bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Energy and Gold Markets Interact with Islamic Stocks? Evidence from the Asia-Pacific Markets
Authors: Avazkhodjaev Salokhiddin , Mukhamedov Farkhod , Usmonov Jaloliddin 
Published: May 2022

This paper examines the influence of Islamic stock price uncertainty on energy and gold commodity prices by using daily data from September 25, 2014 to March 12, 2021. We employ thе MGАRCH-M mоdеl with DCC and BEKK approaches tо assess interrelationship selected series. Based on empirical estimations, we achieved the following results. Firstly, empirical results from MGАRCH–M mоdеl estimations Islamic stock price uncertainty have а significаnt positive effect оn energy and gold commodities price. Secondly, non-causality tests results bared bi-directional variance transmissions of Islamic stock prices and the conditional variations of energy and gold commodities prices. Finally, for the pre-pandemic periods, results of the GIRF analaysis provided that the innovation shоcks оf Islamic stock price returns have а negative effects оn energy and gold price uncertainty. Indeed, for the response of ongoing pandemic periods shows Islamic stock price returns have а negative interact оn commodities price volatility, except energy stock price.
Influence of Electricity Consumption of Industrial and Business, Electricity Price, Inflation and Interest Rate on GDP and Investments in Indonesia
Authors: Adi Tri Wahyu , Prabowo Eri , Prasadjaningsih Oetami 
Published: May 2022

This study aims to explore the influence of electricity consumption, electricity price, inflation and interest rate on GDP and investments in Indonesia in the period 2001-2018. This paper is explanatory research. A Generalized Structured Component Analysis was a component-based approach to Structural Equation Modelling has used as a research model. The empirical analysis uses time-series data of GDP, Electricity Consumption, Electricity Price, Inflation Rate, Interest Rate, Investments and GDP in Indonesia in the period 2001-2018. The findings of this study are electricity consumption has a significant positive effect on GDP and electricity price. Electricity price has an insignificant positive effect on electricity consumption and investment. GDP has a significant positive effect on electricity consumption but insignificant on investment and inflation. Investment has an insignificant negative effect on electricity consumption and inflation. Inflation has a significant positive effect on the interest rate, vice versa, but is insignificant to electricity consumption. The interest rate has an insignificant positive effect on investment. The Originality of this study, namely previous studies focused more on the relationships and causality between Electricity Consumption, FDI, GDP, while in this study the emphasis is more on predictions between latent variables using the GSCA. In previous studies using total electricity consumption, in this study, the latent variable of electricity consumption is formed by industry electricity consumption and business electricity consumption which is productive consumption in increasing GDP. This study uses a multi-variate study consisting of Electricity Consumption of Industrial and Business, Electricity Price, Investment, GDP variables, and adding Inflation Rate and Interest Rate that represent macro-economic conditions in the research model.
Fractional Order Modeling of 1,2,3 DOF Robot Dynamic
Authors: Cerón-Morales Israel 
Published: May 2022

<p class="15">The fractional order modeling method of robot dynamics with one, two and three degrees of freedom is introduced. The stability of the fractional order model is proved by using the second-order Lyapunov method. A basic physical parameter is considered, that is, the inertial mass of the connecting rod. Freecad software is used for mechanical design. The dynamic models of 2-<span style="font-family: 'Times New Roman';">DOF</span> and 3-<span style="font-family: 'Times New Roman';">DOF</span> robots are established, and their motion trajectories are given in plane (x, y) and space (x, y, z) respectively. The model is programmed on the development card based on microcontroller. The advantage of the development card lies in its peripheral output<span style="font-family: 'Times New Roman';">,</span> <span style="font-family: 'Times New Roman';">because</span> it has two analog output channels<span style="font-family: 'Times New Roman';">,</span> <span style="font-family: 'Times New Roman';">which are sent</span> to the oscilloscope. The results are consistent with the proposed model.</p>
Navigating financial toxicity in patients with cancer: A multidisciplinary management approach
Authors: Smith Grace L. , Banegas Matthew P. , Acquati Chiara , Chang Shine , Chino Fumiko , Conti Rena M. , Greenup Rachel A. , Kroll Juliet L. , Liang Margaret I. , Pisu Maria , Primm Kristin M. , Roth Michael E. , Shankaran Veena , Yabroff K. Robin 
Published: May 2022

AbstractApproximately one‐half of individuals with cancer face personal economic burdens associated with the disease and its treatment, a problem known as financial toxicity (FT). FT more frequently affects socioeconomically vulnerable individuals and leads to subsequent adverse economic and health outcomes. Whereas multilevel systemic factors at the policy, payer, and provider levels drive FT, there are also accompanying intervenable patient‐level factors that exacerbate FT in the setting of clinical care delivery. The primary strategy to intervene on FT at the patient level is financial navigation. Financial navigation uses comprehensive assessment of patients’ risk factors for FT, guidance toward support resources, and referrals to assist patient financial needs during cancer care. Social workers or nurse navigators most frequently lead financial navigation. Oncologists and clinical provider teams are multidisciplinary partners who can support optimal FT management in the context of their clinical roles. Oncologists and clinical provider teams can proactively assess patient concerns about the financial hardship and employment effects of disease and treatment. They can respond by streamlining clinical treatment and care delivery planning and incorporating FT concerns into comprehensive goals of care discussions and coordinated symptom and psychosocial care. By understanding how age and life stage, socioeconomic, and cultural factors modify FT trajectory, oncologists and multidisciplinary health care teams can be engaged and informative in patient‐centered, tailored FT management. The case presentations in this report provide a practical context to summarize authors’ recommendations for patient‐level FT management, supported by a review of key supporting evidence and a discussion of challenges to mitigating FT in oncology care. CA Cancer J Clin. 2022;72:437‐453.
Analisis Usahatani Jagung Pipilan Berdasarkan Status Penguasaan Lahan di Desa Babakanloa Kecamatan Pangatikan Kabupaten Garut
Authors: Lestari Nur Intan , Erawan Wahid , Awaliyah Fitri , Febrianti Tintin 
Published: May 2022

ABSTRAK Tanaman Jagung Pipilan merupakan komoditas tanaman pangan unggulan di Kecamatan Pangatikan Kabupaten Garut. Penelitian ini bertujuan untuk menganalisis usahatani jagung pipilan berdasarkan status penguasaan lahan. Penelitian ini dilaksanakan di Desa Babakanloa Kecamatan Pangatikan Kabupaten Garut pada bulan Oktober sampai November 2021. Jenis data yang digunakan pada penelitian ini yaitu data primer dan data sekunder. Pengambilan sampel pada penelitian ini menggunakan metode purposive sampling dengan persentase pengambilan sampel 10% dari jumlah populasi, sehingga diperoleh sampel petani pemilik 18 orang, dan petani penyakap 18 orang. Analisis data yang digunakan dalam penelitian ini adalah kuantitatif deskriptif dengan menganalisis biaya produksi usahatani, penerimaan, pendapatan, dan kelayakan usahatani. Hasil penelitian menunjukkan bahwa rata-rata total biaya produksi yang dikeluarkan oleh petani pemilik sebesar Rp 19.210.239/Ha/Musim Tanam, sedangkan petani penyakap sebesar Rp. 11.145.867/Ha/Musim Tanam. Sistem bagi hasil usahatani jagung pipilan di daerah penelitian untuk petani penyakap adalah 50% dari hasil keseluruhan hasil produksi. Usahatani jagung pipilan yang dijalankan oleh petani pemilik dan petani penyakap layak untuk diusahakan dengan rata-rata nilai R/C rasio sebesar 1,6 untuk petani pemilik, dan nilai R/C rasio sebesar 1,3 untuk petani penyakap. Kata kunci: Analisis Usahatani, Jagung Pipilan, Status Penguasaan Lahan.
Association of Vitamin D Gene Polymorphisms With HCV Infection Outcome
Authors: Neamatallah M. , Serria M. S. , El‐Bendary M. , El‐Gilany A.‐H. , Alhawarey A. , Abed S. , Setate Y. A. , Ammar O. A. 
Published: May 2022

Background: Vitamin D derivatives and their receptor (VDR) are immune-response modulators in many diseases including malignancies, metabolic conditions, and infections. We hypothesized that one or more variants of VDR single nucleotide polymorphisms (SNPs) are associated with hepatocellular carcinoma (HCC) in hepatitis C virus (HCV) cirrhotic patients.Materials and Methods: A total of 861 subjects were recruited and classified as spontaneous viral clearance (SVC, n = 127), chronic hepatic cirrhosis (CHC, n = 392), and HCC (n = 342). Standard routine laboratory tests were performed and clinical features noted. All individuals were genotyped for seven SNPs spanning the VDR using real-time PCR.Results: Genotype frequencies of SNPs rs7970376, rs11568820, rs4516035, rs2228570 (Fok1), rs1544410 (Bsm-1), and rs731236 (Taq1), but not rs739837, were variously altered in CHC and HCC compared with SVC, and in HCC compared to CHC (all p &lt; 0.001). The most powerful was rs7970376, which brought an OR (95% CI) of 7.14 (4.64–10.98) for HCC compared to SVC (p = 0.001). The carriage of the AGTAC haplotype of five SNPs were linked to CHC compared to SVC at OR 2.88 [95% CI 1.2–6.9] (p = 0.017) and with HCC compared to CHC at OR 1.54 [95% CI = 1.04–2.27 (p = 0.031).Conclusion: SNPs in VDR may have a potential role in the outcomes of patients with HCV infection. VDR SNPs; rs7970376, rs11568820, rs4516035, rs2228570 (Fok1), rs1544410 (Bsm-1), and rs731236 (Taq1) could be used as molecular markers to predict the risk of HCC.
Microvascular Dynamics and Hemodialysis Response of Patients With End-Stage Renal Disease
Authors: Lee Jen-Shih , Lee Lian-Pin 
Published: May 2022

In our previous analysis of three sets of hemodialysis studies, we found that patients possessing higher hematocrit have a higher filtration coefficient KSo and more fluid being restituted from the tissue. A new dynamic analysis is developed to reveal how the plasma protein concentration, restitution volume, and plasma volume are changing over the time course of 240 min hemodialysis. For patients with the filtration coefficient KSo as 0.43 or 5.88 ml/min/mmHg, we find that the restitution rate would reach 50% of the extraction rate in 5.3 or 57.4 min, respectively. By the end of hemodialysis, the restitution rate of both patients asymptotically approaches a value of 0.93 ml/min which is slightly higher than the extraction rate of 9.03 ml/min. The plasma volume drops by 10% of the total plasma volume in 11 min for patients with low KSo and drops by 2.1% and turns around to an increasing trend in 5.6 min for patients with high KSo. These results suggest that the filtration coefficient acts like a facilitator in restituting more fluid from the tissue to compensate for the loss of plasma volume due to extraction. The hematocrit data of three sets of hemodialysis also indicate that significant microvascular blood volume is shifted from small veins toward the venous side of macrocirculation. A better understanding of how the factors examined here cause hypovolemia can be the basis for one to modify the hemodialysis process such that the development of hypovolemia can be avoided over the course of hemodialysis.
Sex Differences in Efficacy and Safety After Left Atrial Appendage Closure: A 4.3-Year Follow-Up Analysis
Authors: Chen Yuyi , Zhang Yonghua , Qu Lulu , Chen Chunyu , Su Xi , Chen Yanhong 
Published: May 2022

IntroductionWomen are related to higher stroke risk and poorer outcome after stroke attack in patients with non-valvular atrial fibrillation (NVAF). The sex differences in efficacy and safety after left atrial appendage closure (LAAC) have remained elusive. This retrospective study aimed to investigate the safety, feasibility, and clinical outcomes of LAAC between women and men.MethodsFrom 2014 to 2018, 395 patients who underwent LAAC in our center were enrolled in this retrospective study. Baseline clinical characteristics, procedural parameters, and postoperative follow-up data were collected and compared between women and men.ResultsThe study included 154 women and 241 men. Compared with men, women were older (68.1 ± 7.9 vs. 64.6 ± 8.8, p &lt; 0.01**), with higher CHA2DS2-VASc score (4.0 ± 1.7 vs. 3.0 ± 1.6, p &lt; 0.01**). During the mean follow-up duration of 1,566 days (4.3 years), there were 39 major adverse cardiovascular events (MACE, including 19 cardiovascular or unexplained deaths, 15 ischemic strokes, and 5 major bleedings) recorded in 34 patients. The overall rate of ischemic stroke was 0.9 per 100 patient-years, and the overall rate of MACE was 2.1 per 100 patient-years. The cardiovascular or unexplained death and major bleeding were comparable between women and men. Compared with men, women had lower rates of ischemic stroke, fatal or disabling ischemic stroke, MACE, and fatal or disabling MACE, but none of them reached statistical differences (HR: 0.361, p = 0.099, HR: 0.429, p = 0.276, HR: 0.600, p = 0.170, and HR: 0.621, p = 0.254, respectively). In the adjusted analyses with multivariate Cox regression models, women had a lower fatal or disabling ischemic stroke rate compared with men (HR: 0.100, p = 0.041).ConclusionLeft atrial appendage closure was feasible and safe for patients of both genders. The ischemic stroke, cardiovascular or unexplained death, and major bleeding were comparable between women and men. However, women were the independent protective factors against fatal or disabling ischemic stroke after LAAC implantation.
Microvascular Dysfunction in Skeletal Muscle Precedes Myocardial Vascular Changes in Diabetic Cardiomyopathy: Sex-Dependent Differences
Authors: Loai Sadi , Sun Xuetao , Husain Mansoor , Laflamme Michael A. , Yeger Herman , Nunes Sara S. , Cheng Hai-Ling Margaret 
Published: May 2022

AimTo uncover sex-related microvascular abnormalities that underlie the early presentation of reduced perfusion in leg skeletal muscle in a type II rat model of diabetic cardiomyopathy.Methods and ResultsDiabetes was induced using a non-obese, diet-based, low-dose streptozotocin model in adult female (18 diabetic, 9 control) and male rats (29 diabetic, 11 control). Time-course monitoring over 12 months following diabetes induction was performed using echocardiography, treadmill exercise, photoacoustic imaging, flow-mediated dilation (FMD), histopathology, and immunohistochemistry. Diabetic rats maintained normal weights. Hypertension appeared late in both diabetic males (7 months) and females (10 months), while only diabetic males had elevated cholesterol (7 months). On echocardiography, all diabetic animals maintained normal ejection fraction and exhibited diastolic dysfunction, mild systolic dysfunction, and a slightly enlarged left ventricle. Exercise tolerance declined progressively and early in males (4 months), later in females (8 months); FMD showed lower baseline femoral arterial flow but unchanged reactivity in both sexes (5 months); and photoacoustic imaging showed lower tissue oxygen saturation in the legs of diabetic males (4 months) and diabetic females (10 months). Myocardial perfusion was normal in both sexes. Histopathology at the final timepoint of Month 10 (males) and Month 12 (females) revealed that myocardial microvasculature was normal in both vessel density and structure, thus explaining normal perfusion on imaging. However, leg muscle microvasculature exhibited perivascular smooth muscle thickening around small arterioles in diabetic females and around large arterioles in diabetic males, explaining the depressed readings on photoacoustic and FMD. Histology also confirmed the absence of commonly reported HFpEF markers, including microvessel rarefaction, myocardial fibrosis, and left ventricular hypertrophy.ConclusionExercise intolerance manifesting early in the progression of diabetic cardiomyopathy can be attributed to decreased perfusion to the leg skeletal muscle due to perivascular smooth muscle thickening around small arterioles in females and large arterioles in males. This microvascular abnormality was absent in the myocardium, where perfusion levels remained normal throughout the study. We conclude that although skeletal muscle microvascular dysfunction of the vasculature presents at different levels depending on sex, it consistently presents early in both sexes prior to overt cardiac changes such as rarefaction, fibrosis, or hypertrophy.
Effect of Sodium-Glucose Co-transporter Protein 2 Inhibitors on Arrhythmia in Heart Failure Patients With or Without Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
Authors: Yin Ziwei , Zheng Huizhen , Guo Zhihua 
Published: May 2022

AimArrhythmic events such as atrial fibrillation (AF) are tightly associated with an increased risk of heart failure (HF). Previous studies have shown inconsistent results regarding the association between sodium-glucose co-transporter 2 inhibitors (SGLT2i) and the risk of arrhythmia. The purpose of this study was to investigate the association of SGLT2i treatment with arrhythmia outcomes in clinical trials of patients with HF.MethodsWe searched Embase, PubMed, Web of Science, Medline, The Cochrane Library, and JAMA databases to identify appropriate randomized controlled trials (RCTs) of SGLT2i interventions. Endpoint outcomes included AF, atrial flutter (AFL), AF/AFL, ventricular fibrillation (VF), ventricular tachycardia (VT), VF/VT, and bradycardia. A random-effects model was used for the meta-analysis of all outcomes. The risk of bias and quality of evidence was assessed by using the Cochrane tool and assessment framework.ResultsOut of 1,725 citations, 9 trials were included in this study, with follow-up from 4 weeks to 52 weeks for 10,344 participants (mean age 68.27 years; 69.62% of participants were men). Compared with placebo, SGLT2i reduced the incidence of AF by 37% [ratio risk (RR) 0.63; 95% confidence interval (CI) 0.45–0.87; p &lt; 0.05] and AF/AFL by 34% (RR 0.66; 95% CI 0.49–0.90; p &lt; 0.05).ConclusionsSGLT2i can reduce the risk of cardiac arrhythmias, particularly the AF. Our study provides strong evidence for recommending the use of SGLT2i in patients with HF.Systematic Review RegistrationPROSPERO, identifier: CRD42022296696.
Right Ventricular Dysfunction Predicts Outcome in Acute Heart Failure
Authors: Berrill Max , Ashcroft Eshan , Fluck David , John Isaac , Beeton Ian , Sharma Pankaj , Baltabaeva Aigul 
Published: May 2022

AimThe severity of cardiac impairment in acute heart failure (AHF) predicts outcome, but challenges remain to identify prognostically important non-invasive parameters of cardiac function. Left ventricular ejection fraction (LVEF) is relevant, but only in those with reduced LV systolic function. We aimed to assess the standard and advanced parameters of left and right ventricular (RV) function from echocardiography in predicting long-term outcomes in AHF.MethodsA total of 418 consecutive AHF patients presenting over 12 months were prospectively recruited and underwent bedside echocardiography within 24 h of recruitment. We retrospectively assessed 8 RV and 5 LV echo parameters of the cardiac systolic function to predict 2-year mortality, using both guideline-directed and study-specific cutoffs, based on the maximum Youden indices via ROC analysis. For the RV, these were the tricuspid annular plane systolic excursion, RV fractional area change, tissue Doppler imaging (TDI) peak tricuspid annular systolic wave velocity, both peak- and end-systolic RV free wall global longitudinal strain (RV GLS) and strain rate (mean RV GLSR), RV ejection fraction (RVEF) derived from a 2D ellipsoid model and the ratio of the TAPSE to systolic pulmonary artery pressure (SPAP). For the LV, these were the LVEF, mitral regurgitant ΔP/Δt (MR dP/dt), the lateral mitral annular TDI peak systolic wave velocity, LV GLS, and the LV GLSR.ResultsA total of 7/8 parameters of RV systolic function were predictive of 2-year outcome, with study cutoffs like international guidelines. A cutoff of &lt; −1.8 s–1 mean RV GLSR was associated with worse outcome compared to &gt; −1.8 s–1 [HR 2.13 95% CI 1.33–3.40 (p = 0.002)]. TAPSE:SPAP of &gt; 0.027 cm/mmHg (vs. &lt; 0.027 cm/mmHg) predicted worse outcome [HR 2.12 95% CI 1.53–2.92 (p &lt; 0.001)]. A 3-way comparison of 2-year mortality by LVEF from the European Society of Cardiology (ESC) guideline criteria of LVEF &gt; 50, 41–49, and &lt; 40% was not prognostic [38.6% vs. 30.9 vs. 43.9% (p = 0.10)]. Of the 5 parameters of LV systolic function, only an MR dP/dt cutoff of &lt; 570 mmHg was predictive of adverse outcome [HR 1.63 95% CI 1.01–2.62 (p = 0.047)].ConclusionWith cutoffs broadly like the ESC guidelines, we identified RV dysfunction to be associated with adverse prognosis, whereas LVEF could not identify patients at risk.
3D Physical Experimental Study of Shield–Strata Interaction Under Dynamic and Static Disturbance
Authors: Yang Shengli , Yue Hao , Zhai Ruihao , Cui Zhiwei , Wei Xia 
Published: May 2022

With the increasing depth and intensity of coal mining, there is an increasing risk to the working face due to high static load and periodic breakage of the roof. The relation between the support and the surrounding rock under static–dynamic coupling loading disturbance is an important factor affecting the stability of the working face. In this study, a 3D physical modeling platform is developed to study the interaction between the shield and strata under dynamic and static disturbance. In the experiment, the static load is set to 0, 0.5, 1, and 2 MPa, respectively. The different dynamic load is realized by changing the fall height of the iron plate. The change in hydraulic support resistance is recorded by the pressure monitoring system. The displacement of the coal wall is monitored by using an infrared rangefinder. The results show that the change in static load and dynamic load will affect the support resistance and coal wall displacement. With the increase in dynamic load, coal wall displacement, and bracket resistance increase, the increase is not linear. The larger the dynamic load, the greater the increase. Static load change has little effect on bracket resistance, and the impact on coal wall displacement is large. With the increase in static load, coal wall displacement is reduced and then increased. In static load, for the stability of coal wall, there is a threshold; below the threshold, the static load can improve the stability of coal wall, exceed the threshold, but accelerate the destruction of coal wall. At the same time, the stability coefficient of the quarry bracket and surrounding rock is defined. The sensitivity analysis of the main parameters is carried out. The method of controlling the stability of the quarry bracket and surrounding rock is proposed.