bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defectos óseos segmentarios: uso de implantes de titanio trabecular diseñados a medida
Authors: Beatti Matías A. , Zublin Guerra Carlos M. , Guichet Diego M. , Pellecchia Tomás S. 
Published: April 2022

Introducción: Se dispone de una amplia variedad de opciones terapéuticas para la reconstrucción de defectos óseos segmentarios causados por fracturas, tumores o infecciones, pero aún es un desafío en la cirugía ortopédica.
Materiales y Métodos: Se presentan seis casos de pacientes con pérdida ósea masiva tratados mediante lo que denominamos “combinación sinérgica” de una membrana inducida para aportar beneficios biológicos, más un andamiaje (scaffold) de titanio trabecular desarrollado especialmente, según cada paciente, para el aporte de estabilidad y estructura.
Resultados: Cinco hombres y una mujer (edad promedio 30 años) fueron operados con esta técnica. El seguimiento promedio fue de 24 meses. En el posoperatorio inmediato, se logró el restablecimiento del eje, la longitud y la estabilidad mecánica suficiente para iniciar la carga parcial. La carga total, según las condiciones del paciente (dolor, fuerza muscular), demandó un promedio de 25 a 30 días.
Conclusiones: Proponemos una opción de tratamiento poco frecuente en nuestro medio que brinda estabilidad biomecánica suficiente para tolerar la carga precoz recuperando la longitud total del defecto en un solo acto, con excelentes resultados funcionales, entendiendo estas como ventajas frente a las opciones terapéuticas de uso tradicional, como transporte o técnica de Masquelet.
High Levels of PD-L1+ and Hyal2+ Myeloid-derived Suppressor Cells in Renal Cell Carcinoma
Authors: Kusmartsev Sergei , Kwenda Elizabeth , Dominguez-Gutierrez Paul R. , Crispen Paul L. , O’Malley Padraic 
Published: April 2022

Renal cell carcinoma (RCC) patients frequently have increased number of immunosuppressive myeloid cells in circulation. High number of myeloid-derived suppressor cells (MDSCs) in the blood are associated with immune suppression as well as with cancer-related inflammation which drives the mobilization of myeloid cells to tumor tissue. Here, we show that peripheral blood from a previously untreated RCC patient has increased the number of monocytic CD33+CD11b+ MDSCs, which also co-expressed PD-L1 and membrane-bound enzyme hyaluronidase 2 (Hyal2). PD-L1 expression is associated with immune suppression, whereas expression of Hyal2 is associated with inflammation, because Hyal2+ myeloid cells can degrade the extracellular hyaluronan (HA), leading to the accumulation of pro-inflammatory HA fragments with low molecular weight. These findings implicate the potential involvement of monocytic MDSCs in both tumor-associated immune suppression and cancer-related inflammation. Analysis of organotypic tumor-tissue slice cultures prepared from cancer tissue of the same patient revealed the significant presence of PD-L1+ HLA-DR+ macrophage-like or dendritic cell-like antigen-presenting cells in tumor stroma. Interestingly, stroma-associated PD-L1+ cells frequently have intracellular hyaluronan. Collectively, data presented in this study suggest that the interplay between tumor-recruited myeloid cells and stromal HA may contribute to the inflammation and immune tolerance in kidney cancer.
Diplomat in Khaki
Authors: Bacevich A. J. 
Published: April 2022

Hailed by the New York Times as “one of the best soldiers this country has produced,” Frank Ross McCoy was, throughout his distinguished career, much more than just a good soldier. As friend and confidant to such leaders as Theodore Roosevelt, Leonard Wood, and Henry Stimson, he disproves the standard view of the military before 1940 as having no role in American foreign policy. Instead, as A. J. Bacevich ably demonstrates, McCoy was intimately involved in the development of U.S. foreign relations from McKinley’s administration to Truman’s.McCoy began his military career with Leonard Wood in Cuba during the Spanish-American War. After the war, he and Wood (who became military governor) worked together to establish democratic reforms in Cuba. There followed for McCoy a succession of difficult and sometimes dangerous assignments: The Philippines (during the Moro uprising), Mexico, France (as combat commander during World War I), Turkey and Armenia, the Philippines again, Nicaragua (during the Sandinos guerrilla campaign), Bolivia and Paraguay, and China (with the Lytton Commission investigating Japan’s invasion of Manchuria). Following a series of stateside appointments, McCoy served finally as chairman of the Far Eastern Commission, an international body created to determine the fate of postwar Japan.
Becoming Free
Authors: Gill Emily R. 
Published: April 2022

As ethnic, racial, religious, and gender-based groups demand rights to pursue radically diverse lifestyles or maintain their cultural traditions, conflict seems inevitable, even in a free society. Government may offer remedies to social dilemmas—such as affirmative action, curbs on immigration, or protection of gay rights—but these may only fan the flames of resentment. Yet any society that tolerates and protects diversity is more likely to preserve the freedom to live one's life without interference.Emily Gill reexamines the liberal tradition to reconcile its core commitments to autonomy and diversity-values that in theory are complementary but in practice are often at odds-and to show that the interaction of these values determines how we as individuals become free. In Becoming Free, she argues that true freedom is enhanced through the promotion of diversity and the encouragement of rational reflection on the options it allows-and that limited choice or ignorance diminishes such freedom. Yet an incomplete freedom is what many individuals, groups, and states advocate when they commit to particular cultural traditions or religious beliefs, despite the autonomy they themselves enjoy.Gill traces the implications of these conflicting views by drawing on recent scholarship and legal decisions in six areas: national citizenship, cultural membership, ethnicity and gender, religious belief, sexuality, and civic education. By exploring the tensions between autonomy and diversity in such instances as Boy Scouts membership restrictions, gay rights legislation, and education among the Amish, she not only offers an insightful commentary on current issues but also explores the moral foundations of liberal thought.Unlike those who criticize liberalism for its shallow philosophical grounding, Gill shows it to have a substantive moral content grounded in the individual's capacity to make rational decisions based on critical reflection. In her tightly woven arguments, she explores real-world problems in a meaningful way for students and for anyone concerned with the future of liberalism, showing that becoming free is an ongoing process of human and social development.
Democratic Temperament
Authors: Miller Joshua I. 
Published: April 2022

Nineteenth-century psychologist and pragmatist philosopher William James is rarely considered a political theorist. Renowned as the author of The Principles of Psychology and The Varieties of Religious Experience, James is often viewed as a radical individualist with no interest in politics; yet he was a critic of imperialism and absolutism and an advocate of tolerance, and his writing includes a penetrating analysis of political psychology.This first book by a political theorist devoted exclusively to James's theory argues that political concerns were in fact central to his intellectual work. Joshua Miller links James to the contemporary public dialogue by treating him as a theorist of action and exploring the complexities of that theory. He also relates the philosopher's thought to his own political experiences and observations and-by explicating, criticizing, and meditating on James-develops provocative new ideas about issues facing democracy today.At the heart of the book is James's description of the "democratic temperament," which comprises a willingness to act, the placing of public good ahead of private comfort, generosity toward one's opponents, and mutual respect among citizens of different viewpoints, races, genders, classes, and religions. Miller sees this temperament as a healthy corrective to the mean-spiritedness that characterizes so much current political discourse, which is precisely what makes James's insights so relevant to today's political environment. By revealing how James speaks to the paradoxical condition of modern political existence-withdrawal from public life combined with fanatical action-Miller shows how James's views apply to the possibility and problems of reviving participatory democracy in our era.Scholars who have never considered the political aspects of James's work will find in this study a new way of approaching him and of reconsidering radical democracy, while readers unfamiliar with James will find it a highly accessible introduction to a significant aspect of his thought. Democratic Temperament clearly shows that James deserves to be read not only for his recognized genius but also for his fresh and unexpected insights into the possibilities and paradoxes of American democratic political consciousness.
Passions and Interests
Authors: Pomper Gerald M. 
Published: April 2022

Bridging analysis of political parties and political philosophy, Passions and Interests presents eight conceptual models of political parties with particular relevance to American democracy. Gerald Pomper, an internationally recognized scholar, asks three questions: What meanings are attributed to parties? Empirically, to what extent do American parties fit these concepts? How well do these different models serve democratic interests?The analysis encompasses a broad range of individuals, including party theorists from Michels to Downs, practitioners such as Martin Van Buren and Woodrow Wilson, and political philosophers from Burke to Lenin. Beginning with Madison's definition, Pomper views parties as varying combinations of passions and interests. He examines, both empirically and normatively, models of party as bureaucratic organization, governing caucus, cause advocate, ideological community, social movement, urban machine, rational office-seeking team, and personal faction.In further explorations, he analyzes these party models in the light of the historical record and empirical data on American voting behavior, then compares them to proposals for party reform in the United States. In conclusion, Pomper evaluates the contributions of U.S. political parties to democratic values and presents a program to strengthen the parties as institutions of American democracy."The growth of political parties and the extension of democracy proceed along parallel tracks," Pomper contends. "Competitive political parties facilitate, although they do not guarantee, a considerable measure of popular involvement, control, and policy determination. Without them, government is more likely to evidence authoritarianism, violence, and repression."
Presidential Lightning Rods
Authors: Ellis Richard J. 
Published: April 2022

H. R. Haldeman, President Nixon's former chief of staff, is said to have boasted: "Every president needs a son of a bitch, and I'm Nixon's. I'm his buffer and I'm his bastard. I get done what he wants done and I take the heat instead of him." Richard Ellis explores the widely discussed but poorly understood phenomenon of presidential "lightning rods"-cabinet officials who "take the heat" instead of their bosses. Whether by intent or circumstance, these officials divert criticism and blame away from their presidents. The phenomenon is so common that it's assumed to be an essential item in every president's managerial toolbox. But, Ellis argues, such assumptions can oversimplify our understanding of this tool.Ellis advises against indiscriminate use of the lightning rod metaphor. Such labeling can hide as much as it reveals about presidential administration and policymaking at the cabinet level. The metaphor often misleads by suggesting strategic intent on the president's part while obscuring the calculations and objectives of presidential adversaries and the lightning rods themselves.Ellis also illuminates the opportunities and difficulties that various presidential posts-especially secretaries of state, chiefs of staff, and vice presidents-have offered for deflecting blame from our presidents. His study offers numerous detailed and instructive examples from the administrations of Truman (Dean Acheson); Eisenhower (Richard Nixon, John Foster Dulles, Herbert Brownell, and Ezra Taft Benson); LBJ (Hubert Humphrey); Ford (Henry Kissinger); and Reagan (James Watt).These examples, Ellis suggests, should guide our understanding of the relationship between lightning rods and presidential leadership, policymaking, and ratings. Blame avoidance, he warns, does have its limitations and may even backfire at times. Nevertheless, President Clinton and his successors may need to rely on such tools. The presidency, Ellis points out, finds itself the object of increasingly intense partisan debate and microscopic scrutiny by a wary press. Lightning rods can deflect such heat and help the president test policies, gauge public opinion, and protect his political power and public image. Ellis's book is an essential primer for helping us understand this process.
The Enduring Indians of Kansas
Authors: Herring Joseph B. 
Published: April 2022

The Cherokees’ “Trail of Tears” and the forced migration of other Southern tribes during the 1830s and 1840s were the most notorious consequences of Andrew Jackson’s Indian removal policy. Less well known is the fact that many tribes of the Old Northwest territory were also forced to surrender their lands and move west of the Mississippi River.By 1850, upwards of 10,000 displaced Indians had been settled “permanently” along the wooded streams and rivers of eastern Kansas. Twenty years later only a few hundred—mostly Kickapoos, Potawatomis, Chippewas, Munsees, Iowas, Foxes, and Sacs—remained.Joseph Herring’s The Enduring Indians of Kansas recounts the struggle of these determined survivors. For them, the “end of Indian Kansas” was unacceptable, and they stayed on the lands that they had been promised were theirs forever.Offering a good counterpoint to Craig Miner’s and William Unrau’s The End of Indian Kansas, Herring shows the reader a shifting set of native perspectives and strategies. He argues that it was by acculturation on their own terms—by walking the fine line between their traditional ways and those of the whites—that these Indians managed to survive, to retain their land, and to resist the hostile intrusions of the white world. The story of their epic struggle to survive will place a new set of names in the pantheon of American Indian heroes.
The Learning of Liberty
Authors: Pangle Lorraine Smith , Pangle Thomas L. 
Published: April 2022

American schools are in a state of crisis.At the root of our current perplexity, beneath the difficulties with funding, social problems, and low test scores, festers a serious uncertainty as to what the focus and goals of education should be. We are increasingly haunted by the suspicion that our educational theories and institutions have lost sight of the need to perpetuate a core of moral and civic knowledge that is essential for any citizen's education, and indeed for any individual's happiness. Mining the Founders' rich reflections on education, the Pangles suggest, can help us recover a clearer sense of perspective and purpose.With a commanding knowledge of the history of political philosophy, the authors illustrate how the Founders both drew upon and transformed the ideas of earlier philosophers of education such as Plato, Xenophon, Milton, Bacon, and Locke. They trace the emergence of a new American ideal of public education that puts civic instruction at its core to sustain a high quality of leadership and public discourse while producing resourceful, self-reliant members of a uniquely fluid society.The Pangles also explore the wisdom and the weaknesses inherent in Jefferson's attempt to create a comprehensive system of schooling that would educate parents and children and offer unprecedented freedom of choice to university students. An original closing section examines the Founders' ideas for bringing all aspects of society to bear on education. It also shows how Washington, Jefferson, and Franklin presented their own lives as models for the education of others and analyzes the subtle, provocative moral philosophy implicit in the self-depiction of each.The Learning of Liberty is historical and scholarly yet relentlessly practical, seeking from the Founders useful insights into the human soul and the character of good education. Even if the Founders do not provide us with ready-made solutions to many of our problems, the Pangles suggest, a study of their writings can give us a more realistic perspective, by teaching that our bewilderment is in some measure an outgrowth of unresolved tensions embedded in the Founders' own conceptions of republicanism, religion, education, and human nature.
Shaping Modern Liberalism
Authors: Stettner Edward A. 
Published: April 2022

American ideals—liberty, equality, democracy, national unity—are bandied about by liberal politicians as a package deal, inseparably intertwined. But the words often flow together better as rhetoric than they mold together in theory. But, as Herbert Croly and his turn-of-the-century contemporaries found, jelling these appealing yet often conflicting concepts into a liberal philosophy was not nearly as easy as embracing them in a campaign speech.In this first full-length study of Herbert Croly's political theory, Edward Stettner analyzes Croly's writings and examines the events, experiences, and people who influenced Croly's thinking. In the process, he reveals Croly's significant influence on modern liberalism as classical liberal theory merged with progressive philosophy.Croly, founder of The New Republic, expounded on issues from the nationalization of railroads to the Espionage Act in his search for a middle way between socialism and capitalism. Stettner illustrates how Croly's political theory influenced the editorial position of one of the leading liberal journals and how his thought in turn was modified in reaction to national and world events, such as presidential elections and World War I.Stettner portrays Croly as a modest and conscientious intellectual who wholeheartedly came to embrace the progressive movement and consequently helped establish the framework for modern liberalism. In doing so, Stettner emphasizes how Croly's philosophy evolved and how Croly was drawn to the conclusion that a strong national government and individual rights could indeed coexist—if not always serenely—in a democratic society.
Social, political, commercial, and corporate determinants of rural health equity in Canada: an integrated framework
Authors: Leimbigler Betsy , Li Eric Ping Hung , Rush Kathy L. , Seaton Cherisse Lynn 
Published: April 2022

AbstractPeople in rural and remote areas often experience greater vulnerability and higher health-related risks as a result of complex issues that include limited access to affordable health services and programs. During disruptive events, rural populations face unique barriers and challenges due to their remoteness and limited access to resources, including digital technologies. While social determinants of health have been highlighted as a tool to understand how health is impacted by various social factors, it is crucial to create a holistic framework to fully understand rural health equity. In this commentary, we propose an integrated framework that connects the social determinants of health (SDOH), the political determinants of health (PDOH), the commercial determinants of health (ComDOH), and the corporate determinants of health (CorpDOH) to address health inequity in rural and remote communities in Canada. The goal of this commentary is to situate these four determinants of health as key to inform policy-makers and practitioners for future development of rural health equity policies and programs in Canada.
A relation between the quality of life of patients with epilepsy and adherence to treatment as well as retention on therapy
Authors: Lusnikova I. V. 
Published: April 2022

Objective: to demonstrate the mutual influence of the quality of patients’s life during epilepsy, adherence to received anticonvulsant therapy and retention on therapy.Material and methods. We conducted an analytical review of studies published by foreign authors in recent years (published within 2016–2021 were considered of top priority), devoted to the influence of various factors on adherence to therapy in patients with epilepsy. A search for relevant publications was conducted in English-language databases (PubMed/MEDLINE, ClinicalKey) by using key words and phrases: “epilepsy AND quality of life AND adherence to therapy”, “epilepsy AND quality of life AND retention on therapy”, “epilepsy AND adherence to therapy”, “compliance AND epilepsy AND quality of life”, “adherence to therapy AND retention on therapy AND epilepsy”, “nonadherence to therapy AND epilepsy AND quality of life”. After the selection procedure, 22 scientific publications were included in the review.Results. Factors that have a negative impact on adherence to therapy have been identified (comorbid cognitive impairment, the combination of lack of control over seizures and the presence of adverse events after drug administration, depression and anxiety, the need to change the lifestyle for taking the drug, concern about the potential negative consequences of taking the drug, recent uncontrolled seizures, lack of professional implementation, high frequency of taking the drug, problems with doctor-patient relationship, insufficient social support), and factors that have a positive impact (emotional support from the doctor, establishing doctor-patient partnership).Conclusion. There is a relationship between the patient's quality of life and adherence to therapy. Patient adherence to therapy is important for the effectiveness of epilepsy treatment and, along with the severity of epilepsy, is a significant factor affecting the quality of patients’ life during epilepsy. An opportunity for long-term retention on anticonvulsant therapy also has a cross-correlation with quality of life.
Quantitative assessment of regional pulmonary perfusion using three-dimensional ultrafast dynamic contrast-enhanced magnetic resonance imaging: pilot study results in 10 patients
Authors: Zakharova Anna V. , Prits Victoria V. , Pozdnyakov Alexander V. 
Published: April 2022

Background. Currently there is a high demand in reliable noninvasive diagnostic technique assessing the physiological parameters of the lungs. We are exploring the three-dimensional ultrafast MRI sequence as a novel diagnostic modality allowing the assessment of regional quantitative perfusion parameters in pulmonary tissue.
Aim. To assess regional differences in quantitative pulmonary perfusion parameters in 10 volunteers with no evidence of interstitial lung disease by computed tomography, clinical, and laboratory data.
Materials and methods. 10 volunteers with no signs of interstitial lung disease were examined by three-dimensional ultrafast dynamic contrast-enhanced MR imaging using 3D T1-weighted images. The values of pulmonary blood flow (PBF), mean transit time (MTT), and pulmonary blood volume (PBV) for the targeted regions of interest were calculated based on the dynamic image series. For calculations, arterial input function (AIF) was used, as well as the time-intensity curves.
Results. The values of PBF, MTT, and PBV showed statistically significant differences between central and peripheral sections of lungs. Provided model can be implemented for quantitative assessment of regional pulmonary perfusion allows it to be used to determine the reliability of PBF, MTT and PBV values.
Conclusions. Three-dimensional ultrafast MRI sequence is a novel diagnostic modality allowing the assessment of regional quantitative pulmonary perfusion parameters in pulmonary tissue, regardless of physiological features of blood supply mechanisms in different lung regions.