bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Accusation of Dohnányi: The Legal Procedure in Hungary, 1945–1946
Authors: Kusz Veronika 
Published: December 2022

AbstractErnő Dohnányi, the world-renowned musician, was almost entirely forgotten during the decades between his emigration in 1944 and the change of political regime in Hungary: his name actually disappeared from public cultural knowledge. Though there may have been several explanations for the ignorance, it is not an exaggeration to state that the main reasons behind the tragic gap in his posthumous reception are of a political nature. It is widely known nowadays that during the settlements after World War II, Dohnányi – in his absence – was charged with intellectual collaboration with the Hungarian far right-wing regime. According to the present state of research, the charges were finally withdrawn as they were mostly ungrounded. Yet, the formerly adored artist and central personality in cultural life had become persona non grata for more than 40 years. After the political changes, his oeuvre seemed to be rehabilitated but without a thorough investigation of the charges and their background. This is why political prejudices are currently experienced simultaneously with a total bagatellization of the possible mistakes in his interwar activity. Thus, a systematic research into this subject has become very urgent. This study, which is intended to be a chapter of a full-length monograph on Dohnányi and politics (expected in 2023/24), was founded by the János Bolyai Scholarship of the Hungarian Academy of Sciences, and is one of the very first publications of this project in English. It aims to give a thorough description of the first two years of the official proceeding against Dohnányi at the different investigative levels such as the justificatory committees, public prosecutor, and government ministry.
Early echocardiographic alterations in cancer patients during chemotherapy
Authors: Fashafsha Z. Z.A. , Chomakhidze P. Sh. , Mesitskaya D. F. , Suvorov A. Yu. , Sekacheva M. I. , Poddubskaya E. V. , Tyukanova E. S. , Sankova M. V. , Ozova M. A. , Levina V. D. , Andreev D. А. , Kopylov F. Yu. 
Published: December 2022

Aim. To evaluate the early manifestation of cardiotoxicity after the first course of multiagent chemotherapy (MAC) using echocardiography with an assessment of the left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS).Material and methods. The study included 49 cancer patients with elective MAC.Results. After the first administration of a therapeutic dose of chemotherapy, a decrease in LVEF ≥10 and GLS >15 was demonstrated in more than 6,1% of patients, as well as a subclinical decrease in LVEF ≥5% in 22,4% and a decrease in GLS ≥12% in 24,5%.Conclusion. In cancer patients, after the first course of chemotherapy, GLS dynamics should be assessed during echocardiography as a marker of myocardial dysfunction.
Risk factors for cardiovascular diseases in patients received complex treatment for cranial and craniospinal tumors in childhood
Authors: Novikova A. I. , Poltavskaya M. G. , Pavlova M. G. , Chomakhidze P. Sh. , Sotnikov V. M. , Potemkina N. A. , Bykova A. A. , Salpagarova Z. K. , Fashafsha Z. Z. , Soboleva T. V. , Andreeva O. V. , Zheludkova O. G. , Andreev D. А. 
Published: December 2022

Aim. To study the traditional risk factors for cardiovascular disease (CVD), indicators of endothelial function and exercise tolerance in patients received complex treatment for cranial and craniospinal tumors in childhood, including radiation therapy.Material and methods. We compared examination data of 48 patients who underwent treatment for brain tumors using cranial and craniospinal irradiation in childhood (mean age, 21,7±4,3 years, mean period after the end of treatment, 6,9±5,4 years), and 20 healthy volunteers. Examination methods included assessment of lipid profile, vascular stiffness and endothelial function using the Photoplethysmography and occlusion test, cardiopulmonary test, and in patients who underwent craniospinal irradiation, also echocardiography and duplex ultrasound of extracranial arteries.Results. Compared to healthy individuals, patients after a brain tumor were found to have lower blood pressure, higher heart rate (HR), significantly lower exercise performance (peak oxygen consumption, 19,8±6,4 ml×min-1×kg vs 30,3±5,8 ml×min-1×kg, p<0,0001) and a higher prevalence of dyslipidemia (56% vs 5%, p<0,0001), as well as an increase in the augmentation index, indicating higher stiffness of large vessels (-7,3±16,3 vs -20,3±7,9, p=0,001), and a trend towards a decrease in the occlusion index (p=0,051). Echocardiography and duplex ultrasound revealed no radiation-associated abnormalities.Conclusion. Determining the mechanisms and prognostic significance of the identified risk factors for CVD (dyslipidemia, decreased exercise tolerance, increased heart rate and vascular stiffness) in this category of patients requires further research. Regular monitoring of risk factors, primarily the lipid profile, and the use of preventive measures for individuals with an increased risk of CVD should be recommended.
High-sensitivity troponin I as a predictor of left ventricular dysfunction in the use of cardiotoxic anticancer agents for breast cancer in patients with predominantly low and moderate risk of cardiotoxicity
Authors: Levina V. D. , Poltavskaya M. G. , Chomakhidze P. Sh. , Meshcheryakov A. A. , Bolotina L. V. , Deshkina T. I. , Valiulina D. S. , Gerasimov A. N. , Andreeva O. V. , Shmeleva A. A. , Fashafsha Z.Z.A. , Levshina A. R. , Sedov V. P. 
Published: December 2022

Aim. To study the significance of monitoring high-sensitivity troponin I (hs-cTnI) for predicting anthracycline-induced left ventricular (LV) dysfunction in the treatment of breast cancer in patients with moderate and low risk of cardiotoxicity (CT).Material and methods. The study involved 49 patients with breast cancer aged 50±10 years who underwent neoadjuvant or adjuvant chemotherapy, which included doxorubicin at a course dose of 60 mg/m2 and an average cumulative dose of 251±60 mg/m2. The level of hs-cTnI was determined by an ultrasensitive method before the start of chemotherapy, after each course of anthracyclines and in 18 patients before the administration of anthracyclines. The level of hscTnI >0,017 ng/ml was considered elevated. Echocardiography was performed before the start of chemotherapy, after the end of anthracycline therapy, and every 3 months for 12 months thereafter. CT was defined as a decrease in LV ejection fraction (EF) by ≥10% to <53%.Results. CT risk before chemotherapy was considered low and moderate in 96% of patients. An increase in hs-сTnI was detected ≥1 times in 56,8% of patients: before chemotherapy — in 13,5%, after 1 and 2 courses of anthracycline therapy — in 13,9%, after 3, 4, 5 and 6 courses — in 44%, 62%, 71% and 66% of patients, respectively. The levels of hs-cTnI before and after administration of anthracyclines did not differ significantly. The development of LV dysfunction was observed in 16,3% of patients. There were following prognostic significance of an increase in hs-cTnI at any time of chemotherapy for a decrease in LV EF: sensitivity — 87,5%, specificity — 50%, the positive predictive value — 28%, the negative predictive value — 94,7%. The closest relationship was noted between CT and hs-cTnI value before the start of chemotherapy (β=0,45, p=0,005) and after the 3rd course of anthracycline therapy (β=0,56, p=0,002).Conclusion. An increase in hs-cTnI level before and during anthracycline thera py in patients with a low risk of cardiotoxicity has a prognostic value in relation to the development of left ventricular dysfunction. Hs-cTnI assessment should be performed before the start of therapy, and then starting from the 3rd course of anthracycline therapy in all patients, regardless of the risk of cardiotoxicity.
Relationship between the degree of myocardial damage according to contrast-enhanced cardiac magnetic resonance imaging and laboratory data in patients with acute myocardial infarction
Authors: Mochula O. V. , Sulejmanova A. S. , Sukhareva A. E. , Ryabov V. V. , Zavadovsky K. V. 
Published: December 2022

Aim. To evaluate the information value of a complex of clinical and biochemical parameters of myocardial damage in predicting the development of transmural myocardial damage according to magnetic resonance imaging (MRI) in patients with acute myocardial infarction (AMI).Material and methods. The study included patients admitted to the emergency cardiology department with acute coronary syndrome. All patients underwent invasive coronary angiography, laboratory tests, and dynamic determination of cardiac biomarkers. In the interval of 6,1±4 days from admission to the hospital, patients underwent contrast-enhanced cardiac MRI. According to the pattern of delayed contrast enhancement, patients were divided into two groups: with a transmural and subendocardial pattern.Results. The mean age of patients was 62,5±10,5 years, while 27 (71,1%) had ST-segment elevation AMI. Among the risk factors for coronary artery disease, dyslipidemia (89,5%), hypertension (68,4%), and smoking (57,9%) were the most common. Creatine phosphokinase-MB (CPK-MB), serum high-sensitivity cardiac troponin I (cTnI) and C-reactive protein (CRP) values after 24 h were significantly higher in patients with transmural hyperenhancement. Moderate positive relationship was found between the global size of left ventricular (LV) damage according to MRI data and the levels of CPK-MB after 24 h and 4 days, as well as with CRP after 24 h, 4 and 7 days, and cTnI level after 24 h and 4 days. In the group of patients with transmural pattern, the global size of LV damage was significantly higher. Patients of this group were characterized by higher prevalence of microvascular obstruction. In a univariate regression analysis, there were following significant predictors of transmural myocardial damage: CPK-MB after 4 days (p=0,023) and ST segment elevation (p=0,029). Multivariate regression analysis showed that the only independent predictor of transmural myocardial damage was an increase in CPKMB after 4 days (p=0,023).Conclusion. An independent predictor of LV transmural damage in AMI was an elevated level of CPK-MB after 4 days. However, this laboratory marker had unsatisfactory information completeness and predictive quality. In this regard, cardiac MRI in patients with AMI, compared with the standard clinical assessment, can be considered preferable for assessing the depth of myocardial damage, risk stratification, and prognosis.
Transgenic plants — a threat to local flora?
Authors: Cheryatova Yulya S. , Yembaturova Elena Yu. 
Published: December 2022

The paper covers major threats associated with wide-range introduction and cultivation of transgenic plants due to germplasm mixing with that of indigenous species of natural plant communities and risks of transgenic plants adverse impact on the environment. Among them are: influencing non-target species, invasive power, possibility of GMPs escaping into the environment by horizontal gene transfer as well as harmful effect on the soil biota.
Currently, herbicide- and pest-resistant genetically modified plants (GMP) became an integral part of contemporary agrotechnologies in many economies [1]. However, most countries lack national strategy providing science-based substantiated procedure of creating, distribution and safe production of GMP. Rapid development of agricultural biotechnology and GMP production offered many economical benefits but also caused concern due to their potential environmental impact. To date, truly negative effects of GMP production, revealed in the course of growing, are known: harmful effect of entomocide Cry-proteins (Bt endotoxins) on non-target biota, target phytophage resistance to insecticidal plants, phytophage species succession to replace the species eliminated in the agrocoenosis. Vertical transfer of GMP transgenes (repollination between transgenic plants and wild species or isogenic varieties), as well as slow decomposition of transgenic plants remains all these factors can have remote environmental consequences [2, 3]. Wind-dispersed pollen of insecticidal GMP contaminates soil and open water reservoirs by toxins, thus posing potential hazards for aquatic organisms and geobionts (including rhizospheric organisms).
Thus, uncontrolled GMP production and introduction, creates a real threat of losing biodiversity and genetic diversity of indigenous plants due to biological contamination. Therefore, GMP cultivation and monitoring in the fields is of exceptional importance and must be regulated by a science-based national strategy. This strategy would allow to exclude agroecological and environmental genetic risks, to keep the genetic diversity of natural plant communities.
One-Dimensional Site Response Analysis: Model Error Estimation
Authors: Bahrampouri Mahdi , Rodriguez-Marek Adrian 
Published: December 2022

ABSTRACT
Two essential elements of partially nonergodic probabilistic seismic hazard analysis are the estimation of local site effects and the quantification of their uncertainty. Local site effects usually are evaluated using numerical site response analyses, often assuming the 1D site response. This research addresses two questions regarding the estimation of local site effects: for which stations may 1D site response analysis be beneficial? What is the model uncertainty in 1D site response analysis? In answering these two questions, we compare empirical and theoretical transfer functions (TFs) at KiK-net stations and apply state-of-the-art statistical tools. Regarding the first question, previous research associated the applicability of 1D site response to the topography of the site, geological features, and the shape and frequency of the horizontal-to-vertical spectral ratio (HVSR) peak. Among 22 candidate parameters, we find the combination of topographical position index (also known as relative elevation) and the ratio of theoretical TF predominant frequency over HVSR predominant frequency to be the most efficient predictor. However, the accuracy of predictions made by these two parameters is only 60%, highlighting the need for additional research. To address the second question, we use theoretical and empirical TFs to obtain the model error in 1D site response analyses. Model error uncertainty (in natural log units) in predicting TF ranges from 0.1 at low frequencies up to 0.4 around 10 Hz.
Aspectos éticos frente al inicio o la suspensión de terapia antibiótica en pacientes al final de la vida
Authors: Erazo Muñoz Marcela 
Published: December 2022

Propósito/Contexto. El incremento de las enfermedades crónicas en estadio avanzado e incurable, en particular del cáncer, ha aumentado las necesidades de acompañamiento por equipos de cuidados paliativos, orientados a brindar confort y mejorar la calidad de vida; aunque el uso de algunas medidas orientadas al control sintomático se considera controversial.
Metodología/Enfoque. Está revisión está orientada a reflexionar sobre el dilema ético que se presenta en pacientes al final de la vida, relacionado con la conveniencia de iniciar, continuar o retirar el manejo antibiótico con referencia el marco ético de los principios de Beauchamp y Childress.
Resultados/Hallazgos. Diferentes estudios han encontrado que, en promedio, el 74 % de los pacientes con cáncer avanzado que son hospitalizados reciben manejo con antibióticos durante la última semana de vida y son escasos los estudios que han logrado demostrar el impacto positivo en el control sintomático y la recuperación del paciente con la implementación de esta medida.
Discusión/Conclusiones/Contribuciones. La proporcionalidad terapéutica debe relacionarse con el ejercicio de autonomía médica para definir si una intervención es fútil.
Tendencies and consequences of migration from Ukraine
Authors: Slaviuk Nataliia , Tashlyk Anastasiia 
Published: December 2022

The article devotes to the topic of migration from Ukraine. Currently the massive flow of emigrants from Ukraine can be observed, which was caused by the Russian aggression. Definitely, it will influence the Ukrainian economy. In the article the tendencies of emigration from Ukraine since the year 2000 and the current flow and problems are analyzed. The main consequences of emigration in the current conditions are evaluated. It is mentioned that the influence of migration can have a long-lasting effect on the economy of the country. It is obvious that it is important to return people to Ukraine and to take special measures on the governmental and municipal levels. The methodology of econometric analysis is used to analyze the influence of factors on the migration in the country in the pre-war period. It is obvious that the main reason for emigration nowadays is the war in the country, and the decision of people to return will be influenced by the safety in the country, social conditions and the state of economy. It is crucial to define the economic factors, which will influence the decision of people for migration or returning to Ukraine. It is noted that employment and income, economic growth and perspectives of reconstruction and development of the country are important.
JEL classification: F66, J61
Evaluation OfThe Physical Quality Of Banana Peel Extract (Musa Paradisiaca) In Cream For Fissures Heels
Authors: . Khomaini , Hasanah Syaifiyatul , Uswatun Hasanah Naili 
Published: December 2022

Kulit Pisang (Musa Paradisiaca) merupakan tanaman yang mengandung senyawa flavonoid. Penelitian ini menggunakan metode eksperimental laboratorium, Formula sediaan krim dibuat dengan variasi konsentrasi ekstrak etanol kulit buah Pisang 5%, 10%, dan 15%. Ekstrak kulit buah Pisang diperoleh dengan cara maserasi menggunakan pelarut etanol 70%. Semakin tinggi konsentrasi ekstrak kulit pisang digunakan maka mempengaruhi daya sebar yang semakin menurun dan stabilitas suhu memenuhi syarat parameter masing-masing uji. Berdasarkan data hasil pengamatan, dapat disimpulkan bahwa perbedaan konsentrasi ekstrak etanol kulit pisang sebagai zat aktif mempengaruhi parameter uji evaluasi meliputi uji organoleptis, uji pH, uji daya sebar, dan uji stabilitas suhu, tetapi semua formula memenuhi syarat parameter evaluasi masing-masing uji sehingga dapat diformulasikan dalam sediaan krim sebagai obat untuk tumit pecah-pecah dan kering. Penelitian uji sediaan krim esktrak etanol kulit buah Pisang menggunakan metode maserasi. Dapat disimpulkan bahwa sediaan krim ekstrak etanol kulit buah Pisang memenuhi parameter uji fisik stabil dan memiliki aktivitas yang sedang.
Mortality Assesment of Pediatric Septic Patients Through Pediatric Sofa+Anion Gap and Pelod-2 Scores
Authors: Siampa Johaan Pawe , Arie Utariani  , Elizeus Hanindito  
Published: December 2022

Highlight:

Sepsis and septic shock cause morbidity and mortality in pediatric patients.
The accuracy of pediatric sequential organ failure assessment and anion gap (pSOFA+AG) was compared with AG and pediatric logistic organ dysfunction-2 (AG+PELOD-2).
The mortality assessment of pediatric septic patients showed that pSOFA was more sensitive than PELOD-2, while pSOFA+AG was not more sensitive than PELOD-2.

Abstract:
Sepsis and septic shock are some of the causes of morbidity and mortality (50-60%) in pediatric patients treated in intensive care rooms. This study aimed to compare the accuracy of pediatric Sequential Organ Failure Assessment (pSOFA) score combined with anion gap (AG) score to Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score in the assessment of mortality in pediatric septic patients at the Resuscitation Room of Dr. Soetomo Geeneral Academic Hospital, Surabaya, Indonesia. This was a retrospective observational cohort study using pediatric sepsis diagnosis guidelines based on the 2016 Pediatric Sepsis Consensus and medical records between January-December 2018. All data of patients aged 1 month to 16 years with suspected infection at the Resuscitation Room were collected based on predisposing infections, signs of infection, and warning signs. Organ dysfunction was assessed by calculating the pSOFA+AG scores, PELOD-2 scores, and corrected anion gap (cAG) in the first 24 hours. Sepsis mortality was assessed by comparing the results of the pSOFA, pSOFA+AG, and PELOD-2. The results showed 94.9% sensitivity and 70.0% specificity (p<0.0001) in the pSOFA, 89.9% sensitivity and 71.3% specificity (p<0.0001) in the PELOD-2, 79.7% sensitivity and 65% specificity (p<0.0001) in the AG, 79.7% sensitivity and 73.8% specificity (p<0.0001) in the cAG, and 79.3% sensitivity (p<0.0001) in the pSOFA+AG. In conclusion, pSOFA was more sensitive than PELOD-2, while the use of pSOFA+AG was not more sensitive than PELOD-2 in assessing the mortality of pediatric septic patients.
Chondroregenerative Potential of Platelet-Rich Fibrin (PRF)-Impregnated Decelulrized Bovine Cartilage Scaffold Implanted Subcutaneously
Authors: Widyatmika Putu Ardhy Parama , Noer Muhammad Sjaifuddin , Hutagalung Magda Rosalina 
Published: December 2022

Highlights:

This research compared the hondroregenerative potential between bovine cartilage scaffold with platelet-rich fibrin (BCPRF) and autologous cartilage.
The formation of newly-regenerated chondrocyte, the thickness of type II collagen, and the rate of cartilage resorption following the subcutaneous implantation were assessed.
BCPRF is highly biocompatible and can be developed as an alternative to alloplastic porous polyethylene (Medpor) implant material.

Abstract:
The invention of alternative implants with regenerative potential comparable to autologous cartilage continues to be encouraged due to high morbidity of the donor site related to autologous harvesting process. This research attempted an invention of alternative implant using tissue engineering techniques in the form of endogenous regeneration by combining decellularized bovine cartilage scaffold with platelet-rich fibrin (BCPRF) that was implanted subcutaneously. The study aimed to compare the chondroregenerative potential between BCPRF and autologous cartilage in terms of the formation of newly-regenerated chondrocyte, the thickness of type II collagen produced, and the rate of cartilage resorption following the subcutaneous implantation. This study was conducted in a pretest-posttest control group design using New Zealand white rabbits. Forty-eight experimental samples were divided into two groups, then treated with subcutaneous implantation of BCPRF and autologous cartilage respectively. The results were evaluated after six weeks of implantation. Thirty-nine samples were evaluated. There was a significant difference found from both groups in terms of the formation of newly-regenerated chondrocyte, the thickness of type II collagen (p=0.000), and the implant resorption rate (p=0.000). The microscopic images demonstrated a superior chondroregenerative potential in the group receiving implantation of autologous cartilage compared to the group receiving BCPRF. The chondroregenerative potential for autologous cartilage and BCPRF differed significantly in terms of the formation of newly-regenerated chondrocyte, the deposition of type II collagen matrix, as well as the resorption rate.