bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pro-angiogenic activity of isofuran in rat brain endothelial cells
Authors: Zhu Tang , Zhang Jingxia , Wang Xiangjiang , Lin Zhiping 
Published: April 2022

Abstract
Background: Isofurans (IsoFs) are a series of novel discovered lipid peroxidation products, which are found in some oxidation-injured disorders. Oxidative damage is a major pathological feature of abnormal vascularization diseases. This study is focused on the investigation of angiogenic property of IsoF. The alteration on cellular proliferation, migration, and apoptosis by an IsoF were also detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, coverslip migration assay, and TUNEL assay. Furthermore, cellular calcium release and extracellular regulated protein kinases (ERK) 1/2 activation by IsoF were analyzed. RT-PCR was carried out to detect some angiogenesis-related gene expression induced by IsoF. Results: MTT stain assay indicated that 1mM IsoF had the most bioactivity in RBECs. IsoF significantly promoted cellular proliferation and migration and remarkably decreased staurosporine-induced apoptosis by TUNEL assay in the RBECs. Moreover, IsoF activated extracellular regulated protein kinases (ERK)1/2 and trigged calcium release. RT-PCR examination indicated that IsoF up-regulated tumor necrosis factor (TNF)a, angiopoietin-1 receptor (Tie2), and vascular endothelial growth factor (VEGF)-A, but did not interfere with caspase 2 and VEGF-C in the RBECs.Conclusion: IsoF has pro-angiogenic activity via promotion of cellular proliferation/migration and prohibition of cellular apoptosis. Calcium release and ERK1/2 phosphorylation may be involved in the signaling of the IsoF-induced up-regulation of TNFa, Tie2, and VEGF-A, which could be the molecular mechanism of the pro-angiogenic activity of the IsoF.
Environmental regulation and high-quality economic growth——Quasi-natural experimental evidence from China
Authors: Zhang Yanbo , Li Xiang 
Published: April 2022

Abstract
The relationship between environmental regulation and economic growth is difficult to reconcile, resulting in the "involutional" dilemma of environmental governance by local governments. The panel data of Chinese A-share listed industrial companies during the period between 2010 and 2019, this paper manually collected data on environmental protection interview and central environmental protection inspection, and empirically investigated the impact of both on the high-quality economic growth of companies using the difference-in-difference method. The results indicate that first, both environmental protection interview and central environmental protection inspection significantly promote high-quality economic growth. Second, the two-pronged policy effect of environmental protection interview and central environmental protection inspection is more significant, and the promotion effect on high-quality economic growth is higher than that of the two policies alone. Third, the dual policy action significantly promotes high-quality economic growth of state-owned companies and non-state-owned companies, but the economic growth of non-state-owned enterprises are more sensitive to the central environmental protection inspection, and the policy effects show a heterogeneous pattern in the east, central, and west regions. Therefore, the effective integration of environmental protection interview and central environmental protection inspection should be accelerated so that environmental pollution control and economic growth can be carried out together.
Lavender Discrimination in Parkinson’s Disease
Authors: Bliwise Donald L. , Trotti Lynn Marie 
Published: April 2022

Abstract
The scent of lavender has been purported to promote sleep in patients with neurodegenerative disease, but an obvious paradox is how, given the widely recognized deficits in olfaction observed in such patients, such an effect could occur. In this study we examined the ability of Parkinson’s Disease patients to discriminate lavender from rose in a forced-choice discrimination task. Results indicated that most Parkinson’s patients could not discriminate lavender above chance, although about a third were able to do so. This preserved ability was unrelated to disease severity or years with diagnosis. It was unrelated to age- and sex-adjusted performance on a standardized test of olfaction (University of Pennsylvania Smell Identification Test). These results were compatible with lavender’s potential impact via trigeminal afferents and leave open the possibility that lavender could indeed impact sleep in some patients with neurodegenerative disease.
Water, hygiene and sanitation practices are associated with stunting among children of aged 24-59 months in Lemo district, South Ethiopia, in 2021
Authors: Woldesenbet Biruk , Tolcha Alemu , Tsegaye Berhan 
Published: April 2022

Abstract
Background
Stunting among children from 24 months to 59 months is a major public health challenge in developing countries like Ethiopia. It has been linked with poor water quality, lack of environmental sanitation, and personal hygiene (WASH) practices. However, complete understandings of risk factors (WASH) which contribute for stunting were not explored at the study area.
Objective
This stud aimed to assess the prevalence and factor associated with stunting among children aged 24–59 months in Lemo district, South Ethiopia, in 2021.
Methods
A community based cross-sectional study was conducted from January 1–30/2011. Data were collected from 415 randomly selected child and mother /caregiver pairs/. A structured and interviewer-administered questionnaire and direct observations of anthropometric status generated WHO Anthropometric were used as means of data collection. Logistic regression analysis was conducted. Variables with p-value < 0.25 in the binary logistic regression model were fitted into multivariable logistic regression analysis to identify factors associated with stunting. Variables with AOR and 95% CI and P-value < 0.05 was computed and reported as final risk factors of stunting in the study setting.
Results
From the total of 422 children, only 415 children were included in the final analysis of this study making a response rate of 98.3%. The prevalence of stunting in the study area is 33.5% (95%CI, 30.4% -36.6%) in this study. Children whose age was from 48–59 months (AOR = 2.8, 95%CI, 2.1, 12.1), children whose age 36–47 months age (AOR = 1.6, 95%CI, 1.1, 7.1), children of uneducated women (AOR = 1.8, 95%CI, 1.5, 4.2), children who live in unimproved toilets (AOR = 1.7, 95%CI, 1.2,2.6), children whose feces was disposed unsafely (AOR = 2.8, 95%CI, 1.57, 5.31), children whose mothers did not wash their during feeding their children (AOR = 6.2, 95%CI, 6.2 (2.0, 19.1) were factors associated with stunting among children of 24 month to 59 months.
Conclusion
Stunting is still high in the study area. Policy makers, program managers and community health works should enhance environmental sanitation, awareness creation about personal hygiene and improved toilet construction and utilization. Furthermore, the local government should work to improve socio-economic status of poor household through inter sectorial collaboration.
LIGHT mediates inflammation in psoriasis by up-regulating cellular proliferation and cytokines production of keratinocytes
Authors: Cao Ting , Ye Cheng-bin , Shi Yu , Zou Ying 
Published: April 2022

Abstract
Background
The pathogenesis of psoriasis is associated with perturbations of immune system. In our previous studies, HVEM served as a LIGHT (homologous to lymphotoxins, inducible, and competes with HSV glycol- protein D), which is also known as receptors for tumor necrosis factor superfamily member 14. HVEM and LTBR were increased in psoriasis compared with health control, revealing a potential correlation in the pathogenesis of psoriasis.
Methods
The objective of this study was to examine LIGHT’s effect on keratinocytes proliferation and its therapeutic potential for psoriasis. We added LIGHT protein, anti-HVEM, anti-LTβR, HVEM interference, LTβR interference, NF-κB inhibitor and JNK/AP-1 inhibitor separately or simultaneously in HaCat cells medium in vitro. The expression of NF-κB was stained by immunofluorescence and the expression of inflammatory products was measured with Western blot and ELISA. HaCat cells viability was examined by CCK-8 kit. Flow cytometry was used to detected the expression of HVEM and LTβR on cells and immunohistochemistry in tissues.
Results
We found that NF-κB transferred from cytoplasm into nuclear after HaCat cells stimulated by LIGHT protein. The expression of p-c-Jun, IL-6, IL-8, PGI2 and PTGS2 was increased when adding LIGHT protein, while decreased after blockading LIGHT’s receptors or inhibiting NF-κB and JNK/AP-1. HaCat cells viability was consistent with the expression of pro-inflammatory factors. The expression of LIGHT and HVEM was increased in lesions of patients with psoriasis.
Conclusions
These results suggest that JNK/AP-1-HVEM-LIGHT pathway improved the viability and the expression of IL-6, IL-8, PGI2 and PTGS2 in human keratinocytes, revealing the JNK/AP-1-HVEM-LIGHT pathway can be a potential target for the treatment of psoriasis.
Synchronous dynamics of spectral greening trends and regional climate variability across Europe
Authors: Kempf Michael 
Published: April 2022

Abstract
Europe witnessed a strong increase in climate variability and extremes over the past decades that caused degradation of ecological and societal resilience. Cascading feedbacks like the 2003 and 2010 heat waves were considered environmental response to anthropogenically reinforced climate anomalies. Land-use intensification, landcover change, and forest degradation further increased the pressure on the ecosystem’s functionalities. Conversely, recent satellite observations emphasized positive vegetation and landcover reflectance trends as a response to rising atmospheric CO₂ input and global warming, particularly in the northern latitudes. However, these global trends obfuscate the intensified regional divergence of climate variability and extremes and risk underestimating future climate induced feedbacks. Consequently, long-term climate trends and variability must be analysed together with annual and interannual anomalies to understand regional feedback mechanisms and surface cover changes. This article presents long-term NDVI (Normalized Difference Vegetation Index) monthly time series analyses compared to multicomponent environmental background variability to highlight European-scale greening trends over the period 2001–2020. Significant warming and persistent hot droughts affect regional vegetation trends in central Europe compared to prolonged phenological phases and reduced snow-cover in north-eastern Europe.
Wireless Theranostic Smart Contact Lens for Monitoring and Control of Intraocular Pressure in Glaucoma
Authors: Hahn Sei Kwang , Kim Taeyeon , Mok Jee Won , Hong Sang Hoon , Jeong Sang Hoon , Choi Hyeon Sik , Shin Sangbaie , Joo Choun-Ki 
Published: April 2022

Abstract
Glaucoma is one of the most menacing irreversible ocular diseases that can cause vision loss in some serious cases. Although Triggerfish has been commercialized for monitoring intraocular pressure (IOP) in glaucoma, there is no smart contact lens to monitor IOP and take appropriate drug treatment in response to the IOP levels. Here, we report a precisely integrated theranostic smart contact lens with a sensitive gold hollow nanowire (AuHNW) based IOP sensor, a flexible drug delivery system (DDS), wireless power and communication systems and an application specific integrated circuit (ASIC) chip for both monitoring and control of IOP in glaucoma. The AuHNW based IOP sensor shows high ocular strain sensitivity, chemical stability and biocompatibility. Furthermore, the flexible DDS can be used for on-demand delivery of timolol for IOP control. Taken together, the IOP levels can be successfully monitored and controlled by the theranostic smart contact lens in glaucoma induced rabbits. This theranostic smart contact lens would be harnessed as a futuristic personal healthcare platform for glaucoma and other ocular diseases.
Characterization of the bacterial microbiome of Amblyomma scalpturatum and Amblyomma ovale collected from Tapirus terrestris “Tapir” and Amblyomma sabanerae collected from Chelonoidis denticulate “Motelo”, Madre de Dios- Peru
Authors: Rojas-Jaimes Jesús , Lindo-Seminario David , Correa-Núñez Germán , Diringer Benoit 
Published: April 2022

Abstract
Ticks are reservoirs and vectors of pathogens of importance in animal and human health. These microorganisms in ticks can play different roles such as endosymbiont, pathogenic, and even unknown. Here we report the bacterial microbiome of adult males Amblyomma scalpturatum and Amblyomma ovale ticks (GARS) collected from Tapirus terrestris, captured in the rural area of San Lorenzo Village and males Amblyomma sabanerae (GART) collected from Chelonoidis denticulate area of Gamitana Farm in Madre de Dios region, Perú. Greater diversity and bacterial richness was evidenced in males ticks (GART; 613.65–2.03) compared to males ticks (GARS; 102.17–0.40) through the Chao and Shanon-Weaver indices. 478 operational taxonomic units were registered corresponding to 220 bacterial genera in GART and 28 bacterial genera in GARS. Francisella was more prevalent in GART (73.2%) and Acinetobacter in GARS (96.8%) in GARS suggesting that they constitute the central microbiome of Amblyomma sabanerae and Amblyomma scalpturatum / Amblyomma ovale respectively.The genus Francisella was prevalent in males of A. sabanerae collected from C. denticulate, and the genus Acinetobacter was prevalent in males of A. scalpturatum / A. ovale collected from T. terrestris, the bacterial richness and diversity being greater in A. sabanerae males. These metagenomic findings are the first reported in A. scalpturatum / A. ovale and A. sabanerae collected from T. terrestris and C. denticulate in the Peruvian Amazon.
Effects of AMF on the growth and cadmium uptake of maize grown on polluted soils of three land-use types with different cadmium contents
Authors: chen jiaxin , Guo Jianfang , Li Zuran , Liang Xinran , You Yihong , He Yongmei , Li Mingrui , Zhan Fangdong 
Published: April 2022

Abstract
Arbuscular mycorrhizal fungi (AMF) exist widely in soils polluted by heavy metals and have significant effects on plant growth and cadmium (Cd) uptake. There are three land-use types (wasteland, farmland and mountain) with different Cd pollution levels in a lead-zinc mining area in Huize County, Yunnan Province, Southwest China. The effects of AMF on the growth, root morphology and exudate content, rhizosphere Cd speciation and Cd uptake by maize were investigated via a root-bag experiment. The results showed that AMF increased the height and biomass of maize grown soils of the three land-use types, resulting in increases in root length, surface area, volume and branch number, and its effects were higher on maize grown on farmland soil than on wasteland and mountain soils. AMF increased the malic acid and succinic acid contents secreted by maize roots in farmland and mountain soils, enhanced the contents of iron and manganese oxidized Cd, and decreased the content of organic bound Cd in the maize rhizosphere. Moreover, AMF increased Cd uptake in shoots by 12.5 and 1.7 times, and improved Cd uptake in roots by 25.7% and 86.6%, in farmland and mountain soils, respectively. Correlation analysis showed that the Cd uptake in shoots was significantly or significantly positively correlated with the root surface area and root volume and with the contents of the tartaric acid, malic acid and succinic acid secreted by the roots. Thus, the increased maize Cd uptake promoted by AMF was closely related to its affecting root morphology and low molecular weight organic acid secretion, and its effects varied among soils of land-use types with different Cd pollution levels.
Lp-minimal solutions of BDSDEs with left continuous and stochastic linear growth coefficients and p in (1;2)
Authors: OWO Jean Marc 
Published: April 2022

Abstract
In this work, we investigate backward doubly stochastic differential equations. We derive via suitable approximation and comparison theorem, existence of minimal solution in L p sense, for any p in (1;2), when the coefficients are left continuous with stochastic linear growth.
Size and Cycle in Dusky Salamanders: a Female Perspective
Authors: Bruce Richard C. 
Published: April 2022

Abstract
The equal fitness paradigm (EFP) is a life-history model in which the currency of fitness is usable energy rather than individuals, and the principal tradeoff is between survival, evaluated as generation time, and productivity, evaluated as growth and reproductive rates. In the current study I examined variation in generation time, age at first reproduction, and productivity in salamanders of the genus Desmognathus within the framework of the EFP. Desmognathus salamanders are restricted to eastern North America, with a center of distribution in the southern Appalachian Mountains. The data sources of the present report are published studies of life histories and demographics of five species of Desmognathus that include the smallest and largest members of the genus. The analysis showed that Desmognathus salamanders have greater ages at first reproduction, lengthier generation times, and lower productivities than are predicted by the scaling functions of the EFP for vertebrates of equivalent sizes. The differences among species in these parameters are correlated with variation in adult body size and the association between body size and habitat utilization in the genus, wherein the largest species are aquatic in mountain streams, and the smallest are terrestrial in mesic forests. Streamside species of intermediate size exploit a broader range of habitats and are more widely distributed than the stream- and forest-dwelling forms. It is likely that the streamside mode of life in Desmognathus represents an adaptation promoting dispersal. Adaptive radiation in the genus is expressed in extreme life-history and body-size diversification mediated through variation in age at first reproduction and generation time.
Neuroevolution Multiclass Diabetic Retinopathy Classification of Eye Fundus Images
Authors: Pérez-Estigarribia Pastor E , Gómez Jordan Ayala , Gardel-Sotomayor Pedro E. , Benítez Veronica E. Castillo , Matto Ingrid Castro , Noguera José Luis Vázquez , García-Torres Miguel , Mello-Román Julio César , Pinto-Roa Diego Pedro , Aquino-Brítez Diego , Gomez Santiago , Facon Jacques 
Published: April 2022

Abstract
Diabetic retinopathy is a complication of a widespread eye disease named diabetes mellitus. Diabetes mellitus, due to the increased glucose levels, may damage the retina’s blood vessels and cause visual complications and eventually blindness. Therefore, early detection and adequate assessment of disease progression are crucial for adequate treatment. The most widely used method for diagnosing diabetic retinopathy is the analysis of retinal fundus images obtained by retinography. Deep Learning-based methods have shown promising results as a diagnostic tool for diabetic retinopathy, achieving, in some cases, performance close to the human inspection of images. However, the performance of these methods relies heavily on fine-tuning the algorithm hyperparameters and big data sets. In this work, we propose training a Deep Learning network with evolutionary algorithms to classify three stages of Diabetic Retinopathy: i) no sign of diabetic retinopathy, ii) Non-proliferative diabetic retinopathy, and iii) proliferative diabetic retinopathy. We propose a neuroevolution methodology for selecting the most efficient Deep Learning model. The results of the neuroevolution methodology were improved by including Simulated Annealing strategies, Population Reinitialization and ensembles. With high accuracy, sensitivity, specificity and kappa index rates, the experiments show that our neuroevolution methodology for selecting the Deep Learning model hyperparameters is a competitive alternative for training deep neural networks to classify three stages of diabetic retinopathy even with a small data set.
The Evolution of Snow Depth over the Southern Tibetan Plateau in Late Spring to Early Summer and Roles of the Air Temperature
Authors: Zhang Chengyang , Zheng Zhihai , Ou Yi , Zhang Tuantuan , Xiao Zhixiang , Lai Sheng , Chen Sirong , He Hui 
Published: April 2022

Abstract
The southern Tibetan Plateau (TP) is the snow cover area during cold season but exhibits faster snow melting in early summer. Using in-situ observations and improved satellite-derived data, the present study indicates that the snow depth (SD) over southern TP exhibits distinction characteristics between late spring (i.e., P1: April 16th–May 15th) and early summer (i.e., P2: May 16th–June 14th). In terms of climate states, the snow melting rate over southern TP in P2 is faster than that in P1. The acceleration of snow melting during P2 is mainly found over high elevation areas caused by the increase of local air temperature. Diagnoses of the thermodynamic equation further demonstrate that the warming over southern TP during the two periods is mainly attributed to the meridional temperature advection and diabatic heating in situ. On interannual time scale, the SD over southern TP is closely related to diabatic heating over the South Asia. During P1, the diabatic cooling from the southern Bay of Bengal eastward to the western South China Sea suppresses convection over Bay of Bengal and southern TP, resulted in an upper-level anomalous cyclone and cold temperature anomalies from the surface to 200hPa over southern TP, favoring the above-normal SD over southern TP. On the other hand, observational results show that SD over the southern TP in P2 is closely related to diabatic cooling over the northern Indochina Peninsula and diabatic heating over the southern China, but the modelling results could not provide further evident, which warrants a further investigation.
Experimental study on capillary performance of sintered powder porous wick for loop heat pipes
Authors: Wei Jinjia , Yang Xiaoping , LIU Jie , WANG Gaoxiang 
Published: April 2022

Abstract
The performance of loop heat pipes (LHP) is determined by porous wick. In this paper, the comprehensive properties of sintered nickel powder porous wicks were systematically studied. Three particle sizes (average diameter 2~20 μm), pore-forming agent content (0%~30%wt) and two preparation methods (loose sintering and cold press sintering) were utilized to prepare 42 samples. The results showed that with the increase of the particle size and pore-forming agent content and the decrease of the preparation pressure, the porosity and average pore size increased, and capillary performance was enhanced due to the improvement in the connectivity of internal pores. However, the mechanical strength of the wick decreased. To guarantee the working life of LHP, the pore-forming agent content was suggested to be < 10% for loose sintering and < 20% for cold press sintering. An improved model for the capillary performance and permeability of wicks was established. The predicted results agreed well with the experimental ones. Moreover, the Kozeny-Carman constants under various factors were obtained, which were much smaller than the recommended values in published literatures.