bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testing inter-observer error under a collaborative research framework for studying lithic shape variability
Authors: Timbrell Lucy , Scott Christopher , Habte Behailu , Tefera Yosef , Monod Hélène , Qazzih Mouna , Marais Benjamin , Black Wendy , Maroma Christine , Ndiema Emmanuel , Henderson Struan , Elmes Katherine , Plomp Kimberly , Grove Matt 
Published: June 2022

Abstract
Evaluating error that arises through the aggregation of data recorded by multiple observers is a key consideration in many metric and geometric morphometric analyses of stone tool shape. One of the most common approaches involves the convergence of observers for repeat trails on the same set of artefacts, however this is logistically and financially challenging when collaborating internationally and/or at a large-scale. We present and evaluate a unique alternative for testing inter-observer error, involving the development of 3D printed copies of a lithic reference collection for distribution among observers. With the aim of reducing error, clear protocols were developed for photographing and measuring the replicas, and inter-observer variability was assessed on the replicas in comparison with a corresponding data set recorded by a single observer. Our results demonstrate that, when the photography procedure is standardized and dimensions are clearly defined, the resulting metric and geometric morphometric data are minimally affected by inter-observer error, supporting this method as an effective solution for assessing error under collaborative research frameworks. Collaboration is becoming increasingly important within archaeological and anthropological sciences in order to increase the accessibility of samples, encourage dual-project development between foreign and local researchers, and reduce the carbon-footprint of collection-based research. This study offers a promising validation of a collaborative research design whereby researchers remotely work together to produce comparable data capturing lithic shape variability.
Exponential Decay for a Klein-Gordon-Schrödinger System with locally Distributed Damping
Authors: Poulou M. , Filippakis M. , Zanchetta J. 
Published: June 2022

Abstract
The following coupled damped Klein-Gordon-Schrödinger equations are considered iψt + κψxx + iαb(x)ψ = φψχ(ω), φtt − φxx + φ + λ(x)φt = −Reψxχ(ω), where Ω is a bounded domain of R, with smooth boundary Γ and ω is a neighbourhood of ∂Ω satisfying the geometric control condition. The aim of the paper is to prove the existence, uniqueness and uniform decay for the solutions following the ideas presented in the works of [1] and [2]. Mathematics Subject Classification (2010). 35B40, 35B45, 35Q55.
Experimental Velocity Fields Evaluation under the Rotor/Propeller Interactions for High Speed Helicopters for Different Propeller Positions
Authors: LEFEVRE Lauriane , NOWINSKI Vianney , DELVA Jerome , DAZIN Antoine 
Published: June 2022

Abstract
This paper focuses on the experimental evaluation of the rotor/propeller interactions for hybrid compound configurations. Experiments are conducted in the ONERA L2 large size-low speed wind tunnel with a 1/7.7 Dauphin 365N model and a four-bladed small-scale propeller. PIV measurements are performed to visualize the velocity fields around the helicopter. Different flight conditions (wind speeds, and propeller position) are tested. In hover, the propeller is completely immersed in the rotor wake for all the configurations, and the thrust is therefore maximal. At low speed, the propeller is partially immersed and the flow on the propeller disk is highly asymmetrical. In this flight configuration, moving the propeller towards the tail of the device increases the interactions and thus the performances of the propeller. No direct interactions of the two rotating parts are measured at high speed for all the configurations tested.
Multi-cohort analysis of depression-associated gut microbiota sheds insight on bacterial biomarkers across populations
Authors: Liang Suisha , Sin Zhen Ye , Yu Juelei , Zhao Shilin , Xi Zhang , Bruzzone Roberto , Tun Hein 
Published: June 2022

Abstract
Gut microbes are associated with the development of depression based on extensive evidence. However, previous studies have led to conflicting reports on this association, posing challenges to the application of the gut microbiota in the diagnostics and treatment of depression. To minimize heterogenicity in data analysis, the present meta-analysis adopted a standardized bioinformatic and statistical pipeline to analyze 16s rRNA sequences of 1827 samples from 8 different cohorts. Although changes in the overall microbial community were identified by our meta-analysis, depressive-correlated changes in alpha-diversity were absent. Enrichment of Bacteroidetes, Parabacteroides, Barnesiella, Bacteroides, Alistipes inops, Bacteroides massiliensis, along with depletion in Firmicutes, Dialister and Bacteroides plebeius were observed in depressive-associated microbiota. By contrast, elevated L-glutamine degradation and reduced L-glutamate production and L-isoleucine biosynthesis were identified in depressive-associated microbiome. After systemically reviewing the data of these collected cohorts, we have established a microbial classifier to identify depressive symptoms with AUC > 78%. Moreover, a low-risk microbial cluster for depressive symptoms was identified, which presented by a lower abundance of Escherichia-Shigella, and a higher abundance of Faecalibacterium, Oscillospiraceae UCG 002, Ruminococcus and Christensenellaceae R.7 group.
Identification and validation of a hypoxia-immune related prognostic signature for pancreatic cancer
Authors: Qinhong Xu , Ganghua yang , Fandi Meng , Yong Wan , Zhengyang Lu , Xuqi Li 
Published: June 2022

Abstract
Pancreatic cancer remains a lethal disease with poor prognosis. Immune and hypoxia are critical characteristics of tumor microenvironment, and are closely associated with cancer prognosis. Present study aimed to identify a novel hypoxia-immune related gene signature for prediction of prognosis in pancreatic cancer. The status of hypoxia or immune was identified with NMF method with the data from TCGA database. Total 27 differentially expressed genes related with hypoxia or immune was screened out. A 6-gene prognostic signature (GALR2, AGT, MAPT, PRKCG, CAMK2B and PKP1) related with hypoxia-immune was further identified by LASSO regression. The survival analysis showed that the overall survival of patients with pancreatic cancer is inversely associated with prognosis signature. ROC curve indicated the excellent performance of the prognostic signature with AUC of 0.713. The similar prognosis value of the prognostic signature was further validated in 2 GEO independent cohort. In addition, the nomogram was constructed with the prognosis signature and clinical factors including gender, age and histology grade, and the performance of nomogram was accessed by calibration plots and decision curve analysis. Therefore, our study identified a hypoxia-immune related prognostic signature and established a nomogram, which may be helpful for survival prediction in patents with pancreatic cancer.
Antispasmodic activity of novel 2,4-dichloroanilinium perchlorate hybrid material (I): X-ray crystallography, DFT studies, and molecular docking approach
Authors: Jaziri Emna , Louis Hitler , Gharbi Chaima , Unimuke Tomsmith O. , Agwamba Ernest C. , Mathias Gideon E. , Fugita Wataru , Nasr Chérif Ben , Khedhiri Lamia 
Published: June 2022

Abstract
The intriguing properties of organic-inorganic hybrid materials has resulted in the recent upsurge for more effective hybrid materials with diverse activity, harnessing the advantage of the flexibility and structural diversity imposed by these materials. In line with these, the synthesis, crystallography and structural characterization of a novel perchlorate (2,4-dichloroanilinium perchlorate) organic-inorganic hybrid material is reported. The synthesized structure was characterized by FTIR and NMR techniques. Appropriate computational methods were utilized to correlate the experimentally observed spectroscopic properties as well as other molecular electronic properties. The computational studies were achieved at the DFT/M06-2X/6-311++G(2df,2dp) and aug-cc-pVTZ level of theory. For benchmarking purposes, the PWPB95 functional with D3BJ dispersion correction was utilized. Molecular electronic properties such as the frontier molecular orbitals, Natural bond orbital analysis, Hirshfeld surface analysis, and visual study of weak interaction via non-covalent interaction were considered to understand the molecular diversity of the perchlorate cluster. Hybrid materials often pose diverse bio-activities and as such the anti-spasmodic activity of the studied compound is considered by molecular docking approach.
Process, structural and outcome quality indicators to support perioperative opioid stewardship for patients with bowel cancer; a rapid review
Authors: Thomas Caroline , Ayres Michael , Pye Kate , Yassin Dina , Howell Simon J , Alderson Sarah 
Published: June 2022

Abstract
Opioids are effective analgesics but can cause harm. Opioid stewardship is key to ensuring that opioids are used effectively and safely. There is no agreed set of quality indicators relating to the use of opioids perioperatively. This work is part of the Yorkshire Cancer Research Bowel Cancer Quality Improvement programme and aims to develop useful quality indicators for the improvement of care and patient outcomes at all stages of the perioperative journey. A rapid review was performed to identify original research and reviews in which quality indicators for perioperative opioid use are described. A data tool was developed to enable reliable and reproducible extraction of opioid quality indicators. A review of 628 abstracts and 118 full-text publications was undertaken. Opioid quality indicators were identified from 47 full-text publications. In total, 128 structure, process and outcome quality indicators were extracted. Duplicates were merged, with the final extraction of 24 discrete indicators. These indicators are based on five topics; patient education, clinician education, pre-operative optimisation, procedure and patient specific prescribing and de-prescribing and opioid-related adverse drug events. The quality indicators are presented as a toolkit to contribute to practical opioid stewardship. Process indicators were most commonly identified and contribute most to quality improvement. Fewer quality indicators relating to intraoperative and immediate recovery stages of the patient journey were identified. An expert clinician panel will be convened to agree which of the quality indicators identified will be most valuable in our region for the management of patients undergoing surgery for bowel cancer.
Data-Driven Quantum Approximate Optimization Algorithm for Cyber-Physical Power Systems
Authors: Jing Hang , Wang Ye , Li Yan 
Published: June 2022

Abstract
Quantum technology provides a ground-breaking methodology to tackle challenging computational issues in power systems, especially for Distributed Energy Resources (DERs) dominant cyber-physical systems that have been widely developed to promote energy sustainability. The systems’ maximum power or data sections are essential for monitoring, operation, and control, while high computational effort is required. Quantum Approximate Optimization Algorithm (QAOA) provides a promising means to search for these sections by leveraging quantum resources. However, its performance highly relies on the critical parameters, especially for weighted graphs. We present a data-driven QAOA, which transfers quasi-optimal parameters between weighted graphs based on the normalized graph density, and verify the strategy with 39, 774 instances. Without parameter optimization, our data-driven QAOA is comparable with the Goemans-Williamson algorithm. This work advances QAOA and pilots the practical application of quantum technique to power systems in noisy intermediate-scale quantum devices, heralding its next-generation computation in the quantum era.
Combining blinatumomab and donor lymphocyte infusion in B-ALL patients relapsing after allogeneic hematopoietic cell transplantation: A study of the SFGM-TC
Authors: Chauvet Paul , Paviglianiti Annalisa , Labopin Myriam , labussiere helene , Boissel Nicolas , Robin Marie , Maillard Natacha , Ouachée-Chardin Marie , Forcade Edouard , Poiré Xavier , Chantepie Sylvain , Huynh Anne , BULABOIS Claude-Eric , Leclerc Mathieu , Maury Sébastien , Chevallier Patrice , Cluzeau Thomas , Mear Jean-Baptiste , Cornillon Jerome , Bilger Karin , SIMAND Celestine , Beguin Yves , Rubio Marie-Thérèse , yakoubagha ibrahim , Brissot Eolia 
Published: June 2022

Abstract
Relapsed B-cell acute lymphoblastic leukemia (B-ALL) after allogeneic stem cell transplantation (allo-HCT) still represents a major concern with poor outcomes. The aim of this study is to compare the efficacy and safety of blinatumomab and donor lymphocyte infusion (DLI) versus blinatumomab alone in this setting. This is a multicenter retrospective study from centers of SFGM-TC. All transplanted patients who received blinatumomab salvage therapy were included. Patients who received DLI from 1 month before to 100 days after the starting of blinatumomab were included in the blina-DLI group. Seventy-two patients were included. Medium follow-up was 38 months. Fifty received blinatumomab alone and 22 the association blinatumomab-DLI. Two-year overall survival (OS) was 31% in the blinatumomab group and 43% in the blinatumomab-DLI group (p=0.31). Studying DLI as a time dependent variable, PFS did not significantly differ between the 2 groups (HR:0.7, 95%CI:0.4-1.5). In multivariate analysis, DLI was not a prognostic factor for OS, progression-free survival and progression/relapse incidence. Adverse events and graft-versus-disease rates were comparable in the 2 groups. In conclusion, adding DLI between 1 month before and 100 days after start of blinatumomab is safe and does not seem to improve outcomes in B-ALL patients who relapsed after allo-HCT.
Design and Analysis of a Welding Inspection Robot
Authors: zhang pengyu , Zhang Feng , Xu Pei-Quan , Li Lei-Jun 
Published: June 2022

Abstract
Periodic inspection of weld seam quality is an important step in assessing equipment safety. But this task requires personnel to perform inspection rounds. To save labor costs and improve efficiency, autonomous navigation and autonomous weld inspection robot are developed. The development process involves the design of chassis damping, target detection mechanism, and control system and algorithms. In particular, when performing weld inspection in complex outdoor environments, the robot is required to avoid any obstacles. The problem of planning the inspection route is solved by improving a timed elastic band (TEB) algorithm. The robot is capable of conducting inspection tasks in complex and dangerous environments efficiently.
Point of care-based design and developement of liposome-anchored Teriparatide incorporated gallic acid-grafted gelatin injectable hydrogel for osteoarthritis treatment
Authors: Guoqing Li , Liu Su , Chen Yixiao , Zhao Jing , Xu Huihui , Weng Jian , Yu Fei , Xiong Ao , Udduttula Anjaneyulu , Wang Deli , Liu Peng , Chen Yingqi , Hui Zeng 
Published: June 2022

Abstract
Intra-articular (IA) injection of drugs is an effective strategy in treating osteoarthritis disease. However, the rapid drug loss and high-frequency injections are the main issues. Hence, we verily efforts to design and develop a point of care-based new biofunctional hydrogel by nanoengineer and chemistry approach. In this study, a novel gallic acid-grafted gelatin injectable hydrogel loaded with liposomes-anchored teriparatide (GGA@Lipo@PTH: GLP) was developed with an enzyme-linking method to control PTH release, aimed to alleviate osteoarthritis progress and protect chondrocytes degradation. In vitro studies of the GLP hydrogel promoted ATDC5 proliferation and upregulation of key proteins expression in the PI3K/AKT signaling pathway. Further, in vivo IA injection results of GLP confirmed the controlled release of PTH, promotes the secretion of glycosaminoglycan and protects the cartilage from degradation in DMM mice. Therefore, our study explored that the developed novel GLP hydrogel could be an alternative potential biomaterial in the osteoarthritis treatment.
Multi-scale organization in communicating active matter
Authors: Ziepke Alexander , Maryshev Ivan , Aronson Igor , Frey Erwin 
Published: June 2022

Abstract
The emergence of collective motion among interacting, self-propelled agents is a central paradigm in non-equilibrium physics. Examples of such active matter range from swimming bacteria and cytoskeletal motility assays to synthetic self-propelled colloids and swarming microrobots. Remarkably, the aggregation capabilities of many of these systems rely on a theme as fundamental as it is ubiquitous in nature: communication. Despite its eminent importance, the role of communication in the collective organization of active systems is not yet understood. Here we report on the multi-scale self-organization of interacting self-propelled agents that locally process information transmitted between them by chemical signals. We show that this communication capacity greatly expands their ability to form complex structures, allowing them to self-organize through a series of collective dynamical states at multiple hierarchical levels. Our findings provide insights into the role of self-sustained signal processing for self-organization in biological systems, and open routes to applications using chemically driven colloids or microrobots.
Autologous protein solution injection for knee osteoarthritis: Comparison of clinical results by disease severity
Authors: Kuwasawa Ayano , Okazaki Ken , Noda Kuniko , Nihei Kotaro 
Published: June 2022

Abstract
Background: Autologous protein solution (APS) is made from platelet-rich plasma that extracts high-concentration growth factors and cytokines. Intra-articular APS injection was reported to improve knee osteoarthritis (KOA) pain and function. However, efficacy differences regarding osteoarthritis severity remained unknown.Methods: This retrospective study clinically assessed 228 knees with KOA in the Kellgren–Lawrence (KL) grades 2–4 that underwent APS injection using the Knee Injury and Osteoarthritis Outcome Score (KOOS). A telephone survey was performed for patients who dropped out to check symptom changes. The recalculated estimated responder rate included the telephone survey results.Results: The 12-month follow-up was completed with 154 knees (68%), whereas 74 knees dropped out. The follow-up rate was significantly lower in KL4 than KL2 and 3. The KOOS significantly improved in 154 knees, whereas the KOOS was lower in KL4 than in KL2. The responder rate was 56% total, 58% in KL2, 56% in KL3, and 51% in KL4; however, the estimated responder rate, including the telephone survey, was 48% total, 54% in KL2, 50% in KL3, and 39% in KL4.Conclusion: This study showed improved clinical symptoms 1-year after APS injections for KOA, with a lower responder rate in KL4 than in KL2 or KL3.
Analysis of the characteristics associated with hepatitis C virus infection in hospitals featuring infectious diseases: A retrospective study
Authors: Han Ying , Yin Shangqi , Zheng Mei , Meng Huan , He Chaonan , Han Jinyu , Chen Jin , Wang Yajie 
Published: June 2022

Abstract
Background: The hepatitis C virus infection is a high-risk factor for cirrhosis or hepatocellular carcinoma. However, since the majority of hepatitis C patients are asymptomatic or mildly symptomatic, they remain undetected with no timely treatment. In this study, we collected the data of patients positive for HCV antibodies and HCV-RNA from our hospital and analyzed the status and characteristics of hepatitis C virus infection in a hospital featuring infectious diseases.Methods: Data were obtained from patients admitted to Beijing Ditan Hospital between 2017 and 2020. The HCV antibodies and HCV-RNA positivity rates were compared among different age groups along with the age distribution of positive patients. In addition, HCV antibodies and HCV-RNA positivity rates, as well as inpatients HCV antibody detection rate, were analyzed between 2017 and 2020. Results: The average positivity rate (%) of HCV antibody was 6.78%, with the highest rate in the 50-59 age group. Whereas, the average positivity rate (%) of HCV-RNA testing was 24.08%, which showed a continuous increase with an increase in age. Patients aged 50–59 years comprised the highest number of patients with both HCV antibodies and HCV-RNA positivity. Women had a higher positivity rate of HCV antibodies than men (P<0.001). Between 2017 and 2020, the positivity rate (%) of HCV antibodies showed a continuous decrease from 7.6% to 6.24% (P<0.0001). Contrastingly, the positivity rate (%) of HCV-RNA showed a continuous increase from 22.03% to 26.58% (P = 0.0004). The detection rate of HCV antibodies in inpatients was 59.8%, while the positivity rate was 5.24%. While the detection rate showed an upward trend, the positivity rate showed a downward trend.Conclusions: Our hospital displayed a clustering effect on HCV-infected patients as well as on the high-risk group of people. Hence, there was a need to strengthen the awareness in patients for active screening of hepatitis C, especially in patients over 40 years of age. The population with age 50–59 was more susceptible to HCV infection and required more attention to hepatitis C screening. Furthermore, inpatient detection results should be completely used to ensure more visibility and on-time treatment of patients.
Isolation, diversity, and the evaluation of multi-trait plant growth promoting rhizobacteria associated to roots of saffron (Crocus sativus L.)
Authors: Chamkhi Imane , Laila Sbabou , Jamal Aurag 
Published: June 2022

Abstract
The cultivation of Crocus sativus L. (saffron) is of particular interest in view of the sale of this spice on the world market. It is a very popular product throughout the world, especially for its culinary and medicinal virtues. In order to maintain the quality of the product, the organic production method without chemical inputs should be maintained and improved by the application of organic fertilizers and biofertilizers based on beneficial micro-organisms such as plant growth-promoting rhizobacteria (PGPR), which are capable of boosting the productivity. In this context, a better knowledge of the microbial populations of the rhizosphere of saffron is needed. The isolation of rhizobacterial strains was carried out from saffron soil collected from Taliouine-Talakhat region (Morocco). Plant growth promoting traits (PGP) activities of these isolates were evaluated by measuring, auxin production, siderophore production, phosphate solubilization, biological nitrogen fixation, aminocyclopropane -1-carboxylate (ACC) deaminase activity, cellulose activity, and antagonistic activity. Moreover, molecular identification of the isolates was determined by using 16S rDNA gene sequencing. Results showed that a collection of 88 bacteria strains were isolated from rhizospheric soils. The evaluation of PGP of these isolates showed that most of them possessed one or more PGP activity studied. The molecular identification of the isolates by 16S rDNA gene sequencing revealed eight genera: Pseudomonas, Rahnella, Variovorax, Delftia, Bacillus, Rhizobium, Luteibacter, and Pantoea, while, Pseudomonas was the most abundant genus. The findings of this study suggest that the isolates with higher levels of PGP activities can be used for the conception of bacterial biofertilizers that will be applied in saffron field inoculation trials.