bluuebunny/crossref_metadata_2025_split huggingface dataset:
New radiographic classification of endovascular recanalization of symptomatic non-acute carotid artery occlusion
Authors: Yan Wentao , Li Xiuzhen , Guo Wei , Liu Jiachun , Yan Changxiang 
Published: March 2022

Abstract
Purpose: To propose a new imaging classification based on cerebral angiography to determine the segment and length of occlusion and the condition of the proximal and distal lumen of the occluded segment.Methods: This retrospective study included patients with non-acute carotid artery occlusion (NACAO) who visited XXX Hospital (01/2017-12/2020). The lesions were classified according to the segment and length of carotid artery occlusion and the proximal and distal lumen of the occluded segment. Results: Type IV is not recommended for endovascular recanalization, and patients with types I (10/24, 41.7%), II (7/24, 29.2%), and III (7/24, 29.2%) were included. The recanalization success rate was 87.5% (21/24; Type I, 10/10; Type II, 7/7; Type III, 4/7; P=0.017). The incidence of perioperative complications was 25.0% (6/24; Type I, 0/10; Type II, 2/7; Type III, 4/7; P=0.038). The re-occlusion rate was not significantly different among the three groups (P=0.284). The average modified Rankin Scale (mRS) score in the success group was lower than before operation (P=0.012), but not in the failure group (P=0.317). Conclusion: The new classification based on cerebral angiography is helpful to screen patients with drug-refractory NACAO with a high success rate and low complications of intra-tube recanalization.
Modern approaches to the treatment of peritoneal carcinomatosis from gastric cancer (literature review)
Authors: Solodkiy V. A. , Fomin D. K. , Goncharov S. V. , Kukushkina S. A. 
Published: March 2022

Background. Gastric cancer (GS ) is one of the most common and deadly cancers in Russia and worldwide. In 40 % of cases, GC is diagnosed at an advanced stage, thus increasing the risk of distant metastasis. Peritoneal carcinomatosis from GC is one of the most common pathways of dissemination, with a median survival time of less than 6 months.Aim. To study various modern approaches to the treatment of peritoneal carcinomatosis in gastric cancer.Material and Methods. Literature search was performed in Medline, Cochrane Library, Elibrary, Scopus, PubMed systems.Results. Currently, there is a wide variety of approaches to combined modality treatment of metastatic GC . Various options of cytoreductive surgeries are being developed. These surgeries are combined with neoadjuvant/adjuvant, intra-abdominal chemotherapy and radiation therapy. However, the results of studies on improving survival and reducing recurrence in patients with advanced GC are contradictory. Currently, patients with morphologically and cytologically confirmed free cancer cells in the peritoneal lavage without visualized intra-abdominal metastatic lesions are the most controversial group for the choice of appropriate treatment. Gastric cancer recurrence in these patients occurs within 2 years. In addition, the 5-year survival rate in patients with the presence of free cancer cells in peritoneal washings amounts for 2 %. One of the most effective experimental treatments for peritoneal carcinomatosis in gastric and ovarian cancers was intra-abdominal radionuclide therapy using colloidal198Au. The main advantage of the method was the complete cessation of the formation of effusion into the abdominal cavity in ascites forms of the disease. However, due to the high intestinal toxicity of radioactive gold tracer and radiation exposure to patients and medical staff, further work was stopped.Conclusion. Thus, the search of the most effective tactic of peritoneal carcinomatosis treatment in patients with advanced GC is still in progress.
Levels of endothelin-1 and high molecular weight kininogen in blood of breast cancer patients after SARS-coV-2 infection
Authors: Frantsiyants E. M. , Surikova E. I. , Vladimirova L. Yu. , Myagkova V. S. , Katelnitskaya O. V. , Pogorelova Yu. A. , Lysenko I. B. , Engibaryan M. A. 
Published: March 2022

The aim. To analyze the blood levels of endothelin-1 (ET -1) and high molecular weight kininogen (HMWK) in patients with breast cancer (BC) previously infected with the new coronavirus.Material and methods. The study group included 20 patients with stage II -IV BC (invasive carcinoma). All patients were receiving chemotherapy at the time of their SA RS-CoV-2 infection. The comparison group included 19 women without breast cancer, who were matched for age. All women of both groups had an RT-PC R confirmed SA RS-Cov-2 infection. Blood levels of ET -1 and HMWK were measured by ELISA 3–10 weeks after the positive antigen test results. The control group included 10 women of the same age without cancer and without CO VID -19 symptoms and anti-SA RS-CoV-2 antibodies.Results. The ET -1 levels in the comparison group were within the reference range, while HMWK levels were significantly higher than those in breast cancer patients. In BC patients with lung metastases, the ET -1 levels were higher than those in the comparison group patients, while in others (no history of lung metastases, with mild infection course or pneumonia), the ET -1 levels were similar to those in the comparison and control groups. The HMWK levels in the study and comparison groups were significantly higher than those in controls. Among BC patients, there were women who had significantly higher ET -1 and HMWK levels compared to the reference levels, and the majority of these patients had lung metastases and previous CO VID -19 pneumonia.Conclusion. The measurement of HMWK blood levels demonstrated that the plasma contact activation system and the kallikrein-kinin system were active for a long period after the infection both in BC patients and in women without cancer. A high level of ET -1, the endothelial dysfunction marker, persisted for a long time in some BC patients. Our results were consistent with results of other studies supporting the hypothesis that SA RS-CoV-2 virus infection is a systemic vascular disease with long-term consequences, and its mechanisms require further study.
Bronchoplatic surgery in the treatment of patients with nonsmall cell lung cancer
Authors: Aksarin A. A. , Ter-Ovanesov M. D. , Kopeyka S. M. 
Published: March 2022

Aim. To study the effect of organ-preserving bronchoplastic surgery on long-term treatment outcomes of patients with non-small cell lung cancer (NSCLC ).Material and Methods. The long-term results of surgical treatment of 740 patients with stage I–III NSCLC , who were treated in Ugra from 2002 to 2015, were analyzed. Lobectomy and bilobectomy were performed in 477 patients, and pneumonectomy was performed in 263 patients. Thirty-two patients underwent bronchoplastic lobectomy and bilobectomy. Intraoperative pathological frozen sections of lymph nodes (# 12) of the remaining lobe of the lung were examined in all patients. If metastases in these lymph nodes were not detected, we performed bronchoplastic lobectomy. If metastases in lymph nodes of the remaining lobe were detected, we performed pneumonectomy. The median age of the patients (only male patients) was 55.3 ± 9.9 years. In 19 (59.4 %) patients, sleeve resections were performed on the right side and in 13 (40.6 %) patients, these resections were performed on the left side. There were 15 bronchoplastic lobectomies of type A, 9 of type B, 4 of type C, and 4 of type D. Sleeve resection of the pulmonary artery was performed in 4 patients. In 16 cases (50.0 %), there were no regional metastases (pN0). In 10 (31.3 %) cases, there was pN1, in six – pN2 (18.7 %).Results. There were no cases of postoperative death. Late complications (asymptomatic bronchial stenosis) occurred in 3 (9.4 %) patients. Long-term treatment outcomes were better in patients who underwent organ-preserving bronchoplastic surgery than in patients who underwent pneumonectomy. Median survival was 66 months after bronchoplastic lobectomies and 34 months after pneumonectomies (p=0.01). The 5- and 10-year survival rates in patients who underwent bronchoplastic lobectomies were 52.9 % and 36.2 %, respectively. The corresponding values in patients who underwent pneumonectomies were 38.0 % and 31.9 %, respectively.Conclusion. Organ-preserving bronchoplastic surgery compared to pneumonectomy does not worsen long-term outcomes in patients with NSCLC .
Complete Response Evaluation of Locally Advanced Rectal Cancer to
Neoadjuvant Chemoradiotherapy Using Textural Features Obtained from
T2 Weighted Imaging and ADC Maps
Authors: Kartal Merve Gulbiz , Azamat Sena , Karaman Şule , Azamat Ibrahim Fethi , Ertaş Gokhan , Kulle Cemil Burak , Keskin Metin , Sakin Rabia Nergiz Dağoğlu , Bakır Barış , Oral Ethem Nezih 
Published: March 2022

Background:
The prediction of pathological responses for locally advanced rectal cancer
using magnetic resonance imaging (MRI) after neoadjuvant chemoradiotherapy (CRT) is a challenging
task for radiologists, as residual tumor cells can be mistaken for fibrosis. Texture analysis of MR images
has been proposed to understand the underlying pathology.

Objective:
This study aimed to assess the responses of lesions to CRT in patients with locally advanced
rectal cancer using the first-order textural features of MRI T2-weighted imaging (T2-WI) and apparent
diffusion coefficient (ADC) maps.

Methods:
Forty-four patients with locally advanced rectal cancer (median age: 57 years) who underwent
MRI before and after CRT were enrolled in this retrospective study. The first-order textural parameters
of tumors on T2-WI and ADC maps were extracted. The textural features of lesions in pathologic
complete responders were compared to partial responders using Student’s t- or Mann–Whitney U
tests. A comparison of textural features before and after CRT for each group was performed using the
Wilcoxon rank sum test. Receiver operating characteristic curves were calculated to detect the diagnostic
performance of the ADC.

Results:
Of the 44 patients evaluated, 22 (50%) were placed in a partial response group and 50% were
placed in a complete response group. The ADC changes of the complete responders were statistically
more significant than those of the partial responders (P = 0.002). Pathologic total response was predicted
with an ADC cut-off of 1310 x 10-6 mm2/s, with a sensitivity of 72%, a specificity of 77%, and
an accuracy of 78.1% after neoadjuvant CRT. The skewness of the T2-WI before and after neoadjuvant
CRT showed a significant difference in the complete response group compared to the partial response
group (P = 0.001 for complete responders vs. P = 0.482 for partial responders). Also, relative T2-WI
signal intensity in the complete response group was statistically lower than that of the partial response
group after neoadjuvant CRT (P = 0.006).

Conclusion:
As a result of the conversion of tumor cells to fibrosis, the skewness of the T2-WI before
and after neoadjuvant CRT was statistically different in the complete response group compared to the
partial response group, and the complete response group showed statistically lower relative T2-WI
signal intensity than the partial response group after neoadjuvant CRT. Additionally, the ADC cut-off
value of 1310 × 10-6 mm2/s could be used as a marker for a complete response along with absolute
ADC value changes within this dataset.
Gene Therapy for Neuropsychiatric Disorders: Potential Targets and Tools
Authors: Lotfi Marzieh , Tambuwala Murtaza M. , Shahcheraghi Seyed H. , Ayatollahi Jamshid , Aljabali Alaa A.A. , Al-Zoubi Mazhar S. , Panda Pritam K. , Mishra Vijay , Satija Saurabh , Charbe Nitin B. , Serrano-Aroca Ángel , Bahar Bojlul , Takayama Kazuo , Goyal Rohit , Bhatia Amit , Almutary Abdulmajeed G. , Alnuqaydan Abdullah M. , Mishra Yachana , Negi Poonam , Courtney Aaron , McCarron Paul A. , Bakshi Hamid A. 
Published: March 2022

Abstract:Neuropsychiatric disorders that affect the central nervous system cause considerable pressures on the health care system and have a substantial economic burden on modern societies. The present treatments based on available drugs are mostly ineffective and often costly. The molecular process of neuropsychiatric disorders is closely connected to modifying the genetic structures inherited or caused by damage, toxic chemicals, and some current diseases. Gene therapy is presently an experimental concept for neurological disorders. Clinical applications endeavor to alleviate the symptoms, reduce disease progression, and repair defective genes. Implementing gene therapy in inherited and acquired neurological illnesses entails the integration of several scientific disciplines, including virology, neurology, neurosurgery, molecular genetics, and immunology. Genetic manipulation has the power to minimize or cure illness by inducing genetic alterations at endogenous loci. Gene therapy that involves treating the disease by deleting, silencing, or editing defective genes and delivering genetic material to produce therapeutic molecules has excellent potential as a novel approach for treating neuropsychiatric disorders. With the recent advances in gene selection and vector design quality in targeted treatments, gene therapy could be an effective approach. This review article will investigate and report the newest and the most critical molecules and factors in neuropsychiatric disorder gene therapy. Different genome editing techniques available will be evaluated, and the review will highlight preclinical research of genome editing for neuropsychiatric disorders while also evaluating current limitations and potential strategies to overcome genome editing advancements.
Permissioned Blockchain-based Trustworthy Edge Storage Scheme for
Smart Grid
Authors: Li Yuancheng , Liu Yan , Zhang Yan , Liu Haiqing 
Published: March 2022

Background:
With the development of technologies such as the Internet of Things (IoT)
and cloud/edge computing, a large number of edge devices in the smart grid accomplish information
interconnection and generate massive amounts of data. On the one hand, smart grids need to obtain
a large amount of grid data from edge terminal devices. On the other hand, edge computing also
brings some security threats. Therefore, edge data security faces major challenges.

Objective:
In order to ensure the security of data in the edge computing environment of the smart
grid, we propose an edge data storage scheme (BlockSE) for the smart grid edge computing environment.

Method:
BlockSE combines permissioned blockchain and smart contract technology to achieve
secure storage of data on edge. We adapted ring signature technology to achieve privacy preserving
of participating nodes. To allocate the storage resources of edge servers fairly and transparently, we
designed a storage resource allocation algorithm based on the smart contract, whereby edge devices
can obtain storage resources fairly according to demand.

Results:
Simulation experiments were performed; the results show the effectiveness of the proposed
BlockSE scheme.

Conclusion:
This paper focused on data security in the smart grid's edge computing environment
and proposed a secure storage scheme for edge data based on permissioned blockchain. The evaluation
shows the safety, effectiveness, and practicability of the proposed BlockSE scheme.
Sociālās apdrošināšanas politiskie aspekti: Rīgas Arodbiedrību centrālbiroja darbība slimokasēs 20. gadsimta 20. gadu otrajā pusē
Authors: Plakane Guna 
Published: March 2022

Sociālā apdrošināšana Latvijā 20. gadsimta 20. gados bija nozīmīga valsts labklājības politikas daļa. Viens no tās būtiskākajiem elementiem bija slimokases, kuru darbībā iesaistījās dažādi politiskie spēki. Raksta mērķis ir izpētīt sociālās apdrošināšanas politiskos aspektus, izmantojot Rīgas Arodbiedrību centrālbiroja darbības piemēru slimokasēs 20. gadsimta 20. gadu otrajā pusē. Rakstā sniegts sociālās apdrošināšanas un slimokasu politizācijas svarīgāko aspektu vispārīgs raksturojums un, balstoties uz līdz šim pētniecībā neizmantotiem avotiem par centrālbiroja darbību slimokasēs, analizētas tā politiskās nostādnes, darbības koordinācijas mehānismi un galvenās darbības iezīmes.
[RETRACTED]Karakteristik Gangguan Tidur pada Usia Produktif dan Usia Pertengahan
Authors: Yahman Soleh Amini , Purwanto Setiyo , Anganti Nisa Rachmah Nur 
Published: March 2022

The article titled “Karakteristik Gangguan Tidur pada Usia Produktif dan Usia Pertengahan” ([version 1; peer review: 1 not approved] F1000Research 2019, 8: 396 http://10.23917/humaniora.v22i2.13555) has been retracted by F1000Research on the grounds of scientific misconduct. On submission to F1000Research, all manuscripts undergo plagiarism checks as standard—this is detailed in our Originality policies. Upon submission, authors are also required to declare that the article is not under consideration or review by another publisher. At this stage in the publication process, our plagiarism detection software did not identify any significant duplication of text. On investigation, the extent of overlap between these two publications was substantial, and this was deemed a case of duplicate publication. Duplicate publication is a major ethical issue and, as a member of the Committee on Publication Ethics (COPE) and a follower of the Jurnal Penelitian Humaniora (JPH) recommendations, F1000Research takes such matters seriously. In response to our concerns, corresponding author Soleh Amini acknowledged that publication misconduct has taken place and has been informed that, due to the extent and nature of duplication between the articles published in F1000Research and IOP, F1000Research will retract the article and publish a linked retraction notice. In line with COPE guidelines, F1000Research has informed the Publisher of IOP Conference Series about this issue, and our final decision has been communicated to all authors and their respective institutions.
Problems of the generation through the prism of Serhii Zhadan's lyrical vision (based on the collection “Ballads about war and reconstruction”)
Authors: Maltsev Valentyn , Tsivinska Yuliia 
Published: March 2022

The aim of the study is to identify the problems of the generation of the 1990s, raised in the poetry collection of S. Zhadan “Ballads of war and reconstruction” and to clarify the specifics of the author's vision of their causes and impact on society. Research methods: cultural-historical, biographical, comparative. Scientific novelty. For the first time, the article analyzes the author's artistic vision of the crisis of the generation of the 90s, acute social problems, the causes of which are caused by the socio-political circumstances of the last century, and also highlights the key thematic features of the collection. Conclusions. The collection “Ballads of war and reconstruction” is the author's revelation about his attitude to the past. S. Zhadan does not hide anything and not afraid to be incomprehensible. The poet does not disguise the truth and does not try to smooth it out. The collection contains works that raise important problems of the last century, including war, its consequences and influence on the formation of consciousness of subsequent generations, the destruction of cultural figures by the Soviet regime, population migration and criticism of the political system. The author draws attention to details that often contradict the subject and the dissonance “high / low” becomes noticeable. But this technique only exacerbates the problem, causes even more attention and reflection. In general S. Zhadan's collection testifies to the development of the author's style at different levels as well as continues the main motives of his literary work and shows the peculiarities of artistic vision. Prospects for further research of S. Zhadan's poetic work are seen in the observation of the development and in the detailed analysis of the problems and topics of the author's collections of poems as well as in the study of emphony, stylistic and artistic means in his texts, features of versification etc.
The genre of ballad in cinematic discourse (the cinema ballad “Wild flowers“ (2000) by the Czech director F. A. Brabec)
Authors: Nikoriak Natalia , Sazhyna Alla 
Published: March 2022

The objective of the article is to analyze the specifics of cinematic interpretation of the ballads from the collection “A Bouquet of Czech Folk Legends” (1853), written by a famous Czech writer and folklorist K.J. Erben, in the film by F.A. Brabec “Wild Flowers” (2000) within the concept of genre continuity. Methods of research: comparative method, method of intermedial and receptive analysis. Novelty of research: the issue of intermedially oriented genre continuity is investigated for the first time within the discourse of Ukrainian Literary Criticism. Conclusions. The cinematic text of the director F. Brabec fully preserves and conveys all the basic codes of the genre of literary ballad: the preciseness of the narrative, the depth of disclosure of life, the severity of the situations described, the limited personosphere, the dramatic and unexpected denouement. Therefore, the above texts are perceived as short “concentrated tragedies”. In addition, the director broadens the main text of the ballads, supplementing each plot with a backstory; he actively applies montage and film trails, as well as reduces time parameters, fragments and dialogues, at the same time preserving the main content of the original. Particular emphasis in the research has been laid on the fact that each ballad, reproduced by means of cinematic language (“Bouquet”, “The Water-Goblin”, “The Wedding Shirts”, “Lady Midday”, “The Golden Spinning Wheel”, “Daughter’s Curse”, “Christmas Eve”), is presented as a completed independent text and is regarded as an indispensable part of the holistic author’s concept.
PENGARUH JOB ENRICHMENT, REWARD DAN TEAMWORK TERHADAP EMPLOYEE ENGAGEMENT PADA PT NUSANTARA BERLIAN MOTOR
Authors: Wahyono Teguh 
Published: March 2022

This study aims to determine the effect of Job Enrichment, Reward and Teamwork on Employee Engagement at PT Nusantara Berlian Motor. The sample in this study were all employees of PT Nusantara Berlian Motor, totaling 45 employees. This research was conducted from July to November 2020. Sources of data were collected through questionnaires. This study uses quantitative data with multiple linear regression analysis model. The results showed that Job Enrichment and Reward had a positive and significant effect on Employee Engagement at PT Nusantara Berlian Motor partially. Teamwork does not have a significant effect on Employee Engagement at PT Nusantara Berlian Motor partially. Job Enrichment, Reward, and Teamwork simultaneously have a positive and significant effect on Employee Engagement at PT Nusantara Berlian Motor. Keywords: Job Enrichment, Reward, Teamwork, Employee Engagement
PERANCANGAN FIREWALL FILTERING DAN MANAJEMEN BANDWIDTH MENGGUNAKAN ROUTER MIKROTIK PADA JARINGAN KOMPUTER SMA NEGERI 1 SEPUTIH BANYAK LAMPUNG TENGAH
Authors: Apriyanto Dika , Sudarmaji Sudarmaji , Hidayat Arif 
Published: March 2022

Abstrak : Tujuan dari penelitian ini adalah memberikan perancangan firewall filtering dan manajemen bandwidth menggunakan MikroTik Router, memperluas ruang lingkup jaringan di SMA Negeri 1 Seputih Banyak, Dalam penyusunannya penulis menggunakan metode R&D (Research and Development). Hasil dari penelitian ini berupa pengembangan sistem jaringan pada SMA Negeri 1 Seputih Banyak. Diantaranya, memperluas ruang lingkup untuk akses jaringan internet di lingkungan SMA Negeri 1 Seputih Banyak serta dibuatkan nya konfigurasi manajemen bandwidth dan firewall filtering untuk para siswa/siswi SMA Negeri 1 Seputih Banyak