bluuebunny/crossref_metadata_2025_split huggingface dataset:
An automated multi-modal graph-based pipeline for mouse genetic discovery
Authors: Fang Zhuoqing , Peltz Gary 
Published: May 2022

AbstractMotivationOur ability to identify causative genetic factors for mouse genetic models of human diseases and biomedical traits has been limited by the difficulties associated with identifying true causative factors, which are often obscured by the many false positive genetic associations produced by a GWAS.ResultsTo accelerate the pace of genetic discovery, we developed a graph neural network (GNN)-based automated pipeline (GNNHap) that could rapidly analyze mouse genetic model data and identify high probability causal genetic factors for analyzed traits. After assessing the strength of allelic associations with the strain response pattern; this pipeline analyzes 29M published papers to assess candidate gene–phenotype relationships; and incorporates the information obtained from a protein–protein interaction network and protein sequence features into the analysis. The GNN model produces markedly improved results relative to that of a simple linear neural network. We demonstrate that GNNHap can identify novel causative genetic factors for murine models of diabetes/obesity and for cataract formation, which were validated by the phenotypes appearing in previously analyzed gene knockout mice. The diabetes/obesity results indicate how characterization of the underlying genetic architecture enables new therapies to be discovered and tested by applying ‘precision medicine’ principles to murine models.Availability and implementationThe GNNHap source code is freely available at https://github.com/zqfang/gnnhap, and the new version of the HBCGM program is available at https://github.com/zqfang/haplomap.Supplementary informationSupplementary data are available at Bioinformatics online.
An unexpected cause of a swollen pacemaker pocket: a case report
Authors: Popelier Bert , Vanheste Ruben , Cuypers Sofie , Heggermont Ward 
Published: May 2022

Abstract

Background
A complication originating from the pacemaker pocket after device implantation can most often be explained by a post-operative pocket haematoma, or, less frequently, by a pocket infection. Both conditions need immediate assessment, dedicated treatment, and specialized follow-up. In rare cases, however, a swollen pacemaker pocket has an alternative diagnosis, which is exemplified by the following case.

Case summary
A 70-year-old male patient had a-specific symptoms of fatigue, dyspnoea, and coughing for some weeks. He also noted an evident, new swelling of his pacemaker pocket several months after pacemaker implantation, a procedure that was performed in a high-volume center and without any complication. Ultrasound imaging of the pocket suggested the presence of a soft tissue mass with increased vascularity, rather than a fluid collection or a late organized haematoma. Ultrasound-guided biopsy of the mass was obtained for histopathology analysis and revealed a well-differentiated invasive squamous cell carcinoma. Additional PET-CT imaging demonstrated multiple fluorodeoxyglucose-avid hotspots: a voluminous lesion in the left lung hilum, smaller lesions in the liver, some mediastinal lymph nodes, several bone lesions, and a large mass surrounding the pacemaker. The multidisciplinary oncologic specialty team concluded that the patient had an aggressive metastatic lung carcinoma. The patient refused to undergo further treatment and died 1.5 months after diagnosis.

Discussion
To the best of our knowledge, we did not find any earlier reports of a squamous cell carcinoma of the lung spreading to a pacemaker pocket. Presentation of a primary tumour or a metastasis in a pacemaker pocket is extremely rare. Ultrasound imaging with ultrasound-guided biopsy is a fast and reliable method to sample the tissue and to obtain a reliable diagnosis.
Paroxysmal supine hypoxaemia with hyperthyroidism and atrial fibrillation: a case report of a diagnostic challenge
Authors: Liu Liang Yen , Reddy Yogesh N V , Niven Alexander S , Hu Tiffany Y , Larson Kathryn F , Mulpuru Siva K , Cullen Michael W 
Published: May 2022

Abstract

Background
A patent foramen ovale (PFO) is a persistent embryonic defect in the interatrial septum. Platypnoea-orthodeoxia syndrome is characterized by positional hypoxaemia that is most commonly due to right-to-left shunting through a PFO. Dynamic right-to-left shunting through a PFO can also exacerbate positional hypoxaemia without platypnea-orthodeoxia syndrome.

Case summary
A 78-year-old woman with hyperthyroidism and paroxysmal atrial fibrillation (AF) presented with positional hypoxaemia exacerbated by supine positioning. Diagnostic testing revealed intermittent right-to-left shunting through a PFO triggered by worsening atrial functional tricuspid regurgitation and elevated right atrial pressures. Diuresis, rate control, and thyroidectomy initially led to resolution of positional hypoxaemia, but recurrent AF episodes triggered right-to-left shunting with recurrent desaturation. Left atrial and cavo-tricuspid isthmus ablation led to restoration of normal sinus rhythm and resolution of positional hypoxaemia without PFO closure.

Discussion
The clinical presentation of intermittent intracardiac right-to-left shunting can mimic decompensated heart failure with pulmonary oedema. Persistent hypoxaemia out of proportion to the degree of pulmonary oedema and minimally responsive to supplemental O2 should raise suspicion for right-to-left shunt aetiology. Positional arterial blood gases can facilitate the diagnostic evaluation of refractory hypoxaemia in cases of suspected shunting. Diagnostic imaging for PFO detection includes both transthoracic and transesophageal echocardiography with Valsalva manoeuver and agitated saline injection. Closure of a PFO for management of arterial deoxygenation syndromes should not be performed before treating other causes of arterial deoxygenation and optimizing factors that may exacerbate shunting across the PFO.
Blue Rubber Bleb Nevus syndrome: case report from Syria
Authors: Haddad Joud , Salloum Riham , Omar Abdullah , Badran Ayham 
Published: May 2022

ABSTRACT
The rare syndrome of Blue Rubber Bleb Nevus is known to be causing skin vascular lesions in the form of bluish papules, called blue nevi and the movable rubber-like consistency soft tissue masses. The syndrome frequently involves digestive system besides other visceral organs such as liver, lungs, thyroid gland, spleen and nervous system. We present a case of a 36-year-old female with Blue Rubber Bleb Nevus that involved skin and musculoskeletal system.
Acute pyelonephritis revealing a rare renal collision tumor of papillary and chromophobe cell carcinoma with sarcomatoid features
Authors: Boukhannous Ibrahim , El Moudane Anouar , Mokhtari Mohamed , Chennoufi Mehdi , Miry Achref , Barki Ali 
Published: May 2022

ABSTRACT
A 59-year-old male patient was admitted to the emergency room with febrile right flank pain. The computed tomography scan and the magnetic resonance imaging had objectified lesion image occupying the upper half of the right kidney, measuring 82 mm, suggesting an infectious origin without excluding the infected tumor. He was put under antibiotics. A percutaneous biopsy revealed renal cell carcinoma with suppurative tumor necrosis. He underwent a right radical nephrectomy. The histopathological study revealed a collision tumor of papillary, chromophobe renal cell carcinoma and sarcomatoid dedifferentiation. It is the second case reported in English literature to date.
Practices, attitudes, and confidence related to tobacco treatment interventions in HIV clinics: a multisite cross-sectional survey
Authors: Bold Krysten W , Deng Yanhong , Dziura James , Porter Elizabeth , Sigel Keith M , Yager Jessica E , Ledgerwood David M , Bernstein Steven L , Edelman E Jennifer 
Published: May 2022

Abstract
Tobacco use disorder (TUD) is a major threat to health among people with HIV (PWH), but it is often untreated. Among HIV clinicians and staff, we sought to characterize practices, attitudes, and confidence addressing TUD among PWH to identify potential opportunities to enhance provision of care. Cross-sectional deidentified, web-based surveys were administered from November 4, 2020 through December 15, 2020 in HIV clinics in three health systems in the United States Northeast. Surveys assessed provider characteristics and experience, reported practices addressing tobacco use, and knowledge and attitudes regarding medications for TUD. Chi-square tests or Fisher’s exact tests were used to examine differences in responses between clinicians and staff who were prescribers versus nonprescribers and to examine factors associated with frequency of prescribing TUD medications. Among 118 survey respondents (56% prescribers), only 50% reported receiving prior training on brief smoking cessation interventions. Examining reported practices identified gaps in the delivery of TUD care, including counseling patients on the impact of smoking on HIV, knowledge of clinical practice guidelines, and implementation of assessment and brief interventions for smoking. Among prescribers, first-line medications for TUD were infrequently prescribed and concerns about medication side effects and interaction with antiretroviral treatments were associated with low frequency of prescribing. HIV clinicians and staff reported addressable gaps in their knowledge, understanding, and practices related to tobacco treatment. Additional work is needed to identify ways to ensure adequate training for providers to enhance the delivery of TUD treatment in HIV clinic settings.
A journey with TBM: into the third chapter
Authors: Knott Cheryl L 
Published: May 2022

Lay Summary
Research about health-related behaviors and health behavior change is most powerful when what is learned is applied to help real people in real-world settings. Our part of the field is concerned with finding ways to bring effective health-supporting strategies to reach the people that need them. This article talks about our journal and how we can reach people in diverse audiences with our research, for the greatest impact.
Research progress on train operation safety in Xinjiang railway under wind environment
Authors: Liu Tanghong , Wang Lei , Gao Hongrui , Xia Yutao , Guo Zijian , Li Wenhui , Liu Hongkang 
Published: May 2022

Abstract
Railway lines in the Xinjiang wind area face severe wind disasters year-round, which seriously affects the safety and economy of the railway in China. Therefore, the wind characteristics and statistics of wind-induced accidents along the Xinjiang railway lines are presented and the basic research route for evaluating the train running safety under crosswinds and effective measures to improve the windproof performances of trains are proposed, which are meaningful to deal with wind-induced train accidents. Based on this research route, a series of numerical simulations are conducted to evaluate train safety and the corresponding measures are provided. The results show the following. The running safety of the train under crosswinds mainly depends on the aerodynamic loads acting on the train. The relationships between the safe speed limit and train type, the load weight, the embankment height, the road cutting depth, the railway line curve parameters, the yaw angle and other factors are obtained. The critical wind-vehicle speed relationship, as well as the engineering speed limit value under different running conditions, are determined. Large values of the aerodynamic and dynamic indices mainly appear in special locations, such as near earth-embankment-type windbreak walls, shallow cuttings and the transition sections between various types of windbreak walls. Measures such as increasing the height of the earth-embankment-type windbreak walls, adding wind barriers with reasonable heights in shallow cuttings and optimizing the design of different types of transition sections are proposed to significantly improve the safe speed limits of trains under crosswinds.
Electrical Impedance Tomography in Acute Respiratory Distress Syndrome Management
Authors: Jimenez Jose Victor , Weirauch Andrew J. , Culter Christopher A. , Choi Philip J. , Hyzy Robert C. 
Published: May 2022

OBJECTIVE:
To describe, through a narrative review, the physiologic principles underlying electrical impedance tomography, and its potential applications in managing acute respiratory distress syndrome (ARDS). To address the current evidence supporting its use in different clinical scenarios along the ARDS management continuum.

DATA SOURCES:
We performed an online search in Pubmed to review articles. We searched MEDLINE, Cochrane Central Register, and clinicaltrials.gov for controlled trials databases.

STUDY SELECTION:
Selected publications included case series, pilot-physiologic studies, observational cohorts, and randomized controlled trials. To describe the rationale underlying physiologic principles, we included experimental studies.

DATA EXTRACTION:
Data from relevant publications were reviewed, analyzed, and its content summarized.

DATA SYNTHESIS:
Electrical impedance tomography is an imaging technique that has aided in understanding the mechanisms underlying multiple interventions used in ARDS management. It has the potential to monitor and predict the response to prone positioning, aid in the dosage of flow rate in high-flow nasal cannula, and guide the titration of positive-end expiratory pressure during invasive mechanical ventilation. The latter has been demonstrated to improve physiologic and mechanical parameters correlating with lung recruitment. Similarly, its use in detecting pneumothorax and harmful patient-ventilator interactions such as pendelluft has been proven effective. Nonetheless, its impact on clinically meaningful outcomes remains to be determined.

CONCLUSIONS:
Electrical impedance tomography is a potential tool for the individualized management of ARDS throughout its different stages. Clinical trials should aim to determine whether a specific approach can improve clinical outcomes in ARDS management.
Development and Implementation of an Oncology Clinical Research Nursing Residency Program for Newly Licensed Nurses
Authors: Legor Kristen A. , Caparrotta Caryn M. , Sze Cameron K. , Killion Leah J. , Gross Anne H. 
Published: May 2022

ABSTRACT
A paucity of nurses trained in clinical research prompted the development and implementation of a newly licensed nurse residency program in oncology research. The components of the program, funding, curriculum development, preceptor model, and partnerships, are described. Formal evaluation to quantify success in creating a pipeline for the future, increasing retention, and reducing costs is underway and will be reported in a future publication.
Six Steps in Reading to Appraise Scientific Publications
Authors: Pierce Linda L. , Gies Cheryl E. 
Published: May 2022

Abstract

Background
Effectively reading scientific publications, for example, research/quality improvement, is an acquired skill. Critical appraisal identifies articles’ strengths and weaknesses related to credibility and authenticity or appropriate standards.

Aim
To stimulate rehabilitation nurses’ interest/participation in reading to appraise published studies (using brief evaluation questions).

Steps Approach
Read in this order: (1) title, abstract, and key words (are these words clear and directly connected to identified problem?), (2) discussion and conclusion (how are results/findings interpreted; are there recommendations for actions?), (3) results/findings (do key outcomes relate to the problem?), (4) introduction and review of literature (what are main arguments for study/project; does the study build on what‘s already known?), (5) data collection and analysis methods (are materials/procedures described for gathering information and evaluation?), and (6) references (are citations accurate/up-to-date?).

Discussion/Relevance/Conclusion
Steps taken on this path help close the gap in reading to appraise scientific publications, discovering ways to build evidence-based rehabilitation nursing practices.
Differential impact of brain network efficiency on post-stroke motor and attentional deficits
Authors: Evangelista Giorgia G. , Egger Philip , Brügger Julia , Beanato Elena , Koch Philipp J. , Ceroni Martino , Fleury Lisa , Cadic-Melchior Andéol , Meyer Nathalie , de León Rodríguez Diego , Girard Gabriel , Léger Bertrand , Turlan Jean-Luc , Mühl Andreas , Vuadens Philippe , Adolphsen Jan , Jagella Caroline , Constantin Christophe , Alvarez Vincent , Ghika Joseph-André , San Millán Diego , Bonvin Christophe , Morishita Takuya , Wessel Maximilian J. , Van de Ville Dimitri , Hummel Friedhelm C. 
Published: May 2022

AbstractBackgroundMost studies on stroke have been designed to examine one deficit in isolation, yet survivors often have multiple deficits in different domains. While the mechanisms underlying multiple-domain deficits remain poorly understood, network-theoretical methods may open new avenues of understanding.Methods50 subacute stroke patients (7±3days post-stroke) underwent diffusion-weighted magnetic resonance imaging and a battery of clinical tests of motor and cognitive functions. We defined indices of impairment in strength, dexterity, and attention. We also computed imaging-based probabilistic tractography and whole brain connectomes. Overlaying individual lesion masks onto the tractograms enabled us to split the connectomes into their affected and unaffected parts and associate them to impairment.ResultsTo efficiently integrate inputs from different sources, brain networks rely on a “rich-club” of a few hub nodes. Lesions harm efficiency, particularly when they target the rich-club. We computed efficiency of the unaffected connectome, and found it was more strongly correlated to impairment in strength, dexterity and attention than efficiency of the total connectome. The magnitude of the correlation between efficiency and impairment followed the order attention > dexterity ≈ strength. Network weights associated with the rich-club were more strongly correlated to efficiency than non-rich-club weights.ConclusionsAttentional impairment is more sensitive to disruption of coordinated network activity between brain regions than motor impairment, which is sensitive to disruption of localized network activity. Providing more accurate reflections of actually functioning parts of the network enables the incorporation of information about the impact of brain lesions on connectomics contributing to a better understanding of underlying stroke mechanisms.
School principal's self-regulated learning: a conceptual framework of learning-centered leadership
Authors: Qadach Mowafaq , Schechter Chen , Da'as Rima'a 
Published: May 2022

PurposeThis study explores a conceptual framework that addresses a school principal's self-regulated learning (SPSRL) as well as possible avenues for future conceptualization of, and research into this issue.Design/methodology/approachThe conceptual framework of SPSRL is based on an extensive literature review of the research on student’s and teacher’s self-regulated learning models.FindingsA novel conceptual and practical SPSRL framework for planning, performing, monitoring and self-reflection is elaborated.Research limitations/implicationsThis novel SPSRL conceptual framework provides school principals with a means to shape and develop processes, strategies and structures to monitor and evaluate their learning, enabling them to react effectively in uncertain and dynamic environments. This framework may open the way to future research into possible contributions of the SPSRL construct with other variables related to principal effectiveness. The suggested framework should be examined empirically in various sociocultural contexts, possibly substantiating its conceptual validity.Originality/valueThe SPSRL conceptual framework can improve school learning, which might connect the individual (the school principal) and organizational (teachers) learning levels.
Required competencies for e-learning among science and mathematics supervisors: post-pandemic features of education
Authors: Alhashem Fatimah , Agha Nasser , Mohammad Anwar 
Published: May 2022

PurposeThe aim of this study was to measure the readiness of science and mathematics supervisors to utilize technology and online learning platforms for teachers' plans and professional development, during and after the period of the COVID-19 pandemic.Design/methodology/approachTo achieve this aim, the researchers developed a questionnaire comprising of 55 items based on the instruments used in pertinent studies. A mixed-methods research design was employed, whereby a quantitative online survey was supplemented by focus group discussions with selected supervisors. Survey data were subjected to one-way analysis of variance and t-test, while information obtained via focus groups was coded to identify common themes related to the obstacles and challenges supervisors face.FindingsWhen completing the survey, the supervisors approached proficiency using technology; however, focus group discussions revealed misconceptions related to e-leaning and limitations in their abilities to use technology in schools, as well as obstacles imposed by the structure and management of the educational system. TPractical implicationsThese findings indicate that supervisors need support in acquiring the competencies required for integrating technology in education, and that their support to teacher community needs to be grounded in clear and systematic approaches and best educational practices.Originality/valueThese findings indicate that supervisors need support in acquiring the competencies required for integrating technology in education, and that their support to teacher community needs to be grounded in clear and systematic approaches and best educational practices.
SIPOC-OI: a proposal for open innovation in supply chains
Authors: Assis de Souza Thais , Alcântara Pinto Guilherme , Rodrigues Antunes Luiz Guilherme , Grützmann André 
Published: May 2022

PurposeRegarding the premises of open innovation (OI) in terms of knowledge sources, this paper aims to discuss how to manage the existing sources of knowledge in supply chains.Design/methodology/approachAn integrative review was developed focusing on studies related to supply chain and OI, seeking to understand the relationships between them, supporting the innovative discussion.FindingsThe SIPOC-OI was proposed as a tool to support the management of knowledge sources present in the supply chain, promoting efficiency to the company and improving its innovative capacity.Research limitations/implicationsThe conceptual proposal should be empirically verified to understand the management tool's obstacles and benefits for a company's innovation performance. Additionally, it would be useful to understand the results of this proposal in the relationships between agents of the chain, as well as the direction (inbound, outbound or coupled). Additionally, relevant points were highlighted as future agendas.Practical implicationsThe point of view based on OI treats the collaboration's aspects and its benefits to agents, which becomes an essential factor in improving the entire chain's integration and performance.Originality/valueThe analysis of the flow of knowledge in supply chains from an OI perspective is an innovation in theory. Besides, the multidisciplinary proposal is expressed in the framework developed as it is based on a tool from engineering. Supply chain competencies/mindset is important to develop OI as well as is the contrary – there is a mutual practical and theoretical relevance between the integration of the concepts.