bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects on Wavefront Aberration after Short-term Wear of Senofilcon A Photochromic Contact Lens
Authors: Recep Ömer Faruk , Kocabas Dilara Ozkoyuncu , Kiziltoprak Hasan , Ozulken Kemal 
Published: November 2022

Abstract
Background To assess the variability in wavefront aberrations with short-term wear of photochromic senofilcon A contact lenses in both its activated and inactive states.
Methods and Material In this cross-sectional study, 20 participants who had previously used soft contact lenses were enrolled. Corneal aberrometry measurements were performed on each subject, without contact lenses, using Sirius Scheimpflug-Placido topography. The photochromic lenses were illuminated using a blue-violet light (λ
max = 420 nm) so as to provoke an activated state, and measurements were taken with the lenses inserted, in both states. The root mean square (RMS) of the aberrations was calculated, and the higher- and lower-order aberrations, astigmatism, coma, spherical aberration, and trefoil measurements were evaluated using a 5.0-mm pupil diameter.
Results The average contact lens sphere power was − 2.33 ± 1.07 D. The mean refractive errors with contact lens wear were 0.07 ± 0.18 D for the sphere and − 0.26 ± 0.15 D for the cylinder. The mean RMS values for all the corneal aberrations showed no statistically significant differences with and without contact lenses (p > 0.05). In a bivariate correlation analysis, there was a positive correlation between contact lens sphere power and coma (vertical and horizontal) in the activated state (r = 0.455, p = 0.44 and r = 0.495, p = 0.27, respectively).
Conclusion The photochromic contact lenses did not influence ocular aberration during short-term wear, even when the photochromatic additive was activated. This property may help to provide more comfortable vision with lens wear. This finding needs to be verified by further studies.
Do Sports-related Concussions Induce Subsequent Injuries in Elite
Male Football Players?
Authors: Beaudouin Florian , Tröss Tobias , Hadji Abed , Steendahl Ida Bo , Meyer Tim , Fünten Karen Aus der 
Published: November 2022

AbstractTo assess the players’ risk of a subsequent injury after sustaining
concussive injuries and their return-to-competition in German professional
men’s football. A prospective injury database in the 1st
Bundesliga was created encompassing 7 seasons
(2014/15–2020/21). Cox proportional hazard model
analyzed whether a concussive injury increased the risk of a subsequent injury
in the first year after the index injury. 6,651 injuries were reported
(n=182 concussive injuries). The incidence rate was 0.15 (95% CI
0.13–0.17) per 1000 football hours. A concussive injury was associated
with only a slightly numerical higher risk of 7% (HR=1.07,
95% CI 0.78–1.47) in the subsequent year after the injury
compared to a randomly selected non-concussive injury, but the effect was not
significant. The risk was higher after 6–12 months post-SRC reaching
70% (HR=1.70, 95% CI 1.15–2.52). For 0–3
months (HR=0.76, 95% CI 0.48–1.20) and 3–6
months (HR=0.97, 95% CI 0.62–1.50) the injury risk was
lower. The present data do not confirm previously published investigations about
an increased injury risk after SRC. Contrasting effects of lower hazard ratios
were found early after SRC, followed by an increase after 6–12 months.
Further research should look into compliance rates with regards to
return-to-competition protocols.
Predictive Factors Associated with Naloxone Prescription among Pregnant People Admitted for the Management of Opioid Use Disorder
Authors: Gonzalez Alba M. , Arlandson Mary E. , Patel Ashlesha , Premkumar Ashish 
Published: November 2022

Objective Our objective was to examine the biomedical and sociodemographic factors associated with the prescription of naloxone among pregnant people with opioid-use disorder (OUD) who were admitted for initiation of medications for OUD (i.e., buprenorphine-containing medications or methadone) following the implementation of a statewide initiative focused on reducing adverse perinatal health outcomes.
Study Design This is a single-site, retrospective cohort study of pregnant people admitted for the management of OUD at an urban, tertiary care center between 2013 and 2020. The primary outcome is evidence of a prescription of naloxone, ascertained from the electronic medical record. Bivariate and multivariable logistic regression modeling was performed to evaluate biomedical and sociodemographic variables associated with a prescription for naloxone. Covariates for inclusion in the multivariate logistic regression model were selected based on a p < 0.05 on bivariate analysis. Statistical significance was set at p < 0.05.
Results One hundred and thirty-nine participants met the inclusion criteria. On bivariate analysis, people who received naloxone were more likely to be admitted after the initiation of a statewide initiative focused on reducing adverse perinatal outcomes associated with perinatal OUD. Those individuals reporting intravenous drug use (IVDU) were less likely to receive naloxone. On multivariate logistic regression, after controlling for IVDU and epoch of admission, both IVDU (adjusted odds ratio [aOR]: 0.27, 95% confidence interval [CI]: 0.11–0.70) and epoch of admission (aOR: 3.48, 95% CI: 1.28–9.50) were independently associated with receipt of prescription of take-home naloxone.
Conclusion Naloxone prescription was independently associated with the epoch of admission and route of drug administration. These data can be useful in the evaluation and development of clinical practices to increase rates of naloxone prescription in pregnant people with OUD admitted for inpatient management.
Key Points
Epidermal Inclusion Cyst Formation: Late Complication of Carpal Tunnel Release
Authors: Kamenko Srdjan , Richards Holden , Madsen Russell Jared , Chang Shiliang 
Published: November 2022

Abstract
Background Epidermal inclusion cysts (EIC) are epidermally lined, keratin containing cysts which occur when keratinizing epithelium becomes imbedded in deeper subcutaneous tissue, usually following penetrating trauma, or, rarely, surgery. We describe a case of an EIC presenting as a late complication following open carpal tunnel release (CTR).
Case Description A 64-year-old woman with a history of left open CTR 17 years prior presented to our institution with unprovoked left palmar pain, swelling, and fluctuance. Computed tomography imaging confirmed the presence of a multiloculated abscess involving the hypothenar musculature. The abscess developed at the site of a small, pre-existing, asymptomatic mass that the patient recalls developed within months of CTR surgery. She was initially treated with antibiotics and bedside incision and drainage, but required further operative exploration in the setting of persistent erythema and drainage. An inflamed cystic structure consistent with an infected EIC was identified and completely excised. Her wound healed by secondary intention. Her postoperative course was uncomplicated. Pathology confirmed a diagnosis of EIC.
Literature Review Only one other case report was found in which the patient presented within 2 years following CTR surgery with what was later confirmed to be an EIC and recurrent median nerve compression symptoms.
Clinical Relevance To prevent a delay in definitive surgical care, EIC rupture and subsequent infection should be considered in the differential diagnosis when evaluating patients with a history of prior hand surgery who are presenting with an unprovoked hand abscess, as incision and drainage alone will not adequately treat an EIC.
Abdominoperineal Approach to Uterovaginal Anastomosis in Cervical Dysgenesis: A Case Report and Review of Literature
Authors: Halder Ajay , Patel Shweta , Dubey Pankhuri 
Published: November 2022

AbstractGenital outflow tract obstruction due to cervical agenesis is an uncommon Mullerian duct anomaly, increasingly being treated with conservative surgery by creation of an outflow tract by drilling or coring into the cervical remnant or by uterovaginal anastomosis. A 19-year-old woman with cervical dysgenesis in the present case underwent a successful uterovaginal anastomosis to relieve the obstructive menstrual symptoms and preserve the future reproductive function. The neouterovaginal canal was created over a mold of Foley's catheter by anastomosis anterior surface of the uterine corpus to the vaginal vault, bypassing the dysgenetic cervix and using the fibrous band of cervix as support. Normal cyclical menses were restored. Steps of the procedure are detailed in this case report.
Measles-Associated CNS Complications: A Review
Authors: Jain Reena , Aulakh Roosy 
Published: November 2022

AbstractMeasles virus infection is a common infectious disease of childhood, incidence of which is still high in developing countries. Other than the morbidity associated with the acute systemic infection, the measles virus can cause serious fatal neural complications. It can either enter the brain leading to acute encephalitis like primary measles encephalitis and acute post infectious measles encephalomyelitis or it may persist in brain cells (as mutated virus) leading to long-term neurodegenerative diseases like measles inclusion body encephalitis and subacute sclerosing pan encephalitis. The patho-clinical features, treatment, and the outcomes of these complications are different and should be identified in time for early diagnosis and management.
X-Ray and Ultraviolet Flares on AT Microscopii Observed by AstroSat
Authors: Kuznetsov A. A. , Karakotov R. R. , Chandrashekhar K. , Banerjee D. 
Published: November 2022

Abstract
We present observations of the active M-dwarf binary AT Mic (dM4.5e+dM4.5e) obtained with the orbital observatory AstroSat. During 20 ks of observations, in the far-ultraviolet (130–180 nm) and soft X-ray (0.3–7 keV) spectral ranges, we detected both quiescent emission and at least five flares on different components of the binary. The X-ray flares were typically longer than and delayed (by 5–6 minutes) with respect to their ultraviolet counterparts, in agreement with the Neupert effect. Using X-ray spectral fits, we estimated the parameters of the emitting plasma. The results indicate the presence of a hot multi-thermal corona with average temperatures in the range of ∼7–15 MK and emission measure of ∼(2.9–4.5) × 1052 cm−3; both the temperature and the emission measure increased during the flares. The estimated abundance of heavy elements in the corona of AT Mic is considerably lower than at the Sun (∼0.18–0.34 of the solar photospheric value); the coronal abundance increased during the flares due to chromospheric evaporation. The detected flares had the energies of ∼1031–1032 erg; the energy-duration relations indicate the presence of magnetic fields stronger than in typical solar flares.
Interference on the Abbott i-STAT creatinine assay caused by hydroxyurea
Authors: Paz Matt Andrew , Seegmiller Jesse 
Published: November 2022

Abstract
Serum creatinine is an important biomarker used for estimating glomerular filtration rate (eGFR). The present study was designed after a patient at our institution had a significantly elevated creatinine result taken from an i-STAT point of care test that utilizes electrochemical detection. The patient’s creatinine from the i-STAT was 3.8 mg/dL and was not consistent with their clinical history. The patient’s previous creatinine taken 2 days prior was 1.39 mg/dL and 1.27 mg/dL seven days prior. Both previous readings were measured with the Siemens Dimension Vista 1500 using a colorimetric enzymatic creatinine method. A subsequent creatinine measured on the Siemens Dimension Vista 1500 was 1.30 mg/dL. Upon chart review, the clinical team noted that the patient is taking 500 mg of hydroxyurea daily for treatment of a myeloproliferative disorder. Review of the i-STAT package insert revealed hydroxyurea as a known interfering substance and states for every 100 µmol/L hydroxyurea in the specimen, creatinine will be increased by approximately 1.85 mg/dL. Review of literature described the positive interference caused by hydroxyurea for the i-STAT creatinine and glucose assays but did not explain the mechanism of this positive interference. In order to characterize the mechanism of hydroxyurea interference, we investigated the situation further. A pool of plasma was spiked with hydroxyurea. The spiked pool was serial diluted (x2, x4, x8, x16, x32, x64, x128) to observe the creatinine results in the presence of and absence of hydroxyurea. The dilution series was analyzed using the Vista enzymatic creatinine and the Abbott i-STAT enzymatic creatinine methods. The i-STAT creatinine results show increasing creatinine concentration from interference as the concentration of hydroxyurea increased. The dilution series suggests increasing positive interference with hydroxyurea. Positive creatinine interference with hydroxyurea was not observed when analyzed on the Vista platform. Hydroxyurea is a widely used treatment for myeloproliferative disorders and also for managing sickle cell disease. Hydroxyurea is known to cause positive interference in the i-STAT enzymatic creatine method that uses electrochemical detection, with the degree of interference correlating with the concentration of hydroxyurea. The Vista colorimetric enzymatic creatinine method was not observed to have hydroxyurea interference. While both methods employ enzymatic reagent systems the final detection approach is important. Patients undergoing hydroxyurea treatment should avoid i-STAT measurement systems for creatinine.
Pulmonary Tumor Thrombotic Microangiopathy (PTTM) Caused by Metastatic Ovarian High-Grade Serous Carcinoma: A Rare Case Report and Literature Review
Authors: Fujita J , Hummel K , Xu Y 
Published: November 2022

Abstract

Introduction/Objective
Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare entity, and often diagnosed in postmortem. PTTM is usually presented as unexplained dyspnea in a patient with known or unknown history of cancer. Tumor microemboli mainly affect the pulmonary microvasculature. PTTM is resulting from coagulation cascade activation secondary to tumor microemboli induced fibrin clot formation and fibrocellular intimal proliferation.

Methods/Case Report
The patient is a 65-year-old female with past medical history of ovarian high-grade serous carcinoma, and presented to the hospital with chest pain and shortness of breath. Coronary angiography showed no new obstructive disease. Echocardiogram revealed markedly elevated right ventricular systolic pressure (65-70 mmHg), indicated pulmonary hypertension. Computed tomography of the chest revealed diffuse bilateral ground glass and solid centrilobular nodules, with no pulmonary emboli identified. She developed worsening hypoxia and expired. A lung-restricted autopsy was performed. Literature review was conducted. The important gross findings included multiple firm and red-brown nodules (approximately 0.1 cm) in bilateral lungs. Microscopic examination revealed the lung parenchyma demonstrated numerous tumor microemboli in the pulmonary arterioles and occasionally in the small arteries. The tumor microemboli consist of tumor cells with various degree of fibrin deposition and fibrocellular intimal proliferation. The tumor cells were epithelioid with moderate to marked nuclear pleomorphism, occasional cytoplasmic vacuoles, frequent apoptosis and necrosis. Immunohistochemical stains for PAX-8 and WT1 highlight the tumor microemboli. These findings are consistent with PTTM secondary to metastatic ovarian high-grade serous carcinoma. Rare cases of PTTM associated with ovarian cancer were found in PubMed.

Results (if a Case Study enter NA)
NA.

Conclusion
PTTM has poor prognosis. There are no sensitive diagnostic modalities, and majority of them are diagnosed at autopsy. We have found four reported PTTM cases caused by metastatic ovarian cancer in PubMed, including one case of clear cell carcinoma and three cases of low-grade serous carcinoma. Our current report of PTTM is associated with high-grade serous carcinoma, which is not seen in the literature. The awareness of PTTM is necessary for patients with ovarian cancer.
Intracranial Extramedullary Hematopoiesis: a Rare Entity
Authors: Morrar D , Sham S , Al-Refai R , Harshan M 
Published: November 2022

Abstract

Introduction/Objective
Extramedullary hematopoiesis (EMH) is characterized by ectopic proliferation and differentiation of hematopoietic precursor cells outside the bone marrow. In postnatal life, EMH occurs due to hematopoietic disorders, infection or advanced tumors and is usually seen in the spleen, liver, and lymph nodes. Intracranial EMH is an extremely rare entity that has been reported to be associated with hematological disorders, meningioma, subdural hematoma and pilocytic astrocytoma.

Methods/Case Report
To highlight the significance of identifying EMH as one of the differential diagnoses of brain lesions, we present a 67-year-old female with a history of headaches and generalized malaise. Her past medical history was significant for hypertension and mild anemia. As part of the headache workup, magnetic resonance imaging (MRI) of the brain showed a 3.7cm cystic mass in the right inferomedial parietal lobe with medial mural enhancement, associated with edema and mass effect. A similar 3mm left parietal lobe enhancing focus was also noted. These findings were suggestive of a hemangioblastoma. Resection of the larger mass showed a benign vascular lesion with endothelial hyperplasia without the appearance of cavernous hemangioma or vascular malformation. Foci of erythroid and myeloid precursors, and megakaryocytes were seen. Immunohistochemical stains were negative for GFAP, CK AE1/AE3 and inhibin ruling out glial neoplasms, metastatic carcinoma and hemangioblastoma. Hematopoietic cells were positive for CD45, while immature red cells were positive for E-cadherin and endothelial cells were positive for CD31, consistent with EMH. Further workup was negative for any underlying hematological disorders, resulting in the diagnosis of idiopathic intracranial EMH. The patient received intensity- modulated radiation therapy (IMRT) for her remaining left parietal lesion. After 3 months of regular follow-up, her headache and malaise significantly improved.

Results (if a Case Study enter NA)
NA.

Conclusion
To our knowledge, this is the first reported case of idiopathic intracranial EMH.
A Rare Case of Therapy Related Monoblastic Leukemia with t(8;16)(p11.2;p13.3)/KAT6A-CREBBP Fusion and Hemophagocytosis
Authors: Perveze I , Hammer R 
Published: November 2022

Abstract

Introduction/Objective
Therapy related leukemias are often myeloid and occur as a late complication of cytotoxic therapy or radiotherapy. Most common etiologies are alkylating agents and topoisomerase II inhibitors leading to inaccurate base pairing and chromosomal breakages resulting in complex karyotypes. We describe an extremely rare case of therapy related monobalstic leukemia with t(8;16)(p11.2;p13.3)/KAT6A-CREBBP Fusion and hemophagocytosis.

Methods/Case Report
An 81-year-old female with history of mixed cellularity Hodgkin’s lymphoma status post chemotherapy with AVD (Adriamycin, Vinblastine and Dacarbazine) and in remission presented with a complaint of newly developed skin rash on her chest. Punch biopsy showed a diffuse infiltrate of blastoid mononuclear cells with a component of monocytic differentiation present throughout the dermis. Complete blood count revealed bicytopenia (Hemoglobin 8.4 g/dl, platelets 32 x 109 per liter) and peripheral blood smear examination showed 54% blasts. Bone marrow biopsy was remarkable for infiltration by 79.2% blasts with monocytic differentiation and prominent hemophagocytosis. Immunophenotypic analysis was notable for weak positivity for p53 and a Ki67 proliferation index of 20%. These results led to the diagnosis of monobasic leukemia with hemophagocytosis. Cytogenetic analysis was abnormal with 19 out of 20 metaphases showing t(8;16)(p11.2;p13.3). Interestingly, FISH revealed the rare KAT6A- CREBBP fusion gene. The patient was hospitalized for induction chemotherapy and started on Decitabine. Her hospital course was complicated with acute kidney injury and pulmonary edema with rapid deterioration along with persistent elevation of blasts in the blood. The patient opted for hospice due to lack of improvement and died thereafter.

Results (if a Case Study enter NA)
NA.

Conclusion
AML with t(8,16) is an extremely rare entity accounting for 0.2 to 0.4% of AML cases. AML with t(8,16)/KAT6-CREBBP is frequently associated with monocytic or myelomonocytic differentiation, leukemia cutis and hemophagocytosis. While spontaneous remission can occur in a subset of neonatal t(8;16)(p11.2;p13.3), the majority of cases are therapy-related and carry a poor prognosis as seen in our patient.
Low availability of functional seed trait data from the tropics could negatively affect global macroecological studies, predictive models and plant conservation
Authors: Visscher Anne M , Vandelook Filip , Fernández-Pascual Eduardo , Pérez-Martínez Laura Victoria , Ulian Tiziana , Diazgranados Mauricio , Mattana Efisio 
Published: November 2022

Abstract

Background
Plant seeds have many traits that influence ecological functions, ex situ conservation, restoration success and their sustainable use. Several seed traits are known to vary significantly between tropical and temperate regions. Here we present three additional traits for which existing data indicate differences between geographical zones. We discuss evidence for geographical bias in availability of data for these traits, as well as the negative consequences of this bias.

Scope
We reviewed the literature on seed desiccation sensitivity studies that compare predictive models to experimental data and show how a lack of data on populations and species from tropical regions could reduce the predictive power of global models. In addition, we compiled existing data on relative embryo size and post-dispersal embryo growth and found that relative embryo size was significantly larger, and embryo growth limited, in tropical species. The available data showed strong biases towards non-tropical species and certain families, indicating that these biases need to be corrected to perform truly global analyses. Furthermore, we argue that the low number of seed germination studies on tropical high-mountain species makes it difficult to compare across geographical regions and predict the effects of climate change in these highly specialized tropical ecosystems. In particular, we show that seed traits of geographically restricted páramo species have been studied less than those of more widely distributed species, with most publications unavailable in English or in the peer-reviewed literature.

Conclusions
The low availability of functional seed trait data from populations and species in the tropics can have negative consequences for macroecological studies, predictive models and their application to plant conservation. We propose that global analyses of seed traits with evidence for geographical variation prioritize generation of new data from tropical regions as well as multi-lingual searches of both the grey- and peer-reviewed literature in order to fill geographical and taxonomic gaps.