bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of long term outcomes in patients managed with VV-ECMO in the first and second waves of the COVID-19 pandemic in the UK
Authors: Garfield Benjamin , Bianchi Paolo , Arachchillage Deepa J , Caetano Francisca , Desai Sujal , Doyle James , Caballero Clara Hernandez , Doyle Anne-Marie , Mehta Sachin , Law Alexander , Jaggar Sian , Kokosi Maria , Molyneaux Philip L , Passariello Maurizio , Naja Meena , Ridge Carole , Alçada Joana , Patel Brijesh , Singh Suveer , Ledot Stephane 
Published: April 2022

Abstract
BackgroundEarly studies of veno-venous extracorporeal membrane oxygenation (VV-ECMO) in COVID-19 have revealed similar outcomes to historical cohorts. Changes in the disease and treatments has led to differences in the patients supported on VV-ECMO in the 1st and 2nd waves. We aimed to compare these two groups in both the acute and follow-up phase.MethodsIn this retrospective study, we identified the differences between patients supported on ECMO for COVID-19 between wave 1 (17/03/2020-31/08/2020) and wave 2 (01/09/2020-25/05/2021). We examined mortality at censoring date (30/11/2021) and decannulation, patient characteristics, complications and lung function and quality of life (QOL – by EQ5D3L) at first follow-up.FindingsOne-hundred and twenty-three patients were included in our analysis. Survival at censoring date [Chi-sqaured 6.35, p=0.012] and decannulation [90.4% vs 70.0%, p<0.001], was significantly lower in the 2nd wave, whilst duration of ECMO run was longer [12.0(18.0-30.0) days vs. 29.5(15.5-58.3)] days (p=0.005)). Wave 2 patients had longer application of non-invasive ventilation (NIV) prior to ECMO and a higher incidence of barotrauma. Patient age and NIV use were independently associated with increased mortality [OR 1.07(1.01-1.14), p=0.025 and 3.37(1.12–12.60), p=0.043 respectively]. QOL and lung function, apart from KCOc was similar at follow up across the waves.ConclusionMost patients with COVID-19 supported on ECMO in both waves survived in the short and longer term. At follow-up patients had similar lung function and QOL across the 2 waves. This suggests that ECMO has an ongoing role in the management of a carefully selected group of patients with COVID-19.Trial RegistrationResearch Ethics Committee (20/EM/0204)
An 18.9-minute Blue Large-Amplitude Pulsator Crossing the "Hertzsprung Gap'' of Hot Subdwarfs
Authors: Lin Jie , Wu Chengyuan , Wang Xiaofeng , Németh Péter , Xiong Herang , Wu Tao , Filippenko Alexei , Cai Yongzhi , Brink Thomas , Yan Shengyu , Zeng Xiangyun , Luo Yangpin , Xiang Danfeng , Zhang Jujia , Zheng W , Yang Yi , Mo Jun , Xi Gaobo , Zhang Jicheng , Iskandar Abdusamatjan , Esamdin Ali , Jiang Xiaojun , Sai Hanna , Wei Zixuan , Chen Liyang , Guo Fangzhou , Chen Zhihao , Li Wenxiong , Lin Weili , Lin Han , Zhang Xinhan 
Published: April 2022

Abstract
Blue large-amplitude pulsators (BLAPs) represent a new and rare class of hot pulsating stars with unusually large amplitudes and short periods. Up to now, only 21 confirmed BLAPs have been identified from more than one billion monitored stars, including a group with pulsation period longer than 20 min (classical BLAPs; [1]) and the other group with pulsation period below 10 min (high-gravity BLAPs; [2]). The evolutionary path that could give rise to such kinds of stellar configurations is unclear. Here we report on a comprehensive study of the peculiar BLAP discovered by the Tsinghua University – Ma Huateng Telescopes for Survey (TMTS) [3], TMTS J035143.63+584504.2 (TMTSBLAP-1); it is the first confirmed BLAP located within the “period gap” between high-gravity and classical BLAPs. This new BLAP has an 18.9 min pulsation period, and is similar to the classical BLAPs with an extended helium-enriched envelope. In particular, the long-term monitoring data of TMTS-BLAP-1 reveal that this pulsating star has an unusually large rate of period change, ˙P /P = 2.3 × 10−6 yr−1. Such a significant and positive value challenges the scenarios of both the helium-core pre-white-dwarf and the core-helium burning [1, 2, 4–6]), but is consistent with that derived from shell-helium burning. The particular pulsation period and unusual rate of period change indicate that TMTS-BLAP-1 is at a short-lived (∼ 106 yr) phase of shell-helium ignition before the stable shell-helium burning; in other words, TMTSBLAP-1 is going through a “Hertzsprung gap” of hot subdwarfs. This demonstrates that hot subdwarf stars have a similar evolutionary fate as main-sequence stars; some subdwarfs can leave their “main-sequence” stage and appear as diverse pulsating variables in distinct regions of the Hertzsprung-Russell diagram, thereby opening a new window for explorations of rare pulsating stars that evolved from stripped-envelope stars.
Optimization design of process parameters for cold and hot composite roll forming of the AHSS square tube using response surface methodology
Authors: Wang Yu , Mehari Zelalem Abathun , Wu Junyuan , Han Jingtao 
Published: April 2022

Abstract
Advanced high-strength steel (AHSS) is a highly competitive material for the automobile industry to resolve the challenge of weight reduction and passenger safety. With the increase in strength, defects such as microcrack, local thickness reduction, and large corner radius in the corner section of cold roll-formed steel products become more and more serious. Cold and hot composite roll forming (CHCRF) is a newly developed manufacturing technology that combines the advantages of cold and hot forming to overcome the challenge of forming AHSS. In this paper, the mathematical models that represent the effect of line velocity, heating power, and deformation amount on the yield strength, outer corner radius, and microcrack length of the corner section of cold and hot composite roll-formed AHSS square tube are investigated by the response surface methodology (RSM) with Box-Behnken design (BBD). From the analysis of variance (ANOVA), it is found that all the three process parameters play a significant role in the outer corner radius and microcrack length, while the line velocity and heating power influence the yield strength significantly. Furthermore, an optimization process is proposed, with the outer corner radius and microcrack length as objective functions and the yield strength as a constrained condition, to manufacture the AHSS square tube with a small outer corner radius and no microcrack defect. Experimental verification has been conducted using the optimal process parameters, and the average magnitude of error is about 5%, which implies that the optimization design is accurate and reliable.
Fabrication of nanohydroxyapatite-chitosan coatings by pulse electro deposition method
Authors: Shahverdi Najme , Montazeri Arash 
Published: April 2022

Abstract
In this study, Mg-2wt% Zn scaffolds were fabricated by powder metallurgy method and the effects of the porosity content on the microstructure and the mechanical properties of the scaffolds were studied. The nano hydroxyapatite-chitosan (nHA-CS) coatings were developed using pulse electro deposition (PED) method to improve corrosion resistance and biocompatibility of scaffolds in the solution body fluids (SBF). The effect of PED parameters (voltage and time) and nHA/CS ratio were studied to achieve optimal nanocomposite coating. The results showed that optimal coating was obtained at voltage 40 V, 10 minutes of coating time and nHA/CS ratio =10. The pulse-peak current density (CD), the pulse duty cycles (DC), pH and temperature for the fabrication of the coatings were conducted at 10 mA cm-2, 0.2 ,7 and 37oC, respectively. In optimal coating, the nHA atomic ratio was obtained Ca/P=1.57, similar to the value of bone hydroxyapatite. The in vitro biocompatibility of the optimal coating was evaluated by cell adhesion, cytotoxicity and alkaline phosphatase (ALP) assays using MG63 cells. The results indicate that the optimal nanocomposite coating was highly biocompatible, making this material more suitable for applications in bone tissue engineering and to repair bone defects caused by sports injuries.
Prognostic Biomarkers and Therapeutic Targets Identiﬁcation Among CXC Chemokines in the Colon Adenocarcinoma Microenvironment
Authors: wang heng , guo changqing , luo jun , li quan , Fu BuQing , jiang wei 
Published: April 2022

Abstract
BackgroundCOAD is among the most prevalent malignancy, with a very high incidence rate. Crosstalk between cancer and interstitial cells significantly affects cancer development, modulated partly by chemokines production. When present in the tumor microenvironment, CXC chemokines have been shown to regulate tumor cell activity and influence immune cell transport, resulting in anti-tumor immune mechanisms and influencing the outcomes of the patient; nonetheless, the CXC chemokines expression levels in COAD, as well as their prognostic significance, have not yet been established. MethodsThis study used UALCAN, GeneMANIA, STRING, TRRUST, cBioPortal, TIMER, and GEPIA, ResultsThe expression of CXC1/2/3/5/6/11/12/13/14/16/17 in COAD patients was shown to be significantly correlated with the pathological stage. A considerably improved prognosis was observed in patients with low transcriptional levels of CXCL9/10/11. Differentially expressed CXC chemokines exert roles that are predominantly correlated with the chemokine signaling pathway and interactions of cytokine–cytokine receptors. Our findings indicated that the transcriptional factors, including SP1, RELA, and NFKB1 are essential for the production of CXC chemokines. Furthermore, we discovered a substantial association between the CXC chemokines production and infiltration of 6 kinds of immune cells (CD8+ T cells, dendritic cells, B cells, CD4+ T cells, neutrophils, and macrophages,). ConclusionsThese findings might be useful in identifying prognostic indicators and immunotherapeutic targets for colon cancer.
Genome-wide identification and functional analysis of Dof transcription factor family in Camelina sativa
Authors: Li Runzhi , Luo Tao , Song Yanan , Gao Huiling , Wang Meng , Cui Hongli , Ji Chunli , Yuan Lixia , Wang Jiping 
Published: April 2022

Abstract
Background: Dof transcription factors (TFs) containing C2-C2 zinc finger domains are plant-specific regulatory proteins, playing crucial roles in a variety of biological processes. However, little is known about Dof in Camelina sativa, an important oil crop worldwide, with high stress tolerance. In this study, a genome-wide characterization of Dof proteins is performed to examine their basic structural characteristics, phylogenetics, expression patterns, and functions to identify the regulatory mechanism underlying lipid/oil accumulation and the candidate Dofs mediating stress resistance regulation in C. sativa.Results: Total of 103 CsDof genes were identified from the C. sativa genome, and they were classified into four groups (A, B, C and D). These genes were spread unevenly across 20 chromosomes. All of the CsDof proteins contained the highly-conserved typic CX2C-X21-CX2C structure. Segmental replication was detected to be the main force for expansion of CsDof gene family, and purifying selection happened during CsDof’s evolution. More than half of CsDof genes were expressed in multiple tissues, and a number of them showed tissue-specific expression patterns, suggesting that CsDof genes functioned differentially in different tissues of C. sativa. Remarkably, a set of CsDof members may mediate regulation of oil/lipid biosynthesis in C. sativa. Six CsDof genes exhibited significant expression changes in seedlings under salt stress treatment.Conclusions: This article describes a detailed analysis of the CsDof gene family and its expression profiles in various tissues and under salt stress. Segmental duplication is the key force responsible for the expansion of this gene family, and a strong purifying pressure plays a crucial role in CsDofs’ evolution. Several CsDof TFs may mediate lipid metabolism and stress responses in C. sativa. Collectively, our results provide a foundation for deep understanding the roles of CsDofs and genetic improvements of oil yield and stress resistance in this species and the related crops.
Intracerebroventricular delivery of glatiramer acetate: a proof-of-concept treatment for Alzheimer’s disease by promoting innate phagocytosis and antagonizing amyloid-β toxicity
Authors: Huang Xin , Chen Feng , Doughty Larissa , Li Qiao-Xin , Ou Wensi , Li Yihan , Drysdale Candace , Alrehaili Arwa , Birchall Ian E. , Wong Joelyn , Park Keunha , Lim Michael , Sun Mujun , Semple Bridgette D. , Shultz Sandy R. , Adlard Paul A. , Parker Michael W. , McKinley Michael , Masters Colin L. , Wiley James S. , Gu Ben J 
Published: April 2022

Abstract
Background: We and others have reported that glatiramer acetate promotes innate phagocytosis. Methods: In this study, we investigated the interaction between glatiramer acetate and amyloid-β (Aβ) by using circular dichroism and microscale thermophoresis. Glatiramer acetate was delivered intracerebroventricularly to 22-month-old APP/PS1 mice by using mini-osmotic pumps. Mice underwent behavioural testing for two consecutive weeks after three-weeks treatment. Five weeks after implantation, animals were sacrificed and brain samples were collected for electrophysiology, immunochemistry and histopathology studies. Intracerebroventricular delivery of glatiramer acetate to sheep was also examined. Results: Glatiramer acetate binds to amyloid-β within high affinity and antagonize its toxicity. Glatiramer acetate treatment significantly improved cognitive function, restored long-term potentiation, reduced soluble amyloid-β and amyloid-β plaques in aged APP/PS1 mice, and promoted energy metabolism in sheep. Conclusions: Our results suggest a novel treatment strategy that targets both innate phagocytosis and amyloid-β, which may prove useful for treatment of all stages of Alzheimer’s disease.
Using Participatory Action Research to pilot a model of service user and caregiver involvement in mental health system strengthening in Ethiopian primary healthcare: A case study
Authors: Abayneh Sisay , Lempp Heidi , Kohrt Brandon , Alem Atalay , Hanlon Charlotte 
Published: April 2022

Abstract
Background
Little is known about actual involvement or how to achieve service user and caregiver in mental health systems strengthening in low-and middle-income countries. This study describes the processes and explores involvement experiences of participants in a pilot study of a new model of service user involvement in mental health system strengthening in a rural district in southern Ethiopia.
Methods
We applied a case study design using participatory action research (PAR). The PAR process comprised of three stages, each with iterative activities of plan, act, observe and reflect. Two stakeholder groups, a Research Advisory Group (RAG) and Research Participant Group (RPG), were established and collaborated in the PAR process. Data collection involved process documentation of meetings and activities: attendances, workshop minutes, discussion outputs, reflective notes, participatory observation of sessions, and in-depth interviews with 12 RPG members. We analyzed the process data descriptively. Thematic analysis was used for qualitative data. Triangulation and synthesis of findings was carried out to develop the case study.
Results
The stakeholder groups identified their top research priorities, developed an intervention and action plan and made a public presentation of preliminary findings. Key mechanisms used for inclusive participation included capacity building and bringing together diverse stakeholders, anchoring the study in established strong community involvement structures, and making use of participatory strategies and activities during the PAR process. Four themes were developed about experiences of involvement in PAR: (i) expectations and motivation,(ii) experiences of the dynamics of the PAR process,(iii) perceived impacts of involvement in the PAR process, and (iv) implementation challenges and future directions.
Conclusion
This case study demonstrated the feasibility and acceptability of implementing a complex model of service-user involvement in mental health system strengthening in a resource constrained setting. More needs to be done to embed service-user involvement into routines of the primary healthcare system, alongside sustained support and strengthening multi-stakeholder collaboration at multiple levels.
Spatial distribution patterns of microbiome and nematodes in response to sediment ecological conditions
Authors: Vieira Soraia , Sroczyń Kasia , Neves Joana , Martins Marta , Costa Maria Helena , Adão Helena , Vicente Claudia 
Published: April 2022

Abstract
Benthic organisms are crucial in the regulation of the ecosystem functions. They are primary mediators of the energy transfer in marine benthic food webs. Trophic interactions between benthic nematodes and sediment bacteria across divergent environmental conditions are poorly understood. The main goal of this study was to comprehend the relation between the spatial distribution patterns and diversity of benthic microbial communities and nematode assemblages of the intertidal sediments in Sado estuary (SW, Portugal). Samples were taken from three sites with different biogeochemical sediment conditions. Microbial communities were described using metagenomic approach, while nematode assemblages were characterized using morphological identification. Bacterial communities and nematodes assemblages presented significant heterogeneity between sites (p<0.05), which were primary related with the environmental variables (e.g., organic matter deposits and gravel percentage). However, while microbiome distributional patterns were clearly in accordance with ecological conditions of three selected sites (adjusted R2Adj = 0.53), nematode assemblages were more responsive to specific sampling locations within each site, suggesting that their response is rather driven by the within site specific factors, acting at the smaller spatial scale. Our study also demonstrated that the presence of Cyanobacteria (higher relative abundance of Pleurocapsa PCC-7319) seemed to be correlated with high abundance of nematode deposit feeders Terschellingia and Sabatieria indicating possible interactions between these taxa. Our study represents a first insight into bacteria–nematodes associations underlying ecological conditions thereby providing an important baseline for the future understanding of the role that these two groups play in the benthic estuarine ecosystem.
Persistent trigeminal artery detected on computed tomography angiography
Authors: Deniz Muhammed Akif , Turmak Mehmet , Hattapoğlu Salih , Tekinhatun Muhammed 
Published: April 2022

Abstract
PurposeThis study aimed to investigate the prevalence of persistent trigeminal arteries (PTAs) using computed tomography (CT) angiography, emphasize its major characteristics, and compare the findings with those reported in the relevant literature.MethodsPatients who underwent cerebral CT angiography in our radiology clinic for any preliminary diagnosis between December 2013 and December 2020 were included in this retrospective study. The patients were reviewed in terms of their age, sex, and the presence of PTAs. The localization of the PTA, vascular connection, PTA type (according to Saltzman and Salas classification), and vascular pathology at the level of anastomoses were examined in the patients with PTAs.ResultsA total of 1150 patients, (632 [55%] males and 518 [45%] females) were included in this study. A total of seven (0.6%) patients had PTAs. PTAs were located on the right and left sides in 3 (43%) and 4 (57%) patients, respectively. A total of 3 (43%), 2 (28%), and 2 (28%) cases were classified as types I, II, and III PTA based on the Saltzman classification, respectively. Moreover, 4 (57%) and 3 (43%) cases were lateral and medial types based on the Salas classification, respectively.ConclusionIn conclusion, understanding the diagnosis and classification of PTAs is crucial for the diagnosis of possible vascular pathologies by neuroradiologists and physicians performing neurovascular interventional procedures or operations. If these vascular pathologies remain undetected, they may cause fatal bleeding or embolism during surgeries and endovascular procedures.
The Evaluation of Geomorphosites with using Geomorphological Heritage (a Case Study of the Southern part of the Novohradské Mountains, the Czech Republic)
Authors: Rypl Jiří , Kirchner Karel , Kraft Stanislav , Blažek Vojtěch 
Published: April 2022

Abstract
At present, the protection of a biotic nature is more preferred than the protection of an abiotic nature. However, processes of a biotic nature and an abiotic nature are together with human activities deciding factors influencing significantly the landscape in general and therefore it is necessary to identify and evaluate specific geological and geomorphological sites in order to protect abiotic nature.This atricle dealt with new information from the territory of the Southern part of the Novohradské Mountains, aimed on the issues of geomorphosites. Geoheritage values which were attributed to the individual localities in the target territory, can serve as a significant foundation and source of the information for the appropriate authorities for the management of these geomorphosites.
The wettability and phosphate adsorption characteristics of katoite in RM were studied by first-principle calculations
Authors: Zhou Xiaotian , Li Longjiang , Qiu Yueqin , Liu Wanshuang 
Published: April 2022

Abstract
Red mud (RM) alone as an adsorbent for phosphorus shows unsatisfactory adsorption performance. This paper studied the wettability of katoite (the main component of RM) and its adsorption of phosphate. We also analysed the adsorption law of phosphate-containing water clusters on the katoite surface from bond length changes of the unit cell, adsorption equilibrium conformation, radial distribution function, interaction energy, adsorption isotherm and adsorption heat. found that kattenite has good wettability and the adsorption of phosphate is the result of van der Waals force and hydrogen bond.
Measurement of an evaporation coefficient in tissue sections as a correction factor for 10B determination
Authors: Espector Natalia , Portu Agustina Mariana , Espain María Sol , Leyva Gabriela , Martin Gisela Saint 
Published: April 2022

Abstract
Boron Neutron Capture Therapy (BNCT) is a cancer treatment option that combines preferential uptake of a boron compound in tumor and irradiation with thermal neutrons. For treatment planning, boron concentration in different tissues must be considered. Neutron Autoradiography using Nuclear Track Detectors (NTD) can be applied to study both boron concentration and microdistribution in tissue samples. Histological sections are obtained from frozen tissue by cryosectioning. When they reach room temperature, they undergo an evaporation process, which leads to an increase of boron concentration in the sample. In order to take this effect into account, certain correction factors (Evaporation Coefficients, CEv) must be applied. With this aim, a protocol was established in order to register and analyze mass variation of tissue sections, measured with a semimicro scale. Values of ambient temperature, pressure and humidity were simultaneously recorded. Reproducible results of evaporation curves and CEv values were obtained for different tissue samples, which allowed the systematization of the procedure. This study contributes to a more precise determination of boron concentration in tissue samples through the Neutron Autoradiography technique, which is of great relevance to make dosimetric calculations in BNCT.