bluuebunny/crossref_metadata_2025_split huggingface dataset:
The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles inDrosophila
Authors: Frasch Manfred , Ismat Afshan , Reim Ingolf , Raufer Jasmin 
Published: November 2022

SummaryThe development of the visceral musculature of theDrosophilamidgut encompasses a closely coordinated sequence of migration events of cells from the trunk and caudal visceral mesoderm, respectively, that underlies the formation of the stereotypic orthogonal pattern of circular and longitudinal midgut muscles. Our current study focuses on the last step of migration and morphogenesis of the longitudinal visceral muscle precursors derived from the caudal mesoderm. We show that these multinucleated muscle precursors utilize dynamic filopodial extensions to migrate in dorsal and ventral directions over the forming midgut tube. The establishment of maximal dorsoventral distances from one another and subsequent alignment with their anteroposterior neighbors leads to the equidistant coverage of the midgut with longitudinal muscle fibers. We identify Teyrha-Meyhra (Tey), a tissue-specific nuclear factor related to the RNF220 domain protein family, as a crucial regulator of this process of muscle migration and morphogenesis that is further required for proper differentiation of the longitudinal visceral muscles. In addition, Tey is expressed in a single type of somatic muscle founder cell in each hemisegment. Tey regulates the migration of this founder cell and is required for the proper pathfinding of its developing myotube to specific myotendinous attachment sites.
A single extracellular loop of FoxA controls ligand specificity, uptake, and signaling inPseudomonas aeruginosa
Authors: Chan Derek C. K. , Josts Inokentijs , Koteva Kalinka , Wright Gerard D. , Tidow Henning , Burrows Lori L. 
Published: November 2022

AbstractThe outer membrane of Gram-negative bacteria prevents many antibiotics from reaching intracellular targets. However, some antimicrobials can take advantage of iron import transporters to cross this barrier. We showed previously that the thiopeptide antibiotic, thiocillin, exploits the nocardamine (ferrioxamine E) xenosiderophore transporter, FoxA, of the opportunistic pathogenPseudomonas aeruginosafor uptake. Here we show that FoxA also transports the xenosiderophore bisucaberin and describe at 2.5 Å resolution the first crystal structure of bisucaberin bound to FoxA. Bisucaberin is distinct from other siderophores because it forms a 3:2 rather than 1:1 siderophore-iron complex. Mutations in a single extracellular loop of FoxA differentially affected nocardamine, thiocillin, and bisucaberin binding, uptake, and signal transduction. These results show that in addition to modulating ligand binding, the extracellular loops of siderophore transporters are of fundamental importance for controlling ligand uptake and its regulatory consequences, which has implications for the development of siderophore-antibiotic conjugates to treat difficult infections.
Sensory Reweighting: A Common Mechanism for Subjective Visual Vertical and Cybersickness Susceptibility
Authors: Chung William , Barnett-Cowan Michael 
Published: November 2022

AbstractThe malaise symptoms of cybersickness are thought to be related to the sensory conflict present in the exposure to virtual reality (VR) content. When there is a sensory mismatch in the process of sensory perception, the perceptual estimate has been shown to change based on a reweighting mechanism between the relative contributions of the individual sensory signals involved. In this study, the reweighting of vestibular and body signals was assessed before and after exposure to different typical VR experiences and sickness severity was measured to investigate the relationship between susceptibility to cybersickness and sensory reweighting. Participants reported whether a visually presented line was rotated clockwise or counterclockwise from vertical while laying on their side in a subjective visual vertical (SVV) task. Task performance was recorded prior to VR exposure and after a low and high intensity VR game. The results show that the SVV was significantly shifted away from the body representation of upright and towards the vestibular signal after exposure to the high intensity VR game. Cybersickness measured using the fast motion sickness (FMS) scale found that sickness severity ratings were higher in the high intensity compared to the low intensity experience. The change in SVV from baseline after each VR exposure modelled using a simple 3-parameter gaussian regression fit was found to explain 49.5% of the variance in the FMS ratings. These results highlight the aftereffects of VR for sensory perception and suggests a potential relationship between the susceptibility to cybersickness and sensory reweighting.
Thermoconforming rays of the star-nosed mole
Authors: Tattersall Glenn J. , Campbell Kevin L. 
Published: November 2022

AbstractThe star-nosed mole (Condylura cristata) is well known for its unique star-like rostrum (‘star’) which is formed by 22 nasal appendages highly specialised for tactile sensation. As a northerly distributed insectivorous mammal occupying both aquatic and terrestrial habitats, this sensory appendage is regularly exposed to cold water and thermally conductive soil, leading us to ask whether the surface temperature, a proxy for blood flow to the star, conforms to the local ambient temperature to conserve body heat. Alternatively, given the high functioning and sensory nature of the star, we posited it was possible that the rays may be kept continually warm when foraging, with augmented peripheral blood flow serving the metabolic needs of this tactile sensory organ. To test these ideas, we remotely monitored the surface temperatures of the star and other uninsulated appendages in response to changes in local water or ground temperature in captive, wild-caught star-nosed moles. While the tail responded to increasing heat load through vasodilation, the surface temperature of the star consistently thermoconformed, varying passively in surface temperature, suggesting little evidence for thermoregulatory vasomotion. This thermoconforming response may have evolved as a compensatory response related to the high costs of heat dissipation to water or soil in this actively foraging insectivore.Summary Statement (for JEB Submission)The highly mechanosensitive nasal rays of the star-nosed mole conform closely with ambient temperature thereby minimizing heat loss without apparent changes in sensory performance.
Endocrine disruption of early uterine differentiation causes adenocarcinoma mediated by Wnt/β-catenin- and PI3K/AKT signaling
Authors: Padilla-Banks Elizabeth , Jefferson Wendy N. , Papas Brian N. , Suen Alisa A. , Xu Xin , Carreon Diana V. , Willson Cynthia J. , Quist Erin M. , Williams Carmen J. 
Published: November 2022

AbstractDevelopmental exposure to non-mutagenic environmental factors can contribute to cancer risk, but the underlying mechanisms are not understood. We used a mouse model of endometrial adenocarcinoma that results from brief developmental exposure to an estrogenic chemical, diethylstilbestrol (DES), to determine causative factors. Single cell RNA sequencing and spatial transcriptomics of adult uteri revealed new markers of uterine epithelial stem cells, identified luminal and glandular progenitor cells, and defined a glandular epithelial differentiation trajectory. Neonatal DES exposure disrupted uterine epithelial differentiation, resulting in widespread activation of Wnt signaling and a failure to generate epithelial stem cells or distinguishable glandular and luminal epithelial cells. The endometrial stromal cells activated inflammatory signals and oxidative stress. Together, these changes activated PI3K/AKT signaling to drive malignant transformation. These findings explain how human cancers, which are often associated with abnormal activation of PI3K/AKT signaling, could result from exposure to environmental insults during development.HighlightsSingle cell analysis of adult mouse uteri reveals epithelial stem cell markers and gland development trajectoryDevelopmental DES exposure causes widespread activation of Wnt signaling and failure of epithelial cell differentiationUterine adenocarcinoma results from combined Wnt/β-catenin activation, stromal inflammation, and induction of PI3K/AKT signalingOLFM4 is a marker of developmental DES-induced uterine adenocarcinoma
Barriers and enablers to blood culture sampling: a systematic review and theoretical domains framework survey in Indonesia, Thailand and Vietnam
Authors: Suntornsut Pornpan , Asadinia Koe Stella , Limato Ralalicia , Tamara Alice , Rotty Linda W.A. , Bramanti Rendra , Nusantara Dwi U. , Nelwan Erni J. , Khusuwan Suwimon , Suphamongkholchaikul Watthanapong , Chamnan Parinya , Piyaphanee Watcharapong , Huong Vu Thi Lan , Yen Nguyen Hai , Hong Khanh Nguyen , Thach Pham Ngoc , Quang Le Minh , Vinh Vu Hai , Duc Chau Minh , Em Vo Thi Hoang Dung , Harriss Elinor , Doorn H Rogier van , Hamers Raph L. , Lorencatto Fabiana , Atkins Lou , Limmathurotsakul Direk 
Published: November 2022

AbstractBackgroundBlood culture (BC) sampling is recommended for all suspected sepsis patients prior to antibiotic administration. Here, we aimed to identify barriers and enablers to BC sampling in three Southeast Asian countries.MethodsWe conducted a systematic review of studies evaluating barriers/enablers to BC sampling from 1900 to 2020 globally (PROSPERO, CRD42020206557). Using the findings of the systematic review, we developed and conducted a Theoretical Domains Framework (TDF)-based survey with a case scenario question among doctors and final-year medical students in Indonesia, Thailand and Vietnam.FindingsIn the systematic review, we identified 6,175 unique records from the databases, of which 25 met the eligibility criteria. Studies were conducted in 37 high-income countries (HICs) and 41 low-and middle-income countries (LMICs). Of 14 TDF domains, three and seven were not assessed in HICs and LMICs by the studies included in the systematic review, respectively. 1,070 medical doctors and 238 final-year medical students completed the survey. The proportion of respondents who would definitely take BC in the case scenario was 89.8% for Thai, 50.5% for Vietnamese and 31.3% for Indonesians (p<0.001). Eight TDF domains were considered key in influencing BC sampling, including ‘no awareness of guideline [TDF-knowledge]’, ‘low priority of BC [TDF-goals]’, ‘no intention to follow guidelines [TDF-intention]’, ‘level of doctors who can order or initiate an order for BC [TDF-social professional role and identity]’, ‘no norms of BC sampling [TDF-social influence]’, ‘perceived cost-effectiveness of BC [TDF-environmental context and resources]’, ‘regulation on cost reimbursement [TDF-behavioural regulation]’ and ‘consequences that discourage BC sampling [TDF-reinforcement].’ However, there was substantial heterogeneity between the countries across most domains.ConclusionsEvidence on barriers and enablers to BC sampling is limited globally. We identified individual, socio-cultural and environmental barriers/enablers to BC sampling across different countries, which represent potential targets for interventions. Context-specific multifaceted interventions at both hospital and policy levels are required to improve diagnostic stewardship practices.FundingWellcome Trust, UK (220557/Z/20/Z).
Methodological insights: interview quotations in accounting research
Authors: Brennan Niamh M. 
Published: November 2022

PurposeUnlike quantitative studies, interview data generally cannot be validated; yet, they are typically the only evidence of the research. This study develops protocols for using verbatim interview quotations in research and for assessing the quality of interview quotations.Design/methodology/approachThis research reviews 20 empirical papers using in-depth interviews containing 600 interview quotations to examine authors' approaches to verbatim interviewee quotations. The research analyses the sample papers for interview transcript handling, selection of quotations, the number and length of interview quotations, how they are placed and presented, the proportion of interviewee voices reproduced in quotations and the disclosure of protocols for translating and editing quotations. This paper includes illustrative interview quotations as exemplars of best practice.FindingsGiven the modest discussion of the principles influencing the reproduction of quotations in research, this study develops a framework for evaluating prior research. Researchers use a wide variety of practices to reproduce interview quotations in accounting research. The issues derived from this review, and their application to interview-based papers, frame an argument for a general set of quality criteria and protocols rather than rigid rules for assessing qualitative work. These criteria can serve as anchor points for qualitative evaluation.Originality/valueThere is little guidance on the use of interview quotations in qualitative research which this study bridges.
Similarities and differences between absorptive capacity and appropriability: a bibliometric perspective
Authors: Cuéllar Sergio David , Fernandez-Bajón Maria Teresa , Moya-Anegón Felix de 
Published: November 2022

PurposeThis study aimed to examine the similarities and differences between the ability to analyze the environment and exploit new knowledge (absorptive capacity) and the skills to generate value from innovation (appropriation). These fields have similar origins and are sometimes confused by practitioners and academics.Design/methodology/approachA review was conducted based on a full-text analysis of 681 and 431 papers on appropriation and absorptive capacity, respectively, from Scopus, Science Direct and Lens, using methodologies such as text mining, backward citation analysis, modularity clustering and latent Dirichlet allocation analysis.FindingsIn business disciplines, the fields are considered different; however, in other disciplines, it was found that some authors defined them quite similarly. The citation analysis results showed that appropriation was more relevant to absorptive capacity, or vice versa. From the dimension perspective, it was found that although appropriation was considered a relevant element for absorptive capacity, the last models did not include it. Finally, it was found that studies on both topics identified the importance of appropriation and absorptive capacity for innovation performance, knowledge management and technology transfer.Originality/valueThis is one of the first studies to examine in-depth the relationship between appropriation and absorptive capacity, bridging a gap in both fields.
Investigating the influence of perceived organizational justice on counterproductive work behaviours: mediating role of negative emotions
Authors: Aisha Rabail , Channa Nisar Ahmed , Mirani Manzoor Ali , Qureshi Naveed Akhtar 
Published: November 2022

PurposeUsing the theoretical lens of appraisal theory, this research aims to investigate the interrelationship between employees' organizational justice perceptions and counterproductive work behaviours (CWBs) through the mediation of negative emotions.Design/methodology/approachTo this end, a sample comprised of 207 banking sector employees of Pakistan was utilized to test hypothesized relationships. The collected data were analyzed through the partial least structural equation modelling technique.FindingsResults show that counterwork behaviours are influenced by distributive and procedural justice perceptions. The mediating effects of negative emotions were also statistically significant between procedural, interpersonal and informational justice perceptions and counterwork behaviours. No gender differences were found between distributive, interpersonal and informational justice perceptions and counterwork behaviours. However, the authors found that procedural justice perceptions of female employees are strongly related to CWBs as compared to male employees.Originality/valueThis research contributes to the existing organizational behaviour literature by empirically testing the hypothesized relationships using the theoretical lens of appraisal theory with advanced quantitative data analysis techniques.
The fit between GLOBE cultural dimensions, budget transparency and performance management across emerging economies
Authors: Zarei Hamid , Yazdifar Hassan , Nasseri Ahmad , Dahmarde Ghaleno Mohsen 
Published: November 2022

PurposeThere is a dearth of research that investigates the impact of national culture on budgeting and management indexes in the public sector across developing countries. Limited studies in accounting and management have explained the role of national culture in shaping organisational and individual values. It is posited that national cultural variables impact budget transparency and performance management. This study contributes to the literature by examining these relations in 16 developing countries.Design/methodology/approachAdopting an unbalanced timing framework, the current paper seeks to fulfill this gap and applies four cultural dimensions from the GLOBE study (House et al., 2004) as explanatory variables to investigate whether national culture is associated with budget transparency and performance management or not, particularly in the context of developing countries. The paper uses budget transparency as the first dependent variable, based on the OECD database from Qi and Mensah (2011), along with performance management as the second dependent variable, from the BTI Project (2016), according to the leadership's political performance management.FindingsGenerally, the empirical findings reveal a minimal relation among GLOBE cultural variables with budget transparency and performance management. Particularly, the empirical findings indicate that only performance orientation has a significant relation with budget transparency and performance management.Research limitations/implicationsThe findings of this paper suggest that any plan to improve a nation's budget transparency should consider the links between budgeting, performance management and the culture of those that run them.Originality/valueThe formal adoption of new methods by performance management may not be enough without accompanying efforts to transform performance orientation as an index of national culture.
Parasitic plants indirectly regulate decomposition of soil organic matter
Authors: Yuan Yongge , Lin Xinru , Chen Gelv , van Kleunen Mark , Li Junmin 
Published: November 2022

Abstract

Parasitic plants have been shown to affect soil‐organic‐matter (SOM) decomposition, but the mechanism is unknown. As arbuscular mycorrhizal fungi (AMF) can affect decomposition and compete with parasitic plants for carbon, we hypothesized that parasitic plants can indirectly regulate SOM decomposition by suppressing the effects of AMF on decomposition.

To test this hypothesis, we conducted two container experiments in which the herbaceous plant Bidens pilosa was inoculated with the AMF Rhizophagus intraradices or not, and Cuscuta australis or not. In one experiment, we provided SOM within hyphae‐in‐growth bags as 13C‐/15 N‐labelled maize leaves and in the other experiment as phytate‐P. We assessed growth and nutrient uptake of B. pilosa, growth of C. australis, the SOM remaining in the hyphae‐in‐growth bags, and the bacterial communities.

Parasitization increased the 13C and decreased the organic P remaining in the bags, but only in the presence of the extraradical AMF hyphae. AMF decreased the 13C and increased the organic P remaining in the absence of the parasite, but not in the presence of the parasite.

Our results demonstrate that parasitic plants can regulate the decomposition of organic materials indirectly by suppressing the effect of the extraradical AMF hyphae on decomposition. In other words, parasitic plants can regulate SOM decomposition indirectly via a multitrophic cascading effect. Our study helps to unravel the mechanisms of a sophisticated hidden ecological process, and is an important step forward in elucidating the roles of parasitic plants in soil nutrient cycling.

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Biological Flora of Britain and Ireland:Viscum album
Authors: Thomas Peter A. , Dering Monika , Giertych Marian J. , Iszkuło Grzegorz , Tomaszewski Dominik , Briggs Jonathan 
Published: November 2022

AbstractThis account presents information on all aspects of the biology ofViscum albumL. (Mistletoe) that are relevant to understanding its ecological characteristics and behaviour. The main topics are presented within the standard framework of theBiological Flora of Britain and Ireland: distribution, habitat, communities, responses to biotic factors, responses to environment, structure and physiology, phenology, floral and seed characters, herbivores and disease, history, and conservation.Viscum albumis a widespread obligate hemiparasite on a wide range of angiosperm and gymnosperm trees. Once thought to take just water and nutrients from its host via a haustorium, it is now suggested to also take carbon. Heavy infestations can reduce host vitality through prolific water use and carbon removal.Flowers are highly reduced but are primarily pollinated by flies, ants and bees. Seeds are dispersed by birds. Removal of the epicarp is necessary for successful seedling establishment, and seeds have a sticky viscin coat, adhering it to the host bark. Vegetative spread also happens under the bark of its host resulting in densities of >700 Mistletoe plants per host.Viscum albumis a lowland species, most frequent in open human‐made habitats extending into woodlands in Europe. It has been widely planted for folklore use centred around Christmas. Despite conservation concerns following removal of Mistletoe‐laden old orchards, the species is thriving and needs control in some areas. Viscotoxins and lectins in leaves and shoots have been widely used in herbal medicine and now potentially in complementary cancer therapy.