bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-incision port robot-assisted surgery for thymic carcinoid tumor resection
Authors: Shidei Hiroaki , Mitsuboshi Shota , Yamamoto Tomoko , Kanzaki Masato 
Published: May 2022

Abstract
Background
Multiple endocrine neoplasia (MEN) is divided into MEN type 1 (MEN-1) and MEN type 2 (MEN-2). MEN-1 may be associated with thymic carcinoid tumors. We present a case of the surgical removal of a thymic carcinoid associated with MEN-1 via a single-incision port RATS.

Case presentation
A 39-year-old male patient with multiple endocrine neoplasia type 1 (MEN-1) who had an anterior mediastinal mass was referred to our hospital. The patient had undergone total parathyroidectomy and auto-transplantation of a partial parathyroid for hyperparathyroidism 6 years ago. Chest computed tomography revealed an isolated anterior mediastinal mass on the thymic gland with a maximum diameter measuring 22 mm. Thymic carcinoid tumor is classified as MEN-1 and has a poor prognosis, so we decided to remove the tumor. Single-incision port RATS was performed, and thymic carcinoid was confirmed in pathology.

Conclusions
This report demonstrates that thymic carcinoid tumor removal is feasible and easy to perform via single-incision port RATS.
Prevalence of active trachoma and associated factors among school age children in Debre Tabor Town, Northwest Ethiopia, 2019: a community based cross-sectional study
Authors: Shimelash Alebachew , Alemayehu Mekuriaw , Dagne Henok , Mihiretie Getenet , Lamore Yonas , Tegegne Eniyew , Kumlachew Lake 
Published: May 2022

Abstract
Background
Trachoma is an infectious eye disease caused by Chlamydial trachomatis. It is a major health problem in poor nations, notably in Sub-Saharan Africa. Despite the severity of the problem, there was a scarcity of data on trachoma prevalence and associated factors among school-aged children in Debre Tabor town following SAFE and MDA.

Objectives
The goal of this study was to determine the prevalence of active trachoma and its associated factors among school-aged children in Debre Tabor, Northwest Ethiopia, in 2019.

Methods
A community-based cross-sectional study was used among school-aged children. Structured interview questionnaires, an observational checklist, and a physical examination were used to collect data from study participants who were chosen using a systematic random sampling procedure. IBM SPSS 20 was used to enter data, which was then transferred to IBM SPSS 20 for bivariate and multivariable logistic regression analysis.

Result
A total of 394 children aged 5–15 had been screened and took part in the study, with 9.9% (95% CI: 6.9, 12.7) testing positive for active trachoma. Having an unimproved larine type (AOR = 5.18; 95%CI: 1.96, 13.69), improper solid waste disposal (AOR = 3.026; 95%CI: 1.17, 7.8), family size greater than four (AOR = 3.4; 95%CI: 1.22, 9.49), not using soap for face washing (AOR = 4.48; 95%CI: 1.46, 13.72) and an unclean face of the child during examination (AOR = 23.93; 95%CI: 8.25, 69.38) were found to be significant predictors of active trachoma.

Conclusion
Active trachoma among school-age children was high compared to the WHO’s definition of trachoma as a public health problem. A family size of four, poor solid waste management, an unimproved type of latrine, an unclean child's face, and not using soap when washing one's face were all significant predictors of active trachoma. Promotion of behavioral determinants through health education programs like keeping facial cleanliness by washing their child’s face with soap, managing solid waste properly, and installing improved latrines to reduce active trachoma needs to be in place.
Comparison of the predictive ability of clinical frailty scale and hospital frailty risk score to determine long-term survival in critically ill patients: a multicentre retrospective cohort study
Authors: Subramaniam Ashwin , Ueno Ryo , Tiruvoipati Ravindranath , Srikanth Velandai , Bailey Michael , Pilcher David 
Published: May 2022

Abstract
Background
The Clinical Frailty Scale (CFS) is the most commonly used frailty measure in intensive care unit (ICU) patients. The hospital frailty risk score (HFRS) was recently proposed for the quantification of frailty. We aimed to compare the HFRS with the CFS in critically ill patients in predicting long-term survival up to one year following ICU admission.

Methods
In this retrospective multicentre cohort study from 16 public ICUs in the state of Victoria, Australia between 1st January 2017 and 30th June 2018, ICU admission episodes listed in the Australian and New Zealand Intensive Care Society Adult Patient Database registry with a documented CFS, which had been linked with the Victorian Admitted Episode Dataset and the Victorian Death Index were examined. The HFRS was calculated for each patient using the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes that represented pre-existing conditions at the time of index hospital admission. Descriptive methods, Cox proportional hazards and area under the receiver operating characteristic (AUROC) were used to investigate the association between each frailty score and long-term survival up to 1 year, after adjusting for confounders including sex and baseline severity of illness on admission to ICU (Australia New Zealand risk-of-death, ANZROD).

Results
7001 ICU patients with both frailty measures were analysed. The overall median (IQR) age was 63.7 (49.1–74.0) years; 59.5% (n = 4166) were male; the median (IQR) APACHE II score 14 (10–20). Almost half (46.7%, n = 3266) were mechanically ventilated. The hospital mortality was 9.5% (n = 642) and 1-year mortality was 14.4% (n = 1005). HFRS correlated weakly with CFS (Spearman’s rho 0.13 (95% CI 0.10–0.15) and had a poor agreement (kappa = 0.12, 95% CI 0.10–0.15). Both frailty measures predicted 1-year survival after adjusting for confounders, CFS (HR 1.26, 95% CI 1.21–1.31) and HFRS (HR 1.08, 95% CI 1.02–1.15). The CFS had better discrimination of 1-year mortality than HFRS (AUROC 0.66 vs 0.63 p < 0.0001).

Conclusion
Both HFRS and CFS independently predicted up to 1-year survival following an ICU admission with moderate discrimination. The CFS was a better predictor of 1-year survival than the HFRS.
Continuous controlled cone metric-type spaces over real Banach algebras and fixed-point results
Authors: Ullah Wahid , Işık Hüseyin , Alam Nouman , Park Choonkil , Lee Jung Rye 
Published: May 2022

AbstractIn this article, we introduce a new geometrical structure that is the hybrid of a cone metric space over Banach algebra and a controlled metric-type space. We introduce a new metric space and prove analogs of Banach-, Kannan- and Reich-type fixed-point theorems. We also furnish various concrete examples to establish the validity of our results. The obtained results generalize many well-known results in the literature.
Validation of the factor structure and psychometric characteristics of the Arabic adaptation of the sense of coherence SOC-13 scale: a confirmatory factor analysis
Authors: Alharbi Fatimah Sayer , Aljemaiah Abdulaziz I. , Osman Mugtaba 
Published: May 2022

Abstract
Background
The sense of coherence is as focused on one’s awareness of the level of pervasive, enduring, and dynamic feelings. Stronger sense of coherence leads to better physical and mental health and promotes recovery from life stressors. Sense of coherence-13 (SOC-13) is a 13-item valid and reliable measure for individual’s healthy living. However, the factor structure of SOC-13 was criticized in several cultures and languages. The current study was set to explore the factor structure of an Arabic adaptation for SOC-13.

Methods
This cross-sectional study of the SOC-13 included (n = 1235) Arabic speaking individuals. We used confirmatory factor analysis to contrast unidimensional, bidimensional, three-dimensional, and four-dimensional factor structure for the SOC-13. We carried out measurement invariance analysis across age and gender groups to examine the stability of fit indices among participants’ subgroups.

Results
We found the reliability coefficient to be 0.82, indicative of good internal consistency. The three-factor structure, after modification of items 1, 2, and 3 was the best-fitting factor model. However, measurement invariance was indicative of discrepancy for the three-factor model between genders and age classes. The mean overall SOC-13 total score in our sample was 52.1 (SD = 16.1).

Conclusions
The SOC-13 showed acceptable psychometric properties in terms of internal consistency and a modified three-factor structure in its Arabic version. However, the reliability of the three underlying dimensions was sub-optimum. Moreover, the three-factor structure requires modification by either removing the first three problematic items or allowing the residuals to correlate.
The comparative study of color doppler flow imaging, superb microvascular imaging, contrast-enhanced ultrasound micro flow imaging in blood flow analysis of solid renal mass
Authors: Mao Yiran , Mu Jie , Zhao Jing , Yang Fan , Zhao Lihui 
Published: May 2022

Abstract
Purposes
To evaluate the value of Color Doppler Flow Imaging (CDFI), Superb Microvascular Imaging (SMI) and Contrast-enhanced Ultrasound Microflow Imaging (MFI) in display the microvascular blood flow signals in renal solid lesions.

Methods
142 patients with 144 renal masses were examined by CDFI, SMI and MFI simultaneously. We compared the difference of blood flow grading and vascular architecture based on CDFI, SMI and MFI.

Results
The blood flow signals detection rates of CDFI, SMI and MFI were 78.5% (113/144), 88.9% (128/144) and 93.8% (135/144), respectively. Concentrated on blood flow grading, The coincidence rates of CDFI and SMI were 64.58% (93/144) and 81.25% (117/144) referring to MFI, respectively. Blood flow grade 2–3 in CDFI is significantly lower than SMI(x2 = 5.557, P = 0.018) and MFI (x2 = 10.165, P = 0.001). Whereas there was no significant difference between SMI and MFI (x2 = 2.372, P = 0.499). Concentrated on vascular architecture, the coincidence rates of CDFI and SMI were 56.25% (81/144) and 75.69% (109/144) referring to MFI, respectively. Vascular architecture type IV and V in CDFI was significantly lower than SMI (x2 = 18.217, P < 0.001) and MFI (x2 = 29.518, P < 0.001). Whereas there was no significant difference between SMI and MFI (x2 = 3.048, P = 0.550). The sensitivity and specificity of CDFI, SMI and MFI in the diagnosis of renal mass were 61.29% and 90.20%, 79.57% and 88.24%, 88.17% and 84.31% respectively. The areas under the ROC curve of the three were 0.757, 0.839 and 0.862, respectively. There was a statistically significant difference between CDFI and MFI (Z = 3.687, P = 0.0002), while there was no statistically significant difference between SMI and MFI (Z = 1.167, P = 0.2431).

Conclusion
SMI and MFI are superior to CDFI in showing blood flow signals in renal solid masses, and it can perform blood flow and vascular architecture more accurately.

Advances in knowledge
SMI is similar to MFI in its ability to display fine vessels and diagnostic efficiency, and has application value in the diagnosis and differential diagnosis of renal solid masses.
Information presentation method for teleoperated robots to support the multifaceted understanding of fire sites
Authors: Tamura Yoshihiro , Amano Hisanori , Ota Jun 
Published: May 2022

AbstractAlthough the overall number of fires is decreasing, the number of special fires as buildings become larger, taller, and deeper and fires and spills in hazardous materials facilities such as petroleum complexes is on the rise and ensuring the safety of firefighters has become a problem. The use of teleoperated firefighting robots is expected to be a solution to this problem. It is important to be able to operate the robot well, recognize the environment, and make decisions on what actions to take to perform the firefighting more effectively. This is closely related to the design of human machine interface (HMI) for teleoperated robots, but much of the research on HMI for teleoperated robots is concerned with how to operate the robot and how to present the information that is needed for operation. In addition, as the overall number of fires is decreasing, young firefighters' (novices’) lack of experience in firefighting has become a problem. Therefore, teleoperated firefighting robots are required to have the HMI that enables supports to recognize the environment and make decisions in firefighting. This study presents an information presentation method that is based on the control mode in the contextual control model (COCOM) to ensure that novices can have multifaceted perspectives during reconnaissance and attenuation like experienced firefighters (experts). The effectiveness of this method is confirmed by 12 firefighters. As a result, this study confirms that the information presentation is designed considering the control mode in the COCOM, and it improves the score from multiple perspectives. The findings of this study will contribute to the future development of teleoperated firefighting robots.
3D printed anthropomorphic left ventricular myocardial phantom for nuclear medicine imaging applications
Authors: Kiss Janos , Balkay Laszlo , Kukuts Kornel , Miko Marton , Forgacs Attila , Trencsenyi Gyorgy , Krizsan Aron K. 
Published: May 2022

Abstract
Background
Anthropomorphic torso phantoms, including a cardiac insert, are frequently used to investigate the imaging performance of SPECT and PET systems. These phantom solutions are generally featuring a simple anatomical representation of the heart. 3D printing technology paves the way to create cardiac phantoms with more complex volume definition. This study aimed to describe how a fillable left ventricular myocardium (LVm) phantom can be manufactured using geometry extracted from a patient image.

Methods
The LVm of a healthy subject was segmented from 18F-FDG attenuation corrected PET image set. Two types of phantoms were created and 3D printed using polyethylene terephthalate glycol (PETG) material: one representing the original healthy LVm, and the other mimicking myocardium with a perfusion defect. The accuracy of the LVm phantom production was investigated by high-resolution CT scanning of 3 identical replicas. 99mTc SPECT acquisitions using local cardiac protocol were performed, without additional scattering media (“in air” measurements) for both phantom types. Furthermore, the healthy LVm phantom was inserted in the commercially available DataSpectrum Anthropomorphic Torso Phantom (“in torso” measurement) and measured with hot background and hot liver insert.

Results
Phantoms were easy to fill without any air-bubbles or leakage, were found to be reproducible and fully compatible with the torso phantom. Seventeen segments polar map analysis of the "in air” measurements revealed that a significant deficit in the distribution appeared where it was expected. 59% of polar map segments had less than 5% deviation for the "in torso” and "in air” measurement comparison. Excluding the deficit area, neither comparison had more than a 12.4% deviation. All the three polar maps showed similar apex and apical region values for all configurations.

Conclusions
Fillable anthropomorphic 3D printed phantom of LVm can be produced with high precision and reproducibility. The 3D printed LVm phantoms were found to be suitable for SPECT image quality tests during different imaging scenarios. The flexibility of the 3D printing process presented in this study provides scalable and anthropomorphic image quality phantoms in nuclear cardiology imaging.
Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET
Authors: Rossano Samantha , Toyonaga Takuya , Bini Jason , Nabulsi Nabeel , Ropchan Jim , Cai Zhengxin , Huang Yiyun , Carson Richard E. 
Published: May 2022

Abstract
Purpose
Neuronal damage and synapse loss in the spinal cord (SC) have been implicated in spinal cord injury (SCI) and neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS). Current standards of diagnosis for SCI include CT or MRI imaging to evaluate injury severity. The current study explores the use of PET imaging with [11C]UCB-J, which targets the synaptic vesicle protein 2A (SV2A), in the human spinal cord, as a way to visualize synaptic density and integrity in vivo.

Results
First, simulations of baseline and blocking [11C]UCB-J HRRT scans were performed, based on SC dimensions and SV2A distribution to predict VT, VND, and VS values. Next, human baseline and blocking [11C]UCB-J HRRT images were used to estimate these values in the cervical SC (cSC). Simulation results had excellent agreement with observed values of VT, VND, and VS from the real human data, with baseline VT, VND, and VS of 3.07, 2.15, and 0.92 mL/cm3, respectively, with a BPND of 0.43. Lastly, we explored full SC imaging with whole-body images. Using automated SC regions of interest (ROIs) for the full SC, cSC, and thoracic SC (tSC), the distribution volume ratio (DVR) was estimated using the brain gray matter as a reference region to evaluate SC SV2A density relative to the brain. In full body imaging, DVR values of full SC, cSC, and tSC were 0.115, 0.145, and 0.112, respectively. Therefore, measured [11C]UCB-J uptake, and thus SV2A density, is much lower in the SC than in the brain.

Conclusions
The results presented here provide evidence for the feasibility of SV2A PET imaging in the human SC, however, specific binding of [11C]UCB-J is low. Ongoing and future work include further classification of SV2A distribution in the SC as well as exploring higher-affinity PET radioligands for SC imaging.
A case report of adenosquamous carcinoma of the esophagogastric junction
Authors: Fukai Harunari , Koide Naohiko , Yanagisawa Naoe , Koyama Yoshinori , Kitagawa Nami , Ogihara Yuu , Ohya Maki 
Published: May 2022

Abstract
Background
Many types of tumors can arise in the esophagogastric junction (EGJ). Squamous cell carcinoma (SCC) arising from the esophageal epithelia, adenocarcinoma arising from the gastric mucosa, or Barrett’s esophageal mucosa are frequently observed in the EGJ. However, adenosquamous carcinoma (ASC) has been rarely observed in this area. We herein report a rare case of ASC of the EGJ.

Case presentation
An 81-year-old man visited our hospital complaining of dysphagia. Esophagogastroduodenoscopy detected an elevated tumor in the gastric cardia. Biopsy specimens taken from the tumor showed SCC. Computed tomography revealed a tumor located in the EGJ and node metastases surrounding the EGJ. The tumor was diagnosed as SCC, overhanging in the stomach, of the EGJ. The patient underwent a proximal gastrectomy with a lower esophagectomy and node dissection for the metastases surrounding the EGJ, and esophagogastrostomy in the lower mediastinum. Histopathologic examination showed the tumor consisted of SCC and adenocarcinoma. The adenocarcinoma consisted of nests scattered in the SCC. We observed adenocarcinoma component in 35% of the tumor and epithelial spread of SCC in the lower esophagus. Thus, we diagnosed the tumor as ASC of the EGJ. Eight metastatic nodes were dissected; both SCC and adenocarcinoma were observed in seven.

Conclusions
In the present case, SCC may be originated from the squamous epithelia of the lower esophagus and grew into the stomach, and the adenocarcinoma may have differentiated from SCC through the infiltration.
Psoriatic arthritis mutilans: a descriptive study from a Brazilian tertiary center
Authors: Cordeiro Rafael Alves , de Oliveira Jobson Lopes , Sampaio-Barros Percival Degrava , Goldenstein-Schainberg Claudia 
Published: May 2022

AbstractIn this paper, we sought to determine the prevalence of arthritis mutilans in a single cohort of Brazilian psoriatic arthritis patients followed at a tertiary university reference center. Our study demonstrated a high prevalence of arthritis mutilans associated to comorbidities and biologic therapy. In addition, our data suggest that axial involvement may be an intriguing aspect of psoriatic arthritis mutilans and that rheumatologists should be aware of axial disease, even if the phenotype is marked by peripheral joint severity.
16O + 16O cluster states and their fusion to 32S: A non-monotonic potential description
Authors: Basak A. K. , Merchant A. C. , Freer M. , Islam M. Sujan , Ramon Ragib Absar , Rahman M. Mizanur , Tariq A. S. B. , Uddin M. A. , Soylu A. 
Published: May 2022

Abstract
Non-monotonic (NM) nucleus-nucleus potential families rooted in the Pauli-compliant Energy Density Functional (EDF) theory and especially their behavior at higher energies have been investigated using experimental data for 16O + 16O elastic scattering in the range

. At

, the 16O + 16O NM potentials in a simple optical model (OM) are found to support five rotational bands of 16O + 16O bound and quasi-molecular states in 32S with the cluster global quantum numbers G = 24, 26, 28, 30 and 32. The lowest band in the experimental spectrum starting at

, and having

, 2+, 4+, 6+ and 8+, has been located for the first time. In the simple OM, the NM potentials are found to reproduce the experimental 16O + 16O fusion cross-sections in the energy range 12–31 MeV. The present work shows that both the 16O + 16O cluster bands and fusion cross-sections in the Coulomb barrier region can be reproduced using NM potentials.
Modern data on embryogenesis and functional morphology of thymus (Literature review, part I)
Authors: Kupriianova L. , Ivanchenko S. 
Published: May 2022

In the following article we have provided modern data on main stages of implementation, formation as well as stabilization of functional activity of thymus of the fetus on different stages of fetal development. Thus, we have analyzed specific features of gland’s location in case of children, adolescents and adults. We have described two main stages of the organ’s ontogenesis. In addition, histological features of the fetal thymus implemetation, starting with the 8th week of embryonic development were studied and provided below. The criteria of completion of the gland’s formation on the gestational term of 24 weeks were clearly emphasized. The stages of maturing of lymphocytes as well as appearance of the surface markers of the lymphocytes on them as well as division of the T-cells into subpopulations were described. The role of thymus in the sphere of formation of all types of the organism’s immune defence was explained. We have analyzed an endocrine function of the gland with providing the hormones, hormone-like substances, as well as extracts of the organ, which have their influence onto lymphoid tissue development as well as play their leading role in the hormonal homeostasis of the child’s organism. The morphological features of the main structural components of the gland, as well as their functions in the thymus stabilization were disclosed. The nature of relations between structural components was clearly described. It has been proved also, that in case of full-term fetus, the thymus is a main lymphoid organ, which is structurally and functionally formed for the moment of birth. Moreover, under the conditions of the physiological pregnancy the lymphoid and epithelial components are sufficiently and harmoniously developed, and the thymocytes are differentiated and immunologically mature. Finally, we came up with the conclusion, that the pathology of pregnancy and childbirth can lead to the impaired embryogenesis and fetogenesis of the fetal thymus.