bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing and validating the Japanese version of the Parental Acceptance and Action Questionnaire among parents with infants and toddlers
Authors: OKAJIMA Junko , Okajima Isa 
Published: May 2022

Abstract
Background: The Parental Acceptance and Action Questionnaire (PAAQ) is a scale for evaluating a caregiver’s experiential avoidance. The Japanese version of the PAAQ (PAAQ-J) was developed by Mizusaki & Sato who highlighted the necessity to reexamine the number of the items of the PAAQ-J and its factor structure. Therefore, to appropriately evaluate the reliability and validity of PAAQ-J as formulated by Mizusaki & Sato, we conducted a survey targeting a larger-scale sample of infants and their parents. Methods: This study examines the reliability and validity of the Japanese version of the Parental Acceptance and Action Questionnaire (PAAQ-J) among 2,000 mothers of infants aged 0–3, and evaluates their scores for the PAAQ-J, the Acceptance and Action Questionnaire-II (AAQ-II), and the Hospital Anxiety and Depression Scale (HADS). Resluts: We conducted an exploratory factor analysis, further creating a PAAQ-J comprising 12 items and three factors (α = 0.80): Inaction-Behavior (Inaction-B), Inaction-Cognition (Inaction-C), and Unwillingness, with α of 0.84, 0.72 and 0.68, respectively. As in the original edition, the Confirmatory Factor Analysis results of the two-factor models show poor goodness of fit. The test re-test reliability examination results showed that the Interclass Correlation Coefficient (ICC) was 0.49, with 95% CI between 0.44 and 0.54. The correlation coefficient (r) of PAAQ-J was 0.57, 0.32 and 0.33 with AAQ-II, and depressive and anxiety symptoms in the HADS respectively.Discussion: Thus, PAAQ-J’s validity to adequately evaluate an individual’s avoidance of experiences vis-à-vis childcare, as well as their psychological flexibility, was proven. Since the original version of the PAAQ was for 6-18-year-old children with anxiety symptoms, it is necessary to examine its reliability and validity not only for infants and toddlers but also for parents of older children and adolescents in the future.
An archetypal zero- or quasi-zero-stiffness model with three degrees of freedom based upon an inverse method
Authors: Zhu Guangnan , Cao Qingjie , Chen Yushu 
Published: May 2022

Abstract
In this paper, a three degrees of freedom archetypal model with arbitrary designable features and its inverse construction method based upon the target restoring force functions are proposed. The construction conditions of the zero-stiffness and quasi-zero-stiffness systems with 3-DOF have been studied in detail, by introducing the definitions of the zero-stiffness and the quasi-zero-stiffness system, based upon the archetypal model. The static characteristic and the low-frequency vibration isolation performance of the quasi-zero-stiffness system with 3-DOF in arbitrary direction have been analyzed, by comparing with the linear system with the same support stiffness. The conclusion shows that there are finite solutions for the construction of 3-DOF zero-stiffness characteristic, and infinite solutions for the construction of 3-DOF quasi-zero-stiffness characteristic, based on 3-DOF archetypal model and its dimensionless parameters. The feasibility of constructing the zero-stiffness system with 3-DOF will lead to a new inspiration for the design of the passive zero-stiffness support structures; and the low-frequency vibration isolation performance of the 3-DOF quasi-zero-stiffness system in arbitrary direction is significantly improved compared with the linear system, which expresses a great potential in the multi-DOF design of the low-frequency, ultra-low-frequency vibration isolation.
Prediction of Physical Functioning and General Health Status Trajectories on Mortality Among Persons with Cognitive Impairment
Authors: Zang Emma , Wang Xueqing , Shi Yu , Wu Bei , Fried Terri R. 
Published: May 2022

Abstract
Background
The concern posed by the confluence of aging and cognitive impairment is growing in importance as the U.S. population rapidly ages. As such, we sought to examine the predictive power of physical functioning (PF) and general health status (GHS) trajectories on mortality outcomes among persons with cognitive impairment (PCIs).
Methods
We used group-based trajectory models to identify latent group memberships for PF trajectories in 1,641 PCIs and GHS trajectories in 2,021 PCIs from the National Health and Aging Trends Survey (2011–2018) and applied logistic regressions to predict mortality using these memberships controlling for individual characteristics.
Results
We identified six trajectory groups for PF and four groups for GHS. Trajectory group memberships for both outcomes significantly predicted mortality. For PF, group memberships largely captured the average levels over time, and worse trajectories (i.e., lower baselines and faster declines) were associated with higher odds of death. The highest mortality risk was associated with the group experiencing a sharp decline early in its PF trajectory, although its average level across time was not the lowest. For GHS, we observed two groups with comparable average levels across time, but the one with a convex-shape trajectory had much higher mortality risks compared to the one with a concave-shape trajectory.
Conclusions
Our findings highlighted that health trajectories predicted mortality among PCIs, not only because of general levels but also because of the shapes of declines. Close monitoring health deterioration of PCIs is crucial to understand the health burden of this population and to make subsequent actions.
Screening of breast cancer biomarkers based on bioinformatics analysis
Authors: Xu Yuehong , Niu Changchun 
Published: May 2022

Abstract
Breast cancer is one of the most common malignancies in women, its incidence is increasing year by year, and it seriously threatens the life and health of women. Therefore, it is necessary to find more sensitive and specific biomarkers to reveal the initial disorders and underlying mechanisms of the disease. Bioinformatics analysis of breast cancer gene chip data was performed to find expression characteristic gene profiles to screen potential biomarkers of breast cancer. GEO 2R was used for differential gene expression analysis of breast cancer chips screened in the comprehensive gene expression database, R language was used for gene function annotation GO enrichment analysis and KEGG pathway enrichment analysis, and String database was used for protein-protein interactions analysis .Finally, survival analysis was performed on the five most significantly different genes through the GEPIA online analysis website, and the differential gene expression levels in normal tissue and breast cancer tissue were verified by boxplot. Through differential analysis of cancer samples from breast cancer patients and normal breast samples, a total of 1174 differential genes were obtained, including 973 down-regulated genes and 201 up-regulated genes. The differentially expressed genes were enriched in 56 different GO subsets. By using the GEPIA online analysis website to conduct survival analysis on the five most significantly differentially expressed genes, we found that the most significantly differentially expressed gene HEPN1 has a significant relationship with the prognosis of patients. The expression levels of five genes, HEPN1, GPD1, C14orf180, TUSC5 and PLIN4 in normal breast tissue and breast cancer tissue were verified by boxplots. The boxplots showed that HEPN1, GPD1, C14orf180, TUSC5 and the expression level of PLIN4 gene in breast cancer tissue was significantly lower than that in normal breast tissue. It indicates that HEPN1, GPD1, C14orf180, TUSC5 and PLIN4 genes are expected to be potential diagnostic biomarkers for breast cancer patients. However, additional research is required to demonstrate our findings and motivate the clinical importance of HEPN1 in breast cancer.
MiR-17-5P regulates autophagy of ovarian granulosa cells in patients with polycystic ovary syndrome via targeting ATG7
Authors: 于 Xiaona , LIAN Fang , XIANG Shan , YU Yi , PANG Conghui , GUAN Lu , DONG Li , XIN Xin 
Published: May 2022

Abstract
Background: Abnormal activation of autophagy is considered to be an important mechanism of polycystic ovary syndrome (PCOS). In our earlier study, we found that the expression of autophagy-related protein 7 (ATG7) was increased in ovarian granulosa cells (GCs) of patients with PCOS. The purpose of this study was to investigate the effect of ATG7 on autophagy of ovarian GCs and further enrich the pathogenesis of PCOS.Methods: The associated microRNA of ATG7 was predicted by bioinformatics software, and the targeting relationship between them was verified by dual-luciferase reporter assay. In addition, the expressions of miR-17-5P and ATG7 in ovarian GCs were measured by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis (WB). Results: It was found that miR-17-5P was a microRNA associated with ATG7. MiR-17-5P could directly bind to the 3ʹuntranslated region of ATG7 and inhibit its expression. At mRNA level, the expression of miR-17-5P in GCs of PCOS women was significantly lower than that of normal women (P<0.01). At both mRNA and protein levels, the expression of ATG7 in GCs of PCOS women was significantly higher than that of normal women (P<0.01).Conclusion: Downregulation of miR-17-5P expression promotes autophagy of ovarian GCs by upregulating ATG7 expression, thus serving an important role in PCOS pathogenesis.
Light controlled liquefactions of non-photoresponsive crystals
Authors: Dong Weibin , Tan Shuai , Luo Jie , Ji Junyi , Wu Yong , Wang Caihong , Watanabe Masayoshi 
Published: May 2022

Abstract
The design and construction of photoresponsive compounds with solid-liquid transitions has been one of the central challenges in chemistry. Particularly, challenges remain for non-photoresponsive compounds. Herein, we show that a tiny dope of azobenzene (Azo) in conventional imidazolium-based ionic crystals could demonstrate light-switchable solid-liquid transitions with a rapid responsive speed. The mechanism is based on ordering structure changes of non-photoresponsive ionic crystals induced by photoisomerization of Azo. Imidazolium ionic regions facilitated Azo isomerization while Azo isomerization altered the molecular ordering of ionic crystals, with a result of solid-liquid transitions. The sharp solid-liquid transitions distinctively switched ionic conduction from insulator and conductor, applied in lightcontrolled capacitance and UV sensor. The supramolecular assembly of Azo in imidazolium-based ionic crystals provides a strategy into design of non-photoresponsive materials with photoliquefactions and successfully delivered responsiveness from molecules to macroscopic materials.
Health-related quality of life in severe psychotic disorders during integrated care: 5-year course, prediction and treatment implications (ACCESS II)
Authors: Rohenkohl Anja Christine , Daubmann Anne , Gallinat Jürgen , Karow Anne , Kraft Vivien , Rühl Friederike , Schöttle Daniel , Lambert Martin , Schröter Romy 
Published: May 2022

Abstract
Purpose: Studies on outcomes mapping Quality of Life (QoL) as patient-reported outcome over a longer period in severe psychotic disorders are scarce. However, such data would be particularly important for structuring, implementing and operating effective and efficient care models and for promoting satisfaction with care, service engagement and adherence.Methods: The ACCESS II study is a prospective long-term study of an integrated care model for people with severe psychotic disorders. The model includes Therapeutic Assertive Community Treatment within a cross-sectoral and interdisciplinary network. This publication analyses the course of QoL assessed with the Q-LES-Q-18 using a mixed model for repeated measures.Results: Mapping the course of QoL in N = 329 participants, there is a significant increase in the first 6 weeks of treatment (early course). Comparison to a published norm show significant lower QoL for severe psychotic disorders. The variable having a traumatic event before the age of 18 was significantly negative associated with QoL. A decrease in the severity of depressive as well as in positive symptomatology in the first six weeks after admission was associated with increase of QoL.Conclusion: Results indicate that the overall symptom burden at time of inclusion is not decisive for the perceived QoL in the long-term course while the reduction in the severity of depressive and positive symptoms is important. This means focusing even more on the treatment of depressive symptoms and include traumatherapeutic aspects in the long-term treatment of severe psychotic disorders if needed.ClinicalTrials.gov (identifier: NCT01888627)
Early-onset late gadolinium enhancement is a prognostic factor for Duchenne cardiomyopathy
Authors: James Lorraine , Menteer Jondavid , Durazo-Arvizu Ramon , Wood John C. , Ramos-Platt Leigh , Tiongson Emmanuelle , Su Jennifer A. 
Published: May 2022

Abstract
Hypothesis: Dilated cardiomyopathy (DCM) is an inevitable complication of Duchenne muscular dystrophy (DMD). Late gadolinium enhancement (LGE) on MRI occurs in DMD-related DCM, indicating myocyte death and remodeling. We hypothesize that patients with earlier onset of LGE develop a more rapid decline in heart function.Methods: We conducted a retrospective chart review, reviewing clinical data for DMD patients identified between January 2009 and July 2013. Subjects were cohorted by presence of LGE before age 14. We excluded patients in whom LGE status prior to age 14 was indeterminate. Results: Of the 41 subjects with complete data, 15 demonstrated LGE before age 14 (“early LGE”), and 26 had no LGE by age 14 (“controls”). Those with early LGE exhibited more rapid decline in LV fractional shortening (p=0.028). Patients with early LGE were younger at age of initiation of ACE inhibition (p=0.025), mineralocorticoid receptor antagonism (p= 0.0024), and beta blockade (p=0.0017), suggesting aggressive clinical management in response to abnormal MRI. There were no significant differences in LV dilation between the two groups (p=0.1547). Early LGE was not associated with obesity (p=0.32), age at loss of ambulation (p=0.31), or type of mutation. Conclusion: Early onset of myocardial fibrosis demonstrated by LGE on cardiac MRI is associated with earlier progression of cardiomyopathy despite earlier medication therapy. Identifying this risk, observed in 34% of our cohort during preadolescence, may guide medical therapy and counseling about cardiomyopathy progression. We suggest obtaining at least one MRI in DMD patients prior to age 14 to risk stratify patients.
Acute radiation syndrome: On the issues of triage, stem cell sources and immunosuppressive therapy
Authors: Nagayama Hitomi , OOi Jun 
Published: May 2022

Abstract
We treated the highly gamma- and neutron-irradiated nuclear accident victim by the criticality fission reaction. Conventional dosimetry methods posed us the risk of a treatment delay, and later established organ-oriented dose estimation METREPOL criteria is a helpful tool for rapid triage and stratification of the acute radiation syndrome (ARS) patients. Graft-versus-host disease (GVHD) is the most predominant life-threatening factor for ARS. Umbilical cord blood (UCB) provides us the rapid availability during the golden time for hematopoietic stem cell transplantation (HSCT) with lower risk of GVHD. Current advances of supportive care provide us the safer HSCT, so UCB overweigh the risk of engraftment failure and delayed hematopoietic recovery compared to the matched unrelated donor or related one haploidentical donor. UCB is an ideal stem cell source for HSCT of ARS, if the patients lack the suitable donor candidate.
Assessment of Groundwater Occurrence in a Typical Schist Belt Region in Osun State, Southwestern Nigeria using VES, Aeromagnetic Dataset, Remotely Sensed data, GIS, and MCDA Approaches
Authors: Ilugbo Olubusola Stephen , Aigbedion Isaac , Ozegin Oyamenda Kesyton , Bawallah Adesola Musa 
Published: May 2022

Abstract
This study presents modeling of groundwater potential in a Typical Schist Belt Region in Osun State, Southwestern Nigeria using Electrical Resistivity, Aeromagnetic, Remotely sensed data, and Multi-Criteria Decision Analysis (MCDA). Filtered and enhanced Landsat 8 OLI satellite imagery and Aeromagnetic lineaments were superimposed on Landsat lineaments to generate lineament intersection, which was subjected to line density in the ArcGIS environment to produce lineament intersection density. Eighty (80) Vertical Electrical Soundings (VES) using Schlumberger configuration were acquired within the study location. The manually processed VES data were subjected to a computer modeling program (Window Resist Version 1.0) to improve the manually derived geoelectric parameters. The geoelectric parameters from the VES interpretation were used to determine the second-order parameters. Integration of Electrical Resistivity, Aeromagnetic dataset, and Remotely Sensed data was subjected to Multi-Criteria Decision Analysis (MCDA) using Analytical Hierarchy Process (AHP) to model the groundwater potential of the investigated area. The finding from the groundwater potential map showed that the southern and traces in the northeastern and northwestern regions are indicative of high groundwater potential zone, while the northeastern, southeastern, southern, southwestern, and northwestern parts indicate moderate groundwater potential zone. Low groundwater potential zone was found in the southeastern and southwestern regions of the study area. Also, very low groundwater potential zone dominates the study area in the northern, northeastern, southeastern, southern, southwestern, northwestern, and central regions, which simply means that the investigated region is generally low in terms of groundwater potential. Boreholes and static water level data across the study area were used to validate the accuracy of the groundwater potential map. The prediction accuracy obtained showed that the techniques used in this study are capable of producing reliable and accurate results.
An Effective and Chemotherapy-free Strategy of All-trans Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia in All Risk Groups
Authors: Wang Huai-Yu , Gong Sha , Li Guo-Hui , Yao Yazhou , Zheng Yin-Suo , Lu Xiao-Hong , Wei Su-Hua , Qin Wei-Wei , Liu Hai-Bo , Wang Mengchang , Xi Jie-Ying , Chen Li-Mei , Zhang Xin-Xin , Zhang Hui-Yun , Zhao Chen-Yang , Zhang Cheng-Sheng , Liu Li , Wald David 
Published: May 2022

Abstract
The combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has been demonstrated to be at least equally effective to ATRA and chemotherapy (CHT) in non-high-risk acute promyelocytic leukemia (APL). However, the efficacy of ATRA-ATO compared to ATRA-ATO plus CHT in high-risk APL remains unknown. Here we performed a multi-center non-inferiority phase III study to compare the efficacy of ATRA-ATO and ATRA-ATO plus CHT in newly diagnosed all-risk APL to address this question. Patients were assigned to receive ATRA-ATO for induction, consolidation and maintenance or ATRA-ATO plus CHT for induction followed by three cycles of consolidation therapy, and maintenance therapy with ATRA-ATO. In the non-CHT group, hydroxyurea was used to control leukocytosis. A total of 128 patients were treated. The complete remission rate was 97% in both groups. The 2-year disease-free, event-free survival rates were 98% v 97% and 95% v 92% in the non-CHT group and CHT group in all-risk patients (P=0.62 and P=0.39, respectively). And they were 94% v 87% and 85% v 78% in the high-risk patients (P=0.52 and P=0.44, respectively). This study demonstrated that ATRA-ATO had the same efficacy as the ATRA-ATO plus CHT in the treatment of patients with all-risk APL.
Narrative Descriptive Reports on Public Health Impact of Conflict Among War-affected Zones at Amhara Region,2022
Authors: Abebaw Nigusie , Mekonen Hussen , Animut Yaregal , Tefera Zenebe , Walle Feseha , Zeleke Adugna 
Published: May 2022

Abstract
Introduction: Armed conflicts result in the interruption of clinical services, public health services, and other health-related programs and damage to the health facilities and their infrastructures Objective: This study aimed to assess the impact of conflict on public health within the war-affected zones of the Amhara region.Method: a descriptive cross-sectional study was conducted in the Amhara region. Document review and interview administered questionnaires were employed for collecting the data during the study period. Result: Based on this assessment; more than 51% of health facilities and their infrastructures were damaged and looted. About 10,333 patients on chronic disease follow-up had interrupted their treatment and follow-up for more than three to six months. And also, more than 29632 civilians died in the conflict-sourced war. Maternal and child health services have been interrupted for more than70, 000 pregnant & lactating mothers. 1035 unwanted pregnancies and 934 sexual gender-based violence (SGBV) have been occurred due to the conflictConclusion: about 51% of health facilities in the region were damaged; following this essential health services such as chronic follow non-communicable and chronic infectious disease, maternal health services, and child health services have been interrupted in the affected zones. This had led to the occurrence of maternal mortality of 233 &child mortality of 166 among those who lived in the affected area. Therefore, it needs Rapid strengthening of mobile health services, and the re-establishment of health facilities buildings and their infrastructures to reduce future morbidity and mortality
Outer Van-Allen Radiation Belt Response to VLF Plasma Waves: Application of Granger Causality Method to Radiation Belt Storm Probe-A Data
Authors: Shah Asif 
Published: May 2022

Abstract
Granger causality analysis is applied to very-low-frequency (VLF) waves and relativistic electrons interaction in an outer Van-Allen radiation belt. The VLF wave power and electrons flux data are one hour observations of radiation belt storm probe A (RBSP-A) during 14-3-2015. The considered VLF band comprises of 24 waves and electrons flux data at 8 pitch angles is considered. It is found that every wave is not Granger causing flux gradients for all pitch angles; rather some VLF waves are more efficient than others. Specifically, flux gradients at 69 degrees pitch angles are Granger caused by 14 kHz VLF wave. Contrarily, for 90 degrees pitch angles flux gradients are Granger caused by 6 waves. These results may be helpful for understanding the dynamics of outer radiation belt.