bluuebunny/crossref_metadata_2025_split huggingface dataset:
An institutional analysis of gender (in)equalities, COVID-19 and governance of elite women's football in Australia, England and the USA
Authors: Clarkson Beth G. , Parry Keith D. , Culvin Alex , Pope Stacey 
Published: February 2022

PurposeWomen's football faces an existential threat from COVID-19. Using case studies, the authors explore the COVID-19 responses of three highly ranked national football associations (Australia, England and the USA) and their professional women's football leagues to (a) compare and shed new insights into the wide range of phased responses and (b) establish recommendations for other nations to navigate major crises with their social and ethical responsibilities to women's football.Design/methodology/approachDrawing on institutional theory, a framework analysis was undertaken examining 71 articles to analyse the gendered global impacts of COVID-19 on women's football.FindingsResults highlight several important recommendations for nations to consider during the pandemic: (1) maintain active communication with the community to allay worries about the future of women's football, (2) gather support from health and government officials, (3) seek out commercial and broadcasting partnerships to drive revenue, and (4) the interests of women's football are best served when responsibility for the elite women's league does not rest (solely) with national football associations.Social implicationsThe authors argue that sport is an interwoven part of society and cannot be separated from gender equality issues irrespective of the pandemic.Originality/valueThe study is first to explore institutional pressures and football governing bodies during COVID-19 and provides a framework for nations to manage major crises.
Precipitation of greigite and pyrite induced by Thermococcales: an advantage to live in Fe‐ and S‐rich environments?
Authors: Gorlas A. , Mariotte T. , Morey L. , Truong C. , Bernard S. , Guigner J.‐M. , Oberto J. , Baudin F. , Landrot G. , Baya C. , Le Pape P. , Morin G. , Forterre P. , Guyot F. 
Published: February 2022

SummaryThermococcales, a major order of archaea inhabiting the iron‐ and sulfur‐rich anaerobic parts of hydrothermal deep‐sea vents, have been shown to rapidly produce abundant quantities of pyrite FeS2 in iron–sulfur‐rich fluids at 85°C, suggesting that they may contribute to the formation of ‘low temperature’ FeS2 in their ecosystem. We show that this process operates in Thermococcus kodakarensis only when zero‐valent sulfur is directly available as intracellular sulfur vesicles. Whether in the presence or absence of zero‐valent sulfur, significant amounts of Fe3S4 greigite nanocrystals are formed extracellularly. We also show that mineralization of iron sulfides induces massive cell mortality but that concomitantly with the formation of greigite and/or pyrite, a new generation of cells can grow. This phenomenon is observed for Fe concentrations of 5 mM but not higher suggesting that above a threshold in the iron pulse all cells are lysed. We hypothesize that iron sulfides precipitation on former cell materials might induce the release of nutrients in the mineralization medium further used by a fraction of surviving non‐mineralized cells allowing production of new alive cells. This suggests that biologically induced mineralization of iron‐sulfides could be part of a survival strategy employed by Thermococcales to cope with mineralizing high‐temperature hydrothermal environments.
Global diversity and distribution of mushroom‐inhabiting bacteria
Authors: Gohar Daniyal , Põldmaa Kadri , Tedersoo Leho , Aslani Farzad , Furneaux Brendan , Henkel Terry W. , Saar Irja , Smith Matthew E. , Bahram Mohammad 
Published: February 2022

SummaryMushroom‐forming fungi are important sources of food and medicine in many regions of the world, and their development and health are known to depend on various microbes. Recent studies have examined the structure of mushroom‐inhabiting bacterial (MIB) communities and their association with local environmental variables, but global‐scale diversity and determinants of these communities remain poorly understood. Here we examined the MIB global diversity and community composition in relation to climate, soil and host factors. We found a core global mushroom microbiome, accounting for 30% of sequence reads, while comprising a few bacterial genera such as Halomonas, Serratia, Bacillus, Cutibacterium, Bradyrhizobium and Burkholderia. Our analysis further revealed an important role of host phylogeny in shaping the communities of MIB, whereas the effects of climate and soil factors remained negligible. The results suggest that the communities of MIB and free‐living bacteria are structured by contrasting community assembly processes and that fungal–bacterial interactions are an important determinant of MIB community structure.
What influences the implementation of IFRS for SMEs? The Brazilian case
Authors: Gonçalves Flauzeliton José Aparecido , De Moura André Aroldo Freitas , Motoki Fabio Yoshio Suguri 
Published: February 2022

AbstractWe investigate factors influencing the implementation of IFRS for SMEs in Brazil. Accountants and accounting firms from all over the country received a questionnaire about the perceptions of IFRS for SMEs. A logit regression on the factors associated with non‐implementation using 426 valid observations suggests that inconsistencies and incomprehensibility issues are the main factors preventing implementation. However, further investigation indicates that once participants know the standard, ‘implementation myths’ are mitigated. Therefore, regulators should increase the availability of education programs, so accountants feel more secure and boost the standard’s implementation. We complement the findings of IASB’s Second Comprehensive Review of the standard.
Coronary circulatory function with increasing obesity: A complex U‐turn
Authors: Upadhyaya Anand , Bhandiwad Anita , Lang Jordan , Sadhu Justin S. , Barrs Chadwick , Jain Sudhir , Brown David L. , Peterson Linda R. , Dehdashti Farrokh , Gropler Robert J. , Schindler Thomas Hellmuth 
Published: February 2022

AbstractAimsThe aim of this investigation was to explore and characterize alterations in coronary circulatory function in function of increasing body weight with medically controlled cardiovascular risk factors and, thus, “metabolically” unhealthy obesity.Materials and MethodsWe prospectively enrolled 106 patients with suspected CAD but with normal stress‐rest myocardial perfusion on 13N‐ammonia PET/CT and with medically controlled or no cardiovascular risk factors. 13N‐ammonia PET/CT concurrently determined myocardial blood flow (MBF) during pharmacologically induced hyperaemia and at rest. Based on body mass index (BMI), patients were grouped into normal weight (BMI: 20.0–24.9 kg/m2, n = 22), overweight (BMI: 25.0–29.9 kg/m2, n = 27), obese (BMI: 30.0–39.9 kg/m2, n = 31), and morbidly obese (BMI ≥ 40kg/m2, n = 26).ResultsResting MBF was comparable among groups (1.09 ± 0.18 vs. 1.00 ± 0.15 vs. 0.96 ± 0.18 vs.. 1.06 ± 0.31 ml/g/min; p = .279 by ANOVA). Compared to normal weight individuals, the hyperaemic MBF progressively decreased in in overweight and obese groups, respectively (2.54 ± 0.48 vs. 2.02 ± 0.27 and 1.75 ± 0.39 ml/g/min; p < .0001), while it increased again in the group of morbidly obese individuals comparable to normal weight (2.44 ± 0.41 vs. 2.54 ± 0.48 ml/g/min, p = .192). The BMI of the study population correlated with the hyperaemic MBF in a quadratic or U‐turn fashion (r = .34, SEE = 0.46; p ≤ .002).ConclusionsThe U‐turn of hyperaemic MBF from obesity to morbid obesity is likely to reflect contrasting effects of abdominal versus subcutaneous adipose tissue on coronary circulatory function indicative of two different disease entities, but needing further investigations.
Technology‐enabled collaborative care for youth with early psychosis: Results of a feasibility study to improve physical health behaviours
Authors: Melamed Osnat , Voineskos Aristotle , Vojtila Lenka , Ashfaq Iqra , Veldhuizen Scott , Dragonetti Rosa , Carriere Rebecca , LaChance Laura , Kohut Sara Ahola , Tulloch Trisha , Argarwal Sri Mahavir , Hahn Margaret , Mulsant Benoit H. , Selby Peter 
Published: February 2022

AbstractAimPsychotic disorders are associated with excess morbidity and premature mortality. Contributing factors include tobacco smoking, low physical activity, and poor nutrition. This study tested a Technology‐Enabled Collaborative Care model to improve health behaviours among youth with early psychosis.MethodsA feasibility study among youth (ages 16–29) with early psychosis in Ontario, Canada. Participants were randomized to either a health coach supervised by a virtual care team (high intensity, n = 29), or self‐directed learning (low intensity, n = 23) for 12 weeks. The primary outcome was participant engagement, defined as self‐perceived benefit of changing health behaviours. Secondary outcomes were measures of health behaviours and programme‐use metrics.ResultsEngagement was higher for high intensity participants for physical activity (adjusted group difference in change at 24 weeks = 3.4, CI95% = 1.9–4.9, p < .001) and nutrition (adjusted difference = 2.9, CI95% = 1.2–4.6, p = .001). No change was observed in health behaviours. Sixty two percent of participants completed 6 or more of the 12 weekly remote individualized health coaching sessions. Nine (39%) low intensity and 12 (41%) high intensity participants completed the final follow‐up.ConclusionsPersonalized health coaching for youth with psychosis is feasible and may have sustained benefits. However, retention with this population for 12 weeks is challenging.
Harvesting can stabilise population fluctuations and buffer the impacts of extreme climatic events
Authors: Peeters Bart , Grøtan Vidar , Gamelon Marlène , Veiberg Vebjørn , Lee Aline M. , Fryxell John M. , Albon Steve D. , Sæther Bernt‐Erik , Engen Steinar , Loe Leif Egil , Hansen Brage Bremset 
Published: February 2022

AbstractHarvesting can magnify the destabilising effects of environmental perturbations on population dynamics and, thereby, increase extinction risk. However, population‐dynamic theory predicts that impacts of harvesting depend on the type and strength of density‐dependent regulation. Here, we used logistic population growth models and an empirical reindeer case study to show that low to moderate harvesting can actually buffer populations against environmental perturbations. This occurs because of density‐dependent environmental stochasticity, where negative environmental impacts on vital rates are amplified at high population density due to intra‐specific resource competition. Simulations from our population models show that even low levels of harvesting may prevent overabundance, thereby dampening population fluctuations and reducing the risk of population collapse and quasi‐extinction following environmental perturbations. Thus, depending on the species' life history and the strength of density‐dependent environmental drivers, low to moderate harvesting can improve population resistance to increased climate variability and extreme weather expected under global warming.
Therapeutic potential of adipose tissue‐derivatives in modern dermatology
Authors: Bellei Barbara , Migliano Emilia , Picardo Mauro 
Published: February 2022

AbstractStem cell‐mediated therapies in combination with biomaterial and growth factor‐based approaches in regenerative medicine are rapidly evolving with increasing application beyond the dermatologic field. Adipose‐derived stem cells (ADSCs) are the more frequently used adult stem cells due to their abundance and easy access. In the case of volumetric defects, adipose tissue can take the shape of defects, restoring the volume and enhancing the regeneration of receiving tissue. When regenerative purposes prevail on volume restoration, the stromal vascular fraction (SVF) rich in staminal cells, purified mesenchymal stem cells (MSCs) or their cell‐free derivatives grafting are favoured. The therapeutic efficacy of acellular approaches is explained by the fact that a significant part of the natural propensity of stem cells to repair damaged tissue is ascribable to their secretory activity that combines mitogenic factors, cytokines, chemokines and extracellular matrix components. Therefore, the secretome's ability to modulate multiple targets simultaneously demonstrated preclinical and clinical efficacy in reversing pathological mechanisms of complex conditions such atopic dermatitis (AD), vitiligo, psoriasis, acne and Lichen sclerosus (LS), non‐resolving wounds and alopecia.This review analysing both in vivo and in vitro models gives an overview of the clinical relevance of adipose tissue‐derivatives such as autologous fat graft, stromal vascular fraction, purified stem cells and secretome for skin disorders application. Finally, we highlighted the major disease‐specific limitations and the future perspective in this field.
T peripheral helper cells in autoimmune diseases*
Authors: Marks Kathryne E , Rao Deepak A 
Published: February 2022

AbstractPathologic T cell–B cell interactions underlie many autoimmune diseases. The T cells that help B cells in autoimmune diseases vary in phenotype and include T cells that lack typical features of T follicular helper cells, such as expression of CXCR5 and BCL6. A population of PD‐1hi CXCR5‐ T peripheral helper (Tph) cells has now been recognized in multiple autoantibody‐associated diseases. Tph cells display a distinctive set of features, merging the ability to provide B cell help with the capacity to migrate to inflamed peripheral tissues. Here, we review the scope of immune‐related conditions in which Tph cells have been implicated and provide a perspective on their potential contributions to pathologic B cell activation in autoimmune diseases. We discuss Tph cells as a promising therapeutic strategy in autoimmunity and consider the utility of tracking Tph cells in blood as a biomarker to quantify aberrant T cell–B cell activation in patients with autoimmune diseases.
Why Migration Justice Still Requires Open Borders
Authors: Sager Alex 
Published: February 2022

ABSTRACTI revisit themes from Against Borders: Why the World Needs Free Movement of People (2020) in dialogue with Gillian Brock's Justice of People on the Move (2020) and Sarah Song's Immigration and Democracy (2019). We share the conviction that current border regimes are deeply unjust but differ in what migration justice requires. Brock and Song continue to give states significant discretion to exclude people from entering and settling in their territories, whereas I contend that migration justice demands open borders. I reject the claim that state self‐determination justifies migration restrictions. Central arguments for open borders highlight the role that restrictive border controls and the state category of ‘immigrant’ play in upholding racialised hierarchies and exploitative economic relations, as well as in inflicting violence against mobile people.
Migration, Open Borders, Human Rights, and Democracy
Authors: Brock Gillian 
Published: February 2022

ABSTRACTTwo important recent books on migration and justice argue for different approaches to how we should view borders. Alex Sager defends open borders, while Sarah Song argues for the rights of democratic communities to find their own balance between open and closed borders. While both authors present significant considerations in defence of their views, in this article I argue that a human‐rights‐oriented account of migration justice captures their strengths well while not sharing the weaknesses I identify with each. In addition, the approach I favour offers some progressive pathways for holding each other to account in reducing migration injustice in our actual world, in ways that are both feasible and normatively compelling.
Supplementation of broiler chicken diets with bovine lactoferrin improves growth performance, histological parameters of jejunum and immune‐related gene expression
Authors: Olyayee Majid , Javanmard Arash , Janmohammadi Hossein , Kianfar Ruhollah , Alijani Sadegh , Mir Ghelenj Seyed Ali 
Published: February 2022

AbstractThe aim of this study was to investigate the influence of dietary supplementation of bovine lactoferrin (bLF) on growth performance, carcass traits, histomorphology of jejunum, immune function and hepatic and splenic gene expression of interferon‐gamma (IFN‐γ) and interleukine‐2 (IL‐2) in broiler chickens. A total of 240 one‐day‐old Ross 308 male broiler chickens were randomly allotted into six dietary treatments with four replicate pens (10 chicks per pen) and fed experimental diet in 3 feeding phases (starter: d 0–10, grower: d 11–24 and finisher: d 25–42). The experimental treatments were (1) corn–soya bean meal‐based basal diet (control), (2–5) basal diet supplemented with 200, 400, 600, 800 mg/kg bLF, respectively, and (6) basal diet supplemented with 200 mg/kg oxytetracycline (OTC). The average body weight gain (ABWG) of broilers fed 800 mg/kg bLF was 8.48% higher than those fed a corn–soybean meal‐based diet during the starter period (d 0–10) (linear effect, p = 0.002; quadratic effect, p = 0.24). Average daily feed intake (ADFI) and the feed conversion ratio (FCR) were not affected (p>0.05) by bLF supplementation. At 42 days of age, the breast meat percentage and carcass yield of broilers fed 800 mg/kg bLF compared with the control group significantly increased by 9.51% and 6.03% respectively (p < 0.05). Compared with the chicks fed the control diet, the chicks fed diets supplemented with bLF had higher villus height, muscle thickness and villus surface area (p > 0.05). Dietary bLF inclusion increased the total immunoglobulin (IgT) titre against sheep red blood cells (SRBCs) antigen (linear effect, p = 0.031; quadratic effect, p = 0.035) and improved the phytohaemagglutinin‐P (PHA‐P)‐skin test of broilers. Compared with the control, bLF enhanced the gene expression of IFN‐γ in spleen (p = 0.048, linear effect, p = 0.009; quadratic effect, p = 0.093) and liver (p = 0.012, linear effect, p = 0.008; quadratic effect, p = 0.01) and IL‐2 expression in spleen (p = 0.021, linear effect, p = 0.026; quadratic effect, p = 0.103). The bLF supplementation had no effect on IL‐2 gene expression in liver (p > 0.05, linear effect, p = 0.213; quadratic effect, p = 0.159). In conclusion, we found that supplementation of broiler diets with 800 mg/kg bLF can improve the growth performance, carcass yield, cell‐mediated and antibody‐mediated immune responses and enhance the IL‐2 and IFN‐γ gene expression of broilers.
Social Sin and the Sinless Savior: Delineating Supra‐Personal Sin in Continuity with Conciliar Christology
Authors: Hill Daniel Lee , Kieser Ty 
Published: February 2022

AbstractThis article addresses the seeming incongruity between supra‐personal accounts of sin and conciliar Christology. Supra‐personal accounts of sin, in their variegated forms, propose that sin is not merely reducible to the human will, but is enmeshed within the societal or social structures that all human beings inhabit. Such accounts become potentially problematic when considered in conjunction with the Christology of the ecumenical councils—especially the affirmation of Christ’s sinlessness. Specifically, if sin is not localized to the individual person and their will, how can we affirm that Christ genuinely participates in a warped society and sinful social structures while remaining sinless? This article articulates the fundamentals of social accounts of sin, defends the requisite sinlessness of Christ from the councils, and establishes guiding principles for properly navigating the relationship between Christology and structural sin. Ultimately it argues that an affirmation of Christ’s sinlessness ought to orient and delineate a Christian understanding of supra‐personal sin.
Azole resistance in Aspergillus fumigatus. The first 2‐year's Data from the Danish National Surveillance Study, 2018–2020
Authors: Risum Malene , Hare Rasmus Krøger , Gertsen Jan Berg , Kristensen Lise , Rosenvinge Flemming Schønning , Sulim Sofia , Abou‐Chakra Nissrine , Bangsborg Jette , Røder Bent Løwe , Marmolin Ea Sofie , Astvad Karen Marie Thyssen , Pedersen Michael , Dzajic Esad , Andersen Steen Lomborg , Arendrup Maiken Cavling 
Published: February 2022

AbstractBackgroundAzole resistance complicates treatment of patients with invasive aspergillosis with an increased mortality. Azole resistance in Aspergillus fumigatus is a growing problem and associated with human and environmental azole use. Denmark has a considerable and highly efficient agricultural sector. Following reports on environmental azole resistance in A. fumigatus from Danish patients, the ministry of health requested a prospective national surveillance of azole‐resistant A. fumigatus and particularly that of environmental origin.ObjectivesTo present the data from the first 2 years of the surveillance programme.MethodsUnique isolates regarded as clinically relevant and any A. fumigatus isolated on a preferred weekday (background samples) were included. EUCAST susceptibility testing was performed and azole‐resistant isolates underwent cyp51A gene sequencing.ResultsThe azole resistance prevalence was 6.1% (66/1083) at patient level. The TR34/L98H prevalence was 3.6% (39/1083) and included the variants TR34/L98H, TR343/L98H and TR34/L98H/S297T/F495I. Resistance caused by other Cyp51A variants accounted for 1.3% (14/1083) and included G54R, P216S, F219L, G54W, M220I, M220K, M220R, G432S, G448S and Y121F alterations. Non‐Cyp51A‐mediated resistance accounted for 1.2% (13/1083). Proportionally, TR34/L98H, other Cyp51A variants and non‐Cyp51A‐mediated resistance accounted for 59.1% (39/66), 21.2% (14/66) and 19.7% (13/66), respectively, of all resistance. Azole resistance was detected in all five regions in Denmark, and TR34/L98H specifically, in four of five regions during the surveillance period.ConclusionThe azole resistance prevalence does not lead to a change in the initial treatment of aspergillosis at this point, but causes concern and leads to therapeutic challenges in the affected patients.
Wavelength‐dependent DNA Photodamage in a 3‐D human Skin Model over the Far‐UVC and Germicidal UVC Wavelength Ranges from 215 to 255 nm
Authors: Welch David , Aquino de Muro Marilena , Buonanno Manuela , Brenner David J. 
Published: February 2022

ABSTRACTThe effectiveness of UVC to reduce airborne‐mediated disease transmission is well established. However, conventional germicidal UVC (~254 nm) cannot be used directly in occupied spaces because of the potential for damage to the skin and eye. A recently studied alternative with the potential to be used directly in occupied spaces is far UVC (200–235 nm, typically 222 nm), as it cannot penetrate to the key living cells in the epidermis. Optimal far‐UVC use is hampered by limited knowledge of the precise wavelength dependence of UVC‐induced DNA damage, and thus we have used a monochromatic UVC exposure system to assess wavelength‐dependent DNA damage in a realistic 3‐D human skin model. We exposed a 3‐D human skin model to mono‐wavelength UVC exposures of 100 mJ/cm2, at UVC wavelengths from 215 to 255 nm (5 nm steps). At each wavelength, we measured yields of DNA‐damaged keratinocytes, and their distribution within the layers of the epidermis. No increase in DNA damage was observed in the epidermis at wavelengths from 215 to 235 nm, but at higher wavelengths (240–255 nm) significant levels of DNA damage was observed. These results support use of far‐UVC radiation to safely reduce the risk of airborne disease transmission in occupied locations.