bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aspirin inhibits proliferation of gastric cancer cells via IL 6/STAT3 signaling pathway
Authors: Tang Shunyu , Liu Yun , Liu Changqing , Zhao Jiayun 
Published: September 2022

Purpose: To study the effect of aspirin on the proliferation and apoptosis of gastric cancer cells, and its key molecular mechanism of action.
Methods: Gastric cancer SGC7901 cells were treated with aspirin at concentrations of 0, 1, 2 and 4 mmol/L. Cell proliferation was measured using cell counting kit (CCK)-8 assay, while messenger ribonucleic acid (mRNA) expressions of interleukin (IL)-6, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X protein (Bax) were assessed by reverse transcription-polymerase chain reaction (RT-PCR). Cell apoptosis was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL). Furthermore, the protein expression levels of the signal transducer and activator of transcription 3 (STAT3), phosphorylated STAT3 (p-STAT3), Bcl-2 and Bax were evaluated by Western blotting.
Results: Compared with control group, 1, 2 and 4 mmol/L aspirin groups showed lower cell proliferation, and decreased mRNA expressions of Bcl-2 and Bax and IL-6 release at 24, 48 and 72 h (p < 0.05). Cell apoptosis in the aspirin groups was higher than in the control group. Also, compared with the control group, 1 mmol/L aspirin group did not exhibit significant changes in the expressions of STAT3 and p-STAT3 at 72 h. On the other hand, the 2 mmol/L aspirin group at 72 h and the 4 mmol/L aspirin group exhibited significant increases in the expressions of STAT3 and p-STAT3 (p < 0.05). Furthermore, the levels of Bcl-2 and Bax declined in the aspirin groups when compared with the control group (p < 0.05).
Conclusion: Aspirin inhibits the proliferation of gastric cancer SGC7901 cells, and induces their apoptosis in vitro in IL-6/STAT3 signaling pathway. The results of the current study may provide new insight into the treatment of gastric cancer.
Effect of a combination of general anesthesia and superficial cervical plexus block with ropivacaine on patients undergoing thyroidectomy
Authors: Chen Xiao , Qin Yan , Zhao Xing , Liu Zhihu , Qu Zhenhua 
Published: September 2022

Purpose: To investigate the effect of a combination of general anesthesia and superficial cervical plexus block (SCPB) with ropivacaine on patients undergoing thyroidectomy.
Methods: Ninety-six (96) patients undergoing thyroidectomy were randomly divided into control and study group. Both groups were subjected to SCPB in combination with general anesthesia. Ropivacaine was used for SCPB in the study group. Vital signs, visual analogue scale (VAS) scores, and serum interleukin 1β (IL-1β) levels were determined at various time points (T) after tracheal intubation. Occurrence of adverse reactions was recorded.
Results: Compared with the control group, mean arterial pressure (MAP), heart rate (HR), diastolic blood pressure (DBP), and systolic blood pressure (SBP) levels from T1 to T5 were declined in study group (p < 0.01). VAS scores of study group were significantly lower at 12, 24, and 48 h after thyroidectomy than in control group (p < 0.05). At 5, 10 and 15 h after surgery, serum IL-1β level in study group was down-regulated (p < 0.05). Moreover, a marked decrease in the incidence of adverse reactions was also found in the study group post-surgery (p < 0.05).
Conclusion: Ropivacaine is effective for SCPB in combination with general anesthesia in patients undergoing thyroidectomy. It is safer and more feasible in SCPB when combined with general anesthesia. However, further clinical trials are required to validate this technique.
Effect of a combination of Tuina therapy and budesonide inhalation on asthma in children, and its influence on lung function and pro inflammatory f actors
Authors: Li Hanyi , Zhang Xinmei , Zhao Qijun , Bai Xiang , Wang Shuying 
Published: September 2022

Purpose: To determine the effect of a combination of Tuina therapy and budesonide inhalation on pediatric asthma, and its influence on lung function and levels of inflammatory factors.
Methods: Eligible 100 asthmatic children admitted to Provincial Maternity and Child-care Hospital, Lanzhou, Gansu Province, from January 2019 to January 2021 were randomized either to a control group or study group (1:1). The patients in control group were treated with budesonide inhalation, while the study group was given Tuina therapy in combination with budesonide inhalation. Treatment effectiveness, levels of inflammatory factors, immune functions and number of infections were evaluated in the patients.
Results: The study group exhibited higher effectiveness profile versus the control group (96 vs 82 %; p < 0.05). After treatment, decreases were observed in the frequency of asthmatic attacks and number of respiratory infections in the two groups, with lower results in the study group than in the control group (p < 0.05). There were marked decreases in the levels of IgG, TNF-α and IL-8 in both groups, with the study group showing higher reductions (p < 0.05).
Conclusion: Combined treatment with Tuina and budesonide inhalation decreases the levels of inflammatory factors, regulates immune function, and improves lung function of asthmatic children. Further investigation in a larger population would be required to establish the mechanism and clinical value of this therapy.
Resveratrol protects against sepsis induced acute kidney injury in mice by inducing Klotho mediated apoptosis inhibition
Authors: Chen Yu , Ye Xiaoting , Jin Shasha , Huang Weixia , Chen Chaosheng , Chen Xinxin 
Published: September 2022

Purpose: To investigate the mechanism of resveratrol protection against sepsis-induced acute kidney injury in mice.
Methods: A sepsis-induced acute kidney injury model was established in mice by cecal ligation and puncture (CLP). Sixty healthy male ICR mice were randomly divided into the sham operation (sham) group, sepsis-induced acute kidney injury model (CLP) group, CLP + low-dose (20 mg/kg) resveratrol treatment (CLP + ResL) group, CLP + high-dose (40 mg/kg) resveratrol treatment (CLP + ResH) group and CLP + Klotho (0.01 mg/kg) treatment (CLP + Klotho) group. All mice were administered treatment on the day after surgery and once every 24 h for 3 days. Various serum biochemical parameters and protein expressions were evaluated.
Results: After CLP, the levels of serum creatinine (Scr) and blood urea nitrogen (BUN) increased and the pathology was exacerbated. The protein and mRNA expression levels of Klotho and Bcl-2 decreased, while those of Bax and Caspase-3 increased (p < 0.05). After resveratrol and Klotho protein intervention, Scr and BUN levels recovered, and pathological changes were alleviated. The protein and mRNA expression levels of Klotho and Bcl-2 increased, while those of Bax and Caspase-3 decreased. The conditions of the mice in CLP + ResH group and the CLP + Klotho group improved more significantly than those of the mice in the CLP + ResL group (p < 0.05).
Conclusion: Resveratrol upregulates the expression of endogenous Klotho to exert its antiapoptotic effects, which can protect the kidneys of mice against sepsis-induced acute kidney injury. Thus, the compound has potentials for development for protection against acute kidney injury.
REALIZATION OF THE MAIN DIRECTIONS OF THE STATE CULTURAL POLICY IN NORTH OSSETIA AT THE END OF THE 20TH – THE BEGINNING OF THE 21ST CENTURIES
Authors: Тургиева З.А. , Туаева Б.В. 
Published: September 2022

В статье прослежены этапы и проанализированы основные направления деятельности государственных организаций в Республике Северная Осетия-Алания через призму историко-культурной составляющей в меняющемся российском государстве. Сегодня вопросы регулирования государственной культурной политики являются особенно актуальными. В сложившейся геополитической и социально-экономической обстановке важнейшими становятся ресурсы культурного развития страны, сохранения его единства через многообразие культур народов, населяющих Россию и ее регионы. На примере деятельности министерства культуры Северной Осетии рассматриваются особенности реализации государственных программ, национальных проектов, общественных инициатив, направленных на развитие культурной среды в постперестроечный период и на современном этапе. Важными составляющими этих процессов являются сохранение этнокультурной идентичности, материальных и нематериальных памятников культурного наследия, развитие человеческого потенциала, строительство культурной инфраструктуры и поддержка средств массовой информации. Изучение региональной культурной политики необходимо рассматривать в контексте истории общегосударственных трансформаций, с анализом деятельности профильных институтов развития и особенностей развития субъектов.
The article traces the stages and analyzes the main activities of state organizations in the Republic of North Ossetia-Alania through the prism of the historical and cultural component in the changing Russian state. Today, the issues of regulation of state cultural policy are especially relevant. In the current geopolitical and socio-economic situation, the resources of the country's cultural development, the preservation of its unity through the diversity of cultures of the peoples inhabiting Russia and its regions, become the most important. On the example of the activities of the Ministry of Culture of North Ossetia, the features of the fullfilment of state programs, national projects, public initiatives aimed at developing the cultural environment in the post-perestroika period and at the present stage are considered. Important components of these processes are the preservation of ethnocultural identity, tangible and intangible monuments of cultural heritage, the development of human potential, the construction of cultural infrastructure and support for the media. The study of regional cultural policy should be considered in the context of the history of nationwide transformations, with an analysis of the activities of specialized development institutions and the features of the development of subjects.
Gene Expression of Sperm Associated Antigen 8 and Ran-Binding Protein 9 on Azoospermic Male : Its Association with Spermatogenic Arrest
Authors: Deviana Tanifan Christina Agusta , Suryandari Dwi Anita , Yunaini Luluk 
Published: September 2022

Proteins that play an important role in the transcription process during spermatogenesis are CREMs that bind to their ACT activators that are suspected to be regulated by SPAG8 and RANBP9. Until now the role of both genes in the spermatogenic arrest process is not known. This study aims to determine the relative expression of Spag8 and RanBP9 on spermatogenic arrest and to analyze the correlation of expression of both genes.
This study is a cross sectional study using a sample of testicular biopsy with Johnsen 2 to 8 score. Relative expression analysis of Spag8 and RanBP9 using qRT-PCR technique with Livak calculation. The data obtained were analyzed statistically using ANOVA one way test for Spag8 and Kruskal Wallis test for RanBP9 with significance value p <0,05. The results of this study show that the relative expression of Spag8 and RanBP9 is highest on Johnsen 3 scores and is statistically significantly different (p <0.05). There is a positive correlation with a very strong correlation strength between SPAG8 and RANBP9 expressions. Based on the results of this study shows that both of these genes are candidates for spermatogenic arrest.
Prevalencia de hipertensión arterial sistémica persistente posterior a corrección percutánea de coartación de aorta en pacientes pediátricos en el “centro medico nacional 20 de noviembre issste”
Authors: Aguilar Jesus Francisco Montalvo , Astudillo Axel Abraham Serrano , Sandoval Antonio Salgado , Arizmendi Ramon Alejandro Flores , Aguilar Humberto Garcia 
Published: September 2022

La coartación de la aorta, es una cardiopatía congénita frecuente (aproximadamente 20 a 60 por cada 100,000 nacidos vivos) y se caracteriza por estenosis de la aorta descendente, habitualmente distal al origen de la subclavia izquierda, a la altura de la inserción del ligamento arterioso. Hay un predominio del sexo masculino y está asociada con otros defectos congénitos, como aorta bicúspide en el 50% de los casos. Los pacientes con coartación aórtica no corregida tienen una mala evolución clínica y una corta esperanza de vida, que en promedio es de 30 años, esencialmente por complicaciones asociadas a hipertensión arterial sistémica, persistiendo esta patología vascular en muchos debido a alteraciones en la regulación cardiovascular.
Incidencia de las competencias docentes en la formación didáctica de los estudiantes
Authors: Equité Jolón Veronica Lucrecia 
Published: September 2022

OBJETIVO: explicar cómo las competencias docentes inciden en la formación didáctica desde la percepción de los estudiantes de la Maestría en Docencia Universitaria de la FAHUSAC. MÉTODO: se realizó con un enfoque mixto, con alcance descriptivo y un diseño de triangulación concurrente. La muestra fue elegida de forma intencional no probabilística, se trabajó con 26 estudiantes de los Ciclos II, III y IV, así como por 8 estudiantes graduados en el 2021. RESULTADOS: reflejaron que las competencias docentes que incidieron en su formación didáctica fueron la experiencia, el ejemplo, la tolerancia, la flexibilidad y la motivación. Esto evidencia que las competencias de los docentes que inciden en la formación didáctica de los estudiantes son de tipo humano-social, predominando sobre las académicas y las administrativas. CONCLUSIÓN: desde la percepción de los estudiantes de la Maestría en Docencia Universitaria, las competencias docentes inciden en su formación didáctica de manera positiva cuando los catedráticos los motivan, les demuestran paciencia, les brindan confianza y son un ejemplo positivo de cómo realizar la docencia, también pueden incidir de manera negativa cuando generan miedo, reflejan falta de vocación, tienen poca paciencia y no realimentan el trabajo que desarrollan.
Factores familiares y psicológicos que influyen en el rendimiento de la lectoescritura
Authors: Castro Gutiérrez Vilma Celeste 
Published: September 2022

OBJETIVO: indagar sobre los factores familiares y psicológicos más frecuentemente identificados que influyen en el aprendizaje de la lectoescritura en niños y niñas de primer grado. MÉTODO: se abordó desde un enfoque cualitativo con un diseño fenomenológico y un alcance descriptivo, con fundamentación teórica y sistematización de resultados basados en entrevistas con una muestra de 20 niños y un docente.
RESULTADOS: de las entrevistas se refleja que los factores que influyen en el aprendizaje de la lectoescritura en los niños y niñas son la falta de apoyo de los padres y madres de familia a raíz del analfabetismo también existe abandono de hogar por empleo. Las situaciones a las que se enfrenta la docente dentro del aula son inasistencia a clases, desmotivación por falta de apoyo de los progenitores hacia sus hijos, problemas de aprendizaje, enfermedades virales, trabajo infantil. CONCLUSIÓN: se concluye que el padre y madre de familia influye en gran escala en el rendimiento que desempeñe el niño dentro del aula, la falta de apoyo de algunos padres de familia, producen desmotivación, inasistencia a clases, hiperactivismo, los problemas de aprendizaje se pueden dar por enfermedades virales, desintegración familiar, trabajo infantil, todo repercute a cambios conductuales en el niño.
Últimas Tendencias en el Análisis Técnico-Táctico del Voleibol de Alto Nivel. Revisión Sistemática (Latest Trends in Technical-Tactical Analysis of High-Level Volleyball. Systematic Review)
Authors: Marzano-Felisatti Joaquín Martín , Guzmán Luján José Francisco , Priego-Quesada José Ignacio 
Published: September 2022

El análisis técnico-táctico se ha convertido en una pieza clave en el rendimiento del voleibol. Por tal motivo, el objetivo de esta revisión sistemática fue profundizar en las últimas tendencias de investigación aplicadas al análisis técnico-táctico del voleibol de alto nivel. Para ello, se llevó a cabo una revisión sistemática de la literatura siguiendo los criterios PRISMA, en el mes de febrero de 2022. Las bases de datos consultadas fueron SPORTDiscus, Web of Science y Scopus. Como resultado se obtuvieron un total de 1087 artículos, de los cuales finalmente 45 formaron parte de la revisión. Se identificaron tres tipos de variables independientes relacionadas con: el contexto social (ranking, calidad del rival y localización), el contexto personal (experiencia, género y edad) y la situación de partido (temporales o espaciales, rol, resultado y modelo de juego), y cinco tipos de variables dependientes relacionadas con: las acciones de juego (saque, recepción, ataque, colocación, acciones finales y acciones intermedias), la toma de decisiones, la variabilidad, las redes de juego y la relación entre jugadores. Como conclusión, queda reflejada la complejidad y multidimensionalidad que presenta el análisis técnico-táctico del voleibol de alto nivel, siendo necesario que los cuerpos técnicos se sitúen en una visión más específica u holística del juego en función de su objeto de estudio.
Palabras clave: análisis notacional, scouting, rendimiento, deportes de equipo, competición.
Abstract. Technical-tactical analysis has become a key element in volleyball performance. For this reason, the aim of this systematic review was to deepen in the latest research trends applied to technical-tactical analysis of high-level volleyball. To this end, a systematic review of the literature was carried out following the PRISMA criteria in February 2022. The databases consulted were SPORTDiscus, Web of Science and Scopus. As a result, a total of 1087 articles were obtained, from which 45 were finally included in the review. Three types of independent variables were identified related to: social context (ranking, quality of the opponent and location), personal context (experience, gender and age) and match situation (temporal or spatial, role, result and game model), and five types of dependent variables related to: game actions (serve, reception, attack, set, final actions and intermediate actions), decision making, variability, game networks and relationship between players. In conclusion, it is proved how complex and multidimensional technical-tactical analysis of high-level volleyball is, being necessary for coaching staff to decide whether to go for a more specific or holistic analysis of the game depending on the study aims.
Key words: notational analysis, scouting, performance, team sports, competition.
Educación Física Bilingüe-AICLE a través de la enseñanza comprensiva de los juegos: análisis comparativo de la satisfacción intrínseca por edad y género (Bilingual Physical Education-CLIL through teaching games for understanding: comparative analysis of intrinsic satisfaction by age and gender)
Authors: García-Calvo Rojo Santiago , Nieto Moreno de Diezmas Esther Luisa 
Published: September 2022

El objetivo fundamental de esta investigación fue determinar el grado de satisfacción intrínseca y su variabilidad según edad y género en la Educación Física Bilingüe (EFB) implementada combinando la metodología AICLE (aprendizaje integrado de contenido y lengua) y la EC (enseñanza comprensiva) del juego. El estudio se contextualizó en un colegio bilingüe de la CAM (Comunidad Autónoma de Madrid) y el número de participantes fue n=158 (n= 85, chicos y n=73, chicas) de 3º, 4º, 5º y 6º de educación primaria. La satisfacción se evaluó utilizando el cuestionario SSI-BPE (Sport Satisfaction Instrument in Bilingual Physical Education) y con un cuestionario de respuesta abierta. Los resultados mostraron que la intervención pedagógica en inglés (AICLE-EC) impactó positivamente en la diversión, con diferencias significativas entre el pre y el post-test. El alumnado de 3º obtuvo resultados significativamente superiores al de 6º, corroborándose así la tendencia observada en estudios previos de que la satisfacción decrece con la edad. En lo que respecta al género, las chicas mostraron índices de satisfacción significativamente más altos que los chicos, lo que contrasta con los hallazgos de los estudios sobre satisfacción contextualizados en la Educación Física no bilingüe y parece indicar que la EFB contribuye a crear escenarios de aprendizaje más igualitarios.
Abstract: The main objective of this study was to ascertain the degree of intrinsic satisfaction and its variability due to age and gender in Bilingual Physical Education (BPE) implemented by combining the CLIL methodology (content and language integrated learning) and TGfU (teaching games for understanding). The study was set in a bilingual school of the CAM (Autonomous Community of Madrid) and the number of participants was n=158 (n= 85, boys and n=73, girls) from grades 3, 4, 5 and 6 of primary education. Satisfaction was evaluated using the SSI-BPE (Sport Satisfaction Instrument in Bilingual Physical Education) and a questionnaire with open-ended questions. The results showed the pedagogical intervention in English (CLIL-TGFU) positively impacted in amusement, with significant differences between the pre and post-test. Students in grade 3 obtained significantly higher results than in grade 6, thereby corroborating the trend observed in previous research that satisfaction decreases with age. Regarding gender, girls showed significantly higher satisfaction rates than boys, which contrasts with the findings of studies on satisfaction set in non-bilingual PE settings and seems to suggest that BPE contributes to creating more egalitarian learning scenarios.