bluuebunny/crossref_metadata_2025_split huggingface dataset:
The genetic causes of male infertility: a Middle East and North Africa perspective
Authors: Duvuru Ruthwik , Halabi Mouhammad , Omolaoye Temidayo S. , Du Plessis Stefan S. 
Published: January 2022

Male infertility is attributable to 50% of total infertility cases and about 30% of these cases remain idiopathic. In the Middle East and North Africa region (MENA), male infertility affects about 22.6% of men of reproductive age. Male infertility is caused by a variety of factors, including endocrine disruption, exposure to toxins, lifestyle, genetic and epigenetic modifications. Genetic modifications, including chromosomal abnormalities, chromosomal rearrangements, Y chromosome microdeletions and single-gene mutations, explain for about 10-15% of infertility cases. Since genetic aberration is a key player in the pathogenesis of male infertility, it is important to explore the impact in the MENA region due to the high incidence of male infertility. Therefore, the current study aims to systematically analyse the literature regarding the impact and common causes of male infertility in the MENA region. To achieve this aim, a comprehensive literature search was performed on PubMed, Google Scholar, and Science Direct databases. Following the search, a total of 126 articles was retrieved, of which 12 were duplicates and another 69 articles did not meet the inclusion criteria, totaling the exclusion of 81 articles. Studies excluded were those that had patient populations originating outside the MENA region, review articles, non-English written articles, or studies where the patient population was under 18 years of age. Findings showed that the frequent genetic aberration leading to male infertility in these regions include Y chromosome microdeletions, gene polymorphisms or copy number variations, mitochondrial microdeletions and other genetic deletions or mutations. In lieu of this, diverse clinical genetic tests should be made available for the proper diagnosis of male infertility.
The implications of Industry 4.0 on supply chains amid the COVID-19 pandemic: a systematic review
Authors: Reza Mohammad Nurul Hassan , Jayashree Sreenivasan , Malarvizhi Chinnasamy Agamudai Nambi , Rauf Md Abdur , Jayaraman Kalaivani , Shareef Syed Hussain 
Published: January 2022

Background: COVID-19 has caused significant disruptions in supply chains. It has increased the demand for products and decreased the supply of raw materials. This has interrupted many production processes. The emerging technologies of Industry 4.0 have the potential to streamline supply chains by improving time-sensitive customized solutions during this emergency. Purpose: The study identifies the core technologies of Industry 4.0 and the role and impact of these technologies in managing the disruption caused by the COVID-19 outbreak in strengthening the supply chain resilience. Design/methodology/approach: An extensive literature review using the “Preferred Reporting Items for Systematic Review and Meta-Analysis” method was carried out on the impact of the COVID-19 pandemic on supply chains and Industry 4.0 technologies. The study was undertaken by selecting keywords validated by experts, and a search was conducted in the Scopus, ProQuest, and Google Scholar databases. Publications from the leading journals on these topics were selected. The bibliographical search resulted in 1484 articles, followed by multiple layers of filtering. Finally, the most pertinent articles were selected for review, and a total of 42 articles were analyzed. Findings: The findings of the study showed that the majority of the articles emphasized the digitalization of supply chain management, acknowledging the fundamentals, applications, and prospects, revealing the drivers and challenges of Industry 4.0 technologies to manage disruptions. Most of the authors identified IoT, big data, cloud computing, additive manufacturing, and blockchain to maintain the supply chain resilience. Originality/value: Existing literature on epidemics lacks the basics and practices of utilizing Industry 4.0 technologies in the supply chain recovery process. To fill this research gap, the study summarizes the potential of Industry 4.0 technologies to lessen supply chain disruptions caused by COVID-19. The study findings are valuable for policymakers and practitioners and contribute to supply chain management studies.
The Effect of Outsourcing Pricing Algorithms on Market Competition
Authors: Harrington Joseph E. 
Published: January 2022

A third party developer designs and sells a pricing algorithm that enhances a firm’s ability to tailor prices to a source of demand variation, whether high-frequency demand shocks or market segmentation. The equilibrium pricing algorithm is characterized that maximizes the third party’s profit given firms’ optimal adoption decisions. Outsourcing the pricing algorithm does not reduce competition but does make prices more sensitive to the demand variation, and this is shown to decrease consumer welfare and increase industry profit. This effect is larger when products are more substitutable. This paper was accepted by Joshua Gans, business strategy.
The association between socioeconomic status and the 30- and 90-day risk of infection after total hip arthroplasty
Authors: Edwards Nina M. , Varnum Claus , Nelissen Rob G. H. H. , Overgaard Søren , Pedersen Alma B. 
Published: January 2022

Aims The aim of this study was to examine whether socioeconomic status (SES) is associated with a higher risk of infections following total hip arthroplasty (THA) at 30 and 90 days. Methods We obtained individual-based information on SES markers (cohabitation, education, income, and savings) on 103,901 THA patients from Danish health registries between 1 January 1995 and 31 December 2017. The primary outcome measure was any hospital-treated infection (i.e. all infections). The secondary outcomes were further specified to specific hospital-treated infections (pneumonia, urinary tract infection, and periprosthetic joint infection). The primary timepoint was within 90 days. In addition, the outcomes were further evaluated within 30 days. We calculated the cumulative incidence, and used the pseudo-observation method and generalized linear regression to estimate adjusted risk ratios (RRs) with 95% confidence intervals (CIs) for each marker. Results The cumulative incidence of any infection at 90 days was highest in patients who lived alone (1.5% (95% CI 1.3 to 1.6)) versus cohabitant (0.7% (95% CI 0.7 to 0.8)), had the lowest educational achievement (1.1% (95% CI 1.0 to 1.2)) versus highest (0.7% (95% CI 0.5 to 0.8)), had the lowest income (1.6% (95% CI 1.5 to 1.70)) versus highest (0.4% (95% CI 0.3 to 0.5)), or had lowest savings (1.3% (95% CI 1.2 to 1.4)) versus highest (0.7% (95% CI 0.6 to 0.8)). Within 90 days, the RRs for any infection were 1.3 (95% CI 1.2 to 1.4) for patients living alone versus cohabiting, 1.2 (95% CI 1.0 to 1.3) for low education achievement versus high, 1.7 (95% CI 1.4 to 2.1) for low income versus high income, and 1.5 (95% CI 1.4 to 1.8) for low savings versus high savings. The same trends were also seen for any infections within the first 30 days. Conclusion Our study provides evidence that socioeconomic inequality adversely influences the risk of infection after THA, thus contributing to healthcare disparities and inequalities. We found that living alone, low educational achievement, low income, or low savings were associated with higher risks of infections within the first 30 and 90 days after THA. Therefore, the development of targeted intervention strategies with the aim of increasing awareness of patients identified as being at greatest risk is needed to mitigate the impact of SES on the risk of infections following THA. Cite this article: Bone Joint J 2022;104-B(2):221–226.
A comparison of the post-fusion outcome of patients with early-onset scoliosis treated with traditional and magnetically controlled growing rods
Authors: Tahir Muaaz , Mehta Dhruv , Sandhu Callum , Jones Morgan , Gardner Adrian , Mehta Jwalant S. 
Published: January 2022

Aims The aim of this study was to compare the clinical and radiological outcomes of patients with early-onset scoliosis (EOS), who had undergone spinal fusion after distraction-based spinal growth modulation using either traditional growing rods (TGRs) or magnetically controlled growing rods (MCGRs). Methods We undertook a retrospective review of skeletally mature patients who had undergone fusion for an EOS, which had been previously treated using either TGRs or MCGRs. Measured outcomes included sequential coronal T1 to S1 height and major curve (Cobb) angle on plain radiographs and any complications requiring unplanned surgery before final fusion. Results We reviewed 43 patients (63% female) with a mean age of 6.4 years (SD 2.6) at the index procedure, and 12.2 years (SD 2.2) at final fusion. Their mean follow-up was 8.1 years (SD 3.4). A total of 16 patients were treated with MCGRs and 27 with TGRs. The mean number of distractions was 7.5 in the MCGR group and ten in the TGR group (p = 0.471). The mean interval between distractions was 3.4 months in the MCGR group and 8.6 months in the TGR group (p < 0.001). The mean Cobb angle had improved by 25.1° in the MCGR group and 23.2° in TGR group (p = 0.664) at final follow-up. The mean coronal T1 to S1 height had increased by 16% in the MCGR group and 32.9% in TGR group (p = 0.001), although the mean T1 to S1 height achieved at final follow-up was similar in both. Unplanned operations were needed in 43.8% of the MCGR group and 51.2% of TGR group (p = 0.422). Conclusion In this retrospective, single-centre review, there were no significant differences in major curve correction or gain in spinal height at fusion. Although the number of planned procedures were fewer in patients with MCGRs, the rates of implant-related complications needing unplanned revision surgery were similar in the two groups. Cite this article: Bone Joint J 2022;104-B(2):257–264.
Outcomes of primary total hip arthroplasty following septic arthritis of the hip
Authors: Bettencourt Jacob W. , Wyles Cody C. , Osmon Douglas R. , Hanssen Arlen D. , Berry Daniel J. , Abdel Matthew P. 
Published: January 2022

Aims Septic arthritis of the hip often leads to irreversible osteoarthritis (OA) and the requirement for total hip arthroplasty (THA). The aim of this study was to report the mid-term risk of any infection, periprosthetic joint infection (PJI), aseptic revision, and reoperation in patients with a past history of septic arthritis who underwent THA, compared with a control group of patients who underwent THA for OA. Methods We retrospectively identified 256 THAs in 244 patients following septic arthritis of the native hip, which were undertaken between 1969 and 2016 at a single institution. Each case was matched 1:1, based on age, sex, BMI, and year of surgery, to a primary THA performed for OA. The mean age and BMI were 58 years (35 to 84) and 31 kg/m2 (18 to 48), respectively, and 100 (39%) were female. The mean follow-up was 11 years (2 to 39). Results The ten-year survival free of any infection was 91% and 99% in the septic arthritis and OA groups, respectively (hazard ratio (HR) = 13; p < 0.001). The survival free of PJI at ten years was 93% and 99% in the septic arthritis and OA groups, respectively (HR = 10; p = 0.002). There was a significantly higher rate of any infection at ten years when THA was undertaken within five years of the diagnosis of septic arthritis compared with those in whom THA was undertaken > five years after this diagnosis was made (14% vs 5%, respectively; HR = 3.1; p = 0.009), but there was no significant difference in ten-year survival free of aseptic revision (HR = 1.14; p = 0.485). The mean Harris Hip Scores at two and five years postoperatively were significantly lower in the septic arthritis group compared with the OA group (p = 0.001 for both). Conclusion There was a ten-fold increased risk of PJI in patients with a history of septic arthritis who underwent THA compared with those who underwent THA for OA with a ten-year cumulative incidence of 7%. The risk of any infection had a strong downward trend as the time interval between the diagnosis of septic arthritis and THA increased, highlighted by a 3.1-fold higher risk when THAs were performed within five years of the diagnosis being made. Cite this article: Bone Joint J 2022;104-B(2):227–234.
Pola Arus Di Perairan Kabupaten Jepara
Authors: Ranadipura Abdillah , Sugianto Denny Nugroho , Atmodjo Warsito , Suryoputro Agus Anugroho Dwi , Subardjo Petrus , Widiaratih Rikha 
Published: January 2022

Pantai Kartini adalah salah satu pantai yang berada di Kabupaten Jepara. Kabupaten jepara adalah salah satu kabupaten di Provinsi Jawa Tengah. Kabupaten ini berbatasan dengan Laut Jawa di barat dan utara, Kabupaten Pati dan Kabupaten Kudus di Timur, serta Kabupaten Demak di Selatan. Sarana transportasi Pantai kartini menuju pulau sekitar seperti pulau jepara dapat dijangkau melalui perahu - perahu wisata yang dapat dipengaruhi oleh kondisi hidro – oseanografi, termasuk arus penelitian ini adalah untuk mengetahui pola arus laut Perairan Kartini, Kabupaten Jepara. Penelitian ini diharapkan bermanfaat sebagai acuan dan dapat memberi informasi adanya pola arus laut di Perairan Pantai Kartini, Kabupaten Jepara dengan menggunakan perangkat lunak MIKE 21. Arus model diverifikasi dengan arus yang diperoleh dari hasil survey lapangan. Metode penelitian yang digunakan adalah metode kuantitatif, sedangkan metode pengambilan sampel dengan metode purposif. Pemodelan yang digunakan menggunakan data primer arus ADCP serta data sekunder pasang – surut, angin dan bathimetri yang didapat dari instansi terkait guna sebagai parameter yang dapat mempengaruhi arus model. Arus pasang surut yang diperoleh mempunyai arah dominan menuju barat daya dengan kecepatan berkisar 0.1 - 0.358 m/s. Kecepatan minimum perairan adalah 0.1 m/s dan kecepatan maksimum perairan adalah 0.358 m/s. Kartini Beach is one of the beaches located in Jepara. Jepara is one of the districts in Central Java Province.it have borders the Java Sea in the west and north, Pati and Kudus in the East, and Demak in the South. Kartini Beach have transportation facilities to the surrounding islands such as panjang Island that can be reached by tourist boats which can be influenced by hydro-oceanographic conditions, including the current.this research to determine the ocean current patterns in Kartini Beach, Jepara. This research is expected to be useful as a reference and can inform the existence of patterns of ocean currents in the waters of Kartini Beach, Jepara,using a current model created by MIKE 21 software. Current models are verified by currents obtained from the results of field surveys. The research method used is a quantitative method, while the sampling method with a purposive method. The model primary data uses field current data using ADCP and secondary data such as tidal, wind and bathymetry obtained from relevant government company as parameters that can influence the flow of the model. The tidal currents obtained have the dominant direction to the southwest with speeds ranging from 0.1 - 0.358 m/s. The minimum water velocity is 0.1 m / s and the maximum speed of the waters is 0.358 m/s.
Analisis Genangan Akibat Pasang Air Laut di Kabupaten Brebes
Authors: Wijaya Putranto Kondang , Sugianto Denny Nugroho , Muslim Muslim , Ismanto Aris , Atmodjo Warsito , Widiaratih Rikha , Hariyadi Hariyadi 
Published: January 2022

Kecamatan Brebes, Kabupaten Brebes merupakan daerah potensial di bidang pertanian dan perikanan. Sebagian besar wilayah pesisir Kecamatan Brebes digunakan untuk tambak. Namun wilayah ini memiliki masalah yaitu banjir pasang yang menggenangi lahan tambak dan merusak fasilitas umum. Penelitian ini bertujuan untuk mengetahui karakteristik pasang surut, elevasi muka air laut, laju kenaikan muka air laut, dan luas wilayah genangan banjir pasang. Metode yang digunakan adalah metode kuantitatif dengan menggunakan pendekatan Sistem Informasi Geografis (SIG) untuk membuat model genangan banjir pasang dalam bentuk peta. Data yang digunakan berupa data pasang surut, DEM (Digital Elevation Model), data titik genangan banjir pasang, Peta Rupabumi Indonesia tahun 2001, dan citra GeoEye1 perekaman tahun 2017. Diketahui bahwa tipe pasang surut di perairan Kecamatan Brebes adalah campuran condong ke harian ganda dengan elevasi muka air laut yang terukur sebesar 84,2 cm untuk nilai muka air laut rerata (MSL), 146,44 cm saat pasang tertinggi (HHWL), 21,85 cm saat surut terendah (LLWL). Serta nilai laju kenaikan muka air laut sebesar 3,87 cm/tahun. Sehingga luas wilayah genangan banjir pasang pada tahun 2017 sebesar 4502,23 Ha. Kemudian diprediksi pada tahun 2018 – 2022 luas wilayah genangan akan meluas berurutan tiap tahun sebesar 4690,33 Ha, 4825,11 Ha, 4966,17 Ha, 5049,19 Ha, dan 5114,74 Ha. Brebes District, Brebes Regency is a potential area in agriculture and fisheries. Most of the coastal areas of Brebes District are used for ponds. But this area has a problem is tidal flood, that flooding the ponds and damaging public facilities. This study aims to determine the characteristics of tidal, sea water elevation, sea level rise, and the tidal flood inundation area. The method used is a quantitative method using the Geographic Information System (GIS) approach to create a model of tidal flood inundation area into a maps. The data used to make the model are tides, DEM (Digital Elevation Model), Indonesia Rupabumi maps published in 2001, GeoEye1 satellite images recorded in 2017. It is known the tidal type in Brebes District coastal water is mixed tide prevailing semidiurnal with sea level measurements of 84,2 cm for mean sea level (MSL), 146,44 cm during high highest water level (HHWL), and 21,85 cm at low lowest water level (LLWL). Rate of sea level rise is calculated at 3,87 cm/year. Inundation area by tidal flood in Brebes District in 2017 is 4502,23 Ha. Then it is predicted that in 2018 – 2022 the area of inundation will extend each year by 4690,33 Ha, 4825,11 Ha, 4966,17 Ha, 5049,19 Ha, and 5114,74 Ha respectively.
Kajian Pengaruh Angin Musim Terhadap Sebaran Suhu Permukaan Laut (Studi Kasus : Perairan Pangandaran Jawa Barat)
Authors: Rifai Azis , Rochaddi Baskoro , Fadika Ulha , Marwoto Jarot , Setiyono Heryoso 
Published: January 2022

Perairan Pangandaran merupakan bagian dari samudera Indonesia dan mendapat pengaruh sistem angin musim. Dinamika arah dan kecepatan angin musim berpengaruh terhadap dinamika arus permukaan di perairan Pangandaran. Pergerakan arus permukaan berpengaruh terhadap sebaran suhu permukaan laut perairan Pangandaran. Tujuan penelitian adalah untuk mengetahui perubahan arah dan kecepatan angin musim dan kaitannya terhadap sebaran suhu permukaan laut di perairan Pangandaran. Penelitian ini dilaksanakan pada bulan Agustus 2013. Penelitian menggunakan metode kuantitatif. Analisa statistik digunakan untuk mengetahui nilai error suhu permukaan laut yang didapat berdasar citra MODIS. Berdasarkan hasil penelitian diketahui bahwa pada musim Barat angin dominan bertiup dari arah Barat Daya menuju ke Timur Laut dengan kecepatan 5,7 – 8,8 knot, sedangkan arus permukaan bergerak ke Timur dengan kecepatan rata – rata 0,4 knot. Pada musim Timur angin dominan bertiup dari arah Timur menuju Barat dengan kecepatan 8,8 – 11,1 kno,t sedangkan arus permukaan bergerak ke Barat Laut dengan kecepatan rata – rata 0,18 knot. Sedangkan pada musim Peralihan tidak menunjukkan pengaruh arah dan kecepatan angin terhadap arah arus permukaan. Pada musim Peralihan didapatkan suhu permukaan laut yang maximum yaitu 31,7oC dan minimum yaitu 25,4oC sepanjang tahun. Pangandaran waters is a part of the Indonesian ocean and are affected by the monsoon system. The dynamics of the direction and speed of monsoons affect the dynamics of surface currents in Pangandaran waters. The flow of surface currents affects the distribution of sea surface temperature in Pangandaran waters. The purpose of this study was to determine the dynamics of direction and speed of monsoon winds and their relationship to the distribution of sea surface temperatures in Pangandaran waters. This research was conducted in August 2013. The research used quantitative methods. Statistical analysis wss used to determine the error of sea surface temperature obtained from the MODIS image. The results of the study showed that in the West monsoon the dominant wind blows from the Southwest toward the Northeast with speeds of 5.7 - 8.8 knots, while surface currents flow to the Eastward with an average speed of 0.4 knots. In the East monsoon the dominant wind blows from East to West with a speed of 8.8 - 11.1 knot, while surface currents flow to the Northwestward with an average speed of 0.18 knots. Whereas in the Transition monsoon did not show the influence of wind direction and speed on the direction of surface currents. During the Transition monsoon, the maximum sea surface temperature is 31.7oC and the minimum is 25.4oC throughout the year.
Studi Komparasi Hasil Pengolahan Pasang Surut Dengan 3 Metode (Admiralty, Least Square Dan Fast Fourier Transform) Di Pelabuhan Malahayati, Banda Aceh
Authors: Ichsari Lintang Fauzia , Handoyo Gentur , Setiyono Heryoso , Ismanto Aris , Marwoto Jarot , Yusuf Muh , Rifai Azis 
Published: January 2022

Pelabuhan Malahayati menjadi alur lintas serta tempat sandar bagi peti kemas domestik. Untuk menjalankan aktifitas pelabuhan secara optimal serta merencanakan pembangunan pelabuhan, pengetahuan mengenai tipe dan karakteristik pasang surut sangat penting. Pengolahan data pasang surut dengan berbagai metode dapat memberikan hasil yang berbeda-beda. Tujuan penelitian ini adalah untuk mengetahui karakteristik pasang surut dan komponen harmonik pembangkit pada lokasi penelitian, mengetahui perbandingan hasil pengolahan pasang surut dengan metode admiralty, least square dan fast fourier transform. Serta melakukan prediksi elevasi pasang surut dengan metode least square pada waktu setelah penelitian. Validasi hasil pengolahan pasang surut dilakukan dengan menghitung nilai RMSE hasil pengolahan metode least square terhadap data lapangan. Ketiga metode menghasilkan tipe pasang surut Pelabuhan Malahayati yaitu tipe pasang surut harian ganda. Metode admiralty menghasilkan 9 komponen utama pasang surut, sedangkan metode least square menhasilkan sejumlah 68 komponen. Sementara metode FFT digunakan untuk mengidentifikasi 21 komponen harmonik pasang surut Pelabuhan Malahayati. Didapatkan dominasi komponen harmonik pasang surut pada Pelabuhan Malahayati, yaitu komponen semidiurnal (M2 dan S2). Didapatkan nilai RMSE pada hasil pengolahan sebesar 32 cm, sedangkan RMSE hasil prediksi sebesar 64 cm. Perbedaan nilai formzhal kurang dari 0.02 sedangkan perbedaan nilai amplitudo masing-masing komponen pasang surut kurang dari 0.1 meter. Malahayati Port serves as crossing lane and transit for domestic container ships. To carry out port activities optimally and design port development, knowledge of the types and characteristics of the tides in the location is very important. This study was to determine the tidal characteristics and harmonic components of the Malahayati Port, to compare the results of tidal processing using 3 methods (admiralty, least square and fast fourier transform) and to predict the elevation of tides after this study using the least square method. Validation on this study was done by calculating the RMSE between least square result and field data. All of the 3 methods resulted the Malahayati Port tidal type which was semi diurnal tide. The admiralty method produced 9 major components, while the least square produced 68 of tidal harmonic components. And the FFT is used to identify 21 harmonic components of the Malahayati Port. Obtained that the dominance of the tidal harmonic component at the Malahayati Port was semidiurnal component M2 and S2. Noted that the RMSE value between least square result and field data is 32 cm, while the prediction RMSE is 64 cm. Using 3 methods the Formzhal difference is less than 0.02 while the difference in the amplitude of tidal component is less than 0.1 meters.