bluuebunny/crossref_metadata_2025_split huggingface dataset:
The environmental pollutant, polychlorinated biphenyl 126, alters liver function in a rodent model of alcohol‐associated liver disease
Authors: Gripshover Tyler C. , Wahlang Banrida , Head Kimberly Z. , Young Jamie L. , Luo Jianzhu , Mustafa Muhammad T. , Kirpich Irina A. , Cave Matthew C. 
Published: November 2022

AbstractBackgroundThe prevalence of alcohol‐associated liver disease (ALD), a subtype of fatty liver disease (FLD), continues to rise. ALD is a major cause of preventable death. Polychlorinated biphenyl (PCB) 126 is an environmentally relevant, dioxin‐like pollutant whose negative metabolic effects have been well documented. In human and animal studies, PCB has been associated with the severity of nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated whether exposures to environmental toxicants can worsen ALD. Thus, the objective of the current study was to develop an alcohol‐plus‐toxicant model to study how an environmental pollutant, PCB 126, impacts rodent ALD pathology.MethodsBriefly, male C57BL/6J mice were exposed to 0.2 mg/kg PCB 126 or corn oil vehicle four days prior to ethanol feeding using the chronic‐binge (10‐plus‐one) model.ResultsConcentrations of macromolecules, including hepatic lipids, carbohydrates, and protein (albumin) were impacted. Exposure to PCB 126 exacerbated hepatic steatosis and hepatomegaly in mice exposed to the chemical and fed an ethanol diet. Gene expression and the analysis of blood chemistry showed a potential net increase and retention of hepatic lipids and reductions in lipid oxidation and clearance capabilities. Depletion of glycogen and glucose was evident, which contributes to disease progression by generating systemic malnutrition. Granulocytic immune infiltrates were present but driven solely by ethanol feeding. Hepatic albumin gene expression and plasma levels were decreased by ~50% indicating a potential compromise of liver function. Finally, gene expression analyses indicated that the aryl hydrocarbon receptor and constitutive androstane receptor were activated by PCB 126 and ethanol, respectively.ConclusionsVarious environmental toxicants are known to modify or enhance FLD in high‐fat diet models. Findings from the present study suggest that they interact with other lifestyle factors such as alcohol consumption to reprogram intermediary metabolism resulting in exacerbated ethanol‐associated systemic malnutrition in ALD.
Crohn's disease shared decision making intervention leads to more patients choosing combination therapy: a cluster randomised controlled trial
Authors: Zisman‐Ilani Yaara , Thompson Kimberly D. , Siegel Lori S. , Mackenzie Todd , Crate Damara J. , Korzenik Joshua R. , Melmed Gil Y. , Kozuch Patricia , Sands Bruce E. , Rubin David T. , Regueiro Miguel D. , Cross Raymond , Wolf Douglas C. , Hanson John S. , Schwartz Ronald M. , Vrabie Raluca , Kreines Michael D. , Scherer Timothy , Dubinsky Marla C. , Siegel Corey A. 
Published: November 2022

SummaryBackgroundCrohn's disease requires effective patient‐clinician communication for successful illness and medication management. Shared decision making (SDM) has been suggested to improve communication around early intensive therapy. However, effective evidence‐based SDM interventions for Crohn's disease are lacking, and the impact of SDM on Crohn's disease decision making and choice of therapy is unclear.AimTo test the impact of SDM on choice of therapy, quality of the decision and provider trust compared to standard Crohn's disease care.MethodsWe conducted a multi‐site cluster randomised controlled trial in 14 diverse gastroenterology practices in the US.ResultsA total of 158 adult patients with Crohn's disease within 15 years of their diagnosis, with no prior Crohn's disease complications, and who were candidates to receive immunomodulators or biologics, participated in the study. Among these, 99 received the intervention and 59 received standard care. Demographics were similar between groups, although there were more women assigned to standard care, and a slightly shorter disease duration among those in the intervention group. Participants in the intervention group more frequently chose combination therapy (25% versus 5% control, p < 0.001), had a significantly lower decisional conflict (p < 0.05) and had greater trust in their provider (p < 0.05).ConclusionsWith rapidly expanding medication choices for Crohn's disease and slow uptake of early intensive therapy, SDM can personalise treatment strategies and has the potential to move the field of Crohn's disease management forward with an ultimate goal of consistently treating this disease early and intensively in appropriate patients.Trial Registration: Evaluating a Shared Decision Making Program for Crohn's Disease, ClinicalTrials.gov Identifier NCT02084290 https://clinicaltrials.gov/ct2/show/NCT02084290.
Benefits of laparoscopic trans‐hiatal approach with Heller–Dor surgery in a case of mid‐esophageal diverticulum
Authors: Ueno Shuhei , Ogawa Ryo , Saito Masaki , Ito Sunao , Hayakawa Shunsuke , Okubo Tomotaka , Sagawa Hiroyuki , Tanaka Tatsuya , Takahashi Hiroki , Matsuo Yoichi , Mitsui Akira , Kimura Masahiro , Takiguchi Shuji 
Published: November 2022

AbstractCompared to the more common epiphrenic diverticula, those located at the central section of the esophagus are quite rare. Minimally invasive approaches for mid‐esophageal diverticula have lacked standardization. Certain mid‐esophageal diverticula, like epiphrenic diverticula, have been attributed to esophageal motility disorders. Thus, we believe that surgery for esophageal diverticula requires preoperative evaluation of esophageal function, with additional surgery being performed in case of abnormalities. The laparoscopic trans‐hiatal approach has been a common technique for managing epiphrenic diverticula but can also be used for mid‐esophageal diverticula located far from the esophagogastric junction provided that the port location is carefully considered. Laparoscopic surgery is also preferable given that it is a minimally invasive procedure and allows for diverticulum resection and Heller myotomy and Dor surgery to prevent reflux in the same field of view. Hence, laparoscopic surgery may be a beneficial alternative to the traditional thoracic or thoracoabdominal techniques.
Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project
Authors: Beunders Alexandra J. M. , Klaus Federica , Kok Almar A. L. , Schouws Sigfried N. T. M. , Kupka Ralph W. , Blumberg Hilary P. , Briggs Farren , Eyler Lisa T. , Forester Brent P. , Forlenza Orestes V. , Gildengers Ariel , Jimenez Esther , Mulsant Benoit H. , Patrick Regan E. , Rej Soham , Sajatovic Martha , Sarna Kaylee , Sutherland Ashley , Yala Joy , Vieta Eduard , Villa Luca M. , Korten Nicole C. M. , Dols Annemieke 
Published: November 2022

AbstractObjectivesThe distinction between bipolar I disorder (BD‐I) and bipolar II disorder (BD‐II) has been a topic of long‐lasting debate. This study examined differences between BD‐I and BD‐II in a large, global sample of OABD, focusing on general functioning, cognition and somatic burden as these domains are often affected in OABD.MethodsCross‐sectional analyses were conducted with data from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) database. The sample included 963 participants aged ≥50 years (714 BD‐I, 249 BD‐II). Sociodemographic and clinical factors were compared between BD subtypes including adjustment for study cohort. Multivariable analyses were conducted with generalized linear mixed models (GLMMs) and estimated associations between BD subtype and (1) general functioning (GAF), (2) cognitive performance (g‐score) and (3) somatic burden, with study cohort as random intercept.ResultsAfter adjustment for study cohort, BD‐II patients more often had a late onset ≥50 years (p = 0.008) and more current severe depression (p = 0.041). BD‐I patients were more likely to have a history of psychiatric hospitalization (p < 0.001) and current use of anti‐psychotics (p = 0.003). Multivariable analyses showed that BD subtype was not related to GAF, cognitive g‐score or somatic burden.ConclusionBD‐I and BD‐II patients did not differ in terms of general functioning, cognitive impairment or somatic burden. Some clinical differences were observed between the groups, which could be the consequence of diagnostic definitions. The distinction between BD‐I and BD‐II is not the best way to subtype OABD patients. Future research should investigate other disease specifiers in this population.
Religious preferences in healthcare: A welfarist approach
Authors: Crisp Roger 
Published: November 2022

AbstractThis paper offers a general approach to ethics before considering its implications for the question of how to respond to religious preferences in healthcare, especially those of patients and healthcare workers. The first section outlines the two main components of the approach: (1) demoralizing, that is, seeking to avoid moral terminology in the discussion of reasons for action; (2) welfarism, the view that our ultimate reasons are grounded solely in the well‐being of individuals. Section 2 elucidates the notion of religious preferences and describes the history and importance of their protection by human rights legislation. The following section defends the ‘Preference Principle’, according to which there is a reason to satisfy any preference (in so far as that satisfaction advances well‐being). Section 4 discusses the implications of this principle for religious preferences in healthcare, again seeking to bring out the special social and political importance of respect, and respect for such preferences in particular. The paper ends with a brief description of how to approach such problems from the perspective of a demoralized welfarism.
Clinical implementation of integrated molecular‐morphologic risk prediction for meningioma
Authors: Hielscher Thomas , Sill Martin , Sievers Philipp , Stichel Damian , Brandner Sebastian , Jones David T. W. , von Deimling Andreas , Sahm Felix , Maas Sybren L. N. 
Published: November 2022

AbstractRisk prediction for meningioma tumors was until recently almost exclusively based on morphological features of the tumor. To improve risk prediction, multiple models have been established that incorporate morphological and molecular features for an integrated risk prediction score. One such model is the integrated molecular‐morphologic meningioma integrated score (IntS), which allocates points to the histological grade, epigenetic methylation family and specific copy‐number variations. After publication of the IntS, questions arose in the neuropathological community about the practical and clinical implementation of the IntS, specifically regarding the calling of CNVs, the applicability of the newly available version (v12.5) of the brain tumor classifier and the need for incorporation of TERT‐promoter and CDKN2A/B status analysis in the IntS calculation. To investigate and validate these questions additional analyses of the discovery (n = 514), retrospective validation (n = 184) and prospective validation (n = 287) cohorts used for IntS discovery and validation were performed. Our findings suggest that any loss over 5% of the chromosomal arm suffices for the calling of a CNV, that input from the v12.5 classifier is as good or better than the dedicated meningioma classifier (v2.4) and that there is most likely no need for additional testing for TERT‐promoter mutations and/or homozygous losses of CDKN2A/B when defining the IntS for an individual patient. The findings from this study help facilitate the clinical implementation of IntS‐based risk prediction for meningioma patients.
Associations between dimensions of mental health literacy and adolescent help‐seeking intentions
Authors: Goodfellow Claire , Macintyre Anna , Knifton Lee , Sosu Edward 
Published: November 2022

BackgroundThe majority of long‐term mental health problems begin during adolescence. Low mental health literacy (MHL) may impede help‐seeking for these problems. Although MHL is a multidimensional construct and adolescent help‐seeking can be through formal and informal means, little is known about how dimensions of MHL influence these help‐seeking intentions. This study examines associations between dimensions of MHL and formal and informal help‐seeking intentions among adolescents. It also investigates whether informal help‐seeking mediates the association between dimensions of MHL and formal help‐seeking, and whether these associations are moderated by gender.MethodsA cross‐sectional survey including measures of MHL, and help‐seeking intentions was distributed to participants in 10 schools (12–17 years) across Scotland (n = 734). Data were analysed using Confirmatory Factor Analyses (CFA) and Structural Equation Modelling (SEM).ResultsConfirmatory Factor Analyses identified two distinct dimensions of MHL: ability to identify a mental health problem, and knowledge of treatment efficacy. Only knowledge of treatment efficacy was associated with increased intention to seek formal and informal help. Ability to identify a mental health problem was negatively associated with both forms of help‐seeking intentions. Informal help‐seeking mediated the association between both forms of MHL and formal help‐seeking. Gender did not moderate the associations between MHL and help‐seeking.ConclusionsCare should be taken when providing MHL interventions to ensure that adaptive forms of MHL are promoted. Future research should investigate possible mechanisms by which discrete forms of MHL influence adolescent help‐seeking as well as investigating other potential moderators of MHL and help‐seeking, such as stigma.
Hundreds of billions of silent outbreaks: A historic outbreak record of the gall midge Schizomyia castanopsisae (Diptera: Cecidomyiidae) on the Izu Islands, Tokyo, Japan, and its potential mechanism
Authors: Tokuda Makoto , Kawauchi Kota , Matsuda Hiroki , Naito Akinori , So Yoshifumi , Elsayed Ayman Khamis , Kikuchi Takeshi , Kotaka Nobuhiko 
Published: November 2022

AbstractHerbivore outbreaks cause serious damage to forest trees. In recent decades, outbreaks of the gall midge Schizomyia castanopsisae (Diptera: Cecidomyiidae) inducing inflorescence galls on Castanopsis sieboldii (Fagaceae) occurred in the Izu Islands, Tokyo, Japan. We investigated the gall density on the islands and estimated the larval population on Miyakejima Island. We also surveyed seasonal changes in larval age structure, presence of natural enemies, larval cold tolerance, and thermal effects on the adult emergence. In addition, we conducted molecular phylogenetic analyses of S. castanopsisae populations among different localities. The gall density was particularly high in southern parts (from Miyakejima to Aogashima) of the Izu Islands. The gall midge seemed to have been expanding its range toward northern parts in recent years. On Miyakejima, the larval population was estimated to be approximately 158 and 36 bn in 2017 and 2018, respectively. Parasitoids were not found in the dissection of galls. A cold temperature treatment did not affect the percentage of adult emergence. Developmental zero and thermal constant during the period from larval departure to adult emergence were estimated to be 4.7°C and 588.2°C‐days in males and 7.4°C and 476.2°C‐days in females, and the adults were predicted to emerge in April. Populations in Kyushu were genetically distinct from those in Okinawajima and the Izu Islands, but a common haplotype was found between the latter two localities. These imply that S. castanopsisae on the Izu Islands may be a recent invasion, and the absence of natural enemies causes its outbreaks.
Genomic prediction of carcass traits using different haplotype block partitioning methods in beef cattle
Authors: Li Hongwei , Wang Zezhao , Xu Lei , Li Qian , Gao Han , Ma Haoran , Cai Wentao , Chen Yan , Gao Xue , Zhang Lupei , Gao Huijiang , Zhu Bo , Xu Lingyang , Li Junya 
Published: November 2022

AbstractGenomic prediction (GP) based on haplotype alleles can capture quantitative trait loci (QTL) effects and increase predictive ability because the haplotypes are expected to be in linkage disequilibrium (LD) with QTL. In this study, we constructed haploblocks using LD‐based and the fixed number of single nucleotide polymorphisms (fixed‐SNP) methods with Illumina BovineHD chip in beef cattle. To evaluate the performance of different haplotype block partitioning methods, we constructed haploblocks based on LD thresholds (from r2 > 0.2 to r2 > 0.8) and the number of fixed‐SNPs (5, 10, 20). The performance of predictive methods for three carcass traits including liveweight (LW), dressing percentage (DP), and longissimus dorsi muscle weight (LDMW) was evaluated using three approaches (GBLUP and BayesB model based on the SNP, GHBLUP, and BayesBH models based on the haploblock, and GHBLUP+GBLUP and BayesBH+BayesB models based on the combined haploblock and the nonblocked SNPs, which were located between blocks). In this study, we found the accuracies of LD‐based and fixed‐SNP haplotype Bayesian methods outperformed the Bayesian models (up to 8.54 ± 7.44% and 5.74 ± 2.95%, respectively). GHBLUP showed a high improvement (up to 11.29 ± 9.87%) compared with GBLUP. The Bayesian models have higher accuracies than BLUP models in most scenarios. The average computing time of the BayesBH+BayesB model can reduce by 29.3% compared with the BayesB model. The prediction accuracies using the LD‐based haplotype method showed higher improvements than the fixed‐SNP haplotype method. In addition, to avoid the influence of rare haplotypes generated from haplotype construction, we compared the performance of GP by filtering four types of minor haplotype allele frequency (MHAF) (0.01, 0.025, 0.05, and 0.1) under different conditions (LD levels were set at r2 > 0.3, and the fixed number of SNPs was 5). We found the optimal MHAF threshold for LW was 0.01, and the optimal MHAF threshold for DP and LDMW was 0.025.
Understanding the cultural environment of the outpatient care setting for patients with dementia receiving cancer treatment: A qualitative study
Authors: Farrington Naomi , Dantanus Katherine , Richardson Alison , Bridges Jackie 
Published: November 2022

AbstractIntroductionPeople with dementia have poorer cancer outcomes than those without dementia, and experience inequalities in access to, and quality of, care. Outpatient environments, where radiotherapy, chemotherapy and immunotherapy cancer treatments typically take place, have largely been excluded from research. This study was conducted to understand provision of treatment and support and experiences of care for people with dementia undergoing cancer treatment in the outpatient setting.Materials and MethodsUsing observation, interviews and document analysis, data were collected to scrutinize the cultural environment of ambulatory care, comprising the physical fabric of the care setting; interactions, behaviours and perceptions of those in the care setting; and the organizational, clinical and interactional processes involved in care delivery. The study was conducted in the outpatient oncology departments of two large teaching hospitals in England between January 2019 and July 2021.ResultsData were gathered from a wide range of sources, including 15 h of observation, and interviews with patients (n = 2), caregivers (n = 7) and staff (n = 20). Evidence from this study suggests that the cultural environment of the outpatient care setting reflects and supports the standardized processing of people for cancer treatment. Dementia introduces a wider set of care requirements not catered for by this standardized treatment model and associated processes. Data showed that the needs of patients with dementia could be addressed most effectively when individualized care, as opposed to standardized care, was offered.ConclusionThere is work to be done in outpatient cancer services to ensure responsiveness to individual patient need. This could be achieved by having an established way (or ways) of eliciting needs, preferences and expectations, a belief that a person's needs and expectations are legitimate and that effort should be made to address them, with the ability to accommodate these needs and expectations.Patient or Public ContributionPatients and caregivers were involved in the study design and development of study materials including the interview topic guide. They also assisted with discussion and clarification of study findings.
Evaluating the role and effectiveness of co‐produced community‐based mental health interventions that aim to reduce suicide among adults: A systematic review
Authors: Hanlon Claire A. , McIlroy David , Poole Helen , Chopra Jennifer , Saini Pooja 
Published: November 2022

AbstractBackgroundSuicide is a major public health risk requiring targeted suicide prevention interventions. The principles of co‐production are compatible with tailoring suicide prevention interventions to meet an individual's needs.AimsThis review aimed to evaluate the role and effectiveness of co‐produced community‐based suicide prevention interventions among adults.MethodsFour electronic databases (PsycInfo, CINAHL, MEDLINE and web of science) were systematically searched. A narrative synthesis was conducted.ResultsFrom 590 papers identified through searches, 14 fulfilled the inclusion criteria. Most included studies elicited the views and perspectives of stakeholders in a process of co‐design/co‐creation of community‐based suicide prevention interventions.ConclusionStakeholder involvement in the creation of community‐based suicide prevention interventions may improve engagement and give voice to those experiencing suicidal crisis. However, there is limited evaluation extending beyond the design of these interventions. Further research is needed to evaluate the long‐term outcomes of co‐produced community‐based suicide prevention interventions.Patient and Public InvolvementThis paper is a systematic review and did not directly involve patients and/or the public. However, the findings incorporate the views and perspectives of stakeholders as reported within the studies included in this review, and the findings may inform the future involvement of stakeholders in the design, development and delivery of community‐based suicide prevention interventions for adults.
Changes in flooding in the alpine catchments of the Tarim River Basin, Central Asia
Authors: Fang Gonghuan , Li Zhi , Yang Jing , Chen Yaning , Duan Weili , Amory Charles , Wang Yunqian 
Published: November 2022

AbstractFloods are one of the most affective climate‐related disasters, and climate change has altered their intensity and frequency worldwide. This study examined long‐term changes in flood characteristics (including magnitude, frequency, and timing) in 30 alpine headwaters of the large endorheic Tarim River Basin, Central Asia. The contributions of climatic factors to flood (magnitude and timing) changes were investigated using numerical experiments in combination with the random forest approach. The following results were obtained: (1) Annual maximum flood peaks increased at most stations (89% stations) during 1961–2015 with increased flood frequency. Earlier flood peaks were observed in spring with a rate of 1.38 day per decade; for other seasons, changes in the occurrence time of flood peaks showed strong spatial variability. (2) Precipitation was the dominant factor for the increased flood magnitude in most catchments of the southern slope of the Tianshan Mountains, and temperature played a greater role in the northern Kunlun Mountains. (3) For flood timing changes, melt level height and precipitation were the most influential factors in the alpine catchments in the Tarim River Basin. The results provide information on the spatiotemporal variations of floods and their driving factors in this alpine basin under climate change.