bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of Pregnancy in Women With D‐Transposition of the Great Arteries: A Systematic Review
Authors: Pizula Jena , Devera Justin , Ng Tien M. H. , Yeung Samantha L. , Thangathurai Jenica , Herrick Nichole , Chatfield Amy J. , Mehra Anil , Elkayam Uri 
Published: November 2022

Background
Information on maternal and fetal outcomes of pregnancy in women with D‐transposition of the great arteries is limited. We conducted a systematic literature review on pregnancies in women with transposition of the great arteries after atrial and arterial switch operations to better define maternal and fetal risk.

Methods and Results

A systematic review was performed on studies between 2000 and 2021 that identified 676 pregnancies in 444 women with transposition of the great arteries. A total of 556 pregnancies in women with atrial switch operation were tolerated by most cases with low mortality (0.6%). Most common maternal complications, however, were arrhythmias (9%) and heart failure (8%) associated with serious morbidity in some patients. Worsening functional capacity, right ventricular function, and tricuspid regurgitation occurred in ≈20% of the cases. Rate of fetal and neonatal mortality was 1.4% and 0.8%, respectively, and rate of prematurity was 32%. A total of 120 pregnancies in women with arterial switch operation were associated with no maternal mortality, numerically lower rates of arrhythmias and heart failure (6% and 5%, respectively), significantly lower rate of prematurity (11%;
P
<0.001), and only 1 fetal loss.

Conclusions
Pregnancy is tolerated by most women with transposition of the great arteries and atrial switch operation with low mortality but important morbidity. Most common maternal complications were arrhythmias, heart failure, worsening of right ventricular function, and tricuspid regurgitation. There was also a high incidence of prematurity and increased rate of fetal loss and neonatal mortality. Outcome of pregnancy in women after arterial switch operations is more favorable, with reduced incidence of maternal complications and fetal outcomes similar to women without underlying cardiac disease.
Risk Factors for Delayed Cerebral Ischemia in Good‐Grade Patients With Aneurysmal Subarachnoid Hemorrhage
Authors: Rautalin Ilari , Juvela Seppo , Martini Michael L. , Macdonald Robert Loch , Korja Miikka 
Published: November 2022

Background
A subset of good‐grade patients with aneurysmal subarachnoid hemorrhage (aSAH) develop delayed cerebral ischemia (DCI) that may cause permanent disabilities after aSAH. However, little is known about the risk factors of DCI among this specific patient group.

Methods and Results

We obtained a multinational cohort of good‐grade (Glasgow Coma Scale 13–15 on admission) patients with aSAH by pooling patient data from 4 clinical trials and 2 prospective cohort studies. We collected baseline data on lifestyle‐related factors and the clinical characteristics of aSAHs. By calculating fully adjusted risk estimates for DCI and DCI‐related poor outcome, we identified the most high‐risk patient groups. The pooled study cohort included 1918 good‐grade patients with aSAH (median age, 51 years; 64% women), of whom 21% and 7% experienced DCI and DCI‐related poor outcome, respectively. Among men, patients with obesity and (body mass index ≥30 kg/m
2
) thick aSAH experienced most commonly DCI (33%) and DCI‐related poor outcome (20%), whereas none of the normotensive or young (aged <50 years) men with low body mass index (body mass index <22.5 kg/m
2
) had DCI‐related poor outcome. In women, the highest prevalence of DCI (28%) and DCI‐related poor outcome (13%) was found in patients with preadmission hypertension and thick aSAH. Conversely, the lowest rates (11% and 2%, respectively) were observed in normotensive women with a thin aSAH.

Conclusions
Increasing age, thick aSAH, obesity, and preadmission hypertension are risk factors for DCI in good‐grade patients with aSAH. These findings may help clinicians to consider which good‐grade patients with aSAH should be monitored carefully in the intensive care unit.
Association of Depression Onset and Treatment With Blood Pressure Control After Intracerebral Hemorrhage
Authors: Keins Sophia , Abramson Jessica R. , Mallick Akashleena , Pablo Castello Juan , Rodriguez-Torres Axana , Popescu Dominique , Hoffman Danielle , Kourkoulis Christina , Gurol M. Edip , Greenberg Steven M. , Anderson Christopher D. , Viswanathan Anand , Rosand Jonathan , Biffi Alessandro 
Published: November 2022

Background:
Blood pressure (BP) control represents a crucial intervention to improve long-term outcomes following spontaneous intracerebral hemorrhage (ICH). However, fewer than half of ICH survivors achieve target treatment goals. ICH survivors are also at very high risk for poststroke depression, which may contribute to inadequate BP control. We, therefore, sought to determine whether depressive symptoms after ICH are associated with inadequate BP control. We also investigated whether associations between depression after ICH and BP measurements were mediated by treatment with selective serotonin reuptake inhibitors or norepinephrine-serotonin reuptake inhibitors antidepressants.

Methods:
We leveraged data from a single-center longitudinal study of ICH conducted at Massachusetts General Hospital (Boston, MA) between 2006 and 2018. We collected data from semiautomated review of electronic health records, baseline and follow-up interviews, and computed tomography imaging. Information on BP measurements, depression diagnoses, antidepressants medication use, and medical visits were collected longitudinally and analyzed using mixed effects models. Primary outcomes included systolic and diastolic BP measurements during long-term follow-up after ICH.

Results:

We included 1243 consecutive ICH patients without pre-stroke depression history. Of these, 721 (58%) were diagnosed with incident depression over a median follow-up time of 52.8 months (interquartile range, 42.1–60.5). Depression onset was associated with subsequent increase in systolic (+8.3 mm Hg, SE, 2.4 mm Hg,
P
=0.012) and diastolic (+4.4 mm Hg, SE, 1.2 mm Hg) BP measurements. Resolution of depressive symptoms was associated with subsequent decrease in systolic (−5.9 mm Hg, SE, 1.4 mm Hg,
P
=0.031) and diastolic (−3.4 mm Hg, SE, 1.1 mm Hg,
P
=0.041) BP measurements. We also found associations between higher systolic BP measurements and use of selective serotonin reuptake inhibitor and noradrenaline-serotonin reuptake inhibitor antidepressants, independent of whether depression symptoms were active or not (all
P
<0.05).

Conclusions:
ICH survivors displayed increasing BP values after receiving a diagnosis of depression, followed by decreasing values among those experiencing resolution of depressive symptoms. Use of selective serotonin reuptake inhibitor and noradrenaline-serotonin reuptake inhibitor antidepressants was independently associated with higher systolic BP measurements. Clinicians ought to closely monitor BP for ICH survivors being treated for depression, especially using selective serotonin reuptake inhibitor and noradrenaline-serotonin reuptake inhibitor. Future studies will also be required to investigate the mechanisms underlying these associations.
Architecture for Real-Time Granular Synthesis With Per-Grain Processing: EmissionControl2
Authors: Roads Curtis , Kilgore Jack , DuPlessis Rodney 
Published: November 2022

AbstractEmissionControl2 (EC2) is a precision tool that provides a versatile and expressive platform for granular synthesis education, research, performance, and studio composition. It is available as a free download on all major operating systems.In this article, we describe the theoretical underpinnings of the software and expose the design choices made in creating this instrument. We present a brief historical overview and cover the main features of EC2, with an emphasis on per-grain processing, which renders each grain as a unique particle of sound. We discuss the graphical user interface design choices, the theory of operation, and intended use cases that guided these choices. We describe the architecture of the real-time per-grain granular engine, which emits grains in synchronous or asynchronous streams. We conclude with an evaluation of the software.
Meta-Learning the Difference: Preparing Large Language Models for Efficient Adaptation
Authors: Hou Zejiang , Salazar Julian , Polovets George 
Published: November 2022

Abstract
Large pretrained language models (PLMs) are often domain- or task-adapted via finetuning or prompting. Finetuning requires modifying all of the parameters and having enough data to avoid overfitting while prompting requires no training and few examples but limits performance. Instead, we prepare PLMs for data- and parameter-efficient adaptation by learning to learn the difference between general and adapted PLMs. This difference is expressed in terms of model weights and sublayer structure through our proposed dynamic low-rank reparameterization and learned architecture controller. Experiments on few-shot dialogue completion, low-resource abstractive summarization, and multi-domain language modeling show improvements in adaptation time and performance over direct finetuning or preparation via domain-adaptive pretraining. Ablations show our task-adaptive reparameterization (TARP) and model search (TAMS) components individually improve on other parameter-efficient transfer like adapters and structure-learning methods like learned sparsification.
The Modern Subject Sensing its Agency: Khalīl al-Khūrī’s Aesthetics of “Truth Mingled with Passion”
Authors: Guth Stephan 
Published: November 2022

Abstract
In the introduction to what is often labelled “the first Arabic novel”, Khalīl al-Khūrī’s Way, idhan lastu bi-Ifranjī (1859), the author not only criticises contemporary Westernisation, but also outlines a new aesthetics that integrates authenticity, logical plausibility, and passion (hawas). This article explains how al-Khūrī’s advocacy of the “indigenous way of life”, literary authenticity, and an emotionalisation of writing belong together. They spring from the same source, just as does the temporalisation inherent in the nahḍa’s predilection for plot narratives: the modern subject beginning to sense its agency and seeking to assert itself.
Legal Humility and Perceptions of Power in International Criminal Justice
Authors: Palmer Nicola , Hamilton Tomas 
Published: November 2022

Abstract
This article examines how judges and lawyers working in international criminal courts see their authority in relation to power exerted by states, international organisations and private actors. We draw together ethnographic research inside the International Criminal Tribunal for Rwanda (ictr) and the International Criminal Court (icc) that examined perceptions of the interactions among local, national and international legal regimes and the potential for accomplice liability for arms traders under international criminal law. Overall, we show that the legal actors in these courts routinely understood their power as severely limited by concurrent sites of private and public authority. Building on ideas of legal humility, we argue that this should be understood as ‘selective humility’. This humility demonstrated a reticence among these legal actors about what internationalised courts can achieve while offering an argumentative defence against critiques of this legal practice.
Religious Actors, Care, and Mood in the Time of COVID-19
Authors: Jammes Jérémy , Hoon Chang-Yau 
Published: November 2022

Abstract
The introduction to this special issue considers the interdisciplinary study of religious sentiments, religious care and social actions during the COVID-19 outbreak in South-, East- and Southeast Asia. Our approach in terms of nodes and polarisation allows one to visualise a bundle of religious and secular actors and interests, as well as original strategies and actions, in time of pandemic, which sometimes challenge local regimes of truth and authority. In many cases, faith-based NGO s have been complementing the State, activating their powerful channels of mission in urban and rural areas, under the guise of combating COVID-19 crisis. The studies presented here examine several Asian religious actors during this period of COVID-19 crisis; and the ways in which their creative digitalised measures of worship, protection and healing, and their participation in urgent public health and care provisions, have given them the opportunity to renegotiate their relationships with States and societies.
Neoephemeridae (Insecta, Ephemeroptera) of the Philippines and Insights on Southeast Asian biodiversity
Authors: Garces Jhoana M. , Sartori Michel 
Published: November 2022

Abstract
A new mayfly species, Potamanthellus panayensis sp. n. (Neoephemeridae) is described from Panay Island, Philippines, based on nymphs. Supplementary nymphal description of P. caenoides (Ulmer, 1939) and a provisional description of another Potamanthellus species from Mindanao Island, Philippines are provided. The potential underestimated diversity of Potamanthellus in Southeast Asia is discussed in line with the species delimitation in this study based on COI sequences.
Streamflow Composition and the Contradicting Impacts of Anthropogenic Activities and Climatic Change on Streamflow in the Amu Darya Basin, Central Asia
Authors: Hou Mei , Cuo Lan , Murodov Amirkhamza , Ding Jin , Luo Yi , Liu Tie , Chen Xi 
Published: November 2022

Abstract
Transboundary rivers are often the cause of water-related international disputes. One example is the Amu Darya River, with a catchment area of 470 000 km2, which passes through five countries and provides water resources for 89 million people. Intensified human activities and climate change in this region have altered hydrological processes and led to water-related conflicts and ecosystem degradation. Understanding streamflow composition and quantifying the change impacts on streamflow in the Amu Darya basin (ADB) are imperative to water resources management. Here, a degree-day glacier-melt scheme coupled offline with the Variable Infiltration Capacity hydrological model (VIC-glacier), forced by daily precipitation, maximum and minimum air temperature, and wind speed, is used to examine streamflow composition and changes during 1953–2019. Results show large differences in streamflow composition among the tributaries. There is a decrease in the snowmelt component (−260.8 m3 s−1) and rainfall component (−30.1 m3 s−1) at Kerki but an increase in the glacier melt component (160.0 m3 s−1) during drought years. In contrast, there is an increase in the snowmelt component (378.6 m3 s−1) and rainfall component (12.0 m3 s−1) but a decrease in the glacier melt component (−201.8 m3 s−1) during wet years. Using the VIC-glacier and climate elasticity approach, impacts of human activities and climate change on streamflow at Kerki and Kiziljar during 1956–2015 are quantified. Both methods agree and show a dominant role played by human activities in streamflow reduction, with contributions ranging 103.2%–122.1%; however, the contribution of climate change ranges from −22.1% to −3.2%.
Virtual screening of phytochemicals by targeting multiple proteins of severe acute respiratory syndrome coronavirus 2: Molecular docking and molecular dynamics simulation studies
Authors: Azeem Muhammad , Mustafa Ghulam , Mahrosh Hafiza S 
Published: November 2022

Objective Medicinal herbs are being investigated for medicationhg development against SARS-CoV-2 as a rich source of bioactive chemicals. One of the finest approaches for finding therapeutically effective drug molecules in real time is virtual screening scheme such as molecular docking in conjunction with molecular dynamics (MD) simulation. These virtual techniques provide an ample opportunity for the screening of plausible inhibitors of SARS-CoV-2 different target proteins from a comprehensive and extensive phytochemical library. The study was designed to identify potential phytochemicals by virtual screening against different receptor proteins. Methods In the current study, a library of plant secondary metabolites was created by manually curating 120 phytochemicals known to have antimicrobial as well as antiviral properties. In the current study, different potential phytochemicals were identified by virtual screening against various selected receptor proteins (i.e., viral main proteases, RNA-dependent RNA polymerase (RdRp), ADP ribose phosphatase, nonstructural proteins NSP7, NSP8, and NSP9) which are key proteins responsible for transcription, replication and maturation of SARS-CoV-2 in the host. Top three phytochemicals were selected against each viral receptor protein based on their best S-scores, RMSD values, molecular interactions, binding patterns and drug-likeness properties. Results The results of molecular docking study revealed that phytochemicals (i.e., baicalin, betaxanthin, epigallocatechin, fomecin A, gallic acid, hortensin, ichangin, kaempferol, limonoic acid, myricetin hexaacetat, pedalitin, quercetin, quercitrin, and silvestrol) have strong antiviral potential against SARS-CoV-2. Additionally, the reported preeminent reliable phytochemicals also revealed toxicity by no means during the evaluation through ADMET profiling. Moreover, the MD simulation study also exhibited thermal stability and stable binding affinity of the pedalitin with SARS-CoV-2 RdRp and SARS-CoV-2 main protease which suggests appreciable efficacy of the lead optimization. Conclusion The biological activity and pharmacologically distinguishing characteristics of these lead compounds also satisfied as repurposing antiviral drug contenders and are worth substantial evaluation in the biological laboratory for the recommendation of being plausible antiviral drug candidates against SARS-CoV-2.
In-situ temperature monitoring during rotary ultrasonic-assisted drilling of fiber-reinforced composites
Authors: Shard Abhinav , Agarwal Raj , Garg Mohinder Pal , Gupta Vishal 
Published: November 2022

Drilling polyetherimide composite is difficult due to the anisotropic and inhomogeneous structure of fiber and matrix. Drilling of fiber-reinforced composites is a thermo-mechanical friction procedure required in various aerospace and automotive applications. The major reason for component rejection during manufacturing processes is due to thermal damage and temperature elevation defects such as delamination and fiber pullout caused during drilling. This work aims to propose a rotary ultrasonic-assisted drilling technique for composite materials to reduce thermal damage using diamond-impregnated tools. The influence of drilling parameters such as rotational speed, feed rate, abrasive grit size, and ultrasonic power was monitored on temperature elevations. The temperature was monitored using thermocouples located at different distances of 1.0, 2.0, and 3.0 mm from the main drilled hole. The response surface methodology was used for the design of experiments during the drilling of composite material and optimization of process parameters was carried out using analysis of variance. Rotational speed and abrasive grit size were observed to have the highest contribution of 42% and 37% for temperature elevations respectively. It was witnessed that temperature increases with an increase in rotational speed, feedrate, and abrasive grit size. Increasing the ultrasonic power during drilling temperature can be minimized. The temperature elevations at the tool-composite interface can be reduced by leveraging the application of rotary ultrasonic-assisted drilling.
Mechanical and thermal properties of fully green composites from vanillin-based benzoxazine and silane surface modified chopped basalt fibers
Authors: Derradji Mehdi , Khiari Karim , Mehelli Oussama , Abdous Slimane , Habes Abdelmalek , Ramdani Noureddine , Zegaoui Abdeljalil , Liu Wenbin , Daham Abbas 
Published: November 2022

By following the rules of green chemistry, a novel composite is developed from a renewable and ecofriendly resource, namely the vanillin. The latter was used as a phenolic precursor for the microwave synthesis of a bio-based benzoxazine resin (Va-BZ). Afterwards, high performance green composites were developed by reinforcing the Va-BZ with various amounts of chopped silane surface modified basalt fibers (BFs). The chemical structure of the Va-BZ monomers was confirmed by 1H NMR and FTIR spectroscopy. The grafting of the silane moiety on the BFs surface was assessed by FTIR and TGA analyses. The autocatalytic ring opening polymerization of the Va-BZ monomers was confirmed by DSC analysis. The mechanical performances of the developed green composites were studied by flexural and tensile investigations. The findings suggested that the maximum amount of 20 wt. BFs afforded the best results, with flexural and tensile strengths of 447 and 460 MPa, respectively. The SEM was used to study the fractured tensile surfaces and elucidated the toughening mechanism. Meanwhile, the TGA showed that the introduction of the BFs markedly improved the thermal stability of the benzoxazine matrix. Finally, the gamma rays shielding effectiveness was studied and revealed the highly benefic role of the BFs. For instance, a 1 cm thick Va-BZ polymer only showed a 6% gamma rays screening ratio, the latter was improved to 18.4% for the composite made of 20 wt.% of treated BFs. Overall, this study confirmed that greener approaches can also result in high performance composite satisfying the needs of exigent applications.
Experimental study on the aerodynamic performance of variable geometry low-pressure turbine adjustable guide vanes
Authors: Yao Yunjia , Li Fengchao , Xiang Jiacheng , Song Liming , Li Jun 
Published: November 2022

An annular cascade testing rig of a variable-geometry low-pressure turbine with a large expansion angle was designed and built, combining a five-hole probe, a surface static pressure test system, and a PIV(Particle Image Velocimetry) measurement system. The effects of exit Mach numbers (0.2, 0.3, 0.4), turning angles (−1.5°, 0°, 3°), and adjustable device diameters (30 mm, 40 mm) on turbine cascade aerodynamic performance were experimentally investigated. Numerical simulations were also carried out to gain more insight into the flow fundamentals. Results show that the endwall clearance and the adjustable device significantly influence the flow field, with leakage flows before, after, and around the disc. The leakage vortex and passage vortex formation resulted in two high-loss regions in the shroud and hub endwall regions. The aerodynamic loss structures at the exit section were similar at different Mach numbers and varied considerably at different turning angles. Besides, a larger area of the adjustable device (d = 40 mm) was found to reduce the leakage loss caused by upper and lower clearance leakage flows and inhibit the development of secondary flows, resulting in a more straightforward secondary flow structure and a smaller influence range. Quantitatively, the adjustable device with a diameter of 40 mm could decrease the average total pressure loss coefficients by 11.5%, 16.6%, and 6.3% at three turning angles (−1.5°, 0°, 3°), respectively, compare to the adjustable device with a diameter of 30 mm.