bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC
Authors: Li Kun , Gong Yihang , Qiu Dongbo , Tang Hui , Zhang Jian , Yuan Zenan , Huang Yingqi , Qin Yunfei , Ye Linsen , Yang Yang 
Published: August 2022

BackgroundEmerging evidence indicates that the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) axis plays a pivotal role in intrinsic antitumor immunity. Previous studies demonstrate that the conventional chemotherapy agent, teniposide, effectively promotes the therapeutic efficacy of programmed cell death protein-1 antibody (PD-1 Ab) through robust cGAS-STING activation. Unfortunately, the cGAS expression of tumor cells is reported to be severely suppressed by the hypoxic status in solid tumor. Clinically, enhancing chemotherapy-induced, DNA-activated tumor STING signaling by alleviating tumor hypoxia might be one possible direction for improving the currently poor response rates of patients with hepatocellular carcinoma (HCC) to PD-1 Ab.MethodsTeniposide was first screened out from several chemotherapy drugs according to their potency in inducing cGAS-STING signaling in human HCC cells. Teniposide-treated HCC cells were then cultured under hypoxia, normoxia or reoxygenation condition to detect change in cGAS-STING signaling. Next, oxaliplatin/teniposide chemotherapy alone or combined with hyperbaric oxygen (HBO) therapy was administered on liver orthotopic mouse tumor models, after which the tumor microenvironment (TME) was surveyed. Lastly, teniposide alone or combined with HBO was performed on multiple mouse tumor models and the subsequent anti-PD-1 therapeutic responses were observed.ResultsCompared with the first-line oxaliplatin chemotherapy, teniposide chemotherapy induced stronger cGAS-STING signaling in human HCC cells. Teniposide-induced cGAS-STING activation was significantly inhibited by hypoxia inducible factor 1α in an oxygen-deficient environment in vitro and the inhibition was rapidly removed via effective reoxygenation. HBO remarkably enhanced the cGAS-STING-dependent tumor type Ⅰ interferon and nuclear factor kappa-B signaling induced by teniposide in vivo, both of which contributed to the activation of dendritic cells and subsequent cytotoxic T cells. Combined HBO with teniposide chemotherapy improved the therapeutic effect of PD-1 Ab in multiple tumor models.ConclusionsBy combination of two therapies approved by the Food and Drug Administration, we safely stimulated an immunogenic, T cell-inflamed HCC TME, leading to further sensitization of tumors to anti-PD-1 immunotherapy. These findings might enrich therapeutic strategies for advanced HCC andwe can attempt to improve the response rates of patients with HCC to PD-1 Ab by enhancing DNA-activated STING signaling through effective tumor reoxygenation.
Snail-regulated exosomal microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance
Authors: Cheng Han-Ying , Hsieh Chia-Hsin , Lin Po-Han , Chen Yu-Tung , Hsu Dennis Shin-Shian , Tai Shyh-Kuan , Chu Pen-Yuan , Yang Muh-Hwa 
Published: August 2022

BackgroundCompared with the precise targeting of drug-resistant mutant cancer cells, strategies for eliminating non-genetic adaptation-mediated resistance are limited. The pros and cons of the existence of inflammasomes in cancer have been reported. Nevertheless, the dynamic response of inflammasomes to therapies should be addressed.MethodsTumor-derived exosomes were purified by differential ultracentrifugation and validated by nanoparticle tracking analysis and transmission electron microscopy. A proximity ligation assay and interleukin-1β (IL-1β) level were used for detecting activation of NLRP3 inflammasomes. RNA sequencing was used to analyze the exosomal RNAs.MIR21knocked out human monocytic THP cells andmir21knocked out murine oral cancer MTCQ1 cells were generated for confirming the exosomal delivery of microRNA (miR)-21. Syngeneic murine models for head and neck cancer (C57BLJ/6J), breast cancer (BALB/C) and lung cancer (C57BL/6J) were applied for examining the impact of Snail-miR21 axis on inflammasome activation in vivo. Single-cell RNA sequencing was used for analyzing the tumor-infiltrated immune cells. Head and neck patient samples were used for validating the findings in clinical samples.ResultsWe demonstrated that in cancer cells undergoing Snail-induced epithelial-mesenchymal transition (EMT), tumor cells suppress NLRP3 inflammasome activities of tumor-associated macrophages (TAMs) in response to chemotherapy through the delivery of exosomal miR-21. Mechanistically, miR-21 repressesPTENandBRCC3to facilitate NLRP3 phosphorylation and lysine-63 ubiquitination, inhibiting NLRP3 inflammasome assembly. Furthermore, the Snail-miR-21 axis shapes the post-chemotherapy tumor microenvironment (TME) by repopulating TAMs and by activating CD8+T cells. In patients with head and neck cancer, the Snail-high cases lacked post-chemotherapy IL-1β surge and were correlated with a worse response.ConclusionsThis finding reveals the mechanism of EMT-mediated resistance beyond cancer stemness through modulation of post-treatment inflammasome activity. It also highlights the dynamic remodeling of the TME throughout metastatic evolution.
Cosmic acceleration and geodesic deviation in chameleon scalar field model
Authors: Zaregonbadi Raziyeh , Saba Nasim , Farhoudi Mehrdad 
Published: August 2022

AbstractWhile considering the chameleon scalar field model with the spatially flat FLRW background, we investigate the late-time acceleration phase of the universe, wherein we apply the typical potential usually used in this model. Through setting some constraints on the free parameters of the model, we indicate that the non-minimal coupling between the matter and the scalar field in such a model should be strongly coupled in order to have an accelerated expansion of the universe at the late-time. We also investigate the relative acceleration of the parallel geodesics by obtaining the geodesic deviation equation in the context of chameleon model. Then, through the null deviation vector fields, we obtain the observer area-distance as a measurable quantity to compare the model with other relevant models.
Hadron pair production in semi-inclusive electron positron annihilation process at twist-4
Authors: Yang Weihua 
Published: August 2022

AbstractFragmentation functions are important quantities in describing the hadronization process in high energy reactions. They can induce various azimuthal modulations which can be measured to reveal correlations between transverse momenta and polarizations. Without introducing initial state uncertainties, electron positron annihilation process is known as an ideal process to investigate the fragmentation functions. In this paper, therefore, we calculate the hadron pair production in the semi-inclusive electron positron annihilation process $$e^+ + e^- \rightarrow h_1+h_2 + {\bar{q}} +X$$

e
+

+

e
-

→

h
1

+

h
2

+

q

¯

+
X

at twist-4 to study dihadron fragmentation functions. Here $${\bar{q}}$$

q

¯

denotes an antiquark that corresponds to a jet of hadrons in experiments. Together with single hadron fragmentation functions, dihadron fragmentation functions can provide additional ways to extract nucleon parton distribution functions from the semi-inclusive deeply inelastic scattering experiments with two detected final state hadrons. We calculate the differential cross section of the hadron pair production semi-inclusive electron positron annihilation process at twist-4 level. The calculation is carried out by using the collinear expansion method. We also calculate azimuthal asymmetries in terms of dihadron fragmentation functions. Contributions from four-quark correlator are also taken into account. Both the electromagnetic and weak interactions are considered in this paper.
Control of quantum dynamics: non-Markovianity and speedup of a massive particle evolution due to gravity
Authors: Wang Qi , Xu Kai , Yan Wei-Bin , Zhang Ying-Jie , Man Zhong-Xiao , Xia Yun-Jie , Fan Heng 
Published: August 2022

AbstractWe illustrate two linear configurations (one-side model and two-side model) for implementing a non-Markovian speedup evolution of a massive particle gravitationally coupled with a controllable environment: multiple massive particles. By controlling the environment, for instance by choosing a judicious the mass of the environmental particles or by changing the separation distance of each massive particle, two dynamical crossover behaviors from Markovian to non-Markovian and from no-speedup to speedup are achieved due to the gravitational interactions between the system particle and each environmental particle. Numerical calculation also shows that the critical mass of the environmental particles or the critical separation distance for these two dynamical crossover behaviors restrict each other directly. The larger the value of the mass of the environmental particles is, the smaller the value of the critical separation distance should be requested. In this work, the non-Markovian dynamics is the principal physical reason for the speedup evolution of a quantum system. Particularly, the non-Markovianity of the system mass particle in the two-side model has better correspondence with the quantum speed limit time than that in the one-side model.
Formation of primordial black holes after Starobinsky inflation
Authors: Frolovsky Daniel , Ketov Sergei V. , Saburov Sultan 
Published: August 2022

In this paper, we adapted the Appleby–Battye–Starobinsky model of [Formula: see text] gravity towards describing double cosmological inflation and formation of primordial black holes with masses up to [Formula: see text] g in the single-field model. We found that it is possible to get an enhancement of the power spectrum of scalar curvature perturbations to the level beyond the Hawking (black hole evaporation) limit of [Formula: see text] g, so that the primordial black holes resulting from gravitational collapse of those large primordial perturbations can survive in the present universe and form part of cold dark matter. Our results agree with the current measurements of cosmic microwave background radiation within [Formula: see text] but require fine-tuning of the parameters.
MANAGEMENT AND TECHNOLOGICAL INNOVATIONS: IS THERE A VIRTUOUS CIRCLE?
Authors: ATTIA MERIAM , YOUSFI OUIDAD 
Published: August 2022

Purpose: The main aim of this paper is to analyse the association between management and technological innovations. Specifically, we determine whether organisational innovations influence technological ones or vice versa. Design/approach: This study is drawn from a sample of listed firms on the SBF120 1 index and French Community Innovation Surveys (CIS) carried out between 2004 and 2016. Findings: Our study provides the following: First, we show that the introduction of new technological innovations could stimulate organisational changes in a firm’s structure. Second, the adoption of new management practices is likely to increase the introduction of new processes, however, it is not sufficient to favour the development of new or significantly improved products. Research limitations/implications: We studied different types of innovations, but we have ignored other forms of non-technological innovation, such as marketing innovations. It would be interesting to analyse the interaction between marketing and technological innovations. Practical implications: From a business perspective, we emphasise that firms should introduce new organisational methods in the firm’s business practices, workplace organisation, or external relations, and adopt managerial transformations to boost their innovation potential. Originality/value: To the best of our knowledge, this is the first paper that looks at the dynamic character between organisational and technological innovations, especially through a longitudinal study. 1 The SBF120 index consists of the largest 120 capitalizations listed on the French stock Exchange market (SBF: Société des Bourses Françaises).
Estimating the Susceptibility of Four Wheat Cultivars to the Saw-Toothed Grain Beetle Oryzaephilus surinamensis (L.) (Coleoptera: Silvanidae)
Authors: Gharsan Fatehia Nasser 
Published: August 2022

The quality and quantity of wheat are severely affected by insect infestation during storage. Excessive use of chemical pesticides has resulted in several environmental issues, in addition to the emergence of pesticide-resistant strains. Extensive research has been conducted to determine sustainable alternatives, such as the selection and cultivation of insect-resistant crop varieties. The aim of this study was to determine the degree of susceptibility of four wheat cultivars, namely, Albelad, Aldwasair, Australia, and Najran (NJ), to Oryzaephilus surinamensis (L.) using four parameters: F1 progeny, length of developmental period, Dobie’s index of susceptibility (DI), and percentage weight loss (PWL). Albelad was highly susceptible (DI =17.44) to O. surinamensis, followed by Najran (DI =8.42) and Australia (DI =6.18) (susceptible and moderately susceptible, respectively), whereas Aldwasair was moderately resistant (DI =4.67). Furthermore, there were significant positive correlations between DI and the mean number of F1 progeny (

R

2

= 0.98) and between DI and grain weight loss (

R

2

= 0.95). However, a significantly negative correlation (

R

2

= −0.86) was observed between DI and beetle developmental period. These findings will aid the development of breeding programs to maintain the quality and quantity of wheat grains during storage.
Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation and Valve Replacement or Repair
Authors: Mentias Amgad , Saad Marwan , Michael Madonna , Nakhla Shady , Menon Venu , Harb Serge , Chaudhury Pulkit , Johnston Douglas , Saliba Walid , Wazni Oussama , Svensson Lars , Desai Milind Y. , Kapadia Samir 
Published: August 2022

Background
We sought to examine outcomes of direct oral anticoagulants (DOACs) versus warfarin in atrial fibrillation with valve repair/replacement.

Methods and Results

Two atrial fibrillation cohorts from Medicare were identified from 2015 to 2019. They comprised patients who underwent surgical or transcatheter mitral valve repair (MV repair cohort) and surgical aortic or mitral bioprosthetic or transcatheter aortic valve replacement (bioprosthetic cohort). Each cohort was divided into warfarin and DOACs (apixaban, rivaroxaban, and dabigatran) groups. Study outcomes included mortality, stroke, and major bleeding. Inverse probability weighting was used for adjustment between the 2 groups in each cohort. The MV repair cohort included 1178 patients. After a median of 468 days, DOACs were associated with lower risk of mortality (hazard ratio [HR], 0.67 [95% CI, 0.55–0.82],
P
<0.001), ischemic stroke (HR, 0.72 [95% CI, 0.52–1.00],
P
=0.05) and bleeding (HR, 0.79 [95% CI, 0.63–0.99],
P
=0.04) compared with warfarin. The bioprosthetic cohort included 8089 patients. After a median follow‐up of 413 days, DOACs were associated with similar risk of mortality (adjusted HR, 0.93 [95% CI, 0.86–1.01],
P
=0.08), higher risk of ischemic stroke (adjusted HR, 1.27 [95% CI, 1.13–1.43],
P
<0.001), and lower risk of bleeding (adjusted HR, 0.86 [95% CI, 0.80–0.93],
P
<0.001) compared with warfarin.

Conclusions
In patients with atrial fibrillation, DOACs are associated with similar mortality, lower bleeding, but higher stroke with bioprosthetic valve replacement and lower risk of all 3 outcomes with MV repair compared with warfarin.
How Did Taiwan Go from ‘Most Affected’ during sars to ‘Least Affected’ during covid-19?
Authors: Loduhova Alzbeta , Kironska Kristina 
Published: August 2022

Abstract
Taiwan was one of the places most affected by sars in 2003—but one of the least affected by covid-19 in the first year of the pandemic. Taiwan deployed a centralised approach and has been able to effectively eliminate the threat of the spread of covid-19 through swift decisions and effective action. This paper compares and evaluates the Taiwanese government’s emergency responses to two health crises: sars in 2003 and covid-19 in 2020. The policy responses to both are mapped out on easily comprehensible timelines. The study also explores how one crisis governance influences another—how the mishandling of the sars outbreak influenced early governmental responses to covid-19. These are described in more detail, divided into thematic sections, and accompanied by illustrative images.
Exploring Mechanisms Underlying Unexplained Air-Bone Gaps Post-Myringoplasty: Temporal Bone Model and Finite Element Analysis
Authors: Wang Jie , Wei Xingmei , Zhang Ying , Koike Takuji , Lee Sinyoung , Li Yongxin , Zhao Fei 
Published: August 2022

Purpose Air-bone gap (ABG) is an essential indicator of middle ear transfer function after myringoplasty. However, there is still uncertainty about the mechanisms behind unexplained ABGs in patients post-myringoplasty. The present study investigated these mechanisms using cadaveric temporal bone (TB) measurement and finite element (FE) modeling. Methods Three conditions of tympanic membrane (TM) perforation were modeled with a perforated area of 6%, 24%, and 50% of the total TM area to simulate a small, medium, or large TM perforation of TB model. A piece of paper was used to patch the TM perforation to simulate the situation post-myringoplasty. In the FE model for post-operation, the material properties at the perforation area were changed. Measurement of TM vibration at the umbo was undertaken with a laser Doppler vibrometer (LDV). Results As the perforated area increased vibration of the TM at the umbo decreased in both the TB and FE models. But the reduction of TM vibration is more minor in the FE model than in the TB model. After the perforation was repaired, the displacement of TM at the umbo could not be recovered totally in the TB and FE models. In the FE model, the displacement of TM at the umbo decreased markedly when the cone shape of TM flattened, and the reduction was almost the same as that in the TB model in the condition of large perforation. Conclusion The material properties and the anatomical shape of the repaired TM could influence the TM’s modal motion and wave motion. Except for appearance and shape current clinical instruments are unable to resolve factors that affect TM motion. Consequently the ABG seen post-myringoplasty remains unexplained.
O-carboxymethyl chitosan/gelatin/silver-copper hydroxyapatite composite films with enhanced antibacterial and wound healing properties
Authors: Valencia-Gómez Laura-E , Muzquiz-Ramos Elia-M , Fausto-Reyes Abril-D , Rodríguez-Arrellano Priscila-I , Rodríguez-González Claudia-A , Hernández-Paz Juan-F , Reyes-Blas Hortensia , Olivas-Armendáriz Imelda 
Published: August 2022

Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin were prepared and mixed with hydroxyapatite (HA) composited with Silver (Ag) and Copper (Cu) at different concentrations. The chemical, thermal, morphological, and biological properties of the composite films were studied. The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex. The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9–12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h. The films obtained can serve as a wound healing dressing and regenerating biomaterial.
Premature ovarian failure in juvenile systemic lupus erythematosus patient: A rare presentation
Authors: Tekgöz Nilüfer , Taş Demet , Çelikel Elif , Özlü Sare Gülfem , Acar Banu 
Published: August 2022

A 16-year-old girl was admitted to the hospital for the absence of a menstrual bleeding over 10 mounts. She has had regular menstrual periods since she was 13 years old and no history of systemic disease. Laboratory tests showed low estrogen (<11.8 ng/L, range 16–238 ng/L), elevated FSH (follicle stimulating hormone) (138.3 U/L), low AMH (anti-Mullerian hormone) (<0.01 µg/L), normal prolactin (7 μg/L), and thyroid hormone levels (TSH: 1.5 mU/L). The ovaries were prepubertal in size and diagnosed with primer ovarian failure. ANA titers, antiphospholipid antibody, and direct coombs were positive. Microscopic hematuria and nephritic proteinuria (34 mg/m2/hour) were also detected and renal biopsy was revealed stage 3–5 lupus nephritis. Premature ovarian failure is an extremely rare disease in childhood. When POF is detected in the adolescent, it is important to investigate the etiology. In this way, it may be possible to diagnose diseases with high morbidity and mortality that may cause POF.
EEG-ERP Correlates of Cognitive Dysfunction in Polycystic Ovarian Syndrome
Authors: Showkath Neethu , Sinha Meenakshi , Ghate Jayshri R. , Agrawal Sarita , Mandal Sucharita , Sinha Ramanjan 
Published: August 2022

Background Polycystic ovarian syndrome (PCOS) has been shown to affect the psychological and cognitive status of a woman. However, amidst various conflicting reports in this regard, very few studies attempted to assess these aspects objectively using electroencephalography (EEG) and event-related potential (ERP). Purpose To assess changes in neurocognitive and psychological parameters of PCOS women without any other comorbidities. Methods PCOS women aged 18 years to 35 years, diagnosed from obstetrics and gynecology OPD who are otherwise free of any other comorbidities, were assessed for psychological status (anxiety and depression using the State-Trait Anxiety Inventory and Beck Depression Inventory, respectively). Thereafter, a cognitive assessment was done subjectively by the Montreal Cognitive Assessment (MoCA) questionnaire and objectively by using EEG [absolute and relative power of alpha, beta, and theta waves along with theta/beta ratios (TBR) and theta/alpha ratio (TAR)] and P300 amplitude and latency of ERP during a visual oddball paradigm task in control ( n = 30) and PCOS ( n = 37) subjects. Results PCOS women showed significantly higher anxiety and depression scores along with low MoCA scores. Significantly reduced absolute alpha, increased frontal beta, and markedly increased theta (relative) power with increased TAR in the PCOS group were seen. Also, a significant reduction in P300 amplitude with prolonged latency during the visual oddball paradigm task was evident in them. Conclusion Reduced alpha and higher theta activity with increased TAR are indicative of poor neural processing ability. Reduced P300 amplitude with more latency also suggests a cognitive decline, which is corroborated by reduced MoCA scores. Our study objectively indicates the presence of subclinical cognitive impairment in PCOS patients even without any comorbidities.