bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiative Recombination Processes in Halide Perovskites Observed by Light Emission Voltage Modulated Spectroscopy
Authors: Sánchez Rafael S. , Villanueva‐Antolí Alexis , Bou Agustín , Ruiz‐Murillo Marta , Mora‐Seró Iván , Bisquert Juan 
Published: November 2022

AbstractThe kinetics of light emission in halide perovskite light‐emitting diodes (LEDs) and solar cells is composed of a radiative recombination of voltage‐injected carriers mediated by additional steps such as carrier trapping, redistribution of injected carriers, and photon recycling that affect the observed luminescence decays. These processes are investigated in high‐performance halide perovskite LEDs, with external quantum efficiency (EQE) and luminance values higher than 20% and 80 000 Cd m−2, by measuring the frequency‐resolved emitted light with respect to modulated voltage through a new methodology termed light emission voltage modulated spectroscopy (LEVS). The spectra are shown to provide detailed information on at least three different characteristic times. Essentially, new information is obtained with respect to the electrical method of impedance spectroscopy (IS), and overall, LEVS shows promise to capture internal kinetics that are difficult to be discerned by other techniques.
MoS2‐Mediated Epitaxial Plating of Zn Metal Anodes
Authors: Wang Yizhou , Xu Xiangming , Yin Jian , Huang Gang , Guo Tianchao , Tian Zhengnan , Alsaadi Rajeh , Zhu Yunpei , Alshareef Husam N. 
Published: November 2022

AbstractMetal‐based anodes (Li, Zn, etc.) are regarded as promising solutions for next‐generation advanced batteries due to their high theoretical specific capacities. However, most of these metal anodes suffer from dendrite growth, which severely restricts their practical applications. Recently, epitaxial anode metal deposition by choosing a suitable substrate has received tremendous attention as an effective strategy to suppress dendrites. However, the epitaxial relationship between plated metal and the substrate has been a subject of debate. Herein, large‐area, mono‐orientated 2D material (MoS2) is used, for the first time, to electrodeposit truly epitaxial Zn anodes. The continuous (without edges) mono‐orientated MoS2 films are shown to be an effective strategy for suppressing metal dendrites. In addition, the epitaxial nature of the electrodeposited Zn anode is proven by pole figure analysis, which provides the first demonstration of truly epitaxial Zn anode growth over large area as metal anode protection strategy through epitaxy.
Piezoelectric 1T Phase MoSe2 Nanoflowers and Crystallographically Textured Electrodes for Enhanced Low‐Temperature Zinc‐Ion Storage
Authors: Li Yihui , Dong Xingfang , Xu Zewen , Wang Menglei , Wang Ruofei , Xie Juan , Ding Yangjian , Su Pengcheng , Jiang Chengying , Zhang Xingmin , Wei Liyu , Li Jing‐Feng , Chu Zhaoqiang , Sun Jingyu , Huang Cheng 
Published: November 2022

AbstractTransition metal dichalcogenides (TMDs) are regarded as promising cathode materials for zinc‐ion storage owing to their large interlayer spacings. However, their capabilities are still limited by sluggish kinetics and inferior conductivities. In this study, a facile one‐pot solvothermal method is exploited to vertically plant piezoelectric 1T MoSe2 nanoflowers on carbon cloth (CC) to fabricate crystallographically textured electrodes. The self‐built‐in electric field owing to the intrinsic piezoelectricity during the intercalation/deintercalation processes can serve as an additional piezo‐electrochemical coupling accelerator to enhance the migration of Zn2+. Moreover, the expanded interlayer distance (9–10 Å), overall high hydrophilicity, and conductivity of the 1T phase MoSe2 also promoted the kinetics. These advantages endow the tailored 1T MoSe2/CC nanopiezocomposite with feasible Zn2+ diffusion and desirable electrochemical performances at room and low temperatures. Moreover, 1T MoSe2/CC‐based quasi‐solid‐state zinc‐ion batteries are constructed to evaluate the potential of the proposed material in low‐temperature flexible energy storage devices. This work expounds the positive effect of intrinsic piezoelectricity of TMDs on Zn2+ migration and further explores the availabilities of TMDs in low‐temperature wearable energy‐storage devices.
Bio‐Inspired Synthetic Hydrogen‐Bonded Organic Frameworks for Efficient Proton Conduction
Authors: Sun Yayong , Wei Jing , Fu Zhihua , Zhang Minyi , Zhao Sangen , Xu Gang , Li Chunsen , Zhang Jian , Zhou Tianhua 
Published: November 2022

AbstractHydrogen‐bonded organic frameworks (HOFs) are a rising class of promising proton‐conducting materials. However, they always suffer from the inherent contradiction between chemical stability and proton conduction. Herein, inspired by the self‐assembly of lipid bilayer membranes, a series of aminomethylphosphonic acid‐derived single‐component HOFs are successfully developed with different substituents attached to the phosphonate oxygen group. They remain highly stable in strong acid or alkaline water solutions for one month owing to the presence of charge‐assisted hydrogen bonds. Interestingly, in the absence of external proton carriers, the methyl‐substituted phosphonate‐based HOF exhibits a very high proton conductivity of up to 4.2 × 10−3 S cm−1under 80 °C and 98% relative humidity. This value is not only comparable to that of HOFs consisting of mixed ligands but also is the highest reported in single‐component HOFs. A combination of single‐crystal structure analysis and density functional theory calculations reveals that the high conductivity is attributed to the strengthened H‐bonding interactions between positively charged amines and negatively charged phosphonate groups in the channel of bio‐inspired HOFs. This finding demonstrates that the well‐defined molecular structure of proton conductors is of great importance in the precise understanding of the relationship between structure and property.
BSA‐AIE Nanoparticles with Boosted ROS Generation for Immunogenic Cell Death Immunotherapy of Multiple Myeloma
Authors: Liu Zhaoyun , Zhang Jingtian , Liu Hui , Shen Hongli , Meng Nanhao , Qi Xinwen , Ding Kai , Song Jia , Fu Rong , Ding Dan , Feng Guangxue 
Published: November 2022

AbstractThe main obstacle of multiple myeloma (MM) therapy is the compromised immune microenvironment, which leads to MM relapses and extramedullary disease progression. In this study, a novel strategy is reported of enhanced immunogenic cell death (ICD) immunotherapy with aggregation‐induced emission (AIE) photosensitizer‐loaded bovine serum albumin (BSA) nanoparticles (referred as BSA/TPA‐Erdn), which can activate T cells, convert the cold tumor to hot, and reverse T cell senescence to restore the immune microenvironment for MM treatment. Loading AIE photosensitizer into the hydrophobic domain of BSA proteins significantly immobilizes the molecular geometry, which massively increases reactive oxygen species (ROS) generation and elicits a promising ICD immune response. Employing a NOD‐SCID IL‐2receptor gamma null mice model with MM patients’ monocytes, it is shown that BSA/TPA‐Erdn can simulate human dentric cell maturation, activate functional T lymphocytes, and increase additional polarization and differentiation signals to deliver a promising immunotherapy performance. Intriguingly, for the first time, it is shown that BSA/TPA‐Erdn can greatly reverse T cell senescence, a main challenge in treating MM. Additionally, BSA/TPA‐Erdn can effectively recruit more functional T lymphocytes into MM tumor. As a consequence, BSA/TPA‐Erdn restores MM immune microenvironment and shows the best MM tumor eradication performance, which shall pave new insights for MM treatment in clinical practices.
Formation and Stabilization of NiOOH by Introducing α‐FeOOH in LDH: Composite Electrocatalyst for Oxygen Evolution and Urea Oxidation Reactions
Authors: Cai Minmin , Zhu Qian , Wang Xiyang , Shao Zhiyu , Yao Lu , Zeng Hui , Wu Xiaofeng , Chen Jun , Huang Keke , Feng Shouhua 
Published: November 2022

AbstractNiOOH is considered as the most active intermediate during electrochemical oxidation reaction, however, it is hard to directly synthesize due to high oxidation energy. Herein, theoretical calculations predict that α‐FeOOH enables a decline in formation energy and an improvement in stabilization of NiOOH in NiFe‐based layered double hydroxide (LDH). Inspiringly, a composite composed of α‐FeOOH and LDH is well‐designed and successfully fabricated in hydrothermal treatment by adding extra Fe3+ resource, and stable NiOOH is obtained by the following electro‐oxidation method. Benefiting from strong electron‐capturing capability of α‐FeOOH, it efficiently promotes charge redistribution around the Ni/Fe sites and activates Ni atoms of LDH, verified by X‐ray photoelectron spectra (XPS) and X‐ray absorption spectra (XAS). The d‐band center is optimized that balances the absorption and desorption energy, and thus Gibbs free energy barrier is lowered dramatically toward oxygen evolution reaction (OER) and urea oxidation reaction (UOR), and finally showing an outstanding overpotential of 195 mV and a potential of 1.35 V at 10 mA cm−2, respectively. This study provides a novel strategy to construct highly efficient catalysts via the introduction of a new phase for complex multiple‐electron reactions.
Acid waters in tank bromeliads: Causes and potential consequences
Authors: North Gretchen B. , Brinton Erin K. , Kho Tiffany L. , Fukui Kyle , Maharaj Franklin D. R. , Fung Adriana , Ranganath Mira , Shiina Joseph H. 
Published: November 2022

AbstractPremiseThe consequences of acidity for plant performance are profound, yet the prevalence and causes of low pH in bromeliad tank water are unknown despite its functional relevance to key members of many neotropical plant communities.MethodsWe investigated tank water pH for eight bromeliad species in the field and for the widely occurring Guzmania monostachia in varying light. We compared pH changes over time between plant and artificial tanks containing a solution combined from several plants. Aquaporin transcripts were measured for field plants at two levels of pH. We investigated relationships between pH, leaf hydraulic conductance, and CO2 concentration in greenhouse plants and tested proton pump activity using a stimulator and inhibitor.ResultsMean tank water pH for the eight species was 4.7 ± 0.06 and was lower for G. monostachia in higher light. The pH of the solution in artificial tanks, unlike in plants, did not decrease over time. Aquaporin transcription was higher for plants with lower pH, but leaf hydraulic conductance did not differ, suggesting that the pH did not influence water uptake. Tank pH and CO2 concentration were inversely related. Fusicoccin enhanced a decrease in tank pH, whereas orthovanadate did not.ConclusionsGuzmania monostachia acidified its tank water via leaf proton pumps, which appeared responsive to light. Low pH increased aquaporin transcripts but did not influence leaf hydraulic conductance, hence may be more relevant to nutrient uptake.
A bump in the node: The hydraulic implications of rhizomatous growth
Authors: Suissa Jacob S. , Agbleke Andrews A. , Friedman William E. 
Published: November 2022

AbstractPremiseRhizomatous growth characterizes numerous taxa among vascular plants. While abundant information exists on nutrient sharing and demography, the question of how these metameric organisms move water through their bodies remains largely unstudied. Moreover, we lack an understanding of the evolutionary implications of rhizomatous growth across vascular plants. Here, we examined these questions by investigating how rhizomatous growth and vascular construction affect whole‐plant hydraulic function.MethodsIn five terrestrial fern species with diverse vascular construction, we used microcomputed tomography and bright‐field microscopy to examine vascular construction across nodes along the rhizome. These data were integrated with measurements of leaf stomatal conductance under rooted and uprooted conditions to relate vascular patterning and hydraulic architecture to leaf water status.ResultsSimilar to phytomers of woody seed plants, nodal regions in rhizomatous ferns are areas of hydraulic resistance. While water is shared along the rhizomes of these investigated species, hydraulic conductivity drops at nodes and stomatal conductance declines when nodes were locally uprooted. Together, our data suggest that nodes are chokepoints in axial water movement along the rhizome.ConclusionsNodal chokepoints decrease hydraulic integration between phytomers. At the same time, chokepoints may act as “safety valves”, hydraulically localizing each phytomer—potentially decreasing embolism and pathogen spread. This suggests a potential trade‐off in the principal construction of the fern rhizome. Moreover, we propose that shoot‐borne roots (homorhizy) and the prostrate habit of rhizomatous ferns decrease the hydraulic and structural burdens that upright plants typically incur. The absence of these hydraulic and structural demands may be one reason ferns (and many rhizomatous plants) lack, or have minimally developed, secondary xylem.
Diagnostic yield of clinical exome sequencing in adulthood in medical genetics clinics
Authors: Mainali Apurba , Athey Taryn , Bahl Shalini , Hung Clara , Caluseriu Oana , Chan Alicia , Eaton Alison , Ghai Shailly Jain , Kannu Peter , MacPherson Melissa , Niederhoffer Karen Y. , Siriwardena Komudi , Mercimek‐Andrews Saadet 
Published: November 2022

AbstractClinical exome sequencing (ES) is the most comprehensive genomic test to identify underlying genetic diseases in Canada. We performed this retrospective cohort study to investigate the diagnostic yield of clinical ES in adulthood. Inclusion criteria were: (1) Adult patients ≥18 years old; (2) Patients underwent clinical ES between January 1 and December 31, 2021; (3) Patients were seen in the Department of Medical Genetics. We reviewed patient charts. We applied American College of Medical Genetics and Genomics and the Association for Molecular Pathology variant classification guidelines for interpretation of variants. Non‐parametric Fisher's exact statistical test was used. Seventy‐seven patients underwent clinical ES. Fourteen different genetic diseases were confirmed in 15 patients: FBXO11, MYH7, MED13L, NSD2, ANKRD11 (n = 2), SHANK3, RHOBTB2, CDKL5, TRIO, TCF4, SCN1, SMAD3, POGZ, and EIF2B3 diseases. The diagnostic yield of clinical ES was 19.5%. Patients with a genetic diagnosis had a significantly higher frequency of neurodevelopmental disorders than those with no genetic diagnosis (p = 0.00339). The diagnostic yield of clinical ES was the highest in patients with seizures (35.7%), and with progressive neurodegenerative diseases (33.3%). Clinical ES is a helpful genomic test to provide genetic diagnoses to the patients who are referred to medical genetic clinics due to suspected genetic diseases in adulthood to end their diagnostic odyssey. Targeted next generation sequencing panels for specific phenotypes may decrease the cost of genomic test in adulthood.
A Highly Accurate pH Detection Method for Sweat Analysis using a Printed 96‐Microwell Colorimetric Sensor Array
Authors: Sasaki Yui , Lyu Xiaojun , Minami Tsuyoshi 
Published: November 2022

AbstractThis work reports on a facile 96‐microwell paper‐based colorimetric sensor array device (PCSAD) for highly accurate pH detection toward sweat analysis. Although a pH test strip has been widely used to easily visualize pH conditions with naked eyes, its accuracy to guarantee below the decimal point in pH changes has still been a concern. In contrast, the PCSAD could detect slight pH changes because of abundant chemical information by the array design. The color gradients on the PCSAD upon changing pH conditions can be rapidly recorded by a flatbed scanner. The captured digital images of the PCSAD were treated with imaging analysis, followed by extraction of color intensities for inset data. By employing the partially overlapped detectable pH ranges of pH indicators, seamless inset data was obtained. Therefore, the PCSAD successfully discriminated against slight changes in pH conditions in human sweat with high accuracy by pattern recognition methods.
An unusual theropod specimen from the late Maastrichtian of New Jersey
Authors: Gallagher William B. 
Published: November 2022

AbstractA set of fragmentary bones excavated from the Inversand Company Pit at Sewell, Gloucester County, NJ, contains portions of broken hollow femur bone that display unusual interior structure. Two hypotheses are considered; (1) the lumina represents the distinctive physical features of medullary bone as described by M. Schweitzer in a series of papers; or (2) the interior bone growth is a pathology. The specimen is attributed to the Theropoda on the basis of the possession of a pneumatic foramen in one of the bones. This specimen is from the upper part of the New Egypt Formation, just below the K/T boundary in the base of the overlying Hornerstown Formation. This stratigraphic horizon is the same as the type specimen of Dryptosaurus aquiluguis which was excavated from a marl pit nearby.
Immunosensor for human IgE detection using electrochemical redox cycling with ferrocene‐mixed self‐assembled monolayers modified Au electrode
Authors: Kim Ki Jun , Song Yesol , Park Seungyoung , Oh Seung Jun , Kwon Seong Jung 
Published: November 2022

AbstractThe concentration of human immunoglobulin E (IgE) in blood is an indicator for diagnosing an allergy. For detecting human IgE by an electrochemical immunosensor, redox mediator molecules were modified on a gold electrode using thiolated organic molecules, which can form self‐assembled monolayers on the electrode surface. Ferrocene was used as a redox mediator, and the current signal was amplified via redox cycling using 4‐aminophenol. Measurements were obtained after the immobilization of the target‐captured antibody, target human IgE, biotin‐conjugated secondary antibody, and avidin alkaline phosphatase in a sandwich‐type immunosensor configuration. The prepared immunosensor exhibited a limit of detection of 1 IU/mL and dynamic range of 3–30 IU/mL.
Ultrasound‐mediated delivery of flexibility‐tunable polymer drug conjugates for treating glioblastoma
Authors: Sun Tao , Krishnan Vinu , Pan Daniel C. , Filippov Sergey K. , Ravid Sagi , Sarode Apoorva , Kim Jayoung , Zhang Yongzhi , Power Chanikarn , Aday Sezin , Guo Junling , Karp Jeffrey M. , McDannold Nathan J. , Mitragotri Samir S. 
Published: November 2022

AbstractEffective chemotherapy delivery for glioblastoma multiforme (GBM) is limited by drug transport across the blood–brain barrier and poor efficacy of single agents. Polymer–drug conjugates can be used to deliver drug combinations with a ratiometric dosing. However, the behaviors and effectiveness of this system have never been well investigated in GBM models. Here, we report flexible conjugates of hyaluronic acid (HA) with camptothecin (CPT) and doxorubicin (DOX) delivered into the brain using focused ultrasound (FUS). In vitro toxicity assays reveal that DOX‐CPT exhibited synergistic action against GBM in a ratio‐dependent manner when delivered as HA conjugates. FUS is employed to improve penetration of DOX‐HA‐CPT conjugates into the brain in vivo in a murine GBM model. Small‐angle x‐ray scattering characterizations of the conjugates show that the DOX:CPT ratio affects the polymer chain flexibility. Conjugates with the highest flexibility yield the highest efficacy in treating mouse GBM in vivo. Our results demonstrate the association of FUS‐enhanced delivery of combination chemotherapy and the drug‐ratio‐dependent flexibility of the HA conjugates. Drug ratio in the polymer nanocomplex may thus be employed as a key factor to modulate FUS drug delivery efficiency via controlling the polymer flexibility. Our characterizations also highlight the significance of understanding the flexibility of drug carriers in ultrasound‐mediated drug delivery systems.
Two Teflon granulomas of the nasopharynx and paravertebral space mimicking a neoplasm
Authors: Kamp Frederieke , Storck Claudio 
Published: November 2022

AbstractTeflon has been proved to be able to extravasate and infiltrate into soft tissue to form an inflammatory giant‐cell foreign‐body reaction, a so‐called Teflon granuloma. We present a rare case report of a patient with two Teflon granulomas of the head and neck, who were first interpreted as a neoplasm.
Harnessing the CRISPR‐Cas13d System for Protein Detection by Dual‐Aptamer‐Based Transcription Amplification
Authors: Feng Zhi‐Yuan , Liu Ran , Li Xiang , Zhang Jingjing 
Published: November 2022

AbstractCRISPR‐based biosensing technology has been emerging as a revolutionary diagnostic tool for many disease‐related biomarkers. In particular, RspCas13d, a newly identified RNA‐guided Cas13d ribonuclease derived from Ruminococcus sp., has shown great promise for accurate and sensitive detection of RNA due to its RNA sequence‐specific recognition and robust collateral trans‐cleavage activity. However, its diagnostic utility is limited to detecting nucleic‐acid‐related biomarkers. To address this limitation, herein we present a proof‐of‐concept demonstration of a target‐responsive CRISPR‐Cas13d sensing system for protein biomarkers. This system was rationally designed by integrating a dual‐aptamer‐based transcription amplification strategy with CRISPR‐Cas13d (DATAS‐Cas13d), in which the protein binding initiates in‐vitro RNA transcription followed by the activation of RspCas13d. Using a short fluorescent ssRNA as the signal reporter and cardiac troponin I (cTnI) as the model analyte, the DATAS‐Cas13d system showed a wide linear range, low detection limit, and high specificity for the detection of cTnI in buffer and human serum. Thanks to the facile integration of various bioreceptors into the DATAS‐Cas13d system, the method could be adapted to detecting a broad range of clinically relevant protein biomarkers, and thus broaden the medical applications of Cas13d‐based diagnostics.
Single‐Particle Measurements: A Powerful Method for Investigating Electrochemical Reactions
Authors: Li Xu , Li Na , Yang Le , Chen Hao‐Sen , Song Wei‐Li 
Published: November 2022

AbstractThe relationship between interface structure (e. g., the facet of the solid phase and the configuration of solvation) and the reactivity of the corresponding electrode is a critical issue in electrochemistry. Compared to macroscopic electrode measurements, electrochemical methods established on the single‐particle scale have advantages in establishing the structure‐property relationship. In recent years, great achievements have been made in electrochemical energy storage and electrocatalysis that allow the evolution and kinetics of electrodes to be understood by employing single‐particle measurements. This concept aims to provide an overview of the update of single‐particle measurements in related electrochemical processes. Furthermore, the challenges and prospects for the development and application of single‐particle measurements are also discussed.