bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study the Pharmacognostic Profile, Antiradical and Hepatoprotective
Potential of Carissa carandas Linn. Fruit Extract
Authors: Singh Sonia , Agarwal Nitin 
Published: March 2022

Aims:
Carissa carandas Linn. is a thorny shrub (Family: Apocynaceae), commonly
called Karonda. The shrub can be grown in tropical and subtropical climate regions.

Methods and Material:
The objective of the experimental work was to analyze the efficacy of
fruit extract of C. carandas Linn. with respect to the hepatoprotective property using supportive
evidence of in vitro and in vivo antiradical activity. The antioxidant activity of ethanolic fruit extract
was determined by 2, 2-diphenyl-1-picrylhydrazyl (DPPH), hydrogen peroxide and nitric
oxide free radical scavenging assay, using Ascorbic acid as a standard drug. Oral administration of
C. carandas Linn. ethanolic fruit extract (200 and 400 mg/kg) revealed a considerable marked
protection property against acute hepatotoxicity induced by the carbon tetrachloride, moreover,
that has been evaluated in terms of biochemical parameters.

Results:
Administration of carbon tetrachloride (CCl4) induce amplified levels of serum biomarker
enzymes including alanine aminotransferase (ALT), aspartate transaminase (AST) and alkaline
phosphatase (ALP) in the blood serum with attenuated in-vivo antioxidant enzymes levels such as
superoxide dismutase (SOD), reduced glutathione (GSH) and catalase in hepatic tissues. The administration
of fruit extract would reduce the CCl4- induced hepatic toxicity; these effects may be
due to the presence of phytochemicals including carbohydrates, tannins, phenolic components and
flavonoids. However, HPLC and TLC studies would ensure the presence of gallic and quercetin in
the ethanolic fruit extract of the plant.

Conclusions:
The ethanolic fruit extract of C. carandas Linn. exhibits significant hepatoprotective
activity which could be partly imputed to its both in-vitro as well as in-vivo antioxidant property,
together with effective total phenolic and total flavonoid content and thus concedes for further
findings.
Population and Habitat Suitability Index Model of Bali Starling (Leucopsar rothschildi) in West Bali National Park
Authors: Pramatana Fadlan , Hernowo Jarwadi Budi , Prasetyo Lilik Budi 
Published: March 2022

Bali starling (Leucopsar rothschildi) is categorized as an endangered species based on the International Union for Conservation of Nature and Natural Resources (IUCN) red list. Thus, preventing this species from extinction becomes very crucial. One of the most important activities for this purpose is a soft release method to avoid birds’ mortality, which has been done in West Bali National Park (WBNP). However, this method creates the dependency of birds to the artificial treatment and may affect the distribution of Bali starling. Therefore, this study aimed to analyze the population and habitat and create a habitat suitability index model for Bali starling in WBNP. Data were obtained by surveying the Bali starling population, including the number of individuals, distribution, age structure, sex ratio, natality, and mortality. Vegetation analysis was also conducted to determine habitat conditions. Finally, map interpretation data was used to develop a suitable habitat model for Bali starling in WBNP. The results showed that 63 Bali starling were found near the resort office, bird release sites, and binding bird cages. It indicated that the habitat of Bali starling has shifted from the soft release site. The habitat suitability index model of Bali starling in WBNP was Y = 17.145 + 6.640PC1 - 4.055PC2, showing the selected variables only give a moderate determination coefficient (R2 = 40.9%). The artificial treatment created by the WBNP authority seems to be another great factor influencing the existence and distribution of Bali starling in WBNP. It was also indicated that Bali starling could breed in the WBNP, but it tends to have a shifting habitat in the wild.
Keywords: Bali starling, Geographic information system, Habitat suitability, Population
Un-Silencing the Past: A Juxtaposition of Personal and Political in Elif Shafak’s Novel, The Bastard of Istanbul
Authors: Islam Tajamul 
Published: March 2022

This paper explores the thematic aspect of bastard and the alternative spaces present in the novel to show how Armenian genocide is addressed and unsilenced from the censorship of the State. The juxtaposition of the Armenian issue with the tribulations of ‘Kazanci’ family is argued as a metaphorical and personalised account of Armenian genocide. Such an engagement with the past has been made possible by bringing political and personal together in the form of a family in Istanbul and a family in America; one belonging to a Muslim majority and the other belonging to an Armenian religious minority.
Training Culturally Congruent Health Coaches to be Socially-Embedded Support on Physical Activity among Older Asian Americans: Phase One Report
Authors: Caboral-Stevens Meriam , Wu Tsu-Yin 
Published: March 2022

There is a reported heterogeneity in burden with cardiovascular disease (CVD) among Asian Americans subgroups. Physical inactivity is an identified key risk factor for CVD, across age and race/ethnic backgrounds. The latest data showed that 42% of Asian Americans are physically inactive. Health coaching is a rapidly emerging primary or supplemental intervention to address issues related to preventable chronic illness, including physical inactivity. Hence, the purpose of this paper is to describe Phase One of this project - training of culturally congruent Health Coaches as socially embedded social support to promote physical activity to their older Asian communities. A 3-day training curriculum was developed based on the four pillars of Health Coaching and the Transtheoretical Model of Change. Fifteen Asian Americans Health Coaches were trained using this curriculum. Fifteen health coaches completed the 3-day training. Phase Two of this project is ongoing and results may provide information on the long-term effects of health coaching among older Asian Americans.
Effects of Demographic Characteristics and Consumer Behavior in the selection of Retail Pharmacies and Over-the-Counter Medicine
Authors: Kevrekidis D.P. , Mináriková D. , Markos A. 
Published: March 2022

Abstract

Aim
The study aimed to provide new insights into consumer behaviour by identifying the key demographic factors that influence the choice of pharmacy and over-the-counter (OTC) medicine.

Materials and Methods
A cross-sectional study was conducted in an urban area (Thessaloniki, Greece), surveying a convenience sample of 314 consumers with a structured questionnaire. Data analysis was conducted using the chi-square test, one-way analyses of variance (ANOVAs) and Spearman's rho correlation coefficient.

Results
Respondents with a lower educational level and retired consumers tended to make their purchases in a single pharmacy (p < 0.001). Older participants were more likely to consider the pharmacy staff and additional services to be important factors (p < 0.01). Students were the only group to prefer a formal relationship with the pharmacy staff (p < 0.001). Participants with a lower educational level tended to know exactly what they would buy (p < 0.05), whereas women made more unscheduled purchases of OTCs (p < 0.05). Respondents with a higher income assigned more importance to the product's country of origin (p < 0.05) and manufacturing company (p < 0.01) and less importance to the pharmacist's opinion than those of a lower income (p < 0.05).

Conclusions
The educational level, occupation and age of consumers have a marked effect in their selection of pharmacy, and along with gender and personal income, in their choice of OTC medicine. Our findings yield implications for the management of community pharmacies.
Russian Spatial Development Strategy: blind spots in regional specialisations
Authors: Kozyr N. S. 
Published: March 2022

The state “Russian Spatial Development Strategy for the period up to 2025” has not only aroused interest in the scientific community, but has also been the object of criticism on the issues of consistency of the prospective economic specialisations of the constituent entities of the Russian Federation to spatial development objectives. To identify gaps in the content of this strategy, the article compares the economic specialisations of the constituent entities of the Russian Federation with the types of activities described in the “Russian Classification of Economic Activities (OKVED-2) 2021”. The data obtained were compared with the gross value added statistics of the Russian industry structure. The representation of high-tech and knowledge-intensive industries in promising regional economic specialisations was analysed. The results of the study extend the list of criticisms from the Russian scientific community regarding the indicated document. However, a review of foreign studies has shown that the difficulties of strategy development are also inherent in countries with strong planning traditions. An unambiguous conclusion is the need to create a new structure and content document, taking into account the trends in the world and society technological development.
Pelos silêncios das Tisanas, de Ana Hatherly
Authors: Araujo Rodrigo da Costa 
Published: March 2022

A poesia e a obra de arte, nos dinamismos que lhes são inerentes, instituem um espírito de crítica e um afã interpretativo, em busca de um redimensionamento de sua criatividade. O objetivo dessa crítica assume um questionamento da própria realidade que a obra/poesia procura representar e influenciar. Assim também são os traços delicados do livro de poesias Tisanas, da artista plástica, poeta, romancista, ensaísta e tradutora portuguesa, Ana Hatherly (1929-2015).
İŞ-AİLE ZENGİNLEŞMESİNİN YAŞAM TATMİNİ, KARİYER TATMİNİ VE İŞ YÜKÜ FAZLALIĞI ALGISINA ETKİSİ: ISPARTA İLİ BANKA ÇALIŞANLARI ÜZERİNE BİR ARAŞTIRMA
Authors: OKUDUR SABUNCU Betül , ATİLLA Gaye 
Published: March 2022

Bu çalışma iş-aile zenginleşmesinin, yaşam tatmini, kariyer tatmini ve iş yükü fazlalığı algısına etkisini ölçmeyi hedeflemektedir. Araştırma Isparta il merkezindeki banka çalışanlarının tamamını kapsamaktadır. Araştırmada anket yöntemi kullanılmış, veriler kolayda örnekleme yoluyla elde edilmiştir. Çalışmaya 200 banka çalışanı katılmıştır. Araştırmada Carlson vd. (2006) tarafından geliştirilen iş-aile zenginleşmesi ölçeği’nin Kaçmar vd. (2014) tarafından oluşturulan kısa formu kullanılmıştır. Yaşam tatminini ölçmek amacıyla Diener vd. (1985), kariyer tatmini için Greenhaus vd. (1990) ve iş yükü fazlalığı için Imosili (1985) tarafından geliştirilen iş yükü fazlalığı ölçeği kullanılmıştır. Bununla birlikte cinsiyet, medeni durum, çocuk sayısı, kurum türü gibi bazı demografik sorulara yer verilmiştir.
Araştırmada regresyon analizi, korelasyon analizi ve bağımlı değişkenin demografik özelliklere göre farklılık gösterip göstermediğini ölçmek üzere t testi uygulanmıştır. Toplanan verilerin analizinde SPSS 22.0 programından yararlanılmıştır. Araştırma sonucunda, iş-aile zenginleşmesinin; kariyer ve yaşam tatmini ile pozitif, iş yükü fazlalığı ile negatif yönde ilişkili olduğu görülmüştür. Regresyon analizine göre, işten aileye zenginleşmenin kariyer tatmini, yaşam tatmini ve iş yükü fazlalığı algısını etkilediği, aileden işe zenginleşmenin de kariyer tatminini, yaşam tatminini ve iş yükü fazlalığı algısını etkilediği görülmüştür. Ayrıca iş-aile zenginleşmesinin, banka personelinin eşinin çalışma durumuna, çalıştığı kurumun türüne, yapısına ve çalıştığı birime göre farklılık gösterdiği sonucuna ulaşılmıştır.
KIRGIZİSTAN BURANA'DAKİ (BALASAGUN) KÜLTÜR VARLIKLARININ DURUMU
Authors: AYKAÇ Razan 
Published: March 2022

Özet: Burana (Balasagun), V- XI yüzyıllar arasında İpekyolu’nun önemli şehirlerinden biri olmuştur. Şehir X. yüzyılda, Karahanlıların hâkimiyetine geçtikten sonra, Orta Çağ Türk-İslam kent dokusuna uygun olarak yeniden inşa edilmiştir. Buna göre; etrafı surla tahkim edilmiş dış kale, şehristanda Cuma Camisi, pazar yerleri, mahalleleri ve mahalle camileri, medreseleri, türbeleri, hamamları, dükkânları, sivil konutları ile iç kaleden oluşan bir kent olduğu anlaşılmaktadır. Karahanlı dönemi Orta Çağ Türk-İslam şehir dokusunu yansıtan ilk örnek olması açısından Burana (Balasagun) şehri oldukça önemlidir.
Şehrin Cuma Camisi’nin minaresi olan Burana Minaresi, mahalle camisi olan Burana Cami ayrıca I, II ve III no.lu türbelerde XIX ve XX. yüzyılda sondaj çalışmaları yapılmıştır. Kısmı tamir de geçiren bu yapılar plan, süsleme ve İslami dönem kent dokusunu yansıtması açısından öncü yapılardır.
1976 yılında Kırgız Hükümeti tarafından Burana (Balasagun) şehri ören yeri olarak devlet korumasına alınmış, burası Açık Hava Müzesi özelliği kazanmıştır. Başta şehirdeki eserler olmak üzere çevredeki müzelik eserler burada sergilenmektedir. Eserler arasında; Burana Minaresi (Cuma Camisi’nin minaresi), Burana (Mahalle) Camisi ayrıca I, II ve III no.lu türbeler, petroglifler, balballar ile İslami dönem mezar taşları yer almaktadır.
Bu makalede ilk Türk-İslam devleti olan Karahanlıların başkenti Burana (Balasagun) şehri ve içindeki eserler kent dokusu bağlamında ele alınmıştır.
A study on environmental violations for Brazilian municipalities: A limited information maximum likelihood approach to a spatial dynamic panel data
Authors: Uhr Julia Galle , Chagas André Squarize , Uhr Daniel De Abreu Pereira , Peres Renan Porn 
Published: March 2022

This paper presents new evidence for environmental offenses in Brazil. IBAMA’s strategy to deter violations is based on large operations and on decapitalizing offenders to signal its will to monitor and enforce the law, addressing the following questions: Do the sanctions applied by IBAMA, especially sanction charges, deter actual and potential offenders? Are there any spatial or temporal patterns affecting violations? This work contributes to the existing research by providing evidence for Brazil and by incorporating spatial controls in a dynamic panel approach to explain infractions against the environment. The data comes from an extensive database on offenses against flora and applied fines for Brazilian municipalities between 1998-2015. A new Spatial Dynamic Limited Information Maximum Likelihood (SDLIML) approach is proposed to address the additional endogeneity between fines and values of penalties. Results show that there is a pedagogic deterrent effect associated with applied fine values. Sanction charges are important to discourage new offenses.
Himalayan Giant Honey Bee, Cliff Honey Bee (suggested common names) Apis laboriosa Smith (Insecta: Hymenoptera: Apidae)
Authors: Gregory Michelle , Jack Cameron 
Published: March 2022

The Featured Creatures collection provides in-depth profiles of insects, nematodes, arachnids and other organisms relevant to Florida. These profiles are intended for the use of interested laypersons with some knowledge of biology as well as academic audiences.
Although the Himalayan giant honey bee Apis laboriosa Smith is the largest honey bee species in the world, it is also one of the least studied. It has a distribution mostly concentrated in the Hindu Kush Himalayan region of southern Asia.
Energy feed additive in the diets of pregnant dry cows
Authors: Budnikova O. N. , Gamko L. N. 
Published: March 2022

Relevance. In this article, the effect of an energy feed additive on obtaining healthy offspring and subsequent high milk productivity is established. As a result of feeding different doses of an energy feed additive with the same composition of the feed mixture to dry cows 14 days before calving, calves with an average live weight at birth were obtained in the second experimental group: heifers — 43 kg, bulls — 40.3 kg, in the third experimental group heifers at birth had a live weight of 36.6 kg, bulls — 43.6 kg. After 20 days of milk drinking, the heifers obtained from cows of the second experimental group, who were fed 190 g of energy feed additive, retained growth energy and exceeded the bulls by 1.3 kg, in the third experimental group, the bulls obtained from cows fed 200 g of energy feed additive, had higher growth energy and exceeded the heifers by 6.8 kg. Morphobiochemical blood parameters under the action of energy feed additive were within the physiological norm. However, the number of red blood cells increased in the second experimental group by 1.3 and in the third experimental group — by 2.0%, the hemoglobin content was higher by 3.6 and 6.0%, respectively. The concentration of total protein averaged 75.88 g/l.Methods. The studies were carried out on dry cows when feeding an energy feed additive as part of a feed mixture to understandits effect on reproductive functions. The productivity of newborn calves was taken into account by weighing. Morphobiochemical blood parameters of dry cows were determined by generally accepted methods in the Bryansk MVL FSBI. Daily monitoring of the feed mixture intake by animals was carried out.Results. The introduction of different amounts of energy feed additives into the diet provided the need for metabolic energy of dry cows, led to an increase in the reproductive functions of cows, obtaining viable calves and high growth energy during the dairy period.
Las TIC en el desarrollo de las funciones básicas durante el proceso de enseñanza y aprendizaje de Ciencias Naturales en los estudiantes de básica superior
Authors: Freire Pazmiño Julio César 
Published: March 2022

Introducción. Considerando que los avances de la tecnología mejora del nivel de vida de las personas, al impulsar el desarrollo económico, ya que el acceso a la información y la capacidad de transferir información permiten a los individuos mejorar sus competencias personales y profesionales; Objetivo. Determinar cómo incide el uso de tecnologías de la información y comunicación en el desarrollo de las funciones básicas (atención, concentración, memoria y lenguaje) durante el proceso de enseñanza y aprendizaje de ciencias naturales en los estudiantes de básica superior (subnivel 4) en la Unidad Educativa Intercultural Bilingüe Tamboloma. Metodología. se efectuó una adaptación al modelo de evaluación propuesto por Mejía, Toala y Valverde, toma como referente criterios e indicadores que estimulan la motivación y autorreflexión, basado en el en el proceso de enseñanza aprendizaje, es trascendental mencionar que fue aplicado el software Microsoft Excel, para tabular y organizar la información numérica, además, se realizó el análisis de fiabilidad mediante el programa estadístico IBM SPSS 2.0, en el nivel de confianza se aplica el alfa de Cronbach, trabajando, con el 95% de confianza, 5% de error relativo calculado y 0,05% de significación, el Chi Cuadrado que permitió rechazar la hipótesis nula y aceptar la hipótesis alternativa. Resultados. Las competencias cognitivas incluyen el razonamiento desde el pensamiento analítico que beneficia en la comprensión de las diversas situaciones que enfrenta el educando dentro y fuera del ambiente educativo además contiene las habilidades para resolver problemas a través de la reflexión el pensamiento lógico y sistemático. Conclusión. En el área de ciencias naturales y tecnología integra los saberes, y conocimientos, activa el refuerzo de las capacidades, las competencias y destrezas habilidades necesarias que exige el mundo contemporáneo para vivir en sociedad.
Prognostic Value of Genomic Instability of m6A-Related lncRNAs in Lung Adenocarcinoma
Authors: Li Rui , Li Jian-Ping , Liu Ting-Ting , Huo Chen , Yao Jie , Ji Xiu-Li , Qu Yi-Qing 
Published: March 2022

Background: Genomic instability of N6-methyladenosine (m6A)–related long noncoding RNAs (lncRNAs) plays a pivotal role in the tumorigenesis of lung adenocarcinoma (LUAD). Our study identified a signature of genomic instability of m6A-associated lncRNA signature and revealed its prognostic role in LUAD.Methods: We downloaded RNA-sequencing data and somatic mutation data for LUAD from The Cancer Genome Atlas (TCGA) and the GSE102287 dataset from the Gene Expression Omnibus (GEO) database. The “Limma” R package was used to identify a network of regulatory m6A-related lncRNAs. We used the Wilcoxon test method to identify genomic-instability–derived m6A-related lncRNAs. A competing endogenous RNA (ceRNA) network was constructed to identify the mechanism of the genomic instability of m6A-related lncRNAs. Univariate and multivariate Cox regression analyses were performed to construct a prognostic model for internal testing and validation of the prognostic m6A-related lncRNAs using the GEO dataset. Performance analysis was conducted to compare our prognostic model with the previously published lncRNA models. The CIBERSORT algorithm was used to explore the relationship of m6A-related lncRNAs and the immune microenvironment. Prognostic m6A-related lncRNAs in prognosis, the tumor microenvironment, stemness scores, and anticancer drug sensitivity were analyzed to explore the role of prognostic m6A-related lncRNAs in LUAD.Results: A total of 42 genomic instability–derived m6A-related lncRNAs were differentially expressed between the GS (genomic stable) and GU (genomic unstable) groups of LUAD patients. Four differentially expressed lncRNAs, 17 differentially expressed microRNAs, and 75 differentially expressed mRNAs were involved in the genomic-instability–derived m6A-related lncRNA-mediated ceRNA network. A prediction model based on 17 prognostic m6A-associated lncRNAs was constructed based on three TCGA datasets (all, training, and testing) and validated in the GSE102287 dataset. Performance comparison analysis showed that our prediction model (area under the curve [AUC] = 0.746) could better predict the survival of LUAD patients than the previously published lncRNA models (AUC = 0.577, AUC = 0.681). Prognostic m6A-related-lncRNAs have pivotal roles in the tumor microenvironment, stemness scores, and anticancer drug sensitivity of LUAD.Conclusion: A signature of genomic instability of m6A-associated lncRNAs to predict the survival of LUAD patients was validated. The prognostic, immune microenvironment and anticancer drug sensitivity analysis shed new light on the potential novel therapeutic targets in LUAD.
Ferroptosis Related Genes in Ischemic and Idiopathic Cardiomyopathy: Screening for Potential Pharmacological Targets
Authors: Jiang Yufeng , Chen Ling , Chao Zhujun , Chen Tan , Zhou Yafeng 
Published: March 2022

Background: Ferroptosis is a new form of cell death recently discovered that is distinct from apoptosis, necrosis and autophagy. This article is expected to provide a new direction for the treatment of cardiomyopathy in the future by screening potential drug targets associated with ferroptosis.Methods: Differential expression analysis of GSE5406 from the Gene Expression Omnibus (GEO) database was performed using the GEO2R tool. Functional annotation of ferroptosis related genes was also performed. Then we constructed protein-protein interaction networks and identified hub genes using Cytoscape. The candidates for pharmacological compounds targeting the hub genes were screened by cMap.Results: Totally 15 ferroptosis related genes (4 upregulated and 11 downregulated) for ischemic cardiomyopathy and 17 ferroptosis related genes (13 upregulated and 4 downregulated) for idiopathic cardiomyopathy were found. The biological processes involved in these genes mainly include negative regulation of apoptotic process, flavonoid metabolic process, response to drug for ischemic cardiomyopathy and cellular response to fibroblast growth factor stimulus, negative regulation of apoptotic process, and response to drug for idiopathic cardiomyopathy. KEGG results showed that these genes were mainly involved in MAPK signaling pathway for ischemic cardiomyopathy and PI3K-Akt signaling pathway for idiopathic cardiomyopathy. We generated a co-expression network for hub genes and obtained top 10 medications suggested respectively for ischemic/idiopathic cardiomyopathy.Conclusion: Our study reveals the potential role of ferroptosis related genes in ischemic and idiopathic cardiomyopathy through bioinformatics analysis. The hub genes and potential drugs may become novel biomarkers for prognosis and precision treatment in the future.