bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying predictors of varices grading in patients with cirrhosis using ensemble learning
Authors: Bayani Azadeh , Hosseini Azamossadat , Asadi Farkhondeh , Hatami Behzad , Kavousi Kaveh , Aria Mehrdad , Zali Mohammad Reza 
Published: July 2022

Abstract

Objectives
The present study was conducted to improve the performance of predictive methods by introducing the most important factors which have the highest effects on the prediction of esophageal varices (EV) grades among patients with cirrhosis.

Methods
In the present study, the ensemble learning methods, including Catboost and XGB classifier, were used to choose the most potent predictors of EV grades solely based on routine laboratory and clinical data, a dataset of 490 patients with cirrhosis gathered. To increase the validity of the results, a five-fold cross-validation method was applied. The model was conducted using python language, Anaconda open-source platform. TRIPOD checklist for prediction model development was completed.

Results
The Catboost model predicted all the targets correctly with 100% precision. However, the XGB classifier had the best performance for predicting grades 0 and 1, and totally the accuracy was 91.02%. The most significant variables, according to the best performing model, which was CatBoost, were child score, white blood cell (WBC), vitalism K (K), and international normalized ratio (INR).

Conclusions
Using machine learning models, especially ensemble learning models, can remarkably increase the prediction performance. The models allow practitioners to predict EV risk at any clinical visit and decrease unneeded esophagogastroduodenoscopy (EGD) and consequently reduce morbidity, mortality, and cost of the long-term follow-ups for patients with cirrhosis.
Польская политика «мягкой силы» в отношении Республики Беларусь: концепции и практика
Authors: Li Chongyang 
Published: July 2022

Аннотация
В статье рассматриваются основные концепции и направления реализации Польшей политики мягкой силы в отношении Республики Беларусь. Анализируются исторические предпосылки формирования польско-белорусских отношений на современном этапе и политика Варшавы в отношении так называемых «Восточных Кресов» в межвоенный период XX столетия. Проанализированы и выделены основные направления деятельности Польши в отношении РБ в контексте сложного отношения польских властей к политической системе президента Лукашенко, а также вхождения Польши в состав ЕС. Детально рассматриваются усилия Варшавы по поддержке независимых неправительственных и некоммерческих организаций в Беларуси, содействие продвижению в республике влияния католической церкви, а также работы с белорусской диаспорой и политиками-эмигрантами из РБ в самой Польше.
Development of Relations Between China and Czechoslovakia and Its Successor States, Czechia and Slovakia
Authors: Jiang Li 
Published: July 2022

Abstract
Over the past 72 years since China established diplomatic relations with Czechoslovakia in 1949, bilateral relations between China and Czechoslovakia and its successor states, Czechia and Slovakia, have seen ups and downs, thanks to evolving domestic and international situations. While China-Czechoslovakia relations showed distinguishing features in different periods, relationships between China and Czechia, and between China and Slovakia have patterns of their own. To be more specific, China-Czechia relations have experienced more twists and turns influenced by factors like ideology, partisan interests, and history which led Czech political elites to adopt different policies towards China.
Spiritual leaf shape compact MIMO patch antenna for 5G lower sub-6 GHz applications
Authors: Jyothi Sree Gorre Naga , Nelaturi Suman 
Published: July 2022

AbstractFor the 5G applications of future sub-6 GHz a novel planar very low compact MIMO antenna is designed with improved isolation and impedance matching with T-shaped ground plane and mode analysis is presented here. A very low compact substrate with an area of 48 mm × 24 mm spiritual leaf shape radiating patches are situated in the same direction and maintained a separation distance of 2 mm. To improve the isolation and improved bandwidth, a remodeled structure of T-shaped grounded stub is placed among the pair of radiating antenna elements. The spiritual shaped antenna maintain a −10 dB required operating band of 2.43–3.01 GHz (580 MHz) and 3.19–3.84 GHz (650 MHz) with an isolation more than 20 dB maintained between antenna elements. The spiritual leaf shape antenna offers a radiation efficiency of 94.4 & 86.99% and its peak gain about 7.2 & 6.3 dBi. The simulated isolation is greater than 30 dB thought the dual-band with a maximum isolation of 54 dB. For this MIMO design diversity gain is around 10 dBi, channel capacity loss is less than 0.2 bits/s/Hz, group delay <1 ns and envelope correlation coefficient (ECC) which is lower than 0.0478.
Hypoxia-inducible factor-1α and ischemia-modified albumin levels in intensive care COVID-19 Patients
Authors: Yucel Kamile , Fuat Gurbuz Ali 
Published: July 2022

Abstract

Objectives
In this study, it was aimed to evaluate the hypoxia-inducible factor-1α (HIF-1α) and ischemia-modified albumin (IMA) levels of patients diagnosed with COVID-19 in the intensive care unit (ICU) and healthy controls. To our knowledge, this is the first study investigate HIF-1α and IMA levels in COVID-19 patients in ICUs and comparing them with a healthy control group. For this reason, our study is original and will contribute to the literature.

Methods
A total of 70 intensive care patients diagnosed with COVID-19, and 72 healthy controls were included in the study.

Results
When we compared the patient and healthy control group; there were no statistically significant differences between the groups in terms of age and gender (p>0.05). No exitus was observed in the patient group. We found weak correlation between HIF-1α and IMA (r: 0.320). However, there were statistically significant differences in HIF-1α and IMA levels in the patient group. The receiver operating characteristic (ROC) curve demonstrated an area under curve (AUC) value of 0.651 for HIF-1α and 0.937 for IMA.

Conclusions
The HIF-1α and IMA levels were significantly higher among COVID-19 patients in ICU compared with healthy controls. HIF-1α and IMA levels can be used as reliable markers for the prognosis of COVID-19.
Application of sustainable power and laser washing device in garment design
Authors: Luan Xiaoli 
Published: July 2022

Abstract
With social progress, economic development, the rapid improvement of science, technology and productivity, and the profound change of social productivity, there has been a serious energy and environmental crisis all over the world. By using the candle burning effect of laser, the laser cleaning device can directly absorb the laser energy, vaporize and decompose the pollutants on the surface of clothing materials, so as to achieve the purpose of cleaning. Energy is an important material basis for human survival and development. Stable, reliable and safe energy supply system and efficient, economic and clean energy utilization are indispensable. The prediction of the development trend of solar power generation technology shows that the trend of optical fiber power generation is clear. The combination of sustainable power and laser water washing device is applied to the garment cleaning process. It analyzes that the garment materials are affected by the laser cleaning speed and laser cleaning power in the cleaning process, and adjusts the appropriate parameters to achieve effective cleaning. The application of sustainable power generated by photovoltaic power generation to the actual process of clothing can not only reduce the consumption of natural resources, environmental pollution and other problems, but also be applied to clothing and other manufacturing industries without restrictions. In the era of sustainable development, energy plays an important role in the coordinated development of economy, society and environment. When the carbon fiber surface is cleaned by laser, the relationship between cleaning spacing, cleaning speed, cleaning area and cleaning time is conducive to formulate a reasonable cleaning scheme. According to the experimental research, when the power P = 100 W, the carbon fiber surface is cleaned of particulate matter, and the laser-cleaned surface is in better condition than when it is treated at high temperatures.
Interculturality and Islam in Indonesia’s high-school EFL classrooms
Authors: Munandar Muhammad Iwan 
Published: July 2022

AbstractThis paper describes English as a foreign language (EFL) teachers’ pedagogic beliefs and practices regarding culture and interculturality and the extent to which Islamic outlook informed their instruction. Five Indonesian high-school EFL teachers participated in this study. Data were collected over a 12-week period through classroom observations, narrative frames, and stimulated-recall and in-depth interviews. Findings were analysed using a qualitative framework. Evidence indicates that participating teachers often drew on home knowledge and religious significance to make sense of ideas expressed in English. Despite realising the global prominence of English, there were hints that the teachers lumped members of the target culture together. Ambiguities surrounding the teachers’ instruction reveal paradoxes of educational exigencies and attitudinal resistance to ostensibly Western culture. This study calls for EFL pedagogies being more responsive to local linguistic repertoire and religio-cultural factors, highlighting the need to liberate the English classes from rigid ties to particular cultures.
Obstetric hemorrhage: effective methods for addressing the menace in Sub-Saharan Africa
Authors: Abdullahi Hauwa Musa , Aliyu Labaran Dayyabu , Yusuf Murtala , Miko Mustapha Abdullahi 
Published: July 2022

Abstract
Obstetric hemorrhage is a serious emergency. It can occur late in pregnancy and in the immediate postpartum period. Postpartum hemorrhage is the major contributor of maternal deaths worldwide. The incidence of PPH-associated death across the African continent is at least three times higher than in other regions of the world. About 17% of PPH result in severe morbidity, including significant organ impairment. Maternal death and disability have long-lasting negative consequences for children, families, and communities. There are considerable variations across regions with for instance PPH accounting for about 8.0% of maternal deaths in developed countries compared to 19.7% in the developing countries. This disparity suggests that the majority of lives lost from PPH are preventable. Instituting primary preventive measures, prenatal care, comprehensive antenatal care, understanding the concept of birth preparedness and complication readiness, skilled birth attendant at delivery, avoiding delays, availability of comprehensive emergency obstetric care (CEmOC), good political will and disseminating the information on maternal mortality from PPH to the community are among key elements necessary to address the menace of PPH in developing countries. The aim of this review is to highlight the contributions of obstetric hemorrhage as a significant cause of maternal morbidity and mortality and suggest measures of prevention.
Mesolithic and Chalcolithic Mandibular Morphology: Using Geometric Morphometrics to Reconstruct Incomplete Specimens and Analyse Morphology
Authors: Godinho Ricardo Miguel , Umbelino Cláudia , Gonçalves Célia 
Published: July 2022

Abstract
Human skeletal remains are routinely used to examine cultural and biological aspects of past populations. Yet, archaeological specimens are frequently fragmented/incomplete and so excluded from analyses. This leads to decreased sample sizes and to potentially biased results. Digital methods are now frequently used to restore/estimate the original morphology of fragmented/incomplete specimens. Such methods include 3D digitisation and Geometric Morphometrics (GM). The latter is also a solidly established method now to examine morphology. In this study, we use GM-based methods to estimate the original morphology of incomplete Mesolithic and Chalcolithic mandibles originating from present Portugal and perform ensuing morphological analyses. Because mandibular morphology is known to relate to population history and diet, we hypothesised the two samples would differ. Thirty-seven specimens (12 complete and 25 incomplete) were CT-scanned and landmarked. Originally complete specimens were used as reference to estimate the location of absent anatomical landmarks in incomplete specimens. As predicted, our results show shape differences between the two samples which are likely due to the compounded effect of contrasting population histories and diets.
Development of Eight Wireless Automated Cages System with Two Lickometers Each for Rodents
Authors: Cardoso Melo Mariana , Alves Paulo Eduardo , Nogueira Cecyn Marianna , Eduardo Paula Mendonça C. , Abrahao Karina P. 
Published: July 2022

AbstractDrinking behavior has been used in fundamental research to study metabolism, motivation, decision-making and different aspects of health problems, such as anhedonia and alcohol use disorders. In the majority of studies, liquid intake is measured by weighing the bottles before and after the experiment. This method does not tell much about the drinking microstructure, e.g., licking bouts and periods of preference for each liquid, which could be valuable to understand drinking behavior. To improve data acquisition of drinking microstructure, companies have developed lickometer devices that acquire timestamps when animals approach or drink from a specific sipper. Nevertheless, commercially available devices have elevated costs. Here, we present a low-cost alternative for a lickometer system that allows wireless data acquisition of licks from eight cages with two sippers each. We ran a three-phase validation protocol to ensure (1) proper choice of the sensor to detect licks; (2) adaptation of the device to a wireless transmission and realisticin silicotests; and (3)in vivovalidation to test the correlation between the amount of licks measured by the lickometer and the bottle weight. The capacitive sensor presented appropriate recall and precision for our device. After adaptation to wireless transmission, thein silicovalidation demonstrated low reading and transmission errors even when tested in extreme simultaneous licking conditions. Finally, we observed a positive correlation between water or ethanol consumption and lick count, showing that the lickometers can be used forin vivostudies interested in rodent drinking microstructure.
Mechanosensor Piezo1 mediates bimodal patterns of intracellular calcium and FAK signaling
Authors: Pan Yijia , Shi Linda Zhixia , Yoon Chi Woo , Preece Daryl , Gomez‐Godinez Veronica , Lu Shaoying , Carmona Christopher , Woo Seung‐Hyun , Chien Shu , Berns Michael W , Liu Longwei , Wang Yingxiao 
Published: July 2022

AbstractPiezo1 belongs to mechano‐activatable cation channels serving as biological force sensors. However, the molecular events downstream of Piezo1 activation remain unclear. In this study, we used biosensors based on fluorescence resonance energy transfer (FRET) to investigate the dynamic modes of Piezo1‐mediated signaling and revealed a bimodal pattern of Piezo1‐induced intracellular calcium signaling. Laser‐induced shockwaves (LIS) and its associated shear stress can mechanically activate Piezo1 to induce transient intracellular calcium (Ca[i]) elevation, accompanied by an increase in FAK activity. Interestingly, multiple pulses of shockwave stimulation caused a more sustained calcium increase and a decrease in FAK activity. Similarly, tuning the degree of Piezo1 activation by titrating either the dosage of Piezo1 ligand Yoda1 or the expression level of Piezo1 produced a similar bimodal pattern of FAK responses. Further investigations revealed that SHP2 serves as an intermediate regulator mediating this bimodal pattern in Piezo1 sensing and signaling. These results suggest that the degrees of Piezo1 activation induced by both mechanical LIS and chemical ligand stimulation may determine downstream signaling characteristics.
Benefits of rescreening newborns of mothers affected by autoimmune hypothyroidism
Authors: Cavarzere Paolo , Palma Laura , Nicolussi Principe Lara , Vincenzi Monica , Lauriola Silvana , Gaudino Rossella , Murri Virginia , Lubrano Luigi , Rossi Giuliana , Sallemi Alessia , Fattori Ermanna , Camilot Marta , Antoniazzi Franco 
Published: July 2022

Introduction
Infants of mothers with autoimmune hypothyroidism (AH) are at risk of developing late-onset hypothyroidism, often escaping at newborn screening. This condition might be caused both by the action of maternal antibodies and/or by maternal treatment.

Objectives
The aim of this study is to evaluate the prevalence of AH in the mothers of children born in Veneto region, Italy, and to define what is the most appropriate management for these newborns.

Methods
Newborns of six different hospitals with a mother suffering from AH and with negative neonatal screening for congenital hypothyroidism (CH) were included in the study. Between 15 and 20 days of life, we collected a serum sample for the evaluation of thyroid function (thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3)) and anti-thyroid antibodies. On the same occasion, a capillary blood sampling was performed for a second screening test.

Results
Maternal AH has a prevalence of 3.5%. A total of 291 newborns were enrolled from November 2019 to May 2021. Whereas the 11.4% of infants had a slight elevated serum TSH (>6 mU/L) and required a follow-up, only 2 children presented an elevated TSH level at the second screening test. One of these, with the gland in situ, showed persistently elevated serum TSH levels and required treatment with levothyroxine.

Conclusions
Maternal AH rarely caused neonatal thyroid dysfunction. We suggest to reassess newborns from mothers with AH 15 days after birth by means of a second neonatal screening test. This procedure avoids false negatives due to maternal thyroid status, is less invasive and cheaper than the serum TSH evaluation, and prevents a long follow-up.
Redox experimental medicine and liver regeneration
Authors: Bellanti Francesco , Vendemiale Gianluigi , Serviddio Gaetano 
Published: July 2022

The liver is characterized by unique regenerative properties to restore its mass and function after a partial loss. Hepatic regeneration arises after resection or following acute and chronic injuries. Resection and acute liver damage normally induce a regenerative process characterized by phenotypic fidelity, in which each cell type promotes its own replication and replacement. This process fails in chronic liver damage, where trans-differentiation of parenchymal cells or activation of facultative progenitors occurs. Both liver resection and acute/chronic damages alter redox homeostasis, as a consequence of blood flow changes, hypoxia, metabolism modification, and activation of inflammatory response. Even though formerly described as ‘oxidative stress’, altered redox homeostasis leads to the fine regulation of several pathways involved in liver regeneration, including the proliferation of parenchymal cells, trans-differentiation, and activation of facultative progenitors.
Several redox-dependent transcription factors and pathways implicated in the regenerative process of the liver were described, but pre-clinical experiments using different antioxidants were not fully conclusive. Even though accurate study designs to define appropriate dosages, treatment duration, and routes of administration are required, modulation of redox-dependent molecular pathways to enhance liver regeneration is even more intriguing. Preliminary studies focused on the identification of these targets will pave the way for viable therapies to be tested in clinical trials.
Covid-19 Vaccines and its Adverse Events Following Immunization( AEFI)
Authors: Bralianti Putri Dwi , Akbar Femmy Nurul 
Published: July 2022

Background: The Indonesian government has begub to administer vaccines en mass and is planned in stages as an effort to prevent and control Covid-19 by immunity. To reduce the negative impact of immunization on individual health and the implementation of vaccination itself, it is best to know Covid-19 vaccines in Indonesia and their AEFI.Objective: The purpose of this article is to discuss Covid-19 vaccines in Indonesia and their AEFIMethod: Systematic review of studies about Covid-19 vaccines that have been and will be used in Indonesia along with an overview of AEFI.Results: There are five Covid-19 vaccines manufacturer that has been and will be used in Indonesia. The types of antigens used in the Covid-19 vaccine include a whole virus, protein subunits, and nucleic acid. Conclusion: Covid-19 vaccines are relatively safe and can rarely cause AEFI.
The Relationship Between Adequacy of Hemodialysis and Anemia in Chronic Kidney Diseases (Ckd) Patients Undergoing Hemodialysis in Dialysis Unit, Fatmawati Hospital
Authors: Ginting Leo , Aziz Abdul , Wulandari Wulandari , Lasono Dwi Budi 
Published: July 2022

Background: Anemia is a common problem that often occurs in patients with CKD undergoing hemodialysis. 56.5% of hemodialysis patients were still have anemia, while on the other hand, the achievement of hemodialysis. adequacy only reached 52.7%. Disparity that data is the basis for this research. The aim of this study is to analysis the relationship between the achievement of hemodialysis adequacy with the incidence of anemia in patients with CKD undergoing hemodialysis.Methods: This study uses a descriptive correlation with a cross sectional approach to the analysis of the independent variable (HD Adequacy) and the dependent variable (Anemia). The relationship between these variables was tested using the Chi Square test.Result: The study was conducted on 134 hemodialysis patients aged 13-86 years, the most common vascular access was AV fistula (68.7%), and women were the most respondents (55.2%). The Kt / V value in this study was 1.67 (1.03-2.75) and an adequate one was 54.5%. Adequate URR reached 80.6% with a mean of 75.13 ± 6.38. The incidence of anemia reached 53.7% with the Hb value at 8.93 ± 2.82 mg / dl. The results of the Chi Square test showed that HD adequacy (Kt / V and URR) with the incidence of anemia had P values of 0.670 and 0.217.Conclusion: There is no significant relationship between HD adequacy and the incidence of anemia
Comparación de los impactos ambientales ocasionados por la técnica de incineración y rellenos sanitarios para la gestión de residuos sólidos
Authors: Chavarría Acuña Osvaldo Antonio 
Published: July 2022

En el presente documento se plantea hacer una comparación entre las técnicas de relleno sanitario e incineración, para lo cual, se ha seleccionado estratégicamente un sitio en donde cuyas actividades inciden de manera significativa sobre los componentes ambientales, por lo que el proyecto representa un caso supuesto para cuantificar los impactos bajo ciertas condiciones, y evaluado mediante la matriz de Leopold, la cual permite medir la interacción de actividades propias de un proyecto sobre los factores ambientales del proyecto.
Ambas técnicas no resultan ambientalmente viables para el sitio propuesto, siendo el relleno sanitario más impactante. Se requieren realizar estudios técnicos que permitan depurar la magnitud de los impactos, así como proponer medidas ambientales durante su ejecución. Se recomienda seleccionar un sitio con características poco sensibles desde el punto de vista ambiental y social, para favorecer la viabilidad del proyecto.