bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between perceived threat of COVID‐19 and burnout among frontline nurses: A mediation analysis
Authors: Gisilanbe Vetbuje Benard , Farmanesh Panteha , Sousan Arman 
Published: May 2022

AbstractBackgroundBurnout of nurses during the Coronavirus of 2019 pandemic can end up extremely expensive for societies. It is found that positive religious coping (PRC) and a secure God attachment are effective for shielding against the adverse consequences of being exposed to stressful situations.MethodsThis research explores the relationships among God attachment, religious coping, and burnout among nurses who are confronted with COVID‐19 as a perceived threat through a model based on the combination of attachment theory and the Job Demands‐Resources model. Analysis was done using SMART‐PLS.ResultsThe results reveal that perceived threat of COVID‐19 (PTC) positively correlates with burnout among nurses and that secure attachment to God and PRC can buffer this relationship, while insecure attachment to God, including anxious and avoidant attachment, along with negative religious coping positively mediates the relationship between PTC and burnout.ConclusionFinally, this study suggests managerial implications of these findings for healthcare organizations and a recommendation for helping out staff to help them manage such threats and their attachment to God.
Protective Effects of Grapefruit Essential Oil againstStaphylococcus Aureus‐Induced Inflammation and Cell Damage in Human Epidermal Keratinocytes
Authors: Zhang Xiaona , Xu Heran , Hua Jinglin , Zhu Ziying , Wang Min 
Published: May 2022

AbstractStaphylococcus aureus(S. aureus) is a common skin pathogenic bacterium, over‐colonization can induce skin infections, while its metabolites can also produce irritation to the skin, often accompanied by eczema dermatitis, specific dermatitis and other skin diseases. Grapefruit essential oil is extracted from the fruit of grapefruit (Citrus maxima(Burm) Merr.), a citrus plant that is rich in flavonoids, phenolic acids and high flavanones. Due to its good odor and biological activity such as anti‐inflammatory, antibacterial, etc., grapefruit essential oil has been widely used as an additive in food. To evaluate the potential application of grapefruit essential oil as raw materials in cosmetics products and health foods, we developed a cell damage model of skin inflammation stimulated byS. aureusmetabolites. Compared to that of lime essential oil, an internal control, we found that grapefruit essential oil could significantly promote HaCaT cells proliferation, reduce reactive oxygen species (ROS) production induced byS. aureusmetabolites, inhibit the upregulated expression of IL‐1 and COX‐2. In the 3D epidermal model, grapefruit essential oil could recover the decreased LOR and FLG contents caused byS. aureusmetabolites. These results demonstrated pharmacological evidence for the anti‐inflammatory effect of grapefruit essential oil, suggesting a potential application of grapefruit essential oil as cosmetic raw materials for repair and alleviating of skin inflammation caused byS. aureus.
Essential Oils of Three Balkan Abies Species: Chemical Profiles, Antimicrobial Activity and Toxicity toward Artemia salina and Drosophila melanogaster
Authors: Mitić Zorica S. , Stojanović‐Radić Zorica Z. , Jovanović Snežana Č. , Cvetković Vladimir J. , Nikolić Jelena S. , Ickovski Jovana D. , Mitrović Tatjana Lj. , Nikolić Biljana M. , Zlatković Bojan K. , Stojanović Gordana S. 
Published: May 2022

AbstractThis study focused on the essential oils (EOs) isolated from needles with twigs of three indigenous Balkan Abies species (A. alba, A. × borisii‐regis and A. cephalonica) regarding their chemical composition, antimicrobial activity and toxicity toward crustaceans and insects. Even though distinct phytochemical profiles of dominant volatiles were revealed for each species, β‐pinene and α‐pinene represented the first two major volatiles in all three EOs. Antimicrobial activity of EOs has shown inhibitory effect against all 17 studied strains (ATCC and respiratory isolates) in the range of 0.62–20.00 mg/mL (MICs). Further, all three EOs exhibited strong toxicity (LC50<100 μg/mL) in Artemia salina lethality bioassay, but with significant differences that depended on the EO type. Additionally, tested EOs have shown a certain level of toxicity against Drosophila melanogaster, mostly at the highest tested concentration (3 %) which caused significant prolongation of developmental time, larvicidal effect and pupal mortality. In the three biological assays performed, there was no observed inhibitory effect or weakest activity for A. alba EO. Further, A. cephalonica EO has shown the highest levels of antimicrobial activity and toxicity toward A. salina, while in relation to the insecticidal potential, A. cephalonica and A. × borisii‐regis EOs exhibited similar level of toxicity against D. melanogaster.
Effects of water, salt, and mixing on the rheological properties of bread dough at large and small deformations: A review
Authors: Sun Xinyang , Koksel Filiz , Scanlon Martin G. , Nickerson Michael T. 
Published: May 2022

AbstractBackground and ObjectiveA direct relationship between dough rheology and bread quality has been clearly revealed to show remarkable significance of studying dough rheological properties throughout breadmaking processes. This review paper has presented the effects of basic ingredients and mixing conditions on dough rheological properties at large and small deformations.FindingsAt both large and small deformations, dough rheological parameters have indicated that the variation in dough strength is due to a manipulation of ingredients and mixing conditions. The rheological properties of doughs over a wide range of formulations and processing conditions have been well characterized using the basic rheological models varying in the degree of complexity. Particularly, a power‐law gel model with only two parameters has a good ability for describing the strength and linear viscoelastic behavior of dough.ConclusionsTo devise strategies for achieving a desirable product quality, a deep understanding of the effects of ingredients and mixing conditions on dough rheology is in great need.Significance and NoveltyDough rheology insights not only benefit the bakery industry by screening suitable wheat flours for breadmaking, but also provide knowledge of how to improve dough handling properties during bakery manufacturing.
Can the Omicron variant of COVID‐19 cause pneumonia in young patients without risk factors?
Authors: Ito Noriaki , Kitahara Yoshihiro , Miwata Kei , Okimoto Mafumi , Takafuta Toshiro 
Published: May 2022

AbstractThe Omicron variant (B.1.1.529) of coronavirus disease 2019 (COVID‐19) has rapidly spread worldwide since December 2021. In daily medical practice, pneumonia does not often appear as a complication of the Omicron variant. We present a case of COVID‐19 pneumonia by the Omicron variant in young patients without obvious risk factors.
Chiral probe for mass spectrometric identification and quantitation of levodropropizine and its enantiomer, dextrodropropizine
Authors: Zhang Caiyu , Liu Yang , Liu Rui , Li Wei , Liu Changxiao , He Lan 
Published: May 2022

AbstractAcyl chlorides react rapidly with hydroxyl and amino groups in the absence of catalysts and therefore hold great promise for chiral mass spectrometry. Herein, a tandem mass spectrometry method based on derivatization with (−)‐camphanic acid chloride as a simple chiral probe was developed for the highly sensitive detection and quantitation of levodropropizine and its enantiomer, namely, dextrodropropizine. The diastereomeric derivatization products were quantified based on the relative abundances of their fragment ions produced upon collision‐induced dissociation in positive‐ion mode. The reactive site was elucidated using nuclear magnetic resonance spectroscopy and two‐dimensional total correlation spectroscopy, and the reaction mechanism was proved by stoichiometry studies. The degree of isomer recognition was investigated at different collision energies and determined as Rchiral ≈ 1.5. Thus, this study gives the way to the mass spectrometric identification and quantitation of levodropropizine and its enantiomer, and the developed method represents a new and practical technique for rapid and sensitive determination and quality control of enantiomers of chiral drugs.
Biocatalytic asymmetric synthesis of secondary allylic alcohols using Burkholderia cepacia lipase immobilized on multiwalled carbon nanotubes
Authors: Dias Michele do Rocio Gonçalves , da Silva Gesieli Prado Cardoso , de Pauloveloso Alysson , Krieger Nadia , Pilissão Cristiane 
Published: May 2022

AbstractThe lipase from Burkholderia cepacia (BCL) was immobilized through physical adsorption on pristine and functionalized multiwalled carbon nanotubes (MWCNTs) with carboxyl or amine groups and used in the stereoselective acylation of (R,S)‐1‐octen‐3‐ol (1) and (R,S)‐(E)‐4‐phenyl‐3‐buten‐2‐ol (4) with vinyl acetate. All immobilized preparations produced better results than free BCL. For (R,S)‐4, 50% conversion and E > 200 were obtained in n‐hexane or in solvent‐free medium. For (R,S)‐1, in solvent‐free medium, the conversion was 38% with a slight increase in the E‐value (E = 10).
A frequency divider using interacting self‐sustained pulses in a tunnel‐diode‐oscillator lattice
Authors: Narahara Koichi 
Published: May 2022

SummaryAn effective method for frequency division, which uses interacting self‐sustained solitary waves propagating in a one‐dimensional tunnel‐diode oscillator lattice, is discussed. When two pulses are input successively, it is found that there is a threshold separation below which the following pulse is significantly attenuated to disappear on the way, which only slightly influences the leading pulse. This phenomenon results in an efficient frequency divider with a high division ratio, which requires a relatively small number of lattice cells. In this study, we illustrate the fundamental dynamics of the self‐sustained pulse interactions and principal operation of frequency division with several experimental validations.
Fecal microbiota and diets of muskox female adults and calves
Authors: Cheon Ji‐Yeon , Cho Hyunjun , Kim Mincheol , Park Hyun Je , Park Tae‐Yoon S. , Lee Won Young 
Published: May 2022

AbstractIn mammals, the gut microbiome is vertically transmitted during maternal lactation at birth. In this study, we investigated the gut microbiome and diets of muskox, a large herbivore inhabiting in the high Arctic. We compared the microbiota composition using bacterial 16S rRNA gene sequencing and diets using stable isotope analysis of muskox feces of six female adults and four calves on Ella Island, East Greenland. Firmicutes were the most abundant bacterial phylum in both the adults and calves, comprising 94.36% and 94.03%, respectively. Significant differences were observed in the relative abundance of the two Firmicutes families. The adults were primarily dominated by Ruminococcaceae (73.90%), and the calves were dominated by both Ruminococcaceae (56.25%) and Lachnospiraceae (24.00%). Stable isotope analysis of the feces in the study area revealed that both adults and calves had similar ranges of 13C and 15N, likely derived from the dominant diet plants. Despite their similar diets, the different gut microbiome compositions in muskox adults and calves indicate that the gut microbiome of the calves may not be fully colonized to the extent of that of the adults.
Efficient Asymmetric Synthesis of an A‐Ring Synthon for Pd‐Catalyzed Preparation of 1α‐Hydroxyvitamin D Metabolites and Analogs
Authors: Loureiro Julian , Kattner Lars , Mouriño Antonio 
Published: May 2022

AbstractThe secondary parallel hypercalcemic effects associated with the treatment of several hyperproliferative diseases with the natural hormone 1α,25‐dihydroxyvitamin D3 (calcitriol) and/or known active vitamin D metabolites and analogs, demand the development of efficient and rapid methods for the preparation of vitamin D receptor (VDR) ligands as new selective and non‐calcemic agonists. Here we describe an efficient and adaptable multigram‐scale synthetic sequence to access an A‐ring synthon as useful precursor of the vitamin D triene system of 1α‐hydroxylated vitamin D derivatives via Pd‐catalyzed carbocyclization/Suzuki–Miyaura cross‐coupling reactions in a protic medium. The key step is an asymmetric Lewis acid‐promoted carbonyl‐ene reaction to a chiral glyosylate ester to establish the 1α‐hydroxyl group of 1α,25‐dihydroxyvitamin D3 and its derivatives.
An attention‐based synthetic battery data augmentation technique to overcome limited dataset challenges
Authors: Channegowda Janamejaya , Maiya Vageesh , Joshi Niharika , Raj Urs Vinayak , Lingaraj Chaitanya 
Published: May 2022

AbstractLarge‐scale global efforts for electrifying different modes of transportation have fueled the need for energy‐dense storage systems. Lithium‐ion batteries have shown promise to be a favourable technology to power pure electric vehicles, off‐board storage systems for microgrids and other hybrid vehicle applications. Accurate estimation of vital battery parameters, such as state‐of‐charge, enable the user to predict remaining useful life of lithium‐ion batteries. Although multiple data‐driven techniques over the years have improved prediction accuracy, lack of high‐quality data continues to be a challenge which has been largely ignored in literature. Commercial battery manufacturers fail to release their datasets due to privacy concerns thereby worsening this crisis. The limited data challenge has been further aggravated due to advent of novel charging techniques, such as pulsed discharge and constant‐temperature charging profile. This article aims to resolve this data scarcity issue by employing an attention‐based technique to generate reliable synthetic data. The generated data will greatly assist researchers to develop reliable battery ageing prediction models. The approach followed in this article consumes very less computational resources as well.
How do firms hedge in financial distress?
Authors: Dudley Evan , Andrén Niclas , Jankensgård Håkan 
Published: May 2022

AbstractWe examine how firms hedge in financial distress. Using hand‐collected data from oil and gas producers, we find that these firms hedge oil prices during periods of financial distress. Derivative portfolios in these firms are characterized by short put options. These positions are part of a composite three‐way (3W) collar strategy that combines buying put options and selling put and call options with differing strike prices. Because liquidity demand varies with the degree of financial distress, the 3W collar strategy preserves incentives for future growth.
“We'd be really motivated to do something about it”: A qualitative study of parent and clinician attitudes towards predicting childhood obesity in practice
Authors: Canfell Oliver J. , Littlewood Robyn , Wright Olivia R. L. , Walker Jacqueline L. 
Published: May 2022

AbstractIssue addressedIn Australia, one in four (24.9%) children live with overweight or obesity (OW/OB). Identifying infants at risk of developing childhood OW/OB is a potential preventive pathway, but its acceptability is yet to be investigated in Australia. This study aimed to (1) investigate the acceptability of predicting childhood OW/OB with parents of infants (aged 0‐2 years) and clinicians and (2) explore key language to address stigma and maximise the acceptability of predicting childhood OW/OB in practice.MethodsThis was a cross‐sectional and qualitative design, comprising individual semi‐structured interviews. Participants were multidisciplinary paediatric clinicians (n = 18) and parents (n = 13) recruited across public hospitals and health services in Queensland, Australia. Data were analysed under the Framework Method using an inductive, thematic approach.ResultsFive main themes were identified: (1) Optimism for prevention and childhood obesity prediction, (2) parent dedication to child's health, (3) adverse parent response to risk for childhood obesity, (4) language and phrasing for discussing weight and risk and (5) clinical delivery. Most participants were supportive of using a childhood OW/OB prediction tool in practice. Parents expressed dedication to their child's health that superseded potential feelings of judgement or blame. When discussing weight in a clinical setting, the use of sensitive (ie, “overweight”, “above average”, “growth” versus “obesity”) and positive, health‐focused language was mostly supported.ConclusionsMultidisciplinary paediatric clinicians and parents generally accept the concept of predicting childhood OW/OB in practice in Queensland, Australia.So what?Clinicians, public health and health promotion professionals and policymakers can act now to implement sensitive communication strategies concerning weight and obesity risk.
Entropy generation on unsteady stagnation‐point Casson nanofluid flow past a stretching sheet in a porous medium under the influence of an inclined magnetic field with homogeneous and heterogeneous reactions
Authors: Mahato R. , Das M. , Sen S. S. S. , Shaw S. 
Published: May 2022

AbstractThis study explores the entropy generation analysis on unsteady nonlinear radiative ethylene glycol‐based Casson nanofluid flow near stagnation point towards a stretching sheet through a porous medium. Analysis has been accomplished in the presence of an inclined magnetic field, heat generation, homogeneous–heterogeneous reactions, and viscous dissipation with velocity slip and convective boundary conditions. The nondimensional governing equations are solved by the shooting technique with the help of the RK45 method. We have experimented with copper and silver nanoparticles and a comparative analysis has been highlighted for both copper and silver nanofluids. Numerical outcomes are executed by the MATLAB built‐in bvp4c function. The consequences of the experiment for various pertinent flow parameters are portrayed by graphs and tables for both the Ag‐ and Cu‐Casson nanofluids. Results reveal that the enhancement of nanoparticles volume fraction accelerates temperature but it slows down concentration and velocity distributions. Higher values of the Eckert number boost velocity and temperature but reduce skin friction coefficient and Nusselt number. Enhancement of the Brinkman number boosts up entropy generation but it slows down Bejan's number. The results of the model can be applied in the movement of biological fluids, separation of biomolecules, glass manufacturing, paper production, food processing, crude oil purification, polymer drag reduction, and cooling atomic reactors.
The differentially expressed proteins related to clinical viral encephalitis revealed by proteomics
Authors: Wang Qian , Yan Shan‐Shan , Zhang Jun‐Yan , Du Ruo‐Lan , Xue Lu‐Lu , Li Juan , Yu Chang‐Yin 
Published: May 2022

AbstractTo screen out the prospective biomarkers of viral encephalitis (VE), analyze the biological process and signaling pathways involved by differentially expressed proteins (DEPs). A total of 11 cerebrospinal fluid (CSF) samples with VE and 5 with non‐nervous system infection were used to perform label‐free proteomic techniques. Then, the bioinformatic analysis of DEPs was applied by Interproscan software. Moreover, 73 CSF samples in the VE group and 53 in the control group were used to verify the changes of some DEPs by enzyme‐linked immunosorbent assay (ELISA). Thirty‐nine DEPs were identified, including 18 upregulated DEPs and 21 downregulated DEPs. DEPs were mainly enriched in cell adhesion molecules by Kyoto Encyclopedia of Genes and Genomes analysis pathway analysis. The DEPs related to axon tissue were obviously downregulated and the most significant downregulated proteins were neurexin 3, neurofascin, and neuroligin 2 (NLGN2). Moreover, the protein expression of NLGN2 in the VE group was significantly higher than that in the control group by ELISA. The correlation analysis of NLGN2 in the VE group revealed that there was a weak positive correlation with CSF protein and a weak negative correlation with CSF chloride. The clinical VE may be closely related to NLGN2 and the cell adhesion molecule pathway.
Yes, but … We need reliability to advance infant work, but there's more to consider too: Important nuances of reliability and the need to include validity
Authors: Kucker Sarah C. , Chmielewski Michael 
Published: May 2022

AbstractThe field of development needs more reliable infant work – improving our measures and methods is at the heart of accurately understanding why children do what they do! However, as scientists, we cannot stop with reliability but must also include measures of validity in our studies. In this commentary, we clarify and expand upon discussions of reliability and measurement error. We also argue for the importance of assessing the validity of our measures and tasks. Indeed, careful considerations of both reliability and validity are necessary for improving infant research.Highlights
Improving the reliability of infant work is critical; however, reliability by itself is not sufficient for advancing science.
Capturing multiple types of reliability and indices of validity will lead to the best measures and tools for researchers.
A careful consideration of both reliability and validity are necessary for improving infant research.
Efficacy of cabozantinib therapy for brain metastases from renal cell carcinoma
Authors: Nakagawa Takashi , Kijima Toshiki , Imasato Naoki , Nagoshi Akihiko , Nakamura Gaku , Uematsu Toshitaka , Suzuki Issei , Nishihara Daisaku , Kamai Takao 
Published: May 2022

IntroductionWe report two cases of renal cell carcinoma with brain metastases that showed remarkable responses to cabozantinib.Case presentation(Case 1) A 70‐year‐old man with cT3aN0M0 clear cell renal cell carcinoma underwent radical nephrectomy and developed multiple brain metastases 2 months postoperatively. The brain lesions regressed after stereotactic radiotherapy followed by ipilimumab plus nivolumab therapy, but a new brain metastasis that caused hemiplegia developed after 6 months and showed no response to stereotactic radiotherapy. However, complete remission was achieved, and hemiplegia ceased within 2 weeks of cabozantinib therapy. (Case 2) A 63‐year‐old man with cT3aN0M1 clear cell renal cell carcinoma and brain metastases underwent upfront cytoreductive nephrectomy. The brain lesions progressed rapidly 1 month postoperatively. The lesions disappeared 2 weeks after cabozantinib plus nivolumab therapy.ConclusionCabozantinib, alone or in combination with immune checkpoint inhibitors, may be a viable option for clear cell renal cell carcinoma with brain metastases.