bluuebunny/crossref_metadata_2025_split huggingface dataset:
A adolescência negligenciada: múltiplos olhares
Authors: Ferreira Ana Lúcia , Garcia Joana , Cardoso Marta Rezende 
Published: February 2022

Neste artigo a adolescência é apresentada a partir de múltiplas dimensões que a caracterizam, fundamentada por formulações de distintos, porém complementares, campos disciplinares sobre essa experiência de vida. A proteção do adolescente é considerada uma atribuição coletiva, incluindo, além da auto proteção, um amplo conjunto relacional e institucional com seus recursos diferenciados, necessários e desejáveis para o asseguramento da qualidade de vida. Tendo como foco a negligência, em suas diferentes figuras, a adolescência é explorada em sua dimensão relacional, segundo a perspectiva de três áreas: a medicina, o serviço social e a psicanálise. O artigo é finalizado com um relato de atendimento produzido pelas autoras, inspirado em demandas cotidianas de uma unidade de saúde, envolvendo uma adolescente em situação marcada por formas distintas de negligência, reflexão na qual se evidencia a riqueza de uma análise interdisciplinar acerca das temáticas exploradas.
As crianças e seus mil dias: reflexões entre saúde e educação
Authors: Corsino Patricia , Cunha Antônio Ledo 
Published: February 2022

Este artigo se propõe a estabelecer um diálogo entre Saúde e Educação Infantil. Toma como ponto de partida questões que dizem respeito aos primeiros mil dias das crianças. A primeira parte trata da origem dos mil dias, apresenta o olhar da saúde sobre este período, define atenção integral e discute o marco legal da primeira infância que se propõe a articular politicas Intersetoriais. A segunda parte trata da educação como um direito que abarca outros direitos. Discute a qualidade da oferta da Educação Infantil para o desenvolvimento integral das crianças, a não dissociação entre o cuidar e educar, traz questões para discutir o desenvolvimento das crianças nos primeiros anos de vida e a docência na Educação Infantil. Na terceira parte conclui com indagações para as políticas voltadas para a primeira infância, com ênfase nos primeiros mil dias. Politicas que são essenciais para o pleno desenvolvimento das crianças, para o aprimoramento das sociedades e diminuição de desigualdades. Políticas que devem integrar várias áreas do conhecimento, sendo essencial a integração entre a área da saúde e da educação.
PENGARUH LINGKUNGAN KERJA DAN DISIPLIN KERJA TERHADAP KINERJA KARYAWAN PT. INFOMEDIA NUSANTARA BAGIAN CALL CENTER TELE ACCOUNT MANAGEMENT (TAM) TELKOM BANDUNG
Authors: Sari Dewi Puspita , Megawati Imelda , Heriyanto Imam 
Published: February 2022

This research aims to find and analyze the impact of the work environment and work discipline on employee performance. This study uses descriptive analysis and verification analysis with 75 respondents. Besides, this study uses path analysis. The result shows that the work environment is adequate, the result of the work discipline is acceptable, and employee performance is decent. The direct and indirect effect of the work environment on performance is 0,458. The direct and indirect effect of work discipline on performance is 0,303. The entire effect is 0,761. Coefficient determination is 76,1%, and the rest is 24,0% from the other variables that affect employee performance, but they are not analyzed in this study.
Keywords: work environment, work discipline, employee performance.
Language
Authors: Achour Kallel Myriam , Guellouz Mariem , Håland Eva Marie , Guth Stephan 
Published: February 2022

An array of Egyptian and Tunisian lifeworlds in 2016.
This entry merges earlier country-specific versions, published as “ʿĀmmiyya” (Egypt), by Eva Marie Håland, and “Dérja” (Tunisia), by Myriam Achour Kallel and Mariem Guellouz, in JAIS 17 (2017): 463-65 and JAIS 17 (2017): 482-83, respectively.
Metabolomics Distinction of Cigarette Smokers from Non-Smokers Using Non-Stationary Benchtop Nuclear Magnetic Resonance (NMR) Analysis of Human Saliva
Authors: C. Percival Benita , Wann Angela , Taylor Sophie , Edgar Mark , Gibson Miles , Grootveld Martin 
Published: February 2022

Implementations of high-field nuclear magnetic resonance (NMR) facilities into metabolomics studies are unfortunately restricted by their large dimensions, high costings, and specialist technical staff requirements. Therefore, here the application and practical advantages offered by low-field (60 MHz), compact NMR spectrometers for probing the metabolic profiles of human saliva was explored, as was their value in salivary metabolomics studies. Saliva samples were collected from cigarette smoking (n = 11) and non-smoking (n = 31) human participants. 1H NMR spectra were acquired on both low-field (60 MHz) and medium-field (400 MHz) spectrometers. Metabolomics analyses were employed to evaluate the consistencies of salivary metabolite levels determined, and their abilities to distinguish between smokers and non-smokers. Low-field 1H NMR analysis detected up to 15, albeit permitted the reliable quantification of 5, potentially key diagnostic biomolecules simultaneously (LLOQ values 250–400 μmol/L), although these were limited to those with the most prominent resonances. Such low-field profiles were also found to be suitable for salivary metabolomics investigations, which confirmed the successful discrimination between smoking and non-smoking participant sample donors. Differences observed between these groups were largely ascribable to upregulated salivary levels of methanol, and its metabolite formate, in the smoking group, but higher smoking-mediated concentrations of acetate, propionate and glycine may arise from a diminished salivary flow-rate in these participants. In conclusion, determination of salivary biomolecules using low-field, benchtop 1H NMR analysis techniques were found to be valuable for bioanalytical and metabolomics investigations. Future perspectives for the applications of this non-stationary NMR technique, for example for the on-site ‘point-of-care’ testing of saliva samples for diagnostic oral disease screening purposes at dental surgeries and community pharmacies, are considered.
CFD Combustion Simulations and Experiments on the Blended Biodiesel Two-Phase Engine Flows
Authors: Atgur Vinay , Manavendra Gowda , Pandurangarao Desai Gururaj , Nageswara Rao Boggarapu 
Published: February 2022

Biodiesels are the promising sources of alternative energy. Combustion phenomenon of blended biodiesels differs to those of diesel due to changes in physio-chemical properties. Experimental investigations are costly and time-consuming process, whereas mathematical modeling of the reactive flows is involved. This chapter deals with combustion simulations on four-stroke single-cylinder direct injection compression ignition engine running at a constant speed of 1500 rpm, injection timing of 25° BTDC with diesel and 20% blend of Jatropha biodiesel. Standard finite volume method of computational fluid dynamics (CFD) is capable of simulating two-phase engine flows by solving three-dimensional Navier–Stokes equations with k-ε turbulence model. Combustion simulations have been carried out for half-cycle by considering the two strokes compression and expansion at zero load condition. The model mesh consists of 557,558 elements with 526,808 nodes. Fuel injection begins at 725° and continues till 748° of the crank angle. Charge motion within the cylinder, turbulent kinetic energy, peak pressure, penetration length, and apparent heat release rate are analyzed with respect to the crank angle for diesel and its B-20 Jatropha blend. Experimental data supports the simulation results. B-20 Jatropha blend possesses similar characteristics of diesel and serves as an alternative to diesel.
Risk Factor Associated Severity Disease and Hospitalized in COVID-19 Patients
Authors: Susanto Lisa Anggriani , Asina Girsang Dogi Gokma 
Published: February 2022

Background: In December 2019, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred in Wuhan City of Hubei Province of China, a worldwide pandemic. To describe clinical characteristics and length of stay of COVID-19 patients.
Methodology: This was observational analytic using medical record data. Study participants were adults (age ³ 18 years) with a positive results on real-time reverse transcription polymerase chain reaction (RT-PCR) for the presence of SARS-CoV-2. All confirmed cases of COVID-19 at Naibonat Regional General Hospital in East Nusa Tenggara, Indonesia between 2020 June and 2021 May were included the analysis. We excluded COVID-19 patients death were still hospitalized.
Results: In this study, a total of 38 participants are analyzed. we found that significant association statistically of length of stay patients (p value <0.05) are age (p=0.003), cough symptom (p=0.017).
Conclusion: In Conclusion, this study has shown that age and cough associated with length of stay.
Purification and Characterization of Thermostable Alkaline Xylanase by Aspergillus terreus from Elephant Dung
Authors: Nenava Richa , Nighojkar Sadhana , Patidar Mukesh , Kumar Anil , Nighojkar Anand 
Published: February 2022

Aims: Purification and characterization of xylanase by Aspergillus terreus isolated from elephant dung.
Study Design: Xylanase enzyme produced by A. terreus was extracted from the fermented solid medium using solid state fermentation and purified using chromatographic techniques. The purified enzyme was characterized for physio-chemical and kinetic properties.
Place and Duration of Study: Experiments were performed at the School of Biotechnology, Devi Ahilya University, Indore, INDIA and Maharaja Ranjit Singh College of Professional Sciences, Indore, INDIA, between June, 2019 and September, 2021.
Methodology: The enzyme was extracted and purified using ammonium sulphate precipitation, ion exchange chromatography using DEAE cellulose and gel filtration chromatography (GFC) using Sephadex G-200. The molecular weight of the purified enzyme was determined using native poly acrylamide gel electrophoresis (Native PAGE) and sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). The purified enzyme was characterized to determine pH and temperature optima. Thermostability, pH stability and substrate kinetics were studied for purified xylanase. Effect of several metal ions and detergents were also studied.
Results: The alkali-thermo xylanase of Aspergillus terreus was purified to 14.6-fold with a 39.48% recovery through IEC on DEAE-cellulose and GFC using Sephadex G-200. The purified enzyme had a specific activity, 111.6 U/mg. The SDS-PAGE revealed that the enzyme was monomeric with a molecular weight of 87 kDa. The optimum pH and temperature were 8 and 60⁰C, respectively. The Km and Vmax values of the partially purified xylanase were found to be 0.016 mg/l and 102.64 U/mg protein, respectively with birch wood xylan as substrate.
Conclusion: The enzyme was active over a wide pH range of 6-11 and temperature range of 40⁰C to 80ºC, indicating its alkali tolerant and thermostable characteristics which is the requirement of different industries. Several ions namely Zn2+ enhanced xylanase activity by 187% followed by Ca2+ (129%), Mg2+ (123%), NH4+ (146%) and Fe3+ (118%) at 10 mM concentration. However, Cu2+ and Hg2+ completely inhibited xylanase activity. This research provides the basis for application of xylanase and improves its biotechnological potential in mainly in paper pulp industry, biofuel generation and in bread baking.
Renoprotective Effect of Losartan Versus Enalapril in Children with Chronic Kidney Disease
Authors: El-Morsey Atyia Dina Hesham Aly , Shams Addein Shahinaz Mahmood , El Rifaey Shymaa Mohamed , Abd Elnabi Hend Hassan 
Published: February 2022

Background: Proteinuria is a marker of severity of chronic kidney disease)CKD) and leads to progression to end stage renal disease which can be reduced by blocking renin angiotensin aldosterone system(RAAS) through angiotensin converting enzyme inhibitors(ACEis) (e.g . enalapril) and angiotensin receptor blockers (ARBs) (e.g. losartan(
Aim of the Work: To evaluate the renoprotective effect of losartan versus enalapril in children with CKD.
Patients and Methods: This prospective cohort study was conducted on Sixty CKD children aged (5 to 17 years), were subdivided into three groups as the following: group I; 20 patients received enalapril, group II; 20 patients received losartan, group III; 20 patients didn’t receive losartan nor enalapril. All patients were subjected to thorough history, clinical evaluation and laboratory investigations (blood urea, serum creatinine, GFR, 24hours urinary proteins, serum albumin, lipid profile and serum electrolytes) initially and after 6monthes of treatment.
Results: this prospective cohort study was conducted on 34males and 26 females CKD children. Steroid dependantnephrotic syndrome (SDNS) was the commonest cause (53.3%)followed by diabetic nephropathy (DN)(15%), lupus nephritis(LN) (12%) and only 1 case was frequent relapse NS (FRNS). protienuria improved with 76.7% reduction in losartan group versus 45.6%reduction in enalapril group after 6 months of treatment. GFR increased by( 4.5%,8.6%) in losartan and enalapril groups respectively. Serum creatinine decreased by(11.6% and 8.3%) in losartan and enalapril groups respectively.
Conclusions: losartan and enalapril have a role in controlling proteinuria distinct from their antihypertensive effect .
A Study Protocol to Assess the Correlation of Endometrial Morphology with Concerned Hormone Levels in Patients of Abnormal Uterine Bleeding
Authors: Bhardwaj Tanvi , Hiwale Kishor , Vagha Sunita 
Published: February 2022

Background: Abnormal-uterine-bleeding (AUB) is caused due to numerous systemic or functional etiologies. Patients may come with metrorrhagia, menorrhagia, intermenstrual bleeding and polymenorrhea. The underlying pathology can be ascertained by histological variations of endometrium considering the age, the phase of menstrual cycle and the use of any exogenous hormones. This study aims to assess the correlation between endometrial changes and concerned hormone levels.
Methodology: This will be a Prospective study conducted for two years in Histopathology Department of Pathology, JNMC, Wardha. Total 65 female patients with complaint of irregular uterine bleeding will be included in this study. The histomorphology patterns of endometrial lesions will be studied and classified according to WHO classification. The collected data will be analysed using appropriate statistical methods.
Results: A Significant correlation is expected between endometrial changes and concerned hormone levels.
Conclusion: Conclusion will be drawn from the results obtained from the study.
A Study of Bcl-2 Immuno-expression in Invasive Ductal Carcinoma of Breast and it’s Correlation with Molecular Sub-types
Authors: Pandey Poornima , Bhake Arvind , Vagha Sunita 
Published: February 2022

Background: The incidence of Breast cancers has overtaken the cervical cancers amongst Indian females. Invasive Ductal carcinoma is reported to be the most common form of breast cancer. Bcl-2 has been studied extensively as a common factor in the pathogenesis of solid tumours including breast cancer. Bcl-2 is an anti-apoptotic protein normally expressed in mammary tissue and is up-regulated by oestrogen in breast cancer through direct consequence of transcriptional induction. The present study attempts to look into Bcl-2 immunoexpression as a key parameter for predicting the treatment outcomes and recurrence of Invasive Ductal Carcinoma.
Methodology : This will be an observational study conducted in Department of Pathology, JNMC, Wardha. The study will include clinicopathological detailing of 50 mastectomy specimens of Invasive ductal carcinoma, detailed sectioning of tumour tissues, histopathological BR-grading and molecular subtyping using Bcl-2 immunohistochemistry.
Expected Results: A significant correlation is expected between Bcl-2 expression and treatment outcomes and recurrence of Invasive Ductal Carcinoma.
Conclusion: The conclusion will be drawn based on careful analysis of the results.
Frequency of Bile Duct Injury during Laparascopic Cholecystectomy Procedures
Authors: Mangi Munawar Hussain , Paras . , Rahim Seema , Bashir Rubina , Khaskheli Ameer Ali 
Published: February 2022

Objective: To determine the frequency of bile duct injury during laparascopic cholecystectomy procedures.
Study Design: This is an observational study.
Setting: Study carried out at General Surgery department, Shaheed Benazir Bhutto Medical College, Lyari Karachi, from July 2019 to August 2021.
Materials and Methods: All diagnosed patients of gallstones on the clinically and findings of ultrasound of abdomen with age (20-60 years), gender were included in study. Patient not willing for surgery, pregnant ladies, bleeding disorders, obstructive jaundice and carcinoma of gall bladder were excluded from this study.
Results: Out of 162 patients, there were 15 males (9.25%) and 147 females (90.74%), with a male to female ratio of 1:11.6. The mean age was 36.01±8.11years (20 to 60 years). According to our observation, there were 6 cases (3.70%) of common bile duct injury during the operation. Treatments offered range from ERCP and conservative treatment to reconstructive surgery. Four patients (2.46%) were converted to open cholecystectomy, 1 patient underwent open cholecystectomy subsequent ERCP, and 1 patient underwent open Cholecystectomy with Subsequent Reconstructive surgery.
Conclusion: In our study bile duct injury commonly occur during laparoscopic cholecystectomy. Over time, improving surgical technique and experience reduced the overall incidence of CBD injuries.
Effectiveness of Knotless Barbed Sutures for Intraoral Closure after Impacted Mandibular Third Molar Surgery: A Split Mouth Randomized Clinical Trial
Authors: Krishnan Sneha , Periasamy Senthilnathan , Kumar M. P. Santhosh 
Published: February 2022

Objectives: The purpose of this clinical trial is to assess the efficiency of 3-0 knotless barbed suture (polydioxanone) with 4-0 polyglactin 910 (vicryl) in wound closure following impacted mandibular third molar surgery.
Methods: The split-mouth study involved 20 patients who were referred to the Oral Surgery Clinic at the Department of Oral and Maxillofacial Surgery for bilateral mandibular third molar impaction with equal difficulty index. Simple randomization was used to distribute the samples. Following extraction, the wounds were closed with 3-0 knotless sutures for the study group and 4-0 polyglactin 910 (vicryl) for the control group. Following surgical extraction in relation to infected mandibular molars under local anesthesia, the clinical outcome parameters that were measured were (1) time taken to achieve wound closure and hemostasis, and (2) post-operative wound healing using "Landry's wound healing index" on the 1st, 3rd, and 7th post-operative days.
Results: In this study, we discovered that the average time taken to approximate a wound was 2.69 minutes for the study group and 4.27 minutes for the control group. The research and control groups had a statistically significant difference in suturing time (p-value< 0.05). On all postoperative review days, wound healing in the study group was shown to be better and statistically significant than in the control group (p-value <0.05).
Conclusion: Within the limitations of the present study, knotless barbed suture is a promising alternative to conventional sutures for intra-oral wound closure as it reduces suturing time and facilitates effective wound closure following surgical removal of impacted mandibular third molars.
Simultaneous Estimation of Bilastine and Montelukast in Bulk by Rp-hplc and Assessment of Its Applicability in Marketed Tablet Dosage Form
Authors: Andhale Swati M. , Nikalje Anna Pratima G. 
Published: February 2022

Aim: This study proposes to develop and validate the RP-HPLC method for Bilastine and Montelukast and to substantiate the RP-HPLC analysis bestowing to ICH validation guideline Q2R1.
Place and Duration of Study: Y. B. Chavan College of Pharmacy, Aurangabad, MS, India, between January 2020 and October 2021.
Methodology: The mixture of drugs was subjected to optimization by trial runs with different chromatographic parameters, viz. flow rate, λ in nm, etc. The system suitability was performed by repeated injections of Bilastine (200µg/mL) and Montelukast (200µg/mL) to confirm the optimization. Furthermore, the demonstrated method was validated as per ICH Q2R1 recommendations for parameters like accuracy, precision, robustness, the limit of detection and quantitation, etc.
Results: The outcomes of the method in terms of percent relative standard deviation (%RSD) of retention time (RT) and mean peak area were seen as 0.09, 0.35, and 0.35, 0.56 for Bilastine and Montelukast, respectively. The method was successful in achieving the qualifying criteria entrusted to ICH guidelines. The correlation coefficient, slope, and y-intercept were illustrated to be 0.9971, 17595, 217883, 0.998, 35458, and 17147, correspondingly for Bilastine and Montelukast, respectively. The range was seen in the order of 160-260µg/mL and 80-130µg/mL for Bilastine and Montelukast. The precision of the method was established with %RSD of repeatability and intermediate precision was < 2 at three standard levels across the range. The %accuracy of the method was observed in the range of 96.95-101.41 %w/w and 97.37-101.89 %w/w in the order for Bilastine and Montelukast. The robustness of the method displayed the results within the prescribed boundaries. The recovered amount of Bilastine and Montelukast by spike method was observed to be 96.37-98.88 %w/w and 96.11-100.06%w/w.
Conclusion: The author has accomplished the predefined goals by successful development and validation of the RP-HPLC method for the quantification of Bilastine and Montelukast as per ICH Q2R1 guidelines.
Statins for the Treatment of Liver Fibrosis in Chronic Hepatitis-C Patients
Authors: Abbassi Amina , Lohano Ashok Kumar , Jamali Anwar Ali , Mughul Farah , Shaikh Muhammad Khalid , Shaikh Muhammad Zain , Ahmer Arslan 
Published: February 2022

Background: Hepatitis C virus (HCV) is one of the most common causes of chronic liver disease and the leading indication for liver transplantation worldwide. Chronic hepatitis C (CHC) leads to cirrhosis and hepatocellular carcinoma (HCC). Statins have gained attention for their pleiotropic effects. There is mounting evidence that statins offer chemoprevention against many malignancies. The aim of this was to determine the efficacy of the statin for the treatment of liver fibrosis in chronic hepatitis C patients.
Methodology: A randomized control trial was conducted at Hepatitis Clinic, People Medical College Hospital, Nawabshah from August 20, 2020, to February 20, 2021. Non-probability, consecutive sampling was adapted. Patients with chronic hepatitis C infection and liver fibrosis were included. Group-A was administered statins in addition to antiviral treatment while Group-B was given anti-viral medications only. Stages of fibrosis were determined by shear wave elastography at the start of the study and after 6 months. All the data were entered and analyzed in Statistical Packages for Social Sciences (SPSS) v25.0.
Results: There were 73 patients in each group. Fibrosis progression occurred in 7(9.6%) patients in group-A and 23(31.5%) in group-A. The link between the efficacy of the treatment given with the group-A and group-B was significant with a p-value of 0.001.
Conclusion: Findings demonstrate a significant reduction in the risk of fibrosis progression among statin users with advanced chronic hepatitis C. These results support a possible role for statins in the prevention of liver disease progression.