bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiotensin‐converting enzyme (ACE) inhibitory peptides from fermented sausages inoculated with Lactobacillus plantarum CD101 and Staphylococcus simulans NJ201
Authors: Huang Lanlan , Feng Mei‐qin , Sun Jian 
Published: April 2022

AbstractNatural ACE inhibitory peptides derived from food are considered to be an effective supplement for lowering blood pressure. This study investigated the effects of Lactobacillus plantarum CD101 and Staphylococcus simulans NJ201 on proteolysis and the sequence composition of ACE inhibitory peptides in fermented sausages. The ACE inhibitory activity of the inoculated group reached the maximum values on day 35 during the production of fermented sausages. A more positive effect in the hydrolysis of the sarcoplasmic and myofibrillar protein was observed in the inoculated group through sodium dodecyl sulphate–polyacrylamide gel electrophoresis (SDS‐PAGE). The free amino acid content of the inoculated group was 865.21 ± 12.55 mg/100 g, which was significantly higher (P < 0.05) than that of the control group. The molecular weight distribution showed a significant increase (P < 0.05) in peptides with a molecular weight less than 1 kDa in the inoculated group. A total of thirty‐four peptides with high hydrophobicity were identified by liquid chromatograph‐mass spectrometer/mass spectrometer (LC–MS/MS). Furthermore, the peptides were isolated and purified using gel filtration chromatography (GFC) and reversed‐phased high‐performance liquid chromatography (RP‐HPLC). Eleven novel peptides were identified by Nano‐LC‐ESI‐MS/MS, in which VALSLSRP with X‐Pro structure exhibited the highest ACE inhibition rate (75.36 ± 2.45%). These results indicated that mixed starters are conducive to protein degradation and the formation of peptides with high ACE inhibitory activity, especially peptides less than 1 kDa, and could be used as a functional material for antihypertensive drugs.
Homogeneities in in vitro starch digestion of compositionally heterogenous white wheat breads
Authors: Sopade Peter Adeoye 
Published: April 2022

SummaryIn vitro starch digestion of five fresh and shelved white wheat breads, compositionally heterogeneous, was investigated for heterogeneities or homogeneities in digestion patterns. The breads were significantly different (P ≤ 0.05) in some chemical and functional properties. The Rapid Visco‐Analyser (RVA) revealed different pasting properties in the breads, but the breads showed monophasic starch digestograms, as there were no practical slope changes or discontinuities in the digestograms. The monophasic starch digestograms were suitably described (r2 > 0.90; P ≤ 0.05) by five starch digestion kinetic models (the modified first‐order kinetic, Peleg, Paolucci‐Jeanjean, Logistic, and Weibull), and their parameters were mainly non‐significant (P > 0.05) between the breads. The heterogeneous breads were, therefore, homogeneous in their in vitro starch digestion patterns. The study also strengthens a novel modelling approach for starch digestograms to be widely used in starch digestion research, easing inter‐laboratory comparisons.
Structuring social media assessments in employee selection
Authors: Hartwell Christopher J. , Harrison Jake T. , Chauhan Rahul S. , Levashina Julia , Campion Michael A. 
Published: April 2022

AbstractSocial media assessments (SMAs) are a common, relatively new, practice in employee selection. However, SMAs are generally conducted in an informal way, leaving organizations with a practice low in reliability and validity, as well as opening up potential legal and ethical issues. We propose a framework of nine SMA structural components based on previously developed interview structural components. Effects of each component on reliability, validity, user reactions, and legality are discussed. We conduct two studies that measure the utilization of each structural component in research literature and in practice. Study 1 is a content analysis of prior SMA academic research. Results indicate the highest use for theprocedural consistencyandrating scales usedand the lowest utilization ofdocumentation. Study 2 surveyed hiring professionals to examine the structure level typically utilized for SMAs in practice. Results indicate low levels of structure for most components, which demonstrates a need for structural improvement when SMAs are used in hiring. We discuss the implications of our research and provide recommendations for structuring SMAs in both research and practice.
Clinical impact of a novel device delivery system in the diagnosis of bile duct lesions: A single‐center experience
Authors: Matsumori Tomoaki , Uza Norimitsu , Shiokawa Masahiro , Maruno Takahisa , Nishikawa Yoshihiro , Morita Toshihiro , Kuwada Takeshi , Marui Saiko , Okada Hirokazu , Taura Kojiro , Kodama Yuzo , Seno Hiroshi 
Published: April 2022

AbstractBackground and AimPathological evaluation is essential for the diagnosis of biliary tract diseases. However, existing evaluation methods have various challenges in terms of operability and diagnostic performance. The present study aimed to evaluate the feasibility, utility, and safety of a novel device delivery system for bile duct biopsy.MethodsThis study was conducted as a retrospective, descriptive analysis at a single center. Overall, 25 examinations in 14 consecutive patients who underwent transpapillary biopsies for biliary lesions using the novel device delivery system from July to November 2020 were reviewed. Number and time of biopsy, technical success rate, adequate tissue sampling rate, adverse events, and diagnostic performance of bile duct biopsies using the novel device were evaluated. Moreover, negative surgical margins were assessed in patients who underwent surgical resection after mapping biopsy.ResultsThe median number of biopsy samples was five (range: 2–13), with a median biopsy time of 11.6 min. The technical success rate was 100% (140/140), with an adequate sampling rate of 82.9% (116/140). These rates did not differ depending on the biopsy site or purpose. There were no serious adverse events related to the procedures. The diagnostic sensitivity, specificity, and accuracy of biliary stricture were 90%, 100%, and 92.3%, respectively. Negative surgical margins were confirmed in all patients undergoing surgical resection, including one patient with a surgical procedure changed based on the results of mapping biopsy.ConclusionsThe novel device delivery system has potentials in diagnosing biliary tract diseases and determining appropriate treatment strategies.
Efficacy of non‐pharmacological interventions in females with overactive bladder: A systematic review and network meta‐analysis
Authors: Chen Wenzhen , Fu Chengwei , Wu Boyu , Zhou Hong , Chen Erfei , Wu Qionghua , Yuan Juan 
Published: April 2022

AbstractAims and objectivesTo compare and rank the effectiveness of non‐pharmacological interventions for symptoms of Overactive Bladder (OAB) in network meta‐analysis.BackgroundOveractive Bladder affects many patients, which often generates bothersome symptoms and debilitates the quality of life. Non‐pharmacological therapies have been widely used in OAB. However, due to insufficient evidence, it remains unclear which strategies are most suitable for OAB.MethodsWe integrated randomised controlled trials (RCTs), which were searched up to 1 January 2021, from 8 databases (PubMed, Embase, Cochrane library, Web of Science, China National Knowledge Infrastructure, Wanfang Database, VIP Database, and China Biology Medicine disc). Studies that met the eligible criteria were assessed the risk of bias. Then, network meta‐analyses were conducted by STATA, R, and OpenBUGS. The review followed PRISMA statement.ResultsA total of 24 studies comprising 2347 patients with OAB were included in this review, most of which were low to moderate risk of bias. The results of network meta‐analysis implied that electric stimulation (ES) was the most effective intervention to reduce voided frequency and nocturia frequency of OAB.ConclusionsElectric stimulation ranked the best in the management of OAB, and future studies should pay more attention to ES.
Bayesian deep learning outperforms clinical trial estimators of intracerebral and intraventricular hemorrhage volume
Authors: Sharrock Matthew F. , Mould W. Andrew , Hildreth Meghan , Ryu E. Paul , Walborn Nathan , Awad Issam A. , Hanley Daniel F. , Muschelli John 
Published: April 2022

AbstractBackground and PurposeIntracerebral hemorrhage (ICH) and intraventricular hemorrhage (IVH) clinical trials rely on manual linear and semi‐quantitative (LSQ) estimators like the ABC/2, modified Graeb and IVH scores for timely volumetric estimation from CT. Deep learning (DL) volumetrics of ICH have recently approached the accuracy of gold‐standard planimetry. However, DL and LSQ strategies have been limited by unquantified uncertainty, in particular when ICH and IVH estimates intersect. Bayesian deep learning methods can be used to approximate uncertainty, presenting an opportunity to improve quality assurance in clinical trials.MethodsA DL model was trained to simultaneously segment ICH and IVH using diagnostic CT data from the Minimally Invasive Surgery Plus Alteplase for ICH Evacuation (MISTIE) III and Clot Lysis: Evaluating Accelerated Resolution of IVH (CLEAR) III clinical trials. Bayesian uncertainty approximation was performed using Monte‐Carlo dropout. We compared the performance of our model with estimators used in the CLEAR IVH and MISTIE II trials. The reliability of planimetry, DL, and LSQ volumetrics in the setting of high ICH and IVH intersection is quantified using consensus estimates.ResultsOur DL model produced volume correlations and median Dice scores of .994 and .946 for ICH in MISTIE II, and .980 and .863 for IVH in CLEAR IVH, respectively, outperforming LSQ estimates from the clinical trials. We found significant linear relationships between ICH uncertainty, Dice scores (r = –.849), and relative volume difference (r = .735).ConclusionIn our validation clinical trial dataset, DL models with Bayesian uncertainty approximation provided superior volumetric estimates to LSQ methods with real‐time estimates of model uncertainty.
Grounding co‐writing: An analysis of the theoretical basis of a new approach in mental health care
Authors: Faccio Elena , Pocobello Raffaella , Vitelli Roberto , Stanghellini Giovanni 
Published: April 2022

AbstractThis contribution aims to highlight the theoretical and epistemological premises of the co‐writing experience, a practice where a clinician and a patient are mutually engaged in jointly or collaboratively writing a narrative related to the patient’s experience. Unlike a typical set of therapeutic techniques, co‐writing is based on sharing perspectives and meanings about the experience of crisis, recovery, and the therapeutic process. The paper identifies and briefly describes four non‐clinical epistemological paradigms on which it is grounded: ethnography, values‐based practice, narrative care, and phenomenology. Although they differ in several ways, at the same time, they seem to share some common features that the paper investigates and comments.For clinicians, nurses, researchers and Mental Health Service managers, attention to the users and to the improvement of their active roles represents not only a strategy for the empowerment of results, but also the access door to a different perspective which relies on a renewed conceptualization of the mental disease nature that may lead to overcoming the epistemic asymmetry between the ‘expert’ and the ‘other’ in favor of intersubjective dialogue.
Effects of dietary supplementation of N‐carbamylglutamate on the haematology parameters, secondary sexual characteristics and testicular gene expression in roosters
Authors: Ma Wei , Dang De Xin , Zhang Jiehui , Wang Chunqiang , Li Desheng 
Published: April 2022

AbstractA total of 288 11‐week‐age roosters were used to evaluate the effects of dietary supplementation of N‐carbamylglutamate (NCG) on reproductive traits and testicular gene expression. The experimental periods were 12 weeks. All birds were randomly assigned to 4 treatments with 6 replicates per treatment and 12 birds per replicate. Dietary conditions were based on a basal diet and supplemented with 0%, 0.08%, 0.12%, or 0.16% NCG to form C, N1, N2 and N3 groups respectively. Dietary supplementation of NCG had positive effects on the seminiferous tubule parameters, serum gonadotropin‐releasing hormone and testosterone levels and the secondary sexual characteristics. Transcriptomics analysis was performed on the testicular tissues between C and N3 groups at the 16‐week‐age. Genes were mainly enriched in nine pathways, such as cytochrome P450 exogenous metabolism, drug metabolism, steroid hormone synthesis and glutathione metabolism, in which the ZP4 gene, cytochrome P450 family member 11A1 and other genes involved in the maintenance of gonadal function, steroid hormone biosynthesis and metabolism, and so forth, exist differences in expression levels. In summary, dietary supplementation of NCG had positive effects on the reproductive traits of roosters. NCG supplementation improved the development of reproductive traits of roosters by regulating the genes expression in testicular tissues and thus improved the synthesis of reproductive hormones in vivo.
Dysphagia thickeners in context of use: Changes in thickened drinks viscosity and thixotropy with temperature and time of consumption
Authors: Badia‐Olmos Celia , Laguna Laura , Rizo Arantxa , Tárrega Amparo 
Published: April 2022

AbstractDysphagia patients might need to thicken drinks. The viscosity of these thickened drinks varies among commercial thickeners and drinks compromising the ingesta safety. The aim of this study was to investigate how temperature and resting time affect the rheological properties of thickened drinks. Four commercial thickeners were used to thicken water, coffee, orange juice, and milk at two concentration levels used in dysphagia drinks (nectar and pudding). To study the effect of temperature, flow curves of thickened drinks at 10°C and 50°C were obtained and to study the effect of resting time, flow curves of thickened drinks at 25°C were obtained at different times (0, 30, and 60 min). All samples displayed shear‐thinning and time‐dependent behavior (thixotropy or antithixotropy). The effect of temperature on viscosity values and relative thixotropic area (RTA) depended on the thickener and the drink. Overall, apparent viscosity showed higher values at 50°C than 10°C, especially in thickeners containing starch and in drinks with higher soluble solids (milk and orange juice). This was attributed to the water absorption of pregelatinized starch granules favored by temperature. Antithixotropy was mainly observed at pudding concentration for the starch‐containing thickeners, and decreased with temperature. The effect of resting time on apparent viscosity and RTA depended also on the drink and thickener. Mostly, apparent viscosity values increased with resting time and antithixotropic behavior decreased. Both effects, increase in viscosity and decrease of antithixotropy with time, indicated that thickening action was being developed over the resting time.
Context and Generalizability in Multisite L2 Classroom Research: The Impact of Deductive Versus Guided Inductive Instruction
Authors: Moranski Kara , Zalbidea Janire 
Published: April 2022

AbstractThis study employed a multisite design to investigate the differential impact of deductive and guided inductive instruction for second language (L2) grammar development in ecologically valid classroom contexts. Students (n = 138) from eight intact third‐year L2 Spanish classes in three public high schools in the United States received deductive instruction (n = 49), guided inductive instruction via PACE (n = 49), or no explicit instruction (n = 40) on the pronoun se in non‐agentive constructions. Learning was measured with pre‐, post‐, and delayed posttests of auditory acceptability judgment and written production tasks. Multilevel models indicated that both instructional groups evidenced L2 development in producing se in non‐agentive contexts, but only deductive groups were more accurate than controls for acceptability judgments. Findings also provided evidence of overgeneralization of se, especially for deductive groups. Intraclass correlation coefficients revealed variance related to the socio‐local contexts of classrooms, teachers, and schools.
Auxin response factors are keys to the many auxin doors
Authors: Cancé Coralie , Martin‐Arevalillo Raquel , Boubekeur Kenza , Dumas Renaud 
Published: April 2022

SummaryIn plants, most developmental programs depend on the action of auxin. The best described model of the auxin signaling pathway, which explains most, but not all, of the auxin transcriptional responses, relies on a de‐repression mechanism. The auxin/indole‐3‐acetic acid repressors (Aux/IAAs) interact with the auxin response factors (ARFs), the transcription factors of the auxin signaling pathway, leading to repression of the ARF‐controlled genes. Auxin induces Aux/IAA degradation, releases ARFs and activates transcription. However, this elegant model is not suitable for all ARFs. Indeed, in Arabidopsis, which has 22 ARFs, only five of them fit into the model since they are the ones able to interact with Aux/IAAs. The remaining 17 have a limited capacity to interact with the repressors, and their mechanisms of action are still unclear. The differential interactions between ARF and Aux/IAA proteins constitute one of many examples of the biochemical and structural diversification of ARFs that affect their action and therefore affect auxin transcriptional responses. A deeper understanding of the structural properties of ARFs is fundamental to obtaining a better explanation of the action of auxin in plants.
Systematic review of electronically delivered behavioral obesity prevention interventions targeting men
Authors: Knowlden Adam P. , Wilkerson Amanda H. , Dunlap Kandyce B. , Stellefson Michael , Elijah Odunayo A. 
Published: April 2022

SummaryGlobally, obesity persists at epidemic rates. Men are underrepresented within behavior‐based obesity prevention research. As men prefer individualized, self‐guided interventions, electronic delivery of treatment modalities has potential to reach this population. The purpose of this study was to systematically review primary, secondary, or tertiary behavioral obesity prevention interventions that used controlled designs; targeted men; and incorporated at least one electronically delivered treatment modality explicitly designed to elicit an intervention effect. Literature searches were delimited to peer‐reviewed articles; published between 2000 and 2021; in the English language; and indexed in PsycINFO, CINHAL, MEDLINE, CENTRAL, and WOS electronic databases. Interventions satisfying inclusion criteria were critiqued for methodological quality using the Jadad Scale (0 = lowest quality; 10 = highest quality). Eleven studies satisfied the inclusion criteria (n = 1748; total participants) with five reporting group‐by‐time intervention effects on the primary variable targeted. Jadad scale quality assessment scores ranged from 5.00 to 9.00 with a mean of 7.72. Majority of the interventions applied a randomized control trial design (n = 10). Most interventions were theory based, with eight rooted in social cognitive theory. Behavior change strategies included self‐monitoring (n = 10), personalized feedback (n = 8), health counseling (n = 8), and goal setting (n = 9). Community‐level theories have the potential to guide future obesity prevention interventions targeting men.
Avoiding Misdiagnosis and Missed Diagnosis for Appropriately Treating Spinal Osteoid Osteomas: A Single‐Center Experience
Authors: Xu Qiming , Liu Wensheng , Xu Hairong , Cui Lijia , Li Yuan , Shan Huachao , Huang Zhen , Ma Ke , Niu Xiaohui 
Published: April 2022

ObjectivesTo analyze the causes of misdiagnosis and missed diagnosis in spinal osteoid osteoma, and to put forward solutions to improve diagnosis accuracy and treatment efficacy in patients.MethodsWe performed a retrospective cohort study on patients with spinal osteoid osteoma in Beijing Jishuitan Hospital from January 1983 to September 2019. All patients underwent surgery. The outcome measures were the extent of local pain, nocturnal pain, radicular symptoms of extremities after surgery, and reduction or disappearance of lesions on CT after surgery.ResultsThirty‐seven patients with spinal osteoid osteoma were recruited in the study. A total of 27% were female, and the mean (SD) age at diagnosis was 21.3 (8.7) years. A total of 87.0% of patients presented with nocturnal pain, and 94.7% of patients were responsive to NSAIDS treatment. The mean (SD) time from the initial onset of symptoms to the final diagnosis was 14.7 (12.5) months. Only four of 37 (10.8%) patients were correctly diagnosed with spinal osteoid osteoma on the first visit to the local hospital. CT is associated with a higher diagnosis rate than X‐ray or MRI on the first visit. Surgical navigation was used in 88.9% of patients who underwent curettage resection, and in 10% of patients who underwent en bloc resection. A total of 37 of 37 patients (100%) reported relief of local pain and radicular symptoms of extremities after surgery, and no recurrence of tumors was found during follow‐ups.ConclusionsSpinal CTs are recommended to be performed if osteoid osteoma is suspected based on clinical manifestation, including nocturnal pain and responsiveness to NSAIDS treatment, to avoid misdiagnosis and missed diagnosis of spinal osteoid osteoma.
Reaction of three potato cultivars to potato virus S and alteration of miRNAs and mRNA targets in the resistant genotypes
Authors: Yin Zhimin , Michalak Krystyna , Lebecka Renata 
Published: April 2022

AbstractReactions of three Polish potato cultivars to potato virus S (PVS) were investigated at 22°C. Cultivars Tajfun and Tonacja exhibited partial resistance with systemic infection detected in some inoculated plants; cultivar Bryza was susceptible to PVS with systemic infection detected in all inoculated plants. The virus was not detectable by ELISA at 23 days postinoculation (dpi) but was detected after 40 dpi. Infection rate and viral accumulation were significantly lower in Tonacja and Tajfun than in Bryza, but no statistically significant difference between Tajfun and Tonacja was detected. Both susceptible and resistant genotypes displayed various, either common or cultivar‐specific, symptoms. Delayed systemic infection at 56 dpi was observed in some cases in Tonacja and Tajfun. Resistance‐related alteration of a set of miRNAs and mRNA targets in the tested cultivars in response to PVS at 22°C exhibited inter‐ and intracultivar variability. The majority of tested genes were altered only in the partially resistant Tajfun and Tonacja but not in the susceptible Bryza. Enhanced expression of AGO1‐2, DCL1, stu‐miR482 and its target Gpa2 was observed in Tonacja and plants of Tajfun in which PVS was detected, with the highest induction of Gpa2 in Tajfun (30.2‐fold). However, their expression remained unchanged or decreased in plants of Tajfun in which PVS was undetected. Increased expression of stu‐miR168a and stu‐miR172e was observed in Tonacja and the PVS‐undetected plants of Tajfun, respectively, but not in the PVS‐detected plants of Tajfun. This is the first report on cultivar‐specific alteration of miRNA in a potato–PVS resistance interaction.