bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract IA-09: Liver cancer and differences across Hispanic groups: Importance of disaggregation in understanding cancer disparities
Authors: Pinheiro Paulo S. 
Published: January 2022

Abstract
The incidence of hepatocellular carcinoma (HCC) has risen considerably in the US since 1980. The main causes include metabolic disorders (NAFLD, diabetes, obesity, metabolic syndrome), alcohol-related disease (ALD) and hepatitis C and B virus infections (HCV, HBV). Etiology-specific HCC incidence rates by detailed race-ethnicity are needed to improve HCC control and prevention efforts. All HCC cases diagnosed in Florida during 2005-2018 were linked to statewide hospital discharge data to determine etiology. Age-specific and age-adjusted rates were used to assess the intersection between etiology and detailed racial-ethnicities, including non-Hispanic White, non-Hispanic Black and Hispanic groups: Mexican, Cuban, Puerto Rican, Dominican, South, Central American. Of 19,956 HCC cases including 3,660 Hispanics, 87% matched with discharge data. For 2012-2018, HCV was the leading cause of HCC White, Black and Hispanic men (45.4%, 54.7% and 41.0% respectively) followed by NAFLD-related metabolic disorders and ALD. The leading cause of HCC among White and Black women was also HCV (38.3% and 50.2%) while for Hispanic women NAFLD-HCC (46.7%) was the most common form. Puerto Rican men had the highest HCV-HCC rates, 10.2 per 100 000. Metabolic-HCC rates were highest among populations above age 70 and among all Hispanics except Cubans. Mexican men had high rates of ALD-HCC. HCC etiology is associated with specific race/ethnicity. While HCV-related HCC rates are projected to decrease soon, HCC will continue to affect Hispanics disproportionately, based on higher rates of metabolic-HCC and ALD-HCC. Multifaceted approaches for HCC control and prevention are needed.
Citation Format: Paulo S. Pinheiro. Liver cancer and differences across Hispanic groups: Importance of disaggregation in understanding cancer disparities [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA-09.
Abstract IA-11: Practical considerations in setting up a biobank
Authors: Hibshoosh Hanina 
Published: January 2022

Abstract
Biobanks are incredible natural treasures that in the age of personalized medicine and cost effective scaled multi-omic interrogation have become front and center in enabling the clinical and research enterprise. Despite this recognition, significant challenges exist in their operations. Traditional tissue banking Life cycle is summarized: Patient identification, consent, acquisition (generic/project specific), storage, processing, annotation, cohort identification for research and disbursal of tissues and related products and tracking/linkage to other resources containing data and material. Select topics in a banks practical operations will be briefly discussed including: 1. Not “normalizing” the description of these incredible treasures of nature, 2. Viewing them through the prism of their short and long term value, 3. Importance of scale and diversity, 4. Combined clinical and research utility, 5. Need to expand beyond operating room based collection to anywhere, anytime any analyte, 6. Distinguishing between and enabling population level collection and project and patient specific collection processes and its application to underrepresented populations, 7. Defining/identifying key skills required for its operating personnel, 8. Financial model beyond institutional and fee for service- need to nestle in an income generating facility and providing banking complimentary services, 9. Need for next generation platform to close gaps by reducing barriers to research, 10. Increase utilization and enable a collaboration platform, and 11. Procurement versus traditional banking function: supporting fresh tissue collection not for banking but PDX, organoids, single cell work, 12. Dedicated versus “Federated” system of operations. The above will enable successful implementation of biobanking operations and or their optimization.
Citation Format: Hanina Hibshoosh. Practical considerations in setting up a biobank [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA-11.
Abstract IA-13: Using large, prospective cohort data to elucidate sexual orientation-related cancer disparities
Authors: Charlton Brittany 
Published: January 2022

Abstract
Nearly half of U.S. men and women will develop cancer in their lifetime, but certain groups, such as sexual minorities (e.g., lesbian, gay, bisexual [LGB] individuals), may be at greater risk. For almost 20 years, the Institute of Medicine has warned of a potential elevated cancer risk among sexual minorities because known risk factors—nulliparity, obesity, smoking, alcohol use—are more common than among heterosexuals. However, national cancer registries do not collect sexual orientation, so there is no way to quantify the magnitude of this burden. Without these data, sexual minorities may continue to be disproportionately burdened by cancers. Longitudinal cohort studies with substantial statistical power and high-quality assessments of sexual orientation and cancer endpoints are the best way to fill this gap. Such studies will provide the empirical evidence needed to develop public health interventions and offer data that are not feasible for cancer registries to collect, such as self-reported dietary intake. This grant's goal is to quantify cancer disparities with longitudinal cohort data and, using a life course framework, gain a nuanced understanding of factors across the lifespan, which may confer different risk in various sexual orientation groups. To address these gaps, we analyzed national data from four longitudinal cohorts: the Nurses' Health Study (NHS) 2 and 3 and the Growing Up Today Study (GUTS) 1 and 2. These cohorts include nearly 200,000 male and female participants, 8% (or nearly 15,000) of whom are sexual minorities, giving ample statistical power. The data span from the prenatal period through adulthood and include detailed sexual orientation measures and biospecimens as well as thousands of cancer cases, including hundreds in sexual minorities. With these data, we can provide more accurate estimates of cancer incidence across sexual orientation groups and a more nuanced understanding of mediating risk factors. The findings will highlight new avenues for health equity and interventions for all people, regardless of sexual orientation.
Citation Format: Brittany Charlton. Using large, prospective cohort data to elucidate sexual orientation-related cancer disparities [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA-13.
Abstract IA-20: The opportunities and challenges of integrating population histories into genetic studies for diverse populations
Authors: Chiang Charleston 
Published: January 2022

Abstract
Genetic factors, together with other environmental and/or social factors, contribute to the risk of diseases in any population. There is a well-recognized need to be more inclusive of diverse populations in genetic studies, but several obstacles continue to exist, including, but not limited to, the difficulty of recruiting individuals from diverse populations in large numbers and the lack of representation in available genomic references. These obstacles notwithstanding, studying diverse populations would provide informative and population-specific insights important for the healthcare management of a population. As an example of an understudied population, the Native Hawaiians have a unique genetic history that can be leveraged to enhance the design and interpretation of genetic studies. It has been shown that the predominant Polynesian genetic ancestry component in Native Hawaiians is associated with elevated risk of cardiometabolic diseases. This finding is consistent with, though not a proof of, the hypothesis that there exist population-enriched genetic variants underlying the risk of these diseases. At the same time, currently available genomic resources underserve the Native Hawaiians due to a lack of representation, such that genetic variants strongly associated with diseases could not be systematically discovered. Therefore, by developing key genomic resources, integrating evolutionary thinking into genetic epidemiology, and partnering with the community, we will have the opportunity to efficiently advance our knowledge of the genetic risk factors, ameliorate health disparity, and improve healthcare in this underserved population.
Citation Format: Charleston Chiang. The opportunities and challenges of integrating population histories into genetic studies for diverse populations [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA-20.
Abstract IA-24: Implicit bias in oncology: Towards a more inclusive workforce
Authors: Tsai Jessica W 
Published: January 2022

Abstract
Implicit bias includes those unconscious attitudes, biases, and stereotypes that shape our behaviors and interactions with others. While implicit biases are known to adversely affect the care of oncology patients, they are also deeply imbued in the culture of our workforce and permit a non-inclusive environment. The consequences of implicit bias are profound, including repeated microaggressions, detraction from academic work, the biased language of evaluation, the cumulative effects of such biases on promotions, and the lack of diversity in leadership positions. Dismantling such a system requires conscious effort rooted in organizational commitment. This session will begin to address these issues by applying a tangible approach to recruitment, highlighting the intentionality of overhauling a recruitment process. Such an approach can be replicated in other settings when grounded in a firm dedication to inclusion and an openness to self-education and self-reflection.
Citation Format: Jessica W Tsai. Implicit bias in oncology: Towards a more inclusive workforce [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA-24.
Abstract IA-49: Facilitators and barriers to implementing low-dose CT screening for lung cancer in a tribal health system
Authors: Nagykáldi Zsolt J. 
Published: January 2022

Abstract
Lung cancer is the leading cause of cancer mortality among American Indians and Alaska Natives (AI/AN), and many AI/AN communities have worse lung cancer incidence rates, survival, and death compared to the general population. Although lung cancer screening (LCS) with low-dose computed tomography is a grade-B USPSTF recommendation, uptake of LCS has been slow in most healthcare systems. LCS implementation among AI/AN has not been studied before in detail. To address this knowledge and implementation gap, a multi-phase, 5-year “Tribally Engaged Approaches to Lung Screening" (TEALS) study was launched in 2019 in partnership with the Choctaw Nation of Oklahoma. The overarching goal of this project is to co-design and test an LCS implementation program. This presentation will discuss what is being learned about potential facilitators and barriers to implementing LCS in a tribal health care setting. Findings may be pertinent to other health systems serving tribal, rural or underserved populations.
Citation Format: Zsolt J. Nagykáldi. Facilitators and barriers to implementing low-dose CT screening for lung cancer in a tribal health system [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA-49.
Abstract IA-51: If not now, then when? Tackling barriers to clinical trials to ensure inclusion of underrepresented minorities
Authors: Sheppard Vanessa B. 
Published: January 2022

Abstract
The low representation of underrepresented minorities in clinical trials is well known. Unfortunately, there appears to be modest progress in the inclusion of these groups in the nearly 30 years since the NIH Revitalization Act of 1993. Racial and ethnic diversity in clinical trials is imperative for ensuring that novel cancer therapies, behavioral interventions and other types of scientific advances reach and are relevant to all population segments. It will be impossible to eliminate disparities and achieve health equity without diversity and inclusion in clinical research. Many barriers exist to clinical trials and some may be exacerbated among racial/ethnic minorities. This presentation will discuss multilevel barriers to participation in clinical research, share engagement principles related to partnerships with African American/Black and Latino/Latinx populations, and provide lessons learned from institutional and investigator led-initiatives. Data sources include chart reviews, patient interviews and surveys. Selected clinical studies will be discussed along with qualitative and quantitative data. The overall goal is to identify actionable steps towards a collective path of improving minority participation in clinical trials. Strategies that optimize opportunities for system change may have greater impact than strategies that focus solely on patient and/or community attitudes or behaviors. Given the COVID-19 pandemic, public awareness about clinical trials may be at a record high. Thus, community conversations about science and the clarion call for social justice may be the energy needed for cancer scientists to collaborate and change the narrative regarding participation of underrepresented minorities in research.
Citation Format: Vanessa B. Sheppard. If not now, then when? Tackling barriers to clinical trials to ensure inclusion of underrepresented minorities [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA-51.
Abstract PO-001: The repository for Caribbean cancer publications (ReCCaP): Database development and publication trends 2004-2019
Authors: Badal Kimberly , Moore Moesha , Thomas Mikhail 
Published: January 2022

Abstract
Objective: In the Caribbean region, research has been limited, making it challenging to find. In order for the region to optimally access and utilize present research and identify gaps, we developed the Repository for Caribbean Cancer Publications (ReCCaP) to home publications on cancer in the Caribbean population and diaspora and report on publication trends. Methods: A systematic PubMed literature search for the period 2004-2019 (15 years) was developed using keywords related to “cancer” and “Caribbean.” Three independent investigators verified included publications. The final database was formatted and hosted in an online database management software. Publication trends over time, by country, cancer type, and income classification were investigated. Results: Of the 4935 publications found, 1194 papers met the inclusion criteria with 803 publications (67.25 %) being on the Caribbean population, 139 publications (11.64%) including multiple Caribbean countries and 252 publications (21.11%) on the diaspora. Between 2004-2019 there was an overall 0.20 increase in publications regionally. Overall, most publications were on breast (n = 168, 14.07%), prostate (n = 156, 13.07%), cervical (n = 152, 12.73%), colorectal (n = 80, 6.70%), and lung cancer (n = 36, 3.02%). The highest number of papers were published by Puerto Rico (22.80 pubs/year), Cuba (8.27 pubs/year), Jamaica (6.27 pubs/year), Trinidad and Tobago (3.53 pubs/year), and Martinique (2.27 pubs/year). The high-income countries (n=10) collectively lead in publications over the 15-year period. Conclusion: ReCCaP provides an easily searchable database highlighting published work and gaps in knowledge on cancer in the Caribbean and diaspora.
Citation Format: Kimberly Badal, Moesha Moore, Mikhail Thomas. The repository for Caribbean cancer publications (ReCCaP): Database development and publication trends 2004-2019 [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-001.
Abstract PO-008: Predictive analysis of demographic factors to examine disparity in gynecologic cancer
Authors: Bahrani-Mostafavi Zahra , Koplas Patricia 
Published: January 2022

Abstract
Introduction: Cancer continues to be a major cause of mortality worldwide and is the leading cause of death for women age 40-79. Gynecologic cancers (GYNC) account for 6.3% of all cancers, making it the 4th leading cause of cancer death among US women. Research has shown that cancers are linked to various demographic factors. Cancer incidence may differ among people of different race/ethnicity due to socioeconomic status; specifically, these variables can impact exposure to risk factors, access to health education, and early detection and treatment. Race/ethnicity is a known risk factor for GYNC. Due to the disparity in the US healthcare system, analysis of the association of various demographic variables with cancer diagnosis in women is imperative to better understand health outcomes for GYNC in this country. Methods: We used the female portion of the 2012 Florida State Inpatient Database of the Healthcare Cost and Utilization Project as our sample. The outcome variable was presence or absence of a cancer diagnosis identified by ICD-9 codes for the following cancers: ovary (OC), uterine (UC), and cervical (CC). Logistic regression analyses examined the patient-level factors of race/ethnicity, age, insurance type, income level, and other comorbidities as potential independent predictors of cancer diagnosis. Results: Logistic regression analysis demonstrated that the odds of CC is increased in women who are black (OR=1.4, 95% CI 1.2-1.5), middle age (OR=5.9, 95% CI 5.1-6.9), and have Medicaid (OR=2.2, 95% CI 3.5-4.9). The similar pattern observed with the OC and UC analysis suggests the presence of cancer disparity among women of lower socioeconomic status. Conclusions: In this study we found that cervical, ovarian, and uterine cancers were significantly associated with variables such as race and lack of reliable health insurance which can indicate disparity. One factor which could potentially contribute to any health disparity in this sample is the lack of ACA Medicaid expansion in Florida. Findings from this study highlight the importance of considering access to healthcare for women from various backgrounds to improve management of cancer and women's health at large.
Citation Format: Zahra Bahrani-Mostafavi, Patricia Koplas. Predictive analysis of demographic factors to examine disparity in gynecologic cancer [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-008.
Abstract PO-054: Evidence-based sexual health education program among at-risk youth baseline findings
Authors: Merceir Ra'Ann , Bhimla Aisha , Duro-Aina Adebola , Tan Yin , Liao Sabrina , Wang Min Qi , Jackson Renee , Ma Grace X. 
Published: January 2022

Abstract
Background: Of the estimated 26 million new diagnosis of sexually transmitted infections (STIs) each year, youth aged 15 – 24yo constitute half of these. The most common STI, Human Papillomavirus (HPV), is the primary cause of cervical, anal, and oropharyngeal cancers. Racial and ethnic minority youth are at increased risk for STIs such as HPV. Lack of access to comprehensive sexual health education leave youth vulnerable to STI's which increase their risk of certain cancers. This study describes characteristics of participants regarding engagement in sexual behaviors and knowledge and attitudes towards STI protection. Methods: Proud-Teens of Philly (PTOP), an evidence-based program, was implemented in youth (n=212) aged 12-19 years in Philadelphia County recruited from a network of partner sites. Program implementation occurred over nine one-hour virtual sessions. The program aimed to reduce risky sexual behaviors by promoting healthy choices and increasing knowledge of sexual health. Participants completed a pre-survey administered online prior to starting the program. Results: Participants' average age was 14.2 years old, 49.2% of participants identified as Hispanic/Latino, and (21.2%) of participants were Non-Hispanic Black, followed by Non-Hispanic white (30.7%). At baseline, 12.8% of participants have been or are currently sexually active, and about half felt strongly about delaying sexual behavior (52.8%). Findings revealed gaps in communication about barrier protection with sexual partners. While 82.0% indicate they agree condoms are effective in preventing STI transmission, there was a low perceived susceptibility of contracting an STI. Conclusion: Findings suggest implementing Proud Teens of Philly may be beneficial in reducing STIs and HPV related cancers among at-risk youth by promoting healthy sexual behaviors.
Citation Format: Ra'Ann Merceir, Aisha Bhimla, Adebola Duro-Aina, Yin Tan, Sabrina Liao, Min Qi Wang, Renee Jackson, Grace X. Ma. Evidence-based sexual health education program among at-risk youth baseline findings [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-054.