bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of Impella percutaneous left ventricular assist device in the management of cardiogenic shock: A matter of where and when
Authors: Tarantini Giuseppe , Rodinò Giulio 
Published: January 2022

Key Points
Temporary mechanical circulatory support with Impella pLVAD has increasingly been used in the management of cardiogenic shock in recent years, despite conflicting evidence supporting improved clinical outcomes.
This study shows that the use of pLVAD was associated with both an improvement in hemodynamics as well as a decrease in vasopressor and inotropic support, but the need for escalation of MCS to VA‐ECMO was not uncommon and independently associated with a need for higher vasopressor‐inotropic support on admission.
Earlier pLVAD implantation was associated with a trend toward reduction in mortality, but further randomized trials are needed to assess the appropriate use and efficacy of the Impella device in treating patients with CS.
Decoupled double‐loop FOIMC‐PD control architecture for double integral with dead time processes
Authors: Kumar Deepak , Aryan Pulakraj , Raja G. Lloyds 
Published: January 2022

AbstractA novel double‐loop control configuration with two controllers is suggested for double integrating processes with dead‐time. The stabilizing range of the inner‐loop proportional‐derivative (PD) controller is obtained using the Routh stability criteria. From this range, the exact PD settings are obtained by following a graphical approach where the integration of absolute error (IAE) is plotted for different PD settings. The PD settings resulting in the minimum IAE are chosen. In addition to stabilizing the plant, the inner‐loop also rejects the disturbances. A fractional‐order internal model controller (FOIMC) is designed for satisfactory set‐point tracking response in the outer‐loop. The suggested strategy has four adjustable parameters (proportional and derivative time constants, outer closed‐loop adjustment parameter, and fractional‐order of the FOIMC low‐pass filter). Based on extensive simulations, the tuning ranges for the above‐mentioned adjustable parameters are specified. The simulation study is done with the help of benchmark double integrating plant models with large dead‐time. Quantitative performance measures are also computed for comparing the suggested and previously reported schemes. The suggested FOIMC‐PD control architecture yields enhanced control performance than some recently reported techniques.
Segmentectomy for clinical stage I non–small cell lung cancer: National benchmarks for nodal staging and outcomes by operative approach
Authors: Kneuertz Peter J. , Abdel‐Rasoul Mahmoud , D’Souza Desmond M. , Zhao Jing , Merritt Robert E. 
Published: January 2022

BackgroundSegmentectomy is increasingly used for parenchyma sparing anatomical resection for small stage I non–small cell lung cancer (NSCLC). This study characterizes the national outcomes for lymph node assessment and perioperative outcomes of segmentectomy for clinical stage I NSCLC by robotic‐assisted surgery (RATS), video‐assisted thoracoscopic surgery (VATS), and open thoracotomy approach.MethodsA retrospective cohort study was conducted of patients who underwent segmentectomy for clinical stage I NSCLC captured in the national Society of Thoracic Surgeons General Thoracic Surgery Database between years 2012 and 2018. Inverse probability of treatment weighting (IPTW) was used to balance baseline characteristics. Lymph node (LN) staging and 30‐day outcomes were compared by approach.ResultsA total of 3680 patients (VATS 61.9%, RATS 20%, open 18%) underwent segmentectomy. The IPTW adjusted rate of pathologic LN upstaging (pN1/pN2) was 6.2% (RATS 6.3%, VATS 5.6%, open 8.6%; P = .05). On multivariate analysis, there was no differences in pN1/N2 upstaging between RATS (odds ratio [OR], 0.81; 95% confidence interval [CI], 0.44‐1.49) or VATS (OR, 0.96; 95% CI, 0.57‐1.63) with open segmentectomy. The RATS and VATS approach was associated with fewer postoperative events (RATS 31.3%, VATS 28.8%, open 38.3%; P < .001) and shorter length of stay (RATS 4.3 days, VATS 4.4 days, open 5.2 days; P < .001) as compared with thoracotomy. RATS segmentectomy‐specific complications included a higher rate of pneumothorax after chest tube removal and discharge with chest tube. Major complications were lower after RATS and VATS as compared with open segmentectomy (RATS 5.9%, VATS 4.5%, open 7.2%; P = .028).ConclusionsSegmentectomy by VATS and robotic approach resulted in similar high rates of lymph node upstaging as a global marker of the quality of lymph node dissection and were associated with lower overall morbidity and shorter length of stay as compared with open thoracotomy. These national outcomes may serve as benchmarks for future comparative studies.
Integrated Design of Silkworm‐Chrysalis‐Net‐Like Fe3O4/rGO/Mesoporous Carbon Composites as a High‐Performance Anode Material for Lithium‐Ion Batteries
Authors: Yin Yan , Ma Cheng , Cai Wen‐Di , Qiao Wen‐Ming , Ling Li‐Cheng , Wang Ji‐Tong 
Published: January 2022

AbstractIron‐based oxides are ideal candidates for a new generation of lithium‐ion battery (LIB) anode materials owing to their high theoretical capacity and abundance, low cost, and non‐toxicity. However, the shortcomings of nanoparticle agglomerations with low electrical conductivity, volume expansion, and easy powdering during the cycling process hinder their commercialization. Herein, a silkworm‐chrysalis‐net‐like (SCN) Fe3O4/rGO/mesoporous carbon nano‐architecture composite was prepared by combining an in‐situ sol‐gel coating strategy and a one‐step hydrothermal reaction process. The overall microstructure of the electrode material with a unique SCN structure could effectively create a synergistic effect to enhance the electrochemical performance. As a result, the capacity of rGO‐Fe‐C0.5 could reach 916.4 mA h g−1 after 100 cycles at a current density of 0.5 A g−1, and slow capacity attenuation of 0.033% per cycle after 500 cycles at 2 A g−1 was achieved. This work provides new insights into the design of Fe3O4 based composite for application in lithium‐ion batteries.
Theoretical and X‐Ray Evidence of Electrostatic Phosphonium anti and gauche Effects
Authors: Martins Francisco A. , Chagas Poliane , Thomasi Sérgio S. , Oliveira Luiz C. A. , Diniz Renata , Freitas Matheus P. 
Published: January 2022

AbstractSulphur, not phosphorus, is the only known third‐row element capable of experiencing an electrostatic gauche effect with fluorine. Some six‐membered rings containing an endocyclic phosphorus atom and a β‐fluorine substituent that can interconvert to axial (gauche relative to phosphorus) and equatorial positions were then analysed. While phosphines do not establish an electrostatic attraction between fluorine and phosphorus, some oxidised forms exhibit surprising stability for the sterically disfavoured axial orientation. Because the nature of this behaviour was not obvious, since an intramolecular hydrogen bond can appear, a phosphonium derivative was further studied and its axial conformation was found to be highly stable. A preference for the gauche arrangement appears even for the acyclic and sterically hindered (2‐fluoroethyl)triphenylphosphonium cation. On the other hand, (ethane‐1,2‐diyl)bis(phosphonium) cations are exclusively in anti conformation due to an (+/+)‐electrostatic repulsion between the positively charged phosphonium groups.
Comparison of feasibility and results of frailty assessment methods prior to left ventricular assist device implantation
Authors: Roehrich Luise , Sündermann Simon H. , Just Isabell Anna , Kopp Fernandes Laurenz , Stein Julia , Solowjowa Natalia , Mulzer Johanna , Mueller Marcus , Hummel Manfred , Knierim Jan , Potapov Evgenij , Falk Volkmar , Schoenrath Felix 
Published: January 2022

AbstractAimsAssessing frailty and sarcopenia is considered a valuable cornerstone of perioperative risk stratification in advanced heart failure patients. The lack of an international consensus on a diagnostic standard impedes its implementation in the clinical routine. This study aimed to compare the feasibility and prognostic impact of different assessment tools in patients undergoing continuous‐flow left ventricular assist device (cf‐LVAD) implantation.Methods and resultsWe prospectively compared feasibility and prognostic values of six frailty/sarcopenia assessment methods in 94 patients prior to cf‐LVAD implantation: bioelectrical impedance analysis (BIA), computed tomography (CT)‐based measurement of two muscle areas/body surface area [erector spinae muscle (TMESA/BSA) and iliopsoas muscle (TPA/BSA)], physical performance tests [grip strength, 6 min walk test (6MWT)] and Rockwood Clinical Frailty Scale (RCFS). Six‐month mortality and/or prolonged ventilation time >95 h was defined as the primary endpoint. BIA and CT showed full feasibility (100%); physical performance and RCFS was limited due to patients' clinical status (feasibility: 87% grip strength, 62% 6MWT, 88% RCFS). Phase angle derived by BIA showed the best results regarding the prognostic value for 6 month mortality and/or prolonged ventilation time >95 h (odds ratio (OR) 0.66 [95% confidence interval (CI): 0.46–0.92], P = 0.019; area under the curve (AUC) 0.65). It provided incremental value to the clinical risk assessment of EuroSCORE II: C‐index of the combined model was 0.75 [95% CI; 0.651–0.848] compared with C‐index of EuroSCORE II alone, which was 0.73 (95% CI: 0.633–0.835).Six‐month survival was decreased in patients with reduced body cell mass derived by BIA or reduced muscle area in the CT scan compared with patients with normal values: body cell mass 65% (95% CI: 51.8–81.6%) vs. 83% (95% CI: 74.0–93.9%); P = 0.03, TMESA/BSA 65% (95% CI: 51.2–82.2%) vs. 82% (95% CI: 73.2–93.0%); P = 0.032 and TPA/BSA 66% (95% CI: 53.7–81.0%) vs. 85% (95% CI: 75.0–95.8%); P = 0.035.ConclusionsBioelectrical impedance analysis parameters and CT measurements were shown to be suitable to predict 6‐month mortality and/or prolonged ventilation time >95 h in patients with advanced heart failure prior to cf‐LVAD implantation. Phase angle had the best predictive capacity and sarcopenia diagnosed by reduced body cell mass in BIA or muscle area in CT was associated with a decreased 6 month survival.
Synthesis and Evaluation of Novel Planar‐Chiral Monophosphine Ligands Bearing Ferrocene‐Triazole Backbones
Authors: Sakai Suguru , Kanemoto Kazuya , Fukuzawa Shin‐ichi 
Published: January 2022

AbstractWe prepared novel planar chiral monophosphine ligands bearing ferrocene‐triazole backbones. These ligands were produced in a series of steps that included triazole synthesis by diastereoselective azidation and Huisgen cycloaddition of (S)‐Ugi's amine, followed by methylation and phosphine introduction. This method was applicable to the preparation of various analogues due to the wide substrate scope of the Huisgen cycloaddition reaction. These ligands showed good catalytic activity in Suzuki–Miyaura coupling reactions, especially those involving bulky substrates. Furthermore, the optically active versions of these ligands were used in the asymmetric Suzuki–Miyaura coupling reaction to produce the axial chiral binaphthyl compound with moderate enantioselectivity. The ligand developed in this study is the first triazole‐type biaryl‐ monophosphine ligand that can be used in asymmetric reactions, and it is expected to be a new tool for the accessing chiral compounds.
TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation
Authors: Shiode Yuto , Kodama Takahiro , Shigeno Satoshi , Murai Kazuhiro , Tanaka Satoshi , Newberg Justin Y. , Kondo Jumpei , Kobayashi Shogo , Yamada Ryoko , Hikita Hayato , Sakamori Ryotaro , Suemizu Hiroshi , Tatsumi Tomohide , Eguchi Hidetoshi , Jenkins Nancy A. , Copeland Neal G. , Takehara Tetsuo 
Published: January 2022

Background and Aims:
Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.

Approach and Results:
We performed a Sleeping Beauty transposon‐based in vivo insertional mutagenesis screen in liver‐specific Pten‐deficient mice and identified TNF receptor–related factor 3 (Traf3) as the most significantly mutated gene in murine ICCs in a loss‐of‐function manner. Liver‐specific Traf3 deletion caused marked cholangiocyte overgrowth and spontaneous development of ICC in Pten knockout and Kras
G12D mutant mice. Hepatocyte‐specific, but not cholangiocyte‐specific, Traf3‐deficient and Pten‐deficient mice recapitulated these phenotypes. Lineage tracing and single‐cell RNA sequencing suggested that these ICCs were derived from hepatocytes through transdifferentiation. TRAF3 and PTEN inhibition induced a transdifferentiation‐like phenotype of hepatocyte‐lineage cells into proliferative cholangiocytes through NF‐κB‐inducing kinase (NIK) up‐regulation in vitro. Intrahepatic NIK levels were elevated in liver‐specific Traf3‐deficient and Pten‐deficient mice, and NIK inhibition alleviated cholangiocyte overgrowth. In human ICCs, we identified an inverse correlation between TRAF3 and NIK expression, with low TRAF3 or high NIK expression associated with poor prognosis. Finally, we showed that NIK inhibition by a small molecule inhibitor or gene silencing suppressed the growth of multiple human ICC cells in vitro and ICC xenografts in vivo.

Conclusions:
TRAF3 inactivation promotes ICC development through NIK‐mediated hepatocyte transdifferentiation. The oncogenic TRAF3–NIK axis may be a potential therapeutic target for ICC.
Graphene Acid: A Versatile 2D Platform for Catalysis
Authors: Blanco Matías , Agnoli Stefano , Granozzi Gaetano 
Published: January 2022

AbstractGraphene acid (GA) is a novel graphene platform where the carboxylic acid groups are located in the basal plane of the carbon network. The chemical route to develop such a platform has been proposed and the final product displays a series of advantages with respect to the well‐known and much used graphene oxide (GO), i. e. a more uniform functionalization of the graphene basal plane and an enhanced electronic conduction when compared to GO. In this review we discuss the most recent literature data which demonstrate that the excellent GA properties may have an impact on the catalytic activity of both GA itself and the hybrid derivatives obtained using GA as a scaffold. Examples are discussed where GA as carbocatalyst, molecular catalysts heterogenized on GA and particles/GA assemblies are used as catalysts and electrocatalysts, pinpointing the advantages of using GA with respect to other graphenic substrates.
Cervix type detection using a self‐supervision boosted object detection technique
Authors: Bijoy M. B. , Akondi Sai Manoj , Abdul Fathaah S. , Raut Akash , Pournami P. N. , Jayaraj P. B. 
Published: January 2022

AbstractCervical cancer accounts for a large number of fatalities among cancer patients. It is ranked fourth in the total cancer patients and total number of deaths due to cancer. Developing countries account for 70% of the cases and 90% of the fatalities. Contemporary techniques used for screening cervical cancer are PAP smear test and HPV DNA test. Today there are treatments that can successfully prevent cervical cancer if detected at an early stage. Understanding the cervix type is very important for treatment; computational methods can help us classify the cervix type from cervical images. In this study, we propose an ROI proposal network EfficientCenterDet and a self‐supervision boosted training trick that improves the performance of the network with relatively less labeled data. We use 6114 unlabeled images to perform a pretraining task and 1166 labeled images to retrain the ROI proposal network. The proposed model matches the state‐of‐the‐art IOU of FasterRCNN on the ISIC skin lesions dataset while using one‐third of the number of parameters used in FasterRCNN. On MobileODT cervical data, our self‐supervision boosted model achieves 0.632 IOU, a 10% boost over the state‐of‐the‐art FasterRCNN. Introducing an ensembled EfficientNet B4, the cervix type classification stage achieved an accuracy of 87%.
Application of a cationic amylose derivative loaded with single‐walled carbon nanotubes for gene delivery therapy and photothermal therapy of colorectal cancer
Authors: Chen Zechang , Zhuang Junbo , Pang Jiadong , Liu Zehao , Zhang Penghao , Deng Haijun , Zhang Liming , Zhuang Baoxiong 
Published: January 2022

AbstractSingle‐walled carbon nanotubes (SWNTs) are cylindrical graphitic helix molecules that exhibit superb mechanical and physical properties. Many polymers, such as polyethylene glycol and glycated chitosan, have been used to modify SWNTs to enhance the stability and biocompatibility of delivery systems; thus, a novel modification for SWNTs with amylose derivatives containing poly(L‐lysine) dendrons (ADP@SWNT) is developed. Infrared spectra analysis, 1H NMR analysis, circular dichroism spectra analysis and thermogravimetric analysis are used to characterize and confirm complex formation. The aqueous dispersion stability, cytotoxicity, gene transfection efficiency and photothermal effect of the complex are studied in vitro and in vivo. Results suggest that the ADP@SWNT complex is successfully synthesized with good water dispersion stability and pDNA transfection capacity. ADP@SWNT/TNFα inhibits tumor growth and metastasis both in vivo and in vitro, and the anti‐tumor effect is enhanced by NIR irradiation, suggesting its high potential for application in tumor therapy.
Inter‐laboratory comparison of semiquantitative allergen‐specific Immunoglobulin E test: 7 years of experience in Korea
Authors: Lee Hyeyoung , Ryu Ji Hyeong , Choi Ae‐Ran , Kim Yonggoo , Oh Eun‐Jee 
Published: January 2022

AbstractIntroductionMultiple allergen simultaneous test (MAST) is widely used as a screening tool for allergic diseases and has the advantage of providing specific IgE (sIgE) results for various allergens in semiquantitative class. We have continuously conducted external quality assessment (EQA) since 2012 for clinical laboratories performing MAST using AdvanSure allergy screen test (LG CHEM, Korea). This study provides an account of the EQA experience.MethodsSamples were prepared using pooled sera collected from patients with suspected allergic disease and sent to each laboratory twice a year. Each round included 4–6 serum samples with sIgE for 10–20 inhaled or food allergens. The acceptable class value was the most frequently reported MAST class ±1 titer that exceeded 80% of the total laboratory results.ResultsThe average number of participating laboratories was 76 (49–90) and the average response rate was 97.3% during the entire survey period. The acceptable rates were consistently high at 97.7% ± 3.7%. Of the total 537 trials, 18 trials (3.4%) were regarded as nonconsensus results, in which acceptable answers did not exceed 80%. For unacceptable results, the false‐negative rate (1.5% ± 2.8%) was higher than the false‐positive rate (0.8% ± 2.7%) (p < 0.001). MAST class results were correlated with quantitative IgE results by ImmunoCAP (Spearman's correlation coefficient of 0.682 (p < 0.001) and gamma index of 0.777 (p < 0.001).ConclusionAlthough EQA for MAST showed a high level of acceptable answer, some allergen assays require harmonization. Continuous performance of systematic EQA is needed to improve the accuracy of sIgE assays and quality control in clinical laboratories.
Psychotherapists' personality traits and their influence on treatment processes and outcomes: A scoping review
Authors: Fletcher Ashleigh C. , Delgadillo Jaime 
Published: January 2022

AbstractBackgroundPrior research indicates that patients' personality traits are associated with psychotherapy processes and outcomes. However, the potential relevance of therapists' personality traits is less understood.MethodsThis is a scoping review of studies investigating associations between therapists' personality traits with treatment processes and outcomes. Three databases (Scopus, PsycINFO, and Web of Science) were searched, identifying 27 eligible studies synthesized using a narrative review of key findings.ResultsThe influence of therapists' personality traits was studied in relation to therapeutic orientation, interpersonal skills, therapist competence and skill, model fidelity, treatment outcomes, therapeutic alliance, and therapist well‐being. Findings indicate that therapists' personality traits are associated with the choice of therapeutic orientation and with interpersonal skills, but there is mixed evidence about associations with clinical outcomes.ConclusionTherapists' personality traits are associated with therapeutic orientation and interpersonal skills. However, it remains unclear whether therapists' personality traits influence other aspects of therapeutic processes or outcomes.
Calcined sodium silicate as solid base catalyst for alcoholysis of poly(ethylene terephthalate)
Authors: Tang Shixiong , Li Fang , Liu Jidong , Guo Bao , Tian Zenan , Lv Jianhua 
Published: January 2022

AbstractBACKGROUNDChemical recycling of waste poly(ethylene terephthalate) (PET) is an effective way to save energy and protect the environment. In this work, calcined sodium silicate was adopted as a novel solid base catalyst for methanolysis of PET for the first time. The effects of various parameters on the conversion of PET and the yield of dimethyl terephthalate (DMT) in the methanolysis process of PET were investigated.RESULTSThe results showed that the conversion of PET could reach about 100% and the yield of DMT could reach about 95% under the following conditions: calcined sodium silicate, 5 wt%; molar ratio of methanol to PET, 5:1; reaction time, 30 min; reaction temperature, 200 °C. The higher the mass ratio of methanol to PET and the higher the temperature, the higher were the conversion of PET and the yield of DMT. In addition, the catalyst can be reused more than five times and has good catalytic activity.CONCLUSIONSCalcined sodium silicate has the advantages of low cost, simple fabrication method, high catalytic activity and environmental friendliness. The use of this solid base catalyst is a promising strategy for realizing the recycling of waste polyester. © 2022 Society of Chemical Industry (SCI).