bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum high-sensitive C-reactive protein is a simple indicator for all-cause among individuals with MAFLD
Authors: Huang Jiaofeng , Wang Mingfang , Wu Yinlian , Kumar Rahul , Lin Su 
Published: October 2022

High-sensitive C-reactive protein (hs-CRP) is one of the diagnostic components for metabolic (-dysfunction) associated fatty liver disease (MAFLD). This study aimed to explore the relationship between hs-CRP level and 25-year mortality in patients with MAFLD. The study data were from the Third National Health and Nutrition Examination Survey 1988–1994. All participants were followed up until December 2015 and the outcome of each participant was ascertained from National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence interval (CI) of all-cause mortality, cardiovascular-related mortality, and malignancy-related mortality. A total of 4,145 participants with MAFLD were included in final analysis. The median follow-up period was 22.3 years (interquartile range 16.9–24.2). There were 1,610 (38.8%) all-cause deaths. The leading cause of death was malignant neoplasms (365/1,610, 22.7%), followed by cardiovascular diseases (342/1,610, 21.2%). Of the 4,145 patients with MAFLD, 1,293 (31.2%) had an hs-CRP level greater than 0.5 mg/dl. Those with hs-CRP &gt; 0.5 mg/dl were older, more likely to be female and had greater derangements of metabolic profiles than those with lower hs-CRP. The results of Cox regression analysis showed that hs-CRP ≥ 0.5 mg/dl was an independent risk factor for all-cause mortality (HR = 1.394, 95% CI 1.253–1.551), cardiovascular mortality (HR = 1.497, 95% CI 1.190–1.885) and malignant neoplasms related mortality (HR = 1.290, 95% CI 1.030–1.615) after adjusting for risk factors. This study confirms that hs-CRP is an independent predictive factor of poor prognosis in patients with MAFLD.
Soybean resilience to drought is supported by partial recovery of photosynthetic traits
Authors: Elsalahy Heba H. , Reckling Moritz 
Published: October 2022

Climate change affects precipitation dynamics and the variability of drought frequency, intensity, timing, and duration. This represents a high risk in spring-sown grain legumes such as soybean. Yet, under European conditions, no evidence supports the potential recovery and resilience of drought-tolerant soybean cultivars after episodic drought, at different growth stages. A field experiment was conducted using a representative drought-tolerant cultivar of soybean (cv. Acardia), in 2020 and 2021, on sandy soils in Germany, applying four water regimes (irrigated, rainfed, early-drought, and late-drought stress). Drought stress was simulated by covering the plots during the event of rain with 6 × 6 m rainout shelters, at the vegetative (V-stage) and flowering (Fl-stage) stages. Drought response was quantified on plant height, chlorophyll fluorescence ratio (ChlF ratio), chlorophyll content (Chlc), and leaf surface temperature (LST), at different intervals after simulating drought until pod filling. Grain yield and yield components were quantified at the end of the growing season. Compared to rainfed conditions, a drought at V-stage and Fl-stage reduced significantly plant height, ChlF ratio, and Chlc by 20%, 11%, and 7%, respectively, but increased LST by 21% during the recovery phase. There was no recovery from drought except for Chlc after V-stage in 2021, that significantly recovered by 40% at the end of the growing season, signifying a partial recovery of the photochemical apparatus. Especially, there was no recovery observed in LST, implying the inability of soybean to restore LST within the physiological functional range (Graphical abstract). Under rainfed conditions, the grain yield reached 2.9 t ha-1 in 2020 and 5.2 t ha-1 in 2021. However, the episodic drought reduced the yield at V-stage and Fl-stage, by 63% and 25% in 2020, and 21% and 36% in 2021, respectively. To conclude, the timing of drought was less relevant for soybean resilience; however, pre- and post-drought soil moisture, drought intensity, and drought duration were likely more important. A drought-tolerant soybean cultivar may partially be drought-resilient due to the recovery of photosynthetic traits, but not the leaf thermal traits. Overall, these findings will accelerate future efforts by plant breeders, aimed at improving soybean drought resilience.
The psychological impact of esophageal cancer screening on anxiety and depression in China
Authors: Zhu Juan , Ma Shanrui , Chen Ru , Liu Zhaorui , Liu Zhengkui , Wei Wenqiang 
Published: October 2022

ObjectiveThe psychological impact of screening is unclear and has been ignored. This study aimed to evaluate the psychological impact of esophageal cancer (EC) screening on anxiety and depression in China.Materials and methodsA multicenter, population-based study in five high-risk regions of EC was conducted from 2019 to 2020. Residents were recruited and underwent endoscopic screening and then were diagnosed with normal, esophagitis, low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia (HGIN) and EC. Subjects who did not participate in the screening were referred to as the control group. We surveyed their anxiety and depression levels at baseline and after endoscopy and informed them of different pathological results to evaluate the psychological impact of the screening process.ResultsA total of 2,337 subjects completed all surveys in the screening process (normal: 355, esophagitis: 1,713, LGIN: 213, HGIN: 43 and EC: 13), with 63 controls. The levels of anxiety and depression of screeners were significantly higher than those of controls (P &lt; 0.001). The fluctuation of anxiety and depression showed a “V” pattern in the screening process. The prevalence of anxiety symptoms at baseline, after endoscopy and after knowing the pathological results was 5.6, 0.3, and 3.2%, respectively (P &lt; 0.001), and the corresponding prevalence of depression was 3.6, 0.2, and 2.1%, respectively (P &lt; 0.001). With the aggravation of pathological results, the levels of anxiety and depression increased significantly (P &lt; 0.001), especially in patients informed of HGIN (16.3 and 9.3%) and EC (23.1 and 30.8%).ConclusionParticipation in endoscopic screening may bring short-term adverse psychological effects, especially at baseline and knowing the pathological results. More attention should be given to participants waiting for endoscopic screening. The method of informing the screening results of HGIN and EC should be improved. Further precise screening is needed to concentrate on high-risk groups to reduce the psychological impact of screening.
The application of metagenomic next-generation sequencing for Angiostrongylus eosinophilic meningitis in a pediatric patient: A case report
Authors: Liu Jing , Tao Jinhao , Chen Weiming , Wang Tingting , Chen Xin , Shen Meili , Ou Qiuxiang , Zhang Yunjian , Ding Yifeng , Wu Jufang , Cheng Xunjia , Lu Guoping , Yan Gangfeng 
Published: October 2022

BackgroundAngiostrongyluseosinophilic meningitis (AEM) is a rare yet emerging disease caused byAngiostrongylus cantonensisinfection. Its atypical symptoms may delay the diagnosis and cause fatal outcomes, especially in the early stages of infection and among children.Case presentationHere we reported the use of metagenomic next-generation sequencing (mNGS) to facilitate the diagnosis and treatment of an 8-year-old boy with severeA. cantonensisinfection. The mNGS tests consistently identified the infection ofA. cantonensisprior to the detection by the immunologic method and confirmed it as AEM. Owing to the multidisciplinary team (MDT)-administrated treatments and close disease monitoring based on regular clinical tests and sequential mNGS tests, the patients eventually fully recovered from severe infectious conditions.ConclusionThis case demonstrated the advantages of mNGS for early diagnosis of AEM in pediatric patients, highlighting its application for pan-pathogen detection, as well as disease monitoring for severeA. cantonensisinfection.
Relative deprivation and depressive symptoms among Chinese migrant children: The impacts of self-esteem and belief in a just world
Authors: Xiong Meng , Hu Zhiqin 
Published: October 2022

BackgroundStudies have shown that relative deprivation is a risk factor for depressive symptoms, but the underlying mechanisms are not yet clarified. Thus, this study formulated a moderated mediation model to investigate the mediating role of self-esteem and the moderating role of belief in a just world between relative deprivation and depressive symptoms among rural-to-urban migrant children.MethodsA sample of 1,076 Chinese migrant children (Mage = 12.25 years, SD = 1.66) completed measurements of relative deprivation, self-esteem, belief in a just world, and depressive symptoms. Furthermore, the mediating mechanism and moderating effect of the study were explored with the SPSS PROCESS macro (Models 4 and 7).ResultsThe results showed a significant positive association between relative deprivation and depressive symptoms, with self-esteem partially mediating this association. Moreover, belief in a just world moderated the association between relative deprivation and self-esteem. Namely, the indirect effect of self-esteem was moderated by belief in a just world. Specifically, the mediating effect was stronger for migrant children with higher levels of belief in a just world.ConclusionThese findings broaden our knowledge of how and when relative deprivation influences depressive symptoms among migrant children. Therefore, appropriate measures should be taken to prevent and manage migrant children' depression and provide them with corresponding guidance. Some measures could be taken by schools and educators to help migrant children with high relative deprivation in improving their self-esteem and belief in a just world, such as self-reference tasks and psychological intervention programs.
Screen-based sedentary behaviors but not total sedentary time are associated with anxiety among college students
Authors: Huang Tao , Zheng Kefeng , Li Shiyuan , Yang Yanxiang , Kong Lingxuan , Zhao Ying 
Published: October 2022

ObjectiveThe purpose of the study was to investigate the associations of device-measured total sedentary time and screen-based sedentary time with anxiety in college students.MethodsThree hundred and twenty-one college students (mean age = 19.72 ± 1.18, 55.8% females) were recruited from Shanghai, China. Total sedentary time was objectively measured using accelerometry, while screen-based sedentary time was self-reported. Anxiety symptom was evaluated using the Self-Rating Anxiety Scale. Linear regression modeling was used to assess the associations of total sedentary time and screen-based sedentary time with anxiety symptom.ResultsAccelerometer-assessed total sedentary time was not associated with anxiety symptom. Prolonged sedentary time on TV and movie viewing (&gt;2 h on weekdays) and social media using (&gt;2 h on weekdays and weekend) were associated with a higher level of anxiety. However, time on video gaming and recreational reading was not associated with anxiety symptom.ConclusionThe findings indicated that screen-based sedentary behaviors but not total sedentary time were associated with anxiety symptom among college students. The associations of screen-based sedentary behaviors with anxiety symptom varied by the types of screen time.
Depth-resolved photochemical production of hydrogen peroxide in the global ocean using remotely sensed ocean color
Authors: Zhu Yuting , Powers Leanne C. , Kieber David J. , Miller William L. 
Published: October 2022

Hydrogen peroxide (H2O2) is an important reactive oxygen species (ROS) in natural waters, affecting water quality via participation in metal redox reactions and causing oxidative stress for marine ecosystems. While attempts have been made to better understand H2O2 dynamics in the global ocean, the relative importance of various H2O2 sources and losses remains uncertain. Our model improves previous estimates of photochemical H2O2 production rates by using remotely sensed ocean color to characterize the ultraviolet (UV) radiation field in surface water along with quantitative chemical data for the photochemical efficiency of H2O2 formation. Wavelength- and temperature-dependent efficiency (i.e., apparent quantum yield, AQY) spectra previously reported for a variety of seawater sources, including coastal and oligotrophic stations in Antarctica, the Pacific Ocean at Station ALOHA, the Gulf of Mexico, and several sites along the eastern coast of the United States were compiled to obtain a “marine-average” AQY spectrum. To evaluate our predictions of H2O2 photoproduction in surface waters using this single AQY spectrum, we compared modeled rates to new measured rates from Gulf Stream, coastal, and nearshore river-outflow stations in the South Atlantic Bight, GA, United States; obtaining comparative differences of 33% or less. In our global model, the “marine-average” AQY spectrum was used with modeled solar irradiance, together with satellite-derived surface seawater temperature and UV optical properties, including diffuse attenuation coefficients and dissolved organic matter absorption coefficients estimated with remote sensing-based algorithms. The final product of the model, a monthly climatology of depth-resolved H2O2 photoproduction rates in the surface mixed layer, is reported for the first time and provides an integrated global estimate of ∼21.1 Tmol yr−1 for photochemical H2O2 production. This work has important implications for photo-redox reactions in seawater and improves our understanding of the role of solar irradiation on ROS cycling and the overall oxidation state in the oceans.
A novel approach for portal system reconstruction in liver transplant patients with grade IV portal vein thrombosis: Case study and literature review
Authors: Qu Wei , Zhu Zhi-Jun , Wei Lin 
Published: October 2022

BackgroundPortal vein thrombosis is a common problem of end-stage liver disease in patients with portal hypertension and Yerdel grade IV thrombosis may be a contraindication for liver transplantation. Advances in surgical technique have indicated the feasibility of liver transplantation with PVT such as Reno-portal anastomosis, cavo-portal hemitransposition, but low graft portal blood perfusion and regional portal hypertension were the limitations.MethodsWe introduce a new approach for portal system reconstruction in a patient underwent liver transplantation: A 28-year-old male was diagnosed with Budd-Chari syndrome and portal hypertension with grade IV portal vein thrombosis.ResultsThe “Pull-out” technique was applicated for thrombectomy, which can aid in exposing the superior mesenteric vein and portal vein branches and reducing technical difficulties associated with the identification and dissociation of surrounding anatomical structures. To collect sufficient portal vein blood perfusion and avoid regional portal hypertension, the portal vein system was reconstructed through double-approach procedure: reno-portal anastomosis combined with portal-portal anastomosis.ConclusionBased on a precision preoperative evaluation, application of the Pull-out technique and double-approach procedure may be an effective method of thrombectomy especially in cases of grade IV portal vein thrombosis.
Gastric transcatheter chemoembolization can resolve advanced gastric cancer presenting with obstruction
Authors: Peng Dong , Zhang Bin , Yuan Chao , Tong Yue , Zhang Wei 
Published: October 2022

BackgroundGastric transcatheter chemoembolization (GTC) is an interventional minimal invasive method, which has never been mentioned in the previous literature for advanced gastric cancer with obstruction. The purpose of this study was to evaluate its safety and efficacy in treating advanced gastric cancer with obstruction.MethodsAdvanced gastric cancer patients with obstruction who underwent GTC were retrospectively analysed from June 2017 to January 2020. Baseline information, peri-intervention data, and post-intervention follow-up information were collected. Clinical data obtained before and after the GTC were compared, and the survival of all patients was analysed.ResultForty-Two patients were included in this study. 42 (100%) patients achieved technical success, and 22 (52.4%) achieved clinical success. The median time of the GTC was 83 (30.0–180.0) minutes, and the median time of hospitalization after GTC was 3 (1–6) days. One patient experienced abdominal pain during and after GTC. Twenty (47.6%) of the 42 patients underwent gastrectomy after intervention. The pre-intervention gastric outlet obstruction scoring system (GOOSS) was 1 (0–1) and the post-intervention GOOSS was 2 (0–3) (p = 0.000 &lt; 0.05). The median follow-up time was 9.5 (3–35) months, and the overall survival time was 14 months. In the univariate survival analysis, a significant difference was observed between patients who did or did not undergo radical gastrectomy after GTC (p = 0.014 &lt; 0.05).ConclusionsGTC is a safe and effective treatment, and furthermore, it could be an alternative method in treating advanced gastric cancer with obstruction.
Operability of atrial septal defect with borderline pulmonary vascular resistance index: A study in developing country
Authors: Lilyasari Oktavia , Istisakinah Rini , Ariani Rina , Rahmat Budi , Liastuti Lies Dina , Kurniawati Yovi , Muliawan Hary Sakti , Sukmawan Renan 
Published: October 2022

BackgroundPulmonary arterial hypertension secondary to atrial septal defect (ASD) is an important determinant of morbidity and mortality in defect closure. We aimed to compare perioperative outcome between preoperative borderline and low pulmonary vascular resistance index (≥4 WU.m2 and &lt;4 WU.m2, respectively) in surgical closure of secundum atrial septal defect with concomitant pulmonary arterial hypertension.Methods and resultsThis was a single-center retrospective cohort study between January 2015 and January 2020. We classified patients with low and borderline PVRI who underwent ASD closure and recorded the perioperative outcomes.ResultsWe analyzed a total of 183 patients with atrial septal defect and pulmonary arterial hypertension; 92 patients with borderline PVRI and 91 patients with low PVRI. Borderline pulmonary vascular resistance index was not associated with increased risk of postoperative mortality (p = 0.621; OR0.48, 95% CI 0.04–5.48), but associated with higher risk of overall morbidity in bivariate analysis (p = 0.002; OR3.28, 95% CI 1.5–6.72). Multivariate analysis showed positive association of borderline pulmonary vascular resistance index (p = 0.045; OR2.63, 95% CI 1.02–6.77) and preoperative tricuspid valve gradient ≥64 mmHg (p = 0.034; OR2.77, 95% CI 1.08–7.13) with overall morbidity.ConclusionThere is no difference in incidence of in-hospital mortality between preoperative borderline and low pulmonary vascular resistance index patients. However, preoperative borderline pulmonary vascular resistance index and tricuspid valve gradient ≥64 mmHg are associated with increased overall morbidity after surgical closure in secundum atrial septal defect patients with pulmonary arterial hypertension.
Analysis of the implementation of dental disease prevention programs in the pediatric dental service in several constituent entities of the Russian Federation
Authors: Yanushevich O. O. , Krikheli N. I. , Kiselnikova L. P. , Zueva T. E. 
Published: October 2022

Relevance. High dental disease incidence in children is still a relevant problem of public health care in Russia. Regional or national oral disease incidence rates may decrease via the introduction of state or Regional prevention programs. School dentistry is crucial in the pediatric dental care system. Different socio-economic, climatic and geographical conditions of various Regions of the Russian Federation affect the possibilities of preventive program implementation in the child population. Purpose – to evaluate the implementation of dental disease prevention programs in pediatric dental services in several constituent entities of the Russian Federation.Materials and methods. In 2020, employees of Moscow State University of Medicine and Dentistry visited the Regions of the Russian Federation 39 times within the implementation of the national project "Healthcare" and national medical centre activities. In these Regions, the study examined the following parameters: availability of a Regional dental disease prevention program, the functioning of dental offices in educational institutions, dental checkup coverage rate in children.Results. The study revealed that most Regions have school-based dental offices in the pediatric dental service. School-based dental offices provide treatment and prevention procedures. The analysis showed that all studied constituent entities carry out dental checkups. However, the dental checkup coverage rate in children varies greatly.Conclusions. A small number of Regions (23.07%) have approved and are implementing a Regional prevention program, several entities (20.51%) are validating similar programs. And the majority of the studied constituent entities (56.41%) don’t have Regional prevention programs.
Analisis Beban Kerja Operator pada Stasiun Boiler Menggunakan Cardiovascular Load (CVL) (Studi Kasus: PT. Socfindo Indonesia Perkebunan Seunagan)
Authors: Samosir Josua , Sofiyanurriyanti Sofiyanurriyanti 
Published: October 2022

PT. Socfindo Indonesia Perkebunan Seunagan merupakan perusahaan yang bergerak dibidang produksi Crude Palm Oil (CPO) dan Inti sawit (biji kernel). Di perusahaan sering terjadi nya stem naik turun saat produksi dimulai yang dimana bahan bakar boiler harus diisi setiap 5 menit sekali. Penelitian ini dilakukan di stasiun boiler yang memiliki 5 operator. Penelitian ini dilakukan selama 6 hari kerja dengan pengamatan selama 7 jam kerja per hari dan data yang akan diambil yaitu denyut nadi operator sebelum mulai kerja, setelah mulai kerja, istirahat kerja dan sesudah selesai kerja. Beban kerja yang di ukur adalah beban kerja fisik. Beban kerja fisik diukur menggunakan cardiovascular load (CVL). Adapun hasil dari persentase cardiovascular load (% CVL) yang diterima setiap operator di stasiun boiler dalam perhitungan %CVL terhadap operator di stasiun boiler diatas, 3 operator di stasiun boiler yaitu Halim Bako, Wito dan Edi Sanjaya mengalami beban kerja fisik yang termasuk dalam kategori tidak terjadi kelelahan pada operator sedangkan 2 operator lainnya yaitu Suroto dan dedi freato mengalami beban kerja fisik yang termasuk dalam kategori memerlukan perbaikan dengan nilai yang didapat yaitu 33.14% (CVL 30% s/d < 60%) dan 31.15% (CVL 30% s/d <60%).
RELATIONSHIP BETWEEN SERUM IRON AND CHARACTERISTICS SOCIAL POPULATION IN PATIENTS WITH HELICOBACTER PYLORI INFECTION
Authors: Huynh Phuong Duy , Ly Khanh Linh 
Published: October 2022

The objective of the study is to investigate the value of serum iron index in patients infected with Helicobacter pylori and find out the correlation between serum iron index and sociodemographic characteristics in patients infected with Helicobacter pylori at faculty 2 of University Medical Center Ho Chi Minh City. The study used CLO and HP CIM tests to determine the Helicobacter pylori infection status, and also collected the serum/plasma of the patient after the HP CIM test to investigate the serum iron index. The Stata 14.0 software was used to manage and analyse data, the ANOVA test was used to test for 3 means or more, and the Chi-squared test wasused to test the difference in proportions between groups. The results showed that the serum iron concentration in the patient group was 59,4±42,1 mg/dL lower than the serum iron value in the control group, which was 86,1±32,0 mg/dL (p < 0,001). The results also indicated that the serum iron value in patients infected with Helicobacter pylori decreased as compared to patients without infection, yet the study also found a relationship between age group and geographical factors. This difference is statistically significant with p <0,001, p = 0,001, p = 0,04 and p = 0,001.