bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fundamental care: An evolutionary concept analysis
Authors: Ottonello Giulia , Napolitano Francesca , Musio Maria Emma , Catania Gianluca , Zanini Milko , Aleo Giuseppe , Timmins Fiona , Sasso Loredana , Bagnasco Annamaria 
Published: October 2022

AbstractAimTo report an analysis of the concept of fundamental care in the literature.DesignAn evolutionary concept analysis.Data sourcesPubMed and CINAHL Complete databases were consulted using the key terms: fundamental care, fundamentals of care, essential care, basic nursing care and basic care revised. Articles published from 2008 to 2022, in English and Italian, in scholarly/peer‐reviewed nursing journals were included.MethodsRodgers's Evolutionary Method of concept analysis was used. Our thematic analysis yielded common themes related to the concept, antecedents, attributes and consequences of fundamental care.ResultsA total of 50 articles were analysed. Thirty‐eight attributes were identified, such as integration of care, patient and family centred care and trusting relationship; eight antecedents including nursing care, nursing practice and care context; and 17 consequences including the safety, quality and consistency of care.ConclusionThis review of literature reveals that there is no consistent definition of the concept of ‘fundamental care’. Findings from this exploration of the literature emphasized the importance of communication, the contextual environment, leadership influence and nurse–patient relationship in providing effective and high‐quality fundamental care. Our definition of this concept may help nurse leaders in practice, research, education, management and policy to promote and enhance the application of fundamental care.Impact
What problem did the study address?
While numerous studies examine fundamental nursing care, various terms are used with no consensus on definitions emerging. Given the relevance of this topic, reaching a clear and agreed definition of fundamental care is essential.
What were the main findings?
Fundamental care encompasses the importance of communication, the contextual environment, leadership influence and nurse‐patient relationship in providing effective and high‐quality care.
Where and on whom will the research have an impact?
This definition of fundamental care will assist nurse leaders and researchers to promote and enhance the examination and application of fundamental care in clinical practice to ensure better care outcomes across all healthcare settings.
Global mental health experiences of single mothers: A mixed methods research synthesis
Authors: Vo Timothea , Canty Lucinda 
Published: October 2022

AbstractAimThe aim of this research is to synthesize findings from primary studies (quantitative and qualitative) that investigated the global mental health experiences of single mothers to provide a deeper understanding to better care and respond to the support needs of single mothers.DesignHayvaert et al.'s mixed methods research synthesis approach.Data SourcesThe search process in the following databases, CINAHL, PsycINFO, and Scopus resulted in eight high‐quality studies (5 qualitative and 3 quantitative) published between June 2016 and July 2021.Review MethodsDescriptive statistics and instrument scores were provided in summary form. Themes were analysed using Krippendorff's content analysis. A joint display was provided to reveal a complementary relationship between two different data sets.ResultsA total of 348 single mothers participated. Amongst the pooled sample, women identified as: Japanese (n = 174), Israeli (n = 147), Black African (n = 18), African American (n = 9), Native American (n = 5), Burundian‐Australian (n = 8), UK British (n = 12), Asian (n = 3), South Korean (n = 7), Indian (n = 2), Malaysian (n = 44), Hispanic/Latina (n = 1) and Eastern European (n = 3). Four themes were identified: (1) Learning to let go of the past, (2) It takes a whole village: Importance of social support, (3) Seeking a self‐reliant life: Challenges with balancing career & childcare and (4) Finding strength within: Personal growth. Only one intervention utilizing creative group counselling was found to significantly decrease depression (p = .008), anxiety (p = .005), and stress (p = .012) whilst increasing self‐compassion (p = .013).ConclusionIt is important for clinicians who care for single mothers, particularly if they recently immigrated, are multiparous, and an ethnic minority to encourage engagement in peer‐initiated counselling and obtain mental health care as necessary.ImpactThis study identified and addressed the mental health issues that single mothers face worldwide. This is also the first mixed methods research synthesis to report single mothers' ethnicity in nursing and midwifery literature. Thus, findings from this mixed methods research synthesis can help nurses worldwide build culturally‐concordant programs in their respective community organizations and partners (e.g. community health centres, mother‐child enrichment clubs), inform health policies, and promote safer spaces for many single mothers, particularly for those who will immigrate to the Global North (i.e. UK, US, Canada) and become an ethnic minority.
The effects of social and organizational connectedness on employee well‐being and remote working experiences during the COVID‐19 pandemic
Authors: Brown Adam , Leite Ana C. 
Published: October 2022

AbstractMaintaining social connectedness is crucial for health and well‐being—especially during uncertain times such as the COVID‐19 pandemic. The present study examined (1) the effects of general and organizational indicators of connectedness on employee well‐being and (involuntary) remote work experiences during lockdown and (2) whether organizational connectedness attenuated the ill effects of isolation on employee well‐being. Full‐ and part‐time workers (N = 188) recruited during the UK's second national COVID‐19 lockdown completed a questionnaire measuring time spent interacting and alone during lockdown, social connectedness, organizational identification, perceived organizational support, organizational communication, ill‐being, organizational well‐being (i.e., well‐being at work), and remote working experiences. Hierarchical regression analyses revealed that those with greater social connectedness and organizational support reported less ill‐being. In contrast, those spending more time alone and, unexpectedly, those strongly identifying with their organization, reported more ill‐being. Additionally, those who felt greater organizational support had more positive remote working experiences, whereas stronger organizational identification negatively related to the latter. Only organizational support was significantly associated with (more positive) well‐being at work. Furthermore, moderation analyses showed that time spent alone during the pandemic was associated with poorer organizational well‐being but only among those with lower levels of organizational identification, and those whose organizational communication strategies were poorer. These findings demonstrate that indicators of organizational connectedness played a distinct role in explaining ill‐being, workplace well‐being, and remote working experiences, above and beyond the effects of general connectedness, during lockdown.
Environmental filtering and habitat (mis)matching of riverine invertebrate metacommunities
Authors: Murray‐Stoker David , Murray‐Stoker Kelly M. , Kong Fan Peng , Amanat Fathima 
Published: October 2022

AbstractAimMetacommunities are assembled through a combination of local and regional processes, with the relative importance of the drivers of assembly depending on ecological context. Global change can alter community assembly at both local and regional levels, potentially shifting communities into disequilibrium with their local environmental conditions. We evaluated the spatial variation in environmental filtering and habitat matching of 1078 riverine macroinvertebrate communities distributed across nine ecoregions.LocationConterminous United States.TaxonFreshwater macroinvertebrates.MethodsPatterns in environmental filtering, habitat matching and functional trait diversity were compared among ecoregions. Boosted regression trees were used to identify (1) functional trait predictors of environmental filtering and habitat matching and (2) environmental, landscape and network variables that predict functional trait abundances.ResultsEnvironmental filtering but not habitat matching varied strongly by ecoregion. Functional trait diversity varied by ecoregion, but not as strongly as the signatures of environmental filtering. Functional trait predictors of environmental filtering and habitat matching were not consistent, with trait predictors instead varying by individual traits, trait categories and ecoregions. Notwithstanding inconsistent trait predictors, environmental filtering was primarily influenced by habitat preference traits, whereas habitat matching was primarily influenced by both habitat preference and dispersal traits. Predictors of functional traits also varied by trait category and ecoregion, with habitat preference and dispersal traits primarily influenced by network variables.Main conclusionsOur study demonstrates the contingent patterns and drivers of environmental filtering and habitat matching on a macroecological scale. We provide the foundation on which trait–environment relationships can be further quantified and causal explanations established in the context of community disequilibrium and applied to conservation and management of freshwater systems.
Origin and timing of de novo variants implicated in type 2 von Willebrand disease
Authors: Chen Ming , Shen Ming‐Ching , Chang Shun‐Ping , Ma Gwo‐Chin , Huang Ying‐Chih , Lin Ching‐Yeh 
Published: October 2022

AbstractVery few studies have shown the real origin and timing of de novo variants (DNV) implicated in von Willebrand disease (VWD). We investigated four families with type 2 VWD. First, we conducted linkage analysis using single nucleotide variant genotyping to recognize the possible provenance of DNV. Second, we performed amplification refractory mutation system‐quantitative polymerase chain reaction to confirm the real origin of variant (~0% mutant cells) or presence of a genetic mosaic variant (0%–50% mutant cells) in three embryonic germ layer‐derived tissues and sperm cells. Then, three possible timings of DNV were categorized based on the relative likelihood of occurrence according to the number of cell divisions during embryogenesis. Two each with type 2B VWD (proband 1 p.Arg1308Cys, proband 4 p.Arg1306Trp) and type 2A VWD (proband 2 p.Leu1276Arg, proband 3 p.Ser1506Leu) were identified. Variant origins were identified for families 1, 2 and 3 and confirmed to originate from the mother, father and father, respectively. However, the father of family 4 was confirmed to have isolated germline mosaicism with 2.2% mutant sperm cells. Further investigation confirmed the paternal grandfather to be the origin of variant. Thus, we proposed that DNV originating from the two fathers most likely occurred at the single sperm cell, the one originating from the mother occurred at the zygote during the first few cellular divisions; alternatively, in family 4, the DNV most likely occurred at the early postzygotic development in the father. Our findings are essential for understanding genetic pathogenesis and providing accurate genetic counselling.
Inhibition of Pseudomonas aeruginosaLPS‐Induced airway inflammation by RIPK3 in human airway
Authors: Yun Minsu , Park Sun‐Hee , Kang Dong Hee , Kim Ji Wook , Kim Ju Deok , Ryu Siejeong , Lee Jeongyeob , Jeong Hye Min , Hwang Hye Ran , Song Kyoung Seob 
Published: October 2022

AbstractAlthough the physiological function of receptor‐interacting protein kinase (RIPK) 3 has emerged as a critical mediator of programmed necrosis/necroptosis, the intracellular role it plays as an attenuator in human lungs and human bronchial epithelia remains unclear. Here, we show that the expression of RIPK3 dramatically decreased in the inflamed tissues of human lungs, and moved from the nucleus to the cytoplasm. The overexpression of RIPK3 dramatically increased F‐actin formation and decreased the expression of genes for pro‐inflammatory cytokines (IL‐6 and IL‐1β), but not siRNA‐RIPK3. Interestingly, whereas RIPK3 was bound to histone 1b without LPS stimulation, the interaction between them was disrupted after 15 min of LPS treatment. Histone methylation could not maintain the binding of RIPK3 and activated movement towards the cytoplasm. In the cytoplasm, overexpressed RIPK3 continuously attenuated pro‐inflammatory cytokine gene expression by inhibiting NF‐κB activation, preventing the progression of inflammation during Pseudomonas aeruginosa infection. Our data indicated that RIPK3 is critical for the regulation of the LPS‐induced inflammatory microenvironment. Therefore, we suggest that RIPK3 is a potential therapeutic candidate for bacterial infection‐induced pulmonary inflammation.
Hepatoprotective effect of nanoniosome loaded Myristica fragrans phenolic compounds in mice‐induced hepatotoxicity
Authors: Poorbagher Mahsa Rastegar Moghaddam , Karimi Ehsan , Oskoueian Ehsan 
Published: October 2022

AbstractIn this study, nanoniosome‐loaded Myristica fragrans' (MF) phenolic compounds (NLMP) were synthesized and characterized for their physical properties, and hepatoprotective effects on mice with liver toxicity induced by L‐asparaginase (LA) injection. According to the results, NLMP has a spherical shape with a 263 nm diameter, a zeta potential of −26.55 mV and a polydispersity index (PDI) of 0.192. The weight and feed intake of mice induced with hepatotoxicity were significantly (p ≤ 0.05) increased after they were treated with NLMP (2.5 mg/kg body weight of mice). In addition, the blood levels of triglyceride (TG), cholesterol (Chol), liver enzymes (aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP)) and total bilirubin were significantly (p ≤ 0.05) decreased. A significant increase (p ≤ 0.05) in the blood levels of the antioxidant defence system (glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT)) were also reported after NLMP treatment. NLMP was also led to a significant decrease (p ≤ 0.05) in inflammatory‐related gene expression of inducible nitric oxide synthase (iNOS) and Interferon‐gamma (IFN‐γ) in the liver, as well as a meaningful (p ≤ 0.05) increase in the expression of SOD as an antioxidant status biomarker. Consequently, the NLMP is recommended as a potential dietary supplement to alleviate the symptoms of LA‐induced hepatotoxicity.
First record of mating behaviour and induced parturition of the Brazilian endemic Lutz's stingray Hypanus berthalutzae
Authors: Bettcher Vanessa B. , Bucair Nayara , Granville Marta , Góes Amanda , Mendes Liana de Figueiredo , Di Dario Fabio , de Moura Rodrigo Leão , Garla Ricardo , Rangel Bianca S. 
Published: October 2022

AbstractThe recently described Lutz's stingray Hypanus berthalutzae is endemic to the Brazilian Province, including oceanic islands. Although it is expected to have life‐history traits similar to the southern stingray H. americanus, little is known about its reproductive biology. Here we present the first observations of courtship behaviour (n = 4), copulation (n = 3) and an induced parturition of H. berthalutzae at the Fernando de Noronha Archipelago, an insular Marine Protected Area from the Equatorial Atlantic Ocean. The mating event records included (1) ‘chasing/close following’, (2) ‘biting/precopulatory biting’, (3) ‘insertion/copulation’ and (4) ‘separation’. These results are especially relevant considering that records of reproductive behaviour in the wild are rare for elasmobranchs in general. Mating events occurred in different months, suggesting that the reproductive cycle of H. berthalutzae in this insular system is asynchronous, as observed for other stingray species in regions with favourable environmental conditions and abundant food throughout the year. The opportunistic documentation of the induced parturition allowed for direct nonlethal observation of the two pups at or near full term in late May. Although preliminary, these observations should be considered in future management plans as they provide relevant data about the life‐history traits and mating behaviour of this endemic and threatened species.
Sentiment or habits: Why not both?
Authors: Tham Eric 
Published: October 2022

AbstractHabits and sentiment are important psychological behaviors in asset pricing. In this article I nest consumer sentiment as a risk factor into the Campbell–Cochrane (CC) habit model and examine its impact on asset prices. The model provides an economic mechanism for the pricing of sentiment risk through its impact on habit sensitivity and equilibrium habit levels but finds its market price of risk much lower than fundamentals. The additional sentiment factor does not improve the CC model, with both models returning a matched moments error of from 1980Q1 to 2021Q4. The sentiment factor, however, subsumes risk aversion with a lower resulting risk coefficient than the CC model without sentiment. Furthermore, the model shows that during the COVID period, the risk premium was driven more by consumption growth than sentiment.
Experiential learning, practices, and space for change: The institutional preconfiguration of community participation in flood risk reduction
Authors: Cook Brian R. , Cornes Isabel , Satizábal Paula , de Lourdes Melo Zurita Maria 
Published: October 2022

AbstractResponding to societal challenges requires an understanding of how institutional change happens or does not happen. In the context of flood risk reduction, a central impediment of transformational change is a struggle over how public participation is understood and practiced. Risk institutions are often portrayed as resistant to change, which overlooks the individuals within institutions who struggle to implement innovative power‐sharing approaches/arrangements. Using two rounds of qualitative interviews spread over 5 years, this research identifies factions within the risk sector—those who view participation as awareness raising and those who are struggling to make participation part of a wider commitment to power‐sharing: a group that, for the purpose of this analysis, we call “mavericks.” Through focus on how mavericks struggle for change, this analysis uncovers tensions that arise as individuals attempt to alter prevailing knowledge‐practices. The findings highlight the importance of experiential learning, active listening, and the alteration of space. By applying a relational conceptualisation, we explore how mavericks advocate for relationship building, which alters spaces of public participation and, in that way, lays the foundation for transformational social innovations. The conclusions offer flood risk researchers perspective on the institutional struggles that preconfigure how frontrunner projects are or are not able to facilitate the community participation needed to successfully implement societal transformations.
Heat shock factor HSF1 regulates BDNF gene promoters upon acute stress in the hippocampus, together with pCREB
Authors: Franks Hunter , Wang Ruishan , Li Mingqi , Wang Bin , Wildmann Ashton , Ortyl Tyler , O'Brien Shannon , Young Deborah , Liao Francesca‐Fang , Sakata Kazuko 
Published: October 2022

AbstractHeat shock factor 1 (HSF1) is a master stress‐responsive transcriptional factor, protecting cells from death. However, its gene regulation in vivo in the brain in response to neuronal stimuli remains elusive. Here, we investigated its direct regulation of the brain‐derived neurotrophic factor (BDNF) gene (Bdnf) in response to acute neuronal stress stimuli in the brain. The results of immunohistochemistry and chromatin immunoprecipitation quantitative PCR (ChIP‐qPCR) showed that administration of kainic acid (a glutamate receptor agonist inducing excitotoxity) to young adult mice induced HSF1 nuclear translocation and its binding to multiple Bdnf promoters in the hippocampus. Footshock, a physical stressor used for learning, also induced HSF1 binding to selected Bdnf promoters I and IV. This is, to our knowledge, the first demonstration of HSF1 gene regulation in response to neuronal stimuli in the hippocampus in vivo. HSF1 binding sites (HSEs) in Bdnf promoters I and IV were also detected when immunoprecipitated by an antibody of phosphorylated (p)CREB (cAMP‐responsive element‐binding protein), suggesting their possible interplay in acute stress‐induced Bdnf transcription. Interestingly, their promoter binding patterns differed by KA and footshock, suggesting that HSF1 and pCREB orchestrate to render fine‐tuned promoter control depending on the types of stress. Further, HSF1 overexpression increased Bdnf promoter activity in a luciferase assay, while virus infection of constitutively active‐form HSF1 increased levels of BDNF mRNA and protein in vitro in primary cultured neurons. These results indicated that HSF1 activation of Bdnf promoter was sufficient to induce BDNF expression. Taken together, these results suggest that HSF1 promoter‐specific control of Bdnf gene regulation plays an important role in neuronal protection and plasticity in the hippocampus in response to acute stress, possibly interplaying with pCREB.image
Evaluation of the adipokine levels of pregnant women with preeclampsia
Authors: Gök Soner , Gök Berfin Can , Enli Yaşar 
Published: October 2022

AbstractAimThe aim of this study was to compare maternal blood and umbilical‐cord leptin, spexin and visfatin levels during delivery in severe preeclampsia (PE) with controls, and to evaluate whether any clinical or demographic variables had independent associations with them.MethodsThis is a case‐controlled observational study consisting of 45 pregnant women with severe PE and a control group consisting of gestational age‐matched 45 healthy pregnant women. We examined the leptin, spexin, and visfatin levels in serum samples taken from maternal blood and umbilical cords during cesarean section in both groups. Leptin, spexin, and visfatin levels were measured by enzyme‐linked immunosorbent assay.ResultsThe maternal leptin and visfatin levels were significantly higher and the maternal spexin levels were significantly lower in the PE group than in the control group (p < 0.001). Similar to the maternal adipokine levels, the umbilical‐cord leptin and visfatin levels were significantly higher and the spexin levels were significantly lower in the PE group (p < 0.001). We found a significant positive correlation between maternal body mass index and maternal blood and umbilical‐cord serum leptin and visfatin levels in both groups (p < 0.001).ConclusionThe leptin, spexin and visfatin levels were significantly altered in the nondiabetic preeclamptic women in our study. We believe that the main reason for these changes may be the hypoxic placenta to protect the fetus and maintain its nutrition.