bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rendre la culture accessible dans tous les territoires grâce au numérique
Authors: Fusillier Didier 
Published: March 2022

Le programme Micro-Folie, véritable plateforme au service des territoires, est un dispositif de politique culturelle porté par le ministère de la Culture et est coordonné par La Villette en lien avec douze partenaires fondateurs : le Centre Pompidou, le château de Versailles, la Cité de la musique-Philharmonie de Paris, le Festival d’Avignon, l’Institut du monde arabe, le Louvre, le musée national Picasso-Paris, le musée d’Orsay, le musée du quai Branly-Jacques Chirac, l’Opéra national de Paris, la Réunion des musées nationaux-Grand Palais et Universcience. Chaque Micro-Folie propose des contenus culturels ludiques et technologiques. Elle peut s’installer partout (dans une médiathèque, une salle des fêtes, un lieu patrimonial, le hall d’une mairie, un commerce, une école…) et ses activités, gratuites, s’adressent à tous les publics. Réseau culturel de proximité, Micro-Folie permet d’animer les territoires en s’adaptant à leurs besoins, dans un espace chaleureux et offrant une multitude d’activités accessibles.
« Classe des familles » : de la formation à la pratique
Authors: Mayer Charlotte , Bailly Rémi , Simbron Christine , Payen de la Garanderie Jérôme , Baleyte Jean-Marc 
Published: March 2022

L’implication des parents dans le milieu scolaire est un moyen important de soutenir la réussite des élèves. Les collaborations entre parents et enseignants sont de plus en plus reconnues comme vitales dans ce processus, et ce plus particulièrement lorsque les enfants présentent des difficultés scolaires. Les approches multifamiliales et multisystémiques ont démontré leur intérêt dans la prise en charge des troubles des conduites de l’enfant. Dans cet article, nous partagerons notre expérience de mise en place d’un dispositif de « classe des familles » (CDF) dans une école du Val-de-Marne (Ile-de-France, Paris). Nous tenterons d’en dégager les intérêts et les limites pour envisager de nouvelles perspectives et innovations en pédopsychiatrie.
Measuring the Impact of an Educational Intervention on Evidence-Based Practice
Authors: Waltz Lee Ann , Munoz Laura , Miller Rebecca A. , Weber Johnson Holly 
Published: March 2022

Background
With an increasingly complex health care system, there are greater demands for nurses to have a strong foundation in evidence-based practice (EBP) competencies because of their relationship to improved patient and organizational outcomes. Attributes such as knowledge, skills, and attitudes contribute to the development of EBP competencies.

Method
A quasi-experimental study with a pretest/posttest design was conducted to evaluate the outcomes for 30 RNs in an acute care setting who attended a 3-hour EBP educational intervention using the Healthcare EBP Assessment Tool questionnaire.

Results

The nurses demonstrated a significant improvement in their perceived understanding of EBP after the intervention (
p
= .005). Statistically significant improvements were also noted on the subscales of frequency, ability, desire, and barriers.

Conclusion

Advances in the perception of EBP competencies made by the participants of this intervention may enhance their feeling of contributing to the organization and result in improved patient outcomes and work environment. Further research is needed to investigate the effectiveness of other interventions, including opportunities to be involved in quality improvement projects and research studies.

[
J Contin Educ Nurs
. 2022;53(3):109–114.]
Du manuel de dessin à l'académie. La formation des artistes amatrices de la noblesse à Bruxelles au 19e siècle
Authors: Wiertz Wendy 
Published: March 2022

Au 19e siècle, les jeunes filles de la bourgeoisie, de la noblesse et des maisons royales d’Europe recevaient une éducation artistique. Si quelques-unes firent des arts leur métier en tirant profit d’une offre de formation en plein essor, la majorité – peu étudiée – d’entre elles pratiquait les arts en amateur. Cet article se concentre sur l’éducation artistique des artistes amatrices, en particulier celle des femmes de la noblesse dans le Bruxelles du 19e siècle. Pourtant très sensible à l’importance d’une éducation artistique, la noblesse ne vit naître dans ses rangs que de rares artistes professionnelles. La capitale offrait un vaste choix de formations. Des sources d’archives privées permettent d’approfondir les connaissances sur ces artistes amatrices et le paysage artistique de l’époque, tout en contextualisant les données liées aux artistes professionnelles.
L’utilisation de pesticides fait-elle partie des stratégies d’adaptation au changement climatique ? Analyse exploratoire dans le Fossé rhénan (France-Allemagne)
Authors: Bohnert Gaël , Martin Brice 
Published: March 2022

Alors que les conséquences des changements climatiques sont de plus en plus visibles et ne peuvent plus être totalement évitées, l’usage des pesticides en agriculture fait l’objet d’une profonde remise en cause, du fait de ses conséquences environnementales, économiques et sanitaires. L’agriculture est donc soumise à un double défi : s’adapter au changement climatique, et évoluer vers un modèle moins dépendant des pesticides. Ces enjeux sont particulièrement prégnants dans le Fossé rhénan, un espace transfrontalier partagé entre la France et l'Allemagne. En effet, cet espace où les conséquences des changements climatiques pourraient être exacerbées voit se côtoyer modèles traditionnels à forte utilisation de pesticides (grandes cultures intensives et viticulture réputée) et productions issues de l’agriculture biologique et de la biodynamie, surtout en viticulture. Le contexte local pourrait donc constituer une injonction à l’écologisation des pratiques agricoles. Or la réduction des traitements phytosanitaires et l’adaptation aux changements climatiques sont des objectifs parfois contradictoires, même si de nombreuses stratégies permettent de concilier les deux. Pour éclairer ce paradoxe, et comprendre le rôle des frontières multiples dans cet espace, on s’est appuyé sur la comparaison entre les filières (grandes cultures et viticulture) d’une part, et entre les pays (France et Allemagne) d’autre part. Ceci nous a permis de mettre en évidence les accélérateurs et les freins techniques, réglementaires, voire culturels à la mise en œuvre de stratégies gagnant-gagnant d’une transition agricole hétérogène et plutôt complexe.Les agriculteurs cherchent en effet à concilier différents objectifs, l’adaptation au changement climatique et/ou son atténuation, la réduction de l’usage des pesticides et la préservation de la biodiversité. Certes, cela est parfois utilisé comme un argument commercial, mais relève aussi souvent d’une réelle conviction personnelle pour laquelle les interactions sociales jouent un rôle important : informations diffusées par les organismes agricoles, échanges entre agriculteurs, réflexions et expérimentations personnelles, et expériences à l’étranger. Le contexte transfrontalier du Fossé rhénan prend toute son importance et, malgré les frontières multiples, favorise la prise de décision face aux enjeux environnementaux.
Au-delà de l'État. La vie sociale des pesticides dans le secteur maraîcher au Bénin
Authors: Houngnihin Roch Appolinaire , Gbégan Pascal Mègnissè , Doudou Dimi Theodore 
Published: March 2022

Dans les pays du Sud, l’agriculture urbaine est souvent critiquée en raison de ses pratiques polluantes dues, en grande partie, aux usages contraires aux normes officielles des pesticides sur les sites maraichers. Les rapports entre les acteurs intervenant dans la conception et la mise en œuvre des politiques publiques constituent l’un des registres de causalités de ces pratiques. Le présent article a pour objectif de répertorier et de décrire les acteurs structurant les usages des pesticides dans l’agriculture urbaine au Bénin, ainsi que leurs interactions. Le dispositif méthodologique est de type ethnographique ; il repose sur la recension de textes relatifs aux pesticides, des entretiens semi-directifs individuels et des observations directes sur des sites maraichers des trois principales villes du Bénin : Cotonou, Porto-Novo et Parakou. Au total, 55 acteurs relevant de différents profils ont été enquêtés. Plusieurs catégories d’acteurs interviennent sur les sites maraichers. Face aux logiques en présence (aussi bien divergentes que contradictoires), la « vie sociale » du pesticide échappe au contrôle des institutions étatiques. Les connaissances des producteurs et des vendeurs s’imposent et prévalent sur les recommandations officielles dans les transactions marchandes. Dans ce contexte, le vide institutionnel créé par les agents du secteur public est comblé par des acteurs spéciaux, les « distributeurs-encadreurs ». Par ailleurs, les conflits intergénérationnels entre producteurs, suscités sur fond d’intrigues politiques, sont récurrents dans l’accès aux ressources matérielles et financières disponibles. De telles situations fragilisent le secteur maraicher et interfèrent négativement dans la mise en œuvre des politiques publiques relatives aux pesticides.
Transition écologique : du défi scientifique au défi pédagogique
Authors: Delplancke Malou , Picard Sylvain , Patillon Camille , Kervarrec Maude , Vimal Ruppert 
Published: March 2022

La crise écologique à laquelle nous sommes confrontés invite à renouveler notre façon de faire science. À l’aune du développement durable, l’enjeu est de produire une science démocratique et capable de répondre aux enjeux contemporains. Ce contexte interpelle le rôle de l’école dans ses logiques de construction et de transmission des savoirs scientifiques. L’émergence des questions socialement vives (QSV) dans l’enseignement est une opportunité pour contribuer à une éducation qui permette de penser et d’agir dans un monde complexe et incertain. Cet article est fondé sur l’étude d’un dispositif éducatif expérimental centré sur une démarche d’enquête en lien avec la transition écologique de l’île d’Yeu, dans le département français de la Vendée. Il se propose d’analyser, du point de vue des pédagogues et des apprenants, quelles sont les implications d’un enseignement scientifique qui cultive l’interdisciplinarité, l’implication et la participation. Au-delà des difficultés matérielles et épistémiques identifiées, ainsi que des tensions qu’il y a à coconstruire connaissances et actions, notre expérimentation révèle plusieurs leviers d’action possibles pour l’éducation au développement durable (EDD) parmi lesquels l’ouverture du collectif à une pluralité d’acteurs, l’importance de ménager des espaces de réflexivité et la nécessité de développer une ingénierie sociale.éducation au développement durable (EDD), question socialement vive (QSV), interdisciplinarité, transition écologique, participation, co-construction des savoirs
Protein Tyrosine Phosphatase PTPRO Signaling Couples Metabolic States to Control the Development of Granulocyte Progenitor Cells
Authors: Li Yan , Jia Anna , Yang Hui , Wang Yuexin , Wang Yufei , Yang Qiuli , Cao Yejin , Bi Yujing , Liu Guangwei 
Published: March 2022

Abstract
Protein tyrosine phosphatase (PTPase) is critically involved in the regulation of hematopoietic stem cell development and differentiation. Roles of novel isolated receptor PTPase PTPRO from bone marrow hematopoietic stem cells in granulopoiesis have not been investigated. PTPRO expression is correlated with granulocytic differentiation, and Ptpro−/− mice developed neutrophilia, with an expanded granulocytic compartment resulting from a cell-autonomous increase in the number of granulocyte progenitors under steady-state and potentiated innate immune responses against Listeria monocytogenes infection. Mechanistically, mTOR and HIF1α signaling engaged glucose metabolism and initiated a transcriptional program involving the lineage decision factor C/EBPα, which is critically required for the PTPRO deficiency-directed granulopoiesis. Genetic ablation of mTOR or HIF1α or perturbation of glucose metabolism suppresses progenitor expansion, neutrophilia, and higher glycolytic activities by Ptpro−/−. In addition, Ptpro−/− upregulated HIF1α regulates the lineage decision factor C/EBPα promoter activities. Thus, our findings identify a previously unrecognized interplay between receptor PTPase PTPRO signaling and mTOR-HIF1α metabolic reprogramming in progenitor cells of granulocytes that underlies granulopoiesis.
Long-term follow-up results of testicular torsion in children
Authors: Yu Cheng-Jun , Zhao Jie , Luo Jin , Hong Yi-Fan , Zhao Tian-Xin , Wen Sheng , Jiang Li , Lin Tao , He Da-Wei , Wei Guang-Hui , Wu Sheng-De 
Published: March 2022

ABSTRACT
A retrospective cohort study was conducted at the Children’s Hospital of Chongqing Medical University from November 2004 to December 2020 to investigate the long-term follow-up results after testicular torsion (TT) in children. Boys with TT were divided into the salvage orchiopexy group and the orchiectomy group, and the baseline characteristics, ultrasonographic indications, intraoperative findings, testicular volumes, and adverse events during follow-up were compared. A total of 145 cases were included in this study. Approximately 56.6% of patients who underwent salvage orchiopexy had testicular atrophy (TA), and the median testicular volume loss of the testes was 57.4%. Age less than 6 years, delayed surgery, and intraoperative poor blood supply were associated with TA in pediatric TT after orchiopexy. Most atrophied testes appeared within 3–6 months after surgery. Compared with the corresponding age-matched healthy controls, the contralateral testicular volumes were larger in the orchiopexy (P = 0.001 without TA, and P = 0.042 with TA) and orchiectomy groups (P = 0.033). The adverse events were comparable in patients with orchiectomy or orchiopexy. In summary, follow-up before 3 months after surgery may not offer sufficient clinical value, while that 3 months after surgery should be regarded as the first follow-up time for testicular monitoring. The contralateral testes of patients with TT showed compensatory hypertrophy. We suggest performing orchiectomy when torsed testes are surgically assessed as Arda grade III or inviable.
Medical and psychological comorbidity among COVID patients during the first wave in Dharwad District of South India
Authors: Shetty Kannappa V. , Desai Mahesh , Srivastava Ashish , Marimuthu P. , Manikappa Sanjeev Kumar , Bamney Urmila 
Published: March 2022

Background:
The COVID-19 is a viral communicable disease and the World Health Organization declared it as a public health emergency of international concern. This pandemic has challenged the entire world including India's health-care system and resources. It is a devastating recurrence in people with underlying health issues or comorbidities, eventually resulting in mortality. Comorbidities including both medical and psychological disorders among COVID patients have a large amount of impact on the individual's mental health as well as functioning.

Materials and Methods:
The study comprised 800 hospitalized COVID-19 patients during the first wave from North Karnataka region in India. The data were collected using a structured interview schedule through hospital telephones. The ethical approval was obtained from the Institute Research Ethics Committee.

Results:
The mean age of the hospitalized COVID patients was 41.02 ± 15.21, and the mean age of comorbidity was 47.69 ± 14.84. Following medical comorbidities such as diabetes (9.3%), hypertension (9.3%), cancer (1.8%), diabetes + hypertension (2.1%), and asthma (0.9%) and psychological comorbidities such as anxiety (3.8%) and depression (3.3%) were found among the hospitalized COVID patients during the first wave.

Conclusions:
It can be observed that comorbidity may increase the risk of death among COVID patients who were hospitalized and appropriate medical and psychological interventions can be provided for various co comorbidities at the earliest to prevent further defuncting and distress caused by the pandemic.
Correlation of neurological soft signs with neuropsychological performance in persons with schizophrenia
Authors: Sachin B. S. , Pathak Kangkan , Avinash Priyaranjan , Saxena Vrinda , Victor Robin 
Published: March 2022

Background:
Neurological soft signs (NSS) are subtle motor and sensory deficits that are frequently found in various psychiatric disorders including schizophrenia. NSS in schizophrenia are frequently associated with impairment in cognitive abilities and deterioration in neuropsychological performance (NP).

Objective:
We aimed to study the correlation between NSS and NP in persons with schizophrenia.

Methods:
Sixty individuals of whom thirty had schizophrenia according to the International Classification of Diseases 10th Revision and the rest thirty were matched controls were selected based on inclusion and exclusion criteria. Demographic and clinical details were obtained and tests for the assessment of NSS and neuropsychological assessment were administered. Comparison based on scores obtained in these scales was made in both the groups.

Results:
NSS were present in 100% of patients with schizophrenia and in 16.6% of controls in the control group. There was a statistically significant difference between the two groups in neuropsychological assessment. In Group 1, NSS showed a significant negative correlation with Tower of London, Stroop Color-Word Test, Digit Vigilance Test, and Digit Symbol Substitution Test. However, there was no correlation between NP and NSS in Group 2.

Conclusion:
NSS were more in persons with schizophrenia compared to healthy normal controls. Furthermore, there is a negative correlation between NSS and NP in persons with schizophrenia, which is differing from the control group. We may conclude that the presence of NSS predicts the poor NP, and also contributes to poor cognitive abilities of persons with schizophrenia.
Ameliorative effect of costus ethanolic extract against Oxaliplatin-induced hepatotoxicity in adult rats
Authors: Elshater Abd Elraheem A. , Ashry Mahmoud , Ahmed Hend , Abdel-Wahhab Khaled G. , Morsy Fatma Adly , Abd-Elstar Rana 
Published: March 2022

Background and objective
Cancer is a disease associated with an abnormal proliferation and growth of living cells; treatment with the anticancer therapy, Oxaliplatin (OXP) results in hepatotoxicity. The objective of this study was to evaluate the protective effect of costus ethanolic extract (CEE) against OXP-induced hepatotoxicity in a trail to improve its clinical use.

Materials and methods
Adult male Wistar rats (150–180 g body weight) were randomly divided into four groups (10 rats each): (a) healthy control group, (b) healthy rats treated orally with CEE (50 mg/kg/day), (c) rats injected intraperitoneally with OXP (10 mg/kg once/week), and (d) rats treated with CEE in combination with OXP.

Results and conclusion
After 6 weeks of treatment, the results revealed that CEE succeeded to decline OXP-induced hepatotoxicity; this was evidenced by the significant reduction in serum alanine aminotransferase (ALAT), aspartate aminotransferases (ASAT), GGT, alkaline phosphatase (ALP), total cholesterol, triglycerides, low dense lipoprotein-cholesterol (LDL-c), tumor necrosis factor-alpha (TNF-α), Interleukin -1 Beta (IL-1β), and alpha-fetoprotein values as well as hepatic malondialdehyde, nitric oxide, and DNA fragmentation coupled with a marked rise in serum CD4, albumin and high dense lipoprotein-cholesterol (HDL-c) levels, and hepatic glutathione, superoxide dismutase, and catalase values. These effects agonized the structural restoration of the histological picture of liver. It could be concluded that CEE succeeded to a great extent to counteract the oxidative stress of OXP and protect the liver against its toxic effects; CEE may be considered as a promising supplement-candidate for the protection of liver against the side effects of that anticancer drugs.
Effect of inositol on ciprofloxacin-induced depression in rats through upregulation of Keap1-Nrf2 system
Authors: Salama Abeer , Elhadidy Mohamed E. , El-Kassaby Mahitab , Farrag Abdel Razik H. 
Published: March 2022

Background
Kelch-like erythroid cell-derived protein 1 (Keap1)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2) are transcription factors that can protect against oxidative stress and inflammation. Its deficiency has a contributory role in depression. Inositol is a nutritional supplement that is linked to various neurotransmitter receptors, such as serotonin. In the current study, we aimed to investigate the influence of inositol on ciprofloxacin (CPX)-induced depression through the upregulation of Keap1/Nrf2 system.

Materials and methods
Animals were divided into four groups as follows: group I: the normal control group that received saline. Group II (depressed group): rats treated daily with CPX (50 mg/kg body weight) for 14 days. Groups III and IV: rats received daily inositol (0.625 and 1.25 mg/kg body weight) for 14 days concurrently with daily dose of CPX. Forced swimming, oxidative biomarkers such as nitric oxide, malondialdehyde, and glutathione-s-transferase, and Keap1-Nrf2 and serotonin brain contents were assessed.

Results and conclusion
CPX-induced oxidative stress, reduced swimming time, and serotonin (5-HT) brain contents and showed severe neural injury in the form of spongiosis, focal gliosis around the degenerating neurons, and injured neurons revealed differences in sizes, vacuolization, shrinking, apoptosis, and lysis. An elevation of swimming time, brain glutathione-s-transferase, serotonin contents with a decrease of nitric oxide and malondialdehyde, and ameliorated histopathological alterations were observed in the inositol-administered group with respect to the CPX group. In conclusion, inositol alleviated neurological toxicity and has antidepressant activity through the downregulation of oxidative stress pathway and upregulation of 5-HT level and Keap1/Nrf2 system.
Mushrooms as efficient biocontrol agents against the root-knot nematode, meloidogyne incognita
Authors: Soliman Gaziea , Elkhateeb Waill , Wen Ting-Chi , Daba Ghoson 
Published: March 2022

Background
Root-knot nematodes in general and Meloidogyne incognita, in particular, are pests that cause agricultural losses. Currently, nematode control relies on chemical nematicides, which are hazardous to the environment and human health. The increasing demand for ecofriendly nematicides has prompted researchers to look into biocontrol agents that act as efficient and long-lasting alternatives to the currently used chemicals.

Objective
The aim of the study was to evaluate the in-vitro nematicidal activity of eight mushroom (Cordyceps militaris, Metacordyceps neogunnii, Hericium erinaceus, Dictyophora indusiata, Cerioporus squamosus, Tirmania nivea, Tirmania pinoyi, and Agaricus impudicus) extracts against M. incognita juveniles and eggs.

Materials and methods
Hydromethanolic extracts were prepared from the fruiting bodies of mushrooms under investigation. Then the obtained extracts were evaluated for their in-vitro nematicidal activity against M. incognita juveniles’ second stage after 24, 48, and 72 h of treatment, also against their eggs.

Results and conclusion
All tested mushroom extracts were capable of inducing mortality in M. incognita second stage juveniles with mortality percentages ranging from 79.3 to 97%. On the other hand, the tested mushroom extracts exhibited some nematostatic and nematicidal activity against M. incognita eggs as compared with the control after 7 days using 80 µl/ml concentration. The tested mushroom extracts caused suppression in M. incognita eggs hatching with inhibition rates that ranged from 59.38 to 81.25%. A. impudicus hydromethanolic extract showed the highest inhibition as compared with the control and other tested mushroom extracts as it caused a relative suppression that reached 81.25% against M. incognita eggs after 7 days of exposure. The same mushroom extract has achieved a juveniles mortality of 97%. A. impudicus extract is nominated as a potential nematicidal agent. Further studies are required to confirm the potency of this extract and analyze its chemical profile.