bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthcare institutions’ recommendation regarding the use of FFP-2 masks and SARS-CoV-2 seropositivity among healthcare workers: a multicenter longitudinal cohort study
Authors: Szajek Katarzyna , Fleisch Felix , Hutter Sandra , Risch Martin , Bechmann Theresa , Luyckx Valerie A. , Güsewell Sabine , Hirzel Cédric , Cusini Alexia , Group AMICO Study ,   AMICO Study Group, Eronat Vedat , Eichweber Luwina , von Fellenberg Theodor , Albertini Mauro , Flury Gian , Brüggen Marie-Charlotte , Schneeberger Andres , Koch Thomas , Genoni Michele , Kistler Walter , Egger Patrick 
Published: January 2022

Abstract
Background
Health care workers (HCW) are heavily exposed to SARS-CoV-2 from the beginning of the pandemic. We aimed to analyze risk factors for SARS-CoV-2 seroconversion among HCW with a special emphasis on the respective healthcare institutions’ recommendation regarding the use of FFP-2 masks.

Methods
We recruited HCW from 13 health care institutions (HCI) with different mask policies (type IIR surgical face masks vs. FFP-2 masks) in Southeastern Switzerland (canton of Grisons). Sera of participants were analyzed for the presence of SARS-CoV-2 antibodies 6 months apart, after the first and during the second pandemic wave using an electro-chemiluminescence immunoassay (ECLIA, Roche Diagnostics). We captured risk factors for SARS-CoV-2 infection by using an online questionnaire at both time points. The effects of individual COVID-19 exposure, regional incidence and FFP-2 mask policy on the probability of seroconversion were evaluated with univariable and multivariable logistic regression.

Results
SARS-CoV-2 antibodies were detected in 99 of 2794 (3.5%) HCW at baseline and in 376 of 2315 (16.2%) participants 6 months later. In multivariable analyses the strongest association for seroconversion was exposure to a household member with known COVID-19 (aOR: 19.82, 95% CI 8.11–48.43, p < 0.001 at baseline and aOR: 8.68, 95% CI 6.13–12.29, p < 0.001 at follow-up). Significant occupational risk factors at baseline included exposure to COVID-19 patients (aOR: 2.79, 95% CI 1.28–6.09, p = 0.010) and to SARS-CoV-2 infected co-workers (aOR: 2.50, 95% CI 1.52–4.12, p < 0.001). At follow up 6 months later, non-occupational exposure to SARS-CoV-2 infected individuals (aOR: 2.54, 95% CI 1.66–3.89 p < 0.001) and the local COVID-19 incidence of the corresponding HCI (aOR: 1.98, 95% CI 1.30–3.02, p = 0.001) were associated with seroconversion. The healthcare institutions’ mask policy (surgical masks during usual exposure vs. general use of FFP-2 masks) did not affect seroconversion rates of HCW during the first and the second pandemic wave.

Conclusion
Contact with SARS-CoV-2 infected household members was the most important risk factor for seroconversion among HCW. The strongest occupational risk factor was exposure to COVID-19 patients. During this pandemic, with heavy non-occupational exposure to SARS-CoV-2, the mask policy of HCIs did not affect the seroconversion rate of HCWs.
Multifocality and opportunity structure: towards a mixed embeddedness model for transnational migrant entrepreneurship
Authors: Solano Giacomo , Schutjens Veronique , Rath Jan 
Published: January 2022

AbstractThis article addresses transnational migrant entrepreneurship, which refers to migrants involved in cross-border entrepreneurial activities. Previous models and concepts in migrant entrepreneurship studies have not fully succeeded in recognising the role played by differential groups and places in the pursuit of opportunities by transnational migrant entrepreneurs. This is due to a tendency to focus on the country of residence as well as on the inclination to view migrant entrepreneurs as members of a coherent ethnic or national group. To help fill this gap, we propose a new model combining the concept of multifocality, covering the simultaneous involvement of migrant entrepreneurs in both multiple places and multiple groups, with group modes of behaviour as an additional dimension influencing the opportunity structure. The case of Moroccan transnational entrepreneurs in Amsterdam shows that the role of multifocality in place, in combination with group modes of behaviour, is critical when it comes to pursuing entrepreneurial opportunities.
Volumetric comparative analysis of anatomy through far-lateral approach: surgical space and exposed tissues
Authors: Tang Ke , Feng Xu , XiaodongYuan  , Li Yang , XinyueChen  
Published: January 2022

Abstract
Background
The three-dimensional (3D) visualization model has ability to quantify the surgical anatomy of far-lateral approach. This study was designed to disclose the relationship between surgical space and exposed tissues in the far-lateral approach by the volumetric analysis of 3D model.

Methods
The 3D skull base models were constructed using MRI and CT data of 15 patients (30 sides) with trigeminal neuralgia. Surgical corridors of the far-lateral approach were simulated by triangular pyramids to represent two surgical spaces exposing bony and neurovascular tissues. Volumetric comparison of surgical anatomy was performed using pair t test.

Results
The morphometric results were almost the same in the two surgical spaces except the vagus nerve (CN X) exposed only in one corridor, whereas the volumetric comparison represented the statistical significant differences of surgical space and bony and neurovascular tissues involved in the two corridors (P<0.001). The differences of bony and neurovascular tissues failed to equal the difference of surgical space.

Conclusions
For far-lateral approach, the increase of exposure for the bony and neurovascular tissues is not necessarily matched with the increase of surgical space. The volumetric comparative analysis is helpful to provide more detailed anatomical information in the surgical design.
Patient-reported outcomes version of the common terminology criteria for adverse events and quality-of-life linear analogue self-assessment in breast cancer patients receiving radiation therapy: single-institution prospective registry
Authors: Thorpe C. S. , DeWees T. A. , Golafshar M. A. , Bhangoo R. S. , Vern-Gross T. Z. , McGee L. A. , Wong W. W. , Halyard M. Y. , Keole S. R. , Vargas C. E. 
Published: January 2022

Abstract
Purpose/objectives
We sought to investigate the impact of patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE) on overall quality-of-life (QOL) employing linear analogue self-assessment (LASA) in breast cancer (BC) patients undergoing radiation therapy (RT).

Materials/methods
All patients treated with RT for BC with curative intent from 2015 to 2019 at our institution were included. Breast specific PRO-CTCAE and overall QOL LASA questionnaires were administered at baseline, end-of-treatment, 3, 6, 12 months, and then annually. Minimal clinically important difference in overall QOL was a 10-point change in LASA. Hypofractionation was any treatment > 2 Gy per fraction. Mixed models for repeated measures were used to determine the association of PRO-CTCAE and overall QOL LASA.

Results
Three hundred thirty-one (331) patients with a median follow-up of 3.1 years (range 0.4–4.9) were included. Average overall QOL LASA scores were 78.5 at baseline, 79.8 at end-of-treatment, 79.8 at 3 months, 77.1 at 6 months, 79.4 at 12 months, and 79.7 at 24 months. On univariate analysis, patients reporting a grade ≥ 3 PRO-CTCAE had, on average, a 10.4-point reduction in overall LASA QOL (p < 0.0001). On multivariate analysis, not being treated with hypofractionation and higher BMI were predictive for worse overall LASA QOL with a 10-point reduction in LASA for patients reporting a grade ≥ 3 PRO-CTCAE (p < 0.0001).

Conclusions
Patients reporting a grade ≥ 3 PRO-CTCAE experienced statistically significant and clinically meaningful deterioration in overall QOL LASA. Hypofractionation improved QOL while higher BMI predicted for worse QOL. PRO-CTCAE should be integrated into future clinical trials.
In silico profiling of histone deacetylase inhibitory activity of compounds isolated from Cajanus cajan
Authors: Adewole Kayode , Ishola Adebayo , Olaoye Ige 
Published: January 2022

AbstractBackgroundCancer is responsible for high morbidity and mortality globally. Because the overexpression of histone deacetylases (HDACs) is one of the molecular mechanisms associated with the development and progression of some diseases such as cancer, studies are now considering inhibition of HDAC as a strategy for the treatment of cancer. In this study, a receptor-based in silico screening was exploited to identify potential HDAC inhibitors among the compounds isolated fromCajanus cajan, since reports have earlier confirmed the antiproliferative properties of compounds isolated from this plant.ResultsCajanus cajan-derived phytochemicals were docked with selected HDACs, with givinostat as the reference HDAC inhibitor, using AutodockVina and Discovery Studio Visualizer, BIOVIA, 2020. Furthermore, absorption, distribution, metabolism and excretion (ADME) drug-likeness analysis was done using the Swiss online ADME web tool. From the results obtained, 4 compounds; betulinic acid, genistin, orientin and vitexin, were identified as potential inhibitors of the selected HDACs, while only 3 compounds (betulinic acid, genistin and vitexin) passed the filter of drug-likeness. The molecular dynamic result revealed the best level of flexibility on HDAC1 and HDAC3 compared to the wild-type HDACs and moderate flexibility of HDAC7 and HDAC8.ConclusionsThe results of molecular docking, pharmacokinetics and molecular dynamics revealed that betulinic acid might be a suitable HDAC inhibitor worthy of further investigation in order to be used for regulating conditions associated with overexpression of HDACs. This knowledge can be used to guide experimental investigation onCajanus cajan-derived compounds as potential HDAC inhibitors.
Evaluation of seaweed sulfated polysaccharides as natural antagonists targeting Salmonella typhi OmpF: molecular docking and pharmacokinetic profiling
Authors: Arunkumar Malaisamy , Mahalakshmi Murugan , Ashokkumar Vairamuthu , Aravind Manikka Kubendran , Gunaseelan Sathaiah , Mohankumar Verma , Ashokkumar Balasubramaniem , Varalakshmi Perumal 
Published: January 2022

Abstract
Background
Salmonella belongs to the Enterobacteriaceae family, a gram-negative, non-spore-forming, rod-shaped, motile, and pathogenic bacteria that transmit through unhygienic conditions. It is estimated that 21 million new infections arise every year, resulting in approximately 200,000 deaths. It is more prevalent among children, the old aged, and immunocompromised individuals. The frequent usage of classical antimicrobials has begun the increasing emergence of various drug-resistant pathogenic bacterial strains. Hence, this study was intended to evaluate the bioactive seaweed sulfated polysaccharides (SSPs) against the ompF (outer membrane porin F) protein target of Salmonella typhi. SSP is the sulfated compound with a wide range of biological activities, such as anti-microbial, anti-allergy, anti-cancer, anti-coagulant, anti-inflammation, anti-oxidant, and anti-viral.

Results
In this study, eleven compounds were targeted against S. typhi OmpF by the molecular docking approach and were compared with two commercially available typhoid medications. The SSP showed good binding affinity compared to commercial drugs, particularly carrageenan/MIV-150, carrageenan lambda, fucoidan, and 3-phenyllactate, ranked as top antagonists against OmpF. Further, pharmacokinetics and toxicology (ADMET) studies corroborated that SSP possessed drug-likeness and highly progressed in all parameters.

Conclusions
AutoDockTools and Schrodinger's QikProp module results suggest that SSP could be a promising drug for extensively drug-resistant (XDR) S. typhi. To the best of our knowledge, this is the first report on in silico analysis of SSP against S. typhi OmpF, thus implying the capabilities of SSPs especially compounds like carrageenans, as a potential anti-microbial agent against Salmonella typhi infections. Eventually, advanced studies could corroborate SSPs to the next level of application in the crisis of XDR microbial diseases.

Graphical Abstract
Thermoelectric performance of MoSi2As4monolayer
Authors: Huang Yuhong , Zhong Xuanhong , Yuan Hongkuan , Chen Hong 
Published: January 2022

Abstract
Thermoelectric performance of MoSi2As4 monolayer is investigated using density functional theory combined with Boltzmann transport theory. The maximal power factors of n- and p-type by the PBE (HSE06) functional are 7.73 (48.31) and 32.84

at the temperature of 1200 K, respectively. The lattice thermal conductivity is less than

above 800 K. The thermoelectric figure of merit can reach 0.33 (0.58) and 0.90 (0.81) using the PBE (HSE06) functional for n- and p-type under appropriate carrier concentration at 1200 K, respectively. Thus, the p-type MoSi2As4 monolayer is predicted to be a potential candidate for high-temperature thermoelectric applications.
TMEM8C-mediated fusion is regionalized and regulated by NOTCH signalling during foetal myogenesis
Authors: Esteves de Lima Joana , Blavet Cédrine , Bonnin Marie-Ange , Hirsinger Estelle , Havis Emmanuelle , Relaix Frédéric , Duprez Delphine 
Published: January 2022

ABSTRACT
The location and regulation of fusion events within skeletal muscles during development remain unknown. Using the fusion marker myomaker (Mymk), named TMEM8C in chicken, as a readout of fusion, we identified a co-segregation of TMEM8C-positive cells and MYOG-positive cells in single-cell RNA-sequencing datasets of limbs from chicken embryos. We found that TMEM8C transcripts, MYOG transcripts and the fusion-competent MYOG-positive cells were preferentially regionalized in central regions of foetal muscles. We also identified a similar regionalization for the gene encoding the NOTCH ligand JAG2 along with an absence of NOTCH activity in TMEM8C+ fusion-competent myocytes. NOTCH function in myoblast fusion had not been addressed so far. We analysed the consequences of NOTCH inhibition for TMEM8C expression and myoblast fusion during foetal myogenesis in chicken embryos. NOTCH inhibition increased myoblast fusion and TMEM8C expression and released the transcriptional repressor HEYL from the TMEM8C regulatory regions. These results identify a regionalization of TMEM8C-dependent fusion and a molecular mechanism underlying the fusion-inhibiting effect of NOTCH in foetal myogenesis. The modulation of NOTCH activity in the fusion zone could regulate the flux of fusion events.
Olga Katsiardi-Hering (ed.), Βενετικοί χάρτες της Πελοποννήσου, τέλη 17ου–αρχές 18ου αιώνα: Από τη συλλογή του Πολεμικού Αρχείου της Αυστρίας [Venetian maps of the Peloponnese, late 17th–early 18th centuries: From the Austrian War Archive collection]
Authors: Festas Michael 
Published: January 2022

Review of: Olga Katsiardi-Hering (ed.), Βενετικοί χάρτες της Πελοποννήσου, τέλη 17ου–αρχές 18ου αιώνα: Από τη συλλογή του Πολεμικού Αρχείου της Αυστρίας [Venetian maps of the Peloponnese, late 17th–early 18th centuries: From the Austrian War Archive collection]
Wyniki badań nieinwazyjnych na zamkach krzyżackich w Starogrodzie, Unisławiu, Zamku Bierzgłowskim i Lipienku
Authors: Misiewicz Krzysztof , Bogacki Miron , Małkowski Wiesław , Wiewióra Marcin , Cisło Radosław 
Published: January 2022

W artykule zaprezentowano wyniki badań nieinwazyjnych, realizowanych w ramach projektu naukowego pt. „Castra Terrae Culmensis – na rubieży chrześcijańskiego świata”. Obejmowały one szerokopłaszczyznowe rozpoznanie za pomocą pomiarów magnetometrycznych i geofizycznych oraz naziemny skaning laserowy, które stanowiły podstawą do badań archeologicznych, prowadzonych w 2017 i 2018 roku.
Corporate Diversification and Risk: Portfolio Effects and Resource Redeployability
Authors: Sakhartov Arkadiy V. 
Published: January 2022

By analogy with portfolio diversification by stock market investors, managers and researchers have often expected that firms that spread operations across product or geographic markets reduce risk. However, numerous exploratory studies in corporate strategy and in international business have not been able to robustly confirm this expectation. This study develops a formal model to scrutinize implications of corporate diversification for corporate risk. The model incorporates the key distinction of corporate diversification, economies of scope, that qualifies the analogy between corporate and portfolio diversification. The presence of a particular type of economies of scope, resource redeployability, not only inherently increases risk but it can also raise risk over the level in undiversified firms. The model uses determinants of resource redeployability from previous research to derive conditions with which corporate diversification enhances risk. The developed elaborate operationalization of corporate risk should facilitate future research and help corporate managers.Supplemental Material: The online appendix is available at https://doi.org/10.1287/stsc.2021.0154 .
City Branding: communication and marketing strategy for an island urban policy
Authors: Del-Ponti Patricia , Barrientos-Báez Almudena , Caldevilla-Domínguez David 
Published: January 2022

Hoy en día, en la conocida “Sociedad de la Información”, nadie puede dudar de que el marketing y la comunicación dentro de una ciudad turística son cruciales para su existencia y desarrollo. Por ello, la investigación de la marca de la ciudad ha incrementado el interés en la literatura internacional durante los últimos años. El presente artículo se centra en la implementación de una estrategia competitiva de marca de lugar en el caso de Santa Cruz de Tenerife, una capital insular de tamaño medio para explorar el mecanismo central de este fenómeno, desde una perspectiva aplicada y como resultado de la experiencia adquirida en varios proyectos de transferencia de conocimiento liderados por los autores. Específicamente, el objetivo de esta investigación fue identificar y analizar las condiciones actuales que prevalecen en la capital de una isla periférica junto a las posibles colaboraciones entre los interesados. Una extensa investigación bibliográfica sobre el destino y la marca de la ciudad, así como estudios de casos exitosos de otras ciudades, llevaron a la formación del panel de discusión. También se lleva a cabo una investigación cualitativa, desarrollando entrevistas en profundidad con actores locales, líderes de opinión de la Administración pública y emprendedores del sector privado.
The Concept of "Women's Rights" and Constitutional Freedom of Labor: Terminology Clarifications and Implementation Problems
Authors: Golovinov Alexandr , Golovinova Yulia 
Published: January 2022

The publication is aimed at defining the essence of the concept of "women's rights". The article shows that the concept of “women's rights” is widely used in the system of normative legal acts in Russia. The domestic legislator, resolutely opposing gender asymmetry, understands the rights of women as a system of integral and inalienable rights, freedoms and obligations for every woman, girl, adolescent girl, regardless of her age, citizenship, race, ethnic or religious affiliation.
Using hermeneutic tools, an attempt is made to show the content and problems of the implementation of the labor rights of females. The article emphasizes that horizontal segregation develops under the influence of many factors due to the mentality and preference of various types of activities for men and women. Ultimately, women in general end up with lower income jobs.
The authors found that the problems in Russia are the separation of professions into "male" and "female", which entails different wages; the feminization of poverty and unemployment; horizontal professional mobility for women. The increasing number of appeals associated with the violation of the socio-economic rights of women and their making the most of their labor potential become the subject of justice, in particular of constitutional justice in the Russian Federation.
Отношение к мигрантам: мнения и сомнения россиян
Authors: Монусова Галина Алексеевна 
Published: January 2022

Данное исследование акцентирует внимание на отношении россиян к мигрантам, которое измеряется через согласие/несогласие индивида позволить людям разной этнической принадлежности переезжать жить в нашу страну. На базе данных Европейского социального обследования (ESS) за 2006—2018 гг. проведен анализ, результаты которого свидетельствуют о том, что толерантность к мигрантам тесно связана, с одной стороны, с уровнем образования индивидов, а с другой — с его системой взглядов на окружающий социальный мир, которая может строиться как на иррациональных предубеждениях и страхах, так и на рациональном мышлении, научном знании и вере в себя. Если индивид воспринимает мир настороженно, склонен к предубеждениям и страхам, никому не доверяет и считает, что его окружает несправедливость, то высока вероятность неприятия и отторжения мигрантов. В то же время самодостаточность и вера в собственные силы будут сопровождаться большей толерантностью ко всему малоизвестному, включая выходцев из других стран.
Благодарность. Статья подготовлена при поддержке Программы фундаментальных и прикладных научных исследований по теме «Этнокультурное многообразие российского общества и укрепление общероссийской идентичности» 2020–2022 гг.
Автор признателен В. Магуну, В. Мукомелю и анонимным рецензентам за полезные замечания и комментарии.
Profesní učitelské učení a reflexe studentského portfolia
Authors: Lukášová Hana 
Published: January 2022

Studie bude sledovat, jak jsme v posledních desetiletích svědky stále naléhavějšího hledání nových cest ve vyhodnocování výsledků inovovaného studia učitelství na univerzitách v České republice i v zahraničí. Při interpretaci změn narážíme na různé potíže teoretické, metodologické, praktické a výzkumné.
Výraznou změnou učitelské edukace byl přechod na pětileté magisterské studium oboru Učitelství pro 1. stupeň základních škol, který prošel náročnou diskusí se zástupci vzdělávací politiky v České republice – viz slyšení v Senátu ČR v roce 2002. Zaměřuje se na preferenci profesního učitelského rozvoje po dobu celých pěti let studia učitelství. V této stati se budeme věnovat změně profesního učitelského učení pouze z jednoho zorného úhlu – jako důkazu o výsledku změny na základě předchozích diskusí vzdělávací politiky. Budeme sledovat studentské portfolio jako kvalitativní nástroj k hodnocení a sebehodnocení studentů učitelství pro první stupeň základní školy v průběhu a závěru studia. Rozebereme teoretická východiska volby portfolií jako nástroje ke sledování profesního učení vědního oboru pedagogika v rámci přípravy na učitelství v primární edukaci. Reflexe studentského portfolia může být dokladem, který zachycuje individuální strategie studentů při osvojování pedagogické teorie z primární pedagogiky a hodnocení výsledků reflektované pedagogické praxe. Pedagogická praxe prostupuje spolu s pedagogickou teorií od prvního ročníku pětiletého studia Učitelství pro 1. stupeň základní školy v novém modelu učitelské přípravy ve Zlíně na Fakultě humanitních studií Univerzity Tomáše Bati. V tomto roce jsou dispozici první výsledky reflexe nově zvolené cesty učitelské přípravy. Vyplývají z nich i zajímavé podněty pro vzdělávací politiku ve vztahu k učitelské přípravě v České republice do budoucna.