bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fertility-enhancing potential of ethanol extract of Cuscuta chinensis seeds in a rat model of unilateral cryptorchidism
Authors: Shu Jiao , Li Li , Yu Hui , Zhang Dandan 
Published: February 2022

Purpose: To investigate the fertility-enhancing potential of the ethanol extract of Cuscuta chinensis seeds in a rat model of unilateral cryptorchidism (ULC), and the mechanism(s) of action.
Methods: Healthy male Sprague Dawley rats (n = 48; mean weight = 220 ± 10 g) were randomly assigned to 4 groups (12 rats/group): control, ULC, 100 mg extract/kg and 200 mg extract/kg groups. Unilateral cryptorchidism of right testis was induced via standard method using an operating microscope. Rats in the treatment groups received 100 and 200 mg of ethanol extract of Cuscuta chinensis/kg orally once a day for 60 days. Sperm count and sperm motility were determined in seminal vesicular fluid (SVF) suspension. Oxidative stress markers and histological changes in rat testis were evaluated. The levels of caspase-3 and caspase-9 in testicular tissue were assessed by enzyme-linked immunosorbent assay (ELISA), while the protein expressions of Nrf2 and heme oxygenase 1 (HO-1) were determined using Western blotting.
Results: Body and reproductive organ weights, sperm count, sperm motility, and activities of glutathione peroxidase (GPx), catalase and superoxide dismutase (SOD) were significantly reduced in ULC group, relative to control group, but these parameters were significantly and dose-dependently increased following extract treatment (p < 0.05). Malondialdehyde (MDA), 8-hydroxy-2’-deoxyguanosine (8-OHdG), caspase-3 and caspase-9 levels were significantly higher in ULC group than in control group, but they were reduced significantly and dose-dependently after extract treatment (p < 0.05). Moreover, the protein expressions of Nrf2 and HO-1 were significantly downregulated in ULC group, when compared with control group, but they were significantly and dose-dependently upregulated by the extract (p < 0.05). Cross sections of testicular tissues of rats in ULC group revealed narrowed and thickened seminiferous tubules (disrupted spermatogonia) characterized by increased apoptotic bodies (increased number of necrotic Sertoli and Leydig cells). However, there were few damaged or necrotic Sertoli and Leydig cells, and complete absence of thickening of seminiferous tubules in testicular tissues of rats treated with the extract.
Conclusion: The ethanol extract of Cuscuta chinensis seeds effectively mitigates cryptorchidism in rats via mechanisms involving the regulation of Nrf2/HO-1 signaling pathway, and inhibition of apoptosis and oxidative stress. Thus, the plant extract has potentials for further development for the management of male infertility
Effect of fallopian tube dredging with a combination of hysteroscopy and Traditional Chinese medicine containing marine-derived principles in patients with inflammatory obstruction of fallopian tube
Authors: Li Meng-meng , Wang Wei-juan , Huang Feng , Wang Xiao 
Published: February 2022

Purpose: To investigate the therapeutic effect of fallopian tube dredging using a combination of hysteroscopy and Traditional Chinese Medicine (TCM) containing marine-derived bioactive principles on patients with inflammatory obstruction of fallopian tube.
Methods: A total of 108 patients with inflammatory obstruction of fallopian tube admitted to Weifang Maternal and Child Health Hospital from February 2017 to February 2018 were enrolled in the study. The patients were randomized into study group (n = 54) and reference group (n = 54). The reference group received traditional laparotomy, while the study group received fallopian tube dredging using hysteroscopy in combination with TCM containing marine-based bioactive principles. The clinical effects of the two treatments were compared.
Results: The number of completely unobstructed patients was significantly higher in the study group than in the reference group, with lower number of patients unilaterally unobstructed in the study group (p < 0.05). No significant differences in the number of bilaterally obstructed patients between the two groups were observed (p > 0.05). The study group showed an evidently higher total effectiveness rate than the reference group (p < 0.05). Stronger evidence of a higher number of cases of intrauterine pregnancy in the study group than that in the reference group was found, while a strikingly lower number of pregnancy failures and ectopic gestations in the study group was obtained, when compared to the reference group (p < 0.05).
Conclusion: Fallopian tube dredging combined with hysteroscopy and TCM containing marine-derived principles effectively improves treatment outcomes in patients with fallopian tube obstruction. Thus, the combination therapy has greater benefits than the traditional approach.
Analisis Faktor-Faktor yang Mempengaruhi Kinerja Karyawan di Bank Perkreditan Rakyat Kota Batam Dengan Kepuasan Kerja Sebagai Mediasi
Authors: Fatyandri Adi Neka , Ferdinand Ferdinand 
Published: February 2022

Employee performance is the work performance achieved by employees in the company. This means that the quality of work by an employee in carrying out the work given to him properly and correctly. Good employee performance can benefit the company in terms of operations and activities within the company. The research has done through distributing questionnaires to 130 respondents, in the form of google forms. The questionnaire contained questions related to the performance of employees at the rural bank in Batam city. The data that was collected, then tested using the PLS application. The test results concluded and found a significant positive relationship in some of the variables tested and there are also variables that have a significant negative relationship. The results of the study are expected to help researchers who research human resources and can be useful for the bank to determine the factors that can affect the performance of employees in the company.
ABSTRAK
Kinerja karyawan merupakan prestasi kerja yang dicapai pada suatu perusahaan. Artinya kualitas kerja seorang karyawam dalam melaksanakan pekerjaan yang diberikan kepadanya dengan baik dan benar. Kinerja karyawan yang baik dapat memberikan manfaat bagi perusahaan dalam hal operasional dan kegiatan di dalam perusahaan. Penelitian dilakukan melalui penyebaran kuesioner kepada 130 responden dalam bentuk google form. Kuesioner tersebut berisi pertanyaan-pertanyaan terkait kinerja karyawan pada BPR di kota Batam. Data yang terkumpul kemudian diuji menggunakan aplikasi PLS. Hasil pengujian menyimpulkan dan ditemukan hubungan positif yang signifikan pada beberapa variabel yang diuji dan terdapat juga variabel yang memiliki hubungan negatif yang signifikan. Hasil penelitian diharapkan dapat membantu peneliti yang meneliti pada bidang sumber daya manusia dan dapat bermanfaat bagi pihak bank untuk mengetahui faktor-faktor yang dapat mempengaruhi kinerja karyawan di perusahaan
Presepsi Baby Boomer Terhadap Persiapan Keuangan Memasuki Masa Pensiun Pada Karyawan Perbankan Di Kota Padang
Authors: Wijaya Riani Sukma , Nini Nini 
Published: February 2022

The aim of this study is to examine the perception of Baby Boomers in preparing their finances, financial planning and financial management for entering retirement. How they manage their finances with the management of family resources so. The analytical method used is qualitative analysis with the data analysis technique used is the waterfall model. Participants of the research was Convesioanal Bank employees in Padang City who are about to retire. Descriptive information about the sample was collected using a form containing personal data from the respondents and a list of questions to answer the research problem. Qualitatively, descriptive method is used to analyze data from respondents. The results of this study, respondents are more likely to invest their finances by buying stocks on the grounds that their finances are more secure and promise good returns. From a financial planning perspective, Baby Boomers plan their finances by saving some of their retirement money and the other half they will use for business activities by using consultant services to make their financial plans, and For financial management, some respondents are confused in managing their finances, because they do not know for sure What will their life be like in the future.
ABSTRAK
Tujuan dari penelitian ini untuk menguji presepsi Baby Boomer dalam mempersiapkan keuanganya, perancangan keuangan dan pengelolaan keuangan untuk memasuki masa pensiunan Bagaimana mereka mengatur keuangan mereka dengan adanya manajemen sumberdaya keluarga yang mana nantinya mereka dapat mengelola keuangannya dengan benar. Metode analisi yang digunakan yaitu analisis kulaitatif dengan teknik analisa data yang digunakan yaitu waterfall model. Partisipan dari penelitian karyawan Bank Convesioanal yang ada di Kota Padang yang akan memasuki masa pensiunan. Informasi secara deskriptif tentang sampel dikumpulkan dengan formulir yang berisi data pribadi dari responden dan daftar pertanyaan untuk menjawab permasalahan penelitian. Secara kualitatif, metode deskriptif di gunakam untuk menganalisa data dari responden. Hasil dari penelitian ini, responden lebih cendrung untuk menginvestasikan keuangan mereka dengan membeli saham dengan alasan keuangan mereka lebih aman dan menjanjikan retur yang baik, Dari sisi perencanaa keuangan Baby Boomer merencanakan keuangan mereka dengan menabung sebagian uang pensiunan dan setengahnya lagi akan mereka gunakan untuk kegitan usaha dengan mengunakan jasa konsultan untuk membuat perencanaan keuangan mereka, dan Untuk pengelolaan keuangan, sebagaian responden bingung dalam penglolaan keuangannya, karena mereka tidak mengetahui pasti kehidupan mereka seperti apa kedepannya.
Analisis Keakuratan Prediksi Financial Distress
Authors: Octavera Sari , Syafel Aristya 
Published: February 2022

This research is a descriptive research with a quantitative approach. The sampling technique used purposive sampling technique with 11 metal and similar sub-sector companies are listed on the Indonesia Stock Exchange (IDX) for the Q2 2018-Q2 2020 period as samples. The method used in this study is the Paired sample T test to see the differences between to the groups of models in predicting financial distress, and the result show that the Altman Z–Score-Zmijewski, Altman_Z_Score – Grover, Springate – Zmijewski, Grover – Zmijewski models have differences in predicting financial distress. Grover-Springate models has no differences predicting financial distress by looking at the Asymp value. Sig (2-tailed). Classify companies that experience financial distress and that do not experience financial distress as seen from the achievement of company profits that are positive categorized as companies that do not experience financial distress, and the other way companies that have negative profits are categorized as experiencing financial distress. Calculated the accuracy level of the model used in predicting financial distress and obtained the highest level of accuracy is owned by the Grover model with a value of 81.82% while the lowest level of accuracy is owned by the Altman Z-Score model with a value of 36.36%.
ABSTRAK
Penelitian ini merupakan penelitian deskriptif dengan pendekatan kuantitatif. Teknik penarikan sampel yang digunakan adalah teknik pusposive sampling, maka didapatkan 11 perusahaan subsektor logam dan sejenisnya yang terdaftar di Bursa Efek Indonesia (BEI) periode Q2 2018-Q2 2020 sebagai sampel. Metode yang digunakan dalam penelitian ini adalah Paired Sample T Test untuk melihat perbedaan antar dua kelompok model dalam memprediksi financial distress, dan didapatkan hasil bahwasanya model Altman Z–Score-Zmijewski, Altman_Z_Score – Grover, Springate – Zmijewski, Grover – Zmijewski memiliki perbedaan dalam memprediksi financial distress sementara model Grover – Springate tidak memiliki perbedaan dalam memprediksi financial distress dengan melihat nilai Asymp. Sig. (2-tailed). Pengklasifikasian perusahaan yang mengalami financial distress dan perusahaan yang tidak mengalami financial distress yang dilihat dari pencapaian laba perusahaan yang bernilai positif dikategorikan kepada perusahaan yang tidak mengalami financial distress, dan sebaliknya perusahaan yang memiliki laba negatif dikategorikan mengalami financial distress. Kemudian dilakukan perhitungan tingkat akurasi dari model yang digunakan dalam memprediksi financial distress dan didapatkan tingkat akurasi tertinggi dimiliki oleh model Grover dengan nilai 81,82% sedangkan tingkat akurasi yang terendah dimiliki oleh model Altman Z-Score dengan nilai 36,36%.
On the mode structure of imperfect fluids
Authors: Zimdahl Winfried 
Published: February 2022

This paper tries to present a simple picture of several aspects of the mode structure in relativistic non-equilibrium thermodynamics. Its pedagogical focus is on the relation between long-wavelength perturbation modes of the causal Müller-Israel-Stewart (MIS) theory and those of the traditional Eckart theory. Principally, this issue was clarified in a series of papers by Hiscock and Lindblom. Here, I put together some essential features of this topic which do not require the entire formalism of the complete theory.
CONFLICT POLICING IN THE PASTORAL COMMUNITIES IN ISIOLO COUNTY
Authors: Maelo Frederick , Harris Geoffrey 
Published: February 2022

Purpose: Isiolo is among north Eastern part of Kenya that has consistently experienced fatal conflicted clashes since 1990s. The effort to reduce these conflicts has remained unsustainable over years. Therefore, this study sought to assess the effectiveness of policing intervention in reducing armed violent conflict in Isiolo County.
Materials and Methods: This study was guided by two objectives seeking to assess effectiveness of policing interventions in reducing violent conflict in Isiolo boarder and investigate the factors for success or failure of policing intervention in address violent conflict in Isiolo. The study used content analysis research approach targeting, publication, police and security committee reports and secondary data from Armed Conflict Location and Event Data Project. Data was analysed using quantitative research approach.
Findings: The study found that the armed conflict/clashes in the region have not significantly reduced over the last three decade. The clashes are mainly caused by power struggle among the elites, weak social agreements; exclusion and marginalisation; Resource and environmental factors. The study concludes that use of conflict policing has low potential in reduction of crime in Isiolo region. The political interference, Kenya criminal justice, ethnic relations, Ethnic culture, corruption in the police sector and poor conditions and terms of service remain the major problem in the success of conflict policing in the region.
Recommendations: The study recommends integration of programmes such as economic empowerment, control of illegal firearm trade in the region, disarming program to reduce weapons from civilians, reconciliation program among communities involved and cracking down gang leaders. Also, good remuneration of police officers manning the area will improve service delivery in the region.
EDUCAÇÃ0 4.0:
Authors: Laryssa de Oliveira Agra Kamila 
Published: February 2022

Esse trabalho busca compreender as novas mudanças no mundo globalizado e como isso se dá dentro do sistema de educação, que traz consigo novas abordagens de ensino com o ensino híbrido e a escola invertida, que são propostas que fazem uso das tecnologias ativas em sua prática. Desse modo, os alunos são expostos a aulas mais dinâmicas e interativas onde são despertadas neles habilidades como a criatividade e o senso-crítico, nesse modelo o aluno torna-se protagonista ativo e aprende de forma significativa. Foi feita uma pesquisa quantitativa, de caráter exploratório, com orientação analítico-descritivo, mediante entrevistas semiestruturadas com questões abertas e fechadas. Os sujeitos são professores da rede pública e privada de ensino da cidade de Caruaru – PE. Os entrevistados consideraram que quando colocados diante de uma situação onde o uso de tecnologias ativas é exigido de forma integral, como foi o caso vivenciado nesse ano de 2020 devido ao COVID-19, isso ainda se dá de forma desafiadora, e que não receberam formação adequada nessa área, tendo que buscar por si só a capacitação. As medidas sugeridas para que isso venha ser melhorado é promover mais reflexão sobre o assunto “tecnologias ativas na prática escolar” , desenvolvendo ações de capacitação e formação específica em áreas tecnológicas , fazendo uso de novas modalidades de ensino, revendo os papéis dos docentes ,discentes, assim como a estrutura física das escolas que podem promover mais interação social, e da instituição escolar como um todo.
Trientine hydrochloride (MAR-Trientine)
Authors: Reimbursement Team  
Published: February 2022

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses trientine hydrochloride (MAR-Trientine) 250 mg capsules, oral.
Indication: For the treatment of patients with Wilson disease who are intolerant to penicillamine.
Spontaneous hematomas of the posterior cerebral fossa: about 5 cases
Authors: ELHAIRECH Dahmane , KANAZY Saloua , LMEJJATI Mohamed 
Published: February 2022

Spontaneous posterior fossa hematoma is defined as an intra-parenchymal hemorrhage that occurs suddenly following a spontaneous rupture of an artery or an arteriole. The objective of this work is to evaluate the prognosis of this pathology in our context compared to the data in the literature. Method and results: Our work is a retrospective study of 05 cases collected over a period of 4 years. The symptomatology for which the patients consulted varied: intracranial hypertension syndrome, neurological deficit. The positive diagnosis is made by cerebral CT scan and in view of the suspicion of a ruptured arteriovenous malformation, we recommended an arteriography in all patients but it was only performed in 2 patients. The surgical or abstentionist management was much discussed on a case-by-case basis. The outcome was favorable in 2 patients, 1 of whom had some neurological disorders. The study of data from the literature show that among the risk factors we find age, state of consciousness, the volume of the hematoma, ventricular flooding and whatever the therapeutic decision the extremely serious forms are always lethal.
Keywords: hematoma, posterior cerebral fossa arteriovenous malformation, surgery
The impact and causes of delayed diagnosis of epilepsy: experience of 3rd level hospital, Marrakech (Morocco)
Authors: BOUDANGA Assma , CHRAA Mohamed , CHAQDA Mustapha , Kissani Najib 
Published: February 2022

Epilepsy is a chronic neurological disease and one of the most common neurological disorders in the world, affecting approximately 69 million people worldwide. In Morocco, although epilepsy is treatable, about ¾ of epileptics do not receive treatment.
The objective of our study is to specify the frequency of the delay in the diagnosis of epilepsy among patients in Marrakech, and to clarify the reasons for this delay and its impact on the evolution of the disease.
Patients and methods: This is a retrospective study conducted on a sample of 152 patients from the neurology department at the CHU Mohammed VI of Marrakech from 2016 to 2019. We collected biographical data, clinical history, and age of first seizure, date of first consultation, use of maraboutic methods and outcome of patients.
Results: Of the 152 patients in this study, 72% were diagnosed late and were predominantly male. The age of the patients was between 18 and 39 years. The median time to diagnosis was 6 years. 15.3% of patients were diagnosed one year after the first attack, while 35% were diagnosed more than 6 years later. Half of our patients benefited from maraboutic methods.
Conclusion: Cultural and socio-economic status is an important factor in our study. Therefore, epilepsy is still considered a major public health problem that requires increased efforts.
Keywords: epilepsy, antiepileptic, treatment delay.
Guillain-Barré syndrome post Covid-19 vaccine: Two case reports
Authors: Benlamkadam S. , Zakaria Y. , Louhab N. , Kissani N. 
Published: February 2022

Introduction: Guillain-Barré syndrome is an acute polyradiculoneuropathy which is immune-mediated. It is potentially life-threatening due to respiratory involvement and dysautonomia. It is commonly reported as an adverse event after Campylobacter jejuni infection and following vaccination.
Methods: We report two cases of GBS occurring following reception of the first dose of the AstraZeneca COVID-19 vaccine.
Cases description: First case of a 70-year-old woman, presenting progressive, symmetric, ascending flaccid tetraparesis with bladder dysfunction which occurred three weeks after the first dose of AstraZeneca Covid-19 vaccine. The cerebrospinal fluid showed an albuminocytologic dissociation; electrophysiological studies showed an acute inflammatory demyelinating polyradiculoneuropathy. The second case was a 68-year-old woman, presenting three weeks after the first dose of the AstraZeneca Covid-19 vaccine, a progressively descending, symmetrical and synchronous tetraplegia, preceded 4 days before by diffuse headaches with involvement of multiple cranial pairs and bladder dysfunction. The cerebrospinal fluid showed an albuminocytologic dissociation, electrophysiological studies showed an acute inflammatory axonal and demyelinating polyradiculoneuropathy.
Conclusion: Many cases of GBS after vaccines have been reported including one case following the Pfizer Covid-19 vaccine, yet the pathophysiological mechanisms are not completely elucidated.
Keywords: Guillain-Barré syndrome, Adverse event, Covid-19 vaccine.
Ring chromosome 9 and chromosome 9p deletion associated with neurological and malformative syndrome
Authors: Bouzroud Wafaa , Ibenbrahim Youssra , Berrada Sarah , Maarouf Fatima , Tazzite Amal , Dehbi Hind 
Published: February 2022

Ring chromosome 9 is a rare chromosomal abnormality. The severity and nature of symptoms vary according to the structural abnormalities. Here, we report a case of a patient with neurological and malformative syndrome caused by a ring of chromosome 9 associated with partial 9p deletion. The 1-year-old child had a general hypotonia at birth regressed to peripheral hypotonia and normal axial tonus, psychomotor retardation, weight retardation, microcephaly and trigonocephaly, facial dysmorphia, flattened neck, abnormal nipple spread, dorsal kyphosis, white line hernia, ectopic testis and cardiac malformation cured at the age of 1 year, no other signs detectable. The standard constitutional karyotype revealed a ring of chromosome 9 with a deletion of the region pter-22p: 46,XY,r(9)(p22;q34). The chromosomal abnormality was homogeneous. The genetic counseling remains incomplete due to the absence of the parents’ karyotype. The cardinal traits reported in the ring chromosome 9 and chromosome 9p deletion syndrome were observed in our patient such as hypotonia, psychomotor retardation, microcephaly and trigonocephaly. Indeed, the deleted region contains numerous genes involved in the neurological manifestations and cranial dysmorphia including: CER1, FREM1, NFIB, GLDC, VLDLR, FOXD4, SMARCA2 and KANK1. Microarray analysis is important in order to detect the deleted segment and thereby the deleted genes.
The ring chromosome 9 is characterized by a genotype heterogeneity and a phenotype variability that can be due to multiple factors: loss or gain of genetic material, mitotic disruption, ring chromosome instability. Genotype-phenotype correlation could provide reliable information for genetic diagnosis, genetic counseling and clinical management.

Keywords: Chromosome 9, Ring, Deletion, Phenotype, Genotype.