bluuebunny/crossref_metadata_2025_split huggingface dataset:
A virtual laboratory based on full-field crystal plasticity simulation to characterize the multiscale mechanical properties of AHSS
Authors: Ma Hongyue , Li Yangqi , Zhang Haiming , Li Qian , Chen Fei , Cui Zhenshan 
Published: March 2022

AbstractIn this work, we proposed a virtual laboratory based on full-field crystal plasticity (CP) simulation to track plastic anisotropy and to calibrate yield functions for multiphase metals. The virtual laboratory, minimally, only requires easily accessible EBSD data for constructing the highly-resolved microstructural representative volume element and macroscopic flow stress data for identifying the micromechanical parameters of constituent phases. An inverse simulation method based on a global optimization scheme was developed to identify the CP parameters, and a nonlinear least-squares method was employed to calibrate yield functions. Mechanical tests of advanced high strength steel sheet under various loading conditions were conducted to validate the virtual laboratory. Three well-known yield functions, the quadratic Hill48 and non-quadratic Yld91 and Yld2004-18p yield functions, were selected as the validation benchmarks. All the studied functions, calibrated by numerous stress points of arbitrary loading conditions, successfully captured both the deformation and strength anisotropies. The full-field CP modeling correlated well the microscopic deformation mechanism and plastic heterogeneity with the macromechanical behavior of the sheet. The proposed virtual laboratory, which is readily extended with physically based CP models, could be a versatile tool to explore and predict the mechanical property and plastic anisotropy of advanced multiphase materials.
Lung tissue biomechanics imaged with synchrotron phase contrast microtomography in live rats
Authors: Cercos-Pita Jose-Luis , Fardin Luca , Leclerc Hugo , Maury Bertrand , Perchiazzi Gaetano , Bravin Alberto , Bayat Sam 
Published: March 2022

AbstractThe magnitude and distribution of strain imposed on the peripheral airspaces by mechanical ventilation at the microscopic level and the consequent deformations are unknown despite their importance for understanding the mechanisms occurring at the onset of ventilator-induced lung injury. Here a 4-Dimensional (3D + time) image acquisition and processing technique is developed to assess pulmonary acinar biomechanics at microscopic resolution. Synchrotron radiation phase contrast CT with an isotropic voxel size of 6 µm3is applied in live anesthetized rats under controlled mechanical ventilation. Video animations of regional acinar and vascular strain are acquired in vivo. Maps of strain distribution due to positive-pressure breaths and cardiovascular activity in lung acini and blood vessels are derived based on CT images. Regional strain within the lung peripheral airspaces takes average values of 0.09 ± 0.02. Fitting the expressionS = kVn, to the changes in peripheral airspace area (S) and volume (V) during a positive pressure breath yields an exponent n = 0.82 ± 0.03, suggesting predominant alveolar expansion rather than ductal expansion or alveolar recruitment. We conclude that this methodology can be used to assess acinar conformational changes during positive pressure breaths in intact peripheral lung airspaces.
Neurodevelopmental outcomes in very low birthweight infants with retinopathy of prematurity in a nationwide cohort study
Authors: Ahn Ja-Hye , Lee Kyeong Mi , Kim Mi Jung , Park Hyun-Kyung , Kim Yu Jeong , Ahn Seong Joon , Lee Hyun Ju 
Published: March 2022

AbstractIn a nationwide prospective cohort of Korean infants with very low birthweights (VLBW, birth weight < 1500 g) from 70 neonatal intensive care units of the Korean Neonatal Network, we investigated neurodevelopmental outcomes in preterm infants with retinopathy of prematurity (ROP) from 2132 infants with VLBW who had undergone developmental assessments at 18–24 months of corrected age. Motor, cognitive, or language delay was determined using developmental scores that were less than 1 standard deviation from the average. Comparative analyses and multivariate regression analyses were performed to validate the association between ROP or its treatment and developmental delay. Motor (52.8% vs. 36.3%), cognitive (46.8% vs. 31.6%), and language delays (42.5% vs. 28.4%) were noted more frequently in infants with ROP than in those without ROP; this was statistically significant (all P < 0.001). Multivariate analyses showed that motor and cognitive delays were significantly associated with ROP. There were no remarkable differences between the neurodevelopmental outcomes and the treatment modalities (laser photocoagulation, anti-vascular endothelial growth factor injection, or both) for ROP, and both stratification and multivariate regression analyses confirmed no significant association between anti-vascular endothelial growth factor therapy and neurodevelopmental delay. As ROP is significantly associated with poor neurodevelopmental outcomes independent of extreme prematurity, neurodevelopmental functions should be given attention in infants with ROP.
Emerging precision diagnostics in advanced cutaneous squamous cell carcinoma
Authors: Geidel Glenn , Heidrich Isabel , Kött Julian , Schneider Stefan W. , Pantel Klaus , Gebhardt Christoffer 
Published: March 2022

AbstractAdvanced cutaneous squamous cell carcinoma (cSCC) encompasses unresectable and metastatic disease. Although immune checkpoint inhibition has been approved for this entity recently, a considerable proportion of cases is associated with significant morbidity and mortality. Clinical, histopathological, and radiological criteria are used for current diagnostics, classification, and therapeutic decision-making. The identification of complex molecular biomarkers to accurately stratify patients is a not yet accomplished requirement to further shift current diagnostics and care to a personalized precision medicine. This article highlights new insights into the mutational profile of cSCC, summarizes current diagnostic and therapeutic standards, and discusses emerging diagnostic approaches with emphasis on liquid biopsy and tumor tissue-based analyses.
In-vitro engineered human cerebral tissues mimic pathological circuit disturbances in 3D
Authors: Saberi Aref , Aldenkamp Albert P. , Kurniawan Nicholas A. , Bouten Carlijn V. C. 
Published: March 2022

AbstractIn-vitro modeling of brain network disorders such as epilepsy remains a major challenge. A critical step is to develop an experimental approach that enables recapitulation of in-vivo-like three-dimensional functional complexity while allowing local modulation of the neuronal networks. Here, by promoting matrix-supported active cell reaggregation, we engineered multiregional cerebral tissues with intact 3D neuronal networks and functional interconnectivity characteristic of brain networks. Furthermore, using a multi-chambered tissue-culture chip, we show that our separated but interconnected cerebral tissues can mimic neuropathological signatures such as the propagation of epileptiform discharges.
Adjoint tomography of the Italian lithosphere
Authors: Magnoni Federica , Casarotti Emanuele , Komatitsch Dimitri , Di Stefano Raffaele , Ciaccio Maria Grazia , Tape Carl , Melini Daniele , Michelini Alberto , Piersanti Antonio , Tromp Jeroen 
Published: March 2022

AbstractThe evolution and state of geological structure at Earth’s surface is best understood with an accurate characterization of the subsurface. Here we present seismic tomographic images of the Italian lithosphere based on ground motion recordings and characterized by compressional and shear wavespeed structure at remarkable resolution, corresponding to a minimum period of ~10 s. Enhanced accuracy is enabled by state-of-the-art three-dimensional wavefield simulations in combination with an adjoint-state method. We focus on three primary findings of our model Im25. It highlights the distribution of fluids and gas (CO2) within the Italian subsurface and their correlation with seismicity. It illuminates Mt. Etna volcano and supports the hypothesis of a deep reservoir (~30 km) feeding a shallower magma-filled intrusive body. Offshore of the eastern Italian coast, it reveals that the Adriatic plate is made of two distinct microplates, separated by the Gargano deformation zone, indicating a complex lithosphere and tectonic evolution.
Frequency-magnitude distribution of earthquakes at Etna volcano unravels critical stress changes along magma pathways
Authors: Firetto Carlino Marco , Scarfì Luciano , Cannavò Flavio , Barberi Graziella , Patanè Domenico , Coltelli Mauro 
Published: March 2022

AbstractThe high seismic productivity of volcanic areas provides the chance to investigate the local stress conditions with great resolution, by analysing the slope of the frequency-magnitude distribution of earthquakes, namely theb-value. Here we investigated the seismicity of Mt. Etna between 2005 and 2019, focusing on one of the largest known episodes of unrest in December 2018, when most of the intruding magma aborted, rather oddly, its ascent inside the volcano. We found a possible stress concentration zone along magma pathways, which may have inhibited the occurrence of a larger eruption. If the origin of such hypothetical loaded region is related to tectonic forces, one must consider the possibility that geodynamic processes can locally result in such rapid crustal strain as to perturb the release of magma. Strongb-value time-variations occurred a few days before the unrest event, suggesting new possibilities for investigating the volcano state and impending eruptions.
A Combined Spoken Language Intervention for a Minimally Verbal Child With Autism: A Clinical Case Study
Authors: Biller Maysoon F. , Johnson Cynthia J. , Blue Kennedy B. 
Published: March 2022

Purpose:The purpose of this study was to explore the effect of a combined intervention program, incorporating both communication and speech production strategies, on the spoken language of a minimally verbal child with autism spectrum disorder (ASD).Method:This in-depth, clinical case study focused on a 4-year-old boy who was diagnosed with ASD. The study examined the spoken production of preselected words by the participant, using a combined intervention approach, consisting of three communication strategies and three speech production strategies during structured play. The target words were chosen based on aspects of neurotypical word learning during the first 50-word phase of language development. The combined intervention approach consisted of three communication strategies and three speech production strategies delivered during structured play activities.Results:The participant demonstrated improved spontaneous and imitative production of the target words during treatment and maintained production of the target words 1 month after treatment ended. Additionally, the boy demonstrated production of seven out of the eight target words on the posttreatment MacArthur–Bates Communicative Development Inventories (CDI): Words and Gestures, as well as an increase in the number of spoken words on the CDI that were more than what would be expected for a neurotypical child in a comparable developmental period. The communication strategy used most often was modeling (which required the child to respond), and the speech production strategy used most often was verbal modeling (which did not require the child to respond).Conclusions:There appeared to be a quantitative and qualitative difference in production of the target words before and after treatment. Clinical implications for using communication and speech production strategies in combination for minimally verbal children with ASD are discussed.
LeiP#netz – Leipziger Psychiatrie Netzwerk
Authors: Schwedhelm Justus , Frank Magdalena , Conrad Ines , Seyde Thomas , Steinhart Ingmar , Riedel-Heller Steffi , Koschig Maria , Stengler Katarina 
Published: March 2022

Zusammenfassung
Hintergrund Das Funktionale Basismodell (Steinhart, Wienberg) ist die theoretische Basis des hier vorgestellten pilotartigen Modellprojekts für eine konsequent ambulant gedachte Konzeption psychiatrischer Versorgung.
Methodik Teilziele (a) Netzwerkbildung mit in der Studienregion verorteten Anbietern/Einrichtungen/Akteur*innen und (b) Evaluation der vorgehaltenen Angebote und Maßnahmen i. S. eines Versorgungsmappings wurden verfolgt. Ein projektspezifisches Erhebungsinstrument für die Befragung aller Versorgungsakteur*innen wurde entwickelt und eingesetzt.
Ergebnis Der Prozess der intensivierten Vernetzung der in der Studienregion adressierten Akteur*innen konnte mit LeiP#netz erfolgreich begonnen werden. Alle für die Versorgung schwer psychisch erkrankter Menschen notwendigen Angebote sind in der Studienregion vorhanden. Während Beratung und Prävention eher gut vorgehaltene Strukturen und Angebote darstellen, mangelt es an niedrigschwelligen Zugängen wie Krisenmanagement, krankenhausalternativen Rückzugsorten und multiprofessioneller komplexer Behandlung im häuslichen Milieu.
Das Phytotherapeutikum Cimicifuga racemosa
(Traubensilberkerze)
Authors: Klose Petra 
Published: March 2022

ZusammenfassungFrauen mit Brustkrebs leben oft mit erheblichen Nebenwirkungen
einschließlich der Einleitung einer frühen Menopause, die
u. a. zu vasomotorischen Symptomen, Stimmungsschwankungen und
muskuloskelettalen Schmerzen führt. Präparate aus der
Traubensilberkerze (Cimicifuga racemosa) können hier eine
Therapieoption darstellen, da in zahlreichen Studien das geringe
Nebenwirkungspotenzial nachgewiesen werden konnte. Traubensilberkerze wirkt auch
nicht als Phytoöstrogen, was bei den meisten Brustkrebsarten
kontraindiziert wäre. Es gibt zudem Hinweise, dass die Einnahme von
Traubensilberkerze die Wirkung von Tamoxifen unterstützt. Studien zur
Linderung von Hitzewallungen bei menopausalen Frauen durch Traubensilberkerze
sind zwar nicht einheitlich, die Europäische Arzneimittelagentur EMA
kommt jedoch zu dem Schluss, dass die Nutzen-Risiko-Abwägung für
die Einnahme von Traubensilberkerze spricht. Zur Behandlung von
Brustkrebspatientinnen gibt es wenige Studien, und nur eine Studie, die
über einen längeren Zeitraum dauerte, zeigte signifikante
Linderung im Vergleich zur Kontrolle. Doch auch für
Brustkrebspatientinnen spricht die Datenlage zur Sicherheit nicht gegen die
Einnahme, sodass die EMA die Begleitung durch den behandelnden Arzt
empfiehlt.
Ten-Year Outcome of Topography-Guided Transepithelial Surface Ablation for Refractive Myopia Treatment
Authors: Branger Giacomo Alessandro , Le Minh Tu , Inauen Lars Oliver , Reichmuth Valentina , Kaufmann Claude , Baenninger Philipp 
Published: March 2022

Abstract
Background To evaluate 10-year long-term refractive visual stability and participantsʼ satisfaction in the refractive treatment of myopic eyes undergoing topography-guided
transepithelial surface ablation using a 1KHz excimer laser.
Patients and Methods This single-center prospective survey assessed participantsʼ satisfaction 10 years after the treatment using a non-validated questionnaire with regards to visual
outcome, dry eye, and visual disturbance symptoms. Pre- and postoperative visual and refractive data were evaluated.
Results Of 106 participants (54% females) with a mean patient age of 36 (± 8.6) years, 166 eyes were included. Mean preoperative spherical equivalent (SE) was − 4.23 (± 2.48)
diopters (D). Uncorrected distant visual acuity (UCVA) after 10 years was ≥ 1.0 (Snellen) in 92% of the eyes. Manifest SE was within ± 1.0 D of the desired refraction in 86% of the eyes
after 10 years. Mean quality of life (QOL) improvement was high (9.15 out of 10 points). Dry eye symptoms were reported by 35 out of 104 (34%) patients. Visual symptoms like halos or
starbursts were reported by 24 out of 101 (24%) and 12 out of 100 (12%) patients, respectively.
Conclusions Topography-guided transepithelial surface ablation for myopia provided stable long-term results in terms of UCVA and SE. Participant satisfaction was high, with only low
rates of dry eye or visual symptoms.
Efficacy of Diclofenac in Pain Reduction after Topography-Guided Transepithelial Surface Ablation
Authors: Jost Moritz , Pfaeffli Oliver , Kaufmann Claude , Reichmuth Valentina , Thiel Michael , Baenninger Philipp 
Published: March 2022

Abstract
Purpose To report the efficacy of postoperative diclofenac eye drops for pain reduction in patients undergoing topography-guided transepithelial surface ablation.
Methods Retrospective consecutive case series of patients undergoing topography-guided transepithelial surface ablation for refractive myopia treatment using a 1 KHz excimer laser.
Patients were divided into three groups. Group 1 did not receive any diclofenac drops, group 2 received one diclofenac drop postoperatively (day 1), and group 3 received one drop of
diclofenac postoperatively (day 1) and on the day after treatment (day 2). Postoperative pain was self-assessed by patients per eye daily for the first 4 consecutive days (days 1 to 4) after
the treatment using the visual analogue scale (VAS). We compared VAS with respect to the use of additional oral or topical treatment as well as VAS with regards to the total amount of
ablated tissue (< 50 µm, 50 – 100 µm, ≥ 100 µm) among the groups.
Results We enrolled 163 eyes of 163 patients (55.0% female), with a mean age of 31.3 years (SD ± 6.6; range 21 – 68). We excluded 16 patients who applied other additional analgesics.
Group 1 comprised 35 eyes (21%), group 2 had 21 eyes (13%), and group 3 consisted of 107 eyes (66%). Median pain score (VAS) was 5 (range 0, 10) in group 1, which was higher than in groups 2
(median 1, range 0 to 7) and 3 (median 1.5, range 0 to 7) on the day of surgery (p < 0.0001). Percentage of patients using an additional oral NSAID on days 1 and 2 was significantly
higher in group 1 (69/83%) when compared to groups 2 (24/43%) or 3 (31/49%) (p < 0.001 day 1, p = 0.001 day 2). No correlation was found between pain sensation and maximum ablation depth
(Spearman correlation p > 0.05).
Conclusion The instillation of one drop of diclofenac after topography-guided transepithelial surface ablation reduced subjective pain sensation according to VAS and decreased the
need for additional topical anesthetic drops or oral NSAID.
Öffentlich-rechtliche Unterbringung und Fahreignung –
Eine orientierende Untersuchung von verkehrsmedizinischer Relevanz für
den Öffentlichen Gesundheitsdienst und andere Akteure
Authors: Koch Johannes , Weigl Lorenz , Stich Heribert 
Published: March 2022

Zusammenfassung
Ziel der Studie Zielsetzung dieser Analyse war die Erfassung
sozialepidemiologischer Merkmale einer spezifischen Probandenpopulation nebst
der Identifizierung von Abhängigkeiten zwischen vormaligen
öffentlich-rechtlichen Unterbringungen und nachfolgenden Beurteilungen
der individuellen Fahreignung durch den ÖGD.
Methodik Für die retrospektive Datenanalyse wurden Dokumente von
87 Personen ausgewertet, die in den Jahren 2015 bis 2019 in psychiatrischen
Facheinrichtungen öffentlich-rechtlich untergebracht wurden. Unter
Verwendung des Software Pakets SAS wurden Häufigkeitsverteilungen und
mittels Chi-Quadrat-Test statistische Abhängigkeiten zwischen
spezifischen Merkmalen der Unterbringung und der Beurteilung der Fahreignung
identifiziert.
Ergebnisse Innerhalb der Studienkohorte lag das Durchschnittsalter bei
43,5 Jahren (Spannbreite von 16 bis 82 Jahren), wobei 59%
männlichen Geschlechtes (versus 41% weiblich) waren.
Häufigster Unterbringungsanlass waren Suizidankündigungen durch
die Betroffenen. In einem Drittel der Fälle waren diese Personen zum
Zeitpunkt der Unterbringung alkoholisiert und in 3 von 87 Fällen war ein
Drogenkonsum dokumentiert. Bei 74% erfolgte die Unterbringung
ausschließlich aufgrund einer Eigengefährdung, bei 26%
wurde (zusätzlich) eine Fremdgefährdung festgestellt und bei
20% der Betroffenen kam es zu einem verbalen und/oder
körperlichen Widerstand gegen die Vollstreckung der Unterbringung. Die
verkehrsmedizinische Begutachtung erbrachte bei 57% der Fälle
Zweifel an der Fahreignung, sodass dieser Sachverhalt an die
Fahrerlaubnisbehörde weitergeleitet wurde. Statistisch signifikante
Abhängigkeiten zeigten sich zwischen dem Unterbringungsanlass, der
Gefährdungsart und einem Widerstand gegen die
Unterbringungsvollstreckung zum Ergebnis der Fahreignungsbeurteilung durch den
ÖGD.
Schlussfolgerung Die Datengrundlagen über
öffentlich-rechtlich untergebrachte Personen in Verbindung mit
verkehrsmedizinischen Fragestellungen sollten qualitativ optimiert werden, wozu
das auf der Grundlage des Bayerischen Psychisch-Kranken-Hilfe-Gesetz
(BayPsychKHG) eingeführte anonyme Melderegister einen Beitrag leisten
kann. Ergänzend sind weitergehende Qualifizierungsmaßnahmen
aller involvierten Akteure im Sinne eines effektiven
Qualitätsmanagements notwendig.
Two-Year Outcome of Surgery in Glaucoma Patients
Authors: Hüppi Roger , Wagels Barbara , Todorova Margarita 
Published: March 2022

Abstract
Purpose To evaluate the 2-year surgical treatment outcome in glaucoma patients.
Methods A retrospective, single-center, interventional study was performed on 160 eyes of 125 patients suffering glaucoma, including POAG (82 eyes), pseudoexfoliation (PEX)
(59 eyes), pigment dispersion (8 eyes), and secondary glaucoma (2 eyes). Eyes with uncontrolled intraocular pressure (IOP) or signs of glaucoma progression despite medical treatment were
included to undergo either trabeculectomy (TE), XEN implantation, combined TE with phacoemulsification (TE + IOL), or XEN implantation with phacoemulsification surgery (XEN + IOL). Primary
efficacy outcome was the mean IOP reduction. Secondary outcome was the mean reduction in the number of medications. The data were compared at baseline vs.1 day, 1 week, and 1, 3, 6, 12, and
24 months following surgery. For statistical evaluation, ANOVA-based linear mixed-effects models were performed with SPSS.
Results The mean IOP reduction in a 2-year follow-up was 30.31% (22.17 vs. 15.45 mmHg, p < 0.001). The mean number of antiglaucoma medications was reduced from 2.87 to 0.58
(p = 0.001), where TE alone or combined surgeries seemed to be more effective than isolated XEN surgery. Transient IOP hypotony on the first postoperative day occurred in PEX patients
following TE surgery (p = 0.024). At 6 months, PEX patients with isolated XEN surgery showed a transient IOP increase, whereas those after combined TE + IOL surgery showed the lowest IOP
within the PEX group compared to other glaucoma patients (p < 0.026).
Conclusions After 2 years, all performed glaucoma surgeries achieved a significant reduction in IOP and the number of antiglaucoma medications.
Diagnostik der Alzheimer-Demenz bei Menschen mit einem Down-Syndrom
nach ICD, DSM-V und A/T/N-Klassifikation
Authors: Nübling Georg , Wagemann Olivia , Loosli Sandra V. , Wlasich Elisabeth , Danek Adrian , Levin Johannes 
Published: March 2022

ZusammenfassungViele Menschen mit einem Down-Syndrom (DS) haben aufgrund der Lokalisation des
Amyloid Precursor Protein (APP)-Gens auf Chromosom 21 eine Triplikation des
APP-Gens und daher ein sehr hohes Risiko, an einer DS-assoziierten
Alzheimer-Demenz (DS-AD) zu erkranken. Die Diagnosestellung der DS-AD stellt
eine besondere Herausforderung dar, zum einen aufgrund vielfältiger
Manifestationsformen von Gedächtnisstörungen bis hin zu
Verhaltensauffälligkeiten wie Rückzug und Aggression, zum
anderen aufgrund zahlreicher Differentialdiagnosen. Zur systematischen Erfassung
stehen aktuell die Diagnosesysteme ICD-10, DSM-V sowie das bei Menschen mit
einer intellektuellen Beeinträchtigung noch wenig etablierte
A(Amyloid)/T(Tau)/N(Neurodegeneration) System zur
Verfügung. In diesem Diskussionsbeitrag sollen verschiedene Aspekte der
Diagnostik unter spezieller Berücksichtigung der etablierten
Klassifikationssysteme einschließlich eines Ausblicks auf ICD-11
diskutiert und ein Algorithmus zur standardisierten Diagnosefindung
vorgeschlagen werden.