bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations, overlaps and dissociations between apathy and fatigue
Authors: Daumas Lyne , Corbel Camille , Zory Raphaël , Corveleyn Xavier , Fabre Roxane , Robert Philippe , Manera Valeria 
Published: May 2022

AbstractApathy and fatigue have a high prevalence in many pathological populations, but they are also present in healthy adults. The relationship between apathy and fatigue, which are both multidimensional, is still poorly understood. This study aims to describe the associations between the subdimensions of both apathy and fatigue and to investigate their overlaps and dissociations in healthy people. 729 participants (mean age = 30.8 ± 10.7 years) completed online self-assessment questionnaires. The Apathy Motivation Index and Dimensional Apathy Scale were used to assess apathy. The Multidimensional Fatigue Inventory was used to assess fatigue. The executive dimension of apathy showed the strongest correlations with mental fatigue and the two appeared to be underpinned by the same latent factor, according to exploratory factor analysis (EFA). The factor structure of EFA showed overlaps between behavioral apathy and both reduced motivation and activity in fatigue. Emotional and social dimensions of apathy were separately underpinned by a latent factor that comprised no items of fatigue. Apathy and fatigue have reduced activity and mental difficulties in common, whereas emotional and social disorders distinguish apathy from fatigue. This has important implications for assessing apathy and fatigue in the general population, and may be relevant for clinical practice.
Reconstruction of maxillofacial bone defects using patient-specific long-lasting titanium implants
Authors: Lim Ho-Kyung , Choi Young-Jun , Choi Won-Cheul , Song In-Seok , Lee Ui-Lyong 
Published: May 2022

AbstractThe objective of this retrospective study is to verify the effectiveness and safety of patient-specific titanium implants on maxillofacial bones, with a long-term follow-up. Total 16 patients with various maxillofacial defects underwent reconstruction using patient-specific titanium implants. Titanium implants, manufactured by electron beam melting, selective laser sintering, or milling, were inserted into the maxilla, mandible, or zygoma. Long-term follow‐up (36.7 ± 20.1 months) was conducted after the surgery. Bone fusion of the titanium implant body, postoperative infection, implant malunion, functional results, patient satisfaction, subsidence, osteolysis around the implants, and complications were recorded and analyzed at the last follow-up. Of the 28 implants, only one failed to unite with the bone; therefore, revision surgery was performed. No osteolysis or subsidence around the titanium implants nor adverse events were observed; the mean VAS score for satisfaction was 9. All patients enrolled in this trial were esthetically and functionally satisfied with their surgical results, and fixation failure and esthetic dissatisfaction complications were well resolved. Patient-specific titanium showed satisfactory outcomes when used to treat various oral and maxillofacial defects. A 3D printed titanium implant can be effectively used in the reconstruction of the zygoma and mandible instead of autogenous bone without donor site morbidity.
Axial myopia, a protective factor for diabetic retinopathy-role of vascular endothelial growth factor
Authors: Kulshrestha Ashish , Singh Nirbhai , Moharana Bruttendu , Gupta Parul Chawla , Ram Jagat , Singh Ramandeep 
Published: May 2022

AbstractLong axial length is one of the ocular protective factors in development of diabetic retinopathy (DR). In this study we examined the effect of axial length (AL) on aqueous humor vascular endothelial growth factor (VEGF) levels in patients with diabetes mellitus with or without DR. Forty-eight eyes of 48 participants were divided into three groups of 16 each. Group A consisted of non-diabetic patients, Group B had diabetic patients without DR, and Group C had diabetic patients with treatment-naive non-proliferative DR (NPDR). The groups were further subdivided based on axial lengths i.e., AL ≤ 23.30 mm (A1, B1, C1) and AL > 23.30 mm (A2, B2, C2). Undiluted aqueous humor was obtained during cataract surgery to measure the VEGF levels. We observed significant decrease in VEGF concentration in patients with AL ≥ 23.30 mm as compared with AL ≤ 23.30 mm in non-diabetic as well as diabetic patients. As the eye elongates, there is less secretion of VEGF in non-diabetics as well in diabetics with or without DR. Our findings strengthened the concept that an increase in AL leads to less VEGF in diabetic eyes, thus leading to less severe DR changes.
Diagnostic performance of oral swab specimen for SARS-CoV-2 detection with rapid point-of-care lateral flow antigen test
Authors: Mane Arati , Jain Shilpa , Jain Ankita , Pereira Michael , Sirsat Atul , Pathak Gaurav , Bhoi Vikalp , Bhavsar Shailaja , Panda Samiran 
Published: May 2022

AbstractWe evaluated the performance of oral swab specimen both health-care worker (HCW) collected and self-collected for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) detection with rapid antigen test (RAT) as compared to reverse transcriptase polymerase chain reaction (RT-PCR). Of the 529 participants enrolled, 121 (22.8%) were RT-PCR positive. Among the RT-PCR positives, 62 (51.2%) were RAT positive using oral swab. When compared with RT-PCR, RAT with oral swab had sensitivity and specificity of 63.3 and 96.8% respectively among symptomatic individuals. No statistically significant difference was observed in RAT positivity with HCW collection and self-collection, p = 0.606. Ct values were significantly lower in RT-PCR and RAT positive samples (ORF gene: 18.85 ± 4.36; E gene: 18.72 ± 4.84) as compared to RT-PCR positive and RAT negative samples (ORF gene: 26.98 ± 7.09; E gene: 26.97 ± 7.07), p < 0.0001. Our study demonstrated moderate sensitivity of RAT with oral swab in symptomatic individuals. Oral swab was the preferred sampling by almost all participants in terms of convenience and comfort as compared to nasopharyngeal swab. Oral swabs have utility for SARS-CoV-2 antigen detection among symptomatic individuals residing in remote rural areas and can serve as an initial screening tool during COVID-19 spikes when cases rise exponentially and laboratory capacities for RT-PCR testing become overwhelmed.
Coherence resource power of isocoherent states
Authors: Losada Marcelo , Bosyk Gustavo M. , Freytes Hector , Sergioli Giuseppe 
Published: May 2022

AbstractWe address the problem of comparing quantum states with the same amount of coherence in terms of their coherence resource power given by the preorder of incoherent operations. For any coherence measure, two states with null or maximum value of coherence are equivalent with respect to that preorder. This is no longer true for intermediate values of coherence when pure states of quantum systems with dimension greater than two are considered. In particular, we show that, for any value of coherence (except the extreme values, zero and the maximum), there are infinite incomparable pure states with that value of coherence. These results are not peculiarities of a given coherence measure, but common properties of every well-behaved coherence measure. Furthermore, we show that for qubit mixed states there exist coherence measures, such as the relative entropy of coherence, that admit incomparable isocoherent states.
Multiple sclerosis genetic and non-genetic factors interact through the transient transcriptome
Authors: Umeton Renato , Bellucci Gianmarco , Bigi Rachele , Romano Silvia , Buscarinu Maria Chiara , Reniè Roberta , Rinaldi Virginia , Pizzolato Umeton Raffaella , Morena Emanuele , Romano Carmela , Mechelli Rosella , Salvetti Marco , Ristori Giovanni 
Published: May 2022

AbstractA clinically actionable understanding of multiple sclerosis (MS) etiology goes through GWAS interpretation, prompting research on new gene regulatory models. Our previous investigations suggested heterogeneity in etiology components and stochasticity in the interaction between genetic and non-genetic factors. To find a unifying model for this evidence, we focused on the recently mapped transient transcriptome (TT), that is mostly coded by intergenic and intronic regions, with half-life of minutes. Through a colocalization analysis, here we demonstrate that genomic regions coding for the TT are significantly enriched for MS-associated GWAS variants and DNA binding sites for molecular transducers mediating putative, non-genetic, determinants of MS (vitamin D deficiency, Epstein Barr virus latent infection, B cell dysfunction), indicating TT-coding regions as MS etiopathogenetic hotspots. Future research comparing cell-specific transient and stable transcriptomes may clarify the interplay between genetic variability and non-genetic factors causing MS. To this purpose, our colocalization analysis provides a freely available data resource at www.mscoloc.com.
Characteristics of summer hourly precipitation under different urbanization background in central China
Authors: Tang Yonglan , Xu Guirong , Wan Rong , Wang Xiaofang 
Published: May 2022

AbstractThe relationship between sub-daily precipitation and urbanization is widely concerned because short-term precipitation is sensitive to urbanization and difficult to predict. Using the data of summer hourly precipitation and urban development during 2007–2019 at four urban stations and an atmospheric background monitoring station in central China, this study investigates the characteristics of hourly precipitation and hourly extreme precipitation (HEP) under different urbanization background. It is found that high urbanization level may benefit precipitation intensity but not for accumulated precipitation amount and precipitation frequency, and it is also conducive to the occurrence of hourly precipitation within [20, 50) mm. Precipitation amount and frequency for hourly precipitation within [5, 50) mm have similar diurnal variation at fixed station, yet the diurnal variation of precipitation intensity is insignificant. The differences in temporal variation of precipitation are related to urbanization and terrain. Both high urbanization level and speed are conducive to summer HEP; especially summer HEP intensity may increase gradually under sustainable urbanization development. Although growth-type HEP occurs frequently with main contribution to total HEP precipitation amount in central China regardless of urbanization level, the frequency and contribution of continuous-type HEP tends to increase under high urbanization level and speed.
A systematic review and meta-analysis of fusion rate enhancements and bone graft options for spine surgery
Authors: Tavares Wagner M. , de França Sabrina Araujo , Paiva Wellingson S. , Teixeira Manoel J. 
Published: May 2022

AbstractOur study aimed to evaluate differences in outcomes of patients submitted to spinal fusion using different grafts measuring the effectiveness of spinal fusion rates, pseudarthrosis rates, and adverse events. Applying the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, this systematic review and meta-analysis identified 64 eligible articles. The main inclusion criteria were adult patients that were submitted to spinal fusion, autologous iliac crest (AIC), allograft (ALG), alloplastic (ALP; hydroxyapatite, rhBMP-2, rhBMP-7, or the association between them), and local bone (LB), whether in addition to metallic implants or not, was applied. We made a comparison among those groups to evaluate the presence of differences in outcomes, such as fusion rate, hospital stay, follow-up extension (6, 12, 24, and 48 months), pseudarthrosis rate, and adverse events. Sixty-four studies were identified. LB presented significantly higher proportions of fusion rates (95.3% CI 89.7–98.7) compared to the AIC (88.6% CI 84.8–91.9), ALG (87.8% CI 80.8–93.4), and ALP (85.8% CI 75.7–93.5) study groups. Pseudarthrosis presented at a significantly lower pooled proportion of ALG studies (4.8% CI 0.1–15.7) compared to AIC (8.6% CI 4.2–14.2), ALP (7.1% CI 0.9–18.2), and LB (10.3% CI 1.8–24.5). ALP and AIC studies described significantly more cases of adverse events (80 events/404 patients and 860 events/2001 patients, respectively) compared to LB (20 events/311 patients) and ALG (73 events/459 patients). Most studies presented high risk-of-bias scores. Based on fusion rates and adverse events proportions, LB showed a superior trend among the graft cases we analyzed. However, our review revealed highly heterogeneous data and a need for more rigorous studies to better address and assist surgeons’ choices of the best spinal grafts.
Non-canonical Wnt signaling participates in Jagged1-induced osteo/odontogenic differentiation in human dental pulp stem cells
Authors: Kornsuthisopon Chatvadee , Chansaenroj Ajjima , Manokawinchoke Jeeranan , Tompkins Kevin A. , Pirarat Nopadon , Osathanon Thanaphum 
Published: May 2022

AbstractOsteoblast differentiation requires the interaction of various cell signaling pathways to modulate cell responses. Notch and Wnt signaling are among the crucial pathways that control numerous biological processes, including osteo/odontogenic differentiation. The aim of the present study was to examine the involvement of Wnt signaling in the Jagged1-induced osteo/odontogenic differentiation in human dental pulp stem cells (hDPSCs). The Wnt-related gene expression was analyzed from publicly available data of Jagged1-treated human dental pulp cells. The mRNA expression of Wnt ligands (WNT2B, WNT5A, WNT5B, and WNT16) and Wnt inhibitors (DKK1, DKK2, and SOST) were confirmed using real-time polymerase chain reaction. Among the Wnt ligands, WNT2B and WNT5A mRNA levels were upregulated after Jagged1 treatment. In contrast, the Wnt inhibitors DKK1, DKK2, and SOST mRNA levels were downregulated. Recombinant WNT5A, but not WNT2B, significantly promoted in vitro mineral deposition by hDPSCs. Wnt signaling inhibition using IWP-2, but not DKK1, inhibited Jagged1-induced alkaline phosphatase (ALP) activity, mineralization, and osteo/odontogenic marker gene expression in hDPSCs. In conclusion, Jagged1 promoted hDPSC osteo/odontogenic differentiation by modulating the non-canonical Wnt pathway.
Experimental and theoretical evaluations on Oleuropein as a natural origin corrosion inhibitor for copper in acidic environment
Authors: Deyab M. A. , Mohsen Q. , Bloise E. , Lazzoi M. R. , Mele G. 
Published: May 2022

AbstractCopper corrosion in acidic cleaning solutions is a major worry for heat exchangers. Corrosion inhibitors derived from natural sources might be a viable option. The isolation of Oleuropein compound from olive leaf and investigation of its anticorrosion potential for copper in 1.0 M H2SO4solution are reported here. All experimental results from LC–MS, FT-IR,1H and13C-NMR characterizations support the molecular structure of Oleuropein. Electrochemical and gravimetric tests were used to evaluate the corrosion inhibition capabilities of Oleuropein. According to polarization investigation, Oleuropein is a mixed-type inhibitor. Oleuropein's inhibitory efficacy increases with concentration, attaining an optimum value (98.92%) at 100 mg L−1. At high temperatures, Oleuropein can be considered an efficient inhibitor. Thermodynamic variables for the activation operation and copper dissolution were computed and addressed as well. Scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) examinations revealed that Oleuropein produced an outer layer on the copper surface, shielding it from severe acid damage. Quantum chemical simulations were employed to propose molecular explanations for Oleuropein's inhibitory actions.
Factors affecting compliance with national accreditation essential safety standards in the Kingdom of Saudi Arabia
Authors: Althumairi Arwa , Alzahrani Amal , Alanzi Turki , Al Wahabi Salem , Alrowaie Summaya , Aljaffary Afnan , Aljabri Duaa 
Published: May 2022

AbstractAccreditation is a widespread culture internationally and nationally. The effectiveness of compliance with accreditation standards was positively correlated with health care settings’ performance in multiple aspects: leadership, professional performance, patient safety and organizational culture. There is limited knowledge of the national compliance rate with accreditation standards. Therefore, it is important to assess the hospital compliance with accreditation rate in the Kingdom Saudi Arabia (KSA) and its related factors. This paper presents a quantitative cross-sectional study. Data were extracted from the annual Essential Safety Requirement (ESR) survey database from the Central Board for Accreditation of Health care Institutions (CBAHI) research center during the period 2016 to 2018. Hospitals that started their operation after the first ESR survey round in 2016 or shut down during the study period were excluded. The hospital scoring was on a scale of 0 to 100 and classified as follows: score 2 if the hospital satisfactory compliance (Fully Met) was ≥ 80% and score 1 if particular compliance (Partially Met) was ≥ 50% to < 80%. Then, a score of 0 indicated insufficient compliance (Not Met) when < 50% and a score of not applicable (NA) if the standard does not apply to the hospital. A total of 437 hospitals were surveyed in 20 regions in the KSA and had an overall compliance rate on average that was higher among private hospitals than among public hospitals (77% vs. 66%). Overall, private hospitals had a significantly better compliance rate than public hospitals (mean rate = 84% vs. 68%, respectively, P = 0.019). Large hospitals had more compliance with some standards than smaller hospitals. After adjusting for the year of the survey report, the private hospital type was more compliant than the public hospital. This study supports mandatory accreditation programs for both public and private health sectors, with increased monitoring by the concerned parties (i.e., CBAHI and the Ministry of Health). The authors encourage the application of accreditation for specialized and independent health services.
Usefulness of the CHAMPS score for risk stratification in lower gastrointestinal bleeding
Authors: Tajika Munehiko , Matsuhashi Tamotsu , Shimodaira Yosuke , Fukuda Sho , Tsuji Tsuyotoshi , Sugawara Kae , Saruta Youhei , Takahashi Yasutaka , Watanabe Kenta , Iijima Katsunori 
Published: May 2022

AbstractWe have recently developed a simple prediction score, the CHAMPS score, to predict in-hospital mortality in patients with upper gastrointestinal bleeding. In this study, the primary outcome of this study was the usefulness of the CHAMPS score for predicting in-hospital mortality with lower gastrointestinal bleeding (LGIB). Consecutive adult patients who were hospitalized with LGIB at two tertiary academic medical centers from 2015 to 2020 were retrospectively enrolled. The performance for predicting outcomes with CHAMPS score was assessed by a receiver operating characteristic curve analysis, and compared with four existing scores. In 387 patients enrolled in this study, 39 (10.1%) of whom died during the hospitalization. The CHAMPS score showed good performance in predicting in-hospital mortality in LGIB patients with an AUC (95% confidence interval) of 0.80 (0.73–0.87), which was significantly higher in comparison to the existing scores. The risk of in-hospital mortality as predicted by the CHAMPS score was shown: low risk (score ≤ 1), 1.8%; intermediate risk (score 2 or 3), 15.8%; and high risk (score ≥ 4), 37.1%. The CHAMPS score is useful for predicting in-hospital mortality in patients with LGIB.
Foot–ankle therapeutic exercise program can improve gait speed in people with diabetic neuropathy: a randomized controlled trial
Authors: Monteiro Renan L. , Ferreira Jane S. S. P. , Silva Érica Q. , Cruvinel-Júnior Ronaldo H. , Veríssimo Jady L. , Bus Sicco A. , Sacco Isabel C. N. 
Published: May 2022

AbstractThis study sought to determine whether a foot–ankle therapeutic exercise program can improve daily physical activity (i.e. number of steps) and fast and self-selected gait speed in people with diabetic peripheral neuropathy (DPN). In this single-blind randomized controlled trial and intention-to-treat analysis, 78 volunteers with DPN were allocated into a control group, which received usual care, and an intervention group (IG), which received usual care plus a 12-week foot–ankle exercise program. The adherence at 12 weeks rate in the IG was 92.3% (36 participants) and the dropout was 5.1% in the control group (2 participants). The number of steps and self-selected gait speed did not change significantly in either group (p > 0.05), although a 1,365-step difference between groups were observed at 1-year followup. The 12-week foot–ankle therapeutic exercises improved significantly fast-gait speed (primary outcome) (p = 0.020), ankle range of motion (p = 0.048), and vibration perception (secondary outcomes) (p = 0.030), compared with usual-care at 12 weeks. At 24 weeks, the IG showed better quality of life than controls (p = 0.048). At 1-year, fast-gait speed and vibration perception remained higher in the IG versus controls. Overall, the program may be a complementary treatment strategy for improving musculoskeletal and functional deficits related to DPN.Trial registrationClinicalTrials.gov NCT02790931 (06/06/2016).
Normalized unitary synaptic signaling of the hippocampus and entorhinal cortex predicted by deep learning of experimental recordings
Authors: Moradi Keivan , Aldarraji Zainab , Luthra Megha , Madison Grey P. , Ascoli Giorgio A. 
Published: May 2022

AbstractBiologically realistic computer simulations of neuronal circuits require systematic data-driven modeling of neuron type-specific synaptic activity. However, limited experimental yield, heterogeneous recordings conditions, and ambiguous neuronal identification have so far prevented the consistent characterization of synaptic signals for all connections of any neural system. We introduce a strategy to overcome these challenges and report a comprehensive synaptic quantification among all known neuron types of the hippocampal-entorhinal network. First, we reconstructed >2600 synaptic traces from ∼1200 publications into a unified computational representation of synaptic dynamics. We then trained a deep learning architecture with the resulting parameters, each annotated with detailed metadata such as recording method, solutions, and temperature. The model learned to predict the synaptic properties of all 3,120 circuit connections in arbitrary conditions with accuracy approaching the intrinsic experimental variability. Analysis of data normalized and completed with the deep learning model revealed that synaptic signals are controlled by few latent variables associated with specific molecular markers and interrelating conductance, decay time constant, and short-term plasticity. We freely release the tools and full dataset of unitary synaptic values in 32 covariate settings. Normalized synaptic data can be used in brain simulations, and to predict and test experimental hypothesis.