bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nature-based recreation for the elderly in urban areas: assessing opportunities and demand as planning support
Authors: Wen Chen , Albert Christian , von Haaren Christina 
Published: July 2022

Abstract
Background
With elderly people comprising a growing share of the population, landscape planners need to consider their specific requirements to enhance the opportunities for them to engage in nature-based recreation (NBR). However, few studies have spatially assessed the recreation potential, demand, and opportunities for elderly people in cities. Thus, this paper aimed to spatially model and investigate the NBR opportunities for and demand of elderly people in urban areas. A spatial framework based on the ESTIMAP recreation model was developed, considering special factors to better reflect elderly people’s preferences regarding NBR at the city scale. In particular, NBR opportunities were assessed considering landscape aesthetics, various types of facilities, and proximity. The street network was used to understand elderly people’s walking behaviours regarding green spaces and related facilities.

Results
A case study in Hannover, Germany, demonstrated the applicability of the proposed method. The results illustrate the spatial heterogeneity of recreation options for the elderly. Only parts of Hannover’s green spaces offer high recreation opportunities for elderly people. Many of the existing green spaces lack diverse landscape components and sufficient supply of facilities, resulting in a compromise to aesthetics and recreational opportunities.

Conclusions
The proposed method contributes to research on spatial planning and environmental justice by incorporating vulnerable groups’ preferences and needs in spatially assessing NBR. The planning implications highlight pocket gardens and greenways connecting communities and parks as development opportunities in the city.
The prognostic value of 18F-FDG PET/CT intra-tumoural metabolic heterogeneity in pretreatment neuroblastoma patients
Authors: Liu Jun , Si Yukun , Zhou Ziang , Yang Xu , Li Cuicui , Qian Luodan , Feng Li Juan , Zhang Mingyu , Zhang Shu Xin , Liu Jie , Kan Ying , Gong Jianhua , Yang Jigang 
Published: July 2022

AbstractBackgroundNeuroblastoma (NB) is the most common tumour in children younger than 5 years old and notable for highly heterogeneous. Our aim was to quantify the intra-tumoural metabolic heterogeneity of primary tumour lesions by using18F-FDG PET/CT and evaluate the prognostic value of intra-tumoural metabolic heterogeneity in NB patients.MethodsWe retrospectively enrolled 38 pretreatment NB patients in our study.18F-FDG PET/CT images were reviewed and analyzed using 3D slicer software. The semi-quantitative metabolic parameters of primary tumour were measured, including the maximum standard uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG). The areas under the curve of cumulative SUV-volume histogram index (AUC-CSH index) was used to quantify intra-tumoural metabolic heterogeneity. The median follow-up was 21.3 months (range 3.6 - 33.4 months). The outcome endpoint was event-free survival (EFS), including progression-free survival and overall survival. Survival analysis was performed using Cox regression models and Kaplan Meier survival plots.ResultsIn all 38 newly diagnosed NB patients, 2 patients died, and 17 patients experienced a relapse. The AUC-CSHtotal(r=0.630, P<0.001) showed moderate correlation with the AUC-CSH40%. In univariate analysis, chromosome 11q deletion (P=0.033), Children's Oncology Group (COG) risk grouping (P=0.009), bone marrow involvement (BMI, P=0.015), and AUC-CSHtotal(P=0.007) were associated with EFS. The AUC-CSHtotal(P=0.036) and BMI (P=0.045) remained significant in multivariate analysis. The Kaplan Meier survival analyses demonstrated that patients with higher intra-tumoural metabolic heterogeneity and BMI had worse outcomes (log-rank P=0.002).ConclusionThe intra-tumoural metabolic heterogeneity of primary lesions in NB was an independent prognostic factor for EFS. The combined predictive effect of intra-tumoural metabolic heterogeneity and BMI provided prognostic survival information in NB patients.
Design, implementation, and evaluation of self-care program in the prevention of breast cancer among women in Isfahan: a community-based participatory action research protocol
Authors: Kianpour Maryam , Taleghani Fariba , Noroozi Mahnaz , Savabi-Esfahani Mitra , Boroumandfar Zahra , Changiz Tahereh , Ravankhah Zahra , Javanmard Shaghayegh Haghjooy , Hashemi Maryam Sadat 
Published: July 2022

Abstract
Introduction
Breast cancer is one of the most prevalent cancers among women in Isfahan, Iran; however, its prevention is not desirable in this city. This disease poses several health, social and economic challenges for women. To promote women's self-care in breast cancer prevention, this study aims to design, implement and evaluate a self-care program among women in Isfahan through using a community-based participatory action research method.

Methods
The present study is based on a community-based participatory action research approach. In this study, the participatory action research includes four general phases of organizing, action planning, action, and rethinking. These phases are summarized as follows: In the organizing phase, the needs of the participants and the action research settings are examined. This means that the current situation is identified and the views of the process owners are assessed. In the action planning phase, using the results of the first phase, some strategies are designed to promote self-care behaviors in the prevention of breast cancer among women in Isfahan. In the implementation phase, the selected strategies are implemented with the help of the process owners. Finally, in the rethinking phase, the results of the implementation of the strategies are monitored and evaluated. This cycle continues until the intended results are achieved.

Discussion
Changing the role of individuals from a passive status to an aware and active status in the care process requires motivation, responsibility, and active participation of individuals in the disease control process. Moreover, many cultural and social factors affect the active participation of Iranian women. Therefore, individuals can be involved in promoting their health using a community-based participatory action research approach.
Investor sentiments and stock markets during the COVID-19 pandemic
Authors: Cevik Emre , Kirci Altinkeski Buket , Cevik Emrah Ismail , Dibooglu Sel 
Published: July 2022

AbstractThis study examines the relationship between positive and negative investor sentiments and stock market returns and volatility in Group of 20 countries using various methods, including panel regression with fixed effects, panel quantile regressions, a panel vector autoregression (PVAR) model, and country-specific regressions. We proxy for negative and positive investor sentiments using the Google Search Volume Index for terms related to the coronavirus disease (COVID-19) and COVID-19 vaccine, respectively. Using weekly data from March 2020 to May 2021, we document significant relationships between positive and negative investor sentiments and stock market returns and volatility. Specifically, an increase in positive investor sentiment leads to an increase in stock returns while negative investor sentiment decreases stock returns at lower quantiles. The effect of investor sentiment on volatility is consistent across the distribution: negative sentiment increases volatility, whereas positive sentiment reduces volatility. These results are robust as they are corroborated by Granger causality tests and a PVAR model. The findings may have portfolio implications as they indicate that proxies for positive and negative investor sentiments seem to be good predictors of stock returns and volatility during the pandemic.
Advances on the modification and biomedical applications of acellular dermal matrices
Authors: Chen Yining , Liu Xinhua , Zheng Xin , Huang Xuantao , Dan Weihua , Li Zhengjun , Dan Nianhua , Wang Yunbing 
Published: July 2022

AbstractAcellular dermal matrix (ADM) is derived from natural skin by removing the entire epidermis and the cell components of dermis, but retaining the collagen components of dermis. It can be used as a therapeutic alternative to “gold standard” tissue grafts and has been widely used in many surgical fields, since it possesses affluent predominant physicochemical and biological characteristics that have attracted the attention of researchers. Herein, the basic science of biologics with a focus on ADMs is comprehensively described, the modification principles and technologies of ADM are discussed, and the characteristics of ADMs and the evidence behind their use for a variety of reconstructive and prosthetic purposes are reviewed. In addition, the advances in biomedical applications of ADMs and the common indications for use in reconstructing and repairing wounds, maintaining homeostasis in the filling of a tissue defect, guiding tissue regeneration, and delivering cells via grafts in surgical applications are thoroughly analyzed. This review expectedly promotes and inspires the emergence of natural raw collagen-based materials as an advanced substitute biomaterial to autologous tissue transplantation.

Graphical Abstract
A new strategy: identification of specific antibodies for neutralizing epitope on SARS-CoV-2 S protein by LC-MS/MS combined with immune repertoire
Authors: Yu Meng , Zhu Zhu , Wang Yanqun , Wang Pingzhang , Jia Xiaodong , Wang Jie , Liu Lei , Liu Wanbing , Zheng Yaqiong , Kou Guomei , Xu Weiyan , Huang Jing , Lu Fengmin , Zou Xiajuan , Zheng Shangen , Lu Yinying , Zhao Jincun , Dai Hui , Qiu Xiaoyan 
Published: July 2022

AbstractAlthough the SARS-CoV-2 vaccine has been widely used worldwide, not all individuals can produce neutralization antibodies, so it is still urgent to find and prepare neutralization antibodies for COVID-19 prevention or treatment. In this study, we created a new strategy to effectively obtain neutralizing antibodies or complementary determining region 3 (CDR3) of neutralizing antibodies against SARS-CoV-2. We first predicted and synthesized several B cell epitopes on RBD and adjacent RBD of S protein, then the B cell epitopes were used to prepare affinity chromatography columns respectively and purify the binding IgG from serum samples of convalescent COVID-19 patients. After these IgGs were identified to have neutralizing activity, the peptide sequences of the antigen-binding regions (variable region) of neutralizing antibodies were analyzed by protein mass spectrometry. Subsequently, the B cells from the same individual were sorted and used to obtain their full BCR repertoire by 5′ RACE combined with high-throughput of PacBio sequencing method. Then, the peptide sequence of neutralizing antibody variable region by protein mass spectrometry was mapped to the full BCR repertoire and found the full variable region sequence of neutralizing antibodies. Finally, we obtained and synthesized numerous CDR3 peptides of neutralizing antibodies to confirm the neutralizing activity for SARS-CoV-2 infection. Our results indicate that the novel scheme will be suitable for rapid screening of neutralizing antibodies, including screening neutralizing antibodies against SARS-CoV-2 and other pathogenic microorganisms.
Application of intervention of information motivation behavior skill (IMB) model in the cardiac rehabilitation of patients with coronary heart disease
Authors: Li Meihua , Zhu Hailing 
Published: July 2022

Objectives: To explore the effects of information motivation behavior skill (IMB) model in the cardiac rehabilitation of patients with coronary heart disease.
Methods: We analyzed data from medical records of patients with coronary heart disease who had received cardiac rehabilitation treatment in the Department of Cardiology of our hospital from April 2019 to May 2021. Data from 52 patients who had received routine nursing rehabilitation (Mode-I) and 56 patients that received IMB model-oriented nursing rehabilitation (Mode-II) was included. We calculated indexes of cardiopulmonary function, physical fitness, and nursing satisfaction, and self-efficacy scores (GSEs) before and three months after the intervention for patients in the two rehabilitation groups.
Results: We found similar LVEFs, SVs, anaerobic thresholds, peak oxygen uptake scores, PEFs, and FVCs in patients undergoing either of the two rehabilitation modes before the interventions (P>0.05). However, these indexes were significantly higher in patients undergoing Mode-II rehabilitation after the intervention, compared to Mode-I group (P<0.05). We found similar aerobic endurances, upper limb and lower limb muscle strengths in patients undergoing either method before the intervention (P>0.05). After the treatment, these parameters were higher in the Mode-II group compared to Mode-I group (P<0.05). The scores of daily life behavior management, cognitive symptom management, and disease management between the two groups were similar before the intervention (P>0.05). After the intervention, patients undergoing Mode-II rehabilitation had significantly higher values than patients in the Mode-I group (P<0.05). The nursing satisfaction of the patients in the Mode-II group (94.64%) was significantly higher than that of patients in the Mode-I group (80.77%) (P<0.05).
Conclusion: IMB model intervention measures can improve cardiopulmonary function and physical fitness, and enhance the patients’ self-efficacy, resulting in high nursing satisfaction.
doi: https://doi.org/10.12669/pjms.38.6.5721
How to cite this:Li M, Zhu H. Application of intervention of information motivation behavior skill (IMB) model in the cardiac rehabilitation of patients with coronary heart disease. Pak J Med Sci. 2022;38(6):1627-1632. doi: https://doi.org/10.12669/pjms.38.6.5721
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
THE STATE OF SOME INDICATORS OF HEMOSTASIS IN RELATIVELY HEALTHY PEOPLE AND PATIENTS WITH ISCHEMIC STROKE, TAKING INTO ACCOUNT GENDER DIFFERENCES
Authors: Masljakov Vladimir V. , Pavlova Ol’ga N. , Foht Julija V. , Abakumova Julija V. , Fedotova Natal’ja N. 
Published: July 2022

Goal. To study some indicators of hemostasis in a comparative aspect in patients with ischemic stroke and healthy people, taking into account gender differences.
Materials and methods. In the course of the study, the hemostasis indices of 160 people were studied. All the examined were divided into two subgroups, the first consisted of 100 donors, 50 men and women each, who did not have acute and chronic diseases. The second group included the study of analogical indicators in 60 people, 30 men and women, with an established diagnosis of acute ischemic cerebral circulation disorder.
Results. As the results show, differences in hemostasis indicators were found, taking into account gender differences, and disorders in the hemostasis system play an important role in the pathogenesis of ischemic stroke. The obtained results suggest that as a result of the development of endothelial tissue dysfunction, the level of endothelin increased, which led to pronounced vascular spasm and increased procoagulant activity of the blood.
Conclusion. Based on the conducted research, it was found that in men and women at the time of admission with ischemic stroke, in comparison with the results obtained from donors without established pathology, changes in red blood parameters and rheological properties of blood are observed in the blood. It should be noted that in the group of female patients, changes in the rheological properties of blood were less pronounced than in the group of male patients.
GDF11 inhibits abnormal adipogenesis of condylar chondrocytes in temporomandibular joint osteoarthritis
Authors: Wang Helin , Shi Yuqian , He Feng , Ye Tao , Yu Shibin , Miao Hui , Liu Qian , Zhang Mian 
Published: July 2022

Aims Abnormal lipid metabolism is involved in the development of osteoarthritis (OA). Growth differentiation factor 11 (GDF11) is crucial in inhibiting the differentiation of bone marrow mesenchymal stem cells into adipocytes. However, whether GDF11 participates in the abnormal adipogenesis of chondrocytes in OA cartilage is still unclear. Methods Six-week-old female mice were subjected to unilateral anterior crossbite (UAC) to induce OA in the temporomandibular joint (TMJ). Histochemical staining, immunohistochemical staining (IHC), and quantitative real-time polymerase chain reaction (qRT-PCR) were performed. Primary condylar chondrocytes of rats were stimulated with fluid flow shear stress (FFSS) and collected for oil red staining, immunofluorescence staining, qRT-PCR, and immunoprecipitation analysis. Results Abnormal adipogenesis, characterized by increased expression of CCAAT/enhancer-binding protein α (CEBPα), fatty acid binding protein 4 (FABP4), Perilipin1, Adiponectin (AdipoQ), and peroxisome proliferator-activated receptor γ (PPARγ), was enhanced in the degenerative cartilage of TMJ OA in UAC mice, accompanied by decreased expression of GDF11. After FFSS stimulation, there were fat droplets in the cytoplasm of cultured cells with increased expression of PPARγ, CEBPα, FABP4, Perilipin1, and AdipoQ and decreased expression of GDF11. Exogenous GDF11 inhibited increased lipid droplets and expression of AdipoQ, CEBPα, and FABP4 induced by FFSS stimulation. GDF11 did not affect the change in PPARγ expression under FFSS, but promoted its post-translational modification by small ubiquitin-related modifier (SUMOylation). Local injection of GDF11 alleviated TMJ OA-related cartilage degeneration and abnormal adipogenesis in UAC mice. Conclusion Abnormal adipogenesis of chondrocytes and decreased GDF11 expression were observed in degenerative cartilage of TMJ OA. GDF11 supplementation effectively inhibits the adipogenesis of chondrocytes and thus alleviates TMJ condylar cartilage degeneration. GDF11 may inhibit the abnormal adipogenesis of chondrocytes by affecting the SUMOylation of PPARγ. Cite this article: Bone Joint Res 2022;11(7):453–464.
Immediate effects of diacutaneous fibrolysis in athletes with hamstring shortening. A randomized within-participant clinical trial
Authors: Cadellans-Arróniz Aïda , López-de-Celis Carlos , Rodríguez-Sanz Jacobo , Pérez-Bellmunt Albert , Labata-Lezáun Noé , González-Rueda Vanessa , Llurda-Almuzara Luis , Rodríguez-Rubio Pere Ramón 
Published: July 2022

Background
Diacutaneous fibrolysis is a non-invasive instrumental physiotherapeutic technique, used to treat mechanical or inflammatory pain and normalize function in the musculoskeletal system. Different studies have reported positive effects on range of motion, strength or function in musculoskeletal disorders, mainly in the upper extremity. The incidence and recurrence rates of hamstring injuries are high in many sports. However, there are no studies assessing these parameters in the hamstring and gluteus maximus in athletes. Objective. To evaluate the immediate and 30 minutes post-treatment effects of a single diacutaneous fibrolysis session on hamstring length, flexibility, muscle strength, myoelectrical activity and lower limb performance in athletes with hamstring shortening.

Methods
A randomized within-participant clinical trial. Sixty-six athletes with hamstring shortening were recruited. A single session of diacutaneous fibrolysis was applied following the cetripetal protocol to the gluteus maximus, biceps femoris and semitendinosus of for the experimental lower limb, whereas the control limb was not treated. Hamstring length (Passive knee extension test), hamstring and low back flexibility (Modified back saver sit and reach test), hamstring and gluteus maximus strength and electrical activity (dynamometry and surface electromyography, respectively) and lower limb performance (Countermovement Jump) were tested before treatment (T0), after treatment (T1), and 30 minutes post-treatment (T2).

Results
We only found a statistically significant difference between T0-T2 for the hamstring length favouring the experimental limbs (p<0.001). There were no statistically significant changes for hamstring and lower back flexibility, strength and electrical activity outcomes between groups. In the countermovement jump, we found a decrease of 0.58 cm in the high jump and a decrease of 9.19 N in the power jump at T1. These values recovered and improved at T2. However, these changes were not statistically significant (p>0.05).

Conclusions
A single session of diacutaneous fibrolysis in athletes with hamstring shortening, following the centripetal protocol for the posterior part of the thigh, produces improvements in hamstring length 30 minutes after, and in gluteus maximus strength immediately and 30 minutes after the treatment. It seems to have no effects on the overall hamstring and lower back flexibility or myoelectric activity. Importantly, the lower limb performance was not impaired after the treatment.
Community-based health insurance, healthcare service utilization and associated factors in South Gondar Zone Northwest, Ethiopia, 2021: A comparative cross-sectional study
Authors: Dagnaw Fentaw Teshome , Azanaw Melkalem Mamuye , Adamu Aytenew , Ashagrie Tinsaea , Mohammed Abdelah Alifnur , Dawid Hiwot Yisak , Tiruneh Mulu , Demissie Biruk , Yemata Getaneh Atikilt , Yitbarek Getachew Yideg , Abebaw Yikeber , Hailemeskel Habtamu Shimels 
Published: July 2022

Introduction
Community-based health insurance schemes are becoming increasingly recognized as a potential strategy to achieve universal health coverage in developing countries. Ethiopia has implemented community-based health insurance in piloted regions of the country. The scheme aims to improve the utilization of healthcare services by removing financial barriers. There is a dearth of literature regarding the effect of the insurance scheme on the utilization of healthcare services.

Methods
A community-based comparative cross-sectional study was conducted in the south Gondar Zone. Six hundred fifty-eight participants were selected using a systematic random sampling method. Data were entered into EPI data version 4.4.1 and exported to SPSS version 25 for analysis. Binary logistic regression was used to measure the association of factors with the outcome variable. The result of the final model was expressed in terms of Adjusted Odd Ratios (AOR) and 95% CI.

Result
Two hundred twenty-three (67.8%) and 111 (33.7%) of the respondents reported that their family members went to health institutions within three months among CBHI users and non-users respectively. The presence of under-five children (AOR = 2, 95% CI = 1.6–2.4), CBHI scheme membership times (AOR = 3, 95% CI = 2.6–3.4), household wealth index rich (AOR = 4, 95% CI = 2.3–6.3), household wealth index medium (AOR = 3, 95% CI = 1.8–5.8) and presence of chronic illness (AOR = 0.5, 95% CI = 0.2–0.8) was associated with health care service utilization. Households who were enrolled in CBHI were more likely to use healthcare services than households who were not enrolled.

Conclusion and recommendation
Households who were enrolled in CBHI were more likely to use healthcare services than households who were not enrolled. Therefore, health sector leaders and managers in the study area should strengthen their efforts for increasing the enrollment of the community into CBHI.