bluuebunny/crossref_metadata_2025_split huggingface dataset:
Articulation of the cross-boundary effects of China’s ecological conservation redline program: A perspective on the ecological security network and ecological radiation
Authors: Du Fujun , Gao Jiangbo , Zuo Liyuan , Jiang Yuan 
Published: September 2022

China’s Ecological Conservation Redline (ECR) program ensures the coordination and sustainability of natural and economic development while maintaining regional ecological security. Current research focuses on the ecosystem services within ECR areas but ignores cross-boundary ecological flow and the interactions between the internal and external ecological effects of ECR areas. In addition, the ecological background has spatial continuity that is not limited by boundaries, and the radiation effect areas extending beyond ECR areas have not been quantified. In this study, the Beijing ECR areas and ecological security network were integrated in order to connect the ecological process and landscape pattern to the ECR through the circulation path of ecological corridors, and cross-boundary effects between patches were examined. The field spread model was used to quantify the radiation influence range of ECR areas. Additionally, 972.46 km of ecological corridors were identified in Beijing, and abundant corridors effectively linked the ECR areas and maintained the material cycle. In the surrounding areas, ecological corridors were spread radially, with a total length of 941.85 km, promoting cross-boundary ecological flow between the ECR and surrounding source areas. This study used 25 ecological nodes to constitute the cross-boundary ecological security network system. The total radiation area based on the ECR source was 9572.16 km2. These results provide support for the radiation effect of ECR and cross-boundary ecological flows and suggest a useful model for sustainable ecological development and cross-boundary management.
Risk Factors for Anterior Cruciate Ligament Graft Failure in Professional Athletes: An Analysis of 342 Patients With a Mean Follow-up of 100 Months From the SANTI Study Group
Authors: Hopper Graeme P. , Pioger Charles , Philippe Corentin , El Helou Abdo , Campos Joao Pedro , Gousopoulos Lampros , Carrozzo Alessandro , Vieira Thais Dutra , Sonnery-Cottet Bertrand 
Published: September 2022

Background:Anterior cruciate ligament (ACL) injuries are among the most common knee injuries sustained in elite sport, and athletes generally undergo ACL reconstruction (ACLR) to facilitate their return to sport. ACL graft rupture is a career-threatening event for elite athletes.Purpose/Hypothesis:The purpose of this study was to determine the risk factors for graft failure in professional athletes undergoing ACLR. It was hypothesized that athletes who underwent combined ACLR with a lateral extra-articular procedure (LEAP) would experience significantly lower rates of graft rupture in comparison with those who underwent isolated ACLR.Study design:Cohort study; Level of evidence, 3.Methods:Professional athletes who underwent primary ACLR with a minimum follow-up of 2 years were identified from the Santy database. Patients were excluded if they underwent major concomitant procedures, including multiligament reconstruction surgery or osteotomy. Further ipsilateral knee injury, contralateral knee injury, and any other reoperations or complications after the index procedure were identified by interrogation of the database and review of the medical notes.Results:A total of 342 athletes with a mean follow-up of 100.2 ± 51.9 months (range, 24-215 months) were analyzed. Graft failures totaling 31 (9.1%) were reported, requiring revision surgery because of symptomatic instability. The rate of graft failure was significantly higher when ACLR was not combined with a LEAP (15.5% vs 6.0%; P = .0105) and in athletes aged 21 years or younger (13.8% vs 6.6%; P = .0290). A multivariate analysis was performed using the Cox model and demonstrated that athletes undergoing an isolated ACLR were at >2-fold risk of ACL graft rupture (hazard ratio [HR], 2.678 [1.173; 4.837], P = .0164) when compared with those undergoing a combined ACLR with a LEAP. Additionally, athletes aged ≤21 years were also at >2-fold risk of graft failure (HR, 2.381 [1.313; 5.463]; P = .0068) than those aged >21 years. Sex, sport, and graft type were not found to be significant risk factors for graft failure.Conclusion:Professional athletes undergoing isolated ACLR and aged ≤21 years are at >2-fold greater risk of graft failure. Orthopaedic surgeons treating elite athletes should combine an ACLR with a LEAP to improve ACL graft survivorship.
Does Femoral Osteoplasty Improve Long-term Clinical Outcomes and Survivorship of Hip Arthroscopy? A 15-Year Minimum Follow-up Study
Authors: Nepple Jeffrey J. , Parilla Frank W. , Ince Deniz C. , Freiman Serena , Clohisy John C. 
Published: September 2022

Background: Although femoral osteoplasty is common practice in treating cam-type femoroacetabular impingement (FAI), long-term data are lacking that support the ability of this procedure to optimize outcomes and alter natural history. Purpose: To compare long-term clinical outcomes and survivorship of treatment for symptomatic FAI via arthroscopic correction of labral or chondral pathology with and without femoral osteoplasty. Study Design: Cohort study; Level of evidence, 3. Methods: A retrospective cohort study was performed across 2 consecutive cohorts of patients with isolated cam-type FAI who underwent hip arthroscopic treatment of labral or chondral pathology without femoral osteoplasty (HS group) or with femoral osteoplasty (HS-OST group). These unique cohorts were established at a distinct transition time in our practice before and after adoption of femoral osteoplasty for treatment of FAI. Clinical outcomes were measured using the modified Harris Hip Score (mHHS). Kaplan-Meier analysis was used to assess for total hip arthroplasty (THA)–free and reoperation-free survivorship. Results: The final HS group included 17 hips followed for 19.7 ± 1.2 years, and the final HS-OST group included 23 hips followed for 16.0 ± 0.6 years. No significant patient or morphological differences were found between groups. Compared with the HS group, the HS-OST group had significantly higher final mHHS (82.7 vs 64.7 for HS-OST vs HS, respectively; P = .002) and mHHS improvement (18.4 vs 6.1; P = .02). The HS-OST group also had significantly greater 15-year THA-free survivorship versus the HS group (78% vs 41%, respectively; P = .02) and reoperation-free survivorship (78% vs 29%; P = .003). Conclusion: This study demonstrated superior long-term clinical outcomes and survivorship with combined arthroscopy and femoral osteoplasty compared with hip arthroscopy alone. These long-term data strongly support the practice of femoral osteoplasty in patients with cam FAI morphologies and suggest that this treatment alters the natural history of FAI at long-term follow-up.
Advancing Healthy Food Service in the United States: State Food Service Guidelines Policy Adoption and Implementation Supports, 2015-2019
Authors: Lowry-Warnock Amy , Strombom Nicole , Mugavero Kristy , Harris Diane , Blanck Heidi M. , Onufrak Stephen 
Published: September 2022

Purpose Food service guidelines (FSG) policies can impact the nutritional quality of millions of meals sold or served to government employees, citizens in public places, or institutionalized persons. This study examines state FSG policies adopted January 1, 2015 to April 1, 2019, and uses a FSG Classification Tool (FSG Tool) to quantify alignment with nutrition recommendations for public health impact. Design Quantitative Content Analysis Setting State Government Worksites and Facilities Participants 50 states and District of Columbia (D.C.) in the United States. Measures Frequency of policies and percent alignment to FSG tool. Analysis FSG policies were identified using legal databases to assess state statutes, regulations, and executive orders. Content analysis and coding determined attributes of policies across 4 FSG Tool domains, (1) nutrition standards referenced; (2) behavioral design strategies encouraging selection of healthier offerings; (3) facility efficiency and environmental sustainability; and (4) FSG implementation supports. Results From 2015-2019, 5 FSG policies met study inclusion criteria. Four out of 5 policies earned a perfect nutrition score (100%) by referencing nutrition standards that align with the Dietary Guidelines for Americans (DGA) and are operationalized for use in food service venues. Four out of 5 policies included at least 1 implementation supports provision, such as naming an implementing agency, and 2 included provisions that encourage local food sourcing. Conclusion From 2015-2019, overall FSG policy comprehensiveness scores ranged from 24% to 73%, with most policies referencing food and nutrition standards that align to national nutrition recommendations. Public health practitioners can educate decision makers on the potential impact of FSG policies on diet-related health outcomes and associated cost savings, as well as other important co-benefits that support locally grown products and environmental sustainability practices.
Antiphospholipid syndrome in patients over 65 years: A comparative study of clinical and biological features and thrombotic relapses
Authors: Masson Colombe , An Nguyen Thi T. , Dufrost Virginie , Audrain Marie , Hémont Caroline , Agard Christian , Artifoni Mathieu , Connault Jérôme , Fouassier Marc , Hamidou Mohamed , Guedon Alexis F , Wahl Denis , Zuily Stéphane , Espitia Olivier 
Published: September 2022

Objective The aim of the study was to describe clinical and biological characteristics and thrombotic relapses of patients diagnosed with antiphospholipid syndrome (APS) after the age of 65 years, in comparison with patients diagnosed with APS before 65. Methods This retrospective multicenter study was performed to 2005 from 2017 and included patients diagnosed with APS after the age of 65 years, in accordance with Sydney criteria. We compared these patients with APS patients diagnosed before the age of 65 years, and with control thrombotic patients older than 65 years. Results Fifty-eight APS patients over the age of 65 years were compared to 127 APS patients aged less than 65 and to 58 controls. In elderly APS versus younger APS, there was a male predominance (58.6% vs 36.2% p = .001); myocardial infarction and lower limb deep vein thrombosis (LLDVT) were more frequent in elderly, respectively, 12.1% versus 1.6% ( p = .005), and 44.8% versus 29.9% ( p = .048). Anticardiolipin antibody (aCL) IgM was more frequently found in old patients compared to younger patients (33.9% vs 18.1%, p = .02), contrary to lupus anticoagulant (LAC) (52.8% vs 66.9%, p = .02). Older patients were more often diagnosed with single positive APS (82.8% vs 59.8% p = .002). The thrombotic relapse free survival was lower in elderly APS patients ( p = .044) compared to younger APS. Elderly APS patients had more recurrent arterial and venous thrombosis ( p = .03) and had poorer overall survival ( p = .004) than elderly controls. Conclusion In this study, APS was different in patients aged more than 65 years, with a male predominance and more myocardial infarctions and LLDVT at diagnosis. Single antiphopholipid positivity and aCL IgM were more frequent in older patients. Older patient with APS had more thrombotic recurrence during follow-up. Compared to elderly controls, elderly APS patients had more thrombosis recurrences and poorer survival.
The mSteps pilot study: Analysis of the distance walked using a novel smartphone application in multiple sclerosis
Authors: Alexander Sarah , Braisher Marie , Tur Carmen , Chataway Jeremy 
Published: September 2022

Background: Clinical studies in multiple sclerosis (MS) often require accurate measurement of walking distance. Utilisation of electronic devices could theoretically improve this. Mobile devices have the potential to continuously monitor health by collecting movement data. Popular fitness trackers record steps taken and distance travelled, typically using a fixed-stride length. However, applications using fixed-stride length may be less accurate in those with altered gait patterns. While useful for everyday purposes, medical monitoring requires greater accuracy. Objective: Our aim was to determine the agreement and reliability of using a smartphone application to measure distance walked. Method: A phone application (mSteps) was developed and tested in a pilot study and then a validation study, looking at an indoor and outdoor setting with people with multiple sclerosis (PwMS) and a control cohort. Results: In the pilot study, the 95% limits of agreement (LOA) for outdoor tracking in control cohort lay within the a priori defined limit; however, the indoor tracking in both cohorts did not meet the defined limit. The app was then successfully validated outdoors in PwMS. Conclusion: mSteps could be used to accurately measure distance outdoors in PwMS. There is still a need for solutions to accurately and reliably measure distance walked indoors.
From TERF to gender critical: A telling genealogy?
Authors: Thurlow Claire 
Published: September 2022

Over the last 5 years the UK has seen a significant rise in the prominence of trans-exclusionary feminism. What was once termed TERF (trans-exclusionary radical feminism/feminist) is now more often referred to as gender critical feminism/feminist. In this article I argue that this new moniker represents more than a renaming. Instead, it can be interpreted as a rebranding for a present-day where the explicit transphobia of earlier trans-exclusionary feminism is no longer tolerated. I will map two telling changes that I argue currently separates gender critical from TERF, this involves (i) the linguistic pivot from ‘anti-trans’ to ‘pro-woman’ and, (ii) the nascent questioning of the traditional theoretical underpinning of trans-exclusionary feminism. Through this mapping I will explain the rebranding as an attempted claim to legitimacy with an aim of accruing mainstream support. However, exploration of the two changes will show that, despite efforts to obscure the point, gender critical feminism continues to rely on transphobic tropes, moral panics and essentialist understandings of men and women. These factors also continue to link trans-exclusionary feminism to anti-feminist reactionary politics and other ‘anti-gender’ movements.
Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study
Authors: Howell Jessica , Samani Amit , Mannan Binish , Hajiev Saur , Motedayen Aval Leila , Abdelmalak Rebecca , Tam Vincent C. , Bettinger Dominik , Thimme Robert , Taddei Tamar H. , Kaplan David E. , Seidensticker Max , Sharma Rohini 
Published: September 2022

Background: The impact of nonalcoholic fatty liver disease (NAFLD) on overall survival (OS), treatment response and toxicity in patients with hepatocellular carcinoma (HCC) treated with sorafenib is unknown. We examined the impact of NAFLD on survival and toxicity in an international cohort of patients receiving sorafenib. Methods: Clinical and demographic data were collected from patients consecutively treated at specialist centres in Europe and North America. The impact of NAFLD on OS, sorafenib-specific survival and toxicity compared with other aetiologies of liver disease using multivariable Cox-proportional hazards and logistic regression modelling was assessed. Results: A total of 5201 patients received sorafenib; 183 (3.6%) had NAFLD-associated HCC. NAFLD-associated HCC patients were more likely to be older women (median age 65.8 versus 63.0 years, p < 0.01 and 10.4% versus 2.3%, < 0.01), with a median body mass index (BMI) of 29.4. After controlling for known prognostic factors, no difference in OS in patients with or without NAFLD was observed [hazard ratio (HR): 0.99, 95% confidence interval (CI): 0.84–1.18, p = 0.98]. NAFLD-associated patients had more advanced stage HCC when they commenced sorafenib [Barcelona Clinic Liver Class (BCLC) C/D 70.9% versus 58.9%, p < 0.01] and were more likely to be commenced on a lower starting dose of sorafenib (51.4 versus 36.4%, p < 0.01). There was no difference in sorafenib-specific survival between NAFLD and other aetiologies (HR: 0.96, 95% CI: 0.79–1.17, p = 0.96). Adverse events were similar between NAFLD and non-NAFLD HCC groups, including rates of greater than grade 2 hypertension (6.3% versus 5.8%, p = 1.00). Conclusion: Survival in HCC does not appear to be influenced by the presence of NAFLD. NAFLD-associated HCC derive similar clinical benefit from sorafenib compared with other aetiologies.
Sex Differences in Glomerular Protein Expression and Effects of Soy-Based Diet on Podocyte Signaling
Authors: Mahesaniya Afreeda , Williamson Casey R. , Keyvani Chahi Ava , Martin Claire E. , Mitro Alexander E. , Lu Peihua , New Laura A. , Watson Katrina L. , Moorehead Roger A. , Jones Nina 
Published: September 2022

Background: Kidney disease is a major public health issue arising from loss of glomerular podocyte function, and there are considerable sex differences in its prognosis. Evidence suggests a renoprotective effect of estrogen and soy diet-derived phytoestrogens, although the molecular basis for this is poorly understood. Objective: Here, we aim to assess sex differences in expression of key proteins associated with podocyte survival and determine the effects of dietary soy on glomerular and podocyte signaling. Methods: Male and female FVB mice were fed control, low (1%), and high (20%) doses of isolated soy protein (ISP) in utero and until 100 days of age. Spot urine was collected to measure proteinuria and isolated glomeruli were used to quantify activated and total levels of nephrin, Akt, and ERK1/2. To investigate protective effects of specific soy phytoestrogens, cultured podocytes were treated with or without daidzein and subject to control or high glucose as a model of podocyte injury. Results: Nephrin and Akt were elevated at baseline in glomeruli from females compared to males. Both sexes that were fed 1% and 20% ISP displayed robust increases in total glomerular Akt compared to controls, and these effects were more prominent in females. A similar trend at both doses in both sexes was observed with activated Akt and total nephrin. Notably, males exclusively showed increased phosphorylation of nephrin and extracellular signal-regulated kinase (ERK) at the 1% ISP dose; however, no overt changes in urinary albumin excretion or podocin levels were observed, suggesting that the soy diets did not impair podocyte function. Finally, in cultured male and female podocytes, daidzein treatment suppressed high glucose-induced ERK activation. Conclusions: Together, our findings reveal a putative mechanism to explain the protective influence of sex on kidney disease progression, and they provide further evidence to support a beneficial role for dietary soy in preserving glomerular function.
Lack of alternative: Chinese first-time mothers’ construction of social support network of online secondary groups
Authors: Xin Wenjuan 
Published: September 2022

BackgroundAs a result of rapid modernization and the long-term implementation of One Child Policy, Chinese first-time mothers’ primary child-raising social support network is gradually shrinking. At the same time, the social support system for child raising is still very incomplete. Therefore, Chinese first-time mothers generally face great pressure.ObjectiveThis paper aims to understand Chinese first-time mothers’ construction of social support network of online secondary groups.MethodsThis paper employs a qualitative research method, with semi-structured interviews with 23 participants, two focus groups and observations conducted in nine online child-raising communities.ResultsBased on the principle of instrumental rationality first-time mothers use various strategies to join different types of online communities and their online social support network is always the dynamic changing. The online social support network is a supplementary channel in which first-time mothers can obtain both instrumental and emotional support. But communication risks and ethical issues remain, such as information exchange interfered by commercial capital, widespread anxiety and superficial social relationships.ConclusionsOnline social support network is an alternative for Chinese first-time mothers and they urgently need a more well-rounded social support network system with government leading and multiple subjects participating in it.
The effect of a silver hydrogel sheet dressing on postsurgical incision healing after foot and ankle surgery
Authors: Miner Samantha A , Lee Jonathan , Protzman Nicole M , Brigido Stephen A 
Published: September 2022

Introduction Silver hydrogel dressings are antimicrobial dressings with the potential to aid post-surgical healing. The purpose of this study is to evaluate the effects of a silver hydrogel dressing on postoperative scarring and complications. Methods 40 foot and ankle patients (48.43 ± 16.82 years) were included in the study with 20 patients in each group. Postoperatively, the treatment group was treated with a silver hydrogel sheet dressing, and the control group was treated with a standard petroleum-based dressing. Follow-up was performed at two, six, and 12 weeks. Postoperative scarring and complications were evaluated and compared between groups. Scarring was evaluated using the Patient and Observer Scar Assessment Scale (POSAS). Scar length and width were measured using digital calipers and used to compute scar area. Results The treatment group demonstrated statistically significant improvements in the POSAS observer score and observer opinion at six and 12 weeks ( p < 0.001). Additionally, patient reported pain was significantly lower for the treatment group than the control group at 12 weeks ( p < 0.001). Patient reported itch declined across time for both groups ( p < 0.001) with significantly less itching reported by the treatment group ( p = 0.027). Scar area was also significantly lower for the treatment group than the control group at six weeks and 12 weeks ( p ≤ 0.002). Neither group experienced any postoperative complications. Conclusion These results suggest that the inherent properties of the silver hydrogel dressing may improve postsurgical scarring. Lay Summary Surgical incisions result in scar, which can present both cosmetic and rehabilitation concerns after foot or ankle surgery. It is standard to use a petroleum-based dressing on incisions after surgery, however, advancements in incisional dressings have been made over the past 20 years. One such advancement is silver-impregnated hydrogel sheet dressings which have been shown to maintain a moist wound environment conducive to healing, while decreasing the chance of infection through its antimicrobial properties. This paper evaluates scar healing after foot or ankle surgery in patients treated with either the standard petroleum-based dressing, or the silver hydrogel sheet dressing. Patients who were treated with the silver hydrogel dressing had less itching and pain, as well as a smaller scar area than patients in the standard dressing group. Therefore, our results suggest that the silver hydrogel dressing may improve scarring after surgery.