bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing patient navigation programs: Considerations and lessons learned from the Alliance to Advance Patient‐Centered Cancer Care
Authors: Ver Hoeve Elizabeth S. , Simon Melissa A. , Danner Sankirtana M. , Washington Antonio J. , Coples Susan D. , Percac‐Lima Sanja , Whited Emma C. , Paskett Electra D. , Naughton Michelle J. , Gray Darrell M. , Wenzel Jennifer A. , Zabora James R. , Hassoon Ahmed , Tolbert Elliott E. , Calhoun Elizabeth , Barton Debra L. , Friese Christopher R. , Titler Marita G. , Hamann Heidi A. 
Published: May 2022

BackgroundSix multidisciplinary cancer centers were selected and funded by the Merck Foundation (2017‐2021) to collaborate in the Alliance to Advance Patient‐Centered Cancer Care (“Alliance”), an initiative to improve patient access, minimize health disparities, and enhance the quality of patient‐centered cancer care. These sites share their insights on implementation and expansion of their patient navigation efforts.MethodsPatient navigation represents an evidence‐based health care intervention designed to enhance patient‐centered care and care coordination. Investigators at 6 National Cancer Institute‐designated cancer centers outline their approaches to reducing health care disparities and synthesize their efforts to ensure sustainability and successful transferability in the management of patients with cancer and their families in real‐world health care settings.ResultsInsights are outlined within the context of patient navigation program effectiveness and supported by examples from Alliance cancer center sites: 1) understand the patient populations, particularly underserved and high‐risk patients; 2) capitalize on the existing infrastructure and institutional commitment to support and sustain patient navigation; and 3) build capacity by mobilizing community support outside of the cancer center.ConclusionsThis process‐level article reflects the importance of collaboration and the usefulness of partnering with other cancer centers to share interdisciplinary insights while undergoing intervention development, implementation, and expansion. These collective insights may be useful to staff at other cancer centers that look to implement, enhance, or evaluate the effectiveness of their patient navigation interventions.
Multidisciplinary integrated care pathway for von Hippel–Lindau disease
Authors: Wolters Wendy P. G. , Dreijerink Koen M. A. , Giles Rachel H. , van der Horst‐Schrivers Anouk N. A. , van Nesselrooij Bernadette , Zandee Wouter T. , Timmers Henri J. L. M. , Seute Tatjana , de Herder Wouter W. , Verrijn Stuart Annemarie A. , Kilic Emine , Brinkman Willem M. , Zondervan Patricia J. , Vandertop W. Peter , Daniels Anthony B. , Wolbers Tijmen , Links Thera P. , van Leeuwaarde Rachel S. 
Published: May 2022

BACKGROUNDClinical pathways are care plans established to describe essential steps in the care of patients with a specific clinical problem. They translate (inter)national guidelines into local applicable protocols and clinical practice. The purpose of this article is to establish a multidisciplinary integrated care pathway for specialists and allied health care professionals in caring for individuals with von Hippel–Lindau (VHL) disease.METHODSUsing a modified Delphi consensus‐making process, a multidisciplinary panel from 5 Dutch University Medical Centers produced an integrated care pathway relating to the provision of care for patients with VHL by medical specialists, specialized nurses, and associated health care professionals. Patient representatives cocreated the pathway and contributed quality criteria from the patients' perspective.RESULTSThe panel agreed on recommendations for the optimal quality of care for individuals with a VHL gene mutation. These items were the starting point for the development of a patient care pathway. With international medical guidelines addressing the different VHL‐related disorders, this article presents a patient care pathway as a flowchart that can be incorporated into VHL expertise clinics or nonacademic treatment clinics.CONCLUSIONSMedical specialists (internists, urologists, neurosurgeons, ophthalmologists, geneticists, medical oncologists, neurologists, gastroenterologists, pediatricians, and ear‐nose‐throat specialists) together with specialized nurses play a vital role alongside health care professionals in providing care to people affected by VHL and their families. This article presents a set of consensus recommendations, supported by organ‐specific guidelines, for the roles of these practitioners in order to provide optimal VHL care. This care pathway can form the basis for the development of comprehensive, integrated pathways for multiple neoplasia syndromes.
COVID‐19: Machine learning for safe transportation
Authors: Sankari Subbiah , Varshini Subramaniam Sankaran , Aafia Shifana Savvas Mohamed 
Published: May 2022

AbstractEntire world has been affected by Covid‐19 pandemic. In fighting against the Covid‐19, social distancing and face mask have a paramount role in freezing the spread of the disease. People are asked to limit their interactions with each other, to reduce the spread of the disease. Here an alert system has to be maintained to caution people traveling in vehicles. Our proposed solution will work primarily on computer vision. The video stream is captured using a camera. Footage is processed using single shot detector algorithm for face mask detection. Second, YOLOv3 object detection algorithm is used to detect if social distancing is maintained or not inside the vehicle. If passengers do not follow the safety rules such as wearing a mask at any point of the time in the whole journey, alarm/alert is given via buzzer/speaker. This ensures that people abide by the safety rules without affecting their daily norms of transportation. It also helps the government to keep the situation under control.
IoT‐TDMA: A performance evaluation ofTDMAscheme for wireless sensor networks with Internet of Things
Authors: Kosunalp Selahattin , Kaya Yunus 
Published: May 2022

AbstractThis article focuses on the design and implementation of an improved version of TDMA scheme for wireless sensor networks (WSNs) exploiting the Internet of Things (IoT) phenomena. The main motivation behind this work is to create an environment for WSNs to benefit from IoT opportunities. An extensive review of the state‐of‐the‐art medium access control (MAC) approaches proposed for IoT is carried out underlying their basic principles and features. An adaptation of TDMA strategy, called IoT‐TDMA, is proposed to enhance the channel performances particularly throughput and latency. To test the performance of IoT‐TDMA practically, a low‐cost node hardware with the capability of Internet connection is essentially designed. IoT‐TDMA has been implemented on real‐world highly scalable single‐hop and multi‐hop topologies. Performance results indicate significant improvements in terms of channel throughput and end‐to‐end delay in comparison to a recently proposed efficient MAC scheme.
A narrative review of psychological theories of post‐traumatic stress disorder, voice hearing, and other psychotic symptoms
Authors: Strachan Laura P. , Paulik Georgie , McEvoy Peter M. 
Published: May 2022

AbstractBackgroundMost voice hearers report childhood trauma. Many voice hearers report comorbid post‐traumatic stress symptoms and that the content of their voices (auditory verbal hallucinations) is directly (voices repeat phrases spoken by perpetrators) or indirectly (voice content and trauma is thematically similar) related to their trauma. The factors that maintain trauma‐related voices are unknown, and there is limited research in this area. This study aimed to identify potential maintaining factors of trauma‐related voices by reviewing models of post‐traumatic stress disorder (PTSD) and positive symptoms of psychosis.MethodModels of PTSD and positive symptoms were reviewed to identify potential factors that are unique and common to both sets of symptoms.ResultsWe reviewed 10 models of PTSD, 4 models of positive symptoms, and 2 trauma‐informed models of voice hearing. One model provided a theoretical explanation of different types of trauma‐related voices. Twenty‐one factors were extracted from 16 theoretical models. No existing model incorporated all these factors.DiscussionExisting PTSD and positive symptom models present a range of common and unique factors. There may be value in extending existing integrative models to include a broader range of potential factors that could explain different pathways to, and expressions of, trauma‐related voices. A future research agenda is presented to investigate how such an extension could lead to more complete individualized case formulations and targeted treatments.
Does periodontitis influence the risk of COVID‐19? A scoping review
Authors: Ghosh Arunibha , Joseph Betsy , Anil Sukumaran 
Published: May 2022

AbstractObjectiveResearch has shown that the novel severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) significantly influences the oral microbiome to expedite systemic diseases by invading harmful oral pathogens near and distant organs. To identify, explore, and map the possible mechanisms underlying periodontitis in severe coronavirus disease 2019 (COVID‐19) cases.Material and MethodsRelevant articles published from December 2019 to February 2022 were identified and screened using keywords and inclusion criteria from various databases.ResultsThis review sheds light on multiple pathways of periodontitis, the spread of periodontal infection and microbial metabolites to the lungs, and the dysregulated immune system with elevated cytokines, reactive oxygen species generation, nuclear DNA damage, and senescence, which have the potential to promote stronger viral attachment to host cells and the onset of COVID‐19 manifestation with increased severity and risk of mortality. In addition, the cytokine connection to SARS‐CoV‐2, T‐cell responses against periodontitis, its connection with COVID‐19, the role of host factors, and periodontal therapy have been discussed.ConclusionsThe relationship between COVID‐19 and periodontitis needs further investigation along with the development of alternative therapies to prevent periodontitis for better management and control of COVID‐19.
A 200 kW high‐efficiency and high‐power density xEV motor controller based on discrete SiC MOSFET devices
Authors: Wang Zhenmin , Luo Bende , Zhan Jinhua , Zhou Hao , Zhan Xubiao , Li Tao , Ye Chunxian , Tian Jiyu 
Published: May 2022

AbstractAs one significant component of the Electric‐Driven System of xEV (all types of electric vehicles), motor controllers have been widely applied and researched. However, the performance of controllers based on Si IGBT is limited due to the characteristics of semiconductors, while the volume and weight of SiC MOSFET modules limit the power density of controllers. Therefore, a scheme for motor controllers based on paralleled discrete SiC MOSFET devices is exhibited in this paper. First, the paper analyzes the current sharing problem of paralleled devices, which is a critical problem limiting the efficiency and power density of the controller. Furthermore, according to the analysis results, a comprehensive optimized scheme for motor controller design is proposed from three aspects of device parameter selection, circuit symmetrical layout, and spatial structure design. The design effectively improves the power density and efficiency of the controller. Finally, this paper carries out simulation analysis and mechanical back‐to‐back tests based on an actual prototype, verifying the effectiveness of the proposed scheme. The test results show that the rated power of the motor controller is up to 200 kW, the power density is more than 50 kW/L (and 50 kW/kg), and the peak efficiency is up to 99.3%.
LncRNA HOXA11‐AS promotes vascular endothelial cell injury in atherosclerosis by regulating the miR‐515‐5p/ROCK1 axis
Authors: Gao Feng , Wang Xiao‐Chen , Luo Zhi‐Dan , Hu Guang‐Quan , Ma Meng‐Qing , Liang Yi , Xu Bang‐Long , Lin Xian‐He 
Published: May 2022

AbstractAimsLong non‐coding RNA HOXA11‐AS participated in heart disease. In this study, we aim to evaluate the potential roles of HOXA11‐AS in atherosclerosis and its underlying mechanisms.Methods and resultsThe expression levels of HOXA11‐AS in ox‐LDL‐treated HUVECs and arch tissues of high‐fat diet‐fed ApoE−/− mice (n = 10) were assessed by qRT‐PCR. The effects of HOXA11‐AS knockdown on the development of atherosclerosis were evaluated using in vitro and in vivo models. Luciferase reporter and RNA immunoprecipitation (RIP) assays verified the potential relationships between HOXA11‐AS or ROCK1 and miR‐515‐5p. The interactive roles between HOXA11‐AS and miR‐515‐5p and between miR‐515‐5p and ROCK1 were further characterized in ox‐LDL‐treated HUVECs. Our data showed that HOXA11‐AS was significantly up‐regulated (P < 0.001), whereas miR‐515‐5p was dramatically down‐regulated in AS mice tissues (P < 0.001) and ox‐LDL‐treated HUVECs (P < 0.01). Ox‐LDL could induce endothelial injuries by inhibiting cell proliferation (P < 0.001) and SOD synthesis (P < 0.001), promoting apoptosis (P < 0.01), ROS (P < 0.001), and MDA production (P < 0.001), increasing Bax (P < 0.001) and cleaved Caspase‐3 (P < 0.001), and decreasing Bcl‐2 (P < 0.001) and phosphorylated eNOS (P < 0.01). HOXA11‐AS knockdown attenuated endothelial injuries via increasing eNOS phosphorylation. Luciferase assay and RIP results confirmed that miR‐515‐5p is directly bound to HOXA11‐AS and ROCK1. HOXA11‐AS promoted ox‐LDL‐induced HUVECs injury by directly inhibiting miR‐515‐5p from increasing ROCK1 expression and subsequently decreasing the expression and phosphorylation of eNOS. MiR‐515‐5p mimics could partially reverse the effects of HOXA11‐AS knockdown.ConclusionsHOXA11‐AS contributed to atherosclerotic injuries by directly regulating the miR‐515‐5p/ROCK1 axis. This study provided new evidence that HOXA11‐AS might be a candidate for atherosclerosis therapy.
The double anaerobic threshold in heart failure: MECKI score database overview
Authors: Rovai Sara , Zaffalon Denise , Cittar Marco , Felli Luca Francesco , Salvioni Elisabetta , Galotta Arianna , Mattavelli Irene , Carriere Cosimo , Mapelli Massimo , Merlo Marco , Vignati Carlo , Sinagra Gianfranco , Agostoni Piergiuseppe 
Published: May 2022

AbstractAimsIn heart failure (HF), anaerobic threshold (AT) may be indeterminable but its value held a relevant prognostic role. AT is evaluated joining three methods: V‐slope, ventilatory equivalent, and end‐tidal methods. The possible non‐concordance between the V‐slope (met AT) and the other two methods (vent AT) has been highlighted in healthy individuals and named double threshold (DT).Methods and resultsWe reanalysed 1075 cardiopulmonary exercise tests of HF patients recruited in the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score database. We identified DT in 43% of cases. Met AT precedes vent AT being met–ventΔVO2 221 (interquartile range: 129–319) mL/min. Peak VO2, 1307 ± 485 vs. 1343 ± 446 mL/min (63 ± 17 vs. 63 ± 17 percentage of predicted), was similar between DT+ and DT− patients. Differently, DT+ showed a lower ventilatory vs. carbon dioxide production (VE/VCO2) slope (29.6 ± 6.1 vs. 31.0 ± 6.3), a lower peak exercise end‐tidal oxygen tension (PetO2) 115.3 (111.5–118.9) vs. 116.4 (112.4–120.2) mmHg, and a higher carbon dioxide tension (PetCO2) 34.2 (30.9–37.1) vs. 32.4 (28.7–35.5) mmHg. Vent AT showed a significant higher VO2, 957 ± 318 vs. 719 ± 252 mL/min, VCO2, 939 ± 319 vs. 627 ± 226 mL/min, ventilation, 31.0 ± 8.3 vs. 22.5 ± 6.3 L/min, respiratory exchange ratio, 0.98 ± 0.08 vs. 0.87 ± 0.07, PetO2, 108 (104–112) vs. 105 (101–109) mmHg, PetCO2, 37 (34–40) vs. 36 (33–39) mmHg, and VE/VO2 ratio, 33.5 ± 6.7 vs. 32.6 ± 6.9, but lower VE/VCO2 ratio, 33 (30–37) vs. 36 (32–41), compared with met AT. At 2 year survival by Kaplan–Meier analysis, even adjusted for confounders, DT resulted not associated with survival.ConclusionsDouble threshold is frequently observed in HF patients. DT+ is associated to a decreased ventilatory response during exercise.
Indanone‐Based Copper(II) Molecular Materials as Potential Semiconductors for Optoelectronic Devices
Authors: Sánchez Vergara María Elena , Monzón‐González César R. , Gómez Gómez Mariana , Salcedo Roberto , Corona‐Sánchez Ricardo , Toscano Rubén A. , Álvarez Toledano Cecilio 
Published: May 2022

AbstractA series of copper(II) molecular materials derived from 2‐benzylidene‐1‐indanones were synthesized in order to investigate the influence of their structure on their optical and semiconductor behavior. The molecular materials were structurally characterized by IR spectroscopy, mass spectrometry, and X‐ray diffraction. Additionally, thin films of copper complexes were successfully deposited by thermal evaporation, and the optical and electrical features of films were examined using UV‐vis spectroscopy and current‐voltage measurements, respectively. Subsequently, the structures of copper(II) complexes were optimized by density functional theory (DFT), and the energy values of the single occupied molecular orbital (SOMO) and lowest unoccupied molecular orbital (LUMO) were calculated. According the DFT calculations, the copper complexes show fluxional isomerism. Theoretical bandgap values were found to be consistent with those experimentally obtained and showed to be closely related with the p‐semiconductor behavior of copper complexes, which at the same time depends on the substituents in the structure.
Nanomagnet Bioconjugates with anti‐CRP Polyclonal Antibodies as Nanobioprobes for Enhanced Impedimetric Detection of CRP
Authors: Adesina Abiola , Adeniyi Omotayo , Mashazi Philani 
Published: May 2022

AbstractSelective purification of biological materials for their detection in complex sample matrix is a general challenge for many researchers working in the field of diagnostics. Magnetic nanoparticles functionalized with biological molecules that impart biomolecular selectivity are therefore of major interest as capture probes thus allowing for magnetic separations. Nanoparticles can also be used for the enhanced detection of biomarkers. In this work, an ultrasensitive sandwich‐based impedimetric immunosensor was fabricated for the detection of C‐reactive protein antigen (CRPAg). Stable and oriented immobilization of anti‐CRP monoclonal antibody was achieved onto electrografted phenylethylamine derivatized with succinic anhydride and phenylboronic acid via carbodiimide chemistry. The detection of CRPAg was achieved using Electrochemical Impedance Spectroscopy (EIS). The enhancement of the impedance charge‐transfer resistance (RCT) signal was achieved using the sandwich approach. The anti‐CRP polyclonal antibody was immobilized in an oriented manner onto magnetic nanoparticles functionalized with phenylboronic acid. The increase in the change in charge‐transfer resistance (ΔRCT) values was linearly proportional to the concentration of CRPAg in the range 10 to 200 ng mL−1 covering the clinical range for CRPAg detection and with a detection limit of 0.34 ng mL−1.
Performance assessment of a 10 kW pressurized solid oxide fuel cell integrated with glycerol supercritical water reforming
Authors: Patcharavorachot Yaneeporn , Chatrattanawet Narissara , Saebea Dang , Arpornwichanop Amornchai 
Published: May 2022

SummaryIn this work, the integrated system of pressurized solid oxide fuel cell (SOFC) and supercritical water reforming of glycerol was proposed. The syngas from the reforming process has high temperature and pressure and thus, it can be used as fuel for the SOFC. The performance of an integrated system was determined through the Aspen Plus simulator in which the electrochemical equations were also included. The developed model was employed to examine the performance of the integrated system with respect to the wider ranges of operation of the reformer and SOFC. In this work, the desired power output of an SOFC stack is set as 10 kW and thus, the area of an SOFC is determined. A smaller area is required as it normally leads to a lower fabrication cost for the SOFC. The simulation results revealed that the smallest SOFC area can be provided when the reformer is operated at 800°C and 240 atm with a ratio of supercritical water to glycerol as 50 whereas the SOFC operation is at 900°C and 4 atm with the current density as 7000 A/m2. Under these operating conditions, the integrated system can provide the cell voltage, required area, fuel utilization, and SOFC efficiency as 1 V, 1.42 m2, 75% and 61%, respectively. From the exergy analysis, it was found that the compressor, heater, and turbine are the highest exergy destruction units whereas the reformer has the lowest exergy destruction, followed by the SOFC stack.
Synthesis and characterization of cellulose hydrogel/graphene oxide/polyaniline composite for high‐performing supercapacitors
Authors: Ben Hadj Said Marwa , Charradi Khaled , Ahmed Zakarya , Cachet Hubert , Debiemme‐Chouvy Catherine , Alsulami Qana A. , Boufi Sami , Keshk Sherif M. A. S. , Chtourou Radhouane 
Published: May 2022

SummaryWe have synthesized a ternary composite electrode comprising graphene oxide (GO), cellulose hydrogel, and polyaniline (PANi). The composite deposited on a platinum electrode was electrochemically characterized. It was investigated using cyclic voltammetry, galvanostatic charge‐discharge, and electrochemical impedance spectroscopy. The ternary composite electrode showed significantly enhanced cycling stability and improved a real capacitance of 980 F g−1 at 10 mV indicating a synergistic effect of cellulose hydrogel on PANi‐GO. We believe the results of this study provide a strong experimental basis for the functioning of supercapacitors.Highlights
A cellulose hydrogel/GO/PANi composite was synthesized using the polymerization method.
Cellulose hydrogel is crucial for the functioning of the composite.
Cellulose hydrogel composite exhibits superior performances.