bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of transdermal carbon dioxide on changes in malondialdehyde levels as a marker of ischemia-reperfusion injury in patients with placenta accreta spectrum underwent temporary abdominal aortic cross-clamping as an adjunct procedure during cesarean hysterectomy
Authors: Pagehgiri Hari Daswin , Puruhito Ito , Aditiawarman  , Lestari Pudji , Sembiring Yan Efrata , Jiwangga Dhihintia , Hakim Arief Rakhman , Aryananda Rozi Aditya 
Published: December 2022

Background: Temporary abdominal aortic cross-clamping is often applied as an adjunct procedure to control bleeding in patients with placenta accreta spectrum during cesarean hysterectomy. It is claimed to reduce the blood loss need for transfusion and improve visualization of the operating field. After the cross-clamp is removed, the tissue distal to the occlusion, which was initially in an ischemic state, gets a sudden blood flow causing ischemia-reperfusion injury due to the release of ROS. Transdermal administration of carbon dioxide is expected to reduce the release of ROS through the Bohr Effect to protect against ischemia-reperfusion injury, which can be seen from the level of malondialdehyde.
Method: This experimental study recruited all patients with placenta accreta spectrum who underwent temporary abdominal aortic cross-clamping during cesarean hysterectomy from January to June 2022. Subjects were divided into control groups and treatment groups. The treatment group was given transdermal CO2 immediately after the aortic cross-clamp was removed. The plasma MDA levels were examined before and after aortic cross-clamping.
Results: The number of subjects in each group was 7 subjects. There was an increase in MDA levels from 19.779+0.870nmol/ml to 21.104+1.053nmol/ml after cross-clamp in all groups, with an average increase of 1.325+0.801nmol/ml (p=0.00). The treatment group that received transdermal CO2 had a lower tendency to increase MDA levels, 1.063+0.803nmol/ml, compared to the control group at 1.586+0.766nmol/ml.
Conclusion: There was an increase in MDA levels as a predictor of ischemia-reperfusion injury in patients undergoing temporary abdominal aortic cross-clamping. The administration of transdermal CO2 tends to suppress ischemia-reperfusion injury.
Peroneal tendon subluxation: A case report
Authors: Suehandika Caksana Putu , Wien Aryana I Gusti Ngurah , Zainarda Dr 
Published: December 2022

Background: Dislocation of the peroneal tendons is uncommon and is frequently misdiagnosed as an ankle sprain usually in young and active patients. The most common mechanism is a dorsiflexory force on the ankle associated with a rapid and strong contraction of the peroneal tendons and with eversion of the hindfoot, rapid contraction can also lead to injury to the superior peroneal retinaculum.Case Report: We reported a case of traumatic dislocation of the peroneal tendons. The patient was a 32-year-old who complained of right ankle pain and a feeling of dislocation after suffered an accident while playing football.Discussion: There have been many options reported for surgical repair of peroneal subluxation or dislocation. These include direct repair of peroneal retinaculum, reconstruction of peroneal retinaculum, bone block (lateral malleolus, sliding graft), and groove deepening and rerouting procedures.Reconstruction of the peroneal tendon can be accomplished using the peroneus brevis, plantaris, and/or Achilles tendons. Complications associated with these techniques include graft fracture, tendonitis, pain, and re-subluxation.Conclusions: Acute peroneal tendon dislocation is a challenging entity because it may mimic and frequently be misdiagnosed as an ankle sprain. Conservative treatment may be considered for acute dislocation but may be associated with high failure rate. There have been many options reported for surgical repair of peroneal subluxation or dislocation include direct repair of peroneal retinaculum, reconstruction of peroneal retinaculum, bone block (lateral malleolus, sliding graft), and groove deepening and rerouting procedures.Â Keywords: Peroneal Tendon, Subluxation, Dislocation, Ankle Injury.
Acute aortic dissection Stanford A DeBakey type III in patient with suspected Marfan Syndrome: a case report
Authors: Pandhika Karen , Mustika Aulia , Shodiq Muhammad Ali 
Published: December 2022

Background: Patients with Marfan syndrome can experience acute aortic dissection 77% with type A and 23% with type B, and 64% suffer from an aneurysm.Case Description: A 45 year old female admitted to intensive care with chest pain onset since 1 day ago, ECG examination shows sinus rhythm with normal axis. Chest x-ray shows dilatation and elongation of aorta with aorta aneurysm suspected. MSCT scan of thoracal shows dilatation of ascending aorta â€“ distal of left subclavian artery â€“ aortic arch â€“ descending aorta â€“ the thoracoabdominal aorta â€“ right and left common iliac artery. On blood examination, we found elevation of D-dimer (3570 Âµg/L). Patient was given beta-blockers to control heart rate 60 beats per minutes, CCB and ACE inhibitor was given to control systolic below 110 mmHg. After putting so much thought, patient was scheduled for TEVAR procedure.Conclusion: Patients with Marfan syndrome tend to have thoracic aortic aneurysms involving aortic root, ascending aorta, arch, and descending thoracic aorta. TEVAR is minimal invasive procedure and Â have good outcome in patient with aortic dissection.
EFFECT OF ORAL IRON TABLET ADMINISTRATION ON SERUM FERITIN AND HEMOGLOBIN CONCENTRATION OF PRE-PREGNANT WOMEN WITH MILD IRON DEFICIENCY ANEMIA IN BALI
Authors: Seri Ani Luh , Bakta I Made , Suryadhi INT , Agus Bagiada IN 
Published: December 2022

Iron deficiency anemia (IDA) is still to be a problem of pregnant women healthrelated to its high prevalence and its negative effects on health. Prevention efforts by ironsuplementation in pregnant woman have not reducing IDA problem in pregnant women yet.Â This failure is probably due to the assumption that IDA have been seen pre-pregnant. Totest this hypothesis, a quasi experimental study was conducted by randomized pre and posttest control group design. Sample were collected by multistage sampling random technicconsist of 47 women in treated group and 52 in control group. Both group were serumferritin and hemoglobin value test untill 3 time, pre-pregnant, early pregnant and duringpregnant. Iron tablet was administrated to treated group from the beginning of pre-pregnantperiod, continued until the first 3 months of pregnancy, while in control group iron tabletwas only given during the first 3 months of pregnancy. T-group result shown that meanserum ferritin and hemoglobin concentration at pregnant women on treated group(33,45Â±14,12 ?g/dL dan 12,25Â±1,20 g/dl) more high than control group (19,65Â±8,99 ?g/dLdan 10,91Â±0,67 g/dl), p<0,05. Mean difference serum ferritin and hemoglobinconcentration at pregnant women is 13,8 ?g/dL dan 1,34 g/dl (p<0,05). Benefid analysisresult shown that iron suplementation since pre-pregnant more benefid than ironsuplementation during pregnant (BCR >1). Based on these results, it can be concluded thatiron supplementation to IDA women starting from pre-pregnant period results in a bettereffect compare to oral iron supplementation during pregnancy only.
FLOUXETINE IMPROVED INTRAVAGINAL EJACULATORY LATENCY TIME THROUGH DECREASED LEVELS OF INTERFERON-GAMMA AND INCREASED LEVELS OF SEROTONIN IN PATIENT WITH PREMATURE EJACULATION
Authors: I M. Nyandra , W Pangkahila , A. A. Raka-Sudewi , I N. A. Bagiada 
Published: December 2022

Pathophysiology of premature ejaculation (PE) is very complex because it is associated with many factors, which can be grouped into biological factors and psychological factors. Various diseases have been found correlate between psychological factors and biological factors through cytokines, one of which is IFN-y (IFN-g). IFN-y affect indolamine dioxygenase enzyme (IDO) and decrease levels of serotonin. Low levels of serotonin leads to PE. The purpose of this study was to prove the relationship of serotonin and IFN-y in pathophysiology of PE.This study was designed as a pretest-posttest double-blind cross-over control group design. Patients with PE were divided into 2 groups: control group and treatment group. Treatment group received flouxetine 20 mg for 30 days. Then the control and treatment groups were crossed after passing a 14-days washout period. Previously as a control group to treatment group and received flouxetine 20 mg per day for 30 days. Before and after treatment in each group was examined the levels of serotonin and IFN-y.Of the 26 subjects, each group there was 13 subjects. Flouxetine 20 mg per day for 30 days increased serotonin levels were significantly (pÂ < 0.05), and decreased levels of IFN-y were significantly (pÂ < 0.05). Increased levels of serotonin and decreased levels of IFN-y was significantly associated with improvements (intravaginal ejaculatory latency time) ejaculation in PE patient.From these results it can be concluded that PE occurs because decreased levels of serotonin. Decreased levels of serotonin are associated with increased levels of IFN-y.Â
NUTRITION STATUS CORRELATED TO THE FIRST PERMANENT MANDIBULAR MOLAR TEETH OF ELEMENTARY SCHOOL CHILDREN IN LINTAU BUO, TANAH DATAR REGENCY, WEST-SUMATRA
Authors: A. Syukra 
Published: December 2022

The first permanent mandibular molar teeth is the most important for child, especially to stimulate growth of jaw. The teeth has normally erupted at children age of 6-7 years old. However, it is frequently not happened at this stage. This study aims to determine the nutritional status relate to the first permanent mandibular molars teeth eruption in the elementary school children age of 6-7 years old at Lintau Buo, Tanah Datar Regency, West-Sumatra Indonesia.This is an analytical cross-sectional study, with anthropometric measurements of body mass index/BMI of elementary school children related to eruption of the first permanent mandibular teeth.The results showed that nutritional status of elementary school children age of Â 6-7 years old for the most were within normal category (51.2%). Grade-I (6-7 years old) suffered from emaciation is still quite high (45.4%), 20.3% of 187 students who suffer from emaciation first permanent mandibular molars have erupted, the first permanent mandibular molars in first grade children (6-7 years old) with normal nutritional status, risk of overweight and obese have erupted.Nutritional status affects childrenâ€™s first permanent mandibular molar erupted lower jow. The better the nutritional status of a child then the erupstion of the Â first mandibular molars Â will get better and grow in time.
CANTHARANTHUS ROSEUS LEAF EXTRACT ACCELERATES HEALING OF WOUND WISTAR RAT
Authors: Anom-Dada I K. , Berata I K. , Putra-Manuaba I. B. , Damriyasa I M. 
Published: December 2022

Cantharantus roseus (C. roseus)Â is a medical plant that has been used to treat various diseases. This study was carried to determineÂ C. roseusÂ leaf extract able to acclerate wound healing in Wistar rat. Full skin-tickness round wounds were created on the back of the rats. Wound healing was evaluated after treated with 15% of a mixture of leaf extract ofÂ C. roseusÂ and vaseline. The rats were divided into two groups, each group consist of 16 rats. Wound healing was assesed in five and fifteen days after treatment by measuring wound area, wound closure, and counting the new capillary vessel number (angiogenesis). The result of the study indicated that extract ofÂ C. roseusÂ leaf accelerates the wound healing in Wistar rat. Coverage rate of wound is faster on treated group than control group (p<0.05). Wound closure and angiogenesis in early wound healing were higher in treated group than control group (p<0.05). These results suggested that the first phase of wound healing was shortened, and the proliferative and maturation phases were advanced by methanol extract ofÂ C. roseusÂ leaf. Therefore, it can be concluded thatÂ C. roseusÂ could be potential to help in topical management of wound healing.
MASSAGE STIMULATION REDUCES TUMOR NECROTIC FACTOR-ALPHA AND INTERLEUKIN-6 IN PRETERM, LOW BIRTH WEIGHT WITH APPROPRIATE GESTATIONAL AGE NEWBORNS
Authors: Trisna Windiani I G. A. , Sotjiningsih S. , Mantik Astawa N. , Kusnandi R. 
Published: December 2022

Preterm newborn is susceptible from various stresses such as infections or non infections. During stress, immune response is activated by synthesizing and releasing of cytokines from activated immune cells into the circulation. One of the efforts to overcome the stress is massage stimulation. Several studies have been carried out to find out the benefit of massage stimulation. The objective of this study is to find out the effect of massage stimulation to reduce of TNF-Î± and IL-6 levels on preterm, low birth weight, appropriate to gestational age newborn. This was a randomized controlled trial. Subjects of the study were all preterm newborns with a stable medical condition, birth weight 1,500-2,499 gram, appropriate to gestational age. The study was carried out on October-December 2011, in neonatology ward, Sanglah General Hospital, Vali-Indonesia. The number of cases was 35 subjects and the number of controls was 36 subjects. The examination of TNF-Î±, IL-6 levels and birth weights before and after massage stimulation were performed on both groups. The level of TNF-Î± and IL-6 was examined by applying ELISA method. The level of confidence was Î± Â = 0.05. All statistical analysis was performed by computer programme. There was different level of cytokine pro-inflammation TNF-Î± (p=0.025) and IL-6 (p=0,001) comparing before and after condition massage stimulation. Outcome of body weight were also different at before and after massage stimulation, withÂ p valueÂ 0.042. The conclusion of this study is that massage stimulation can reduce the level of TNF-Î± , Â Â IL-6 and increasing of birth weight on preterm, low birth weight appropriate gestational age newborn. Based on this study, in the future, massage stimulation can be done in newborn with stable medical conditions by parents or trained staffs.
HIGH INTERLEUKIN-6, LOW CD4+ AND CD8+ T-LYMPHOCYTES EXPRESSIONS AS RISK FACTORS OF CERVICAL CARSINOMA INFECTED BY HUMAN PAPILLOMA VIRUS TYPE-52
Authors: Mahendra-Dewi I G. A. S. , Suwiyoga I K. , Joewarini E. , Alit-Artha I G. 
Published: December 2022

In Indonesia cervical carcinoma is the most common cancer in women and one of the leading cause of mortality. High risk human papillomavirus (HPV) is the major risk factor of cervical cancer. This study aims to know the role of IL-6, CD4+Â and CD8+Â T-lymphocyte for the risk of cervical carcinoma infected by HPV52. This study was a case control study, specimens of cervical carcinoma patients infected by HPV type-52 as the case group and HPV type-16 or 18 as the control group. HPV genotyping used SPF10 primer and type specific E7 primer by LiPA. Immunohistochemistry method was used to know expression of IL-6, CD4+Â and CD8+Â T lymphocyte. Pearsonâ€™s c2Â test was applied with statistical significance was set at the 2-sided 0.05 level. The odds ratios (OR) were calculated for the risk, with 95% confidence intervals on SPSS 16.0 for windows. PCR examination was performed in 185 paraffin-embedded tissue. The risk of high IL-6 expression in cervical carcinoma infected by HPV type-52 was statistically significant 6-fold higher compare with cervical carcinoma infected by HPV type 16 (OR = 6.00 ; CI 95% = 1.13-31.99; p = 0.03; p < 0.05) and HPV type 18 (OR = 6.00 ; CI 95% = 1.13-31.99; p = 0.03; p < 0.05). The risk of low CD4+Â T lymphocyte expression in cervical carcinoma infected by HPV type 52 was statistically significant 6-fold higher and 7.43-fold higher respectively compare with cervical carcinoma infected by HPV type 16 (OR = 6.00 ; CI 95% = 1.003-35.91; p = 0.04; p < 0.05) and HPV type 18 (OR = 7.43 ; CI 95% = 1.23-45.01; p = 0.02; p < 0.05). The risk of low CD8+Â T lymphocyte expression in cervical carcinoma infected by HPV type 52 was statistically significant 13.5-fold higher and 11-fold higher respectively compare with cervical carcinoma infected by HPV type 16 (OR = 13.50 ; CI 95% = 1.42-128.26; p = 0.01; p < 0.05) and HPV type 18 (OR = 11.00 ; CI 95% = 1.16-103.94; p = 0.02; p < 0.05). No significance different between cases and controls group in mean-age, parity and sexual activity (p > 0.05). In conclusion, this study found that high IL-6 expression, low CD4+Â and CD8+Â T lymphocyte expression were the risk factors of cervical carcinoma infected by HPV type 52.
AMPLICATION OF 0.7KB FRAGMENT KATG GENE FROM CLINICAL MULTI DRUG RESISTANT TUBERCULOSIS ISOLATE IN BALI
Authors: Dwiputri A. W. , Ratnayani K. , Yowani S. C. 
Published: December 2022

During last decade has seen a particular increase in the occurrence of drug-resistant of tuberculosis (DR-TB) and multi-DR strains, such as Isoniazid (INH) resistant strains ofÂ M. tuberculosis. Â INH resistance is more frequently associated with mutations in theÂ katGÂ gene. Detection ofÂ katGÂ gene mutations can be performed by PCR technique, followed by sequences. The aim of this study is to amplifyÂ katG gene region (0,7 Kb) from clinical isolate of MDR-TB in Bali. DNA isolation for PCR was done by Boom method andÂ katGÂ gene amplification was performed under the following conditions: predenaturation at 950C for 15 min; fourty cycles of denaturation at 940C for 1 min, annealing at 560C for 1 min, extension at 720C for 2 min; final extension at 720C for 10 min. The amplicons were detected by 1.5% agarose gel electrophoresis and showed a specific band size at 0.7 kb. This suggests that the fragment ofÂ katGÂ gene has been successfully amplified in these areas.
Karakteristik pasien batu ginjal dengan tatalaksana retrograde intra-renal surgery di Rumah Sakit Umum Pusat Sanglah dan Rumah Sakit Surya Husada: initial report tahun 2017-2019
Authors: Sabudi I Made Nugraha Gunamanta , Duarsa Gede Wirya Kusuma , Santosa Kadek Budi , Yudiana I Wayan , Tirtayasa Pande Made Wisnu , Pramana Ida Bagus Putra , Oka Anak Agung Gde 
Published: December 2022

Background: Renal stone is frequent cases that happened in the community. There are a lot of options to treat renal stone; one of them is RIRS. RIRS is an alternative procedure after ESWL and PNL for renal stone.Method: Twenty-seven samples as total sampling of all patients that were done with RIRS in Sanglah Hospital and Surya Husada Hospital from January 2017 until June 2019 retrospectively. Data were collected secondary from Medical Reports of the patients and showed a descriptive study depict how the RIRS patient characteristic in Sanglah Hospital and Surya Husada Hospital. All RIRS patients showed that the RIRS procedure is secondary due to history of ESWL, PNL, URS with insertion of DJ Stent, and or Nephrolithotomy.Results and Conclusion:Characteristic of age in this study was 52,41 years old in mean value, with male and female per cent, respectively 62,96% and 37,04%. Stone size of the study was classified to 4 cluster which are: (1) 37,04% cluster with stone size <1 cm, (2) 33,33% cluster with stone size â‰¥1cm to <2cm, (3) 3,70% cluster with stone size â‰¥2 cm, and (4) 25,93% cluster that with stone size unknown. This study also showed some similarity with two other studies about patient characteristic of RIRS treatment.Â Latar Belakang: Batu ginjal adalah kasus yang sering terjadi di masyarakat. Terdapat banyak pilihan tindakan untuk mengambil batu ginjal salah satunya adalah dengan tindakan RIRS. Tindakan RIRS masih menjadi alternatif tindakan setelah pilihan pertama PNL dan ESWL untuk batu ginjal.Metode: Penelitian ini mengambil 27 sampel pasien dari total sampling seluruh pasien yang dilakukan RIRS di Rumah Sakit Umum Pusat (RSUP) Sanglah dan Rumah Sakit (RS) Surya Husada selama Januari 2017 hingga Juni 2019 secara retrospektif. Data didapatkan dari data sekunder rekam medis pasien. Penelitian disajikan secara deskriptif memberikan gambaran karakteristik pasien yang mendapatkan tindakan RIRS. Seluruh pasien yang dilakukan RIRS di RSUP Sanglah dan RS Surya Husada merupakan pasien dengan mendapat RIRS Sekunder setelah sebelumnya memiliki riwayat pernah ESWL, PNL, URS dengan pemasangan DJ-stent, dan atau nefrolitotomi.Hasil dan Simpulan: Karakteristik usia rata-rata pada penelitian ini adalah 52,41 tahun dengan perbandingan persentase laki-laki perempuan berturut-turut 62,96% dan 37,04%. Ukuran batu pada penelitian dikelompokkan menjadi 4 kelompok dengan masing-masing kelompok: (1) 37,04% kelompok dengan ukuran batu <1 cm, (2) 33,33% kelompok dengan ukuran batu â‰¥1cm s/d <2cm, (3) 3,70% kelompok dengan ukuran batu â‰¥2 cm, (4) 25,93% kelompok yang ukuran batunya tidak tercantum.
Pengaruh puasa berselang terhadap berat badan pada mahasiswa Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Udayana
Authors: Adi Supraba Putu Ayu , Sutadarma I Wayan Gede , Wiryanthini Ida Ayu Dewi 
Published: December 2022

Background: Body weight is used as a measure of body mass in kilogram (kg). The way which is effective for weight loss is a lifestyle changes like diet and exercise. Besides low calorie diet, we can do intermittent fasting to prevent overweight and obesity.Aim: This research aims to know the effect of intermittent fasting on body weight in young adult group.Methods: This research uses pretest-posttest control group design which was conducted during Ramadhan fasting in 2017 in the Department of Physiology, Faculty of Medicine, Udayana University. The subject is divided into two groups, namely fasting group and unfasting group as many as 40 people, respectively. The data include weight before and after fasting.Results: Normality test obtained both fasting groups with p=0.326 and unfasting one with p=0.317, so that both groups are homogenous. Paired-sample t test on the weight for the beginning and end of the fasting group obtained the value of p=0.000, whereas in unfasting group obtained 0.149.Conclusion: Intermittent fasting affects early weight loss and final body weight on fasting group consequently. As for the unfasting group, it was obtained no significant distinction between initial weight compare with latest weight. Latar belakang: Berat badan digunakan sebagai ukuran massa tubuh dalam kilogram (kg). Cara yang paling efektif untuk menurunkan berat badan adalah perubahan gaya hidup meliputi diet dan olahraga. Selain diet rendah kalori, cara untuk mencegah kelebihan berat badan dan obesitas adalah puasa berselang.Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh puasa berselang terhadap berat badan pada kelompok dewasa muda.Metode: Penelitian ini menggunakan pretest-posttest groups control design yang dilakukan saat puasa Ramadhan 2017 di bagian Fisiologi Fakultas Kedokteran Universitas Udayana. Subjek penelitian dibagi menjadi dua kelompok yaitu kelompok puasa dan kelompok tidak puasa yang masing-masing berjumlah 40 orang. Data yang diambil meliputi berat badan sebelum dan sesudah puasa.Hasil: Hasil uji normalitas didapatkan untuk kelompok puasa dengan p=0.326 dan kelompok tidak puasa p=0.317 yang berarti kedua kelompok homogen. Pada uji t-test berpasangan untuk berat badan awal dan akhir pada kelompok puasa didapatkan nilai p=0.000, sedangkan pada kelompok tidak puasa didapatkan nilai p= 0.149.Simpulan: Puasa berselang berpengaruh terhadap penurunan berat badan awal dan berat badan akhir pada kelompok puasa. Sedangkan bagi kelompok tidak puasa, tidak didapatkan perbedaan yang bermakna antara berat badan awal dengan berat badan akhir.