bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modifiable Risk Factors Are Important Predictors of COVID-19-Related Mortality in Patients on Hemodialysis
Authors: Kooman Jeroen Peter , Carioni Paola , Kovarova Vratislava , Arkossy Otto , Winter Anke , Zhang Yan , Bellocchio Francesco , Kotanko Peter , Zhang Hanjie , Usvyat Len , Larkin John , Stuard Stefano , Neri Luca 
Published: July 2022

IntroductionPatients with end-stage kidney disease face a higher risk of severe outcomes from SARS-CoV-2 infection. Moreover, it is not well known to what extent potentially modifiable risk factors contribute to mortality risk. In this historical cohort study, we investigated the incidence and risk factors for 30-day mortality among hemodialysis patients with SARS-CoV-2 infection treated in the European Fresenius Medical Care NephroCare network using conventional and machine learning techniques.MethodsWe included adult hemodialysis patients with the first documented SARS-CoV-2 infection between February 1, 2020, and March 31, 2021, registered in the clinical database. The index date for the analysis was the first SARS-CoV-2 suspicion date. Patients were followed for up to 30 days until April 30, 2021. Demographics, comorbidities, and various modifiable risk factors, expressed as continuous parameters and as key performance indicators (KPIs), were considered to tap multiple dimensions including hemodynamic control, nutritional state, and mineral metabolism in the 6 months before the index date. We used logistic regression (LR) and XGBoost models to assess risk factors for 30-day mortality.ResultsWe included 9,211 patients (age 65.4 ± 13.7 years, dialysis vintage 4.2 ± 3.7 years) eligible for the study. The 30-day mortality rate was 20.8%. In LR models, several potentially modifiable factors were associated with higher mortality: body mass index (BMI) 30–40 kg/m2 (OR: 1.28, CI: 1.10–1.50), single-pool Kt/V (OR off-target vs on-target: 1.19, CI: 1.02–1.38), overhydration (OR: 1.15, CI: 1.01–1.32), and both low (&lt;2.5 mg/dl) and high (≥5.5 mg/dl) serum phosphate levels (OR: 1.52, CI: 1.07–2.16 and OR: 1.17, CI: 1.01–1.35). On-line hemodiafiltration was protective in the model using KPIs (OR: 0.86, CI: 0.76–0.97). SHapley Additive exPlanations analysis in XGBoost models shows a high influence on prediction for several modifiable factors as well, including inflammatory parameters, high BMI, and fluid overload. In both LR and XGBoost models, age, gender, and comorbidities were strongly associated with mortality.ConclusionBoth conventional and machine learning techniques showed that KPIs and modifiable risk factors in different dimensions ascertained 6 months before the COVID-19 suspicion date were associated with 30-day COVID-19-related mortality. Our results suggest that adequate dialysis and achieving KPI targets remain of major importance during the COVID-19 pandemic as well.
Development of a Novel Prognostic Model of Glioblastoma Based on m6A-Associated Immune Genes and Identification of a New Biomarker
Authors: Luo Na , Sun Xizi , Ma Shengling , Li Xiaoyu , Zhu Wenjun , Fu Min , Yang Feng , Chen Ziqi , Li Qianxia , Zhang Yuanyuan , Peng Xiaohong , Hu Guangyuan 
Published: July 2022

BackgroundAccumulating evidence shows that m6A regulates oncogene and tumor suppressor gene expression, thus playing a dual role in cancer. Likewise, there is a close relationship between the immune system and tumor development and progression. However, for glioblastoma, m6A-associated immunological markers remain to be identified.MethodsWe obtained gene expression, mutation, and clinical data on glioblastoma from The Cancer Genome Atlas and Chinese Glioma Genome Atlas databases. Next, we performed univariate COX–least absolute shrinkage and selection operator (LASSO)–multivariate COX regression analyses to establish a prognostic gene signature and develop a corresponding dynamic nomogram application. We then carried out a clustering analysis twice to categorize all samples according to their m6A-regulating and m6A-associated immune gene expression levels (high, medium, and low) and calculated their m6A score. Finally, we performed quantitative reverse transcription-polymerase chain reaction, cell counting kit-8, cell stemness detection, cell migration, and apoptosis detection in vitro assays to determine the biological role of CD81 in glioblastoma cells.ResultsOur glioblastoma risk score model had extremely high prediction efficacy, with the area under the receiver operating characteristic curve reaching 0.9. The web version of the dynamic nomogram application allows rapid and accurate calculation of patients’ survival odds. Survival curves and Sankey diagrams indicated that the high-m6A score group corresponded to the groups expressing medium and low m6A-regulating gene levels and high m6A-associated prognostic immune gene levels. Moreover, these groups displayed lower survival rates and higher immune infiltration. Based on the gene set enrichment analysis, the pathophysiological mechanism may be related to the activation of the immunosuppressive function and related signaling pathways. Moreover, the risk score model allowed us to perform immunotherapy benefit assessment. Finally, silencing CD81 in vitro significantly suppressed proliferation, stemness, and migration and facilitated apoptosis in glioblastoma cells.ConclusionWe developed an accurate and efficient prognostic model. Furthermore, the correlation analysis of different stratification methods with tumor microenvironment provided a basis for further pathophysiological mechanism exploration. Finally, CD81 may serve as a diagnostic and prognostic biomarker in glioblastoma.
Integrated Community Case Management Utilization Status and Associated Factors Among Caretakers of Sick Children Under the Age of 5 Years in West Shewa, Ethiopia
Authors: Debel Lemessa Negeri , Nigusso Fikadu Tadesse 
Published: July 2022

ObjectiveTo assess the utilization status and associated factors of integrated community case management (ICCM) of caretakers with &lt;5 years of sick children.MethodsCommunity-based cross-sectional study was employed with caretakers whose child was sick in the last 3 months before data collection. Bivariate and multivariable logistic regression analyses were employed.ResultsAbout 624 respondents participated in the study; 325 (52.1%) utilized integrated community case management. Caring for children between the ages 24–36 months old, (AOR = 1.26, 95%CI: 0.23, 0.90); women health development army (WHDA) training, (AOR = 5.76, 95%CI: 3.57, 9.30); certified as model family, (AOR = 3.98, 95%CI: 2.45, 6.46); perceived severity, (AOR = 5.29, 95%CI: 2.64, 10.60); awareness of danger sign, (AOR = 2.76, 95%CI: 1.69, 4.50), and awareness of ICCM, (AOR = 5.42, 95%CI: 1.67, 17.58) were associated with ICCM utilization.ConclusionThis study revealed that age of the child, caretakers' awareness of ICCM, awareness of danger signs, illness severity, women's health developmental army training, and graduation as a model family were associated with ICCM utilization. Therefore, it is recommended that promote health education using community-level intervention modalities focusing on common childhood illness symptoms, danger signs, severity, and care-seeking behavior.
A practical and economical method for frontal sinus reconstruction after frontal craniotomy: A single-center experience with 140 patients
Authors: Guo Youwei , Fu Xianyong , Yin Wen , Jiang Zhipeng , Kuang Yirui , Wu Zhaoping , Cao Yudong , Tan Jun , Jiang Xing-jun 
Published: July 2022

BackgroundFrontal sinus exposure is a common consequence of frontal craniotomy. Cerebrospinal fluid leakage and infection are the major postoperative complications that may occur as a result of the open frontal sinus. The successful filling of the open frontal sinus provides an approach to prevent significant complications caused by frontal sinus exposure.ObjectiveThis article describes a new technique to reconstruct the exposed frontal sinus cavity with the combined application of gelatin sponge and a vascularized pericranial flap.MethodsA total of 140 patients underwent frontal sinus reconstruction using gelfoam and vascularized pericranial flaps from 2016 to 2021. Gelatin sponge was used to fill the frontal sinus, and a vascularized pericranial flap was used to cover the frontal sinus when the bone flap was retracted.ResultsPostoperative cerebrospinal fluid leakage and infection did not occur in any patient.ConclusionOur results validated the effectiveness of our technique in the prevention of exposed frontal sinus-related postoperative complications.
Factors Associated With HIV Testing Among MSM in Guilin, China: Results From a Cross-Sectional Study
Authors: Zhou Jianfang , Yang Lu , Ma Jingyi , Jiang Shenyue , Liu Yuelong , Sun Zhiming 
Published: July 2022

Objectives: The objective of this study is to explore factors affecting the HIV testing behaviors among men who have sex with men (MSM) in China.Methods: A cross-sectional study was conducted in Guilin, China from April to June of 2021. Questionnaire data of 300 MSM were analyzed, and binary logistic regression models were used to examine the socio-demographic and sexual behavior characteristics associated with three HIV testing behaviors (self-testing, institutional testing, and regular testing).Results: The results showed that half of the respondents had the habit of regular HIV testing. Only 30.0% of MSM chose to do HIV testing after high-risk sexual behavior, and self-perceived luck was the main reason for not having HIV testing. Moreover, the influencing factors of three HIV testing behaviors after high-risk sexual behavior differ. Interestingly, income was not related to any of the three HIV testing behaviors among those MSM who participated.Conclusion: This research indicates insufficient health education on HIV testing behaviors among MSM in China. Health promotion practices targeting the MSM population to improve HIV-related knowledge, thus contributing to the HIV epidemic, are required.
Profiling Antibiotic Resistance in Acinetobacter calcoaceticus
Authors: Glover Janiece S. , Ticer Taylor D. , Engevik Melinda A. 
Published: July 2022

Background: Acinetobacter spp. have emerged as troublesome pathogens due to their multi-drug resistance. The majority of the work to date has focused on the antibiotic resistance profile of Acinetobacter baumannii. Although A. calcoaceticus strains are isolated in the hospital setting, limited information is available on these closely related species. Methods & Results: The computational analysis of antibiotic resistance genes in 1441 Acinetobacter genomes revealed that A. calcoaceticus harbored a similar repertoire of multi-drug efflux pump and beta-lactam resistance genes as A. baumannii, leading us to speculate that A. calcoaceticus would have a similar antibiotic resistance profile to A. baumannii. To profile the resistance patterns of A. calcoaceticus, strains were examined by Kirby–Bauer disk diffusion and phenotypic microarrays. We found that Acinetobacter strains were moderately to highly resistant to certain antibiotics within fluoroquinolones, aminoglycosides, tetracyclines, and other antibiotic classes. These data indicate that A. calcoaceticus has a similar antibiotic resistance profile as A. baumannii ATCC 19606. We also identified that all Acinetobacter species were sensitive to 5-fluoroorotic acid, novobiocin, and benzethonium chloride. Conclusion: Collectively, these data provide new insights into the antibiotic resistance in A. calcoaceticus and identify several antibiotics that could be beneficial in treating Acinetobacter infections.
A New Species of Limnephilus (Insecta: Trichoptera: Limnephilidae) from China, with Revision of the Genus Limnephilus on the Chinese Mainland
Authors: Zang Haoming , Ge Xinyu , Peng Lang , Sun Changhai , Wang Beixin 
Published: July 2022

Fifty individuals of Limnephilus from the Qinghai Province, China, were examined, and their COI barcode sequences were extracted and analyzed. Forty individuals of Limnephilus from the Insect Collection of Nanjing Agricultural University (ICNAU), China, were examined, and photos of the male genitalia of four Limnephilus species are here presented. The males, females, larvae, and pupae of a new species, Limnephilus deqianensis n. sp., associated via COI barcode sequences, are described and illustrated. Ecological photos of the male, pupal case, and the habitat of the new species L. deqianensis n. sp. are also provided. Five species groups containing all seventeen Chinese Limnephilus species are revised. Diagnoses, keys, and a distribution map of them are provided. All of the sequences have been uploaded to GenBank. All specimens are deposited in the ICNAU, Nanjing, Jiangsu Province, P. R. China.
A New Cretaceous Dustywing Genus (Neuroptera: Coniopterygidae) with Peculiar Wing Venation
Authors: Chen Zuluan , Wang Lihua , Zhuo De , Xu Chunpeng , Liu Xingyue 
Published: July 2022

The species and morphological diversity of dustywings (Neuroptera: Coniopterygidae) from the Cretaceous, of which the knowledge is rapidly increasing by recent studies on the species from the mid-Cretaceous Kachin amber, provide valuable evidence for understanding the phylogeny and early evolution of this highly specialized lacewing lineage. Here we describe a new genus and two new species of this genus in Coniopterygidae from the mid-Cretaceous (lowermost Cenomanian) of northern Myanmar, namely Paradoxoconis szirakii gen. et sp. nov. and Paradoxoconis longipalpa gen. et sp. nov. The new genus possesses a peculiar combination of wing characters, e.g., the terminal fusion or connection between ScP and RA, the terminal connection of RA to RP, the presence of forewing A3, and the presence of a distal gradate series of crossveins. Despite uncertain subfamilial placement, this new genus morphologically resembles the extant genus Coniocompsa Enderlein, 1905 of the subfamily Aleuropteryginae and the extant genus Flintoconis Sziráki, 2007 of the subfamily Brucheiserinae. Our finding highlights the palaeodiversity of dustywings from the Cretaceous.
Micro-Siting of Wind Turbines in an Optimal Wind Farm Area Using Teaching–Learning-Based Optimization Technique
Authors: Hussain Muhammad Nabeel , Shaukat Nadeem , Ahmad Ammar , Abid Muhammad , Hashmi Abrar , Rajabi Zohreh , Tariq Muhammad Atiq Ur Rehman 
Published: July 2022

Nowadays, wind energy is receiving considerable attention due to its availability, low cost, and environment-friendly operation. Wind turbines are rarely placed individually but rather in the form of a wind farm with a group of several wind turbines. The purpose of this research is to perform studies on wind turbine farms in order to find the best distribution for wind turbines that maximizes the produced power, hence minimizing the wind farm area. Wind Farm Area Optimization (WFAO) is performed for optimal placement of wind turbines using elitist teaching–learning-based optimization (ETLBO) techniques. Three different scenarios of wind (first is fixed wind direction and constant speed, second is variable wind direction and constant speed, and third is variable wind direction and variable speed) are considered to find the optimal number of turbines and turbine positioning in a minimized squared land area that maximizes the power production while minimizing the total cost. Other research carried out in the past was to find the optimal placement of the wind turbines in a fixed squared land area of 2 km×2 km. In the present study, WFAO–ETLBO algorithm has been implemented to get the optimal land area for the placement of the same number of turbines used in the past research. For Case 1, there is a significant reduction in land area by approximately 30.75%, 45.25%, and 51.75% for each wind scenario, respectively. For Case 2, the reductions in land area for three different wind scenarios are respectively 30.75%, 7.2%, and 7.2%. For Case 3, there is a reduction of 7.2% in land area for each wind scenario. It has been observed that the results obtained by the WFAO–ETLBO algorithm with a significant reduction in the land area along with optimal placement of wind turbines are better than the results obtained from the wind turbines placement in the fixed land area of 2 km×2 km.
Effects of dopant type and concentration on surface recombination velocity in hydrogen-terminated silicon
Authors: Araki Nobue , Udono Haruhiko 
Published: July 2022

Abstract
Isolating the effects of the type and concentration of the dopant in lightly doped regions in the reaction between hydrogen-terminated silicon surface and atmospheric impurities in air is very difficult. However, changes in the surface recombination sites can be analyzed accurately through recombination lifetime measurements performed using the microwave photoconductive decay method. Thus, we investigated variations in the effective recombination lifetime in hydrogen-terminated silicon surfaces over time in air for different dopant types and concentrations. For both p-type and n-type silicon wafers, surface recombination velocity, S, increased with decreasing resistivity, namely, increasing dopant concentration. The time-dependent variations of the S for the p-type wafers decreased, and those for the n-type wafers increased with decreasing resistivity. Thus, it was shown that the time-dependent variation of the S depends on the type and concentration of the dopant used.
Enhanced nitrogen incorporation in the 〈112̄0〉 directions on the (0001̄) facet of 4H-SiC crystals
Authors: Hashiguchi Takato , Ota Takuto , Asano Shunsuke , Ohtani Noboru 
Published: July 2022

Abstract
Enhanced nitrogen doping in the 〈11

2
¯

0〉 directions on the (000

1

¯

) facet of 4H-SiC crystals grown by the physical vapor transport (PVT) growth method was investigated using Raman scattering microscopy and atomic force microscopy (AFM). The enhanced nitrogen doping showed either single or double peak structure of nitrogen incorporation in the azimuthal direction around 〈11

2
¯

0〉. AFM observations revealed that these two characteristic doping structures stemmed from different propagation morphologies of spiral steps on the (000

1

¯

) facet. It was also unveiled that the change in the step-flow direction was always associated with the change of the terrace-width ratio on the facet, and that the interplay between these two parameters determined the nitrogen incorporation on the (000

1

¯

) facet. On the basis of these experimental results, the mechanism of the azimuthal dependence of nitrogen incorporation on the (000

1

¯

) facet during PVT growth of 4H-SiC crystals is discussed.
PERBEDAAN PROFIL HEMATOLOGI PADA PENDERITA TUBERKULOSIS PARU YANG MENJALANI PENGOBATAN
Authors: Karwiti Witi , Lestari Wuni Sri , . Nasrazuhdy , Rezekiyah Sholeha 
Published: July 2022

Tuberkulosis di Indonesia ini juga merupakan penyebab nomor empat kematian setelah penyakit Cardiovaskular. Berdasarkan data dari Dinas Kesehatan Provinsi Jambi tahun 2017, didapatkan bahwa Kota Jambi menempati urutan pertama dengan jumlah penemuan pasien Tuberkulosis paru baru BTA positif sebesar 1.172 kasus.Tuberkulosis dapat menimbulkan kelainan hematologi, baik sel-sel hematopoiesis maupun komponen plasma. Kelainan-kelainan tersebut sangat bervariasi dan kompleks.Kelainan – kelainan hematologis ini dapat merupakan bukti yang berharga sebagai petanda diagnosis, pentunjuk adanya komplikasi atau merupakan komplikasi obat-obat anti tuberkulosis (OAT). Penelitian ini bertujuan untuk mengetahui perbedaan profil hematologi (Hb, LED, HT, sel eritrosit, sel lekosit dan sel trombosit) pada pasien tuberculosis paru yang menjalani pengobatan. Metode penelitian berupa observasional dengan Sampel sebanyak 35 pasien yang memenuhi criteria inklusi kemudian diperiksa profil hematologi sebelum pengobatan dan setelah menjalani pengobatan fase 1. Proprosi tertinggi penderita tuberculosis berdasarkan sosiodemografi pada wanita 54,16%, usia 32-42 (37,1%), pendidikan menengah 51,4% dan pekerjaan swasta 51,4%. Parameter hematologi Hb ada perbedaan denga p=0,001, LED ada perbedaan p= 0,005, Hematokrit tidak ada perbedaan p=0,066, sel eritrosit ada perbedaan p=0,011, sel lekosit tidak ada perbedaanp=0,116, dan sel trombosit tidak ada perbedaan p=0,728.Terdapat perbedaan yang bermakna pada parameter hemoglobin,LED dan sel eritrosit. Pengobatan pasien tuberculosis
The SNR of positron emission data with Gaussian and non-Gaussian time-of-ﬂight kernels, with application to prompt photon coincidence
Authors: Nuyts Johan , Defrise Michel , Gundacker Stefan , Roncali Emilie , LECOQ Paul 
Published: July 2022

<p>This paper analyses noise propagation in positron emission tomography (PET). It presents a method to compute the effective signal-to-noise ratio provided by the time-of-flight (TOF) measurement.</p>
<p>The proposed method can be used to compare TOF-PET systems with different and possibly event-dependent TOF-kernels, as encountered when prompt photons, such as Cherenkov photons are present, or when the detector is composed of different scintillators. </p>
The complex issue of medication management in older persons: a challenge for nurses
Authors: Vitiello Carmen Maria , Longobucco Yari , Espinoza Tofalos Sofia , Di Bari Mauro 
Published: July 2022

With increasing life expectancy, the share of older persons with coexisting multiple chronic degenerative diseases (comorbidity / multimorbidity) is expanding. These conditions require the use of multiple drugs, leading to polypharmacy, which plays a central role in making the therapeutic approach to the elderly particularly complex, together with age-related changes in pharmacokinetics and pharmacodynamics.
Physicians and nurses both are challenged by polypharmacy and by the other drug-related issues involving older patients, in all care settings. In particular, nurses should be aware of the main issues of pharmacotherapy in older persons, because they are often the frontline for older patients care, especially in nursing homes.
This review addresses the main issues related to pharmacotherapy in late life, such as pharmacokinetics and pharmacodynamics changes, limitations of evidence-based medicine, polypharmacy, drug interactions, adverse drug reactions, and lack of adherence. Focus will be on how these problems may impact on nursing, and on what nurses should know and do to improve drug treatment of older patients.
In the last decade, the role and responsibilities of nurses in the management of drug therapy have significantly changed in most countries. There is consensus in educational programs and legislation that the preparation and administration of medications are essential aspects of nursing practice. These are considered as collaborative tasks with physicians and not purely mechanistic tasks. The nurse must intervene in the event of a perceived error, and he/she must report doubts about congruity or relevance of the therapy.
Although nursing students gain knowledge and develop skills on drug therapy during their education, these are often perceived as insufficient. The need for post-graduation continuing education should be also emphasized. Thus, graduate and post-graduate educational programs should be developed, in order to offer adequate answers to the increasing and challenging share of older patients seen in clinical practice.
PHOTON WORLD
Authors: Хурамшин Иштимер Шагалиевич , Хурамшин Рустем Иштимерович 
Published: July 2022

Утверждается, что вся барионная материя и темная энергия, состоят из фотонов и фотонных частиц (ФЧ). Последние образующие форму кольца, имеют свою топологию и приобретают массу и заряд. Этот процесс является переходом энергии в материю. Из ФЧ формируются элементарные частицы и атомы. Огромная часть лучистой энергии заполняет все пространство Вселенной, которое называется темной энергией и веществом.It is asserted that baryon matter and dark energy are composed of photons and photonic particles (PP). The last ones that form the ring shape have their own topology and acquire mass and charge. This process is the transition of energy into matter. Elementary particles and atoms are formed from PP. A huge part of the radiant energy fills the entire space of the Universe, which is called dark energy and matter.