bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential expression of SLC30A10 and RAGE in mouse pups by early life lead exposure
Authors: Li Ning , Wen Liuding , Shen Yue , Li Tiange , Wang Tianlin , Qiao Mingwu , Song Lianjun , Huang Xianqing 
Published: October 2022

Abstract

It is well known that SLC30A10 and RAGE play a crucial role in regulating the transport and accumulation of Aβ plaques. Our previous studies have shown that early exposure to lead can cause cerebral damage to pups due to the accumulation of Aβ and the deposition of amyloid plaques. However, the effect of lead on the protein expression levels of SLC30A10 and RAGE remains unclear. This study aimed to verify that maternal exposure to lead-containing drinking water during pregnancy would affect the expression of SLC30A10 and RAGE proteins in mice offspring, further verifying the lead-induced neurotoxicity. Four groups of mice were exposed to 0 mM, 0.25 mM, 0.5 mM, and 1 mM of lead for 42 consecutive days from pregnancy to weaning, and the offspring mice were tested on postnatal day 21. The levels of lead in the blood, hippocampus, and cerebral cortex were examined; the learning and memory abilities of the mice were investigated using the Morris water maze; the expression levels of SLC30A10 and RAGE in the hippocampus and cerebral cortex were examined using Western blotting and immunofluorescence. The results showed that the lead concentration in the brain and blood of the mice increased along with the lead content of the mothers during the lead exposure period (P < 0.05). In the Morris water maze test, the spatial memory of the lead exposure group was lower than that of the control group (P < 0.05). Both Immunofluorescence and Western blot analysis showed that the hippocampal and cerebral cortex of the offspring were proportionally affected by differential levels of lead exposure. The expression levels of SLC30A10 were negatively correlated with lead doses (P < 0.05). Surprisingly, under the same conditions, the expression of RAGE in the hippocampus and cortex of offspring was positively correlated with lead doses (P < 0.05). SLC30A10 may play a differential role in aggravated Aβ accumulation and transportation compared with RAGE. A difference in RAGE and SLC30A10 expression in the brain could contribute to lead-induced neurotoxicity.
Machine learning research of bulimia nervosa based on diffusion tensor image
Authors: Zheng Linli , Jing Ma , Wang Yu , Wang Meiou , Liu Yang , Li Jin , Li Tao , Zhang Lan 
Published: October 2022

Abstract
Background
Bulimia nervosa is a type of eating disorder characterized by recurrent, uncontrollable, impulsive binge eating. No previous study selected diffusion tensor imaging as data features to conduct machine learning research on the diagnosis of bulimia nervosa. We tried to use machine learning methods to study the diagnosis of this disease and explore neurobiological markers .
Methods
This retrospective study examined 34 patients with bulimia nervosa and 34 healthy subjects. The selected characteristics were Fractional Anisotropy (FA), Axial Diffusivity (AD), Radial Diffusivity (RD) and Mean Diffusivity (MD). we used machine learning methods of support vector machines to distinguish bulimia nervosa and healthy controls.
Results
A total of 5 machine learning models were constructed. Classification effect of FA model and FA + MD + AD + RD model were acceptable. FA model classification effect was the best. The machine learning results of the five models were as follows: the area under the Receiver Operator Characteristic (ROC) curve of the FA model was 0.821, and the different brain regions were brainstem, temporal lobe, frontal lobe, inferior occipital gyrus, midbrain, middle frontal gyrus and caudate nucleus; MD model curve The lower area was 0.689, and the difference brain areas were posterior cerebellar lobe, frontal lobe, precentral gyrus, middle frontal gyrus, parietal lobe, superior frontal gyrus and paracentral lobule; the area under the AD model curve was 0.621, and the difference brain areas were cerebellar tonsil, cerebellar Stem, inferior frontal gyrus, midbrain, frontal lobe, precentral gyrus, postcentral gyrus, middle frontal gyrus and medial frontal gyrus; the area under the curve of the RD model was 0.625, and the difference brain regions were posterior cerebellum, midbrain, and middle frontal gyrus, precentral gyrus, frontal lobe, postcentral gyrus, superior frontal gyrus and medial frontal gyrus; the area under the curve of the FA + MD + AD + RD model was 0.739.
Conclusions
This study suggested that using diffusion tensor magnetic resonance imaging machine learning, it could distinguish between bulimia nervosa and healthy subjects and find neurobiological markers.
Fe 3 O 4 and bimetal–organic framework Zn/Mg composites peroxides- like catalyze luminol chemiluminescence for specific measurement of atropine in Datura plant
Authors: mahmoudi Shaida , chaichi Mohamad Javad , Shamsipur Mojtaba , Nazari Ome Leila , SamadiMaybodi Abdolrauf 
Published: October 2022

Abstract
Atropine(AT) is a tropane alkaloid used as an anticholinergic drug. This substance is abundantly found in Datura plant seeds. In this work, Zn/Mg bimetallic MOF was integrated with Fe3O4, and Fe3O4@Zn/Mg MOF(Fe3O4@MOF) composite was synthesized. This compound has a high peroxidase-like activity based on the chemiluminescence (CL) reaction. The synergistic effect of Zn, Fe, and Mg metals in the Fenton reaction causes the production of reactive oxygen species(ROS), resulting in high CL intensity. Addition of AT quenching CL and thus AT can be measured. The linear range and limit of detection(LOD) of this method for measuring AT standard solution are 3-600µgL− 1 and 10 − 4µgL− 1, respectively. This method is easy, fast, reversible, selective, without biodegradability effects, low cost, high accuracy, and precision for measuring AT in the Datura plant.
Parotid’s Intranodal palisaded myofibroblastoma: a very rare tumour: A case report
Authors: Rizkou Fatima Ezzahra , Rochdi Youssef , Oulghoul Omar , Benhoummad Othmane. , Raji Abdelaziz. 
Published: October 2022

Abstract
Background: intranodal palisaded myofibroblastoma is a rare benign tumor of the lymph nodes, arises from smooth muscle cells or myofibroblast almost always in the inguinal lymph nodes. There are no typical pathognomonic clinical and radiological features outlining multiple deferential diagnoses.
Case presentation: We, therefor report a rare case recurrent intranodal palisaded myofibroblastoma arising in the felt parotid gland in 53 year-old male patient, diagnosed by anatomopathological and immunopathological analysis.
Conclusion: described as benigntumor intranodal palisaded myofibroblastoma is scarce myofibroblastic neoplasm of the lymph nodes.Histological and immunopathological features are the determining factors of diagnostic of this favorable prognosis tumor.
Title Of the Article: Point of care gastric ultrasound to predict aspiration in patients undergoing urgent endotracheal intubation in the emergency medicine department.
Authors: Asokan Reshma , Bhardwaj Bharat Bhushan , Agrawal Naman , Chauhan Udit , Pillai Aadya , Shankar Takshak , Lalneiruol D. J , Baid Himanshi , Chawang Hannah , Patel Sanket Mukeshkumar 
Published: October 2022

Abstract
Background:
One significant cause of morbidity and mortality in patients undergoing endotracheal intubation is the aspiration of gastric contents. Its prevalence is more in the emergency than in elective settings. Point-of-care gastric ultrasound (GUS) is a non-invasive bedside ultrasonogram that provides both qualitative and quantitative information about the stomach contents. The diagnostic accuracy of GUS in terms of gastric parameters (measured antral diameters, antral cross-sectional area, and calculated gastric volume) to predict aspiration is yet unknown. We aim to determine this in the patients undergoing urgent emergency intubation (UEI) in the emergency department.
Methodology:
A prospective observational study was conducted at the emergency department of a tertiary healthcare center in India. Patients requiring UEI were identified and a bedside gastric ultrasound was done in the right lateral decubitus position using low frequency curved array probe. The qualitative data and the antral diameters (anteroposterior and craniocaudal) were assessed. The patient's clinical parameters and history regarding the last meal were noted. The cross-sectional area of gastric antrum was calculated using CSA = (AP×CC) π/4. The gastric volume is estimated using Perla's formula: GV = 27.0+14.6(RLD CSA) –1.28(age).
Results:
A hundred patients requiring urgent endotracheal intubation were enrolled in the study. Visible aspiration was more in participants with a distended gastric status (χ2=16.880, p=<0.001). The median gastric volume in the patients who aspirated was 146.37mL, and it ranged from 111.59mL-201.01mL. Using ROC analysis, a cut-off of CC diameter ≥2.35cm (sensitivity 88%, specificity 91%) and AP diameter ≥5.15cm (sensitivity 88%, specificity 87%) predicts aspiration. A calculated USG CSA cut-off ≥9.27cm² (sensitivity 100%, specificity 87%) and an USG gastric volume ≥111.594mL (sensitivity 100%, a specificity 92%) predicts aspiration.
Conclusion:
Point-of-care gastric ultrasound is an useful non-invasive bedside tool for risk stratification for aspiration in busy emergency rooms. We present threshold gastric antral parameters that can be used to predict aspiration along with its diagnostic accuracy. This can help the treating ED physician take adequate precautions, decide on intubation techniques and treatment modifications to aid in better patient management.
Hexavalent chromium causes centrosome amplification by inhibiting the binding between TMOD2 and NPM2
Authors: Zhao Meng Lu , Wang Jia Xin , Bian Xue Kai , Zhang Jun , Han Ya Wen , Xu Si Xian , Lee Shao Chin , Zhao Ji Zhong 
Published: October 2022

Abstract
Background

Hexavalent chromium can promote centrosome amplification (CA) as well as tumorigenesis. Since CA can lead to tumorigenesis, it is plausible that the chromium promotes the development of cancer via CA. In the present study, we investigated the signaling pathways of the chromium-induced CA.

Results

Our results showed that sub-toxic concentration of chromium was able to cause CA in HCT116 cells, and decreased the expression of TMOD2 and NPM2. Furthermore, TMOD2 and NPM2 interacted to each other via their C-terminal and the N-terminal, respectively, which was inhibited by the chromium. Overexpression of TMOD2 and NPM2 increased their binding and significantly attenuated the CA. Moreover, TMOD2 and NPM2 were co-localized with the centrosomes. The chromium inhibited the centrosomeal localization of NPM2, which is reversed by the overexpression of TMOD2, C-termianl of TMOD2, but not the N-terminal of NPM2.

Conclusion

Our results suggest that the chromium induces CA via inhibiting the binding between TMOD2 and NPM2, and the dissociation of NPM2 from centrosomes.
A bibliometric analysis to explore sentiment analysis in the domain of social media research
Authors: Dahish Zahra , Miah Shah J 
Published: October 2022

Abstract
Businesses use sentiment analysis in different ways for generating market or consumer insights to improve their performance. Existing sentiment analysis studies related to social media research have been significant due to the fact of their rapidly growing potential, as this type of analysis of social media content represents immense benefits. It is imperative to explore the need for such analysis to delineate the trend holistically for knowledge landscaping purposes. The study addresses the research gap through a comprehensive bibliometric review of 523 research articles published in the Scopus database (between 2018 and 2022) to discern the performance, content, and thematic analysis. We adopt an automated bibliometric study approach using the R-tool- biblioshiny for generating and presenting outcomes. Finding points on the vital usages of sentiment analysis such as innovation, transparency, and improved efficiency. It also highlights the uniqueness of sentiment analysis for synthesizing social media content to examine various aspects such as the knowledge-domain map that detects author collaboration networks as well as journal relationships.
Breast cancer prognostic signature associated with DNA damage response-related genes
Authors: Xu Jiali , Wang Long , Wang Jing , Yue Jian , Feng Rui , Wang Shuai , Zhang Xue , Li Hongzhong , Ren Guosheng , Cheng Qiao 
Published: October 2022

Abstract
Background
DNA damage response plays a key role in maintaining genomic integrity,which leads to breast cancer (BRCA). But the combined activities of numerous DNA damage response-related genes (DDR genes) are unknown.The purpose of this study was to ascertain the link between breast cancer prognosis and DDR genes.
Results
The data files were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). A prognostic risk score model including DDR genes was created utilizing LASSO and univariate Cox regression analysis.On the basis of DDR risk model,high-risk samples were found to meet a worse prognosis in the TCGA cohort as well as in the GEO cohort .According to the "pRRophetic" R package, low-risk samples were more sensitive to Doxorubicin and Bleomycin,while high-risk samples were more sensitive to Rapamycin. Given the correlations between prognostic risk scoring models, tumor microenvironment (TME) characteristics, and Tumor Immune Dysfunction and Exclusion (TIDE) outcomes, the high-risk group of the DDR risk model more sensitivity to immunotherapy,which leads to an instructional treatment for BRCA patients.
Conclusions
In this study,we found that DDR genes can be utilized as crucial factors to estimate prognosis in BRCA patients.
The Envelope Proteins from SARS-CoV-2 and SARS-CoV Potently Reduce the Infectivity of Human Immunodeficiency Virus type 1 (HIV-1)
Authors: Henke Wyatt , Waisner Hope , Arachchige Sachith Polpitiya , Kalamvoki Maria , Stephens Edward 
Published: October 2022

Abstract
Background: Viroporins are virally encoded ion channels involved in virus assembly and release. Human immunodeficiency virus type 1 (HIV-1) and influenza A virus encode for viroporins. The human coronavirus SARS-CoV-2 encodes for at least two viroporins, a small 75 amino acid transmembrane protein known as the envelope (E) protein and a larger 275 amino acid protein known as Orf3a. Here, we compared the replication of HIV-1 in the presence of four different β-coronavirus E proteins.
Results: We observed that the SARS-CoV-2 and SARS-CoV E proteins reduced the release of infectious HIV-1 yields by approximately 100-fold while MERS-CoV or HCoV-OC43 E proteins restricted HIV-1 infectivity to a lesser extent. Mechanistically, neither reverse transcription nor mRNA synthesis was involved in the restriction. We also show that all four E proteins caused phosphorylation of eIF2-α at similar levels and that lipidation of LC3-I could not account for the differences in restriction. However, the level of caspase 3 activity in transfected cells correlated with HIV-1 restriction in cells. Finally, we show that unlike the Vpu protein of HIV-1, the four E proteins did not significantly down-regulate bone marrow stromal cell antigen 2 (BST-2).
Conclusions: The results of this study indicate that while viroporins from homologous viruses can enhance virus release, we show that a viroporin from a heterologous virus can suppress HIV-1 protein synthesis and release of infectious virus.
Pingchuan formula and its separated recipes improve airway remodeling via regulation of the NLRP3/IL-1β axis in asthmatic mice
Authors: Xu Wanchao , Lu Zhenyu , Liu Xiao min , Wu Ruifeng , Cao Lan , Chen Lina , Chen Siyu , Zhuang Cheng , Yu Jianer 
Published: October 2022

Abstract
Objective
To investigate the role of Pingchuan formula (PCF) and its separated recipes (QYF and HTF) in ovalbumin (OVA)-induced asthmatic mouse model and explore its possible mechanisms.
Methods
A bronchial asthma mouse model was established using the ovalbumin excitation method. Distilled saline (for Sham group) and drugs (for DEX or PCF, QYF, HTF group) were administered by gavage immediately after the excitation. Mice were sacrificed after 61 days treatment. Lung tissue sections were stained with haemotoxylin and eosin and Masson's trichrome. The concentrations of interleukins (IL)-1β, -18, and TGF-β in bronchoalveolar lavage fluid (BALF) were determined by enzyme-linked immunosorbent assay. The expression of NLRP3 and caspase-1 was determined by immunohistochemistry, Western blot and Real-time PCR. Moreover, the levels of JNK, p-JNK, MMP-9, N-cadherin, E-cadherin, and T-NC were determined by Western blot.
Results
The asthma model was successfully established and the PCF, QYF, and HTF treatments effectively reduced lung tissue inflammation and deposition of airway collagen fibers. It was also observed that PCF significantly inhibited the release of IL-1β, -18, and TGF-β in BALF. Meanwhile, the expression of NLRP3, caspase-1, p-JNK, MMP-9, N-cadherin, and T-NC were markedly downregulated while E-cadherin was upregulated in the lung tissue of asthmatic mice.
Conclusions
These findings demonstrated that PCF and its separated recipes attenuate OVA‐induced pulmonary inflammation and promoted airway remodeling in mice via inhibiting NLRP3/IL-1β in asthma.
Sketching the Krylov Subspace: Faster Computation of the Entire Ridge Regularization Path
Authors: Wang Yifei , Pilanci Mert 
Published: October 2022

Abstract
We propose a fast algorithm for computing the entire ridge regression regularization path in nearly linear time. Our method constructs a basis on which the solution of ridge regression can be computed instantly for any value of the regularization parameter. Consequently, linear models can be tuned via cross-validation or other risk estimation strategies with substantially better efficiency. The algorithm is based on iteratively sketching the Krylov subspace with a binomial decomposition over the regularization path. We provide a convergence analysis with various sketching matrices and show that it improves the state-of-the-art computational complexity. We also provide a technique to adaptively estimate the sketching dimension. This algorithm works for both the over-determined and under-determined problems. We also provide an extension for matrix-valued ridge regression. The numerical results on real medium and large scale ridge regression tasks illustrate the effectiveness of the proposed method compared to standard baselines which require super-linear computational time.
Real-world data no the incidence of coronavirus disease (COVID-19) in patients with advanced thoracic cancer during the early phase of the pandemic in Japan
Authors: Fukuda Akito , Yoshida Tatsuya , Yagishita Shigehiro , Shiotsuka Mika , Kobayashi Osamu , Iwata Satoshi , Umeguchi Hitomi , Yanagida Maatoshi , Yasuhiro Irino , Masuda ken , Shinnno Yuki , Okuma Yusuke , Goto Yasushi , Horinouchi Hidehito , Hamada Akinobu , Yamamoto Noboru , Ohe Yuichiro 
Published: October 2022

Abstract
The severity and asscociated mortality of coronavirus disease 2019 (COVID-19) are higher in patients with thoracic cancer than in healthy populations and those with other cancer types. Here, we investigated real-world data on the incidence of COVID-19 and false-negative cases using severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) real-time reverse-transcription polymerase chain reaction (rRT-PCR) testing in patients with thoracic cancer. We retrospectively reviewed patients with advanced thoracic cancer at the National Cancer Center Hospital between March 2020–May 2021. Blood samples were collected and evaluated for IgM and IgG antibodies specific for nucleocapsid (N) and spike (S) protein SARS-CoV-2 before and after rRT-PCR testing. False-negative cases were assessed based on anti-SARS-CoV-2 antibody levels before and after rRT-PCR testing. A total of 2,107 patients with thoracic cancer were identified between March 2020 and May 2021, 7 (0.3%) of whom developed COVID-19. Among the 218 patients who underwent at least one rRT-PCR test because of suspected COVID-19 symptoms or as a screening test at our institute, the most common diagnosis was non-COVID-19 pneumonia (34.4%), followed by tumor fever (30.7%). Furthermore, of the 218 patients, 120 paired serum samples before and after rRT-PCR testing were available. Seroconversion was identified in all three patients with positive SARS-CoV-2 rRT-PCR results but was only observed in 1 out of the 117 patients who tested negative; the rate of false-negative cases was low (0.9%). COVID-19 incidence among patients with advanced thoracic cancer was low during the early phase of the pandemic in Japan.
Covid-19 pandemic: Impact and assessment of water quality in the lower Ganga riverine system, India
Authors: Bhor Manisha , Tiwari Nitish Kumar , Parida Pranaya Kumar , Das Basanta Kumar , Sarkar Uttam Kumar , Das Archan Kanti 
Published: October 2022

Abstract
The COVID-19 pandemic and its associated lockdown imposed all over India from 25th March 2020 to 14th April 2020 have made a significant impact on all sectors of life and livelihood including inland fisheries. However, the intensity and extent of the impact on inland open water resources especially rivers and associated water bodies is still unclear. In this study, an immediate and clear effect was observed in the quality of water flowing through the river Ganga. In consideration of pandemic conditions and difficulty in gathering field data, this study attempts to determine the river water quality in terms of turbidity, based on remote sensing imagery data. These changes have been recorded and analysed using Sentinel-2 multispectral remote sensing data for the lower stretches of river Ganga, for selected five stretches covering an approximate mid-channel length of 537 km. The highest sensitivity for turbidity was found in the red and NIR bands among all the bands which were used to estimate turbidity. Temporal variations were also studied through Normalized Difference Turbidity Index at each of these small stretches. A very steep decline in turbidity in the river water has been observed in each of the stretches. The study improved the understanding that the remote sensing approach is capable of assessing the water quality of river turbidity to a greater extent when there are strong hurdles to collecting research data from field studies.
For a Clinical Application of Optical Triangulation to Assess Respiratory Rate Using an RGB Camera and a Line Laser
Authors: Jeong Yoosoo , Song Chanho , Lee Hoyul , Park Young-Sang , Lee Seungmin , Jung Euisung , Son Jaebum 
Published: October 2022

Abstract
This paper presents a non-contact and unrestrained respiration monitoring system based on the optical triangulation technique. The proposed system consists of a red-green-blue (RGB) camera and a line laser installed to face the frontal thorax of a human body. The underlying idea of the work is that the camera and line laser are mounted in opposite directions, unlike other research. By applying the proposed image processing algorithm to the camera image, laser coordinates are extracted and converted to world coordinates using the optical triangulation method. These converted world coordinates represent the height of the thorax of a person. The respiratory rate is measured by analyzing changes of the thorax surface depth. To verify system performance, we installed the camera and the line laser on the head and foot sides of a bed, respectively, facing toward the center of the bed. Twenty healthy volunteers were enrolled and underwent meas-urement for 100s. Evaluation results show that the optical triangulation-based image processing method demonstrates non-inferior performance to a commercial patient monitoring system with a root-mean-squared error of 0.30rpm and a maximum error of 1rpm (p > 0.05), which implies the proposed non-contact system can be a useful alternative to the conventional healthcare method