bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship Between Lateral Nasal Wall Collapse and Nasal Obstruction
Authors: Bae Mi Rye , Choi Woo Ri , Jang Yong Ju 
Published: July 2022

Objectives: In clinical practice, lateral nasal wall collapse during forced inspiration is widely regarded as a sign of nasal obstruction or criterion indicating nasal valve surgery. This study aims to evaluate the relationship between the degree of lateral nasal wall collapse and subjective nasal obstruction. In addition, factors related to lateral nasal wall collapse were also investigated. Methods: In this study, lateral nasal wall collapse is determined by the degree of lateral nasal wall triangle (LNWT) area reduction on frontal view during forced inspiration compared to quiet inspiration. LNWT area ratio of the patient and control groups was compared. The relationship between the lateral nasal wall collapse and clinical factors including symptom scores, nasal valve angles, skin thickness were evaluated. Results: The average LNWT area ratio of the patient (n = 24) and control groups (n = 27) was 0.96 and 0.83 respectively ( P = .001). Symptom score (NOSE and VAS) is not related to the degree of lateral nasal wall collapse. Moreover, nasal valve angle and skin thickness were also not related to the degree of lateral nasal wall collapse. In 14 of the 19 patients, the more obstructed side corresponded to the side of narrower nasal valve angle, and 5 were not. Conclusion: Lateral nasal wall collapse is not related to a patients’ nasal obstruction.
Temporal profile of angiogenesis and expression of extracellular matrix-related genes in rat brains following experimental intracerebral hemorrhage
Authors: Yang A-Li , Zhou Hua-Jun , Tang Tao , Luo Jie-Kun , Cui Han-Jin 
Published: July 2022

Background: Angiogenesis is essential for the repair process after intracerebral hemorrhage (ICH). Methods: Given the importance of the extracellular matrix (ECM) in angiogenesis, we analysed the temporal profile of angiogenesis in rat brains on days 4, 7, and 21 after ICH. To this end, we compared the expression of ECM-related genes between ICH-induced and sham-operated groups using a complementary DNA (cDNA) array. We further measured protein expression using western blot and immunohistochemistry assays. Fluorescein isothiocyanate (FITC)-dextran was injected into the tail vein to examine the angioarchitecture in the perihematomal region. Results: Among the 88 ECM-related genes, we identified 42, 50, and 38 genes that were significantly upregulated on days 4, 7, and 21 after ICH, respectively ( P < 0.05). Particularly, collagens, integrins, and matrix metalloproteinases (MMPs) were significantly increased on day 4 post-ICH and continued to increase at the other time points. Western blot and immunohistochemistry analyses showed a comparable trend in the upregulation of MMPs. Compared to the sham group, FITC-dextran labelling demonstrated decreased perfusion and increased vascular permeability in the perihematomal region in the ICH group. Doxycycline, an MMP inhibitor, significantly reduced angiogenesis ( P < 0.05). Conclusions: The results of this study indicate that MMPs are involved in modulating angiogenesis following ICH.
How Does Globalization Influence the Impact of Tourism on Carbon Emissions and Ecological Footprint? Evidence from African Countries
Authors: Ehigiamusoe Kizito Uyi , Shahbaz Muhammad , Vo Xuan Vinh 
Published: July 2022

Tourism and globalization are considered as drivers of economic growth since they boost income, job opportunities, infrastructural development, international trade, foreign direct investment, capital flows, and technological diffusion. However, the economic benefits of tourism and globalization could occur at the expense of increased energy consumption (from fossil fuels) and other pollution-intensive activities that worsen environmental degradation, especially in countries with lax institutions and environmental standards. The roles of tourism, globalization, and their interaction term on environmental degradation have not been thoroughly investigated. Hence, this study analyzes the moderating role of globalization on the impact of tourism on environmental degradation (carbon emissions and ecological footprint) in 31 African countries using different dimensions of tourism and globalization. It uncovers the marginal effect of tourism on environmental degradation at different levels of globalization. It utilizes strategies that account for cointegration, dynamism, endogeneity, heterogeneity, cross sectional dependency, and causality. Evidence from this study shows that globalization and its dimensions play favorable moderating roles on the impact of tourism on carbon emissions. The marginal effect of tourism on carbon emissions decreases as globalization increases, suggesting that a simultaneous increase in tourism and globalization can mitigate carbon emissions. However, no evidence to show that globalization can mitigate the environmental impact of tourism on ecological footprint. The findings differ probably because carbon emissions and ecological footprint measure different aspects of environmental degradation. This analysis emphasizes the need for countries to consider the interaction between tourism and globalization in their quest to ensure environmental sustainability. JEL Classification: F64, Q53, Z32
Effectiveness of early cardiac rehabilitation in patients with heart valve surgery: a randomized, controlled trial
Authors: Xue Wei , Xinlan Zhang , Xiaoyan Zheng 
Published: July 2022

Objective Complications of heart valve surgery lead to physical inactivity and produce harmful effects. This study aimed to investigate the role of a cardiac rehabilitation program and its long-term effect in patients after heart valve surgery. Methods We performed a single-blind, randomized, controlled trial. Patients with heart valve surgery were randomly assigned to receive early cardiac rehabilitation (intervention group, 44 patients) or the usual care (control group, 43 patients). The intervention group performed sitting, standing, and walking exercises, followed by endurance training. The control group received usual care and did not engage in any physical activity. Physical function was assessed by the Short Physical Performance Battery (SPPB) and other measurement tools. Results The intervention group showed a significant beneficial effect regarding physical capacity as shown by the SPPB and the 6-minute walking test at hospital discharge, and a better long-term effect was achieved at 6 months compared with the control group. An improvement in physical function (e.g., the SPPB) after hospital discharge predicted follow-up mortality (odds ratio = 0.416, 95% confidence interval: 0.218–0.792). Conclusion Early cardiac rehabilitation appears to be an effective approach to improve the physical function and survival of patients with heart valve surgery.
Biomechanical evaluation of the reconstruction of the calcar femorale in femoral neck fractures: a comparative finite element analysis
Authors: Gao Zhihao , Ma Jianxiong , Wang Ying , Lu Bin , Bai Haohao , Sun Lei , Jin Hongzhen , Zhang Zijian , Ma Xinlong 
Published: July 2022

Objective Femoral neck fractures are common. We evaluated the biomechanical performance of an internal fixation method based on traditional three cannulated screws (3CS) inserted from below the fracture in the direction of the calcar femorale in the treatment of Pauwels III femoral neck fracture. Methods We constructed and evaluated a three-dimensional model of a Pauwels III femoral neck fracture with four models of internal fixation (3CS, and 150°, 155°, and 160° nailing angles) for reconstruction of the calcar femorale, by finite element analysis (FEA). Results The peak stress values at the fracture ends in the 3CS, 150°, 155°, and 160° nailing angle models were 30.052 MPa, 33.382 MPa, 34.012 MPa, and 29.858 MPa; peak stress values for internal fixed stress were 315.121 MPa, 228.819 MPa, 198.173 MPa, and 208.798 MPa; and the maximum displacement of the femoral head was 13.190 mm, 13.183 mm, 12.443 mm, and 12.896 mm, respectively. Conclusion FEA showed that the new nailing methods and the 160° nailing angle for reconstruction of the calcar femorale showed better performance in resisting shearing force for Pauwels III femoral neck fracture, with better mechanical properties, than those with the other three models. These findings can provide a clinical reference.
Nomogram predicts the prognosis of patients with thymic carcinoma: A population-based study using SEER data
Authors: Huang Yang-Yu , Liu Xuan , Liang Shen-Hua , Wu Lei-Lei , Ma Guo-Wei 
Published: July 2022

Background: Thymic carcinoma (TC) is a rare malignant tumor that can have a poor prognosis, and accurate prognostication prediction remains difficult. We aimed to develop a nomogram to predict overall survival (OS) and cancer-specific survival (CSS) based on a large cohort of patients. Methods: The Surveillance Epidemiology and End Results (SEER) database was searched to identify TC patients (1975–2016). Univariate and multivariable Cox regression analyses were used to identify predictors of OS and CSS, which were used to construct nomograms. The nomograms were evaluated using the concordance index (C-index), calibration curve, receiver operating characteristic curve, and decision curve analysis (DCA). Subgroup analysis was performed to identify high-risk patients. Results: The analysis identified six predictors of OS (Masaoka stage, surgical method, lymph node metastasis, liver metastasis, bone metastasis, and radiotherapy) and five predictors of CSS (Masaoka stage, surgical method, lymph node metastasis, tumor size, and brain metastasis), which were used to create nomograms for predicting three-year and five-year OS and CSS. The nomograms had reasonable C-index values (OS: 0.687 [training] and 0.674 [validation], CSS: 0.712 [training] and 0.739 [validation]). The DCA curve revealed that the nomograms were better for predicting OS and CSS, relative to the Masaoka staging system. Conclusion: We developed nomograms using eight clinicopathological factors that predicted OS and CSS among TC patients. The nomograms performed better than the traditional Masaoka staging system and could identify high-risk patients. Based on the nomograms’ performance, we believe they will be useful prognostication tools for TC patients.
Headache at the chronic stage of cerebral venous thrombosis
Authors: Bossoni Alexandre Souza , Peres Mario Fernando Prieto , Leite Claudia da Costa , Fortini Ida , Conforto Adriana Bastos 
Published: July 2022

Background Headache is the most frequent symptom of cerebral venous thrombosis (CVT) but there is limited information about the frequency and phenotype of headache, weeks to months after cerebral venous thrombosis (post-cerebral venous thrombosis headache, PCH). Objective To assess the frequency, characteristics and predictors of PCH. Methods In this cross-sectional study, the frequency and characteristics of PCH were assessed in cerebral venous thrombosis survivors. Patients were interviewed between six months and five years after the cerebral venous thrombosis diagnosis. Clinical and imaging characteristics at the time of cerebral venous thrombosis diagnosis, as well as history of headache prior to cerebral venous thrombosis were compared in subjects with (GroupPCH) and without PCH (Groupcontrol). Results Subjects (n = 100; 82% women) were assessed, on average, at 1.1 ± 1.6 years of follow-up. PCH was present in 59% of the patients, phenotypes of tension-type-like headache were present in 31/59 (52.6%) and of migraine-like headache in 16/59 (27.1%). History of primary headache prior to cerebral venous thrombosis was significantly more common (OR: 6.4; 95% CI: 1.7–36.3) in GroupPCH (33.9%) than in Groupcontrol (7.3%). Conclusion PCH was present in more than half of the patients. History of prior headache may be a risk factor for PCH. Prospective studies are required to confirm these findings and determine mechanisms, as well as interventions for prevention and treatment of PCH.
Clinical Outcomes of Osteochondral Fragment Fixation Versus Microfracture Even for Small Osteochondral Lesions of the Talus
Authors: Nakasa Tomoyuki , Ikuta Yasunari , Sumii Junichi , Nekomoto Akinori , Kawabata Shingo , Adachi Nobuo 
Published: July 2022

Background: The bone marrow stimulation (BMS) technique is performed for osteochondral lesions of the talus (OLTs) with a lesion size of <100 mm2. The lesion defect is covered with fibrocartilage, and the clinical outcomes deteriorate over time. In contrast, the osteochondral fragment fixation can restore the native articular surface. The difference in clinical outcomes between these procedures is unclear. Purpose: To compare the clinical outcomes of BMS and osteochondral fragment fixation for OLTs and examine the characteristics of patients with poor clinical outcomes of BMS. Study Design: Cohort study; Level of evidence, 3. Methods: In total, 62 ankles in 59 patients with OLTs were included. BMS was performed for 26 ankles, and fixation was performed for 36 ankles. Clinical outcomes, including the American Orthopaedic Foot & Ankle Society (AOFAS) Ankle Hindfoot Scale and bone marrow edema (BME) as identified on magnetic resonance imaging, were compared between the 2 groups. On computed tomography scans, the lesion location was compared with or without BME in each group. Results: The AOFAS scores in the fixation group (97.3 ± 4.3 points) were significantly higher than those in the BMS group (91.3 ± 7.7 points), even when the lesion size was <100 mm2 ( P < .05). When comparing the ankles with or without BME in each group, the AOFAS scores at the final follow-up were significantly lower for the ankles with BME (88.6 ± 7.8 points) than for those without BME (95.0 ± 6.1 points) in the BMS group ( P < .05). Lesions with BME in the sagittal plane were located more centrally than those without BME in the BMS group. In the fixation group, there were no significant differences in AOFAS scores and location of the lesion in ankles with or without BME. Conclusion: The clinical outcomes of osteochondral fragment fixation are superior to those of BMS in OLTs, even for lesions sized <100 mm2. Fixation is recommended even for small lesions, especially for more centralized lesions in the medial and lateral sides of the talus.
Liberty and Responsibility
Authors: Bastid-Bruguière Marianne 
Published: July 2022

AbstractAlthough China adopted in 1948 the Universal Declaration of Human Rights largely inspired by her delegate Zhang Pengchun (1892–1957), individual liberty remains a key issue in cultural dialogues between China and Europe. However, culture is an ongoing process with no territorial boundaries, affecting every human being differently. European freedom is becoming increasingly restricted the more it focuses on meeting social and environmental needs. More broadly, the concept of responsibility that expresses solidarity between humans, belongs to all cultures and could provide the common norm of a global ethic.
Services and evidence of irremediable market failure in rich countries: Australian experience
Authors: Fforde Adam 
Published: July 2022

AbstractA large and increasing share of economic activity in modern rich economies can be shown to lie outside what mainstream neoclassical economics itself says it can be applied to: according to neoclassical economics, such activities are unsuited to markets. Since World War II rich economies have de-industrialised, shifted to services. Since the 1970s neoclassical economics has come to dominate policy advice. This worldview justifies state interventions when there is remediable market failure, but it ignores irremediable market failure, where its theory says that markets cannot work efficiently (such as where there is joint production or own consumption). Servicisation, this article argues, has increased and is increasing the extent to which neoclassical economics is, in its own terms, ‘knowably ignorant’. This is because, where service provision is subject to irremediable market failure, neoclassical economics, in its own terms, is inapplicable. The GDP [Gross Domestic Product] share of sub-sectors serving diverse human needs, such as aged care and education, is large and rising. Such sub-sectors are dominated by joint production, manifest as diverse outputs (complex and inter-related changes in the welfare of their diverse clients). Setting aside questions of the wider ‘scientific’ validity of neoclassical theory, the article focuses on its assertion that markets cannot generate economically efficient outcomes in such activities. Arguing that the constrained optimisation of its conceptual world cannot happen in the case of joint production and own consumption of service outputs, neoclassical theory reports itself as unable to determine optimal resource allocation, and so by implication cannot fulfil its role as the foundational basis of state economic policy. Yet the literature shows that the coverage of this theoretical result is not publicised – it is ‘knowable’ but not widely known. The article concludes that, as neoclassical economics is foundational to contemporary state policy, both GDP data and neoclassical theory show that it, and markets, are knowably and increasingly inapplicable. Therefore, mainstream policy thinking continues to face an increasing ‘state of ignorance’, and the cognitive foundations of state policy are correspondingly weak.
Thrombosis in Myeloproliferative Neoplasms: A Single Center Experience of Using Whole Blood Platelet Aggregation Studies for Risk Assessment and Thromboprophylaxis
Authors: Manoharan Arumugam , Gemmell Rosalie , Cavanaugh Lauren , Shadood Noor 
Published: July 2022

Thromboembolic complications are the most common causes of morbidity and mortality in patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPN); and prevention of these complications remains a significant clinical challenge. Effective thromboprophylaxis in MPN patients generally requires use of anti-platelet therapy, commonly aspirin; however, there are no standardized or universally accepted guidelines regarding the dose of aspirin. This study evaluates the usefulness of whole blood platelet aggregation (WBPA) studies to identify patients at risk for thrombosis and to achieve safe and effective long term thromboprophylaxis. One hundred and thirty-two consecutive patients were enrolled into this study. WBPA studies were performed at diagnosis in 125 patients to identify those with platelet hyperactivity (deemed to be at risk for thrombosis) and repeated 4 weeks after commencement of anti-platelet therapy to ascertain the efficacy. In patients with incomplete drug effect, treatment was revised and the study repeated until optimum effect was achieved. Results of the WBPA studies and anti-platelet therapy requirements were correlated with the underlying driver mutations and various international prognostic score of thrombosis for essential thrombocythemia (IPSET- Thrombosis) sub-groups. WBPA studies showed varying degrees of platelet hyper-activity in 115 patients. Based on these results, the patients were commenced on anti-platelet therapy comprising aspirin (dose ranging from 100mg twice or thrice weekly to 400mg daily) and clopidogrel (75mg daily) alone or in combination with aspirin or odorless garlic. None of the patients developed thrombosis during the follow up period ranging from 1-23 years (median 8yrs), while on the prescribed, individualized anti-platelet therapy. No significant differences were noted in terms of aspirin dose requirements between the JAK-2 positive and CALR or MPL positive patients, and, among the four IPSET-Thrombosis sub-groups. Patients with normal (9) or hypo (1) – activity were not given any anti-platelet therapy at diagnosis. Conclusion Routine use of WBPA studies enables safe and effective risk-adapted thromboprophylaxis in MPN patients, irrespective of the underlying driver mutation and their risk predicted by the IPSET- thrombosis criteria.
Parental experience of parent-mediated intervention for children with ASD: A systematic review and qualitative evidence synthesis
Authors: Jurek Lucie , Leadbitter Kathy , Falissard Bruno , Colin Cyrille , Touzet Sandrine , Geoffray Marie-Maude 
Published: July 2022

While the effectiveness of parent-mediated interventions in the field of autism spectrum disorder is well documented, information on the experience of parents involved in parent-mediated interventions is limited. We performed a systematic review with qualitative evidence synthesis to explore the experience of parent-mediated interventions in parents of children with autism spectrum disorder. PubMed, Scopus, PsycINFO, CINAHL, and Sociology Collection were searched from the date of their creation until 25 February 2022. Qualitative studies reporting parents’ experience of parent-mediated interventions were included. Two independent reviewers assessed the risk of bias. The findings of the selected studies were extracted and synthesized using the meta-aggregation method. The results are reported according to PRISMA and ENTREQ guidelines. A total of 23 studies were synthesized representing 345 participants. We found 34 categories that were summarized in four synthesized themes: barriers to implementation and logistical issues, feeling overwhelmed and stressed (a need for support), facilitators of implementation, and empowerment in the parent and improvement in the child. Parents’ experience of parent-mediated interventions in autism spectrum disorder is balanced between positive outcomes for them and their child, emotional struggles, and some difficulties in implementing parent-mediated interventions. Based on these results, we propose new ways to improve implementation of parent-mediated interventions and research in the field. Lay abstract The effectiveness of parent-mediated interventions in the field of autism spectrum disorder is well documented but information on the experience of parents involved in parent-mediated interventions is limited. This study is the first synthesis of evidence concerning the experience of parents involved in parent-mediated interventions. It synthesizes the voice of 345 parents across the world into four general themes: barriers to implementation and logistical issues, feeling overwhelmed and stressed (a need for support), facilitators of implementation, and empowerment in the parent and improvement in the child. The findings of our study provide evidence that parent-mediated interventions should be adapted to the needs of each family. Specific care and support should be offered to parents in addition to parent-mediated interventions. Our study, however, highlights which outcomes are important to parents and should be considered in future studies.