bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attraction of Pissodes castaneus (Coleoptera, Curculionidae) to Pinus taeda: Laboratory and Field Evaluation
Authors: Frensch Gustavo , Zaleski Scheila R. M. , Schorr Renan R. , Dantas Liliane G. , Krasniak Marina , Lazzari Sonia M. N. , Maia Beatriz H. L. N. S. , Marques Francisco A. 
Published: June 2022

Abstract
Coniferous trees of the genus Pinus (Pinaceae) are under continuous threats by numerous herbivorous insect species and pathogens attacking nearly all parts and tissues of the plants. To defend themselves, pine trees produce large amounts of oleoresin that is accumulated in a highly developed network of specialized resin ducts, which are distributed in the wood, bark, and needles. Such defense reactions in pines can be induced by the attack of herbivores. The banded pine weevil, Pissodes castaneus (De Geer, 1775) (Coleoptera, Curculionidae), is an important pest of Pinus in Brazil, where it has been an invasive species since 2001. The female lays its eggs under the tree bark of trees and the larvae feed in the phloem of the trunk and branches, interrupting the sap circulation and eventually causing its death. In the present study, we conducted detailed GC–MS analyses of volatiles emitted by twigs of Pinus taeda L. We analyzed how the attack by P. castaneus males and females affects the volatile pattern emitted by the twigs. When comparing volatiles produced by healthy plants and by female- and male-attacked P. taeda, qualitative and quantitative differences were detected, as the decreased production of limonene, germacrene D and (E)-caryophyllene and the increase of α-pinene. Laboratory bioassays showed that plants attacked by male and female P. castaneus were more attractive to the insects. Understanding about what compounds may attract or repel the insects may help in the development of more effective traps, as well as preventing stress to avoid infestation.
Assessment of the nasal microbiota in dogs with fungal rhinitis before and after cure and in dogs with chronic idiopathic rhinitis.
Authors: Vangrinsven Emilie , Fastrès Aline , Taminiau Bernard , Billen Frédéric , Daube Georges , Clercx Cécile 
Published: June 2022

Abstract
Background
Pathogenesis of canine fungal rhinitis is still not fully understood. Treatment remains challenging, after cure intranasal remodeling may be associated with clinical disease mimicking chronic idiopathic rhinitis and recurrence can occur. Alterations of the nasal microbiota have been demonstrated in dogs with chronic idiopathic rhinitis and nasal neoplasia, although whether they play a role in the pathogenesis or are a consequence of the disease is still unknown. The objectives of the present study were (1) to describe nasal microbiota alterations associated with fungal rhinitis in dogs, compared with chronic idiopathic rhinitis and controls, (2) to characterize the nasal microbiota modifications associated with successful treatment of fungal rhinitis. Forty dogs diagnosed with fungal rhinitis, 14 dogs with chronic idiopathic rhinitis and 29 healthy control dogs were included. Nine of the fungal rhinitis dogs were resampled after successful treatment with enilconazole infusion.
Results
Only disease status influenced the nasal microbiota variance. The relative abundance of the genus Moraxella was decreased in the fungal rhinitis (5.4 ± 18%) and chronic idiopathic rhinitis (4.6 ± 8.7%) groups compared to controls (51.8 ± 39.7%). Fungal rhinitis and chronic idiopathic rhinitis groups also showed an increased richness and α-diversity at species level compared with controls. Increase in unique families were associated with fungal rhinitis (Staphyloccaceae, Porphyromonadaceae, Enterobacteriaceae and Neisseriaceae) and chronic idiopathic rhinitis (Pasteurellaceae and Lactobacillaceae). In dogs with fungal rhinitis at cure, only 1 dog recovered a high relative abundance of Moraxellaceae.
Conclusions
Results confirm major alterations of the nasal microbiota in dogs affected with fungal rhinitis and chronic idiopathic rhinitis, consisting mainly in a decrease of Moraxella. Besides, a specific dysbiotic profile further differentiated fungal rhinitis from chronic idiopathic rhinitis. In dogs with fungal rhinitis, whether the NM returns to its pre-infection state or progresses toward chronic idiopathic rhinitis or fungal rhinitis recurrence warrants further investigation.
Analysis of Antibiotic Resistance and Molecular Characteristics in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates
Authors: Zhang Ranran , Zhu Jingxuan , Chen Ye , Yang Xuejing 
Published: June 2022

Abstract
The global epidemic of carbapenem-resistant Klebsiella pneumonia (CRKP) has brought a significant public health challenge. We collected 62 clinical isolated CRKP strains to investigate the antibiotic resistance, molecular characteristics and the clinical characteristics of infected patients. The carbapenemase gene, virulence-associated gene, capsular serotype gene and fenestra protein gene were detected by PCR. All the CRKP isolates were resistant to meropenem, piperacillin-tazobactam, and ceftazidime (100%, 62/62, respectively), followed by imipenem and cefepime (96.8%, 61/62, respectively). The resistance rate of colistin was lowest (11.9%, 8/62). The resistance rate of CRKP in ICU to various antibiotics were significantly higher than general ward patients. 50 strains carried carbapenemase gene blaKPC, and 3 strains carry both blaKPC and blaNDM. The virulence genes uge, wabG, ycf, entB, ureA and fimH were detected above 90% in 62 CRKP strains. 2 strains in 62 CRKP strains had Ompk35, Ompk36 and Hcp gene deletion. BlaKPC, rmpA and rmpA2 genes have the highest positive rate in blood samples, and blaNDM have the highest positive rate in stool samples. The multivariate analysis showed that patient with pulmonary disease affected the prognosis of the CRKP infection. Our results demonstrated that antibiotic resistance and widespread dissemination of CRKP has become one of the most difficult challenge in clinical infection therapy. The relevant genes of strains and clinical characteristics of patients are related to the progression and prognosis of CRKP infection.
A GNN-based Proactive Caching Strategy in NDN Networks
Authors: Hou Jiacheng , Lu Haoye , Nayak Amiya 
Published: June 2022

Abstract
As people spend more time watching and sharing videos online, it is critical to provide users with a satisfactory quality of experience (QoE). Leveraging the in-network caching and named-based routing features in Named Data Networks (NDNs), our paper aims to improve user experience through caching. We propose a graph neural network-gain maximization (GNN-GM) cache placement algorithm. First, we use a GNN model to predict users’ ratings of unviewed videos. Second , we consider the total predicted rating of a video as the gain of the cached video. Third, we propose a cache placement algorithm to maximize the caching gain and actively cache videos. Cache replacement is implemented based on the cache gain ranking of videos, with higher cache gain videos replacing lower cache gain videos. We compare GNN-GM with two state-of-the-art caching strategies, namely the NMF-based caching strategy and GNN-CPP. GNN-GM is also compared with two traditional caching strategies, LCE and LRU, LCE and FIFO. We evaluate the five caching strategies using real-world datasets in a tree network topology, a real-world network topology GEANT, and various random topologies. The experimental results show that our caching policy significantly improves cache hit ratio, latency and server load. Notably, GNN-GM achieves a 25% higher cache hit rate, 5% lower latency and 7% lower server load than GNN-CPP in GEANT.
Networking Data and Intelligent Management in the Post-COVID19 Era: A Report on APNOMS 2021
Authors: Chen Jen-Jee , Yamamoto Ryo , Kim Kyungbaek , Huang Jiun-Long , Kinoshita Kazuhiko , Seok Woojin , Yen Li-Hsing 
Published: June 2022

Abstract
This article presents a report on APNOMS 2021, which was held on September 8–10, 2021 in Tainan, Taiwan. The theme of APNOMS 2021 was “Networking Data and Intelligent Management in the Post-COVID19 Era.”
Spontaneous electrochemical uranium extraction from wastewater with net electrical energy production
Authors: Ye Yin , Jin Jian , Han Wei , Miao Shiyu , Feng Yanyue , Qin Zemin , Tang Xin , Li Cui , Chen Yanlong , Chen Fan , Wang Yuheng 
Published: June 2022

Abstract
Extracting uranium from uranium-mine wastewater is highly important from both the environmental protection and the resource preservation perspectives. However, conventional adsorption methods and zero-valent-iron induced reductive precipitation methods have intrinsic limitations. Here we demonstrate a spontaneous electrochemical (SPEC) method that spatially decouples the uranium-adsorption-reduction reactions and the iron oxidation reaction, enabling stable and efficient uranium extraction with net electrical energy output. U(VI) species are firstly adsorbed on a carbonaceous electrode, and subsequently reduced by electrons derived from iron oxidation. In simulated wastewater, the SPEC method achieves a 12 times higher uranium extraction efficiency without saturation of the carbonaceous electrode, in comparison with the adsorption method. In real wastewater, the uranium extraction efficiency reaches 352 mg∙g-1 during 60 h operation with simultaneous net electrical energy production (0.65 Wh∙m-2), and the operation cost is only 3.46~5.99 USD∙kgU-1. This work potentially opens a new avenue for cost-effective uranium recovery from mine wastewater.
Investigating Xiaoqinglong Decoction in the Treatment of Allergic Rhinitis by Negatively Regulating HDAC in Mouse Model
Authors: Liu Hao-Lan , Chen Hui-Fang , Liu Qin-Dong , Xu Wei-zhen , Yan Ya-jie , Zhang Jia-Jun , He Xue-Cheng , Ruan Yan , Zhou Min 
Published: June 2022

Abstract
As one of the most common allergic diseases, allergic rhinitis (AR) has attracted wide attention all over the world. Appropriate treatment of allergic rhinitis should be explored thoroughly. In recent years, more attention has been paid to the advantages of traditional Chinese medicine in the treatment of AR. Xiaoqinglong decoction (XQLD) as a classical Chinese medicine prescription has been commonly used in treating AR. Even though its therapeutic effect on AR has been clinically confirmed, more therapeutic mechanisms remain to be further investigated. Our research aimed to investigate the therapeutic mechanism of XQLD for AR management. Liquid chromatography–mass spectrometry (LC–MS) was adopted to test the stability of XQLD’s effective components. The research was evaluated in an ovalbumin sensitized AR mouse model. The results confirmed the stability and safety of the effective components of XQLD. XQLD significantly downregulated the expression of HDACs (HDAC1, HDAC3 and HDAC4) and Th2 inflammatory factors (IL4, IL5 and IL13) in AR mice. XQLD and the HDAC inhibitor JNJ-26481585 promoted the expression of epithelial tight junction proteins (Claudin-1 and ZO-1) and decreased the expression of mucins (Muc5ac and Muc5b) in the nasal mucosa of AR mice. In conclusion, our findings confirm that XQLD may be responsible for the recovery of nasal epithelial dysfunction and inhibiting Th2 inflammation in AR by downregulating HDAC expression and HDAC is a crucial and promising target of XQLD for AR treatment. This study provides an important experimental proof for elucidating the therapeutic mechanism of XQLD.
Florida's Coral Reef is Eroding
Authors: Morris John T. , Enochs Ian C. , Besemer Nicole , Viehman T. Shay , Groves Sarah H. , Blondeau Jeremiah , Ames Cory , Towle Erica K. , Grove Laura Jay W. , Manzello Derek P. 
Published: June 2022

Abstract
Coral reef habitat is created when calcium carbonate production by calcifiers exceeds removal by physical and biological erosion. Carbonate budget surveys provide a means of quantifying the framework-altering actions of diverse assemblages of marine species to determine net carbonate production, a single metric that encapsulates reef habitat persistence. In this study, carbonate budgets were calculated for 723 sites across the Florida Reef Tract using benthic cover and parrotfish demographic data from NOAA’s National Coral Reef Monitoring Program, as well as high-resolution LiDAR topobathymetry. Results highlight the erosional state of the majority of the study sites, with a trend towards more vulnerable habitat in the northern Florida Reef Tract, especially in the Southeast Florida region, which is in close proximity to urban centers. Detailed comparison of reef types reveals that mid-channel reefs in the Florida Keys have the highest net carbonate production and indicates that these reefs may be hold-outs for reef development throughout the region. This study reports that Florida reefs, specifically their physical structure, are in a net erosional state. As these reefs lose structure, the ecosystem services they provide will be diminished, signifying the importance of increased protections and management efforts to offset these trends.
A shared fate: Adapting and personalising medical care from the perspective of a refugee reception country
Authors: Śniadecki Marcin , Zuzanna  
Published: June 2022

Abstract
The article outlines socio-medical challenges faced by a country hosting refugees. Since the full-scale Russian invasion, more than 3.6 million Ukrainians have fled to Poland. Among these, a 9-year-old post-transplant patient, Tetiana. The story of the girl and her family reveals the refugees’, the authors’, and other doctors’ varied attitudes towards the war. Considering differences between the Polish and Ukrainian health care systems, and the need for well-coordinated and effective assistance, a professional, and realistically financed system needs to be established. The presence of Ukrainian doctors is potentially advantageous because of the shared language with Ukrainian refugees. Notwithstanding the medical community’s demonstrable solidarity, the months of effort and the awareness that many people may not be helped may result in burnout. Supporting others starts with us, so that neither poor management, nor cultural differences or simple fatigue, undermine the community cohesion that Poles and Ukrainians can build together.
Longitudinal association of handgrip strength with all-cause and cardiovascular mortality from a causal framework
Authors: López-Bueno Rubén , Andersen Lars Louis , Calatayud Joaquín , Casaña José , Smith Lee , Jacob Louis , Koyanagi Ai , Cruz Borja del Pozo 
Published: June 2022

Abstract
Background
To date, there is no study addressing the time-varying confounding bias in the association of handgrip strength (HGS) with all-cause or cardiovascular mortality. Therefore, we conducted marginal structural models (MSM) to provide causal estimations on the associations of HGS with all-cause and cardiovascular mortality in a representative sample of adults aged 50 years or older.
Methods
Data from 29 countries including 121 116 participants (276 994 observations; mean age 63.7 years; 56.3% women) free from prior heart attack or stroke were retrieved from consecutive waves of the Survey of Health, Ageing and Retirement in Europe (SHARE). During a median of 7.7 years follow-up (interquartile range 3.8–11.8) and 1,009,862 person-years, 6407 participants (5.3%) died due to all causes, and 2263 (1.9%) died due to cardiovascular diseases. Using repeated measures of handheld dynamometry, we determined absolute and relative to body mass index HGS of each participant. We applied adjusted MSM to estimate hazard ratios (HRs) associated with changes over time in HGS addressing the time-varying confounding bias. An increase of 5 kg in HGS was associated with a reduced risk of all-cause [HR 0.86, 95% confidence interval (CI), 0.86–0.90], overall cardiovascular (HR 0.86, 95% CI 0.82–0.86), heart attack (HR 0.90, 95% CI 0.86–0.95), and stroke (HR 0.86, 95% CI 0.82–0.90) mortality. The associations of relative HGS were of stronger magnitude in all cases.
Conclusions
Our findings provide critical evidence on the importance of increasing general muscle strength in middle-aged to older adults to reduce mortality risk, particularly concerning cardiovascular causes.
Machine Learning to Predict Long and Short Term Fracture Risk in Postmenopausal Women
Authors: Radhachandran Ashwath , Maharjan Jenish , Barnes Gina , Shokouhi Sepideh , Hoffman Jana , Mao Qingqing 
Published: June 2022

Abstract
Purpose
Fractures in older adults are a significant cause of morbidity and mortality, particularly for post-menopausal women with osteoporosis. Prevention is key for managing fractures in this population and may include identifying individuals at high fracture risk and providing therapeutic treatment to mitigate risk. This study aimed to develop a machine learning fracture risk prediction tool to overcome the limitations of existing methods by incorporating additional risk factors and providing short-term risk predictions.
Methods
We developed a machine learning model to predict risk of major osteoporotic fractures and femur (hip) fractures in a retrospective cohort of post-menopausal women. Models were trained to generate predictions at 3, 5, and 10 year prediction windows. The model used only ICD codes, basic demographics, vital sign measurements, lab results and medication usage from a proprietary national longitudinal electronic health record repository to make predictions.
Results
The algorithms obtained area under the receiver operating characteristic values of 0.83, 0.81, and 0.79 for prediction of major osteoporotic fractures at 3, 5, and 10 year windows, respectively. The algorithms also obtained AUROC values of 0.79, 0.75, and 0.75 for prediction of femur fractures at 3, 5, and 10 year windows, respectively. For all models, when sensitivity was fixed at 0.80, average specificity was 0.615.
Conclusion
Machine learning clinical decision support may inform clinical efforts at early detection of high-risk individuals, mitigating their risk and for establishing clinical research cohorts with well-defined patient populations.
Fine-scale mapping of physicochemical and microbial landscapes clarifies the spatial structure of the coral skeleton microbiome
Authors: Ricci Francesco , Tandon Kshitij , Moßhammer Maria , Cho Ellie H-J , Blackall Linda L. , Kühl Michael , Verbruggen Heroen 
Published: June 2022

Abstract
The coral skeleton harbours a diverse community of bacteria and microeukaryotes exposed to gradients of light, O2 and pH, but how such physicochemical gradients affect the coral skeleton microbiome remains unclear. We employed chemical imaging of O2 and pH, hyperspectral reflectance imaging and spatially explicit taxonomic and functional microbiome characterisation to explore links between the skeleton microenvironment and microbiome in the reef-building corals Porites lutea and Paragoniastrea australensis. The physicochemical environment was more stable in the deep skeleton and the diversity and evenness of the bacterial community increased with depth, suggesting that the microbiome was stratified along the physicochemical gradients. The bulk of the coral skeleton was a low O2 habitat, whereas pH showed a great variation with depth between pH 6 and 9. Physicochemical gradients of O2 and pH of the coral skeleton correlated with the β-diversity of the bacterial communities. Skeletal layers that showed O2 peaks had a higher relative abundance of endolithic algae, reflecting a strong link between the abiotic environment and the microbiome composition. Altogether, these results link the physicochemical, microbial and functional landscapes of the coral skeleton and provide new insights into the involvement of skeletal microbes in the holobiont metabolism.
OSeMOSYS Global: An open-source, open data global electricity system model generator
Authors: Barnes Trevor , Shivakumar Abhishek , Brinkerink Maarten , Niet Taco 
Published: June 2022

Abstract
This paper describes OSeMOSYS Global, an open-source, open-data model generator for creating global electricity system models for an active global modelling community. This version of the model generator is freely available and can be used to create interconnected electricity system models for both the entire globe and for any geographically diverse subset of the globe. Compared to other existing global models, OSeMOSYS Global allows for full user flexibility in determining the time slice structure and geographic scope of the model and datasets, and is built using the widely used fully open-source OSeMOSYS energy system model. This paper describes the data sources, structure, and use of OSeMOSYS Global, and provides illustrative workflow results.
High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection
Authors: Ichinohe Takeshi , Nagai Minami , Moriyama Miyu , Ishii Chiharu , Mori Hirotake , Watanabe Hikaru , Nitta Yuuka , Arimitsu Noriko , Nishimoto Moe , Nakahara Taku , Yamada Takuji , Ishikawa Dai , Ishikawa Takamasa , Hirayama Akiyoshi , Kimura Ikuo , Nagahara Akihito , Naito Toshio , Fukuda Shinji 
Published: June 2022

Abstract
While a common symptom of influenza and coronavirus disease 2019 (COVID-19) is fever, its physiological role on host resistance to viral infection remains less clear. Here, we demonstrate that exposure of mice to the high ambient temperature of 36 °C increase host resistance to viral pathogens including influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). High heat-exposed mice increase basal body temperature over 38 °C to enable more bile acids production in a gut microbiota-dependent manner. The gut microbiota-derived deoxycholic acid (DCA) and its plasma membrane-bound receptor Takeda G-protein-coupled receptor 5 (TGR5) signaling increase host resistance to influenza virus infection by suppressing virus replication and neutrophil-dependent tissue damage. Furthermore, the DCA and its nuclear farnesoid X receptor (FXR) agonist protect Syrian hamster from lethal SARS-CoV-2 infection. Moreover, we demonstrate that certain bile acids are reduced in the plasma of COVID-19 patients who developed moderate I/II disease compared with minor illness group. These findings uncover an unexpected mechanism by which virus-induced high fever increases host resistance to influenza virus and SARS-CoV-2 in a gut microbiota-dependent manner.
AMPK deficiency in smooth muscles causes persistent pulmonary hypertension after birth and premature death
Authors: Moral-Sanz Javier , Lewis Sophronia , MacMillan Sandy , Meloni Marco , Foretz Marc , del-Pozo Jorge , McClaffterty Heather , Viollet Benoit , Evans A. 
Published: June 2022

Abstract
We address a paradox, that AMPK may facilitate hypoxic pulmonary vasoconstriction and its deficiency precipitate pulmonary hypertension. Here we show that AMPKα1/α2 deficiency in smooth muscles promotes persistent pulmonary hypertension of the newborn. Accordingly, dual AMPK-α1/α2 deletion in smooth muscles causes premature death of mice after birth, associated with increased muscularization and remodeling throughout the pulmonary arterial tree, reduced alveolar numbers and alveolar membrane thickening, but with no edema. Spectral Doppler ultrasound indicates pulmonary hypertension and attenuated hypoxic pulmonary vasoconstriction. Agedependent right ventricular pressure elevation, dilation and reduced cardiac output was also evident. KV1.5 potassium currents of pulmonary arterial myocytes are markedly smaller under normoxia, which is known to facilitate pulmonary hypertension. Mitochondrial fragmentation and reactive oxygen species accumulation is also evident. Importantly, there is no evidence of systemic vasculopathy or hypertension in these mice. Moreover, hypoxic pulmonary vasoconstriction is attenuated by AMPK-α1 or AMPKα2 deletion without triggering pulmonary hypertension.