bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of telerehabilitation on quality of life, anxiety, and depression in children with cystic fibrosis and caregivers: A single‐blind randomized trial
Authors: Kenis‐Coskun Özge , Aksoy Ahsen N. , Kumaş Eda N. , Yılmaz Aybike , Güven Elifnur , Ayaz Hatice H. , Sözer Tuğçe , Ergenekon Almala P. , Karadağ‐Saygı Evrim 
Published: February 2022

AbstractBackgroundPostural and aerobic exercises are essential in rehabilitation in cystic fibrosis (CF). The aim of this study is to examine the effect of telerehabilitation on the quality of life, depression, and anxiety levels of children with CF and their caregivers' mood and anxiety levels.Materials and MethodsPatients between the ages of 6–13 with CF were randomized into two groups. Study group received an exercise program three times a week via Zoom for 12 weeks. Cystic Fibrosis Revised Questionnaire (CFQ‐R), Anxiety and Depression Scale in Children‐Revised (RCADS) were applied to the patients and State‐Trait Anxiety Scale (STAI) and Beck Depression Inventory (BDI) were applied to the caregivers in the beginning and at the end of the program. Patients' FEV1 levels and 6‐min walk tests were also measured.ResultsTwenty‐eight patient–caregiver dyads, 14 dyads in each group, completed the study. The initial mean RCADS‐Major depressive disorder score of the patients in the exercise group was 6.21 ± 3.11, and this value decreased to 3.92 ± 3.79 at the end of the study and was significantly better (p < 0.02). A similar significant change was observed when the RCADS‐generalized anxiety disorder score decreased from the initial mean level of 6.28 ± 2.81 to 3.42 ± 2.65 (p < 0.01). There were significant changes in improvement in the body image in telerehabilitation group. Similar significant changes were not observed in the control group. Caregivers' anxiety and depression levels did not change significantly.ConclusionA short‐term telerehabilitation program improved patients' anxiety and depression levels, body image, and functional status. However, caregiver anxiety and depression levels did not change significantly.
Facile Synthesis of FeOOH−Ni3S2 Nanosheet Arrays on Nickel Foam via Chemical Immersion toward Electrocatalytic Water Splitting
Authors: Yang Yaqian , Mao Han , Sun Kuishan , Ning Rui , Zheng Xiaohang , Sui Jiehe , Cai Wei 
Published: February 2022

AbstractElectrocatalytic water splitting is a useful and promising strategy to produce hydrogen, which is a sustainable and pollution‐free supply in the future. Herein, we design the FeOOH as an improved part to enhance the excellent water splitting catalytic activities of the Ni3S2, and the FeOOH−Ni3S2 shows remarkable electrocatalytic performance for OER and HER compared to the pristine Ni3S2 sample. Currently, we use a quick chemical immersion method to synthesize FeOOH on the surface of Ni3S2 nanosheets to form a FeOOH−Ni3S2 heterostructure. The FeOOH was formed as the dissolution process of Ni3S2 in Fe(NO3)3 solution. Our work opens up a quick, facile, and effective way to synthesize FeOOH and design high‐performance heterostructure electrocatalysts for energy conversion.
One‐pot Three‐component Solvent‐free Tandem Annulations for Synthesis of Tetrazolo[1,2‐a]pyrimidine and [1,2,4]triazolo[1,5‐a]pyrimidine
Authors: Datta Kumaresh , Mitra Bijeta , Sharma Biswajit Shil , Ghosh Pranab 
Published: February 2022

Abstractβ‐Cyclodextrin, a robust organocatalyst has been explored for the straightforward and facile synthesis of tetrazolo[1,2‐a]pyrimidine and [1,2,4]triazolo[1,5‐a]pyrimidine derivatives through one‐pot three‐component tandem annulations reaction under solvent‐free condition using aldehyde, active methylene compound and 5‐aminotetrazole or 3‐amino‐1,2,4‐triazole respectively. This greener chemical procedure has advantages such as shorter reaction time, absence of toxic and hazardous catalyst, chemicals and solvent, highly functional group tolerance, easy work up procedure and product separation.
Functionalized MCM‐41: Versatile Catalysts for Organic Transformations
Authors: Pasricha Sharda , Gahlot Pragya , Mittal Kavita , Rai Devansh , Avasthi Nishita , Kaur Harsimar , Rai Shruti 
Published: February 2022

AbstractFunctionalized MCM‐41 constitute a group of potent hybrid catalysts for organic reactions. Their pore size is large enough to house large substrate molecules, the large bulk of surface silanol groups helps in introduction of a variety of functionalities required for the catalytic action. The current review emphasizes the broad methodology for the synthesis of these catalysts, effect of functionalization on reaction parameters, stability, efficiency, selectivity, reusability along with limitations of these catalysts to organic transformations, from a green chemistry standpoint. Some selected mechanisms of catalytic action are also highlighted. The review demonstrates that surface functionalized MCM‐41 constitute innovative and need based catalyst systems that catalyze reactions like Sonogashira, Suzuki, Heck, Friedel Craft reaction, Aldol and Knoevenagel condensation etc. Several other reactions like oxidation, reduction, dehydration, esterification, epoxidation, C−S, C−N, C−O and S−S coupling as well as multicomponent synthesis of bioactive heterocycles have also been reported. It is hoped that this review will improve the understanding of scientific community on how these versatile catalysts operate and will provide opportunities to further enhance their utility for chemical industry.
Solvent‐Free Synthesis of Glycoside Annulated 1,2,3‐Triazole Based Dihydropyrimidinones using Copper Ferrite Nanomaterials as Heterogeneous Catalyst and DFT Studies
Authors: Bendi Anjaneyulu , Dharma Rao Gullapalli. B. , Sharma Nutan , Tomar Ravi , Singh Lakhwinder 
Published: February 2022

AbstractIn the present study, We have developed a facile and efficient method for the one‐pot five component synthesis of glycoside annulated 1,2,3‐triazole based dihydropyrimidinone derivatives using copper ferrite nanomaterials in the present work as heterogeneous catalyst. The quantum chemical investigations for the synthesized compounds have been carried out at the DFT/B3LYP/6‐31G(d) level of theory to predict the optimized geometry and different molecular properties. Frontier molecular orbitals, global reactivity descriptors, molecular electrostatic potential map, and thermodynamic parameters have also been reported at the same level of theory.
Study on Sensitivity and Drug Loading Characteristics of Graphene‐like BN Nanosheets to Indomethacin Based on DFT
Authors: Liu Yeshu , Zhang Guoying 
Published: February 2022

AbstractThe sensitivity and the drug loading characteristics of the doped BN nanosheet (BNNS) to indomethacin (INDO), a analgesic, anti‐inflammatory and antipyretic drug, were studied by using density functional theory. The adsorption energy calculated results show that the pristine BNNS can't be used to detect INDO, so that it can't be used as a potential efficient sensing materials to INDO. C, Si, Al, Ga doping enhances the absolute value of adsorption energy, and the recovery time is acceptable in practical application. All the elements studied (C, Si, Al, Ga, P, Cl) narrow the effective band gap, resulting in an increase of the electrical conductivity of INDO/BNNS complexes. These findings indicate the suitable doping improves the sensitivity of BNNS as sensing material to INDO, Si is the most efficient element. The INDO load on BNNS can be increased by the C, Si, Al, Ga doping. The sustained or controlled release of the INDO may be achieved by adjusting the doping of BNNS. Analysis of global reactivity descriptors show that the C, Si doping leads to the most reactive complexes. The solubility of INDO/doped BNNS complex can be modulated by the doping, and therefore BNNS can be as the carriers for poorly water‐soluble drugs. Comprehensive consideration of the adsorption energy, global reactivity descriptors and solubility, it is concluded that Si doped BNNS is most suitable as an INDO carrier.These results encourage a further investigation of BN nanosheet as a drug nanocarrier.
Synthesis of an Environmentally Friendly Boron Nitride/Dye Composite Photocatalytic Material and Study on Degradation Mechanism of Tetracycline Wastewater
Authors: Guo Yong , Ji Xin 
Published: February 2022

AbstractHerein, a boron nitride‐dye composite photocatalytic material is synthesized by a simple and environmentally friendly method. In this method, boron nitride (BN) is added to Methylene blue (MB), Congo red (CR), Rhodamine B (RhB), methyl orange (MO) solution respectively, the formed composites (BN‐RhB, BN‐MB, BN‐MO and BN‐CR) can further work as photocatalyst to degrade tetracycline (TC) under visible light irradiation. The degradation rate of TC are 278.5, 303.3, 89 and 115.5 times by BN‐RhB, BN‐MB, BN‐MO and BN‐CR higher than that of BN. This is from the sensitization of dyes for BN and these dyes have different absorption ranges for visible light. After the adsorption of BN for RhB‐MO, RhB‐CR, MB‐MO and MB‐CR mixed solutions, BN‐RhB‐MO, BN‐RhB‐CR, BN‐MB‐MO and BN‐MB‐CR composites are formed. Compared with BN, their photodegradation rate for TC are improved by about 102.75, 118, 388 and 460.75 times, respectively. The photodegradation rate of BN‐MB‐CR (k=0.01843) is better than that of BN‐MB (k=0.01213), being from that binary dyes are more conducive to improve the electron transfer efficiency than single dyes. The involved photo‐active species during photodegradation process and the photodegradation intermediate products of TC have detected as well. The photodegradation rate (k=0.01213) of BN‐MB for TC is also higher than that of g‐C3N4 (k=0.00599), g‐C3N4‐MB (k=0.01027), TiO2 (k=0.01061) and TiO2‐MB (k=0.01163). This work is helpful to develop an environment‐friendly water treatment material.
Solvent‐Free Synthesis of New Quinoline Derivatives via Eaton's Reagent Catalysed Friedländer Synthesis
Authors: Satheeshkumar Rajendran , Prasad Karnam Jayarampillai Rajendra , Wen‐Long Wang , Espinosa‐Bustos Christian , Salas Cristian O. 
Published: February 2022

AbstractAn interest for the development of new 2‐acetyl/propanoyl quinolines via Friedländer synthesis is one of the most studied synthetic approaches. Herein we report the use of a freshly prepared Eaton's reagent (phosphorus pentoxide in methanesulfonic acid) as catalyst without solvents to obtain quinoline derivatives. Eleven 2‐acetylquinolines were synthesized in high yields (85‐96 %) from symmetrical 1,2‐diketone, butan‐2,3‐dione with o‐aminoarylketones in the presence of Eaton's reagent. Subsequently, a novel regioselective solvent free reaction is reported for synthesis of o‐aminoarylketones with unsymmetrical 1,2‐diketone, pentan‐2,3‐dione, to yield different 2‐propanoylquinolines. Eaton's reagent performs a unique way of this reaction as a powerful desiccant, condensing, cyclizing and dehydrating agent. Among these advantages of Eaton's reagent was found as an inexpensive and easily accessible catalyst for the Friedländer synthesis.
Arginine‐Catalyzed Henry Reaction of α‐Keto Amides with Nitromethane on Water
Authors: Wu Chaofei , Hu Bolun , Liu Hongxin , Jiang Jun , Kim Jimin 
Published: February 2022

AbstractArginine‐catalyzed Henry reaction of α‐keto amides with nitromethane on water has been described, which provided nitroaldol adducts with excellent yields (up to 98 %). Importantly, a broad substrate scope (28 examples) was achieved under green and mild conditions.
Anchoring Ru/RuO2 Nanoparticles on Porous Carbon Shell as An Efficient Cathode Catalyst for Li‐CO2 Battery
Authors: Lian Zheng , Pei Ying , Ma Shiyu , Lu Youcai , Liu Qingchao 
Published: February 2022

AbstractRechargeable Li‐CO2 batteries have received a lot of attention due to their high energy density and ability to fix the greenhouse gas CO2. However, the lagged kinetics of CO2 reduction reaction (CRR) and CO2 evolution reaction (CER) has been restricting the development and application of Li‐CO2 batteries. Herein, ultrafine Ru/RuO2 nanoparticles anchored on hierarchical porous carbon shell (Ru/RuO2‐HPC) is designed and applied as an efficient cathode catalyst for Li‐CO2 batteries. The anchored Ru/RuO2 nanoparticles act as catalytic site not only accelerate CRR and CER kinetics but also tailor the reaction process of Li‐CO2 batteries, making discharge products are more susceptible to form sheet‐like by a surface‐adsorption pathway, which is easier to be decomposed in charge process. As a result, Li‐CO2 battery based on Ru/RuO2‐HPC cathode displays enhanced electrochemical performances, including high capacity, excellent round‐trip efficiency, and outstanding cycling stability.
Design Strategies of Gold Nanoparticles‐Based Biosensors Coupled with Hybridization Chain Reaction or Catalytic Hairpin Assembly
Authors: Ooi Jessica Sui Ying , New Siu Yee 
Published: February 2022

AbstractGold nanoparticles (AuNPs) have been a popular choice of biosensing material for decades. Given their remarkable physicochemical properties, they have been widely employed in different types of assays, including colorimetric, electrochemical, fluorescence and catalysis. With the emergence of enzyme‐free target amplification methods such as hybridization chain reaction (HCR) and catalytic hairpin assembly (CHA), integrating AuNPs with these DNA circuits provide a new paradigm in biosensing. This not only combines the advantages of each component, it also addresses limitations of certain design principles and allows improvement of the assay performance. This review aims to provide a comprehensive reference on different ways to construct AuNPs‐based biosensors assisted by HCR and CHA based on different detection principles. For each type of assay, the common design principle is presented and specific features are highlighted that may shed new light on the translation of AuNPs‐HCR or AuNPs‐CHA biosensors to biologically relevant applications.
How does a partner's acquisition affect the value of the firm's alliance with that partner?
Authors: Lavie Dovev , Lunnan Randi , Truong Binh Minh T. 
Published: February 2022

AbstractResearch SummaryHow does an acquisition initiated by a firm's alliance partner affect the value that the firm can create and capture from its alliance with that partner? We conjecture that the similarity between the businesses of the firm and its partner's acquisition target restricts the firm's ability to create and capture value from its alliance, whereas the complementarity between their businesses enhances the firm's gain from its alliance. We further expect relational embeddedness between the firm and its partner to mitigate the competitive tension associated with similarity while reinforcing synergies ascribed to complementarity. Our analysis of 361 firms and their 590 alliances with 91 partners that acquired 164 targets during 2000–2016 supports our predictions about business similarity and complementarity but refutes those concerning relational embeddedness.Managerial SummaryWhen a firm's partner engages in an acquisition, this can impact the value of their alliance. We show that when the acquired target competes with the firm, the value of the alliance declines. In turn, when the target and firm's businesses are complementary, the alliance creates more value. We also find that when the firm and the partner had extensive experience working together, this reinforces the negative effect of business similarity with the target, probably because of perceived betrayal and knowledge leakage. Joint experience also reduces the value of complementarity, likely due to the difficulty of modifying collaborative practices. We encourage managers to scrutinize their partners' corporate initiatives, reduce commitment when the partner acquires a competing target, and leverage new complementarities following the partner's acquisitions.
3D LiMn2O4 Thin Film Deposited by ALD: A Road toward High‐Capacity Electrode for 3D Li‐Ion Microbatteries
Authors: Hallot Maxime , Nikitin Viktor , Lebedev Oleg I. , Retoux Richard , Troadec David , De Andrade Vincent , Roussel Pascal , Lethien Christophe 
Published: February 2022

AbstractMiniaturized electronics suffer from a lack of energy autonomy. In that context, the fabrication of lithium‐ion solid‐state microbatteries with high performance is mandatory for powering the next generation of portable electronic devices. Here, the fabrication of a thin film positive electrode for 3D Li‐ion microbatteries made by the atomic layer deposition (ALD) method and in situ lithiation step is demonstrated. The 3D electrodes based on spinel LiMn2O4 films operate at high working potential (4.1 V vs Li/Li+) and are capable of delivering a remarkable surface capacity (≈180 μAh cm−2) at low C‐rate while maintaining more than 40 μAh cm−2 at C/2 (time constant = 2 h). Both the thickness of the electrode material and the 3D gain of the template are carefully tuned to maximize the electrode performance. Advanced characterization techniques such as transmission electron and X‐ray transmission microscopies are proposed as perfect tools to study the conformality of the deposited films and the interfaces between each layer: no interdiffusion or segregation are observed. This work represents a major issue towards the fabrication of 3D‐lithiated electrode by ALD—without any prelithiation step by electrochemical technique—making it an attractive solution for the fabrication of 3D Li‐ion solid‐state microbatteries with semiconductor processing methods.
Aggregation‐Dependent Dielectric Permittivity in 2D Molecular Crystals
Authors: Yang Yutian , Wang Yingying , Qiao Jingsi , Zhao Weiwei , Yu Yuanfang , Feng Shaopeng , An Xuhong , Zhang Jialin , Ji Wei , Wang Xinran , Lu Junpeng , Ni Zhenhua 
Published: February 2022

AbstractThe functionality of 2D molecular crystal‐based devices crucially depends on their intrinsic properties, such as molecular energy levels, light absorption efficiency, and dielectric permittivity, which are highly sensitive to molecular aggregation. Here, it is demonstrated that the dielectric permittivity of the 2,7‐dioctyl[1]benzothieno[3,2‐b][1]benzothiophene (C8‐BTBT) molecular crystals on monolayer WS2 substrates can be tuned from 4.62 in the wetting layer to 2.25 in the second layer. Its origin lies in the different molecular orientations in the wetting layer (lying‐down) and in the subsequently stacked layers (standing‐up), which lead to a positive Coulomb coupling (JCoup) value (H‐aggregation) and a negative JCoup value (J‐aggregation), respectively. Polarized optical contrast spectroscopy reveals that the permittivity of C8‐BTBT is anisotropic, and its direction is related to the underlying substrate. The study offers guidelines for future manipulation of the permittivity of 2D molecular crystals, which may promote their applications toward various electronic and optoelectronic devices.
Ultrasonographic features of atraumatic‐pathological subcapsular splenic haematomas in two dogs with confirmed lymphoma
Authors: Boozer Tara C. , Heng Hock Gan , Lim Chee Kin , Eichelberger Bunita , Childress Michael 
Published: February 2022

AbstractThis report describes the ultrasonographic features of splenic subcapsular haematoma in two dogs with lymphoma. One dog presented for suspicion of pancreatitis and the other for persistent lethargy; both dogs had peripheral lymphadenomegaly. Abdominal ultrasound showed an avascular, subcapsular, hypoechoic region along the parietal surface of the spleen. Both dogs underwent exploratory laparotomy, during which a splenectomy and biopsies of the liver and lymph nodes were performed. Lymphoma was diagnosed via histopathology in both dogs. Atraumatic‐pathological splenic subcapsular haematomas have been reported in humans with lymphoma, but this is the first known report in veterinary medicine in patients with lymphoma.
Analysis and Conceptualization of Healthcare Systems and Training in the Context of Technological Innovation and Personalization
Authors: Bogaert Brenda , Nova António Casa , Apay Serap Ejder , Özlü Zeynep Karaman , Melo Paulo , Pierron Jean-Philippe , Raposo Vítor , Sánchez-González Patricia 
Published: February 2022

AbstractThis chapter will analyse personalization within the context of technological innovation. It will first of all clarify the conceptual terms used in the debate, in particular patient, person-centered and people-centered care and their various uses and limitations. It will then focus on specific issues of personalization and technology in emerging areas, notably in interprofessional practices and in medical training. This will allow greater understanding of both the possibilities and emerging tensions in the integration of personalization and technological innovation in healthcare systems from the training stage to its integration in various professional cadres.
Probabilistic Modelling and Decision Support in Personalized Medicine
Authors: Javorník Michal , Dostál Otto , Roček Aleš 
Published: February 2022

AbstractThe concept of personalized medicine, often called the biggest revolution in medicine, is becoming an emerging practice. The article presents personalized medicine in a broader context as an interdisciplinary issue covering the current trends of information and communication technology in medicine, legal aspects, and probabilistic network modelling. Employing the concept of probabilistic network reasoning means extracting the meaningful knowledge, mathematizing it, incorporating the particular patient information and then using inference mechanisms of the created mathematical model for personalized decision support. Bayesian networks can serve as a multidimensional decision support framework representing the real-world medical domain. Their power, together with the possibilities of global sharing of necessary medical knowledge, represents a promising approach of extracting new, often hidden, knowledge about the given medical domain and thus opens up new ways of achieving the delivery of personalized medicine. Establishing patient diagnosis and treatment prognoses are the critical issues in personalized decision support. Mathematical modelling is beginning to play an irreplaceable role here.
Advancement of Efficiency Evaluation for Healthcare
Authors: Canolle Fabien , Antonić Darijana , Nova António Casa , Goncharuk Anatoliy , Melo Paulo , Raposo Vítor , Vinot Didier 
Published: February 2022

AbstractThe objective of this chapter is to provide conceptual understandings of evaluation methods for healthcare and concrete illustrations in order to take stock of the advancements and applications on the subject. The chapter is divided in four sections: the first one sets the stage at a European level by evaluating healthcare system performance; the second goes back to the fundamental principles of methods of evaluation for healthcare; the third one follows with illustrations of patient-centred and person-centred methods of evaluation; and the last part moves forward with a reflection on intangibles and a proposition for a method of observation.
Overview of the Artificial Intelligence Methods and Analysis of Their Application Potential
Authors: Kriksciuniene Dalia , Sakalauskas Virgilijus 
Published: February 2022

AbstractThe medical industry collects a huge amount of data, most of which is electronic health records. These data cannot be processed and analyzed using traditional statistical or data analysis methods because of the complexity and a volume of the data. So the knowledge discovery from raw clinical data is a big challenge for healthcare system. In this chapter we introduce the issue of data mining in healthcare, i.e. how to use the raw clinical data to ensure a systematic approach to health problems, highlight good practices, reveal inefficiencies, and improve healthcare efficiency. We identify the data sources used in healthcare, discuss its adequacy, interpretation, transformation and cleansing challenges. Also we consider the variety characteristics and specific capacities of methods, applied in the areas of data mining. Particular attention is paid to the diversity of Machine Learning and Artificial intelligence methods, analytical health data analysis models, its testing and evaluation capabilities.