bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of concept and mechanism study.
Authors: Al-Hakeim Hussein Kadhem , Al-Rubaye Haneen Tahseen , Al-Hadrawi Dhurgham Shihab , Almulla Abbas F. , Maes Michael 
Published: May 2022

Abstract
The immune-inflammatory response during the acute phase of COVID-19, as assessed using peak body temperature (PBT) and peripheral oxygen saturation (SpO2), predicts the severity of chronic fatigue, depression and anxiety (“physio-affective”) symptoms three to four months later. The present study was performed to characterize whether the effects of SpO2 and PBT on the physio-affective phenome of Long COVID are mediated by immune, oxidative and nitrosative stress (IO&NS) pathways. This study assayed SpO2 and PBT during acute COVID-19, and C-reactive protein (CRP), malondialdehyde (MDA), protein carbonyls (PCs), myeloperoxidase (MPO), nitric oxide (NO), zinc, and glutathione peroxidase (Gpx) in 120 Long COVID individuals and 36 controls. Cluster analysis showed that 31.7% of the Long COVID patients had severe abnormalities in SpO2, body temperature, increased oxidative toxicity (OSTOX) and lowered antioxidant defenses (ANTIOX), and increased total Hamilton Depression (HAMD) and Anxiety (HAMA) and Fibromylagia-Fatigue (FF) scores. Around 60% of the variance in the physio-affective phenome of Long COVID (a factor extracted from HAMD, HAMA and FF scores) was explained by OSTOX/ANTIOX ratio, PBT and SpO2. Increased PBT predicted increased CRP and lowered ANTIOX and zinc levels, while lowered SpO2 predicted lowered Gpx and increased NO production. Both PBT and SpO2 strongly predict OSTOX/ATIOX during Long COVID. In conclusion, the impact of acute COVID-19 on the physio-affective symptoms of Long COVID is partly mediated by OSTOX/ANTIOX, especially lowered Gpx and zinc, increased MPO and NO production and lipid peroxidation-associated aldehyde formation. Post-viral physio-affective symptoms have an inflammatory origin and are partly mediated by neuro-oxidative toxicity.
Bio-Water Management Mechanisms to Inspire New Building Solutions.
Authors: tantawy amal 
Published: May 2022

Abstract
This research paper contributes to investigating the extent to which knowledge and mechanisms of biological water management can be explored to inspire new solutions for buildings and how biologically developed methods that can be used both to provide water and obtain it from the outer casings of buildings interacting with nature can be explored, and the research methodology is first carried out by examining various examples of organisms that have highlighted and demonstrated their natural success in the good management of For the water and work of a detailed analysis of the mechanisms of these organisms in the provision and management of water, ii detailed presentation and analysis of a set of global examples simulated to the environment, which has a precedent in the application of the concept (water management through an environmentally adapted outer shell), thirdly comes the applied study by proposing checklist models with proposed relative weights based on previous studies to measure the success of analytical examples in accomplishing the task of Namibia Hydrology Center ranked first with the highest percentage of use of naturally inspired water management functions, Namibia Hydrology Center ranked first with the highest percentage of use of naturally inspired water management functions, and the first (water collection) job was ranked first with the highest percentage of repetition in all study cases, while the job (water storage) was second with a percentage of 63% of repetition, and reached 100% of repetition in all study cases, while the job (water storage) was second with a percentage of 63% of repetition. The element (water collection) in the first place with the highest percentage reached 36% for the total size of all other elements of water functions, while the element (water storage) in the second place reached the highest percentage reached 23% relative to the total size of all elements of other aquatic functions, and the research reached many conclusions such as that the strategies of balance and biological water management in organisms in nature to provide innovative solutions for the design of the exterior of the building, especially in the third world countries new to this type of building where water management strategies are transferred from nature to the architectural design of the covers of external buildings, taking into account the choice of natural strategies suitable for each environment and place, as well as the research study reached that the strategies of living organisms in water management, whether synthetic or behavioral adaptation, boils down to a set of key biological functions, namely (acquisition of water - water transfer - storage of water- storage Water - preventing water loss - water purification).
Blueberry improves components of metabolic syndrome in animal studies: a systematic review and meta-analysis
Authors: Azari Hushyar , Morovati Ashti , Gargari Bahram Pourghassem , Sarbakhsh Parvin 
Published: May 2022

Abstract

Metabolic syndrome (MetS) is the co-occurrence of several interconnected metabolic disorders and its prevalence is rising in the world. We hypothesized that blueberry (BB) feeding will have positive effects on components of MetS according to studies which used animal subjects. A systematic search for the studies in Science Direct, Embase, Cochrane and PubMed databases was done. The Studies which investigated effects of BB on components of MetS in animal models were included. Of 1030 potentially relevant studies, after investigation, 28 animal studies remained for further investigation. Of these, 1 study was conducted using pigs, one study using hamsters, 15 studies using mice and 11 studies using rats. 18 studies were eligible for the meta-analysis, and others were included in systematic review. The meta-analysis was done by Comprehensive Meta-analysis Software.The results of the meta-analysis demonstrated no significant effect of blueberry feeding on body weight [p = 0.65 CI95%: (-3.029, 1.892)]. However, a statistically significant improvement of systolic blood pressure [p < 0.001, CI95%: (-0.916, -0.283)], diastolic blood pressure[p = 0.01, CI95%: (-1.10, -0.13)], triglycerides[p = 0.01, CI95%: (-1.018, -0.109], total cholesterol [p < 0.001 CI95%: (-1.693, -0.782)], low density lipoprotein(LDL) [p = 0.008, CI95%: (-2.182, -0.334)], high density lipoprotein(HDL) [p = 0.02, CI95%: (0.077, 1.057)], blood glucose [p < 0.001, CI95%:( -1.638, -0.623)] and insulin level [p < 0.001, CI95%: (-1.711, -0.688)] was reported. Conclusion: this study showed that blueberry can be effective in ameliorating some components of metabolic syndrome in animal models. There is a need to conduct more studies on this subject in humans.
Ensuring Food Security of Smallholder Farmers through Improving Productivity and Nutrition of Potato
Authors: Moreda Gedefa , Haile Ashenafi 
Published: May 2022

Abstract
In a time of extremely high population growth, loss of arable land and climate change effects, food security issue is becoming more and more important. Thus, improving the food security of smallholder farmer is a major concern particularly in developing country. In this regard potato is one of the important cash crops which contributes for food security and reduce poverty among smallholder farmers in the developing countries like Ethiopia. However, the productivity of the crops is constrained by the limitation of soil macronutrient. Therefore, this research was conducted with the aim to improve potato productivity through intensive and economical uses of soil macronutrients. A factorial combination of four soil macro nutrients and three potato varieties were used in a Randomized Complete Block Design with three replications. The result revealed that soil macronutrients and potato variety had significantly influenced on phenology and growth components. Interaction effects of soil macro-nutrients and variety had also significantly affected total and marketable tuber yield of potato. The marginal rate of return of 7,370% was obtained from the Wabi variety with the application of 200 kg ha − 1 soil macro-nutrients (NPS fertilizer). Therefore, growing the Wabi variety of potato at 200 kg/ha of soil macro-nutrients resulted in a high productivity and economic returns of the crop.
Lysine methylation promotes NFAT5 activation upon EGFR activation and predicts the efficacy of temozolomide
Authors: Wang Yuhong , Li Yatian , Zhang Binbin , Gao Zhenyue , Hu Ruxin , Wang Yuqing , Liu Chao , Zhang Xuebin , Yang Jingxuan , Mei Mei , Ren Yu , Li Min , Zhou Xuan 
Published: May 2022

Abstract
Temozolomide (TMZ) therapy exert limited clinical benefits in glioblastoma multiforme (GBM) patients with high EGFR activity, underscoring the need for effective combination therapy. Here, we show that tonicity-responsive enhancer binding protein (NFAT5) lysine methylation, is a determinant of TMZ response. Mechanistically, EGFR activation induces phosphorylated EZH2 (Ser21) binds to and triggers NFAT5 methylation at K668. Methylation prevents NFAT5 cytoplasm interaction with E3 ligase TRAF6, thus blocks TRAF6 induced K63-linked ubiquitination mediated NFAT5 lysosomal degradation and cytosol localization restriction, result in NFAT5 protein stabilization, nuclear accumulation and activation. Methylated NFAT5 leads to the upregulation of ITGB1, a transcriptional target of NFAT5, which is responsible for unfavorable TMZ response. Inhibition of NFAT5 K668 methylation improved TMZ efficacy in vivo. Notably, NFAT5 K668 methylation levels are elevated in TMZ-refractory specimens and confer poor prognosis. Our findings suggest targeting NFAT5 methylation as an effective therapeutic strategy to improve TMZ response in tumors with EGFR activation.
Understanding of India’s History in Social Philosophy of Rabindranath Tagore
Authors: Скороходова Т.Г. 
Published: May 2022

На основе анализа философских трудов Рабиндраната Тагора в статье представлена реконструкция его понимания процессов и смыслов истории Индии. Подход к истории родной страны задан стремлением Тагора раскрыть её действительное содержание в сопоставлении с другими странами и цивилизациями. Антропологически ключевой историософской идеей Тагора является мысль о человеческой свободе, воплощающейся в истории цивилизации во множестве измерений; отсюда его понимание истории как устремленности в будущее. Тагор создал особую «философию индийской истории» как истории её социальной жизни, духа и культуры. В основе его общего понимания истории страны лежит идея «Большой Индии» – древней цивилизации с выдающейся способностью объединять все народы и разрешать конфликты. Цель и идеал заключаются в её стремлении к гармоническому «единству в многообразии» в истории, а политическая и экономическая эволюция составляет её фон. Культурная и духовная жизнь в этой философии полагаются главным наследием и перспективой развития Индии.
Based on analysis of philosophical works by Rabindranath Tagore, the article presents a reconstruction of his understanding of meanings and processes of India’s history. Tagore’s approach to native history is determined his striving for discovery of its real content in juxtaposition with other countries and civilizations. Anthropologically, the key historiosophical idea by Tagore is an idea of human freedom embodied in history of civilizations in many aspects, therefore, he understands history as an orientation for future. Tagore had created special philosophy of Indian history as history of her social life, spirit and culture. The general understanding of India’s history by R. Tagore had united idea of ‘Greater India’ – ancient civilization with outstanding ability to integrate all peoples and to resolve conflicts, as well as ideas of striving to harmonic ‘unity in diversity’ in history as its goal and ideal, of political and economic evolution as the background. Cultural and spiritual life ground main heritage and perspective of development of India.
Pavel Grigorievich Mizhuev in the Communicative Space of N. I. Kareev
Authors: Чикалова И.Р. 
Published: May 2022

Автор реконструирует коммуникативные связи между двумя историками – Павлом Григорьевичем Мижуевым и Николаем Ивановичем Кареевым. Мижуев, ученый второго ряда на фоне мэтра, не являвшийся полноправным членом профессиональной корпорации дореволюционных историков, вошел в нее в качестве преподавателя трех факультетов Петроградского университета после Революции. Мижуев был последователем умеренно-либеральной и позитивистской школы Кареева, еще в дореволюционный период создавший цельную картину разных сторон жизни Великобритании и доминионов в их исторической динамике, колониальной политики Англии, издавший первую в России историю США, Канады, Австралии и Новой Зеландии. И хотя имя Мижуева не появляется в воспоминаниях Кареева, он, хоть и скромно, но присутствовал в его коммуникативном пространстве, например, приняв участие в проектах, которые курировал Кареев, – в серии книг «История Европы по эпохам и странам в Средние века и Новое время», в «Новом энциклопедическом словаре» Брокгауза и Ефрона, а также публикуясь с ним в одних изданиях и работая в течение пяти лет на одной кафедре и факультете.
The author reconstructs the communication links between two historians – Pavel Grigori-evich Mizuev and Nikolai Ivanovich Kareev. Mizhuev, a second-tier scientist against the background of the master, who was not a full-fledged member of the professional corporation of pre-revolutionary historians, entered it as a teacher in three faculties of Petrograd University after the Revolution. Mizhuev was a follower of the moderately liberal and positivist school of Kareev, who back in the pre-revolutionary period created an integral picture of different aspects of the life of Great Britain and the dominions in their historical dynamics, the colonial policy of England, and published the first history of the USA, Canada, Australia and New Zealand in Russia. And although the name of Mizuev does not appear in Kareev's memoirs, he, albeit modestly, was present in his communicative space, for example, taking part in projects supervised by Kareev, in the series of books «History of Europe by Era and Countries in the Middle Ages and New time» in the «New Encyclopedic Dictionary» of Brockhaus and Efron, as well as publishing with him in the same editions and working for five years at the same department and faculty.
The New Story of the Word / A New Word in History: Forensic
Authors: Еремеева С.А. 
Published: May 2022

Forensic turn остался невидимым для российских гуманитарных исследований. Можно предположить наличие внешних и внутренних причин для этого. Первые – политические: подобные исследования не приветствуются государством. Вторые – академические: такие исследования выходят за привычные рамки гуманитарных на-ук. Они предполагают сотрудничество исследователей с активистами, журналистами, художниками. Примеров реализации такого опыта у нас нет. Тем не менее запрос на подобный подход существует, и, возможно, он будет реализован позднее.
The forensic turn went unnoticed in Russian humanitarian studies. It can be assumed that there are both external and internal reasons for this. The former is political: such studies are not approved of by the authorities now. The latter is academic: such studies go beyond the frames of habitual humanities research. It presupposes collaboration of researchers with activists, journalists and artists. We have no examples of such experience. Nevertheless, there is a request for the approach, and it is possible that it will be implemented in the future in Russia.
Health Risk Factors and Refugee Children in Bangladesh
Authors: Parvin Nusrat 
Published: May 2022

In the Cox's Bazar refugee camps, around 855,000 Rohingya people live, with 54 percent of them being children. In Myanmar, these children were denied access to adequate healthcare, immunizations, food & nutrition, hygiene, and education. Since August 2017, when the Rohingya were forced to flee from Myanmar to Bangladesh due to the Myanmar military's brutality, they have become more vulnerable. Children were vulnerable to hunger and various infectious diseases as a result of the fighting and displacement, which posed serious health hazards. The numerous health risk factors of the children were analyzed in this study in order to provide a picture of the refugee camp.
Method: In December 2017, a questionnaire was used to assess the shelter and camp environment, food and nutrition, WASH knowledge and practice, vaccination and immunisation, medication and supplements, and education of 120 parents of Kutupalong camp no 4, OO zone.
Result: The health of 29% of the children was better than a year before, while 68 percent of the children had the same result as the previous year. Breakfast and supper were consumed by 96.67 percent of the children, and 80.8 percent were fed three times lunch and supper, with 63 percent agreeing that the camp setting was not ideal for their growth. 61 percent of families could provide enough water for their children using the water containers provided by various NGOs (Non-governmental Organisations). Despite the fact that the water sources are not close to their homes, 98.3 percent of families use tube well water. Only 49.2 percent of parents said the latrines had enough water for bathing and cleaning, while 29.2 percent said they had adequate lighting and were in their suitable placements. After using the restroom, 66.7 percent of children used soap, 16.7% used soil or ashes, and the rest used nothing. Vaccinations had been given to 91.7 percent of Rohingya children. In Bangladeshi refugee camps, 56.2 percent of Rohingya children were educated by learning centers run by various NGOs and Maktabs (Muslim kids were taught Quran in masjids).
Limitations: This report has relatively limited data that does not provide a comprehensive picture of the children's camp situation.
Conclusion: Based on the findings of the study, the camp's status may be improved if the children and their families were given good WASH knowledge and introduced to the WASH awareness programme, proper water supply and sanitation, and health care as needed.
Research on Government Regulation of Social Credit System — From the Perspective of Business Ethics
Authors: Li Zhi-qiang 
Published: May 2022

Institution system is an important part of modern social governance. Government, market and social relations within the system, as well as the corresponding institutional arrangements, can be said to be the top priority. Corporate social responsibility is an outstanding case that embodies the relationship and institutional arrangement of the three in practice.Government regulation of social credit system is a good example to analysis it. The research on government regulation of social credit system itself is put forward from the perspective of government, so in the field of government regulation of social credit system, should enterprises play a role? Especially in the era of big data, a large number of data are provided by private enterprises. Without these data, it is difficult to complete the construction of big data system. If enterprises should play their role, what’s the contribution of the government? Academic and industrial circles have been expressing their own opinions on these issues.Therefore, this paper attempts to build a game model among government, enterprise and society to solve the following problems: how to solve the relationship problem among government, enterprise and society? How to build the corresponding system? What’s the corresponding government regulation of China’s social credit system go from the perspective of business ethics?Through the game model analysis, the author finds that shareholders can reduce the threat of CEO replacement and collude with the management staff members to make the cake (including the interests of stakeholders) smaller. But on the basis of the loss of stakeholders’ rights and interests, shareholders’ wealth is increasing, which also explains why more and more senior executives are trying to form collusion with stakeholders in the campaign against antitakeover and loose audit system. Shareholders’ rights and interests and stakeholders’ rights and interests present a seesaw phenomenon. The response of the stakeholders and shareholders to a better corporate governance model is consistent. That is to say, the increase of shareholders’ income is not necessarily based on the loss of stakeholders. The game model also shows that the protection of formal laws and regulations is the main factor to increase the benefits of stakeholders. Through the case of the social credit system, we will conclude that the formal laws and regulations cannot fully ensure the increase of stakeholders’ income, but also need to strengthen the transformation of institutional advantages into governance advantages, and strengthen the law enforcement. It will finally promote the further improvement of social credit system.
Indirect and Direct Effects of SARS-CoV-2 on Human Pancreatic Islets
Authors: Nasr Moufida Ben , D’Addio Francesca , Montefusco Laura , Usuelli Vera , Loretelli Cristian , Rossi Antonio , Pastore Ida , Abdelsalam Ahmed , Maestroni Anna , Dell’Acqua Marco , Ippolito Elio , Assi Emma , Seelam Andy Joe , Fiorina Roberta Maria , Chebat Enrica , Morpurgo Paola , Lunati Maria Elena , Bolla Andrea Mario , Abdi Reza , Bonventre Joseph V. , Rusconi Stefano , Riva Agostino , Corradi Domenico , Santus Pierachille , Clark Pamela , Nebuloni Manuela , Baldi Gabriella , Finzi Giovanna , Folli Franco , Zuccotti Gian Vincenzo , Galli Massimo , Herold Kevan C. , Fiorina Paolo 
Published: May 2022

<p>Recent studies have shown that SARS-CoV-2 infection may induce metabolic distress, leading to hyperglycemia in patients affected by COVID-19. We investigated the potential indirect and direct effects of SARS-CoV-2 on human pancreatic islets in 10 patients who became hyperglycemic after COVID-19. While there was no evidence of peripheral anti-islet autoimmunity, the serum of these patients displayed toxicity on human pancreatic islets, which can be abrogated by the use of anti-IL1b, anti-IL-6 and anti-TNF-a, cytokines known to be highly upregulated during COVID-19. Interestingly, the receptors of those aforementioned cytokines were highly expressed on human pancreatic islets. An increase in peripheral unmethylated <em>INS</em> DNA, a marker of cell death, was evident in several patients with COVID-19. Pathology of the pancreas from deceased hyperglycemic patients who had COVID-19, revealed mild lymphocytic infiltration of pancreatic islets and pancreatic lymph nodes. Moreover, SARS-CoV-2-specific viral RNA, along with the presence of several immature insulin granules or proinsulin, were detected in post-mortem pancreatic tissues, suggestive of β-cell altered proinsulin processing, as well as β-cell degeneration and hyperstimulation. These data demonstrate that SARS-CoV-2 may negatively affect human pancreatic islets function and survival by creating inflammatory conditions and possibly with a direct tropism, which may in turn lead to metabolic abnormalities observed in patients with COVID-19. </p>