bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polygenic analysis of genetic susceptibility to essential hypertension
Authors: Timasheva Y. R. , Gerasimova K. A. , Tuktarova I. A. , Erdman V. V. , Nasibullin T. R. 
Published: May 2022

Objective. To investigate the molecular mechanism underlying genetic susceptibility to essential hypertension (EH) using polygenic analysis of renin-angiotensin-aldosterone system (RAAS).Design and methods.Genotyping of renin (REN, rs2368564), angiotensinogen (AGT, rs4762), angiotensin II receptor type 1 (AGTR1, rs5186), chymase 1 (CMA1, rs1800875) and angiotensin-converting enzyme (ACE, rs1799752) polymorphic variants was performed in 346 patients with EH and 377 controls, Russians and Tatars by ethnic origin.Results. ACE rs1799752polymorphism was significantly associated with EH risk in Tatars (PBonf= 0,003) and in the total study group (PBonf= 4,09 x 10–5). Polygenic approach identified 12 genotypes and/or alleles combinations of RAAS genes polymorphisms, significantly associated with EH in the Tatars, and 6 patterns associated with EH in the total study group. The highest risk of disease in Tatar men was associated with REN rs2368564*T + AGTR1 rs5186*C/A + ACE rs1799752*D combination (OR = 16,64, PBonf= 0,001), in the total group — with REN rs2368564*T/C + CMA1 rs1800875*G combination (OR = 2,37, PBonf= 0,045).Conclusions. Our findings indicate that EH risk in men of Russian and Tatar ethnicity is significantly associated with ACE rs1799752 polymorphism, and the results of polygenic analysis demonstrate an association of the disease risk with genotype/allele combinations of polymorphic variants in REN (rs2368564), AGTR1 (rs5186), ACE (rs1799752), and CMA1 (rs1800875) genes.
Cardiometabolic risk factors and renin-angiotensin system polymorphisms in young individuals with various metabolic phenotypes
Authors: Chulkov V. S. , Gavrilova E. S. , Chulkov V. S. , Pankova E. D. , Martynov S. A. , Manzhos V. I. 
Published: May 2022

Background. The increased prevalence of obesity and associated cardiometabolic diseases attract attention worldwide. Renin-angiotensin system can link obesity and cardiovascular and metabolic diseases.Objective. To access a comprehensive assessment of cardiometabolic risk factors and gene polymorphisms of the renin-angiotensin system in metabolic phenotypes among young individuals.Design and methods.The sample consisted of 251 individuals, who were divided into four groups: group 1 — metabolically healthy individuals with normal body mass index (BMI) (n = 62); group 2 — metabolically unhealthy individuals with normal BMI (n = 57); group 3 — metabolically healthy overweight/obese individuals (n = 16); group 4— metabolically unhealthy overweight/ obese individuals (n = 116). All participants answered a questionnaire designed for this study. Anthropometric, clinical and biochemical parameters were assessed. The following polymorphisms were evaluated:, A1166C polymorphism of the angiotensin II type 1 receptor gene (rs5186), M235T polymorphism of the angiotensinogen gene (rs699), T174M polymorphism of the angiotensinogen gene (rs4762), I/D polymorphism of the angiotensinconverting enzyme gene (rs4340).Results. In young individuals with metabolically unhealthy overweight/ obesity, a higher frequency of coexistent abdominal obesity and hypertension was found in combination with a higher frequency of the allele T of AGT 235M/T. The greater differences in carbohydrate and lipid metabolism in combination with a higher serum levels of leptin and low serum concentrations of adiponectin were also found in young individuals with metabolically unhealthy overweight/obesity.
Association of plasma folic acid levels with parameters of glutathione metabolism in hypertensive patients with comorbid diseases
Authors: Alexandrova L. A. , Subbotina T. F. , Ionova Zh. I. , Berkovich O. A. , Zhloba A. A. 
Published: May 2022

Objective. Hypertension (HTN) is characterized by a high incidence of comorbidity. An individual approach to the management of such patientsrequires new markers for differential diagnosis. The pathophysiology of most comorbidities is closely related to endothelial dysfunction triggered by an imbalance in redox processes.The aim of this work is to assess the relationship between plasma level of folic acid (FA) and the state of the redox system of erythrocyte glutathione in patients with HTN and concomitant target organ damage in cardiovascular diseases (HTN + CVD), chronic kidney disease (HTN + CKD) and discirculatory encephalopathy (HTN + DE).Design and methods. We enrolled 93 patients with HTN admitted to the clinics of the Pavlov University, and 30 donors of the reference group. We assessed plasma concentration of folic acid, the content of reduced glutathione (GSH) and the activity of glutathione reductase (GR) in erythrocytes.Results. In HTN patients with the deficiency of FA, a lower content of GSH and activity of GR in erythrocytes were found compared to the HTN patients without deficiency and the reference group. In the groups HTN + CVD and HTN + DE, the GSH level and GR activity correlated with the plasma concentration of FA and were lower in the subgroups with FA deficiency. In subgroups with normal FA content, these parameters did not differ from the reference indicators.Conclusions. The parameters of GSH and GR in patients with HTN + CVD and HTN + DE, but not HTN + CKD, can be considered as potential markers of functional FA deficiency.
Improving students’ cricket hitting skills using digital test
Authors: Padli Padli , Mardela Romi , Yendrizal Yendrizal 
Published: May 2022

This study aims to find out the level of students’ hitting skills and student responses after using ball-hitting skills. This type of research is a mixed method with an explanatory model. The sampling technique used was purposive sampling with a sample of 30 students who were active and contracted in the cricket courses. Before collecting data, the researcher tested the instrument using reliability and validity tests. Then, data analysis was conducted using quantitative data analysis in the form of linear regression and qualitative data analysis used Miles and Huberman’s method. The findings obtained in the field show that students have the skill to hit the ball and respond well. Other findings also show that there is an effect of student responses to the observations made. This means that there is an influence of the tools used on students’ ball-hitting skills.
Keywords: Student hitting skills, ball-hitting skill gauge, cricket.
The impact of the shift to distance learning on the seven principles of good practices in university education in light of the COVID-19 pandemic
Authors: Ahmad Baniomar Khitam 
Published: May 2022

Abstract
This study aimed to know the level of impact of the shift to distance learning on the seven principles of good practices in university education taking the novel coronavirus COVID-19 pandemic into consideration from the viewpoint of students of faculties of education. The research method used for this study was descriptive, a well structured questionnaire was developed for this, which was then administered to 435 students. The results revealed that the level of impact of the shift to distance learning on these principles taking the COVID-19 pandemic into consideration from the standpoint of the students was average. The study also revealed that the impact of the transition to distance learning on these principles, taking the COVID-19 pandemic into consideration due to the variables of academic level, appreciation, devices used in distance learning and software used in distance learning, and that there are differences due to the variable type of university in favour of public universities, was not statistically significant. The study recommendations, most notably the development of a national strategy for the development of distance learning to maintain its sustainability after the end of the corona pandemic.
Keywords: Distance learning, good practices, university education, coronavirus (covid-19) pandemic.
Estimation of the Size and Type of Porosity in an Albian Carbonate Reservoir of the Campos Basin, Southeastern Brazil
Authors: Carrasquilla A.G. , de Abreu C. 
Published: May 2022

Abstract
—The Albian carbonates of the Quissama Formation in the Campos Basin, southeastern Brazil, are important oil reservoirs. They make part of a carbonate platform that formed along the eastern coast of Brazil and the western coast of Africa during the Albian, which resulted in the opening of the South Atlantic Ocean. Subsequently, this reservoir was subjected to different postdepositional diagenetic processes. The present study utilized geophysical well logs to estimate the porosity of this reservoir, based on density, neutron porosity, and sonic logs. The estimates do not show good results when compared with the laboratory measurements. Then, exploring the fact that these logs are obtained with different physical principles, a multiple linear regression and an artificial neural network with Bayesian stochastic approach were applied, which resulted in a better porosity estimate. As porosity is a petrophysical parameter considered significant in the characterization of reservoirs, it was used, hereafter, to estimate permeability and water saturation of the reservoir, applying empirical equations. From there, it was not enough just to estimate the porosity, but was necessary to know what type it is. For this purpose, the concepts of the electrical formation factor, cementation coefficient, tortuosity, and anisotropy were used. With them, the zones with primary intergranular and interparticle porosity as well as secondary porosity, such as fractures, fissures, and vugs, were mapped. It was concluded that, with studies of this type, it is also possible to identify the connected and nonconnected porosities, which permits estimation of the effective porosity along the well.
Guest Editorial: Oilfield Life After the COVID-19 Crash—Part II
Authors: Blue Duncan 
Published: May 2022

In May 2020, I wrote an article for JPT that tried to make sense of what was happening to the oil and gas industry. Remember, this was after the discovery of the pandemic that shut down the world’s economy for many months. Factories and businesses went dark. Roads were empty. People were hunkering down, not knowing or understanding how bad this virus was.
All of this meant that demand for hydrocarbons came to a screeching halt. I had just listened to the earnings calls from Halliburton, Schlumberger, and Baker Hughes, and the outlook was doom and gloom—every executive was trying to reduce spending by millions of dollars.
This came to the detriment of scores of employees and especially those within technology departments—many of which were shuttered.
I said at the time that the industry should be satisfied with whatever technology was available because it would be several years before we would see any new technology. So, how did I do in my prediction?
I will let you judge, but I think we have seen examples of spin being put on what amounts to normal work. Any advancements are mostly cosmetic, with no real, new groundbreaking developments. Now that 2 years have passed and we are cautiously looking around the corner at the world opening up, what do we have to look forward to?
Once again, I listened to the first-quarter earnings calls from the “big three” oilfield services (OFS) companies. The outlook was much more optimistic, and we heard some of the new slants on those calls.
When I wrote the original article in 2020, the letters “ESG” were seldom mentioned in conversation, and especially not on earnings calls. Now, the OFS companies are all about what they are doing to seduce those ESG investors.
Why are they worried? Because all the “traditional” big money that once went into the old-fashioned oil and gas sector is now being swayed by this “new” concept of ESG, which is simply the criteria around environmental, social, and governance practices in any company.
Subsurface Characterization, Monitoring Play Role in Development of Gas-Storage Facilities
Authors: Carpenter Chris 
Published: May 2022

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 204787, “The Importance of Subsurface Characterization and Monitoring During Development and Operation of Underground Gas-Storage Facilities,” by Romain Guises, Emmanuel Auger, and Sanjeev Bordoloi, SPE, Baker Hughes, et al. The paper has not been peer reviewed.
The complete paper describes an integrated subsurface characterization and monitoring approach not only for the construction of underground gas storage (UGS) but also for safe and efficient operation over many decades. Close integration of subsurface understanding with optimization of surface facilities is a critical factor in ensuring optimal UGS performance and deliverability. Another important task of the final phase of UGS facilities design involves enablement of sustainable operation through an asset-integrity-management plan.

Importance of Integrated Subsurface Characterization and Monitoring
The work flows developed to aid integrated subsurface characterization and monitoring play a critical role. These work flows can be grouped as follows:
- Capacity (the potential of the storage site to ensure optimal working capacity)
- Deliverability (the ability of the wells and associated infrastructure to ensure the delivery of the gas from the surface into the reservoir and vice versa)
- Integrity (including reservoir and well integrity with overall asset safety and surface infrastructures)
The element that connects these work flows and ensures collaboration between different work groups and technical disciplines is the 4D dynamic geomechanical model.
Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2
Authors: Li Changzhi , Zhou Hongjuan , Guo Lingling , Xie Dehuan , He Huiping , Zhang Hong , Liu Yixiu , Peng Lixia , Zheng Lisheng , Lu Wenhua , Mei Yan , Liu Zhijie , Huang Jie , Wang Mingdian , Shu Ditian , Ding Liuyan , Lang Yanhong , Luo Feifei , Wang Jing , Huang Bijun , Huang Peng , Gao Song , Chen Jindong , Qian Chao-Nan 
Published: May 2022

Abstract
Background
The outbreak of SARS-CoV-2 continues to pose a serious threat to human health and social. The ongoing pandemic of COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a serious threat to public health and economic stability worldwide. Given the urgency of the situation, researchers are attempting to repurpose existing drugs for treating COVID-19.
Methods
We first established an anti-coronavirus drug screening platform based on the Homogeneous Time Resolved Fluorescence (HTRF) technology and the interaction between the coronavirus S protein and its host receptor ACE2. Two compound libraries of 2,864 molecules were screened with this platform. Selected candidate compounds were validated by SARS-CoV-2_S pseudotyped lentivirus and ACE2-overexpressing cell system. Molecular docking was used to analyze the interaction between S-protein and compounds.
Results
We identified three potential anti-coronavirus compounds: tannic acid (TA), TS-1276 (anthraquinone), and TS-984 (9-Methoxycanthin-6-one). Our in vitro validation experiments indicated that TS-984 strongly inhibits the interaction of the coronavirus S-protein and the human cell ACE2 receptor. Additionally, tannic acid showed moderate inhibitory effect on the interaction of S-protein and ACE2.
Conclusion
This platform is a rapid, sensitive, specific, and high throughput system, and available for screening large compound libraries. TS-984 is a potent blocker of the interaction between the S-protein and ACE2, which might have the potential to be developed into an effective anti-coronavirus drug.
Protect peanut kernels from Aspergillus spp and their mycotoxins during storage by aqueous extract of carob pulp
Authors: El-Desouky Tarek A. 
Published: May 2022

Abstract
Recently, the trend of many studies to replace synthetic antifungals commonly used during storage with natural antifungals; Plants extracts are one of the promising strategies for this purpose. Therefore, this study aimed to evaluate the aqueous extract of carob pulp (AECP) at 1.5, 2.5, and 5mg/ml on the growth of some toxigenic Aspergillus species, and its effectiveness as antimycotoxigenic (aflatoxins and ochratoxin A) during storage red peanut kernels (RPKs) for 90 days. AECP at 5 mg/ml affected inhibition growth, as Aspergillus ochraceus was the most affected, then A. aflatoxiformans recorded (15.7 ± 0.4) and (13.4 ± 0.5), respectively. Whereas study influence of AECP on the accumulation of total AFs and OTA produced by A. parasiticus and A. ochraceus during the storage of RPKs for 90 days. The results reflected that the active compounds in the AECP can protect RPKs for 45 days without detecting any amounts of total AFs and OTA at 5mg/ml. While after 90 days, the percentages of inhibition for the four types (AFB1, AFG1, AFB2, AFG2) and OTA after storage for 90 days compared with positive control samples (85.1, 76.5, 86.5,84.2, and 87.5%), respectively. Finally, AFB1 recorded the lowest inhibition percentages with all treatments; on the contrary, it was OTA.
Pesticide reduction: Technical preference and influencing factors of rice farmers in China
Authors: Liu Di , Huang Yanzhong , Luo Xiaofeng 
Published: May 2022

Abstract
Based on the successful experience of pesticide reduction in China. This study uses survey data from Hubei Province to measure farmers’ preferences for pesticide reduction technologies considering their needs, and compare the heterogeneous factors influencing farmers’ adoption decisions. The results show that larger-scale farmers prefer drone services and efficient machinery, while smaller-scale farmers prefer scientific standards and biopesticides for pesticide reduction. Second, farmers’ adoption behavior of pesticide reduction technologies is mostly influenced by education, risk attitude, income, agricultural labor, scale, rice price, residue testing, brand, training, subsidy, and demonstration. Among them, education, risk attitude, scale, rice price, cost, and training significantly affect farmers’ adoption level of multiple pesticide reduction technologies. Further, higher rice prices and participation in training could promote the use of pesticide reduction technologies on a larger area by farmers. Therefore, the real needs of farmers should be focused on the promotion of pesticide reduction technologies. And pesticide reduction programs in different regions should carry out precise intervention policies. These findings can provide practical policy guidance for effective pesticide reduction in developing countries.
Analysis of Operations Research Methods for Decision Problems Solution in the Industrial Symbiosis: A Literature Review
Authors: Yazıcı Emre , Alakaş Hacı Mehmet , Eren Tamer 
Published: May 2022

Abstract
Industrial symbiosis (IS) is an approach that aims to use resources efficiently by cooperating between independent enterprises in raw materials, energy, and similar sectors. As a result of cooperation, businesses gain economic, environmental, and social benefits. Especially in recent years, IS applications have become widespread due to the problems experienced in the supply of resources. The presence of more than one enterprise in cooperation creates a complex network structure in IS applications. In this complex system, many decision problems are encountered in the establishment and effective maintenance of the industrial symbiosis network. Operations research techniques are at the forefront of the methods used in the solution of decision problems. In this study, studies using operations research techniques in the industrial symbiosis were examined. Studies were divided into four classes according to the methods they used: mathematical modeling, heuristic methods, multi-criteria decision making, and simulation. In the literature review, the studies in the Web of Science (WOS) database are systematically presented by scanning with the determined keywords. As a result of the study, it was analyzed which method was preferred and where the methods could be applied in industrial symbiosis.
Decreasing the melting point? Replacing benzyl chloride with a lignin-degradation product in cellulose etherification.
Authors: Yahia Mohamed , Sundman Ola 
Published: May 2022

Abstract
A cellulose ether that is easier to melt than benzyl cellulose was produced from veratryl alcohol. We successfully synthesised both veratryl chloride and bromide from the alcohol and used these two chemicals to react with Avicel® cellulose to form the novel cellulose ether veratryl cellulose (VC). Spectroscopic characterisation techniques (1H NMR, FTIR) indicate the successful conversion of Avicel® cellulose to the cellulose ether VC, by both routes, at a degree of substitution of 1.4–1.6. Melting measurements of the VC samples show a gradual softening from approximately 110°C and that the VC is melted at below 200°C. XRD analysis confirms that the chemical treatments affect the degree of crystallinity. Size exclusion chromatography (SEC) results show that the products differ significantly in molecular weight. It seems like the VC synthesised with veratryl chloride degrades almost twice as much as if veratryl bromide is used. The cellulose ethers were soluble in DMSO, DMAc and CHCl3.
An Asymmetric Response of Exchange Rate on Export and Import in Four Selected Asian Countries
Authors: Ahmad Riaz , Gul Azeem , Ahmad Sareer 
Published: May 2022

Abstract
The role of exchange rate is active for the economies of backward as well as advanced countries of the world. The motivation of the study is to gauge the asymmetric effect of EXR volatility on the exports and imports of the selected Asian countries namely Pakistan, Malaysia, Korea, and Japan. Quarterly data are taken from period 1980I to 2020IV from IMF and IFS source. Linear and nonlinear ARDL model applied for the estimation. Linear model depicts that there are no significant effects of exchange rate volatility on trade flows, while the results of nonlinear models show relatively more significant outcomes. The result indicates that both linear and nonlinear model indicates that decreased exchange rate volatility will boosts Pakistani exports and imports while increased the exchange rate volatility will hurts both. Nevertheless, the linear model indicates that EXR volatility has no long run effects on Malaysia exports. The findings shows that decreased volatility of exchange rate has stimulates the exports of Malaysia, but increased exchange rate volatility has no effect. Consequently, Malaysia boosts its exports by stabilizing its exchange rate.