bluuebunny/crossref_metadata_2025_split huggingface dataset:
Small extracellular vesicles in metabolic remodeling of tumor cells: Cargos and translational application
Authors: Yang Hao , Wang Jingyi , Huang Gang 
Published: December 2022

Warburg effect is characterized by excessive consumption of glucose by the tumor cells under both aerobic and hypoxic conditions. This metabolic reprogramming allows the tumor cells to adapt to the unique microenvironment and proliferate rapidly, and also promotes tumor metastasis and therapy resistance. Metabolic reprogramming of tumor cells is driven by the aberrant expression and activity of metabolic enzymes, which results in the accumulation of oncometabolites, and the hyperactivation of intracellular growth signals. Recent studies suggest that tumor-associated metabolic remodeling also depends on intercellular communication within the tumor microenvironment (TME). Small extracellular vesicles (sEVs), also known as exosomes, are smaller than 200 nm in diameter and are formed by the fusion of multivesicular bodies with the plasma membrane. The sEVs are instrumental in transporting cargoes such as proteins, nucleic acids or metabolites between the tumor, stromal and immune cells of the TME, and are thus involved in reprogramming the glucose metabolism of recipient cells. In this review, we have summarized the biogenesis and functions of sEVs and metabolic cargos, and the mechanisms through they drive the Warburg effect. Furthermore, the potential applications of targeting sEV-mediated metabolic pathways in tumor liquid biopsy, imaging diagnosis and drug development have also been discussed.
The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trial
Authors: Cheong Pui Kuan , Ho Tin Muk , Chan Kam Leung , Lo Cho Wing , Leung Sin Bond , Hon Kam Lun , Leung Ka Chun , Siu Tony Hon Chung , Song Tian-He , Zhang Hongwei , Ching Jessica Yuet Ling , Chow Tak Yee , Sum Chi Him , Chia Chon Pin , Lin Zhi-Xiu 
Published: December 2022

Background: Allergic rhinitis (AR) is an upper airways chronic inflammatory disease mediated by IgE, which affects 10%–20% of the population. The mainstay for allergic rhinitis nowadays include steroids and antihistamines, but their effects are less than ideal. Many patients therefore seek Chinese medicine for treatment and Yupingfeng Powder is one of the most common formulae prescribed. In this study, we aim to investigate the efficacy and safety of Yupingfeng Powder with variation for the treatment of allergic rhinitis.Study design: This is a double-blind, randomized, placebo-controlled trial. A 2-week screening period will be implemented, and then eligible subjects with allergic rhinitis will receive interventions of either “Yupingfeng Powder with variation” granules or placebo granules for 8 weeks, followed by post treatment visits at weeks 12 and 16. The change in the Total Nasal Symptom Score (TNSS) will be used as the primary outcome.Discussion: This trail will evaluate the efficacy and safety of Yupingfeng Powder in treating allergic rhinitis. The study may provide the solid evidence of Yupingfeng Powder with variation can produce better clinical efficacy than the placebo granules.Trial registration:ClinicalTrials.gov, identifier NCT04976023.
Gene expression and DNA methylation altering lead to the high oil content in wild allotetraploid peanut (A. monticola)
Authors: Liu Nian , Wu Bei , Pandey Manish K. , Huang Li , Luo Huaiyong , Chen Yuning , Zhou Xiaojing , Chen Weigang , Huai Dongxin , Yu Bolun , Chen Hao , Guo Jianbin , Lei Yong , Liao Boshou , Varshney Rajeev K. , Jiang Huifang 
Published: December 2022

IntroductionThe wild allotetraploid peanut Arachis monticola contains a higher oil content than the cultivated allotetraploid Arachis hypogaea. Besides the fact that increasing oil content is the most important peanut breeding objective, a proper understanding of its molecular mechanism controlling oil accumulation is still lacking.MethodsWe investigated this aspect by performing comparative transcriptomics from developing seeds between three wild and five cultivated peanut varieties.ResultsThe analyses not only showed species-specific grouping transcriptional profiles but also detected two gene clusters with divergent expression patterns between two species enriched in lipid metabolism. Further analysis revealed that expression alteration of lipid metabolic genes with co-expressed transcription factors in wild peanut led to enhanced activity of oil biogenesis and retarded the rate of lipid degradation. In addition, bisulfite sequencing was conducted to characterize the variation of DNA methylation between wild allotetraploid (245, WH 10025) and cultivated allotetraploid (Z16, Zhh 7720) genotypes. CG and CHG context methylation was found to antagonistically correlate with gene expression during seed development. Differentially methylated region analysis and transgenic assay further illustrated that variations of DNA methylation between wild and cultivated peanuts could affect the oil content via altering the expression of peroxisomal acyl transporter protein (Araip.H6S1B).DiscussionFrom the results, we deduced that DNA methylation may negatively regulate lipid metabolic genes and transcription factors to subtly affect oil accumulation divergence between wild and cultivated peanuts. Our work provided the first glimpse on the regulatory mechanism of gene expression altering for oil accumulation in wild peanut and gene resources for future breeding applications.
Demographic and work-related factors associated with burnout, resilience, and quality of life among healthcare workers during the COVID-19 pandemic: A cross sectional study from Malaysia
Authors: Marzo Roy Rillera , ElSherif Mohamed , Abdullah Muhd Siv Azhar Merican Bin , Thew Hui Zhu , Chong Collins , Soh Shean Yih , Siau Ching Sin , Chauhan Shekhar , Lin Yulan 
Published: December 2022

IntroductionThe healthcare setting is a stressful and demanding work environment, and healthcare workers face a continuous expansion of their job roles and responsibilities. Past studies have shown that factors affecting burnout, resilience, and quality of life among healthcare workers merit further research, as there were inconsistent findings, especially with regards to the influence of demographic and work-related factors. Therefore, this study aims to determine whether demographic and work-related factors are associated with burnout, resilience, and quality of life among healthcare workers.MethodThis cross-sectional study was conducted between February 15, 2022 and March 15, 2022, among 394 healthcare workers from Putrajaya and Selangor hospitals, Malaysia. Maslach Burnout Inventory, World Health Organization Quality of Life-BREF 26 inventory, and Brief Resilience Scale were utilized to capture information on burnout, quality of life, and resilience, respectively.ResultsThe mean score of physical health of participants who work more than 10 h (11.38) is lower than participants who work from 8 to 10 h (13.00) and participants who work 7 h daily (13.03), p-value &lt; 0.001. Similarly, the mean score of psychological health of participants who work more than 10 h (12.35) is lower than participants who work from 8 to 10 h (13.72) and participants who work 7 h daily (13.68), p-value = 0.001. Higher income levels were associated with high resilience and quality of life.ConclusionIt is imperative that healthcare practitioners and policy makers adopt and implement interventions to promote a healthy workplace environment, address ethical concerns, and prevent burnout among healthcare workers during the COVID-19 pandemic. Managing the issue of long working hours could possibly result in improved resilience, burnout, and quality of life among healthcare workers. Despite this study able to tickle out some policy specific areas where interventions are needed, identifying effective solutions and evaluating their efficiency will require larger and interventional studies.
Will personality traits affect the use of e-cigar among college students? A cross-sectional study in Guangdong Province, China
Authors: Mai Jianrong , Lin Lina , Zhou Ling , Guan Qinyi , Zhu Wenhui , Zhou Wenzan 
Published: December 2022

BackgroundThe prevalence of e-cigar among adolescents and young adults around the world is increasing rapidly, which has a serious impact on the health of young people. This study assessed the prevalence of e-cigar among college students and to explore the relationship between e-cigar use and personality traits.MethodsThis study conducted an electronic questionnaire survey on college students who were from three undergraduate universities and three junior colleges in Guangdong Province from January 2022 to March 2022. The survey was conducted by stratified cluster sampling, and the respondents were 1362. Statistical descriptions are used to describe the demographic characteristics and personality traits of participants. Mann-Whitney U tests, and Chi-square tests were used to compare the differences between current e-cigar users and non e-cigar users. Two-step hierarchical Logistic regression was used to predict the associated factors with e-cigar use.ResultsThe prevalence of current e-cigar users was 5.1%. Agreeableness showed statistically significant higher in non-users (Z = 2.585, P &lt; 0.01). Moreover, gender (AOR = 0.312, 95%CI: 0.174–0.562), the relationship with mother (AOR = 5.887, 95%CI: 1.460–23.748), friends who use e-cigar (AOR = 3.808, 95%CI: 2.159–6.719), allowance per month (AOR = 2.482, 95%CI: 1.371–4.490), and agreeableness (AOR = 0.957, 95%CI: 0.918–0.997) were related to the use of e-cigar.ConclusionThe level of agreeableness is associated with the use of e-cigar among college students. All these provided an important theoretical basis for future intervention.
Incidence and determinants of hysterectomy among North Indian women: An 8-year follow-up study
Authors: Rajkumari Sunanda , Chaudhary Vineet , Kasaudhan Sapana , Saraswathy Kallur Nava 
Published: December 2022

BackgroundDespite indications of a rapid increase in the number of hysterectomies performed in India, very few studies have methodically investigated the rate and determinants of the incidence of hysterectomy. The present study aims to estimate the rate of incidence of hysterectomy and identify predictors/determinants of incident hysterectomy in a cohort of North Indian women.MethodsIn the present study, a cohort of 1,009 ever-married North Indian women (aged 30–75 years) was followed up after a median of 8.11 years. Those hysterectomized at the baseline (63) were excluded; and of the rest 946 participants, 702 (74.2%) could be successfully followed-up. During the baseline assessment, data about sociodemographic variables, reproductive history, menopausal status, physiological health, and selected blood biochemicals were collected. During the end-line assessment, data about sociodemographic variables, current menopausal status, and incident hysterectomy were recorded.ResultsThe overall rate of incidence of hysterectomy was found to be 11.59 per 1,000 women-years, in the study population. Interestingly, the incidence rates were found to be similar among pre- and post-menopausal women. Further, while late age at menarche was found to be negatively associated with incident hysterectomy, folate repletion and high triglyceride (TG) at the baseline were found to be positively associated.ConclusionsHigh rate of incident hysterectomy in the studied population points toward the huge burden of gynecological morbidity and the unavailability of non-invasive protocols. Such a situation warrants immediate policy intervention. Further, maintaining TG and folate within normal physiological ranges may be beneficial in gynecological ailments necessitating hysterectomy.
Musculoskeletal disorders among secondary school teachers in Douala, Cameroon: The effect of the practice of physical activities
Authors: Mekoulou Ndongo Jerson , Bika Lele Elysée Claude , Guessogo Wiliam Richard , Meche Laurence Patricia , Ayina Ayina Clarisse Noel , Guyot Jessica , Zengue Babette , Lobe Tanga Marie Yvonne , Owana Manga Léon Jules , Temfemo Abdou , Barth Nathalie , Bongue Bienvenu , Mandengue Samuel Honoré , Assomo Ndemba Peguy Brice 
Published: December 2022

IntroductionMusculoskeletal disorders (MSDs) represent an important threat to public health in both developed and developing countries, and are present in many occupational sectors including education. Regular practice of physical activity (PA) is known elicit preventive effects on the occurrence of MSDs.ObjectiveThis study aimed at determining the prevalence of MSDs and the preventive impact of PA on their occurrence among secondary school teachers.Participants and MethodsA cross-sectional study was conducted among 179 teachers in five government secondary schools in Douala, Cameroon. The Nordic and Ricci-Gagnon questionnaires were used to determine MSDs and to assess the level of PA, respectively.ResultsThe 12-month and 7-day prevalence of MSD (PMSD-12m and PMSD-7d) were 84.3% and 69.3%, respectively. The most affected body regions by MSDs were neck (PMSD-12m = 54.2%, PMSD-7d = 33.5%), lower back (PMSD-12m = 43%, PMSD-7d = 33%), and shoulders (PMSD-12m = 35%, PMSD-7d = 22.9%). Compared to female, males were protected against MSDs during the last 12 months (OR = 0.37; 95% CI 0.16–0.93; p = 0.04). The risk of MSDs during the last seven days was higher in teachers aged 30-40 years (OR = 2.86; 95% CI 1.14–7.14; p = 0.02) and 40-50 years (OR = 4.28; 95% CI 1.49–16.29; p = 0.008) than those under 30 years. This risk was tripled in inactive teachers (OR = 3.07; 95% CI 1.40–6.78; p = 0.005), compared to their active counterparts.ConclusionMSDs are prevalent among secondary school teachers and associated with aging, gender, and lower level of PA
Co-designing resources to support the transition from child to adult health services for young people with cerebral palsy: A design thinking approach
Authors: Fortune Jennifer , Burke Jessica , Dillon Conor , Dillon Sally , O’Toole Sharon , Enright Ann , Flynn Annmarie , Manikandan Manjula , Kroll Thilo , Lavelle Grace , Ryan Jennifer M. 
Published: December 2022

IntroductionDesign thinking is a human-centred process that aims to identify the needs of end-users and iteratively develop solutions. Involving end-users in the development and design of solutions may enhance effectiveness by increasing focus on the needs of the target population. This paper describes the process of co-designing resources to support the transition from child-centred to adult-orientated health services using a design thinking approach.MethodsFive co-design workshops were conducted remotely with a young person advisory group and parent advisory group. A design thinking process guided by the Stanford D.School approach was used to understand the transition needs of young people and their parents and iteratively develop solutions to improve end-user experience.ResultsEight resource prototypes were generated: (1) designated transition coordinator, (2) digital stories of transition experience (3) written informational support (4) transition website, (5) transition checklists and worksheets (6) transition app, (7) transition programme or course and (8) educational programme for health professionals.ConclusionDesign thinking is a feasible approach to identify, characterise and prioritise resources collaboratively with end-user partners.
A CMOS Voltage Reference with Output Voltage Doubling Using Modified 2T Topology
Authors: Li Junyao , Chan Pak Kwong 
Published: December 2022

This paper presents an ultra-low power CMOS voltage reference which operates in the subthreshold region. Modified from the conventional 2T circuit, the proposed circuit is capable of generating higher output voltage by using the resistor subdivision. The design comprises a negative-threshold native NMOS transistor as the current generator, a high-threshold PMOS transistor as the active load and an active voltage doubling network to generate the reference voltage. Implemented in TSMC 40 nm CMOS technology, the proposed circuit operates at a minimum supply of 0.65 V and consumes 5.5 nA. Under one sample simulation, the obtained T.C. is 16.64 ppm/°C and the nominal Vref is 489.6 mV (75.3% of Vddmin) for the temperature range from −20 °C to 80 °C. For Monte-Carlo simulation of 200 samples at room temperature, the average output voltage is 488 mV and the average T.C. is 29.6 ppm/°C whilst with the standard deviation of 13.26 ppm/°C. Finally, at room temperature, the proposed voltage reference has achieved a process sensitivity (σ/μ) of 3.9%, a line sensitivity of 0.51%/V and a power supply rejection of −45.5 dB and −76.3 dB at 100 kHz and 100 MHz. Compared to the representative prior-art works realized in the same technology and a similar supply current, the proposed circuit has offered the best 1-sampe T.C., the best average T.C. in multiple samples, the highest output voltage, the maximum output voltage per minimum supply voltage and the lowest process sensitivity in the output, Vref.
Process and Eco-Environment Impact of Land Use Function Transition under the Perspective of “Production-Living-Ecological” Spaces—Case of Haikou City, China
Authors: Du Wenxing , Wang Yuxia , Qian Dingyi , Lyu Xiao 
Published: December 2022

Land use function transition can change the eco-environment. To achieve an “Intensive and efficient production space, moderately livable living space, and beautiful ecological space”, the ecological effects of land use function transition in the context of ecologically fragile areas and rapidly developing areas of socio-economic importance need to be studied. In this study, from the perspective of “production-living-ecological” spaces, we calculated the index of regional eco-environment quality, positive and negative effects of eco-environment impact, and the ecological contribution rate and analyzed the driving factors. We found the following: (1) The production space was greatly compressed, living space was expanded, and ecological space was significantly squeezed. Haikou underwent a rapid transformation from an agriculture-dependent city to an industrial city. Land supply for urban and rural living was guaranteed by the Chinese land management department. However, Haikou prioritized economic development over environmental protection. (2) The regional eco-environment quality index decreased from 2009 to 2018. The expansion of pasture-based ecological spaces is important for improving the quality of the eco-environment, and the reduction of forest ecological space strongly influences the deterioration of the eco-environment. (3) Resource base, historical level of utilization, suitability of land, the ecological value potentiality, and regional policies greatly affected land use function transition and its eco-environment. (4) Refining the planning of territorial space, comprehensively improving land and resources, and reforming the rural land system greatly influenced policy guidance and technical regulation for coordinating “production-living-ecological” spaces and improving the regional eco-environment. In this study, we tested the effect of regional policy regulation on land use function transition and provided a reference for coordinating “production-living-ecological” spaces.
Les jeunes, l'islam et les pratiques culturelles. De l'indignité culturelle à la relégation institutionnelle
Authors: Césari Jocelyne , Moore Damian 
Published: December 2022

L'analyse des pratiques culturelles des jeunes de culture musulmane vivant dans les quartiers défavorisés en France peut être entreprise à partir de la notion d'indignité culturelle. En effet, ces derniers, en tant que musulmans, subissent la méfiance et le rejet au quotidien qui se doublent, dans le cas de leur engagement associatif, d'une relégation institutionnelle.
Afin d'appréhender cette notion d'indignité culturelle, on propose d'explorer des logiques culturelles caractéristiques du milieu maghrébin, dont celle de l'honneur notamment. Cet ethos de l'honneur, entre autres, a une influence sur les pratiques culturelles des jeunes issus de l'immigration maghrébine vivant dans les banlieues populaires. De plus, une observation des interactions quotidiennes entre des porteurs de projets culturels d'ethnicité maghrébine et des représentants des pouvoirs publics en charge de la politique de la ville dans le quartier Saint-Mauront, à Marseille, fait émerger la notion de relégation institutionnelle.
Jeunes en cité. Diversité des trajectoires ou destin commun ?
Authors: Marlière Éric 
Published: December 2022

Les transformations qui affectent nos sociétés ont de lourdes conséquences sur les ouvriers des banlieues, souvent immigrés, et plus encore sur leurs enfants : évoluant dans une société hostile, ceux-ci développent de multiples stratégies face à un avenir incertain.
Entre la poursuite d'études universitaires, l'investissement dans un emploi, l'attrait pour l'argent facile ou une situation d'attente et de galère, ces jeunes connaissent des trajectoires hétérogènes marquées par des rapports sociaux fragmentés. Ils déploient également des pratiques culturelles et des modes de vie qui leur sont propres, au carrefour d'un héritage familial, d'un islam urbain et individuel, de vestiges des cultures ouvrières et d'une adhésion aux valeurs marchandes véhiculées par les médias.
A travers une étude ethnographique, réalisée dans une cité HLM d'une ancienne «banlieue rouge», ce livre montre que le discours commun sur ces jeunes ne résiste pas à la pluralité des enjeux sociaux, ni à la complexité des situations. Il atteste aussi qu'une page de l'histoire ouvrière se tourne définitivement.
Cuisiner le passé. Souvenirs et pratiques culinaires des exilés pieds-noirs
Authors: Tabois Stéphanie 
Published: December 2022

■ Stéphanie Tabois
Cucinare il passato. Ricordi e pratiche culinarie degli esuli «Pieds-noirs»
Le pratiche culinarie dei «Pieds-noirs» dimostrano le trasformazioni identitarie all'interno di una comunità in diaspora. L'alimentare serve oggi ad omologare l'immagine data dal gruppo stesso per stabilire la sua memoria. Così è messa in luce la complessità della sua storia mediante i suoi modi di definizione mentre descrive lo spazio delle relazioni dei propri membri.
S'associer pour se souvenir. Le travail de mémoire des associations de migrants marocains en France
Authors: Dumont Antoine 
Published: December 2022

■ Dumont
To Get Together to Remember : The Memorial Endeavour of Moroccan Migrants Associations in France
After a century of Moroccan migration to France, associations that originated from it initiate a collective memory endeavour. If the most militant linked to the opposition to the King Hassan II (1961-1969) recall past struggles in order to act in our present-day, other fields of action emerge related to development and culture. But the immensity of the task, combined to poor resources and State strategy, is still a hindrance to remembrance.
Revenir au bled. Tourisme diasporique, généalogique, ethnique ou identitaire ?
Authors: Bidet Jennifer 
Published: December 2022

Return to the Algerian village : what type of tourism -diaspora , genealogical, tribal or the search for identity ?
It is possible to acquire an understanding of the production and reproduction of diasporas through the study of tourist practices of individuals -this emerges in the apparently paradoxical combination of short-term pleasure trips -tourism -and «enforced» long-term migrations
-diasporas. This article, based on PhD research, intends to develop this problematic through an examination of the social meanings of vacation «returns» among the Algerian diaspora. Starting with a bibliographical review of the studies connecting tourism and diasporas, this case study will seek to show the non-homogeneity of diaspora tourism. The notion of homogeneity is challenged by the present analysis of the changes in the vacation return patterns of several generations.