bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthopaedic Society Leadership Diversity and Academic Participation
Authors: Albright Patrick , Banks Evan , Wood Lily , Chambers Caitlin , Van Heest Ann 
Published: July 2022

Background:
In the United States, female and minority representation in the field of orthopaedic surgery remains low, and there are few reports regarding orthopaedic society leadership composition, selection criteria, and academic participation. We aimed to determine the demographic composition of national orthopaedic societies and report the academic participation metrics of leadership.

Methods:
This was a mixed-methods study using surveys and publicly available data from national orthopaedic societies for the 2020 to 2021 year. Twenty-four orthopaedic society websites were queried for their transparency in leadership selection and demographic information, including sex, racial, and ethnic composition of overall society and board membership. Data were collected regarding the academic participation of board leadership.

Results:
In total, 19 (79%) of the 24 national orthopaedic societies publish survey data regarding sex and racial demographics. One society elected not to participate, and there was no response from 4 others. Sixteen (89%) of the societies collect sex-related data from their membership, and 19 (100%) report sex-related data for their board members. Five (28%) collect data regarding the race and ethnicity of their general membership, and 10 (53%) report data regarding the race and ethnicity of board members. The average membership was 89% male and 11% female, and the leadership boards were 86% male and 14% female. In the societies that reported on race and ethnicity, on average, 80% of the members were White and 85% of the board members were White. Few societies (13%) publicly list their presidential nominating criteria, and none list their criteria for nonpresidential-line positions. Female sex and ≤10 years in practice were significantly associated with lower Hirsch index (h-index) scores, but these differences dissipated beyond 10 years.

Conclusions:
There is a lack of sex, racial, and ethnic diversity in orthopaedic society leadership. More robust recording of these data by societies can help track improvements in diversity among members and leaders. Academic participation may be one component of leadership selection, but other factors play an important role. Overall transparency of leadership selection criteria could be clarified among orthopaedic societies.
Amyloid Deposition: An Unusual Case of Deep Gluteal Syndrome and Sciatic Nerve Compression
Authors: Parikh Harin B. , Matcuk George R. , Leong Matthew , Vrahas Mark S. , Seruya Mitchel 
Published: July 2022

Case:
Soft-tissue amyloidomas are exceedingly rare, with only a few cases reported in the literature. There are no reports of sciatic nerve compression secondary to a soft-tissue amyloidoma. We report a unique case of a 71-year-old man with an incidentally found amyloidoma who was initially believed to have deep gluteal syndrome. He had a favorable outcome after surgical decompression.

Conclusion:
For patients who do not have classic examination and electromyography/nerve conduction findings of piriformis syndrome, providers should explore other etiologies of peripheral nerve compression including soft-tissue amyloidoma.
Modified Live Attenuated Influenza B Virus Vaccines and Sex-driven Differences on Humoral Immune Responses in the DBA/2J Mouse Model
Authors: Perez Daniel , Garcia Stivalis Cardenas , Caceres C. Joaquin , Jain Aarti , Geiger Ginger , Mo Jong-Suk , Gay L. Claire , Seibert Brittany , Jasinskas Algis , Nakajima Rie , Rajão Daniela , Davies Huw 
Published: July 2022

Abstract
Influenza B virus (FLUBV) is a major respiratory pathogen of humans. Seasonal influenza vaccines include either one or both FLUBV lineage strains, Victoria, and Yamagata. Vaccine mismatch occurs frequently, particularly in countries where vaccines contain only one of the lineages. We have previously described the safety and efficacy of modified live attenuated FLUBV vaccines based on either virus with rearranged genomes (FluB-RAM and FluB-RANS) or carrying a PB1 segment with a combination of temperature sensitive mutations and a C-terminal HA tag (FluB-att). We compared side by side the immunological responses in female and male DBA/2J mice vaccinated with either one of these vaccines and those with isogenic backbones containing a chimeric HA segment carrying an N-terminal IgA inducing peptide (IGIP). Recombinant viruses with or without the IGIP modification were genetically stable over multiple passages in eggs. In mice, introduction of IGIP improved attenuation of the vaccine candidates, particularly for the FluB-RAM/IGIP compared with the non-IGIP FluB-RAM counterpart. In a prime-boost regimen, mice were completely protected against lethal challenge with a homologous FLUBV strain. Recombinant viruses induced neutralizing antibodies with hemagglutination inhibition titers ≥40. Antibodies against NA and NP were readily detected. Compared to male mice and regardless of the vaccine used, female mice showed a clear trend towards enhanced humoral and cross-reactive IgG and IgA anti-HA responses as well as against NA and NP. The presence of IGIP in the vaccine resulted in an overall trend towards reduced anti-HA responses but enhanced anti-NA and anti-NP responses, particularly of the IgA isotype. Mucosal and serological responses two weeks after challenge showed similar trends with clear differences observed based on sex, vaccine backbone, and whether the vaccine carried the IGIP modification. These findings are significant for the development of universal influenza vaccines.
Coordination of bladder peripheral clock and diurnal micturition pattern by glucocorticoids
Authors: Chihara Ichiro , Negoro Hiromitsu , Kono Jin , Nagumo Yoshiyuki , Tsuchiya Haruki , Kojo Kosuke , Shiga Masanobu , Tanaka Ken , Kandori Shuya , Mathis Bryan , Nishiyama Hiroyuki 
Published: July 2022

Abstract
Peripheral clocks function to regulate each organ and are synchronized though various molecular and behavioral signals. However, signals that entrain the bladder clock remain elusive. Here, we show that glucocorticoids are a key cue for the bladder clock in vitro and in vivo. A pBmal1-dLuc human urothelial cell-line showed significant shifts in gene expression after cortisol treatment. In vivo, rhythmic bladder clock gene expression was unchanged by bilateral adrenalectomy but shifted 4 hours forward by corticosterone administration at the inactive phase. Moreover, the bladder clock shifted 8–12 hours in mice that underwent both bilateral adrenalectomy and corticosterone administration at the inactive phase. These mice saw decreases in the diurnal rhythm of volume voided per micturition, while maintaining diurnal activity rhythms. These results indicate that the diurnal rhythm of glucocorticoid signaling is a zeitgeber that overcomes other bladder clock entrainment factors and coordinates the diurnal rhythm of volume voided per micturition.
WITHDRAWN: Prognostic impact of the expression of NK cell receptor NCR3, CD28 and PD-1 molecular on T cell in peripheral blood of advanced breast cancer patients undergoing paclitaxel chemotherapy
Authors: Yang Ji , Qu Shuxian , Qi Xinhui , Liu Yongming , Qiu Jianing , Yu Ying , Zheng Zhendong , Yu Huiying 
Published: July 2022

Abstract
Background
The main goals of treatment for advanced breast cancer were to prolong survival and improve quality of life. Paclitaxel is a commonly used chemotherapy drug for advanced breast cancer. The occurrence and development of tumors largely depend on the functional state of the immune system. NK cells and T cells are the two main cell subsets who play a key role in tumor immune surveillance and anti-tumor. Their functions mainly depend on the expression of receptors on their surface. This study mainly investigated the correlation between the expression levels of NK cell activating receptors and CD28 and PD-1 molecules on T cells in peripheral blood with prognosis in patients with advanced breast cancer undergoing paclitaxel chemotherapy.
Methods
Peripheral blood was detected by flow cytometry for immunophenotype and PCR technology for detection of NCR transcripts from 53 patients with advanced breast cancer. To compare the differences in immunophenotype and NCR3 transcripts among breast cancer patients with different molecular types. The correlation between immunophenotype and NCR3 splice isomer expression with tumor load, chemotherapy sensitivity to paclitaxel and survival were further analyzed.
Results
The ratio of CD28+/CD28− T cells and NCR3 transcript expression in peripheral blood of triple-negative breast cancer patients was higher than that of patients in other groups. Elevation of NCR3 transcripts mainly inhibits NKp30c. NKp30 on NK cells, NCR3 transcripts, the proportion of CD4+CD28− T cells and PD-1 on T cells were positively correlated with tumor burden in patients. The proportion of CD4+CD28+ T cells was negatively correlated with the tumor burden in patients. After paclitaxel chemotherapy, patients with high expression of CD28 and low expression of PD-1 on T cells before paclitaxel chemotherapy were more sensitive to chemotherapy; patients with low expression level of NKp30 inhibitory splice isomer in NK cells and high ratio of CD28+/PD-1+ T cells before paclitaxel chemotherapy had better PFS.
Conclusion
The expression of NCR3 in NK cells and the expression of CD28 and PD-1 molecules on T cells can be used as potential biomarkers for evaluating tumor progression, chemotherapy effect and prognosis in patients with advanced breast cancer.
A Design of 45nm Low Jitter Charge Pump Phase-Locked Loop Architecture for VHF and UHF Fields
Authors: Ton That Bao Phuc , Dang Cong Thinh , Hoang Trang 
Published: July 2022

Abstract

Phase-locked loop has contributed significantly toward the technological advancement in data transmission and communication. In addition, many recent studies in Phase-locked loop schemes combined with novel integrated circuit technology have made Phase-locked loop devices become essential system components. This work designed a Phase-locked loop with an input voltage of 1.0V, which is researched on the 45nm NCSU PDK with Cadence Virtuoso tools to gain output frequency over 800MHz and low jitter of 150ps. Furthermore, the proposed procedure uses Ocean language to analyze the variation of Phase-locked loop parameters in this work, including output voltage, operating frequency, and phase jitter.
Research on the differentiation of residents’ cultural consumption tendency and consumption recommendation system based on network inference algorithm
Authors: Lian Naiyu , Xu Hengzhe , Zhang Feiyang 
Published: July 2022

Abstract

In order to solve the problem of insufficient accuracy of consumer recommendation systems, the study proposes to design a new network inference algorithm with bias based on the traditional network inference algorithm. Then the performance of this algorithm is verified by means of comparison experiments with NBI, SNBI and HNBI algorithms. The results show that the new network inference algorithm has an accuracy rate of 24.5%, which is better than the traditional network inference algorithm. In terms of the constituted system performance test, the recommendation hit rate of the novel network inference algorithm increases by 13.97%, which is better than NBI, SNBI, and HNBI. the experimental results indicate that the novel network inference algorithm with bias can improve the performance of the consumer recommendation system, which provides a new idea for the performance improvement of the consumer recommendation system.
WITHDRAWN: The effect of longterm hemodialysis in chronic kidney disease on macular and optic nerve head vasculature as detected by OCTA
Authors: Marrie Ayah , ElShazly Malak I , Salama Marwa M 
Published: July 2022

Abstract
Background: The relation between the kidney disease and the eye has always been a subject of interest, their anatomical, developmental and genetic similarity, suggests the link between the kidney and eye diseases, also they share the same predisposing factors like diabetes, hypertension, oxidative stress and smoking. Chronic kidney disease is one of the known causes of retinopathyPurpose: To evaluate the effect of duration of longterm hemodialysis in chronic kidney disease (CKD) patients on the macular and optic nerve vasculature using optical coherence tomography angiography (OCTA). Methods: This cross-sectional observational study included 36 eyes of 36 patients with CKD on longterm hemodialysis of different durations of onset. We correlated the vessel density in the macula in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) and optic nerve head in the radial peripapillary capillary plexus (RPC) using OCTA to the duration of onset of longterm hemodialysis in these patients and to their laboratory findings as urea reduction ratio, urea level, creatinine and blood pressure.Results: Mean duration of hemodialysis was 6.11± 2.93 years. A negative correlation between the duration of hemodialysis and vessel density of the macular SCP and DCP and optic nerve head RPC, with statistical significance in SCP in PeriFoveal section (p, 0.045), RPC Inside Disc (p, 0.022) and in the RPC average Peripapillary area (p, 0.049). The correlation between the vessel density and the URR was positive, and with statistical significance in the SCP in PeriFoveal section, RPC average Peripapillary and Inside disc vessel density but a negative correlation has been found between the URR and the DCP Parafoveal section with no statistical significance.Conclusion: The macular SCP and DCP vessel density and optic nerve head RPC vessel density decrease with increase in the duration of longterm hemodialysis in chronic kidney disease (CKD) patients.
Construct validity of the Centre for Epidemiologic Studies Depression Scale Revised – Vietnamese Version (CESDR-V) among adolescents
Authors: Tran Thach , Nguyen Huong , Shochet Ian , Nguyen Nga , La Nga , Wurfl Astrid , Orr Jayne , Nguyen Hau , Stocker Ruby , Fisher Jane 
Published: July 2022

Abstract

This study aimed to establish evidence of the construct validity of the Centre for Epidemiologic Studies Depression Scale Revised – Vietnamese Version (CESDR-V) and a 10-item version of this scale (CESDR-V-10) for use among Vietnamese adolescents. We selected 1084 Grade 10 students in Hanoi using a multiple-stage sampling method. Data supported that the CESDR-V was unidimensional. Cronbach’s alpha coefficient of CESDR-V was 0.92 and CESDR-V-10 was 0.90. All levels of measurement invariance between male and female participants for both CESDR-V and CESD-V-10 were supported well. Both CESDR-V and CESDR-V-10 were positively correlated with Depression Anxiety and Stress Subscales (DASS21)-Depression subscale at stronger levels (convergent pattern) than with DASS21-Anxiety /DASS21-Stress subscales (discriminant pattern). CESDR-V and CESDR-V-10 were negatively correlated with Mental Health Continuum Short Form (a measure of mental well-being) at lower levels than with the DASS21 subscales (discriminant pattern). This study strongly supports the use of the CESDR-V and CESDR-V-10 to screen for depression in Vietnamese adolescents who are attending school.
A Study of Nodular Skin Lesions with Special Reference to the Ethnic Population of Northeast India in a Tertiary Care Hospital
Authors: Paul Sanchita , Kalita Abhijit , Kaushik Neha 
Published: July 2022

Background: Nodular skin lesions vary significantly in size and colour/pigmentation. Most of these clinically resemble soft tissue lesions. Histopathology plays key role in categorizing the lesions based on which course of treatment is planned. The present study aims to find out incidence and variation of skin nodules and correlate the clinico-pathological details with special reference to ethnic population of Northeast India.
Methods: The study is a retrospective and descriptive study conducted for a period of 2 years at a tertiary care centre. The clinical and demographic details were retrieved and H&E slides are studied for histomorphology.
Result: A total of 50 cases were studied out of which five cases were diagnosed as malignant tumours and 45 cases were diagnosed as benign tumours. Seventeen cases (34%) of tumours with follicular differentiation, eight cases (16%) of melanocytic tumours, nine cases (18%) of vascular and neural tumours, thirteen cases (26%) of tumours with apocrine and eccrine differentiation, two cases (4%) of epidermal tumors and one case (2%) of tumour with sebaceous differentiation were included under the present study. Tumors with follicular differentiation, the most commonly encountered tumor in the present study, were seen in the fourth to sixth decades of life and seen more commonly among women. A total of 18 (36%) cases belonged to ethnic tribal communities of North-east India, out of which seven were tumors of follicular differentiation, five were melanocytic tumours and six were tumors of eccrine differentiation.
Conclusion: H&E-stained sections stand as the most important tool for diagnosing and differentiating skin nodular lesions. A significant percentage (36%) of the lesions in the present study have been seen in the ethnic population of the Northeast region of India.
Analysis of vitamin D availability of premature infants in the south of Russia
Authors: Verisokina N. E. , Kuryaninova V. A. , Petrosyan M. A. , Zakharova I. N. , Zaplatnikov A. L. , Zubkov V. V. , Klimov L. Ya. , Dmitrieva D. V. , Beketova N. Yu. , Momotova A. A. 
Published: July 2022

Introduction. Inadequate vitamin D supply worldwide is a public health problem. Low vitamin D levels during pregnancy can lead to abnormal placentation, placental insufficiency and abnormal fetal development, which contributes to poor health after birth.Objective of the study is to analyze the vitamin D status of premature infants born in the south of Russia.Materials and methods. A total of 141 premature infants were examined. Extremely low birth weight was found in 19 (13.4%) newborns, very low birth weight in 35 (24.8%), and low birth weight in 75 (53.2%).Results and discussion. Premature infants had vitamin D deficiency in the majority of cases (51%), with a median of 16.9 [11.7; 22.9] ng/mL. Correlation analysis demonstrated a positive association between 25(OH)D levels and body weight in very low birth weight infants (r = 0.34, p = 0.043). Serum vitamin D concentrations were 1.6 times lower in infants whose mothers did not receive multivitamins than in those whose mothers received multivitamins, 13.8 [9.7; 20.9] and 21.6 [16.9; 28.6] ng/mL, respectively (p = 0.001). Infants with an Apgar score of 7-10 had higher vitamin D levels, 17.8 [11.9; 22.7] ng/mL, than infants with severe asphyxia, 13.8 [9.9; 16.8] ng/mL (p = 0.036). Premature infants with congenital infection had lower 25(OH)D levels than infants without an infectious process, 15.6 [10.8; 22.9] and 18.4 [14.2; 22.7] ng/mL, respectively. Children with an infectious process that subsequently ended in death had lower 25(OH)D levels than children without an infectious process (p = 0.001). Children with cerebral ischemia had lower 25(OH)D concentrations than children without cerebral ischemia (p = 0.001).Conclusions. Premature infants born in the south of Russia have vitamin D deficiency in more than half of the cases. Administration of preparations containing cholecalciferol reduces the proportion of newborns with severe vitamin D deficiency, but does not ensure optimal serum levels. Initially low levels of 25(OH)D can be considered as an unfavorable prognostic sign against the background of the development of congenital infection.
New realities of chickenpox
Authors: Zakirova A. M. , Tambova N. A. , Samorodnova E. A. , Lazareva O. M. , Ivanova N. V. 
Published: July 2022

Introduction. The causative agent of chickenpox is ubiquitous. In children, especially with a burdened premorbid background, there is a high incidence of severe forms and complications.Aim. To study the course of chickenpox in children in modern conditions.Material and methods. 58 pediatricians (group 1), 42 parents of children aged 0 to 3 years (group 2) and 43 parents of children aged 3 to 6 years (group 3) were surveyed.Results and discussion. In the 1st group, 224 children (73.68%) had a long period of rashes, 57 children (18.75%) had a mild and not long period. At the age of 16, unvaccinated children first fell ill with chickenpox. In 23 patients (7.57%), there were obvious clinical manifestations of chickenpox with a pronounced and prolonged intoxication syndrome. In 67.43%, a positive Mantoux test was recorded with an increase in papule and corolla of hyperemia in dynamics. The development of complications significantly more often (p = 0.0429) was recorded in the group of children with aggravated premorbid background. All pediatricians are positive about vaccination. In the 2nd group, out of 37.5% of parents who are against vaccination, 16.67% believe that the vaccine does not always have a positive effect on the health of the child. The ineffectiveness of vaccines is recognized by 45.83% of respondents. 40.47% of children have not been vaccinated and they do not have vaccination certificates. In the 3rd group, 32.56% of children were ill with chickenpox, of which 79.07% had a mild form of the disease. 67.44% have a positive attitude towards vaccination against chickenpox. The coverage of all vaccines according to the National calendar was 100%.Conclusion. Chickenpox is a serious unsafe infectious disease that requires specific prophylaxis.
New devices to control fever in children with COVID-19 and other acute respiratory infections
Authors: Zakharova I. N. , Osmanov I. M. , Berezhnaya I. V. , Sugian N. G. , Maykova I. D. , Samitova E. R. , Kolushkin D. S. , Pupykina V. V. , Rodionov I. E. 
Published: July 2022

Introduction. When performing thermometry, different measuring instruments can be used: from contact individual to remote. Doubts about the accuracy of the measurements obtained arise in the course of severe infections, impaired general well-being, a feeling of fever, headache.The aim of the study was to evaluate the effectiveness of daily monitoring of body temperature in children with COVID-19 coronavirus infection and other acute respiratory viral infections using a medical thermograph designed to graphically display the dynamics of changes in the child's body temperature during the day to monitor its variability, compared to a halystone thermometer.Materials and methods. The clinical study was performed at two clinical sites of the Academician G.N. Speransky Department of Pediatrics, Russian Medical Academy of Continuing Professional Education: the Khimki Regional Hospital and the Z.A. Bashlyaeva Children's City Clinical Hospital. The study included 120 children aged from 3 months to 3 years, divided into 4 groups. Group 1 and 2 were children with ARI, Group 3 and 4 were children with COVID-19. Body temperature in the 1st and 3rd groups was measured only by a halistane thermometer; in the 2nd and 4th groups - by a new generation intellectual thermograph with halistane thermometer control in the specified time intervals.Results. The study obtained high reliability of indicators of the new thermograph, designed to graphically display the dynamics of changes in body temperature during the day, compared with the halistane thermometer, commonly used in hospitals.Conclusions. The thermograph registers the child's body temperature with high reliability, which makes it possible to react to its changes in time. The use of thermograph makes it possible to set the critical value of body temperature at its rise for each user individually depending on his premorbid background, which is especially important in the group of children with a high risk of febrile convulsions and microcirculatory disorders in terms of prevention of the possible development of adverse events.