bluuebunny/crossref_metadata_2025_split huggingface dataset:
Injectable Granular Hydrogels as Colloidal Assembly Microreactors for Customized Structural Colored Objects
Authors: Zhang Jing , Qin Yipeng , Ou Yangteng , Shen Yu , Tang Bao , Zhang Xiaoyun , Yu Ziyi 
Published: June 2022

AbstractWhile structural coloration has captured considerable interests across different areas in the past decades, the development of macroscopic objects with tailorable structural colors remains a challenge due to the difficulty of large‐scale fabrication of finely ordered nanostructures and poor processability of their constituent materials. In this work, a type of photonic granular hydrogel is developed as a novel printable ink for constructing customized structural colored objects. The magnetochromatic ink exhibits dynamic properties such as shear thinning and self‐healing, enabling direct writing of macroscopic structural colored patterns by extrusion 3D printing. Further, the modularity of the photonic ink allows additive color mixing, which obviates the need for arduous nano‐synthesis and expands on the color abundance of structural colored materials in a simple yet efficient manner. These characteristics grant novel photonic inks with great applicability to a variety of fields including switchable color displays, sensors, etc.
Trojan Nanobacteria System for Photothermal Programmable Destruction of Deep Tumor Tissues
Authors: Chu Binbin , Yang Yunmin , Tang Jiali , Song Bin , He Yao , Wang Houyu 
Published: June 2022

AbstractA novel bacteria‐based drug delivery system, termed “Trojan nanobacteria system”, has been developed in which nanoagents are internalized into engineered bacteria through bacteria‐specific maltodextrin (MD) transporters. Compared to the method of attaching nanoagents to bacterial surfaces, this Trojan system features higher payloads and better stability. In cancer therapy, Trojan nanobacteria can specifically discriminate the tumor region and then penetrate deep tumor tissues. Once in the tumor, the Trojan nanobacteria systems are able to destroy deep tumor tissues due to the combined effects of antitumor protein expression (e.g., tumor necrosis factor‐α, TNF‐α) and photothermal properties.
Highly Distorted Antimony(III) Chloride [Sb2Cl8]2− Dimers for Near‐Infrared Luminescence up to 1070 nm
Authors: Su Binbin , Geng Shining , Xiao Zewen , Xia Zhiguo 
Published: June 2022

AbstractZero‐dimensional (0D) hybrid metal halides with unique compositional and structural tunability appear as an emerging class of luminescent materials, but near‐infrared (NIR) emitters therein are largely unexplored to date. This study presents three novel 0D hybrid antimony chlorines with edge‐sharing [Sb2Cl8]2− dimers, showing unusual room‐temperature broadband NIR emission with the maximum emission wavelength up to 1070 nm. Photoluminescence studies and density functional theory calculation demonstrate that the emissions originate from the highly localized excitons, and that the confined [Sb2Cl8]2− dimers in these structures show low symmetry and a large degree of structural freedom. These hybrid antimony chlorines with [Sb2Cl8]2− dimers expand the range of new NIR materials in 0D metal halides.
Allenamide‐Initiated Cascade [2+2+2] Annulation Enabling the Divergent Total Synthesis of (−)‐Deoxoapodine, (−)‐Kopsifoline D and (±)‐Melotenine A
Authors: Zhao Liu‐Peng , Li Peng‐Juan , Wang Lijia , Tang Yong 
Published: June 2022

AbstractA facile method for the construction of the aspidosperma core from indoles functionalized with a nonterminal N‐allenamide and dimethyl methylenemalonate is described. Various polysubstituted tetracyclic spiroindolines (27 examples) were afforded in good yields (61–90 %) with >99/1 dr and >99/1 Z/E selectivity under mild conditions. The annulation reaction provides straightforward access to the tetracyclic spiroindoline skeleton with substituents at the C5 position occurring in many natural products. As an application of this reaction, the total synthesis of three important natural products, (−)‐deoxoapodine, (−)‐kopsifoline D and (±)‐melotenine A, was possible in short routes from tryptamine.
Study of the in vitro degradation and characterization of the HaCat keratinocytes adherence on electrospun scaffolds based polyvinyl alcohol/sodium alginate
Authors: Soto‐Quintero Albanelly , González‐Alva Patricia , Covelo Alba , Hernández Miguel Angel 
Published: June 2022

AbstractBiomaterial scaffolds house and direct cells to grow, exposing them to appropriate growth factors. Most of them are designed to degrade at a controlled rate as the new host tissue replaces them. Here, we show that scaffolds obtained through electrospinning of PVA with 3.5, 4.0, and 5.0 wt% of SA showed a gradual degradation rate under physiological conditions during 100 days of incubation. This behavior is proportional to the SA concentration used, with a mass loss of (41%, 47%, and 49% for each system) after 60 days. Moreover, the dielectric properties (EIS) of the scaffolds correlate with their degradation rate throughout the exposition period (100 days), as indicated by the observed decrease in resistance over time. The 4.0 wt% system showed the lowest capacitance value (1.5 10–5 F) and the highest resistance (4.6106 ohm‐cm2) behavior among all concentrations. Additionally, the morphological analysis through SEM and AFM showed a shrank in the surface morphology after the degradation process and determined the degree of roughness (Ra). Higher roughness prior to the cytocompatibility test promoted increased proliferation and adhesion of HaCat cells, as observed in the 4.0 wt% PVA/SA system (1422 nm Ra). These biomaterials have great potential in wound dressing applications.
Death‐associated protein kinases and intestinal epithelial homeostasis
Authors: Chen Huey‐Miin , MacDonald Justin A. 
Published: June 2022

AbstractThe family of death‐associated protein kinases (DAPKs) and DAPK‐related apoptosis‐inducing protein kinases (DRAKs) act as molecular switches for a multitude of cellular processes, including apoptotic and autophagic cell death events. This review summarizes the mechanisms for kinase activity regulation and discusses recent molecular investigations of DAPK and DRAK family members in the intestinal epithelium. In general, recent literature convincingly supports the importance of this family of protein kinases in the homeostatic processes that govern the proper function of the intestinal epithelium. Each of the DAPK family of proteins possesses distinct biochemical properties, and we compare similarities in the information available as well as those cases where functional distinctions are apparent. As the prototypical member of the family, DAPK1 is noteworthy for its tumor suppressor function and association with colorectal cancer. In the intestinal epithelium, DAPK2 is associated with programmed cell death, potential tumor‐suppressive functions, and a unique influence on granulocyte biology. The impact of the DRAKs in the epithelium is understudied, but recent studies support a role for DRAK1 in inflammation‐mediated tumor growth and metastasis. A commentary is provided on the potential importance of DAPK3 in facilitating epithelial restitution and wound healing during the resolution of colitis. An update on efforts to develop selective pharmacologic effectors of individual DAPK members is also supplied.
Dried blood spot as an alternative sample for screening of fatty acid, amino acid, and keto acid metabolism in humans
Authors: Laštovičková Lenka , Kopčil Michal , Kanďár Roman 
Published: June 2022

AbstractDried blood spot (DBS) is a simple and noninvasive sample collection technique allowing self‐collection at home. It can be used as an alternative sample for the screening of metabolism in humans because changes in the levels of some fatty acids (FAs), amino acids (AAs), and keto acids (KAs) can be associated with metabolic disorders (e.g., diabetes mellitus). In this study, we optimized three different methods that are sensitive enough for the determination of the aforementioned analytes from a small volume of biological material in DBS. A total of 20 AAs, 5 KAs, and 24 FAs were determined. This sampling technique was applied to prepare samples from 60 individuals by a finger prick. The samples were analyzed using chromatographic methods, and acquired data were statistically evaluated. Even though most analytes were higher in men, only five AAs, three KAs, and eight FAs showed significant gender dependency (α = 0.05). Asparagine, serine, and α‐ and γ‐linolenic acids showed significant age dependency (α = 0.05). Most statistically significant correlations were positive and were found within one category. This work shows that because of many benefits, the DBS sample could be a good alternative to whole blood sample collection for the screening of metabolism in humans, in general, or in individualized medicine. The chromatographic methods can be used in future research, for example, to set the reference range or plasma‐correction factors (various aspects such as age or gender should be considered).
Proton Acid Doped Superior Capacitive Performances of Pseudocapacitance Electrodes for Energy Storage
Authors: Liu Jian , Ma Xiaohang , Zi Zhenfa 
Published: June 2022

AbstractIn this work, three‐dimensional (3D) nanostructures of polyaniline nano‐sheets, nano‐particles, nano‐nets and nano‐flowers were synthesized with valine, sulfuric acid, sodium acetate and L‐phenylalanine as doping acids, respectively. Conductive polyaniline with 3D nanostructure was proven as an excellent energy storage material because of its superior electrical properties and unique structure. The porous structure not only greatly improved the charge transfer efficiency and reduced the resistance, but also improved the cycle stability and energy storage of the electrode material. Polyaniline nano‐flowers doped with L‐phenylalanine (PANI‐NF) showed a maximum specific capacitance of 580 F g−1(I=0.5 A g−1), a maximum energy density of 53.9 Wh kg−1, and excellent cycle stability at high current density.
NiCoP/Mo3Se4 Nano‐Heterojunction as a Promising Bifunctional Catalyst for Full‐Water Splitting under Low Cell Voltage
Authors: Wang Minmin , Song Wenwu , Miao Xu , Zhou Li , Wang Xunyue , Tang Yanfeng 
Published: June 2022

AbstractThe simultaneous manipulation of the catalytic activity and intrinsic electrical conductivity in a unified system is difficult yet meaningful to unravel the possible strategy that can enhance the water splitting performance. In this work, a low cost and highly efficient NiCoP/Mo3Se4 nano‐heterogeneous bifunctional catalyst was reported for full water splitting. Further analysis revealed the abundance interfaces in NiCoP/Mo3Se4 played a great role in optimizing the electronic structure of the nanoheterogeneous to efficient charge transfer. As expected, a low voltage of 1.90 V was needed to drive full water splitting at the high current density of 400 mA cm−2.
Chiral Motifs in Highly Interpenetrated Metal–Organic Frameworks Formed from Achiral Tetrahedral Ligands**
Authors: Wen Qiang , di Gregorio Maria Chiara , Shimon Linda J. W. , Pinkas Iddo , Malik Naveen , Kossoy Anna , Alexandrov Eugeny V. , Proserpio Davide M. , Lahav Michal , van der Boom Milko E. 
Published: June 2022

AbstractFormation of highly interpenetrated frameworks is demonstrated. An interesting observation is the presence of very large adamantane‐shaped cages in a single network, making these crystals new entries in the collection of diamondoid‐type metal–organic frameworks (MOFs). The frameworks were constructed by assembling tetrahedral pyridine ligands and copper dichloride. Currently, the networks’ degree of interpenetration is among the highest reported and increases when the size of the ligand is increased. Highly interpenetrated frameworks typically have low surface contact areas. In contrast, in our systems, the voids take up to 63 % of the unit cell volume. The MOFs have chiral features but are formed from achiral components. The chirality is manifested by the coordination chemistry around the metal center, the structure of the helicoidal channels, and the motifs of the individual networks. Channels of both handednesses are present within the unit cells. This phenomenon shapes the walls of the channels, which are composed of 10, 16, or 32 chains correlated with the degree of interpenetration 10‐, 16‐, and 32‐fold, respectively. By changing the distance between the center of the ligand and the coordination moieties, we succeeded in tuning the diameter of the channels. Relatively large channels were formed, having diameters up to 31.0 Å×14.8 Å.
Metal‐Mediated Directional Capping of Rod‐Packing Metal–Organic Frameworks
Authors: Hong Anh N. , Luong Diana , Alghamdi Mohammed , Liao Wei‐Cheng , Zhang Weiyi , Kusumoputro Emily , Chen Yichong , Greaney P. Alex , Cui Yongtao , Shi Jing , Bu Xianhui , Fokwa Boniface P. T. , Feng Pingyun 
Published: June 2022

AbstractTwo new rod‐packing metal–organic frameworks (RPMOF) are constructed by regulating the in situ formation of the capping agent. In CPM‐s7, carboxylate linkers extend 1D manganese‐oxide chains in four additional directions, forming 3D RPMOF. The substitution of Mn2+ with a stronger Lewis acidic Co2+, leads to an acceleration of the hydrolysis‐prone sulfonate linker, resulting in presence of sulfate ions to reduce two out of the four carboxylate‐extending directions, and thus forming a new 2D rod‐packing CPM‐s8. Density functional theory calculations and magnetization measurements reveal ferrimagnetic ordering of CPM‐s8, signifying the potential of exploring 2D RPMOF for effective low‐dimensional magnetic materials.
Heterolytic O−O Bond Cleavage Upon Single Electron Transfer to a Nonheme Fe(III)−OOH Complex
Authors: Bohn Antoine , Sénéchal‐David Katell , Rebilly Jean‐Noël , Herrero Christian , Leibl Winfried , Anxolabéhère‐Mallart Elodie , Banse Frédéric 
Published: June 2022

AbstractThe one‐electron reduction of the nonheme iron(III)‐hydroperoxo complex, [FeIII(OOH)(L52)]2+ (L52=N‐methyl‐N,N’,N’‐tris(2‐pyridylmethyl)ethane‐1,2‐diamine), carried out at −70 °C results in the release of dioxygen and in the formation of [FeII(OH)(L52)]+ following a bimolecular process. This reaction can be performed either with cobaltocene as chemical reductant, or electrochemically. These experimental observations are consistent with the disproportionation of the hydroperoxo group in the putative FeII(OOH) intermediate generated upon reduction of the FeIII(OOH) starting complex. One plausible mechanistic scenario is that this disproportionation reaction follows an O−O heterolytic cleavage pathway via a FeIV‐oxo species.
Grazing‐Incidence Texture Tomography and Diffuse Reflectivity Tomography of an Organic Semiconductor Device Array**
Authors: Smilgies Detlef‐M. , Koker Margaret K. A. , Li Ruipeng , Shaw Leo , Bao Zhenan 
Published: June 2022

AbstractThe use of grazing‐incidence scattering methods for the characterization of 2D patterned organic thin films is limited due to the elongated 1D footprint of the X‐ray beam on the sample. However, this characteristic feature can be turned into an advantage, when combined with tomographic reconstruction. In this pilot study we show, how the use of a chosen texture reflection and a diffuse reflectivity signal can each provide 2D images of the deposits, simultaneously revealing the organic film's crystal orientation and the location of the metal electrodes in a field‐effect transistor structure from a single sequence of diffraction images.
Clinical activity of CC‐90011, an oral, potent, and reversible LSD1 inhibitor, in advanced malignancies
Authors: Hollebecque Antoine , Salvagni Stefania , Plummer Ruth , Niccoli Patricia , Capdevila Jaume , Curigliano Giuseppe , Moreno Victor , de Braud Filippo , de Villambrosia Sonia Gonzalez , Martin‐Romano Patricia , Baudin Eric , Arias Marina , de Alvaro Juan , Parra‐Palau Josep L. , Sánchez‐Pérez Tania , Aronchik Ida , Filvaroff Ellen H. , Lamba Manisha , Nikolova Zariana , de Bono Johann S. 
Published: June 2022

BackgroundCC‐90011 is an oral, potent, selective, reversible inhibitor of lysine‐specific demethylase 1 (LSD1) that was well tolerated, with encouraging activity in patients who had advanced solid tumors or relapsed/refractory marginal zone lymphoma. The authors present long‐term safety and efficacy and novel pharmacodynamic and pharmacokinetic data from the first‐in‐human study of CC‐90011.MethodsCC‐90011‐ST‐001 (ClincalTrials.gov identifier NCT02875223; Eudract number 2015–005243‐13) is a phase 1, multicenter study in which patients received CC‐90011 once per week in 28‐day cycles. The objectives were to determine the safety, maximum tolerated dose, and/or recommended phase 2 dose (primary) and to evaluate preliminary efficacy and pharmacokinetics (secondary).ResultsSixty‐nine patients were enrolled, including 50 in the dose‐escalation arm and 19 in the dose‐expansion arm. Thrombocytopenia was the most common treatment‐related adverse event and was successfully managed with dose modifications. Clinical activity with prolonged, durable responses were observed, particularly in patients who had neuroendocrine neoplasms. In the dose‐escalation arm, one patient with relapsed/refractory marginal zone lymphoma achieved a complete response (ongoing in cycle 58). In the dose‐expansion arm, three patients with neuroendocrine neoplasms had stable disease after nine or more cycles, including one patient who was in cycle 46 of ongoing treatment. CC‐90011 decreased levels of secreted neuroendocrine peptides chromogranin A, progastrin‐releasing peptide, and RNA expression of the blood pharmacodynamic marker monocyte‐to‐macrophage differentiation–associated.ConclusionsThe safety profile of CC‐90011 suggested that its reversible mechanism of action may provide an advantage over other irreversible LSD1 inhibitors. The favorable tolerability profile, clinical activity, durable responses, and once‐per‐week dosing support further exploration of CC‐90011 as monotherapy and in combination with other treatments for patients with advanced solid tumors and other malignancies.
Comparative Bioavailability of a Single Dose of Trametinib (TMT212) Containing 9% vs 11% Dimethyl Sulfoxide in Randomized Healthy Volunteers to Assess Long‐Term Storage at Room Temperature
Authors: Tan Eugene Y. , Chiparus Ovidiu , Choudhury Somesh , Kim Christina , Lau Mike , Ziltener Christoph , Ilankumaran Palanichamy 
Published: June 2022

AbstractStorage of trametinib tablets outside of 2‐8°C protected from moisture may lead to loss of dimethyl sulfoxide (DMSO) and adversely impact trametinib bioavailability. In this open‐label, phase 1, single‐dose, randomized, 2‐treatment, 2‐period crossover study in healthy volunteers, bioavailability of a single 2‐mg tablet of trametinib containing 9% DMSO (test formulation), corresponding to the lowest DMSO content in the tablet after storage at 25°C for 36 months, was evaluated vs bioavailability of a 2‐mg tablet containing 11% DMSO (reference formulation). Sixty‐five percent of subjects (n = 39/65) were men, and mean (standard deviation) age was 45.6 (11.17) years. Time to reach maximum plasma concentration occurred at 1.5 hours after dosing. The geometric mean ratio (90%CI) comparing 2‐mg trametinib containing 9% DMSO with 2‐mg trametinib containing 11% DMSO for area under the concentration‐time curve from time 0 to the last measurable plasma concentration sampling time was 0.890 (0.848‐0.935), suggesting the 2 formulations have similar bioavailability. The majority of adverse events were mild, with 1 subject experiencing 1 grade 3 headache. These results indicated that storage of trametinib at room temperatures ≤25°C during the overall shelf life of 36 months would not negatively impact trametinib bioavailability.
Influence of non‐uniform magnetic field on relativistic q‐Gaussian laser pulses propagating in magnetized plasmas
Authors: Daraei Mohammad Esmaeil , Abedi‐Varaki Mehdi 
Published: June 2022

AbstractIn this work, the influence of a non‐uniform magnetic field on the self‐focusing of relativistic q‐Gaussian (QG) laser pulse propagating in magnetized plasma is studied. Utilizing the non‐linear Schrodinger equation with higher‐order paraxial approximation, the higher‐order terms of the dielectric function and the eikonal in the presence of a non‐uniform magnetic field have been obtained. Numerical results reveal that while the non‐uniform magnetized field decreases, the pulse width parameter (g) decreases, and subsequently the spot‐size of the laser declines too. As a consequence, the QG laser pulse will be more focused. Besides, it is shown that increasing the values of q‐parameter leads to a decline in self‐focusing qualities and, at lower values of q‐parameter, sharp self‐focusing of QG laser pulse is observed. Furthermore, it is found that when the QG laser pulse is propagated in the magnetized plasma, the amplitude of the pulse width decreases with decreasing the δ‐parameter, and consequently, the laser pulse becomes more compressed. Moreover, it is observed that the application of a non‐uniform magnetic field improves the self‐focusing of the QG laser pulse propagated through magnetized plasma.
Immunophenotypic characteristics of ZNF384 rearrangement compared with BCR‐ABL1, KMT2A rearrangement, and other adult B‐cell precursor acute lymphoblastic leukemia
Authors: Wang Ya‐Zhe , Qin Ya‐Zhen , Chang Yan , Yuan Xiao‐Ying , Chen Wen‐Min , He Ling‐Ling , Hao Le , Shi Wei‐Hua , Jiang Qian , Jiang Hao , Huang Xiao‐Jun , Liu Yan‐Rong 
Published: June 2022

AbstractBackgroundZNF384 rearrangement has been recently identified as a new subtype of B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). However, comprehensive studies clarifying immunophenotypic features and discriminating them from non‐ZNF384 in adult BCP‐ALL remain scarce to date.MethodsFlow cytometric assessments were retrospectively performed in 43 patients with ZNF384 rearrangement, 45 with BCR‐ABL1, 29 with KMT2A rearrangement and 44 with other BCP‐ALL in the analysis cohort.ResultsCD33‐ and CD13‐positive frequencies were significantly higher in patients with ZNF384 rearrangement than in those with non‐ZNF384; however, no significant difference was observed in CD10‐ and CD123‐positive frequencies. Analysis of antigen‐positive cell proportion and median fluorescence intensity (MFI) further indicated that patients with ZNF384 rearrangement had significantly lower CD10 and higher CD33, CD13, and CD123 proportion and MFI. However, compared with KMT2A rearrangement, the CD10 expression in patients with ZNF384 rearrangement was higher, with the median percentage and MFI of 36.16 (3.63–94.79)% versus 4.53 (0.03–21.00)%, and 4.50 (0.86–32.26) versus 2.06 (0.87–4.04), respectively (p < 0.0001). Furthermore, compared with BCR‐ABL1 and other BCP‐ALL, ZNF384 rearrangement had significantly higher CD33 and CD13 proportion and MFI (p < 0.0001 and p < 0.05, respectively). In addition, higher CD123 proportion and MFI in ZNF384 rearrangement than those in the other three groups were reported for the first time (p < 0.01). A flow cytometry scoring system, including CD10%, CD33MFI, CD13%, and CD123MFI, was proposed and verified to predict ZNF384 rearrangement with high sensitivity and specificity, that is, 76.74% and 91.53% in the analysis and 87.50% and 91.30% in the validation cohort.ConclusionsThe multiparameter immunophenotypic scoring system could suggest ZNF384 rearrangement.