bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-vivo recording of sensory signals from peripheral nerves using flexible 3D neural electrodes
Authors: Park Byungwook , Jang Jae-Won , Kim Sohee 
Published: November 2022

AbstractTo overcome the limitations of muscle-based prostheses, studies on nerve-based prostheses for sensory feedback have recently been reported. To develop such prostheses, intrafascicular electrodes, a type of peripheral nerve interface, are essentially used to connect the nervous system and external systems. Through these electrodes, sensory feedback to induce sensations in patients is possible. To evoke natural sensations, precise recordings of nerve signals should precede sensory feedback, in order to identify patterns of sensory signals in the nerve and to mimic these patterns in stimulating the nerve. For this purpose, we previously developed a PDMS-based flexible penetrating microelectrode array (FPMA). In the current study, we verified the ability of the FPMA to record sensory nerve signals. The FPMA implanted in the rabbit sciatic nerve was able to record spontaneous neural signals, and the recorded signals were separated into action potential units. In addition, sensory nerve signals synchronized with ankle movement were successfully recorded, demonstrating that the FPMA is a useful peripheral neural interface capable of recording high-resolution sensory signals.
Bionic design based on micro-nano structure of osteon and its low-velocity impact damage behavior
Authors: Liu Yuxi , Li Aihua , Li Yanhua , Chen Song 
Published: November 2022

AbstractIt is found that the osteon is composed of thin and thick lamellae which are periodic and approximately concentric, every 5 lamellae is a cycle, the periodic helix angle of mineralized collagen fibers in two adjacent sub-lamellae is 30°. Four bionic composite models with different fiber helix angles were established and fabricated according to the microstructure of mineralized collagen fibers in osteon. Based on the impact analysis of four kinds of bionic composite models, the effects of the fiber periodic spiral structure on the impact resistance and energy dissipation of multi-layer bionic composite were investigated. The analysis results show that the fiber helix angle affects the impact damage resistance and energy dissipation of multi-layer fiber reinforced composites. Among the 4 kinds of multi-layer composite models, the composite model with helix angle of 30° has better comprehensive ability to resist impact damage. The test results show that the impact damage area of the specimen with 30° helix angle is smallest among the 4 types of bionic specimens, which is consistent with the results of finite-element impact analysis. Furthermore, in the case of without impact damage, the smaller the fiber helix angle is, the more uniform the stress distribution is and more energy is dissipated in the impact process. The periodic spiral structure of mineralized collagen fibers in osteon are the result of natural selection of biological evolution. This structure can effectively improve the ability of cortical bone to resist external impact. The research results can provide useful guidance for the design and manufacture of high-performance and strong impact resistant bionic composites.
Graphical Abstract
Are immediate postoperative X-Rays valuable in evaluating complications of primary total hip arthroplasty?
Authors: Brown Matthew L. , Michel David , Narayanan Arvind , McCauley Julie C. , Bugbee William D. 
Published: November 2022

Abstract
Purpose
This study aimed to investigate the complications of primary total hip arthroplasty based on immediate postoperative X-rays. The overall quality and cost of X-rays were assessed.

Methods
The institutional database was queried to identify all patients who underwent total hip arthroplasty in a single institution between January 1, 2018, and December 31, 2018. Immediate postoperative X-rays were reviewed to identify the complications such as periprosthetic fractures, dislocation, and fixation failure. The quality and cost of X-ray were assessed. The complications were categorized as "known" and "unknown" according to the intraoperative fluoroscopic results.

Results
A total of 518 total hip arthroplasties were included in this study. Based on intraoperative fluoroscopy, periprosthetic fractures were found in 10 (2%) THAs. Compared to the X-rays taken immediately after surgery, 9 periprosthetic fractures (recorded as "known") were found and 1 was not (recorded as "unknown"). There was no significant difference between intraoperative fluoroscopy and X-rays (P > 0.05). Of the 518 X-rays, 225 (43%) were of suboptimal quality. The cost of a single portable pelvic X-ray was $647.

Conclusion
In total hip arthroplasty, X-rays taken immediately after surgery rarely reveal unknown complications. The X-rays are often of suboptimal quality, have minimal clinical utility, and are less cost-effective.
Quasi-4-dimension ionospheric modeling and its application in PPP
Authors: Gu Shengfeng , Gan Chengkun , He Chengpeng , Lyu Haixia , Hernandez-Pajares Manuel , Lou Yidong , Geng Jianghui , Zhao Qile 
Published: November 2022

AbstractIonospheric delay modeling is not only important for Global Navigation Satellite System (GNSS) based space weather study and monitoring, but also an efficient tool to speed up the convergence time of Precise Point Positioning (PPP). In this study, a novel model, denoted as Quasi-4-Dimension Ionospheric Modeling (Q4DIM) is proposed for wide-area high precision ionospheric delay correction. In Q4DIM, the Line Of Sight (LOS) ionospheric delays from a GNSS station network are divided into different clusters according to not only the location of latitude and longitude, but also satellite elevation and azimuth. Both Global Ionosphere Map (GIM) and Slant Ionospheric Delay (SID) models that are traditionally used for wide-area and regional ionospheric delay modeling, respectively, can be regarded as the special cases of Q4DIM by defining proper grids in latitude, longitude, elevation, and azimuth. Thus, Q4DIM presents a resilient model that is capable for both wide-area coverage and high precision. Four different sets of clusters are defined to illustrate the properties of Q4DIM based on 200 EUREF Permanent Network (EPN) stations. The results indicate that Q4DIM is compatible with the GIM products. Moreover, it is proved that by inducting the elevation and azimuth angle dependent residuals, the precision of the 2-dimensional GIM-like model, i.e., Q4DIM 2-Dimensional (Q4DIM-2D), is improved from around 1.5 Total Electron Content Units (TECU) to better than 0.5 TECU. In addition, treating Q4DIM as a 4-dimensional matrix in latitude, longitude, elevation, and azimuth, whose sparsity is less than 5%, can result in its feasibility in a bandwidth-sensitive applications, e.g., satellite-based Precising Point Positioning Real-Time Kinematic (PPP-RTK) service. Finally, the advantages of Q4DIM in PPP over the 2-dimensional models are demonstrated with the one month's data from 30 EPN stations in both high solar activity year 2014 and low solar activity year 2020.
Perceived occupational prestige of physiotherapy in Nigeria among physiotherapy undergraduates: implication for public and healthcare professionals’ awareness of the role of physiotherapy
Authors: Odunaiya Nse A. , Oladele Abimbola Kafilat , Sanuade Comfort Titilope , Adesanya Temilade Boluwatife , Odole Adesola C. 
Published: November 2022

Abstract
Background
The occupational prestige of any occupation is of interest to its members and prospective members. A profession’s occupational prestige influences its desirability, marketability, professional autonomy and social esteem, and career selection among prospective university undergraduates. This study aimed to assess the perception of the occupational prestige of physiotherapy in Nigeria among physiotherapy undergraduates and to explore its determining factors.

Methods
This study employed a mixed method design. The quantitative component involved 280 students from four universities in Nigeria, while the qualitative part involved 35 students. The participants in the survey completed a questionnaire on occupational prestige, and the data obtained were analysed using descriptive and inferential statistics. In addition, the qualitative data was analyzed using content thematic analysis.

Results
The perception of occupational prestige obtained from the cross-sectional survey showed that 12.1% of the participants perceived it as low, 49.3% as intermediate, and 38.6% as high. Overall, 49.3% of the participants ranked physiotherapy fourth, following medicine, engineering and law. The qualitative component corroborated these findings and further explained that the perceived status resulted from public perception of the profession in relation to other jobs, especially within the health care team.

Conclusion
Physiotherapy is ranked intermediate occupational prestige by most physiotherapy undergraduates. The significant determinants of this ranking are poor knowledge and awareness of physiotherapy among other health care professionals and the general public. To enhance the occupational prestige of physiotherapy, there is a need for public awareness of physiotherapy and its role and inter-professional education among health care professionals.
Prevalence of knowledge on maternal physical activity among pregnant women: a protocol for a systematic review
Authors: Perera Madhawa , Dissanayake Kumara , Senarathna Lalith 
Published: November 2022

Abstract
Background
Maternal physical activity is beneficial to pregnant women, fetus and newborns. Evidence suggests that the level of physical activity in this group is not up to the expectation around the world. Lack of knowledge on the benefits of physical activity during pregnancy and not being aware of the recommendations are major reasons for this situation. Although individual studies have reported various levels of knowledge on maternal physical activity in different populations, no studies have systematically reviewed the literature to provide global evidence on the topic that is useful in initiating multinational approaches to improve maternal physical activity. The proposed study aims to systematically review prevalence of knowledge on maternal physical activity among pregnant women in different regions in the world.

Methods
The proposed systematic review is designed according to the guidelines for conducting systematic reviews of prevalence and will be reported following the recommendations in the PRISMA statement. Quantitative cross-sectional, descriptive and observational studies published from year 2000 to 2022 will be included in the review. PubMed, Scopus, CINAHL, Embase, SPORTDiscus and Web of Science Core Collections will be searched using keywords relevant to physical activity, pregnant women and knowledge. Grey literature on the topic will be located through searching grey information sources, hand searching of reference lists and communicating with experts in the field. Screening of search results, selection and quality assessment of studies and data extraction will be independently performed by two reviewers. Assistance of a third reviewer will be sought to resolve any disagreement during the selection and quality assessment steps. After appraising the quality and consistency of selected studies, a premade data collection form will be used for data extraction. Narrative synthesis approach will be used in this review to analyze the evidence in primary studies.

Discussion
The proposed review will summarize evidence on the level of knowledge on maternal physical activity among pregnant women in different populations and delineate interregional discrepancies. The study will locate high priority regions with poor knowledge and identify elements of knowledge that needs attention.
LBSUN132 Adipocyte-specific Ablation Of Fgf23 Attenuates Diet-induced Obesity In Female Mice
Authors: Park Min Young , Tu Chia-Ling , Chang Wenhan , Sitara Despina 
Published: November 2022

Abstract
Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate homeostasis and vitamin D metabolism. In addition to its central role in mineral balance, recent findings suggested that FGF23 is associated with chronic metabolic conditions including cardiovascular disease, diabetes mellitus, and obesity. Circulating FGF23 levels are elevated in obese individuals, and they are correlated with body fat mass and abdominal obesity. Moreover, consumption of high fat diet (HFD) increases serum FGF23 levels. However, the actions of FGF23 in adipocytes and its role in lipid metabolism have not been demonstrated. To understand the role of FGF23 in adipocytes, particularly in obesity, we generated adipocyte-specific Fgf23 null mice using Cre recombinase under the control of the mouse adiponectin (Adipoq) promoter. Both male and female control (Fgf23flox/flox) and knockout (KO, AdipoqCreFgf23flox/flox) mice were fed either HFD (60%kcal fat) or normal fat diet (NFD) at 8 weeks of age for 24 weeks. Body weight measurements were taken every week and percentage of body fat was determined after longitudinally during 24 weeks of diet interventation using in vivo by an EchoMRI scannermicroCT. Serum, adipose tissue, and liver were collected upon sacrifice. After 24 weeks of HFD, male control and KO mice had comparable gain in body weight (BW) and body fat percentage. However, female KO mice had significantly lower body weight and percentage of body fat. Moreover, serum total cholesterol levels were reduced in female KO mice. Triglyceride (TG) content in the liver was significantly reduced in female KO mice, and it corresponded with downregulation of lipid droplet protein Perilipin and fatty acid transporter CD36 mRNA expression in the liver. Transcript levels of hepatic PPARγ, which is positively correlated with fat accumulation in obesity, were also suppressed in female KO mice compared to controls. Obesity is associated with low-grade chronic inflammation, and we found that hepatic mRNA expression of the inflammatory cytokine TNFα was diminished in female KO mice, suggesting that adipocytic Fgf23 modulates lipid accumulation and inflammation. In summary, our results demonstrate for the first time that adipocyte-specific ablation of Fgf23 alleviates attenuates diet-induced obesity and regulates lipid metabolism in a sex-specific manner.
Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m.
ODP001 AKR1C2 Activity in Abdominal Adipose Tissue of Women with or without Excess Visceral Adiposity
Authors: Ostinelli Giada , Gauthier Marie-Frédérique , Bouvet-Bouchard Léonie , Julien François , Tchernof André 
Published: November 2022

Abstract

Background
Adipose tissue is known to play an active role in androgen turnover, as illustrated by the presence of enzymes of the aldo-keto reductase 1C family such as AKR1C2 and AKR1C3, respectively coding for 3α-hydroxysteroid dehydrogenase type 3 and 17β-hydroxysteroid dehydrogenase type 5. Our group demonstrated that these enzymes are mainly expressed in mature adipocytes and that in women, trunk fat percentage is positively associated with adipose tissue mRNA abundance of both AKR1C2 and AKR1C3. In this context, our aim was to assess whether abdominal adipose tissue activity of AKR1C2 relates to excess visceral adiposity index (VAI) in women.

Methods
AKR1C2 activity was measured in visceral (VAT) and subcutaneous adipose tissue (SAT) of 31 women (age: 39 ± 7; BMI: 51 ± 6) undergoing bariatric surgery. Adipose tissue homogenate activity was measured by fluorimetry in a 12-hour kinetic experiment using the chemical compound cumberone, a competitive substrate in the inactivation of 5a-dihydrotestosterone to 3α-androstanediol by AKR1C2. Visceral adipose tissue excess was quantified using the previously published VAI equation and using the age-specific cut-offs for women, who were categorized into either high VAI or low VAI. Other markers of adipose tissue dysfunction included diacylglycerol acyltransferase 2 (DGAT2) and glutathione peroxidase 3 (GPX3) mRNA abundance, adipocyte size and pericellular fibrosis.

Results
Our technique allowed us to detect significant AKR1C2 activity in SAT (13.5±5.7 fluorescence units (FU)/min) and VAT (8.3±4.8 FU/min). Using the VAI equation, we identified 18 women with high VAI and 13 with low VAI. Women with high VAI were characterized by significantly higher VAT AKR1C2 activity when compared to women with low VAI (9.5 ± 4.4 vs. 6.4± 3.6 FU/min, p&lt;0. 05). AKR1C2 mRNA abundance in either VAT or SAT was not significantly different as a function of VAI. Women with high VAI also had larger VAT adipocyte diameter and lower mRNA abundance of GPX3 in both adipose tissue depots compared to women with low VAI (p&lt;0. 05 for all). No differences were seen in DGAT2 mRNA abundance, pericellular fibrosis or SAT adipocyte diameter as a function of VAI.

Conclusion
In women with severe obesity, excess visceral adiposity as indicated by a high VAI, is associated with higher AKR1C2 activity in VAT only. Similarly, adipose tissues of women with high VAI displayed features of adipose tissue dysfunction such as increased VAT adipocyte diameter and decreased GPX3expression in comparison to women with low VAI. Taken together our results confirm the link between adipose AKR1C2 and excess visceral adiposity.
Presentation: No date and time listed
ODP006 Multidisciplinary Weight Management Improves Body Weight And Body Mass Composition In Breast Cancer Women Undergoing Adjuvant Chemotherapy
Authors: Nguyen Vivien , Chen Juliana , Preda Veronica 
Published: November 2022

Abstract
Weight gain during chemotherapy for breast cancer is a well-documented adverse side effect. The prevalence of metabolic syndrome (MetS), including glucose intolerance, hypertension and dyslipidaemia in breast cancer patients are further exacerbated by menopause. This impact on mortality is relevant as many women with early-stage breast cancer may be treated however experience a greater risk of developing chronic disease, higher rates of cancer recurrence, and post-diagnosis death. Intentional weight loss of 5-10% body weight and muscle mass preservation has found to improve metabolic markers. We evaluated how multidisciplinary weight management involving endocrinology, dietitian and exercise physiology care, in a real-life Healthy Weight Clinic (HWC) could affect body weight and mass composition outcomes in breast cancer women receiving adjuvant chemotherapy compared to a cohort of non-cancer women who have been matched by age, ethnicity, smoking and menopausal status. Body weight (kg), BMI (kg/m 2), skeletal muscle mass (SMM %), fat mass (FM %) and waist circumference (cm) were collected at three time points: baseline 0-months at the first HWC appointment, 3-months after baseline, and 6-months after baseline. A total of 32 women were included in the study, 11 in the breast cancer cohort and 21 in the control cohort. There were significant changes in weight, BMI, SMM, FM and waist circumference for the breast cancer cohort at all time intervals. By 6-months, the breast cancer women had a mean weight change of -6.99kg (SD=3.87, p=. 003, n=11) and change in BMI by -2.72kg/m 2 (SD=1.62, p=. 004, n=11). There was a change in SMM of 1.21% (SD=0.73, p=. 005, n=11), a change in FM of -2.76% (SD=1.33, p=. 002, n=11) and a change in waist circumference of -8.13cm (SD=4.21, p=. 031, n=3). The control cohort had similar trend changes in weight, BMI and waist circumference, however there was no statistically significant change in SMM or FM over time. By 6-months in the breast cancer cohort, there was a larger reduction in body weight in women who did not have MetS (-8.72kg, SD=2.41, n=6) in comparison to women with MetS (-2.65kg, SD=3.75kg, n=3) (p=. 045). For the control cohort, anthropometric outcomes were not impacted by MetS status (p&gt;. 05). Although these findings are in a small sample size, it appears that multidisciplinary weight management has a positive role in early-stage breast cancer survival through improving body weight and mass composition outcomes. Targeting pre-existing MetS status through lifestyle changes is also an important consideration, beyond a specific weight focus.
Presentation: No date and time listed
LBODP009 Resection Of An Adrenocorticotropic Hormone Secreting Pheochromocytoma In A Jehovah'S Witness Patient
Authors: Andalahao Edzele Marie Fernandez 
Published: November 2022

Abstract
Background: Pheochromocytomas are rare neuroendocrine tumors arising from chromaffincells in the adrenal medulla, and the excessive catecholamine secreted causes serious cardiovascular effects to the patient. Adrenalectomy is the definitive treatment with a morbidity rate of 40% and a mortality rate of 2%. Intraoperative bleeding is a major concern with any surgical procedure, thus preparation of blood products for possible transfusion during the perioperative period is prudent. A religious group known as the Jehovah's witnesses recommend blood transfusion refusal to its members. We encountered a case of a Jehovah's witness with pheochromocytoma requiring adrenalectomy. CASE: A case of 54 year old, Filipino male, a Jehovah's witnesses, hypertensive for 14 years, complained of 1 week vague right upper quadrant abdominal pain and bouts of headache. A CT scan of the abdomen with contrast revealed an 11.7x 12.2×10.3cm mass on the right adrenal. Biochemical tests were consistent with pheochromocytoma that is co-secreting with ACTH, but with no physical features of hypercortisolism. An elevated levels of 24 hours urine Metanephrine (8.95 mg/ 24hrs),24 hours urine cortisol (173.98 mcg /24 hours), serum ACTH (57 pg/ml), 8am serumcortisol (22.44 mcg/dl), and 1 mg Dexamethasone suppression 8am cortisol (18.85mcg/dl). Patient consented to surgery but signed a waiver of refusal to any blood transfusion. Erythropoietin 5000 IU SC three times per week was then initiated 1month prior to the surgery. Terazosin 25 mg three times a day followed by Metoprolol25 mg twice daily, for adequate alpha and beta blockade, and hydration prior to surgery was done. The Estimated blood loss during surgery was 600 ml, patient's hemoglobin level dropped to 98 g/L on the 7th post-operative day from pre-operative level of 125 g/L, hence, the Erythropoietin was continued until was discharged. The Histopathology report showed round cell neoplasm, with positive immunohistochemical stain for synaptophysin and chromogranin, and a weak positive of NSE (Neuro-specific enolase) consistent with pheochromocytoma. References: 1. Narita et al, Surgery without Blood Transfusion for Giant Paraganglioma in a Jehovah's Witness Patient, Case Rep Oncol 2014;7: 233–238, DOI: 10.1159/0003608132. Bachman et al, Pheochromocytoma, Fulminant Heart Failure, and a Phenylephrine Challenge. The Perioperative Management of Adrenalectomy in a Jehovah's Witness Patient: A Case Report, The Journal of Critical Care Medicine 2022; 8(1): 55-60, DOI: https://doi.org/10.2478/jccm-2021-0038
Presentation: No date and time listed