bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraplatform and Interplatform Competition ——Evidence from E-Commerce Platforms
Authors: Qu Chuang , Liu Hanzhen , Sun Hongfei 
Published: September 2022

Abstract
Based on the essential characteristics of two-sided markets, this paper analyzes the role of competition between users within platforms in the competition between platforms from three aspects: user scale effect, platform stickiness effect and platform competition effect. We found that in the most realistic oligopoly market structure, the effect of platform competition plays a leading role, and competition between users within platforms intensifies competition between platforms. Because ranking competition is a unique competition mode in internet platforms, this paper further investigates the role of ranking positions on platforms’ multiple types of competition. Top-ranked merchants have a strong platform competition effect due to flows and sales volume, which has a positive effect on competition between platforms. However, this effect weakens with the backward-ranking of positions and leads to an overall negative effect. Finally, this study conducts a heterogeneity analysis of different platform modes and shows that the internal market concentration of self-operating e-commerce is significantly more concentrated and that the effect of merchant competition on platform competition is weaker than that of platform e-commerce.
The Predictive Prognosis Score around Primary Debulking Surgery (PPSP) improves diagnostic efficacy in predicting the prognosis of ovarian cancer comparable to FIGO staging
Authors: Kawahara Naoki , Kawaguchi Ryuji , Waki Keita , Maehana Tomoka , Yamanaka Shoichiro , Yamada Yuki , Kimura Fuminori 
Published: September 2022

Abstract
Background: In recent years the pretreatment inflammatory responses have proven to predict the prognosis, but no report exists analyzing the combined inflammatory response both of the pre- and post-surgical treatment. The current study aims to extract the factors predicting the prognosis and create novel predictive scoring.
Methods: This retrospective study was conducted at our institution between November 2006 and December 2020. Demographic and clinicopathological data were collected from women who underwent primary surgical staging. We created the scoring system named the predictive prognosis score around primary debulking surgery(PPSP). Univariate and multivariate analyses were performed to assess its efficacy in predicting progression-free survival(PFS) and overall survival(OS). Cox regression analyses were used to assess its time dependent efficacy. Kaplan-Meier and the log-rank test were used to compare the survival rate.
Results: A total of 235 patients were included in the current study. The cut-off value of the scoring system was six. Multivariate analyses revealed that an advanced International Federation of Gynecology and Obstetrics(FIGO) stage (p<0.001 for PFS; p=0.038 for OS), the decreased white blood cell count difference (p=0.026 for PFS) and the high-PPSP (p=0.004for PFS; p=0.002 for OS) were the independent prognostic factors. Cox regression analysis also supported above results.
Conclusions: The PPSP showed good prognostic efficacy in predicting the ovarian cancer prognosis comparable to FIGO staging.
Assessment of spatial and temporal water quality distribution of Lake Ludas, Serbia
Authors: Horvat Zoltan , Horvat Mirjana , Pastor Kristian 
Published: September 2022

Abstract
This work presents the analysis of both spatial and temporal water quality distribution of Lake Ludas in the Republic of Serbia using water quality data from 2011 to 2018 at three different locations. By including a set of standard methods, the initial 15 water quality parameters were reduced to 7 parameters representative for the upcoming temporal and spatial considerations. The selected parameters were subjected to a series of tests such as spatial and temporal analysis. Principal component analysis (PCA) was employed to present the variation of the measurements most efficiently and identify spatial and temporal tendencies. The PCA was expanded by the utilization of biplots providing a more comprehensive understanding of the measurements. Finally, the overall state of the lake's quality was evaluated using the Canadian Council of Ministers of the Environment Water Quality Index method for each sampling location, both annually and for the overall time interval, and as one representative value for the whole lake. The presented research lead to several conclusions, including the need for more detailed future measurements. It was shown that a reasonable monitoring approach leading to reliable conclusions should include much denser data in space and time. Furthermore, the necessity of three sampling locations remains relevant. In fact, it would be preferred to have a shorter list of monitored variables covering denser time and space data acquisition than having more diverse quality parameter evaluation at fever locations or temporally sporadic measurements.
Addressing diverse learner preferences and intelligences with emerging technologies: Matching models to online opportunities
Authors: Zhang Ke , Bonk Curtis J. 
Published: September 2022

This paper critically reviews various learning preferences and human intelligence theories and models with a particular focus on the implications for online learning. It highlights a few key models, Gardner’s multiple intelligences, Fleming and Mills’ VARK model, Honey and Mumford’s Learning Styles, and Kolb’s Experiential Learning Model, and attempts to link them to trends and opportunities in online learning with emerging technologies. By intersecting such models with online technologies, it offers instructors and instructional designers across educational sectors and situations new ways to think about addressing diverse learner needs, backgrounds, and expectations. Learning technologies are important for effective teaching, as are theories and models and theories of learning. We argue that more immense power can be derived from connections between the theories, models and learning technologies.

Résumé : Cet article passe en revue de manière critique les divers modèles et théories sur les préférences d’apprentissage et l’intelligence humaine, avec un accent particulier sur les implications qui en découlent pour l’apprentissage en ligne. L’article présente quelques-uns des principaux modèles (les intelligences multiples de Gardner, le modèle VAK de Fleming et Mills, les styles d’apprentissage de Honey et Mumford et le modèle d’apprentissage expérientiel de Kolb) et tente de les relier à des tendances et occasions d’apprentissage en ligne qui utilisent les nouvelles technologies. En croisant ces modèles avec les technologies Web, les instructeurs et concepteurs pédagogiques dans les secteurs de l’éducation ou en situation éducationnelle se voient offrir de nouvelles façons de tenir compte des divers besoins, horizons et attentes des apprenants. Les technologies d’apprentissage sont importantes pour un enseignement efficace, tout comme les théories et les modèles d’apprentissage. Nous sommes d’avis qu’en établissant des liens entre les théories, les modèles et les technologies d’apprentissage, il est possible d’obtenir un résultat plus puissant.

This article has been translated to Armenian. Click here for the translation.
Recent Developments in Organic Nanotubes for Drug Delivery
Applications
Authors: Bhabal Manasi , Tiwari Abhishekh , Keshari Hemant , Shelar Uttam , Chaskar Atul Changdev 
Published: September 2022

Abstract:
Over the past few years, nanoparticles have been widely used in therapeutic applications.
It is well acknowledged that nanoparticles have improved the shortcomings of conventional treatments.
The advantages and drawbacks of inorganic nanocarriers such as metal nanoparticles and
quantum dots have been extensively studied. Although carbon nanotubes have been touted as a
prominent medication delivery method, their physicochemical characteristics, such as low water
solubility, limited circulation time, etc., restrict their use. Compared to hard matter tubes like carbon
and other inorganic matter, organic nanotubes have better physiological properties such as
improved blood stability, longer circulation time, high serum solubility, etc. The current study focuses
on recent developments in the use of organic nanotubes for drug delivery and the utilization
of their structural features. The soft, organic material that builds up these nanotubes has a synergistic
effect on biocompatibility and lowers cytotoxicity thus proving suitable for the potential use as
drug delivery carrier. The goals of this review are to identify the characteristics that support the
creation of new drug delivery systems and to shed light on current advancements that have been
reported in the literature. The paper also includes discussion of the difficulties in using these organic
nanotubes for applications in drug delivery as well as the potential for future research in this
field.
HOXA10 Expressing UCMSCs Transplantation Improved Endometrial
Receptivity on Endometrial Injury
Authors: Wu Meixian , Li Yuanyuan , Wang Yiwei , Li Yifan , Li Jinghui , Xie Jing , Zhao Shuang , Sun Lihua 
Published: September 2022

Background:
Endometrial injury is considered the major cause of female infertility. Traditional therapies such as estrogen substitution therapy are not satisfactory due to individual variation in response to treatment, thereby warranting the use of alternative strategies such as stem cell therapy. Transplantation of stem cells, such as umbilical cord mesenchymal stem cells (UCMSCs), has been shown to improve endometrial healing. However, due to the effect of the intrauterine environment, the therapeutic effect of UCMSCs is limited, and its efficacy is unstable. HOXA10, encoded by the HOXA10 gene, plays an important role in endometrium morphology maintenance, proliferation, differentiation, and embryo implantation. Moreover, UCMSCs do not show HOXA10 expression.

Objective:
Our study aimed to evaluate the therapeutic effects of HOXA10-transfected UCMSCs on endometrial injury repair in vivo.

Methods:
First, we established T10-UCMSCs (UCMSCs transfected with HOXA10) for transplantation. To establish the endometrial injury model, we injected 95% ethanol into the uterine cavity and transplanted T10-UCMSCs into the uterine cavity from the cornua uteri. Fourteen days later, uteri were collected for histological and biochemical analysis of endometrial growth and receptivity.

Results:
Our results showed the endometrial receptivity was better in T10-UCMSCs group than in UCMSCs group, suggesting that HOXA10 could enhance the repairing ability of UCMSCs in the endometrium injury repair. More importantly, the fertility test showed that more embryos were implanted in the T10-UCMSCs group.

Conclusion:
Our results suggest that UCMSCs with HOXA10 expressing could improve the therapeutic effects on endometrial injury repairing.
Symptom Burden in Patients on Maintenance Haemodialysis: Magnitude, Associated Factors, Patients’ attitude and Practice
Authors: Denis Georges Teuwafeu , Mbeng Ako Carole-Shennelle , Mahamat Maimouna , Bandolo Victorine Nzana , Acha Mukwelle Karla , Francois Kaze , Gloria Ashuntantang 
Published: September 2022

Background:
Despite the enormous strides in haemodialysis technology and patient care in high-income countries, patients still experience a lot of symptoms which impair their quality of life (QoL). Data on symptom burden is lacking in low-income countries where the haemodialysis population is younger and access to care is limited.

Objectives:
To assess the symptom burden in patients on maintenance haemodialysis, its associated factors, patients’ attitude, and practice.

Materials and Methods:
All consenting patients on maintenance haemodialysis for at least 3 months in 2 referral hospitals in Yaoundé, Cameroon, were screened for symptoms. We excluded patients with dementia or those with acute illness. We used the Dialysis symptom index (DSI) and the modified Subjective Global Assessment tool to assess symptom burden and nutritional status, respectively. We analysed the data using Statistical Package for Social Science (SPSS) 26.0. A dialysis symptom index above the 75th percentile was considered a higher symptom burden.

Results:
we enrolled 181 participants (64.1% males) with a mean ±SD age of 46.46±14.19years. The median (IQR) dialysis vintage was 37[12-67.5] months and 37% (n=67) were on recombinant erythropoietin. All patients experienced at least a symptom with a median (IQR) of 12[8.0 – 16.0] symptoms per patient. Feeling tired/lack of energy (79%, n=143), decreased interest in sex (73.5%, n=133), dry skin (70.2%, n=127), difficulty becoming sexually aroused (62.4%, n=113), worrying (60.2%, n=109), bone/joint pain (56.4%, n=102), feeling nervous (50.8%, n=92), muscle cramps (50.8%, n=92) and dry mouth (50.3%, n=91) were the most frequent symptoms. The median (IQR) DSI severity score was 41[22.5-58.5] with 24.9% (n=45) having a higher symptom burden. Diabetes mellitus (AOR 5.50; CI 4.66-18.28, p=0.005), malnutrition (AOR 17.68; CI 3.02-103.59, p=0.001), poorly controlled diastolic blood pressure (AOR 4.19; CI 1.20-14.62, p=0.025) and less than 2 weekly sessions of dialysis (AOR 9.05, CI 2.83-28.91, p=<0.001) were independently associated with a higher symptom burden. Out of every 10 patients, 3 did not report their symptoms to the physicians with cost concern as the most reason (70.4%, n=38).

Conclusion:
In this young population where access to dialysis is limited, the symptom burden is high (100%). Active screening and management of enabling factors may reduce symptom burden and cost concern is the frequent reason symptoms are not reported to physicians.
Estimation of Human Absorbed Dose of
188Re-Hynic-Bombesin Based on
Biodistribution Data in Rats
Authors: Vosoughi Sara , Salek Nafise , Yousefnia Hassan , Delavari Milad , Reza Aghamiri Seyed Mahmoud , Ranjbar Hassan 
Published: September 2022

Background:
HYNIC – Bombesin (BBN) is a potential peptide for targeted radionuclide therapy in gastrin-releasing peptide receptor (GRPr)-positive malignancies. The 188Re-HYNIC-BBN is a promising radiopharmaceutical for use in prostate cancer therapy.

Objective:
The aim of this study was to estimate the absorbed dose due to 188Re-HYNIC-BBN radio-complex in human organs based on bio-distribution data of rats.

Methods:
In this research, using bio-distribution data of 188Re-HYNIC-BBN in rats, its radiation absorbed dose of the adult human was calculated for different organs based on MIRD dose calculation method.

Results:
A considerable equivalent dose amount of 188Re-Hynic-BBN (0.093 mGy/MBq) was accumulated in the prostate. Moreover, all other tissues except for the kidneys and pancreas approximately received insignificant absorbed dose.

Conclusion:
Since the acceptable absorbed dose for the complex was observed in the prostate, 188Re-Hynic-Bombesin can be regarded as a new potential agent for prostate cancer therapy.
Interpenetrating Polymer Networks of Polyacrylamide with Polyacrylic
and Polymethacrylic Acids and Their Application for Modified Drug
Delivery - a Flash Review
Authors: Simeonov Marin , Kostova Bistra , Vassileva Elena 
Published: September 2022

Abstract:
Polyacrylic and polymethacrylic acids in combination with polymers such as polyacrylamide provide the ability for controlled and sustained drug delivery since they represent pH- and temperature responsiveness. In addition, the synthesis techniques can be used to develop a higher level of supramolecular structures as the interpenetrating polymer networks – as bulk hydrogels or micro-/nanogels. They can provide the opportunity to organize and build up state-of-the-art carriers for different types of drugs thus providing ability to control their loading capacity and drug release performance. This flash review aims to summarize the efforts for synthesis of such interpenetrating polymer networks, their properties and to demonstrate the authors contributions into this field.
An Exploration of Herbal Extracts Loaded Phyto-phospholipid Complexes (Phytosomes) Against Polycystic Ovarian Syndrome: Formulation Considerations
Authors: Tiwari Gaurav , Tiwari Ruchi , Sharma Shubham , Ramachandran Vadivelan 
Published: September 2022

Background:Herbal preparations with low oral bioavailability have a fast first-pass metabolism in the gut and liver. To offset these effects, a method to improve absorption and, as a result, bioavailability must be devised.Objective:The goal of this study was to design, develop, and assess the in vivo toxicity of polyherbal phytosomes for ovarian cyst therapy.Methods:Using antisolvent and rotational evaporation procedures, phytosomes containing phosphatidylcholine and a combination of herbal extracts (Saraca asoca, Bauhinia variegata, and Commiphora mukul) were synthesized. For a blend of Saraca asoca, Bauhinia variegata, and Commiphora mukul, Fourier-transform infrared spectroscopy (FTIR), preformulation investigations, qualitative phytochemical screening, and UV spectrophotometric tests were conducted. Scanning electron microscopy (SEM), zeta potential, ex vivo release, and in vivo toxicological investigations were used to examine phytosomes.Results:FTIR studies suggested no changes in descriptive peaks in raw and extracted herbs although the intensity of peaks slightly reduced. Zeta potential values between -20.4 mV to -29.6 mV suggested stable phytosomes with accepted particle size range. Percentage yield and entrapment efficiency were directly corelated to amount of phospholipid used. Ex vivo studies suggested that the phytosomes with low content of phospholipids showing good permeation profiles. There was no difference in clinical indications between the extract-loaded phytosomes group and the free extract group in in vivo toxicological or histopathological examinations.Conclusion:The findings of current research work suggested that the optimized phytosomes based drug delivery containing herbal extracts as bioenhancers have the potential to improve bioavailability of hydrophobic extracts.
A Video-Delivered Family Therapeutic Intervention for Perinatal Women With Clinically Significant Depressive Symptoms and Family Conflict: Indicators of Feasibility and Acceptability
Authors: Cluxton-Keller Fallon , Hegel Mark T 
Published: September 2022

Background
Variation in family therapeutic intervention fidelity has an impact on outcomes. The use of video conferencing technology can strengthen therapist fidelity to family therapeutic interventions.

Objective
This article explores indicators of feasibility and acceptability for a video-delivered family therapeutic intervention for perinatal women with depressive symptoms and family conflict. The objectives of this article are to describe indicators of feasibility, including therapist fidelity to the intervention and technological factors that relate to implementation of the intervention, as well as indicators of acceptability for participants of the intervention.

Methods
The data included in this article are from an ongoing randomized trial of the Resilience Enhancement Skills Training (REST) video-delivered family therapeutic intervention. Participant recruitment and data collection are still underway for this clinical trial. Of the 106 participants who are currently enrolled in this study, 54 (51%) have been randomized to receive REST from May 2021 through July 2022. Currently, 2 therapists are delivering the intervention, and the training procedures for therapists are summarized herein. Therapist fidelity to the family therapeutic intervention was assessed in 67 audio recorded sessions. The training procedures were summarized for use of video conferencing technology by therapists and the 54 study participants. Knowledge of the video conferencing technology features was assessed in therapists and study participants by the number of attempts required to use the features. Participant responsiveness to the intervention was assessed by the percentage of attended sessions and percentage of complete homework assignments.

Results
To date, both therapists have demonstrated high fidelity to the family therapeutic intervention and used all video conferencing technology features on their first attempt. The current participants required 1 to 3 attempts to use 1 or more of the video conferencing technology features. About 59% (n=32) of the current participants immediately accessed the features on the first attempt. Our results show that perinatal women attended all sessions, and their family members attended 80% of the sessions. To date, participants have completed 80% of the homework assignments.

Conclusions
These early findings describe indicators of the feasibility and acceptability of the video-delivered family therapeutic intervention for use with this high priority population. Upon completion of recruitment and data collection, a subsequent article will include a mixed methods process evaluation of the feasibility and acceptability of the video-delivered family therapeutic intervention.

Trial Registration
ClinicalTrials.gov NCT04741776; https://clinicaltrials.gov/ct2/show/NCT04741776
Comparison of 2021 CKD-EPI Equations for Estimating Racial Differences in Preemptive Waitlisting for Kidney Transplantation
Authors: Ku Elaine , Amaral Sandra , McCulloch Charles E. , Adey Deborah B. , Li Libo , Johansen Kirsten L. 
Published: September 2022

Background and objectives
Wait time for kidney transplantation can accrue when GFR is ≤20 ml/min. We examined whether using the race-free 2021 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations to guide preemptive waitlisting could attenuate racial differences in accruable preemptive wait time.

Design, setting, participants, & measurements
Our retrospective cohort study included Black or White Chronic Renal Insufficiency Cohort (CRIC) participants who were theoretically eligible for waitlist registration. We used Weibull accelerated failure time models to determine the association between race (Black or White) and time to kidney failure from the qualifying visit when the eGFR by creatinine or creatinine-cystatin C 2021 CKD-EPI equations fell to ≤20 ml/min per 1.73 m2. We then tested for differences in the time ratios from models using the 2021 creatinine- or creatinine-cystatin C–based CKD-EPI equation through a bootstrapping approach.

Results
By the creatinine equation, 472 CRIC participants were theoretically eligible for waitlist registration, and potential preemptive wait time was similar for Black versus White participants (time ratio, 1.05; 95% confidence interval, 0.81 to 1.35). The median wait time by the creatinine equation that could be accrued for Black participants was 23 versus 22 months in White participants. By the creatinine-cystatin C equation, 441 CRIC participants were eligible, and potential wait time was 20% shorter (95% confidence interval, 0.62 to 1.02) for Black than White participants. The median wait time that could be accrued for Black participants was 21 versus 26 months for White participants when using the creatinine-cystatin C equation. Using bootstrapping, the ratio of the time ratio of the models using the creatinine versus creatinine-cystatin C equation was statistically significantly different (ratio of the time ratios = 1.31 with 95% confidence interval, 1.06 to 1.62).

Conclusions
Use of the 2021 creatinine-based CKD-EPI equation to determine preemptive waitlist eligibility reduced racial differences in preemptive wait time accrual more than use of the creatinine-cystatin C 2021 CKD-EPI equation within a theoretical context.