bluuebunny/crossref_metadata_2025_split huggingface dataset:
O uso de benzodiazepínicos por acadêmicos do curso de Medicina de uma universidade no sul do estado do Tocantins
Authors: Franco Jéssyka Viana Valadares , Sakamoto Agnês Mie , Silva Daniela de Sousa , Braz Dayanna Cristina , Gervásio Flávia Martins , Espíndola Letícia Antunes , Abreu Thamires Monteiro 
Published: July 2022

Os benzodiazepínicos cujas propriedades farmacológicas propiciam ação sedativa, hipnótica, ansiolítica, anticonvulsivante e relaxante muscular são os psicofármacos mais utilizados globalmente potencial para causar dependência química. Objetivou-se analisar o uso de benzodiazepínicos por acadêmicos de um curso de medicina e seus efeitos sistêmicos e sobre o níveis de atenção, ansiedade e desempenho escolar, uma vez que os efeitos sedativos e hipnóticos desta droga são potencializados podendo refletir em ação depressora no Sistema Nervoso Central. Trata-se de uma pesquisa descritiva-exploratória e transversal, no qual foi aplicado questionário eletrônico, sobre o uso de substâncias psicoativas especificamente os benzodiazepínico em acadêmicos matriculados do 1º ao 9º período de medicina de uma faculdade de medicina do sul do Estado do Tocantins, com idade superior a 18 anos, ambos os sexos. Das 126 respostas, 64,3% (81) foram do sexo feminino e 35,7% (45) foram do sexo masculino. Observa-se que que o fármaco mais utilizado é o clonazepam 0,5mg, seguido de alprazolam 0,5mg e em quantidades igual o alprazolam 1mg, e 2mg, clonazepam 2mg e diazepam 5mg e 10mg. A vulnerabilidade dos estudantes em interface ao cenário da saúde mental tem ido cada vez mais ao encontro de perfis ansiosos e depressivos, os quais foram evidenciados no presente estudo. A pesquisa obteve que o uso de benzodiazepínicos por acadêmicos do curso de medicina está associado com a rotina extenuante de estudos e ao volume de requisitos para preparação de um médico, o que evolui para a utilização de medicamentos após o ingresso na faculdade.
Evaluasi Stabilitas dan Penanganan Lereng Produk Aktivitas Vulkanik Kuarter Pada Pembangunan Jalan Baru Shortcut 4 BTS. Kota Singaraja – Mangwitani, Bali
Authors: Sasangka Daru Jaka , Taufik Rakhman , Noor Afriza 
Published: July 2022

Potensi masalah lereng longsor batuan ditemukan pada Pembanguanan jalan baru Shortcut 4 pada ruas jalan nasional Bts. Kota Singaraja – Mangwitani Bali. Potensi Longsoran bersumber pada andesit dengan kekar yang intensif yang dijumpai saat pekerjaan ekskavasi untuk badan jalan dikerjakan. Potensi longsor lereng batu tersebut dapat mengancam bangunan abutmen jembatan yang berada di depannya. Lokasi lereng andesit produk dari intrusi dangkal, berada tepat di tepi danau bratan. Penelitian ini bertujuan untuk menentukan tingkat stabilitas dari lereng berdasarkan masing masing tipe keruntuhannya dan rekomendasi penanganan secara empirik. Metode penelitian berupa pemetaan geologi lokal menentukan jenis batuan, pengukuran dilapangan dengan melakukan scanline lokasi singkapan batuan, menghitung nilai kualitas massa batuan dengan metode Rock Mass Rating (RMR). Penilaian Kualitas Batuan dilakukan dengan metode Rock Mass Rating (RMR) dan evaluasi kestabilan lereng dilakukan dengan Slope Mass Rating (SMR). Tipe potensi longsor yang ada dan dievaluasi antara lain longsor planar memiliki nilai SMR 30,18 (Unstable) dengan kemungkinan longsoran 0,6, Potensi longsor baji memiliki nilai SMR 57,6 (Partialy Stable) dengan kemungkinan longsoran 0,4 dan Potensi longsor jungkiran memiliki nilai SMR 47,6 (Partialy Stable) dengan kemungkinan longsoran 0,4. Nilai SMR menunjukan bahwa lereng batuan memerlukan penanganan atau rekayasa untuk menjadi stabil. Pelandaian sudut lereng menjadi 650 cukup.
Pemberdayaan Media Pemasaran Bagi Kelompok UKM Sagulung Kota Batam
Authors: Rosiska Evan , Lestari Siregar Dian , Raymond Raymond 
Published: July 2022

Kelompok UKM Sagulung yaitu sekelompok pengrajin dan pedagang yang berada di Kelurahan sagulungs Kota Batam. Permasalah dihadapi oleh Kelompok UKM Cemara seperti, rendahnya pemahaman Kelompok UKM Cemara terkait media pemasaran, permasalahan tersebut berdampak pada rendahnya tingkat penjualan produk, rendahnya produktifitas serta perkembangan usaha dari UKM cemara jalan ditempat hasil kegiatan pengabdian kepada masyarakat ini berdampak pada Meningkatnya keahlian dan keterampilan melalui pendampingan dalam memasarkan produk serta meningkatkan pemahaman dalam penggunaan teknologi informasi sehingga mendukung aktifitas penjualan bagi kelompok UKM diSagulung Kota Batam
The Unique Ability of Fine Roots to Reduce Vegetated Coastal Dune Erosion During Wave Collision
Authors: Figlus Jens , Sigren Jacob M. , Feagin Rusty A. , Armitage Anna R. 
Published: July 2022

Vegetated coastal sand dunes can be vital components of flood risk reduction schemes due to their ability to act as an erosive buffer during storm surge and wave attack. However, the effects of plant morphotypes on the wave-induced erosion process are hard to quantify, in part due to the complexity of the coupled hydrodynamic, morphodynamic, and biological processes involved. In this study the effects of four vegetation types on the dune erosion process under wave action was investigated in a wave flume experiment. Sand dune profiles containing real plant arrangements at different growth stages were exposed to irregular waves at water levels producing a collision regime to simulate storm impact. Stepwise multivariate statistical analysis was carried out to determine the relationship of above- and below-ground plant variables to the physical response. Plant variables included, among others, fine root biomass, coarse root biomass, above-ground surface area, stem rotational stiffness, and mycorrhizal colonization. Morphologic variables, among others, included eroded sediment volume, cross-shore area centroid shift, and scarp retreat rate. Results showed that vegetation was able to reduce erosion during a collision regime by up to 37%. Although this reduction was found to be related to both above- and belowground plant structures and their effect on hydrodynamic processes, it was primarily accounted for by the presence of fine root biomass. Fine roots increased the shear strength of the sediment and thus lowered erosional volumes and scarp retreat rates. For each additional 100 mg/L of fine roots (dry) added to the sediment, the erosional volume was reduced by 6.6% and the scarp retreat rate was slowed by 4.6%. Coarse roots and plant-mediated mycorrhizal colonization did not significantly alter these outcomes, nor did the apparent enhancement of wave reflection caused by the fine roots. In summary, fine roots provided a unique ability to bind sediment leading to reduced dune erosion.
Synthesis of Boron-Doped Zinc Oxide Nanosheets by Using Phyllanthus Emblica Leaf Extract: A Sustainable Environmental Applications
Authors: Khalid Awais , Ahmad Pervaiz , Muhammad Saleh , Khan Abdulhameed , Khandaker Mayeen Uddin , Alam Md Mottahir , Asim Mohd , Din Israf Ud , Iqbal Jibran , Rehman Ibad Ur , Razzaq Zohaib , Pandian Sivakumar , Sharma Rohit , Emran Talha Bin , Sayyed M. I. , Aldawood Saad , Sulieman Abdelmoneim 
Published: July 2022

The use of Phyllanthus emblica (gooseberry) leaf extract to synthesize Boron-doped zinc oxide nanosheets (B-doped ZnO-NSs) is deliberated in this article. Scanning electron microscopy (SEM) shows a network of synthesized nanosheets randomly aligned side by side in a B-doped ZnO (15 wt% B) sample. The thickness of B-doped ZnO-NSs is in the range of 20–80 nm. B-doped ZnO-NSs were tested against both gram-positive and gram-negative bacterial strains including Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, and Escherichia coli. Against gram-negative bacterium (K. pneumonia and E. coli), B-doped ZnO displays enhanced antibacterial activity with 26 and 24 mm of inhibition zone, respectively. The mass attenuation coefficient (MAC), linear attenuation coefficient (LAC), mean free path (MFP), half-value layer (HVL), and tenth value layer (TVL) of B-doped ZnO were investigated as aspects linked to radiation shielding. These observations were carried out by using a PTW® electron detector and VARIAN® irradiation with 6 MeV electrons. The results of these experiments can be used to learn more about the radiation shielding properties of B-doped ZnO nanostructures.
Screening ionic liquids for developing advanced immobilization technology for CO2 separation
Authors: Dai Zhengxing , Chen Yifeng , Sun Yunhao , Zuo Zhida , Lu Xiaohua , Ji Xiaoyan 
Published: July 2022

Developing immobilized-ionic liquids (ILs) sorbents is important for CO2 separation, and prior theoretically screening ILs is desirable considering the huge number of ILs. In this study, the compressibility of ILs was proposed as a new and additional index for screening ILs, and the developed predictive theoretical model, i.e., electrolyte perturbed-chain statistical associating fluid theory, was used to predict the properties for a wide variety of ILs in a wide temperature and pressure range to provide systematic data. In screening, firstly, the isothermal compressibilities of 272 ILs were predicted at pressures ranging from 1 to 6,000 bar and temperatures ranging from 298.15 to 323.15 K, and then 30 ILs were initially screened. Subsequently, the CO2 absorption capacities in these 30 ILs at temperatures from 298.15 to 323.15 K and pressures up to 50 bar were predicted, and 7 ILs were identified. In addition, the CO2 desorption enthalpies in these 7 ILs were estimated for further consideration. The performance of one of the screened ILs was verified with the data determined experimentally, evidencing that the screen is reasonable, and the consideration of IL-compressibility is essential when screening ILs for the immobilized-IL sorbents.
Obesity Increases In-Hospital Mortality of Acute Type A Aortic Dissection Patients Undergoing Open Surgical Repair: A Retrospective Study in the Chinese Population
Authors: Pan Xiaogao , Xing Zhenhua , Yang Guifang , Ding Ning , Zhou Yang , Chai Xiangping 
Published: July 2022

ObjectiveThe prevalence of obesity is increasing worldwide, and the role of the obesity paradox in cardiovascular surgery remains controversial. In this study, we redefined obesity according to the Chinese criteria and examined the relationship between obesity and in-hospital mortality in patients with acute type A aortic dissection (AAD) undergoing open surgical repair.Materials and MethodsA total of 289 patients with AAD (between 2014 and 2016) were divided into the non-obese group and obese group for correlation analysis, general information, demographic factors, blood biochemistry, surgical details, and complications, which were used as covariates. Survival was estimated by the Kaplan–Meier method, and any differences in survival were evaluated with a stratified log-rank test. Least Absolute Shrinkage and Selection Operator (LASSO) regression and logistic regression were used to evaluate the effect and interaction of obesity on surgical mortality.ResultsAll the 289 patients had a mean age of 48.64 (IQR 44.00–55.00) and 74.39% were men. Of the 289 patients, 228 were non-obese (78.89%) and 61 were obese (21.11%). Patients with obesity were younger and more prone to unstable blood pressure [systolic blood pressure (SBP) and diastolic blood pressure (DBP)], preoperative hypoxemia and delirium, prolonged operative time, and surgical wound deep infection (p &lt; 0.05). In the fully adjusted model, we observed an increased risk of in-hospital mortality in patients with obesity after fine-tuning other covariates including age and sex (HR = 2.65; 95% CI = 1.03 to 6.80; p = 0.042). The interaction suggested that obesity was more likely to cause death in elderly patients (age ≥ 60), although it was more common in younger patients (test for interaction, p = 0.012).ConclusionObesity, interacting with age, increases the risk of in-hospital mortality in patients with AAD undergoing open surgical repair. Although more verification is needed, we believe these findings provide further evidence for the treatment of AAD.
Spatial and Temporal Distribution Pattern of Oncomelania hupensis Caused by Multiple Environmental Factors Using Ecological Niche Models
Authors: Shi Qianwen , Gong Yanfeng , Zhao Jian , Qin Zhiqiang , Zhang Jun , Wu Jingzhi , Hu Zengyun , Li Shizhu 
Published: July 2022

Objective: This study aimed to predict the spatial and temporal distribution pattern of Oncomelania hupensis (O. hupensis) on a fine scale based on ecological niche models, so as to provide insights into O. hupensis surveillance.Methods: Geographic distribution and environmental variables of O. hupensis in Suzhou City were collected from 2016 to 2020. Five machine learning algorithms were used, including eXtreme gradient boosting (XGB), support vector machine (SVM), random forest (RF), generalized boosted (GBM), and C5.0 algorithms, to predict the distribution of O. hupensis and investigate the relative contribution of each environmental variable. The accuracy of the five ecological niche models was evaluated using the area under the receiver operating characteristic (ROC) curve (AUC) with ten-fold cross-validation.Results: Five models predicted that the potential distribution of O. hupensis was in southwestern areas of Wuzhong, Wujiang, Taichang, and Xiangcheng counties. The AUC of RF, XGB, GBM, SVM, and C5.0 algorithms were 0.8233, 0.8051, 0.7938, 0.7897, and 0.7282, respectively. Comparing the predictive results and the truth of O. hupensis distribution in 2021, XGB and GBM models were shown to be more effective. The six greatest contributors to predicting potential O. hupensis distribution included silt content (13.13%), clay content (10.21%), population density (8.16%), annual accumulated temperatures of ≥0°C (8.12%), night-time lights (7.67%), and average annual precipitation (7.23%).Conclusions: Environmental factors play a key role in the spatial and temporal distribution pattern of O. hupensis. The XGB and GBM machine learning algorithms are effective and highly accurate for fine-scale prediction of potential O. hupensis distribution, which provides insights into the surveillance of O. hupensis.
Tracking Spatio-Temporal Dynamics of Greenhouse-Led Cultivated Land and its Drivers in Shandong Province, China
Authors: Ou Cong , Wang Yongsheng 
Published: July 2022

Rapid urbanization and economic development have led the diversified food production and consumption. In this context, as a highly efficient and intensive cultivated land use form, Greenhouse-led cultivated land (GCL) has continuously increased in recent decades worldwide. Previously works have documented the irrational expansion of GCL in challenging the ecological environment and sustainable agricultural development. However, these studies either have been short-term and point-based studies or have not revealed the long-term causes, process and patterns in a large-scale. In this study, long-term annual remote sensing-based and statistical data were used to investigate the spatiotemporal dynamics of GCL and its drivers in Shandong province, China from 1989 to 2018. The results showed that: 1) GCL in Shandong was toward continuous clustering dominated by medium-low and medium densities, showing the same trend as the increase of its total area; 2) GCL with a cumulative duration of more than 15 years and a demolition frequency of less than 0.2 were mainly distributed in the industrial clustering regions and roughly formed a circular expansion pattern around the central mountainous area with the most expansion period appeared in the mid-2010’s; 3) Budget expenditure for rural development, local retail sales and average earnings of local farmers were the most important local driving factors of the GCL expansion in Shandong. 4) The competition of external vegetable supply and the consumption demand from Beijing were the main external driving forces of the expansion of GCL in Shandong. These findings can enhance the comprehensive understanding of typical component of “Human-Nature” interaction and support the sustainable development of regional agriculture.
A Novel Purine and Uric Metabolism Signature Predicting the Prognosis of Hepatocellular Carcinoma
Authors: Yang Shengjie , Zhang Baoying , Tan Weijuan , Qi Lu , Ma Xiao , Wang Xinghe 
Published: July 2022

Background: Hepatocellular carcinoma (HCC) is regarded as one of the most common cancers in the world with a poor prognosis. Patients with HCC often have abnormal purine and uric acid metabolism, but their relationship with prognosis is unclear.Methods: Here, we collected the data of peripheral blood uric acid and clinical data in 50 patients with HCC and analyzed the relationship with prognosis. At the same time, the transcriptome sequencing data of TCGA and GEO databases were collected to analyze the changes in purine metabolic pathway activity and construct a prognosis prediction model. Based on the prognosis prediction model related to purine metabolism, we further looked for the differences in the immune microenvironment and molecular level and provided possible drug targets.Results: We found that the level of serum uric acid was positively correlated with the prognosis of HCC. At the same time, purine metabolism and purine biosynthesis pathway activities were significantly activated in patients with a poor prognosis of HCC. The prognosis prediction model of HCC based on purine metabolism and purine biosynthesis pathway can accurately evaluate the prognosis of patients with HCC. Meanwhile, we found that there were significant changes in tumor immune infiltration microenvironment and biological function at the molecular level in patients with over-activation of purine metabolism and purine biosynthesis pathway. In addition, we found that uric acid level was positively correlated with peripheral blood leukocytes in HCC patients.Conclusion: In this study, we found that the level of peripheral blood uric acid in patients with HCC is correlated with their prognosis. The prognosis of patients with HCC can be accurately predicted through the metabolic process of uric acid and purine.
Endothelial Function in Postmenopausal Women: The Possible Role of Heat Shock Protein 60 and Serum Androgens
Authors: Armeni Eleni , Soureti Anastasia , Augoulea Areti , Chondrou Asimina , Drakoulis Nikolaos , Kaparos George , Delialis Dimitrios , Stefos Spyros , Angelidakis Lasthenis , Sianis Alexandros , Dimopoulou Aggeliki-Maria , Alexandrou Andreas , Baka Stavroula , Aravantinos Leon , Panoulis Konstantinos , Stamatelopoulos Kimon , Lambrinoudaki Irene 
Published: July 2022

Background: Heat shock protein 60 (HSP60), a potentially homeostatic antigen, is involved in physiological and non-physiological conditions. Experimental data support the role of HSP60 in placental and mitochondrial steroidogenesis. Furthermore, HSP60 is translocated into the endothelial-cell plasma membrane and the extracellular space under stress conditions, promoting the atherosclerotic process. Therefore, we investigated the association between HSP60 and endothelial function in postmenopausal women, considering the possible atherogenic effect of androgenic hormones.Methods: This study included 123 healthy postmenopausal women. Exclusion criteria were treated hypertension or dyslipidaemia, menopause hormone therapy during the last 6 months, and previously diagnosed peripheral vascular disease or cardiovascular disease. Fasting venous blood samples were obtained for biochemical and hormonal assessment and evaluation of HSP60. Sonographic assessment of flow-mediated dilation (FMD) occurred immediately after that in one session.Results: Univariate analysis showed that women with FMD values below median 5.12% had lower logHSP60 values (low vs. high FMD, HSP60 values: 2.01 ± 1.16 ng/ml vs. 3.22 ± 1.17 ng/ml, p-value = 0.031). Multivariable analysis showed that logHSP60 was associated with FMD (b-coefficient = 0.171, p-value = 0.046), adjusting for traditional cardiovascular risk factors (TRFs) and insulin levels. Further adjustment for testosterone and DHEAS rendered the result non-significant. In the multivariable analysis, FMD was associated with insulin (b-coefficient = −0.166, p-value = 0.034), testosterone (b-coefficient = −0.165, p-value = 0.034), DHEAS (b-coefficient = −0.187, p-value = 0.017), adjusting for TRFs.Discussion: The results of this study indicate that the association between androgens and endothelial function is possibly mediated by HSP60 molecules, in women with low insulin resistance and androgenicity. Further prospective studies are needed to explore the significance of our findings.
Non-Invasive Prediction Models for Esophageal Varices and Red Signs in Patients With Hepatitis B Virus-Related Liver Cirrhosis
Authors: Liang Huixin , Si Hang , Liu Mingzhu , Yuan Lianxiong , Ma Ruiying , Zhang Genglin , Yang Jianrong , Mo Zhishuo , Zhao Qiyi 
Published: July 2022

Background: Red signs are closely related to esophageal variceal bleeding, and, despite improvements in therapy, the mortality rate remains high. We aimed to identify non-invasive predictors of esophageal varices and red signs in patients with hepatitis B virus-related liver cirrhosis.Methods: This retrospective study included 356 patients with hepatitis B virus-related liver cirrhosis after applying inclusion and exclusion criteria among 661 patients. All patients underwent endoscopy, ultrasonography, laboratory examinations, and computed tomography/magnetic resonance imaging. Univariate and multivariate logistic regression analysis were performed, and prediction models for esophageal varices and red signs were constructed.Results: Multivariate analysis revealed that spleen diameter, splenic vein diameter, and lymphocyte ratio were independent risk factors for esophageal varices and red signs. On this basis, we proposed two models: i) a spleen diameter-splenic vein diameter-lymphocyte ratio-esophageal varices prediction model (SSL-EV model); and ii) a spleen diameter-splenic vein diameter-lymphocyte ratio-red sign prediction model (SSL-RS model). The areas under the receiver operating characteristic curve for the two prediction models were 0.843 and 0.783, respectively. With a cutoff value of 1.55, the first prediction model had 81.3% sensitivity and 76.1% specificity for esophageal varices prediction. With a cutoff value of −0.20, the second prediction model had 72.1% sensitivity and 70.7% specificity for the prediction of red signs.Conclusions: We proposed a new statistical model, the spleen diameter-splenic vein diameter-lymphocyte ratio-red sign prediction model (SSL-RS model), to predict the presence of red signs non-invasively. Combined with the spleen diameter-splenic vein diameter-lymphocyte ratio-esophageal varices prediction model (SSL-EV model), these non-invasive prediction models will be helpful in guiding clinical decision-making and preventing the occurrence of esophageal variceal bleeding.