bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salidroside ameliorates pathological cardiac hypertrophy via TLR4‐TAK1‐dependent signaling
Authors: Guo Zhen , Liu Fang‐Yuan , Yang Dan , Wang Ming‐Yu , Li Chen‐Fei , Tang Nan , Ma Shu‐Qing , An Peng , Yang Zheng , Tang Qi‐Zhu 
Published: December 2022

AbstractSalidroside, a prominent active ingredient in traditional Chinese medicines, is garnering increased attention because of its unique pharmacological effects against ischemic heart disease via MAPK signaling, which plays a critical role in regulating the evolution of ventricular hypertrophy. However, the function of Salidroside on myocardial hypertrophy has not yet been elucidated. C57BL/6 mice were subjected to transverse aortic constriction (TAC), and treated with Salidroside (100 mg kg−1 day−1) by oral gavage for 3 weeks starting 1 week after surgery. Four weeks after TAC surgery, the mice were subjected to echocardiography and then sacrificed to harvest the hearts for analysis. For in vitro study, neonatal rat cardiomyocytes were used to validate the protective effects of Salidroside in response to Angiotensin II (Ang II, 1 μM) stimulation. Here, we proved that Salidroside dramatically inhibited hypertrophic reactions generated by pressure overload and isoproterenol (ISO) injection. Salidroside prevented the activation of the TAK1‐JNK/p38 axis. Salidroside pretreatment of TAK1‐inhibited cardiomyocytes shows no additional attenuation of Ang II‐induced cardiomyocytes hypertrophy and signaling pathway activation. The overexpression of constitutively active TAK1 removed the protective effects of Salidroside on myocardial hypertrophy. TAC‐induced increase of TLR4 protein expression was reduced considerably in the Salidroside treated mice. Transient transfection of small interfering RNA targeting TLR4 (siTLR4) in cardiomyocytes did not further decrease the activation of the TAK1/JNK‐p38 axis. In conclusion, Salidroside functioned as a TLR4 inhibitor and displayed anti‐hypertrophic action via the TAK1/JNK‐p38 pathway.
Achievements and future directions in self‐reconfigurable modular robotic systems
Authors: Dokuyucu Halil İ. , Özmen Nurhan Gürsel 
Published: December 2022

AbstractIn this study, a comprehensive review of achievements in the self‐reconfigurable modular robotics field and future directions are given. Self‐reconfigurable modular robots (SRMRs) are known as autonomous kinematic machines that can change their shape by rearranging the connectivity of their modules to perform new tasks, adapt to changing circumstances, and recover from damage. Versatility, reliability, and low‐cost are the fundamental promises of SRMRs when compared with conventional robots. This study emphasized the achievements in the field considering the promises and identified the gaps to be filled in the future. The main distinguishing feature of an SRMR is the capability of configuring its shape during operation. Flexibility in shape supported by appropriate controller strategies brings flexibility in task assignment. Classification of SRMRs is enriched by adding a new section based on assigned tasks to the robot. In addition, the classification based on mechanical and controller design aspects is thoroughly inspected in our study. A new subsection of material selection is introduced in the mechanical design aspects section. Adding these sections to the classification is the main difference between our study and the previous review studies. It is expected that the SRMRs field will have more interactions with materials science in the future. The study is concluded by emphasizing the promises of SRMRs and giving a future vision of the field.
Synergy of Ultrathin CoOx Overlayer and Nickel Single Atoms on Hematite Nanorods for Efficient Photo‐Electrochemical Water Splitting
Authors: Mao Lianlian , Huang Yu‐Cheng , Deng Hao , Meng Fanqi , Fu Yanming , Wang Yiqing , Li Mingtao , Zhang Qinghua , Dong Chung‐Li , Gu Lin , Shen Shaohua 
Published: December 2022

AbstractTo solve surface carrier recombination and sluggish water oxidation kinetics of hematite (α‐Fe2O3) photoanodes, herein, an attractive surface modification strategy is developed to successively deposit ultrathin CoOx overlayer and Ni single atoms on titanium (Ti)‐doped α‐Fe2O3 (Ti:Fe2O3) nanorods through a two‐step atomic layer deposition (ALD) and photodeposition process. The collaborative decoration of ultrathin CoOx overlayer and Ni single atoms can trigger a big boost in photo‐electrochemical (PEC) performance for water splitting over the obtained Ti:Fe2O3/CoOx/Ni photoanode, with the photocurrent density reaching 1.05 mA cm−2 at 1.23 V vs. reversible hydrogen electrode (RHE), more than three times that of Ti:Fe2O3 (0.326 mA cm−2). Electrochemical and electronic investigations reveal that the surface passivation effect of ultrathin CoOx overlayer can reduce surface carrier recombination, while the catalysis effect of Ni single atoms can accelerate water oxidation kinetics. Moreover, theoretical calculations evidence that the synergy of ultrathin CoOx overlayer and Ni single atoms can lower the adsorption free energy of OH* intermediates and relieve the potential‐determining step (PDS) for oxygen evolution reaction (OER). This work provides an exemplary modification through rational engineering of surface electrochemical and electronic properties for the improved PEC performances, which can be applied in other metal oxide semiconductors as well.
Evaluation of ultralightweight foamed glass aggregates in precast concrete
Authors: Mathews Grady , Wertz Brady , Khan Taha , Jafari Khashayar , Loux Theresa , Bylone Robert 
Published: December 2022

AbstractThis project investigates the use of foamed glass aggregates in lightweight precast concrete. Precast mixes are evaluated for compression and split‐tension strength, and durability is assessed through rapid chloride permeability, thermal conductivity, alkali silica reactivity, and freeze–thaw performance. Mixes containing a 100% or 50% replacement of gravel with foamed glass aggregates are evaluated. The 100% mixes have a 28‐day compression strength = 23.3–27.89 MPa which is acceptable per structural lightweight concrete standards (ASTM C330), but the split‐tension strength falls short of ASTM C330 requirements. The 50% mixes have acceptable strength but exceed the maximum density allowed for lightweight concrete in ASTM C330. The mixes exhibited low–moderate permeability but poor freeze–thaw resistance. All of the proposed mixes with one exception have acceptable expansion due to alkali silica reactivity. The thermal conductivity of the mixes varies from typical lightweight to normal weight concrete ranges with respect to the aggregate replacement ratio.
Waste high impact polystyrene (HIPS) microfiltration membranes for water treatment: A thorough experimental study
Authors: Khaled Mostafa , Noby Hussien , Mansor Eman S. , Elshazly Ahmed H. , Aissa Walid A. 
Published: December 2022

AbstractIn our previous work, the prepared high‐impact polystyrene (HIPS) membranes, synthesized using four concentrations (20, 25, 30, and 35 wt%) of waste HIPS, were proved to be promising for water purification by microfiltration process (MF). However, the fabricated membranes' mechanical properties and microfiltration process parameters were not investigated. Consequently, in this study, various parameters affecting the previously fabricated membranes' performance in the filtration process, such as membrane mechanical properties, feeding pressure, fouling behavior, and polymer concentration, were thoroughly investigated. With increasing polystyrene concentrations, the ultimate tensile strength of the fabricated membranes increased. When the concentration was increased from 20 to 25 wt percent, the elongation at break rose, but as the concentration was increased further, the membrane became brittle. Permeate flux and rejection both declined as polymer content was raised. Accordingly, the highest flux and humic acid (HA) rejection were shown by 20 wt% (14.18 L/m2h (LMH) and 98.95%, respectively). The antifouling properties declined when the polymer concentration was raised, and 20 wt% had the lowest total fouling resistance. Furthermore, the permeate flux was reduced while increasing the HA initial concentration.
Blood‐based electro‐osmotic flow of non‐Newtonian nanofluid (Carreau‐Yasuda) in a tapered channel with entropy generation
Authors: Abbasi Aamar , Al‐Khaled Kamel , Zouidi Ferjeni , Khan Sami Ullah , Khan M. Ijaz , Bafakeeh Omar T. , Farooq Weseh , Choudhari Rajashekhar 
Published: December 2022

AbstractThe motivation of current contribution is to signify the assessment of entropy generation in the flow of generalized Newtonian fluid generated under the influence of electro‐osmosis and peristalsis. The flow has been confined by a tapered channel with certain flow assumptions. The fundamental conservations laws of mass, momentum, energy and concentration along with the Poisson and Nernst‐Planck equations are used to identify the problem in given domain. The Poisson equation is solved analytically for potential function under the Debye‐Huckel linearization approximation while the expressions are attained with association of conservation concept under widely used assumptions of minor Reynolds number and long wavelength. The velocity in axial direction, temperature and nanoparticles profiles are numerically approximated using shooting method. The electric force parameter and radiative constant are being expressed against different flow, temperature and concentration features via various sketches. The results for Newtonian and Carreau fluid as particular case are also presented via numerous plots and tables. It is expected that the obtained theoretical results are very useful for the resilience of medical instatements.
The Hidden Energies of Work Digitisation: A View from France Through the Use of Coworking Spaces
Authors: Ortar Nathalie , Flipo Aurore 
Published: December 2022

AbstractThere is no shortage of terms—collaborative economy, sharing economy or cognitive capitalism—to describe the new work practices brought about by the spreading digital economy. The French ‘Third place’ movement, reuniting diverse collaborative workplaces, has been claiming the search for more sustainable ways of living as a goal. Recently, numerous public funding programmes have been deployed to support such places. This chapter focusses on coworking spaces and their users to unfold energy consumption discourses and practices of coworkers, based on a survey conducted during 2017–2020 in the Auvergne-Rhône-Alpes region. It demonstrates lack of awareness of the ‘hidden energies’ of work digitalisation. Though most coworkers display eco-friendly values, attitudes towards digital technology reflect divergences within the forms of appropriation of norms of transition towards sustainability.
Bridging Koopman Operator and Time-Series Auto-Correlation Based Hilbert–Schmidt Operator
Authors: Zhen Yicun , Chapron Bertrand , Mémin Etienne 
Published: December 2022

AbstractGiven a stationary continuous-time process f(t), the Hilbert–Schmidt operator Aτ can be defined for every finite τ. Let λτ,i be the eigenvalues of Aτ with descending order. In this article, a Hilbert space
$$\mathcal {H}_f$$

ℋ

f

and the (time-shift) continuous one-parameter semigroup of isometries
$$\mathcal {K}^s$$

K

s

are defined. Let
$$\{v_i, i\in \mathbb {N}\}$$

{

v

i

,
i
∈
ℕ
}
be the eigenvectors of
$$\mathcal {K}^s$$

K

s

for all s ≥ 0. Let
$$f = \displaystyle \sum _{i=1}^{\infty }a_iv_i + f^{\perp }$$

f
=

∑

i
=
1

∞

a

i

v

i

+

f

⊥

be the orthogonal decomposition with descending |ai|. We prove that limτ→∞λτ,i = |ai|2. The continuous one-parameter semigroup
$$\{\mathcal {K}^s: s\geq 0\}$$

{

K

s

:
s
≥
0
}
is equivalent, almost surely, to the classical Koopman one-parameter semigroup defined on L2(X, ν), if the dynamical system is ergodic and has invariant measure ν on the phase space X.
Observation-Based Noise Calibration: An Efficient Dynamics for the Ensemble Kalman Filter
Authors: Dufée Benjamin , Mémin Etienne , Crisan Dan 
Published: December 2022

AbstractWe investigate the calibration of the stochastic noise in order to guide the realizations towards the observational data used for the assimilation. This is done in the context of the stochastic parametrization under Location Uncertainty (LU) and data assimilation. The new methodology is rigorously justified by the use of the Girsanov theorem, and yields significant improvements in the experiments carried out on the Surface Quasi Geostrophic (SQG) model, when applied to Ensemble Kalman filters. The particular test case studied here shows improvements of the peak MSE from 85% to 93%.
Coupling of Waves to Sea Surface Currents Via Horizontal Density Gradients
Authors: Holm Darryl D. , Hu Ruiao , Street Oliver D. 
Published: December 2022

AbstractThe mathematical models and numerical simulations reported here are motivated by satellite observations of horizontal gradients of sea surface temperature and salinity that are closely coordinated with the slowly varying envelope of the rapidly oscillating waves. This coordination of gradients of fluid material properties with wave envelopes tends to occur when strong horizontal buoyancy gradients are present. The nonlinear models of this coordinated movement presented here may provide future opportunities for the optimal design of satellite imagery that could simultaneously capture the dynamics of both waves and currents directly.The model derived here appears in two levels of approximation: first for rapidly oscillating waves, and then for their slowly varying envelope (SVE) approximation obtained by using the WKB approach. The WKB wave-current-buoyancy interaction model derived here for a free surface with significant horizontal buoyancy gradients indicates that the mechanism for the emergence of these correlations is the ponderomotive force of the slowly varying envelope of rapidly oscillating waves acting on the surface currents via the horizontal buoyancy gradient. In this model, the buoyancy gradient appears explicitly in the WKB wave momentum, which in turn generates density-weighted potential vorticity whenever the buoyancy gradient is not aligned with the wave-envelope gradient.
Critical Thinking – Gelegenheit für MINT-Lernen in der Zukunft?
Authors: Andersen Jasmin , Baum Michael , Dictus Christian , Greubel André , Knippertz Lynn , Krüger Johanna , Neumann Irene , Priemer Burkhard , Ruzika Stefan , Schulz Johannes , Siller Hans-Stefan , Tiemann Rüdiger 
Published: December 2022

ZusammenfassungDie moderne Welt ist gekennzeichnet durch eine fortschreitende Technologisierung und einen steten Wandel. Die damit einhergehenden Anforderungen lassen neue Fähigkeiten relevant werden. Diese häufig als 21st Century Skills bezeichneten Fähigkeiten umfassen unter anderem das sogenannte Critical Thinking. Der Begriff selbst entzieht sich dabei aber bisher einer einheitlichen und umfassenden Definition. Dieser Artikel verfolgt daher das Ziel, den Begriff Critical Thinking in seinen verschiedenen Facetten und Praxisausprägungen zu erläutern. Dafür werden zunächst Fähigkeiten und Fertigkeiten, die sich dem Critical Thinking zuordnen lassen, aus einer theoretischen Perspektive betrachtet, die Relevanz dieser Fähigkeiten in Bezug auf die MINT-Fächer herausgearbeitet und Querverbindungen zu verwandten Konzepten hergestellt. Ein anschließender Praxisteil illustriert an drei Beispielen, dass und wie Critical Thinking in konkrete Lernsituationen integriert werden kann. Insgesamt stellt dieser Beitrag damit ein Plädoyer dafür dar, Critical Thinking nicht als ein lästiges, auch noch zu beachtendes Unterrichtsziel zu verstehen, sondern vielmehr als einen integralen Bestandteil des MINT-Lernens der Zukunft.
Komplikationen der 180-W-XPS™-GreenLight-Laserung – Ergebnisse bei 1283 Prozeduren
Authors: Fallahi F. , Fallahi M. , Brauckmann R. , Brandt S. , Horstmann J. , Wiedemann A. 
Published: December 2022

Zusammenfassung
Hintergrund
Die vorliegende Untersuchung beschäftigt sich mit der Komplikationsrate des Verfahrens in einer neuen Methodik. Es wurden alle Patienten, die innerhalb von 3 Monaten nach ihrer 180-W-XPS™-GreenLight-Laserung (American Medical Systems, Minnetonka, MN, USA) (GLL) erneut stationär aufgenommen wurden, erfasst.

Methodik
Es konnten 170 Patienten ermittelt werden, welche nach ihrer 180-W-XPS™-GLL der Prostata innerhalb von 3 Monaten erneut stationär aufgenommen wurden. Alter, ASA-Score, Antikoagulation, der Umfang der 180-W-XPS™-GLL der Prostata (in Joule) und die Wiederaufnahmegründe in den Kategorien Hämaturie, Harnverhalt, Inkontinenz und Infektgeschehen wurden bei diesen Patienten analysiert und den Patienten ohne Wiederaufnahme gegenübergestellt.

Ergebnisse
Es ergab sich eine Wiederaufnahmequote von 13,25 %. Der Aufnahmegrund war am häufigsten ein Harnverhalt mit 50,6 % und eine Hämaturie mit 49,4 % aller Patienten. Von den Patienten mit einer auftretenden Hämaturie standen 86,75 % unter blutverdünnender Medikation.

Schlussfolgerung
Im Vergleich mit der Referenzzulassungsstudie („Goliath-Trial“), die 135 multizentrische Patienten umfasste, von welchen 14,07 % mindestens eine Grad-II-Komplikation nach Clavien-Dindo erlitten, zeigte sich eine vergleichbare Komplikationsrate. Dies ist umso erstaunlicher, da die mit der GLL in der vorliegenden Untersuchung behandelten Patienten sowohl im Alter als auch mit ihrer in der ASA-Klassifizierung (American Society of Anesthesiologists) ablesbaren Multimorbidität und damit nachfolgenden Polypharmazie Charakteristika geriatrischer Patienten aufweisen. Um Erfolge langfristig postoperativ für diese Patienten sicher stellen zu können, sollte die Verzahnung des ambulanten und stationären Sektors noch optimiert werden.
The antigen recognition portion of African buffalo class I MHC is highly polymorphic, consistent with a complex pathogen challenge environment, and the 3’ region suggests distinct haplotype configurations
Authors: Obara Isaiah , Nijhof Ard , Atimnedi Patrick , Mijele Domnic , Nanteza Anne , Elati Khawla , Bishop Richard 
Published: December 2022

AbstractAfrican buffalo (Syncerus caffer) have been distinct from the Auroch lineage leading to domestic cattle for 5 million years, and are reservoirs of multiple pathogens, that affect introduced domestic cattle. To date, there has been no analysis of the class I MHC locus in African buffalo. We present the first data on African buffalo class I MHC, which demonstrates that gene and predicted protein coding sequences are approximately 86–87% similar to that of African domestic cattle in the peptide binding region. The study also shows concordance in the distribution of codons with elevated posterior probabilities of positive selection in the buffalo class I MHC and known antigen binding sites in cattle. Overall, the diversity in buffalo class I sequences appears greater than that in cattle, perhaps related to a more complex pathogen challenge environment in Africa. However, application of NetMHCpan suggested broad clustering of peptide binding specificities between buffalo and cattle. Furthermore, in the case of at least 20 alleles, critical peptide-binding residues appear to be conserved with those of cattle, including at secondary anchor residues. Alleles with six different length transmembrane regions were detected. This preliminary analysis suggests that like cattle, but unlike most other mammals, African buffalo appears to exhibit configuration (haplotype) variation in which the loci are expressed in distinct combinations.
Gut microbiota is associated with response to 131I therapy in patients with papillary thyroid carcinoma
Authors: Zheng Lei , Zhang Linjing , Tang Li , Huang Dingde , Pan Deng , Guo Wei , He Song , Huang Yong , Chen Yu , Xiao Xu , Tang Bo , Chen Jing 
Published: December 2022

Abstract
Purpose
Radioactive iodine (131I) therapy is a conventional post-surgery treatment widely used for papillary thyroid carcinoma (PTC). Since 131I is orally administered, we hypothesize that it may affect gut microbiome. This study aims to investigate alterations of intestinal microbiome caused by 131I therapy in PTC patients and explore its association with response to 131I therapy.

Methods
Fecal samples of 60 PTC patients pre- and post-131I therapy were collected to characterize the 131I therapy-induced gut microbiota alterations using 16S rRNA gene sequencing. According to the inclusion criteria, sequence data of 40 out of the 60 patients, divided into excellent response (ER) group and non-excellent response (NER) group, were recruited to investigate the possible connection between gut microbiota and response to 131I therapy. Multivariate binary logistic regression was employed to construct a predictive model for response to 131I therapy.

Results
Microbial richness, diversity, and composition were tremendously altered by 131I therapy. A significant decline of Firmicutes to Bacteroides (F/B) ratio was observed post-131I therapy. 131I therapy also led to changes of gut microbiome-related metabolic pathways. Discrepancies in β diversity were found between ER and NER groups both pre- and post-131I therapy. Furthermore, a predictive model for response to 131I therapy with a p value of 0.003 and an overall percentage correct of 80.0% was established, with three variables including lymph node metastasis, relative abundance of g_Bifidobacterium and g_Dorea. Among them, g_Dorea was identified to be an in independent predictor of response to 131I therapy (p = 0.04).

Conclusion
For the first time, the present study demonstrates the gut microbial dysbiosis caused by 131I therapy in post-surgery PTC patients and reveals a previously undefined role of gut microbiome as predictor for 131I ablation response. G_Dorea and g_Bifidobacterium may be potential targets for clinical intervention to improve response to 131I in post-operative PTC patients.

Trial registration
ChiCTR2100048000. Registered 28 June 2021.
Bidemocratic Bases and Their Connections with Other Greedy-Type Bases
Authors: Albiac Fernando , Ansorena José L. , Berasategui Miguel , Berná Pablo M. , Lassalle Silvia 
Published: December 2022

AbstractIn nonlinear greedy approximation theory, bidemocratic bases have traditionally played the role of dualizing democratic, greedy, quasi-greedy, or almost greedy bases. In this article we shift the viewpoint and study them for their own sake, just as we would with any other kind of greedy-type bases. In particular we show that bidemocratic bases need not be quasi-greedy, despite the fact that they retain a strong unconditionality flavor which brings them very close to being quasi-greedy. Our constructive approach gives that for each $$1<p<\infty $$

1
<
p
<
∞

the space $$\ell _p$$

ℓ
p

has a bidemocratic basis which is not quasi-greedy. We also present a novel method for constructing conditional quasi-greedy bases which are bidemocratic, and provide a characterization of bidemocratic bases in terms of the new concepts of truncation quasi-greediness and partially democratic bases.