bluuebunny/crossref_metadata_2025_split huggingface dataset:
Costs of acute hospitalisation for stroke and transient ischaemic attack in Australia
Authors: Kim Joosup , Grimley Rohan , Kilkenny Monique F , Cadigan Greg , Johnston Trisha , Andrew Nadine E , Thrift Amanda G , Lannin Natasha A , Sundararajan Vijaya , Cadilhac Dominique A 
Published: June 2022

Background Stroke is a high-cost condition. Detailed patient-level assessments of the costs of care received and outcomes achieved provide useful information for organisation and optimisation of the health system. Objectives To describe the costs of hospital care for stroke and transient ischaemic attack (TIA) and investigate factors associated with costs. Methods Retrospective cohort study using data from the Australian Stroke Clinical Registry (AuSCR) collected between 2009 and 2013 linked to hospital administrative data and clinical costing data in Queensland. Clinical costing data include standardised assignment of costs from hospitals that contribute to the National Hospital Costing programme. Patient-level costs for each hospital admission were described according to the demographic, clinical and treatment characteristics of patients. Multivariable median regression with clustering by hospital was used to determine factors associated with greater costs. Results Among 22 hospitals, clinical costing data were available for 3909 of 5522 patient admissions in the AuSCR (71%). Compared to those without clinical costing data, patients with clinical costing data were more often aged <65 years (30% with cost data vs 24% without cost data, p < 0.001) and male (56% with cost data vs 49% without cost data, p < 0.001). Median cost of an acute episode was $7945 (interquartile range $4176 to $14970) and the median length of stay was 5 days (interquartile range 2 to 10 days). The most expensive cost buckets were related to medical ( n = 3897, median cost $1577), nursing ( n = 3908, median cost $2478) and critical care ( n = 434, median cost $3064). Factors associated with greater total costs were a diagnosis of intracerebral haemorrhage, greater socioeconomic position, in-hospital stroke and prior history of stroke. Conclusion Medical and nursing costs were incurred by most patients admitted with stroke or TIA, and were relatively more expensive on average than other cost buckets such as imaging and allied health. Implications Scaling this data linkage to national data collections may provide valuable insights into activity-based funding at public hospitals. Regular report of these costs should be encouraged to optimise economic evaluations.
Development of graphitic carbon nitride supported novel nanocomposites for green and efficient oxidative desulfurization of fuel oil
Authors: Jabar Ghulam , Saeed Muhammad , Khoso Sadaf , Zafar Anham , Saggu Javed Iqbal , Waseem Amir 
Published: June 2022

The catalysts utilized for oxidative desulfurization have acquired significant attention and ability to improve the quality of the fuel oil by removing sulfur. In this work, the catalysts used for oxidative desulfurization include CoWO4 and Bi2WO6 with graphitic carbon nitride (g-C3N4) as support were synthesized by the one-pot hydrothermal method. Graphitic carbon nitride was obtained by thermal polycondensation of melamine at 550°C for 5 h. These catalysts were homogeneously dispersed on the surface of the support and their structure, morphology, and properties were determined by different characterization techniques (Powder X-Ray Diffractometer, Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy and Energy Dispersive X-Ray Spectroscopy, Specific Surface Area (Brunauer, Emmett and Teller (SBET)). The parameters that affect the efficiency of the desulfurization process such as catalyst amount, amount of oxidizing agent, and reaction temperature have been optimized thoroughly. The oxidative desulfurization reaction was studied in terms of kinetics which shows that reaction is pseudo first order. The thermodynamic studies revealed that the reaction is endothermic and spontaneous in nature. The results determined that the catalytic efficiency for the removal of sulfur (as dibenzothiophene) is more than 90% in the presence of support (g-C3N4) to obtain sulfur free fuel.
Conventions for unconventional language: Revisiting a framework for spoken language features in autism
Authors: Luyster Rhiannon J , Zane Emily , Wisman Weil Lisa 
Published: June 2022

Background and aims Autism has long been characterized by a range of spoken language features, including, for instance: the tendency to repeat words and phrases, the use of invented words, and “pedantic” language. These observations have been the source of considerable disagreement in both the theoretical and applied realms. Despite persistent professional interest in these language features, there has been little consensus around terminology, definitions and developmental/clinical interpretation. Main contribution This review paper updates and expands an existing framework for unconventional language in autism to include a broader range of non-generative (echolalia and self-repetition) and generative (idiosyncratic phrases, neologisms and pedantic language) features often observed in the language of individuals on the autism spectrum. For each aspect of the framework, we review the various definitions and measurement approaches, and we provide a summary of individual and contextual correlates. We also propose some transitional language features that may bridge non-generative and generative domains (e.g., mitigated echolalia and gestalt language). Conclusions This updated framework offers a unified taxonomy and nomenclature that can facilitate further investigation and interpretation of unconventional language in autism. Implications There are important implications of this work for our understanding of the complex interplay between autism and language development. Equally important are the clinical ramifications that will guide evidence-based practice in assessment and intervention for individuals on the autism spectrum.
Effects of magnesium borate on the mechanical performance, thermal and chemical degradation of polyethylene terephthalate packaging material
Authors: Demirel Bilal , Kılıç Esra , Yaraş Ali , Akkurt Fatih , Daver Fugen , Gezer Derya U 
Published: June 2022

This study is on polyethylene terephthalate (PET) compounded with magnesium borate (MB) (Mg2B2O5) powders between (0.2–3.2% by weight) which were synthesized via sol-gel technique at laboratory-scale. The MB/PET composites were characterized in terms of chemical, thermal degradation, and mechanical properties. Their phases and chemical structures were identified by X-ray Diffraction and Fourier Transform Infrared analyses. The MB added into PET matrix significantly reduced PET degrading to acetaldehyde, carboxylic acids and diethylene glycol. However, while at 0.2 wt.% MB isophthalic acid (IPA) decreased and at higher MB concentrations there were higher IPA levels. The added MB increased the composites intrinsic viscosity (IV) compared to the pure PET. The highest IV (0.701 dL/g) was at the 0.2 wt.% MB/PET composite. Both Tg and Tm temperatures trended down up to 3.2 wt.% MB. Compared to pure PET, glass transition temperature (Tg) decreased to 80.4°C (at 3.2 wt.% MB) from 81°C, whereas melt temperature (Tm) decreased to 248.5°C (at 3.2 wt.% MB) from 249.4°C. The MB/PET composite tensile strength increased by 11.31% to a 60 MPa maximum at 0.2 wt.% MB compared to neat PET (53.9 MPa). However, at 0.4 wt. % and higher MB the dispersion was insufficient causing the MB powders to aggregate in the PET matrix, resulting in reduced tensile strength.
Probiotic potential of Tetragenococcus halophilus EFEL7002 isolated from Korean soy Meju
Authors: Kim Da Hye , Kim Seul-Ah , Jo Yu Mi , Seo Hee , Kim Ga Yun , Cheon Seong Won , Yang Su Hwi , Jeon Che Ok , Han Nam Soo 
Published: June 2022

Abstract
Background
Probiotic starters can improve the flavor profile, texture, and health-promoting properties of fermented foods. Tetragenococcus halophilus is a halophilic lactic acid bacterium that is a candidate starter for high-salt fermented foods. However, the species is known to produce biogenic amines, which are associated with neurotoxicity. Here, we report a probiotic starter strain of T. halophilus, EFEL7002, that is suitable for use in high-salt fermentation.

Results
EFEL7002 was isolated from Korean meju (fermented soybean) and identified as T. halophilus, with 99.85% similarity. The strain is safe for use in food as it is a non-hemolytic and non-biogenic amine producer. EFEL7002 is tolerant to gastrointestinal conditions and can adhere to Caco-2 cells. This strain showed antioxidant, anti-inflammatory, and protective effects against the human gut epithelial barrier. EFEL7002 grew well in media containing 0–18% NaCl showing maximum cell densities in 6% or 12% NaCl.

Conclusions
T. halophilus EFEL7002 can be used as a health-promoting probiotic starter culture for various salty fermented foods.
A self-assessment tool for predicting discomfort and tolerance in Chinese patients undergoing esophagogastroduodenoscopy
Authors: Ou Jinqing , Lu Kuiqing , Li Junzhen , Deng Xi , He Junhui , Luo Guijin , Mo Hongdan , Lu Lingli , Yang Man , Yuan Jinqiu , Lei Pingguang 
Published: June 2022

Abstract
Background
For patients taking esophagogastroduodenoscopy (EGD), sedation should ideally be used individually based on patients’ comfort and tolerance level. However, currently there is no valid predictive tool. We undertook this study to develop and temporally validate a self-assessment tool for predicting discomfort and tolerance in Chinese patients undergoing EGD.

Methods
We recruited 1522 patients undergoing routine diagnostic EGD without sedation. We collected candidate predictor variables before endoscopy and evaluated discomfort and tolerance with a 5-point visual analogue scale after the procedure. We developed logistic regression predictive models based on the first 2/3 of participants, and evaluated the calibration and discrimination of the models in the later 1/3 of patients.

Results
30.2% and 23.0% participants reported severe discomfort or poor tolerance to EGD respectively. The predictive factors in the model for discomfort included sex, education, expected level of discomfort, and anxiety before endoscopy. The model for tolerance included income, expected level of discomfort, and anxiety before endoscopy. In the validation population, the established models showed a moderate discriminative ability with a c-index of 0.74 for discomfort and 0.78 for tolerance. Hosmer–Lemeshow test suggested the models had fine calibration ability (discomfort: P = 0.37, tolerance: P = 0.41).

Conclusions
Equations for predicting discomfort and tolerance in Chinese patients undergoing EGD demonstrated moderate discrimination and variable calibration. Further studies are still required to validate these tools in other population.

Trial registration

Chinese Clinical Trial Registry (ChiCTR1800020236).
The genomic and transcriptome characteristics of lung adenocarcinoma patients with previous breast cancer
Authors: Wang Yan , Song Wenpeng , Zhou Sicheng , Chang Shuai , Chang Junke , Tian Jie , Zhang Liming , Li Jue , Che Guowei 
Published: June 2022

AbstractBackgroundBreast cancer and lung cancer are the top two malignancies in the female population and the number of patients with breast cancer and subsequent primary lung cancer has increased significantly in recent years. However, the unique molecular characteristics of this group of patients remains unclear.PurposeTo identify the genomic and transcriptome characteristics of primary lung adenocarcinoma patients with previous breast cancer by comparison with single primary lung adenocarcinoma (SPLA) patients.MethodsThe tumor and normal pulmonary tissue specimens of ten primary pulmonary adenocarcinoma patients with previous breast cancer (multiple primary cancer, MPC) and ten SPLA patients were prospectively collected. The whole exome sequencing (WES) and RNA sequencing (RNA-seq) were performed to analyze the gene mutation and expression differences between MPC and SPC patients.ResultsThe results of WES indicated that the mutations of TRIM73, DLX6 and CNGB1 only existed in MPC patients. The results of RNA-seq manifested the occurrence of second primary lung adenocarcinoma in breast cancer patients was closely associated with cytokine-cytokine receptor action, autophagy, PI3L-Akt, cAMP and calcium ion signaling pathways. Besides, the expression levels of FGF10 and VEGFA genes were significantly increased in MPC patients.ConclusionThe occurrence of second primary lung adenocarcinoma may be related to the cytokine-cytokine receptor action, autophagy, PI3L-Akt, cAMP and calcium ion signaling pathways. Furthermore, the mutations of TRIM73, DLX6 and CNGB1 and high expression of FGF10 and VEGFA might play an important role in the development of lung adenocarcinoma in breast cancer patients. However, more in-depth investigations are needed to verify above findings.
Case series on the Charcot neuroarthropathy in hands after cervical central cord syndrome
Authors: Wang Wenting , Tong Anni , Liu Nan , Biering-Soerensen Fin , Tong Shuai 
Published: June 2022

Abstract
Background
Charcot neuroarthropathy (CNA) of the upper extremity occurs most frequently in shoulders. However, CNA in the hands is uncommon and seldom be reported. The onset of CNA is usually insidious. If this process continues undetected, it can result in joint deformity, ulceration and/or superinfection, loss of function, and amputation or even death. In this article, we are going to present three cases of CNA in the hands of individuals with cervical spinal cord injury (SCI) with central cord syndrome.

Case presentation
Three male individuals with cervical spinal stenosis contracted tetraplegia (American Spinal Injury Association Impairment Scale Grade D, D, and B) due to spinal cord contusion after a trauma and developed hand swelling without pain 2 to 3 months after their SCI. X-ray showed degenerative joint changes in the hands. CNA was considered due to the patient’s history of cervical SCI, loss of motor function and sensation, symptoms of painless swelling, physical examination, and X-ray findings. The self-care sub scores of Spinal Cord Independence Measure III improved slightly only during rehabilitation and follow-up due to poor hand function.

Conclusions
CNA may develop after a central or peripheral neurological disorder. Nearly every joint of the body can be affected and the lower limbs are the most frequently involved. However, CNA of the hand is rare. We present three patients with CNA in the hands after cervical SCI and review the features and early differential diagnosis of CNA. Currently there is no specific treatment available. Therefore, early identification of CNA and adequate protection to the affected joints seem important.
Basic life support knowledge in a war-torn country: a survey of nurses in Yemen
Authors: Alkubati Sameer A. , McClean Christopher , Yu Rebecca , Albagawi Bander , Alsaqri Salman H. , Alsabri Mohammed 
Published: June 2022

Abstract
Background
Successful implementation of Basic life support (BLS) is critical to improving survival rates and outcomes, especially among healthcare workers. To our knowledge, there is no available literature pertaining to the level of BLS knowledge of health care professionals in Yemen.

Methods
Data was collected for this cross-sectional descriptive study from June to August 2020, using a 10-item questionnaire related to cardiopulmonary resuscitation (CPR) and BLS, along with questions on socio-demographic characteristics. Participants were nurses in public and private hospitals located in Al-Rahida and Al-dimna cities, Taiz governance and Hodeidah city, Hodeidah governance in Yemen.

Results
Out of 220 distributed questionnaires, 200 were returned with a response rate of 90.9%. More than a half (53.65%) of answer choices for BLS knowledge were correct. There was a significant difference in knowledge score based on level of education where those who had Bachelor degree had more knowledge (P = 0.000). Those who said they had received training in CPR or received information about CPR had significantly higher scores than those who did not receive (P = 0.000).

Conclusions
BLS knowledge among nurses in Yemen is below an acceptable level to ensure maximum survival in the event of cardiac arrest. Disseminating BLS information and training in a cost effective and efficient manner will provide a large benefit in terms of lives saved with minimal costs.
Cost-consciousness among Chinese medical staff: a cross-sectional survey
Authors: Liang Fei , Hu Shu , Guo Youqi 
Published: June 2022

Abstract
Background
Rapidly increasing health care costs are a widespread problem in the world. The cost-consciousness among Chinese medical staff is an important topic that needs further investigation. Our study aimed to focus on the cost-consciousness of Chinese medical staff and explore the factors related to their cost-consciousness. Differences regarding cost-consciousness between doctors and nurses were also reported.

Methods
Eight hospitals in Liaoning Province, China, were surveyed using a self-reporting questionnaire. A total of 1043 respondents, including 635 doctors and 408 nurses, participated in the study. A revised Chinese Cost-consciousness Scale was used to estimate cost-consciousness.

Results
The mean score of the Cost-consciousness Scale was 27.60 and 28.18 among doctors and nurses, respectively, and there were no significant differences in any personal characteristics. Most Chinese medical staff were aware of the treatment costs and considered cost control as their responsibility. Chinese doctors disliked adhering to guidelines more and preferred to remain independent in making or denying a treatment decision; thus, they like autonomously balancing the treatment and cost. Chinese nurses have similar attitudes, but nurses tended to deny costly services and interventions and were more sensitive to the health care costs by rationing decisions and uncertainty in their medical practice.

Conclusion
We reveal the attitudes regarding cost-consciousness among Chinese medical staff. Chinese medical staff was aware of their responsibility in health cost control. Chinese doctors and nurses had different tendencies with regard to health care cost containment. Our study highlights the importance of education and professional training on cost-consciousness.
“My motivation was to save”: a qualitative study exploring factors influencing motivation of community healthcare workers in a cervical cancer screening program in Dschang, Cameroon
Authors: Hämmerli Pauline , Moukam Alida Datchoua , Wisniak Ania , Sormani Jessica , Vassilakos Pierre , Kenfack Bruno , Petignat Patrick , Schmidt Nicole Christine 
Published: June 2022

AbstractBackgroundCervical cancer is a major public health issue among women in Cameroon and uptake of screening programs remains a challenge in many low- and middle-income countries. Community healthcare workers can play an important role in promoting cervical cancer services. This study aimed to explore factors affecting the motivation of community healthcare workers in a cervical cancer screening program in Dschang, Cameroon.MethodsA qualitative approach including 11 in-depth individual interviews with community healthcare workers was used. The interviews were audio-recorded, transcribed and coded using thematic analysis assisted by ATLAS.ti software.ResultsFour women and seven men aged between 21 and 77 years old were interviewed. Community healthcare workers had high motivation. Factors affecting motivation were divided into individual and environmental level, based on a theoretical framework. Factors with a positive influence on motivation were mainly on the individual side while impeding factors were mainly associated with the environmental level.ConclusionsKey interventions to improve motivation among community healthcare workers include: (i) more training and supportive supervision; (ii) evaluation of remuneration systems by workload; and (iii) provision of job-enabling resources such as uniforms, cellphone cards and transport.Trial registration:Geneva Cantonal Ethics Committee on Human Research (No. 2017-01110) and the Cameroonian National Ethics Committee for Human Health Research (No. 2018/07/1083/CE/CNERSH/SP).
Personal beliefs and social norms regarding the sexual exploitation of girls in age-disparate transactional sexual relationships in Brazil: a mixed-methods study
Authors: Ignacio Caroline Ferraz , Cerdeira Linda , Cislaghi Beniamino , Lauro Giovanna , Buller Ana Maria 
Published: June 2022

Abstract
Background
In the global debate around transactional sex little attention has concentrated on Brazil, despite ranking fourth globally in absolute number of girls married or co-habiting by the age of 15 years, and evidence showing that these unions often begin as age-disparate transactional sex (ADTS). This article contributes to filling this gap by exploring the personal beliefs and social norms related to ADTS in urban (favela) communities of Rio de Janeiro, Brazil between adult men (> 18 years) and girls and adolescents (G/A) (< 18 years) with a minimum 5-year age disparity. The primary objective of this study was to identify the social norms that promote and prevent ADTS, and the dynamics between individual beliefs and social norms, to provide contextualized recommendations to prevent ADTS in this setting.

Methods
An exploratory, sequential, mixed-methods design was used, starting with a qualitative phase that included semi-structured, in-depth interviews and focus groups, and a subsequent quantitative phase comprising of a community survey. The items for the quantitative questionnaires were developed based on the qualitative results.

Results
Mixed methods results indicate that in these communities ADTS is normalised and not considered exploitative. We identified three themes related to the reasons ADTS occurs: girls’ responsibility, male desires and benefits of ADTS. Men’s role in ADTS was largely minimised because of a general acceptance of a notion of masculinity characterised by hypersexuality and lack of impulse control. Individual beliefs, however, did not tend to align with these social norms.

Conclusions
In this study, personal beliefs and social norms often did not align, suggesting that initiatives working to change personal or attitudes regarding ADTS may not lead to meaningful change in ADTS behaviours, and social norms interventions may be more effective. Our findings reinforce the need to develop programs tailored to local understandings of ADTS, targeting not only girls but also a wide range of actors. Interventions could also consider the structural factors acting in local and global contexts that promote or prevent ADTS.