bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast harmonic tetrahedral mesh optimization
Authors: Ströter D. , Mueller-Roemer J. S. , Weber D. , Fellner D. W. 
Published: June 2022

AbstractMesh optimization is essential to enable sufficient element quality for numerical methods such as the finite element method (FEM). Depending on the required accuracy and geometric detail, a mesh with many elements is necessary to resolve small-scale details. Sequential optimization of large meshes often imposes long run times. This is especially an issue for Delaunay-based methods. Recently, the notion of harmonic triangulations [1] was evaluated for tetrahedral meshes, revealing significantly faster run times than competing Delaunay-based methods. A crucial aspect for efficiency and high element quality is boundary treatment. We investigate directional derivatives for boundary treatment and massively parallel GPUs for mesh optimization. Parallel flipping achieves compelling speedups by up to$$318\times $$318×. We accelerate harmonic mesh optimization by$$119\times $$119×for boundary preservation and$$78\times $$78×for moving every boundary vertex, while producing superior mesh quality.
German Cardiac Arrest Registry: rationale and design of G-CAR
Authors: Pöss Janine , Sinning Christoph , Schreiner Isabelle , Apfelbacher Christian , Drewitz Karl-Philipp , Hösler Nadine , Schneider Steffen , Pieske Burkert , Böttiger Bernd W. , Ewen Sebastian , Wienbergen Harm , Kelm Malte , Bock Daniel , Graf Tobias , Adler Christoph , Dutzmann Jochen , Knie Wulf , Orban Martin , Zeymer Uwe , Michels Guido , Thiele Holger ,   the G-CAR Investigators
Published: June 2022

Abstract
Background
In Germany, 70,000–100,000 persons per year suffer from out-of-hospital cardiac arrest (OHCA). Despite medical progress, survival rates with good neurological outcome remain low. For many important clinical issues, no or only insufficient evidence from randomised trials is available. Therefore, a systemic and standardised acquisition of the treatment course and of the outcome of OHCA patients is warranted.

Study design
The German Cardiac Arrest Registry (G-CAR) is an observational, prospective, multicentre registry. It will determine the characteristics, initial treatment strategies, invasive procedures, revascularisation therapies and the use of mechanical circulatory support devices with a focus on extracorporeal cardiopulmonary resuscitation. A special feature is the prospective 12-month follow-up evaluating mortality, neurological outcomes and several patient-reported outcomes in the psychosocial domain (health-related quality of life, cognitive impairment, depression/anxiety, post-traumatic stress disorder and social reintegration). In a pilot phase of 24 months, 15 centres will include approximately 400 consecutive OHCA patients ≥ 18 years. Parallel to and after the pilot phase, scaling up of G-CAR to a national level is envisaged.

Conclusion
G-CAR is the first national registry including a long-term follow-up for adult OHCA patients. Primary aim is a better understanding of the determinants of acute and long-term outcomes with the perspective of an optimised treatment.

Trial registry
NCT05142124.

Graphical abstract
German Cardiac Arrest Registry (G-CAR)
Regorafenib for recurrent high-grade glioma: a unicentric retrospective analysis of feasibility, efficacy, and toxicity
Authors: Treiber Hannes , von der Brelie Christian , Malinova Vesna , Mielke Dorothee , Rohde Veit , Chapuy Claudia Ilse 
Published: June 2022

AbstractWe describe here 11 consecutive patients with recurrence of high-grade glioma treated with regorafenib at our university medical center. The majority of patients had MGMT promoter methylation (9/11 cases). Regorafenib was given as 2nd line systemic treatment in 6/11 patients and 3rd or higher line treatment in 5/11 patients. The median number of applied cycles was 2 with dosage reductions in 5/11. Response to treatment was observed in 4/11 (PR in 1/11, and SD in 3/11). Median overall survival for the cohort was 16.1 months, median progression-free survival 9.0 months, and median time to treatment failure 3.3 months. Side effects of any CTCAE grade were noted in all patients, hereby 6/11 with CTCAE °III-IV reactions. High-grade side effects were of dermatologic, cardiovascular, and hematologic nature. A mean treatment delay of 57.5 days (range 23–119) was noted between tumor board recommendation and treatment initiation due to the application process for off-label use in this indication. In conclusion, treatment with regorafenib in relapsed high-grade glioma is a feasible treatment option but has to be considered carefully due to the significant side effect profile.
Adaptation to DNA Damage, an Asymptotic Approach for a Cooperative Non-local System
Authors: Léculier Alexis , Roux Pierre 
Published: June 2022

AbstractFollowing previous works about integro-differential equations of parabolic type modelling the Darwinian evolution of a population, we study a two-population system in the cooperative case. First, we provide a theoretical study of the limit of rare mutations and we prove that the limit is described by a constrained Hamilton-Jacobi equation. This equation is given by an eigenvalue of a matrix which accounts for the diffusion parameters and the coefficients of the system. Then, we focus on a particular application: the understanding of a phenomenon called Adaptation to DNA damage. In this framework, we provide several numerical simulations to illustrate our theoretical results and investigate mathematical and biological questions.
Artificial intelligence and blockchain implementation in supply chains: a pathway to sustainability and data monetisation?
Authors: Tsolakis Naoum , Schumacher Roman , Dora Manoj , Kumar Mukesh 
Published: June 2022

AbstractDigitalisation is expected to transform end-to-end supply chain operations by leveraging the technical capabilities of advanced technology applications. Notwithstanding the operations-wise merits associated with the implementation of digital technologies, individually, their combined effect has been overlooked owing to limited real-world evidence. In this regard, this research explores the joint implementation of Artificial Intelligence (AI) and Blockchain Technology (BCT) in supply chains for extending operations performance boundaries and fostering sustainable development and data monetisation. Specifically, this study empirically studied the tuna fish supply chain in Thailand to identify respective end-to-end operations, observe material and data-handling processes, and envision the implementation of AI and BCT. Therefore, we first mapped the business processes and the system-level interactions to understand the governing material, data, and information flows that could be facilitated through the combined implementation of AI and BCT in the respective supply chain. The mapping results illustrate the central role of AI and BCT in digital supply chains’ management, while the associated sustainability and data monetisation impact depends on the parameters and objectives set by the involved system stakeholders. Afterwards, we proposed a unified framework that captures the key data elements that need to be digitally handled in AI and BCT enabled food supply chains for driving value delivery. Overall, the empirically-driven modelling approach is anticipated to support academics and practitioners’ decision-making in studying and introducing digital interventions toward sustainability and data monetisation.
Optimization of reagent consumption in TEMPO-mediated oxidation of Eucalyptus cellulose to obtain cellulose nanofibers
Authors: Xu Hongyu , Sanchez-Salvador Jose Luis , Balea Ana , Blanco Angeles , Negro Carlos 
Published: June 2022

AbstractEucalyptus cellulose is usually pre-treated by oxidation with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), NaBr and NaClO at pH 10.5 and 25 °C before the mechanical process required to obtain cellulose nanofibers (CNFs). In this study, different aspects to improve the effectiveness and sustainability of the TEMPO-mediated oxidation are analyzed. The optimization was carried out at different reaction times by modifying both the concentration of the NaClO and the amount of the catalysts (TEMPO and NaBr). Results show that the carboxyl groups increased up to 1.1 mmol/g with 5 mmol NaClO/g after 50 min, and that the catalyst concentration can be reduced to 0.025 mmol TEMPO/g and 0.5 mmol NaBr/g to minimize costs while maintaining the high fibrillation degree of the CNFs. The kinetic of the reaction can be considered as zero-order with respect to NaClO, and as first order with respect to cellulose. As a result of this work, the catalyst doses are reduced up to 75% compared to the most widely used catalyst doses (0.1 mmol/g TEMPO and 1 mmol/g NaBr), obtaining highly fibrillated CNFs with a lower environmental impact. This reduction of catalyst doses will reduce the costs and facilitate the implementation of CNF production at industrial scale.Graphical abstract
A comprehensive analysis of the microbiota composition and host driver gene mutations in colorectal cancer
Authors: Yuan Danping , Tao Yong , Wang Haoyi , Wang Jiawei , Cao Yuepeng , Cao Wen , Pan Shou , Yu Zhaonan 
Published: June 2022

AbstractStudies of both, microbiota and target therapy associated with gene mutations in colorectal cancer, (CRC) have attracted increasing attention. However, only a few of them analyzed the combined effects on CRC. we analyzed differences in intestinal microbiota of 44 colorectal cancer patients and 20 healthy controls (HC) using 16S rRNA gene sequencing of fecal samples. For 39 of the CRC patients, targeted Next Generation Sequencing (NGS) was carried out at formalin fixed paraffin embedded (FFPE) samples to identify somatic mutation profiles. Compared to the HC group, the microbial diversity of CRC patients was significantly lower. In the CRC group, we found a microbiome that was significantly enriched for strains of Bifidobacterium, Bacteroides, and Megasphaera whereas in the HC group the abundance of Collinsella, Faecalibacterium, and Agathobacter strains was higher. Among the mutations detected in the CRC group, the APC gene had the highest mutation rate (77%, 30/39). We found that the KRAS mutant type was closely associated with Faecalibacterium, Roseburia, Megamonas, Lachnoclostridium, and Harryflintia. Notably, Spearman correlation analysis showed that KRAS mutations were negatively correlated with the existence of Bifidobacterium and positively correlated with Faecalibacterium. By employing 16S rRNA gene sequencing, we identified more unique features of microbiota profiles in CRC patients. For the first time, our study showed that gene mutations could directly be linked to the microbiota composition of CRC patients. We hypothesize that the effect of a targeted colorectal cancer therapy is also closely related to the colorectal flora, however, this requires further investigation.
Biological Individuality and the Foetus Problem
Authors: Morgan William 
Published: June 2022

AbstractThe Problem of Biological Individuality is the problem of how to count organisms. Whilst counting organisms may seem easy, the biological world is full of difficult cases such as colonial siphonophores and aspen tree groves. One of the main solutions to the Problem of Biological Individuality is the Physiological Approach. Drawing on an argument made by Eric Olson in the personal identity debate, I argue that the Physiological Approach faces a metaphysical problem - the ‘Foetus Problem’. This paper illustrates how metaphysics can contribute to debates about organisms in the philosophy of biology.
Predation impacts brain allometry in female guppies (Poecilia reticulata)
Authors: Vega-Trejo Regina , Vila-Pouca Catarina , Mitchell David J , Kotrschal Alexander 
Published: June 2022

AbstractCognitive and sensory abilities are vital in affecting survival under predation risk, leading to selection on brain anatomy. However, how exactly predation and brain evolution are linked has not yet been resolved, as current empirical evidence is inconclusive. This may be due to predation pressure having different effects across life stages and/or due to confounding factors in ecological comparisons of predation pressure. Here, we used adult guppies (Poecilia reticulata) to experimentally test how direct predation during adulthood would impact the relative brain size and brain anatomy of surviving individuals to examine if predators selectively remove individuals with specific brain morphology. To this end, we compared fish surviving predation to control fish, which were exposed to visual and olfactory predator cues but could not be predated on. We found that predation impacted the relative size of female brains. However, this effect was dependent on body size, as larger female survivors showed relatively larger brains, while smaller survivors showed relatively smaller brains when compared to control females. We found no differences in male relative brain size between survivors and controls, nor for any specific relative brain region sizes for either sex. Our results corroborate the important, yet complex, role of predation as an important driver of variation in brain size.
On the symmetries of Siklos spacetimes
Authors: Calvaruso Giovanni , Kaflou Mahdieh , Zaeim Amirhesam 
Published: June 2022

AbstractWe consider the large class of Siklos spacetimes and investigate their relevant symmetries (homothetic and affine vector fields, Ricci, curvature, Weyl and matter collineations). We prove some general results and obtain complete classifications for homogeneous Siklos spacetimes.
Ti Ions Induce IL-1β Release by Activation of the NLRP3 Inflammasome in a Human Macrophage Cell Line
Authors: Pettersson Mattias , Almlin Sanna , Romanos Georgios E. , Johansson Anders 
Published: June 2022

Abstract
The aim of the present study was to investigate whether titanium (Ti)-induced release of interleukin (IL)-1β acts through the assembly of the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome. In addition, we examined whether particulate Ti or TiO2 activates the same intracellular pathways with the assembly of the NLRP3 inflammasome as Ti ions. Ti ions are known to induce IL-1β maturation and release by the formation of metal–protein aggregates. Wild-type THP-1 (wt.) cells and NLRP3− and ASC− (apoptosis-associated speck-like protein containing caspase recruitment domain (CARD)) knockdown cells were used in the experimental analyses. Macro- and nanoparticles (NPs) of both Ti and TiO2 were used as test agents. IL-1β release as a biomarker for inflammasome activation and cell viability was also analyzed. Periodate-oxidized adenosine triphosphate (oATP) was used to attenuate downstream signaling in NLRP3 inflammasome activation. Cellular uptake of Ti was examined using transmission electron microscopy. Cells exposed to the Ti-ion solution showed a dose-dependent increase in the release of IL-1β; conversely, exposure to particulate Ti did not result in increased IL-1β release. Cell viability was not affected by particulate Ti. Knockdown cells exposed to Ti showed a statistically significant reduction in the release of IL-1β compared with wt. cells (p < 0.001). Cellular uptake was detected in all Ti mixtures, and aggregates with various structures were observed. Ti ion–induced release of bioactive IL-1β in THP-1 cells involves the assembly of the NLRP3 inflammasome.
A novel smartphone app for blood pressure measurement: a proof-of-concept study against an arterial catheter
Authors: Hofmann G. , Proença M. , Degott J. , Bonnier G. , Lemkaddem A. , Lemay M. , Schorer R. , Christen U. , Knebel J.-F. , Schoettker P. 
Published: June 2022

AbstractSmartphones may provide a highly available access to simplified hypertension screening in environments with limited health care resources. Most studies involving smartphone blood pressure (BP) apps have focused on validation in static conditions without taking into account intraindividual BP variations. We report here the first experimental evidence of smartphone-derived BP estimation compared to an arterial catheter in a highly dynamic context such as induction of general anesthesia. We tested a smartphone app (OptiBP) on 121 patients requiring general anesthesia and invasive BP monitoring. For each patient, ten 1-min segments aligned in time with ten smartphone recordings were extracted from the continuous invasive BP. A total of 1152 recordings from 119 patients were analyzed. After exclusion of 2 subjects and rejection of 565 recordings due to BP estimation not generated by the app, we retained 565 recordings from 109 patients (acceptance rate 51.1%). Concordance rate (CR) and angular CR demonstrated values of more than 90% for systolic (SBP), diastolic (DBP) and mean (MBP) BP. Error grid analysis showed that 98% of measurement pairs were in no- or low-risk zones for SBP and MBP, of which more than 89% in the no-risk zone. Evaluation of accuracy and precision [bias ± standard deviation (95% limits of agreement)] between the app and the invasive BP was 0.0 ± 7.5 mmHg [− 14.9, 14.8], 0.1 ± 2.9 mmHg [− 5.5, 5.7], and 0.1 ± 4.2 mmHg [− 8.3, 8.4] for SBP, DBP and MBP respectively. To the best of our knowledge, this is the first time a smartphone app was compared to an invasive BP reference. Its trending ability was investigated in highly dynamic conditions, demonstrating high concordance and accuracy. Our study could lead the way for mobile devices to leverage the measurement of BP and management of hypertension.
On maximum-sum matchings of points
Authors: Bereg Sergey , Chacón-Rivera Oscar P. , Flores-Peñaloza David , Huemer Clemens , Pérez-Lantero Pablo , Seara Carlos 
Published: June 2022

AbstractHuemer et al. (Discrete Mathematics, 2019) proved that for any two point sets R and B with $$|R|=|B|$$

|
R
|
=
|
B
|

, the perfect matching that matches points of R with points of B, and maximizes the total squared Euclidean distance of the matched pairs, has the property that all the disks induced by the matching have a common point. Each pair of matched points $$p\in R$$

p
∈
R

and $$q\in B$$

q
∈
B

induces the disk of smallest diameter that covers p and q. Following this research line, in this paper we consider the perfect matching that maximizes the total Euclidean distance. First, we prove that this new matching for R and B does not always ensure the common intersection property of the disks. Second, we extend the study of this new matching for sets of 2n uncolored points in the plane, where a matching is just a partition of the points into n pairs. As the main result, we prove that in this case all disks of the matching do have a common point.
Flame retardancy of PET foams manufactured from bottle waste
Authors: Bocz Katalin , Ronkay Ferenc , Vadas Dániel , Molnár Béla , Gere Dániel , Czigány Tibor , Marosi György 
Published: June 2022

AbstractSupercritical CO2-assisted extrusion technique was used to produce flame retarded foams from recycled poly(ethylene terephthalate) (rPET). Synergistic combination of aluminium-alkylphosphinate flame retardant (FR) and natural montmorillonite (MMT) was utilised to provide adequate flame retardancy at moderate loadings, i.e. with less than 9% of additives. Addition of FR was found to increase the rate of degradation during production (compounding and foam extrusion), which was effectively compensated by chain extender (CE) addition that ensured the melt strength required to obtain proper foam structure. The effects of the FR content and the CE addition on the viscosity of the rPET compounds and on the morphological, thermal, flammability and mechanical properties of the foam products were comprehensively investigated. When compared to injection moulded bulk materials of identical compositions, the highly porous structure of foams was found to increase flammability according to UL94 tests and LOI measurements but has not been shown to be detrimental to heat release rates as measured by cone calorimetry. It was concluded that with well-balanced composition, i.e. 8% FR + 1% MMT + 1% CE, low-density foams (with porosities higher than 70%) of uniform microcellular structure and prominent flame retardant characteristics (such as V0 rating according to UL94 standard, LOI of 28.5% and by 50% reduced peak of heat release rate and by 30% reduced total heat emission) can be manufactured even from rPET.
A mechanism explaining the metamorphoses of KAM islands in nonhyperbolic chaotic scattering
Authors: Nieto Alexandre R. , Seoane Jesús M. , Barrio Roberto , Sanjuán Miguel A. F. 
Published: June 2022

AbstractIn the context of nonhyperbolic chaotic scattering, it has been shown that the evolution of the KAM islands exhibits four abrupt metamorphoses that strongly affect the predictability of Hamiltonian systems. It has been suggested that these metamorphoses are related to significant changes in the structure of the KAM islands. However, previous research has not provided an explanation of the mechanisms underlying the metamorphoses. Here, we show that they occur due to the formation of a homoclinic or heteroclinic tangle that breaks the internal structure of the main KAM island. We obtain similar qualitative results in a two-dimensional Hamiltonian system and a two-dimensional area-preserving map. The equivalence of the results obtained in both systems suggests that the same four metamorphoses play an important role in conservative systems.
The MOBIS dataset: a large GPS dataset of mobility behaviour in Switzerland
Authors: Molloy Joseph , Castro Alberto , Götschi Thomas , Schoeman Beaumont , Tchervenkov Christopher , Tomic Uros , Hintermann Beat , Axhausen Kay W. 
Published: June 2022

AbstractThis article presents the MOBIS dataset and underlying survey methods used in its collection. The MOBIS study was a nation-wide randomised controlled trial (RCT) of transport pricing in Switzerland, utilising a combination of postal recruitment, online surveys, and GPS tracking. 21,571 persons completed the first online survey, and 3680 persons completed 8 weeks of GPS tracking. Many continued tracking for over a year after the study was completed. In the field experiment, participants participated through the use of a GPS tracking app, Catch-my-Day, which logged their daily travel on different transport modes and imputed the trip segments and modes. The experiment lasted 8 weeks, bookended by two online surveys. After the first 4-week control phase, participants were split into two different treatment groups and a continued control group. An analysis of the survey participation shows that the technology is capable of supporting such an experiment on both Android and iOS, the two main mobile platforms. Significant differences in the engagement and attrition were observed between iOS and Android participants over the 8-week period. Finally, the attrition rate did not vary between treatment groups. This paper also reports on the wealth of data that are being made available for further research, which includes over 3 million trip stages and activities, labelled with transport mode and purpose respectively.