bluuebunny/crossref_metadata_2025_split huggingface dataset:
An in-sight analysis of molecular evolution of Trichoderma as emerging human pathogen
Authors: Ghosh Swapan Kumar 
Published: March 2022

Abstract
Due to climatic changes, anthropogenic activity and pollution, new variants of known species of human pathogens are emerging. Similarly, non-pathogenic Trichoderma spp are becoming pathogenic via molecular evolution. The literature survey provides us that some spp of Trichoderma (T. longibrachiatum, T. viride, T. koningii, T, harzianum, T. citrinoviride, T. reesii, T. atroviride and T. pseudokoningi) infected some organs of patients which were immune-compromised. These are the case of “cross-kingdom host jumps”. The first case report was found in 1970. Latest case report was presented in 2019. So, after 50 years, 42 cases or episodes of Trichoderma infection to human have been recorded. In maximum cases T. longibrachiatum was involved. Proposed pathogenecity factors, molecular evolution and a hypothetical linage of evolution of clinical Trichoderma have been presented here. Although, this opportunistic pathogen is still not reported in COVID-19 patients, it may infect them as COVID-19 patients are with high risk factors. , .
Vitamin B12 and D deficiency as cofactors of COVID-19 vaccine-induced chronic neurological adverse reactions: Two cases and a hypothesis
Authors: Carroll Harriet Amy , Millar Ewen , Deans Kevin Alexander 
Published: March 2022

Abstract
Background: The COVID-19 vaccines have been an essential measure to help reduce COVID-19-related injury and death. However, in some cases, vaccination has caused severe and chronic reactions, akin to post-acute sequelae of COVID-19 (long COVID). Cases: Here we present two cases (Case 1: male, age 43 years, Pfizer BNT162b2 vaccination; Case 2: female, age 30 years, Oxford-AstraZeneca ChAdOx1nCoV-19 vaccination) with severe neurological adverse reaction post-vaccine and concomitant vitamin B12 deficiency. Both cases presented with non-textbook symptomatology of vitamin B12 deficiency. Case 1 had full symptom resolution with vitamin B12 replacement therapy. In Case 2, frank vitamin D deficiency and chronically elevated D-dimer were also found. Case 2 is still undergoing replacement therapy and this manuscript will be updated as appropriate. Discussion: Vaccines, including the COVID-19 vaccines, are known to cause severe and/or chronic neurological reactions in rare cases. We support screening for vitamin B12 deficiency prior to vaccination in high-risk groups (e.g. those following an animal produce free diet), those suffering atypical/chronic vaccine reactions, and those with similar conditions, such as post-acute sequelae of COVID-19 (long COVID). A hypothesis is also presented demonstrating the links between vitamin B12 and vitamin D deficiency and other pathologies (e.g. mast cell activation disorders) that, if validated, could help explain some vaccine hyperreactions.
Biofilm-Based Nutraceuticals: A Better Solution to Diet-Based Interventions for Achieving Healthy Gut Microbiota
Authors: Premarathna M. , Seneviratne G. , Madawala H.M.S.P. 
Published: March 2022

Abstract
Microbial biofilms developed in-vitro and applied to agroecosystems are reported to restore their soil-plant-microbial relationships by supplying a mixture of diverse biochemicals that reinstate network interactions. Here we hypothesize that the same method can also be used to reinstate unhealthy human body ecosystem caused by altered gut microbiota due to modern lifestyle and dietary patterns. In the present study, we tested biochemicals exuded by a developed fungal-bacterial biofilm (BFEx) on the growth and development of five test gut microbes in a simulated gut environment with eight different dietary patterns. Live microbial cell concentrations of the cultures were analyzed after 24 and 48 hours of inoculation using a bacterial viability kit. In addition, BFEx was tested for cytotoxic activity using brine shrimp lethality assay. Results revealed that the live microbial cell concentrations of the mixed cultures increased while they decreased in the monocultures with the application of BFEx in all dietary patterns. The BFEx promoted the growth and possibly dormancy-breaking of the tested gut microbes. However, it seems that there is a need of an interaction of diverse microbes, if a beneficial outcome from the BFEx is to be achieved. Further, the BFEx showed no toxicity to brine shrimp nauplii, instead it supported for their survival for a while by supplying food sources. In conclusion, this biofilm-based method is a better solution than diet-based interventions for achieving healthy gut microbiota because the former is user-friendly and preserves food-choice-freedom of people, unlike the latter.
Exploring the Knowledge and Attitudes of Mothers on Utilisation of Maternity Services in Peri urban District of Central Uganda
Authors: Nalutaaya Janet , Walekhwa Abel Wilson 
Published: March 2022

Abstract
Maternal health services entail the various activities delivered by health workers for pregnant mothers during pregnancy, delivery and after delivery. In Mende sub-county, out of about 1904 pregnant women, only 316 (17%) institutional deliveries were done with 592 having had at least one Antenatal care visit and only 225 reaching the fourth Antenatal care visit in Financial Year 2019/20. We therefore sought to explore the knowledge, attitudes of women and how they influenced maternal health services utilization in a rural subcounty of Wakiso district in Uganda. Methods We conducted a cross sectional study using quantitative methods. The study was conducted at Show Mercy International Health Centre in Mende sub-county - Wakiso District from March to April 2016. We Purposively selected the study participants who were women aged 18–49 years that had ever given birth. A total of 70 participants were enrolled into the study. We open ended questionnaires to collect data from the study participants, quantitative data was collected, coded and analyzed using Microsoft excel windows 16 and SPSS version 16.0. Results Of the 70 mothers, majority were aged 28–37 years (57.1%) with a mean age of 33.5 years, Majority (44.3%) had attained both Secondary followed by primary level education (34.3%). Majority of the women (45.7%) had some form of employment although a good number of them (28.6%) were peasants and casual labourers. We found out that 92.9% were knowledgeable about maternal health services. Furthermore, 46.9% of mothers preferred both Antenatal care and delivery services at the health facility. Conclusion Majority of the mothers were knowledgeable about health facility maternal health services and reported their willingness to use them. The motivating factors for health facility deliveries were (1) healthy baby and pregnancy, (2) getting Mama Kits and mosquito nets, (3) accessing Prevention of Mother to Child treatment services and routine supplements. We therefore recommend further sensitization for HIV/AIDS testing during pregnancy but also maintain the supply of Mama Kits and mosquito nets for improved health facility deliveries.
An Investigation on the Adoption of Rainwater Harvesting Based on the Theory of Planned Behaviour and Norm Activation Model
Authors: Shanmugavel Nagarajan , Rajendran Rema 
Published: March 2022

Abstract
The notion of the study is to reflect the concepts and benefits of rainwater harvesting to the households to recharge ground water that manifests sustainable ground water. Hence to study the adoption of rainwater harvesting the Theory of Planned Behaviour and Norm Activation Model has been synergized. The constructs such as personal norm, subjective norm, intention to acquire rainwater harvesting knowledge, environmental responsibility and environmental concern have been used to explain the adoption of rainwater harvesting. A sample size consisting of 400 participants constructing and likely to construct houses have been had taken for the study. Structural Equation Modelling was used to analyze the data, inter alia moderation and mediation analysis was also done. The study results typically show that all the factors show significant relationship with adoption of rainwater harvesting, similarly intention to acquire rainwater harvesting knowledge moderates the relationship exists between environmental concern; environmental responsibility and rainwater harvesting. Based on the results, significant theoretical and social implications have been made.
TreeSp2Vec: a method for developing tree species embeddings using deep neural network
Authors: González-Rodríguez Miguel A. , Diéguez-Aranda Ulises 
Published: March 2022

Abstract
In recent years, Representation Learning (RL), a subdiscipline of artificial intelligence, has proved a useful resource in many research fields for effectively mapping abstract categories into numeric scales. In this study, we explored an novel application of RL to forestecology, labeled TreeSp2Vec, for developing tree species numeric representations using deep neural networks and data from a National Forest Inventory. Our approach consisted of a supervised species classification of individual trees using as input a set phytocentric and geocentric variables derived from forest inventory data and environmental cartography. Among the tested neural network architectures, a multi-layer perceptron with two hidden layers of 1024 units and an embedding layer of 16 units provided the best apparent and test performances (Matthew’s Correlation Coefficient = 0.89). The developed latent representations (W), or embeddings, were evaluated intrinsically by estimating their correlations with supplementary species descriptors that were not included in the training dataset. The evaluation analysis revealed some significant associations that proved the generality of the embeddingmodel. Some latent dimensions (e.g., W6 and W16) were useful for differentiating species general features, such as conifers vs broad-leaved species, while other dimensions (e.g., W2 and W5) were related to forest ecosystem characteristics such as competition intensity (relative spacing index) and biodiversity (Simpson index). We concluded that the developed embeddings provided accurate and generalizable numeric representations of the considered tree species, which can be used as a ground for further cutting-edge forest modelling approaches and open a new range of artificial intelligence applications in ecology.
A prognostic nomogram based on risk assessment for invasive micropapillary carcinoma of the breast after surgery
Authors: Chen Yuyuan , Yu Caixian , Tang Yiyin , Chen Dedian , Zhu Keying , Guo Rong , Li Zheng , Huang Sheng 
Published: March 2022

Abstract
Invasive micropapillary carcinoma (IMPC) is one of the rare subtypes of breast cancer. A total of 1855 IMPC patients diagnosed after surgery between 2004 and 2014 were identified from the Surveillance, Epidemiology and End Results (SEER) database to build a nomogram. Cox regression analysis indicated that age ≥ 62 at diagnosis, negative ER status, and tumor stage were considered adverse independent factors for overall survival (OS), while patients who were married, white or of other races, received chemotherapy or radiotherapy, had a better postoperative prognosis. The nomogram accurately predicted OS with high internal and external validation consistency index (C index) (0.756 and 0.742, respectively). The areas under the receiver operating characteristic (ROC) curves (AUCs) of the training group were 0.787, 0.774 and 0.764 for 3 years, 5 years and 10 years, respectively, while those of the validation group were 0.756, 0.766 and 0.762, respectively. The results of both decision curve analyses (DCA) and calibration curves demonstrated the good performance of the model. This study constructed a novel nomogram for IMPC of the breast patients after surgery, which has good accuracy and consistency in predicting prognosis and has clinical application value.
Clinical Effects Of Early Rehabilitation Training At Different Time In Patients With Dysphagia After Stroke: Study Protocol For A Multicenter Randomized Controlled Trial
Authors: Yan Hui , Du Ye-Hui , Wang Xing-Lei , Xie Qi , Zhong Juan-Ping , Wu Yin-Ping , Wang Hai-Xia , Dou Xin-Man 
Published: March 2022

Abstract
Background: Stroke is characterized by high morbidity, high mortality, high disability rate, high recurrence rate and heavy economic burden. Post-stroke dysphagia (PSD) is one of the common complications of stroke, which can easily lead to adverse consequences such as repeated aspiration, malnutrition, pulmonary infection, and even asphyxia, and seriously affect the quality of life and prognosis of patients. For PSD patients, scientific and practical early rehabilitation measures can better improve the swallowing function, but the best time for early rehabilitation of PSD patients has not been reported. Therefore, we report on a randomized controlled trial (RCT) in which patients were offered early rehabilitation training using rehabilitation exercises for dysphagia after stroke. This protocol was written according to the SPIRIT 2013 Statement.Methods: This is a multi-center and pragmatic RCT. On the basis of sample size calculation, 180 patients with acute ischemic stroke were randomly enrolled from 3 different hospitals and divided into 4 groups: 1 control group and 3 experimental groups. The control group only received clinical routine electrical stimulation treatment, and the experimental group added rehabilitation exercise on this basis. According to the different starting time of rehabilitation exercise training after the onset of stroke, they were divided into 0-3 days group, 4-7 days group and 8-14 days group. Rehabilitation exercise training lasts for 4 weeks, once in the morning and once in the afternoon, about 30 minutes each time. Primary outcomes were the degree of improvement in patient swallowing function and efficacy assessment. Secondary outcomes, including incidence of choking, pulmonary infection, quality of life, and training compliance rates, were assessed at baseline and 4 weeks after intervention initiation.Discussion: The purpose of this study was to investigate the improvement of swallowing function in PSD patients after early rehabilitation training at different time.Trial registration: chictr.org.c, ID: ChiCTR2000029149. Full Registration on 1 May 2021. https://www.chictr.org.cn/ ChiCTR2000029149.
Voice Recognition im Arbeitsverhältnis — eine datenschutzrechtliche Analyse
Authors: Schmidlin Remo R. 
Published: March 2022

Im Arbeitsverhältnis wird Voice Recognition als Arbeitsmittel, Leistungsmessung, Zugangskontrolle oder Gesundheitsindikator verwendet. Der Einsatz von Voice Recognition muss in datenschutzrechtlicher Hinsicht einen genügend hinreichenden Arbeitsplatzbezug aufweisen. Entscheidend ist in vielen Fällen die Verhältnismässigkeit der Bearbeitung und, insb. bei Cloud-Lösungen, die Wahrung der erforderlichen Datensicherheit. Ist eine Einwilligung des Arbeitnehmers vorausgesetzt, sind hohe Hürden an die Freiwilligkeit zu setzen. Zudem muss sie in den meisten Fällen ausdrücklich sein. Durch die Revision des Datenschutzgesetzes werden Regelungskonzepte wie das Profiling, die Datenschutz-Folgenabschätzung, automatisierte Einzelentscheidungen und technische Anforderungen von der europäischen DSGVO übernommen. Allerdings bringt die Schweizer Ausgestaltung keine in der Praxis relevanten Änderungen im Zusammenhang mit Voice Recognition mit sich.
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Dans le cadre des relations de travail, Voice Recognition est utilisée comme un outil de travail, de mesure des performances, de contrôle d'accès ou d’indicateur de santé. Du point de vue de la protection des données, l'utilisation de Voice Recognition doit présenter un lien suffisant avec le poste. Dans de nombreux cas, la proportionnalité du traitement et, en particulier dans le cas des solutions « Cloud », la préservation de la sécurité des données sont des facteurs décisifs. Même si l'accord du travailleur est expressément requis dans la plupart des cas, le caractère volontaire doit être fortement relativisé. La révision de la loi sur la protection des données permet de reprendre du RGPD européen certains concepts de réglementation tels que le profilage, l'évaluation de l'impact sur la protection des données, les décisions individuelles automatisées et les exigences techniques. La conception suisse n'apporte toutefois pas de changements significatifs et concrets concernant Voice Recognition.
Recent Updates on Oral and Dermal Film-based Formulations and their
Applications
Authors: Kathpalia Harsha , Shinde Saily , Ghonge Mihir 
Published: March 2022

Abstract:
On the one hand, oral formulations are susceptible to problems, including instability accompanied
by erratic absorption throughout the gastrointestinal tract, first-pass metabolism, and patientrelated
and pathological difficulties in consumption. On the other hand, the world has been observing a
shift from conventional dermal formulations to the more cosmetically attractive ones. Amid all these,
polymeric films and film-forming systems have emerged as promising candidates for addressing the
above problems. Oral films have been studied for their potential applications in immediate and sustained-
release formulations and have markedly shown increased plasma concentrations of drugs that
otherwise undergo degradation in the gastrointestinal tract and the liver and have an obvious edge in
treating pathologies of the oral cavity. At the same time, a variety of dermal film formulations have
been developed and studied for treating wounds, skin infections and pathologies, corns and calluses,
and managing pain. This review article attempts to cover significant findings in oral and dermal applications
of these formulations under one umbrella and provide readers with a compilation of relevant
research works and marketed formulations.
Mesenchymal Epithelial Transition (MET): A Key Player in Chemotherapy
Resistance and an Emerging Target for Potentiating Cancer Immunotherapy
Authors: To Kenneth K.W. , Cho William C.S. 
Published: March 2022

Abstract:
The MET protein is a cell surface receptor tyrosine kinase predominately expressed in epithelial
cells. Upon binding of its only known ligand, hepatocyte growth factor (HGF), MET homodimerizes,
phosphorylates, and stimulates intracellular signalling to drive cell proliferation. Amplification
or hyperactivation of MET is frequently observed in various cancer types and it is associated
with poor response to conventional and targeted chemotherapy. More recently, emerging evidence
also suggests that MET/HGF signalling may play an immunosuppressive role and it could confer
resistance to cancer immunotherapy. In this review, we summarized the preclinical and clinical
evidence of MET’s role in drug resistance to conventional chemotherapy, targeted therapy, and immunotherapy.
Previous clinical trials investigating MET-targeted therapy in unselected or METoverexpressing
cancers yielded mostly unfavourable results. More recent clinical studies focusing on
MET exon 14 alterations and MET amplification have produced encouraging treatment responses to
MET inhibitor therapy. The translational relevance of MET inhibitor therapy to overcome drug resistance
in cancer patients is discussed.
Research on Optimal Dispatch of Regional Integrated Energy System Under Uncertain Conditions
Authors: Shi Tao , Zhao Zi-gang , Ye Rong-bo 
Published: March 2022

Background:
This paper is focused on the uncertainty influence on dispatch decision-making of regional integrated energy system caused by multiple power prediction errors of intermittent power generation, such as: Wind power generation, photovoltaic power generation, etc.

Objectives:
The objective of dispatching decision-making model is the minimization of energy consumption cost, considering the constraints such as: Balance of supply and demand, power, and capacity limitation of each energy facility, etc.

Methods:
A modeling method based on copula function is proposed to quantify the joint random probability distribution characteristics of multipower errors.

Results:
Then a stochastic optimal dispatching decision-making model of the integrated energy system considering multiple power prediction errors is provided. An algorithm based on the combination of Monte Carlo and genetic algorithm is also provided to solve this model.

Conclution:
Finally, a case study is carried out based on a typical system to verify the effectiveness of the model and algorithm. The results show that the quantitative analysis of the joint random distribution characteristics of multiple power prediction errors and the application of stochastic dispatch model are helpful to improve the confidence level of the scheduling decision-making scheme of the regional integrated energy system, and have certain utility in engineering.
PEMANFAATAN VIDEO TUTORIAL (DEMONSTRASI) PADA PEMBELAJARAN PCKI DI MASA PANDEMI COVID-19
Authors: Nurwati Nani , Purwanti Heni 
Published: March 2022

Penelitian ini bertujuan untuk memaksimalkan pembelajaran siswa kelas XII, mata pelajaran PCKI (Pembuatan Cake dan Kue Indonesia) pada siswa kelas XII Kuliner 3, SMK Negeri 4 Yogyakarta, dengan materi praktik menghias cake pada acara perkawinan di masa pandemi Covid-19 melalui video tutorial demonstrasi. Strategi pengumpulan data yang digunakan adalah deskriptif kualitatif dengan memanfaatkan data kualitatif yang kemudian dijabarkan secara deskriptif. Menghias cake untuk acara perkawinan membutuhkan ketelitian, ketrampilan, dan kreativitas terutama pada saat mengapilkasikan butter cream, membuat bentuk hiasan dengan butter cream, memilih warna butter cream untuk hiasan, dan memilih ornamen untuk meningkatkan penampilan cake. Hasil penelitian menunjukkan bahwa pembelajaran praktik menghias cake untuk acara perkawinan dengan memanfaatkan video tutorial demonstrasi berdampak positif bagi siswa, ditunjukkan dengan pengumpulan tugas siswa yang tepat waktu, antusias serta semangat siswa dalam berdiskusi dan bertanya kepada guru saat mendapatkan kesulitan. Dari hasil foto praktek yang dikirimkan oleh siswa dapat dilihat bahwa dengan memanfaatkan video tutorial demonstrasi siswa dapat menggali potensi dan kreativitas sehingga meningkatkan pengetahuan dan keterampilan dan pada akhirnya berpengaruh pada hasil belajar siswa.
UPAYA MENGEMBANGKAN MINAT MENULIS SISWA MELALUI GAWAI MENUJU NEW NORMAL
Authors: Purnami Purnami 
Published: March 2022

Abstrak Tujuan dari penelitian ini adalah untuk mengetahui seberapa besar pengaruh gawai terhadap minat menulis siswa kelas VI, SDN Karangtengah IV menuju persiapan new normal. Dalam Penelitian ini digunakan pendekatan kualitatif deskriptif. Metode yang digunakan adalah melalui pemanfaatan gawai dalam kegiatan pembelajaran. Hasil penelitian menunjukkan bahwa dalam kegiatan menulis terutama pada saat pembelajaran dari rumah, siswa kelas VI SDN Karangtengah IV masih rendah. Namun, dalam penggunaan gawai dalam berkomunikasi sangat lancar. Hal tersebut yang mendorong untuk meneliti seberapa besar pengaruh gawai dalam menumbuhkan minat menulis siswa menuju persiapan new normal. Tahapan berupa perencanaan, pelaksanaan, dan evaluasi pembelajaran melalui pemanfaatan gawai dalam menumbuhkan minat menulis siswa. Siswa mendapatkan tugas melalui pembelajaran luring dan daring. Tugas tersebut berupa pemanfaatan video dan gambar melalui gawai yang mereka miliki, kemudian dikembangkan menjadi tugas tertulis. Kendala yang terjadi di lapangan adalah ada beberapa siswa yang tidak memiliki gawai sendiri, sehingga pengerjaan tugas menjadi tidak tepat waktu. Disamping itu, terkadang sulit mendapatkan sinyal. Efektifitas pemanfaatan gawai pada kegiatan pembelajaran adalah adanya peningkatan minat menulis pada siswa. Minat menulis tumbuh karena adanya rasa senang dengan media gawai tersebut. Dari rasa senang itulah timbul minat yang lebih terhadap tugas yang diberikan. Hasil akhir menunjukkan bahwa dengan pemanfaatan gawai dalam kegiatan pembelajaran, minat menulis di kelas VI pada SDN Karangtengah IV mengalami peningkatan.