bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancer-driven gene regulatory networks inference from single-cell RNA-seq and ATAC-seq data
Authors: Li Yang , Ma Anjun , Wang Yizhong , Guo Qi , Wang Cankun , Chen Shuo , Fu Hongjun , Liu Bingqiang , Ma Qin 
Published: December 2022

ABSTRACTDeciphering the intricate relationships between transcription factors (TFs), enhancers, and genes through the inference of enhancer-driven gene regulatory networks is crucial in understanding gene regulatory programs in a complex biological system. This study introduces STREAM, a novel method that leverages a Steiner Forest Problem model, a hybrid biclustering pipeline, and submodular optimization to infer enhancer-driven gene regulatory networks from jointly profiled single-cell transcriptome and chromatin accessibility data. Compared to existing methods, STREAM demonstrates enhanced performance in terms of TF recovery, TF-enhancer relation prediction, and enhancer-gene discovery. Application of STREAM to an Alzheimer’s disease dataset and a diffuse small lymphocytic lymphoma dataset reveals its ability to identify TF-enhancer-gene relationships associated with pseudotime, as well as key TF-enhancer-gene relationships and TF cooperation underlying tumor cells.
PSYLLIUM FIBER PROTECTS MICE AGAINST WESTERN DIET-INDUCED METABOLIC SYNDROME VIA MICROBIOTA-DEPENDENT MECHANISM
Authors: Bretin Alexis , Gewirtz Andrew T. 
Published: December 2022

AbstractWe sought to identify semi-purified fibers that broadly promote gut and metabolic health and, moreover, identify the mechanisms by which they do so. Screening an array of purified fibers led us o appreciate that, of all fibers tested, psyllium was unique in that it strongly protected mice against both colitis and metabolic syndrome. Further investigation led us to appreciate that psyllium’s mechanism of action is quite distinct. Specifically, data we report in a manuscript under review indicates that low doses of psyllium protect mice against colitis via increasing serum bile acids that activate FXR. Here, we report that higher doses of psyllium protect mice against diet-induced obesity/metabolic syndrome by a FXR-independent mechanism that requires presence of at least a minimal microbiota.
Vector production via mental navigation in the entorhinal cortex
Authors: Neupane Sujaya , Fiete Ila , Jazayeri Mehrdad 
Published: December 2022

AbstractA cognitive map is a suitably structured representation that enables an agent to perform novel computations using prior experience, for instance planning a new route in a familiar space1,2. Recent work in mammals has found direct evidence for such structured representations in the presence of exogenous sensory inputs in both spatial3,4and non-spatial domains5–15. Here, we test a foundational postulate of the original cognitive map theory1,16that cognitive maps are recruited endogenously during mental navigation without external input. We recorded from the entorhinal cortex of monkeys in a mental navigation task that required animals to use a joystick to produce one-dimensional vectors between pairs of visual landmarks without sensory feedback about the intermediate landmarks. Animals’ ability to perform the task and generalize to new pairs indicated that they relied on a structured representation of the landmarks. Task-modulated neurons exhibited periodicity and ramping that matched the temporal structure of the landmarks. Neuron pairs with high periodicity scores had invariant cross-correlation structure, a signature of grid cell continuous attractor states17– 19. A basic continuous attractor network model of path integration20augmented with a Hebbian learning mechanism provided an explanation of how the system endogenously recalls landmarks. The model also made an unexpected prediction that endogenous landmarks transiently slow down path integration, reset the dynamics, and thereby, reduce variability. Remarkably, this prediction was borne out of a reanalysis of behavior. Together, our findings connect the structured activity patterns in the entorhinal cortex to the endogenous recruitment of a cognitive map during mental navigation.
Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant
Authors: Li Yaning , Shen Yaping , Hu Ziwei , Yan Renhong 
Published: December 2022

AbstractThe ongoing pandemic caused by a monkeypox virus (MPXV) variant has spread all over the world and raised great public health concerns. The DNA polymerase F8 of MPXV, associated with its processivity factors A22 and E4, is responsible for viral genome replication in the perinuclear sites of the infected cells as well as a critical target for developing antiviral drugs. However, the assembly and working mechanism for the DNA polymerase holoenzyme of MPXV remains elusive. Here, we present the cryo-EM structure of the DNA polymerase holoenzyme F8/A22/E4 from the 2022 West African strain at an overall resolution of 3.5 Å and revealed the precise spatial arrangement. Surprisingly, unlike any other previously reported B-family DNA polymerase, the holoenzyme complex is assembled as a dimer of heterotrimers, of which the extra interface between the thumb domain of F8 and A22 shows a clash between A22 and substrate DNA, suggesting an auto-inhibition state. Supplying an exogenous double-stranded DNA could notably shift the hexameric form into a trimeric form, which exposes the DNA binding site of thumb domain and might represent a more active state. The structures provide a molecular basis for the design of new antiviral therapeutics that target the MPXV DNA polymerase holoenzyme.
Impact of logistics performance on the store image, consumer satisfaction and loyalty: a quantitative case study
Authors: El Moussaoui Alaa Eddine , Benbba Brahim , El Andaloussi Zineb 
Published: December 2022

PurposeThe aim of this paper is to identify the impact of logistics performance on consumer satisfaction and store image in the retail context.Design/methodology/approachThe authors conducted a quantitative study with a sample of 201 consumers. The questionnaire is the instrument that was chosen to collect the data. Data processing was carried out using the statistical package for the social science (SPSS). The data analysis was conducted in two phases. The first phase consisted of testing the reliability and validity of the measurement scales. While the second phase of data processing consisted of testing the research hypotheses on the basis of data collected in the field.FindingsThe results of this research are as follows: consumer satisfaction positively affects their loyalty to the store. The results also indicate that store image affects the satisfaction of consumers. Indeed, “service quality” is often evaluated as a source of differentiation affecting consumer satisfaction. Concerning the effect of logistics performance on consumer satisfaction, the factor “product availability” was found to be the major factor affecting consumer satisfaction. A lack of logistics performance, in the context of retailing, negatively affects consumer satisfaction. On the other hand, when the consumer gets the right quantities at the right time, this can positively affect his satisfaction.Originality/valueAll studies carried out on this subject have presented an evaluation of the performance measures used in supply chain models. However, the results of these works were different in terms of performance measurement. It is difficult to specify the impact of logistics performance with only two variants (checkout level, and shelf level) in the retail context. Moreover, research related to this field in Morocco remains unexplored. In this context, it is necessary to explore the links between logistics performance, store image and consumer behavioral intentions in the Moroccan retailing context while taking into account three variants of logistics performance, which are: checkout level, shelf level and product disponibility.
Establishing underpinning concepts for integrating circular economy and offsite construction: a bibliometric review
Authors: Obi Lovelin , Arif Mohammed , Daniel Emmanuel I. , Oladinrin Olugbenga Timo , Goulding Jack Steven 
Published: December 2022

PurposeCircular economy (CE) and offsite construction (OSC) are two innovations for improving the construction industry's overall performance against a myriad of sustainability-driven agenda/initiatives. There is a real opportunity to conjoin OSC and CE to provide new insight and opportunities to deliver more evidence-based sustainable systems. This study analyses extant literature in CE and OSC (between 2000 and 2021) through a bibliometric review to tease out critical measures for their integration and transformation.Design/methodology/approachThis study adopts a science mapping quantitative literature review approach employing bibliometric and visualisation techniques to systematically investigate data. The Web of Science (WoS) database was used to collect data, and the VOSviewer software to analyse the data collected to determine strengths, weights, clusters and research trends in OSC and CE.FindingsImportant findings emerging from the study include extensive focus on sustainability, waste, life cycle assessment and building information modelling (BIM), which currently serve as strong interlinks to integrate OSC and CE. Circular business models, deconstruction and supply chain management are emerging areas, with strong links for integrating CE and OSC. These emerging areas influence organisational and operational decisions towards sustainable value creation, hence requiring more future empirical investigations.Originality/valueThis study is a novel research using bibliometric analysis to unpick underpinning conduits for integrating CE and OSC, providing a blueprint for circular OSC future research and practice. It provides the needed awareness to develop viable strategies for integrating CE in OSC, creating opportunities to transition to more sustainable systems in the construction sector.
Technological innovation in agri-food supply chains
Authors: Cricelli Livio , Mauriello Roberto , Strazzullo Serena 
Published: December 2022

PurposeThis study aims to analyse how the adoption of Industry 4.0 technologies can help different types of agri-food supply chains introduce and manage innovations in response to the challenges and opportunities that emerged following the COVID-19 pandemic.Design/methodology/approachA systematic literature review methodology was used to bring together the most relevant contributions from different disciplines and provide comprehensive results on the use of I4.0 technologies in the agri-food industry.FindingsFour technological clusters are identified, which group together the I4.0 technologies based on the applications in the agri-food industry, the objectives and the advantages provided. In addition, three types of agri-food supply chains have been identified and their configuration and dynamics have been studied. Finally, the I4.0 technologies most suited for each type of supply chain have been identified, and suggestions on how to effectively introduce and manage innovations at different levels of the supply chain are provided.Originality/valueThe study highlights how the effective adoption of I4.0 technologies in the agri-food industry depends on the characteristics of the supply chains. Technologies can be used for different purposes and managers should carefully consider the objectives to be achieved and the synergies between technologies and supply chain dynamics.
The financial, legal and political foundations of industrial resilience
Authors: Glew Rob , von Behr Carl-Magnus , Dreesbeimdiek Kaya , Houiellebecq Emma , Schumacher Roman , Rama Murthy Sudhir , Kumar Mukesh 
Published: December 2022

PurposeThis paper is motivated by the gap between the extensive academic discussion of industrial resilience and the limited resilience observed in response to large disruptions. Its purpose is to investigate the relationship between the industrial resilience of manufacturing and service operations and the resilience of the supporting financial, legal and political systems. This research identifies the impact of high or low levels of resilience in these supporting systems on the ability of industrial operations to perform as required in disrupted environments.Design/methodology/approachThe authors combine a multi-disciplinary literature review with empirical data from four exploratory case studies. First, the authors review the literature on resilience in the fields of operations management, finance, law and political science to bring the terminology and concepts of these fields closer together. This review also defines the independent variables of the study: financial, legal and political resilience. Second, the authors use the framework from the literature to analyse data from four case studies of operations in difference contexts and sectors.FindingsIndustrial resilience is interdisciplinary, nuanced and complex. High levels of industrial resilience require high levels of financial, legal and political resilience. However, the activities required to improve the resilience of these supporting systems are often outside the locus of control of operations managers. Multiple perspectives on resilience must be coordinated to strengthen the response of industrial operations to large disruptions.Research limitations/implicationsAs a conceptual and exploratory study, this paper does not utilise quantitative data or in-depth case studies. The authors demonstrate the importance of an interdisciplinary perspective on industrial resilience and provide a theoretical framework that can serve as a foundation to further studies of resilience. The review of the literature provides a glossary of definitions of resilience that improves clarity in this disparate field.Practical implicationsManagers can apply the findings of this work to start cross-functional discussions in their firms that recognise the multiple dimensions of industrial resilience and improve the resilience of the supporting systems. The exploratory case studies provide concrete guidance for how managers in the fields of humanitarian and development operations, healthcare and manufacturing can improve industrial resilience by considering the interaction with the supporting financial, legal and political systems.Originality/valueThis study is the first to provide detailed conceptual discussion and empirical evidence for the interdisciplinary nature of industrial resilience in the context of public sector and non-governmental organisations. Combining evidence from different contexts and sectors demonstrates the broad industrial value of this work.
A proposed circular-SCOR model for supply chain performance measurement in manufacturing industry during COVID-19
Authors: Ozbiltekin-Pala Melisa , Koçak Aydın , Kazancoglu Yigit 
Published: December 2022

PurposeCOVID-19 is a global event affecting supply chain operations and human health. With COVID-19, many issues in business models, business processes and supply chains, especially in the manufacturing industry, have had to change. The ability to analyze supply chain performances and ensure circularity in supply chains has become one of the factors whose importance has increased rapidly with COVID-19. Therefore, it aims to determine which supply chain performance criteria come to the fore for the company under consideration to accelerate the transformation into high performance and circularity in supply chains.Design/methodology/approachIn this study, a new circular-SCOR model is proposed, and 17 supply chain performance measurement criteria are prioritized for a manufacturing company in the context of circular economy principles during COVID-19 by using stepwise weight assessment ratio analysis and analytical hierarchy process method, separately.FindingsAs a result, for both methods, in the case study discussed, the demand fulfillment rate is determined as the most prominent criterion in line with the circular economy principles in the COVID-19 period in manufacturing supply chains.Originality/valueIt is expected that this study will contribute to managers and policy makers as it addresses the “new normal” that started after COVID-19 and the criteria to be considered in supply chain performance measurement and emphasizes the need to adopt circular supply chains, especially in manufacturing industries.
Farmer Business School participation and its impact on cocoa productivity and food security in Ghana
Authors: Owiredu Patrick , Wongnaa Camillus Abawiera , Acheampong Patricia Pinamang , Addison Monica , Agyei Adu Kwaku , Awunyo-Vitor Dadson 
Published: December 2022

PurposeVarious models and approaches are implemented to provide technical assistance and support to improve cocoa farmers' welfare in Ghana. The Farmer Business School (FBS), which is analogous to Farmer Field School (FFS), is one of the few initiatives of GIZ (Deutsche Gesellschaft für Internationale Zusammenarbeit) and Ghana Cocoa Board (COCOBOD). The main aim of the initiative is to train smallholder cocoa farmers to perceive cocoa production as a business. However, there is limited or conflicting evidence as to the effect of FBS on productivity and food security, especially in Ghana. This study assessed FBS participation and the participation's impact on productivity and food security of cocoa farmers.Design/methodology/approachThe study used primary data collected from 542 cocoa farmers in Central and Western North regions of Ghana and employed descriptive statistics, perception index and Endogenous Switching Regression (ESR) as analytical tools.FindingsThe results, which reported an overall perception index of 0.7, indicated that the farmers had a strong positive perception on the FBS program. The results also showed that sex of a farmer, number of years of formal education, farm size, extension contact, perception, distance to extension outlet and membership of farmer-based organizations (FBOs) significantly influenced the decision to participate in FBS program. Also off-farm income, years of education and household size significantly influenced farm productivity and household food security. The results further showed that participation in FBS improved productivity and food security of cocoa farmers.Research limitations/implicationsThe study used data from two regions of Ghana, namely the Central region and the Western North region. Findings from studies using data covering all cocoa growing areas of Ghana could be more informative in formulating policies aimed at encouraging participation in FBS and consequently help improve cocoa productivity and food security.Originality/valueThis article offers insights into the welfare effects of FBS on cocoa farmers as previous similar studies are without this information.
Leadership styles and employees commitment: the mediating role of job satisfaction
Authors: Oyewobi Luqman Oyekunle 
Published: December 2022

Purpose
This study aims to explore the relationship between three primary constructs: leadership styles, job satisfaction and organizational commitment among private-practice quantity surveyors in the Nigerian construction industry.

Design/methodology/approach
A questionnaire survey of 127 quantity surveying consultancy firms in Abuja was conducted using a quantitative research approach. A total of 76 acceptable questionnaires were returned from a total of 127 that were distributed, giving a response rate of approximately 60%. The data were analyzed using partial least square structural equation modelling.

Findings
Results showed a positive indirect link between leadership styles and organizational commitments, with job satisfaction acting as a partial mediator. It was also found through importance–performance map analysis, which is crucial for prioritizing managerial actions, that an employee’s commitment to a task is strongly influenced by that person’s level of job satisfaction.

Research limitations/implications
The study is quantitative and cross-sectional in nature, collecting information from a single source within an organization. A longitudinal strategy and a mixed methods approach should be used in future research.

Practical implications
Superiors/principal partners should make an effort to demonstrate a comprehensive understanding of leadership styles that is capable of enhancing job satisfaction and creating pleasant interaction in the work environment to increase the commitment of employees working in quantity surveying consultancy businesses.

Originality/value
As far as the author is aware, this study is one of the few to examine the impact of job satisfaction as a mediator between organizational commitments and leadership styles in the Nigerian construction industry. Furthermore, the study provides the basis for further discussion of the concepts offered in the paper.
Government support to Pakistani women entrepreneurs during the COVID-19 pandemic
Authors: Hussain Nida , Li Baoming , Sahibzada Habib Elahi 
Published: December 2022

PurposeUnder the unique context of COVID-19, this paper aims to analyze how the Government of Pakistan (GoP) provides financial and non-financial support to women entrepreneurs in Pakistan. Drawing on the resource-based theory of entrepreneurship (RBTE), the study advances the understanding of resources and grants offered by GoP to women entrepreneurs to help them in business survival.Design/methodology/approachThe study adopts qualitative research method to address the questions: how does the Pakistani government respond to issues faced by women entrepreneurs during the COVID-19 pandemic, and what assistance and initiatives were implemented by GoP? Semi-structured interviews were conducted with twenty on-job government officials related to the entrepreneurial sector in Pakistan.FindingsThe paper reveals that during the pandemic, GoP keenly communicated with women entrepreneurial representatives to comprehend their business challenges. In addition, waivers and incentives were provided to support their business activities. GoP further invited women entrepreneurs to contribute their knowledge and give suggestions in policy making.Originality/valueLots of research have been conducted to identify the issues faced by women entrepreneurs during the pandemic. However, the specific strategies, policies, and support provided by the governments to address these issues have often been overlooked. This paper fills such gap with focus on the governing bodies and policymakers in Pakistan towards women entrepreneurship during the COVID-19 crisis.