bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioequivalence and Pharmacokinetic Profiles of 2 Trimetazidine Modified‐release Tablets Under Fasting and Fed Conditions in Chinese Healthy Subjects
Authors: Wang Jue , Yang Yuanying , Huang Xiaomei , Huang Jian , Zhang Bikui 
Published: December 2022

AbstractThis study aims to assess the bioequivalence of test and reference formulations of trimetazidine dihydrochloride in healthy Chinese volunteers under fasting and fed conditions, and to determine the effect of food on the pharmacokinetic profiles of both formulations. A randomized, open‐label, crossover, four‐period study with a 7‐day washout period was conducted in 24 healthy Chinese subjects. The subjects fasted for at least 10 hours before being given a single 35‐mg dose of the test and reference tablets. Venous blood samples were taken from predose at 0 hours to postdose at 36 hours at scheduled time points. The main pharmacokinetic parameters were calculated with a noncompartmental model. The nonparametric test of Tmax under both conditions showed no significant difference between the two formulations (P > .05). The 90% confidence intervals of geometric mean ratio of lnCmax and lnAUC0→∞ (the logarithmic values of area under the plasma concentration‐time curve [AUC] and mean maximum plasma concentration [Cmax]) all fell within 80%–125%. Cmax in the fed state was slightly higher than that in the fasting state (P < .05), while other pharmacokinetic parameters were comparable. No severe adverse events occurred. The test and reference formulations were bioequivalent under both fasting and fed conditions. Food did not affect the pharmacokinetic profiles of trimetazidine in Chinese healthy volunteers, therefore trimetazidine is suitable for administration under fasting or fed conditions.
Evaluating differences in setting expected body weight for children and adolescents in eating disorder treatment
Authors: Steinberg Dori M. , Perry Taylor R. , Freestone David , Hellner Megan , Baker Jessica H. , Bohon Cara 
Published: December 2022

AbstractObjectiveWeight restoration or weight gain is a common goal in eating disorder treatment. However, approaches to determine expected body weight (EBW) vary. A standardized approach based on normative data for a patient's age and gender uses weight associated with median BMI (mBMI). An individualized approach predicts EBW based on a patient's individual growth trajectory. Little research has examined differences in these approaches.MethodWeight and clinical data were collected from patients ages 6–20 enrolled in virtual eating disorder treatment. EBW associated with mBMI was compared with EBW using the individualized approach. Linear mixed effects models examined differences in weight, eating disorder symptoms, depression, and anxiety, and whether EBW approach varied by patient characteristics.ResultsPatients (N = 609) were on average age 15.6 (2.29), 85% were cisgender female, and predominantly diagnosed with anorexia nervosa (83.1%). The individualized approach led to significantly higher EBW on average (mean difference = 8.4 lbs [SE: .75]; p < .001) compared to mBMI; 70% of patients had a higher EBW using the individualized approach. Notably, EBW varied based on gender and diagnosis and it took longer on average to achieve individualized EBW. Time was the strongest predictor of changes in psychosocial outcomes and there were no significant differences by EBW approach.DiscussionResults from this study indicate that an individualized approach led to significantly higher EBWs compared with using mBMI. As underestimation of EBW may lead to higher risk of relapse, eating disorder professionals should consider using an individualized approach for setting EBW.Public SignificanceFor eating disorder patients who need to gain weight, accurately estimating target body weight for eating disorder treatment is critical to recovery and preventing relapse. An individualized, patient‐centered approach to estimating target body weight more accurately estimated target body weight than the standardized, median body mass index approach. Using an individualized approach to treatment may improve a patient's likelihood of full recovery.
Four Polyoxometalate‐Viologen Discoloration Materials for UV Probing, Inkless and Erasable Printing and Visual Detection of Hg2+
Authors: Lu Qinghai , Tian Aixiang , Yu Shuang , Xu Xi , Ma Shufang , Yang Mengle 
Published: December 2022

AbstractIn this work, four POM‐based compounds containing viologen ligands were synthesized, namely {CuII(tybipy)2(DMF)2[H2(β‐Mo8O26)]2} ⋅ 4 C2H7N (1), (Htybipy)2 ⋅ (β‐Mo8O26) (2) (tybipy⋅Br=1‐Thiophen‐3‐ylmethyl‐[4,4’]bipyridinyl‐1‐ium bromide), [CuII(nibipy)2(4,4’‐bipy)] ⋅ (SiW12O40) (3), (Hnibipy)2 ⋅ (δ‐Mo8O26) (4) (nibipy⋅Cl=1‐(4‐Nitro‐benzyl)‐[4,4’]bipyridinyl‐1‐ium chloride, 4,4’‐bipy=4,4’‐bipyridine). In compounds 1 and 3, Cu2+ and mixed organic ligands modify POM anions. On the other hand, 2 and 4 are supramolecular structures only containing ligands and anions. Under Xe lamp with filter (300‐400 nm) irradiation, these four compounds showed good photoresponse and photochromic ability, which can be used in mixed matrix films for visible UV detectors. Compounds 1–4 also have photoluminescence property and show good fluorescence quenching effect. A suspension of four compounds can be evenly spread on filter paper as inkless and erasable printing materials. Compounds 1 and 2 were also used as Hg2+ fluorescence detectors. The fluorescence intensity of 1 decreased by ca. 90 % when the concentration of Hg2+ increased to 40 mM. Moreover, we also prepared composites 1/2@Hg2+,1@Cu2+, 1@Co2+ by introducing 1/2 and Hg2+, Cu2+ and Co2+ to detection paper respectively, which can act as photochromic materials with features of fast color recovery.
Adaptive secure transmission for two‐way energy harvesting relay networks with two‐sided eavesdropping
Authors: Song Xin , Zhu Jiahui , Zhang Runfeng , Peng Mingjv , Xu Siyang 
Published: December 2022

AbstractIn this paper, for energy harvesting (EH) two‐way relay (TWR) networks with two‐sided eavesdroppers, the problem of secure information transmission is investigated. Based on this system model, a novel full‐duplex (FD) relaying jamming scheme is proposed to achieve simultaneously information reception, EH and jamming signal transmission at the cooperative relay. Particularly, the entire transmission phase and received signal at relay node are divided into two different time durations and three different parts by time allocation (TA) and power splitting (PS), respectively. For the aim of maximizing the sum secrecy rate, adaptive TA factor and PS factor are jointly optimized. We derive the non‐convex optimization function. To solve this highly non‐convex optimization problem, a heuristic approach based on particle swarm optimization (PSO) is proposed. Numerical results verify the superior sum secrecy rate of the proposed scheme. Besides, the impact of system parameters on the output performance is analyzed.
Membrane lipid metabolism is involved in regulating γ‐aminobutyric acid‐mediated cold tolerance in peach fruit
Authors: Song Chunbo , Yang Zhenfeng , Xiao Xiang 
Published: December 2022

AbstractThe cold‐sensitive peach fruits are prone to chilling injury (CI). γ‐aminobutyric acid (GABA) has been confirmed to effectively improve peaches’ cold tolerance. This research aimed to probe the role of dynamic changes in membrane lipid metabolism in GABA‐mediated peaches’ cold tolerance and reveal the underlying mechanisms based on lipid metabolomics. GABA treatment improved peaches’ cold tolerance by reducing phosphatidic acid (PA) accumulation via inhibiting phospholipid degradation, attenuating PA biosynthesis, and maintaining higher phosphatidylcholine (PC) and phosphatidylethanolamine (PE) levels. Under chilling conditions, GABA treatment protected peaches against low‐temperature stress and delayed CI by maintaining higher PC and PE levels and enhancing the massive accumulation of diacylglycerol (DAG) and triacylglycerol (TAG). This study provides a novel mechanism regulating cold tolerance of postharvest peach fruits.
Hyaluronic acid treatment versus standard of care in chronic wounds in a German setting: Cost‐effectiveness analysis
Authors: Blunck Dominik , Schöffski Oliver 
Published: December 2022

AbstractBackground and AimsChronic wounds are a major burden for worldwide health care systems. In the management of chronic wounds several strategies with innovative and active agents emerged in the past few years, such as hyaluronic acid containing wound dressings. Evidence comparing the cost‐effectiveness of hyaluronan and standard of care dressings (hydrofiber with silver) is still missing. The aim of the study is thus, to assess the cost‐effectiveness of hyaluronan versus standard of care dressings (hydrofiber with silver) in chronic wounds from a German statutory health insurance perspective.MethodsA decision tree was modeled to quantify the cost and healing rate at 12 weeks for the hyaluronan and silver dressings strategies. Input parameters were collected literature‐based, accounting for healing rates, dressing prices and prices for dressing changes and associated home care. Parameter uncertainty was accounted for by one‐way and probabilistic sensitivity analysis.ResultsHyaluronic acid showed a better healing rate (60.68%) and noticeable lower cost (749.80 Euro) compared to standard of care (silver containing) dressings (59.62%; 883.05 Euro), resulting in an Incremental Cost Effectiveness Ratio of −12,570.57. The hyaluronan approach is hence a dominant strategy in chronic wound management. Sensitivity analysis confirmed these results, giving a range of 60%– 70% of cost‐effective scenarios.ConclusionsHyaluronic acid dressings showed to be a clinical more effective strategy at significantly lower cost in chronic wounds compared to standard of care (hydrofiber with silver).
Simulation for flow across heated square cylinders
Authors: Patil Ravibala A. , Nandgaonkar Milankumar R. , Sewatkar Chandrashekhar M. 
Published: December 2022

AbstractThe thermal lattice Boltzmann method is used to examine forced convection heat transfer from six inline heated square cylinders forRe = 100 at 0.5 ≤ s/d ≤ 4.0, wheresis the distance between the surfaces of two cylinders anddis the cylinder size. Such a heat transfer is transient in nature for which the present work reports heat transfer regimes such as synchronous, quasiperiodic and chaotic. For 0.5 ≤ s/d ≤ 1.5 the heat transfer is synchronous, for 1.5 ≤ s/d ≤ 3.0 it is quasiperiodic and for 3.0 ≤ s/d ≤ 4.0 it is chaotic in nature atRe = 100. These regimes are confirmed through cylinder Nusselt number signals, its power spectra, and heat wake interference. The appearance of heat transfer regimes for inline heated cylinders is similar to the appearance of flow regimes for inline unheated cylinders except for the fact that transition from synchronous to quasiperiodic regime occurs ats/d = 1.5 for heat transfer and ats/d = 1.1 for flow. The synchronous heat transfer regime is characterized by a single heat wake that envelopes all cylinders while quasiperiodic heat transfer regime is characterized by the formation of thermal blobs in the gap between cylinders. A chaotic heat transfer regime is characterized by the shedding of thermal blobs and interference of thermal blobs by downstream cylinders. Regardless of spacing, the average Nusselt number encountered by cylinders is smaller than that for the isolated cylinder. The novelty of the work is that transitions occurring in the flow of heat are considered for an understanding of heat flow from bluff bodies.
Blood‐based tumor fibrosis markers as diagnostic and prognostic biomarkers in patients with biliary tract cancer
Authors: Christensen Troels D. , Jensen Christina , Larsen Ole , Leerhøy Bonna , Hansen Carsten P. , Madsen Kasper , Høgdall Dan , Karsdal Morten A. , Chen Inna M. , Nielsen Dorte , Johansen Julia S. , Willumsen Nicholas 
Published: December 2022

AbstractBiliary tract cancer (BTC) is characterized by a desmoplastic extracellular matrix (ECM). We tested the diagnostic and prognostic use of seven circulating biomarkers of ECM remodeling: pro‐peptides of type III collagen (PRO‐C3), VI (PRO‐C6) and XI (PRO‐C11), matrix metalloprotease (MMP) degraded type III collagen (C3M) and type IV collagen (C4M) fragments, granzyme B degraded type IV collagen fragments (C4G) and MMP degraded and citrullinated vimentin (VICM) a marker of macrophage activation. The study included 269 patients with all stages of BTC and 49 patients with benign biliary tract diseases. Serum samples from BTC patients were collected before surgery, or before first‐ or second‐line chemotherapy. C3M, C4M, PRO‐C3, PRO‐C6, PRO‐C11 and VICM levels were elevated in patients with BTC compared to patients with benign disease. Receiver operating characteristics curve analyses identified PRO‐C3 (area under curve [AUC] = 0.87) as the ECM marker with the best diagnostic performance. The ECM biomarkers correlated with inflammation biomarkers (C‐reactive protein [CRP], interleukin‐6 [IL‐6] and YKL‐40) but not with CA19‐9. To investigate prognostic performance, patients were split into three cohorts (first‐line, second‐line and surgery). Elevated ECM biomarker levels were associated with short overall survival (OS), but only pretreatment PRO‐C3 and PRO‐C6 were associated with OS in both the first‐line and second‐line settings when adjusting for CA19‐9, performance status and stage in a multivariate Cox‐regression analyses. Our results indicate that collagen remodeling is increased in patients with BTC and associated with survival. The collagen pro‐peptides (PRO‐C3 and PRO‐C6) could be used as novel biomarkers in these patients.
Guide to lower urogenital tract neoplasia in dogs
Authors: Néčová Slavomíra 
Published: December 2022

Background: With the improvement of healthcare in veterinary medicine, pets are living longer. However, this comes with a higher risk of cancer diagnosis, such as lower urogenital tract neoplasia. As veterinary medicine progresses, improved diagnostic techniques and treatment are becoming available and more pets may benefit from cancer treatment.Aim of the article: This article summarises current information about lower urogenital tract neoplasia in dogs, and outlines the clinical signs, staging, differential diagnoses and treatment options that are available within the veterinary practice.
Introducing the Animal Health and Welfare Pathway: role of the farm vet
Authors: Statham Jonathan , Russell James 
Published: December 2022

Background: The sustainable farming incentive (SFI), which is one of the schemes introduced in the Agricultural Transition Plan, aims to address specific environmental issues alongside food production. Part of this will involve making improvements to farming via the Animal Health and Welfare Pathway to drive better standards and efficiency. Vets will be heavily involved in delivering this pathway, particularly through undertaking annual health and welfare reviews on farm.Aim of the article: This article details to practitioners how the Animal Health and Welfare Pathway was developed and what it aims to achieve both in year one and its longer‐term ambitions. It also outlines how vets will play a vital role in the delivery of the pathway, and the benefits that this will bring for the profession, farming industry and wider society.
Clinical value of long non‐coding RNA KCNQ1OT1 in estimating the stenosis, lipid level, inflammation status, and prognostication in coronary heart disease patients
Authors: Zhu Lin , Feng Qiang , Fan Jie , Huang Jing , Zhu Yanling , Wu Yanqiang , Hou Aijun , Huo Yanfei 
Published: December 2022

AbstractObjectiveLong non‐coding RNA KQT‐like subfamily, member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) could regulate lipid metabolism, vascular smooth muscle cell function, inflammation, and atherosclerosis. This study aimed to evaluate whether lncRNA KCNQ1OT1 could serve as a biomarker for reflecting coronary heart disease (CHD) patients' disease situation and prognosis.MethodsLncRNA KCNQ1OT1 expression was determined in peripheral blood mononuclear cells from 267 CHD patients, 50 disease controls (DCs) (unexplained chest pain), and 50 healthy controls (HCs) by the RT‐qPCR method. TNF‐α, IL‐17A, VCAM‐1, and ICAM‐1 were determined by the ELISA procedure in serum from CHD patients only. The mean (95% confidential interval) follow‐up duration was 16.0 (15.3–16.8) months.ResultsLncRNA KCNQ1OT1 was highest in CHD patients, followed by DCs, and lowest in HCs (p < 0.001). LncRNA KCNQ1OT1 could distinguish the CHD patients from DCs (area under the curve [AUC]: 0.757) and from the HCs (AUC: 0.880). LncRNA KCNQ1OT1 was positively associated with triglyceride (p = 0.026), low‐density lipoprotein cholesterol (p = 0.023), cardiac troponin I (p = 0.023), and C‐reactive protein (p = 0.001). Besides, lncRNA KCNQ1OT1 was also positively linked with the Gensini score (p = 0.008). Furthermore, lncRNA KCNQ1OT1 was positively related to the TNF‐α (p < 0.001), IL‐17A (p = 0.008), and VCAM‐1 (p = 0.003). LncRNA KCNQ1OT1 was elevated in CHD patients with MACE compared to those without MACE (p = 0.006); moreover, lncRNA KCNQ1OT1 high was associated with shorter MACE‐free survival (p = 0.018).ConclusionCirculating lncRNA KCNQ1OT1 expression not only reflects the stenosis degree, blood lipid level, and inflammation status but also predicts the MACE risk, while a large‐scale study is needed for verification.
Exploring parental cystic fibrosis disclosure to well children
Authors: Boyer Amanda , Raraigh Karen , Riley Stephanie , Frank Julie 
Published: December 2022

AbstractCystic fibrosis (CF), a genetic disease and chronic illness, affects multiple organ systems and requires exceptional medical care and treatment. Few studies have assessed the diagnosis disclosure process to well children when their sibling(s) have CF, and none have evaluated the association between parental knowledge of CF and the disclosure of CF. The objectives of this study were to assess parental understanding of CF, demonstrate the most commonly shared topics and their frequencies of discussion with well children, and identify associations between parental understanding of CF and aspects of the disclosure process to well children. Parents were recruited from CF support organizations and asked to complete an online, anonymous survey. Individuals were eligible to participate in the study if they had at least one living child with CF and at least one living child without CF. Completed surveys from 48 individuals revealed that most parents began discussing a sibling's diagnosis of CF with the first‐born well child at 5.4 years old. Topics related to CF were discussed openly and as needed with their well children (n = 44). The most frequently discussed topic, and the topic ranked most important (1.93 of 5, SD: 1.17) by 40 participants (90.9%), was medical concerns and treatment for CF. Fewer parents (n = 18, 40.9%) reported discussing the financial impact of CF, and many ranked this as least important to share (4.64 of 5, SD: 0.75). The CF knowledge assessment revealed that participants were well‐informed about CF, with a mean total score of 8.9/10 (SD: 0.91). There were no associations between CF knowledge assessment scores, education level, income, and the topics discussed with well children. These results can be utilized by genetic counselors and other healthcare specialists in discussion with parents about the disclosure process of a diagnosis of CF to well children.
Impact of large amount of intra‐abdominal lavage on surveillance of surgical site infection after hepato‐pancreato‐biliary surgery: A prospective cohort study
Authors: Yasukawa Koya , Umemura Kentaro , Shimizu Akira , Kubota Koji , Notake Tsuyoshi , Hosoda Kiyotaka , Hayashi Hikaru , Soejima Yuji 
Published: December 2022

AbstractBackground/PurposeIn hepatobiliary and pancreatic (HBP) surgery, the role and significance of intra‐abdominal lavage (IAL) for surgical site infection (SSI) is controversial.MethodsThis prospective study was performed between July 2020 and July 2022. A total of 150 patients, 10‐L IAL was performed. The lavage fluid at 1‐L, 5‐L, and 10‐L was subjected to bacterial culture examination. Risk factors for SSI were evaluated.ResultsBacterial positivity rate significantly decreased as follows: 1‐L, 36% (n = 54); 5‐L, 27% (n = 41); 10‐L, 23% (n = 35) (36% vs 23%, p = .001). Patients with positive lavage fluid culture at 10‐L had significantly higher incidence of both incisional (37% vs 6%, p < .01) and organ/space (54% vs 3%, p < .01) SSI. Multivariate analysis revealed positivity for bacterial culture at 10‐L as the strongest independent risk factor for incisional SSI (OR 13.0, 95% CI: 3.86–43.6, p < .01), followed by postoperative pancreatic fistula (OR 11.7, 95% CI: 3.03–45.6, p < .01). Likewise, in organ/space SSI, positivity for bacterial culture at 10‐L was the strongest independent risk factor (OR 48.9, 95% CI:12.1–197.7, p < .01), followed by digestive reconstruction (OR 5.20, 95% CI: 1.45–18.6, p = .01).ConclusionIAL decreased the intraperitoneal contamination rate in a volume‐dependent manner and can be useful in the surveillance of SSI development in HBP surgery.
Clinical feasibility of endoscopic ultrasound‐guided biliary drainage for preoperative management of malignant biliary obstruction (with videos)
Authors: Mukai Shuntaro , Itoi Takao , Tsuchiya Takayoshi , Ishii Kentaro , Tonozuka Ryosuke , Nagakawa Yuichi , Kozono Shingo , Takishita Chie , Osakabe Hiroaki , Sofuni Atsushi 
Published: December 2022

AbstractBackground/PurposeEUS‐guided biliary drainage (EUS‐BD) has recently been reported to be a useful salvage technique after ERCP fail. However, data on EUS‐BD used for preoperative biliary drainage (PBD) are limited. The aim of this study was to verify the clinical feasibility of EUS‐BD for PBD.MethodsPBD was performed for malignant biliary obstruction in 318 patients at our institution between July 2014 and April 2022. Fifteen (4.7%) of these patients underwent surgical resection after preoperative EUS‐BD (HGS 13; HDS 1; AGS with HGS 1) and were retrospectively analyzed.ResultsThe stent was successfully placed in all 15 cases with a median procedure time of 15 min (technical success rate 100%). The median total bilirubin value decreased significantly from 3.7 before drainage to 0.9 after surgery (p < .001) and cholangitis was well managed (clinical success rate 100%). Surgery was performed at a median of 22 days after drainage, and there were no stent‐related adverse events or recurrences of biliary obstruction. Severe surgery‐related adverse events occurred in three cases, but none were associated with EUS‐BD. The stent was removed during surgery in 12 cases.ConclusionsEUS‐BD can be a feasible and safe alternative method of PBD for malignant biliary obstruction after ERCP fail.