bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perilaku Hidup Bersih Dan Sehat (Phbs) Dari Kajian Pengetahuan Pencegahan Malaria Ibu Rumah Tangga
Authors: Bagau Ovita , Putri Ronasari Mahaji , Devi Hilda Mazarina 
Published: September 2022

Adanya fenomena masih rendahnya pengetahuan ibu rumah tangga tentang pencegahan malaria di Provinsi Papua. Penyakit malaria ini berbahaya dan mengancam kesehatan masyarakat. Kasus malaria yang semakin meningkat membutuhkan pemutusan rantai penularan. Rendahnya pengetahuan tentang pencegahan malaria diduga penyebabnya adalah kurangnya PHBS. Tujuan penelitian menghubungkan pengetahuan pencegahan malaria dengan PHBS ibu rumah tangga di wilayah kerja Puskesmas X Provinsi Papua. Cross sectional sebagai desain penelitian. Populasi sejumlah 45 orang dengan sampel 40 orang, menggunakan accidental sampling. Variabel independent pengetahuan ibu dan variabel dependent yakni PHBS. Instrumen adalah lembar kuesioner yang diadopsi dari peneliti lain. Uji fisher exact test digunakan untuk menganalisis data. Hasil menunjukkan pengetahuan ibu rumah tangga mayoritas kurang (52,5%), PHBS ibu rumah tangga sebagian besar kategori kurang (60,0%), ada hubungan pengetahuan tentang pencegahan malaria dengan PHBS pada kelompok ibu rumah tangga (p = 0,000). Diharapkan bagi peneliti selanjutnya agar meneliti peran budaya sebagai faktor determinan dari pengetahuan dan PHBS.
Penurunan Nyeri Osteoarthritis Dengan Teknik Relaksasi Genggam Jari
Authors: Vioneery Deoni , Listiyanawati Mutiara Dewi , Dirhan Dirhan 
Published: September 2022

Osteoarthritis merupakan penyakit sendi degeneratif, merupakan gangguan tersering terjadi pada lansia berusia di atas 65 tahun. Salah satu terapi nonfarmakologis yang dapat dilakukan untuk mengurangi nyeri osteoarhtritis adalah teknik relaksasi genggam jari. Nyeri yang dirasakan lansia biasanya sendi-sendi terasa sakit, kaku, dan bengkak. Khususnya sendi pada jari tangan, lutut, pinggul, dan tulang punggung. Penelitian ini bertujuan untuk meneliti penurunan nyeri osteoarthritis dengan teknik relaksasi genggam jari di Desa Wirun Kel. Plesungan Kec. Gondangrejo. Metode penelitian ini Pre Eksperimen, dengan model desain satu kelompok pretest-postest,. Sampel diambil dengan teknik accidental sampling. Responden sebanyak 31 orang yang merupakan masyarakat Desa Wirun. Variabel bebas adalah teknik relaksasi genggam jari, dan variabel dependent adalah penurunan nyeri osteoarthritis. Pengumpulan data menggunakan lembar observasi, serta di analisis dengan univariat (penyajian distribusi frekuensi) dan bivariat (uji Wilcoxon). Hasil uji statistik didapatkan nilai pvalue 0,000 α 0,05 maka kesimpulan pada penelitian ini ada penurunan nyeri osteoarthritis dengan teknik relaksasi genggam jari.
THE EFFECT OF MULTIBALL TRAINING ON INCREASING BACKHAND BLOCKS IN THE SPARTA TABLE TENNIS GAME, MAKASSAR STATE UNIVERSITY
Authors: Defliyanto  , Panji Pangestu  
Published: September 2022

This study aims to determine the effect of multiball practice on improving backhand skills in table tennis and how multiball training affects backhand skills in table tennis. The research was conducted by random sampling to the population of all Spartan athletes, which amounted to 45 people . Data collection using test and measurement techniques. The test instrument used was In out shuffle-plyo push up to determine the effect of multiball training. The variables of this study included multiball as the independent variable, and improving backhand skills as the dependent variable. The data analysis technique used descriptive analysis techniques and inferential analysis through the SPSS.22 program with a significance level of 95% (? = 0.05).The results of the analysis showed that: (1) the in-out shuffle-plyo push up exercise was proven to increase backhand strokes with a contribution of 64.5%; (2) The in-out shuffle-plyopush up exercise group had a greater effect on increasing backhand strokes than the control group with an increase in out shuffle-plyo push ups of 12.85% from the pre - test average which was carried out before treatment with a posttest average , while for control only 3.9% of the average pretest and posttest scores .
BANGUNAN	GEDUNG RUMAH SAKIT	DI KABUPATEN CIANJUR DI LIHAT DARI	UNDANG-UNDANG NO 44 TAHUN 2009 TENTANG RUMAH SAKIT DAN	UNDANG-UNDANG NO 28 TAHUN 2002 TENTANG BANGUNANGEDUNG
Authors: Sihombing Alfies , Nuraeni Yeni , Triyunarti Wiwin 
Published: September 2022

ABSTRAK Rumah Sakit merupakan sarana publik dibidang kesehatan yang sangat dibutuhkan masyarakat. Sebagai sarana publik dibidang kesehatan, maka diperlukan sumber daya manusia, alat kesehatan bahkan sarana yang menunjang dalam pelayanan kesehatan tersebut. Sebagai sarana publik maka Rumah Sakit pun harus mempunyai gedung yang kemanfaatan disesuaikan dengan fungsinya. Bangunan gedung Rumah Sakit harus memenuhi persayaratan administratif dan persayaratan tehnis. Persyaratan administratif akan terbit ketika persyaratan tehnis dipenuhi. Salah satunya adalah sertifikat laik fungsi. Berdasarkan peraturan gedung bisa dimanfaatkan sesuai fungsi apabila SLF sudah terbit. SLF ini adalah keandalan bangunan gedung yang menjadi syarat secara tehnis. Kegagalan bangunan gedung disesuaikan dengan permasalahan yang ditemukan dilapangan, dengan begitu sanksi dapat diturunkan sesuai dengan permasalahan yang muncul. Kata kunci, Rumah Sakit, bangunan Gedung, Sertifikat Laik Fungsi ABSTRACT The hospital is a public facility in the health sector that is needed by the community. As a public facility in the health sector, human resources, medical equipment, and even facilities that support the health service are needed. As a public facility, the hospital must also have a building whose benefits are adjusted to its function. Hospital buildings must meet administrative and technical requirements. Administrative requirements will be issued when the technical requirements are met. One of them is a function-worthy certificate. Based on building regulations, it can be used according to its function when the SLF has been issued. This SLF is the reliability of the building which is a technical requirement. The failure of the building is adjusted to the problems found in the field, so sanctions can be lowered according to the problems that arise. Keywords, Hospital, Building, Function-worthy Certificate
Multiplanar knee kinematics-based test battery helpfully guide return-to-sports decision-making after anterior cruciate ligament reconstruction
Authors: Zhou Lan , Xu Yihong , Zhang Jing , Guo Luqi , Zhou Tianping , Wang Shaobai , Xu Weidong 
Published: September 2022

Background: There are currently no well-established criteria to guide return to sports (RTS) after anterior cruciate ligament reconstruction (ACLR). In this study, a new test battery consisting of subjective and objective tests, especially multiplanar knee kinematics assessment, was developed to aid RTS decision making after ACLR.Methods: This study was conducted with 30 patients who were assessed a mean of 9.2 ± 0.5 months after ACLR. All patients underwent complete evaluations of both lower limbs with four objective assessments [isokinetic, hop, knee laxity, and 6–degree of freedom (6DOF, angle: flexion-extension, varus-valgus, internal-external rotation; translation: anteroposterior, proximodistal, mediolateral) knee kinematics tests] and two subjective assessments [International Knee Documentation Committee (IKDC) and Anterior Cruciate Ligament Return to Sport after Injury (ACL-RSI) questionnaires]. Limb symmetry indices (LSIs) of knee strength, hop distance, and range of motion (ROM) of knee kinematics were calculated. LSI ≥90%, IKDC scale score within the 15th percentile for healthy adults, and ACL-RSI score &gt;56 were defined as RTS criteria.Results: Significant differences between affected and contralateral knees were observed in the quadriceps strength (p &lt; 0.001), hamstring strength (p = 0.001), single hop distance (p &lt; 0.001), triple hop distance (p &lt; 0.001), and rotational ROM (p = 0.01). Only four patients fulfilled the overall RTS criteria. The percentages of patients fulfilling individual criteria were: quadriceps strength, 40%; hamstring strength, 40%; single hop distance, 30%; triple hop distance, 36.7%; knee ligament laxity, 80%; flexion-extension, 23.3%; varus-valgus rotation, 20%; internal-external rotation, 66.7%; anteroposterior translation, 20%; proximodistal translation, 33.3%; mediolateral translation, 26.7%; IKDC scale score, 53.3%; and ACL-RSI score, 33.3%.Conclusion: At an average of 9 months after ACLR, objectively and subjectively measured knee functional performance was generally unsatisfactory especially the recovery of knee kinematics, which is an important prerequisite for RTS.
Precision control of polyurethane filament drafting and winding based on machine vision
Authors: Wu Shilin , Yang Huayu , Liu Xiangyan , Jia Rui 
Published: September 2022

In the biomedical field, polyurethane (PU) is widely used in interventional catheters, artificial hearts, artificial blood vessels, orthopedic materials, medical adhesives, and other medical devices. In this paper, a method based on machine vision was proposed to control the drafting and winding accuracy of PU filament in order to solve the problem of centrifugal runout when the mold rotates. The centrifugal runout of the mold directly affected the preparation efficiency and quality of long artificial blood vessel by wet spinning. Through non-contact real-time detection of the filament diameter and the angle between the axis of filament and the axis of mold, the motion parameters of the two motors driving the moving platform and the drafting roller could be adjusted in real time to achieve the purpose of online real-time control of filament drafting and winding accuracy. The vision control method proposed in this paper was used to carry out the PU tube preparation experiment. The visual measurement results of the filament diameter and the included angle were compared with the manual measurement results. The average value of the diameter error is 0.0096mm, and the average value of winding angle is 0.4777°. The results proved the accuracy of the visual measuring method and testified it feasible to using machine vision instead of manual method to detect filament diameter and winding angle. Properties of the prepared PU tube were tested and analyzed. The filament diameter measured by the 3D microscope was about 0.87 mm and significantly smaller than the filament diameter before winding. This indicated that the winding was uniform, the extrusion was tight, and the adhesion was good.
SARS-CoV-2 induced hepatic injuries and liver complications
Authors: Saeed Umar , Piracha Zahra Zahid , Uppal Sara Rizwan , Waheed Yasir , Uppal Rizwan 
Published: September 2022

BackgroundCoronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is resilient, highly pathogenic, and rapidly transmissible. COVID-19 patients have been reported to have underlying chronic liver abnormalities linked to hepatic dysfunction.DiscussionViral RNAs are detectable in fecal samples by RT-PCR even after negative respiratory samples, which suggests that SARS-CoV-2 can affect the gastrointestinal tract and the liver. The case fatality rates are higher among the elderly and those with underlying comorbidities such as hypertension, diabetes, liver abnormality, and heart disease. There is insufficient research on signaling pathways. Identification of molecular mechanisms involved in SARS-CoV-2-induced damages to hepatocytes is challenging. Herein, we demonstrated the multifactorial effects of SARS-CoV-2 on liver injury such as psychological stress, immunopathogenesis, systemic inflammation, ischemia and hypoxia, drug toxicity, antibody-dependent enhancement (ADE) of infection, and several others which can significantly damage the liver.ConclusionDuring the COVID-19 pandemic, it is necessary for clinicians across the globe to pay attention to SARS-CoV-2-mediated liver injury to manage the rising burden of hepatocellular carcinoma. To face the challenges during the resumption of clinical services for patients with pre-existing liver abnormalities and HCC, the impact of SARS-CoV-2 on hepatocytes should be investigated both in vitro and in vivo.
In vitro investigation on lactic acid bacteria isolatedfrom Yak faeces for potential probiotics
Authors: Zhang Qingli , Wang Meng , Ma Xin , Li Zhijie , Jiang Chenghui , Pan Yangyang , Zeng Qiaoying 
Published: September 2022

In order to evaluate the potential and safety of lactic acid bacteria (LAB) isolated from faeces samples of Ganan yak as probiotic for prevention and/or treatment of yak diarrhea, four strains of LAB including Latilactobacillus curvatus (FY1), Weissella cibaria (FY2), Limosilactobacillus mucosae (FY3), and Lactiplantibacillus pentosus (FY4) were isolated and identified in this study. Cell surface characteristics (hydrophobicity and cell aggregation), acid resistance and bile tolerance, compatibility, antibacterial activity and in vitro cell adhesion tests were also carried out to evaluate the probiotic potential of LAB. The results showed that the four isolates had certain acid tolerance, bile salt tolerance, hydrophobicity and cell aggregation, all of which contribute to the survival and colonization of LAB in the gastrointestinal tract. There is no compatibility between the four strains, so they can be combined into a mixed probiotic formula. Antimicrobial tests showed that the four strains were antagonistic to Escherichia coli, Staphylococcus aureus, and Salmonella typhimurium. Moreover, the in vitro safety of the four isolates were determined through hemolytic analysis, gelatinase activity, and antibacterial susceptibility experiments. The results suggest that all the four strains were considered as safe because they had no hemolytic activity, no gelatinase activity and were sensitive to most antibacterial agents. Moreover, the acute oral toxicity test of LAB had no adverse effect on body weight gain, food utilization and organ indices in Kunming mice. In conclusion, the four LAB isolated from yak feces have considerable potential to prevent and/or treat yak bacterial disease-related diarrhea.
New regulation on medical devices made of substances: Opportunities and challenges for pharmacological and toxicological research
Authors: Fimognari Carmela , Barrajón-Catalán Enrique , Luceri Cristina , Turrini Eleonora , Raschi Emanuel , Bigagli Elisabetta 
Published: September 2022

The Medical Device (MD) Regulation EU 2017/745 (MDR) has provided a completely new and more robust regulatory framework at guarantee of the safety and efficacy of therapeutic options accessing the market. At the same time, the MDR poses several challenges for stakeholders, among which, the most significant lying on MDs made of substances (MDMS) whose mechanism of action should be non-pharmacological, immunological, or metabolic.Moving from single active substances to very complex mixtures, such as the case of natural products, the demonstration of the non-targeted, non-pharmacological mechanism, is even much more challenging since it is very hard to specifically identify and characterize all the interactions each constituent can have within the body.New scientific paradigms to investigate these multiple interactions and delineate the principal mechanism of action through which the effect is achieved are necessary for the correct regulatory classification and placement in the market of MDMS.This article will discuss the difficulties in delineating the boundaries between pharmacological and non-pharmacological mechanisms, practical approaches to the study of complex mixtures and the challenges on the application of current experimental paradigms to the study of the mechanism of action of MDMS.
Tracking the impacts of precipitation phase changes through the hydrologic cycle in snowy regions: From precipitation to reservoir storage
Authors: Wrzesien Melissa L. , Pavelsky Tamlin M. , Sobolowski Stefan P. , Huning Laurie S. , Cohen Jonathan S. , Herman Jonathan D. 
Published: September 2022

Cool season precipitation plays a critical role in regional water resource management in the western United States. Throughout the twenty-first century, regional precipitation will be impacted by rising temperatures and changing circulation patterns. Changes to precipitation magnitude remain challenging to project; however, precipitation phase is largely dependent on temperature, and temperature predictions from global climate models are generally in agreement. To understand the implications of this dependence, we investigate projected patterns in changing precipitation phase for mountain areas of the western United States over the twenty-first century and how shifts from snow to rain may impact runoff. We downscale two bias-corrected global climate models for historical and end-century decades with the Weather Research and Forecasting (WRF) regional climate model to estimate precipitation phase and spatial patterns at high spatial resolution (9 km). For future decades, we use the RCP 8.5 scenario, which may be considered a very high baseline emissions scenario to quantify snow season differences over major mountain chains in the western U.S. Under this scenario, the average annual snowfall fraction over the Sierra Nevada decreases by &gt;45% by the end of the century. In contrast, for the colder Rocky Mountains, the snowfall fraction decreases by 29%. Streamflow peaks in basins draining the Sierra Nevada are projected to arrive nearly a month earlier by the end of the century. By coupling WRF with a water resources model, we estimate that California reservoirs will shift towards earlier maximum storage by 1–2 months, suggesting that water management strategies will need to adapt to changes in streamflow magnitude and timing.
Associations of lipid parameters with non-alcoholic fatty liver disease in type 2 diabetic patients according to obesity status and metabolic goal achievement
Authors: Zhu Zengzhe , Yang Ningning , Fu Hongmei , Yuan Gang , Chen Yong , Du Tingting , Zhou Xinrong 
Published: September 2022

AimsNon-obese non-alcoholic fatty liver disease (NAFLD) phenotype has sparked interest and frequently occurred in type 2 diabetes mellitus (T2DM). Information on associations between lipid parameters and NAFLD in non-obese patients with diabetes has been lacking. We aimed to investigate the relationships between lipid parameters and NAFLD according to obesity status and metabolic goal achievement in T2DM patients.MethodsA total of 1,913 T2DM patients who were hospitalized between June 2018 and May 2021 were cross-sectionally assessed. We used logistic regression models to estimate the associations of lipid parameters with NAFLD risk according to obesity and metabolic goal achievement status.ResultsHigher triglycerides, non-HDL-cholesterol, and all lipid ratios including (total cholesterol/HDL-cholesterol, triglyceride/HDL-cholesterol, LDL-cholesterol/HDL-cholesterol, non-HDL-cholesterol/HDL-cholesterol), and lower HDL-cholesterol were associated with NAFLD risk in both non-obese and obese patients. The associations were stronger in non-obese patients than in obese patients. Further, the inverse associations of total cholesterol and LDL-cholesterol with NAFLD risk were only detected in non-obese patients. Triglycerides, HDL-cholesterol, and all lipid ratios studied were significantly associated with NAFLD risk, irrespective of whether the patients achieved their HbA1c, blood pressure, and LDL-cholesterol goal. The presence of poor lipids and lipid ratios were more strongly associated with NAFLD in patients who attained the HbA1c, blood pressure, and/or LDL-cholesterol goal than in those who did not achieve the goal attainment.ConclusionsThe associations of lipids and lipid ratios with NAFLD risk were stronger in T2DM patients who were non-obese and achieved the HbA1c, blood pressure, and/or LDL-cholesterol goal attainment.
Elevated pulse pressure correlated with reduced retinal peripapillary capillary in thyroid-associated ophthalmology with visual field defect
Authors: Ye Jie , Liu Weijie , Hu Xiaozhou , Jiang Hongxiao , Xu Mingna , Jin Haochen , Wang Mengting , Liu Zihui , Chen Qi , Wu Wencan , Tu Yunhai 
Published: September 2022

PurposeTo quantify the retinal vessel density in thyroid-associated ophthalmology (TAO) patients with visual field (VF) defect and examine its associations with mechanical and system vascular risk factors for underlying pathogenesis of VF defect in TAO.MethodsThe cohort was composed of 62 TAO eyes (39 with VF defect and 23 without VF defect). The pulse pressure (PP), intraocular pressure (IOP), ophthalmic rectus muscular index (MI), superficial retinal capillary plexus (SRCP), radial peripapillary capillary (RPC) density, and other related parameters were measured. The associations among these factors and VF mean deviation (MD) were analyzed.ResultsIn TAO patients with VF defect, reduced RPC density, higher PP, and larger horizontal and vertical MI were found (all P &lt; 0.03) when compared to TAO patients without VF defect. The RPC density was correlated with VF MD value (r = 0.242, P = 0.029), while SRCP density was not (P = 0.419). In univariable general estimating equation (GEE) analysis with RPC density as the outcome, PP and its fluctuation showed a significant association (both P &lt; 0.04). In the final RPC model with multivariable GEE analysis, only PP (β = -0.082, P = 0.029) showed significance while PP fluctuation (P = 0.080) did not.ConclusionsThe elevated PP was correlated with reduced retinal peripapillary perfusion in TAO resulting in VF defect. These data suggested that the system vascular factor may be important in the pathogenesis of reduced retinal perfusion resulting in visual impairment in TAO.
Deep-learning-based surrogate model for fast and accurate simulation in pipeline transport
Authors: Qin Feng , Yan Zhenghe , Yang Peng , Tang Shenglai , Huang Hu 
Published: September 2022

A new deep-learning-based surrogate model is developed and applied for predicting dynamic temperature, pressure, gas rate, oil rate, and water rate with different boundary conditions in pipeline flow. The surrogate model is based on the multilayer perceptron (MLP), batch normalization and Parametric Rectified Linear Unit techniques. In training, the loss function for data mismatch is considered to optimize the model parameters with means absolute error (MAE). In addition, we also use the dynamic weights, calculated by the input data value, to increase the contribution of smaller inputs and avoid errors caused by large values eating small values in total loss. Finally, the surrogate model is applied to simulate a complex pipeline flow in the eastern part of the South China Sea. We use flow and pressure boundary as the input data in the numerical experiment. A total of 215690 high-fidelity training simulations are performed in the offline stage with commercial software LeadFlow, in which 172552 simulation runs are used for training the surrogate model, which takes about 240 min on an RTX2060 graphics processing unit. Then the trained model is used to provide pipeline flow forecasts under various boundary conduction. As a result, it is consistent with those obtained from the high-fidelity simulations (e.g., the media of relative error for temperature is 0.56%, pressure is 0.79%, the gas rate is 1.02%, and oil rate is 1.85%, and water is 0.80%, respectively). The online computations from our surrogate model, about 0.008 s per run, achieve speedups of over 1,250 relative to the high-fidelity simulations, about 10 s per run. Overall, this model provides reliable and fast predictions of the dynamic flow along the pipeline.