Eating Disorders In weight-related Therapy (EDIT): Protocol for a systematic review with individual participant data meta-analysis of eating disorder risk in behavioural weight management
Authors: Jebeile Hiba , Lister Natalie B. , Libesman Sol , Hunter Kylie E. , McMaster Caitlin M. , Johnson Brittany J. , Baur Louise A. , Paxton Susan J. , Garnett Sarah P. , Ahern Amy L , Wilfley Denise E. , Maguire Sarah , Sainsbury Amanda , Steinbeck Katharine , Askie Lisa , Braet Caroline , Hill Andrew J , Nicholls Dasha , Jones Rebecca A , Dammery Genevieve , Grunseit Alicia M. , Cooper Kelly , Kyle Theodore K. , Newsome Faith , Quigley Fiona , Barnes Rachel D. , Bean Melanie K. , Beaulieu Kristine , Bonham Maxine , Boutelle Kerri N. , Branco Braulio Henrique Magnani , Calugi Simona , Cardel Michelle I. , Carpenter Kelly , Cheng Hoi Lun , Grave Riccardo Dalle , Danielsen Yngvild S , Demarzo Marcelo , Dordevic Aimee , Eichen Dawn M. , Goldschmidt Andrea B. , Hilbert Anja , Houben Katrijn , Lofrano do Prado Mara , Martin Corby K. , McTiernan Anne , Mensinger Janell L. , Pacanowski Carly , do Prado Wagner Luiz , Ramalho Sofia M. , Raynor Hollie A. , Rieger Elizabeth , Robinson Eric , Salvo Vera , Sherwood Nancy E. , Simpson Sharon A. , Skjakodegard Hanna F. , Smith Evelyn , Partridge Stephanie , Tanofsky-Kraff Marian , Taylor Rachael W. , Van Eyck Annelies , Varady Krista A. , Vidmar Alaina P. , Whitelock Victoria , Yanovski Jack , Seidler Anna L. 
Published: December 2022

ABSTRACTThe Eating Disorders In weight-related Therapy (EDIT) Collaboration brings together data from randomised controlled trials of behavioural weight management interventions to identify individual participant risk factors and intervention strategies that contribute to eating disorder risk. We present a protocol for a systematic review and individual participant data (IPD) meta-analysis which aims to identify participants at risk of developing eating disorders, or related symptoms, during or after weight management interventions conducted in adolescents or adults with overweight or obesity. We systematically searched four databases up to March 2022 and clinical trials registries to May 2022 to identify randomised controlled trials of weight management interventions conducted in adolescents or adults with overweight or obesity that measured eating disorder risk at pre- and post-intervention or follow-up. Authors from eligible trials have been invited to share their deidentified IPD. Two IPD meta-analyses will be conducted. The first IPD meta-analysis aims to examine participant level factors associated with a change in eating disorder scores during and following a weight management intervention. To do this we will examine baseline variables that predict change in eating disorder risk within intervention arms. The second IPD meta-analysis aims to assess whether there are participant level factors that predict whether participation in an intervention is more or less likely than no intervention to lead to a change in eating disorder risk. To do this, we will examine if there are differences in predictors of eating disorder risk between intervention and no-treatment control arms. The primary outcome will be a standardised mean difference in global eating disorder score from baseline to immediately post-intervention and at 6- and 12-months follow-up. Identifying participant level risk factors predicting eating disorder risk will inform screening and monitoring protocols to allow early identification and intervention for those at risk.