bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smartphone‐based Electrochemical On‐site Quantitative Detection Device for Nonenzyme Lactate Detection
Authors: Zhang Xiaotao , Wei Yi , Wu Huihuang , Yan Hongli , Liu Yiming , Lučev Vasić Željka , Pan Haibo , Cifrek Mario , Du Min , Gao Yueming 
Published: January 2022

AbstractOn‐site quantitative detection provides the opportunity for accurate and timely health care, clinical diagnosis, environmental monitoring, and food analysis. A variety of portable electrochemical detection instruments have been developed at present for on‐site quantitative detection use, including commercially available portable potentiostats, but the reality is that these electrochemical detection devices still have the problem of narrow output voltage range and detection current range, and their performance of output voltage resolution and detection current resolution is still unsatisfactory. The narrow voltage or current range makes it difficult for some chemical reactions with peaks outside the range to proceed, and the insufficiency of voltage resolution and detection current resolution are key parameters restricting the detection accuracy of existing devices. In this regard, it is urgent to carry out partial transformation of the existing device to increase the use range and detection accuracy of the device. In the current work, a smartphone‐based electrochemical on‐site quantitative detection device was developed. The device comprises a portable small potentiostat, a smartphone equipped with a specially designed Android electrochemical detection application, and a disposable sensor (NiONP modified screen‐printed electrode [SPE]). The potentiostat can realize electrochemical detection methods, including cyclic voltammetry, chronoamperometry, and differential pulse voltammetry. In addition, the potentiostat can output a potential range −2.047∼+2.047 V with a current detection sensitivity scale 1×10−8∼1×10−3 A, and the current detection range could reach ±10 nA∼±10 mA. Most importantly, the current detection resolution of the potentiostat can reach 0.003 % (3.125 pA on ±10 nA range). The smartphone was used for communicating with the potentiostat, setting detection parameters, and mapping voltammograms in real time. The SPE was modified with nickel oxide nanoparticles and perfluorinated resin solution, which were employed as sensors to convert and amplify the electrochemical current response during the on‐site quantitative detection. Results indicated that the device features excellent performance for the lactate detection. The device covered a linear range 0.1∼30 mM on lactate detection with the correlation coefficient (R2) reaching 0.997.
Investigation of tropical plant‐based natural dyes combination and adsorption optimization for natural dye‐sensitized solar cell
Authors: Sullivan Hunter , Wang Bo , Jiang Lin 
Published: January 2022

AbstractDye‐sensitized solar cells (DSSC) are one low‐cost, easy fabrication solar cell with relatively high solar energy conversion efficiency that has been widely studied in the past decades. Environmentally friendly natural dyes are one of the most investigated candidates for the currently using ruthenium dyes; however, the efficiency is still low. In this study, three different tropical plants Calathea veitchiana (C), Begonia maculata (B) leaves, and Delonix regia (D) flowers were selected as dye sensitizers for TiO2 based DSSCs using the visible light absorption intensities and wavelength distributions. All the three plant extracts showed good solar energy conversion efficiency, and the C and D mixtures showed 24% more energy conversion efficiency promotion than that of the highest individual dyes. Our study also indicated that while the blend of natural plant extracts increased the short circuit current (Jsc) benefited from the broader visible light absorption, the complexity of the mixture could reduce the performance of the solar energy conversion rate by affecting the open‐circuit voltage (Voc). Our specially designed adsorption and desorption process using polarity different solvents significantly improved the conversion efficiency to as high as 1%. The final energy conversion rate is about 40% higher than that of the highest single plant extracts (0.72%). In summary, our study builds relatively high‐efficiency natural dye‐based DSSC using the combined extracts of two tropical plants with a concise screening process and provides a rapid approach to study the natural dye combinations in DSSCs studies.
Numerical simulation of a mechanical ventilation heat supply tower
Authors: Guo Haifeng , Zhou Shanshui , Zhang Zhao , Song Yanli , Shang Shaowen , Gao Xiangtao 
Published: January 2022

AbstractThis study put forward a scheme of heating the groundwater by using the heat supply tower (HST) when the temperature of the groundwater drops yearly. Fluent was used to conduct a 3‐D numerical simulation of heat and mass transfer between air and water in the tower. Taking the Shenyang area as an example, the influence of different air parameters was analyzed. When air velocity was 2.0 m/s and water flow velocity was 1.0 m/s, the heat supply performance was the best. When outdoor dry bulb temperature was 34°C, the contact heat transfer increased underground water temperature by 1.4°C. When wet bulb temperature of air was 23.7°C and the dew point temperature of water vapor was 20.0°C, the condensation heat transfer increased underground water temperature by 2.0  4.0°C. The total temperature rise of water in HST was 3.0 ~ 5.0°C when it was in contact with air, which can effectively alleviate the problem of groundwater temperature decrease. In this study, the static analysis method was used to analyze the economy of the tower and solar energy heat supplement. The conclusion was that the heating cost of the heating tower is lower.
High‐order isogeometric modified method of characteristics for two‐dimensional coupled Burgers' equations
Authors: Asmouh Ilham , El‐Amrani Mofdi , Seaid Mohammed , Yebari Naji 
Published: January 2022

AbstractThis paper presents a novel isogeometric modified method of characteristics for the numerical solution of the two‐dimensional nonlinear coupled Burgers' equations. The method combines the modified method of characteristics and the high‐order NURBS () elements to discretize the governing equations. The Lagrangian interpretation in this isogeometric analysis greatly reduces the time truncation errors in the Eulerian methods. A third‐order explicit Runge–Kutta scheme is used for the discretization in time. We present a detailed description of the algorithm used for the calculation of departure points and the interpolation stage. Our focus is on constructing highly accurate and stable solvers for the two‐dimensional nonlinear coupled Burgers' equations at high Reynolds numbers. A variety of benchmark tests and numerical examples are provided to show the effectiveness, accuracy, and performance of the proposed modified method of characteristics by virtue of potential advantages of isogeometric analysis. The method developed is anticipated to provide new research directions to the practical calculation of incompressible flows and to studies of their physical behavior.
Outcomes in surgical management of sinonasal malignancy—A single comprehensive cancer center experience
Authors: Adilbay Dauren , Valero Cristina , Fitzgerald Conall , Yuan Avery , Mimica Ximena , Gupta Piyush , Wong Richard J. , Shah Jatin P. , Patel Snehal G. , Ganly Ian , Cohen Marc A. 
Published: January 2022

AbstractBackgroundSinonasal malignancies are a complex and diverse group of tumors. Over the past five decades, treatment advances have changed the management paradigms for these tumors. Our aim was to analyze the outcomes of patients from a comprehensive cancer center.Materials and MethodsWe retrospectively assessed 400 patients with sinonasal malignancies treated with surgery at our center between 1973 and 2015. Multiple variables were reviewed to assess the influence on 5‐year outcomes.ResultsThe median age was 56 years (IQR 46.8–68). Two hundred and fifty‐nine (65%) were males and 141 (35%) were females. Overall survival (OS) and disease‐specific survival (DSS) improved in the last analyzed decade. Orbital invasion, advanced pT‐classification and pN‐classification, and melanoma histology were associated with poorer outcomes.ConclusionTreatment outcomes for patients with sinonasal malignancy have improved over time. This is likely multifactorial with advances in surgical technique, adjuvant treatment, and patient selection. pT‐classification, pN‐classification, orbital invasion, and histology are predictive of survival.
Cancer‐associated fibroblasts at the unfavorable desmoplastic stroma promote colorectal cancer aggressiveness: Potential role of ADAM9
Authors: Ao Tadakazu , Mochizuki Satsuki , Kajiwara Yoshiki , Yonemura Keisuke , Shiraishi Takehiro , Nagata Ken , Shinto Eiji , Okamoto Koichi , Nearchou Ines P. , Shimazaki Hideyuki , Kishi Yoji , Okada Yasunori , Ueno Hideki 
Published: January 2022

AbstractThe tumor microenvironment plays a key role in cancer aggressiveness. Desmoplastic reaction (DR), morphologically classified as Mature, Intermediate and Immature types, has previously been shown to be highly prognostic in colorectal cancer (CRC) and it consists to a large extent of cancer‐associated fibroblasts (CAFs). The aim of our study was to characterize the molecular background of DR and understand the effects of CAFs in tumor aggressiveness. The prognostic significance of DR was initially examined in 1497 patients. Then CAFs originating from patient tissues with different DR types were isolated and their impact on tumor growth was examined both in vitro and in vivo. DR was shown to be highly prognostic, with patients within the Immature DR group conferring the worst relapse‐free survival. The conditioned media of CAFs from tumor with Immature‐type DR (CAFsImmature) significantly increased proliferation and migration of CRC cell lines and growth of CRC‐derived organoids compared to that of CAFs from Mature‐type DR (CAFsMature). Subcutaneous or orthotopic implantation of CRC cells together with CAFsImmature in mice significantly promoted tumor growth and dissemination compared to implantation with CAFsMature. Systematic examination of the expression of “a disintegrin and metalloproteinases” (ADAMs) in CAFs isolated from CRC tissues showed that the secreted isoform of ADAM9 (ADAM9s) was significantly higher in CAFsImmature than in CAFsMature. Knockdown of ADAM9s in CAFsImmature abrogated the promoting effects on CRC cell proliferation and migration. CAFs‐derived ADAM9s is implicated in deteriorating survival in CRC patients with Immature‐type DR by increasing tumor cell proliferation and dissemination.
Robot‐assisted radical nephrectomy and inferior vena cava tumor thrombectomy: Initial experience in Japan
Authors: Motoyama Daisuke , Ito Toshiki , Sugiyama Takayuki , Otsuka Atsushi , Miyake Hideaki 
Published: January 2022

IntroductionOpen surgical approach remains the standard treatment for renal cell carcinoma with an inferior vena cava tumor thrombus. In recent years, however, robot‐assisted radical nephrectomy and inferior vena cava tumor thrombectomy have emerged as minimally invasive alternatives to conventional open surgery.Case presentationHere, we describe a 76‐year‐old female patient with right renal cell carcinoma with a level I inferior vena cava thrombus undergoing robot‐assisted radical nephrectomy and inferior vena cava tumor thrombectomy, which was successfully completed with a purely robotic procedure, resulting in the following outcomes: console time,167 min; total operative time, 211 min; and estimated blood loss, 150 mL. To our knowledge, this is the first case managed by robot‐assisted radical nephrectomy and inferior vena cava tumor thrombectomy in Japan.ConclusionBased on our experience, it might be worthwhile to consider purely robotic surgery for the treatment of renal cell carcinoma with an inferior vena cava thrombus.
Exposure to aerosolized staphylococcal enterotoxin B potentiated by lipopolysaccharide modifies lung transcriptomes and results in lung injury in the mouse model
Authors: Zong Fuliang , Gan Changjiao , Wang Yifeng , Su Duo , Deng Mengyun , Xiao Nan , Zhang Zhipeng , Zhou Dongsheng , Gao Bo , Yang Huiying 
Published: January 2022

AbstractLipopolysaccharide (LPS) is one of the main constituents of the cell wall in Gram‐negative bacteria. Staphylococcal enterotoxin B (SEB) is produced by the Gram‐positive opportunistic pathogen, Staphylococcus aureus. Emerging evidence suggests that intraperitoneal injection of LPS combined with low‐dose aerosolized SEB exposure can cause severe lung injury and even death, while SEB or LPS alone cause neither mortality nor severe pulmonary symptoms in mice. However, pulmonary effects from exposure to aerosolized SEB potentiated by LPS have not been evaluated. This study investigates the global transcriptome profile of lung tissue in mice after exposure to aerosolized SEB potentiated by LPS or LPS alone. A mouse model of intratracheal exposure to LPS‐potentiated aerosolized SEB is established and described through histological examination. Transcriptome analysis revealed LPS‐potentiated aerosolized SEB affected mouse lungs within 72 h post‐SEB inhalation, gradually causing lung injury starting from 24 h post inhalation. Hub genes leading to lung injury at 48 h post inhalation have been identified. Flow cytometry revealed that LPS potentiation of low‐dose SEB produces a superantigen response that T cells expressing a particular T cell receptor Vβ induces a proliferation response by 72 h post inhalation in the lungs of mice. This study represents the first research to investigate pulmonary transcriptional responses of LPS‐potentiated aerosolized low‐dose SEB exposure. This research helps to elucidate the molecular mechanisms underlying the process by which the two bacterial components combined to produce lung damage and provides an insight into potential treatments for alleviating inflammation of the lung when coinfection is present.
Dynamic development of the extracellular matrix in chick cornea
Authors: Chen Yang‐Fang , Dong Chen‐Yuan 
Published: January 2022

AbstractUnderstanding the mechanisms of structural organization of corneal stroma is scientifically interesting and may lead to advances in corneal tissue engineering. In the past, we used the combination of second harmonic generation and fast Fourier transform to study a number of topics including the structural alteration of human keratoconus. Recently, we applied this approach to studying changes of chick embryonic cornea during development. As numerous studies were performed with ex vivo specimens, a thorough understanding of the parameters associated with the development process cannot be achieved until experiments are performed in living chick embryos.
Population‐based cohort imaging: skeletal muscle mass by magnetic resonance imaging in correlation to bioelectrical‐impedance analysis
Authors: Kiefer Lena S. , Fabian Jana , Rospleszcz Susanne , Lorbeer Roberto , Machann Jürgen , Kraus Mareen S. , Fischer Marc , Roemer Frank , Rathmann Wolfgang , Meisinger Christa , Heier Margit , Nikolaou Konstantin , Peters Annette , Storz Corinna , Schlett Christopher L. , Bamberg Fabian 
Published: January 2022

AbstractBackgroundSkeletal muscle mass is subjected to constant changes and is considered a good predictor for outcome in various diseases. Bioelectrical‐impedance analysis (BIA) and magnetic resonance imaging (MRI) are approved methodologies for its assessment. However, muscle mass estimations by BIA may be influenced by excess intramuscular lipids and adipose tissue in obesity. The objective of this study was to evaluate the feasibility of quantitative assessment of skeletal muscle mass by MRI as compared with BIA.MethodsSubjects from a population‐based cohort underwent BIA (50 kHz, 0.8 mA) and whole‐body MRI including chemical‐shift encoded MRI (six echo times). Abdominal muscle mass by MRI was quantified as total and fat‐free cross‐sectional area by a standardized manual segmentation‐algorithm and normalized to subjects' body height2 (abdominal muscle mass indices: AMMIMRI).ResultsAmong 335 included subjects (56.3 ± 9.1 years, 56.1% male), 95 (28.4%) were obese (BMI ≥ 30 kg/m2). MRI‐based and BIA‐based measures of muscle mass were strongly correlated, particularly in non‐obese subjects [r < 0.74 in non‐obese (P < 0.001) vs. r < 0.56 in obese (P < 0.001)]. Median AMMITotal(MRI) was significantly higher in obese as compared with non‐obese subjects (3246.7 ± 606.1 mm2/m2 vs. 2839.0 ± 535.8 mm2/m2, P < 0.001, respectively), whereas the ratio AMMIFat‐free/AMMITotal (by MRI) was significantly higher in non‐obese individuals (59.3 ± 10.1% vs. 53.5 ± 10.6%, P < 0.001, respectively). No significant difference was found regarding AMMIFat‐free(MRI) (P = 0.424). In analyses adjusted for age and sex, impaired glucose tolerance and measures of obesity were significantly and positively associated with AMMITotal(MRI) and significantly and inversely with the ratio AMMIFat‐free(MRI)/AMMITotal(MRI) (P < 0.001).ConclusionsMRI‐based assessment of muscle mass is feasible in population‐based imaging and strongly correlated with BIA. However, the observed weaker correlation in obese subjects may explain the known limitation of BIA in obesity and promote MRI‐based assessments. Thus, skeletal muscle mass parameters by MRI may serve as practical imaging biomarkers independent of subjects' body weight.
The mouse at the popcorn stage of development
Authors: Lalonde Robert , Strazielle Catherine 
Published: January 2022

AbstractIn mice, rats, and rabbits, vigorous jumping and hyperexcitability occur at the popcorn stage of postnatal development. In view of subcortical structures appearing before cortical ones, the trait is deemed to occur at the maturation time of ascending excitatory projections from the brainstem and to disappear at the maturation time of descending inhibitory projections from the forebrain. There is evidence that the popcorn stage may be due in part to the lack of a cholinergic influence on dopamine systems. Based mostly on results found in adult mice and rats, there may also be a role for cortico‐subcortical systems that include the cerebellum and basal ganglia requiring the influence of biogenic amines, glutamate, and endocannabinoids.
Model‐based dynamic off‐resonance correction for improved accelerated fMRI in awake behaving nonhuman primates
Authors: Shahdloo Mo , Schüffelgen Urs , Papp Daniel , Miller Karla L. , Chiew Mark 
Published: January 2022

PurposeTo estimate dynamic off‐resonance due to vigorous body motion in accelerated fMRI of awake behaving nonhuman primates (NHPs) using the echo‐planar imaging reference navigator, in order to attenuate the effects of time‐varying off‐resonance on the reconstruction.MethodsIn NHP fMRI, the animal’s head is usually head‐posted, and the dynamic off‐resonance is mainly caused by motion in body parts that are distant from the brain and have low spatial frequency. Hence, off‐resonance at each frame can be approximated as a spatially linear perturbation of the off‐resonance at a reference frame, and is manifested as a relative linear shift in k‐space. Using GRAPPA operators, we estimated these shifts by comparing the navigator at each time frame with that at the reference frame. Estimated shifts were then used to correct the data at each frame. The proposed method was evaluated in phantom scans, simulations, and in vivo data.ResultsThe proposed method is shown to successfully estimate spatially low‐order dynamic off‐resonance perturbations, including induced linear off‐resonance perturbations in phantoms, and is able to correct retrospectively corrupted data in simulations. Finally, it is shown to reduce ghosting artifacts and geometric distortions by up to 20% in simultaneous multislice in vivo acquisitions in awake‐behaving NHPs.ConclusionA method is proposed that does not need sequence modification or extra acquisitions and makes accelerated awake behaving NHP imaging more robust and reliable, reducing the gap between what is possible with NHP protocols and state‐of‐the‐art human imaging.
District nursing and family/whanau assessment practices: A New Zealand study
Authors: Richardson Anna , Richardson Sandra , McAllum Alex 
Published: January 2022

AbstractAimDistrict Nurses apply specialized nursing knowledge and assessment skills to provide care in New Zealand communities. This study aimed to identify whether District Nurse's (both Registered and supervised Enrolled Nurse's) had knowledge of, and used the 15‐Minute Interview tool, including Ecomaps/Genograms, and if not, what they saw as enablers or barriers to doing so.DesignParticipatory action research was used, following the phases of look, think and act.MethodsTwo pre‐intervention focus groups occurred, two education sessions which introduced the 15‐Minute Interview and four postintervention interviews which explored the use of the tools and their potential use in the future.ResultsDistrict Nurses demonstrated working with families, and the selection of when and where to apply the 15‐Minute Interview.
Effects of probiotics on cognitive and emotional functions in healthy older adults: Protocol for a double‐blind randomized placebo‐controlled crossover trial
Authors: Ruiz‐Gonzalez Cristofer , Cardona Diana , Rodriguez‐Arrastia Miguel , Ropero‐Padilla Carmen , Rueda‐Ruzafa Lola , Carvajal Francisca , Sanchez‐Labraca Nuria , Aparicio Mota Adrian , Roman Pablo 
Published: January 2022

AbstractAging is a process that includes changes in cognitive and emotional functions, as well as changes in the diversity and integrity of gut microbiota. Probiotic treatments have recently been studied as a potential new therapeutic approach to alleviate a wide range of problems in other populations; however, clinical studies in older adults remain insufficient and limited. Thus, the aim of this project is to evaluate the efficacy of a multispecies probiotic formulation as a therapeutic strategy for attenuating the emotional and cognitive decline associated with aging in adults over the age of 55. This is a double‐blind randomized placebo‐controlled crossover trial involving at least 32 older adults and comparing two conditions: (a) probiotic, providing a multispecies probiotic for 10 weeks (Lactobacillus rhamnosus and Bifidobacterium lactis); and (b) placebo, receiving a harmless substance (potato starch). Despite the increasing use of probiotics for the treatment of cognitive and emotional problems, no study has yet focused on this group, to the best of our knowledge. Therapeutic strategies of the kind outlined in this protocol will help to shed light on the current state of knowledge about this topic, as well as promote health programs tailored to this population, which would encourage active aging and healthy lifestyles. Not only do we expect improvements in the emotional dimension in terms of anxiety, stress, depression, and sleep quality, we also expect improvements in the cognitive dimension in terms of attention, memory, and decreased impulsivity.
Normative fundraising ethics: A review of the field
Authors: MacQuillin Ian 
Published: January 2022

AbstractThe ethics of fundraising has received scant attention in the academic literature, while there is not a huge amount in the grey and practitioner literature either. There is little that explicitly describes normative theories of fundraising—broad concepts of how fundraising ought to be practised, from which recommendions for applied ethical practice can be drawn. This is the first review of the literature on fundraising ethics, articulating, synthesing and naming (often for the first time) 14 ethical theories/lenses that can be inferred (few are explicitly stated as normative ethical theories) from the literature. In so doing, this review provides scholars and practitioners with a much firmer conceptual foundation for examining and developing professional fundraising ethics, and for analysing applied practice and finding solutions to the ethical dilemmas in applied practice.