bluuebunny/crossref_metadata_2025_split huggingface dataset:
Goal management training and psychoeducation / mindfulness for treatment of executive dysfunction in Parkinson’s disease: A feasibility pilot trial
Authors: Giguère-Rancourt Ariane , Plourde Marika , Racine Eva , Couture Marianne , Langlois Mélanie , Dupré Nicolas , Simard Martine 
Published: February 2022

Introduction
As there is currently no pharmacological treatment for Parkinson’s Disease Mild Cognitive Impairment (PD-MCI) with executive dysfunctions, specific cognitive interventions must be investigated. Most previous studies have tested bottom-up cognitive training programs but have not shown very good results.

Objectives
The aim of this study was to test ease of implementation, differential safety and preliminary efficacy of two top-down (strategy-learning) home-based, individualized, cognitive interventions: Goal Management Training (GMT), adapted for PD-MCI (Adapted-GMT), and a psychoeducation program combined with mindfulness exercises (PSYCH-Mind).

Methods
This was a single-blind block-randomized between-group comparative study. Twelve PD-MCI with mild executive dysfunctions were divided in four blocks and randomly assigned to any of the two interventions. The participants were included if they had PD-MCI diagnosis (no dementia), with stabilized medication. Both groups (Adapted-GMT and PSYCH-mind) received five intervention sessions each lasting 60–90 minutes for five weeks. Measures were collected at baseline, mid-point, one-week, four-week and 12-week follow-ups. Executive functions were assessed with the Dysexecutive questionnaire (DEX) and the Zoo Map Test (ZMT). Quality of life (QoL) and psychiatric symptoms were also evaluated. Repeated measures ANCOVAs (mixed linear analysis) were applied to all outcomes.

Results
There was one drop out, and both interventions were feasible and acceptable. Despite the small sample size limiting statistical power, patients of both groups significantly improved executive functions per the DEX-patient (Time: F(4,36) = 2.96, p = 0.033, CI95%: 10.75–15.23) and DEX-caregiver scores (Time: F(4,36) = 6.02, p = 0.017, CI95%: 9.63–17.23). Both groups significantly made fewer errors between measurement times on the ZMT (Time: F(3,36) = 16.66, p = 0.001, CI95%: 1.07–2.93). However, QoL significantly increased only in PSYCH-Mind patients at four-week follow-up (interaction Time*Group: F(4,36) = 5.31, p = 0.002, CI95%: 15.33–25.61).

Conclusion
Both interventions were easily implemented and proved to be safe. Because both interventions are arguably cost-effective, these pilot findings, although promising, need to be replicated in large samples.

ClinicalTrials.gov Identifier
NCT04636541.
Can social support buffer the association between loneliness and hypertension? a cross-sectional study in rural China
Authors: Yazawa Aki , Inoue Yosuke , Yamamoto Taro , Watanabe Chiho , Tu Raoping , Kawachi Ichiro 
Published: February 2022

ObjectivesHypertension has reached epidemic levels in rural China, where loneliness has been a major problem among community dwellers as a consequence of rural-to-urban migration among younger generations. The objective of the study is to investigate the association between loneliness and hypertension, and whether social support can buffer the association (i.e., stress buffering theory), using cross-sectional data from 765 adults (mean age: 59.1 years) in rural Fujian, China.MethodsSocial support was measured as the reciprocal instrumental social support from/to neighbors and the reciprocal emotional support (i.e., the number of close friends that the respondent could turn to for help immediately when they are in trouble). A mixed-effect Poisson regression model with a robust variance estimator was used to investigate the association between loneliness, social support, and hypertension.ResultsAnalysis revealed that those who were lonely had a higher prevalence ratio for hypertension (prevalence ratio = 1.12, 95% confidence interval 0.99–1.26) compared to those who reported not being lonely. There was an interaction between social support and loneliness in relation to hypertension. Specifically, contrary to the stress buffering theory, the positive association between loneliness and hypertension was more pronounced among those who reported higher social support compared to those who reported lower support (pfor interaction <0.001 for instrumental support).ConclusionThe results suggest that being lonely despite high levels of social support poses the greatest risk for hypertension. This study did not confirm a buffering effect of social support on the association between loneliness and hypertension.
Comparative Analysis of Factors Affecting the Underpricing Level of Sharia and Non Sharia Stocks at the time of Initial Public Offering
Authors: Hidayah Lia , Sunarsih Sunarsih 
Published: February 2022

Underpricing is a condition where the stock price of a company when conducting an Initial Public Offering (IPO) is below the stock price when it is on secondary market. In Indonesia, stocks are divided into two types, namely Sharia stock and non Sharia stock. This study aims to determine the effect of underwriter reputation, investment risk, profitability, financial laverage, and company size on the level of underpricing of Sharia stock and non Sharia stock. The sampling technique used was purposive sampling. The analytical method used is linear multiple regression with the type of cross section data. The results of the study found that there are differences that effect the underpricing of Sharia stock and non Sharia stock. In Sharia stock, underpricing is only influenced by financial laverage, while in non Sharia stock underpricing is influenced by investment risk and company size. This study provides an overview to investors who have the aim of investing in companies that are IPOs for profit so that they carefully consider the influence of underwriter variables, investment risk, company size, financial laverage, and profitability. For companies, this research provides an overview to companies in order to make the right decisions in offering optimal stock prices. And for further researchers,
No association of natural killer cell number and function in peripheral blood with overweight/obesity and metabolic syndrome in a cohort of young women
Authors: Keilen Julia , Gar Christina , Rottenkolber Marietta , Fueessl Louise U. , Joseph Anna T. , Draenert Rika , Seissler Jochen , Lechner Andreas 
Published: February 2022

AbstractAimTo reexamine the associations of NK cell number and function in the peripheral blood with overweight/obesity and the metabolic syndrome in a large, well‐phenotyped human cohort.MethodsCross‐sectional analysis of 273 women in the PPSDiab Study; measurement of absolute and relative number of NK cells in peripheral blood, and of functional parameters CD69 positivity and cytotoxicity against K562 cells; group comparison of NK cell characteristics between lean, overweight, and obese participants, as well as metabolic syndrome scores of 0, 1, 2, and ≥3; Spearman correlation analyses to clinical parameters related to the metabolic syndrome.ResultsWe found no differences in NK cell number and function between lean, overweight, and obese women (relative NK cell number (median (Q1–Q3), [%]) 5.1(2.6–9.4) vs. 4.8 (2.9–8.4) vs. 3.8 (1.7–7.8), p = 0.187; absolute NK cell number [106/L]: 86.9 (44.6–188.8) vs. 92.6 (52.5–154.6) vs. 85.9 (44–153.8), p = 0.632; CD69+ [%]: 27.2 (12.9–44.3) vs. 37.6 (13.2–52.8) vs. 33.6 (16.3–45), p = 0.136; cytotoxicity [%]: 11.0 (7.1–14.5) vs. 8.5 (6.4–13.2) vs. 11.3 (8.7–14.2), p = 0.094), as well as between different metabolic syndrome scores. Nonesterified fatty acids correlated with absolute and relative NK cell number and cytotoxicity (ρ [p‐value]: 0.142 [0.021], 0.119 [0.049], and 0.131 [0.035], respectively). Relative NK cell number further correlated with high‐density lipoprotein cholesterol (0.144 [0.018]) and cytotoxicity with 2 h glucose in oral glucose tolerance testing (0.132 [0.034]). CD69 positivity correlated with body fat (0.141 [0.021]), triglycerides (0.129 [0.033]), and plasma leptin (0.155 [0.010]). After correction for multiple testing, none of the associations remained significant.ConclusionIn the present study, we observed no associations of NK cell number and function in the peripheral blood with overweight/obesity and the metabolic syndrome. Extreme phenotypes of obesity and the metabolic syndrome might have caused differing results in previous studies. Further analyses with a focus on compartments other than peripheral blood may help to clarify the relation between NK cells and metabolic diseases.
The glucose lowering effects of CL 316,243 dissipate with repeated use and are rescued by cilostamide
Authors: Medak Kyle D. , McKie Greg L. , Shamshoum Hesham , Seguin Ian , Wright David C. 
Published: February 2022

AbstractRepeated activation of the beta 3 adrenergic receptor (β3AR) with the agonist CL 316,243 (CL) results in remodeling of white adipose tissue (WAT) characterized by increased mitochondrial enzymes and expression of uncoupling protein 1 (UCP1). β3AR activation also has profound acute metabolic effects including rapidly decreasing blood glucose, secondary to fatty acid‐induced increases in insulin, and increasing energy expenditure. The acute (single dose) effects of β3AR activation have largely been examined in treatment naive animals and under room temperature housing conditions. The current study examined if repeated CL treatment would lead to an attenuation of acute metabolic effects of CL treatment under thermoneutral housing conditions and if this could be rescued with cilostamide, a phosphodiesterase inhibitor. We provide evidence demonstrating that the acute effects of CL to increase serum fatty acids and insulin and reduce blood glucose, but not increases in energy expenditure, are attenuated in mice following repeated treatment with CL. This occurs in parallel with reductions in indices of protein kinase A signaling in WAT including the phosphorylation of hormone sensitive lipase. The findings of attenuated serum fatty acid, insulin, and blood glucose responses were confirmed in both high‐fat fed and UCP1−/− mice repeatedly treated with CL. Desensitization to CL in mice was rescued by cilostamide. Herein, we provide evidence that the glucose lowering, but not thermogenesis inducing, effects of CL are attenuated with repeated treatment and can be rescued by cilostamide. The findings of this study point toward novel adjunct treatment approaches that could be used to maximize therapeutic, glucose lowering effects of β3AR agonists.
Linear recurrent relations, power series distributions, and generalized allocation scheme
Authors: Timashev Aleksandr N. 
Published: February 2022

Abstract
We consider distributions of the power series type determined by the generating functions of sequences satisfying linear recurrence relations with nonnegative coefficients. These functions are represented by power series with positive radius of convergence. An integral limit theorem is proved on the convergence of such distributions to the exponential distribution. For the generalized allocation scheme generated by these linear relations a local normal theorem for the total number of components is proved. As a consequence of more general results of the author, a limit theorem is stated containing sufficient conditions under which the distributions of the number of components having a given volume converge to the Poisson distribution.
Enabling data-centric AI through data quality management and data literacy
Authors: Abedjan Ziawasch 
Published: February 2022

Abstract
Data is being produced at an intractable pace. At the same time, there is an insatiable interest in using such data for use cases that span all imaginable domains, including health, climate, business, and gaming. Beyond the novel socio-technical challenges that surround data-driven innovations, there are still open data processing challenges that impede the usability of data-driven techniques. It is commonly acknowledged that overcoming heterogeneity of data with regard to syntax and semantics to combine various sources for a common goal is a major bottleneck. Furthermore, the quality of such data is always under question as the data science pipelines today are highly ad-hoc and without the necessary care for provenance. Finally, quality criteria that go beyond the syntactical and semantic correctness of individual values but also incorporate population-level constraints, such as equal parity and opportunity with regard to protected groups, play a more and more important role in this process. Traditional research on data integration was focused on post-merger integration of companies, where customer or product databases had to be integrated. While this is often hard enough, today the challenges aggravate because of the fact that more stakeholders are using data analytics tools to derive domain-specific insights. I call this phenomenon the democratization of data science, a process, which is both challenging and necessary. Novel systems need to be user-friendly in a way that not only trained database admins can handle them but also less computer science savvy stakeholders. Thus, our research focuses on scalable example-driven techniques for data preparation and curation. Furthermore, we believe that it is important to educate the breadth of society on implications of a data-driven world and actively promote the concept of data literacy as a fundamental competence.
The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
Authors: Fredy Diana Marsha , Harpin Darwin , Mihardja Hasan 
Published: February 2022

Abstract

Objectives
The aim of this literature review is to describe the role of acupuncture for myofascial pain syndrome in interventional pain management.

Content
Myofascial pain syndrome (MPS) can be found at all ages. Approximately 30.0–93.0% of patients with musculoskeletal pain have MPS. Unsuccessful treatment can lead to dysfunction, disability, and a cost burden. We conducted a search of studies published in Google Scholar and PubMed databases from 2016 to 2021.

Summary
Acupuncture, combined with other therapies, is effective in reducing pain and improving physical function. Acupuncture can enhance endogenous opioids such as endorphins to relieve pain and enhance the healing process.

Outlook
Acupuncture could be considered as one of nonpharmacological options in Interventional Pain Management for MPS. Interventions with acupuncture are safe and have minimal side effects when performed by a trained and competent practitioner.
Assessing the United States’ most frequently asked questions about osteopathic medicine, osteopathic education, and osteopathic manipulative treatment
Authors: Sajjadi Nicholas B. , Ottwell Ryan , Shepard Samuel , Bray Natasha , Dyer Robin , Wilson Jennifer , Vassar Matt , Hartwell Micah 
Published: February 2022

Abstract

Context
Osteopathic medicine in the United States continues to produce a substantial number of physicians and medical educators. However, recently popularized misconceptions about osteopathic medical practice, education, and manual therapy suggest an unsettling prevalence of inaccurate beliefs held by the public. The public often searches the internet to find out information about osteopathic medicine, but the content of questions and the transparency of the resulting information is unknown.

Objectives
We sought to explore frequently asked questions (FAQs) generated by Google to assess commonly searched questions about the osteopathic profession and to determine the level of information transparency associated with resulting sources.

Methods
On June 16, 2021, we searched Google for three terms: “osteopathic medicine,” “doctor of osteopathic medicine,” and “DO,” until a minimum of 100 FAQs and their answer links were extracted from each search. After excluding irrelevant FAQs, we used Rothwell’s Classification of Questions to categorize the FAQs. We then used the Journal of the American Medical Association’s Benchmark Criteria to assess information transparency for each corresponding answer source provided by Google. The answer sources were screened for the inappropriate use of “osteopathy” in place of “osteopathic medicine” and for “osteopath” in place of “DO,” “Doctor of Osteopathic Medicine,” or “Osteopathic Physician.” We performed statistical tests to ascertain the differences in information transparency between osteopathic and nonosteopathic information sources.

Results
Our Google search revealed 110 unique FAQs about osteopathic medicine. The majority of FAQs were classified as fact-based (82/110; 74.55%), nearly half of which (45.12%) were related to the medical practicing privileges of DOs. The FAQs were most commonly answered by academic institutions (44/110, 40.0%). Nearly half (49.09%) of the linked answer sources were deemed inadequate by JAMA benchmark criteria. Of the 110 linked answer sources, 19 (17.27%) misused either osteopathy, osteopath, or both to describe osteopathic physicians. Only 30 sources were linked to US-based osteopathic organizations. Osteopathic organizations were statistically less likely to meet high-transparency criteria than nonosteopathic organizations (p=0.002).

Conclusions
Our study shows that the US public may be unsure about the physician status of DOs, which may prevent securing the professional identity of osteopathic physicians in the eyes of the public. Osteopathic organizations should tailor awareness campaigns toward addressing the common misconceptions revealed by our study. Osteopathic organizations should use transparency criteria as a rubric when publishing information to enhance transparency.
A pan-cancer analysis of the oncogenic role of Holliday junction recognition protein in human tumors
Authors: Su Rong , Huang Hechen , Gao Xingxing , Zhou Yuan , Yin Shengyong , Xie Haiyang , Zhou Lin , Zheng Shusen 
Published: February 2022

Abstract
Although cell-based or animal-based research evidence support the association of Holliday junction recognition protein (HJURP) with cancers, no pan-cancer investigation has been reported. The datasets of Gene Expression Omnibus database along with The Cancer Genome Atlas project were used to evaluate the expression of HJURP in various types of tumors. HJURP is overexpressed in a considerable number of cancers, and some changes in DNA methylation and genetic alterations are discovered in some types of tumors, such as kidney-related and adrenal gland-related tumors. Based on PrognoScan and gene expression profiling interactive analysis (GEPIA), the elevated expression of HJURP worsened the survival time of individuals with cancer. The biological general repository for interaction datasets (BioGRID) and The database for annotation, visualization and integrated discovery (DAVID) were used to establish the functional molecular network. It revealed that the cell cycle and p53 signaling pathway are the key molecular mechanisms that HJURP promotes carcinogenesis. The nomograms between HJURP and clinical pathological factors based on the Cox proportional hazards model showed a good prognostic performance in kidney carcinoma, hepatocellular carcinoma, and lung adenocarcinoma. Our first pan-cancer study provides a relatively profound insights into the oncogenic roles of HJURP across different tumors.
Radiation increases COL1A1, COL3A1, and COL1A2 expression in breast cancer
Authors: Yao Guorong , Zhao Kaiyue , Bao Kaikai , Li Jing 
Published: February 2022

Abstract

Background
Radiotherapy-associated secondary cancer is an important issue for the treatment of breast cancer (BCa). This study aimed to investigate the molecular mechanism and genetic risk factors for radiation-associated secondary diseases in BCa.

Methods
The differentially expressed genes (DEGs) between preradiation and postradiation BCa samples in the GSE65505 dataset were obtained. The pathways related to the radiation-associated DEGs in the protein–protein interaction (PPI) network modules were identified. miRNAs targeted to the key genes in the PPI network were identified, and their association with BCa prognosis was analyzed.

Results
A total of 136 radiation-associated DEGs preradiation and postradiation BCa samples were screened out. The PPI network consisted of a significant module that consisted of 21 upregulated DEGs that were associated with “hsa04512: ECM–receptor interaction,” “hsa04151: PI3K-Akt signaling pathway,” and “hsa04115: p53 signaling pathway.” Sixteen DEGs, including three collagen genes collagen type I alpha 1 chain (COL1A1), COL3A1, and COL1A2, were enriched in 17 radiation-associated pathways. The three genes were upregulated in BCa tissues compared with controls and were also elevated by radiation. They were targeted by hsa-miR-29a/c, and the expression levels of hsa-miR-29a/c were associated with a poor prognosis of BCa.

Conclusions
The upregulation of COL1A1, COL3A1, and COL1A2 might be genetic risk factors for radiation-associated secondary diseases in BCa.
A large-scale single-mode array laser based on a topological edge mode
Authors: Ishida Natsuko , Ota Yasutomo , Lin Wenbo , Byrnes Tim , Arakawa Yasuhiko , Iwamoto Satoshi 
Published: February 2022

Abstract
Topological lasers have been intensively investigated as a strong candidate for robust single-mode lasers. A typical topological laser employs a single-mode topological edge state, which appears deterministically in a designed topological bandgap and exhibits robustness to disorder. These properties seem to be highly attractive in pursuit of high-power lasers capable of single mode operation. In this paper, we theoretically analyze a large-scale single-mode laser based on a topological edge state. We consider a sizable array laser consisting of a few hundreds of site resonators, which support a single topological edge mode broadly distributed among the resonators. We build a basic model describing the laser using the tight binding approximation and evaluate the stability of single mode lasing based on the threshold gain difference Δα between the first-lasing edge mode and the second-lasing competing bulk mode. Our calculations demonstrate that stronger couplings between the cavities and lower losses are advantageous for achieving stable operation of the device. When assuming an average coupling of 100 cm−1 between site resonators and other realistic parameters, the threshold gain difference Δα can reach about 2 cm−1, which would be sufficient for stable single mode lasing using a conventional semiconductor laser architecture. We also consider the effects of possible disorders and long-range interactions to assess the robustness of the laser under non-ideal situations. These results lay the groundwork for developing single-mode high-power topological lasers.
The crystal structure of [(2,2′-bipyridine-k2
N,N)-bis(6-phenylpyridine-2-carboxylate-k2
N,O)copper(II)], C34H24N4O4Cu
Authors: Yi-Min Feng , Xi-Shi Tai , Yu-Pei Xia 
Published: February 2022

Abstract
C34H24N4O4Cu, monoclinic, C2/c (no. 15), a = 17.2931(15) Å, b = 10.3584(5) Å, c = 17.5641(16) Å, β = 120.180(12)°, V = 2719.8(5) Å3, Z = 4, R

gt
(F) = 0.0282, wR
ref(F
2) = 0.0681, T = 199.99(10) K.