bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication of highly electrically conductive polypropylene/polyolefin elastomer/multiwalled carbon nanotubes composites via constructing ordered conductive network assisted by die‐drawing process
Authors: Zhao Zhongguo , Zhou Shengtai , Ai Taotao , Li Yapeng , Yang Qi , Jia Shikui , Tang Dahang 
Published: July 2022

AbstractIn this work, a facile strategy is proposed to prepare highly electrically conductive polypropylene (PP)/polyolefin elastomer (POE)/multiwalled carbon nanotubes (MWCNTs) composites with ordered conductive networks using a house‐made die‐drawing apparatus. Results showed that increasing either die‐drawing speed or drawing ratio led to an increase of crystallinity by 10% and orientation factor by 0.15 for PP, respectively, which played an important role in tuning the electrical conductivity and mechanical properties. Prior to die‐drawing process, MWCNTs were selectively distributed in POE domains, resulting in a remarkable increase of electrical conductivity. The prevailing high‐stress field during die‐drawing process was able to deform MWCNTs‐enriched POE domains to ordered microfibrillar structure, as confirmed by morphology observations. This resulted in a further increase of electrical conductivity for die‐drawn PP/POE/MWCNTs composites when compared with that of MWCNTs‐containing counterparts without die‐drawing. Moreover, both the tensile strength and elongation at break for die‐drawn PPCNTE30 composites were increased by 20% and 127% as compared with their counterparts without die‐drawing treatment.
Rethinking the open access citation advantage: Evidence from the “reverse‐flipping” journals
Authors: Ming Wei , Zhao Zhenyue 
Published: July 2022

AbstractAlthough the open access citation advantage (OACA) has been discussed extensively, scholars lack a clear understanding of the mechanisms through which switching from subscription‐based model to open access (OA) model affects the citation impact of a scholarly journal. Many journals have switched from subscription to OA, yet they later also flipped their preswitching articles (i.e., those under subscription model) to OA, thus leaving no subscription article to be compared with their postswitching OA counterparts. To detect the switching effect, our study instead focused on 60 journals that “reverse flipped” from OA to subscription. We use a difference‐in‐difference (DiD) analytical framework to analyze two propositions related to OACA, based on the bibliographic and citation data of pre‐ and postswitching publications in these journals. Our findings indicate that reverse flipping is unlikely to affect the journals' impact through changing the visibility of their articles. Instead, it could lead to a systematical shift in the submissions to the journals and thus considerably affect their impact. Our findings have important theoretical and practical implications for subsequent studies, funding agencies, and scholarly journals considering a reverse flip.
Moisture sources tracking of a cold vortex rainstorm over Northeast China usingFLEXPART
Authors: Yang Yuting , Cui Xiaopeng , Zou Qiangli 
Published: July 2022

AbstractWater vapor sources and related transport processes are fundamental to the understanding of precipitation mechanisms. This study focuses on a typical Northeast Cold Vortex (NECV) rainstorm on July 25, 2016, which brought floods and huge economic losses to Northeast China. Using the Lagrangian flexible particle dispersion model (FLEXPART) and the areal source–receptor attribution method, the moisture sources and transport characteristics during this event were analyzed. The results show that this NECV rainstorm occurred under a favorable atmospheric circulation background, and particles in the rainstorm area mainly came from the Indo‐China Peninsula, South China Sea, Bay of Bengal, and central China at relatively low levels. The largest water vapor uptake and release were found in central China, which was the primary moisture source of this NECV precipitation. Although the Indian Subcontinent–Bay of Bengal–Indo‐China Peninsula had a higher moisture intake than the South China Sea–the Philippines, a considerable amount of moisture in the former was released during transport, making the moisture contributions of the two equivalents. Furthermore, the Northeast rainstorm area had a non‐negligible precipitation recycling process. All examined sources contributed more than 90% of the moisture in the rainstorm area.
Control of the oxidation state of copper in copper silicate SGU‐29 for efficient catalytic reduction
Authors: Yu Hyejin , Kim Hyun Sung 
Published: July 2022

AbstractIn transition metal‐based zeotype systems, engineering transition metal species through ion exchange, doping, and oxidation state control to achieve heterogeneous catalytic systems is considered an effective strategy to improve catalytic performance. Among these strategies, controlling the oxidation state of transition metal species is a promising method to enhance the catalytic properties. Herein, we demonstrate for the first time that zeotypes containing Cu(I) can be effectively generated through the reduction of Cu(II) to Cu(I) in [CuO4]2− in the SGU‐29 framework using a hydrogen/argon gas mixture. Our results showed that reduced SGU‐29 (rSGU‐29) exhibited a high catalytic performance while reducing 4‐nitrophenol, providing 99% conversion.
The protective mechanism of protein kinase R to inhibit neuronal ferroptosis in cerebral injury from subarachnoid hemorrhage
Authors: Lei Jianwei , Song Shuxin , Chen Zhihua , Shu Sihong , Liu Qiang , Hu Wei 
Published: July 2022

AbstractPurpose: To investigate the role and mechanism of protein kinase R (PKR) in subarachnoid hemorrhage (SAH)‐mediated ferroptosis.Methods: A rat SAH model was constructed and treated with PKR inhibitor C16 to observe SAH and neurological impairment in rats and to detect malonaldehyde (MDA), iron ions content, ferritin heavy polypeptide 1 (FTH1) and glutathione peroxidase 4 (GPX4), and other related ferroptosis indicators in brain tissue. RNA sequencing analysis was used to investigate the mechanism of PKR, affecting the ferroptosis network of SAH.Results: SAH caused severe fundic hemorrhage, neurological impairment, MDA and iron ion accumulation, and significant decrease in GPX4 and FTH1 levels in rats. C16 treatment significantly improved the above signs caused by SAH. By RNA‐seq analysis, brain tissue of SAH‐treated rats with SAH and C16 differentially expressed mRNA target genes enriched in stress response and organic developmental signaling pathways.Conclusion: Inhibition of PKR may improve cerebral injury after SAH by inhibiting ferroptosis, and RNA sequencing staged its mechanism of action may be related to the stress response.
Autologous stem cell transplantation (ASCT) for acute myeloid leukemia in patients in first complete remission after one versus two induction courses: A study from the ALWP of the EBMT
Authors: Nagler Arnon , Galimard Jacques‐Emmanuel , Labopin Myriam , Blaise Didier , Arcese William , Trisolini Silvia Maria , Wu Depei , Pigneux Arnaud , Van Gorkom Gwendolyn , Rubio Marie‐Thérèse , Gedde‐Dahl Tobias , Huynh Anne , Lanza Francesco , Gorin Norbert‐Claude , Mohty Mohamad 
Published: July 2022

AbstractBackgroundAchieving complete remission (CR) is the main goal in AML treatment and a prerequisite for successful autologous stem cell transplantation (ACT).MethodsComparing results of peripheral blood ACT in patients with AML in CR1 attained following 1 versus 2 chemotherapy courses transplanted in 2000–2019.ResultsPatients 1532 (84%) with one and 293 (16%) patients with two induction chemotherapies courses (a total of 1825 patients) were included in the study. Follow‐up was 7.9 (95% CI: 7.4–8.4) and 7.7 (95% CI: 7.0–8.6) years (p = 0.8). Time from diagnosis to ACT was 4.7 (range, 3.9–5.8) versus 5.7 (range, 4.7–7.1) months (p < 0.001), respectively.Leukemia free survival (LFS) and overall survival (OS) at 5 years were inferior for patients achieving CR1 with 2 versus 1 course of chemotherapy: 26.6% versus 41.7% (HR = 1.42 [95% CI: 1.22–1.66], p < 0.001) and 36.2% versus 53.3%, (HR = 1.48 [95% CI: 1.25–1.75], p < 0.001), and 5‐year relapse incidence (RI) was higher: 67.2% versus 52.3%, (HR = 1.46 [95% CI: 1.25–1.72], p < 0.001). Five‐year non‐relapse mortality (NRM) was 6.2% versus 6.0% for patients with 2 versus 1 chemotherapy courses, and did not differ significantly (HR = 1.31 [95% CI: 0.81–2.10], p = 0.27).ConclusionsLFS and OS were inferior and relapse rate was higher in AML patients who received two inductions chemotherapy courses to reach CR1 before being autografted. AML patients who required 2 induction courses to achieve remission, may be offered allogeneic transplantation rather than an autologous one in an attempt to reduce their high RI and improve outcomes.
Iatrogenic cold urticaria induced by tetrafluoroethane cryosurgery for gingival depigmentation: A rare case report
Authors: Muthuraj Thamil Selvan , Sarkar Puja , Renganath Murugan Jeyasree , Senthilkumaran Pillaiyar Gurusamy 
Published: July 2022

AbstractIntroductionGingival depigmentation procedure has gained widespread popularity in the recent years due to increased esthetic demands among patients. Among the various depigmentation procedures, cryosurgery is inexpensive and straightforward method. This case report discusses a rare complication associated with tetrafluoroethane (TFE) cryosurgical depigmentation method.Case PresentationA 27‐year‐old systemically healthy male patient reported with the complaint of esthetic concerns associated with gingival melanin pigmentation. Cryosurgery with TFE was planned for the maxillary first quadrant. The patient developed angioedema immediately after exposure to the TFE cryogen during the procedure. Cold urticaria was considered, and the patient was prescribed nonsedating antihistamines for a week. One month follow‐up showed completely healed and depigmented gingiva without any recession or attachment loss.ConclusionsTFE cryosurgery depigmentation was found to be an effective depigmentation procedure. However, various complications including cold urticaria have been associated with its application. Therefore, the procedure's success depends on the proper case selection, complete isolation of the operating area, and preoperative test for gingival tissue response.Key pointsWhy is this case new information?

Cold urticaria formation after applying cryosurgery has never been reported in the literature to the best of the authors' knowledge.
What are the keys to the successful management of this case?

Preoperative testing for tissue response to cryosurgery will prevent complications like cold urticaria.
What are the primary limitations to success in this case?

Improper medical history and not taking tissue response test for cryosurgery.
Collodion phenotype remains a challenge for neonatologists: A rare case of self‐healing collodion baby
Authors: Zdraveska Nikolina , Kostovski Aco , Sofijanova Aspazija , Jancevska Snezana , Damevska Katerina 
Published: July 2022

AbstractWe report a unique case of self‐healing collodion baby (CB) that was successfully managed despite the risk of potentially serious complications. Self‐healing CB is a rare and distinct outcome of collodion phenotype occurring in approximately 10% of the cases. The outcome depends on the initial assessment and adequate multidisciplinary approach.
Advances and challenges in the pharmacokinetics and bioanalysis of chiral drugs
Authors: Kumari Rayala V. V. S. Prasanna , Kandula Jony Susanna , P Radhakrishnanand 
Published: July 2022

AbstractEnantioselective analytical approaches are essential for monitoring pharmacokinetics and acquiring accurate data to better understand the role of stereochemistry in pharmacokinetics. Enantioselectivity significantly impacts the pharmacokinetics of chiral drugs, especially in metabolic profile, leading to toxicity of enantiomer. Consequently, there is a need to study the pharmacokinetics of enantiomerically pure drugs and racemates as they differ in affinity with enzymes and proteins. Combining the best enantioseparation conditions with the specified biological matrix and the intended purpose of the analysis is a challenging task. This review discusses the importance of chirality in stereoselective pharmacokinetics with more relevant examples, various enantioselective analytical techniques, and stationary phases employed. Challenges such as lack of universal chiral columns, biological inversion of the isomers, and others have been discussed. Further presented the recent advances in the screening of chiral drugs and innovative improvements in the analytical approaches for chiral molecule analysis such as supercritical fluid chromatography, simulated moving bed chromatography, and other techniques are discussed.
Effective drag on spheres immersed in a fluidized bed at minimum fluidization—Influence of bulk solids properties
Authors: Guío‐Pérez Diana Carolina , Köhler Anna , Prati Anna , Pallarès David , Johnsson Filip 
Published: July 2022

AbstractThe aims of this work are to elucidate the effects that bulk solids properties have on the effective drag experienced by large spheres immersed in an emulsion of group‐B solids under minimum fluidization conditions and to analyze the ways in which the different suspensions react towards different applied shear rates. To investigate this, magnetic particle tracking was applied to resolve the trajectory of falling‐sphere measurements in which the size, density, and sphericity of the bulk solids were varied as well as the size and density of the spherical tracers. The resulting experimental scope included both rising and sinking tracers as well as full segregation and in‐bed stagnation of the tracers. The set‐up provided highly resolved tracer trajectories, from which the drag experienced by the sphere can be calculated. For sinking tracers, the results showed that an increase in bulk solids size, angularity, and density reduced the terminal velocity of the sphere. This effect correlated well with the bed expansion and Hausner ratio, indicating that a reduced void space among the bulk solids is the main reason for the increase in motion resistance. At lower shear rates, namely, during the de‐acceleration towards the stagnant state, beds of larger, more angular, or denser bulk solids yield lower levels of shear stress. The angle of repose of the bulk solids correlated with the rate at which the emulsion thins with increasing shear rate. For rising tracers, shear stress did not show any significant dependency on the properties of the bulk solids.
Does concomitant ductal carcinoma in situ affect the clinical outcome in breast cancer patients with invasive ductal carcinoma: An Asian perspective
Authors: Lee Wai Peng , Shetty Spoorthi Sudhakar , Seah Chin Mui Jaime , Tan Pei Ting , Tan Su Ming 
Published: July 2022

AbstractBackgroundDuctal carcinoma in situ (DCIS) is an established precursor to invasive ductal carcinoma (IDC) and its coexistence with IDC appear to favor reduced biological aggressiveness. Its prognostic implication and ability to affect clinical outcome has been understudied in Asia. This study aims to explore if concomitant DCIS affects the clinical behavior and outcomes among Asians.AimStages I to III breast cancer patients with histological proven IDC, diagnosed and treated in a single institution from June 1, 2004 to June 30, 2014 were included in this study. Statistical analyses were conducted using Χ2 test, independent t test, multivariate logistic regression and Kaplan–Meier test.Methods and ResultsA total of 818 patients were identified, including 224 and 594 patients with isolated IDC (No‐DCIS) and IDC with coexisting DCIS (IDC‐DCIS) respectively. Patients with IDC‐DCIS were found to have smaller tumors (median: 22 mm, p ≤ .01), estrogen receptor positivity (p = .001), progesterone receptor positivity (p < .001) and associated with better pathological stage (p = .001). Patients with No‐DCIS were 1.6 times more likely to develop disease progression (95% CI: 1.1–2.3, p = .027) and subsequently associated with distant recurrences (20.5% vs. 13.6%, p = .02). The breast cancer specific 5 year overall survival rate for patients with No‐DCIS and those with IDC‐DCIS was 90.9% (95% CI: 86.2%–94.5%) and 93.7% (95% CI: 91.4%–95.5%), respectively (p = .202).ConclusionThe presence of DCIS component in IDC among Asians is associated with favorable tumor biological profile, thereby indicating reduced disease aggressiveness. Our study is the first to report the clinical significance in terms of disease progression and distant recurrences among Asians.
Efficient Throttled load balancing algorithm to improve the response time and processing time in data center
Authors: B Ramana Reddy , M Indiramma 
Published: July 2022

SummaryIn today's world, cloud computing is an emerging service, and it has proved to be a profit‐oriented business model. A drastic growth was observed in cloud computing during the last decade because of its easy access to services. As the number of users are increasing dynamically, load balancing is required to handle the user's load. Load balancing algorithms minimize the data center processing time and increase the throughput. Therefore cloud service providers need the best dynamic strategies. In this work, the proposed Efficient Throttled load balancing algorithm improves the performance in the data center environment. Our experimental results indicate that the Efficient Throttled load balancing algorithm improves the average overall response time by 6.47% and average data center processing time by 20.74%, compared to the Throttled load balancing algorithm.
An experimental comparison of the widely used pre‐trained deep neural networks for image classification tasks towards revealing the promise of transfer‐learning
Authors: Kabakus Abdullah Talha , Erdogmus Pakize 
Published: July 2022

SummaryThe easiest way to propose a solution based on deep neural networks is using the pre‐trained models through the transfer‐learning technique. Deep learning platforms provide various pre‐trained deep neural networks that can be easily applied for image classification tasks. So, “Which pre‐trained model provides the best performance for image classification tasks?” is a question that instinctively comes to mind and should be shed light on by the research community. To this end, we propose an experimental comparison of the six popular pre‐trained deep neural networks, namely, (i) VGG19, (ii) ResNet50, (iii) DenseNet201, (iv) MobileNetV2, (v) InceptionV3, and (vi) Xception by employing them through the transfer‐learning technique. Then, the proposed benchmark models were both trained and evaluated under the same configurations on two gold‐standard datasets, namely, (i) CIFAR‐10 and (ii) Stanford Dogs to benchmark them. Three evaluation metrics were employed to measure performance differences between the employed pre‐trained models as follows: (i) Accuracy, (ii) training duration, and (iii) inference time. The key findings that were obtained through the conducted a wide variety of experiments were discussed.
Early‐like differentiation status of systemic PD‐1+CD8+ T cells predicts PD‐1 blockade outcome in non‐small cell lung cancer
Authors: Khanniche Asma , Yang Yi , Zhang Jie , Liu Shiqing , Xia Liliang , Duan Huangqi , Yao Yaxian , Zhao Bingrong , Zhao Guo‐Ping , Hu Chengping , Wang Ying , Lu Shun 
Published: July 2022

AbstractObjectivesDespite remarkable advances in the treatment of non‐small cell lung cancer (NSCLC) with anti‐programmed death (PD)‐1 therapy; only a fraction of patients derives durable clinical benefit. In this study, we investigated whether the differentiation status of systemic CD8+ T cells predicts the outcome of PD‐1 blockade in NSCLC.MethodsWe carried out a prospective study on a total of 77 NSCLC patients receiving anti‐PD‐1 blockers, among which 47 patients were assigned as a discovery cohort and 30 patients as a validation cohort. Peripheral blood samples were obtained at baseline and upon multiple therapy cycles and analyzed by multi‐parameter flow cytometry.ResultsWe found that a higher baseline ratio of PD‐1+ early effector memory CD8+ T cells (CD28+CD27−CD45RO+, TEEM) to PD‐1+ effector CD8+ T cells (CD28−CD27−CD45RO−, TE) delineated responders to PD‐1 blockade from progressors and was associated with prolonged progression‐free survival (PFS) and durable clinical benefit. Moreover, PD‐1+CD8 TEEM cells exhibited early responses after anti‐PD‐1 therapy and was the major fraction of cycling PD‐1+Ki67+CD8+ T cells to expand specifically with positive impact on PFS.ConclusionThese findings provide insights into how the baseline differentiation status of the peripheral immune system determines responses to PD‐1‐targeted therapies.
Spatial variability and uncertainty of soil nitrogen across the conterminous United States at different depths
Authors: Smith Elizabeth M. , Vargas Rodrigo , Guevara Mario , Tarin Tonantzin , Pouyat Richard V. 
Published: July 2022

AbstractSoil nitrogen (N) is an important driver of plant productivity and ecosystem functioning; consequently, it is critical to understand its spatial variability from local‐to‐global scales. Here, we provide a quantitative assessment of the three‐dimensional spatial distribution of soil N across the United States (CONUS) using a digital soil mapping approach. We used a random forest‐regression kriging algorithm to predict soil N concentrations and associated uncertainty across six soil depths (0–5, 5–15, 15–30, 30–60, 60–100, and 100–200 cm) at 5‐km spatial grids. Across CONUS, there is a strong spatial dependence of soil N, where soil N concentrations decrease but uncertainty increases with soil depth. Soil N was higher in Pacific Northwest, Northeast, and Great Lakes National Ecological Observatory Network (NEON) ecoclimatic domains. Model uncertainty was higher in Atlantic Neotropical, Southern Rockies/Colorado Plateau, and Southeast NEON domains. We also compared our soil N predictions with satellite‐derived gross primary production and forest biomass from the National Biomass and Carbon Dataset. Finally, we used uncertainty information to propose optimized locations for designing future soil surveys and found that the Atlantic Neotropical, Pacific Northwest, Pacific Southwest, and Appalachian/Cumberland Plateau NEON domains may require larger survey efforts. We highlight the need to increase knowledge of biophysical factors regulating soil processes at deeper depths to better characterize the three‐dimensional space of soils. Our results provide a national benchmark regarding the spatial variability and uncertainty of soil N and reveal areas in need of a better representation.
Use of metal nanoparticles for preconcentration and analysis of biological thiols
Authors: Itterheimová Petra , Dosedělová Věra , Kubáň Petr 
Published: July 2022

AbstractMetal nanoparticles (NPs) exhibit several unique physicochemical properties, including redox activity, surface plasmon resonance, ability to quench fluorescence, biocompatibility, or a high surface‐to‐volume ratio. They are being increasingly used in analysis and preconcentration of thiol containing compounds, because they are able to spontaneously form a stable Au/Ag/Cu–S dative bond. They thus find wide application in environmental and particularly in medical science, especially in the analysis of biological thiols, the endogenous compounds that play a significant role in many biological systems. In this review article, we provide an overview of various types of NPs that have been applied in analysis and preconcentration of biological thiols, mainly in human biological fluids. We first discuss shortly the types of NPs and their synthesis, properties, and their ability to interact with thiol compounds. Then we outline the sample preconcentration and analysis methods that were used for this purpose with special emphasis on optical, electrochemical, and separation techniques.