bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internet of Things enabled real time cold chain monitoring in a container port
Authors: Cil Ahmet Yunus , Abdurahman Dini , Cil Ibrahim 
Published: May 2022

Abstract
Purpose
Seaports are regarded as significant actors in global logistics and supply chains since a large part of the cargoes carried over the globe are being processed there. When the cold chain broken down during transport and storage in the ports, the humidity, nutrition, temperature and time conditions to be required for the growth of the bacteria occur, and rapid reproduction occurs and the properties of the products are rapidly deteriorating. It is imperative that especially medicines, some chemical substances and foodstuffs need to be transported without breaking the cold chain in the logistics. The monitoring and control of the temperature and humidity level is important in the time period between the loading of these containers in special areas in ports, the loading of freight in open areas, or the loading of freight on roads and railway carriages. For this reason, precise monitoring and control of the system is vital in the port logistics management.

Method
In this study, an IoT-enabled system is designed for Container Ports by developing software, interface and equipment that will enable remote monitoring of temperature, humidity and other necessary key status parameters.

Findings
The developed IoT-based system provides audible and visual warning, e-mail and SMS communication, similar to a monitoring screen such as a heart graph monitor, when the instant values of the refrigerated container are transmitted to the database, when the defined upper and lower values are approached. All these data and major change information are archived in the database and retrospective situation analysis and data analysis can be performed.

Conclusion
Using technologies such as Wireless Sensor Network (WSN) and RFID, an IoT-enabled Cold Chain Logistics system has been proposed that provides real-time monitoring of products in containers at ports, providing DS services to logistics providers and customers. In this context, it was explained how the ambient parameter values were collected in real time using WSN and IEEE 802.15.4, how the collected data was sent to the server via the GSM gateway. In the port scenario, activation devices such as IEEE 802.15.4 and RFID were modeled using the OPNET simulator. The developed model was carried out in accordance with the principles of EPCglobal Gen 2. With the proposed approach, smart solutions provide a smarter flow of information. The results show that IoT- enabled cold chain systems have a great potential for managing, monitoring, receiving and determining abnormal events related to temperature-sensitive products in real time.
A 3D printed model of the female pelvis for practical education of gynecological pelvic examination
Authors: Kiesel Matthias , Beyers Inga , Kalisz Adam , Joukhadar Ralf , Wöckel Achim , Herbert Saskia-Laureen , Curtaz Carolin , Wulff Christine 
Published: May 2022

Abstract
Background
Pelvic palpation is a core component of every Gynecologic examination. It requires vigorous training, which is difficult due to its intimate nature, leading to a need of simulation. Up until now, there are mainly models available for mere palpation which do not offer adequate visualization of the concerning anatomical structures. In this study we present a 3D printed model of the female pelvis. It can improve both the practical teaching of gynecological pelvic examination for health care professionals and the spatial understanding of the relevant anatomy.

Methods
We developed a virtual, simplified model showing selected parts of the female pelvis. 3D printing was used to create a physical model.

Results
The life-size 3D printed model has the ability of being physically assembled step by step by its users. Consequently, it improves teaching especially when combining it with commercial phantoms, which are built solely for palpation training. This is achieved by correlating haptic and visual sensations with the resulting feedback received.

Conclusion
The presented 3D printed model of the female pelvis can be of aid for visualizing and teaching pelvic anatomy and examination to medical staff. 3D printing provides the possibility of creating, multiplying, adapting and sharing such data worldwide with little investment of resources. Thus, an important contribution to the international medical community can be made for training this challenging examination.
Physical Activity and Quality of Life in Malaysian Breast Cancer Survivors: A Longitudinal Study
Authors: Islam Tania , Lin Lee Yi , Danaee Mahmoud , Taib Nur Aishah 
Published: May 2022

PURPOSE Regular physical activity (PA) after a diagnosis of breast cancer(BC) is associated with reduced morbidity and a higher quality of life (QOL). Investigate the association of PA and QOL among Malaysian BC survivors in this prospective cohort study. METHODS A total of, 133 BC women were interviewed at baseline, one year, and three-year after diagnosis of BC in a tertiary referral center in Klang Valley. The Global Physical Activity Questionnaire and the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire were used to measure PA and QOL of the survivors. A generalized estimating equation was performed to examine the association of PA and QOL longitudinally. RESULTS The mean age was 56.89 (± 10.56) years old, and the majority were Chinese (50.4%). At baseline, 48.1% of patients were active and it declined to 39.8% at one year, and 35.3% at third year. Three years after diagnosis (Adjusted Odds Ratio [AOR]: 1.74, P = .021), being underweight (AOR: 3.43, P = .004) and being Malay (AOR: 1.86, P = .042) were found to be significant associating factors with inactivity. Overall, the QOL was observed to decrease over the years. Global health status, physical and cognitive functioning had a significant declining trend from baseline to three years ( P = < 0.001, P = < 0.001 and P = .001 respectively). For symptom scales, patients experienced more fatigue over time too ( P = .006). When analysing the association of PA and QOL, being active significantly improve role functioning ( P = .022). At one year, being active also significantly reduced constipation symptoms ( P = .048). CONCLUSION The findings showed that BC survivors in Malaysia had inadequate PA levels at diagnosis and further decreased over time. Their QOL had a declining trend, but PA was found to improve constipation symptoms and role functioning. Thus, it is essential to promote PA throughout their follow-ups with more focus on Malay ethnicity.
A Qualitative Exploration of the Acceptability of an Online Web Application to Promote Breast and Cervical Cancer Screening in Primary Care Settings in Malaysia
Authors: Cheong Ai Theng , Lee Ping Yien , Ghazali Sazlina Shariff , Rashid Aneesa Abdul , Ng Chirk Jenn , Teo Chin Hai , Rajoo Yamuna , Ching Ong Siu , Jaganathan Maheswari , Ho Bee Kiau , Teo Soo-Hwang 
Published: May 2022

PURPOSE In Malaysia, breast and cervical are the most common and third most common cancers respectively. They are associated with high morbidity and mortality in women. With the rapid development of information communication technology and widespread adoption of mobile devices in low to middle-income countries, online web applications (app) could be one of the strategies to engage patients to go for screening programs. METHODS Fifteen (15) health care professionals (HCPs) and 25 patients visiting the primary care were interviewed through focus groups and in-depth interviews to determine the acceptability of an online web application to promote screening for these cancers. RESULTS Both HCPs and patients expressed that an online web app would be beneficial to the technology-savvy group such as the younger generation. However, the older-aged group could benefit from it with some assistance. The primary consideration identified is the user's information technology (IT) competency. Participants suggested that the use of easy-to-use features (eg, download method), visually easy-to-understand formats (eg, less text and more pictures, videos), and provision of support to navigate the web app may be critical to ensure good uptake of a web app on screening. Contents of the app suggested to be included were: individual risk assessment for the users of the app, benefits of screening, information addressing patients' barriers such as fear, embarrassment, logistic, and cost issues. CONCLUSION The findings of our study may be useful as a guide to developing an online web app to promote breast and cervical cancer screening.
ANPEP: A Potential Regulator of Tumor Cell—Immune Metabolic Interactions in Prostate Cancer of Men of African Descent
Authors: Elkenawi Asmaa , Awasthi Shivanshu , Serna Amparo , Dhillon Jasreman , Yamoah Kosj 
Published: May 2022

PURPOSE Prostate cancer (PCa) is the leading cause of male cancer deaths in Africa. In USA, African American men (AA) experience higher mortality rate compared to European American men (EA). While socioeconomics factors contribute toward these disparities, distinct molecular mechanisms in AA remain important drivers. For example, in previous work, we discovered that PCa form AA men harbored a significantly higher expression of Aminopeptidase N (ANPEP) as compared with EA. Aminopeptidase N regulates immune cell function and mediates tumor cell migration but its role in PCa remains uninvestigated. METHODS We explored ANPEP expression related to a range of genomic classifiers in multiple datasets. We then prospectively examined the differentially expressed genes in PCa tissues collected from 120 AA and 120 EA patients enrolled on the VANDAAM clinical trial. We further correlated ANPEP expression with various signatures related to immune and metabolic activity. We also experimentally examined the expression of ANPEP in different components of tumor microenvironment. RESULTS In the VANDAAM study, ANPEP represents the top differentially expressed gene between AA and EA men. Our data driven approach revealed that ANPEP correlates with signature of cholesterol transport and androgen signaling. Interestingly, these signatures dominate in PCa with high macrophage infiltration. Deconvolution of immune cell content using computational approaches indeed demonstrated that only AA patients with high ANPEP expression significantly accumulated high content of inflammatory macrophages. Further experimental findings showed that ANPEP indeed represents a marker of tumor-associated macrophages, a type of immune cells known to contribute to PCa progression. CONCLUSION We have identified ANPEP as a macrophage-related gene with a potential role in cholesterol metabolism and AR signaling in AA. Future work will focus on the functional role of ANPEP activity in the tumor immune microenvironment using Liquid chromatography-high resolution mass spectrometry and explants derived from AA and EA PCa patients.
Impact of the Covid-19 Pandemic on Prostate Cancer Investigation and Diagnosis in the Brazilian Public Health System (SUS)
Authors: Kieling Lucas , Estacia da Silveira Izadora Bouzeid , Seixas de Sá Beltramo Luiza , Hass Lopes Yasmin Ricarte , Lech Gabriele Eckerdt , Marques da Silva Laura Tibola , Mateus Danna Gomes 
Published: May 2022

PURPOSE Prostate cancer was the second most deadly type of cancer in males in Brazil in 2019. Therefore, early diagnosis is fundamental to reduce its morbimortality. Diagnosis is essentially confirmed by prostate biopsy. The overload on health systems caused by the coronavirus pandemic has strongly affected the investigation process in Brazilian public healthcare (SUS). Under these circumstances, we aim to expose the effects of COVID-19 in the screening and diagnosis of prostate cancer performed by SUS. METHODS A cross-sectional design of data collected from DATASUS's Hospital Information System. The study analyzes absolute numbers of prostate biopsies and diagnosis of prostate cancer registered between January and July in 10 years (2011-2020) which were comparatively evaluated. Statistical analysis was performed to assess the number of procedures compared over the years. RESULTS The number of prostate biopsies in Brazil, through the Public Health System (SUS), between January 2011 and December 2019, was 393,678 with a yearly average of 43,742 procedures. In 2020, there was a 27.23% decrease, meaning only 31,829 procedures. In agreement with that, a decrease of 49.71%, 33.73%, 37.25% and 40.76% on prostate cancer diagnosis was reported in the months of April, May, June and July, respectively, when comparing 2019 and 2020. The total number of prostate cancer diagnoses also suffered a decrease of 27.32% between the years of 2019 and 2020, going from 41,981 procedures to only 30,511. CONCLUSION The reduction on the number of prostate cancer diagnosis is evident and is going to affect the morbimortality of the patients who haven't had access to the health system during the covid 19 pandemic. It is fundamental to know the amount of damming on those diagnoses to propose measures to prevent the worst outcomes, reducing avoidable deaths.
Coverage and Socio-Economic Inequalities in Breast Cancer Screening in Low- and Middle-Income Countries: Analysis of Demographic and Health Surveys Between 2010 and 2019
Authors: Abila Derrick Bary , Kangoma Grace , Kisuza Ruth Ketty , Wasukira Sulaiman Bugosera , Ainembabazi Provia , Wabinga Henry 
Published: May 2022

PURPOSE The World Health Organisation (WHO) launched the Global Breast Cancer Initiative (GBCI) in 2020 intending to reduce global breast cancer mortality by 2.5% per year until 2040, thereby averting an estimated 2.5 million deaths. In this study, we aimed to determine the coverage and socio-economic inequalities in the screening for breast cancer over one decade before the establishment of the GBCI. METHODS For each country, using STATA 16 software and sampling weights, we analyzed the datasets of Demographic and Health Surveys (DHS) that included questions on breast cancer screening and were conducted between 2010 and 2019 in low- and middle-income countries. We included women aged 15-49 years and considered screening using breast self-examination (BSE), clinical breast examination (CBE), and mammography. Absolute and relative inequalities were determined using the Slope Index of Inequality (SII) and Concentration Index (CIX) respectively. RESULTS A total of 18 surveys from 13 countries were included in this study. Only six surveys from five countries measured the rates of screening by mammography which ranged from 5.58% to 12.96%. Considering screening using any method, the proportion that had ever screened for breast cancer ranged from 2.53% to 60.21%. Higher rates of screening were seen in upper-middle-income countries compared to low-income countries. For the CIX for screening using any method, the inequalities were pro-rich in all the countries except the Philippines where it was pro-poor with a CIX of –2.84 ( P value .015). For the CIX and SII for screening using mammography, the inequalities were pro-rich in all the countries. CONCLUSION There exist socio-economic disparities in the coverage of breast cancer using mammography, clinical breast examination, and breast self-exam. There is a need to address these disparities to achieve the targets of breast cancer control by the GBCI.
Accelerating Learning Health Systems Using Alicanto Collaboration Platforms
Authors: Quintana Yuri , Einstein David , Joyce Robin , Lyu Andrew , El Sayed Nuha , Andrews Carolyn , Rebbeck Tim 
Published: May 2022

PURPOSE Global health challenges require systematic approaches that bring together a wide range of stakeholders and experts unevenly distributed worldwide. We saw an even greater need to find novel ways to collaborate during the pandemic due to limited in-person meetings and travel restrictions. The purpose of this project is to accelerate collaborations in learning health systems with online technologies to improve communication, education, and knowledge management. METHODS We developed Alicanto Cloud, an online collaboration platform for healthcare professionals to support learning health systems. Alicanto aims to help groups communicate, share educational resources, discuss complex clinical cases across institutions and countries. Alicanto provides multiple ways for users to create synchronous and asynchronous discussions. Alicanto was developed by the BIDMC Division of Clinical Informatics in collaboration with local and international colleagues with a specific focus on global health and capacity building. RESULTS Alicanto is being used worldwide for cancer, pediatrics, and diabetes collaborations. Online communities use Alicanto to standardize care guidelines, disseminate clinical care best practices, provide online training, conduct virtual tumor boards, and improve knowledge management. Beth Israel Deaconess Medical Center has used Alicanto to connect 13 hospitals and has completed over 600 virtual tumor board case discussions. Dana-Farber Cancer Institute uses Alicanto as an online cancer training network for sub-Saharan Africa. Doctors from Joslin Clinic have used Alicanto to create a global diabetes education network. We will discuss lessons learned in implementing these networks and best practices for accelerating the process of evidence synthesis to dissemination and capacity building. CONCLUSION Communities of practice can accelerate their communications and collaborations with the appropriate tools and platforms tailored to their network needs. Further research is needed to understand the optimal ways to create sustained growth and support of communities of practice in learning health systems.
Clinical Regression of High-Grade Cervical Intraepithelial Neoplasia Is Associated With Absence of FAM19A4/miR124-2 DNA Methylation (CONCERVE Study)
Authors: Kremer Wieke W. , Dick Stèfanie , Heideman Daniëlle A.M. , Steenbergen Renske D.M. , Bleeker Maaike C.G. , Verhoeve Harold R. , van Baal W. Marchien , van Trommel Nienke , Kenter Gemma G. , Meijer Chris J.L.M. , Berkhof Johannes 
Published: May 2022

PURPOSE Cervical screening can prevent cancer by detection and treatment of cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3). Screening also results in considerable overtreatment because many CIN2/3 lesions show spontaneous regression when left untreated. In this multicenter longitudinal cohort study of women with untreated CIN2/3, the prognostic value of FAM19A4/miR124-2 methylation was evaluated for clinical regression. PATIENTS AND METHODS Women with CIN2/3 were prospectively followed for 24 months. Surgical excision was replaced by a wait-and-see policy. FAM19A4/miR124-2 methylation was evaluated on all clinician-collected samples and self-collected samples collected at baseline. Every 6 months, human papillomavirus (HPV) testing and cytology were conducted on a clinician-collected sample, and a colposcopic examination was performed by a gynecologist to exclude progression. At the final study visit, two biopsies were taken. Clinical regression was defined as histologically confirmed absence of CIN2+ or an HPV-negative clinician-collected sample with normal cytology. Regression incidences were estimated using the Kaplan-Meier method. RESULTS One hundred fourteen women (median age, 30 years; range, 20-53 years) were included, 80 of whom were diagnosed with CIN2 and 34 with CIN3. During the study, 65.8% of women (75/114) did not receive surgical treatment. Women with a negative FAM19A4/miR124-2 result on the baseline clinician-collected sample showed more clinical regression (74.7%) than women with a positive methylation result (51.4%, P = .013). Regression in women with a negative FAM19A4/miR124-2 methylation test was highest when cytology was atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion (88.4%) or HPV16 was negative (85.1%). CONCLUSION Most women with untreated CIN2/3 and a negative baseline FAM19A4/miR124-2 methylation test showed clinical regression. Methylation, in combination with cytology or HPV genotyping, can be used to support a wait-and-see policy in women with CIN2/3.
Final Analysis of 3 Versus 6 Months of Adjuvant Oxaliplatin and Fluoropyrimidine-Based Therapy in Patients With Stage III Colon Cancer: The Randomized Phase III ACHIEVE Trial
Authors: Yoshino Takayuki , Oki Eiji , Misumi Toshihiro , Kotaka Masahito , Manaka Dai , Eto Tetsuya , Hasegawa Junichi , Takagane Akinori , Nakamura Masato , Kato Takeshi , Munemoto Yoshinori , Nakamura Fumitaka , Bando Hiroyuki , Taniguchi Hiroki , Sakamoto Yasuhiro , Shiozawa Manabu , Nishi Masayasu , Horiuchi Tetsuya , Yamagishi Hisakazu , Sakamoto Junichi , Mizushima Tsunekazu , Ohtsu Atsushi , Mori Masaki 
Published: May 2022

PURPOSE The phase III ACHIEVE trial conducted in Japan was one of six prospective studies included in the International Duration Evaluation of Adjuvant Therapy collaboration, which explored whether 3 months of adjuvant fluorouracil, leucovorin, and oxaliplatin (FOLFOX) or capecitabine and oxaliplatin (CAPOX) therapy would be noninferior to 6 months of treatment in patients with curatively resected stage III colon cancer. We report the final analyses of survival and long-term safety. PATIENTS AND METHODS Eligible patients were randomly assigned (1:1) to either 3 or 6 months of adjuvant chemotherapy (modified [m]FOLFOX6 or CAPOX, as selected by the treating physician). Random assignment was stratified according to number of involved lymph nodes, center, regimen, primary site, and age. The primary end point was disease-free survival, assessed in the modified intention-to-treat population. Overall survival (OS) was a secondary end point. RESULTS The modified intention-to-treat population comprised 1,291 patients: 641 in the 6-month treatment group and 650 in the 3-month treatment group. Median follow-up for this analysis was 74.7 months. Five-year OS rates were comparable: 87.0% in the 3-month treatment group and 86.4% in the 6-month treatment group (hazard ratio, 0.91; 95% CI, 0.69 to 1.20; P = .51). Subgroup analysis of OS did not reveal a significant interaction between baseline characteristics and treatment duration. Peripheral sensory neuropathy lasting longer than 5 years was more common in the 6- compared with 3-month treatment group (16% v 8%, respectively), and in those receiving mFOLFOX6 compared with CAPOX (14% v 11%, respectively). CONCLUSION In Asian patients, shortening adjuvant therapy duration from 6 to 3 months did not compromise efficacy and reduced the rate of long-lasting peripheral sensory neuropathy. In this setting, 3 months of CAPOX therapy is an appropriate adjuvant treatment option.