bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interference by macroprolactin in assays for prolactin: will the In Vitro Diagnostics Regulation lead to a solution at last?
Authors: Fahie-Wilson Michael N. , Cobbaert Christa M. , Horvath Andrea R. , Smith Thomas P. 
Published: June 2022

Abstract
Cross reactivity with high molecular weight complexes of prolactin known as macroprolactin is a common cause of positive interference in assays for serum prolactin. All prolactin assays currently available are affected with 5–25% of results indicating hyperprolactinaemia falsely elevated due to macroprolactinaemia – hyperprolactinaemia due to macroprolactin with normal concentrations of bioactive monomeric prolactin. Macroprolactinaemia has no pathological significance but, if it is not recognised as the cause, the apparent hyperprolactinaemia can lead to clinical confusion, unnecessary further investigations, inappropriate treatment and waste of healthcare resources. Macroprolactinaemia cannot be distinguished from true hyperprolactinaemia on clinical grounds alone but can be detected by a simple laboratory test based on the precipitation of macroprolactin with polyethylene glycol. Laboratory screening of all cases of hyperprolactinaemia to exclude macroprolactinaemia has been advised as best practice but has not been implemented universally and reports of clinical confusion caused by macroprolactinaemia continue to appear in the literature. Information provided by manufacturers to users of assays for prolactin regarding interference by macroprolactin is absent or inadequate and does not comply with the European Union Regulation covering in vitro diagnostic medical devices (IVDR). As the IVDR is implemented notified bodies should insist that manufacturers of assays for serum prolactin comply with the regulations by informing users that macroprolactin is a source of interference which may have untoward clinical consequences and by providing an estimate of the magnitude of the interference and a means of detecting macroprolactinaemia. Laboratories should institute a policy for excluding macroprolactinaemia in all cases of hyperprolactinaemia.
Applying spline-based phase analysis to macroeconomic dynamics
Authors: Lyudmila Gadasina , Lyudmila Vyunenko 
Published: June 2022

Abstract
The article uses spline-based phase analysis to study the dynamics of a time series of low-frequency data on the values of a certain economic indicator. The approach includes two stages. At the first stage, the original series is approximated by a smooth twice-differentiable function. Natural cubic splines are used as an approximating function

y

y

. Such splines have the smallest curvature over the observation interval compared to other possible functions that satisfy the choice criterion. At the second stage, a phase trajectory is constructed in

(

t
,
y
,
y
′

)

\left(t,y,y^{\prime} )

-space, corresponding to the original time series, and a phase shadow as a projection of the phase trajectory onto the

(

y
,
y
′

)

(y,y^{\prime} )

-plane. The approach is applied to the values of GDP indicators for the G7 countries. The interrelation between phase shadow loops and cycles of economic indicators evolution is shown. The study also discusses the features, limitations and prospects for the use of spline-based phase analysis.
Probiotic administration enhanced antitrypanosomal effects of diminazene aceturate in dogs experimentally infected with Trypanosoma brucei brucei
Authors: Kolawole Bamidele Jonathan , Nwoha Rosemary Ijeoma Ogechi , Erin Juwon Pius , Orakpoghenor Ochuko 
Published: June 2022

Abstract

Objectives
This study demonstrated the enhancing actions of probiotic on the antitrypanosomal effects of diminazene aceturate in dogs experimentally infected with Trypanosoma brucei brucei.

Methods
Twenty (20) apparently healthy adult local dogs of both sexes were randomly divided into five groups each containing four dogs. Group I were uninfected and untreated while groups III, IV and V were infected. Groups II, III, IV and V were administered multispecies probiotic (MSP) and/or diminazene aceturate (DA). Parasitaemia was determined, clinical signs recorded and blood collected for haematology.

Results
Results revealed T. b. brucei prepatent periods of 4.75 ± 0.25, (4–5) days and significant decrease of parasitaemia, clinical signs and mortality in groups IV and V compared to group III. Mortalities of 100% (group III), 25% (group IV) and 0% (group V) were recorded. Mean packed cells volume, haemoglobin concentration and red blood cells count showed no significant difference in groups I, II, and V, but were significantly decreased in groups III and IV post-treatment.

Conclusions
The administration of MSP to infected dogs enhanced the antitrypanosomal effects of diminazene aceturate.
A history of the LBK in the central Polish lowlands
Authors: Whittle Alasdair , Marciniak Arkadiusz , Pyzel Joanna , Krueger Marta , Lisowski Mikolaj , Ramsey Christopher Bronk , Dunbar Elaine , Barclay Alistair , Bayliss Alex , Gaydarska Bisserka 
Published: June 2022

Abstract
A new chronological study of the LBK in the central Polish lowlands shows that it emerged later, lasted for a shorter period, and ended sooner than has been supposed up till now. LBK communities emerged, probably in the middle of the 53rd century cal BC, to form an enclave in the central Polish lowlands, probably as a result of colonisation from loess areas in the south of Poland. Settlement steadily intensified throughout the 52nd century cal BC, reaching its peak at the beginning of Phase III. In the middle of the 51st century cal BC there followed an abrupt decline or collapse, and LBK occupation of the lowlands had probably ended completely by the end of that century. There followed an appreciable gap before the re-emergence of settlement in the form of the Late Band Pottery culture (LBPC), characterised by significantly sparser settlement, changed dwelling structures and contacts with hunter-gatherer groups. A start to the wider task of comparing the situation in the central Polish lowlands with other regional sequences is made principally by reviewing similar formal modelling of a post-LBK hiatus in the Rhineland. Possible factors causing the LBK decline are discussed, including climatic downturn, population boom and bust, warfare, cultural malaise, disease and internal social conflict. None of these is overwhelmingly convincing on its own, and one of the many challenges for continuing research in the Polish lowlands and beyond will be to find further specific evidence to decide which of this range of possibilities is most plausible in specific contexts.
Adsorption of copper ions in water by adipic dihydrazide-modified kapok fibers
Authors: Dalgic Mete Sungur , Palantöken Sinem , Bethke Kevin , Rademann Klaus 
Published: June 2022

Abstract
Kapok fibers (Ceiba pentandra) were modified for the removal of copper ions from aqueous solutions through adsorption. In this fast and facile method, the polysaccharide-like groups of kapok were oxidized with potassium periodate. The novel modification is the loading of the fibers with adipic dihydrazide (ADH) which contain nitrogen and oxygen atoms for heavy metal ion binding. Adsorption experiments have been carried out and analyzed via atom absorption spectroscopy and ultraviolet/visible spectroscopy. In preliminary adsorption experiments, different kapok-based materials have been analyzed on their adsorption capacity and removal efficiency via atom absorption spectroscopy. ADH-modified fibers showed the best results and an increase of copper removal efficiency by 30% in comparison to untreated kapok fibers and superior adsorption capacity compared to kapok fibers loaded with oxalic dihydrazide (ODH). Moreover, the impact of initial concentration and contact time on the adsorption capacity and on the removal efficiency values of the ADH-modified kapok fibers has been studied. Another comparison of the ADH-modified fibers with raw kapok which was cleaned with Milli-Q water, dichloromethane and ethylene glycol showed that the new adsorbents are best suited for copper solutions with concentration values of under 10 mg/L. The heavy metal adsorption experiments were analyzed through both isotherm models Langmuir and Freundlich. The Langmuir model is found to be a suitable model for copper ions. The value of the maximum adsorption capacity is 4.120 mg/g. The ADH-modified kapok fibers were characterized with attenuated total reflection infrared (ATR-IR) spectroscopy, magic-angle spinning nuclear magnetic resonance (MAS-NMR) spectroscopy and scanning electron microscopy (SEM).
Physical Simulation Experiment on the Failure Evolution Process and Failure Mode of Soft Surrounding Rock in a Deep Roadway
Authors: Guo Peng , Fan Jun-qi , Shi Xiao-yan , Wu Qing-xiang 
Published: June 2022

Abstract
Large deformation of surrounding rock is one of the major disasters that cannot be prevented in deep underground engineering. Several arch changes or even landslides may occur if the management is ineffective. In this study, an indoor model experiment is conducted using a similar geotechnical multifunction load simulation device and a surrounding rock strain and displacement monitoring system. The failure evolution process of surrounding rocks and the variation law of displacement and stress of a deep underground roadway under different burial depths are studied. The critical components for preventing large deformations in underground engineering have been identified. Model test results show that the designed deep roadway model loading system can meet the requirements of uniform loading in simulating different deep roadway loads and can satisfactorily realize cascade loading of various surrounding rocks in a deep roadway. The stress and displacement in the surrounding rock can also be efficiently measured with by the designed measuring device. The similarity test of physical simulation indicates that the instability risk of a deep roadway, especially the collapse disaster in the sidewall, is greater with the increase in depth when no support exists. The collapsed area of the surrounding rock gradually increases with the increase in the burial depth of the roadway. In the model test, no evident convergence deformation is observed in the surrounding rock of the roadway when the simulated depth is less than 800 m. The deformation of the sidewall and the arch waist increases with the increase in burial depth.
Neolignans and flavonol glycosides from the leaves of viburnum lutescens blume
Authors: Duc Thien Le , Thi Dung Duong , Phuong Minh Nguyen , Hai Dang Nguyen 
Published: June 2022

Four neolignans, (7S,8S)-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside (1), (7S,8S)-dihydrodehydrodiconiferyl alcohol 9′-O-β-D-glucopyranoside (2), (7S,8R)-5-methoxydihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (3), and (7S,8R)-5-methoxydihydrodehydrodiconiferyl alcohol 9′-O-β-D-glucopyranoside (4) and five flavonol glycosides, kaempferol-3-O-β-D-glucopyranoside (5), kaempferol 3-O-rutinoside (6), kaempferol 3-O-α-L-rhamnopyranosyl (1→6)-β-D-galactopyranoside (7), kaempferol 3-O-β-D-galactopyranoside (8), and quercetin 3-O-β-D-glucopyranoside (9) were isolated from the methanol extract of Viburnum lutescens Blume leaves. Their chemical structures were elucidated by 1D- and 2D-NMR spectra and comparison with those reported in the literature. Compounds 1, 2, and 4 were reported from Viburnum genus for the first time.
Synthesis of chitosan-graft-polyaniline with the conductive potential
Authors: Chau Ngoc Mai , La Thi Thai Ha , Sam Minh Tuan 
Published: June 2022

Chitosan (CS) is one of the most plenteous polymers in nature and gets ubiquitous in many fields such as pharmaceutical and medical industries, wastewater treatment, agriculture, etc.due to its remarkable biodegradability and friendliness to human beings and ecology. Recently, nature-originated conductive materials havebeen gaining more attention than other materials because they can be utilized in reality, while others are difficultto decompose after use. Understandably, polyaniline (PANI), which is one of the prominent conductive polymers with a distinguished conjugated structure, simple synthesis, cost-effectiveness, environmental stability, and conductivity, was grafted with CS (CS-graft-PANI) to produce a copolymer possessing a combination of properties between CS and PANI. Althoughthere have been several researchesrelated to this copolymer, the grafting efficiency and electrical conductivity wererelatively low. Therefore, this paper aims at obtainingahigher efficiency and electrical conductivity of CS-graft-PANI copolymerby systematically adjusting the synthesis parameters including the volume of acid solution to dissolve aniline, initiator concentration, acetic acid concentration to dissolve CS, the initiator methods and dopants. As a result, the best copolymer product reached a graft efficiency of 69.4% and grafting percentage of 78.5% with an electrical conductivity of 7.9610-3 Scm-1. The chemical composition and morphology were determinedby Fourier-transform Infrared Spectroscopy and Scanning Electron Microscope while the thermal characteristic was also carefully detected via Thermogravimetric Analysis.
Replacement of the aortic valve, ascending aorta and arch in a patient with dextrocardia in the context of situs inversus totalis: a case report
Authors: Chernov I. I. , Magomedov G. M. , Kozmin D. Yu. , Enginoev S. T. 
Published: June 2022

The article discusses a rare case of successful replacement of the aortic valve, ascending aorta and arch in a patient with dextrocardia in the context of situs inversus totalis. Situs inversus is a rare variant of normal anatomy in which the major visceral organs are mirrored from their normal positions.
Peningkatan Kreativitas Seni Rupa Anak Melalui Kegiatan Membutsir dengan Media Playdough pada Kelompok B di TK ABA 41 Pambon
Authors: Andriani Putri Novika , Kustiawan Usep , Maningtyas Rosyi Damayani Twinsari 
Published: June 2022

Abstract: The potential for creativity must be carried out from an early age. Because the aspect of art development is one of the important aspects and can affect the development of children in future, the purpose of this research was to determaind the application and improvement of children’s artistic creativity through kneading activities with playdouh media. This study uses classroom action with MC Taggart’s Kemmis cycle model, which consists of two cycles and each cycle consists of two meetings. Based on the research that has been done, it show the results that with the application of the art creativity activities of children can be improved properly.
Abstrak: Mengembangkan potensi kreatif harus dilakukan sejak anak berusia dini, karena aspek perkembangan seni merupakan salah satu aspek yang penting dan dapat mempengaruhi perkembangan anak dimasa selanjutnya. Tujuan dari penelitian ini adalah untuk mengetahui penerapan serta peningkatan kreativitas seni rupa anak melalui kegiatan membutsir dengan media playdough. Penelitian ini menggunakan penelitian tindakan kelas dengan model siklus kemmis MC Taggart, yang terdiri dari dua siklus dan setiap siklusnya terdiri dari dua pertemuan. Berdasarkan dari penelitian yang telah dilakukan menunjukkan hasil bahwa dengan diterapkannya kegiatan membutsir kreativitas seni rupa anak dapat meningkat dengan baik.
Penerapan Kegiatan M3 (Menggambar, Merobek, Menempel) Untuk Meningkatkan Kemampuan Seni Rupa Anak Kelompok B Di Tk Islam Plus Kidz
Authors: Sabillah Lailatus , Kustiawan Usep , Maningtyas Rosyi Damayani Twinsari 
Published: June 2022

Abstract: The M3 (Drawing, Tearing, Sticking) activity is a classroom action research that focuses on efforts to improve children's fine arts skills that combines 3 art activities, namely drawing, tearing, and pasting. The purpose of this study was to improve the artistic ability of children through M3 activities (Drawing, Tearing, Sticking) for children aged 5-6 years. Planning studies using models kurt lewin which in this model there are four components a) Planning, b) Action, c) Observations, and d) Reflection. The development of fine arts skills through M3 activities (Drawing, Tearing, Sticking) had a very good impact on the children of Group B in the Islamic Kindergarten Plus Kidz. Children who were initially hesitant to do drawing, tearing, sticking activities became more confident in carrying out the concept of activities, this was known through the comparison of pre-cycle results which showed a value of 27.27 percent to 81.81 percent in the second cycle.
Abstrak: Kegiatan M3 (Menggambar, Merobek, Menempel) adalah sebuah penelitian mengenai tindakan kelas yang memiliki fokus untuk melihat bagaimana upaya peningkatkan kemampuan seni rupa pada anak yang memadukan 3 kegiatan seni yaitu menggambar, merobek, dan menempel. Tujuan dari dilakukannya penelitian adalah sebagai upaya untuk peningkatan dari kemampuan seni anak dengan adanya kegiatan M3 terhadap anak yang memiliki rentang usia 5 hingga 6 tahun. Perencanaan penelitian yang digunakan adalah model kurt lewin dimana dalam model ini terdapat 4 komponen a) perencanaan atau planing, b) tindakan atau acting, c) pengamatan atau observing, dan d) refleksi atau reflecting. Pengembangan kemampuan seni rupa melalui kegiatan M3 (Menggambar, Merobek, Menempel) berdampak sangat baik bagi anak Kelompok B di TK Islam Plus Kidz. Anak yang semula ragu-ragu untuk melakukan kegitan menggambar, merobek, menempel menjadi lebih percaya diri dalam melaksanakan konsep kegiatan, hal ini diketahui melalui perbandingan hasil prasiklus yang menunjukkan nilai sebesar 27,27 persen menjadi 81,81 persen pada siklus ke 2.
Penerapan Kegiatan Membatik Jumputan untuk Meningkatkan Kemampuan Seni Rupa Anak Kelompok B di TK Dharma Wanita Persatuan 1 Senggreng
Authors: Wisma Rinda Yanuar , Kustiawan Usep , Maningtyas Rosyi Damayani Twinsari 
Published: June 2022

Abstract: The development of fine arts in early childhood is a stimulus to develop children's creativity. However, the development of art for the children of group B in TK Dharma Wanita Persatuan 1 Senggreng has not been seen optimally. The child looks doubtful, insecure, and often imitates. Through jumputan batik activities, it aims to increase children's confidence, curiosity, freedom to be creative and free to express their creative ideas. In this study using classroom action research, this research uses 4 stages, namely, planning, implementation, observation and reflection stages. This research was conducted in 2 cycles. This data collection technique uses observation, interview, and documentation techniques. The result of pre-action class success percentage is 41.1 percent. The results showed that in the first cycle the percentage of class success through jumputan batik activities was 61.75 percent with the category less achieved. Meanwhile, in the second cycle, the percentage of class success was 82.3 persen with many categories being achieved. From the results of the research, the jumputan batik activity can improve the fine arts skills of group B children in TK Dharma Wanita Persatuan 1 Senggreng.
Keywords: ; fine arts; early childhood
Abstrak
Perkembangan seni rupa pada anak usia dini merupakan suatu rangsangan yang dilakukan untuk mengembangkan kreativitas anak. Namun, pada perkembangan seni rupa anak kelompok B di TK Dharma Wanita Persatuan 1 Senggreng belum terlihat optimal. Anak terlihat ragu, tidak percaya diri, dan sering meniru. Melalui kegiatan membatik jumputan bertujuan meningkatkan kepercayaan diri anak, rasa ingin tahu, bebas berkreasi serta bebas menuangkan ide-ide kreatifnya. Pada penelitian ini menggunakan penelitian tindakan kelas, penelitian ini menggunakan 4 tahapan yaitu, tahap perencanaan, pelaksanaan, observasi dan refleksi. Penelitian ini dilakukan 2 siklus. Teknik pengumpulan data ini menggunakan teknik observasi, wawancara, dan dokumentasi. Hasil pratindakan persentase keberhasilan kelas sebesar 41,1 persen. Hasil penelitian menunjukkan bahwa pada siklus I presentase keberhasilan kelas melalui kegiatan membatik jumputan diperoleh sebesar 61,75 persen dengan kategori kurang tercapai. Sedangkan, pada siklus II di peroleh presentase keberhasilan kelas sebesar 82,3 persen dengan kategori banyak yang tercapai. Dari hasil penelitian maka kegiatan membatik jumputan dapat meningkatkan kemampuan seni rupa anak kelompok B di TK Dharma Wanita Persatuan 1 Senggreng.
A cross-sectional population-based study looked at the prevalence of neck discomfort in people with metabolic syndrome
Authors: Aloria Jitendra , Nayak Priyanka , Gahnolia Vijendra 
Published: June 2022

Metabolic syndrome (MetS) is becoming more prevalent. Obesity has been linked to neck pain, but the prevalence of neck discomfort in MetS patients has not been explored. The goal of this study was to look at the link between MetS and neck discomfort.A total of 1,000 middle-aged Indian individuals were included in the study. A total of 450 men and 550 women took part in the competition. Males and females were both 47 years old on average. Clinical and biochemical tests were performed. A standard questionnaire was completed by the participants. The 12-item General Health Questionnaire was used to measure psychological discomfort (GHQ-12). Neck discomfort was described as neck pain that was experienced on a daily basis. The National Cholesterol Education Program (NCEP) criteria were used to define MetS. A bootstrap-type t-test or the Chi-Square test were used to make statistical comparisons between the groups. Generalized linear models using age, smoking, alcohol consumption, exercise, and GHQ-12 score as factors were used to construct risk ratios for neck discomfort.MetS was found in 455 men and 550 women in the study. Neck discomfort was linked to BMI and waist circumference in males but not in females. Antihypertensive medicine was used more frequently by neck pain patients than by non-neck pain patients. There were no significant changes in smoking, physical activity, blood pressure, lipids, glucose, or CRP levels. Neck pain was reported by 8.7% (95 percent CI, 4.8 percent to 13%) of male patients without MetS and 17%.
Subtrochanteric locking screw–The key to success in intertrochanteric fractures
Authors: Kumar S Krishna , Sharan Sastha K , Suthagar T S Prabin 
Published: June 2022

The introduction of proximal femoral nail improved the results in unstable intertrochanteric fractures. Several factors determine the outcome of intramedullary nail including working length of the nail. Addition of subtrochanteric locking screw to a reconstruction nail will reduce the working length providing biomechanical advantage.177 adult patients treated with reconstruction nail with a subtrochanteric locking screw for intertrochanteric fracture of the femur in our institution from January 2011 to December 2020 were prospectively analyzed. Final outcome is assessed by radiological union after a followup period of minimum 6 months postoperatively. 3 patients had varus malreduction, 4 patients had screw backout and one patient had screw migration. We didn’t encounter any wound complications in our study. Complication rates were much lesser when compared with studies done on standard proximal femoral nail.Reconstruction nail with a subtrochanteric locking screw reduces the working length of the nail and improves the outcome in intertrochanteric fractures.