bluuebunny/crossref_metadata_2025_split huggingface dataset:
A relação entre a aderência dos relatos integrados ao framework do IIRC e o desempenho econômico
Authors: Romão Gabriel , Ribeiro Cíntia de Melo de Albuquerque , Neto Julio Vieira 
Published: July 2022

Objetivo: Analisar a aderência dos Relatos Integrados (RIs) de uma amostra composta por três empresas brasileiras ao Framework do IIRC (International Integrated Reporting Council) e compreender a contribuição do nível de qualidade desses relatórios para o desempenho econômico das empresas adotantes.
Metodologia: As empresas foram selecionadas no banco de dados do IIRC. Utilizando como referência o método apresentado por Kiliç e Kuzey (2018), foi adaptado um modelo de ID (Índice de Divulgação), através da técnica de análise de conteúdo, para mensurar o nível de aderência dos Relatos ao Framework. Após o cálculo dos IDs, foram analisados o Coeficiente de Variação (CV) de índices de liquidez e solvência das empresas e o desempenho macroeconômico do período pesquisado, objetivando constatar se os RIs aderentes ao Framework estão associados ao desempenho econômico das empresas.
Resultados: Os resultados da análise apontam que não é possível afirmar que elevados níveis de aderência ao Framework estão associados ao desempenho econômico das empresas, haja vista que o cálculo do CV dos índices financeiros, durante o período de publicações dos RIs, não apresenta uma dispersão menor quando comparados ao período anterior a tais publicações
Contribuição do estudo: As pesquisas recentes a respeito do tema Relato Integrado não apresentam uma relação entre a aderência das publicações ao Framework do IIRC e o desempenho econômico de empresas brasileiras. Desse modo, este estudo demonstra-se relevante ao pesquisar o conteúdo dos Relatos Integrados publicados por empresas brasileiras e o relacionamento dessas informações com o desempenho econômico, verificando se os Relatos Integrados cumprem a promessa de entregar benefícios econômicos aos adotantes do modelo.
Role of Drug Delivery System in Improving the Bioavailability of Resveratrol
Authors: Saleem Zonish , Rehman Kanwal , Hamid Akash Muhammad Sajid 
Published: July 2022

Abstract:
Resveratrol (RSV) is known as a natural polyphenolic compound that is known for its therapeutic activities but has limited bioavailability. The aim of our study was to explore various drug-delivering methods that are being employed to achieve target-oriented delivery and therapeutic performance of RSV. To improve the bioavailability and pharmacokinetic properties of RSV, efforts are being made by producing efficient formulations accompanying efficient drug delivery strategies. Several clinical trial studies have been conducted on RSV isomers, and the majority of studies indicated that trans-RSV had better clinical potential and therapeutic effectiveness in various types of complications such as colorectal cancer, metabolic syndrome, hypertension, obesity, neurodegenerative diseases, diabetes, hepatic disease, cardiac disorders, and breast cancer. However, multiple research studies enable us to understand various strategies that can enhance the systemic availability and efficacy of topical RSV formulations. In this article, we emphasize the hurdles of RSV delivery processes. We summarized that for delivering liquid and solid microparticles of RSV, the micro-particulate system works efficiently. Another technique in which particles are enclosed by a coating is called microencapsulation. This technique reduces the degradation of pharmaceutical compounds. Similarly, the cyclodextrin system is mainly used for poorly soluble drugs. On the other hand, the vesicular system is another micro-particulate system that can encapsulate hydrophilic and hydrophobic drugs. However, the RSV nanosponge formulations have advanced nanodrug delivery systems also make it possible to use RSV for its antioxidant potential.
Redox Interactions in Chemo/Radiation Therapy-induced Lung Toxicity; Mechanisms and Therapy Perspectives
Authors: Lai Xixi , Najafi Masoud 
Published: July 2022

Abstract:
Lung toxicity is a key limiting factor for cancer therapy, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy may also induce lung pneumonitis and fibro-sis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water mole-cules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells and some nonimmune cells such as fi-broblasts and endothelial cells. There are several ROS generating enzymes within lung tissue. NADPH Oxidase enzymes, cyclooxygenase-2 (COX-2), dual oxidases (DUOX1 and DUOX2), and the cellular respiratory system in the mitochondria are the main sources of ROS production follow-ing exposure of the lung to anticancer agents. Furthermore, inducible nitric oxide synthase (iNOS) has a key role in the generation of NO following radiotherapy or chemotherapy. Continuous genera-tion of ROS and NO by endothelial cells, fibroblasts, macrophages, and lymphocytes causes apop-tosis, necrosis, and senescence, which lead to the release of inflammatory and pro-fibrosis cyto-kines. This review discusses the cellular and molecular mechanisms of redox-induced lung injury following cancer therapy and proposes some targets and perspectives to alleviate lung toxicity.
Maternal and Placental Risk Factors for Small Gestational Age and Fetal
Malnutrition
Authors: Natarajan Vivekanand , Singh Poonam , Vigneshwar Nattankali Kannappa Venkatesan , Anthony Michael Leonard , Rao Shalinee , Chacham Swathi , Chaturvedi Jaya , Basu Sriparna 
Published: July 2022

Aim:
This case-control study was conducted to identify maternal and placental risk fac-tors of small-for-gestational-age (SGA) and fetal malnutrition.

Methods:
Cases comprised 104 consecutively delivered SGA neonates (determined as per INTER-GROWTH-21st standard). An equal number of next-born gestation and gender-matched appropriate-for-gestational age (AGA) neonates served as controls. Maternal risk factors were enquired, and placentae were evaluated by clinical and histopathological examination. Nutrition of the neonates was assessed by the clinical assessment of nutrition (CAN) score. Univariate and multivariate lo-gistic regression analysis was done to identify the maternal and placental risk factors.

Results:
The prevalence of SGA in the present study was 23.9%. Maternal fever [adjusted Odds Ra-tio (aOR), 95% confidence interval (CI), 16.3 (3.5-124.1); p = 0.001], presence of placental syncyt-ial knots [aOR (95% CI), 2.9 (1.1-9.1); p = 0.04] and placental calcifications [aOR (95% CI), 3(1.1-8.7); p = 0.03], were identified as independent predictors of SGA using multivariate logistic regres-sion analysis. Malnutrition (SCORE <25) affected 64% of SGA and 16.3% of AGA neonates. The only risk factor significantly associated with malnourished SGA was prematurity, whereas malnour-ished AGA was significantly associated with prematurity and fetal distress. In-hospital morbidities significantly higher in SGA were perinatal asphyxia, respiratory distress, need for respiratory sup-port, polycythemia, hypoglycemia, and feeding intolerance. Mortality before discharge was 4.8% and 3.8% in SGA and AGA population, respectively (p > 0.05). Neonatal outcomes were compara-ble among well-nourished, malnourished SGA and AGA groups.

Conclusions:
Maternal fever, placental syncytial knots, and calcifications were independent risk fac-tors of SGA, whereas prematurity and fetal distress were responsible for malnutrition.
A Mini-Review on Simultaneous Quantification of Active Pharmaceutical Ingredients By UV and Quality by Design Assisted HPLC Method
Authors: Rajput Geeta , Patel Preeti , Gupta Ghanshyam Das , Kurmi Balak Das 
Published: July 2022

Objective:
Nowadays, most pharmaceutical formulations contain more than one drug because
there are numerous advantages to multicomponent formulations, like patient compliance, enhanced efficacy,
synergetic effects of both drugs, etc. This review paper describes the simultaneous estimation methods
such as UV spectroscopy and high-performance liquid chromatography (HPLC) to determine various
drug molecules and active pharmaceutical ingredients (APIs). In addition, the implementation of the quality
by design (QbD) principle is used to illustrate how these approaches can be developed and validated.

Method:
To estimate the drug content in these multicomponent formulations, several UV spectroscopy
and HPLC methods have been developed and validated as per the available literature. UV spectrophotometry
and HPLC are among the most critical tools in the analysis of drugs in pharmaceutical formulations.
The QbD based optimization approach applies to developing the simultaneous estimation method, which
could be designed with predefined objectives, that emphasize the product and process to maintain the
desired quality. The QbD approach followed the guidelines mentioned in ICH Q8 (R2).

Results:
This review article gives brief information regarding the various QbD optimized UV and HPLC
methods for simultaneous estimation of multicomponent formulations and their recent applications and
elaborates on multiple steps in the development of the HPLC method along with their applications.

Conclusion:
The available information is very informative for multicomponent analysis, and it will open
new paradigms in upcoming research in the field of analysis.
Carvacrol as a Prospective Regulator of Cancer Targets/Signalling Pathways
Authors: Singh Jyoti , Luqman Suaib , Meena Abha 
Published: July 2022

Background:
Carvacrol is a naturally occurring phenolic isopropyl monoterpene isolated from oregano, thyme, pepperwort, ajwain, marjoram, and wild bergamot. It possesses pharmacological activities, including anticancer, anti-genotoxic, and anti-inflammation associated with antioxidant properties. The antioxidant property of carvacrol is found to be accountable for its anticancer property. Thus, the present review summarizes and discusses the anticancer potential of carvacrol, revealing its target, signalling pathways, efficacy, pharmacokinetics, and toxicity.

Objective:
Carvacrol showed promising activity to be considered in more detail for cancer treatment. This review aimed to summarize the evidence concerning understanding the anticancer potential of carvacrol. However, the mode of action of carvacrol is not yet fully explored and hence requires detailed exploratory studies. This review consists of carvacol’s in vitro, in vivo, preclinical and clinical studies.

Method:
A literature search was done by searching various online databases like Pubmed, Scopus, and Google Scholar with the specific keyword “Carvacrol,” along with other keywords such as “Antioxidant properties,” “oncology research,” “genotoxicity,” and “anti-inflammatory property.”

Results:
Carvacrol possesses weak mutagenic and genotoxic potential at nontoxic doses. Carvacrol alone shows the potential to target cancerous cells and significantly deter the growth of cancer cells; this is a targeted method. It offers anti-inflammatory effects by decreasing oxidative stress, which primarily targets ER and mitochondria. Carvacrol depicts targeted explicitly ROS-dependent and mitochondrial-mediated apoptosis in different cancer cells. Moreover, carvacrol significantly regulates the cell cycle and prevents tumor progression. Few reports also suggest its a significant role in inhibiting cell migration, invasion, and angiogenesis in tumor cells. Hence, carvacrol affects cell survival and cell-killing activity by targeting key biomarkers and major signalling pathways, including PI3K/AKT/mTOR, MAPK, STAT3, and Notch.

Conclusion:
Until now, its anticancer mechanism is not yet fully explored. A limited number of research studies have been done on carvacrol instead of possessing promising anti-cancer potential. It possesses both cancer prevention and cancer therapeutic properties. This molecule needs more validatory research so that it could be analyzed precisely and sensibly
The Effect of Skin-to-Skin Contact Between Father and Baby on Paternal Attachment
Authors: Korukcu Oznur , Yilmaz Mine Erdoğan , Kabukcuoglu Kamile 
Published: July 2022

Aim:
This study aims to determine the effect of skin-to-skin contact between father and baby within the first three hours following the childbirth on the level of paternal attachment.

Methods:
Data were collected from 69 fathers between May-July 2018 with Paternal Infant Attachment Scale in Antalya Medical Park Hospital in Turkey in this quasi-experimental study.

Results:
Total score of the fathers who established skin-to-skin contact with the babies was 82.34±7.76, and that of the control group was 66.07±18.2 (p<0.05). Moreover, the paternal-infant attachment level of the fathers in the study group who became fathers for the first time was higher than that of the control group.

Conclusion:
The skin-to-skin contact between father and baby following childbirth was an effective practice in the transition to fatherhood.
Innovation in the Treatment of Persistent Pain in Adults With NF1: Implementation of the iCanCope Mobile App
Authors: Shaker Jake , Buono Frank , Lalloo Chitra , Stinson Jennifer , Grau Lauretta , Zempsky William , Larkin Kaitlyn 
Published: July 2022

Background
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic condition affecting 1 in 2500 individuals. Over 50% of individuals with NF1 report significant pain and discomfort, which may be associated with benign and malignant tumors, but is often not localized to a structural lesion, thus presenting treatment challenges for patients and their medical caregivers. To date, there are very few treatments aside from surgical intervention to mitigate pain.

Objective
We developed the iCanCope-NF mobile app for pain self-management. iCanCope-NF is a customized self-monitoring and pain management mobile app designed to provide resources and support for those having chronic pain due to NF1. The app enables users to access daily pain monitoring and quality of life check-ins, allows them to plot interrelated variables on various timelines to observe trends in pain and interference across different areas of life (such as sleep, physical activity, and mood), and provides them with the option to set physiological and psychological goals as well as a robust library of written and video resources to help manage pain symptoms and to better cope with NF1.

Methods
This paper evaluated the iCanCope-NF to reduce pain severity and interference in adults with NF1. A total of 80 participants across 3 different groups (control, iCanCope-NF access condition, and iCanCope-NF contingency management condition where subjects were provided monetary incentives for engaging with the various features within the app [CM]) completed a randomized clinical trial in which evaluations were completed at intake (initial day of participation), discharge (2 months after intake), and 6 weeks after discharge.

Results
Preliminary data analysis demonstrated individuals randomized to the iCanCope-NF + CM had greater engagement with the mobile app than individuals who were randomized to iCanCope-NF. Additionally, individuals in the iCanCope-NF + CM consistently checked in more (SD 59.5/60 days) than individuals in the iCanCope-NF group (SD 51/60 days). Pain interference, as measured by the Pain Interference Index (PII), was significantly different across all 3 groups at discharge: control (M=6.3), iCanCope (M=5.7), iCanCope + CM (M=5.1), P<.05.

Conclusions
Qualitative interviews completed at discharge for individuals with access to the app indicated that the app was a “wonderful measuring tool” and “provided credibility of my pain symptoms,” and that it was a dramatic and distinctive aide in the monitoring and tracking of their pain symptoms. We demonstrated preliminary acceptability and efficacy for iCanCope-NF as the first pain self-management tool for individuals with NF1. iCanCope-NF + CM was successful in increasing engagement and decreasing pain interference.

Trial Registration
ClinicalTrials.gov NCT04561765; https://clinicaltrials.gov/ct2/show/NCT04561765

Conflicts of Interest
None declared.
A Sociotechnical Model for Managing Mental Health Distress Among College Students During and After a Pandemic: Development and Usability Study
Authors: Tabisula Braden , Uwaoma Chinazunwa 
Published: July 2022

Background
Mental distress affects people's health in many ways and at different levels. However, anxiety and depressive disorder have significantly increased since the outbreak of the COVID-19 pandemic. Controlling the spread of COVID-19 resulted in isolation protocols such as stay-at-home orders, social distancing, and quarantining. Though well intended, the protocols exacerbated the already increasing number of mental distress cases prior to the pandemic. During the rollout of these pandemic interventions to control the spread, there was a noticeable increase in technology use. For instance, to cope with their mental health concerns, several people, including students, turned to technology to sustain their connection to the society and to access mental health services. Although a plethora of technological tools exist for communication and socialization, it is unknown which types of technologies are effective in the management of anxiety and depression symptoms. Hence, there is a need for a sociotechnical model that can identify technologies effective in addressing an individual's mental health symptoms, specifically among college students.

Objective
The objective of this study is to identify the effectiveness of current technologies used in coping with a mental distress situation and to develop a model that college students can use to effectively handle their mental health distress during and after a pandemic.

Methods
The proposed model is built on the Stallman's Health Theory of Coping. The model expands the theory with 5 significant components, namely Mental Health Distress Situation, Level of Distress, Coping Strategy, Technology Used, and the Mental Health Distress Outcome. This paper describes the conceptualized functionality of each component. The model will be implemented as a prototype mobile app and evaluated using a case study with students from 2 colleges.

Results
The study is underway. However, the model will be evaluated using 2 categories of nonrandomized focus groups of college students to determine the usefulness and the effectiveness of the model. Each group will consist of 8 participants. Data collected from each group will be qualitatively evaluated to identify themes from the responses, which will be used to refine the model to meet the study objective.

Conclusions
Many people experienced an increase in mental distress due to the isolation requirements arising from the COVID-19 pandemic. With limited access to traditional coping strategies in public and large gatherings, people turned to technology to manage their stress, anxiety, and depression. However, there is no “one-size-fits-all” technology that can address every individual distress level and coping strategy. Thus, developing a model to identify effective technologies used as coping strategies will be helpful for an individual in alleviating their mental health distress symptoms during and after a pandemic.

Conflicts of Interest
None declared.
Adaptation of a Theory-Based, Clinic-Affiliated Smartphone App to Improve HIV Testing and Pre-exposure Prophylaxis Uptake Among Gay, Bisexual, and Other Men Who Have Sex With Men in Malaysia
Authors: Rosen Aviana O , Wickersham Jeffrey A , Altice Frederick L , Khati Antoine , Luces Jeffrey Ralph , Ni Zhao , Zhou Xin , Azwa Iskandar , Kamarulzaman Adeeba , Ab Halim Mohd Akbar , Shrestha Roman 
Published: July 2022

Background
In Malaysia, HIV disproportionately affects gay, bisexual, and other men who have sex with men (GBMSM). Homosexuality and substance use are criminalized in Malaysia, making GBMSM bear multilevels of social stigma and discrimination, including in health care. Mobile health (mHealth), particularly smartphone apps, is a promising and cost-effective strategy for reaching stigmatized and hard-to-reach populations like GBMSM and linking them to HIV prevention services (eg, HIV testing and pre-exposure prophylaxis [PrEP]), particularly in the context of COVID-19.

Objective
This study aimed to adapt the HealthMindr app (Emory University), which was developed with GBMSM in the United States, to improve HIV testing and PrEP uptake for GBMSM in Malaysia.

Methods
We conducted online focus group discussions (FGDs) between August and September 2021 with 20 GBMSM and 16 community stakeholders (eg, doctors, nurses, pharmacists, and nongovernmental organization staff). Participants were asked questions regarding their preferences for functions and features in mHealth apps among GBMSM and suggestions for adapting the HealthMindr app to the Malaysian context. Each session was digitally recorded and transcribed. Transcripts were inductively coded using Dedoose software (University of California, Los Angeles) and analyzed to identify and interpret emerging themes.

Results
The FGDs with GBMSM revealed preferences for interfacing with apps to access HIV testing, PrEP, and counseling services. Stakeholders showed strong interest in using the app-based platform to deliver integrated care (eg, HIV and mental health). The key themes mostly focused on adaptation and refinement for the Malaysian context and were related to cultural and stylistic preferences (design and user interface), engagement strategies (reward systems, marketing campaigns, and reminders), and recommendations for new functions (enhanced communication options via chat and discussion forums) in a one-stop hub for all HIV prevention needs (HIV self-testing, PrEP, and postexposure prophylaxis) that minimize privacy and confidentiality risks.

Conclusions
Our data suggest that a tailored HIV-prevention app would be acceptable for GBMSM in Malaysia. The findings provided detailed recommendations for the successful adaptation and refinement of the existing platform for optimal use in the Malaysian context.

Conflicts of Interest
None declared.
Prevalence of silent coronary artery disease among patients with type 2 diabetes mellitus in Suleimani, Iraq
Authors: Rashid Taha Hawkar , Hama Karim Omed 
Published: July 2022

Objective: To study the prevalence of silent coronary artery disease among patients with Type 2 Diabetes Mellitus and associated variables.
Methods: A cross sectional multi-center design study in the Sulaymaniyah city. The data collected from patients admitted to medical wards of Shar teaching Hospital, Shahid Hemn teaching Hospital and Faruq medical city. It was conducted during the period of 10 months starting from April, 2017 to Jan, 2018. All patients with type 2 Diabetes Mellitus without symptoms of coronary heart disease were included. Symptoms were evaluated by history, physical examination including blood pressure measurement and searching for other risk factors. The patients were investigated for HbA1c, Lipid profile, resting Electrocardiography (ECG), Echocardiography, Exercise Treadmill test, and CT coronary angiography.
Results: A total of 106 patients, 55 male (51.9%) and 51 female (48.1%) were enrolled in this study, the mean age of the patients was (58.50yr ± 10.94), Nine(8.4%) patients had ischemic change by resting ECG, 10 (9.4%) had ischemic change by Echocardiography, Exercise treadmill test (ETT) was done for 20 patients and revealed positivity for ischemia in only 3(15%) patients, CT coronary angiography was done for three patients and were conclusive for CAD.
Conclusion: Silent coronary artery disease is common in patients with type 2 diabetes mellitus, therefore patients with DM should be carefully evaluated to detect early cardiovascular adverse effect to avoid fatal consequences.