bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins
Authors: Hassan Reham , Myllys Maiju , Brackhagen Lisa , Hobloss Zaynab , González Daniela , Seddek Abdel-latif , Friebel Adrian , Hoehme Stefan , Marchan Rosemarie , Trauner Michael , Hengstler Jan G. , Ghallab Ahmed 
Published: September 2022

AbstractColchicine is an anti-inflammatory drug with a narrow therapeutic index. Its binding to tubulin prevents microtubule polymerization; however, little is known about how depolymerization of microtubules interferes with the phagocytosis function of Kupffer cells (KC). Here, we applied functional intravital imaging techniques to investigate the influence of microtubule disruption by colchicine on KC morphology, as well as its capacity to clear foreign particles and bacterial lipopolysaccharide (LPS) in anesthetized mice. Intravital imaging of KC in healthy mice showed the typical elongated morphology, localization at the luminal side of the sinusoidal endothelial cells, and moving cell protrusions. In contrast, at colchicine doses of 1 mg/kg and higher (intraperitoneal), KC appeared roundish with strongly reduced protrusions and motility. To study the functional consequences of these alterations, we analyzed the capacity of KC to phagocytose fluorescent nanospheres (100 nm-size) and LPS. After tail vein injection, the nanospheres formed aggregates of up to ~ 5 µm moving along the sinusoidal bloodstream. In controls, the nanosphere aggregates were rapidly captured by the Kupffer cell protrusions, followed by an internalization process that lasted up to 10 min. Similar capture events and internalization processes were observed after the administration of fluorescently labeled LPS. In contrast, capture and internalization of both nanospheres and LPS by KC were strongly reduced in colchicine-treated mice. Reduced phagocytosis of LPS was accompanied by aggravated production of inflammatory cytokines. Since 0.4 mg/kg colchicine in mice has been reported to be bio-equivalent to human therapeutic doses, the here-observed adverse effects on KC occurred at doses only slightly above those used clinically, and may be critical for patients with endotoxemia due to a leaky gut–blood barrier.
Visuospatial working memory and obstacle crossing in young and older people
Authors: Chu N. C. W. , Sturnieks D. L. , Lord S. R. , Menant J. C. 
Published: September 2022

AbstractObstacle crossing requires visuospatial working memory to guide the trailing leg trajectory when vision in unavailable. Visuospatial working memory, as assessed with neuropsychological tests, declines with age, however, this remains to be investigated functionally in obstacle crossing. There is also evidence that visuospatial encoding during a secondary task interferes with balance control during stepping and walking in older people. Here, we studied the interaction effects of age by delay (study 1) and age by secondary visuospatial task (study 2) conditions on obstacle clearance in a visuospatial working memory -guided obstacle crossing task. Healthy young adults aged 19 to 36 years (n = 20 in study 1 and n = 17 in study 2) and healthy older adults aged 66 to 83 years (n = 29 in study 1 and n = 21 in study 2) were instructed to step over an obstacle with their leading leg and straddle it for a delay period before completing the crossing with their trailing leg. In study 1, two obstacle height conditions (12 cm, 18 cm) and two delay durations (20 s, 60 s) were presented in random order. In study 2, participants were required to attend to either no secondary task (control), a visuospatial secondary (star movement) task, or a nonspatial secondary (arithmetic) task, while straddling the obstacle for a delay duration of 20 s, at obstacle heights of 12 cm and 18 cm, randomly presented. Trailing leg kinematics (mean and variability of maximum toe clearance over the obstacle) were determined via motion capture. There were no statistically significant age by delay or age by secondary task interactions. In study 1, toe clearance variability was significantly greater in young adults and increased with increasing delay duration in both groups. In study 2, compared with the control condition, toe clearance variability was significantly greater in the non-spatial secondary task condition but not in the visuospatial condition. Contrary to our hypotheses, these findings suggest that young and older adults alike can store an obstacle representation via visuospatial working memory for durations of at least 60 s and use this information to safely scale their trailing leg over an obstacle. However, the increase in trailing leg toe clearance variability with delay duration suggests that obstacle representation starts to deteriorate even within the first 20 s regardless of age. The finding that undertaking a concurrent arithmetic task impaired visuospatial working memory-guided obstacle clearance suggests a potential increased risk of tripping during obstacle crossing while dual-tasking in both young and older people.
Long Term Average Cost Control Problems Without Ergodicity
Authors: Ankirchner Stefan , Engelhardt Stefan 
Published: September 2022

AbstractWe consider a stochastic control problem with time-inhomogeneous linear dynamics and a long-term average quadratic cost functional. We provide sufficient conditions for the problem to be well-posed. We describe an explicit optimal control in terms of a bounded and non-negative solution of a Riccati equation on $$[0, \infty )$$

[
0
,
∞
)

, without an initial and terminal condition. We show that, in contrast to the time-homogeneous case, in the inhomogeneous case the optimally controlled state dynamics are not necessarily ergodic.
A McKean–Vlasov Game of Commodity Production, Consumption and Trading
Authors: Aïd René , Bonesini Ofelia , Callegaro Giorgia , Campi Luciano 
Published: September 2022

AbstractWe propose a model where a producer and a consumer can affect the price dynamics of some commodity controlling drift and volatility of, respectively, the production rate and the consumption rate. We assume that the producer has a short position in a forward contract on $$\lambda $$
λ
units of the underlying at a fixed price F, while the consumer has the corresponding long position. Moreover, both players are risk-averse with respect to their financial position and their risk aversions are modelled through an integrated-variance penalization. We study the impact of risk aversion on the interaction between the producer and the consumer as well as on the derivative price. In mathematical terms, we are dealing with a two-player linear-quadratic McKean–Vlasov stochastic differential game. Using methods based on the martingale optimality principle and BSDEs, we find a Nash equilibrium and characterize the corresponding strategies and payoffs in semi-explicit form. Furthermore, we compute the two indifference prices (one for the producer and one for the consumer) induced by that equilibrium and we determine the quantity $$\lambda $$
λ
such that the players agree on the price. Finally, we illustrate our results with some numerics. In particular, we focus on how the risk aversions and the volatility control costs of the players affect the derivative price.
Investigation of the effects of pulse width modulation on the laser sintering of LATP for all-solid-state batteries
Authors: Wehbe H. , Schmidt L. O. , Kandula M. W. , Dilger K. 
Published: September 2022

AbstractInorganic solid electrolytes are the most important component for realizing all-solid-state batteries with lithium metal anodes and enable safe battery cells with high energy densities. Their synthesis and processing are the subject of current research, especially the NASICON-type Li1+xAlxTi2-x(PO4)3 (LATP). Herein, the ability of sintering with electro-magnetic irradiation is investigated and correlated with different properties of prepared LATP pellets. First of all, an infrared camera records the temperature of the surface during the treatment. Second, the effect of the pulse fluence is investigated in terms of the topology and morphology of the pellets. Here, the arithmetic surface roughness Ra is the main parameter. Then, the depth of the radiation interaction in the pellet is measured. The focus of this paper is on the different pulse widths of the laser sources, and therefore, similar pulse and hatch overlap ensure equivalent areal energy input in both cases. As a summarized result, treatment with a shorter pulse width generates high peak pulse powers, resulting in higher temperatures, rougher surfaces and affecting deeper layers of the pellets compared to treatment with longer pulse width. On the contrary, excessive power leads to the ablation of the material up to destruction.
Vector-borne pathogens of zoonotic concern in dogs from a Quilombola community in northeastern Brazil
Authors: de Macedo Lucia Oliveira , Bezerra-Santos Marcos Antonio , Filho Carlos Roberto Cruz Ubirajara , da Silva Sales Kamila Gaudêncio , de Sousa-Paula Lucas C. , da Silva Lidiane Gomes , Dantas-Torres Filipe , do Nascimento Ramos Rafael Antonio , Otranto Domenico 
Published: September 2022

AbstractCanine vector-borne pathogens (CVBPs) comprise a group of disease agents mainly transmitted by ticks, fleas, mosquitoes and sand flies. In this study, we assessed the presence of CVBPs in an Afro-descendent community (Quilombola) of northeastern, Brazil. Dog blood samples (n = 201) were collected and analyzed by rapid test for the detection of antibodies against Leishmania spp., Anaplasma spp., Ehrlichia spp. and Borrelia burgdorferi sensu lato (s.l.), and antigens of Dirofilaria immitis. In addition, polymerase chain reactions were performed for Anaplasmataceae, Babesia spp., Hepatozoon spp., Rickettsia spp. and B. burgdorferi s.l. Overall, 66.7% of the dogs scored positive to at least one pathogen at serological and/or molecular methods. Antibodies against Ehrlichia spp. were the most frequently detected (57.2%; n = 115/201), followed by Anaplasma spp. (8.5%; n = 17/201), Leishmania spp. (8.5%; n = 17/201) and B. burgdorferi s.l. (0.5%; n = 1/201). For D. immitis, 11 out of 201 (5.5%) animals scored positive. At the molecular analysis, 10.4% (n = 21/201) of the samples scored positive for Babesia spp./Hepatozoon spp., followed by Anaplasmataceae (5.0%; n = 10/201) and Rickettsia spp. (3.0%; n = 6/201). All samples were negative for B. burgdorferi s.l. Our data demonstrated the presence of CVBPs in the studied population, with a high seropositivity for Ehrlichia spp. In addition, considering the detection of zoonotic pathogens in dogs and their relationship with people from Quilombola communities, effective control strategies are advocated for minimizing the risk of infection in this socially vulnerable human population and their pets.
From scattered data to actionable knowledge: flexible cyber security reporting in the military domain
Authors: Skopik Florian , Bonitz Arndt , Grantz Volker , Göhler Günter 
Published: September 2022

AbstractNumerous cyber situational awareness models have been proposed in recent years. Yet, one of the main challenges still remains mostly unsolved, which is what information sources contribute to the process for establishing cyber situational awareness and how is relevant information collected. While previous scientific works focused on situational awareness models and decision support based on common operating pictures, ingesting and maintaining a consistent data basis for the cyber domain has rarely been studied in detail. However, this is crucial when data distributed across different systems need to be collected, vetted, correlated, de-duplicated, enriched and finally stored as a basis for flexible cyber security reporting. In this paper, we design an approach and a data model that enable to ingest and store the essential information from disparate organizational units and act as a basis for the flexible creation of cyber security reports. We describe the application of this approach and model in a case study together with the Austrian Ministry of Defense (MoD), in which we surveyed existing data sources and transfer paths and rated the applicability of the CCOP data model and accompanying processes in course of a proof-of-concept implementation.
The two-step average tree value for graph and hypergraph games
Authors: Kang Liying , Khmelnitskaya Anna , Shan Erfang , Talman Dolf , Zhang Guang 
Published: September 2022

AbstractWe introduce the two-step average tree value for transferable utility games with restricted cooperation represented by undirected communication graphs or hypergraphs. The solution can be considered as an alternative for both the average tree solution for graph games and the average tree value for hypergraph games. Instead of averaging players’ marginal contributions corresponding to all admissible rooted spanning trees of the underlying (hyper)graph, which determines the average tree solution or value, we consider a two-step averaging procedure, in which first, for each player the average of players’ marginal contributions corresponding to all admissible rooted spanning trees that have this player as the root is calculated, and second, the average over all players of all the payoffs obtained in the first step is computed. In general these two approaches lead to different solution concepts. Contrary to the average tree value, the new solution satisfies component fairness and the total cooperation equal treatment property on the entire class of hypergraph games. Moreover, the two-step average tree value is axiomatized on the class of semi-cycle-free hypergraph games, which is more general than the class of cycle-free hypergraph games by allowing the underlying hypergraphs to contain certain cycles. The two-step average tree value is also core stable on the subclass of superadditive semi-cycle-free hypergraph games.
Extracellular vesicles derived from bone marrow mesenchymal stem cells loaded on magnetic nanoparticles delay the progression of diabetic osteoporosis via delivery of miR-150-5p
Authors: Xu Chen , Wang Zhaodong , Liu Yajun , Wei Bangguo , Liu Xiangyu , Duan Keyou , Zhou Pinghui , Xie Zhao , Wu Min , Guan Jianzhong 
Published: September 2022

AbstractExtracellular vesicles derived from bone marrow mesenchymal stem cells (BMSC-EVs) are emerged as carriers of therapeutic targets against bone disorders, yet its isolation and purification are limited with recent techniques. Magnetic nanoparticles (MNPs) can load EVs with a unique targeted drug delivery system. We constructed gold-coated magnetic nanoparticles (GMNPs) by decorating the surface of the Fe3O4@SiO2 core and a silica shell with poly(ethylene glycol) (PEG)-aldehyde (CHO) and examined the role of BMSC-EVs loaded on GMNPs in diabetic osteoporosis (DO). The osteoporosis-related differentially expressed miR-150-5p was singled out by microarray analysis. DO models were then established in Sprague–Dawley rats by streptozotocin injection, where poor expression of miR-150-5p was validated in the bone tissues. Next, GMNPE was prepared by combining GMNPs with anti-CD63, after which osteoblasts were co-cultured with the GMNPE-BMSC-EVs. The re-expression of miR-150-5p facilitated osteogenesis in osteoblasts. GMNPE could promote the enrichment of EVs in the bone tissues of DO rats. BMSC-EVs delivered miR-150-5p to osteoblasts, where miR-150-5p targeted MMP14 and consequently activated Wnt/β-catenin pathway. This effect contributed to the enhancement of osteoblast proliferation and maturation. Furthermore, GMNPE enhanced the EV-based delivery of miR-150-5p to regulate the MMP14/Wnt/β-catenin axis, resulting in promotion of osteogenesis. Overall, our findings suggest the potential of GMNP-BMSC-EVs to strengthen osteoblast proliferation and maturation in DO, showing promise as an appealing drug delivery strategy against DO.
Graphical abstract
1. GMNPs-BMSCs-EVs-miR-150-5p promotes the osteogenesis of DO rats.
2. miR-150-5p induces osteoblast proliferation and maturation by targeting MMP14.
3. Inhibition of MMP14 activates Wnt/β-catenin and increases osteogenesis.
4. miR-150-5p activates the Wnt/β-catenin pathway by downregulating MMP14.
Knowledge-building in an environment mediated by digital technology: A case study in higher education
Authors: Martín-Lucas Judith , García del Dujo Ángel 
Published: September 2022

AbstractThe advancement of technology in recent years seems to be prompting a re-ontologising of the world. Digital technology is transforming the educational spaces we inhabit, as well as our way of processing information. Although there are already numerous studies that have addressed this technological reality, only a handful have done so from a theoretical perspective. That is why we present research that seeks to reinforce the latest theoretical contributions for understanding how modern technology may be affecting the way in which knowledge is built. Based on the latest research in social constructivism, this is a qualitative study designed to contribute to the creation of a specific theoretical framework for an onlife world. An ill-structured task and a semi-structured interview were used to observe the use of the thinking skills that enable us to build knowledge and the relationship between them. The results show that the ways of building knowledge are changing, as digital technology fosters the use of higher-order thinking skills that, furthermore, operate in a chaotic, complex, and unpredictable manner. In conclusion, this study upholds the notion that the ways of building knowledge are changing, but we still need more empirical contributions to create a generally accepted theoretical construct for explaining how we build knowledge through digital technology.
Discrimination and Harassment Experiences of Autistic College Students and Their Neurotypical Peers: Risk and Protective Factors
Authors: Kim Sohyun An , Baczewski Lauren , Pizzano Maria , Kasari Connie , Sturm Alexandra 
Published: September 2022

AbstractThis study examines autistic and non-autistic college students’ experiences of discrimination and harassment and identifies protective and risk factors. A nationwide survey was used to match autistic students (N = 290) and non-autistic students (N = 290) on co-occurring diagnoses and demographic characteristics. Multiple regression and interaction analysis revealed that faculty support was protective against discrimination and harassment regardless of autism status. Habits of mind was particularly protective for autistic students against harassment. Any student who engaged in school-facilitated events was more likely to experience discrimination and harassment, but the risk was heightened for autistic students. Findings highlight the importance of faculty support in fostering positive interpersonal experiences on campus, and demonstrate the need to address deeper college campus issues with respect to neurodiversity.
Ex situ synthesis of MOF@PET/cotton textile fibers as potential antibacterial materials
Authors: Torres-Cortés Sergio Alejandro , Velasquez Mauricio , Pérez León Darío , Sierra César A. 
Published: September 2022

AbstractThere is considerable scientific literature on MOF-based antibacterial textiles, especially with in situ methodologies for their synthesis. On the contrary, the ex situ synthesis of MOFs on fabrics has been little explored. Although, the latter may have more significant advantages when the expectation is to scale up the process industrially. The present study describes the synthesis of ex situ obtained MOF-199 and MOF-UiO-66-NH2 onto carboxylated polyester/cotton (PETco) textile fibers and their preliminary-qualitative analysis as potential antibacterial textiles. For this, free synthesized MOFs were anchored on a previously carboxylated PETco fiber, using conditions that seek the formation of coordination bonds between the carboxyl groups of the fiber and the metal in the MOF. After soxhlet purification with water and methanol for more than 48 h, analysis by FTIR-ATR and XRD shows the superposition of signals typical of the fiber and the MOF, resembling what was previously reported for cotton-MOF systems. XPS showed 4.47% Cu, with Cu–O-C interactions for MOF-199@PETco, and 12.06% Zr, with Zr-O-C interactions for MOF UiO-66-NH2@PETco. Results corroborated by the SEM micrographs, which show the expected morphology for MOF-199, and homogeneously distributed MOF UiO-66-NH2 crystals when they are anchored to the fiber.
Better off without? Benefits and costs of resolving goal conflict through goal shelving and goal disengagement
Authors: Mayer Zita , Freund Alexandra M. 
Published: September 2022

AbstractPursuing multiple goals with limited time often leads to goal conflicts that can be resolved by prioritizing some goal pursuits over others. This research examines proximal outcomes of two approaches to goal prioritization: Goal shelving (temporarily withdrawing from a goal) and goal disengagement (permanently withdrawing from a goal). We conducted an experiment (N = 214) to compare motivational and emotional consequences of resolving goal conflict through goal shelving and disengagement. Results suggest that goal shelving and disengagement are similarly effective at reducing different facets of experienced goal conflict, but people regret shelving goals less than disengaging from them. Together, these findings provide first evidence that goal shelving may allow people to “have their cake and eat it too:” to reap the benefits of goal prioritization while minimizing its costs.
Subject pro-drop and past-tense auxiliary clitics in South-Western Ukrainian
Authors: Fellerer Jan 
Published: September 2022

AbstractSouth-Western Ukrainian dialects have retained the option of auxiliary clitics in the formation of the past tense. At the same time, they have past-tense forms without auxiliary clitics as in Northern Ukrainian dialects, and in Standard Ukrainian based on South-Eastern dialects. A sample corpus study suggests that South-Western Ukrainian also shows a higher frequency of subjectpro-drop than Standard Ukrainian. The South-Western Ukrainian pattern presents the precise mirror image of the same two features in South-Eastern ‘Borderland’ Polish. Here, the dialect adopted the option of past-tense forms without auxiliary clitics, next to those with them as in Standard Polish. At the same time, it shows a higher frequency of non-pro-drop than Standard Polish. I argue that these matching facts are the result of long- standing language contact that worked simultaneously in two directions: the increase in the use of an existing dialectal Ukrainian pattern under Polish influence, as well as the increase in the use of an existing dialectal Polish pattern under Ukrainian influence. As a result, both dialects show the same variation between past-tense forms with auxiliary clitics and without them, and they have mutually converging tendencies in subjectpro-drop – the Ukrainian dialect adapting towards Polishpro-drop, and the Polish dialect towards Ukrainian non-pro- drop. The bi-directionality of influence in the SWU dialectal area, thus, goes beyond other, unidirectional language-contact scenarios.