bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ‘other’ big complication: how chronic kidney disease impacts on cancer risks and outcomes
Authors: Lees Jennifer S , Elyan Benjamin M P , Herrmann Sandra M , Lang Ninian N , Jones Robert J , Mark Patrick B 
Published: January 2022

ABSTRACT
Cancer is the second leading cause of death in people with chronic kidney disease (CKD) after cardiovascular disease. The incidence of CKD in patients with cancer is higher than in the non-cancer population. Across various populations, CKD is associated with an elevated risk of cancer incidence and cancer death compared with people without CKD, although the risks are cancer site-specific. Higher risk of cancer is detectable in mild CKD [estimated glomerular filtration rate (eGFR) 60–89 mL/min/1.73 m2], although this risk is more obvious if sensitive markers of kidney disease are used, such as cystatin C. Independent of eGFR, albuminuria is associated with increased risk of site-specific cancer incidence and death. Here, we explore the potential mechanisms for the increased risk of cancer observed in CKD, including patient factors (shared risks such as cardiometabolic disease, obesity, smoking, diet, lifestyle and environment), disease (genetic, inflammatory and infective) and treatment factors. In particular, we discuss the ways in which renal adverse events associated with conventional chemotherapies and newer systemic anti-cancer therapies (including targeted and immunotherapies) may contribute to worse cancer outcomes in people with CKD. Finally, we review the potential benefits of acknowledging increased risk of cancer in risk prediction tools used for the management of CKD.
Adams–Oliver syndrome, intestinal obstruction and heart defects: a case series of aplasia cutis congenita
Authors: Baroudi Ihsan , Alakhras Ola , Douri Thaer , Alkhani Nedal 
Published: January 2022

ABSTRACT
Aplasia cutis congenita (ACC) is a rare congenital defect described by the absence of skin and occasionally subcutaneous tissues or bone. The management of ACC varies depending on the lesion size, location and associated abnormalities. Small lesions often heal spontaneously, whereas larger lesions are significant and usually associated with additional anomalies in other organs. This paper reports three cases, which describe large lesions of ACC, presented with other abnormalities (Adams–Oliver syndrome, intestinal obstruction and heart defect). Particular attention should be paid to the patient with large lesions of ACC to investigate more congenital anomalies.
COVID-19-positivity in a heart transplant recipient—antibody-mediated rejection or SARS-CoV-2-associated cardiac injury?
Authors: Hanson Paul J , Liu-Fei Felicia , Lai Chi , Toma Mustafa , McManus Bruce M 
Published: January 2022

ABSTRACT
Through the ongoing and heightening coronavirus disease 2019 (COVID-19) pandemic, the heart has been implicated as a central target of injury associated with significantly increased morbidity and mortality. Correspondingly, heart transplant recipients are a vulnerable population for which insufficient research has been conducted. Pathologic antibody-mediated rejection (pAMR) of cardiac allografts shares many characteristics with COVID-19-associated cardiac injury. In this case study, we investigate a 57-year-old female who contracted COVID-19 11 days postheart transplant and was observed to have pAMR while positive for laboratory-confirmed COVID-19, resulting in a diagnostic conundrum.
Conceptualizing and Theorizing the Indigenous Lifeworld
Authors: Walter Maggie 
Published: January 2022

Abstract
The Euro-industrial revolution, large-scale Anglo colonization, and the emergence of sociology all emanate from similar societal origins and time in history. Yet despite these shared roots, the impact of colonization on societies or on Indigenous Peoples is almost completely absent from sociological theorizing, even in colonized First Nation states such as Australia. But with colonization, the pivotal social issue for colonized Indigenous Peoples, then and now, a sociology without colonization is not an option for Indigenous sociologists. This chapter emphasizes this centrality through an embodied conceptualization and operationalization of distinctive Indigenous lived realities. Using the author’s Palawa lifeworld as the case study, it demonstrates the intertwined intersubjectivities of Indigenous peoplehood and of Indigenous colonized marginalization that make up the Indigenous lifeworld. In doing so, it also demonstrates that a sociology practiced without acknowledging colonization is, at its essence, flawed.
Reading Tovey’s Essays as Public Music Theory
Authors: Pearson Robert D. 
Published: January 2022

Abstract
Tovey’s anthology of program notes, the six-volume Essays in Musical Analysis, have become important texts in the history of music scholarship, yet their origin as program notes is sometimes overlooked because of analytical values that characterize later music scholarship. Diverse audiences used Tovey’s program notes in varied ways, requiring scholars to approach the notes in light of both their audiences and the history of music theory. This chapter uses the program note for Beethoven’s Overture to The Consecration of the House to consider the kinds of musical needs that Tovey’s program notes meet. It also discusses how that program note uses narrative strategies, in the form of three stories it tells, to help Tovey’s musical ideas negotiate the cultural and musical contexts of their milieus. Along the way, the chapter tries to understand Tovey’s writings on their own terms as artifacts of what we might call public music theory.
Reductive stress triggers ANAC017-mediated retrograde signaling to safeguard the endoplasmic reticulum by boosting mitochondrial respiratory capacity
Authors: Fuchs Philippe , Bohle Finja , Lichtenauer Sophie , Ugalde José Manuel , Feitosa Araujo Elias , Mansuroglu Berivan , Ruberti Cristina , Wagner Stephan , Müller-Schüssele Stefanie J , Meyer Andreas J , Schwarzländer Markus 
Published: January 2022

AbstractRedox processes are at the heart of universal life processes, such as metabolism, signaling, or folding of secreted proteins. Redox landscapes differ between cell compartments and are strictly controlled to tolerate changing conditions and to avoid cell dysfunction. While a sophisticated antioxidant network counteracts oxidative stress, our understanding of reductive stress responses remains fragmentary. Here, we observed root growth impairment in Arabidopsis thaliana mutants of mitochondrial alternative oxidase 1a (aox1a) in response to the model thiol reductant dithiothreitol (DTT). Mutants of mitochondrial uncoupling protein 1 (ucp1) displayed a similar phenotype indicating that impaired respiratory flexibility led to hypersensitivity. Endoplasmic reticulum (ER) stress was enhanced in the mitochondrial mutants and limiting ER oxidoreductin capacity in the aox1a background led to synergistic root growth impairment by DTT, indicating that mitochondrial respiration alleviates reductive ER stress. The observations that DTT triggered nicotinamide adenine dinucleotide (NAD) reduction in vivo and that the presence of thiols led to electron transport chain activity in isolated mitochondria offer a biochemical framework of mitochondrion-mediated alleviation of thiol-mediated reductive stress. Ablation of transcription factor Arabidopsis NAC domain-containing protein17 (ANAC017) impaired the induction of AOX1a expression by DTT and led to DTT hypersensitivity, revealing that reductive stress tolerance is achieved by adjusting mitochondrial respiratory capacity via retrograde signaling. Our data reveal an unexpected role for mitochondrial respiratory flexibility and retrograde signaling in reductive stress tolerance involving inter-organelle redox crosstalk.
The Correlates and Characteristics of American State Identity
Authors: Pears Emily , Sydnor Emily 
Published: January 2022

AbstractThe Federalist Papers highlight the role that citizens’ state identities will play in American federalism, yet some scholars argue that contemporary Americans have shed their state attachments. Drawing on data from a nationally representative survey, we demonstrate that individuals still hold dual national and state identities, and that the likelihood that one will feel attached to their state depends on a variety of individual characteristics such as education, identification with a marginalized or minority community within the state, and one’s ideological “fit” with the partisan majority in their state, leading to significant variance from one citizen to the next. Additionally, we find that this state identity is correlated with political attitudes, particularly trust in and assessment of state elected officials. Individuals who hold stronger state identities are also more likely to trust their state government. These findings have implications for our understanding of the dynamics of federalism in modern U.S. politics.
Accumulation of Disadvantages Across Multiple Domains Amongst Subgroups of Children of Parents With Schizophrenia or Bipolar Disorder: Clustering Data from the Danish High Risk and Resilience Study VIA 7
Authors: Krantz Mette Falkenberg , Ellersgaard Ditte , Andersen Klaus Kaae , Hemager Nicoline , Christiani Camilla , Spang Katrine Søborg , Burton Birgitte Klee , Gregersen Maja , Søndergaard Anne , Greve Aja , Gantriis Ditte Lou , Ohland Jessica , Mortensen Preben Bo , Werge Thomas , Nudel Ron , Wang Yunpeng , Hougaard David M , Plessen Kerstin Jessica , Bliksted Vibeke , Jepsen Jens Richardt Møllegaard , Thorup Anne A E , Mors Ole , Nordentoft Merete 
Published: January 2022

AbstractObjectiveChildren with familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) are frequently affected in a range of domains known to be precursors of severe mental illness. No previous studies have gathered known precursors to examine whether they distribute evenly across familial high risk (FHR) children or if they cluster among a smaller group. Since such examination holds the potential to identify high and low risk of severe mental illness groups, we aimed to cluster FHR and control children affected to various degrees.MethodIn The Danish High Risk and Resilience Study VIA 7, a clinical cohort study, 514 7-year-old children with FHR-SZ or FHR-BP and matched controls were assessed in domains of motor function, neurocognition, emotional control, behavior, social cognition, self-perception, language, psychotic experiences, and psychopathology, and grouped using cluster analysis. Associations between clusters and parents' level of education, functioning, caregiver status, child's level of stimulation and support in the home, and polygenic risk scores were examined.ResultsA total of four groups including one of broadly affected children were identified. The broadly affected group was represented 4–5-fold (18.1%) amongst FHR-SZ children and 2–3-fold (10.2%) amongst FHR-BP children, compared to controls (4.1%) (P &lt; .001), and the broadly affected group had lower levels of caregiver functioning (P &lt; .001) and stimulation and support at home (P &lt; .001).ConclusionPrecursors of severe mental illness distribute unevenly among FHR children; while approximately half are not affected in any domains, the other half are affected to various degrees. Targeted support towards the affected groups is indicated.
Rates and Predictors of Disengagement and Strength of Engagement for People With a First Episode of Psychosis Using Early Intervention Services: A Systematic Review of Predictors and Meta-analysis of Disengagement Rates
Authors: Robson Elizabeth , Greenwood Kathryn 
Published: January 2022

AbstractDisengagement is a problem in early intervention for psychosis services; identifying predictors is important to maximise mental-health care.AimTo establish the average disengagement rate, time to disengage, and predictors of disengagement or strength of engagement.MethodsPapers were identified from 5 databases and citation searches; chosen if they reported dis/engagement in early intervention services, discarded if they didn't give a clear definition of disengagement. The studies were rated for quality and a systematic review identified predictors of engagement; meta-analysis established the average disengagement rate. Meta-regression evaluated associations between disengagement and year of study or length of follow up.Results26 papers were reviewed comprising over 6800 participants, meta-analysis of 15 eligible cohorts found that the average disengagement rate was 15.60% (95% confidence intervals 11.76%–20.45%), heterogeneity was considerable, important to note when reporting as a global average. Higher disengagement rates were associated with earlier studies and length of follow up; causal factors are unclear due to the lack of data and complex interaction between clinical and methodological issues. Robust predictors of disengagement were substance use, contact with the criminal justice system, medication non-adherence, and lower symptom severity.ConclusionsDisengagement rates have declined although the cause is not clear partly due to methodological variation, we suggest a guide for defining disengagement. Underpinning reasons for disengagement could include people who struggle to engage (substance users), don’t want to engage (medication non-adherence) or feel they don’t need to engage (lower symptomology). Future research should focus on minority status, education/employment during treatment, and digital technologies.
Maturity of white matter tracts is associated with episodic memory recall during development
Authors: Bouyeure Antoine , Bekha Dhaif , Patil Sandesh , Hertz-Pannier Lucie , Noulhiane Marion 
Published: January 2022

Abstract
The structure-function relationship between white matter microstructure and episodic memory (EM) has been poorly studied in the developing brain, particularly in early childhood. Previous studies in adolescents and adults have shown that episodic memory recall is associated with prefrontal-limbic white matter microstructure. It is unknown whether this association is also observed during early ontogeny. Here, we investigated the association between prefrontal-limbic tract microstructure and EM performance in a cross-sectional sample of children aged 4 to 12 years. We used a multivariate partial least squares correlation approach to extract tract-specific latent variables representing shared information between age and diffusion parameters describing tract microstructure. Individual projections onto these latent variables describe patterns of interindividual differences in tract maturation that can be interpreted as scores of white matter tract microstructural maturity. Using these estimates of microstructural maturity, we showed that maturity scores of the uncinate fasciculus and dorsal cingulum bundle correlated with distinct measures of EM recall. Furthermore, the association between tract maturity scores and EM recall was comparable between younger and older children. Our results provide new evidence on the relation between white matter maturity and EM performance during development.
Synergistic Effects of Bacillus amyloliquefaciens SDTB009 and Difenoconazole on Fusarium Wilt of Tomato
Authors: Xu Xueming , Wang Yongqiang , Lei Ting , Sohail Muhammad Aamir , Wang Jie , Wang Hongyan 
Published: January 2022

Fusarium wilt is a destructive and widespread disease of tomatoes in China, and currently, there are no effective and environmentally friendly control measures. Combining biological control agents with fungicides has become an executable method for disease control. Here, Bacillus amyloliquefaciens SDTB009 showed excellent in vitro antagonistic activity against Fusarium oxysporum and tolerance to high concentrations of difenoconazole (200 mg/liter) in vitro. The combination of SDTB009 and difenoconazole exhibited more effectiveness in mycelial growth inhibition than either treatment alone. Compared with that in the SDTB009 bulk solution in vitro (5.22 g/liter), surfactin titer reached 7.15 g/liter in the 100 mg/liter of difenoconazole-containing medium. Interestingly, the upregulation of 20 genes in the surfactin biosynthesis pathway from 2-fold to 4-fold was observed, explaining the synergistic effect. The SDTB009 combined with varying concentrations of difenoconazole (60, 120, and 150 g a.i./ha) showed a synergistic effect in two consecutive years of field trials. These results show that the integration of difenoconazole with the biocontrol agent B. amyloliquefaciens SDTB009 synergistically increases the control efficacy of the fungicide against tomato Fusarium wilt.
The long-term association between bilateral oophorectomy and depression: a prospective cohort study
Authors: Bräuner Elvira V. , Wilson Louise F. , Koch Trine , Christensen Jane , Dehlendorff Christian , Duun-Henriksen Anne Katrine , Priskorn Lærke , Abildgaard Julie , Simonsen Mette K. , Jørgensen Jeanette T. , Lim Youn-Hee , Andersen Zorana J. , Juul Anders , Hickey Martha 
Published: January 2022

Abstract

Objective:
Depression is a leading cause of disability globally and affects more women than men. Ovarian sex steroids are thought to modify depression risk in women and interventions such as bilateral oophorectomy that permanently change the sex steroid milieu may increase the risk of depression. This study aimed to investigate the associations between unilateral and bilateral oophorectomy and depression over a 25-year period (1993-2018) and whether this varied by age at oophorectomy or use of menopausal hormone therapy.

Methods:
Twenty-five thousand one hundred eighty-eight nurses aged ≥45 years from the Danish Nurse Cohort were included. Nurses with depression prior to baseline were excluded. Poisson regression models, with log-transformed person-years as offset, were used to assess the associations between oophorectomy and incident depression. Nurses who retained their ovaries were the reference group.

Results:
Compared with nurses with retained ovaries, bilateral oophorectomy was associated with a slightly higher rate of depression (rate ratio [RR], 1.08; 95% confidence interval [CI], 0.95-1.23), but without statistical significance. However, when stratified by age at oophorectomy, compared with nurses with retained ovaries, bilateral oophorectomy at age ≥51 years was associated with higher rates of depression (RR 1.16; 95% CI, 1.00-1.34), but not bilateral oophorectomy at age <51 years (RR 0.86; 95% CI, 0.69-1.07); P value for difference in estimates = 0.02. No association between unilateral oophorectomy and depression was observed.

Conclusions:
In this cohort of Danish female nurses, bilateral oophorectomy at age ≥51 years, but not at younger ages, was associated with a slightly higher rate of depression compared with those who retained their ovaries.
Assessment of International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) Code Assignment Validity for Case Finding of Medication-related Hypoglycemia Acute Care Visits Among Medicare Beneficiaries
Authors: Yang Tsu-Hsuan , Ziemba Robert , Shehab Nadine , Geller Andrew I. , Talreja Karan , Campbell Kyle N. , Budnitz Daniel S. 
Published: January 2022

Objective:
Administrative claims are commonly relied upon to identify hypoglycemia. We assessed validity of 14 International Classification of Diseases, Tenth Revision, Clinical Modification diagnosis code assignments to identify medication-related hypoglycemia leading to acute care encounters.

Research Design and Methods:
A multisite, retrospective medical record review study was conducted in a sample of Medicare beneficiaries prescribed outpatient diabetes medications and who received hospital care between January 1, 2016 and September 30, 2017. Diagnosis codes were validated with structured medical record review using prespecified criteria (clinical presentation, blood glucose values, and treatments for hypoglycemia). Sensitivity, specificity, and positive and negative predictive value (PPV, NPV) were calculated and adjusted using sampling weights to correct for partial verification bias.

Results:
Among 990 encounters (496 cases, 494 controls), hypoglycemia codes demonstrated moderate PPV (69.2%; 95% confidence interval: 65.0–73.0) and moderate sensitivity (83.9%; 95% confidence interval: 70.0–95.5). Codes performed better at identifying hypoglycemic events among emergency department/observation encounters compared with hospitalizations (PPV 92.9%, sensitivity 100.0% vs. PPV 53.7%, sensitivity 71.0%). Accuracy varied by diagnosis position, especially for hospitalizations, with PPV of 95.6% versus 46.5% with hypoglycemia in primary versus secondary positions. Use of adverse event/poisoning codes did not improve accuracy; reliance on these codes alone would have missed 97% of true hypoglycemic events.

Conclusions:
Accuracy of International Classification of Diseases, Tenth Revision codes in administrative claims to identify medication-related hypoglycemia varied substantially by encounter type and diagnosis position. Consideration should be given to the trade-off between PPV and sensitivity when selecting codes, encounter types, and diagnosis positions to identify hypoglycemia.
Next-Generation Sequencing Analysis in Posttransplant Relapsed Acute Myeloid Leukemia Reveals Clonal Evolution and Donor-Derived Germline Variant Indicating Bone Marrow Chimerism
Authors: Kroloff Maxwell J. , Crane Genevieve M. , Press Richard D. , Lee Stephen , Larson Sarah M. , Xian Rena R. 
Published: January 2022

Abstract
The era of next-generation sequencing (NGS) has led to a deeper understanding of the genetic complexity and heterogeneity of this disease, in addition to revealing mechanisms of disease relapse. Clinical NGS is becoming routine in clinical practice in both solid organ and hematologic malignancies to identify molecular markers of disease that might assist with diagnosis, prognosis, and the treatment of cancer. These tumor-specific markers also enable treatment response monitoring, as they serve as clonal markers unique to the disease. Continuous molecular monitoring also allows identification of disease recurrence with potentially new actionable mutations. This practice is complicated in the setting of allogeneic bone marrow transplant, as the admixtures of donor and recipient DNA pose unique challenges to NGS interpretation. This case highlights the importance of systematic methodological interpretation of NGS results to better understand the clinical significance and impact of new mutations discovered posttransplant and reveals another potential application of NGS for bone marrow engraftment analysis.