bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERTANGGUNG JAWABAN PIDANA TERHADAP TERDAKWA TINDAK PIDANA PERZINAAN
Authors: Istiklal Istiklal , Rosadi Otong , Bakir Herman 
Published: February 2022

Pertanggung Jawaban Pidana Terhadap Terdakwa Tindak Pidana Perzinaan . Pada 70/PID.Sus/2020/PN-SWL Dan Putusan Nomor 90/Pid.B/2020/Pnbkt adalah pada Putusan Nomor 70/PID.Sus/2020/PN-SWL dimana terdakwa bersalah melakukan tindak pidana “dengan sengaja menjadi objek yang mengandung muatan pornografi dan seorang pria yang telah menikah, melakukan zina (overspel) dengan pidana penjara selama 8 (delapan) bulan. Hakim tidak mempertimbangan perbuatan dengan sengaja menjadi objek yang mengandung muatan pornografi yang ditur pada undang undang pornografi namun hanya menjatuhkan pidana terhadap perbuatan perzinaan dengan pidana mendekati maksimal yaitu pidana penjara selama 9 bulan. Pertanggungjawaban pidana tindak pidana perzinaan pada Putusan Nomor 90/PID.B/2020/PNBKT adalah “turut melakukan Perzinahan padahal diketahui masih terikat perkawinan yang sah”. Dalam hal ini terdakwa adalah seorang yang masih belum terikat perkawinan sehingga dalam penjatuhan pidananya, terdakwa adalah sebagai turut serta melakukan bukan pelaku utama atau “Dader”. Terdakwa dianggap bersalah karena mengetahui bahwa saksi Zulkifli masih terikat perkawinan yang sah dengan saksi Ismarni namun tetap melakukan perbuatan zinah dengan terdakwa zulkifli. Pertimbangan Hakim Terhadap Terdakwa Tindak Pidana Perzinaan Pada Putusan Nomor 70/PID.Sus/2020/PN-SWL Dan Putusan Nomor 90/Pid.B/2020/Pnbkt adalah pada Putusan Nomor 70/PID.Sus/2020/PN-SWL secara yuridis terpenuhinya unsur perzinaan dan unsur merekam perbuatan zina yang dilakukan. Pada Putusan Nomor 90/PID.B/2020/PNBKT pertimbangan yuridis Pasal 284 KUHP ayat (1) ke 1 terpenuhi sebagai orang yang turut serta melakukan perbuatan zina dengan seseorang yang dia ketahui orang tersebut masih terikat perkawinan.
PENERAPAN UNSUR TINDAK PIDANA PERSETUBUHAN TERHADAP ANAK YANG DISEBARKAN MELALUI MEDIA SOSIAL PADA PENYIDIKAN
Authors: Noviardi Jeki , Fitriati Fitriati , Bakir Herman 
Published: February 2022

Pertimbangan Penyidik Pada Satreskrim Polres Kerinci Dalam Penerapan Unsur Tindak Pidana Persetubuhan Terhadap Anak Yang Disiarkan Melalui Media Sosial adalah dengan hanya menerapkan unsur yang terdapat pada Pasal 76D jo Pasal 81 Ayat (1) Undang-undang RI No 35 tahun 2014, tentang perubahan atas Undang-Undang RI Nomor 23 Tahun 2002 Tentang Perlindungan Anak dan tidak mempertimbangkan perbuatan terdakwa merekam dan menyebar luaskan perbuatan persetubuhan tersebut dalam media sosial. Hal ini dilakukan dengan pertimbangan tingginya biaya pembuktian dan juga pertimbangan usia tersangka yang masih muda sehingga diharapkan dapat memperbaiki prilakunya. Kendala Yang Ditemui Penyidik Pada Satreskrim Polres Kerinci Dalam Penerapan Unsur Tindak Pidana Persetubuhan Terhadap Anak Yang Disiarkan Melalui Media sosial adalah hambatan yang menyangkut segi sumber daya manusia dari penyidik. Penyidik yang kurang memahami materi undang undang perlindungan anak yang telah diperbaharui yaitu Undang undang nomor 35 tahun 2014 tentang perubahan atas undang undang nomor 23 tahun 2002 tentang perlindungan anak juga dalam hal menerapkan undang undang informasi transaksi elektronik karena perbuatan tersebut direkam yang kemudian disebar luaskan. Namun dalam penyidikan ini penyidik sama sekali tidak menerapkan unsur unsur yang terdapat dalam perundang undangan ITE tersebut. Penyidik beralasan karena adanya kesulitan dalam hal pengumpulan bukti dan pengujian kebenaran alat bukti.
Simulation of beating modes during the rotary-oscillating movement of complex aerodynamic engineering with determination of the conditions of their occurrence
Authors: Kotliarov Volodymyr , Voloshchenko Oleksandr , Kuznetsov Oleksandr , Kushnirenko Mykola 
Published: February 2022

The aim of the article is to determine the conditions of occurrence of beating modes in a nonlinear high-order dynamic system with subsequent computer simulation of these modes. Methods of research of nonlinear oscillatory systems are applied with consideration of two cases of interrelation on rotation (weak and strong) between oscillatory circuits.
In the first of them, the conditions for the existence of beating modes are approximately the same values of the partial frequencies of longitudinal and lateral oscillating motions with a constant increase in the modulus of the phase shift between these oscillations (phase motion is unstable).
At strong forces of interconnection (coefficients of interrelation of various signs) modes of beating arise at close values of sizes of the main frequencies of the interconnected fluctuations lying in a range between partial frequencies. Such modes (in the absence of parametric interaction between the circuits) are possible when the conditions of stability of the biharmonic process are observed.
The study of the complex form of rotational-oscillating motion of an aerodynamic object at the initial stage includes the selection from the complete dynamic system of two interconnected self-oscillating contours of longitudinal and lateral motions as a basis (necessary conditions) for the existence of beating modes.
In cases of observance of existence conditions of single-frequency self-oscillating processes at occurrence of parametric interaction these processes can also pass to beating modes.
In practice (outside the resonant region of the main frequencies) this is often realized when the functional frequency of the contour of lateral motion includes components proportional to the parameters of longitudinal motion.
All these cases are supported by numerous model experiments.
Prevalence of restless legs syndrome in pregnant women: a systematic review and meta-analysis
Authors: Abdi Alireza , Shareef Omar Hussein , Dalvand Sahar , Gheshlag Reza Ghanei , Dehkordi Ali Hasanpour 
Published: February 2022

<p><strong>ABSTRACT</strong><br /><strong>BACKGROUND.</strong> Restless legs syndrome (RLS) is a neurological disorder characterized by sleep disorders, which leads to adverse health consequences in the mother and fetus. Studies have reported different prevalence rates for RLS in pregnant women. This systematic review and meta-analysis aimed to estimate the prevalence of RLS in pregnant women.<br /><strong>METHODS.</strong> A literature search was performed via national and international databases, including Scientific Information Database (SID), MagIran, IranMedex, Google Scholar, Science Direct, PubMed, ProQuest, and Scopus. In total, 31 articles were selected without a time limit. The random effects model was used to analyze the data, and the heterogeneity between the studies was examined using the I2 index. The analyses were performed in the Stata software, version 12 and R, version 4.<br /><strong>RESULTS.</strong> The reviewed studies (n=31) were conducted on a total sample size of 59,151, and the prevalence of RLS in pregnant women was estimated at 21.4% [95% confidence interval CI: 17.7-25.1]. Asia with a prevalence rate of 18.5%, [95% CI: 13.8-23.1] and Europe with a prevalence rate of 25.5%, [95% CI: 19.5-31.6] had the lowest and highest RLS prevalence, respectively. No significant correlations were observed between the prevalence of RLS, publication year of the articles (P=0.972), and participants’ age (P=0.202).<br /><strong>CONCLUSION.</strong> According to the results, RLS is highly common in pregnant women, and it is essential to identify women with RLS to control and eliminate the adverse consequences of the disorder.</p>
Immobility in mobility during Covid-19
Authors: Phan Anh 
Published: February 2022

While international education has long been characterised by mobility, the Covid-19 pandemic has shifted our attention to immobility as thousands of international students have experienced immobility in various ways, one of which is being stuck in their home countries. This paper records how such immobility entailed the feeling of confusion and detachment in an international doctoral student and her efforts to overcome physical immobility by making use of digital mobility. Through the sensemaking framework, this paper not only illuminates the consequences of disrupted mobility on an international doctoral student’s academic learning and sense of belonging but also highlights the student’ agency, which then offers a research area that may yield interesting insights in this unprecedented time of uncertainty.
Systematic Analysis of Molecular Characterization and Clinical Relevance of Liquid–Liquid Phase Separation Regulators in Digestive System Neoplasms
Authors: Zhang Yaxin , Li Jie , Feng Dan , Peng Xiaobo , Wang Bin , Han Ting , Zhang Yingyi 
Published: February 2022

Background: The role of liquid–liquid phase separation (LLPS) in cancer has also attracted more and more attention, which is found to affect transcriptional regulation, maintaining genomic stability and signal transduction, and contribute to the occurrence and progression of tumors. However, the role of LLPS in digestive system tumors is still largely unknown.Results: Here, we characterized the expression profiles of LLPS regulators in 3 digestive tract tumor types such as COAD, STAD, and ESCA with The Cancer Genome Atlas (TCGA) data. Our results for the first time showed that LLPS regulatory factors, such as Brd4, FBN1, and TP53, were frequently mutated in all types of digestive system tumors. Variant allele frequency (VAF) and APOBEC analysis demonstrated that genetic alterations of LLPS regulators were related to the progression of digestive system neoplasms (DSNs), such as TP53, NPHS1, TNRC6B, ITSN1, TNPO1, PML, AR, BRD4, DLG4, and PTPN1. KM plotter analysis showed that the mutation status of LLPS regulators was significantly related to the overall survival (OS) time of DSNs, indicating that they may contribute to the progression of DSN. The expression analysis of LLPS regulatory factors showed that a variety of LLPS regulatory factors were significantly dysregulated in digestive system tumors, such as SYN2 and MAPT. It is worth noting that we first found that LLPS regulatory factors were significantly correlated with tumor immune infiltration of B cells, CD4+ T cells, and CD8+ T cells in digestive system tumors. Bioinformatics analysis showed that the LLPS regulators’ expression was closely related to multiple signaling, including the ErbB signaling pathway and T-cell receptor signaling pathway. Finally, several LLPS signatures were constructed and had a strong prognostic stratification ability in different digestive gland tumors. Finally, the results demonstrated the LLPS regulators’ signature score was significantly positively related to the infiltration levels of CD4+ T cells, neutrophil cells, macrophage cells, and CD8+ T cells.Conclusion: Our study for the first time showed the potential roles of LLPS regulators in carcinogenesis and provide novel insights to identify novel biomarkers for the prediction of immune therapy and prognosis of DSNs.
Gene Expression Profile Reveals a Prognostic Signature of Non–MSI-H/pMMR Colorectal Cancer
Authors: Liu Zaoqu , Xu Hui , Ge Xiaoyong , Weng Siyuan , Dang Qin , Han Xinwei 
Published: February 2022

Studies have demonstrated that non–MSI-H/pMMR colorectal cancer (CRC) has a worse prognosis and relapse rate than microsatellite instability-high (MSI-H)/mismatch repair deficient (dMMR) CRC. Hence, searching for a novel tool to advance the prognostic management of non–MSI-H/pMMR CRC is vital. In this study, using three independent public cohorts and a clinical in-house cohort, we developed and validated a microsatellite stable–associated signature (MSSAS). The initial signature establishment was performed in GSE39582 (n = 454). This was followed by independent validation of this signature in The Cancer Genome Atlas–CRC (n = 312), GSE39084 (n = 54), and in-house cohort (n = 146). As a result, MSSAS was proven to be an independent risk factor for overall survival and relapse-free survival in non–MSI-H/pMMR CRC. Receiver operating characteristic analysis showed that MSSAS had a stable and accurate performance in all cohorts for 1, 3, and 5 years, respectively. Further analysis suggested that MSSAS performed better than age, gender, and the T, N, M, and AJCC stages, adjuvant chemotherapy, tumor mutation burden, neoantigen, and TP53, KRAS, BRAF, and PIK3CA mutations. The clinical validation was executed to further ensure the robustness and clinical feasibility of this signature. In conclusion, MSSAS might be a robust and promising biomarker for advancing clinical management of non–MSI-H/pMMR CRC.
Monocytic Myeloid-Derived Suppressor Cells Inhibit Myofibroblastic Differentiation in Mesenchymal Stem Cells Through IL-15 Secretion
Authors: Cheuk Yin Celeste , Xu Shihao , Zhu Dong , Luo Yongsheng , Chen Tian , Chen Juntao , Li Jiawei , Shi Yi , Zhang Yi , Rong Ruiming 
Published: February 2022

Background: Accumulating evidence indicates that mesenchymal stem cells (MSCs) are precursors of myofibroblasts, which play a vital role in renal fibrosis. The close interaction between MSCs and other immune cells regulates the development of multiple fibrosis-related diseases. However, the effect of myeloid-derived suppressor cells (MDSCs) on MSCs remains unexplored. Here, we investigated the effect of MDSCs on the myofibroblastic differentiation of MSCs.Methods: MSCs were induced to undergo myofibroblastic differentiation with transforming growth factor beta 1 (TGF-β1). M-MDSCs and G-MDSCs were sorted by flow cytometry. Supernatants derived from MDSCs were administered to cultured bone marrow MSCs (BM-MSCs) undergoing TGF-β1-induced myofibroblastic differentiation. Myofibroblastic differentiation was evaluated by immunostaining. The expression of fibrosis-related genes was determined by quantitative PCR and western blot analysis. In vitro, M-MDSC supernatant or M-MDSC supernatant with interleukin (IL)-15 mAbs was administered following unilateral renal ischemia-reperfusion injury (IRI) to observe the myofibroblast differentiation of renal resident MSCs (RRMSCs) in a murine model.Results: Myofibroblastic differentiation of MSCs was hindered when the cells were treated with MDSC-derived supernatants, especially that from M-MDSCs. The inhibitory effect of M-MDSC supernatant on the myofibroblastic differentiation of MSCs was partially mediated by IL-15-Ras-Erk1/2-Smad2/3 signaling. Treatment with M-MDSC supernatant ameliorated renal fibrosis and myofibroblastic differentiation in RRMSCs through IL-15. Additionally, M-MDSC supernatant increased M-MDSC infiltration in the kidney in a mouse IRI model. M-MDSC supernatant downregulated the adhesion and migration marker CD44 on the cell membrane of MSCs via IL-15.Conclusion: M-MDSC-derived supernatant inhibited the TGF-β1-induced myofibroblastic differentiation of MSCs through IL-15. Our findings shed new light on the effect of MDSCs on myofibroblastic differentiation and adhesion of MSCs, which might provide a new perspective in the development of treatment strategies for renal fibrosis.
An Integrated Analysis of the Identified PRPF19 as an Onco-immunological Biomarker Encompassing the Tumor Microenvironment, Disease Progression, and Prognoses in Hepatocellular Carcinoma
Authors: Yang Ming , Qiu Yiwen , Yang Yi , Wang Wentao 
Published: February 2022

Background: Targeting the mRNA splicing process has been identified as a therapeutic strategy for human cancer. PRPF19 is an RNA binding protein that is involved in pre-mRNA processing and repairing DNA damage; the aberrant expression of PRPF19 is potentially associated with carcinogenesis. However, the biological role of PRPF19 in hepatocellular carcinoma (HCC) is still elusive.Methods: Data obtained from TCGA, Oncomine, and GEO were used to investigate the PRPF19 expression level and its role in tumor immune infiltration, prognosis, and the tumor progression of cohorts from HCC. Using various databases and tools (UALCAN, TIMER, TISMO, and PathCards), we presented the potential mechanisms of PFPF19 upregulation, PRPF19-related pathways, and its biological functions in liver cancer.Results: For HCC, PRPF19 expression was found upregulated both in single tumor cells and tissues. Furthermore, the increased expression of PRPF19 was significantly correlated to clinical characteristics: advanced stage, vascular invasion, high AFP, and poor prognosis of HCC. According to the tumor-immunological analysis, we found that PRPF19 is positively correlated with infiltrating myeloid-derived suppressor cells (MDSCs). Moreover, the microenvironment of HCC tissues with high expression of PRPF19 is highly immunosuppressive (lower T-lymphocytes, multiple immune checkpoints upregulated). Patients with high expression of PRPF19 and high MDSCs had a worse survival prognosis as well. TP53 mutation may have a positive effect on PRPF19 expression via decreased promoter methylation of PRPF19. By TF-mRNA network analysis, key transcription factors (TFs) in TC-NER and PCS pathways (PRPF19 involved) were identified.Conclusion: This work implied that PRPF19 is associated with tumor immune evasion and progression, and serves as a prognostic marker for worse clinical outcomes with HCC. Thus, this critical regulator could serve as a potential therapeutic target of HCC.
Trace Element-Augmented Titanium Implant With Targeted Angiogenesis and Enhanced Osseointegration in Osteoporotic Rats
Authors: Yan Ran , Li Jinhua , Wu Qianju , Zhang Xiangkai , Hu Longwei , Deng Yuwei , Jiang Ruixue , Wen Jin , Jiang Xinquan 
Published: February 2022

Deteriorated bone quality in osteoporosis challenges the success of implants, which are in urgent need for better early osseointegration as well as antibacterial property for long-term stability. As osteoporotic bone formation tangles with angiogenic clues, the relationship between osteogenesis and angiogenesis has been a novel therapy target for osteoporosis. However, few designs of implant coatings take the compromised osteoporotic angiogenic microenvironment into consideration. Here, we investigated the angiogenic effects of bioactive strontium ions of different doses in HUVECs only and in a co-culture system with BMSCs. A proper dose of strontium ions (0.2–1 mM) could enhance the secretion of VEGFA and Ang-1 in HUVECs as well as in the co-culture system with BMSCs, exhibiting potential to create an angiogenic microenvironment in the early stage that would be beneficial to osteogenesis. Based on the dose screening, we fabricated a bioactive titanium surface doped with zinc and different doses of strontium by plasma electrolytic oxidation (PEO), for the establishment of a microenvironment favoring osseointegration for osteoporosis. The dual bioactive elements augmented titanium surfaces induced robust osteogenic differentiation, and enhanced antimicrobial properties. Augmented titanium implant surfaces exhibited improved bone formation and bone–implant contact under comprehensive assessment of an in vivo bone–implant interface. In conclusion, zinc- and strontium-augmented titanium surface benefits the osseointegration in osteoporosis via promoting osteogenic differentiation, exerting antibacterial efficacy, and stimulating early angiogenesis.
Association of Residential Proximity to the Coast With Incident Myocardial Infarction: A Prospective Cohort Study
Authors: Xiao-dong Zhuang , Shao-zhao Zhang , Xun Hu , Xin-xue Liao , Li-zhen Liao 
Published: February 2022

BackgroundLittle is known about how the residential distance to the coast is associated with incident myocardial infarction (MI) and which mechanisms may explain the association. We aim to explore this association using data from a prospective, population-based cohort with unprecedented sample size, and broad geographical coverage.MethodsIn this study, 377,340 participants from the UK Biobank were included.ResultsIt was shown that 4,059 MI occurred during a median 8.0 years follow-up. Using group (&lt;1 km) as reference, group (20–50 km) was associated with a lower risk of MI (hazard ratio, HR 0.79, 95% CI 0.64–0.98) and a U-shaped relation between distance to the coast and MI was shown with the low-risk interval between 32 and 64 km (pnon−linear = 0.0012). Using participants of the intermediate region (32–64 km) as a reference, participants of the offshore region (&lt;32 km) and inland region (&gt;64 km) were both associated with a higher risk of incident MI (HR 1.12, 95% CI 1.04–1.21 and HR 1.09, 95% CI 1.01–1.18, respectively). HR for offshore region (&lt;32 km) was larger in subgroup with low total physical activity (&lt;24 h/week) (HR 1.24, 95% CI 1.09–1.42, pinteraction = 0.043). HR for inland region (&gt;64 km) was larger in subgroup in urban area (HR 1.12, 95% CI 1.03–1.22, pinteraction = 0.065) and in subgroup of high nitrogen dioxide (NO2) air pollution (HR 1.29, 95% CI 1.11–1.50, pinteraction = 0.021).ConclusionWe found a U-shaped association between residential distance to the coast and incident MI, and the association was modified by physical activity, population density, and air pollution.
Prognostic Value of Global Longitudinal Strain in Asymptomatic Aortic Stenosis: A Systematic Review and Meta-Analysis
Authors: Wang Yuan , Zhang Minghui , Chen Hui , Li Hongwei 
Published: February 2022

BackgroundsThe presence of impaired global longitudinal strain (GLS) may be a valuable bio-marker in the early diagnosis for left ventricle (LV) impairment, which would help scrutinize asymptomatic aortic stenosis (AS) patients with high risk of adverse outcomes, such as major adverse cardiovascular events (MACE).MethodsThe study was prospectively registered in PROPSERO (CRD 42021223472). Databases, such as Pubmed, Embase, Cochrane Library, Web of science, and Scopus were searched for studies evaluating the impact of impaired GLS on MACE, all-cause mortality, and aortic valve replacement (AVR) in asymptomatic AS. Hazard ratios (HRs) with 95% CIs were calculated with meta-analysis for binary variants. Meta-regression, subgroup analysis, and sensitivity analyses were applied as needed to explore the heterogeneity.ResultsEventually, a total of nine studies reporting 1,512 patients were enrolled. Compared with the normal GLS group, impaired GLS significantly increased MACE (HR = 1.20, 95% CI: 1.10–1.30, I2 = 79%) with evident heterogeneity, all-cause mortality (HR = 1.42, 95% CI: 1.24–1.63), and AVR (HR = 1.17, 95% CI: 1.07–1.28). Subgroup analyses stratified by left ventricular ejection fraction (LVEF) &gt; 50% or LVEF without precise cut-off point found that compared with the normal GLS group, impaired GLS remarkably increased MACE both in two subgroups (LVEF &gt; 50%: HR: 1.22, 95% CI: 1.05–1.50; LVEF without cutpoint: HR: 1.25, 95% CI: 1.05–1.50). The results stratified by AS severity (mild/moderate and severe) or follow-up time resembled those stratified by LVEF. In addition, when subgroup analysis was stratified by mean aortic valve pressure gradient (MG ≥ 40 mm Hg and MG &lt;40 mm Hg), compared with normal GLS, impaired GLS significantly increased MACE both in two subgroups (MG ≥ 40 mm Hg: HR: 3.41, 95% CI: 1.64–7.09; MG below 40 mm Hg: HR: 3.17, 95% CI: 1.87–5.38). Moreover, the effect sizes here were substantially higher than those in the former two stratified factors.ConclusionsThe presence of impaired GLS substantially worsens the outcomes for adverse cardiovascular events in asymptomatic patients with AS regardless of LVEF or AS severity or follow-up time or mean aortic valve pressure gradient, which highlights the importance of incorporating impaired GLS into risk algorithms in asymptomatic AS.Systematic Review RegistrationPROSPERO (registration number: CRD42021223472).