bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of intestinal parasites and associated risk factors among HIV/AIDS patients attending at anti-retroviral treatment (ART) clinic at Mizan-Tepi university teaching hospital, southwest Ethiopia
Authors: Abayneh Mengistu , Duguma Tadesse 
Published: April 2022

Abstract
Background
Intestinal parasitic infections are still very common, especially in areas where immune-compromised patients like HIV/AIDS patients are high prevalent. Therefore, the aim of this study was to assess the prevalence of intestinal parasite and risk factor among HIV/ AIDS patients attending ART clinic in Mizan-Tepi university teaching hospital, Southwest Ethiopia.
Method
A cross -sectional survey was conducted from July to September, 2021. A total of 191 study subjects were participated in this study. A structured questionnaire was used for collecting socio-demographic and risk factors data. Stool sample was collected and processed using direct wet mount, formol-ether concentration technique and modified Ziehl-Neelson staining techniques. Data was analyzed using statistical package for social sciences (SPSS) Version 25 software and logistic regressions were applied to assess any association between explanatory factors and outcome variables.
Result
From a total of 191 stool samples, 67 (35.1%) were positive for intestinal parasites. The prevalence of intestinal parasites among patients on-ART was 31.5% (45/143) and 45.8% (22/48) among ART naïve group. Entamoeba histolytica/dispar (7.7%) and (12.5%) and Giardia lamblia (7.0%) and (10.4%) was the most predominant parasites detected both in ART and ART naïve groups (p > 0.05). Drinking untreated water (AOR = 0.13; 95% CI: 0.016–1.012), consuming raw food (AOR = 0.23; 95% CI: 0.025–2.108), eating unwashed raw vegetables (AOR = 2.26; 95% CI: 1.052–4.843); CD4 count < 200cells/ mm3 (AOR = 0.22; 95% CI: 0.062–0.798), CD4 count 200-500cells/mm3 (AOR = 0.40; 95% CI: 0.195–0.811), WHO stage II (AOR = 0.30; 95% CI: 0.156–0.589), WHO stage III (AOR = 0.32; 95% CI: 0.108–0.917) and viral load ≥ 150 copies/ml (AOR = 0.44; 95% CI: 0.220–0.873) were showed significant association with prevalence of intestinal parasite.
Conclusion
In this study, higher rate of intestinal parasitosis were associated with hygienic practices like drinking untreated water, consuming raw food and eating unwashed raw vegetables and with some clinical findings such as lower CD4 counts, increased viral load and being WHO stage II & III. Therefore, public health measures and adherence to ART should be strengthened to improve the immune status and to reducing vulnerability of the patients for intestinal parasites.
Development of an efficient transgenic system of Lagenaria siceraria using seed germination pouches as a growth carrier
Authors: Wang Ying , Huang Lijuan , Li Yanwei , Feng Zishan , Mu Zihan , Wang Jian , Wu Xinyi , Wang Baogen , Lu Zhongfu , Li Guojing , Wu Xiaohua 
Published: April 2022

Abstract
Bottle gourd [Lagenaria siceraria (Mol.) Standl.] is one of the most common horticultural and medicinal crops. Genetic transformation is a rate-limiting step in unraveling the function of genes and molecular breeding in this non-model crop. In this study, we established an optimized protocol for transformation using a seed germination pouch as a growth carrier and developed bottle gourd composite plants. Overground explants were inoculated with Agrobacterium rhizogenes strain R1000, which harbored a binary vector pBI121 carrying the GUS reporter gene. The integration of GUS into transgenic roots was confirmed via reverse transcription-polymerase chain reaction and histochemical staining. Furthermore, we screened for desirable genotypes from 14 bottle gourd germplasm collections based on the number of induced roots, transformation efficiency, and induction rate, and “Changguang” (transformation efficiency, approximately 36.8%) was selected as the genotype suitable for hairy root induction in bottle gourd. The optimized protocol presented here is a rapid, suitable, and efficient tool for studying the function of genes and root biology of bottle gourd in the future.
Determining the Key Performance Indicators of Human Resource Management of Military Hospital Managers; A TOPSIS Study
Authors: fanaei Sadegh , Zareiyan Armin , shahraki saeid , Mirzaei Abasat 
Published: April 2022

Abstract
BackgroundHuman resource management in health centers influences the management of the military health system, and the development of the military health system due to its complexity requires sustainable development and improving the quality of services. As a result, this study aims to determine the key performance indicators of human resource management for military hospital managers.MethodsThis cross-sectional study was performed by the TOPSIS method in the fall of 2021. This study used a checklist consisting of 20 performance indicators of human resource management, which were scored by 20 senior military hospital managers based on two criteria: "importance" and "measurability in military hospitals". The Shannon entropy method was used to weight the indicators, and the BT-TOPSIS Solver software was used to analyze and prioritize them.ResultsAmong the 20 indicators in human resource management, the staff satisfaction index in military hospitals, the competitiveness rate of salaries in military hospitals relative to the national sector, the number of permanent staff in military hospitals, and the percentage of contract labor costs in military hospitals have the highest coefficient, respectively.ConclusionsOrganizational performance and human resource management have a significant relationship. As a result, human resource management should pay special attention to the professional and personal development of human resources, as this has an impact on the performance of the organization in the long run. In light of the sensitive nature of human resource management and its crucial role in achieving any organization's strategic goals, selecting appropriate indicators is essential.The Department of Military Health requires indicators unique to the military sector to assess the human resource management of the military hospital, since according to the existing circumstances, the indicators of the military sector and those of the civilian sector are different.
Comparable effectiveness of 45-min and 20-min post-infusion scalp cooling time in preventing paclitaxel-induced alopecia – a randomized controlled trial
Authors: Lugtenberg Rieneke T , Hurk Corina JG van den , Smorenburg Carolien H , Mosch Linda , Houtsma Danny , Deursen Margaret AG den Hollander - van , Kaptein Ad A , Gelderblom Hans , Kroep Judith R 
Published: April 2022

Abstract
Purpose
Scalp cooling can prevent chemotherapy-induced alopecia (CIA). Previously, the post-infusion cooling time (PICT) could be successfully reduced in docetaxel-treated patients from 90 to 45 and 20 minutes. Therefore it seems plausible that the PICT can be shortened for paclitaxel-treated patients as well.
Methods
Patients treated with weekly paclitaxel were included in this multi-center trial and randomly assigned to a PICT of 45 or 20 minutes. The results were compared to a standard PICT of 90 minutes, derived from prospective collected data from the Dutch Scalp Cooling Registry. The primary endpoint was the percentage of patients who decide to not wear a wig or head covering. Secondary endpoints were the degree of CIA assessed with the Dean scale for assessment of hair loss; alopecia graded according to NCI CTC toxicity version 4.03 (CTCAE4.03); tolerance of scalp cooling and perceived distress of CIA.
Results
91 patients were enrolled in this study, 74 patients were evaluable for hair loss. Hair preservation was successful in 27 patients (75%) with a PICT of 45 minutes and in 31 patients (82%) with a PICT of 20 minutes. There was no difference in success rate with the standard PICT of 90 minutes (85%, p = 0.29). Similar success rates were seen when using the Dean sale and CTCAE assessment, with no differences between groups (p = 0.12 and p = 0.38).
Conclusions
A 20 minute PICT is as effective as 45 and 90 minutes to prevent weekly paclitaxel-induced alopecia and should be the new standard of care.
Preoperative orbital CT scan findings in patients with nasolacrimal duct obstruction and its impact on surgical planning
Authors: Medghalchi Abdolreza , Alizadeh Yousef , Dourandeesh Maryam , Arzpeima Sima Fallah , Soltani-Moghadam Reza , Akbari Mitra , Khadem Sara , Kazemnejad Ehsan 
Published: April 2022

Abstract
Objective
External dacryocystorhinostomy (DCR) failure is sometimes due to pathologies located within the nasal cavity. Preoperative computerized tomography (CT) scan is useful in the assessment of nasolacrimal drainage and adjacent anatomical structures; however, it is not routinely performed before DCR. The present study evaluates abnormal findings in CT scans of patients with nasolacrimal duct obstruction (NLDO) and its effect on changing treatment approaches.
Methods
This prospective descriptive cross-sectional study included 162 patients with NLDO. All the patients underwent a supine axial CT scan. Patients with signs of rhinosinusitis, sinus mucositis, nasal septal deviation, nasal polyps or masses, and turbinate deformities were referred to an otolaryngologist. The rest of the patients underwent external DCR. The demographics and radiologic characteristics of the patients undergoing CT scans and their effect on changing treatment approaches were evaluated.
Results
The study participants included 162 patients with a mean ± SD age of 62.5 ± 14.0 years (age range of 35–93 years). The percentage of endonasal DCR in cases with an abnormal nasal cavity on CT scan was almost 30% higher compared to those without this problem (59.6% vs. 30.2%). Septum deviation and turbinate deformity led to 3.6-fold and 3.9-fold changes in the surgical approach, respectively.
Conclusion
A significant association existed between the sinonasal pathologies in patients with NLDO and changing surgical approach. It is believed that a preoperative CT scan is necessary to detect such pathologies and manage them appropriately.
Application of the Theory of Planned Behaviour to understand physical activity intentions and behavior among Korean breast cancer survivors
Authors: Min Jihee , Yu Ye-Won , Lee Jeongmin , Yeon Sujin , Park Ha-Nui , Lee Joon Sung , Courneya Kerry S. , Park Hyung Seok , Kim Seung Il , Jeon Justin 
Published: April 2022

Abstract
Purpose: The purpose of this study was to apply the Theory of Planned Behavior (TPB) to understand physical activity intentions and behaviors among Korean breast cancer survivors.Methods: A total of 286 Korean breast cancer survivors (Mage52.3±8.3) completed a self-reported survey administered face-to-face by a trained interviewer. The survey assessed the physical activity frequency and intensity in a typical week after breast cancer diagnosis, demographic factors, and theory of planned behavior variables including attitude, subjective norm, perceived behavioral control (PBC), planning, and intentions to participate in physical activity. We used structural equation modeling to examine the direct and indirect effects of the TPB variables on physical activity intentions and behavior. Covariates included age, cancer stage, and clinical treatment.Results: Confirmatory factor analyses indicated a satisfactory model fit. We observed direct effects for instrumental attitude (ß=0.34, p<0.001), subjective norm (ß=0.12, p<0.05), and PBC (ß=0.57, p<0.001) on physical activity intentions. PBC (ß=.17, p<0.01) and physical activity intentions (ß=0.46, p<0.01) had direct effects on planning. PBC (ß=0.28, p<0.01) and planning (ß=0.22, p<0.01) had direct effects on physical activity behavior. Conclusion: The TPB was a useful model for understanding Korean breast cancer survivors’ physical activity intentions and behavior. Interventions that can enhance attitudes, subjective norm, PBC, intention, and planning may facilitate physical activity intentions and behaviors in this population.
What predicts people’s adherence to COVID-19 misinformation? A retrospective study using a nationwide online survey among adults residing in the United States
Authors: Kim Sooyoung , Capasso Ariadna , Ali Shahmir H. , Headley Tyler , DiClemente Ralph J. , Tozan Yesim 
Published: April 2022

Abstract
Background: Tackling infodemics with flooding misinformation is key to managing the COVID-19 pandemic. Yet only a few studies have attempted to understand the characteristics of the people who believe in and adhere to misinformation. Methods: Data was used from an online survey that was administered in April 2020 to 6,518 English-speaking adult participants in the United States. We created binary variables to represent four misinformation categories related to COVID-19: general COVID-19-related, vaccine/anti-vaccine, COVID-19 as an act of bioterrorism, and mode of transmission. Using binary logistic regression and the LASSO regularization, we then identified the important predictors of adherence to each type of misinformation. Nested vector bootstrapping approach was used to estimate the standard error of the LASSO coefficients. Results: About 30% of our sample reported adhering to at least one type of COVID-19-related misinformation. Adherence to one type of misinformation was not strongly associated with adherence to other types. We also identified 58 demographic and socioeconomic factors that predicted people’s susceptibility to at least one type of COVID-19 misinformation. Different groups, characterized by distinct sets of predictors, were susceptible to different types of misinformation. There were 25 predictors for general COVID-19 misinformation, 42 for COVID-19 vaccine, 36 for COVID-19 as an act of bioterrorism, and 27 for mode of COVID-transmission. Conclusion: Our findings confirm the existence of groups with unique characteristics that adheres to different types of COVID-19 misinformation. Findings are readily applicable by policymakers to inform careful targeting of misinformation mitigation strategies.
The variable clinical spectrum of nephroblastomatosis – results from the German Society of Pediatric Oncology and Hematology (GPOH) childhood kidney tumor group.
Authors: Furtwängler Rhoikos , Schenk Jens-Peter , Friesenbichler Waltraud , Gessler Manfred , Wagenpfeil Stefan , Kager Leo , Müller Marina , Welter Nils , Fuchs Jürgen , Warmann Steven , Meier Clemens M , Hubertus Jochen , Rübe Christian , Vokuhl Christian , Melchior Patrick , Graf Norbert 
Published: April 2022

Abstract
Background: Nephroblastomatosis is defined histologically as ≥2 microscopic foci of nephrogenic rests. In contrast, clinicans’ nephroblastomatosis consists of single, multiple or diffuse hyperplastic nephrogenic rests (HNR) apparent on imaging as a renal tumor. Methods: Analysis of 78 patients having clinically apparent uni- or bilateral nephroblastomatosis out of 2347 patients registered in two consecutive International Society of Pediatric Oncology SIOP93-01/GPOH and SIOP2001/GPOH renal-tumor studies (1993 - 2014). Results: Median follow-up and age at diagnosis was 9.2 years and 13 months (0-12.7 years). 59% of patients were female, 57% had bilateral and 53% multifocal or diffuse HNR. Imaging diagnosis was conclusive in 67% when reviewed centrally versus 30% without review (p=0.015). 27% of patients developed nephroblastoma(s). 45% had high-risk, 30% intermediate-risk histology and 25% upfront-surgery-blastemal subtype. 5-year-event-free-(EFS), nephroblastoma-free-(NFS) and overall-survival(OS) were 60.7%, 79.8% and 95.5%, respectively. Univariate risk factors for EFS/NFS were female gender (p<0.001/p=0.031), bilateral(p=0.002/p=0.03), diffuse HNR at diagnosis (p<0.001/p=0.016), and non-complete-remission(non-CR) at end of first-line-treatment (both p<0.001). Gender and non-CR remained significant in multivariate COX regression analysis for EFS(p=0.005/p<0.001), non-CR also for NFS(p=0.002). 34 patients achieved CR within 12 weeks from diagnosis: 25 of them were only followed, 9 received further chemotherapy. EFS was 78% and 100%, respectively.Conclusion: Patients having Nephroblastomatosis have an excellent OS but need an extended follow-up for more than a decade. A short treatment is sufficient for those who achieved CR within 12 weeks. Bilateral and diffuse HNR are significant risk factors. Consensus terminology is needed for future trials to facilitate true comparability of results.
Tele-yoga in the management of Ankylosing Spondylitis amidst COVID pandemic: A Prospective Randomized Controlled Trial
Authors: Singh Jyoti , Metri Kashinath , Tekur Padmini , Mohanty Sriloy , Singh Amit , R Nagaratna 
Published: April 2022

Abstract

Patients with Ankylosing Spondylitis (AS) often report mental and physical problems and have a poor quality of life (QoL). This study intended to investigate the efficacy of a 3-months tele-yogic intervention on the disease activity, inflammatory markers, and mental health measures in patients with AS. Hundred and twenty AS patients were assigned to either the yoga intervention or control arm. The yoga intervention arm (YG) (n = 57) received a 60-minutes structured yoga module for 3-months on online in addition to standard medical care. The control (CG) participants (n = 52) followed only standard care for the same period. BASDAI, BASFI, ASQOL, psychological and inflammatory biomarkers were assessed at baseline and three months. YG showed significant improvement in BASDAI (p = 0.001), anxiety (p = 0.0004), and depression (p = 0.001) at 3-months compared to the baseline. The CG showed no change. After 3-months, the intervention resulted in a significant improvement in BASDI (-0.79; 95% CI (-1.3, to -0.29); p = 0.0021),BASFI (-0.86; 95% CI (-1.59, to -0.14); p = 0.0193), anxiety (-0.42; 95% CI (-0.84 to -0.01); p = 0.0468), and AS-QoL (-3.37; 95% CI (-5.21, to 1.53); p = 0.0004) compared to the CG. The present study suggests that Yoga helps to improve the pain, functional index, and mental health among patients with AS. The tele-yoga intervention is feasible and effective in the management of AS.
Expression relationship and significance of NEAT1 and miR-27a-3p in serum and cerebrospinal fluid of patients with Alzheimer's disease
Authors: feng heqiang , HE LIJIE , chen zongnan , wang jing 
Published: April 2022

Abstract
Objective To explore the expression relationship and significance of long chain non-coding RNA nuclear-enriched abundant transcript 1 (LncRNA NEAT1) and miR-27a-3p in serum and cerebrospinal fluid of patients with Alzheimer's disease (AD).Methods Sixty-six AD patients received by the Department of Neurology of our hospital from October 2019 to September 2021 were gathered, according to the Clinical Dementia Rating Scale (CDR) score, they were grouped into mild group (≤1 point, n=41) and moderate-to-severe group (>1 point, n=25).Another 32 cases of serum and cerebrospinal fluid samples from outpatient physical examination personnel were regarded as the control group. The general materials on all subjects was recorded and cognition was assessed;real-time quantitative PCR was performed to measure the expression levels of miR-27a-3p and NEAT1 in serum and cerebrospinal fluid;enzyme-linked immunosorbent assay was performed to measure the protein levels of β-amyloid precursor protein cleaving enzyme 1 (BACE1), β-amyloid (Aβ) 40 and Aβ42 in cerebrospinal fluid;Spearman's method was performed to analyze the correlation of serum miR-27a-3p and NEAT1 levels with MMSE and MoCA scores;Pearson method was performed to analyze the correlation between serum miR-27a-3p and NEAT1 levels and Aβ deposition standard uptake value ratio (SUVR) and cerebrospinal fluid miR-27a-3p, NEAT1, BACE1, Aβ42 and Aβ40 levels.Results The MMSE score, MoCA score, serum miR-27a-3p level, cerebrospinal fluid miR-27a-3p, Aβ42 levels and Aβ42/Aβ40 ratio of AD patients in mild group and moderate-to-severe group were all lower than those in the control group, and the moderate-to-severe group were lower than the mild group (all P<0.05);the serum NEAT1 level, SUVR, and cerebrospinal fluid NEAT1 and BACE1 levels were higher than those in the control group, and the moderate-to-severe group were higher than the mild group (all P<0.05).Serum NEAT1 level in AD patients was positively correlated with SUVR, cerebrospinal fluid NEAT1 and BACE1 (r=0.350, 0.606, 0.341, all P<0.05);serum miR-27a-3p level was positively correlated with cerebrospinal fluid miR-27a-3p level (r=0.695, P<0.05), and negatively correlated with SUVR and cerebrospinal fluid BACE1 level (r=-0.521, -0.447, both P<0.05).Conclusions The expression trends of NEAT1 and miR-27a-3p in the serum and cerebrospinal fluid of AD patients are consistent, the level of NEAT1 is increased, and the level of miR-27a-3p is decreased. The levels of the two are negatively correlated, which is related to the degree of Aβ deposition in the brain of AD patients and is involved in the progression of AD.
Antioxidant activation, cell wall reinforcement and ROS regulation promote resistance to waterlogging stress in hot pepper (Capsicum annum L.)
Authors: Gong Xuefeng , Xu Yi , Li Hong , Chen Xin , Song Zhanfeng 
Published: April 2022

Abstract
Hot pepper (Capsicum annuum) is one of the oldest domesticated crops in the world. Pepper has poor waterlogging tolerance and flooding often leads to plant death and yield reduction. It is important to understand the molecular mechanisms involved in pepper waterlogging tolerance to cultivate new varieties with stronger tolerance. In the present study, we found that the growth rate of waterlogging-tolerant pepper varieties was not strongly affected after five days of exposure to flooding. Physiological data showed that chlorophyll content was not strongly affected by flooding, but stomatal conductance changed significantly 0–5 days after flooding and the net photosynthesis rate changed significantly 5–10 days after flooding. We also found that waterlogging-tolerant varieties showed significantly higher root activity after flooding for 10 days than a control. This suggests that the impact of flooding is related to changes in the root environment, which indirectly affects photosynthesis. A comparison of transcriptome data found that antioxidase genes, cell wall synthesis pathway genes and calcium ion regulation pathway genes may also be related to waterlogging tolerance. Other genes identified in tolerant peppers include those related to lignin synthesis regulation, reactive oxygen species (ROS) regulation pathways and others related to stress resistance. We recorded significant changes in the expression levels of these genes at five days after waterlogging, which was consistent with a significant increase in oxidase content that was also observed on the fifth day after flooding. Our results show that ROS regulation, increases in antioxidase activity, the accumulation of lignin and the expression of stress resistance genes may facilitate flooding resistance in waterlogging-tolerant peppers to flooding stress in the early stage. These results provide a foundation for further analysis of the molecular mechanisms responsible for waterlogging tolerance in pepper and may be a useful reference for the breeding of other Solanaceae plants.