bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of uniform capacitively coupled electric fields on matrix metabolism of osteoarthritic cartilage
Authors: Noruzi Kaleb , Swami Pooja , Frejo Lidia , Wright Jason , Wong Jason , Grande Daniel , Datta-Chaudhuri Timir 
Published: September 2022

Abstract
Background
Osteoarthritis (OA) is a common and debilitating condition characterized by degeneration of hyaline cartilage. Currently, there is no treatment for OA that directly targets degradation of cartilage matrix. Capacitively coupled electric fields (CCEFs) represent a noninvasive and cost-effective treatment modality that can potentially restore articular cartilage homeostasis. Previous studies showed that stimulation of articular cartilage with CCEFs resulted in upregulation of anabolic factors and downregulation of catabolic factors. These studies didn’t explain the derivation of the CCEFs or verify their uniformity and field strength, so it’s possible that cartilage wasn’t exposed to uniform field strength. The present study aims to employ CCEFs with verified uniform field strength in two in-vitro models of OA to investigate its potential to preserve cartilage matrix and validate the results of the aforementioned studies.

Methods
Rabbit hyaline chondrocytes and full-thickness bovine articular cartilage explants were cultured in the absence or presence of CCEF and in the absence or presence of Interleukin1-B (IL-1B). Quantitative polymerase chain reaction (QPCR) was performed on chondrocytes to measure gene expression of ADAM-TS4, MMP3, MMP9, IL-6, TIMP1, and TIMP2. QPCR was performed on explants to measure gene expression of MMP3, Aggrecan, Collagen-2, and TIMP1. Aggrecan concentration in explants was measured with histology. Statistical analysis was performed using one-way analysis of variance and Tukey–Kramer multiple comparison test.

Results
The treatment of chondrocytes with IL-1B resulted in upregulated expression of ADAM-TS4, MMP3, MMP9, and IL-6, while simultaneous administration of IL-1B and CCEF led to a relative decrease in ADAM-TS4, MMP3, MMP9, and IL-6 expression and a relative increase in TIMP1 and TIMP2 expression. Application of IL-1B and CCEF to the explants resulted in decreased expression of MMP3 and increased expression of Aggrecan, Collagen-2, and TIMP1 when compared to application of IL-1B alone.

Conclusion
The data indicate that application of a CCEF with verified uniformity may result in upregulation of cartilage anabolic factors even in the presence of IL-1B while attenuating IL-1B induced upregulation of catabolic factors in both monolayer culture and whole tissue. These results demonstrate the potential of CCEFs to suppress the progression of OA and regenerate articular cartilage matrix.
Development of a qualitative data analysis codebook informed by the i-PARIHS framework
Authors: Ritchie Mona J. , Drummond Karen L. , Smith Brandy N. , Sullivan Jennifer L. , Landes Sara J. 
Published: September 2022

Abstract
Background
The Integrated-Promoting Action on Research Implementation in Health Services (i-PARIHS) framework and its predecessor, PARIHS, have been widely utilized in implementation studies. Although i-PARIHS developers have focused on creating tools to guide facilitators in its application in practice, tools are also needed for evaluation and research. Codebooks with clear and meaningful code labels and definitions are an important component of qualitative data analysis and have been developed for other widely used frameworks. There is no such codebook for i-PARIHS. Additionally, sub-constructs for the Innovation, Recipients, and Context constructs lack definitions, and there is no sub-classification of facilitation activities for the Facilitation construct. The lack of a standardized codebook hinders our ability to synthesize research findings across studies, explore and test the range of activities that are utilized in facilitation efforts, and potentially validate and further refine i-PARIHS. This paper describes a rigorous process of developing a detailed qualitative codebook informed by the i-PARIHS framework.

Methods
A workgroup of qualitative researchers conducted a rigorous four-phase process to develop a codebook informed by i-PARIHS. In phase 1, workgroup members reviewed and discussed literature, consulted an organizational scientist, and drafted and refined subcodes and definitions for i-PARIHS constructs. In phase 2, they obtained feedback from an expert panel and further refined subcodes and definitions. In phase 3, they obtained feedback from i-PARIHS developers/experts and incorporated it into the codebook. Finally, two studies piloted the application of the codebook which informed the final version.

Results
The resulting i-PARIHS-informed codebook includes definitions for the four main constructs of the framework: Innovation, Recipients, Context, and Facilitation; subcodes and definitions for characteristics of each of these constructs; and instructions for the suggested application of individual codes and use of the codebook generally.

Conclusions
The standardized codes and definitions in the codebook can facilitate data exploration, pattern identification, and insight development informed by the i-PARIHS framework. Qualitative analysts can also use them to explore interactions between i-PARIHS constructs, maximize the potential for comparing findings across studies, and support the refinement of the i-PARIHS framework using empirical findings from multiple studies.
Angiotensin II type 1 receptor (AT1) blockade by Telmisartan attenuates hepatic steatosis in high-fat fed mice reducing Resistin, TRL4, and Myd88 expression
Authors: Borém Luciana Mendes Araújo , Freitas Daniela Fernanda , Machado Amanda Souto , Paraíso Alanna Fernandes , Caldas Bruna Viana , Neto João Felício Rodrigues , Lima Juliana Pinto , Guimarães André Luiz Sena , de Paula Alfredo Maurício Batista , Santos Sérgio Henrique Sousa 
Published: September 2022

Abstract
Background
Telmisartan is a non-peptide angiotensin II receptor antagonist which acts by ACE/AngII/AT1 axis blockade (ARB). In the last years increasing evidence of its metabolic benefits pointed out this drug as the most promising ARB for nonalcoholic fatty liver disease (NAFLD) treatment. The aim of the present study was to investigate the Telmisartan effect on treating NAFLD in mice fed with a high-fat diet evaluating liver gene modulation. Twenty-four male mice were divided into four groups and fed for 60 days with a standard diet (ST), standard diet plus TEL (ST+TEL 5 mg/kg/day by gavage for 4 weeks), high-fat diet (HFD), or high-fat diet plus TEL (HFD+TEL 5 mg/kg/day by gavage for 4 weeks). Body weight, lipid profile, insulin, alanine transaminase, and aspartate aminotransferase were evaluated. Liver histology was analyzed. US imaging was performed to access liver dimension and echogenicity and also epididymal fat pad thickness. The expression of proinflammatory resistin/TRL4/MYD88 pathway was analyzed.

Results
The main findings showed that TEL reduced the resistin, TRL4, and Myd88 liver expression in the HFD + TEL group when compared to the obese control group (HFD). Decreased hepatic steatosis in the HFD + TEL group demonstrated by US measurements of the liver longitudinal axis and echogenicity were observed. In addition, TEL reduced epididymal adipose pad thickness, body weight, transaminases, and improved glucose tolerance test and HDL cholesterol.

Conclusions
We observed that Telmisartan treatment improved metabolism, decreasing NAFLD.

Graphical Abstract
Telmisartan improves metabolic and lipid profile and liver steatosis of obese mice
Surgical Site Infection in the Intensive Care Setting After Posterior Spinal Fusion: A Case Series Highlighting the Microbial Profile, Risk Factors, and the Importance of Comorbid Disease Burden
Authors: Cloney Michael Brendan , Hopkins Benjamin , Shlobin Nathan A. , Kelsten Max , Goergen Jack , Driscoll Conor , Svet Mark , Ordon Matthew , Koski Tyler , Dahdaleh Nader S. 
Published: September 2022

BACKGROUND:
Most posterior spinal fusion (PSF) patients do not require admission to an intensive care unit (ICU), and those who do may represent an underinvestigated, high-risk subpopulation.

OBJECTIVE:
To identify the microbial profile of and risk factors for surgical site infection (SSI) in PSF patients admitted to the ICU postoperatively.

METHODS:
We examined 3965 consecutive PSF patients treated at our institution between 2000 and 2015 and collected demographic, clinical, and procedural data. Comorbid disease burden was quantified using the Charlson Comorbidity Index (CCI). We performed multivariable logistic regression to identify risk factors for SSI, readmission, and reoperation.

RESULTS:
Anemia, more levels fused, cervical surgery, and cerebrospinal fluid leak were positively associated with ICU admission, and minimally invasive surgery was negatively associated. The median time to infection was equivalent for ICU patients and non-ICU patients, and microbial culture results were similar between groups. Higher CCI and undergoing a staged procedure were associated with readmission, reoperation, and SSI. When stratified by CCI into quintiles, SSI rates show a strong linear correlation with CCI (P = .0171, R = 0.941), with a 3-fold higher odds of SSI in the highest risk group than the lowest (odds ratio = 3.15 [1.19, 8.07], P = .032).

CONCLUSION:
Procedural characteristics drive the decision to admit to the ICU postoperatively. Patients admitted to the ICU have higher rates of SSI but no difference in the timing of or microorganisms that lead to those infections. Comorbid disease burden drives SSI in this population, with a 3-fold greater odds of SSI for high-risk patients than low-risk patients.
Multidisciplinary approach for a severe head burn caused by high-voltage electrical shock - a case report
Authors: Hoffman Zofia , Homa Piotr , Gałązka Jakub Krzysztof , Sakwa Leon , Szymoniuk Michał , Domagalski Łukasz , Wdowiak Marcin , Czyżewski Wojciech , Rola Radosław , Antonov Sergey 
Published: September 2022

In modern reconstructive medicine, personalized bone substitutes provide therapeutic hope for patients with non-standard bone defects. The study aims to present a description of a case of using a personalized bone substitute material, taking into account the vascular connections formed after a previous skin transplant.
The 29-year-old patient was admitted to the plastic surgery department urgently after being electrocuted with high voltage. Due to extensive scalp burns, a skin graft was performed in the area of previously removed skin along with a charred skull bone vault.
After a few months, the patient was qualified for cranioplasty with the use of personalized bone substitutes. The necessity to make cuts around the vascular connections present in the transplanted tissue was the main difficulty in the for the operator.
The operation was successful and the recovery was uneventful. The patient was discharged home in good general and local condition.
The presented case illustrates the need to take into account creating vascular connections with the use of personalized bone substitutes in patients after skin transplants.
Kemitraan Pembangunan Desa untuk Peningkatan Efisiensi dan Efektivitas Waktu Kerja Petani dalam Mencapai Ketahanan Pangan melalui Pemanfataan TTG Transplanter Sistem Jajar Legowo pada Komunitas Petani NU Wilayah Cabang Jatirejo, Mojokerto
Authors: Rusdiyana Liza , Suhariyanto Suhariyanto , Sampurno Bambang , Sanyoto Budi Luwar , Mashuri Mashuri 
Published: September 2022

Kelompok Tani ini memiliki tanah mereka sendiri yang terbilang cukup luas per orangnya, akan tetapi keuntungan yang mereka dapatkan dari hasil Tanah (Sawah) mereka sendiri terbilang kurang begitu besar karena ongkos yang begitu besar dalam proses penanaman hingga proses pemanenan padi, dikarenakan untuk memberi upah sekitar Rp. 60.000-, per orang per ru tidak termasuk ongkos Makan dan Rokok kalaupun ada yang merokok sedangkan kapasitas kerjanya untuk satu petak sawah membutuhkan sekitar 3-4 orang dan memakan waktu sehari penuh, sedangkan dengan menggunakan Mesin yang berada dipasaran saat ini membutuhkan waktu sekitar 4 jam untuk menanam 1 hektar sawah dengan ongkos Rp. 150.000-, per ru ( 1 hektar sama dengan 700 ru ).
Ditinjau dari segi efisiensi masih terbilang sangat kurang dengan proses tradisional tersebut, sehingga para petani lebih memilih menggunakan mesin penanam padi yang modern tersebut, akan tetapi harga dari mesin mesin tersebut masih terbilang mahal untuk para petani dan harga sewa pun juga masih lumayan menguras kantong para petani. Proses penyemaian, penanaman hingga pemanenan yang sangat sederhana membutuhkan banyak tenaga kerja dan proses waktu yang lama. Hal ini terjadi karena petani masih menggunakan metode tanam konvensional. Komunitas Petani NU Wilayah Cabang Jatirejo saat ini mulai mencoba system jajar legowo. Sistem ini memudahkan petani untuk melakukan ativitas perawatan seperti pembersihan gulma (dadak), pemupukan, serta ternyata dengan system ini jumlah bibit tanam lebih sedikit namun hasil anakan juga bisa lebih banyak. Menurut para teman-teman petani NU ini, aplikasi penggunaan mesin penanm padi juga sangat dibutuhkan. Namun harga mesin baik pembelian maupun sewa sangat memberatkan petani. Selain itu system penanaman bibitnya juga masih sama dengan system tanam konvensional bukan system tanam jajar legowo. Berdasarkan permasalahan inilah, kami mencoba memberikan solusi agar dalam proses penanaman bibit padi ini tidak membutuhkan banyak tenaga, biaya dan waktu yang lama, yaitu dengan menciptakan sebuah alat bantu dengan mengaplikasikan sistem tanam jajar legowo yang dapat dioperasikan secara mudah untuk dapat dioperasikan oleh semua masyarakat petani dengan harapan dapat meningkatkan produktifitas, mempersingkat waktu tanam, hemat biaya serta dapat dikembangkan oleh para petani itu sendiri dengan harga yang cukup terjangkau.
Dietary practices and nutritional status of young children in the former ensete monoculture dominated Sidama region, southern Ethiopia: A community based cross-sectional study
Authors: Behailu Tsigereda , Mengesha Selamawit , Lindtjorn Bernt , S. Engebretsen Ingunn Marie 
Published: September 2022

Background
Child undernutrition is a challenge in Ethiopia, where morbidity and mortality among children are attributed to it. This study aimed to describe the dietary practices, household food insecurity, and nutritional status of young children in Dale district, Sidama region, southern Ethiopia. We discuss our findings in light of research from the same area 3 to 5 decades ago, and we analyze factors associated with linear growth of young children.

Method
A community-based cross-sectional study design was employed. Children less than two years old and their primary caretakers (n = 903) were included in this study. Among whom 791 children were aged above six months and 742 children out of 791 provided a 24-hour dietary recall. Interviews capturing other dietary practices, food insecurity, socio-demographic characteristics, anthropometric measurements, and haemoglobin assessments were performed for all. The WHO Child Growth Standards were used to calculate anthropometric indices and to describe stunting (length-for-age z-score <-2). Haemoglobin measures below 11g/dl were defined as low haemoglobin levels (anaemia). Multilevel linear regression was used to identify factors associated with length-for-age z-scores.

Result
The prevalence of stunting, wasting, and anaemia was 39.5%, 3.9%, and 61.7%, respectively. The majority of children (97%) ate cereals (maize) during the past 24 hours, and 79.6% of households use maize as the main food. Three fourth (75%) of the total households were food insecure ranging from mild to severe food insecurity. Boys were at higher risk of having lower length-for-age z-score than girls (β -0.53; 95% Confidence Interval (CI): -0.78, -0.27). For each month the children grew older, length-for-age z-score decreased slightly (β -0.06; -0.07, -0.04). Household food insecurity scores (β -0.05; -0.08, -0.01) and children haemoglobin levels, (β 0.21; 0.06, 0.35) were also associated with length-for-age z-score among young children.

Conclusion
Linear growth failure (stunting) was prevalent among young children in the rural Sidama region and the majority of them were also anaemic. Older age, male sex, a lower haemoglobin level in children, and household food insecurity were risk factors of linear growth failure in young children. Maize seems to be the dominant food in this previously ensete dominated area; however, there have been minimal improvements in length-for-age z-score over decades. Strategies to ensure household’s food access and improve the quality of child diets need to be implemented.
Contemporary Peruvian Cinema: History, Identity and Violence on Screen, Sarah Barrow (2018)
Authors: Jarman Rebecca 
Published: September 2022

Review of: Contemporary Peruvian Cinema: History, Identity and Violence on Screen, Sarah Barrow (2018)
London and New York: I.B. Tauris, 342 pp.,
ISBN 978-1-78453-821-7, h/bk, £69.00
Casting Masculinity in Spanish Film: Negotiating Identity in a Consumer Age, Mary T. Hartson (2017)
Authors: Fouz Hernández Santiago 
Published: September 2022

Review of: Casting Masculinity in Spanish Film: Negotiating Identity in a Consumer Age, Mary T. Hartson (2017)
New York: Lexington Books, 214 pp.,
ISBN 978-1-49853-711-7, h/bk, $95
ISBN 978-1-49853-712-4, e-book, $90
Multiplatform Media in Mexico: Growth and Change Since 2010, Paul Julian Smith (2019)
Authors: Thornton Niamh 
Published: September 2022

Review of: Multiplatform Media in Mexico: Growth and Change Since 2010, Paul Julian Smith (2019)
Cham: Palgrave Macmillan, 204 pp.,
ISBN 978-3-03017-539-9, p/bk, £20.29, e-book, £21.84
Documentary Filmmaking in Contemporary Brazil: Cinematic Archives of the Present, Gustavo Procopio Furtado (2019)
Authors: Bedran Marina 
Published: September 2022

Review of: Documentary Filmmaking in Contemporary Brazil: Cinematic Archives of the Present, Gustavo Procopio Furtado (2019)
New York: Oxford University Press, 265 pp.,
ISBN 978-0190867041, h/bk, £64.00
ISBN 978-0190867058, p/bk, £25.99
Inhabiting the In-Between: Childhood and Cinema in Spain’s Long Transition, Sarah Thomas (2019)
Authors: Marsh Steven 
Published: September 2022

Review of: Inhabiting the In-Between: Childhood and Cinema in Spain’s Long Transition, Sarah Thomas (2019)
Toronto: University of Toronto Press, 240 pp.,
ISBN 978-1-48750-488-5, h/bk, $77.00
Tinjauan Yuridis Karakteristik Penggunaan Hak Pakai dalam Kepemilikan Apartemen oleh Warga Negara Asing di Indonesia
Authors: Mahadewi Kadek Julia 
Published: September 2022

Dalam susunan hukum pertanahan nasional, hubungan hukum antara orang, baik warga Negara Indonesia (WNI) maupun warga negara asing (WNA), serta perbuatan hukumnya terkait dengan tanah telah ditentukan dalam Undang-Undang No 5 Tahun 1960 tentang Peraturan Dasar Pokok – Pokok Agraria (UUPA). Salah satu prinsip yang dipergunakan oleh UUPA adalah prinsip nasionalitas. Hanya WNI yang dapat mempunyai hubungan sepenuhnya dengan tanah sebagai bagian dari bumi dalam frasa yang termuat dalam pasal 33 ayat 3 UUD NRI 1945. Hubungan yang dimaksud adalah dalam wujud dari hak milik. Sedangkan bagi WNA dan badan hukum asing yang hanya mempunyai perwakilan di Indonesia dapat diberikan hak pakai.Adapun rumusan masalah yang diangkat dalam jurnal ini pertama, Bagaimanakah karakteristik hak pakai dalam konsep kepemilikan apartemen oleh warga negara asing di Indonesia? Kedua, Bagaimanakah konsistensi pengaturan hak pakai dalam konsep kepemilikan apartemen oleh warga negara asing di Indonesia? Adapun kesimpulan yang diperoleh pertama, karakteristik hak pakai dalam konsep kepemilikan apartemen oleh warga negara asing di Indonesia adalah suatu hak yang meliputi hak atas tanah bangunan dan tanah pertanian dan kedua Konsistensi pengaturan hak pakai dalam konsep kepemilikan apartemen oleh warga negara asing di Indonesia adalah pengaturan hak-hak atas tanah bagi orang asing dalam peraturan perundang-undangan antara lain dapat dilihat dalam Pasal 42, 45 dan 55 UUPA.
Tantangan Pelaksanaan Kegiatan Pendaftaran Tanah Sistematis Lengkap dalam Rangka Mewujudkan Pemberian Kepastian Hukum
Authors: Ardani Mira Novana 
Published: September 2022

Perwujudan pendaftaran tanah di seluruh wilayah Indonesia telah didukung dengan dikeluarkannya aturan-aturan yang mengatur mengenai pendaftaran tanah, dan dalam rangka percepatan pendaftarannya dilakukan secara sistematis, namun tetap dimungkinkan adanya hambatan, kendala yang ini dapat merupakan suatu tantangan tersendiri untuk mewujudkan amanah yang terdapat dalam Pasal 19 ayat (1) UUPA. Permasalahan yang ada yakni tantangan yang ada dalam pelaksanaan kegiatan pendaftaran tanah sistematis lengkap dalam rangka mewujudkan pemberian kepastian hukum. Metode yang digunakan menggunakan metode yuridis empiris. Tantangan yang ada dalam pelaksanaan kegiatan pendaftaran tanah sistematis lengkap dalam rangka mewujudkan pemberian kepastian hukum berupa kendala dan permasalahan yang dihadapi dalam pelaksanaan kegiatan PTSL rendahnya minat keikutsertaan masyarakat, serta kendala dan permasalahan terkait dengan bidang yuridis, dan bidang fisik dalam pelaksanaan kegiatan PTSL. Terdapat pula solusi untuk mengatasi kendala dan permasalahan yang menjadi tantangan tersebut, sehingga dapat mewujudkan kepastian hukum.
Prognostic signature related to the immune environment of oral squamous cell carcinoma
Authors: Hua Yingjie , Sun Xuehui , Luan Kefeng , Wang Changlei 
Published: September 2022

Abstract
Oral squamous cell carcinoma (OSCC) prognosis remains poor. Here we aimed to identify an effective prognostic signature for predicting the survival of patients with OSCC. Gene-expression and clinical data were obtained from the Cancer Genome Atlas database. Immune microenvironment-associated genes were identified using bioinformatics. Subtype and risk-score analyses were performed for these genes. Kaplan–Meier analysis and immune cell infiltration level were explored in different subtypes and risk-score groups. The prognostic ability, independent prognosis, and clinical features of the risk score were assessed. Furthermore, immunotherapy response based on the risk score was explored. Finally, a conjoint analysis of the subtype and risk-score groups was performed to determine the best prognostic combination. We found 11 potential prognostic genes and constructed a risk-score model. The subtype cluster 2 and a high-risk group showed the worst overall survival; differences in survival status might be due to the different immune cell infiltration levels. The risk score showed good performance, independent prognostic value, and valuable clinical application. Higher risk scores showed higher Tumor Immune Dysfunction and Exclusion scores, indicating that patients with a high-risk score were less likely to benefit from immunotherapy. Finally, conjoint analysis for the subgroups and risk groups showed the best predictive ability.