bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of a fractional plankton–fish model under the influence of toxicity, refuge, and combine-harvesting efforts
Authors: Premakumari R. N. , Baishya Chandrali , Kaabar Mohammed K. A. 
Published: November 2022

AbstractIn this work, we analyze plankton–fish dynamics in the presence of toxicity, refuge, and combine-harvesting efforts by a considering Holling type-II functional response. We have considered phytoplankton, zooplankton, and fish populations, and the interdependent evolution is presented with the help of the Caputo fractional derivative. Since toxicity in phytoplankton spreads to zooplankton and hence to fish, we have introduced toxic terms in all the populations. On the other hand, to save the population from extinction harvesting is an essential tool. Theoretical aspects are studied in terms of nonnegativity, boundedness, existence, and uniqueness of the solution. Sufficient conditions are derived for the stability of various points of equilibrium. The composite behavior is studied by varying the values of different parameters and fractional derivatives. Numerical simulations are carried out to strengthen the theoretical findings.
RHO GTPase family in hepatocellular carcinoma
Authors: Wang Tiantian , Rao Dean , Yu Chengpeng , Sheng Jiaqi , Luo Yiming , Xia Limin , Huang Wenjie 
Published: November 2022

AbstractRHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly conserved in eukaryotic species and have important biological functions, including actin cytoskeleton reorganization, cell proliferation, cell polarity, and vesicular transport. Recent studies indicate that RHO GTPases participate in the proliferation, migration, invasion and metastasis of cancer, playing an essential role in the tumorigenesis and progression of hepatocellular carcinoma (HCC). This review first introduces the classification, structure, regulators and functions of RHO GTPases, then dissects its role in HCC, especially in migration and metastasis. Finally, we summarize inhibitors targeting RHO GTPases and highlight the issues that should be addressed to improve the potency of these inhibitors.
Targeting Bruton’s tyrosine kinase in vitreoretinal lymphoma: an open-label, prospective, single-center, phase 2 study
Authors: Guan Wenxue , Wang Liang , Peng Xiaoyan 
Published: November 2022

AbstractVitreoretinal lymphoma (VRL) is strongly linked to central nervous system (CNS) progression with no standard treatment approaches. Commonly used strategies include repeated intraocular injections of low-dose methotrexate or local radiotherapy, with great inconvenience, long-term side effects, and high risk of CNS relapse. In this study, we evaluated the efficacy and safety of bruton’s tyrosine kinase inhibitors (BTKi) in the treatment of VRL. This prospective single-center study enrolled patients with relapsed or newly diagnosed VRL between October 2020 and April 2022. Patients received BTKi monotherapy until disease progression or unacceptable toxicity. The primary endpoint was the disease control (DC) rate after one month of treatment; secondary endpoints include toxicity, overall survival (OS), and progression-free survival (PFS). Ten consecutive patients with VRL were enrolled into this study. After 1-month treatment, 9 patients (90%) achieved a DC, with 7 patients (70%) achieving a complete response (CR). With a median follow-up of 8.3 (2.5–21.4) months, 4 patients were confirmed to have disease progression, with a PFS of 1.2, 7.5, 9.1, and 11.6 months, respectively. The remaining 6 patients have durable control of disease and were still on treatment at time of the analysis. BTKi were well-tolerated and no patients discontinued the drug because of adverse events. In conclusion, targeting BTK in VRL is viable, and our findings could pave the way for a paradigm change in VRL therapy choices. Further large-scale studies, however, are required to give stronger evidence about the efficacy and safety.
Aligned nanofibrous collagen membranes from fish swim bladder as a tough and acid-resistant suture for pH-regulated stomach perforation and tendon rupture
Authors: Luan Zhaohui , Liu Shuang , Wang Wei , Xu Kaige , Ye Shaosong , Dan Ruijue , Zhang Hong , Shu Zhenzhen , Wang Tongchuan , Fan Chaoqiang , Xing Malcolm , Yang Shiming 
Published: November 2022

Abstract

Background
Wound closure in the complex body environment places higher requirements on suture’s mechanical and biological performance. In the scenario of frequent mechanical gastric motility and extremely low pH, single functional sutures have limitations in dealing with stomach bleeding trauma where the normal healing will get deteriorated in acid. It necessitates to advance suture, which can regulate wounds, resist acid and intelligently sense stomach pH.

Methods
Based on fish swim bladder, a double-stranded drug-loaded suture was fabricated. Its cytotoxicity, histocompatibility, mechanical properties, acid resistance and multiple functions were verified. Also, suture’s performance suturing gastric wounds and Achilles tendon was verified in an in vivo model.

Results
By investigating the swim bladder’s multi-scale structure, the aligned tough collagen fibrous membrane can resist high hydrostatic pressure. We report that the multi-functional sutures on the twisted and aligned collagen fibers have acid resistance and low tissue reaction. Working with an implantable “capsule robot”, the smart suture can inhibit gastric acid secretion, curb the prolonged stomach bleeding and monitor real-time pH changes in rabbits and pigs. The suture can promote stomach healing and is strong enough to stitch the fractured Achilles tendon.

Conclusions
As a drug-loaded absorbable suture, the suture shows excellent performance and good application prospect in clinical work.
Synthesis of Two Macrocyclic Fragments of Manadomanzamine Alkaloids
Authors: Kurihara Yuki , Azuma Atsushi , Yasufuku Haruka , Takikawa Shinsaku , Chida Noritaka , Sato Takaaki 
Published: November 2022

Abstract
The synthesis of two macrocyclic fragments in the manadomanzamine alkaloids based on a strategy using reductive nucleophilic addition to macrolactams is reported. The sequence through the Wittig coupling and macrolactamization gives quick access to both eleven-membered and ten-membered macrolactams. The iridium-catalyzed reductive Strecker reaction of the ten-membered macrolactam takes place via the corresponding unstable imine intermediate.
Ηθικά ζητήματα από τη διαλειτουργικότητα στον ηλεκτρονικό φάκελο υγείας
Authors: Χασιώτης Ηρακλής , Χασιώτη Ευαγγελία-Ζωή 
Published: November 2022

Η υιοθέτηση ηλεκτρονικών συστημάτων στην υγειονομική περίθαλψη μέσω των Τεχνολογιών Πληροφοριακών Συστημάτων (ΤΠΕ) οδήγησε στην αύξηση της ποιότητας της παρεχόμενης υγείας, τη δημιουργία, συλλογή, μεταφορά και αποθήκευση των δεδομένων υγειονομικής περίθαλψης καθώς και την ανάκτηση τους από εξουσιοδοτημένους επαγγελματίες υγείας. Η χρήση των ΤΠΕ οδηγεί στην μείωση των ιατρικών λαθών, στην μείωση του κόστους, στην άμεση ανάκτηση δεδομένων οποιαδήποτε στιγμή και σε οποιοδήποτε σημείο και τέλος στην ικανοποίηση των ασθενών. Η μετακίνηση των ασθενών μεταξύ διαφορετικών παρόχων υγειονομικής περίθαλψης οδηγεί στην ανάγκη ηλεκτρονικών τρόπων καταγραφής εξετάσεων και αναφορών προκειμένου να μπορούν να ανακτηθούν όποτε κρίνεται αναγκαίο. Η διαλειτουργικότητα των πληροφοριακών συστημάτων μεταξύ τους για την έγκαιρη πρόσβαση σε πληροφορίες των ασθενών όπως ο Ατομικός Ηλεκτρονικός Φάκελος Ασθενούς (ΑΗΦΥ) που εμπεριέχει πληροφορίες όπως το ιστορικό, τις διαγνώσεις, τις ιατρικές και απεικονιστικές εξετάσεις κρίνεται αναγκαία για την ασφάλεια των δεδομένων.
Ωστόσο εγείρονται πολλές ηθικές προκλήσεις όπως η εμπιστευτικότητα της διακίνησης των δεδομένων, ο έλεγχος στην πρόσβαση και ανάκτηση αυτών, η προσβολή της ιδιωτικής ζωής, η αποθήκευση, η διατήρηση και διανομή των δεδομένων.
Η συζήτηση και οι συστάσεις που πρέπει να λαμβάνουν χώρα αφορούν την ενημερωμένη συναίνεση των ασθενών και το δικαίωμα της αυτονομίας, την ασφάλεια των προσωπικών δεδομένων μέσω του Γενικού Κανονισμού Προσωπικών Δεδομένων (GDPR- ν. 2016/679), την εξασφάλιση Ποιότητας καθώς και τον σχεδιασμό ασφαλούς και ολοκληρωμένου τρόπου διαλειτουργικότητας των συστημάτων υγειονομικής περίθαλψης και πώς μπορούν να αντιμετωπιστούν.
Albumin to prealbumin ratio in peritoneal dialysis patients: Clinical implication and outcome prediction
Authors: Huang Yun-Ting , Jiang Ming-Yan , Hwang Jyh-Chang 
Published: November 2022

Background
Serum prealbumin level is slightly higher, whereas albumin is lower in peritoneal dialysis (PD) than hemodialysis (HD) patients. It is unknown whether albumin to prealbumin ratio (APR) is associated with mortality risk among PD patients. This study aimed to evaluate the clinical implications of APR and its prediction value on long-term outcomes of PD patients.

Methods
The study population were prevalent PD patients at a tertiary hospital. Based on APR, a total of 220 PD patients were divided into 3 groups: group 1: top tertile, median APR: 121.1; IQR:109.5–131.9 (n = 73, male: 37%; age: 59±13); group 2: middle tertile, median APR: 97.1; IQR 93.5–100.0 (n = 73, male:37%; age: 54±14), and group3: bottom tertile, median APR: 81.3; IQR:76.8–85.0 (n = 74, male:38%; 54±11). Patients were followed up for a maximum of 5 years. Outcome of interest was all-cause mortality.

Results
Group 1 was characterized by older age, higher prevalence of diabetes, lower nPCR, higher Davies score and hs-CRP level. APR positively correlated to hs-CRP (β = 0.149, p = 0.045), but negatively correlated to nPCR (β = -0.161, p = 0.034). Hyperprealbuminemia, accounting for 0%, 23.3%, and 82.4% in groups 1,2, and 3, was associated with a lower risk for mortality (HR:0.41, 95%CI = 0.23–0.73). The cumulative survival is significantly lower in group 1 than the other two groups. By multivariable Cox regression, APR (HR:1.02; 95%CI:1.01–1.03) was found to be an independent predictor of long-term mortality.

Conclusion
PD patients with high APR are characterized by having more comorbidities and marked malnutrition-inflammation status, and are associated with long-term mortality, whereas hyperprealbuminemia and lower APR are favorable prognostic factors.
Spontaneous pneumothorax in a child with miliary tuberculosis: a case report
Authors: Shodikin Muhammad Ali , Agustina Dini 
Published: November 2022

Spontaneous pneumothorax is a rare but fatal complication of miliary tuberculosis. We report a 13-year-old boy presenting with shortness of breath. He was diagnosed with miliary tuberculosis with spontaneous pneumothorax, which showed significant improvement after the insertion of a thoracostomy tube and anti-tuberculosis drug therapy.
Measurement of internal diameters of capillaries and glass syringes using gravimetric and optical methods for microflow applications
Authors: Batista Elsa , Álvares Miguel , Martins Rui F. , Ogheard Florestan , Geršl Jan , Godinho Isabel 
Published: November 2022

Abstract

Objectives
Microflow measurement devices are used in several science and health applications, mainly drug delivery. In the last decade, several new methods based on optical technology were developed, namely the front tracking and interferometric method, in which the knowledge of the inner diameter of the syringe or the capillary used is critical. Only a few National Metrology Institutes (NMIs) can perform inner diameter measurements below 1 mm, which requires expensive technology. Therefore, IPQ, in cooperation with CETIAT, CMI and UNIDEMI, under the EMPIR project 18HLT08 MeDDII – Metrology for Drug Delivery, developed new measurement methods for small inner diameter tubes based on the gravimetric principle and optical methods in order to simplify the apparatus used for this type of measurements without increasing uncertainty.

Methods
The gravimetric experimental setup consists of measuring the liquid volume on a specific length of the glass tube. The optical method used is based on the front track principle that uses a high-resolution camera and ImageJ software, to determine the diameter at both ends of each capillary.

Results
To validate the developed methods, a comparison was performed between CETIAT, CMI and IPQ and the results obtained were all consistent.

Conclusions
This work allowed the determination of inner diameter of syringes or capillaries using two different methods with relative expanded uncertainties from 0.1 to 0.5% (k=2), that can be applied for flow measurements using optical technology.
Time to address quality control processes applied to antibody testing for infectious diseases
Authors: Dimech Wayne J. , Vincini Giuseppe A. , Plebani Mario , Lippi Giuseppe , Nichols James H. , Sonntag Oswald 
Published: November 2022

Abstract
As testing for infectious diseases moves from manual, biological testing such as complement fixation to high throughput automated autoanalyzer, the methods for controlling these assays have also changed to reflect those used in clinical chemistry. However, there are many differences between infectious disease serology and clinical chemistry testing, and these differences have not been considered when applying traditional quality control methods to serology. Infectious disease serology, which is highly regulated, detects antibodies of varying classes and to multiple and different antigens that change according to the organisms’ genotype/serotype and stage of disease. Although the tests report a numerical value (usually signal to cut-off), they are not measuring an amount of antibodies, but the intensity of binding within the test system. All serology assays experience lot-to-lot variation, making the use of quality control methods used in clinical chemistry inappropriate. In many jurisdictions, the use of the manufacturer-provided kit controls is mandatory to validate the test run. Use of third-party controls, which are highly recommended by ISO 15189 and the World Health Organization, must be manufactured in a manner whereby they have minimal lot-to-lot variation and at a level where they detect exceptional variation. This paper outlines the differences between clinical chemistry and infectious disease serology and offers a range of recommendations when addressing the quality control of infectious disease serology.
Analysis and modeling of pitaya slices in a heat pump drying system
Authors: Zhang Zhenya , Han Lucong , Jin Tingxiang 
Published: November 2022

Abstract
The objective of this article was to investigate the drying kinetics, effective moisture diffusivity, and quality of pitaya in the heat pump drying process. The experiment was conducted at a drying temperature of 50–70°C, slice thickness of 8–10 mm, and a relative humidity of 10–30%. The results showed that the heat pump drying of pitaya was a deceleration process. The drying temperature has the greatest influence on the drying rate. The drying time decreased by 28.57% with the drying temperature increased from 50 to 70°C, while that increased the least by 12% with the slice thickness dropped from 10 to 8 mm. Six drying models were analyzed comparatively based on experimental data, and calculations indicated that the Avhad and Marchetti model could better describe the moisture migration law during the heat pump drying process of pitaya. The optimal drying kinetics model was established to predict the change of moisture content under different drying conditions, and the average error of the model compared with the experimental values was 5.56%. In addition, the effective moisture diffusivity of pitaya ranged from 6.4167 × 10−10 to 9.8156 × 10−10 m2/s, and the drying temperature had a remarkable influence on the effective moisture diffusivity while the slice thickness had the least. According to the Arrhenius equation, the drying activation energy of pitaya under the experimental conditions was 19.628 kJ/mol. Moreover, the effect of drying temperature on browning degree and surface microstructure was also analyzed. The conclusions of this article provide theoretical support for the analysis of water migration laws and the optimization of the pitaya heat pump drying process.
Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis
Authors: Mukhtar Tanzila , Breda Jeremie , Adam Manal A , Boareto Marcelo , Grobecker Pascal , Karimaddini Zahra , Grison Alice , Eschbach Katja , Chandrasekhar Ramakrishnan , Vermeul Swen , Okoniewski Michal , Pachkov Mikhail , Harwell Corey C , Atanasoski Suzana , Beisel Christian , Iber Dagmar , van Nimwegen Erik , Taylor Verdon 
Published: November 2022

AbstractThe cerebral cortex contains billions of neurons, and their disorganization or misspecification leads to neurodevelopmental disorders. Understanding how the plethora of projection neuron subtypes are generated by cortical neural stem cells (NSCs) is a major challenge. Here, we focused on elucidating the transcriptional landscape of murine embryonic NSCs, basal progenitors (BPs), and newborn neurons (NBNs) throughout cortical development. We uncover dynamic shifts in transcriptional space over time and heterogeneity within each progenitor population. We identified signature hallmarks of NSC, BP, and NBN clusters and predict active transcriptional nodes and networks that contribute to neural fate specification. We find that the expression of receptors, ligands, and downstream pathway components is highly dynamic over time and throughout the lineage implying differential responsiveness to signals. Thus, we provide an expansive compendium of gene expression during cortical development that will be an invaluable resource for studying neural developmental processes and neurodevelopmental disorders.
GAMBARAN STATUS GIZI, AKTIVITAS FISIK, DAN PENYELENGGARAAN MAKANAN UNTUK KARYAWAN HOTEL
Authors: Gunawan Afira Septia 
Published: November 2022

Manajemen penyelenggaraan makan akan menunjang status gizi untuk tenaga kerja. Ketersediaan makanan harus memenuhi kebutuhan gizi tenaga kerja dan terjamin keamanannya. Asupan gizi pada pekerja akan berbanding lurus dengan status gizi pekerja yang dapat digambarkan melalui Indeks Massa Tubuh (IMT) normal pada rentang nilai 18,5 hingga 25. Penelitian ini bertujuan untuk mendeskripsikan status gizi, aktivitas fisik, fungsi dan manfaat penyelenggaraan makan pada karyawan di 16 hotel berbeda. Penelitian ini menggunakan metode observasional (non eksperimental) dengan pendekatan semi kuantitatif. Data diperoleh secara langsung dan virtual melalui metode wawancara dan pengukuran antropometri sehingga jenis data yang digunakan adalah data primer dan sekunder. Instrumen yang digunakan adalah microtoise, timbangan berat badan, hasil laporan medical check-up, dan formulir FFQ semi kuantitatif. Jumlah sampel terdiri dari 16 karyawan hotel dengan jabatan dan tingkat aktifitas fisik berbeda. Terdapat 15 hotel melaksanakan sistem penyelenggaraan makan dan 1 hotel mengganti dengan uang makan. Berdasarkan hasil perhitungan menunjukkan terdapat 5 orang (31,25%) yang memiliki IMT kurus dan 11 orang (68,75%) memiliki IMT normal. Dengan rata-rata waktu kerja karyawan hotel 8 jam/hari maka dibutuhkan energi dari makanan yaitu 2/5 (40%) dari total kebutuhan kalori sehari.
Hubungan frekuensi latihan dengan hasil ketepatan mendarat atlet paralayang jawa tengah pada kejuaraan PON XX papua
Authors: Diantono Kris 
Published: November 2022

Tujuan penelitian ini untuk mengetahui ada atau tidaknya hubungan frekuensi latihan dengan hasil ketepatan mendarat. Jenis penelitian ini adalah kuantitatif dengan menggunakan metode penelitian non eksperimen. Metode pengumpulan data menggunakan, penyebaran angket atau kuisioner. Teknik analisis data dalam penelitian ini menggunakan analisis univariat dan bivariate. Subjek penelitian ini meliputi 6 atlet putra dan 2 atlet putri. Hasil penelitian menunjukan bahwa nilai Sig. (-tailed) sebesar 0,650 yang artinya > 0,05. Jika dilihat dari nilai person correlation (r) yaitu 0,191 yang artinya korelasi antar variable sangat lemah. Simpulan hasil penelitian ini yaitu bahwa korelasi antar variable sangat lemah. Hal ini menunjukan bahwa frekuensi latihan tidak memberi pengaruh terhadap ketepatan mendarat atlet paralayang.

Kata Kunci: Frekuensi Latihan, Ketepatan Mendarat, Paralayang.
Hubungan Tingkat Kecukupan Energi dan Zat Gizi Makro Dengan Kebugaran (Vo2 Maks) Atlet Sepakbola Di SAFIN Pati Football Academy
Authors: Amaliana Raisya 
Published: November 2022

Kebugaran seorang atlet menjadi salah satu faktor penentu tercapainya prestasi. Dalam permainan sepakbola kapasitas kebugaran atlet dapat ditentukan menggunakan VO2Maks. Faktor yang mempengaruhi VO2Maks diantaranya pengaturan makan, istirahat, dan latihan. Pengaturan makanan atlet ditentukan oleh kecukupan energi dan zat gizi makro. Penelitian ini bertujuan untuk mengetahui adanya hubungan tingkat kecukupan energi dan zat gizi makro dengan kebugaran (VO2Maks) atlet sepakbola di Safin Pati Football Academy (SPFA). Penelitian dilakukan secara analitik observasional dengan rancangan cross sectional. Diambil data asupan energi dan zat gizi makro atlet SPFA menggunakan metode Food Recall 3x24 jam pada 3 hari berbeda, kemudian data VO2Maks diperoleh melalui metode Yo-yo Test. Dengan jumlah responden 57 siswa yang ditentukan secara purposive sampling. Analisis data dilakukan dengan menggunakan Uji Pearson Product Moment. Hasil uji Pearson menunjukan adanya hubungan signifikan antara tingkat kecukupan energi (p<0,05; r=0,288), lemak (p<0,05; r=0,265), dan karbohidrat (p<0,05; r=0,264) dengan VO2Maks. Tidak ditemukan adanya hubungan signifikan antara kecukupan lemak (p>0,05; r=0,170) dengan VO2Maks. Terdapat hubungan yang signifikan antara tingkat kecukupan energi, lemak dan karbohidrat dengan VO2Maks atlet sepakbola di SPFA. Tidak terdapat hubungan yang signifikan antara tingkat kecukupan protein dengan VO2Maks atlet sepakbola SPFA.
Роль дипломатії під час воєнного стану
Authors: Федорова Ганна 
Published: November 2022

Актуальність. Дослідження ролі дипломатії під час воєнного стану є актуальним із огляду на жорстокість та масштабність російського вторгнення до України, що ставить перед дипломатією виклики щодо досягнення безпеки України у довгостроковій перспективі шляхом залучення сторонніх країн-гарантів, та зважаючи на загрозу на тлі російсько-української війни загострення безпекової ситуації у світі на порозі Третьої світового війни.
Метою дослідження є визначення ролі дипломатії під час воєнного стану. У дослідженні застосовано наступні методи дослідження: формально-логічний, структурно-функціональний, комплексний, юридичного аналізу, логічний та інші, які дозволили комплексно та всебічно дослідити проблемні питання досліджуваної теми.
У процесі дослідження отримано такі результати: визначено сучасні тенденції дипломатії; визначено специфіку дипломатії конфлікту; визначено особливості дипломатії під час воєнного стану, визначено особливості дипломатії під час воєнного стану в Україні. Наразі дипломатичні зусилля вітчизняного дипломатичного корпусу, президента та уповноважених посадових осіб передусім спрямовані на 3 напрямки: посилення санкцій; формування програми економічної підтримки України (за прикладом Плану Маршала); забезпечення військової та економічної допомоги.
У ході дослідження зроблені наступні висновки: внесок дипломатів є не меншим, ніж внесок військових безпосередньо на лінії фронту. Адже надання військової зброї у потрібних обсягах та потрібного виду та її фінансування повністю віднесено до пріоритетних завдань дипломатії. Після закінчення військових дій потребуватимуть додаткових досліджень ефективність роботи дипломатії та її роль із огляду на досягнуті результати, які можна буде оцінити після підписання угоди по зупиненню військових дій або перемир’я. У той же час необхідно відзначити, що і сам факт зупинення війни разом із наявністю гарантій безпеки та недопущення повторення вторгнення теж буде результатом роботи дипломатії вже у період після гострої фази.