bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-cancer Potential of Pleurotus Mushroom: Detailed Insight on the
Potential Bioactive Molecules, In vitro-In vivo Studies, and Formulation
Authors: Sahu Alakh N. , Shreya Singh , Jain Shreyans K. , Guru Santosh K. 
Published: May 2022

Abstract:
Early mushrooms were categorized under functional food/ nutritional food. However, later on, an increasing number of scientific studies strongly support their role in disease prevention and suppression or remission of a diseased state. Mycotherapy of cancer, a new promising field, can deal with anti-cancerogenic agents derived from mushrooms. Rich in nutritive value, undemanding cultivation conditions, and with an army of health-promoting bioactive molecules, collectively makes Pleurotus mushroom ideal for a researcher to investigate the anticancer potential. The present review is a literature survey on electronic search by two database search engines: Science direct and Pub med on anticancer potential of Pleurotus species until 2021. This data profiling will fast track information regarding the in vitro and in vivo anticancer activity of different types of Pleurotus species, along with identifying the bioactivemolecules responsible for anticancer potential with their underlying mechanism of action. Resultant findings from the electronic search revealed that till 2021, nearly 13 species of Pleurotus mushroom have been studied as anticancer potential. The biomarkers responsible for activity are mostly higher molecular weight molecules, comprising polysaccharides, polypeptides, proteins, lectins, and enzymes. The lower molecular weight molecules like terpenoids, sterols, and phenolic compounds are less explored and untapped. The main underlying mechanism for the anticancer activity of Pleurotus mushrooms is the induction of the mitochondria intrinsic pathway. For anticancer, Pleurotus mushrooms are widely formulated as metal nanoparticles. Altogether, with this detailed insight may impart the researcher a path to be addressed, thus driving mass attention to identify novel,effective, and safer anticancer potential biomarker.
The Factors Related to Unwanted Pregnancy Among Pregnant Women: A
Case-control Study in Western Iran
Authors: Roshanaei Ghodratollah , Khazaei Salman , jenabi Ensiyeh 
Published: May 2022

Aims:
This study aimed to investigate factors affecting unwanted pregnancy in Hamadan.

Background:
Various factors affect the occurrence and extent of unwanted pregnancies.

Methods:
The present case-control study was performed on 901 pregnant women admitted to comprehensive
health centers in Hamadan in 2020. The case group included women with unwanted
pregnancies and the control group consisted of women who became pregnant in a preplanned manner.
Data were collected from the samples using a checklist. Data were analyzed with SPSS24 at a
significance level of 5%.

Results:
This case-control study was conducted on 455 mothers in the case group (with unwanted
pregnancies) and 456 samples in the control group. The results of the logistic regression model indicated
that the history of abortion, education, stillbirth history, history of contraceptive use, history of
unwanted pregnancy, marital satisfaction, emotional relation with the spouse, spouse's opinion about
contraception method, age, and the first pregnancy age were the predictors of unwanted pregnancy.

Conclusion:
To prevent unwanted pregnancies, it is recommended to start the correct training of
family planning methods from high school and pursue it continuously after marriage, during pregnancy,
and postpartum care.
Is Surgery Worthwhile in Locally-advanced NSCLC Patients with Persistent
N2-disease After Neoadjuvant Therapy?
Authors: Lococo Filippo , Chiappetta Marco , Sassorossi Corolina , Nachira Dania , Evangelista Jessica , Ciavarella Leonardo Petracca , Congedo Maria Teresa , Porziella Venanzio , Boldrini Luca , Larici Annarila , Bria Emilio , Margaritora Stefano 
Published: May 2022

Aims:
To explore the long-term survival in lung cancer patients with persistent mediastinal lymph nodal disease after neoadjuvant followed by surgical resection and to analyse prognostic fac-tors in this specific subset of patients

Background:
Surgery in non-small-cell lung cancer (NSCLC) patients with N2-disease after neoad-juvant therapy (NAD) has been debated and has been even more questioned with the advent of im-munotherapy.

Objective:
Describe long-term results of a multimodal approach in locally-advanced NSCLC patients with persistence of N2-disease and identify prognostic factors to target the strategy of care.

Method:
We retrospectively reviewed data of 121 consecutive Stage IIIA-N2 NSCLC patients who underwent NAD (chemoradiotherapy or chemotherapy) from 01/00 to 12/19, focusing our analysis on 37 patients with persistent N2s status after surgery. Kaplan-Meier and Cox regression analysis explored the associations between mortality and potential risk factors.

Result:
The 5-year survival was 29.8%. Cox regression analysis suggested that young age (HR=0.98, C.I.95%: 0.97- 1.00; p=0.062), male sex (HR=3.8,C.I.95%:1.06-13.73;p=0.04), and adjuvant therapy (HR=6.81,C.I.95%:0.96-53.94;p=0.06) influenced long-term outcomes in these patients.

Conclusion:
We herein observed suboptimal long-term results in this NSCLC patient subset, and, considering emerging results adopting immunotherapy following chemoradiotherapy, surgery should be carefully considered in very selected cases (young and clinically fit patients) and combined with adjuvant therapy after surgery.
Mapping of New Pharmacological Alternatives in the Face of the
Emergence of Antibiotic Resistance in COVID-19 Patents Treated
for Opportunistic Respiratory Bacterial Pathogens
Authors: Santos Anamaria Mendonça , Santos Mariana Mendonça , Nascimento Júnior José Adão Carvalho , Brito João Rafael Lisboa Rêgo , de Araújo Andrade Tatianny , Frank Luiza Abrahão , Serafini Mairim Russo 
Published: May 2022

Background:
The increase in bacterial resistance against antibiotics is
thought to be another type of pandemic after COVID-19. Emergency treatment based on
antibiotics is a major influence in increasing this resistance. Bacteria, such as Klebsiella
pneumoniae, are the most affected by the indiscriminate use of antibiotics, since they
are resistant to most antibiotics currently available on the market.

Objective:
This review aimed to evaluate patents of new drugs and formulations, for the
treatment of infections caused by Klebsiella pneumoniae.

Methods:
The present patent review was carried out through a specialized search database
Espacenet. The selection was based on the criteria of patents published from 2010
to May 2021, in any language, and containing the keywords in title or abstract. Also, a
research was performed on the PubMed database, using the inclusion criteria.

Results:
Twenty-two patents were selected for the analysis according to the aim of the
study. The advance of new patents has been mostly observed in the World Intellectual
Property Organization, China, and United States. The results showed that the main approach
was the drug association, followed by drug carriers, new isolated products, and
vaccines.

Conclusion:
It has been observed that few studies use new drug alternatives for the
treatment, probably due to the higher cost of the development and lack of investments.
The effectiveness and safety of these therapies depend on the acceptance, the correct
prescription, and rational use of medicines. Therefore, this review can further develop
new treatments as alternatives against Klebsiella pneumoniae and pneumonia caused by
it.
Fabrication and Self-cleaning Performance of RGO/(Si, Mo)-codoped TiO2
Thin Films for Architecture Environment Decontamination Application
Authors: He H.-Y. , Dang W. 
Published: May 2022

Background:
Self-cleaning is a potential technique in architecture environmental decontamination.

Objective:
We report t The fabrication and self-cleaning property enhancement of the TiO2 hybridizing reduced graphene oxide (RGO) and codoping Si and Mo.

Methods:
The films were deposited by a sol-gel dip-coating process. The self-cleaning properties were characterized by photocatalytic activity, photoinduced super hydrophilicity, and conductivity.

Results:
Incorporating RGO provided an efficient interface-induced effect, and doping Si and Mo enhanced this effect.

Conclusion:
Thus, the hybrid films showed remarkably enhanced self-cleaning performances. The transparency of the films also did not affected by RGO shown high transparent when RGO is added in the condition of the doping Si and an appropriate amount of Mo.
Malnutrición en una población de escolares en Santiago, República Dominicana
Authors: Ramos García Samuel , Gutiérrez Anthony , Cruz Juan , Díaz Alexander , Corona Karoline , Gómez Emanuella , Gómez Karina , Ramos Ureña Samuel Milcíades , García Raisa 
Published: May 2022

Introducción: la malnutrición infantil representa uno de los problemas de salud pública más importantes de la República Dominicana (RD) y el mundo. A pesar de esto, actualmente, no existen estudios en la RD que describa el estado nutricional en los niños de la escuela primaria.
Material y métodos: este estudio transversal describió las principales variables antropométricas en niños de 1ero a 6to de primaria en Santiago, RD, además de determinar la relación existente entre la antropometría y variables sociodemográficas.
Resultados: de los 2,271 estudiantes estudiados, la media del peso fue 33,2 ± 11,4 kg, la talla fue 1,36 ± 0,13 m. La media del percentil fue 65,33 %. El 3.92 % (n=89) estuvo en bajo peso, el 17.57 % (n=399) estuvo en sobrepeso y el 22.94 % (n=521) estuvo en obesidad.
Conclusión: el sobrepeso y la obesidad infantil fueron los trastornos más comunes en zonas rurales y urbanas, y tanto en centros privados como públicos.
Políticas públicas y acceso al hábitat en Cipolletti (2003-2015): política urbana y política represiva en la criminalización de tomas de tierras
Authors: Giaretto Mariana 
Published: May 2022

En este artículo abordamos los modos de intervención del Estado en la problemática de acceso al suelo urbano por parte de los sectores populares en la ciudad de Cipolletti, Río Negro, durante la posconvertibilidad. Analizamos algunas de las principales políticas públicas orientadas a la planificación urbana, a la producción de suelo urbano y vivienda, de acceso a crédito y también políticas de erradicación y relocalización de asentamientos informales.
Además del análisis de diversas fuentes documentales, realizamos entrevistas a funcionarixs, referentes del mercado inmobiliario y referentes de tomas de tierras, que nos permitieron advertir que se despliegan sistemáticamente procesos de criminalización contra quienes toman tierras para habitarlas. De este modo, la criminalización de las tomas de tierras se presenta como reverso de la política urbana.
A pesar de esta combinación entre política urbana y política represiva, la mitad de los barrios de la ciudad permanecen bajo condiciones de precariedad habitacional. Periódicamente surgen nuevas tomas, revelando que las políticas públicas adoptan la forma de un proceso de ensayo y error bajo una racionalidad acotada, que solo posibilita salir del paso sin lograr solucionar el problema del acceso a la vivienda y a la ciudad.
A Collation of the Three Published Versions of Thornton Wilder's “Our Town”
Authors: BUCKER PARK 
Published: May 2022

Abstract
Our Town (1938), the most performed American play, first appeared in print in March 1938, published by Coward McCann one month after the play's Broadway debut. This book, set in type before rehearsals began, represents Thornton Wilder's original version of the play. Wilder extensively revised the play during production while working with producer-director Jed Harris. The production's prompt script became the basis for the Samuel French acting edition, first available in April 1939. In 1957, Wilder again revised his text for his collection Three Plays (Harper & Row). This version restores many of the cuts made from his original version, makes hundreds of minor and several major alterations, and adds some new material, marking it as the author's third published version. A collation of these three versions of Our Town documents Wilder's creative process, the many changes necessary in transferring a script to a performance, and the play's evolving themes.
Terror in Tennessee: Oliver W. Harrington on the Race Riot in Columbia
Authors: INGE M. THOMAS 
Published: May 2022

Abstract
Oliver Wendell Harrington, popular black cartoonist and journalist, spent several years in the 1940s managing public relations for the NAACP. During that period, he researched and wrote a pamphlet decrying events in February of 1946 in Columbia, Tennessee, in which the black community was brutally terrorized over a minor disagreement. The text of the pamphlet is reprinted here for the first time as an addition to Harrington's known writings and as an example of the racism then inherent in the American South.
Revisiting the “Hawthorne Problem”
Authors: CODY DAVID C. 
Published: May 2022

Abstract
Samuel Chase Coale's The Entanglements of Nathaniel Hawthorne: Haunted Minds and Ambiguous Approaches is a well-written and wide-ranging survey (intended for a broad audience) of what is now more than a century's worth of literary criticism and formal literary scholarship relating to the works of Nathaniel Hawthorne, still perhaps the most insistently canonical of all American authors. For Coale, “entanglement” (a term borrowed from the lexicon of quantum physics) goes far to explain both the richness and the confused (and often confusing) nature of the received scholarly tradition, since Hawthorne's intertwined and interpenetrating allegories, dualities, and polarities help to account for the “complicated and labyrinthine” nature both of the work itself and of the many scholarly responses that it has engendered.
Getting the Joke in “Of Being Numerous”: George Oppen as Heir to Walt Whitman's Public Poetics
Authors: MILLER MATT 
Published: May 2022

Abstract
Although George Oppen once claimed that “Whitman has been no use to me,” a review of Oppen's poetry, letters, daybooks, and interviews reveals that Whitman was central to Oppen's poetics and to his most celebrated poem, “Of Being Numerous.” Using archival materials and recently published interviews, this essay provides a comprehensive overview of Oppen's engagement with Whitman, highlighting the sophistication and complexity of his response and addressing what Oppen meant when he described the conclusion to “Of Being Numerous” as in part “a joke on Whitman.” Using him variously as foil, icon, compatriot, and source text, Oppen presents a version of Whitman at odds with both the critical responses of previous modernists and the more enthusiastic interpretations of Oppen's contemporaries in the 1950s and 1960s.
The New Emerson Canon
Authors: COLE PHYLLIS 
Published: May 2022

Abstract
This review-essay salutes the completion of the final volume (Uncollected Prose Writings) in the fifty-year project of editing Ralph Waldo Emerson's Collected Works while also reflecting on editorial principles that result in omissions from a newly definitive representation of the author. Since the 1970s, all editors have followed the principles of Walter Greg and included only texts for which there was “initial coherent intent” by Emerson. With his increasing dementia in old age, however, such intent was construed by a team of others, yet collaborative texts have been omitted from this volume in particular. Detailing the gains of Uncollected Prose Writings, the review-essay also argues for the authenticity of selected missing texts, in particular the lecture “Mary Moody Emerson” and the Memoirs of Margaret Fuller Ossoli. Further editing work may be possible on these, following the collaborative, intertextual (often digital) models proposed since Greg's time by Jerome McGann.
Reading Margaret Fuller
Authors: FLEISCHMANN FRITZ 
Published: May 2022

Abstract
A comparative review of John Matteson's The Lives of Margaret Fuller: A Biography (2012) and Megan Marshall's Margaret Fuller: A New American Life (2013), this review essay addresses the problems that these excellent new biographies, aimed at broader audiences, seek to remedy: Why does a figure of such wide influence and intellectual significance continue to dwell in relative obscurity? And why does her life story continue to overshadow her work?
The Transcription Factor YY1 is Essential for Normal DNA Repair and Cell Cycle in Human and Mouse β-cells
Authors: Peçanha Flavia Letícia Martins , Jaafar Rami , Werneck-de-Castro Joao Pedro , Apostolopolou Charalampia-Christina , Bhushan Anil , Bernal-Mizrachi Ernesto 
Published: May 2022

<p> </p>
<p>Identifying the mechanisms behind the b-cell adaptation-to-failure is important to develop strategies to manage type 2 diabetes (T2D). Using <em>db/db</em> mice at early stages of the disease process, we took advantage of unbiased RNAseq to identify genes/pathways regulated by insulin resistance in b-cells. We demonstrate herein that islets from 4-week-old non-obese and non-diabetic leptin-receptor deficient <em>db/db</em> mice exhibited downregulation of several genes involved in cell-cycle regulation and DNA repair. We identified the transcription factor Yin Yang 1 (YY1) as a common gene between both pathways. The expression of YY1 and its targeted genes was decreased in the <em>db/db</em> islets. We confirmed the reduction in YY1 expression in b-cells from diabetic <em>db/db</em> mice, mice fed high fat diet (HFD) and individuals with T2D. ChIP-seq profiling in EndocBH1 cells, a human pancreatic b-cell line, indicated that YY1 binding regions regulate cell-cycle control, DNA damage recognition and repair. We then generated mouse models with constitutive and inducible YY1 deficiency in b-cells. YY1 deficient mice developed diabetes early in life due to b-cell loss. b-cells from these mice exhibited higher DNA damage, cell cycle arrest and cell death as well as decreased maturation markers. Tamoxifen-induced YY1 deficiency in mature b-cells impaired b-cell function and induced DNA damage. In summary, we identified YY1 as a critical factor for b-cell DNA repair and cell-cycle progression. </p>
Dukungan Kualitas Input Siswa, Komitmen Guru, Sarana dan Prasarana terhadap Kemandirian Belajar Kimia di SMK
Authors: Pratiwi Kartika , Suyatmini S 
Published: May 2022

Penelitian ini bertujuan untuk menganalisis dan menguji dukungan: 1) kualitas inputsiswa, komitmen guru, dan sarana prasarana, 2) kualitas input siswa, 3) komitmenguru dan 4) sarana prasarana terhadap kemandirian belajar kimia di SMK Pancasila1 Wonogiri. Penelitian ini merupakan jenis penelitian kualitatif dengan desainkorelasional menggunakan proporsional random sampling yang populasinya seluruhsiswa kelas XI, sebanyak 502 siswa. Data diambil melalui angket tertutup. Teknikpengumpulan data dibantu dengan observasi dan wawancara. Teknik Analisis Datamenggunakan Uji Regresi Linear Ganda. Hasil penelitian ini adalah 1) DukunganKualitas Input Siswa, Komitmen Guru, dan Sarana dan Prasarana secara serentakberpengaruh terhadap Kemandirian Belajar Siswa yaitu dipengaruhi adanya sarana prasarana, dalam hal ini perangkat lunak komputer, 2) Dukungan Kualitas Input Siswaberpengaruh signifikan terhadap Kemandirian Belajar Siswa yang bermakna jikasumber daya manusia dapat efektif dan efisien maka suatu organisasi akan menjadimaju, 3) Dukungan Komitmen Guru berpengaruh signifikan terhadap KemandirianBelajar Siswa yaitu mempengaruhi kinerja salah satu wujudnya muncul kemandirianbelajar siswa dan 4) Dukungan Sarana dan Prasarana berpengaruh signifikan terhadapKemandirian Belajar Siswa yaitu mendukung metode guru dalam pembelajaran yangsalah satu tujuannya membangkitkan sifat kemandirian belajar siswa.
Perancangan Sistem Informasi Peminjaman dan Pengembalian Barang Laboratorium di SMK Negeri 1 Solok Selatan
Authors: Samudra Ami Anggraini , Mary Thomson , Susilawati Feni 
Published: May 2022

Recording at the SMK N 1 Solok Selatan laboratory has been carried out by writing all transactions on paper or in folio notebooks. The difficulty in this recording process is in terms of data storage and retrieval. In addition, a manual filing system can cause some archival data to be lost or tucked away in one place and also cause some items to be lost, and labor officers still have difficulty managing reports of labor goods with frequent duplication of processing item data, and difficulties in updating item data. according to certain conditions. From this problem, an information system for borrowing and returning laboratory goods was designed using the Unified Modeling Language (UML) model and the Software Development Life Cycle (SDLC) method which in this model has several stages, namely the planning stage, the analysis stage, the design stage, the implementation stage, the testing phase and the maintenance stage. This information system for borrowing and returning laboratory goods is carried out by testing Blackbox testing and in accordance with this test system can facilitate the process of borrowing and returning goods between members and labor officers when borrowing and returning goods, as well as labor officers with the head of labor in the problem of borrowing reports and return of goods. Keywords: Information systems, Unified Modeling Language (UML), Software Development Life Cycle (SDLC),Laboratorium.
Gambaran Psikologis Anak Tuna laras
Authors: Prasrihamni Mega , Supena Asep , Intika Tiurida 
Published: May 2022

Artikel ini bertujuan untuk menentukan kondisi psikologis anak-anak penyandang cacat. Menurut Tamsik Udin dan Tejaningsih, anak penyandang disabilitas adalah anak yang mengalami kendala dalam perkembangan sosial dan emosionalnya, sehingga dikukuhkan melalui perilaku norma hukum, sosial, agama yang berlaku di lingkungannya dengan frekuensi yang cukup tinggi. Artikel ini menggunakan pendekatan deskriptif kualitatif dengan metode studi kasus. Subjek berjumlah 4 orang. Pengumpulan data dilakukan dengan cara observasi, wawancara, dokumentasi dan penyediaan Daftar Periksa Masalah (DCM). Hasil penelitian menunjukkan bahwa anak-anak penyandang disabilitas mengalami ketidakstabilan emosional sehingga ada kendala dalam berperilaku baik di masyarakat. Hambatan untuk perkembangan sosial pada anak-anak penyandang disabilitas ditunjukkan oleh kesulitan berteman. Ini karena mereka tidak dapat beradaptasi dengan kelompok yang lebih luas dan kesadaran sosial mereka sangat rendah dan mereka lebih suka bermain sendiri. Pendekatan yang lebih baik diperlukan untuk anak-anak penyandang disabilitas seperti pendekatan dalam bimbingan karena akan sangat mempengaruhi kehidupan di masa depan
Yersiniosis: a forgotten mimicker and confounder of Crohn’s disease
Authors: Zawada Iwona , Dąbkowski Krzysztof , Marlicz Wojciech , Starzyńska Teresa 
Published: May 2022

Abstract
Yersiniosis is a zoonosis caused by the Yersinia bacterium. The route of infection is most commonly oral and is caused by consumption of Yersinia-contaminated food. The clinical presentations of chronic yersiniosis are abdominal pain, diarrhea, relapsing arthritis, and skin lesions, that is, nodular erythema. The diagnosis is based on culture-dependent identification of Yersinia in stool, positive serologic test results, or molecular techniques. The treatment of choice is combination antibiotic therapy. Mild forms of the disease do not usually require treatment. Yersiniosis frequently mimics or confounds other chronic intestinal and extraintestinal inflammatory conditions, particularly Crohn’s disease. Therefore, diagnosis of yersiniosis may be a challenge for medical practitioners. Not including Yersinia infection in the differential diagnosis of abdominal symptoms can lead to an incorrect diagnosis and inappropriate treatment. This review summarises the current knowledge of Yersinia enterocolitica and pseudotuberculosis infection, with special focus on differential diagnosis between this infection and Crohn’s disease.