bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated artificial intelligence‐based system for clinical follow‐up of patients with age‐related macular degeneration
Authors: Potapenko Ivan , Thiesson Bo , Kristensen Mads , Hajari Javad Nouri , Ilginis Tomas , Fuchs Josefine , Hamann Steffen , la Cour Morten 
Published: March 2022

AbstractPurposeIn this study, we investigate the potential of a novel artificial intelligence‐based system for autonomous follow‐up of patients treated for neovascular age‐related macular degeneration (AMD).MethodsA temporal deep learning model was trained on a data set of 84 489 optical coherence tomography scans from AMD patients to recognize disease activity, and its performance was compared with a published non‐temporal model trained on the same data (Acta Ophthalmol, 2021). An autonomous follow‐up system was created by augmenting the AI model with deterministic logic to suggest treatment according to the observe‐and‐plan regimen. To validate the AI‐based system, a data set comprising clinical decisions and imaging data from 200 follow‐up consultations was collected prospectively. In each case, both the autonomous AI decision and original clinical decision were compared with an expert panel consensus.ResultsThe temporal AI model proved superior at detecting disease activity compared with the model without temporal input (area under the curve 0.900 (95% CI 0.894–0.906) and 0.857 (95% CI 0.846–0.867) respectively). The AI‐based follow‐up system could make an autonomous decision in 73% of the cases, 91.8% of which were in agreement with expert consensus. This was on par with the 87.7% agreement rate between decisions made in the clinic and expert consensus (p = 0.33).ConclusionsThe proposed autonomous follow‐up system was shown to be safe and compliant with expert consensus on par with clinical practice. The system could in the future ease the pressure on public ophthalmology services from an increasing number of AMD patients.
Heritability of retinal drusen in the Copenhagen Twin Cohort Eye Study
Authors: Belmouhand Mohamed , Rothenbuehler Simon Paul , Hjelmborg Jacob B. , Dabbah Sami , Bjerager Jakob , Sander Birgit Agnes , Dalgård Christine , Larsen Michael 
Published: March 2022

AbstractPurposeTo study age‐ and sex‐adjusted heritability of small hard drusen and early age‐related macular degeneration (AMD) in a population‐based twin cohort.MethodsThis was a single‐centre, cross‐sectional, classical twin study with ophthalmic examination including refraction, biometry, best‐corrected visual acuity assessment, colour and autofluorescence fundus photography, and fundus optical coherence tomography. Grading and categorization of drusen was by diameter and location.ResultsThe study enrolled 176 same‐sex pairs of twins of mean (SD) age 58.6 (9.9) years. The prevalence of the four phenotypes ≥20 small hard macular drusen (largest diameter < 63 μm), ≥20 small hard extramacular drusen, intermediate drusen (63–125 μm) anywhere, and large drusen (>125 μm) anywhere was 12.4%, 36.4%, 5.8%, and 8.4%, respectively, and the respective heritabilities, adjusted for age and sex, were 78.2% [73.5–82.9], 69.1% [62.3–75.9], 30.1% [4.1–56.1], and 65.6% [26.4–100]. Age trajectory analysis supported a gradual transition to larger numbers of small hard drusen with increasing age. The heritability of ≥20 small hard drusen was markedly lower than the 99% found in the 40% overlapping twin cohort that was seen 20 years earlier.ConclusionNumerous (≥20) small hard drusen and larger drusen that fit the definition of dry AMD were highly heritable. Small hard drusen counts increased with age. Decreasing heritability with increasing age suggests that the impact of behavioural and environmental factors on the development of small hard drusen increases with age.
Concurrent robot‐assisted radical prostatectomy and robot‐assisted partial nephrectomy for patients with synchronous prostate cancer and small renal tumor: A case series of five patients
Authors: Kanehira Mitsugu , Tamura Daichi , Matsuura Tomohiko , Maekawa Shigekatsu , Kato Renpei , Kato Yoichiro , Takata Ryo , Obara Wataru 
Published: March 2022

AbstractRobotic surgery has become widely used in the field of urology. We experienced concurrent robot‐assisted radical prostatectomy (RARP) and robot‐assisted partial nephrectomy (RAPN) for the complex cases of synchronous primary cancers. Concurrent RARP and RAPN with horseshoe kidney have not been reported to date. Mean operative time was 398.6 minutes and mean total console time was 259.6 minutes. Total mean estimated blood loss was 313.4 mL. None of the patients required conversion to open surgery, none needed blood transfusion, and no perioperative complications occurred. The mean estimated glomerular filtration rate at 1 month postoperatively was maintained compared to pre‐operative value. Positive surgical margin was shown in one patient with RARP. Concurrent RARP and RAPN using reusable ports can be safely performed. This combined surgery may be considered one of the treatment choices for synchronous prostate cancer and small renal tumor.
Changes in suspected adverse drug reaction reporting via the yellow card scheme in Wales following the introduction of a National Reporting Indicator
Authors: Deslandes Paul N. , Bracchi Robert , Jones Karen , Haines Kath E. , Carey Emma , Adams Alana , Walker Jenna , Thomas Alison , Routledge Philip A. 
Published: March 2022

AimsThis study aimed to assess the impact of a National Reporting Indicator (NRI) on rates of reporting of suspected adverse drug reactions using the Yellow Card scheme following the introduction of the NRI in Wales (UK) in April 2014.MethodsYellow Card reporting data for general practitioners and other reporting groups in Wales and England for the financial years 2014–15 (study period 1) and 2015–16 (study period 2) were obtained from the Medicines and Healthcare Products Regulatory Agency and compared with those for 2013–14 (pre‐NRI control period).ResultsThe numbers of Yellow Cards submitted by general practitioners in Wales were 271, 665 and 870 in the control period, study period 1 and study period 2, respectively. This is equivalent to an increase of 145% in study period 1 and 221% in study period 2 compared with the 12‐month control period (2013–14). Corresponding increases in England were 17% and 37%, respectively (P < .001 chi–squared test). The numbers of Yellow Cards submitted by other groups in Wales were 906, 795 and 947 in each of the study periods.ConclusionsIntroduction of the NRI corresponded with a significant increase in the number of Yellow Cards submitted by general practitioners in Wales. General practitioner reporting rates continued to increase year on year through to 2018–19 with the NRI still in place. No concomitant change was found in reporting rates by other groups in the health boards in Wales.
Cardiovascular drugs and COVID‐19 clinical outcomes: a systematic review and meta‐analysis of randomized controlled trials
Authors: Asiimwe Innocent G. , Pushpakom Sudeep P. , Turner Richard M. , Kolamunnage‐Dona Ruwanthi , Jorgensen Andrea L. , Pirmohamed Munir 
Published: March 2022

Aims: To update our previously reported systematic review and meta‐analysis of observational studies on cardiovascular drug exposure and COVID‐19 clinical outcomes by focusing on newly published randomized controlled trials (RCTs).Methods: More than 500 databases were searched between 1 November 2020 and 2 October 2021 to identify RCTs that were published after our baseline review. One reviewer extracted data with other reviewers verifying the extracted data for accuracy and completeness.Results: After screening 22 414 records, we included 24 and 21 RCTs in the qualitative and quantitative syntheses, respectively. The most investigated drug classes were angiotensin‐converting enzyme inhibitors (ACEIs)/angiotensin receptor blocker (ARBs) and anticoagulants, investigated by 10 and 11 studies respectively. In meta‐analyses, ACEI/ARBs did not affect hospitalization length (mean difference −0.42, 95% confidence interval [CI] −1.83; 0.98 d, n = 1183), COVID‐19 severity (risk ratio/RR 0.90, 95% CI 0.71; 1.15, n = 1661) or mortality (risk ratio [RR] 0.92, 95% CI 0.58; 1.47, n = 1646). Therapeutic anticoagulation also had no effect (hospitalization length mean difference −0.29, 95% CI −1.13 to 0.56 d, n = 1449; severity RR 0.86, 95% CI 0.70; 1.04, n = 2696; and, mortality RR 0.93, 95% CI 0.77; 1.13, n = 5689). Other investigated drug classes were antiplatelets (aspirin, 2 trials), antithrombotics (sulodexide, 1 trial), calcium channel blockers (amlodipine, 1 trial) and lipid‐modifying drugs (atorvastatin, 1 trial).Conclusion: Moderate‐ to high‐certainty RCT evidence suggests that cardiovascular drugs such as ACEIs/ARBs are not associated with poor COVID‐19 outcomes, and should therefore not be discontinued. These cardiovascular drugs should also not be initiated to treat or prevent COVID‐19 unless they are needed for an underlying currently approved therapeutic indication.
Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative
Authors: Burdick Katherine E. , Millett Caitlin E. , Yocum Anastasia K. , Altimus Cara M. , Andreassen Ole A. , Aubin Valerie , Belzeaux Raoul , Berk Michael , Biernacka Joanna M. , Blumberg Hilary P. , Cleare Anthony J. , Diaz‐Byrd Claudia , Dubertret Caroline , Etain Bruno , Eyler Lisa T. , Forester Brent P. , Fullerton Janice M. , Frye Mark A. , Gard Sébastien , Godin Ophelia , Haffen Emmanuel , Klaus Federica , Lagerberg Trine Vik , Leboyer Marion , Martinez‐Aran Anabel , McElroy Susan , Mitchell Philip B. , Olie Emilie , Olorunfemi Phebe , Passerieux Christine , Peters Amy T. , Pham Daniel L. , Polosan Mircea , Potter Julia R. , Sajatovic Martha , Samalin Ludovic , Schwan Raymund , Shanahan Megan , Solé Brisa , Strawbridge Rebecca , Stuart Amanda L. , Torres Ivan , Ueland Torrill , Vieta Eduard , Williams Lana J. , Wrobel Anna L. , Yatham Lakshmi N. , Young Allan H. , Nierenberg Andrew A. , McInnis Melvin G. 
Published: March 2022

AbstractObjectivesPersistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community function in multiple cohorts of well‐characterized samples of individuals with BD.MethodsThirteen cohorts from 7 countries included n = 5882 individuals with BD across multiple sites. The statistical approach consisted of a systematic uniform application of analyses across sites. Each site performed a logistic regression analysis with empirically derived “higher versus lower function” as the dependent variable and selected clinical and demographic variables as predictors.ResultsWe found high rates of functional impairment, ranging from 41 to 75%. Lower community functioning was associated with depressive symptoms in 10 of 12 of the cohorts that included this variable in the analysis. Lower levels of education, a greater number of prior mood episodes, the presence of a comorbid substance use disorder, and a greater total number of psychotropic medications were also associated with low functioning.ConclusionsThe bipolar clinical research community is poised to work together to characterize the multi‐dimensional contributors to impairment and address the barriers that impede patients' complete recovery. We must also identify the core features which enable many to thrive and live successfully with BD. A large‐scale, worldwide, prospective longitudinal study focused squarely on BD and its heterogeneous presentations will serve as a platform for discovery and promote major advances toward optimizing outcomes for every individual with this illness.
Walking the talk about corporate social responsibility communication: An elaboration likelihood model perspective
Authors: Camilleri Mark Anthony 
Published: March 2022

AbstractLarge organizations, including listed businesses, financial service providers as well as public services entities are increasingly disclosing information on their environmental, social and governance (ESG) issues through corporate websites or via social media. Therefore, this research uses valid measures from the Elaboration Likelihood Model (ELM) to explore the individuals’ attitudes toward online corporate social responsibility (CSR) communications. The data were gathered from a structured questionnaire among three hundred ninety‐two respondents (n = 392). A structural equations modeling partial least squares (SEM‐PLS 3) approach was used to analyze the data. The findings revealed that the timeliness, relevance and accuracy of information as well as the source expertise were highly significant antecedents that were affecting the research participants’ attitudes toward CSR communications. This contribution implies that there is scope for content curators to publish quality online information on their business activities to improve their trustworthiness and positive credentials among stakeholders.
Examining the relationship between negative media coverage and corporate social responsibility
Authors: Pan Xin , Chen Xuanjin , Yang Xue 
Published: March 2022

AbstractThis study investigates the relationship between negative media coverage and corporate social responsibility (CSR). We suggest that CSR can compensate for the loss of legitimacy in a firm only when it receives negative media coverage of a given magnitude. Using a sample of Chinese listed firms, the results suggest that in relation to CSR, negative media coverage has an inverted U‐shaped curve. When we explore two industrial‐level boundary conditions, we find that this nonlinear relationship is more pronounced in firms with higher industrial concentration and dynamism. The results are robust after controlling for endogeneity. This study contributes to CSR and communication literature by deepening our understanding of the nonlinear impact of negative media coverage on firms.
Exercising autonomy—The effectiveness and meaningfulness of autonomy support interventions engaged by adults with intellectual disability. A mixed‐methods review
Authors: Carey Eileen , Ryan Ruth , Sheikhi Ali , Dore Liz 
Published: March 2022

AbstractBackgroundThe United Nations Convention on the Rights of Persons with Disabilities (UNCRPD) recommend all disabled people receive support to develop their autonomy. Subsequently, evolving models for supported decision‐making and informed consent present guidance to enable autonomy support, which have relevance to people with intellectual disabilities. To date, reviews have explored how adults with intellectual disabilities exercise their autonomy or factors impacting the development of their self‐determination. This review aimed to establish the effectiveness of ‘autonomy support interventions’ engaged by adults with intellectual disability and the meaning of these interventions to this cohort.MethodsA systematic search of Cinahl Complete, PsychINFO and Scopus databases was undertaken. The search was limited to studies published between 2000 and 2020. Identified citations were uploaded to EndNote X9, duplicates removed, search outputs imported into Covidence and titles and abstracts screened. Data were extracted using an amended JBI data extraction Tool. The search strategy is reported in the adapted PRISMA flow diagram.FindingsTwelve studies were included in the mixed methods review. Critical appraisal was undertaken using the Crowe Critical Appraisal Tool. These findings identified varied and creative autonomy support interventions utilised across ordinary activities with adults with intellectual disabilities.ConclusionThis review identifies the essential components of how autonomy support interventions can enhance ordinary experiences for adults with intellectual disabilities while enabling them to develop skill sets to be more self‐directed in the choices they make.
Transition model for coronavirus management
Authors: Djogbenou Antoine , Gourieroux Christian , Jasiak Joann , Rilstone Paul , Bandehali Maygol 
Published: March 2022

AbstractThis paper examines the individual records of patients treated for COVID‐19 during the early phase of the pandemic in Ontario. We trace out daily transitions of patients through medical care of different intensity and address the right truncation in the database. We also examine the sojourn times and reveal duration dependence in the treatments for COVID‐19. The transition model is used to estimate and forecast the counts of patients treated for COVID‐19 in Ontario, while adjusting for the right truncation and right censoring in the sample. This research is based on the Public Health Ontario (PHO) data set from May 7, 2020.
Friedlӓnder's synthesis of quinolines as a pivotal step in the development of bioactive heterocyclic derivatives in the current era of medicinal chemistry
Authors: Rajendran Satheeshkumar , Sivalingam Kalaiselvi , Karnam Jayarampillai Rajendra Prasad , Wang Wen‐Long , Salas Cristian. O 
Published: March 2022

AbstractIn the current scenario of medicinal chemistry, quinoline plays a pivotal role in the design of new heterocyclic compounds with several pharmacological properties, so the search for new synthetic methodologies and their application in drug discovery has been widely studied. So far, many procedures have been performed for the preparation of quinoline scaffolds, among which Friedländer quinoline synthesis plays an important role in obtaining these heterocycles. The Friedländer reaction involves condensation between 2‐aminobenzaldehydes and keto‐compounds. The quinoline nucleus, once obtained through the Friedländer synthesis, has been extensively modified so that these derivatives can exhibit a large number of biological activities such as anticancer, antimalarial, antimicrobial, antifungal, antituberculosis, and antileishmanial properties. In this work, the focus is on the applicability of the Friedländer reaction in the synthesis of various types of bioactive heterocyclic quinoline compounds, which to date has not been reported in the context of medicinal chemistry. The main part of this review selectively focuses on research from 2010 to date and will present highlights of the Friedländer quinoline synthesis procedures and findings to address biological and pharmacological activities.
Connective tissue graft vs porcine collagen matrix after immediate implant placement in esthetic area: A randomized clinical trial
Authors: Puisys Algirdas , Deikuviene Justina , Vindasiute‐Narbute Egle , Razukevicus Dainius , Zvirblis Tadas , Linkevicius Tomas 
Published: March 2022

AbstractBackgroundThe use of connective tissue graft (CTG) with immediate implant placement and provisionalisation have shown promising results. It is not clear if the same outcome could be achieved using porcine‐derived collagen matrix (PDCM) as grafting material.ObjectivesThis study aimed to assess the esthetic and functional outcomes of immediate temporization of immediately placed fully tapered implants combined with bone and soft tissue augmentation, using either a CTG or a PDCM, in fresh extraction sockets of the anterior sites.Materials and MethodsPatients with a failing anterior tooth were included in this study. After extraction, they received an immediate implant with simultaneous hard and soft tissue augmentation and immediate provisional restoration. Patients were randomly assigned to one of the group. Soft tissue augmentation in the control group (CTG) consisted of a CTG, whereas PDCM was used in the test group. After 4 months, definitive restorations were delivered, and pink esthetic score (PES) was evaluated at T1, prosthetic delivery, and at 12‐month follow‐up (T2). In addition, crestal bone change, probing depth, bleeding on probing, plaque index, bleeding on provisional removal, and implant stability quotient were also recorded.ResultsA total of 45 patients received the intended treatment (22 controls and 23 tests) 45 implants totally, with no implant failures at T2. PES mean ± SD after 1 year was noted to be 12.9 ± 1.2 for the CTG group and 12.1 ± 1.3 for the PDCM group (p = 0.507).ConclusionWithin the limits of this trial, both treatment protocols resulted in comparable esthetic outcomes, with results showing PES >12 and stable clinical parameters after 1 year of follow‐up.
Artificial biofilm removal in a peri‐implant mucositis model: Efficacy of air polishing technology as adjunct to ultrasonic debridement alone and impact of the site and the depth of mucosal tunnel—An in vitro study
Authors: Discepoli Nicola , Mirra Raffaele , Vesentin Cecilia , Marruganti Crystal , Ferrari Marco 
Published: March 2022

AbstractAimThe current in vitro model aims to evaluate the adjunctive effect on artificial biofilm removal determined by the use of a glycine‐powder air‐polishing procedure (GPAP) over the ultrasonic debridement (USD) alone when the removal of artificial biofilm on abutment surface is performed. The procedures were carried out also evaluating the impact of the site (mesial, distal, vestibular, and oral) and three different mucosal tunnel depths (2 mm, 4 mm, and 6 mm).Materials and MethodsSingle tooth implant replacement was simulated. Three different abutment heights together with a prosthetic contour were investigated (2 mm, 4 mm, and 6 mm); custom‐made gingival masks were created to mimic peri‐implant soft tissue. Biofilm was simulated with an indelible ink. The protocol consisted in two intervention stages for each abutment: (a) USD with PEEK tip plus (b) GPAP. At the end of each intervention, abutments were unscrewed, and standardized photographs were taken. Statistical analysis was carried out to compare residual stain percentage between the two intervention stages and among different sites and mucosal tunnels.ResultsA total of 30 abutments were instrumented. A significant reduction of the percentage of residual staining (PRS) after the combination of GPAP + USD over USD alone was demonstrated (16% vs. 32%; p < 0.05). Moreover, the better performance of the GPAP + USD protocol was observed regardless of the different mucosal tunnel heights and the sites analyzed. Intragroup analysis unveils that the smaller PRS was observed for shallow mucosal tunnels (2 mm) and vestibular sites for both protocols.ConclusionGPAP + USD provided adjunctive effect on artificial biofilm removal in comparison to the USD alone. Furthermore, proximal surfaces and deeper mucosal tunnels (4 and 6 mm) showed a reduced instrumentation efficacy for both protocols.