bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of polypharmacy and potentially inappropriate medication use in older lung cancer patients: A systematic review and meta-analysis
Authors: Tian Fangyuan , Chen Zhaoyan , Zhou Dan , Mo Li 
Published: December 2022

Objectives: In older lung cancer patients, polypharmacy and the use of potentially inappropriate medications (PIMs) are commonly reported, but no systematic review or meta-analysis has been carried out to ascertain the prevalence and risk variables in this group. This study aimed to identify the prevalence of polypharmacy, PIMs and associated risk variables in older lung cancer patients.Methods: We searched for articles from the beginning to February 2022 in PubMed, Embase, and Web of Science that related the use of PIMs and polypharmacy by older lung cancer patients (PROSPERO Code No: CRD42022311603). Meta-analysis was performed on observational studies describing the prevalence and correlation of polypharmacy or PIMs in older patients with lung cancer.Results: Of the 387 citations, 6 articles involving 16,890 patients were included in the final sample. In older lung cancer patients pooled by meta-analysis, 38% and 35% of PIMs and polypharmacy, respectively. The prevalence of PIMs was 43%, 49%, and 28%, respectively, according to the 2019 AGS Beers criteria, 2014 screening tool for older people’s prescriptions/screening tool for alerting to the proper therapy (STOPP/START criteria) criteria, and other criteria.Conclusion: This systematic review and meta-analysis demonstrated a high prevalence of polypharmacy and PIMs among older lung cancer patients. Therefore, it is essential to take rational interventions for older lung cancer patients to receive reasonable pharmacotherapy.Systematic Review Registration: [https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42022311603].
Ameliorative effects of omega-lycotoxin-Gsp2671e purified from the spider venom of Lycosa praegrandis on memory deficits of glutamate-induced excitotoxicity rat model
Authors: Keimasi Mohammad , Salehifard Kowsar , Shahidi Marzieh , Esmaeili Fariba , Mirshah Jafar Esfahani Noushin , Beheshti Siamak , Amirsadri Mohammadreza , Naseri Faezeh , Keimasi Mohammadjavad , Ghorbani Najmeh , Mofid Mohammad Reza , Moradmand Majid 
Published: December 2022

Memory impairment is one of the main complications of Alzheimer’s disease (AD). This condition can be induced by hyper-stimulation of N-Methyl-D-aspartate receptors (NMDARs) of glutamate in the hippocampus, which ends up to pyramidal neurons determination. The release of neurotransmitters relies on voltage-gated calcium channels (VGCCs) such as P/Q-types. Omega-lycotoxin-Gsp2671e (OLG1e) is a P/Q-type VGCC modulator with high affinity and selectivity. This bio-active small protein was purified and identified from the Lycosa praegrandis venom. The effect of this state-dependent low molecular weight P/Q-type calcium modulator on rats was investigated via glutamate-induced excitotoxicity by N-Methyl-D-aspartate. Also, Electrophysiological amplitude of field excitatory postsynaptic potentials (fEPSPs) in the input–output and Long-term potentiation (LTP) curves were recorded in mossy fiber and the amount of synaptophysin (SYN), synaptosomal-associated protein, 25 kDa (SNAP-25), and synaptotagmin 1(SYT1) genes expression were measured using Real-time PCR technique for synaptic quantification. The outcomes of the current study suggest that OLG1e as a P/Q-type VGCC modulator has an ameliorative effect on excitotoxicity-induced memory defects and prevents the impairment of pyramidal neurons in the rat hippocampus.
Comparative antiseizure medications of adjunctive treatment for children with drug-resistant focal-onset seizures: A systematic review and network meta-analysis
Authors: Zhang Lanlan , Li Yuehong , Wang Weikai , Wang Chengzhong 
Published: December 2022

Purpose: In this study, we intended to compare and rank the efficacy and acceptability of antiseizure medications (ASMs) for adjunctive treatment of children with drug-resistant focal-onset seizures.Method: We conducted a computerized search of PubMed, EMBASE, Cochrane Library, Web of Science, and Google Scholar to identify eligible randomized controlled trials (RCTs) published before 31 May 2022. We included studies evaluating the efficacy and tolerability of antiseizure medications for children with drug-resistant focal-onset seizures. The efficacy and safety were reported in terms of responder and dropout rate along with serious adverse events, the outcomes were ranked with the surface under the cumulative ranking curve (SUCRA).Results: A total of 14 studies (16 trials) with 2,464 patients were included, involving 10 active antiseizure medications. For the primary endpoint of at least 50% reduction in focal-onset seizures, the surface under the cumulative ranking curve ranking suggested that lamotrigine and levetiracetam were more effective as compared with other antiseizure medications; moreover, levetiracetam had the highest probability of rank first for achieving seizure freedom. Concerning tolerability, oxcarbazepine and eslicarbazepine acetate were associated with higher dropout rates relative to other antiseizure medications and placebo, and topiramate was associated with higher occurrence of side effects. No significant differences were found between active antiseizure medications concerning dropout for side effects.Conclusion: According to the surface under the cumulative ranking curve ranking, lamotrigine, levetiracetam, and oxcarbazepine were more efficacious than other active antiseizure medications in terms of responder rate. Concerning tolerability, oxcarbazepine was more likely to lead to dropout and topiramate was associated with higher occurrence of side effects.
Effects of tannic acid supplementation on growth performance, gut health, and meat production and quality of broiler chickens raised in floor pens for 42 days
Authors: Choi Janghan , Liu Guanchen , Goo Doyun , Wang Jinquan , Bowker Brain , Zhuang Hong , Kim Woo Kyun 
Published: December 2022

A study was conducted to investigate the effects of tannic acid (TA) supplementation on growth performance, gut health, antioxidant capacity, gut microbiota, and meat yield and quality in broilers raised for 42 days. A total of 700 one-day-old male broiler chickens (Cobb500) were allocated into 5 treatments with 7 replicates of 20 birds per pen. There were five treatments: 1) tannic acid 0 (TA0: basal diet without TA); 2) tannic acid 0.25 (TA0.25: basal diet+0.25 g/kg TA); 3) tannic acid 0.5 (TA0.5: basal diet+0.5 g/kg TA); 4) tannic acid 1 (TA1: basal diet+1 g/kg TA); and 5) tannic acid 2 (TA2: basal diet+2 g/kg TA). The dietary phases included starter (D 0 to 18; crumble feed), grower (D 18 to 28; pellet feed), and finisher (D 28 to 42; pellet feed). On D 18, the supplementation of TA linearly reduced body weight (BW) and average daily feed intake (ADFI) (p &lt; 0.05), and on D 28, the supplementation of TA linearly reduced BW, average daily gain (ADG), and feed conversion ratio (FCR) (p &lt; 0.05). Relative mRNA expression of genes related to mucin production (MUC2), tight junction proteins (CLDN2 and JAM2), and nutrient transporters (B0AT1 and SGLT1) was linearly increased by the supplementation of TA (p &lt; 0.05). The supplementation of TA tended to linearly increase the relative abundance of the family Enterobacteriaceae (p = 0.08) and quadratically increased the relative abundance of the families Lachnospiraceae and Ruminococcaceae in the cecal microbial communities (p &lt; 0.05). On D 36, the ratio of the phyla Firmicutes and Bacteroidetes was quadratically reduced by the supplementation of TA (p &lt; 0.05). On D 42, bone mineral density and the lean to fat ratio were linearly decreased by the supplementation of TA (p &lt; 0.05). On D 43, total chilled carcass weight was linearly reduced (p &lt; 0.05), and proportion of leg weight was increased by supplementation of TA (p &lt; 0.05). The supplementation of TA linearly reduced pH of the breast meat (p &lt; 0.05) and linearly increased redness (a*) (p &lt; 0.05). Although the supplementation of TA positively influenced gut health and gut microbiota in the starter/grower phases, it negatively affected overall growth performance, bone health, and meat production in broilers on D 42.
Storage temperature dictates the ability of chicken embryos to successfully resume development by regulating expression of blastulation and gastrulation genes
Authors: Pokhrel Narayan , Genin Olga , Sela-Donenfeld Dalit , Cinnamon Yuval 
Published: December 2022

The avian embryo has a remarkable ability that allows it to suspend its development during blastulation for a long time at low temperatures, and to resume normal development when incubated. This ability is used by poultry hatcheries to store eggs prior to incubation. We have previously found that this ability correlates with the temperature during storage; embryos recover much better following prolonged storage at 12°C rather than at 18°C. However, the molecular and cellular mechanisms underlying these differences are poorly understood. To successfully resume development following storage, the embryo has to shift from the blastulation phase to gastrulation. Several genes are known to partake in the blastulation-to-gastrulation transition under normal conditions, such as the pluripotency-related genes Inhibitor of DNA Binding 2 (ID2) and NANOG that are expressed during blastulation, and the gastrulation-regulating genes NODAL and Brachyury (TBXT). However, their expression and activity following storage is unknown. To elucidate the molecular mechanisms that initiate the ability to successfully transit from blastulation to gastrulation following storage, embryos were stored for 28 days at 12°C or 18°C, and were assessed either prior to incubation, 12, or 18 h of incubation at 37.8°C. Immediately following storage at 18°C group showed remarkable impaired morphology compared to the blastoderm of the 12°C group and of non-stored control embryos. Concurrently with these, expression of ID2 and NANOG was maintained following storage at 12°C similar to the control group, but was significantly reduced upon storage at 18°C. Nevertheless, when the 18°C-stored embryos were incubated, the morphology and the reduced genes were reverted to resemble those of the 12°C group. At variance, key gastrulation genes, NODAL and its downstream effector Brachyury (TBXT), which were similarly expressed in the control and the 12°C group, were not restored in the 18°C embryos following incubation. Notably, ectopic administration of Activin rescued NODAL and TBXT expression in the 18°C group, indicating that these embryos maintain the potential to initiate. Collectively, this study suggests a temperature-dependent mechanisms that direct the transition from blastulation to gastrulation. These mechanisms promote a successful developmental resumption following prolonged storage at low temperatures.
Environmental drivers of the leaf nitrogen and phosphorus stoichiometry characteristics of critically endangered Acer catalpifolium
Authors: Zhang Yuyang , Cheng Xiaoyu , Sha Zhipeng , Lekammudiyanse Manuja U. , Ma Wenbao , Dayananda Buddhi , Li Shuang , Lyu Ruiheng 
Published: December 2022

Acer catalpifolium is a perennial deciduous broad-leaved woody plant, listed in the second-class protection program in China mainly distributed on the northwest edge of Chengdu plain. However, extensive anthropogenic disturbances and pollutants emissions (such as SO2, NH3 and NOX) in this area have created a heterogeneous habitat for this species and its impacts have not been systematically studied. In this study, we investigated the leaf nitrogen (N) and phosphorus (P) content of A. catalpifolium in the natural distribution areas, and a series of simulation experiments (e.g., various water and light supply regimes, different acid and N deposition levels, reintroduction management) were conducted to analyze responses of N and P stoichiometric characteristics to environmental changes. The results showed that leaf nitrogen content (LNC) was 14.49 ~ 25.44 mg g-1, leaf phosphorus content (LPC) was 1.29~3.81 mg g-1 and the N/P ratio of the leaf (L-N/P) was 4.87~13.93. As per the simulation experiments, LNC of A. catalpifolium is found to be relatively high at strong light conditions (80% of full light), high N deposition (100 and 150 kg N ha-1), low acidity rainwater, reintroduction to understory area or N fertilizer applications. A high level of LPC was found when applied with 80% of full light and moderate N deposition (100 kg N ha-1). L-N/P was high under severe shade (8% of full light), severe N deposition (200 kg N ha-1), and reintroduction to gap and undergrowth habitat; however, low L-N/P was observed at low acidity rainwater or P fertilizer application. The nutrient supply facilitates corresponding elements uptake, shade tends to induce P limitation and soil acidification shows N limitation. Our results provide theoretical guidance for field management and nutrient supply regimes for future protection, population rejuvenation of this species and provide guidelines for conservation and nutrient management strategies for the endangered species.
Employability in the public sector: The impact of individual and organizational determinants
Authors: Vermeeren Brenda , Van der Heijden Beatrice 
Published: December 2022

IntroductionThe importance of employability within organizations is increasing, due to various developments that initiate organizational changes. This study focuses on the employability in the public sector. While there seems to be a clear need for an employable public sector workforce, up until now there is little empirical research into the employability of workers in this sector, and into which specific individual and organizational characteristics influence it.MethodsWe conducted structural equation modeling, using data from Dutch public sector employees (n= 13.471).ResultsOur outcomes show that public sector employees consider themselves to be reasonably employable internally, and that they rate their external employability slightly higher. Moreover, it was found that both individual (personality and risk-taking behavior) and organizational characteristics (transformational leadership and red tape) influence their employability.DiscussionThese results underline the dual responsibility of the employee and the organization in influencing workers’ employability within the public sector.
Analysis of the mental health service provision in Qatar: Progressing in community mental health in a Middle East country
Authors: Salinas-Perez Jose A. , Ghuloum Suhaila , Gutierrez-Colosia Mencia R. , Bagheri Nasser , Salvador-Carulla Luis 
Published: December 2022

BackgroundQatari health planning in the last decade aimed to make the transition from the traditional hospital-based psychiatric care to a community-based care, building an integrated and comprehensive mental health system. The objective of this study was to explore the mental health service provision in Qatar in 2018 and 2022. This time span coincided with two mental health plans (2013–2018 and 2019–2022) and one health plan (2018–2022).MethodsThis study followed a healthcare ecosystem approach, including context analysis and the standard description and classification of mental health services. Service provision was studied applying DESDE-LTC system (Description and Evaluation of Services and DirectoriEs–Long Term Care), an internationally validated methodology to assess and describe mental health services. Service data were analyzed along with sociodemographic indicators from public statistics to know the care context.ResultsThe availability of specialized mental health services increased for adults, although it remained the same for other age groups. The diversity of care and the weight of health-related care over social-related care also remained quite similar. It was noteworthy the development of new services for young adults, migrant workers, and female populations.ConclusionThis was the first time that this service research methodology has been applied in a Middle East country to study its mental healthcare pattern. The analysis of the mental healthcare pattern in the study time period showed the continued progress toward community-based care in Qatar in the framework of three health plans and despite the unexpected COVID-19 world pandemic.
Economic Migrants and Clinical Course of SARS-CoV-2 Infection: A Follow-Up Study
Authors: Martínez-Alfonso Julia , Mesas Arthur Eumann , Jimenez-Olivas Nuria , Cabrera-Majada Antonio , Martínez-Vizcaíno Vicente , Díaz-Olalla José Manuel 
Published: December 2022

Objective: To analyze whether social deprivation and economic migrant (EM) status influence the risk of being hospitalized with COVID-19.Methods: This was a retrospective follow-up study including all patients older than 18 years attending the Daroca Health Center in Madrid, Spain, diagnosed with COVID-19 during September 2020. Data on EM status and other sociodemographic, lifestyle and comorbidities that could affect the clinical course of the infection were obtained from electronic medical records.Results: Of the 796 patients positive for COVID-19, 44 (5.53%) were hospitalized. No significant differences were observed between those who were hospitalized and those who were not in the mean of social deprivation index or socioeconomic status, but EM status was associated with the risk of being hospitalized (p = 0.028). Logistic regression models showed that years of age (OR = 1.07; 95% CI: 1.04–1.10), EM status (OR = 5.72; 95% CI: 2.56–12.63) and hypertension (OR = 2.22; 95% CI: 1.01–4.85) were the only predictors of hospitalization.Conclusion: Our data support that EM status, rather than economic deprivation, is the socioeconomic factor associated with the probability of hospital admission for COVID-19 in Madrid, Spain.
A New Species of the Genus Robertgurneya Apostolov & Marinov, 1988 (Copepoda: Harpacticoida: Miraciidae) from a Sublittoral Zone of Jeju Island, Korea
Authors: Yeom Jisu , Lee Wonchoel 
Published: December 2022

A new species, Robertgurneya jejuensis sp. nov., was described from sandy sediment samples collected at a depth of 25 m on Mun Island, Jeju, in June 2018. The new species is morphologically similar to Robertgurneya similis similis (Scott A., 1896) and Robertgurneya donghaensis Bang, 2021; this is the second record of the genus Robertgurneya in South Korea. The morphological characteristics of the similis group within the genus Robertgurneya, to which the new species is ascribed, are summarized here. Furthermore, an identification key is provided based on the summary. Molecular identification of the collected specimens, based on the nuclear 18S ribosomal RNA (18S rRNA) and the mitochondrial cytochrome oxidase subunit I fragment, was obtained. Finally, a phylogenetic tree was constructed to present the position of Robertgurneya within the Miraciidae family based on 18S rRNA sequences which is relatively conserved. As a result, the relationship with sister genera morphologically similar to Robertgurneya was also molecularly confirmed.
L'émergence des supporters « ultras » en France
Authors: Hourcade Nicolas 
Published: December 2022

Les comportements des supporters de football et le sens qu'ils accordent à cette activité ont fortement évolué depuis les années 1960. Des supporters radicaux sont alors apparus, d'abord en Angleterre et en Italie, puis dans le reste de l'Europe. Pour ces fans extrêmes, le supportérisme constitue un enjeu en soi : ils se conçoivent comme des acteurs et non comme de simples spectateurs.
En France, le modèle italien des ultras s'est particulièrement développé. Ces ultras se structurent en associations et organisent, de manière intense et spectaculaire, le soutien à leur équipe. La compétition entre groupes n'est pas seulement symbolique (via les chants ou les animations) : il leur arrive de s'affronter violemment. Leur attitude s'avère ambivalente : ils cherchent une reconnaissance sociale mais entendent demeurer rebelles.
Cette pratique offre aux jeunes hommes issus de milieux sociaux variés qui s'y engagent des activités de loisirs, une vie de groupe, l'opportunité d'acquérir une identité personnelle et une cause à défendre. Elle constitue ainsi un moyen de réaliser l'impératif moderne d'être soi, d'être l'acteur de sa propre vie. Elle s'inscrit également dans le contexte général d'émergence de la jeunesse comme classe d'âge.
Protestantisme et utopie en France aux XVIe et XVIIe siècles
Authors: Yardeni Myriam 
Published: December 2022

Calvinism and Utopia in the 16th and 17th Century
Since its first appearance, Calvinism has been doomed to remain a minority phenomenon in France, so that the Huguenots had to develop a minority mentality. This mentality finds one of its best expressions in the utopias and the utopianism. It's not a coincidence if the first French utopia, Antangil (1616), an anonymous work, is a Huguenot utopia, nor that six of the eight most important utopias or utopian descriptions of the Louis XIV time are Huguenot or converted Catholics works. Antangil is a nostalgic and «monarchomatical» utopia, still deeply rooted in the French soil. The Grand Dessein of Sully is an international and European utopia. The Louis XIV time utopias, for their part, are marked by the acceptance of the diaspora status and also by the mental and geographical disorientation which follows its exile and growing distance to France and also to God. One only utopia, L'île d'Eden, from Henri Duquesne, still remains in many ways a true French Huguenot utopia.
La sainteté de Jérusalem : instrument géopolitique
Authors: Encel Frédéric 
Published: December 2022

La sainteté de Jérusalem : instrument géopolitique.
Jérusalem, ville sainte pour les trois monothéismes, à des degrés divers, est aujourd'hui revendiquée pour capitale par deux nations concurrentes, palestinienne et israélienne. Pourtant, la ville n'a pas toujours occupé une place aussi centrale, si l'on se réfère aux textes coranique et biblique. Les premiers musulmans ne souffrent pas de la voir tomber entre des mains infidèles, mais, une fois que sa possession leur est acquise, ne lui accordent que peu d'attention : c'est l'intérêt des sionistes pour Jérusalem qui devait susciter en retour celui du nationalisme palestinien. Dans le Coran, la ville ne figure pas explicitement ; dans la Bible, par ailleurs, on est surpris de découvrir que Jérusalem, la cité des Jésusites, n'est conquise que tardivement par les Israélites, et que le récit de son destin paradoxal est peut-être une pièce destinée à grandir David et sa tribu de Juda, face à son adversaire le roi Saül. Autant de ruses de l’histoire, en l'occurrence des textes religieux, plus ouverts, plus incertains que les reconstructions nationalistes contemporaines
Langue et diasporas. Trois exemples d'expansion paradoxale du français
Authors: Cabanel Patrick 
Published: December 2022

Lengua y diasporas : tres ejempbs de la expansión paradójica del idioma francés.
La historia del esplendor internacional de la lengua francesa no está ligada unicamente al prestigio de sus literatos oala expansion del império colonial : en tres ocasiones porlo menos, el francés ha sido diseminado y apropiado por las diasporas. Los protestantes del Refugio Huguenote después de 1685 y los miembros de las congregaciones religiosas, a principios del Siglo XX, han preferido darle la espalda a una Francia que negaba sus derechos pero han seguido utilizando la lengua a la cual le han conferido un destino, europeo y medio oriental, brillante. Tambien en esa época, los judios de la diaspora sefarade mediterranea adoptaron el francés propuesto por la Alianza Universal Israelita y enviaron sus élites a Paris. Son très ejemplos de una di fusion paradôjica : la proyecciôn de una lengua es consecuencia de una desgracia anti¬ gua o reciente padecida por el que la habla. Es posible que el destino de otras lenguas haya incorporado este axioma dulce-amargo. Algu-nos elementos de reflexion son propuestos con respecto a la lengua alemana y los judios.