bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel therapeutic approach for reducing postoperative inflammatory complications after impacted mandibular third molar removal
Authors: Altaweel Alaa Abdelqader , El-Hamid Gaber Abd , Alnaffar Mahmoud Z. , Almowallad Abdulrahman S. , Almech Mohamad H. , Almuwallad Abeer S. , Alharbi Rawan K. , Arab Wasan A. 
Published: September 2022

Background:
This study was designed to compare effect of combined use of dexamethasone and honey versus each agent alone in controlling complications associated with removal of impacted mandibular third molar.

Methods:
This randomized clinical study included patients suffering from impacted mandibular wisdom teeth. Patients were divided randomly into 4 groups. Group I, control, group II, received dexamethasone injection preoperatively, group III, received honey locally in the wound after extraction, and group IV, received dexamethasone injection preoperatively and topical honey application. All patients were evaluated preoperatively and postoperatively to assess facial edema, interincisal distance, pain, and total analgesic dose used.

Results:
Significant edema developed in group I than other groups and improved significantly in group II and III on seventh postoperative day, and tenth postoperative day in group I. Insignificant edema developed in group IV. Significant decrease in interincisal distance occurred in all groups on third postoperative day that improved significantly on seventh postoperative days in all groups except group I, it improved on tenth postoperative day. Pain was significantly minimum in group IV than other groups and its maximum degree was in group I.

Conclusion:
Both dexamethasone and honey are an effective way of minimizing swelling, pain, and trismus after removal of impacted lower third molars. Both agents either alone or in combination provide simple, safe, painless, and cost-effective method to eliminate postoperative discomfort. However, dexamethasone or honey can decrease complications related to surgical extraction of mandibular third molar, the simultaneous application of both agents is more effective method in this regard.
Clinical significance of securin expression in solid cancers: A PRISMA-compliant meta-analysis of published studies and bioinformatics analysis based on TCGA dataset
Authors: Liu Xiang , Zeng Wei , Zheng Dayang , Tang Min , Zhou Wangyan 
Published: September 2022

Background:
Numerous studies have investigated the clinical significance of securin expression in solid cancers; however, the results have been inconsistent. Hence, we performed a meta-analysis of published studies to assess the clinical value of securin expression in patients with solid cancers.

Methods:
The Chinese National Knowledge Infrastructure, Web of Science, PubMed, and EMDASE databases were searched for eligible studies (from inception up to April 2021). Bioinformatics analysis based on The Cancer Genome Atlas dataset was also performed to evaluate the prognostic value of securin expression.

Results:
A total of 25 articles with 26 studies were included in the meta-analysis. The results of the meta-analysis implied that high securin expression was positively correlated with unfavorable overall survival (OS) (hazard ratio = 1.52, 95% CI, 1.33–1.73; P < .001) and lymph node metastasis (odd ratio = 2.96, 95% CI, 2.26–3.86; P < .001). Consistently, our bioinformatics analysis showed that increased securin expression was associated with worse OS and shorter disease-free survival in cancer patients.

Conclusion:
Our study indicated that securin overexpression was positively associated with metastasis and inversely related to the prognosis of patients with solid cancers. However, additional high-quality studies should be conducted to validate these findings.
Apatinib and temozolomide in children with recurrent ependymoma: A case report
Authors: Zhao Shuangshuang , Shen Zhipeng , Li Juan , Shi Lei , Zhang Ni 
Published: September 2022

Rationale:
Outcomes remain poor in children with recurrent ependyomams (rEPNs), despite advances in surgery and radiotherapy. Systemic therapeutic options are limited, given the low response to chemotherapy and targeted drugs. There is an urgent need for efective pharmacotherapy. Apatinib is a multitarget tyrosine kinase inhibitor, which has been reported to exhibit broad antitumor profiles. However, its effects on rEPNs have not been reported thus far.

Patient concerns:
We present a 5-year-old recurrent ependyomam patient benefting from apatinib and temozolomide. The patient was diagnosed with ependyomam in January 2016 and treated with surgery and radiotherapy. After surgery, the patient walked with an mild unsteady gait. He was diagnosed with recurrence in November 2018 following which he was treated with reoperation, reirradiation and chemotherapy (etopside, cisplatin, and temozolomide [TMZ]). The patients increased gait instability in April 2019.

Diagnoses:
Magnetic resonance imaging (MRI) showed progression of the disease. The lession at the left edge of the fourth ventricle and cerebellar peduncles was significantly increased.

Interventions:
The patient was administer TMZ (200 mg/m2/d, d1-5, 28 days as a cycle) + apatinib (250 mg, every other day). Twelve cycle of TMZ and apatinib were given.

Outcomes:
The tumor significantly shrank during the patient received TMZ and apatinib. After 9 months of medication, MRI revealed a nearly complete response However, the tumor progressed on May 5, 2020. From the beginning of the application of TMZ and apatinib, the progression-free survival was 1 year and the survival time was 19 months. Grade 1 leukocytopenia was observed without other adverse effects.

Conclusion:
Apatinib and temozolomide treatment with mild side effects may be a new option for children with recurrent ependyomams.
Effect of two combinations of low-dose oral contraceptives on adolescent bone mass: A clinical trial with 2 years follow-up
Authors: Caldeirão Talita Domingues , Orsolini Lilian Rodrigues , da Silva Carla Cristiane , Bisi Rizzo Anapaula da Conceição , Teixeira Altamir Santos , Nunes Hélio Rubens de Carvalho , Goldberg Tamara Beres Lederer 
Published: September 2022

Introduction:
Most contraceptive combinations can interfere with the processes of bone formation and resorption.

Aim:
The aim of this study was to evaluate the effect of 2 combinations of low-dose oral hormonal contraceptives (20 µg ethinyl estradiol [EE]/150 mg desogestrel [COC1] or 30 µg EE/3 mg drospirenone [COC2]) on bone mass acquisition in adolescents over 2 years by means of bone densitometry and measurement of biomarkers of bone remodeling.

Methods:
Parallel-group, non-randomized controlled clinical trial of 127 adolescents divided into a control group and 2 groups receiving either COC1 or COC2. The participants were submitted to anthropometric assessment and evaluation of secondary sexual characteristics (Tanner criteria) and bone age. Bone densitometry by dual-energy X-ray absorptiometry and measurement of bone biomarkers (bone alkaline phosphatase, osteocalcin, and C-terminal telopeptide) were performed at baseline and after 24 months.

Results:
No significant differences in the variables analyzed were observed between COC1 or COC2 users and the control group at baseline. After 24 months, non-users had incorporated more bone mass (content and density) than either group of contraceptive users. This negative impact was more pronounced in the COC2 group than in the COC1 group. A significant reduction in the percentage values of bone alkaline phosphatase and osteocalcin was observed in users of oral contraceptives.

Conclusion:
Bone mass acquisition was compromised in adolescent users of combined hormonal contraceptives. The negative impact was more pronounced in adolescents using contraceptives that contain 30 µg EE/3 mg drospirenone.
Precise quantitative evaluation of pharmacokinetics of cisplatin using a radio-platinum tracer in tumor-bearing mice
Authors: Obata Honoka , Tsuji Atsushi B. , Sudo Hitomi , Sugyo Aya , Minegishi Katsuyuki , Nagatsu Kotaro , Ogawa Mikako , Zhang Ming-Rong 
Published: September 2022

Objective
The platinum-based antineoplastic drug cisplatin is commonly used for chemotherapy in clinics. This work aims to demonstrate a radio-platinum tracer is useful for precisely quantifying small amounts of platinum in pharmacokinetics studies.

Methods
A cisplatin radiotracer (radio-cisplatin) was synthesized, and a comprehensive evaluation of cisplatin over 7 days after its intravenous injection into nude mice bearing a subcutaneous lung tumor (H460) was conducted.

Results
A biphasic retention curve in the whole body and blood was observed [T
1/2(α) = 1.14 h, T
1/2(β) = 5.33 days for the whole body, and T
1/2(α) = 23.9 min, T
1/2(β) = 4.72 days for blood]. The blood concentration decreased within 1 day after injection. Most of the intact cisplatin was excreted via the kidneys in the early time points, and a small part was distributed in tissues including tumors. The plasma protein binding rate of cisplatin increased rapidly after injection, and the protein-bound cisplatin remained in the blood longer than intact cisplatin. The peak uptake in H460 tumors was 4.7% injected dose per gram at 15 min after injection, and the area under the curve (AUC0–7 days) was approximately one-half to one-third of the AUC0–7 days in the kidneys, liver, and bone, where some toxicity is observed in humans.

Conclusion
The radio-platinum tracer revealed the highly quantitative biodistribution of cisplatin, providing insights into the properties of cisplatin, including its adverse effects. The tracer enables a precise evaluation of pharmacokinetics for platinum-based drugs with high sensitivity.
Metastasectomy in renal cell carcinoma: where are we now?
Authors: Lloyd Alexander , Reeves Fairleigh , Abu-Ghanem Yasmin , Challacombe Ben 
Published: September 2022

Purpose of review
Metastatic RCC has a variable natural history. Treatment choice depends on disease and patient factors, but most importantly disease burden and site of metastasis. This article highlights key variables to consider when contemplating metastasectomy for RCC and provide a narrative review on the evidence for metastasectomy in these patients.

Recent findings
Tumour subtype is associated with differing patterns of recurrence. Patients with single or few metastatic sites have better outcomes, and those with greater time interval from initial nephrectomy. Local recurrence is particularly amenable to minimally invasive surgical resection and is oncologically sound. Very well selected cases of liver or brain metastases may benefit from metastectomy, although lung and endocrine metastases have more favourable outcomes. Although site and burden of disease is important, the key determinate of outcome in metastasectomy depends mostly on the ability to achieve a complete resection. Adjuvant treatment is not currently advocated.

Summary
Metastasectomy should be generally reserved for cases where complete resection is achievable, unless the goal of treatment is to palliate symptoms. This field warrants ongoing research, particularly as systemic therapy and minimally invasive surgical techniques evolve. Elucidating tumour biology to inform patient selection will be important in future research.
Achieving Reductions in Opioid Dispensing: A Qualitative Comparative Analysis of State-Level Efforts to Improve Prescribing
Authors: Underwood Natasha L. , Kane Heather , Cance Jessica , Emery Kyle , Elek Elvira , Zule William , Rooks-Peck Cherie , Sargent Wesley , Mells Jamie 
Published: September 2022

Objective:
To determine whether any combinations of state-level public health activities were necessary or sufficient to reduce prescription opioid dispensing.

Design:
We examined 2016-2019 annual progress reports, 2014-2019 national opioid dispensing data (IQVIA), and interview data from states to categorize activities. We used crisp-set Qualitative Comparative Analysis to determine which program activities, individually or in combination, were necessary or sufficient for a better than average decrease in morphine milligram equivalent (MME) per capita.

Setting:
Twenty-nine US state health departments.

Participants:
State health departments implementing the Centers for Disease Control and Prevention's Prevention for States (PfS) program.

Main Outcome:
Combinations of prevention activities related to changes in the rate of prescription opioid MME per capita dispensing from 2014 to 2019.

Results:
Three combinations were sufficient for greater than average state-level reductions in MME per capita: (1) expanding and improving proactive reporting in combination with enhancing the uptake of evidence-based opioid prescribing guidelines and not moving toward a real-time Prescription Drug Monitoring Program; (2) implementing or improving prescribing interventions for insurers, health systems, or pharmacy benefit managers in combination with enhancing the uptake of evidence-based opioid prescribing guidelines; and (3) not implementing or improving prescribing interventions for insurers, health systems, or pharmacy benefit managers in combination with not enhancing the uptake of evidence-based opioid prescribing guidelines. Interview data suggested that the 3 combinations indicate how state contexts and history with addressing opioid overdose shaped programming and the ability to reduce MME per capita.

Conclusions:
States successful in reducing opioid dispensing selected activities that built upon existing policies and interventions, which may indicate thoughtful use of resources. To maximize impact in addressing the opioid overdose epidemic, states and agencies may benefit from building on existing policies and interventions.
“Regional-controlled tissue expanders increase skin expansion and thickness compared to standard tissue expanders in a rat model”
Authors: Xiong Zhezhen , Chen Yahong , Xu Peng , Chen Chuhsin , Xie Yun , Chang Yu , Pan Tingrui , Liu Kai 
Published: September 2022

Background:
Skin and soft tissue expansion are widely used. However, it cannot expand targeted areas on the top flap. Thus, we developed a new expander with a partially thickened top. We hypothesized that pressure differences would lead to higher growth near non-thickened regions and lower growth near thickened regions, allowing targeted expansion.

Methods:
Eighteen Sprague Dawley rats (8 weeks old, male) were used; 20-ml rectangular regional-controlled expanders (n=12) and ordinary expanders (n=6) were implanted. Flaps on regional-controlled expanders were divided into non-thickened (RCE-nt) and thickened (RCE-t) regions and tattooed. Discontinuous inflation began 14 days post-operation, 3 ml every 3 days, until the volume reached 50 ml. Tattooed skin area and thickness were measured. Immunofluorescence staining detected cell proliferation (PCNA+) and vascular density (CD31+). Growth factors (TGF-β, EGF, VEGF, and bFGF) were assessed by ELISA.

Results:
The expanded skin area of RCE-nt (396.2±41.4 mm2) was 33.8%±10.0% larger than that of RCE-t (297.8±38.9 mm2). RCE-t had a 28.9%±14.6% thicker dermal layer (942.4±55.5 µm) than RCE-nt (737.1±64.5 µm). RCE-nt had 295.0%±145.0% more PCNA(+) cells (92.4±16.2/mm2) than RCE-t (25.6±7.4/mm2). The vascular density was 133.0%±61.7% higher in RCE-t (24.8±4.7/mm2) than in RCE-nt (11.1±2.7/mm2)(all above p<0.05).

Conclusions:
Regional-controlled expansion specifically expands only the targeted area, causing thicker skin flaps with abundant vessels for defect repair. Although this technique has great clinical potential, it should be further validated with large animals and humans.
Sequential Behavioral Analysis: A Novel Approach to Help Understand Clinical Decision-Making Patterns in Extended Reality Simulated Scenarios
Authors: Rochlen Lauryn R. , Putnam Elizabeth M. , Tait Alan R. , Du Hanxiang , Popov Vitaliy 
Published: September 2022

Summary Statement
Extended reality (XR)-based simulation training offers unique features that facilitate collection of dynamic behavioral data and increased immersion/realism while providing opportunities for training health care professionals on critical events that are difficult to recreate in real life. Sequential analysis can be used to summarize learning behaviors by discovering hidden learning patterns in terms of common learning or clinical decision-making sequences. This project describes the use of sequential analysis to examine differential patterns of clinical decision-making behaviors in observed XR scenarios, allowing for new insights when using XR as a method to train for critical events and to trace clinical decision making.
Short Report: Race and Ethnicity Misclassification in Kidney Transplantation Research
Authors: Kernodle Amber B. , Thompson Valerie , Chen Xiaomeng , Norman Silas P. , Segev Dorry L. , Purnell Tanjala S. , McAdams-DeMarco Mara 
Published: September 2022

Background.
Recently, the misuse of race as a biological variable, rather than a social construct, in biomedical research has received national attention for its contributions to medical bias. In national transplant registry data, bias may arise from measurement imprecision because of the collection of provider-perceived race rather than patients’ own self-report.

Methods.
We linked Scientific Registry of Transplant Recipients data to a prospective, multicenter cohort study of adult kidney transplant patients (December 2008–February 2020) that collects patient-reported race. We computed Cohen’s kappa statistic to estimate agreement between provider-perceived and patient-reported race in the 2 data sources. We used an unadjusted generalized linear model to examine changes in agreement over time.

Results.
Among 2942 kidney transplant patients, there was almost perfect agreement among Asian (kappa = 0.88, 95% confidence interval [CI], 0.84-0.92), Black (kappa = 0.97, 95% CI, 0.96-0.98), and White categories (kappa = 0.95, 95% CI, 0.93-0.96) and worse agreement among Hispanic/Latino (kappa = 0.66, 95% CI, 0.57-0.74) and Native Hawaiian/Other Pacific Islander categories (kappa = 0.40, 95% CI, 0.01-0.78). The percent agreement decreased over time (difference in percent agreement = –0.55, 95% CI, –0.75 to –0.34). However, there were differences in these trends by race: –0.07/y, 95% CI, –0.21 to 0.07 for Asian; –0.06/y, 95% CI, –0.28 to 0.16 for Black; –0.01/y, 95% CI, –0.21 to 0.19 for Hispanic/Latino; –0.43/y, 95% CI, –0.58 to –0.28 for White categories.

Conclusions.
Race misclassification has likely led to increasingly biased research estimates over time, especially for Asian, Hispanic/Latino, and Native Hawaiian/Other Pacific Islander study populations. Improvements to race measurement include mandating patient-reported race, expanding race categories to better reflect contemporary US demographics, and allowing write-ins on data collection forms, as well as supplementing data with qualitative interviews or validated measures of cultural identity, ancestry, and discrimination.
Calibration of Agent Based Models for Monophasic and Biphasic Tumour Growth using Approximate Bayesian Computation
Authors: Wang Xiaoyu , Jenner Adrianne L. , Salomone Robert , Warne David J. , Drovandi Christopher 
Published: September 2022

AbstractAgent-based models (ABMs) are readily used to capture the stochasticity in tumour evolution; however, these models are often challenging to validate with experimental measurements due to model complexity. The Voronoi cell-based model (VCBM) is an off-lattice agent-based model that captures individual cell shapes using a Voronoi tessellation and mimics the evolution of cancer cell proliferation and movement. Evidence suggests tumours can exhibit biphasic growthin vivo. To account for this phenomena, we extend the VCBM to capture the existence of two distinct growth phases. Prior work primarily focused on point estimation for the parameters without consideration of estimating uncertainty. In this paper, approximate Bayesian computation is employed to calibrate the model toin vivomeasurements of breast, ovarian and pancreatic cancer. Our approach involves estimating the distribution of parameters that govern cancer cell proliferation and recovering outputs that match the experimental data. Our results show that the VCBM, and its biphasic extension, provides insight into tumour growth and quantifies uncertainty in the switching time between the two phases of the biphasic growth model. We find this approach enables precise estimates for the time taken for a daughter cell to become a mature cell. This allows us to propose future refinements to the model to improve accuracy, whilst also making conclusions about the differences in cancer cell characteristics.
The clustering of spatially associated species unravels patterns in Bornean tree species distributions
Authors: Pang Sean E. H. , Ferry Slik J. W. , Zurell Damaris , Webb Edward L. 
Published: September 2022

AbstractComplex distribution data can be summarised by grouping species with similar or overlapping distributions to unravel patterns in species distributions and separate trends (e.g., of habitat loss) among spatially unique groups. However, such classifications are often heuristic, lacking the transparency, objectivity, and data-driven rigour of quantitative methods, which limits their interpretability and utility. Here, we develop and illustrate the clustering of spatially associated species, a methodological framework aimed at statistically classifying species using explicit measures of interspecific spatial association. We investigate several association indices and clustering algorithms and show how these methodological choices engender substantial variations in clustering outcome and performance. To facilitate robust decision making, we provide guidance on choosing methods appropriate to the study objective(s). As a case study, we apply the framework to model tree distributions in Borneo to evaluate the impact of land-cover change on separate species groupings. We identified 11 distinct clusters that unravelled ecologically meaningful patterns in Bornean tree distributions. These clusters then enabled us to quantify trends of habitat loss tied to each of those specific clusters, allowing us to discern particularly vulnerable species clusters and their distributions. This study demonstrates the advantages of adopting quantitatively derived clusters of spatially associated species and elucidates the potential of resultant clusters as a spatially explicit framework for investigating distribution-related questions in ecology, biogeography, and conservation. By adopting our methodological framework and publicly available codes, practitioners can leverage the ever-growing abundance of distribution data to better understand complex spatial patterns among species distributions and the disparate effects of global changes on biodiversity.Statement of authorshipSEHP and ELW conceived the idea and designed methodology. SEHP conducted all analyses and developed the methodological framework with key inputs from ELW, JWFS, and DZ. All authors contributed to the interpretation of the results. SEHP and ELW wrote the first draft of the manuscript. All authors provided feedback on the writing.