bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Bahan Ajar Biologi Berbasis Flipbook Maker Dipadu dengan Model Problem Based Learning pada Materi Sel untuk Siswa Kelas XI SMA
Authors: Barnett Elisabeth , Arifin As’ad Syamsul 
Published: December 2022

The purpose of the development in this research is to develop Flipbook Maker-Based Biology Teaching Materials Combined with Problem Based Learning (PBL) Models in Cell Materials of Class XI High School Students. This type of research is development research. The development model used is a R&D development model consisting of 5 stages Namely data collection (information collection), planning, preliminary field testing (preliminary field testing), product revision (Dwiantoro & Kusumandari, 2016). The results of the research were given by material experts with a percentage of 92.85% with a very valid category, while research from a media expert lecturer with a percentage of 83.69% with a fairly valid category and an assessment of 10 students with a percentage of 93.33% and declared very valid. Based on the results of the assessment obtained, it can be concluded that the flipbook maker-based biology teaching materials are combined with the problem-based learning (PBL) model so that it can increase students' interest in learning this can be seen from the approach used including quantitative and qualitative approaches with data analysis techniques in the form of questionnaires. The response from the representatives of 10 students and the results obtained was a percentage of 93.33%, then the teaching material was declared "very valid" so that it could be tested.
Pengembangan Bahan Ajar dengan Penguatan Karakter pada Materi Bangun Ruang untuk Sekolah Dasar
Authors: Rachma Rachmawati , Wijayanti Rina , Anugraini Asri Putri 
Published: December 2022

The purpose of this study to produce learning materials based character building. Character building refers to the PPK where there are five main character that come from Pancasila, namely religion, nationalism, integrity, independence and mutual cooperation. At the elementary education level, the portion of character building provided is greater than knowledge. This underlies researchers to develop learning materials based on character building. Learning materials contain material with strengthening character building, and student activity columns that aim to explore knowledge by inserting strengthening character education and question exercises
This is a development research. The development procedure refers to the ADDIE development model (Analyze, Design, Develop, Implementation and Evaluation). The research begins with Analyze, which is needs analysis through observation and interviews, then design is designing teaching materials. The next stage is develope, which is developing with validation to experts, then followed by the implementation stage, namely by implementing trials of teaching materials to students with the teacher. The last step is evaluation, namely conducting an evaluation after the implementation of teaching materials. Instruments in the form of expert validation sheets (material and media experts), test questions and student interview sheets. The results of the validation of the teaching materials developed show that the category is feasible in terms of validity, practicality, and effectiveness.
SubSurface Flow-Wetlands dengan Tanaman Air untuk Menurunkan Kadar COD pada Limbah Cair Tahu
Authors: Munawwaroh Anita , Lestari Endang Sri 
Published: December 2022

Karakteristik limbah cair industri tahu umumnya mengandung zat organik tinggi. Kandungan zat organik dapat menyebabkan pertumbuhan mikroba dalam air secara cepat. Sehingga akan mengakibatkan kadar oksigen dalam air menurun tajam dan kadar COD tinggi. Untuk itu diperlukan sistem pengolahan air limbah yang murah dan efisien agar dapat mengatasi permasalahan tersebut dengan menggunakan SubSurface Flow-Wetlands. Penelitian ini bertujuan untuk mengetahui pengaruh SSF-Wetlands dengan tanaman Eichhornia crassipes dan Pistia stratiotes L. dalam menurunkan kadar COD pada limbah cair tahu. Prosedur penelitian ini antara lain (1) Tahap Pengambilan sampel yaitu sampel limbah cair tahu dan sampel tanaman eceng gondok dan kayu apu. 2) Tahap Pembuatan SSF-Wetlands, (3) Tahap pengolahan limbah dengan SSF-Wetlands dan tanaman air. (4) Tahap pengujian COD. Kemudian data dianalisis menggunakan ANOVA satu arah. Hasil penelitian ini diperoleh kadar COD awal pada limbah cair tahu sebesar 12.500 mg/L. Namun, limbah cair tahu yang diolah menggunakan SSF-Wetlands dengan tanaman air mampu menurunkan kadar COD sampai 10.000 mg/L. Penurunan kadar COD tersebut disebabkan bahan padatan mulai mengendap sehingga bahan buangan di air limbah juga berkurang. Selain itu, sebagian bahan buangan telah teroksidasi dan sebagian lagi juga telah terserap oleh tanaman sehingga mengurangi kadar COD. Berdasarkan hasil uji Duncan menunjukkan bahwa tidak ada perbedaan yang nyata pada perlakuan A1, A2 dan A3. Namun, perlakuan tersebut berbeda nyata dengan perlakuan A4. Dimana perlakuan SSF-Wetland dengan eceng gondok dan kayu apu (A4) menghasilkan kadar COD yang lebih tinggi dibandingkan dengan perlakuan yang lainnya yaitu sebesar 2420 mg/L.
Baseline robot-measured kinematic metrics predict discharge rehabilitation outcomes in individuals with subacute stroke
Authors: Goffredo Michela , Proietti Stefania , Pournajaf Sanaz , Galafate Daniele , Cioeta Matteo , Le Pera Domenica , Posteraro Federico , Franceschini Marco 
Published: December 2022

Background:The literature on upper limb robot-assisted therapy showed that robot-measured metrics can simultaneously predict registered clinical outcomes. However, only a limited number of studies correlated pre-treatment kinematics with discharge motor recovery. Given the importance of predicting rehabilitation outcomes for optimizing physical therapy, a predictive model for motor recovery that incorporates multidirectional indicators of a patient’s upper limb abilities is needed.Objective:The aim of this study was to develop a predictive model for rehabilitation outcome at discharge (i.e., muscle strength assessed by the Motricity Index of the affected upper limb) based on multidirectional 2D robot-measured kinematics.Methods:Re-analysis of data from 66 subjects with subacute stroke who underwent upper limb robot-assisted therapy with an end-effector robot was performed. Two least squares error multiple linear regression models for outcome prediction were developed and differ in terms of validation procedure: the Split Sample Validation (SSV) model and the Leave-One-Out Cross-Validation (LOOCV) model. In both models, the outputs were the discharge Motricity Index of the affected upper limb and its sub-items assessing elbow flexion and shoulder abduction, while the inputs were the admission robot-measured metrics.Results:The extracted robot-measured features explained the 54% and 71% of the variance in clinical scores at discharge in the SSV and LOOCV validation procedures respectively. Normalized errors ranged from 22% to 35% in the SSV models and from 20% to 24% in the LOOCV models. In all models, the movement path error of the trajectories characterized by elbow flexion and shoulder extension was the significant predictor, and all correlations were significant.Conclusion:This study highlights that motor patterns assessed with multidirectional 2D robot-measured metrics are able to predict clinical evalutation of upper limb muscle strength and may be useful for clinicians to assess, manage, and program a more specific and appropriate rehabilitation in subacute stroke patients.
An analysis of the harassments and challenges faced by the public transport users in a developing country of South Asia
Authors: Yasir Samnun , Ahmad Tanzim , Enam Annesha 
Published: December 2022

Bangladesh—located in south Asia and home to almost 167 M people, is one of the most densely populated countries in the world. Despite high population density, the country is yet to have a well-coordinated mass transit system. However, most people rely on public transportation due to comparatively low motorization. Public transport users, especially vulnerable cohorts (e.g., women), face enormous challenges, including molestations, assaults, and rape during their daily commute. Few studies that analyzed the state of harassment exclusively focused on women, which might not be comprehensive enough to understand the state of the problem and devise effective policies. Therefore, the current study explores the state of harassment in the three cities of Bangladesh, namely, Dhaka—the capital; Rajshahi; and Mymensingh across all genders. The study also investigates people’s perception of women’s mobility, the experience of using public transport, and the desirable safety precautions to understand the gender differences and the variability across the three cities. A detailed questionnaire survey was conducted to collect data from the three cities. The study found considerable gender differences regarding the perception of women’s mobility hindrances, the experience of using public transportation, and desirable safety precautions. The differences across the three cities were also noticeable. Contrary to the general belief, the study found that people from smaller towns like Mymensingh were more likely to get harassed than those from the bigger cities like Dhaka and Rajshahi—insinuating the lack of reporting from the smaller towns of the country. The findings from the study could be helpful for the transit and city planners in creating a conducive transit ambiance in Bangladesh. Based on the desirable safety precautions, female-only rides, especially at night, would be beneficial. City planners could also plan small and medium business activities around transit stops to attract the crowd and reduce the possibility of getting harassed while walking alone to access transit.
CYP2C19 genotype and platelet aggregation test-guided dual antiplatelet therapy after off-pump coronary artery bypass grafting: A retrospective cohort study
Authors: Yao Haoyi , Qin Kaijie , Liu Yun , Yang Yi , Zhu Jiaxi , Chen Anqing , Wang Zhe , Ye Xiaofeng , Zhou Mi , Li Haiqing , Qiu Jiapei , Zhao Qiang , Zhu Yunpeng 
Published: December 2022

BackgroundDual antiplatelet therapy (DAPT) is recommended in patients undergoing off-pump coronary artery bypass graft surgery (OPCAB). Clopidogrel is less effective among patients with loss-of-function (LoF) of CYP2C19 alleles, while ticagrelor has direct effects on P2Y12 receptor. Whether a CYP2C19 genotype plus platelet aggregation test (PAgT)-guided DAPT after CABG could improve clinical outcomes remain uncertain.Materials and methodsFrom August 2019 to December 2020, 1,134 consecutive patients who underwent OPCAB received DAPT for 1 year after surgery in Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. According to the actual treatment they received in real-world, 382 (33.7%) of them received a traditional DAPT: aspirin 100 mg qd + clopidogrel 75 mg qd, no matter the CYP2C19 genotype and response in platelet aggregation test (PAgT). The other 752 (66.3%) patients received an individual DAPT based on CYP2C19 genotype and PAgT: aspirin 100 mg qd + clopidogrel 75 mg qd if CYP2C19 was extensive metabolizer, or moderate metabolizer but normal response in PAgT; aspirin 100 mg qd + ticagrelor 90 mg bid if CYP2C19 was poor metabolizer, or moderate metabolizer but no or low response in PAgT. One-year follow-up was achieved for all patients. The primary outcome was major adverse cardiovascular events (MACE), a composite of cardiovascular death, myocardial infarction, and stroke. The safety outcome was thrombolysis in myocardial infarction (TIMI) criteria major bleeding.ResultsCompared with the traditional DAPT group, the risk of MACE in the individual DAPT group was significantly lower (5.5 vs. 9.2%, HR 0.583; 95% CI, 0.371–0.915; P = 0.019), mainly due to the decreased risk of MI (1.7 vs. 4.2%, HR 0.407; 95% CI, 0.196–0.846; P = 0.016). The risk of TIMI major bleeding events was similar between the two groups (5.3 vs. 6.0%, RR 0.883; 95% CI, 0.537–1.453; P = 0.626).ConclusionFor patients who underwent OPCAB, individual DAPT (CYP2C19 genotype plus PAgT-guided strategy) was associated with a lower risk of MACE and a similar risk of major bleeding.
Plasma metabolomic analysis reveals the therapeutic effects of Jiashen tablets on heart failure
Authors: Miao Xinglong , Chen Jiaping , Su Yangyan , Luo Jiayi , He Yi , Ma Jiang , He Xin 
Published: December 2022

BackgroundHeart failure is a chronic progressive condition that significantly affects the quality of life of patients with high hospitalization and mortality rates. Jiashen tablets (JST), a Chinese herbal formula, have been reported to be an effective treatment against heart failure, however the underlying mechanisms remain obscure. This study was designed to determine the effect of JST on the treatment of heart failure and delineate the underlying mechanisms by an untargeted metabolomics approach.Materials and methodsThe chronic heart failure model was established by the permanent ligation of the left anterior descending coronary artery in rats. The cardiac functions of rats, including left ventricular ejection fraction (LVEF) and fractional shortening (LVFS), left ventricular internal diameter end diastole (LVIDd) and end systole (LVIDs), and interventricular septum thickness in diastole (IVSd) and in systole (IVSs), were measured by echocardiography. Biochemical analysis and histopathological examination were also performed to evaluate therapeutic effects of JST for treating heart failure. UHPLC-QTOF-MS/MS coupled with multivariate statistical analyses were applied for plasma metabolic profiling to identify biomarkers and potential mechanisms of JST in the treatment of heart failure.ResultsJiashen tablets could improve the cardiac function of heart failure rats and thus ameliorate heart failure via enhancing rat LVEF and LVFS and decreasing LVIDd, LVIDs, IVSd, and IVSs. Results of biochemical analysis and histopathological examination revealed that JST could reduce the serum lactate dehydrogenase (LDH) activity and the level of NT-pro BNP, markers of heart failure and myocardial damage, and inhibit myocardial fibrosis. Furthermore, in metabolomics analysis, a total of 210 metabolites with significant differences were identified between heart failure rats and normal rats, among which 29 metabolites were significantly restored after JST treatment. These metabolites were primarily involved in tryptophan metabolism, branched-chain amino acid metabolism, fatty acids β-oxidation, and glycerophospholipid metabolism.ConclusionThe present study illustrated the therapeutic effect of JST for the treatment of heart failure and delineated the underlying mechanisms mainly relating to the regulation of amino acid metabolism and lipid metabolism in heart failure rats.
Sex differences in one-year recurrence and all-cause mortality following catheter ablation of ventricular tachycardia in structural heart disease
Authors: Tóth Patrik , Komlósi Ferenc , Vámosi Péter , Arnóth Bence , Szegedi Nándor , Salló Zoltán , Piros Katalin , Perge Péter , Osztheimer István , Ábrahám Pál , Széplaki Gábor , Merkely Béla , Gellér László , Nagy Klaudia Vivien 
Published: December 2022

AimsWe aimed to establish sex-specific predictors for 1-year VT recurrence and 1-year all-cause mortality in patients with structural heart disease undergoing catheter ablation.MethodsWe analyzed data of 299 patients recorded in our structured registry. These included medical history, echocardiography parameters, laboratory results, VT properties, procedural data.ResultsOut of the 299 patients, 34 (11%) were female. No significant difference was found between women and men in terms of VT recurrence (p = 0.74) or mortality (p = 0.07). In females, severe mitral regurgitation (MR), tricuspid regurgitation (TR), presentation with incessant VT, and preprocedural electrical storm (ES) were associated with increased risk of VT recurrence. Diabetes, implanted CRT, VT with hemodynamic instability, ES and advanced MR were the risk factors of mortality in women. ACEi/ARB use predicted a favorable outcome in both endpoints among females. In men, independent predictors of VT recurrence were the composite parameter of ES and multiple ICD therapies, presentation with incessant VT, severe MR, while independent predictors of mortality were age, LVEF, creatinine and previously implanted CRT.ConclusionAccording to our investigation, there are pronounced sex differences in predictors of recurrence and mortality following VT ablation.
Comparison of effectiveness and safety of high-power vs. conventional-power radiofrequency ablation for treatment of atrial fibrillation
Authors: Cui Penghui , Qu Yunpeng , Zhang Jichang , Wu Junduo , Zhang Jing , Shi Yongfeng , Liu Bin 
Published: December 2022

AimTo compare high-power (HP) vs. conventional-power (CP) radiofrequency ablation for atrial fibrillation (AF).MethodsWe retrospectively enrolled AF patients undergoing CP (30–40 W, 43 patients) or HP (50 W, 49 patients) radiofrequency ablation. Immediate pulmonary vein (PV) single-circle isolation, PV-ablation time, AF recurrence, AF recurrence-free survival, and complications were analyzed.ResultsDiabetes was more common in the CP group than in the HP group (27.91% vs. 10.20%, P = 0.029). The left PV single-circle isolation rate (62.79% vs. 65.31%), right PV single-circle isolation rate (48.84% vs. 53.06%), and bilateral PV single-circle isolation rate (32.56% vs. 38.78%; all P &gt; 0.05) did not differ between the groups. Single-circle ablation times for the left PVs (12.79 ± 3.39 vs. 22.94 ± 6.39 min), right PVs (12.18 ± 3.46 vs. 20.67 ± 5.44 min), and all PVs (25.85 ± 6.04 vs. 45.66 ± 11.11 min; all P &lt; 0.001) were shorter in the HP group. Atrial fibrillation recurrence within 3 months (13.95% vs. 18.37%), at 3 months (11.63% vs. 8.16%), and at 6 months after ablation (18.60% vs. 12.24%; all P &gt; 0.05) was similar in both groups. Atrial fibrillation recurrence-free survival did not differ between the groups (Kaplan-Meier analysis). Cardiac rupture and pericardial tamponade did not occur in any patient. Pops occurred in 2 and 0 patients in the HP and CP groups, respectively (4.08% vs. 0.00%, P = 0.533).ConclusionHigh-power ablation improved operation time and efficiency without increasing complications.
Changes in postoperative opioid prescribing across three diverse healthcare systems, 2010–2020
Authors: Coquet Jean , Zammit Alban , Hajouji Oualid El , Humphreys Keith , Asch Steven M. , Osborne Thomas F. , Curtin Catherine M. , Hernandez-Boussard Tina 
Published: December 2022

ObjectiveThe opioid crisis brought scrutiny to opioid prescribing. Understanding how opioid prescribing patterns and corresponding patient outcomes changed during the epidemic is essential for future targeted policies. Many studies attempt to model trends in opioid prescriptions therefore understanding the temporal shift in opioid prescribing patterns across populations is necessary. This study characterized postoperative opioid prescribing patterns across different populations, 2010–2020.Data SourceAdministrative data from Veteran Health Administration (VHA), six Medicaid state programs and an Academic Medical Center (AMC).Data extractionSurgeries were identified using the Clinical Classifications Software.Study DesignTrends in average daily discharge Morphine Milligram Equivalent (MME), postoperative pain and subsequent opioid prescription were compared using regression and likelihood ratio test statistics.Principal FindingsThe cohorts included 595,106 patients, with populations that varied considerably in demographics. Over the study period, MME decreased significantly at VHA (37.5–30.1; p = 0.002) and Medicaid (41.6–31.3; p = 0.019), and increased at AMC (36.9–41.7; p &lt; 0.001). Persistent opioid users decreased after 2015 in VHA (p &lt; 0.001) and Medicaid (p = 0.002) and increase at the AMC (p = 0.003), although a low rate was maintained. Average postoperative pain scores remained constant over the study period.ConclusionsVHA and Medicaid programs decreased opioid prescribing over the past decade, with differing response times and rates. In 2020, these systems achieved comparable opioid prescribing patterns and outcomes despite having very different populations. Acknowledging and incorporating these temporal distribution shifts into data learning models is essential for robust and generalizable models.
Cushing’s syndrome is associated with altered adipokine profile
Authors: Dadej Daniela , Szczepanek-Parulska Ewelina , Wrotkowska Elżbieta , Ruchała Marek 
Published: December 2022

IntroductionAdipokines are signaling molecules involved in the integration of metabolism. Changes in their concentrations were observed in obesity, metabolic syndrome, diabetes mellitus and cardiovascular diseases, as well as endocrine disorders. Cushing’s syndrome is associated with metabolic dysregulation, but the significance of adipokines in this entity and related complications is largely unknown. The aim of our study was to determine the concentrations of adipokines: fetuin A, fatty acid binding protein 4 (FABP4) and retinol binding protein 4 (RBP4) in Cushing’s syndrome and to assess their relation to established cardiovascular and diabetes risk markers.MethodsWe examined 21 subjects with Cushing’s syndrome and 24 healthy controls in a cross-sectional manner. Venous blood samples were analysed for adipokines, cortisol, adrenocorticotrophin, glucose, insulin, glycated haemoglobin (HbA1c), triglycerides, cholesterol fractions, thyrotropin and free thyroid hormones concentrations. Patients’ body mass index (BMI) was evaluated, homeostatic model assessment-insulin resistance and Systematic Coronary Risk Evaluation (SCORE) were calculated.ResultsWe found that the concentration of fetuin A was lower, while FABP4 and RBP4 concentrations were higher in Cushing’s syndrome compared to controls [156.4 ± 60.0 µg/ml vs 260.7 ± 49.6 µg/ml; 79.8 (35.2-156.1) ng/ml vs 27.9 (17.1-36.7) ng/ml and 34 (30-37.7) mg/l vs 25.8 (23.6-27.7) mg/l, respectively]. Fetuin A correlated inversely, while FABP4 and RBP4 positively, with the concentrations of urinary free cortisol and adrenocorticotrophin. Fetuin A was positively related to LDL-cholesterol, and negatively to SCORE and HbA1c. FABP4 was associated positively with BMI, HbA1c and triglycerides, while RBP4 correlated positively with triglycerides and systolic blood pressure.ConclusionsAdipokines’ concentrations change in hypercortisolism. Further research is needed to ascertain whether adipokines are involved in the development of metabolic complications accompanying Cushing’s syndrome or secondarily reflect metabolic dysregulation.