bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life in childhood advanced cancer: from conceptualization to assessment with the Advance QoL tool
Authors: Avoine-Blondin Josianne , Dumont Émilie , Marquis Marc-Antoine , Duval Michel , Sultan Serge 
Published: August 2022

Abstract
Background
Advanced childhood cancer, a condition with no available cancer-focused treatment options, greatly impacts Quality of Life (QoL). We need appropriate assessment strategies to select adapted treatment targets, improve care and optimize communication. Our first goal was to identify the domains of patients’ QoL by combining for the first time the perspectives of patients and parents with previously collected reports in professionals. Our second goal was to develop a simple QoL assessment tool and optimize its format and content for use in the childhood advanced cancer population.

Methods
To identify QoL domains, we conducted qualitative interviews with 7 young patients (4 girls, 3 boys, aged 13 ± 4 yrs) and 9 parents (7 mothers, 2 fathers) from our treatment centre. We used inductive thematic content analysis to code and categorize respondents’ viewpoints. The first version of the tool (Advance QoL) was then drafted, and structured feedback was collected through interviews and a survey with 15 experts. We computed content validity indices.

Results
Apart from the physical, psychological, and social domains, participants insisted on four original themes: autonomy, pleasure, the pursuit of achievement, and the sense of feeling heard. This was in line with the categories found in a preliminary study involving professionals (PMID: 28137343). Experts evaluated the tool as clear, relevant, acceptable, and usable. They formulated recommendations on instructions, timeframe, and item formulations, which we implemented in the refined version.

Conclusions
Advance QoL is an innovative tool targeting key life domains in childhood advanced cancer. It is focused on preserved abilities and targets of care. The refined version is appropriate for adult respondents within families and professionals. Future studies will develop versions for young ages to collect the experience of patients themselves. This will open on future reliability, validity, sensitivity, and implementation studies.
Quantitative and qualitative analysis of the quality of life of Type 1 diabetes patients using insulin pumps and of those receiving multiple daily insulin injections
Authors: Tzivian Lilian , Sokolovska Jelizaveta , Grike Anna E. , Kalcenaua Agate , Seidmann Abraham , Benis Arriel , Mednis Martins , Danovska Ieva , Berzins Ugis , Bogdanovs Arnolds , Syundyukov Emil 
Published: August 2022

Abstract
Introduction
Insulin pump therapy represents an alternative to multiple daily injections and can improve glycemic control and quality of life (QoL) in Type 1 diabetes mellitus (T1DM) patients. We aimed to explore the differences and factors related to the T1DM-specific QoL of such patients in Latvia.

Design and methods
A mixed-method cross-sectional study on 87 adult T1DM patients included 20 pump users and 67 users of injections who participated in the quantitative part of the study; 8 pump users and 13 injection users participated in the qualitative part. Patients were invited to participate using a dedicated digital platform. Their QoL and self-management habits were assessed using specially developed questionnaires adapted to Latvian conditions. Multiple logistic regression models were built to investigate the association between social and self-management factors and patients’ QoL. In addition, qualitative analysis of answers was performed.

Results
Insulin pump users were younger, had higher incomes, and reported higher T1DM expenses than users of multiple daily injections. There were no differences in self-management between the groups; Total QoL differed at the 0.1 significance level. In fully adjusted multiple logistic regression models, the most important factor that increased Total QoL was lower T1DM-related expenses (odds ratio, OR 7.02 [95% confidence interval 1.29; 38.0]). Men and those with more years of living with T1DM had better QoL (OR 9.62 [2.20; 42.1] and OR 1.16 [1.05; 1.29], respectively), but the method of administration was not significantly associated with QoL (OR 7.38 [0.87; 62.9]). Qualitative data supported the results of quantitative analysis.

Conclusions
QoL was the main reason to use an insulin pump, while the expense was the main reason to avoid the use of it or to stop using it. Reimbursement policies thus should be considered to enable patients to choose the more convenient method for themselves.
Prevalence of venous thromboembolism and evaluation of a modified caprini risk assessment model: a single-centre, prospective cohort study involving patients undergoing lung resections for bronchiectasis
Authors: Chen Qingshan , Cai YongSheng , Zhang Zhirong , Dong Honghong , Miao Jinbai , Li Hui , Hu Bin 
Published: August 2022

Abstract
Background
Venous thromboembolism (VTE) is a common postoperative complication in general thoracic surgery, but the incidence of patients undergoing surgery for bronchiectasis was not known. The purpose of our study was to investigate the incidence of VTE in bronchiectasis patients undergoing lung resection and to evaluate the risk stratification effect of the modified caprini risk assessment model (RAM).

Methods
We prospectively enrolled patients with bronchiectasis who underwent lung resection surgery between July 2016 and July 2020.The postoperative duplex lower-extremity ultrasonography or(and) computed tomographic pulmonary angiography (CTPA) was performed to detect VTE. The clinical characteristics and caprini scores of VTE patients and non-VTE patients would be compared and analyzed. Univariate logistic regression was performed to evaluate whether higher Caprini scores were associated with postoperative VTE risk.In addition, We explored the optimal cutoff for caprini score in patients with bronchiectasis by using the receiver operating characteristic (ROC) curve.

Results
One hundred and seventeen patients were eligible based on the prospective study criteria. The postoperative VTE incidence was 8.5% (10/117). By comparing the clinical characteristics and Caprini scores of VTE and non-VTE patients, the median preoperative hospitalization (7 vs 5 days, P = 0.028) and Caprini score (6.5 vs 3,P < 0.001) were significantly higher in VTE patients. In univariate logistic regression, a higher Caprini score was associated with higher odds ratio (OR) for VTE of 1.7, 95% confidence interval (CI) was from 1.2 to 2.5 (P = 0.001), C-statistics was 0.815 in the modified caprini RAM for predicting VTE. In a multivariable analysis adjusting for preoperative hospitalization, a higher Caprini score was associated with higher odds OR for VTE of 1.8 (95%CI: 1.2–2.6, P = 0.002), C-statistics was 0.893 in the caprini RAM for predicting VTE. When taking the Caprini score as 5 points as the diagnostic threshold, the Youden index is the largest.

Conclusions
The postoperative VTE incidence in patients undergoing lung resection for bronchiectasis was 8.5%.The modified caprini RAM effectively stratified bronchiectasis surgery patients for risk of VTE and showed excellent predictive power for VTE. The patients with postoperative caprini scores = 5, should be recommended to take positive measures to prevent postoperative VTE.

Trial Registration
Chinese Clinical Trial Register: ChiCTR-EOC-17010577.
Developing key performance indicators for the Canadian chiropractic profession: a modified Delphi study
Authors: Blanchette Marc-André , Mior Silvano , Thistle Shawn , Stuber Kent 
Published: August 2022

Abstract
Background
The purpose of this study is to develop a list of performance indicators to assess the status of the chiropractic profession in Canada.

Method
We conducted a 4-round modified Delphi technique (March 2018–January 2020) to reach consensus among experts and stakeholders on key status indicators for the chiropractic profession using online questionnaires. During the first round, experts suggested indicators for preidentified themes. Through the following two rounds, the importance and feasibility of each indicator was rated on an 11-point Likert scale, and their related potential sources of data identified. In the final round, provincial stakeholders were recruited to rate the importance of the indicators within the 90th percentile and identified those most important to their organisation.

Results
The first round generated 307 preliminary indicators of which 42 were selected for the remaining rounds, and eleven were preferentially selected by most of the provincial stakeholders. Experts agreed the feasibility of all indicators was high, and that data could be collected through a combination of data obtained from professional liability insurance records and survey(s) of the general population, patients, and chiropractors.

Conclusions
A set of performance indicators to assess the status of the Canadian chiropractic profession emerged from a scientific and stakeholder consensus.
To tape or not to tape: annular ligament (pulley) injuries in rock climbers—a systematic review
Authors: Larsson Robin , Nordeman Lena , Blomdahl Christina 
Published: August 2022

Abstract
Background
Popularity of rock climbing is steadily increasing. With its inclusion in the Olympic Games this will likely continue. Injuries from rock climbing are also increasing. The most common injury is to the flexor pulley system, consisting of the finger flexors and five annular ligaments (pulleys). Treatment of this injury includes taping of affected fingers, but evaluation of this treatment was previously lacking. The aim of this review was therefore to assess whether taping is associated with better outcomes than non-taping. A secondary aim was to present treatment recommendations or areas for future research.

Methods
Systematic searches of PubMed, Scopus, SPORTDiscus, Cochrane Library, PEDro and CINAHL. Free text searches of Google Scholar. Citation searching. No restrictions to language, date of publication or study design. Included studies were assessed using Cochrane scale for clinical relevance, by two independent authors. Results were presented in narrative synthesis. Certainty of evidence (GRADE) was assessed by three authors. Review was done according to PICO-protocol and reported according to PRISMA-guidelines.

Results
After removing duplicates, 595 records were identified. Eight studies and one case report (in nine articles, one poster) were included, consisting of 206 rock climbers, four non-climbers, 23 pairs of cadaver hands. Clinical relevance ranged from 0 to 5 (median 2). Evidence of low to moderate certainty suggests that taping might reduce bowstringing of the finger flexor tendons by 15–22%. Evidence regarding pain, time for return to sports, shearing forces against pulleys, pulley ruptures and maximum voluntary contraction (MVC) were all regarded as “very low”, “very low to low” or “low”, and were not considered reliable. Evidence of moderate certainty suggests that taping has no effect on MVC or muscle activation in uninjured rock climbers. No adverse effects of taping were reported.

Conclusion
Low to moderate evidence suggests that taping might reduce bowstringing of the finger flexor tendons. Moderate evidence suggests that taping has no effect on MVC or muscle activation in uninjured climbers. For other outcomes more studies evaluating the effects of taping are needed.
Trial registration: PROSPERO CRD42021241271, date of registration: 18-04-2021.
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature
Authors: Abu-Hanna Jeries , Patel Jigisha A. , Anastasakis Evangelos , Cohen Richard , Clapp Lucie H. , Loizidou Marilena , Eddama Mohammad M. R. 
Published: August 2022

AbstractHistone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine demethylases KDM6A and KDM6B, both of which have been implicated in a wide myriad of diseases, including blood and solid tumours, autoimmune and inflammatory disorders, and infectious diseases. Here, we review and summarise the pre-clinical evidence, both in vitro and in vivo, in support of the therapeutic potential of inhibiting H3K27-targeting demethylases, with a focus on the small-molecule inhibitor GSK-J4. In malignancies, KDM6A/B inhibition possesses the ability to inhibit proliferation, induce apoptosis, promote differentiation, and heighten sensitivity to currently employed chemotherapeutics. KDM6A/B inhibition also comprises a potent anti-inflammatory approach in inflammatory and autoimmune disorders associated with inappropriately exuberant inflammatory and autoimmune responses, restoring immunological homeostasis to inflamed tissues. With respect to infectious diseases, KDM6A/B inhibition can suppress the growth of infectious pathogens and attenuate the immunopathology precipitated by these pathogens. The pre-clinical in vitro and in vivo data, summarised in this review, suggest that inhibiting H3K27 demethylases holds immense therapeutic potential in many diseases.
Raters’ perceptions of rating scales criteria and its effect on the process and outcome of their rating
Authors: Heidari Nasim , Ghanbari Nasim , Abbasi Abbas 
Published: August 2022

AbstractIt is widely believed that human rating performance is influenced by an array of different factors. Among these, rater-related variables such as experience, language background, perceptions, and attitudes have been mentioned. One of the important rater-related factors is the way the raters interact with the rating scales. In particular, how raters perceive the components of the scales to further plan their scoring seems important. For this aim, the present study investigated the raters’ perceptions of the rating scales and their subsequent rating behaviors for two analytic and holistic rating scales. Hence, nine highly experienced raters were asked to verbalize their thoughts while rating student essays using IELTS holistic scale and the analytic scale of ESL Composition Profile. Upon analyzing the think-aloud protocols, four themes emerged. The findings showed that when rating holistically, the raters either referred to the holistic scale components to validate their ratings (validation) or had a pre-evaluation reading to rate in a more reliable way (dominancy). In analytic rating, on the other hand, the raters used a pre-evaluation scale reading in order to keep the components and their criteria to memory to evaluate the text more accurately (dominancy) or regularly moved between the text and the scale components to assign a score (oscillation). Furthermore, the results of a Wilcoxon signed-rank test showed that when using the holistic and analytic rating scales, the raters assigned significantly different scores to the texts. On the whole, the results revealed that the way the raters perceived the scale components will affect their judgement of the texts. The study also provides several implications for rater training programs and EFL writing assessment.
Research on the mechanism of emotional design in Chinese cultural and creative products
Authors: Yu Lei , Feng Xin , Wang Jingya , Kong Weixin , Chen Weiqing 
Published: August 2022

Abstract

Motivation
The empowerment of design for cultural and creative products in the digital media era is further amplified by social media platforms,its emotional and subconscious impact on users is important and profound. The development of the network economy has promoted this trend. At the same time, this trend has further promoted the growth of cultural and creative products market. However, too obscure appearance design can hardly arouse the resonance of different cultural groups in a short time. As an effective method to bridge the cultural gap between consumers, emotional design has become an important driving force for the development of cultural and creative products.

Purpose
The purpose of this study is to understand the impact of emotional factors on the willingness and preferences of ordinary consumers to buy Chinese cultural and creative products, and to further explore whether there are cognitive differences between the emotional design standards defined and promoted by professionals and the excellent design recognized by consumers according to their life experience and personal subjective emotional preferences.

Design/methodology/approach
Through the construction of the emotional design model, this study selects four award-winning products in the cultural and creative product design competition and four commercial products with high sales volume in the online stores as research cases. Through 176 valid questionnaires conducted by non-professionals, this study makes an analysis by using the structural equation.

Conclusions
The study found that consumers' preference and purchase intention of Chinese cultural and creative products are affected by emotional design standards, but the impact results depend on the interaction of many factors. At the same time, there are also significant differences in cognitive paths between them.
Wearable CNTs-based humidity sensors with high sensitivity and flexibility for real-time multiple respiratory monitoring
Authors: Kim Han-Sem , Kang Ji-Hye , Hwang Ji-Young , Shin Ueon Sang 
Published: August 2022

AbstractSensors, such as optical, chemical, and electrical sensors, play an important role in our lives. While these sensors already have widespread applications, such as humidity sensors, most are generally incompatible with flexible/inactive substrates and rely on conventional hard materials and complex manufacturing processes. To overcome this, we develop a CNT-based, low-resistance, and flexible humidity sensor. The core–shell structured CNT@CPM is prepared with Chit and PAMAM to achieve reliability, accuracy, consistency, and durability, resulting in a highly sensitive humidity sensor. The average response/recovery time of optimized sensor is only less than 20 s, with high sensitivity, consistent responsiveness, good linearity according to humidity rates, and low hysteresis (− 0.29 to 0.30 %RH). Moreover, it is highly reliable for long-term (at least 1 month), repeated bending (over 15,000 times), and provides accurate humidity measurement results. We apply the sensor to smart-wear, such as masks, that could conduct multi-respiratory monitoring in real-time through automatic ventilation systems. Several multi-respiratory monitoring results demonstrate its high responsiveness (less than 1.2 s) and consistent performance, indicating highly desirable for healthcare monitoring. Finally, these automatic ventilation systems paired with flexible sensors and applied to smart-wear can not only provide comfort but also enable stable and accurate healthcare in all environments.
Two tales of platform regimes in China’s food-delivery platform economy
Authors: Wei Haitao , Zhang Luyang , Deng Peipei , Li Guohui 
Published: August 2022

AbstractThis article brings the often-overlooked concept of the labor regime back to the study of China’s food-delivery platform workers. Two tales of platform regimes emerge: individualized platform despotism and bureaucratized platform despotism, which apply to crowdsourcing couriers and dedicated delivery couriers, respectively. This study compares these two types of platform regimes in terms of their institutional foundation and labor organization. Despite different institutional arrangements and labor organization, both types of food-delivery couriers belong to a despotic platform regime revealing workers’ subordination to the platform. In conclusion, it discusses the implications and limitations of this study.
Concomitant palonosetron ameliorates cisplatin-induced nephrotoxicity, nausea, and vomiting: a retrospective cohort study and pharmacovigilance analysis
Authors: Takemura Miho , Ikemura Kenji , Kondo Masayoshi , Yamane Fumihiro , Ueda Mikiko , Okuda Masahiro 
Published: August 2022

Abstract
Background
Cisplatin (CDDP)-induced nephrotoxicity is the most important complication of CDDP treatment. 5-Hydroxytryptamine type 3 receptor antagonists (5-HT3RAs) are widely used to prevent chemotherapy-induced nausea and vomiting (CINV). However, in patients with the triple antiemetic (neurokinin-1 receptor antagonist, 5-HT3RA, and dexamethasone) therapy, the advantage of palonosetron in comparison with other 5-HT3RAs on CDDP-induced nephrotoxicity and CINV remains unclear. In the present study, we investigated the effect of palonosetron on CDDP-induced nephrotoxicity and CINV in patients with the triple antiemetic therapy by a retrospective cohort study and a pharmacovigilance analysis.

Methods
We retrospectively analyzed the effect of 5-HT3RAs on the development of nephrotoxicity and CINV in 110 patients who received CDDP, fluorouracil, and triple antiemetic therapy for the treatment of esophageal cancer. Moreover, the effect of 5-HT3RAs on CDDP-induced nephrotoxicity was validated in patients with the triple antiemetic therapy using the Japanese Adverse Drug Event Report (JADER) database.

Results
In a retrospective study, the incidence of nephrotoxicity (≥ grade 1) in patients receiving palonosetron (18%) was significantly lower than that in patients receiving ramosetron (another 5-HT3RA) (36%, p = 0.044). Moreover, severe nephrotoxicity ≥ grade 3 was observed in one patient treated with ramosetron, whereas hematological toxicity was comparable between the two groups (p = 0.553). Furthermore, the incidence rate of CINV within 120 h following CDDP administration in patients treated with palonosetron (18%) was significantly lower than that in patients receiving ramosetron (39%, p = 0.026). JADER database analyses revealed that the reporting odds ratio of palonosetron for CDDP-induced acute kidney injury was 0.282 (95% confidence interval: 0.169–0.472).

Conclusions
The findings of the present study suggested a greater potential of palonosetron against CDDP-induced nephrotoxicity and CINV than other 5-HT3RAs in patients with the triple antiemetic therapy.
Abnormal growth of a pleomorphic leiomyosarcoma originating from the mesenteric vein associated with poor outcome after curative-intent resection: a case report
Authors: Otabe Masaya , Abe Tomoyuki , Sumi Yusuke , Yonehara Shuji , Noriyuki Toshio , Nakahara Masahiro 
Published: August 2022

Abstract
Background
A leiomyosarcoma (LMS) is a rare tumor that mainly originates from the urinary tract and digestive system; however, non-visceral organ-derived patterns are rare. Herein, we report that a vessel-derived pleomorphic LMS (PLMS) originating from the mesenteric vein has a poor prognosis even after curative-intent surgery.

Case presentation
The patient was a 41-year-old woman with no relevant medical history. The patient presented with abdominal pain and an abnormal bulge on the left lower abdomen. Magnetic resonance imaging revealed a large tumor occupying the left abdomen. Enhanced computed tomography revealed a bulky tumor with a maximum size of 13 × 13 cm with impending rupture, and a small amount of ascites was detected around the tumor. As the tumor directly invaded the small intestine and descending colon, left hemicolectomy and partial resection of the small intestine were performed. The patient was discharged on postoperative day 10, without any complications. On histopathological analysis, the tumor was diagnosed as a vessel-derived LMS with a pleomorphic pattern. The patient died due to disseminated intravascular coagulation because generalized peritonitis was induced by the super-early recurrence of the tumor 2 months after the surgery.

Conclusions
Regardless of curative-intent surgery for a vessel-derived PLMS, super-early local recurrence and distant metastasis were observed. A vessel-derived PLMS requires further investigation to determine its characteristics and therapeutic strategies to improve long-term prognosis.