bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptome analysis reveals the prognostic and immune infiltration characteristics of glycolysis and hypoxia in head and neck squamous cell carcinoma
Authors: Liu Jun , Lu Jianjun , Li Wenli 
Published: March 2022

Abstract
Background
This study aims to construct a new prognostic gene signature in survival prediction and risk stratification for patients with Head and neck squamous cell carcinoma (HNSCC).

Method
The transcriptome profiling data and hallmark gene sets in the Molecular Signatures Database was used to explore the cancer hallmarks most relevant to the prognosis of HNSCC patients. Differential gene expression analysis, weighted gene co-expression network analysis, univariate COX regression analysis, random forest algorithm and multiple combinatorial screening were used to construct the prognostic gene signature. The predictive ability of gene signature was verified in the TCGA HNSCC cohort as the training set and the GEO HNSCC cohorts (GSE41613 and GSE42743) as the validation sets, respectively. Moreover, the correlations between risk scores and immune infiltration patterns, as well as risk scores and genomic changes were explored.

Results
A total of 3391 differentially expressed genes in HNSCC were screened. Glycolysis and hypoxia were screened as the main risk factors for OS in HNSCC. Using univariate Cox analysis, 97 prognostic candidates were identified (P < 0.05). Top 10 important genes were then screened out by random forest. Using multiple combinatorial screening, a combination with less genes and more significant P value was used to construct the prognostic gene signature (RNF144A, STC1, P4HA1, FMNL3, ANO1, BASP1, MME, PLEKHG2 and DKK1). Kaplan–Meier analysis showed that patients with higher risk scores had worse overall survival (p < 0.001). The ROC curve showed that the risk score had a good predictive efficiency (AUC > 0.66). Subsequently, the predictive ability of the risk score was verified in the validation sets. Moreover, the two-factor survival analysis combining the cancer hallmarks and risk scores suggested that HNSCC patients with the high hypoxia or glycolysis & high risk-score showed the worst prognosis. Besides, a nomogram based on the nine-gene signature was established for clinical practice. Furthermore, the risk score was significantly related to tumor immune infiltration profiles and genome changes.

Conclusion
This nine-gene signature associated with glycolysis and hypoxia can not only be used for prognosis prediction and risk stratification, but also may be a potential therapeutic target for patients with HNSCC.
From emotional intelligence to suicidality: a mediation analysis in patients with borderline personality disorder
Authors: Khosravi Mohsen , Hassani Fahimeh 
Published: March 2022

Abstract
Background
Borderline personality disorder (BPD) is a serious mental illness with a high suicidality rate between 40 and 85%. However, little is known concerning psychosocial risk and protective factors associated with suicidal behaviors in this clinical group. The main focus of the present study was on examining the relationship of emotional intelligence (EI) with suicidal behaviors and its mediators (e.g., depression, self-esteem, addiction potential, and disorder severity) among patients with BPD.

Methods
In this cross-sectional study, a total of 220 participants (including 110 patients with BPD and 110 healthy controls) in Zahedan, Iran, were examined using clinical interviewing and self-report measures of EI, suicidal behaviors, depression, self-esteem, addiction potential, and BPD symptom severity. The data were analyzed using SPSS v25.0 software at the significance level of p < 0.05.

Results
Our preliminary analysis showed higher levels of EI, depression, and self-esteem in the BPD group in comparison to healthy controls (p < 0.001). Furthermore, our findings showed that higher levels of addiction potential, BPD symptom severity, and depression and lower levels of self-esteem and EI were likely to be related to suicidal behaviors of the BPD group. Our results also supported the overall hypothesis that addiction potential, depression, BPD symptom severity, and self-esteem had a mediating role in the impact of EI on suicidal behaviors in the BPD group.

Conclusions
According to these findings, we have come to believe that training EI possibly plays a directly and/or indirectly potential preventive and therapeutic role in suicidal behaviors among patients with BPD. However, further longitudinal studies must be carried out to clarify the cause and effect relationship between EI, depression, self-esteem, addiction potential, BPD symptom severity, and suicidal behaviors.
Trend in age at menarche and its association with body weight, body mass index and non-communicable disease prevalence in Indonesia: evidence from the Indonesian Family Life Survey (IFLS)
Authors: Asrullah Muhammad , L’Hoir Monique , Feskens Edith J. M. , Melse-Boonstra Alida 
Published: March 2022

Abstract
Background
In western countries, age at menarche (AAM) is nowadays lower than a century ago, coinciding with increased Body Mass Index (BMI) and prevalence of non-communicable diseases (NCD). This study aimed to determine the time trend in AAM, and its association with BMI and NCD prevalence at later age, in Indonesia.

Methods
We used secondary data of 15,744 women aged 15–65 years from the Indonesian Family Life Survey (IFLS) conducted in the period 1993 to 2015. Multiple linear regression was applied to determine the association of AAM with BMI, and Poisson regression with robust variance for investigating the association of AAM with NCD prevalence ratios. Models were adjusted for age, and effect modification by wealth status, living area, and region was investigated.

Results
AAM has significantly declined from 14.4 (SD:2.1) years of age in the 1940s to 13.4 y (SD:1.5) in the 1990s. AAM was inversely associated with BMI (β: − 0.30 kg/m2, 95%CI: − 0.37, − 0.22) and body weight (β: − 0.67 kg, 95%CI: − 0.75, − 0.54), but was not associated with height. After adjustment for age, AAM was not associated with NCD, i.e. hypertension, type 2 diabetes mellitus, liver diseases, asthma, chronic lung diseases, cardiovascular diseases, stroke, cancer, or arthritis. Including BMI in the models did not change the results.

Conclusions
From the 1940s to 1990s, AAM has declined with 1 year in Indonesia. Women with earlier AAM had higher BMI and body weight at later age, but AAM was not associated with NCD prevalence in later life in the Indonesian population. Further longitudinal research is needed to disentangle the direction of causality of the associations.
Analysis of relationship between loading condition and cranial cracking pattern using a three-dimensional finite element model
Authors: Kiriyama Yoshimori , Sato Yudai , Muramatsu Yota , Mano Teppei , Tanaka Katsumasa , Oshio Kotaro 
Published: March 2022

Abstract
Background
A hairline crack on the cranium can occur even under a small external load or impact and are thus often observed in patients who have experienced an accidental fall or collision. Typical finite element analysis is useful to analyze the stress concentration or the propagation of stress waves. However, a stress propagation model does not accurately reproduce the features of hairline cracks on the cranium. The objective in this study was to reproduce cranial hairline cracks.

Methods
A three-dimensional finite element model of the cranial bone was developed from a patient CT images. The model consists of the frontal, parietal, occipital and temporal bones, and the bones are connected with the sutures. Additionally, the model comprised three layers; the external and internal tables and the diploe. The model was analyzed using the extended finite element method (X-FEM), and a forming limit diagram (FLD) was embedded in the model. In this study, the model was symmetrized bilaterally using the model developed from the left side of the skull. The FLD in this study was assumed to be a relationship between the maximum and minimum strains when a fracture occurs. A total of 13 typical loadings were applied to the model: loading points on the top, left, and back of the cranium were considered, and at each loading point, loads were applied with four or five different directions, namely perpendicular to the cranium and inclined in the anterior, posterior, superior, or inferior at an angle of 45∘.

Results
Under all loading conditions, many small cracks formed radially at the loading points. Moreover, some large cracks formed under the certain loading conditions. The crack shapes on the top and left side could be associated with the specific loading directions, whereas cracks on the back did not show distinguishing characteristics depending on the loading directions. The present model was reproduced anatomically and morphologically, and the results were similar to those obtained in previous cadaver experiments.

Conclusions
Through X-FEM analysis of the FE model embedded with an FLD, hairline cracks in the cranium were reproduced, and a few crack shapes were identified as potential markers for estimating the loading conditions.
Progress in germline stem cell transplantation in mammals and the potential usage
Authors: Zhang Wen , Nie Ruotian , Cai Yihui , Xie Wenhai , Zou Kang 
Published: March 2022

AbstractGermline stem cells (GSCs) are germ cells with the capacities of self-renewal and differentiation into functional gametes, and are able to migrate to their niche and reconstitute the fertility of recipients after transplantation. Therefore, GSCs transplantation is a promising technique for fertility recovery in the clinic, protection of rare animals and livestock breeding. Though this novel technique faces tremendous challenges, numerous achievements have been made after several decades’ endeavor. This review summarizes the current knowledge of GSCs transplantation and its utilization in mammals, and discusses the application prospect in reproductive medicine and animal science.
A choice experiment assessment of stated early response to COVID-19 vaccines in the USA
Authors: Daziano Ricardo A. 
Published: March 2022

Abstract
Background
Using choice microdata (N=2723) across the USA, this paper analyzes elicited acceptance of hypothetical COVID-19 vaccines.

Methods
The hypothetical vaccines in a choice experiment were described in terms of effectiveness, days for antibodies to develop, duration of protection, risk of both mild and severe side effects, which health agency mainly supports the vaccine, country of origin, and when the vaccine was developed. Out-of-pocket cost was also considered as characteristic of the vaccines to derive welfare measures.

Results
All vaccine attributes had expected signs with significant estimates. Vaccines developed in the USA and the UK were preferred to a hypothetical German vaccine, whereas a Chinese origin was very negatively perceived. Since the choice scenarios also gave the option to opt out from taking the vaccine, odds ratios were derived to characterize the segments that are more and less likely to accept vaccination. More likely to opt out were found to be those who stated to be against vaccination in general, African Americans, individuals without health insurance, and older people. Males, democrats, those who took the flu vaccine appear as more willing to accept vaccination.

Conclusions
Estimates of the fitted choice models in this study are informative for current and future immunization programs.
Digital self-management interventions for osteoarthritis: a systematic scoping review of intervention characteristics, adherence and attrition
Authors: Patten Rhiannon K. , Tacey Alexander , Pile Rebecca , Parker Alexandra , De Gori Mary , Tran Phong , McKenna Michael J. , Lane Rebecca , Apostolopoulos Vasso , Said Catherine M. , Levinger Itamar , Woessner Mary N. 
Published: March 2022

Abstract
Background
Osteoarthritis (OA) is a chronic, progressive condition that can be effectively managed via conservative treatments including exercise, weight management and education. Offering these treatments contemporaneously and digitally may increase adherence and engagement due to the flexibility and cost-effectiveness of digital program delivery. The objective of this review was to summarise the characteristics of current digital self-management interventions for individuals with OA and synthesise adherence and attrition outcomes.

Methods
Electronic databases were searched for randomised controlled trials utilising digital self-management interventions in individuals with OA. Two reviewers independently screened the search results and extracted data relating to study characteristics, intervention characteristics, and adherence and dropout rates.

Results
Eleven studies were included in this review. Intervention length ranged from 6 weeks to 9 months. All interventions were designed for individuals with OA and mostwere multi-component and were constructed around physical activity. The reporting of intervention adherence varied greatly between studies and limited the ability to form conclusions regarding the impact of intervention characteristics. However, of the seven studies that quantified adherence, six reported adherence > 70%. Seven of the included studies reported attrition rates < 20%, with contact and support from researchers not appearing to influence adherence or attrition.

Conclusions
Holistic digital interventions designed for a targeted condition are a promising approach for promoting high adherence and reducing attrition. Future studies should explore how adherence of digital interventions compares to face-to-face interventions and determine potential influencers of adherence.
Telecommunications, productivity and regional dependence: a comparative analysis between the Brazil, China and main developed regions in the post-reform period
Authors: Betarelli Admir Antonio , Faria Weslem Rodrigues , Montenegro Rosa Livia Gonçalves , Perobelli Fernando Salgueiro , de Santana Ribeiro Luiz Carlos 
Published: March 2022

AbstractIn the last two decades, new technologies and the rapid growth of the telecommunications sector have changed production and trade relations in world economic systems. Regional dependence on the level of productivity, supply and demand of telecommunications has increased worldwide. Our study analyzes the changes in total factor productivity (TFP) of telecommunications and verifies its global and regional importance between 2000 and 2014. We apply the TFP decomposition and extraction technique in an input−output model. The main findings suggest improved efficiency has resulted in TFP gains in developed countries, whose variations were lower than those of Brazilian telecommunications, which exhibit a low capital—labor ratio. Moreover, global and regional dependence is more sensitive to supply than the demand for telecommunications. Although the main effects on the regional output are intraregional, the backward and forward effects denote a heavy regional reliance on USA telecommunications and reciprocity between China and European countries. The increase in telecommunications influenced by national policies in countries with little emphasis on regional composition should generate minor marginal gains in TFP, even with the gain in productive efficiency. These policies are also expected to reduce the dependence on American and Chinese telecommunications.
The ICD-11 classification of personality disorders: a European perspective on challenges and opportunities
Authors: Bach Bo , Kramer Ueli , Doering Stephan , di Giacomo Ester , Hutsebaut Joost , Kaera Andres , De Panfilis Chiara , Schmahl Christian , Swales Michaela , Taubner Svenja , Renneberg Babette 
Published: March 2022

AbstractThe 11th revision of the World Health Organization (WHO) International Classification of Diseases (ICD-11) includes a fundamentally new approach to Personality Disorders (PD). ICD-11 is expected to be implemented first in European countries before other WHO member states. The present paper provides an overview of this new ICD-11 model including PD severity classification, trait domain specifiers, and the additional borderline pattern specifier. We discuss the perceived challenges and opportunities of using the ICD-11 approach with particular focus on its continuity and discontinuity with familiar PD categories such as avoidant PD and narcissistic PD. The advent of the ICD-11 PD classification involves major changes for health care workers, researchers, administrators, and service providers as well as patients and families involved. The anticipated challenges and opportunities are put forward in terms of specific unanswered questions. It is our hope that these questions will stimulate further research and discussion among researchers and clinicians in the coming years.
Hyperthermic Intraperitoneal Chemotherapy–Induced Molecular Changes in Humans Validate Preclinical Data in Ovarian Cancer
Authors: Dellinger Thanh H. , Han Ernest S. , Raoof Mustafa , Lee Byrne , Wu Xiwei , Cho Hyejin , He Ting-Fang , Lee Peter , Razavi Marianne , Liang Winnie S. , Schmolze Daniel , Priceman Saul J. , Lee Stephen , Lin Wei-Chien , Lin Jeff F. , Kebria Mehdi , Hakim Amy , Ruel Nora , Stewart Daphne B. , Wang Edward W. , Paz Benjamin I. , Wakabayashi Mark T. , Cristea Mihaela C. , Rodriguez-Rodriguez Lorna 
Published: March 2022

PURPOSE Hyperthermic intraperitoneal chemotherapy (HIPEC) confers a survival benefit in epithelial ovarian cancer (EOC) and in preclinical models. However, the molecular changes induced by HIPEC have not been corroborated in humans. PATIENTS AND METHODS A feasibility trial evaluated clinical and safety outcomes of HIPEC with cisplatin during optimal cytoreductive surgery (CRS) in patients with EOC diagnosed with stage III, IV, or recurrent EOC. Pre- and post-HIPEC biopsies were comprehensively profiled with genomic and transcriptomic sequencing to identify mutational and RNAseq signatures correlating with response; the tumor microenvironment was profiled to identify potential immune biomarkers; and transcriptional signatures of tumors and normal samples before and after HIPEC were compared to investigate HIPEC-induced acute transcriptional changes. RESULTS Thirty-five patients had HIPEC at the time of optimal CRS; all patients had optimal CRS. The median progression-free survival (PFS) was 24.7 months for primary patients and 22.4 for recurrent patients. There were no grade 4 or 5 adverse events. Anemia was the most common grade 3 adverse event (43%). Hierarchical cluster analyses identified distinct transcriptomic signatures of good versus poor responders to HIPEC correlating with a PFS of 29.9 versus 7.3 months, respectively. Among good responders, significant HIPEC-induced molecular changes included immune pathway upregulation and DNA repair pathway downregulation. Within cancer islands, % programmed cell death protein 1 expression in CD8+ T cells significantly increased after HIPEC. An exceptional responder (PFS 58 months) demonstrated the highest programmed cell death protein 1 increase. Heat shock proteins comprised the top differentially upregulated genes in HIPEC-treated tumors. CONCLUSION Distinct transcriptomic signatures identify responders to HIPEC, and preclinical model findings are confirmed for the first time in a human cohort.
Perspectives and Experiences of Parents and Adolescents Who Participate in a Pediatric Precision Oncology Program: "When You Feel Helpless, This Kind of Thing Is Very Helpful"
Authors: Waldman Larissa , Hancock Kelly , Gallinger Bailey , Johnstone Brittney , Brunga Ledia , Malkin David , Barrera Maru , Villani Anita 
Published: March 2022

PURPOSEThe SickKids Cancer Sequencing (KiCS) Program, launched in 2016, evaluates the clinical utility of paired tumor/germline Next-Generation Sequencing (NGS) in pediatric oncology patients with hard-to-cure and rare cancers. In anticipation of further widespread adoption of NGS, we aimed to characterize the experiences and perspectives of adolescents and parents of patients who have already undergone NGS evaluation, focusing on the psychosocial impact and personal utility.METHODSParents of patients with pediatric cancer and adolescent patients who have participated in KiCS were invited to participate in semistructured interviews. Transcripts were analyzed using an inductive content analytic approach.RESULTSOf 45 individuals invited, 22 parents and 10 adolescents were interviewed (71% response rate). Prominent psychosocial themes were low distress, relief, and sense of control; some expressed fear of the unknown. In exploring constructs of personal utility, parents highlighted hope for treatment options despite low expectations for results with clinical impact, whereas adolescents articulated altruistic motivations and less hope for personal clinical benefit. Bringing closure and answering the question of why the cancer occurred was a salient theme among both groups. Both parents and adolescents find benefit and clear decisional satisfaction with participation. No participants expressed regret.CONCLUSIONThis study suggests that parents and adolescents benefit from NGS evaluation beyond the return of clinically relevant results. Our findings lay the framework for future work evaluating the value of NGS in pediatric precision oncology care through assessment of patient-reported outcomes and experiences. These results also guide provision of pre- and post-test education and support, which will facilitate patient-centered delivery of NGS practices.
Infografika. Multimodalny przekaźnik informacji w środowisku akademickim
Authors: Sierak Katarzyna 
Published: March 2022

Infografiki stają się coraz popularniejsze. Korzyści płynące z ich stosowania dostrzegane są także w środowisku akademickim. Nauczyciele akademiccy chętnie sięgają po infografiki na platformie społecznościowej, jaką jest Facebook, przede wszystkim po to, aby komunikować się ze swoimi studentami w sprawach bieżących, ale także aby zachęcić do studiowania potencjalnych kandydatów. Takie wyjście naprzeciw panującym trendom wydaje się uzasadnione, ponieważ młodzież obecnie studiująca, wychowana w czasach cyfryzacji i przełomu technologicznego, poszukuje i oczekuje informacji przekazywanej w znany sobie sposób, tj. przede wszystkim za pośrednictwem sieci Internet. Celem niniejszego artykułu jest ukazanie, w jaki sposób kadra akademicka Wydziału Humanistycznego Uniwersytetu Warmińsko-Mazurskiego w Olsztynie komunikuje się ze swoimi studentami lub/i potencjalnymi kandydatami za pomocą infografik oraz jakie cele im w tym przyświecają.
How Return on Investment and Residual Income Performance Measures and Risk Preferences Affect Risk-Taking
Authors: Brown Jason L. , Martin Patrick R. , Sprinkle Geoffrey B. , Way Dan 
Published: March 2022

Return on investment (ROI) and residual income (RI) are two important accounting measures that are commonly used to evaluate managers’ performance, and evidence suggests that both ROI and RI can help motivate long-term investments. Research is limited, though, regarding whether ROI and RI differentially affect managers’ actions, and, more specifically, research has not examined the effects of ROI and RI on risk-taking. We conduct an experiment to examine the separate and interactive effects of individuals’ risk preferences and ROI and RI performance measures on risk-taking in capital investment decisions. We predict and find that the use of ROI as a performance measure leads to riskier choices, as compared with RI, and that this effect is concentrated in relatively more risk-averse individuals. We also provide process evidence that reveals some of the ways in which ROI and RI performance measures affect decision making. Collectively, our results contribute to literature examining the effects of accounting information and performance measures on managers’ risk-taking behaviors. This paper was accepted by Suraj Srinivasan, accounting. Funding: Financial support from the Kelley School of Business at Indiana University is gratefully acknowledged. Supplemental Material: Data files are available at https://doi.org/mnsc.2022.4398 .