bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ligation of Left Gastric Vein May Cause Delayed Gastric Emptying After Pancreatoduodenectomy: A Retrospective Study
Authors: Kimura Koichi , Minagawa Ryosuke , Izumi Takuma , Otake Akihiko , Aoyagi Takehiko , Taniguchi Daisuke , Yano Hiroko , Kajiwara Yuichiro , Minami Kazuhito , Nishizaki Takashi 
Published: March 2022

Abstract
Background
This study aimed to determine which running pattern of the left gastric vein (LGV) is most frequently ligated in subtotal stomach-preserving pancreatoduodenectomy (SSPPD) and how LGV ligation affects delayed gastric emptying (DGE) after SSPPD.
Methods
We retrospectively analysed 105 patients who underwent SSPPD between January 2016 and September 2021. We classified the running pattern of LGV as follows: type 1 runs dorsal to the common hepatic artery (CHA) or splenic artery (SpA) to join the portal vein (PV), type 2 runs dorsal to the CHA or SpA and joins the splenic vein, type 3 runs ventral to the CHA or SpA and joins the PV, and type 4 runs ventral to the CHA or SpA and joins the SpV. Univariate and multivariate analyses were used to identify differences between patients with and without DGE after SSPPD.
Results
Type 1 LGV running pattern was observed in 47 cases (44.8%), type 2 in 23 (21.9%), type 3 in 12 (11.4%), and type 4 in 23 (21.9%). The ligation rate was significantly higher in type 3 (75.0%) LGVs (p < 0.0001). Preoperative obstructive jaundice (p = 0.0306), LGV ligation (p < 0.0001), grade B or C pancreatic fistula (p = 0.0116), and sepsis (p = 0.0123) were risk factors for DGE in the univariate analysis. Multivariate analysis showed that LGV ligation was an independent risk factor for DGE (odds ratio: 13.60, 95% confidence interval: 3.80-48.68, p < 0.0001).
Conclusion
Type 3 LGVs are often ligated because they impede lymph node dissection; however, LGV preservation may reduce the occurrence of DGE after SSPPD.
One-dimensional infiltration equation based on Philip, Green, and Ampt models (El Kerma-Oran-Algeria)
Authors: Nabila BOUALLA 
Published: March 2022

Abstract
The control of water discharges in the El Kerma area is of paramount importance. These soils, which are generally rich in clay materials, are characterized by a (very) low permeability that leads to a rapid rise in pore pressure in the event of a massive influx of water. Thus, the prediction of the rate of water infiltration is essential for the prevention of flood risks. It is mainly stormwater that must be feared. However, these waters cannot always be carried out in a network, because of the connection distance, or the insufficiency of its section in front of the extension of the waterproofed soils, which transport too fast high flows. Sanitation and urban development specialists are interested in the increase in impervious surfaces due to the development of urbanization that leads to excessive runoff flows during rainy periods. Their control is therefore much more delicate than that of wastewater, whose flows are generally low and spread over time. The objective of this part is to study the infiltration regimes by using three models chosen for their simplicity (Philip, Green, and Ampt) and compare them to obtain the most effective model. Unfortunately, the result was not adequate since the infiltration time of the treated sample was short.
Association Between Urate-lowering Therapies and Cognitive Decline in Community-dwelling Older Adults: a Post-hoc Analysis of the MAPT Study.
Authors: MOLET-BENHAMOU Luc , GIUDICI Kelly VIRECOULON , BARRETO Philipe , CANTET Christelle , ROLLAND Yves 
Published: March 2022

Abstract
IntroductionLong-term use of urate-lowering therapies (ULT) may reduce inflammaging and thus prevent cognitive decline during aging. This article examined the association between long-term use of ULT and cognitive decline among community-dwelling older adults with spontaneous memory complaints.Material and methodsWe performed a secondary observational analysis using data of 1,673 participants ≥70 years old from the Multidomain Alzheimer Preventive Trial (MAPT Study), a randomized controlled trial assessing the effect of a multidomain intervention, the administration of polyunsaturated fatty acids (PUFA), both, or placebo on cognitive decline. We compared cognitive decline during the 5-year follow-up between three groups according to ULT use: participants treated with ULT during at least 75% of the study period (PT≥75; n=51), less than 75% (PT<75; n=31), and non-treated participants (PNT; n=1,591). Cognitive function (measured by a composite score) was assessed at baseline, 6 months and every year for 5 years. Linear mixed models were performed and adjusted for age, sex, body mass index (BMI), diagnosis of arterial hypertension or diabetes, baseline composite cognitive score, and MAPT intervention groups. ResultsAfter the 5-year follow-up, only non-treated participants presented a significant decline in the cognitive composite score (mean change -0.173, 95%CI -0.212 to -0.135; p<0.0001). However, there were no differences in change of the composite cognitive score between groups (adjusted between-group difference for PNT vs. PT<75: 0.089, 95%CI -0.160 to 0.338, p= 0.484; PNT vs. PT≥75: 0.174, 95%CI -0.042 to 0.391, p= 0.115).ConclusionUse of ULT was not associated with reduced cognitive decline over a 5-year follow-up among community-dwelling older adults at risk of dementia.
Balancing of Cost-Oriented U-Type General Resource-Constrained Assembly Line: New Constraint Programming Models
Authors: Alakaş Hacı Mehmet , Pınarbaşı Mehmet 
Published: March 2022

Abstract
In simple assembly line balancing problems, it is assumed that the resources required to perform the tasks are available at the relevant station for task assignment. However, each task may need different resource types depending on the difficulty, complexity and technical requirements of the tasks in real life. For this reason, tasks and resources belonging to these tasks must be assigned to the relevant station while balancing the line. In this study, the resource-constrained U-shaped assembly line balancing problem(U-GRCALBP) is discussed. According to the literature research, there is no study dealing with U-GRCALBP. Two different constraint programming (CP) models that define the resource constraints as "and/or" constraint types with concurrent resource types have been developed. In these models, the sum of resource usage costs and station opening cost minimization is aimed. The models are explained with an illustrative example and the efficiency of the models was tested by deriving new resource constraints on sample data sets. The number of stations obtained, the total number of resources used, total station opening and resource usage costs, and CPU time were used as performance criteria. According to the numerical results, it has been shown that both models are effective in solving the problem.
Molecular Responses of Arabidopsis MET1 Cytosine Methyltransferase Mutants to Salinity
Authors: Yeşildirek Yağmur Vecide , Arıkan Burcu , Kara Neslihan Turgut 
Published: March 2022

Abstract
In this study, we investigated the morphological and molecular responses of Arabidopsis met1-7 and met1-3 null mutants under salinity stress. In this context, global DNA methylation changes of mutants exposed to salt stress were compared and expressions of DRM2, Pol IV and Pol V genes known to be involved in DNA methylation in plants were analyzed. We found that met1-7 and met1-3 mutants have a higher rate of hypomethylation than Col-0 under all conditions. According to the results of gene expression analysis, the increase in expression of DRM2, Pol IV and Pol V genes involved in CNN methylation in mutants than Col-0 plant suggests that hypomethylation is directly related to CG regions, but in met1 mutants, the lack of CG methylation is tried to be compensated by RdDM. In addition, we analyzed the expression of the TERT gene as a stress response indicator in order to examine the effect of salt stress on the telomerase enzyme in met1-7 and met1-3 mutants. Contrary to expected, we found that there was an increase in the expression of TERT gene in the salt stress applied plants. Within the scope of all the data, it is thought that in met1 mutants RdDM pathway is activated in order to deal with the lack of DNA methylation in CG islands. As a conclusion, it is believed that the morphological and molecular data obtained on the effects of NaCl application to met1 mutants will help us to understand the epigenetic basis of stress mechanisms.
TINGKAT KEPUASAN MASYARAKAT PADA PELAYANAN PAJAK KENDARAAN BERMOTOR DI KANTOR SAMSAT TANJUNGPINANG
Authors: Satriadi S 
Published: March 2022

The quality of public services is determined by the service providers (apparatus),who must realize that he is a servant of the people and they must be served well,such that the factors and the indicators in determining the quality of publicservices can be met. This would ultimately have an impact on increasing thequality of public services. Society satisfaction in the opinion from public inobtaining services of the public service providers aparatus by comparing theexpectation and needs. This research entitled is the level of public satisfactionin the service taxes on motor vehicles at Samsat Office Tanjung pinang. The method used in this research is quantitative methods with questionnaire to 34 responden as samples. This questionnaire as an data collecting instruments.These results indicate service quality to public satisfaction in the service taxeson motor vehicles at Samsat Office Tanjung pinang is enough satisfactionslevels, with the frequencis results is 18 and percentage 52,9 %.Kualitas pelayanan publik ditentukan oleh penyedia layanan (aparatur), yangharus disadari adalah mereka sebagai penyedian layanan kepada masyarakatdan mereka harus dilayani dengan baik, sehingga faktor-faktor dan indikator dalam menentukan kualitas pelayanan publik dapat dipenuhi. Hal ini padaakhirnya akan berdampak pada peningkatan kualitas pelayanan publik.Opini masyarakat terbentuk dalam membangun kepuasan masyarakatdari para penyedia layanan publik dengan membandingkan harapan dankebutuhan. Penelitian ini berjudul tingkat kepuasan publik dalam layananpajak kendaraan bermotor di Kantor Samsat Tanjungpinang. Metodeyang digunakan dalam penelitian ini adalah metode kuantitatif denganmemberikan kuesioner kepada 34 responden sebagai sampel. Kuesioner inisebagai instrumen pengumpulan data. Hasil menunjukkan bahwa kualitaspelayanan untuk kepuasan publik di layanan pajak kendaraan bermotordi Kantor Samsat Tanjungpinang dengan tingkat yang cukup puas, denganfrequensi hasil yaitu 18 dan persentase 52,9%.
Estudio de la vida real sobre el modelado numérico de las arcadas temporales superiores e inferiores en imágenes de fondo de retina
Authors: Rodríguez-Villalobos Ángel Jonathan , Alvarado-Carrillo Dora Elisa , Cruz-Aceves Iván , Castellón-Lomelí Chrystian Irán , López-Montero Luis Miguel , Hernández-González Martha Alicia , Giacinti David Jaime 
Published: March 2022

Introducción: La alta prevalencia de Diabetes Mellitus tipo 2 en México ha posicionado a la retinopatía diabética como la principal causa de ceguera en adultos en edad productiva en México. Por ello, la detección oportuna de este padecimiento es una tarea prioritaria para el sistema público de salud. En el presente artículo se estudia el desempeño de un nuevo algoritmo para la determinación de la forma de la arcada temporal mayor de la retina, mediante el uso de técnicas de segmentación de imágenes y modelado numérico de curvas.
Método: La metodología propuesta emplea Filtros Gaussianos de Correspondencia que realzan la geometría de los vasos sanguíneos. Posteriormente, la estructura vascular es segmentada mediante la umbralización global de la imagen realzada. Dicha segmentación es utilizada como entrada para construir un modelo numérico de las arcadas temporales superior en inferior, utilizando funciones Spline.
Resultados: La evaluación de desempeño se realizó utilizando 136 imágenes de pixeles. El algoritmo de segmentación automática de venas de la retina mediante el método GMF obtuvo un valor de Accuracy de 0.9852; el algoritmo de modelado numérico dio un resultado de 6.01 pixeles en la métrica de la distancia media al punto más cercano (MDCP). Otro estudio previo reportó 12.33 pixeles. Con respecto al tiempo, se reportó un tiempo promedio de 10.65 segundos por imagen.
Discusión: El método propuesto fue capaz de realizar eficientemente el modelado numérico de las arcadas temporales en imágenes de fondo de ojo. Los resultados demuestran que este método es una herramienta computacional útil para el diagnóstico de alteraciones en la anatomía del ojo.
Amazon Rainforest: A Natural Source for New Therapeutic Alternatives
against Neglected Tropical Diseases
Authors: da Silva Santos Soraya , Silva João Vitor , Boniface Pone Kamdem , Giarolla Jeanine 
Published: March 2022

Abstract:
The Amazon rainforest has wide and unique biodiversity, which is an important source of
natural productsfor the development of drugs. Neglected tropical diseases (NTDs) represent a major
health problem as they affect over 1 billion people, especially vulnerable populations living in tropical
and subtropical regions. Currently available drugs are generally inadequate for the majority of these
diseases, thus, there is an urgent need for new treatments. The present review aims to summarize upto-
date and comprehensive information on the efficacy of the Amazon plants, in treating certainneglected
tropical diseases. According to the literature information, several compounds (phenolics, alkaloids,
terpenoids and steroids, among others) which were isolated from plants of the Amazon forest
showed in vtro activity against Leishmania sp., Trypanosoma cruzi, the parasites responsible for
leishmaniasis and Chagas disease, respectively. Moreover, extracts and essential oil from certain
plants were reported to have mosquito repellent and insecticidal activities against Aedes aegypti, the
vector of dengue, and chikungunya. This review demonstrated that the Amazonian rainforest is endowed
with pharmacologically active plants which can be used as a starting point for the development
of new drugs against NTDs, such as leishmaniasis, Chagas disease, dengue, and chikungunya.
Cytokine Response of CD4+ T-Lymphocytes with Red Rose (Rosa Rosaceae – Pierre de Ronsard) Extracts by in Vitro Evaluation
Authors: Arokiaraj Mark Christopher , Menesson Eric 
Published: March 2022

Background. Red rose extract is known to have anti-inflammatory and immune-modulation effects. In this study, the red rose extract was tested on CD4+T lymphocytes in vitro, and cytokine response was evaluated.
Materials and Methods. The red rose (Rosa Rosaceae - Pierre de Ronsard) extract used in this study was prepared and stored at -20° C until use. CD4+T-cells were seeded in 96-well plates at 313,500 cells/well in 100μ l cell culture medium in duplicate. One-half of the wells were used for biomarker screening in the culture medium, and the other half was used for cytotoxicity assay. Twenty-four hours after plating, the cells were treated in duplicate with 100μ l of the red rose extract diluted at 0.5%, 0.1%, 0.05%, 0.01% and 0.005% (v/v) in the cell culture medium or with culture medium only as control for 72 hours. Some other wells were allocated for untreated cells, and cells treated with the rose extract at 0.005% for 48-h incubation time.
Results. Several cytokines (GRO; IFN-γ; IL-1α, 6, 10; MCP-1; RANTES; TGF-β1; TIMP 1, 2; Ang1, Ang2; G-CSF; MMP-9; and VEGF R2) were elevated. Except for MMP-9, which had fold changes > 2, other cytokines were minimally elevated at various concentrations and timing of rose extract treatment. None of the mentioned cytokines were less than 0.8-fold after treatment with the rose extract. Cytotoxicity assay revealed insignificant changes in the viability of T-cells.
Conclusions. There was a mild elevation in few inflammatory markers by CD4+ T-lymphocytes after in vitro treatment with the red rose extract (Rosa Rosacea - Pierre De Ronsard). Further in vitro and in vivo studies are required to evaluate the benefits of the red rose extract in immune regulation.
Ideologi Gender Dalam Film Soviet ДВЕНАДЦАТЬ МЕСЯЦЕВ ‘Dua Belas Bulan’
Authors: Thera Widyastuti , Utami Annisa Salshabia Nur 
Published: March 2022

Fairy tales are often identified with messages to be conveyed to readers, and can also contain certain ideologies. Many studies have analyzed the relations between fairy tales and gender ideology. Therefore, the writer chose the Soviet film entitled Двенадцать месяцев 'Twelve Months' (1972) as the source of research data, because there are additional elements written by Marshak. The purpose of this research is to describe the actant scheme and the characterization in the film, and to analyze whether gender ideology is present in the film, and how the ideology is presented. The approach used is the Greimas' actantial model approach. The method used in this research is qualitative and descriptive analytical methods. The result of this research shows that there are still gender stereotypes in the film, which can be seen from the actantial schemes and the characterization of the characters.
Exploring the health impacts and inequalities of the new way of working: findings from a cross-sectional study.
Authors: Griffiths Melda Lois , Gray Benjamin J , Kyle Richard G , Davies Alisha R 
Published: March 2022

BackgroundEmployment is a wider determinant of health, and one of the most striking societal transformations witnessed during the SARS-CoV-2 (COVID-19) pandemic was the sudden shift to working from home (WFH). Within the COVID-19 recovery and efforts to tackle climate change, having large proportions of the workforce WFH has clear benefits. However, the wider adoption of such measures should account for inequalities in accessing home working, the workforce’s preferences for the future, and crucially, the impact that WFH might have on the workforce’s health.
MethodsA nationally-representative household survey was undertaken across Wales (Public Health Wales’ COVID-19, Employment and Health in Wales study), with cross-sectional data on home-working being collected between November 2020 and January 2021 from 615 employed working-aged adults in Wales (63.7% female, 32.7% aged 50-59). Respondents were asked about their ability to WFH, their perceptions of its impact on their health and their preferences for time spent home-working in future.
FindingsOver 50% were able to WFH, and showed a preference towards home-working to some capacity, with over a third wishing to WFH at least half the time. However, those living in the most deprived areas, in atypical employment, with high wage precarity or with limiting pre-existing conditions were less likely to report being able to WFH. Of those that could WFH, over 40% reported that it worsened their mental well-being and loneliness, and for people in poorer health, home-working negatively impacted their diet, physical activity, smoking and alcohol use. People aged 30 to 39 and those who lived alone were more likely to report wanting to spend some time working in an office/base instead of at home.
ConclusionsThe new way of working introduces new challenges to preserving workforce mental well-being, regulating health behaviours and tackling inequalities. Our findings shine a light on the negative health impacts associated with WFH (particularly for those already in poorer health), highlight how disadvantaged population sub-groups face further inequalities through being less able to WFH, and provide novel observations of the preferred working models of different sub-groups within the population. Hybrid approaches, combining home and work-based employment are preferred and could alleviate the negative health impacts associated with WFH. Addressing inequalities across the workforce to ensure that everyone is as able to participate in this transformative shift in ways of working is key.
Covid-19 Digital health literacy of Sofia University IT students – preliminary results
Authors: Patias Ioannis 
Published: March 2022

BackgroundThe SARS-CoV-2019 pandemic and the Coronavirus Disease 2019 (COVID-19) virus, made us use various sources of health information available on different digital platforms on the Internet, thus brought in front side issues related to health literacy (HL). People using digital information platforms not always have the ability to adequate evaluate the acquired health information. Even more IT professionals are often engaged in systems development, where their ability to provide the system with reliable, checked input as for example training data and information is crucial. Namely this makes IT students, as future professionals, health literacy important case for study.
MethodsFor the purpose a Questionnaire developed by Dadaczynski, K., Okan, O. & Rathmann, K. in 2020 as COVID-19 Health Literacy Survey: University Students (COVID-HL Survey), and the respective Scale Documentation under the Public Health Centre Fulda (PHZF) at the Fulda University of Applied Sciences & Interdisciplinary Centre for Health Literacy Research at Bielefeld University, was used. The main goals are to assess digital HL of university students; explore the different digital sources of information students consult when seeking for COVID-19 information; capture student’s future time perspective/worries; and also assess students Sense of Coherence under this health situation.
FindingsMost (roughly above 60%) of respondents indicated that it was easy to search, acquire, evaluate reliability, and determine relevance for health information related to COVID-19, SARS-CoV-2019, and other related topics. Immersive the amount of students (above 85%) that crosscheck acquired health information in both English and Bulgarian languages. As for the various possibilities of how to get information about the coronavirus and related topics on the Internet, the respondents indicate most often they use search engines (e.g. Google, Bing, Yahoo!), followed by official Health portals (for example, the Bulgarian unified information portal, the current news – Ministry of Health, and the Regional Health Inspectorate).
ConclusionsThe preliminary results so far show that most of the students of the current sample reported high HL. May be their ability to crosscheck health information explains their satisfaction regarding to this information. Young people as the students in Sofia University trust modern digital platforms, but also have a high rated opinion for the official heath authorities in the country, including the developed Bulgarian unified information portal, the Ministry of Health, and the Regional Health Inspectorate web pages. The study is still ongoing. More results and discussion should follow the responses acquisition completion.