bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthetic drives for useful drug molecules through organocatalytic methods
Authors: Krishna Banik Bimal , Sahoo Biswa Mohan , Tiwari Abhishek , Tiwari Varsha , Jain Adya , Borah Preetismita 
Published: February 2022

Abstract
The treatment of various pathological conditions in human beings involves the use of safe and efficacious drug substances. But there are different complications associated with the treatment of various disease states including drug resistance, adverse drug reactions, toxicity, etc. To minimize these problems, there is an urgent need to develop new therapeutics with suitable pharmacokinetic and pharmacodynamic properties. So, the organocatalytic methods are emerged as a potential synthetic tool to accelerate the design of new drug candidates with improved physicochemical and pharmacological properties, selectivity, and efficiency for the treatment of life-threatening diseases. Organocatalytic reactions refer to the chemical reaction that is accelerated by organic catalysts instead of using organometallic catalysts. Organocatalysts are more advantageous in comparison to metallic catalysts because organocatalysts are cost-effective, stable, efficient, non-toxic, readily available, and easy to handle. In addition to this, the organocatalysis method involves an eco-friendly reaction by minimizing the formation of by-products and reducing the chemical hazards. Organocatalysts are categorized into four classes such as Lewis acids, Lewis bases, Bronsted acids, and Bronsted bases. These catalysts are generally involved in various reactions mechanisms such as Aldol reaction, Diels–Alder reactions, Michael Addition and Knoevenagal reactions, etc. The utility of organocatalyst in synthetic chemistry results in the development of medicinally active compounds with diverse structural features.
Transfer matrices and solution of the problem of stochastic dynamics of aerosol clusters by Monte Carlo method
Authors: Cheremisin Alexander A. 
Published: February 2022

Abstract
A Monte Carlo algorithm based on the use of transfer matrices is developed to describe the stochastic dynamics of the rotational--translational motion of aerosol clusters taking into account fluctuations in the molecular fluxes of the gas medium. In the general case, the cluster is immersed into a rarefied gas medium, the temperatures of its surfaces may differ from the temperature of the surrounding gas, for example, due to absorption of visible and infrared radiation. The motion of the cluster is described based on Langevin motion equations. The algorithm allows one to calculate parameters of the probability distribution of a six-dimensional vector consisting of components of the momentum and angular momentum vectors transmitted to the cluster by molecular flows. The numerical method allows one to apply preliminary analytical averaging modulo velocities of molecules for both the average values of the components of momentum and angular momentum and their correlation characteristics, which significantly reduces the calculation time.
Model reduction in Smoluchowski-type equations
Authors: Timokhin Ivan V. , Matveev Sergey A. , Tyrtyshnikov Eugene E. , Smirnov Alexander P. 
Published: February 2022

Abstract
In the present paper we utilize the Proper Orthogonal Decomposition (POD) method for model order reduction in application to Smoluchowski aggregation equations with source and sink terms. In particular, we show in practice that there exists a low-dimensional space allowing to approximate the solutions of aggregation equations. We also demonstrate that it is possible to model the aggregation process with the complexity depending only on dimension of such a space but not on the original problem size. In addition, we propose a method for reconstruction of the necessary space without solving of the full evolutionary problem, which can lead to significant acceleration of computations, examples of which are also presented.
Enacted category claims and tacit orientations to older identities in the telling of a sexually-explicit anecdote
Authors: Heinrichsmeier Rachel 
Published: February 2022

Abstract
This paper examines the identities – older and other – being claimed and attributed through the telling of a sexually-explicit anecdote by an older female client in a hair salon. I draw on the methods of conversation analysis and membership categorization analysis to analyse both the anecdote itself and the longer (3 min) sequence of which it was a part. I show that in telling this rather improper anecdote the client was able to enact membership of a just-become-valued category in a sequential environment where asserting membership of that category, as done by two of her co-participants, was illegitimate for her on the basis of age. I also argue that in choosing to tell an anecdote at this point rather than assert membership she orientated to that very illegitimacy, and thereby to her own older identity. The analysis and the subsequent discussion highlight the way orientations to ageing and other identities may be displayed less through the semantic surface of talk, than in the sequential structures and interactional practices of the unfolding encounter. As such this paper contributes both to membership categorization analytic research and to the burgeoning corpora of studies loosely categorisable as ‘discursive gerontology’.
Disinhibitory Circuitry Gates Associative Synaptic Plasticity in Olfactory Cortex
Authors: Canto-Bustos Martha , Friason F. Kathryn , Bassi Constanza , Oswald Anne-Marie M. 
Published: February 2022

Inhibitory microcircuits play an essential role in regulating cortical responses to sensory stimuli. Interneurons that inhibit dendritic or somatic integration act as gatekeepers for neural activity, synaptic plasticity, and the formation of sensory representations. Conversely, interneurons that selectively inhibit other interneurons can open gates through disinhibition. In the anterior piriform cortex, relief of inhibition permits associative LTP of excitatory synapses between pyramidal neurons. However, the interneurons and circuits mediating disinhibition have not been elucidated. In this study, we use an optogenetic approach in mice of both sexes to identify the inhibitory interneurons and disinhibitory circuits that regulate LTP. We focused on three prominent interneuron classes: somatostatin (SST), parvalbumin (PV), and vasoactive intestinal polypeptide (VIP) interneurons. We find that LTP is gated by the inactivation SST or PV interneurons and by the activation of VIP interneurons. Further, VIP interneurons strongly inhibit putative SST cells during LTP induction but only weakly inhibit PV interneurons. Together, these findings suggest that VIP interneurons mediate a disinhibitory circuit that gates synaptic plasticity during the formation of olfactory representations.SIGNIFICANCE STATEMENTInhibitory interneurons stabilize neural activity during sensory processing. However, inhibition must also be modulated to allow sensory experience shape neural responses. In olfactory cortex, inhibition regulates activity-dependent increases in excitatory synaptic strength that accompany odor learning. We identify two inhibitory interneuron classes that act as gatekeepers preventing excitatory enhancement. We demonstrate that driving a third class of interneurons inhibits the gatekeepers and opens the gate for excitatory enhancement. All three inhibitory neuron classes comprise disinhibitory microcircuit motifs found throughout the cortex. Our findings suggest that a common disinhibitory microcircuit promotes changes in synaptic strength during sensory processing and learning.
Synopsis of the order Juncales (Liliopsida) in Ukraine
Authors: Danylyk I. M. , Olshanskyi I. G. 
Published: February 2022

Juncales is an order of vascular plants with cosmopolitan distribution. Two families of Juncales are present in flora of Ukraine: Juncaceae and Cyperaceae. Through 1985–2021, we conducted comprehensive revision of Juncales in Ukraine. The aim of this research was to compile a checklist of Juncales species in the flora of Ukraine. Our research is based on herbarium materials, literature data and field trips. We collected data in many herbariums of Ukraine and other countries. Our understanding of the taxa was further supplemented by field observations in mountainous (Carpathians and Crimea) and plain territories of Ukraine. Also, we collected information about Juncales species from numerous literature sources. For each taxon, we provided nomenclatural citation and basic synonyms. According to our data, the order Juncales in the flora of Ukraine contains 188 species, belonging to 19 genera. Lists of Juncales species can be found in many thorough publications. For a long time, Checklist of Mosyakin & Fedoronchuk (1999) was the main list in the nomenclature of vascular plants in Ukraine. To date, many nomenclature and taxonomic changes have been accumulated. For example, we accept genera Schoenoplectiella and Oreojuncus here. Researchers have found many new species for the territory of Ukraine. This information can be found in numerous publications, but is fragmented. Therefore, we have compiled an updated summary of the Juncales species. In Ukrainian territory, Juncales species are considered both widespread and rare. We refer to the rarest species Carex alba, C. bicolor, C. bohemica, C. brunnescens, C. buxbaumii, C. depauperata, C. fuliginosa, C. globularis, C. heleonastes, C. lachenalii, C. loliacea, C. obtusata, C. pediformis, C. rupestris, C. strigosa, Cyperus longus, Eleocharis multicaulis, E. oxylepis, Fimbristylis bisumbellata, Juncus acutiflorus, J. soranthus, J. subnodulosus, Isolepis setacea, Luzula spicata, Schoenoplectus pungens, Trichophorum alpinum, T. cespitosum. Also, the following species are rare: Bolboschoenus yagara, Carex chordorrhiza, C. davalliana, C. dioica, C. hostiana, C. pauciflora, C. secalina, C. vaginata, Cladium mariscus, Eleocharis carniolica, Juncus capitatus, J. castaneus, J. littoralis, J. sphaerocarpus, J. thomasii, J. triglumis, Luzula alpinopilosa, L. sudetica, Schoenoplectiella mucronata, Schoenus ferrugineus.
Seasonal dynamics of Diptera in individual biotopes in the center of the European part of Russia
Authors: Ruchin A. B. , Esin M. N. 
Published: February 2022

In a changing climate, phenological observations are gaining new importance. They can tell what changes are taking place in certain environmental conditions. The studies were conducted in 2019 within the territory of the Republic of Mordovia (the center of the European part of Russia). Beer traps (beer as a bait) were used to collect Diptera. The material was collected in the period from April to October in different forest biotopes (pine forest, lime forest, aspen forest, birch forest and oak forest) and the air temperature was recorded at the same time. In total, more than 14.000 specimens of Diptera were recorded. Overall, 29 families were recorded. The largest number of families was observed for birch (23 families) and pine (24 families) forests, the smallest number – in aspen forest (16 families). The families Muscidae, Drosophilidae, Calliphoridae had the largest number of captured individuals (44.5%, 35.2%, 7.6% of the total number of individuals respectively). The highest number of individuals was captured in oak forest. The dynamics of abundance in all biotopes were similar and were characterized by the same number of declines and rises. The first small significant peak in the number of Diptera occurred in the first half of summer. A slight increase in the number of specimenі occurred in mid-June. In the second half of September, there was a gradual increase in the number and the maximum peak was recorded in mid-October, then there was a decline. The autumn increase in the number of Diptera in all five biotopes exceeded the summer peak by several times. This dynamic was typical for most families. However, species from the family Lonchaeidae had the peak in July. For our better understanding of the changes in the seasonal dynamics of the number of Diptera, long-term observations in different climatic zones are needed.
An overview of helminths of the European fire-bellied toad Bombina bombina (Amphi-bia, Anura) in the Volga River Basin
Authors: Chikhlyaev I. V. , Ruchin A. B. 
Published: February 2022

The helminthofauna of Bombina bombina (Linnaeus, 1761) has been studied to an unequal degree in different parts of the habitat. Thus, it has been studied in more detail in the west of its range (in the countries of central and eastern Europe) and in less detail in the center (in Belarus and Ukraine). There were few data on helminths of this host in the east of its range (in Russia). For the first time, an inventory of the helminthofauna in B. bombina was carried out for populations in the Volga River Basin. The results of our own research are presented and supplemented with information from other authors. We summarized scattered data on helminths from 390 specimens of amphibians collected over more than 40 years in the territory of five regions: Kaluga and Samara regions, the Republics of Mordovia, Tatarstan and Bashkortostan. The helminthofauna includes 21 species from three classes: Trematoda (15), Chromadorea (5) and Clitellata (1). For each species, we give the systematic position, localization, places of detection, geographical distribution and characteristics of the life cycle. The leech Helobdella stagnalis (Linnaeus, 1758) was first recorded in the European fire-bellied toad in Europe. Four species of trematodes are new to this amphibian species in Russia: Haematoloechus abbreviatus (Bychowsky, 1932), Paralepoderma cloacicola (Luhe, 1909), larvae, Tylodelphys excavata (Rudolphi, 1803), larvae and Astiotrema monticelli (Stossich, 1904), larvae. Another species of trematode – Strigea strigis (Schrank, 1788), larvae – was first recorded in this host within the boundaries of the Volga Basin. A specific parasite is the trematode Haematoloechus abbreviatus (Bychowsky, 1932). The number and composition of the species of helminths of the European fire-bellied toad vary in different regions; the structure of the helminth fauna is generally stable and includes three groups of species: adult and larval stages of trematodes, adult nematodes-geohelminths. The results of the study create a database for further population studies and contribute to the development of ideas about the distribution and formation of the amphibian helminth fauna in Europe, Russia and the Volga Basin.
Ethical violations and the publication of journal articles
Authors: Sawitri Anak Agung Sagung 
Published: February 2022

There is a high demand for publication in the form of scientific articles in reputable journals in the academic world in Indonesia. Research publication in reputable or accredited national journals is required for graduation from tertiary institutions for master level students.Publication in reputable international journals is also a requirement for doctoral-level students graduation.Â For teaching staff, research publication in the form of peer reviewed journal articles is also a requirement for higher levels in the academic career.Â The increasing demand for scientific publication also reported globally.Â Furthermore, various reported reasons for publication include adding work resumes, for job promotion, obtaining funding grants, competition among colleagues or proving supremacy, and even in some universities, the history ofÂ publications is used as the criteria for determining dissertation internal and external examiners.
The impact of hospital accreditation on patient safety culture in the health services implementation at Sanglah General Hospital, Bali
Authors: Indrayani Putu May , Januraga Pande Putu , Negara Surya 
Published: February 2022

Background and purpose: Hospital accreditation is carried out to evaluate hospitals' performance in providing patients with excellent and safe health services. One aspect of service quality is patient safety culture. This study aims to determine the impact of hospital accreditation on patient safety culture in health service implementation at the Sanglah General Hospital in Denpasar City, Bali Province.Methods: This study used a qualitative research design. In-depth interviews were conducted to 11 informants consisting of hospital management, clinicians and nurses which were chosen purposively since they were directly related to the assessment and supervision of health service providers at Sanglah Hospital. The interview guide was based on the Modified Manchester Patient Safety Framework (MaPSaF). Data were analyzed with a thematic approach.Results: The interview results show that the ten dimensions of patient safety culture had been implemented well but still need to be improved in the dimensions of giving priority to safety, system errors and responsibilities, recording incidents and best practices, learning and influencing change, also education and training of staff and teamwork. The maturity level of patient safety culture at Sanglah Hospital is at generative culture in four dimensions and at proactive culture on the six dimensions of patient safety culture.Conclusion: Accreditation had a positive impact on the maturity level of patient safety culture at a proactive level, mainly changes in knowledge, attitudes, and behavior in health service providers. However, in its implementation, there were still constrained on infrastructure, time, and energy.
The influence of deformation conditions of titanium alloys on the surface quality of the feather of compressor blades
Authors: Kachan О. , Ulanov S. 
Published: February 2022

Purpose of work. Improving the quality of manufacturing of blanks of compressor blades from titanium alloys by precision stamping.
Research methods and equipment. The research was carried out by precise stamping of blade blanks from the VT8 titanium alloy of the compressor of the D-436 aircraft engine at various temperatures of deformation.
Precise stamping of parts was carried out in one tool stroke from a preliminary blank obtained by extrusion from a rod with a diameter of 30 mm.
The research of the surface of the workpiece was carried out after processing by X-ray spectral analysis on a JSM6360LA scanning electron microscope.
Microhardness was measured on a PMT-3 device at a load of 50 g.
Investigations by precision stamping were also carried out on blades made of the OTCh-1 alloy of the input guide vane of the HPC of the D-136 helicopter engine and on the rotor blades of the compressor of the D-36 aircraft engine made of VT3-1 titanium alloy.
The obtained results. It is shown that the conditions of deformation of a titanium alloy blade blank by precise stamping have a significant effect on the quality of its surface (macrostructure and microstructure). The deformation temperature of the metal affects the macrostructure and microstructure of the surface during precision stamping of blades from titanium alloys.
Scientific novelty. It has been established that during precise stamping of blade blanks from titanium alloys, the deformation temperature has a significant effect on the quality of their surface. The values of the deformation temperature are determined, which provide a significant level of quality of the surface of the airfoil of the blades with precise stamping.
Practical value. The results obtained made it possible to develop multi-pass stamping of blade blanks from titanium alloys, when fractional deformation in one pass is applied, not exceeding 30%.
The heating temperature of the intermediate billet for deformation should be as close as possible to Тm within ± 10 °С.
СРАВНИТЕЛЬНЫЙ АНАЛИЗ БИЗНЕС-МОДЕЛЕЙ ЗАРУБЕЖНЫХ И ОТЕЧЕСТВЕННЫХ НЕФТЕСЕРВИСНЫХ КОМПАНИЙ
Authors: Белошицкий Алексей Васильевич 
Published: February 2022

Аннотация. Целью исследования является сравнение бизнес-моделей зарубежных и российских компаний, что может определить критерии технологического развития, дающие конкурентные преимущества каждой из сторон.
Методологическую базу исследования представляют основные теоретические понятия о природе формирования бизнес-моделей предприятия и принципы их функционирования на базе «ценностного» и «процессного» подходов. Признается первостепенность таких параметров, как привлекательность продукта компании для клиентов и партнеров, а также механизмов создания стоимости и извлечения прибыли. Отмечено, что такой элемент бизнес-модели, как новое технологическое предложение, способен обеспечить преимущество на нефтесервисном рынке. Названы основные модели инновационного развития (эндогенная, сетевая и экзогенная), их отличия и характеристики. Изучены особенности развития корпораций «Halliburton» и «Schlumberger», обеспечившие успех и технологическое лидерство в мировой нефтесервисной отрасли.
Результаты исследования. Установлено, что обновление производственных мощностей российских нефтесервисных предприятий возможно на основе любой из трех представленных моделей стимулирования инновационной активности или их комбинации. Предполагается, что способная к устойчивому развитию инновационная бизнес-модель российской нефтесервисной компании в условиях современной изменчивой рыночной ситуации должна отличаться гибкостью, способностью к оптимизации затрат, адаптивностью и быстрой реакцией на требования/предпочтения рынка.
Перспективы исследования заключаются в детальном анализе характера и особенностей взаимоотношений между нефтяной компанией-заказчиком и нефтесервисным подрядчиком, что представляет значительную и важную область исследований отраслевого бизнеса.
ИЗМЕРЕНИЕ «ЦИФРОВОЙ» ЭКОНОМИКИ И ПСЕВДОЭФФЕКТ ТЕХНОЛОГИЧЕСКОГО ДУАЛИЗМА
Authors: Сухарев Олег Сергеевич 
Published: February 2022

Аннотация. Цель исследования. Управляемое распространение цифровых технологий стало атрибутом экономической политики во многих странах, войдя в качестве базовой задачи в доктрину «Индустрия 4.0». Решение этой задачи требует учета исходного состояния технологического базиса экономики, готовности всех звеньев экономики к освоению новых технологий. Эффект технологического дуализма может оказывать сдерживающее влияние на распространение цифровых и иных технологий, что требует отдельного изучения. Целью исследования выступает построение методики оценки распространения цифровых технологий и идентификации эффекта технологического дуализма, который для российской экономики приобретает специфическое содержание.
Методологию исследования составляет теория технологического развития и эффективности функционирования объектов экономики, подходы в области экономических измерений и формирования алгоритма и методики оценки релевантных параметров.
Результат исследования состоит в том, что в российской экономике выявлен псевдоэффект технологического дуализма на основе анализа динамики основного капитала и перемещения труда между экономическими секторами. Его возникновение может блокировать технологическое развитие, не препятствуя при этом ходу процесса распространения цифровых технологий. Обоснованы два базовых варианта распространения цифровых технологий и предложена методика оценки масштаба их распространения в экономике с оценкой эффективности ввода, а также методика идентификации технологического дуализма. Показано, что отсутствие роста производительности при расширении компьютерной техники и сетевых технологий не является парадоксом, а составляет вполне закономерный итог, обусловленный не только капитальным вложением на внедрение этих технологий, но и необходимостью обучения персонала, а также исходным масштабом рынка продуктов, создаваемых объектами, осуществляющими ввод цифровых технологий.
Перспектива исследования. Для изучения изменений структуры технологической динамики на перспективу предложен инструмент технологической карты и портфеля, требующие расширенного статистического учета технологий и описывающих их параметров, позволяющие расширить представление о влиянии технологий на экономическое развитие и эффекте технологического дуализма.