bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential links between COVID-19 and periodontitis: a bioinformatic analysis based on GEO datasets
Authors: Zhang Churen , Sun Yuzhe , Xu Min , Shu Chang , Yue Zhaoguo , Hou Jianxia , Ou Dongchen 
Published: November 2022

AbstractBackground2019 Coronavirus disease (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The COVID-19 pandemic has already had a serious influence on human existence, causing a huge public health concern for countries all around the world. Because SARS-CoV-2 infection can be spread by contact with the oral cavity, the link between oral illness and COVID-19 is gaining traction. Through bioinformatics approaches, we explored the possible molecular mechanisms linking the COVID-19 and periodontitis to provide the basis and direction for future research.MethodsTranscriptomic data from blood samples of patients with COVID-19 and periodontitis was downloaded from the Gene Expression Omnibus database. The shared differentially expressed genes were identified. The analysis of Gene Ontology, Kyoto Encyclopedia of Genesand Genomes pathway, and protein–protein interaction network was conducted for the shared differentially expressed genes. Top 5 hub genes were selected through Maximal Clique Centrality algorithm. Then mRNA-miRNA network of the hub genes was established based on miRDB database, miRTarbase database and Targetscan database. The Least absolute shrinkage and selection operator regression analysis was used to discover possible biomarkers, which were then investigated in relation to immune-related genes.ResultsFifty-six shared genes were identified through differential expression analysis in COVID-19 and periodontitis. The function of these genes was enriched in regulation of hormone secretion, regulation of secretion by cell. Myozenin 2 was identified through Least absolute shrinkage and selection operator regression Analysis, which was down-regulated in both COVID-19 and periodontitis. There was a positive correlation between Myozenin 2 and the biomarker of activated B cell, memory B cell, effector memory CD4 T cell, Type 17 helper cell, T follicular helper cell and Type 2 helper cell.ConclusionBy bioinformatics analysis, Myozenin 2 is predicted to correlate to the pathogenesis and immune infiltrating of COVID-19 and periodontitis. However, more clinical and experimental researches are needed to validate the function of Myozenin 2.
Convergence of solutions for perturbed and unperturbed cobweb models with generalized Caputo derivative
Authors: Nagy A. M. , Assidi S. , Makhlouf A. Ben 
Published: November 2022

AbstractIn this paper, continuous cobweb models with a generalized Caputo derivative called Caputo–Katugampola are investigated for both supply and demand functions and their perturbations. The convergence of each solution in the perturbed and unperturbed cases to a single equilibrium is proved. Moreover, some numerical experiments are provided to validate the theoretical results.
Domain knowledge-guided data-driven prestack seismic inversion using deep learning
Authors: Zhang Jian , Zhao Xiaoyan , Chen Yangkang , Sun Hui 
Published: November 2022

The essential task of reservoir characterization is to predict elastic/petrophysical parameters or facies from observed seismic data and evaluate their uncertainty. Deep learning-based methods gain great popularity because of their powerful ability to obtain exact solutions for geophysical inverse problems. However, those deep learning methods that use seismic data as the only input lead to difficult training and unstable inversion results (i.e., transverse discontinuity or geologic unreliability). In such circumstances, it is beneficial if prior knowledge of the model domain can be incorporated into the deep learning framework. Therefore, we have developed prior-based loss functions in the learning step of the deep learning models to ensure that the predictions find low errors on the training sets and that their results are consistent with the known prior. In addition, the Monte Carlo dropout (MC-dropout) technique is introduced for the quantitative assessment of the uncertainty of the prediction results. We determine the effectiveness of our framework in the application of prestack seismic inversion, in which the initial model built from well-log interpolation is used to design the prior-based loss function. We first perform extensive experiments on the synthetic data and find that our method can yield more stable and reliable results compared with traditional methods. Combined with the transfer learning strategy, the application to real data further demonstrates that our deep learning framework obtains more reasonable inversion results with more horizontal continuity and greater geologic reliability than traditional approaches.
Imaging of a shallow magma conduit system based on a high-power frequency-domain controlled-source electromagnetic survey
Authors: Zhou Nannan , Wei Xinhao , Zhang Shun 
Published: November 2022

Mantle-derived magma may undergo lateral flow and emplacement through horizontal magma conduits; this occurs after magma from a deep source ascends through a vertical conduit. Regardless of this understanding, the characteristics of such shallow magma conduit systems remain unclear. We have developed an image of a shallow (5 km deep) magma conduit system based on the resistivity results of a high-power frequency-domain controlled-source electromagnetic survey in the Kalatongke magmatic-type Ni-Cu deposit. The magma upwelled and ascended along the vertical fault. At shallow depths, the magma moved horizontally along the tuff layer, laterally propagating in a horizontal magma conduit. Magma extending horizontally in the horizontal tuff layer could not break through the upper, conductive, and low-density carbonaceous layer. This image provides a conduit model with vertical magma ascent and lateral magma propagation. The model provides a basis for studying shallow magma conduit systems in orogenic belts on a global scale.
Approach to the Patient With Hypothalamic Obesity
Authors: Shoemaker Ashley H , Tamaroff Jaclyn 
Published: November 2022

Abstract
Hypothalamic obesity (HO) is defined as abnormal weight gain due to physical destruction of the hypothalamus. Suprasellar tumors, most commonly craniopharyngiomas, are a classic cause of HO. HO often goes unnoticed initially as patients, families, and medical teams are focused on oncologic treatments and management of panhypopituitarism. HO is characterized by rapid weight gain in the first year after hypothalamic destruction followed by refractory obesity due to an energy imbalance of decreased energy expenditure without decreased food intake. Currently available pharmacotherapies are less effective in HO than in common obesity. While not a cure, dietary interventions, pharmacotherapy, and bariatric surgery can mitigate the effects of HO. Early recognition of HO is necessary to give an opportunity to intervene before substantial weight gain occurs. Our goal for this article is to review the pathophysiology of HO and to discuss available treatment options and future directions for prevention and treatment.
5-Hydroxyeicosatetraenoic Acid Controls Androgen Reduction in Diverse Types of Human Epithelial Cells
Authors: Hardaway Aimalie L , Goudarzi Maryam , Berk Michael , Chung Yoon-Mi , Zhang Renliang , Li Jianneng , Klein Eric , Sharifi Nima 
Published: November 2022

Abstract
Androgens regulate broad physiologic and pathologic processes, including external genitalia development, prostate cancer progression, and anti-inflammatory effects in both cancer and asthma. In prostate cancer, several lines of evidence have implicated dietary and endogenous fatty acids in cell invasion, angiogenesis, and treatment resistance. However, the role of fatty acids in steroidogenesis and the mechanisms by which alterations in this pathway occur are not well understood. Here, we show that, of a panel of fatty acids tested, arachidonic acid and its specific metabolite 5-hydroxyeicosatetraenoic acid (5-HETE) regulate androgen metabolism. Arachidonic acid is metabolized to 5-HETE and reduces androgens by inducing aldo-keto reductase (AKR) family members AKR1C2 and AKR1C3 expression in human prostate, breast, and lung epithelial cells. Finally, we provide evidence that these effects require the expression of the antioxidant response sensor, nuclear factor erythroid 2-related factor 2 (Nrf2). Our findings identify an interconnection between conventional fatty acid metabolism and steroid metabolism that has broad relevance to androgen physiology and inflammatory regulation.
Honneur et souveraineté
Authors: De Waele Michel 
Published: November 2022

PrécisL'intérêt porté par le cardinal de Richelieu aux questions maritimes est bien connu des historiens. Ceux-ci, toutefois, l'ont généralement analysé sous un angle réaliste et rationnel, notamment en fonction de la nécessité de rattraper le retard pris face aux autres puissances européennes en ce domaine et du besoin de se protéger contre les ambitions espagnoles. Or, l'essor de la marine française s'explique également par l'importance de protéger l'honneur et la réputation du roi et du royaume, particulièrement contre la volonté du roi d'Angleterre de voir reconnue sa souveraineté sur les mers.The interest shown by Cardinal Richelieu in maritime questions is well known to historians. Scholars have generally analyzed it from a realistic and rational angle, especially in terms of the need to catch up with the other European powers in this area and the need to protect the kingdom against Spanish ambitions. However, the rise of the French navy may also be explained by the need to protect the king's and the kingdom's honor and reputation, particularly against the desire of the king of England to see his sovereignty over the seas recognized.
Fear, Anger, and Rebellion
Authors: Freedman Jeffrey 
Published: November 2022

AbstractRecent protests against police violence remind us just how volatile are the emotions inspired by law enforcement. Yet despite current interest in both the history of emotions and the history of policing, these two areas of research have for the most part remained separate. This article brings them together to explore the emotional impact of policing in eighteenth-century Paris. Drawing on documents from the police archive, it shows how fears of the police's expanding influence spread through various milieus. Denizens of the night who were engaged in illicit activities lived in fear of late-night raids. Parents with young boys feared the dangers to their sons posed by seemingly indiscriminate arrests of children found loitering in the streets. Yet sometimes those police actions triggered explosions of anger. Under what conditions did fear of the police become so intolerable that it provoked rebellion rather than subjugation?Les protestations récentes contre la violence policière nous rappellent la volatilité des émotions inspirées par la police. Mais malgré l'intérêt croissant pour l'histoire des émotions et pour celle de la police, rares sont les études qui les mettent en relation. Cet article se situe à cheval entre les deux champs de recherche. Il se propose d'examiner l'impact affectif de la police parisienne au XVIIIe siècle. Il montre, sur la base de documents trouvés dans les archives de la police, comment les craintes inspirées par l'influence grandissante de la police ont touché différents milieux sociaux. Certains habitués de la vie nocturne engagés dans des activités illicites vivaient dans la crainte de rafles policières. Les parents de jeunes garçons craignaient de voir embarquer leurs enfants lors des campagnes d'arrestations apparemment arbitraires menées pour débarrasser les rues de jeunes qui y traînaient. Mais ces interventions enclenchaient parfois des mouvements de colère. Dans quelles circonstances la peur des services répressifs est-elle devenue si intolérable qu'elle ait provoqué la rébellion plutôt que l'assujettissement ?
Family Planning and Reproductive Agency in France
Authors: Bracke Maud Anne 
Published: November 2022

AbstractThe article analyzes debates on family planning, demography, and gender roles to explore the emergence of new notions of the reproductive subject in France between the 1950s and the 1970s. Drawing on papers of French and international family planning organizations, it argues that while the expansion of family planning ideology across France allowed for the discursive and practical construction of an autonomous reproductive subject, such a subject was framed by a hierarchization according to race, culture, and social class. Specifically, the analysis focuses on interventions in immigrant groups and on the French family planning movement's contribution to programs in Francophone Africa before and after decolonization. The article aims to contribute to an understanding of family planning as a transnational movement embedded in the globalization of demographic debate and the drive to normalize the nuclear family, and to an understanding of sexual change in Europe as shaped by global processes.L'article analyse les débats autour du planning familial, la démographie et les rôles des sexes pour explorer l’émergence de nouvelles idées du sujet reproductif en France entre les années 1950 et 1970. S'appuyant sur des documents d'organisations françaises et internationales, l'article soutient que l'expansion de l'idéologie du planning familial à travers la France a permis la construction discursive et pratique d'un sujet reproductif autonome, mais qu'un tel sujet était encadré par une hiérarchisation selon la race, la culture et la classe sociale. Plus précisément, l'analyse se concentre sur les interventions auprès de groupes d'immigrés en France pendant les années 1960, et sur la contribution du mouvement français de planification familiale aux programmes en Afrique francophone avant et après la décolonisation. L'article vise à contribuer à une compréhension de la planification familiale en tant que mouvement transnational ancré dans la mondialisation des débats démographiques et qui considérait la normalisation de la famille nucléaire comme œuvre civilisatrice.
THE SCREEN IS LIKE A GENERATOR OF SIMULACRA AND FAKES
Authors: Grigoryev Sergey L. 
Published: November 2022

Purpose. The article is devoted to the analysis of the screen as a special socio-cultural phenomenon that produces simulacra and fakes in modern culture. The peculiarity lies in the fact that continuous reproduction of screen technologies is supported through simulations. At the same time, screen technologies are defined as the leading factor of modern socio-cultural changes affecting the consciousness and behavior of the subject of culture – a person. His dependence on the screen is being formed, and today we can talk about the emergence of a philosophical and anthropological type of “screen man”.
Methodology. To consider the problem, the author turns to the socio-philosophical and anthropological analysis of the role of the screen in modern culture. The article uses comparative analysis, historical-philosophical and anthropological methods.
Results. The results of the study are that the author explicates the essence of Hobbes’ maxim that man can fully know only what he himself can do. As such an artifact in the philosophy of T. Hobbes is the body, and the social-political body, established by the man himself. The author supposes that the modern European project “social physics” can be considered a prototype of active theoretical-epistemic model describing social reality.
Practical implications. This allows, from the author’s point of view, to consider the role of the screen and the digital effects produced by it in modern culture, as well as to develop an integrative approach to understanding screen culture as a whole.
CONCEPTOSPHERE AS AN ELEMENT OF CULTURAL-PHILOSOPHY MODEL OF A LITERARY AND ARTISTIC WORK
Authors: Makarchuk Ivan Yu. 
Published: November 2022

The humanities are in a relentless search for optimal and more effective (compared to existing) research methods and strategies. The author of this article, as a research method, develops the general theoretical foundations of the cultural-philosophical model of a literary and artistic work, which can be used in the study of the creative heritage of various writers. The structural elements of the cultural-philosophical model of a literary and artistic work, along with the concept sphere of the corresponding literary and artistic work, include: the sum of humanitarian studies of a literary and artistic work, its main cultural and philosophical idea, genre, as well as a writer’s biography. Description of the concept sphere as an element of the cultural-philosophical model of a literary and artistic work is the purpose of this article.
The basis of the research is formed by general scientific methods and interdisciplinary methods of scientific knowledge. In the course of working on the article, the author turned to cultural and philosophical analysis, as well as content analysis of scientific literature.
Based on the results of the study, the author comes to the conclusion that one of the conditions for the productivity and completeness of the cultural-philosophical study of a literary and artistic work is the review and analysis of existing concepts. At the same time, the concept sphere is positioned as the most important means of interpreting literary and artistic works. The results of the study can be used not only in research of philosophical and cultural content, but also in works of a wide humanitarian profile, as well as in the educational process.
MANAGEMENT OF EMOTIONS AND THE SYNTAX OF RELATIONSHIPS
Authors: Lobanova Yuliya V. 
Published: November 2022

Purpose. This article explores and analyzes the first attempt in the history of Russian sociological thought to transfer the concept of “society of impressions” by G. Schulze, undertaken by the sociologist P. Aronson, to the sphere of personal relationships of individuals, and presented in the form of a mass popular scientific publication. In addition, the article examines the socio-cultural context of the modern information society, the so-called “experience economy” and the emerging practice of managing intersubjective relationships that develop in the remote access mode.
Methodology. The author turns to the socio-philosophical and sociopsychological analysis of the emotionalization of modern culture. The article uses historical-philosophical and philosophical-anthropological methods for the analytical description of the transformation of personal relationships into economic constructs.
Results. Particular attention is paid to the complexity of the genesis and definition of the essence of the interdisciplinary phenomenon of emotions in the comparability of various approaches already formed in the framework of psychology, sociology, and philosophy. The connection between individual prepositions of emotional syntax, and particular tactics of managing the process of establishing relationships is considered; mistakes are analyzed that lead to deformation of the links between the particular and the general due to wrong understanding or misunderstanding of the objective laws operating in this area.
Practical implications. The results of the study can be applied in the field of cultural studies, philosophy of culture, psychology.
Mediação Familiar Judicial: Contribuições da Análise Institucional
Authors: Rocha Juliana Toledo Araújo , Dimenstein Magda Diniz Bezerra 
Published: November 2022

Conhecida como um meio consensual de administração de conflitos, a mediação, ao lado da conciliação, está cada vez mais presente e divulgada no Brasil. No âmbito jurídico, tem sido adotada como estratégia política de reforma do Judiciário. Seu caráter interdisciplinar busca uma justiça restaurativa, não punitiva, mesclando conhecimentos do Direito, da Psicologia e da Comunicação. A mediação, especialmente, a familiar, objetiva prover famílias em conflito de ferramentas de resolução a fim de responsabilizá-las nas tomadas de decisão, bem como promover equilíbrio entre deveres e direitos, estabelecendo confiança e respeito entre seus membros. Este artigo, recorte de uma pesquisa empírica de doutorado, objetiva apresentar as contribuições da perspectiva da Análise Institucional em relação à mediação judicial no âmbito familiar, a partir de uma leitura crítica das propostas consensuais da área, apontando as "encomendas" e "demandas" feitas aos mediadores em suas práticas. Metodologicamente, adotou-se uma perspectiva qualitativa, em que foram utilizadas observação da realidade institucional e entrevistas semiestruturadas realizadas com os mediadores familiares. Elucidaram-se analisadores, emergidos da leitura dos dados construídos no campo e, em seguida, observaram-se as linhas de forças operadas nesse dispositivo.
High power 1.55  µm buried heterojunction distributed feedback laser with a linewidth less than 200  kHz
Authors: Xian Qingyun , Lv Hui , Yao Yucheng , Wei Sihang , Zhou Zhiqiang 
Published: November 2022

With the rapid development of coherent optical communication systems, lasers are required to have higher power and narrower linewidths. In this paper, a process method using buried heterojunction is proposed. By comparing the optoelectronic properties of lasers with different mesa widths and different cavity lengths, the laser with a 1000 µm cavity length and a mesa width of 2.4 µm can reach 133.7 mW at 25°C at 300 mA, and a side mode suppression ratio (SMSR) greater than 50 dB. This laser also exhibits low relative intensity noise (

<

−

150

d
B

/

H
z

at 260 mA) and narrow linewidth (

<

200

k
H
z

).
Effects of a low‐carbohydrate/high‐protein diet on metabolic health in individuals with chronic spinal cord injury: An exploratory analysis of results from a randomized controlled trial
Authors: Li Jia , Gower Barbara , McLain Amie , Yarar‐Fisher Ceren 
Published: November 2022

AbstractWe explored the impact of a low‐carbohydrate/high‐protein diet (LC/HP, ~30% energy from protein, 40% energy from carbohydrate) on indices of metabolic function and body composition in individuals with chronic spinal cord injury (SCI). Adults with SCI (≥3 years post‐injury, C4‐L2, AIS A‐D) and insulin resistance or pre‐diabetes were randomly assigned to an 8‐week iso‐caloric LC/HP diet group (n = 11) or control group (n = 14). All LC/HP meals were delivered weekly to participants' homes, and participants in the control group consumed their habitual diet. Each participant underwent an oral glucose tolerance test (OGTT) to assess glucose tolerance, insulin, area under the curve (AUC) for glucose and insulin, Matsuda Index, glucose‐stimulated insulin secretion (GSIS), disposition index, and hepatic insulin extraction (HIE). Fasting blood lipid and inflammation were assessed, and body composition was estimated using dual‐energy x‐ray absorptiometry. A linear mixed model was used to evaluate the main effect of diet, time, and their interaction. Compared to the control group, participants in the LC/HP group had reduced total body fat mass (LC/HP: −5.9%, Control: 0.7%), visceral fat mass (LC/HP: −16.2%, Control: 5.2%), total‐ (LC/HP: −20.1, Control: 3.7 mg/dl), and LDL‐cholesterol (LC/HP: −13.9, Control: 3.1 mg/dl) (pdiet*time < 0.05 for all). Regardless of group, AUCinsulin and peak insulin during the OGTT decreased, and HIE increased over time (ptime < 0.05). A trend for diet*time interaction was observed for glucoseOGTT120min (LC/HP: −20.7, Control: 3.0 mg/dl, pdiet*time = 0.09) and peak C‐peptide (LC/HP: −2.1, Control: 0.0 ng/ml, pdiet*time = 0.07). HDL‐cholesterol, lean body mass, Matsuda Index, fasting glucose, insulin, insulinOGTT120min, AUCglucose, pancreatic beta cell function (GSIS, disposition index), and inflammation (C‐reactive protein, IL‐6, IL‐8, IL‐10, TNF‐α) did not change over time. In conclusion, our results suggest that individuals with SCI and insulin resistance may adopt an LC/HP diet to improve body composition and lipid profiles. Its impact on glucose metabolism and inflammation remains inconclusive and warrants future investigations.