bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value co-creation and data-driven orientation: reflections on restaurant management practices during COVID-19 in Italy
Authors: Polese Francesco , Botti Antonio , Monda Antonella 
Published: March 2022

Purpose
Covid-19 pandemic impacted the tourism industry worldwide. Especially in catering, where restaurateurs have had to reinvent their business models, information and communication technologies (ICTs) play a fundamental role in supporting these changes, transforming barriers into opportunities. The purpose of this study is to investigate how restaurateurs’ perception of ICTs has changed before and during Covid-19 and to detect whether ICTs can be considered a tool to foster antifragility, resilience and value co-creation as ideal outcomes.

Design/methodology/approach
This study presents a longitudinal study on the use of ICT platforms by Italian restaurant managers. The case study analyzed is TheFork. Data collection took place in two different rounds: before Covid-19 (year 2017) and during Covid-19 (year 2020).

Findings
The findings of this study reveal how new rules imposed by the Government changed restaurant managers’ attitudes towards technology. In 2017, restaurateurs showed reticence towards technology, not used in a strategic way; today, everyone uses ICT to improve business.

Originality/value
The study shows that ICT platforms enable antifragility, resilience and value co-creation, creating a service ecosystem supporting restaurant management.
Dissecting the “do good and do well” phenomenon: The case of the UK's market for social investment
Authors: Daggers Jess 
Published: March 2022

AbstractThe developing discourse around social investment and impact investing makes strong claims regarding the possibility of both furthering one's own interests while simultaneously acting for the benefit of others—“doing good and doing well”. Such claims are central to UK‐ and US‐centric attempts to reform capitalism in the face of multiple global crises. This article uses Foucault's writing on (neo)liberal governmentality to analyze a particular manifestation of the logic of “doing good and doing well”: the attempt to build a market for social investment in the UK between 2010 and 2016, a project closely related to the development of the broader impact investment movement. Building on a close reading of Foucault's writing on the role of self‐interest, it is argued that two incompatible versions of social investment are present within the development of the market: one (the “innovative version”) that assumes purpose and profit are fully compatible, and one (the “principled version”) that assumes it is important to maintain a boundary between them. The relevance of these findings and the approach used is discussed in relation to the social studies of market, and ongoing efforts to develop a critique of “doing good and doing well”.
Assessing agreement among crime scene measurement methods
Authors: Lawas Maria , Williams Susan Y. , Jameson Steven , Gonzalez Anthony R. , Ernst Paula , Donfack Joseph 
Published: March 2022

AbstractA critical concern with crime scene documentation is the accuracy with which a crime scene can be reconstructed. Here, we discuss the accuracy of eight documentation methods as a function of measurement distance between reference ground targets in an outdoor scene. The relative accuracy of each documentation method was assessed with respect to a widely accepted and well‐established standard method for land surveying, Total Station, from which measurements served as “ground truth” or reference data. For the majority of methods, the actual relative difference between measurements when compared to Total Station was small (less than a quarter of an inch). Measurements from FARO LiDAR agreed the most with to those of Total Station, while drone without the use of ground control points (GCPs) agreed the least. GCPs or a reference scale were also found to be important in mitigating increasing imprecision with increasing distance when measuring between two targets ~9–85 ft apart via drone and orthomosaic methods. Additionally, there were no statistical differences in the use of 2D (horizontal) or 3D (slope) measurement configurations for the Total Station. Overall, linear regression of difference plots did not reveal meaningful correlation between increasing distance measured and the error of a method when compared to Total Station. As more measurement methods become available, and the need for training and validating new tools become a necessity, these results point to the importance of establishing a ground truth or known distance range on which crime scene measurement methods can be validated.
C3c deposition predicts worse renal outcomes in patients with biopsy‐proven diabetic kidney disease in type 2 diabetes mellitus
Authors: Li Meng‐Rui , Sun Zi‐Jun , Chang Dong‐Yuan , Yu Xiao‐Juan , Wang Su‐Xia , Chen Min , Zhao Ming‐Hui 
Published: March 2022

AbstractBackgroundAlthough extensive efforts have been paid to identify reliable predictors for renal outcomes of diabetic kidney disease (DKD) patients in type 2 diabetes mellitus (T2DM), there are still only a limited number of predictive factors for DKD progression. Increasing evidence reported the role of the overactivated complement system in the pathogenesis of DKD. Whether renal complement depositions are associated with renal outcomes of DKD in T2DM is of interest.MethodsA total of 213 biopsy‐proven DKD patients with T2DM were retrospectively recruited. Clinical and pathological data of the patients were analyzed. Kaplan‐Meier analysis and Cox regression analysis were performed to explore predictors of end‐stage renal disease (ESRD).ResultsDuring a median follow‐up of 23.0 (12.0, 39.0) months, 100/213 (46.9%) patients progressed to ESRD. C3c and C1q deposition were observed in 133/213 (62.4%) and 45/213 (21.1%) patients, respectively. Kaplan‐Meier analysis revealed patients with C3c or C1q deposition had significantly worse renal outcomes compared with those without C3c or C1q deposition (p = .001 and p < .001, respectively). Univariate and multivariate Cox regression analysis demonstrated proteinuria (per 1 g/24 h increase, hazard ratio [HR] 1.134, 95% confidence interval [CI] [1.079, 1.191], p < .001), interstitial fibrosis and tubular atrophy score (score 2 and 3 vs. 0 and 1, HR 3.925, 95% CI [1.855, 8.304], p < .001), and C3c deposition (per 1+ increase, HR 1.299, 95% CI [1.073, 1.573], p = .007) were independent predictors for ESRD in DKD patients with T2DM.ConclusionsC3c deposition in the kidney was associated with worse renal outcomes and was an independent predictor for ESRD in DKD patients with T2DM.
Wild meat hunting levels and trade in a West African protected area in Togo
Authors: Sonhaye‐Ouyé Abré , Hounmavo Amétépé , Assou Delagnon , Afi Konko Florence , Segniagbeto Gabriel H. , Ketoh Guillaume K. , Funk Stephan M. , Dendi Daniele , Luiselli Luca , Fa Julia E. 
Published: March 2022

AbstractWe assessed numbers and biomass of species hunted and sold for wild meat in 12 park‐adjacent settlements in the Fazao Malfakassa National Park (FMNP), Togo. From hunter interviews and market carcass counts, 33 species, 28 from hunter interviews and 26 from market surveys were taken, respectively. A total of 2605 animals were recorded in the study, 18 species during the wet season (740 animals) and 26 species in the dry season (1865 animals). In markets, 754 carcasses of 19 species were traded during the wet season, and 1896 carcasses of 24 species in the dry season. Most species were relatively small‐bodied mammals (62% of total numbers of animals reported), the rest large ungulates. Species were generally of minor conservation concern (LC or NT) with only three EN and NE. From the gathered field data, we estimated that an average of 9095 ± 5613 animals per study village were hunted per year, amounting to a biomass of 198,334 ± 191,930 kg. Despite efforts to protect the wildlife within the FMNP, reported level of hunting, particularly of large ungulates within the park, the reported level of hunting is likely to have severe consequences on the long‐term viability of this important protected area.
Impacts of the COVID‐19 pandemic on livelihoods and wild meat use in communities surrounding the Dja Faunal Reserve, South‐East Cameroon
Authors: Kamogne Tagne Cédric Thibaut , Brittain Stephanie , Booker Francesca , Challender Dan , Maddison Neil , Milner‐Gulland Eleanor Jane , Mouamfon Mama , Roe Dilys , Coad Lauren 
Published: March 2022

AbstractThe COVID‐19 outbreak has had considerable negative impacts on the livelihoods and living conditions of communities around the world. Although the source of COVID‐19 is still unknown, a widely spread hypothesis is that the virus could be of animal origin. Wild meat is used by rural communities as a source of income and food, and it has been hypothesised that the pandemic might alter their perceptions and use of wild meat. McNamara et al. (2020) developed a causal model hypothesising how the impacts of the pandemic could lead to a change in local incentives for wild meat hunting in sub‐Saharan African countries. From February 27 to March 19, 2021, we carried out a survey around the Dja Faunal Reserve, Southeast Cameroon, to test McNamara et al.’s model in practice, using semi‐structured questionnaires to investigate the impacts of the COVID‐19 outbreak on wild meat hunting and consumption. Our results generally agree with the causal pathways suggested by McNamara et al. However, our study highlights additional impact pathways not identified in the model. We provide revisions to McNamara's model to incorporate these pathways and inform strategies to mitigate the impacts of the pandemic.
Road traffic fatalities in rural and remote Australia from 2006 to 2017: The need for targeted action
Authors: Mason Hannah M. , Leggat Peter A. , Voaklander Don , Franklin Richard C. 
Published: March 2022

AbstractObjectiveTo explore rural motor vehicle collision (MVC) fatalities by trends over time, mode of transport, age, state, sex, and Aboriginal and Torres Strait Islander status.DesignA retrospective total population‐based time series was conducted using the Australian Bureau of Statistics (ABS) death registration data.SettingAll statistical local area (SLA) within Australia from 2006 to 2017.ParticipantsAustralian residents whose deaths were registered with the ABS between 01 January 2006 and 31 December 2017 where the underlying cause of death was related to unintentional transport accidents.Main outcome measuresFatality rates were determined using population data collected from the 2006, 2011 and 2016 census. Trends over time by rurality were analysed by financial year. Rates of transport deaths by vehicle type were determined by rurality. Risk ratios were calculated to compare demographic groups based on sex, Aboriginal and Torres Strait Islander status and age. A 3‐year scorecard was organised by state and rurality using 99.7% confidence intervals.ResultsMotor vehicle collision fatalities increase with increasing remoteness. Females, children from 0 to 14 years, pedestrians, and Aboriginal and Torres Strait Islander peoples are at a significantly higher risk of fatal MVCs than their respective metropolitan counterparts. The 3‐year scorecard indicates that road fatality rates in the NT, WA, and all rural and remote areas required immediate attention and targeted action.ConclusionsThere is a need for investment in MVC fatality prevention in rural Australia from inner regional to remote areas in order to meet the road safety targets established by the National Road Safety Strategy.
Postoperative outcomes in surgical patients with obstructive sleep apnoea diagnosed by sleep studies: a meta‐analysis and trial sequential analysis
Authors: Pivetta B. , Sun Y. , Nagappa M. , Chan M. , Englesakis M. , Chung F. 
Published: March 2022

SummaryIdentifying surgical patients with obstructive sleep apnoea may assist with anaesthetic management to minimise postoperative complications. Using trial sequential analysis, we evaluated the impact of obstructive sleep apnoea diagnosed by polysomnography or home sleep apnoea testing on postoperative outcomes in surgical patients. Multiple databases were systematically searched. Outcomes included: total postoperative complications, systemic complications (cardiovascular, respiratory, neurological, renal, infectious) and specific complications (atrial fibrillation, myocardial infarction, combined hospital and intensive care unit re‐admission, mortality). The pooled odds ratios of postoperative complications were evaluated by the Mantel–Haenszel method random‐effects model. Meta‐analysis and meta‐regression were conducted, and the GRADE approach was used to evaluate the certainty of evidence. Twenty prospective cohort studies with 3756 patients (2127 obstructive sleep apnoea and 1629 non‐obstructive sleep apnoea) were included (9 in non‐cardiac surgery and 11 in cardiac surgery). Postoperative complications were almost two‐fold higher with obstructive sleep apnoea, OR (95%CI) 1.92 (1.52–2.42), p < 0.001; certainty of evidence, moderate. Obstructive sleep apnoea was associated with a 1.5 times increased risk of postoperative cardiovascular complications, OR (95%CI) 1.56 (1.20–2.02), p = 0.001; certainty of evidence, moderate; an almost two‐fold increase in respiratory complications, OR (95%CI) 1.91 (1.39–2.62), p < 0.001; certainty of evidence, moderate; and hospital and ICU re‐admission, OR (95%CI) 2.25 (1.21–4.19), p = 0.01; certainty of evidence, low. Trial sequential analysis showed adequate information size for postoperative complications. Baseline confounding factors were adjusted by meta‐regression, and the sub‐group analysis did not materially change our results. This increased risk occurred especially in patients in whom obstructive sleep apnoea had been newly diagnosed, emphasising the importance of pre‐operative screening.
Two‐year outcomes of tirabrutinib monotherapy in Waldenström’s macroglobulinemia
Authors: Sekiguchi Naohiro , Rai Shinya , Munakata Wataru , Suzuki Kenshi , Handa Hiroshi , Shibayama Hirohiko , Endo Tomoyuki , Terui Yasuhito , Iwaki Noriko , Fukuhara Noriko , Tatetsu Hiro , Iida Shinsuke , Ishikawa Takayuki , Iguchi Daisuke , Izutsu Koji 
Published: March 2022

AbstractThe phase II study of tirabrutinib monotherapy at a daily dose of 480 mg under fasting conditions for treatment‐naïve and relapsed/refractory Waldenström's macroglobulinemia (ONO‐4059‐05 study) demonstrated a promising efficacy and tolerable safety profile. We conducted an unplanned analysis with a median follow‐up of 24.8 months to update the efficacy and safety results and to report patient‐reported quality of life. Of 27 enrolled patients, 22 patients continued receiving the study drug. The major response assessed by an independent review committee was observed in 25 patients (93%), including one and five patients who newly achieved complete response and very good partial response, respectively, after the primary analysis. The progression‐free and overall survival rates at 24 months were 92.6% and 100%, respectively. Serum IgM levels in all patients except one declined and were maintained at low levels, although transient increases occurred after temporal interruption of the study drug. The disease‐related symptoms including recurrent fever and hyperviscosity mostly disappeared. Health‐related quality of life, assessed by cancer‐specific questionnaires, was mostly maintained. Grade 3–4 neutropenia, lymphopenia, and leukopenia were newly recognized in three, two, and one patient, respectively. Grade 3 treatment‐related hypertriglyceridemia was also recognized. Nine patients experienced grade 1–2 bleeding events (33%), one patient experienced grade 2 treatment‐related atrial fibrillation, and one patient experienced grade 1 treatment‐related hypertension. Treatment‐related skin adverse events were observed in 14 patients (52%). Taken together, tirabrutinib has durable efficacy with an acceptable safety profile for treatment‐naïve and refractory/relapsed Waldenström's macroglobulinemia.
Insufficiency of hepatocyte growth factor activator inhibitor‐1 confers lymphatic invasion of tongue carcinoma cells
Authors: Izumi Aya , Yamamoto Koji , Kawaguchi Makiko , Yamashita Fumiki , Fukushima Tsuyoshi , Kiwaki Takumi , Tanaka Hiroyuki , Yamashita Yoshihiro , Kataoka Hiroaki 
Published: March 2022

AbstractHepatocyte growth factor (HGF) activator inhibitor type‐1 (HAI‐1), encoded by the SPINT1 gene, is a transmembrane protease inhibitor that regulates membrane‐anchored serine proteases, particularly matriptase. Here, we explored the role of HAI‐1 in tongue squamous cell carcinoma (TSCC) cells. An immunohistochemical study of HAI‐1 in surgically resected TSCC revealed the cell surface immunoreactivity of HAI‐1 in the main portion of the tumor. The immunoreactivity decreased in the infiltrative front, and this decrease correlated with enhanced lymphatic invasion as judged by podoplanin immunostaining. In vitro homozygous deletion of SPINT1 (HAI‐1KO) in TSCC cell lines (HSC3 and SAS) suppressed the cell growth rate but significantly enhanced invasion in vitro. The loss of HAI‐1 resulted in enhanced pericellular activities of proteases, such as matriptase and urokinase‐type plasminogen activator, which induced activation of HGF/MET signaling in the co‐culture with pro‐HGF‐expressing fibroblasts and plasminogen‐dependent plasmin generation, respectively. The enhanced plasminogen‐dependent plasmin generation was abrogated partly by matriptase silencing. Culture supernatants of HAI‐1KO cells had enhanced potency for converting the proform of vascular endothelial growth factor‐C (VEGF‐C), a lymphangiogenesis factor, into the mature form in a plasminogen‐dependent manner. Furthermore, HGF significantly stimulated VEGF‐C expression in TSCC cells. Orthotopic xenotransplantation into nude mouse tongue revealed enhanced lymphatic invasion of HAI‐1KO TSCC cells compared to control cells. Our results suggest that HAI‐1 insufficiency leads to dysregulated pericellular protease activity, which eventually orchestrates robust activation of protease‐dependent growth factors, such as HGF and VEGF‐C, in a tumor microenvironment to contribute to TSCC progression.
Macular sector‐wise decision tree model for the prediction of parafoveal scotoma not detected by 24‐2 visual field test
Authors: Choe Sooyeon , Ha Ahnul , Jeoung Jin Wook , Park Ki Ho , Kim Young Kook 
Published: March 2022

AbstractBackgroundDevelopment of a macular sector‐wise decision tree model (DTM) for the prediction of parafoveal scotoma.MethodsThis prospective study enrolled 126 patients with early‐stage open‐angle glaucoma (mean deviation ≥−6 decibels) without the signs of parafoveal scotoma on the 24‐2 visual field (VF) test (i.e., any abnormalities at the four innermost points). Based on the central 36 points of the 10‐2 pattern deviation plot, patients were classified as being with or without 10‐2 parafoveal scotoma. For the discrimination of patients from those without 10‐2 parafoveal scotoma, a macular ganglion cell‐inner plexiform layer (mGCIPL) sector‐wise DTM analysis was performed.ResultsAmong 126 eyes without 24‐2 parafoveal scotoma, 10‐2 parafoveal scotoma was detected in 77 (61.1%) eyes. The balanced accuracy of DTM was best in the inferotemporal sector (0.9286; 95% CI, 0.7458–0.9697) and worst in the inferior sector (0.8373; 0.6484–0.9204). DTM revealed that even in the absence of VF abnormalities at the innermost 4 points on the 24‐2 test, (1) 10‐2 parafoveal scotoma should be strongly suspected when the adjacent 24‐2 perifoveal point in the correlated sector is abnormal; (2) if the 24‐2 perifoveal point is normal, and if the probability colour codes of the correlated mGCIPL sector are green, the probability of 10‐2 parafoveal scotoma is very low.ConclusionsIn clinical practice, the evaluation of the 24‐2 perifoveal test points along with the probability colour codes of mGCIPL can be a useful decision‐support tool in determining whether 10‐2 tests are needed for a given patient.
Long non‐coding RNA H19 promotes leukocyte inflammation in ischemic stroke by targeting the miR‐29b/C1QTNF6 axis
Authors: Li Guangwen , Ma Xiaoqing , Zhao Haiping , Fan Junfen , Liu Tianwei , Luo Yumin , Guo Yunliang 
Published: March 2022

AbstractAimsInflammatory processes induced by leukocytes are crucially involved in the pathophysiology of acute ischemic stroke. This study aimed to elucidate the inflammatory mechanism of long non‐coding RNA (lncRNA) H19‐mediated regulation of C1q and tumor necrosis factor 6 (C1QTNF6) by sponging miR‐29b in leukocytes during ischemic stroke.MethodsH19 and miR‐29b expression in leukocytes of patients with ischemic stroke and rats with middle cerebral artery occlusion were measured by real‐time polymerase chain reaction. H19 siRNA and miR‐29b antagomir were used to knock down H19 and miR‐29b, respectively. We performed in vivo and in vitro experiments to determine the impact of H19 and miR‐29b on C1QTNF6 expression in leukocytes after ischemic injury.ResultsH19 and C1QTNF6 upregulation, as well as miR‐29b downregulation, was detected in leukocytes of patients with stroke. Moreover, miR‐29b could bind C1QTNF6 mRNA and repress its expression, while H19 could sponge miR‐29b to maintain C1QTNF6 expression. C1QTNF6 overexpression promoted the release of IL‐1β and TNF‐α in leukocytes, further exacerbated blood‐brain barrier disruption, and aggravated the cerebral ischemic injury.ConclusionsOur findings confirm that H19 promotes leukocyte inflammation by targeting the miR‐29b/C1QTNF6 axis in cerebral ischemic injury.
The birth and development of clinical physiology in Finland
Authors: Laitinen Tomi , Sovijärvi Anssi , Malmberg Pekka , Turjanmaa Väinö , Hartiala Jaakko 
Published: March 2022

AbstractThe specialty of clinical physiology was established in Finland about 20 years later than in Sweden. In the early 1960s, six physicians working mainly in preclinical departments of physiology were certified as specialists in clinical physiology. Many of the first specialists working in hospitals received specialist training in Sweden. The first hospital laboratories of clinical physiology were established in Tampere Central Hospital and Turku University Hospital in 1968. Thereafter, laboratories of clinical physiology were also established in Helsinki University Hospital and in Kuopio University Hospital and later also in most central hospitals. After clinical physiology laboratories were set up in hospitals and the number of specialists increased, the specialty gradually had more impact in clinical work. In the 1999 reform, nuclear medicine, which had previously been a subspecialty, was combined with clinical physiology. Arto Uusitalo was nominated the first professor of clinical physiology in Tampere University in 1984. The first professor in Helsinki University was Anssi Sovijärvi (1994), in Kuopio University Esko Länsimies (1998), and in Turku University Jaakko Hartiala (2003). Today, at four universities professors of clinical physiology and nuclear medicine lead research and medical education in this specialty. The hospital laboratories have modern equipment, which promotes multidisciplinary research with clinicians in fruitful collaboration. The Finnish Society of Clinical Physiology was founded in 1975. Today, it has about 160 members, about half of whom are specialists in the field. On its 40th anniversary, the Society decided to publish the history of clinical physiology in Finland.