bluuebunny/crossref_metadata_2025_split huggingface dataset:
Australian oncology health professionals’ knowledge, perceptions, and clinical practice related to cancer-related cognitive impairment and utility of a factsheet
Authors: He Sharon , Lim Chloe Yi Shing , Dhillon Haryana M. , Shaw Joanne 
Published: February 2022

Abstract

Purpose

Cancer-related cognitive impairment (CRCI) can have debilitating effects on cancer survivors’ quality of life. Despite this, patients often report a lack of information provided by health professionals (HPs) to assist with understanding and managing cognitive changes. This study aimed to explore Australian oncology HPs’ understanding of and clinical practice related to CRCI including the use of a Cancer Council Australia CRCI factsheet.

Methods
Australian oncology HPs (medical oncologists, cancer nurses, and clinical psychologists) completed a questionnaire that assessed CRCI knowledge, prior to receiving the factsheet. Semi-structured interviews were conducted to explore their perceptions of CRCI and the factsheet. Interviews were recorded, transcribed, and analyzed using framework analysis to identify key themes.

Results
Questionnaires were completed by twenty-nine HPs. Most HPs had moderate to high knowledge of CRCI, yet low knowledge of the relationship between CRCI and cancer. Twenty-six (response rate 90%) HPs; medical oncologists (n = 7), cancer nurses (n = 12), and clinical psychologists (n = 7), consented to be interviewed. Three main themes were identified: (1) Is CRCI impact real or over-rated?; (2) If it is important, they will tell me: identifying and responding to CRCI in clinical practice; and (3) Using a factsheet in clinical practice.

Conclusion
This study’s multi-disciplinary exploration of Australian oncology HPs’ perceptions of CRCI highlighted that health professional perceptions drive CRCI discussions with patients. Further education to support clinicians to discuss CRCI is required. Consideration of the barriers and facilitators within healthcare settings is important for successful integration of the factsheet into routine care.
Multiple solutions for the nonlinear Choquard equation with even or odd nonlinearities
Authors: Cingolani Silvia , Gallo Marco , Tanaka Kazunaga 
Published: February 2022

AbstractWe prove existence of infinitely many solutions $$u \in H^1_r({\mathbb {R}}^N)$$

u
∈

H
r
1

(

R

N

)

for the nonlinear Choquard equation $$\begin{aligned} - {\varDelta } u + \mu u =(I_\alpha *F(u)) f(u) \quad \hbox {in}\ {\mathbb {R}}^N, \end{aligned}$$

-
Δ
u
+
μ
u
=

(

I
α

∗
F

(
u
)

)

f

(
u
)

in

R

N

,

where $$N\ge 3$$

N
≥
3

, $$\alpha \in (0,N)$$

α
∈
(
0
,
N
)

, $$I_\alpha (x) := \frac{{\varGamma }(\frac{N-\alpha }{2})}{{\varGamma }(\frac{\alpha }{2}) \pi ^{N/2} 2^\alpha } \frac{1}{|x|^{N- \alpha }}$$

I
α

(
x
)

:
=

Γ
(

N
-
α

2

)

Γ

(

α
2

)

π

N
/
2

2
α

1

|
x
|

N
-
α

, $$x \in {\mathbb {R}}^N \setminus \{0\}$$

x
∈

R

N

\

{
0
}

is the Riesz potential, and F is an almost optimal subcritical nonlinearity, assumed odd or even. We analyze the two cases: $$\mu $$
μ
is a fixed positive constant or $$\mu $$
μ
is unknown and the $$L^2$$

L
2

-norm of the solution is prescribed, i.e. $$\int _{{\mathbb {R}}^N} |u|^2 =m>0$$

∫

R

N

|
u
|

2

=
m
>
0

. Since the presence of the nonlocality prevents to apply the classical approach, introduced by Berestycki and Lions (Arch Ration Mech Anal 82(4):347–375, 1983), we implement a new construction of multidimensional odd paths, where some estimates for the Riesz potential play an essential role, and we find a nonlocal counterpart of their multiplicity results. In particular we extend the existence results due to Moroz and Van Schaftingen (Trans Am Math Soc 367(9):6557–6579, 2015).
Kleinräumige Verteilung von Gesundheitsbedingungen in Städten
Authors: Spenger David , Geiselhart Klaus 
Published: February 2022

ZusammenfassungDebatten um Umweltgerechtigkeit gehen davon aus, dass ärmere Menschen von höheren gesundheitsrelevanten Umweltbelastungen betroffen sind, als wohlhabende. Untersuchungen in Erlangen zeigen jedoch, dass dies nicht zwangsläufig der Fall ist und nur einzelne sozioökonomisch benachteiligte Gebiete tatsächlich hohen Belastungen ausgeliefert sind. Andere hingegen verfügen durchaus über gute Umweltausstattungen. Zwar lassen sich einzelne besonders privilegierte Gebiete mit geringen Belastungen und guter sozioökonomischer Lage identifizieren aber andere eher wohlhabendere Gegenden zeigen sich als durchaus belastet. Im Zuge neuerer Innenentwicklung gibt es allerdings die Tendenz, dass Umweltressourcen und Umweltbelastungen zunehmend kleinräumiger nach Finanzkraft verteilt werden. Der Artikel entwirft eine leicht übertragbare Methode, die es ermöglicht, anhand der Kernindikatoren Lärmbelastung, Ausstattung mit öffentlichem/privatem Grün und Sozialdaten, Fragen der Umweltgerechtigkeit sehr kleinräumig zu betrachten und im Sinne eines „Frühwarnsystems“ Entwicklungen im Zeitverlauf zu beobachten. Zudem kann der praxisnahe Ansatz als ein Ausgangspunkt für integriertes Verwaltungshandeln gesehen werden, das insbesondere beim Zusammenhang Umwelt und Gesundheit häufig noch defizitär ist.
Taurine supplementation enhances endurance capacity by delaying blood glucose decline during prolonged exercise in rats
Authors: Komine Shoichi , Miyazaki Teruo , Ishikura Keisuke , Matsui Takashi , Miyoshi Takashi , Ra Song-Gyu , Honda Akira , Soya Hideaki , Miyakawa Shumpei , Ohmori Hajime 
Published: February 2022

AbstractTaurine enhances physical performance; however, the underlying mechanism remains unclear. This study examined the effect of taurine on the overtime dynamics of blood glucose concentration (BGC) during endurance exercise in rats. Male F344 rats were subjected to transient treadmill exercise until exhaustion following 3 weeks of taurine supplementation or non-supplementation (TAU and CON groups). Every 10 min during exercise, BGC was measured in blood collected through cannulation of the jugular vein. Gluconeogenesis-, lipolysis-, and fatty acid oxidation-related factors in the plasma, liver, and skeletal muscles were also analyzed after 120-min run. Exercise time to exhaustion was significantly longer with taurine supplementation. BGC in the two groups significantly increased by 40 min and gradually and significantly decreased toward the respective exhaustion point. The decline in BGC from the peak at 40 min was significantly slower in the TAU group. The time when the once-increased BGC regressed to the 0-time level was significantly and positively correlated with exercise time until exhaustion. At the 120-min point, where the difference in BGC between the two groups was most significant, plasma free fatty acid concentration and acetyl-carnitine andN-acetyltaurine concentrations in skeletal muscle were significantly higher in the TAU group, whereas glycogen and glucogenic amino acid concentrations and G6Pase activity in the liver were not different between the two groups. Taurine supplementation enhances endurance capacity by delaying the decrease in BGC toward exhaustion through increases of lipolysis in adipose tissues and fatty acid oxidation in skeletal muscles during endurance exercise.
Efficacy of photobiomodulation in reducing pain and improving the quality of life in patients with idiopathic burning mouth syndrome. A systematic review and meta-analysis
Authors: Camolesi Gisela Cristina Vianna , Marichalar-Mendía Xabier , Padín-Iruegas Maria Elena , Spanemberg Juliana Cassol , López-López Jose , Blanco-Carrión Andrés , Gándara-Vila Pilar , Gallas-Torreira Mercedes , Pérez-Sayáns Mario 
Published: February 2022

AbstractBurning mouth syndrome is a chronic condition, which is characterised by a burning sensation or pain in the mucosa of the oral cavity. Treatment options include antidepressants, antipsychotics, anticonvulsants, analgesics, hormone replacement therapies and more recently photobiomodulation. This study aims to perform a systematic review with meta-analysis in order to determine the effect of photobiomodulation on pain relief and the oral health-related quality of life associated with this condition. A bibliographical search of the Pubmed, Embase, Web of Science and Scopus databases was conducted. Only randomised clinical trials were included. Pain and quality of life were calculated as mean difference and pooled at different treatment points (baseline = T0 and final time point = Tf) and laser modality. From a total of 103 records, 7 articles were retrieved for inclusion. PBM group had a greater decrease in pain than control group at Tf with a mean difference =  − 2.536 (IC 95% − 3.662 to − 1.410; I2 = 85.33%, p < 0.001). An improvement in oral health-related quality of life was observed in both groups, although this was more significant in the photobiomodulation group mean difference =  − 5.148 (IC 95% − 8.576 to − 1.719; I2 = 84.91%, p = 0.003). For the red laser, a greater improvement than infrared was observed, in pain, mean difference =  − 2.498 (IC 95% − 3.942 to − 1.053; I2 = 79.93%, p < 0.001), and in quality of life, mean difference =  − 8.144 (IC 95% − 12.082 to − 4.206; I2 = 64.22%, p = 0.027). Photobiomodulation, in particular, red laser protocols, resulted in improvement in pain and in quality of life of burning mouth syndrome patients.
Response to neoadjuvant chemotherapy and survival in molecular subtypes of resectable gastric cancer: a post hoc analysis of the D1/D2 and CRITICS trials
Authors: Biesma Hedde D. , Soeratram Tanya T. D. , Sikorska Karolina , Caspers Irene A. , van Essen Hendrik F. , Egthuijsen Jacqueline M. P. , Mookhoek Aart , van Laarhoven Hanneke W. M. , van Berge Henegouwen Mark I. , Nordsmark Marianne , van der Peet Donald L. , Warmerdam Fabienne A. R. M. , Geenen Maud M. , Loosveld Olaf J. L. , Portielje Johanneke E. A. , Los Maartje , Heideman Daniëlle A. M. , Meershoek-Klein Kranenbarg Elma , Hartgrink Henk H. , van Sandick Johanna , Verheij Marcel , van de Velde Cornelis J. H. , Cats Annemieke , Ylstra Bauke , van Grieken Nicole C. T. 
Published: February 2022

Abstract
Background
Epstein–Barr virus positivity (EBV+) and microsatellite instability (MSI-high) are positive prognostic factors for survival in resectable gastric cancer (GC). However, benefit of perioperative treatment in patients with MSI-high tumors remains topic of discussion. Here, we present the clinicopathological outcomes of patients with EBV+, MSI-high, and EBV−/MSS GCs who received either surgery only or perioperative treatment.

Methods
EBV and MSI status were determined on tumor samples collected from 447 patients treated with surgery only in the D1/D2 trial, and from 451 patients treated perioperatively in the CRITICS trial. Results were correlated to histopathological response, morphological tumor characteristics, and survival.

Results
In the D1/D2 trial, 5-year cancer-related survival was 65.2% in 47 patients with EBV+, 56.7% in 47 patients with MSI-high, and 47.6% in 353 patients with EBV−/MSS tumors. In the CRITICS trial, 5-year cancer-related survival was 69.8% in 25 patients with EBV+, 51.7% in 27 patients with MSI-high, and 38.6% in 402 patients with EBV−/MSS tumors. Interestingly, all three MSI-high tumors with moderate to complete histopathological response (3/27, 11.1%) had substantial mucinous differentiation. No EBV+ tumors had a mucinous phenotype. 115/402 (28.6%) of EBV−/MSS tumors had moderate to complete histopathological response, of which 23/115 (20.0%) had a mucinous phenotype.

Conclusions
In resectable GC, MSI-high had favorable outcome compared to EBV−/MSS, both in patients treated with surgery only, and in those treated with perioperative chemo(radio)therapy. Substantial histopathological response was restricted to mucinous MSI-high tumors. The mucinous phenotype might be a relevant parameter in future clinical trials for MSI-high patients.
Transcriptomic and Metabolomic Analyses Provide Insights into the Growth and Development Advantages of Triploid Apostichopus japonicus
Authors: Xie Jiahui , Sun Yi , Cao Yue , Han Lingshu , Li Yuanxin , Ding Beichen , Gao Chuang , Hao Pengfei , Jin Xin , Chang Yaqing , Song Jian , Yin Donghong , Ding Jun 
Published: February 2022

AbstractPolyploid breeding is widely used in aquaculture as an important area of new research. We have previously grownApostichopus japonicustriploids with a growth advantage. The body length, body weight, and aestivation time of triploid and diploidA. japonicuswere measured in this study, and the transcriptome and metabolome were used to examine the growth advantage of triploidsA. japonicus. The results showed that the proportion of triploidA. japonicuswith a body length of 6–12 cm and 12–18 cm was significantly higher than that of diploidA. japonicus, and triploidA. japonicushad a shorter aestivation time (39 days) than diploid (63 days). We discovered 3296 differentially expressed genes (DEGs); 13 DEGs (for example,cyclin-dependent kinase 2) related to growth advantage, immune regulation, and energy storage were screened as potential candidates. According to Gene Ontology (GO) enrichment analysis, DEGs were significantly enriched in the cytoplasm (cellular component), ATP binding process (molecular function), oxidation–reduction process (biological process), and other pathways. According to the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment data, DEGs were significantly enriched in ribosome production and other areas. We discovered 414 significant differential metabolites (SDMs), with 11 important SDMs (for example, nocodazole) linked to a growth advantage. SDMs are significantly enriched in metabolic pathways, as well as other pathways, according to the KEGG enrichment results. According to a combined transcriptome and metabolome analysis, 6 DEGs have regulatory relationships with 11 SDMs, which act on 11 metabolic pathways together. Our results further enrich the biological data of triploidA. japonicusand provide useful resources for genetic improvement of this species.
Structure and management of traditional agroforestry vineyards in the high valleys of southern Bolivia
Authors: Oliva Oller Pablo , Notaro Martin , Langer Erick , Gary Christian 
Published: February 2022

AbstractIn the south of Bolivia, a group of traditional wine growers are distinguished by the cultivation of grapevines on native trees that serve as tutors. These growers currently represent one of the few examples of agroforestry vineyards in the world. They offer an opportunity to analyze the structure and management of these cropping systems, and to identify the ecosystem services provided by the combination of grapevines that are trained on trees. We characterize 29 agroforestry vineyards located in three high valleys in southern Bolivia, describing the main farm features, the structure and management of the vineyards, and the advantages of on-tree vine staking as recorded by the farmers. Farms were small (2.2 ha on average), with about half viticulture and half other crops and forage. The workforce was about half family and half employees. The most commonly used tree species were the molle tree (Schinus molle) and chañar tree (Geoffroea decorticans), and the majority of grape varieties grown were landraces such as “Negra criolla” and “Vicchoqueña.” The main cultivation techniques were pruning of the trees and vines, application of manure more than mineral fertilizers, gravity irrigation, and application of few pesticides. The main services farmers expected from trees were protection against climate hazards and flooding, disease control, maintenance of soil fertility, and higher yields. Agroforestry is a promising option for the agroecological transition of viticulture, which deserves further studies at both plot and farm scales.
Bt cotton, pink bollworm, and the political economy of sociobiological obsolescence: insights from Telangana, India
Authors: Najork Katharina , Friedrich Jonathan , Keck Markus 
Published: February 2022

AbstractAfter genetically engineered Bt cotton lost its effectiveness in central and southern Indian states, pink bollworm infestations have recently returned to farmers’ fields and have substantially shifted their vulnerability context. We conceive Bt cotton as a neoliberal technology that is built to protect farmers only temporarily from Lepidopteran pests while ultimately driving the further concentration of capital. Based on data from a representative survey of the three major cotton-producing districts of the state of Telangana (n = 457), we find that pink bollworm pest infestations are a shock to farmers that lead to severe losses in yield and income. Using the vulnerability concept as a framework, we embed our findings in a political-economic context by drawing on Harvey’s notion of accumulation by dispossession. We argue that Bt cotton includes an inherent sociobiological obsolescence that results in a systematic dispossession of resource-poor households while providing appropriation opportunities for other actors. Finally, reproduced hegemonic structures facilitate the accumulation of capital through a redistribution of assets from the bottom to the top of the agricultural sector. Claims that considered Bt cotton as a pro-poor technology were thus flawed from the outset.
Oral-Genital Contact and the Meaning of “Had Sex”: The Role of Social Desirability
Authors: Den Haese Jessica , King Bruce M. 
Published: February 2022

AbstractPrevious studies have found that a large proportion of college students do not consider oral-genital contact as having “had sex.” In all studies, the questions posed were hypothetical. In the present study, university students were asked about their own personal sexual experiences. From a large pool of participants, two subgroups were identified: those who responded “No” to having “had sex” but responded “Yes” to having had oral-genital contact (No–Yes), and those who responded “Yes” to having had both sex and oral-genital contact (Yes–Yes). None of the participants in these two subgroups self-reported vaginal or anal intercourse. The No–Yes group was significantly higher in social desirability (p < .0005) as measured by the Marlowe-Crowne scale and was also significantly higher in religiosity (p < .01) as measured on a 7-point Likert scale. There was a modest correlation between level of religiosity and social desirability (r = .25, p < .01). It was concluded that many students who have had oral-genital contact but deny having had sex do so because of impression management, i.e., a desire to present themselves more positively. These results provide further evidence that social desirability responding is a serious problem for sex researchers, one that affects even the most basic questions about having had sex.
Love in the Time of Corona: Predicting Willingness to Engage in Sexting During the First COVID-19-Related Lockdown
Authors: Thomas Marina F. , Binder Alice , Matthes Jörg 
Published: February 2022

AbstractWhen the COVID-19 pandemic began, in early 2020, lockdowns limited the options for physical intimacy and many resorted to technology-mediated forms of intimacy such as sexting. However, it is unclear what predicted willingness to engage in sexting during the lockdown. The present study filled this gap by investigating COVID-19-related social isolation, privacy concerns, age, and gender as predictors of willingness to engage in sexting. We further examined an interaction of COVID-19-related social isolation and privacy concerns on willingness to engage in sexting. We conducted online surveys with 494 young adults (Study 1) and with a quota-based sample of 437 adults (Study 2) in Austria. In both studies, negative binomial regressions revealed a positive effect of COVID-19-related social isolation on willingness to engage in sexting. Privacy concerns hindered young adults in Study 1 from engaging in sexting but not relatively older adults in Study 2. However, in neither study did privacy concerns moderate the effect of COVID-19-related social isolation on willingness to engage in sexting: Even individuals with high privacy concerns were more willing to sext under conditions of social isolation, suggesting that the need for intimacy outweighed the need for privacy protection. Gender had no effect in either study, indicating that men and women used sexting to cope with the unprecedented COVID-19-related situation.
Adsorption of paper strength additives to hardwood fibres with different surface charges and their effect on paper strength
Authors: Zhao Mengxiao , Robertsén Leif , Wågberg Lars , Pettersson Torbjörn 
Published: February 2022

AbstractLight-weight paper products that contain less fibres, but with a maintained bulk and improved strength properties, are highly desirable due to the low cost of raw materials and improved logistics of packaged goods. In this respect, the adsorption capacity of dry strength additives onto fibres, which is affected by the surface charge of said fibres, is very important for the development of these mechanically robust paper products. The influence of the surface charge on the adsorption of strength additives was investigated for, dissolving grade fibres, kraft fibres and kraft fibres modified with carboxymethyl cellulose (CMC) with different surface charge densities, but the same fibre dimensions. The strength additives investigated were cationic starch (CS), anionic polyacrylamide (APAM) and polyelectrolyte complexes (PECs), containing CS and APAM. A linear relationship was found between the surface charge of the fibres and the saturated adsorbed amount of CS. However, when either APAM or PECs adsorbed as secondary layers onto the CS, no correlation between cellulose charge and the saturation adsorption could be observed. The adsorption of APAM was dramatically affected by the pre-adsorbed amount of CS, whereas PECs were less influenced. Moreover, the additives improved the tensile strength (60%) and strain at break (> 100%) of handsheets formed with the kraft fibres and adsorbed APAM. It was also found that CS/APAM increased the sheet density while CS/PECs lowered it. In conclusion, the gained fundamental understanding of these adsorption of additives is of significant importance to facilitate the industrial development of sustainable low-cost high-end packaging products.Graphical abstract