bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ALMA REBELS Survey: specific star formation rates in the reionization era
Authors: Topping Michael W , Stark Daniel P , Endsley Ryan , Bouwens Rychard J , Schouws Sander , Smit Renske , Stefanon Mauro , Inami Hanae , Bowler Rebecca A A , Oesch Pascal , Gonzalez Valentino , Dayal Pratika , da Cunha Elisabete , Algera Hiddo , van der Werf Paul , Pallottini Andrea , Barrufet Laia , Schneider Raffaella , De Looze Ilse , Sommovigo Laura , Whitler Lily , Graziani Luca , Fudamoto Yoshinobu , Ferrara Andrea 
Published: August 2022

ABSTRACT
We present specific star formation rates (sSFRs) for 40 ultraviolet (UV)-bright galaxies at z ∼ 7–8 observed as part of the Reionization Era Bright Emission Line Survey (REBELS) Atacama Large Millimeter/submillimeter Array (ALMA) large programme. The sSFRs are derived using improved star formation rate (SFR) calibrations and spectral energy distribution (SED)-based stellar masses, made possible by measurements of far-infrared (FIR) continuum emission and [C ii]-based spectroscopic redshifts. The median sSFR of the sample is $18_{-5}^{+7}$ Gyr−1, significantly larger than literature measurements lacking constraints in the FIR, reflecting the larger obscured SFRs derived from the dust continuum relative to that implied by the UV+optical SED. We suggest that such differences may reflect spatial variations in dust across these luminous galaxies, with the component dominating the FIR distinct from that dominating the UV. We demonstrate that the inferred stellar masses (and hence sSFRs) are strongly dependent on the assumed star formation history in reionization-era galaxies. When large sSFR galaxies (a population that is common at z &gt; 6) are modelled with non-parametric star formation histories, the derived stellar masses can increase by an order of magnitude relative to constant star formation models, owing to the presence of a significant old stellar population that is outshined by the recent burst. The [C ii] line widths in the largest sSFR systems are often very broad, suggesting dynamical masses capable of accommodating an old stellar population suggested by non-parametric models. Regardless of these systematic uncertainties among derived parameters, we find that sSFRs increase rapidly toward higher redshifts for massive galaxies (9.6 &lt; log (M*/M⊙) &lt; 9.8), evolving as (1 + z)1.7 ± 0.3, broadly consistent with expectations from the evolving baryon accretion rates.
Deprojection of X-ray data in galaxy clusters: confronting simulations with observations
Authors: Sarkar Kartick C , Dey Arjun , Sharma Prateek 
Published: August 2022

ABSTRACT
Numerical simulations with varying realism indicate an emergent principle−multiphase condensation and large cavity power occur when the ratio of the cooling time to the free-fall time (tcool/tff) falls below a threshold value close to 10. Observations indeed show cool-core signatures when this ratio falls below 20–30, but the prevalence of cores with tcool/tff ratio below 10 is rare as compared to simulations. In X-ray observations, we obtain projected spectra from which we have to infer radial gas density and temperature profiles. Using idealized models of X-ray cavities and multiphase gas in the core and 3D hydro jet-ICM simulations, we quantify the biases introduced by deprojection based on the assumption of spherical symmetry in determining tcool/tff. We show that while the used methods are able to recover the tcool/tff ratio for relaxed clusters, they have an uncertainty of a factor of 2−3 in systems containing large cavities (≳ 20 kpc). We also show that the mass estimates from these methods, in the absence of X-ray spectra close to the virial radius, suffer from a degeneracy between the virial mass (M200) and the concentration parameter (c) in the form of M200c2 ≈ constant. Additionally, the lack of soft-X-ray (≲ 0.5 keV) coverage and poor spatial resolution makes us overestimate min(tcool/tff) by a factor of few in clusters with min(tcool/tff) ≲ 5. This bias can largely explain the lack of cool-core clusters with min(tcool/tff) ≲ 5.
Fast nodal precession of the disc around Pleione requires a broken disc
Authors: Martin Rebecca G , Lepp Stephen 
Published: August 2022

ABSTRACT
Pleione is a Be star that is in a 218-d orbit with a low-mass binary companion. Recent numerical simulations have shown that a Be star disc can be subject to breaking when material is actively being fed into the inner parts of the disc. After breaking, the disc is composed of two rings: an inner ring that is anchored to the stellar equator and an outer ring that is free to nodally precess. A double ring disc may explain some of the observed variability in Pleione. We model the nodal precession of the outer disc ring that is driven by the companion on an observed time-scale of $80.5\, \rm yr$. We find that the outer ring of a broken disc in a binary with an eccentricity of eb = 0.6 can precess on the observed time-scale and have an outer radius that is in rough agreement with the observed disc size. An unbroken disc model cannot fit both the observed precession rate and disc size. Suppression of Kozai–Lidov driven disc eccentricity is more likely for a high binary eccentricity if the disc extends to the tidal truncation radius.
MAXI J1957+032: a new accreting millisecond X-ray pulsar in an ultra-compact binary
Authors: Sanna A , Bult P , Ng M , Ray P S , Jaisawal G K , Burderi L , Di Salvo T , Riggio A , Altamirano D , Strohmayer T E , Manca A , Gendreau K C , Chakrabarty D , Iwakiri W , Iaria R 
Published: August 2022

ABSTRACT
The detection of coherent X-ray pulsations at ∼314 Hz (3.2 ms) classifies MAXI J1957+032 as a fast-rotating, accreting neutron star. We present the temporal and spectral analysis performed using NICER observations collected during the latest outburst of the source. Doppler modulation of the X-ray pulsation revealed the ultra-compact nature of the binary system characterized by an orbital period of ∼1 h and a projected semimajor axis of 14 lt-ms. The neutron star binary mass function suggests a minimum donor mass of 1.7 × 10−2 M⊙, assuming a neutron star mass of 1.4 M⊙ and a binary inclination angle lower than 60 deg. This assumption is supported by the lack of eclipses or dips in the X-ray light curve of the source. We characterized the 0.5–10 keV energy spectrum of the source in outburst as the superposition of a relatively cold black-body-like thermal emission compatible with the emission from the neutron star surface and a Comptonization component with photon index consistent with a typical hard state. We did not find evidence for iron K α lines or reflection components.
Translational significance of CDKN2A/B homozygous deletion in isocitrate dehydrogenase-mutant astrocytoma
Authors: Fortin Ensign Shannon P , Jenkins Robert B , Giannini Caterina , Sarkaria Jann N , Galanis Evanthia , Kizilbash Sani H 
Published: August 2022

Abstract
Isocitrate dehydrogenase (IDH) 1 or 2 mutations confer a favorable prognosis compared to IDH-wildtype in astrocytoma, frequently denoting a lower grade malignancy. However, recent molecular profiling has identified specific aggressive tumor subgroups with clear clinical prognostic implications that are independent of histologic grading. The homozygous deletion of CDKN2A/B is the strongest implicated independent indicator of the poor prognosis within IDH-mutant astrocytoma, and the identification of this alteration in these lower histologic grade tumors transforms their biology toward an aggressive grade 4 phenotype clinically. CDKN2A/B homozygous deletion is now sufficient to define a grade 4 tumor in IDH-mutant astrocytomas regardless of histologic appearance, yet there are currently no effective molecularly informed targeted therapies for these tumors. The biological impact of CDKN2A/B homozygous deletion in IDH-mutant tumors and the optimal treatment strategy for this molecular subgroup remains insufficiently explored. Here we review the current understanding of the translational significance of homozygous deletion of CDKN2A/B gene expression in IDH-mutant astrocytoma and associated diagnostic and therapeutic implications.
Light control of droplets on photo-induced charged surfaces
Authors: Wang Fang , Liu Meijin , Liu Cong , Huang Chao , Zhang Lidong , Cui Anyang , Hu Zhigao , Du Xuemin 
Published: August 2022

ABSTRACT
The manipulation of droplets plays a vital role in fundamental research and practical applications, from chemical reactions to bioanalysis. As an intriguing and active format, light control of droplets, typically induced by photochemistry, photomechanics, light-induced Marangoni effects or light-induced electric fields, enables remote and contactless control with remarkable spatial and temporal accuracy. However, current light control of droplets suffers from poor performance and limited reliability. Here we develop a new superamphiphobic material that integrates the dual merits of light and electric field by rationally preparing liquid metal particles/poly(vinylidene fluoride-trifluoroethylene) polymer composites with photo-induced charge generation capability in real time, enabling light control of droplets on the basis of photo-induced dielectrophoretic force. We demonstrate that this photo-induced charged surface (PICS) imparts a new paradigm for controllable droplet motion, including high average velocity (∼35.9 mm s−1), unlimited distance, multimode motions (e.g. forward, backward and rotation) and single-to-multiple droplet manipulation, which are otherwise unachievable in conventional strategies. We further extend light control of droplets to robotic and bio-applications, including transporting a solid cargo in a closed tube, crossing a tiny tunnel, avoiding obstacles, sensing the changing environment via naked-eye color shift, preparing hydrogel beads, transporting living cells and reliable biosensing. Our PICS not only provides insight into the development of new smart interface materials and microfluidics, but also brings new possibilities for chemical and biomedical applications.
Nucleocapsid Antigenemia in Patients Receiving Anti-CD20 Therapy With Protracted COVID-19
Authors: Wilber Eli , Piantadosi Anne , Babiker Ahmed , McLendon Kaleb , O’Sick William , Fitts Eric , Webster Andrew S , Verkerke Hans , Kim James S , Phadke Varun K , Rouphael Nadine , Titanji Boghuma K , Blake William T , Howard-Anderson Jessica , Roback John D , Lam Wilbur A , Damhorst Gregory L 
Published: August 2022

Abstract
Immunocompromised patients with prolonged coronavirus disease 2019 symptoms present diagnostic and therapeutic challenges. We measured viral nucleocapsid antigenemia in 3 patients treated with anti-CD20 immunotherapy who acquired severe acute respiratory syndrome coronavirus 2 infection and experienced protracted symptoms. Our results support nucleocapsid antigenemia as a marker of persistent infection and therapeutic response.
It’s Not You, It’s SOSA: A Case Study on Breaking Up With an FDA-Cleared Susceptibility Testing System’s Oxacillin Results for Staphylococcus spp. Other Than S. aureus and S. lugdunensis
Authors: Yang Christine , Anahtar Melis N , Pierce Virginia M 
Published: August 2022

Abstract

Background
In 2021, the Clinical and Laboratory Standards Institute revised its susceptible oxacillin minimum inhibitory concentration (MIC) breakpoint for Staphylococcus spp. other than S. aureus and S. lugdunensis (SOSA) from  ≤0.25 to  ≤0.5 µg/mL. Here, we describe the response to this breakpoint change, which at the time of this study was not yet recognized by the US Food and Drug Administration (FDA), in our laboratory, where the primary method for antimicrobial susceptibility testing (AST) of SOSA is VITEK 2. VITEK 2 uses the Automated Expert System (AES) to integrate the results of oxacillin MIC and cefoxitin screen tests into a final interpretation; our laboratory also adjudicates discordant oxacillin and cefoxitin results using a PBP2a test.

Methods
We retrospectively reviewed and assessed the yield of PBP2a testing for 189 SOSA isolates with discordant (when applying the FDA susceptible oxacillin breakpoint of ≤0.25 µg/mL) VITEK 2 oxacillin and cefoxitin results, and then prospectively incorporated PBP2a testing for isolates with oxacillin MICs of 0.5 µg/mL and positive cefoxitin screens into our algorithm.

Results
Compared with accepting the VITEK 2 AES interpretation, PBP2a testing substantially improved the accuracy of mecA-mediated resistance classification in both scenarios, especially for the ∼4.7% of isolates with oxacillin MICs ≤0.5 µg/mL and positive cefoxitin screens.

Conclusions
Although detection of mecA or PBP2a is the gold standard for assessment of β-lactam resistance in staphylococci, targeting a subset of isolates for mecA or PBP2a testing based on phenotypic AST results that predict an increased risk of misclassification may be a pragmatic, labor- and cost-saving approach.
Post–Lung Transplantation Outcomes and Ex Vivo Histopathological Findings in Severe Post-Covid-19 Pulmonary Disease—A Single-Center Experience
Authors: Javaid Hana , Nigo Masayuki , Zhao Bihong , Trujillo Daniel Ocazionez , Hasbun Rodrigo , Ostrosky-Zeichner Luis , Patel Manish , Jyothula Soma 
Published: August 2022

Abstract

Background
A significant proportion of patients with severe and persistent coronavirus disease 2019 (COVID-19) require continuous ventilatory support and occasional extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS). Lung transplantation is a treatment option for patients who develop severe ARDS.

Methods
Our lung transplant database was retrospectively reviewed for patients who underwent lung transplantation for COVID-19 pulmonary disease at Memorial Hermann Hospital, Texas Medical Center, Houston, Texas, from January 2020 to March 2022. We evaluated outcomes of patients who were followed in our clinic at least 6 months post-transplant. Pretransplant patient characteristics, COVID-19-related treatment, histopathology results, and postdischarge course were evaluated.

Results
Among a total of 13 lung transplant recipients, 6 consecutive patients were identified who had a minimum of 6 months of follow-up post–lung transplantation. The average age of patients was 55 years, with a male predominance. The median time to transplantation was 111 days. All 6 patients had significant postinfectious complications due to COVID-19 before transplant. Histopathological findings from explanted lungs showed a predominance of fibrotic change. There were no reported cases of rejection or graft dysfunction. 5 patients had minimal to no post-transplant infectious complications. One patient died 218 days post-transplant from infectious complications.

Conclusions
Five out of six lung transplant recipients at our institution have demonstrated excellent long-term outcomes after index hospitalization, for a mean follow-up of 13 months post–lung transplantation. Lung transplantation for lung fibrosis due to COVID-19 is an acceptable salvage treatment option. Larger studies are warranted to confirm these findings.
SARS-CoV-2 immunity and vaccine strategies in people with HIV
Authors: Mullender Claire , da Costa Kelly A S , Alrubayyi Aljawharah , Pett Sarah L , Peppa Dimitra 
Published: August 2022

Abstract
Current severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines, based on the ancestral Wuhan strain, were developed rapidly to meet the needs of a devastating global pandemic. People living with Human Immunodeficiency Virus (PLWH) have been designated as a priority group for SARS-CoV-2 vaccination in most regions and varying primary courses (two- or three-dose schedule) and additional boosters are recommended depending on current CD4+ T cell count and/or detectable HIV viraemia. From the current published data, licensed vaccines are safe for PLWH, and stimulate robust responses to vaccination in those well controlled on antiretroviral therapy and with high CD4+ T cell counts. Data on vaccine efficacy and immunogenicity remain, however, scarce in PLWH, especially in people with advanced disease. A greater concern is a potentially diminished immune response to the primary course and subsequent boosters, as well as an attenuated magnitude and durability of protective immune responses. A detailed understanding of the breadth and durability of humoral and T cell responses to vaccination, and the boosting effects of natural immunity to SARS-CoV-2, in more diverse populations of PLWH with a spectrum of HIV-related immunosuppression is therefore critical. This article summarizes focused studies of humoral and cellular responses to SARS-CoV-2 infection in PLWH and provides a comprehensive review of the emerging literature on SARS-CoV-2 vaccine responses. Emphasis is placed on the potential effect of HIV-related factors and presence of co-morbidities modulating responses to SARS-CoV-2 vaccination, and the remaining challenges informing the optimal vaccination strategy to elicit enduring responses against existing and emerging variants in PLWH.
The renaissance and enlightenment ofMarchantiaas a model system
Authors: Bowman John L , Arteaga-Vazquez Mario , Berger Frederic , Briginshaw Liam N , Carella Philip , Aguilar-Cruz Adolfo , Davies Kevin M , Dierschke Tom , Dolan Liam , Dorantes-Acosta Ana E , Fisher Tom J , Flores-Sandoval Eduardo , Futagami Kazutaka , Ishizaki Kimitsune , Jibran Rubina , Kanazawa Takehiko , Kato Hirotaka , Kohchi Takayuki , Levins Jonathan , Lin Shih-Shun , Nakagami Hirofumi , Nishihama Ryuichi , Romani Facundo , Schornack Sebastian , Tanizawa Yasuhiro , Tsuzuki Masayuki , Ueda Takashi , Watanabe Yuichiro , Yamato Katsuyuki T , Zachgo Sabine 
Published: August 2022

AbstractThe liverwort Marchantia polymorpha has been utilized as a model for biological studies since the 18th century. In the past few decades, there has been a Renaissance in its utilization in genomic and genetic approaches to investigating physiological, developmental, and evolutionary aspects of land plant biology. The reasons for its adoption are similar to those of other genetic models, e.g. simple cultivation, ready access via its worldwide distribution, ease of crossing, facile genetics, and more recently, efficient transformation, genome editing, and genomic resources. The haploid gametophyte dominant life cycle of M. polymorpha is conducive to forward genetic approaches. The lack of ancient whole-genome duplications within liverworts facilitates reverse genetic approaches, and possibly related to this genomic stability, liverworts possess sex chromosomes that evolved in the ancestral liverwort. As a representative of one of the three bryophyte lineages, its phylogenetic position allows comparative approaches to provide insights into ancestral land plants. Given the karyotype and genome stability within liverworts, the resources developed for M. polymorpha have facilitated the development of related species as models for biological processes lacking in M. polymorpha.
Extracellular vesicle fusion visualized by cryo-electron microscopy
Authors: Morandi Mattia I , Busko Petro , Ozer-Partuk Efrat , Khan Suman , Zarfati Giulia , Elbaz-Alon Yael , Abou Karam Paula , Napso Shogan Tina , Ginini Lana , Gil Ziv , Regev-Rudzki Neta , Avinoam Ori 
Published: August 2022

Abstract
Extracellular vesicles (EVs) transfer bioactive molecules between cells in a process reminiscent of enveloped viruses. EV cargo delivery is thought to occur by protein-mediated and pH-dependent membrane fusion of the EV and the cellular membrane. However, there is a lack of methods to identify the fusion proteins and resolve their mechanism. We developed and benchmarked an in vitro biophysical assay to investigate EV membrane fusion. The assay was standardized by directly comparing EV and viral fusion with liposomes. We show that EVs and retroviruses fuse with liposomes mimicking the membrane composition of the late endosome in a pH- and protein-dependent manner. Moreover, we directly visualize the stages of membrane fusion using cryo-electron tomography. We find that, unlike most retroviruses, EVs remain fusogenic after acidification and reneutralization. These results provide novel insights into the EV cargo delivery mechanism and an experimental approach to identify the EV fusion machinery.
Estimation of Discrete Games with Weak Assumptions on Information
Authors: Magnolfi Lorenzo , Roncoroni Camilla 
Published: August 2022

Abstract
We propose a method to estimate static discrete games with weak assumptions on the information available to players. We do not fully specify the information structure of the game but allow instead for all information structures consistent with players knowing their own payoffs. To make this approach tractable, we adopt as a solution concept Bayes correlated equilibrium (BCE). We characterize the sharp identified set under BCE and unrestricted equilibrium selection, and find that in simple games with limited variation in covariates identified sets are informative. In an application, we estimate a model of entry in the Italian supermarket industry and quantify the effect of large malls on local supermarkets. Estimates and predictions differ from those obtained under more restrictive assumptions.
Echo Chambers
Authors: Cookson J Anthony , Engelberg Joseph E , Mullins William 
Published: August 2022

AbstractWe find evidence of selective exposure to confirmatory information among 400,000 users on the investor social network StockTwits. Self-described bulls are five times more likely to follow a user with a bullish view of the same stock than are self-described bears. Consequently, bulls see 62 more bullish messages and 24 fewer bearish messages than bears do over the same 50-day period. These “echo chambers” exist even among professional investors and are strongest for investors who trade on their beliefs. Finally, beliefs formed in echo chambers are associated with lower ex post returns, more siloing of information, and more trading volume.
Navigating the Intersection of Scepticism, Gender Blindness, and Ethnocentricity in the Asylum Tribunal: the Urgent Case For Empathy Enhancement
Authors: O’Nions Helen 
Published: August 2022

Abstract
Adopting a critical legal studies position, informed by procedural justice theory, this article argues that the intersection of scepticism with ethnocentric and gender-blind expectations of behaviour from tribunal judges impacts the fairness of proceedings, to the particular detriment of women asylum-seekers in the UK. Procedural justice theorists argue that fair procedures help court users to accept adverse outcomes. Yet an attempt to apply these principles to the asylum tribunal where there is no common experience and where decision-making occurs within a culture of disbelief proves futile. This analysis is informed by the experiences of 14 women who appealed an adverse asylum decision before the tribunal. It is evident that whilst judicial discretion allows judges to make procedural enhancements, this leads to inconsistency (itself a marker of unfairness) and the opportunity for an appellant to rebut assumptions through meaningful participation is rarely available. It is argued that principles of procedural justice need to be tailored in the specific context of asylum. Empathy-informed reasoning is urgently required. This needs to be embedded, through training, guidelines, and greater accountability. Without such enhancement, the tribunal appears to lack impartiality and serves only to replicate the flaws of initial decision-making.