bluuebunny/crossref_metadata_2025_split huggingface dataset:
The fruit glossiness locus, dull fruit (D), encodes a C2H2-type zinc finger transcription factor, CsDULL, in cucumber (Cucumis sativus L.)
Authors: Zhai Xuling , Wu Haoying , Wang Yaru , Zhang Zhongren , Shan Li , Zhao Xi , Wang Ruijia , Liu Chang , Weng Yiqun , Wang Ying , Liu Xingwang , Ren Huazhong 
Published: July 2022

Abstract
Fruit glossiness is an important external fruit quality trait for fresh-consumed cucumber fruit, affecting its marketability. Dull fruit appearance is mainly controlled by a single gene, D (for dull fruit) that is dominant to glossy fruit (dd), but the molecular mechanism controlling fruit glossiness is unknown. In the present study, we conducted map-based cloning of the D locus in cucumber and identified a candidate gene (Csa5G577350) that encodes a C2H2-type zinc finger transcription factor, CsDULL. A 4895-bp deletion including the complete loss of CsDULL resulted in glossy fruit. CsDULL is highly expressed in the peel of cucumber fruit, and its expression level is positively correlated with the accumulation of cutin and wax in the peel. Through transcriptome analysis, yeast one-hybrid and dual-luciferase assays, we identified two genes potentially targeted by CsDULL for regulation of cutin and wax biosynthesis/transportation that included CsGPAT4 and CsLTPG1. The possibility that CsDULL controls both fruit glossiness and wart development in cucumber is discussed. The present work advances our understanding of regulatory mechanisms of fruit epidermal traits, and provides a useful tool for molecular breeding to improve external fruit quality in cucumber.
Atomic aesthetics: gender, visualization and popular culture in Egypt
Authors: Taha Hebatalla 
Published: July 2022

Abstract
How was the atomic age visualized in Egypt in the years immediately after the creation of the bomb? What role did gendered images, symbols and metaphors play in narrating and normalizing nuclear technology? How can these help us understand nuclear policy today? This article engages visual and textual media, including satirical magazines, cultural journals and film. It presents a plurality of images: the depiction of the bomb as an egg, as a miniscule and aesthetically pleasing object, alongside more alarming illustrations of the bomb as a monster. Through fluid and unstable visualizations, nationalist modernizers highlighted the ambivalence of nuclear technology, seen as containing potential for postcolonial rebirth and global death simultaneously. By exploring nuclear imaginaries from the decolonizing world, the article challenges the dominant narratives, histories and aesthetics of the atomic age. Despite the continuous reiteration of nuclear weapons as masculine in feminist International Relations, this conceptualization is not necessarily universal, and this research illustrates that feminizing nuclear imagery can still reinforce the nuclearized world. Considering visualization from, and not only of, the global South, the article emphasizes that people in non-nuclear weapons-possessing states also participated in the production of the nuclear-armed world and in discussions on the nuclear condition.
Alterations in the Course of Inflammatory Bowel Disease Following Liver Transplantation: A Systematic Review and Meta-analysis
Authors: Safarpour Ali Reza , Shojaei-Zarghani Sara , Mehrabi Manoosh , Keshtkar Abbas Ali , Oroojan Ali Akbar , Sivandzadeh Gholam Reza 
Published: July 2022

AbstractBackgroundThis study aimed to systematically review and pool data regarding the alterations in the clinical course of inflammatory bowel disease (IBD) following liver transplantation (LT).MethodsRelevant prospective and retrospective observational studies were identified by searching databases and gray literature through December 2020. Random-effects models were used to calculate the pooled frequency of IBD patients with disease course alterations (“improved,” “unchanged,” or “aggravated”) after LT and the corresponding 95% confidence intervals (CIs).ResultsTwenty-five studies met our inclusion criteria, reporting the outcomes in 2 or 3 categories. In the analysis of studies with 3-category outcomes (n = 13), the pooled frequencies of patients with improved, unchanged, or aggravated IBD course after LT were 29.4% (95% CI, 16.9% to 41.9%), 51.4% (95% CI, 45.5% to 57.3%), and 25.2% (95% CI, 15.6% to 34.8%), respectively. Subgroup analyses revealed that patients with ulcerative colitis (UC), younger age at LT, or shorter duration of follow-up were more likely to have an improved disease course. Moreover, higher IBD exacerbation estimates were observed in studies with a low risk of bias. In the analysis of studies with 2-category outcomes (n = 12), the pooled frequencies of patients with improved/unchanged or aggravated IBD course were 73.6% (95% CI, 62.2% to 85.0%) and 24.1% (95% CI, 15.1% to 33.2%), respectively. The cumulative incidence of an exacerbated IBD course following LT was 0.22 (95% CI, 0.16-0.29; P &lt; .001).ConclusionWe conclude that IBD activity remains unchanged (or improved/unchanged) in most IBD patients following LT. Furthermore, IBD type, age, and follow-up length can influence the IBD course after LT.
A C0 finite element method for the biharmonic problem with Navier boundary conditions in a polygonal domain
Authors: Li Hengguang , Yin Peimeng , Zhang Zhimin 
Published: July 2022

Abstract
In this paper we study the biharmonic equation with Navier boundary conditions in a polygonal domain. In particular, we propose a method that effectively decouples the fourth-order problem as a system of Poisson equations. Our method differs from the naive mixed method that leads to two Poisson problems but only applies to convex domains; our decomposition involves a third Poisson equation to confine the solution in the correct function space, and therefore can be used in both convex and nonconvex domains. A $C^0$ finite element algorithm is in turn proposed to solve the resulting system. In addition, we derive optimal error estimates for the numerical solution on both quasi-uniform meshes and graded meshes. Numerical test results are presented to justify the theoretical findings.
Outcomes of Patients with Burns Associated with Home Oxygen Therapy: An Institutional Retrospective Review
Authors: Yoon Joshua S , Khoo Kimberly H , Puthumana Joseph S , Pérez Rivera Lucas R , Keller Patrick R , Lagziel Tomer , Cox Carrie A , Caffrey Julie , Galiatsatos Panagis , Hultman C Scott 
Published: July 2022

Abstract
Home oxygen therapy (HOT) burns carry high morbidity and mortality. Many patients are active smokers, which is the most frequent cause of oxygen ignition. We conducted a retrospective review at our institution to characterize demographics and outcomes in this patient population. An IRB-approved single-institution retrospective review was conducted for home oxygen therapy burn patients between July 2016 and January 2021. Demographic and clinical outcome data were compared between groups. We identified 100 patients with oxygen therapy burns. Mean age was 66.6 years with a male to female ratio of 1.3:1 and median burn surface area of 1%. In these patients, 97% were on oxygen for COPD and smoking caused 83% of burns. Thirteen were discharged from the emergency department, 35 observed for less than 24 hours, and 52 admitted. For admitted patients, 69.2% were admitted to the ICU, 37% required intubation, and 11.5% required debridement and grafting. Inhalational injury was found in 26.9% of patients, 3.9% underwent tracheostomy, and 17.3% experienced hospital complications. In-hospital mortality was 9.6% and 7.7% were discharged to hospice. 13.5% required readmission within 30 days. Admitted patients had significantly higher rates of admission to the ICU, intubation, and inhalational injury compared to those that were not admitted (P &lt; .01). Most HOT-related burns are caused by smoking and can result in significant morbidity and mortality. Efforts to educate and encourage smoking cessation with more judicious HOT allocation would assist in preventing these unnecessary highly morbid injuries.
Biomodifying the ‘natural’: from Adaptive Regulation to Adaptive Societal Governance
Authors: Mourby Miranda , Bell Jessica , Morrison Michael , Faulkner Alex , Li Phoebe , Bicudo Edison , Webster Andrew , Kaye Jane 
Published: July 2022

Abstract
Biomodifying technologies—such as gene editing, induced pluripotent stem cells, and bioprinting—are being developed for a wide range of applications, from pest control to lab-grown meat. In medicine, regulators have responded to the challenge of evaluating modified ‘natural’ material as a therapeutic ‘product’ by introducing more flexible assessment schemes. Attempts have also been made to engage stakeholders across the globe on the acceptable parameters for these technologies, particularly in the case of gene editing. Regulatory flexibility and stakeholder engagement are important, but a broader perspective is also needed to respond to the potential disruption of biomodification. Our case-study technologies problematize basic ideas—such as ‘nature’, ‘product’, and ‘donation’—that underpin the legal categories used to regulate biotechnology. Where such foundational concepts are rendered uncertain, a socially responsive and sustainable solution would involve exploring evolutions in these concepts across different societies. We suggest that the global observatory model is a good starting point for this ‘Adaptive Societal Governance’ approach, in which a self-organizing network of scholars and interested parties could carry out the multi-modal (meta)analyses needed to understand societal constructions of ideas inherent to our understanding of ‘life’.
Transformation or Conformation? The English Broadside Ballad and the Playhouse, 1797–1844
Authors: Bartlett Georgina 
Published: July 2022

ABSTRACT
This article considers the migration of theatre music into the English broadside ballad tradition from 1797 to 1844, the most prolific era of the broadside during which the fierce professional competitors John Pitts (active 1797–1844) and James Catnach (active 1813–41) operated their presses in the Seven Dials, near London’s patent theatres. The discussion is based on the findings of a database that was constructed systematically to cross-reference 520 theatrical works from the London stage with 11,432 broadside songs of this period from the Bodleian Library’s broadside collections. By considering the scale and mechanism of the migration of theatre music into the broadside tradition—as well as examining the characteristics of the songs themselves—this article explores the effects of theatre music on nineteenth-century street literature and song, evaluating the ways in which theatre songs transformed the broadside tradition, and the ways in which they conformed to it.
Retinopathy of Prematurity Screening Exams, Adverse Events, and Music Therapy: A Case Series
Authors: Bakouros Susan , Rarey Kristin , Evered John 
Published: July 2022

Abstract
Preterm (PT) infants are routinely screened for retinopathy of prematurity (ROP). After ROP screening exams, PT infants are at risk for adverse events (AEs), including apnea and bradycardia (ABD), respiratory decompensation, infection, and gastrointestinal complications. Music therapy (MT) has been shown to improve overall physiologic stability in PT infants in the neonatal intensive care unit (NICU). In this case series, a board-certified music therapist used a music therapy protocol during 47 ROP screening exams. The study’s purpose was to explore the potential effects of NICU MT on AEs linked to ROP screening. No infant had any respiratory decompensation, new infection, or other complications. The rate of ABD after screening exams was low. MT during ROP screening appears safe and feasible. We hypothesize that MT might prevent ABD associated with ROP screening, a theory that could be effectively studied in a randomized controlled trial.
Variations in energy of cyclotron lines with double structures formed in a line-forming region with bulk motion in accreting X-ray pulsars
Authors: Nishimura Osamu 
Published: July 2022

Abstract
We show that variations in the energy of a cyclotron resonant scattering feature with luminosity can be explained by considering a variation of the bulk velocity of infalling matter in the two-dimensional structure of an accretion column. Variations in the energy of a cyclotron line with luminosity are computed by taking into account the variation in gradient of the bulk velocity with luminosity in a line-forming region. We mainly discuss the positive correlation between the energy of the cyclotron line $E_{cyc}$ at the fundamental and the luminosity as observed in the spectra of GX 304−1, A0535+262, and Vela X-1, considering a change in gradient of the bulk velocity in the line-forming region with luminosity in addition to a change of altitude of the line-forming region with luminosity. Consequently, we demonstrate that the change in the observed line energy with luminosity can be successfully reproduced by a variation in bulk velocity due to radiation pressure as well as the altitude of an accretion mound.
Preferred Communication Strategies Used by Physical Therapists in Chronic Pain Rehabilitation: A Qualitative Systematic Review and Meta-Synthesis
Authors: Chapman Chelsea R , Woo Nathan T , Maluf Katrina S 
Published: July 2022

Abstract

Objective
Lack of clarity regarding effective communication behaviors in chronic pain management is a barrier for implementing psychologically informed physical therapy approaches that rely on competent communication by physical therapist providers. This study aimed to conduct a systematic review and meta-synthesis to inform the development of a conceptual framework for preferred communication behaviors in pain rehabilitation.

Methods
Ten databases in the health and communication sciences were systematically searched for qualitative and mixed-method studies of interpersonal communication between physical therapists and adults with chronic pain. Two independent investigators extracted quotations with implicit and explicit references to communication and study characteristics following Standards for Reporting Qualitative Research and Strengthening the Reporting of Observational Studies in Epidemiology guidelines. Methodological quality for individual studies was assessed with Critical Appraisal Skills Programme, and quality of evidence was evaluated with GRADE-CERQual. An inductive thematic synthesis was conducted by coding each quotation, developing descriptive themes, and then generating behaviorally distinct analytical themes.

Results
Eleven studies involving 346 participants were included. The specificity of operationalizing communication terms varied widely. Meta-synthesis identified 8 communication themes: (1) disclosure-facilitating, (2) rapport-building, (3) empathic, (4) collaborative, (5) professional accountability, (6) informative, (7) agenda-setting, and (8) meta-communication. Based on the quality of available evidence, confidence was moderate for 4 themes and low for 4 themes.

Conclusion
This study revealed limited operationalization of communication behaviors preferred by physical therapists in chronic pain rehabilitation. A conceptual framework based on 8 communication themes identified from the literature is proposed as a preliminary paradigm to guide future research.

Impact
This proposed evidence-based conceptual framework for preferred communication behaviors in pain rehabilitation provides a framework for clinicians to reflect on their own communication practices and will allow researchers to identify if and how specific communication behaviors impact clinical outcomes.
Development of a Novel Care Rehabilitation Pathway for Post-COVID Conditions (Long COVID) in a Provincial Health System in Alberta, Canada
Authors: Manhas Kiran Pohar , O’Connell Petra , Krysa Jacqueline , Henderson Isabel , Ho Chester , Papathanassoglou Elisavet 
Published: July 2022

Abstract

Objective
The purpose of this study was to describe the development and composition of a codesigned, multidisciplinary, integrated, systematic rehabilitation framework for post-COVID conditions (PCC) that spans the care continuum to streamline and standardize rehabilitation services to support persons with PCC in Alberta, Canada.

Methods
A collaborative, consensus-based approach was used involving 2 iterative provincial taskforces in a Canadian provincial health system. The first taskforce (59 multidisciplinary stakeholders) sought to clarify the requisite facets of a sustainable, provincially coordinated rehabilitation approach for post-COVID rehabilitation needs based on available research evidence. The second taskforce (129 multidisciplinary stakeholders) translated that strategy and criteria into an operational framework for provincial implementation. Both taskforces sought to align with operational realities of the provincial health system.

Results
The summation of this collaborative consensus approach resulted in the Provincial Post COVID-19 Rehabilitation Response Framework (PCRF). The PCRF includes 3 care pathways across the care continuum specifically targeting in-hospital care, continuing care, and community-based care with 3 key elements: (1) the use of specific symptom screening and assessment tools to systematically identify PCC symptoms and functional impairments, (2) pathways to determine patients’ rehabilitation trajectory and guide their transition between care settings, and (3) self-management and education resources for patients and providers.

Conclusion
The PCRF aligns with international mandates for novel, codesigned, multidisciplinary approaches to systematically address PCC and its myriad manifestations across the care continuum. The PCRF allows for local adaptation and highlights equity considerations, allowing for further spread and scale provincially, nationally, and internationally.

Impact
The PCRF is a framework for health systems to ensure consistent identification, assessment, and management of the rehabilitation needs of postacute and chronic PCC. Rehabilitation providers and health systems can build from the PCRF for their local communities to reduce unmet needs and advance the standardization of access to rehabilitation services for persons with PCC.
Patient-Centered Goals After Lumbar Spine Surgery: A Secondary Analysis of Cognitive-Behavioral–Based Physical Therapy Outcomes From a Randomized Controlled Trial
Authors: Coronado Rogelio A , Master Hiral , Bley Jordan A , Robinette Payton E , Sterling Emma K , O’Brien Michael T , Henry Abigail L , Pennings Jacquelyn S , Vanston Susan W , Myczkowski Brittany , Skolasky Richard L , Wegener Stephen T , Archer Kristin R 
Published: July 2022

AbstractObjectiveThe purpose of this study was to examine the association between goal attainment and patient-reported outcomes in patients who engaged in a 6-session, telephone-based, cognitive-behavioral–based physical therapy (CBPT) intervention after spine surgery.MethodsIn this secondary analysis of a randomized trial, data from 112 participants (mean age = 63.3 [SD = 11.2] years; 57 [51%] women) who attended at least 2 CBPT sessions (median = 6 [range = 2–6]) were examined. At each session, participants set weekly goals and used goal attainment scaling (GAS) to report goal attainment from the previous session. The number and type of goals and percentage of goals met were tracked. An individual GAS t score was computed across sessions. Participants were categorized based on goals met as expected (GAS t score ≥ 50) or goals not met as expected (GAS t score &lt; 50). Six- and 12-month outcomes included disability (Oswestry Disability Index), physical and mental health (12-Item Short-Form Health Survey), physical function (Patient-Reported Outcomes Measurement Information System), pain interference (Patient-Reported Outcomes Measurement Information System), and back and leg pain intensity (numeric rating scale). Outcome differences over time between groups were examined with mixed-effects regression.ResultsParticipants set a median of 3 goals (range = 1–6) at each session. The most common goal categories were recreational/physical activity (36%), adopting a CBPT strategy (28%), exercising (11%), and performing activities of daily living (11%). Forty-eight participants (43%) met their goals as expected. Participants who met their goals as expected had greater physical function improvement at 6 months (estimate = 3.7; 95% CI = 1.0 to 6.5) and 12 months (estimate = 2.8; 95% CI = 0.04 to 5.6). No other outcome differences were noted.ConclusionsGoal attainment within a CBPT program was associated with 6- and 12-month improvements in postoperative physical functioning.ImpactThis study highlights goal attainment as an important rehabilitation component related to physical function recovery after spine surgery.
The Political Economy of Local Governments’ Requests for Permission to Override Central Fiscal Limitations: Insights from Israel
Authors: Kimhi Omer , Beeri Itai , Reingewertz Yaniv 
Published: July 2022

AbstractCentral governments often restrict municipalities’ ability to raise or reduce taxes, but, in many jurisdictions, municipalities can ask the central government’s permission to set aside these limitations. Using an Israeli dataset, we explore this prevalent, yet unexplored, mechanism we call Permission to Override (PtO). We find that in Israel, at least, the central government’s approval and rejection of these permission requests seem to be equitable and non-political. However, despite the central neutrality, municipalities with lower socio-economic status and fewer political connections tend not to submit requests. Municipalities are also reluctant to submit requests before elections and tend to submit them only afterwards. These socio-economic and political biases may create inequalities and hinder a successful use of the PtO mechanism. We discuss the limited use of this mechanism (requests amount to approximately 0.6 percent of the total property tax income) and its shortcomings and draw conclusions from the Israeli case study.
What Is Holding Us Together? David Hume, Edgar Allan Poe and the Problem of Association
Authors: Kronfeld Maya 
Published: July 2022

Abstract
Poe’s experimental fiction revitalizes Hume’s ambivalent empiricism, the complexities of which were sometimes obscured in the philosopher’s nineteenth-century American reception. Poe’s ‘Murders in the Rue Morgue’ broaches formally the question of how one thought leads to another, while ‘The Man that Was Used Up’ stages the question of what grounds the unity of one’s thoughts. Reading both tales together exposes the scope and limits of an associationist paradigm often traced back to Hume. But reading Hume through Poe’s verbal art reveals that Hume’s ‘mitigated scepticism’ about personal identity is more difficult to grapple with, and potentially more devastating for Western Reason, than the modes of scepticism that more comfortably entered the English canon. In ‘Rue Morgue’, Detective Dupin’s presumption to reconstruct fully the narrator’s train of thought may be the real locus of the tale’s horror. In the ‘Man that Was Used Up’, the heroic General A.B.C. Smith disintegrates on the floor into a talking ‘bundle’ that parodically literalizes Hume’s most famous metaphor in the Treatise. Hume’s bundle thus reappears in Poe as the proto-surrealist ‘terminus’ of a reductive explanation that has become physically real. To say with Hume that the mind is a ‘fiction’ is not to deny the goings-on of mental phenomena, but to attempt a much more challenging claim: that our minds conceptualize themselves out of their own limited nature, but not in a way that necessarily accords with that nature. If Hume brings out the parody in Poe, we might also say that Poe amplifies the irony in Hume.