bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defective iron homeostasis and hematological abnormalities in Niemann-Pick disease type C1
Authors: Chen Oscar C W , Siebel Stephan , Colaco Alexandria , Nicoli Elena-Raluca , Platt Nick , Shepherd Dawn , Newman Stephanie , Armitage Andrew E , Farhat Nicole Y , Seligmann George , Smith Claire , Smith David A , Abdul-Sada Alaa , Jeyakumar Mylvaganam , Drakesmith Hal , Porter Forbes D , Platt Frances M 
Published: October 2022

Background: Niemann-Pick disease type C1 (NPC1) is a neurodegenerative lysosomal storage disorder characterized by the accumulation of multiple lipids in the late endosome/lysosomal system and reduced acidic store calcium. The lysosomal system regulates key aspects of iron homeostasis, which prompted us to investigate whether there are hematological abnormalities and iron metabolism defects in NPC1. Methods: Iron-related hematological parameters, systemic and tissue metal ion and relevant hormonal and proteins levels, expression of specific pro-inflammatory mediators and erythrophagocytosis were evaluated in an authentic mouse model and in a large cohort of NPC patients. Results: Significant changes in mean corpuscular volume and corpuscular hemoglobin were detected in Npc1-/- mice from an early age. Hematocrit, red cell distribution width and hemoglobin changes were observed in late-stage disease animals. Systemic iron deficiency, increased circulating hepcidin, decreased ferritin and abnormal pro-inflammatory cytokine levels were also found. Furthermore, there is evidence of defective erythrophagocytosis in Npc1-/- mice and in an in vitro NPC1 cellular model. Comparable hematological changes, including low normal serum iron and transferrin saturation and low cerebrospinal fluid ferritin were confirmed in NPC1 patients. Conclusions: These data suggest loss of iron homeostasis and hematological abnormalities in NPC1 may contribute to the pathophysiology of this disease.
Executives’ Prior Employment Ties to Interlocking Directors and Interfirm Mobility
Authors: Harrison Joseph S. , Boivie Steven , Withers Michael C. 
Published: October 2022

This paper explores how executives’ prior employment ties to interlocking directors, or those who hold additional board seats or executive positions at outside firms, influence individual executive interfirm mobility. As organizational boundary spanners, interlocking directors may be able to influence executive outcomes both within and outside of executives’ current firms. But given natural constraints on internal promotion for executives, we suggest most executives will tend to leverage ties to interlocking directors to access external opportunities, as manifested by movement to outside firms. Analysis of interfirm mobility among a sample of Standard & Poor’s 1500 executives between 2000 and 2014 offer support for this idea. We find a positive association between individual executives’ prior employment ties to interlocking directors and their hazard of movement to outside firms, including to the other firms where these directors serve. At the same time, we argue and find that the strength of this latter relationship will further depend on directors’ competing motivations owing to their specific positions in the focal and interlocking firms. Whereas holding a lead position on the focal firm’s board (i.e., as chairperson or lead independent director) weakens this relationship, holding the position of chief executive officer in the interlocking firm strengthens it. Our theory and findings highlight the unique and important role of interlocking directors in executive interfirm mobility and, in doing so, contribute novel insights regarding how ties to boundary spanners can influence individual outcomes for those to whom they are linked.Supplemental Material: The e-companion is available at https://doi.org/10.1287/orsc.2022.1638 .
One-to-all lightweight Fourier channel attention convolutional neural network for speckle reconstructions
Authors: Lan Botian , Wang Hao , Wang Yangyundou 
Published: October 2022

Speckle reconstruction is a classical inverse problem in computational imaging. Inspired by the memory effect of the scattering medium, deep learning methods reveal excellent performance in extracting the correlation of speckle patterns. Nowadays, advanced models generally include more than 10M parameters and mostly pay more attention to the spatial feature information. However, the frequency domain of images also contains precise hierarchical representations. Here we propose a one-to-all lightweight Fourier channel attention convolutional neural network (FCACNN) with Fourier channel attention and the res-connected bottleneck structure. Compared with the state-of-the-art model, i.e., self-attention armed convolutional neural network (SACNN), our architecture has better feature extraction and reconstruction ability. The Pearson correlation coefficient and Jaccard index scores of FCACNN increased by at least 5.2% and 13.6% compared with task-related models. And the parameter number of the lightweight FCACNN is only 1.15M. Furthermore, the validation results show that the one-to-all model, FCACNN, has excellent generalization capability on unseen speckle patterns such as handwritten letters and Quickdraws.
Ocular findings, surgery details and outcomes in proliferative diabetic retinopathy patients with chronic kidney disease
Authors: Li Jipeng , Chandra Aman , Liu Lin , Zhang Lin , Xu Jun , Zhao Meng 
Published: October 2022

Purpose
We investigated the influence of impaired renal function on fundus characteristics, pars-plana vitrectomy (PPV) details, and outcomes in patients with proliferative diabetic retinopathy (PDR).

Design
A retrospective cohort study

Methods
We investigated a consecutive series of PDR patients who underwent PPV. The diabetic complications, previous photocoagulation, intravitreal injections before PPV, ocular findings during PPV, surgical details, short-term visual outcome and post-PPV complications were recorded and compared between patients with and without impaired renal function.

Results
149 patients had normal renal function (67.7%), and 71 (32.3%) patients had impaired renal function; 85.4% of patients were identified with chronic kidney disease (CKD) during the preoperative assessment. Impaired renal function was related to hypertension (3.40[1.58–7.29], p = 0.002), incomplete pan-retinal photocoagulation (PRP) (3.18[1.50–6.72], p = 0.002), severe fibrovascular membrane (8.19[3.43–19.54], p<0.001), and extensive retinal vascular closure (3.40[1.54–7.52], p = 0.002). There was a more frequent occurrence of severe intraoperative bleeding (56.3%, 32.2%, p = 0.001) and a higher percentage of intraocular subretinal fluid drainage (45.1%, 22.1%, p = 0.008) in patients with impaired renal function. The percentage of patients whose visual acuity (VA) increased was similar between the two groups (42.3%, 54.4%, p = 0.34).

Conclusions
In PDR patients, screening for CKD was required before PPV. PDR patients with impaired renal function tended to have more severe ischemic retinal conditions. Comparable PPV outcomes could be obtained in patients with and without impaired renal damage.
Genome-wide discovery for diabetes-dependent triglycerides-associated loci
Authors: Selvaraj Margaret Sunitha , Paruchuri Kaavya , Haidermota Sara , Bernardo Rachel , Rich Stephen S. , Peloso Gina M. , Natarajan Pradeep 
Published: October 2022

Purpose
We aimed to discover loci associated with triglyceride (TG) levels in the context of type 2 diabetes (T2D). We conducted a genome-wide association study (GWAS) in 424,120 genotyped participants of the UK Biobank (UKB) with T2D status and TG levels.

Methods
We stratified the cohort based on T2D status and conducted association analyses of TG levels for genetic variants with minor allele count (MAC) at least 20 in each stratum. Effect differences of genetic variants by T2D status were determined by Cochran’s Q-test and we validated the significantly associated variants in the Mass General Brigham Biobank (MGBB).

Results
Among 21,176 T2D and 402,944 non-T2D samples from UKB, stratified GWAS identified 19 and 315 genomic risk loci significantly associated with TG levels, respectively. Only chr6p21.32 exhibited genome-wide significant heterogeneity (I2 = 98.4%; pheterogeneity = 2.1x10-15), with log(TG) effect estimates of -0.066 (95%CI: -0.082, -0.050) and 0.002 (95%CI: -0.002, 0.006) for T2D and non-T2D, respectively. The lead variant rs9274619:A (allele frequency 0.095) is located 2Kb upstream of the HLA-DQB1 gene, between HLA-DQB1 and HLA-DQA2 genes. We replicated this finding among 25,137 participants (6,951 T2D cases) of MGBB (pheterogeneity = 9.5x10-3). Phenome-wide interaction association analyses showed that the lead variant was strongly associated with a concomitant diagnosis of type 1 diabetes (T1D) as well as diabetes-associated complications.

Conclusion
In conclusion, we identified an intergenic variant near HLA-DQB1/DQA2 significantly associates with decreased triglycerides only among those with T2D and highlights an immune overlap with T1D.
Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis
Authors: Tan Shing Cheng , Low Teck Yew , Hussain Hafiz Muhammad Jafar , Sharzehan Mohamad Ayub Khan , Sito Hilary , Kord-Varkaneh Hamed , Islam Md Asiful 
Published: October 2022

Background
The XRCC3 p.Thr241Met (rs861539) polymorphism has been extensively studied for its association with glioma risk, but results remain conflicting. Therefore, we performed a systematic review and meta-analysis to resolve this inconsistency.

Methods
Studies published up to June 10, 2022, were searched in PubMed, Web of Science, Scopus, VIP, Wanfang, and China National Knowledge Infrastructure databases and screened for eligibility. Then, the combined odds ratio (OR) of the included studies was estimated based on five genetic models, i.e., homozygous (Met/Met vs. Thr/Thr), heterozygous (Thr/Met vs. Thr/Thr), dominant (Thr/Met + Met/Met vs. Thr/Thr), recessive (Met/Met vs. Thr/Thr + Thr/Met) and allele (Met vs. Thr). The study protocol was preregistered at PROSPERO (registration number: CRD42021235704).

Results
Overall, our meta-analysis of 14 eligible studies involving 12,905 subjects showed that the p.Thr241Met polymorphism was significantly associated with increased glioma risk in both homozygous and recessive models (homozygous, OR = 1.381, 95% CI = 1.081–1.764, P = 0.010; recessive, OR = 1.305, 95% CI = 1.140–1.493, P<0.001). Subgroup analyses by ethnicity also revealed a statistically significant association under the two aforementioned genetic models, but only in the Asian population and not in Caucasians (P>0.05).

Conclusion
We demonstrated that the XRCC3 p.Thr241Met polymorphism is associated with an increased risk of glioma only in the homozygous and recessive models.
Combining the GP’s assessment and the PHQ-9 questionnaire leads to more reliable and clinically relevant diagnoses in primary care
Authors: Teusen Clara , Hapfelmeier Alexander , von Schrottenberg Victoria , Gökce Feyza , Pitschel-Walz Gabriele , Henningsen Peter , Gensichen Jochen , Schneider Antonius ,   for the POKAL-Study-Group
Published: October 2022

Background
Screening questionnaires are not sufficient to improve diagnostic quality of depression in primary care. The additional consideration of the general practitioner’s (GP’s) assessment could improve the accuracy of depression diagnosis. The aim of this study was to examine whether the GP rating supports a reliable depression diagnosis indicated by the PHQ-9 over a period of three months.

Methods
We performed a secondary data analysis from a previous study. PHQ-9 scores of primary care patients were collected at the time of recruitment (t1) and during a follow-up 3 months later (t2). At t1 GPs independently made a subjective assessment whether they considered the patient depressive (yes/no). Two corresponding groups with concordant and discordant PHQ-9 and GP ratings at t1 were defined. Reliability of the PHQ-9 results at t1 and t2 was assessed within these groups and within the entire sample by Cohen’s Kappa, Pearson’s correlation coefficient and Bland-Altman plots.

Results
364 consecutive patients from 12 practices in the region of Upper Bavaria/Germany participated in this longitudinal study. 279 patients (76.6%) sent back the questionnaire at t2. Concordance of GP rating and PHQ-9 at t1 led to higher replicability of PHQ-9 results between t1 and t2. The reliability of PHQ-9 was higher in the concordant subgroup (κ = 0.507) compared to the discordant subgroup (κ = 0.211) (p = 0.064). The Bland-Altman Plot showed that the deviation of PHQ-9 scores at t1 and t2 decreased by about 15% in the concordant subgroup. Pearson’s correlation coefficient between PHQ-9 scores at t1 and t2 increased significantly if the GP rating was concordant with the PHQ-9 at t1 (r = 0.671) compared to the discordant subgroup (r = 0.462) (p = 0.044).

Conclusions
The combination of PHQ-9 and GP rating might improve diagnostic decision making regarding depression in general practices. PHQ-9 positive results might be more reliable and accurate, when a concordant GP rating is considered.
Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study
Authors: Wang Chao , Zhu Yong , Long Haitao , Ou Mingning , Zhao Shushan 
Published: October 2022

PurposeIt has been reported that bone is the primary organ for manganese (Mn) accumulation, but the association between manganese and bone loss remains debatable. Therefore, this study aimed to evaluate the relationship between blood manganese and bone mineral density/bone mineral content (BMD/BMC) by using a representative sample from the National Health and Nutrition Examination Survey (NHANES).MethodsA total of 9732 subjects over the age of 18 with available data were enrolled in this study. The relationship between blood manganese and BMD/BMC of the total body, spine and femoral regions was evaluated using multivariate linear regression models. Subgroup analyses were also performed.ResultsWe observed a negative association between blood manganese and BMD/BMC in the femoral neck and total body in the fully adjusted model, especially femoral neck BMD in women aged 50–70 years.ConclusionIn brief, people exposed to manganese should be aware of the increased risk of osteopenia or osteoporosis. Besides, due to the lack of available data, there are no definite values for the tolerable upper intake level (UL), average requirement (AR) and population reference intake (PRI) of manganese. The results of our study may provide some references for the establishment of AR, PRI and UL of Mn.
A clinical study of thread carpal tunnel release with a newly developed thread: A retrospective pilot study
Authors: Park Jisoo , Kim In Jong , Park Hae-yeon , Heo Dong jin , Kim Jae Min 
Published: October 2022

Introduction
Previous studies have shown that, thread carpal tunnel release (TCTR), an ultrasound-guided transverse carpal ligament (TCL) transection procedure through needle and thread, to be a safe and effective technique for carpal tunnel release, compared to an open and endoscopic technique. We developed a newly improved thread (Smartwire-01, 0.27mm in diameter, Korea). This pilot study was performed to propose the effectiveness of TCTR with Smartwire-01 compared to the commercial thread in clinical settings.

Methods
A total of 22 TCTR procedures have been performed on 19 patients by one physiatrist during a 42-month period. The diagnosis of carpal tunnel syndrome was based on standard clinical criteria including electromyography (EMG). Patients were divided into two groups, one dissected with commercial thread and the other with Smartwire-01. The technique was standardized by keeping the entry point at the middle of the palm and the exit point at just medial to the palmaris longus tendon. The Numeric Rating Scale and Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) were used to assess monthly outcomes for 6 months following the procedure. The Wilcoxon signed rank test and the Mann-Whitney-U test were performed to analyze the above variables in the two groups.

Results
There was no definite evidence that the two groups have significant differences for any of the surveyed variables. The TCTR procedure with our newly developed thread also had significant improvements for all variables, showing its effectiveness in both pain and functional ability. The NRS and BCTQ severity and functional scales showed significant decreases just after the dissection and progressive improvement during each monthly follow-up of our study until the last assessment at 6 months.

Conclusion
The study suggests that, our newly developed thread is as safe and effective as the commercial thread in TCTR, we therefore recommend a randomize controlled trial with above methodology.
Physical activity and body composition in patients with rheumatoid arthritis
Authors: Dobrovolskaya O. V. , Toroptsova N. V. , Feklistov A. Yu. , Demin N. V. , Nikitinskaya O. A. 
Published: October 2022

Objective: to evaluate physical activity (PA) and its relationship with body composition in patients with rheumatoid arthritis (RA).Patients and methods. The study included 93 women with RA. A standardized questionnaire survey, anthropometric measurements, laboratory work up, and dual-energy x-ray absorptiometry were conducted to assess body composition and bone mineral density. The level of PA was determined using the International Physical Activity Questionnaire (IPAQ).Results and discussion. The IPAQ survey showed that 46 (49.5%), 41 (44.1%) and 6 (6.4%) patients had high, moderate and low levels of PA, respectively. The patients did not differ in clinical and anamnestic, laboratory and instrumental data depending on the level of PA. Correlations were found between total energy expenditure by IPAQ and daily food calcium intake (r=0.26, p=0.012), shoulder circumference (r=0.22, p=0.042) and postmenopausal duration (r=-0.27, p=0.016). The relationship between the sarcopenic phenotype (SP) and the time of vigorous physical activity less than 15 minutes per day was revealed (odds ratio, OR 6.31; 95% confidence interval, CI 1.75–22.71; p=0.004), between the frequency of moderate physical exercise and walking less than 4 times a week (OR 4.09; 95% CI 1.16–14.47; p=0.027 and OR 4.73; 95% CI 1.24–18.07; p=0.021, respectively), the presence of osteoporosis – OD (OR 9.41; 95% CI 2.73–32.47; p <0.001). The risk of obesity increased with vigorous exercise less than 15 minutes per day (OR 3.03; 95% CI 1.11–8.29; p=0.029). The osteoporotic phenotype (OPP) was associated with patient age (OR 1.12; 95% CI 1.05–1.19; p=0.001) and the presence of SP (OR 8.97; 95% CI 2.39– 33.60; p=0.001).Conclusion. Half of the patients had moderate and low level of PA, independent of age, RA duration and activity. SP was associated with insufficient PA and the presence of OPP. Obesity is also associated with lack of PA, while OPP is associated with age and the presence of SP.
Kajian Anatomi-Histokimia Tangkai Daun dan Karakteristik Epidermis Pucuk Merah (Syzygium myrtifolium Walpp. – Myrtaceae)
Authors: Sofiyanti Nery , Iriani Dyah , Lestari Asri Ria 
Published: October 2022

Tanaman pucuk merah (Syzygium myrtifolium Walp.) merupakan salah satu tanaman yang termasuk dalam famili Myrtaceae. Penelitian ini bertujuan melakukan kajian anatomi-histokimia petiole dan karakteristik epidermis daun pucuk merah. Sampel yang diambil adalah daun pucuk merah yang sudah dewasa. Penelitian ini dilakukan pada bulan April sampai Juni 2022. Pembuatan preparat anatomi dilakukan dengan metode parafin, sedangkan uji histokimia dilakukan pada senyawa alkaloid, tanin, flavonoid, dan lipid dengan metode kualitatif. Pengamatan karakteristik epidermis dilakukan dengan metode paradermal. Hasil pengamatan anatomi penampang melintang petiole pucuk merah menunjukan bentuk agak oval, membulat pada bagian dorsal dan bersayap pada bagian ventral. Kutikula terdapat di sebelah luar epidermis. Korteks terdiri dari lapisan hipodermis dan parenkim. Hipodermis tersusun dari 4 – 5 lapisan sel-sel kolenkim memanjang, dan terdapat rongga sekresi berisi minyak. Parenkim tersusun dari 17 – 19 sel sel poligonal. Berkas pembuluh berada di tengah dengan tipe bikolateral. Hasil uji histokimia petiole menunjukkan hasil positif flavonoid, alkaloid, tanin, dan lipid. Stomata pucuk merah termasuk hipostomatik dengan tipe parasitik. Sel-sel epidermis poligonal dengan dinding sel bergelombang (undulate). Hasil kajian ini memberikan informasi tambahan mengenai anatomi, histokimia dari petiolus pucuk merah serta memberikan informasi karakteristik epidermis dan stomata tanaman ini. The red tip plant (Syzygium myrtifolium Walp.) belongs to Myrtaceae family. The aim of this study was to investigate the anatomical-histochemical of ptiole as well as epidermal chrakteristic of red tip plant. Leaf samples were collected sixth node from the top. This study had been conducted from April to June 2022. The anatomical preparation used paraffine method. Histochemistry test was carried out for alkaloid, tannin, flavonoid and lipid using qualitative method. Epidermal charateristic was observed using paradermal method. The anatomical result shows that the cross section of petiole of red tip plant is slightly ovale-shaped, with rounded part at dorsal side dan winged-part at ventral side. The outermost part is cuticle layer. Cortex is consisted of hipoderm and parenchyma layers. Hipoderm is arranged by 4 to 5 layers of elongated cholencym cells, with secretion structure or oil gland. Parenchym is consisted of 17 – 19 layers of polygonal cells. Vascular bundle is located in the center, with bicholateral type. The histochemistry test indicated positive content of flavonoid, alkaloid, tannin and lipid. The stomata of red tip plant is hypostomatic with paracytic type. The epiderm cells are polygonal with undulate cell walls.The result of this study provide the additional information of anatomy, histochemistry of petiole of red tip land, and also provide the information of epidermal characteristic of this plant.
Implementation of Dengue Hemorrahagic Fever (DHF) Case Reporting in Buleleng District
Authors: Arista I Gede Peri , Sawitri Anak Agung Sagung , Yatra I Made Suganda 
Published: October 2022

Background: Reporting cases of Dengue Hemorrhagic Fever (DHF) based on case definition the Ministry of Health of the Republic Indonesia is a strategy to increase the ability to predict positive cases. Our study aims to examine the implementation of case reporting so as to improve the predictive ability of positive cases.Methods: We conducted operational research at Kertha Usada General Hospital and Buleleng District Hospital. The sample is individuals diagnosed with DHF by a hospital having their address in Buleleng District and undergoing inpatient treatment at Kertha Usada General Hospital and Buleleng District Hospital in the first week of October 2021. We collected data through a review of medical record documents using a checklist.Result: We evaluated among 10 cases, 6 cases (60.0%) of whom were over 12 years old and 7 cases (70.0%) were men. Based on clinical indicators, among 10 cases, all cases (100%) actually had fever between 2-7 days, 5 cases (50%) really had headaches, 4 cases (40%) really had abdominal pain and 8 cases (80%) actually vomiting. Based on laboratory indicators, among all 10 cases (100%) there was a decrease in platelets <100,000 u/L and in 1 case (10%) there was an increase in hematocrit >52%.Conclusion : The positive predictive value obtained is 100% with very good positive predictive ability. Reporting cases based on the Ministry of Health of the Republic Indonesia case definition is expected to be carried out an ongoing basis because it can improve the ability to predict positive cases. Periodic training and technical guidance are required to equalize perceptions of case definitions so as to improve reporting quality.