bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topographic Hotspots of Southern Ocean Eddy Upwelling
Authors: Yung Claire K. , Morrison Adele K. , Hogg Andrew McC. 
Published: July 2022

The upwelling of cold water from the depths of the Southern Ocean to its surface closes the global overturning circulation and facilitates uptake of anthropogenic heat and carbon. Upwelling is often conceptualised in a zonally averaged framework as the result of isopycnal flattening via baroclinic eddies. However, upwelling is zonally non-uniform and occurs in discrete hotspots near topographic features. The mechanisms that facilitate topographically confined eddy upwelling remain poorly understood and thus limit the accuracy of parameterisations in coarse-resolution climate models.Using a high-resolution global ocean sea-ice model, we calculate spatial distributions of upwelling transport and energy conversions associated with barotropic and baroclinic instability, derived from a thickness-weighted energetics framework. We find that five major topographic hotspots of upwelling, covering less than 30% of the circumpolar longitude range, account for up to 76% of the southward eddy upwelling transport. The conversion of energy into eddies via baroclinic instability is highly spatially correlated with upwelling transport, unlike the barotropic energy conversion, which is also an order of magnitude smaller than the baroclinic conversion. This result suggests that eddy parameterisations that quantify baroclinic energy conversions could be used to improve the simulation of upwelling hotspots in climate models. We also find that eddy kinetic energy maxima are found on average 110 km downstream of upwelling hotspots in accordance with sparse observations. Our findings demonstrate the importance of localised mechanisms to Southern Ocean dynamics.
A Result of Accidental Noise Pollution: Acoustic Flowmeters Emit 28 kHz Pulses That May Affect Harbor Porpoise Hearing
Authors: Schaffeld Tobias , Schnitzler Joseph G. , Ruser Andreas , Baltzer Johannes , Schuster Max , Siebert Ursula 
Published: July 2022

Large rivers like the Elbe or the Weser are periodically entered by harbor porpoises of the North Sea. They may even move 97 km upstream to the port of Hamburg, where their presence is highest in spring. This migration is believed to be related to important anadromous prey species travelling upstream for spawning. An acoustic flowmeter in the port of Hamburg emits signals in the hearing range of harbor porpoises. The pulses have a duration of 0.2 ms, a peak frequency of 28 kHz, a source level of 210 dB re 1 µPa and an inter-pulse interval of 4.2 s. The signals are continuously emitted from both sides of the river at a location where the river is 400 m wide. We evaluated the potential of these signals to induce temporary threshold shift (TTS) in harbor porpoise hearing. Hearing tests with a harbor porpoise in human care were conducted to determine TTS onset. We modelled the acoustic field based on underwater noise measurements. The acoustic flowmeters emit pulses in a highly directional beam with a source level high enough for inducing TTS in harbor porpoises by a single exposure up to a distance of approximately 72 m. The received cumulative sound exposure levels for harbor porpoises travelling along the flowmeters are mainly dependent on the timing and distance to the sound source. Accordingly, a close approach to the flowmeter at the time of transmission should be prevented. This could be the case, if vessels force harbor porpoises to displace closer to the flowmeters. We therefore suggest to decrease acoustic flowmeter source levels. This case study emphasizes the need for a mandatory authorization process prior to the use of underwater sound for any purpose with potential effects on aquatic life. Such an authorization process should carefully consider potential effects for target and non-target species.
Slope Undercurrent in the Northwestern South China Sea Beneath the Winter Western Boundary Current
Authors: Shen Junqiang , Fang Wendong , Li Li , Qiu Yun , Xiao Zheng , Zhang Junpeng , Guo Xiaogang 
Published: July 2022

We herein report the observation of a slope undercurrent beneath the winter western boundary current of the northwestern South China Sea (SCS), and its spatiotemporal variation. The possible underlying dynamics are also discussed. In situ observations reveal that the northeastward undercurrent is located above the upper slope with a core velocity exceeding 20 cm/s, which extends from 200 m to 800 m in depth with a width of 30–50 km and an along-slope length of approximately 200 km in deep winter of 2006-2007, and is characterized with interseasonal and interannual variabilities. The existence of this undercurrent is also supported by Hybrid Coordinate Ocean Model (HYCOM) results. We find that the slope undercurrent is probably driven by the along-slope pressure gradient associated with the sea level set-up off the continental slope of south Hainan Island and modulated by mesoscale eddies and Rossby waves. This study will renew our knowledge of the deep slope currents in the northwestern SCS.
Secular Trends of Incidence, Prevalence, and Healthcare Economic Burden in ANCA-Associated Vasculitis: An Analysis of the 2002–2018 South Korea National Health Insurance Database
Authors: Ahn Sung Soo , Lim Hyunsun , Lee Chan Hee , Park Yong-Beom , Park Jin-Su , Lee Sang-Won 
Published: July 2022

ObjectivesThe incidence and prevalence of AAV in Asia remain poorly understood, especially in a nationwide setting. This study investigated the incidence, prevalence, and healthcare burden of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in South Korea by analyzing a national database.MethodsThis study included patients with AAV identified from the National Health Insurance Service Database of South Korea from 2002 to 2018. Patients were diagnosed with AAV in a general or tertiary hospital and were registered in the individual payment beneficiaries program or were prescribed glucocorticoids. A calendar-based meteorological definitions were adopted to assess the differences in the incidence of AAV according to season. The average healthcare expenditure and patient outcomes of mortality and end-stage renal disease (ESRD) in patients with AAV were compared to 1:10 age, sex and residential area matched controls.ResultsA total of 2,113 patients [708, 638, and 767 with microscopic polyangiitis (MPA), granulomatosis with polyangiitis, and eosinophilic granulomatosis with polyangiitis, respectively] were identified. The annual incidence and prevalence of AAV increased continuously, and MPA being the most common disease subtype after 2015. The highest incidence and prevalence of AAV was 0.48/100,000 person-years (PY) and 2.40/100,000 PY in 2017 and 2018, respectively. There were no significant differences in monthly and seasonal incidence of AAV. The average expense of medical care, overall mortality, and ESRD rates of patients with AAV were higher in patients with AAV than in controls, especially in the case of MPA.ConclusionAn increasing trend of AAV diagnosis observed is consistent with the evidence that AAV is more common in recent years; however, a relatively lower incidence and prevalence was observed compared to that in Western countries. The higher medical cost and rates of mortality and ESRD in AAV emphasize the early recognition and implementation of optimal treatment for these patients.
Main Pathological Changes of Benign Ureteral Strictures
Authors: Tan Jiang , Yu Zhuoyuan , Ling Xinyi , Qiu Guoping , Yang Xin , Tang Yi , Yang Dong , Yang Mei , Gao Fei 
Published: July 2022

ObjectiveTo identify the pathological classification of benign ureteral strictures according to the histological features and explore the relationship between various pathological types and inflammatory cells, fibroblasts, and collagen.Patients and MethodsThirty one specimens from patients diagnosed with ureteral strictures between 2013 and 2021 were included and classified according to the histopathological characteristics. The number of fibroblasts and inflammatory cells was counted, and the proportion of type I and type III collagen in ureteral stricture tissues was detected by picrosirius red staining.ResultsWe identified three types of benign ureteral strictures in 31 specimens: inflammatory cell infiltration (n= 10, 32%), fibroplasia (n= 14, 45%), and hyalinization (n= 7, 23%), with significant differences in obstruction history and hydronephrosis grades among the three types. The number of inflammatory cells (lymphocytes, neutrophils and eosinophils) was significantly lower in hyalinization ureteral strictures than in the other two types (p&lt; 0.05). The number of foreign-body giant cells associated with foreign-body reactions increased significantly in suture-induced ureteral strictures (p&lt; 0.05). Fibroplasia type had the largest number of fibroblasts, whereas the other two types had smaller numbers. The results of type I and III collagen analysis showed that type I and III collagen were the most abundant in hyalinization among all ureteral stricture types (p&lt; 0.05). Compared to ureteral strictures, the content of type I and III collagen in atresia increased significantly (p&lt; 0.05).ConclusionCommon pathological types of benign ureteral strictures include inflammatory cell infiltration, fibroplasia, and hyalinization. Changes in type I and III collagen, inflammatory cells, and fibroblasts in different pathological types may be related to the progression of ureteral strictures.
The Effect of Hydroxychloroquine on Residual Proteinuria in Patients With Immunoglobulin A Nephropathy: A Retrospective Study Based on Propensity Score Matching
Authors: Liu Mijia , Bian Xueyan , Wang Li , Li Guisen 
Published: July 2022

BackgroundThere is insufficient evidence to support the use of hydroxychloroquine (HCQ) in Immunoglobulin A nephropathy (IgAN) patients with high residual proteinuria in spite of 6-month supportive treatment combined with corticosteroids (P) and/or immunosuppressives (IM). This study aims to explore the effect of HCQ on residual proteinuria in IgAN.Materials and MethodsThis is a retrospective study. IgAN patients who had residual proteinuria ≥0.3 g/24 h after 6-month treatment by renin-angiotensin system inhibitors (RASI) + P ± IM were included. Groups were divided based on the different regimens and then matched by the propensity score matching method. The primary outcome was defined as the cumulative frequency of residual proteinuria reduction ≥30%.ResultsRASI (n = 183), HCQ + RASI (n = 59), RASI + P ± IM (n = 145), and HCQ + RASI + P ± IM (n = 38) groups were included. HCQ + RASI group had a higher level of residual proteinuria and a worse renal function than those in the RASI group. The renal function was worse in the HCQ + RASI + P ± IM group than that in the control group, but residual proteinuria levels were similar. After matching, there were 40 patients in the first two groups and 29 patients in the latter two groups, respectively. The cumulative frequency of residual proteinuria reduction ≥30% in HCQ + RASI + P ± IM group was higher than that in control group (86.2% vs. 62.1%, χ2 = 6.397, p = 0.011). HCQ combination treatment was one of independent factors.ConclusionThe addition of HCQ treatment can effectively reduce the residual proteinuria in IgAN patients previously treated with supportive treatment combined with P and IM treatment and the cumulative frequency of effective reduction of residual proteinuria can reach 86.2%.
18F-FDG /18F-Choline Dual-Tracer PET Behavior and Tumor Differentiation in HepatoCellular Carcinoma. A Systematic Review
Authors: Ghidaglia Jérôme , Golse Nicolas , Pascale Alina , Sebagh Mylène , Besson Florent L. 
Published: July 2022

BackgroundPost-operative recurrence remains the strongest prognostic factor of resected hepatocellular carcinoma (HCC), making the accurate selection of patients with curable HCC a crucial issue. PET imaging combining both 18F-FDG and fatty acid synthase (FAS) radiotracers—such as Choline—has shown its interest for the initial staging and therapeutic management of patients with HCC, but its use is still not consensual. Importantly, the very first dual-tracer PET studies suggested 18F-FDG/FAS PET behavior be linked to the degree of differentiation of HCC, a major predictive factor of post-operative recurrence. Although this key molecular imaging concept may impact how dual-tracer PET will be used in early-stage HCC, its level of evidence remains largely unexplored. In this study, we conducted a systematic review of the available evidence-based data to clarify the relevance of dual 18F-FDG/18F-Choline PET in characterizing the degree of differentiation of HCC tumors.MethodsA systematic search of the PubMed/Medline and Embase databases was performed up to November 2021. A systematic review of the dual-tracer 18F-FDG/18F-Choline PET behavior of histology-proven HCC according to their degree of differentiation was conducted. The overall quality of the included studies was critically assessed based on the STROBE guidelines. Information on study date, design, patient cohort characteristics, grade of differentiation of HCC tumors, and the dual-tracer PET behavior per HCC was independently extracted and summarized.ResultsFrom 440 records initially available, 6 full-text articles (99 histology-proven HCC) provided dual-tracer 18F-FDG/18F-Choline PET behavior per HCC tumor grade were included in the systematic review. Based on our analysis, 43/99 HCCs were reported to be well-differentiated, and 56/99 HCCs were reported to be less-differentiated tumors. In the well-differentiated subgroup, more than half were exclusively positive for 18F-Choline (51%), whereas 39% were positive for both 18F-FDG and 18F-Choline. In the less-differentiated subgroup, 37% of HCC patients were positive exclusively for FDG, 36% were positive for both 18F-FDG and 18F-Choline, and 25% were positive exclusively for 18F-Choline.ConclusionThe 18F-FDG/18F-Choline dual-tracer PET behavior of uptake shows high overlap between well- and less differentiated HCC, making the characterization of tumors challenging based on such PET combination alone. Given our growing knowledge of the molecular complexity of HCC, further studies are necessary to refine our understanding of radiotracers’ behavior in this field and improve the usefulness of PET imaging in the clinical decision process of HCC.
Gut Dysbiosis and Intestinal Barrier Dysfunction Promotes IgA Nephropathy by Increasing the Production of Gd-IgA1
Authors: Tang Yuyan , Zhu Yifan , He Haidong , Peng Yinshun , Hu Ping , Wu Jiajun , Sun Weiqian , Liu Ping , Xiao Yong , Xu Xudong , Wei Minggang 
Published: July 2022

BackgroundImmunoglobulin A nephropathy (IgAN) is the most common type of primary glomerular disease in adults worldwide. Several studies have reported that galactose-deficient IgA1 (Gd-IgA1) is involved in the pathogenesis of IgAN.MethodsThirty-five patients with IgAN diagnosed with renal biopsy for the first time served as the experimental group, who were hospitalized in our department. Twenty normal healthy cases in the physical examination center of our hospital served as the control group. Then the levels of Gd-IgA1 in serum and urine, and intestinal mucosal barrier injury indexes [diamine oxidase (DAO), serum soluble intercellular adhesion molecule-1 (sICAM-1), D-lactate (D-LAC), and lipopolysaccharide (LPS)] and inflammatory factors [interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)] in the serum samples were detected. Fecal samples were collected to detect intestinal microbiota using 16 s rDNA sequencing. Then, we assessed possible correlations among clinical and laboratory findings.ResultsIn patients with IgAN, the levels of Gd-IgA1 both in the serum and urine were higher than that of the healthy control. Furthermore, urine Gd-IgA1 level was positively correlated with the serum creatinine level, 24 h urine protein, and M, S, and T parameters in the Oxford classification. ROC curve analysis showed that urine Gd-IgA1 has a greater diagnostic value (AUC = 0.9714, 95% CI, 0.932–1; P &lt; 0.0001) for IgAN. The best cutoff value for urine Gd-IgA1 was 0.745 ng·l/ml·μmol (sensitivity, 94%; specificity, 95%). The intestinal mucosal barrier damage indexes (DAO, sICAM-1, D-LAC, and LPS) were increased in the patients with IgAN, which were positively correlated with Gd-IgA1 levels (P &lt; 0.05) both in serum and urine. The levels of inflammatory factors in the patients with IgAN were increased. 16 s rDNA analysis showed that the intestinal microbiota in these patients was disordered compared to that observed in the healthy subjects. Actinobacteria, Bifidobacterium, Blautia, Bifidobacteriaceae, and Bifidobacteriales were decreased and Shigella was increased in IgAN. The decreased populations of these flora were negatively and significantly correlated with urine Gd-IgA1 and the levels of DAO, sICAM-1, D-LAC, and LPS.ConclusionThe urine Gd-IgA1 levels may be a non-invasive biological marker for evaluating kidney injury in IgAN. Gut flora dysbiosis and intestinal barrier dysfunction may be involved in Gd-IgA1 expression.
Exome Sequencing of a Portuguese Cohort of Frontotemporal Dementia Patients: Looking Into the ALS-FTD Continuum
Authors: Tábuas-Pereira Miguel , Santana Isabel , Gibbons Elizabeth , Paquette Kimberly , Almeida Maria Rosário , Baldeiras Inês , Bras Jose , Guerreiro Rita 
Published: July 2022

IntroductionFrontotemporal dementia (FTD) is considered to be part of a continuum with amyotrophic lateral sclerosis (ALS). Many genes are associated with both ALS and FTD. Yet, many genes associated with ALS have not been shown to cause FTD. We aimed to study a Portuguese cohort of FTD patients, searching for variants in genes associated with both FTD and/or ALS.MethodsWe included 57 thoroughly characterized index FTD patients from our memory clinic, who were not carriers of pathogenic variants in GRN, MAPT or C9orf72. We performed exome sequencing and 1) prioritized potential FTD and ALS causing variants by using Exomiser to annotate and filter results; and 2) looked specifically at rare variability in genes associated with FTD (excluding GRN, MAPT and C9ORF72) and/or ALS.ResultsWe identified 13 rare missense variants in 10 patients (three patients had two variants) in the following genes: FUS, OPTN, CCNF, DCTN1, TREM2, ERBB4, ANG, CHRNA4, CHRNB4 and SETX. We found an additional frameshift variant on GLT8D1 in one patient. One variant (ERBB4 p.Arg1112His) gathered enough evidence to be classified as likely pathogenic by the ACMG criteria.DiscussionWe report, for the first time, an expanded study of genes known to cause FTD-ALS, in the Portuguese population. Potentially pathogenic variants in ERBB4, FUS, SETX, ANG, CHRNA4 and CHRNB4 were identified in FTD patients. These findings provide additional evidence for the potential role of rare variability in ALS-associated genes in FTD, expanding the genetic spectrum between the two diseases.
Transcranial Magnetic Stimulation for Long-Term Smoking Cessation: Preliminary Examination of Delay Discounting as a Therapeutic Target and the Effects of Intensity and Duration
Authors: Shevorykin Alina , Carl Ellen , Mahoney Martin C. , Hanlon Colleen A. , Liskiewicz Amylynn , Rivard Cheryl , Alberico Ronald , Belal Ahmed , Bensch Lindsey , Vantucci Darian , Thorner Hannah , Marion Matthew , Bickel Warren K. , Sheffer Christine E. 
Published: July 2022

BackgroundRepetitive transcranial magnetic stimulation (rTMS) is a novel treatment for smoking cessation and delay discounting rate is novel therapeutic target. Research to determine optimal therapeutic targets and dosing parameters for long-term smoking cessation is needed. Due to potential biases and confounds introduced by the COVID-19 pandemic, we report preliminary results from an ongoing study among participants who reached study end prior to the pandemic.MethodsIn a 3 × 2 randomized factorial design, participants (n = 23) received 900 pulses of 20 Hz rTMS to the left dorsolateral prefrontal cortex (PFC) in one of three Durations (8, 12, or 16 days of stimulation) and two Intensities (1 or 2 sessions per day). We examined direction and magnitude of the effect sizes on latency to relapse, 6-month point-prevalence abstinence rates, research burden, and delay discounting rates.ResultsA large effect size was found for Duration and a medium for Intensity for latency to relapse. Increasing Duration increased the odds of abstinence 7–8-fold while increasing Intensity doubled the odds of abstinence. A large effect size was found for Duration, a small for Intensity for delay discounting rate. Increasing Duration and Intensity had a small effect on participant burden.ConclusionFindings provide preliminary support for delay discounting as a therapeutic target and for increasing Duration and Intensity to achieve larger effect sizes for long-term smoking cessation and will provide a pre-pandemic comparison for data collected during the pandemic.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT03865472].
The Predictive Potential of Altered Voxel-Based Morphometry in Severely Obese Patients With Meibomian Gland Dysfunction
Authors: Li Le-Yan , Wang Yuan-Yuan , Gao Jun-Wei , Chen Jun , Kang Min , Ying Ping , Liao Xulin , Wang Yixin , Zou Jie , Su Ting , Wei Hong , Shao Yi 
Published: July 2022

ObjectiveTo investigate voxel-based morphometry (VBM) by using magnetic resonance imaging (MRI) in meibomian gland dysfunction patients with severe obesity (PATs) and to explore the application of VBM in the early diagnosis, prevention of cognitive impairment and targeted treatment of this disease.MethodsSixteen PATs and 12 healthy controls (HCs) were enrolled and underwent MRI. Whole-head images were analyzed using VBM and data were compared between groups using an independent samples t-test. Receiver operating characteristic (ROC) curves were utilized to assess the diagnostic value of this approach. Mini-mental state examination (MMSE) scores were used to assess cognitive impairment and were analyzed using an independent samples t-test.ResultsCompared with HCs, the VBM values in PATs were reduced in the left cerebellum and right thalamus but increased in the right brainstem, right precuneus and right paracentral lobule. The results of ROC curve analysis indicated that VBM may be useful in meibomian gland disease diagnosis. Comparison of MMSE scores between groups showed mild cognitive impairment in PATs.ConclusionPATs showed altered VBM values in some brain areas. These findings may provide information about the pathophysiology of meibomian gland dysfunction and may help to explain the underlying mechanisms of clinical manifestations in PATs, such as cognitive impairment. Abnormal VBM values in these brain areas may serve as predictive factors for development of meibomian gland disease in severely obese people and as indicators for individualized treatment.