bluuebunny/crossref_metadata_2025_split huggingface dataset:
RT-based combination therapy for brain metastasis from NSCLC with non-EGFR mutation/ALK gene rearrangement: A network meta-analysis
Authors: Wu Min , Jiang Jun , Zhang Xuewen , Chen Jie , Chang Qiaomei , Chen Rong 
Published: November 2022

IntroductionRadiotherapy (RT) is currently the main treatment for brain metastases (BMs) from non-small cell lung cancer (NSCLC). Due to the short survival time and obvious adverse reactions of RT, we urgently need more appropriate treatment. This network meta-analysis reviewed the efficacy and adverse effects of radiotherapy-based combination therapy for patients without targeted epidermal growth factor receptor (EGFR) mutations/anaplastic lymphoma kinase (ALK) gene rearrangement NSCLC BMs, to screen out the therapy with the best efficacy.MethodsPubMed, Embase, Web of Science, and Cochrane Library were searched from the earliest publication date available to 1 April 2022. STATA15.0 was used to conduct heterogeneity analysis, sensitivity analysis, forest plot analysis, and publication bias analysis.ResultsA total of 28 studies, involving 3707 patients were included in the Bayesian network meta-analysis. In the limited paired meta-analysis for head-to-head comparative trials, compared with RT-based combination therapy, RT combined with Immune checkpoint inhibitors (ICIs) showed significant overall survival (OS) benefit (HR 0.65, 95%CI 0.47–0.9, p&lt;0.01), RT combined with ICIs showed a non-significant difference for intracranial progression-free survival (iPFS) (HR 0.76, 95%CI 0.27–2.27, p&lt;0.01) and progression-free survival (PFS) (HR 0.9, 95%CI 0.36–2.37, p&lt;0.01). In addition, according to the ranking results, compared with RT combined with chemotherapy(CT) or with targeted therapy(TT), RT combined with ICIs might be the best treatment mode for OS(ICIs+RT vs CT+RT vs TT+RT; 91.9% vs. 27.8% vs. 29.3%, iPFS (ICIs+RT vs CT+RT vs TT+RT, 46.9% vs 25.2% vs 25.6%) and PFS (ICIs+RT vs CT+RT vs TT+RT, 36.2% vs 31% vs 36.5%).ConclusionsRT combined with ICIs might be the best treatment mode to prolong the OS for BMs from NSCLC with non-EGFR mutation/ALK gene rearrangement.Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022350065, identifier (CRD42022350065)
A prediction model for the efficacy of continuous positive airway pressure on bronchiolitis
Authors: Shi Qingxia , Zhao Zhihua , Lin Jilei , Zhang Yin , Dai Jihong 
Published: November 2022

ObjectivesPrediction of the efficacy of continuous positive airway pressure (CPAP) on bronchiolitis is necessary for timely treatment. This study aims to establish a nomogram for efficacy of CPAP on bronchiolitis, and compares accuracy with Pediatric Risk of Mortality III (PRISM III), Brighton Pediatric Early Warning Score (Brighton PEWS) and Pediatric Critical Illness Score (PCIS).MethodsFrom February 2014 to December 2020, data on children diagnosed with bronchiolitis and treated with CPAP in Chongqing was collected. The nomogram was evaluated by using multivariate logistic regression analysis. We compared the predictive value of model with PRISM III, PEWS and PCIS.ResultsA total of 510 children were included. The nomogram prediction model including fever, APTT, white blood cells, serum potassium concentration, lactic acid, immunodeficiency, atelectasis, lung consolidation, congenital airway dysplasia and congenital heart disease was established. The AUC of the nomogram was 0.919 in the training set and 0.947 in the validating set. The model fitted well, as evidenced by the calibration curve and Hosmer-Lemeshow goodness-of-fit test. We discovered that the nomogram significantly performed better than PRISM III, PCIS and PEWS.ConclusionsA nomogram including ten factors for predicting the efficacy of CPAP on bronchiolitis was established. It had higher performance than the PRISM III, PCIS, and PEWS in terms of clinical benefits.
Effects of blood flow restriction training on anthropometric and blood lipids in overweight/obese adults: Meta-analysis
Authors: Sun Lei 
Published: November 2022

Abstract: Purpose: To systematically evaluate the effects of blood flow restriction training (BFRT) on anthropometric indicators and blood lipids in overweight/obese adults.Methods: A literature search was conducted on PubMed, Web of Science, Embase, Scopus, SPORTDiscus and Cochrane Library databases to determine the final literature based on inclusion and exclusion criteria. Review Manager 5.4.1 was used to evaluate the quality of the literature based on the Cochrane bias risk assessment tool, and Stata 17.0 software was used for Meta-analysis.Results: A total of 3,985 articles were screened, and five of the studies were included in the Meta-analysis, with a total 66 participants. In each study, subjects were measured before and after BFRT. Meta-results showed that BFRT significantly reduced BMI, lowered body weight, body fat % and waist circumference, significantly reduced total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) level, lowered triglycerides, and increased high-density lipoprotein cholesterol (HDL-C) level in overweight/obese adults.Conclusion: BFRT can be used as a safe and effective exercise prescription for personalized weight/fat loss. BFRT significantly reduces BMI by reducing body weight, body fat %, and waist circumference and has the effect of improving body composition. It also significantly reduced TC and LDL-C and tends to decrease TG and increase HDL-C in overweight/obese adults, potentially reducing the incidence of cardiovascular disease.
Drug resistance patterns and dynamics of tuberculosis in Zhejiang Province, China: Results from five periodic longitudinal surveys
Authors: Zhou Lin , Wu Beibei , Huang Fei , Liu Zhengwei , Wang Fei , Zhang Mingwu , Chen Bin , Chen Songhua , Wang Xiaomeng , Zhao Yanlin 
Published: November 2022

BackgroundAs one of the high multi-drug resistance tuberculosis countries, it is critical for China to understand patterns of drug resistance to better formulate effective treatment regimens.MethodsThe anti-TB Drug resistance surveillance has been conducted in Zheijang Province in years 1999, 2004, 2008, 2013, and 2018 respectively. We compared the prevalence of DR-TB from the latest survey with that of the previous four surveys in terms of all four first-line anti-TB drugs. We also examined the prevalence of rifampin-resistant TB (RR-TB) between the last two surveys and routine surveillance data.ResultsAmong 996 patients surveyed in 2018, the prevalence of RR-TB in new and previously treated TB cases was 2.5 and 4.3%, respectively. The prevalence of RR-TB among previously treated cases was much higher than for new cases in the four surveys from 1999 to 2013, while there was no significant difference between these groups in the 2018 survey. The percentage of TB cases resistant to fluoroquinolones in new patients was 3.8%. The prevalence of non-tuberculous mycobacteria increased over time; the prevalence of RR-TB among new cases slowly decreased. The prevalence of RR-TB in both new and previously treated TB cases from the latest two surveys was consistent with routine surveillance data.ConclusionsThis consistency between routine surveillance and periodic surveys for TB cases implies that with universal testing in Zhejiang Province, data from routine surveillance could be used instead of periodic surveys to improve access to timely and appropriate treatment for DR-TB. Levels of resistance were lower than whole-country and global estimates, further indicating the value of universal drug susceptibility testing.
Cognitive impairment assessed by Mini-Mental State Examination predicts all-cause and CVD mortality in Chinese older adults: A 10-year follow-up study
Authors: Li Zhiqiang , Gong Xinran , Wang Shengshu , Liu Miao , Liu Shaohua , Wang Yanding , Wu Di , Yang Meitao , Li Rongrong , Li Haowei , Li Xuehang , Chen Shimin , Zhang Xiushan , Jia Ruizhong , Guo Jinpeng , He Yao , Wang Yong 
Published: November 2022

ObjectiveCognitive impairment (CI) has been demonstrated as a useful proxy measure of mortality in Western populations. However, the predictive value of CI in Chinese populations is unknown. We aimed to explore whether CI is independently associated with increased long-term all-cause and cardiovascular disease (CVD) mortality in Chinese older adults and the association of performance in specific MMSE sub-domains to subsequent mortality.Methods and resultsA total of 4,499 older adults [mean (SD) age, 70.3(6.7) years] who received a sample investigation from 2011 to 2014 were followed up till 2021 for mortality. The Mini-Mental State Examination was used to assess cognitive function, and Cox's proportional hazard models were used to evaluate the effects of cognitive function on the risk of all-cause and CVD mortality. Demographic characteristics, lifestyle, and health status were included as covariates. During a 10-year follow-up, a total of 667 (14.8%) died. In the fully adjusted model, compared with cognitively normal participants with CI had a 1.33-fold [HR, 1.33; (95% CI, 1.10–1.61)] greater risk of all-cause mortality and a 1.45-fold [HR, 1.45; (95% CIs, 1.11–1.92)] greater risk of CVD mortality. After a similar multivariable adjustment, a per-SD increase in MMSE scores was associated with a reduced risk of all-cause mortality [HR, 0.85; (95% CI, 0.78–0.93)] and CVD mortality [HR, 0.74; (95% CI, 0.65–0.84)]. In the unadjusted model, MMSE sub-domains (apart from immediate recall) were associated with mortality. But only orientation and calculation and attention were still independently associated with all-cause and CVD mortality in a multivariable model.ConclusionThese findings confirmed that CI is a marker of all-cause and CVD mortality risk in Chinese older adults, independently of other commonly assessed risk factors, and some sub-domains of the MMSE may have stronger associations with mortality. Further research is needed to identify the mechanisms underlying the observed associations.
A new impact assessment model to integrate space debris within the life cycle assessment-based environmental footprint of space systems
Authors: Maury-Micolier Thibaut , Maury-Micolier Alice , Helias Arnaud , Sonnemann Guido , Loubet Philippe 
Published: November 2022

By analogy to conventional environmental impacts, the potential release of debris or generation of fragments can be considered as the emission of an environmental stressor damaging the orbital ‘natural’ resource which supports space activities. Hence, it appears relevant to integrate systematically the impact of the emission of debris on the orbital resource within the life cycle impact assessment (LCIA) step to broaden the scope of life cycle assessment (LCA) for space systems. The main objective of this article is to propose a set of characterization factors to compute the impact caused by the generation of debris within the orbital environment. To do so, the proposed approach follows the methodology of emission-related characterization models in LCIA. the characterization model enables to link the emission of debris and final economic damages to space activities through a complete impact pathway including the fate of debris in downstream orbital compartments, the exposure of targeted space objects to this debris, and the economic damage in case of collision between the debris and the space object. The model is computed for different compartments of the low earth orbit (LEO) region thanks to a discretization of the orbital environment. Results show that the potential damages are the highest for orbital compartments located in the orbital bands of altitude/inclination: 550–2000 km/52–54°, 1,200–2000 km/86–88°, 400–2000 km/96–100°, because of the downstream location of Starlink constellation, OneWeb constellation, and earth observation satellites, respectively. The proposed set of CFs can be used in the LCA of different space systems in order to include impacts and damages related to space debris, along with other environmental impacts. This original development fully in line with the standardized LCIA framework would have potential for further integration into harmonised sector-specific rules for the European space sector such as product environmental footprint category rules (PEFCR).
Textile electromyography electrodes reveal differences in lower limb muscle activation during loaded squats when comparing fixed and free barbell movement paths
Authors: Svensson Felicia , Aasa Ulrika , Strong Andrew 
Published: November 2022

IntroductionTraditional recordings of muscle activation often involve time-consuming application of surface electrodes affixed to the skin in laboratory environments. The development of textile electromyography (EMG) electrodes now allows fast and unobtrusive assessment of muscle activation in ecologically valid environments. In this study, textile EMG shorts were used to assess whether performing squats with the barbell resting freely on the shoulders or using a Smith machine for a fixed barbell movement path is preferable for maximizing lower limb muscle activation.MethodsSixteen athletes performed free and fixed barbell squats in a gym with external loads equivalent to their body mass. Quadriceps, hamstrings and gluteus maximus activation was measured bilaterally with textile EMG electrodes embedded in shorts.ResultsMean quadriceps activation was greater for the free compared with the fixed movement path for the right (mean difference [MD] 14μV, p = 0.04, ηp2 = 0.28) and left leg (MD 15μV, p = 0.01, ηp2 = 0.39) over the entire squat and specifically during the first half of the eccentric phase for the left leg (MD 7μV, p = 0.04, d = 0.56), second half of the eccentric phase for both legs (right leg MD 21μV, p = 0.05, d = 0.54; left leg MD 23μV, p = 0.04, d = 0.52) and the first half of the concentric phase for both legs (right leg MD 24μV, p = 0.04, d = 0.56; left leg MD 15μV, p = 0.01, d = 0.72). Greater hamstrings activation for the free path was seen for the second half of the eccentric phase (left leg MD 4μV, p = 0.03, d = 0.58) and first half of the concentric phase (right leg MD 5μV, p = 0.02, d = 0.72). No significant differences were found for gluteus maximus.DiscussionTextile EMG electrodes embedded in shorts revealed that to maximize thigh muscle activity during loaded squats, a free barbell movement path is preferable to a fixed barbell movement path.
Measuring the Evolution of Risk Communication Strategy for Health Authorities During the COVID-19 Pandemic: An Empirical Comparison Between China and the United States
Authors: Yuan Yue , Pang Na 
Published: November 2022

Objectives: Investigate how the speech context of news conferences reveals the risk communication strategies for health authorities during COVID-19 and measure the evolution of those risk communication strategies.Methods: We collected news conference transcripts concerning COVID-19 for the first quarter from the official websites of the Centers for Disease Control and Prevention (CDC) and the National Health Commission of the People’s Republic of China (NHC) in 2020. Quantitative analyses were conducted on the topics and emotions of transcripts to measure the evolution of risk communication strategy. A total of three types of analysis were carried out in our study: topic, sentiment, and risk communication evolution analyses.Results: The trending topics and the number of these in the two institutions evolved with the infection status. The CDC and NHC maintained primarily neutral sentiment, while the non-neutral sentiment of the CDC swung more dramatically. Furthermore, the changing pattern of risk communication evolution for the CDC and NHC varied, where the latter had a more stable change routine.Conclusion: Our study finds that the strategies could be measured by topic variation, emotional expressions, and confirmed cases. The CDC and NHC tend to adopt different risk communication strategies and have specific change routines facing the pandemic. In addition, our findings contribute to addressing the WHO research agenda for managing risk communication during the COVID-19 pandemic, which helps health authorities formulate and measure risk communication strategies.
concepção de enunciado na BNCC: possibilidades dialógicas
Authors: Pereira da Silva Maria Dnalda , Morais Xavier Manassés 
Published: November 2022

O presente artigo resulta de discussões desenvolvidas no Programa de Pós-Graduação em Linguagem e Ensino da Universidade Federal da Paraíba sobre a relação e a interação entre a Base Nacional Comum Curricular (BNCC) e as concepções dialógicas da linguagem que, a nosso ver, apresentam um diálogo possível, mesmo que o texto da Base não explicite a corrente teórica adotada. Nesse sentido, partimos do seguinte questionamento: como podemos pensar as orientações contidas na BNCC à luz da noção de enunciado expressa pelo Círculo de Bakhtin? No intuito de vislumbrarmos possíveis respostas, temos por objetivo: analisar como a noção de enunciado é abordada na BNCC do EM ao propor o trabalho com Língua Portuguesa. Assim sendo, a investigação se dará em duas frentes: a primeira, refletir sobre como a própria BNCC pode ser compreendida como enunciado; e a segunda como o documento aborda esse conceito, no que concerne ao ensino de Língua Portuguesa. Como base teórica, apoiamo-nos nas contribuições da Teoria Dialógica da Linguagem de Bakhtin e do Círculo. No que diz respeito à metodologia, trata-se de uma pesquisa documental, exploratória. Diante disso, os resultados apontam que ao propormos relações entre a BNCC e a abordagem dialógica da linguagem e, ao refletirmos sobre conceitos como linguagem, interação, diálogo e a própria noção de enunciado, é possível entender a BNCC como enunciado concreto, unidade real do discurso, um ato dialógico, que é, por natureza, social e historicamente situado.

PALAVRAS-CHAVE: BNCC. Enunciado. Comunicação discursiva
STRATEGI PENGEMBANGAN PARIWISATA: STUDI KASUS PANTAI BUNTU MATABING & PONNORI DI KABUPATEN LUWU
Authors: A. Tadda Muh. Rivaldi , Nurlinah Nurlinah , Sukri Sukri 
Published: November 2022

ABSTRACT
The purpose of this study is to explain how the strategy of the Department of Tourism and Culture in increasing local revenue and to determine the indicators of tourism development strategies. This type of research is qualitative. This study uses phenomenology and data collection techniques using instruments in the form of interviews, observations and document retrieval. The results showed that the Buntu Matabing and Ponnori beach tourism development strategy was not optimal, seen from 5 indicators: (1) HR, (2) Tourism promotion, and (3) Service facilities. Meanwhile indicators (4) Facilities and Infrastructure and (5) Environment are still not optimal due to inadequate facilities for amusement rides and roads, as well as an unsanitary environment.
Keywords: Tourism Development Strategy
ABSTRAK
Tujuan dari penelitian ini adalah untuk menjelaskan bagaimana strategi Dinas Pariwisata dan Kebudayaan dalam meningkatkan pendapatan asli daerah dan untuk mengetahui indikator strategi pengembangan pariwisata. Jenis penelitian adalah kualitatif. Penelitian ini menggunakan fenomenologis dan teknik pengumpulan data menggunakan instrumen berupa wawancara, observasi dan pengambilan dokumen. Hasil penelitian menunjukkan bahwa strategi pengembangan pariwisata pantai Buntu Matabing dan Ponnori ini belum maksimal, dilihat dari 5 indikator: (1) SDM, (2) Promosi kepariwisataan, dan (3) Fasilitas pelayanan. Sementara indikator (4) Sarana dan Prasarana dan (5) Lingkungan masih belum maksimal dikarenakan fasilitas wahana hiburan dan jalan yang masih belum memadai, serta lingkungan kurang bersih.
Kata Kunci: Strategi Pembangunan pariwisita
EFEKTIVITAS PELAYANAN PERIZIN USAHA PERDAGANGAN MELALUI PROGRAM PAPA JOSS DI KABUPATEN PADANG PARIAMAN
Authors: Yahya Afif Syarifudin , Amzan Arib Zhafran 
Published: November 2022

Tujuan dari penelitian ini adalah untuk mengetahui dan mendeskripsikan efektivitas dari Program PAPA JOSS dalam pelayanan Izin Usaha Perdagangan di Kabupaten Padang Pariaman. Metode yang digunakan dalam penelitian ini adalah penelitian deskriptif kualitatif dengan pendekatan induktif untuk menggambarkan objek penelitian berdasarkan fakta di lapangan. Teknik pengumpulan data dilaksanakan dengan cara observasi, wawancara, dan dokumentasi. Kemudian dianalisi melalui reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa Program PAPA JOSS di Kabupaten Padang Pariaman berdasarkan dari lima dimensi yang dikaji sudah berjalan secara efektif. Hal ini dapat dilihat dari meningkatnya jumlah masyarakat yang mengurus perizinan, meningkatnya indeks kepuasan masyarakat, dan masyarakat sangat terbantu karena tidak perlu menghabiskan uang dan tenaga untuk datang langsung ke kantor untuk pengurusan pelayanan perizinan usaha perdagangan.
PELATIHAN PENINGKATAN MOTIVASI BAGI PEGAWAI HARIAN LEPAS (PHL) DI BKPSDM PROVINSI KEPULAUAN BANGKA BELITUNG
Authors: Agustu Afendi  , Imam Rosadi  
Published: November 2022

Pegawai Harian Lepas (PHL) berfungsi untuk membantu dan mendukung pelaksanaan tugas PNS dalam bidang tertentu, guna kelancaran pekerjaan PNS seperti administrasi perkantoran, tenaga kebersihan, resepsionis dan tugas yang berkaitan dengan pelayanan publik yang merupakan fungsi dari Pemerintah Daerah. Untuk meningkatkan fungsi PHL tersebut dilakukan pelatihan peningkatan motivasi yang diikuti oleh 30 peserta, yang dilaksanakan selama 4 hari. Metode yang dilakukan adalah dengan ceramah (tatap muka), tanya jawab, story telling, simulasi, penayangan video dan game. Hasil pelatihan ini yakni tersampikannya materi yang dapat meningkatkan motivasi PHL, yakni dinamika kelompok, pengembangan potensi diri, etika publik, integritas, pelayanan prima, komitmen mutu, nasionalisme, manajemen perkantoran.