bluuebunny/crossref_metadata_2025_split huggingface dataset:
New court, same division: The Bemba case as an illustration of the continued confusion regarding the command responsibility doctrine
Authors: O’Sullivan Carmel 
Published: May 2022

AbstractProsecutor v. Jean-Pierre Bemba Gombo was the International Criminal Court’s first case directly addressing the command responsibility doctrine. As the first permanent international criminal court who can exercise jurisdiction over a majority of the world’s nation states, its interpretation of the doctrine was potentially an important development in international criminal law and an opportunity to affirm the legal responsibility of commanders for their subordinates’ crimes. However, rather than providing a clear articulation of the doctrine and its scope, the Appeals Chamber was split. By a 3–2 majority, it reversed the Trial Chamber’s decision and the Appeals Chamber’s judges were sufficiently divided in their reasoning that they felt compelled to deliver separate opinions.A key disagreement within the doctrine is whether command responsibility is a mode of liability or a separate offence of dereliction of duty. This disagreement feeds into further contestation about the doctrine’s core elements, including the standard of fault necessary under its actus reus or mens rea elements. This article examines the judges’ reasoning in Bemba to illustrate that, despite decades of jurisprudence and academic debate, there is still confusion on these foundational elements. Instead of being ‘settled law’, the debate on command responsibility is still live. The article maintains that the current law supports a mode of liability interpretation but proposes that reclassifying the doctrine as a separate offence could resolve many of its tensions while observing the culpability principle, satisfying its justifications, and facilitating an adequately wide scope of accountability.
Displaying the Magician's Art: Theatrical Illusion in Ingmar Bergman's The Magic Flute (1975)
Authors: Ibáñez-García Estela 
Published: May 2022

AbstractIngmar Bergman's The Magic Flute is a film that not only represents a performance of Mozart's opera but also reflects on the experience it generates in the theatrical audience. The opera becomes the means through which Bergman explores the magic of theatrical illusion by displaying the artifice behind it. I examine the film's take on the representation of theatrical illusion from two perspectives. First, with reference to the famous sequence of the overture, I demonstrate the crucial role of the audience's imaginative engagement. Second, I zero in on Bergman's role as omniscient director who not only uncovers the artificiality of the theatrical source but also plays tricks with the film audience. Yet our observing the ‘constructed naturalness’ of the magic flute and Papageno or the theatricality of the Queen of the Night's performance does not hinder the film's ability to engage us. Rather, witnessing the workings of illusion strengthens its grip on us.
FRIENDSHIP AND THE WISHES OF THE DEAD
Authors: Dorsey Dale 
Published: May 2022

ABSTRACTThe wishes of the dead seem to have normative significance. We not only respect last wills and testaments, but we take seriously what the dead loved, what they valued, even after they have long escaped this mortal coil. But this presents a philosophical puzzle. Is this a normatively justified practice? Why should the fact that some dead person preferred state of affairs x to state of affairs y be a reason to bring about x rather than y—especially if there is otherwise reason to promote y rather than x? In this paper, I argue that extant solutions to this problem are inadequate and propose an alternative. I argue that the normative significance of the wishes of the dead is to be found not in the dead's well-being or interests, but instead in the relations of friendship we bear to the dead.
Terrorist campaigns and the growth of the Muslim population: a reply to Clara Egger and Raul Magni-Berton
Authors: Choi Seung-Whan 
Published: May 2022

AbstractI am delighted to see that my study on the effect of terrorist campaigns on the growth of Muslim populations has intrigued Egger and Magni-Berton. After discussing potential theoretical and methodological shortcomings in my study, Egger and Magni-Berton conclude that there is no empirical support for the positive relationship between terror attacks and Muslim populations. Their approach of separating terrorism into Islamist and non-Islamist terrorism is an effort to advance the contemporary research on the nexus between terrorism and Islam. In this re-examination, I show that Egger and Magni-Berton's conclusion is based on two limitations: theoretically unfounded and empirically inadequate. After remedying these limitations step by step, I reconfirm that a series of terrorist activities collectively serve as an explanation for the growth of the worldwide Muslim population. Future research can offer additional evidence to understand whether there is a significant and positive relationship between Islamist terrorism and the growth of Muslim populations.
The Web-Based Assessment of Mental Speed
Authors: Gnambs Timo 
Published: May 2022

Abstract: Although web-based cognitive assessments have gained increasing attention in recent decades, it is still debated whether unstandardized test settings allow for comparable measurements as compared to proctored testing, particularly for speeded cognitive tests. Therefore, two within-subject experiments ( N = 73 and N = 72) compared differences in means, criterion correlations with measures of intelligence, and subjective test quality perceptions of a trail-making test between a proctored paper-based, a proctored computerized, and an unproctored web-based administration mode. The results in both samples showed equivalent means between the two computerized modes, equivalent criterion correlations between the three modes, and no differential item functioning. However, the web-based tests were rated as having an inferior measurement quality as compared to the proctored assessments. Thus, web-based testing allows for comparable measurements of mental speed as compared to traditional computerized tests, although it is still regarded as a lower quality medium by test takers.
Alternate Histories: Synthetic Large Ensembles of Sea‐Air CO2 Flux
Authors: Olivarez Holly C. , Lovenduski Nicole S. , Brady Riley X. , Fay Amanda R. , Gehlen Marion , Gregor Luke , Landschützer Peter , McKinley Galen A. , McKinnon Karen A. , Munro David R. 
Published: May 2022

AbstractWe use a statistical emulation technique to construct synthetic ensembles of global and regional sea‐air carbon dioxide (CO2) flux from four observation‐based products over 1985–2014. Much like ensembles of Earth system models that are constructed by perturbing their initial conditions, our synthetic ensemble members exhibit different phasing of internal variability and a common externally forced signal. Our synthetic ensembles illustrate an important role for internal variability in the temporal evolution of global and regional CO2 flux and produce a wide range of possible trends over 1990–1999 and 2000–2009. We assume a specific externally forced signal and calculate the rank of the observed trends within the distribution of statistically modeled synthetic trends during these periods. Over the decade 1990–1999, three of four observation‐based products exhibit small negative trends in globally integrated sea‐air CO2 flux (i.e., enhanced ocean CO2 absorption with time) that are within one standard deviation of the mean in their respective synthetic ensembles. Over the decade 2000–2009, however, three products show large negative trends in globally integrated sea‐air CO2 flux that have a low rate of occurrence in their synthetic ensembles. The largest positive trends in global and Southern Ocean flux over 1990–1999 and the largest negative trends over 2000–2009 fall nearly two standard deviations away from the mean in their ensembles. Our approach provides a new perspective on the important role of internal variability in sea‐air CO2 flux trends, and furthers understanding of the role of internal and external processes in driving observed sea‐air CO2 flux variability.
On the Occurrence of Magnetic Reconnection Along the Terrestrial Magnetopause, Using Magnetospheric Multiscale (MMS) Observations in Proximity to the Reconnection Site
Authors: Petrinec S. M. , Burch J. L. , Fuselier S. A. , Trattner K. J. , Giles B. L. , Strangeway R. J. 
Published: May 2022

AbstractObservations at the reconnection site from the Magnetospheric Multiscale mission are used to examine the occurrence of magnetic reconnection along the magnetopause in relation to both the upstream interplanetary magnetic field (IMF) orientation and local magnetosheath variations. While there is a statistically larger number of reconnection intervals observed downstream of the quasi‐parallel bow shock than is accounted for based on the histogram of overall IMF orientations, it is surmised that increased fluctuations downstream of the quasi‐parallel bow shock cause greater large‐scale motion of the magnetopause surface; but do not preferentially enhance the occurrence of steady magnetic reconnection. An examination of the locations of observed reconnection sites relative to model predictions also suggest that enhanced magnetosheath fluctuations do not result in steady reconnection occurring at random locations at the magnetopause.
Wind‐Induced Hypolimnetic Upwelling Between the Multi‐Depth Basins of Lake Geneva During Winter: An Overlooked Deepwater Renewal Mechanism?
Authors: Reiss Rafael S. , Lemmin U. , Barry D. A. 
Published: May 2022

AbstractCombining field observations, 3D hydrodynamic modeling, and particle tracking, we investigated wind‐induced interbasin exchange between the Petit Lac (PL) (depth 75 m) and Grand Lac (GL) (depth 309 m) basins of Lake Geneva in early winter. Following a strong 2.5‐day wind event, a two‐layer flow field developed, where the downwind surface drift into the GL was balanced by counterflowing hypolimnetic currents into the PL. Velocities in both layers exceeded 20 cm s−1, with the highest values (27 cm s−1) found near the bottom. For 3.5 days, hypolimnetic temperatures at the confluence decreased to values found in the deep GL hypolimnion at 180‐m depth. Approximately 1.5 days after the wind event ceased, currents reversed and upwelled waters returned into the deep GL hypolimnion. The Coriolis force strongly modified the interbasin exchange dynamics, which were well represented by the model. Particle tracking revealed a “current loop,” that is, water from below 150‐m depth first upwelled into the PL, intruded approximately 10 km (half its length), and then descended back into the GL hypolimnion. Model results showed that the PL hypolimnetic volume doubled during the upwelling. Low model‐based gradient Richardson numbers and temperature inversions in CTD profiles indicated turbulent mixing between the upwelled GL and surrounding PL waters. Our findings demonstrate that hypolimnetic upwelling between the two basins frequently occurs during winter and could potentially be an important, but as yet overlooked mechanism for hypolimnetic‐epilimnetic exchange and deepwater renewal in Lake Geneva, and probably in other multi‐depth basin lakes under similar wind conditions.
Tracking Global Patterns of Drought‐Induced Productivity Loss Along Severity Gradient
Authors: Wang Yiheng , Fu Zheng , Hu Zhongmin , Niu Shuli 
Published: May 2022

AbstractDroughts significantly impact land carbon uptake by reducing the gross primary productivity (GPP). Projections suggest an increase in severe and extreme droughts in the twenty‐first century. Despite the importance of droughts on carbon uptakes, it remains unclear about the GPP responses under different drought severity and its changes under current climate changes. Using four state‐of‐the‐science GPP products, we showed that moderate (−1 ≤ SPEI < −1.5), severe (−1.5 ≤ SPEI < −2), and extreme (SPEI < −2) droughts caused on average 5%, 7%, and 9% GPP reductions, respectively, across the globe during the recent decades. Although the mean reductions varied among GPP products, we observed similar spatial patterns. The reductions increased significantly along the severity gradient, while the sharpest increases were observed in semi‐arid and grassland ecosystems. On a biome level, we found that the reductions increased nonlinearly with increasing drought severities for almost all vegetation types, but the trends and slopes varied significantly. In addition, we found that the mean drought‐induced GPP reductions had increased in dry ecosystems but decreased in humid ecosystems from 2001–2008 to 2009–2016. The result highlights the potential increase of drought‐induced land carbon sink loss responding to more extreme climates and offers new perspectives to improve the prediction of global carbon fluxes in a changing climate.
A Hybrid Statistical Downscaling Framework Based on Nonstationary Time Series Decomposition and Machine Learning
Authors: Li Xintong , Zhang Xiaodong , Wang Shuguang 
Published: May 2022

AbstractDownscaling techniques are effective to bridge the scale gap between global circulation models and regional studies. Statistical downscaling methods are prevalent due to their advantages in high computational efficiency and accuracy. However, an implicit assumption of most statistical techniques is that time series should be relatively stationary after certain function transformations. Otherwise, statistics of nonstationary time series may be meaningless for describing future behavior. In this study, a hybrid statistical downscaling framework was developed through integrating bivariate empirical mode decomposition (BEMD) and a machine learning method to extract multi‐timescale features from nonstationary data to enhance downscaling performance. The proposed framework can reduce the effects of non‐stationarity in data‐driven models by using the BEMD method, which can decompose time series into independent and stationary components at multiple time‐frequency resolutions. It was applied to downscale monthly precipitation and temperature of Canadian Earth System Model in multiple stations with different climate types in the Central Valley of California, USA, to verify its accuracy and generalization ability. The performance of downscaling maximum and minimum temperatures (R2 > 0.9) was more accurate than that of precipitation. The potential reason is that precipitation is more sensitive to transient weather phenomena, which can only be extracted from data with higher temporal resolution. The proposed model was further compared with models based on discrete wavelet transform and models without time series decomposition. The results showed that a decomposition strategy of the proposed framework can improve the downscaling accuracy, potentially providing a viable option to deal with the nonstationary of data in statistical downscaling models.
Simultaneous Observations of a Polar Cap Sporadic‐E Layer by Twin Incoherent Scatter Radars at Resolute
Authors: Wang Yong , Themens David R. , Wang Cheng , Ma Yu‐Zhang , Reimer Ashton , Varney Roger , Gilies Robert , Xing Zan‐Yang , Zhang Qing‐He , Jayachandran P. T. 
Published: May 2022

AbstractAt high latitudes, the Sporadic‐E layer (Es layer) is a common phenomenon but is still poorly understood due to sparse measurements and the difficulty of conventional mechanisms to operate. In this study, an interesting case of polar cap Es layer is first studied by using the twin incoherent scatter radars (northward‐looking face of Resolute Incoherent‐Scatter Radar and Resolute Incoherent‐Scatter Radar‐Canada), a Canadian Advanced Digital Ionosonde, and a Magnetometer, all at Resolute, Canada. From several electron density profiles of the twin radars, the horizontal scale of the polar cap Es layer is found to be greater than 350 km. Moreover, the polar cap Es layer is determined to be drifting from the bottom F region (>150 km) to the lower E region. Furthermore, a unique appearance of double polar cap Es layers is observed. As a result, these peculiar signatures inspire a newly proposed process that involves the combination of localized electric fields and gravity waves.
Topologically tuned terahertz confinement in a nonlinear photonic chip
Authors: Wang Jiayi , Xia Shiqi , Wang Ride , Ma Ruobin , Lu Yao , Zhang Xinzheng , Song Daohong , Wu Qiang , Morandotti Roberto , Xu Jingjun , Chen Zhigang 
Published: May 2022

AbstractCompact terahertz (THz) functional devices are greatly sought after for high-speed wireless communication, biochemical sensing, and non-destructive inspection. However, controlled THz generation, along with transport and detection, has remained a challenge especially for chip-scale devices due to low-coupling efficiency and unavoidable absorption losses. Here, based on the topological protection of electromagnetic waves, we demonstrate nonlinear generation and topologically tuned confinement of THz waves in an engineered lithium niobate chip forming a wedge-shaped Su–Schrieffer–Heeger lattice. Experimentally measured band structures provide direct visualization of the THz localization in the momentum space, while robustness of the confined mode against chiral perturbations is also analyzed and compared for both topologically trivial and nontrivial regimes. Such topological control of THz waves may bring about new possibilities in the realization of THz integrated circuits, promising for advanced photonic applications.
Scalable high-repetition-rate sub-half-cycle terahertz pulses from spatially indirect interband transitions
Authors: Meineke Christian , Prager Michael , Hayes Johannes , Wen Qiannan , Kastner Lukas Zheyi , Schuh Dieter , Fritsch Kilian , Pronin Oleg , Stein Markus , Schäfer Felix , Chatterjee Sangam , Kira Mackillo , Huber Rupert , Bougeard Dominique 
Published: May 2022

AbstractIntense phase-locked terahertz (THz) pulses are the bedrock of THz lightwave electronics, where the carrier field creates a transient bias to control electrons on sub-cycle time scales. Key applications such as THz scanning tunnelling microscopy or electronic devices operating at optical clock rates call for ultimately short, almost unipolar waveforms, at megahertz (MHz) repetition rates. Here, we present a flexible and scalable scheme for the generation of strong phase-locked THz pulses based on shift currents in type-II-aligned epitaxial semiconductor heterostructures. The measured THz waveforms exhibit only 0.45 optical cycles at their centre frequency within the full width at half maximum of the intensity envelope, peak fields above 1.1 kV cm−1 and spectral components up to the mid-infrared, at a repetition rate of 4 MHz. The only positive half-cycle of this waveform exceeds all negative half-cycles by almost four times, which is unexpected from shift currents alone. Our detailed analysis reveals that local charging dynamics induces the pronounced positive THz-emission peak as electrons and holes approach charge neutrality after separation by the optical pump pulse, also enabling ultrabroadband operation. Our unipolar emitters mark a milestone for flexibly scalable, next-generation high-repetition-rate sources of intense and strongly asymmetric electric field transients.
Personalised selection of experimental treatment in patients with advanced solid cancer is feasible using whole-genome sequencing
Authors: Pruis Melinda A. , Groenendijk Floris H. , Badloe K. Sangeeta , van Puffelen Andrea , Robbrecht Debbie , Dinjens Winand N. M. , Sleijfer Stefan , Dingemans Anne-Marie C. , von der Thüsen Jan H. , Roepman Paul , Lolkema Martijn P. 
Published: May 2022

Abstract
Background
Biomarker-guided therapy in an experimental setting has been suggested to improve patient outcomes. However, trial-specific pre-screening tests are time and tissue consuming and complicate the personalised treatment of patients eligible for early-phase clinical trials. In this study the feasibility of whole-genome sequencing (WGS) as a one-test-for-all for guided inclusion in early-phase trials was investigated.

Methods
Phase I Molecular Tumor Board (MTB) at the Erasmus MC Cancer Institute reviewed patients with advanced cancer without standard-of-care treatment (SOC) options for a ‘fresh-frozen’ (FF) tumour biopsy for WGS based on clinical-pathological features. Clinical grade WGS was performed by Hartwig Medical Foundation. MTB matched the patient with a trial, if available.

Results
From September 2019–March 2021, 31 patients with highly diverse tumour types underwent a tumour biopsy for WGS. The median turnaround time (TAT) was 15 days [10–42 days]. At least one actionable event was found in 84% of the patients (26/31). One-third of the patients (11/31) received matched experimental treatment.

Conclusions
WGS on fresh FF biopsies is a feasible tool for the selection of personalised experimental therapy in patients with advanced cancer without SOC options. WGS is now possible in an acceptable TAT and thus could fulfil the role of a universal genomic pre-screening test.
Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy
Authors: van Beijnum Judy R. , Huijbers Elisabeth J. M. , van Loon Karlijn , Blanas Athanasios , Akbari Parvin , Roos Arno , Wong Tse J. , Denisov Stepan S. , Hackeng Tilman M. , Jimenez Connie R. , Nowak-Sliwinska Patrycja , Griffioen Arjan W. 
Published: May 2022

AbstractAnti-angiogenic cancer therapies possess immune-stimulatory properties by counteracting pro-angiogenic molecular mechanisms. We report that tumor endothelial cells ubiquitously overexpress and secrete the intermediate filament protein vimentin through type III unconventional secretion mechanisms. Extracellular vimentin is pro-angiogenic and functionally mimics VEGF action, while concomitantly acting as inhibitor of leukocyte-endothelial interactions. Antibody targeting of extracellular vimentin shows inhibition of angiogenesis in vitro and in vivo. Effective and safe inhibition of angiogenesis and tumor growth in several preclinical and clinical studies is demonstrated using a vaccination strategy against extracellular vimentin. Targeting vimentin induces a pro-inflammatory condition in the tumor, exemplified by induction of the endothelial adhesion molecule ICAM1, suppression of PD-L1, and altered immune cell profiles. Our findings show that extracellular vimentin contributes to immune suppression and functions as a vascular immune checkpoint molecule. Targeting of extracellular vimentin presents therefore an anti-angiogenic immunotherapy strategy against cancer.
Synthesis and macrocyclization-induced emission enhancement of benzothiadiazole-based macrocycle
Authors: Li Shuo , Liu Kun , Feng Xue-Chen , Li Zhao-Xian , Zhang Zhi-Yuan , Wang Bin , Li Minjie , Bai Yue-Ling , Cui Lei , Li Chunju 
Published: May 2022

AbstractWe presented an effective and universal strategy for the improvement of luminophore’s solid-state emission, i.e., macrocyclization-induced emission enhancement (MIEE), by linking luminophores through C(sp3) bridges to give a macrocycle. Benzothiadiazole-based macrocycle (BT-LC) has been synthesized by a one-step condensation of the monomer 4,7-bis(2,4-dimethoxyphenyl)−2,1,3-benzothiadiazole (BT-M) with paraformaldehyde, catalyzed by Lewis acid. In comparison with the monomer, macrocycle BT-LC produces much more intense fluorescence in the solid state (ΦPL = 99%) and exhibits better device performance in the application of OLEDs. Single-crystal analysis and theoretical simulations reveal that the monomer can return to the ground state through a minimum energy crossing point (MECPS1/S0), resulting in the decrease of fluorescence efficiency. For the macrocycle, its inherent structural rigidity prohibits this non-radiative relaxation process and promotes the radiative relaxation, therefore emitting intense fluorescence. More significantly, MIEE strategy has good universality that several macrocycles with different luminophores also display emission improvement.