bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymer Co‐Coating of Gold Nanoparticles Enables Their Integration Into Contact Lenses for Stable, Selective Ocular Light Filters
Authors: Clasky Aaron J. , Chen Paul Z. , Brooks William , McCabe Kevin , Gu Frank X. 
Published: October 2022

AbstractChronic exposure to long‐wavelength (red) light is associated with increased incidence and progression of myopia in preclinical models. Contact lenses are worn worldwide while chronic exposure to red light occurs, presenting a natural platform to mitigate light‐induced myopia progression. However, the integration of stable red‐light filters into contact lenses remains elusive. Here, bipyramidal gold nanoparticles (BPs) are synthesized as selective, tunable red‐light blockers and a surface‐modification method is developed to homogeneously embed them within contact lenses during manufacturing. By functionalizing the BPs with a combination of poly(vinylpyrrolidone) and methacrylate monomer, stable dispersions within etafilcon A contact lenses before, during, and after lens manufacturing are achieved. This approach enables the optical properties of hydrogel‐integrated nanoparticles to resemble their colloidal counterparts. Moreover, these BP‐laden contact lenses are stable against conditions relevant to manufacturing, sterilization, and use, including autoclaving, UV irradiation, and long‐term storage. Taken together, this work demonstrates selective light filters and a facile methodology to homogeneously embed functional nanoparticles into hydrogel biomaterials, such as contact lenses, potentiating a platform to mitigate myopia‐associated red‐light exposure.
Spray Coating of Nanosilicate‐Based Hydrogel on Concrete
Authors: Kim Won Hyeok , Han Youngbae , Rhie Yong Ha , Won Nam‐Il , Na Yang Ho 
Published: October 2022

AbstractHydrogels can be coated on various substrates to add a variety of functions to the substrates. In this study, hydrogel is coated on concrete that widely used as a building material. In general, in order to coat hydrogel on concrete, a prior process such as surface modification or primer layer coating is essential. However, this process is time consuming and requires the use of toxic chemicals. In this study, nanocomposite (NC) hydrogel that can be coated onto concrete in one step is used without any toxic chemicals. The spray‐coating method is adopted for continuous coating over a large area. An experimental device for spray coating is manufactured. Fast and uniform hydrogel coating on concrete is achieved. Various parameters of the spray‐coating process are optimized. Surface analysis on coated NC hydrogel is performed using a scanning electron microscope, atomic force microscope, and contact angle measurement. In order to confirm its applicability to green walls, an experiment is conducted to grow bryophyte on the NC hydrogel‐coated concrete. It is confirmed that bryophyte grows well on the NC hydrogel‐coated concrete. Concrete coated with NC hydrogel is expected to be a promising technology as a hydrogel‐based green wall system.
Silver Thin‐Film Electrodes Grown by Low‐Temperature Plasma‐Enhanced Spatial Atomic Layer Deposition at Atmospheric Pressure
Authors: Hasselmann Tim , Misimi Bujamin , Boysen Nils , Zanders David , Wree Jan‐Lucas , Rogalla Detlef , Haeger Tobias , Zimmermann Florian , Brinkmann Kai Oliver , Schädler Sebastian , Theirich Detlef , Heiderhoff Ralf , Devi Anjana , Riedl Thomas 
Published: October 2022

AbstractThe unique properties of atomic layer deposition (ALD) are mainly exploited for metal oxides, while the growth of metals, such as silver, is still in its infancy. Low growth temperatures and high growth rates are essential to achieve conductive (i.e. percolated) films. Here, a study based on the authors’ recently introduced N‐heterocyclic carbene‐based Ag amide precursor [(NHC)Ag(hmds)] (1,3‐di‐tert‐butyl‐imidazolin‐2‐ylidene silver(I) 1,1,1‐trimethyl‐N‐(trimethylsilyl) silanaminide) using plasma‐enhanced spatial ALD at atmospheric pressure and at deposition temperatures as low as 60 °C, is provided. The favorable reactivity and high volatility of the [(NHC)Ag(hmds)] precursor affords high growth rates up to 3.4 × 1014 Ag atoms cm–2 per cycle, which are ≈2.5 times higher than that found with the established triethylphosphine(6,6,7,7,8,8,8‐heptafluoro‐2,2‐dimethyl‐3,5‐octanedionate) silver(I) [Ag(fod)(PEt3)] precursor. Consequently, highly conductive Ag films with resistivities as low as 2.7 µΩ cm are achieved at a deposition temperature of 100 °C with a percolation threshold of ≈2.6 × 1017 Ag atoms cm–2, which is more than 1.6 times lower compared to [Ag(fod)(PEt3)]. As a concept study, conductive Ag layers are used as bottom electrodes in organic solar cells, that achieve the same performance as those based on Ag electrodes resulting from a high vacuum process.
Fabrication of a Periodic Inverse Micropyramid (PIMP)‐Si/In2Se3 Heterojunction Photodetector Array for RGB‐IR Image Sensing Application
Authors: Zhang Chao , Zhu Chen‐Yue , Yang Zhen , Lin Di‐Hua , Wu Chun‐Yan , Chen Shi‐Rong , Yang Yi‐Zhong , Wang Li , Zhou Yu‐Xue , Luo Lin‐Bao 
Published: October 2022

AbstractHere, the fabrication of an addressable 8 × 8 photodetector array is reported by combining In2Se3 nanofilm with periodic inverse micropyramid‐Si (PIMP‐Si), which is obtained through colloidal lithography and anisotropic wet etching. Due to the unique configuration and the outstanding light trapping effect, the as‐fabricated heterojunction device presents an excellent self‐powered photoresponse over the broadband wavelength range from 265 to 1300 nm, with a peak sensitivity at ≈810 nm. The responsivity, specific detectivity, and rise/fall time are estimated to be 0.58 A W−1, 1.76 × 1012 Jones, and 5.1/18 µs, respectively, which are competitive in comparison with other devices with similar geometries. Meanwhile, the photodetector array displays a satisfactory pixel‐to‐pixel uniformity, which allows the device to record the full‐color image of “HFUT” with satisfying resolution, revealing the potential application of the PIMP‐Si/In2Se3 heterojunction photodetector array for real‐time red‐green‐blue‐infrared image sensing and video capturing.
The Endoplasmic Reticulum ATP13A1 is Essential for MAVS‐Mediated Antiviral Innate Immunity
Authors: Zhang Rui , Hou Xianteng , Wang Changwan , Li Jiaxin , Zhu Junyan , Jiang Yingbo , Hou Fajian 
Published: October 2022

AbstractRIG‐I‐MAVS signaling pathway is essential for efficient innate immune response against virus infection. Though many components have been identified in RIG‐I pathway and it can be partially reconstituted in vitro, detailed mechanisms involved in cells are still unclear. Here, a genome‐wide CRISPR‐Cas9 screen is performed using an engineered cell line IFNB‐P2A‐GSDMD‐N, and ATP13A1, a putative dislocase located on the endoplasmic reticulum, is identified as an important regulator of RIG‐I pathway. ATP13A1 deficiency abolishes RIG‐I‐mediated antiviral innate immune response due to compromised MAVS stability and crippled signaling potency of residual MAVS. Moreover, it is discovered that MAVS is subject to protease‐mediated degradation in the absence of ATP13A1. As homozygous Atp13a1 knockout mice result in developmental retardation and embryonic lethality, Atp13a1 conditional knockout mice are generated. Myeloid‐specific Atp13a1‐deficient mice are viable and susceptible to RNA virus infection. Collectively, the findings reveal that ATP13A1 is indispensable for the stability and activation of MAVS and a proper antiviral innate immune response.
Prospective Sustainability Screening of Sodium‐Ion Battery Cathode Materials
Authors: Baumann Manuel , Häringer Marcel , Schmidt Marius , Schneider Luca , Peters Jens F. , Bauer Werner , Binder Joachim R. , Weil Marcel 
Published: October 2022

AbstractSodium‐ion batteries (SIB) are considered as a promising alternative to overcome existing sustainability challenges related to Lithium‐ion batteries (LIB), such as the use of critical and expensive materials with high environmental impacts. In contrast to established LIBs, SIBs are an emerging technology in an early stage of development where a challenge is to identify the most promising and sustainable cathode active materials (CAM) for further research and potential commercialization. Thus, a comprehensive and flexible CAM screening method is developed, providing a fast and comprehensive overview of potential sustainability hotspots for supporting cathode material selection. 42 different SIB cathodes are screened and benchmarked against eight state‐of‐the‐art LIB‐cathodes. Potential impacts are quantified for the following categories: i) Cost as ten‐year average; ii) Criticality, based on existing raw material criticality indicators, and iii) the life cycle carbon footprint. The results reveal that energy density is one of the most important factors in all three categories, determining the overall material demand. Most SIB CAM shows a very promising performance, obtaining better results than the LIB benchmark. Especially the Prussian Blue derivatives and the manganese‐based layered oxides seem to be interesting candidates under the given prospective screening framework.
Importance of triple tumor markers as biomarkers in patients with pancreatic ductal adenocarcinoma
Authors: Takagi Tadataka , Nagai Minako , Nishiwada Satoshi , Terai Taichi , Yasuda Satoshi , Matsuo Yasuko , Doi Shunsuke , Kohara Yuichiro , Sho Masayuki 
Published: October 2022

AbstractAimThere is an urgent need to establish biomarkers for the treatment of pancreatic ductal adenocarcinoma (PDAC). The aim of this study was to investigate the usefulness of the combined assessment of carbohydrate antigen 19‐9 (CA19‐9), carcinoembryonic antigen (CEA), and duke pancreatic monoclonal antigen type 2 (DUPAN‐2) in PDAC.MethodsWe retrospectively investigated the impact of three tumor markers on overall survival (OS) and recurrence‐free survival (RFS). Patients were classified into two groups: upfront surgery (US) and neoadjuvant chemoradiation (NACRT) groups.ResultsIn total, 310 patients were evaluated. In the US group, patients who had all three elevated markers showed a significantly worse prognosis than the others (median: 16.4 months, P = .005). In the NACRT group, patients who had elevated CA 19‐9 and CEA levels after NACRT had significantly worse prognosis than the others (median: 26.2 months, P < .001). The elevated DUPAN‐2 levels before NACRT were associated with significantly worse prognosis than normal levels (median: 44.0 vs 59.2 months, P = .030). Patients who had elevated DUPAN‐2 levels before NACRT with elevated CA 19‐9 and CEA levels after NACRT showed extremely poor RFS (median: 5.9 months). Multivariate analysis revealed that a modified triple‐positive tumor marker indicating elevated DUPAN‐2 levels before NACRT and elevated CA19‐9 and CEA levels after NACRT was an independent prognostic factor of OS (hazard ratio: 2.49, P = .007) and RFS (hazard ration: 2.47, P = .007).ConclusionsThe combined evaluation of three tumor markers may provide useful information for the treatment of patients with PDAC.
Patient characteristics that predict Richter's transformation in patients with chronic lymphocytic leukemia treated with ibrutinib
Authors: Kittai Adam S. , Huang Ying , Beckwith Kyle A. , Bhat Seema A. , Bond David A. , Byrd John C. , Goldstein Daniel , Grever Michael R. , Miller Cecelia , Rogers Kerry A. , Yano Max , Woyach Jennifer A. 
Published: October 2022

Abstract
Chronic lymphocytic leukemia (CLL) transformation to aggressive lymphoma, known as Richter's Transformation (RT), has a dismal prognosis. There are limited data evaluating risk of RT in patients treated with ibrutinib. We performed a retrospective analysis to determine prognostic variables associated with development of RT and overall survival (OS) at progression after treatment with ibrutinib. We identified 559 patients with CLL treated with ibrutinib from 2010–2019. After a median follow‐up of 44.5 months from ibrutinib start, 179 patients progressed and were included in our analysis. After a median follow‐up of 20.8 months from progression, 54 out of 179 patients developed RT. Progression on treatment (hazard ratio [HR] 4.01 [1.60–10.00], p = .003), higher LDH (HR 1.80 for 2‐fold increase [1.33–2.43], p = .0001), and lymphadenopathy without lymphocytosis (HR 2.88 [1.15–7.20], p = .02) were independent prognostic variables for the development of RT at progression. Progression with lymphadenopathy without lymphocytosis continued to be an independent prognostic variable of worse OS post‐progression. In a subset analysis of 50 patients who obtained a PET‐CT at progression, the median SUVmax for patients who would develop RT was 15.2 (n = 30, range: 4.0–46.3) versus those patients who did not develop RT with a SUVmax of 7.7 (n = 20, range: 2.3–27.2) (p = .0030). Median OS from date of RT was 4.0 months, suggesting that prognosis for RT remains poor. A lymph node biopsy to rule out RT should be considered in patients who received ibrutinib who progress on treatment, have an elevated LDH, or progress with lymphadenopathy without lymphocytosis.
Synthesis of Difluoromethyl Pyrazolines and Pyrazoles by [3+2] Cycloaddition Reaction of Difluoroacetohydrazonoyl Bromides with Electron‐deficient Olefins
Authors: Ren Yuanyuan , Ma Ransong , Feng Yang , Wang Ke‐Hu , Wang Junjiao , Huang Danfeng , Lv Xiaobo , Hu Yulai 
Published: October 2022

AbstractDifluoroacetohydrazonoyl bromides, which are stable in air at room temperature, are demonstrated to be good difluoromethyl building blocks for construction of CF2H‐substituted pyrazoline and pyrazole compounds via [3+2] cycloaddition with electron‐deficient olefins under mild conditions. A series of CF2H‐substituted pyrazolines and pyrazoles were obtained in good yields. The method has the advantages of mild reaction conditions, good regioselectivity, broad substrate scopes and easy operation.
Collective Syntheses of Eight Phorbaketals via Total Synthesis of Phorbaketal A
Authors: Lee Jaeyeon , Joung Seewon , Lee Hee‐Yoon 
Published: October 2022

AbstractA practical total synthesis of phorbaketal A, a representative natural product among spiroketal containing natural products from marine sponge Phorbas sp. that has been a productive source of structurally diverse terpene natural products with various biological activities was achieved through gold‐catalyzed spiroketalization of the alkynediol precursor accompanied by the epoxide rearrangement to the corresponding allylic alcohol followed by an olefin isomerization. With the solid pathway to produce phorbaketal A in hand, we achieved collective synthesis of eight phorbaketals as they appeared to be derived from phorbaketal A in nature.
Donepezil treatment is associated with improved outcomes in critically ill dementia patients via a reduction in delirium
Authors: Lieberman Ori J. , Lee Seonjoo , Zabinski Jeffrey 
Published: October 2022

AbstractIntroductionDuring hospital admissions, patients with dementia are at risk for developing delirium, an acute state of brain failure associated with significant morbidity. There are currently no pharmacologic tools to treat or prevent delirium. Decreased cholinergic signaling plays a role in the pathophysiology of both disorders. Whether enhanced pre‐hospital cholinergic signaling in patients with dementia improves outcomes during critical illness remains unknown.MethodsWe utilized the Medical Information Mart for Intensive Care III (MIMIC‐III) database to determine whether pre‐hospital donepezil use was associated with improved outcomes during critical illness in dementia patients.ResultsWe identified 2734 subjects with dementia admitted to the intensive care unit (ICU; 447 received donepezil). After adjusting for confounders, patients with dementia who were receiving donepezil had a significantly reduced in‐hospital and 90‐day mortality, ICU length of stay, and duration of mechanical ventilation. Donepezil use was associated with, and its benefit was mediated by, reduced delirium.DiscussionPatients with dementia who are treated with donepezil have improved outcomes during critical illness and reductions in delirium.Highlights
No pharmacologic treatments exist to reduce delirium in patients with dementia.
Donepezil improves outcomes during critical illness in patients with dementia.
Improved outcomes are mediated by a reduction in hospital delirium.
Future studies in patients with dementia should prospectively evaluate donepezil in the prevention of delirium.
Highly reactive adsorbent based on carboxymethyl xanthan gum‐g‐poly(4‐vinylpyridine) copolymer for the potential removal of Acid Orange 10 dye and Cr(VI) ions for water treatment
Authors: Elgamal Ahmed M. , Abd El‐Ghany Nahed A. , Saad Gamal R. 
Published: October 2022

AbstractThe removal efficiency of an anionic acid dye, Acid Orange 10 dye (AO‐10), and hexavalent chromium metal Cr(VI) from an aqueous medium using carboxymethyl xanthan gum‐g‐poly(4‐vinyl pyridine), CMX‐g‐P(4VP), as a novel adsorbent was studied. The influences of pH, adsorbent dose, temperature, and equilibrium time on the adsorption process were evaluated to optimize the conditions for maximum removal of the adsorbate. Both AO‐10 and Cr(VI) removal were pH‐dependent, with the most excellent adsorption capacity occurring at pH 2.5. AO‐10 and Cr(VI) had maximum adsorption capacities of 1961 and 492 mg g−1, respectively, considerably high. The adsorbent may be efficiently reused for five cycles, according to the desorption studies. The experimental adsorption equilibrium data were described using the Langmuir, Freundlich and Dubinin‐Radushkevich isotherm models. The Langmuir is judged the closest to the description of the practical. In addition, the kinetics of the adsorption process is controlled using pseudo‐first‐order and intraparticle diffusion kinetic models, while the thermodynamic process proved the spontaneous and exothermic nature of removing AO‐10 and Cr(VI) ions. Overall, the results showed that CMX‐g‐P(4VP) might be a very efficient re‐usable adsorbent in wastewater treatment.
Development of PLA/EPDM/SiO2 blended polymer for biodegradable packaging
Authors: Wittawat Ratanathavorn , Rittipun Rungruang , Nattaporn Boohuad 
Published: October 2022

AbstractHerein, we developed a blended polymer of polylactic acid (PLA) and ethylene propylene diene (EPDM) for cosmetic packaging using dihydrogenated tallow‐treated nanosilica to improve the compatibility between PLA and EPDM, which are immiscible. The PLA/EPDM ratio was maintained at 95/5, and the loading rates of the modified nanosilica powder were set at 0, 3, and 5 phr. Fourier‐transform infrared spectroscopy demonstrated that the nanosilica particles adsorbed the cationic surfactant solution onto their surfaces. Scanning electron microscopy showed that the EPDM domain sizes within the PLA matrix reduced with increasing modified nanosilica amounts. Moreover, the modified nanosilica improved the compatibility between the PLA and EPDM phases. The tensile strength and elongation at break of the PLA/EPDM/SiO2 (95/5/5) polymer were 50.39 MPa and 32.8%, respectively. The degradation behavior of the polymer in water and a sodium lauryl ether sulfate (SLES) solution was evaluated. The decomposition rate of the polymer was higher in SLES with low polarity and was determined to be approximately 3.4 × 10−8 s−1. Moreover, during a disintegration test (ISO 16929:2019), the polymer exhibited a disintegration rate of 100%, degrading completely in 28 days.
Measurements of visual double stars with PISCO2 at the Nice 76‐cm refractor in 2013–2014
Authors: Gili René , Prieur Jean‐Louis , Rivet Jean‐Pierre , Vakili Farrokh , Scardia Marco , Pansecchi Luigi , Argyle Robert W. , Ling Josefina F. , Piccotti Luca , Aristidi Eric , Koechlin Laurent , Bonneau Daniel , Maccarini Luca , Serot Jocelyn 
Published: October 2022

AbstractWe present relative astrometric and photometric measurements of visual double stars made in 2013–2014 with PISCO2 installed at the 76‐cm refractor of the Côte d'Azur Observatory in Nice (France). Our observation list contains orbital couples as well as double stars whose motion is still uncertain. Three different techniques were used for obtaining measurements: Lucky Imaging, Speckle Interferometry, and the Direct Vector Autocorrelation method. From our observations of 4,864 multiple stars, we obtained 4,952 new measurements with angular separations in the range 0″.1–14″ and an average accuracy of 0″.015. The mean error on the position angles is 1°.0. Most of the position angles were determined without the usual 180° ambiguity with the application of the direct vector autocorrelation technique and/or by inspection of the Lucky images or the long integration files. We managed to routinely monitor faint systems (mV ≈ 9–11) with large magnitude differences (up to ΔmV ≈ 5). We have thus been able to measure 49 systems containing red dwarf stars that had been poorly monitored since their discovery, from which we estimated the stellar masses thanks to Gaia measurements. We also measured the magnitude difference of the two components of 318 double stars with an estimated error of 0.2 mag. Except for a few objects that have been discussed, our measurements are in good agreement with the ephemerides computed with published orbital elements, even for the double stars whose separation is smaller than the diffraction limit. Thanks to good seeing images and with the use of high‐contrast numerical filters, we have also been able to obtain 455 measurements with an angular separation smaller than the diffraction limit of our instrumentation, and consistent with those obtained with larger telescopes. Finally, we report 378 measurements of the 296 new double stars that we found in the files obtained during the observations.
COVID‐19 modifications to a first year medical human anatomy course: Effects on student performance on summative examinations
Authors: McNamara John Patrick , Nolan Michael F. 
Published: October 2022

AbstractThe COVID‐19 (COVID) pandemic forced changes in how medical curricula are organized and delivered. In addition to disease mitigation strategies, other curricular modifications were required to maintain educational effectiveness and student and faculty safety. While these changes appear to be successful in their primary goal, their effect on learning and other important educational outcomes is less well understood. We describe changes to our anatomy course and describe their effects on summative examination scores. We compared anatomy examination scores from 4 years prior to COVID with scores from the 2 years following COVID mandated changes in an effort to determine the effectiveness of our course modifications. Examination scores for the first of four successive Blocks of instruction following the implementation of curricular changes demonstrated a lower mean score and greater range of scores than for the four pre‐COVID years. Pre‐COVID and post‐COVID scores for Blocks II, III, and IV were comparable. Our results indicate that our changes to the anatomy curriculum did not prevent a performance decline during the first Block of instruction only. However, students were able to successfully adapt to these changes during the remainder of the course. We discuss factors that may have accounted for the Block I performance decline and call attention to changes within the larger curriculum that may have affected student performance.