bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic Kidney Disease and Pregnancy. Guideline of the DGGG, OEGGG, DGfN (S2k Level, AWMF Registry No. 015 – 090)
Authors: Schmidt Markus , Stracke Sylvia , Schneider Uwe , Kuschel Bettina , Feldkamp Thorsten , Habbig Sandra , Mayer-Pickel Karoline , Hartung Andreas , Bader Birgit , Weinmann-Menke Julia , Korst Uwe , Vom Dorp Frank , Schäfer-Graf Ute Margaretha 
Published: August 2022

Abstract
Aim As diagnostic and therapeutic options have improved in recent years, women with limited renal function of varying etiologies are now able to become pregnant. Depending on the
extent of disease and the patientsʼ comorbidities, the care of these women can be especially challenging. This guideline aims to improve the interdisciplinary care offered to pregnant women
with kidney disease.
Methods A selective literature search was carried out. This S2k guideline was then compiled using a structured consensus-based process which included representatives from different
medical specialties and professional societies.
Recommendations Recommendations for the care of pregnant women with renal disease were developed to cover preconception counseling, the recording of risks, special aspects of
prenatal care and prenatal screening, as well as the specific treatment options for the underlying disease in women wanting to have children and pregnant women.
Hexoprenaline Compared with Atosiban as Tocolytic Treatment for Preterm Labor
Authors: Kirchhoff Ebba , Schneider Verena , Pichler Gerhard , Reif Philipp , Haas Josef , Joksch Maike , Mager Corinna , Schmied Christian , Schöll Wolfgang , Pichler-Stachl Elisabeth , Gold Daniela 
Published: August 2022

Abstract
Introduction Preterm birth is defined as a live birth before 37 weeks of gestation and is associated with increased neonatal morbidity and mortality. The aim of this study is to
compare the efficacy of hexoprenaline and atosiban for short- and long-term tocolysis and their effects on neonatal and maternal outcomes.
Methods This retrospective cohort study included women with threatened preterm labor between 24 + 0 and 34 + 0 weeks of gestation without premature rupture of membranes. The
tocolytic efficacy of hexoprenaline and atosiban was compared in women receiving one of the two medications for short- and long-term tocolysis. Continuous variables were compared using
t-test or Mann–Whitney U test, as appropriate. Comparison of categorical variables between the two groups was done with χ2 test after Pearsonʼs and Fisherʼs exact test.
Results 761 women were enrolled in this study; 387 women received atosiban and 374 women received hexoprenaline as their primary tocolytic agent. Atosiban showed a higher efficacy as
a primary tocolytic agent (p = 0.000) within 48 hours. As regards long-term tocolysis, there were no differences between the treatment groups (p = 0.466). Maternal side effects such as
tachycardia (p = 0.018) or palpitations (p = 0.000) occurred more frequently after the administration of hexoprenaline, while there were no differences between the two drugs administered
with regard to any other maternal or neonatal outcome parameter.
Conclusion Our retrospective study shows a significantly higher efficacy of atosiban in the first 48 hours, especially when administered at an early gestational age. There were no
significant differences in terms of neonatal outcome but significantly more maternal adverse effects during the administration of hexoprenaline.
Strengthening the Resilience of Children and Adolescents during a
Pandemic: A Scoping Review on Eligible Interventions
Authors: Bischops Anne Christine , Reinauer Christina , Pischke Claudia , Mayatepek Ertan , Meißner Thomas 
Published: August 2022

Abstract
Background The COVID-19 pandemic dramatically affects children’s
and adolescents’ mental health. The accumulation of stress factors and a
lack of social support complicate a healthy development. Since the beginning of
the pandemic, there has been almost a doubling of mental health problems in
children and adolescents. Promoting resilience is a possible approach to reduce
the incidence of mental health problems despite these adverse circumstances.
Objectives This literature search aims at identifying and evaluating
interventions to promote resilience mechanisms, with a special focus on
feasibility in a crisis situation.
Materials and methods This scoping review is based on a systematic
literature search including the databases Cochrane Library, PubMed, Psyc-Info,
Psyndex and Google Scholar (2006–2020). Of 1733 identified articles 75
were included.
Results Out of 72 identified intervention studies 28% were
feasible under pandemic conditions. The most effective resilience trainings seem
to be individualized interventions using cognitive behavioral therapy elements.
However, many approaches primarily show short-term success.
Discussion Few evidence-based programs are feasible online or under
pandemic restrictions. Most of them show short-term effects and focus on parents
and individuals. Multiple programs are ready for use, but still lack proof of
efficacy. The development and improvement of (digital) resilience interventions
should be an essential part of preventive health care, especially for risk
groups.
Assessment of the Association of Periodontal Diseases in Pregnant Women and the Efficacy of Periodontal Treatment in the Context of Premature Births and Pregnancy Complications – a Narrative Review
Authors: Kranz Angela , Feierabend Nathalie , Sliwka Doreen , Wiesegart Anja , Abele Harald , Graf Joachim 
Published: August 2022

AbstractIntroduction Periodontal diseases are widespread in women of reproductive potential. Although their treatment of these disorders contributes to oral health, there is still no conclusive evidence that this intervention has a beneficial effect on the course of pregnancy, in particular the rate of premature births. On the one hand, the aim of the paper is a systematic assessment of the association between periodontal diseases and pregnancy complications, based on the current literature. On the other hand, the efficacy of periodontal treatments vs. no treatment in pregnant women should be assessed with the target criterion of premature birth or other pregnancy complications.Materials and methods The narrative review was based on the PRISMA statement. Premature births were defined as primary endpoints, while various perinatal and maternal outcomes were grouped together as secondary endpoints. An electronic database search for relevant meta-analyses and systematic reviews was carried out in PubMed and the Cochrane database. Methodological characteristics and the results of the included studies were extracted. The RR or OR (95% CI) was used to measure the result. The quality of the included studies was assessed according to the AMSTAR checklist.Results Seven publications were included (total number of subjects n = 56755). The majority of included studies do not demonstrate a significant association of periodontal disease and/or periodontal treatment with certain childhood and/or maternal outcomes. The quality of the included studies was deemed to be sufficient.Conclusion Even today, there is insufficient evidence to confirm the correlation between periodontal disease and certain maternal and/or infantile outcomes. Periodontal treatment during pregnancy also does not seem to affect the risks of pregnancy. Nevertheless, it is recommended that all pregnant women are advised to improve their daily oral hygiene in order to prevent inflammatory diseases, regardless of the progress of the pregnancy.
Entlassen und doch eingesperrt“ – Auswirkungen der
SARS-CoV-2-Pandemie auf Klienten forensischer
Nachsorgeambulanzen
Authors: Barra Steffen , Retz-Junginger Petra , Retz Wolfgang 
Published: August 2022

ZusammenfassungDie Coronavirus-Pandemie (SARS-CoV-2) stellt für die Gesellschaft eine
Herausforderung dar, die bei manchen Menschen mit psychischen Belastungen
einhergeht. Ein besonderes Risiko besteht dabei für Menschen in
forensischen Settings, insbesondere für diejenigen, die kurz vor oder
während der Pandemie aus der Haft oder Unterbringung entlassen wurden.
Wenngleich theoriegeleitete Annahmen zu den Effekten der SARS-CoV-2-Pandemie auf
das Erleben dieser Menschen zu Behandlungsempfehlungen im Sinne eines
adäquaten Risikomanagements geführt haben, mangelt es bisher an
empirischen Befunden, die diese Annahmen und Empfehlungen unterstützen.
Der vorliegende Beitrag behandelt deshalb die Wahrnehmung von Klienten
forensischer Nachsorgeambulanzen bezüglich SARS-CoV-2-assoziierter
Einschränkungen in verschiedenen Bereichen und Veränderungen
bzgl. therapie- und deliktassoziierter Einstellungen, des psychischen
Wohlbefindens und des Ressourcenbewusstseins im Verlauf der aktuellen Pandemie.
Insgesamt beschrieben die meisten Befragten eine Zufriedenheit mit der Therapie
trotz SARS-CoV-2-bedingter Einschränkungen. Es zeigte sich eine gewisse
Stabilität des psychischen Wohlbefindens, wobei eine höhere
SARS-CoV-2-assoziierte Belastung mit einem geringeren psychischen Wohlbefinden
einherging. Zudem kam es im Verlauf zu einer Abnahme eines anfänglich
beschriebenen Ressourcenbewusstseins, welche im Rahmen deliktrelevanter
Risikoeinschätzungen von besonderer Relevanz ist. Implikationen
für die Gestaltung der psychiatrisch/psychotherapeutischen
(deliktpräventiven) Nachsorge, die einerseits den Klient*innen
eine bestmögliche, personen- und situationsadäquate Behandlung
bietet und damit andererseits zum Schutz der Gesellschaft vor möglicher
erneuter Delinquenz beiträgt, werden diskutiert.
Doença de Hirayama: Relato de caso*
Authors: Rodrigues Victor Alves , Klettenberg Matheus Rocha Pereira , Farage Luciano , Seguti Lisiane 
Published: August 2022

ResumoPaciente de 26 anos, previamente hígido, que, aos 18 anos, iniciou perda progressiva de força distal, tremor de repouso, e atrofia muscular no membro superior esquerdo. Ao exame, apresentou atrofia moderada, distal, força muscular de grau 4, e minipolimioclonus. A eletroneuromiografia (ENMG) revelou comprometimento pré-ganglionar crônico de C7/C8/T1 bilateral pior à esquerda, com sinais de desnervação ativa em C8/T1. A ressonância magnética (RM) de coluna cervical mostrou alterações degenerativas espondilodiscais com protrusões centrais em C4-C5, C6-C7, e central direita em C5-C6, que tocavam o saco dural. O diâmetro anteroposterior da medula na posição neutra, no plano de C5-C6, era de 5,1 mm. Houve redução do calibre da medula para 4,0 mm após a manobra dinâmica de flexão forçada da coluna, e aumento de sinal nos cornos anteriores. Os achados clínicos e os dos exames complementares eram compatíveis com doença de Hirayama (DH), uma doença benigna rara dos neurônios motores, que afeta os segmentos espinhais cervicais e é mais prevalente em homens e de início próximo aos 20 anos. É típica a fraqueza unilateral e lentamente progressiva, porém autolimitada. Perturbações sensoriais, sinais autonômicos e do neurônio motor superior são raras.O manejo geralmente é conservador, com uso de colar cervical macio. Apesar de rara, a DH deve ser considerada em pacientes jovens que apresentam atrofias assimétricas focais de membros superiores. O diagnóstico precoce de DH depende do grau de suspeição, e da cooperação e comunicação entre as diversas especialidades envolvidas na investigação.
The Mesentery in Complete Mesocolic Excision
Authors: Fletcher Jordan , Miskovic Danilo 
Published: August 2022

AbstractThe following article summarizes technical aspects of how to operate in the mesentery during complete mesocolic excision (CME). Increasingly, CME is being adopted and as such it is important to establish the anatomical basis of the techniques involved. This review thus serves to provide that foundation and explains the surgical techniques built on it.
The Mesentery in Robot-Assisted Total Mesorectal Excision
Authors: Crolla Rogier M.P.H. , Coffey J. Calvin , Consten Esther J. C. 
Published: August 2022

AbstractIn recent decades, surgery for rectal cancer has evolved from an operation normally performed under poor vision with a lot of blood loss, relatively high morbidity, and mortality to a safer operation. Currently, minimally invasive rectal procedures are performed with limited blood loss, reduced morbidity, and minimal mortality. The main cause is better knowledge of anatomy and adhering to the principle of operating along embryological planes. Surgery has become surgery of compartments, more so than that of organs. So, rectal cancer surgery has evolved to mesorectal cancer surgery as propagated by Heald and others. The focus on the mesentery of the rectum has led to renewed attention to the anatomy of the fascia surrounding the rectum. Better magnification during laparoscopy and improved optimal three-dimensional (3D) vision during robot-assisted surgery have contributed to the refinement of total mesorectal excision (TME). In this chapter, we describe how to perform a robot-assisted TME with particular attention to the mesentery. Specific points of focus and problem solving are discussed.
Investigation on the influence of gas temperature characteristics for engine combustion chamber on plasma jet deflection with MHD control
Authors: Zhao Kai , Lu Yongji , Wang Chunyu , Li Feng 
Published: August 2022

This paper is devoted to investigating the influence of gas temperature on plasma jet under magnetic control. The combustion temperature and the conductivity of the chemical equilibrium state were calculated by using a numerical method. K2CO3 was selected as the ionization seed. The characteristics of gas plasma in ionization were compared for methane/air/K2CO3 and acetylene/air/K2CO3 combustion schemes. The results showed that the acetylene/air/K2CO3 combustion scheme can obtain higher gas temperature and conductivity. The functional relationship between the conductivity and the gas temperature is fitted in polynomial form. The experiments on the deflection of plasma were carried out on the combustion and flow control test rig at temperatures of 1600–2500 K and in a magnetic field of intensity 0.6 T. The effect of jet deflection was analyzed from macroscopic and microscopic points of view. When the gas temperature increases, the ionization degree increases, the positive Lorentz force in ions increases, and plasma jet deflection becomes more obvious. The Lorentz force on the positive ion determines the effect of plume deflection. The calculated and experimental results indicated that the high temperature condition is very helpful to improve the characteristics of gas plasma in ionization. The results provide references for corresponding experimental research.
An intermediate-effect size variant in
UMOD
confers risk for chronic kidney disease
Authors: Olinger Eric , Schaeffer Céline , Kidd Kendrah , Elhassan Elhussein A. E. , Cheng Yurong , Dufour Inès , Schiano Guglielmo , Mabillard Holly , Pasqualetto Elena , Hofmann Patrick , Fuster Daniel G. , Kistler Andreas D. , Wilson Ian J. , Kmoch Stanislav , Raymond Laure , Robert Thomas ,   Genomics England Research Consortium, Eckardt Kai-Uwe , Bleyer Anthony J. , Köttgen Anna , Conlon Peter J. , Wiesener Michael , Sayer John A. , Rampoldi Luca , Devuyst Olivier , Ambrose J. C. , Arumugam P. , Bevers R. , Bleda M. , Boardman-Pretty F. , Boustred C. R. , Brittain H. , Brown M.A. , Caulfield M. J. , Chan G. C. , Giess A. , Griffin J. N. , Hamblin A. , Henderson S. , Hubbard T. J. P. , Jackson R. , Jones L. J. , Kasperaviciute D. , Kayikci M. , Kousathanas A. , Lahnstein L. , Lakey A. , Leigh S. E. A. , Leong I. U. S. , Lopez F. J. , Maleady-Crowe F. , McEntagart M. , Minneci F. , Mitchell J. , Moutsianas L. , Mueller M. , Murugaesu N. , Need A. C. , O’Donovan P. , Odhams C. A. , Patch C. , Perez-Gil D. , Pereira M. B. , Pullinger J. , Rahim T. , Rendon A. , Rogers T. , Savage K. , Sawant K. , Scott R. H. , Siddiq A. , Sieghart A. , Smith S. C. , Sosinsky A. , Stuckey A. , Tanguy M. , Taylor Tavares A. L. , Thomas E. R. A. , Thompson S. R. , Tucci A. , Welland M. J. , Williams E. , Witkowska K. , Wood S. M. , Zarowiecki M. 
Published: August 2022

The kidney-specific gene
UMOD
encodes for uromodulin, the most abundant protein excreted in normal urine. Rare large-effect variants in
UMOD
cause autosomal dominant tubulointerstitial kidney disease (ADTKD), while common low-impact variants strongly associate with kidney function and the risk of chronic kidney disease (CKD) in the general population. It is unknown whether intermediate-effect variants in
UMOD
contribute to CKD. Here, candidate intermediate-effect
UMOD
variants were identified using large-population and ADTKD cohorts. Biological and phenotypical effects were investigated using cell models, in silico simulations, patient samples, and international databases and biobanks. Eight
UMOD
missense variants reported in ADTKD are present in the Genome Aggregation Database (gnomAD), with minor allele frequency (MAF) ranging from 10
−5
to 10
−3
. Among them, the missense variant p.Thr62Pro is detected in ∼1/1,000 individuals of European ancestry, shows incomplete penetrance but a high genetic load in familial clusters of CKD, and is associated with kidney failure in the 100,000 Genomes Project (odds ratio [OR] = 3.99 [1.84 to 8.98]) and the UK Biobank (OR = 4.12 [1.32 to 12.85). Compared with canonical ADTKD mutations, the p.Thr62Pro carriers displayed reduced disease severity, with slower progression of CKD and an intermediate reduction of urinary uromodulin levels, in line with an intermediate trafficking defect in vitro and modest induction of endoplasmic reticulum (ER) stress. Identification of an intermediate-effect
UMOD
variant completes the spectrum of
UMOD
-associated kidney diseases and provides insights into the mechanisms of ADTKD and the genetic architecture of CKD.
Growth promoter alternatives after the ban on antibiotics.
Authors: Wenk C. 
Published: August 2022

Abstract
Feed additives are used world-wide for many different reasons. Some help to cover the needs for essential nutrients and others to increase animal performance, feed intake and thereby optimize feed utilization. They can positively affect technological properties and quality of feed as well as animal products. In many countries the use of feed additives is more and more questioned by the consumers: substances such as antibiotics, hormones and ß-agonists with perceived high risks are banned in animal diets. The trend in consumer demand is for safer and more organic food. Environmental aspects and animal management conditions become essential in intensive animal production systems. Therefore, the feed industry is eagerly looking for effective alternatives which are acceptable to the consumer and environmentally sound. Organic acids, enzymes, probiotics, prebiotics and highly available minerals as well as herbs or botanicals can be seen as potential alternatives to metabolic modifiers and antibiotics. The best results can be achieved by the use of these feed additives under good environmental conditions.
The welfare of pigs during transport and slaughter.
Authors: Grandin Temple 
Published: August 2022

Abstract
To maintain a high standard of animal welfare during the transportation and slaughter of pigs requires both the proper equipment and supervision of employees. The use of numerical scoring of handling and stunning can help maintain high standards because it will enable management to determine whether or not practices are improving or deteriorating. The following variables should be measured: (1) The percentage of pigs stunned correctly, (2) percentage that remain insensible, (3) percentage that are prodded with an electric goad, (4) percentage that fall during handling and (5) percentage vocalizing. For electric stunning, sufficient amperage must be passed through a pig's brain to induce an epileptic seizure. For carbon dioxide, a 90% concentration is recommended. Other gas mixtures are reviewed. Handling facilities must be designed so that pigs move easily without baulking or backing up and have non-slip floors. Research on the following topics is reviewed: electric stunning, carbon dioxide stunning, pig behaviour during handling, return to sensibility, facility design, truck loading, density and transport stress.
Micronutrient-sensitive food value chains: A systematic review of intervention strategies and impact pathways to nutritional outcomes
Authors: Kumar Shalander , Das Abhishek , Kasala Kavitha , Ravula Padmaja 
Published: August 2022

Abstract
Knowledge and evidence on how food value chains can deliver nutrition, especially micronutrients, are limited. A deeper understanding of the food value chains as part of agri-food systems approaches addressing hunger and malnutrition through agricultural development may provide pathways for nutrition and health outcomes.. This systematic review was undertaken using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to assess the broad topic of value chains and micronutrients, focusing on interventions and their related impact pathways. Impact pathway interventions improving micronutrient delivery and consumption were classified as production, accessibility, marketing, income, knowledge and behavioral, and finally, women’s empowerment pathways. However, the case study evidence on the micronutrient-sensitive value chains for nutritional outcomes is very scant. This review identified that making value chains micronutrient-sensitive requires a multi-stakeholder, integrated approach as a basis for concerted action among various stakeholders in terms of policy, research, strengthening partnerships and coordination, and information sharing. The review illustrates the scarcity of literature with a focus on the micronutrients in the context of food value chains and developing countries. The food value chain approach offers great potential to unpack the complexity of food systems and identify entry points and pathways for improving nutrition outcomes, especially the micronutrients. Additionally, this review identifies multiple entry points and calls for strong advocacy of nutrition-sensitive value chain approaches to combat hidden hunger.
A systematic review on the diversity and importance of mycotoxins in tomato and derived products
Authors: Alizadeh Aliye , Shakeri Golshan , Marhamati Masoumeh , Afshari Asma 
Published: August 2022

Abstract
Molds and their toxins, mycotoxins, are of major global challenges in the food industry due to their harmful effects on human health as well as their economic losses. Tomato and its products are prone to fungal spoilage at industrial and consumer levels. In this study, we aim to emphasize the presence and significance of mycotoxins not only in spoiled tomato-based products but also in the products without visible growth of fungi. According to our systematic review, main mycotoxins in tomatoes and their derivatives are Alternariol (AOH), Alternariol methyl ether (AME), Tenuazonic acid (TeA), and Patulin (PAT). Among them, TeA has the highest concentration in tomato-based products. Thus, it should be deemed as a health risk. We also outlined some of the current and potential antimicrobial techniques and their inhibitory effects on mycotoxins in tomato and derived products. Finally, we emphasize the need for further studies on the health risk assessment of most concerning mycotoxins (TeA and AOH) in tomato-derived products. The results of our review can highlight the gaps and align with the prevention of health risks, increasing product shelf-life, and avoiding economic losses in the tomato-based industry.