bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Integrated Skyhook-Linear Quadratic Regulator Coordinated Control Approach for Semi-Active Vehicle Suspension Systems
Authors: Lu Yukun , Khajepour Amir , Hajiloo Reza , Korayem Amin Habibnejad , Zhang Ruihe 
Published: December 2022

Abstract
Vehicle semi-active suspension systems can provide a satisfactory compromise of ride comfort and handling stability. With the rapid developments of damping control methodologies, ride comfort is expected to be improved in all three directions, i.e., vertical, roll, and pitch. Considering this kind of multi-objective coordinated control problem, Model Predictive Control (MPC) gains lots of attention in the recent decade. However, the MPC algorithm is expensive for real-time implementations due to its computational complexity. This paper introduces an integrated Skyhook and linear quadratic regulator (LQR) control approach, which can be easily processed on an automotive-grade microcontroller because of its concise algorithm. Meanwhile, it has great potential in attenuating vehicle body vibrations in vertical and rotational directions at the same time. Its control performances are evaluated through the co-simulation between carsim and matlab/simulink based on three different road conditions. The Buick Enclave, which is a full-size sport utility vehicle (SUV), is modeled in carsim for evaluating the control performance. The results demonstrated the control efficiency of the integrated Skyhook-LQR approach, which is even better than MPC, especially in vertical and pitch directions.
The Mechanical Characterization and Comparison of Male and Female Calvaria Under Four-Point Bending Impacts
Authors: Adanty Kevin , Bhagavathula Kapil B. , Tronchin Olivia , Li David X. , Rabey Karyne N. , Doschak Michael R. , Adeeb Samer , Hogan James , Ouellet Simon , Plaisted Thomas A. , Satapathy Sikhanda S. , Romanyk Dan L. , Dennison Christopher R. 
Published: December 2022

Abstract
The circumstances in which we mechanically test and critically assess human calvarium tissue would find relevance under conditions encompassing real-world head impacts. These conditions include, among other variables, impact velocities, and strain rates. Compared to quasi-static loading on calvaria, there is less reporting on the impact loading of the calvaria and consequently, there are relatively fewer mechanical properties on calvaria at relevant impact loading rates available in the literature. The purpose of this work was to report on the mechanical response of 23 human calvarium specimens subjected to dynamic four-point bending impacts. Impacts were performed using a custom-built four-point impact apparatus at impact velocities of 0.86–0.89 m/s resulting in surface strain rates of 2–3/s—representative of strain rates observed in vehicle collisions and blunt impacts. The study revealed comparable effective bending moduli (11–15 GPa) to the limited work reported on the impact mechanics of calvaria in the literature, however, fracture bending stress (10–47 MPa) was relatively less. As expected, surface strains at fracture (0.21–0.25%) were less compared to studies that performed quasi-static bending. Moreover, the study revealed no significant differences in mechanical response between male and female calvaria. The findings presented in this work are relevant to many areas including validating surrogate skull fracture models in silico or laboratory during impact and optimizing protective devices used by civilians to reduce the risk of a serious head injury.
Effect of Vertical Jump and Sprint Training on Power and Speed Performance Transfer
Authors: Gheller Rodrigo Ghedini , Kons Rafael Lima , Pupo Juliano Dal , Detanico Daniele 
Published: December 2022

The aim of this systematic review was to investigate the effect of specific sprint and vertical jump training interventions on transfer of speed–power parameters. The data search was carried out in three electronic databases (PubMed, SCOPUS, and SPORTDiscus), and 28 articles were selected (13 on vertical jump training and 15 on sprint training). We followed the PRISMA criteria for the construction of this systematic review and used the Physiotherapy Evidence Database (PEDro) scale to assess the quality of all studies. It included studies with a male population (athletes and nonathletes, n = 512) from 18 to 30 years old who performed a vertical jump or sprint training intervention. The effect size was calculated from the values of means and SDs pre- and posttraining intervention. The percentage changes and transfer of training effect were calculated for vertical jump training and sprint training through measures of vertical jump and sprint performance. The results indicated that both training interventions (vertical jump training and sprint training) induced improvements in vertical jump and linear sprint performance as well as transfer of training to speed–power performance. However, vertical jump training produced greater specific and training transfer effects on linear sprint than sprint training (untrained skill). It was concluded that vertical jump training and sprint training were effective in increasing specific actions of vertical jump and linear sprint performance, respectively; however, vertical jump training was shown to be a superior alternative due to the higher transfer rate.
Palladium Catalysts Based on Nitrogen-Containing Porous Aromatic Frameworks for Hydrogenation of Unsaturated Compounds
Authors: Makeeva D. A. , Kulikov L. A. , Oskina E. D. , Uvarov O. V. , Maximov A. L. , Karakhanov E. A. 
Published: December 2022

Abstract
Amino-containing porous aromatic frameworks, designated as PAF-20–NH2-pre/post and PAF-30–NH2-pre/post, were synthesized using a combination of pre- and post-modification, and were then used to prepare a number of Pd catalysts with various metal concentrations. The activity of the catalysts was tested in selective hydrogenation of a series of alkynes and dienes at 60°C and 10 atm hydrogen pressure. The effects of the modification technique and palladium content on the morphology and catalytic activity of nanoparticles were investigated, and the reaction patterns were identified for each substrate type. The reusability of the catalysts over at least six reaction cycles was demonstrated.
Improving equity in access to early diagnosis of cancer in different healthcare systems of Latin America: protocol for the EquityCancer-LA implementation-effectiveness hybrid study
Authors: Vázquez Maria-Luisa , Vargas Ingrid , Rubio-Valera Maria , Aznar-Lou Ignacio , Eguiguren Pamela , Mogollón-Pérez Amparo-Susana , Torres Ana-Lucía , Peralta Andrés , Dias Sónia , Jervelund Signe Smith 
Published: December 2022

IntroductionHealthcare fragmentation, a main cause for delay in cancer diagnosis and treatment, contributes to high mortality in Latin America (LA), particularly among disadvantaged populations. This research focuses on integrated care interventions, which have been limitedly implemented in the region. The objective is to evaluate the contextual effectiveness of scaling-up an integrated care intervention to improve early diagnosis of frequent cancers in healthcare networks of Chile, Colombia and Ecuador.Methods and analysisThis research is two pronged: (A) quasi-experimental design (controlled before and after) with an intervention and a control healthcare network in each LA country, using an implementation-effectiveness hybrid approach to assess the intervention process, effectiveness and costs; and (B) case study design to analyse access to diagnosis of most frequent cancers. Focusing on the most vulnerable socioeconomic population, it develops in four phases: (1) analysis of delays and barriers to early diagnosis (baseline); (2) intervention adaptation and implementation (primary care training, fast-track referral pathway and patient information); (3) intracountry evaluation of intervention and (4) cross-country analysis. Baseline and evaluation studies adopt mixed-methods qualitative (semistructured individual interviews) and quantitative (patient questionnaire survey) methods. For the latter, a sample size of 174 patients with cancer diagnosis per healthcare network and year was calculated to detect a proportions difference of 15%, before and after intervention (α=0.05; β=0.2) in a two-sided test. A participatory approach will be used to tailor the intervention to each context, led by a local steering committee (professionals, managers, policy makers, patients and researchers).Ethics and disseminationThis study complies with international and national legal stipulations on ethics. It was approved by each country’s ethical committee and informed consent will be obtained from participants. Besides the coproduction of knowledge with key stakeholders, it will be disseminated through strategies such as policy briefs, workshops, e-tools and scientific papers.
Expression of poly(ADP-ribose) polymerase-1 gene and optical coherence tomography angiographic parameters among patients with multiple sclerosis
Authors: Mossa Elshimaa A Mateen , Sayed Khulood Muhammad , Awny Islam , Mohamed Nesma A , Ali Tasneem , Hemdan Shimaa Badawy , Helaly Ahmed A , Abdellatif Mohammed G , Farag Radwa Mohammed , Alsmman Alahmady Hamad , Mounir Amr 
Published: December 2022

Back ground/aimsTo analyse different parameters of the macula, disc and their vascular affection using optical coherence tomography (OCT) and angiography (OCT-A) in patients with multiple sclerosis (MS) correlating these changes to PARP-1 gene expression in blood.MethodsThis cross-sectional study included 80 eyes of the clinically diagnosed relapsing-remitting phenotype of MS. The study included three groups; group (A) included 40 eyes of 20 patients with MS with a history of optic neuritis (MS+ON), group (B) included 40 eyes of 20 patients with MS without a history of ON (MS-ON) and group (C) (the control group) consisted of 40 eyes of 20 matched participants not suffering from any ocular or systemic disease. OCT and OCT-A, RTVue (Optovue, Fermont, California, USA) were done for all eyes for evaluating the macular and disc changes. Qualitative real-time PCR for estimation of PARP1 gene expression level was performed for all patients.ResultsPARP-1 gene expression level showed a significant difference in comparing the three groups, with the highest level being for the (ON+) group (p<0.0009). Significant negative correlations were found between PARP-1 gene expression level and central macular thickness, total macular volume and full foveal vessel density thickness. ROC curve constructed by plotting the area under the receiver operating characteristic curve value was (0.9) for PARP-1 gene expression level.ConclusionsPARP-1 may play an important role in the development of the ON cascade in patients with MS and may be a biomarker for diagnosing and a potential molecular target of ON in MS patients’ therapy. In addition to the OCT and OCT-angio changes that could be detected retrospectively, PARP-1 gene expression level could be considered a prospective detector to complete the full-blown picture of MS (ON+) early and prevent blindness.
Hurricane Florence and suicide mortality in North Carolina: a controlled interrupted time-series analysis
Authors: Miller Vanessa Eve , Pence Brian W , Fitch Kate Vinita , Swilley-Martinez Monica , Kavee Andrew L , Dorris Samantha , Cooper Toska , Keil Alexander P , Gaynes Bradley N , Carey Timothy S , Goldston David , Ranapurwala Shabbar 
Published: December 2022

BackgroundNatural disasters are associated with increased mental health disorders and suicidal ideation; however, associations with suicide deaths are not well understood. We explored how Hurricane Florence, which made landfall in September 2018, may have impacted suicide deaths in North Carolina (NC).MethodsWe used publicly available NC death records data to estimate associations between Hurricane Florence and monthly suicide death rates using a controlled, interrupted time series analysis. Hurricane exposure was determined by using county-level support designations from the Federal Emergency Management Agency. We examined effect modification by sex, age group, and race/ethnicity.Results8363 suicide deaths occurred between January 2014 and December 2019. The overall suicide death rate in NC between 2014 and 2019 was 15.53 per 100 000 person-years (95% CI 15.20 to 15.87). Post-Hurricane, there was a small, immediate increase in the suicide death rate among exposed counties (0.89/100 000 PY; 95% CI −2.69 to 4.48). Comparing exposed and unexposed counties, there was no sustained post-Hurricane Florence change in suicide death rate trends (0.02/100 000 PY per month; 95% CI −0.33 to 0.38). Relative to 2018, NC experienced a statewide decline in suicides in 2019. An immediate increase in suicide deaths in Hurricane-affected counties versus Hurricane-unaffected counties was observed among women, people under age 65 and non-Hispanic black individuals, but there was no sustained change in the months after Hurricane Florence.ConclusionsAlthough results did not indicate a strong post-Hurricane Florence impact on suicide rates, subgroup analysis suggests differential impacts of Hurricane Florence on several groups, warranting future follow-up.
Prevalence and treatment of diabetes and pre-diabetes in a real-world heart failure population: a single-centre cross-sectional study
Authors: Håkansson Erik , Brunström Mattias , Norberg Helena , Själander Sara , Lindmark Krister 
Published: December 2022

AimsThe aim of this study was to investigate a real-world heart failure (HF) cohort regarding (1) prevalence of known diabetes mellitus (DM), undiagnosed DM and pre-diabetes, (2) if hf treatment differs depending on glycaemic status and (3) if treatment of DM differs depending on HF phenotype.MethodsAll patients who had received a diagnosis of HF at Umeå University Hospital between 2010 and 2019 were identified and data were extracted from patient files according to a prespecified protocol containing parameters for clinical characteristics, including echocardiogram results, comorbidities, fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) values. Patients’ HF phenotype was determined using the latest available echocardiogram. The number of patients with previous DM diagnosis was assessed. Patients without a previous diagnosis of DM were classified as non-DM, pre-diabetes or probable DM according to FPG and HbA1c levels using WHO criteria.ResultsIn total, 2326 patients (59% male, mean age 76±13 years) with HF and at least one echocardiogram were assessed. Of these, 617 (27%) patients had a previous diagnosis of DM. Of the 1709 patients without a previous diagnosis of DM, 1092 (67%) patients had either an FPG or HbA1c recorded, of which 441 (41%) met criteria for pre-diabetes and 97 (9%) met criteria for probable diabetes, corresponding to 19% and 4% of the entire cohort, respectively. Patients with HF and diabetes were more often treated with diuretics and beta blockers compared with non-DM patients (64% vs 42%, p<0.001 and 88% vs 83%, p<0.001, respectively). There was no difference in DM treatment between HF phenotypes.ConclusionsDM and pre-diabetes are common in this HF population with 50% of patients having either known DM, probable DM or pre-diabetes. Patients with HF and DM are more often treated with common HF medications. HF phenotype did not affect choice of DM therapy.
Lipid lowering with inclisiran: a real-world single-centre experience
Authors: Padam Pritpal , Barton Lucy , Wilson Stewart , David Alessia , Walji Shahenaz , de Lorenzo Ferruccio , Ray Kausik K , Jones Ben , Cegla Jaimini 
Published: December 2022

ObjectiveThe reduction in circulating low-density lipoprotein cholesterol (LDL-c) is the primary aim of lipid-lowering therapies as a method of atherosclerotic cardiovascular disease risk reduction. Inclisiran is a new and potent lipid-lowering drug that is shown to be effective in reducing LDL-c in randomised controlled trials, however, real-world data of its use are not yet known. We sought to analyse the early effects of this drug in a tertiary centre lipid and cardiovascular risk clinic.MethodsWe performed a retrospective analysis of the first 80 patients who received a single dose of inclisiran at our lipid clinic between 1 December 2021 and 1 September 2022. Data were collected using electronic healthcare records. Baseline blood tests were taken prior to start of treatment and were repeated at 2 months follow-up. Data on adverse events were also recorded.ResultsAt 2 months after treatment initiation, mean baseline LDL-c fell from 3.5±1.1 mmol/L by 48.6% to 1.8±1.0 mmol/L and total cholesterol from 5.7±1.3 mmol/L by 33.3% to 3.8±1.1 mmol/L (both p<0.0001). Mean high-density lipoprotein-c rose by 7.7% to 1.4±0.4 mmol/L (p=0.02) and median triglycerides fell by 31.3% to 1.1 mmol/L (IQR 0.9–2) (p=0.001). Adverse events (injection site reaction, fatigue and headache) were recorded in three patients and all had self-resolved by time of follow-up.ConclusionInclisiran use in line with National Institute for Health and Care Excellence guidelines led to significant lowering of LDL-c at 2 months, with efficacy similar to that reported in trials with good tolerability.
Acceptable risks of treatments to prevent rheumatoid arthritis among first-degree relatives: demographic and psychological predictors of risk tolerance
Authors: Simons Gwenda , Janssen Ellen M , Veldwijk Jorien , DiSantostefano Rachael L , Englbrecht Matthias , Radawski Christine , Valor-Méndez Larissa , Humphreys Jennifer H , Bruce Ian N , Hauber Brett , Raza Karim , Falahee Marie 
Published: December 2022

ObjectivesTo quantify tolerance to risks of preventive treatments among first-degree relatives (FDRs) of patients with rheumatoid arthritis (RA).MethodsPreventive treatments for RA are under investigation. In a preference survey, adult FDRs assumed a 60% chance of developing RA within 2 years and made choices between no treatment and hypothetical preventive treatment options with a fixed level of benefit (reduction in chance of developing RA from 60% to 20%) and varying levels of risks. Using a probabilistic threshold technique, each risk was increased or decreased until participants switched their choice. Perceived risk of RA, health literacy, numeracy, Brief Illness Perception Questionnaire and Beliefs about Medicines Questionnaire-General were also assessed. Maximum acceptable risk (MAR) was summarised using descriptive statistics. Associations between MARs and participants’ characteristics were assessed using interval regression with effects coding.Results289 FDRs (80 male) responded. The mean MAR for a 40% reduction in chance of developing RA was 29.08% risk of mild side effects, 9.09% risk of serious infection and 0.85% risk of a serious side effect. Participants aged over 60 years were less tolerant of serious infection risk (mean MAR ±2.06%) than younger participants. Risk of mild side effects was less acceptable to participants who perceived higher likelihood of developing RA (mean MAR ±3.34%) and more acceptable to those believing that if they developed RA it would last for a long time (mean MAR ±4.44%).ConclusionsAge, perceived chance of developing RA and perceived duration of RA were associated with tolerance to some risks of preventive RA therapy.
Fission-stability of high-K states in superheavy nuclei
Authors: Khuyagbaatar J. 
Published: December 2022

AbstractFission is the one of the primary radioactive decay modes for the heaviest nuclei and ultimately determines the existence of the heaviest elements on a macroscopic time scale, e.g., $$\ge 10^{-14}$$

≥

10

-
14

s. The present experimental data on the decay properties of the heaviest nuclei with proton numbers 102–118 and/or of neutron numbers up to 177 show that fission occurs occasionally. This confirms that shell structure plays an essential role for their stability against fission. The shell effect on fission manifests in both collective and single-particle ways, which can experimentally be studied in decays of even–even, odd-A and odd–odd nuclei. At the same time, high-K states formed in couplings of quasiparticles are also known to be stable against fission. However, detailed knowledge and theoretical descriptions on a retardation effect/strength of high-K quantum number on fission are still scarce. In the present work, fission from high-K states are discussed and described within the semi-empirical approach. Fission half-lives are calculated for various high-K states, which have been theoretically predicted to exist in Fm-Rf (Z = 100–104) and Hs-Ds (Z = 108–112). The results are found to be in line with the available experimental findings, and also leading to different intriguing predictions, e.g., high-K states in superheavy nuclei tend to be more stable against fission compared to their ground states.
Study of Noether symmetry analysis for a cosmological model with variable G and $$\Lambda $$ gravity theory
Authors: Bhaumik Roshni , Dutta Sourav , Chakraborty Subenoy 
Published: December 2022

AbstractIn this present model we have discussed about the solution of the matter-dominated cosmological equations using the expression of $$\Lambda =\Lambda (G)$$

Λ
=
Λ
(
G
)

. Using Noether symmetry analysis we have analyzed both the classical and quantum cosmology. We have made a suitable point transformation in order to make one variable cyclic. As a result the evolution equations become simpler to solve. Wheeler–DeWitt (WD) equation has been constructed for this cosmological model and using conserved charge we have found the solution of WD equation. Finally the solutions have been analyzed in the cosmological point of view.
A reconstruction method for anisotropic universes in unimodular F(R)-gravity
Authors: Costantini A. , Elizalde E. 
Published: December 2022

AbstractAn extension of unimodular Einsteinian gravity in the context of F(R) gravities is used to construct a class of anisotropic evolution scenarios. In unimodular GR the determinant of the metric is constrained to be a fixed number or a function. However, the metric of a generic anisotropic universe is not compatible with the unimodular constraint, so that a redefinition of the metric, to properly take into account the constraint, need be performed. The unimodular constraint is imposed on F(R) gravity in the Jordan frame by means of a Lagrangian multiplier, to get the equations of motion. The resulting equations can be viewed as a reconstruction method, which allows to determine what function of the Ricci scalar can realize the desired evolution. For the sake of clarity, some characteristic examples are invoked to show how this reconstruction method works explicitly. The de Sitter spacetime here considered, in the context of unimodular F(R) gravity, is suitable to describe both the early- and late-time epochs of the universe history.