bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer-Related Lymphedema: Clinical and Epidemiological Features in Mexico
Authors: López-Montoya Luis , Cabanillas Yucari L. , Aguirre Joceline S. , Saenz-Ramirez K. Gabriela , Zarate-Sánchez Maria T. , D. Lopez Angel 
Published: July 2022

Backgroundː There is a lack of clinical and epidemiological knowledge about cancer-related lymphedema in Mexico. The objective of this study is to present a broad and deep report of cancer-related lymphedema’s clinical characteristics and epidemiological features based on the analysis of CRL patients’ data, collected from a specialized rehabilitation clinic in Mexico.
Methodsː This is a cohort study based on the analysis of clinical data gathered between 2015 and 2022. The study was developed in a private clinic that specializes in oncological patients’ rehabilitation. Clinical assessments and interviews were performed to collect each case’s clinical history, considering diverse clinical characteristics and demographic information, classified in a matrix, and statistically evaluated.
Resultsː Among 307 lymphedema patients, gender distribution was represented by 87.9% (270) female and 12.1% (37) male; mean age of 54.5 years (± 32.5); 79.8% of the patients corresponded to breast cancer diagnosis, the rest of them were associated with other 19 different types of cancer. 90.2% of patients underwent some lymph node removal procedure, 68.1% of patients received fractioned radiotherapy sessions, and 87.7% received some chemotherapy scheme treatment. 64% of patients had a diagnosis of lymphedema and had onset symptoms of lymphedema in the first 5 years after oncological interventions and/or cancer diagnosis, most of them during the first 2 years. The general distribution of clinical staging was: 23.7% in stage 0; 20.1% in stage I; 44.6% in stage II, and in stage III 11.4%. Regarding body mass index, it was found a mean of 26.7 BMI. 61.2% of patients ranged between overweight and obesity. 43.3% of patients with CRL reported a disability to perform one or more activities due to lymphedema. 80% of patients had no physical activity or performed under the minimal physical activity recommended for the population group they belong.
Conclusionː This study reports broad epidemiological and clinical features of a group of cancer-related lymphedema patients in Mexico, it was possible to identify diverse potential factors and relations that influence the clinical features of CRL; it is necessary to explore all factors and the interactions among them for a better understanding of CRL patients in the country.
Comparative Evaluation of Dexmedetomidine, Ketamine & their Combination for Epidural Analgesia in Orthopedic Surgeries of the lower Limb
Authors: Mishra Deeksha , Chakole Vivek 
Published: July 2022

Background: Epidural anesthesia is a perioperative pain control treatment that has a variety of applications in anaesthesiology. It could be used as as a primary anaesthetic, although it's most usually utilised as an adjuvant for management of pain. It could be a one-time shot or a continuous infusion for a long-drawn therapeutic intervention. Apart from the potential for significant analgesia, its use minimises the need for other anaesthetics and analgesics, lowering the risk of adverse effects. It has also been proven to lower the level of cortisol, to facilitate the resumption of bowel function, reduce the risk of Pulmonary embolism and deep vein thrombosis in the post-operative phase, while minimizing the duration of institutional stays.
Aim: Comparison and Evaluation of the effect of the drugs dexmedetomidine , ketamine & them together as a combination in addition to bupivacaine, as an adjuvant for intermittent epidural top ups for lower limb orthopaedic surgeries .
Study Design: Prospective observational study.
Place and duration of Study: The study will be conducted over a period of 2 years and 6 months in the department of anaesthesiology, Jawaharlal Nehru medical college and Acharya vinoba bhave rural hospital, wardha.
Methodology: Our prospective, comparitive observational study included 90 patients randomly assigned into 3 sets of 30 each, one was administered dexmedetomidine epidurally, one was given ketamine and one was given their combination epidurally [1]. The quality and duration of analgesia provided by all 3 groups were then compared to find out which of them provides better and prolonged pain relief. Along with analgesia, the other parameters assessed were hemodynamic response, sedation and any other side effects.
Expected Results: We're attempting to establish the hypothesis that the combination of both the drugs is better than dexmedetomidine or ketamine administered individually. It has been proved in various researches that epidural ketamine prolonged the duration of analgesia, [2] but it was less than epidural dexmedetomidine. We expect that the combination would decrease the postoperative rescue analgesics requirements and less hemodynamic alterations hence providing greater patient satisfaction as compared to the two drugs separately.
Knowledge, Attitude and Practices among Undergraduate Medical Students Regarding Surgical Correction of Refractive Errors; a Cross-sectional Study
Authors: Batool Syedah Kanza , Batool Rabisa , Jamal Kanwal , Sheroze Muhammad Waqaruddin , Ramzan Muhammad Adil , Siddiqui Syeda Afia 
Published: July 2022

Aim: This study was aimed to assess the knowledge, attitude and practices regarding refractive error correction surgeries among undergraduate medical students.
Study Design: In this study cross-sectional study design was used.
Duration and Place of Study: The study was conducted amongst the undergraduate MBBS students studying at Dow Medical College, Karachi. The duration of study was seven months (August, 2019 till February, 2020).
Methods: A sample size of 189 was calculated for the study with confidence level 95% and confidence limit 5%. Data was collected through a validated self-administered questionnaire which was divided in five subsections used to gain information regarding participant’s demographics, knowledge, attitude and practices regarding refractive error surgeries. Data was analyzed using IBM SPSS V.22.
Results: In our study 189 students with a mean age of 21±1.8 years were included. Among the participants 112 (59.3%) had refractive errors. Glasses were used by majority 76 (67.9%) of participants for visual correction. Use of refractive error correction methods at all times was reported by 72 (66.7%) participants. Majority of respondents 142 (75.5%) had heard about surgery being used for correction of refractive errors. A large number of students 117 (66%) refused for surgery and fear of the outcomes was one of the reason for this refusal.
Conclusion: We found that majority of the participants were aware about refractive error correction surgeries yet most of them showed unwillingness for these procedures. This negative attitude must be changed to positive in order to enhance the practice for these procedures.
Gender differences in housework and childcare among Japanese workers during the COVID-19 pandemic
Authors:   CORoNaWork Project, Sakuragi Toshihide , Tanaka Rie , Tsuji Mayumi , Tateishi Seiichiro , Hino Ayako , Ogami Akira , Nagata Masako , Matsuda Shinya , Fujino Yoshihisa 
Published: July 2022

Abstract

Objectives
Although gender stereotypes regarding paid work and unpaid work are changing, most wives are responsible for taking care of the family and home in Japan. It is unclear how time spent on housework and childcare has changed between working men and women during the COVID-19 pandemic in Japan. The purpose of this study is to investigate how working men and women's responsibilities for housework and childcare changed during the COVID-19 pandemic in Japan depending on work hours, job type, the number of employees in the workplace, and frequency of telecommuting.

Methods
A cross-sectional analysis (N = 14,454) was conducted using data from an Internet monitoring study (CORoNa Work Project), which was conducted in December 2020. A multilevel logistic model with nested prefectures of residence was conducted to estimate the odds ratio (OR) for change in time devoted to housework and childcare among men and women adjusting for age, household income, presence of spouse who work, work hours, job type, the number of employees in the workplace, frequency of telecommuting, and the incidence rate of COVID-19 by prefecture.

Results
More women tended to perceive that their time of housework and/or childcare had been changed (increased housework: OR 1.92, 95% CI [1.71–2.16], P &lt; .001; decreased workhours: 1.66 (1.25–2.19), P &lt; .001: increased childcare: OR 1.58, 95% CI [1.29–1.92], P &lt; .001; decreased childcare: 1.11 (0.62–2.00), P = .719).

Conclusions
The time spent by women on housework and childcare changed significantly compared to men during the COVID-19 pandemic in Japan.
Guanabenz ameliorates disease in vanishing white matter mice in contrast to sephin1
Authors: Witkamp Diede , Oudejans Ellen , Hu‐A‐Ng Gino V. , Hoogterp Leoni , Krzywańska Aleksandra M. , Žnidaršič Milo , Marinus Kevin , de Veij Mestdagh Christina F. , Bartelink Imke , Bugiani Marianna , van der Knaap Marjo S. , Abbink Truus E. M. 
Published: July 2022

AbstractObjectiveVanishing white matter (VWM) is a leukodystrophy, characterized by stress‐sensitive neurological deterioration and premature death. It is currently without curative treatment. It is caused by bi‐allelic pathogenic variants in the genes encoding eukaryotic initiation factor 2B (eIF2B). eIF2B is essential for the regulation of the integrated stress response (ISR), a physiological response to cellular stress. Preclinical studies on VWM mouse models revealed that deregulated ISR is key in the pathophysiology of VWM and an effective treatment target. Guanabenz, an α2‐adrenergic agonist, attenuates the ISR and has beneficial effects on VWM neuropathology. The current study aimed at elucidating guanabenz's disease‐modifying potential and mechanism of action in VWM mice. Sephin1, an ISR‐modulating guanabenz analog without α2‐adrenergic agonistic properties, was included to separate effects on the ISR from α2‐adrenergic effects.MethodsWild‐type and VWM mice were subjected to placebo, guanabenz or sephin1 treatments. Effects on clinical signs, neuropathology, and ISR deregulation were determined. Guanabenz's and sephin1's ISR‐modifying effects were tested in cultured cells that expressed or lacked the α2‐adrenergic receptor.ResultsGuanabenz improved clinical signs, neuropathological hallmarks, and ISR regulation in VWM mice, but sephin1 did not. Guanabenz's effects on the ISR in VWM mice were not replicated in cell cultures and the contribution of α2‐adrenergic effects on the deregulated ISR could therefore not be assessed.InterpretationGuanabenz proved itself as a viable treatment option for VWM. The exact mechanism through which guanabenz exerts its ameliorating impact on VWM requires further studies. Sephin1 is not simply a guanabenz replacement without α2‐adrenergic effects.
Integrated Triboelectric‐Electromagnetic‐Piezoelectric Self‐Rebounding Energy Harvester for Human Energy Harvesting
Authors: Xiao Yuan , Niu Mingyuan , Yang Leipeng , Liu Jinchao , Lv Xiaolai , Yang Pengcheng 
Published: July 2022

AbstractA self‐rebounded hybrid energy harvester from human foot motion is investigated. The hybrid energy harvester integrates electromagnetic generators (EMG), piezoelectric nanogenerators (PENG), and triboelectric nanogenerators (TENG) between the two magnetic poles. The harvester uses a pair of mutually exclusive magnetic poles instead of spring‐mass to realize reciprocating motion, which is designed to grow 6 cm, width 5 cm, and height 4 cm. Under low frequency (4 Hz), EMG, PENG, and TENG can deliver a high output power of 6.49 mW, 0.168 µW, and 90.72 µW, respectively. After charging the energy harvesting circuit, the capacitor can continuously output a stable 5 V DC voltage, and the charging performance of the harvester is better than that of a single nanogenerator unit. Besides, the harvester can continuously light up 80 LED lights. After carrying the harvester and jogging for a certain distance, a pedometer module is powered. It shows that the designed self‐rebounding human motion foot energy harvester has certain feasibility in the practical application of wearable devices. The device can be easily assembled under the shoes, demonstrating the great application prospects of the harvester as a sustainable self‐power device for wearable and portable electronics.
Synthesis of C‐Aryl Glycosides via Ru‐Catalyzed Remote C−H Glycosylation of 8‐Aminoquinoline Amides
Authors: Shi Wei‐Yu , Li Hu‐Yi , Gou Xue‐Ya , Luan Yu‐Yong , Zheng Nian , Niu Zhi‐Jie , Zhang Zhe , Liu Xue‐Yuan , Liang Yong‐Min 
Published: July 2022

AbstractC‐Aryl glycoside is a class of structural motifs with important medicinal value. Herein, a remote C−H glycosylation strategy enabled by Ruthenium(II)‐catalyzed with mostly α‐stereoselectivity is described. This approach exhibits great functional group compatibility with various glycosides and arylamides. A series of experiments provided strong evidence for the free radical mechanism and reversible C−H activation process, and a possible mechanism was proposed.magnified image
Ultralow‐Power Atomic‐Scale Tin Transistor with Gate Potential in Millivolt
Authors: Xie Fangqing , Ducry Fabian , Luisier Mathieu , Leuthold Juerg , Schimmel Thomas 
Published: July 2022

AbstractAfter decades of continuous scaling, further advancement of complementary metal‐oxide‐semiconductor (CMOS) technology across the entire spectrum of computing applications is today limited by power dissipation, which scales with the square of the supply voltage. Here, an atomic‐scale tin transistor is demonstrated to perform conductive switching between bistable configurations with on/off potentials ≤2.5 mV in magnitude. In addition to the low operation voltage, the channel length of the transistor is determined experimentally and with density‐functional theory to be ≤1 nm because the atoms instead of electrons are information carriers in this device. The conductance at on‐states of the bistable configurations varies between 1.2 G0 to 197 G0 (G0 = 2e2 h−1, e stands for the electron charge and h for Planck's constant). Thus, the device can supply driving current from 1 to ≈375 µA in magnitude for logic circuits with the drain‐source dc voltage at decades of millivolts. The switching frequency of the atomic‐scale tin transistor has reached 2047 Hz. Furthermore, the on/off potentials in millivolts can reduce the energy consumption in the interconnects of integrated circuits at least by ≈400 times. Therefore, the atomic‐scale tin transistor has prospects in digital circuits with ultralow‐power dissipation and can contribute to the sustainability of modern society.
Levels of tumor markers CEA/CA 19–9 in serum and peritoneal lavage predict postoperative recurrence in patients with pancreatic cancer
Authors: Hata Tatsuo , Chiba Kazuharu , Mizuma Masamichi , Masuda Kunihiro , Ohtsuka Hideo , Nakagawa Kei , Morikawa Takanori , Hayashi Hiroki , Motoi Fuyuhiko , Unno Michiaki 
Published: July 2022

AbstractAimThis study aimed to clarify the usefulness of tumor markers from peritoneal lavage in selecting patients with a high risk of recurrence and predicting site‐specific recurrence in patients with pancreatic cancer.MethodsThe levels of serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19–9 (sCEA/sCA 19–9) and paired peritoneal lavage CEA and CA 19–9 (pCEA/pCA 19–9) were measured in 90 patients with pancreatic cancer who underwent surgery. Using the cutoff values determined by maximally selected rank statistics for disease‐free survival (DFS), the risk of recurrence and its patterns were evaluated in combination with different markers and different test specimens.ResultsIn univariate and multivariate analysis, an elevated pCA 19–9 level (>1.3 U/mL) was an independent prognostic marker for both DFS (hazard ratio [HR], 2.391; P = .018) and overall survival (HR, 3.194; P = .033). Combination analyses contributed to further stratification of a very high risk of recurrence. Of the 58 patients with resectable pancreatic cancer who underwent curative resection, elevated pCA19–9 was also associated with inferior DFS and overall survival (OS). Patients with elevated pCA 19–9 levels were more likely to have an earlier onset of peritoneal recurrence than those with normal pCA 19–9 levels (P = .048, Gehan–Breslow–Wilcoxon test).ConclusionpCA 19–9 is a reliable marker for predicting postoperative recurrence in patients with pancreatic cancer after surgery. Further risk stratification can be achieved by using combination assays. The combination of pCA 19–9 and sCA19–9 also serves as a predictor of recurrence site‐specific recurrence.
Broadening the phenotypic spectrum of EVEN‐PLUS syndrome through identification of HSPA9 pathogenic variants in the original EVE dysplasia family and two sibs with milder facial phenotype
Authors: Pacio‐Miguez Marta , Parrón‐Pajares Manuel , Gordon Christopher T. , Santos‐Simarro Fernando , Rodríguez Jiménez Carmen , Mena Rocio , Rueda Arenas Inmaculada , F. Montaño Victoria Eugenia , Fernández María , Solís Mario , del Pozo Ángela , Amiel Jeanne , García‐Miñaur Sixto , Palomares‐Bralo María 
Published: July 2022

AbstractEVEN‐PLUS syndrome is a rare autosomal recessive disorder caused by biallelic pathogenic variants in the mitochondrial chaperone called mortalin, encoded by HSPA9. This genetic disorder, presenting with several overlapping features with CODAS syndrome, is characterized by the involvement of the Epiphyses, Vertebrae, Ears, and Nose (EVEN), PLUS associated findings. Only five individuals presenting with the EVEN‐PLUS phenotype and biallelic variants in HSPA9 have been published. Here, we expand the phenotypic and molecular spectrum associated with this disorder, reporting two sibs with a milder phenotype and compound heterozygous pathogenic variants (a recurrent variant and a novel one). Also, we confirm a homozygous pathogenic variant in the family originally reported as EVE dysplasia.
Stimuli‐Responsive Metal Complexes for Biomedical Applications
Authors: Amarsy Ivanna , Papot Sébastien , Gasser Gilles 
Published: July 2022

AbstractMetal‐based compounds have been widely used for biomedical applications. Their unique characteristics make them attractive for both therapeutic and diagnostic purposes. However, numerous issues including toxicity, poor aqueous solubility, and unfavorable biodistribution hamper their widespread use. To overcome these drawbacks, the concept of metal‐based prodrugs emerged. This field is particularly developed for applications in oncology. More precisely, tumor‐associated stimuli (e.g., pH variation, redox activity, enzyme overexpression, etc.) have been exploited to trigger the selective delivery of active metal‐based drugs to the tumor site. The main advances in this area are discussed in this Review.
Dual Nickel/Photoredox‐Catalyzed Site‐Selective Cross‐Coupling of 1,2‐Bis‐Boronic Esters Enabled by 1,2‐Boron Shifts
Authors: Wang Hui , Han Wangyujing , Noble Adam , Aggarwal Varinder K. 
Published: July 2022

AbstractSite‐selective transition‐metal‐catalyzed mono‐deboronative cross‐couplings of 1,2‐bis‐boronic esters are valuable methods for the synthesis of functionalized organoboron compounds. However, such cross‐couplings are limited to reaction of the sterically less hindered primary boronic ester. Herein, we report a nickel/photoredox‐catalyzed mono‐deboronative arylation of 1,2‐bis‐boronic esters that is selective for coupling of the more sterically hindered secondary/tertiary position. This is achieved by taking advantage of a 1,2‐boron shift of primary β‐boryl radicals to the thermodynamically favored secondary/tertiary radicals, which are subsequently intercepted by the nickel catalyst to enable arylation. The mild conditions are amenable to a broad range of aryl halides to give β‐aryl boronic ester products in good yields and with high regioselectivity. This method also allows stereodivergent coupling of cycliccis‐1,2‐bis‐boronic esters to givetrans‐substituted products.
Heterogenised Molecular Catalysts for Sustainable Electrochemical CO2 Reduction
Authors: Grammatico Domenico , Bagnall Andrew J. , Riccardi Ludovico , Fontecave Marc , Su Bao‐Lian , Billon Laurent 
Published: July 2022

AbstractThere has been a rapid rise in interest regarding the advantages of support materials to protect and immobilise molecular catalysts for the carbon dioxide reduction reaction (CO2RR) in order to overcome the weaknesses of many well‐known catalysts in terms of their stability and selectivity. In this Review, the state of the art of different catalyst‐support systems for the CO2RR is discussed with the intention of leading towards standard benchmarking for comparison of such systems across the most relevant supports and immobilisation strategies, taking into account these multiple pertinent metrics, and also enabling clearer consideration of the necessary steps for further progress. The most promising support systems are described, along with a final note on the need for developing more advanced experimental and computational techniques to aid the rational design principles that are prerequisite to prospective industrial upscaling.
Artificial neural network prediction of thermal and mechanical properties forBi2O3‐polybenzoxazinenanocomposites
Authors: Al Hassan Mohamadou , Derradji Mehdi , Ali Mohsen M. M. , Rawashdeh Abdullah , Wang Jun , Pan Zhong‐Cheng , Liu Wen‐Bin 
Published: July 2022

AbstractPolybenzoxazine (BA‐a) based nanocomposites with varying amounts of Bi2O3particles reinforcement (10, 20, and 30 wt%) were produced. The structures of the Bi2O3before and after surface silane treatment, as well as the structures of the BA‐a matrix and its nanocomposites, were all evaluated using Fourier transform infrared spectroscopy (FTIR). The thermal stability of the samples was evaluated by thermogravimetric analysis (TGA) and the resistance to bending was studied using the three‐point bending test. Then, an artificial neural network approach was used to estimate the thermal degradation and flexural strengths of the polybenzoxazine matrix and its nanocomposites. The results of the TGA analysis showed that when Bi2O3content increased, the char yield (Yc) of the nanocomposites also increased from 27.98% to 43.53% for the experimental data and from 27.95% to 43 0.57% for the prediction, with allSDs less than 0.02. Moreover, both the experimental and predicted values of the flexural strengths for the unfilled BA‐a displayed 100.40 and 102.96 MPa, respectively and these values increased to 119.65 and 114.95 MPa when 10 wt% of fillers were incorporated into the matrix. However, for higher filler contents, 20 and 30 wt%, these values decreased to 112.94 and 108.01 MPa for the experiments, and 106.35 and 103.20 MPa for the prediction, respectively. The very small deviations (<0.05) between the experimental and predicted values demonstrated that the prediction approach using the artificial neural network is reliable and accurate.