bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melan-A expression related to apoptosis of melanocytes in segmental and non-segmental vitiligo
Authors: Setyanto Boedhy , Kalim Handono , Poeranto Sri , Widasmara Dhelya 
Published: October 2022

Background Vitiligo is a progressive depigmentation of the skin with unclear etiology. Cell-mediated immunity has been suggested to play an important role in the pathogenesis of vitiligo’s progression. Melan-A has a high affinity for specific CD8+ T cells and is one of the critical markers for detecting damage to melanocytes. Our study aims to demonstrate the differences in Melan-A expression associated with apoptosis of melanocytes in patients with segmental vitiligo (SV) and those with non-segmental vitiligo (NSV). Methods A cross-sectional study with 64 patients diagnosed with vitiligo, of whom 33 had NSV and 31 had SV. Skin biopsy and direct immunofluorescence were used to examine Melan-A, and the TUNEL staining method was performed to examine melanocyte apoptosis in both groups. Group comparisons were conducted using appropriate statistical methods. Results Melan-A expression was significantly higher in the NSV group than in the SV group, and there was a significant difference between the two groups (p=0.001). The median of melanocyte apoptosis in the NSV group was relatively higher than in the SV group, and a significant difference was found between the two groups (p=0.001). The Spearman’s rank correlation test between Melan-A expression and melanocyte apoptosis in the NSV group was 0.767 (76.7%) and showed a significant relationship (p<0.05). The same test in the SV group was 0.583 (58.3%) and showed a significant relationship (p<0.05). In both groups, the higher the Melan-A expression, the higher the melanocyte apoptosis. Conclusion Melan-A expression and melanocyte apoptosis are positively correlated. Higher Melan-A expression and melanocyte apoptosis in NSV indicates more severe vitiligo disease compared to SV.
Effects of evidence-based clinical practice guidelines for breast cancer in health care quality improvements. A second systematic review.
Authors: Ramírez-Morera Anggie , Tristán Mario , Salazar-Vargas Jordan , Rivera-Chavarría Ana Leonor 
Published: October 2022

Background: Traditionally, EB-CPGs have been believed to mainly improve the quality and consistency of health care, but this claim must be conclusively proven. We used the Donabedian three-dimensional model (structure, process, and patient outcomes) to assess improvements in the quality of medical care derived from implementing EB-CPGs. This study corresponds to the second systematic review carried out as a series of studies on different clinical issues that aim to evaluate the effectiveness of the application of the EB-CPG for improving the quality of care. Methods: We followed the methods described by the Cochrane Handbook and presented a descriptive analysis because of the high heterogeneity found across the included studies. We searched the Cochrane Central Register of Controlled Trials, PubMed, and EBSCO Host databases, as well as the grey literature, between 1990 and April 2021. No language restrictions were applied. Only randomised clinical trials (RCTs) were selected. Results: Of the total of 364 interventions included in the eleven RCTs evaluated, 11 (3%) were related to healthcare structure, 51 (14%) to the healthcare delivery process and 302 (83%) to patient outcomes. Regarding the impact of using the EB-CPGs, in 303 interventions (83%), there were no significant differences between the control and experimental groups. In 4 interventions (1%), the result favoured the control and intervention groups in 57 of the interventions (16%). Conclusions: Our study showed that EB-CPGs slightly enhanced the quality of health care in the three dimensions described by Donabedian. Future RCTs should improve their design and methodological rigour by considering the certainty of the evidence supporting the EB-CPGs recommendations. In that context, broader analyses could be performed, having more concise hypotheses for further research. Registration: PROSPERO CRD42020205594
Laboratory risk factors for mortality in severe and critical COVID-19 patients admitted to the ICU
Authors: Bestari Muhammad Garidya , Suharjo Tommy , Ayu Nuari Lulu , Hadi Faujan Abdul , Panjaitan Lucas Welfried , Bestari Muhammad Begawan 
Published: October 2022

Background: Several studies have reported clinical characteristics and risk factors for predicting adverse outcomes in COVID-19.4–6 However, data exclusively from the ICU especially in the low- and middle-income countries (LMIC) remain lacking. This study aimed to explore risk factors associated with mortality based on laboratory parameters at hospital admission in severe and critical COVID-19 patients admitted to the ICU. Methods: This study is a retrospective cohort study. Data from the electronic medical records were collected retrospectively from all severe and critical COVID-19 patients requiring ICU admission in two designated COVID-19 hospitals in Jakarta, Indonesia. A multivariate logistic regression analysis was used to identify the predictors associated with ICU mortality. The model performance was evaluated by the area under curve (AUC) from the receiver operating characteristic (ROC) analysis. Results: There were 334 patients admitted to the ICU with COVID-19 included in the statistical analysis. The ICU mortality rate was 75.1%, with 251 patients died in the hospital. Independent risk factors associated mortality including white blood cell count >13.9 x109/L (OR=2.41; 95% CI, 1.15-5.06, p=0.02), neutrophil to lymphocyte ratio >10.7 (OR=2.20; 95% CI, 1.20 – 4.03, p=0.011), and creatinine >0.8 mg/dL (OR=3.55; 95% CI, 2.05 – 6.17, p<0.001). The model yielded an AUC of 0.72 (95% CI, 0.659-0.780, p<0.0001) for predicting ICU mortality in severe and critical COVID-19 patients. Conclusions: White blood cell, neutrophil to lymphocyte ratio, and serum creatinine on hospital admission are significant predictors of mortality in severe and critical COVID-19 patients admitted to the ICU. The ICU mortality rate during the second wave of the pandemic in this study was high.
Literatura infantil y lectura dialógica. La formación de educadores desde la investigación
Authors: García-Parejo Isabel 
Published: October 2022

Reseña
Literatura infantil y lectura dialógica. La formación de educadores desde la investigación, por Amando López, Valero, Eduardo Encabo Fernández, Isabel Jerez Martínez y Lourdes Hernández Delgado (2021). Octaedro. 140 págs. ISBN: 978-84-18819-40-7
“The times they are a-changin’”: A longitudinal, mixed methods case study of a hospital transformation
Authors: Pomare Chiara , Gardiner Brett , Ellis Louise A. , Long Janet C. , Churruca Kate , Braithwaite Jeffrey 
Published: October 2022

Background
Changes to hospital infrastructure are inevitable in ever-evolving healthcare systems. The redevelopment of hospitals and opening of new buildings can be a complex and challenging time for staff as they must find ways to deliver safe and high-quality care while navigating the complexities and uncertainties of change. This study explores the perspectives and experiences of staff and patients before and after the opening of a new hospital building as part of a large public hospital redevelopment in Sydney, Australia.

Methods
The study comprised a longitudinal mixed methods case study design. Methods included two rounds of staff surveys (n = 292 participants), two rounds of staff interviews (n = 66), six rounds of patient surveys (n = 255), and analysis of hospital data at tri-monthly intervals over two years. Data were compared before (2019) and after (2020) a new hospital building opened at a publicly funded hospital in Sydney, Australia.

Results
Four key themes and perspectives emerged from the interviews including change uncertainty, communication effectiveness, staffing adequacy and staff resilience. Significant differences in staff perceptions of change readiness over time was identified. Specifically, perceptions that the organisational change was appropriate significantly decreased (2019: 15.93 ± 3.86; 2020: 14.13 ± 3.62; p < .001) and perceptions that staff could deal with the change significantly increased (2019: 17.30 ± 4.77; 2020: 19.16 ± 4.36; p = .001) after the building opened compared to before. Global satisfaction scores from patient survey data showed that patient experience significantly declined after the building opened compared to before (2020: 81.70 ± 21.52; 2019: 84.43 ± 18.46)), t(254) = -64.55, p < 0.05, and improved a few months after opening of the new facilities. This coincided with the improvement in staff perceptions in dealing with the change.

Conclusions
Moving into a new hospital building can be a challenging time for staff and patients. Staff experienced uncertainty and stress, and displayed practices of resilience to deliver patient care during a difficult period of change. Policy makers, hospital managers, staff and patients must work together to minimise disruption to patient care and experience. Key recommendations for future hospital redevelopment projects outline the importance of supporting and informing staff and patients during the opening of a new hospital building.
Strengthening patients’ triage in community pharmacies: A cluster randomised controlled trial to evaluate the clinical impact of a minor ailment service
Authors: Amador-Fernández Noelia , Benrimoj Shalom I. , Olry de Labry Lima Antonio , García-Cárdenas Victoria , Gastelurrutia Miguel Ángel , Berger Jérôme , Baixauli-Fernández Vicente J. , Climent-Catalá María Teresa , Colomer-Molina Vicente , Martínez-Martínez Fernando 
Published: October 2022

Background
Self-perceived minor ailments might conceal other health conditions if patients are not appropriately assisted by health care professionals. The aim of the study was to evaluate the patient-related outcomes of a community pharmacy Minor Ailment Service (MAS) compared to usual pharmacist care (UC).

Methods
A cluster randomised controlled trial was conducted over six months in community pharmacy in the province of Valencia (Spain). Patients seeking care or requesting a product for a minor ailments considered in the study (dermatological problems, gastrointestinal disturbance, pain and upper respiratory tract related symptoms) were included. The intervention consisted of a standardised pharmacist-patient consultation guided by a web-based program using co-developed management protocols and patients’ educational material. Patients were followed up by phone ten days later. Primary clinical outcomes were appropriate medical referral and modification of direct product request. Secondary outcomes were symptom resolution and reconsultation rates.

Results
A total of 808 patients (323 MAS and 485 UC) were recruited in 27 pharmacies of 21 municipalities. Patients visiting MAS pharmacies had higher odds for being referred to a physician (OR = 2.343, CI95% = [1.146–4.792]) and higher reconsultation rates (OR = 1.833, CI95% = [1.151–2.919]) compared to UC. No significant differences between groups were observed for modification of direct product request and symptom resolution.

Conclusions
The use of management protocols through the MAS strengthened the identification of referral criteria such as red flags in patients suffering minor ailments. These patients with symptoms of minor ailments possibly due to more severe illness were to be referred and evaluated by physicians. Results reinforce that MAS increases safety for those patients consulting in community pharmacy for minor ailments.

Trial registration
Trial registration number: ISRCTN17235323. Retrospectively registered 07/05/2021, https://www.isrctn.com/ISRCTN17235323.
Personal continuity of GP care and outpatient specialist visits in people with type 2 diabetes: A cross-sectional survey
Authors: Hansen Anne Helen , Johansen May-Lill 
Published: October 2022

Background
Continuity of care is particularly important for patients with chronic conditions, such as type 2 diabetes (T2D). Continuity is shown to reduce overall health service utilization among people with diabetes, however, evidence about how it relates to the utilization of outpatient specialist services in Norway is lacking. The aim of this study was to investigate continuity of GP care for people with T2D, and its association with the use of outpatient specialist health care services.

Methods
We used e-mail questionnaire data obtained from members of The Norwegian Diabetes Association in 2018. Eligible for analyses were 494 respondents with T2D and at least one GP visit during the previous year. By descriptive statistics and logistic regressions, we studied usual provider continuity (UPC) and duration of the patient-GP relationship and associations of these measures with somatic outpatient specialist visits. Analyses were adjusted for gender, age, education, self-rated health, and diabetes duration.

Results
Mean age was 62.6 years and mean UPC was 0.85 (CI 0.83–0.87). Two thirds of the sample (66.0%) had made all visits to the regular GP during the previous year (full continuity). Among these, 48.1% had made one or more specialist visits during the previous year, compared to 65.2% among those without full continuity. The probability of outpatient specialist visits was significantly lower among participants with full continuity, compared to those without full continuity (Odds Ratio 0.53, Confidence Interval 0.35–0.80). The probability of visiting outpatient specialist services was not associated with duration of the patient-GP relationship.

Conclusions
We conclude that continuity of care, as measured by Usual Provider Continuity, is high and associated with reduced use of somatic outpatient specialist services in people with T2D in Norway. Continuity and its benefits will become increasingly important as the number of older people with diabetes and other chronic diseases increases.
Storytelling Sejarah Melalui Foto Beranotasi: Koleksi Foto PDIKM Padangpanjang
Authors: Fadli M , Hasfera Dian , Zalmi Fadhila Nurul Husna , Gustia Arifah Yenni 
Published: October 2022

Keterbatasan informasi yang tersedia pada koleksi foto di PDIKM Padangpanjang menjadi kendala bagi pengunjung untuk memahami secara sistematis mengenai isi dari photc. Penelitian ini bertujuan untuk mendeskripsikan mengenai kemas ulang informasi foto koleksi di PDIKM Padang Panjang dengan menyusun anotasi informatif pada setiap foto, untuk memudahkan para pengunjung memperoleh informasi terkait dengan sejarah dan kebudayaan Minangkabau. Metode yang digunakan adalah metode kualitatif, dengan teknik pengumpulan data melalui observasi. Hasil penelitian menujukkan: (1) storytelling dapat dilakukan untuk menjelaskan foto melalui penyusunan anotasi pada setiap foto, dan menimbulkan minat belajar sejarah; (2) anotasi foto disusun dengan tahapan klasifikasi, storyline, membuat anotasi, dan kemas ulang informasi. Dengan melakukan kemas ulang informasi tersebut memberikan kemudahan kepada pengunjung PDIKM untuk memperoleh informasi yang kompregensif, sehingga sejarah dapat dipelajari secara menarik dengan metode storytelling foto beranotasi.
Preservasi, Konservasi dan Restorasi Dokumen di Rekso Pustaka
Authors: Christiani Lydia 
Published: October 2022

Penelitian ini bertujuan untuk menelisik proses preservasi, konservasi dan restorasi koleksi dokumen literer milik Mangkunegaran yang dilakukan oleh Rekso Pustaka. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kualitatif dengan pendekatan studi kasus. Pemilihan informan dalam penelitian ini dilakukan dengan menggunakan purposive sampling. Hasil penelitian ini menunjukkan bahwa Rekso Pustaka sebagai lembaga pengelola dokumen literer yang dibentuk oleh Sri KGPAA Mangkunegara IV pada tahun 1867 memiliki fungsi utama untuk menjaga kelestarian dokumen literer (pustaka) milik Mangkunegaran. Dalam menjalankan fungsi utamanya tersebut, Rekso Pustaka melakukan langkah preservasi dengan memanfaatkan jalur kerjasama, baik pada tataran level nasional maupun internasional. Kerjasama nasional dilakukan dengan menggandeng lembaga pemerintah Republik Indonesia seperti Arsip Nasional Republik Indonesis (ANRI) dan Perpustakaan Nasional Republik Indonesia (Perpusnas RI). Sedangkan pada tataran internasional dilakukan dengan menjalin kerjasama dengan perguruan tinggi seperti Cornell University. Berbagai jalinan kerjasama tersebut membantu upaya Rekso Pustaka dalam melestarikan koleksi dokumen literer milik Mangkunegaran baik dalam konteks pelestarian fisik maupun isi dokumen. Pelestarian fisik dokumen dilakukan dengan menggunakan cengkeh dan kapur barus untuk menghindari kerusakan fisik dokumen dari serangga dan hewan pengerat serta memanfaatkaan kertas antara, tissue Jepang serta tempat khusus dari Sirio Black yang diperoleh dari Arsip Nasional Republik Indonesia (ANRI). Sementara pelesterian isi dokumen dilakukan melalui proses transliterasi sebagai bentuk upaya konservasi serta pembuatan mikrofilm sebagai bentuk upaya restorasi. Proses transliterasi dan pembuatan mikrofilm juga dilakukan dengan memanfaatkan jaringan kerjasama yang dilakukan dengan Perpusnas RI dan Cornell University.
Peningkatan Perekonomian Keluarga Melalui Program Bujaya (Buku Jadi Karya) di Perpustakaan Bukuku Guruku Desa Puro Kecamatan Karangmalang Kabupaten Sragen
Authors: Widyastuti Brhillian , Arfa Mecca 
Published: October 2022

Penelitian ini berjudul Peningkatan Perekonomian Keluarga Melalui Program Bujaya (Buku Jadi Karya) di Perpustakaan Bukuku Guruku Desa Puro Kecamatan Karangmalang Kabupaten Sragen. Tujuan dari penelitian ini adalah untuk mengetahui peningkatan perekonomian keluarga melalui program Bujaya (Buku Jadi Karya) di perpustakaan Bukuku Guruku Desa Puro Kecamatan Karangmalang Kabupaten Sragen. Jenis penelitian yang digunakan dalam penelitian ini yaitu penelitian deskriptif kualitatif. Teknik pengumpulan data yang digunakan ini dengan melakukan observasi, wawancara semi terstruktur dan juga studi dokumen. Wawancara dilakukan dengan teknik purposive sampling. Wawancara dilakukan kepada 5 orang informan yang meliputi 2 informan yang merupakan pengelola perpustakaan dan 3 informan yaitu masyarakat Desa Puro. Data yang diperoleh dari wawancara selanjutnya dianalisis menggunakan analisis tematik. Hasil penelitian menunjukkan bahwa peningkatan perekonomian keluarga melalui program Bujaya (Buku Jadi Karya) di Perpustakaan Bukuku Guruku Desa Puro Kecamatan Karangmalang Kabupaten Sragen meliputi: pertama, program Bujaya dalam peningkatan perekonomian keluarga di Desa Puro sebagai sarana untuk meningkatkan keterampilan. Pelatihan keterampilan dapat digunakan masyarakat untuk meningkatkan kemampuan dalam menciptakan suatu produk usaha. Kedua, program Bujaya dalam peningkatan perekonomian keluarga di Desa Puro sebagai sarana dalam menciptakan suatu peluang usaha. Terciptanya usaha pada masyarakat Desa Puro, membuat keluarga yang awalnya tidak memiliki penghasilan, melalui program Bujaya sebagai sarana menciptakan suatu usaha, masyarakat dapat mempunyai penghasilan yang cukup untuk memenuhi kebutuhan perekonomiannya.
Pengelolaan Arsip Desa Kabupaten Rembang dalam Menunjang Pemerintahan Desa
Authors: Suliyati Titiek 
Published: October 2022

Arsip yang tercipta dalam kegiatan pemerintahan desa memerlukan pengelolaan yang baik untuk menunjang pemerintahan desa dan pelayanan kepada masyarakat. Artikel ini merupakan hasil penelitian dan monitoring yang dilakukan di desa-desa di Kabupaten Rembang bekerja sama dengan Dinas Kearsipan dan Perpustakaan Kabupaten Rembang. Penelitian, monitoring dan evaluasi di lakukan di tiga desa di kecamatan Rembang, yaitu Desa Kumendung, Desa Punjulharjo dan Desa Pasar Banggi. Tiga desa ini menjadi sampel untuk penulisan artikel ini karena kondisi kearsipannya mempunyai kemiripan dan permasalahan yang sama. Tujuan penelitian ini adalah untuk mengetahui tentang permasalahan yang dihadapi oleh pemerintah desa dalam pengelolaan arsip desa serta mengetahui kinerja para pegawai desa. Metode yang digunakan dalam penelitian ini adalah metode kualitatif yang diuraikan secara deskriptif. Data kualitatif diperoleh melalui observasi dan wawancara mendalam dengan para perangkat desa yang menangani bidang kearsipan. Selain itu data juga diperoleh melalui studi dokumen dan literatur, yaitu berupa peraturan-peraturan tentang kearsipan, undang-undang kearsipan, kebijakan-kebijakan pemerintah dan buku-buku tentang kearsipan. Proses analisis data dilakukan melalui tahapan reduksi data, penyajian data dan kesimpulan atau verifikasi. Hasil penelitian menunjukkan, bahwa pengelolaan arsip desa secara umum belum maksimal, karena ada beberapa kendala yaitu keterbatasan pengetahuan pegawai desa yang menangani arsip, keterbatasan sarana dan prasarana kearsipan, keterbatasan dana untuk pengelolaan arsip. Manfaat penelitian yaitu memberikan masukan kepada desa tentang pengelolaan arsip yang baik sehingga dapat menunjang pemerintahan desa dan meningkatkan pelayanan kepada masyarakat.
Promosi Perpustakaan Sekolah Menggunakan Powtoon di SMA Hidayatullah Semarang
Authors: Putra Erik Almi , Arfa Mecca 
Published: October 2022

Penelitian ini berjudul Promosi Perpustakaan Sekolah Menggunakan Powtoon di SMA Hidayatullah Semarang. membahas tentang penggunaan Powtoon untuk memperkenalkan perpustakaan sekolah SMA Islam Hidayatullah Semarang dengan cara pembuatan video profil perpustakaan SMA Islam Hidayatullah. Tujuan dari penelitian ini adalah untuk menjadikan Powtoon sebagai salah satu sarana media untuk mempromosikan perpustakaan sekolah di SMA Islam Hidayatullah Semarang. Jenis dari penelitian ini menggunakan pendekatan kualitatif dengan metode action research. Metode pengumpulan data yang digunakan adalah observasi, wawancara, dan studi pustaka. Tahap yang pertama dilakukan yaitu peneliti melakukan perancangan video profil perpustakaan SMA Islam Hidayatullah dengan mengumpulkan ide bersama dengan pustakawan. Setelah itu peneliti memulai ke tahap pembuatan video profil perpustakaan SMA Islam Hidayatullah dengan patokan kepada ide yang telah didiskusikan bersama pustakawan. Setelah selesai dalam tahap pembuatan video profil perpustakaan SMA Islam Hidayatullah peneliti menampilkan video profil perpustakaan SMA Islam Hidayatullah melalui Powtoon . tahap terakhir peneliti melakukan wawancara secara acak sebanyak sepuluh orang kepada siswa yang berada di kelas, hasil wawancara ini menunjukkan bahwa penggunaan media Powtoon dalam kegiatan promosi perpustakaan dapat diterima oleh siswa SMA Islam Hidayatullah. Ada beberapa kritikan dan masukan dari hasil wawancara bersama pemustaka yang membuat peneliti mengambil kesimpulan bahwa promosi perpustakaan SMA Islam Hidayatullah menggunakan Powtoon sebaiknya diperbaiki sebelum video profil perpustakaan SMA Islam Hidayatullah tersebut diupload di internet.