bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-life outcomes in biotypes of psychotic disorders based on neurocognitive performance
Authors: Molina Vicente , Fernández-Linsenbarth Inés , Queipo-de-Llano María , Jiménez-Aparicio María Teresa , Vallecillo-Adame Carmen , Aremy-Gonzaga Abril , de-Andrés-Lobo Celia , Recio-Barbero María , Díez Álvaro , Beño-Ruiz-de-la-Sierra Rosa M. , Martín-Gómez Carmen , Sanz-Fuentenebro Javier 
Published: November 2022

AbstractAiming at discerning potential biotypes within the psychotic syndrome, we have recently reported the possible existence of two clusters or biotypes across schizophrenia and bipolar disorder characterized by their cognitive performance using the Brief Assessment of Cognition in Schizophrenia (BACS) instrument and validated with independent biological and clinical indexes (Fernández-Linsenbarth et al. in Schizophr Res 229:102–111, 2021). In this previous work, the group with larger cognitive deficits (N = 93, including 69 chronic schizophrenia, 17 first episodes (FE) of schizophrenia and 7 bipolar disorder patients) showed smaller thalamus and hippocampus volume and hyper-synchronic electroencephalogram than the group with milder deficits (N = 105, including 58 chronic schizophrenia, 25 FE and 22 bipolar disorder patients). We predicted that if these biotypes indeed corresponded to different cognitive and biological substrates, their adaptation to real life would be different. To this end, in the present work we have followed up the patients’ population included in that work at 1st and 3rd years after the date of inclusion in the 2021 study and we report on the statistical comparisons of each clinical and real-life outcomes between them. The first cluster, with larger cognitive deficits and more severe biological alterations, showed during that period a decreased capacity for job tenure (1st and 3rd years), more admissions to a psychiatric ward (1st year) and a higher likelihood for quitting psychiatric follow-up (3rd year). Patients in the second cluster, with moderate cognitive deficits, were less compliant with prescribed treatment at the 3rd year. The differences in real-life outcomes may give additional external validity to that yielded by biological measurements to the described biotypes based on neurocognition.
Nano- and micro-structures in lunar zircon from Apollo 15 and 16 impactites: implications for age interpretations
Authors: Kusiak Monika A. , Kovaleva Elizaveta , Vanderliek Dennis , Becker Harry , Wilke Franziska , Schreiber Anja , Wirth Richard 
Published: November 2022

AbstractMeteorite impact processes are ubiquitous on the surfaces of rocky and icy bodies in the Solar System, including the Moon. One of the most common accessory minerals, zircon, when shocked, produces specific micro-structures that may become indicative of the age and shock conditions of these impact processes. To better understand the shock mechanisms in zircon from Apollo 15 and 16 impact breccias, we applied transmission electron microscopy (TEM) and studied nano-structures in eight lunar zircons displaying four different morphologies from breccias 15455, 67915, and 67955. Our observations revealed a range of shock-related features in zircon: (1) planar and non-planar fractures, (2) “columnar” zircon rims around baddeleyite cores, (3) granular textured zircon, in most cases with sub-µm-size inclusions of monoclinic ZrO2(baddeleyite) and cubic ZrO2(zirconia), (4) silica-rich glass and metal inclusions of FeS and FeNi present at triple junctions in granular zircon and in baddeleyite, (5) inclusions of rutile in shocked baddeleyite, (6) amorphous domains, (7) recrystallized domains. In many grain aggregates, shock-related micro-structures overprint each other, indicating either different stages of a single impact process or multiple impact events. During shock, some zircons were transformed to diaplectic glass (6), and others (7) were completely decomposed into SiO2and Zr-oxide, evident from the observed round shapes of cubic zirconia and silica-rich glass filling triple junctions of zircon granules. Despite the highly variable effect on textures and Zr phases, shock-related features show no correlation with relatively homogeneous U–Pb or207Pb/206Pb ages of zircons. Either the shock events occurred very soon after the solidification or recrystallization of the different Zr phases, or the shock events were too brief to result in noticeable Pb loss during shock metamorphism.
Micro-analytical and molecular approaches for understanding the distribution, biochemistry, and molecular biology of selenium in (hyperaccumulator) plants
Authors: Pinto Irish Katherine , Harvey Maggie-Anne , Harris Hugh H. , Aarts Mark G. M. , Chan Cheong Xin , Erskine Peter D. , van der Ent Antony 
Published: November 2022

Abstract
Main conclusion
Micro-analytical techniques to untangle Se distribution and chemical speciation in plants coupled with molecular biology analysis enable the deciphering of metabolic pathways responsible for Se tolerance and accumulation.

Abstract
Selenium (Se) is not essential for plants and is toxic at high concentrations. However, Se hyperaccumulator plants have evolved strategies to both tolerate and accumulate > 1000 µg Se g−1 DW in their living above-ground tissues. Given the complexity of the biochemistry of Se, various approaches have been adopted to study Se metabolism in plants. These include X-ray-based techniques for assessing distribution and chemical speciation of Se, and molecular biology techniques to identify genes implicated in Se uptake, transport, and assimilation. This review presents these techniques, synthesises the current state of knowledge on Se metabolism in plants, and highlights future directions for research into Se (hyper)accumulation and tolerance. We conclude that powerful insights may be gained from coupling information on the distribution and chemical speciation of Se to genome-scale studies to identify gene functions and molecular mechanisms that underpin Se tolerance and accumulation in these ecologically and biotechnologically important plants species. The study of Se metabolism is challenging and is a useful testbed for developing novel analytical approaches that are potentially more widely applicable to the study of the regulation of a wide range of metal(loid)s in hyperaccumulator plants.

Graphical Abstract
Development and validation of the Early Pediatric Groningen Defecation and Fecal Continence questionnaire
Authors: Verkuijl Sanne J. , Trzpis Monika , Broens Paul M. A. 
Published: November 2022

AbstractThere are no compatible tools that assess bowel function in young children, older children, and adults. This precludes clinical follow-up and longitudinal scientific research. Our aim was therefore to develop and validate a bowel function questionnaire equivalent to the pediatric (8–17 years) and adult (≥ 18 years) Groningen Defecation and Fecal Continence (DeFeC) questionnaires for children from the age of 1 month to 7 years. We developed, validated, and translated the Early Pediatric Groningen DeFeC (EP-DeFeC) questionnaire according to the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN). The EP-DeFeC incorporates different validated bowel function scoring systems, including the Rome IV criteria that are also included in the pediatric and adult DeFeC. We assessed feasibility and reproducibility by a test–retest survey. The study population (N = 100) consisted of the parents/caregivers of children whose median age was 4.0 (IQR 2.0–5.0) years. The mean interval between testing and retesting was 2.7 ± 1.1 months. None of the respondents commented on ambiguities regarding the questions. The overall median time taken to complete the EP-DeFeC was 8.7 min (IQR 6.8–11.8). The overall observed agreement was 78.9% with an overall kappa coefficient of 0.51, indicating moderate agreement.Conclusion: The EP-DeFeC is a feasible, reproducible, and validated questionnaire for assessing bowel function in children from the age of 1 month to 7 years. If used in combination with its pediatric (8–17 years) and adult (≥ 18 years) equivalents, this questionnaire enables longitudinal follow-up of bowel function from infancy to adulthood.

What is Known:• Bowel function problems are common among young children.• Unfortunately, there are no compatible tools that assess bowel function in young children, older children, and adults, which precludes clinical follow-up and longitudinal scientific research.

What is New:• The Early Pediatric Groningen Defecation and Fecal Continence (EP-DeFeC) questionnaire is validated to assess bowel function in children from the age of 1 month to 7 years.• If used together with its pediatric and adult equivalents, longitudinal follow-up of bowel function from infancy to adulthood becomes possible.
FGFR2-amplified tumor clones are markedly heterogeneously distributed in carcinomas of the upper gastrointestinal tract
Authors: Albin Jan , Fahrig Luca , Siemanowski Janna , Rehkaemper Jan , Gebauer Florian , Zander Thomas , Buettner Reinhard , Bruns Christiane Josephine , Schroeder Wolfgang , Alakus Hakan , Hieggelke Lena , Quaas Alexander 
Published: November 2022

Abstract
Background
FGFR2 is a therapy-relevant target in tumors of the upper gastrointestinal tract (GIT), and clinical trials are currently underway to test the efficacy of FGFR2 inhibitors. Tumor heterogeneity is one of the relevant causes of treatment failure. Almost nothing is known about the heterogeneous distribution of FGFR2-amplified clones in adenocarcinomas of the upper GIT.

Patients and methods
To assess FGFR2 gene copy number alteration and intratumoral heterogeneity of upper GIT adenocarcinomas, we analyzed 893 patient-derived formalin-fixed paraffin-embedded tumor specimens, including primary operated and neoadjuvant-treated tumors (462 gastric carcinomas and 429 esophageal adenocarcinomas) as well as complementary lymph node and distant metastasis by fluorescence in situ hybridization.

Results
Twenty-six gastric tumors (5.6%) and 21 esophageal adenocarcinomas (4.9%) showed FGFR2 amplification. Overall, 93% of gastric carcinomas and 83% of esophageal carcinomas showed heterogeneous amplification. FGFR2 amplification was found in different histological growth patterns, including intestinal and diffuse type according to the Lauren classification. In the primary gastric carcinoma group, FGFR2 amplification was associated with poor prognosis (p = 0.005).

Conclusion
Homogeneous FGFR2 amplification in tumors of the upper GIT is the exception. This has highly relevant implications in the nature of FGFR2 diagnostics (sufficient tumor cell number, determination of amplification at metastasis versus primary tumor, etc.) and on the response probability of appropriate inhibitors. It is relevant that the often poorly treatable and aggressive subtype of diffuse carcinomas (poorly cohesive carcinomas) also shows FGFR2 amplification and that an individualized therapy option with FGFR2 inhibitors could be an option in this group.
Accounting for viscoelastic effects in a multiscale fatigue model for the degradation of the dynamic stiffness of short-fiber reinforced thermoplastics
Authors: Magino Nicola , Köbler Jonathan , Andrä Heiko , Welschinger Fabian , Müller Ralf , Schneider Matti 
Published: November 2022

AbstractUnder fatigue loading, the stiffness decrease in short-fiber reinforced polymers reflects the gradual degradation of the material. Thus, both measuring and modeling this stiffness is critical to investigate and understand the entire fatigue process. Besides evolving damage, viscoelastic effects within the polymer influence the measured dynamic stiffness. In this paper, we study the influence of a linear viscoelastic material model for the matrix on the obtained dynamic stiffness and extend an elastic multiscale fatigue-damage model to viscoelasticity. Our contribution is two-fold. First, we revisit the complex-valued elastic models known in the literature to predict the asymptotic periodic orbit of a viscoelastic material. For small phase shifts in an isotropic linear viscoelastic material, we show through numerical experiments that a real-valued computation of an “elastic” material is sufficient to approximate the dynamic stiffness of a microstructure with a generalized Maxwell material and equal Poisson’s ratios in every element as matrix, reinforced by elastic inclusions. This makes standard solvers applicable to fiber-reinforced thermoplastics. Secondly, we propose a viscoelastic fatigue-damage model for the thermoplastic matrix based on decoupling of the time scales where viscoelastic and fatigue-damage effects manifest. We demonstrate the capability of the multiscale model to predict the dynamic stiffness evolution under fatigue loading of short-fiber reinforced polybutylene terephthalate (PBT) by a validation with experimental results.
The prognostic role of systemic inflammatory markers in apparent early-stage ovarian cancer
Authors: Bizzarri Nicolò , D’Indinosante Marco , Marchetti Claudia , Tudisco Riccardo , Turchiano Francesca , Scambia Giovanni , Fagotti Anna 
Published: November 2022

Abstract
Background
Few studies analyzed the prognostic role of systemic inflammatory markers in early-stage ovarian cancer. The primary endpoint of the present study was to assess the prognostic impact of baseline inflammatory markers in early-stage ovarian cancer. The secondary endpoints were to compare the disease-free survival (DFS) of inflammatory markers with standard risk factors and to correlate these with BRCA mutational status.

Methods
Retrospective, single-center, observational study. Patients with FIGO-stage I–II and IIIA1 epithelial ovarian cancer undergoing primary surgery between 10/2012 and 12/2019 were included. Inflammatory markers were evaluated on the results of the complete blood count and coagulation tests, performed before ovarian cancer surgery. The Receiver Operating Characteristic curve was used to determine the optimal cut-off value of different baseline inflammatory biomarkers for the DFS analysis.

Results
Three hundred fifty-nine patients were included in the study period. Baseline neutrophil–lymphocyte ratio (NLR) ≥ 3 and systemic immune inflammation index (SII, defined as platelet x neutrophil–lymphocyte ratio) ≥ 1000 were associated with worse 3 year DFS and baseline SII ≥ 1000 was associated with worse 3 year OS. BRCA-mutated patients with SII ≥ 1000 and with NLR ≥ 3 had significantly worse DFS compared to SII < 1000 and with NLR < 3. FIGO stage > I was the only independent risk factor for higher risk of recurrence.

Conclusion
SII ≥ 1000 and NLR ≥ 3 were associated with worse 3 year DFS and SII ≥ 1000 was associated with worse 3 year OS. The subgroups of BRCA-mutated patients with higher inflammation markers (SII ≥ 1000 and NLR ≥ 3) were associated with worse DFS. These findings might be helpful to design personalized treatment and more intensive surveillance.
Querying a Clinical Data Warehouse for Combinations of Clinical and Imaging Data
Authors: Kaspar Mathias , Liman Leon , Morbach Caroline , Dietrich Georg , Seidlmayer Lea Katharina , Puppe Frank , Störk Stefan 
Published: November 2022

AbstractThis study aims to show the feasibility and benefit of single queries in a research data warehouse combining data from a hospital’s clinical and imaging systems. We used a comprehensive integration of a production picture archiving and communication system (PACS) with a clinical data warehouse (CDW) for research to create a system that allows data from both domains to be queried jointly with a single query. To achieve this, we mapped the DICOM information model to the extended entity–attribute–value (EAV) data model of a CDW, which allows data linkage and query constraints on multiple levels: the patient, the encounter, a document, and a group level. Accordingly, we have integrated DICOM metadata directly into CDW and linked it to existing clinical data. We included data collected in 2016 and 2017 from the Department of Internal Medicine in this analysis for two query inquiries from researchers targeting research about a disease and in radiology. We obtained quantitative information about the current availability of combinations of clinical and imaging data using a single multilevel query compiled for each query inquiry. We compared these multilevel query results to results that linked data at a single level, resulting in a quantitative representation of results that was up to 112% and 573% higher. An EAV data model can be extended to store data from clinical systems and PACS on multiple levels to enable combined querying with a single query to quickly display actual frequency data.
Assessing community readiness for overweight and obesity prevention among Ghanaian immigrants living in Greater Manchester, England
Authors: Osei-Kwasi Hibbah Araba , Jackson Peter , Akparibo Robert , Holdsworth Michelle , Nicolaou Mary , De Graft Aikins Ama , Griffiths Paula 
Published: November 2022

Abstract
Aim
This study assesses community readiness to prevent overweight/obesity among Ghanaian immigrants in Greater Manchester, England.

Subject and method
The Community Readiness Model (CRM) was applied using a semi-structured interview tool with 13 key informants (religious and other key community members) addressing five readiness dimensions. A maximum of 9 points per dimension (from 1 = no awareness to 9 = high level of community ownership), was assigned, alongside qualitative textual thematic analysis.

Results
The mean readiness score indicated that the study population was in the “vague awareness stage” (3.08 ± 0.98). The highest score was observed for community knowledge of the issue (4.42 ± 0.99) which was in the pre-planning phase, followed by community climate (vague awareness; 3.58 ± 0.62). The lowest scores were seen for resources (denial/resistance; 2.70 ± 0.61) and knowledge of efforts (no awareness; 1.53 ± 0.44). Findings identified structural barriers, including poor living conditions as a result of poorly paid menial jobs and high workload, contributing to the adoption of unhealthy lifestyle behaviours. Socio-cultural factors such as fatalism, hereditary factors, and social status were associated with acceptance of overweight.

Conclusion
Despite recognising overweight/obesity as an important health issue in these communities, especially among women, it is not seen as a priority for targeting change. To help these communities to become more ready for interventions that tackle overweight/obesity, the focus should initially be to address the structural barriers identified, including reducing poverty, alongside designing interventions that work with these structural barriers, and thereafter focus on the socio-cultural factors.
Estimation of the Surface Fluxes for Heat and Momentum in Unstable Conditions with Machine Learning and Similarity Approaches for the LAFE Data Set
Authors: Wulfmeyer Volker , Pineda Juan Manuel Valencia , Otte Sebastian , Karlbauer Matthias , Butz Martin V. , Lee Temple R. , Rajtschan Verena 
Published: November 2022

AbstractMeasurements of three flux towers operated during the land atmosphere feedback experiment (LAFE) are used to investigate relationships between surface fluxes and variables of the land–atmosphere system. We study these relations by means of two machine learning (ML) techniques: multilayer perceptrons (MLP) and extreme gradient boosting (XGB). We compare their flux derivation performance with Monin–Obukhov similarity theory (MOST) and a similarity relationship using the bulk Richardson number (BRN). The ML approaches outperform MOST and BRN. Best agreement with the observations is achieved for the friction velocity. For the sensible heat flux and even more so for the latent heat flux, MOST and BRN deviate from the observations while MLP and XGB yield more accurate predictions. Using MOST and BRN for latent heat flux, the root mean square errors (RMSE) are 107 Wm$$^{-2}$$

-
2

and 121 Wm$$^{-2}$$

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2

, respectively, as well as the intercepts of the regression lines are $$\approx 110$$

≈
110

Wm$$^{-2}$$

-
2

. For the ML methods, the RMSEs reduce to 31 Wm$$^{-2}$$

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2

for MLP and 33 Wm$$^{-2}$$

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2

for XGB as well as the intercepts to just 4 Wm$$^{-2}$$

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2

for MLP and $$-1$$

-
1

Wm$$^{-2}$$

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2

for XGB with slopes of the regression lines close to 1, respectively. These results indicate significant deficiencies of MOST and BRN, particularly for the derivation of the latent heat flux. In fact, in contrast to the established theories, feature importance weighting demonstrates that the ML methods base their improved derivations on net radiation, the incoming and outgoing shortwave radiations, the air temperature gradient, and the available water contents, but not on the water vapor gradient. The results imply that further studies of surface fluxes and other turbulent variables with ML techniques provide great promise for deriving advanced flux parameterizations and their implementation in land–atmosphere system models.
New perspectives in unresectable cholangiocarcinoma? Evaluation of chemosaturation with percutaneous hepatic perfusion as a palliative treatment option
Authors: Dewald Cornelia L. A. , Becker Lena S. , Meine Timo C. , Maschke Sabine K. , Wacker Frank K. , Saborowski Anna , Vogel Arndt , Hinrichs Jan B. 
Published: November 2022

AbstractCholangiocarcinoma (CCA) are the second most common primary liver tumors and carry a dismal prognosis. Chemosaturation with percutaneous hepatic perfusion (PHP) is a palliative, intra-arterial therapeutic approach that provides a high dose chemotherapy of the liver with reduced systemic exposure. Aim of this retrospective, monocentric study was to analyze PHP as a palliative treatment for unresectable CCA. Toxicity, adverse events and complications were classified using the Common Terminology Criteria for Adverse Events (CTCAE v5.0). Overall response rate (ORR) and disease control rate (DCR) were evaluated according to the Response Evaluation Criteria in Solid Tumors (RECIST1.1). Median overall survival (mOS), median progression-free survival (mPFS) and hepatic mPFS (mhPFS) were computed using Kaplan–Meier estimation. In total 17 patients were treated with 42 PHP between 10/2014 and 09/2020. No significant complications occurred during the interventions. mOS was 27.6 (interquartile range (IQR) 16.5–37) months from first diagnosis and 9.9 (IQR 3.8–21) months from first PHP. mPFS was 4 (IQR 2–7) and mhPFS was 4 (IQR 3–10) months. ORR was 25% and DCR 75%. Significant, but transient hematotoxicity was frequent with grade 3/4 thrombopenia after 50%, leukopenia after 26% and anaemia after 21% of the interventions. An increase of transaminases (AST increase after 21% and ALT increase after 14% of the PHP) developed more often than a deterioration of the liver synthesis capacity. Salvage treatment with PHP has the potential to prolong life in selected patients with unresectable, refractory cholangiocarcinoma. The interventional procedure is safe. Post-interventional toxicity is frequent but manageable.