bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volatile-Mediated Induced and Passively Acquired Resistance in Sagebrush (Artemisia tridentata)
Authors: Grof-Tisza Patrick , Kruizenga Natasja , Tervahauta Arja I. , Blande James D. 
Published: August 2022

AbstractPlants produce a diversity of secondary metabolites including volatile organic compounds. Some species show discrete variation in these volatile compounds such that individuals within a population can be grouped into distinct chemotypes. A few studies reported that volatile-mediated induced resistance is more effective between plants belonging to the same chemotype and that chemotypes are heritable. The authors concluded that the ability of plants to differentially respond to cues from related individuals that share the same chemotype is a form of kin recognition. These studies assumed plants were actively responding but did not test the mechanism of resistance. A similar result was possible through the passive adsorption and reemission of repellent or toxic VOCs by plants exposed to damage-induced plant volatiles (DIPVs). Here we conducted exposure experiments with five chemotypes of sagebrush in growth chambers; undamaged receiver plants were exposed to either filtered air or DIPVs from mechanically wounded branches. Receiver plants exposed to DIPVs experienced less herbivore damage, which was correlated with increased expression of genes involved in plant defense as well as increased emission of repellent VOCs. Plants belonging to two of the five chemotypes exhibited stronger resistance when exposed to DIPVs from plants of the same chemotypes compared to when DIPVs were from plants of a different chemotype. Moreover, some plants passively absorbed DIPVs and reemitted them, potentially conferring associational resistance. These findings support previous work demonstrating that sagebrush plants actively responded to alarm cues and that the strength of their response was dependent on the chemotypes of the plants involved. This study provides further support for kin recognition in plants but also identified volatile-mediated associational resistance as a passively acquired additional defense mechanism in sagebrush.
Some Counterexamples to the Central Limit Theorem for Random Rotations
Authors: Czudek Klaudiusz 
Published: August 2022

AbstractFix an irrational number $$\alpha $$
α
, and consider a random walk on the circle in which at each step one moves to $$x+\alpha $$

x
+
α

or $$x-\alpha $$

x
-
α

with probabilities 1/2, 1/2 provided the current position is x. If an observable is given we can study a process called an additive functional of this random walk. One can formulate certain relations between the regularity of the observable and the Diophantine properties of $$\alpha $$
α
implying the central limit theorem. It is proven here that for every Liouville angle there exists a smooth observable such that the central limit theorem fails. We construct also a Liouville angle such that the central limit theorem fails with some analytic observable. For Diophantine angles some counterexample is given as well. An interesting question remained open.
Main product detection with graph networks for fashion
Authors: Yazici Vacit Oguz , Yu Longlong , Ramisa Arnau , Herranz Luis , van de Weijer Joost 
Published: August 2022

AbstractComputer vision has established a foothold in the online fashion retail industry. Main product detection is a crucial step of vision-based fashion product feed parsing pipelines, focused on identifying the bounding boxes that contain the product being sold in the gallery of images of the product page. The current state-of-the-art approach does not leverage the relations between regions in the image, and treats images of the same product independently, therefore not fully exploiting visual and product contextual information. In this paper, we propose a model that incorporates Graph Convolutional Networks (GCN) that jointly represent all detected bounding boxes in the gallery as nodes. We show that the proposed method is better than the state-of-the-art, especially, when we consider the scenario where title-input is missing at inference time and for cross-dataset evaluation, our method outperforms previous approaches by a large margin.
“How Do Shocks Affect International Reserves? A Quasi-Experiment of Earthquakes”
Authors: Ta Quy , Jinjarak Yothin , Noy Ilan 
Published: August 2022

AbstractWe evaluate the change in international reserves in the aftermath of significant external shocks by using a quasi-experimental setup and focusing on earthquakes. Our objective is to understand the macroeconomic dynamics of quake-affected countries ex-post, and their ex-ante disaster risk mitigation strategies. The estimation is done on a panel of 103 countries over the period 1979–2016. We find that in the five years following a large earthquake: (i) Countries exposed to it accumulate reserves ex-post for precautionary reasons, supported by the inflows of foreign assistance and money expansion; (ii) Quake-prone countries tend to hold fewer reserves relative to the non-prone countries, suggested by the richer set of other disaster preventive measures in place for the former; (iii) The patterns of reserves holding post-earthquake vary with a country’s income level and other macroeconomic fundamentals.
A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children
Authors: Nijstad A. Laura , Chu Wan-Yu , de Vos-Kerkhof Evelien , Enters-Weijnen Catherine F. , van de Velde Mirjam E. , Kaspers Gertjan J. L. , Barnett Shelby , Veal Gareth J. , Lalmohamed Arief , Zwaan C. Michel , Huitema Alwin D. R. 
Published: August 2022

Abstract
Background
Vincristine, a chemotherapeutic agent that extensively binds to β-tubulin, is commonly dosed at 1.4–2.0 mg/m2 capped at 2 mg. For infants, doses vary from 0.025–0.05 mg/kg or 50–80% of the mg/m2 dose. However, evidence for lower doses in infants compared to older children is lacking. This study was conducted to unravel the complex pharmacokinetics of vincristine, including the effects of age, to assist optimal dosing in this population.

Methods
206 patients (0.04–33.9 years; 25 patients < 1 years), receiving vincristine, with 1297 plasma concentrations were included. Semi-mechanistic population pharmacokinetic analyses were performed using non-linear mixed effects modelling.

Results
A three-compartment model, with one saturable compartment resembling saturable binding to β-tubulin and thus, saturable distribution, best described vincristine pharmacokinetics. Body weight and age were covariates significantly influencing the maximal binding capacity to β-tubulin, which increased with increasing body weight and decreased with increasing age. Vincristine clearance (CL) was estimated as 30.6 L/h (95% confidence interval (CI) 27.6–33.0), intercompartmental CL (Q) as 63.2 L/h (95%CI 57.2–70.1), volume of distribution of the central compartment as 5.39 L (95%CI 4.23–6.46) and of the peripheral compartment as 400 L (95%CI 357–463) (all parameters correspond to a patient of 70 kg). The maximal binding capacity was 0.525 mg (95%CI 0.479–0.602) (for an 18 year old patient of 70 kg), with a high association rate constant, fixed at 1300 /h and a dissociation constant of 11.5 /h.

Interpretation
A decrease of vincristine β-tubulin binding capacity with increasing age suggests that young children tolerate higher doses of vincristine.
Experimental and theoretical characterization of chelidonic acid structure
Authors: Makieieva Natalina , Kupka Teobald , Spaleniak Grzegorz , Rahmonov Oimahmad , Marek Agata , Błażytko Alfred , Stobiński Leszek , Stadnytska Nataliya , Pentak Danuta , Buczek Aneta , Broda Małgorzata A. , Kuś Piotr , Kusz Joachim , Książek Maria 
Published: August 2022

Abstract
Chelidonic acid (4-oxo-4H-pyran-2,6-dicarboxylic acid) is present in plants of Papaveraceae family, especially in Chelidonium majus. Due to its anticancer, antibacterial, hepatoprotective, and antioxidant properties, it has been used in medical treatments. In this work, the X-ray structure of methanol solvate of chelidonic acid was determined. Layers of chelidonic acid are held by hydrogen bonds via COOH and C = O fragments and additionally bridged by methanol. The formed H-bond network between two acid units is different from typical –COOH dimers observed, e.g., in crystals of isophtalic acid. The molecular structure of 2,6-dimethyl-γ-pyrone (2Me4PN) and chelidonic acid, a 2,6-dicarboxylic derivate of γ-pyrone (4PN), was verified in silico using density functional theory (DFT-B3LYP) combined with large correlation-consistent basis sets. The impact of –CH3 and –COOH substituents on 4PN ring structure, dipole moments, geometric/magnetic indexes of aromaticity, and NBO charges was assessed following unconstrained geometry optimization in the gas phase, chloroform, methanol, DMSO, and water with solvent effect introduced using the polarized continuous model (PCM). H-bond network formed in chelidonic acid–methanol complex was analyzed and their interaction energy estimated. Theoretical modeling enabled prediction of accurate structural parameters, dipole moments, and geometric/magnetic indexes of aromaticity of the studied 4PN, 2Me4PN, and chelidonic acid molecules.
Ought and agency
Authors: Skibra Daniel 
Published: August 2022

AbstractA thorny question surrounding the meaning ofoughtconcerns a felt distinction between deontic uses ofoughtthat seem to evaluate a state of affairs versus those that seem to describe a requirement or obligation to perform an action, as in (A) and (B), respectively. (A) There ought not be childhood death and disease. (B) You ought to keep that promise. Various accounts have been offered to explain the contrast between “agentive” and “non-agentive”oughtsentences. One such account is the Agency-in-the-Prejacent theory (“AIP”), which traces the difference to a particular kind of ambiguity in the prejacent. This theory has been criticized as linguistically unviable. Indeed, I level a few novel complaints against AIP myself in the present paper. But AIP has a kernel of genuine insight which allows us to explain the contrast—that the distinction between agentive and non-agentiveoughtsentences owes in part to the way natural language encodes information about agency. I develop this idea into a novel account that, like AIP, traces the contrast to an ambiguity in the complement of the modal. However, according to the view I propose, the Coercion View, a linguistically-motivated coercion operation produces the necessary grammatical conditions for agentiveought, which in turn allow a kind of variadic function operator in the style of (in: Recanati, Literal Meaning. Cambridge University Press, 2004) to produce the semantic effect we see on display in agentive readings ofought. Having explained the mechanism by which we get this structure, I show that it corroborates some of the central intuitions underwriting agentiveought. I submit that the Coercion View offers an explanation of agentiveoughtto take at least as seriously as any of its competitors.
Thromboembolism after treatment with 4-factor prothrombin complex concentrate or plasma for warfarin-related bleeding
Authors: Go Alan S. , Leong Thomas K. , Sung Sue Hee , Wei Rong , Harrison Teresa N. , Gupta Nigel , Baker Nicole , Goldstein Brahm , Ataher Quazi , Solomon Matthew D. , Reynolds Kristi ,   for the REVERSAL Study
Published: August 2022

AbstractLimited data exist in large, representative populations about whether the risk of thromboembolic events varies after receiving four-factor human prothrombin complex concentrate (4F-PCC) versus treatment with human plasma for urgent reversal of oral vitamin K antagonist therapy. We conducted a multicenter observational study to compare the 45-day risk of thromboembolic events in adults with warfarin-associated major bleeding after treatment with 4F-PCC (Kcentra®) or plasma. Hospitalized patients in two large integrated healthcare delivery systems who received 4F-PCC or plasma for reversal of warfarin due to major bleeding from January 1, 2008 to March 31, 2020 were identified and were matched 1:1 on potential confounders and a high-dimensional propensity score. Arterial and venous thromboembolic events were identified up to 45 days after receiving 4F-PCC or plasma from electronic health records and adjudicated by physician review. Among 1119 patients receiving 4F-PCC and a matched historical cohort of 1119 patients receiving plasma without a recent history of thromboembolism, mean (SD) age was 76.7 (10.5) years, 45.6% were women, and 9.4% Black, 14.6% Asian/Pacific Islander, and 15.7% Hispanic. The 45-day risk of thromboembolic events was 3.4% in those receiving 4F-PCC and 4.1% in those receiving plasma (P = 0.26; adjusted hazard ratio 0.76; 95% confidence interval 0.49–1.16). The adjusted risk of all-cause death at 45 days post-treatment was lower in those receiving 4F-PCC compared with plasma. Among a large, ethnically diverse cohort of adults treated for reversal of warfarin-associated bleeding, receipt of 4F-PCC was not associated with an excess risk of thromboembolic events at 45 days compared with plasma therapy.
Quantitative Study of Plasmonic Gold Nanostar Geometry Toward Optimal SERS Detection
Authors: Chung Taerin , Lee Sang-Hyuk 
Published: August 2022

AbstractComplex shapes of gold nanostars (GNS) have been the major obstacle to the comprehensive understanding of the rich plasmonic phenomena of GNS. We conducted extensive, systematic numerical study of far-field and near-field spectral responses of GNS for varying geometrical parameters (e.g., number of spikes, spike tip angle, and spike-to-core ratio) to elucidate the relationship between the optical property and the geometry of GNS. We found that symmetric configurations of GNS spikes generated both dipole and quadrupole localized surface plasmon (LSP) modes, their hybridization resulted in the final near-field intensity at the spike tips, and there existed a specific GNS geometry that optimized the hybridization and thus the E-field intensity for any given wavelength. From these results, we further identified the shapes of GNS that generated the strongest Surface Enhanced Raman Scattering (SERS) enhancement factors in the visible and NIR spectral range. Hence, our results provide guiding principles in determining the optimal geometry of GNS for SERS applications with any choice of excitation wavelength.
Student values and wellbeing in mathematics education: perspectives of Chinese primary students
Authors: Hill Julia L. , Seah Wee Tiong 
Published: August 2022

AbstractAround the world the prevalence of mathematics anxiety and disengagement point to a poor sense of student ‘mathematical wellbeing’. Mathematical wellbeing is defined here as the fulfilment of one’s ultimate or core values, accompanied by positive feelings and functioning in mathematics education. Yet student wellbeing and how to support it in specific school subjects including mathematics is vastly under-researched. Also, despite outperforming other countries in international mathematics assessments, East Asian students generally appear to experience poor affect and high academic burden in mathematics education, which are indicative of poor mathematical wellbeing. In this context, this explorative and descriptive study investigates the values that are associated with the mathematical wellbeing of a cohort of Chinese primary school students. 258 Grade three students in Chengdu, China responded to a questionnaire which explored teacher-nominated mathematics learning moments that students valued most for their mathematical wellbeing. Findings pointed to students valuing all the learning moments to some extent, with good grades, fun and interest, mathematics-themed videos, and teacher praise rated most commonly for wellbeing. The values underlying these learning moments are similar to the seven mathematical wellbeing dimensions found in Australian classrooms. The findings also highlight the cultural subjectivities involved, in which the same classroom actions can reflect different underlying values across cultures, and in which a particular value can be espoused in different ways in different places. We also look ahead to suggest how teachers might support students’ mathematical wellbeing, by recognising and then fulfilling their students’ values in the mathematics classroom.
Bioaccumulation, Biosedimentation, and Health Hazards of Elements in Crayfish, Procambarus clarkii from El-Rahawi Drain and El-Qanatir in the River Nile, Egypt
Authors: Abbas Mahmoud Mahrous M. , Abd El-Aziz Mohamed A.E. , Kaddah Mohamed M.Y. , Hassan Abdel-Kader , El-Naggar Hussein A. , Radwan Mahmoud , El-Tabakh Mohamed A.M. , Afifi Moharam A. , Bashar Mansour A.E. 
Published: August 2022

Abstract
Elements accumulation in crayfish is proportional to the increase in bioavailability (direct contact) with the surrounding water, sediment, and feeding. Five heavy metals (Cu, Cr, Mn, Ni, and Ag) and lithium (Li) were analyzed in the sediment, water, and crayfish tissues. Elements (heavy metals and lithium) concentrations in sediment, water, and crayfish tissues showed significant differences between the two sampling stations (El-Qanatir and El-Rahawi drain). However, the levels of elements in crayfish tissues were arranged in declining order as hepatopancreas > gills > exoskeleton > muscles for Cu and Cr; hepatopancreas > exoskeleton > gills > muscles for Ni and Ag; and exoskeleton > gills > hepatopancreas > muscles for Li and Mn. The human health hazard evaluation of heavy metals and lithium exposure via edible tissue consumption was assessed for both children and adult consumers. The target hazard quotient THQ values of crayfish edible tissues (less than 1) will not impose any health implications for consumers who ingest edible tissues in sufficient quantities. Furthermore, the hazard index (HI) values reported for children and adult consumers were lower than one, indicating non-carcinogenic and carcinogenic hazards, suggesting that crayfish edible tissues are safe for human ingestion. This evidence also found that Procambarus clarkii could be a good bio-indicator organism for monitoring potentially metals in aquatic systems.
Combination of levofloxacin and cisplatin enhances anticancer efficacy via co-regulation of eight cancer-associated genes
Authors: He Xiaoqiong , Yao ·Qian , Fan Dan , You Yutong , Lian Wenjing , Zhou Zhangping , Duan Ling 
Published: August 2022

AbstractChemosensitizer or combined chemotherapy can sensitize cancer cells to therapy and minimize drug resistance. We reveal that levofloxacin has broad-spectrum anticancer activity. Here we report that combination of levofloxacin and cisplatin further enhanced cytotoxicity in cancer cells by further promotion of apoptosis. Levofloxacin concentration-dependently promoted the inhibition of clone formation in cancer cells treated by cisplatin, and their combination further suppressed the tumor growth in mice. Levofloxacin and cisplatin co-regulated genes in directions supporting the enhancement of anticancer efficacy, of which, THBS1, TNFAIP3, LAPTM5, PI3 and IL24 were further upregulated, NCOA5, SRSF6 and SFPQ were further downregulated. Out of the 24 apoptotic pathways significantly enriched in the combination group, TNFAIP3, THBS1, SRSF6 and SFPQ overlapped in 14, 13, 3 and 1 pathway respectively. Jak-STAT/Cytokine-cytokine receptor interaction pathway network and extrinsic apoptotic signaling pathway were significantly enriched in levofloxacin group, cisplatin group and combination group. Jak-STAT/Cytokine-cytokine receptor interaction/Focal adhesion/EMC-receptor interaction pathway network was significantly enriched in the combination group, and IL24 and THBS1 were the overlapped genes. In conclusion, enhancement of anticancer efficacy in combination group was associated with the further regulation of THBS1, TNFAIP3, LAPTM5, PI3, IL24 and NCOA5, SFPQ, SRSF6. Targeting of Jak-STAT/Cytokine-cytokine receptor interaction/Focal adhesion/EMC-receptor interaction pathway network was correlated to the enhancement. With additional benefit to cancer patients for treatment or prophylaxis of an infectious syndrome, levofloxacin can benefit cancer chemotherapy no matter it is used independently or used with other chemotherapeutic drugs.
The views and experiences of people with type 2 diabetes being cared for by their community pharmacist: a cross-sectional patient survey
Authors: Cooney Philip , Hanley Jessie , Ryan-O’Brien Nicola , Okada Hiroshi , Bermingham Margaret 
Published: August 2022

Abstract
Purpose
Community pharmacists are highly accessible healthcare providers and studies in several countries have demonstrated a role for community pharmacists in delivering enhanced care to people with type 2 diabetes. The aim of this study is to evaluate the views and experiences of people with type 2 diabetes attending community pharmacies in Ireland.

Methods
A 13-item questionnaire, anchored on a 5-point Likert scale, was used. The study took place in seven pharmacies in the Munster region of Ireland. Participants were people attending a participating pharmacy who had type 2 diabetes and were aged ≥ 18 years.

Results
The questionnaire was answered by 125 people with type 2 diabetes. Mean age of participants was 65.7 ± 12.4 years and 59.2% were male. The statement “I am totally satisfied with my visit to this pharmacist”, was the item that participants most frequently agreed with (agree/strongly agree = 99.2%, mean score 4.9 ± 0.4). Over 80% of participants agreed or strongly agreed with the statement “It is easier to get to see the pharmacist than the doctor”, (mean score 4.3 ± 1.1).

Conclusion
In this population, people with type 2 diabetes were highly satisfied with the care provided to them by their community pharmacist. These data support the implementation of enhanced community pharmacy services for people with type 2 diabetes in Ireland.
Prediction of Iranian EFL teachers' burnout level using machine learning algorithms and maslach burnout inventory
Authors: Baniadamdizaj Shima , Baniadamdizaj Shahla 
Published: August 2022

AbstractBurnout results from constantly feeling emotional, physical, and mental stress. Most of the time, it is related to one's job and involves a sense of reduced accomplishment and loss of personal identity. Because accountability pressures, workload, and hours can increase stress, teachers are usually high achievers who like to work hard. They confront significant challenges. They must adapt curricula to a wide range of learning styles, manage to shift education policies, attend to students with special needs, and juggle administrative work. In addition, pay remains low in comparison with other graduate roles. Therefore, after prolonged exposure to poorly managed emotional and interpersonal job stress, many experience teacher burnout, resulting in employee turnover and many socio-economic problems. In this regard, accurate prediction provides essential research and decision-making benefits. To this aim, the Maslach Burnout Inventory was administered to a sample of 1433 Iranian EFL teachers. Moreover, nine different machine learning algorithms were implemented on the data set to predict burnout levels through the Python programming language. The algorithms' performances were also investigated through accuracy. In conclusion, the results of this study demonstrate the prediction of teachers' burnout levels to prevent the destructive consequences of the issue.