bluuebunny/crossref_metadata_2025_split huggingface dataset:
An optimal content indexing approach for named data networking in software‐defined IoT system
Authors: Dudeja Rajan Kumar , Singh Amritpal , Bali Rasmeet Singh , Aujla Gagangeet Singh 
Published: February 2022

AbstractThe evolution of the Internet of Things (IoT) has increased the number of connected devices in the network. This has shifted the focus from IP‐based network architecture towards content‐centric networking (CCN). CCN eliminates the need for address‐content binding in the conventional IP‐based networks and allows the content to be accessed based on the name instead of the physical location. Named data networking (NDN) is a promising technique that can fulfil the increasing demand for connected devices through the CCN approach. NDN distributes the content on the network and focusses on the security of the content rather than the communication channel. However, the increase in traffic due to the escalation in the number of connected devices can lead to congestion in the network. The content distribution approach on the nodes is generalised and suitable for small networks. In the case of larger networks, an optimal approach is required to decide the optimal location to store the required content. However, a linear search approach is used to search (or lookup) the content in the assigned cache of the NDN node. In this work, the authors have combined the software‐defined networking (SDN) with the NDN approach to overcome the above‐highlighted challenge. Thus, the authors have designed an optimal content storage and indexing approach based on NDN‐SDN coalesce in the IoT ecosystem. The proposed approach includes different phases, (a) a hashing‐based content searching approach is formulated to reduce the look‐up time of the content, (b) a red‐black tree‐based content storage approach is introduced for optimal utilisation of the assigned cache memory of the different NDN nodes, and (c) SDN controller facilitates automated network management and helps to administer the network requirements centrally and locate the content accordingly. The proposed approach was validated through the simulation experiments concerning network delay, packet rate, throughput, and cache hit ratio. The results obtained show the effectiveness of the proposed approach.
Laboratory rotational spectroscopy of acrylamide and a search for acrylamide and propionamide toward Sgr B2(N) with ALMA
Authors: Kolesniková L. , Belloche A. , Koucký J. , Alonso E. R. , Garrod R. T. , Luková K. , Menten K. M. , Müller H. S. P. , Kania P. , Urban Š. 
Published: February 2022

Context. Numerous complex organic molecules have been detected in the universe and among them are amides, which are considered as prime models for species containing a peptide linkage. In its backbone, acrylamide (CH2CHC(O)NH2) bears not only the peptide bond, but also the vinyl functional group that is a common structural feature in many interstellar compounds. This makes acrylamide an interesting candidate for searches in the interstellar medium. In addition, a tentative detection of the related molecule propionamide (C2H5C(O)NH2) has been recently claimed toward Sgr B2(N).
Aims. The aim of this work is to extend the knowledge of the laboratory rotational spectrum of acrylamide to higher frequencies, which would make it possible to conduct a rigorous search for interstellar signatures of this amide using millimeter wave astronomy.
Methods. We measured and analyzed the rotational spectrum of acrylamide between 75 and 480 GHz. We searched for emission of acrylamide in the imaging spectral line survey ReMoCA performed with the Atacama Large Millimeter/submillimeter Array toward Sgr B2(N). We also searched for propionamide in the same source. The astronomical spectra were analyzed under the assumption of local thermodynamic equilibrium.
Results. We report accurate laboratory measurements and analyses of thousands of rotational transitions in the ground state and two excited vibrational states of the most stable syn form of acrylamide. In addition, we report an extensive set of rotational transitions for the less stable skew conformer. Tunneling through a low energy barrier between two symmetrically equivalent configurations has been revealed for this higher-energy species. Neither acrylamide nor propionamide were detected toward the two main hot molecular cores of Sgr B2(N). We did not detect propionamide either toward a position located to the east of the main hot core, thereby undermining the recent claim of its interstellar detection toward this position. We find that acrylamide and propionamide are at least 26 and 14 times less abundant, respectively, than acetamide toward the main hot core Sgr B2(N1S), and at least 6 and 3 times less abundant, respectively, than acetamide toward the secondary hot core Sgr B2(N2).
Conclusions. A comparison with results of astrochemical kinetics model for related species suggests that acrylamide may be a few hundred times less abundant than acetamide, corresponding to a value that is at least an order of magnitude lower than the observational upper limits. Propionamide may be as little as only a factor of two less abundant than the upper limit derived toward Sgr B2(N1S). Lastly, the spectroscopic data presented in this work will aid future searches of acrylamide in space.
Ultrasound of Small Nerves
Authors: Meng Stefan , Platzgummer Hannes , Loizides Alexander , Chang Ke-Vin , Gruber Hannes 
Published: February 2022

AbstractNerve ultrasound has become an integral part of the diagnostic workup of peripheral neuropathies. Especially in the examination of small nerves, ultrasound provides superior image quality by using high frequency transducers. For a selection of small nerves, this article summarizes the local anatomy and common pathologies and offers simple instructions for determining their location with ultrasound including some cases with pathologies. This selection of nerves comprises the great auricular nerve, the supraclavicular nerves, the suprascapular nerve, the medial antebrachial cutaneous nerve, the lateral antebrachial cutaneous nerve, the palmar cutaneous branch of the median nerve, the long thoracic nerve, the intercostobrachial nerve, the posterior cutaneous nerve, the infrapatellar branch of the saphenous nerve, the medial calcaneal nerve, and the deep peroneal nerve at the ankle. Following our recommendations, these nerves can be swiftly located and tracked along their course to the site of the pathology.
Kooperation und Konkurrenz – Eine Befragung ambulanter Hospizdienste zur Zusammenarbeit mit der SAPV
Authors: Heiß Kathrin , Jansky Maximiliane , Jaspers Birgit , Marx Gabriella , Schade Franziska , Nauck Friedemann , Banse Christian 
Published: February 2022

ZusammenfassungZiel Ziel der Befragung ist, die Auswirkungen der 2007 eingeführten Spezialisierten ambulanten Palliativversorgung (SAPV) auf die Arbeit ambulanter Hospizdienste (AHD) zu explorieren.Methodik AHD wurden 2015 zu Änderungen der Wahrnehmung von und Erwartungen an die Hospizarbeit sowie zur Kooperation mit SAPV-Teams befragt. Die Auswertung erfolgte statistisch-deskriptiv sowie zusammenfassend qualitativ inhaltsanalytisch (Freitexte).Ergebnisse 214 AHD für Erwachsene nahmen teil. Die Veränderung der Wahrnehmung von Hospizarbeit wurde mehrheitlich positiv bewertet. Fast alle AHD hatten überwiegend gute Erfahrungen in der Zusammenarbeit mit SAPV-Teams. SAPV verbessert die ambulante Palliativversorgung und verändert die Zusammenarbeit im Netzwerk, die Begleitungsanfragen, den Blick auf und die Erwartungen an AHD. Konkurrenz kann entstehen, wenn sich z. B. Aufgaben überschneiden oder sich der AHD verdrängt fühlt.Schlussfolgerungen Die enge Kooperation von Haupt- und Ehrenamt in der Hospiz- und Palliativversorgung kann auch im Rahmen der SAPV zu einer besseren Versorgung schwerkranker und sterbender Patientinnen und ihrer Angehörigen führen. Die Rolle und die Aufgaben ehrenamtlicher Hospizarbeit müssen in den Bildungs- und Qualifizierungsangeboten zur Palliativversorgung adäquat vermittelt werden. Die gegenseitige Wahrnehmung, Kooperation sowie mögliche Konkurrenzen sollten auch aus Sicht der SAPV-Teams, der Patienten und Angehörigen untersucht werden.
Serious Adverse Drug Reactions in Children and Adolescents Treated
On- and Off-Label with Antidepressants and Antipsychotics in Clinical
Practice
Authors: Egberts Karin M. , Gerlach Manfred , Correll Christoph U. , Plener Paul L. , Malzahn Uwe , Heuschmann Peter , Unterecker Stefan , Scherf-Clavel Maike , Rock Hans , Antony Gisela , Briegel Wolfgang , Fleischhaker Christian , Häge Alexander , Hellenschmidt Tobias , Imgart Harmut , Kaess Michael , Karwautz Andreas , Kölch Michael , Reitzle Karl , Renner Tobias , Reuter-Dang Su-Yin , Rexroth Christian , Schulte-Körne Gerd , Theisen Frank M. , Walitza Susanne , Wewetzer Christoph , Fekete Stefanie , Taurines Regina , Romanos Marcel 
Published: February 2022

Abstract
Introduction Despite the growing evidence base for psychotropic drug
treatment in pediatric patients, knowledge about the benefit-risk ratio in
clinical practice remains limited. The ‘Therapeutic Drug Monitoring
(TDM)-VIGIL’ study aimed to evaluate serious adverse drug reactions
(ADRs) in children and adolescents treated with antidepressants and/or
antipsychotics in approved (‘on-label’), and off-label use in
clinical practice.
Methods Psychiatric pediatric patients aged 6-18 years treated with
antidepressants and/or antipsychotics either on-label or off-label were
prospectively followed between October 2014 and December 2018 within a
multicenter trial. Follow-up included standardized assessments of response,
serious ADRs and therapeutic drug monitoring.
Results 710 youth (age=14.6±2.2 years,
female=66.6%) were observed for 5.5 months on average;
76.3% received antidepressants, 47.5% antipsychotics, and
25.2% both. Altogether, 55.2% of the treatment episodes with
antidepressants and 80.7% with antipsychotics were off-label. Serious
ADRs occurred in 8.3% (95%CI=6.4–10.6%)
of patients, mainly being psychiatric adverse reactions (77.4%),
predominantly suicidal ideation and behavior. The risk of serious ADRs was not
significantly different between patients using psychotropics off-label and
on-label (antidepressants: 8.1% vs. 11.3%, p=0.16;
antipsychotics: 8.7% vs 7.5%, p=0.67). Serious ADRs
occurred in 16.6% of patients who were suicidal at enrollment versus
5.6% of patients who were not suicidal (relative risk 3.0,
95%CI=1.9-4.9).
Conclusion Off-label use of antidepressants and antipsychotics in youth
was not a risk factor for the occurrence of serious ADRs in a closely monitored
clinical setting. Results from large naturalistic trials like ours can
contribute to bridging the gap between knowledge from randomized controlled
trials and real-world clinical settings.
A General Approach to Spirocyclic Piperidines via Castagnoli–Cushman Chemistry
Authors: Krasavin Mikhail , Peshkov Anatoly A. , Makhmet Azat , Bakulina Olga , Kanov Evgeny , Gainetdinov Raul , Peshkov Vsevolod A. , Dar’in Dmitry 
Published: February 2022

AbstractUnsaturated spirocyclic lactams stemming from a variant of the three-component Castagnoli–Cushman reaction successfully underwent hydrogenation to enable access to fully saturated spirocyclic lactams. The subsequent lactam reduction gave rise to 2-spiro piperidine building blocks. The latter can be further elaborated in compound libraries and, on their own, show propensity to activate trace amine-associated­ receptor 1 (TAAR1), an important target for CNS disease.
A Case Report of Idiopathic OAT Syndrome, Associated with Necrospermia and Hypospermia, Reversed with Individualized Homeopathy
Authors: Ramanan Vinitha Edavattath , Sathyanandhan Silpa 
Published: February 2022

Abstract
Background Oligo-astheno-teratozoospermia (OAT) syndrome is one of the causes of male infertility, characterized by a decreased number of sperms (oligospermia), poor sperm motility (asthenospermia), and abnormal sperm shape (teratospermia). In necrospermia, spermatozoa in the ejaculated semen are dead, and in hypospermia, semen volume is less than 2 mL. The present case may be unique because of the association of all these features together in a single patient.
Method This idiopathic case was treated, from November 2016 to April 2017 in the National Homeopathy Research Institute in Mental Health, with the homeopathic medicine Natrium muriaticum. The Modified Naranjo Criteria for Homeopathy (MONARCH) score was used to assess the likelihood of causal attribution of the clinical outcome to the homeopathic medicine.
Result By the third month of starting homeopathic treatment, there was a marked improvement in sperm count from 14.4 to 77.4 million, semen volume from 0.8 to 2.2 mL, and normal forms from 14 to 75%. His wife became pregnant by the 5th month and delivered a healthy baby girl at full term. A MONARCH score of +9/13 indicates a positive causal relationship between the medicine prescribed and the treatment outcome.
Conclusion The present case report suggests a positive effect of individualized homeopathic medicine in treating a rare presentation of male infertility due to OAT syndrome.
Endotherapy in Pancreatic Diseases
Authors: Jearth Vaneet , Rana Surinder S. 
Published: February 2022

AbstractInterventional endoscopy is now considered an effective minimally invasive treatment modality for the management of pancreatic diseases. It is important for the clinician to know the indications and contraindications as well as the timing of various endoscopic interventions. This will help in its safe and effective use and consequently decrease morbidity and mortality from various pancreatic diseases. This review will provide a broad overview of the indications, techniques, and outcomes of pancreatic endotherapy.
Botulinum Toxin Type A: Adverse Events and Management
Authors: Cavallini Maurizio , Papagni Marco , Lazzari Riccardo , Santorelli Adriano 
Published: February 2022

AbstractAesthetic medicine is witnessing an increasing exploitation of all the procedures. The demand has never been higher than it is today. The number of practitioners is also increasing year by year. Consequently complications and other kinds of related troubles and procedures are also rising. Never like today is fundamental, in case of troubles, how to properly manage with the most frequent issues. In aesthetic medicine field, botulinum toxin procedures are the safest. Lot of patients are worried about botulinum toxin despite the available scientific literature. Rare short-term complications are observed. In the most of cases, nothing severe occurs if the international recommendations and the most recent guidelines are closely followed, the majority of them are injection related. This study is a review of rare or common problems that can occur and how to manage or solve the situations.
Comparative Study of Fracture Outcome by Dynamic Compression Plating and Locking Compression Plating in Distal Tibial Fracture
Authors: Panigrahy Biswakesh , Behera Sanjib kumar , Hota Soubhagya Kumar , Nayak Ashok Kumar , Mohapatro Monalisa 
Published: February 2022

Abstract
Introduction Distal tibia fracture with or without fracture of fibula is very commonly encountered in young adults. The treatment protocol is mainly surgical with open reduction and internal fixation (ORIF) with plate and screw—contoured dynamic compression plating (DCP) or precontoured locking compression plating (LCP). In spite of advanced surgery, the outcome is not satisfactory with complications arising in 20 to 50% of patients. The purpose of this study was to determine the outcome and compare the two different modalities.
Materials and Methods The study includes 30 patients having distal tibial metaphyseal fracture without articular involvement treated with ORIF with plate and screw, contoured intraoperatively DCP and precontoured LCP in the Department of Orthopaedics. Patients were followed up for 12 to 24 months. Results were analyzed clinically (pain, alignment, range of motion, and complication) and radiologically. The patients were assessed according to time of full weight bearing, time of union of fracture, American Orthopaedic Foot and Ankle Society (AOFAS) score, and Foot Functionality Index score.
Results The time of full weight bearing and time of union were found to be statistically significant in DCP and LCP. According to the grading of AOFAS score, in DCP, excellent: 3 cases (20%), good: 6 cases (40%), and fair: 6 cases (40%). In LCP, excellent 3 cases (20%), good 8 cases (53.33%), fair 4 cases (26.66%) were observed.
Conclusion LCP offers stability with early weight bearing and quicker fracture healing. But both groups had the same score at the final follow-up.
Advantages of the Delayed–Immediate Microsurgical Breast Reconstruction: Extending the Choice
Authors: Pittelkow Eric , DeBrock Will , Christopher Laura , Mercho Raphael , Suh Lily Ji-Yun , Fisher Carla S. , Hartman Brett , Lester Mary , Hassanein Aladdin H. 
Published: February 2022

Abstract
Background Deep inferior epigastric perforator (DIEP) reconstruction can be performed in an immediate (at time of mastectomy), delayed–immediate (immediate tissue expander followed by staged DIEP), or delayed timing following mastectomy. Avoiding flap radiation is a known benefit of the delayed–immediate approach. The purpose of this study is to evaluate patients who chose DIEP flap as the reconstructive method during initial consultation and compared characteristics of surgery in relation to their final reconstructive choice.
Methods Consecutive patients having breast reconstruction from 2017 to 2019 were divided into three groups: immediate DIEP after mastectomy (Group I); delayed–immediate DIEP with tissue expander first followed by DIEP (Group II); and patients who initially chose delayed–immediate DIEP but later decided on implants for the second stage of reconstruction (Group III). Exclusion criteria were patients that had delayed DIEP (no immediate reconstruction) or had initially chose implant-based reconstruction.
Results The study included 59 patients. Unilateral free flaps in Group II had shorter operative times (318 minutes) compared with Group I unilateral free flaps (488 minutes) (p = 0.024). Eleven patients (30.6%) had prophylactic mastectomies in Group I compared with none in Group II (p = 0.004). Patients who had immediate tissue expansion frequently changed their mind from DIEP to implant for second stage reconstruction frequently (52.2%).
Conclusion Delayed–immediate DIEP reconstruction has several advantages over immediate DIEP flap including shorter free flap operative times. Patients commonly alter their preference for second stage reconstruction. A patient-centered advantage of delayed–immediate reconstruction is prolonging the time for patients to make their choice for the final reconstruction.
Effects of Inflammation on Hemostasis in Acutely Ill Patients with Liver Disease
Authors: Driever Ellen G. , Lisman Ton 
Published: February 2022

AbstractPatients with liver diseases are in a rebalanced state of hemostasis, due to simultaneous decline in pro- and anticoagulant factors. This balance seems to remain even in the sickest patients, but is less stable and might destabilize when patients develop disease complications. Patients with acute decompensation of cirrhosis, acute-on-chronic liver failure, or acute liver failure often develop complications associated with changes in the hemostatic system, such as systemic inflammation. Systemic inflammation causes hemostatic alterations by adhesion and aggregation of platelets, release of von Willebrand factor (VWF), enhanced expression of tissue factor, inhibition of natural anticoagulant pathways, and inhibition of fibrinolysis. Laboratory tests of hemostasis in acutely-ill liver patients may indicate a hypocoagulable state (decreased platelet count, prolongations in prothrombin time and activated partial thromboplastin time, decreased fibrinogen levels) due to decreased synthetic liver capacity or consumption, or a hypercoagulable state (increased VWF levels, hypofibrinolysis in global tests). Whether these changes are clinically relevant and should be corrected with antithrombotic drugs or blood products is incompletely understood. Inflammation and activation of coagulation may cause local ischemia, progression of liver disease, and multiorgan failure. Anti-inflammatory treatment in acutely-ill liver patients may be of potential interest to prevent thrombotic or bleeding complications and halt progression of liver disease.
Indocyanine Green Lymphography for Evaluation of Breast Lymphedema Secondary to Breast Cancer Treatments
Authors: Yamamoto Takumi , Yamamoto Nana 
Published: February 2022

Abstract
Background Although breast lymphedema (BL) significantly deteriorates quality of life (QOL) of breast cancer survivors, little is known and pathophysiological severity staging system is yet reported. This study aimed to evaluate usefulness of a novel BL severity staging system based on indocyanine green (ICG) lymphography findings.
Methods Breast cancer survivors with breast symptoms who underwent breast ICG lymphography were included. Breast ICG lymphography stage was determined based on visibility of linear pattern and extension of dermal backflow patterns. Prevalence of breast symptoms and lymphedema QOL score (LeQOLiS) was compared according to the stage.
Results Thirty-seven patients were included. Breast ICG lymphography stage included stage 0 in 11 (29.7%) cases, stage I in 3 (8.1%) cases, stage II in 11 (29.7%) cases, stage III in 6 (16.2%) cases, stage IV in 4 (10.8%) cases, and stage V in 2 (5.4%) cases. Higher ICG stages were associated with more frequent prevalence of breast swelling (p = 0.020), breast pain (p = 0.238), and breast cellulitis (p = 0.024), and with higher LeQOLiS (p < 0.001).
Conclusion ICG lymphography allows clear visualization of superficial lymph circulation in the breast. Higher breast ICG lymphography stages are associated with more frequent prevalence of BL-related symptoms and worse QOL.
A novel hybrid mode linear ultrasonic motor with double driving feet
Authors: Fu Daokuo , Fan Pingqing , Yuan Tao , Wang Yansong 
Published: February 2022

A novel standing wave linear ultrasonic motor with double driving feet based on longitudinal-bending coupling mode is designed in this study. The motor adopts the bonded-type structure, and four pieces of piezoelectric ceramics on a metal beam are divided into two groups. Two voltages with 90° phase difference are applied to two groups of Pb-based lanthanumdoped zirconate titanates ceramics, respectively. Then the first longitudinal and second bending modes generated are superimposed on the stator, which can produce elliptical motion trajectories on the driving feet. The excitation method and driving mechanism of the motor are illustrated in detail. A finite model of the stator is established in the ANSYS parametric design language interface, and the operating mode of the stator and motion trajectories on the driving feet are discussed. The prototype is fabricated, and its impedance characteristics and mechanical output performance are tested. The results show that the maximal no-load velocity of the motor is ∼147.78 mm/s under a voltage of 200 V and a preload of 3 N. The maximum thrust force is ∼1.1 N when the voltage and preload are 200 V and 6 N, respectively.