bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of mHealth and education-led peer counselling of patients with hypertension and coronary artery disease in Pakistan: Study protocol for a double-blinded pragmatic randomized-controlled trial with factorial design
Authors: Arshed Muhammad , Zakar Rubeena , Umer Muhammad Farooq , Ullah Najeeb , Iftikhar Ghazala , Kiran Mehwish , Fischer Florian 
Published: September 2022

Abstract
Background: Hypertension is a highly relevant public health challenge. Digital interventions may support in improving adherence to anti-hypertensive medications and alter health behavior. Therefore, this protocol describes a study which aims to assess the effectiveness of mHealth and educational support through peer counseling (Ed-counselling) to control blood pressure in hypertensive patients when compared to standard care.
Methods: We chose a double-blinded pragmatic randomized-controlled with factorial design for this investigation. The trial is going to recruit 1440 hypertensive patients with coronary artery disease at the age of 21 to 70 years. All participants will already be on anti-hypertensive medication and own a smartphone. They will be randomized into four groups with each having 360 participants. The first group will only receive standard care; while the second group, in addition to standard care will receive monthly Ed-counselling (educational booklets with animated infographics and peer counselling); the third group will receive daily written and voice reminders and an education-led video once weekly together with standard care; while the fourth one gets both interventions given to second and third groups respectively. All groups will be followed-up for one year (0, 6, and 12 months). The primary outcome will be the change in systolic blood pressure while secondary outcomes include health-related quality of life and changes in medication adherence.
Discussion: Besides adding up to existing evidence in the literature on the subject, our designed modules using mHealth technology can help reducing hypertension-related morbidity and mortality in developing countries.
Trial registration: ClinicalTrials.gov (NCT05106790), October 24, 2021
Expression of an Insecticidal Protein under Phloem Specific Promoter in Cotton Plants to Control Whitefly
Authors: Hussain Sonia , Aslam Muhammad , Ahmed Nasim , Jamil Mahnoor , Rauf Imran , Aftab Shaheen , Amin Imran , Mansoor Shahid 
Published: September 2022

Abstract
Whitefly the Bemisia tabaci is a phloem sap-sucking hemipteran pest that causes enormous damage to many crop plants, particularly cotton. Bt endotoxins which successfully controlled the chewing pest proved to be mostly ineffective against the whiteflies and many other hemipteran pests. In the past few years, some insecticidal proteins showed significant toxicity against the whiteflies such as Hvt, lectin, and TMA12. In this study, transgenic cotton lines expressing plant-derived insecticidal protein TMA12 under constitutive promoter (2X35S derived from Cauliflower mosaic virus-CaMV) and a phloem-specific promoter (Nuclear shuttle protein-NSP derived from Banana bunchy top virus-BBTV) were developed to compare their efficacy against the whiteflies. Before developing cotton transgenic lines, tobacco transgenic plants were also developed to get preliminary results about the efficacy of the transgene. After molecular characterization, cotton transgenic lines were evaluated for resistance against whitefly in the contained environment. Whitefly survival and fecundity were calculated for each transgenic line. Bioassay data proved the effectiveness of insecticidal protein against whiteflies. These results also concluded that the NSP promoter is potentially an effective strategy against B. tabaci but still its efficiency is not equal to the 2X35S promoter. The use of a phloem-specific promoter has advantages over the constitutive promoter like tissue-specific expression saves the molecular resources of the plant cells and is less prone to biosafety concerns. In the future, more phloem-specific promoters can be explored for enhanced effectivity against B. tabaci.
Extended DNA threading through a dual-engine motor module in the activating signal co-integrator complex
Authors: Jia Junqiao , Hilal Tarek , Bohnsack Katherine , Chernev Aleksandar , Tsao Ning , Schwarz Juliane , Arumugam Aruna , Parmely Lane , Holton Nicole , Loll Bernhard , Mosammaparast Nima , Bohnsack Markus , Urlaub Henning , Wahl Markus 
Published: September 2022

Abstract
Activating signal co-integrator complex (ASCC) supports diverse genome maintenance and gene expression processes. Its ASCC3 subunit is an unconventional nucleic acid helicase, harboring tandem Ski2-like NTPase/helicase cassettes crucial for ASCC functions. Presently, the molecular mechanisms underlying ASCC3 helicase activity and regulation remain unresolved. Here, we present cryogenic electron microscopy, DNA-protein cross-linking/mass spectrometry as well as in vitro and cellular functional analyses of the ASCC3-ASC1/TRIP4 sub-module of ASCC. Unlike the related spliceosomal SNRNP200 RNA helicase, ASCC3 can thread substrates through both helicase cassettes. ASC1 docks on ASCC3 via a zinc finger domain and stimulates the helicase by positioning a C-terminal ASC1-homology domain next to the C-terminal helicase cassette of ASCC3, likely assisting the DNA exit. ASC1 binds ASCC3 mutually exclusively with the DNA/RNA dealkylase, ALKBH3, directing ASCC for specific processes. Our findings define ASCC3-ASC1/TRIP4 as a tunable motor module of ASCC that encompasses two cooperating ATPase/helicase units functionally expanded by ASC1/TRIP4.
The perceptions of university students on technological and ethical risks of using robots in long-term care homes
Authors: Young Erika , Hung Lillian , Wong Joey , Wong Karen , Yee Amanda , Mann Jim , Vasarhely Krisztina 
Published: September 2022

Abstract
Background
The COVID-19 pandemic has disproportionately impacted LTC residents and exacerbated residents’ risks of social isolation and loneliness. The unmet emotional needs of residents in LTC have driven researchers and decision-makers to consider novel technologies to improve care and quality of life for residents. Ageist stereotypes have contributed to the underuse of technologies with the older population. Telepresence robots have been found easy-to-use and do not require older adults to learn how to operate the robot but is remotely controlled by family members. There is a need for exploring perceptions around the implementation of these technologies with older adults living in long-term care.
Methods
Between December 2021 and March 2022, our team conducted interviews with 15 multidisciplinary students. We employed a qualitative descriptive (QD) approach with semi-structured interview methods. Our study aimed to understand the perspectives of university students (under the age of 40) on using telepresence robots in LTC homes. Participants were given a link to a 2-minute video of how the robot works prior to the interview. Also, they were invited to spend 15 minutes remotely driving a telepresence robot prior to the interview. A diverse team of young researchers and older adults (patient and family partners) conducted reflexive thematic analysis together.
Results
Six themes were identified: (1)Robots as supplementary interaction, .(2) privacy, confidentiality, and physical harm, (3) increased mental well-being and opportunities for interactions. (4) intergenerational perspectives add values , (5) staffing capacity (6) environmental and cultural factors influence acceptance
Conclusion
We identified a generational difference in opinions and thoughts regarding risk and privacy of using telepresence robots in long-term care. Participants shared the importance of the voice of the resident and their own for creating more equitable decision-making and advocating for including this type of technology within long-term care. Our study would contribute to the future planning, implementation, and design of robotics in LTC.
Auto-identification of dominant modal parameters from multi-batch signals based on weighted-SSA to suppress milling vibration
Authors: Peng Yili , Chen Xubing , Jiang Xuchu , Huang Kuntao , Fu Zhongtao 
Published: September 2022

Abstract
Facing the characteristics of big data in modern industrial system, manually retrieving the data from many different batches of vibration signals for modal analysis will cause low data utilization and low efficiency. At the same time, under cutting condition, the harmonic component generated by the rotating excitation of machine tool interferes the auto-identification of structural modal parameters from a large number of vibration signals. Therefore, to realize the auto-identification of structural dominant modal parameters from large amounts of different batches vibration data under cutting condition, a new weighted-SSA (singular spectrum analysis) method is proposed in this paper. First, multi batch on-site vibration signals are decomposed, and the eigenvalue and matrix are extracted through singular value decomposition. Then, based on the variance filtering of principal component analysis, a half principal component analysis is proposed to extract the weighted vector of the eigen matrix. and clustering is adopted to average the noise reduction signals, to realize the automatic screening of a large amount of data and the automatic distinction of modal parameters. Third, the identified dominant mode of the structure with weak link is optimized through the genetic algorithm, to achieve the suppression of spindle tool system vibration. Finally, the cutting tests are conducted to verify the feasibility and effectiveness of the auto-identification and optimization method.
Prevalence of Perinatal Factors in Infants with Brachial Plexus Birth Injuries and their Association with Injury Severity
Authors: Manske Mary Claire , Miller Patricia , Bauer Andrea 
Published: September 2022

Abstract
Objectives
To determine the prevalence of perinatal factors associated with brachial plexus birth injury(BPBI) in affected infants and their relationship with BPBI severity.
Study Design
Retrospective study of BPBI infants prospectively enrolled in a multicenter registry. The prevalence of perinatal factors were calculated. Infants were stratified by injury severity and groups were compared to determine the association of severity and perinatal factors.
Results
Seven-hundred-ninety-six BPBI infants had a mean 4.2 ± 1.6 perinatal factors. Nearly all (795/796) reported at least one factor, including shoulder dystocia(96%), no clavicle fracture (91%), difficult delivery(84%), parity > 1(61%) and birthweight > 4000g(55%). Ten-percent (74/778) had Horner’s syndrome and 28%(222/796) underwent nerve surgery. Birth asphyxia and NICU admission were significantly associated with injury severity.
Conclusions
NICU admission and asphyxia were associated with BPBI severity. Improved understanding of the relationship between perinatal factors and BPBI severity may be used to guide early referral to BPBI providers and support prevention efforts.
Comparision of Hydrological Forecast Methodologies Applied to a Small Mountain Watershed
Authors: Fagundes Marina , Fan Fernando Mainardi , Gama Cléber Henrique de Araújo , Campagnolo Karla , Paixão Maurício Andrades , Kobyiama Masato 
Published: September 2022

Abstract
A comparison of methodologies was carried out to develop an operational flow forecasting system for a mountainous basin. The case studied was the Boi river, which is located in a small mountainous watershed in southern Brazil. This watershed is part of a conservation unit well known for the ecotourism activities carried out in that place. Among the activities, the Boi river trail can be highlighted, which is carried out following the riverbed. For this reason, the development of an alert system for this basin can help in determining the trail's closure in situations where the water flow is strong and could present risks to tourists safety. Thereby, two different scenarios were considered for the development of the forecasting system. First, the flow forecasts were performed using SOPREVA and considered a horizon of 1 day (short term forecasts). The second scenario considered medium-term forecasts (1 to 10 days horizon) and utilized the HEC-RTS as a basis for developing the forecast system. In both cases, the forecasts were based on the ensemble precipitation estimates of GEFS. The obtained results showed that the actual alarm rates were 0.77 and 0.86 for SOPREVA and HEC-RTS, respectively, when considering a horizon of one day in advance. The evaluation of the medium-term forecasts presented good results of this system for horizons up to 3 days in advance. Finally, the results of both considered scenarios showed that the systems could be used as a basis for management of the Boi river trail.
Postoperative arrhythmia after lower gastrointestinal surgery- the blind spot of postoperative care?
Authors: Rühlmann Felix , Hedicke Mara Sophie , Engelhardt Deborah , Mackert Alma Franziska , Tichelbäcker Tobias , Leha Andreas , Bernhardt Markus , Ghadimi Michael , Perl Thorsten , Azizian Azadeh , Gaedcke Jochen 
Published: September 2022

Abstract
Introduction: Postoperative arrhythmias (PAs) are common events and have been widely investigated in cardiothoracic surgery. Within visceral surgery, a recent study revealed a significant occurrence of PA in esophageal resections. In contrast, PA in lower gastrointestinal surgery is rarely investigated and has been rudimentary described in the medical literature.
Methods: In total, 1171 patients (559 female, 612 male) without any history of prior arrhythmia who underwent lower GI surgery between 2012 and 2018 were included and retrospectively analyzed. All included patients were treated and monitored in the intensive care unit (ICU) or intermediate care unit (IMC) after surgery. Follow-up was obtained for the patients with PA investigating the possible persistence of PA and complications such as permanent arrhythmia or thromboembolic events after discharge.
Results: Overall, PA occurred in n=56 (4.8%) patients after surgery of the lower GI. The highest incidence of PA was seen in patients undergoing bowel surgery after mesenteric ischaemia (26.92%), followed by cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC; 16.67%). PA was significantly associated with higher age (p<0.001) and longer length of stay in the ICU (p<0.001). PA was independently associated with organ failure (p<0.001) and higher in-house mortality (p<0.001). In median, PA occurred 66.5 hours after surgery. In follow-up, 31% of the patients showed development of permanent arrhythmia.
Discussion: The incidence of PA after lower GI surgery is comparatively low. Its occurrence, however, seems to have severe implications since it is significantly associated with higher rates of organ failure and in-house mortality. Also, compared to the general population, the development of permanent arrhythmia is significantly higher in patients who developed new-onset PA.
Quantitative flow ratio vs. angiography- only guided PCI in STEMI patients: a one- year outcomes
Authors: Barauskas Mindaugas , Žiubrytė Greta , Jodka Nojus , Unikas Ramūnas 
Published: September 2022

Abstract
Background

Coronary physiology-guided PCIs are recommended worldwide. However, invasive coronary physiology methods prolong the procedure, make additional risks for the patients, and prolong the fluoroscopy time for an interventional cardiologist. Otherwise, there is a non-invasive coronary physiology evaluation method QFR, which can be safely used even in STEMI patients.

Methods

198 patients admitted with STEMI and at least one intermediate (35–75%) diameter stenosis other than culprit artery between July 2020 and June 2021 have been prospectively included in this single-centre study. All patients were randomized into one of two groups (1 - QFR-guided PCI; 2 - visual-estimation-only guided PCI). A 12-month follow-up with echocardiography, exercise stress test, and quality of life evaluation was performed in all included patients. For the QOF evaluation, the Seattle angina score questionnaire was chosen. Statistical analysis was performed using Kolmogorov-Smirnov, Stjudent T, Mann-Whitney, Pearson Chi-square tests and Kaplan Meier survival analysis.

Results

98 (49.5%) patients were randomized to the first group, and 100 (50.5%) patients were included in the second group. Statistically, significantly more patients had a medical history of dyslipidaemia (98 vs 91, p = 0.002) and slightly better left ventricular ejection fraction (42.21 ± 7.88 vs 39.45 ± 9.62, p = 0.045) in the QFR group. Six times fewer patients required non-culprit artery revascularization within 12-month FU in the QFR group (1.02% vs 6%, p = 0.047). Survival analysis proved that patients in the Angio group had more than 6-time greater risk for death within a 12-month period after MI (OR 6.23, 95% CI 2.20-17.87, p = 0.006), with the highest mortality risk within the first two months after initial treatment.

Conclusions

Using QFR in non-culprit lesions for patients with ST-elevation myocardial infarction reduces mortality rate and revascularization in 12-month follow-up and increases the patient's quality of life.

Trial registration

The study was approved by the Regional Bioethical Committee and conducted under the principles of the Helsinki Declaration and local laws and regulations.
Experimental investigation and numerical Analysis using Taguchi and ANOVA Method for Underwater Friction Stir Welding of aluminium alloy 2017 process improvement
Authors: madani tahar , BOUKRAA mousatfa , aissani mouloud , chekifi tawfiq , ziadi abdelkadar , zirari mounir 
Published: September 2022

Abstract
The effect of under water friction stir welding for 5 mm AA2017 aluminum alloy plaque on mechanical properties has been examined, nine different test were designed according to Taguchi orthogonal array (OA) without changing the welding tool. Three variable operating parameters (Welding velocity, rotational velocity and axial force) with three levels for each parameter have been used. The effects of each FSW parameters on the weld joint were discussed and analysed, the analysis of variance (ANOVA) is adopted to identify the contribution of each FSW underwater parameters. The statisticl Taguchi method (MT) was employed to pridect the optimal combination of welding parameters to improve the tensile properties such tensile strength (TS) of welded joints as retaining high production rates. The experimental tests show good agreement with the results estimated by the proposed mathematical model. Where the obtained validation results confirm the robustness of the optimization method as a tool for improving the quality responses of under water friction stir welding.
The Case for Minimax-TD
Authors: Darlington Richard B. 
Published: September 2022

Abstract
In spatial-model computer simulations with artificial voters and candidates, the well-known minimax single-winner voting system far outperformed 10 other systems at picking the best winners. It essentially tied with two others (Schulze and ranked pairs), both of which are far more complex than minimax. Minimax’s other advantages include Condorcet consistency, simplicity, monotonicity, and ease of voting because it allows tied and missing ranks. It also makes insincere strategic voting schemes difficult and dangerous for the schemers. The new minimax-TD system modifies minimax in three ways, all of which make it pick better winners, according to simulation studies: (a) TD includes Smith/minimax, (b) TD uses one particular definition of a candidate’s “largest loss” in two-way elections, and (c) TD includes a multi-stage tie-breaker which breaks nearly all ties. TD avoids four of the worst anomalies afflicting classic minimax. Four other minimax anomalies can be ignored, leaving TD arguably free of anomalies.
JEL Classification D71 D72
circKIF4A promotes proliferation and brain metastasis in triple-negative breast cancer through autophagy by sponging miR-637
Authors: Wu Song , Li Xing , Zhu Lewei , Wu Feiyue , Zhang Yue , Wu Linyu , Lu Jibu , Li Yuehua , Tang Hailin 
Published: September 2022

Abstract
Background
Among patients with triple-negative breast cancer (TNBC), distant metastasis is the leading cause of death. Our previous studies have shown that TNBC progression is greatly facilitated by circKIF4A, but uncertainty remains regarding the role of which in TNBC brain metastasis and its molecular mechanism.
Methods
In this study, RNA sequencing was used to identify circKIF4A from 22 pairs of primary breast cancer and brain metastases. Validation of circKIF4A expression and existence was performed using FISH and RT-qPCR assays. It was demonstrated that circKIF4A plays an oncogenic role both in vitro and in vivo. Western blot and dual-luciferase reporter assays were used to confirm the interaction of circKIF4A, miR-637, STAT3, p62 and beclin.
Results
In this study, we detected notable upregulation of circKIF4A in TNBC cell lines and brain metastasis. Inhibition of circKIF4A impairs TNBC’s ability to proliferate, migrate, and brain metastasis. Luciferase reporter assays confirmed that circKIF4A competed for binding to miR-637 with STAT3. Western blot analysis revealed that inhibition of circKIF4A decreased STAT3 and p62 expression, and increased the expression of Beclin, confirming that downregulation of circKIF4A induced autophagy by competing with STAT3 to bind to miR-637.
Conclusion
By employing competitive endogenous RNA (ceRNA) mechanism, the circKIF4A-miR-637-STAT3 axis coordinates TNBC brain metastasis. circKIF4A can therefore be used as a prognostic biomarker for TNBC brain metastasis and as a therapeutic target.
The impact of COVID-19 lockdown on maternal and neonatal outcomes of uninfected woman in late pregnancy: A multicenter study in China
Authors: Lin Ting-ting , Chen Yang , Wang Hong-lin , Li Chao , Zhang Ting , Fan Li-chun , Huang He-feng , Wu Yan-ting , Wen Yang 
Published: September 2022

Abstract
Background
COVID-19 pandemic has had direct and indirect impacts on health-care system and maternal and neonatal health, but no multicenter evidence from China of this effects has been undertaken. The purpose of this study was to investigate the impacts of COVID-19 lockdown on maternal and fetal outcomes in China.
Methods
This retrospective cohort study included 3540 women in their late pregnancy without COVID-19 who received perinatal healthcare in three hospitals in Wuhan, Shanghai and Haikou during COVID-19 lockdown period in 2020 or the non-lockdown period in 2019. Propensity-score matching was used to compare preterm birth (< 37 weeks) and its classification, very preterm birth (< 34 weeks), caesarean section and its indications, the length of hospital stay, birth weight and other pregnancy outcomes between two groups.
Results
Preterm births before 37 weeks’ gestation (5.4% vs. 5.3%, P = 0.83) and very preterm birth (0.7% vs. 0.8%, P = 0.58) were not significantly changed overall. But medical-induced preterm birth before 37 weeks’ gestation in Wuhan was decreased (0.8% vs. 1.7%, P = 0.04). The cesarean section for maternal factors was decreased (21.4% vs. 24.3%, P = 0.003). The length of maternal (4.2d vs 4.5d, P < 0.001) and neonatal (3.4d vs 3.7d, P < 0.001) hospital stay was shortened. No overall significant effects were identified for other outcomes included in the quantitative analysis: maternal gestational diabetes; pregnancy-induced hypertension; preterm birth with premature rupture of membranes; low birthweight (< 2500 g); neonatal intensive care unit admission; or abnormal Apgar score.
Conclusions
This study demonstrated that there was protective impact of the COVID-19 lockdown on maternal and neonatal outcomes among women in their late pregnancy in China.