bluuebunny/crossref_metadata_2025_split huggingface dataset:
De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia
Authors: Vial Yoann , Lainey Elodie , Leblanc Thierry , Baudouin Véronique , Dourthe Marie Emilie , Gressens Pierre , Verloes Alain , Cavé Hélène , Drunat Séverine 
Published: September 2022

SummaryIn a patient with severe microcephaly, congenital bone marrow failure, growth retardation, and renal hypoplasia, we identified a likely pathogenic variant in NUF2 that impairs the cell's ability to properly complete mitosis. Interestingly, these clinical features as well as the observed cellular alterations are highly reminiscent of what is reported in Fanconi Anaemia supporting a unifying causal role of the variant in the disease. This case provides the first evidence that a kinetochore defect, previously associated with microcephaly, can be responsible for an inherited bone marrow failure syndrome, highlighting the unique pathological link between neurogenesis and haematopoiesis.
Disparities in spatial accessibility to public dental services relative to estimated need for oral health care among refugee populations in Victoria
Authors: Veginadu Prabhakar , Gussy Mark , Calache Hanny , Masood Mohd 
Published: September 2022

AbstractObjectivesTo examine the spatial accessibility to public dental services (PDS) relative to the estimated oral health needs of refugee populations within the state of Victoria, Australia.MethodsThe study employed enhanced two‐step floating catchment area method to measure spatial accessibility to PDS by driving and public transit modes at statistical area level 2 (SA2). Principal component analysis of select census‐derived socioeconomic variables specific to the refugee population was conducted to derive an area‐based indicator of refugee oral health needs, also at SA2 level. Individual indices were then developed for each of these components using standardized z‐scores. Finally, an integrated need‐accessibility index was developed to identify low‐accessibility areas associated with high needs.ResultsThe results show clear contrast in spatial accessibility to PDS for the refugee populations between metropolitan and rural areas as well as between driving and public transit modes. There are critical limitations in accessibility for refugees living in the rural areas and those dependent on public transit mode for travel. Also, there is evident disparity between the estimated oral health needs of refugees in metropolitan and rural areas. Overall, approximately 29% of all SA2s with refugee population are in the ‘High’ needs category, which comprise 19.8% of the total Victorian refugee population. Integrating accessibility and oral health needs measures revealed that about 30% and 18% of refugee population are identified as under‐serviced, when considering driving and public transit modes respectively.ConclusionThe findings provide implications for researchers and policy makers to address the inequalities in access to PDS among the refugee population in Victoria. The methodology outlined in this study provides a complementary approach in planning oral health service provision in the absence of population level data at a small‐area scale on access to dental services or need for oral health care.
Outreach dental care program for older adults using residential care or day care services in Hong Kong: A cohort study
Authors: Yang Stella X. , Lo Edward C. M. , Leung Katherine C. M. 
Published: September 2022

AbstractAimTo evaluate the effects of an outreach dental care program (ODCP) on the oral health status and oral health‐related quality of life (OHRQoL) of older adults who used residential or day care services in Hong Kong.MethodsOlder adults who had received dental treatments provided in the ODCP were recruited. Clinical examinations were performed by one calibrated examiner (SXY) at baseline and 1‐year follow‐up in the residential homes or day care centres. Face‐to‐face interviews were conducted using the transition scale of the Oral Health Impacts on Daily Living (OHIDL) questionnaire to investigate the perceived change in OHRQoL at baseline, 2‐month and 1‐year follow‐ups. The Wilcoxon matched‐pair signed‐rank test or McNemar/McNemar‐Bowker test was used to explore the change in oral health status after dental treatments. Factors associated with the perceived change in OHRQoL were explored with binary logistic regression.ResultsFour hundred and thirteen older adults (mean age = 83.8 years) participated in the study at baseline, and 377 (91.3%) and 359 (86.9%) were successfully followed 2 months and 1 year after receiving the outreach dental service, respectively. At the 1‐year follow‐up, the number of decayed teeth and functional tooth units, and the prevalence of poor denture hygiene decreased while there was more dental plaque deposition and a higher proportion of participants with gingival bleeding upon probing. More than 50% of the participants perceived no change or an improvement in OHRQoL in all domains at both follow‐ups. Older adults who perceived their oral health status as ‘healthy or fair’ and those who suffered from toothache at baseline had a higher chance to perceive having a better or at least the same OHRQoL at the 2‐month and 1‐year follow‐ups, respectively.ConclusionsThe ODCP in Hong Kong can solve some of the dental problems of older adults using long‐term care services and keep most of them from deterioration in OHRQoL, especially those suffering from toothache.
Exclusion of Disperse Orange 3 is possible from the textile dye mix present in the Swedish baseline patch test series. A study by the Swedish Contact Dermatitis Research Group
Authors: Isaksson Marléne , Antelmi Annarita , Dahlin Jakob , Stenton Joanna , Svedman Cecilia , Zimerson Erik , Glas Bo , Hagvall Lina , Lagrelius Maria , Löwnertz Anna , Malinauskiene Laura , Matura Mihaly , Bruze Magnus 
Published: September 2022

AbstractBackgroundThe textile dye mix (TDM) 6.6% in petrolatum contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM‐positive patients is DO 3. Around 85% of para‐phenylenediamine (PPD)‐allergic dermatitis patients have been positive to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% because of strong simultaneous reactions to TDM and PPD.ObjectivesTo study if DO 3 can be excluded from TDM 6.6%.MethodsPatch tests were performed on 1481 dermatitis patients with TDM 6.6%, TDM 7.0% (without DO 3 but the other disperse dyes at 1.0% each), DO 3 1.0%, and PPD 1.0% pet.ResultsContact allergy to TDM 6.6% was 3.6% and to TDM 7.0% was 3.0%. All 26 DO 3‐positive patients were positive to PPD. The 44 patients positive to TDM 7.0% plus the 13 positive to PPD and TDM 6.6% but negative to TDM 7.0% were 57, outnumbering the 53 positive to TDM 6.6%.ConclusionTDM 7.0% can replace TDM 6.6% in the Swedish baseline series, since TDM 7.0% together with PPD 1.0% will detect patients with textile dye allergy.
Pain coping tools for children and young adults with a neurodevelopmental disability: A systematic review of measurement properties
Authors: Smith Nadine L. , Smith Meredith G. , Gibson Noula , Imms Christine , Thornton Ashleigh l. , Harvey Adrienne R. 
Published: September 2022

AbstractAimTo systematically identify and evaluate the measurement properties of patient‐reported outcome measures (PROMs) and observer‐reported outcome measures (parent proxy report) of pain coping tools that have been used with children and young adults (aged 0–24 years) with a neurodevelopmental disability.MethodA two‐stage search using MEDLINE, Embase, CINAHL, Web of Science, and PsycInfo was conducted. Search 1 in August 2021 identified pain coping tools used in neurodevelopmental disability and search 2 in September 2021 located additional studies evaluating the measurement properties of these tools. Methodological quality was assessed using the COnsensus‐based Standards for the Selection of Health Measurement INstruments (COSMIN) guidelines (PROSPERO protocol registration no. CRD42021273031).ResultsSixteen studies identified seven pain coping tools, all PROMs and observer‐reported outcome measures (parent proxy report) versions. The measurement properties of the seven tools were appraised in 44 studies. No tool had high‐quality evidence for any measurement property or evidence for all nine measurement properties as outlined by COSMIN. Only one tool had content validity for individuals with neurodevelopmental disability: the Cerebral Palsy Quality of Life tool.InterpretationPain coping assessment tools with self‐report and parent proxy versions are available; however, measurement invariance has not been tested in young adults with a neurodevelopmental disability. This is an area for future research.
The political economy of state economic development incentives: A case of rent extraction
Authors: Sobel Russell S. , Wagner Gary A. , Calcagno Peter T. 
Published: September 2022

AbstractThere is a large literature examining the macroeconomic effects of state economic development incentives on employment, income, tax revenue, and growth. At best, these incentives are found to be weakly effective at job creation, but inefficient due to the distortions, secondary effects, and increased rent‐seeking they encourage, with little public accountability. Given the evidence on their inefficiency, what explains their continued popularity? We find that large development incentives create substantial benefits for incumbent politicians in the form of both higher campaign contributions (particularly from business, labor, and construction sectors) and higher margins of victory at election time. Thus, political rent extraction may be the best explanation for the continued existence and popularity of these relatively ineffective incentive programs in states.
Headache persisting after aneurysmal subarachnoid hemorrhage: A narrative review of pathophysiology and therapeutic strategies
Authors: Sorrentino Zachary A. , Laurent Dimitri , Hernandez Jairo , Davidson Caroline , Small Coulter , Dodd William , Lucke‐Wold Brandon 
Published: September 2022

AbstractObjectiveThis narrative review of the literature concerns persistent headache attributed to past non‐traumatic subarachnoid hemorrhage (SAH), based off demographic and clinical features, what are pathophysiologic mechanisms by which these headaches occur, which medical and interventional treatments have the most evidence for pain alleviation, and what pre‐clinical evidence is there for emerging treatments for these patients.BackgroundFollowing initial stabilization and treatment of spontaneous SAH, most commonly due to aneurysmal rupture, headache in the immediate inpatient setting and persisting after discharge are an important cause of morbidity. These headaches often receive heterogenous treatment of uncertain efficacy, and the risk factors and pathophysiology of their development has received little study.MethodsA narrative review of current literature discussing post‐SAH headache was conducted using a literature search in PubMed with search term combinations including “post subarachnoid hemorrhage pain”, “subarachnoid hemorrhage headache”, and “post subarachnoid hemorrhage headache”. Clinical studies mentioning headache after SAH and/or treatment in the abstract/title were included through March, 2022.Results and ConclusionPost‐SAH headaches are shown to decrease quality of life, have a multi‐modal pathophysiology in their occurrence, and only a select few medications (reviewed herein) have been demonstrated to have efficacy in alleviation of these headaches, while also harboring possible risks including vasospasm and re‐bleeding. An effective treatment paradigm of these headaches will include trials of evidence‐based therapeutics, rapid reduction of opioid medications if not effective, and consideration of multi‐modal pain control strategies including nerve blocks.
Antibiotic resistance patterns of Helicobacter pylori in North Israel – A six‐year study
Authors: Azrad Maya , Vazana Dafna , On Avi , Paritski Maya , Rohana Hanan , Roshrosh Halim , Agay‐Shay Keren , Peretz Avi 
Published: September 2022

AbstractBackgroundOne main challenge in Helicobacter pylori (H. pylori) eradication is its increasing antibiotic resistance. Additionally, resistance rates vary between geographic areas and periods. However, data are limited since susceptibility testing is not routinely performed. Thus, it is valuable to gather data regarding H. pylori's resistance rates in Israel that would aid in better adjustment of treatment.Materials and MethodsThe study included 540 H. pylori isolates, recovered from gastric biopsy samples of patients who had undergone endoscopy, during 2015–2020, at the Padeh Poriya Medical Center. Antibiotic susceptibility testing to amoxicillin, clarithromycin, metronidazole, levofloxacin, rifampicin, and tetracycline was performed using the Etest technique. Data regarding participants' sex, age, and ethnic group were collected. For every antibiotic and for multi‐resistance, generalized linear models were used to estimate crude and adjusted estimated differences in mean MIC and odds ratios (ORs) for every year, compared with the reference year 2015.ResultsThe highest resistance rates were for clarithromycin and metronidazole (46.3% and 16.3%, respectively). Patients above 18 had higher resistance rate to rifampicin and multi‐resistance (3.3% and 14.8%), compared with patients under 18 (0.5% and 8.4%, respectively). Resistance rates for levofloxacin, rifampicin, and multi‐resistance were significantly higher among Arab patients, compared with Jewish patients. During the 6‐year surveillance, a significant annual trend in MIC for metronidazole and in ORs for metronidazole, levofloxacin, and multi‐resistance were observed (after adjustment). During 2020 compared with 2015, significant increased ORs were observed for levofloxacin and metronidazole [5.72 (1.03–31.84); 4.28 (1.30–14.14), respectively].ConclusionsIn light of the remarkable changes in antibiotic resistance of H. pylori during the study's period and the increasing resistance rates to various antibiotics, it is very important to continuously monitor H. pylori antibiotic susceptibly. In order to increase eradication rates of this bacterium, therapy regimes must be based on an updated antibiotic resistance data.
Avoiding glass spot defect arising from roller hydrogen embrittlement via regulating protective atmosphere distribution
Authors: Tong Lianjie , Wang Changjun , Zhang Qingshan , Li Wenfeng , Xu Shiqing , Liu Shimin 
Published: September 2022

AbstractA kind of float glass spot defect, characterized by small size, metallic luster, and difficult to clean, adheres only to the lower surface (contacts with molten tin) of the float glass ribbon. This defect causes serious production loss. Therefore, determining the precise source of this spot defect and the effective prevention of its occurrence is vital in the scientific interest and technological significance. Herein, we report a new idea for preventing glass spot defect resulting from roller hydrogen embrittlement (HE) via regulating protective atmosphere distribution. We also reveal its formation mechanism. The generation mechanism of this spot defect shows that the protective atmosphere in the tin bath diffuses into the annealing lehr. However, the annealing lehr does not effectively discharge it (particularly H2). Thus, roller HE occurs. Opening the vent decreases the H2 concentration around the roller. In addition, the vent is moved by ∼1 m in the original position toward the exit of the annealing lehr, which is most conducive to H2 discharge. This optimization measure reduces or eliminates the spot defect caused by the HE of the roller. Moreover, it has great application potential in the design of float glass annealing lehr.
Incorporating corporate social responsibility into graduate employability
Authors: Bisschoff Zelda S. , Massyn Liezel 
Published: September 2022

AbstractTo remain sustainably viable in today's business environment, employers require appropriate skills to support their commitment to social responsibility. When recruiting skills, employers recognize that graduate attributes are essential indicators of the capability to render constructive workplace outcomes. Graduates need to develop these attributes to demonstrate their employability potential to prospective employers. However, existing employability capital frameworks do not include the graduate attributes needed to measure capability in corporate social responsibility (CSR) skills. The objective of this study was to determine which graduate attributes would support employability capability in CSR skills. Following a theoretical investigation, a mixed‐method exploratory study was undertaken in South Africa's state‐owned electricity provider to determine the employability attributes required by the organization in CSR management. The first phase involved a data collection survey, 302 managers and supervisors in South Africa's primary electricity provider rated a proposed 44 personal attributes linked to nine theoretical determined CSR skills and their importance in CSR management. In the second phase, the survey results were validated through a separate Delphi technique with three Human Resource Development experts. Confirmatory factor analysis found significant relationships between the tested attributes and the nine CSR skills. The findings could assist graduates in understanding the attributes they need to develop to be deemed employable for CSR performance. Furthermore, higher education institutions can include the results in curriculums to contribute to the development of CSR skills. Finally, the attributes and skills could be used to conceptualize a focused CSR employability capital, which employers can use to test employability potential.
New descriptions of four larval lanternfish species and cryptic diversity ofBenthosema pterotum(Pisces: Myctophidae) from the Northwest Pacific
Authors: Lee Hye‐Lyang , Yu Hyo‐Jae , Kim Jin‐Koo 
Published: September 2022

AbstractAlthough there have been many studies on the taxonomy of lanternfishes, morphological similarities during larval and juvenile stages make it difficult to identify species and understand their early life histories. During an ichthyoplankton survey in the Northwest Pacific (East Sea, East China Sea) between 2017 and 2020, a research vessel from the National Institute of Fisheries Science collected larvae and juveniles that belonged to the family Myctophidae using a bongo net. To accurately identify species, mtDNA sequences encoding cytochrome c oxidase subunit I and 16S ribosomal RNA were obtained and compared with those of adult voucher specimens. These comparisons led to the identification of four previously unknown larval lanternfish species (Diaphus chrysorhynchus,Diaphus suborbitalis,Diaphus wataseiandLampanyctus fernae), which are described here for the first time. The authors also describe the cryptic diversity ofBenthosema pterotumand provide identification keys for 10 species of larval lanternfish, in accordance with their developmental stages.
Cerclage in surgically shortened uterine cervix and pregnancy outcome: A retrospective comparison between the abdominal and vaginal procedures
Authors: Akeno Keiko , Ohashi Masanao , Furukawa Seishi , Sameshima Hiroshi 
Published: September 2022

AbstractBackgroundCerclage for uterine cervical incompetence can be performed by the transabdominal or transvaginal approach. Transabdominal cerclage (TAC) is indicated for women with a short cervix or a cervical laceration who are inapplicable to transvaginal cerclage (TVC). The larger the volume of tissue removed in cervical conization, the greater the rate of miscarriage or preterm delivery in the subsequent pregnancy.AimsThe aim of this study was to compare TAC and TVC in post‐cervical conization pregnancies.MethodsA retrospective, two‐group, comparative study was conducted involving subjects who underwent cervical cerclage (TAC, n = 14; TVC, n = 18) following cervical conization and who were cared for at the University of Miyazaki Hospital between 2008 and 2020. We compared study subject characteristics and outcomes between the two groups. Primary outcome was incidence of preterm labor <37 weeks of gestation between the two groups.ResultsThe preoperative median cervical length was significantly shorter in the TAC group (20.0 mm) than in the TVC group (31.0 mm; p < 0.01). Preoperative vaginal discharge cultures positive for Gardnerella showed a tendency to be greater in the TAC group (p = 0.073). There was no significant difference in the preterm delivery rate < 37 weeks of gestation between TAC (1/14, 7.1%) and TVC (6/18, 33.3%) groups, p = 0.10. Noninferiority test using multiple regression analysis showed that TAC is not inferior to TVC regarding gestational age at delivery, even though cervical length of TAC was significantly shorter.ConclusionWomen who were inapplicable to TVC due to a short cervix still achieved an equivalent outcome with TAC.
Tensile bond strength of soft and hard relining materials to conventional and additively manufactured denture‐base materials
Authors: Koseoglu Merve , Tugut Faik , Akin Hakan 
Published: September 2022

AbstractPurposeStudies comparing tensile bond strength of various soft and hard denture liner materials to conventionally and additively manufactured denture base resins are lacking. The purpose of this study was to investigate the tensile bond strength between chair‐ and laboratory‐side soft and hard relining materials and denture‐base materials produced by additive manufacturing and conventional methods.Materials and methodsA total of 120 dimethacrylate‐based additively manufactured and polymethylmethacrylate (PMMA)‐based conventionally fabricated dumbbell‐shaped denture‐base resins were produced. Heat‐cured laboratory‐side soft reline material, self‐cured chair‐side soft reline material, and self‐cured chair‐side hard reline material were attached to the denture bases. The tensile force was applied to the specimens with a universal testing machine at a crosshead speed of 5 mm/min. The obtained data were analyzed with two‐way ANOVA and post hoc Tukey tests. The significance level was set at α = 0.05.ResultsThe highest tensile bond strength values were obtained in the specimens from the conventionally manufactured base and self‐cured chair‐side hard reline material group, and the lowest was seen in the additively fabricated base and self‐cured chair‐side soft reline material group (p < 0.001). Conventionally manufactured base material's tensile bond strength was higher than that of additively fabricated resin, and self‐cured chair‐side hard reline material's strength was higher than that of laboratory‐side and chair‐side soft reline materials (p < 0.001). However, no significant difference emerged between laboratory‐side and chair‐side soft reline materials (p = 0.405).ConclusionsAll the specimens used in the present study had tensile bonding stress values for clinical use. Both denture base resins provided an increased bond to the chair‐side hard relining material, although an improved bond did not emerge for the chair‐side and laboratory‐side soft denture reline materials.