bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of DAP3 as candidate prognosis marker and potential therapeutic target for hepatocellular carcinoma
Authors: Yuan Liu-Xia , Yue Zhi-Qiang , Ma Qin-Rong , Zhang Peng , Xiao Feng , Chen Lin 
Published: February 2025

BackgroundAmong malignant tumors, hepatocellular carcinoma (HCC) is both prevalent and highly lethal. Most patients with advanced-stage liver cancer have a poor prognosis. Death-associated protein 3 (DAP3) is reportedly related to tumors and may hold great promise for the future.MethodsDAP3 transcriptome data along with related clinical information were obtained from The Cancer Genome Atlas (TCGA), GEO, and ICGC databases. We assessed its prognostic value, clinical relevance, associated pathways, immune infiltration, gene mutations, and sensitivity to chemotherapeutics. A prognostic risk model was subsequently developed and evaluated using receiver operating characteristic (ROC) curves and Kaplan-Meier (KM) plots. Additionally, a nomogram was created and validated through calibration and decision curve analysis (DCA). Furthermore, quantitative real-time PCR (qRT-PCR), Western blot, and immunohistochemical (IHC) staining were performed to examine the expression of DAP3 in HCC. Finally, gene knockdown and overexpression experiments, along with cell counting kit-8 (CCK-8) assays, colony formation assays, and tests for cell apoptosis, migration, and invasion, were conducted to investigate the role of DAP3 in HCC.ResultsThe study discovered that DAP3 expression was linked to HCC subtypes, and its high expression was linked to a poor prognosis. There were significant differences in immune infiltration level, mutation level, prognostic value and chemotherapeutic efficacy. Subsequently, we constructed a prognostic model and demonstrated that high risk score was significantly related to a poor survival rate. A predictive nomogram demonstrated that the nomogram model was effective prediction tool that can accurately predict the survival rate of patients with different clinical characteristics. Additionally, DAP3 expression significantly increased in both tissue samples and cell lines. Elevated levels of DAP3 were correlated with larger tumor size and higher alpha-fetoprotein (AFP) levels, and Cox analysis confirmed that DAP3 was a clinically independent prognostic marker. Finally, cell assays revealed that the knockdown of DAP3 significantly impeded cell proliferation and metabolic activity and induced apoptosis. Conversely, the overexpression of DAP3 had opposite effects on these cellular processes.ConclusionsOur study on DAP3 can provide a reference for HCC diagnosis, treatment and prognosis assessment.
Association between inflammatory score, healthy lifestyle, and cardiovascular disease: a national cohort study
Authors: Zhao Han-Qing , Lv Jia-Le , Gao Yuan-Zhi , Hu Bo , Du Zong-Da , Wang Yan , Wang Mei-Lin , Hou Meng-Di , Li Fang , Xing Xue , Sun Ming-Hui 
Published: February 2025

BackgroundThe inflammation score is currently regarded as a reliable composite index for comprehensive assessment of inflammatory status. However, the relationship between inflammation score and cardiovascular disease (CVD) is unclear. Thus, we aimed to explore the association of inflammatory score with CVD, as well as to evaluate whether adhering to a healthy lifestyle could alleviate this association.MethodsWe analyzed 6,164 participants aged ≥45 years who entered a prospective cohort study of the China Longitudinal Study of Health and Retirement (CHARLS) between 2011 and 2012 and were followed up for CVD incidence untill 2018. The inflammatory score was measured by summing of the Z-scores for C-reactive protein and white blood cell count at baseline. The healthy lifestyle score was calculated by four factors, smoking status, alcohol consumption, body mass index, and sleep duration. Cox proportional hazard models were utilized to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of CVD.ResultsDuring the 7-year follow-up period, there were 761 incident cases of CVD. Compared with the lowest tertiles, the highest inflammatory score was associated with an elevated risk of CVD (HR = 1.25, 95% CI = 1.04–1.49). Compared to the unhealthy lifestyle, participants adhered to a healthy lifestyle was inversely associated with CVD risk (HR = 0.74, 95% CI = 0.60–0.93). Of note, when participants adhered to a healthy lifestyle, the higher inflammatory score was no longer significantly correlated with CVD risk (HR = 1.00, 95% CI = 0.76–1.34). Additionally, a multiplicative interaction was detected between inflammatory score and healthy lifestyle score for CVD risk (p interaction &lt;0.05).ConclusionThe inflammation score was associated with higher risk of CVD incidence, but adherence to a healthy lifestyle may mitigate the adverse association of inflammation score and CVD among the middle-aged and older participants.
Targeted treatment and survival in advanced non-squamous non-small cell lung cancer patients – a nationwide and longitudinal study
Authors: Nyen Johanne Elise , Booth Anja Ødegård , Husby Øyvind , Bugge Christoffer , Engebretsen Ingrid , Oteiza Francisco , Helland Åslaug , Fjellbirkeland Lars , Brustugun Odd Terje , Grønberg Bjørn Henning 
Published: February 2025

ObjectivesWe aimed to describe treatment patterns, time on treatment (ToT) and overall survival (OS) for patients with advanced non-squamous, EGFR+, ALK+ and ROS1+ NSCLC in Norway.Materials and methodsWe extracted data on patients ≥ 18 years diagnosed with advanced non-squamous NSCLC between 2015 and 2022 from the Cancer Registry of Norway and data on cancer drug therapy from the Norwegian Patient Registry and the Norwegian Prescribed Drug Registry. ToT was measured from the date treatment was collected or administered until the last dispensing was depleted or last hospital drug administration. OS was measured from date of diagnosis until death.ResultsIn total, 5,279 patients were included, of whom 449 EGFR+, 131 ALK+ and 38 ROS1+. 75% of EGFR+ patients, 88% of ALK+ patients, and 58% of ROS1+ patients received at least one systemic treatment within the first three months after diagnosis. Median follow-up was 13, 19, and 4 months for EGFR+, ALK+, and ROS1+, respectively. The median ToT in first line (1L) for EGFR+ patients was 11 months for osimertinib (CI: 10.1-NA) and 9 months (CI: 8.2-11.2) for afatinib, dacomitinib, erlotinib and gefitinib. For ALK+ patients, median ToT in 1L was 20 months (CI: 14.7-23.7for alectinib, 11 months (CI: 4.7-NA) for brigatinib, and 7 months (CI: 2.9-21.6) for crizotinib. For the five ROS1+ patients treated with crizotinib in 1L, median ToT was 5 months (CI: 2.4-NA). For all patients with a targetable genomic alteration, unadjusted median OS was higher (p-value = 0.025) for patients diagnosed in 2020-2022 (median OS: 23 months, CI: 19.5-NA) compared to patients diagnosed in 2015-2019 (median: 19 months, CI: 16.5-21.2).ConclusionsToT for targeted therapies was shorter than progression-free survival in clinical trials. However, patients eligible for targeted therapy still had a survival improvement during the study period.
Case report: Molecular characterization of adult atypical teratoid rhabdoid tumor and review of the literature
Authors: Hernandez-Rovira Miguel A. , Connor Michelle , Osorio Robert C. , Russler-Germain Emilie , Schmidt Robert , Johnson Gabrielle W. , Silverstein Julie , Dahiya Sonika , Farrell Nyssa Fox , Weiss Mia C. , Zipfel Gregory J. , Huang Jiayi , Mathios Dimitrios 
Published: February 2025

Background and importanceAtypical teratoid rhabdoid tumors (ATRTs) are typically aggressive pediatric tumors with a median survival of 11 months. Due to the paucity of cases in adults, the clinical behavior of these pathologies is not well understood. Here we present the case of a 41-year-old female patient with postoperative hyperprogression of a sellar ATRT and provide a detailed description of the molecular composition of this tumor, the protocol used to treat this patient, and the ultimate outcome of this patient.Clinical presentationThe patient is a 41-year-old woman who presented with headaches and double vision. MRI revealed a sellar/suprasellar mass with involvement of bilateral cavernous sinuses. Following the quick symptom progression, resection of the tumor with exploration of the bilateral cavernous sinuses was performed, with a final pathologic diagnosis of ATRT-MYC, a known subtype of ATRT. The tumor recurred within 1 month of surgery, attaining a size equivalent to its preoperative state. Postoperatively, the patient received craniospinal radiation and adjuvant chemotherapy with an excellent response but had a recurrence of the tumor in the brainstem 1 year after her diagnosis and died 13 months after presentation.DiscussionSellar ATRT in adults is an exceedingly rare entity. The detailed description of our case highlights the aggressiveness of these tumors and the utility of postoperative chemotherapy and radiation, but also the inevitable progression of these tumors along the craniospinal axis.ConclusionSellar ATRTs should be considered in the differential diagnosis of a sellar/suprasellar mass, especially in women in their 40s. Emphasis should be placed on accurate diagnosis and quick postoperative recovery with early initiation of adjuvant radiation and chemotherapy.
Underutilized treatments for patients with refractory cancer pain: a qualitative study assessing the use of intrathecal drug delivery devices in the United Kingdom compared to alternative treatments in cancer pain management
Authors: Barnosky Victoria , Brown Matthew , Bagchi Somnath , Blain Remy , Husejnovic Demir , Johnson Sandra , Mackworth-Praed Meredith 
Published: February 2025

ObjectivesThis research aims to better delineate how intrathecal drug delivery systems (IDDS) are incorporated into the oncology care continuum and highlight the need for further awareness of interventional options for pain management of cancer patients in the United Kingdom. The study focuses on exploring the knowledge, perspectives, and experiences of healthcare professionals regarding IDDS as a treatment option for managing chronic refractory pain in cancer patients.MethodologyA thematic coding using inductive analysis was employed to achieve the research objectives. Semi-structured interviews were conducted with 18 healthcare professionals in various specialties, including oncology, neurosurgery, pain management, and palliative care. The interviews were transcribed, and a two-phased qualitative inductive coding approach was used to analyze the data.ResultsThe findings of the study revealed four major themes: Education, Barriers &amp; Benefits, Technical &amp; Administrative, and Patient-Centered Care. The theme of Education highlighted the need for increased knowledge and awareness of IDDS among healthcare professionals. Barriers &amp; Benefits encompassed concerns about infection risk, suitability for patients with a short life expectancy, and the challenges and advantages of IDDS use. The Technical &amp; Administrative theme addressed cost considerations, device management, and the need for improved guidelines. Patient-Centered Care emphasized the importance of involving patients in decision-making and considering their physical and emotional well-being throughout the treatment pathway.ConclusionsThis research identifies several areas of unmet need in the management of refractory pain in cancer patients, including the development of more inclusive guidelines, greater awareness among clinicians and patients, and the role of medical technology companies in supporting effective pain management. The findings underscore the impact of IDDS on improving pain control and highlight the potential importance of early intervention and comprehensive pain management in influencing the trajectory of oncological diseases.
The psychological resilience of teenagers in terms of their everyday emotional balance and the impact of emotion regulation strategies
Authors: Yu Zengyan , Liu Wen 
Published: February 2025

ObjectiveAdolescents are also more vulnerable to the effects of everyday life stimuli and exhibit a range of negative emotional states that can develop into severe affective disorders. However, Psychological resilience maybe enable the prevention of emotional problems associated with daily stress rather than intervening treating the problem after it has occurred.MethodsA total of 104 individuals (54 participants in the high psychological resilience group and 50 participants in the low psychological resilience group) were first identified. Then, the 8-day experiential sampling method was used to determine the characteristics of adolescents with different psychological resilience levels in terms of emotional balance under daily stress. Further combined with diary method research, a multilayered linear model was used to explore the predictive effects of six emotion regulation strategies on adolescents’ emotional balance.ResultsThe obtained Results show that high psychological resilience adolescents demonstrated higher levels of emotional balance and positive rates and lower rates of change in emotional balance than low psychological resilience adolescents. In terms of facilitating emotion regulation strategies, high psychological resilience was associated with greater use of cognitive reappraisal and social sharing strategies (which positively predicted emotional balance under daily stress) and less use of expression suppression and rumination strategies (which negatively predicted levels of emotional balance).ConclusionAdolescents with high psychological resilience exhibit good adaptive emotional states in daily stressful situations, which is closely related to their use of adaptive emotion regulation strategies such as cognitive reappraisal and social sharing and may be useful for further intervention research.
Factors that influence participation in physical activity in Chinese teenagers: perspective of school educators and parents in respect of the social ecology model
Authors: Hu Donglin , Zhou Shi , Crowley-McHattan Zachary J. , Liu Zhiyun 
Published: February 2025

IntroductionThe objective of this study was to explore the viewpoints of parents, teachers, and administrators on the factors influencing adolescent physical activity in China.MethodsThe study employed semi-structured interviews with school teachers, school principals, government officers, and parents. Twenty-five participants were recruited from Jiangsu Province, China, and completed the interview.ResultsThe data collected were analysed using grounded theory within the social ecology model framework. The analysis identified 49 concepts across 19 subcategories and five main categories.DiscussionThe resulting theoretical model, constructed using grounded theory, integrated five main categories: individual factors, family environment, school environment, community environment, and policy. This model provides a foundational understanding of the multifaceted influencing factors of adolescent physical activity in China.
Spatiotemporal prevalence of COVID-19 and SARS-CoV-2 variants in Africa
Authors: Gao Li-Ping , Zheng Can-Jun , Tian Ting-Ting , Brima Tia Alie , Abdulai Michael K. , Xiao Kang , Chen Cao , Liang Dong-Lin , Shi Qi , Liu Zhi-Guo , Dong Xiao-Ping 
Published: February 2025

IntroductionThe coronavirus disease 2019 (COVID-19) pandemic has caused significant public health and socioeconomic crises across Africa; however, the prevalent patterns of COVID-19 and the circulating characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in the continent remain insufficiently documented.MethodsIn this study, national data on case numbers, infection incidences, mortality rates, the circulation of SARS-CoV-2 variants, and key health indexes were collected from various official and professional sources between January 2020 and December 2023 were analyzed with SaTScan and geographically weighted regression (GWR).ResultsThe prevalent profiles and circulating features of SARS-CoV-2 across the African continent, including its five regions and all African countries, were analyzed. Four major waves of the epidemic were observed. The first wave was closely associated with the introduction of the early SARS-CoV-2 strain while the subsequent waves were linked to the emergence of specific variants, including variants of concern (VOCs) Alpha, Beta, variants of interest (VOIs) Eta (second wave), VOC Delta (third wave), and VOC Omicron (fourth wave). SaTScan analysis identified four large spatiotemporal clusters that affected various countries. A significant number of countries (50 out of 56) reported their first cases during February 2020 and March 2020, predominantly involving individuals with confirmed cross-continental travel histories, mainly from Europe. In total, 12 distinct SARS-CoV-2 VOCs and VOIs were identified, with the most prevalent being VOCs Omicron, Delta, Beta, Alpha, and VOI Eta. Unlike the dominance of VOC Delta during the third wave and Omicron during the fourth wave, VOC Alpha was relatively rare in the Southern regions but more common in the other four regions. At the same time, Beta predominated in the Southern region and Eta in the Western region during the second wave. Additionally, relatively higher COVID-19 case incidences and mortalities were reported in the Southern and Northern African regions. Spearman rank correlation and geographically weighted regression (GWR) analyses of COVID-19 incidences against health indexes in 52 African countries indicate that countries with higher national health expenditures and better personnel indexes tended to report higher case incidences.DiscussionThis study offers a detailed overview of the COVID-19 pandemic in Africa. Strengthening the capacity of health institutions across African countries is essential for the timely detection of new SARS-CoV-2 variants and, consequently, for preparedness against future COVID-19 pandemics and other potentially infectious disease outbreaks.
Bridging the Gap: Parental Supervision as a Mediator Between Home Environment and Unintentional Injuries in Children Under 3 Years
Authors: Ji Jianlin , Yang Hanlin , Zeng Chengxi , Chen Ouyao , Lu Qunfeng 
Published: February 2025

ObjectivesUnintentional home injuries pose a serious risk to children under 3 years. While parental supervision and home environment are key factors influencing these injuries, few studies have explored the correlation between them. This study aimed to examine the relationship between home environment, parental supervision, and unintentional home injuries, and to investigate whether parental supervision mediates this relationship.MethodsThis study, conducted in Shanghai, China from June to August in 2023, using a convenience sample. Paper questionnaires were distributed to 600 parents of children, assessing unintentional injuries, parent supervision (using parent supervision attributes profile questionnaire), in-home environmental risk scale and demographic variables. A bootstrap test was applied to assess the mediating role of parental supervision.ResultsBoth in-home environment risks and parental supervision were significantly related to unintentional home injuries in children under 3. Moreover, parental supervision was found to partially mediate the relationship between environmental risks and injuries, explaining 14.2% of the total effect.ConclusionChildren under 3 were highly vulnerable to unintentional home injuries. Enhancing parental supervision may reduce the impact of environmental risks on injury occurrence. These findings offer practical guidance for health practitioners, underscoring the value of community-based interventions and tailored educational programs for injury prevention. Future research should explore intervention effectiveness and long-term outcomes.
The Views of Syrian Immigrant Women on Family Planning and Unplanned Pregnancy: A Qualitative Study
Authors: Yakıt Ak Eda , Tandoğan Özden , Aslan Ergül 
Published: February 2025

ObjectivesThis study aimed to determine the views of Syrian immigrant women on family planning and unplanned pregnancies.MethodsThe study was conducted using a phenomenological design, one of the qualitative research methods. The study data were collected using a semi-structured questionnaire, and an “inductive content analysis technique” was used to analyze the data.ResultsThe study identified four main themes. The first theme, “The Meaning of Having Children,” reveals that women view children as the essence of their lives and as a source of security for the future. The second theme, “Opinions on the Number of Children,” highlights that financial concerns and pressure from family and the surrounding environment play a significant role in decisions regarding the number of children. The third theme, “Views on Family Planning,” shows that while women are aware of family planning methods, their use is often limited due to economic, cultural, and religious factors. Lastly, the fourth theme, “Views on Unplanned Pregnancies,” indicates that unplanned pregnancies are commonly regarded as “God’s will,” and abortion is generally deemed inappropriate due to religious beliefs.ConclusionCultural, religious, and economic factors significantly affect women’s access to and use of family planning services.
A Study of Generalized Symmetric Metric Connection on Nearly Kenmotsu Manifolds
Authors: Kumar Rajesh , Chawngthu Laltluangkima , Bahadir Oğuzhan , Khan Meraj Ali 
Published: February 2025

The focus of this research is on investigating a new category of generalized symmetric metric connections within nearly Kenmotsu manifolds. The study delves into recognizing the generalized symmetric connections of type (α, β), which represent broader versions of the semi-symmetric metric connection (α=1, β=0) and the quarter-symmetric metric connection (α=0, β=1).
Sex differences in the prescription of anti-hypertensive medications in primary care patients
Authors: Dal Canto Elisa , Theunisse Sophie L , Bots Michiel L , Rutten Frans , Biermans Marion , Onland-Moret N Charlotte , Spiering Wilko , Kiliç Birsen , Den Ruijter Hester M , Hollander Monika 
Published: February 2025

BackgroundPharmacological prescription guidelines for hypertension lack differentiation between the sexes, despite reported sex differences in prevalence, awareness, pathophysiology and pharmacological response.AimWe aimed to assess prescription patterns of blood pressure lowering medication among women and men in primary care.Design & settingWe analysed data collected in 2018 during routine primary care practice among those pharmacologically treated for elevated blood pressure, and free from cardiovascular comorbidities or diabetes mellitus.MethodWe assessed sex differences in the number of prescribed drugs, defined daily dosage, type of antihypertensive medication, and blood pressure control. We adjusted for differences between sexes in age and other covariates.ResultsThis observational study included 8596 women and 5788 men. Both women and men were prescribed on average 1.8 antihypertensive agents per person. Women compared to men were prescribed a significantly lower defined daily dosage (1.8 vs 2.1,P<0.001), received more often betablockers (35.4% vs 26.3%,P<0.001) and diuretics (53.7% vs 50.5%,P<0.001), while receiving fewer ACE-inhibitors (35.4% vs 46.3%,P<0.001) and calcium channel blockers (28.5% vs 35.6%,P<0.001). No sex differences were found for angiotensin receptor blockers (24.3 vs. 24.4%,P=0.842). Importantly, women had significantly better controlled hypertension than men (50.2% vs 45.5%,P<0.001).ConclusionIn those pharmacologically treated for elevated blood pressure, differences between women and men exist in defined daily dosage, type of antihypertensive medication, and blood pressure control, with women achieving better hypertension control than men with different type of medication and lower dosage.