bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of Incidence Trend of Influenza-Like Illness in Wuhan Based on ARIMA Model
Authors: Meng Pai , Huang Juan , Kong Deguang 
Published: July 2022

Objective. The autoregressive integrated moving average (ARIMA) model has been widely used to predict the trend of infectious diseases. This paper is aimed at analyzing the application of the ARIMA model in the prediction of the incidence trend of influenza-like illness (ILI) in Wuhan and providing a scientific basis for the prediction and prevention of influenza. Methods. The weekly ILI data of two influenza surveillance sentinel hospitals in Wuhan City published on the website of the National Influenza Center of China were collected, and the ARIMA model was used to model the data from 2014 to 2020, to predict and verify the ILI data in 2021. Results. The optimal model for the incidence trend of ILI in Wuhan was ARIMA

1
,
1
,
1

, the residuals were in line with the white noise sequence (

0.018
<
Ljung
‐
Box

Q
<
30.695

,

P
>
0.05

), and the relative error between the predicted value and the actual value was small, which all proved the model was practical. Conclusion. ARIMA

1
,
1
,
1

can effectively simulate the short-term incidence trend of ILI in Wuhan.
Proteomic Analysis Reveals the Vital Role of Synaptic Plasticity in the Pathogenesis of Temporal Lobe Epilepsy
Authors: Qian Xu , Ding Ji-Qiang , Zhao Xin , Sheng Xin-Wen , Wang Zhao-Rui , Yang Qi-xing , Zheng Jing-Jun , Zhong Jia-Gui , Zhang Teng-Yue , He Shu-Qiao , Ji Wei-Dong , Li Wei , Zhang Mei 
Published: July 2022

Temporal lobe epilepsy (TLE) is a chronic neurological disorder that is often resistant to antiepileptic drugs. The pathogenesis of TLE is extremely complicated and remains elusive. Understanding the molecular mechanisms underlying TLE is crucial for its diagnosis and treatment. In the present study, a lithium-pilocarpine-induced TLE model was employed to reveal the pathological changes of hippocampus in rats. Hippocampal samples were taken for proteomic analysis at 2 weeks after the onset of spontaneous seizure (a chronic stage of epileptogenesis). Isobaric tag for relative and absolute quantization (iTRAQ) coupled with liquid chromatography-tandem mass spectrometry (LC–MS/MS) technique was applied for proteomic analysis of hippocampus. A total of 4173 proteins were identified from the hippocampi of epileptic rats and its control, of which 27 differentially expressed proteins (DEPs) were obtained with a

fold

change
>
1.5

and

P
<
0.05

. Bioinformatics analysis indicated 27 DEPs were mainly enriched in “regulation of synaptic plasticity and structure” and “calmodulin-dependent protein kinase activity,” which implicate synaptic remodeling may play a vital role in the pathogenesis of TLE. Consequently, the synaptic plasticity-related proteins and synaptic structure were investigated to verify it. It has been demonstrated that CaMKII-α, CaMKII-β, and GFAP were significant upregulated coincidently with proteomic analysis in the hippocampus of TLE rats. Moreover, the increased dendritic spines and hippocampal sclerosis further proved that synaptic plasticity involves in the development of TLE. The present study may help to understand the molecular mechanisms underlying epileptogenesis and provide a basis for further studies on synaptic plasticity in TLE.
BRCA1-Dependent and Independent Recruitment of PALB2–BRCA2–RAD51 in the DNA Damage Response and Cancer
Authors: Foo Tzeh Keong , Xia Bing 
Published: July 2022

AbstractThe BRCA1–PALB2–BRCA2 axis plays essential roles in the cellular response to DNA double-strand breaks (DSB), maintenance of genome integrity, and suppression of cancer development. Upon DNA damage, BRCA1 is recruited to DSBs, where it facilitates end resection and recruits PALB2 and its associated BRCA2 to load the central recombination enzyme RAD51 to initiate homologous recombination (HR) repair. In recent years, several BRCA1-independent mechanisms of PALB2 recruitment have also been reported. Collectively, these available data illustrate a series of hierarchical, context-dependent, and cooperating mechanisms of PALB2 recruitment that is critical for HR and therapy response either in the presence or absence of BRCA1. Here, we review these BRCA1-dependent and independent mechanisms and their importance in DSB repair, cancer development, and therapy. As BRCA1-mutant cancer cells regain HR function, for which PALB2 is generally required, and become resistant to targeted therapies, such as PARP inhibitors, targeting BRCA1-independent mechanisms of PALB2 recruitment represents a potential new avenue to improve treatment of BRCA1-mutant tumors.
Are the Pieces Starting to Come Together for Management of Desmoid Tumors?
Authors: Greene Anna C. , Van Tine Brian A. 
Published: July 2022

SummaryDesmoid tumor research is changing how desmoid tumors are managed with the prospective documentation that growing desmoid tumors spontaneously regress one third of the time. Patient partnership through the Desmoid Research Tumor Foundation and academia is leading to rapid advancement in desmoid tumor biology understanding and treatment.See related articles by Colombo et al., p. 4027, Nathenson et al., p. 4092, and Penel et al., p. 4105
SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
Authors: Lukinović Valentina , Hausmann Simone , Roth Gael S. , Oyeniran Clement , Ahmad Tanveer , Tsao Ning , Brickner Joshua R. , Casanova Alexandre G. , Chuffart Florent , Benitez Ana Morales , Vayr Jessica , Rodell Rebecca , Tardif Marianne , Jansen Pascal W.T.C. , Couté Yohann , Vermeulen Michiel , Hainaut Pierre , Mazur Pawel K. , Mosammaparast Nima , Reynoird Nicolas 
Published: July 2022

Abstract

Small cell lung cancer (SCLC) is the most fatal form of lung cancer, with dismal survival, limited therapeutic options, and rapid development of chemoresistance. We identified the lysine methyltransferase SMYD3 as a major regulator of SCLC sensitivity to alkylation-based chemotherapy. RNF113A methylation by SMYD3 impairs its interaction with the phosphatase PP4, controlling its phosphorylation levels. This cross-talk between posttranslational modifications acts as a key switch in promoting and maintaining RNF113A E3 ligase activity, essential for its role in alkylation damage response. In turn, SMYD3 inhibition restores SCLC vulnerability to alkylating chemotherapy. Our study sheds light on a novel role of SMYD3 in cancer, uncovering this enzyme as a mediator of alkylation damage sensitivity and providing a rationale for small-molecule SMYD3 inhibition to improve responses to established chemotherapy.

Significance:
SCLC rapidly becomes resistant to conventional chemotherapy, leaving patients with no alternative treatment options. Our data demonstrate that SMYD3 upregulation and RNF113A methylation in SCLC are key mechanisms that control the alkylation damage response. Notably, SMYD3 inhibition sensitizes cells to alkylating agents and promotes sustained SCLC response to chemotherapy.
This article is highlighted in the In This Issue feature, p. 2007
Impact of the
RNF213
p.R4810K Variant on Endovascular Therapy for Large‐Vessel Occlusion Stroke
Authors: Yoshimoto Takeshi , Tanaka Kanta , Koge Junpei , Saito Satoshi , Yamagami Hiroshi , Nakaoku Yuriko , Ogata Soshiro , Nishimura Kunihiro , Yamaguchi Eriko , Chiba Tetsuya , Kawakami Daisuke , Shiozawa Masayuki , Kamogawa Naruhiko , Ohta Tsuyoshi , Satow Tetsu , Inoue Manabu , Hattori Yorito , Washida Kazuo , Kataoka Hiroharu , Chung Jong‐Won , Bang Oh Young , Toyoda Kazunori , Koga Masatoshi , Maruyama Hirofumi , Ihara Masafumi 
Published: July 2022

Background
We investigated the impact of the ring finger protein 213 p.R4810K variant, a founder variant for moyamoya disease in East Asians, on endovascular therapy outcomes in patients with acute anterior‐circulation large‐vessel occlusion stroke in comparison with noncarriers.

Methods
Of the consecutive patients with ischemic stroke admitted to our institute from 2011 to 2021, patients who underwent endovascular therapy for acute occlusion of the intracranial internal carotid artery or M1 segment of the middle cerebral artery were included. Outcomes were instant reocclusion, final modified Thrombolysis in Cerebral Infarction reperfusion ≥2b, and early reocclusion. Instant reocclusion was defined as the occurrence of reocclusion during the procedure, and early reocclusion was defined as reocclusion detected on magnetic resonance angiography within 2 weeks after the confirmation of successful reperfusion.

Results

Of the 277 patients analyzed (128 women; median age, 76 years), 10 patients (3.6%) carried the ring finger protein 213 p.R4810K variant. Variant carriers were younger (
P
=0.01) and more frequently had intracranial atherosclerotic disease‐related large‐vessel occlusion as a cause of acute large‐vessel occlusion (
P
<0.001) compared with noncarriers. Variant carriers showed a higher rate of instant reocclusion (70.0% versus 5.6%;
P
<0.001), but there were no significant intergroup differences in the final modified Thrombolysis in Cerebral Infarction ≥2b reperfusion rate between carriers and noncarriers (100.0% versus 81.6%, respectively;
P
=0.22). Early reocclusion was more frequent in variant carriers compared with noncarriers (60.0% versus 0.4%;
P
<0.001).

Conclusions
Instant and early reocclusions were more frequent in variant carriers who underwent endovascular therapy for acute anterior‐circulation large‐vessel occlusion compared with noncarriers.
FiNN: A toolbox for neurophysiological network analysis
Authors: Scherer Maximilian , Wang Tianlu , Guggenberger Robert , Milosevic Luka , Gharabaghi Alireza 
Published: July 2022

Abstract
Recently, neuroscience has seen a shift from localist approaches to network-wide investigations of brain function. Neurophysiological signals across different spatial and temporal scales provide insight into neural communication. However, additional methodological considerations arise when investigating network-wide brain dynamics rather than local effects. Specifically, larger amounts of data, investigated across a higher dimensional space, are necessary. Here, we present FiNN (Find Neurophysiological Networks), a novel toolbox for the analysis of neurophysiological data with a focus on functional and effective connectivity. FiNN provides a wide range of data processing methods and statistical and visualization tools to facilitate inspection of connectivity estimates and the resulting metrics of brain dynamics. The Python toolbox and its documentation are freely available as Supporting Information. We evaluated FiNN against a number of established frameworks on both a conceptual and an implementation level. We found FiNN to require much less processing time and memory than other toolboxes. In addition, FiNN adheres to a design philosophy of easy access and modifiability, while providing efficient data processing implementations. Since the investigation of network-level neural dynamics is experiencing increasing interest, we place FiNN at the disposal of the neuroscientific community as open-source software.
Hypothalamic effective connectivity at rest is associated with body weight and energy homeostasis
Authors: Voigt Katharina , Andrews Zane B. , Harding Ian H. , Razi Adeel , Verdejo-García Antonio 
Published: July 2022

Abstract
Hunger and satiety drive eating behaviours via changes in brain function. The hypothalamus is a central component of the brain networks that regulate food intake. Animal research parsed the roles of the lateral hypothalamus (LH) and medial hypothalamus (MH) in hunger and satiety, respectively. Here, we examined how hunger and satiety change information flow between human LH and MH brain networks, and how these interactions are influenced by body mass index (BMI). Forty participants (16 overweight/obese) underwent two resting-state functional MRI scans while being fasted and sated. The excitatory/inhibitory influence of information flow between the MH and LH was modelled using spectral dynamic causal modelling. Our results revealed two core networks interacting across homeostatic state and weight: subcortical bidirectional connections between the LH, MH and the substantia nigra pars compacta (prSN), and cortical top-down inhibition from fronto-parietal and temporal areas. During fasting, we found higher inhibition between the LH and prSN, whereas the prSN received greater top-down inhibition from across the cortex. Individuals with higher BMI showed that these network dynamics occur irrespective of homeostatic state. Our findings reveal fasting affects brain dynamics over a distributed hypothalamic-midbrain-cortical network. This network is less sensitive to state-related fluctuations among people with obesity.
Structural connectome constrained graphical lasso for MEG partial coherence
Authors: Wodeyar Anirudh , Srinivasan Ramesh 
Published: July 2022

Abstract
Structural connectivity provides the backbone for communication between neural populations. Since axonal transmission occurs on a millisecond time scale, measures of M/EEG functional connectivity sensitive to phase synchronization, such as coherence, are expected to reflect structural connectivity. We develop a model of MEG functional connectivity whose edges are constrained by the structural connectome. The edge strengths are defined by partial coherence, a measure of conditional dependence. We build a new method—the adaptive graphical lasso (AGL)—to fit the partial coherence to perform inference on the hypothesis that the structural connectome is reflected in MEG functional connectivity. In simulations, we demonstrate that the structural connectivity’s influence on the partial coherence can be inferred using the AGL. Further, we show that fitting the partial coherence is superior to alternative methods at recovering the structural connectome, even after the source localization estimates required to map MEG from sensors to the cortex. Finally, we show how partial coherence can be used to explore how distinct parts of the structural connectome contribute to MEG functional connectivity in different frequency bands. Partial coherence offers better estimates of the strength of direct functional connections and consequently a potentially better estimate of network structure.
MIA-QSAR analysis of an increased data set of 1,3,4-oxa/thiadiazole nematicides to enhance the molecular diversity and agrochemical candidacy
Authors: Licona Jessica S.F. , de Faria Adriana C. , Pereira Ingrid V. , Daré Joyce K. , Freitas Matheus P. 
Published: July 2022

Summary
Tylenchulus semipenetrans nematodes affect citrus crops and may develop resistance to commercially available nematicides. In this sense, two series of 1,3,4-oxa- and thiadiazole compounds have been recently synthesised and tested as nematicides against T. semipenetrans, demonstrating promising results. We report herein a molecular modelling study that combines these two series of congeneric compounds to form a single and enhanced data set. The chemical structures of these compounds were correlated with the respective nematicidal activities (pLC50) using multivariate image analysis (MIA) descriptors in quantitative structure-activity relationship (QSAR) analysis. The partial least squares (PLS) regression yielded reliable and predictive models (, , and ). Therefore, novel 1,3,4-oxa- and thiadiazole derivatives were proposed and a few of them exhibited predicted nematicidal performance better than those of the parent compounds.
Inspecting Ships Autonomously under Port State Jurisdiction: Towards Sustainability and Biodiversity in the EU
Authors: Derrig Ríán 
Published: July 2022

Abstract
This article examines the possibility of autonomous inspection robots being used to undertake inspection tasks conducted on the basis of port State jurisdiction in European Union (EU) Member States’ ports. A brief overview of technical research concerning such robots is offered. The article then outlines the EU legal framework concerning port State jurisdiction, and contextualises this legal landscape by recalling the history of attempts at the EU and international level to regulate in response to maritime disasters since the 1980s. Based on a close reading of the Port State Control Directive, alongside analysis of the aims pursued and policy options proposed in the context of the European Commission’s significant ongoing work on a review of this instrument, it is clear that the adoption of autonomous inspection technologies could offer significant benefits, permitting more efficient completion of existing inspection tasks and potentially changing what is and is not considered feasible in inspection scenarios.
Digital Platforms in Contemporary India: The Transformation of Quotidian Life Worlds
Authors: Mukherjee Rahul , Nizaruddin Fathima 
Published: July 2022

Abstract
The introduction to the special issue on ‘Digital Platforms in Contemporary India: Transformation of Quotidian Life Worlds’ focuses on the ways in which everyday interactions in contemporary India have changed since the arrival of digital platforms. Locating these changes within their specific contexts, the essays in the special issue examine the new circulatory assemblages and representational tropes that emerge through interactions between diverse platforms and their various users. In particular, the essays trace the different ways in which bodies, mobilities, and platforms are entangled in everyday life in an unfolding phenomenon. This introduction outlines the new spatiotemporal shifts catalyzed by the platformization of everyday activities in India, drawing connections among the various essays in the special issue. The introduction attempts to map these shifts as part of a two-way process, which acknowledges that the resulting transformations also have the potential for reimagining the existing logic of platforms.
#delhimetro on Instagram: Digital Media and Mobility Practices before and during the COVID-19 Pandemic
Authors: Sharma Sonali 
Published: July 2022

Abstract
India has the highest number of Instagram users in the world. This article examines Instagram, the mobility, and the digital media practices of Delhi Metro commuters before and during the COVID-19 pandemic. In particular, it looks at their photography of everyday lived experiences, their mediated interactions with one another, and the visible-invisible infrastructure in the city. It draws attention to the complexity of digital production, personal archiving, and circulation networks at play. Foregrounding the changing ‘geographies of social media’, a qualitative, digital ethnographic approach analyses these images’ visual, social, and contextual aspects. Also, a range of convergent practices related to individuals, places, and socio-cultural-political-economic-technological realities influence the images. Eventually, a narrative emerges on how these metro travellers inhabit offline and online public spaces, exchange cultural capital, and perform the affective, mediated negotiation of the city.
The Ny-Ålesund Aerosol Cloud Experiment (NASCENT): Overview and First Results
Authors: Pasquier J. T. , David R. O. , Freitas G. , Gierens R. , Gramlich Y. , Haslett S. , Li G. , Schäfer B. , Siegel K. , Wieder J. , Adachi K. , Belosi F. , Carlsen T. , Decesari S. , Ebell K. , Gilardoni S. , Gysel-Beer M. , Henneberger J. , Inoue J. , Kanji Z. A. , Koike M. , Kondo Y. , Krejci R. , Lohmann U. , Maturilli M. , Mazzolla M. , Modini R. , Mohr C. , Motos G. , Nenes A. , Nicosia A. , Ohata S. , Paglione M. , Park S. , Pileci R. E. , Ramelli F. , Rinaldi M. , Ritter C. , Sato K. , Storelvmo T. , Tobo Y. , Traversi R. , Viola A. , Zieger P. 
Published: July 2022

Abstract
The Arctic is warming at more than twice the rate of the global average. This warming is influenced by clouds, which modulate the solar and terrestrial radiative fluxes and, thus, determine the surface energy budget. However, the interactions among clouds, aerosols, and radiative fluxes in the Arctic are still poorly understood. To address these uncertainties, the Ny-Ålesund Aerosol Cloud Experiment (NASCENT) study was conducted from September 2019 to August 2020 in Ny-Ålesund, Svalbard. The campaign’s primary goal was to elucidate the life cycle of aerosols in the Arctic and to determine how they modulate cloud properties throughout the year. In situ and remote sensing observations were taken on the ground at sea level, at a mountaintop station, and with a tethered balloon system. An overview of the meteorological and the main aerosol seasonality encountered during the NASCENT year is introduced, followed by a presentation of first scientific highlights. In particular, we present new findings on aerosol physicochemical and molecular properties. Further, the role of cloud droplet activation and ice crystal nucleation in the formation and persistence of mixed-phase clouds, and the occurrence of secondary ice processes, are discussed and compared to the representation of cloud processes within the regional Weather Research and Forecasting Model. The paper concludes with research questions that are to be addressed in upcoming NASCENT publications.
ɛ-caprolactone and pentaerythritol derived oligomer for rigid polyurethane foams preparation
Authors: Walczak Małgorzata , Lubczak Jacek 
Published: July 2022

Copolymerization of pentaerythritol with five equivalents of ɛ-caprolactone leads to tetra-functional branched oligomer terminated with hydroxyl groups. The product was characterized by elemental analysis, IR and NMR spectroscopy, gel permeation chromatography and physical methods to determine viscosity, density and surface tension. The oligomer was then used to obtain rigid polyurethane foam. The foam was characterized by physicochemical methods to determine: apparent density, water uptake, polymerization shrinkage, heat conductance coefficient, thermal stability, compression strength and biodegradation. The foam obtained from this oligomer have the properties similar to classic rigid polyurethane foams but enhanced thermal resistance. It can stand long time heating at 175°C, while its compression strength increases upon thermal exposure. The foam and oligomer are biodegradable; the oligomer is fully decomposed within 28 days in soil, while the foam obtained from it is in the same conditions degradable up to 28% of initial mass.
Does Cognitive Therapy Change the Early Maladaptive Schemas in Individuals with Alcohol Dependence? Evidence from a Randomized Controlled Trial
Authors: Singh Geeta , Kaloiya Gauri Shanker , Dhawan Anju , Mishra Ashwani Kumar , Balhara Yatan Pal Singh 
Published: July 2022

Background: Although early maladaptive schemas (EMSs) have been suggested as potential vulnerability markers for alcohol dependence (AD), there is less emphasis on addressing these schemas in substance abuse treatment programs. We thus aimed to examine the change in schemas in response to cognitive therapy in individuals with AD. Methods: In this an open-label randomized controlled study, individuals with alcohol dependence syndrome (ADS, n = 84) were randomized to the intervention group ( n = 45), which received six cognitive therapy sessions combined with treatment as usual (TAU), or the control group ( n = 39), which was on TAU only. Participants were assessed on the measures of EMSs, alcohol use severity, and perceived stress at baseline and posttreatment. Results: The intervention group showed significant improvement in 5 out of 18 EMSs, that is, emotional deprivation, defectiveness, self-sacrifice, unrelenting standard, and negativity, compared to the control group, at the end of the treatment. There was a significant between-group effect for perceived stress but not for alcohol use severity. Conclusion: EMSs can be changed with cognitive therapy in individuals with AD and could be a crucial area to address in treatment programs. Further studies with long-term follow-up are warranted.  The trial was registered with the Clinical Trials Registry—India (CTRI/2015/12/006441) on December 17, 2015.