bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sclerochoroidal calcification associated to breast cancer and parathyroid adenoma
Authors: Boned‐Murillo Ana , Dolores Diaz Maria , El Bakkali Ismael Bakkali , Pérez Rivasés Guillermo , Cisneros Pablo , Núñez Moscarda Eva Josefina , Orejudo Derivas Marta , Ascaso Francisco , Honrubia Grijalbo Ana 
Published: January 2022

AbstractPurposeSclerochoroidal calcification (SCC) is an unusual and poorly recognized ocular condition which is usually presented as an incidental finding in asymptomatic individuals. An exhaustive diagnosis is required as it may be commonly misdiagnosed such as choroidal osteoma, choroidal metastasis, amelanotic choroidal nevus, or lymphoma. It is commonly idiopathic but ophthalmologists should be aware of the possible association with severe ocular trauma and chronic intraocular inflammation, or with abnormal calcium‐phosphorus metabolismMethodsWe report the case of a 78‐year‐old woman with a medical history of breast cancer treated with quadrantectomy followed by adjuvant chemotherapy and radiotherapy, and Letrozole (aromatase inhibitors) for 3 years, which was discontinued when a hypercalcaemia and primary hyperparathyroidism (PHPT) related to a parathyroid adenoma. Oncological follow‐up was negative until during a routine examination prior to a right eye cataract intervention, dilated fundus examination revealed bilateral multiple asymptomatic yellow placoid lesionsResultsThe patient's best‐corrected visual acuity (BCVA) was 20/20 in the right and left eye. Tomography–computed tomography (OCT‐scan), Magnetic resonance imaging (MRI) and Positron emission tomography–computed tomography (18‐FDG PET‐TC) revealed diffuse calcification in the choroid plexus bilaterally as well as calcification in the posterior aspect of both globes with no changes in metabolism at these levels. A SCC secondary to hypercalcaemia and PHPT related to a parathyroid adenoma was diagnosed. She was referred to endocrinology specialist to rule out systemic conditions. As the patient stills refusing surgery, she was treated with Cinacalcet (a calcimimetic) with regular follow‐up in the endocrinology clinic. Dilated fundus examination and OCT are performed periodically. For the time being, the patient remains asymptomatic and the lesion stays stable.ConclusionsAll patients with SCC should be tested for underlying systemic disorders involving abnormal calcium‐phosphorus metabolism to avoid complication or unwarranted intervention resulting from the misdiagnosed as a malignant tumor. Periodic ophthalmology studies are required as well to rule out possible complications.
Correlation between imaging morphological findings and laboratory biomarkers in patients with retinal vein occlusion
Authors: Kazantzis Dimitrios , Theodossiadis Panagiotis , Kroupis Christos , Chatziralli Irini 
Published: January 2022

AbstractPurposeTo investigate the potential association between peripheral blood biomarkers and morphological characteristics of retinal imaging in patients with retinal vein occlusion (RVO).MethodsParticipants in this cross‐sectional observational study were 65 consecutive patients (65 eyes) with treatment naïve RVO, who underwent spectral‐domain optical coherence tomography (SD‐OCT) and fundus fluorescein angiography (FFA). In addition, peripheral blood samples were taken to evaluate full blood count and biochemical parameters. Correlation between imaging characteristics and laboratory parameters was examined.ResultsEyes with subretinal fluid presented significantly higher neutrophil‐to‐lymphocyte ratio (p = 0.028). Hyperreflective foci on SD‐OCT were found to be associated with higher triglycerides (p = 0.024). Presence of cysts on SD‐OCT was associated with significantly higher triglycerides (p = 0.010). Central subfield thickness (CST) higher than 464 μm was associated with higher lymphocyte count (p = 0.016) and higher urea (p = 0.015). No significant associations were found between laboratory parameters and intraretinal fluid, ellipsoid zone and external limiting membrane condition, epiretinal membrane and macular ischemia.ConclusionsSpecific imaging morphological characteristics were found to be associated with laboratory parameters in patients with RVO. These findings may scrutinize the pathophysiology of RVO and its correlation with the development of specific clinical signs, while they could guide individualized treatment.
Patient opinion on the monitoring of their wet age‐related macular degeneration during coronavirus disease 2019 pandemic and on the importance of telemedicine
Authors: Tsiropoulos Georgios N. , Vallée Rodolphe , Calci Coraline , Gallo Castro Daniela , Ambresin Aude 
Published: January 2022

AbstractPurposeTo present the patients’ view on the monitoring of their wet Age‐related Macular Degeneration (wet AMD) during Coronavirus disease 2019 (COVID‐19), and the impact that telemedicine could have on it.MethodsWet AMD patients of Swiss Visio Montchoisi and RétinElysée (Lausanne, Switzerland), who had intravitreal anti‐Vascular Endothelial Growth Factor (anti‐VEGF) injections before and after the first period of the Swiss confinement due to COVID‐19, completed two questionnaires. The first evaluated their view on their adherence to their scheduled injections during the confinement, and on the future use of telemedicine. The second, adapted from National Eye Institute Visual Function Questionnaire‐25, evaluated their opinion on their visual function during the confinement.ResultsFrom a total of 130 patients, 8.5% responded they did not respect their assigned injection interval during the confinement (group 1), while 91.5% responded they did (group 2). The majority of group 1 (37.5%) responded they did not attend their scheduled visit to avoid using public transportation. The majority of group 2 (78.7%) considered the continuation of their treatment more important than the risk of contracting COVID‐19. Before the lockdown, patients of group 2 had more need for help from others than the patients of group 1 (p = 0.02). In a future lockdown, 36.3% of group 1 and 8.7% of group 2 would prefer remote monitoring of their wet AMD via telemedicine (p = 0.02), 54.5% and 86.9% would prefer to visit the clinic (p = 0.02), while 9% and 4.3% would avoid the visit, respectively. 70% of group 1 and 33.6% of group 2 would rather use the telemedicine application in their home than visit a telemedicine center (p = 0.04).ConclusionsDespite our availability to provide continuous intravitreal anti‐VEGF injections during the COVID‐19 confinement, many wet AMD patients did not receive their scheduled treatment. In similar future circumstances, most patients would prefer to visit the clinic. The patients of group 1 would prefer remote monitoring of their AMD via telemedicine at a higher rate than the patients of group 2.Bibliography

Visual Function Questionnaire 25. https://www.nei.nih.gov/learn‐about‐eye‐health/resources‐for‐health‐educators/outreach‐materials/visual‐function‐questionnaire‐25
Outcomes following cataract surgery in patients with age‐related macular degeneration
Authors: Kumar Aneeta , Shalchi Zaid 
Published: January 2022

AbstractPurposeCataract and age‐related macular degeneration (AMD) can occur concomitantly in the elderly population. AMD is often considered a poor prognostic factor for visual outcomes after cataract surgery. We wanted to investigate the outcomes of cataract surgery in patients with AMD.MethodsWe retrospectively analysed pre‐ and post‐operative visual acuity and refraction results for all adult patients who underwent phacoemulsification cataract surgery between February 2009 to May 2021 at a local hospital trust in the National Health Service (NHS), UK. Data collection was done through the Medisoft electronic medical record (Heidelberg Engineering, Leeds, UK). Statistical tests were conducted using paired and unpaired Student t‐tests, and p < 0.05 was considered significant.ResultsIn total, we included 27 357 eyes undergoing cataract surgery in our analysis, of which 1653 had AMD. Patients with AMD underwent cataract surgery at an older age compared to those without AMD (82.2 years vs 74.6 years, p < 0.0001). Pre‐operatively, eyes with AMD tended to be more hypermetropic than healthy eyes and underwent a more substantial change in refractive power following surgery (p < 0.0001). Overall, visual acuity improved for patients post‐operatively, but patients with AMD had poorer improvement in visual acuity than patients with no ocular co‐pathology (LogMAR −0.17 versus −0.29, p < 0.0001). Notably, 23% of patients with AMD had poorer visual acuity post‐operatively, compared to only 10% in patients without any pathology (p < 0.0001).ConclusionsPatients with AMD undergoing cataract surgery showed an improvement in visual acuity, although this improvement is less than in eyes with no co‐pathology. This data will help counsel AMD patients considering cataract surgery.
Comparison of quantitative self‐monitoring metamorphopsia measurements tools in myopic choroidal neovascularization (mCNV)
Authors: Hoffmann Laura , Mueller Susanne , Hatz Katja 
Published: January 2022

AbstractPurposeTo assess the reproducibility and reliability of two self‐monitoring metamorphopsia devices (Alleye, Oculocare medical Inc. and AMD – A Metamorphopsia Detector software (MI), app4eyes GmbH & Co. KG, Germany) for detection of disease activity and inactivity in myopic choroidal neovascularization (mCNV).MethodsParticipants with foveal mCNV were followed over 12 months undergoing a standardized refraction protocol, metamorphopsia assessment, Spectral Domain Optical Coherence Tomography (SD‐OCT) and fundus autofluorescence (FAF) at baseline, 6 months, 12 months and additional individual visits. Disease activity and morphologic parameters were graded based on their location in an Early Treatment of Diabetic Retinopathy (ETDRS) grid overlay. Intraclass correlation coefficients (ICC) between inactive visits were calculated to assess repeatability. Scores of inactive and active visits were compared intra‐individually using paired t‐tests.ResultsTwenty‐one (21) eyes performing a total of 202 tests were included. Disease activity was observed in 14 eyes. ICC between inactive visits were excellent for both devices (0.98; 0.97). Mean difference between the active and inactive scores was more pronounced for the MI with 117.80 ± 231.57 (p = 0.079) than the Alleye score with 0.362 ± 17.16 (p = 0.938) considering all locations. Mean deviation from the mean inactive score was higher for both scores when disease activity was located in the central 1mm (128.70 ± 272.94; p = 0.195 for the MI and −4.42 ± 14.01; p = 0.372 for the Alleye score) compared to in the central 6 mm (70.67 ± 155.16; p = 0.513, respectively 1.43 ± 11.82; p = 0.853).ConclusionsBoth devices yielded reproducible scores for disease inactivity. Disease activity was better captured by the MI especially if subfoveally located. Hence, self‐monitoring devices may complement diagnostic management of mCNV. Data from larger cohorts including home monitoring are warranted.
Results of pars plana vitrectomy with inferior retinotomy in inferior rhegmatogenous retinal detachments with inferior retinal breaks and proliferative vitreoretinopathy grades B or C
Authors: Machado Soares Ricardo , Da Silva Fernandes Joana , Ferreira Catartina , Sousa Neves Filipe , Sepúlveda Paula , Bilhoto Miguel 
Published: January 2022

AbstractPurposeTo report the surgical outcomes of pars plana vitrectomy (PPV) with inferior retinotomy without the need for scleral buckling in primary inferior rhegmatogenous retinal detachment (RRD) with inferior retinal breaks and Proliferative vitreoretinopathy (PVR) grades B or C.MethodsRetrospective, consecutive series, single‐center study of patients that underwent PPV with inferior retinotomy for primary inferior RRD with inferior retinal breaks (4:00 to 8:00 clock hours) and PVR grades B or C. Data were obtained from patients’ medical records from October 2014 to November 2020. The primary outcomes of the study were retinal reattachment and visual acuity improvement. Data collected before and after surgery was compared between groups using chi‐square analysis and paired samples t‐test. The resulting p‐values significance level was set at p = 0.05.ResultsThirty‐two patients (32 eyes) met the inclusion criteria. PVR in stage B was present in 19 patients and stage C in 13 patients. Macula‐off RRD was diagnosed in 25 patients while the other 7 patients had RRD with the macula attached. Regarding primary outcomes, 31 out of 32 (97%) patients achieved retinal reattachment with no differences between PVR groups (p = 0.406). The best‐corrected visual acuity (BCVA) improved significantly in eyes with macula‐off RRD at presentation (p < 0.001). Although macula‐attached RRD eyes had higher final BCVA, its improvement was not statistically significant (p = 0.370). Besides one retinal redetachment, no other significant complications were reported after surgery.ConclusionsInferior retinal breaks are associated with surgical failure following PPV for inferior RRD repair, especially if advanced PVR is present. Our results suggest that, in these less common and more challenging cases, PPV with an inferior retinotomy is associated with very favorable anatomic and visual outcomes.
Clinical features of patients with PEVAC in University Hospital of Canarias
Authors: Tapia Quijada Hugo E. , Falcon Roca Rocio , Sanchez Garcia Mariel 
Published: January 2022

AbstractPurposeTo investigate the clinical characteristics of Perifoveal Exudative Vascular Anomalous Complex (PEVAC) patients diagnosed in the University Hospital of Canarias.MethodsThis retrospective study included 7 eyes (of 7 patients) diagnosed with PEVAC. We reviewed the demographic characteristics. All of our patients had undergone a complete ophtalmological examination including color retinography, autofluorescence, Optical Coherence Tomography (OCT), fluorescein angiography(FA) and OCT‐Angiography (OCTA). We also reviewed the follow‐up information.ResultsOf our 7 patients, 3 were women and 4 were men. The average age and standard deviation were 71.0 +‐12.8 years. Average visual acuity was 0.54 + −0.24.Of our 7 patients, 4 had no remarkable comorbidities, 2 had age‐related macular degeneration and the resting patient had myopic degeneration. PEVAC presented as a big isolated perifoveal aneurysm. On OCT PEVAC appeared as a round hyperreflective lesion, typically surrounded by intraretinal cystic spaces. FA showed a well defined hyperfluorescent lesion with variable leakage. OCTA revealed that the isolated aneurysmatic lesion was located in the superficial capillary plexus in 2 cases; in the deep capillary plexus in 4 cases and in one cases it seemed to be in the intermediate plexus. In 5 cases, there was only subtle exudation that did not require treatment, remaining stable during follow‐up. In two cases, exudation was greater, so we treated them with anti‐VEGF, with partial response.ConclusionsPEVAC is an aneurysmatic isolated perifoveal abnormality that can occur in patients with or without retinal disease. PEVAC did not respond to anti‐VEGF therapy.Bibliography

Querques G, Kuhn D, Massamba N, Leveziel N, Querques L, Souied EH. Perifoveal Exudative Vascular Anomalous Complex. J Fr Ophtalmol 2011; 34(8): 559.e1–4.

Sacconi R, Freund KB, Yannuzzi LA, Dolz‐Marco R, Souied E, Capuano V, et al. The Expanded Spectrum of Perifoveal Exudative Vascular Anomalous Complex. Am J Ophthalmol 2017; 184:137–146.

Mrejen S,Le HM,Nghiem‐Buffet S,Tabary S,Quentel G,Cohen SY. Insights into Perifoveal Exudative Vascular Anomalous Complex. Retina 2020;40(1):80–86.
Measures to assess a warning vaccination level in a stochastic SIV model with imperfect vaccine
Authors: Gamboa Maria , Lopez‐Herrero Mariajesus 
Published: January 2022

AbstractA stochastic Markovian Susceptible‐Infectious‐Susceptible (SIS) model, with infection reintroduction is considered to represent the evolution of an epidemic process within a finite population. Disease is assumed to be a contact disease whose effect can be prevented by a vaccine. Before the epidemic process emerges, individuals got vaccinated to assure that the population is protected by herd immunity. In consequence, we formulate the model by adding a new compartment for vaccine protected individuals. The administered vaccine is not a perfect one and consequently it fails in a proportion of vaccinated individuals that are not protected against the vaccine preventable communicable disease. Hence, while the infectious process is in progress, the initial vaccine coverage declines and herd immunity could be lost. A threshold on the size of the vaccinated group is included as a warning measure on the protection of the community. Our objective is to define and study random characteristics, depending on the vaccination eligible group, that could advise health authorities when to launch a new vaccination program to recover the initial immunity level.
Efficacy and safety of first-line osimertinib treatment and postprogression patterns of care in patients with epidermal growth factor receptor activating mutation-positive advanced non-small cell lung cancer (Reiwa study): study protocol of a multicentre, real-world observational study
Authors: Watanabe Kageaki , Yoh Kiyotaka , Hosomi Yukio , Usui Kazuhiro , Naka Go , Kishi Kazuma , Uemura Kohei , Ohashi Yasuo , Kunitoh Hideo 
Published: January 2022

IntroductionOsimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), is widely used as the first-line treatment for EGFR mutation-positive non-small cell lung cancer (NSCLC). Nevertheless, most cases ultimately acquire resistance to osimertinib, and no effective treatment has been currently established for cases having progressive disease (PD) with osimertinib. In clinical practice, EGFR-TKI therapy could be continued beyond response evaluation criteria in solid tumours (RECIST)-defined PD cases when they are clinically stable. Currently, the progression pattern of osimertinib and criteria for identifying patients who might benefit from osimertinib beyond PD are unknown. In addition, the efficacy and safety of osimertinib as the first-line treatment in real-world clinical practice remain unclear in Japan. This multicentre study was designed to evaluate the real-world data on first-line osimertinib and its post-treatment.Methods and analysisThe study enrols patients with EGFR mutation-positive, advanced or recurrent NSCLC who received EGFR-TKI as the first-line therapy after 1 September 2018, from October 2019 to August 2020, and those started on osimertinib will be followed up until August 2022. We will evaluate the efficacy and safety of the first-line osimertinib treatment, adherence to it, progression patterns on RECIST PD and subsequent treatment.Ethics and disseminationAll participating patients will provide written informed consent before entering the study. The protocol, amendments and patients’ informed consent forms will be approved before study commencement by the institutional review board or independent ethics committee at each participation site (Lead Ethics Committee; Japan Red Cross Medical Center (26 April 2019, order number 976)). Patients will be anonymised before registration into the study and their anonymised data will be collected from the case report form. The results of this study will be presented at the national and international conferences and submitted for publication.Trial registration numberUMIN000038683.
SLEEP: intervention with weighted blankets for children with attention deficit hyperactivity disorder (ADHD) and sleep problems: study protocol for a randomised control trial
Authors: Larsson Ingrid , Aili Katarina , Nygren Jens M , Johansson Pia , Jarbin Håkan , Svedberg Petra 
Published: January 2022

Introduction and objectivesChildren with attention deficit hyperactivity disorder (ADHD) have an increased risk of sleep problems. Weighted blankets are one possible non-pharmacological intervention for these problems in this group of children. However, the effectiveness of weighted blankets is insufficiently investigated. This study aims to investigate the effectiveness of weighted blankets in terms of sleep, health-related outcomes and cost-effectiveness as well as to explore children’s and parents’ experiences of a sleep intervention with weighted blankets.Methods and analysisThis study is a randomised placebo-controlled crossover trial comparing the effect of weighted fibre blankets (active) with fibre blankets without weight (control). Children aged 6–13 years, recently diagnosed with uncomplicated ADHD with verified sleep problems, were included in the study. The study period is 4 weeks for each condition, respectively, and then an 8-week follow-up. A total of 100 children diagnosed with ADHD and sleep problems will enter the study. The primary outcomes are sleep and cost per quality-adjusted life years. The secondary outcomes are health-related quality of life, ADHD symptoms, psychological distress and anxiety. Interviews with a subsample of the participating children and parents will be conducted for exploring the experiences of the intervention.Ethics and disseminationEthical approval of the trial has been obtained from the Swedish Ethical Review Authority (number 2019–-2158) and conforms to the principles outlined in the Declaration of Helsinki (WMA, 2013). Results will be reported as presentations at peer-review conferences, in articles in peer-review journals and meetings with healthcare providers.Trial registration numberNCT04180189.
Prognostic impact of albumin-bilirubin score on the prediction of in-hospital mortality in patients with heart failure: a retrospective cohort study
Authors: Han Su , Wang Chuanhe , Tong Fei , Li Ying , Li Zhichao , Sun Zhaoqing , Sun Zhijun 
Published: January 2022

ObjectivesLiver dysfunction is prevalent in patients with heart failure (HF) and can lead to poor prognosis. The albumin-bilirubin (ALBI) score is considered as an effective and convenient scoring system for assessing liver function. We analysed the correlation between ALBI and in-hospital mortality in patients with HF.DesignA retrospective cohort study.Setting and participantsA total of 9749 patients with HF (from January 2013 to December 2018) was enrolled and retrospectively analysed.Main outcome measuresThe main outcome is in-hospital mortality.ResultsALBI score was calculated using the formula (log10 bilirubin [umol/L] * 0.66) + (albumin [g/L] * −0.085), and analysed as a continuous variable as well as according to three categories. Following adjustment for multivariate analysis, patients which occurred in-hospital death was remarkably elevated in tertile 3 group (ALBI ≥2.27) (OR 1.671, 95% CI 1.228 to 2.274, p=0.001), relative to the other two groups (tertile 1: ≤2.59; tertile 2: −2.59 to −2.27). Considering ALBI score as a continuous variable, the in-hospital mortality among patients with HF increased by 8.2% for every 0.1-point increase in ALBI score (OR 1.082; 95% CI 1.052 to 1.114; p<0.001). The ALBI score for predicting in-hospital mortality under C-statistic was 0.650 (95% CI 0.641 to 0.660, p<0.001) and the cut-off value of ALBI score was −2.32 with a specificity of 0.630 and a sensitivity of 0.632. Moreover, ALBI score can enhance the predictive potential of NT-pro-BNP (NT-pro-BNP +ALBI vs NT-pro-BNP: C-statistic: z=1.990, p=0.0467; net reclassification improvement=0.4012, p<0.001; integrated discrimination improvement=0.0082, p<0.001).ConclusionsIn patients with HF, the ALBI score was an independent prognosticator of in-hospital mortality. The predictive significance of NT-proBNP +ALBI score was superior to NT-proBNP, and ALBI score can enhance the predictive potential of NT-proBNP.