bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variability in detection of SARS-CoV-2-specific antibody responses following mild infection: a prospective multicentre cross-sectional study, London, United Kingdom, 17 April to 17 July 2020
Authors: Pallett Scott JC , Jones Rachael , Abdulaal Ahmed , Pallett Mitchell A , Rayment Michael , Patel Aatish , Denny Sarah J , Mughal Nabeela , Khan Maryam , Rosadas de Oliveira Carolina , Pantelidis Panagiotis , Randell Paul , Toumazou Christofer , O’Shea Matthew K , Tedder Richard , McClure Myra O , Davies Gary W , Moore Luke SP 
Published: January 2022

Introduction
Immunoassays targeting different SARS-CoV-2-specific antibodies are employed for seroprevalence studies. The degree of variability between immunoassays targeting anti-nucleocapsid (anti-NP; the majority) vs the potentially neutralising anti-spike antibodies (including anti-receptor-binding domain; anti-RBD), particularly in mild or asymptomatic disease, remains unclear.

Aims
We aimed to explore variability in anti-NP and anti-RBD antibody detectability following mild symptomatic or asymptomatic SARS-CoV-2 infection and analyse antibody response for correlation with symptomatology.

Methods
A multicentre prospective cross-sectional study was undertaken (April–July 2020). Paired serum samples were tested for anti-NP and anti-RBD IgG antibodies and reactivity expressed as binding ratios (BR). Multivariate linear regression was performed analysing age, sex, time since onset, symptomatology, anti-NP and anti-RBD antibody BR.

Results
We included 906 adults. Antibody results (793/906; 87.5%; 95% confidence interval: 85.2–89.6) and BR strongly correlated (ρ = 0.75). PCR-confirmed cases were more frequently identified by anti-RBD (129/130) than anti-NP (123/130). Anti-RBD testing identified 83 of 325 (25.5%) cases otherwise reported as negative for anti-NP. Anti-NP presence (+1.75/unit increase; p < 0.001), fever (≥ 38°C; +1.81; p < 0.001) or anosmia (+1.91; p < 0.001) were significantly associated with increased anti-RBD BR. Age (p = 0.85), sex (p = 0.28) and cough (p = 0.35) were not. When time since symptom onset was considered, we did not observe a significant change in anti-RBD BR (p = 0.95) but did note decreasing anti-NP BR (p < 0.001).

Conclusion
SARS-CoV-2 anti-RBD IgG showed significant correlation with anti-NP IgG for absolute seroconversion and BR. Higher BR were seen in symptomatic individuals, particularly those with fever. Inter-assay variability (12.5%) was evident and raises considerations for optimising seroprevalence testing strategies/studies.
The Role of Metacognitive Skills in Developing The 21st Century Skills
Authors: Damayanti Ade Mardiana , Syamsiyah Nur , Astuti Endang , Dania Uci , Kusumaningtyas Pintaka 
Published: January 2022

Metacognition is one of the most important dimensions of education in building knowledge, skills and character of students. The metacognitive skills are indispensable in developing the 21st century skills that must be mastered by students. This paper provides a review of literature that emphasizes on the 21st century skills that can be developed through the metacognition in learning. The finding reported the 21st century skills that can be developed in learning using the metacognitive skills included the ability in problem solving, critical thinking, reflective thinking and accessing information. As such, it can be concluded that the metacognitive skills of students can be one of the key factors in students’ successful in mastering the 21st century skills.
ANALISIS KEMAMPUAN MULTIREPRESENTASI MAHASISWA PENDIDIKAN FISIKA SEMESTER II TENTANG KONSEP SINAR MONOKROMATIS
Authors: Damasari Arita Fajar , Sudarti Sudarti 
Published: January 2022

Multi-representation is an integral part of the representation of science, especially physics. This study analyzes and evaluates the ability of physics education students regarding monochromatic rays. The research method used is the descriptive method with 40 respondents second semester of the physics education study program. The analysis was generated based on a questionnaire consisting of 8 verbal and picture questions that were answered correctly. The study resulted in a higher percentage of verbal multi-presentation abilities than picture multi-presentation. The value of verbal multi-representation presentation is 94.06% and picture multi-representation is 53.55 and the difference between the two is 40.51%. Further research is needed on appropriate learning methods to improve students' multi-representation abilities of images on monochromatic light material.
giovane poesia nella Svizzera italiana
Authors: Valentini Jordi 
Published: January 2022

The article provides a broad overview of the poetry produced in Italian-speaking Switzerland over the past twenty years. The first part presents three channels of poetry dissemination (journals, editorial projects, and literary festivals) both within and outside the Swiss-Italian territory. The second part reflects on some critical readings of Swiss-Italian poetry and addresses the reasons why some forms of poetic writing have appeared later or to a lesser degree within the Swiss territory than they have in Italy, despite the two countries’ proximity. From this analysis, it is argued that the lack of strong counter styles in Swiss-Italian poetry has hindered the development of more mature and diverse forms of poetic expression. In the conclusion, it is argued that the non-use of digital resources for poetry production and dissemination in Italian-speaking Switzerland, as well as an often short-sighted cultural policy, are other important points to address in order to promote dialogue within and beyond the Swiss-Italian border.

L’articolo fornisce una panoramica ampia della poesia prodotta nella Svizzera italiana negli ultimi vent’anni. La prima parte indaga tre principali canali di diffusione (riviste, case editrici, festival letterari) dentro e fuori il territorio della Svizzera italiana. La seconda parte riflette su alcune letture critiche della poesia nella Svizzera italiana e cerca di stabilire le ragioni per cui alcuni tipi di scrittura poetica siano giunti tardi o poco sul territorio svizzero rispetto all’Italia, nonostante la vicinanza tra i due paesi. Da questa analisi, si argomenta che la mancanza di controtendenze forti nella poesia nella Svizzera italiana abbia impedito lo svilupparsi di forme di espressione poetica più mature e diverse. In conclusione, si ritiene che il mancato uso di strumenti digitali per la produzione e la disseminazione della poesia nella Svizzera italiana, oltre che una politica culturale spesso poco lungimirante, siano temi importanti da affrontare per promuovere dialogo dentro e oltre il confine della Svizzera italiana.

English title
Young Poetry in Italian-speaking Switzerland. Publishing Strategies and Critical Readings
High-impact chronic pain transition in surgical recipients with cervical spondylotic myelopathy
Authors: Cook Chad E. , George Steven Z. , Asher Anthony L. , Bisson Erica F. , Buchholz Avery L. , Bydon Mohamad , Chan Andrew K. , Haid Regis W. , Mummaneni Praveen V. , Park Paul , Shaffrey Christopher I. , Than Khoi D. , Tumialan Luis M. , Wang Michael Y. , Gottfried Oren N. 
Published: January 2022

OBJECTIVE
High-impact chronic pain (HICP) is a recently proposed metric that indicates the presence of a severe and troubling pain-related condition. Surgery for cervical spondylotic myelopathy (CSM) is designed to halt disease transition independent of chronic pain status. To date, the prevalence of HICP in individuals with CSM and their HICP transition from presurgery is unexplored. The authors sought to define HICP prevalence, transition, and outcomes in patients with CSM who underwent surgery and identify predictors of these HICP transition groups.

METHODS
CSM surgical recipients were categorized as HICP at presurgery and 3 months if they exhibited pain that lasted 6–12 months or longer with at least one major activity restriction. HICP transition groups were categorized and evaluated for outcomes. Multivariate multinomial modeling was used to predict HICP transition categorization.

RESULTS
A majority (56.1%) of individuals exhibited HICP preoperatively; this value declined to 15.9% at 3 months (71.6% reduction). The presence of HICP was also reflective of other self-reported outcomes at 3 and 12 months, as most demonstrated notable improvement. Higher severity in all categories of self-reported outcomes was related to a continued HICP condition at 3 months. Both social and biological factors predicted HICP translation, with social factors being predominant in transitioning to HICP (from none preoperatively).

CONCLUSIONS
Many individuals who received CSM surgery changed HICP status at 3 months. In a surgical population where decisions are based on disease progression, most of the changed status went from HICP preoperatively to none at 3 months. Both social and biological risk factors predicted HICP transition assignment.
Thermal destruction of polymeric fibers in the theory of temporary dependence of strength
Authors: Kartashov E. M. 
Published: January 2022

Objectives. This study mathematically describes the mutual influence of micro- and macrostages of the process of destruction of polymer materials and determines its main parameters and limiting characteristics. In addition, a relationship is established between molecular constants characterizing the structure of a material and those characterizing its macroscopic characteristics of strength. Finally, theoretical representations of the thermokinetics of the process of thermal destruction of polymer fibers from the standpoint of the kinetic thermofluctuation concept are developed, which makes it possible to predict the thermal durability of a sample under thermal loading.Methods. The structural–kinetic thermofluctuation theory was used to describe the initial stages of the fracture process and to derive a generalized formula for the rate of crack growth. The mathematical theory of cracks is used to describe the thermally stressed state of a material in the vicinity of an internal circular crack under mechanical and thermal loadings of the sample.Results. A theoretical formula for the full isotherm of durability in the range of mechanical stresses from safe to critical, as well as a theoretical relationship for the time dependence of the strength of polymer fibers under purely thermal loading in the full range of heat loads from safe to critical and at the stage of nonthermal crack growth, is given. The main parameters and limiting characteristics of durability under thermal loading are also indicated.Conclusions. A generalized structural–kinetic theory of the fracture of polymer fibers under purely thermal action on cracked specimens is presented. The developed theory combines three independent approaches: structural–kinetic (thermofluctuation theory), mechanical, and thermodynamic. The obtained theoretical relations are of practical interest for the development of methods for localization, intensification, and control of the crack growth kinetics.
Hubungan Tingkat Spiritualitas Wanita Menopause dengan Sindrom Menopause pada Daerah Pedesaan
Authors: Sari Intan Indah , Sudarmiati Sari 
Published: January 2022

Introduction: Menopausal women experience a number of symptoms called menopausal syndrome. Previous study) states that menopausal syndrome in women in Europe reaches 70-80%, Americans 60%, Malaysia 57%, China 18%, Japan and in Indonesia 10%. The prevalence and severity of menopausal syndrome in Asia show lower rates than women in Western. Another study states, high spiritual well-being can provide adaptive coping and contribute to reducing menopausal symptoms. Studies on the relationship between the spiritual level of menopausal women and menopausal syndrome in rural areas are still limited. The study aims to determine the relationship of spirituality levels with menopausal syndrome in rural area. Method: This study is correlation research with cross sectional approach. Number of samples is 207 women. The sampling technique used stratified random sampling. The research was conducted in Tangkisan Village, Tawangsari District, Sukoharjo Regency. Instruments used in this study is Spiritual Well-Being Scale (SWBS) to measure spirituality levels and Menopausal Rating Scale (MRS) to determain the level of menopausal syndrome. The quesionnare distributed online by whatsapp.using google form. Data analysis using using Spearman rank test. Result: The analysis showed that there was a significant relationship between the level of spirituality with menopausal syndrome in women with a correlation value of -0,300 and p value ≤ 0,05.Conclusion: A high level of spirituality reduced menopausal syndrome. Menopausal women are expected to prepare and improve their spirituality to be more ready to undergo menopause.
Financial and legal bases for the formation of territorial communities capable budgets
Authors: Korobtsova D. V. , Mishchenko L. V. 
Published: January 2022

The formation of UTC budgets requires not only the improvement of the structure of tax revenues, as well as the analysis of revenues, but currently the use of intergovernmental transfers as important additional revenues of UTC budgets in modern research is the subject of discussion.
The budgetary and legal relations which are formed at the level of formation of budgets of the united territorial communities are investigated, and the financial and legal bases of formation of capable budgets are defined. Examples of scientific research on various aspects of local finance as factors influencing the formation, distribution and use of national budget funds, as a legal institution and as a basis for comparative characteristics of domestic and foreign practice of local budgeting, etc. are considered. The main problems that arise in the way of optimizing the revenue policy of local budgets of the united territorial communities in the conditions of financial decentralization are described.
The set of tasks on which the provision of financial capacity of the territorial community depends is analyzed. The main steps that the state must take to implement the budget decentralization reform effectively are identified. It is stated that during the formation of a promising united territorial community it is important to calculate its financial capacity in advance, which will allow to assess the benefits and risks of such association, determine the need for additional funds and streamlining expenditures, and to envisage its further functioning for the purpose of its socio-economic development. The concept of "UTC budget" and the essence of the concept of "capable budget" are specified. Based on the historical experience of budget relations in Ukraine and foreign experience, the need to form viable budgets at the expense of alternative revenues , namely by providing UTC rights to establish indirect taxes, regulate benefits and tax rates, income from business activities, and the use of intergovernmental transfers in the required amounts and for specific purposes is proved.
Philosophical, general scientific and special methods of scientific cognition are used, and also formation of the balanced and substantiated income and expense parts of budgets in the volume sufficient for performance of the set tasks is found out. The legal bases for formation of the revenue part of the budget at the expense of both tax and non-tax revenues and financing of certain types of expenditures are analyzed. Proposals for improving the financial legislation regarding the terminology and essence of budget activities are substantiated.
Preparación de docentes en la atención educativa a escolares doblemente excepcionales
Authors: Martínez-Rangel Adriana Yosahandi , Castellanos-Simons Doris , López-Aymes Gabriela 
Published: January 2022

El objetivo del estudio que se reporta fue analizar el nivel de sensibilización y preparación de los maestros para detectar y brindar atención educativa a alumnos con “doble excepcionalidad” - Altas Capacidades (AC) y Trastorno por Déficit de Atención e Hiperactividad (TDAH), con el fin de determinar sus necesidades de orientación y capacitación en una escuela primaria del sector privado en Morelos.
Se desarrolló un estudio descriptivo, cualitativo, en el que participaron los docentes que impartían clases a escolares de una primaria de Xochitepec con diagnóstico previo de TDAH emitido por especialistas, y evaluación de AC mediante diferentes instrumentos. Con cada docente se desarrollaron entrevistas semiestructuradas para recolectar datos que permitieran identificar sus necesidades de preparación en el área. Derivado del diagnóstico de los participantes, se diseñó e implementó un programa de intervención. El proceso formativo se caracterizó por posibilitar una reflexión compartida respecto a la necesidad de brindar una atención educativa acorde a las características y necesidades de los alumnos, a partir de un enfoque basado en el reconocimiento de sus fortalezas para propiciar un ambiente desarrollador para todos los alumnos. Los docentes asumieron una postura autocrítica y tomaron conciencia de la trascendencia de su rol en el desarrollo del potencial de los alumnos.
A saúde mental de crianças e adolescentes refugiados e suas consequências na gênese da síndrome da resignação
Authors: Matias Ingrid de Sousa , Lima Wliana Pontes de , Ferreira Matheus Leite , Silva Víctor José Alves , Sampaio Débora Belém , Ribeiro Pedro José Targino 
Published: January 2022

Esta pesquisa teve como objetivo averiguar a repercussão dos fluxos migratórios na saúde mental de crianças e adolescentes refugiados, como também verificar qual o impacto dessas alterações mentais na gênese da síndrome da resignação. Para isso, fez-se uso de uma revisão integrativa de literatura nas bases de dados eletrônicas: LILACS, SciELO, Frontiers e na revista FIDES-UFRN. Utilizaram-se os seguintes descritores: “Refugiados”, “Saúde Mental”, “Criança”, “Síndrome” e “Coma”. O operador booleano “AND” foi utilizado. Incluíram-se artigos disponíveis na íntegra; publicados entre 2016 e 2021; em português, inglês ou espanhol; cujos títulos e resumos estivessem em consonância com o propósito deste estudo. Excluíram-se teses, dissertações e resumos de anais. Posteriormente, foram realizadas a coleta, análise crítica e síntese dos dados. A síndrome da resignação configura-se como uma patologia ainda obscura e pouco detalhada, no tocante a sua etiologia e a fisiopatologia envolvidas. Infere-se também, que os estudos voltados a análise da saúde mental de crianças refugiadas ainda são escassos, porém os dados apontam para existência direta de sofrimento psíquico nessa faixa etária, o que relaciona-se ao surgimento da síndrome supracitada. Conclui-se, a partir dos dados levantados, que ocorre sofrimento psíquico nas crianças que vivenciam uma migração involuntária. As repercussões desse processo na saúde mental de crianças refugiadas, ilustradas pela síndrome da resignação, revelam a magnitude do sofrimento mental desencadeado por migrações extenuantes e demoradas, marcadas por violência e intolerância, que configuram um problema de saúde pública.
Interleukin-1β More Than Mechanical Loading Induces a Degenerative Phenotype in Human Annulus Fibrosus Cells, Partially Impaired by Anti-Proteolytic Activity of Mesenchymal Stem Cell Secretome
Authors: Gonçalves Raquel M. , Saggese Taryn , Yong Zhiyao , Ferreira Joana R. , Ignatius Anita , Wilke Hans-Joachim , Neidlinger-Wilke Cornelia , Teixeira Graciosa Q. 
Published: January 2022

Mesenchymal stem/stromal cell (MSC)–based therapies for low back pain and intervertebral disc (IVD) degeneration have been emerging, despite the poor knowledge of their full mechanism of action. As failure of the annulus fibrosus (AF) is often associated with IVD herniation and inflammation, the objective of the present study was to investigate the impact of the MSC secretome on human AF cells exposed to mechanical loading and a pro-inflammatory environment. Human AF cells isolated from IVD biopsies from patients with adolescent idiopathic scoliosis (AIS) or disc degeneration (DD) were exposed to physiological cyclic tensile strain (CTS) for 72 h in a custom-made device, with or without interleukin (IL)-1β medium supplementation. AF cells stimulated with CTS + IL-1β were then treated with secretome from IL-1β–preconditioned MSCs for 48 h. AF cell metabolic activity, gene expression, protein secretion, matrix metalloproteinase (MMP) activity, and tissue inhibitor of MMPs (TIMP) concentration were evaluated. Expanded AF cells from AIS and DD patients revealed similar metabolic activity and gene expression profiles. CTS stimulation upregulated collagen type I (COL1A1) expression, while IL-1β significantly stimulated IL-6, IL-8, MMP-1, and MMP-3 gene expression and prostaglandin E2 production by AF cells but downregulated COL1A1. The combination of CTS + IL-1β had a similar outcome as IL-1β alone, accompanied by a significant upregulation of elastin. The MSC secretome did not show any immunomodulatory effect on CTS + IL-1β–stimulated AF cells but significantly decreased MMP-1, MMP-2, MMP-3, and MMP-9, while increasing the production of TIMP-1. The obtained results demonstrate a stronger impact of the inflammatory milieu on human AF cells than upper physiologic mechanical stress. In addition, a new MSC mechanism of action in degenerated IVD consisting of the modulation of AF MMP activity was also evidenced, contributing to the advancement of knowledge in AF tissue metabolism.
Piloting an Intervention to Improve Outcomes in Young Adults Living With Type 1 Diabetes: The Experience of the D1 Now Support Worker
Authors: Lowry Michelle , Morrissey Eimear C. , Dinneen Sean F. 
Published: January 2022

IntroductionD1 Now is a novel intervention which aims to support self-management and clinic engagement and improve outcomes in young adults (18-25 years) living with type 1 diabetes in Ireland. It has been developed using a systematic, theoretical, user-centred approach. The specific role of the Support Worker, one of three components of the D1 Now intervention, was developed to provide continuity and build relationships between young adults and their diabetes team.MethodsA Support Worker - an Occupational Therapist, who had a background in youth mental health - was hired as part of the D1 Now pilot randomised controlled trial and was based in one intervention site to join the existing diabetes team.DiscussionThe Support Worker aimed to provide an accessible and consistent point of contact for young adults, facilitated conversations about distress, and encouraged graded goal setting and collaborative problem solving. The role afforded her with a unique window into the lived experiences of young adults with type 1 diabetes where she observed the ongoing negotiation of life and living alongside diabetes care and management. The prevalence of diabetes distress was high in the study cohort with particular challenges associated with ‘all or nothing’ thinking patterns as well as disordered eating behaviours. The Support Worker also played an advocacy role in supporting the diabetes team’s awareness of young adults’ needs and explored current barriers to care. Preliminary findings from the D1 Now pilot have identified that the role of the Support Worker was viewed positively from the perspective of young adults with type 1 diabetes.