bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteoclasts directly influence castration-resistant prostate cancer cells
Authors: Huang Junchi , Freyhult Eva , Buckland Robert , Josefsson Andreas , Damber Jan-Erik , Welén Karin 
Published: August 2022

AbstractMetastasis to bone is the leading cause of death from prostate cancer. Interaction between tumor cells and bone cells can promote progression and influence tumor phenotype. It is known that prostate cancer cells support osteoclast differentiation, and degradation of bone matrix by osteoclasts releases growth factors stimulating tumor cell proliferation and invasion. In the present study osteolytic (PC-3) and osteoblastic (LNCaP-19) castration-resistant prostate cancer (CRPC) cells were co-cultured with mature osteoclasts or their precursor cells (RAW 264.7) to characterize direct effects of mature osteoclasts on CRPC cells. Osteoclasts increased proliferation and decrease apoptosis of CRPC cells as assessed with flow cytometry. RNA sequencing revealed that osteolytic CRPC cells were more responsive to osteoclast stimulation regarding gene expression, but the overall induced expression patterns were similar between the prostate cancer cell lines. Genes related to DNA repair were upregulated by osteoclasts, while genes related to endoplasmic reticulum stress-induced apoptosis and cholesterol synthesis were downregulated. The results of this study shows that osteoclasts directly influence CRPC cells, increasing proliferation, decreasing apoptosis, and affecting gene expression pathways that can affect sensitivity to DNA damage and endoplasmic reticulum function. This suggests targeting of osteoclasts to be a possible way to affect efficacy of other drugs by combination regimens in treating prostate cancer metastases.
Dynamic connectedness of green bond with financial markets of European countries under OECD economies
Authors: Yadav Miklesh , Mishra Nandita , Ashok Shruti 
Published: August 2022

AbstractThis paper examines the dynamic connectedness between green bonds and OECD financial markets of European countries. The study is conducted on daily price of green bonds and selected European stock markets from January 27, 2015, to August 4, 2021. Top ten European countries namely Luxembourg, Switzerland, Norway, Denmark, Germany, Netherlands, Iceland, Austria, Sweden, and Belgium are included within the OECD economies. The study uses Diebold and Yilmaz and Barunik & Krehlic tests to examine the connectedness between the economies and green bonds in short, medium, and long term. Result exhibits volatility across all frequency cycles. Brussel Stock Exchange and Euronext Amsterdam are identified as high-risk markets in the OECD European market. Evidence emerging from this study advocate the inclusion of green bonds in these financial markets for shorter time periods only. Results from this study are expected to have practical implications for portfolio managers, investors, and market regulators, suggesting incorporation of green bonds in investor portfolio for efficient diversification of risk.
Pure and mixed lexicographic-paretian many-objective optimization: state of the art
Authors: Lai Leonardo , Fiaschi Lorenzo , Cococcioni Marco , Deb Kalyanmoy 
Published: August 2022

AbstractThis work aims at reviewing the state of the art of the field of lexicographic multi/many-objective optimization. The discussion starts with a review of the literature, emphasizing the numerous application in the real life and the recent burst received by the advent of new computational frameworks which work well in such contexts, e.g., Grossone Methodology. Then the focus shifts on a new class of problems proposed and studied for the first time only recently: the priority-levels mixed-pareto-lexicographic multi-objective-problems (PL-MPL-MOPs). This class of programs preserves the original preference ordering of pure many-objective lexicographic optimization, but instantiates it over multi-objective problems rather than scalar ones. Interestingly, PL-MPL-MOPs seem to be very well qualified for modeling real world tasks, such as the design of either secure or fast vehicles. The work also describes the implementation of an evolutionary algorithm able to solve PL-MPL-MOPs, and reports its performance when compared against other popular optimizers.
Feature selection algorithm based on P systems
Authors: Song Hongping , Huang Yourui , Song Qi , Han Tao , Xu Shanyong 
Published: August 2022

AbstractSince the number of features of the dataset is much higher than the number of patterns, the higher the dimension of the data, the greater the impact on the learning algorithm. Dimension disaster has become an important problem. Feature selection can effectively reduce the dimension of the dataset and improve the performance of the algorithm. Thus, in this paper, A feature selection algorithm based on P systems (P-FS) is proposed to exploit the parallel ability of cell-like P systems and the advantage of evolutionary algorithms in search space to select features and remove redundant information in the data. The proposed P-FS algorithm is tested on five UCI datasets and an edible oil dataset from practical applications. At the same time, the P-FS algorithm and genetic algorithm feature selection (GAFS) are compared and tested on six datasets. The experimental results show that the P-FS algorithm has good performance in classification accuracy, stability, and convergence. Thus, the P-FS algorithm is feasible in feature selection.
Conscientiousness as a Predictor of the Gender Gap in Academic Achievement
Authors: Verbree Anne-Roos , Hornstra Lisette , Maas Lientje , Wijngaards-de Meij Leoniek 
Published: August 2022

AbstractIn recent decades, female students have been more successful in higher education than their male counterparts in the United States and other industrialized countries. A promising explanation for this gender gap are differences in personality, particularly higher levels of conscientiousness among women. Using Structural Equation Modeling on data from 4719 Dutch university students, this study examined to what extent conscientiousness can account for the gender gap in achievement. We also examined whether the role of conscientiousness in accounting for the gender gap differed for students with a non-dominant ethnic background compared to students with a dominant ethnic background. In line with our expectations, we found that conscientiousness fully mediated the gender gap in achievement, even when controlling for prior achievement in high school. This was the case among both groups of students. These findings provide insight into the mechanisms underlying the gender gap in achievement in postsecondary education settings. The current study suggests that the use of conscientiousness measures in university admission procedures may disadvantage male students. Instead, the use of such measures may be a fruitful way to identify those students who may benefit from interventions to improve their conscientiousness. Future research could examine how conscientiousness can be fostered among students who are low in conscientiousness.
Ischemic Cardiomyopathy and Heart Failure After Acute Myocardial Infarction
Authors: Del Buono Marco Giuseppe , Moroni Francesco , Montone Rocco Antonio , Azzalini Lorenzo , Sanna Tommaso , Abbate Antonio 
Published: August 2022

Abstract
Purpose of Review
Ischemic cardiomyopathy refers to systolic left ventricular dysfunction in the setting of obstructive coronary artery disease and represents the most common cause of heart failure worldwide. It is often the combination of an irreversible loss of viable mass following an acute myocardial infarction (AMI) with a dysfunctional, but still viable, myocardium in the context of a chronically reduced myocardial blood flow and reduced coronary reserve. Medical treatments aiming at modulating neurohumoral response and restoring blood flow to the ischemic cardiomyocytes were shown to dramatically abate the occurrence of ventricular dysfunction and adverse remodeling in ischemic cardiomyopathy.

Recent Findings
Novel therapeutic approaches, such as mechanical unloading and modulation of the inflammatory response, appear to be promising. Furthermore, the understanding of the mechanisms by which, despite optimal treatment, heart failure ensues after AMI, with or without adverse remodeling and systolic dysfunction, is a critical step in the search for novel ways to tackle heart failure risk beyond preservation of left ventricular volumes and systolic function.

Summary
In this review article, we explore the principal pathophysiological mechanisms and pathways of heart failure in ischemic cardiomyopathy, therapeutic opportunities, and knowledge gaps in this area.
Clinical value and molecular mechanism of AQGPs in different tumors
Authors: Wang Rui , Wang Xuejian , Zhao Jun , Jin Jiacheng , Fan Weiwei , Zhu Xinqing , Chen Qiwei , Zhang Baochang , Lan Lan , Qu Kexin , Zhu Liang , Wang Jianbo 
Published: August 2022

AbstractAquaglyceroporins (AQGPs), including AQP3, AQP7, AQP9, and AQP10, are transmembrane channels that allow small solutes across biological membranes, such as water, glycerol, H2O2, and so on. Increasing evidence suggests that they play critical roles in cancer. Overexpression or knockdown of AQGPs can promote or inhibit cancer cell proliferation, migration, invasion, apoptosis, epithelial–mesenchymal transition and metastasis, and the expression levels of AQGPs are closely linked to the prognosis of cancer patients. Here, we provide a comprehensive and detailed review to discuss the expression patterns of AQGPs in different cancers as well as the relationship between the expression patterns and prognosis. Then, we elaborate the relevance between AQGPs and malignant behaviors in cancer as well as the latent upstream regulators and downstream targets or signaling pathways of AQGPs. Finally, we summarize the potential clinical value in cancer treatment. This review will provide us with new ideas and thoughts for subsequent cancer therapy specifically targeting AQGPs.
Regulation of the sensitivity of hepatocarcinoma cells by ORMDL3, to sorafenib by autophagy
Authors: Sun Yixiao , Guan Xueran , Zhang Ting , Li Yue , Shi Huiling , Chitakunye Ashleigh Tinotenda , Hong Hanyu , Zhang Shihui , Zhu Qin , Cai Lin 
Published: August 2022

AbstractSerum orosomucoid1-like protein 3 (ORMDL3) is a membrane protein in the endoplasmic reticulum, known to regulate many important signal transduction processes and autophagy regulation, but it is unclear whether it is involved in the intratumoral microenvironment and cancer drug resistance. Our present study found that silencing ORMDL3 increases the inhibitory effect of sorafenib on the viability and proliferation in HCC cells, and increases the sensitivity of HCC cells to sorafenib. In addition, silencing ORMDL3 can increase ROS levels by inhibiting autophagy, thereby increasing sorafenib-induced apoptosis of HCC cells. Further, our study also found that ORMDL3 silencing inhibits autophagy through the PERK-ATF4-Beclin1 pathway, thus affecting sorafenib sensitivity. The in vivo effects of sorafenib were tested by xenografting using nude mice. It showed that silencing ORMDL3 in HCC cells could increase the inhibitory effect of sorafenib on the growth of tumors. This is the first report to describe the relationships among ORMDL3, autophagy, and sorafenib resistance. This study provides available targets that might have a synergetic effect with sorafenib.
Health-Related Quality of Life, Fatigue, Level of Physical Activity, and Physical Capacity Before and After an Outpatient Rehabilitation Program for Women Within Working Age Treated for Breast Cancer
Authors: Gjerset Gunhild M. , Skaali Tone , Seland Mette , Thorsen Lene 
Published: August 2022

Abstract
The aims were to examine changes in patient-reported outcome measures (PROMs), level of physical activity (LPA), and physical capacity from before to after an outpatient rehabilitation program (ORP) for women with breast cancer (BC). Further aims were to explore the proportions of patients with clinically relevant improvements defined as ≥ 10% beneficial change in the scores of PROMs and variables associated with such improvements.A total of 270 women within working age (< 67 years) who recently (< 1.5 years) had completed primary therapy for BC with curative intent were included. The ORP consisted of seven weekly group sessions with patient education, group conversations, and PA. The patients completed questionnaires measuring health-related quality of life (HRQoL), fatigue and LPA before (T0), immediately after (T1), and 6 months after (T2) the program, and were physically tested at T0 and T1. The mean age of the patients was 50.4 years (SD 7.3) and the mean time since diagnosis was 10.6 months (SD 2.6). All patients had undergone surgery and 94% radiotherapy, and 96% had received chemotherapy and/or hormonal therapy.Physical-, role-, emotional-, cognitive-, and social function, global health, and fatigue significantly improved from T0 to T1. Physical-, role-, and cognitive function, and fatigue significantly improved from T1 to T2. LPA and physical capacity significantly improved from T0 to T1. More than 40% of the patients had a clinically relevant improvement in role-, social function, and fatigue symptoms, from T0 to T1. Low level of education was associated with an improvement in emotional function, and living alone was associated with an improvement in mental fatigue.HRQoL, fatigue, LPA, and physical capacity improved in women within working age recently treated for BC who participated in an ORP.
CIE-LSCP: color image encryption scheme based on the lifting scheme and cross-component permutation
Authors: Chen Xiuhui , Gong Mengxin , Gan Zhihua , Lu Yang , Chai Xiuli , He Xin 
Published: August 2022

AbstractEncryption of meaningful images into unidentifiable noise-like images can improve the security of images during storage and transmission. In this paper, a novel color image encryption method based on the lifting scheme and cross-component permutation (CIE-LSCP) is introduced. First, original image is divided into red, green and blue components, and then the three components are processed by a preprocessing strategy based on the lifting scheme (PSLS) to change the statistical distribution of the pixels. Second, a block-based cross-component permutation based on index vectors (BCPIV) is presented to divide three preprocessed components into blocks and perform the cross-component permutation operation on them, and three random matrices are utilized to determine the target component, target block and target pixel position of the current pixel to be moved, respectively. Subsequently, a multi stochastic diffusion based on random sequences (MSDRS) is developed to alter the pixel values of the permutated components, and finally a ciphertext image is gotten by merging the three components. Moreover, the SHA256 hash values of the plaintext image are used to obtain the initial parameters of the chaotic system, and the obtained chaotic sequences are applied in the image encryption process. Wherein the generated random sequences are highly reliant on the plaintext image, making the encryption scheme resistant to both known-plaintext attacks and chosen-plaintext attacks. Experimental results demonstrate that the proposed scheme has good security and effectiveness and can be applied for secure transmission of digital images over the Internet.
Structural scoliosis secondary to thoracic osteoid osteoma: a case report of delayed diagnosis
Authors: Zairi Mohamed , Nessib Mohamed Nabil 
Published: August 2022

Abstract
Purpose
The aim of this case report is to show that late diagnosis of vertebral osteoid osteoma gives rise to structural scoliosis which sometimes requires long-term management.

Methods
We report a case of an osteoid osteoma in the thoracic spine associated with structural scoliosis. We describe a 14-year-old boy who complained chronic nightly left back pain and scoliosis. Spine’s X-ray was reported thoraco-lumber scoliosis without bone lesion.

Results
MRI as well as technetium-99 m total body bone scan and a computed tomography scan revealed a bony lesion in the upper left joint of T11 vertebra consistent with the diagnosis of OO. Anatomopathological study of the resection piece confirmed the diagnosis of OO. Surgical excision of the tumor resolved pains, but scoliosis needed an orthopedic treatment for 1 year.

Conclusion
Through this case, it has been demonstrated that late diagnosed vertebral OO can be the cause of structural scoliosis. Clinical and radiological results indicate that OO resection is an effective and safe method of treatment.

Levels of evidence
IV.
Trouble neurocognitif majeur et méthodes optimisant l’apprentissage
Authors: Viscogliosi Chantal , Dame Nathalie , Mino-Roy Jordan , Rahimaly Sarah , Breton Viviane , Déry Jessica , Chassé Bernard , Couturier Yves , Giroux Dominique , Renaud Clémence , Provencher Véronique 
Published: August 2022

RésuméLes difficultés cognitives consécutives aux troubles neurocognitifs majeurs (TNCM) engendrent des enjeux dans la réalisation d’activités de la vie quotidienne. Ce projet visait à identifier auprès des proches aidants et des intervenants des situations nécessitant des méthodes optimisant l’apprentissage pour faciliter l’engagement de personnes vivant avec un TNCM dans leurs activités de la vie quotidienne. Des entrevues individuelles semi-dirigées, d’une durée de 60 à 90 minutes, ont été menées auprès de proches aidants et d’intervenants. Les résultats montrent que les activités quotidiennes et domestiques sont notamment affectées par les difficultés à repérer ou à utiliser les objets, à garder en tête la tâche en cours, à mettre en séquences des étapes, à ne pas se laisser distraire par autre chose et à constater ses difficultés pour s’y adapter. Les proches aidants souhaitent du soutien dans l’application des méthodes optimisant l’apprentissage pour contribuer au maintien de l’autonomie des personnes vivant avec un TNCM.
Chromothripsis is a frequent event and underlies typical genetic changes in early T-cell precursor lymphoblastic leukemia in adults
Authors: Arniani Silvia , Pierini Valentina , Pellanera Fabrizia , Matteucci Caterina , Di Giacomo Danika , Bardelli Valentina , Quintini Martina , Mavridou Elena , Lema Fernandez Anair Graciela , Nardelli Carlotta , Moretti Martina , Gorello Paolo , Crescenzi Barbara , Romoli Silvia , Beacci Donatella , Cerrano Marco , Fracchiolla Nicola , Sica Simona , Forghieri Fabio , Giglio Fabio , Dargenio Michela , Elia Loredana , La Starza Roberta , Mecucci Cristina 
Published: August 2022

AbstractChromothripsis is a mitotic catastrophe that arises from multiple double strand breaks and incorrect re-joining of one or a few chromosomes. We report on incidence, distribution, and features of chromothriptic events in T-cell acute lymphoblastic leukemias (T-ALL). SNP array was performed in 103 T-ALL (39 ETP/near ETP, 59 non-ETP, and 5 with unknown stage of differentiation), including 38 children and 65 adults. Chromothripsis was detected in 11.6% of all T-ALL and occurred only in adult cases with an immature phenotype (12/39 cases; 30%). It affected 1 to 4 chromosomes, and recurrently involved chromosomes 1, 6, 7, and 17. Abnormalities of genes typically associated with T-ALL were found at breakpoints of chromothripsis. In addition, it gave rise to new/rare alterations, such as, the SFPQ::ZFP36L2 fusion, reported in pediatric T-ALL, deletions of putative suppressors, such as IKZF2 and CSMD1, and amplification of the BCL2 gene. Compared to negative cases, chromothripsis positive T-ALL had a significantly higher level of MYCN expression, and a significant downregulation of RGCC, which is typically induced by TP53 in response to DNA damage. Furthermore we identified mutations and/or deletions of DNA repair/genome stability genes in all cases, and an association with NUP214 rearrangements in 33% of cases.
Expression profiles of respiratory V-ATPase and calprotectin in SARS-CoV-2 infection
Authors: Hou Yapeng , Wang Tingyu , Ding Yan , Yu Tong , Cui Yong , Nie Hongguang 
Published: August 2022

AbstractCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a pandemic threat that has been declared a public health emergency of international concern, whereas the effects of cellular microenvironment in the pathogenesis of SARS-CoV-2 are poorly understood. The detailed message of intracellular/lysosome pH was rarely concerned in SARS-CoV-2 infection, which was crucial for the cleavage of SARS-CoV-2 spike (S) protein. Calprotectin, an endogenous danger signal to activate inflammatory response, was vital for the proceeding of COVID-19. We found that the expressions of both vacuolar-ATPase (V-ATPase) and calprotectin (S100A8/S100A9) increased in SARS-CoV-2 infection, by analyzing single-cell RNA sequencing (bronchoalveolar lavage fluid), bulk-RNA sequencing (A549, lung tissue, NHBE), and proteomics (lung tissue), respectively. Furtherly, our wet experiments of flow cytometry and fluorescent assay identified that the intracellular and lysosome pH value was decreased after SARS-CoV-2 S plasmid transfection in A549 cells. Meanwhile, the enhancement of V-ATPase and calprotectin was verified by our real-time polymerase chain reaction and western blot experiment. Collectively, these data suggested that S protein increased V-ATPase in SARS-CoV-2 infection, which provided a microenvironment easier for the cleavage of S protein, and inflammatory cells were apt to be activated by the enhancement of calprotectin in respiratory epithelium. The comprehensive information on profiles of V-ATPase and calprotectin will make clearer about the involvement of cellular microenvironment in the pathogenesis of SARS-CoV-2, and provide a promising approach to combat COVID-19.
The addition of FAIMS increases targeted proteomics sensitivity from FFPE tumor biopsies
Authors: Sweet Steve , Chain David , Yu Wen , Martin Philip , Rebelatto Marlon , Chambers Andrew , Cecchi Fabiola , Kim Yeoun Jin 
Published: August 2022

AbstractMass spectrometry-based targeted proteomics allows objective protein quantitation of clinical biomarkers from a single section of formalin-fixed, paraffin-embedded (FFPE) tumor tissue biopsies. We combined high-field asymmetric waveform ion mobility spectrometry (FAIMS) and parallel reaction monitoring (PRM) to increase assay sensitivity. The modular nature of the FAIMS source allowed direct comparison of the performance of FAIMS-PRM to PRM. Limits of quantitation were determined by spiking synthetic peptides into a human spleen matrix. In addition, 20 clinical samples were analyzed using FAIMS-PRM and the quantitation of HER2 was compared with that obtained with the Ventana immunohistochemistry assay. FAIMS-PRM improved the overall signal-to-noise ratio over that from PRM and increased assay sensitivity in FFPE tissue analysis for four (HER2, EGFR, cMET, and KRAS) of five proteins of clinical interest. FAIMS-PRM enabled sensitive quantitation of basal HER2 expression in breast cancer samples classified as HER2 negative by immunohistochemistry. Furthermore, we determined the degree of FAIMS-dependent background reduction and showed that this correlated with an improved lower limit of quantitation with FAIMS. FAIMS-PRM is anticipated to benefit clinical trials in which multiple biomarker questions must be addressed and the availability of tumor biopsy samples is limited.