bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring the α-abundance of Subsolar-metallicity Stars in the Milky Way’s Central Half-parsec: Testing Globular Cluster and Dwarf Galaxy Infall Scenarios
Authors: Bentley Rory O. , Do Tuan , Kerzendorf Wolfgang , Chu Devin S. , Chen Zhuo , Konopacky Quinn , Ghez Andrea 
Published: January 2022

Abstract
While the Milky Way nuclear star cluster (MW NSC) has been studied extensively, how it formed is uncertain. Studies have shown it contains a solar and supersolar metallicity population that may have formed in situ, along with a subsolar-metallicity population that may have formed via mergers of globular clusters and dwarf galaxies. Stellar abundance measurements are critical to differentiate between formation scenarios. We present new measurements of [M/H] and α-element abundances [α/Fe] of two subsolar-metallicity stars in the Galactic center. These observations were taken with the adaptive-optics-assisted high-resolution (R = 24,000) spectrograph NIRSPEC in the K band (1.8–2.6 micron). These are the first α-element abundance measurements of subsolar-metallicity stars in the MW NSC. We measure [M/H] = − 0.59 ± 0.11, [α/Fe] = 0.05 ± 0.15 and [M/H] = − 0.81 ± 0.12, [α/Fe] = 0.15 ± 0.16 for the two stars at the Galactic center; the uncertainties are dominated by systematic uncertainties in the spectral templates. The stars have an [α/Fe] in between the [α/Fe] of globular clusters and dwarf galaxies at similar [M/H] values. Their abundances are very different than the bulk of the stars in the nuclear star cluster. These results indicate that the subsolar-metallicity population in the MW NSC likely originated from infalling dwarf galaxies or globular clusters and are unlikely to have formed in situ.
Trans-Formational Qualities of the Dys-&-Functional – The interplay of the questioning Senses of Real, the quest for a Sense of the Possible and enacting a Sense of the Doable – Non-linear perspectives on spiraling moves
Authors: Kuepers Wendelin 
Published: January 2022

Cet article met en avant des dimensions et qualités critiques, imaginatives et utopiques, ainsi que pragmatiques, dans l’art et l’esthétique ayant une valeur transformatrice pour les études et la pratique organisationnelles et du leadership. Le potentiel de transformation des processus artistiques et esthétiques fait référence à leur capacité à remettre en question le « sens du réel » et à produire un « sens du possible » –tel que décrit par Musil dans son livre « L’homme sans qualités » – complété par un « sens du faisable ». Ceci est faisable grâce à leur capacité critique à remettre en question les sens fermés du « réel » et à offrir des perspectives imaginatives (utopiques) sur ce qui est ou pourrait être possible. En ce sens, les qualités créatives de l’art et de l’esthétique peuvent avoir une fonction critique et libératrice. Celles-ci peuvent être complétées différemment par un sens plus pragmatique de ce qui peut être fait concrètement, et toutes ces fonctions ensemble provoquent des qualités transformationnelles qui sont très pertinentes pour les réalités et les pratiques du leadership et des organisations. Sur la base de ces sens et en relation avec l’art et l’esthétique, la linéarité et les lignes linéaires sont problématisées et le rôle des lignes et des cycles tordus et chasmiques est souligné. Enfin, certaines implications et perspectives sont discutées en conclusion.
L’Église dans le temps de ce monde : imagination, corporéité, altérité
Authors: Brison Sylvain 
Published: January 2022

Parce que l’Église vit en solidarité avec le monde les transformations nécessaires vers le Royaume de Dieu, les crises qui l’affectent questionnent sa nature et révèlent les défis de l’ecclésiologie. L’article tente de dégager les perspectives de penser pour renouveler le discours sur l’Église. La première partie réfléchit la dimension temporelle de la réflexion ecclésiologique afin de déplacer le centre de gravité de la nature de l’Église vers sa finalité. Elle explore également les enjeux de la narrativité pour l’ecclésiologie. La seconde partie examine la relation de l’Église au monde pour proposer une « ecclésiologie politique ». Enfin, l’article ouvre sur les enjeux du « vivre ensemble » l’unité dans la diversité en orientant la réflexion à partir des ressources de l’imagination théologique.
Géographicité de l’être et accaparement des terres agricoles : une problématique de la consubstantialité de la géographie et de l’ontologie
Authors: Sofack Noël 
Published: January 2022

L’accaparement des terres qui est au cœur de l’actualité depuis quelque temps pose fondamentalement un problème anthropologique, philosophique, métaphysique et ontologique. C’est du moins la lecture que l’on peut en faire à partir d’une herméneutique de la pensée d’Augustin Berque et de l’anthropo-cosmologie africaine. En effet, « l’ être de l ’humain est géographique », c’est-à-dire que l’on ne peut pas le penser sans prendre en compte prioritairement sa géographicité. Le propos de cet article consiste à montrer que l’accaparement des terres, qui implique de facto des déplacements forcés des populations autochtones de leur Terre-Mère, conduit à une sorte de dys-localisation, c’est-à-dire à une rupture du lien consubstantiel entre géographie et ontologie, mettant ainsi en cause la géographicité de l’être.
Être maître selon Ortega y Gasset
Authors: Bonilla Javier Zamora 
Published: January 2022

Le philosophe espagnol José Ortega y Gasset a écrit de nombreux textes à propos de la pédagogie, qui dès sa jeunesse fut une préoccupation majeure. Nous analysons ici ses idées pédagogiques à partir de concepts tels que « pédagogie du paysage », « pédagogie de l’allusion », « pédagogie de la contamination », « vocation » et « mission ». L’influence de la philosophie krausiste de Francisco Giner de los Ríos sur la pensée ortéguienne a été notable, comme nous pourrons le voir. Ils entretinrent une relation étroite et, surtout, ils désiraient avec la même ardeur moderniser la société espagnole. Ortega y Gasset transposa ses idées pédagogiques à sa propre expérience de professeur d’université. Beaucoup de ses disciples en ont témoigné, comme nous le rapportons ici.
Enhancing pharmaceutical potential and oral bioavailability of Allium cepa nanosuspension in male albino rats using response surface methodology
Authors: Zafar Fatiqa , Jahan Nazish , Ali Shaukat , Jamil Saba , Hussain Riaz , Aslam Saba 
Published: January 2022

Objective:
To enhance the pharmaceutical potential and oral bioavailability of quercetin contents of Allium cepa peel extract by novel nanosuspension technology.

Methods:
Nanoprecipitation approach was successfully used for the formulation of nanosuspension. To obtain pharmaceutical-grade nanosuspension with minimum particle size and polydispersity index, sodium lauryl sulphate was selected as a stabilizer. Important formulation parameters were statistically optimized by the response surface methodology approach. The optimized nanosuspension was subjected to stability and in vitro dissolution testing and characterized by scanning electron microscopy, atomic force microscopy, Fourier transform infrared spectroscopy, and zeta sizer. To evaluate the preeminence of nanosuspension over coarse suspension, comparative bioavailability studies were carried out in male albino rats. The pharmaceutical potential of developed nanosuspension was evaluated by antioxidant, antimicrobial, and toxicity studies.

Results:
The optimized nanosuspension showed an average particle size of 275.5 nm with a polydispersity index and zeta potential value of 0.415 and -48.8 mV, respectively. Atomic force microscopy revealed that the average particle size of nanosuspension was below 100 nm. The formulated nanosuspension showed better stability under refrigerated conditions. Nanosuspension showed an improved dissolution rate and a 2.14-fold greater plasma concentration of quercetin than coarse suspension. Moreover, the formulated nanosuspension exhibited enhanced antioxidant and antimicrobial potential and was non-toxic.

Conclusions:
Optimization of nanosuspension effectively improves the pharmaceutical potential and oral bioavailability of Allium cepa extract.
Protein extract of kenaf seed exhibits anticoagulant, antiplatelet and antioxidant activities
Authors: Hanumegowda Sujatha M. , Srinivasa Chandramma , Shivaiah Ashwini , Venkatappa Manjula M. , Hanumanthappa Ramesha , Rangappa Rajesh , Laxmaiah Ramesh K. , Gonchigar Sathisha J. , Sannaningaiah Devaraja 
Published: January 2022

Objective:
To explore the anticoagulant, antiplatelet and antioxidant activities of protein extract of kenaf seed (PEKS).

Methods:
Sodium dodecyl sulphate polyacrylamide gel electrophoresis and reverse-phase high-performance liquid chromatography techniques were employed for protein characterization. Antioxidant activity of PEKS was assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The protective effect of PEKS on sodium nitrite (NaNO2) induced oxidative stress was evaluated using the in vitro red blood cell model, while the effect of PEKS on diclofenac-induced oxidative stress was examined in vivo in rats. Platelet-rich plasma and platelet-poor plasma were used for anticoagulant and antiplatelet activities of PEKS.

Results:
PEKS revealed similar protein bands on SDS-PAGE under reduced and non-reduced conditions. Several acidic proteins were present in native PAGE. PEKS showed antioxidant properties by scavenging DPPH with an IC50 of 24.58 μg. PEKS exhibited a protective effect on NaNO2 induced oxidative stress in red blood cells by restoring the activity of stress markers. In addition, PEKS alleviated diclofenac-induced tissue damage of the liver, kidney, and small intestine. PEKS showed an anticoagulant effect in both in vivo and in vitro experiments by enhancing normal clotting time. PEKS did not affect prothrombin time but increase activated partial thromboplastin time. Furthermore, PEKS inhibited adenosine diphosphate and epinephrine-induced platelet aggregation.

Conclusions:
PEKS protects tissues from oxidative stress and exhibits antithrombotic activity.
Barrientosiimonas humi ethyl acetate extract exerts cytotoxicity against MCF-7 and MDA-MB-231 cells via induction of apoptosis and cell cycle arrest
Authors: Yeoh Chiann Ying , Rosandy Andi Rifki , Khalid Rozida Mohd , Cheah Yoke Kqueen 
Published: January 2022

Objective:
To elucidate the cytotoxic effect of the secondary metabolites of Barrientosiimonas humi (B. humi) on MCF-7 and MDA-MB-231 human breast cancer cells and its underlying mechanisms of action.

Methods:
The extract was obtained from the fermentation of B. humi and fractionation of the crude extract was conducted via column chromatography. Cytotoxicity of the B. humi extract was determined by using MTT assay and real-time cellular analysis. Morphological changes, cell cycle profiles, mode of cell death, and caspase expressions of control and treated breast cancer cells were determined.

Results:
The ethyl acetate extract isolated from B. humi was cytotoxic against MCF-7 and MDA-MB-231 cell lines. One of the dichloromethane (DCM) fractions, designated as DCM-F2, exhibited the strongest activity among all the fractions and thereby was selected for further studies. DCM-F2 had selective cytotoxicity on target cells by inducing apoptosis, particularly in the early stage, and cell cycle arrest. Treated cells caused inhibition of cell cycle progression at 72 h leading to a significant increase (P < 0.05) in the G0/G1 population. DCM-F2 treated MDA-MB-231 cells showed caspase-dependent apoptosis, whereas DCM-F2 treated MCF-7 cells showed a caspase-independent apoptosis pathway. Five compounds were successfully isolated from B. humi. Cyclo (Pro-Tyr) was the most cytotoxic and selective compound against MCF-7 cells.

Conclusions:

B. humi ethyl acetate extract exhibits significant cytotoxicity against MCF-7 and MDA-MB-231 cells via induction of apoptosis and cell cycle arrest.
Taurine in semen extender modulates post-thaw semen quality, sperm kinematics and oxidative stress status in mithun (Bos frontalis) spermatozoa
Authors: Ponraj Perumal , Khate Kobu , Vupru Kezhavituo 
Published: January 2022

Objective:
To assess the effect of taurine on post-thaw semen quality parameters, sperm kinematics, antioxidant and oxidative stress profiles and sperm cholesterol efflux in mithun (Bos frontalis).

Methods:
A total of 50 ejaculates (n=25 samples) were selected based on biophysical parameters. Each sample was split into four equal aliquots after dilution with the Tris-citrate-glycerol extender. Group I, II, III and IV contained 0 mM (the control), 25 mM, 50 mM and 100 mM of taurine, respectively. Frozen-thawed samples were analysed for motility parameters (progressive forward and in bovine cervical mucus penetration test), kinetic and velocity parameters by computer-assisted sperm analyzer, viability, sperm and nuclear abnormalities, acrosome integrity, plasma membrane and nuclear integrities, sperm enzymatic leakage and biochemical (sperm cholesterol and oxidative stress) profiles.

Results:
The extender containing 50 mM taurine led to a significant enhancement in viability, acrosomal integrity, plasma membrane integrity, motility (progressive and in cervical mucus), and sperm cholesterol content and notably reduced sperm morphological and nuclear abnormalities, and leakage of intracellular enzymes compared to other taurine treated and untreated control groups (P<0.05). Moreover, in addition to significant improvement in kinetic and velocity profiles, 50 mM taurine protected the integrity of acrosome and biochemical membranes than in the untreated control and other taurine treated groups. Inclusion of 50 mM taurine held a clear advantage over the control or 25 mM or 100 mM taurine in cryopreservation of mithun semen.

Conclusions:
Taurine (50 mM) supplementation in semen extender can be effectively utilized to reduce oxidative stress and improve post-thaw semen quality in mithun.
Correlation between macular perfusion and ganglion-cell complex thickness in primary open-angle glaucoma patients using optical coherence tomography angiography
Authors: Hassan Lameece M. , Abdelrahman Ahmed M. , Habib Mina M. , Kotb Mohamed S. 
Published: January 2022

Purpose
The aim of this study was to correlate the macular perfusion and ganglion-cell complex (GCC) thickness in patients with primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCTA).

Patients and methods
This is a cross-sectional observational study that included 51 eyes of 51 patients with POAG. The vascular density (VD) in the superficial vascular complex and deep vascular complex (SVC and DVC) was assessed by OCTA and the GCC thickness was assessed by spectral-domain OCT. Patients were divided into three groups according to severity by visual field mean deviation into mild (less than −6.0 dB), moderate (between −6.0 and −12.0 dB), and severe (more than −12.0 dB).

Results
The mean VD measurements in the SVC were 46.0±5.8, 45.8±4.4, and 36.0±6.6 in the ‘mild,’ ‘moderate,’ and ‘severe’ groups, respectively, while in the DVC, the mean VD measurements were 49.8±8.0, 47.0±7.4, and 40.4±9.4, respectively. The differences in the VD between the three groups were more significant in the SVC (P<0.001) than in the DVC (P=0.004). The correlation between the GCC thickness and the VD was statistically significant in the SVC only in the whole image and in the perifoveal area (P<0.001).

Conclusion
In POAG patients, changes in VD in the macular area measured with OCTA can be correlated with GCC changes and visual-field changes and can be used as a diagnostic tool. POAG preferentially affects the SVC rather than the DVC.
Factors Associated with Nonadherence to Antiretroviral Therapy among Children with HIV/AIDS in Ahmadu Bello University Teaching Hospital, Zaria, Nigeria
Authors: Musa Abdullahi , Sabitu Kabiru , Suleiman Idris Hadejia , Usman Aishat Bukola , Abubakar Yakubu 
Published: January 2022

Background:
The advent of antiretroviral (ARV) treatment in combined therapy has transformed HIV/AIDS into a chronic treatable condition and significantly improved the prognosis and quality of life of patients with HIV/AIDS. However, to achieve this, patients have to maintain strict adherence which has been shown to be affected by several factors. This study, therefore, aimed to estimate and identify factors associated with adherence to ARV drugs among children attending Paediatric ARV Clinic at Ahmadu Bello University Teaching Hospital, Zaria.

Subjects and Methods:
Sociodemographic and clinical information of the children and their caregivers was collected using a semi-structured questionnaire. Bivariate and multivariate analyses were done to examine the odds of adherence and nonadherence to ARV therapy with respect to the various factors. P = 0.05 was considered statistically significant.

Results:
A total of 167 children and their caregivers were studied. The children were aged between 2 and 17 years with a mean age of 9.1 ± 3.4 years, while the caregivers were aged between 20 and 70 years with a mean age of 37.6 ± 10.7 years. The estimated adherence in the past 30 days was found to be 76.6%. Caregivers' forgetfulness and traveling were reported as the major reasons for missing medications. Caregivers' age <35 years was significantly associated with poor adherence (odds ratio = 2.35 [95% confidence interval: 1.09–5.06]).

Conclusion:
Caregiver factors were the main factors associated with poor adherence in children with HIV. We recommend regular adherence counseling at every visit with emphasis on the use of reminder methods to improve adherence.
Awareness of Dental Trauma Management among School Teachers in Dammam, Saudi Arabia
Authors: Al-Khalifa Khalifa S. , AlYousef Yousef 
Published: January 2022

Background:
Children and young adolescents commonly suffer traumatic dental injuries. Teachers are frequently first responders and responsible for the initial management of the injury; the prognosis of a traumatized tooth is dependent on the initial management.

Aim:
To evaluate intermediate school teachers’ level of knowledge and attitudes toward dental trauma.

Materials and Methods:
This is a questionnaire-based cross-sectional study where all teachers from eight non-probability selected intermediate schools in Dammam, Saudi Arabia, were invited for participation. The questionnaire elicited data regarding demographics, teaching experience, knowledge and attitudes regarding dental trauma and its management.

Results:
A total 398 of 433 invited teachers responded (92%). The male-to-female ratio was 2:1. Only 30% of the respondents had previously participated in first aid training; only 11% specifically also focused on dental traumas. Health-care providers represented the main source of knowledge regarding dental trauma. Bivariate analysis revealed that in terms of attitudes toward dental trauma, urgency of care for luxation injuries was significantly associated with teaching experience (P = 0.042), while the urgency of care for avulsed teeth was significantly associated with dental trauma experience (P = 0.007). The only significant association between teaching experience and knowledge about management of avulsed teeth was regarding which tooth should be replanted (P = 0.041).

Conclusions:
School teachers in Dammam, Saudi Arabia, lack proper knowledge in dental emergency management. Educational training programs are needed to ensure that teaching staff have adequate knowledge to effectively manage dental traumas.
Salivary Lactoferrin Levels, Disease Severity and Correlates in Patients with Chronic Periodontitis Presenting to a Tertiary Health Facility in Nigeria.
Authors: ORHUE Vera Eigbibhalu , EHIZELE Adebola Oluyemisi , AKHIONBARE Osagie , OJEHANON Patrick 
Published: January 2022

Objective: This study compared the concentration of salivary lactoferrin in patients with and without chronic periodontitis and investigated correlations with clinical variables of the disease.
Methods: The study included 102 participants (51 cases and 51 controls) who presented at the Periodontology Clinic of University of Benin Teaching Hospital and met the selection criteria of ‘4mm and above’ periodontal probing depths (PPD) and positive bleeding on probing (BOP) using community periodontal index (CPI) probe. Healthy participants (controls) were patients that had PPD less than or equal to 3mm, absence of BOP and simplified oral hygiene index (OHI-S) not more than 1.2. Baseline OHI-S and CPI scores were recorded. Saliva samples were collected and analyzed using enzyme-linked immunosorbent assay. All data were analyzed with the Statistical Package for Social Sciences (SPSS) version 22.0.
Results: There was a statistically significant difference between the mean (SD) lactoferrin concentration of control participants 5.27(0.59) mg/l and case participants 6.74(0.61) mg/l (p<0.001). Participants with probing pocket depths (PPD) of 6mm or more had a significantly higher mean concentration [6.85(0.06) mg/l] than that of those with PPD 4-5mm [6.71(0.67) mg/l] (p < 0.001) Lactoferrin levels were highest in participants with ‘poor’ oral hygiene [6.85(0.60) mg/l] and lowest in those with ‘good’ oral hygiene [6.65(0.83) mg/l].
Conclusion: Salivary lactoferrin levels were higher among participants with chronic periodontitis than those without chronic periodontitis and correlates positively with the main clinical characteristics of the disease
Analisis Pengaruh Kepemimpinan, Motivasi dan Disiplin Kerja Terhadap Kinerja Karyawan Toko Raysa Pemadam Joglo
Authors: Setiawan Ade 
Published: January 2022

Kendala yang sering terjadi adalah ketika jadwal pengiriman mengalami keterlambatan, dalam keadaan inilah perlu disiplin kerja yang baik, agar bisa di tindak lanjuti sesegera mungkin sehingga tidak menimbulkan kekecewaan dari konsumen. Penelitian ini bertujuan untuk mendeskripsikan masalah yang ada pada Toko Raysa Pemadam yang dimana perkembangan sektor bisnis kebutuhan dasar rumah tangga (sembako) peluang bagi perusahaan kecil untuk sub pekerjaan sektoral. Memanfaatkan peluang dalam meraih konsumen, menciptakan persaingan antara perusahaan-perusahaan jasa perbaikan serupa. Hal ini juga membuat setiap perusahaan harus menginovasi strategi pemasaran yang kreatif dalam menjual barang yang ditawarkan kepada target sasaran. Penelitian ini bertujuan untuk mengetahui pengaruh kepemimpinan, motivasi dan disiplin kerja terhadap kinerja karyawan, untuk kepemimpinan secara parsial kinerja karyawan. Jenis penelitian yang digunakan dalam penulisan ini merupakan penelitian deskriptif, dengan menggunakan pendekatan kualitatif. Hasil yang diperoleh yakni Toko Raysa Pemadam Joglo merupakan Usaha kecil dibidang kehutuhan rumah tangga (Sembako) di Joglo Jakarta Barat. Hasil yang diperoleh ialah Usaha kecil dan menengah ini (UMKM) melaksanakan kepemimpinan yang baik dengan karyawan, motivasi karyawan dengan bentuk reward kepada karyawannya dan juga tingkat displin yang baik yang mana sangat minim complain dari para konsumen
MANAJEMEN PELAKSANAAN SUPERVISI AKADEMIK OLEH PENGAWAS MADRASAH ALIYAH DI BARAT SELATAN ACEH
Authors: Hanifuddin Jamin  
Published: January 2022

Penelitian ini dilakukan di Madrasah Aliyah dan Pengawas Tingkat Aliyah di Barat Selatan Aceh bertujuan untuk mengetahui Bagaimana Manajemen Perencanaan Pelaksanaan Supervisi Akademik yang dilakukan oleh Pengawas Madrasah, Pendekatan yang digunakan dalam penelitian ini yaitu pendekatan kualitatif, teknik pengumpulan data melalui observasi, wawancara dan studi dokumentasi, subjek penelitian adalah Pengawas Madrasah, Kepala Madrasah dan guru. Penelitian ini memberikan kesimpulan bahwa, program supervisi Akademik yang disusun oleh pengawas madrasah adalah meliputi program semester dan program tahunan yang meliputi pembinaan kinerja guru dalam kelompok dan pembinaan individual guru. Pelaksanaan supervisi Akademik dalam rangka peningkatan kompetensi professional guru dilakukan melalui observasi kelas, pertemuan individu, diskusi kelompok dan demontrasi mengajar.