bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical therapy in patients with Duchenne muscular dystrophy: dynamics of the course of the disease
Authors: Suslov Vasiliy M. , Lieberman Larisa N. , Suslova Galina A. , Bure Natalia P. , Adulas Elena I. , Rudenko Dmitry I. 
Published: August 2022

BACKGROUND: Duchenne muscular dystrophy is the most severe and common form among childhood muscular dystrophies, characterized by a progressive course. One of the main measures to slow down the rate of progression of the disease is physiotherapy, but now there are no recommendations to identify the optimal motor regimen, which is effective and safe for patients with Duchenne muscular dystrophy.
AIM: The aim of the study was to evaluate the effectiveness of regular dynamic aerobic exercise in patients with Duchenne muscular dystrophy who are capable of independent movement.
MATERIALS AND METHODS: We examined 15 patients with genetically confirmed Duchenne muscular dystrophy aged 4,9 to 9,0 years (mean age 6,9 years) who did not participate in rehabilitation programs with exercise therapy for 6 months prior to inclusion in the study. All patients underwent a course of physical therapy, the duration of the course was 4 months, the course was divided into 2 stages: preparatory stage (individual cardiac functional reserve 5160% with the number of repetitions of each exercise 68 times) and training stage (individual cardiac functional reserve 6170% with the number of repetitions each exercise 1012 times) The duration of the training was 60 minutes. At the baseline and during dynamic observation after 2 and 4 months, the following were evaluated: 6-minute walk test, timed function test (time to stand from supine, running 10 m, time to climb and descent 4 stairs).
RESULTS: Statistically significant positive dynamics was revealed: the average values of the distance of the 6-minute walk at the baseline were 478,2 10,1 m, then 489,5 11,4 m (p 0.05) after 2 months and 502,6 10,7 m (p 0.005) after 4 months. The average values of the time to stand from supine at the baseline was 3,7 0,2 sec., after 2 months 3,5 0,2 sec. (p 0.08), after 4 months 3,5 0,2 sec. (p 0.05). Mean values of time to run 10 m at baseline 4,3 0,1 sec., after 2 months 4,1 0,2 sec. (p 0,05), and after 4 months 4,1 0,1 sec. (p 0.005).
CONCLUSIONS: Thus, the regular performance of aerobic physical therapy exercises without weights in combination with training on an exercise bike can increase endurance and speed in ambulant patients with Duchenne muscular dystrophy.
L’Amas ardent de Yamen Manai ou comment penser la crise politique au miroir de l’écologie
Authors: Zlitni-Fitouri Sonia 
Published: August 2022

Il s’agit de montrer, dans cette étude, comment l’écrivain tunisien Yamen Manai, met en scène dans L’Amas ardent les mécanismes d’une crise environnementale doublée d’une crise politique. Il y pose un double regard à la fois nostalgique sur le temps d’« avant-crise », celui d’une relation harmonieuse entre l’homme et la nature, et inquiet face à un monde en danger. Cette inquiétude écologique semble s’affirmer à travers un réalisme magique et une imagerie donnant l’impression d’un climat de « crise » générale. Ce récit, sous forme de conte, mêle en effet subtilement écologie et satire politique dans la Tunisie moderne. Le Don, un apiculteur vivant auprès de ses abeilles, loin des hommes et de l’agitation du monde, voit un jour ses ruches saccagées et ses abeilles coupées en deux par milliers. En s’interrogeant sur ce redoutable fléau, il part en quête de ce mystère dans une contrée bouleversée par le printemps arabe, en proie aux fanatiques de Dieu. L’écriture de la crise, écartant toute forme de pathos, s’appuie sur une verve ironique rappelant les contes philosophiques de Voltaire et une réflexion sur les questions environnementales qui débouche sur un imaginaire écologique.
Des crises d’identité (post)migratoire en Belgique francophone
Authors: Szczur Przemysław 
Published: August 2022

Le présent article constitue une tentative d’exploiter, à des fins d’analyse du personnage littéraire, la notion de crise d’identité, récemment développée par Nathalie Heinich dans son ouvrage Ce que n’est pas l’identité. Pour ce faire, l’auteur s’appuie sur des exemples tirés de romans de Leïla Houari (Ni langue ni pays) et de Girolamo Santocono (Dinddra), deux auteurs belges contemporains d’origine migrante. Leurs personnages, migrants ou descendants de migrants, vivent des expériences qui s’apparentent à celle conceptualisée par Heinich. L’auteur interroge les raisons de ces crises identitaires (post)migratoires, leur déroulement et leur issue. Il s’avère que l’identité des migrant(e)s et de leurs descendant(e)s, marquée par une instabilité fondamentale, est particulièrement sujette à la crise. Toutefois, si l’identité (post)migratoire peut souvent être qualifiée de « crisique », les crises que traversent les personnages aboutissent habituellement à un dénouement positif.
De la crise à une réconciliation (im)possible dans l’univers houellebecquien
Authors: Wojciechowska Magdalena 
Published: August 2022

L’objectif du présent article est de démontrer que malgré le pessimisme apparent de la narration, témoignant d’une société en crise, les récits de Michel Houellebecq fournissent également des indications précieuses quant à la manière dont ces crises peuvent être surmontées, ce qui les situe parmi les ouvrages littéraires dits « réparateurs ». L’analyse des origines et des enjeux de la crise sociétale ainsi que de la manière dont celle-ci résonne dans l’univers houellebecquien constitue la première partie de l’étude et le point de départ de réflexions sur le rôle de la poétique du désordre dans la réconciliation avec soi-même et avec le monde. Les dispositifs assurant une meilleure gestion des phases critiques – l’empathie, l’ironie, l’humour – sont bien présents chez l’écrivain. L’examen d’extraits de deux de ses romans, La Possibilité d’une île (2005) et Sérotonine (2019), permettra de mieux comprendre comment y sont exploitées les possibilités qu’offrent ces outils.
Crystal chemistry features of the Sr-rich aqualite-like mineral from the Konder alkaline complex
Authors: . Rastsvetaeva R. 
Published: August 2022

A hydrated Sr-rich member of the eudialyte-group mineral from Konder (Southern Yakutia) alkaline complex has been investigated by the methods of electron probe microanalysis and X-ray diffraction. The crystal structure was refined to R = 3.9 % in the anisotropic approximation of atomic displacements using 2188 independent reflections with F > 3(F). The unit-cell parameters are: a = 14.1039(2), c = 31.0743(4) Å, V = 5353.1 Å3; the space group R3. The chemical composition of the studied mineral (Z = 3):
Na3.87K0.06Sr1.01Ba0.16Ca4.65REE0.47Y0.3Fe0.38Mn1.27Zr2.92Hf0.3Ti0.09Nb0.12Mg0.07Si25.83O72Cl0.17.
The crystal chemistry features of the mineral and its place among hydrated eudialytes are discussed.
Young health in the context of culture crisis
Authors: Leshchenko Ya. A. , Lisovtsov A. A. 
Published: August 2022

Purpose: assess changes in the health state of teenage-youth due to the transformation of the sociocultural environment (on the example of the Irkutsk region).Materials and methods. The observation contingent is the population of adolescence (15–19 years old). The subject of the study is the characteristics of the incidence and mortality of the contingent underline in the process of changes in the sociocultural medium. Data on mortality rates were obtained on sites of Federal State Statistics Service and of the Center for Demographic Research of the New Economic School, the trend analysis was carried out by a linear regression analysis using the SPSS program (IBM).Results. In the first half of the post-Soviet period (from 1991 to 2005–2009), in the Irkutsk region, in the contingent of adolescence, there was a rapid increase in the prevalence of some socially determined diseases and states (addiction, sexually transmitted diseases), as well as mortality rates. In the second half of the period (from 2006–2010 to 2020), there was a decrease in morbidity and mortality, however, with all positive shifts, even the relative well-being in these areas was not achieved. In 2019, the mortality rates of young men in connection with suicides in the region exceeded the corresponding figures of Poland 2,5 times, Sweden – 8,2 times; Mortality rates from violent causes (murders) exceeded the corresponding figures of Poland 6,4 times, Sweden – 2,0 times. High levels of socially determined morbidity, adolescence mortality in the post-Soviet period are a consequence of adverse changes in the sociocultural environment.Conclusion. Negative phenomena in the mentally-psychological and somatic health of young people are developing in a state of culture, characterized as “sociocultural destruction”. The latter is due to the processes of marginalization of the population, miscalculations in the areas of state ideology and cultural policies, the destruction and substitution of value orientations, the degradation of morality. The most important task facing the authorities and society is to overcome the factors leading to socio-cultural destruction, strengthening the integrity of the consolidating ethnic group of the cultural system.
PENGARUH UPAH DAN BEBAN KERJA TERHADAP LOYALITAS KERJA PARA PEKERJA BURUH TANI DUSUN PANDEAN, DESA BANJARSARI WETAN, KECAMATAN DAGANGAN, KABUPATEN MADIUN
Authors: Aziz Rivai  , Dwi Setya Nugrahini  
Published: August 2022

Abstract: Pandean Hamlet, Banjarsari Wetan Village, Dagangan District, Madiun Regency, the average community works as farm laborers. The large number of farm laborers is because the location is part of the outskirts of the city and is influenced by the education level of some people, which is arguably not too high and close to agricultural land. Based on observations and interviews, farm workers in Dusun Pandean receive a certain amount of wages and long hours. However, the fact is that farm laborers are still loyal to their employers and this contradicts the existing theory. The purpose of this study was to determine the effect of wages and workload both variable and concurrently on work loyalty. This type of research uses quantitative associative methods, with a population of 49 agricultural laborers in Pandean Hamlet. The sampling technique used is total sampling, meaning that the entire population is taken as a sample. Processing and analyzing data with the help of SPSS 23 software. The data analysis technique used was multiple linear regression. The results showed that partially the wage variable obtained a value of (sig) 0.013 <0.05 and the workload variable of (sig) 0.523 > 0.05. Simultaneously obtained a value (sig) of 0.024 <0.05. The R2 value obtained is 14.9%, the remaining 85.1% is influenced by other factors not examined by the researcher.Dusun Pandean, Desa Banjarsari Wetan, Kecamatan Dagangan, Kabupaten Madiun, rata-rata masyarakatnya bekerja sebagai buruh tani. Banyaknya pekerja buruh tani ini karena tempat termasuk bagian pinggiran kota dan dipengaruhi tingkat pendidikan sebagian orang yang bisa dibilang tidak terlalu tinggi serta dekat dengan lahan pertanian. Berdasarkan observasi dan wawancara buruh tani yang terdapat di Dusun Pandean menerima upah dengan besaran tertentu dan jam waktu panjang. Namun, faktanya para pekerja buruh tani masih setia pada pemberi kerja yang mereka tempati dan ini bertentangan dengan teori yang ada. Tujuan dalam penelitian ini untuk mengetahui pengaruh upah dan beban kerja baik secara pervariabel maupun bersamaan terhadap loyalitas kerja. Jenis penelitian ini menggunakan metode kuantitatif asosiatif, dengan populasi para pekerja buruh tani Dusun Pandean sebesar 49 orang. Teknik sampling yang digunakan yaitu sampling total, artinya seluruh populasi diambil untuk dijadikan sampel. Pengolahan dan analisis data dengan bantuan software SPSS 23. Teknik analisis data yang digunakan adalah regresi linier berganda. Hasil menunjukkan secara parsial variabel upah diperolah nilai sebesar (sig) 0,013 < 0,05 dan variabel beban kerja sebesar (sig) 0,523 > 0,05. Secara simultan diperoleh nilai (sig) sebesar 0,024 < 0,05. Nilai R2 diperoleh sebesar 14,9% sisannya 85,1% dipengaruhi oleh faktor lain yang tidak diteliti oleh peneliti.
Cardiovascular risk management: the success of target level achievement in high- and very high-risk patients in Hungary
Authors: Jancsó Zoltán , Csenteri Orsolya , Szőllősi Gergő Jószef , Andréka Péter , Vajer Peter 
Published: August 2022

Abstract
Background
The management of risk factors in patients with high cardiovascular risk and its effectiveness is of paramount importance. Over the last decade, several studies have examined the achievement of cardiovascular risk factors' target levels in Europe. In the present Hungarian study, we assessed the cardiovascular risk level of participants in a population aged 40–65 years and the success of achieving risk factors' target levels in high- and very high-risk individuals. We compared these results with those of two similar European studies.
Methods
Our survey is a cross-sectional study involving a total of 37,778 patients aged 40–65 years from Hungary in 2019–2020. Cardiovascular risk levels and target values were set according to the 2016 European guideline. Target achievement was examined in terms of body mass index, waist circumference, blood pressure, total-, LDL-, HDL- cholesterol, triglyceride and (in diabetics) HgA1c levels.
Results
For 37,298 people, all the data were available to determine their cardiovascular risk category. Of these, 23.1% had a high and 31.4% a very high cardiovascular risk (men: 27.1% and 39.6%, women: 20.5% and 26.1%). Achievement of the LDL-C target of 1.8 mmol/l was only 8.0% among patients at very high risk, which is significantly below the European average (29%). Blood pressure target level attainment among high-risk patients was better than the European average (63.4% vs. 44.7%), but slightly lower (49.4% vs. 58%) among very high-risk patients. The proportion of people with type 2 diabetes achieving HgA1c below 7% was 57.3% in the high-risk population and 53% in the very high-risk population, in good agreement with the European average success rates (58.5% and 54% respectively). Waist circumference below 88 cm for women and 102 cm for men was achieved by 29.4% of the very high risk group in our survey, below the European average of 41%.
Conclusions
Our results show that the success rate of cardiovascular risk management in Hungary is below the European average in several parameters. Our data also highlight the low effectiveness of obesity management in Hungary. General practice partnerships may be important sites for positive change.
Ferroptosis-related lncRNA NRAV affects the prognosis of hepatocellular carcinoma via miR-375-3P/SLC7A11 axis
Authors: Zong Ke , Lin Caifeng , Luo Kai , Deng Yilei , Wang Hongfei , Hu Jianfei , Chen Shi , Li Renfeng 
Published: August 2022

Abstract

Ferroptosis has important value in cancer treatment. It is significant to explore the new ferroptosis-related lncRNAs(FRLs) prediction model in Hepatocellular carcinoma (HCC) and the potential molecular mechanism of ferroptosis-related lncRNAs. We constructed a prognostic multi-lncRNA signature based on ferroptosis-related differentially expressed lncRNAs in HCC. qRT-PCR was applied to determine the expression of lncRNA in HCC cells. The biological roles of NRAV in vitro and in vivo were determined by performing a series of functional experiments. Further, dual-luciferase reporter and RNA immunoprecipitation (RIP) assays were used to confirm the interaction of NRAV with miR-375-3P. We identified 6 differently expressed lncRNAs associated with the prognosis of HCC. Kaplan-Meier analyses revealed the high-risk lncRNAs signature associated with poor prognosis of HCC. Moreover, the AUC of the lncRNAs signature showed the utility in predicting HCC prognosis. Further functional experiments show that the high expression of NRAV can strengthen the viciousness of HCC. Interestingly, we found that NRAV can enhance iron export and ferroptosis resistance. Further research showed NRAV via competitively binds to miR-375-3P and attenuates the inhibitory effect of miR-375-3P on SLC7A11, affecting the prognosis of patients with HCC. In conclusion, We developed a novel FRLs prognostic model with important predictive value for the prognosis of hepatocellular carcinoma. NRAV plays an important role in ferroptosis induction through the miR-375-3P/SLC7A11 axis.
The oral bioavailability of soil-borne risk elements for small terrestrial mammals: Microtus arvalis (Pallas, 1778) and Apodemus sylvaticus L. and its implication in environmental studies
Authors: Cadkova Zuzana , Vořechovská Lenka , Javorská Denisa , Száková Jiřina , Tlustoš Pavel 
Published: August 2022

Abstract
The aims of this study were: i) to specify real risk elemetnt (RE) uptake by wild terresrrial mammals (A. sylvaticus and M. arvalis), ii) to describe RE distribution in critical organs such as liver and kidney, and iii) to determine potencial differences in RE toxicokinetics with regards to individual species or sex. Three groups of experimental animals were fed diets amended with soil and green biomass of hyperaccumulator Arabidopsis halleri with different RE levels. The contents of As, Cd, and Pb in the liver and kidneys of the animals reflected the element contents in the diet. Higher Cd and Pb accumulation ability was observed in A. sylvaticus compared to M. arvalis tissues, and an opposite pattern was recorded for As. Zn contents in tissues of both species remained unchanged, and total contents of Zn in the exposed animals even tended to decrease compared to the controls. Results of this study indicate a generally similar response of both species to elevated RE contents in the diet, confirming these wild rodents as suitable models for RE biomonitoring in ecosystems. However, our data highlights some distinction in As toxicokinetics in wood mice compared to that of field voles and a significantly higher accumulation of Pb and Cd in females. Therefore, factors of species and sex should not be overlooked if relevant data are to be obtained in environmental studies conducted on small terrestrial rodents.
Landau-Khalatnikov Subcircuit based Equivalent Circuit Model for Hybrid Perovskite Solar Cells
Authors: Pavu Kiran Susan , Jacob Jobymol 
Published: August 2022

Abstract
Hybrid perovskite solar cell technology has a distinct advantage over the conventional solar cell technologies due to its high predicted efficiency and low manufacturing cost. However, its commercialization is hindered by the unpredictability existing in its J-V characteristics leading to ambiguous efficiency estimation. Modeling the hysteresis in the J-V characteristics is a means of curtailing this ambiguity. It is established in literature that hysteresis models can be derived from the non-linear behavior of ferroelectric materials. Perovskite, which forms the light absorbing region of the solar cell is a ferroelectric material. In this paper, an equivalent circuit model for the hybrid perovskite solar cell is proposed in which the reasons for origin of hysteresis is characterized as varying capacitance to model hysteresis. A Landau-Khalatnikov subcircuit which portrays this variation is the principal addition to the conventional model to include hysteresis effect. The model parameters of the subcircuit are estimated from the inherent properties of perovskites. Hence, the proposed equivalent circuit model is completely physics based and it links the material property of perovskite to its equivalent circuit model parameters.
Evaluation of endo-perio lesions according to different specific classifications
Authors: Robo Ilma , Heta Saimir , Haxhiu Eva , Qirjaqi Bianka , Ostreni Vera 
Published: August 2022

Abstract
Introduction: Endo-perio lesions, beyond the clinical examination, are also assessed by means of radiographs. It is important that the radiographs used for diagnosis are accurate periapical radiographs, based on specific criteria. The study is of cross-sectional type with the collection of radiographic data on the appearance of endo-perio lesions in accurate periapical radiographs. The aim of the study is to evaluate the radiographic signs of endo-perio lesions, to enable the radiographic diagnosis of the lesions and then to divide them according to the subdivisions of the classification system of endo-perio lesions.Materials and methods: The study included 104 periapical radiographs of patients presented to a dental clinic, with objective and subjective complaints of the presence of endo-perio lesions. The radiographs were classified according to the accuracy criteria of periapical radiographs, criteria defined by Prichard. Accurate periapical radiographs were used to classify endo, perio, endo-perio lesions. Endo-perio lesions were classified based on the Simon et al classification and the Torabinejad and Trope classification.Results: The distribution of radiographs depending on the presence of endo or perio lesions varies as follows: endo lesions were presented in 32 cases or in 38% of the radiographs; perio lesions were present in 22 cases or in 26% of the radiographs and endo-perio lesions were in 30 cases or in 36% of the radiographs included in the study.According to the classification Simon etal. radiographs were divided: class a 40%, class b 20% class c 7% class d 10% and class e 23%.According to the Tobabinejad and Trope classification, endo-perio lesions were according to classes specifically: class a 60% class b 17% class c 23%.Conclusions: The main violation of the accuracy criteria of radiographs is mostly related to the displacement of the cone in the up-down direction, which is performed in support of the routine protocol in performing periapical radiographs.The values ​​in the study showed results on the frequency of occurrence relatively the same for both endo lesions and periodontal and in cases of occurrence of endo-perio combination. This data confirms the fact that endo-perio lesions have the same possibility of occurrence, both for endo-only lesions and for perio-only lesions. Despite the different types of endo-perio lesion classification, the distribution across the classification classes shows the same values ​​in equal percentages for true combined endo-perio lesions.
Evaluation of Postoperative Bleeding Control Employing Surgicel: An original article
Authors: Amjadi Mohsen , Hemmati-Ghavshough Mahdi , DadashKarimi Hamed , Mohammad-Rahimi Mohsen 
Published: August 2022

Abstract
BackgroundFor rapid control of bleeding as a potential surgical complication, various techniques and equipment have been developed that can be referred to as local hemostatic agents. Research shows that the Surgicel, as one of such agents, has a significant effect on reducing bleeding in most surgeries, however, in our experimental observations on patients undergoing open prostatectomy, not only no significant reduction was seen in the amount of bleeding, but also in some cases, the Surgicel led to infection. Therefore, in this study, the effect of the Surgicel on infection and bleeding in open prostatectomy was investigated.MethosThirty patients undergoing open prostatectomy were randomly divided into two groups. To control bleeding after suturing the bladder neck, the Surgicel was installed in the first group, while it was not installed in the second group. Hemoglobin, hematocrit, PT, PTT, INR, bleeding rate, and postoperative complications were evaluated in all patients.ResultsIn the studied groups, hemoglobin level and hematocrit percentage before surgery and on the first and second days after surgery along with coagulation status were compared in terms of PT, PTT, and INR. There were no significant differences between the studied variables and baseline variables.ConclusionThe present study revealed that the Surgicel in open prostatectomy cannot be effective in controlling bleeding and can lead to infection.