bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the improvement of serological indexes in patients with diabetic nephropathy and hypertension using Valsartan combined with Nifedipine controlled-release regimen
Authors: Cai Lili , Zhu Hailli 
Published: June 2022

Objective: To investigate the effect of valsartan combined with nifedipine controlled-release Tablets on diabetic nephropathy (DN) patients with hypertension.
Methods: The clinical records of 80 DN patients with hypertension registered in our hospital from April 2020 to April 2021 were collected. The records showed that 38 patients were treated with oral nifedipine controlled-release tablets (control group) and 42 - with oral valsartan combined with nifedipine controlled-release tablets (observation group). The improvement of serological indexes after treatment was compared and analyzed between the two groups.
Results: After treatment, the levels of fasting blood glucose (FBG), systolic and diastolic blood pressure, bone oligomeric matrix protein (COMP), thrombin regulatory protein (TM) and Microalbumin (mALB) in the observation group were lower than those in the control group (P<0.05), while the level of angiopoietin-1 (Ang-1) was higher than those in the control group (P<0.05). After the treatment, the levels of homocysteine (Hcy), Cystatin C (CysC) and transforming growth factor β1(TGF-β1) in the observation group were lower than those in the control group (P<0.05). The levels of adiponectin (APN), aldosterone (ALD) and gastric growth promoting factor (ghrelin) in the observation group after the treatment were lower than those in the control group (P<0.05).
Conclusions: A combination of valsartan and nifedipine controlled-release tablets in DN patients with hypertension can effectively control blood glucose and blood pressure, improve the serological indexes such as COMP, TM, mAlb, Ang-1, Hcy, CysC, TGF-β1, APN, ALD and ghrelin, and potentially reduce and delay renal function damage.
doi: https://doi.org/10.12669/pjms.38.6.5871
How to cite this:Cai L, Zhu H. Analysis of the improvement of serological indexes in patients with diabetic nephropathy and hypertension using Valsartan combined with Nifedipine controlled-release regimen. Pak J Med Sci. 2022;38(6):---------. doi: https://doi.org/10.12669/pjms.38.6.5871
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The Latest News for May 2022 All You Need to Know on Monkeypox
Authors: Makkar Dheeraj 
Published: June 2022

Monkeypox virus was named so because of its detection in monkeys in 1958. It belongs to the same family as smallpox and chickenpox viruses. There had been numerous outbreaks of this malady initially in the African continent and other parts of the world. The simultaneous spread in nineteen countries in 2022 has raised some serious concerns.
Monkeypox is no more a rare disease and has the potential for bioweapon use. We discuss the various ways to prevent its spread, treatment options available, diagnosis, and differentiation from other closely related diseases. We also discuss if the present outbreak could be a bioattack or if this disease is here to stay.
The literature suggests that we can effectively manage Monkeypox because of the availability of drugs and vaccination against smallpox. There is also a need for active surveillance against the new resistant recombinant viral strains. The possibility of this outbreak being a bioattack seems remote, although there are questions about the transmission which still need to be answered.
The Development of Corporate Entrepreneurship among Emerging Economy SMEs: Insights from Both Institutional and Contingency Theory
Authors: Mustafa Michael 
Published: June 2022

Abstract
How do emerging economy SMEs develop Corporate Entrepreneurship (CE)? Emerging economies represent different institutional contexts to those found in developed economies. Currently our understanding of CE and its emergence is rooted in Western-based assumptions. Consequently, our understanding of the inter-relationship between the emerging economy institutional environments and the SME environment and how they shape corporate entrepreneurial process remains lacking. In response to such gaps in our understanding, this study draws on both Institutional and Contingency theories to explore how CE is developed among African SMEs. Drawing on evidence from four indepth case studies of Kenyan SMEs, our findings reveal a complex process wherein elements of the Kenyan institutional environment shape the internal organization and CE related activities of Kenyan SMEs. Our study extends and enriches previous models of CE and deepen our understanding of how and why context matters for CE.
Socioeconomic burden of orthodontic treatment: a systematic review
Authors: Ghonmode Sumeet , Shrivastava Sunita , Kadaskar Ashita R. , Bapat Salil 
Published: June 2022

Objective. The relationship between Socio-Economic Status (SES) and the factors that may play a role in orthodontic treatment demand and uptake have not been explored. Such information is needed for better planning of orthodontic services and to ensure that health care is provided equally among all social classes. The objective of this systematic review was to find out whether socioeconomic status affects the treatment needs of orthodontic patients.
Methods. Literature search was done using Medical Subject Heading terms (MeSH) in PubMed, LIVIVO, Google Scholar, and EbscoHost from 1 January 1965 to 1 August 2021. All cross-sectional studies were included. Both male and female participants were included in the review. The quality of assessment for the included studies was evaluated independently by two reviewers using “The Jonna Briggs Institute” tool (JBI) for cross-section studies. The Cochrane Collaboration’s tool was modified and used for assessing the risk of bias and risk of summary.
Results. A total of 704 articles were found. The relevant database searches were PubMed 259 articles, followed by EbscoHost 280, LIVIVO 145, and Google Scholar 20 articles. A final of 10 cross-sectional studies were included in the review.
Conclusion. The reviewers found evidence that parents ultimately decide whether the child will undergo treatment, possibly depending on their financial situation.
The quality of life after cleft lip and palate surgery
Authors: Opriș Daiana , Băciuț Grigore , Bran Simion , Dinu Cristian , Armencea Gabriel , Opriș Horia , Mitre Ileana , Manea Avram , Stoia Sebastian , Tamas Tiberiu , Barbur Ioan , Băciuț Mihaela 
Published: June 2022

Background and aims. Labio-maxillo-palatal clefts represent one of the most common congenital malformations, which manifests through aesthetic, functional and psycho-social alterations. The long course of multidisciplinary treatments represent a psycho-emotional and financial burden for both the patient and his family, being an important factor in the complex management of these patients.
The study aims to assess the quality of life of parents of children with clefts and the psychosocial impact on the family and society.
Methods. The study included 40 subjects who met the inclusion criteria for this study. Following patient informed consent and the approval of the ethics committee, the data were collected by applying the quality-of-life evaluation questionnaire. The evaluation was performed using the Likert scale (1 - not at all to 5 - very satisfactory), and the data were statistically processed.
Results. Most of the questionnaires were completed by the mother, who accompanied the child to the regular check-up; 58% of parents believe that their social life is not affected by having a child with a cleft, and 83% say that interfamilial relationships have not been affected. Most parents consider that the postoperative result was very good, which led to improved psycho-social integration of the child.
Conclusions. The study confirmed an acceptable quality of life for the children’s parents, which was not influenced by the family presence of a child with a cleft. At the same time, the excessive care of the parents for the child with the cleft was confirmed. The postoperative improvement of the aesthetic aspect led to a much better psycho-emotional integration of the child in the society.
Microbiome modulation in the prevention and management of colorectal cancer: a systematic review of clinical interventions
Authors: Fratila Teodora D. , Ismaiel Abdulrahman , Dumitrascu Dan L. 
Published: June 2022

Introduction. The role of probiotics/prebiotics in modulating the procarcinogenic effects of microbiota have been studied with inconclusive results. This systematic review aimed to identify the role of several studied interventions on the gut microbiota modulation in humans for the prevention and management of colorectal cancer (CRC).
Methods. We conducted a systematic search using PubMed and Cochrane Central electronic databases, identifying clinical studies published within the last 20 years. We performed a qualitative analysis of eligible studies included in our review on each of the 4 investigated topics: CRC potential biomarkers, dietary interventions, probiotic administration in non-surgical and surgical patients, respectively.
Results. A total of 54 studies involving healthy volunteers, in addition to colorectal adenoma and CRC patients were included in our qualitative synthesis. We were able to identify bacterial signatures of CRC including Fusobacterium nucleatum and Clostridium butyricum. Moreover, dietary supplementation with oligosaccharides or fibers increased short chain fatty acid-producing bacteria levels, thus inhibiting tumorigenesis. Furthermore, we have confirmed that Lactobacilli and Bifidobacterium intake modulates gut microbiota towards tumor suppression. We have also showed that probiotic intake around colectomy significantly reduces complications.
Conclusions. Bacterial metabolism is strongly linked with colonic carcinogenesis and influenced by diet. Probiotics and prebiotics can act as microbiota modulators, suppressing epithelial proliferation and reversing DNA toxicity. As adjuvants to surgery or chemotherapy, Lactobacilli and Bifidobacteria decrease complications. Improved outcomes in CRC patients can possibly be achieved through future research directed towards the benefits of bacterial agents as tumor suppressors or as treatment of oncological therapy resistance.
Is C-section a risk factor for early onset irritable bowel syndrome?
Authors: Galica Adelina Nicoleta , Grabocka Erisa , Dumitrascu Dan Lucian 
Published: June 2022

Background and aim. There are controversial data in literature regarding the influence of abdominal and pelvic surgery on the onset of gastrointestinal symptoms. The aim of this study was to assess whether women who had a C-section (cesarean section) are more likely to develop irritable bowel syndrome (IBS) early after delivery than those who have given birth naturally.
Method. A cross-sectional study investigated women who had undergone C-section and were compared with a control group of women who had natural delivery. Data were obtained from Maternity Ward of Korce Hospital, in Albania. We conducted a telephone interview based on a questionnaire containing items to diagnose IBS based on the Rome IV criteria. The interviews were conducted 9 to 12 months after delivery.
Results. The prevalence of IBS in both groups taken together 4.6%. In the C-section group, prevalence of IBS was 4.3%, while in the control group it was 5.2%. All the patients with IBS had subtype with predominance of constipation. The RR 0.814 (CI 95%, 0.1423-4.66) does not confirm the hypothesis that C- section may induce early onset of IBS more often than natural birth.
Conclusion. The prevalence of IBS was (4.6%), within the known range of the Rome Foundation Global Study. Delivery by C-section does not have a role in developing IBS symptoms more than delivery by natural way in this group of Albanian women.
Resección de osteoma osteoide vertebral asistida por planificación 3D. Presentación de un caso
Authors: Lombardo Ernesto , Velez Manuel , Verger Sergio 
Published: June 2022

La localización vertebral de una lesión compatible con un osteoma osteoide requiere, muchas veces, su resección en bloque marginal mediante cirugía. El objetivo de este artículo es informar sobre el uso de la tecnología en impresión 3D para desarrollar guías de corte y así lograr una resección segura y completa de un osteoma osteoide de L1. Presentamos a un varón de 13 años, operado de un osteoma osteoide de L1 y detallamos la planificación preoperatoria con asistencia de la tecnología 3D, la técnica quirúrgica mediante guías de corte impresas y un modelo real de la columna lumbar y el control posoperatorio.
Conclusiones: Ante la indicación de cirugía para una lesión compatible con osteoma osteoide en la columna debe decidirse entre la posibilidad de resección intralesional abierta o percutánea y la resección marginal en bloque. Para localizar la lesión durante la cirugía, se utilizan diferentes métodos. En nuestro Servicio, estamos utilizando la tecnología 3D para la planificación preoperatoria de múltiples enfermedadestraumatológicas agudas y las secuelas. Esto nos permite una mayor precisión y seguridad en la identificación de los márgenes de resección intraoperatoria, reduciendo, al mínimo, la extracción de tejidos sanos y evitando la inestabilidad posoperatoria.
Fascitis plantar: análisis de opciones terapéuticas
Authors: Iglesias Matías , Sperone Enzo , Macklin Vadell Alberto , Bigatti Andrés 
Published: June 2022

El objetivo de este artículo es analizar las distintas opciones de tratamiento. Se realizó una encuesta virtual a diferentes traumatólogos especialistas en pierna y pie, sobre el tratamiento de la fascitis plantar. Los resultados fueron variados, lo que demuestra que no hay una respuesta concreta ante el tratamiento crónico.
Conclusiones: La fascitis plantar es un cuadro doloroso frecuente. Su origen es desconocido, pero está relacionada con múltiples factores. Se han recomendado muchas modalidades terapéuticas, como fármacos, fisioterapia, ortesis y cirugía, pero no existe un estudio que analice la eficacia de cada una de ellas por separado ni que confirme categóricamente su utilidad.
Tumor mesenquimático fosfatúrico de pelvis: abordaje multidisciplinario
Authors: Cullari Leonardo Matías , Senes Sebastián , Taleb Juan Pablo , Fita Ignacio , Sarmiento Pablo Daniel 
Published: June 2022

El tumor mesenquimático fosfatúrico es una entidad clinicopatológica sumamente infrecuente. Además de provocar dolor óseo insidioso y polimialgias, se acompaña de alteraciones del metabolismo fosfocálcico de difícil manejo clínico. El abordaje multidisciplinario resulta la clave del éxito en esta enfermedad. Presentamos una paciente de 52 años de edad con antecedente de tumor mesenquimático fosfatúrico en la hemipelvis derecha con extensión a la cadera homolateral de 10 años de evolución. Clínicamente presentaba osteomalacia oncogénica (hipofosfatemia e hiperfosfaturia) que no se corregía, pese a un agente de últimageneración, el burosumab, un inhibidor del factor de crecimiento fibroblástico 23, que aumenta la tubular renal de fosfatos. En un comité multidisciplinario, se decidió la resección con márgenes oncológicos y se logró una mejoría clínica franca. Comunicamos este caso, debido a que es un cuadro infrecuente
Fracturas metafiso-diafisarias de radio distal en adolescentes: estudio comparativo entre fijación percutánea con clavijas y clavos elásticos de titanio
Authors: Ferreyra Andrés , Allende Felicitas , Sánchez Benítez Juan Emiliano , Gramajo Franco , Damiguella Bruno , Allende Victoria , Masquijo Julio Javier 
Published: June 2022

Objetivo: Comparar los resultados y las complicaciones entre la fijación percutánea con clavijas (FPC) y el enclavado endomedular elástico (EEE).
Materiales y Métodos: Se evaluaron las radiografías para determinar deformidades angulares en la consolidación. Se usó el sistema de Clavien-Dindo adaptado para clasificar las complicaciones.
Resultados: El grupo A (FPC) incluyó a 17 pacientes y el grupo B (EEE), a 19. La edad promedio era de 12.5 ± 1.6 años y el seguimiento promedio fue de 27.6 ± 16.6 meses. Los pacientes con EEE requirieron menos tiempo de inmovilización (2.8 ± 1.8 vs. 5.9 ± 1.3 semanas, p 0,00029). Un paciente de cada grupo tuvo una angulación >10° en la consolidación. La tasa de complicaciones fue mayor en el grupo A (18% vs. 5,3%, p 0,27). En el grupo A, hubo 2 complicaciones tipo III (pérdida de corrección) y 2 tipo II (infección y granuloma). Un paciente del grupo B presentó una complicación tipo I (prominencia del implante). Dieciséis pacientes del grupo B se sometieron a una segunda cirugía para extraer el implante. Dos del grupo A requirieron revisión de la fijación por pérdida de alineación.
Conclusiones: Ambas técnicas son eficaces para estabilizar fracturas metafiso-diafisarias de radio distal en adolescentes. El EEE tiene la ventaja de una inmovilización más corta y menos complicaciones, pero es más caro y requiere otra cirugía para extraer el implante. La FPC no requiere de anestesia para extraer el implante, aunque sí una inmovilización más prolongada y la tasa de complicaciones es más alta.
Comparación entre cirugía asistida por navegación y cirugía convencional en el reemplazo total de rodilla
Authors: Pace Agustín , Estrada Matías , Ruggieri Eduardo Andrés 
Published: June 2022

Introducción: El reemplazo total de rodilla es el tratamiento de elección en los estadios finales de la patología degenerativa articular; su duración depende, en gran medida, de la alineación, el posicionamiento y la estabilidad de la articulación. El objetivo de este estudio fue comparar el eje mecánico del miembro inferior medido por telemetría, después de un reemplazo total de rodilla asistido por navegación o con técnicas convencionales, realizado por el mismo cirujano y con la misma prótesis. Se evaluó también el grado de satisfacción de los pacientes sometidos a este procedimiento y su posible variación entre estas dos técnicas.
Materiales y Métodos: Estudio retrospectivo, comparativo, observacional, descriptivo de 200 pacientes sometidos a un reemplazo total de rodilla, divididos en dos grupos: grupo A (100 pacientes) con prótesis Columbus® colocada con el sistema de navegación OrthoPilot® y grupo B (100 pacientes), con la misma prótesis colocada con técnica convencional. Se realizaron telemetrías posoperatorias para determinar y comparar el resultado en ambos grupos. También se comparó el grado de satisfacción con el procedimiento y el índice de masa corporal y su posible relación con los resultados.
Resultados: Se obtuvieron mejores resultados en los reemplazos totales de cadera asistidos por navegación, con diferencias estadísticamente significativas tanto en la obtención del eje mecánico posoperatorio como en el grado de satisfacción con el procedimiento.
Conclusión: Los reemplazos totales de rodilla primarios guiados por un sistema de navegación fueron más precisos para lograr la alineación final del miembro en un eje mecánico de 0°± 3°.
Análisis clínico y radiográfico del vástago de cadera no cementado “CEMENTFREE”® de fabricación nacional. Resultados a corto plazo
Authors: Vega Carlos Alberto , Sued Matías , Moruno Cossio Favio , Balderrama Uriona Gustavo , Vergara Fernanda , Garavano Esteban , Jimenez Rios Wilmer , Mazzeneth Contreras Alnner 
Published: June 2022

Introducción: La estabilidad del componente femoral y su resistencia al hundimiento son factores críticos para lograr una correcta osteointegración y el éxito clínico de la artroplastia total de cadera no cementada. Hay pocos estudios que evalúen los resultados con vástagos de fabricación nacional, aun los de corto y mediano plazo. El objetivo de este estudio fue realizar un análisis clínico y radiográfico de pacientes sometidos a un reemplazo total de cadera con implante de un componente femoral de fabricación nacional (CEMENTFREE®).
Materiales y Métodos: Se llevó a cabo un estudio retrospectivo con pacientes sometidos a un reemplazo total de cadera con vástago CEMENTFREE®, entre enero de 2015 y agosto de 2020, a cargo del mismo cirujano y en la misma institución.
Resultados: Se implantaron 46 vástagos sin cementación en 42 pacientes (rango etario: 60-81 años). El seguimiento promedio fue de 3 años (mín. 1 año, máx. 5 años). Aplicando el Harris Hip Score se observó una franca mejoría (promedio 47 en el preoperatorio y 93 después de la cirugía). La tasa de supervivencia fue del 100% a los 5 años.
Conclusión: La artroplastia de cadera con el vástago CEMENTFREE® de fabricación nacional ha demostrado ser una opción comparable con otros vástagos importados, en cuanto a los resultados clínicos y radiográficos a corto plazo. Resta evaluar los resultados a mediano y largo plazo.
HAİNLİK VE KAHRAMANLIK GÖLGESİNDE YAKIN DÖNEM TÜRKİSTAN TARİHİNDE BİR FENOMEN:MOLLA İBARAHİM BEG (LAKAY)
Authors: HATUNOĞLU Nurettin 
Published: June 2022

Türkistan coğrafyasının yakın döneminde yaşanan tarihi olaylar işgal ile sonuçlandığı için, o dönemde Sovyet işgaline karşı koyan şahsiyetler hainlik suçlaması ile yaftalanmışlardır. Sovyetler Birliği’nin dağılması sonrası bağımsızlığına kavuşan Türk Cumhuriyetleri’nde yeni bir anlayış ortaya çıktığı için o dönem tarihi olayları farklı bakış açıları ile ele alınmaya başlanmıştır. Bu durum doğal olarak bazı isimler hakkında tartışmaların ortaya çıkmasına sebep olmuştur. Bu bağlamda en tartışmalı isimlerden biri Molla İbrahim Beg olmuştur. Enver Paşa’ya takındığı tavır ve Âlim Han ile kurduğu ilişki yüzünden Sovyet karşıtı çevreler tarafından da eleştirilen Molla İbrahim Beg, kimlik inşa etme sürecinin yaşandığı günümüz Özbekistan’ında tarihi bir kahraman olarak değerlendirilmeye başlanmıştır. Hainlik ve kahramanlık gibi göreceli kavramların gölgesinde kalan Molla İbrahim Beg’in dönemin şartlarına göre değerlendirilmesi ve yaptığı faaliyetlerin ortaya konması çalışmanın ana konusunu teşkil etmektedir.
Çalışmanın giriş kısmında Molla İbrahim Beg’in faaliyet gösterdiği zaman ve mekânda meydana gelen tarihi olayların genel bir özeti yapıldıktan sonra, hainliği ve kahramanlığı ile ilgili farklı görüşlere yer vermek suretiyle konunun ayrıntılarına geçilmiştir. Hainlikle suçlanmasında baş nedenlerden olan Enver Paşa’ya tavrı ve Âlim Han ile olan ilişkisi üzerinde durularak konu daha da derinleştirilmeye ve farklı bakış açıları ortaya konmaya çalışılmıştır. Sovyet karşıtı askeri faaliyetleri ve Afganistan hükümeti ile ilişkileri irdelenerek Türkistan Türklüğü için ön plana çıkışının tarihsel sebepleri ve önemi ortaya konmaya çalışılmıştır. Çalışmanın sonuç kısmında hainlik ve kahramanlık gibi göreceli kavramlardan bağımsız, akademik metoda uygun objektif çıkarımlar yapılmaya çalışılmıştır.
ESKİ KÖYE YENİ ADET: YOUTUBE ÜZERİNDE İŞÇİ SENDİKALARI
Authors: SEÇER Barış , DENİZLİ Umut 
Published: June 2022

Toplum yaşamında eğitim, pazarlama gibi çeşitli alanlarda sosyal medya uygulamaları giderek daha fazla kullanılmaktadır. İşçi sendikaları da üyeleri ile iletişim kurmak ve kamuoyuna duyurular yapmak için sosyal medyayı kullanmaktadır. İşçi sendikalarının üye kaybı nedeniyle sendikal kriz içinde oldukları belirtilmektedir. Bu nedenle sendikaların hem eski üyelerini yeniden kazanmaları hem de üye olmaya sıcak bakmayan kesimlerden yeni üyelere ulaşmaları gerektiği belirtilmektedir. İşçi sendikalarının bu amaçla sosyal medyayı kullanmalarının yararlı olacağı ileri sürülmektedir.
Araştırma kapsamında öncelikle ülkemizdeki 3 konfederasyona bağlı işçi sendikalarının YouTube kanalları incelenmiştir. Daha sonra Petrol İş sendikasının YouTube kanalındaki videolar konuları ve zaman boyutunda analiz edilmiştir. YouTube kanalındaki videoların kamuoyunu bilgilendirme, kamuoyu oluşturma, destek, haklar, faaliyetlerin tanıtımı, grev, kutlama, konuşma, kadınlara yönelik şiddetle mücadele, örgütlenme, tanıtım ve protesto konuları şeklinde sınıflandırılmıştır. Kanaldaki videoların büyük ölçüde mevcut üyelere yönelik olduğu belirlenmiştir. Videoların zaman içerisinde çeşitlendiği görülmektedir.