bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Web-Based Prediction Model for Cancer-Specific Survival of Middle-Aged Patients With Non-metastatic Renal Cell Carcinoma: A Population-Based Study
Authors: Tang Jie , Wang Jinkui , Pan Xiudan , Liu Xiaozhu , Zhao Binyi 
Published: February 2022

BackgroundRenal cell carcinoma (RCC) is one of the most common cancers in middle-aged patients. We aimed to establish a new nomogram for predicting cancer-specific survival (CSS) in middle-aged patients with non-metastatic renal cell carcinoma (nmRCC).MethodsThe clinicopathological information of all patients from 2010 to 2018 was downloaded from the SEER database. These patients were randomly assigned to the training set (70%) and validation set (30%). Univariate and multivariate COX regression analyses were used to identify independent risk factors for CSS in middle-aged patients with nmRCC in the training set. Based on these independent risk factors, a new nomogram was constructed to predict 1-, 3-, and 5-year CSS in middle-aged patients with nmRCC. Then, we used the consistency index (C-index), calibration curve, and area under receiver operating curve (AUC) to validate the accuracy and discrimination of the model. Decision curve analysis (DCA) was used to validate the clinical application value of the model.ResultsA total of 27,073 patients were included in the study. These patients were randomly divided into a training set (N = 18,990) and a validation set (N = 8,083). In the training set, univariate and multivariate Cox regression analysis indicated that age, sex, histological tumor grade, T stage, tumor size, and surgical method are independent risk factors for CSS of patients. A new nomogram was constructed to predict patients' 1-, 3-, and 5-year CSS. The C-index of the training set and validation set were 0.818 (95% CI: 0.802-0.834) and 0.802 (95% CI: 0.777-0.827), respectively. The 1 -, 3 -, and 5-year AUC for the training and validation set ranged from 77.7 to 80.0. The calibration curves of the training set and the validation set indicated that the predicted value is highly consistent with the actual observation value, indicating that the model has good accuracy. DCA also suggested that the model has potential clinical application value.ConclusionWe found that independent risk factors for CSS in middle-aged patients with nmRCC were age, sex, histological tumor grade, T stage, tumor size, and surgery. We have constructed a new nomogram to predict the CSS of middle-aged patients with nmRCC. This model has good accuracy and reliability and can assist doctors and patients in clinical decision making.
Specific Features of Patients Under 40 Years Old With Small-to-Medium-Sized Arterial Deterioration
Authors: Matsubara Kazuyoshi , Fukuhara Natsumi , Hoshina Katsuyuki , Miyahara Kazuhiro , Suhara Masamitsu , Taniguchi Ryosuke , Matsukura Mitsuru , Takayama Toshio 
Published: February 2022

BackgroundArterial deterioration is mostly caused by atherosclerosis, which progresses with age. However, we have observed serious backgrounds or etiologies in younger patients with non-atherosclerotic diseases and deterioration of small-to-medium-sized arterial lesions. Therefore, we aimed to identify the specific features of patients aged &lt;40 years with deterioration of small-to-medium-sized arteries.MethodsWe selected patients who were admitted to our department from 1995 to 2019 with deterioration of small-to-medium-sized arteries (aneurysms, dissection, rupture, or arterial injury/damage) and focused on the cohort aged &lt;40 years. We examined the backgrounds or etiologies of the patients including genetic and inflammatory diseases, which might have caused the arterial deterioration.ResultsConsequently, more than half (54.1%) of the patients aged &lt;40 years had non-atherosclerotic comorbid diseases. However, the number of deteriorated arterial lesions was higher in patients aged &lt;40 years than in patients aged ≥40 years (3.13 vs. 1.33 lesion/patient; P = 0.011). Furthermore, the data analysis of patients with multiple arterial lesions (≥3) revealed that the younger population tended to have more specific backgrounds or etiologies, notably Ehlers-Danlos syndrome and Behçet's disease. There were no differences in the all-cause mortality and cardiovascular disease-related mortality between patients aged &lt;40 and ≥40 years (P = 0.89 and 0.29, respectively).ConclusionsOver 50% of patients aged &lt;40 years with deterioration of small-to-medium-sized arteries had non-atherosclerotic, specific clinical backgrounds or etiologies, including genetic and inflammatory diseases. In addition, they exhibited more arterial lesions than older patients.
Prognostic Factors of Short- and Long-Term Outcome in Patients with Advanced Ovarian Cancer
Authors: Доломанова Е.В. , Мириленко Л.В. , Мавричев С.А. 
Published: February 2022

В ходе исследования проведена оценка дооперационных и интраоперационных факторов прогнозирования выживаемости без прогрессирования. Независимую статистически значимую связь с выживаемостью без прогрессирования (ВБП) имеют следующие показатели: характер циторедукции, возраст, объем асцитической жидкости, выполнение диагностической лапароскопии (лапаротомии).Для оценки риска развития тяжелых осложнений у пациенток, страдающих РЯ поздних стадий, разработана номограмма, которая позволяет с высокой точностью (бутстрэп-скорректированный С-индекс – 0,84) оценить индивидуальный риск развития осложнений. Разработанная прогностическая классификация позволяет отнести вновь поступивших пациенток, страдающих РЯ поздних стадий, к классу низкого и высокого рисков развития послеоперационных осложнений.
The present study evaluated preoperative and intraoperative factors for predicting progression- free survival. The following indicators have an independent statistically significant relationship (association) with progression-free survival (PFS): the nature of cytoreduction, age, ascitic fluid volume, and the performance diagnostic laparoscopy (laparotomy).A nomogram has been developed for assessment the risk of developing severe complications in patients with advanced ovarian cancer. The nomogram allows to estimate the individual risk of complications with high accuracy (bootstrap-corrected C-index – 0.84). The developed prognostic classification makes it possible to classify newly admitted patients with advanced ovarian cancer into the class of low and high risks of postoperative complications.
New Opportunities for Prenatal Diagnosis of Fetal Orofacial Clefts in the First Trimester
Authors: Венчикова Н.А. 
Published: February 2022

Орофациальные расщелины относятся к одним из наиболее тяжелых и часто встречающихся аномалий развития лица, входят в состав многих генетических синдромов и хромосом-ных нарушений. Пренатальное выявление пороков орофациальной области осуществляется преимущественно во втором триместре беременности. Нами при обследовании беременных первого триместра, проходивших популяционный пренатальный скрининг в РНПЦ «Мать и дитя», была применена 2D- и 3D-сонография с использованием новых ультразвуковых маркеров для оценки первичного и вторичного нёба плода. Всего за 2018–2019 гг. было обнаружено 9 плодов с расщелиной губы и нёба в сроке 11–13 недель. При всех пренатально выявленных случаях орофациальных расщелин осуществлялось цитогенетическое и/или патоморфологическое исследование.
Orofacial clefts are one of the most severe and common abnormalities in the development of the face, and are а part of many genetic syndromes and chromosomal disorders. Prenatal detection of malformations of the orofacial region is carried out mainly in the second trimester of pregnancy. When examining pregnant women in the first trimester who underwent population prenatal screening at the RSPC “Mother and Child”, we applied 2D- and 3D-sonography using new ultrasound markers to evaluate the primary and secondary palate of the fetus. In total for 2018-2019, 9 fetuses with cleft lip and palate were detected in a period of 11–13 weeks. In all prenatally diagnosed cases of orofacial clefts, cytogenetic and/or pathomorphological studies were performed.
Family Case of Spinal Muscular Atrophy (SMA): Experience of Use of the SMN2 Gene Splicing Modifier (Risdiplam)
Authors: Рушкевич Ю.Н. , Гусина А.А. , Мальгина Е.В. , Лихачев С.А. 
Published: February 2022

В статье приведено описание семейного клинического случая спинальной мышечной атрофии (СМА), подтвержденного молекулярно-генетическим исследованием. Представлена клиническая картина заболевания у взрослых пациентов со СМА, опыт применения рисдиплама. В медикаментозной терапии СМА выделяют два направления: патогенетическая терапия, целью которой является устранение дефицита белка SMN, и симптоматическое лечение, ориентированное на коррекцию отдельных проявлений заболевания. Для патогенетического лечения СМА существует три препарата, применение которых получило одобрение организаций, контролирующих безопасность и эффективность использования лекарственных средств: нусинерсен, золгенсма и рисдиплам. В последнее десятилетие достигнуты значительные успехи в изучении молекулярных механизмов наследственных нервно-мышечных заболеваний. Важным аспектом являются вопросы планирования деторождения, необходимость молекулярно-генетического исследования супругов для оценки риска рождения пораженного потомства.
The article describes a family clinical case of spinal muscular atrophy (SMA), confirmed by molecular genetic research. The clinical picture of the disease in adult patients with SMA, the experience of using Risdiplam are presented. In the drug therapy of SMA, two directions are distinguished: pathogenetic therapy, the purpose of which is to eliminate the deficiency of the SMN protein; and symptomatic treatment focused on the correction of individual manifestations of the disease. There are three drugs for the pathogenetic treatment of SMA, the use of which has received approvalfrom organizations that monitor the safety and effectiveness of drug use: Nusinersen, Zolgensma and Risdiplam. In the latest decade, significant advances have been made in the study of the molecular mechanisms of hereditary neuromuscular diseases. An important aspect is the planning of childbirth, the need for molecular genetic research of spouses to assess the risk of giving birth to affected children.
Young Mentally Ill Patients and Status of Unemployed: Clinical and Psychosocial Indicators
Authors: Семенова Н.Д. , Соколовская Е.В. , Казаковцев Б.А. 
Published: February 2022

В статье поднимается проблема безработицы и отсутствия занятости у лиц молодого возраста с психическими заболеваниями. Подчеркивается важность социального восстановления лиц с психозом, а также роль психосоциальных вмешательств, разработанных для молодых людей с проблемами «социальной инвалидности». Приведены данные кросс-секционного эмпирического исследования, нацеленного на выделение группы повышенного риска среди больных шизофренией в плане ослабления и утраты мотивации к социальному восстановлению. Описана группа безработных пациентов молодого возраста, их клинические и психосоциальные показатели. Обсуждаются вопросы, связанные с предупреждением снижения экономической инактивности лиц молодого возраста с психическими расстройствами.
The article raises the problem of unemployment among young people with mental illness. The importance of social recovery in persons with psychosis and the role of psychosocial interventions, specially designed for young people with psychosis and problems of "social disability", are emphasized. The data of the cross-sectional empirical study aimed at identifying a high-risk group among patients with schizophrenia in terms of weakening and loss of motivation for social recovery are presented. A group of young unemployed patients (clinical and psychosocial indicators) is described. The issues related to prevention and reduction of economic inactivity of young people with mental disorders are discussed.
Postpartum Psychosis: Evolution of Ideas about Etiopathogenesis
Authors: Хвостова И.И. , Докукина Т.В. , Бондарь К.А. 
Published: February 2022

В статье обсуждаются изменения представлений об этиологии и патогенезе послеродовых психозов, произошедшие в последнее десятилетие. Приводятся данные обзора исследований, выполненных при участии женщин, перенесших тяжелые психические расстройства послеродового периода. Изложены результаты генетических исследований, а также исследований, основанных на изучении фармакологической и животной модели постпартального психоза. Обсуждена роль генетической предрасположенности, дисфункции иммунной системы и нарушений процессов миелинизации в возникновении психозов послеродового периода.
In the article, there are discussed the changes in the ideas about the etiology and pathogenesis of postpartum psychoses that have occurred in the latest decade. The review of the studies carried out with participation of women, who have suffered severe mental disorders of the postpartum period, is presented. The results of genetic research are presented, as well as the studies based on the investigation of the pharmacological and animal model of postpartum psychosis. The role of genetic predisposition, immune system dysfunction, and myelination deviations in postpartum psychosis is discussed.
Approaches to Improve Adherence to Treatment and Prognostic Outcomes in Patients with Atrial Fibrillation
Authors: Дешко М.С. , Бойко С.Л. , Ускова И.В. , Гриб С.Н. , Шпак Н.В. , Снежицкий В.А. 
Published: February 2022

Фибрилляция предсердий (ФП) является одной из главных проблем современной кардиологии. Распространенность сердечно-сосудистых заболеваний в популяции, недостаточный контроль факторов риска с одной стороны, увеличение продолжительности жизни и расширение возможностей выявления аритмии с другой привели к значительному росту числа случаев ФП. Течение ФП осложняется развитием инсульта, системных эмболий, сердечной недостаточности, повышается риск внезапной сердечной смерти. Для предупреждения осложнений большинству пациентов требуется постоянный прием пероральной антикоагулянтной (ОАК) терапии, а также лечение сердечно-сосудистых и коморбидных заболеваний. Приверженность к терапии ОАК и контроль факторов риска инсульта и кровотечений являются важными условиями эффективности и безопасности лечения, однако у многих пациентов приверженность остается низкой. Причиной этому служит целый ряд факторов, как связанных с самим пациентом, так и зависящих от врача и системы здравоохранения. Представленный обзор посвящен обсуждению возможных путей повышения приверженности к терапии и их роли для улучшения прогноза у пациентов с ФП с фокусом на их обучение, интегрированную помощь, использование программных средств.
Atrial fibrillation (AF) is one of the major concerns in current cardiology practice. High prevalence of cardiovascular diseases in the population and poor control of the risk factors, as well as the increase of life expectancy and improved arrhythmia detection resulted in continuous increase of the number of AF cases. Stroke and systemic embolism, heart failure, and increased risk of sudden cardiac death are the complications of AF clinical course. For the vast majority of AF patients, the continuous oral anticoagulation (OAC) is required. Management of cardiovascular and comorbid diseases is essential to prevent complications as well. Medication adherence and control of strokeand bleeding risk factors ensure effectiveness and safety of OAC. Nonetheless, adherence remains low in many patients. The latter depends on the patient-related factors. In addition, the impact of physician and health care system is notable. In the current review, we discuss possible approaches to improve adherence and their prognostic impact in patients with AF with the focus on patients’ education, integrated medical care, and use of software tools.
PENGUJIAN PENGGUNAAN BIOCHAR BERBAHAN BAKU SISA POHON KELAPA SAWIT TERHADAP PERTUMBUHAN BIBIT KELAPA SAWIT (Elaeis guineensis Jacq.) DI MAIN NURSERY PADA TANAH ULTISOL ASAL GALANG
Authors: Siboro Jusy 
Published: February 2022

The rest of the oil palm plantations in large quantities, if not processed, can damage the environment. if used properly, it can be used as biochar, which functions to improve the soil. This study aims to determine the effect of testing the use of Biochar made from raw residual Palm Oil Trees for The Growth Of Palm Oil Seeds (Elaeis guenensis Jacq.) in the Main Nursery in Ultisol. The research was conducted using a complete randomized design (RAL) non factorial with 4 replications. The factors is biochar consisting of 5 treatments: B0 (Control); B1 (biochar of stem palm oil); B2 (biochar of palm oil fronds); B3 (biochar of empty fruit bunch compost); B4 (biochar of stem palm oil + fronds + oil empty fruit bunch compost). The parameters observed were plant height, diameter of the stem and number of leaves. The results showed that administration of biochar had no significant effect on increasing plant height, application of biochar also had no significant effect on increasing the diameter the stem, application of biochar had no significant effect on increasing the giving biochar had no number of leaves of oil palm seedlings.
COMPARATIVE STUDY BETWEEN PHYTOGENIC AND ESCHERICHIA COLI VACCINE IN BROILERS
Authors: Abdullah S.M. , Abdulmaged Sahar.H. , Hamad S.M. 
Published: February 2022

The present study carried out to comparative between usage of killed vaccine of Escherichia coli with aromatic oils or alone against infection of broiler with pathogenic E.coli for this purpose two hundred broiler chicks were collected and randomly divided into four groups. Each group contained fifty chicks, food and drink for all groups ad libitium. The experimental groups were treated as follows: G1 vaccinated with the killed E. coli vaccine through subcutaneous injection dose 0.5 ml (3×107 CFU/ml )in day five old and received Digestarom® P.E.P sol. in drinking water 6 ml/100L from one day old until end of trial. G2 vaccinated with killed E. coli only through subcutaneous injection dose 0.5 ml (3×107 CFU/ml) in day five old. G3 received Digestarom® P.E.P sol. in drinking water 6 ml/100Lonly one day old until end of trial. G4 control negative. The experimental birds in day 25 were challenged intratracheally inculated with Escherichia coli of 0.5 ml was LD50(3 ×108 CFU/ml) in the experiment. Blood samples were taken at day 20 and 35 for assessment of different parameters, mortality and lesions score were determined . The results showed that the use of aromatic oils and received killed vaccine of E.coli has a good effect on the immune response , decreasing the mortality rate and lesion score of E. coli infected chickens. It can be concluded from the current study that the use digestarom enhancement the immune response after vaccination with E.coli vaccine against pathogenic E.coliIt also the use E.coli vaccine with the digestarom in broiler chickens is more effective than using the vaccine alone
PEMODELAN BAYESIAN NETWORK UNTUK MENENTUKAN PROBABILITAS PENYEBAB PELANGGARAN DALAM PERTANDINGAN KARATE KUMITE
Authors: Putra Yudha Permadya , Aradea Aradea , Rianto Rianto 
Published: February 2022

Pelanggaran dalam pertandingan karate kumite akan sangat mempengaruhi dalam hasil pertandingan, banyaknya faktor penyebab pelanggaran dalam pertandingan kumite harus diantisipasi se-dini mungkin agar kelak dalam pertandingan berikutnya tidak mengulangi kesalahan yang sama. Itu membuat kompleksitas hubungan faktor ketidakpastian karena bersifat probabilistik. Bayesian Network merupakan Direct Acyclic Graph (DAG) dengan tabel probabilitas untuk setiap node. Node yang terdapat dalam Bayesian Network adalah representasi proporsional variabel dalam domain, dan garis yang menunjukkan ketergantungan hubungan. Berdasarkan deskripsi tersebut, solusi dari kompleksitas ketergantungan faktor ketidakpastian di dalam pertandingan karate kumite dapat dimodelkan menggunakan Bayesian Network untuk mengetahui penyebab pelanggaran yang menjadi variabel acak di dalam sistem pertandingan. Penelitian ini menerapkan teknik pemodelan Bayesian Network berdasarkan data prestasi atlit Bandung Karate Club (BKC) Kota Tasikmalaya tahun 2020. Hasil penelitian ini menunjukan bahwa pemodelan yang telah dibangun untuk menentukan probabilitas penyebab pelanggaran dalam pertandingan karate Kumite mendapatkan nilai Mutual Information sebesar 0,01829 (2,01%) untuk terhentinya suatu pertandingan karena terjadi pelanggaran.
Topology of Augmented Bergman Complexes
Authors: Bullock Elisabeth , Kelley Aidan , Reiner Victor , Ren Kevin , Shemy Gahl , Shen Dawei , Sun Brian , Zhang Zhichun Joy 
Published: February 2022

The augmented Bergman complex of a matroid is a simplicial complex introduced recently in work of Braden, Huh, Matherne, Proudfoot and Wang. It may be viewed as a hybrid of two well-studied pure shellable simplicial complexes associated to matroids: the independent set complex and Bergman complex.
It is shown here that the augmented Bergman complex is also shellable, via two different families of shelling orders. Furthermore, comparing the description of its homotopy type induced from the two shellings re-interprets a known convolution formula counting bases of the matroid. The representation of the automorphism group of the matroid on the homology of the augmented Bergman complex turns out to have a surprisingly simple description. This last fact is generalized to closures beyond those coming from a matroid.
Análise de Clima Organizacional em Equipes de Trabalho na Gestão Pública do Governo de Minas Gerais
Authors: Silva Renato Rodrigues da , Santos Ruan Carlos dos , Lima Alexandre Oliveira , Oliveira Leonel Gois Lima 
Published: February 2022

Objetivo do estudo:A percepção sobre o clima organizacional é uma das variáveis que diferencia as empresas com uma boa gestão de pessoas, daquelas que fazem das pessoas meros recursos necessários para geração de lucro. Tais pesquisas são pouco desenvolvidas no setor público. A pesquisa se justifica pela possibilidade de apontar as variáveis que afetam o clima organizacional, bem como, a satisfação dos servidores públicos pertencentes ao grupo estudado. Originalidade/Relevância:Este estudo está entre os primeiros do setor público a demonstrar a importância do clima organizacional para o desempenho criativo individual dos funcionários. As conclusões deste estudo acrescentam ao nosso conhecimento e compreensão atuais do valor do clima organizacional e sua influência sobre o desempenho criativo individual no setor público. Metodologia: A metodologia é uma pesquisa descritiva, usando para isso a pesquisa bibliográfica e estudo de caso numa abordagem quantitativa. Usou como instrumento um questionário online e a observação direta participante. Principais resultados:Foi identificado o perfil dos servidores bem como as dimensões: Estrutura e ambiente físico; cooperação e reciprocidade no ambiente de trabalho; participação nas decisões; reconhecimento de mérito; identificação com a instituição; controles; autonomia funcional; conflitos; remuneração e oportunidade; perspectiva na instituição que interferem na percepção do clima organizacional pelos servidores obtendo 99 respostas. Os objetivos foram alcançados e notou-se a necessidade de implantar e desenvolver algumas políticas de recursos humanos para sobretudo valorizar o capital intelectual existente dentro de cada órgão. Contribuições teóricas: A pesquisa contribui demonstrar a necessidade das empresas públicas e criarem políticas sobre o clima organizacional entre uma ligação positiva e significativa com as duas variáveis de desempenho criativo incluídas neste estudo. Além disso, o estudo revelou que o indivíduo criativo modifica a relação entre o clima organizacional e o comportamento inovador individual.