bluuebunny/crossref_metadata_2025_split huggingface dataset:
PBX1 Participates in Estrogen-mediated Bladder Cancer Progression and
Chemo-resistance Affecting Estrogen Receptors
Authors: Wan Yinxu , Zhao Yang , Che Jizhong , Tian Aimin , Zhang Gang , Xu Yankai , Li Shuhang , Liu Songlin 
Published: April 2022

Background:
Bladder cancer (BCa) is a common cancer associated with high morbidity and
mortality worldwide. Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to be involved
in tumor progression.

Objective:
The aim of the study was to explore the specific role of PBX1 in BCa and its underlying
mechanisms.

Methods:
The relative expressions of PBX1 in muscle-invasive BCa tissues and cell lines were analyzed
through RT-qPCR and western blotting. Kaplan–Meier analysis was used to analyze the relationship
between PBX1 levels and survival status. Co-immunoprecipitation (CO-IP) and chromatin immunoprecipitation
(ChIP)-qPCR assays were adopted to verify the interaction between PBX1 and Estrogen
receptors (ERs) and explore the estrogen receptors (ERs)-dependent genes transcription.

Results:
PBX1 was upregulated in invasive BCa patients and BCa cells, positively associated with tumor
size, lymph node metastasis, distant metastasis and poorer survival status. The overexpression of
PBX1 promoted cell growth, invasion, epithelial-mesenchymal transition (EMT) process and cisplatin
resistance in BCa cells, while the silence of PBX1 showed opposite effects. Furthermore, PBX1 interacted
with ERs and was required for ER function. PBX1 overexpression aggravated the tumorpromoting
effect of estrogen on BCa cells, while it partially suppressed the inhibitory effects of ER
antagonist AZD9496 on BCa cells.

Conclusion:
This study revealed that PBX1 participated in estrogen mediated BCa progression and
chemo-resistance through binding and activating estrogen receptors. Hence, PBX1 may serve as a potential
prognostic and therapeutic target for BCa treatment.
Management of Cardiac Patients in Epidemic Outbreak
Authors: Nola Iskra Alexandra , Francula-Zaninovic Sonja 
Published: April 2022

Abstract:
In times of COVID-19 epidemic/pandemic, cardiac patients are vulnerable group with
many specific conditions that could aggravate their condition. In this narrative review, we present
possible measures adequate in managing cardiac patients in epidemic outbreak. An overview of the
role of cardiologists and Crisis Management Team in management of cardiac patients is given.
Protocols and measures implemented in COVID-19 crises are presented in light of risk assessment
and disease prevention of cardiac patients and measures that should be taken for each cardiac condition.
Specificity of epidemics calls for specific measures in addressing cardiac patients as part of
the affected population. Many possible outcomes could be expected in an epidemic outbreak in relation
to cardiovascular diseases, but tailored measures will keep cardiac patients safe. Proposed
preventive measures for cardiac patients could be implemented in existing protocols for epidemic
outbreak.
The Role of Plant-based Products in the Prevention of Neurological Complications
Authors: Vellapandian Chitra , S Ankul Singh 
Published: April 2022

Background:
Neurological complications are most likely to be fatal and cause loss of
ability to function or care for self. These include Alzheimer’s disease and cognitive impairment.
The main aim of the review is to determine the effects of various drugs and their cognitive risk
with the need to opt for herbal therapy as an adjuvant in treating neurological conditions like Alzheimer’s
disease with lesser-known side effects.

Methods:
Involved a detailed literature survey which was performed through an online database,
such as Science Direct, Google Scholar, Scopus, Cochrane, and PubMed. The study included randomized
trials and original research conducted by herbal supplements on animal models to assess
the expression of upregulation of signalling pathways. Various studies involved in treating dementia,
neurological disorders, Alzheimer disease, and cognitive dysfunction were included.

Results:
found that various studies involved plant-based products were showing improvement in
prevention of disease and signalling pathways with lesser-known side effects.

Conclusion:
it was observed that plant-based products play a major role in the prevention of neurological
complications. Herbal medicines could most suitably prevent Alzheimer’s risk with less
known side effects in contrast with the existing treatment patterns. However, to improve the utility
of herbal medicines, more evidences from in vitro, in vivo, and clinical trials need to be addressed.
MicroRNA-7 Regulates Insulin Signaling Pathway by Targeting IRS1,
IRS2, and RAF1 Genes in Gestational Diabetes Mellitus
Authors: Bhushan Ravi , Rani Anjali , Gupta Deepali , Ali Akhtar , Dubey Pawan K. 
Published: April 2022

Background:
Small non-coding micro RNAs (miRNAs) are indicated in various metabolic processes and play a critical role in disease pathology, including gestational diabetes mellitus (GDM).

Objective:
The purpose of this study was to examine the altered expression of miRNAs and their target genes in placental tissue (PL), cord blood (CB), and maternal blood (MB) of matched non-glucose toler-ant (NGT) and GDM mother.

Methods:
In a case-control study, micro-RNA was quantified from forty-five serum (MB n = 15, CB n = 15, and PL n = 15) and matched placental tissue using stem-loop RT-qPCR followed by target prediction, network construction and functional and pathways enrichment analysis. Further, target genes were veri-fied in-vitro through transfection and RT-qPCR.

Results:
Five miRNAs, namely hsa-let 7a-5P, hsa-miR7-5P, hsa-miR9-5P, hsa-miR18a-5P, and hsa-miR23a-3P were significantly over-expressed (p < 0.05) in all three samples namely PL, CB, and MB of GDM patients. However, the sample-wise comparison reveals higher expression of miRNA 7 in MB while lowest in CB than control. Furthermore, a comparison of fold change expression of target genes discloses a lower expression of IRS1, IRS2, and RAF1 in MB while comparatively higher expression of NRAS in MB and CB. In-vitro validation reveals lower expression of IRS1/2 and RAF1 in response to overexpression of miR-7 and vice-versa. Thus it is evident that increased miRNA7 expression causes down-regulation of its target genes IRS1, IRS2, and RAF1 in GDM mother compared to control. Further, target prediction, pathway enrichment, and hormone analysis (significantly higher FSH & LH in MB of GDM compared to NGT) revealed insulin signaling, inflammatory and GnRH signaling as major path-ways regulated by miRNA7.

Conclusions:
Thus, an elevated level of miRNA7 may be associated with the progression of GDM by al-tering the multiple pathways like insulin, GnRH, and inflammatory signaling pathways via targeting IRS1, IRS2, and RAF1, implicating a new therapeutic target for GDM.
Feasibility, Acceptability, and Preliminary Outcomes of a Cognitive Behavioral Therapy–Based Mobile Mental Well-being Program (Noom Mood): Single-Arm Prospective Cohort Study
Authors: McCallum Meaghan , Ho Annabell Suh , Mitchell Ellen Siobhan , May Christine N , Behr Heather , Ritschel Lorie , Mochrie Kirk , Michaelides Andreas 
Published: April 2022

Background
The prevalence of anxiety, depression, and general distress has risen in recent years. Mobile mental health programs have been found to provide support to nonclinical populations and may overcome some of the barriers associated with traditional in-person treatment; however, researchers have voiced concerns that many publicly available mobile mental health programs lack evidence-based theoretical foundations, peer-reviewed research, and sufficient engagement from the public.

Objective
This study aimed to evaluate the feasibility, acceptability, and preliminary outcomes of Noom Mood, a commercial mobile cognitive behavioral therapy– and mindfulness-based program.

Methods
In this single-arm prospective cohort study, individuals who joined Noom Mood between August and October 2021 completed surveys at baseline and 4-week follow-up. Per-protocol analyses included those who completed both surveys (n=113), and intention-to-treat analyses included all participants (N=185).

Results
A majority of the sample reported that the program is easy to use, they felt confident recommending the program to a friend, and they perceived the program to be effective at improving stress and anxiety. There were significant improvements in anxiety symptoms, perceived stress, depressive feelings, emotion regulation, and optimism in both the per-protocol and intention-to-treat analyses (all P<.001). Participants reported benefiting most from learning skills (eg, breathing and cognitive reframing techniques), interacting with the program features, and gaining awareness of their emotions and thought patterns. Participants also made a number of suggestions to improve product functionality and usability.

Conclusions
Results suggest that Noom Mood is feasible and acceptable to participants, with promising preliminary outcomes. Future studies should build on these results to evaluate the effects of Noom Mood using more rigorous designs.
Home Delivery of Water for Caries Prevention in Latinx Children (“Sediento por una Sonrisa,” Thirsty for a Smile): Protocol for a Single-Arm Feasibility Study
Authors: Cunha-Cruz Joana , Ko Linda K , Mancl Lloyd , Rothen Marilynn L , Harter Catherine , Davis Stephen , Koday Mark 
Published: April 2022

Background
Dental caries has significant public health implications afflicting young children. In addition to low social economic status, the most prominent risk factor for early childhood caries is sugar in the diet, particularly sugar-sweetened beverages. Dental treatment for caries in young children is commonly performed under general anesthesia and a significant proportion of children require repeated treatment. Interventions to reduce sugar-sweetened beverage consumption could lead to reduced rates of retreatment for dental caries in young children.

Objective
This protocol describes the rationale, design, and methods of the “Thirsty for a Smile” feasibility study. The aim of the study is to assess the feasibility, acceptability, and appropriateness of a dietary intervention promoting water consumption in lieu of sugar-sweetened beverages among young patients, mostly from Latino heritage.

Methods
This protocol describes a single-arm feasibility study. Twenty-one dyads of children and their caregivers will be recruited. Children between 2 and 9 years old who recently had treatment under general anesthesia for early childhood dental caries will be eligible to participate. The intervention has two components: (1) environmental, in which bottled water is delivered to participants’ homes; and (2) behavioral, in which caregivers will receive patient-centered counseling to increase children’s water intake and reduce sugar-sweetened beverages consumption. Dental caries and anthropometric data will be collected at examination during baseline and final visits. The primary outcome is feasibility and secondary outcomes are acceptability and appropriateness of the intervention.

Results
Funding has been obtained from the National Institute of Dental and Craniofacial Research and the University of Washington approved the study. The feasibility study was conducted from March to November 2019.

Conclusions
This feasibility study will test the study processes prior to a two-arm randomized controlled trial to determine feasibility and acceptability of the intervention and study procedures. This study may provide useful information for other researchers attempting to test similar interventions.

International Registered Report Identifier (IRRID)
RR1-10.2196/37200
PSYCHOLOGICAL RESOURCES OF PERSONAL READINESS FOR STUDENTS’ ACTIVITIES IN A SITUATION OF CHANGE
Authors: Буравлева Наталья Анатольевна , Каракулова Ольга Викторовна , Атаманова Инна Викторовна , Богомаз Сергей Александрович 
Published: April 2022

Современная ситуация характеризуется изменениями в различных сферах жизни человека, приводит к существенной перестройке его активности, деятельности, состояния. В условиях транзитивности, растущей неопределенности становится актуальным определение психологических ресурсов личностной готовности к деятельности молодежи. В исследовании приняли участие студенты университетов г. Томска (N = 263). В нем был использован регрессионный и кластерный анализ. Результаты исследования показали, что в качестве психологических ресурсов личностной готовности к деятельности обучающихся следует рассматривать эмоциональный интеллект, мотивацию, ценности сохранения и открытости, целеполагание и рефлексию. Результаты анализа имеют теоретическую и практическую значимость. Они актуализируют вопрос рассмотрения компетенций будущих специалистов, которым предстоит работать в новых условиях, обращают внимание на то, что образовательный процесс должен быть ориентирован не только на приобретение фундаментальных знаний и профессиональных умений студентами, но и на развитие их личности.
The current situation is characterized by changes in various spheres of human life, leading to a significant restructuring of his activities, condition. People react differently to changes. They plunge some into a state of stress, confusion about the future, while others are mobilized, put in front of the need for change. The different position and behavior of a person in a situation of change are largely determined by the resources that a person possesses. In this situation, the problem of studying the self-regulation of the individual, his active life position in the changing conditions of study, work and everyday life becomes relevant. The subject of discussion is increasingly the question of what can serve as psychological resources for a person in a situation of transitivity. This question is especially relevant in relation to students, their personal readiness for activity. Students of Tomsk universities took part in the presented study (N=263). It used regression and cluster analysis. The results of the study showed that emotional intelligence, motivation, values of preservation, values of openness, goal-setting and reflection should be considered as psychological resources of personal readiness for students’ activities. The results of the study have theoretical and practical significance. They actualize the issue of taking into account the competencies of future specialists who will have to work in new conditions. The results of the study indicate that the professional training of specialists should include not only the acquisition of fundamental knowledge and professional skills, but also the development of personality in the educational process.
eHealth challenges in rehabilitation processes - rehabilitation professionals’ experiences in the North Savo region
Authors: Äijö Marja , Reijula Jori , Komulainen Pirjo 
Published: April 2022

Aging people are forced to steadily extend their working-lives since the old-age dependency ratio will rise considerably in the near future. Meanwhile, social and healthcare resources will become increasingly scarce, although the need for healthcare and rehabilitation services is bound to increase. The aim of this study was to examine rehabilitation professionals’ experiences related to eHealth and technology in the rehabilitation process in the North Savo region. The research was carried out as a part of the European Social Fund (ESF) funded project ”Expertise and Business Network for Rehabilitation Services in Northern Savo”.
30 rehabilitation workers were interviewed (67% women) in 2020. The participants were aged 24-60 years and their job titles were e.g. doctors, physiotherapists, practical nurses and community sector representatives. The interviews were carried out using a semi-structured format. The interviews were recorded, transcribed, and analysed using the inductive content analysis method.
The technology and digitalisation experiences of the rehabilitation workers in North Savo region can be divided into five categories. Technical problems causing challenges in rehabilitation included inadequate information and patient data management, and poor or lacking data-applications, ICT-tools and systems. The cost of technology was perceived as a factor influencing rehabilitation from both an individual and organisational perspective. The emergence of COVID-19 has had a positive impact on the use of technology and digital services. Suitable technology and digital services for rehabilitation need to be developed towards a more individual, client-centric direction. To promote the adoption of technology in the field of rehabilitation and to support positive change in attitudes towards technology, more education is needed.
The ever-evolving field of rehabilitation demands effective eHealth applications and processes alongside highly competent rehabilitation professionals to meet the needs of the aging population base in North Savo region. There is a need for more client-centric eHealth and rehabilitation processes, wherein the rehabilitation workers’ needs are met – physically and psychosocially. By bringing together rehabilitation and ICT expertise in North Savo region, it is possible to provide training and education to raise the level of both the rehabilitation processes and level of expertise of rehabilitation workers in the region.
L’AMOUR ENTÉNÈBRE
Authors: SARFATI Jean-Jacques 
Published: April 2022

The Darkness of Love. This text defends the idea of the philosophical evil as opposed to purely psychological and/or sociological evil. Philosophical evil is an evil that forces action and reflection in all matters. Love, in the contemporary world, is a victim of this evil and it has been plunged into darkness by mediatizing approaches that drive us to despair. The objective here is to give substance to the concept of love by enlightening it again and taking it out of the vision that is either too relativist or too absolutist in which it has been confined.
RESUMÉE : Dans ce texte, est défendue l’idée du mal philosophique qui s’oppose au mal purement psychologique et/ou seulement sociologique. Le mal philosophique est un mal qui oblige à une action et une réflexion dans tous les sujets. L’amour, dans le monde contemporain est victime de ce mal et il a été plongé dans les ténèbres par des approches médiatisantes qui nous désespèrent. L’objectif est ici de lui redonner substance en l’éclairant à nouveau et en le sortant de la vision soit trop relativiste soit trop absolutiste dans laquelle il a été enfermé.
Mots-clés : amour ; mal ; sujet ; Nietzsche
Fast fourier transform based new pooling layer for deep learning
Authors: Hamad Aqeel Mohsin 
Published: April 2022

Abstract
Convolution is considered most significant layer in deep learning because it can extract best features of data through the network but it may result in huge volume of data. This problem can be solved by using pooling. In this paper, A novel pooling method is proposed by using discrete Fourier transform (DFT), this method is used DFT technique to transform the data from spatial domain into frequency domain to preserve the most important information from the details coefficients, where the details information of the image is less significant, therefore it can be discarded to down sample the size of dimensions. Its effect will be great with advantage of reducing the eliminated details information as compared with other standard methods. After applying DFT, the most significant coefficients, which represent most important features are cropped while less important details will be discarded then the data are reconstructed by applying inverse DF, therefore the high quality of features are extracted, which solve the problem of losing significant information during the pooling layer. Different methods are proposed based on the scenario of using DFT. The proposed methods are tested by extracting pooled image then the original images were retrieved using only the pooled images. Then the retrieved images are compared with original images by using different measures such as SNR, correlation and SSIM. Then the proposed layers used for image classification for two different datasets. The results proved that the proposed methods outperformed standard methods, thus it can be used for deep learning application.
Early postoperative sacral fracture after short-segment posterior lumbar interbody fusion for L5/S1 isthmic spondylolisthesis: A case report
Authors: Kawasaki Toshinari , Takayama Motohiro , Maki Yoshinori , Kobayashi Tamaki , Ioroi Yoshihiko 
Published: April 2022

Background:
Early postoperative sacral fractures are extremely rare complications of single-level posterior lumbar interbody fusions (PLIFs).

Case Description:
A 71-year-old female presented with lower back pain and right S1 radiculopathy attributed to MR-documented L5/S1 isthmic spondylolisthesis. Following a L5 laminectomy and bilateral L5/S1 PLIF, she experienced sacral pain while sitting. When the MR showed a sacral insufficiency fracture with anterolisthesis at L5/S1, a secondary posterior fusion was extended to the pelvis, utilizing bilateral iliac screws. Following this reoperation, the patient did well and went on to achieve arthrodesis.

Conclusion:
Early postoperative sacral fractures that occur following single-segment L5/S1 PLIF for isthmic spondylolisthesis warrant fusion to the pelvis with bilateral iliac screws.
Knowledge, attitudes, and behaviors regarding the use of clinical practice guidelines among spine surgeons in Latin America
Authors: Rech Matheus Machado , Bicca Yan De Assunção , Ramos Miguel Bertelli , Gionedis Murillo Cesar , Aguzzoli Arthur , Falavigna Asdrubal 
Published: April 2022

Background:
Clinical Practice Guidelines (CPGs) are invaluable tools to assure evidence-based spine surgery care. In this study, we aimed to identify perceptions, barriers, and potential determinants for the use of CPG among Latin American spine surgeons.

Methods:
A 28-item questionnaire regarding the use of CPGs was sent to the members of AO Spine Latin America. The questionnaire was subdivided into three sections: (1) demographic data; (2) perceptions and awareness of CPGs; (3) and potential barriers to CPG use. Multivariate logistic regression was performed to assess potential associations with CPG use.

Results:
A total of 304 spine surgeons answered the questionnaire. Most of the participants were male (91.8%) and orthopedic spine surgeons (52.3%) who averaged 45–65 years of age. Most respondents were aware of some CPGs for spine care (68.8%) and reported using them (70.4%); lack of awareness about CPGs was the most frequent barrier to their use (65.1%).

Conclusion:
Awareness of CPGs in spine surgery is of paramount importance for their use. Educational programs explaining the importance and benefits of spine care CPG surgical and clinical practice would increase the adherence of physicians to the guidelines.
Hemorrhagic cavum vergae colloid cyst: A presentation of anterograde amnesia without hydrocephalus
Authors: Snyder Rita , Lee Sungho , Heck Kent , Mandel Jacob J. , Patel Akash J. , Jalali Ali 
Published: April 2022

Background:
Colloid cysts characteristically arise from the roof of the third ventricle near the foramen of Monro, causing symptoms from obstructive hydrocephalus. However, atypical locations have been reported with various clinical presentations, growth patterns, and displacement of surrounding anatomic structures.

Case Description:
Here, we describe the interesting case of a patient with a large hemorrhagic cavum vergae colloid cyst presenting with anterograde amnesia soon after starting antiplatelet therapy. The patient did not have hydrocephalus on presentation and his amnesia persisted after complete removal of the hemorrhagic mass through transcallosal interforniceal approach.

Conclusion:
To the best of our knowledge, this is the only reported instance of a colloid cyst presenting with amnesia in the absence of hydrocephalus. Pathophysiology as well as diagnostic and management strategies of hemorrhagic colloid cysts are discussed.