bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening of ferroptosis-related genes in sepsis-induced liver failure and analysis of immune correlation
Authors: Chen Qingli , Liu Luxiang , Ni Shuangling 
Published: July 2022

Purpose
Sepsis-induced liver failure is a kind of liver injury with a high mortality, and ferroptosis plays a key role in this disease. Our research aims to screen ferroptosis-related genes in sepsis-induced liver failure as targeted therapy for patients with liver failure.

Methods
Using the limma software, we analyzed the differentially expressed genes (DEGs) in the GSE60088 dataset downloaded from the Gene Expression Omnibus (GEO) database. Clusterprofiler was applied for enrichment analysis of DEGs enrichment function. Then, the ferroptosis-related genes of the mice in the FerrDb database were crossed with DEGs. Sepsis mice model were prepared by cecal ligation and perforation (CLP). ALT and AST in the serum of mice were measured using detection kit. The pathological changes of the liver tissues in mice were observed by hematoxylin-eosin (H & E) staining. We detected the apoptosis of mice liver tissues using TUNEL. The expression of Hmox1, Epas1, Sirt1, Slc3a2, Jun, Plin2 and Zfp36 were detected by qRT-PCR.

Results
DEGs analysis showed 136 up-regulated and 45 down-regulated DEGs. Meanwhile, we found that the up-regulated DEGs were enriched in pathways including the cytokine biosynthesis process while the down-regulated DEGs were enriched in pathways such as organic hydroxy compound metabolic process. In this study, seven genes (Hmox1, Epas1, Sirt1, Slc3a2, Jun, Plin2 and Zfp36) were obtained through the intersection of FerrDb database and DEGs. However, immune infiltration analysis revealed that ferroptosis-related genes may promote the development of liver failure through B cells and natural killer (NK) cells. Finally, it was confirmed by the construction of septic liver failure mice model that ferroptosis-related genes of Hmox1, Slc3a2, Jun and Zfp36 were significantly correlated with liver failure and were highly expressed.

Conclusion
The identification of ferroptosis-related genes Hmox1, Slc3a2, Jun and Zfp36 in the present study contribute to our understanding of the molecular mechanism of sepsis-induced liver failure, and provide candidate targets for the diagnosis and treatment of the disease.
Damascus Covenant
, the (Dead Sea Scrolls)
Authors: Dimant Devorah 
Published: July 2022

Abstract

The
Damascus Covenant
, a text known from both the Cairo Genizah and the Dead Sea Scrolls, describes the covenant concluded by the Qumran community during a sojourn in Damascus. The work was probably assembled in the late second or early first century
bce
although some components may have been composed earlier.
Army, Late Antiquity
Authors: Whately Conor 
Published: July 2022

AbstractIn 235 ce, at the beginning of Late Antiquity, though the Roman army had changed from the army of 14 ceat the end of the reign of Augustus, it was still broadly similar. By the seventh century, and in the aftermath of the Arab invasion of the Near East, the transformation of the Roman army had been completed, with significant differences with regard to its organization, size, tactics, strategy, and operations. What had been a heavily armed force, which sought to engage its foes head‐on and whose primary strength lay in its infantry, had become a force that often sought to avoid pitched battle unless left with no alternative, and whose strength lay in its cavalry.
Artisans, trades, and guilds, Late Antiquity
Authors: Gibbs Matt 
Published: July 2022

Abstract
Continuing an earlier practice, artisans from a variety of crafts and trades came together – perhaps under compulsion – to form associations, or more commonly, guilds. These associations offered advantages not only to their members, but also to the state in respect to the collection of taxes, the control and use of labor, and the supply of food and services.
Kallippos (Callippus) of Eleusis
Authors: Sakeshima Kyohei 
Published: July 2022

AbstractKallippos, son of Moirokles, of Eleusis was an Athenian general and diplomat who flourished in the 270s and 260sbce. He is best known for commanding the Athenian force at Thermopylai against the Gauls in 279bce.
Causes of Death Among Individuals With Systemic Lupus Erythematosus by Race and Ethnicity: A Population‐Based Study
Authors: Taylor Tiffany , Anastasiou Christine , Ja Clairissa , Rush Stephanie , Trupin Laura , Dall'Era Maria , Katz Patricia , Barbour Kamil E. , Greenlund Kurt J. , Yazdany Jinoos , Gianfrancesco Milena A. 
Published: July 2022

ObjectiveNon‐White populations are at higher risk of developing systemic lupus erythematosus (SLE) and have more severe outcomes, including mortality. The present study was undertaken to examine how specific causes of death vary by race and ethnicity, including Asian and Hispanic individuals.MethodsThe California Lupus Surveillance Project included SLE cases identified among residents of San Francisco County, CA during January 1, 2007 to December 31, 2009. Cases were matched to the National Death Index over a 10‐year period. Logistic regression examined age‐adjusted differences in causes of death by race, ethnicity, and sex. Age‐standardized mortality ratios between individuals with SLE and the corresponding general population were calculated for the leading cause of death, and observed versus expected deaths were estimated.ResultsThe study included 812 individuals of White (38%), Asian (36%), Black (20%), and mixed/other/unknown (5%) race; 15% identified as Hispanic. One hundred thirty‐five deaths were recorded, with a mean ± SD age at death of 62.2 ± 15.6 years. Cardiovascular disease (CVD) was the leading cause of death overall (33%), and across all racial and ethnic groups, followed by rheumatic disease (18%) and hematologic/oncologic conditions (18%). CVD as the underlying cause of death was 3.63 times higher among SLE cases than in the general population. CVD deaths for those with SLE were nearly 4 and 6 times higher for Asian and Hispanic individuals with SLE, respectively, compared to the general population.ConclusionIndividuals with SLE experience a disproportionate burden of CVD mortality compared to the general population, which is magnified for Asian and Hispanic groups.
Charge Extraction in Flexible Perovskite Solar Cell Architectures for Indoor Applications – with up to 31% Efficiency
Authors: Teixeira Cristina , Spinelli Pierpaolo , Castriotta Luigi Angelo , Müller David , Öz Senol , Andrade Luísa , Mendes Adélio , Carlo Aldo Di , Würfel Uli , Wojciechowski Konrad , Forgács Dávid 
Published: July 2022

AbstractPerovskite Solar Cells (PSCs) are well known for their high efficiencies under 1 sun (AM1.5G), however, PSC can also generate power by harvesting the low‐light available indoors. Here, three flexible PSC architectures are presented for indoor applications: with a metal electrode aiming for high efficiency; carbon electrode aiming for high stability and compatibility with large‐scale production; and hole transport material (HTM)‐free carbon for simplifying the fabrication process. A maximum efficiency of 30.9% (30.0%) under 1000 lux (200 lux) is obtained for a PSC with gold electrode. A maximum efficiency of 25.4% (24.7%) and 23.1% (22.3%) is obtained for the carbon devices with and without HTM, respectively, under 1000 lux (200 lux). To the best of the author's knowledge, the efficiency values presented here for a device with a carbon‐based electrode, with and without HTM, are the record values for a flexible PSC at indoor light conditions. Furthermore, the HTM‐free carbon device kept 84% of its initial efficiency after 1000 h at MPPT and lost virtually no performance after 1000 h at 85 °C. Also, non‐encapsulated devices of all configurations withstood 1600 h in air with a maximum loss in efficiency of 6%.
In Situ Growth of Covalent Organic Framework Nanosheets on Graphene as the Cathode for Long‐Life High‐Capacity Lithium‐Ion Batteries
Authors: Liu Xiaolin , Jin Yucheng , Wang Hailong , Yang Xiya , Zhang Pianpian , Wang Kang , Jiang Jianzhuang 
Published: July 2022

AbstractThe poor electronic and ionic conductivities of covalent organic frameworks (COFs) severely restrict the development of COF‐based electrodes for practical rechargeable batteries, therefore inspiring more research interest from the direction of both material synthesis and technology. Herein, a dual‐porous COF, USTB‐6, with good crystallinity and rich redox‐active sites is conceived and fabricated by the polymerization of 2,3,8,9,14,15‐hexa(4‐formylphenyl)diquinoxalino [2,3‐a:2′,3′‐c]phenazine and 2,7‐diaminopyrene‐4,5,9,10‐tetraone. In particular, the heterogeneous polymerization of the same starting materials in the presence of graphene affords uniformly dispersed COF nanosheets with a thickness of 8.3 nm on a conductive carbon substrate, effectively enhancing the electronic conductivity of the COF‐based electrode. Such a graphene‐supported USTB‐6 nanosheets cathode when used in a lithium‐ion battery exhibits a specific capacity of 285 mA h g−1 at a current density of 0.2 C and excellent rate performance with a prominent capacity of 188 mA h g−1 at 10 C. More importantly, a capacity of 170 mA h g−1 is retained by using the USTB‐6 nanosheets cathode after 6000 cycles charge and discharge measurement at 5 C.
Orbital Shift‐Induced Boundary Obstructed Topological Materials with a Large Energy Gap
Authors: Mao Ning , Li Runhan , Dai Ying , Huang Baibiao , Yan Binghai , Niu Chengwang 
Published: July 2022

AbstractBoundary obstructed topological phases caused by Wannier orbital shift between ordinary atomic sites are proposed, which, however, cannot be indicated by symmetry eigenvalues at high symmetry momenta (symmetry indicators) in bulk. On the open boundary, Wannier charge centers can shift to different atoms from those in bulk, leading to in‐gap surface states, higher‐order hinge states or corner states. To demonstrate such orbital shift‐induced boundary obstructed topological insulators, eight material candidates are predicted, all of which are overlooked in the present topological databases. Metallic surface states, hinge states, or corner states cover the large bulk energy gap (e.g., more than 1 eV in TlGaTe2) at related boundary, which are ready for experimental detection. Additionally, these materials are also fragile topological insulators with hourglass‐like surface states.
Brittle PCDTPT Based Elastic Hybrid Networks for Transparent Stretchable Skin‐Like Electronics
Authors: Guo Shanlei , Tong Yanhong , Wang Xue , Zhang Mingxin , Yu Hongyan , Ren Hang , Tang Qingxin , Lu Guanghao , Liu Yichun 
Published: July 2022

AbstractOrganic semiconductors offer the opportunity to develop intrinsically stretchable skin‐like electronics for future applications. However, the lack of intrinsically stretchable materials is still a fundamental challenge, originating from the brittle nature of most organic semiconductors with the fracture strain at a few percent (<10%). Here, a stretchable semiconductor composite is reported by blending the brittle poly[4‐(4,4‐dihexadecyl‐4H‐cyclopenta[1,2‐b:5,4‐b′]dithiophen‐2‐yl)‐alt‐[1,2,5]thiad‐iazolo [3,4‐c] pyridine] (PCDTPT) semiconductor with the crack‐onset strain only at 5% and the styrene‐ethylene‐butylene‐styrene elastomer. This blend films present the increased crack‐onset strain up to 182% and superior optical transparency (>95% at 550 nm), with mobility as high as 2.31 cm2 V−1 s−1. The depth‐dependence light absorption spectra and the conductive atomic force microscopy images in horizontal and vertical directions of the blend film confirm the nonuniform distribution of PCDTPT fibers with sandwiched structure, which weakens the effect of device configuration on mobility. Compared with the conventional uniform film, the sandwiched film weakens the effect of device configuration on mobility. The fully transparent stretchable transistors with the blend films show the outstanding ductility and high optical transparency. This work opens up a feasible path for brittle organic semiconductors used in the transparent stretchable transistor, presenting their promising potential in future see‐through skin‐like electronics.
Favorable outcome of geriatric telemedicine for frail older adults with COVID‐19 staying at home during the omicron tsunami in Hong Kong
Authors: Kong Tak‐kwan 
Published: July 2022

AbstractHong Kong was hit by a tsunami of COVID‐19 in mid‐February 2022, impacting on frail older adults with high COVID‐19 mortality. Two older adults with COVID‐19 managed by geriatric telemedicine at home were reported with favorable outcome despite severe frailty (Clinical Frailty Score 7). Stressed by COVID‐19, both presented with the geriatric giants or frailty syndromes of brain failure (delirium) and balance failure (falls). Their successful outcome resulted not from COVID‐19 antiviral treatment, but individualized holistic person‐centered care attending to the frailty syndromes: optimized treatment of comorbid conditions by medication review, medication reduction on recognition of drug‐induced hypotension and hypoglycaemia, appropriate use of medication to reduce iatrogenesis, caregivers' replenishment of fluid and nutrition deficit, oxygen support during critical hypoxic period, and recognition and early treatment of superimposed infections (bacterial respiratory tract superinfection, herpes zoster). Their social support was good. Family members and helpers became invaluable resources in providing the much‐needed personal care, nutrition, hydration, comfort, and health monitoring to keep the geriatrician informed of their condition and to draw up an individualized management plan. Home environment and human presence were therapeutic in delirium care, avoiding damage from separation and isolation commonly practiced in this COVID‐19 pandemic.
SpeedMixing: Rapid Tribochemical Synthesis and Discovery of Pharmaceutical Cocrystals without Milling or Grinding Media**
Authors: Teoh Yong , Ayoub Ghada , Huskić Igor , Titi Hatem M. , Nickels Christopher W. , Herrmann Brad , Friščić Tomislav 
Published: July 2022

AbstractWe present SpeedMixing, a rapid blending technology, as an approach for fast mechanosynthesis and discovery of model pharmaceutical cocrystals through rapid spinning in the absence of bulk solvents and milling/grinding media. Syntheses of pharmaceutical cocrystals based on the active pharmaceutical ingredients (APIs) carbamazepine, dihydrocarbamazepine, and nicotinamide demonstrate SpeedMixing as a method for rapid, scalable, as well as controllable and selective synthesis of cocrystals, cocrystal polymorphs and stoichiomorphs, including the discovery of an unexpected methanol solvate of the archetypal cocrystal of carbamazepine and saccharin, which has eluded extensive screens over 20 years.
Agglomeration tendency and activated carbon concentration effects on activated carbon‐polysulfone mixed matrix membrane performance: A design of experiment formulation study
Authors: Lewis Jeremy , Alshami Ali , Talukder Musabbir , Owoade Ademola , Baker Kelsey , Onaizi Sagheer 
Published: July 2022

AbstractMixed matrix membranes (MMMs) are effective materials for emerging separation applications. While MMMs show promise, various membrane formation schemes have produced particle agglomerations, surface ruptures, and varying separation performance as a result. In this work, a replicated 2 × 23 full factorial design of experiment (DOE) and a mixture analysis was conducted to investigate the effects of activated carbon, polyethylene glycol (PEG), and solvent type, used during MMM formation. Aniline blue filtration was used as a model for performance. A thorough analysis was conducted on contact angle, agglomeration frequency, water flux, and dye rejection. Specifically, a novel and facile method to study agglomeration tendencies is presented. Among other trends, agglomeration tendencies were mitigated by the addition of PEG during the fabrication process. Water flux increased from 10 to 55 LMH when PEG was used as a pore former and dye rejection increased from 72% to 90% with the addition of AC particles.
Evaluation of nanofibril chitosan@8‐formyl‐7‐hydroxy‐coumarin hydrogel having distinct auto‐fluorescence efficiency: Structure–properties relation, improved antioxidant, and cellular imaging
Authors: Ghorai Shubhankar , Jana Biswajit , Pan Dipika , Ramasamy Thilagam , Parshi Nira , Arumugam Gnanamani , Ganguly Jhuma 
Published: July 2022

AbstractThe modification at the branching of chitosan using 8‐formyl‐7‐hydroxy‐coumarin (ChCm) through chemically cross‐linked has been structured for hydrogel fabrication. ChCm produced stable mechanical properties, improved swelling capacity, and delayed degradation for new cross linking‐functionalized during experimental works. It also imparted high antioxidant potency. The swelling water ratio of this hydrogel makes it robust and elastic, providing a mechanical basis to keep the hydrogel strong and steady. A remarkable self‐fluorescence behavior has been witnessed. The distinct photo‐sensitiveness has been studied thoroughly as time, temperature, and solvent‐dependent spectral analysis to establish the ESIPT mechanism and improve stability in various conditions. Detailed instrumental‐structural evaluations are explored as required, and optimized the gel skeleton and photo activities are using DFT calculations. The effectiveness of radical scavenging using DPPH, antioxidant power using FRAP assay, and chelation ability have been observed during the evaluation of antioxidant potency for hydrogel. The role of phenolic‐OH is very significant not only for optical fluorescence enhancement by ESIPT but also for the improved antioxidant abilities. As well as being less toxic, bio‐compatible, and photostable, it could be used to image fibroblast 3T3 cells by fluorescence; current hydrogel has gained vast potential for developing dynamic biomaterials in multiple applications.
The impact of cellulose nanocrystals on the rheology of sodium carboxymethyl cellulose and sodium alginate
Authors: Cui Shaoning , Cui Congli , Ge Shengju , Xie Wei , Yu Mengting , Li Ying , Sun Qingjie , Xiong Liu 
Published: July 2022

AbstractAt present, the physical properties of hydrocolloids limit their wide application in food industry. To improve the viscoelasticity of sodium carboxymethyl cellulose (CMC) and sodium alginate (SA), cellulose nanocrystals (CNCs) were added into CMC and SA solutions to regulate the non‐Newtonian flow behaviors of composite systems under different conditions. The rheological properties of CMC/CNCs or SA/CNCs composite systems were studied using steady rheological measurements, dynamic rheological measurements, and creep compliance experiments. It was found that the viscosities and elastic modulus of CMC were positively related to CNCs concentrations in acid, neutral or alkaline environments. When the CNCs content was higher than 5% at pH 9.45, the gelation of CMC was accelerated, and the gelation strength was increased. The damping factor of SA decreased with increasing calcium ions contents. When calcium ions content was higher than 0.07%, the damping factor of SA was less than 1, indicating that SA system achieved gel transformation. The effect of CNCs on the apparent viscosity, shear stress, and storage modulus of CMC was more obvious in comparison to that of SA. Overall, as a rheology modifier, CNCs can minimize the contents of food colloids in any functional fluid while maintaining the thickening rheology.
Thermomechanical and optical characteristics of nanoquartz‐ and nanozircon‐filled poly(methyl methacrylate) composites
Authors: Hilmi Allif Rosyidy , Purnamasari Novita Dwi , Wulandari Wiwit , Sari Anisa Indah , Fauziyah Nur Aini , Asrori M. Zainul , Pratapa Suminar 
Published: July 2022

AbstractThe thermomechanical and optical properties of poly(methyl methacrylate) (PMMA)/quartz and PMMA/zircon composites at filler content variations of 0, 1, 2.5, and 5 wt% have been studied. The silica quartz and zircon powders were derived from local sands collected from Tanah Laut, South Kalimantan, and Kereng Pangi, Central Kalimantan, Indonesia, respectively. The nanoquartz and nanozircon fillers (herewith were designated as quartz and zircon respectively) were obtained by milling these powders for 15 h. Dynamic mechanical analysis was used to acquire the storage modulus and glass transition temperature as the thermomechanical properties of the PMMA/quartz and PMMA/zircon composites. Meanwhile, the optical properties were determine using ultraviolet–visible spectroscopy. Results indicate that zircon fillers can improve the storage modulus of the composites up to 1.85 times that of PMMA alone. Zircon is more effective than silica in improving the storage modulus of PMMA. Implementing the degradation rate model shows us that all the composites have nearly the same degradation behavior in the glassy region. Moreover, the addition of fillers decreases the band gap energies.
Toward the cholinesterase inhibition potential of TADDOL derivatives: Seminal biological and computational studies
Authors: Costantino Andrea R. , Charbe Nitin , Duarte Yorley , Gutiérrez Margarita , Giordano Ady , Prasher Parteek , Dua Kamal , Mandolesi Sandra , Zacconi Flavia C. 
Published: July 2022

AbstractAlzheimer's disease (AD) is a degenerative neurological disease characterized by gradual loss of cognitive skills and memory. The exact pathogenesis involved still remains unrevealed, but several studies indicate the involvement of an array of different enzymes, underlining the multifactorial character of the disease. Inhibition of these enzymes is therefore a powerful approach in the development of AD treatments, with promising candidates, including acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and monoamine oxidase. Interestingly, AChE is the target of a major pesticide family (organophosphates), with several reports indicating an intersection between the pesticide's activity and AD. In this study, various TADDOL derivatives were synthesized and their in vitro activities as AChE/BuChE inhibitors as well as their antioxidant activities were studied. Molecular modeling studies revealed the capability of TADDOL derivatives to bind to AChE and induce inhibition, especially compounds 2b and 3c furnishing IC50 values of 36.78 ± 8.97 and 59.23 ± 5.31 µM, respectively. Experimental biological activities and molecular modeling studies clearly demonstrate that TADDOL derivatives with specific stereochemistry have an interesting potential for the design of potent AChE inhibitors. The encouraging results for compounds 2b and 3c indicate them as promising scaffolds for selective and potent AChE inhibitors.