bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluación del rendimiento en consumo de combustible y emisiones contaminantes del vehículo segmento A, aplicando la simulación de ciclo IM 240 en la ciudad de Riobamba.
Authors: Molina López Jorge Oswaldo , Solís Santamaria Javier Milton , Masaquiza Yanzapanta Ángel Guillermo , Rocha Hoyos Juan Carlos 
Published: August 2022

En base a estudios previos de emisiones de gases a nivel mundial, partió el objetivo de análisis de los factores de emisión originados por los combustibles Super y Extra en un vehículo de segmento A; al cual se le someterá a pruebas en un dinamómetro, bajó las características de simulación de conducción IM240, también se utilizó el analizador de gases MAHA, y un recipiente presurizado para evaluar el rendimiento bajo la condición de altura de 2754 msnm de la ciudad de Riobamba. Una vez estimados los factores de emisión de CO, HC y NOx para cada combustible (g/km) se realizó el análisis estadístico mediante el software STATGRAPHICS, donde con el análisis de varianza (ANOVA) y el procedimiento de diferencia mínima significativa (LSD) de Fisher. Se determinó que existe una diferencia representativa en la generación de CO para ambos combustibles, pero con un comportamiento similar para HC Y NOx con un nivel de confianza del 95%. Además, el rendimiento del líquido operante es más eficiente con el combustible Super, con un 11% adicional en su autonomía.
El comportamiento de los empleados públicos de Guayaquil incide en la satisfacción de los usuarios
Authors: Carrera López Jean Steve , Bedor Vargas Deyton Darío , Huacón Arévalo Manuel Orlando 
Published: August 2022

Introducción: La velocidad de los cambios tecnológicos y la globalización hace que la cantidad de información cada día sea mayor, con ello las necesidades de las personas, por lo cual sus exigencias son mayores en cuanto a la atención requerida para algún servicio. Por esa razón las entidades públicas deben velar porque el personal cuente con las competencias para una atención de calidad. Por su parte, el Estado, se han encargo de generar las leyes y normativas para garantizar que los procesos y la atención a los usuarios sea eficiente. No obstante, las instituciones públicas de Guayaquil aún requieren ajustes a fin de evitar esta situación y es allí donde radica la importancia de esta investigación, ya que, a través de las diferentes posiciones de los autores, se pudo internalizar sobre los puntos más resaltantes sobre los usuarios, los servidores públicos, las leyes, normas y procedimientos existente en Ecuador. Se usó una metodología de tipo documental, basada en el diseño bibliográfico. Con ello, se evidenciar que en Guayaquil se hace indispensable que las autoridades no solo se enfoquen en generar leyes, sino que la debe velar por el cumplimiento de sus procesos administrativos siguiendo las pautas legales existentes para ello.
Gamificación: estrategia que motiva el aprendizaje en entornos virtuales de los niños del nivel preparatoria
Authors: Quingaluisa Sasintuña Jessica Alexandra , Mena Hernández Liliana del Rocío 
Published: August 2022

Introducción. Por la situación pandémica mundial que se atraviesa se considera aplicar la gamificación como proceso de aprendizaje en entornos virtuales, puesto que se introduce el juego en el ámbito educativo, motivo por el cual el juego trabajo es la metodología que se emplea en edades tempranas para lograr experiencias significativas y la vez mejorar la práctica docente, como Objetivo. de esta investigación es Implementar la gamificación para el desarrollo de la motivación por aprender en entornos virtuales de los niños del nivel preparatoria de la Unidad Educativa “Salcedo”. Metodología. En tal virtud la investigación se basa en la modalidad cuantitativa, con alcance descriptivo y explicativo, partiendo del análisis de datos recopilados para explicar las características y propiedades del grupo de estudio. El método para utilizar es de nivel teórico: análisis y síntesis, hipotético deductivo y del nivel empírico: la observación directa (zoom) a niños de cinco años y encuesta en línea a sus representantes. Resultados como resultados se obtuvo la confiabilidad del instrumento con un alfa de Cronbach de ,810 y en la prueba de normalidad un valor de 0.00 la misma que rechaza la hipótesis nula y acepta la hipótesis alterna de manera altamente significante Conclusiones se puede concluir que la aplicación de la gamificación si motivo al estudiante a tener un aprendizaje significativo en un tiempo reducido.
DIAGNOSIS KESALAHAN PESERTA DIDIK DALAM MENYELESAIKAN SOAL MATEMATIKA POKOK BAHASAN LINGKARAN KELAS VIII SMP NEGERI 7 KOTA BENGKULU
Authors: Muniroh Fauziatul , Yensy Nurul Astuty , Muchlis Effie Efrida , Siagian Teddy Alfra 
Published: August 2022

Penelitian ini merupakan penelitian deskriptif untuk mengetahui kesalahan apa saja yang dilakukan peserta didik dalam menyelesaikan soal matematika pokok bahasan lingkaran kelas VIII SMPN 7 Kota Bengkulu Tahun ajaran 2019/2020. Sebanyak 29 peserta didik kelas VIII C dipilih sebagai subjek penelitian ini. Instrumen dan teknik pengumpulan data yang digunakan dalam penelitian ini adalah lembar tes. Hasil penelitian menunjukkan bahwa bentuk kesalahan yang dilakukan peserta didik dalam menyelesaikan soal tentang lingkaran yaitu: a) kesalahan menentukan unsur juring lingkaran dilakukan oleh 65,52% peserta didik, b) kesalahan menentukan tali busur lingkaran dilakukan oleh 20,69% peserta didik, c) kesalahan dalam menentukan konsep hubungan sudut pusat dan sudut keliling yang menghadap busur yang sama dilakukan oleh 17,24% peserta didik, d) kesalahan dalam operasi bilangan bulat dilakukan oleh 31,03% peserta didik, e) kesalahan dalam menentukan rumus panjang lintasan pada roda yang berputar dilakukan oleh 31,03% peserta didik, f) kesalahan dalam menentukan rumus keliling atau luas lingkaran dilakukan oleh 24,14% peserta didik, g) kesalahan dalam menggunakan rumus untuk menentukan luas tembereng dilakukan oleh 37,93% peserta didik, dan h) kesalahan dalam menggunakan konsep untuk menghitung keliling daerah yang diarsir dilakukan oleh 13,79% peserta didik.
2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside improves female ovarian aging
Authors: Lin Hung-Yun , Yang Yung-Ning , Chen Yi-Fong , Huang Tung-Yung , Crawford Dana R. , Chuang Hui-Yu , Chin Yu-Tang , Chu Hung-Ru , Li Zi-Lin , Shih Ya-Jung , Chen Yi-Ru , Yang Yu-Chen S. H. , Ho Yih , Davis Paul J. , Whang-Peng Jacqueline , Wang Kuan 
Published: August 2022

Reduced fertility associated with normal aging may reflect the over-maturity of oocytes. It is increasingly important to reduce aging-induced infertility since recent trends show people marrying at later ages. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG), a polyphenol extracted from Polygonum multiflorum, has been reported to have anti-inflammatory and anti-aging properties. To evaluate whether THSG can reduce aging-related ovarian damage in a female mouse model of aging, THSG was administered by gavage at a dose of 10 mg/kg twice weekly, starting at 4 weeks of age in a group of young mice. In addition, the effect of THSG in a group of aged mice was also studied in mice starting at 24 weeks of age. The number of oocytes in the THSG-fed group was higher than in the untreated control group. Although the percentage of secondary polar bodies (PB2) decreased during aging in the THSG-fed group, it decreased much more slowly than in the age-matched control group. THSG administration increased the quality of ovaries in young mice becoming aged. Western blotting analyses also indicated that CYP19, PR-B, and ER-β expressions were significantly increased in 36-week-old mice. THSG also increased oocyte numbers in aged mice compared to mice without THSG fed. Studies of qPCR and immunohistochemistry (IHC) analyses of ovaries in the aged mice groups were conducted. THSG increased gene expression of anti-Müllerian hormone (AMH), a biomarker of oocyte number, and protein accumulation in 40-week-old mice. THSG increased the expression of pgc1α and atp6, mitochondrial biogenesis-related genes, and their protein expression. THSG also attenuated the fading rate of CYP11a and CYP19 associated with sex hormone synthesis. And THSG maintains a high level of ER-β expression, thereby enhancing the sensitivity of estrogen. Our findings indicated that THSG increased or extended gene expression involved in ovarian maintenance and rejuvenation in young and aged mice. On the other hand, THSG treatments significantly maintained oocyte quantity and quality in both groups of young and aged mice compared to each age-matched control group. In conclusion, THSG can delay aging-related menopause, and the antioxidant properties of THSG may make it suitable for preventing aging-induced infertility.
A holistic carrier-bound immobilization approach for unspecific peroxygenase
Authors: De Santis Piera , Petrovai Noémi , Meyer Lars-Erik , Hobisch Markus , Kara Selin 
Published: August 2022

Unspecific peroxygenases (UPOs) are among the most studied enzymes in the last decade and their well-deserved fame owes to the enzyme’s ability of catalyzing the regio- and stereospecific hydroxylation of non-activated C–H bonds at the only expense of H2O2. This leads to more direct routes for the synthesis of different chiral compounds as well as to easier oxyfunctionalization of complex molecules. Unfortunately, due to the high sensitivity towards the process conditions, UPOs’ application at industrial level has been hampered until now. However, this challenge can be overcome by enzyme immobilization, a valid strategy that has been proven to give several benefits. Within this article, we present three different immobilization procedures suitable for UPOs and two of them led to very promising results. The immobilized enzyme, indeed, shows longer stability and increased robustness to reaction conditions. The immobilized enzyme half-life time is 15-fold higher than for the free AaeUPO PaDa-I and no enzyme deactivation occurred when incubated in organic media for 120 h. Moreover, AaeUPO PaDa-I is proved to be recycled and reused up to 7 times when immobilized.
A nitrogen-doped graphene-supported nickel-single-atom catalyst in the flow cell meets the industrial criteria of carbon dioxide reduction reaction to carbon monoxide
Authors: Lu Yi-Hsuan , Tsai Hsin-Jung , Huang Wen-Yang , Lee Tsung-Ju , Lin Zih-Yi , Hsu Shao-Hui , Hung Sung-Fu 
Published: August 2022

Carbon dioxide reduction reaction (CO2RR) is a promising approach to accomplishing net zero CO2 emissions. Among CO2RR catalysts, nitrogen-doped graphene-supported single-atom catalysts show a remarkable conversion rate from CO2 to CO; however, the low production amount has been limited using the conversion H cell, hindering its industrial development. In this work, we synthesize a nitrogen-doped graphene-supported nickel-single-atom catalyst and conduct CO2RR in a flow cell, exhibiting a CO2-to-CO Faradaic efficiency of 96% and a partial current density of 144 mA cm−2. It can also achieve the highest partial current density of 204 mA cm−2 with a turnover frequency of 7,852 h−1. According to the techno-economic analysis, these preeminent activities meet the industrial criteria (Faradaic efficiency &gt;60% and partial current density &gt;100 mA cm−2). This activity enhancement using a flow system can significantly accelerate net-zero CO2 emission realization.
Prognostic significance of myocardial salvage assessed by cardiac magnetic resonance in reperfused ST-segment elevation myocardial infarction
Authors: Li Yunling , Wang Guokun , Wang Xueying , Li Ye , Zhao Yanming , Gu Xia , Xu Bing , Cui Jinjin , Wang Xuedong , Sun Yong , Liu Shengliang , Yu Bo 
Published: August 2022

AimsMyocardial salvage index (MSI) is attracting increasing attention for predicting prognosis in acute myocardial infarction (AMI); however, the evaluation of MSI is mainly based on contrast agent-dependent cardiac magnetic resonance (CMR) scanning sequences. This study aims to investigate the prognostic value of MSI in reperfused ST-segment elevation myocardial infarction (STEMI) through the contrast agent-free CMR technique.Methods and resultsNighty-two patients with acute STEMI, who underwent CMR after primary percutaneous coronary intervention (PPCI), were finally enrolled. Patients were subcategorized into two groups according to median MSI. T1 and T2 mapping were conducted for measuring infarct size (IS) and area at risk (AAR). IS was significantly larger in &lt; median MSI group than ≥ median MSI group (P &lt; 0.001). AAR between the two groups showed no obvious differences (P = 0.108). Left ventricular ejection fraction (LVEF) was lower in &lt; median MSI group than ≥ median MSI group (P = 0.014). There was an obvious inverse correlation between MSI and reperfusion time (R = –0.440, P &lt; 0.001) and a strong inverse correlation between MSI and IS (R = –0.716, P = 0.011). As for the relationship LVEF, MSI showed positive but weak correlation (R = 0.2265, P &lt; 0.001). Over a median follow-up period of 263 (227–238) days, prevalence of MACEs was significantly higher in the &lt; median MSI group [HR: 0.15 (0.04–0.62); Log-rank P = 0.008]. The univariate Cox regression analysis revealed that LVEF, IS, and MSI were significant predictors for major adverse cardiovascular events (MACEs) (all P &lt; 0.05). In the stepwise multivariate Cox regression analysis, LVEF and MSI were identified as independent parameters for predicting MACEs (both P &lt; 0.05). In the receiver-operating characteristic analysis, LVEF, IS, and MSI showed prognostic value in predicting MACEs with AUCs of 0.809, 0.779, and 0.896, respectively, all (P &lt; 0.05). A combination of MSI with LVEF showed the strongest prognostic value of MACEs (AUC: 0.901, sensitivity: 77.78%, specificity: 98.80%, P &lt; 0.001). Delong’s test showed that the combination of LVEF with MSI had an incremental value than LVEF itself in predicting MACEs (P = 0.026).ConclusionContrast agent-free CMR technique provides a reliable evaluation of MSI, which contributes to assessing the efficacy of reperfusion therapy and predicting the occurrence of MACEs.
Foundations for fairness in digital health apps
Authors: Buda Teodora Sandra , Guerreiro João , Omana Iglesias Jesus , Castillo Carlos , Smith Oliver , Matic Aleksandar 
Published: August 2022

Digital mental health applications promise scalable and cost-effective solutions to mitigate the gap between the demand and supply of mental healthcare services. However, very little attention is paid on differential impact and potential discrimination in digital mental health services with respect to different sensitive user groups (e.g., race, age, gender, ethnicity, socio-economic status) as the extant literature as well as the market lack the corresponding evidence. In this paper, we outline a 7-step model to assess algorithmic discrimination in digital mental health services, focusing on algorithmic bias assessment and differential impact. We conduct a pilot analysis with 610 users of the model applied on a digital wellbeing service called Foundations that incorporates a rich set of 150 proposed activities designed to increase wellbeing and reduce stress. We further apply the 7-step model on the evaluation of two algorithms that could extend the current service: monitoring step-up model, and a popularity-based activities recommender system. This study applies an algorithmic fairness analysis framework for digital mental health and explores differences in the outcome metrics for the interventions, monitoring model, and recommender engine for the users of different age, gender, type of work, country of residence, employment status and monthly income.Systematic Review Registration: The study with main hypotheses is registered at: https://osf.io/hvtf8
Effect of laparoscopic cystectomy on ovarian reserve in patients with ovarian cyst
Authors: Mansouri Ghazal , Safinataj Maryam , Shahesmaeili Armita , Allahqoli Leila , Salehiniya Hamid , Alkatout Ibrahim 
Published: August 2022

ObjectiveThis study aimed to evaluate the effect of laparoscopic cystectomy on ovarian reserve in patients with ovarian cysts.Material and methodsThis prospective study was performed on 113 women with ovarian cysts in a tertiary referral teaching hospital. All patients underwent laparoscopic cystectomy. Serum levels of antimüllerian hormone (AMH) were measured pre-and, 3 months postoperatively. The primary outcome of the study was to assess the effect of laparoscopic cystectomy on ovarian reserve based on alterations in serum AMH levels. The secondary outcome of the present study was to evaluate the impact of the number of cauterizations, size and type of cysts, bilaterality (bilateral or unilateral), age, and body mass index (BMI) on the ovarian reserve after laparoscopic excision.ResultsLaparoscopic cystectomy reduced the serum AMH levels preoperatively (1.32 ± 4.48 ng/ml) to postoperatively (3.2 ± 1.93 ng/ml) and the difference (- 1.28 ng/ml) was statistically different (0.001 &gt;P). There was a negative significant relationship between the number of cauterizations used and postoperative serum AMH levels (p ≤ 0.001). There was a significant relationship between the location (p ≤ 0.01), type of cyst (p ≤ 0.001) and the serum AMH levels reduction.ConclusionThe number of cauterizations used during surgery, the type of cyst, and bilaterality can affect AMH levels that need to be addressed.
Prevalence of central obesity and associated factors in Ethiopia: A systematic review and meta-analysis
Authors: Tegegne Kirubel Dagnaw , Wagaw Gebeyaw Biset , Gebeyehu Natnael Atnafu , Yirdaw Lehulu Tilahun , Shewangashaw Nathan Estifanos , Mekonen Nigusie Abebaw , Kassaw Mesfin Wudu 
Published: August 2022

IntroductionObesity is a global public health concern that is now on the rise, especially in low- and middle-income nations. Despite the fact that there are several studies reporting the prevalence of central obesity among adults in Ethiopia, there is a lack of a systematic review and meta-analysis synthesizing the existing observational studies. Therefore, this systematic review and meta-analysis aimed to determine the prevalence of central obesity and its associated factors in Ethiopia.MethodsOnline libraries such as PubMed, Google Scholar, Scopus, Science Direct, and Addis Ababa University were searched. Data were extracted using Microsoft Excel and analyzed using STATA statistical software (v. 16). Forest plots, Begg’s rank test, and Egger’s regression test were all used to check for publication bias. To look for heterogeneity, I2 was computed, and an overall estimated analysis was carried out. Subgroup analysis was done by region and study setting. In addition, the pooled odds ratio for related covariates was calculated.ResultsOut of 685 studies assessed, 20 met our criteria and were included in the study. A total of 12,603 people were included in the study. The prevalence of central obesity was estimated to be 37.31% [95% confidence interval (CI): 29.55–45.07]. According to subgroup analysis by study region and setting, the highest prevalence was observed in the Dire Dawa region (61.27%) and community-based studies (41.83%), respectively. Being a woman (AOR = 6.93; 95% CI: 3.02–10.85), having better socioeconomic class (AOR = 5.45; 95% CI: 0.56–10.34), being of age 55 and above (AOR = 5.23; 95% CI: 2.37–8.09), being physically inactive (AOR = 1.80; 95% CI: 1.37–2.24), being overweight (AOR = 4.00; 95% CI: 2.58–5.41), being obese (AOR = 6.82; 95% CI: 2.21–11.43), and having hypertension (AOR = 3.84; 95% CI: 1.29–6.40) were the factors associated with central obesity.ConclusionThe prevalence of central obesity was high in Ethiopia. Being a woman, having a higher socioeconomic class, being older, being physically inactive, being overweight or obese, and having hypertension were all associated. Therefore, it is vital for the government and health organizations to design and implement preventive measures like early detection, close monitoring, and positive reversal of central obesity in all patients and the general population. High-quality investigations on the prevalence of central obesity in the Ethiopian people are required to better understand the status of central obesity in Ethiopia.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier: CRD42022329234.
Effect of the maximum thickness of a composite airfoil on the performance of a helical axial-flow gas-liquid multiphase pump
Authors: Han Wei , Nan Haozhi , Ju Pengpeng , Zhang Huan , Li Fengqing , Li Rennian 
Published: August 2022

Operating efficiency and reliability are major problems that restrict gas-liquid multiphase pumps, which are core pieces of equipment used in deep-sea oil and gas exploration and transportation. In this paper, a 100-20x helical axial-flow gas-liquid pump is taken as the research object. The Euler multiphase flow model and SST k-ω turbulent model are used to model the multiphase pump. By exploring the airfoil composite position and the maximum thickness composite scheme, a mathematical model for the head coefficient and efficiency of the multiphase pump with respect to the relative thickness is established, and the external and internal flow characteristics of the modified multiphase pump are analyzed. We explore the influence of the composite position and the maximum thickness variation law of the composite airfoil on the performance of the mixed pump and determine the final airfoil composite scheme. We found that a change in the maximum thickness of the composite airfoil gives the external curve of the multiphase pump a “hump"-like characteristic, which shows that the head coefficient and efficiency increase first and then decrease with the increase in the maximum thickness of the composite airfoil. When the composite position is in the middle of the airfoil, the airfoil maximum thickness is 1.25 mm and the gas-phase volume fraction is 70%. Moreover, the head coefficient and efficiency of the multiphase pump reach their maximum values; the head coefficient and efficiency increase by 2.4% and 1.16%, respectively, compared with the basic model.
Establishment of a prognostic ferroptosis- and immune-related long noncoding RNAs profile in kidney renal clear cell carcinoma
Authors: Han Zhijun , Wang Hao , Liu Yafei , Xing Xiao-Liang 
Published: August 2022

Background: Ferroptosis and immunity are novel treatments that target several cancers, including kidney renal clear cell carcinoma (KIRC). Long noncoding RNAs (lncRNAs) are an important class of gene expression regulators that play fundamental roles in the regulation of ferroptosis and immunity. We aimed to identify ferroptosis- and immune-related lncRNAs as biomarkers in patients with KIRC.Methods: Corresponding data for each patient with KIRC were obtained from The Cancer Genome Atlas (TCGA) database. Univariate and multivariate Cox regression analyses were used to identify candidate biomarkers followed by least absolute shrinkage and selection operator (LASSO) regression analyses, weighted gene coexpression network analysis (WGCANA), and gene set enrichment analysis (GSEA).Results: Three ferroptosis- and immune-related differentially expressed lncRNAs (FI-DELs) (AC124854.1, LINC02609, and ZNF503-AS2) were markedly and independently correlated with the overall survival (OS) of patients with KIRC. The area under the curve (AUC) value of the prognostic model in the entire group using the three FI-DELs was &gt; 0.70. The sensitivity and specificity of the diagnostic model using the three FI-DELs were 0.8586 and 0.9583, respectively.Conclusion: The present study found that AC124854.1, LINC02609, and ZNF503-AS2 were considerably and independently correlated with the OS of patients with KIRC, suggesting that the three FI-DELs could be used as prognostic and diagnostic biomarkers for patients with KIRC.