bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discrimination of sweet‐fat ingredients in people with weight‐ and eating‐related problems using a signal detection theory
Authors: Garcia‐Burgos David , Andres Fabienne , Trier Stephan , Vögele Claus , Munsch Simone 
Published: August 2022

AbstractIndividuals with impaired gustatory perception may have altered ingestive behaviors, which contribute to unhealthy weight status and disordered eating. Whether and to what extent weight status or eating symptomatology depend on flavor perception is still a controversial issue. Thus, the ability to discriminate among different levels of sweetness/fat content was compared in three studies using two‐alternative forced‐choice tasks and the standardized metrics of signal detection theory (SDT). In Study 1, three body mass index groups were included: underweight, healthy normal weight, and overweight. In Study 2, volunteers were currently‐ill and recovered (anorexia/bulimia nervosa) patients, and two age‐ and weight‐matched control groups. In Study 3, SDT metrics of both populations were compared. Results showed that SDT measures identified difficulties of underweight individuals to discriminate fat levels in sugary products, while patients with eating disorders exhibited outstanding discrimination of fat ingredients. Judgment biases were also detected in both populations. This highlights importance of using SDT methodology in flavor perception research in people with weight−/eating‐related problems.Practical ApplicationsThis paper may serve as a starting point for the establishment of a consensual methodology in the field of flavor perception using the SDT approach. Especially in populations with eating‐ and weight‐related problems, it is both of considerable interest and a necessity to establish and promote standard metrics to provide more consistent and comparable results on the perception of sweet and fat inputs. On the one hand, SDT may be a valuable tool to deal with current methodological limitations and heterogeneity in methods used across studies. On the other, this should facilitate further study of the relationship between oral sensations and unhealthy eating and drinking behaviors to improve individuals' nutritional status and quality of life.
Physical activity among young children with disabilities: a systematic review protocol
Authors: Vanderloo Leigh M , Taylor Leah , Yates Julia , Bassett-Gunter Rebecca , Stanley Meagan , Tucker Patricia 
Published: August 2022

IntroductionPhysical activity in the early years is necessary for setting the foundation for healthy growth and development in later childhood and adolescence. While most published evidence to date focuses on typically developing children, prevalence rates of physical activity among children with disabilities have been less studied. This protocol paper documents the plan of a systematic review, which aims to synthesise the evidence regarding physical activity levels among young children with disabilities.Methods and analysisSearches are anticipated to commence in May 2022. Empirical quantitative studies will be considered for inclusion if they present intervention or observational data on non-therapeutic (ie, leisure time) physical activity among children <5.99 years with physical, mental, intellectual or sensory impairments. Data sources will be retrieved via electronic database searches (Cumulative Index to Nursing and Allied Health Literature (CINAHL), EBSCO Sports Medicine Database (SPORTDiscus), Medical Literature Analysis and Retrieval System Online (MEDLINE), Elsevier Bibliographic Database (Scopus), Psychological Abstracts (PsycINFO), Education Resources Information Centre (ERIC) and Excerpta Medica Database (EMBASE)). Additional strategies to identify relevant studies will include manual searching and citation tracking of included articles. Titles and abstracts of identified studies will be screened for inclusion, followed by full-text reviews. Three independent reviewers will conduct quality appraisal using the Downs and Black checklist. A summary of included studies will describe the study designs, participant and activity characteristics, and outcomes.Ethics and disseminationThis systematic review involves a secondary analysis of previously published data; therefore, this review does not require ethical approval. The proposed paper will summarise the current evidence base on physical activity levels among young children with a diagnosed disability. The findings from this systematic review will identify gaps to be explored by future research studies and inform future investigations among the paediatric disability population.PROSPERO registration numberCRD42021266585.
Multilevel analysis of grand multiparity: Trend and its determinants in the Sidama National Regional State of Ethiopia: a cross-sectional study design from demographic and health survey 2000–2016
Authors: Dasa Tamirat Tesfaye , Okunlola Michael A , Dessie Yadeta 
Published: August 2022

ObjectiveThe study was aimed at examining the magnitude, trends and determinants of grand multiparity in the Sidama regional state of Ethiopia.DesignWe retrieved cross-sectional data from the Ethiopia Demographic and Health Survey from 2000 to 2016.SettingCommunity-based demographic and health survey (DHS) was conducted in Ethiopia.ParticipantsThe study population was women (aged 15–49 years) who had delivered children with the available DHS data set.OutcomesMultilevel multivariate logistic regression analyses assessed the relationship between grand multiparity and its determinants.ResultsThe magnitude of grand multiparity was 70.8% (95% CI 68.5% to 72.9%). The multilevel multivariable logistic regression model showed illiteracy (adjusted OR (AOR)=2; 95% CI 1.25 to 3.75), non-use of any contraceptive (AOR=3.8; 95% CI 1.2 to 12.2), early marriage (AOR=4.5; 95% CI 2.6 to 7.9), polygamous marriage (AOR=4.2; 95% CI 2.0 to 9.3), short birth intervals (AOR=2.3; 95% CI 1.4 to 3.5) and husband’s low education status (AOR=5.8; 95% CI 2.1 to 16.1) were significantly associated with grand multiparity.ConclusionsThis study revealed that 7 of 10 women were grand multipara, and the magnitude did not show significant change over the last 16 years. Early marriage and early age at first birth, low literacy level, low family planning utilisation, polygamy, short interbirth interval and unmet need for family planning were determinants of grand multiparity. We recommended the stakeholders to design new strategies to address the root cause of high fertility factors in communities.
Approaches to the development of new mental well-being screening tools for Indigenous peoples: a systematic mixed studies review protocol
Authors: Meldrum Kathryn , Andersson Ellaina , Wallace Valda , Webb Torres , Quigley Rachel , Strivens Edward , Russell Sarah 
Published: August 2022

IntroductionIndigenous peoples' world views are intricately interrelated and interconnected with those of their communities and the environments where they live. Consequently, Indigenous peoples have a holistic view of their health, which contrasts with the dominant Western biomedical paradigm. However, the mental well-being of Indigenous peoples is predominately screened using tools developed using the Western paradigm that may not be culturally appropriate. The objective of this systematic mixed studies review (SMSR) is to assess the extent of the literature related to approaches used to develop new tools to screen the mental well-being of Indigenous adults.Methods and analysisThis SMSR will be conducted in accordance with the method proposed by Pluye et al. It will include studies that describe the development of any type of tool or approach to screen for mental well-being in Indigenous adults, globally. Searches will be limited to the English language and literature published since January 2000. Databases to be searched include: CINAHL, Medline, PsycINFO, PubMed and Scopus. Only published studies will be included in the SMSR. Data that answers the research questions will be extracted from the literature and recorded on the associated data charting form. A sequential synthesis method will be used to analyse data from qualitative, quantitative and mixed-method studies. Data will be presented graphically, diagrammatically or in tabular form depending on what approach best conveys its meaning.Ethics and disseminationThe SMSR will describe the approach to developing new tools for screening the mental well-being of Indigenous peoples across the globe. It will support researchers, clinicians and practitioners to consider both their approach to new tool development or, if they are using a previously developed tool, how reliable and valid it is for the population that they intend to use it with. Peer-reviewed publications will be used to disseminate SMSR findings.
Speculative Realism and Religion: Irreduction, Objects, Forms, and Intensities
Authors: MacKay Michael Hubbard 
Published: August 2022

Abstract
This article uses the philosophy of Tristan Garcia to theorize about religion and to identify religion as an object without essentializing it (scientistic reduction) or reducing it to culture (as in critical theory). It proposes a radical speculative ontology for analyzing religion in opposition to late-liberalism’s determining effects on the study of religion. In juxtaposition with Graham Harman’s object-oriented ontology and Quentin Meillassoux’s speculative philosophy, Garcia’s philosophy offers a unique perspective about the irreduction of religion and classification within religious studies, especially through his philosophy of intensities. His perspective on the concatenation of human and nonhuman objects and their assemblages compliments and builds upon the current scholarship in material religion. In particular, his philosophy of intensities enables religion and religions to be dispersed into countless temporal instances and evaluated in limitless levels of intensity in a classificatory system set to avoid reductionism and neoliberalism.
Validation of vital sign measurement by nanosecond pulse near-field sensing and the conductive silver paste printed textile technique
Authors: Chen Kuan-Hung , Chen Yong-Syuan , Chen Chih-Lung , Yang Ching-Yi , Yang Chiau-ling , Yang Fu-Cheng , Liu Chia-Hao , Huang Shu-Chun 
Published: August 2022

Vital sign monitoring is fundamental in daily patient care. Wearable technology has become an important tool in personalized medicine; however, there is a tradeoff problem between accuracy and comfort caused by the elastic textile used. Our study sought to examine the accuracy of heart rate (HR) and breathing rate (BR) monitoring as measured by iSmartweaR, a novel wearable and wireless sensor that uses the laser Doppler technique, with special focus on sex and different static postures. A total of 30 male and 23 female patients, including 23 patients with cardiovascular diseases and 30 healthy participants, were recruited. The HR and BR were measured with iSmartweaR and the gold standard method (CardioSoft and MasterScreen™ CPX) simultaneously in three static postures (supine rest, right lateral decubitus, and left lateral decubitus). The mean errors of HR and BR between iSmartweaR and the gold standard method were close to zero (0.55 and 0.71, respectively). The standard deviations of the HR error and BR error were 0.59 and 0.67, respectively. Disease, posture, sex, and measurement time did not cause clinically significant measurement errors. The overall percentage of missing data was 7.01%. The use of iSmartweaR was valid across different sexes and static postures. It is real-time, continuous and manpower-saving, and can be applied in patient care.
Protective effects of pentoxifylline on T-cell viability under inflammatory conditions
Authors: Park Sung-Joon , Choi Sung-Hyuk , Cho Young-Duck , Kim Jung-Youn , Cho Han-Jin , Kim Kyung-Hwan , Kim Won-Young 
Published: August 2022

Introduction: Pentoxifylline (PTX) reduces the levels of pro-inflammatory cytokines; however, its effects on immune system is not well understood. The aim of this study was to investigate the effect of PTX on T cells under inflammatory conditions in co-culture with THP-1-derived macrophages. Methods: Toll-like receptor 4 (TLR4) and macrophage migration inhibitory factor (MIF) levels were measured after addition of PTX to lipopolysaccharide (LPS)-stimulated differentiated THP-1 cells. T cell viability and MIF levels were measured after PTX was added to prostaglandin E2 (PGE2)-stimulated Jurkat T-cell leukemia line. Co-culture was conducted to determine the effect of LPS-stimulated differentiated THP-1 cells that are affected by PTX on Jurkat cells. To prevent the direct effects of LPS and PTX on Jurkat cells, LPS and PTX were washed from THP-1 cells before co-culture. T cell viability and interleukin-2 (IL-2) levels were determined in Jurkat cells. Results: Increase in the MIF concentration and TLR4 expression level in differentiated THP-1 cells stimulated with LPS were reversed after PTX addition. However, PTX did not improve T cell viability in PGE2–stimulated Jurkat cells. Co-culturing Jurkat cell and LPS-stimulated differentiated THP-1 cells resulted in a decreased viability of T cells. The addition of PTX restored T cell viability to normal control levels and IL-2 expression level in Jurkat cells. Conclusion: LPS-stimulated THP-1-derived macrophages reduced the T cell viability under inflammation. However, PTX restored T cells viability and IL-2 back to normal levels. Therefore, the immunomodulatory action of PTX may be mediated by macrophage-T cell interactions.
A National Cancer Database Analysis of Sinonasal Malignant Myoepithelial Carcinoma Outcomes
Authors: Eide Jacob G. , Kshirsagar Rijul S. , Brant Jason A. , Palmer James N. , Adappa Nithin D. 
Published: August 2022

Objectives Myoepithelial carcinoma (MECA) is a rare salivary gland tumor that can occur in the sinonasal cavity with poor outcomes. There are limited data on sinonasal outcomes to guide management. We sought to use the National Cancer Database (NCDB) to better define treatment outcomes in MECA. Methods We conducted a retrospective analysis of the NCDB from 2004 to 2016 for patients with MECA of the sinonasal cavity. Patient demographic, treatment, and survival information were extracted from the database. Unadjusted Kaplan–Meier estimates, log-rank tests, and a multivariable Cox proportional hazard model were used to assess overall survival (OS). Results A total of 38 patients were included. The average age was 60.7 ± 18.2 years and male patients represented 47.4% of the cohort. Most patients were White (n = 26, 68.4%) and the majority of patients had either private insurance (n = 20, 52.6%) or Medicare (n = 15, 39.5%). The primary site of most tumors was nasal cavity (n = 19, 50%), followed by maxillary sinus (n = 16, 42.1%). Most tumors were >4 cm (n = 17, 44.7%). The 1-, 5-, and 10-year OS was 89.7% (95% confidence interval [CI]: 80.7%−99.8%), 63.6% (95% CI: 49.4%−82%), and 46.4% (95% CI: 31%−69.5%), respectively. The median survival for the overall cohort was 85.8 months. Medicare insurance was associated with a decreased OS (hazard ratio [HR]: 8.2; 95% CI: 2.88−23.4, P < .001). Patients who underwent surgery had a significant survival benefit (HR: 0.04, 95% CI: 0.01−0.21, P < .001). Discussion MECA of the sinonasal cavity is a rare tumor with poorly understood behavior. Data from the NCDB suggests that it is a relatively aggressive tumor with surgical management associated with better outcomes. This analysis is limited by the small sample size and further research into optimal treatment regimens is needed.
Nutrition vs association: plant defenses are altered by arbuscular mycorrhizal fungi association not by nutritional provisioning alone
Authors: Stratton Chase A. , Ray Swayamjit , Bradley Brosi A. , Kaye Jason P. , Ali Jared G. , Murrell Ebony G. 
Published: August 2022

Abstract
Background
While it is known that arbuscular mycorrhizal fungi (AMF) can improve nutrient acquisition and herbivore resistance in crops, the mechanisms by which AMF influence plant defense remain unknown. Plants respond to herbivory with a cascade of gene expression and phytochemical biosynthesis. Given that the production of defensive phytochemicals requires nutrients, a commonly invoked hypothesis is that the improvement to plant defense when grown with AMF is simply due to an increased availability of nutrients. An alternative hypothesis is that the AMF effect on herbivory is due to changes in plant defense gene expression that are not simply due to nutrient availability. In this study, we tested whether changes in plant defenses are regulated by nutritional provisioning alone or the response of plant to AMF associations. Maize plants grown with or without AMF and with one of three fertilizer treatments (standard, 2 × nitrogen, or 2 × phosphorous) were infested with fall armyworm (Spodoptera frugiperda; FAW) for 72 h. We measured general plant characteristics (e.g. height, number of leaves), relative gene expression (rtPCR) of three defensive genes (lox3, mpi, and pr5), total plant N and P nutrient content, and change in FAW mass per plant.

Results
We found that AMF drove the defense response of maize by increasing the expression of mpi and pr5. Furthermore, while AMF increased the total phosphorous content of maize it had no impact on maize nitrogen. Fertilization alone did not alter upregulation of any of the 3 induced defense genes tested, suggesting the mechanism through which AMF upregulate defenses is not solely via increased N or P plant nutrition.

Conclusion
This work supports that maize defense may be optimized by AMF associations alone, reducing the need for artificial inputs when managing FAW.
Left ventricular myocardial mass index associated with cardiovascular and renal prognosis in IgA nephropathy
Authors: Sági Balázs , Késői István , Vas Tibor , Csiky Botond , Nagy Judit , Kovács Tibor József 
Published: August 2022

Abstract
Introduction
In chronic kidney disease (CKD), like in IgA nephropathy (IgAN), cardiovascular (CV) mortality and morbidity are many times higher than in the general population, and left ventricular hypertrophy (LVH) is an independent risk factor for CV disease. This follow-up study investigated the association between left ventricular mass index (LVMI) and renal or cardiovascular outcomes.

Methods
We examined 118 IgAN patients prospectively. LVMI and LV geometry was investigated using echocardiography. The primary combined endpoints were total mortality, major CV events, and end-stage renal disease. Secondary endpoints, i.e.—cardiovascular or renal endpoints,—were also examined separately.

Results
Sixty seven percent were males, mean age 53.5 ± 13.5. Mean follow-up time: 184 months. LVMI inversely correlated with eGFR (corr. coefficient: -0.365; p < 0.01). We divided the patients into two groups based on the LVMI cut-off suggested by the literature. The presence of LVH caused a worse prognosis in primary (p < 0.001), renal endpoints (p = 0.01), and also in CV endpoints (p = 0.001). The higher LVMI in men significantly worsened the prognosis in all endpoints. Concentric hypertrophy meant a worse prognosis. Independent predictors of LVMI were gender and eGFR in uni- and multivariate regression and hemoglobin levels only in logistic regression. Independent predictors of the primary endpoint were LVMI, eGFR, gender, obesity, HT, DM, and metabolic syndrome in Cox regression analysis.

Conclusion
Increased LVMI may predict the progression to end-stage renal disease and CV events in IgAN. Determining LVMI may be a useful parameter not only in CV risk but also in the stratification of renal risk in CKD.
Outcomes of allogeneic haematopoietic stem cell transplantation for paediatric patients with MLL-rearranged acute myeloid leukaemia
Authors: Bai Lu , Zhang Yong-zhan , Yan Chen-hua , Wang Yu , Xu Lan-ping , Zhang Xiao-hui , Zhang Le-ping , Huang Xiao-jun , Cheng Yi-fei 
Published: August 2022

Abstract
Background
The presence of mixed-lineage leukaemia rearrangement (MLL-r) in paediatric patients with acute myeloid leukaemia (AML) is a poor prognostic predictor. Whether allogeneic haematopoietic stem cell transplantation (allo-HSCT) is beneficial in such cases remains unclear.

Methods
We evaluated the outcomes and prognostic factors of allo-HSCT in 44 paediatric patients with MLL-r AML in the first complete remission (CR1) between 2014 and 2019 at our institution.

Results
For all the 44 patients, the 3-year overall survival (OS), event-free survival (EFS), and cumulative incidence of relapse (CIR) were 74.5%, 64.1%, and 29.1%, respectively. Among them, 37 (84.1%) patients received haploidentical (haplo)-HSCT, and the 3-year OS, EFS, and CIR were 73.0%, 65.6%, and 26.4%, respectively. The 100-day cumulative incidence of grade II–IV acute graft-versus-host disease (aGVHD) post-transplantation was 27.3%, and that of grade III–IV aGVHD was 15.9%. The overall 3-year cumulative incidence of chronic graft-versus-host disease (cGVHD) post-transplantation was 40.8%, and that of extensive cGVHD was 16.7%. Minimal residual disease (MRD)-positive (MRD +) status pre-HSCT was significantly associated with lower survival and higher risk of relapse. The 3-year OS, EFS, and CIR differed significantly between patients with MRD + pre-HSCT (n = 15; 48.5%, 34.3% and 59%) and those with MRD-pre-HSCT (n = 29; 89.7%, 81.4% and 11.7%). Pre-HSCT MRD + status was an independent risk factor in multivariate analysis.

Conclusions
Allo-HSCT (especially haplo-HSCT) can be a viable strategy in these patients, and pre-HSCT MRD status significantly affected the outcomes.
Prevalence of reduced visual acuity among adolescents in Jiaocheng County, Shanxi Province
Authors: Yang Yang , Li Chunhui , Gao Yan 
Published: August 2022

AbstractPurposeTo investigate the prevalence of reduced visual acuity among adolescents in Jiaocheng County, Shanxi Province.MethodsFourteen thousand fifty-one Jiaocheng County students aged 7 to 21 were chosen to engage in this research project in 2019. For uncorrected distance visual acuity (UCDVA) testing, a 5 m standard logarithmic visual sharpness E chart was utilized, and for diopter examination of those with reduced UCDVA, computerized optometry was used. The factors linked to reduced UCDVA in students were investigated using logistic regression analysis.ResultsIn Jiaocheng County, Shanxi Province, the prevalence of reduced UCDVA among adolescents was 77.54% in 2019, with the highest rate of severely reduced UCDVA at 47.58% and myopia accounting for the highest proportion of reduced UCDVA, with myopia rates above 90% in all age groups. Girls, those who live in counties, those who are anxious about their studies, and those who dedicate more time to schoolwork are more prone to suffer from a decrease in UCDVA; those who spend more time outdoors and get adequate sleep are less likely to have reduced UCDVA, according to logistic regression analysis.ConclusionAdolescents in Jiaocheng County, Shanxi Province, have a high prevalence of reduced UCDVA, and interventions targeting key populations should be increased based on effective prevention and control of reduced UCDVA among local adolescents.