bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of Seasonal Variation of Indoor Radon-222 Concentration
Authors: Belete Guadie Degu , Shiferaw Aragaw Msganaw 
Published: April 2022

Abstract
Inhalation and ingestion are the two main routes upon which human beings are exposed to radon and its decay products. Due to the electrostatics nature, radon can attach to solid particles and aerosols in the surrounding air. During the inhalation of these radioactive aerosols deposition will be takes place in different regions of the human respiratory tract. The deposited aerosols carrying radon and its progeny undergo a continuous radioactive transformation and exposing the lung to the ionizing alpha radiation which can destroy sensitive cells in the lung causing a mutation that turns to cancerous. Radon which is colorless, odorless and tasteless radioactive noble gas is the major health concern which is the second leading cause of lung cancer. In this concern, indoor radon survey has been conducted in many countries in the world. The result of these surveys shows that indoor radon concentration has a seasonal variation. This is due to the fluctuation of environmental parameters and geological nature of the building. Its concentration was found maximum in cool (winter) season and minimum concentration was recorded in warm (summer) season of the year.
Improvement in texture and color of soy protein isolate gel containing capsorubin and carotenoid emulsions following microwave heating
Authors: Wang Shengnan , Li Yangyang , Liu Xiulin , Zhao Guilan , Yang Lina , Zhu Lijie , Liu He 
Published: April 2022

Abstract
The effects of capsorubin and carotenoid emulsions on the properties of soybean protein isolate (SPI) gels were studied following microwave heating. The data confirmed that emulsions have a protective effect on the capsorubin and carotenoid. Rheological properties and the texture of SPI gels were investigated. All SPI gels showed shear–thinning behavior, and the viscosity, G′ and G″ of SPI gels containing capsorubin and carotenoid emulsions was significantly higher than gels with added pigment aqueous solution. These results illustrate that the SPI gels containing emulsions tend to form a gel–like structure and were in a state of elastic dominance. In addition, differential scanning calorimetry (DSC), fourier transform infrared (FTIR) spectroscopy and scanning electron microscope (SEM) methods were used to investigate the interaction between SPI and soybean soluble polysaccharide (SSPS) in the gels structure, confirming that the SPI gels have a more continuous, folded and uniformly dense three–dimensional network structure. Most importantly, the chain entanglements between proteins and polysaccharides became even tighter due to microwave heating. The overall results suggested that the emulsion had an excellent protective effect on the capsorubin and carotenoid and was beneficial to the application of pigments in food and supplements.
Anterior mediastinal seminoma with myasthenia gravis: A rare case report and literature review
Authors: WEN YEN-CHANG , HSIA JIUN-YI , KE TUAN-YING , HSU JENG-DONG 
Published: April 2022

Abstract
Background:Myasthenia gravis may be associated with thymic follicular hyperplasia or thymomas. We present a case of an anterior mediastinal tumor with myasthenia gravis, which turned out to be seminoma. We also review the literature on seminoma with myasthenia gravis in this article.Case presentation:A 34-year-old man presented to our hospital with a complaint of diplopia. Single fiber electromyography revealed ocular myasthenia gravis; chest computed tomography showed a 1.5 cm anterior mediastinum nodule suspected as thymoma. The patient underwent video-assisted thoracoscopic thymectomy. Histopathological findings revealed seminoma with thymic follicular hyperplasia.Conclusion:Anterior mediastinal seminoma with thymic follicular hyperplasia is rare and extremely rare with associated myasthenia gravis. Though rare, young male patient with anterior mediastinal tumor and myasthenia gravis, thymic seminoma is one possible cause. Testicular examination can be taken into consideration before operation.
Cytokines in cerebrospinal fluid and serum as biomarkers are associated with the diagnosis and efficacy evaluation of neurosyphilis
Authors: Zhang Xiao Ying , Gesang Meiduo , Wu Sha , Chen Jie Fang , Wang Zheng , Chi Shu Mei , Jin Man , Song Ming Fen , Wang Shu Qi 
Published: April 2022

Abstract
Background
Neurosyphilis remains a chronic infectious disease within central nervous system infected by Treponema pallidum (TP). At present, the diagnosis and efficacy evaluation of neurosyphilis still facing clinical challenges. It has been reported that cytokines, which play multiple roles in neuroinflammation, showed abnormal expression patterns in neurosyphilis. To search for potential biomarkers of neurosyphilis, we analyzed the changes of cytokine profiles in cerebrospinal fluid (CSF) and serum of neurosyphilis. This may provide insight into clinical values for neurosyphilis.
Methods
Using the quantitative antibody array platform, we measured 80 cytokines expression in the CSF and serum of 16 subjects. 9 patients diagnosed with neurosyphilis, included samples before and after antibiotic treatment. 7 patients with non-inflammatory neurological diseases (NIND) were used as controls. Compared to the differences in cytokine expression between groups and analyzed to the correlations between cytokines and clinical CSF parameters. The ability of valuable biomarkers to diagnosis of neurosyphilis was evaluated by receiver operating characteristic (ROC) curves.
Results
We observed significantly increased of multiple cytokines (26/80) in CSF of neurosyphilis were significantly increased compared to the NIND group. Concentrations of 15 cytokines were significantly decreased after treatment, of which 11 cytokines were down regulated to the levels were similar to the NIND group. Most CSF cytokine concentrations consistently correlated with clinical parameters, positively related to white blood cells (WBCs, 42/80), total protein (36/80), and albumin quotient (Qalb, 37/80) and negatively related to Glucose level (22/80). More than 40 cytokines concentrations correlated with each other in CSF, most of them were positively correlated. But correlations between CSF cytokine and serum cytokine values were scarce (6/80). The area under the ROC curve (AUC) of G-CSF, ICAM-1, CCL4, CCL19 and IL-12p40 in CSF were all greater than 0.9, with high diagnostic values.
Conclusions
Our data showed that multiple CSF cytokines were highly expressed of neurosyphilis, and their levels were significantly reduced after antibiotic treatment. Meanwhile, these cytokines were significantly correlated with various CSF parameters. The AUCs of G-CSF, ICAM-1, CCL4, CCL19 and IL-12p40 were all greater than 0.9, suggesting that these cytokines may serve as potential biomarkers for neurosyphilis. Unfortunately, more meaningful results were not observed in the analysis at the serum level. Therefore, along with previous related reports, it is believed that CSF measures are irreplaceable in the current clinical diagnosis, and the combined dynamic detection of multiple cytokines such as G-CSF, ICAM-1, CCL4, CCL19 and IL-12p40 in CSF can serve as a supplementary diagnostic tool for neurosyphilis.
Co/Ni/Al-LTH layered triple hydroxides with zeolitic imidazolate frameworks (ZIF-8) as high efficient removal of diazinon from aqueous solution
Authors: Samadi-Maybodi Abdolraouf , Ghezel-Sofla Hashem 
Published: April 2022

Abstract
Today, high consumption and increasing use of pesticides and chemical fertilizers to control pests of agricultural products, and the entry of these pollutants into the environment, is one of the most important environmental and health problems. Their non-biodegradability, as well as their toxicity and carcinogenicity, have generally made these compounds one of the most dangerous pollutants that cause inevitable pollution of the environmental.Among the various methods used to remove agricultural pesticide residues from the water sources, the adsorption method has received more attention due to its simplicity, cost and higher efficiency.In this research, nanocomposite of Co/Ni/Al-LTH@ZIF-8 was synthesized by in-situ growth of ZIF-8 on the Co/Ni/Al-LTH and used for the removal of diazinon pesticide from aqueous solution. Characterizations of the nanocomposite were performed by various techniques, including Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, energy dispersive X-ray spectroscopy and thermal analysis. Statistical evaluation was studied by BOX-Behnken design. In addition, the response surface methodology was used to optimize the factors affecting on the adsorption process. Parameters such as adsorbent dose (mg), pH, and contact time (min) were considered in this experiment. Results revealed that the removal efficiency of diazinon was significantly improve (from 64% to 84%) by loading ZIF-8 on the Co/Ni/Al-LTH. Statistical studies showed the optimum conditions achieved under pH=6.9, adsorbent dosage 25 mg, and contact time 12 min.
Identification and comparison of two risk models based on characteristic gene sets of breast cancer for predictive prognosis
Authors: Ma Chaoqun , Yu Ying , Chen Jiaying , Yao Chang , Bian Weihe , Wang Cong , Ye Bei , Shen Tong , Guo Mengmeng , Zhang Xiping , Cao Shihan 
Published: April 2022

Abstract
Background: Breast cancer (BC) is one of the main causes of cancer related deaths in women, and also has a high mortality rate in men, resulting in great healthy problems worldwide. Because of its low cure rate, poor late prognosis, and high mortality, it is of great significance to find new biomarkers for diagnosis and prognosis.Methods: In this study, 1030 cases of BCs from The Cancer Genome Atlas (TCGA) were obtained for differential expression analysis and short time-series expression miner (STEM) analysis to identify the BC development characteristic genes, divided into up-regulated genes and down-regulated genes with the development of BC. Two predictive prognosis models were both defined by Lasso. Survival analysis and ROC curve analysis were used respectively to determine the diagnostic and prognostic abilities of the two gene set models scores. Univariate and multivariate Cox regression analyses were used to determine whether the risk models are independent prognostic indicators and whether our models are better than the present clinicopathological features in prognosis.Results: Our findings from this study suggest both the breast cancer unfavorable (BC1) and the breast cancer favorable (BC2) gene sets are reliable biomarkers for the diagnosis and independent biomarkers for predictive prognosis of BC, while BC1 model presents better diagnostic and prognostic value than BC2 model. Associations between the models and macrophages M2, the sensitivity to Bortezomib were also found, implying that the BC unfavorable genes are significantly involved in the tumor immune microenvironment of BC.Conclusion: In conclusion, we successfully established two predictive prognosis models based on characteristic gene sets of BC, and one prognosis model (BC1) to diagnosis and predict the survival time of BC patients using a cluster of 12 DEGs. Additionally, the high infiltration of macrophages M2 and high sensitivity to Bortezomib in high risk group scored by our risk models provided theoretical support for further basic and clinical research on the tumor immune microenvironment of BC.
Evaluation of Serum Vegf - A and Interleukin 6 as Predictors of Angiogenesis During Peri-Implantation Period Assessed by Transvaginal Doppler Ultrasonography Amongst Women of Prior Reproductive Failure.
Authors: Nair Priya , Shrivastava Deepti 
Published: April 2022

Abstract
BACKGROUND
Infertility is a wide spectrum of disorder affecting many couples and is defined as the inability of a couple to achieve pregnancy. A series of investigations are required to know the reason behind infertility, yet a small percentage (08–37%) of couples exist, in which no obvious cause is delineated. Infertility causes enormous emotional, physiological, psychological, sexual, social and financial burden on family. Different hormones, growth factors and interleukins are responsible for successful ovulation, implantation and further growth of embryo. Endometrial receptivity is an important predictor of the outcome of implantation and further growth of embryo.
METHOD
The study would be conducted in a tertiary care centre over a period of two years from July 2022 till July 2024 on non-pregnant unexplained infertile women (63) who will undergo In Vitro Fertilisation and Embryo Transfer (IVF-ET) in the following cycle and the result will be compared with the fertile women (21) with same demographic features. The levels of serum Vascular Endothelial Growth factor – A, Interleukin- 6 will be measured on day 21 of the menstrual cycle in both the group, simultaneously, transvaginal ultrasonography and doppler findings will be measured in both groups to see for endometrial receptivity. The values will be compared for any significance.
RESULTS
The values of Serum VEGF-a, IL6 and Doppler findings will be compared between fertile and infertile group to see for significance difference. The main reason behind doing research on this topic is to find a more cost effective, non-invasive and less time-consuming technique to find Endometrial Receptivity as compared to invasive Endometrial Receptivity Analysis (ERA) Technique. Also, a new scoring system will be developed considering these 3 parameters of endometrial receptivity (PREDICGIO scoring system) for better analysis of endometrial receptivity and to determine the method to be used in patients of infertility for getting pregnancy without much financial burden.
Fear of cancer recurrence and hope level in patients receiving surgery for non-small cell lung cancer : A study on the mediation role of social support
Authors: Liu Yan , Liu Man , Liu Lu , Zhang Shuoning , Li Ting , Ma Fengyan 
Published: April 2022

Abstract
Purpose: To study the level of fear of cancer recurrence (FCR) in patients receiving surgery for non-small cell lung cancer (NSCLC) and explore related factors, so as to improve the hope level in this population, help enhance the confidence to defeat the disease and thereby increase the quality of life.Methods: A total of 327 postoperative NSCLC patients from the National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College were enrolled. All participants filled in General Questionnaire, Fear of Progression Questionnaire-Short Form (FoP-Q-SF), Herth Hope Index (HHI) Scale, and Social Support Rating Scale (SSRS). Results: The mean FoP-Q-SF score was (30.3 ± 9.48) points in postoperative NSCLC patients, and that ≥ 34 points was reported by 188 patients (57.5%). Patient gender and family income were independent risk factors for FCR (both p<0.05). Correlation analysis revealed a negative association between FCR and hope level (p<0.05) while a positive association between hope level and social support (p<0.05). Notably, the social support played a mediation role between FCR and hope level in patients receiving surgery for NSCLC (contribution effect: 30.24%). Conclusion: Postoperative NSCLC patients experience a moderate-level of FCR, especially the females and those with a low family income. Social support plays a partial mediation role between the FCR and hope level in this population. In that way, increase in the level of social support can elevate the hope level in patients, thereby decreasing the level of FCR and advancing recovery.
HMGB1 recruits NK cells by CXCL12/CXCR4 axis contributing to persistent airway inﬂammation and AHR during the later stage of RSV infection
Authors: Chen Sisi , Tang Wei , Yu Guangyuan , Liu Enmei 
Published: April 2022

Abstract
Our previous studies have shown that both high-mobility group box-1 (HMGB1) and natural killer cells (NK cells) contribute to respiratory syncytial virus (RSV) induced persistent airway inflammation and airway hyperresponsiveness (AHR). Meanwhile, Chemokine (C-X-C motif) ligand 12 (CXCL12) and its receptor chemokine receptor 4 (CXCR4) were reported to play important roles in recruitment of immune cells. The relationships between them were unclear. We investigated whether HMGB1 can recruit NK cells by CXCL12/CXCR4 axis, thereby mediating RSV induced persistent airway disorders. Anti-HMGB1 neutralizing antibody and inhibitor of CXCR4 (AMD3100) were administered to observe the change of the percentage of NK cells and the airway disorders in nude mice. In the study, we found that mRNA and protein expression of HMGB1 were elevated in the later stage of RSV infection and persistent airway inflammation and AHR were diminished after administration of anti-HMGB1 antibodies with NK cells decreased significantly. At the same time, CXCL12 and CXCR4 were reduced after HMGB1 blockade. Treatment with AMD3100 was found to significantly suppress the recruitment of NK cells and alleviate the airway disorders. Therefore, HMGB1 recruits NK cells by CXCL12/CXCR4 axis contributing to persistent airway inflammation and AHR during the later stage of RSV infection.
Functional imaging and targeted drug delivery in mice and patient tumors with a cell nucleolus-localizing and tumor-targeting peptide
Authors: Jing Renwei , Wang Qian , Chen Lu , Li Guangtao , Li Ruibin , Zhang Leijie , Zhang Hongbing , Zuo Bingfeng , Seow Yiqi , Qiao Xin , Xu Jingyuan , Chen Jun , Song Tianqiang , Yin HaiFang 
Published: April 2022

Abstract
Tumor-targeting peptides have profound clinical implications in early detection and delineation of microscopic lesions for surgical resection, and also delivery of therapeutics with reduced systemic toxicity. Here, we demonstrate that a peptide (RS), selected from a rationally-designed variant library of a reported hepatocellular carcinoma (HCC)-targeting peptide P47, enables discrimination of HCC from noncancerous tissues in orthotopic HCC mice and patient biopsies, and delineation of micrometastases in lung, with up to 21-fold contrast between tumor and surrounding liver, significantly higher than P47. Importantly, RS targets non-small cell lung (NSCLC) and colon cancers in mice and patient biopsies, with higher selectivity for highly proliferative tumor nodules. Moreover, RS localizes to cell nucleoli of HCC, NSCLC, breast, colon and cervical cancer cells and induces cell nucleolar stress when conjugated with chemotherapeutic Oxaliplatin (OXA) (RS-OXA), demonstrating both cellular and subcellular targeting. RS-delivered OXA elicits significant tumor retardation in orthotopic HCC mice with markedly reduced systemic toxicity compared to OXA alone. Injection of fluorescence-labeled RS enables dynamic visualization of tumor growth in RS-OXA-treated subcutaneous HCC mice. Our study demonstrates that RS targets a spectrum of tumors and localizes to cell nucleolus, and enables functional imaging and targeted delivery of OXA in HCC mice, and thus provides a versatile tool for tumor imaging and targeted therapeutics.
Research on Cavitation Effect of Microtextured Array
Authors: Jiang Yuanyuan , Yan Zhijun , Zhang Shengwei , Sun Haocheng , Shen Ziyu 
Published: April 2022

Abstract
In this paper, the surface texture parameters and distribution patterns are studied by numerical simulation and experiment. First, a three-dimensional micro-textured CFD fluid lubrication model with cavitation effect is established, and different texture arrays are designed to study the influence of different distribution modes on bearing capacity, friction coefficient and pressure distribution of the oil film. Then, the simulation results are further analyzed and verified by the visualized plane slider experimental platform, and the formation rules of cavitation bubbles in the micro-textured array, as well as the influences of the surface shape and different distribution modes of the micro-textured array on the cavitation bubbles are discussed. The results show that the existence of cavitation is one of the main reasons for the microtexture to increase the bearing capacity of the oil film, which cannot be ignored in the simulation study. The texture array with single symmetric orientation is the best to improve the oil film bearing capacity, and the bearing performance is the best when the texture inclination angle is 26.6°.The friction coefficient of the asymmetrically oriented textured array is 29.4% lower than that of the non-textured sample.The results in the experiment are consistent with the simulation.
Integrating cell interaction with transcript factors to obtain a robust gene panel for prognostic prediction and therapies in cholangiocarcinoma
Authors: Wang Tingjie , Xu Chuanrui , Xu Dan , Yang Xiaofei , Liu Yaxin , Li Xiujuan , Li Zihang , Dang Ningxin , Zhang Zhijing , Ye Kai 
Published: April 2022

Abstract
Background
The efficacy of immunotherapy in cholangiocarcinoma (CCA) is blocked by its high degree of tumor heterogeneity.
Methods
We constructed empirical Bayes and Markov random field models to calculate transcription factors, interaction genes, and associated signaling pathways involved in cell-cell communication using single cell RNAseq data. Then, we analyzed the immune exhaustion mechanism in the CCA progression.
Results
We found that VEGFA positive macrophages with the high level of LGALS9 could interact with HAVCR2 to promote exhaustion of CD8 T cells in CCA. Transcript factors SPI1 and IRF1 could up-regulate the expression of LGALS9 in VEGFA positive macrophages. Subsequently, we obtained a panel containing 54 genes through the model, which could identify the subtype S2 with high expression of immune checkpoint genes that are suitable for immunotherapy. Moreover, we found that patients in subtype S2 with a higher mutation ratio of MUC16 accompanied with immune exhausted genes such as HAVCR2 and TIGIT. Finally, we constructed a nine-gene eLBP-LASSO-COX risk model which was designated as tumor microenvironment risk score (TMRS).
Conclusions
eLBP could simultaneously analyze the interaction genes, pathways and transcription factors involved in the cell communication. The TMRS panel was revealed to be a reliable tool for prognostic prediction and chemotherapeutic decision-making in cholangiocarcinoma.