bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mining of chicken muscle growth genes and the function of important candidate gene RPL3L in muscle development
Authors: Lin Shudai , Xian Mingjian , Ren Tuanhui , Mo Guodong , Zhang Li , Zhang Xiquan 
Published: November 2022

The birth weight of chickens does not significantly affect the weight at slaughter, while the different growth rate after birth was one of the important reasons for the difference in slaughter weight. Also, the increase in chickens’ postnatal skeletal muscle weight is the main cause of the slaughter weight gain, but which genes are involved in this biological process is still unclear. In this study, by integrating four transcriptome datasets containing chicken muscles at different developmental times or different chicken tissues in public databases, a total of nine candidate genes that may be related to postnatal muscle development in chickens were obtained, including RPL3L, FBP2, ASB4, ASB15, CKMT2, PGAM1, YIPF7, PFKM, and LDHA. One of these candidate genes is RPL3L, whose 42 bp insertion/deletion (indel) mutation significantly correlated with multiple carcass traits in the F2 resource population from Xinghua chickens crossing with White Recessive Rock (WRR) chickens, including live weight, carcass weight, half eviscerated weight, eviscerated weight, breast meat weight, wing weight, leg muscle shear force, and breast muscle shear force. Also, there was a very significant difference between different genotypes of the RPL3L 42 bp indel mutation in these trains. Further experiments showed that RPL3L was highly expressed in chicken skeletal muscle, and its overexpression could promote the proliferation and inhibit the differentiation of chicken myoblasts by regulating ASB4 and ASB15 expression. Our findings demonstrated that the RPL3L 42 bp indel may be one of the molecular markers of chicken weight-related traits.
Effects of physical activity and sleep duration on fertility: A systematic review and meta-analysis based on prospective cohort studies
Authors: Zhao Fanqi , Hong Xiang , Wang Wei , Wu Jingying , Wang Bei 
Published: November 2022

ObjectiveSubfertility is a common problem for couples in modern society. Many studies have confirmed that lifestyle factors can affect fertility although there are conflicting conclusions relating to the effects of physical activity and sleep duration on fertility. In this study, we aimed to summarize and analyze the available evidence.MethodsPubMed, Web of Science, Cochrane, and Embase databases (as of October 14, 2022) were systematically searched for eligible prospective cohort studies. Data were extracted and effect values were combined. We also performed methodological quality and bias risk assessments for all the included studies.ResultsA total of 10 eligible articles were included in our analysis; seven investigated the relationship between physical activity and fertility, and three investigated the effect of sleep duration on fertility. Compared with the lowest level of physical activity, high intensity physical activity (the highest levels of physical activity) was negatively correlated with fertility [odds ratio (OR) = 0.84; 95% confidence interval (CI): 0.70, 1.00, I2 = 64%]. However, we did not find an association between moderate intensity physical activity and fertility (OR = 1.09; 95% CI: 0.98, 1.22, I2 = 60%). We observed an inverse association between limited sleep duration (≤ 7 h) and fertility (OR = 0.92; 95% CI: 0.84, 1.00, I2 = 0%) compared with 8 h of sleep. The relationship between long sleep duration (≥9 h) and fertility was not statistically significant (OR = 0.85; 95% CI: 0.60, 1.21, I2 = 83%). According to the Newcastle-Ottawa Scale score, the overall quality of the research articles included was ranked as medium to high (6–9). Through GRADE system, the quality of evidence for the impact of high intensity physical activity and limited sleep duration on fertility was moderate, while the quality of evidence for the impact of moderate intensity physical activity and long sleep duration on fertility was low.ConclusionThe current evidence shows that high intensity physical activity and limited sleep time are negatively related to fertility. But there was great heterogeneity among studies, and the quality of research evidence was low to median. Thus, further high-quality research is needed to confirm this conclusion.PROSPERO registration numberCRD42022298137.
Effects of 5-alpha reductase inhibitors prior to Holmium Laser Enucleation of the prostate: Does increased adenoma density result in prolonged morcellation times?
Authors: Ganesh Meera B. , Lee Matthew S. , Han Joshua G. , Assmus Mark A. , Dean Nicholas , Helon Jessica W. , Krambeck Amy E. 
Published: November 2022

IntroductionThe use of 5-alpha reductase inhibitors (5-ARIs) has been shown to improve lower urinary tract symptoms (LUTS) and decrease prostate size in men with benign prostate hyperplasia (BPH). 5-ARI therapy could increase prostate tissue density through increased collagen deposition and contraction of stromal/epithelial components. Increased tissue density could prolong morcellation times, but the effects of preoperative 5-ARI exposure on morcellation efficiency during Holmium Laser Enucleation of the Prostate (HoLEP) are not well described. Herein, we examine outcomes after HoLEP of patients on pre-operative 5-ARIs.MethodsA retrospective review of patients undergoing HoLEP by an expert surgeon from Jan – Oct 2021 was performed. Student t-tests and chi-square tests were performed for continuous and categorical variables, respectively. Matched-pair analysis was performed using SPSS v28 (IBM, 2022). A p-value &lt;0.05 was determined statistically significant. All other statistical analyses were performed using SAS v9.4 (SAS, 2019).ResultsA total of 322 patients underwent HoLEP during the study period and 84 patients had pre-operative 5-ARI exposure. Patients in the 5-ARI group had larger preoperative prostate size (p = 0.016). Morcellation time was longer (p=0.01), specimen weight was higher (p=0.02), and morcellation efficiency (p=0.02) was lower in the 5-ARI group. After matching, there were 67 patients in each chort (total 134) and these associations for size, morcellation time, specimen weight, and morcellation efficiency were no longer seen (p=0.8, 0.6, 0.5, and 0.7, respectively). Furthermore, no associations between 5-ARI and post-operative admissions or ED visits were noted.ConclusionIn this retrospective study, preoperative use of 5-ARIs did not affect enucleation or morcellation efficiency. Thus, preoperative 5-ARI therapy does not appear to alter outcomes after HoLEP.
Transmission Characteristics and Predictive Model for Recent Epidemic Waves of COVID-19 Associated With OMICRON Variant in Major Cities in China
Authors: Zheng Yangcheng , Wang Yunpeng 
Published: November 2022

Objectives: Waves of epidemics associated with Omicron variant of Coronavirus Disease 2019 (COVID-19) in major cities in China this year have been controlled. It is of great importance to study the transmission characteristics of these cases to support further interventions.Methods: We simulate the transmission trajectory and analyze the intervention influences of waves associated with Omicron variant in major cities in China using the Suspected-Exposed-Infectious-Removed (SEIR) model. In addition, we propose a model using a function between the maximum daily infections and the duration of the epidemic, calibrated with data from Chinese cities.Results: An infection period of 5 days and basic reproduction number R0 between 2 and 8.72 are most appropriate for most cases in China. Control measures show a significant impact on reducing R0, and the earlier control measures are implemented, the shorter the epidemic will last. Our proposed model performs well in predicting the duration of the epidemic with an average error of 2.49 days.Conclusion: Our results show great potential in epidemic model simulation and predicting the end date of the Omicron epidemic effectively and efficiently.
Synergism between Extracts of Garcinia mangostana Pericarp and Curcuma in Ameliorating Altered Brain Neurotransmitters, Systemic Inflammation, and Leptin Levels in High-Fat Diet-Induced Obesity in Male Wistar Albino Rats
Authors: Labban Ranyah Shaker M. , Alfawaz Hanan A. , Amina Musarat , Bhat Ramesa Shafi , Hassan Wail M. , El-Ansary Afaf 
Published: November 2022

This study aims to explore the effects of Garcinia mangostana (mangosteen) and Curcuma longa independently and synergistically in modulating induced inflammation and impaired brain neurotransmitters commonly observed in high-fat diet-induced obesity in rodent models. Male albino Wistar rats were divided into four experimental groups. Group I, control, obese, fed on a high-fat diet (HFD), and Group II-IV, fed on HFD then given mangosteen extract (400 mg/kg/day) and/or Curcuma (80 mg/kg/day), or a mixture of both for 6 weeks. Plasma pro-inflammatory cytokines, leptin, and brain serotonin, dopamine, and glutamate were measured in the five studied groups. G. mangostana and Curcuma longa extracts demonstrate antioxidant and DPPH radical scavenging activities. Both induced a significant reduction in the weight gained, concomitant with a non-significant decrease in the BMI (from 0.86 to 0.81 g/cm2). Curcuma either alone or in combination with MPE was more effective. Both extracts demonstrated anti-inflammatory effects and induced a significant reduction in levels of both IL-6 and IL-12. The lowest leptin level was achieved in the synergistically treated group, compared to independent treatments. Brain dopamine was the most affected variable, with significantly lower levels recorded in the Curcuma and synergistically treated groups than in the control group. Glutamate and serotonin levels were not affected significantly. The present study demonstrated that mangosteen pericarp extract (MPE) and Curcuma were independently and in combination effective in treating obesity-induced inflammation and demonstrating neuroprotective properties.
Itens digitais para avaliação da oralidade em Língua Portuguesa
Authors: Saito Fabiano Santos 
Published: November 2022

O objetivo desta pesquisa aplicada é apresentar considerações teóricas e práticas sobre a produção de itens digitais voltados para a avaliação da oralidade em Língua Portuguesa. Esta pesquisa faz parte do projeto “Do papel para a tela: proposição de novas formas de avaliar a proficiência em Língua Portuguesa com itens produzidos para plataformas digitais”, financiado pela Fundação Centro de Políticas Públicas e Avaliação da Educação/Universidade Federal de Juiz de Fora (doravante Fundação CAEd/UFJF) e desenvolvido ao longo do ano de 2020. Como suporte teórico, parte-se dos pressupostos da oralidade em Língua Portuguesa, bem como os princípios de design de itens de avaliação e de itens digitais, bem como a Teoria de Resposta ao Item (TRI). Metodologicamente esta é uma pesquisa aplicada, de abordagem exploratória e qualitativa. Para a produção experimental dos protótipos de itens digitais foi utilizada a plataforma TAO (Testing Assisté par Ordinateur). A partir da produção dos protótipos de itens digitais, realizou-se uma análise qualitativa sobre o design de itens digitais e sua possibilidade de aplicação em avaliações de larga escala. Como resultados parciais, aponta-se que a produção de itens digitais permite a exploração de suportes multimídia e hipermídia, que permitem a avaliação de habilidades de compreensão da escuta, que não são consideradas em instrumentos de avaliação impressos.
Fixer le plan ou gérer le profil : l’exemple du Sillon du Talberv
Authors: Pinot Jean-Pierre 
Published: November 2022

Depuis près de trente ans, la crainte que le Sillon du Talberv, en Pleubian, Côtes d'Armor, ne se rompe et cesse ainsi de protéger contre les houles de Nord-Ouest les littoraux de Pleubian, de Bréhat et de la presqu'île paimpolaise a conduit à entreprendre des travaux lourds de fixation que l'auteur a suivis de bout en bout.
Le Sillon du Talberv était une flèche de sable (près de la racine) et de galets (vers la pointe) de 3 km de long, faisant face aux houles atlantiques. Il reculait d'une cinquantaine de mètres par siècle, avec de temps à autre des ruptures, parfois définitives (début du XVIIIème siècle), plus souvent temporaires (second quart du XIXème siècle), et des variations dans la cadence du recul. L'orientation générale variait de quelques degrés, selon les oscillations de la circulation atmosphérique entre ses phases méridiennes et ses phases zonales.
A partir de 1962, la flèche a connu des ruptures ou des submersions qui ont inquiété les riverains des côtes qu'elle protège. Aussi un Syndicat Mixte de Protection s'est-il constitué pour protéger le Sillon. Des sommes importantes ont ainsi été dépensées pour tenter de figer le plan de cette flèche, dont seul le dernier kilomètre évolue aujourd'hui de façon naturelle. Le reste est devenu une sorte de digue inavouée, dont la racine autrefois sableuse est stabilisée par un épi et des enrochements, mais dont les parties centrales, sur lesquelles on a essayé de nombreux types d'enrochements ou d'autres modes d'intervention, ont reculé d'une soixantaine de mètres au cours des vingt dernières années, tandis que, les matériaux s'étalant vers le revers, les submersions sont de plus en plus fréquentes.
Aussi, depuis trois ans, a-t-on renoncé à poursuivre les travaux de fixation du plan de la flèche, en se bornant à des interventions ponctuelles pour corriger les dégradations du profil après chaque tempête. Mais aucun plan de gestion cohérente n'a encore été adopté, et en particulier on laisse toujours des véhicules circuler sur la dune. Il est urgent d'adopter un plan raisonné de gestion, et d'entretien immédiat, qui serait beaucoup moins coûteux que des interventions lourdes et tardives. Mais la structure actuelle des décisions et des financements incite à préférer les gros travaux, tandis que la gestion par la commune de cette partie du Domaine Public Maritime ne se prête guère à l'adoption de mesures impopulaires.
La communication interculturelle : constitution d'une nouvelle discipline
Authors: Mauviel Maurice 
Published: November 2022

Intercultural communication : the creation of a new discipline.
Intercultural communication, a university discipline which appeared in the United-States at the end of the 60s, is the scientific study of the barriers to communication between individuals of different cultures and sub-cultures.
This field of research opened when the two trends relating to culture and communication overlapped from 1965 onwards. Intercultural communication, in order to build up its object and to assert its legitimacy, relies on a certain number of subdisciplines derived from contemporary, cultural anthropology : cognitive anthropology and symbolics in particular. It also gives great importance to the phenomenological alternative which inspires the social theory of today (ethnome-thodology applied to the school sector, for instance).
Intercultural communication is particularly interesting for the world of education, international management and all the institutions concerned with the improvement of interethnic relations.
The intermixing of populations in the world of today will more and more impose the development of serious scientific studies in this field.
Detection Rate of Immunoglobulins G to Toxocar Antigens in the Republic of Belarus
Authors: Красавцев Е.Л. , Подоляко М.В. 
Published: November 2022

Цель. Изучить частоту выявления иммуноглобулинов G к антигенам токсокар у детей в различных регионах Республики Беларусь, различного возраста, пола.Материалы и методы. Анализ на иммуноглобулины G к антигенам токсокар был взят у 11 541 ребенка. Сравнение частоты выявления иммуноглобулинов G к антигенам токсокар у детей, проживающих в различных регионах Республики Беларусь, различного пола, возраста было произведено методами непараметрической статистики (таблицы 2×2, критерий χ2).Результаты. В результате исследования 11 541 ребенка иммуноглобулины G к антигенам токсокар были выявлены у 1153 человек (10,0%). Наиболее часто иммуноглобулины G к антигенам токсокар регистрировались в возрастной группе от 12 до 15 лет (15,1%), реже – в возрасте до 3 лет (6,9%, р<0,001, χ2=6,7). Самый большой процент положительных результатов зарегистрирован у детей в Могилевской области (15,2%), а самый низкий – у детей в г. Минске (7,9%) и Гомельской области (10,1%). Наиболее часто иммуноглобулины G к антигенам токсокар выявлялись у детей городов Орши (18,75%) и Бобруйска (17,6%), реже – у жителей Борисова (5,3%, р<0,001) и Новополоцка (6,7%, р<0,001).Выводы. В Республике Беларусь частота обнаружения у детей иммуноглобулинов G к антигенам токсокар имеет возрастные и региональные особенности. Наиболее часто иммуноглобулины G к антигенам токсокар отмечались в возрастной группе от 12 до 15 лет (15,1%), реже – в возрасте до 3 лет (6,9%, р<0,001, χ2=6,7).
Purpose. To study the detection rate of immunoglobulins G to toxocar antigens in children of different age and gender from different regions of the Republic of Belarus.Materials and methods. Immunoglobulin G tests for toxocar antigens were performed in 11,541 children. The detection rate of immunoglobulin G to toxocar antigens in children of different gender and age living in different regions of the Republic of Belarus was compared using nonparametric statistics (Tables 2×2, χ2 criterion).Results. A survey of 11,541 children revealed G immunoglobulins to toxocar antigens in 1,153 individuals (10.0%). Immunoglobulins G to toxocar antigens were most frequently registered in the age group of 12 to 15 years (15.1%), and less frequently in the age group under 3 years (6.9%, p<0.001, χ2=6.7). The highest percentage of positive results was registered among children living in the Mogilev region (15.2%), and the lowest one among children living in the city of Minsk (7.9%) and in the Gomel region (10.1%). Immunoglobulins G to toxocar antigens were most frequently revealed in children of Orsha (18.75%) and Bobruisk (17.6%), and less often in residents of Borisov (5.3%, p<0.001) and Novopolotsk (6.7%, p<0.001).Conclusions. In the Republic of Belarus, the detection rate of immunoglobulin G to toxocar antigens in children varies by age and region. Immunoglobulin G to toxocar antigens was revealed most frequently in the age group of 12–15 years (15.1%), and less frequently in the age group under 3 years (6.9%, p<0.001, χ2=6.7).
Ischemic Stroke and COVID-19: A Literature Review
Authors: Наумова Г.И. , Прусакова О.И. , Наумов А.Д. 
Published: November 2022

Целью работы являлся обзор литературы об экспериментальных и клинических исследованиях, отражающих патогенетическую роль возможного использования сукцинатов в коррекции гипоксии при ишемическом инсульте и COVID-19. Было проанализировано 57 зарубежных и отечественных литературных источников, касающихся роли Цитофлавина в лечении гипоксии при ишемическом инсульте и COVID-19. Анализ литературы показал, что в основе патогенеза COVID-19 и ишемических поражений головного мозга лежит гипоксия тканей, запускающая весь каскад патоморфологических событий, приводящих к развитию полиорганной недостаточности. В экспериментальных и клинических исследованиях отражен положительный эффект коррекции гипоксии тканей с использованием такого сукцината, как Цитофлавин. Назначение Цитофлавина приводит к лучшей и опережающей группу сравнения динамике неврологического, функционального и когнитивного статуса. Таким образом, по результатам проведенного анализа отечественной и зарубежной литературы выявлены высокая частота и полиморфность симптомов поражения ЦНС, а также важная роль сосудистого поражения головного мозга и нейродегенерации в патогенезе COVID-19.
The purpose of the work was to review the literature on experimental and clinical studies reflecting the pathogenetic role of the possible use of succinate in correction of hypoxia in ischemic stroke and COVID-19. 57 foreign and domestic literature sources regarding the role of Cytoflavin in hypoxia management in ischemic stroke and COVID-19 were analyzed. The analysis of the literature showed that the underlying the pathogenesis of COVID-19 and ischemic brain lesions is tissue hypoxia, triggering the whole cascade of pathomorphological events leading to the development of multiple organ failure. Both experimental and clinical studies reflect the positive effect of tissue hypoxia correction with the use of such succinate as Cytoflavin. The administration of Cytoflavin results in better and outpacing the comparison group dynamics of neurological, functional and cognitive status. Thus, the results of the analysis of domestic and foreign literature revealed a high incidence and polymorphism of CNS lesion symptoms, as well as an important role of cerebral vascular lesions and neurodegeneration in COVID-19 pathogenesis.
Reducing Gas Emissions from Transport by Introducing Hybrid Electric Vehicles
Authors: LUPCHIAN Mariana 
Published: November 2022

The work presents one of the most serious problems related to air pollution as it can have effects both in the short term, but especially in the medium and long term. By increasing the number of automobiles put into circulation every year, in addition to the increase in fuel consumption, the problem of pollution has been accentuated, due to the noxious emissions of the internal combustion engines used for their propulsion. The requirement to reduce fuel consumption has become even more acute as it is closely related to environmental pollution.
Penggunaan Teknologi Geospasial dalam Upaya Konservasi Mangrove di Desa Margasari, Kabupaten Lampung Timur
Authors: Ryan Farhan , Mahakarya Sembahen Bintang , Abi Fajar Muhammad , Attorik Falensky Muhammad , Supriatna  
Published: November 2022

Program Sustainable Development Goals (SDGs) harus segera diwujudkan untuk kualitas kehidupan masyarakat dunia yang lebih baik. Poin ke-13 SDGs berusaha menjawab ancaman perubahan iklim dan pemanasan global, dan blue carbon merupakan bagian dari jawaban tersebut yang dapat diandalkan untuk menyerap karbon dioksida dan mengurangi jumlah gas rumah kaca. Indonesia merupakan negara terbesar dengan pulau terbanyak, 13.466 pulau, dan negara dengan garis pantai terpanjang yang terbentang lebih dari 95.180 km dimana menampung beberapa ekosistem laut tropis terkaya di dunia, dimana Lampung merupakan provinsi yang mempunyai hutan mangrove terkecil ketiga di Pulau Sumatera. Sayangnya 50% kerusakan mangrove di Lampung terjadi di pesisir timurnya, dan Desa margasari salah satu kawasan pesisir terdampak degradasi yang kian terjadi. Penelitian ini bertujuan untuk (1) menganalisis perubahan luas kawasan mangrove di Desa Margasari Kabupaten Lampung Timur selama periode 2014 – 2020 yang diketahui melalui citra satelit Landsat dan (2) mengidentifikasi faktor yang menyebabkan perubahan kawasan mangrove di Desa Margasari Kabupaten Lampung Timur. Untuk memperoleh perubahan luas kawasan mangrove digunakan NDVI dengan menganalisis persentase penurunan serta luasannya di tahun yang beda. Selain itu, Klasifikasi Unsupervised juga dilakukan untuk mengidentifikasi faktor penyebab perubahan tersebut. Pada kesimpulannya luasan kawasan Mangrove menurun pada tahun 2014-2017 sebesar -10,75%; dan 2017-2020 sebesar -42,98% diikuti dengan meningkatnya tambak, merambahnya pemukiman, serta faktor alami, sehingga hal-hal tersebut dapat disimpulkan sebagai ancaman terbesar bagi pelestarian mangrove.