bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential DNA Methylation Patterns in Primary and Recurrent Glioblastoma : A Protumorigenic Role for the TEM8 Gene
Authors: Kundu Paramita , Jain Ruchi , Kanuri Nandaki Nag , Arivazhagan A. , Santosh Vani , Kondaiah Paturu 
Published: March 2022

Abstract
Introduction : Glioblastomas are infiltrative malignant brain tumors which mostly recur within a year’s time, following surgical resection and chemo-radiation therapy. Studies on glioblastoma cells following radio-chemotherapies, have been demonstrated to induce trans-differentiation, cellular plasticity, activation of DNA damage response and stemness. Methods : Utilizing the Illumina 450K BeadChip Arrays, we compared the DNA methylation profile of primary (first occurrence) tumors with recurrent (relapsed) disease, in order to delineate the contribution of epigenetic changes associated with therapy exposure, therapy resistance, and relapse of the disease. Results : Our data revealed 1224 hypermethylated- and 526 hypomethylated-probes in recurrent glioblastomas compared to primary disease. We found differential methylation of solute carrier and ion channel genes, interleukin receptor/ligand genes, tumor-suppressor genes and genes associated with metastasis. We functionally characterized one such hypomethylated-upregulated gene, namely ANTXR1/TEM8 (Anthrax Toxin Receptor 1/Tumor Endothelial Marker 8), whose RNA was validated to be significantly upregulated in recurrent glioblastoma compared to primary tumors and confirmed by immunohistochemistry. Using overexpression and knockdown approaches, we show TEM8 induced proliferation, invasion, migration, and chemo-radioresistance in glioma cells. Mechanistically, we demonstrate β-catenin stabilization and activation of the β-catenin transcriptional program due to TEM8 over-expression. Inhibitor experiments revealed involvement of Src/PI3K/AKT/GSK3β/β-catenin pathway on TEM8 activation. Conclusion : Overall, we report DNA methylation changes in recurrent GBM, and suggest the involvement of TEM8 in the progression of GBM.
A flea beetle can stick a perfect landing
Authors: Zong Le , Wu Jianing , Yang Pingping , Ren Jing , Shi Guanya , Ge Siqin , Hu David L. 
Published: March 2022

Abstract
When we flip a coin, we expect a 50 percent chance of it landing on heads. But what happens when an insect jumps? In this study, we report the self-righting strategy of the flea beetle, Altica cirsicola, which lives in a dense maze of leaves. How can the flea beetle coordinate landing on surfaces of such a range of orientation and position? In this experimental study, we film the take-off, flight, and landing of flea beetles on a configurable angled platform. Dead flea beetles tossed through the air have a 46% chance of landing on their legs, similar to a fair coin. However, live beetles land successfully 85% of the time, suggesting the importance of active self-righting strategies to accommodate the different orientations of the landing platform. We observe that beetles may extend their wings to slow down and reduce impact as well as perform numerous rotations. These behaviors may inspire jumping robots that can land softly.
The Frequency and Prognostic Significance of ABO/Rh Blood Groups in Male Breast Cancer Patients: A Multi-center Study
Authors: Dogan Izzet , Ayhan Murat , Gurbuz Mustafa , Kucukarda Ahmet , Aydin Esra , Urun Yuksel , Cicin Irfan , Saip Pinar 
Published: March 2022

Abstract
Purpose: The study evaluated the distributions and prognostic significance of ABO and rhesus (D) groups in MBC patients.Patients and methods: The data of 137 patients were retrospectively reviewed. Clinical, histopathological data and ABO/Rh blood groups of the patients were recorded. The ABO/Rh blood group distributions were compared to the healthy men control group (n:120,160) by the chi-square test. Results: Overall distributions of ABO blood groups were different between the patients (17.5% AB, 38% A, 19% B, 25.5% O) and control group (7.88% AB, 42.06% A, 15.22% B, 34.84% O) (p<0.001). There were significant differences between the patients and control group with respect to AB vs. nonAB blood group distributions (p<0.001, Odds Ratio: 2.43 CI 95%) and O vs. nonO blood group distributions (p=0.016, Odds Ratio: 0.62 CI 95%). However, A vs. nonA and B vs. nonB blood group distributions were not significantly different. The distribution of the Rh factor was similar between patients and the control group (p=0.93). In univariate analysis, ABO/Rh blood groups were not a prognostic factor on OS (p=0.29).Conclusions: The frequency of the AB blood group in MBC patients is increased than in the healthy control group. AB blood group may be a risk factor for MBC, whereas O blood group may be a protective factor.
Narrow funnel-like interaction energy distribution is an indicator of specific protein interaction partners
Authors: Choi Juyoung 
Published: March 2022

Abstract
Biological mechanisms comprise protein interaction networks. However, most protein interaction predictions are based on interspecies biological evidence. These knowledge-based predictions are biased and have limited predictive ranges. Moreover, protein interaction prediction using in silico docking exhibits low accuracy for weak interactions and requires high computational power. This study suggests a novel method to identify protein interaction using interaction energy distribution. Protein interactions with specific partners can be predicted by searching narrow funnel-like interaction energy distribution. Kinases and E3 ubiquitin ligase are important signaling components. However, because their interactions vary and are weak, the interaction predictions are highly limited. However, this study shows that their interaction can be identified by analyzing interaction energy distribution with high accuracy and low computational cost. Furthermore, other specific protein interactions have significantly narrower funnel-like interaction energy distribution than those of noninteracting protein pairs.
Maternal Mortality Study in the Eastern Democratic Republic of the Congo
Authors: Ramazani Bin Eradi Imani , Ntela Simon-Decap Mabakutuvangilanga , Ahouah Mathieu , Ishoso Daniel Katuashi , Rothan-Tondeur Monique 
Published: March 2022

Abstract
Background: Affordable, quality health care for pregnant women can improve their health. Thus, performance-based financing (PBF) remains one of the outcomes for improving the health system and increasing the accessibility of the poorest pregnant women to health care and reducing the maternal mortality rate. However, there is no up-to-date data on maternal mortality in the health structures using PBF in the Democratic Republic of the Congo (DRC). This study measures the mortality rate among pregnant women in health facilities by applying the PBF approach and identifies the associated risk factors.Methods: This analytical epidemiological study was based on rétrospective data materna deaths recorded in 59 health facilities, using the PBF approach in three health zones in the southern part of Maniema province in east DRC. The study was conducted from July 1, 2015 to June 30, 2020. Descriptive, bi and multivariate analyses were used.Results: The maternal mortality rate was estimated at 620 deaths per 100,000 live births, of which 46% of maternal deaths were related to a parturients’ delayed decision in seeking healthcare in time (first delay). Maternal deaths were significantly associated with extreme ages (≤19 years and ≥40 years: p = <0.001), patient parity (in primigravidas and in large multiparas: p = 0.001), complications such as hemorrhagic, (p = <0.001), uterine ruptures:(p = <0.001), infections, (p = <0.001), and dystocia (p = <0.001).Conclusion: Despite the establishment of the PBF approach in this part of eastern DRC, women continue to lose their lives when they decide to give birth. The results imply that it is imperative to strengthen both women and health professionals’ knowledge about pregnancy and maternal health and their power to reduce instances of first delay by supporting women in formulating their birth plans
Moving beyond referrals to strengthen late-life depression care: a qualitative examination of primary care clinic and community-based organization partnerships
Authors: Wagner Jenny L , Henderson Stuart , Hoeft Theresa , Gosdin Melissa , Hinton Ladson 
Published: March 2022

Abstract
BackgroundNational guidelines have called for greater integration of primary care and behavioral health services, with more recent attention to social care and community-based services. Under growing resource constraints healthcare organizations have tended to rely on referrals to external entities to address social care needs. Traditional referral models, however, may not be equipped to provide for the complex needs of older adults with depression. The Care Partners Project was designed to strengthen late-life depression care through integrated partnerships between primary care clinics and community-based organizations. We sought to understand how these integrated partnerships, with shared tasks and accountability across organizations, changed the nature of depression care for older adults. MethodsWe conducted 65 in-depth, semi-structured interviews and six focus groups with service providers involved in the project, including care managers, primary care providers, and psychiatric consultants, and applied inductive and deductive qualitative thematic analysis to develop themes around participants’ experiences with the partnered initiative. ResultsWe found the partnerships established by the Care Partners Project reshaped late-life depression care in two ways: (1) bidirectional communication across organizations facilitated greater recognition among providers of intersecting medical and social needs associated with late-life depression; and (2) depression care became more coordinated and effective as care teams established or strengthened relationships across organizations. ConclusionsThese findings highlight the ways cross-organizational health and social care partnerships that move beyond traditional referrals can strengthen late-life depression care and enhance organizational capacities.
Finchite, Sr(UO2)2(V2O8)·5H2O, a new uranyl sorovanadate with the francevillite anion topology
Authors: Spano Tyler L. , Olds Travis A. , Hall Susan M. , Van Gosen Bradley S. , Kampf Anthony R. , Burns Peter C. , Marty Joe 
Published: March 2022

Abstract
Finchite (IMA2017-052), Sr(UO2)2(V2O8)·5H2O, is the first uranium mineral known to contain essential Sr. The new mineral occurs as yellow-green blades up to ~10 µm in length in surface outcrops of the calcrete-type uranium deposit at Sulfur Springs Draw, Martin County, Texas, U.S.A. Crystals of finchite were subsequently discovered underground in the Pandora mine, La Sal, San Juan County, Utah, U.S.A., as diamond-shaped golden-yellow crystals reaching up to 1 mm. The crystal structure of finchite from both localities was determined using single-crystal X-ray diffraction and is orthorhombic, Pcan, with a = 10.363(6) Å, b = 8.498(5) Å, c = 16.250(9) Å, V = 1431.0(13) Å3, Z = 4 (R1 = 0.0555) from Sulfur Springs Draw; and a = 10.3898(16), b = 8.5326(14), c = 16.3765(3) Å, V = 1451.8(4) Å3, Z = 4 (R1 = 0.0600) from the Pandora mine. Electron-probe microanalysis provided the empirical formula (Sr0.88K0.17Ca0.10Mg0.07Al0.03Fe0.02)Σ1.20(UO2)2(V2.08O8)·5H2O for crystals from Sulfur Springs Draw, and (Sr0.50Ca0.28Ba0.22K0.05)Σ0.94(U0.99O2)2(V2.01O8)·5H2O for crystals from the Pandora mine, based on 17 O atoms per formula unit. The structure of finchite contains uranyl vanadate sheets based upon the francevillite topology. Finchite is a possible immobilization species for both uranium and the dangerous radionuclide 90Sr because of the relative insolubility of uranyl vanadate minerals in water.
Ideologias partidárias e aplicação do fundo público: um estudo dos municípios da Região Funcional 7/RS/Brasil
Authors: Rotta Edemar , Lago Ivann Carlos , Lima Daniela Morais de , Smolski Felipe Micail da Silva , Rossini Neusa 
Published: March 2022

Este artigo aborda a relação entre as ideologias partidárias e a aplicação do fundo público em políticas sociais. Busca auxiliar na compreensão dos processos de aplicação do fundo público disponível aos municípios a partir das políticas de descentralização do Estado. Analisa possíveis correlações entre as opções políticas dos chefes de executivos municipais, a destinação de recursos do orçamento público para as políticas sociais e indicadores de desenvolvimento dos municípios. Tem como referência a abordagem dialética, trabalhando com dados secundários obtidos junto à Secretaria do Tesouro Nacional, Tribunal Superior Eleitoral e Fundação de Economia e Estatística do Estado do Rio Grande do Sul. Trabalha com os 77 municípios da Região Funcional 7, dos Conselhos Regionais de Desenvolvimento (COREDES/RS), no período de 2005 a 2016. Constata-se que há predominância dos partidos de direita nas gestões municipais; os partidos de esquerda ampliaram sua presença; os partidos de centro são os que menos aplicam em políticas sociais; a variável opção partidária dos detentores de mandato executivo se faz mais intensa nas áreas em que há maior liberdade na aplicação dos recursos, ou que sejam mais dependentes de articulação com outras esferas da federação para a obtenção de recursos, como os casos da habitação, urbanismo, saneamento básico e cultura; existem correlações evidentes entre a ampliação dos valores aplicados em políticas sociais e a melhoria dos indicadores de desenvolvimento, constatadas de forma positiva forte para 56 municípios; positiva moderada em 12; positiva fraca em 3; negativa fraca em 4; e negativa moderada em 2 municípios.
Desenvolvimento e Políticas Sociais: Uma Análise Comparativa dos Indicadores em Minas Gerais (2000-2010)
Authors: Caetano Rafaela Maiara , Pereira Samanta Borges , Murad Elisa Pereira , Silva Sabrina Soares da , Antonialli Luiz Marcelo 
Published: March 2022

Este artigo aborda o tema do desenvolvimento no que se refere à urgência de suplantar o conceito como sinônimo de crescimento, para superar os agravamentos dos problemas advindos dessa concepção. O objetivo foi verificar se os investimentos em políticas sociais provocaram mudanças no bem-estar social dos municípios mineiros entre 2000 e 2010. Através do software SPSS e com base nos dados obtidos pelo Instituto Brasileiro de Geografia e Estatística (IBGE) e no Atlas do Desenvolvimento Humano, foram realizadas análises para os 853 municípios do Estado de Minas Gerais, através do Índice de Bem-Estar Social (IBES), composto por sub índices (saúde e saneamento, educação, e aspectos econômicos). O referencial teórico baseou-se nas discussões sobre desenvolvimento social e sustentável (VEIGA, 2001; SACHS, 2004, 2008), políticas públicas sociais (SERAFIM; DIAS, 2012; CASTRO; OLIVEIRA, 2014; DOWBOR, 2018) e IDH (GUIMARÃES; FEICHAS, 2009). A metodologia dividiu-se em duas etapas. Os resultados demonstram que os gastos em saúde e saneamento, habitação e previdência social foram os que tiveram maior impacto sobre o IBES, demonstrando que investimentos governamentais geram mudanças significativas para a população.Os resultados encontrados reforçam as discussões acerca do papel do desenvolvimento, que deve corresponder à expansão das potencialidades humanas e não apenas de bens de consumo (VEIGA, 2001) e deve ser visto como um processo que reduz as distâncias sociais que separam as diferentes camadas da população (SACHS, 2004).
Responses of soil microorganisms to simulated climate change in desert grassland in northern China
Authors: Zhang Yi , Xie Ying-Zhong , Ma Hong-Bin , Zhang Juan , Jing Le , Wang Yu-Tao , Li Jian-Ping 
Published: March 2022

Abstract
The study evaluates how simulated climate change affects microorganism communities in the desert grassland of Ningxia Autonomous Region, China. It explores the soil microorganism community and relationships among the soil microorganism community, chemical properties, soil respiration (SR), and plant biomass under climate change. We established a field experiment with five levels of rainfall using rainout shelters and two levels of temperature by the Open-Top Chamber (OTC). The results show that in fungal communities, normal precipitation will promote the number and base number of valid sequences the most, and R66 will significantly promote the mean length of the valid sequence. In the bacterial communities, the interaction of increasing temperature and R133 will promote the number of valid sequences and R166 will promote the length of valid sequences. Neither rainfall nor rising temperature promotes not only the soil community α-diversity but also the soil microorganism community β-diversity. Soil microorganism communities show resistance to rainfall. SR will limit the soil microorganism diversity. Soil organic carbon (SOC), soil total nitrogen (STN), and soil total phosphorus (STP) will promote soil microorganism abundance (SMA) and soil microorganism diversity (SMS). Aboveground living biomass (ALB) and soil temperature (ST) will promote soil α-diversity, whereas the effect of root biomass (RB) on the soil α-diversity is the opposite.
Mapeamento de áreas degradadas pela mineração de ouro através de técnicas de sensoriamento remoto ao longo do rio revue – Moçambique.
Authors: Raso Edson Fernandes , Augusto Machava Castigo Davi , Sozinho Nhongo Eufrásio João 
Published: March 2022

O mineral de ouro no distrito de Manica é extraído ao longo do rio Revué. As intensas actividades de extração e processamento deste mineral tem criado alterações nas classes de uso e cobertura de terras das áreas em que são praticadas as actividades garimpo. Vários estudos estão sendo desenvolvidos sobre os impactos negativos da mineração artesanal de ouro neste distrito sobre meio ambiente, não abordando variação das classes de uso de cobertura. Este trabalho visa mapear áreas degradadas pela mineração entre os anos de 2000 a 2019 na microbacia do Revue, estimando a quantidade de vegetação nativa suprimida. Para alcançar os objetivos propostos, foi realizado o mapeamento do uso e cobertura da terra através da classificação supervisionada e pelo cálculo do Índice de Vegetação por Diferença Normalizada de imagens de satélite Landsat 05 e Landsat 08 (OLI). As imagens foram pré-processadas e classificadas pelos Sistemas de Informação Geográfica (SPRING 5.5.2, ArcGIS 10.2.1 e QGIS 3.2.3). Os resultados mostraram que o atual padrão de uso e ocupação da terra é marcadamente caracterizado pela presença de áreas de mineração artesanal, industrial e pelo plantio de eucaliptos e pinheiros que se expandem em direção a áreas de vegetação nativa e de solo exposto.
Phyto-targeting the CEMIP Expression as a Strategy to Prevent Pancreatic Cancer Metastasis
Authors: Periyasamy Loganayaki , Muruganantham Bharathi , Park Woo-Yoon , Muthusami Sridhar 
Published: March 2022

Introduction:Metastasis of primary pancreatic cancer (PC) to adjacent or distant organs is responsible for the poor survival rate of affected individuals. Chemotherapy, radiotherapy, immunotherapy is being prescribed currently to treat PC in addition to surgical resection. Surgical resection is the preferred treatment for PC that leads to 20% of 5-year survival, but only less than 20% of patients are eligible for surgical resection, because of the poor prognosis. To improve the prognosis and clinical outcome, early diagnostic markers need to be identified, and targeting them would be of immense benefit to increase the efficiency of the treatment. Cell migration inducing hyaluron binding protein (CEMIP) is identified as an important risk factor for the metastasis of various cancers including PC. Emerging studies point out the crucial role forCEMIP in the regulation of various signaling mechanismleading to enhanced migration and metastasis of PC.Methods:The published findings in the area of pancreatic cancer metastasis, phyto-constituents and CEMIP were retrieved from Pubmed, Sciencedirect, Cochrane library. Computational tools such as gene expression profiling interactive analysis (GEPIA) and Kaplan–Meier (KM) plotter were used to study the relationship between CEMIP expression and survival of PC individuals.Results:Gene expression analysis using GEPIA database identified a stupendousincrease in the CEMIP transcript in PC when compared with adjacent normal tissue. KM plotter analysis revealed a critical role for CEMIP on the overall survival (OS) and disease-free survival (DFS) among PC patients. Subsequently several risk factors associated with the development of PC were screened and analyzed its ability to regulate CEMIP gene expression using computational tools.Conclusion:The current review is focused on gathering information about the regulatory role of phytocomponents on PC migration and exploring their possible impact on the CEMIP expression.
Polymorphism Rs2421943 of the Insulin-Degrading Enzyme Gene and the
Risk of Late-Onset Alzheimer’s Disease
Authors: Šerý Omar , Zeman Tomáš , Hálová Alice , Janout Vladimír , Janoutová Jana , Lochman Jan , Balcar Vladimir J. 
Published: March 2022

Background:
Insulin-degrading enzyme (IDE) is a widely distributed Zn2+-binding metalloprotease
that cleaves multiple short and medium-sized peptides prone to form β-structures. These
include insulin and amyloid-β peptides. Accumulation and fibrillation of amyloid-β peptides leading
to the formation of amyloid plaques is a characteristic sign of Alzheimer’s disease (AD) pathology.

Objective:
The study investigated the rs2421943 single nucleotide polymorphism (SNP) of the IDE
gene as a risk factor for MCI (mild cognitive impairment) and AD.

Methods:
Two independent groups of 1670 patients and controls were included. The AD group consisted of 595 patients and 400 controls; the MCI group involved 135 patients and 540 matched controls. PCR and restriction fragment length analysis was used for analysis of the rs2421943 polymorphism. Using the miRBase and RNA22 prediction tools in silico indicated that the rs2421943 polymorphism is a potential target for a specific miRNA (hsa-miR-7110-5p).

Results:
AG and GG genotypes of rs2421943 significantly increased the risk of AD, and the AG genotype
increased the risk of MCI. It seems the G allele both increases the risk of AD and accelerates the
transition through the MCI phase. In silico study revealed that rs2421943 is inside the sequence binding
miRNA hsa-miR-7110-5p. The polymorphism could affect the rate of IDE pre-RNA (heterogeneous
nuclear RNA, hnRNA) processing, resulting in slower translation, lower levels of IDE, deficient
removal of amyloid-β fragments, and greater risk of and/or accelerated progression of AD.

Conclusions:
GG and AG genotypes of the single nucleotide polymorphism rs2421943 of insulindegrading
enzyme gene increase the risk of AD and MCI.
Exploring the Potentials of Phytochemicals for Targeting Coronavirus
Authors: Khanna Shirin , Ganesan Aravindhan , Kalyaanamoorthy Subha 
Published: March 2022

Abstract:
Since the initial outbreak in December 2019, the COVID-19 pandemic caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to more than 3 million deaths
worldwide. There is an urgent need for developing a potential therapy against SARS-CoV-2. Exploring
the potentials of phytochemicals towards inhibition of SARS-CoV-2 proteins remains of significant
scientific interest. The therapeutic values of phytochemicals in the treatment of diseases, such as
viral infections, are known for a long time. In this review, we present a brief overview of the past experimental
and computational efforts on evaluating phytochemicals against SARS coronaviruses, an
earlier coronavirus strain. We discuss natural metabolites of different structural and chemical scaffolds,
including polyphenols, flavonoids, and phytosterols, which can be promising compounds for
screening against the currently evolving SARS-CoV-2 virus.