bluuebunny/crossref_metadata_2025_split huggingface dataset:
Greater Palatine Canal: Computed Tomography-Based Anatomic Analysis And Clinical Significance for the Sinus and Skull Base Surgeon
Authors: Machado André , Simmen Daniel , Schuknecht Bernhard , Briner Hans Rudolf 
Published: September 2022

Objective Our aim is to describe the location and course of the greater palatine canal (GPC) by analyzing its relationship with anatomical landmarks that can be used during endoscopic sinus surgery. This information might help prevent injury to the neurovascular bundle. Methods A retrospective evaluation of paranasal sinus CT scans of 100 consecutive random patients, 200 sides, was performed. Five measurements related to the course of the GPC were conducted, from cranial to caudal. The anatomical landmarks were the inferior bony border of the sphenopalatine foramen to the cranial entrance of the GPC, the distance from the most dorsal, and inferior bony insertion of the middle turbinate and the inferior turbinate bones to the anterior margin of the GPC. The angle between the horizontal palatine bone and the GPC, its length, and the prevalence of osteophytes in GPC was also assessed. Results The mean distance of the inferior border of the sphenopalatine foramen to the cranial entrance of the GPC was 9.39 ± 1.72 mm. The mean distance of the dorsal insertion of the middle turbinate to the anterior margin of the GPC was 3.89 ± 0.93 mm. The distance of the dorsal insertion of the inferior turbinate to the anterior margin of the GPC was 3.16 ± 0.81 mm. The mean angle between the horizontal palatine bone and the GPC was 114.33 ± 10.92º and the mean length of the GPC was 30.23 ± 3.74 mm. None of the measurements showed a significant difference between the two sides. Conclusions The landmarks used are easy to locate and assess on CT scans. These findings may help to make dissection safer in pathologies related to the pterygopalatine fossa, lateral sphenoid sinus or adjacent skull base.
A Longitudinal Model of School Climate, Social Justice Orientation, and Academic Outcomes among Latina/o Students
Authors: Pérez-Gualdrón Leyla , Helms Janet E. 
Published: September 2022

Background Social justice orientation (SJO) is the motivation to promote justice and equity among all in society. Researchers argue that students of Color with high SJO can resist structural racism in their schools/society and have positive academic outcomes. Purpose In the present study, a longitudinal model of cultural and environmental predictors (i.e., school relational climate, school language climate, Spanish language background, and English proficiency) and civic/educational outcomes (i.e., community engagement, grades, school engagement, school dropout) of SJO among Latina/o youths was developed and tested. Participants The study was conducted with a subsample of Latinas/os taken from the National Education Longitudinal Study of 1988. Participants were enrolled in eighth grade (N = 1,472), sampled from different schools and regions in the U.S., and followed through three waves of data collection from 8th through 12th grade. Research Design A longitudinal, correlational design was used to explore the association among the constructs studied. Data Collection and Analysis Secondary data analyses were conducted. Structural equation modeling techniques were used to analyze the data. Results Early school relational climate (8th grade) was a positive predictor of SJO, which in turn predicted more community and school engagement, higher grades, and decreased likelihood of dropping out of school (12th grade) via personal agency. In addition, school language climate and language skills predicted a greater sense of personal agency, which in turn predicted higher grades and a decreased likelihood of dropping out. Conclusions The results of the present study underscore the importance of strengths-based and cultural approaches in education in a sample of Latina/o students. Specifically, close attention should be paid to school cultural climate variables in which positive relational climates and cultural language climates are addressed in schools. The integration of sociopolitical context, critical consciousness, and SJO may be key factors in improving the educational and counseling experiences of Latina/o youths.
Teacher Advice-Seeking: Relating Centrality and Expertise in Middle School Mathematics Social Networks
Authors: Berebitsky Dan , Andrews-Larson Christine 
Published: September 2022

Background/Context Teachers’ relationships with principals, instructional coaches, and other teachers have important implications for the improvement of their instructional practice and student learning. In particular, teachers who access content-specific instructional expertise through their social networks are more likely to exhibit and sustain evidence of instructional improvement; teachers who seek advice from colleagues with knowledge of both content and pedagogy have evidenced growth in their own knowledge and improved classroom instructional practice. Purpose/Objective In this paper, we extend the literature by examining how formal role relates to the relationship between expertise and advice-seeking in the context of urban middle school mathematics teachers’ social networks. Specifically, we first explore how network centrality varies across formal role group (i.e., teacher, instructional coach, and principal/assistant principal), and second, we investigate how centrality relates to expertise within each formal role group. Research Design We draw on a variety of data sources taken from a 4-year observational study of a sample of 30 schools and 533 teachers, coaches, and administrators in four large urban school districts. In particular, we rely on data from a network survey to document teachers’ advice-seeking behaviors, and we draw on the broader data set to document formal role and measures of expertise within each role group. Findings/Results The main findings are: (a) coaches were significantly more central than teachers, who are significantly more central than administrators; (b) teachers with greater expertise were more central; (c) while coach expertise was not related to centrality, teachers were more likely to nominate a coach if they perceived the coach to have expertise and be evaluative; and (d) administrators were rarely nominated. Conclusions/Recommendations Findings indicate that teachers are accessing information from those with expertise and experience, which suggests that advice-seeking among teachers may be self optimizing. Furthermore, teachers’ advice-seeking seems to be shaped both by their efforts to access expertise and in response to accountability pressures. This calls for caution against the misalignment of formal role and expertise. Our findings suggest that those in a social network whose social status is elevated to the formal role of coach are more sought out for advice, particularly if they are perceived to have evaluative power. This can inform what administrators can expect of teachers’ informal advice-seeking as well as how advice-seeking patterns are likely to shift if a teacher is made a coach.
How best to capture the impact of complementary therapies in palliative care: A systematic review to identify and assess the appropriateness and validity of multi-domain tools
Authors: Mitchinson Lucy , Chu Christina , Bruun Andrea , Sisk Ali-Rose , Armstrong Megan , Vindrola-Padros Cecilia , Kupeli Nuriye , Candy Bridget , Stone Patrick 
Published: September 2022

Background: Complementary therapies are widely used in palliative care settings. Qualitative research found that people with advanced disease report a range of physical and psychological benefits from complementary therapies, however evidence of their effectiveness from clinical trials is inconclusive. This may be because trials are limited by use of inappropriate outcome measures. Aims: To identify tools which capture the impact of massage, reflexology and aromatherapy in people with advanced disease. We (1) identified multi-domain tools used to evaluate these therapies in populations with any chronic health condition and (2) assessed whether tools were valid and psychometrically robust in populations with advanced disease. Design: A two-stage systematic review was conducted using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidelines (PROSPERO: CRD42020161199). Data sources: Six databases were searched (August 2021). Study methodological quality, tool psychometric properties and evidence quality were assessed. A global comparison score was generated. Results: Stage 1: 66 trials using 40 different multi-domain tools were identified. Stage 2: Of these tools, we identified papers for seven tools regarding development or validation in advanced disease populations. The majority of psychometric data were inconsistent or inconclusive. Data were mostly of low quality due to methodological issues. Conclusion: Of the tools identified, ‘Functional Assessment of Cancer Therapy – General’ appears to be the most suitable alternative tool against COMSIN criteria, for trials of massage, reflexology and aromatherapy in palliative care. Further tool validation is required before firm recommendations can be made. Co-development of a core outcome set could ensure relevant domains are assessed.
Zhuangzi's Ethics: A Reading of “In the Human World”
Authors: Yun Zou 
Published: September 2022

AbstractThis brief essay aims to interpret the fourth chapter “In the Human World” of Zhuangzi by analyzing the seven fables in philosophical terms. The seven fables can be divided into two groups: the first three are concerned with how to be useful (youyong zhi yong 有用之用); the following four with “the use of the useless” (wuyong zhi yong 无用之用). From those two groups of fables, two different ways of life are identified in relation to the world. Zhuangzi's choice between them can be revealed in light of his art of speaking.
The impact of the COVID-19 pandemic on breast cancer screening and diagnosis in a Brazilian metropolitan area
Authors: Solla Negrao Erika Marina , Cabello Cesar , Conz Livia , Mauad Edmundo Carvalho , Zeferino Luiz Carlos , Vale Diama Bhadra 
Published: September 2022

Objectives To evaluate the performance of breast cancer screening and early diagnosis during the pandemic, compared to the pre-pandemic period. Setting: The public referral centre for screening in Campinas, São Paulo State, Brazil. Methods This is an audit study of performance screening and diagnostic indicators. Two periods were analysed: 2019, the pre-COVID period, and 2020, the COVID period. All women who underwent mammography in these periods were included. Indicators were compared between periods, and the US Breast Cancer Surveillance Consortium benchmarks were used as a reference. Results A comparison between the periods shows a reduction of 57.4% in screening and 4.4% in diagnosis using mammography. Cancer detection rate per 1000 screening mammograms dropped from 4.62 to 2.83 (p  =  0.031), while it increased from 84.43 to 89.36 in diagnosis mammograms (p  =  0.701), higher than the reference (34.4, p < 0.001). With regard to diagnosis, the proportion of minimal cancers was reduced (p  =  0.005) and was lower than the reference (40.0%, p < 0.001), along with the proportion of node-negative invasive cancers (p < 0.001). The mean size of invasive tumours was similar in the two periods (32.50 mm and 33.40 mm, p  =  0.808) but larger than the reference value (16.50 mm, p < 0.001). Recall rate was lower in the COVID period (22.55% vs. 27.37%, p  =  0.015). Conclusion The COVID pandemic caused an overall decrease in breast screening and detection of breast cancer cases, although the reduction in number of diagnosis mammograms performed was minimal. Tumour mean size was large in both periods, the pandemic highlighting a previous profile of detection at an advanced stage.
Validation of a biomechanical testing protocol of craniodorsal hip luxation in feline cadavers and comparison of two ultra-high molecular weight polyethylene materials used for extra-articular hip stabilisation
Authors: Letesson Julien , Goin Bastien , Viguier Eric , Cachon Thibaut 
Published: September 2022

Objectives The aim of our study was to describe a biomechanical testing protocol to reproduce ex vivo craniodorsal hip luxation specific to the feline model, and evaluate the biomechanical properties of an intact hip joint compared with the fixation strength of two different techniques of extra-articular hip stabilisation. Methods Eighteen hip joints (femur and hemipelvis) were harvested from nine mature feline cadavers. CT was performed for each hip joint so that a biomechanical base specific to each joint morphotype could be created using computer-aided design. The biomechanical bases were then produced using a three-dimensional printer to secure the hip joints during testing. A total of 34 biomechanical compression tests were performed. Eighteen compression tests were performed in the control group, of which two fractured. The remaining 16 hip joints were then randomly assigned either to group A (hip joints stabilised with an extra-articular ultra-high molecular weight polyethylene (UHMWPE) implant secured by an interference screw [n = 8]) or to group B (hip joints stabilised with a UHMWPE iliofemoral suture [n = 8]). Results Mean ± SD yield, failure load and linear stiffness in the control group were 616 ± 168 N, 666 ± 158 N and 231 ± 50 N/mm, respectively. The relative fixation strength (% of intact joint) before hip luxation in groups A and B was 43.8% and 34.7%, respectively. No statistical difference was found between groups A and B for yield and failure load. However, the reoccurrence of craniodorsal hip luxation was higher in group B than in group A, in 5/8 and 0/8 tests, respectively. Moreover, in group A, the extra-articular UHMWPE implant induced caudodorsal hip luxation, reported as failure mode in 7/8 cases. Conclusions and relevance This modified biomechanical protocol for testing craniodorsal hip luxation in a feline model was validated as repeatable and with acceptable variance. The extra-articular UHMWPE implant stabilisation technique proved to be more efficient in avoiding reoccurrence of craniodorsal hip luxation than UHMWPE iliofemoral suture.
Cardiac troponin I in healthy Norwegian Forest Cat, Birman and domestic shorthair cats, and in cats with hypertrophic cardiomyopathy
Authors: Hanås Sofia , Larsson Anders , Rydén Jesper , Lilliehöök Inger , Häggström Jens , Tidholm Anna , Höglund Katja , Ljungvall Ingrid , Holst Bodil S 
Published: September 2022

Objectives The aims of this study were to assess the potential associations between the serum cardiac troponin I (cTnI) concentration in healthy cats and feline characteristics, systolic blood pressure, heart rate (HR), echocardiographic measurements and storage time; and to compare cTnI concentrations in healthy cats with concentrations in cats with hypertrophic cardiomyopathy (HCM), with or without left atrial enlargement (LAE) and in cats with HCM, to assess potential associations between cTnI concentration and echocardiographic variables. Methods Cardiac TnI was analysed using an Abbott ARCHITECT ci16200 analyser in serum from prospectively included healthy Norwegian Forest Cat (NF; n = 33), Birman (n = 33) and domestic shorthair (DSH; n = 30) cats, and from 39 cats with HCM, with or without LAE. Results In healthy cats, higher cTnI concentrations were found in Birman cats than in NF cats ( P = 0.014) and in neutered male cats than in intact females ( P = 0.032). Cardiac TnI was positively associated with HR ( P <0.0001). In cats with HCM, cTnI concentration was positively associated with left ventricular wall thickness and with left atrial-to-aortic root ratio (all P ⩽0.010). Cats with HCM had higher cTnI concentrations than healthy cats, and cTnI concentrations were higher in cats with HCM and LAE than in those with HCM without LAE (all P = 0.0003). Conclusions and relevance Breed and sex may affect serum cTnI concentrations in healthy cats. The cTnI concentration increased with increasing severity of HCM.
The Relationship Between D-dimer and Prognosis in the Patients with Serum Alpha-Fetoprotein-Positive Gastric Cancer: A Retrospective Cohort Study
Authors: Zhang Xiaofang , Wang Weigang , Tian Baoguo , Wang Yan , Jing Jiexian 
Published: September 2022

Background: Alpha-fetoprotein-positive gastric cancer (AFPGC) is a subtype of gastric cancer that is rare in clinical practice and extremely malignant. Malignant tumors are often associated with hemorrhage, thrombosis, and even disseminated intravascular coagulation (DIC). The D-dimer test is used as a sensitive index in the diagnosis of DIC and fresh thrombosis in malignant tumors. Therefore, this study aims to investigate the relationship between D-dimer values and the clinical characteristics and prognosis of patients with serum AFPGC (AFP ⩾ 15 μg/L) patients. Methods: Overall, 120 healthy subjects and 120 AFP-negative gastric cancer (AFP < 15μg/L) patients from May 2017 to July 2018 at the Shanxi Cancer Hospital served as the control group in this retrospective cohort study. Additionally, 120 patients with pretreatment advanced serum AFP were chosen to analyze clinicopathologic features and factors that affect prognosis. The predictor was the D-dimer, and the outcome variable was overall survival (OS). Other variables included age, sex, tumor site, T-stage, distant metastasis, and preoperative serum tumor biomarkers. Differences in OS rate were analyzed by GraphPad Prism 9.2.0.332. The Cox regression model was used for univariate and multivariate analysis. Results: In comparison to AFP-negative gastric cancer, we discovered that D-dimer had a meaningfully higher presentation in patients with AFPGC ( P < .001). Based on D-dimer median levels, the AFPGC patients were divided into two groups, including 39 patients with low D-dimer (<1000 ng/mL) and 81 patients with high D-dimer (⩾1000 ng/mL). The variables, including T-stage, distant metastasis, and expression of HER2, were associated with the value of D-dimer. The D-dimer levels were weakly related to the levels of tumor markers. The differences in AFPGC patients, with an OS rate of 30.76% for patients with low D-dimer (<1000) and 12.30% with high D-dimer (⩾1000; P = .0027), were statistically significant. Cox multivariate analysis of various parameters indicated that T-stage, distant metastasis, vascular embolism, level of D-dimer, and tumor biomarkers of AFP were independent risk factors for survival. Conclusion: Serum D-dimer levels may be a valuable indicator for predicting AFPGC metastasis and progression.
Private Sector Presence in Healthcare in India: Econometric Analysis of Patterns and Consequences
Authors: Yadav Priyanka , Ray Amit Shovon 
Published: September 2022

The presence of private providers in the Indian healthcare sector remains one of the most debated issues. This article attempts to contribute to this debate from the angle of the ultimate goal of healthcare provision—a healthy population. We explore whether private sector presence (PSP) has improved the general health status of the people. We develop a theoretical argument to hypothesize that PSP in India would lead to better health status through the route of competition-driven quality, which in turn could lead to adverse economic consequences. We use district-level secondary data from government sources to confirm our hypotheses using robust tools of applied econometrics, correcting for serious problems of endogeneity. Constructing a district-level index of PSP, we identify distinct spatial/geographical clusters, explained by socio-economic prosperity as well as demonstration effect. We also find a robust positive association between PSP and general health outcomes, accompanied by an adverse economic consequence of rising catastrophic out-of-pocket expenditure. In terms of policy, the article concludes that rather than restricting the growth of the private sector, the government must strengthen the quality of the existing public healthcare delivery system and ensure effective monitoring and regulation. JEL Codes: 110, 111, 112, 115
Marital status and genetic liability independently predict coronary heart disease incidence
Authors: Silventoinen Karri , Lahtinen Hannu , Korhonen Kaarina , Smith George Davey , Ripatti Samuli , Morris Tim , Martikainen Pekka 
Published: September 2022

Aims: Married individuals have a lower coronary heart disease (CHD) risk than non-married, but the mechanisms behind this are not fully understood. We analyzed whether genetic liability to CHD may affect these associations. Methods: Marital status, a polygenic score of CHD (PGS-CHD), and other risk factors for CHD were measured from 35,444 participants (53% female) in Finnish population-based surveys conducted between 1992 and 2012. During the register-based follow-up until 2020, there were 2439 fatal and non-fatal incident CHD cases. The data were analyzed using linear and Cox regression models. Results: Divorced and cohabiting men and women had a higher genetic risk of CHD than married individuals, but the difference was very small (0.023–0.058 standard deviation of PGS-CHD, p-values 0.011–0.429). Both marital status and PGS-CHD were associated with CHD incidence, but the associations were largely independent. Adjusting for behavioral and metabolic risk factors for CHD explained part of these associations (11–20%). No interaction was found between marital status and PGS-CHD for CHD incidence. Conclusions: We showed minor differences between the marital status categories in PGS-CHD and demonstrated that marital status and genetic liability predicted CHD incidence largely independently. This emphasizes the need to measure multiple risk factors when predicting CHD risk.
ARG1 and CXCL2 are potential biomarkers target for psoriasis patients
Authors: Wang Huilin , Chen Wenjun , Lie Caihua , Zhang Yijie , Li Jiajia , Meng Jilong , Zhang Nan 
Published: September 2022

Background Psoriasis is a common chronic skin inflammatory disease. Understanding the pathogenesis of psoriasis and identifying novel therapeutic targets are under investigation. Methods Gene expression profiles were obtained from GSE13355, GSE30999 and GSE54456 datasets to identify differentially expressed genes (DEGs) between psoriasis and normal controls. Enrichment analysis was used to identify the biological functions and pathways of common genes from three groups of DEGs. Protein-protein interaction (PPI) network was then constructed to identify key genes according to degree of connectivity. Expression of genes was detected by the method of qRT-PCR and immunohistochemistry. The infiltration of immune cells of psoriasis were quantified and detected by flow cytometry. Results A total of 146 common genes were identified between psoriasis and normal controls. They were significantly enriched in IL-17, chemokine, and NOD-like receptor (NLR) signaling pathway. Ten key genes were selected with bigger degree of connectivity through PPI network, and ARG1 and CXCL2 had better predictive ability based on ROC curves. Increased expression of ARG1 and CXCL2 in psoriasis patients were verified by qRT-PCR and immunohistochemistry method. In addition, a lot of immune cells were upregulated in psoriasis compared to healthy controls through ssGSEA and flow cytometry. Conclusion ARG1 and CXCL2 may serve as biomarkers and potential therapy for psoriasis. This may be related to the immune response and NLR pathway.