analysis and meta-regression to assess heterogeneity.

Results:
Twenty-one eligible studies were included, with 46,255 samples included, 4903 cases of MACE (10.6%), and patients with CKD had a higher risk of MACE after PCI (Risk ratios = 1.67; 95% confidence interval: 1.51–1.85). Multivariate meta regression results show that heterogeneity is related to region. The risk of MACEs in patients with CKD is different in different regions, and North America has the lowest risk, with an risk ratios value of 1.21 (95% confidence interval: 1.08–1.35).

Conclusion:
Chronic kidney disease will increase the probability of MACE in patients with myocardial infarction after PCI and affect the prognosis of PCI. Therefore, clinical attention should be given to assessing glomerular filtration rate effects while treating patients with myocardial infarction with the PCI procedure.
Effect of task-oriented training on gross motor function, balance and activities of daily living in children with cerebral palsy: A systematic review and meta-analysis
Authors: Zai Weiyi , Xu Ning , Wu Wei , Wang Yueying , Wang Runfang 
Published: November 2022

Background:
To systematically evaluate task-oriented training (TOT) on the improvement of gross motor function, balance and activities of daily living in children with cerebral palsy (CP).

Methods:
A number of randomized controlled trials (RCTs) of TOT in children with CP were searched from Pubmed, Cochrane Library, Web of Science, EmBase, China National Knowledge Infrastructure, Chinese Biology Medicine, Chinese Scientific Journals Database and Wanfang data from the establishment of database to March 2022. The methodological quality of the included studies was evaluated, and meta-analysis was performed by RevMan5.4 software.

Results:
A total of 16 studies were included in the systematic review (n = 893). Meta-analysis showed that the gross motor function measure (GMFM) (MD = 11.05, 95%CI [8.26, 13.83], P < .00001), dimension D (MD = 3.05, 95%CI [1.58, 4.53], P < .0001) of the GMFM, dimension E (MD = 7.36, 95%CI [5.88, 8.84], P < .00001) of the GMFM, the Berg Balance Scale (BBS) (MD = 6.23, 95%CI [3.31, 9.15], P < .0001), the pediatric evaluation of disability inventory (PEDI) mobile function (MD = 6.44, 95%CI [3.85, 9.02], P < .00001) score improved significantly in the TOT group compared with the control group.

Conclusions:
Current evidence shows that TOT could effectively improve gross motor function, balance and activities of daily living in children with CP. Due to the limitations of the number and quality of the included studies, the above conclusions need to be verified by more high-quality studies.
Brief Report: T-Cell Receptor α Repertoire Diversity at Birth After in utero Exposure to HIV Integrase Strand-Transfer Inhibitors
Authors: de Villartay Jean Pierre , Pannier Emmanuelle , Sibiude Jeanne , Frange Pierre , Tubiana Roland , Blanche Stéphane 
Published: November 2022

Abstract:
Effectiveness of anti-HIV in the prevention of perinatal transmission has been established. Assessing the tolerance of drug exposure during pregnancy is of the utmost importance given the number of children exposed. HIV integrase and the recombinase-activating gene enzyme involved in the establishment of the T-lymphocyte repertoire show structural similarity. The inhibition of recombinase-activating (RAG) gene by anti-integrases is observed in vitro, in a variable way according to the molecules. Here, we show that in utero exposure to raltegravir did not alter the T-lymphocyte repertoire of 12 newborns. These reassuring data merit verification for other anti-integrases. (ClinicalTrial.org NCT 04024150).
Primary Neuroendocrine Carcinoma of Pineal Gland With Extensive Meningeal Metastasis Detected by 18F-NOTATATE PET/CT
Authors: Deng Yujiao , He Limeng , Gao Hanyan , Deng Ying , Zhang Wei 
Published: November 2022

AbstractPrimary neuroendocrine tumor of the pineal gland is a rare disease. A 44-year-old woman with right cerebellopontine angle metastatic small cell neuroendocrine carcinoma underwent18F-FDG and18F-NOTATATE PET/CT scans.18F-NOTATATE PET/CT showed intense uptake in the pineal gland lesions and multiple foci of intense focus of uptake in the intracranial leptomeningeal and whole spinal canal. However, the lesions are less impressive on18F-FDG PET/CT.
Brain PET Imaging of 11C-Methionine, 18F-FDG, and 18F-THK5351 in a Case of Lymphomatoid Granulomatosis
Authors: Higashihara Mana , Ishibashi Kenji , Tokumaru Aya M. , Ishii Kenji , Iwata Atsushi 
Published: November 2022

Abstract
A 52-year-old woman complained of upper respiratory symptoms and subsequently developed Wallenberg syndrome. Chest CT and brain MRI revealed multiple nodular lesions in the lungs and brain. She was pathologically diagnosed with low-grade lymphomatoid granulomatosis by lung biopsy. Brain PET examinations using 11C-methionine, 18F-FDG, and 18F-THK5351 were performed. Uptake of 11C-methionine and 18F-FDG was slightly increased in some lesions, likely reflecting the degree of inflammatory cell infiltration. 18F-THK5351 uptake was significantly increased in all lesions, likely reflecting the degree of reactive astrogliosis. This case illustrates the utility of PET studies for diagnosing lymphomatoid granulomatosis and provides insight into its pathophysiology.
Diverse Patterns and Clinical Significance of 11C-Methionine PET in Dysembryoplastic Neuroepithelial Tumors
Authors: Kim Joo Whan , Kang Yeon-koo , Paeng Jin Chul , Kim Seung-Ki , Lim Byung Chan , Kim Ki Joong , Phi Ji Hoon 
Published: November 2022

Purpose
Dysembryoplastic neuroepithelial tumors (DNETs) are slow-growing epilepsy-associated tumors. Low or normal 11C-methionine (MET) PET uptake helps to differentiate DNETs from other low-grade gliomas. However, diverse MET-PET uptake in DNETs has been observed. The aim of this study is to measure the clinical significance and prognostic value of MET-PET in DNET management.

Patients and Methods
Retrospective review of 26 DNET patients was done. Clinical characteristics, radiologic findings, and visual and quantitative MET-PET results were analyzed. PET uptake was calculated as the tumor–to–homotopic mirror ratio (TNRm) and tumor–to–contralateral cortex ratio (TNRc). The clinical activity of the tumors at the time of PET was classified into active and quiescent groups. The surgical outcome was defined as a composite of 2 different aspects: tumor progression and/or clinical events such as seizure recurrence or tumor bleeding.

Results
Twenty-seven MET-PET examinations (20 initial MET-PET and 7 MET-PET during follow-up) were included. Clinically active tumors at the time of PET presented significantly higher values of TNRm and TNRc than quiescent tumors. High MET-PET uptake by visual grading, TNRm ≥ 1.90, and TNRc ≥ 1.85 exhibited poor prognosis for event-free survival.

Conclusions
MET-PET uptake correlates well with the clinical behavior of DNETs at the time of PET examination. Moreover, High MET-PET uptake is closely related to seizure recurrence if tumors are not entirely resected. Efforts to achieve gross total resection should be made for DNETs with high MET-PET uptake.
Comparisons of Respiratory Syncytial Virus (RSV) and Influenza: Population Characteristics and Clinical Outcomes in Hospitalized Adults
Authors: Begley Katherine M. , Monto Arnold S. , Lamerato Lois E. , Malani Anurag N. , Lauring Adam S. , Talbot H. Keipp , Gaglani Manjusha , McNeal Tresa , Silveira Fernanda P. , Zimmerman Richard K. , Middleton Donald B. , Ghamande Shekhar , Murthy Kempapura , Kim Lindsay , Ferdinands Jill M. , Patel Manish M. , Martin Emily T. 
Published: November 2022

AbstractBackgroundRespiratory syncytial virus (RSV) is under-recognized in hospitalized adults. We evaluated severity of acute respiratory illness (ARI) including intensive care unit (ICU) admission and mechanical ventilation in a national surveillance network.MethodsHospitalized adults who met a standardized ARI case definition were prospectively enrolled across three respiratory seasons from hospitals participating across all sites of the U.S. Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN, 2016-2019). Multivariable logistic regression was used to test associations between lab-confirmed infection and characteristics and clinical outcomes.ResultsAmong 10,311 hospitalized adults, 6% tested positive for RSV (n=622), 18.8% positive for influenza (n=1,940), and 75.1% negative for RSV and influenza (n=7,749). The proportion of adults with Congestive Heart Failure (CHF) or Chronic Obstructive Pulmonary Disease (COPD) was higher among adults with RSV than influenza (CHF: 37.3% vs. 28.8%, p<0.0001; COPD: 47.6% vs. 35.8%, p<0.0001). Patients with RSV had higher odds of experiencing length of stay ≥8 days [OR=1.38 (95% CI: 1.06-1.80), p-value=0.02] and invasive or noninvasive mechanical ventilation [OR=1.45 (95% CI: 1.09-1.93), p-value=0.01] compared with influenza patients.ConclusionsOur findings suggest patients with RSV might incur worse outcomes than influenza in hospitalized adults, who are likely to have pre-existing cardiopulmonary conditions.
Age variability and time averaging in oyster reef death assemblages
Authors: Durham Stephen R. , Dietl Gregory P. , Hua Quan , Handley John C. , Kaufman Darrell , Clark Cheryl P. 
Published: November 2022

ABSTRACTA lack of temporal context for paleoecological data from molluscan death assemblages (DAs) makes integrating them with monitoring data from living communities to inform habitat management difficult. Here we illustrate this challenge by documenting the spatial and stratigraphic variability in age and time-averaging of oyster reef death assemblages. We radiocarbon dated a total of 573 oyster shells from samples of two burial depths on 28 oyster reefs around Florida and found 1) that spatial and stratigraphic variability in DA sample ages and time-averaging are of similar magnitude, and 2) that the shallow oyster reef DAs are among the youngest and highest-resolution molluscan DAs documented to-date, with most having time-averaging estimates of decades or less. This information increases the potential usefulness of the DAs for habitat management because measured indicators can be placed in temporal context relative to monitoring data. More broadly, the results highlight the potential to obtain decadal-scale resolution from oyster bioherms in the fossil record.
Complexes Formed by Mixing Tumor-derived Extracellular Vesicles with Polymeric Surfactants for Personalized Therapeutic Vaccine
Authors: Zeng Wenfeng , Tian Hongjian , Wang Zihao , Li Siqi , Jin Lingtao , Liang Wei 
Published: November 2022

AbstractThe personalized therapeutic vaccine is an ideal weapon to eliminate tumors. However, the core steps of manufacturing personalized cancer vaccines are identifying tumor-specific antigens (TSAs, also called neoantigens) and HLA epitope prediction, which is time-consuming and labor-intense. Tumor-derived extracellular vesicles (TEVs) are alternative sources of neoantigens. However, the immunosuppressive nature of TEVs limits their application in such immunotherapy. In this study, we present a new strategy to maintain neoantigens in TEVs and diminish the immunosuppression by deconstructing the structure of TEVs with polymeric surfactant polyethylene glycol-phosphatidylethanolamine (PEG-PE). Together with adjuvant MPLA, the newly formed micelle-like complexes compose a therapeutic vaccine (MLC-V). Results show that MLC-V is capable of eliciting neoantigen-specific T-cell responses, restoring TEV-induced immunosuppression, and preventing lung metastasis of murine melanoma. MLC-V also exhibits outstanding anti-tumor efficacy in multiple tumor models. MLC-V can be used as a personalized therapeutic vaccine in a mimetic pre-clinical MC38 model and the anti-tumor effect of MLC-V was synergistically enhanced by PD-1 mAb. Taken together, the present study demonstrates a time-saving, low-cost, and simplified strategy to produce personalized therapeutic vaccines based on MLC-V platform technology.