bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytotoxic Activity, and Molecular Docking of Indole Alkaloid Voacangine and Bisindole Alkaloid Vobtusine, Vobtusine Lactone from the Indonesian Plant: Voacanga foetida (Blume) Rolfe
Authors: Susanty Adriani 
Published: January 2022

ABSTRACT
The purpose of this study was to isolate and test its cytotoxic activity starting from extract fraction and its isolate compound, then carried out molecular docking to confirm the potential biological activity of ligands (vocangine, vobtusine, and vobtusine lactone) against inhibition proteins (Bcl-2, Bcl-xL, and Mcl-1), activation protein Bax and activation of apoptotic execution protein Caspase-3. This research is an experimental quantitative study using column chromatography and HPLC methods in the isolation process, MTT assay in determining the cytotoxic activity, and molecular docking in determining the prediction of apoptotic mechanism. The cytotoxic activity of VFB-DA, VFB-DB, VFB-BuOH, VFB-DB4 fractions, voacangine compounds, vobtusine are very strong. while vobtusine lactone is moderate cytotoxic activity. The docking score for voacangine, vobtusine, and vobtusine lactone compounds against Bcl-2 is -9.93; -10.07; -9.03 kcal/mol, against Bcl-xl is -9.77; -11.69; -9.76 kcal/mol, against Mcl-1 is -10.70; -10.77; -9.53 kcal/mol, and for Bax is -8.99; -6.87; -6.99 kcal/mol, as well as against caspase3 is -12.05; -12.21; -12.02 kcal/mol. The cytotoxic activity of voacangine, vobtusine, and vobtusine lactone compounds is thought to cause cell death by suppressing Bcl-2 activity; Bcl-xl; and Mcl-1, increased Bax activity and increased caspase3 activity.

Key words: Voacanga foetida, in vitro, in silico
SYNTHESIS OF CR(III)-ASPARTATE AND CU(II)-ASPARTATE COMPLEXES AS ANTIDIABETIC COMPOUND
Authors: Hadi Sutopo , Ambarwati Yuli , Firguna Dinda S. , Bahri Syaiful , Laila Aspita 
Published: January 2022

The synthesis of Cr(III)-Aspartate and Cu(II)-Aspartate complexes has been successfully conducted by reacting CrCl3·6H2O and CuCl2·2H2O metals with aspartic acid. Therefore, this study aimed to synthesize Cr(Asp)2Cl2 and Cu(Asp)Cl2 as well as test their antidiabetic effects. The synthesis results of Cr(Asp)2Cl2 and Cu(Asp)Cl2 in the form of light purple and blue solids were 0.3001 g and 0.3095g with a yield of 95.14% and 95.02%, respectively. Furthermore, the antidiabetic test used 27 male mice (Mus musculus) with nine treatments for 21 days. The data obtained were analyzed statistically using analysis of variance, and the antidiabetic activity was expressed in percent glucose lowering. The result showed a decrease in blood glucose levels in mice after alloxan induction, with percent glucose lowering (%GL) values of 74.1874% for Cr(Asp)2Cl2 and 76.1337% for Cu(Asp)Cl2 compounds. Therefore, the Cr(Asp)2Cl2 and Cu(Asp)Cl2 compounds can be used as antidiabetic in mice which are also potentially used as metal-based drugs for the treatment of DM.
A Novel Stability Study of Simvastatin Generic Tablet in Public Pharmacy Facilities of Purwakarta District, Indonesia
Authors: Muchtaridi Muchtaridi , Yulianita Rini , Sopyan Iyan , Mohd Gazzali Amirah 
Published: January 2022

Drug stability is one of the most important criteria for producing safe, excellent and effective products. Some environmental factors that influence drug stability are light, temperature, and humidity. Simvastatin is a cholesterol-lowering drug that is known to be sensitive to high temperature and humidity. The purpose of this study is to analyze the effect of 6 months of real-time storage conditions on the stability of generic simvastatin tablets in public pharmacy facilities. This study used simulation method with 4 brands of simvastatin generic tablets with two different strengths (10 mg and 20 mg). In the process, the sample was conditioned in 6 different regions for 6 months. The results of temperature and humidity monitoring showed 2 locations at ≤ 25 ° C, 4 locations had a temperature of ≥ 25 °C and all locations had humidity > 65 %. The drug was evaluated for physical and chemical quality parameters at months 0, 3, and 6. After being stored for 6 months, the tablets showed a decrease in disintegration time and an increase in the friability, showing lack of durability. Similarly, there was a decrease in the content concentration in the tablets but fortunately the level was still within the accepted specification range (90 – 110 %). However, there was one tablet that did not meet the dissolution test requirements after the storage duration (Q ≤ 75 % at 30 minutes). The results of the stress test showed that simvastatin degraded in all conditions. This stress test confirmed the extreme instability of simvastatin. Poor storage conditions can reduce the quality of generic simvastatin tablets, thus a well-controlled environment is vital in pharmacy facilities.
Kestävä kädenjälki käsityössä
Authors: Väänänen Niina , Pöllänen Sinikka 
Published: January 2022

Käsitepari kestävä käsityö on syntynyt käsityön vastaukseksi kestävän kehityksen haasteisiin. Tässä teoreettisessa kirjallisuuskatsauksessa tarkastelemme käsityötä mahdollisuutena kestävään kädenjälkeen. Ensin pohjustamme keskustelua kirjallisuuden avulla, minkä jälkeen syvennymme kestävän käsityön käsitteeseen sekä avaamme näkökulmia kestävään käsityöhön perusopetuksen käsityössä. Kestävän käsityön teoreettisessa mallissa kuvataan käsityötä toimintana, tuotteena ja aineettomana käsityönä. Kestävää käsityötä toimintana kuvataan käsityötietoa syventävänä sekä arvoja ja asenteita muokkaavana taitona. Kestävä käsityötuote puolestaan huomioi materiaalien, elinkaaren, tekniikan, designin, laadun, esteettisyyden, tarpeen ja tuotesuhteen. Aineeton käsityö nivoo kestävyyden ympäristön lisäksi kulttuuriin sekä sosiaaliseen, taloudelliseen, psykologiseen, yhteiskunnalliseen, filosofiseen ja kommunikatiiviseen näkökulmaan. Nämä elementit toimivat lomittain yhdessä muotoillen ympäristöä, konkreettisia tuotteita sekä tekoja kestäväksi ekologiseksi kädenjäljeksi, mikä tulisi olla lähtökohtana myös käsityönopetuksessa kaikilla koulutusasteilla.

Ecological handprint in craft
Abstract
The concept of sustainable craft is crafts’ response to sustainability. This theoretical article views the craft's potential to be an ecological handprint. We first view discussion through literature, followed by opening the concept of sustainable craft and viewpoint to sustainable craft education. The theoretical model concretizes the systemic nature of sustainable craft as practice, product, and immaterial craft. Sustainable craft as practice is described as deepening craft knowledge and as a skill shaping the values and attitudes of craft. Sustainable craft products consider the materials, life cycle, technique, design, quality, aesthetics, need, and product relationship. Immaterial craft combines sustainability to the environment, cultural, social, economic, psychologic, societal, philosophical, and communicational aspects. These elements work together shaping the environment, concrete product, and actions towards sustainability with an ecological handprint that could be utilized in craft education.
Keywords: Immaterial craft, sustainable development, craft product, craft skill, ecological handprint
Kohti yhteiskehittelyä
Authors: Lahti Henna , Davies Sini 
Published: January 2022

Artikkelissa tarkastellaan peruskoulussa toteutettua keksintöprojektia, jonka aikana oppilasryhmä suunnitteli ja toteutti älyvaatteen. Tutkimus on osa laajempaa tutkimushanketta, jossa koulua kehitetään keksivänä ja innovatiivisena yhteisönä. Tässä tutkimuksessa selvitetään, miten oppilasryhmän älyvaatteen suunnittelu- ja valmistusprosessi eteni ja mikä rooli opettajilla oli prosessin aikana. Tutkimusaineisto sisältää yhdeksän opetuskerran videoinnit. Videoaineistoon tehdyn makroanalyysin perusteella kartoitettiin kaikki ne opetustilanteet, joissa ilmeni vuorovaikutusta opettajan ja oppilaiden välillä. Teoriaohjaavaan analyysiin pohjautuen erotellaan ja tulkitaan vuoro-vaikutuksen erilaisia muotoja. Tutkimustuloksissa korostuu opettajan rooli sekä vaatteen yhteiskehittelyssä että oppilaiden toiminnan ohjaamisessa. Yhteiskehittelyn toteutuminen edellyttää riittäviä aika- ja taitoresursseja sekä motivaatiota ratkaista haastavia suunnitteluongelmia.

Towards co-creation: Observations of the teacher's role in the smart clothing project
Abstract
In this article we examined an invention project in a comprehensive school where a group of pupils designed and manufactured a set of smart clothing. The study is a part of a wider research project in which the school is being developed as an inventive and innovative community. In this study we analysed how the design and manufacturing processes of the smart clothing proceeded and what roles the teachers had during the process. The research data comprised video recordings of nine project sessions. All the teaching episodes containing interactions between the teacher and the pupils were surveyed as part of the macro level analysis. Based on the theory-driven analysis, the different forms of the interaction were identified and interpreted. In the results, the nature of the teacher's role emerged in both the co-creation of the smart clothing and in directing the pupils' actions. Successful co-creation requires enough time, skill, and motivation to solve challenging design problems.
Keywords: discovery learning, e-textiles, apparel design, smart clothing
Kohti uutta käsityön oppimis- ja työympäristöä
Authors: Lindfors Eila , Jaatinen Juha , Wendelius Sara , Uljas Miika 
Published: January 2022

Perusopetuksen käsityön oppiaine on uudistunut opetussuunnitelmallisesti ja käsityön oppimis- ja työympäristöjen tilaratkaisut vaativat uudenlaista pohdintaa. Tässä tutkimuksessa tarkastellaan käsityötä opettavien opettajien (N = 11) näkemyksiä heidän omiin kokemuksiinsa perustuen. Näkemyksiä taustoitetaan käsityön suunnittelu- ja valmistusprosessin luonteeseen, fyysisen oppimis- ja työympäristön erityispiirteisiin ja tilasuunnittelun periaatteisiin liittyen. Tilasuunnittelussa suunnitellaan ja toteutetaan fyysistä oppimis- ja työympäristöä lähtökohtaisesti pedagogisen suunnitelman pohjalta. Aineistolähtöiseen sisällönanalyysiin perustuen opettajat tarkastelivat käsityön fyysisen oppimis- ja työympäristön kehittämistä tilasuunnittelun osalta kolmen pääluokan avulla: käsityötilojen rakenne ja sijoittuminen, kalusteet ja välineet sekä opettajien osallisuus ja resurssit tilasuunnittelussa. Tutkimuksen tulokset korostavat opettajien osallistumisen tärkeyttä tilasuunnittelussa sen alkuvaiheista lähtien. Opetussuunnitelma vaihtuu kymmenen vuoden välein, mutta käsityön tilasuunnittelun ratkaisut tehdään vuosikymmeniksi.

Towards new learning and working environments in Craft, Design and Technology education – Teachers' views on planning and construction
Abstract
In Finland the curriculum of subject Craft, Design and Technology (CDT) education is renewed and there is a need to reconsider how to plan and construct learning and working environments in the future. This study bases on the CDT education teachers' views (N = 11) on workspace and workshop planning and construction. The content analysis based on interview data revealed that teachers consider space planning construction as a combination of structure and placement in schools, as a combination of equipment, tools and furniture and their own possibilities to participate in the planning process. It would be very important to invite teachers to be part of a space planning and construction process as early as possible to avoid pedagogically fatal mistakes and problems in construction of physical spaces.
Keywords: learning and working environment, space planning and contruction, craft design and technology education, basic education
Analysis of scientific production on Technological Innovation in Tourism
Authors: Rafael Célia , Pires Ana Luísa 
Published: January 2022

Abstract
Until the emergence of the COVID-19 pandemic, tourism was one of the sectors with the greatest growth potential on a global scale. It is now highlighted as one of the hardest hit sectors in economic terms and requires strategic recovery capacity coupled with technological innovation. Technology and innovation could provide a strong contribution to the development of tourism by integrating knowledge about tourism products, services and experiences and the new needs and behaviours of consumers. This study analysed the scientific productions on technological innovation in the tourism sector using literature review and bibliometric analysis techniques, with data collected from the main databases of international relevance, Web of Science and Scopus. This study presents the mapping and cluster structures for the trends and dynamics of the investigations on the discovered research themes using the VOSviewer software. The results indicate that research related to innovation and technology in tourism has evolved in recent years, as well as highlighting the main areas of activity and presenting contributions to possible future lines of research.
Exploring Solutions and the Role of GDS Technology in Crossing the Current Pandemic Context in Tourism
Authors: Foris Diana , Matei Cristina-Alexandra , Foris Tiberiu 
Published: January 2022

Abstract
In the current pandemic context, tourists increasingly need to receive assurances from the tourism and hospitality industry that their safety and health will not be endangered during their trip or their stay. Tourists increasingly prefer to plan their own trips and information technology is playing a very important role in the hotel and tourism industry. This study uses strategic management methods and comparative analysis to formulate strategies, measures, and solutions to maintain the safety and the health of tourists at the level of the tourism and hospitality industry. The aim of the paper is to provide solutions for the tourism industry in the current context of the COVID-19 pandemic, through a strategic managerial approach and by involving information technology and global distribution systems (GDSs) as a decision supporting tool. The results of the study are useful for small and medium enterprises to act efficiently in this pandemic context, but are also useful for GDS providers to reflect on possible improvements in system functionality to implement solutions and to support the decisions of tourists.
The Role of Micro-Influencers in the Consumer Decision-Making Process in the Hospitality Field
Authors: Peres Rita , Silva Mariana 
Published: January 2022

Abstract
The aim of this research is to understand the role played by social media influencers in consumers’ decision-making processes concerning hotels. To achieve this general objective, the following specific aims were defined: (1) to understand the profile of the micro-influencers that share user generated content (UGC) about hotels and the main networks within which they operate; to this end, a study was made by means of interviews to ascertain the profiles of 16 unpaid micro-influencers who share content about Portuguese hotels, and (2) to adopt the information acceptance model (IACM) put forward by Erkan and Evans (2016), to examine the influence of electronic word of mouth (eWOM) in social media on cosumer's behaviour intention in hotel industry, based on the profile of 166 consumers who follow these micro-influencers. Findings suggest that micro-influencers play a significant role in terms of influencing consumer purchase decision-making in the hospitality area; about 79% of surveyed consumers who follow micro-influencers’ content feel their choice is influenced and consider that the contents shared enable consumers to form an idea of what their stay will be like, due to some of the micro-influencers’ characteristics. The adoption of the IACM model demonstrates that the credibility of eWOM information positively affects the usefulness of the information. However, the quality of eWOM information, needs of eWOM information, and attitudes toward eWOM have a medium effect on the usefulness of eWOM information, but also in the attitudes toward eWOM and usefulness of eWOM in the adoption of eWOM information. The followers’ behavioural intentions are strongly explained by their attitudes toward eWOM information and adoption of eWOM information.
Impact of Mobile Applications in Changing the Tourist Experience
Authors: Dias Sónia , Afonso Victor Alves 
Published: January 2022

Abstract
This exploratory study investigates the impact of technology on the tourist experience. This research analyzed the effect of new technologies on the behaviour of new tourism consumers, the importance of mobile technology in the tourism industry, and the phenomenon of mobile tourism in the change of the tourism experience. It also studied the spillover effect that these changes have had on the use of mobile applications in tourism, trying to understand their impact on the tourism experience. A quantitative and qualitative analysis supported this investigation through a survey of 110 Portuguese tourists using applications and two interviews with administrators of mobile application development companies, and, finally, through the analysis of four case studies. The main conclusion is that smartphones and mobile travel applications can substantially alter the tourist experience. Tourists assume that smartphones have motivated changes in the activities and emotions experienced, especially in social applications that allow them to maintain contact with their friends and families and increase security levels.
Visualization analysis of research “hot spots”: self-management in breast cancer patients†
Authors: Jiang Tong-Tong , Majima Tomoko , Shi Tie-Ying 
Published: January 2022

Abstract

Objective
To identify the research on “hot spots” and frontiers of self-management in patients with breast cancer.

Methods
We searched the Web of Science database for articles associated with keywords, and used CiteSpaceIII to analyze the data.

Results
A total of 958 documents were included. High-frequency keywords covered “quality of life (QOL),” “randomized controlled trial,” “depression,” “fatigue,” and “meta-analysis.” Research on self-management by patients with breast cancer has mainly been conducted in the United States of American (USA) and other western countries, whereas the Asian country, China ranked eighth among the top 10 countries.

Conclusions
The analysis revealed research on “hot spots” particularly research on psychological health and QOL. Promoting clinical research, encouraging evidence-based practice, and developing nursing specialization may improve research on self-management interventions for patients with breast cancer.
Relationship between clinical performance and professional self-concept in critical care nurses
Authors: Eskandari Narges , Abbasi Mohammad , Abbasinia Mohammad , Norouzadeh Reza 
Published: January 2022

Abstract

Objective
To determine the relationship between clinical performance and professional self-concept in critical care nurses.

Methods
This study was conducted on 308 critical care nurses. Data gathering instruments were nurses’ clinical performance questionnaire (NCPQ) and nursing professional self-concept measure (NPSCM). Independent sample t-test, one-way analysis of variance (ANOVA), and Pearson correlation coefficient were used for data analyses.

Results
The average age of the nurses was 33.74 ± 7.01 years. The clinical performance score of female nurses was significantly higher than male nurses. In the domain of clinical performance, clinical judgment and clinical inquiry had the highest and lowest scores, respectively. In the nurses’ professional self-concept, the highest and lowest scores were awarded to the subscales of self-confidence and staff relations, respectively. In addition, there was a significant positive correlation between self-concept and clinical performance of nurses.

Conclusions
Increasing professional self-concept improves the clinical performance of critical care nurses. Professional self-concept enhancement measures are recommended to improve the clinical performance of nurses in critical care units.
Introduction to the second edition of ‘Diagnostic Cytopathology of Serous Fluids’ as CytoJournal Monograph (CMAS) in Open Access
Authors: Shidham Vinod B. , Layfield Lester J. 
Published: January 2022

Serous fluids are excessive accumulation of fluids in a serous cavity as effusion. However, traditionally this area also covers cytopathologic evaluation of washings of these cavities including pelvic/peritoneal washing.
This is the introductory review article in series on this topic with the application of simplified algorithmic approaches. The series would be compiled finally as a book after minor modifications of individual review articles to accommodate the book layout on the topic as second edition of ‘Diagnostic Cytopathology of Serous Fluids’ book.
The approach is primarily directed towards detection of neoplastic cells based on morphology alone or with the help of various ancillary tests, including commonly applied immunocytochemistry to be interpreted as second foreign population with application of SCIP (subtractive coordinate immunoreactivity pattern) approach in effusion fluid tapings. As the role of molecular pathology tests is increasing, this component as ancillary testing will also be covered as applicable. Because a picture and sketches are worth a thousand words, illustrations and figures are included generously even at the risk of moderate repetition.
The clinically important serous cavities include peritoneal cavity, pericardial cavity, and two pleural cavities. The primary topic of this series is specimens from these cavities as effusion fluids and washings including cytopathologic evaluation of peritoneal/pelvic washing.
It is expected that some readers may not read the entire series or the final book from beginning to end, but refer to the individual review articles and chapters sporadically during their clinical practice. Considering this practical limitation, some brief repetition may be observed throughout the book. Some of the important themes will be highlighted as italicized and bolded text for quick reference.
Dedicated articles/chapters are assigned for technical and other reference material as appendices. Tables, algorithms, sketches, and combination of pictures are included generously for quick reference. Most of the illustrations are attempted to be labeled appropriately with arrows and other indicators to avoid equivocation, especially for beginners in the field.
This introductory review article describes general details under the following three broad headings:
Histology and general cytology of serous cavity lining
Effusion (general considerations)
Ancillary techniques in brief.