bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy of PD‐1 inhibitors in patients with salivary gland carcinoma: A retrospective observational study
Authors: Sato Ryosuke , Kumai Takumi , Ishida Yoshiya , Yuasa Ryota , Kubota Akinobu , Wakisaka Risa , Komatsuda Hiroki , Yamaki Hidekiyo , Wada Tetsuji , Harabuchi Yasuaki 
Published: November 2022

AbstractObjectiveImmune checkpoint inhibitors (ICIs) have been considered as novel therapeutic approaches for various cancers. ICIs were reportedly efficacious against rare cancers, including salivary gland carcinoma (SGC). We aimed to analyze the efficacy and safety of ICIs in patients with SGC.MethodsWe retrospectively analyzed the oncologic outcomes and immune‐related adverse events (irAEs) in patients with SGC treated with at least one cycle of nivolumab or pembrolizumab.ResultsAmong 12 patients, there were two with a complete response (CR), two with a partial response, five with stable diseases, and three with progressive diseases. The overall response rate was 33.3%. A CR was achieved in patients with poorly differentiated carcinoma (carcinoma ex pleomorphic adenoma) and salivary duct carcinoma. The progression‐free survival ranged between 1 and 18 months (median, 4 months), while the overall survival ranged between 2 and 25 months (median, 13.5 months). An irAE was observed in only one patient who developed grade 3 erythema multiforme, and this patient's condition improved with withdrawal of pembrolizumab alone.ConclusionProgrammed death‐1 blockade was an effective therapy for patients with SGC, including aggressive histologic types.
Correlations between objective and subjective outcomes after adenotonsillar surgery in children with OSA
Authors: Sjölander Isabella , Borgström Anna , Nerfeldt Pia , Fehrm Johan , Friberg Danielle 
Published: November 2022

AbstractObjectivesTo investigate whether the OSA‐18 questionnaire and a postoperative patient‐reported outcome measure (PROM) question correlated with polysomnography (PSG) data.MethodsA prospective study of otherwise healthy young children with moderate to severe obstructive sleep apnea (OSA) to investigate if the obstructive apnea–hypopnea index (OAHI) before and 6–12 months after adenotonsil surgery correlated with the OSA‐18 total symptom score (TSS) and the sleep disturbance subscale (SDS), as well as a PROM question on symptom improvement with responses on a 4‐grade Likert scale.ResultsOf 201 children, 173 (86%) had complete data of OAHI and OSA‐18 pre‐ and postoperatively. The mean age was 3.2 years (SD 1.0) and the mean OAHI was 15.9 (11.3). Significant correlations between changes in the OAHI and OSA‐18 were found, both TSS (r = 0.29, p < .001) and SDS (r = 0.53, p < .001). A total of 136 (68%) patients responded to the PROM question, the majority of whose symptoms had disappeared (n = 102) or almost disappeared (n = 30). Four patients had unchanged symptoms, and none had worsening symptoms. A correlation was found between the PROM question and a change in the OAHI (r = 0.36, p < .001), as well as a change in the OSA‐18 TSS (r = 0.24, p = .006) and the SDS (r = 0.34, p < .001). The specificity of the PROM question for prediction of a postoperative OAHI < 2 was 82%, and the sensitivity was 38%.ConclusionChanges in the OAHI significantly correlated with changes in the OSA‐18, especially with the sleep disturbance scale, which could be an alternative for evaluation at follow‐ups.Level of Evidence3
Photoinduced Side‐Chain Functionalization, Grafting, Cross‐Linking, and Chain Extension by Thiol‐Epoxide Click Reaction Using Photo Base Generator
Authors: Kiliclar Huseyin Cem , Yilmaz Gorkem , Li Zhiquan , Zheng Yuanjian , Yagci Yusuf 
Published: November 2022

AbstractIn this work, photoinduced thiol‐epoxy click reaction for side‐chain functionalization, chain‐extension, grafting, and cross‐linking of polymers prepared by atom transfer radical polymerization by using 1,5‐diazabicyclo[5.4.0]undec‐5‐ene thioxanthone acetate (Tx‐DBU) as a photo base generator (PBG) is described. Irradiation of Tx‐DBU at 365 nm leads to the generation of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) in neutral form as a super base. DBU is capable of abstracting protons from thiols and thus formed thiolates are excellent nucleophiles that exhibit high affinity toward electrophiles such as epoxide rings. Appropriately selected thiols are successfully used for the desired reactions. The precursors and resulting polymers are characterized using 1H‐NMR, Fourier transform infrared, gel permeation chromatography, and differential scanning calorimetry measurements. This study shows that the use PBGs can further be extended to the synthesis of various complex macromolecular structures by the described post modification processes.
Shore hardness behavior of light‐cured dental composite resin filled with TiO2 nanoparticles
Authors: A. A. Meshref 
Published: November 2022

AbstractIn this study, the influence of light curing times, curing modes and concentrations of titanium dioxide nanoparticles on the Shore hardness number of top and bottom surfaces and hardness ratio of hybrid composite resin is investigated. Hybrid composite resin and titanium dioxide nanoparticles are the materials used in this study. Titanium dioxide nanoparticles are added to hybrid composite resin. The resulting paste is placed in plastic bars and cured using a visible light curing unit for 60 s, 80 s, 100 s and 120 s from both sides. The curing modes used are gradually strong, flashing and strong modes. Hardness number of top and bottom surfaces is measured using Shore D durometer test. The results show that the curing times, curing modes and concentrations of titanium dioxide nanoparticles have influence on the Shore hardness numbers. The Shore hardness numbers at 120 s is higher than that obtained for a 60 s cure time and flashing curing mode produce dental nanocomposite resin with higher Shore hardness numbers. The Shore hardness numbers of the studied hybrid composite is increased by adding 0.5 wt.% and 0.6 wt.% of titanium dioxide nanoparticles.
Impact of additive thermal loads on the long‐term behaviour of current‐carrying bolted joints made of tinned and nickel‐plated aluminum and copper conductor materials in electrical vehicle
Authors: Poudeu F.S.D. , Beilner M. , Schlegel S. 
Published: November 2022

AbstractZur Stromübertragung innerhalb von elektrischen Komponenten (zum Beispiel in der Batterie) im Fahrzeug werden bevorzugt Stromschienen eingesetzt. Diese werden aus Gründen der Austauschbarkeit und Reparaturfähigkeit über Schraubenverbindungen gefügt. Abhängig von den Leiter‐ und den Beschichtungswerkstoffen, den Montageparametern und den Belastungsbedingungen im Betrieb altern diese stromführenden Schraubenverbindungen zeitabhängig. Dadurch erhöhen sich der Verbindungswiderstand und die Verbindungstemperatur. Wenn die anwendungsspezifische Grenztemperatur an der Kontaktstelle erreicht ist, kann die Funktion der Schraubenverbindung beeinträchtigt werden oder ein Ausfall auftreten. In diesem Beitrag werden die Einflüsse der Belastungsarten abhängig von den Leiter‐ und Beschichtungswerkstoffen und von der Montagevorspannkraft auf das Verhalten von Schraubenverbindungen untersucht und gegenüber dargestellt. Darauf aufbauend wird die dominante Belastung hergeleitet.
Effect of welding material on microstructure and properties of welded joints of bridge weathering steel Q345qDNH
Authors: Guo T. , Dong Z. , Nan X. , Liu X. , Zhang L. 
Published: November 2022

AbstractThe matching between the wire material and the base metal has an extremely important influence on the performance of the welded joint. In this work, the effects of two welding materials THQ440‐NQ‐II and ER50‐6 with different compositions on the microstructure, mechanical properties and corrosion resistance of bridge weathering steel Q345qDNH were investigated. Although the mechanical properties of the two welded joints are lower than those of the base metal, the yield strength, elongation after fracture, impact toughness at 20 °C and −40 °C of THQ440‐NQ‐II welded joints are 6.8 %, 23.5 %, 13.7 %, 18 % higher than those of ER50‐6 welds, respectively. THQ440‐NQ‐II welds are ductile fractures and quasi‐cleavage fractures at 20 °C and −40 °C, respectively; while ER50‐6 welds are quasi‐cleavage fracture and cleavage fracture at 20 °C and −40 °C, respectively, the ductile‐brittle transition temperature of ER50‐6 weld is higher than that of THQ440‐NQ‐II weld. Comparing the corrosion resistance in 3.5 % sodium chloride (NaCl) solution, THQ440‐NQ‐II weld is better than the base metal, while ER50‐6 welds are lower than the base metal. This is because the nickel, chromium, copper elements contained in the THQ440‐NQ‐II welding wire can inhibit the formation of Widmanstätten structure and upper bainite during the welding process, refine the structure, increase the content of acicular ferrite, and reduce the ductile‐brittle transition temperature of welding joint, improves the corrosion resistance of the weld.
Auctions versus posted prices in the revenue management of limited inventory
Authors: Maslov Alexander 
Published: November 2022

AbstractThe paper examines a monopolistic seller with a limited inventory, who can sell it by auctions or posted prices in an online market. Previous studies have investigated a seller with unlimited inventory and found that selling by auctions and posted prices is the profit‐maximizing strategy. Contrary to this finding, for limited inventory, mixing selling mechanisms is not always optimal. In particular, when the number of risk‐neutral buyers is high, listing the inventory by auctions generates the highest profit. When faced with risk‐averse buyers, selling by posted prices and auctions is the best strategy. Posted prices are almost always inferior to other listing strategies.
Recent advances in the liquid‐phase 6,7Li nuclear magnetic resonance
Authors: Krivdin Leonid B. 
Published: November 2022

AbstractThe present review is focused on experimental methods and structural applications, including computational aspects, of classical lithium liquid‐phase nuclear magnetic resonance (NMR). It consists of four parts covering accordingly a brief overview, early experimental reports (papers of up to about 2015) and more recent (papers appearing in the interim of about 2015 until 2022) results, together with very few but highly prospective computational results.
Improving the ductility, toughness, and electrical conductivity of poly(lactic acid) by forming poly(lactic acid)/thermoplastic polyester elastomer blend and blend‐based nanocomposites
Authors: Jen Ting‐Ni , Behera Kartik , Chang Yen‐Hsiang , Chiu Fang‐Chyou 
Published: November 2022

AbstractIn this study, poly(lactic acid) (PLA)/thermoplastic polyester elastomer (TPEE) (70/30) blend and blend‐based nanocomposites with carbon nanotube (CNT) as a nanofiller were fabricated by conventional melt mixing. Scanning electron microscopy results showed that the blend had a biphasic morphology, and CNTs were selectively distributed in the dispersed TPEE domains in the composites. The presence of CNTs induced the agglomeration and shape modification of TPEE domains, consequently influencing the examined properties. Differential scanning calorimetry results revealed that the crystallizability of PLA was improved after blending with TPEE, and further CNT incorporation increased the crystallization temperature of TPEE during cooling. The elongation at break (EB) and notched impact strength (IS) of PLA were evidently improved in the blend and composites. In particular, the EB and IS in the composites increased by up to 290% and 43%, respectively. The electrical resistivity of neat components and the blend decreased by up to eight orders of magnitude after 3 phr CNT loading due to double percolation in TPEE domains and dispersed CNTs. A percolation threshold at ca. 1 phr CNT loading for electrical conductivity was determined. Rheological property analysis suggested the formation of a pseudo‐network structure, which was attributed to the CNTs increasing the viscosity of the TPEE domains in the composites.
A new analytic tool for assessing the impact of the US Food and Drug Administration regulatory actions
Authors: Lu Christine Y. , Hou Laura , Kolonoski Joy , Petrone Andrew B. , Zhang Fang , Corey Catherine , Huang Ting‐Ying , Bradley Marie C. 
Published: November 2022

AbstractPurposeDevelop and test a flexible, scalable tool using interrupted time series (ITS) analysis to assess the impact of Food and Drug Administration (FDA) regulatory actions on drug use.MethodsWe applied the tool in the Sentinel Distributed Database to assess the impact of FDA's 2010 drug safety communications (DSC) concerning the safety of long‐acting beta2‐agonists (LABA) in adult asthma patients. We evaluated changes in LABA use by measuring the initiation of LABA alone and concomitant use of LABA and asthma controller medications (ACM) after the DSCs. The tool generated ITS graphs and used segmented regression to estimate baseline slope, level change, slope change, and absolute and relative changes at up to two user‐specified time point (s) after the intervention. We tested the tool and compared our results against prior analyses that used similar measures.ResultsInitiation of LABA alone declined among asthma patients aged 18–45 years before FDA DSCs (−0.10% per quarter; 95%CI: −0.11% to −0.09%) and the downward trend continued after. Concomitant use of LABA and ACM was stable before FDA DSCs. After FDA DSCs, there was a small trend decrease of 0.006% per quarter (95% CI, −0.008% to −0.003%). We found similar results among those aged 46–64 years and patients with poorly‐controlled asthma. Our results were consistent with previous studies, confirming the performance of the new tool.ConclusionsWe developed and tested a reusable ITS tool in real‐world databases formatted to the Sentinel Common Data Model that can assess the impact of regulatory actions on drug use.
Rituximab pharmacokinetic and pharmacokinetic–pharmacodynamic evaluation based on a study in diffuse large B‐cell lymphoma: Influence of tumor size on pharmacokinetic and assessment of pharmacokinetic similarity
Authors: Svensson Robin J. , Ooi Qing Xi , Friberg Lena E. , Maharaj Narendra , Reddy Pramod Kumar , López‐Lázaro Luis , Hansson Emma 
Published: November 2022

AbstractDr. Reddy's Laboratories rituximab (DRL_RI; Dr. Reddy's Laboratories SA, Basel, Switzerland) is under development as a rituximab biosimilar. Study RI‐01‐002 (Clinical Trials Registry ‐ India/2012/11/003129), comparing DRL_RI to the reference medicinal product (RMP) MabThera® (Roche, Grenzach‐Wyhlen, Germany), demonstrated pharmacokinetic (PK) equivalence and showed comparable pharmacodynamic, efficacy, safety, and immunogenicity profiles. We used data from the same study to perform population PK and PK–pharmacodynamic analyses: first exploring possible factors influencing the PK similarity assessment between products and then performing simulations to investigate the impact of tumor size on rituximab PK. Nonlinear mixed‐effects models for PK, tumor size, tumor size–PK, and tumor response were developed independently. The final PK model included drug product as a dose‐scaling parameter and predicted a 6.75% higher dose reaching the system in RMP‐treated patients. However, when tumor size was included in the tumor size–PK model, the drug product effect was no longer observed. The model rather indicated that patients with larger tumor size have higher clearance. Further simulations confirmed that higher baseline tumor size is associated to slightly lower rituximab exposure. Tumor response, described by a continuous‐time Markov model, did not differ between drug products. Both had higher effects during the first 20 weeks of treatment. Also, the model described a subpopulation of nonresponders to treatment (42%) with faster transitions to a worse state. The different rituximab exposure initially detected between drug products (6.75%) was shown using PK/PK–pharmacodynamic analysis to be attributed to a tumor size imbalance between treatment groups. PK/PK–pharmacodynamic analyses may contribute to PK similarity assessments.
The effect of almond intake on cardiometabolic risk factors, inflammatory markers, and liver enzymes: A systematic review and meta‐analysis
Authors: Morvaridzadeh Mojgan , Qorbani Mostafa , Shokati Eshkiki Zahra , Estêvão M. Dulce , Mohammadi Ganjaroudi Negar , Toupchian Omid , Abdollahi Shima , Pizarro Ana Beatriz , Abu‐Zaid Ahmed , Zadro Joshua R. , Heshmati Javad , Ziaei Somayeh 
Published: November 2022

AbstractAlmond intake may be correlated with improvements in several cardiometabolic parameters, but its effects are controversial in the published literature, and it needs to be comprehensively summarized. We conducted a systematic search in several international electronic databases, including MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov until April 2021 to identify randomized controlled trials that examined the effects of almond consumption on cardiometabolic risk factors, inflammatory markers, and liver enzymes. Data were pooled using the random‐effects model method and presented as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Twenty‐six eligible trials were analyzed (n = 1750 participants). Almond intake significantly decreased diastolic blood pressure, total cholesterol, triglyceride, low‐density lipoprotein (LDL), non‐high‐density lipoprotein (HDL), and very LDL (p < 0.05). The effects of almond intake on systolic blood pressure, fasting blood glucose, insulin, hemoglobin A1c, homeostatic model assessment of insulin resistance, C‐peptide, alanine aminotransferase, aspartate aminotransferase, gamma‐glutamyl transferase, C‐reactive protein (CRP), hs‐CRP (high sensitivity C‐reactive protein), interleukin 6, tumor necrosis factor‐α, ICAM (Intercellular Adhesion Molecule), VCAM (Vascular Cell Adhesion Molecule), homocysteine, HDL, ox‐LDL, ApoA1, ApoB, and lipoprotien‐a were not statistically significant (p > .05). The current body of evidence supports the ingestion of almonds for their beneficial lipid‐lowering and antihypertensive effects. However, the effects of almonds on antiinflammatory markers, glycemic control, and hepatic enzymes should be further evaluated via performing more extensive randomized trials.
Targeted Additive Micromodulation of Grain Size in Nanocrystalline Copper Nanostructures by Electrohydrodynamic Redox 3D Printing
Authors: Menétrey Maxence , Koch Lukas , Sologubenko Alla , Gerstl Stephan , Spolenak Ralph , Reiser Alain 
Published: November 2022

AbstractThe control of materials’ microstructure is both a necessity and an opportunity for micro/nanometer‐scale additive manufacturing technologies. On the one hand, optimization of purity and defect density of printed metals is a prerequisite for their application in microfabrication. On the other hand, the additive approach to materials deposition with highest spatial resolution offers unique opportunities for the fabrication of materials with complex, 3D graded composition or microstructure. As a first step toward both—optimization of properties and site‐specific tuning of microstructure—an overview of the wide range of microstructure accessed in pure copper (up to >99.9 at.%) by electrohydrodynamic redox 3D printing is presented, and on‐the‐fly modulation of grain size in copper with smallest segments ≈400 nm in length is shown. Control of microstructure and materials properties by in situ adjustment of the printing voltage is demonstrated by variation of grain size by one order of magnitude and corresponding compression strength by a factor of two. Based on transmission electron microscopy and atom probe tomography, it is suggested that the small grain size is a direct consequence of intermittent solvent drying at the growth interface at low printing voltages, while larger grains are enabled by the permanent presence of solvent at higher potentials.
The effect of spouses' relative education on household time allocation
Authors: Taveras Elisa 
Published: November 2022

AbstractDoes spouses' relative education explain their household's distribution of labor? This paper analyzes the effect of spouses' education on time allocated to housework and paid work. To address endogeneity concerns, I exploit changes in spouses' relative education due to remarriage to identify its effects on their time allocation. I find that when a husband marries a wife with a higher relative education than their previous spouse, his share of time on housework increases while his share of time on paid work decreases. In contrast, I find nonsignificant results when a wife remarries a more educated husband than her previous one. I also find that changes in the spouse's education reduce the probability of a spouse staying at home. These findings show that relative human capital plays a role in household labor distribution and motivates a more gender‐neutral division of labor within households due to a more evenly distributed time allocation.
Make‐up gas influence on the signal behavior of the Vacuum ultraviolet detector for gas chromatography
Authors: Lelevic Aleksandra , Geantet Christophe , Lorentz Chantal , Moreaud Maxime , Souchon Vincent 
Published: November 2022

AbstractA vacuum ultraviolet absorbance detector features the addition of the make‐up gas whose purpose is to decrease the diffusion of analytes in the flow cell. It has been previously demonstrated that the vacuum ultraviolet detector VGA 100 is a concentration‐sensitive detector for which the signal area is inversely proportional to the total flow in the flow cell. In this work, the signal behavior in the new generation vacuum ultraviolet detector, which features changed configuration for the introduction of make‐up gas, was explored. Contrary to previous instruments, a non‐linear relationship between the detector signal area and the inverse of the total flow in the flow cell (carrier gas flow + make‐up gas flow) was observed. To explain these observations, we have investigated the behavior of the detector in combination with one‐dimensional and two‐dimensional gas chromatography. Based on the results obtained, it was concluded that in these next‐generation instruments, flow in the flow cell cannot be regarded as a simple sum of the gas chromatography column flow and the total make‐up flow. After making modifications to the estimation of the total effective flow in the flow cell, a linear relationship between the signal area and the inverse of the flow in the flow cell was recovered.
Pareto chart‐enabled screening of influential factors in designing transfersomes
Authors: Modi Chetna , Bharadia Praful 
Published: November 2022

AbstractMethotrexate is the treatment of choice for rheumatoid arthritis, having significant side effects on oral administration, prompting researchers to consider transdermal administration. Transfersomes can overcome the challenges of transdermal administration of drugs because of their deformable nature, allowing for greater skin penetration than other formulations. However, due to an enormous number of product and process variables, the manufacturing of transfersomes proved a pain. The goal of the research study was to use a Plackett‐Burman design to evaluate an important product and process variables connected with the preparation of methotrexate transfersomes. The influence of six product and process variables on %entrapment efficiency and vesicle deformability was investigated and according to p‐values, and the Pareto chart, the concentration of lipid, edge activator, and methotrexate were found critical variables influencing vesicle features having positive and negative effects on variables. In the future, experimental design may be used to optimize these critical parameters for further exploration in the development of methotrexate transfersomes.