bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex features of cutaneous microvasculature in healthy working-age people
Authors: Omelyanenko K. V. , Gorshkov A. Yu. , Fedorovich A. A. , Korolev A. I. , Dadaeva V. A. , Akasheva D. U. , Drapkina O. M. 
Published: January 2022

Aim. To study sex characteristics of cutaneous microvascular structure and function in a cohort of healthy working-age people without cardiovascular diseases.Material and methods. The study included 35 healthy men (42±4 years) and 34 women (41 ±5 years). The cardiovascular system was assessed in all patients. The microcirculatory bed of the skin was investigated by the following non-invasive methods: 1) computerized video capillaroscopy; 2) laser Doppler flowmetry; 3) photoplethysmography.Results. According to computerized video capillaroscopy in men, compared with women, there was a smaller number of both functioning capillaries (78 vs 86 capillaries/mm2, respectively (p<0,05)) and their total number (100 vs 120 capillaries/mm2, respectively (p<0,001)). Against the background of a decrease in capillary density in men, there was a higher skin interstitial hydration — 113 vs 96 gm (p<0,005) in men than in women. At the level of precapillary arterioles, where humoral tone regulation prevails. Laser Doppler flowmetry revealed lower pulse amplitude in men than in women — 0,87 vs 1,02 pf, respectively (p<0,05), which indicates a lower arterial blood inflow to exchange microvessels. Against this background, the constrictor response of precapillary arterioles to a sympathetic nervous system stimulation in men is higher than in women — 45% vs 40%, respectively (p<0,05). At the level of large arterioles, where neural tone regulation prevails, photoplethysmography revealed lower augmentation index standardized at a heart rate in men (-4,6 vs 1,7%, respectively, p<0,05), which indicates lower rigidity of muscular vessels in men.Conclusion. In working-age healthy people, sex differences are noted at all cutaneous microvascular levels, which must be taken into account when planning studies.
Long-term dynamics of the levels of anti-SARS-CoV-2 S-protein IgG antibodies in vaccinated individuals
Authors: Drapkina O. M. , Burns S. A. , Gorshkov A. Yu. , Shishkova V. N. , Ryzhakova L. N. , Litinskaya O. A. , Ivanova A. A. , Veretennikova A. V. , Bashnyak V. S. , Tatarevich E. Yu. 
Published: January 2022

In the context of the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is extremely important to study immunogenicity and immune response duration in different vaccines.Aim. As part of a prospective observational study, to study the levels of anti-SARS-CoV-2 S-protein IgG antibodies in individuals vaccinated with the Gam-COVID-Vac and CoviVac vaccines.Material and methods. The data of 93 people who completed the first 3 visits were analyzed, 23 of whom were vaccinated with the Gam-COVID-Vac vaccine and 70 people — with the CoviVac vaccine. We collected blood before the injection of vaccine doses I and II, as well as 42 days after the injection of dose I in order to quantitatively determine IgG levels. The level of anti-SARS-CoV-2 S-protein IgG antibodies was determined using the SARS-CoV-2 IgG ELISA-BEST reagent kit on the InfiniteF50 TECAN system.Results. A significant increase in anti-SARS-CoV-2 S-protein IgG antibodies was observed in those vaccinated with Gam-COVID-Vac. In the group of CoviVac vaccine, an increase in the level anti-SARS-CoV-2 S-protein IgG antibodies in absolute values was recorded, however, this increase did not reach statistical significance.Conclusion. The data obtained show that the level of anti-SARS-CoV-2 S-protein antibodies 42 days after Gam-COVID-Vac vaccination is significantly higher than after CoviVac vaccination. However, an increase in the level of IgG in both groups indicates the ability of both vaccines to stimulate the production of anti-SARS-CoV antibodies.
Recommending news in traditional media companies
Authors: Gulla Jon Atle , Svendsen Rolf Dyrnes , Zhang Lemei , Stenbom Agnes , Frøland Jørgen 
Published: January 2022

AbstractThe adoption of recommender systems in online news personalization has made it possible to tailor the news stream to the individual interests of each reader. Previous research on commercial recommender systems has emphasized their use in large‐scale media houses and technology companies, and real‐world experiments indicate substantial improvements of click rates and user satisfaction. It is less understood how smaller media houses are coping with this new technology, how the technology affects their business models, their editorial processes, and their news production in general. Here we report on the experiences from numerous Scandinavian media houses that have experimented with various recommender strategies and streamlined their news production to provide personalized news experiences. In addition to influencing the content and style of news stories and the working environment of journalists, the news recommender systems have been part of a profound digital transformation of the whole media industry. Interestingly, many media houses have found it undesirable to automate the entire recommendation process and look for approaches that combine automatic recommendations with editorial choices.
Changes in the System of Students Life Values in the Russian Far East in the Context of the Covid-19 Pandemic
Authors: Katkova Elena , Sityaeva Snezhana , Orlova Olga 
Published: January 2022

The current historical period of human history is characterized by hard challenges caused by the global COVID-19 pandemic, which inevitably leads to transformations in human consciousness and value-and-meaning sphere. Studies of this aspect are becoming increasingly topical. The article studies the value-and-meaning sphere of full-time students in the context of distance learning and forced isolation. The authors compare the results of two data slices made in 2018–2019 and 2020. The research involved 701 students aged 18–24. The first stage of the research in 2018–2019 academic year involved 295 young people (102 males and 193 females). The second stage was in May 2020 during the lockdown the number of respondents was 406 young people (85 males and 321 females). The authors of the article used E.B. Fantalova’s research conception of the correlation of «value» and «affordability» in various life spheres. The results show a significant difference between students’ pre- and post-pandemic value benchmarks. During the pandemic, we see a pronounced intra-personal conflict between a value and affordability in students’ meaningful life spheres. This gap between a need for achieving internally important values and affordability of this achievement is more significant in relation to an active life style, health, an interesting job, beauty of the nature, arts and freedom. Self-isolation has worsened internal conflicts and the feeling of psychological welfare has faded. The shift in students’ value-and-meaning priorities in the context of the pandemic requires working out new strategies of personal and vocational self-realization, and searching for ways of saving health optimal psychological resources.
Study of wound-healing activity of sodium 2-(adamantane-1-yl)-2-hydrazino-5-phenyl-4-oxobutanoate
Authors: Kuznetsov Alexander S. , Pulina Natalya A. , Chashchina Svetlana V. 
Published: January 2022

Objective. To study a wound-healing activity of the earlier synthesized compound-leader sodium 2- (adamantan-1-yl)-2-hydrazino-5-phenyl-4-oxobutenoate (1), as well as to establish the possibility of its practical application in the ointment dosage form.
Materials and methods. The substance-leader 1 was synthesized by the chemical methods described earlier. The experimental 5 % ointment composition based on an aqueous solution of sodium alginate was developed in compliance with the rules for preparing homogeneous ointments. Its effect on the healing of linear aseptic skin wounds in white rats was studied by the method of wound-tensiometry.
Results. The experimental 5 % ointment composition with compound 1 was found to significantly increase the scar tensile strength compared to control without treatment. The developed model ointment showed wound-healing activity comparable to that of the reference drug (Levomekol ointment).
Conclusions. The selected substance-leader 1 in the composition of a model 5 % hydrophilic ointment based on sodium alginate exhibits pronounced biological activity and is a candidate for further research as a potential pharmaceutical substance with complex wound-healing and anti-inflammatory property.
A Source Physics Interpretation of Nonself-Similar Double-Corner-Frequency Source Spectral Model JA19_2S
Authors: Ji Chen , Archuleta Ralph J. 
Published: January 2022

AbstractWe investigate the relation between the kinematic double-corner-frequency source spectral model JA19_2S (Ji and Archuleta, 2020) and static fault geometry scaling relations proposed by Leonard (2010). We find that the nonself-similar low-corner-frequency scaling relation of JA19_2S model can be explained using the fault length scaling relation of Leonard’s model combined with an average rupture velocity ∼70% of shear-wave speed for earthquakes 5.3 &lt; M&lt; 6.9. Earthquakes consistent with both models have magnitude-independent average static stress drop and average dynamic stress drop around 3 MPa. Their scaled energy e˜ is not a constant. The decrease of e˜ with magnitude can be fully explained by the magnitude dependence of the fault aspect ratio. The high-frequency source radiation is generally controlled by seismic moment, static stress drop, and dynamic stress drop but is further modulated by the fault aspect ratio and the relative location of the hypocenter. Based on these two models, the commonly quoted average rupture velocity of 70%–80% of shear-wave speed implies predominantly unilateral rupture.
Cartesian Meshing Spherical Earth (CMSE): A Code Package to Incorporate the Spherical Earth in SPECFEM3D Cartesian Simulations
Authors: Li Guoliang , Tao Kai , Chen Min , Li Jiaqi , Maguire Ross , Ma Xiaodan 
Published: January 2022

AbstractThe SPECFEM3D_Cartesian code package is widely used in simulating seismic wave propagation on local and regional scales due to its computational efficiency compared with the one-chunk version of the SPECFEM3D_Globe code. In SPECFEM3D_Cartesian, the built-in meshing tool maps a spherically curved cube to a rectangular cube using the Universal Transverse Mercator projection (UTM). Meanwhile, the geodetic east, north, and up directions are assigned as the local x–y–z directions. This causes coordinate orientation issues in simulating waveform propagation in regions larger than 6° × 6° or near the Earth’s polar regions. In this study, we introduce a new code package, named Cartesian Meshing Spherical Earth (CMSE), that can accurately mesh the 3D geometry of the Earth’s surface under the Cartesian coordinate frame, while retaining the geodetic directions. To benchmark our new package, we calculate the residual amplitude of the CMSE synthetics with respect to the reference synthetics calculated by SPECFEM3D_Globe. In the regional scale simulations with an area of 1300 km × 1300 km, we find a maximum of 5% amplitude residual for the SPECFEM3D_Cartesian synthetics using the mesh generated by the CMSE, much smaller than the maximum amplitude residual of 100% for the synthetics based on its built-in meshing tool. Therefore, our new meshing tool CMSE overcomes the limitations of the internal mesher used by SPECFEM3D_Cartesian and can be used for more accurate waveform simulations in larger regions beyond one UTM zone. Furthermore, CMSE can deal with regions at the south and north poles that cannot be handled by the UTM projection. Although other external code packages can be used to mesh the curvature of the Earth, the advantage of the CMSE code is that it is open-source, easy to use, and fully integrated with SPECFEM3D_Cartesian.
100 Years of Paper Seismograms from Denmark and Greenland, 1907–2008
Authors: Dahl-Jensen Trine , Lund Jacobsen Lif , Graulund Sølund Ann-Sophie , Larsen Tine B. , Voss Peter H. 
Published: January 2022

AbstractThe paper seismograms from 100 years of observations in Denmark and Greenland has since October 2021 been made available through the Danish National Archives. Five case stories illustrate the quality and variation of the seismograms, and the historical context of operation of the stations. (1) The earliest recorded earthquake in the archive is recorded at GDH station in Greenland, where the 1907 Mw 7.2 earthquake in Tajikistan is recorded on smoked paper. (2) The first Danish earthquake is a local event close to Copenhagen in 1930. (3) We have illustrated the 50 megaton nuclear explosion in Novaya Zemlya in 1961—the largest nuclear test explosion ever. (4) The M 9.2 earthquake in Alaska in 1964 recorded on several instruments at COP. (5) A local earthquake in northeast Greenland recorded both on paper on World-Wide Standard Seismographic Network instruments and digitally on a modern broadband instrument.
Pre-analytical specimen labelling and processing errors in the ICU
Authors: Nguyen Long , Microys Sherissa 
Published: January 2022

Introduction: Specimen rejections have been associated with increased in-hospital stay and cost. The majority of errors occur in the pre-analytic phase. Specimen rejection can lead to high rate of recollection, delay in result availability, and high rate of test abandonment. These factors affect patient care and safety.
Methods: This study conducted a retrospective review of Patient Safety Learning System (PSLS) reports for the intensive care unit (ICU) at The Ottawa Hospital General Campus (TOH) between 2010 and 2018, and a prospective review using interviews, surveys, and process mapping.
Results: From 2098 PSLS reports, 52.6% were related to laboratory specimen collection and processing (pre-analytic phase). Specimen mislabelling with the wrong patient identifier accounted for 9.8% of pre-analytical error reports, while 16.4% of errors were due to non-sufficient quantity (NSQ) of specimen. 12.2 % of pre-analytical error reports involved cytology specimens.
Conclusions: Pre-analytical errors are not only costly and resource draining, but may also place a burden on patients. Areas where errors were found include labels and requisitions stored in bedside cabinets, inconsistencies between specimen labels and requisitions, out-dated and difficult to access laboratory manuals, and non-sufficient quantity specimen collection. In the future we hope to start new initiatives to tackle these issues to improve patient safety and hospital efficiencies. This includes the development of a website for the laboratory manual, so that it is more easily accessible and user-friendly. With a new electronic medical record (EMR) system at TOH in 2019, we will explore the affects of pre-analytical processing of specimens.
Placing Priority on Faith in Providing a Foundation for Children to Face Puberty
Authors: Yuniarti Falasifah Ani , Ismail Djauhar , Prabandari Yayi Suryo , Werdati Sri 
Published: January 2022

Background: Children will experience puberty at the age of 9-15 years, influenced by several factors. Various changes require children to be ready to face them. Teachers carry out preparations, especially those who teach in elementary schools.Objective: This research is qualitative research that aims to explore the preparation made by teachers in preparing for puberty. A total of nine Islamic-based school teachers were interviewed at their schools.Methods: In-depth interviews were conducted using structured open questions. The analysis employed Van Manen’s method.Result: This study raised three themes: the teacher's perception of student development, how the teacher prepares for puberty, and the problems faced in educating children to face puberty.Conclusion: it is necessary to develop a model that can prepare children to enter puberty.
Monitoring of bone fractured healing using biochemical markers among patients attending federal teaching hospital abakaliki and bone setter home in onueke ebonyi state, Nigeria
Authors: Okezie A O , Edeogu C O , Onweh D A , Ogbodo E C , Okebalama A A , Izuchukwu E C O , Aikpitanyi-Iduitua G A , Nwanguma D E 
Published: January 2022

The monitoring of bone fractured healing using Alkaline phosphatase, calcium ion and inorganic phosphate was evaluated among patients with fractured bone in two different centers, Alex Ekwueme Federal University Teaching Hospital Abakaliki and Bone Setters Home, Onueke, Ezza in Ebonyi State between August 2017 and September 2018. : A total of 90 adults patients from 18 years to 78 years were examined using phenolphthalein monophosphate colorimetric end point method. Out of the 90 patients, 30 were healthy normal subjects, another 30 were patients in AE-FUTHA while the remaining 30 patients were in bone setter home. : Patients without bone fracture had the least mean serum level of alkaline phosphatase, 28.5 ± 9.0µl followed by those admitted in bone setter home with a mean serum level of 38.2±17.9µl while patients admitted in AE-FUTHA had the highest mean serum level of 41.4±6.5µl (P&#60;0.05). The mean serum level of calcium was significantly higher 10.9± 2.6mg/dl in healthy normal patients compared to mean serum level of 9.2 ± 3.3mg/dl and 7.4 ± 1.3mg/dl for patients admitted in AE-FUTHA and bone setter home respectively. The mean serum level of inorganic phosphate indicate that patients admitted in bone setter home had the highest mean of 4.1 ± 1.0mg/dl followed by patients admitted in AE-FUTHA 3.4 ± 0.2mg/dl while that of healthy normal individuals had the least mean serum level of 3.2 ± 0.5mg/dl. : Out of the three parameters examined, alkaline phosphatase test was more precise, reliable and patient doctor friendly; hence it can be used as a veritable tool to monitor the process of bone fracture healing effectively.
Perception of 1 MBBS students about educational environment through ‘DREEM’ questionnaire
Authors: Rukadikar Atul R , Rukadikar Charushila , Jaiswal Nitesh 
Published: January 2022

In an undergraduate (UG) medical education program, the educational environment is a critical factor of effective outcomes. Because it is a proven approach for this assessment in medical schools, the Dundee Ready Education Environment Measure (DREEM) was employed in this study.1. To assess the student’s perception of the educational environment using the Dundee Ready Educational Environment Measure (DREEM) questionnaire among 1st-year undergraduate medical students. 2. To identify the strengths and weaknesses in student’s educational environment.A cross-sectional study was carried out among first-year medical students. To obtain student perceptions of the educational environment, a widely accepted DREEM questionnaire was employed. The DREEM questionnaire is divided into five sections, each of which has 50 statements that are rated on a five-point Likert scale (0–4). The questionnaire was distributed to consented individuals (n=150) after receiving ethical approval. The filled questions were collected and statistically evaluated. The data were presented as mean and standard deviation, frequency, and percentages. The responses were analyzed and interpreted using McAleer and Roff's practical recommendations.There was a 100% response rate. The average DREEM score was 124.9 ± 50 (62.46%). Among the five DREEM dimensions, students' perceptions of learning received the highest score (65.63%), while students' perceptions of the environment received the lowest (59.31 %).Statements “I have good friends in this college”, “My social life is good” and “I am confident about passing this year” scored ≥ 3 of 4 points.“A more positive than negative perception,” according to the total mean DREEM score. Student confidence, social life, instructor knowledge, encouragement to participate in a teaching session, teacher preparedness, and having excellent friends on campus received the most positive answers. However, there is space for development in areas where there is a lack of expertise, such as student ennui and creative teaching.
Redes de Imigração Síria no Brasil e Criação de novos Negócios
Authors: Diniz Gislene Cordeiro da Silva , Guimarães Liliane de Oliveira , Falcão Roberto Pessoa de Queiroz , Cruz Eduardo Picanço 
Published: January 2022

Objetivo: O objetivo deste trabalho é analisar como redes étnicas apoiam e influenciam na criação de novos negócios.
Método: Pesquisa de natureza qualitativa e método estudo de casos múltiplos. Entrevistas em profundidade com 24 refugiados sírios, estabelecidos na cidade do Rio de Janeiro, Belo Horizonte e região metropolitana. As entrevistas foram realizadas entre agosto de 2017 a maio de 2019.
Principais resultados: Os resultados apontam que as redes étnicas influenciaram e disponibilizaram recursos que contribuíram com o processo empreendedor. Constatou-se a importância da atividade empreendedora para a geração de renda dos refugiados, principalmente em negócios relacionados à sua cultura de origem. Os achados confirmaram que as estruturas sociais, são detentoras de um volume significativo de capital social, que permite o acesso a diversos tipos de recursos que promovem o processo empreendedor.
Relevância/originalidade: Este artigo contribui para o debate do empreendedorismo imigrante realizado por refugiados em solo brasileiro, apontando para a importância e os efeitos das redes sociais e do capital social no desenvolvimento de novos negócios
Contribuições teóricas/metodológicas: Maior compreensão sobre dinâmica local do empreendedorismo imigrante, redes sociais e capital social. Amplia os modelos conceituais e teóricos estabelecidos no estudo do processo empreendedor Imigrante.
Contribuições sociais: Importância da atividade empreendedora de imigrantes na geração de renda e no desenvolvimento da economia local. Os achados revelam a necessidade de políticas públicas que apoiem o empreendedorismo imigrante no Brasil.
Comparison of the effect of marine-derived omega-3 fatty acids (n-3 FAs) as an adjunct to a non-steroidal inflammatory drug (NSAID) therapy vs NSAID therapy alone, for dogs with osteoarthritis
Authors: Wong Lok Yee Stephanie , Govendir Merran 
Published: January 2022

PICO question
Does treatment with a non-steroidal anti-inflammatory drug (NSAID) with supplementation of marine-derived omega-3 fatty acids (n-3FAs) compared to the NSAID alone, result in an increased ability to exert force by the osteoarthritic limb(s) of dogs or alleviate other measures of osteoarthritis?

Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
Two prospective, block-randomised, clinical trials
Strength of evidence
None
Outcomes reported
Kwananocha et al. (2016) investigated administration of carprofen supplemented with marine-derived n-3 FAs, to carprofen alone, administered over 4 weeks. Vijarnsorn et al. (2019) investigated administration of firocoxib supplemented with n-3FA, to firocoxib alone, for 4 weeks. There were no statistical differences between treatment groups at week 2 and week 4 post-treatment for either study. Both studies also reported orthopaedic assessment score (OAS) based on scoring the extent of patient lameness and pain in the affected joint. There were no statistical changes in OASs between treatment groups at week 2 or week 4 post-treatment for either study
Conclusion
There is no evidence that marine-derived n-3 FAs provide additional benefit when used as adjunctive agents with NSAIDs for the treatment of canine osteoarthritis

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.