bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stroke-related length of hospitalization trends and in-hospital mortality in Peru
Authors: Labán-Seminario L. Max , Carrillo-Larco Rodrigo M. , Bernabé-Ortiz Antonio 
Published: November 2022

Background
Peru faces challenges to provide adequate care to stroke patients. Length of hospitalization and in-hospital mortality are two well-known indicators of stroke care. We aimed to describe the length of stay (LOS) of stroke in Peru, and to assess in-hospital mortality risk due to stroke, and subtypes.

Methods
This retrospective cohort study used hospitalization registries coding with ICD-10 from 2002 to 2017 (N = 98,605) provided by the Ministry of Health; in-hospital mortality was available for 2016–2017 (N = 6,566). Stroke cases aged ≥35 years were divided into subarachnoid hemorrhage (I60), intracerebral hemorrhage (I61), cerebral infarction (I63), and stroke not specified as hemorrhage or infarction (I64). Data included stroke LOS and in-hospital mortality; socio-demographic and clinical variables. We fitted a region- and hospital level-stratified Weibull proportional hazard model to assess the in-hospital mortality.

Results
The median LOS was 7 days (IQR: 4–13). Hemorrhagic strokes had median LOS longer than ischemic strokes and stroke not specified as hemorrhage or infarction (P = <0.001). The case fatality rate (CFR) of patients with stroke was 11.5% (95% CI [10–12%]). Subarachnoid hemorrhage (HR = 2.45; 95% CI [1.91–3.14]), intracerebral hemorrhage (HR = 1.95; 95% CI [1.55–2.46]), and stroke not specified as hemorrhage or infarction (HR = 1.45; 95% CI [1.16–1.81]) were associated with higher in-hospital mortality risk in comparison to ischemic strokes.

Discussion
Between 2002 and 2017, LOS due to stroke has not changed in Peru in stroke patients discharged alive. Hemorrhagic cases had the longest LOS and highest in-hospital mortality risk during 2016 and 2017. The findings of our study seem to be consistent with a previous study carried out in Peru and similar to that of HIC and LMIC, also there is an increased median LOS in stroke cases managed in specialized centers. Likewise, LOS seems to depend on the type of stroke, where ischemic stroke cases have the lowest LOS. Peru needs to improve access to stroke care.
Estilos de liderança e comprometimento organizacional dos contadores que trabalham de forma remota
Authors: Lizote Suzete Antonieta , Silva Danuzi da , Mendes Maria das Graças Correa , Tridapalli Lucas Ademir 
Published: November 2022

Este estudo teve como objetivo avaliar a relação entre o estilo de liderança e o comprometimento organizacional dos contadores que trabalham de forma remota. Uma pesquisa de levantamento foi realizada com contadores que trabalham de forma remota em escritórios de contabilidade localizados nos municípios da Associação dos Municípios da Região da Foz do Rio Itajaí/SC. Dos 225 convites enviados para participar da pesquisa, 184 foram aceitos, aos quais foi enviado o link do questionário. Os construtos foram mensurados com os instrumentos de Bass e Avolio (2004) e Meyer e Allen (1991). Para testar as hipóteses, realizou-se a análise de correlação bivariada de Pearson. Os resutlados evidenciaram que a liderança transformacional mostrou correlação positiva com todas as dimensões, entretanto, significativa somente com índice de comprometimento e comprometimento afetivo-normativo. A liderança transacional, mostrou relação significativa com todas as variáveis de comprometimento, entretanto, apresentou relações inversas. Já a liderança laissez-faire apresentou relação positiva com comprometimento instrumental-normativo e relações negativa com comprometimento afetivo-normativo e com índice de comprometimento. Estes resultados, teoricamente ampliam o escopo das análises dos estilos de liderança e o comprometimento organizacional. Quanto a contribuição prática, ao proceder a análise conjunta destes constructos, este entendimento poderá contribuir para subsidiar o processo decisório de gestores em diferentes ambientes.
Gears and Modes of Exploitation of Edible Frogs in the Peri-Urban Localities of Man, Côte d'Ivoire
Authors: Casimir Ble Yatanan , Faustin Zouh Bi Zahouli , Norbert Kouadio Kouakou , Adjehi Dadie 
Published: November 2022

Aims: The study carried out aimed to evaluate the modes of exploitation of edible frogs.
Place and Duration of Study: The present study was performed during the month of January to February 2022. The survey was conducted in the villages of Kassiapleu, Kouitongouiné and Gbangbégouiné. These villages are located in MAN (West of Côte d’Ivoire).
Methodology: Surveys have been carried out among actors exploiting this animal resource. The study involved 210 consumers and 15 frog harvesters in the locality of MAN. A well-structured questionnaire provided data on fishing techniques and frog consumption patterns.
Results: This study reveals that there are two main fishing methods: arrow fishing (57.1%) and hook and line fishing (42.9%). The catches are made in different humid ecological zones and the exploitation is only intended for local consumption. The smoked form is the most popular with consumers (59.5%). The majority of respondents consume this meat because of the taste (83.3%) compared to that of chicken (44.8%) and fish (31.4%).
Conclusion: In view of these results obtained, the establishment of a rational exploitation strategy must be considered for the conservation of edible frog species.
Natural Honey Beneficial to Health, Its Chemical Composition, and Biochemical Activities: A Review
Authors: Karapetkovska-Hristova Vesna , Mustafa Syed Khalid 
Published: November 2022

Since early antiquity, honey has been utilized worldwide as a balanced meal and in supplementary treatment. It contains over 200 different substances, the majority of which are water, sugars, vitamins, enzymes, amino acids, minerals, and phytochemicals. It has health advantages, including microbial inhibition, healing, and its influence on other disorders. Additionally, it stimulates the immune system and helps immune cells mature. The nutritional value of honey is substantially influenced by the type of plants in the region, the climate, and the production process. Different types of honey were examined by various workers, they found a strong relationship between honey type and HMF, saccharose, and phenolic content, as well as acidity and antioxidant activity. For the level of vitamin C, glucose, and fructose, the combination of variety and manufacturing technique has a substantial influence. The focus of this study is on the biochemical processes and its potential health benefits. However, the precise mechanisms of honey's influence on many illnesses and activities have not yet been fully defined, and more study is necessary to understand their precise contributions.
Antioxidants and Biomarkers of Inflammation as Risk Factors of Vascular Cognitive Impairment in Adult Hypertensives
Authors: Aborisade Oluyinka Bamidele , Charles-Davies Mabel Ayebatonyo , Owolabi Mayowa Ojo , Agbedana Emmanuel Oluyemi 
Published: November 2022

Background: Impairment in cognition and attention involving memory loss characterize Vascular Cognitive Impairment (VCI), a complication of hypertension. The involvement of antioxidants and inflammatory biomarkers in the progression of hypertension to VCI is controversial and is investigated in this study.
Methods: A total of 216 normoglycaemic individuals (aged 40-75 years) were enrolled into this case control study by systematic sampling method. They consisted of 81 Newly Diagnosed Hypertensives (NDH) without cognitive impairment, 69 Newly Diagnosed Hypertensives with Cognitive Impairment (NDHCI) attending Medical Outpatient Clinic and 66 apparently healthy individuals without hypertension or cognitive impairment (Controls), who were members of staff of University College Hospital, Ibadan. Socio-demographic indices and lifestyle were obtained through a semi-structured questionnaire while Systolic and Diastolic tg6bn Blood Pressure (SBP and DBP, respectively) were obtained using standard methods. Neuropsychological assessment based on Cognitive Score (CS) was performed using Community Screening Instrument for Dementia. Antioxidants [Glutathione (GSH), Catalase (CAT) and Superoxide Dismutase (SOD)] and inflammatory biomarkers [Interleukin-6 (IL-6), High sensitivity C - reactive protein (hs-CRP)] in serum were estimated by ELISA. Data were analysed using Statistical Package for Social Sciences (SPSS) software 17.0 version. Analysis of variance (ANOVA) and Post Hoc test were used for comparison of variables while Chi square test was used to find associations between variables. Data analysed were significant at p<0.05.
Results: The inflammatory biomarkers hs-CRP (0.14±0.01; 0.12±0.01 versus 0.11±0.01 mg/L; p<0.001) and IL-6 (301.62±17.61; 115.60±16.01 versus 51.41±1.60 ng/mL; p<0.001) were significantly higher in NDHCI and NDH relative to control, respectively. Significant decreases in mean activities of catalase (81.71±1.01; 285.10±5.51 versus 403.00±17.31 ng/mL; p<0.001), SOD (5.04±0.97; 9.67±0.70 versus 12.02±0.53 ng/mL; p<0.007), GSH (7.02±0.89, 8.91±0.90; 20.5±1.31μg/mL; p<0.001) and cognitive scores (3.51±0.41; 18.81±0.50 against 28.71±0.20; p<0.001) were found in NDHCI compared with NDH and control, respectively.
Conclusion: Increased oxidative stress and inflammatory processes may underlie the progression of hypertension to cognitive impairment.
Hormone Positive HER2 Negative Breast Cancer Metastatic to the Rectum: A Case Report
Authors: Chehal Aref , Alakkad Ashraf , Uttamchandani Ashok , Mohamed Rawia , Church Robert Douglas , Otsmane Sonia 
Published: November 2022

Background: The rectum is an uncommon site for metastases from Invasive Ductal Carcinoma (IDC) of the breast, and it poses risks such as perforation and obstruction.
Case Report: A 50-year-old non-diabetic, non-alcoholic, and nonsmoker premenopausal female patient diagnosed with rectal metastasis primarily originating from breast cancer.
In 2009, the patient was diagnosed with stage IV hormone positive, Her-2 (+2) negative, FISH positive right breast cancer with cervical (C6) vertebrae metastasis seen on PET scan. As she had oligo metastasis with a single bony focus, she was treated with intent to cure. For this purpose, she received radiation therapy to the cervical vertebrae, resulting in a complete response. This was followed by pseudo-neoadjuvant chemotherapy with six cycles of Docetaxel and trastuzumab. The patient then underwent a right-modified radical mastectomy. The pathology showed no complete response with residual 2.5 cm invasive carcinoma (PT2), and 4 out of 25 Axillary lymph nodes were positive for metastases (PN2). She was given (pseudo) adjuvant radiotherapy to the chest wall and lymphatics and was started on (pseudo) adjuvant tamoxifen. Trastuzumab was completed for one year as a (pseudo) adjuvant setting.
Her disease seemed to be cleared up as no new cancer signs were reported by follow-up full body scans (CT/PET). After seven years, in May 2016, her PET-CT scan showed multiple new hypermetabolic osseous lesions, in keeping with metastasis involving the right shoulder, mid-thoracic spine, left aspect of L5, right sacrum, and the greater trochanteric region of the left femur and left ischium. She also presented a new hypermetabolic retroperitoneal paracaval lymph node, in keeping with metastasis. The new ill-defined hypodensity in the left hepatic lobe was associated with increased FDG uptake, which is suspicious for early metastasis. She also presented a tiny right lung peri-fissural nodularity that was too small to be characterized by PET.
She was treated with Zoladex 3.6 mg injection monthly, Femara 2.5 mg daily, Palbociclib 125 mg PO daily for 21 days over a 28-day cycle, and Denosumab 120 mg monthly. The treatment was initiated in Singapore. As previously stated, Her-2 testing was reported as negative. The patient went into complete remission for more than six years, as documented by the PET scan conducted on January 19, 2022. Later, in June 2022, the patient developed signs and symptoms of intestinal obstruction (abdominal pain, nausea, and vomiting) and was diagnosed with rectal cancer metastases of breast origin.
Conclusion: As the patient first developed breast cancer with oligo-bony metastasis, which was successfully treated with chemotherapy and radiotherapy, but later relapsed in the lung, liver, lymph nodes, and multiple bony sites. She was treated successfully via hormonal and targeted therapy. Finally, she relapsed in the form of rectal metastasis.
Corporate health culture promotes infection control measures against COVID-19 in the workplace
Authors: Nagata Tomohisa , Odagami Kiminori , Nagata Masako , Mori Koji 
Published: November 2022

Abstract

Objectives
The present study examined the relationship between health culture evaluated by the Health and Productivity Survey Sheets and the implementation status of infection control measures against COVID-19 in the workplace.

Methods
This was a cross-sectional study using the corporate data (2518 companies) collected for the purpose of selecting the excellent company of health and productivity management by the Japanese government. The explanatory variable was the overall evaluation score, and the outcome was whether or not infection control measures against COVID-19 in the workplace. We used logistic regression analysis and calculated the odds ratio adjusted for the industry sector, the corporation size, and the operating profit ratio by the overall evaluation score category.

Results
The odds ratio of all infection control measurements in the workplace increased as the evaluation score increased.

Conclusions
This study revealed a new finding that the presence of a healthy culture in the workplace will lead to the appropriate implementation of infection control measures during a pandemic. The company's ordinary commitment to employee health will be effective even in times of health crisis, such as during the outbreak of the pandemic.
Porous Proton Exchange Membrane with High Stability and Low Hydrogen Permeability Realized by Dense Double Skin Layers Constructed with Amino tris (methylene phosphonic acid)
Authors: Li Wen , Liu Wen , Zhang Jin , Wang Haining , Lu Shanfu , Xiang Yan 
Published: November 2022

AbstractPorous proton exchange membranes (PEMs) with abundant porous structures show enhanced phosphoric acid (PA) doping levels and proton transport capability. However, the high PA loss rate and serious hydrogen cross‐over lead to poor membrane stability. Enhancing the stability of PA‐doped porous PEMs is therefore crucial for obtaining high‐performance proton exchange membrane fuel cells. Herein, a porous polybenzimidazole membrane with dense double skin layers is reported using amino tris (methylene phosphonic acid) (ATMP) constructed. This membrane effectively alleviates hydrogen permeation and PA loss in a water/anhydrous environment and exhibits enhanced stability. Surprisingly, as an organic proton conductor, ATMP has strong hydrogen bonding with PA, leading to the formation of more continuous proton transport channels. Due to the dense double skin layers protection and the synergistic mass transfer of ATMP and PA, the porous membrane shows excellent proton conductivity (0.112 S cm−1) and a H2‐O2 fuel cell peak power density of 0.98 W cm−2 at 160 °C. Moreover, it presents excellent fuel cell stability, with a voltage decay rate of only 5.46 µV h−1. In addition, the porous membrane surpasses the traditional working temperature range, operating in the range of 80–220 °C. This study provides new insight into developing high‐performance porous PEMs.
Precisely Constructed Metal Sulfides with Localized Single‐Atom Rhodium for Photocatalytic C−H Activation and Direct Methanol Coupling to Ethylene Glycol
Authors: Wang Limei , Sun Yu , Zhang Fuyong , Hu Jingting , Hu Wentao , Xie Shunji , Wang Yongke , Feng Jun , Li Yubing , Wang Genyuan , Zhang Biao , Wang Haiyan , Zhang Qinghong , Wang Ye 
Published: November 2022

AbstractAlthough there are many studies on photocatalytic environmental remediation, hydrogen evolution, and chemical transformations, less success has been achieved for the synthesis of industrially important and largely demanded bulk chemicals using semiconductor photocatalysis, which holds great potential to drive unique chemical reactions that are difficult to implement by the conventional heterogeneous catalysis. The performance of semiconductors used for photochemical synthesis is, however, usually unsatisfactory due to limited efficiencies in light harvesting, charge‐carrier separation, and surface reactions. The precise construction of heterogeneous photocatalysts to facilitate these processes is an attractive but challenging goal. Here, single‐atom rhodium‐doped metal sulfide nanorods composed of alternately stacked wurtzite/zinc‐blende segments are successfully designed and fabricated, which demonstrate record‐breaking efficiencies for visible light‐driven preferential activation of C−H bond in methanol to form ethylene glycol (EG), a key bulk chemical used for the production of polyethylene terephthalate (PET) polymer. The wurtzite/zinc‐blende heterojunctions lined regularly in one dimension accelerate the charge‐carrier separation and migration. Single‐atom rhodium selectively deposited onto the wurtzite segment with photogenerated holes accumulated facilitates methanol adsorption and C−H activation. The present work paves the way to harnessing photocatalysis for bulk chemical synthesis with structure‐defined semiconductors.
A MgFe‐LDH Nanosheet‐Incorporated Smart Thermo‐Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration
Authors: Lv Zehui , Hu Tingting , Bian Yixin , Wang Guanyun , Wu Zhikang , Li Hai , Liu Xueyan , Yang Shuqing , Tan Chaoliang , Liang Ruizheng , Weng Xisheng 
Published: November 2022

AbstractAlthough growth factor (GF)‐loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart hydrogels with excellent gelation/mechanical properties as well as controllable GF releasing capability. Herein, the incorporation of bone morphogenetic protein 2 (BMP‐2)‐functionalized MgFe‐layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) hydrogels loaded with platelet‐derived growth factor‐BB (PDGF‐BB) to construct a smart injectable thermo‐responsive hydrogel (denoted as CSP‐LB), which can achieve a burst release of PDGF‐BB and a sustained release of BMP‐2, for highly efficient bone regeneration is reported. The incorporation of MgFe‐LDH in CS hydrogel not only shortens the gelation time and decreases sol–gel transition temperature, but also enhances the mechanical property of the hydrogel. Because of the sequential release of dual‐GFs and sustained release of bioactive Mg2+/Fe3+ions, the in vitro experiments prove that the CSP‐LB hydrogel exhibits excellent angiogenic and osteogenic properties compared with the CS hydrogel. In vivo experiments further prove that the CSP‐LB hydrogel can significantly enhance bone regeneration with higher bone volume and mineral density than that of the CS hydrogel. This smart thermo‐sensitive CSP‐LB hydrogel possesses excellent gelation capability and angiogenic and osteogenic properties, thus providing a promising minimally invasive solution for bone defect treatment.
Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti‐Tumor Immunity in Murine Glioblastoma
Authors: Lugani Sophie , Halabi Elias A. , Oh Juhyun , Kohler Rainer H. , Peterson Hannah M. , Breakefield Xandra O. , Chiocca E. Antonio A. , Miller Miles A. , Garris Christopher S. , Weissleder Ralph 
Published: November 2022

AbstractMyeloid cells are abundant, create a highly immunosuppressive environment in glioblastoma (GBM), and thus contribute to poor immunotherapy responses. Based on the hypothesis that small molecules can be used to stimulate myeloid cells to elicit anti‐tumor effector functions, a synthetic nanoparticle approach is developed to deliver dual NF‐kB pathway‐inducing agents into these cells via systemic administration. Synthetic, cyclodextrin‐adjuvant nanoconstructs (CANDI) with high affinity for tumor‐associated myeloid cells are dually loaded with a TLR7 and 8 (Toll‐like receptor, 7 and 8) agonist (R848) and a cIAP (cellular inhibitor of apoptosis protein) inhibitor (LCL‐161) to dually activate these myeloid cells. Here CANDI is shown to: i) readily enter the GBM tumor microenvironment (TME) and accumulate at high concentrations, ii) is taken up by tumor‐associated myeloid cells, iii) potently synergize payloads compared to monotherapy, iv) activate myeloid cells, v) fosters a “hot” TME with high levels of T effector cells, and vi) controls the growth of murine GBM as mono‐ and combination therapies with anti‐PD1. Multi‐pathway targeted myeloid stimulation via the CANDI platform can efficiently drive anti‐tumor immunity in GBM.
A Paper‐Based Triboelectric Touch Interface: Toward Fully Green and Recyclable Internet of Things
Authors: Edberg Jesper , Boda Ulrika , Mulla Mohammad Yusuf , Brooke Robert , Pantzare Sandra , Strandberg Jan , Fall Andreas , Economou Konstantin , Beni Valerio , Armgarth Astrid 
Published: November 2022

AbstractThe transition to a sustainable society is driving the development of green electronic solutions designed to have a minimal environmental impact. One promising route to achieve this goal is to construct electronics from biobased materials like cellulose, which is carbon neutral, non‐toxic, and recyclable. This is especially true for internet‐of‐things devices, which are rapidly growing in number and are becoming embedded in every aspect of our lives. Here, paper‐based sensor circuits are demonstrated, which use triboelectric pressure sensors to help elderly people communicate with the digital world using an interface in the form of an electronic “book”, which is more intuitive to them. The sensors are manufactured by screen printing onto flexible paper substrates, using in‐house developed cellulose‐based inks with non‐hazardous solvents. The triboelectric sensor signal, generated by the contact between a finger and chemically modified cellulose, can reach several volts, which can be registered by a portable microcontroller card and transmitted by Bluetooth to any device with an internet connection. Apart from the microcontroller (which can be easily removed), the whole system can be recycled at the end of life.
Densely Packed Li‐Metal Growth on Anodeless Electrodes by Li+‐Flux Control in Space‐Confined Narrow Gap of Stratified Carbon Pack for High‐Performance Li‐Metal Batteries
Authors: Won Jong Ho , Sim Woo Hyeong , Kim Donghyoung , Jeong Hyung Mo 
Published: November 2022

AbstractLithium (Li) is the “holy grail” for satisfying the increasing energy demand. This is because of its high theoretical capacity and low potential. Although Li is considered as a potential anode material, dendritic Li growth and the limited electrochemical properties continue to hinder its practical application. Structure‐based self lithium ion (Li+) concentrating electrodes with high capacity and uniform Li+‐flux are recommended to overcome these shortcomings of Li. However, recent studies have been limited to structural perspectives. In addition, the electrokinetic principle of electrode materials remains a challenge. Herein, the space‐confinement‐based strategy is suggested for condensed Li+‐flux control in nanoscaled slit spaces that induce the dense Li growth on an anodeless electrode by using the stratified carbon pack (SCP). The micro/mesoporous slits of the SCP concentrate the electric field, which is strengthened by the space‐confined electric field focusing, resulting in the accumulation of Li+‐flux in the host. The accumulated Li+ in host sites enables a uniform Li deposition with high capacity at high current density stably. Furthermore, SCPs have great compatibility with LiNi0.8Co0.1Mn0.1O2 (NCM811) cathode, representing the outstanding full cell performance with Li deposited electrode which show the high specific of 115 mAh g−1 at 4 C during 350 cycles.