bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the state and development trends of the region based on indicators of economic potential (based on the materials of the Novosibirsk region)
Authors: Сигунова Т.А. 
Published: March 2022

В статье осуществляется анализ и оценка показателей социально-экономического развития Новосибирской области. Выявлено, что Новосибирская область в настоящее время не реализует накопленный инновационно-научный потенциал, что отражается в относительно низких значениях индикаторов экономического развития. Автором предложена методика оценки экономического потенциала региона на основе использования индикаторов материально-технического, финансово-экономического и инновационно-институционального потенциалов. Предложенная методика, апробированная на примере Новосибирской области, позволяет комплексно оценивать состояние развития региона; выявлять факторы, сдерживающие развитие области, и выявлять тенденции экономического роста. Значения предложенных индикаторов экономического потенциала Новосибирской области сравниваются со средними показателями по России с целью получения объективной оценки состояния развития региона. Анализ тенденций развития Новосибирской области показал, что оценка индикаторов экономического развития постепенно приближается к средней по России, однако регион имеет неиспользованный научный потенциал, эффективная реализация которого позволит продемонстрировать более высокую конкурентоспособность на региональном, страновом и национальном уровне.
The article analyzes and evaluates the indicators of socio-economic development of the Novosibirsk region. It is revealed that the Novosibirsk Region currently does not realize the accumulated innovation and scientific potential, which is reflected in the relatively low values of economic development indicators. The author proposes a methodology for assessing the economic potential of the region based on the use of indicators of material and technical, financial and economic, innovative and institutional potentials. The proposed methodology, tested on the example of the Novosibirsk region, allows us to comprehensively assess the state of development of the region; to identify factors hindering the development of the region, and to identify trends in economic growth. The values of the proposed indicators of the economic potential of the Novosibirsk region are compared with the average indicators for Russia in order to obtain an objective assessment of the state of development of the region. The analysis of trends in the development of the Novosibirsk region showed that the assessment of economic development indicators is gradually approaching the average for Russia, but the region has untapped scientific potential, the effective implementation of which will allow demonstrating higher competitiveness at the regional, country and national levels.
Formation of the industrial policy mechanisms in the conditions of industry 4.0 development
Authors: Юдин Н.Н. , Абрашкин М.С. 
Published: March 2022

В статье уточнены механизмы формирования промышленной политики в условиях развития Индустрии 4.0 в России. Методом логико-абстрактного моделирования доказано, что имеющаяся организационно-управленческая структура промышленности не отвечает в полной мере интересам его опережающего развития. Предложен механизм формирования промышленной политики, основанный на трёх последовательных компонентах, необходимых для перехода к Индустрии 4.0. Данный механизм основан на внутриотраслевой и межотраслевой цифровой интеграции хозяйствующих субъектов, развитии частно-государственного партнёрства. Проведен анализ показателей эффективности промышленной политики с точки зрения перехода к Индустрии 4.0.
The article clarifies the mechanisms for the formation of industrial policy in the context of the development of Industry 4.0 in Russia. It has been proved by the method of logical-abstract modeling that the existing organizational and management structure of the industry does not fully meet the interests of its advanced development. A mechanism for the formation of industrial policy is proposed, based on three sequential components necessary for the transition to Industry 4.0. This mechanism is based on intra-sectoral and inter-sectoral digital integration of business entities, the development of public-private partnerships. The analysis of indicators of the effectiveness of industrial policy from the point of view of the transition to Industry 4.0.
Applied mathematical tools of interregional statistics of economic crime
Authors: Ляпин А.Е. 
Published: March 2022

В представляемой научной статье нами сконцентрировано внимание на актуальной проблеме комплексного статистического исследования экономической безопасности государства и субъектов рыночной экономики, а также угроз, которые несет собой преступность налоговой и коррупционной направленности. Для исследования такого объекта в научной статье задействован весь статистический инструментарий, представленный методами, классификациями, показателями, специальными приемами, которые на сегодняшний день имеются в багаже статистической науки и практики.
In this scientific article, we focus on the actual problem of a comprehensive statistical study of the economic security of the state and market economy entities, as well as the threats posed by tax and corruption-related crime. To study such an object, the scientific article uses all the statistical tools presented by methods, classifications, indicators, and special techniques that are currently available in the baggage of statistical science and practice.
Features of calculation and problems of administration of value added tax in the implementation of foreign trade activities
Authors: Костин А.А. , Дудкина Д.А. 
Published: March 2022

В статье рассмотрены особенности исчисления НДС при совершении торговых операций на внешнем рынке товаров, как с точки зрения их осуществления, так и администрирования. Многосторонний анализ особенностей позволил выявить сложности на конкретных этапах возникновения обязанности уплаты НДС. Сделаны выводы и сформулированы предложения решения существующих проблем.
The article discusses the features of calculating the value added tax when performing trade operations on the foreign market of goods, both from the point of view of their implementation and administration. A comprehensive analysis of the features allowed us to identify difficulties at specific stages of the emergence of the obligation to pay VAT. Conclusions are drawn and proposals for solving existing problems are formulated.
Quality assessment of digital processing of images obtained by aerial photography with unmanned aerial vehicles
Authors: Арешев Д.С. 
Published: March 2022

Аэрофотосъемка и воздушная фотограмметрия с использованием беспилотных летательных аппаратов обеспечивают качество фотографий, не уступающее качеству, достигаемому при наземной фотосъемке, вместе с тем, использование беспилотных летательных аппаратов предоставляет более широкие возможности для формирования трехмерных изображений различных объектов, по сравнению с наземной фотосъемкой. Цифровая обработка видеоинформации, полученной при помощи фотокамеры, установленной на беспилотном летательном аппарате, требует проведения большого объема вычислений, поэтому актуальной задачей является оценка качества получаемого изображения для оптимизации алгоритмов обработки.
Aerial photography and aerial photogrammetry with unmanned aerial vehicles provides photo quality not worse than the quality оf ground photography, however unmanned aerial vehicles provides more potential for getting 3D images of various objects than ground photography. Digital processing of video information obtained with a camera mounted on an unmanned aerial vehicle requires a great amount of calculations therefore quality assessment of the resulting images is an actual task to optimize processing algorithms.
4-Hydroxypyrones	and	Related	Templates	as	Nonpeptidic	HIV Protease Inhibitors
Authors: Homines K.R. , Chrusciel R.A. 
Published: March 2022

Abstract:
One promising therapeutic approach for the treatment of HIV infection is inhibition of the viral protease. Although a number of HIV protease inhibitors have been developed, many of the more potent compounds are peptide-derived structures. Since clinical use of such compounds is often hindered by poor pharmacokinetics and lengthy syntheses, interest in small, nonpeptidic HIV protease inhibitors has been growing. One of the most encouraging recent developments in the search for these structures is the advent of a new class of competitive inhibitors, the
4-hydroxypyrones. Screening efforts by researchers at The Upjohn Company and Parke-Davis Pharmaceutical Research independently identified the 4-hydroxycoumarins and the 4- hydroxypyrones as lead structures with weak inhibitory activity. Subsequent co-crystallization of these lead compounds with HIV protease showed that the 4-hydroxypyrone ring was functioning as the pharmacophore. These x-ray crystal structures also provided the basis for extensive structure-based drug design work, which led to the discovery of several potent inhibitors in both the 4-hydroxycoumarin and 4-hydroxypyrone classes. In addition, three new classes of derivatives were designed: the tetronic acids, the cycloalkypyranones, and the dihydropyrones. To date, .two compounds from The Upjohn Company have entered the clinic for phase I evaluation, a 4-hydroxypyrone and a cyclooctylpyranone. In preclinical evaluation, these candidates, which are both readily accessible synthetically, demonstrated not only promising antiviral activity, but also good pharmacokinetic profiles in rats and dogs.
The Nucleophilic Addition/Eiectrophilic Ring Closure Route to Bio-Active Heterocycles
Authors: Perlmutter Patrick 
Published: March 2022

Abstract:
Many bio-active compounds contain one or more saturated or partially saturated heterocycles. Most of these contain one or more stereo­ centres. As a result any attempts to synthesize these compounds must take full account of the stereochemistry. In this article a new approach to the stereoselective synthesis of heterocycles is reviewed. The emphasis is on oxygen-containing heterocycles. The approach involves a sequence of a
nucleophilic addition reaction followed by an electrophilic ring closure. Examples are given of the
stereoselective synthesis of the heterocyclic subunits of macrolide and polyether antibiotics, y­butyrolactone autoregulators, marine polyether toxins and C-glycosides.
Diversified Applications of Self-assembled Nanocluster Delivery Systems- A State-ofthe-
art Review
Authors: Shende Pravin , Rodrigues Bernice , Govardhane Sharayu 
Published: March 2022

Background:
For the nanoparticulate system and the transportation of cellular elements for the fabrication
of microelectronic devices, self-assembled nanoclusters arrange the components into an organized structure.
Nanoclusters reduce transcytosis and increase endocytosis in intestinal mucin to strengthen the retrograde
pathway that helps for delivery of actives to the Golgi apparatus.

Objectives:
This review article focuses on the self-assembled nanoclusters for cellular transportation, applications
of self-assembled structures in the delivery of essential elements like using a peptide in targeted and
stimuli-responsive drug delivery systems, and self-assembly of tocopherol nanoclusters that promote vitamin E
delivery across the endothelial barrier.

Methods:
Current innovation in the self-assembly of peptides includes the formation of nanostructures like vesicles,
fibers, and rod-coil in various applications of wound healing, tissue engineering, atherosclerosis treatment,
sensing heavy metals from biological and environmental samples, and advanced drug delivery.

Results:
Self-assembled biodegradable nanoclusters are used as biomimetic structures for a synergistic effect.
For temperature-triggered drug release nanoclusters, modifications in preparation methods, such as the inclusion
of a copolymer, are made.

Conclusion:
Green synthesis of nanoclusters, nanocluster-based biosensors, and artificial intelligence are future
concepts in the manufacturing and prevention of toxicity in humans.
Overexpression of Ribosomal Protein S6 Kinase A4 (RPS6KA4) Predicts a
Poor Prognosis in Hepatocellular Carcinoma Patients: A Study Based on
TCGA Samples
Authors: Wang Chen , Lu Yu , Ren Xuechen , Zhou Chengliang , Chen Hao , Fan Yong 
Published: March 2022

Aim:
This study aims to comprehensively analyse the Ribosomal Protein S6 Kinase A4
(RPS6KA4) and determine the prognostic value for hepatocellular carcinoma (HCC).

Background:
Liver cancer is a common type of tumor worldwide, and HCC accounts for about 75
to 85% of all primary liver cancer cases. The Ribosomal S6 protein kinases (RSK) family plays an
important regulatory role in cell growth, movement, survival, and proliferation.

Methods:
We collected the expression and clinicopathological features of RPS6KA4 in The Cancer
Genome Atlas (TCGA) cohort and evaluated the prognostic value of RPS6KA4 in HCC. Gene Ontology
(GO)/ Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment
Analysis (GSEA) were performed to determine the enrichment pathways of RPS6KA4. Correlation
between RPS6KA4 expression and immune infiltration was analyzed. Protein-protein interaction
(PPI) network analysis was performed to screen hub genes.

Results:
RPS6KA4 overexpression is statistically significant in HCC relative to normal tissues (P <
0.001). Increased expression of RPS6KA4 is associated with higher T stage (p=0.021), pathological
stage (p=0.006), α-fetoprotein (AFP) value (p=0.026), and vascular invasion (p=0.023) of HCC.
Overexpression of RPS6KA4 predicted worse overall survival (OS, P=0.002), disease-specific survival
(DSS, P=0.012), and progress-free interval (PFI, P=0.031) for HCC. Univariate/multivariate
Cox regression analysis confirmed that RPS6KA4 was an independent risk factor for HCC
(P=0.002 in univariate analysis; P=0.014 in multivariate analysis). GO/KEGG analysis and GSEA
analysis suggest that RPS6KA4 plays a precancer role in HCC through epigenetics, cell adhesion,
tumor-driven GTPase pathways, infection-related carcinogenesis, and adaptive immunity. Immune
infiltration analysis confirmed the strong negative relationship between RPS6KA4 and B cells,
CD4+ T cells, macrophages, neutrophils, as well as dendritic cells. Protein-protein interactions
(PPI) analysis and hub gene identification revealed the cancer-promoting effects of RPS6KA4 related
to RSKs, AP-2, clathrin, and MAPK/ ERK pathways.

Conclusion:
RPS6KA4 is a potentially valuable molecule for understanding HCC tumorigenesis.
Increased RPS6KA4 might be a promising prognostic factor for low HCC survival.
Systematic Analysis of the Expression Profile and Prognostic Significance
of the IGF2BP Family in Lung Adenocarcinoma
Authors: Zhou Zimo , Zhu Tiantong , Chen Senxiang , Qin Sen , Huang Ying , Liu Da 
Published: March 2022

Background:
Lung adenocarcinoma (LUAD), the most common type of lung cancer associated
with poor prognosis, has become a major health problem. IGF2BPs are types of N6-methyladenosine
reader proteins, comprising IGF2BP1, IGF2BP2, and IGF2BP3, that promote LUAD progression. However,
the expression profiles and prognostic value of IGF2BPs in LUAD remain unclear.

Objective:
This study aimed to analyze the expression profiles and prognostic significance of the
IGF2BP family in lung adenocarcinoma.

Methods:
In this study, we included tissue data of LUAD patients and normal or para-carcinoma from
the TCGA database and the GTEx project. Using survival analysis, Kaplan-Meier curves, and Cox proportional
hazards model, we analyzed the expression profiles and prognostic significance of the IGF2BP
family.

Results:
Patients with high expression levels of IGF2BPs showed a significant association with poor
overall survival (p < 0.05). Moreover, the somatic mutation rates of IGF2BP1, IGF2BP2, and IGF2BP3
were determined as 2.65, 1.59, and 1.76%, respectively, by investigating the genetic mutation. In addition,
there were significant associations between TMB and IGF2BP family expression profiles, which
positively correlated with the expression of PD-1 (p < 0.05). Cox proportional hazard model for LUAD
showed the risk score for IGF2BP1, p-TNM stage, and so forth, all independent prognostic indicators for
LUAD patients. Finally, the co-expression genes were obtained to build a PPI network and analyze the
hub genes of the IGF2BP family.

Conclusion:
Our study provides further insights into the role of the IGF2BP family in LUAD and identifies
10 genes that may be associated with IGF2BPs in LUAD patients.
Design, Synthesis, and Evaluation of Isoindoline Derivatives as New Antidepressant Agents
Authors: Sun Ai-Ling , Wang Chao-Chao , Zhou Hao , Lang Yi-Fei , Fu Shu-Yue , Liu Ren-Min , Lei Kang 
Published: March 2022

Background:Isoindoline derivatives exhibit a wide range of biological activities and have attracted considerable attention. However, few studies have been conducted on their antidepressant activity.Objective:Here, we designed and synthesized a series of isoindoline derivatives and studied their antidepressant activities.Method:Forced swimming test (FST) and tail suspension test (TST) were used to evaluate the antidepressant activity of the target compounds. The most active compound was used to evaluate the exploratory activity of the animals by the open-field test. 5-HT concentration was estimated to evaluate if the compound has an effect on the mice brain by using ELISA. The biological activities of the compounds were verified by molecular docking studies. The pharmacokinetic properties of the target compounds were predicted by Discovery Studio (DS) 2020.Results:The results of the pharmacological experiments showed that most isoindoline derivatives exhibited significant antidepressant activity. Among these compounds, compound 4j showed the highest antidepressant activity. The results of the measurement of 5-HT levels in the brains of mice indicate that the antidepressant activity of isoindoline derivatives may be mediated by elevated 5-HT levels. Compound 4j was used in molecular docking experiments to simulate the possible interaction of these compounds with the 5-HT1A receptor. The results demonstrated that compound 4j had a significant interaction with amino acids around the active site of the 5-HT1A receptor in the homology model.Conclusion:Isoindoline derivatives synthesized in this study have a significant antidepressant activity. These findings can be useful in the design and synthesis of novel antidepressants.
AA, ACR, and ACN Polymer (Synthetic Thickener) Formulation:
Utilisation of Reactive Printing of Cotton
Authors: Madhu Chintan R. 
Published: March 2022

Objective:
In this study, a synthetic thickener was synthesized by polymerizing
acrylic acid, acrylonitrile, and acrylamide.

Methods:
The characterisation of the thickener was confirmed with Fourier transform infrared
spectral data, rheology, and viscosity. The formulated thickener was utilised to prepare
reactive printing paste in different concentrations, printed on cotton. The same procedure
was undertaken for the study with guar gum and sodium alginate.

Results:
The characteristics of prints such as K/S value, strength, fastness to washing,
dry/wet rubbing, and light were assessed.

Conclusion:
The highest K/S value and excellent fastness properties were found in the
samples printed using formulated polymer.
Condensation Reactions of Aromatic Aldehydes with Active Methylene
Compounds: The Beneficial Sinergy of Alkaline Ionic Liquid in One Pot
Synthesis
Authors: Bankar Swapnil R. 
Published: March 2022

Background:
In recent times, there has been on-going interest in developing convenient
and environmentally friendly synthetic methods in organic chemistry. The use of ionic liquid catalysts
in organic synthesis is a developing area that allows reactions to be run at low temperatures and
without solvents. Literature overview revealed that room temperature supported ionic liquid catalysis
is a developing field in catalytic science with huge application in organic synthesis. Hence in this
current article, our focus is on the one-pot synthesis of arylidene derivatives with the use of ([bmim]
OH) ionic liquid.

Objectives:
We describe here the use of an ionic liquid catalyst, 1-n-butyl-3-methylimidazolium hydroxide,
[bmim] OH), in the convenient one pot synthesis of arylidene derivatives by the reaction of
the active methylene compound, malononitrile, with pyrazole aromatic aldehydes under microwave
irradiation.

Methods:
The functionalized ionic liquid, 1-n-butyl-3-methylimidazolium hydroxide ([bmim] OH),
catalyzed Knoevenagel condensation reactions of pyrazole aromatic aldehydes with active methylene
compound malononitrile carried out under microwave irradiation. The reaction progress was monitored
by thin layer chromatography and the synthesized compounds were further characterized by
NMR spectroscopy.

Results:
This proposed work demonstrates the utility of the use of the ionic liquid catalyst [bmim]
OH, in the suitable, high yield (80-95%) microwave assisted reactions of pyrazole aromatic aldehydes
with the active methylene compound, malononitrile.

Conclusion:
An eco-friendly synthesis of pyrazole derivatives has been demonstrated using ([bmim]
OH) ionic liquid as a catalyst for the Knoevenagel condensation reactions of pyrazole aromatic aldehydes
and malononitrile with microwave irradiation. The advantages of this green method are its
convenience, mild reaction conditions, and high product yields (80-95%).
تقييم الاداء المالي لعينة من المصارف العاملة في اقليم كوردستان-العراق للمدة (2009 -2019)
Authors: Ahmed Younis Ali , Zahir Wrya Muhammad 
Published: March 2022

تعد عملية تقييم الأداء بأنها من الأهداف الرئيسية للمؤسسة، ويمثل الأداء أحد العوامل والمقومات الرئيسة التي تعتمد عليها المؤسسة لقياس النجاح أو الفشل. يشكل التحليل المالي لأرصدة المصارف انعكاساً وبشكل واضح لحقيقة المركز المالي لتلك المصارف، حيث يسهم تحليل النشاط المصرفي المالي في بيان نقاط الضعف في اداء المصارف و بناء نموذج ملائم لتطوير الأداء المصرفي في المصارف عموما والمصارف على وجه التحديد، يسعى البحث إلى تحقيق هدف تقييم الأداء المالي لعينة من المصارف العاملة في إقليم كوردستان- العراق للمدة (2009 – 2019) من خلال الاعتماد على أهم المعايير والمؤشرات الرئيسة في تقييم الأداء المالي ومن أجل تحقيق هدف البحث، فقد تم الإعتماد على المنهج الوصفي - التحليلي المقارن استنادا إلى الاساليب القياسية المتقدمة و التحليل المالي و الاقتصادي اعتماداً على البيانات التي تم الحصول عليها من التقارير السنوية الصادرة عن المصارف (عينة البحث). وقد تبين من البحث والتحليل ومن خلال المؤشرات التي تم استخدامها ان هناك تقلبات كبيرة في البيانات المالية السنوية للمصارف و ان مستوى الاداء لم يكن مستقرا في المصارف بين فترة واخرى وذلك بسبب الاوضاع المالية والسياسية غير المستقرة وكذلك ضعف السياسات المتبعة لبعض المصارف في بعض السنوات اضافة إلى ذلك و من خلال الجانب التطبيقي فان البحث يكشف ايضا أنه حسب مؤشر نسبة هامش صافي الربح (المصرف المتحد للأستثمار في المرتبة الأولى و مصرف الاستثمار العراقي في المرتبة الثانية و مصرف الأهلي العراقي في المرتبة الثالثة)، بينما تختلف هذه الترتيبات حسب نوع المؤشرات من ذلك يجب على تلك المصارف ضرورة عمل على تحقيق الاستقرار في النشاط المصرفي والأداء المالي خلال رفع القدرة التنافسية من جهة و العمل على رفع مستوى الكفاءات الاستثمارية المباشرة وغير المباشرة.