bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards guided and automated programming of subthalamic area stimulation in Parkinson’s disease
Authors: Xu San San , Sinclair Nicholas C. , Bulluss Kristian J. , Perera Thushara , Lee Wee-Lih , McDermott Hugh J. , Thevathasan Wesley 
Published: January 2022

AbstractSelecting the ideal contact to apply subthalamic nucleus deep brain stimulation in Parkinson’s disease can be an arduous process, with outcomes highly dependent on clinician expertise. This study aims to assess whether neuronal signals recorded intraoperatively in awake patients, and the anatomical location of contacts, can assist programming. In a cohort of 14 patients with Parkinson’s disease, implanted with subthalamic nucleus deep brain stimulation, the four contacts on each lead in the 28 hemispheres were ranked according to proximity to a nominated ideal anatomical location and power of the following neuronal signals: evoked resonant neural activity, beta oscillations and high-frequency oscillations. We assessed how these rankings predicted, on each lead: (i) the motor benefit from deep brain stimulation applied through each contact and (ii) the ‘ideal’ contact to apply deep brain stimulation. The ranking of contacts according to each factor predicted motor benefit from subthalamic nucleus deep brain stimulation, as follows: evoked resonant neural activity; r2 = 0.50, Akaike information criterion 1039.9, beta; r2 = 0.50, Akaike information criterion 1041.6, high-frequency oscillations; r2 = 0.44, Akaike information criterion 1057.2 and anatomy; r2 = 0.49, Akaike information criterion 1048.0. Combining evoked resonant neural activity, beta and high-frequency oscillations ranking data yielded the strongest predictive model (r2 = 0.61, Akaike information criterion 1021.5). The ‘ideal’ contact (yielding maximal benefit) was ranked first according to each factor in the following proportion of hemispheres; evoked resonant neural activity 18/28, beta 17/28, anatomy 16/28, high-frequency oscillations 7/28. Across hemispheres, the maximal available deep brain stimulation benefit did not differ from that yielded by contacts chosen by clinicians for chronic therapy or contacts ranked first according to evoked resonant neural activity. Evoked resonant neural activity, beta oscillations and anatomy similarly predicted how motor benefit from subthalamic nucleus deep brain stimulation varied across contacts on each lead. This could assist programming by providing a probability ranking of contacts akin to a ‘monopolar survey’. However, these factors identified the ‘ideal’ contact in only a proportion of hemispheres. More advanced signal processing and anatomical techniques may be needed for the full automation of contact selection.
Stopping versus continuing renin–angiotensin–system inhibitors after acute kidney injury and adverse clinical outcomes: an observational study from routine care data
Authors: Janse Roemer J , Fu Edouard L , Clase Catherine M , Tomlinson Laurie , Lindholm Bengt , van Diepen Merel , Dekker Friedo W , Carrero Juan-Jesus 
Published: January 2022

ABSTRACTBackgroundThe risk–benefit ratio of continuing with renin–angiotensin system inhibitors (RASi) after an episode of acute kidney injury (AKI) is unclear. While stopping RASi may prevent recurrent AKI or hyperkalaemia, it may deprive patients of the cardiovascular benefits of using RASi.MethodsWe analysed outcomes of long-term RASi users experiencing AKI (stage 2 or 3, or clinically coded) during hospitalization in Stockholm and Sweden during 2007–18. We compared stopping RASi within 3 months after discharge with continuing RASi. The primary study outcome was the composite of all-cause mortality, myocardial infarction (MI) and stroke. Recurrent AKI was our secondary outcome and we considered hyperkalaemia as a positive control outcome. Propensity score overlap weighted Cox models were used to estimate hazard ratios (HRs), balancing 75 confounders. Weighted absolute risk differences (ARDs) were also determined.ResultsWe included 10 165 individuals, of whom 4429 stopped and 5736 continued RASi, with a median follow-up of 2.3 years. The median age was 78 years; 45% were women and median kidney function before the index episode of AKI was 55 mL/min/1.73 m2. After weighting, those who stopped had an increased risk [HR, 95% confidence interval (CI)] of the composite of death, MI and stroke [1.13, 1.07–1.19; ARD 3.7, 95% CI 2.6–4.8] compared with those who continued, a similar risk of recurrent AKI (0.94, 0.84–1.05) and a decreased risk of hyperkalaemia (0.79, 0.71–0.88).DiscussionStopping RASi use among survivors of moderate-to-severe AKI was associated with a similar risk of recurrent AKI, but higher risk of the composite of death, MI and stroke.
The role of schools in transmission of the SARS-CoV-2 virus: quasi-experimental evidence from Germany
Authors: von Bismarck-Osten Clara , Borusyak Kirill , Schönberg Uta 
Published: January 2022

Abstract
This paper considers the role of school closures in the spread of the SARS-CoV-2 virus. To isolate the impact of the closures from other containment measures and identify a causal effect, we exploit variation in the start and end dates of the summer and fall school holidays across the 16 federal states in Germany using a difference-in-differences design with staggered adoption. We show that neither the summer closures nor the closures in the fall had a significant containing effect on the spread of SARS-CoV-2 among children or a spill-over effect on older generations. There is also no evidence that the return to school at full capacity after the summer holidays increased infections among children or adults. Instead, we find that the number of children infected increased during the last weeks of the summer holiday and decreased in the first weeks after schools reopened, a pattern we attribute to travel returnees.
Are we underestimating the impact of COVID-19 on children’s physical activity in Europe?—a study of 24 302 children
Authors: Kovacs Viktoria A , Brandes Mirko , Suesse Thomas , Blagus Rok , Whiting Stephen , Wickramasinghe Kremlin , Okely Anthony D 
Published: January 2022

Abstract
This repeat cross-sectional study investigated the impact of lockdown in Europe in Winter (January and February 2021) on children’s and adolescent’s physical activity (PA) and recreational screen time (RST), and compared PA to the lockdown in Spring 2020. An online survey was administered (n = 24 302; 6–18 years; 51.7% boys) in nine countries. PA and RST were assessed by 7-day recall. In total, 9.3% of children (95% confidence interval: 6.9–11.7) met WHO PA recommendation, which was half of the proportion observed in Spring 2020 [19.0% (18.2–19.9)]. Sixty percent exceeded the RST recommendations. This suggests that winter lockdown could have a more negative impact on PA than in spring.
The Draft Convention on the Right to Development: A New Dawn to the Recognition of the Right to Development as a Human Right?
Authors: Teshome Roman Girma 
Published: January 2022

Abstract
The draft Convention on the Right to Development is being negotiated under the auspices of the Human Rights Council. This article seeks to explore the merits and the added value of the draft in terms of its normative contents particularly compared with its soft law predecessor—the Declaration on the Right to Development. It argues that the draft is a momentous step in the recognition of the right to development as a human right not only because it is binding, if adopted, but also contains concrete, detailed and implementable norms. While it maintained the abstract and aspirational formulation of norms under the Declaration to a certain extent, the draft also addresses some of the prevailing gaps and limitations of the Declaration.
Stability implications of repackaged medications in dose administration aids: a systematic review
Authors: Lim Chiao Xin , Aliakbari Mozghan , Gokulanathan Vithiya R , Noah Sadeem , Taskin Rabia , Stupans Ieva , Allahham Ayman 
Published: January 2022

Abstract

Background
Dose administration aids (DAAs) or multi-compartment compliance aids are commonly used to organise doses of medications in accordance with a patient’s dosing schedule. Despite their widespread use, there is a paucity of information on the stability of repackaged medications in DAAs.

Objectives
The objectives of this work were to evaluate stability studies conducted on repackaged medicine in DAAs and to provide a summary of the latest stability data available.

Methods
A systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was performed on studies associated with repackaged medications in DAAs and drug stability. PubMed, CINAHL, EMBASE and SCOPUS were searched from January 1998 to June 2021.

Key findings
A total of 342 articles were retrieved and 29 articles met the inclusion criteria. Data regarding medications from the reviewed papers were reported according to stability testing and physicochemical properties. The extracted data were then compared with stability information on DAA provision available on the database in the UK. This review identified several discrepancies between this dataset and reported stability and reveals a significant shortage in the stability data of medications repackaged in DAAs.

Conclusion
This review highlights the need for further studies to be conducted to better understand the impact of DAA repackaging on the stability, safety and efficacy of medications. It is recommended that a database of stability information of repackaged medications via systematic stability testing studies could be established, serving as a valuable resource for pharmacists when preparing DAAs without compromising patient safety.
When the State Shatters Families. The US Family Separation Policy of 2018, Cruelty and Patrimonial Sovereignty
Authors: Goetze Catherine 
Published: January 2022

AbstractIn 2018, the Trump administration separated thousands of families arriving at the US–Mexico border to ask for asylum in the framework of its “zero-tolerance” policy. This extraordinary act of cruelty violated several provisions of international human rights, refugee, and family protections, many of which the United States itself had drafted, initiated, and championed. The article asks about the understanding of sovereignty that underscored the zero-tolerance policy. Drawing on Max Weber's distinction of several forms of legitimating political authority, the article develops the argument that this policy reflects a patrimonial understanding of sovereignty and how this understanding intersects with notions of family and nation. It specifically discusses these intersections in the case of United States’ sovereignty developing in a settler colonial state and in contested borderlands. By developing this perspective, the article draws out the conditions of possibility under which institutional and structural violence can tip into explicitly cruel policies like those of the US family separations of 2018. The article contributes, on the one hand, to analyze deeply the foundations of US understandings of the state's sovereignty and, on the other hand, to better comprehending which types of sovereignty enable cruelty against migrants and refugees at which points in time.
Branched ubiquitin code: from basic biology to targeted protein degradation
Authors: Ohtake Fumiaki 
Published: January 2022

Abstract
Protein ubiquitylation regulates numerous pathways, and the diverse information encoded by various forms of ubiquitylation is known as the ubiquitin code. Recent studies revealed that branched ubiquitin chains are abundant in mammalian cells and regulate important pathways. They include proteasomal degradation of misfolded and disease-causing proteins, regulation of NF-κB signalling and apoptotic cell fate decisions. Targeted protein degradation through chemical degraders emerged as a transformative therapeutic paradigm aimed at inducing the disappearance of unwanted cellular proteins. To further improve the efficacy of target degradation and expand its applications, understanding the molecular mechanism of degraders’ action from the view of ubiquitin code biology is required. In this review, I discuss the roles of the ubiquitin code in biological pathways and in chemically induced targeted protein degradation by focusing on the branched ubiquitin codes that we have characterized.
Shifts in chemical and microbiological properties belowground of invader Ageratina adenophora along an altitudinal gradient
Authors: Li Wei-Tao , Zheng Yu-Long , Wang Rui-Fang , Wang Zheng-Ying , Liu Yan-Mei , Shi Xiong , Liao Zhi-Yong , Li Yang-Ping , Feng Yu-Long 
Published: January 2022

Abstract
Tropical mountain ecosystems are usually colonized by numerous invasive plant species and represent an ideal ‘natural laboratory’ to study the effects of altitude on plant invasion. The aim of this study was to investigate the soil chemical and microbiological properties along an altitudinal gradient on a mountain colonized by the invader Ageratina adenophora. Rhizosphere soil of A. adenophora was collected over an altitudinal gradient (1400–2400 m) in Ailao Shan, China. We determined soil organic carbon (C), nutrient contents, enzyme activities, bacterial community composition as well as C and nitrogen (N) contents of the plant roots. Ecoenzymatic stoichiometric indices were calculated to estimate the relative C, N or P limitations of the microbial community. There was a significant effect of altitude on soil organic C in the rhizosphere, and a turning point in these measured variables was detected at an altitude of 2000 m. At low elevations, the rapid growth of invasive plants depleted the deficient phosphorus (P) in tropical soils, leading to microbial P limitation; at high elevations, microbes invested more energy to obtain C from resistant litter, leading to microbial C limitation. Bacterial beta diversity and soil pH contributed most to the altitudinal differences in ecoenzymatic stoichiometry, and Proteobacteria and Acidobacteria were the dominant bacterial phyla that determined the nutrient uptake status of microorganisms. These results demonstrate how microbial nutrient acquisition belowground of A. adenophora along an altitudinal gradient, which could contribute to further knowledge about the effects of altitude on biological invasion.
Private Tabular Survey Data Products through Synthetic Microdata Generation
Authors: Hu Jingchen , Savitsky Terrance D , Williams Matthew R 
Published: January 2022

Abstract
We propose two synthetic microdata approaches to generate private tabular survey data products for public release. We adapt a pseudo posterior mechanism that downweights by-record likelihood contributions with weights ∈[0,1] based on their identification disclosure risks to producing tabular products for survey data. Our method applied to an observed survey database achieves an asymptotic global probabilistic differential privacy guarantee. Our two approaches synthesize the observed sample distribution of the outcome and survey weights, jointly, such that both quantities together possess a privacy guarantee. The privacy-protected outcome and survey weights are used to construct tabular cell estimates (where the cell inclusion indicators are treated as known and public) and associated standard errors to correct for survey sampling bias. Through a real data application to the Survey of Doctorate Recipients public use file and simulation studies motivated by the application, we demonstrate that our two microdata synthesis approaches to construct tabular products provide superior utility preservation as compared to the additive noise approach of the Laplace Mechanism. Moreover, our approaches allow the release of microdata to the public, enabling additional analyses at no extra privacy cost.
The bud dormancy disconnect: latent buds of grapevine are dormant during summer despite a high metabolic rate
Authors: Velappan Yazhini , Chabikwa Tinashe G , Considine John A , Agudelo-Romero Patricia , Foyer Christine H , Signorelli Santiago , Considine Michael J 
Published: January 2022

AbstractGrapevine (Vitis vinifera L.) displays wide plasticity to climate; however, the physiology of dormancy along a seasonal continuum is poorly understood. Here we investigated the apparent disconnect between dormancy and the underlying respiratory physiology and transcriptome of grapevine buds, from bud set in summer to bud burst in spring. The establishment of dormancy in summer was pronounced and reproducible; however, this was coupled with little or no change in physiology, indicated by respiration, hydration, and tissue oxygen tension. The release of dormancy was biphasic; the depth of dormancy declined substantially by mid-autumn, while the subsequent decline towards spring was moderate. Observed changes in physiology failed to explain the first phase of dormancy decline, in particular. Transcriptome data contrasting development from summer through to spring also indicated that dormancy was poorly reflected by metabolic quiescence during summer and autumn. Gene Ontology and enrichment data revealed the prevailing influence of abscisic acid (ABA)-related gene expression during the transition from summer to autumn, and promoter motif analysis suggested that photoperiod may play an important role in regulating ABA functions during the establishment of dormancy. Transcriptomic data from later transitions reinforced the importance of oxidation and hypoxia as physiological cues to regulate the maintenance of quiescence and resumption of growth. Collectively these data reveal a novel disconnect between growth and metabolic quiescence in grapevine following bud set, which requires further experimentation to explain the phenology and dormancy relationships.
Assessment of panfungal PCR performance with formalin-fixed paraffin-embedded tissue specimens
Authors: Clark Shawn T , Yau Yvonne C W , Campigotto Aaron , Gharabaghi Farhad , Richardson Susan E , Tadros Manal 
Published: January 2022

Abstract

We reviewed the performance of a panfungal ITS-2 PCR and Sanger sequencing assay performed on 88 FFPE specimens at The Hospital for Sick Children (Toronto, Canada) in 2019. A potential fungal pathogen was identified by ITS PCR in 62.7 and 2.9% of positive and negative direct slide examination of tissue specimens, respectively. ITS amplicons were detected in 87/88 specimens, with 53/88 (60.2%) considered as ‘positive-contaminants’ and 34/88 (38.6%) as ‘positive-potential pathogen’ upon sequencing. Potential pathogens included Blastomyces dermatitidis (17.1%), Cryptococcus neoformans (17.1%), Histoplasma capsulatum (14.3%) and Mucormycetes (11.4%). Laboratories should only perform ITS PCR on FFPE tissues if fungal elements have been confirmed on histopathology slides.

Lay summary
In this study, we examined how well a DNA-based test could detect DNA from fungi in archived human biopsy tissues. The best performance was achieved if fungi were seen in the tissue under a microscope before being tested. Our results indicate that we should only use this test if these conditions are met.
UNITSIM-Galaxies: data release and clustering of emission-line galaxies
Authors: Knebe Alexander , Lopez-Cano Daniel , Avila Santiago , Favole Ginevra , Stevens Adam R H , Gonzalez-Perez Violeta , Reyes-Peraza Guillermo , Yepes Gustavo , Chuang Chia-Hsun , Kitaura Francisco-Shu 
Published: January 2022

ABSTRACT
New surveys such as European Space Agencys (ESA’s) Euclid mission are planned to map with unprecedented precision the large-scale structure of the Universe by measuring the 3D positions of tens of millions of galaxies. It is necessary to develop theoretically modelled galaxy catalogues to estimate the expected performance and to optimize the analysis strategy of these surveys. We populate two pairs of (1 h−1 Gpc)3 volume dark matter-only simulations from the UNIT project with galaxies using the Semi-Analytic Galaxy Evolution semi-analytic model of galaxy formation, coupled to the photoionization model get_emlines to estimate their H α emission. These catalogues represent a unique suite that includes galaxy formation physics and – thanks to the fixed-pair technique used – an effective volume of $\sim\!(5\,h^{-1}\,\rm {Gpc})^3$, which is several times larger than the Euclid survey. We present the performance of these data and create five additional emission-line galaxy (ELG) catalogues by applying a dust-attenuation model as well as adjusting the flux threshold as a function of redshift in order to reproduce Euclid-forecast dN/dz values. As a first application, we study the abundance and clustering of those model H α ELGs: for scales greater than ∼5 h−1 Mpc, we find a scale-independent bias with a value of b ∼ 1 at redshift z ∼ 0.5, that can increase nearly linearly to b ∼ 4 at z ∼ 2, depending on the ELG catalogue. Model galaxy properties, including their emission-line fluxes (with and without dust extinction) are publicly available.
Probing the electron-to-proton mass ratio gradient in the Milky Way with Class I methanol masers
Authors: Levshakov S A , Agafonova I I , Henkel C , Kim Kee-Tae , Kozlov M G , Lankhaar B , Yang W 
Published: January 2022

ABSTRACT
We estimate limits on non-universal coupling of hypothetical hidden fields to standard matter by evaluating the fractional changes in the electron-to-proton mass ratio, μ = me/mp, based on observations of Class I methanol masers distributed in the Milky Way disc over the range of the Galactocentric distances $4 \lesssim R \lesssim 12$ kpc. The velocity offsets ΔV = V44 − V95 measured between the 44- and 95-GHz methanol lines provide, so far, one of the most stringent constraints on the spatial gradient kμ ≡ d(Δμ/μ)/dR &lt; 2 × 10−9 kpc−1 and the upper limit on Δμ/μ &lt;2 × 10−8, where Δμ/μ = $(\mu _{\rm \scriptscriptstyle obs}-\mu _{\rm \scriptscriptstyle lab})/\mu _{\rm \scriptscriptstyle lab}$. We also find that the offsets ΔV are clustered into two groups which are separated by $\delta _{\scriptscriptstyle \Delta V} = 0.022 \pm 0.003$ km s−1 (1σ confidence level). The grouping is most probably due to the dominance of different hyperfine transitions in the 44- and 95-GHz methanol maser emission. Which transition becomes favoured is determined by an alignment (polarization) of the nuclear spins of the four hydrogen atoms in the methanol molecule. This result confirms that there are preferred hyperfine transitions involved in the methanol maser action.
Relativistic oblique shocks with ordered or random magnetic fields: tangential field governs
Authors: Ma Jing-Ze , Zhang Bing 
Published: January 2022

ABSTRACT
Relativistic magnetohydrodynamic shocks are efficient particle accelerators, often invoked in the models of gamma-ray bursts (GRBs) and shock-powered fast radio bursts (FRBs). Most theoretical studies assume a perpendicular shock with an ordered magnetic field perpendicular to the shock normal. However, the degree of magnetization σ and the magnetic field geometry in shock-powered GRB/FRB scenarios are still poorly constrained by observations. Analogous to the magnetization σ associated with the total field strength, we define a tangential magnetization σ⊥ associated with the tangential field component. We explore the jump conditions of magnetized relativistic shocks, either with an ordered field of arbitrary inclination angle or with a random field of arbitrary anisotropy. In either case, we find that the jump conditions of relativistic shocks are governed by the tangential magnetization σ⊥ instead of the total magnetization σ, insensitive to the inclination angles or the anisotropy of the pre-shock magnetic field. The approximated analytical solution developed in this work could serve as a quick check for numerical simulations and apply to theoretical studies of GRBs/FRBs with a more general field geometry.