bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resource allocation for cellular device‐to‐device‐aided vehicle‐to‐everything networks with partial channel state information
Authors: Shan Liqing , Wang Michael Mao , Zhang Fenghui , Chen Shuaishuai , Zhang Jingjing 
Published: April 2022

AbstractIn Vehicle‐to‐Everything (V2X), cellular Device‐to‐Device (D2D) communication can not only enhance system capacity and spectral utilization but also reduce the traffic load and communication delay. However, due to the fast variations of the channel state information (CSI) caused by high mobility of vehicles, the accurate CSI is difficult to be obtained in real‐time. In this paper, different from other previous researches that are subject to the perfect CSI, a more realistic channel state model is adopted that only the partial CSI of the communication links is available. Then we study the joint power allocation and spectrum sharing problem to maximize the total weighted ergodic capacity of all vehicular links, namely, Vehicle‐to‐Infrastructure (V2I) links and Vehicle‐to‐Vehicle (V2V) links. Meanwhile, the transmission reliability guarantees the quality of service (QoS) requirements of V2I and V2V. Since the formulated problem is a nonconvex mixed integer nonlinear programming (MINLP) problem, we first derive the strategy for obtaining the optimal solution of power allocation under arbitrary weighted factor and quantify different cases of feasible regions. Then we propose a two‐stage algorithm to complete the optimal resource allocation in polynomial time. Moreover, we further propose a low‐complexity spectrum sharing method based on the principles of Gale‐Shapley mechanism. The simulation results show that the proposed algorithms outperform the other baseline schemes significantly, and the low‐complexity scheme can effectively achieve a tradeoff between performance and complexity.
A fine‐grained and secure health data sharing scheme based on blockchain
Authors: Chen Jiahao , Yin Xinchun , Ning Jianting 
Published: April 2022

AbstractElectronic health record (EHR) allows patients to use an open channel (ie, Internet) to control, share and manage their health records among family members, healthcare providers and other third party data users. Thus, in such an environment, privacy, confidentiality, and data consistency are the major challenges. Although cloud‐based EHR addresses the aforementioned discussions, these are prone to various malicious attacks, trust management and non‐repudiation among servers. Recently, due to the property of immutability, blockchain technology has been introduced to be as an auspicious solution for achieving EHR sharing with privacy and security preservation. Motivated by the above debates, we present BFHS, a blockchain‐based fine‐grained secure EHR sharing mechanism. On BFHS, we encrypt the EHR using ciphertext‐policy attribute‐based encryption (CP‐ABE) and upload it to the interplanetary file system (IPFS) for storage, while the matching index is encrypted via proxy re‐encryption and kept in a medical consortium blockchain. In addition, we created a credit assessment mechanism and incorporated it into the smart contract. Smart contracts, proxy re‐encryption, a credit evaluation mechanism, and IPFS all work together to give patients with a trustworthy EHR sharing environment and a dynamic access control interface. The thorough comparison and experimental analysis show that the proposed BFHS has more comprehensive security features and is more practicable.
Minimizing the monetary penalty and energy cost of server migration service
Authors: Fukushima Yukinobu , Suda Tatsuya , Murase Tutomu , Tarutani Yuya , Yokohira Tokumi 
Published: April 2022

AbstractCurrent IaaS (infrastructure as a service) cloud service may not satisfy communication QoS (quality of service) requirements of delay‐sensitive network applications, if there is a significant physical distance between a server of the network application (NetApp server) at a data center and its network application clients (NetApp clients). In order to improve communication QoS of NetApp clients, we propose server migration service (SMS) in this article. SMS allows NetApp servers to migrate among different locations in the network (1) to optimally locate themselves in relation to NetApp clients and mitigate the QoS degradation caused by location‐related factors (ie, propagation delays on network links) and (2) to optimally distribute traffic load over routers and processing load over (physical) computers and decrease the energy consumption. We develop a mixed‐integer programming model that determines when and to which locations NetApp servers migrate to minimize the total operating cost of SMS, that is, the sum of the monetary penalty incurred due to QoS violation and energy cost incurred due to energy consumption, while preventing NetApp servers from excessively migrating and adversely impacting QoS of the non‐SMS service that share the resource of the substrate network with SMS. Simulation results show that the model developed in this article achieves up to 42% lower total operating cost of SMS compared to the model that only minimizes the monetary penalty of SMS without considering the energy cost of SMS.
Preparation of freeze‐dried bioluminescent bacteria and their application in the detection of acute toxicity of bisphenol A and heavy metals
Authors: Yang Jun , Hu Shulin , Liao Anqi , Weng Yetian , Liang Shuli , Lin Ying 
Published: April 2022

AbstractCurrent chemical analysis approaches for contaminants have failed to reveal their biotoxicity. Moreover, conventional bioassays are time consuming and exhibit poor repeatability. In this study, we performed the acute toxicity detection of various contaminants (chromium (Cr), cadmium (Cd), lead (Pb), arsenic (As), mercury (Hg), tin (Sn), nickel (Ni), and bisphenol A (BPA)) with four bioluminescent bacteria (Vibrio qinghaiensis Q67, V. fischeri, Photobacterium phosphoreum T3, and P. phosphoreum 502) using a rapid, flexible, and low‐cost bioassay. We found that the temperature affected the bacterial luminescence, and freeze‐dried cells exhibited sensitive toxic responses to contaminants. Indeed, the optimized protectants containing 12% (w/v) trehalose, 4% sucrose, and 2% sorbitol displayed better luminescence and toxic sensitivity. Furthermore, freeze‐dried powders of these strains were prepared and subjected to acute toxicity detection. The results showed that all contaminants exhibited acute toxicity toward Q67, but the other strains did not show obvious response to nickel and tin. The relative half‐maximal effective concentration (EC50) values of BPA, Cr, Cd, Pb, As, Hg, Ni, and Sn to Q67 were 0.674, 1.313, 11.137, 5.921, 4.674, 0.911, 5.941, and 54.077 mg/L, respectively. In addition, the EC50 values of contaminants toward different strains were suggested to be statistically significant. Freeze‐dried Q67 exhibited toxic responses to more contaminants than the other bioluminescent strains; therefore, Q67 was selected to be more suitable than the other strains for single and mixture toxicity detection tests. Compared with other strains, Q67 was more appropriate for the rapid screening of the mixture toxicity of contaminants in samples as a nonspecific screening sensor before the use of standard analysis approaches.
New built and refurbished railway tunnels: Data delivery from BIM Models to OEBB's asset management
Authors: Großauer Karl , Huis Melanija , Jedlitschka Gernot , Matt Robert , Mulitzer Günther , Zwittnig Gerald 
Published: April 2022

AbstractDigitalisation in the construction industry has been progressing continuously and bringing major changes for everyone involved in virtually all areas. Austrian Federal Railways ÖBB has been pushing BIM (Building Information Modelling) for the construction and rehabilitation of their infrastructure. By means of various pilot projects, the basics and the processes required for design and construction are developed and applied with a strong focus on system operation. For Granitztal tunnel and a total length of ≈6.1 km, the as‐built design of the civil structures is done with an element‐based, open BIM model. As part of the handover to the maintenance and operation division, the data of civil structures relevant for operation are derived from the BIM model, validated by means of automatic methods and transferred to the facility management system (AVS, Anlagen‐Verzeichnis‐System). In the absence of an IFC (Industry Foundation Class) structure tunnel, a semantic and spatial data structure is developed. Furthermore, the model will be enriched with components of railway equipment. On the other hand, there is the over‐100‐year‐old Karawanks tunnel as part of the railway section between Villach and Jesenice. The line has been in operation since 1906 and includes the ≈8 km‐long, single‐tube Karawanks tunnel. The current situation of the tunnel including the superstructure and technical equipment no longer meets performance, safety and durability requirements and is being rehabilitated within an international cooperation project between Austria and Slovenia. The focus in this BIM project is set on the as‐built design and merging data of the existing historic tunnel structure with information of new components implemented during refurbishment. A core task is the structured transfer of data contained in the BIM model to the facility/asset management system of ÖBB (AVS) and the Slovenian infrastructure operator. The case histories of Granitztal tunnel and Karawanks tunnel are used to describe the implementation of BIM, including the development of required data structures, validation mechanisms and data delivery to the asset management.
Demands on digital data capturing of TBM and conventional tunnel drives
Authors: Sabanovic Nedzad , Wannenmacher Helmut , Stauch Felix , Fentzloff Wolfgang 
Published: April 2022

AbstractTunnels are significant in shaping our future infrastructure. Increasing limitations of the available ground require underground solutions for future infrastructure projects. Due to various reasons, boundary conditions for project realization are becoming more and more substantial, and the parties involved have to tackle a wide range of stakeholders' interests. Digitization may be able to handle some of these challenges and is one of the most relevant topics in the near future of the construction industry. First approaches of digital data capturing in different activity fields of project execution, such as geological and geotechnical conditions, survey, and reporting, are launched within Implenia's initiative. This article discusses essential aspects of data capturing, particularly in the light of the vast data volumes generated throughout tunnel construction in Europe and gives an insight into the various activities of Implenia on how to tackle these problems. The various TBM and drill‐and‐blast excavated tunnel projects illustrate the variability of data management and implemented solutions to work with the tremendous amount of data. In each case, one can clearly state that construction teams involved in digital data management highly appreciated the merits for their daily business: saving time, gaining transparent information, controlling processes, and more. The beneficial capability of appropriate data management in project execution is evident and will be carried out within Implenia's projects.
Risk of cardiovascular disease and loss in life expectancy in NAFLD
Authors: Shang Ying , Nasr Patrik , Widman Linnea , Hagström Hannes 
Published: April 2022

Abstract

Background and Aims
Conflicting evidence exists on cardiovascular disease (CVD) risk in patients with NAFLD, and data are lacking on whether NAFLD increases mortality after a CVD event. Moreover, life expectancy in NAFLD has not been studied. We therefore examined CVD risk and life expectancy in patients with NAFLD compared with the general population.

Approach and Results
In this nationwide population‐based cohort, all patients with NAFLD diagnosis and without baseline CVD (ascertaining from the Swedish National Patient Register from 1987 to 2016, n = 10,023) were matched 10:1 on age, sex, and municipality to individuals from the general population (controls, n = 96,313). CVD diagnosis and mortality were derived from national registers. Multistate models and flexible parametric survival models were used to estimate adjusted hazard ratios (aHRs) for CVD risk and loss in life expectancy due to NAFLD. We identified 1037 (10.3%) CVD events in patients with NAFLD and 4041 (4.2%) in controls. CVD risk was 2.6‐fold higher in NAFLD compared with controls (aHR = 2.61, 95% CI = 2.36–2.88) and was strongest for nonfatal CVD (aHR = 3.71, 95% CI = 3.29–4.17). After a nonfatal CVD event, the risk for all‐cause mortality was similar between patients with NAFLD and controls (aHR = 0.89, 95% CI = 0.64–1.25). Life expectancy in patients with NAFLD was, on average, 2.8 years lower than controls, with the highest loss of life‐years when NAFLD was diagnosed in middle age (40–60 years).

Conclusions
NAFLD was associated with a higher risk of nonfatal CVD but did not affect post‐CVD mortality risk. Patients diagnosed with NAFLD have a lower life expectancy than the general population.
The superiority of Epstein‐Barr virus DNA in plasma over in peripheral blood mononuclear cells for monitoring EBV‐positive NK‐cell lymphoproliferative diseases
Authors: Zheng Miao , Bao Yuhan , Wang Jiachen , Ma Yaxian , Yang Yang , Zhang Peiling , Chen Liting , Zheng Kai , Zhou Jianfeng 
Published: April 2022

AbstractEpstein‐Barr virus (EBV), characterized as an omnipresent virus, has been found able to infect NK cells and leads to NK‐cell type EBV‐positive lymphoproliferative diseases (EBV‐NK‐LPDs). We retrospective analyzed 202 EBV‐NK‐LPDs (including 64 CAEBV‐NK, 27 aggressive natural killer‐cell leukemia (ANKL), and 111 extranodal NK/T‐cell lymphoma (ENKTL)) patients' relationships between EBV DNA copies laboratory test results and clinical features. In CAEBV‐NK cohort, EBV DNA loads in either plasma or PBMCs had significant differences between the active state and the inactive state. Receiver operating characteristic curves were used to measure the diagnosis accuracy of EBV DNA copies. After comparing the area under the curve, EBV DNA loads in plasma had significantly higher accuracy in distinguishing disease activation than in PBMCs. Therefore, we propose redefining CAEBV‐NK diagnosis criteria as increased EBV DNA copies in plasma (over 7.1 × 102 copies/ml) instead of in peripheral blood. In ANKL and ENKTL cohorts, patients who received effective therapy had significantly lower EBV DNA copies in plasma & PBMCs than in those with ineffective therapy. The significant and consistent decline indicated EBV DNA loads in plasma being a more sensitive biomarker in monitoring EBV‐NK‐LPDs therapy responses. Hemophagocytic lymphohistiocytosis (HLH) can occur secondary to EBV‐NK‐LPDs, mostly associated with a poor prognosis, so we try to estimate the combination of HLH by monitoring EBV DNA copies. When comparing the Receiver operating characteristic curves of EBV DNA copies, EBV DNA loads in plasma had higher diagnosis accuracy. When the copies level over 4.16 × 103 copies/ml, it might indicate combining with HLH.
Risk factors, contemporary challenges and psychological well‐being of the Rohingya refugees in Bangladesh: Policy implications
Authors: Hossain Muhammad Anwar , Huda Md. Nazmul , Ullah A. K. M Ahsan , Renzaho Andre 
Published: April 2022

AbstractOver the last few years, the number of Rohingya refugees in Bangladesh has increased exponentially. On arrival, they experience poor mental health and psychological well‐being. This commentary explores the risk factors and contemporary challenges that deteriorate Rohingyas' psychological well‐being in Bangladesh. The onslaught of Covid‐19 compounds the pre‐existing psychological health conditions of the Rohingyas living in cramped and flimsy camps. The recent relocation to Bhashan Char may likely trigger tensions and eventually exacerbates their existing psychological well‐being. The relocation to Bhashan Char has presumably happened against their volition. Meanwhile, the Myanmar military's coup has added additional fear about their bleak future of a safe and dignified return from Bangladesh to Myanmar. All these have contributed to the worsening of their existing psychological well‐being. In order to subside their psychological health challenges, this commentary suggests: (a) the immediate execution of ‘National Deployment and Vaccination Plan for Covid‐19 Vaccines and initiation of vaccine rollout among the refugees; and (b) involving Rohingyas in economic activities and making them a self‐reliant and economically empowered community. We suggest that safe and dignified repatriation is the only solution to the challenges they have been going through in Bangladesh and to preserve their psychological well‐being.
The effect of trastuzumab on cardiac function in patients with HER2‐positive metastatic breast cancer and reduced baseline left ventricular ejection fraction
Authors: Bouwer Nathalie I. , Steenbruggen Tessa G. , Rier Hánah N. , Kitzen Jos J. E. M. , Smorenburg Carolien H. , van Bekkum Marlies L. , de Jong Paul C. , Drooger Jan C. , Holterhues Cynthia , Kofflard Marcel J. M. , Boersma Eric , Sonke Gabe S. , Levin Mark‐David , Jager Agnes 
Published: April 2022

AbstractWe investigated the effect of trastuzumab on cardiac function in a real‐world historic cohort of patients with HER2‐positive metastatic breast cancer (MBC) with reduced baseline left ventricular ejection fraction (LVEF). Thirty‐seven patients with HER2‐positive MBC and baseline LVEF of 40% to 49% were included. Median LVEF was 46% (interquartile range [IQR] 44%‐48%) and median follow‐up was 18 months (IQR 9‐34 months). During this period, the LVEF did not worsen in 24/37 (65%) patients, while 13/37 (35%) patients developed severe cardiotoxicity defined as LVEF <40% with median time to severe cardiotoxicity of 7 months (IQR 4‐10 months) after beginning trastuzumab. Severe cardiotoxicity was reversible (defined as LVEF increase to a value <5%‐points below baseline value) in 7/13 (54%) patients, partly reversible (defined as absolute LVEF increase ≥10%‐points from nadir to a value >5%‐points below baseline) in 3/13 (23%) patients and irreversible (defined as absolute LVEF increase <10%‐points from nadir and to a value >5%‐points below baseline) in 3/13 (23%) patients. Likelihood of reversibility was numerically higher in patients who received cardio‐protective medications (CPM), including ACE‐inhibitors, beta‐blockers and angiotensine‐2 inhibitors, compared to those who did not receive any CPM (71% vs 13%, P = .091). Sixty‐five percent of patients who received trastuzumab for HER2‐positive MBC did not develop severe cardiotoxicity during a median follow‐up of 18 months, despite having a compromised baseline LVEF. If severe cardiotoxicity occurred, it was at least partly reversible in more than two‐thirds of the cases. Risks and benefits of trastuzumab use should be balanced carefully in this vulnerable population.
Castration‐resistant prostate cancer diagnosed during leuprorelin treatment for spinal and bulbar muscular atrophy
Authors: Yanase Atsuhi , Sugihara Toru , Akimoto Takahiro , Yokoyama Hirotaka , Kamei Jun , Fujisaki Akira , Ando Satoshi , Naoi Tameto , Morita Mitsuya , Fujimura Tetsuya 
Published: April 2022

IntroductionWe report a prostate cancer case diagnosed during leuprorelin treatment for spinal and bulbar muscular atrophy which is a X‐linked recessive, lower motor neuron disease.Case presentationA 64‐year‐old man who had received leuprorelin treatment over 3 years for his spinal and bulbar muscular atrophy presented with an enlarged prostate accompanied by abdominal pain and constipation. An abnormally high serum prostate‐specific antigen of 17.7 ng/mL and a low (castration level) serum testosterone level of 0.23 ng/mL were measured. Prostate needle biopsy revealed adenocarcinoma of the prostate. Orchiectomy, darolutamide, and radiation therapy for the prostate were initiated, resulting in a favorable response which was maintained at 12 months of treatment.ConclusionProstate cancer can occur even when leuprorelin is used for spinal and bulbar muscular atrophy; therefore, checking serum prostate‐specific antigen to screen for prostate cancer before leuprorelin administration should be considered.
Loneliness and personal well‐being in young people: Moderating effects of individual, interpersonal, and community factors
Authors: Goodfellow Claire , Hardoon Deborah , Inchley Joanna , Leyland Alastair H. , Qualter Pamela , Simpson Sharon A. , Long Emily 
Published: April 2022

AbstractIntroductionLoneliness is prevalent among young people. But, there is little work exploring the association between loneliness with well‐being among this age group. Framed by social‐ecological theory, we examined demographic, interpersonal, and community factors associated with personal wellbeing and, critically, identified malleable moderators of the relationship between loneliness and well‐being that could be targeted in intervention efforts.MethodsWe used cross‐sectional, secondary data from 965 young people (aged 16–24) from the Community Life Survey in England. Loneliness was measured using a single‐item direct measure; personal wellbeing was measured through a composite measure containing items assessing happiness, life satisfaction, and a sense that life is worthwhile (α = 0.88). Regression techniques were used to assess associations between individual, interpersonal, and community factors and well‐being, and to identify moderators of the relationship between loneliness and well‐being.ResultsLoneliness was negatively associated with well‐being. Chatting with neighbors and having people to provide help moderated the relationship between loneliness and well‐being. Full‐time students and those with good physical health had higher well‐being while being a carer was predictive of lower well‐being. All community variables were strongly associated with increased well‐being. Of all interpersonal variables investigated, only having people to count on was associated with increased well‐being.ConclusionsOur results demonstrate that supportive relationships and close community ties are important for reducing the negative impact of loneliness on youth well‐being. Interventions to improve well‐being could benefit from targeting these aspects of young people's social and community lives, while acknowledging individual vulnerabilities, such as poor physical health.