bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving working relationships with families in German early childhood intervention home visitors: A quasi-experimental training study
Authors: Georg Anna K. , Hauschild M. Sc. Sophie , Schröder-Pfeifer Paul , Kasper Lea A. , Taubner Svenja 
Published: August 2022

AbstractBackground Home visitation services within the early childhood intervention program (ECI) for families with a child aged 0–3 in Germany are mainly provided by frontline pediatric nurses and family midwifes. Home visitors are often challenged by difficult interactions with families. Mentalizing, the ability to understand mental states of oneself and others, is a key skill for building effective working relationships, which in turn positively affect intervention outcomes. The aim of this study was to investigate if a mentalizing skills training offered to home visitors active in German ECI contributes to continued professional development. We investigated, whether the training positively affected the quality of the working relationships with families as well as home visitors’ empathy, self-efficacy, and mentalizing. Methods To test the effects of a single day mentalizing skills training on the working relationship inN = 73 ECI home visitors, we used a quasi-experimental design with repeated measures (T0, T1, T2, T3) across seven weeks in order to assess immediate change from baseline (T0) after the training (T2) and stability of changes at follow up (T3). A literature-based intervention was implemented before the training to estimate possible repeated measurement and expectational effects (T1). Primary outcome was the quality of the working relationship experienced by the home visitors. Secondary outcome criteria were empathy, work-related self-efficacy, self-reported and observer-rated mentalizing. Results Significant positive change in the working relationship quality was observed at T2 and at T3. Results on the secondary outcomes were less consistent, with data indicating improvement in empathy and increase on some but not all components of mentalizing. Conclusions This study provides preliminary evidence that brief mentalizing skills trainings may be an effective method for continuous professional qualification in frontline ECI home visitors who afterwards, experience better working relationships with families. Thus, training participation may positively impact efficacy and implementation of home visitations in ECI.
Are the healthcare resources, organisational support and practice in asthma management optimal in the Malaysian primary care setting?
Authors: Hussein Norita , Ramli Rizawati , Liew Su May , Hanafi Nik Sherina , Lee Ping , Cheong Ai Theng , Ghazali Sazlina , Ahad Azainorsuzila Mohd , Patel Jaiyogesh , Schwarze Jurgen , Pinnock Hilary , Khoo Ee Ming 
Published: August 2022

Abstract
Asthma, a common chronic respiratory illness is mostly managed in primary care. We aimed to determine healthcare resources, organisational support, and doctors’ practice in managing asthma in public primary health clinics in Malaysia. A total of six clinics participated. Here, we found only four had dedicated asthma clinics. There was only one clinic which had a tracing defaulter system. Long-term controller medications were available in all clinics, however not adequately provided. Resources, educational materials, and equipment for asthma management were present, though restricted in number and not placed in important areas of the clinic. To diagnose asthma, most doctors used clinical judgement, peak flow meter measurements with reversibility test. Although spirometry is the recommended method to diagnose asthma, it was less practiced, being inaccessibility and unskilled in using as the main reasons. Most doctors reported providing asthma self-management; asthma action plan, but for only half of the patients that they encountered. In conclusion, there is still room for improvement in the provision of clinic resources and support for asthma care. Utilising peak flow meter measurement and reversibility test suggest practical alternative in low resource for spirometry. Reinforcing education on asthma action plan is vital to ensure optimal asthma care.
Effects of the Omicron variant on perinatal outcomes in full-term neonates
Authors: Choi Hyowon , Lee Eun Jung , Ahn Yeon-Soon , Yoo Yeong Myong 
Published: August 2022

Abstract
Background: Research of coronavirus disease (COVID-190 effects on newborns is ongoing. But the research of specific variant’s effects is none. This study analyzed the effects of the Omicron variant on the perinatal outcome of full-term newborns during the pandemic.Methods: Between December 2021 and April 2022, this study was conducted on all newborns who visited a single center. We investigated due to the Omicron maternal infection maternal pregnancy complications, delivery methods, birth week, Apgar scores, neonatal resuscitation program requirement, whether respiratory support was required until 12 h after childbirth, suspicious infectious status, and mortality depending on maternal Omicron infection.Results: A total of 127 neonates were enrolled, and 12 were excluded based on exclusion criteria. Sixteen neonates were born to mothers with a history of Omicron COVID-19, and 99 were born to non-infectious mothers. All infected mothers became infected in the 3rd trimester. Of the 16 mothers, seven had symptomatic, and four met the isolation criteria, according to Korean guidelines. The birth weight of newborns to mothers with COVID history and those without was 2.958 ± 0.272 kg and 3.064 ± 0.461 kg (p=0.049), respectively. The 5-min Apgar score at childbirth was 9.29 ± 0.756 and 9.78 ± 0.460, for neonates born to symptomatic and asymptomatic mothers (p=0.019), respectively. When compared with or without maternal self-isolation, patients requiring needing respiratory support 12 h after birth demonstrated a significant difference (p=0.014; OR, 10.275). Additionally, the presence or absence of transient tachypnea of the newborn showed a significant value (p=0.010; OR 11.929).Conclusions: Owing to Omicron COVID-19, newborns were born with low birth weight, low 5-min Apgar scores, and required respiratory support until 12 h after birth.
Did the increase in sitting time due to COVID-19 lead to over-weight or obesity in adolescents? A study based on the Korea Youth Risk Behavior Web-based Survey (KYRBWS) 2018-2021
Authors: Kim Dahyun , Kim Woorim , Choi Mingee , Shin Jaeyong 
Published: August 2022

Abstract
Introduction: This study aimed to estimate the association between obesity and sitting hours in Korean adolescents with obesity during the coronavirus disease 2019 (COVID-19) pandemic. Since adolescent with obesity is closely linked with the incidence of cardiovascular disease, it is important to identify the factors that increase the prevalence of adolescent with obesity and prevent it early. Methods: We used the Korean Youth Risk Behavior Web-based Survey (KYRBWS) data. The primary outcome variables were changes in obesity status during and after the COVID-19 pandemic. Multiple logistic regression analysis was performed to examine the association between increased sitting hours for purposes other than study and obesity status. Results: The prevalence of obesity was significantly higher during the COVID-19 pan-demic than before the COVID-19 pandemic (odds ratio [OR], 1.186, 95% confidence interval [CI]:1.148–1.226). There was a significant increase in the OR for sitting hours per week for purposes other than study (OR, 1.02, 95% CI, 1.018–1.023). Compared to low household income students, the OR decreased for middle- (OR = 0.801, 95% CI:0.796, 0.871) and high-income household students (OR, 0.832, 95% CI: 0.796–0.871). Discussion/Conclusion: The results of this study confirmed the relationship between sit-ting hours and obesity in adolescents during the pandemic. To prevent or avoid adolescent with obesity, further studies are needed to understand whether the increase in obesity rates during the pandemic is a temporary trend.
Factors Associated with Successful Vaginal Birth after Lower Uterine Transverse Cesarean Section Delivery in Public Hospitals of Bahir Dar city, Northwest, Ethiopia
Authors: Derebe Tigist , Mulat Amlaku , Mihiret Mezgebu , Feyisa Wondu , Tebabal Amanuel , Wubet Tigist , Abeje Bezawit , Lami Magarsa , Worku Tewodros , Azene Zigijit , Nigatu Selamawit , Beyene Aberash 
Published: August 2022

Abstract
Introduction:
Vaginal birth after cesarean section is the term applied to a woman who undergoes vaginal delivery following cesarean section. It is the preferred method to decrease complications associated with repeated cesarean section delivery.
Objectives
This study aimed to assess factors associated with successful vaginal birth after lower uterine transverse cesarean section delivery and to validate the Flamm and Geiger score in the public hospitals of Bahir Dar city, Northwest, Ethiopia.
Methods
Health facility-based retrospective cross-sectional study was conducted from March 1–15/2021 among 345 mothers who gave birth by caesarian section from January 1/2020 to December 31/2020. The data was collected by a simple random sampling technique, entered into Epi data 3.1, and analyzed using SPSS 25.0 version. Logistic regression analyses were done to estimate the crude and adjusted odds ratio with a confidence interval of 95% and a P-value of less than 0.05 considered statistically significant.
Results
This study identified that 35.07% of the women had a successful vaginal birth after one lower uterine transverse cesarean section delivery and among them. Of the failed trial of labor, fetal distress (38.9%) and failed progress of labor (32.1%) were the main indications for emergency cesarean section. Maternal age ≤ 30 years, prior successful vaginal birth after cesarean section delivery, prior vaginal delivery before cesarean section, non-recurrent indication (fetal distress and malpresentation), ruptured membrane, cervical dilatation ≥ 4cm, cervical effacement ≥ 50%, and low station (≥ 0) at admission were associated with successful vaginal birth after one lower uterine transverse cesarean section delivery. For the Flamm and Geiger scores at a cut point of 5, the sensitivity and specificity were 73.6% and 86.6% respectively.
Conclusion
The successful vaginal birth after one lower uterine transverse cesarean section was low in the study area. When the total Flamm and Geiger score increases, the chance of successful vaginal birth after one lower uterine transverse cesarean section increases. We suggest emphasizing the careful selection of women for a trial of labor.
When two’s a crowd - Structural mapping of PEAK pseudokinase interactions identifies 14 3 3 as a molecular switch for PEAK3/Crk signaling.
Authors: Lucet Isabelle , Roy Michael , Surudoi Minglyanna , Kropp Ashleigh , Hou Jianmei , Dai Weiwen , Hardy Joshua , Liang Lung-Yu , Cotton Thomas , Lechtenberg Bernhard , Dite Toby , Ma Xiuquan , Daly Roger , Patel Onisha 
Published: August 2022

Abstract
PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their expression level is associated with several aggressive cancers. Here, we elucidate new molecular details of key PEAK signaling interactions with the adapter proteins CrkII and Grb2 and the scaffold protein 14-3-3. Our findings rationalize why the dimerization of PEAK proteins has a crucial function in signal transduction and provide biophysical and structural data to unravel binding specificity within the PEAK interactome. We identify a conserved high affinity 14-3-3 motif on PEAK3 and demonstrate its role as a molecular switch to regulate CrkII binding. Together, our studies provide a detailed structural snapshot of PEAK interaction networks and further elucidate how PEAK proteins, especially PEAK3, act as dynamic scaffolds that exploit adapter proteins to control signal transduction in cell growth/motility and cancer.
Modelling the batch and fixed bed adsorption of fluoride from aqueous solutions in using activated carbon from Acacia nilotica biochar
Authors: Bhagawati Prashant Basavaraj , Adeogun Abideen Idowu , Shivayogimath Chandrashekhar Basayya , Kadier Abudukeremu 
Published: August 2022

Abstract
Acacia nilotica biomass was used to prepare activated carbon (ANAC-800) through pyrolysis at 800oC. The ANAC-800 was used as adsorbent for the fluoride sequestration in a batch and continuous column systems. The surface morphology, elemental composition as well as particle size distribution of the adsorbent was investigated with Scanning Electron Microscopy (SEM), Elemental and Particle Size Analyzers. What’s more, the influence of initial fluoride concentrations, column packing height and the flow rate on the column efficiency were examine while the efficiency of batch process as a function of contact time and temperature was also investigated. It was found that the kinetic of the process was best fitted with second order model, while the mechanism was best explained by interparticle diffusion model. In addition, the Langmuir Isotherm model showed that the maximum monolayer adsorption capacity of fluoride removal was 71.93 mg/g. The breakthrough curve and column data were well modelled by Adams-Bohart, Yoon-Nelson and Clark model. The models were judged using Akaike Information Criteria (AIC) values after statistical evaluation. ANAC-800 removed fluoride from aqueous solution comparably higher than other adsorbent in its category in batch and continuous column systems.
Effects of different aqueous DO, redox potential and salinity on cyanobacterial colonies from Lake Taihu, China
Authors: Fang Fei , Gan Lin , Jiang Xue , Yang Liuyan 
Published: August 2022

Abstract
In summer, cyanobacteria accumulate at the water surface and form surface blooms when the water column is stable. Cyanobacterial photosynthesis results in oxygen supersatuation during daytime and a great redox potential difference is created between day and night. Cyanobacteria usually exist in colonies in the field, but the microenvironment within colonies is not as easily detected. An accurate analysis of physicochemical properties within the colonies is important to a better understanding of cyanobacterial growth characters and the formation mechanism of cyanobacterial blooms. To investigate the influence of aqueous DO, redox potential and salinity on the characteristics of cyanobacterial colonies from Lake Taihu, dissolved oxygen (DO) microelectrode was used to study the physiological responses in the colonies at different initial aqueous DO, redox potential and salinity. The results showed that DO of the colonies increased with increasing initial aqueous DO level, the highest intercellular DO was achieved at an initial aqueous DO of 1000 µmol L− 1. The maximal net photosynthesis (Pn) and dark respiratory rate (Rdark) was achieved in the colonies incubated at an initial aqueous DO of 100 µmol L− 1 and 1000 µmol L− 1, respectively. DO levels of the colonies decreased with decreasing aqueous redox potential and they decreased with increasing salinity, the highest DO achieved at an redox potential of 0 mV and the lowest DO achieved at a salinity of 8 mg L − 1. The maximal Pn in the colonies was achieved at an redox potential of 0 mV. Abundant oxygen was produced within the colonies in the light and it escaped from the interior of the colonies and then elevated the aqueous DO level. Elevated aqueous DO level in turn promoted the DO production within the colonies. Eventually, a large number of oxygen bubbles were formed and attached to the colonies surface, which could provide a great extra buoyancy for the colonies. All of the physiological responses of the microenvironment within the colonies favor cyanobacteria to be the dominant bloom-forming species and eventually result in water blooms.
Unconventional Isoquinoline-Based SERMs Elicit Fulvestrant-Like Transcriptional Programs in ER+ Breast Cancer Cells
Authors: Fanning Sean , Hancock Govinda , Young Kristen , Hosfield David , Joiner Carstyn , Sullivan Emily , Yildiz Yoldas , Laine Muriel , Greene Geoffrey 
Published: August 2022

Abstract
Estrogen receptor alpha (ERα) is a ligand-dependent master transcriptional regulator and key driver of breast cancer pathology. Small molecule hormones and competitive antagonists favor unique ERα conformational ensembles that elicit ligand-specific transcriptional programs in breast cancer and other hormone-responsive tissues. By affecting disparate ligand binding domain structural features, unconventional ligand scaffolds can redirect ERα genomic binding patterns to engage novel therapeutic transcriptional programs. To improve our understanding of these ERα structure-transcriptional relationships, we have developed a series of chemically unconventional antagonists based on the antiestrogens RAD1901 and lasofoxifene. High-resolution x-ray co-crystal structures show that these molecules affect both classical and unique structural motifs within the ERα ligand binding pocket. They show moderately reduced antagonistic potencies on ERα genomic activities but are effective anti-proliferative agents in luminal breast cancer cells. Interestingly, they show SERM-like ERα accumulation in breast cancer cells but lack uterotrophic activities in an endometrial cell line. RNA sequencing shows that the lead molecules mediate transcriptional pathways similar to fulvestrant and other SERDs in these cells. This advance shows that fulvestrant-like genomic activities can be achieved without affecting ERα accumulation in breast cancer cells.
Neglected gaps in improving the health, wellbeing, and care for sexual and gender minority young people living in low- and lower-middle- income countries: a scoping review
Authors: Kraus-Perrotta Cara , Garnsey Camille , DeMulder Jessica 
Published: August 2022

Abstract
Background
There is a lack of reliable data on the size, characteristics, and experiences of sexual and gender minority (SGM) young people (ages 10–24) in low- and lower-middle- income countries (LMICs). This review examines the scant research conducted in the last decade with and about SGM young people living in low-income settings and seeks to answer the question: What is known about the mental and physical health needs, safety, and wellbeing of SGM young people living in LMICs?
Methods
We conducted a scoping review informed by the methodological frameworks put forth by Arksey and O’Malley and the Joanna Briggs Institute. We systematically searched two general social science databases and one topic-specific database for peer-reviewed papers, of any research design, that included SGM young people or explored attitudes toward SGM young people in LMICs. We included papers that reported on factors influencing the health and wellbeing of SGM populations, including physical and mental health, healthcare-seeking behaviors, substance use, experiences of discrimination and/or stigma, experiences of violence and abuse (emotional, physical, and/or sexual), economically motivated paid sex practices, housing or economic security, and attitudes of others toward SGM populations.
Results
Of the 3,729 unique records identified, 47 papers drawing from data collected from 44 unique studies met the inclusion criteria. Only 26 of the 47 papers included SGM young people as participants, with just 10 exclusively focusing on young people ages 10–24. The included papers were classified into three thematic groupings: attitudes toward SGM populations (n = 20), risks to the health of SGM populations (n = 19), and experiences of stigma and discrimination among SGM populations (n = 8).
Conclusion
The findings indicate that the research that does exist for SGM young people in LMICs is disjointed and sparse, and often studies are about SGM young people, rather than with and for them. Our review highlights the need for more and better research, more accurate and disaggregated demographic data, and leadership and participation of SGM-led community-based organizations in the co-design of studies that are about them.
Photoaging and theory-based intervention to improve sun protection behaviors in students in Zahedan: study protocol for a randomized controlled trial
Authors: Okati-Aliabad Hassan , Hosseini Esmat Sadat , Sharifabad Mohammad Ali Morowati , Mohammadi Mahdi , Ardakani Mohamad Ebrahimzadeh , Talebrouhi Amir Hossein 
Published: August 2022

AbstractBackground: Excessive exposure to solar ultraviolet (UV) radiation can cause skin cancer. Implementing new technologies and computational algorithms can potentially change the outlook for cancer prevention and facilitate early detection of melanoma, thereby reducing mortality. Mobile technology as a potential provider of health services in delivering health information and conducting interventions, especially in skin fields, where a significant part of diagnosis is based on visual examination, can be important. Evidence showed that constructs of protection motivation theory (PMT) were good predictors of practicing sun protection behaviors in students. This study will investigate whether mobile applications improve safe and healthy behaviors and affect students' reduced UV exposure.Method/design: This randomized controlled trial will be conducted on 320 students in 06/04/2022 in Zahedan. We created mobile applications (Sunshine and Skin Health and WhatsApp apps). Sunshine and Skin Health app allows users to see their changed faces in three stages of adolescence, middle age, and old age based on sun protection behavior. The WhatsApp app has 27 health messages based on PMT theory, eight educational files, and a skin cancer clip that will be sent through WhatsApp during a week. Randomization will be performed using a 1:1 (control: intervention) ratio. The primary endpoint is the group difference in sun-protective behaviors immediately after the intervention. The secondary endpoint is the group difference in sun-protective behaviors at a 3-month follow-up. The data will be analyzed in SPSS.22, and the significance level will be considered 0.05.Discussion: The present study examines the effectiveness of mobile applications in improving sun-protective behaviors. If this intervention enhances sun protection behaviors, it can prevent students' skin damage.Trial registration: This trial was prospectively registered on theIranian Registry of Clinical Trialson February 8, 2021 (IRCT20200924048825N1).