bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart dual battery management system for expanding lifespan of wireless sensor node
Authors: Bathre Mukesh , Das Pradipta Kumar 
Published: November 2022

AbstractWireless sensor nodes have huge energy demand for their operations; they are deployed in remote locations for various applications like weather, industrial, satellite, construction, banking, and medical. Sensor nodes require continuous or uninterrupted power supply during their life cycles. When the available renewable power sources are not sufficient to run the system, the batteries are required to deliver a continuous and uninterrupted power supply. The main focus of proposed model is to design and develop a smart dual battery management system along with a hybrid energy harvesting model that can provide reliable and efficient power support to the sensor node. The problem under consideration also focuses on reducing the state of health degradation of batteries by applying a smart battery charging methodology using an ANFIS (adaptive neuro‐fuzzy inference system) controller. The proposed power management system ensures and meets the expected objectives such as switching of power sources, smart battery charging methodology (constant current and constant voltage [CC‐CV]), and dual battery power support using ANFIS controller. The result was obtained through the simulation and hardware prototype of the proposed system work flawlessly to meet the desired objective with partial charging and discharging of batteries for the prevention of battery degradation and also enhance the lifespan of the batteries.
Predicting kill sites of an apex predator from GPS data in different multiprey systems
Authors: Oliveira Teresa , Carricondo‐Sanchez David , Mattisson Jenny , Vogt Kristina , Corradini Andrea , Linnell John D. C. , Odden John , Heurich Marco , Rodríguez‐Recio Mariano , Krofel Miha 
Published: November 2022

AbstractKill rates are a central parameter to assess the impact of predation on prey species. An accurate estimation of kill rates requires a correct identification of kill sites, often achieved by field‐checking GPS location clusters (GLCs). However, there are potential sources of error included in kill‐site identification, such as failing to detect GLCs that are kill sites, and misclassifying the generated GLCs (e.g., kill for nonkill) that were not field checked. Here, we address these two sources of error using a large GPS dataset of collared Eurasian lynx (Lynx lynx), an apex predator of conservation concern in Europe, in three multiprey systems, with different combinations of wild, semidomestic, and domestic prey. We first used a subsampling approach to investigate how different GPS‐fix schedules affected the detection of GLC‐indicated kill sites. Then, we evaluated the potential of the random forest algorithm to classify GLCs as nonkills, small prey kills, and ungulate kills. We show that the number of fixes can be reduced from seven to three fixes per night without missing more than 5% of the ungulate kills, in a system composed of wild prey. Reducing the number of fixes per 24 h decreased the probability of detecting GLCs connected with kill sites, particularly those of semidomestic or domestic prey, and small prey. Random forest successfully predicted between 73%–90% of ungulate kills, but failed to classify most small prey in all systems, with sensitivity (true positive rate) lower than 65%. Additionally, removing domestic prey improved the algorithm's overall accuracy. We provide a set of recommendations for studies focusing on kill‐site detection that can be considered for other large carnivore species in addition to the Eurasian lynx. We recommend caution when working in systems including domestic prey, as the odds of underestimating kill rates are higher.
Expert peer facilitation of the EVERYbody Project: A randomized‐controlled evaluation of a diversity‐focused, dissonance‐based, universal body image program for college students
Authors: Ciao Anna C. , Duvall Ally , Pascual Summer , Lawley Kendall A. 
Published: November 2022

AbstractObjectiveA novel peer facilitation model was used to deliver a two session, dissonance‐based, inclusive body image intervention that critically examines how internalized size‐based oppression intersects with race, class, gender, sexuality, and ability.MethodThe EVERYbody Project was open to all college students and delivered by “expert” peer facilitators with body image and diversity experience and advanced facilitation skills. Recruitment was halted due to COVID‐19; 90 students in the Northwest US (M age = 19.83 years, SD = 2.38; 80% female‐identified, 13% male‐identified, 7% gender expansive) were randomized to receive the EVERYbody Project or a video‐based, low‐dissonance comparison intervention.ResultsAround half of students (56%) held one or more specific socially marginalized identity (26% with a racial or ethnic identity other than white and non‐Hispanic, 39% with a sexual identity other than straight, 7% with a gender identity other than cisgender). The EVERYbody Project produced greater reductions in three outcomes associated with poor body image (internalized appearance norms, body dissatisfaction, and negative affect) compared to the video intervention through 3‐month follow‐up (ps < .003) with medium between group effects. Both conditions experienced small reductions in eating disorder psychopathology over time.DiscussionExpert peer facilitation may be a viable delivery model for inclusive, diversity‐focused dissonance‐based body image programs.Public SignificanceThis study explored a novel facilitation approach for a diversity‐focused body image program for college students. A brief (4 h) dissonance‐based program was open to all college students and delivered by “expert” diverse peer leaders who were screened for facilitation readiness. Body image and related outcomes were improved through 3‐month follow‐up relative to a comparison condition, suggesting that expert peer facilitation may be a viable option for delivering universal, inclusive body image programming.
Can predators stabilize host–parasite interactions? Changes in aquatic predator identity alter amphibian responses and parasite abundance across life stages
Authors: Strasburg Miranda , Boone Michelle D. 
Published: November 2022

AbstractThe role of parasites can change depending on the food web community. Predators, for instance, can amplify or dilute parasite effects on their hosts. Likewise, exposure to parasites or predators at one life stage can have long‐term consequences on individual performance and survival, which can influence population and disease dynamics. To understand how predators affect amphibian parasite infections across life stages, we manipulated exposure of northern leopard frog (Rana pipiens) tadpoles to three predators (crayfish [Orconectes rusticus], bluegill [Lepomis macrochirus], or mosquitofish [Gambusia affinis]) and to trematode parasites (Echinostomaspp.) in mesocosms and followed juveniles in outdoor terrestrial enclosures through overwintering. Parasites and predators both had strong impacts on metamorphosis with bluegill and parasites individually reducing metamorph survival. However, when fish were present, the negative effects of parasites on survival was not apparent, likely because fish altered community composition via increased algal food resources. Bluegill also reduced snail abundance, which could explain reduced abundance of parasites in surviving metamorphs. Bluegill and parasite exposure increased mass at metamorphosis, which increased metamorph jumping, swimming, and feeding performance, suggesting that larger frogs would experience better terrestrial survival. Effects on size at metamorphosis persisted in the terrestrial environment but did not influence overwintering survival. Based on our results, we constructed stage‐structured population models to evaluate the lethal and sublethal effects of bluegill and parasites on population dynamics. Our models suggested that positive effects of bluegill and parasites on body size may have greater effects on population growth than the direct effects of mortality. This study illustrates how predators can alter the outcome of parasitic infections and highlights the need for long‐term experiments that investigate how changes in host–parasite systems alter population dynamics. We show that some predators reduce parasite effects and have indirect positive effects on surviving individuals potentially increasing host population persistence.
Local adaptation in the transgenerational response to copper pollution in the bryozoan Bugula neritina
Authors: Neylan Isabelle P. , Sih Andrew , Stachowicz John J. 
Published: November 2022

AbstractTransgenerational plasticity (TGP)—when a parent or previous generation's environmental experience affects offspring phenotype without involving a genetic change—can be an important mechanism allowing for rapid adaptation. However, despite increasing numbers of empirical examples of TGP, there appears to be considerable variation in its strength and direction, yet limited understanding of what causes this variation. We compared patterns of TGP in response to stress across two populations with high versus low historical levels of stress exposure. Specifically, we expected that exposure to acute stress in the population experiencing historically high levels of stress would result in adaptive TGP or alternatively fixed tolerance (no parental effect), whereas the population with low levels of historical exposure would result in negative parental carryover effects. Using a common sessile marine invertebrate, Bugula neritina, and a split brood design, we exposed parents from both populations to copper or control treatments in the laboratory and then had them brood copper‐naïve larvae. We then exposed half of each larval brood to copper and half to control conditions before allowing them to grow to maturity in the field. Maternal copper exposure had a strong negative carryover effect on adult offspring growth and survival in the population without historical exposure, especially when larvae themselves were exposed to copper. We found little to no maternal or offspring treatment effect on adult growth and survival in the population with a history of copper exposure. However, parents from this population produced larger larvae on average and were able to increase the size of their larvae in response to copper exposure, providing a potential mechanism for maintaining fitness and suggesting TGP through maternal provisioning. These results indicate that the ability to adjust offspring phenotype via TGP may be a locally adapted trait and potentially influenced by past patterns of exposure.
Evaluation of carbon footprint and energy input of internal combustion engine vehicles in China
Authors: Xie Jian‐bo 
Published: November 2022

AbstractLarge amounts of carbon dioxide (CO2) are discharged into air by combustion of gasoline and energy is input in a passenger internal combustion engine vehicle (ICEV) system through lifecycle phases. Thus, this study aims to evaluate the lifecycle carbon emissions and primary energy input of passenger ICEVs. With the life cycle assessment method, the calculations of carbon emission intensity and energy input intensity of materials used in lifecycle phases were made. The results show that the total lifecycle gasoline consumption of a vehicle was estimated to be 33,000 kg and the lifecycle CO2 emissions reached 81,311 kg per vehicle. Lifecycle CO2 emissions in use period occupied 89.43%, mainly attributed to the combustion of petrol. The average lifecycle CO2 emission intensity of the materials used was 2.33 kg/kg. The lifecycle carbon footprint of the passenger ICEVs was 163 g/km. The total CO2 emissions of ICEVs in Beijing were largest of all cities due to the maximum owning amount. The ratio of total lifecycle CO2 emissions of ICEVs in 13 large cities studied in this work to those of nationwide ICEVs was 0.179. Thus, more new energy vehicles will be given the prioritized choice in the future.
Innovative Fudan rT staging in endoscopic surgery for recurrent nasopharyngeal carcinoma
Authors: Li Wanpeng , Liu Qiang , Xu Haoyuan , Wang Huan , Zhang Huangkang , Liu Quan , Wang Jingjing , Hu Li , Li Houyong , Sun Xicai , Yu Hongmeng , Wang Dehui 
Published: November 2022

AbstractBackgroundAmerican Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) rT staging have great clinical impracticality. The aim of the present study was to establish a new rT staging to guide endoscopic surgery for the treatment of recurrent nasopharyngeal carcinoma (rNPC).MethodsThis surgical rT staging (named Fudan rT staging) was constructed using two significant risk factors: the distance from the tumor margin to the internal carotid artery, and dural invasion. Log‐rank and receiver operating characteristic (ROC) curve analyses were used to evaluate its effectiveness.ResultsFudan rT staging can effectively separate the overall survival (OS) and progression‐free survival (PFS) of patients with rNPC according to the different rT stages (p < 0.05). In addition, ROC analysis showed that the Fudan rT staging exhibited enhanced prognostic value for OS and PFS compared with the AJCC/UICC rT staging.ConclusionsThe innovative Fudan rT staging has a better predictive value for the survival of patients with rNPC than AJCC/UICC rT staging.
Promotion of diet‐induced obesity and metabolic syndromes by BID is associated with gut microbiota
Authors: Yan Shengmin , Zhou Jun , Zhang Hao , Lin Zhen , Khambu Bilon , Liu Gang , Ma Michelle , Chen Xiaoyun , Chalasani Naga , Yin Xiao‐Ming 
Published: November 2022

Abstract
A growing body of evidence has indicated an expanding functional network of B‐cell lymphoma 2 (BCL‐2) family proteins beyond regulation of cell death and survival. Here, we examined the role and mechanisms of BH3 interacting‐domain death agonist (BID), a pro‐death BCL‐2 family member, in the development of diet‐induced metabolic dysfunction. Mice deficient in bid (bid

−/−
) were resistant to high‐fat diet (HFD)–induced obesity, hepatic steatosis, and dyslipidemia with an increased insulin sensitivity. Indirect calorimetry analysis indicated that bid deficiency increased metabolic rate and decreased respiratory exchange ratio, suggesting a larger contribution of lipids to overall energy expenditure. While expression of several genes related to lipid accumulation was only increased in wild‐type livers, metabolomics analysis revealed a consistent reduction in fatty acids but an increase in certain sugars and Krebs cycle intermediates in bid

−/−
livers. Gut microbiota (GM) analysis indicated that HFD induced gut dysbiosis with differential patterns in wild‐type and in bid

−/−
mice. Notably, abrogation of GM by antibiotics during HFD feeding eliminated the beneficial effects against obesity and hepatic steatosis conferred by the bid deficiency. Conclusion: These results indicate that the protective role of bid‐deficiency against diet‐induced metabolic dysfunction interacts with the function of GM.
Capitalizing on paradoxical activation of the mitogen‐activated protein kinase pathway for treatment of Imatinib‐resistant mast cell leukemia
Authors: Wilhelm Thomas , Toledo Marcelo A. S. , Simons Ilka , Stuth Christian , Mohta Vrinda , Mülfarth Ronja , Nitsche Marcus , Maschke‐Neuß Karin , Schmitz Susanne , Kaiser Anne , Panse Jens , Christen Deborah , Arock Michel , Zenke Martin , Huber Michael 
Published: November 2022

AbstractPrevention of fatal side effects during cancer therapy of cancer patients with high‐dosed pharmacological inhibitors is to date a major challenge. Moreover, the development of drug resistance poses severe problems for the treatment of patients with leukemia or solid tumors. Particularly drug‐mediated dimerization of RAF kinases can be the cause of acquired resistance, also called “paradoxical activation.” In the present work we re‐analyzed the effects of different tyrosine kinase inhibitors (TKIs) on the proliferation, metabolic activity, and survival of the Imatinib‐resistant, KIT V560G, D816V‐expressing human mast cell (MC) leukemia (MCL) cell line HMC‐1.2. We observed that low concentrations of the TKIs Nilotinib and Ponatinib resulted in enhanced proliferation, suggesting paradoxical activation of the MAPK pathway. Indeed, these TKIs caused BRAF‐CRAF dimerization, resulting in ERK1/2 activation. The combination of Ponatinib with the MEK inhibitor Trametinib, at nanomolar concentrations, effectively suppressed HMC‐1.2 proliferation, metabolic activity, and induced apoptotic cell death. Effectiveness of this drug combination was recapitulated in the human KIT D816V MC line ROSAKIT D816V and in KIT D816V hematopoietic progenitors obtained from patient‐derived induced pluripotent stem cells (iPS cells) and systemic mastocytosis patient samples. In conclusion, mutated KIT‐driven Imatinib resistance and possible TKI‐induced paradoxical activation can be efficiently overcome by a low concentration Ponatinib and Trametinib co‐treatment, potentially reducing the negative side effects associated with MCL therapy.
Collaborations Between Microbes and those who Love Them
Authors: Høyland‐Kroghsbo Nina Molin 
Published: November 2022

AbstractQuorum sensing is the chemical language that enables bacteria to collaborate, share resources, and perform tasks, that individual bacteria cannot accomplish alone. Similarly, we can achieve greater things when we work as a group. Bonnie L. Bassler, recipient of this year's Wolf prize, ends her talks acknowledging her team, stating, “the group accomplishes more than the individual”. Inspired by her research subjects, she orchestrates her research via communication and exchange of ideas, often over shared public goods in the form of caffeine and sugary nutrients. Here, I highlight select insights into how vital collaborations between microbes may serve to enlighten and inspire us to work better together.
Targeting keystone species helps restore the dysbiosis of butyrate‐producing bacteria in nonalcoholic fatty liver disease
Authors: Wu Dingfeng , Liu Lei , Jiao Na , Zhang Yida , Yang Li , Tian Chuan , Lan Ping , Zhu Lixin , Loomba Rohit , Zhu Ruixin 
Published: November 2022

AbstractThe dysbiosis of the gut microbiome is one of the pathogenic factors of nonalcoholic fatty liver disease (NAFLD) and also affects the treatment and intervention of NAFLD. Among gut microbiomes, keystone species that regulate the integrity and stability of an ecological community have become the potential intervention targets for NAFLD. Here, we collected stool samples from 22 patients with nonalcoholic steatohepatitis (NASH), 25 obese patients, and 16 healthy individuals from New York for 16S rRNA gene sequencing. An algorithm was implemented to identify keystone species based on causal inference theories and dynamic intervention simulation. External validation was performed in an independent cohort from California. Eight keystone species in the gut of NAFLD, represented by Porphyromonas loveana, Alistipes indistinctus, and Dialister pneumosintes, were identified, which could efficiently restore the microbial composition of the NAFLD toward a normal gut microbiome with 92.3% recovery. These keystone species regulate intestinal amino acid metabolism and acid–base environment to promote the growth of the butyrate‐producing Lachnospiraceae and Ruminococcaceae species that are significantly reduced in NAFLD patients. Our findings demonstrate the importance of keystone species in restoring the microbial composition toward a normal gut microbiome, suggesting a novel potential microbial treatment for NAFLD.
Franck‐Condon factors within damped displacement harmonic oscillators: Solvent‐enhanced absorption and fluorescence spectra
Authors: Zhu Chaoyuan 
Published: November 2022

AbstractDamped harmonic oscillators that take into account local‐mode nuclear vibrations interacting with solvent molecules are developed into Franck‐Condon factors within displaced harmonic oscillator approximation. This is practically done by scaling an unperturbed Hessian matrix that represents local modes of force constants for molecules in a gaseous phase, and then by diagonalizing the perturbed Hessian matrix it results in direct modification of Huang–Rhys factors which represent normal modes of solute molecule perturbed by solvent environment. For highly symmetric polycyclic aromatic hydrocarbon molecules in which hydrogen atom vibrations in a solution can be scaled equally, one‐set scaling parameters constructed into damped Franck‐Condon factors can reproduce solvent‐enhanced absorption and fluorescence spectra in solution. However, for low symmetry molecules with atoms other than hydrogen and carbon atoms, multi‐set scaling parameters constructed into damped Franck‐Condon factors can also reproduce solvent‐enhanced absorption and fluorescence spectra in solution. Examples for high symmetry perylene in benzene solution with one‐set scaling parameters and for low symmetry carbazole in n‐hexane solution with multi‐set scaling parameters are given, in both cases, the present damped Franck‐Condon simulation can reproduce solvent‐enhanced absorption and fluorescence spectra in solution.
Pediatric dental residents’ on‐call experience
Authors: Calvo Jean Marie , Hasan Umer 
Published: November 2022

AbstractPurpose/ObjectivesThe Commission on Dental (CODA) requires that pediatric dentistry training programs provide residents with clinical experiences in oral‐facial injury and emergency care, as well as interprofessional patient care through hospital dentistry. These standards are often met through pediatric dental residents being on‐call for children's hospitals. The aim of this study was to describe the on‐call experience of pediatric dental residents at two urban children's hospitals.MethodsThis cross‐sectional descriptive study collected and analyzed data on the number, type, and time and date distributions of on‐call pages received by pediatric dental residents over a 36‐month study period.ResultsA total of 737 on‐call pages were received. Each pediatric dental resident responded to 70 pages on average during their training. The most common reason for pages being received was inpatient consultation and oral‐facial trauma. The mean number of pages received did not vary by year, month, or day of the week. There was a statically significant difference in the mean number of pages received by the hour of the day.ConclusionHaving an on‐call pediatric dental service in pediatric dentistry training programs is a meaningful way of exposing pediatric dental residents to oral‐facial trauma, hospital dentistry, and interprofessional care.