bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in prenatal care and birth outcomes after federally qualified health center expansion
Authors: Gourevitch Rebecca A. , Hatfield Laura A. 
Published: November 2022

AbstractObjectiveTo evaluate whether the expansion of Federally Qualified Health Centers (FQHCs) improved late prenatal care initiation, low birth weight, and preterm birth among Medicaid‐covered or uninsured individuals.Data Sources and Study SettingWe identified all FQHCs in California using the Health Resources and Services Administration's Uniform Data System from 2000 to 2019. We used data from the U.S. Census American Community Survey to describe area characteristics. We measured outcomes in California birth certificate data from 2007 to 2019.Study DesignWe compared areas that received their first FQHC between 2011 and 2016 to areas that received it later or that had never had an FQHC. Specifically, we used a synthetic control with a staggered adoption approach to calculate non‐parametric estimates of the average treatment effects on the treated areas. The key outcome variables were the rate of Medicaid or uninsured births with late prenatal care initiation (>3 months' gestation), with low birth weight (<2500 grams), or with preterm birth (<37 weeks' gestation).Data Collection/Extraction MethodsThe analysis was limited to births covered by Medicaid or that were uninsured, as indicated on the birth certificate.Principal FindingsThe 55 areas in California that received their first FQHC in 2011–2016 were more populous; their residents were more likely to be covered by Medicaid, to be low‐income, or to be Hispanic than residents of the 48 areas that did not have an FQHC by the end of the study period. We found no statistically significant impact of the first FQHC on rates of late prenatal care initiation (ATT: −10.4 [95% CI −38.1, 15.0]), low birth weight (ATT: 0.2 [95% CI −7.1, 5.4]), or preterm birth (ATT: −7.0 [95% CI −15.5, 2.3]).ConclusionsOur results from California suggest that access to primary and prenatal care may not be enough to improve these outcomes. Future work should evaluate the impact of ongoing initiatives to increase access to maternal health care at FQHCs through targeted workforce investments.
Obstructor, a Frankliniella occidentalis protein, promotes transmission of tomato spotted wilt orthotospovirus
Authors: Zheng Xiaobin , Wan Yanran , Tao Min , Yuan Jiangjiang , Zhang Kun , Wang Jing , Zhang Youjun , Liang Pei , Wu Qingjun 
Published: November 2022

AbstractTomato spotted wilt orthotospovirus (TSWV) causes substantial economic losses to vegetables and other crops. TSWV is mainly transmitted by thrips in a persistent and proliferative manner, and its most efficient vector is the western flower thrips, Frankliniella occidentalis (Pergande). In moving from the thrips midgut to the salivary glands in preparation for transmission, the virions must overcome multiple barriers. Although several proteins that interact with TSWV in thrips have been characterized, we hypothesized that additional thrips proteins interact with TSWV and facilitate its transmission. In the current study, 67 F. occidentalis proteins that interact with GN (a structural glycoprotein) were identified using a split‐ubiquitin membrane‐based yeast 2‐hybrid (MbY2H) system. Three proteins, apolipoprotein‐D (ApoD), orai‐2‐like (Orai), and obstructor‐E‐like isoform X2 (Obst), were selected for further study based on their high abundance and interaction strength; their interactions with GN were confirmed by MbY2H, yeast β‐galactosidase and luciferase complementation assays. The relative expressions of ApoD and Orai were significantly down‐regulated but that of Obst was significantly up‐regulated in viruliferous thrips. When interfering with Obst in larval stage, the TSWV acquisition rate in 3 independent experiments was significantly decreased by 26%, 40%, and 35%, respectively. In addition, when Obst was silenced in adults, the virus titer was significantly decreased, and the TSWV transmission rate decreased from 66.7% to 31.9% using the leaf disk method and from 86.67% to 43.33% using the living plant method. However, the TSWV acquisition and transmission rates were not affected by interference with the ApoD or Orai gene. The results indicate that Obst may play an important role in TSWV acquisition and transmission in Frankliniella occidentalis.
Three amino acid substitutions contributing to thermostability of phosphoglucose isomerase in the Glanville fritillary butterfly
Authors: Yang Jianing , Wang Di , Liu Hui , Wang Lin , Jin Ling , Ahola Virpi , Xu Chongren , Wang Rongjiang 
Published: November 2022

AbstractTemperature is one of the most important environmental factors that affect organisms, especially ectotherms, due to its effects on protein stability. Understanding the general rules that govern thermostability changes in proteins to adapt high‐temperature environments is crucial. Here, we report the amino acid substitutions of phosphoglucose isomerase (PGI) related to thermostability in the Glanville fritillary butterfly (Melitaea cinxia, Lepidoptera: Nymphalidae). The PGI encoded by the most common allele inM. cinxiain the Chinese population (G3‐PGI), which is more thermal tolerant, is more stable under heat stress than that in the Finnish population (D1‐PGI). There are 5 amino acid substitutions between G3‐PGI and D1‐PGI. Site‐directed mutagenesis revealed that the combination of amino acid substitutions of H35Q, M49T, and I64V may increase PGI thermostability. These substitutions alter the 3D structure to increase the interaction between 2 monomers of PGI. Through molecular dynamics simulations, it was found that the amino acid at site 421 is more stable in G3‐PGI, confining the motion of the α‐helix 420–441 and stabilizing the interaction between 2 PGI monomers. The strategy for high‐temperature adaptation through these 3 amino acid substitutions is also adopted by other butterfly species (Boloria eunomia,Aglais urticae,Colias erate, andPolycaena lua) concurrent withM. cinxiain the Tianshan Mountains of China, i.e., convergent evolution in butterflies.
A randomized clinical trial of beetroot juice consumption on inflammatory markers and oxidative stress in patients with type 2 diabetes
Authors: Karimzadeh Laleh , Behrouz Vahideh , Sohrab Golbon , Hedayati Mehdi , Emami Golpar 
Published: November 2022

AbstractOxidative stress and chronic inflammation are both major underlying factors for the initiation and progression of diabetes, as well as for the development of long‐term diabetes‐related consequences in patients with type 2 diabetes mellitus (T2DM). This study was designed to evaluate the effects of beetroot juice (BJ) consumption on oxidative stress and inflammatory markers in patients with T2DM. In this trial, 52 patients with T2DM were randomly assigned to either the concentrated BJ or the control group. The BJ group received 12 ml concentrated BJ twice daily, whereas the control group received no intervention. At the baseline and the end of week 12, plasma levels of malondialdehyde (MDA), high sensitive C‐reactive protein (hs‐CRP), interleukin‐6 (IL‐6), tumor necrosis factor‐α (TNF‐α), and nuclear factor‐κB (NF‐κB) were measured. Compared with the control group, BJ reduced IL‐6 (−0.1 vs. 0.83, P = 0.001), TNF‐α (−1.28 vs. 5.51, P = 0.001), and NF‐κB (−0.03 vs. 0.36, P = 0.005) after 12‐week intervention; plasma concentration of MDA and hs‐CRP did not change between groups after intervention. Intra‐group comparison disclosed that daily BJ consumption could not change oxidative stress and inflammatory markers except for TNF‐α (−1.28 ± 2.31, P = 0.026) compared with the baseline. However, the concentrations of IL‐6, TNF‐α, and NF‐κB increased significantly in the control group at the end of week 12 compared to baseline (19.5%, P = 0.001; 120%, P = 0.001; and 69%, P = 0.021, respectively). In conclusion, our study indicates that daily consumption of BJ reduces the concentrations of some inflammatory markers, including IL‐6, TNF‐α, and NF‐κB, which are involved in the pathogenesis of complications of T2DM.Practical ApplicationBeetroot juice concentrate contains nutrients such as antioxidants that can improve the health status of people with type 2 diabetes.
Corporate green innovation and stock liquidity in China
Authors: Chen Zhongfei , Xiao Yu , Jiang Kangqi 
Published: November 2022

AbstractUtilising data from listed companies in China from 2007 to 2020, we first examine whether and how corporate green innovation affects stock liquidity. We demonstrate that corporate green innovation, especially green invention innovation, significantly increases stock liquidity. This promotion effect is stronger in small enterprises, enterprises in cities with serious air pollution, and enterprises in regions with strict environmental regulations. The mechanism analysis suggests that green innovation reduces information asymmetry and improves the financial performance of enterprises. Finally, we explore what types of investors prefer green innovation, and confirm that corporate green innovation is favoured by green investors.
Polyvinyl alcohol, but not bovine serum albumin, promotes the induction of full‐type hyperactivation in boar cyclic AMP analog‐treated spermatozoa
Authors: Sai Seiken , Harayama Hiroshi 
Published: November 2022

AbstractThis study aimed to verify the effects of polyvinyl alcohol (PVA) and bovine serum albumin (BSA) on the induction of full‐type hyperactivation in boar spermatozoa treated with a cyclic AMP analog (cBiMPS). Washed spermatozoa were treated with cBiMPS (100 μM) for 180 min. As shown in the assessment of sperm motility, PVA (0.05%–0.4%) significantly promoted the induction of full‐type hyperactivation, whereas BSA (0.025%–0.4%) did not affect the induction. In comparative experiments, BSA (0.4%) effectively promoted the induction of full‐type hyperactivation in bovine spermatozoa treated with cBiMPS, calyculin A (a protein phosphatase inhibitor), and digoxin (a Na+/K+‐ATPase inhibitor), while PVA (0.1%) did not affect the induction. Western blotting showed that protein tyrosine phosphorylation states of >50 kDa sperm proteins were effectively enhanced by treatment with cBiMPS in the PVA/BSA‐free medium and not affected by the addition of PVA (0.1%). The assessment of plasma membrane integrity indicated that BSA (0.4%) significantly decreased spermatozoa with intact plasma membranes. These results indicate that PVA (0.1%) promotes the induction of full‐type hyperactivation and does not influence the protein tyrosine phosphorylation states in boar cBiMPS‐treated spermatozoa. They also suggest that BSA should not be added to medium containing cBiMPS for boar spermatozoa.
“Everyone Wants to Feel Like a Movie Star”: Aesthetics, Work, Pleasure, and Caste in India
Authors: Malik Lakshita 
Published: November 2022

AbstractThis article explores the social category of work as it intersects with pleasure (mazaa). Through an ethnography of beauty workers in urban New Delhi, in interwoven digital and non‐digital spaces, I interrogate how certain forms of work are valued at the expense of others. Beauty work refers to the broad category of work that enhances the physical appearance of oneself or others. It is a part of the new categories of entrepreneurial work that have emerged in post‐liberalization India, where demands for consumer goods and services have escalated. I focus on makeup artists and beauticians: two categories of relationally produced beauty workers. While the former are popularly constructed as creative workers, the latter are viewed as providing mundane and dull forms of labor pertaining to bodily cleanliness, like body‐hair removal. Pleasure, through creativity, sutures practices of work in relation to categories of class, capital, labor, caste, gender, and aesthetics. Creativity and pleasure, then, emerge as sites of articulating caste‐based immunocapital (Olivarius 2019). I argue that mazaa becomes a negotiated and historically situated site for negotiating caste‐based immaterial (immuno)capital.
Effects of soothing images and soothing sounds on mood and well‐being
Authors: Witten Emily , Ryynanen Jasmiina , Wisdom Stella , Tipp Cheryl , Chan Stella W. Y. 
Published: November 2022

AbstractObjectivesMental health problems are increasing at an alarming rate, calling for the need for more cost‐effective and easily accessible interventions. Visual images and sounds depicting nature have been found to have positive effects on individuals' mood and well‐being; however, the combined effects of images and sounds have been scarcely investigated. This study therefore aimed to compare the mood effects of viewing nature‐related soothing images versus listening to soothing sounds versus a combination of both.MethodsIn this study, 149 participants aged 18–83 years old (M = 35.88, SD = 15.63; 72.5% female, male 26.8%, .7% transgender) were randomised into three intervention conditions: images only, sounds only or combined (images and sounds). Baseline depressive and anxiety symptoms were indexed, and four outcome variables (positive affect, negative affect, serenity affect and depressive mood states) were measured pre‐ and post‐intervention.ResultsFindings showed that all participants, regardless of group, reported a decrease in negative affect, positive affect and depressive mood as well as an increase in serenity affect (including feelings of soothe). However, there were no group differences. Exploratory analyses found that individuals with higher levels of depressive and anxiety symptoms at baseline experienced greater reduction in negative affect and depressive mood state, as well as a larger increase in serenity affect.ConclusionsThese findings therefore provide preliminary evidence that, upon further research and development, images and sounds depicting nature can potentially be developed for use as an effective tool to improve mood and well‐being.
Cause of death and excess mortality in patients with lower‐risk myelodysplastic syndromes (MDS): A report from the European MDS registry
Authors: Mądry Krzysztof , Lis Karol , Fenaux Pierre , Bowen David , Symeonidis Argiris , Mittelman Moshe , Stauder Reinhard , Čermák Jaroslav , Sanz Guillermo , Hellström‐Lindberg Eva , Langemeijer Saskia , Malcovati Luca , Germing Ulrich , Holm Mette Skov , Guerci‐Bresler Agnes , Culligan Dominic , Sanhes Laurence , Kotsianidis Ioannis , van Marrewijk Corine , Crouch Simon , de Witte Theo , Smith Alex ,   the EUMDS Registry Participants
Published: November 2022

SummaryInformation on causes of death (CoDs) and the impact of myelodysplastic syndromes (MDS) on survival in patients with lower‐risk MDS (LR‐MDS) is limited. A better understanding of the relationship between disease characteristics, clinical interventions and CoDs may improve outcomes of patients with LR‐MDS. We prospectively collected data on patients with LR‐MDS in the European MDS registry from 2008 to 2019. Clinical, laboratory and CoDs data were obtained. To examine MDS‐specific survival, relative survival (RS) was estimated using national life tables. Of 2396 evaluated subjects, 900 died (median overall survival [OS]: 4.7 years; median follow‐up: 3.5 years). The most common CoDs were acute myeloid leukaemia/MDS (20.1%), infection (17.8%) and cardiovascular disease (CVD; 9.8%). Patients with isolated del(5q) and with red cell transfusion needed during the disease course, had a higher risk of fatal CVD. The 5‐year OS was 47.3% and the 5‐year RS was 59.6%, indicating that most patients died due to their underlying MDS. Older patients (aged >80 years) and the lowest‐risk patients were more likely to die from competing causes. This study shows that MDS and its related complications play crucial role in the outcome of patients with LR‐MDS.
Proteolytic cleavage of membrane proteins by membrane type‐1 MMP regulates cancer malignant progression
Authors: Ikeda Kazuki , Kaneko Ryo , Tsukamoto Eiki , Funahashi Nobuaki , Koshikawa Naohiko 
Published: November 2022

AbstractStrategies to develop cancer therapies using inhibitors that target matrix metalloproteinases (MMPs), particularly membrane type‐1 MMP (MT1‐MMP), have failed. This is predominantly attributed to the specificity of MMP inhibitors and numerous functions of MMPs; therefore, targeting substrates with such broad specificity can lead to off‐target effects. Thus, new drug development for cancer therapeutics should focus on the ability of MT1‐MMP to break down substrates, such as functional cell membrane proteins, to regulate the functions of these proteins that promote tumor malignancy. In this review, we discuss the mechanism by which proteolysis of cell surface proteins by MT1‐MMP promotes progression of malignant tumor cells. In addition, we discuss the two protein fragments generated by limited cleavage of erythropoietin‐producing hepatoma receptor tyrosine kinase A2 (EphA2‐NF, ‐CF), which represent a promising basis for developing new cancer therapies and diagnostic techniques.
Targeted advertising and costly consumer search
Authors: Burguet Roberto , Petrikaitė Vaiva 
Published: November 2022

AbstractWe study targeting of advertising based on information about the consumer's likely ranking of products. Firms send ads to more promising consumers. Thus, targeting increases the expected willingness to pay for the product the consumer learns about but also reduces the expected differentiation of these products. The two effects push search, and so prices, in opposite direction. The first effect is more important for lower search costs. The second is stronger the larger the number of products. The improved selection under targeting increases firms' profitability and so advertising effort.
Virtual and augmented reality in dental education: The good, the bad and the better
Authors: Dzyuba Nikita , Jandu Jai , Yates Julian , Kushnerev Evgeny 
Published: November 2022

AbstractIntroductionVirtual reality and augmented reality (VR/AR) are becoming established technologies with a wide range of possibilities in various academic fields, including dentistry. The practice of dentistry encompasses a spectrum of skills and knowledge of anatomy, complex technical and clinical skills and sound academic understanding. This review aims to scope the current use of these technologies in dental education, explore their impact on teaching and learning and envisage their potential in this field.Materials and MethodsThe Cochrane Library, PubMed and EMBASE were searched. Cochrane Handbook was used to conduct this systematic review. Inclusion and exclusion criteria were applied; randomised control trials published in English in the last 10 years (2010–2020) were considered and screened independently by two authors.ResultsFourteen of 524 studies were included and assessed. The majority of articles describing the use of VR/AR focused on an Undergraduate/General Dental Practitioner audience. Its use in Oral and Maxillofacial Surgery, Endodontics and Restorative dentistry was also described. There is evidence of motor skill acquisition using these systems which is comparative to that of traditional methods.ConclusionThe use of VR/AR is well established in dental education; most applications relate to undergraduate education as a useful adjunct to dental training. In this article, the breadth of learning in dental education using VR/AR was exploited providing an overview to aid dental education. VR/AR is a useful adjunct to conventional learning in dentistry. However, there are limitations preventing VR/AR widespread use and applications, such as lack of trials, standardisation and accreditation of systems/content.
Ceci n'est pas une école: Discourses of artificial intelligence in education through the lens of semiotic analytics
Authors: Blikstein Paulo , Zheng Yipu , Zhou Karen Zhuqian 
Published: November 2022

AbstractNew ideas and technologies enable new ways of doing as well as new forms of language. The rise of Artificial Intelligence (AI) is no exception. The implications of changing activity and language take on new gravity in certain fields to which AI is applied, such as education (AIEd). Terms like smart, intelligence, and learning, which had certain meanings when describing human cognition, take on new meanings in the context of computational systems, with the potential for polysemy when the human and computational meanings meet. This article unpacks what AIEd companies mean when they use these terms. Drawing on findings from a mixed‐methods study, we first describe how AIEd companies used these terms on two websites. Then, using Natural Language Processing techniques, we quantitatively analyse a corpus of over 65,000 words scraped from 26 AIEd company websites. Our analyses suggest that commonly promoted narratives around student learning and 21st Century skill‐building are not supported by the language on AIEd company websites, which focus instead on mass customization, efficiency, and monitoring—all tasks at which computers excel. Also, notably scarce in the corpus were extensive articulations on ethics. Given these findings we propose that although AIEd companies create powerful new technical possibilities, they must also be evaluated for the powerful ways in which they shape narratives around the use of technology in education and the behaviours and capabilities that constitute education.
Beyond ANOVA and MANOVA for repeated measures: Advantages of generalized estimated equations and generalized linear mixed models and its use in neuroscience research
Authors: de Melo Márcio Braga , Daldegan‐Bueno Dimitri , Menezes Oliveira Maria Gabriela , de Souza Altay Lino 
Published: November 2022

AbstractIn neuroscience research, longitudinal data are often analysed using analysis of variance (ANOVA) and multivariate analysis of variance (MANOVA) for repeated measures (rmANOVA/rmMANOVA). However, these analyses have special requirements: The variances of the differences between all possible pairs of within‐subject conditions (i.e., levels of the independent variable) must be equal. They are also limited to fixed repeated time intervals and are sensitive to missing data. In contrast, other models, such as the generalized estimating equations (GEE) and the generalized linear mixed models (GLMM), suggest another way to think about the data and the studied phenomenon. Instead of forcing the data into the ANOVAs assumptions, it is possible to design a flexible/personalized model according to the nature of the dependent variable. We discuss some advantages of GEE and GLMM as alternatives to rmANOVA and rmMANOVA in neuroscience research, including the possibility of using different distributions for the parameters of the dependent variable, a better approach for different time length points, and better adjustment to missing data. We illustrate these advantages by showing a comparison between rmANOVA and GEE in a real example and providing the data and a tutorial code to reproduce these analyses in R. We conclude that GEE and GLMM may provide more reliable results when compared to rmANOVA and rmMANOVA in neuroscience research, especially in small sample sizes with unbalanced longitudinal designs with or without missing data.