bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological features and prognostic impact of dirty necrosis in metastatic lung cancers from the colon and rectum
Authors: Konishi Yasuhito , Taki Tetsuro , Nakai Tokiko , Kuroe Takashi , Morisue Ryo , Miyoshi Tomohiro , Tane Kenta , Samejima Joji , Aokage Keiju , Miyazaki Saori , Sakamoto Naoya , Sakashita Shingo , Watanabe Reiko , Kojima Motohiro , Suzuki Kenji , Tsuboi Masahiro , Ishii Genichiro 
Published: November 2022

AbstractDirty necrosis (DN) is a form of tumor necrosis (TN) with prominent neutrophil infiltration and cell detritus in the necrotic foci. This study aimed to characterize the clinicopathological features of DN in metastatic lung cancers of the colon and rectum (MLCRs). A total of 227 patients who underwent pulmonary metastasectomy and complete resection for MLCR were included in this study. TN was evaluated using digitally scanned resection specimens. These slides were immunostained for biomarkers of NETosis (citrullinated histone H3 [citH3] and myeloperoxidase [MPO]), and the area positive for citH3 and MPO was further quantified. TN was observed in 216 cases (95.2%), and 54 (25.0%) of these cases had DN. The presence of TN was not associated with a worse prognosis; however, patients with DN had a significantly shorter overall survival than those without DN (p < 0.01). Furthermore, the presence of DN was a poor prognostic factor in both the univariate and multivariate analyses. Immunohistochemical analysis revealed that the percentage of citH3‐positive and MPO‐positive areas in the DN‐positive cases was significantly higher than that in the DN‐negative cases (p < 0.01 and p < 0.01, respectively). In surgically resected MLCR, DN is the characteristic TN subtype associated with poor prognosis and neutrophil extracellular traps (NETs).
Shikonin reverses pyruvate kinase isoform M2‐mediated propranolol resistance in infantile hemangioma through reactive oxygen species‐induced autophagic dysfunction
Authors: Yang Enli , Wang Xuan , Huang Shengyun , Li Mingyang , Li Yiming , Geng Yiming , Liu Xuejian , Chen Zhanwei , Zhang Dongsheng , Wu Haiwei 
Published: November 2022

AbstractInfantile hemangioma (IH) is the most common benign tumor in infancy. Propranolol, a nonselective β‐adrenergic receptor blocker, is now the first‐line therapy for IH. Recently, low sensitivity to propranolol therapy has become one major reason for the failure of IH treatment. However, the exact underlying mechanisms are yet to be fully elucidated. Here, we reported that pyruvate kinase isoform M2 (PKM2), an essential glycolytic enzyme, played a critical role in regulating the progression of IH and the therapeutic resistance of propranolol treatment. Shikonin reversed the propranolol resistance in hemangioma‐derived endothelial cells and in hemangioma animal models. Moreover, shikonin combined with propranolol could induce excessive reactive oxygen species (ROS) accumulation and lead to autophagic dysfunction, which is essential for the enhanced therapeutic sensitivity of propranolol treatment. Taken together, our results indicated that PKM2 has a significant role in hemangiomas progression and therapeutic resistance; it could be a safe and effective therapeutic strategy for those hemangiomas with poor propranolol sensitivity combined with shikonin.
Clinical, radiographic, and esthetic evaluation of immediate implant placement with buccal bone dehiscence in the anterior maxilla: A 1‐year prospective case series
Authors: Qian Shu‐Jiao , Pu Yi‐ping , Zhang Xiao‐Meng , Wu Xin‐yu , Liu Bei‐lei , Lai Hong‐Chang , Shi Jun‐Yu 
Published: November 2022

AbstractObjectivesTo evaluate the clinical, radiographic, and esthetic outcomes of immediate implant placement with buccal bone dehiscence in the anterior maxilla.MethodsIn this case series, implants were inserted immediately after tooth extraction in sockets with buccal bone dehiscence. Guided bone regeneration (GBR) with a papilla preservation flap and simultaneous connective tissue grafting (CTG) was used. The following outcome variables were measured: mid‐facial mucosal recession, probing depth, bleeding on probing, Pink Esthetic Score (PES), marginal bone loss, and thickness of buccal bone plate (TBP).Results12 patients were recruited. Stable mid‐facial mucosal level (−0.03 ± 0.17 mm) and excellent soft‐tissue esthetic outcomes (PES, 9.17 ± 0.72) were achieved at 1 year. The TBP at platform level was 2.01 ± 0.31 mm at 1‐year follow up with a resorption rate of 28.90% ± 15.14%.ConclusionsImmediate implant placement using GBR performed with a papilla preservation approach and simultaneous CTG is a feasible treatment procedure in compromised extraction sockets in the anterior region. Favorable esthetic outcomes and buccal bone thickness were obtained. Further studies were needed to evaluate the long‐term tissue alteration.
The early Christian origins of voluntary poor relief
Authors: Koehler Benedikt 
Published: November 2022

AbstractPoor relief funded by voluntary contributions originated in early Christianity. Roman paganism did not practise poor relief; post‐exilic Judaism practised poor relief funded by mandatory contributions; early Christianity introduced poor relief on a voluntary basis. Jesus, Peter, and Paul were formative for early Christian poor relief. Jesus set examples of dispensing alms and respecting private property. Peter and Paul agreed on the duty to fund poor relief but did not agree whether funding of poor relief was mandatory or voluntary. The variant approaches of Peter and Paul to how to reconcile poor relief with property rights opened a fault line that has persisted throughout Christian history.
Comparison of outcomes between Hodgkin's lymphoma patients treated in and outside clinical trials: A study based on theEORTC‐Dutchlate effects cohort‐linked data
Authors: Juul Sidsel Jacobsen , Kicinski Michal , Schaapveld Michael , Rossetti Sára , Aleman Berthe M. P. , Liu Lifang , van Leeuwen Flora E. , Meijnders Paul , Krol Augustinus D. G. , Janus Cécile P. M. , Hutchings Martin , Maraldo Maja V. 
Published: November 2022

AbstractStudies have shown higher survival rates for patients with Hodgkin lymphoma (HL) treated within clinical trials compared to patients treated outside clinical trials. However, endpoints are often limited to overall survival (OS). In this retrospective cohort study, we investigated the effect of trial participation on OS, the incidence of relapse, second cancer, and cardiovascular disease (CVD). The study population consisted of patients with HL, aged between 14 and 51 years at diagnosis, who started their treatment between 1962 and 2002 at three Dutch cancer centres. Patients were either included in the EORTC Lymphoma Group trials (H1–H9) or treated according to standard guidelines at the time. After adjusting for differences in baseline characteristics, trial participation was associated with longer OS (median OS: 29.4 years [95%CI: 27.0–31.6] for treatment inside trials versus 27.4 years [95%CI: 26.0–28.5] for treatment outside trials,p = .046), a lower incidence of relapse (HR = 0.79, 95%CI: 0.63–0.98,p = .036) and a higher incidence of CVD (HR = 1.49, 95%CI: 1.23–1.79,p < .001). The trial effect for CVD was present only for patients treated before 1983. No evidence of differences in the incidence of second cancer was found. Consequently, essential results from clinical trials should be implemented into standard practice without undue delay.
Disruption of the anterior commissure in Olig2 deficient mice
Authors: Gotoh Hitoshi , Maruyama Kohei , Yoshii Kengo , Yamauchi Nao , Nomura Tadashi , Ohtsuka Satoshi , Shirasaki Ryuichi , Takebayashi Hirohide , Ono Katsuhiko 
Published: November 2022

AbstractIn the present study, we examined neural circuit formation in the forebrain of the Olig2 knockout (Olig2‐KO) mouse model and found disruption of the anterior commissure at the late foetal stage. Axon bundles of the anterior commissure encountered the wall of the third ventricle and ceased axonal extension. L1‐CAM immunohistochemistry showed that Olig2‐KO mice lose decussation formation in the basal forebrain. DiI tracing revealed that the thin bundles of the anterior commissure axons crossed the midline but ceased further extension into the deep part of the contralateral side. Furthermore, some fractions of DiI‐labelled axons were oriented dorsolaterally, which was not observed in the control mouse forebrain. The rostral part of the third ventricle was much wider in the Olig2‐KO mice than in wild‐type mice, which likely resulted in the delay of midline fusion and subsequent delay and malformation of the anterior commissure. We analysed gene expression alterations in the Olig2‐KO mice using a public database and found multiple genes, which are related to axon guidance and epithelial‐mesenchymal transition, showing subtle expression changes. These results suggest that Olig2 is essential for anterior commissure formation, likely by regulating multiple biological processes.
Public sector accounting harmonization in the European Union through the lens of the garbage can model
Authors: Cohen Sandra , Manes Rossi Francesca , Brusca Isabel 
Published: November 2022

AbstractThe public sector accounting harmonization process that started in the European Union in the aftermath of the financial crisis led the European Commission to launch a project for the development of a set of European Public Sector Accounting Standards (EPSAS). This paper analyses the process and the decision‐making around development of the EPSAS through the lens of thegarbage can model(Cohen, M. D., March, J. G., & Olsen, J. P. (1972). A garbage can model of organizational choice.Administrative Science Quarterly,17(1), 1–25). More specifically, by identifyingproblems,participants,solutions, andchoice opportunities, it discusses why the development of the EPSAS is taking so long and why the process does not seem to be progressing as planned. To this end, documents related to the process of EPSAS development are analyzed. The results provide evidence of problematic preferences and fluid participation possibly coupled with flight decisions—three elements of the garbage can model. Postponing decisions can be an option to dampen reluctance. The more the public sector becomes accustomed to the International Public Sector Accounting Standards (IPSAS) by adopting IPSAS‐like accrual accounting standards while waiting for the completion of the EPSAS, the less resistance there might be to moving to accrual accounting standards. However, at the same time, an imminent change to a new set of EPSAS standards might become less plausible if changes demand extra reform.
Effect of rafted microstructure and its temperature dependency on fatigue crack propagation in a single‐crystal Ni‐base superalloy
Authors: Sakaguchi Motoki , Okamoto Ryota , Karato Takanori , Suzuki Kenta 
Published: November 2022

AbstractEffects of rafted microstructure and its temperature dependency on fatigue crack propagation (FCP) in a single‐crystal Ni‐base superalloy are experimentally investigated. FCP tests are conducted at room temperature, 450°C, and 700°C for two types of pre‐rafted specimens, and their FCP behaviors are compared with that of a specimen with cuboidal γ′ precipitates. It is found in the experiments that there is no significant influence of rafted microstructures on FCP rate at room temperature, while a clear influence is pronounced at 450 and 700°C depending on the coarsening direction of rafted microstructures and the level of stress intensity factor range. The temperature dependency in the effect of rafted microstructure is discussed with special considerations on the microscopic FCP behavior affected by the morphology of γ′ precipitates, the coherency of the γ/γ′ interface, and temperature‐dependent slip characteristics of γ and γ′ phases.
Integrated Performance Assessment (IPA): Implementation, task types, and feedback
Authors: Sedor Nicole 
Published: November 2022

AbstractThis longitudinal, multi‐semester study investigates the Integrated Performance Assessment (IPA) in university‐level communicative Spanish classrooms to find out how instructor feedback affects student performance on IPA assessments, if at all, and in what ways do teachers and students use feedback from the IPAs in their teaching and learning, if at all, to navigate the relationship of assessment and feedback within the IPA framework. A mixed‐methods analysis of the effect of instructor (n = 7) feedback on student (n = 103) progress in the performance of oral and written communication revealed that corrective feedback benefitted learners on interpretive and presentational tasks, but hindered their progress on interpersonal tasks. The findings suggest that instructors should provide feedback in a modality that corresponds with the task type.
Planktonic functional diversity changes in synchrony with lake ecosystem state
Authors: O'Brien Duncan A. , Gal Gideon , Thackeray Stephen J. , Matsuzaki Shin‐ichiro S. , Clements Christopher F. 
Published: November 2022

AbstractManaging ecosystems to effectively preserve function and services requires reliable tools that can infer changes in the stability and dynamics of a system. Conceptually, functional diversity (FD) appears as a sensitive and viable monitoring metric stemming from suggestions that FD is a universally important measure of biodiversity and has a mechanistic influence on ecological processes. It is however unclear whether changes in FD consistently occur prior to state responses or vice versa, with no current work on the temporal relationship between FD and state to support a transition towards trait‐based indicators. There is consequently a knowledge gap regarding when functioning changes relative to biodiversity change and where FD change falls in that sequence. We therefore examine the lagged relationship between planktonic FD and abundance‐based metrics of system state (e.g. biomass) across five highly monitored lake communities using both correlation and cutting edge non‐linear empirical dynamic modelling approaches. Overall, phytoplankton and zooplankton FD display synchrony with lake state but each lake is idiosyncratic in the strength of relationship. It is therefore unlikely that changes in plankton FD are identifiable before changes in more easily collected abundance metrics. These results highlight the power of empirical dynamic modelling in disentangling time lagged relationships in complex multivariate ecosystems, but suggest that FD cannot be generically viable as an early indicator. Individual lakes therefore require consideration of their specific context and any interpretation of FD across systems requires caution. However, FD still retains value as an alternative state measure or a trait representation of biodiversity when considered at the system level.
Earthquake, disaster capitalism and massive urban transformation in Istanbul
Authors: Güney K. Murat 
Published: November 2022

AbstractIn this paper, I discuss how the earthquake risk is exploited by ‘disaster capitalism’, in order to convert Istanbul to a massive construction site. The shock of the 1999 Marmara Earthquake has been effectively used by the neoliberal market and government as ‘a shock therapy’ to implement a construction‐led development model for Turkey and to favour the construction sector by introducing new incentives, exceptional rights and interventions, which otherwise might be challenged. The current Turkish government justify the ongoing massive urban transformation and new mass housing projects as an improvement of the housing stock to make residential buildings stronger and more resilient to earthquakes. However, areas actually under earthquake risk do not match the areas that are officially declared under disaster risk by the government. The Disaster Law #6306 that granted the government the absolute right to expropriate land based on the justification of ‘protecting residents against earthquakes and other natural disasters’ was applied in a selective way to seize valuable land in Istanbul. In the paper I explore how the disaster was quickly converted to an opportunity for economic growth. To do that I introduce stories of three different neighbourhoods in Istanbul, namely Moda, Tozkoparan and Fikirtepe, each of which experience the ongoing massive urban transformation differently based on the land value of the neighbourhoods, class position of the residents, and residents' capacity to organise in order to protect their rights. I describe, how disaster capitalism is lived and experienced differently in these three neighbourhoods. Although the massive construction projects are indifferent to life's sustainability, those projects are justified as interventions in terms of public health and safety through making housing resilient to earthquakes. I critically discuss how in each case biopolitics presents disaster capitalism's massive urban transformation projects as a manifestation of liveliness.
Refractory glossopharyngeal neuralgia successfully treated with onabotulinumtoxinA: A case report
Authors: Hamilton Katherine T. , Seligman Rachel , Blue Rachel , Lee John Y. K. 
Published: November 2022

AbstractBackgroundGlossopharyngeal neuralgia is a rare but severe and disabling pain condition often caused by vascular compression of the glossopharyngeal nerve. Treatment is similar to that of trigeminal neuralgia, but some patients may be refractory to both medical and surgical approaches. Here we present a case of refractory glossopharyngeal neuralgia that responded well to onabotulinumtoxinA (BTX‐A).CaseWe report a case of a 65‐year‐old man with well‐controlled human immunodeficiency virus disease with glossopharyngeal neuralgia symptoms since 2015. He had partial response to medications but was limited by side‐effects. He underwent microvascular decompression twice with initial relief both times, but experienced recurrence of attacks 1–3 years after each surgery. He was treated with BTX‐A using the chronic migraine PREEMPT protocol (i.e., 31–39 injection sites in head and neck muscles), which led to significant relief of his glossopharyngeal neuralgia pain.ConclusionsThis is the first case to our knowledge of glossopharyngeal neuralgia treated with BTX‐A. BTX‐A can be an effective treatment for glossopharyngeal neuralgia, even when injections are not administered directly over the sensory distribution of the glossopharyngeal nerve.
Early diagnosis of hepatic inflammation in Japanese nonalcoholic fatty liver disease patients using 3D MR elastography
Authors: Komiyama Yasuyuki , Motosugi Utaroh , Maekawa Shinya , Osawa Leona , Nakakuki Natsuko , Takada Hitomi , Muraoka Masaru , Suzuki Yuichiro , Sato Mitsuaki , Takano Shinichi , Fukasawa Mitsuharu , Yamaguchi Tatsuya , Onishi Hiroshi , Yin Meng , Enomoto Nobuyuki 
Published: November 2022

AbstractBackgroundThe damping ratio (DR) and the loss modulus (G″) obtained by 3D MR elastography complex modulus analysis has been reported recently to reflect early intrahepatic inflammation, and is expected to be a noninvasive biomarker of inflammation in nonalcoholic fatty liver disease (NAFLD). However, the role of the DR and the G″ in Japanese NAFLD patients remains unclear.MethodsWe enrolled 39 Japanese patients with NAFLD who underwent liver biopsy and 3D MR elastography within 1 month and analyzed the association between DR, G″, and histological activity.ResultsRegarding DR, no evident correlation was observed between the DR and histological activity (p = 0.14) when patients with all fibrosis stages were included. However, when patients were restricted up to stage F2 fibrosis, the association of the DR and inflammation became significant, the DR increasing with the degree of activity (p = 0.02). Among the constituents of fibrosis activity, ballooning correlated with the DR (p < 0.01) while lobular inflammation did not. Regarding G″, it was correlated with histological activity (p < 0.01), ballooning (p < 0.01), and lobular inflammation (p < 0.01) in patients with all fibrosis stages and in patients up to F2 fibrosis (p = 0.03 for activity and p = 0.04 for ballooning). The best cutoff value of DR for hepatitis activity in patients within the F2 stage was 0.094 (area under the receiver operating characteristic curve 0.775, 95% CI: 0.529–1.000) and G″ was 0.402 (area under the receiver operating characteristic curve 0.825, 95% CI: 0.628–1.000).ConclusionsThe DR and G″ reflected the histological activity in Japanese patients with NAFLD during the early stage, indicating these values for noninvasive diagnosis of inflammation in Japanese patients with NAFLD.
Delayed HIV diagnosis during the COVID‐19 pandemic in Poland: A call for targeted HIV testing for those under suspicion of SARS‐CoV‐2
Authors: Suchacz Magdalena M. , Krankowska Dagny , Cybula Aneta , Kamerys Juliusz , Jabłonowska Elżbieta , Rozpłochowski Błażej , Bociąga‐Jasik Monika , Wiercińska‐Drapało Alicja 
Published: November 2022

AbstractObjectivesThe aim of this study was to analyse patients newly diagnosed with HIV who were originally admitted to hospitals with suspicion of COVID‐19.MethodsThis was a retrospective case series undertaken at four sites. Only adults with new HIV diagnosis and COVID‐19 exclusion hospitalized in 2020–2021 were included. Demographic, clinical and laboratory data were collected from medical records.ResultsTwenty‐five patients were included in the analysis: 19 men (76%), 11 of Ukrainian origin (44%). The median age was 38.5 years (range 25–59). The mode of HIV transmission was heterosexual for 11 (44%) patients, eight (32%) were men who have sex with men and three (12%) were people who inject drugs. The median duration of symptoms prior to hospital presentation was 20.6 days (range 3–90). The median number of SARS‐CoV‐2 tests per patient was 2.62 (range 1–7). All SARS‐CoV‐2 tests were negative. Screening for HIV was performed on average on the 18th day of hospitalization (range 1–36 days). Twenty‐three patients (92%) were late presenters, 22 (88%) had advanced disease, and 19 (76%) were in the AIDS stage. The median CD4 T‐cell count was 72 cells/μL (range 3–382). The rate of positive HIV testing at the two sites where it was available for people with suspected COVID‐19 was 0.13% (7/5458 during the study period).ConclusionsWe strongly recommend introducing the HIV screening test in the diagnostic algorithm for every patient suspected of having COVID‐19, presenting with clinical and/or radiological pulmonary symptoms.
Sintering properties and homogeneity of Ca2+‐doped .65Y2O3–.35YCr0.5Mn0.5O3 NTC ceramics
Authors: Wei Zichao , Deng Tengfei 
Published: November 2022

AbstractCeramics suitable for use over a wide temperature and having a negative temperature coefficient (NTC) based on .65Y2O3–.35YCr0.5Mn0.5O3‐doped with CaO were prepared by applying a solid‐state reaction at different temperatures (1500–1650°C). The physical properties and scanning electron microscopy results revealed that dense NTC ceramics could be obtained by sintering at >1550°C. The effect of two different sintering methods on the properties of the NTC ceramics was studied, and the results indicated that the NTC ceramics obtained by employing the two‐step sintering method exhibited better properties. The contents of Cr and Mn oxides in the NTC ceramic discs prepared by applying two‐step sintering (1600°C) exhibited a decreasing trend from inside to outside. To quantify the diffusion rate, Fick's second law was used, and the diffusion coefficients of Cr and Mn oxides in the NTC ceramics were found to be 5.20 × 10–5 and 2.36 × 10–5 cm2/s, respectively. Resistivity and temperature analyses indicated that the resistivity (ρ25), B25/100, and B700/1000 of the NTC ceramics were 1.61 × 106 Ω cm, 2367 K, and 2697 K, respectively, which are suitable for a wide temperature range.