bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efectos bronquiopulmonares de la histamina
Authors: Voltas F. , Mouriz Angela 
Published: October 2022

Se estudian las variaciones de distensibilidad pulmonar y resistencia en cobayos y perros, durante el efecto de la inyección intravenosa de histamina. Se comprueba que la distensibilidad disminuye aunque tal efecto puede ir precedido de un ligero y transitorio aumento. Se explica el aumento de capacidad residual funcional observado, interpretándolo como secundario a la elevación de resistencia espiratoria.
En el acceso asmático experimental, según investigaciones de Noelpp y Noelpp 18, el aumento de resistencia elástica es un factor decisivo, pero en otras investigaciones se ha podido observar que, en determinadas circunstancias, la histamina parece aumentar la distensibilidad (Casal 2). Por otra parte, nosotros llegábamos a la conclusión ele que el factor predominante en nuestras condiciones experimentales era el aumento de resistencia bronquial (Mouriz 15). Por todo esto, y pretendiendo precisar nuestros anteriores resultados, hemos creído interesante realizar estudios sistemáticos sobre distensibilidacl y resistencia durante la inyección de histamina en perros y cobayos. Realizamos ensayos con histamina por vía intravenosa porque aun cuando no reproduzca exactamente el acceso asmático auténtico, el efecto es evidentemente muy parecido, con la ventaja sobre otros métodos experimentales ele que simplifica la técnica y permite una valoración cuantitativa más segura y una mejor comparación de las experiencias en distintos animales.
Factores nutritivos en la etiopatogenia del bocio endémico
Authors: Muñoz M. 
Published: October 2022

Dentro de los factores nutritivos que pueden favorecer la endemia bociosa, se ha estudiado en 16 pueblos del norte de la provincia de Navarra, el contenido de iodo en agua y leche (Método de Benotti y Benotti), la presencia de goitrina en la semilla de nabos de una de las zonas exploradas (métodos de Greer y de Kreula y Kiesvaara), el estado nutritivo en tres pueblos, mediante encuesta (técnica de Vivanco y Palacios) y, finalmente, durante cuatro años consecutivos se ha examinado el tiroides de escolares pertenecientes a los pueblos de Labayen, Urroz de Santesteban y Saldías. Se considera que las substancias bociógenas juegan un papel importante en la aparición del bocio endémico en los pueblos donde se estudió este problema. En ellos se comprobó una mayor frecuencia de bocio coincidiendo con la época de consumo de nabos por las vacas.
El factor déficit de iodo no creemos pueda valorarse hasta no conocer el contenido de este elemento en todos los alimentos consumidos en las zonas estudiadas.
El consumo pobre de vitaminas podría dificultar la normal síntesis de la hormona tiroidea.
Necrosis suprarrenal con hemorragia
Authors: Herranz G. 
Published: October 2022

En la necropsia de una mujer afecta de lupus eritematoso diseminado se encontró que la glándula suprarrenal derecha estaba convertida en una masa necrótica y hemorrágica. El estudio histológico de ambas suprarrenales reveló un conjunto de lesiones que representan los sucesivos estadios que conducen a la necrosis con hemorragia. Estas alteraciones comienzan por la necrosis focal, de células aisladas o de pequeños grupos celulares, que deja espacios libres que son ocupados por un líquido de edema. Este puede contribuir a extender la necrosis. En esta fase lesiona! puede sobrevenir una reacción inflamatoria que, en ocasiones, termina con la constitución de un foco cicatricial fibroso. Por otra parte, como ha ocurrido en la suprarrenal derecha, las paredes endoteliales de los sinusoides, al carecer del apoyo que normalmente le prestan los cordones celulares, pueden desintegrarse dejando salir la sangre a los tejidos, resultando así la hemorragia. La necrosis celular es el fenómeno fundamental del proceso, por lo que se propone para el mismo la denominación de necrosis suprarrenal con hemorragia.
Se discute la posible relación entre la lesión descrita y la administración de ACTH con fines terapéuticos. Sobre bases experimentales y clínicas se puede concluir que el ACTH exógeno puede contribuir, en colaboración con la acción a1armígena de la enfermedad primaria, a la producción de una lesión suprarrenal del tipo descrito. Por ello es de recomendar mucha precaución en el uso de la corticotropina en ciertos tipos de enfermedades.
También se sugiere que Iesion·es similares a las descritas pueden constituir el substrato morfológico del cuadro de la insuficiencia suprarrenal yatrogénica que se manifiesta en algunos pacientes sometidos a una terapéutica con ACTH.
En los preparados histológicos procedentes de este mismo caso se encontraron rasgos representativos del fenómeno L. E. en los tejidos que son objeto de un artículo en el mismo número de esta Revista.
CONCEITO DE PRIVAÇÃO MATERNA NA TEORIA DE JOHN BOWLBY: IMPACTOS NA EDUCAÇÃO INFANTIL
Authors: Neder Kaira , Amorim Katia de Souza 
Published: October 2022

A tessitura deste trabalho almejou a construção de um panorama acerca da emergência da Teoria do Apego de John Bowlby, particularmente quanto à noção de separação da criança pequena da figura materna e aos efeitos deletérios daquela para o desenvolvimento socioemocional na primeira infância. Nesta perspectiva, o texto buscou elucidar o contexto histórico de emergência desse conceito, assim como suas repercussões para os campos que se ocupam dos estudos sobre a infância, em especial a Educação Infantil. Para tal, concebeu-se esse texto em três partes. Primeiramente, será abordado o histórico da “descoberta da infância” e do consequente centramento da família na criança e de “governos da infância” postos ao encargo da mãe. Em um segundo momento, caminharemos em direção aos escritos bowlbyanos, particularmente a partir da leitura dos primeiros dois volumes da trilogia “Apego e Perda” e do relatório elaborado por ele para a Organização Mundial de Saúde (OMS), em 1951. Seguindo esse fluxo, em uma terceira parte, tratar-se-á da proporção que essa teoria tomou: sua difusão em termos de políticas públicas em diferentes culturas e do caráter quase dogmático - com sérias implicações - de seus preceitos que foram encampados em áreas como a Psiquiatria Infanti, Psicologia do Desenvolvimento e Pedagogia.
EDUCAÇÃO INCLUSIVA EM UMA PERSPECTIVA FREIRIANA
Authors: Da Silva Lucélio Ferreira , Carvalho Martha Milene Fontenelle , Xavier Mércia Maria Peixoto , Milagres Nilma Vieira 
Published: October 2022

Resumo Este artigo tem como abordagem uma breve discussão sobre o livro de Paulo Freire, Pedagogia do oprimido (1987), e sua influência enquanto uma proposta para pensar a inclusão escolar, permeando a relação dos conceitos de opressor e oprimido e a inclusão/exclusão de pessoas com deficiência. O presente trabalho justifica-se pela necessidade de promover debates e a análise de textos que contribuíram para a libertação do excluído e do oprimido. Percebemos, nesse processo, grandes contribuições na perspectiva da educação no âmbito social, cultural e inclusiva. Este artigo é uma pesquisa de cunho qualitativo, tendo como metodologia uma análise de caráter bibliográfico, formando uma reflexão com a prática educativa que possibilite e contribua com a inclusão e libertação do excluído/oprimido. Palavras – Chave: Inclusão, oprimido, pessoas com deficiência. Abstract This article has as approach a brief discussion about Paulo Freire’s book, Pedagogia do oprimido (1987), and its influence as a proposal to think about school inclusion, which permeates the relation between the concepts of oppressor and oppressed and the inclusion/exclusion of people with disabilities. The present work justifies its existence by the need to promote debates and the analysis of texts that have contributed to the liberation of the excluded and the oppressed. We perceived, in this process, great contributions from the perspective of education in the social, cultural and inclusive sphere. This article is a qualitative research, it has a methodology based on a bibliographic analysis, forming a reflection that enables and contributes to the inclusion and liberation of the excluded/oppressed. Key-words: Inclusion, oppressed, people with disabilities.
Pengembangan kualitas dan keunggulan kepemimpinan dalam organisasi: peran moderasi nilai-nilai kearifan lokal
Authors: Sahertian Pieter , Jawas Umiati , Kodrat David Sukardi 
Published: October 2022

Various research results show that everything that is expected of a leader, what a leader can and cannot do, as well as the status and influence exerted by a leader is the result of the culture in the country where the leader performs his function. Therefore, to be an effective leader one must have the capacity that is obtained through developing leadership skills in the social context in which he is located. This study aims to analyze the effect of developing leadership skills and local wisdom values in forming leadership excellence in Indonesia. The research method used quantitative. The research sample was the leaders of Javanese, Sundanese, Betawi, Minang, Bugis, Batak, Madurese, Balinese, Banjar, Menado, Mataram, Flores and Papuan ethnic groups with a total of 710 respondents. A cluster and purposive sampling technique were used because the leaders as the unit of analysis were grouped into clusters based on ethnicity and region and then the leaders who were selected based on the objectives of the study. SEM analysis was used to data analysis and hipothesis testing. This study shows that the development of leadership abilities and local wisdom values can significantly increase the dimensions of leadership excellence. Besides, the values of local wisdom are able to moderate the influence of developing leadership abilities on leadership excellence.
Race/Ethnicity-Specific Associations Between Breastfeeding Information Source and Breastfeeding Rates among U.S. Women
Authors: Quintero Stephanie , Strassle Paula D. , Tobón Amalia Londoño , Ponce Stephanie , Alhomsi Alia , Maldonado Ana I. , Ko Jamie S. , Wilkerson Miciah J. , Nápoles Anna María 
Published: October 2022

Abstract
Objectives.
To assess race/ethnicity-specific associations between breastfeeding information sources and breastfeeding initiation and duration.
Methods.
We used data from the 2016–2019 Pregnancy Risk Assessment Monitoring System. Race/ethnicity-stratified multinomial logistic regression was used to estimate associations between information source (e.g., family/friends) and breastfeeding rates (0 weeks/none, < 10 weeks, or ≥ 10 weeks). All analyses were weighted to be nationally representative.
Results.
Among 5,945,018 women (weighted), 88% reported initiating breastfeeding (≥ 10 weeks = 70%). Information from family/friends (< 10 weeks: aORs = 1.58–2.14; ≥10 weeks: aORs = 1.63–2.64) and breastfeeding support groups (< 10 weeks: aORs = 1.31–1.76; ≥10 weeks: aORs = 1.42–2.77) were consistently associated with breastfeeding initiation and duration across all racial/ethnic groups; effects were consistently smaller among Alaska Native, Black, and Hispanic women (vs White women). Over half of American Indian and one-quarter of Black women reported not initiating/stopping breastfeeding due to return to school/work concerns.
Conclusions.
Associations between breastfeeding information source and breastfeeding rates vary across race/ethnicity. Culturally tailored breastfeeding information and support from family/friends and support groups could help reduce breastfeeding disparities. Additional measures are needed to address disparities related to concerns about return to work/school.
Student Perspectives on the Use of Universal Design for Learning in Virtual Formats in Higher Education
Authors: Wells Melissa 
Published: October 2022

Abstract
Universal Design for Learning (UDL) in higher education may be a useful tool in supporting the heterogenous higher education student population, specifically in supporting student academic outcomes and retention. Using survey responses of undergraduate degree-seeking students, this mixed-methods study explored the students’ perceptions and impact of UDL in virtual learning modalities (online courses, independent studies, and virtual study groups). Participants used a Likert-type survey to assess the student-reported prevalence of UDL techniques in higher education in various virtual learning modalities. Students also discussed the strategies that impacted their experience as learners and the mode of study in which they felt most successful. Implications for practice and research are also presented.
The investigation of resting-state functional connectivity of pulvinar in old age individuals and Parkinson’s patients
Authors: Velioglu Halil Aziz , AYYILDIZ BEHCET , AYYILDIZ SEVILAY , Sutcubasi BERNIS , Hanoglu Lutfu , Bayraktaroglu Zubeyir , Yildirim Suleyman , Sakul Ufuk , Yulug Burak 
Published: October 2022

Abstract
The pulvinar is largest thalamic nucleus and has been subdivided into anterior pulvinar (PuA), inferior pulvinar (PuI), medial pulvinar (PuM) and, lateral pulvinar (PuL). Although the function of pulvinar is well known, its role in neurodegenerative diseases is still unclear. We aimed to examine the functional connectivity of PuA, PuI, PuM and, PuL in healthy controls (HC) and patients with Parkinson’s disease (PD). Resting-state fMRI and T1 weighted images of 15 healthy control (HC), and 12 PD patients were used in this study. SPM12 and CONN software were used to preprocessing the imaging data using published pipelines. Seed based resting-state fMRI analyses were carried out to compare the functional connectivity changes between groups. Besides, voxel-based morphometry (VBM) analysis was performed to compare gray matter volume differences between two groups. The bilateral PuI, PuL and PuM exhibited a decreased functional connectivity in the PD group compared to the HC group in the bilateral thalamus, posterior cingulate cortex, cerebellum, and brainstem. Moreover, pulvinar nuclei in each hemisphere had significantly smaller volume in the patients with PD compared to HC. This study highlights that the patients with PD have a smaller volume in pulvinar nuclei in each hemisphere compared to HC. The pulvinar showed less connectivity in the PD group compared to the HC, the diminished connectivity may be associated with hallucination, executive function, and working memory dysfunctions in PD.
Fenton reagent oxidation treatment of nitropyrazole wastewater
Authors: Ming Liu , Shuai ZHANG , Rushui ZHENG , Linxiu ZHAO , Duanlin CAO , Fanfan SHENG , Yongxiang LI 
Published: October 2022

Abstract
In this paper, Fenton reagent was used to oxidize 3,4-dinitropyrazole wastewater, and the effects of FeSO4•7H2O dosage, H2O2 dosage, initial pH, reaction time and reaction temperature on the treatment effect were studied.The results show that the oxidation of Fenton reagent can effectively remove 3,4-dinitropyrazole from nitropyrazole wastewater. When the dosage of FeSO4•7H2O is 13.2g•L− 1 and the dosage of H2O2 is 82mL•L− 1. When the initial pH is 2, the reaction time is 120min and the reaction temperature is 30℃, the removal rate of 3,4-dinitropyrazole in the wastewater reaches 97%, and the removal rate of COD reaches 62.9%;The reaction kinetics study showed that the degradation of 3,4-dinitropyrazole in the reaction process conformed to the second-order kinetic model;UV-Vis absorption spectrum analysis showed that the absorbance of wastewater samples before and after treatment decreased significantly.After the Fenton oxidation treatment, the water quality of the wastewater changed and the biodegradability of the wastewater was significantly improved.
An estimation of the endoscopist's musculoskeletal injury risk for right and left lateral decubitus positions during colonoscopy: a field-based ergonomic study (S197)
Authors: Landry Maxim , Mackey Sarah , Hossain Intekhab , Fairbridge Nicholas , Greene Alison , Borgaonkar Mark , Cullen Kimberley , Pace David , De Carvalho Diana 
Published: October 2022

Abstract
Background
Colonoscopy exposes endoscopists to awkward postures and prolonged forces, which increases their risk of musculoskeletal injury. Patient positioning has a significant impact on the ergonomics of colonoscopy. Recent trials have found the right lateral decubitus position is associated with quicker insertion, higher adenoma detection rates, and greater patient comfort compared to the left lateral decubitus position. However, this patient position is perceived as more strenuous by endoscopists.
Methods
Nineteen endoscopists were observed performing colonoscopies during a series of four-hour endoscopy clinics. Durations of each patient position (right lateral decubitus, left lateral decubitus, prone, and supine) were recorded for all observed procedures (n = 64). Endoscopist injury risk was estimated by a trained researcher for the first and last colonoscopies of the shifts (n = 34) using Rapid Upper Limb Assessment (RULA), an observational ergonomic tool that estimates risk of musculoskeletal injury by scoring postures of the upper body and factors such as muscle use, force, and load. The total RULA scores were compared with a Wilcoxon Signed-Rank test for patient position (right and left lateral decubitus) and time (first and last procedures) with significance taken at p < 0.05. Endoscopist preferences were also surveyed.
Results
The right lateral decubitus position was associated with significantly higher RULA scores than the left lateral decubitus position (median 5 vs. 3, p < 0.001). RULA scores were not significantly different between the first and last procedures of the shifts (median 5 vs. 5, p = 0.816). 89% of endoscopists preferred the left lateral decubitus position, primarily due to superior ergonomics and comfort.
Conclusion
RULA scores indicate an increased risk of musculoskeletal injury in both patient positions, with greater risk in the right lateral decubitus position.
Role of chest CT scan in patients with preexisting cancer and COVID-19 Pneumonia
Authors: Khorasanizadeh Faezeh , Kaviani Soori , Salamroudi Shadi , SadatSeyedsalehi Monireh , Gity Masoumeh , Zendehdel Kazem 
Published: October 2022

Abstract
Background: Detection of COVID-19 in cancer patients is challenging due to probable preexisting pulmonary infiltration caused by many infectious and non-infectious etiologies. We evaluated chest CT scan findings of COVID-19 pneumonia in cancer patients and explored its prognostic role in mortality.
Methods: We studied 266 COVID-19 patients with a history of cancer diagnosis between 2020 and 2022. Chest CT images were reported based on Radiological Society of North America (RSNA) structural report and the CT score and pattern of involvement were noted. We used multivariate logistic regression models to determine the association between CT scan findings and mortality of the cancer-COVID-19 patient.
Results: The mean age was 56.48 (±18.59), and 53% were men. Gastrointestinal (29.3%), hematologic (26.3%), and breast (10.5%) cancers were the most frequent types of cancer. The prevalence of atypical or indeterminate findings in the chest CT was 42.8%. Most radiologic findings were consolidation mixed with ground-glass opacity (44.4%), pleural effusion (33.5%), and pure ground-glass opacity (19.5%). The risk of death was higher among those who had typical chest CT for COVID-19 (OR=3.47; 95% CI 1.14-8.98) and those who had a severity of score higher than 18 (OR=1.89, 95% CI 1.07-3.34). Also, presence of consolidation (P-value: 0.04), pleural effusion (P-value: 0.000), centrilobular nodules (P-value: 0.013) and architectural distortion (P-value: 0.005) were associated with a poorer prognosis.
Conclusion: Less than half of COVID-19 patients with a history of cancer had typical imaging features of COVID-19. Radiologists should be aware of atypical, rare, or subtle chest CT findings in patients with pre-existing cancer.
Do we properly quantify P from Mehlich 1 or Mehlich 3 extracting solutions?
Authors: Pogorzelski Denison , Santos Wedisson Oliveira , Pimentel Gabriel Grossi , Matias Patrícia Cardoso , Vergutz Leonardus , Ballotin Fabiane Carvalho 
Published: October 2022

Abstract
Aims
The performance of colorimetric methods for P quantification is usually overlooked by researchers and not suitable to errors. Here, we investigated the performance of two blue colorimetric methods for P quantification, Braga & Defelipo (1974) (B&D) and Murphy & Riley (1962) (M&R), using two commonly soil P extractants, Mehlich-1 (M1) and Mehlich-3 (M3).
Methods
Specifically, we evaluated the color development time and its stability in different soil extractant solution proportions (1:1 or 1:4 v/v), the optimum wavelength, limits of detection and element quantification.
Results
Our results indicate that M3 leads to lower limits of detection and quantification for both colorimetric methods, particularly for B&D. For M1, the volumetric ratio (1:1 or 1:4) did not influence color development and both B&D and M&R methods showed a fast color development. However, B&D showed greater color stability (from 5 to 600 min) and an optimum wavelength of 711 nm, while M&R was stable from 27 to 600 min an optimum wavelength of 889 nm. For M3 soil extractant, there are important issues, such as M&R being unstable and B&D presenting slow color development. In addition, the spectral profile obtained from soil extractant was different from the one obtained by the calibration curve without soil for both M&R and B&D.
Conclusions
Therefore, the adoption original methods on P quantification in M3 extracting solution represents a potential source of error, leading to wrong P fertilizer recommendations. Thus, the best option for P quantification in M3 extracts seems to be the use of ICP.
Acetyl-acetyl-L-leucine for Niemann-Pick type C: a multinational double-blind randomized placebo-controlled crossover study
Authors: Fields Taylor , Bremova-Ertl Tatiana , Billington Ian , Churchill Grant , Evans William , Fields Cassandra , Galione Antony , Kay Richard , Matheison Toni , Martakis Kyriakos , Patterson Marc , Platt Frances , Factor Mallory , Strupp Michael 
Published: October 2022

Abstract
Background
Niemann-Pick disease type C (NPC) is a rare autosomal recessive neurodegenerative lysosomal disease characterized by multiple symptoms such as progressive cerebellar ataxia and cognitive decline. The modified amino acid N-acetyl-leucine has been associated with positive symptomatic and neuroprotective, disease-modifying effects in various studies, including animal models of NPC, observational clinical case studies, and a multinational, rater-blinded Phase IIb clinical trial. Here, we describe the development of a study protocol (Sponsor Code “IB1001-301”) for the chronic treatment of symptoms in adult and pediatric patients with NPC.
Methods
This multinational double-blind randomized placebo-controlled crossover Phase III study will enroll patients with a genetically confirmed diagnosis of NPC patients aged 4 years and older across 16 trial sites. Patients are assessed during a baseline period and then randomized (1:1) to one of two treatment sequences: IB1001 followed by placebo or vice versa. Each sequence consists of a 12-week treatment period. The primary efficacy endpoint is based on the Scale for the Assessment and Rating of Ataxia, and secondary outcomes include cerebellar functional rating scales, clinical global impression, and quality of life assessments.
Discussion
Pre-clinical as well as observational and Phase IIb clinical trials have previously demonstrated that IB1001 rapidly improved symptoms, functioning, and quality of life for pediatric and adult NPC patients and is safe and well tolerated. In this placebo-controlled cross-over trial, the risk/benefit profile of IB1001 for NPC will be evaluated. It will also give information about the applicability of IB1001 as a therapeutic paradigm for other rare and common neurological disorders.
Trial registrations:
The trial (IB1001-301) has been registered at www.clinicaltrials.gov (NCT05163288) and www.clinicaltrialsregister.eu (EudraCT: 2021-005356-10).