bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants in the adoption of a non-labor-substitution technology: mechanical ventilation in West Virginia coal mines, 1898–1907
Authors: Silvestre Javier , Murray John E. 
Published: November 2022

AbstractAccounts of technological change during industrialization processes based on labor-saving innovations are commonplace, even more so in the coal mining industry, in which the focus has until now been placed on the steam engine water pump and the coal cutting machine. However, to better understand technological change, we need to bear in mind the study of complementary capital. While previous research on complementary capital relies on evidence for manufacturing or the aggregate economy, this paper focuses on a case study, which provides more details on technology adoption decisions. This paper considers mechanical ventilation, a prominent and largely overlooked technology complementary to labor, as a response to stale air and explosions in the exploitation of coal. We examine the determinants in the adoption of the newer technology—the mechanical ventilator—through an economic model that is established at a high level of disaggregation: the mine. We concentrate on the West Virginia coalfield at the turn of the twentieth century, an apt historical setting for the study of technology adoption. We quantify characteristics of mines over time, so we are able to estimate a panel. We show the importance of various costs and benefits in explaining which type of mine converted from older technologies to the newer technology. The model is complemented with qualitative information, which helps to explain why an older technology slowed the process of adopting the newer as a result of different costs associated with the substitution.
Associations between patient-reported late effects and systemic cytokines in long-term survivors of head and neck cancer treated with radiotherapy
Authors: Huynh T. T. M. , Aass H. C. D. , Falk R. S. , Astrup G. L. , Helland Å. , Bjøro T. , Bjordal K. , Dale E. , Hellebust T. P. , Herlofson B. B. , Malinen E. , Kiserud C. E. , Osnes T. , Amdal C. D. 
Published: November 2022

Abstract
Purpose
Head and neck cancer (HNC) treatment may lead to late effects and impaired health-related quality of life of survivors. Knowledge on long-term late effects after radiotherapy (RT) and potential underlying biological mechanisms is lacking. We assessed the prevalence of xerostomia, dysphagia, and chronic fatigue (CF) in HNC survivors ≥ 5 years post-RT, and examined associations between pro-inflammatory cytokines and late effects.

Methods
In a cross-sectional study, 263 HNC survivors treated between 2007 and 2013 were enrolled. They completed validated questionnaires assessing xerostomia and dysphagia (the EORTC QLQ-H&N35), and CF (the Fatigue Questionnaire), and underwent blood sampling and clinical examination. Pro-inflammatory cytokines were analyzed in 262 survivors and 100 healthy age- and gender-matched controls.

Results
Median time since treatment was 8.5 years. The proportions of survivors reporting xerostomia, dysphagia, and CF were 58%, 31%, and 33%, respectively, with a preponderance of females. We found no significant associations between IL-6, IL-8, IP-10, TARC, TNF, or ENA-78 and the three late effects. The odds of having elevated levels of IL-6 and IP-10 were significantly higher in the survivors compared to the controls.

Conclusions
More than one-third of long-term HNC survivors experienced xerostomia, dysphagia, and CF. Persistent inflammation, with elevated systemic cytokines, was not associated with these late effects, although HNC survivors had higher levels of some cytokines than the controls.

Implications for Cancer Survivors
This study provides new knowledge on late effects that can serve as grounds for informing patients with HNC about risk of late effects more than 5 years after RT.
The Power of Birth Cohorts to Study Risk Factors for Cognitive Impairment
Authors: Richards Marcus 
Published: November 2022

Abstract
Purpose of Review
Birth cohorts are studies of people the same time; some of which have continuously followed participants across the life course. These are powerful designs for studying predictors of age-related outcomes, especially when information on predictors is collected before these outcomes are known. This article reviews recent findings from these cohorts for the outcomes of cognitive function, cognitive impairment, and risk of dementia, in relation to prior cognitive function, and social and biological predictors.

Recent Findings
Cognitive function and impairment are predicted by a wide range of factors, including childhood cognition, education, occupational status and complexity, and biological factors, including genetic and epigenetic. The particular importance of high and rising blood pressure in midlife is highlighted, with some insight into brain mechanisms involved. Some limitations are noted, including sources of bias in the data.

Summary
Despite these limitations, birth cohorts have provided valuable insights into factors across the life course associated with cognitive impairment.
Towards an integrated framework to measure user engagement with interactive or physical products
Authors: Castiblanco Jimenez Ivonne Angelica , Gomez Acevedo Juan Sebastian , Marcolin Federica , Vezzetti Enrico , Moos Sandro 
Published: November 2022

AbstractBuilding great products or services is not easy; users want products and services that exceed their expectations and evolve with their needs; it is not just about building the right features. Knowing the user engagement (UE) towards a physical, virtual product or service can give valuable information that could be used as feedback for the design, enhancing its chances of success. In the context of user-centered design, UE is the assessment of the user experience characterized by the study of the individual's cognitive, affective, and behavioral response to some stimulus, such as a product, a service, or a website. UE considers not only the users’ requirements and wishes but also their perceptions and reactions during and after an interaction with a product, system, or service. Many studies looking to quantify the UE are available. Still, a framework that provides a generic view of the most commonly used methods and metrics to measure UE does not yet exist in the literature. Aiming to understand the UE better, in this research, we developed a conceptual framework summarizing the available metrics and techniques used across different contexts, including good practices of self-report methods and physiological approaches. We expect this study will allow future researchers, developers, and designers to consider the UE as one of the most prominent product/service success indicators and use this guideline to find the more appropriate method, technique, and metric for its measurement.
TPEN/TPGS (T2) combo dramatically reduces Philadelphia chromosome-positive pro-lymphoblastic B leukemia in BALB/c mice
Authors: Mendivil-Perez Miguel , Jimenez-Del-Rio Marlene , Velez-Pardo Carlos 
Published: November 2022

AbstractAcute lymphoblastic leukemia (ALL) is hematological neoplasia that affects human beings from early life to adulthood. Although ALL treatment has been effective, an important percentage of ALL patients are resilient to treatment. Therefore, there is an urgent need for testing a new combination of compounds for the treatment of this disease. Recently, combined TPEN and TPGS (T2 combo) have shown selective cytotoxic effects in vitro leukemia cells such as Jurkat, K562, and Ba/F3 cells. In this study, we aimed to test the effect of combined TPEN and TPGS agents (T2 combo) at a fixed dose (TPEN 5 mg/kg: TPGS 100 mg/kg) on leukemic Ba/F3-BCR-ABL P210 BALB-c mice model. We found that 4 successive 2-day apart intravenous injections of T2 combo showed a statistically significant reduction of Ba/F3 BCR-ABL leukemia cells (− 69%) in leukemia BALB/c mice (n = 6) compared to untreated leukemia group (n = 6). Moreover, the T2 combo was innocuous to non-leukemia BALB/c mice (n = 3) compared to untreated non-leukemia mice (control, n = 3). After treatments (day 42), all mice were left to rest until day 50. Outstandingly, the leukemia BALB/c mice treated with the T2 combo showed a lower percentage of Ba/F3-BCR-ABL P210 cells (− 84%) than untreated leukemia BALB/c mice. Furthermore, treatment of leukemia and non-leukemia mice with T2 combo showed no significant tissue alteration/damage according to the histopathological analysis of brain, heart, liver, kidney, and spleen samples; however, T2 combo significantly reduced the number of leukocytes in the bone marrow of treated leukemia mice. We conclude that the T2 combo specifically affects leukemia cells but no other tissue/organs. Therefore, we anticipate that the T2 combo might be a potential pro-oxidant combination for the treatment of leukemia patients.
Meiotic nuclear divisions 1 promotes proliferation and metastasis in hepatocellular carcinoma and is a potential diagnostic and therapeutic target gene
Authors: Tan Kai , Wang Kunlei , Zhao Anbang , Liu Zhicheng , Song Wenjing , Cheng Qian , Li Xinyin , Chen Zhinan , Yuan Yufeng , Yang Zhiyong 
Published: November 2022

AbstractHepatocellular carcinoma is the cancer with the highest incidence among liver cancers and how to treat this cancer effectively is still a difficult problem we must face. We selected meiotic nuclear divisions 1 (MND1) as the study object by combining data from The Cancer Genome Atlas (TCGA) database with prognostic survival analysis. We validated the value of MND1 in evaluating the prognosis of hepatocellular carcinoma through a diagnostic and prognostic model. At the same time, cellular experiments were used to demonstrate the effect of MND1 on hepatocellular carcinoma proliferation and migration. We used short hairpin RNA (shRNA) to knock down MND1 in Hun7 and HCCLM3 cell lines. Through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and colony formation assays, we found that knocking down MND1 reduced the proliferation of cells. Through wound healing and Transwell assays, we found that knocking down MND1 reduced cell migration and invasion. Moreover, we found that MND1 can promote the proliferation, migration, and invasion of Hep3B cells by overexpressing MND1. Therefore, in general, MND1 is expected to be a gene that can effectively diagnose and treat hepatocellular carcinoma.
“You Look So Beautiful… But Why Are You So Distressed?”: The Negative Effects of Appearance Compliments on the Psychological Well-being of Individuals in the Workplace
Authors: Pacilli Maria Giuseppina , Spaccatini Federica , Roccato Michele 
Published: November 2022

AbstractThe primacy of beauty for women is frequently conveyed through language and, more particularly, through a particular class of conversational devices, compliments. Although previous research has been conducted on the impact of appearance compliments on individuals’ psychological state, research has yet to examine what happens when a compliment about the appearance clearly conveys a positive evaluation in a domain that is completely unrelated to the evaluation’s context, such as a selection interview for a job. Because the selection of a candidate should be based solely on their skills and competence, with no role for physical appearance, we purposely chose a job interview scenario to examine the psychological impact of inappropriate compliments. Through two 2-by-2 experimental studies (Ns respectively = 135 and 301), we examined whether and how anxiety and depression levels vary in women (Study 1 and Study 2) and men (Study 2) applicants who received compliments on their physical appearance, vs. their competence and had a neutral vs. positive feedback on the result of the interview. Findings of the two studies consistently showed that inappropriate compliments increase anxiety and depression levels in women but not in men, independently of the positive or neutral result of the selection interview. This research provides an important opportunity to advance the understanding of inappropriate appearance compliments on psychological well-being of the recipients in the workplace setting.
Explainable product backorder prediction exploiting CNN: Introducing explainable models in businesses
Authors: Shajalal Md , Boden Alexander , Stevens Gunnar 
Published: November 2022

AbstractDue to expected positive impacts on business, the application of artificial intelligence has been widely increased. The decision-making procedures of those models are often complex and not easily understandable to the company’s stakeholders, i.e. the people having to follow up on recommendations or try to understand automated decisions of a system. This opaqueness and black-box nature might hinder adoption, as users struggle to make sense and trust the predictions of AI models. Recent research on eXplainable Artificial Intelligence (XAI) focused mainly on explaining the models to AI experts with the purpose of debugging and improving the performance of the models. In this article, we explore how such systems could be made explainable to the stakeholders. For doing so, we propose a new convolutional neural network (CNN)-based explainable predictive model for product backorder prediction in inventory management. Backorders are orders that customers place for products that are currently not in stock. The company now takes the risk to produce or acquire the backordered products while in the meantime, customers can cancel their orders if that takes too long, leaving the company with unsold items in their inventory. Hence, for their strategic inventory management, companies need to make decisions based on assumptions. Our argument is that these tasks can be improved by offering explanations for AI recommendations. Hence, our research investigates how such explanations could be provided, employing Shapley additive explanations to explain the overall models’ priority in decision-making. Besides that, we introduce locally interpretable surrogate models that can explain any individual prediction of a model. The experimental results demonstrate effectiveness in predicting backorders in terms of standard evaluation metrics and outperform known related works with AUC 0.9489. Our approach demonstrates how current limitations of predictive technologies can be addressed in the business domain.
Fabrication of cellulose acetate/cellulose nitrate/carbon black nanofiber composite for oil spill treatment
Authors: Elmaghraby Nehad A. , Omer Ahmed M. , Kenawy El-Refaie , Gaber Mohamed , El Nemr Ahmed 
Published: November 2022

AbstractThere are global challenges in addressing the oil spill treatment. Nanofiber has become a great potential in the oil spill cleaning process because of the environmental friendliness, high efficiency, low cost, and stability of the obtained nanofiber mats. This study presents a novel composite fabricated from cellulose acetate (CA) and cellulose nitrate (CN) nanofibers with the incorporation of carbon black (CA-CN/CB) for efficient oil removal. This nanofiber composite was fabricated in one-step electrospinning of 10% CA and CN solution with different concentrations of carbon black (CB). The morphology and fiber diameter of the CA-CN/CB nanofiber composite were analyzed using scanning electron microscopy (SEM), and they appeared to be smooth, uniform fibers without beads. The average fiber diameter was in nano-meter size and increased with the increasing CB amount in the composite, ranging from 327 to 755 nm. The FTIR results indicated the presence of CA and CN as characteristic peaks of C = O for CA and O-NO2 for CN. The nanofibers mats of the CA-CN, CA-CN/CB0.7, CA-CN/CB1.5, and CA-CN/CB2.2 composites had Brunauer–Emmett–Teller (BET) surface area of 15.29, 38.40, 4.08, and 6.17 m2 g−1, respectively. Under optimal conditions, CA-CN/CB nanofiber mats absorb more than their weight oil in just 30 min. The adsorption result showed that loading 1.5% of CB to CA-CN mats (CA-CN/CB1.5) was more favorable for oil adsorption. The CA-CN/CB1.5 nanofiber showed its reusability for oil adsorption. The Freundlich isotherm model was the most appropriate model among other isotherm models, including Langmuir and Temkin, with a value of correlation coefficient (R2) equal to or closer to unity, and this result was confirmed by the data obtained from studying different error function models. The adsorption kinetics showed that oil adsorption into CA-CN/CB1.5 nanofiber follows a pseudo-second-order kinetics model with R2 close to unity.
Die psychische Gesundheit unserer Kinder und Jugendlichen und deren Behandlungsmöglichkeiten im Drei-Länder-Vergleich (Ö, D, CH) unter Berücksichtigung der Veränderungen durch die COVID-19-Pandemie
Authors: Sevecke Kathrin , Wenter Anna , Haid-Stecher Nina , Fuchs Martin , Böge Isabel 
Published: November 2022

Zusammenfassung
Hintergrund und Fragestellung
In einer von der Österreichischen Gesellschaft für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie (ÖGKJP) für die Neuropsychiatrie kuratierten Artikelserie erscheinen in einem Schwerpunktheft Arbeiten, die die kinder- und jugendpsychiatrische Versorgungslage zum Thema haben. Der vorliegende Artikel hat sich zum Ziel gesetzt, einen diesbezüglichen Drei-Länder-Vergleich zwischen Österreich, Deutschland und der Schweiz zu machen und Konklusionen für die österreichische kinder- und jugendpsychiatrische Versorgungslandschaft zu ziehen.

Methode
Zunächst werden epidemiologische Eckdaten sowie unterschiedliche Traditionen und Behandlungsphilosophien und deren Niederschlag im öffentlichen Gesundheitssystem der drei deutschsprachigen Länder Österreich, Deutschland und Schweiz vorgestellt. Im Anschluss werden die kinder- und jugendpsychiatrischen Versorgungsdaten von Österreich und Deutschland aufgezeigt und zueinander in Beziehung gestellt.

Ergebnisse und Schlussfolgerungen
In der österreichischen kinder- und jugendpsychiatrischen Versorgung besteht – wenn man die epidemiologische Datenlage, die deutliche Verschlechterung des psychischen Gesundheitszustandes der Kinder und Jugendlichen durch die Pandemie sowie die bisher niedrigen Bettenmessziffern (0,03–0,09) zugrunde legt – dringender Handlungsbedarf. Eine Verbesserung der strukturellen Defizite in der Forschungs- und Versorgungslandschaft, eine deutliche Erhöhung der Kapazitäten im stationären, teilstationären sowie ambulanten Bereich unter Berücksichtigung moderner Strukturen wie des Hometreatments, sind notwendig.
Uneindeutiges vereindeutigen
Authors: Kalwa Nina 
Published: November 2022

ZusammenfassungDie Praktik des Verortens kann als zentrale soziale Praktik betrachtet werden, durch die eine Person zeichenhaft ihre eigene Identität sowie eine bestimmte Wirklichkeit hervorbringt. Der Beitrag geht der Frage nach, wie sich Personen mit nicht-binärer Geschlechtsidentität verorten und welche sprachlichen Mittel sie dabei verwenden. Dazu werden mittels korpus- und textlinguistischer Methoden Beiträge von und an nicht-binäre(n) Personen analysiert.
Orbital Stability of Peakons and Multi-peakons for a Generalized Cubic–Quintic Camassa–Holm Type Equation
Authors: Deng Tongjie , Chen Aiyong 
Published: November 2022

AbstractThe peakons and mulit-peakons for a generalized cubic–quintic Camassa–Holm type equation have been obtained by Weng et al. (Monatsh Math, 2022. https://doi.org/10.1007/s00605-022-01699-w). In this paper, by constructing certain Lyapunov functionals, we prove that the peakons were orbitally stable in the energy space. Furthermore, using energy argument and combining the method of the orbital stability of peakons with monotonicity of the local energy norm, we also prove that the sum of N sufficiently decoupled peakons is orbitally stable in the energy space.
Research Ambassador Program: An innovative educational approach to addressing underrepresentation of minority populations in clinical research
Authors: Wolfe Nicole , Rubio-Diaz Mayra , Garcia Alma , Calderon Sara , Kipke Michele D. 
Published: November 2022

Abstract
Clinical trial participation among historically underrepresented populations remains low in large part due to mistrust of academic institutions and research investigators. Mistrust may be ever greater today given misinformation related to COVID-19. The Research Ambassador Program is an interactive educational workshop delivered by Promotoras de Salud/Community Health Workers and designed to both address common myths, fears, and concerns about research and encourage research participation among underrepresented populations. An evaluation conducted with 819 Latino and Black participants demonstrated a change in behavior and intention to participate in a clinical trial, with half of participants enrolling in a clinical trial research registry.
Structural racism in healthcare and research: A community-led model of curriculum development and implementation
Authors: Terrance Traci C. , Sugarwala Laura , McIntosh Scott , Bisbee-Burrows Mary , Castillejo Lucia , Evans Alicia , Reed Katie , Rogers Karen , Cullen John P. 
Published: November 2022

Abstract
Structural racism in the USA has roots that extend deep into healthcare and medical research, and it remains a key driver of illness and early death for Black, Indigenous, People of Color (BIPOC). Furthermore, the persistence of racism within academic medicine compels an interrogation of education and research within this context. In the spirit of this interrogation, this article highlights a unique model of community-engaged education that integrates cultural humility. As an individual and institutional stance, cultural humility denotes lifelong learning and self-critique, the mitigation of power imbalances, and accountability. The integration of cultural humility emphasizes that when space is created for BIPOC communities to lead the way, education regarding healthcare and research can be effectively reimagined. Demonstrating this effectiveness, six community partners led the development and implementation of a five-module Structural Racism in Healthcare and Research course. Using a cohort model approach, the pilot course enrolled 12 community members and 12 researchers. The curriculum covered topics such as history of racism in healthcare and research, and introduced participants to a cultural resilience framework. Evaluation results demonstrated a significant increase in participants’ knowledge and ability to identify and take action to address inequities related to racism in healthcare and research.