bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intense long‐term training impairs brain health compared with moderate exercise: Experimental evidence and mechanisms
Authors: Sangüesa Gemma , Batlle Montserrat , Muñoz‐Moreno Emma , Soria Guadalupe , Alcarraz Anna , Rubies Cira , Sitjà‐Roqueta Laia , Solana Elisabeth , Martínez‐Heras Eloy , Meza‐Ramos Aline , Amaro Sergi , Llufriu Sara , Mont Lluís , Guasch Eduard 
Published: October 2022

AbstractThe consequences of extremely intense long‐term exercise for brain health remain unknown. We studied the effects of strenuous exercise on brain structure and function, its dose‒response relationship, and mechanisms in a rat model of endurance training. Five‐week‐old male Wistar rats were assigned to moderate (MOD) or intense (INT) exercise or a sedentary (SED) group for 16 weeks. MOD rats showed the highest motivation and learning capacity in operant conditioning experiments; SED and INT presented similar results. In vivo MRI demonstrated enhanced global and regional connectivity efficiency and clustering as well as a higher cerebral blood flow (CBF) in MOD but not INT rats compared with SED. In the cortex, downregulation of oxidative phosphorylation complex IV and AMPK activation denoted mitochondrial dysfunction in INT rats. An imbalance in cortical antioxidant capacity was found between MOD and INT rats. The MOD group showed the lowest hippocampal brain‐derived neurotrophic factor levels. The mRNA and protein levels of inflammatory markers were similar in all groups. In conclusion, strenuous long‐term exercise yields a lesser improvement in learning ability than moderate exercise. Blunting of MOD‐induced improvements in CBF and connectivity efficiency, accompanied by impaired mitochondrial energetics and, possibly, transient local oxidative stress, may underlie the findings in intensively trained rats.
An Accuracy Comparison of Minimally Invasive Transclavicular‐Transcortical Drilling with Free‐Hand, C‐Shape and Assembly‐Type Guide Device: An In Vitro Study
Authors: Zhang Hongtao , Fan Tiancheng , Wu Xiaowei , Li Lutao , Li Wenrui , Lin Lijun , Li Jianyi 
Published: October 2022

ObjectivesEnsuring the accuracy of transclavicular‐transcoracoid drilling in the anatomical reconstruction of the coracoclavicular ligament complex with minimally invasive incisions remains a major problem for inexperienced surgeons. The purpose of this study was to design an assembly guide device for transclavicular‐transcoracoid drilling with minimally invasive incisions, to manufacture the finished product, and to compare its feasibility and accuracy with the existing C‐shape guide devices and free‐hand techniques.MethodsAn assembly‐type guide device was designed and produced using computer‐aided design and three‐dimensional printing. The specimen data of 54 human shoulders from 27 gross specimen (14 males and 13 females) treated by free‐hand drilling, C‐shape device drilling, and assembly‐type guide device drilling from October 2018 to January 2021 were analyzed in a controlled laboratory study. Fifty‐four human shoulder specimens were randomly assigned into free‐hand (n = 18), C‐shape (n = 18), and assembly (n = 18) groups by drawing lots for transclavicular‐transcoracoid drilling by three inexperienced surgeons. After the drilling procedure was completed and the devices were removed, the operation outcomes were assessed and evaluated. Distances from the tunnel edge to the coracoid's medial (dm) and lateral (dl) edges, operation time, and tunnel location zones on the coracoid's inferior surface of all specimens in the three groups were measured to evaluate the surgical accuracy and efficiency.ResultsAll specimens in the three groups completed the drilling operation successfully and were correctly measured. The distance differences (dd) between dm and dl in the free‐hand, C‐shape, and assembly groups were 3.2 ± 1.8 mm, 1.8 ± 1.0 mm, 1.0 ± 0.8 mm, respectively. The dd of the free‐hand group was higher than that of the other two groups (p < 0.001). The tunnel exit points on the inferior coracoid surface located in undesired zones were six (33%), one (6%), and zero in the free‐hand group, C‐shape group, and assembly‐type group, respectively (p = 0.012). The operation time in the free‐hand, C‐shape, and assembly groups were 198 ± 36 s, 256 ± 64 s, and 353 ± 88 s, respectively. The operation time of each group significantly differed from that of the others (p < 0.001).ConclusionThe assembly‐type devices may be the first choice for inexperienced surgeons while both the C shape devices and assembly‐type guide devices achieved higher accuracy than free‐hand techniques.
Contextual desirability of strong men employing affiliative and aggressive humor
Authors: Brown Mitch , Brown Madeline R. , O'Neil Bridget A. 
Published: October 2022

AbstractWomen find men's upper body strength highly desirable, albeit primarily within short‐term mating contexts. This boundary implicates strength as possessing both costs and benefits in long‐term and short‐term mating contexts. The desirability of strength could be contingent upon whether the costs or benefits of strength are more salient through additional behavioral repertoires that signal a specific type of mating intent. Men's humor style could be one modality to infer costs and benefits, namely their interest in affiliative humor relative to aggressive humor. This study represents a synergistic replication of previous work investigating the desirability of strength and various humor styles in mating domains. Women evaluated the short‐term and long‐term desirability of a prospective mate manipulated to appear physically strong or weak and described using affiliative or aggressive humor. We replicated previous findings implicating affiliative humor as desirable in long‐term contexts and upper body strength in short‐term contexts. However, no interactive effects between these traits emerged. Results indicate that women's mate choices are multimodal and frequently involve evaluating the costs and benefits of various constellations of traits.
Pathways to depression: Dynamic associations between neural responses to appetitive cues in the environment, stress, and the development of illness
Authors: Weinberg Anna 
Published: October 2022

AbstractThis review focuses on research my colleagues and I have conducted on etiological pathways to depression. Much of this work has focused on the measurement of neural responses to appetitive cues, using two event‐related brain potential (ERP) components, the Late Positive Potential (LPP) and the Reward Positivity (RewP). Reductions in each of these components have been associated with current symptoms of depression, and in some cases have been shown to differentiate anxious from depressive phenotypes. In this review, I will describe three broad and related approaches we have taken in our research to address a series of interdependent issuess. The first attempts to understand different sources of variation in the LPP and RewP, and how these sources interact with one another. The second tries to identify whether variation in the processes measured by these ERP components might reflect a latent vulnerability to depression and its symptoms, that is evident prior to illness onset. And the third examines the possibility that the processes reflected in the LPP and RewP might play a mechanistic role in the development of depression.
The implications of seabed mining in the Area for the human right to health
Authors: Hamley Graham J. 
Published: October 2022

AbstractAs the prospect of seabed mining in the Area looms closer, much of the debate to date has focused on the prospects of economic gain versus environmental harm. This article contends that potential human health implications must also be considered, including threats to food safety and security and acceleration of global climate change. Through analysis of both scientific and legal literature, this article highlights several ways in which seabed mining may impact human health due to harm to marine biodiversity, threatening enjoyment of the right to health under international human rights law. Against this backdrop, this article reviews the draft regime for the exploitation phase of seabed mining, currently under development by the International Seabed Authority, and highlights two areas in which the regime is incompatible with the human right to health. These findings highlight potential for stronger alignment between the seabed mining and international human rights law regimes.
Beta‐lactam allergies, surgical site infections, and prophylaxis in solid organ transplant recipients at a single center: A retrospective cohort study
Authors: Mowrer Clayton , Lyden Elizabeth , Matthews Stephen , Abbas Anum , Bergman Scott , Alexander Bryan T. , Van Schooneveld Trevor C. , Stohs Erica J. 
Published: October 2022

AbstractBackgroundBeta‐lactam allergies (BLAs) are common in hospitalized patients, including transplant recipients. BLA is associated with decreased use of preferred surgical site infection (SSI) prophylaxis and increased SSIs, but this has not been studied in the transplant population.MethodsWe reviewed adult heart, kidney, and liver transplant recipients between January 1, 2016 and December 31, 2019 to characterize reported BLA and collect SSI prophylaxis regimens at time of transplant. We compared the use of preferred SSI prophylaxis and SSI incidence based on reported BLA status. Post hoc we collected antibiotic days of therapy (DOT) (excluding pneumocystis prophylaxis) in the 30‐day period posttransplant for patients without SSI. We utilized descriptive statistics for comparisons.ResultsOf 691 patients included (116 heart, 400 kidney, and 175 liver transplant recipients), 118 (17%) reported BLA. Rash and hives were the two most reported BLA reactions (36% and 24%), categorized as potential T‐cell mediated and IgE mediated, respectively. Preferred SSI prophylaxis was prescribed in 13 (11%) patients with BLA and 573 (92%) without BLA (p < .001). No difference could be detected in SSI incidence between BLA and non‐BLA patients (4.2 vs. 4.3%, p = 1.0). Of 659 without SSI, 169 (25.6%) received antibiotics within 30 days of transplant; mean antibiotic DOT for BLA and non‐BLA patients were 3.5 ± 8.0 versus 2.3 ± 5.8, p = .12.ConclusionBLA transplant recipients received nonpreferred SSI prophylaxis more frequently than non‐BLA recipients, but there was no difference in 30‐day SSIs between the groups. One‐fourth of solid organ transplant recipients received systemic antibiotics within 30 days of transplant.
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Ditauonium spectroscopy
Authors: d’Enterria David , Perez-Ramos Redamy , Shao Hua-Sheng 
Published: October 2022

AbstractWe examine the properties of ditauonium, an exotic atom consisting of a pair of opposite-sign $$\tau $$
τ
leptons bound together by the quantum electrodynamics (QED) interaction in a hydrogen-like state. The energy levels, decay modes and associated partial widths, as well as total widths and lifetimes of the ortho- and para-ditauonium states are calculated. Higher-order QED effects – including Lamb shifts, hyperfine splitting structure, and partial decay widths corrections – are incorporated up to approximately next-to-next-to-leading-order (NNLO) accuracy. Beyond the dominant diphoton and difermion decays, the rates of rare decay channels – including Dalitz, radiative, triple-photon, double-Dalitz, four-fermion, and neutrinos final states – are determined.
Ordovician cyclostratigraphy and astrochronology
Authors: Sinnesael Matthias 
Published: October 2022

Abstract
Cyclostratigraphy is an important tool for understanding astronomical climate forcing and for reconstructing geological time in sedimentary sequences, provided that an imprint of insolation variations caused by Earth's orbital eccentricity, obliquity and precession is preserved (Milankovitch forcing). Understanding astronomical climate forcing has proven fundamental for the study of Cenozoic climate systems and the construction of high-resolution continuous time scales (astrochronologies). Pre-Cenozoic astrochronologies face several challenges: (1) uncertainties in the deep-time astronomical solutions and parameters; (2) less complete and less well preserved strata; and (3) the sparsity of geochronologic anchor points. Consequently, Paleozoic astrochronologies are typically based on identification of the stable 405 kyr eccentricity cycle instead of shorter astronomical cycles. Here, a state-of-the-art review of Ordovician cyclostratigraphy and astrochronology is presented, as well as suggestions on their robust application in an Ordovician context. Ordovician astronomically driven climate dynamics are suggested to have influenced processes like glacial dynamics, sea-level variations and changes in biodiversity. Ordovician cyclostratigraphic studies can help to construct high-resolution numerical time scales, ideally in combination with high-quality radio-isotopic dating. As such, cyclostratigraphy is becoming an increasingly important part of an integrated stratigraphic approach to help disentangle Ordovician stratigraphy and palaeoenviromental changes.
A Phase II Clinical Trial of Nivolumab and Temozolomide for Neuroendocrine Neoplasms
Authors: Owen Dwight H. , Benner Brooke , Wei Lai , Sukrithan Vineeth , Goyal Ashima , Zhou Ye , Pilcher Carly , Suffren Sheryl-Ann , Christenson Gwen , Curtis Nancy , Jukich Megan , Schwarz Emily , Savardekar Himanshu , Norman Ruthann , Ferguson Sarah , Kleiber Barbara , Wesolowski Robert , Carson William E. , Otterson Gregory A. , Verschraegen Claire F. , Shah Manisha H. , Konda Bhavana 
Published: October 2022

AbstractPurpose:Treatment options are limited in patients with metastatic neuroendocrine neoplasms (NEN). We present the results for a phase II trial of combination nivolumab and temozolomide in patients with advanced NEN along with results of immune changes in peripheral blood.Patients and Methods:NCT03728361 is a nonrandomized, phase II study of nivolumab and temozolomide in patients with NEN. The primary endpoint was response rate using RECIST 1.1. Secondary endpoints included progression-free survival (PFS), overall survival (OS), and safety. Immune profiling was performed by mass cytometry to evaluate the effect on peripheral blood immune cell subsets.Results:Among all 28 patients with NEN, the confirmed response rate was 9/28 [32.1%, 95% confidence interval (CI): 15.9–52.4]. Of 11 patients with lung NEN, the response rate was 64% (n = 7); there was a significant difference in responses by primary tumor location (lung vs. others, P = 0.020). The median PFS was 8.8 months (95% CI: 3.9–11.1 months), and median OS was 32.3 months (95% CI: 20.7—not reached months). Exploratory blood immune cell profiling revealed an increase in circulating CD8+ T cells (27.9% ± 13.4% vs. 31.7% ± 14.6%, P = 0.03) and a decrease in CD4+ T cells (59.6% ± 13.1% vs. 56.5% ± 13.0%, P = 0.001) after 2 weeks of treatment. LAG-3–expressing total T cells were lower in patients experiencing a partial response (0.18% ± 0.24% vs. 0.83% ± 0.55%, P = 0.028). Myeloid-derived suppressor cell levels increased during the study and did not correlate with response.Conclusions:Combination nivolumab and temozolomide demonstrated promising activity in NEN.See related commentary by Velez and Garon, p. 691
Favorable Activity and Safety Profile of Memory-Enriched CD19-Targeted Chimeric Antigen Receptor T-Cell Therapy in Adults with High-Risk Relapsed/Refractory ALL
Authors: Aldoss Ibrahim , Khaled Samer K. , Wang Xiuli , Palmer Joycelynne , Wang Yan , Wagner Jamie R. , Clark Mary C. , Simpson Jennifer , Paul Jinny , Vyas Vibhuti , Chien Sheng-Hsuan , Stein Anthony , Pullarkat Vinod , Salhotra Amandeep , Al Malki Monzr M. , Aribi Ahmed , Sandhu Karamjeet , Thomas Sandra H. , Budde Lihua E. , Marcucci Guido , Brown Christine E. , Forman Stephen J. 
Published: October 2022

AbstractPurpose:A phase I/II study evaluating the safety and activity of memory-enriched CD19-directed chimeric antigen receptor (CD19-CAR) T cells in adults with relapsed/refractory B-cell acute lymphoblastic leukemia (ALL).Patients and Methods:In phase I, we tested sequentially two cell populations for CAR transduction: (i) central memory (Tcm) or (ii) naïve, stem, and central memory (Tn/mem) T cells. The study employed an activity constrained for toxicity design to determine the recommended phase II dose (RP2D), which was tested in phase II.Results:The Tcm cohort was closed early due to lack of activity. The 200 ×106 Tn/mem-derived CD19-CAR T-cell dose was found to be safe and active, and was declared the RP2D. At RP2D, 58 participants underwent leukapheresis and 46 received CD19-CAR T cells. Median age for treated participants was 38 years (range, 22–72). Twenty-nine (63%) participants had relapsed post-allogeneic hematopoietic cell transplantation (alloHCT), 18 (39%) had Philadelphia-like (Ph-like) genotype, and 16 (35%) had extramedullary disease (EMD) at lymphodepletion (LD). Three (7%) participants had grade 3 cytokine release syndrome (CRS), and none had grade ≥ 4 CRS. Eight (17%) participants had grade ≥ 3 neurotoxicity, including one fatal cerebral edema. Forty (87%) patients achieved complete remission (CR)/CR with incomplete hematologic recovery, 2 (4%) progressed, and 4 (9%) were unevaluable for response. Among 42 response-evaluable participants, 16/17 with Ph-like ALL and 13/15 with EMD at LD responded. Twenty-one (53%) responders underwent alloHCT consolidation, which was associated with improved relapse-free survival (adjusted HR = 0.16; 95% confidence interval, 0.05–0.48; P = 0.001).Conclusions:Tn/mem-derived CD19-CAR T cells were safe and active, including in Ph-like ALL and EMD.See related commentary by El Marabti and Abdel-Wahab, p. 694
Risk of Hypertensive Disorders in Pregnancy After Fresh and Frozen Embryo Transfer in Assisted Reproduction: A Population-Based Cohort Study With Within-Sibship Analysis
Authors: H. Petersen Sindre , Westvik-Johari Kjersti , Spangmose Anne Lærke , Pinborg Anja , Romundstad Liv Bente , Bergh Christina , Åsvold Bjørn Olav , Gissler Mika , Tiitinen Aila , Wennerholm Ulla-Britt , Opdahl Signe 
Published: October 2022

Background:
Frozen embryo transfer (frozen-ET) is increasingly common because of improved cryopreservation methods and elective freezing of all embryos. Frozen-ET is associated with higher risk of hypertensive disorders in pregnancy than both natural conception and fresh embryo transfer (fresh-ET), but whether this is attributable to parental factors or treatment is unknown.

Methods:
Using the Medical Birth Registries of Denmark (1994–2014), Norway, and Sweden (1988–2015), linked to data from national quality registries and databases on assisted reproduction, we designed a population-based cohort study with within-sibship comparison. We included 4 426 691 naturally conceived, 78 300 fresh-ET, and 18 037 frozen-ET singleton pregnancies, of which 33 209 sibships were conceived using different conception methods. Adjusted odds ratios (aOR) of hypertensive disorders in pregnancy for fresh-ET and frozen-ET versus natural conception with 95% CI were estimated using multilevel logistic regression, where random effects provided conventional population-level estimates and fixed effects gave within-sibship estimates. Main models included adjustment for birth year, maternal age, parity, and country.

Results:
Risk of hypertensive disorders in pregnancy was higher after frozen-ET compared to natural conception, both at population-level (7.4% versus 4.3%, aOR, 1.74 [95% CI, 1.61–1.89]) and within sibships (aOR, 2.02 [95% CI, 1.72–2.39]). For fresh-ET, risk was similar to natural conception, both at population-level (aOR, 1.02 [95% CI, 0.98–1.07]) and within sibships (aOR, 0.99 [95% CI, 0.89–1.09]).

Conclusions:
Frozen-ET was associated with substantially higher risk of hypertensive disorders in pregnancy, even after accounting for shared parental factors within sibships.
Systolic Blood Pressure Time in Target Range and Major Adverse Kidney and Cardiovascular Events
Authors: Buckley Leo F. , Baker William L. , Van Tassell Benjamin W. , Cohen Jordana B. , Alkhezi Omar , Bress Adam P. , Dixon Dave L. 
Published: October 2022

Background:
Whether time-in-target range (TTR) for systolic blood pressure (SBP) associates with adverse kidney and cardiovascular events remains incompletely understood.

Methods:

This study included participants in 2 clinical trials that compared intensive (<120 mm Hg) and standard (<140 mm Hg) SBP lowering. SBP-TTR for months 0 to 3 was calculated using therapeutic ranges of 110 to 130 mm Hg and 120 to 140 mm Hg for the intensive and standard arms, respectively. Adverse kidney events included the composite of dialysis, kidney transplant, serum creatinine >3.3 mg/dL, sustained eGFR <15 mL/(min·1.73 m
2
), or sustained eGFR decline >40%. Adverse cardiovascular events included myocardial infarction, stroke, heart failure, and cardiovascular death. Adjusted Cox proportional hazards regression models were used to estimate the association between SBP-TTR and kidney and cardiovascular events.

Results:

Participants with higher TTR were younger and less likely to have preexisting cardiovascular disease. Compared with participants with TTR of 0%, the risk of adverse kidney events was lower for participants with TTR of >0% to 43% (hazard ratio [95% CI], 0.57 [0.42–0.76];
P
<0.001), 43% to <70% (0.57 [0.42–0.78];
P
=0.001), 70% to <100% (0.53 [0.38–0.74];
P
<0.001), and 100% (0.33 [0.20–0.57];
P
<0.001) in fully adjusted models. The risk of major adverse cardiovascular events was lower for participants with TTR of >0% to 43% (0.66 [0.52–0.83];
P
=0.001), 43% to <70% (0.70 [0.55–0.90];
P
=0.005), 70% to <100% (0.65 [0.50–0.84];
P
=0.001), or 100% (0.56 [0.39–0.80];
P
=0.001) compared with those with TTR of 0%.

Conclusions:
Higher SBP-TTR associates with lower risks of adverse kidney and cardiovascular events in adults with hypertension. SBP-TTR may be a potential therapeutic target and quality metric.
Holy Healers in Rome
Authors: Lourié Basil , Lidova Maria 
Published: October 2022

Abstract
The article is dedicated to four saints represented in the Chapel of Holy Physicians in Santa Maria Antiqua church in Rome. Two saints are identified for the first time (Jonas and Procopius), one previously hypothetical identification is confirmed (Barachisius), and the meaning of the cult of St Dometius in Rome is discussed. The hagiographical dossier of Sts Jonas and Barachisius is examined in detail. Based on this examination, it is argued that the earliest recensions of their martyrdom must go back to the Syriac Chalcedonian archetype written in the 590s, which, in turn, derived from a Syriac “Nestorian” hagiographical work produced in sixth-century Iran and related to the mid-sixth-century rebellion of prince Anōšazād against his father Khosrow I. The Chalcedonian counterpart of this lost hagiographical work was paraphrased by Ferdowsi.
Introduction: The Production and Distribution of Sino-European Intercultural Books in China (1582–c.1823)
Authors: Standaert Nicolas 
Published: October 2022

Abstract
A unique characteristic of the cultural contacts between China and Europe in the seventeenth and eighteenth centuries is the intercultural circuit of books that was established: European books travelling to China, and in return Chinese books travelling to Europe. Within this circuit, a large number of intercultural books was translated and published in Chinese or in European languages, thus becoming the source material for new publications. This special issue of EAPS focuses on the Chinese pole of this cross-continental textual exchange, where the printing of Sino-European books was facilitated by the presence of a well-established print culture. By analysing a unique collection of these Sino-European books, the following two articles investigate their production and distribution from the late Ming until the mid-Qing period (1582–c.1823). As such, they provide insights into the emergence of an intercultural ‘book world’. The following introduction sets the scene for the two articles.