bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of pivotal genes with prognostic evaluation value in lung adenocarcinoma by bioinformatics analysis
Authors: Wang Yushan , Zhao Yanhui , Wang Yizhen , Ma Cuiping , Gu Yuchao , Peng Xiufa , Zhang Chunling , Wang Ye 
Published: August 2022

Abstract
Lung cancer remains the leading cause of cancer morbidity and mortality worldwide, and over diagnosis causes various unnecessary losses in patients' lives and health. How to more effectively screen lung cancer patients and their potential prognostic risk become the focus of our current study. By analyzing the LUAD expression profile in The Cancer Genome Atlas (TCGA), we constructed a weighted gene co-expression network using differentially expressed genes (DEGs) to find the key modules and pivotal genes. A COX proportional risk regression model based on the least absolute shrinkage and selection operator (LASSO) was used to assess the predictive value of the model for the prognosis of LUAD patients. A total of 4107 up-regulated DEGs and 2022 down-regulated DEGs were identified in this study, and enrichment analysis showed that these analyzes were associated with the extracellular matrix of cells and adhesion. Ten gene markers consisting of LDHA, TOP2A, UBE2C, TYMS, TRIP13, EXO1, TTK, TPX2, ZWINT, and UHRF1 were established by extracting the central genes in the key modules, and the upregulation of these genes was accompanied by an increased prognostic risk of patients. Among them, high expression of LDHA, TRIP13, TTK in LUAD was associated with shorter overall survival and could be used as independent prognostic factors to participate in metabolic processes such as tumor NAD. The present study provides a powerful molecular target for the study of LUAD prognosis and provides a theoretical basis for the diagnosis and treatment of LUAD and the development of targeted inhibitors.
Towards Providing a Novel Security Framework for the Internetof Things (NSF-IoT)
Authors: S.M.H. Sithi Shameem Fathima , Vidhyalakshmi M. , C Priya , N Subbulakshmi , Thomas Samraj Lawrence 
Published: August 2022

Abstract
This proliferation of smart services and applications caused by IoT and its major role in Industry4.0 revolution will cause the number of connected devices to reach to 20 to 50 billion by 2020.As inany other network, the IoT networks are also susceptible to various cyber security attacks. Theattacks may happen in i) perception layer which comprises of the sensing devices that collect dataii) the network layer through which the data is routed to the application layer or iii) the applicationlayer where the big data is processed to evolve intelligent decisions to constitute for the smartness inthe IoT system. Though currently available significant research outcomes could adapt to counteractthe security issues in the application and network layers, the security concerns in the sensinglayer deserves due interest. This is because the sensing layer has to provide authentication andconfidentiality in order to ensure that the data is received from the authenticated sensors in a securemanner. If the sensed data corresponds to that of individuals, then the concerns of privacy also arise.The existing solutions to provide device authentication and confidentiality rely on extrinsic solutionlike the block chain for device authentication, confidentiality and privacy. This is because thesensing layer comprises mostly of low memory devices on which it is difficult to add software-basedauthentication, data confidentiality and privacy algorithms. Light weight cryptography solutionsare available but again it is not suitable for the miniscule sensors. The heterogeneity of the sensingdevice types and sensors adds momentum to the said device level challenges. Hence, there isneed for the development of device intrinsic hardware based solution(s) to constitute for deviceauthentication, data confidentiality, integrity and privacy preservation of the sensed data using thePhysically Unclonable function(PUF) and Field Programmable Gateway Arrays (FPGA)whichare designed based on Bio-Inspired techniques thereby rendering the perception layer resilient toattacks. The paper is focusing on the meaning of each security goal to the providing solutionfor inbuilt IoT security system. The study finds various IoT security attacks layer by layer andidentifying IoT security goals and their rapport with other layers. Later, we propose a solutionfor hardware inbuilt IoT security and then performed a comprehensive analysis on concerningcost-saving. The results shows that the proposed system reduces cost by 60.16% and and assures61.36% of trust.
Characteristics of hydrogen and oxygen isotopes and their differences of different water bodies in the subalpine shrubland of the eastern Qilian Mountains in China
Authors: Zhang Yue , Jia Wenxiong , Yang Le , Xiong Hui , Zhang Fuhua , Zhang Miaomiao , Lan Xin 
Published: August 2022

Abstract
As the main bodies of water transformation, precipitation, soil water, plant water, river water and ground water play important roles in water cycle. Based on stable isotope values of five types of water bodies collected in the subalpine shrubland of the eastern Qilian Mountains from May to October in 2019, the characteristics of hydrogen and oxygen isotopes and their differences of different water bodies were studied. The results showed that the slope of the local meteorological water line (LMWL) was lower (7.63 < 8) and the intercept was higher (14.06 > 10) than those of the global meteorological water line (GMWL), indicating that the precipitation isotopes were enriched by evaporative fractionation. Stable isotope values of soil water mainly recharged by precipitation vary significantly and seasonally (summer > autumn > spring) and decreased with increasing of soil depth, where there were some differences in different aspects. Plant transpiration was more intense than evaporations of other water bodies, thus stable isotope values of plant water were the highest among five water bodies. There were differences in stable isotope values among plant species at different stages in growing season (germination and leaf development stage > flowering and fruiting stage > leaf drop decline stage), and those of plant water were higher on semi-shady slopes than on semi-sunny slopes. Stable isotope values of tributary streams were higher than those of main streams, and there were seasonal differences between them (main streams: autumn > spring > summer, tributaries: autumn > summer > spring). Among five types of water bodies, the fluctuation variation of stable isotope values was the greatest in precipitation and the smallest in ground water. This study can help to improve the understanding of ecohydrological processes in subalpine shrubland and provide a reference basis for the ecological management in the Qilian Mountains and the rational utilization of water resources in the Shiyang River Basin.
Identification of genetic characteristics in pediatric epilepsy with focal cortical dysplasia type 2 using deep whole-exome sequencing
Authors: Xu Yan , Zhao Rui , Wang Ming , Wang Xin-hua , Wang Yi , Li Hao , Ma Yang-yang , Wu Bing-bing , Zhou Yuan-feng 
Published: August 2022

Abstract
Background:
Objective
Focal cortical dysplasia type 2 (FCD2) is malformations of cortical development that constitutes a common cause of pediatric focal epilepsy. Germline or somatic variants in the mammalian target of rapamycin (mTOR) signaling pathway genes are pathogenesis of FCD2. In this study, whole-exome deep sequencing was performed on dysplastic cortex from focal epilepsy in children to explore genetic characteristic in FCD2.
Methods
Resected core lesions of FCD2 were confirmed by pathology and peripheral blood from 11 patients were collected. Deep whole-exome sequencing (> 500X) was performed on derived genomic DNA, germline or somatic variants in brain- specific genes were analyzed and identified.
Results
In 11 patients, a heterozygous pathogenic germline variant of DEPDC5 was identified in one case, while somatic variants were found in four brain samples. The frequencies of the somatic variant allele were 2.52%~5.12%. Somatic variants in AKT3, TSC2 and MTOR (mTOR signaling pathway genes) were found in three samples. Besides, one somatic variant was detected in MED12 which not been reported to associated with FCD2.
Conclusion
Our study expanded the variant spectrum in the mTOR-GATOR pathway, also detected a somatic variant in MED12 which was potentially associated with FCD 2.
Mantle Cell Lymphoma Presenting with Primary Neurolymphomatosis and Cutaneous Involvement: A Case Report
Authors: Gera Kriti , Kreher Margaret Ann , Kunzler Elaine , Missall Tricia A. , Franke Aaron J. 
Published: August 2022

Abstract
Introduction:
Neurolymphomatosis (NL) is an extremely rare manifestation of lymphoproliferative and hematologic malignancies characterized by direct neoplastic infiltration of the peripheral nervous system, and ubiquitously portends poor outcomes with dismal survival. This challenging and infrequent clinical entity is most commonly associated with B-cell non-Hodgkin lymphomas (NHLs), with only a few cases of NL as a presentation of mantle cell lymphoma (MCL) ever reported. The heterogenous clinical features of NL overlap with several more common neurologic sequalae of NHL, a challenge which often leads to delays, and even misdiagnosis, of this aggressive condition. As a diagnostically challenging, rapidly progressive rare disease, there is a paucity of evidence describing the natural clinical course of NL, diagnostic algorithms, prognosis, patient outcomes data, and most crucially, optimal therapeutic management strategies. Aggressive lymphomas may also infiltrate the skin causing secondary cutaneous B-cell lymphoma, an exceptionally rare manifestation of MCL. To the authors’ knowledge, this is the first reported case in the literature describing a patient with MCL presenting with primary neurolymphomatosis and secondary cutaneous MCL.
Case presentation:
A 73-year-old man recently diagnosed with MCL developed painless, ascending weakness, which progressed over weeks to near-complete paralysis. MRI of the lumbar spine was consistent with neurolymphomatosis. Concurrently, he developed erythematous papules and plaques on the face, chest, and proximal upper extremities. Skin biopsy was consistent with cutaneous infiltration of MCL. Treatment with HD-MTX plus R-CHOP therapy produced minimal improvement, and he died three weeks after initiation of therapy.
Conclusions
Neurolymphomatosis and secondary cutaneous MCL are each very rare manifestations of MCL. Rapid, aggressive infiltration of both the nerve roots and skin by MCL represents unusually high-grade disease. This case underscores the importance of high clinical suspicion for neurolymphomatosis in any subtype of lymphoma showing aggressive features. Prognosis is poor, and early intervention is crucial to minimize progression.
Heating Up the Planet – A Fresh Hot Look at Global Warming
Authors: Lemos Francisco , Lemos Maria Amélia 
Published: August 2022

Abstract
Global warming is an inescapable phenomenon that seems to be unquestionably linked with Human activity, in particular with the way Humanity uses energy, and constitutes one of the most important challenges we are facing in the near future. The occurrence of global warming is being linked to the emissions of gases with a greenhouse effect, that is, gases that can trap heat in the atmosphere and, thus, induce an imbalance between the energy the Earth receives and the one that it is able to emit back into space. This imbalance induces an accumulation that is credited as responsible for the warming of the atmosphere. In this paper, we take a different view, based on a thermodynamic analysis, of the overall world’s energy production/consumption system and raise the issue that the warming of the atmosphere is likely to be affected by the energy system in more ways than this imbalance between energy intake and energy release due to the emissions of greenhouse gases and that it may be directly influenced by the generation and use of energy itself. The main conclusion that we reach from our calculations is that the amount of energy that is currently being produced on a global scale can actually make a significant contribution, if not the major contribution, to the current increase in atmospheric temperature.
Monitoring and Control of Faults in the Automation Industry Using Soft Sensors and Ant Colony Optimization Fourier Transform Perceptron with Multiple Layers
Authors: Anupong Wongchai , Abourehab Mohammed A.S. , Ahmed Mohammed Altaf 
Published: August 2022

Abstract
In modern industrial processes, various types of soft sensors are used, which play essential roles in process monitoring, control and optimization. Emerging new theories, advanced techniques and the information infrastructure have enabled the elevation of the performance of soft sensing. Once soft sensors are designed, a mechanism to maintain or update these models is highly desirable in industry. This paper proposed novel technique in monitoring and control optimization of soft sensors in automation industry for fault detection. Here fault detection has been carried out using Probabilistic Multi-Layer Fourier Transform Perceptron (PMLFTP). The input collected plant data has been pre-processed for removal of samples containing null values.Then fault detection and diagnosis process have been carried out based on probability of the data with Fourier transform-based detection and multi-layer perceptron-based diagnosis of the fault in the manufacturing process. Then controlling of data in soft sensors has been optimized using auto-regression based ant colony optimization (AR_ACO) which has effect in increasing the production of industry automatically. The experimental results have been carried out in terms of computational rate of 40%, QoS of 78%, RMSE of 45%, fault detection rate of 90%, control optimization of 93% has been obtained for various historical data-based evaluations.
Mathematical Analysis of the Transmission Dynamics of Syphilis in China
Authors: Zhao Tiantian , Liao Ying , Jiao Haiyan 
Published: August 2022

Abstract
Background
Syphilis, a sexually transmitted infectious disease caused by the bacterium treponema pallidum, and it remains a significant cause of morbidity in many developing countries. Mathematical models of the transmission dynamics of sexually transmitted infections have provided insights of relevance both to the interpretation of observed epidemiological patterns and to the design of control programs.
Goal and Study Design:
Based on the syphilis data in China from 2010 to 2020, the SEIRS dynamical model was established to provide theoretical support and quantitative basis for syphilis control in China.
Results
First of all, Based on the data of syphilis in China from 2010 to 2020, the parameterizations and model calibration are carried out. The fitting results are in good agreement with the data. And then, we calculate the basic reproduction number R0, and R0 = 1.0556, which means that the syphilis epidemic will continue to be prevalent in China. Moreover, sensitivity analysis shows that the progression rate from incubating to infection (w), treatment rate in infection stage (γ), and treatment rate in incubating stage (α) play a critical role in mitigating the syphilis outbreaks.
Conclusion
These results can help us gain insights into the epidemiology of syphilis and provide guidance for the public health authorities to implement health education programs.
Presence and role of viruses in anaerobic digestion of food waste under environmental variability
Authors: Fan Lu , Peng Wei , Duan Haowen , Lü Fan , Zhang Hua , He Pinjing 
Published: August 2022

Abstract
Background
The interaction among microorganisms in anaerobic digestion of food waste (ADFW) reactors achieves the degradation of organics and the recycling of energy. As an important component of the microorganisms in ADFW, viruses were rarely explored. Furthermore, little is known about how viruses affect methanogenesis.
Results
Here, we recovered thousands of viral sequences from five full-scale ADFW reactors. Gene-sharing networks indicated that ADFW contained a large number of unexplored anaerobic-specific viruses. Moreover, viral communities in different full-scale reactors exhibited both commonalities and heterogeneities. Lab-scale dynamic analysis in typical scenarios further suggested that viruses have similar kinetic characteristics to their prokaryotic hosts. By associating with the putative hosts, the vast majority of bacteria and archaea phyla can be infected by viruses. Viruses may influence prokaryotic ecological niches and thus methanogenesis by infecting key functional microorganisms such as sulfate-reducing bacteria, syntrophic acetate oxidizing bacteria, and methanogens. Metabolic predictions of viruses revealed that viruses can facilitate the metabolism of sulfur and fatty acids by enhancing host metabolic capacity in key steps and participate in typical methanogenic pathways to promote methane production.
Conclusions
Overall, our results expand on the diversity of viruses in the ADFW systems and point out two ways of viral manipulation of ADFW biochemical processes.
A Order based Content-Based 3D Model Retrieval proposal
Authors: Amorim Thiago Kobashigawa , Biscaro Helton Hideraldo 
Published: August 2022

Abstract
In computer graphics, Content-Based Retrieval (CBR) is a database system that consists of receiving an object as input and returning a list of similar objects. Although originally conceived for images, CBR systems can work with objects of another nature such as sounds, and three-dimensional models , represented as geometrical meshes, transporting CBR systems to contexts other than images To assess the proximity between the meshes, some techniques consist of performing mathematical transformations of the meshes into feature vectors and calculating the distance relationship between these vectors. In this work, we built a prototype of a 3D CBR system that uses an order relation, instead of a distance function, as a similarity function between the objects. Furthermore , we propose the use of an order in R n that we call Extended Lexicographical Order (ELO), which seeks to take into account all the information present in the vectors to be compared. We compared our prototype not only with the traditional distance functions but also with more classical R n order relations such as lexicographical and revlex. We also use two types of descrip-tors, a spectral descriptor based on compressed sensing theory and a harmonic spherical-based descriptor. In all cases, our prototype performed better when compared to traditional techniques.
Somatostatin is key to explaining the long-term effect of anatomical rearrangements after sleeve gastrectomy on glucose metabolism
Authors: Pérez-Arana Gonzalo-Martín , González-Domínguez Álvaro , Visiedo-García Francisco-Jose , Díaz-Gómez Alfredo , Reyes José Bancalero-De los , Camacho-Ramírez Alonso , Ribelles-García Antonio , Almorza-Gomar David , Gracia-Romero Manuel , Prada-Oliveira José-Arturo 
Published: August 2022

Abstract
Background. Sleeve gastrectomy (SG) is one of the most commonly performed bariatric surgeries is able to treat diabetes (T2DM) better than many drugs. The mechanisms that underlie this phenomenon remains unclear. We propose that somatostatin (SST), isoforms, SST-14 and SST-28, are key to explaining the pathophysiological mechanisms behind T2DM improvement after SG. Methods. We underwent surgeries on three groups of Wistar rats -fasting (FC), surgery control (Sham), and SG groups-. We measured plasma levels of glucose, insulin, SST-14 and SS-28 at several weeks after surgery, islet somatostatin receptor (SSTR) and cell populations at short and long-term after surgery. We performed a Pasireotide (SST-28 analogue) infusion assay in another group of rats to confirm the influence of SST-28 plasma levels on the delta-cell population. Results. We found an elevation of the insulin response after surgery in SG animals but a decrease in insulin response in the long-term with a loss of beta cell mass. An increase in duodenal SST-28-producing cells in the duodenum and a loss of pancreatic SST-14-producing cells was measured after SG but not in controls. The expression of SSTR-5 in delta-cell populations from every group and the ability of the Pasireotide infusion assay to decrease the delta-cell population indicate the effect of SST-28 plasma levels on delta-cell maintenance. Conclusion. After SG begins with a compensatory response in the duodenum, the depletion of beta cell mass after losing the brake that constitutes SST-14 at the paracrine level. This process may explain the percentage of T2DM relapse after SG.
‘Are Routine Post-Discharge Diuretics Necessary After Pediatric Cardiac Surgery?’
Authors: Penk Jamie S , de Faria Guilherme Baptista , Collins Catherine A , CPNP-AC Lindsay M Jackson , Porlier Avaliese L , Petito Lucia , Marino Bradley 
Published: August 2022

Abstract
Hypothesis: We hypothesized that a single regimen of no or limited diuretics post-discharge after pediatric cardiac surgery for patients with two ventricles is not inferior to prolonged diuretics for prevention of readmission for pleural effusion. Material and Methods: A prospective, one-armed, safety non-inferiority trial with historical controls was performed at a single center, quaternary, children’s hospital. Inclusion criteria were children aged 3 months to 18 years after pediatric cardiac surgery resulting in a two- ventricle repair between 7/2020 and 7/2021. Eligible patients were compared with patients from a five-year historical period (selected using a database search). The intervention was that “regular risk” patients received no diuretics and pre-specified “high risk” patients received five days of twice per day furosemide at discharge. Results: 61 subjects received the intervention. None were readmitted for pleural effusions, though 1 subject was treated for a symptomatic pleural effusion with outpatient furosemide. The study was halted after an interim analysis demonstrated that 4 subjects were readmitted with pericardial effusion during the study period versus 2 during the historical control (2.9% versus 0.2%, p = 0.003). Conclusions: We found no evidence that limited post-discharge diuretics results in an increase in readmissions for pleural effusions. This conclusion is limited as not enough subjects were enrolled to definitively show that this strategy is not inferior to the historical practice. There was a small, but statistically significant, increase in readmissions for pericardial effusions after implementation of this study protocol.