bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects and mechanism of Kudingcha on obesity
Authors: Sui Xiaohui , Liu Jia , Gong Li , Zhang Lei 
Published: November 2022

Abstract

Obesity is the world's most high-profile public health problem. Kudingcha has been used in traditional medicine because of its antioxidant, anti-inflammatory and weight loss properties. Quercetin and kaempferol are the main components rich in Kudingcha that are effective against obesity. Therefore, we used the method of network pharmacology to study the effects of quercetin and kaempferol to HepG2 cells on obesity. We obtained 20 hub genes through PPI results and the Cytoscape plug-in cytoHubba. The top 10 genes were found eventrully by GO and KEGG enrichment analysis. The results showed that the insulin resistance, PI3K-Akt signaling pathways and adipocytokine signaling pathway might be the central pathways associated with the treatment of obesity by kudingcha. Next, we used Real-Time PCR to detect the expression levels of ISNR, SLc2a4 and APOE genes to study its mechanism. The results showed that compared with the blank group, the expression of ISNR and SLc2a4 increased and the expression of APOE decreased. Our experiments confirmed that Kudingcha contains compounds that can improve insulin resistance and obesity. This can provide a reference for further research and application of Kudingcha in the treatment of obesity.
On potential challenges of V2X sidelink relaying: Link-level and system-level simulation with neural network assisted
Authors: Zhao Chonghao , Wu Gang 
Published: November 2022

Abstract
The ever-increasing demand for high data rates and high connection densities in the vehicle communication network, along with the widespread adoption of radio access over the Third Generation Partnership Project (3GPP) standard, has been a major driver of a large amount of research on cellular vehicle-to-everything (C-V2X) communication. Additionally, Wi-Fi and other wireless communication technology work on the unlicensed band has undergone booming development due to the proliferation of handheld devices over the years. It is, therefore, likely that C-V2X users dedicated band on the 5.9 GHz spectrum may suffer from both co-channel and adjacent channel interference, which cannot be negligible, especially in urban scenarios. To this end, 3GPP has standardized relay technology in New Radio (NR) V2X sidelink to confront such engineering concerns. Placing relay nodes on vehicles is a promising approach to save power and energy, as well as extend the transmission range under interference. In this paper, through a link-level and system-level simulation study, we implement parameter optimization and performance evaluation in relaying scenarios. Motivated by the recent success of deep learning, a novel neural network is further introduced to detect and classify interference signals of different protocols so that the sidelink transceiver can adopt specific schemes to mitigate interference respectively. Simulation results provide direct insight into the system performance in relay-assisted cases and reveal that the interference incurred by NR on unlicensed spectrum (NR-U) signal is the most intractable which may bring potential challenges in future works.
In vitro effects of the combination of serotonin, selenium, zinc, vitamin D and E supplementation on human sperm motility
Authors: Yılmazer Yasemin , Moshfeghi Elnaz , Cetin Fadime , Findikli Necati 
Published: November 2022

AbstractBackground Infertility affects 15% of all couples worldwide. According to recent research, 50% of cases of infertility are solely due to male factors. A decrease in motility is directly related to infertility. The purpose of this study was to see how sperm motility was affected by the combination of serotonin (5-HT), selenium (Se), zinc (Zn), vitamin D, and vitamin E supplementation. Methods and results Semen samples were incubated for 75 minutes at 37°C in media containing varying concentrations of 5-HT, Se, Zn, vitamin D, and E. Sperm concentration and motility were assessed at the end of the incubation. Calculations were made for each supplement to determine the proportions of fast progressive (+ 4), slow progressive (+ 3), non-progressive (+ 2), and immotile (+ 1) sperm cells. There was a significant improvement in fast progressive motility when compared to the control groups. 5-HT (200 µM), Se (2 µg), Zn (10 µg), vitamin D (100 nM), and vitamin E (2 mmol) concentrations have also been shown to increase fast progressive sperm motility. Three different mixtures were tested for their effects on sperm motility, and the one with the highest serotonin content was also found to have higher sperm motility than the others. While the mean + 4 sperm motility in the control group was 5.26%, it increased to 16.45% in the first mixture. Conclusion Sperm motility is improved by incubating with 5-HT, Se, Zn, Vitamin D, and E. These molecules may enhance the success of assisted reproduction techniques when present in sperm preparation media.
A Discrete Choice Experiment to Elicit Preferences for a Liver Screening Programme in Queensland, Australia: A Mixed Methods Study to Select Attributes and Levels
Authors: Allen Michelle , Doran Rachael , Brain David , Powell Elizabeth E , O’Beirne James , Valery Patricia C , Barnett Adrian , Hettiarachchi Ruvini , Hickman Ingrid J , Kularatna Sanjeewa 
Published: November 2022

Abstract
Background
In Australia, the overall prevalence of liver disease is increasing. Maximising uptake of community screening programmes by understanding patient preferences is integral to developing consumer-centred care models for liver disease. Discrete choice experiments (DCEs) are widely used to elicit preferences for various healthcare services. Attribute development is a vital component of a well-designed DCE and should be described in sufficient detail for others to assess the validity of outcomes. Hence, this study aimed to create a list of potential attributes and levels which can be used in a DCE study to elicit preferences for chronic liver disease screening programmes.
Methods
Key attributes were developed through a multi-stage, mixed methods design. Focus groups were held with consumers and health care providers on attributes of community screening programmes for liver disease. Stakeholders then prioritised attributes generated from the focus group in order of importance via an online prioritisation survey. The outcomes of the prioritisation exercise were then reviewed and refined by an expert panel to ensure clinically meaningful levels and relevance for a DCE survey.
Results
Fifteen attributes were generated during the focus group sessions deemed necessary to design liver disease screening services. Outcomes of the prioritisation exercise and expert panel stages recognised five attributes, with three levels each, for inclusion in a DCE survey to elicit consumer preferences for community screening for liver disease. This study also highlights broader social issues such as the stigma around liver disease that require careful consideration by policy makers when designing or implementing a liver screening programme.
Conclusions
The attributes and levels identified will inform future DCE surveys to understand consumer preferences for community screening programmes for liver disease. In addition, the outcomes will help inform the implementation of the LOCATE-NAFLD programme in real-world practice, and could be relevant for other liver and non-liver related chronic disease screening programmes.
A ResNet-LSTM Hybrid Model for Predicting Epileptic Seizures using a Pretrained Model with Supervised Contrastive Learning
Authors: LEE DOHYUN , KIM BYUNGHYUN , MIN KYEONGYUK , CHONG JONGWHA , KIM TAEJOON , JUNG KIYOUNG , JOE INWHEE 
Published: November 2022

Abstract
In this paper, we propose a method for predicting epileptic seizures using a pre-trained model utilizing supervised contrastive learning and a hybrid model combining Residual Networks (ResNet) and Long Short-Term Memory (LSTM). The proposed training method includes three phases: pre-processing, pre-training as a pretext task, and training as a downstream task. In the pre-processing phase, Short Time Fourier Transform (STFT) was used to convert the data into a spectrogram image with time and frequency information to compensate for the complexity and irregularity of the Electroencephalography (EEG) data, which made data analysis difficult. In the pre-training phase, band-stop filter and temporal cutout were applied to the original data to create augmented data, which were then pre-trained with a ResNet and supervised contrastive loss model to train the representation of the spectrogram image. During the training phase, image features and time information were extracted from a hybrid model consisting of ResNet initialized as weight values of a pre-trained model and LSTM. CHB-MIT and Seoul National University Hospital (SNUH) were used to validate the proposed method, and generalization performance was confirmed using Leave-one-out cross-validation. From the experimental results measuring accuracy, sensitivity, and False Positive Rate (FPR), CHB-MIT was 91.90%, 89.64%, 0.058 and SNUH was 83.37%, 79.89%, and 0.131. The experimental results demonstrate that the proposed method outperforms the conventional methods.
Effect of levothyroxine on gestational hypertension and pre-eclampsia in subclinical hypothyroidism, hypothyroidism, and thyroid autoimmunity: a systematic review and meta-analysis
Authors: Goodarzi-Khoigani Masoomeh , Aminorroaya Ashraf , Mohammadi Raziyeh 
Published: November 2022

AbstractBackground We assessed the effect of levothyroxine (LT4) therapy on gestational hypertension (GH) and preeclampsia (PE) in subclinical hypothyroidism (SCH), overt hypothyroidism (OH), or thyroperoxidase antibody (TPOAb) positivity. Methods Scopus, Medline, Science Direct, ProQuest, Google Scholar, and Cochrane library were scientifically searched for randomized controlled trials (RCTs), cohorts, and case-control studies assessing the effect of levothyroxine on incidences of GH or/and PE compared to control or placebo up to November 2022. Results After LT4 therapy in women with SCH, the ORs of GH and PE were not significantly different from compared groups; also, in OH, and studies recruited both SCH or OH subjects. LT4 reduced GH in TPOAb + women compared with a non-treated group, while after treatment in TPOAb + versus TPOAb- women, the ORs of GH and PE did not change significantly. Conclusion After LT4 therapy, the ORs of GH and PE did not significantly change in SCH, OH, SCH or OH participants compared to controls; also, in TPOAb + compared to TPOAb- equivalents. Reduction of GH in treated TPOAb + versus non-treated TPOAb + women refers to the importance of TPOAb determination. Insignificant changes of both ORs in treated SCH compared to untreated indicates whether SCH increases the incidence of GH and PE.
Influence of Joint Volume on Range of Motion after Arthroscopic Rotator Cuff Repair
Authors: Kim Jung-Han , Min Young-Kyoung , Kim Dae-Yoo , Park Jun-Ho , Seo Young-Chae , Seo Won-Seok 
Published: November 2022

Abstract
Background: Capsular contracture is a well-known etiology in the primary stiff shoulder; thus capsular contracture and resultant decreased joint volume could lead to postoperative stiffness, which is a commonly reported morbidity after arthroscopic rotator cuff repair (ARCR). The purpose of this study was (1) to quantify the joint volume (total joint volume and each half compartmental volume) using computed tomography arthrography (CTA) and (2) to demonstrate the relationship between joint volume and postoperative range of motion (ROM) after ARCR
Materials and Methods: Eighty-three patients (60 ± 5.11 years, men=26, women=57) who had undergone ARCR between January 2015 to December 2020 due to small to medium full-thickness tear and followed by CTA 6 months postoperatively were retrospectively reviewed. An image reconstruction program (3D Slicer, version 4.11.2 software) was used to calculate the joint volume (total joint volume and four half compartment joint volumes; anterior, posterior, superior, and inferior). For shoulder ROM, data including scaption (Sc), external rotation on side (ERs), external rotation at 90° (ER90), and internal rotation on back (IRb) were collected 6 months postoperatively. An evaluation of the correlation between joint volume and each shoulder motion was performed.
Results: There were moderate correlations between the total joint volume and each motion (Sc: Pearson coefficient, 0.32, p=0.0047; ERs: Pearson coefficient, 0.24, p=0.0296; ER90: Pearson coefficient, 0.33, p=0.0023; IRb: Pearson coefficient, 0.23, p=0.0336). Among the half compartments, the posterior half (Sc: Pearson coefficient, 0.34, p=0.0016; ERs: Pearson coefficient, 0.21, p=0.0493; ER90: Pearson coefficient, 0.37, p=0.0006; IRb: Pearson coefficient, 0.25,p=0.0217) and inferior half (Sc: Pearson coefficient, 0.31, p=0.0038; ERs: Pearson coefficient, 0.21, p=0.0483; ER90: Pearson coefficient, 0.31, p=0.0047; IRb: Pearson coefficient, 0.25, p=0.0254) showed moderate correlations with each shoulder motion.
Conclusion: Total joint volume, posterior half compartment joint volume, and inferior half compartment joint volume were related to postoperative ROM after ARCR. Perioperative methods to increase the joint volume, especially the posterior part and inferior part of the capsule may prevent postoperative stiffness after ARCR.
Level of Evidence: Level III; Retrospective Case-Control Study
Successful surgical treatment of post-myomectomy uterine diverticulum: A case report
Authors: Kawatake Rina , Maebayashi Aki , Nishimaki Haruna , Nagaishi Masaji , Kawana Kei 
Published: November 2022

Abstract
Background: Uterine diverticulum is classified into congenital and acquired types. The acquired type is caused by caesarean scar syndrome, which occurs after caesarean section. There are no detailed reports on diverticulum after enucleation of uterine fibroids. Most cases are treated with hysteroscopy or laparoscopy, but a management consensus is lacking. We managed a patient with a uterine diverticulum, which had formed after uterine myoma enucleation, by combining hysteroscopic and laparoscopic treatments.
Case presentation: The patient was a 37-year-old Japanese woman, G1P0. A previous doctor had performed abdominal uterine myomectomy for a pedunculated subserosal uterine myoma on the right side of the posterior wall of the uterus near the internal cervical os. Menstruation had resumed postoperatively, but a small amount of dark-red bleeding persisted. MRI two months after the myomectomy revealed a diverticulum-like structure 3 cm in diameter, communicating with the uterine lumen, on the right side of the posterior wall of the uterus. Under suspicion of uterine diverticulum after uterine myoma enucleation, the patient sought treatment at our hospital approximately four months after the myomectomy. Through a flexible hysteroscope, a hole was observed, hysterosalpingography showed a fistula opening slightly above the internal cervical os in the posterior wall of the uterus and a contrast-enhanced pocket, measuring approximately 3 cm, in front of it. Uterine diverticulum following enucleation of a uterine myoma was diagnosed, and surgery was thus deemed to be necessary. The portion entering the fistula on the external cervical os side was resected employing a hysteroscope. Intra-abdominal findings included a 4-cm mass lesion on the posterior wall on the right side of the uterus. The mass was opened, and the cyst capsule was removed. A 5-mm fistula was detected and was closed with sutures. Re-suturing was not performed after dissection of the right round ligament, due to tension. The postoperative course has been good, to date, with no recurrence.
Conclusion: Even after myomectomy, the occurrence site may develop a pathological condition similar to caesarean scar syndrome. Such lesions can be treated by incorporating a method similar to the that used for caesarean scar syndrome.
Analysis of the sources of inequalities in pregnant women's access to essential medicines in Cameroon: A decomposition approach
Authors: Anya Saturnin Bertrand Nguenda , Nchintouo Yousofou Ndayou , Nzepang Fabrice 
Published: November 2022

Abstract
This article aims to identify the sources of inequalities in pregnant women's access to essential medicines in Cameroon. We mobilize data from the fifth Cameroon Demographic and Health Survey (CDHS) (2018), conducted by the National Institute of Statistics (INS). After measuring the degree of inequality through the concentration index, we used the decomposition method of Wagstaff et al. (2003). The results show that the CI calculations by groups of individuals reveal the existence of important determinants of inequality in access to essential medicines to the disadvantage of pregnant women in poor households and contribute to shares that vary between 24.25% and 69.57%. The factors that contribute most to reducing these inequalities are the level of education, insurance coverage and marital status of pregnant women at 69.57%, 56.81% and 22.33% respectively. In other words, if wealth had been distributed equally, inequalities in pregnant women's access to essential medicines would remain largely due to inequalities related to education, insurance uptake and marital status of pregnant women.
The value of Clinical-and DWI-based Radiomics Nomogram to predict Pathologic Upgrading in Biopsy-Proven Endometrial Cancer
Authors: Yue Xiaoning , Wu Jingjing , Wang Chengwei , He XiaoYu 
Published: November 2022

Abstract
Background: It is important for biopsy formal endometrial cancer patients, especially young patients of childbearing age to determine the preservation of fertility and predict pathological escalation.
Purpose: This study's goal was to determine the viability and effectiveness of a non-invasive quantitative imaging evaluation model built using the Diffusion Weighted Image (DWI) technique and based on Radiomics signatures and clinical parameters Analysis to evaluate Endometrial Cancer (EC) with Biopsy-Proven Pathologic Upgrading.
Method: From January 2018 to December 2021, a total of 76 patients with endometrial cancer who had undergone surgery for the disease were retrospectively recruited (training cohort, n = 53; validation cohort, n = 23). The diffusion-weighted image (DWI) served as the source for the Radiomics features. All images were imported into 3D-slicer for whole tumor Segmentation and were used for radiomics feature extraction. Radiomic features were selected in target tumor volumes to build Radscore using the least absolute shrinkage and selection operator (LASSO) and Cox regression analysis Logistic regression, Next building a combined model incorporating rad-scores and clinical risk factors, compared with Radscore model, the clinical model. The models were evaluated by the receiver operating characteristic curve, and calibration curve as well as verified the model in the verification group.
Results: AUC for identifying non-pathologic upgrading and pathologic upgrading in the training cohort was 0.606 and in the validation cohort was 0.708, Three of the 107 texture feature were retrieved and 3 parameters were preserved to create the Radscore. With the incorporation of clinical risk factors, the nomogram's AUC for the training and validation cohorts were 0.870 and 0.808, respectively. Both values were significantly higher than the AUC of the clinical model in these cohorts (0.830 and 0.815). The nomogram's training cohort and validation cohort's sensitivity and specificity were 0.938, 0.730, 0.900, and 0.769, respectively. The calibration curves for the nomogram had a good agreement.
Conclusions: The Nomogram based on the Radiomics-clinical model in predicting Pathologic Upgrading in Biopsy-Proven Endometrial Cancer with high discriminatory ability.
Factors Influencing the Wearing of Masks Among the Elderly During COVID-19 and Their Root Causes in Remote Rural China: A Qualitative Study
Authors: Liu Yunlai , Huang Chunyan 
Published: November 2022

Abstract
During the COVID-19 pandemic, the criticism of the elderly not wearing masks on Chinese social media has continued to this day, but the research on how to understand the elderly group's use of masks and the factors that affect the response to the epidemic is indeed lacking. This study aimed to address this topic, evaluate the factors that affect the mask-wearing behavior of the elderly in rural areas in the context of the epidemic, and dig out the root causes of these influencing factors from a social structural perspective. Through participant observation and semi-structured interviews with 15 elderly people in a remote village in central China, it was found that factors such as access to epidemic information, perceptions of masks, physical, illnesses and labor habits, and intergenerational social interactions are the main factors affecting the elderly. The key to judging the risk of the epidemic and whether to wear a mask is a significant disconnect from the symbolic meaning of politicizing, moralizing and legalizing masks in China's epidemic prevention and control. The root cause lies in the asymmetry of information channels between the elderly farmers and urban residents who are at the edge of the epidemic prevention and control system, the lack of shared code about the epidemic between the younger generation and the elderly in rural areas, and the dominant prevention and control policies and public health concepts ignore the underlying logic of the rural elderly. Together, they lead to the persistence of dynamic conflicts between the elderly and prevention measures. The analysis of such factors and structural contradictions reminds policymakers and mainstream society to be more tolerant of the rural elderly and take differentiated measures to care for and protect their health.
Promotion of Physical Activity-Related Health Competence and the Influence on Leisure-Time Physical Activity and Health-Related Quality of Life in Office Workers
Authors: Blaschke Simon , Carl Johannes , Pelster Klaus , Mess Filip 
Published: November 2022

Abstract
Background:Office workers (OWs) are at risk of low levels of health-enhancing physical activity (HEPA) and impaired health-related quality of life (HRQOL). Interventions based on physical activity-related health competence (PAHCO) aim to facilitate long-term changes in HEPA and HRQOL. However, these assumptions rely on the changeability and temporal stability of PAHCO and have not been tested empirically. This study therefore aims to test the changeability and temporal stability of PAHCO in OWs within an interventional design and to examine the effect of PAHCO on leisure-time PA and HRQOL.
Methods: 328 OWs (34% female, 50.4 ± 6.4 years) completed an in-person, three-week workplace health promotion program (WHPP) focusing on PAHCO and HEPA. The primary outcome of PAHCO as well as the secondary outcomes of leisure-time PA and HRQOL were examined at four measurement points over the course of 18 months in a pre-post design.
Results: PAHCO displayed a substantial increase from the baseline to the time point after completion of the WHPP (β = 0.44, p < 0.001). Furthermore, there was no decrease in PAHCO at the first (p = 0.14) and the second follow-up measurement (p= 0.56) compared with the level at the end of the WHPP. In addition, the PAHCO subscale of PA-specific self-regulation (PASR) had a small to moderate, positive effect on leisure-time PA (β = 0.18, p < 0.001) and HRQOL (β = 0.26, p < 0.001). The subscale of control competence for physical training (CCPT) also had a positive small to moderate effect on HRQOL (β = 0.22, p < 0.001).
Conclusion: The results substantiate PAHCO’s theoretical characteristics of changeability and temporal stability, and underline the theoretically postulated effects on leisure-time PA and HRQOL. These findings highlight the potential of PAHCO for intervention development, which can be assumed to foster long-term improvements in HEPA and HRQOL in OWs.
Trial Registration: The study was retrospectively registered in the German Clinical Trials Register, which is an approved Primary Register in the WHO network, at the 14/10/2022 (DRKS00030514).