bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of 434 dogs with non‐steroidal anti‐inflammatory drug toxicosis treated with fluid therapy, lipid emulsion, or therapeutic plasma exchange
Authors: Chalifoux Nolan V. , Butty Emmanuelle M. , Mauro Katie D. , Moyle Rachel B. , Ehrhardt Caryn M. , Robertson James B. , Labato Mary A. , Culler Christine A. , Londoño Leonel A. , Vigani Alessio , Ueda Yu , Suter Steven E. , Lynch Alex M. 
Published: December 2022

AbstractBackgroundTraditional management of non‐steroidal anti‐inflammatory drug (NSAID) intoxication includes gastrointestinal decontamination, intravenous administration of fluids (IVF), and gastroprotection. Intravenous administration of lipid emulsion (ILE) and therapeutic plasma exchange (TPE) are popular novel therapeutic strategies.HypothesisCompare outcomes of dogs treated with IVF, ILE, and TPE for NSAID intoxications and evaluate outcome predictors for drug subgroups.AnimalsFour hundred thirty‐four dogs with NSAID intoxications (2015‐2020).MethodsMulticenter retrospective study of ibuprofen, carprofen, and naproxen intoxication. An ordinal outcome was defined as mild gastrointestinal, moderate kidney, or signs of severe central nervous system disease.ResultsSigns of neurological disease were overrepresented and acute kidney injury underrepresented in the TPE group among dogs exposed to kidney‐ or CNS‐toxic doses (P = .05), though all TPE dogs with signs of neurological disease had evidence of neurotoxicity at presentation. Dogs treated with IVF had a higher maximal creatinine concentration (median, 1.1 mg/dL; range, 0.4‐8.44 mg/dL) compared with IVF + ILE (median, 0.9 mg/dL; range, 0.4‐6.2 mg/dL;P = .01). Increased maximum time to presentation (P < .001), higher baseline creatinine (P < .001) and PCV (P = .007), and absence of induced emesis (P < .001) were associated with greater clinical severity. Ibuprofen toxicosis was associated with more severe clinical signs compared with carprofen (P = .03). Overall survival rate was 99%.Conclusions and Clinical ImportanceNSAID toxicosis generally carries an excellent prognosis in dogs. Despite similar outcomes of lower incidence of AKI in the TPE group, and slightly lower maximal creatinine concentration in dogs treated with ILE vs IVF alone, ILE and TPE should be considered in the management of severe NSAID toxicosis.
Implicit Learning in Production: Productive Generalization of New Form–Meaning Connections in the Absence of Awareness
Authors: Bovolenta Giulia , Williams John N. 
Published: December 2022

AbstractSecond language implicit learning research has shown that a variety of linguistic features can be acquired without awareness. However, this research overwhelmingly uses comprehension tests to measure implicit learning. It remains unclear whether newly acquired implicit knowledge can also be recruited for production. To address this question, we developed a novel paradigm based on elicited recall and false memory that was used to both train participants and test their implicit knowledge in production, including generating new instances of the rule. Participants learned a semiartificial language containing a rule based on one in a natural language (the alternation between Czech spatial prepositionsvandna). Participants who remained unaware of the rule, as assessed by verbal report, nevertheless were able to use it in a production test involving novel items, while believing that they were performing a cued recall test. Even without extensive training, newly acquired implicit knowledge can immediately be evident in production.
Issues in Uyghur phonology
Authors: Mayer Connor , McCollum Adam , Eziz Gülnar 
Published: December 2022

AbstractThis article presents an overview of several significant aspects of the phonology of Uyghur (ISO: uig; pronounced [ʊjˈʁʊr]; Turkic: China). In addition to summarising previous research, we present new data and highlight its relevance for phonological theory. The paper focuses primarily on the processes of backness harmony, rounding harmony, and vowel reduction. Particular attention is paid to the complex, and sometimes opaque, interactions between these processes, as well as the role of phonological exceptionality.
Length‐weight relationships of 12 dominant fish species from a Ramsar Wetland in India: Vembanad Lake
Authors: Roshni Kuttanelloor , Renjithkumar Chelapurath Radhakrishnan 
Published: December 2022

AbstractThe present study describes the length‐weight relationships (LWRs) of 12 dominant finfish species from Vembanad Lake, India, from June 2015 to May 2016. Samples were carried out using a wide range of fishing gears such as gill nets (mesh sizes 20–60 mm), seine nets (mesh sizes 8–16 mm), cast nets (mesh sizes 6–8 mm) and hook and lines. The values of the exponent b ranged from 2.506 (Glossogobius giuris) to 3.305 (Heteropneustes fossilis) and regression parameters R2 from .960 (Carinotetraodon travancoricus) to .995 (G. giuris). The study reports the new maximum total length (TLmax) for Hyporhamphus xanthopterus and first reference regarding length‐weight relationships for Mystus oculatus, Ompok malabaricus and C. travancoricus. The results provide useful information for preparing sustainable resource management plans and conservation strategies for these species in the lake and similar ecosystems.
Analysis of the daylight fireball of July 15, 2021, leading to a meteorite fall and find near Antonin, Poland, and a description of the recovered chondrite
Authors: Shrbený Lukáš , Krzesińska Agata M. , Borovička Jiří , Spurný Pavel , Tymiński Zbigniew , Kmieciak Kryspin 
Published: December 2022

AbstractWe present the description of an observation of a fireball recorded during the sunrise on July 15, 2021. Atmospheric trajectory, impact area, and heliocentric orbit were determined on the basis of three instrumental video records. The terminal part of the fireball was not instrumentally recorded due to clouds. Based on our computations, one meteorite was found in the predicted impact area by Polish searchers. The specimen was, soon after recovery, analyzed for the presence of short‐lived radionuclides and the measurement confirms a very fresh fall, coinciding with the time of the fireball event. The recovered meteorite, Antonin, is an unbrecciated L5 chondrite with shock stage S3, weathering grade W0, and bulk density of 3.42 g cm−3. Unusual for L chondrites, it contains assemblages composed of metal and two sulfides, troilite and mackinawite. We interpret these assemblages to have been formed as products of shock metamorphism and post‐shock annealing on the parent body. This suggests that the thermal and collisional history of the Antonin parent body was complex.
Shikonin enhances chemosensitivity of oral cancer through β‐catenin pathway
Authors: Xiang Yang , Si Lujie , Zheng Ying , Wang Huiming 
Published: December 2022

AbstractObjectivesThis study concentrates on exploring the synergistic effect of shikonin on cisplatin against oral cancer.MethodsTo analyze the IC50 value of shikonin, gradient concentrations of shikonin were added to the oral cancer cell culture medium. After the cisplatin‐resistant cell line was established, the effects of cisplatin and shikonin on the survival rate, proliferation, apoptosis and related pathway protein expression of common/drug‐resistant oral cancer cells were compared through MTT, clone formation, flow cytometry, and Western blot experiments. β‐catenin, which had the most significant expression changes, was overexpressed and silenced, and used to design a reverse validation.ResultsShikonin inhibited the viability of oral cancer cells. Although cisplatin killed some cancer cells, its effect on drug‐resistant cancer cells was significantly reduced. The addition of shikonin enhanced the sensitivity of drug‐resistant cells to cisplatin. Shikonin regulated key proteins in cell proliferation and apoptosis‐related pathways. Among them, shikonin generated the most evident inhibitory effect on β‐catenin. Therefore, β‐catenin overexpression plasmid/siβ‐catenin was transfected into the cells. Silenced β‐catenin was found to reinforce the damaging effect of cisplatin on cancer cells, and overexpressed β‐catenin reversed the effect of shikonin.ConclusionBy down‐regulating β‐catenin expression, shikonin improves the sensitivity of drug‐resistant oral cancer cells to cisplatin.
Histone acetyltransferase HAM1 interacts with molecular chaperone DNAJA2 and confers immune responses through salicylic acid biosynthetic genes in cassava
Authors: Zhao Huiping , Ge Zhongyuan , Zhou Mengmeng , Bai Ruoyu , Zeng Hongqiu , Wei Yunxie , He Chaozu , Shi Haitao 
Published: December 2022

AbstractCassava bacterial blight (CBB) is one of the most serious diseases in cassava production, so it is essential to explore the underlying mechanism of immune responses. Histone acetylation is an important epigenetic modification, however, its relationship with cassava disease resistance remains unclear. Here, we identified 10 histone acetyltransferases in cassava and found that the transcript of MeHAM1 showed the highest induction to CBB. Functional analysis showed that MeHAM1 positively regulated disease resistance to CBB through modulation of salicylic acid (SA) accumulation. Further investigation revealed that MeHAM1 directly activated SA biosynthetic genes’ expression via promoting lysine 9 of histone 3 (H3K9) acetylation and lysine 5 of histone 4 (H4K5) acetylation of these genes. In addition, molecular chaperone MeDNAJA2 physically interacted with MeHAM1, and MeDNAJA2 also regulated plant immune responses and SA biosynthetic genes. In conclusion, this study illustrates that MeHAM1 and MeDNAJA2 confer immune responses through transcriptional programming of SA biosynthetic genes via histone acetylation. The MeHAM1 & MeDNAJA2‐SA biosynthesis module not only constructs the direct relationship between histone acetylation and cassava disease resistance, but also provides gene network with potential value for genetic improvement of cassava disease resistance.
Effective treatment of diabetes, improved quality of life and accelerated cognitive development after pancreas transplantation in a child with type 1 diabetes and allergy to manufactured insulin preparations
Authors: Adamusiak Anna Maria , Ramanathan Karthik , Moe Tracy , Bellin Melena D. , Kandaswamy Raja 
Published: December 2022

AbstractBackgroundInsulin hypersensitivity reactions are rare but serious and significantly affect the treatment of diabetes in children.MethodsA 13‐year‐old girl with type 1 diabetes, hypoglycemic unawareness, and treatment refractory allergy to available insulin preparations underwent a solitary pancreas transplant. Before the pancreas transplantation, she was receiving a continuous subcutaneous infusion of rapid‐acting insulin with an increasing need for antihistamines and steroids, negatively impacting her cognitive and social development. Her diabetes was poorly controlled, and her quality of life was progressively worsening.ResultsFollowing the transplant, she recovered well from surgery and achieved euglycemia without needing exogenous insulin. She had two biopsy proven episodes of acute cellular rejection, successfully treated. Her cognitive development also accelerated. Notable improvement was noted both in her personal quality of life and her family's overall well‐being.ConclusionsThis is the youngest pancreas transplant recipient with over 1‐year graft survival reported in the literature. Pancreas transplant alone in a teenager without indications for kidney transplantation could be considered a last resort treatment for diabetes when continuing insulin therapy presents a high level of morbidity. A pancreas transplant is a feasible treatment modality for patients with refractory insulin allergy.
Susceptibility of fig cultivars to Diaporthe canker in Iran
Authors: Bolboli Zeinab , Mostowfizadeh‐Ghalamfarsa Reza , Jafari Moslem , Sarkhosh Ali 
Published: December 2022

AbstractFig canker is a serious concern in the major fig‐growing region of Iran, Fars Province. The disease reduces yield and the lifespan of fig trees, particularly the dominant commercial dried fig cultivar, Sabz. Four consecutive years of surveys (2019–2022) led to the identification of four distinct canker types (A–D) in infected fig orchards in southern Iran. Morphological identification and multiple gene phylogenetic analyses indicated that 218 (>66% of the total) isolates from infected fig cultivars belonged to Diaporthe cinerascens, all of which were recovered from Type A cankers, that is, trunk cankers with zonation. Based on scales developed by the principal component analysis (PCA) approach of pathogenicity characteristics, D. cinerascens isolates were clustered into three groups: low, moderate and highly aggressive. The susceptibility of 10 drought and/or salinity‐tolerant fig cultivars to a highly aggressive D. cinerascens isolate was evaluated based on five pathogenicity characteristics. These cultivars were clustered into nonsusceptible (cultivar Matti), semisusceptible (the majority of the cultivars) and susceptible (cultivars Dehdez and Gilasi). The present study is the first attempt to assess the response of fig cultivars to the most significant and common pathogen causing fig canker, D. cinerascens, by phenotyping techniques.
Repronormativity in cisgender men's reasons why they would not use womb transplant technology to become pregnant
Authors: Mary‐Jane Jace Mavuso Jabulile 
Published: December 2022

AbstractMuch reproductive scholarship presumes that cisgender men do not wish to become pregnant. And within scholarly discussions on womb transplant technology in particular, cis men's desires to be pregnant are constructed as ‘insubstantial’, and cis men are positioned as neither desiring nor requiring womb transplant technology. Repronormativity, including the assumption that pregnancy and gestational desire are antithetical to cis masculinity/manhood, underpins both bodies of work. As part of a study that sought to visibilise, and analyse narratives of, cis men's desires to be pregnant and/or gestational parents, six cis men were asked whether they would use womb transplant technology to enable their pregnancy if womb transplant technology included men as recipients. The majority of participants said they would not do so, giving different reasons. Using a narrative‐discursive approach to analyse their responses, I argue that their varied responses disrupt and re‐circulate normative discourses on sex/gender, pregnancy, parenthood, and (assisted) reproduction. Ultimately, their varied reasons trouble the normative assumption that cis men do not want to be pregnant and would not take up the opportunity to do so, because they are men.
Serological and molecular characterisation of the most prevalent weak D variants in Croatian population
Authors: Stanic Hana Safic , Galic Zrinka Kruhonja , Dogic Vesna , Bingulac‐Popovic Jasna , Jukic Irena 
Published: December 2022

AbstractIntroductionExistence of hundreds ofRHDgene variants contributes to variable D antigen expression and inconsistencies in reporting theRHDresults. The aim of the study was to determine the serological and molecular characteristics of the most prevalentRHDalleles encoding serologically weak D variants.Material and MethodsBlood donors (n = 145 924) were typed for D antigen using the direct serologic micromethod. Nonreactive samples were analysed in IAT method with the IgM/IgG anti‐D monoclonal blend, and 0,2% (n = 263) confirmed weak D antigen expression. After genomic DNA extraction (Qiaqen, Germany),RHDgenotyping was performed usingin housereagents and PCR‐SSP kits (Inno‐Train, Germany).ResultsThe prevalence of serologically weak D in blood donor population was 0.2% (n = 263).RHDgenotyping confirmed weak D allele in 92.4% and partial D allele in 7.6%. The most common was weak D type 1 (49.7%) followed by weak D type 3 (24.7%) and type 2 (9.5%). Relatively high frequency was detected for weak D type 14 (4.6%) and type 64 (2.3%). In the category of partial D phenotypes, only DVI variant was found. Direct typing has shown great variability in the strength of reactions with different clones of anti‐D reagents.ConclusionWeak D type 1 is the most common weak D variant in Croatian blood donor population. The frequency of D variants and distribution of Rh phenotypes in our study was in concordance with other studies. It has been shown that serological methods and the combination of clones used, cannot distinguish variant D types, which justifies the use of molecular methods.
Simulation of Heat and Mass Transfer in Pulverized Coal Boiler Based on Gaseous Combustion Through Phase Separation Technique
Authors: Ma Gui-Yang , Wan Guang-Zhong , Li Yang , Chen Hong-Wei , Zhang Shan-Shan 
Published: December 2022

Abstract
In order to meet the current environmental protection ultra-low pollutant emission requirements, one-step combustion is changed into two-step combustion by split-phase gasification combustion technology, and double-furnace structure, graded air distribution, calcium injection desulfurization, and combined denitrification with selective non-catalytic reduction (SNCR) and selective catalytic reduction (SCR) are adopted to reduce pollutant emissions. ansys was used to establish a two-dimensional steady-state structure model of pulverized coal boiler with a double-furnace. Finite element analysis was carried out on the combustion in 54 MW, 56 MW, and 58 MW working conditions under different calcium-sulfur (Ca/S) ratios. The results showed that the desulfurization efficiency increased gradually when the Ca/S ratio was between 1.0 and 2.6 under the three working conditions. The desulfurization efficiency has no noticeable change when it is between 2.6 and 2.8, and begins to decline when it is greater than 2.8. The optimal calcium-sulfur ratio is obtained when the calcium-sulfur ratio is 2.6, and the SO2 concentration at the outlet of the furnace is reduced to 0.0001 mg/m3. By controlling the highest temperature in the furnace and adjusting the amount of denitrification agent, the nitrogen oxide emission at the outlet of the furnace is reduced to 0.87 mg/m3.
Printability and Overall Cooling Performance of Additively Manufactured Holes With Inlet and Exit Rounding
Authors: Veley Emma M. , Thole Karen A. , Furgeson Michael T. , Bogard David G. 
Published: December 2022

Abstract
To improve cooling effectiveness of gas turbine hardware, various film cooling hole shapes have previously been researched. Unique design modifications have recently been made possible through the design freedom allotted by additive manufacturing (AM). As one example, creating a rounded inlet for a film-cooling hole can mitigate separation at the inlet. This study explores various geometric features by exploiting the uses of additive manufacturing for shaped film cooling holes at engine scale. Both printability and cooling performance were evaluated. Resulting from this study, additively manufactured holes with hole inlet and exit rounding were printed with some variations from the design intent (DI). The largest deviations from the design intent occurred from dross roughness features located on the leeward side of the hole inlet. The measured overall effectiveness indicated that an as-built inlet fillet decreased in-hole convection as well as decreased jet mixing compared to the as-built sharp inlet. Including an exit fillet, which prevented an overbuilt diffuser exit, was also found to decrease jet mixing. A particular insight gained from this study is the importance of the convective cooling within the hole to the overall cooling performance. In-hole roughness, which is a result of additive manufacturing, increased convective cooling within the holes but also increased jet mixing as the coolant exited the hole. The increased jet mixing caused low overall effectiveness downstream of injection.
Evaluation of Adjoint-Optimized Holes—Part I Baseline Performance
Authors: Gutierrez Daniel , Yoon Christopher , Furgeson Michael T. , Veley Emma M. , Bogard David G. , Thole Karen A. 
Published: December 2022

Abstract
With the advent of the use of additive manufacturing to build gas turbine components, the design space for new hole geometries is essentially unlimited. Recently, a computational adjoint-based optimization method was used to design shaped film cooling holes fed by internal co-flow and cross-flow channels. The associated Reynolds-averaged Navier–Stokes computations predicted that the holes optimized for use with cross-flow (X-AOpt) and co-flow (Co-AOpt) would significantly increase adiabatic effectiveness. However, only the X-AOpt hole was tested experimentally in this previous study. Though the experimentally measured performance for this hole was much less than computationally predicted, it still had a 75% improved performance compared to the conventional 7-7-7-shaped hole. In the current study, the X-AOpt and Co-AOpt-shaped holes were experimentally evaluated using measurements of adiabatic effectiveness and overall cooling effectiveness. Coolant was fed to the holes with an internal co-flow channel. For reference, experiments were also conducted with the baseline 7-7-7-shaped hole, and a 15-15-1-shaped hole (shown in a previous study to be the optimum expansion angles for a shaped hole). Furthermore, overall cooling effectiveness measurements were made with engine-scale models to evaluate the performance of additively manufactured (AM) X-AOpt and Co-AOpt holes with a realistic metal build. Results from this study confirmed that the X-AOpt hole had a 75% increase in adiabatic effectiveness compared to the 7-7-7-shaped hole. However, the Co-AOpt hole had only a 30% increase in adiabatic effectiveness, substantially less than had been computationally predicted. Measurements of overall cooling effectiveness for the engine-scale models and the large-scale models followed similar trends.
Chest compressions in newborn infants: a scoping review
Authors: Ramachandran Shalini , Bruckner Marlies , Wyckoff Myra H , Schmölzer Georg M 
Published: December 2022

AimThe International Liaison Committee on Resuscitation Neonatal Life Support Task Force undertook a scoping review of the literature to identify evidence relating to neonatal cardiopulmonary resuscitation.MethodsMEDLINE complete, EMBASE and Cochrane database of Systematic reviews were searched from inception to November 2021. Two authors screened titles and abstracts and full text reviewed. Studies were eligible for inclusion if they were peer-reviewed and assessed one of five aspects of chest compression in the newborn infant including: (1) heart rate thresholds to start chest compressions (CC), (2) compression to ventilation ratio (C:V ratio), (3) CC technique, (4) oxygen use during CC and 5) feedback devices to optimise CC.ResultsSeventy-four studies were included (n=46 simulation, n=24 animal and n=4 clinical studies); 22/74 were related to compression to ventilation ratios, 29/74 examined optimal technique to perform CC, 7/74 examined oxygen delivery and 15/74 described feedback devices during neonatal CC.ConclusionThere were very few clinical studies and mostly manikin and animal studies. The findings either reinforced or were insufficient to change previous recommendations which included to start CC if heart rate remains <60/min despite adequate ventilation, using a 3:1 C:V ratio, the two-thumb encircling technique and 100% oxygen during CC.