bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flare on [18F]PSMA-1007 PET/CT after short-term androgen deprivation therapy and its correlation to FDG uptake: possible marker of tumor aggressiveness in treatment-naïve metastatic prostate cancer patients
Authors: Malaspina Simona , Ettala Otto , Tolvanen Tuula , Rajander Johan , Eskola Olli , Boström Peter. J. , Kemppainen Jukka 
Published: September 2022

Abstract

Purpose
Short-term androgen deprivation therapy (ADT) is known to increase heterogeneously prostate-specific membrane antigen (PSMA) expression. This phenomenon might indicate the potential of cancer lesions to respond to ADT. In this prospective study, we evaluated the flare on [18F]PSMA-1007 PET/CT after ADT in metastatic prostate cancer (PCa). Given that aggressive PCa tends to display FDG uptake, we particularly investigated whether the changes in PSMA uptake might correlate with glucose metabolism.

Methods
Twenty-five men with newly diagnosed treatment-naïve metastatic PCa were enrolled in this prospective registered clinical trial. All the patients underwent [18F]PSMA-1007 PET/CT immediately before and 3–4 weeks after ADT initiation (degarelix). Before ADT, [18F]FDG PET/CT was also performed. Standardized uptake values (SUV)max of primary and metastatic lesions were calculated in all PET scans. Serum PSA and testosterone blood samples were collected before the two PSMA PET scans. The changes in PSMA uptake after ADT were represented as ΔSUVmax.

Results
All the patients reached castration levels of testosterone at the time of the second [18F]PSMA-1007 PET/CT. Overall, 57 prostate, 314 lymph nodes (LN), and 406 bone lesions were analyzed. After ADT, 104 (26%) bone, 33 (11%) LN, and 6 (11%) prostate lesions showed an increase (≥ 20%) in PSMA uptake, with a median ΔSUVmax of + 50%, + 60%, and + 45%, respectively. Among the lesions detected at the baseline [18F]PSMA-1007 PET/CT, 63% bone and 46% LN were FDG-positive. In these metastases, a negative correlation was observed between the PSMA ΔSUVmax and FDG SUVmax (p < 0.0001). Moreover, a negative correlation between the ΔSUVmax and the decrease in serum PSA after ADT was noted (p < 0.0001).

Conclusions
A heterogeneous increase in PSMA uptake after ADT was detected, most evidently in bone metastases. We observed a negative correlation between the PSMA flare and the intensity of glucose uptake as well as the decrease of serum PSA, suggesting that lesions presenting with such flare might potentially be less aggressive.

Trial registration
NCT03876912, registered 15 March 2019.
Robotic versus laparoscopic transabdominal preperitoneal (TAPP) approaches to bilateral hernia repair: a multicenter retrospective study using propensity score matching analysis
Authors: Peltrini Roberto , Corcione Francesco , Pacella Daniela , Castiglioni Simone , Lionetti Ruggero , Andreuccetti Jacopo , Pignata Giusto , De Nisco Carlo , Ferraro Luca , Salaj Adelona , Formisano Giampaolo , Bianchi Paolo Pietro , Bracale Umberto 
Published: September 2022

Abstract
Background
Since the introduction of minimally invasive surgery, new techniques like transabdominal preperitoneal (TAPP) repair have progressively gained acceptance for the treatment of groin hernia. Laparoscopic TAPP (LTAPP) is recommended for bilateral repairs. Likewise, the introduction of robotic platforms has promised additional surgical benefits for robotic TAPP (RTAPP), which are yet to be confirmed. This study compared multicenter data obtained from patients undergoing bilateral inguinal hernia repair with RTAPP, performed during the preliminary learning curve period, versus conventional LTAPP.

Materials and methods
All consecutive bilateral inguinal hernia patients from four Italian centers between June 2015 and July 2020 were selected. A propensity score model was used to compare patients treated with LTAPP versus RTAPP, considering sex, age, body mass index, current smoking status, overall comorbidity, hernia classification (primary or recurrent), and associated procedures as covariates. After matching, intraoperative details and postoperative outcomes were evaluated.

Results
In total, 275 LTAPP and 40 RTAPP were performed. After matching, 80 and 40 patients were allocated to the LTAPP and RTAPP cohorts, respectively. No intraoperative complications or conversion to open surgery occurred. However, a longer operative time was recorded in the RTAPP group (79 ± 21 versus 98 ± 29 min; p < 0.001). Postoperative visual analog scale (VAS) pain scores (p = 0.13) did not differ and complication rates were similar. There were no clinical recurrences in either group, with mean follow-up periods of 52 ± 14 (LTAPP) and 35 ± 8 (RTAPP) months. A statistical difference in length of hospital stay was found between the groups (1.05 ± 0.22 vs 1.50 ± 0.74 days; p < 0.001).

Conclusion
In this patient population, outcomes for bilateral inguinal hernia repair appear comparable for RTAPP and LTAPP, except for a shorter recovery after laparoscopic surgery. A longer operative time for robotic surgery could be attributable to the learning curve period of each center.
Suspected common bile duct stones: reduction of unnecessary ERCP by pre-procedural imaging and timing of ERCP
Authors: Sperna Weiland Christina J. , Verschoor Evelien C. , Poen Alexander C. , Smeets Xavier J. M. N. , Venneman Niels G. , Bhalla Abha , Witteman Ben J. M. , Timmerhuis Hester C. , Umans Devica S. , van Hooft Jeanin E. , Bruno Marco J. , Fockens P. , Verdonk Robert C. , Drenth Joost P. H. , van Geenen Erwin J. M. ,   for the Dutch Pancreatitis Study Group
Published: September 2022

Abstract
Background
Endoscopic retrograde cholangiopancreatography (ERCP) is the procedure of choice to remove sludge/stones from the common bile duct (CBD). In a small but clinically important proportion of patients with suspected choledocholithiasis ERCP is negative. This is undesirable because of ERCP associated morbidity. We aimed to map the diagnostic pathway leading up to ERCP and evaluate ERCP outcome.

Methods
We established a prospective multicenter cohort of patients with suspected CBD stones. We assessed the determinants that were associated with CBD sludge or stone detection upon ERCP.

Results
We established a cohort of 707 patients with suspected CBD sludge or stones (62% female, median age 59 years). ERCP was negative for CBD sludge or stones in 155 patients (22%). Patients with positive ERCPs frequently had pre-procedural endoscopic ultrasonography (EUS) or magnetic resonance cholangiopancreatography (MRCP) imaging (44% vs. 35%; P = 0.045). The likelihood of ERCP sludge and stones detection was higher when the time interval between EUS or MRCP and ERCP was less than 2 days (odds ratio 2.35; 95% CI 1.25–4.44; P = 0.008; number needed to harm 7.7).

Conclusions
Even in the current era of society guidelines and use of advanced imaging CBD sludge or stones are absent in one out of five ERCPs performed for suspected CBD stones. The proportion of unnecessary ERCPs is lower in case of pre-procedural EUS or MRCP. A shorter time interval between EUS or MRCP increases the yield of ERCP for suspected CBD stones and should, therefore, preferably be performed within 2 days before ERCP.

Graphical abstract
Alcohol consumption habits and associations with anxiety or depressive symptoms postpartum in women with high socioeconomic status in Sweden
Authors: Lager Susanne , Gidén Karin , Axfors Cathrine , Sigvardsson Frida , Kollia Natasa , Nylander Ingrid , Fransson Emma , Skalkidou Alkistis 
Published: September 2022

AbstractPostpar
tum depression and anxiety are common among new mothers. It is well-established that in the general population alcohol use is associated with depression and anxiety. Linking alcohol consumption to symptoms of postpartum depression (PPDS) or postpartum anxiety (PPAS) is presently less established. This study aims to determine if alcohol consumption pre-pregnancy, 6 weeks postpartum, 6 months postpartum, or changes in alcohol consumption are associated with PPDS or PPAS. Longitudinal data on 3849 women from a Swedish perinatal cohort were analyzed using logistic regression analyses for associations between alcohol consumption and symptoms of anxiety or depression, as assessed with the Edinburgh Postnatal Depression Scale. There was no association between pre-pregnancy drinking habits and PPDS (p = 0.588, n = 2479) or PPAS (p = 0.942; n = 2449) at 6 weeks postpartum. Similarly, no associations were observed between concurrent drinking habits at 6 weeks postpartum and PPAS (p = 0.070, n = 3626), 6 months postpartum and PPDS (0.647, n = 3461) or PPAS (p = 0.700, n = 3431). However, there was an association between drinking habits at 6 weeks postpartum and concurrent PPDS (p = 0.047, n = 3659). In conclusion, robust associations were not found between postpartum alcohol consumption and mood symptoms. This lack of association between poor mental health and risk behaviors in new mothers could be interpreted as a result of long-term policy work and high participation in Swedish maternity care. Future studies need to address these research questions in more diverse socio-cultural contexts.
Longitudinal angiographic characterization of the efficacy of combined cerebral revascularization using minimally invasive encephalodurosynangiosis in patients with moyamoya angiopathy
Authors: Lucia K. , Acker G. , Mrosk F. , Beyaztas D. , Vajkoczy Peter 
Published: September 2022

AbstractMoyamoya angiopathy (MMA) can be treated using direct, indirect, or combined revascularization procedures. We perform combined revascularization using the STA-MCA bypass and minimally invasive encephalodurosynangiosis (MIS-EDS). Due to lack of systematic analyses to date it remains unclear whether and to which extent this limited EDS serves as a growth source for extracerebral blood vessels into the brain. The objective of the current study is to characterize the extent of angiographic filling of MIS-EDS and STA-MCA bypass development over time and to determine possible predictors of EDS development in adult MMA patients. Single-center retrospective analysis of 81 MMA patients (139 hemispheres) treated with a MIS-EDS and STA-MCA bypass was performed. Angiographic images and clinical/operative data were reviewed and scored. Uni-/ and multivariate Cox regression analyses identified preoperative predictors of good EDS vascularization. At 3–6 months after surgery EDS showed moderate and high angiographic filling in 40% and 5% of hemispheres, respectively. After 12 months moderate and high filling was found in 57% and 4% of hemispheres, respectively. STA-MCA bypass filling was moderate in 47% and high in 7% of hemispheres at 3–6 months and 45% moderate and 9% high after 12 months. High STA-MCA bypass filling on angiography was a negative predictor of EDS development. MIS-EDS is a simple technique and serves as a source of vessel growth into the brain. EDS development lags behind that of STA-MCA bypass and can be recommended as an additive revascularization source when combined with a direct bypass.
Population and conservation genetics using RAD sequencing in four endemic conifers from South America
Authors: Cano Mauricio J. , Twyford Alex D. , Hollingsworth Peter M. 
Published: September 2022

AbstractThe emblematic conifer flora of Chile has experienced wide-scale habitat loss and fragmentation. Coupled with the complex topography of the region, this leads to a prediction of high levels of genetic drift and isolation resulting in strong population differentiation, and the potential for negative genetic consequences. To address the degree to which these predictions are realised, we conducted a comparative population genetic survey in four endemic conifers from South America, each of conservation concern and with a restricted distribution area. Between seven and ten populations per species were sampled, covering their entire natural distribution in Chile. We used restriction site-associated DNA markers (RAD-seq), with de novo assembly and optimisation, to accommodate the large and complex genome of conifers. The main finding was low levels of genetic structure in all four conifer species (FST = 0.017–0.062). This pattern was strikingly consistent across all four species. These results are likely due to the extreme longevity of individuals restricting divergence due to genetic drift. Thus, despite the currently highly fragmented ranges of these conifer species, we did not detect evidence for high levels of population differentiation and genetic isolation. This suggests some resilience to negative genetic impacts of habitat fragmentation, and the longevity of the individual trees may provide considerable buffering capacity. We recommend follow-up studies focusing on genotyping the seedling generation, to assess whether there is any evidence for the early warning of genetic isolation and/or elevated inbreeding in the currently established cohorts.
Commentary to biodiversity and conservation Upgrading Birgus: lessons for invertebrate conservation
Authors: Caro Tim 
Published: September 2022

AbstractCoconut crabsBirgus latrohave recently been reclassified from Data Deficient to Vulnerable on the IUCN Red List. This is a somewhat unusual case of temporal and spatial information being used to change the IUCN status of an arthropod and it draws attention to the paucity of biological data on most invertebrate species. To be listed, two or more scientific criteria need to be documented but such data are unavailable for many invertebrates. This raises the question as to whether certain invertebrates receive more scientific attention and are hence more likely to be listed if, like the coconut crab, they are large, slow-reproducing or a dual-biome species (characteristics which make them inherently vulnerable) and whether being an indicator or a flagship species is important.
Explaining Prejudicial Attitudes and Bias-Motivated Aggression in Belgium: a Comparison of Individual-Level Theoretical Models
Authors: Pauwels Lieven J. R. , Williamson Harley 
Published: September 2022

AbstractPrejudice and bias-motivated aggression (BMA) are pervasive social problems. Scholars have tested numerous competing theoretical models to demonstrate the key predicates of prejudice and BMA, including intergroup contact, dual process (i.e., right-wing authoritarianism and social dominance orientation), perceived injustice, peer socialization, and empathy. Yet, studies to date have not empirically examined the comparative strength of these theoretical perspectives to explain the correlates of (a) prejudice and (b) BMA. This study seeks to address this gap. Utilizing a sample of young 1,001 Belgian participants, this study explores the association between key constructs from different theoretical perspectives to better understand prejudice and BMA towards immigrant populations. Findings show that when accounting for all models of prejudice and BMA, the strongest predictors of prejudice emerge from the dual-process model, the empathy model (outgroup empathy), and the quality (not frequency) of intergroup contact. Yet, prejudice and exposure to peer outgroup hostility are the strongest predictors of BMA. We discuss the implications of our findings and suggest that drawing on criminological theories of prejudice and BMA can be integrated to provide a more nuanced understanding of the nature of prejudice and BMA than what is currently known. We conclude by highlighting some directions for future research on prejudice and BMA.
Trust and Distrust in Pension Providers in Times of Decline and Reform: Analysis of Survey Data 2004–2021
Authors: van Dalen Hendrik P. , Henkens Kène 
Published: September 2022

AbstractTrust in pension providers by participants is essential because pension providers try to fulfill their pension promises in a fundamentally uncertain world. Reforms and crises are therefore the ultimate testing ground for pension trust. In this paper we estimate with repeated cross-sectional survey data how trust and distrust in Dutch pension funds and the government have evolved over the period 2004–2021 and what the impact of financial stability on trust in these two institutions has been. Financial stability of pension funds, measured by their funding ratio, is shown to affect trust positively, but it does not decrease distrust significantly. Based on the estimation results, achieving a situation where the majority of the adult population trusts pension funds is likely to be attained at funding ratios of 115 or higher. Financial stability of government (measured by government debt/GDP ratio) does not affect either trust or distrust levels. Underlying drivers of distrust and trust such as personal characteristics are also notable: self-employed are more prone to distrust pension funds than employees. Women are more than men likely to take a neutral position.
Conductivity Properties of Perovskite Nickelates and Cuprates Depend on the Oxidation States of the Metal Ions
Authors: Larsson Sven 
Published: September 2022

AbstractSuperconducting nickelates in thin film perovskite structures, designed to be isostructural with the Cu(II) cuprates, have been discovered recently by Zhou et al. (Appl. Mater. Interfaces 10, 1463-1467, 1) and Li et al. (Nature 572, 624-627, 2) The strategies of both groups, to make nickelates as similar to the cuprates as possible by using planar NiO2 superlattice structures, proved successful. Ni(I) and Ni(III) are superconducting in superlattices, although TC is lower than in most Cu(II) cuprates. Here we find that a “3-oxidation states rule” applies to nickelate superlattices based on Ni(I) and Ni(III). It is predicted that the oxides of Ni(II), Cu(I), and Cu(III) cannot superconduct, because of violation of the 3-rule. This rule is derived here, along with other rules where the number of interacting oxidation states is decisive for the conduction properties of the metal ion. The Mott model is replaced by a free energy model.
Joint Invariance Principles for Random Walks with Positively and Negatively Reinforced Steps
Authors: Bertenghi Marco , Rosales-Ortiz Alejandro 
Published: September 2022

AbstractGiven a random walk $$(S_n)$$

(

S
n

)

with typical step distributed according to some fixed law and a fixed parameter $$p \in (0,1)$$

p
∈
(
0
,
1
)

, the associated positively step-reinforced random walk is a discrete-time process which performs at each step, with probability $$1-p$$

1
-
p

, the same step as $$(S_n)$$

(

S
n

)

while with probability p, it repeats one of the steps it performed previously chosen uniformly at random. The negatively step-reinforced random walk follows the same dynamics but when a step is repeated its sign is also changed. In this work, we shall prove functional limit theorems for the triplet of a random walk, coupled with its positive and negative reinforced versions when $$p < 1/2$$

p
<
1
/
2

and when the typical step is centred. The limiting process is Gaussian and admits a simple representation in terms of stochastic integrals, $$\begin{aligned} \left( B(t) , \, t^p \int _0^t s^{-p} \mathrm {d}B^r(s) , \, t^{-p} \int _0^t s^{p} \mathrm {d}B^c(s) \right) _{t \in \mathbb {R}^+} \end{aligned}$$

B

(
t
)

,

t
p

∫
0
t

s

-
p

d

B
r

(
s
)

,

t

-
p

∫
0
t

s
p

d

B
c

(
s
)

t
∈

R

+

for properly correlated Brownian motions $$B, B^r$$

B
,

B
r

, $$B^c$$

B
c

. The processes in the second and third coordinate are called the noise reinforced Brownian motion (as named in [1]), and the noise counterbalanced Brownian motion of B. Different couplings are also considered, allowing us in some cases to drop the centredness hypothesis and to completely identify for all regimes $$p \in (0,1)$$

p
∈
(
0
,
1
)

the limiting behaviour of step reinforced random walks. Our method exhausts a martingale approach in conjunction with the martingale functional CLT.
Analysis of Complex Absorption After Multiple Dosing: Application to the Interaction Between the P-glycoprotein Substrate Talinolol and Rifampicin
Authors: Weiss Michael , D’Argenio David Z. , Siegmund Werner 
Published: September 2022

Abstract

Purpose
In order to clarify the effect of rifampicin on the bioavailability of the P-glycoprotein substrate talinolol, its absorption kinetics was modeled after multiple-dose oral administration of talinolol in healthy subjects.

Methods
A sum of two inverse Gaussian functions was used to calculate the time course of the input rate into the systemic circulation.

Results
The estimated rate of drug entry into the systemic circulation revealed two distinct peaks at 1 and 3.5 h after administration. Rifampicin did not affect bioavailability of talinolol, but did shift the second peak of the input function by 1.3 h to later times. Elimination clearance and one of the intercompartmental distribution clearances increased significantly under rifampicin treatment.

Conclusions
Rifampicin changes the time course of absorption rate but not the fraction absorbed of talinolol. The model suggests the existence of two intestinal absorption windows for talinolol.
Starvation and Re-lubrication in Oscillating Bearings: Influence of Grease Parameters
Authors: Wandel Sebastian , Bader Norbert , Glodowski Jakob , Lehnhardt Bela , Leckner Johan , Schwack Fabian , Poll Gerhard 
Published: September 2022

AbstractA common application for grease-lubricated oscillating rolling element bearings is, e.g., rotor blade bearings in wind turbines. These bearings mainly operate under conditions that are prone to starvation. If the grease is unable to provide enough inlet lubricant supply for the contact between rolling element and bearing raceway, wear in the form of False Brinelling and thus premature bearing failure is possible. Bearing experiments with different lithium complex model greases, which differ mainly in their base oil viscosity and oil separation rate, were carried out to show the influence of the grease parameters on wear initiation. The results show that the ability of the grease to release a high amount of base oil with high mobility into the track of the rolling element is a crucial mechanism to prevent wear, especially at small oscillation angles. For oscillation angles larger than a critical angle, a secondary replenishment mechanism may prevent early wear initiation. The experimental results are used to validate a starvation model proposed in earlier work (Wandel et al. in Tribol Int 165:107276, 2022).
Association of PRLR, IGF1, and LEP genes polymorphism with milk production and litter size in Egyptian Zaraibi goat
Authors: El-Shorbagy Haidan M. , Abdel-Aal Ehab S. , Mohamed Shaimaa A. , El-Ghor Akmal A. 
Published: September 2022

AbstractStudying variation in genes responsible for physiological characters is important to enhance goat productive and reproductive efficiency. This study aimed to detect specific nucleotide polymorphisms in prolactin receptor (PRLR), insulin-like growth factor (IGF1), and leptin (LEP) genes and their correlation with milk production (MP) and litter size (LS) traits in Zaraibi goat. PCR-SSCP products of different patterns of each gene were sequenced and aligned to reveal two mutations (T > C) and (G > A) in 3′UTR of PRLR gene and registered on NCBI with accession numbers OM418863 for TT and OM418864 for CT, while (G > A) variation was registered as OM418861 for GG and OM418862 for AG in exon 10. TT, CT, AG, and GG genotypes were distributed in the studied animals with frequencies 0.43, 0.57, 0.65, and 0.35, respectively. While alleles C, T, A, and G frequencies were 0.28, 0.72, 0.32, and 0.68, respectively. CT and AG genotypes associated significantly (P < 0.05) with higher MP and LS, respectively. By studying the haplotypes of PRLR, C-A and T-A were associated with the highest and the lowest level of MP, respectively. For LS, T-A and C-G showed significant correlation with the highest and the lowest rate, respectively. Regarding IGF1 gene, two polymorphisms were detected; T74C at exon 4 which registered on NCBI as OM418860, and combined mutations as ins. G470, A531G, and T534C (PP genotype) at 5′ flanking region that registered as OM418859. For LEP, only one polymorphism was found in intron 2 (G281A) which submitted to NCBI as OM418855. All detected polymorphisms have shown to be involved in regulating the MP or LS as reproductive traits in goat.