bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Media Karikatur Berbasis Kearifan Lokal Kediri bagi Siswa Sekolah Dasar
Authors: Daryanti Eka Wahyu , Laila Alfi , Saidah Karimatus 
Published: July 2022

Tujuan dari penelitian ini untuk : (1) Mengetahui kevalidan media karikatur berbasis kearifan lokal Kediri bagi siswa SD. (2) Mengetahui keefektivan media karikatur berbasis kearifan lokal Kediri bagi siswa SD. Penelitian berikut menggunakan R & D yang meliputi lima tahap yaitu analisis, desain, pengembangan, implementasi, dan evaluasi. Teknik pengumpulan data dengan angket validasi ahli media, ahli materi, serta uji terbatas dan luas. Teknik dari analisis data menggunakan uji Kevalidan dan keefektivan Sugiyono (2012). Perolehan dari penelitian sebagai berikut. 1) Media karikatur berbasis kearifan lokal Kediri memperoleh skor kevalidan dari ahli media 90% dan 92% untuk ahli materi. 2) Media karikatur berbasis kearifan lokal Kediri masuk dalam ketegori sangat efektif, dibuktikan dari nilai pre-test 59,95 dan post-test 79,1. Hasil uji homogenitas terbatas dan luas 0.049 > 0.005 dan 0.948> 0.005 (data homogen), uji normalitas terbatas dan luas yaitu 0.200 > 0.005 (data normal), uji paired T-test terbatas dan luas 0.007< 0.05 dan 0.000< 0.05 jadi adanya pengaruh signifikan antara pre-test dan post-test. Hasil penelitian sangat diperlukan sebagai landasan pengembangan pembelajaran bahasa Indonesia di SD.
Pengaruh Keberagaman Produk Dan Persepsi Harga Terhadap Keputusan Pembelian Sepeda Ontel Di Toko Agung Jombang
Authors: Asnawi  , Moch Heru Widodo  , Stevanus Gatot Supriyadi  
Published: July 2022

Abstract
Tujuan penelitian ini untuk mengetahui pengaruh keberagaman produk dan persepsi harga terhadap keputusan pembelian sepeda ontel di toko Agung Jombang. Penelitian ini menggunakan metode explanatory research dan analisis yang digunakan adalah regresi linear berganda. Teknik pengambilan sampel pada penelitian ini menggunakan accidental sampling. Didapat sampel sebanyak 100 responden dimana pengumpulan menggunakan kuisioner. Teknik analisis data pada penelitian ini menggunakan uji vaiditas, reliabiltas dengan alpha cronbach, asumsi klasikregresi sederhana dan uji t. Dari hasil analisis data diperoleh nilai t hitung sebesar 0,084 < 1,66 tabel. Hal ini berarti terdapat pengaruh yang signifikan antara variabel keberagam produk dan persepsi harga terhadap keputusan pembelian.
Studi Tentang Candi Ngetos Di Kabupaten Nganjuk Ditinjau Dari Kajian Ikonografi
Authors: Yatmin  , Zainal Afandi  
Published: July 2022

Di Indonesia banyak sekali Peninggalan-peninggalan bersejarah yang memiliki nilai yang adi luhung yang sangat luar biasa, Candi merupakan hasil budaya bangsa yang tinggi nilainya. Keberadaan sebuah Candi banyak yang belum dikenal masyarakat luas. Kondisi yang demikian disebabkan oleh kurangnya sumber-sumber tertulis tentang sejarah bangunan Candi tersebut. Kita semua tentunya menyadari, bahwa bangunan Candi merupakan aset bangsa yang sangat potensial di berbagai aspek pembangunan. Salah satu Candi yang belum dikenal masyarakat luas yaitu Candi Ngetos. Penulis sengaja mengangkat Candi Ngetos sebagai Objek penelitian yang tujuannya ingin mempelajari dan mengungkap keberadaan Candi Ngetos di Desa Ngetos, kecamatan Ngetos, Kabupaten Nganjuk. Wilayah Ngetos memang cocok sekali untuk sebuah bangunan suci yang monumental yaitu berada di daerah pegunungan, serta memungkinkan untuk pengembangan daerah obyek wisata kabupaten Nganjuk. Hasil kebudayaan jaman Majapahit ini ternyata juga pernah diteliti oleh pemerintah Hindia Belanda dibawah pimpinan Gubernur Jendral Thomas Stanford Raffles sejak tahun 1817. Adapun bangunan candi Ngetos sebagai hasil budaya masa Majapahit ini berfungsi sebagai tempat pemujaan roh leluhur dan pemujaan para dewa.
Implementasi Algoritma Haversine Formula Pada Aplikasi Sadewa (Sistem Informasi Destinasi Wisata) Kota Salatiga Berbasis Android
Authors: Rohmatulloh Yusuf Ma'iin , Herlambang Bambang Agus , Wibowo Setyoningsih 
Published: July 2022

Abstract - Salatiga is a city in Central Java Province which is located in the middle of two big cities, namely Semarang City which are 49 km away and Surakarta City which is 52 km away. During the colonialism, the Dutch government dubbed Salatiga as "De Schoonste Stad van Midderi-Javaborder" or the most beautiful city in Central Java. At this time the government of Salatiga City is working to make Salatiga again the most beautiful city in Central Java by making development efforts to beautify the city. To support this program, an information technology is needed to improve information about tourism. Tourists who will visit to need information on the nearest tourist destination to plan a trip to a tourist destination. The search for the nearest location can be applied using one of the algorithms, namely the Haversine Formula algorithm. This study uses Google Maps to display location routes. In terms of a utilization, it is hoped that this information system can make it easier for tourists to visit tourist destinations in Salatiga City.
Evaluation of the Efficacy and Safety of Initial Empirical Antibiotic Therapy for Community-Acquired Pneumonia in Middle-Aged People
Authors: Alexandrova T. V. , Muslimova O. V. , Zhuravleva M. V. , Alexandrov A. A. , Gorodetskaya G. I. , Demchenkova E. Yu. , Demidova O. A. , Sokova E. A. , Mazerkina I. A. , Smirnova Yu. А. 
Published: July 2022

β-lactam antibiotics, including cephalosporins, are the drugs of choice for empirical antibiotic therapy (ABT) in patients with community-acquired pneumonia. Unreasonable and irrational use of antibiotics leads to an increased risk of adverse reactions, contributes to the growth of antibiotic resistance.The aim of the study was to analyse data on the efficacy and safety of initial empirical ABT using cephalosporins for community-acquired pneumonia in middle-aged patients of multidisciplinary hospitals in Moscow.Materials and methods: the authors analysed 177 archived medical records of the patients admitted to three multidisciplinary hospitals (I.V. Davydovsky City Clinical Hospital, City Clinical Hospital 52 and City Clinical Hospital 4) in Moscow from 2017 to 2019 and prescribed mono- and/or combination therapy including a cephalosporin antibiotic as a starting therapy for community-acquired pneumonia. The initial ABT was considered effective if a patient’s body temperature normalised within 48–72 h following initiation of treatment and safe if no adverse reactions developed during the period of inpatient treatment.Results: the combination of ceftriaxone and azithromycin was the most frequently prescribed ABT regimen; its effectiveness was 71.9%. Ceftriaxone monotherapy was the second in frequency of prescription; its effectiveness amounted to 77.2%. The third regimen included cefotaxime and azithromycin and was effective in 70% of cases. The patients who needed a change in initial ABT had a significantly higher incidence of developing severe community-acquired pneumonia and complications. The study results indicate that the structure of comorbidity did not affect the effectiveness of initial empirical ABT. Streptococcus pneumoniae was found to be the most common causative agent of community-acquired pneumonia in the studied population (44.8% of cases). Only 13% of the patients faced adverse reactions associated with the use of antibiotics as part of the initial empirical ABT; the most common were leukopenia and diarrhoea.Сonclusions: the results of the study indicate the feasibility of mono- and/or combination ABT including a cephalosporin antibiotic as a starting empirical therapy for community-acquired pneumonia due to its effectiveness and favourable safety profile.
Therapeutic Drug Monitoring for Evaluation of the Efficacy and Safety of Vancomycin in Patients with Orthopaedic Infections
Authors: Tufanova O. S. , Kasimova A. R. , Bozhkova S. A. 
Published: July 2022

Vancomycin is a drug of choice for the infections caused by methicillin-resistant strains of staphylococci. Its use requires individualised dosing and renal function monitoring.The aim of the study was to evaluate, using therapeutic drug monitoring (TDM), the frequency of reaching target trough serum concentrations (TSCs) and the frequency of renal function impairment in orthopaedic infection patients receiving vancomycin therapy.Materials and methods: the authors carried out a retrospective analysis of vancomycin TSC test results of 457 patients admitted to a purulent osteology department in 2019–2021. The results were grouped according to the number of TSC determination performed as part of TDM (tests 1, 2, and 3). Each of the 3 groups was further divided into 4 subgroups according to the TSCs of vancomycin: ≤9.9 µg/ml (extremely low), 10–14.9 µg/ml (recommended for mild infections), 15–19.9 µg/ml (recommended for bone and joint infections), ≥20 µg/ml (potentially toxic). The results obtained in each group were analysed separately.Results: according to the 1st TDM test, only 9.6% of patients achieved the TSCs of vancomycin recommended for bone and joint infections. Extremely low TSCs, insufficient for treatment of the infections, were found in 64.8% of patients. According to the 2nd and 3rd TSC determinations, dose corrections decreased the percentage of patients with extremely low TSCs to 49.9% and 41.2%, respectively. Potentially toxic TSCs of vancomycin were detected in 48 (10.5%) patients, but renal dysfunction was observed only in 8 (1.75%) of them. The authors exemplify the use of TDM to control the efficacy and safety of vancomycin in patients with pronounced signs of renal function impairment by two clinical cases.Conclusion: with a standard dose of vancomycin, the concentrations recommended for bone and joint infections were reached only in every tenth patient. There was a large percentage of patients with extremely low serum concentrations of the medicinal product (64.8%), but it decreased after dose adjustments. Monitoring of vancomycin concentrations allows for individualised dosing, efficacy control and significant reduction of the risk of adverse kidney reactions.
Experience of Using Therapeutic Drug Monitoring to Control the Safety of Vancomycin in Intensive Care Unit Patients with Sepsis
Authors: Prokofiev A. B. , Belkov S. A. , Kazakov R. E. , Berdnikova N. G. , Rodina T. A. , Melnikov E. S. , Danko A. A. , Voronova N. E. , Vafina R. Z. , Zavtoniev A. V. , Tsyganko D. V. , Demchenkova E. Yu. 
Published: July 2022

Vancomycin is prescribed to patients in serious condition with infections caused by Gram-positive microorganisms; however, if the therapeutic plasma concentration of the medicinal product is exceeded, it can have a nephrotoxic effect.The aim of the study was to demonstrate the possibility of using therapeutic drug monitoring (TDM) to reduce the risk of developing nephropathy in intensive care unit patients with sepsis.Materials and methods: the study comprised a retrospective analysis of four clinical cases of patients with sepsis admitted to intensive care units of I.V. Davydovsky City Clinical Hospital in 2021 and treated with vancomycin. TDM of vancomycin plasma levels was performed by reverse-phase high-performance liquid chromatography with mass spectrometric detection.Results: using the four cases of septic patients, the study demonstrated that vancomycin at adequate case-specific doses may result in plasma concentrations beyond the therapeutic range. TDM of vancomycin concentrations helped to prevent further deterioration of renal dysfunction in one septic patient having developed acute kidney injury and to control the achievement of therapeutic vancomycin concentrations or timely adjust the dose to that effect in the other three cases.Conclusions: a timely correction of vancomycin dosing with plasma TDM allows for achieving high antimicrobial efficacy in patients with sepsis and minimising the nephrotoxic effect of the medicinal product. Studies of the feasibility of using TDM as a treatment personalisation tool for patients in serious condition will continue in the future.
Efficacy and Safety of Ascites Treatment in Liver Cirrhosis
Authors: Ignatenko G. A. , Kugler T. E. , Taradin G. G. , Rakitskaya I. V. , Kaluga A. A. 
Published: July 2022

Cirrhosis is one of the major health problems worldwide; and ascites is often its first and foremost manifestation. Despite the advances in modern hepatology, the presence of ascites is associated with a poor prognosis and high mortality. The aim of the study was to analyse data on the efficacy and safety of ascites treatment options, taking into account the pathophysiology of the condition. The analysis of literature and international guidelines on ascites management showed that cirrhotic ascites is treated with medication or surgery that interfere with pathogenetic mechanisms underlying the condition. Treatment of uncomplicated ascites depends on the severity of clinical manifestations. Patients with grade 1 ascites do not require treatment. Therapy for grade 2–3 ascites is aimed at reducing sodium intake and promoting its excretion with diuretics. The effect of diuretics should be assessed by daily monitoring of body weight. Close monitoring of serum creatinine and electrolyte levels is necessary to avoid severe electrolyte imbalance and mitigate the risk of diuretic-associated acute kidney injury. Another medical option to increase diuresis is the use of vasoconstrictors. Large volume paracentesis is the treatment of choice for patients with grade 3 ascites and refractory ascites. The most dangerous complication of paracentesis is circulatory dysfunction, which is prevented by limiting the volume of fluid removed to 5–6 liters per procedure and using plasma substitutes. If paracentesis is ineffective, new minimally invasive methods of treatment should be considered: transjugular intrahepatic portosystemic shunting and automated low-flow ascitic fluid removal system. However, given the poor prognosis, all patients with refractory ascites should be considered candidates for liver transplantation, which is currently the only effective treatment. The efficacy and safety of therapy may be enhanced by a personalised approach to choosing the treatment for ascites in cirrhosis, as well as further investigation of means to mitigate adverse reactions to medication and minimally invasive surgery.
PERLINDUNGAN HUKUM KORBAN INVESTASI BINARY OPTIOM BERKEDOK TRADING
Authors: H Ferrario M 
Published: July 2022

Pandemi COVID-19 telah menghancurkan roda perekonomiam, berbagai lapisan masyarakat terkena dampak dari pandemic ini, akibat dari pandemic ini roda perekonomian masyarakat menjadi tidak stabil. Masyarakat Indonesia mulai mencari cara dalam mengelola keuangan dengan lebih baik agar dapat bertahan dalam situasi pandemi ini, salah satu caranya dengan berinvestasi. Binary Option Trading menjadi hal yang cukup banyak dibicarakan publik belakangan ini, dikarenakan banyak influencer dan iklan-iklan bertebaran mengenai keuntungan besar yang bisa didapatkan melalui Binary Option Trading. dalam Peraturan Bappebti No. 3 Tahun 2019 tentang Komoditi, Binary option tidak termasuk dalam subjek yang tertulis di Pasal 1. Hal ini secara tidak langsung dapat diartikan bahwa Binary Option ilegal.
KEABSAHAN PERJANJIAN PINJAM NAMA (NOMINEE) DALAM PERJANJIAN PINJAMAN UANG DI INDONESIA
Authors: Wardhana Tri Aji Nur Dewa Kusuma 
Published: July 2022

Perjanjian pinjam nama (nominee) adalah perjanjian yang belum ada pengaturannya secara khusus dalam Kitab Undang-Undang Hukum Perdata (KUHPerdata), tetapi tumbuh dan berkembang dimasyarakat. Perjanjian pinjam nama ini masuk ke dalam perjanjian khusus atau sering disebut perjanjian inominaat. Penelitian ini dilatarbelakangi dan dilakukan dengan tujuan mendeskripsikan pengaturan perjanjian pinjam nama(nominee) sebagai bentuk perjanjian dalam pinjaman uang yang telah berkembang dan dilakukan masyarakat saat ini. Metode penelitian menggunakan penelitian hukum normatif. Berdasarkan temuan penelitian diketahui bahwa tidak tersedianya aturan secara khusus untuk perjanjian pinjam nama yang diatur dalam undang-undang (KUHPerdata). Selama para pihak bisa menjalankan perjanjian dengan baik sesuai ketentuan Undang-Undang tentang sahnya perjanjian dan mengenai perjanjian pinjaman yang sudah diatur di dalam KUHPerdata, perjanjian tersebut bisa dikatakan sah di mata hukum jika telah sesuai dengan syarat perjanjian dalam KUHPerdata
PERLINDUNGAN HUKUM TERHADAP PHK IPEKERJA SEPIHAK AKIBAT GUGATAN INDUSTRIAL YANG MASIH DALAM PROSES
Authors: Zein Mochamad Adam Fahreza 
Published: July 2022

Perlindungan dan jaminan kepastian hukum Ketenagakerjaan mulai mendapatkan tempat setelah keluarnya Undang-undang No 13 Tahun 2003 tentang Ketenagakerjaan dimana posisi Pekerja/buruh dan Pengusaha/Perusahaan mendapatkan posisi yang seimbang, Mekanisme penyelesaian perselisihan hubungan industrial yang diatur Undang-Undang Nomor 2 Tahun 2004 seakan menjadi kontradiktif ketika putusan batal demi hukum dengan kewajiban pengusaha untuk mempekerjakan kembali pekerja yang telah dilakukan PHK sepihak banyak tidak dilaksanakan pengusaha termasuk putusan yang dikeluarkan oleh pengadilan sekalipun. Pemutusan Hubungan Kerja (PHK) dapat dilakukan jika dilakukan tidak dengan cara sepihak dan merugikan para pekerja/buruh. Perlindungan hukum mengenai Pemutusan Hubungan Kerja (PHK) secara sepihak telah diatur dalam Pasal 153 Undang-Undang Cipta Kerja,yang dimana dalam pemutusan hubungan kerja pengusaha memiliki larangan untuk melakukan pemutusan hubungan kerja (PHK). Pemutusan Hubungan Kerja (PHK) secara sepihak sangat tidak diperbolehkan
The prediction of pKa values for phenolic compounds by the DFT theory
Authors: Nguyen Nguyen Thi My, Nguyen Van Din, Mai Van Bay 
Published: July 2022

The acid dissociation constant is an important parameter that affects the physicochemical properties of molecules in solution. A set of 20 phenolic compounds were used to establish a model to predict values of phenolic compounds. Calculations in aqueous medium were performed with a polarizable continuum solvent model (PCM) and three hybrid DFT functionals (B3LYP, PBE0, ωB97XD and M062X) with the basis set 6-311++G(d,p). The directly calculated value of gives less accurate results with an average absolute error (MAE) of 1.74 units when using the ωB97XD functional and phenol as reference compound. In the case of using statistical correction, the accuracy of is greatly improved. In the case of using statistical correction, the accuracy of is greatly improved with the lowest MAE value of 0.14 units (M062X; ). The calculated results of in this study have the same accuracy as the experimental measurements.The acid dissociation constant is an important parameter that affects the physicochemical properties of molecules in solution. A set of 20 phenolic compounds were used to establish a model to predict values of phenolic compounds. Calculations in aqueous medium were performed with a polarizable continuum solvent model (PCM) and three hybrid DFT functionals (B3LYP, PBE0, ωB97XD and M062X) with the basis set 6-311++G(d,p). The directly calculated value of gives less accurate results with an average absolute error (MAE) of 1.74 units when using the ωB97XD functional and phenol as reference compound. In the case of using statistical correction, the accuracy of is greatly improved. In the case of using statistical correction, the accuracy of is greatly improved with the lowest MAE value of 0.14 units (M062X; ). The calculated results of in this study have the same accuracy as the experimental measurements.
The moderating role of perceived CSR messages on the relationship between e-WOM and online customer trust
Authors: Nguyen Nguyen Hong Quan , Pham Pham Lan Huong , Pham Pham Thai Ha , Tran Tran Hong Ha , Ha Ha Minh Ngoc , Le Le Thi Hong Loan 
Published: July 2022

Electronic word of mouth (e-WOM) studies have been popular as a result of the rise of social networks and e-commerce. Nonetheless, there has been very little research on CSR communication associated with e-WOM. The purpose of this study is to see how e-WOM, as a means of sharing information about CSR activities, affects Vietnamese B2C e-commerce customers’ trust. With the help of 349 online consumers in Hanoi, data was gathered through online and direct survey methods. As a result of the findings, we can conclude that the relationship between e-WOM and customer’s trust is moderated by CSR messages. The authors provide a variety of solutions based on the research findings to assist B2C organizations in improving their communicating information about CSR activities to achieve the optimum marketing effectiveness
INVESTIGACION Y DESARROLLO Diciembre 2020
Authors: Valdez Duffau(PhD) Mathias , Aldas(Mg) Darwin , Hidalgo(Mg) Cynthia , Andrade (Ing) Alexandra , Peñaherrera(Dr) Patricio 
Published: July 2022

Resumen

John Paúl Reyes Vasquez (Mg), Director de Investigación y Desarollo, UTA
Mathias Exequiel Valdez Duffau(PhD), Editor - Revista Investigación y Desarrollo, UTA
Yenddy Carrero Castillo - Coordinadora Volumen 12
Alicia Marifernanda Zavala Calahorrano - Asistente editorial

Revista de Divulgación Científica
INVESTIGACIÓN Y DESARROLLO I+D
Volúmen 12, Número 1
P-ISSN: 1390-5546
E-ISSN: 2361-2557
revista.dide@uta.edu.ec
Desarrollo de un aplicativo móvil para el control de contagiados de Covid-19 Mobile app development for the control of people infected by Covid-19
Authors: Núñez Miranda Carlos , Moreta Romero Jessica , Rivera Rodríguez Giovanni , Tisalema Lascano Jonathan 
Published: July 2022

El presente artículo hace referencia al desarrollo de un aplicativo móvil dedicado a la prevención, alerta y cuidado de contagios en tiempo de pandemia por el COVID-19. La generalización por el trabajo y la educación en línea desde el hogar ha llevado a que empresas, tanto reconocidas a nivel mundial como desconocidas, se vean inmersas en la creación de aplicaciones para mantenerse conectados y vinculados para seguir en productividad, además que el mercado actual se basa en la descarga de aplicaciones tanto gratuitas como pagadas para Android e IOS dedicadas a la propagación de información del COVID-19. El aplicativo se enfoca en el conocimiento y la difusión de la información según la sintomatología que se presenten en las personas, se centra especialmente en la información suministrada a diferentes grupos de trabajo, con la finalidad de determinar la cantidad de individuos contagiados y sospechosos existentes, para posteriormente a ello realizar las respectivas notificaciones con el propósito de que se tomen acciones tanto como de prevención o aplicación de medidas de seguridad (cercos epidemiológicos), para evitar contagios