bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic interaction mapping highlights key roles of the Tol‐Pal complex
Authors: Tan Wee Boon , Chng Shu‐Sin 
Published: January 2022

AbstractThe conserved Tol‐Pal trans‐envelope complex is important for outer membrane (OM) stability and cell division in Gram‐negative bacteria. It is proposed to mediate OM constriction during cell division via cell wall tethering. Yet, recent studies suggest the complex has additional roles in OM lipid homeostasis and septal wall separation. How Tol‐Pal facilitates all these processes is unclear. To gain insights into its function(s), we applied transposon‐insertion sequencing, and report here a detailed network of genetic interactions with the tol‐pal locus in Escherichia coli. We found one positive and > 20 negative strong interactions based on fitness. Disrupting osmoregulated‐periplasmic glucan biosynthesis restores fitness and OM barrier function, but not proper division, in tol‐pal mutants. In contrast, deleting genes involved in OM homeostasis and cell wall remodeling causes synthetic growth defects in strains lacking Tol‐Pal, especially exacerbating OM barrier and/or division phenotypes. Notably, the ΔtolA mutant having additional defects in OM protein assembly (ΔbamB) exhibited severe division phenotypes, even when single mutants divided normally; this highlights the possibility for OM phenotypes to indirectly impact cell division. Overall, our work underscores the intricate nature of Tol‐Pal function, and reinforces its key roles in cell wall‐OM tethering, cell wall remodeling, and in particular, OM homeostasis.
Intra‐provincial fiscal decentralization, relative wealth, and healthcare efficiency: Empirical evidence from China
Authors: Sun Shuo , Andrews Rhys 
Published: January 2022

AbstractDecentralizing fiscal power to locally elected governments is often regarded as beneficial for public service efficiency. However, questions remain about whether decentralizing fiscal responsibilities work well in countries lacking political decentralization. In China, fiscal decentralization has significantly strengthened the role of local governments in the provision of healthcare services, but evidence of its efficiency effects is scarce. To cast light on this issue, this study investigates the relationship between intra‐provincial fiscal decentralization and the productive efficiency of healthcare services in China. Analysis of panel data for 2006–2017 suggests that expenditure and revenue decentralization from provincial to sub‐provincial governments significantly improves healthcare efficiency. Further analysis suggests that the positive impact of healthcare expenditure decentralization on healthcare efficiency may be stronger in wealthier provinces. These findings have important theoretical and practical implications.
Wirnt von Grafenberg, Wigalois
Authors: Jeep John M. 
Published: January 2022

Abstract
For the first time, the alliterating word-pairs in Wirnt’s von Gravenberg “Wigalois” are completely listed and analyzed, especially in comparison with previous attestations in Old and Middle High German. Thus, the comprehensive history of the alliterating word-pair in German moves into the second decade of the thirteenth century, by which time over 1,500 such pairs are recorded. References to Ulrich’s von Zatzikhoven “Lanzelot,” often considered together with “Wigalois,” are included. Texts thought to be similar do not necessarily reveal a comparable phraseological inventory, while the authors appear to employ a similar strategy of creating new pairings.
Prevalence and predictors of diabetes distress among adults with type 2 diabetes mellitus: a facility-based cross-sectional study of Bangladesh
Authors: Kamrul-Hasan A. B. M. , Hannan Mohammad Abdul , Asaduzzaman Md , Rahman Mohammad Motiur , Alam Muhammad Shah , Amin Mohammad Nurul , Kabir Mohammed Ruhul , Chanda Palash Kumar , Jannat Nadia , Haque Md Zahurul , Banik Sanjoy Ranjon , Hasan Mohammad Jahid , Selim Shahjada 
Published: January 2022

Abstract
Introduction
Diabetes distress (DD) is common and has considerable impacts on diabetes management. Unfortunately, DD is less discussed and frequently underestimated. This study evaluated the prevalence and predictors of DD in adults with type 2 diabetes mellitus (T2DM).

Methods
A cross-sectional study was conducted at several specialized endocrinology outpatient clinics in Bangladesh from July 2019 to June 2020; 259 adults with T2DM participated. Participants’ DD and depression were measured using the 17-item Diabetes Distress Scale (DDS-17) and 9-item Patient Health Questionnaire (PHQ-9), respectively. DDS-17 scores ≥2 and PHQ-9 scores ≥10 were the cutoffs for DD and significant depression, respectively.

Results
The mean (±SD) age of the participants was 50.36 (±12.7) years, with the majority (54.8%) being male; their median (IQR) duration of diabetes was 6 (3–11) years. Among the study participants, 52.5% had DD (29.7% moderate and 22.8% high DD). The prevalence of emotional burden, physician-related distress, regimen-related distress, and interpersonal distress was 68.7, 28.6, 66, and 37.7%, respectively. Depression was present in 40.5%; 28.6% of the participants had DD and depression. The total DDS-17 score was positively correlated with the PHQ-9 score (r = 0.325, p < 0.001). Rural residence (OR 1.94), presence of any diabetic complication (OR 3.125), insulin use (OR 2.687), and presence of major depression (OR 4.753) were positive predictors of DD. In contrast, age ≥ 40 years at diabetes diagnosis (OR 0.047) and diabetes duration of > 10 years (OR 0.240) were negative predictors of DD (p < 0.05 in all instances).

Conclusions
The prevalence of DD in our setting is notably high; DD and depression frequently overlap. Screening for diabetes distress may be considered, especially in high-risk patients.
ВОЗМОЖНОСТИ ВЛИЯНИЯ НА СОЦИАЛЬНЫЕ УСТАНОВКИ В ЦИФРОВОЙ ОБРАЗОВАТЕЛЬНОЙ СРЕДЕ ШКОЛЫ
Authors: Vanina Emilia V. , Petrova Elena G. , Byakova Elena V. 
Published: January 2022

Актуальность темы исследования. Выбор темы обусловлен тем, что на сегодняшний день недостаточно изучены возможности и эффекты целевого влияния цифровых инструментов на социальные установки обучающихся.
Проблема исследования. Ключевой для исследования стала проблема конструирования позитивного педагогического влияния на социальные установки обучающихся через цифровую среду.
Цель исследования. Теоретически обосновать обобщенную модель содержания социальной установки, проанализировать способы влияния на социальные установки (в частности на примере социальной установки, направленной на безопасное поведение в сети Интернет) педагогическими средствами, включенными в школьную цифровую образовательную среду и выявить результативность имеющихся в практике школы инструментов влияния на социальные установки.
Методы исследования. В ходе исследования были использованы следующие научные методы: теоретический анализ, моделирование, эксперимент.
Результаты исследования. В результате моделирования стало возможным на примере социальной установки к объекту «Безопасность в сети Интернет» создать и в пилотном режиме экспериментально проверить технологию конструирования педагогического влияния на социальные установки обучающихся. Ключевыми этапами технологии стали создание теоретической модели, отбор содержания и форм взаимодействия участников образовательного процесса в цифровой среде, создание целевого педагогического инструмента – сетевого квеста.
Выводы исследования. Эксперимент дал возможность сделать вывод о том, что предлагаемая трехкомпонентная модель социальной установки носит универсальный характер и может быть использована при разработке содержания и выборе способов взаимодействия участников образовательного процесса в цифровой среде с учетом влияния на социальные установки обучающихся.
ИДЕИ ИНКЛЮЗИИ ДЛЯ ОБРАЗОВАНИЯ ОДАРЕННЫХ ДЕТЕЙ
Authors: Parts Olga S. 
Published: January 2022

Цель. Данная статья посвящена теме актуальности использования идей инклюзии для образования одаренных детей. В центре внимания автора особые образовательные потребности одаренных детей.
Материалы и методы. Проведенный сравнительно-сопоставительный анализ понятий позволяет понять причины, почему одаренные дети нуждаются в инклюзии. Понятие «потребности» означает общие нужды; понятие «образовательные потребности» подчеркивает значимость общего образования для развития одаренного ребенка; понятие «особые образовательные потребности» раскрывает специфику одаренных детей, требующей инклюзии для преодоления дефицитов.
Результаты и их обсуждение. В статье обращается внимание на социально-психологическую обусловленность инклюзии: проявление одаренности у ребенка сопровождается особенностями, которые вызывают неприятие в обществе и трудности социальной адаптации. Обосновано, что инклюзивное образование должно быть обязательным компонентом общего образования, поскольку инклюзия необходима для направленного «включения» одаренного ребенка в различные виды активности, получения опыта самостоятельного действия, взаимодействия и коммуникации со сверстниками и взрослыми.
Область применения результатов. Делается вывод, что возможно использовать ресурсы инклюзивного образования в обучении одаренных детей. Современная российская школа нуждается в теоретико-методологических разработках применения идеи инклюзии для образования одаренных детей.
Nonel approaches in the field of gastric cancer surgical treatment
Authors: Kirkilevsky S. , Polyasny V. , Mashukov A. , Kovalevskaya L. 
Published: January 2022

The aim of the study: to estimate the impact of different cellular phenotype of gastric tumors on the survival of patients treated according to standard protocols.
Object and methods of research.The work presents the results of a study conducted on the basis of two medical institutions - the National Cancer Institute and the abdominal oncology and surgery department of the Odessa Regional Oncology Center. 221 patients underwent surgery for gastric cancer (GC) in the period 2007-2013. The average age of patients was 60.88 ± 10.5 years, men - 180, women - 41. Of the total number of operated, 143 patients underwent surgery in the amount of gastrectomy, 78 - subtotal distal resection.
Results. All patients included in the study underwent radical surgery. Tumors removed during surgery were examined using histological, cytological, immunohistochemical methods and genetic tests. The obtained results are monitored for the presence/absence of clinical parallels and mathematical correlations. It was concluded that some combinations of immunohistochemical (IHC) markers were effective in separating groups of patients with different biology of gastric cancer.
Conclusions. Performing more advanced operations (including the use of D2 lymph dissections) is the most effective option for surgical treatment of microsatellite-unstable and Epstein-Barr virus-associated gastric cancer.
Analysis of Characteristics of Plastic Zone and Mechanical Properties of Anchor Structure in Hydraulic Tunnels with High Ground Temperature
Authors: Huang Yuhang , Jiang Haibo 
Published: January 2022

In order to explore the characteristics of plastic zone and the mechanical properties of anchor structure during the construction of hydraulic tunnels with high ground temperature, the high-temperature section of the diversion tunnel of a hydropower station in Xinjiang was studied. Based on the temperature data and the axial force data of the bolt on-site, the Drucker-Prager constitutive model and the finite element method were adopted to simulate and analyze the temperature-stress coupled field and the initial anchoring support during the construction of the high ground temperature tunnels. The results showed that, after the excavation of the tunnel, a crescent-shaped plastic zone first appeared at the hance, then expanded to the spandrel and vault, and finally formed an irregular ring-shaped plastic zone around the tunnel. The higher the initial temperature of surrounding rocks, the larger the plastic deformation and the range of the plastic zone. When the temperature exceeded 80∘∘C, the plastic zone was more likely to expand to the spandrel and vault; and meanwhile, when the bolt was closer to the hance, the neutral point was closer to the cavity wall. As the stress was released, the neutral point moved from close to the cavity wall to away from the cavity wall. Anchoring support can effectively limit the development of plastic zone in surrounding rocks under high ground temperature. After 10 days of anchoring support at 60∘∘C, 80∘∘C, and 100∘∘C, the range of the plastic zone decreased by 9%, 20%, 24%, respectively, and the maximum axial force of a single bolt was 19.4 kN, 20.1 kN, and 23.8 kN, respectively. The higher the temperature, the higher the strength of the bolt.
Extraction and Separation of Overlapped Squamous Cell Cytoplasm with Disjoint Nuclei in Cervical Pap Smear Image
Authors: Deepa T. P. , Rao A. Nagaraja 
Published: January 2022

The automated analysis of Papanicolaou (Pap) smear images is a challenging issue due to the occlusion of cells. The feature extraction and interpretation depend on the accuracy of cell segmentation. This is important to find the difference between normal and abnormal cells. However, most of the time complications are due to overlapping in the Pap smear cells. The overlapping can be in nuclei regions or cytoplasmic regions or sometimes both the regions. There are two types of cells found in Pap smear images – Columnar and Squamous cells. Most of the time abnormalities are found in squamous cells which in turn may lead to cervical cancer. Hence, this work concentrates on the separation of squamous cells in which cytoplasmic regions are overlapped with disjoint nuclei regions. The main objective of this work is to identify the intersecting points where cytoplasmic regions of two cells meet, called Concavity points, which are calculated using a scope of points along the cytoplasmic boundary of the cells, and separating the cells along with these concavity points.
Title: The Impact of Food Self-Sufficiency on National Economy in West Africa: Case of the Republic of Guinea
Authors: Kourouma Kandas , Junaid Dr. , Diallo Aissata 
Published: January 2022

This study examines in the impact of food selficiency on national economy in West Africa particular case Guinea, the major problems of populations needs is food selficiency in Africa. However ; to achieve the self-sufficiency the authorities encourage its production to provide income for Producer, for domestic consumption and for a net exporting country. Local food production remains highly competitive with imported food. In addition, food insecurity across the country is a major development issue that threatens health, productivity and often the survival of the population. This study helps overcome developmental problems due to food selficiency, therefore, the main objective of this study is to analyze the impact of food production in the country and to examine more closely the relationship between food production and national economy on the domestic market. The study used a linear logarithmic model with the exchange rate output as a dependent variable and the food import, inflation rate, umemployment rate, interest rate and population growth. The current results found that imported food is positive sign, supporting the argument that imports products as viable income-generating activity. The self-sufficiency rate is 94%, with strong imports from imports countries, any exports. However, in order to control an national economic income and till increase agriculture production, the government should be able to purchase the food crops production from populations employment to the farmers and then sell them to projects in place for reduce food importation between international, regional and national domestic production along the markets. The development of the national economy Sectors and reduction of poverty and hunger, in particulary growing selficiency of food Security in Guinea.
The International business environments of franchising in BRICS economies
Authors: SAYL ZINEB 
Published: January 2022

This article aims to analyze the factors that explain the growth and success of the franchising in BRICS economies, and study the long-term relationship between determinants and impacts of franchising in these economies.
We propose a panel data regression model for determining the factors affecting the franchising market in BRICS economies. The model is designed for the time period of 2000-2019. We use a Granger causality to study the long-term relationship between determinants and impacts of franchising.
The Results suggests that the development of franchising in BRICS economies is determinated by economic, social, political and legal factors. On the one hand GDP per capita and degree of International competitiveness has a positive impact on franchise, so the purchasing power and the level of individual income affect franchising investment. On the other hand, the market size and level of urbanization have an important impact on franchising investment. Although, there is evidence of interactions between determinants and impacts of franchising in BRICS economies.
Adaptación del cuestionario de personalidad resistente en población mexicana
Authors: Meda-Lara Rosa Martha , Yeo-Ayala Carmen , Juárez-Rodríguez Pedro , Palomera-Chávez Andrés , Moreno-Jiménez Bernardo 
Published: January 2022

Introducción: El concepto de personalidad resistente tal como lo propone Kobasa queda definido por tres dimensiones, a saber: compromiso, control y reto. Moreno-Jiménez y cols., (2014) diseñaron y validaron el Cuestionario de Personalidad Resistente (CPR) en trabajadores españoles y este instrumento se ha adaptado y validado en diferentes países latinoamericanos; sin embargo, en México no se validado psicométricamente.
Objetivo: El objetivo de este estudio fue analizar las propiedades psicométricas de la adaptación del CPR en adultos mexicanos.
Metodología: Se contó con una muestra no aleatoria de 357 adultos que reportaron estar sanos. Se adaptó el CPR a la forma de enfrentar la vida cotidiana.
Resultados: En el análisis factorial confirmatorio se estimaron tres modelos, de ellos el que mostró mejores índices de ajuste fue el trifactorial (control, implicación y reto) con un factor de segundo orden (personalidad resistente), la consistencia interna del CPR fue aceptable y la validez de constructo indicó correlaciones positivas de las dimensiones del CPR con las variables positivas y correlaciones negativas con variables de ansiedad y disfunción social.
Conclusiones: Los resultados encontrados indican que el CPR tiene características psicométricas satisfactorias y que puede utilizarse para medir personalidad resistente (reto, control e implicación) en adultos mexicanos.
Characterisation of ZnO nanoparticles prepared using aqueous leaf extracts of Chromolaena odorata (L.) and Manihot esculenta (Crantz)
Authors: Essien Enobong R. , Atasie Violette N. , Nwude Davies O. , Adekolurejo Ezekiel , Owoeye Felicia T. 
Published: January 2022

Plant-mediated routes for synthesising metal oxide nanoparticles are gaining tremendous attention due to the benefits of the technique: simplicity, cost-effectiveness, and eco-friendliness. We compared the properties of zinc oxide nanoparticles (ZnONPs) made from aqueous leaf extracts of Chromolaena odorata and Manihot esculenta, both of which are abundant on the African continent. The phytochemical composition of the extracts was first assessed using gas chromatography-mass spectrometry (GC-MS) to determine the types of biomolecules involved in the reducing and capping processes that result in ZnONP formation. After that, UV-Vis spectrophotometry, scanning electron microscopy, energy dispersive X-ray analysis, transmission electron microscopy, X-ray diffractometry, and Fourier transform infrared spectroscopy (FTIR) were used to study ZnONP formation, morphological characteristics, elemental composition, shape and size properties, and phase composition. The ZnONPs made with Chromolaena odorata leaf extract had a better distribution of spherical and hexagonal forms, with an average particle size of 42.35 nm. The ZnONPs made with Manihot esculenta leaf as a reductant had a particle size of 14.71 nm on average and were more agglomerated with poor particle distribution. Phytosterols were shown to be the most important biomolecules in the reduction and capping reactions, according to GC-MS and FTIR analyses. In this study, we created a cost-effective technique for the synthesis of eco-friendly ZnONPs for diverse applications, particularly in Africa, using Chromolaena odorata and Manihot esculenta leaves.Significance:

This study could provide useful information on how the phytochemicals embedded in Chromolaena odorata and Manihot esculenta could influence the properties of the ZnONPs obtained from them.
Differences in morphology and formation yield of ZnONPs are obtainable from aqueous leaf extracts of Chromolaena odorata and Manihot esculenta.
Chromolaena odorata and Manihot esculenta could serve as dependable raw materials for the green synthesis of ZnONPs in Africa.
Saponins-uptake and Targeting Issues for Brain-specific Delivery for Enhanced
Cell Death Induction in Glioblastoma
Authors: Suresh P.K. 
Published: January 2022

Abstract:
Saponins represent a category of diverse, natural glycoside molecules that belong to the triterpenoid or the steroid class. They vary in terms of their solubility and permeability characteristics and are classifiable based on the biopharmaceutics classification system. They have drug delivery potential as surfactants that can solubilize cholesterol in the plasma membrane of tumorigenic cells. Glioblastoma is an important malignancy that can aggressively afflict the brain of humans with a poor prognosis. Glioblastoma Stem Cells (GSCs), are an important subset of cancer cells and are major determinants for drug resistance and tumour relapse. These cells are quiescent and have been known to survive current therapeutic strategies. Certain saponins have shown potential to eliminate glioblastoma cells in a variety of model systems and hence provide a sound scientific basis for their development as a “stand-alone” drug or as part of a drug combination (from the existing arsenal of drugs) developed for the treatment of glioblastoma. However, due to their reactogenicity towards the immune system and hemolytic potential, selective delivery to the tumorigenic site is essential. Hence, nano-formulations (liposome/emulsion-based delivery systems/nano-structured lipid and calix[n]arenes-based carriers) and variants that are resistant to saponin may serve as delivery tools that can be functionalized to improve the selectivity. It is necessary to develop/validate/refine in vitro higher order models that replicate the features of the glioma microenvironment (BBB/BTB). Reproducible validation of the model as well as the drug/delivery system will help in the development of formulations that can augment cell death in this recalcitrant brain tumour.
Severe Lower Gastrointestinal Bleeding Due to Choriocarcinoma with
AVM to the Ileum: A Case Report
Authors: Hasanzadeh Malihe , Jahani Najmeh , Khoroushi Farzaneh , Sharifi Nourieh 
Published: January 2022

Background:
Choriocarcinoma and other placental tumors are rare, and metastasis to the gastrointestinal, especially the small bowel, is extremely rare. Furthermore, about 5% of all metastasis belongs to the GI tract.

Case Presentation:
We reported an 18 -year-old patient with severe GI bleeding. Serum BHCG level was 57322 mIU/mL. CT angiography and Pelvic MRI suggested a metastatic arteriovenous malformation to the small bowel. In surgery, we detected the AVM from the right side of the uterus to the ileum, and pathological findings confirmed the choriocarcinoma with metastatic AVM to the ileum.

Conclusion:
Chemotherapy started after surgery, and the patient was asymptomatic on follow-up after 14 months. The results showed that GTN was a differential diagnosis when patients are referred with these signs and symptoms.

ConclusioN:
Findings from this study suggest a high prevalence of paradoxical VL suppression but not immune CD4 gain in the studied subjects following cART. Larger studies are needed to corroborate these findings.