bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitating national football teams return to training and competition during the COVID-19 pandemic
Authors: Guard Andrew , Brenneman Anne , Bradley Matt , Chiampas George T 
Published: April 2022

ObjectivesProvide a robust framework to provide a safe environment for return to training and competition of the US national soccer teams following domestic and international travel.MethodsUS Soccer COVID-19 working group created a return to play manual for its national teams, prescribing discrete phases to return to training and competition. This was underpinned by strict health and safety and travel protocols for specific venues and persons. This was complemented by an aggressive testing cadence and isolation policies for delegations (players, internal and external support staff). Between September 2020 and April 2021, there were nine events for males and females at the youth, senior and Paralympic level, with international opponents hosted domestically.ResultsIn total, 6590 point of care (POC) (n=1810) and PCR (n=4780) tests combined were run. Overall positivity rate for players and staff in male events of 0.10% (n=2) and 0.00% (n=0) for females were recorded. Staff positivity rate was 0.14% overall, and external vendors 0.10%. Total POC and PCR positives in male events (n=2) occurred either the day of arrival or the following day.ConclusionThe implementation of strictly adhered to protocols and testing cadences yielded low positivity rates within team delegations. By comparison, initial league-wide COVID-19 testing in mid-2020 in other sports reported league-wide positivity rates of 2.9% (National Football League), 2.7% (Major League Soccer) and 5.3% (National Basketball Association). The English Premier League reported an increase in positivity rate in early 2021 from 1.22% to 1.74%.With the implementation of regimented protocols and stringent testing, it is possible to hold elite-level international sporting competitions involving long-haul travel while ensuring continued safety during a global pandemic.
Clinical outcomes in spontaneous coronary artery dissection
Authors: Garcia-Guimaraes Marcos , Masotti Monica , Sanz-Ruiz Ricardo , Macaya Fernando , Roura Gerard , Nogales Juan Manuel , Tizón-Marcos Helena , Velázquez-Martin Maite , Veiga Gabriela , Flores-Ríos Xacobe , Abdul-Jawad Altisent Omar , Jimenez-Kockar Marcelo , Camacho-Freire Santiago , Moreu Jose , Ojeda Soledad , Santos-Martinez Sandra , Sanz-Garcia Ancor , del Val David , Bastante Teresa , Alfonso Fernando 
Published: April 2022

ObjectiveSpontaneous coronary artery dissection (SCAD) is an infrequent cause of acute coronary syndrome. Our aim was to assess adverse events at follow-up from a nationwide prospective cohort.MethodsThe Spanish Registry on SCAD (SR-SCAD) included patients from 34 hospitals. All coronary angiograms were analysed by two experts. Those cases with doubts regarding the diagnosis of SCAD were excluded. The angiographic SCAD classification by Sawet alwas followed. Major adverse cardiovascular and cerebrovascular event (MACCE) was predefined as composite of death, myocardial infarction, unplanned revascularisation, SCAD recurrence or stroke. All events were assigned by a Clinical Events Committee.ResultsAfter corelab evaluation, 389 patients were included. Most patients were women (88%); median age 53 years (IQR 47–60). Most patients presented as non-ST-segment-elevation myocardial infarction (54%). A type 2 intramural haematoma (IMH) was the most frequent angiographic pattern (61%). A conservative initial management was selected in 78% of patients. At a median time of follow-up of 29 months (IQR 17–38), 46 patients (13%) presented MACCE, mainly driven by reinfarctions (7.6%) and unplanned revascularisations (6.2%). Previous history of hypothyroidism (HR 3.79; p<0.001), proximal vessel involvement (HR 2.69; p=0.009), type 2 IMH (HR 2.12; p=0.037) and dual antiplatelet therapy (DAPT) at discharge (HR 2.18; p=0.042) were independent predictors of MACCE.ConclusionsIn this large prospective cohort of patients with SCAD, prognosis was overall favourable, with events mainly driven by reinfarctions or unplanned revascularisations. History of hypothyroidism, proximal vessel involvement, type 2 IMH and DAPT at discharge were associated with MACCE.Trial registration numberNCT03607981.
Thinning to meet sawlog objectives at shorter rotation in lodgepole pine stands
Authors: Hossain Kazi L. , Lieffers Victor J. , Pinno Bradley D. 
Published: April 2022

We modelled how pre-commercial and commercial thinning affects development of merchantable timber, specifically large sawlogs (>20 cm diameter), on various site qualities and at different harvest ages. Data from juvenile permanent sample plots from post-harvest regenerated lodgepole pine stands in Alberta were projected using the Mixedwood Growth Model (MGM 21). Pre-commercial thinning (PCT) and different levels of commercial thinning (CT) with PCT were assessed on stands of good, medium, and fair site quality. Results show site quality alone had the greatest impact on merchantable yields with good sites producing ∼1.5 times the yield of medium and ∼4.3 times that of the fair sites. Moderate thinning on good sites produced a greater quantity of large sawlogs (>20 cm diameter) and their associated volume over unthinned stands than that on medium or fair sites, though thinning positively influenced total yield on these sites as well. On good sites, at age 50, CT treatments produced about ∼50 m3/ha more volume of large sawlogs (>20 cm) than the control; such gain drops to 18 m3/ha on medium sites. In addition, the mean annual increment culminated earlier on good sites, also enabling earlier harvest.
On free fall of quantum matter
Authors: Emelyanov Viacheslav A. 
Published: April 2022

AbstractWe propose an approach that allows to systematically take into account gravity in quantum particle physics. It is based on quantum field theory and the general principle of relativity. These are used to build a model for quantum particles in curved spacetime. We compute by its means a deviation from a classical geodesic in the Earth’s gravitational field. This shows that free fall depends on quantum- matter properties. Specifically, we find that the free-fall universality and the wave-packet spreading are mutually exclusive phenomena. We then estimate the Eötvös parameter for a pair of atoms freely falling near the Earth’s surface, provided that the wave-packet spreading is more fundamental than the weak equivalence principle.
Psychometric Evaluation of the Disabilities of the Arm, Shoulder and Hand Outcome Questionnaire for Brachial Plexus Injury Using Rasch Analysis
Authors: DOI Kazuteru , SEM Sei Haw , HATTORI Yasunori , SAKAMOTO Sotetsu , HAYASHI Kota 
Published: April 2022

Background: Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire is the most widely used patient-reported outcome measure (PROM) for assessment of upper extremity disability assessment. However, DASH is a multidimensional measurement with different difficulty levels and ratio apportionment of the items categorised by ordinal scale. This has caused a misinterpretation of the total disability scores. We created a modified DASH adapted to the Rasch model. The aim of this study is to compare the functional recovery and quality of life (QOL) improvement and to assess the validity of the original DASH and modified DASH between C56/C567, C5-8 and total types of brachial plexus injury (BPI) following surgical reconstruction. Methods: A total of 183 BPI patients who underwent reconstructive surgery were evaluated for functional recovery using the range of motion and power of the affected limb, and improvement in QOL with DASH. The collected data were analysed using Rasch measurement theory to detect the misfit items. The original and modified DASH were compared under the three different types of BPI after item reduction by removing the misfit items. Results: There were significant differences in functional recovery between three types of palsy. However, PROM using DASH score with or without misfit items (12 items) did not show any significant differences. Conclusions: DASH is not suitable for comparison of upper extremity disabilities even after being corrected mathematically due to the inclusion of items from many different domains unequally. Therefore, each item of the function (with or without compensation of the uninjured hand), pain and impact to the patients should be evaluated separately. Level of Evidence: Level IV (Prognostic)
Outcomes of Unconstrained Proximal Interphalangeal Joint Arthroplasty: A Systematic Review
Authors: KULKARNI Kunal , SHEIKH Nomaan , AUJLA Randeep , DIVALL Pip , DIAS Joseph 
Published: April 2022

Background: Unconstrained pyrocarbon and metal-on-polyethylene (MoP) proximal interphalangeal (PIP) joint arthroplasty is an increasingly popular alternative to silicone implants and arthrodesis. This systematic review appraises their outcomes. Methods: Thirty studies comprising 1,324 joints (813 pyrocarbon, 511 MoP) were included. Mean patient age was 59 years (38–78) and mean follow-up period was 54 months (12–118). Results: There were mean improvements of 4.5 points (2–6.9) in pain visual analogue score, 10.5° (−26 to 58) in range of motion (ROM), 3.1 kg (−4 to 7) in grip strength, 0.6 kg (−1.5 to 2) in pinch strength and 18 points (−3 to 29) in the disabilities of the arm, shoulder and hand score, with no significant differences between implant types. ROM gains deteriorated over time. Clinical complications were frequent (23%) and significantly more common with pyrocarbon, as were radiographic complications. However, most were mild-moderate and did not necessarily correlate with negative outcomes or dissatisfaction. Overall re-operation rate was 21%, and revision rate 11%, both more frequent with pyrocarbon. Most revisions were within 24 months, beyond which survival was maintained up to 10 years. Conclusions: Unconstrained PIP joint arthroplasty is effective in improving pain scores, active ROM, grip/pinch strength and patient-reported outcome measures, particularly in patients with osteoarthritis. Results are generally maintained at least to the medium term, although gains diminish in the longer term. Complication and early revision rates are high, particularly with pyrocarbon implants. Most patients express positive attitudes to arthroplasty, with significant improvements in patient-reported outcome measures for both pyrocarbon and MoP implants. Patients with post-traumatic and inflammatory arthropathy are generally less satisfied. There is currently insufficient data to recommend one implant type over another, although the early-to-medium term results of MoP implants are promising. Prospective surveillance via small joint registries is recommended. Level of Evidence: Level III (Therapeutic)
Outcomes of Rerouting the Palmaris Longus to Extensor Pollicis Longus Tendon Transfer through the Second Extensor Compartment for Radial Nerve Palsy
Authors: TANAKA Yoshitaka , GOTANI Hiroyuki , SASAKI Kosuke , YAGI Hirohisa , MATSUGAKI Toru 
Published: April 2022

Background: A palmaris longus (PL) to extensor pollicis longus (EPL) is a standard tendon transfer used to restore thumb extension in patients with radial nerve palsy. This transfer is done by withdrawing the EPL from the third compartment and passing it subcutaneously to reach the PL. We modified this transfer by rerouting the EPL through the second extensor compartment to improve the retropulsion of the thumb. The aim of this study is to report the outcomes of this modified transfer. Methods: Four patients with traumatic radial nerve palsy underwent the modified PL to EPL transfer. They also underwent transfer of the pronator teres (PT) to extensor carpi radialis brevis (ECRB) and flexor carpi radialis (FCR) to extensor digitorum communis (EDC). Patients were followed up for at least 1 year after surgery. The data with regard to age, gender, cause of radial nerve palsy, duration between injury and surgery, and duration of follow-up was recorded. At final follow-up, the arc of motion at the interphalangeal joint (IPJ), metacarpophalangeal joint (MCPJ), palmar and radial abduction and retropulsion were measured for the reconstructed thumb and contralateral normal thumb. Results: All patients were male, with a mean age of 34.3 (range, 19–46) years. The mean duration between the injury and surgery was 15.9 (7–27) months, and the mean post-operative follow-up period was 16.8 (12–25) months. All patients recovered good thumb function. The mean arc of motion of the affected and contralateral thumb were IPJ flexion: 52°/80°; IPJ extension: 21°/14°; MCPJ flexion: 30°/33°; MCPJ extension:24°/31°; radial abduction: 70°/74°; palmar abduction: 68°/75° and retropulsion: 4.8cm/5.0cm. Conclusion: Rerouting the PL to EPL tendon transfer through the second extensor compartment in radial nerve palsy can restore good thumb function especially retropulsion. Level of Evidence: Level IV (Therapeutic)
A Review of Outcome Reporting Practices after Flexor Tendon Repair in Zones 1 and 2
Authors: MALLINA Ravi , BAMFORD Emma , SHELTON Ian , SELBY Anna , RUSSELL Peter , JOHNSON Nick 
Published: April 2022

Background: Outcome reporting following flexor tendon repair has historically concentrated on range of movement. Recently, there has been an increase in the use of patient-reported outcome measures (PROMs). At present, there is no agreed set of outcomes to report following flexor tendon repair. The aim of this study is to review outcome reporting practices after flexor tendon repair in zones 1 and 2. Methods: A search of Ovid MEDLINE, Ovid EMBASE and Cumulative Index to Nursing and Allied Health Literature (CINAHL) between 1 January 1980 and 31 December 2019 was performed to identify the studies that reported outcomes following the repair of flexor tendons in zones 1 and 2. Study characteristics and data with regard to the reporting of eight outcome domains was extracted: functional outcome (quantitative), functional outcome (subjective), activities of daily living (ADL), satisfaction/quality of life, post-treatment recovery, resources, aesthetics and safety. Results: A total of 94 out of 4,118 articles identified were included in the review. All studies reported range of motion using 17 different methods of measurement. Eleven studies defined measurement methods incorrectly or unclearly. Only 16 studies reported PROMs, with only one reporting data on assessment of quality of life. Eighteen studies reported time away from employment. Minimal data on resource utilisation and aesthetics were included. Conclusion: This review highlights wide heterogeneity and paucity of data reporting clinical outcomes of flexor tendon surgery. The development of a core outcome set that would ensure essential outcomes are correctly defined, measured and reported is required. Level of Evidence: Level IV (Prognostic)
The Impact of COVID-19 on the Choice of Treatment for Hand Fractures: A Single-Centre Concordance Study
Authors: ROJOA Djamila M. , RAHEMAN Firas J. , IRVINE Esmee , SHARMA Vivek , MACDONALD Christopher R. , CUTLER Lucy 
Published: April 2022

Background: Management of hand trauma has evolved to incorporate assessment, treatment and rehabilitation of patients in a ‘one-stop’ clinic on initial presentation. Our aim was to evaluate the effect of coronavirus disease 2019 (COVID-19) on the choice of treatment for hand fractures using inter-rater agreement between surgeons. Methods: All patients with hand fractures during the COVID-19 lockdown from March to May 2020 were included in the study. Two experienced hand surgeons blinded to management and outcomes independently reviewed radiographic images and relevant clinical history to provide their opinion on optimal treatment. Weighted kappa analysis was performed to determine concordance and inter-rater agreement between the two surgeons and actual management. Results: The study included 82 patients (62 men and 20 women) with a mean age of 40.3 (SD 19.7). The injuries occurred most often at home following an accident (34%) or a fall (28%). Fractures involved the metacarpals in 29 patients and the distal phalanx in 22 patients. Thirty-five patients underwent surgery, whereas 47 were managed conservatively. Overall agreement between actual management and consultant A and consultant B was moderate (κ = 0.55, p < 0.0001 and κ = 0.63, p < 0.0001, respectively). Subgroup analysis showed a weak agreement between actual management of metacarpal fractures and consultant A and consultant B (κ = 0.22, p = 0.29 and κ = 0.47, p = 0.02, respectively). Inter-rater agreement was substantial for management of metacarpal fractures (κ = 0.73, p < 0.0001), but weak for distal phalanx fractures (κ = 0.29, p = 0.03). Conclusion: Our study has shown that overall management of hand fractures remained optimised throughout the pandemic. However, a lack of concordance was observed in the management of metacarpals. Level of Evidence: Level IV (Therapeutic)
Is Repair of a Small Coronoid Fracture Required in the Surgical Treatment of Terrible Triad Injury of the Elbow?
Authors: KANESHIRO Yasunori , YANO Koichi , YOKOI Takuya , SAKANAKA Hideki , FUKUDA Makoto , HIDAKA Noriaki 
Published: April 2022

Background: Multiple treatment protocols have been described in literature for the treatment of terrible triad injury (TTI) of the elbow. We believe that repair of the medial collateral ligament (MCL) should be performed in preference to repair of a small coronoid fracture if the elbow is unstable after fixation/replacement of the radial head and repair of the lateral collateral ligament (LCL). The aim of this study is to report the outcomes of surgical treatment of patients with TTI associated with a small coronoid fracture in whom the coronoid fracture was not addressed. Methods: This study is a retrospective case series of 12 consecutive patients who underwent surgery for acute TTI with a small coronoid fracture (9 Regan–Morrey type I and 3 Regan–Morrey type II). Ten patients had complete MCL injuries. All patients underwent repair of the torn LCL and MCL and treatment of the radial head. The coronoid fracture was not surgically treated. At the final follow-up, the range of motion, degree of flexion contracture, Mayo elbow performance score (MEPS) and Disabilities of the Arm, Shoulder and Hand (DASH) were measured. Results: The mean follow-up period was 13.5 months. At the final follow-up, the mean arc of elbow flexion was 132° and the mean flexion contracture was 10°. The mean arc of forearm rotation was 148°. None of the patients demonstrated elbow instability. The mean MEPS was 92.5 points with seven having excellent results and five having good results. The average DASH score was 11.2 points. Conclusions: Our results showed that good elbow stability, arc of motion and clinical outcomes could be achieved without repair of small coronoid fractures in the treatment of TTI. The repair of MCL injuries should be given priority over the fixation of small coronoid fractures to regain elbow stability. Level of Evidence: Level IV (Therapeutic)
Factors Influencing the Risk of Major Amputation in Patients with Diabetic Foot Ulcers Treated by Autologous Cell Therapy
Authors: Husakova J. , Bem R. , Fejfarova V. , Jirkovska A. , Woskova V. , Jarosikova R. , Lovasova V. , Jude E. B. , Dubsky M. 
Published: April 2022

Introduction. Autologous cell therapy (ACT) is one of the last options for limb salvage in patients with chronic limb-threatening ischemia (CLTI) and diabetic foot ulcers (DFU). However, some patients may still undergo a major amputation even after ACT, but the risk factors for this are not known. Therefore, the aim of our study was to assess the risk factors for major amputation in patients with CLTI and DFU during a 2-year follow-up after ACT. Methods. One hundred and thirteen patients after ACT were included in our study and divided into two groups: Group 1 with major amputation (AMP;

n
=
37

) and Group 2 without amputation (nAMP,

n
=
76

). The risk factors for major amputation were evaluated before ACT and included factors relating to the patient, the DFU, and the cell product. Results. The AMP group had significantly higher C-reactive protein (CRP) levels compared to the nAMP group (22.7 vs. 10.7 mg/L,

p
=
0.024

). In stepwise logistic regression, independent predictors for major amputation were mutation of the gene for methylenetetrahydrofolate reductase (MTHFR) with heterozygote and homozygote polymorphism 1298 (OR 4.33 [95% CI 1.05-17.6]), smoking (OR 3.83 [95% CI 1.18-12.5]), and

CRP
>
10

mg
/
L

(OR 2.76 [95% CI 0.93-8.21]). Lower transcutaneous oxygen pressure (TcPO2) values were observed in AMP patients compared to the nAMP group at one month (24.5 vs. 33.2,

p
=
0.012

) and at 3 months (31.1 vs. 40.9,

p
=
0.009

) after ACT. Conclusion. Our study showed that the risk for major amputation after ACT in patients with CLTI and DFU is increased by the presence of MTHFR heterozygote and homozygote gene mutations, smoking, and higher CRP at baseline. Lower TcPO2 at one and 3 months after ACT may also have a predictive value. Therefore, it is necessary to stop smoking before ACT, treat any infection, and, above all, consider antiaggregation or anticoagulant treatment after the procedure.
Photoacoustic Tomography Detects Response and Resistance to Bevacizumab in Breast Cancer Mouse Models
Authors: Quiros-Gonzalez Isabel , Tomaszewski Michal R. , Golinska Monika A. , Brown Emma , Ansel-Bollepalli Laura , Hacker Lina , Couturier Dominique-Laurent , Sainz Rosa M. , Bohndiek Sarah E. 
Published: April 2022

Abstract

Angiogenesis is an established prognostic factor in advanced breast cancer, yet response to antiangiogenic therapies in this disease remains highly variable. Noninvasive imaging biomarkers could help identify patients that will benefit from antiangiogenic therapy and provide an ideal tool for longitudinal monitoring, enabling dosing regimens to be altered with real-time feedback. Photoacoustic tomography (PAT) is an emerging imaging modality that provides a direct readout of tumor hemoglobin concentration and oxygenation. We hypothesized that PAT could be used in the longitudinal setting to provide an early indication of response or resistance to antiangiogenic therapy. To test this hypothesis, PAT was performed over time in estrogen receptor–positive and estrogen receptor–negative breast cancer xenograft mouse models undergoing treatment with the antiangiogenic bevacizumab as a single agent. The cohort of treated tumors, which were mostly resistant to the treatment, contained a subset that demonstrated a clear survival benefit. At endpoint, the PAT data from the responding subset showed significantly lower oxygenation and higher hemoglobin content compared with both resistant and control tumors. Longitudinal analysis revealed that tumor oxygenation diverged significantly in the responding subset, identifying early treatment response and the evolution of different vascular phenotypes between the subsets. Responding tumors were characterized by a more angiogenic phenotype when analyzed with IHC, displaying higher vessel density, yet poorer vascular maturity and elevated hypoxia. Taken together, our findings indicate that PAT shows promise in providing an early indication of response or resistance to antiangiogenic therapy.

Significance:
Photoacoustic assessment of tumor oxygenation is a noninvasive early indicator of response to bevacizumab therapy, clearly distinguishing between control, responding, and resistant tumors within just a few weeks of treatment.