bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic Risks Are Increasing in Non-B Non-C Early-Stage Hepatocellular Carcinoma: A 10-Year Follow-Up Study
Authors: Lin Yen-Po , Wang Pei-Ming , Chuang Ching-Hui , Yong Chee-Chen , Liu Yueh-Wei , Huang Pao-Yuan , Yao Chih-Chien , Tsai Ming-Chao 
Published: February 2022

BackgroundNon-B, non-C hepatocellular carcinoma (NBNC-HCC) may be related to metabolic syndrome, and the incidence of this tumor type is increasing annually. The definition of metabolic-associated fatty liver disease (MAFLD) proposed in 2020 may help to more accuratelyassess the association between metabolic syndrome and NBNC-HCC. However, this new concept has not yet been applied in NBNC-HCC research. Therefore, this study aimed to compare the clinicopathological characteristics of patients with NBNC-HCC and CHB-HCC diagnosed between 2009-13 and 2014-18, focusing on metabolic risk factors and the new concept of MAFLD.MethodPatients with BCLC-0/A-HCC who received curative hepatectomy between January 2009 and December 2018 were retrospectively assessed; the associations between clinicopathological characteristics and clinical outcomes of NBNC-HCC and CHB-HCC were analyzed by multivariate analysis.ResultCompared to patients diagnosed in 2009-13, the frequency of metabolic disorders in NBNC-HCC was significantly higher in 2014-18 [DM (p=0.049), HTN (p=0.004), BMI (p=0.017) and MAFLD (p=0.003)]; there was no significant change in patients with CHB-HCC. Moreover, CHB-HCC was an independent risk factor for HCC recurrence (HR, 1.339; 95% CI, 1.010-1.775, p=0.043) and death (HR, 1.700; 95% CI, 1.017-2.842, p=0.043) compared to NBNC-HCC.ConclusionsTherisk of MAFLD, obesity, DM, and hypertension in patients with early-stage NBNC have significantly increased in recent years, thus metabolic syndrome should be monitored in this special population. Moreover, NBNC-HCC tend to had a better prognosis than CHB-HCC, probably due to their distinct clinicopathological features.
Ultrasound-Guided Comparison of Psoas Compartment Block and Supra-Inguinal Fascia Iliaca Compartment Block for Pain Management in Pediatric Developmental Dysplasia of Hip Surgeries
Authors: Quan Junjun , Yang Shujun , Chen Yuchao , Chen Kai , Yu Siyuan 
Published: February 2022

BackgroundThe aim of this study was to compare psoas compartment block (PCB) and supra-inguinal fascia iliaca compartment block (SFIB) in terms of pain management and the need for additional systemic analgesia in the perioperative phase of developmental dysplasia of the hip (DDH).Materials and MethodsSixty pediatric patients were randomized into the PCB group and the SFIB group. The Numeric Rating Scale (NRS) pain scores were used to assess postoperative pain during the initial 24 h after extubation. Sufentanil consumption, patient-controlled analgesia (PCA) demands, and complications were also recorded.ResultsThe NRS pain scores were significantly lower in the PCB group than in the SFIB group at 0, 4, 8, 12, and 24 h after extubation (all P &lt; 0.01). Postoperatively, 13.8% of patients in the PCB cohort received additional administration of sufentanil, in contrast to 63.3% of the SFIB cohort (P &lt; 0.01). In the PCB group, 0 (0-0) mcg/kg sufentanil was administered, while in the SFIB group 0.1 (0-0.2) mcg/kg (P &lt; 0.01). In addition, the PCB group had fewer PCA demands than the SFIB group within the initial 24 h (P &lt; 0.01). It took less operating time to achieve SFIB as compared to PCB (P &lt; 0.01). No adverse events related to two techniques were recorded.ConclusionsPCB provided a better perioperative pain management in pediatric patients with the DDH surgeries compared to SFIB. It also reduced the need for supplementary systemic analgesia.
Beneficial Effects of Silybin Treatment After Viral Eradication in Patients With HCV-Related Advanced Chronic Liver Disease: A Pilot Study
Authors: Cossiga Valentina , Sanduzzi-Zamparelli Marco , Sapena Victor , Guarino Maria , Dallio Marcello , Torrisi Emanuele , Pignata Luca , Federico Alessandro , Salomone Federico , Morisco Filomena 
Published: February 2022

Introduction and Aims: HCV eradication by direct-acting antivirals (DAAs) improves liver outcomes and reduces overall liver mortality. However, patients with advanced chronic liver disease (ACLD) may experience a progression of liver disease despite viral clearance. Silybin has shown hepatoprotective effects in experimental models, but clinical data are limited. The aim of this study is to evaluate the effect of a highly bioavailable form of silybin on liver fibrosis in patients with HCV-related ACLD after viral eradication with DAAs, in comparison with the standard of care.Methods: In this multicenter and prospective study, HCV patients with ACLD achieving SVR12 were treated with the combination of silybinphospholipid complex with vitamin D and vitamin E (Realsil 100D®, Ibi Lorenzini S.p.A., Aprilia, Italy) for 12 months (R group) compared to controls (C group). Patients were submitted to transient elastography (TE) and to the enhanced liver fibrosis (ELF) test at baseline, week 24, and week 48.Results: One hundred sixteen patients were enrolled, 56 in the R group and 60 in the C group. The median age was 68 years, and 53% were male, with no differences between groups. In both groups, liver stiffness improved at 6 and 12 months compared to baseline. However, patients in the R group compared to those in the C group showed a higher reduction of liver stiffness after 6 months (−2.05, 95% CI −3.89 to −0.22, p &lt; 0.05) and 12 months of treatment (−2.79, 95% CI −4.5 to −1.09, p &lt; 0.01) in comparison with baseline. No significant difference in the reduction of ELF was observed between the two groups. During the follow-up, four patients developed HCC, all in the C group.Conclusions: In HCV-related ACLD, the hepatoprotective effects of silybin may represent a tool to counteract liver disease progression.
The Treatment With the SGLT2 Inhibitor Empagliflozin Modifies the Hepatic Metabolome of Male Zucker Diabetic Fatty Rats Towards a Protective Profile
Authors: Aragón-Herrera Alana , Otero-Santiago Manuel , Anido-Varela Laura , Moraña-Fernández Sandra , Campos-Toimil Manuel , García-Caballero Tomás , Barral Luis , Tarazón Estefanía , Roselló-Lletí Esther , Portolés Manuel , Gualillo Oreste , Moscoso Isabel , Lage Ricardo , González-Juanatey José Ramón , Feijóo-Bandín Sandra , Lago Francisca 
Published: February 2022

The EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial in patients with Type 2 Diabetes Mellitus (T2DM)) trial evidenced the potential of sodium-glucose cotransporter 2 (SGLT2) inhibitors for the treatment of patients with diabetes and cardiovascular disease. Recent evidences have shown the benefits of the SGLT2 inhibitor empagliflozin on improving liver steatosis and fibrosis in patients with T2DM. Metabolomic studies have been shown to be very useful to improve the understanding of liver pathophysiology during the development and progression of metabolic hepatic diseases, and because the effects of empagliflozin and of other SGLT2 inhibitors on the complete metabolic profile of the liver has never been analysed before, we decided to study the impact on the liver of male Zucker diabetic fatty (ZDF) rats of a treatment for 6 weeks with empagliflozin using an untargeted metabolomics approach, with the purpose to help to clarify the benefits of the use of empagliflozin at hepatic level. We found that empagliflozin is able to change the hepatic lipidome towards a protective profile, through an increase of monounsaturated and polyunsaturated glycerides, phosphatidylcholines, phosphatidylethanolamines, lysophosphatidylinositols and lysophosphatidylcholines. Empagliflozin also induces a decrease in the levels of the markers of inflammation IL-6, chemerin and chemerin receptor in the liver. Our results provide new evidences regarding the molecular pathways through which empagliflozin could exert hepatoprotector beneficial effects in T2DM.
Validation of the French Version of the Positivity Scale (P Scale)
Authors: Vancappel Alexis , Courtois Robert , Siragusa Marta , Hingray Coraline , Réveillère Christian , Caprara Gianvittorio , Belzung Catherine , El-Hage Wissam 
Published: February 2022

BackgroundThe purpose of this study is to assess the psychometric properties of the French version of the Positivity scale (P scale), a self-report measure of positivity, which is the tendency to view and address life and experience with a positive outlook. Positivity is seen as a latent factor underlying multiple cognitive concepts such as self-esteem, life satisfaction, and optimism.MethodsWe recruited 666 volunteers (540 women and 126 men). They completed the P scale online, as well as self-report measures of psychological well-being, self-esteem, satisfaction with life, general health, and personality dimensions. The study sample was randomly split into two sub-groups, one used for exploratory factor analysis and the other for confirmatory factor analysis.ResultsWe found conflictual results related to the uni-dimensionality of the French version of the P scale. We found good internal consistency and high concurrent validity.ConclusionThe French version of the P scale demonstrated good psychometric qualities and is a reliable tool that can now be used by French researchers and clinicians to assess positivity.
Psychometric Evaluation of the Parent Effort Scale
Authors: Bevans Katherine B. , Hallock Taye M. , Piller Aimee , Pfeiffer Beth 
Published: February 2022

ObjectiveThe Parent Effort Scale (PES) is a parent report questionnaire designed to quantify the level of effort required of caregivers to assist their children in developmentally appropriate home- and community-based activities. This manuscript describes the psychometric evaluation of the PES.MethodData collected from 304 parents of children ages 2–7 years (167 parents of a children with autism spectrum disorder and 137 parents of neurotypical children) were factor analyzed, calibrated using item response theory, and evaluated for construct validity.ResultsThe final PES scales are reliable and valid measures of the level of parental effort required to assist children in dressing, personal hygiene, sleep, socialization at home, participation in community events, and access to healthcare. A total score reflects overall parental effort.ConclusionThe PES can be used to plan and evaluate the effectiveness of interventions that aim to help parents enhance children's participation opportunities and thus, support their cognitive and social development.
Teratoid Wilms Tumor and Classical Wilms Tumor: A Retrospective 10-Year Single-Center Study and Literature Review
Authors: Wu Wei , Wu Yibo , Xu Weijue , Liu Jiangbin , Lv Zhibao 
Published: February 2022

BackgroundOne of the most prevalent forms of renal tumors detected among pediatric patients is the Wilms tumor (WT). Teratoid WT is a rare WT subclassification that is characterized by teratoma-like characteristics that include the features of many diverse tissue categories. Less than 70 teratoid Wilms tumor (TWT) cases have been explained up to now.MethodsBetween 2010 and 2020, patients with classical WT and TWT admitted to our hospital were included in this study. Clinicopathological characteristics, intraoperative findings, histopathological parameters, and prognostic outcomes were then compared between classical WT and TWT. To compare these variables, TWT and WT cases were matched at a 1:3 ratio.ResultsA total of 67 total WT cases, i.e., five diagnosed with TWT, were enrolled. While no significant differences in analyzed variables were detected between these groups, tumor volumes were notably larger in the TWT group relative to the classical WT group (203.30 ± 109.89 vs. 104.30 ± 66.97 cm3) despite similar tumor weight values in both groups (471.00 ± 80.65 vs. 432.67 ± 109.25 g). As for five patients diagnosed with TWT, all were alive during the follow-up, while one of them was diagnosed with pelvic metastasis.ConclusionsThis study is the first to our knowledge to have reported on the incidence of TWT among Chinese children, and our results preliminarily suggest that a combination of surgery and chemotherapy may be appropriate for the treatment of patients with WT, although prognostic outcomes varied substantially among patients with different stages of the disease. TWT tumor density may be lower than classical WT tumor density. Further research regarding the basic biological characteristics of TWT and relevant theranostic markers associated with this tumor type is warranted to better guide the development of individualized treatments for this rare cancer type.
Efecto de mastitis subclínica sobre la fertilidad en vacas Holstein, criadas en el trópico alto
Authors: Malta García Yesenia Ivonne , Zambrano Juan José , Matute Deleg Tania Ximena , Pinos Rojas Erika Estefanía , Dutan Sanango Jorge Bolívar , Ayala Guanga Luis Eduardo 
Published: February 2022

Effect of subclinical mastitis on fertility in Holstein cows, handling in the high tropics
Resumen
Se realizaron tres experimentos: 1) se evaluó el efecto de mastitis subclínica (MSC) sobre el porcentaje de preñez (PP), tras la primera IA pos diagnóstico de MSC, se utilizaron dos grupos: T1=sanas (n=60); T2=con MSC (n=60). 2) se valoró el tamaño del folículo preovulatorio (FPO) y el porcentaje de ovulación (POV), en 40 vacas con MSC (T2) y 40 sanas (T1), se aplicó un protocolo convencional de IATF para valorar el tamaño del FPO y PVO. 3) se determinó el nivel de estradiol (E2) en sangre y líquido folicular, en 10 vacas sanas (T1) y 10 con MSC (T2). Se observó un 68,3% de PP en T1 y T2 el 48,3% (P<0,05). El FPO de T1 (16,2±0,29 mm) fue similar a T2 (15,9±0,39 mm; P>0,05). El POV fue >T1 (61,9%) vs T2 (38,1%) (P<0,05). El E2 en plasma de T1 (55,4±2,28 pg/ml) y T2 (66,1±3,39 pg/ml) difirieron (P<0,05). En líquido folicular el E2 fue >T2 (1760,1±46,4 pg/ml) vs T1 (1486,9±69,8 pg/ml). La MSC reduce en un 20% el PP; sin embargo, esta no guarda relación con el tamaño del FPO, pero si reduce un 23,8% de ovulaciones, posiblemente relacionado con mayor concentración de estradiol tanto en suero como en líquido folicular.
Palabras claves: Folículo preovulatorio; Líquido folicular; suero; Estradiol; ovulación
Abstract
Three experiments were carried out: 1) the effect of subclinical mastitis (MSC) on the percentage of pregnancy (PP) was evaluated. After the first AI after MSC diagnosis, two groups were used: T1 = healthy (n = 60); T2 = with MSC (n = 60). 2) The pre-ovulatory follicle size (FPO) and the ovulation percentage (POV) were valued, in 40 cows with MSC (T2) and 40 healthy (T1) a conventional IATF protocol was applied to assess the size of the FPO and PVO. 3) The level of estradiol (E2) in blood and follicular fluid was determined in 10 healthy cows (T1) and 10 with MSC (T2). 68.3% PP was observed in T1 and T2 48.3% (P <0.05). The FPO of T1 (16.2 ± 0.29 mm) was similar to T2 (15.9 ± 0.39 mm; P> 0.05). The POV was> T1 (61.9%) vs T2 (38.1%; P<0.05). The E2 of T1 (55.4 ± 2.28) and T2 (66.1 ± 3.39 pg / ml) differed (P <0.05). In follicular fluid, E2 was> T2 (1760.1 ± 46.4 pg / ml) vs T1 (1486.9 ± 69.8 pg/ml). MSC reduces PP by 20%; however, this is not related to the size of the FPO, but it does reduce ovulations by 23.8%, possibly related to a higher concentration of estradiol in both serum and follicular fluid.
Keywords: Pre-ovulatory follicle; Follicular fluid; serum; Estradiol; ovulation.
Empoderamiento en estudiantes universitarios de enfermería desde la percepción del clima organizacional
Authors: Scarsi Maratuech Rossana Mirtha , Pérez Gutarra Guillermina Delia , Cristobal Tembladera Carolina Mercedes 
Published: February 2022

El empoderamiento en estudiantes universitarios de enfermería, es una oportunidad para posicionar la profesión. Objetivo. Determinar la relación que existe entre empoderamiento y clima organizacional en estudiantes universitarios de enfermería. Materiales y Métodos. Estudio correlacional, transversal, realizado en Huancayo, Perú, entre marzo y diciembre de 2018. La población estuvo conformada por 189 estudiantes de enfermería, y el tamaño de la muestra (n=166) se obtuvo con la fórmula para muestras finitas y el muestreo fue aleatorio simple. Se aplicó un cuestionario validado por cada variable. Para el análisis de datos, se empleó la estadística descriptiva e inferencial, se trabajó con el software IBM SPSS Statistics 24, se aplicó para la contratación de hipótesis el coeficiente de correlación de Pearson (r). Resultados. El 58,43% y el 39,15%, muestran un nivel de empoderamiento medio y alto y el 84,34% perciben que el clima organizacional en el espacio académico es medianamente favorable, lo que determina una relación directa entre el empoderamiento y clima organizacional en estudiantes de enfermería (0,335), significativa (p = 0,000 < 0,05). Conclusiones. Se demuestra que existe relación directa entre empoderamiento y clima organizacional, al evidenciar un alto porcentaje de estudiantes universitarios de enfermería que perciben nivel medio en ambas variables, lo cual puede ser considerado como una brecha para el desarrollo personal y profesional del estudiante y de la organización.
Profesionalisme Pengawas dalam Pengembangan Mutu Guru Madrasah
Authors: Masrullah Fitriah , Ghufron Ghufron 
Published: February 2022

Pengawas madrasah merupakan sumberdaya yang seyogyanya memiliki keunggulan dan kapasitas di atas rata-rata guru lainnya. Pengawas dituntut untuk senantiasa memberikan bantuan dan layanan kepada personel guru serta membina dan mengembangkan madrasah yang efektif, efisien, dan bermutu, serta bermartabat. Penelitian ini merupa-kan kajian pustaka dengan menggunakan studi dokumenter dalam pengumpulan data, sedangkan analisis datanya menggunakan analisis isi. Hasil penelitian ini menunjukkan bahwa problematika kepengawasan dan pengembanagan mutu madrasah terletak pada kurangnya komitemen bersama untuk bisa menjadi lebih baik. Oleh karena itu, peningkatan mutu pendidikan memerlukan komitmen yang tinggi dari semua komponen yang menjadi penggerak madrasah tersebut. Tiap langkah dalam mewujudkan mutu pendidikan yang baik di madrasah memerlukan kedisiplinan, tanggung jawab, dan komitmen kolektif.
Kata kunci: madrasah, mutu guru, profesionalisme pengawas
The madrasah supervisor is a resource that should have an advantage and a capacity above the average teacher. Supervisors are required to provide constant help and service to teacher personnel and to build and develop effective, efficient, and high-quality madrasah and dignity. The study was a library research using a documentary technique in data collection, while its data analysis used content analysis. The results of this study showed that management and stewardship lied in the lack of mutual commitment to improve. Therefore, improved education required high commitment from all the components that drive the madrasah. Each step in achieving a good education in the madrasah required discipline, responsibility, and a collective commitment.
Kebijakan Pengembangan Guru di Era Society 5.0
Authors: Hermawan Iwan , Supiana Supiana , Zakiah Qiqi Yuliati 
Published: February 2022

Era society 5.0 merupakan kelanjutan dari era revolusi industri 4.0 yang lebih menonjolkan sisi humanisme dalam menyelesaikan masalah-masalah sosial termasuk pendidikan dengan mengintegrasikan antara virtual dan realita. Penelitian ini bertujuan untuk menganalis kebijakan pemerintah tentang pengembangan guru di era society 5.0 dengan mengunakan sumber data atau referensi yang berupa buku, jurnal, prosiding dan lain-lain yang secara umum disebut library research. Terdapat beberapa kondisi dan penyebab dari rendahnya kualitas profesi guru, antara lain: 1) Belum tercapainya standarisasi kualifikasi akademik guru minimal D4/S1 sebagaimana tercantum dalam Permendiknas Nomor 16 Tahun 2007, 2) Pengembangan kompetensi guru yang seringkali terhambat karena faktor internal dan eksternal, 3) Rekrutmen guru yang tidak efektif,4) Kesejahteraan guru berupa penghasilan yang masih sangat kecil dan tidak sebanding dengan tugas guru sebagai pembentuk watak dan peradaban manusia.Walaupun kebijakan-kebijakan strategis dari pemerintah yang berkaitan dengan keempathal tersebut sudah ada, namun implementasinya masih sangat kurang apalagi jika dihubungkan dengan kebutuhan era society 5.0 yang menuntut profesionalisme guru yang handal dalam menyiapkan generasi unggul masa kini dan masa yang akan datang.
Kata kunci: kebijakan pemerintah, pengembangan guru, era society 5.0
The era of society 5.0 is a continuation of the era of the industrial revolution 4.0 which further emphasizes the side of humanism in solving social problems including education by integrating virtual and reality. This study aims to analyze government policies on teacher development in the era of society 5.0 by using data sources or references in the form of books, journals, proceedings, and others which are generally called library research. There are several conditions and causes for the low quality of the teaching profession, including: 1) The standardization of minimum academic qualifications of D4/S1 teachers has not been achieved as stated in Permendiknas No. 16 of 2007, 2) Teacher competence is often hampered due to internal and external factors, 3) Ineffective teacher recruitment, 4) Teacher welfare in the form of income which is still very small and not comparable to the teacher's duty as a form of human character and civilization. Even though strategic policies from the government relating to these five things already exist, their implementation is still lacking, especially when connected with the needs of the 5.0 era society which demands reliable professionalism in preparing superior generations today and in the future.
Temperature-dependent optical properties of ε-Ga2O3 thin films
Authors: Makino Takayuki , Yusa Subaru , Oka Daichi , Fukumura Tomoteru 
Published: February 2022

Abstract
We determined the complex dielectric functions of ε-Ga2O3 using optical transmittance and reflectance spectroscopies at temperatures from 10 K to room temperature. The measured dielectric-function spectra reveal distinct structures at bandgap energy. We fitted a model dielectric function based on the electronic energy-band structure to these experimental data. We analyzed the temperature dependence of the bandgap with a model based on phonon dispersion effects. One could explain it in terms of phonon-related parameters such as the optical phonon temperature. We compare phonon-related properties of ε-Ga2O3 with those of a large variety of element and binary semiconductors.
Calculation of Gibbs partition function with imaginary time evolution on near-term quantum computers
Authors: Matsumoto Keisuke , Shingu Yuta , Endo Suguru , Kawabata Shiro , Watabe Shohei , Nikuni Tetsuro , Hakoshima Hideaki , Matsuzaki Yuichiro 
Published: February 2022

Abstract
The Gibbs partition function is an important quantity in describing statistical properties of a system in thermodynamic equilibrium. There are several proposals to calculate the partition functions on near-term quantum computers. However, the existing schemes require many copies of the Gibbs states to perform an extrapolation for the calculation of the partition function, which could be costly performed on the near-term quantum computers. We propose a scheme to calculate the Gibbs function with the imaginary time evolution. After preparing Gibbs states with different temperatures by using the imaginary time evolution, we measure the overlap between them on a quantum circuit, which allows us to calculate the Gibbs partition function. Our scheme requires only 2N qubits to calculate the Gibbs function of N qubits.