bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between body mass index and incidence of breast cancer in premenopausal women: A Japanese nationwide database study
Authors: Konishi Takaaki , Fujiogi Michimasa , Michihata Nobuaki , Matsui Hiroki , Tanabe Masahiko , Seto Yasuyuki , Yasunaga Hideo 
Published: March 2022

Abstract
Purpose: The association between body mass index (BMI) and the incidence of premenopausal breast cancer in the Asian population remains unclear. We investigated this association using data from a Japanese nationwide administrative database.Methods: We retrospectively identified 785,703 females aged <45 years with available health checkup data on BMI from January 2005 and April 2020 from a Japanese nationwide database. Cox proportional hazards model was used to estimate hazard ratios for breast cancer (total breast cancer, breast cancer with hormonal drug and trastuzumab administration, and breast cancer by age ≤45 years) associated with BMI recorded at the first health checkup. We conducted restricted cubic spline analysis without BMI categorization to investigate potential nonlinear associations with adjustment for backgrounds such as smoking and alcohol consumption.Results: Overall, the median BMI was 20.5 (interquartile range [IQR], 18.9–22.7) kg/m2, and the median age was 37 (IQR, 29–41) years. Breast cancer occurred in 5597 participants (0.71%) at a median age of 44 (IQR, 42–46) years during a median follow-up of 1034 (IQR, 634–1779) days. A BMI of ≥22.0 kg/m2 was significantly associated with lower incidences of total breast cancer, breast cancer with hormonal drug administration, and breast cancer by age ≤45 years, whereas no significant associations were observed for breast cancer with trastuzumab administration. Conclusion: This study, which used a Japanese nationwide database, demonstrated that BMI was inversely associated with premenopausal breast cancer development in East Asian women, similar to that observed in Western women.
Effect of the External Shocks on the Predictability of Remittances flows from Developed Countries
Authors: KIMM GNANGNON SENA 
Published: March 2022

Abstract
The present analysis has explored the effect of external shocks on the predictability of remittances outflows, by relying on an unbalanced panel of 24 developed countries over the period of 1996–2020. Results are obtained from the use of the fixed effects estimator, and indicate that external shocks reduce the predictability of remittances outflows, with a higher effect on the positive predictability of these capital outflows than on the negative predictability of these capital outflows. The negative effect of external shocks on the predictability of remittances outflows operates through the economic growth channel, with the magnitude of this negative effect being higher in countries with low economic growth rates. External shocks enhance the predictability of remittances outflows in less developed countries among advanced economies, but reduce it in relatively more advanced economies. Finally, external shocks reduce the predictability of remittances outflows in countries that experience a decline in the migrants inflows. This finding has implications for the economic and development prospects of the countries of origin of migrants.
Evolving Norms: Social Media Data Analysis on Parks and Greenspaces Perception Changes Before and After COVID-19 Pandemic
Authors: Park Sohyun , Kim Seungman , Lee Jaehoon , Heo Biyoung 
Published: March 2022

Abstract
This study provides a novel approach to understand human perception changes in their experiences of and interactions with public greenspaces during the early months of COVID-19. Using social media data and machine learning techniques, the study delivers new understandings of how people began to feel differently about their experiences compared to pre-COVID times. The study illuminates a renewed appreciation of nature as well as an emerging but prominent pattern of emotional and spiritual experiences expressed through a social media platform. Given that most studies have almost exclusively examined whether park use increased or decreased during the pandemic, this research provides meaningful implications beyond the simple extensional visit pattern. It highlights the preeminent roles parks and greenspaces play during the pandemic and guides a new direction in future park development practice to support more natural elements and nature-oriented experiences from which emotional and spiritual well-being outcomes can be drawn.
Percutaneous microcoil localization of a small, totally endophytic renal mass for nephron-sparing surgery: A case report and literature review
Authors: Su Tianhao , Zhang Zhiyuan , Zhao Meishan , Hao Gangyue , Tian Ye , Jin Long 
Published: March 2022

Abstract
Background: Small, totally endophytic renal masses present a technical challenge for surgical extirpation due to poor identifiability during surgery. The method for the precise localization of totally endophytic tumours before nephron-sparing surgery could be optimized. Case presentation: An asymptomatic 70-year-old male presented with a right-sided, 16-mm, totally endophytic renal mass on computed tomography (CT). CT-guided percutaneous microcoil localization was carried out prior to laparoscopy to provide a direction for partial nephrectomy. During the 25 minutes of the localization procedure, the patient underwent five local CT scans, and his cumulative effective radiation dosage was 5.1 mSv. The span between localization and the start of the operation was 15 hours. The laparoscopic operation time was 105 minutes, and the ischaemia time was 25 minutes. The postoperative recovery was smooth, and no perioperative complications occurred. Pathology showed the mass to be renal clear cell carcinoma, WHO/ISUP grade 2, with a 2-mm, clear surgical margin. The patient remained free of recurrence on follow-up for eleven months. To our knowledge, this application of microcoil implantation prior to laparoscopic partial nephrectomy towards an intrarenal mass could be an early reported attempt for the localized method applied in renal surgery. Conclusions: The percutaneous microcoil localization of endophytic renal tumours is potentially safe and effective prior to laparoscopic partial nephrectomy.
Inorganic-organic Synergy in Nano-hybrids Makes a New Class of Drug
with Targeted Delivery: Glutamate Functionalization of Iron
Nanoparticles for Potential Bone Marrow Delivery and X-ray Dynamic
Therapy
Authors: Pal Samir Kumar , Ghosh Ria , Mondal Susmita , Mukherjee Dipanjan , Adhikari Aniruddha , Bhattacharyya Maitree 
Published: March 2022

Abstract:
The direct delivery of therapeutic molecules is generally inefficient and has several
problems. Hence, nanomedicines with targeted and controlled delivery applications have been an
exciting field of research for the past decade. In this regard, the adjustable properties of inorganic
nanoparticles like particle size distribution, ability to change the targeting ligand to have a higher
affinity towards the pathologic cell, and controlled delivery properties have made them indispensable
for targeted drug delivery applications. Changing the ligand on the surface of the inorganic nanoparticle
can direct different therapeutic molecules to different organs like the liver, spleen, kidney, bone, and
even brain. However, while the other targeted nanomedicines are well-reported, the targeting of
therapeutics to bone marrow cells is sparse in the literature. Hence, the administration of therapeutics
for bone-related disorders, like bone metastases, leads to several problems, such as severe systemic
toxicity and suboptimal efficacy. In this direction, we have shown our successful effort to functionalise
a model inorganic nanoparticle (Fe2O3) by glutamate ligand which is reported to have a high affinity
towards the NMDA receptors of the bone cells. We have performed spectroscopic studies to
characterize the nano-hybrid. We have shown that the cargo or the Fe2O3 nanoparticle possesses the
ability to generate photo-induced reactive oxygen species (ROS), thereby leading to a therapeutic
opportunity for bone metastases. In addition, the nanoparticle also possesses the ability to generate
enhanced ROS on X-ray irradiation, which may provide a new strategy for bone metastases and cancer
therapy. Also, this paper reviews the advancement in the drug delivery applications of inorganic
nanoparticles and highlights the crosstalk between the inorganic nanoparticles with the conjugated
targeting ligand for efficient delivery applications.
Dietary Acid Load Associated with Hypertension and Diabetes in the Elderly
Authors: Omma Tulay , Gulcelik Nese Ersoz , Zengin Fatmanur Humeyra , Karahan Irfan , Culha Cavit 
Published: March 2022

Background:
Diet can affect the body's acid-base balance due to its content of acid or
base precursors. There is conflicting evidence for the role of metabolic acidosis in the development
of cardiometabolic disorders, hypertension (HT), and insulin resistance (IR).

Objective:
We hypothesized that dietary acid load (DAL) is associated with adverse metabolic risk
factors and aimed to investigate this in the elderly.

Methods:
A total of 114 elderly participants were included in the study. The participants were divided into four groups such as HT, diabetes (DM), both HT and DM, and healthy controls. Anthropometric, biochemical, and clinical findings were recorded. Potential renal acid load (PRAL) and net endogenous acid production (NEAP) results were obtained from three-day, 24-hour dietary records via a nutrient database program. (BeBiS software program).

Results:
The groups were matched for age, gender, and BMI. There was a statistically significant
difference between the groups regarding NEAP (p =0.01) and no significant difference for PRAL (
p = 0.086). The lowest NEAP and PRAL levels were seen in the control group while the highest in
the HT group. Both NEAP and PRAL were correlated with waist circumference (r = 0,325, p =
0.001; r=0,231, p =0,016, respectively).

Conclusion:
Our data confirmed that subjects with HT and DM had diets with greater acid-forming
potential. High NEAP may be a risk factor for chronic metabolic diseases, particularly HT. PRAL
could not be shown as a significantly different marker in all participants. Dietary content has a significant
contribution to the reduction of cardiovascular risk factors, such as HT, DM, and obesity.
The Value of Tracking Data on the Behavior of Patients Who Have Undergone Bariatric Surgery: Explorative Study
Authors: Versteegden Dirk , van Himbeeck Magaly , Burghoorn Anne W , Lovei Peter , Deckers Eva , Jansen Jos-Marien , Nienhuijs Simon 
Published: March 2022

Background
To maintain the benefits of a bariatric procedure, patients have to change their lifestyle permanently. This happens within a context of coresponsibilities of health care professionals and their social support system. However, most interventions are focused on the patient as an individual. In this explorative pilot study, behavioral, contextual, and experiential data were gathered to obtain insight on coresponsibility.

Objective
The aim of this study is to explore the use of trackers by patients who have undergone bariatric surgery in a data-enabled design approach.

Methods
Behavioral and contextual data on the households of patients who have undergone bariatric surgery were explored using a smartphone with an interactive user interface (UI), weight scale, activity bracelet, smart socket, accelerometer motion sensor, and event button to find examples of opportunities for future interventions.

Results
A total of 6 households were monitored. Approximately 483,000 data points were collected, and the participants engaged in 1483 conversations with the system. Examples were found using different combinations of data types, which provided the obesity team a better understanding of patient behaviors and their support system, such as a referral to a family coach instead of a dietician. Another finding regarding the partners was, for example, that the conversational UI system facilitated discussion about the support structure by asking for awareness.

Conclusions
An intelligent system using a combination of quantitative data gathered by data tracking products in the home environment and qualitative data gathered by app-enhanced short conversations, as well as face-to-face interviews, is useful for an improved understanding of coresponsibilities in the households of patients who have undergone bariatric surgery. The examples found in this explorative study so far encourage research in this field.
Using Distance Communication for the User-Centered Development of a Smartphone-Based Serious Game for Children With Type 1 Diabetes: Participatory Design Approach
Authors: Nørlev Jannie , Derosche Christina , Sondrup Katrine , Hejlesen Ole , Hangaard Stine 
Published: March 2022

Background
The complications of type 1 diabetes (T1D) can be delayed or prevented in children with T1D who receive proper self-management education. Smartphone-based serious games are increasingly being used as an effective tool for teaching self-management. When developing a serious game, it is important that the development process be user-centered. Traditionally, different face-to-face methods have been used when children participate in the development process. However, face-to-face data collection is not always feasible. In such situations, distance communication can be used when developing a serious game.

Objective
The objective of this study is to develop a user-centered smartphone-based serious game that teaches self-management focused on carbohydrate intake in children aged 8-14 years with T1D using distance communication in both the development and evaluation of the game.

Methods
The development and evaluation of a smartphone-based serious game prototype was inspired by the Lean principles, and a user-centered approach was applied. The development process included 1 expert interview and design workshops with children with T1D. On the basis of the interview and design workshop results, a serious game prototype was developed using Microsoft PowerPoint. The evaluation of the serious game prototype included an interview with a dietitian and a playtest with children with T1D. All data were collected using distance communication.

Results
A user-centered smartphone-based serious game prototype was developed and evaluated. The expert interview with the dietitian formed the basis for the learning outcomes in the game. Four children and their parents contributed to the preferences, needs, requirements, and ideas for selected parts of the game design. The dietitian evaluated the prototype positively and validated its content and accuracy. The serious game prototype was well-received by the children and their parents during the playtest. The serious game prototype was perceived as a useful and engaging way to learn. However, the difficulty level was not appropriate, and the information was too basic for participants who had been diagnosed over a year ago. The use of digital communication platforms did not cause any problems.

Conclusions
The smartphone-based serious game prototype has the potential to be a useful and attractive tool for teaching disease self-management. The use of distance communication proved to be a useful approach in the development of a serious game.
Studi Network Congestion Dengan TCP Tahoe
Authors: Fajri Misbahul 
Published: March 2022

Perkembangan penggunaan komputer dan jaringan serta layanannya cepat berkembang dari masa ke masa, ini membuat kepadatan trafik data pada jaringan internet maupun intranet. Kemacetan jaringan internet pertama kali dialami pada akhir tahun 80-an dimana menurun drastis sehingga terjadi kolaps, kemudian pada tahun 1988 Jacobson mengusulkan teorinya yaitu Congestion Avoidance and Control. Congestion adalah pengumpulan paket melebihi kapasitas bandwidth yang tersedia pada link, congestion akan mengakibatkan penurun kinerja jaringan diantaranya; multiple packet losses, utilitas link yang rendah (low throughput), delay antrian yang tinggi, dan kemacetan yang parah (congestion collapse), ini menjadikan riset yang menantang untuk dipelajari dan dikembangkan, termaksud dalam penelitian ini. TCP Congestion Control adalah protokol TCP yang diterapkan pada end device yaitu di server dan client, protokol slow-start dan congestion avoidance serta Fast Retransmit merupakan awal dalam penelitian sebelumnya, topologi jaringan bottlenect yang dimana dimplementasikan mekanisme tersebut pada Transport Layer dengan trafik layanan FTP. Pada penelitian ini dilakukan studi lanjut dan analisa TCP Tahoe algortima, dimana mengimplementasikan keempat skenario standar sesuai mekanisme TCP. Simulasi penelitian ini menggunakan simulator OPNET dengan jaringan dumbbell dan paket discarding
Crypto Asset-Trade Resilience During The Covid-19 Pandemic In Indonesia
Authors: Taniady Vicko , Permatasari Salsabiila Puteri , Nugraha Reyka Widia 
Published: March 2022

Purpose of the study: This research aims to examine the resilience, existence, and security of crypto assets in Indonesia. In fact, bitcoin's presence results in pros and cons in society, so there is a need for a deeper study of crypto assets. Methodology: The research method used was normative-empirical law using a statutory approach and case studies. This research also employed literature study techniques to reveal theory, data, etc. Results: The results of this study indicated that the sustainability of crypto-asset trading in Indonesia has increased in demand even during the pandemic, and the public can perform trading activities safely because there are already several legal umbrellas related to crypto asset trading in Indonesia, which are regulated by Bappebti (Commodity Futures Trading Supervisory Agency). Applications of this study: This research is expected to provide literature related to crypto-asset regulation in Indonesia. On the other hand, the authors hope that this paper will be able to provide public awareness in conducting crypto-asset transactions in the form of bitcoin. Novelty/ Originality of this study: To obtain government protection in conducting crypto asset trading, customers need to choose crypto asset traders who have been registered and comply with the rules set by Bappebti. With the emergence of high risk in trading, the authors expect the costumers to be careful when choosing crypto asset traders.
Transparansi Pelaporan Dana Kampanye Dalam Mewujudkan Pemilu Yang Berintegritas
Authors: Neina Nailina Paramita , Azhari Aidul Fitriciada , Enggarani Nuria Siswi 
Published: March 2022

ABSTRACTObjective: This study aims to describe the transparency of the 2019 election campaign funds based on the laws and regulations and to find out in depth the legal consequences and sanctions received by election participants in reporting campaign funds.Methodology : The type of research used is empirical juridical, namely, examining everything related to legal provisions, as they have been implemented and how they were implemented in the broader community. The research sites are at the General Election Commission (Komisi Pemilihan Umum) office of Blora Regency, the Office of the Election Supervisory Board, and the Liaison Officer of the participating political parties. In this study, the solution to the problem lies in the transparency of reporting campaign funds for 2019 election participants, which researchers emphasize on the election participants for candidates for members of the Regional People's Representative Council of Blora Regency.Results : Transparency in Law Number 7 of 2017 concerning General Elections and General Election Commission Regulation Number 24 of 2018 as amended by General Election Commission Regulation Number 34 of 2018 concerning General Election Campaign Funds and Implementation of Campaign Fund Reporting for Election Contestants to Realize The 2019 election had been held at the Blora Regency General Election Commission. The General Election Commission of Blora Regency had implemented transparency in campaign finance reports in the 2019 Election. This can be seen from the regulations governing the Blora Regency General Election Commission's strategy in applying the principle of transparency regarding campaign finance reports in the 2019 Election in Blora Regency.Applications of this study: This study is expected to produce a formulation on campaign finance reporting that will be used by the General Elections Commission to develop policies and regulations on campaign finance reporting.. Novelty/ Originality of this study: Election results have had a significant impact on Indonesia's democratic order from year to year. If a regulation is properly implemented, it will have an impact on the general election process's pattern of continuity. The goal of this study was to talk about campaign finance transparency in the 2019 elections in Blora Regency..
Assessment of Exclusive Breast-Feeding Practice among HIV-Positive Mothers in Abuja Nigeria
Authors: Cajetan Ifeanyi Casmir Ifeanyichukwu , Aribike Janet , Ikeneche Nkiruka Florence , Ukwueze Lovina Nkechi , Iroegbu Gladys Adaku 
Published: March 2022

Background: Empirically, exclusive breastfeeding has proved invaluable in the reduction of mother-to-child transmission of human immunodeficiency virus and infant mortality particularly of children under-five years. Regrettably, breastfeeding practice is not widespread in most resource-poor sub-Saharan countries in Africa including Nigeria.
Objective: This study assessed the practice of exclusive breastfeeding of infants for the first-six months of life by HIV-positive mothers after receiving care for prevention of mother-to-child transmission.
Methods: Between February 2019 and September 2021, a cross-sectional descriptive study was conducted among 388 HIV-positive mothers receiving care for prevention of mother-to-child transmission of HIV at the Gwarinpa General Hospital in Abuja Municipal Area Council. HIV-positive mothers were enrolled and assessed for their practice of exclusive breastfeeding for the first-six months of the infant life. Structured questionnaires were used to survey for their socio-demographics, reproductive history, HIV and exclusive breastfeeding characteristics. Data were analyzed using Statistical Package for Social Science version SPSS 24.
Results: Overall, 68% of the HIV-positive mothers practiced exclusive breastfeeding for the first six months of life. Majority, 83% of the HIV-positive mothers had knowledge of the nutritional benefits of breast milk in the first-six months of infant’s life. In addition, 75% of them are aware that babies exclusively breastfed are healthier than those not so breastfed. Religious beliefs and education status positively influenced exclusive breastfeeding in 82% and 55% of the mothers respectively. However, 69% of HIV-positive mothers attest they had no communal norms and taboos against exclusive breastfeeding. In contrast, mothers’ occupation negatively influenced exclusive breastfeeding in 36% of the studied subjects.
Conclusion: This study found a significant increase in the rate of exclusive breastfeeding by HIV-positive mothers. It is evident that the practice of exclusive breastfeeding by HIV-positive mothers is dependent on their level of knowledge and awareness of its benefits in the first-six months of infant’s life.