bluuebunny/crossref_metadata_2025_split huggingface dataset:
A contabilidade e o nível de controle interno municipal
Authors: Moraes Júnior Valdério Freire de , Abreu Diego Andrade Gomes de , Melo Janaína Ferreira Marques de 
Published: July 2022

Essa pesquisa teve como objetivo verificar o nível do Controle Interno (CI) do setor contábil da Prefeitura Municipal de João Pessoa (PMJP). Para tanto, foi levantado o perfil dos profissionais do Setor Contábil da Prefeitura; observado de que forma as tarefas são utilizadas no setor supracitado; e averiguado o grau do CI do Setor Contábil da referida Prefeitura. No que tange ao questionário utilizado, este foi estruturado, elaborado e validado, sendo composto por 15 variáveis de investigação e respondido por 15 funcionários. Por sua vez, a eficácia de respostas afirmativas (“Sim” ou “Em parte”) foram classificadas dentro de uma escala de 4 intervalos (ótimo, bom, regular e insuficiente). Em relação aos resultados extraídos, apenas 20% das perguntas tiveram 100% de CI, já a média das respostas afirmativas aponta um percentual de 77,61%, cujo parâmetro foi classificado como bom. Portanto, conclui-se que o Setor Contábil da PMJP tem um bom sistema de controle interno, contudo alguns procedimentos necessitam ser corrigidos e melhorados na boa condução da gestão pública.
La enseñanza del Saxofón en los Conservatorios Profesionales de Música de España. Un estudio desde la percepción del docente
Authors: Estévez-García Óscar , Gértrudix-Barrio Felipe , Zagalaz Juan 
Published: July 2022

The teaching-learning process of the saxophone in Spain has enjoyed an exponential and positive change in recent decades, which has been reflected both in the quality of the saxophonists and in the diffusion of the instrument itself. The aim of this study is to explore teachers' opinions about the saxophone and its formal teaching in the Professional Conservatories of Music in Spain, as well as their vision of the future. The methodology used was non-experimental and exploratory, with the survey as the research instrument. The sample chosen was n73 from a population of 220 saxophone teachers, with simple unweighted allocation, with a confidence level of 90% (two sigma) and P=Q, with a maximum possible error of ±6% for the whole sample and using simple random sampling. The variables analyzed were repertoire and technique, teaching-learning process, learning outcomes, material resources and educational policies. The results show: 1) educational policies are a fundamental support for the development of saxophone education in Spain, 2) a diversification of curricula, methods and saxophone repertoire and contents is needed to design a creative access model to the labor market, 3) the teacher is the best prescriber in the regulated teaching of the saxophone
El proceso de enseñanza-aprendizaje del saxofón en España ha disfrutado de un cambio exponencial y positivo en las últimas décadas que se ha visto reflejado tanto en la calidad de los saxofonistas como en la difusión del propio instrumento. El estudio tiene por objetivo conocer la opinión del docente en torno al saxofón y su enseñanza formal en los Conservatorios Profesionales de Música de España, así como su visión de futuro. La metodología utilizada ha sido no experimental de tipo exploratorio, teniendo como instrumento de investigación la encuesta. La muestra elegida ha sido de n73 de una población de 220 docentes de saxofón, con afijación simple no ponderada, con un nivel de confianza del 90% (dos sigmas) y P=Q, con un error máximo posible de ±6% para el conjunto de la muestra y en el supuesto de muestreo aleatorio simple. Las variables que se han analizado han sido: el repertorio y técnica, procesos de enseñanza-aprendizaje, los resultados de aprendizaje, los recursos materiales y las políticas educativas. Los resultados han señalado que: 1) las políticas educativas han constituido un soporte fundamental para el desarrollo de la educación del saxofón en España, 2) se precisa de una diversificación curricular, métodos y repertorio de saxofón y contenidos que permita crear un modelo creativo de apertura al mercado laboral, 3) el docente constituye el mejor prescriptor en la enseñanza reglada del saxofón.
Internet Memes and Representation of Contemporary Puerto Rican Cities: The Case of Bayamón as a NarcoCity
Authors: Cintrón Gutiérrez Luis Javier 
Published: July 2022

The economic and social systems develop tangible cultural manifestations that seek legitimacy and visibility. This paper discusses internet memes as an alternative narration and representations of contemporary Puerto Rican cities. Memes are a new way of communicating and a new cultural product. The case study that will be analyzed in this essay encompasses Bayamon, the second-most populous city in Puerto Rico and is also considered one of the most violent cities in the Archipelago, by users on social media. The methodology for this research paper will include a semiotic analysis of memes related to Bayamón as posted on diverse social media platforms such as Facebook. The theories to be used for this paper include hybrid cultures and the boundaries of modernity.
Los sistemas económicos y sociales desarrollan manifestaciones culturales tangibles que buscan legitimidad y visibilidad. En este artículo se discute sobre los memes de Internet como una narración y representaciones alternativas de las ciudades puertorriqueñas contemporáneas. Los memes son una nueva forma de comunicación y un nuevo producto cultural. El caso de estudio que se analizará en este ensayo se refiere a Bayamón, que es la segunda ciudad más poblada de Puerto Rico y también es considerada como una de las ciudades más violentas del Archipiélago, por los usuarios en las redes sociales. La metodología que se adoptará para este trabajo de investigación incluirá un análisis semiótico de memes relacionados con Bayamón publicados en diversas plataformas de medios sociales como Facebook. Las teorías que se utilizarán para este trabajo incluyen las culturas híbridas y los límites de la modernidad.
Prioritizing Components of a Dyadic Physical Activity Intervention for People With Moderate to Severe Multiple Sclerosis and Their Care Partners: A Modified e-Delphi Study
Authors: Fakolade Afolasade , McKenna Odessa , Kamel Rachel , Freedman Mark S. , Finlayson Marcia , Latimer-Cheung Amy E. , Pilutti Lara A. 
Published: July 2022

ABSTRACTBACKGROUNDPeople with moderate to severe multiple sclerosis (MS) and their family care partners do not engage in sufficient physical activity (PA) for health benefits. Dyadic PA interventions need to be developed to benefit each individual and the dyad. The objective of this study was to engage expert stakeholders in prioritizing and refining key intervention content, delivery methods, and the practical/logistical aspects of a dyadic PA intervention for persons with MS and their care partners.METHODSThirty-two stakeholders (14 clinicians, 11 people with MS, 5 MS care partners, and 2 representatives of organizations that provide support services for people with MS and/or MS care partners) completed 2 rounds of a modified e-Delphi survey. In round 1, participants rated items across 3 domains: key intervention content (n = 8), delivery methods (n = 9), and practical/logistical aspects (n = 4). Participants contributed additional ideas about these domains, which were incorporated into round 2. Items that did not reach consensus in round 1 were forwarded to round 2 for rerating. Data were analyzed using descriptive statistics and content analysis.RESULTSA 24-item list of recommendations was generated, including ensuring that presentation of the intervention content encouraged lifestyle activities in addition to exercise, using videoconferencing rather than teleconferencing as a delivery platform, and stressing the importance of flexibility during the support calls.CONCLUSIONSFeedback will be used to improve the quality of the intervention. The next step in this line of research involves evaluating the refined intervention in a pilot feasibility trial.
Unbiased mosaic variant assessment in sperm: a cohort study to test predictability of transmission
Authors: Breuss Martin W , Yang Xiaoxu , Stanley Valentina , McEvoy-Venneri Jennifer , Xu Xin , Morales Arlene J , Gleeson Joseph G 
Published: July 2022

Background:De novo mutations underlie individually rare but collectively common pediatric congenital disorders. Some of these mutations can also be detected in tissues and from cells in a parent, where their abundance and tissue distribution can be measured. We previously reported that a subset of these mutations is detectable in sperm from the father, predicted to impact the health of offspring.Methods:As a cohort study, in three independent couples undergoing in vitro fertilization, we first identified male gonadal mosaicism through deep whole genome sequencing. We then confirmed variants and assessed their transmission to preimplantation blastocysts (32 total) through targeted ultra-deep genotyping.Results:Across 55 gonadal mosaic variants, 15 were transmitted to blastocysts for a total of 19 transmission events. This represented an overall predictable but slight undertransmission based upon the measured mutational abundance in sperm. We replicated this conclusion in an independent, previously published family-based cohort.Conclusions:Unbiased preimplantation genetic testing for gonadal mosaicism may represent a feasible approach to reduce the transmission of potentially harmful de novo mutations. This—in turn—could help to reduce their impact on miscarriages and pediatric disease.Funding:No external funding was received for this work.
Development of a high‐resolution two‐dimensional detector‐based dose verification system for tumor‐tracking irradiation in the CyberKnife system
Authors: Kawabata Fumitaka , Kamomae Takeshi , Okudaira Kuniyasu , Komori Masataka , Oguchi Hiroshi , Sasaki Motoharu , Mori Masaki , Kawamura Mariko , Abe Shinji , Ishihara Shunichi , Naganawa Shinji 
Published: July 2022

AbstractWe aim to evaluate the basic characteristics of SRS MapCHECK (SRSMC) for CyberKnife (CK) and establish a dose verification system using SRSMC for the tumor‐tracking irradiation for CK. The field size and angular dependence of SRSMC were evaluated for basic characterization. The output factors (OPFs) and absolute doses measured by SRSMC were compared with those measured using microDiamond and microchamber detectors and those calculated by the treatment planning system (TPS). The angular dependence was evaluated by comparing the SRSMC with a microchamber. The tumor‐tracking dose verification system consists of SRSMC and a moving platform. The doses measured using SRSMC were compared with the doses measured using a microchamber and radiochromic film. The OPFs and absolute doses of SRSMC were within ±3.0% error for almost all field sizes, and the angular dependence was within ±2.0% for all incidence angles. The absolute dose errors between SRSMC and TPS tended to increase when the field size was smaller than 10 mm. The absolute doses of the tumor‐tracking irradiation measured using SRSMC and those measured using a microchamber agreed within 1.0%, and the gamma pass rates of SRSMC in comparison with those of the radiochromic film were greater than 95%. The basic characteristics of SRSMC for CK presented acceptable results for clinical use. The results of the tumor‐tracking dose verification system realized using SRSMC were equivalent to those of conventional methods, and this system is expected to contribute toward improving the efficiency of quality control in many facilities.
Large‐Area Low‐Cost Multiscale‐Hierarchical Metasurfaces for Multispectral Compatible Camouflage of Dual‐Band Lasers, Infrared and Microwave
Authors: Feng Xingdong , Pu Mingbo , Zhang Fei , Pan Rui , Wang Si , Gong Jintao , Zhang Renyan , Guo Yinghui , Li Xiong , Ma Xiaoliang , Luo Xiangang 
Published: July 2022

AbstractMultispectral complementary detection technologies have made single‐band camouflage materials ineffective, creating strong demand for multispectral compatible camouflage materials. Here, multiscale‐hierarchical metasurfaces (MHM) compatible with large‐area low‐cost fabrication are proposed for the first time to realize multispectral camouflage of dual‐band lasers, infrared and microwave. The MHM consists of an all‐metallic metasurface array (AMMA) and a microwave absorber. The AMMA hinders dual‐band lasers and thermal infrared detection, while the microwave absorber beneath the AMMA is applied as a defence against microwave detection. As a proof‐of‐concept, a MHM sample with an area of 30 × 30 cm2 and a minimum linewidth of 1.8 µm is fabricated based on nanoimprint lithography. The excellent multispectral camouflage performance is verified in experiments, showing low reflectance (<0.2) in 0.9–1.2 µm and 9–12 µm, low infrared emissivity (<0.2), and high absorption efficiency of over 90% 2.7–26 GHz. Wide‐angle and polarization‐independent characteristics are also demonstrated. This work offers a promising opportunity for the engineering application of metasurfaces in the multispectral camouflage field. Moreover, this methodology can be easily extended to other electromagnetic spectrum, providing significant guidance for the design and fabrication of multispectral devices.
Efficient Radiolabeling of Block Copolymer Micelles through Radiometal Salt Precipitation for Theranostic Applications
Authors: Liu Huanhuan , de Kruijff Robin M. , Laan Adrianus C. , Beekman Freek J. , van den Heuvel Eline , Ramakers Ruud M. , Eelkema Rienk , Denkova Antonia G. 
Published: July 2022

AbstractA variety of polymer micelles are designed for the delivery of chemotherapeutic drugs to tumors. Although the promise of these nanocarriers is very high, in the clinic the effectivity is rather limited. Determining the in vivo fate of the micelles can greatly help to improve this treatment. Here, a simple and fast chelator‐free method for radiolabeling of polymer micelles composed of different block copolymers is presented, which can allow evaluating the behavior of the nanocarriers in vivo using noninvasive nuclear imaging techniques (e.g., single photon computed tomography, SPECT). The radiolabeling method consists of adding the radioisotope ions, i.e., 111In(III), resulting in a high radiolabeling efficiencies up to 90%. The results suggest that the radiolabeling efficiency depends on two important factors: the properties of the hydrophobic block in the block copolymer composing the micelle core, and the speciation of the radiometal salts. The formation of metal hydroxides and their precipitation in the core of the micelles appears to be a key factor for high stability. Moreover, the method can be applied to radiolabel the micelles in the presence of chemotherapeutic drugs. Finally, a SPECT study shows that the radiolabeled samples are stable in vivo without any evident loss of 111In(III).
Phenotypic characterization of seven individuals with Marbach–Schaaf neurodevelopmental syndrome
Authors: Marbach Felix , Lipska‐Ziętkiewicz Beata S. , Knurowska Agata , Michaud Vincent , Margot Henri , Lespinasse James , Tran Mau Them Frédéric , Coubes Christine , Park Joohyun , Grosch Sarah , Roggia Cristiana , Grasshoff Ute , Kalsner Louisa , Denommé‐Pichon Anne‐Sophie , Afenjar Alexandra , Héron Bénédicte , Keren Boris , Caro Pilar , Schaaf Christian P. 
Published: July 2022

AbstractWe present the phenotypes of seven previously unreported patients with Marbach–Schaaf neurodevelopmental syndrome, all carrying the same recurrent heterozygous missense variant c.1003C>T (p.Arg335Trp) in PRKAR1B. Clinical features of this cohort include global developmental delay and reduced sensitivity to pain, as well as behavioral anomalies. Only one of the seven patients reported here was formally diagnosed with autism spectrum disorder (ASD), while ASD‐like features were described in others, overall indicating a lower prevalence of ASD in Marbach–Schaaf neurodevelopmental syndrome than previously assumed. The clinical spectrum of the current cohort is similar to that reported in the initial publication, delineating a complex developmental disorder with behavioral and neurologic features. PRKAR1B encodes the regulatory subunit R1β of the protein kinase A complex (PKA), and is expressed in the adult and embryonal central nervous system in humans. PKA is crucial to a plethora of cellular signaling pathways, and its composition of different regulatory and catalytic subunits is cell‐type specific. We discuss potential molecular disease mechanisms underlying the patients' phenotypes with respect to the different known functions of PKA in neurons, and the phenotypes of existing R1β‐deficient animal models.
Peripartum management of tuberous sclerosis complex complicated by massive angiomyolipomas
Authors: Knapp C. , Ince M. , Zacharzewski A. 
Published: July 2022

SummaryTuberous sclerosis complex is a genetic disease that can affect multiple organs, commonly the renal, central nervous, cardiac and respiratory systems. Here, we present the peripartum management of a woman with a new diagnosis of tuberous sclerosis complex associated with massive renal angiomyolipomas. There was significant risk of catastrophic haemorrhage from the angiomyolipomas during pregnancy. This created a challenging scenario for the anaesthetists, obstetricians, urologists and interventional radiologists involved in their care, necessitating collaborative working, numerous investigations and honest patient‐centred discussions. Evidence for the management of tuberous sclerosis and angiomyolipomas in pregnancy does not appear to have been previously reported. After much consideration, arterial embolisation of the most vascular area of the angiomyolipoma was completed at 28 weeks gestation under remifentanil sedation. An elective caesarean section under combined spinal epidural anaesthesia was completed at 37 + 3 weeks gestation. Central nervous system involvement must always be considered; benign tumours within the brain and spinal cord may contraindicate neuraxial techniques. Early multidisciplinary involvement is essential due to the diverse and complex nature of tuberous sclerosis. Individuals differ in their presentation and disease severity; therefore, they must be assessed on an individual basis with management tailored accordingly.
Biodiesel from high‐acid‐value grease trap waste: process optimization and purification using bio‐based adsorbent
Authors: Jariah Nurhani Fatihah , Roslan Ahmad Muhaimin , Hassan Mohd Ali , Taufiq‐Yap Yun Hin 
Published: July 2022

AbstractMaterial with negative value such as grease trap waste appears to be a cost‐effective feedstock for biodiesel production since it can be collected at little to no charge. Owing to its high lipid content, fatty acid methyl ester can be produced from grease trap waste via a two‐step production process with methanol, using potassium hydroxide as the catalyst. However, there are several process parameters that could affect the yield of the fatty acid methyl ester produced. In this study, the optimum conditions for biodiesel production were 6:1 methanol‐to‐oil molar ratio, 1.5 wt% potassium hydroxide loadings, a 40 °C reaction temperature and a 2 h reaction time, resulting in a fatty acid methyl ester yield of 87%. Further purification using 0.05 g L−1 of biobased adsorbent from woodchip biomass for a 1 h residence time at 25 °C yielded the highest removal of free fatty acid and soap at 98.2 and 67.9%, respectively. This study not only demonstrates the potential of grease trap waste as a bioresource for the production of biodiesel, but also proves an interesting and additional use of bio‐based adsorbent from woodchip biomass as an effective tool in biodiesel purification since the quality of biodiesel produced within the standard EN14214. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
Reevaluation of the topographical anatomy of the mid‐thigh: A magnetic resonance and ultrasound imaging study
Authors: Torun Bilge Ipek , Balaban Mehtap , Hatipoglu Sukru Cem 
Published: July 2022

AbstractAdductor canal (AC) and sciatic nerve (SN) blockades are commonly used during total knee arthroplasties for postoperative pain control. Medical professionals have begun to utilize single injection combined regional anesthesia methods due to increased patient comfort. In this study, we examined the topographical anatomy of the mid‐thigh, which is recommended as the appropriate intervention level for combined AC and SN blockades, in order to provide a safe approach for clinicians. We examined 184 thigh magnetic resonance images (MRI) from 98 patients. We measured the diameter of the mid‐thigh, anterior thigh muscle thickness, subcutaneous adipose tissue thickness, and SN depth on the MRIs. We obtained ultrasound (US) images of the vastoadductor membranes (VAM) of 26 volunteers, and measured the vertical distances between the greater trochanter and the adductor tubercle (A) and the greater trochanter and the upper edge of the VAM (B). We then proportioned B to A in order to determine in which part of the thigh the AC was located. The AC was in the distal third of the thigh, and the SN's depth was located in the third quarter of the thigh's diameter. Only the adductor magnus, and no neurovascular structure, was at risk of injury between the AC and the SN. The upper edge of the VAM was 6.5 cm below the mid‐thigh, therefore it is not appropriate to suggest performing an AC blockade at mid‐thigh. We think that it is safe to perform a combined AC and SN blockade in a single injection in selected patients.
Flavonoid extract Kushenol a exhibits anti‐proliferative activity in breast cancer cells via suppression of PI3K/AKT/mTOR pathway
Authors: Liu Tao , Gong Jinhua , Lai Guobin , Yang Yichao , Wu Xiaoan , Wu Xiuping 
Published: July 2022

AbstractBackgroundKushenol A is natural flavonoid extract discovered in recent years, with potential anti‐tumor activity. Its role in breast cancer is poorly understood.MethodsTo investigate biological function of Kushenol A in breast cancer (BC), Cell Counting Kit‐8 assay, colony formation assay, flow cytometry, western blotting, qPCR analysis, and xenograft mouse model were performed.ResultsWe found that Kushenol A treatment reduced proliferative capability and induced G0/G1 phase cell cycle arrest and apoptosis of BC cells in a concentration‐dependent manner. Besides, Kushenol A treatment contributed to the upregulation of apoptosis‐related and cell cycle‐associated genes. In nude mice, Kushenol A administration repressed BC xenograft tumor growth. Mechanistically, phosphorylation levels of AKT and mTOR were markedly attenuated in Kushenol A‐treated BC cells; however, there were no significant differences in total AKT and mTOR expressions. Moreover, PI3K inhibitor combined with Kushenol A exhibited synergistic inhibitory activity on cell proliferation.ConclusionsTaken together, our findings suggested that Kushenol A suppressed BC cell proliferation by modulating PI3K/AKT/mTOR signaling pathway. Kushenol A may be a promising therapeutic drug for treating BC.
Sterically Controlled Late‐Stage Functionalization of Bulky Phosphines
Authors: Deng Hao , Bengsch Marco , Tchorz Nico , Neumann Constanze N. 
Published: July 2022

AbstractThe fine‐tuning of metal‐phosphine‐catalyzed reactions relies largely on accessing ever more precisely tuned phosphine ligands by de‐novo synthesis. Late‐stage C−H functionalization and diversification of commercial phosphines offers rapid access to entire libraries of derivatives based on privileged scaffolds. But existing routes, relying on phosphorus‐directed transformations, only yield functionalization of C
−H bonds in a specific position relative to phosphorus. In contrast to phosphorus‐directed strategies, herein we disclose an orthogonal functionalization strategy capable of introducing a range of substituents into previously inaccessible positions on arylphosphines. The strongly coordinating phosphine group acts solely as a bystander in the sterically controlled borylation of bulky phosphines, and the resulting borylated phosphines serve as the supporting ligands for palladium during diversification through phosphine self‐assisted Suzuki‐Miyaura reactions.