bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of stress and depression and associated factors among women seeking a first-trimester induced abortion in China: A cross-sectional study
Authors: Zhang Qiuxiang , Wang Na , Hu Yanchu , Creedy Debra K. 
Published: January 2022

Abstract
Objectives
To determine the prevalence of stress and depression and associated factors among women seeking a first-trimester induced abortion in China.
Methods
A cross-sectional study was conducted in a tertiary hospital in Beijing, from April 1st to Oct 31st, 2021. Women seeking termination of an intrauterine first-trimester pregnancy were invited to participate and complete a digital self-administered questionnaire. The survey included socio-demographic and health questions, Perceived Stress Scale-10 (PSS-10), and Patient Health Questionnaire-9 (PHQ-9). Descriptive analyses and binary logistic regression analyses were performed using SPSS 23.0.
Results
A total of 253 women participated. Prevalence of high perceived stress (cut-off≥20) and depressive symptoms (cut-off ≥ 10) was 25.3% and 22.5% respectively. Women were more likely to suffer high stress if they reported low resilience (aOR = 16.84, 95% CI 5.18-54.79), were not-using contraceptives (aOR = 3.27, 95% CI 1.39-6.29), had low social support (aOR = 2.95, 95% CI 1.39-6.29), were non-local residents (aOR = 2.51, 95% CI 1.15-5.92), were dissatisfied with their intimate relationship (aOR = 2.44, 95% CI 1.15-5.16), or held pro-life attitudes towards abortion (aOR = 1.04, 95% CI 1.18-3.53). Odds of experiencing depression were higher among women who also reported high perceived stress (aOR = 19.00, 95% CI 7.67-47.09), had completed higher education (aOR = 12.28, 95% CI 1.24-121.20), and were non-local residents (aOR = 3.38, 95% CI 1.37-8.32).
Conclusions
The magnitude of perceived stress and depression was high among Chinese women seeking a first-trimester induced abortion. It is necessary to comprehensively evaluate the mental health of all women seeking an abortion. Interventions to mitigate relevant associated factors could improve the psychological wellbeing of women.
Offset nail fixation for intertrochanteric fractures improves reduction and lag screw position
Authors: Tanaka Sakae , Matsubara Takehiro , Soma Kazuhito , Yamada Ikufumi , Fujita Hiroshi , Yoshitani Junya , Oka Hiroyuki 
Published: January 2022

Abstract
Background: Surgery for intertrochanteric fractures using intramedullary hip nails (IHNs) is one of the most common surgeries in the orthopedic field. Although IHNs provide a good overall outcome, they sometimes cause complications (e.g. a loss of reduction and cut-out). We compared the usefulness of IHNs with an anterior offset (Best Fit Nail® [BFN]) in maintaining the reduction of fragments and ensuring proper lag screw positioning to that with conventional non-offset nails, using postoperative computed tomography (CT). Methods: Fifty consecutive patients with intertrochanteric fractures who underwent surgery with BFNs (BFN group) and 50 patients who underwent surgery with conventional non-offset nails (control group) were retrospectively analyzed. Indices evaluated by postoperative CT comprised the displacement distance of proximal fragments relative to distal fragments, reduction status (intramedullary, anatomical, and extramedullary types), screw direction, and the angle between the screw and the femoral neck axis (deviation angle).Results: The median displacement distance [interquartile range] was significantly smaller in the BFN group (0 [0, 0] mm) and in the control group (4.4 [3.1, 6.3] mm) (p<0.0001). Additionally, the reduction status was significantly better in the BFN group (anatomical type in 40 cases, intramedullary type in 9 cases, and extramedullary type in 1 case) than in the control group (anatomical type in 6 cases, intramedullary type in 40 cases, and extramedullary type in 4 cases) (p<0.0001). Deviation of the lag screw direction was observed in significantly fewer cases in the BFN group (20 cases; 40%) than in the control group (35 cases; 70%). The deviation angle of the lag screw was significantly smaller in the BFN group (-0.71°±4.0°) than in the control group (5.7°±5.3°). No adverse events related to surgery were observed in either group.Conclusions: Intertrochanteric fracture surgeries using BFNs exhibited significantly smaller displacement distance, better reduction status, and higher frequency of no deviation, with central lag screw positioning, compared to those using conventional non-offset nails.
How Vertical Global Health Programs Can Contribute to Universal Health Coverage: Service Delivery Implementation Lessons from Polio Eradication
Authors: Olateju Adetoun , Peters Michael , Osaghae Ikponmwosa , Alonge Olakunle 
Published: January 2022

Abstract
Background

Improving service delivery is a key strategy for achieving service coverage, one of the two components of universal health coverage (UHC). As one of the largest global public health initiatives, individuals involved with the Global Polio Eradication Initiative (GPEI) have learned many important lessons about service delivery. We identified contributors and challenges to delivering health services at national and subnational levels using experiences from the GPEI. We described strategies used to strengthen service delivery and draw lessons that could be applicable to achieving UHC.
Methods

Online cross-sectional surveys based on the Consolidated Framework for Implementation Research (CFIR) domains were conducted from 2018-2019. Data were analyzed using an embedded mixed methods approach. Frequencies of the contributors and challenges to service delivery by levels of involvement were estimated. Chi-square tests of independence were used to assess unadjusted associations among categorical outcome variables. Logistic regressions were used to examine the association between respondent characteristics and contributors to successful implementation or implementation challenges. Horizontal analysis of free text responses by CFIR domain was done to contextualize the quantitative results.
Results

Among the 3,659 survey respondents, 887 (24.2%) reported involvement in strengthening service delivery at the global, national, or subnational level with more than 90% involved at subnational levels. The most important internal contributor to strengthening service delivery was the process of conducting activities (48%), e.g., microplanning, and strategies to reach high-conflict or remote populations. The highest external contributor was the social environment (42.5%), e.g., community awareness and trust in health workers. Respondents working at national and subnational levels had four times significantly higher odds (adjusted odds ratio = 4.26, p=0.007) of identifying the external environment e.g., insecurity and community resistance, as the biggest challenge to service delivery, compared to those in advisory roles. Strategies for mitigating community resistance included use of indigenous community volunteers, social mobilization networks.
Conclusion

Prioritizing these contributors and adopting subnational strategies from polio eradication programs to address broader service delivery challenges could improve implementation of integrated, essential primary healthcare services to bolster service delivery and accelerate progress. Achieving UHC is contingent on strengthened subnational service delivery.
Temporal and Spatial Variability in Metabolism of the Antarctic Pelagic Tunicate Salpa Thompsoni Foxton, 1961
Authors: Minkina Natalia Iosiphovna , Samyshev Ernest Zainullinovich , Pakhomov Evgeny , Melnikov Victor Vladimirovich 
Published: January 2022

Abstract
The weight-specific metabolic rates of the Antarctic pelagic tunicate Salpa thompsoni Foxton, 1961 were studied during March-April of 1998 and March 2002. The study revealed large variability in metabolic rates and attempted to explain the observed variability. The main factors driving variability, which were previously overlooked, included density of tunicates in incubation containers (incubation density), diel/circadian rhythms in salp ecophysiology, and spatial variability of their metabolic performance. The salp-specific respiration rates at 3°C were strongly negatively influenced by their incubation density ranging between 2.0 and 90.4 gWW·l−1. The metabolism of both salp life forms (solitaries and aggregates) appeared to be independent of their body mass. At incubation densities of 3 gWW·l−1, salps solitary and aggregate forms showed similar circadian rhythms in the respiration rates, with mean daytime and nighttime respiration rates of 79.5 and 41.5 µg O2·gWW−1·h−1 or 26.0% and 13.6% of the body carbon content, respectively. These specific respiration rates of S. thompsoni were assumed to be a "statistical norm" or climatology and were compared to actual field point observations during 1998 and 2002 near the Elephant Island, the South Orkney Islands, and the Bransfield Strait allowing calculating deviations from the "norm". This identified areas of the salp population either inhibition or successful performance that could be linked to the plankton community development and composition. The findings of this study highlighted the applicability of the metabolic theory in describing the salp ecological dynamics in the Southern Ocean.
Changes in the spatial distribution of population in urban agglomerations: A spatial-temporal perspective
Authors: Jiang Fangye , Lv Yanming 
Published: January 2022

Abstract
The spatial distribution of the urban agglomeration population has changed increasingly in rapid urbanization. It affects the urban economy, environment, transportation, and so on. Therefore, it is of great significance to understand the changes in the spatial distribution of population in urban agglomerations. This study uses methods such as population center of gravity migration and Gini coefficient to explore changes in the spatial distribution of urban populations. The study found that the population center of the Beijing-Tianjin-Hebei urban agglomeration first migrated toward Beijing and then away from Beijing. During this process, the Gini coefficient increased from 0.62 to 0.64 and then decreased to 0.58, indicating that the population balance of the urban agglomeration first increased and then decreased. This result is consistent with the conclusion that we have established a simulated urban agglomeration for theoretical derivation. That is: in the early stage of urban agglomeration development, the population migrated to the central city; as the population of the central city became saturated, the urban agglomeration developed to a mature stage, and the population began to migrate to the peripheral cities. In this process, the population distribution center of urban agglomeration gradually shifted from central towns to peripheral towns. The degree of equilibrium in the spatial distribution of population has undergone an inverted u-shaped transition from non-equilibrium to equilibrium.
Learning Spacial Domain Infectious Disease Control Model for Vaccine Distribution by Physics-Constraint Machine Learning
Authors: Li Chun , Yang Yunyun , Jiang Xin , Wu Boying 
Published: January 2022

Abstract
The coronavirus disease, COVID-19, has become a global challenging pandemic. Causing significant loss of life, property, and economics worldwide. The study of infectious disease models allows us to have a deeper understand of spreading trend of highly infectious diseases. Therefore, studying infectious disease models is imminent. In this work, we propose learning spacial domain infectious disease control model for vaccine distribution by physics-constraint machine learning. Usually, these dynamical systems are utilized in epidemiology models to predict the time evolution and development trend of highly infectious diseases such as COVID-19. We reformulate the SIR models and give corresponding policies via dynamical systems. More importantly, we obtain the approximating numerical solution of the systems of dynamical PDEs via the PINNs algorithm, within the acceptable range of approximation error. Additionally, we present several numerical solutions of the PDEs under a variety of scenarios.
Whole-Genome Sequencing and Analysis of Nutritional Traits in a Core Set of Ethiopian Teff (Eragrostis tef) Varieties
Authors: Ereful Nelzo C , Jones Huw , Fradgley Nick , Boyd Lesley , Cherie Hirut Assaye , Milner Matthew J 
Published: January 2022

Abstract
Background: Teff (Eragrostis teff) is a tropical cereal domesticated and grown in the Ethiopian highlands, where it has been a staple food of Ethiopians for many centuries. Food insecurity and nutrient deficiencies are major problems in the country, so breeding for enhanced nutritional traits, such as Zn content, could help to alleviate problems with malnutrition. Results: To understand the breeding potential of nutritional traits in teff a core set of 24 varieties were sequenced and their mineral content, levels of phytate and protein, as well as a number of nutritionally valuable phenolic compounds measured in grain. Significant variation in all these traits was found between varieties. Genome wide sequencing of the 24 teff varieties revealed 3,193,582 unique SNPs and 897,272 unique INDELs relative to the teff reference var. Dabbi. Sequence analysis of two key transporter families involved in the uptake and transport of Zn by the plant led to the identification of 32 Zinc Iron Permease (ZIP) transporters and 14 Heavy Metal Associated (HMA) transporters in teff. Further analysis identified numerous variants, of which 14.6% of EtZIP and 12.4% of EtHMA variants were non-synonymous changes. Analysis of a key enzyme in flavanol synthesis, flavonoid 3’-hydroxylase (F3’H), identified a T-G variant in the teff homologue Et_s3159-0.29-1.mrna1 that was associated with the differences observed in kaempferol glycoside and quercetin glycoside levels. Conclusion: Wide genetic and phenotypic variation was found in 24 Ethiopian teff varieties which would allow for breeding gains in many nutritional traits of importance to human health.
Genetic study for some body weight and egg traits in Domyati and Khaki-Campbell ducks.
Authors: EL-Deghadi Amira soliman , Ali Wael Ali , Gharib Mahmoud Gharib 
Published: January 2022

Abstract
The duck industry makes an important contribution to the availability of animal protein sources in Egypt, however little known about the genetic factors, particularly the heritability and genetic correlations of body weight and egg production in ducks. Body weight is the most essential feature for genetic improvement due to its ease of selection, high heredity, and large impact on meat production costs. The target of this study was to evaluate and explain genetic traits such as the heritability, the genetic and phenotypic correlations, and sire breeding value in Domyati (local) and Khaki-Campbell (foreign) ducks in order to improve body weight and egg traits. A total of 160 (80 Domyati and 80 Khaki-Campbell ducks utilized to measure body weight (at 16 and 20 weeks g), as well as 7000 eggs (2500 Domyati and 4500 Khaki-Campbell) to measure egg traits (the egg number, egg weight, and egg mass are all measured throughout the first 90 days of laying). In Domyati and Khaki-Campbell ducks, the heritability estimated for body weight was moderate to high, ranged from 0.35 to 0.40, and 0.21 to 0.30 for egg production, and the genetic correlations among body weight and egg traits were all positive and had high values, 21 and among BW16 and BW20 were stronger than between other traits (0.90); (99). The genetic improvement in BW16 could be followed by an increase in BW20 weeks
Identification of Substrate-specific Allosteric Fingerprints in Matrix Metalloprotease-1 on Amyloid-beta Peptide Aggregates and Drug Screening With Single Molecule Insights
Authors: Kamboj Sumaer , Harms Chase , Wright Derek , Nash Anthony , Klein-Seetharaman Judith , Sarkar Susanta K. 
Published: January 2022

Abstract
Amyloid-beta peptide (Aβ) is the primary component of water-insoluble extracellular plaques, one of the critical hallmarks of Alzheimer's disease (AD). Matrix metalloproteases (MMPs) are broad-spectrum proteases with diverse functions, including interactions with Aβ. Here we report single molecule measurements of MMP1 dynamics on Aβ-induced aggregates by calculating Forster Resonance Energy Transfer (FRET) between two dyes attached to the catalytic and hemopexin domains. We show that the two domains of MMP1 prefer closed conformations on Aβ-induced aggregates, in contrast to the preference for open conformations on collagen fibril, fibrin, and alpha-synuclein aggregates. We approximated the MMP1 dynamics by a two-state Poisson process and determined the kinetic rates of interconversion between the two states from histograms and correlations of FRET values. We performed molecular docking of MMP1 with Aβ using ClusPro, simulated MMP1 dynamics using different docking poses, and matched the experimental and simulated interdomain dynamics to identify an appropriate pose. We used simulations to create a two-dimensional map of correlations between every pair of MMP1 residues, which shows allosteric communications between the two MMP1 domains. We calculated a Gray Level Co-occurrence Matrix from the two-dimensional map of correlations and quantified MMP1 fluctuations by Shannon entropy. We identified the allosteric residues in the hemopexin domain by identifying residues having strong correlations with the catalytic motif residues. We identified that the residues I364, G369, P409, G410, and D418 in MMP1 have Aβ-specific allosteric correlations with the MMP1 catalytic motif by comparing residues for free and Aβ-bound MMP1. We used these Aβ-specific allosteric residues to select small molecule ligands after the virtual screening of molecules against Aβ-bound MMP1. Molecular understanding of interactions between MMP1 and Aβ-induced aggregates and identification of substrate-specific allosteric residues may enable controlling MMP1 function selectively on Aβ.
Single-port Transaxillary Robotic Radical Neck Dissection (STAR-RND): Initial Experience of 30 Cases
Authors: Ho Joon , Kim Donggyu , Lee Ji-Eun , Kim Jin Kyong , Lee Cho Rok , Kang Sang-Wook , Jeong Jong Ju , Nam Kee-Hyun , Chung Woong Youn 
Published: January 2022

Abstract
This study aimed to demonstrate the usefulness of single-port transaxillary robotic radical neck dissection (STAR-RND) for metastatic thyroid cancer, and its potential to make small and invisible surgical wounds possible compared to open modified radical neck dissection. Between January 2020 and July 2021, 30 thyroid cancer patients who underwent lateral neck dissection surgery with the da Vinci SP at Yonsei University Health System (Seoul, Korea) were studied. All 30 patients, diagnosed with papillary thyroid cancer were women. The average operating time was 293.80 ± 36.58 (minutes), and the average postoperative hospital stay was 4.77 ± 0.57 (days). All patients were discharged after the expected number of hospitalization days without major complications.STAR-RND is technically feasible and safe with a short length of the incision. To our knowledge, this is the first report on the use of a single-port robotic system for radical neck dissection.
Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection Protects Against Myocardial Ischemia-Reperfusion Injury and Heart Failure
Authors: Kong Shang , Zhou Dan , Fan Qinghong , Zhao Tingting , Ren Chunguang , Nie Hong 
Published: January 2022

Abstract
Backgrounds
Myocardial ischemia-reperfusion (MIR) injury is a common stimulus for cardiac diseases like cardiac arrhythmias, heart failure and may cause high mortality rates. Salviae miltiorrhizae liguspyragine hydrochloride and glucose injection (SGI) has been widely used to treat myocardial and cerebral infarctions in China even though its pharmacological mechanisms are not completely clear.
Methods and results
The protective effect and mechanism of SGI on MIR injury and heart failure were investigated through the H9c2 cell model induced by hypoxia/reoxygenation (H/R) and rapamycin, zebrafish model induced by H/R and isoprenaline, and rat MIR model. SGI significantly reduced the infarct size and alleviated the impairment of cardiac functions in the MIR rat model and H/R zebrafish model, and promoted cell viability of cardiomyocytes-like H9c2 cells under H/R condition. Consistently, SGI significantly downregulated the serum level of biomarkers for cardiac damage and attenuate the oxidative damage in the MIR and H/R models. We also found SGI could downregulate the increased autophagy level in those MIR and H/R models since autophagy can contribute to the injurious effects of ischemia-reperfusion in the heart, suggesting that SGI may alleviate MIR injury via regulating the autophagy pathway. In addition, we demonstrated that SGI also played a protective role in the isoproterenol-induced zebrafish heart failure model, and SGI significantly down-regulated the increased autophagy and SP1/GATA4 pathways.
Conclusions
SGI may exert anti-MIR and heart failure by inhibiting activated autophagy and the SP1/GATA4 pathway.
Effects of Salinity Acclimation on Histological Characteristics and miRNA Expression Profiles of Scales in Juvenile Rainbow Trout (Oncorhynchus Mykiss)
Authors: Zhou QiLing , Wang LiuYong , Zhao XiaoLong , Yang YunSheng , Ma Qian , Chen Gang 
Published: January 2022

Abstract
Background: The scales serve as an ideal model for studying the regulatory mechanism of bone homeostasis in fish. To explore the effect of salinity acclimation on bone metabolism of juvenile rainbow trout (Oncorhynchus mykiss), three sampling time points during salinity acclimation (7D, 14D and 21D) were selected to detect variations in histological characteristics. In the histological analysis, osteoblast marker enzymes alkaline phosphatase (ALP), osteoclast marker tartrate-resistant acid phosphatase (TRAcP) and calcium salt deposit areas (Von Kossa′s) were detected. Changes in calcium (Ca), phosphorus (P) and the molar mass ratio of calcium to phosphorus (Ca/P) in the scales were also detected by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). In addition, the global MicroRNA (miRNA) expression profiles during salinity acclimation were examined using Illumina sequencing platform because of their important regulatory roles in teleost biological processes.Results: Twelve independent miRNA libraries were constructed, a total of 664 known and 92 putative novel miRNAs were identified. A total of 290 DEC miRNAs (differentially expressed miRNAs from clusters with significant trends in the cluster analysis) with five types of clustering patterns were obtained, and 5,957 DEC mRNAs (differentially expressed target genes of 22,370 DEC miRNA showed a significant trend in cluster analysis) with six types of clustering patterns were screened according to transcriptome sequencing data. To better understand the functions of the DE miRNAs, 5,957 DEC mRNAs were used for GO and KEGG analysis, and they were significantly enriched in bone metabolism related signaling pathways such as MAPK signaling pathway, Calcium signaling pathway, Wnt signaling pathway, Mineral absorption and NF-kappa B signaling pathway. Six DE miRNAs were randomly selected and their expression were verified by quantitative real-time PCR (qRT-PCR), the expression trends were consistent with the results of transcriptome sequencing.Conclusions: The DEC miRNAs identified in this study might play an important role in regulation of bone metabolism during salinity acclimation, relative genes or pathways could serve as key candidates for further studies to elucidate molecular mechanism of teleost bone metabolism, and help performing salinity acclimation and developing marine culture of salmonid species.