bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of COX-2 Inhibitors Selectivity on Lipid Profile in Hyperlipidemic and Normolipidemic Type 2 Diabetics
Authors: K. Fakree Najwan , H. Ali Shatha 
Published: March 2022

Development of NSAIDS based on inhibiting cyclooxygenase activity. However, the different physiological consequences arrised by appearance of new drugs with different selectivity to COX-2 enzyme upon their administration with their relevant affects on some cardiovascular risk factors. To study the potential effects of relatively diclofenac and highly specific celecoxib COX-2 inhibitors on lipid profile and serum C-reactive protein in type 2 diabetes, whom have hyperlipidemia to be compared by their effects with normolipidemic patients. A total number of 34 type 2 diabetics (14 normolipidemics and 20 hyperlipidemics) treated with either diclofenac 100mg/day or celecoxib 200mg/day for eight weeks. Analysis of results indicated that diclofenac increased serum triglycerides (TG) whereas; celecoxib group exerted a significant reduction in total cholesterol (TC), triglycerides (TG) levels in hyperlipidemic patients. Normolipidemic diabetics showed a significant elevation in serum total cholesterol, triglycerides and low density lipoprotein-cholesterol (LDL) with significant reduction in high density lipoprotein-cholesterol (HDL) in those treated with diclofenac , whilst those treated with celecoxib exhibited no modification of serum lipids. The results of the present study indicated that the net effect of treatment of hyperlipidemic type 2 diabetics by diclofenac was mostly qualitative as indicated by elevated TG/HDL ratio, to be a marker of atherogenic- small dense LDL particles in diabetics, whereas celecoxib exerted no such effect in this group but produced a beneficial reduction in LDL/HDL ratio. Meanwhile, diclofenac in normolipidemic diabetics exert a significant qualitative and quantitative modulation of their serum lipid components presented by net elevation in both LDL/HDL and TG/HDL ratios. As a conclusion the administration of relatively selective COX-2 inhibitors ( diclofenac ) to normolipidemic type 2 diabetics could adversely affect lipid metabolism by producing undesirable qualitative as well as , quantitative changes in serum lipid components, more than that observed in the hyperlipidemic diabetics.
Key Words: Diabetes, lipid profile, cox-2 selectivity
Microsurgical anatomy and the importance of the petrosal process of the sphenoid bone in endonasal surgery
Authors: Doniz-Gonzalez Ayoze , Vigo Vera , Nunez Maximiliano Alberto , Xu Yuanzhi , Mohyeldin Ahmed , Cohen-Gadol Aaron A. , Fernandez-Miranda Juan C. 
Published: March 2022

OBJECTIVE
The petrosal process of the sphenoid bone (PPsb) is a relevant skull base osseous prominence present bilaterally that can be used as a key surgical landmark, especially for identifying the abducens nerve. The authors investigated the surgical anatomy of the PPsb, its relationship with adjacent neurovascular structures, and its practical application in endoscopic endonasal surgery.

METHODS
Twenty-one dried skulls were used to analyze the osseous anatomy of the PPsb. A total of 16 fixed silicone-injected postmortem heads were used to expose the PPsb through both endonasal and transcranial approaches. Dimensions and distances of the PPsb from the foramen lacerum (inferiorly) and top of the posterior clinoid process (PCP; superiorly) were measured. Moreover, anatomical variations and the relationship of the PPsb with the surrounding crucial structures were recorded. Three representative cases were selected to illustrate the clinical applications of the findings.

RESULTS
The PPsb presented as a triangular bony prominence, with its base medially adjacent to the dorsum sellae and its apex pointing posterolaterally toward the petrous apex. The mean width of the PPsb was 3.5 ± 1 mm, and the mean distances from the PPsb to the foramen lacerum and the PCP were 5 ± 1 and 11 ± 2.5 mm, respectively. The PPsb is anterior to the petroclival venous confluence, superomedial to the inferior petrosal sinus, and inferomedial to the superior petrosal sinus; constitutes the inferomedial limit of the cavernous sinus; and delimits the upper limit of the paraclival internal carotid artery (ICA) before the artery enters the cavernous sinus. The PPsb is anterior and medial to and below the sixth cranial nerve, forming the floor of Dorello’s canal. During surgery, gentle mobilization of the paraclival ICA reveals the petrosal process, serving as an accurate landmark for the location of the abducens nerve.

CONCLUSIONS
This investigation revealed details of the microsurgical anatomy of the PPsb, its anatomical relationships, and its application as a surgical landmark for identifying the abducens nerve. This novel landmark may help in minimizing the risk of abducens nerve injury during transclival approaches, which extend laterally toward the petrous apex and cavernous sinus region.
Granular clinical history and outcome in 51 patients with primary and secondary malignant meningioma
Authors: Maier Andrea D. , Mirian Christian , Haslund-Vinding Jeppe , Bartek Jiri , Guldager Rikke , Møller Søren , Munch Tina N. , Fugleholm Kåre , Poulsgaard Lars , Skjøth-Rasmussen Jane , Ziebell Morten , Eriksson Lars E. , Scheie David , Poulsen Frantz R. , Mathiesen Tiit 
Published: March 2022

OBJECTIVE
WHO grade III meningiomas, also known as malignant meningiomas (MMs), are rare, and the heterogenous clinical course in patients with MM is not well described. To characterize the clinical course of patients with MM, granular clinical data were gathered from 51 patients treated at the Department of Neurosurgery and Radiation Oncology, Rigshospitalet, in Copenhagen, Denmark, between 2000 and 2020.

METHODS
The authors investigated outcome and timing in terms of 1) tumor progression and grade transformation in patients previously diagnosed with WHO grade I or II meningiomas (patients with a secondary MM [sMM]); 2) performance status and complications following surgery; and 3) transition to noncurative treatment and ultimately death. Complications, time between recurrences, and outcome (modified Rankin Scale [mRS] score) for every surgery were analyzed, both malignant and premalignant.

RESULTS
Of the 51 patients, 24 (47%) had an sMM. The time to WHO grade III transformation in the sMM group varied widely (median 5.5 years, range 0.5–22 years), but after transformation to a WHO grade III tumor, patients with an sMM and those with a primary MM (pMM) did not differ significantly in overall survival and cumulative risk of progression. Median overall survival for all 51 patients was 4.2 years (95% CI 2.6–7.2 years). Time from the decision to shift from curative to noncurative treatment until death was 3.8 months and the 30-day mortality rate following surgery was 11.8%. From a cumulative number of 151 surgeries, 10 surgeries were followed by improvement on the mRS, mRS score was unchanged in 70, and it worsened in 71. The MM was the underlying cause of death in 30 of 31 patients who had died at the end of follow-up.

CONCLUSIONS
Together, these findings clearly show a significant morbidity and mortality from the disease itself and from the treatment. These findings warrant studies of prognostic factors for earlier support and adjuvant measures in MM and identify a need for better palliative strategies in this patient group.
الحياة الاقتصادية في بلاد الشام من خلال كتاب معجم البلدان لياقوت الحموي (ت 626هـ- 1228م)
Authors: Al-Tamimi Hussein Kadhim  Khayun 
Published: March 2022

تضمن موضوع البحث الموسوم بـ(الحياة الاقتصادية في بلاد الشام من خلال كتاب معجم البلدان لياقوت الحموي (ت 626هـ- 1228م) عدة مباحث، تناول المبحث الأوّل فيه نبذة مختصرة عن حياة ياقوت الحموي ونشأته ومراحل حياته التي مرَّ بها والمهن التي عملها ورحلاته إلى الكثير من المدن والبلدان وتطور خبراته الجغرافية وشروعه بكتابة معجمه الجغرافي الكبير، موضّحاً هذه المدن والبلدان وأخبارها إلى أنَّ استقر به الحال في مدينة حلب التي توفي فيها بعد انجاز كتابه المعروف (معجم البلدان).
أمَّا المبحث الثاني الذي تضمن بلاد الشام من حيث التسمية والموقع والحدود استناداً إلى ما ذكره ياقوت الحموي معززاً بما ذكره المؤرخون عن أصل التسمية وتوضيح مفهوم بلاد الشام، وتحديد الموقع من الأقاليم السبعة التي ذكرت وبيان حدود ومساحة بلاد الشام التي أشار إليها ياقوت الحموي.
في حين تطرق المبحث الثالث إلى محور البحث الذي يتناول الحياة الاقتصادية لبلاد الشام، بما فيها الموارد المائية ومصادرها وأهميتها للأنتاج الزراعي، مبيناً أهم أنواع المحاصيل وفي المقدمة منها زراعة الحبوب المختلفة وأشجار الفواكه والبساتين المنتشرة في عموم بلاد الشام، كما تناول المبحث المقومات الصناعية وأهم الصناعات التي أشار إليها ياقوت الحموي في سياق كلامه عن مدن ومناطق بلاد الشام المختلفة، فضلاً عن التجارة التي لها أسواق رائجة في داخل بلاد الشام وخارجها، وكذلك الإشارة إلى طريق المواصلات والخانات وأهميتها في الحياة الاقتصادية التي عاصرها ياقوت الحموي وخصوصاً الطرق الداخلية تي تربط المدن الشامية مع بعضها البعض والطرق الخارجية التي تُعَدُّ حلقة وصل بين الشرق والغرب والتي تربط بلاد الشام مع البلدان الأخرى والتي أدت بالنتيجة إلى ازدهار الحياة الاقتصادية والتي انعكست إيجاباً على الحياة الاجتماعية والمالية للدولة والمجتمع.
أثر النوع في إدراك الأطفال لحقوقهم وواجباتهم في مجتمع الامارات
Authors: Alteneiji Noura Mohamed , Alomosh Ahmad Falah 
Published: March 2022

تسعى هذه الدراسة على التعرف على أثر النوع في إدراك الأطفال لحقوقهم وواجباتهم في مجتمع الامارات، وذلك عن الطريق مدى الوعي لحقوقهم والمتمثلة في مجالات التالية وهي: حق التعليم وحق الحماية وحق الصحة، وحق الطفل بشكل عام.
وقد تم تصميم استبانة موجة للأطفال في مدارس إمارة الشارقة والذين تتراوح أعمارهم من 12-18 سنة وتم تطبيقها على طلبة والعدد الكلي 270 (80 طالب و190 طالبة) من خلال استخدام طريقة العينة غير الاحتمالية (الغرضية).
وكشفت نتائج الدراسة أثر النوع في مدى معرفة الأطفال من الجنسين لحقوقهم وواجباتهم في حق التعليم، وحق الحماية، وحق الصحة، وحق الطفل بشكل عام، لوجود هناك دلالات إحصائية لكل حق وأن الذكور لهم النصيب الأكبر عن الإناث في معرفة حقوقهم.
المشكلات الاجتماعية للمتقاعدين العسكريين في إمارة دبي
Authors: Altamimi Noora Ahmed , Al-Madani Khalil 
Published: March 2022

هدفت هذه الدراسة إلى التعرف على أهم المشكلات الاجتماعية التي يعاني منها المتقاعدون العسكريون في إمارة دبي، وذلك من خلال تحديد أهم المشكلات الإجتماعية للمتقاعدين العسكرين من عينة البحث، وقد حاولت الدراسة الإجابة على التساؤلات التالية:1- أهم المشكلات المتعلقة بالجانب الاجتماعي لدى المتقاعدين العسكريين في إمارة دبي ، 2- أهم المشكلات المتعلقة بالجانب الاقتصادي لدى المتقاعدين العسكريين في إمارة دبي، 3-أهم المشكلات المتعلقة بالجانب الصحي لدى المتقاعدين العسكريين في إمارة دبي،4-نظرة المتقاعد العسكري في إمارة دبي نحو إمكانية الإفادة من خبراته العلمية والعملية بعد التقاعد.ولتحقيق هذه الأهداف تم تطبيق منهج المسح الاجتماعي، من خلال الاستبيان الذي طبق على عينة غرضية تكونت من (151) مبحوثا من المتقاعدين العسكريين في إمارة دبي ، بالاضافة للمقابلات المعمقة مع 10 متقاعدين عسكرين من إمارة دبي.
وقد أظهرت نتائج الدراسة إلى أن غالبية أفراد العينة من الذكور الذين لم يتجاوزا الخمسين عاما، ولم يتعدوا المرحلة الثانوية في تعليمهم، وأسباب التقاعد جاءت مرتبة كالتالي: بلوغ مرحلة التقاعد، ثم الأسباب الصحية، ثم التقاعد المبكر برغبة شخصية. كما كشفت نتائج الدراسة بأن المتقاعدين العسكريين في إمارة دبي يعانون من مشكلات متعددة منها :أولاً المشكلات الاجتماعية: الخلافات الأسرية ازدادت بعد التقاعد، وزيادة وقت الفراغ المبحوث بعد التقاعد، وعدم التحاقه بعضوية ناد رياضي أو اجتماعي. ثانياً المشكلات الاقتصادية والمتمثلة في :عدم كفاية راتب التقاعد لقضاء حاجة المتقاعد وحاجة أسرته الضرورية، وأن ابناؤهم العاملون لا يساهمون في الإنفاق على الأسرة، وانهم اضطروا إلى الاستدانة من البنك بعد التقاعد، ثالثاً المشكلات الصحية والمتمثلة في: حالتهم الصحية ازدادت سوءا بعد التقاعد، والمعاناة من مرض مزمن.
Anti-allergic activity of an ethanol extract of bunching onion (Allium fistulosum), a traditional vegetable from Osaka
Authors: Jippo Tomoko , Kobayashi Yuko , Kitada Kousuke , Koji Kitsuda 
Published: March 2022

Introduction: The incidences of allergic diseases such as allergic rhinitis, atopic dermatitis, asthma, and food allergies are rising in developed countries. Mast cells play critical roles in various biologic processes related to allergic diseases, including expressing the high-affinity receptor for immunoglobulin (Ig) E on their surface. The interaction of multivalent antigens with surface-bound IgE causes the secretion of granule-stored mediators, as well as the de novo synthesis of cytokines. These mediators and cytokines precede the development of allergic diseases. In Osaka Prefecture, Japan, certain locally cultivated crops have received ‘Naniwa-yasai’, a designation that certifies the significance of traditional vegetables in supporting Osaka’s agriculture and cuisine for over a century. In this study, we investigated the anti-allergic effects of four traditional vegetables from Osaka.Results: The anti-allergic activity of extracts made from Tanabe radish, Moriguchi radish, bunching onion (Allium fistulosum), and mizu eggplant were examined. Various concentrations of each extract were added to RBL-2H3 mast cells prior to stimulation with the calcium ionophore A23187. β-hexosaminidase release was markedly and dose dependently decreased in mast cells following the addition of A. fistulosum, demonstrating its anti-allergic activity. None of the other vegetables had an anti-allergic effect on RBL-2H3 cells.Conclusion: An Osakan traditional vegetable, bunching onion (Allium fistulosum), exhibited anti-allergic activity, and should be explored further as a possible treatment for allergic diseases.Keywords: mast cell, anti-allergy, traditional vegetables, bunching onion (Allium fistulosum)
Rheology of saliva in health and disease
Authors: Rereddy S.K. , Cao A.C. , Blackwell B. , Poling-Skutvik R. , Arratia P.E. , Mirza N. 
Published: March 2022

BACKGROUND: Saliva is a complex fluid that lubricates the oropharynx and facilitates chewing, swallowing, and vocalization. Viscoelasticity is critical for the ability of saliva to fulfill these functions. Xerostomia, or a sensation of dry mouth, occurs in 17–26% of the population. Although many equate xerostomia with hyposalivation, high-risk patients frequently report oral dryness in the absence of decreased salivary flow. OBJECTIVE: This study aims to determine if xerostomia is associated with alterations in the rheological properties of saliva in addition to decreased salivary production. METHODS: The study population included patients with post-radiation xerostomia, patients with anticholinergic-induced xerostomia and healthy controls. Salivary volumetric flow rate was measured, shear viscosity was measured using oscillatory rheometry, and extensional viscosity was measured using capillary thinning methods. Groups were compared using descriptive statistics and univariate analysis. RESULTS: A total of 36 subjects were included: 15 with post-radiation xerostomia, 9 with anticholinergic-induced xerostomia and 12 controls. Salivary volumetric flow was significantly decreased in post-radiation and anticholinergic-induced patients compared to controls. On capillary thinning testing, saliva from xerostomia patients had significantly greater extensional viscosity compared to controls. However, saliva from the three groups showed no significant difference in the complex viscosity or the storage or loss modulus of saliva with oscillatory rheology. CONCLUSIONS: Xerostomia is associated with decreased salivary volumetric flow and quantitative changes in the rheologic properties of saliva.
The Effect of Metformin on Bladder Cancer Incidence and Outcomes: A Systematic Review and Meta-Analysis
Authors: van Hattum Jons W. , de Ruiter Ben Max , Oddens Jorg R. , de Reijke Theo M. , Wilmink Johanna W. , Molenaar Remco J. 
Published: March 2022

BACKGROUND: Effective oral treatment options for urothelial bladder cancer (BC) are lacking. Metformin, the most frequently used oral drug in type II diabetes mellitus, has putative anticancer properties and could, therefore, influence BC incidence and treatment outcomes. We systematically reviewed the current literature regarding the effect of metformin on BC incidence and oncological outcomes in non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). METHODS: This review was conducted according to the PRISMA guidelines. Literature was gathered through a systematic search in PubMed/Medline, EMBASE and the Cochrane library. Risk of bias was determined using the Cochrane risk-of-bias tool for randomized trials and the Newcastle-Ottawa Scale for non-randomized trials. Hazard ratios (HRs) were extracted and pooled in a random-effects meta-analysis. RESULTS: We reviewed 13 studies, including 3,315,320 patients, considering the risk of developing BC after metformin exposure and 9 studies, including 4,006 patients, on oncological outcomes of patients with BC. Metformin did not affect BC incidence (HR 0.97, 95% CI 0.87 –1.09) or oncological outcomes for NMIBC but did show a reduced risk of recurrence (HR 0.52, 95% CI 0.32 –0.84), cancer-specific mortality (HR 0.58, 95% CI 0.43 –0.78) and overall mortality (HR 0.66, 95% CI 0.47 –0.92) in MIBC. CONCLUSIONS: The role of metformin in the prevention and treatment of BC in patients remains unclear. Although a beneficial effect of metformin on treatment outcomes of certain stages of BC may exist, a definitive conclusion cannot be drawn. Prospective clinical trials are needed to assess the efficacy of metformin for BC treatment.
Selection of the calculated equivalent of the supporting devices of U-shaped frames of earthmoving vehicles
Authors: Gorbatyuk Ievgenii , Komotska Svitlana , Mishchuk Dmitry , Volianiuk Vladimir 
Published: March 2022

The article describes the choice of the design equivalent of the supporting devices of U-shaped frames of earthmoving vehicles. When calculating the U-shaped frames of earth-transport machines for the action of forces located in the plane of the frame, the supporting devices must be represented and calculated either as hinged-fixed supports or as a statically defined system.
The difference in the choice of the calculated equivalent of the supporting devices leads to an is-total difference in the estimated load of the entire frame. Considering the same frame with the same load, but with different resistance devices, it is easy to reconcile that the value of the largest bending moment in the transverse part of the raw can vary by 30-35%. A significant difference in load exists in the longitudinal parts of the frame. In this regard, there is a need to formulate the criteria by which it can be concluded that the supporting frame device that is designed corresponds to the calculated equivalent.
The correct choice of the calculated equivalent of the supporting devices of the ground-transport machine frame significantly affects the results obtained during calculations and helps to greatly simplify them.
ANALISIS STRUKTUR GEDUNG TAHAN GEMPA DENGAN METODE SISTEM GANDA (DUAL SYSTEM)
Authors: Hendra Hendra , Zulkarnaen Lio Varan , Rosanti Indah , Ariyansyah Rona 
Published: March 2022

Most parts of Indonesia are earthquake prone areas with medium and high intensity. In the process of constructing the building, it needs to pay attention to several aspects. One of it is the effect of the earthquake. Earthquakes always attack the joint structure so that the structure needs to be designed using the moment-bearing frame system method with the concept of strong columns and weak beams combined with shear walls, so that the building can muffle earthquake vibrations. The building of Lidra Hotel, located on Raya Sedau Street, Samudera Indah beach, Sungai Raya Kepulauan sub-District, Bengkayang Regency, West Kalimantan Province. The building consists of 17 floors with a height of 67 meters from the ground, reinforced concrete structure. Based on the results of the Standard Penetration Test, this building will be builded on medium ground (SD site class) and included in the Seismic Design Category (KDS) D, then the calculation of this building uses the Special Moment Resistant Frame System (SRPMK) combined with a shear wall, so it is called the Dual System Method. Earthquake load planning uses the 2017 Indonesia Earthquake Map using the spectrum response method according to SNI 1726-2019. Calculation of loading according to SNI 1727-2020 and PPPURG 1987, structural concrete requirements for buildings according to SNI 2847-2019, calculation of structural steel roof according to SNI 1729-2020. Based on the calculation of the roof some results were obtained the size of the column and the truss size IWF 148.100.6.9mm, CNP gording 150.50.20.3,2mm, 1 type of plate 130mm; 2 types of beams 350mm/700mm and 300mm/600mm; 4 types of columns, K1 1200mm x 600mm, K2 800mm x 800mm K3 1000mm x 500mm, and K4 700mm x 700mm; 1 type of shear wall 300mm; ladder plate and balustrade 130mm; 4 types of foundation 3600mm x 3600mm x 700mm – spun pile 9 D 600mm; 1500mm x 1500mm x 400mm – spun pile 4 D 350mm; 3000mm x 3000mm x 500mm – spun pile 9 D 500mm; 7600mm x 5600mm x 1000mm – spun pile 12 – 800mm.
MARIA EMERENSINA TAHU UPAYA PEMERINTAH DALAM PENANGANAN PERDAGANGAN ILEGAL DI WILAYAH PERBATASAN NKRI DAN RDTL SEGMEN MOTAMASIN KABUPATEN MALAKA TAHUN 2015 - 2017
Authors: TAHU MARIA EMERENSIANA 
Published: March 2022

Penelitian ini pada dasarnya merupakan suatu studi penelitian kelembagaan pada organisasi pemerintahan di dalam sistem pemerintahan negara. Pilihan terhadap studi penelitian kelembagaan dikarenakan berbagai temuan-temuan dan kajian terhadap organisasi-organisasi tersebut kurang maksimal.
Metode penelitian yang digunakan adalah metode deskriptif kualitatif. Teknik pengumpulan data yakni observasi dan wawancara. Hasil penelitian menunjukan bahwa upaya pemerintah sebenarnya sudah dilaksanakan dengan baik namun belum optimal. Belum optimalnya upaya pemerintah ini disebabkan oleh beberapa faktor penghambat yaitu antara lain: faktor minimnya sarana prasarana penunjang, kawasan perbatasan yang belum dikelola dengan baik dan belum adanya konsep pembangunan yang jelas, komprehensif dan integratif, serta minimnya dorongan aktivitas ekonomi membuat hampir sebagian besar daerah perbatasanbelum optimal, sehingga mengakibatkan terjadinya perdagangan ilegal.
Dengan demikian disimpulkan bahwa upaya pemerintah pada hakekatnya sangat dibutuhkan dalam pembangunan dan perkembangan suatu Bangsa dan Negara. Upaya pemerintah adalah suatu keputusan yang diambil oleh pemerintah dalam melakukan sesuatu atau tidak melakukan untuk tujuan tertentu. Alternatif solusi dalam penyelesaian masalah di perbatasan, disarankan agar pihak pemerintah dapat berkoordinasi dengan instansi terkait dalam hal pemenuhan sarana pasar sebagai pasar perbatasan dan meningkatkan pengamanan perbatasan sehingga perdagangan ilegal dapat diminimalisir di wilayah perbatasan NKRI-RDTL Motamasin Kabupaten Malaka.
PENERAPAN APLIKASI WEB UNTUK ADMINSTRASI DI DESA SIDOSARI LAMPUNG SELATAN
Authors: Sembiring Jaka Persada 
Published: March 2022

Correspondence services and civil registration of the population are very important in village administration. In this case, Sidosari village provides services including correspondence services and population registration for the Sidosari village community. Based on interviews with representatives of village staff that have been carried out at the Sidosari village office, they said that there are several shortcomings in the service section at the Sidosari village office, one of which is the correspondence service and population registration which is done manually. In this case the correspondence service is done manually causing data and letters that have been made difficult to find and frequent data loss occurs. This website is expected to be a tool for employees in carrying out their duties to serve and record population in Sidosari village, South Lampung. Keywords: Administration, Village, Website.