bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tratamiento endovascular e indicadores predictivos de complicaciones y mortalidad en la hemorragia subaracnoidea espontanea de origen aneurismática
Authors: Criollo P. Jefferson , Mora Henin , Cruz Karina , Torres Larry , Cedeño Wilmer , Solá Juan , Castañeda Judy 
Published: July 2022

Introducción: La causa más frecuente de hemorragia subaracnoidea espontánea es la ruptura aneurismática (75-80 %), con una elevada tasa de mortalidad 40-50 %. Objetivo: Determinar los principales indicadores predictivos de complicación y mortalidad en hemorragia subaracnoidea espontánea de origen aneurismático, en pacientes que recibieron tratamiento endovascular. Pacientes y métodos: Estudio prospectivo – retrospectivo, analítico, observacional de los pacientes con hemorragia subaracnoidea de origen aneurismático que recibieron tratamiento endovascular. Los datos obtenidos al ingreso hospitalario incluyeron edad, género, procedencia, escala de Glasgow, escala de Hunt y Hess, clasificación tomográfica de Fisher, complicaciones médicas, características del aneurisma, momento del tratamiento endovascular. Resultados: Se evaluaron 16 pacientes, 6 hombres (37,5 %) y 10 mujeres (62,5%), con promedio de edad >61 años en 8 pacientes (50 %).Fallecieron 4 (25%) y sobrevivieron 12 (75 %). En la escala Fisher se obtuvo una mortalidad del 42,85 % en grado III correlacionándose con la escala de Hunt y Hess y escala de la federación mundial de neurocirugía grado V – IV, respectivamente, con una tasa de mortalidad del 100 %. La complicación más frecuente que se encontró es el vasoespasmo más isquemia, con un total de 43,75 % y una mortalidad de 28,57 %. Conclusión: Los factores que influyeron en el pronóstico de los pacientes con hemorragia subaracnoidea fueron la edad y género. Se observó una relación directa en cuanto a las escalas de valoración clínicas e imagenologías con la mortalidad, a decir a mayor gradación a la escala mayor mortalidad.
Remote sensing techniques in the study of structural and geotectonic features of Iturup Island (the Kuril Islands)
Authors: Talovina Irina , Krikun Nikita , Yurchenko Yurii , Ageev Aleksey 
Published: July 2022

The article presents structural and geotectonic features of Iturup Island, the largest island in the Greater Kuril Ridge, a unique natural site, which can be considered as a geological reference. The structural and geotectonic analysis carried out on the basis of a comprehensive study of the new Earth remote sensing data, maps of anomalous geophysical geophysical fields, and other geological and geophysical materials using modern modelling methods made it possible for the first time to identify or clarify the location of previously discovered discontinuous faults, typify them and determine the kinematics, as well as to establish a more reliable spatial relationship of the identified structures with magmatism with the stages of the geological development of the region. The constructed diagram of the density distribution of the zones with increased tectonic fracturing shows a significant correlation between the distribution of minerals and weakened areas of the Earth's crust and can be used as an alternative method for predicting minerals in the study region, especially in remote and hard-to-reach areas. The presented approach can be extended to the other islands of the Greater Kuril Ridge, thereby bringing research geologists closer to obtaining the answers to questions about the features of the geotectonic structure and evolution of the island arc. The use of customized software products significantly speeds up the process of interpreting a large array of geological and geophysical data.
El método comunicativo para la innovación en la enseñanza de la destreza oral, en inglés como lengua extranjera
Authors: Mantilla Cabrera Luis Francisco , Carrillo Rodríguez Mayra Alexandra , Guambo Yerovi Enrique Jesús , Rivadeneira Mora Jimena Elizabeth 
Published: July 2022

Introducción. Esta investigación presenta la correlación de las variables Método Comunicativo y el proceso enseñanza - aprendizaje de la habilidad de hablar inglés. Esta propuesta se aplicó a los estudiantes de la Carrera de Mantenimiento de la ESPOCH. Objetivo. Se determinó el nivel de influencia de las técnicas basadas en el Método Comunicativo en la mejora de la destreza oral. Metodología. Se utilizaron dos métodos, técnicas e instrumentos para la intervención. Mediante su aplicación fue posible obtener datos con un alto grado de exactitud y confiabilidad. Un análisis estadístico descriptivo e inferencial mostró una mejora significativa en la habilidad para hablar en inglés en la comparación entre el pre y el post test. Para esta prueba se utilizó una prueba y rubrica de Cambridge nivel B1, para determinar la mejora cualitativa se utilizó una guía de observación. Resultado. El instrumento test evidenció una mejora de 2.3 puntos en la destreza oral. Al aplicar la prueba T-student con los datos obtenidos se ratificó el cambio luego de la aplicación del proyecto. La guía de observación mostró la correlación bilateral entre las variables. Todos los resultados demostraron el impacto positivo del Método Comunicativo en la destreza oral en inglés. Conclusión Se concluyó que el proyecto aporta significativamente en la enseñanza del idioma inglés y específicamente mejora la destreza oral. Se recomienda continuar investigando sobre este método para generar nuevos conocimientos para la enseñanza de lenguas extranjeras.
Semantic Shift of English Internet Slangs Used in Social Media: Morphosemantic Analysis
Authors: Rahman Oon Suzana , Sobarna Cece , Sujatna Eva Tuckyta Sari , Indriyani Lia Maulia 
Published: July 2022

The aim this research are to identify the most common morphological process through word formation found in the lexical of English Internet slang, and to identify the most common type of shift of meaning used by netizen on social media.The research Methodology applied in this research is descriptive qualitative-textual analysis (Bhawna & Gobind (2015) and Smith (2017). The data sources are taken from facebook, twitter and teenage English Slang that are selectively chosen on the basis of criteria.The Theory of English Internet Slang taken from Crystal (2003, 2005, 2011, 2013), Gua and Dai (2019). The research findings are:No Morphological process 72% , derivation consisted of 16%, Compounding 4%, Coinned 4%, Clipping 4%. Whereas the type of semantic changes, mostly narrowing consists of 78%, The words that do not change the meanings are 28%. It is recommended for further reseach which is still open for semantic field, especially under the discussion on figurative meaning Tujuan peneltian ini adalah untuk mengidentifikasi proses morfologi yang paling banyak ditemukan di dalam pembentukan kata internet slang berbahasa Inggris, dan untuk mengidentifikasi jenis pergeseran makna yang paling banyak digunakan dalam kata internet slang berbahasa Inggris. Metodologi penelitian yang digunakan yaitu descriptive qualitative –textual analysis dari (Bhawna & Gobind (2015) and Smith (2017). Teori Internet Slang Berbahasa Inggris yang digunakan dalam penelitian berasal dari Crystal (2003, 2011, 2013), Gua dan Dai (2019).Temuan penelitian ini yaitu: tidak terjadi proses morfologis 72%, derivation consisted of 16%, Compounding 4%, Coinned 4%, Compounding 4%. Sedangkan jenis perubahan semantik, yaitu: narrowing yang terdiri dari 72%, Makna kata yang tidak mengalamii pergeseran, yaitu 28 %. Peneliti merekomendasikan untuk penelitian selanjunya yang masih terbuka terutama di bidang semaantik dalam pembahasan makna figurative
Neutrophil-to-Lymphocyte Ratio Predicts Restenosis After Drug-Coated Balloon Therapy for Femoropopliteal Artery Lesions: A Retrospective Study
Authors: Wang Zhihong , Sheng Lei , Gu Hongbin , Yang Fan , Xie Huajie , Li Mingfei 
Published: July 2022

BackgroundPeripheral artery disease (PAD) is a common atherosclerotic vascular disease. The use of drug-coated balloon (DCB) for the treatment of femoropopliteal artery disease has gradually increased. A certain percentage of patients developed target lesion restenosis after DCB treatment of the femoral popliteal artery. The neutrophil-to-lymphocyte ratio (NLR) is closely related to the level of inflammatory activity and has predictive value for atherosclerotic vascular disease. This study aimed to analyze the relationship between NLR and 1-year restenosis after DCB for femoropopliteal artery disease.MethodsPatients with femoropopliteal artery disease who were treated with DCBs at our hospital from May 2016 to December 2020 were retrospectively included. Baseline data during the patient’s first hospital stay and data during follow-up were collected. Demographic data, laboratory test results, lesion examination results, and major adverse events during the follow-up period were collected. Logistic regression was used to analyze the factors associated with restenosis after DCB.ResultsA total of 117 patients were included. During 1-year follow-up, 19 cases (16.2%) of restenosis were detected. Five of these patients (4.3% of total included patients) were readmitted for symptomatic ischemia. No deaths or amputations occurred. Baseline NLR in patients with restenosis was higher than that in patients without restenosis (2.4 (2.1, 3.4) vs. 1.8 (1.3, 2.3), P &lt; 0.001). Logistic univariate and multivariate analysis showed that baseline hs-CRP level (OR = 1.10, 95%CI: 1.05–1.34), lesion length (OR = 1.04, 95%CI: 1.02–1.27), use of rivaroxaban (OR = 1.08, 95%CI: 1.05–1.39), NLR (OR = 1.47, 95%CI: 1.13–2.48), LDL-C level (OR = 1.25, 95%CI: 1.05–1.52), and diabetes (OR = 1.25, 95%CI: 1.05–1.52) = 1.18, 95%CI: 1.06–1.66) were predictors of restenosis.ConclusionBaseline NLR before DCB can predict the risk of restenosis after surgery.
Early Results of a Novel Hybrid Prosthesis for Treatment of Acute Aortic Dissection Type A With Distal Anastomosis Line Beyond Aortic Arch Zone Zero
Authors: Mehdiani Arash , Sugimura Yukiharu , Wollgarten Louise , Immohr Moritz Benjamin , Bauer Sebastian , Schelzig Hubert , Wagenhäuser Markus Udo , Antoch Gerald , Lichtenberg Artur , Akhyari Payam 
Published: July 2022

IntroductionAcute aortic dissection type A (AADA) is associated with high perioperative morbidity and mortality. A novel non-covered hybrid prosthesis (Ascyrus Medical Dissection Stent (AMDS) Hybrid Prosthesis, Cryolife/Jotec, Hechingen, Germany) can be easily implanted to stabilize the true lumen (TL), improve remodeling, and preserve organ perfusion. Although developed for implantation in aortic zone 0, occasionally, partial replacement of the aortic arch and further distal implantation of AMDS may appear favorable. Implantation of AMDS with anastomosis line beyond zone 0 has not been described yet.Materials and MethodsBetween 08/2019 and 12/2020, a total of n = 97 patients were treated due to AADA at a single University hospital. Of those, n = 28 received an AMDS hybrid prosthesis, of whom in eight patients, due to intraoperative finding the distal anastomosis line was placed distal to the brachiocephalic trunk. Three patients had AMDS implantation in zone I and four were treated by implantation of the prostheses in zone II, and one patient had the implantation performed in zone III. Clinical outcome and the development of a proportional area of TL and false lumen (FL) at defined levels of the thoracic aorta were analyzed.ResultsNone of the surviving patients (87.5%) showed signs of clinical malperfusion (i.e., stroke, spinal cord injury, and need for dialysis). A postoperative CT scan showed an open TL in all patients. The proportion of TL with respect to total aortic diameter (TL+FL) was postoperatively significantly higher in zone III (p = 0.016) and at the level of T11 (p = 0.009). The mean area of TL+FL was comparable between pre- and postoperative CT-scan (p = n.s.). One patient with preoperative resuscitation died of multiple organ failure on extracorporeal life support on postoperative day 3.ConclusionImplantation of AMDS can be safely performed in patients who need partial replacement of the aortic arch beyond zone 0. The advantages of the AMDS can be combined with those of the total arch repair (remodeling of the arch and prevention of TL collapse) without the possible disadvantages (risk of spinal cord injury).
Abnormal Diastolic Hemodynamic Forces: A Link Between Right Ventricular Wall Motion, Intracardiac Flow, and Pulmonary Regurgitation in Repaired Tetralogy of Fallot
Authors: Loke Yue-Hin , Capuano Francesco , Kollar Sarah , Cibis Merih , Kitslaar Pieter , Balaras Elias , Reiber Johan H. C. , Pedrizzetti Gianni , Olivieri Laura 
Published: July 2022

Background and ObjectiveThe effect of chronic pulmonary regurgitation (PR) on right ventricular (RV) dysfunction in repaired Tetralogy of Fallot (RTOF) patients is well recognized by cardiac magnetic resonance (CMR). However, the link between RV wall motion, intracardiac flow and PR has not been established. Hemodynamic force (HDF) represents the global force exchanged between intracardiac blood volume and endocardium, measurable by 4D flow or by a novel mathematical model of wall motion. In our study, we used this novel methodology to derive HDF in a cohort of RTOF patients, exclusively using routine CMR imaging.MethodsRTOF patients and controls with CMR imaging were retrospectively included. Three-dimensional (3D) models of RV were segmented, including RV outflow tract (RVOT). Feature-tracking software (QStrain 2.0, Medis Medical Imaging Systems, Leiden, Netherlands) captured endocardial contours from long/short-axis cine and used to reconstruct RV wall motion. A global HDF vector was computed from the moving surface, then decomposed into amplitude/impulse of three directional components based on reference (Apical-to-Basal, Septal-to-Free Wall and Diaphragm-to-RVOT direction). HDF were compared and correlated against CMR and exercise stress test parameters. A subset of RTOF patients had 4D flow that was used to derive vorticity (for correlation) and HDF (for comparison against cine method).Results68 RTOF patients and 20 controls were included. RTOF patients had increased diastolic HDF amplitude in all three directions (p&lt;0.05). PR% correlated with Diaphragm-RVOT HDF amplitude/impulse (r = 0.578, p&lt;0.0001, r = 0.508, p &lt; 0.0001, respectively). RV ejection fraction modestly correlated with global HDF amplitude (r = 0.2916, p = 0.031). VO2–max correlated with Septal-to-Free Wall HDF impulse (r = 0.536, p = 0.007). Diaphragm-to-RVOT HDF correlated with RVOT vorticity (r = 0.4997, p = 0.001). There was no significant measurement bias between Cine-derived HDF and 4D flow-derived HDF by Bland-Altman analysis.ConclusionRTOF patients have abnormal diastolic HDF that is correlated to PR, RV function, exercise capacity and vorticity. HDF can be derived from conventional cine, and is a potential link between RV wall motion and intracardiac flow from PR in RTOF patients.
Normal Echocardiographic Reference Values of the Right Ventricular to Left Ventricular Endsystolic Diameter Ratio and the Left Ventricular Endsystolic Eccentricity Index in Healthy Children and in Children With Pulmonary Hypertension
Authors: Schweintzger Sabrina , Kurath-Koller Stefan , Burmas Ante , Grangl Gernot , Fandl Andrea , Noessler Nathalie , Avian Alexander , Gamillscheg Andreas , Chouvarine Philippe , Hansmann Georg , Koestenberger Martin 
Published: July 2022

BackgroundAn accurate assessment of the right and left ventricle and their interaction is important in pediatric pulmonary hypertension (PH). Our objective was to provide normal reference values for the right ventricular to left ventricular endsystolic (RV/LVes) ratio and the LV endsystolic eccentricity index (LVes EI) in healthy children and in children with PH.MethodsWe conducted an echocardiographic study in 769 healthy children (median age: 3.36 years; range: 1 day—18 years) and validated abnormal values in 44 children with PH (median age: 2.1 years; range: 0.1 months—17.7 years). We determined the effects of gender, age, body length, body weight, and body surface area (BSA) on RV/LVes ratio and LVes EI values. The RV/LVes ratio and LVes EI were measured from the parasternal short axis view between papillary muscle from the endocardial to endocardial surfaces.ResultsBoth, the RV/LVes ratio and the LVes EI were highly age-dependent: (i) neonates RV/LVes ratio [median 0.83 (range 0.53–1.37)], LVes EI [1.21 (0.92–1.45)]; (ii) 12–24 months old: RV/LVes ratio: [0.55 (0.35–0.80)], LVes EI: [1.0 (0.88–1.13)]; iii) 18th year of life RV/LVes ratio: [0.53 (0.32–0.74)], LVes EI: [1.0 (0.97–1.07)]. Healthy neonates had high LVes EI and RV/LVes ratios, both gradually decreased within the first year of life and until BSA values of about 0.5 m2, body weight to about 15 kg and body length to about 75 cm, but were almost constant thereafter. Children (&gt;1 year) and adolescents with PH had significantly higher RV/LVes ratio (no PH: median 0.55, IQR 0.49–0.60; PH: 1.02, 0.87–1.26; p &lt; 0.001) and higher LVes EI values (no PH: 1.00, 0.98–1.00; PH: 1.53, 1.26–1.71; p &lt; 0.001) compared to those without PH. To predict the presence of PH in children &gt; 1 year, we found the following best cutoff values: RV/LVes ratio ≥ 0.67 (sensitivity: 1.00, specificity: 0.95) and LVes EI ≥ 1.06 (sensitivity: 1.00, specificity: 0.97).ConclusionWe provide normal echocardiographic reference values of the RV/LVes ratio and LVes EI in healthy children, as well as statistically determined cutoffs for the increased values in children with PH.
Long-Term Treatment With Letrozole in a Boy With Familial Male-Limited Precocious Puberty
Authors: Yuan Xin , Chen Ruimin , Zhang Ying , Yang Xiaohong , Lin Xiangquan 
Published: July 2022

BackgroundThe long-term follow-up in children with familial male-limited precocious puberty (FMPP) who were treated with letrozole, triptorelin, and spironolactone is limited, especially considering the efficiency and safety.ObjectiveWe describe the clinical characteristics and long-term treatment with letrozole on adult height of a boy diagnosed with FMPP, confirmed by analysis of the LHCGR gene.MethodsPhysical examinations, bone age (BA), testosterone, and gonadotropin levels were measured as well as gene sequencing of the proband and parents.ResultsThe boy was referred to the hospital at 3.1 years of age due to peripheral precocious puberty. His height was 116.8cm (+5.1SD) and BA was 9 years. Genetic analysis revealed a patrilineal c.1703C&gt;T.(p.Ala568Val) mutation of the LHCGR gene. After treating with letrozole for 1.6 years, the height according to BA went from -3.52SD to -2.82SD. Triptorelin was added at age 4.7 years based on both the evidence of central puberty and his growth velocity according to BA. During the 6.9 years of treatment, he had a height gain of 51.9cm, and BA increased 5.2 years. At age 10, his present height is 168.7cm (0.05SD) and BA is 14.7 years. No adverse effects of treatment were encountered.ConclusionA patrilineal mutation of the LHCGR gene has been identified in a boy with FMPP. His height is 168.7cm (-0.05SD) which is approaching his adult height after long-term treatment with letrozole, triptorelin, and spironolactone.
Triglyceride Glucose-Body Mass Index and Risk of Incident Type 2 Diabetes Mellitus in Japanese People With Normal Glycemic Level: A Population-Based Longitudinal Cohort Study
Authors: Song Bei , Zhao Xiaofang , Yao Tianci , Lu Weilin , Zhang Hao , Liu Ting , Liu Chengyun , Wang Kun 
Published: July 2022

BackgroundIt has been proved that triglyceride glucose-body mass index (TyG-BMI) is a readily available and clinically significant indicator of insulin resistance (IR). Nevertheless, the association between TyG-BMI and incident Type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to study the relationship between TyG-BMI and T2DM and explore the predictive characteristics of TyG-BMI.MethodsOur study was conducted as a longitudinal cohort study. 8,430 men and 7,034 women were enrolled and analyzed. They were both non-diabetic subjects with normal glycemic levels. Follow-up lasted for 13 years, from 1994 to 2016. To make the number of TyG-BMI in each group similar, the subjects were divided into four groups with 3866 subjects in each group.ResultsDuring the 13-year follow-up period, 373 subjects were diagnosed with incident T2DM. Our multivariate Cox regression analysis revealed that TyG-BMI was an independent predictor of incident T2DM. In addition, our research identified four specific groups, young people (18-44 years old), women, the non-hypertensive population and non-drinkers were at significantly higher risk of developing TyG-BMI-related diabetes (P-interaction&lt; 0.05). The best threshold TyG-BMI for predicting incident T2DM was 197.2987 (area under the curve 0.7738).ConclusionsOur longitudinal cohort study demonstrated the positive correlation between baseline TyG-BMI and risk of incident T2DM in Japanese with normal glycemic levels, and this risk was significantly higher in the young people, women, the non-hypertensive population and non-drinkers.
Effect of Levothyroxine on Older Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis
Authors: Zhao Chunyan , Wang Yueqi , Xiao Liu , Li Lin 
Published: July 2022

BackgroundSubclinical hypothyroidism (SCH) is usually treated with levothyroxine, but there is controversy as to whether SCH should be treated, especially for older patients. The aim of the systematic review and meta-analysis was to evaluate whether levothyroxine has a beneficial or harmful effect on older patients with SCH.MethodsDatabases including PubMed, Embase, Cochrane Library, Web of Science, Wanfang, Weipu and China National Knowledge Infrastructure were searched from inception until December 21, 2021. Subjects must be diagnosed with SCH, and older than or equal to 60 years of age. Interventions should be thyroid hormone therapy (e.g. levothyroxine). The literature was independently screened by 2 researchers. Statistical analysis was performed using RevMan5.3 software.ResultsA total of 13 articles were included. Meta-analysis results showed that in older SCH patients, levothyroxine can significantly reduce cholesterol (TC) (p &lt; 0.00001), triglyceride (TG) (p &lt; 0.00001), low-density lipoprotein cholesterol (LDL-C) (p = 0.03) and apolipoprotein B (ApoB) (p &lt; 0.00001). In addition, levothyroxine had no significant effect on bone mineral density, fatigue, hypothyroidism symptoms, quality of life, BMI, cognitive function, depression, blood pressure, etc. in older SCH patients, and also did not significantly increase the incidence of adverse events.ConclusionsAmong older SCH patients, levothyroxine treatment may reduce TC, TG, LDL-C, and ApoB.