bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable Bioconversion of Glycerine Pitch into the Novel Wickerhamomyces anomalus Bio-preservative
Authors: Syauqi Taufiq Ahmad , Jeremy Wong Hau Seung , Ab Satar Nur Syuhada Izwani , Yusri Amirah , Azami Nor Azura , Akmar Nurul Julia , Abdullah Amirul Al-Ashraf 
Published: December 2022

Background:
Yeasts with high protein content are used as single-cell proteins due to their nutritional values and rare pathogenicity. However, the nucleic acid of the yeasts must be removed before consumption to avoid hazards to health. Wickerhamomyces anomalus is an authorized bio-preservative with promising antifungal activity and safety. However, its high protein content associ-ated with high nucleic acid content results in high nitrogen content that imposes additional down-stream processing costs due to the nucleic acid removal step required to prevent uric acid precipitation which leads to various health concerns.

Objectives:
The objectives were to (i) isolate a novel Wickerhamomyces anomalus strain with low nitrogen content and (ii) to optimize the production of W. anomalus biomass through response surface methodology (RSM).

Methods:
The novel Wickerhamomyces sp. USMAST-TP1 with low nitrogen content was isolated from fermented food and its biomass was optimized through RSM.

Results:
Wickerhamomyces sp. USMAST-TP1 showed promising tolerance to glycerine pitch with a higher composition of growth-inhibiting impurities where its biomass was not negatively affected by excessive glycerine pitch supply. Upon optimization through RSM, 11.4 g/L biomass harboring pro-tein content of 13% was achieved.

Conclusion:
The >17-fold lower nitrogen content of 2% indicated low nucleic acid content compared to common W. anomalus strains, thus the costly nucleic acid purification steps can be excluded, easing applications in agro-food industries.
Developing a Technical-Oriented Taxonomy to Define Archetypes of Conversational Agents in Health Care: Literature Review and Cluster Analysis
Authors: Denecke Kerstin , May Richard 
Published: December 2022

Background
The evolution of artificial intelligence and natural language processing generates new opportunities for conversational agents (CAs) that communicate and interact with individuals. In the health domain, CAs became popular as they allow for simulating the real-life experience in a health care setting, which is the conversation with a physician. However, it is still unclear which technical archetypes of health CAs can be distinguished. Such technical archetypes are required, among other things, for harmonizing evaluation metrics or describing the landscape of health CAs.

Objective
The objective of this work was to develop a technical-oriented taxonomy for health CAs and characterize archetypes of health CAs based on their technical characteristics.

Methods
We developed a taxonomy of technical characteristics for health CAs based on scientific literature and empirical data and by applying a taxonomy development framework. To demonstrate the applicability of the taxonomy, we analyzed the landscape of health CAs of the last years based on a literature review. To form technical design archetypes of health CAs, we applied a k-means clustering method.

Results
Our taxonomy comprises 18 unique dimensions corresponding to 4 perspectives of technical characteristics (setting, data processing, interaction, and agent appearance). Each dimension consists of 2 to 5 characteristics. The taxonomy was validated based on 173 unique health CAs that were identified out of 1671 initially retrieved publications. The 173 CAs were clustered into 4 distinctive archetypes: a text-based ad hoc supporter; a multilingual, hybrid ad hoc supporter; a hybrid, single-language temporary advisor; and, finally, an embodied temporary advisor, rule based with hybrid input and output options.

Conclusions
From the cluster analysis, we learned that the time dimension is important from a technical perspective to distinguish health CA archetypes. Moreover, we were able to identify additional distinctive, dominant characteristics that are relevant when evaluating health-related CAs (eg, input and output options or the complexity of the CA personality). Our archetypes reflect the current landscape of health CAs, which is characterized by rule based, simple systems in terms of CA personality and interaction. With an increase in research interest in this field, we expect that more complex systems will arise. The archetype-building process should be repeated after some time to check whether new design archetypes emerge.
TINJAUAN USIA PERKAWINAN MENURUT HUKUM ISLAM (STUDI UU NO. 16 TAHUN 2019 PERUBAHAN ATAS UU NO. 1 TAHUN 1974 TENTANG PERKAWINAN)
Authors: Harlina Yuni 
Published: December 2022

Abstrak: Salah satu faktor terpenting dalam persiapan perkawinan adalah faktor usia. Sebab dalam perkawinan dituntut adanya kedewasaan dan kematangan dari masing-masing calon yang akan melangsungkan perkawinan sebagai modal yang sangat besar dan berarti dalam upaya meraih kebahagiaan dalam rumah tangga. Dalam perspektif hukum Islam, batas usia seseorang untuk melangsungkan perkawinan tidak disebutkan secara eksplisit, tetapi mengacu kepada makna “balaghu al-nikah”, sebagaimana disebutkan dalam firman Allah Swt pada Qs. Al-Nisa ayat 6 yaitu, seseorang dianggap dewasa (akil baligh) apabila pernah bermimpi yang menyebabkan keluar mani (ihtilam) bagi pria, dan mengalami menstruasi (haids) bagi wanita. Namun demikian, usia kedewasaan bagi masing-masing pria dan wanita tidaklah sama, tergantung pada keadaan kesehatan fisik seseorang, pengaruh biologis, iklim lingkungan social, ekonomi, pendidikan, emosi dan tanggung jawab serta keyakinan agama bagi pasangan yang akan melangsungkan perkawinan. Seiring dengan perkembangan zaman, maka ketentuan usia perkawinan di Indonesia yang ada dalam Undang-undang Nomor 1 Tahu 1974 perlu diubah dan disesuaikan lagi. Maka dipandang sangat perlu untuk melakukan upaya-upaya pembaharuan usia perkawinan di Indonesia disesuaikan dengan situasi dan kondisi di era milenial saat ini bahwa dalam pasal 7 ayat (1) UU Perkawinan No. 16 Tahun 2019 perkawinan hanya di izinkan apabila pria dan wanita sudah mencapai umur 19 (sembilhan belas) tahun. Hal ini dengan maksud membangun kualitas generasi Indonesia menuju masa depan yang lebih unggul.Kata kunci: Usia Perkawinan, Islam dan Undang-undang Perkawinan
The procedure for adopting an administrative act as a condition for its legality
Authors: Turchak S.M. , Lyutikov P.S. 
Published: December 2022

Modern trends in the field of domestic public administration, constant updating of the legal framework and its modernization give impetus to the scientific development of the relevant issues. Interestingly, this process is inverse and interrelated. The close connection between theory and practice, law-making and science is an important condition for the effectiveness of any system, including any social one, since the mandatory adherence to the principle of scientificity has always served the stability and effectiveness of the functioning of the public administration system and the state in general, always provided a basis for taking into account historical experience, systematically ensured the productivity and correctness of the analysis of the current state of affairs with the identification of problems and the development of ways to solve them, as well as promptly provided empirical material for forecasting future events.
The article examines, based on the analysis of doctrinal and normative sources, the procedure for adopting an administrative act as a condition for its legality.
It is noted that the procedure for the adoption of an administrative act should be understood as the procedure established by law for the adoption (adoption, rendering) of a decision or a legally significant targeted action of an individual nature that has an external impact with the aim of achieving certain legal results for specific subjects – establishing, changing or terminating them rights and obligations.
On the basis of a generalized analysis of known approaches to distinguishing the stages of adoption (adoption, issuance) of an administrative act, as well as the corresponding provisions of the Law of Ukraine «On Administrative Procedure», a unified model of such a procedure is outlined, which, according to the author, consists of the following stages: 1) initiation of administrative proceedings and initiation of an administrative case; 2) preparation of an administrative case for resolution; 3) investigation of the circumstances of the case and collection of evidence; 4) consideration of an administrative case; 5) adoption of an administrative act; 6) appeal of an administrative act (optional).
Evaluation of a real-time PCR in combination with a cultivation method for the detection of Brucella abortus in organs of infected cattle in southern Italy
Authors: Manzulli Viviana , Rondinone Valeria , Serrecchia Luigina , Petrella Antonio , Scaltrito Domenico , Marino Leonardo , Pace Lorenzo , Luigia Prencipe Maria , Cipolletta Dora , Nitti Mauro , Fasanella Antonio , Poppa Elena , Galante Domenico 
Published: December 2022

Abstract

Introduction
Brucellosis is a widespread zoonosis of great economic importance for livestock farming in many areas of the world. It is a highly infectious disease which is diagnosed using conventional serological and microbiological methods. The aim of this study was to assess the efficiency of a specific real-time PCR in combination with broth cultivation in detecting Brucella spp. in organs of infected cattle, in order to compare the sensitivity of the two approaches and the time needed in them until a correct diagnosis is made.

Material and Methods
We examined 67 organs collected from 10 cattle slaughtered following a brucellosis outbreak which occurred in February 2016 in southern Italy. The research was carried out by enrichment broth cultivations in combination with a real-time PCR every week for six weeks.

Results

Brucella strains were isolated by cultivation from 44 enrichment broths of organs. All isolates were later identified as Brucella abortus by real-time PCR. Using this method in combination with cultivation made it possible to identify the same percentage of infected animals faster than by cultivation alone. Moreover, the same diagnostic results were obtained, on average two weeks before they would have been using only cultivation. In almost all cases, Brucella was detected by real-time PCR after the first week of cultivation in pre-enrichment Brucella broth, while the bacterial growth was evident usually after 2 or 3 weeks.

Conclusion
Real-time PCR has allowed results to be obtained faster than in the classical microbiological method, reducing the response times to identify positive animals by half.
Screening for Coxiella burnetii in dairy cattle herds in Poland
Authors: Szymańska-Czerwińska Monika , Jodełko Agnieszka , Osiński Zbigniew , Niemczuk Krzysztof 
Published: December 2022

Abstract

Introduction
The intracellular bacterium Coxiella burnetii is the aetiological agent of Q fever, a zoonosis affecting many animal species worldwide. Cattle and small ruminants are considered the major reservoirs of the bacteria and they shed it through multiple routes.

Material and Methods
A total of 2,180 sera samples from 801 cattle herds in all Polish voivodeships were tested by ELISA for the presence of specific antibodies. Milk samples were obtained from seropositive cows in 133 herds as part of a separate study. The milk samples were examined by ELISA and real-time PCR tests.

Results
Seroprevalence at the animal level was 7.06% and true positive seroprevalence was 6.0% (95% confidence interval (CI) 1.1–9.4). Seroprevalence at the herd level was estimated at 11.1% and true positive seroprevalence was 10.5% (95% CI 3.2–15.8). Shedding of the pathogen in milk was detected by real-time PCR in 33 out of 133 tested herds (24.81%, 95% CI 17.74–33.04%) and the presence of C. burnetii antibodies was confirmed in 85 of them (63.9%, 95% CI 55.13–72.05%). The highest level of conformity between ELISA and real-time PCR results was obtained for bulk tank milk samples.

Conclusion

Coxiella burnetii infections are quite common in cattle herds across the country, which emphasises the crucial roles of surveillance and adequate biosecurity measures in the prevention and limitation of Q fever spread in Poland.
The Transition of Dramaturgy During Pandemic: From Staging to Streaming
Authors: Pramayoza Dede , Birowo Pandu 
Published: December 2022

This study discusses the transition of performances dramaturgy during the Covid-19 pandemic from analog to digital formats, from live performances commonly called staging to mediated performances which can be called performance streaming. The aim of study is to understand the application of ‘dramaturgical tactics’; and the reasons. Applying the dramaturgical analysis method investigation is directed at the transformation process from the basic concept of the performance to the practice of its presentation. The research departs from the premise that a dramaturgical process, namely the pre-production, production, and presentation of performance is permanently connected by a dramaturgical awareness. The analysis was carried out: (1) the idea of streaming; (2) performance technique; and (3) the form of performance streaming. Research shows that the critical changes in dramaturgy during the pandemic were triggered by the necessity to shift the mode of performance from staging to streaming, resulting in three dramaturgical awareness about transition, namely: (1) medium: from analog to digital performance; (2) creativity: from performer to content creator; and (3) the spectatorship: from spectator to voyeur. Perubahan Dramaturgi di Masa Pandemi: Dari Pementasan ke Siaran. Artikel ini membahas perihal transisi dramaturgi pertunjukan di masa pandemi Covid-19 dari format analog ke format digital, dari moda pertunjukan langsung yang lazim dinamakan pementasan ke pertunjukan termediasi yang dapat dinamakan siaran pertunjukan. Tujuannya untuk memahami bentuk penerapan ‘siasat dramaturgi’ serta alasan di baliknya. Mengunakan metode analisis dramaturgis, berupa investigasi atas proses transformasi dari konsep dasar pertunjukan menuju praktik presentasinya, penelitian berangkat dengan premis bahwa suatu proses dramaturgi, yakni tahap pra-produksi, produksi, dan presentasi pertunjukan selalu terhubung oleh satu kesadaran dramaturgis. Analisis dilakukan terhadap: (1) gagasan siaran pertunjukan; (2) teknik siaran pertunjukan; dan (3) bentuk siaran pertunjukan. Penelitian menunjukkan bahwa, perubahan penting dramaturgi di masa pandemi dipicu oleh suatu keharusan untuk memindahkan moda pertunjukan dari pementasan ke siaran, menghasilkan tiga kesadaran dramaturgis tentang peralihan, yakni: (1) medium: dari pementasan analog ke siaran digital; (2) kreativitas: dari penampil menjadi pembuat konten; dan (3) kepenontonan: dari spektator menjadi voyeur.
PENENTUAN NILAI KONDISI BANGUNAN GEDUNG BERDASARKAN METODE MATRIKS CONDITION SURVEY PROTOCOL 1 (CSP 1)
Authors: Wiyanto Henny , Yesaya Albert 
Published: December 2022

Building functions as a place for humans to carry out activities, such as living, doing business, religious activities, and other activities. Over time, there are many factors that may cause a degradation of quality or even damage a building. Therefore, to maintain the function and usability of the building, it is necessary to carry out inspections or assessments of the condition of the building which are managed properly and regularly. If there is no control, it will cause damage to the building and have an impact on large repair costs. This study aims to determine the value of the building overall condition. In the process, this research uses the Condition Survey Protocol 1 (CSP 1) matrix method based on visual inspection to assess one of the Mall in Jakarta. After analyzing the data, 1449 defects were found, which 1381 of them needed planned maintanance coded and 68 of them needed condition monitoring. It can be concluded that the results of the condition of the building as a whole get a total score of 2.35 which means the building is in the good rating category, which means that the structure is still strong and stable and only external damage/defects.

Abstrak
Bangunan berfungsi sebagai tempat manusia melakukan aktivitas, seperti bertempat tinggal, berbisnis, aktivitas keagamaan, dan aktivitas lainnya. Seiring berjalannya waktu, ada banyak faktor yang dapat menyebabkan penurunan kualitas atau bahkan merusak sebuah bangunan. Oleh karena itu, untuk menjaga fungsi dan kegunaan bangunan gedung, perlu dilakukan pemeriksaan atau penilaian terhadap kondisi bangunan gedung yang dikelola dengan baik dan teratur. Jika tidak ada pengendalian maka akan menyebabkan kerusakan pada bangunan dan berdampak pada biaya perbaikan yang besar. Penelitian ini bertujuan untuk menentukan nilai kondisi bangunan secara keseluruhan. Dalam prosesnya, penelitian ini menggunakan metode matriks Condition Survey Protocol 1 (CSP 1) berbasis inspeksi visual untuk menilai salah satu bangunan Mall di Jakarta. Setelah dilakukan analisis data, ditemukan 1449 kerusakan dimana 1381 kerusakan perlu dilakukan pemeliharaan terencana dan 68 kerusakan perlu dilakukan pemantauan kondisi. Dapat disimpulkan bahwa hasil kondisi bangunan gedung secara keseluruhan mendapatkan skor total sebesar 2,35 yang berarti bangunan gedung masuk kategori peringkat baik yang artinya struktural masih kuat dan stabil serta kerusakan/cacat hanya bagian luar.
PERINGKAT FAKTOR-FAKTOR YANG MEMPENGARUHI TERJADINYA COST OVERRUN PADA PROYEK KONSTRUKSI PADA MASA PANDEMI COVID-19
Authors: Andian Vincent , Waty Mega 
Published: December 2022

A construction project is the process of specification and design of all resources on a project, such as funds, materials, equipment, technology, manpower, and time to complete construction in accordance with applicable requirements. Construction projects experience several obstacles that hinder the process of success of a project, one of which is cost overruns. Cost overruns are an important issue in the success of a construction, coupled with the Covid-19 pandemic, the possibility of cost overruns is even greater. This research was conducted by collecting data through a literature study, then a survey was carried out using a questionnaire with a likert scale of 1-5. The data will be provided to construction service providers to measure the degree of influence of factors that affect the occurrence of cost overruns on construction projects during the Covid-19 pandemic and find their ratings using the Relative Importance Index (RII) Method. Of the 20 factors obtained, after passing the validity and reliability test, 17 factors were obtained. Furthermore, it is looked for rankings of 17 factors that influence the occurrence of cost overruns with the RII method. From these results will be obtained the highest ranks and the lowest most influential.

Abstrak
Proyek konstruksi adalah proses spesifikasi dan desain dari segala sumber daya pada proyek, seperti dana, material, peralatan, teknologi, tenaga kerja, dan waktu untuk menyelesaikan suatu pembangunan sesuai dengan persyaratan yang berlaku. Proyek konstruksi mengalami beberapa kendala yang menghambat proses keberhasilan suatu proyek, salah satunya adalah pembengkakan biaya. Pembengkakan biaya menjadi masalah yang penting dalam keberhasilan suatu konstruksi, ditambahnya dengan pandemi Covid-19, kemungkinan terjadinya pembengkakan biaya semakin besar. Penelitian ini dilakukan dengan mengumpulkan data melalui studi literatur, kemudian dilakukan survei memakai kuesioner dengan skala likert 1-5. Data tersebut akan diberikan kepada penyedia jasa konstruksi untuk mengukur tingkat pengaruh faktor yang mempengaruhi terjadinya pembengkakan biaya pada proyek konstruksi pada saat pandemi Covid-19 dan mencari peringkatnya menggunakan metode Relative Importance Index (RII). Dari 20 faktor yang didapat, setelah melewati uji validitas dan reliabilitas diperoleh 17 faktor. Selanjutnya di cari peringkat dari 17 faktor yang mempengaruhi terjadinya pembengkakan biaya dengan metode. Dari hasil tersebut akan diperoleh peringkat tertinggi dan terendah yang paling berpengaruh.
EVALUATION OF DRAINAGE CHANNEL CAPACITY ON JALAN BUDI KARYA, PONTIANAK SELATAN SUB-DISTRICT
Authors: Suci Suci , Herawati Henny , Umar Umar , Soeryamassoeka SB , Gunarto Danang 
Published: December 2022

Drainage is one of the most critical components to be maintained and developed in a strategically healthy and comfortable urban environment. There are often puddles of water on Budi Karya Street, especially at the Permai Reservoir Complex. In solving the existing inundation problem, primary and secondary data are needed. Primary data is in the form of longitudinal and transverse sections of the channel, while secondary data is in the form of location maps, tidal data, and rainfall data used to analyze hydrology. Based on the analysis of the capacity of Budi Karya's drainage channel using HEC -RAS software as a drainage channel flow modeling tool to view the water level profile along the channel, channel perspective drawing, or hydrograph, it was found that the Budi Karya drainage channel could not accommodate the planned discharge for return periods 2 and 5 Year. Therefore, it is necessary to improve drainage in the form of the normalization of drainage channels.
Is arthroplasty necessary for three and four-part proximal humerus fractures in elderly?
Authors: Demirtas Yunus , Kaya Ozgur , Emet Abdulsamet 
Published: December 2022

Background/Aim: Proximal humerus fractures are common in elderly patients. Treatment of three and four-part fractures is especially controversial in these patients. In recent years, surgical options have been widely used, especially among shoulder surgeons. The purpose of this study was to compare clinical results of conservative and arthroplasty methods.
Methods: Between 2016 and 2020, 30 patients who were treated for Neer type 3 and type 4 proximal humeral fractures were included in the study. Patient data were evaluated retrospectively and then divided into three groups. Group 1 was treated conservatively, group 2 underwent hemiarthroplasty; and group 3 underwent reverse total shoulder arthroplasty. CONSTANT and visual analog scale (VAS) scores and radiological results at six months were evaluated retrospectively from patient records. At the last control they have been evaluated with CONSTANT, University of California/Los Angeles. (UCLA), and VAS scores.
Results: Twenty-three (76.7%) of the patients included in the study were females. The mean age was 73.5 (5.7) years. The mean follow-up period was 33 (2.5) months. The mean follow-up periods in groups 1–3 were 33.3 (2.9), 32.8 (2), and 32.2 (2.9) months, respectively. When the CONSTANT scores of the patients were compared at the sixth month, they were observed to be better in the reverse total shoulder arthroplasty group (P = 0.001). Final control CONSTANT scores in the hemiarthroplasty group were lower than in the other groups (P = 0.001) and similar in the reverse shoulder prosthesis and conservative treatment group (P = 1). When the UCLA scores of all groups were compared, the mean UCLA scores were found to be significantly higher in groups 1 and 3 compared to group 2 (P = 0.001). When the VAS scores of the patients were compared, a significant difference between all groups was detected (P < 0.05). The highest VAS scores were observed in group 2, the second highest in group 1, and the lowest in group 3.
Conclusion: For treatment of proximal humerus fractures in the elderly, patients should be evaluated according to activity levels and expectations, and surgical treatment should be suggested rather than ordered.