bluuebunny/crossref_metadata_2025_split huggingface dataset:
Field Pigging Modeling for Predicting Wax Breaking Force and Wax Removal Efficiency of Disk Pig
Authors: Zhang Xun , Huang Qiyu , Chen Wei , Zhang Yu , Gao Xuedong , Liu Yamei , Wang Yijie 
Published: May 2022

Summary
Pigging technology is the most common and cost-effective method for wax deposition remediation, but the inability to accurately predict the pigging parameters during the field pigging process causes pipe plugging incidents to occur from time to time. This study developed a theoretical model that incorporates the rheomalaxis elastoviscoplasticity (REVP) of the wax deposit. The concepts of dynamic and static yield stresses were introduced to determine the maximum shear stress in two shear states. The proposed model can accurately estimate the wax breaking force (WBF) and the wax removal efficiency (WRE) under various pigging conditions, according to the experimental results and published data. In addition, the indoor pigging experiments revealed for the first time that a higher pigging speed could increase the WBF while reducing the WRE of the disk pig. The model interpreted these experimental results as a consequence of the rheological behavior of the wax deposit (i.e., the increase in the ramp rate of the shear rate leads to higher dynamic yield stress).
Implication of miR-155-5p and miR-143-3p in the vascular insulin resistance and instability of human and experimental atherosclerotic plaque
Authors: González-López Paula , Ares-Carral Carla , López-Pastor Andrea R. , Infante-Menéndez Jorge , Gonzalez-Illanes Tamara , Céniga Melina Vega , Esparza Leticia , Beneit Nuria , Martín-Ventura José Luis , Escribano Óscar , Gómez-Hernández Almudena 
Published: May 2022

Abstract
Background: Cardiovascular diseases (CVDs) are the main cause of death in first world countries, being atherosclerosis, a recurring process underlying their apparition. MicroRNAs (miRNAs) are small non-coding RNAs that modulate the expression of their target proteins. Therefore, they have emerged as key players in diseases like cancer, diabetes, or CVDs. Methods: Apolipoprotein E-deficient (ApoE-/-) mice fed a standard type diet (STD) or high fat diet (HFD) for 8 and 18 weeks was compared to wild type (WT) STD-fed groups for the same time. 18 miRNAs were selected (from Pubmed and GEO database) for their possible role in promoting atherosclerosis and were analysed by RT-qPCR in the aorta from the experimental model. Afterwards, the altered miRNAs in the aorta from 18 weeks-ApoE-/- mice were studied in human healthy aortic samples, human early aortic atherosclerotic plaques, and human advanced carotid atherosclerotic plaques. Results: From the 18 miRNAs analyzed, miR-155-5p was overexpressed and miR-143-3p was downregulated in mouse and human atherosclerotic lesions. In addition, a significant decrease of protein kinase B (AKT), target of miR-155-5p, and an increase of insulin-like growth factor type II receptor (IGF-IIR), target of miR-143-3p, were noted in aortic roots from ApoE-/- mice and in carotid plaques from ACA patients. Finally, both miRNAs were studied on vascular endothelial and smooth muscle cell lines. The overexpression of miR-155-5p reduced AKT levels and its phosphorylation in vascular smooth muscle cells. MiR-143-3p overexpression decreased IGF-IIR reducing apoptosis in vascular cells. Conclusions: Our results suggest that miR-155-5p and miR-143-3p may be implicated in insulin resistance and plaque instability by the modulation of their targets AKT and IGF-IIR, contributing to the progression of experimental and human atherosclerosis.Trial Registration: authorization numbers PFS09-007 and PI1442016.
Clinical Observation of Comparing the Efficacy of Three-drug Regimens Containing Olanzapine/Dexamethasone in Preventing Hyperemetic Chemotherapy-induced Nausea and Vomiting (CINV)
Authors: Zhang Min , Zhang Xiaodi , Liu Ding , Bai Bin , Shen Wei , Meng Xiangli , Gao yanxin , Liu Yanting , Qin Shuang , Lu Ping 
Published: May 2022

Abstract
A randomized, open-label, parallel-controlled study was conducted to compare the efficacy of two kind of three-drug Regimens containing olanzapine/dexamethasone for the prevention of CINV induced by hyperemetic chemotherapy. The results showed that there was no significant difference in the complete response rates of nausea and vomiting between the two groups. However, the anxiety, depression and sleep quality of the patients in the olanzapine group were improved. It was concluded that the three-drug antiemetic regimen of "olanzapine +palonosetron+fosaprepitant" could effectively prevent CINV caused by hyperemetic chemotherapy, and its effect was similar to that of the antiemetic regimen containing dexamethasone. In addition, the anxiety, depression and sleep disorders of patients in the olanzapine group were all improved to different degrees.Our study has provided a theoretical basis for the clinical application of the three-drug regimen of "dexamethasone removal".
Systematic review of OR to ICU handoff standardization interventions highlights need for focus on sustainability and patient outcomes
Authors: Busch Julian Maximillian Conn , Muralidharan Madhavi , Wu Jasmine , Taranti Laura J Di , Hernandez Enrique Torres , Collard Meredith L , Lane-Fall Meghan B 
Published: May 2022

Abstract
Background: Operating room (OR) to the intensive care unit (ICU) handoff standardization is a well-studied intervention to decrease preventable patient harm. We conducted a systematic review to synthesize findings about OR to ICU handoff intervention sustainability and the impact on handoff interventions on patient outcomes, neither of which are well described in recent reviews of OR to ICU handoff studies.Methods: Inclusion criteria included full papers (i.e., not abstracts) describing original research with intervention descriptions. There were no exclusion criteria. We searched 10 electronic bibliographic databases (including PubMed, Scopus, and eight others) for studies published between 1995 and October 2021 describing OR to ICU handoffs. We used the Cochrane Consumers and Communication Review Group Study Quality Guide to present and synthesize results using the criteria pertaining to the study format and PRISMA guidelines for reporting.Results: Our search yielded 41 papers published between 2007-2021. Thirteen (31.7%) of the studies described a sustainability period following the initial implementation phase that lasted 3-96 months. All studies with a sustainability period showed continued improvement of at least one study outcome. Nine studies measured patient outcomes, including unplanned or early extubations, delayed dosing of antibiotics, unspecified post-surgical complications, ICU-level patient mortality, among others. Of these, 7 (77.8%) reported statistical significance improvement of patient outcomes, but none were able to establish causation. Two studies reported no difference in any patient outcomes.Discussion: Interpretation of the evidence was limited by the risk of recall bias, Hawthorne effect, sampling bias, response bias, and no blinding of participants or personnel. Collectively, the evidence from all the studies examined is subject to both publication and selective reporting within studies. Overall, the studies demonstrate improvement in information exchange and clinician satisfaction with standardization but have not shown to cause improvement in patient outcomes. Only a few of these studies have focused on the sustainability of handoff standardization conventions. Overall, the field is heavily dominated by cardiac research and is lacking in sustainability research and patient outcome-correlated research.Other: Funding: The primary source of funding for this review was institutional funds.Register name: INPLASYRegister number: INPLASY202220035
Comprehensive analysis of a ceRNA network associated with TP53 mutations in liver hepatocellular carcinoma
Authors: Xu Zongren , Gan Hongyan , Li Ruiqian , Jia Junhao , Gao Lin , Yu Zicheng , Peng Jing , Yuan Jie 
Published: May 2022

Abstract
Background
Liver cancer is one of the most common causes of cancer-related death and is quantitatively dominated by the liver hepatocellular carcinoma (HCC) subtype. Although advances have been made in recent years, further exploration on new HCC carcinogenic mechanisms as well as diagnostic and therapeutic methods in the context of detrimental TP53 abnormalities is indispensable on the way to conquer HCC.
Methods
In this study, competing endogenous RNA (ceRNA) network was constructed on tumor samples stratified by the TP53 mutational status. Prognostic and therapeutic analyses were conducted on the identified network nodes. Multi-source databases were used for validations.
Results
The constructed ceRNA network demonstrated a TP53 mutant-specificity. Additionally, the ceRNA network nodes including AC017104.6, RP5-1092A11.5, RP11-365O16.6 and PTBP1 were all prognosis-related. Further therapeutic correlation analysis unveiled the connection between their expressions and tumor microenvironment fluctuation as well as possible chemotherapy resistance. We also explored the drug sensitivity difference between TP53 wild type and mutant samples, complementing the therapeutic arsenal of HCC. The universality of the key node PTBP1 was verified by transcription and protein level expressions.
Conclusions
This is the first study focusing on the ceRNA network mediated by TP53 mutations and its provoked therapeutic associations in HCC. Our results deepened the understanding of the concomitant alternations brought by TP53 mutations and could benefit future therapeutic development in HCC.
Enhanced Telehealth Home-Monitoring Intervention for Vulnerable and Frail Patients after Cardiac Surgery (THE-FACS Pilot Intervention Study)
Authors: Sarkar Shreya , MacLeod Jeffrey , Hassan Ansar , Brunt Keith , Palmer Krisan , Légaré Jean-François 
Published: May 2022

Abstract
BACKGROUND
Frail cardiac surgery patients have an increased risk of worse postoperative outcomes. The purpose of this study was to evaluate the implementation of a novel Telehealth Home monitoring Enhanced-Frailty And Cardiac Surgery(THE-FACS) intervention and determine its impact on clinical outcomes in frail patients post-cardiac surgery.
METHODS
Frail/vulnerable patients defined by Edmonton Frailty Scale(EFS > 4) undergoing cardiac surgery were prospectively enrolled(November 2019 -March 2020). Exclusion criteria included age < 55years, emergent status, minimally invasive surgery, lack of home support, and > 10-days postoperative hospital stay. Following standard training on THE-FACS, participants were sent home with a tablet device to answer questions about their health/recovery and measure blood pressure for 30-consecutive days. Transmitted data were monitored by trained cardiac surgery follow-up nurses. Patients were contacted only if the algorithm based on the patient’s self-collected data triggered an alert. Patients who completed the study were compared to historical controls. The primary outcome of interest was to determine the number of patients that could complete THE-FACS; secondary outcomes included participant/caregiver satisfaction and impact on hospital readmission.
RESULTS
We identified 86 eligible(EFS > 4), out of 254 patients scheduled for elective cardiac surgery during the study period(vulnerable:34%). The patients who consented to participate in THE-FACS (64/84, 74%) had a mean age of 69.1 ± 6.4 years, 25% were female, 79.7% underwent isolated CABG and median EFS was 6(5–8). 29/64 (45%) were excluded post-enrollment due to prolonged hospitalization(15/64) or requirement for hospital-to-hospital transfer(12/64). Of the remaining 35 patients, 21 completed the 30-day follow-up(completion rate:60%). Reasons for withdrawal(14/35, 40%) were mostly due to technical difficulties with the tablet. Hospital readmission, although non-significant, was reduced in THE-FACS participants compared to controls(0% vs. 14.3%). A satisfaction survey revealed > 90% satisfaction and ~ 67% willingness to re-use a home monitoring device.
CONCLUSIONS
THE-FACS intervention can be used to successfully monitor vulnerable patients returning home post-cardiac surgery. However, a significant number of frail patients could not benefit from THE-FACS given prolonged hospitalization and technological challenges. Our findings suggest that despite overall excellent satisfaction in participants who completed THE-FACS, there remain major challenges for wide-scale implementation of technology-driven home monitoring programs as only 24% completed the study.
Climatic Regions Based Molecular Prevalence of Babesiosis and Theileriosis in Cattle and Water- Buffalo in Pakistan
Authors: Zaman Muhammad Arfan , Atif Farhan A , Abbas Rao Zahid , Shahid Zohaib , Mehnaz Saba , Qamar Warda , Qamar Muhammad Fiaz , Hussain Kashif 
Published: May 2022

Abstract
This study was carried out to report prevalence of Babesia (B.) bigemina and Theileria (T.) annulata in cattle and water-buffalo (WB) from southern sandy zone (SSZ), central plain zone (CPZ), and northern arid zone (NAZ) of Pakistan in relation with breed, sex, age, housing system, season and feed. Towards this end, 6,510 blood samples (n = 2,170/each zone) were collected from suspected cattle and WB and were subjected to Giemsa staining and polymerase chain reaction (PCR). Logistic regression and odds ratios were applied for data analysis. Babesiosis and theileriosis was found highest (P < 0.05) in SSZ followed in order by NAZ and CPZ. Prevalence of theileriosis was observed higher than babesiosis and more common in cattle than WB. Prevalence of Babesiosis and theileriosis in cattle in Holstein Friesian (HF) breed, young age (> 16 months), tethered housing system, during summer season and in non-supplemented fed of cattle was found significant (P < 0.05). Prevalence of Babesia and Theileria in WB in Kundi breed, young age, tethered housing system, during summer season was found significant (P < 0.05). Odds ratio analysis showed all the determinants positively associated (OR > 1.00). The present studies provide evidence on endimicity of babesiosis and theirleriosis in the study area and naturally resilience of WB.
Potential biomarkers and immune characteristics of small bowel adenocarcinoma
Authors: Feng Jinggao , Tang Xiayu , Song Liusong , Zhou Zhipeng , Jiang Yuan , Huang Yao 
Published: May 2022

Abstract
Background: Small bowel adenocarcinoma (SBA) is a gastrointestinal malignancy with low incidence but poor prognosis, and its pathogenesis is still unclear. This study aimed to explore potential disease-causing biomarkers of SBA.Methods: The gene expression datasets of SBA and normal samples were downloaded from the Gene Expression Omnibus database. First, differential gene expression analysis and weighted gene co-expression network analysis (WGCNA) were performed. Common genes (CGs) were obtained by intersection of differentially expressed genes (DEGs) and optimal modal genes of WGCNA. Subsequently, a protein-protein interaction network was established to screen hub genes, and target genes were obtained by Lasso regression analysis of hub genes. An SBA risk prediction model was established based on target genes. The prediction accuracy of the model was evaluated by the area under the receiver operating characteristic curve (AUC). The levels of immune cell infiltration and activation of immune pathways were compared between SBA and normal samples using the "ggpubr" and "reshape2" packages.Results: A total of 1058 DEGs were identified. WGCNA showed that the signature gene in the brown module was significantly associated with SBA (p = 7E-17), and 469 CGs were obtained. Four target genes (APOA4, APOB, COL1A2, FN1) were identified and showed excellent prediction of SBA risk (AUC=0.965). In addition, active dendritic cells and macrophages showed higher infiltration levels in SBA. Meanwhile, the APC_co_stimulation pathway and parainflammation pathway were strongly active in SBA.Conclusions: Four target genes (APOA4, APOB, COL1A2, FN1) may be involved in the pathogenesis of small bowel adenocarcinoma.
Efficacy and safety of anti-PD-1/PD-L1 therapy in the treatment of advanced colorectal cancer: A meta-analysis
Authors: Li Yuegang , Du Yuwei , Xue Chi , Wu Pei , Du Nan , Zhu Guolian , Xu Huimian , Zhu Zhi 
Published: May 2022

Abstract
Background: Immune checkpoint inhibitors have shown promise in microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) advanced colorectal cancer (CRC) immunotherapy,andmany clinical trials have been conducted. Objective: To evaluate the efficacy and safety of PD-1/PD-L1 inhibitors in advanced CRC. Method: PubMed, Web of Science, Embase, and TheCochrane Library were searched for relevant studies up to September 2021. A retrospective cross-sectional data analysis was performed and Stata 16 software was used for analyses. Results:Sixteen studies including 1503 patients were analyzed. The objective response rate (ORR) of anti-PD-1/PD-L1 was 23% (95% CI: 0.14, 0.31); the overall 1-year survival rate (OSR) was 57% (95% CI: 0.42, 0.73). The ORR of MSI-H/dMMR advanced CRC was 37% (95% CI: 0.25,0.48) and that of microsatellite stable/mismatch repair proficient (MSS/pMMR) disease was 11% (95% CI: 0.06, 0.16). The ORR was 42% in the BRAF mutant subgroup and 19% in the RAS mutant group. The ORR was 14% in the PD-L1(+) subgroup and 32% in the PD-L1(-) subgroup. The rate of adverse effects was 85% (95% CI: 0.80, 0.91). Conclusion: Anti-PD-1/PD-L1 therapy in MSI-H/dMMR advanced CRC was associated with improved survival. Anti PD-1/PD-L1 combined with antiangiogenic drugs, targeted agents, or chemotherapy might be effective in MSS mCRC. Immunotherapy was effective for the BRAF mutant and KRAS/NRAS(RAS) mutant CRC. Low expression of PD-L1 was a potential predictive marker for positive response and outcome. The high incidence of adverse events at 85% was worthy of further investigation. Further analysis with a higher number of high quality studies is needed to verify the conclusions.
Evaluation of gaseous ozone virucidal efficacy against virus contamination on foods and packaging materials
Authors: Hu Kailei , Li Haichuan , Zhang Jingmin , Hu Yunfeng , Chen Junran , Han Jian 
Published: May 2022

Abstract
Diffusing of virus can occur through indirectly by contacting with food and surfaces of packaging materials being in the infected environment. Ozone proved effective in decontaminating pathogenic microorganisms on foods. To this end, this study explored the virucidal efficacy of gaseous ozone for foods and packaging materials by using three widely accepted viral surrogates (φ6, MS2, and φX174). The φ6 was highly disinfected (˃1.6-log reduction and 90% inactivation) by gaseous ozone (200 mg/h, 3 min) on foods except for peanut kernel. As observed, the same treatment had a little effect (˂ 0.19-log and 50% inactivation) on φX174 and MS2 on peanut kernel, even at the longer durations under the tested conditions (200 mg/h, 5 min, 6 min). On average, the adsorbed virus surrogates on soybean were better disinfected (˃70% inactivation). Hence, gaseous ozone could be a reliable way for inactivating φ6, φX174, and MS2 on soybean; however, continued efforts are needed to make gaseous ozone more applicable to peanut kernel. Gaseous ozone was effective for the inactivation of φ6, φX174, and MS2 on packaging materials. These results were encouraging as ozone treatment significantly reduced φ6, MS2 (＞1.19-log and 90% inactivation) on kraft paper, plastic, and glass panel, in which φX174 was disinfected over 70%. To conclude, gaseous ozone was an important technology for surface detoxification of foods and packaging materials because it could effectively control φ6, MS2 and φX174, but reducing the levels of viral surrogates on peanut kernel required new conditions.
The insoluble excretion of multi-matrix system mesalazine preparations in patients with ulcerative colitis
Authors: Ohtaki Yuichiro , Uchiyama Kan , Kamiya Hirotaka , Moriizumi Eri , Yamada Moe , Aoki Yuma , Watanabe Toshimune , Kiryu Sachie , Suzuki Shizuka , Matsumoto Yoshihiro , Ito Zensho , Ohkusa Toshihumi , Koido Shigeo , Saruta Masayuki 
Published: May 2022

Abstract
Background
Multi-matrix mesalazine (MMX) is an important treatment for ulcerative colitis (UC); however, it is often excreted intact, which increases the risk of relapse. This study aimed to clarify the risk factors for insoluble MMX excretion.
Methods
The subjects were 102 UC patients who were newly prescribed MMX alone to induce remission. Their stools were evaluated on the Bristol Stool Form Scale (BSFS), the presence/absence of insoluble MMX excretion was investigated in interviews, and the defecation frequency at the start of treatment and disease type were retrospectively investigated by examining their medical records.
Results
The insoluble excretion rate (IER) was 14.7%. It tended to be higher in the patients with left-sided colitis or extensive colitis, although the differences among the disease types were not significant (p = 0.053). The mean defecation frequency of the patients that reported insoluble MMX excretion was significantly higher than that of the patients that did not report it (6.27 ± 5.28 vs. 3.69 ± 3.17, p < 0.05). The IER tended to be higher among the patients with soft stools (4.5%, 21.9%, and 23.1% in those with BSFS scores of ≤ 4, 5, and ≥ 6, respectively). In ROC analysis of the defecation frequency, ≥ 3.5 defecations was found to exhibit sensitivity and specificity of 66.7% and 65.5%, respectively, for predicting insoluble MMX excretion. In the multivariate analysis, extensive colitis and a defection frequency of ≥ 4 times a day were extracted as independent risk factors for insoluble MMX excretion (OR: 5.041, 95%CI: 1.050-24.217; OR: 3.63, 95%CI: 1.105–11.922, respectively).
Conclusions
The likelihood of insoluble MMX excretion is influenced by defecation frequency and the extent of inflammation. It is important to keep the possibility of insoluble excretion in mind when prescribing MMX.