bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipoprotein(a) concentration and the blood content of INFγ-producing T-helpers 17 (Th17/1) in males with premature coronary artery disease
Authors: Filatova A. Yu. , Afanasieva O. I. , Arefieva T. I. , Klesareva E. A. , Tyurina A. V. , Ezhov M. V. , Pokrovsky S. N. 
Published: July 2022

Aim. To analyze the relationship of blood lipid profile parameters, including the level of lipoprotein(a) (Lp(a)), and the content of circulating CD4+ T-lymphocytes with premature coronary artery disease (CAD).Material and methods. This retrospective cross-sectional study included 76 men aged 40 to 79 years. Patients were divided into following groups: main group — patients with CAD (58 [54;64] years, n=56) onset before the age of 55; control group — patients (62 [57;66] years, n=20) without CAD and obstructive CAD and peripheral arterial disease. Statins were taken by 51 (91%) and 9 (45%) patients in the main and control groups, respectively. In serum and plasma samples, lipid spectrum parameters and Lp(a) concentration were determined. Cellular phenotyping was performed by direct immunofluorescence in a culture of mononuclear leukocytes isolated from blood. To determine cytokines, cells were in vitro activated with inhibitor of intracellular transport of secretory proteins. Cell fluorescence was determined using flow cytometry.Results. Patients of both groups were comparable in age, body mass index, prevalence of hypertension and diabetes. Blood Lp(a) concentrations were higher in the CAD group than in the control group (49 [10;102] mg/dL vs 12 [4,3;32] mg/ dL, p<0,05). The content of INFγ-producing T-helpers 17 (Th17/1) was also higher in the CAD group (19 [15;24] vs 13 [11;22], % of Th17, p=0,05). Logistic regression revealed that elevated Lp(a) levels (≥30 mg/dL) and relative amounts of Th17/1 (>14% of Th17) independently of each other, atherogenic lipoprotein cholesterol levels, classical risk factors, and statin use were associated with premature CAD in the general group of patients with odds ratio (OR) of 4,6 (95% confidence interval (CI), 1,1-20,2) and 10,9 (2,1-56,7), p<0,05, respectively. The combination of Lp(a) >30 mg/dl and Th17/1 over 14% significantly increased the risk of premature CAD (OR, 28,0, 95% CI, 4,31-181,75, p=0,0005).Conclusion. We have shown for the first time that an increased Lp(a) concentration with an increased Th17/1 content is associated with the premature CAD in men.
Oxidative and antioxidant changes in blood of young people with premature coronary artery disease and abdominal obesity
Authors: Polonskaya Ya. V. , Kashtanova E. V. , Stakhneva E. M. , Shramko V. S. , Sadovsky E. V. , Stryukova E. V. , Ragino Yu. I. 
Published: July 2022

Aim. To study the oxidative and antioxidant blood profile in young people with premature coronary artery disease (CAD) and abdominal obesity (AO).Material and methods. The study included 169 people. The main group consisted of 47 patients diagnosed with premature (<45 years of age) CAD, while 22 of them with AO and 25 without AO. The control group included 122 people without CAD, comparable with the main group in sex, age and body mass index. Among them, there are 67 people with AO and 55 people without AO. In all examined patients, the blood levels of total cholesterol, triglycerides, high-density lipoprotein cholesterol, MDA-modified oxidized high-density lipoprotein, superoxide dismutase (SOD), glutathione peroxidase 1, and whole blood total antioxidant capacity (TAC) were determined. Statistical processing was carried out in the SPSS 13.0 program.Results. The blood TAC was 2,3 times lower in persons with CAD than in those without CAD, and amounted to 1,58 mmol of trolox. The blood level of SOD in patients with CAD was 1,16 times higher than in the group of people without CAD. The relative odds of premature CAD were associated with decreased TAC (B=-2,855; Exp(B)=0,058; 95% confidence interval (CI), 0,008-0,392; p=0,004) and increased level of SOD (B=0,105; Exp(B)=1,076; 95% CI, 1,031-1,196; p=0,006), regardless of sex, age, risk factors. Conclusion. Thus, an increased SOD and reduced TAC can be potential biomarkers for premature CAD in people under 45 years of age.
Prognostic value of subclinical atherosclerosis in patients with a SCORE risk <5%: data from a 10-year follow-up
Authors: Smirnova M. D. , Pogorelova O. A. , Fofanova T. V. , Svirida O. N. , Blankova Z. N. , Tripoten M. I. , Tamaeva B. M. , Yarovaya E. B. , Ageev F. T. , Balakhonova T. V. 
Published: July 2022

Aim. To evaluate the contribution of subclinical atherosclerosis to the stratification of patients with a SCORE risk of cardiovascular events (CVEs) <5% based on a 10-year follow-up.Material and methods. The study included 379 patients with SCORE risk of CVEs <5% (82 men, 297 women). In 2009, all patients underwent clinical examination, carotid artery (CA) ultrasound with the detection of plaques, total CA occlusion, intima-media thickness (IMT) of the common carotid artery (CCA). The plaque number was determined as the total number of all plaques in 6 following segments: both CCAs, both CCA bifurcations and both internal carotid arteries. The total stenosis was calculated as the sum of stenoses in 6 CA segments in %. In 2019, a telephone survey of patients was conducted with a questionnaire assessing the following CVEs: all-cause death, cardiovascular death, myocardial infarction (MI), stroke, myocardial revascularization, cardiovascular hospitalizations, and composite endpoint.Results. The initial patients’ age ranged from 35 to 67 years (51,1±7,5 years). Plaques from 20% to 50% were detected in 303 participants (79,94%). Over the past 10 years, there have been 5 cardiovascular deaths (1,3%), 7 MIs (1,8%), 5 cases of unstable angina (1,3%), 12 cases of myocardial revascularization (3,2%), 15 strokes (4,0%), 51 cardiovascular hospitalizations (13,5%). The proportion of patients with registered endpoints (CVE+) was 22,4% (n=85). The groups of patients with and without CVEs differed in the level of systolic blood pressure (BP) and blood triglycerides, and did not differ in the level of diastolic BP, lipid profile, glucose, heart rate, smoking status, sex, and age. In the CVE+ group, there were higher values of CCA IMT (0,65 (0,64; 0,70) mm vs 0,62 (0,62; 0,66) mm, p<0,05), total CA stenosis (102,5 (88,1; 120,8)% vs 80 (72,5; 88,1)%, p=0,01), and the CA plaque amount (4,0 (2,8; 3,9) vs 3,0 (2,6; 3,1), p=0,01), respectively. Total CA stenosis was an independent predictor of CVEs when adjusted for sex, age, systolic and diastolic BP (β=0,149; p<0,05), but not for lipid profile. A ROC-analysis revealed a cut-off point for total CA stenosis of 82,5% (AUC=0,598, 95% confidence interval 0,5243-0,673, p<0,05).Conclusion. The total CA stenosis has shown itself to be an independent predictor of CVEs in patients with a SCORE risk <5%.
New SARS-CoV-2 Omicron variant — clinical picture, treatment, prevention (literature review)
Authors: Vechorko V. I. , Averkov O. V. , Zimin A. A. 
Published: July 2022

Despite the decrease in the incidence rate, today the problem of a coronavirus disease 2019 (COVID-19) remains relevant on a global scale. Among the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) variants, the Omicron is currently dominant. The differentiating properties of the Omicron variant are a shorter incubation period (1-5 days), high contagiousness, and a relatively mild course of the disease, which is associated with the highest number of genome mutations among all SARS-CoV-2 variants. The new variant is characterized by upper respiratory tract symptoms: rhinorrhea, severe sore throat, sneezing, less commonly cough, headache, and weakness. Oral antiviral drugs Paxlovid and Molnupiravir are effective for treating mild to moderate COVID-19, including in outpatients. While corticosteroids and interleukin-6 receptor antagonists are still effective in treating patients with moderate to severe COVID-19, the effectiveness of anti-SARS-CoV-2 monoclonal antibodies has not yet been fully proven. Vaccination, especially booster doses, against SARS-CoV-2 is the most effective method of preventing COVID-19. The review purpose was to analyze the literature to determine the key aspects of prevention, clinical picture and treatment of a new SARSCoV-2 Omicron variant. The work used publications for the period from November 2021 to February 25, 2022, dedicated to the prevention, diagnosis and treatment of COVID-19 caused by the Omicron variant from the following databases: PubMed, eLibrary, MedRxiv, Google Scholar. The following key words were used: “Omicron”, “SARS CoV-2”, “COVID-19”, “Omicron treatment”. The analysis showed that COVID-19 caused by the Omicron variant is characterized by a relatively mild course. However, due to high contagiousness, this variant poses a significant problem due to the excessive load on outpatient and inpatient healthcare, including intensive care units.
Advantages of long-term combination pharmacotherapy with a beta-blocker and eplerenone in patients with ST-segment elevation acute coronary syndrome
Authors: Osipova O. A. , Mikhin V. P. , Golovin A. I. , Belousova O. N. , Perutsky D. N. , Alferov P. K. , Konstantinov S. L. 
Published: July 2022

Aim.To conduct a comparative analysis of the effect of long-term pharmacotherapy (12 months) using a β-blocker (nebivolol) and its combination with eplerenone in patients after ST-segment elevation acute coronary syndrome (STE-ACS) with heart failure with mildly reduced ejection fraction (EF) (HFmrEF) on the structural and functional cardiac parameters.Material and methods. We examined 130 patients with STE-ACS and HFmrEF after successful myocardial revascularization by percutaneous coronary intervention. The mean age of patients was 53,6 [46;57] years. Ten patients withdrew from the study due to personal reasons. Subsequently, patients were randomly divided into 2 treatment groups as follows: 60 patients received nebivolol; 60 patients received nebivolol and eplerenone. Patients were examined at two stages: 1st day of the disease before PCI and 12 months later. All patients underwent a clinical examination, echocardiography, followed by assessment of left ventricular (LV) EF, LV end-diastolic volume index (EDVI), LV endsystolic volume index (ESVI), LV myocardial index (LVMI), LV wall motion score index (WMSI), the ratio of peak early diastolic flow over peak late diastolic flow (E/A), the ratio of early diastolic transmitral flow velocity to the mitral annular velocity (E/e´).Results.Twelve-month pharmacotherapy with nebivolol in patients after STE-ACS showed an increase in LVEF by 7,2% (p<0,05), a decrease in WMSI by 13,0% (p<0,05), an increase in the E/A ratio by 11,1% (р<0,05), decrease in the E/e’ ratio by 7,2% (р<0,05). LV EDVI increased by 4,6% (p>0,05). Twelve-month combined pharmacotherapy with nebivolol and eplerenone showed an increase in LVEF by 16,0% (p<0,01), a decrease in LV ESVI by 17,9% (p<0,05), and a decrease in WMSI by 26,7% (p<0,01), LVMI — by 23,8% (р<0,01). At the same time, LV EDVI decreased by 0,7% (p>0,05). The E/A ratio increased significantly by 22,2% (<0,01), E/e’ decreased by 29,6% (р<0,01). Comparative analysis also found that combination therapy had a more pronounced positive effect on LVEF (p<0,05), ESVI (p<0,05), WMSI (p<0,05), LVMI (p<0,01), as well as diastolic function in the form of a significant increase in E/A (p<0,05) and E/e’ (p<0,01), which recovered to normal values.Conclusion.The advantages of long-term combination pharmacotherapy of nebivolol and eplerenone in HFmrEF patients after STE-ACS on both structural and functional cardiac parameters were established.
Association of humoral immunity status and thrombodynamics after vaccination with Gam-COVID-Vac and CoviVac
Authors: Drapkina O. M. , Berns S. A. , Gorshkov A. Yu. , Ryzhakova L. N. , Ivanova A. A. , Emelyanov A. V. , Voinova S. N. , Karateev R. A. , Arablinskiy N. A. , Rodionova A. A. , Bashnyak V. S. , Pokrovskaya M. S. 
Published: July 2022

The ongoing pandemic of coronavirus disease 2019 makes it important to study the immunogenicity, the duration of immune response, and the safety of existing vaccines.Aim. As part of a prospective observational study, to assess associations between levels of anti-Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) S protein IgG antibodies and thrombodynamics parameters in individuals vaccinated with Gam-COVID-Vac and CoviVac vaccines.Material and methods. The study included 137 people who completed the first 3 visits: 30 people received the Gam-COVID-Vac, 107 people — CoviVac. The study participants underwent venous blood sampling before the introduction of the 1st and 2nd vaccine doses, as well as 42 days after the administration of 1st dose in order to quantify the level of IgG antibodies. At each visit, plasma hemostasis parameters were analyzed using a thrombodynamics test.Results. During the follow-up period, there was a clear increase in the level of anti-SARS-CoV-2 S protein IgG antibodies in both groups. At the same time, this increase over time was significantly greater in Gam-COVID-Vac group. There was no correlation detected between thrombodynamics test results and the levels of anti-SARS-CoV-2 S protein IgG antibodies.Conclusion. The data obtained demonstrate the ability of both vaccines to stimulate the production of anti-SARS-CoV-2 antibodies. However, immune response to Gam-COVID-Vac is much higher. The lack of correlation between thrombodynamics and the level of specific antibodies suggests that vaccination for COVID-19 with Gam-COVIDVac and CoviVac does not cause changes in plasma hemostasis and does not increase the risk of thrombosis.
Russian-language publication activity of medical researchers in during the COVID-19 pandemic: “post-COVID-19 syndrome”
Authors: Kim O. T. , Drapkina O. M. , Rodionova Yu. V. 
Published: July 2022

Aim. To study the dynamics and pattern of publications in Russian on post-COVID-19 syndrome (PCS) in order to assess the completeness of information and identify medical specialties with its most active investigation in Russia.Material and methods. The search for publications was carried out in the database of the largest digital scientific library in Russia Elibrary.ru from February 1, 2021 to February 1, 2022. The study included publicly available medical publications on the consequences of coronavirus disease 2019 (COVID-19) in Russian. Publications were classified according to subject matter, study design, and evidence hierarchy. The data obtained is reflected using integers, percentages and graphs.Results. The study included 478 publications, of which 196 (41%) presented data from original studies, while 269 (56,3%) reflected the results of existing sources. Expert community documents accounted for 2,7%. In terms of study design, most of original studies described case series (37,2%) and individual case reports (22,4%). Casecontrol studies accounted for 20,4%, cross-sectional studies — 8,7%, prospective cohort studies — 3,6%, randomized clinical trials — 1,5%, and systematic reviews — 1%. In addition, 5,1% of publications were devoted to preclinical studies, mathematical models and various methodological aspects. By topic, the largest number of publications noted cardiovascular (12,2%) and neurological manifestations of PCS (12,2%). Furthermore, 23,5% of publications described the course of PCS in specific groups of patients, particular issues of COVID-19 consequences, and healthcare management problems. We also revealed that 11,7% of publications were devoted to general rehabilitation, 71% — to imaging diagnostics, 5,6% — to herd immunity to the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARSCoV-2), and 5,6% — to PCS features in children. The smallest number of publications considered mental (5,1%), gastroenterological (4,6%), pharmacological (4,6%), rheumatological (4%) and pulmonological aspects of PCS.Conclusion. The dynamics and pattern of publications on COVID-19 in Russian are generally consistent with global trends and reflect the natural consequences of the pandemic. This analysis of publications on PCS showed that the most in-demand specializations in this filed are cardiology, neurology, and rehabilitation.
Social Prestige of a Scientific and Pedagogical Specialists in Russia and Europe: Paradoxes of Subjective Perception of the Profession
Authors: Efimova Galina , Gribovskiy Mikhail , Sorokin Alexander 
Published: July 2022

The article presents an assessment of the level of social prestige of the academic profession in Russia and European countries. In literature a thesis about the crisis of academic profession in prevail. The empirical part of the study is based on the results of in-depth interviews with academic staff in Europe (45 informants, 2016–2019) and Russia (120 informants, 2019–2021). Informants from European universities note the high prestige of the profession, but aslo point out its decrease from the end of the 20th to the beginning of the 21st century. One of the reasons is the ignorance of society about the professional activities of scientific and pedagogical workers and their official duties, which are much broader than the transfer of knowledge to students. In addition, socio-economic factors, insufficient funding for higher education, multitasking and multidisciplinary functions of academic workers, consumer attitude of students to the educational process were named as reasons for the decline in prestige. In opposite to foreign colleagues, Russian informants has noted the increase in the prestige of the profession in recent years. At the same time, this trend does not apply to all scientific and pedagogical staff, but only to those who meet high qualification requirements. Informants from Russian universities note a positive and respectful perception of the academic profession, both by the general public and by the social environment.
Faculty position for full and visiting professor
Authors: Cruz Isabel Cristina Fonseca da 
Published: July 2022

The School of Nursing is seeking candidates for Full Professor in Nursing Administration and Visiting Professor with expertise to complement the majors of the Nursing Practitioner Master Program which are administrative, community, and adult health (gender and ethnicity focus). Candidate should also have a teaching experience and a history of funding an research agenda.Candidates for Full Professor Position contact the University website: www.uff.br
Strategic plan 2002-2003
Authors: Cruz Isabel Cristina Fonseca da 
Published: July 2022

Although the OBJN has not complete an year of existence, it is part of the process of nursing research. The OBJN vision is to make each nurse a consumer of nursing journals so we can have, in Brazil, 90.000 lectors, soon.To realize the OBJN vision and mission, a plan of goals, strategies, rand monitoring has been set forth for the first year from April 2002 through April 2003.Our goals were and still are: * Expande the OBJN subscription and authors colaboration in Brazil and abroad as well as the Editorial Board. The strategies were the utilization of mechanisms (members of editorial Board, eletronic newsletter, editor´s forum) available for snaring work of OBJN across nursing schools, hospitals, communities, etc; and the communication of interest in receive articles and abstracts in letters to organizations, members of editorial board, and subscribers. Our Editorial Board has 41 members from Brazil, North, Central and South America, and Europe. In 2002, the OBJN received 18 articles and 4 abstracts. After a three peer-review blind analyses, 16 articles and 3 were published. *Include OBNJ into nursing references databases. The strategies were the dissemination of the OBJN, the publication of research articles in the journal and the exploration of potential indexation on nursing references databases (CINAHL, LILACS, etc.); and the inclusion of ONBJ internet data bases by establishing linkages with relevant groups (NurseLinx, Nurse Editor, etc) and organizations (BIREME). *Colaborate with other nursing journals, and organizations nurses involved in research and knowledge managent in dissemination of nursing knowledge, in sepecial the Brazilian nursing knowledge nationally and internationally. The strategies were the OBJN presence on Nursing Journals Editors´Forum and the OBJN link with specialty organization (NEPAE, NESEN, Nurse Linx, UNIFESP, BIREME, etc). I am hopeful that what was obtained in 2002 will be consolidate and more will be get in 2003. The Strategic Plan 2002-2003 will enable OBJN to continue its mission which is to share nursing knowledge for the empowerment of the Brazilian nursing profession. It will permit also to expand the OBJN vision to have 1 nurse publishing in scientific journals for each 10 nurses. Soon! By the way: the OBJN would like to thanks the nursing authors that colaborate with our journal. We are also very grateful to our subscribers and to our Editoral Board. We wish you a very happy 2003.In 2202, the OBJN began with the blesses of Ogum and closes the year under the protection of Oxum. Eri ye ye ô!Oxum - painted by Carybé. Goddess of sensuality, intuition and fertility.
Paradigm shift in the development of nursing information systems
Authors: Santos Sérgio Ribeiro dos , Nóbrega Maria Miriam Lima da , Rodrigues Filho José 
Published: July 2022

The purpose of this work is to describe the emergence of alternative paradigms in information systems development and research showing that the crisis of the dominant paradigm has had an influence in the development of nursing information systems. An attempt has been made to focus on the dominant paradigm (positivism/functionalism) and on the alternative paradigms of inquiry in information systems. The analysis points out a paradigmatic crisis in nursing with the appearance of a new consciousness of the meaning of a paradigm which stress the practice in systems development. This new paradigmatic perspective try to define a new worldview with implications in nursing practice which claims a change of perspective in the social actors involved.
From uncertainity to accuracy: reflexions about nursing care under the perspective of heidegger´s theory
Authors: Simões Sonia Mara Farias 
Published: July 2022

Introduction: The descriptive research had os objetives to describe the cientific thought influence in breaking up of the health care and to consider the holistic care in nursing under Heidegger conception. Development: Men always have as characteristic to ask about the origin of the universe. They search to explain these questions through the mythological thought and subsequently through the cientific and technological throught. So, in the fifteen century came the science that was imposing your certainty, evidence and universality in the world. It benefited the generalization and the breaking up of the health care. Actually, new concepts of science and of the world have appeared because the last ones didn’t comprehend the human phenomena complexity. As the recently tendency of nursing is to reconsider men on a holistic way, I believe that the care and the cure under Heidegger conception promote a differentiated professional atitude. That characterized on helping the client to be trasparent for yourself and free for the your being and its possibilities. Conclusion: Getting back health care as a holistic experience, while nursing professionals can contribuite for population quality of life, for the practice of citizenships, and can be present in the society.