bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Analysis of Oral Nutrition Support Needs in Chinese Postoperative Gastric Cancer Patients: Based on Information From Internet
Authors: Tian Qiuju , Qin Liyuan , Zhu Weiyi , Wu Beiwen 
Published: February 2022

Abstract
Purpose: The study aimed to explore oral nutrition support needs in Chinese gastric cancer patients after gastrectomy by analyzing patients question on the internet.Methods: We searched Baidu website for diet question relating to stomach cancer undergoing gastrectomy. Content analysis was used to analyze the data material, Natural language processing & information retrieval sharing platform was used to analyze the sentiment tendency and sentiment attributes of all questions.Results: A total of 1420 diet-related questions were posed during the time before discharge and after gastrectomy several years. About 83.87% of all questions were about what and how to eat after gastric cancer. The results of emotional orientation of oral nutrition problems in patients after gastrectomy was generally positive (positive vs negative score: 1758 VS –1531), but the emotional orientation of diet and symptom problems was generally negative (positive vs negative score: 256.5 VS –410). The oral nutritional requirement of gastric cancer patient included oral nutrition-related solutions provided by professional staff, dietary and prognosis information, food metabolism information, dietary information, oral nutritional supplements information, symptom support, nutrition monitor, psychological support, and exercise information. Conclusions: The dietary problems of patients with gastric cancer after surgery mainly involve how to eat, the causes of diet-related symptoms and treatment methods. Patients and their caregivers need professional person to support their nutrition need, and the nutrition need include dietary and prognosis information, food metabolism information, dietary information, oral nutritional supplements information, symptom support, nutrition monitor, psychological support, and exercise information. The study clarified the specific needs of oral nutrition for patients after gastric cancer surgery, laying a foundation for the formulation of intervention programs.
Biogenic surfactant mediated facile synthesis of visible light sensitized Zn/Mg co-doped TiO2 Nanomaterials– A Green approach: Evaluation of photocatalytic activity by degradation of Amido Black 10B
Authors: Tirukkovalluri Siva Rao , Jaishree Genji , Divya Gorli , Chippada M.L.V. Prasanna , Raju Imandi Manga 
Published: February 2022

Abstract
Visible light driven Zn and Mg co-doped TiO2 nanomaterials were synthesized by varying dopant concentrations in presence of biogenic surfactant Sapindus emerginatus biogenic extract via Solgel method and has been successfully applicated to the degradation of Amido Black 10B, an exemplary anionic textile azo dye pollutant. In this study, explored the potent capping properties of biogenic extract surfactant by encapsulating the Zn/Mg co-doped TiO2. In a view to assess the physical and optical properties of as synthesized catalyst, various advanced instrumental techniques were adopted. The Transmission Electron Microscopy and Scanning Electron Microscopy analysis shows the formation of small particle size (6.92 nm) and rough surface respectively pertaining to ZMT4S2. The substitutional doping of Zn and Mg into TiO2 framework by substituting Ti4+ ion and the encapsulation of surfactant around catalyst was confirmed by Fourier Transform-Infrared Spectroscopy (FTIR) spectral studies. The surface area of the ZMT4S2 was found to be high (195.20 m2 g−1) as compared with undoped TiO2 (32.50 m2 g−1) and ZMT4 (7.02 m2 g−1). The red shift in the absorbance was observed for all the catalysts analyzed using UV-DRS making them active in visible region with maximum shift corresponds to a band energy difference of 2.1 eV for ZMT4S2. The sensitivity of the catalyst towards visible light was confirmed by its band gap energy measurement using UV-vis DRS. The anatase phase of all the catalysts were confirmed using Powder X-ray diffraction. The composition and wt% of dopants revealed the EDX spectra agrees well with the calculated value. The slightly shifted frequency bands (FTIR) further confirmed the doping of Zn and Mg. The characterization analysis reports further accounts for the effective degradation of AB10B dye (99%) taking place within 20 min of irradiation time at optimized reaction parameters such as best dopant concentration ZMT4, catalyst dosage (100 mgL−1), dye concentration (10 mgL−1) and solution pH 3.
Impact of hydrogeological assumptions and their variation on the calculated surface uplift above flooded coal mines
Authors: Vervoort Andre 
Published: February 2022

Abstract
Upward surface movement or uplift has been extensively observed above abandoned deep coal mines. Detailed analysis of measurements indicated that the process of uplift is a complex phenomenon. The observed uplift is linked to the flooding of the underground infrastructure and rock mass. The distribution of water pressure at the end of the mining phase and their increase during the flooding is an important aspect in all estimations. Various assumptions of this distribution at the start of the flooding phase are studied, i.e., from a zero-water pressure to a linear decrease between top and bottom longwall panel. There are also various scenarios possible of how the water pressures change as a function of time, i.e., from filling an open reservoir from bottom to top, to a systematic change in the linear downward trend. The original assumed scenario, i.e., a linear trend, remains the most likely option. It provides the best fit between the estimated uplift values and the large amount of remote sensing measurements, along north-south transects in the Belgian Campine coal basin. However, further improvements and analyses certainly are still needed.
Incidence of preterm births admissions in Uganda, 2015-2019
Authors: Morukileng Job , Mugwanya Wilberforce , Mutumba Robert , Katusiime Maureen , Byaruhanga Aggrey , Gonahasa Doreen N. , Amodan Bob Omoda , Kabwama Steven , Kadobera Daniel , Bulage Lilian , Ario Alex Riolexus 
Published: February 2022

Abstract
Background: Complications of preterm births are the largest cause of neonatal deaths and the second leading cause of deaths among children <5 years globally. The preterm birth rate in Uganda is estimated at 6.6%. Reduction of this rate is needed to achieve the United Nations Sustainable Development Goal to end all preventable deaths among newborns and children aged <5 years by 2030. We describe the trends and distribution of preterm births admissions in Uganda during 2015-2019 for advocacy, planning, and targeted interventions.Methods: We used national preterm birth admissions data from 2015-2019 abstracted from the District Health Information System 2 (DHIS2) to calculate national, regional and district annual incidence of preterm births admissions. DHIS2 defines preterm birth as birth occurring <37 weeks of gestation. We used preterm birth admissions as numerator and the total livebirths (LB) as the denominator. We used line graphs to demonstrate the trend of annual incidence for the national and regional levels and choropleth maps to show district level distribution. Significance of the trend of annual incidence was tested using modified Poisson regression with unbiased sandwich standard errors, considering calendar year as independent and preterm births admissions as dependent variableResults: The national annual incidence of preterm birth admissions/1,000 LB has significantly increased from 3 in 2015 to 14 in 2019 (Incidence Risk Ratio (IRR)=1.3, p=0.003). The annual incidence of preterm birth admissions/1,000 LB increased significantly in three regions of Uganda during 2015 -2019 (Central Region from 3 to 21, IRR=1.5, p<0.0001; Western Region from 4 to 15 IRR=1.2, p=0.039; Northern Region from 3 to 10, IRR=1.2, p=0.008; Eastern Region from 2 to 8, IRR=1.3, p=0.086). The Choropleth map showed minimal clustering of high incidence of preterm birth admissions at district level.Conclusion: Incidence of preterm birth admissions increased nationally and regionally in Uganda from 2015-2019. There is need to plan for and prepare health facilities to manage preterm labor and preterm babies, as well as identifying reasons for the increase. Equipping health facilities and training health workers to manage preterm labor and babies should be prioritized.
Multi-Task Learning to Leverage Partially Annotated Data for PPI Interface Prediction
Authors: Capel Henriette , Feenstra K. Anton , Abeln Sanne 
Published: February 2022

Abstract
Protein protein interactions (PPI) are crucial for protein functioning, nevertheless predicting residues in PPI interfaces from the protein sequence remains a challenging problem. In addition, structure-based functional annotations, such as the PPI interface annotations, are scarce: only for about one-third of all protein structures residue-based PPI interface annotations are available. If we want to use a deep learning strategy, we have to overcome the problem of limited data availability. Here we use a multi-task learning strategy that can handle missing data. We start with the multi-task model architecture, and adapted it to carefully handle missing data in the cost function. As related learning tasks we include prediction of secondary structure, solvent accessibility and buried residue. Our results show that the multi-task learning strategy significantly outperforms single task approaches. Moreover, only the multi-task strategy is able to effectively learn over a dataset extended with structural feature data, without additional PPI annotations. The multi-task setup becomes even more important, if the fraction of PPI annotations becomes very small: the multi-task learner trained on only one-eighth of the PPI annotations -- with data extension -- reaches the same performances as the single-task learner on all PPI annotations. Thus, we show that the multi-task learning strategy can be beneficial for a small training dataset where the protein's functional properties of interest are only partially annotated.
The Timing, Duration And Magnitude of The 8.2 Ka Event In Global Speleothem Records
Authors: Parker Sarah E. , Harrison Sandy P. 
Published: February 2022

Abstract
Abrupt events are a feature of many palaeoclimate records during the Holocene. The best example is the 8.2 ka event, which was triggered by a release of meltwater into the Labrador Sea and resulted in a weakening of poleward heat transport in the North Atlantic. We use an objective method to identify rapid climate events in globally distributed speleothem oxygen isotope records during the Holocene. We show that the 8.2 ka event can be identified in >70% of the speleothem records and is the most coherent signal of abrupt climate change during the last 12,000 years. The isotopic changes during the event are regionally homogenous: positive oxygen isotope anomalies are observed across Asia and negative anomalies are seen across Europe, the Mediterranean, south America and southern Africa. The magnitude of the isotopic excursions in regions close to and far from the North Atlantic are statistically indistinguishable. There is no significant difference in the duration and timing of the 8.2 ka event between regions, or between the speleothem records and Greenland ice core records. Our study supports a rapid and global climate response to the 8.2 ka freshwater pulse into the North Atlantic, likely transmitted globally via atmospheric teleconnections.
H∞ Model Based Control via Mixed Sensitivity for 2DOF Control of Twin Rotor MIMO System With Experimental Validation
Authors: Abbas Nadir , Zar Ali , Raheem Abdur , Shakoor Rabia , Arfeen Zeeshan Ahmad , Rashid Muhammad , Umer Farhana , Safdar Nouman , Liu Xiaodong 
Published: February 2022

Abstract
This article provides a comprehensive study about optimization and real-time implementation of H∞ model-based controller for uncertain systems (having external perturbations) using robust control methods. The complicated air vehicle modeling is quite difficult because of highly nonlinear behavior, un-modeled states, and cross-coupling effect. The helicopter flight control also depends on two rotors generating continuous thrust simultaneously in two different directions. Simple linear feedback controllers cannot ensure the stability of highly nonlinear systems like a helicopter. The controllability and observability full rank matrix output ensure the credibility of the system before a controller design. The design of a robust controller for the desired flight control, demands the availability of all its states and varying parameters for real-time robust feedback control. However, its prototype, Twin-rotor MIMO System (TRMS) facilitates the researchers and control engineers in terms of the real-time environment of a helicopter flight control. Various control strategies are presented to elaborate the behavior of the MIMO system and the limitations of robust control methods. Each control strategy has been comprehensively discussed with the stability analysis and the design requirements. The considered control techniques, such as the loop-shaping control and H∞ model-based control augmented with mixed sensitivity control function, make use of control in such a way that robust stability and robust performance are ensured for highly nonlinear systems. Model-based H∞ optimization technique elaborates the robustness and stability of the system by reducing tracking error of all its states towards origin and thereafter system becomes stable for an infinite period. The loop-shaping control performance as compared to H∞ model-based control has some limitations to ensure closed-loop robustness and real-time implementation under perturbations. The performance evaluation is done at the end which shows that the H∞ model-based control gives optimal robust performance including perturbations and coupling effect. The real-time implementation on MATLAB/Simulation via personal computer validates the worth of the optimization method in the presence of uncertainties (matched, unmatched, coupling effect) of a linearized state-space model of the TRMS system.
Brief Report: Ionising Radiation Induces Autophagy in the Adult Drosophila Brain and Intestine
Authors: Trinca Terrence M , Malik Bilal R 
Published: February 2022

Abstract
Exposure to various genotoxic and oxidative stresses can induce changes in the internal state of a cell leading to cell death. Ionizing radiation is routinely used in clinics to treat various types of cancers, with secondary effects sometimes damaging internal organs particularly the gut. Drosophila melanogaster has become one of the most trusted model organisms to study human disease and various biological pathways. Here we have used gamma radiation to determine for the first time whether they have an effect on autophagy in two different tissues in Drosophila; the gut and the brain. We find that in both tissues exposure to radiation leads to an increase in autophagy.
Metal-to-metal charge transfer driven by electropositive species for stable anionic redox
Authors: Kim Min-Ho , Jang Haeseong , Lee Eun Ryeol , Park Jaehyun , Kim Taewon , Seo Jeongwoo , Jung Young Hwa , Kang Seok Ju , Cho Jaephil , Kim Min , Seo Dong-Hwa , Lee Hyun-Wook 
Published: February 2022

Abstract
Apart from conventional redox chemistries, exploring high-voltage redox processes, such as high-valent redox of a transition metal (TM) or novel anionic redox, is challenging due to unstable energy states correlated with destructive structural disorder in intercalation-type cathode materials. Here, we show a new strategy to design high-energy-density 4d-based Li-excess oxides with strong structural reversibility by substituting electropositive species. It is known that TMs in 4d-based Li-excess oxides, in contrast to 3d-based oxides, actively interact with neighboring oxygen ligands, inducing b1/b1* energy levels. Metal-to-metal charge transfer, driven by covalency competition within the asymmetric TM3d-O-TM4d backbone, induces a larger overlap between electronegative species and oxygen ligands, leading to stable high-voltage redox. Furthermore, we reveal that redox-inactive dopants control the reversibility of cation migration, thereby extending the battery lifetime. These insights open new perspectives for the control of intrinsic redox chemistry and enable rational designs for high-energy-density Li-excess cathodes.
Protective Effect of Resveratrol Against Cadmium-Induced Toxicity On Ovine Oocyte In Vitro Maturation And Fertilization
Authors: Piras Anna Rita , Ariu Federica , Maltana Alessio , Leoni Giovanni Giuseppe , Martino Nicola Antonio , Mastrorocco Antonella , Dell’Aquila Maria Elena , Bogliolo Luisa 
Published: February 2022

Abstract
Background: Heavy metal cadmium (Cd) is a widespread environmental contaminant with a potential toxicity that might negatively affect female reproduction and fertility. It has been reported that Cd exposure impaired the quality of oocytes and led to a defective maturation and fertilization, through oxidative stress induction. Resveratrol (Res) is a natural polyphenol with strong antioxidant properties that exhibited protective role in preventing oocyte redox homeostasis disruption and quality decline. Here, we explored whether the addition of Res to in vitro maturation (IVM) medium might act as a protection against Cd-induced toxicity on ovine oocyte maturation and fertilization. Firstly, we evaluated the effect of supplementing IVM medium with two different Res concentrations (1 and 2 μmol/L) on nuclear maturation and fertilization of oocytes matured under CdCl2 (2 μmol/L) exposure. Therefore, the concentration of 1 μmol/L Res was selected to analyse intracellular ROS levels, mitochondrial (mt) distribution and activity, chromatin configuration, cytoskeleton morphology, cortical granules (CGs) distribution and mRNA expression of genes associated with cellular response to oxidative stress (i.e. SIRT1, SOD 1, GPX1, GSR, CAT ) in Cd-exposed in vitro matured oocytes. Results: We found that 1μmol/L Res was effective to recover the reduced oocyte meiotic competence induced by Cd exposure, while treatment with Res, at both tested concentrations, sustained oocyte ability to be normally fertilized and decreased polyspermic fertilization. Moreover, we demonstrated that 1 μmol/L Res mitigated Cd-induced alterations of oocyte cytoplasmic maturation by reducing reactive oxygen species (ROS) accumulation, preventing mt dysfunction, maintaining the correct meiotic spindle and cortical F-actin assembly and the normal cortical granule distribution as well as up-regulating SIRT1 , SOD1 and GPX1 genes. Conclusions: Taken together, our findings highlighted the beneficial influence exerted by Res in preventing Cd-induced disturbance of nuclear and cytoplasmic maturation and subsequent fertilization in ovine oocytes. Res treatment may help to establish defence strategies counteracting Cd-induced toxicity on the female gamete.
A Novel 7 RNA-Based Signature for Prediction of Prognosis and Therapeutic Responses of Wild-Type BRAF Cutaneous Melanoma
Authors: Sun Ruizheng , Liu Yaozhong , Lei Cheng , Tang Zhenwei , Lu Lulixia 
Published: February 2022

Abstract
Background: The prognosis of wild-type BRAF cutaneous melanoma (WT Bf-CM) patients remains poor due to the lack of therapeutic options. However, few studies have investigated the factors contributing to the prognosis of WT Bf-CM patients.Methods: In this paper, we proposed and validated a novel 7-RNA based signature to predict the prognosis of WT Bf-CM by analyzing the information from TCGA database.Results: Dependence of this signature to other clinical factors were verified and a nomogram was also drawn to promote its application in clinical practice. Functional analysis suggested that the predictive function of this signature might attribute to the prediction of the up-regulation of RNA splicing, transcription, and cellular proliferation in the high-risk group, which have been demonstrated to be linked to malignancy of cancer. Moreover, therapy response analysis supported that this signature could predict the responses of PI3K/Akt/mTOR pathway based drugs in WT Bf-CM patients. Conclusion: Collectively, this study will provide a preliminary bioinformatics evidence for the molecular mechanism and potential drug targets that could improving WT Bf-CM prognosis.
Research on the Application of Surface Wave Method for the Precise Detection of Shallow Coal Seam Mined-Out Area and Overburden
Authors: Li Yu , Yang Zhi , Zou Guangui , Zhao Fei , Liu Yan 
Published: February 2022

Abstract
To finely detect the boundary of a shallow coal mined-out area, as well as the extent of the overburden affected by the mined-out area, and to analyze the factors and interrelationships between the detection depth and lateral resolution of the multichannel analysis of surface waves (MASW) method, a low-frequency focusing factor is introduced into the phase-shift method, and a low-frequency focusing phase-shift method is proposed to improve the detection depth and lateral resolution of the MASW method. The method is applied to the processing and analysis of measured active-source surface waves. The results show that the low-frequency focused phase-shift method has the significant advantage of extracting the dispersion energy at low-frequency side from the short receiver spread. The receiver-spread length of the measured data used to calculate the dispersion energy is 35 m, which meets the 70 m detection depth of the target coal mined-out area. The measured data were processed to obtain high-precision horizontal slices of the shear wave velocity along the coal seam and in the overburden at different depths. The former clearly identify the boundaries of the coal mined-out areas and the locations and geometries of the security coal pillars and estimate the main coal mining direction to be approximately 23° NW, which is in general agreement with the actual direction of 21° NW of the back workings in the mining area of the study site. One mined-out area of approximately 30 m in width, one mined-out area greater than 50 m in width, and one roadway of approximately 10 m in width are inferred. The latter directly shows the extent of the overburden affected by the coal mined-out area gradually decreasing as the depth becomes shallower. The severe influence extent on the surface is delineated and mutually supported by the surface cracks in the village east of the research site. The effectiveness of the low-frequency focused phase-shift method in improving the depth and lateral resolution of the MASW method and the feasibility of the MASW method in precise detection of shallow coal mined-out area and overburden are confirmed.