bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Polypharmacy and Potentially Inappropriate Medications Use in Elderly Chinese Patients: A Systematic Review and Meta-Analysis
Authors: Tian Fangyuan , Chen Zhaoyan , Wu Jinhui 
Published: June 2022

Objectives: Polypharmacy and potentially inappropriate medication (PIM) use among elderly Chinese patients have not yet been investigated by systematic review and meta-analysis. The purposes of this study were to investigate the prevalence of polypharmacy and PIM use and the risk factors associated with PIM use in elderly Chinese patients.Methods: Databases including PubMed, EMBase, and Web of Science were searched to collect studies which used Chinese criteria, Beers criteria, or STOPP criteria to evaluate the PIM status of elderly Chinese patients from inception to August 2021 (PROSPERO Code No: CRD42021262821). Observational studies reporting the prevalence of polypharmacy and PIM use in elderly Chinese patients were meta-analyzed. The pooled prevalence and risk ratio (RR) were calculated with a 95% confidence interval (CI).Results: A total of 8 articles involving 4,558,786 patients were included. The overall prevalence of polypharmacy (concomitant use of more than 5 medicines) and PIM use pooled by meta-analysis in Chinese older patients was 48% (95% CI: 0.17, 0.79, p = 0.003) (inpatients 73%, outpatients 23%) and 39% (95% CI: 0.25, 0.54, p &lt; 0.001) (inpatients 50%, outpatients 29%), respectively. Polypharmacy (RR: 2.03, 95% CI: 1.13, 3.64) was significantly associated with PIM use.Conclusion: This meta-analysis demonstrated a high prevalence of polypharmacy and PIM use among elderly patients in China. Affected by the quantity and quality of the included studies, the aforementioned conclusions need to be confirmed by large samples and high-quality studies.
Pipersentan: A De Novo Synthetic Endothelin Receptor Antagonist that Inhibits Monocrotaline- and Hypoxia-Induced Pulmonary Hypertension
Authors: Zhang Zeyu , Liu Chunlei , Bai Yongyi , Li Xin , Gao Xiaojian , Li Chen , Guo Ge , Chen Si , Sun Mingzhuang , Liu Kang , Li Yang , He Kunlun 
Published: June 2022

Background: Although major advances have been made in the pathogenesis and management of pulmonary arterial hypertension (PAH), the endothelin system is still considered to play a vital role in the pathology of PAH due to its vasoconstrictive action. Endothelin receptor antagonists (ERAs), either as monotherapy or in combination with other drugs, have attracted much attention in the treatment of this lethal disease, and research is continuing.Methods: A novel ERA, pipersentan 5-(1,3-Benzodioxol-5-yl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(2-methoxyethylsulfamoyl)pyrimidin-4-amine, was recently synthesized and the physicochemical characterizations and the pharmacology both in vitro and in vivo were studied.Results: This orally administered ERA can both competitively and selectively inhibit the binding of endothelin-1 (ET-1) to its receptors with good physicochemical characteristics. Pipersentan efficaciously antagonized the effects of ET-1 on pulmonary artery smooth muscle cell proliferation, migration and calcium mobilization and effectively improved right ventricular hypertrophy and pulmonary arterial pressure in both monocrotaline- and hypoxia-induced pulmonary hypertension (PH) rat models.Conclusions: This profile identifies pipersentan as a new agent for treating ET-1 system activation-related PH.
Understanding the Prooxidant Action of Plant Polyphenols in the Cellular Microenvironment of Malignant Cells: Role of Copper and Therapeutic Implications
Authors: Farhan Mohd , Rizvi Asim 
Published: June 2022

Plant derived polyphenolic compounds are considered critical components of human nutrition and have shown chemotherapeutic effects against a number of malignancies. Several studies have confirmed the ability of polyphenols to induce apoptosis and regression of tumours in animal models. However, the mechanism through which polyphenols modulate their malignant cell selective anticancer effects has not been clearly established. While it is believed that the antioxidant properties of these molecules may contribute to lowering the risk of cancer induction by causing oxidative damage to DNA, it could not be held responsible for chemotherapeutic properties and apoptosis induction. It is a well known fact that cellular copper increases within the malignant cell and in serum of patients harboring malignancies. This phenomenon is independent of the cellular origin of malignancies. Based on our own observations and those of others; over the last 30 years our laboratory has shown that cellular copper reacts with plant derived polyphenolic compounds, by a Fenton like reaction, which generates reactive oxygen species and leads to genomic DNA damage. This damage then causes an apoptosis like cell death of malignant cells, while sparing normal cells. This communication reviews our work in this area and lays the basis for understanding how plant derived polyphenols can behave as prooxidants (and not antioxidants) within the microenvironment of a malignancy (elevated copper levels) and gives rationale for their preferential cytotoxicity towards malignant cells.
Social Support and Coping Style of Medical Residents in China: The Mediating Role of Psychological Resilience
Authors: Xu Chao , Wang Yongyi , Wang Zongqin , Li Biao , Yan Chuandong , Zhang Sheng , Chen Bei , Zhang Di , Peng Juan 
Published: June 2022

ObjectivesRecent surveys have paid insufficient attention to the psychological status of medical residents, but medical residents, as a special group of medical workers, need to be focused on. This study aimed to investigate medical residents' levels of social support, psychological resilience, and coping style, and explore the mediating role of psychological resilience, which can ultimately provide a new theoretical basis for improving medical residents' psychological status and quality of work and life.MethodsA total of 577 medical residents from China were investigated by an online questionnaire, using convenience sampling. Associations between social support, psychological resilience, and coping styles were assessed using Pearson correlation analysis. The mediating effect of psychological resilience was tested using SPSS Process.ResultsPositive correlations between social support, psychological resilience and coping style were found (r = 0.474, P &lt; 0.001; r = 0.473, P &lt; 0.001; r = 0.353, P &lt; 0.001). The mediating effect of psychological resilience in the relationship between social support and coping style was significant (95% CI: 0.168, 0.384), and accounted for 25.84%.ConclusionAttention should be paid to the psychological status of medical residents, and social support and psychological flexibility can be used to increase the enthusiasm for their coping style and promote their mental health.
Perceived Family Function and Associated Predictors in Nurses: A Cross-Sectional Study
Authors: Zeng Wen , Fang Qian , Wang Cui , Tong Beibei , Li Dan , Zou Ziqiu , Liu Peiyuan , Yao Yuanrong , Shang Shaomei 
Published: June 2022

BackgroundNurses play a key role in the health care system. However, clinical nurses experience different kinds of stressors that might impact the nurses' quality of life or quality of care. Family is one of the main social support resources, and quality family function might improve the quality of care provided by nurses. However, evidence on family function in Chinese clinical nurses is quite limited.ObjectivesThe current study was to evaluate the family function of the Chinese clinical nurses, and to explore associated predicting factors.MethodsA multi-center cross-sectional anonymous online survey was carried out. Chinese Family Function Scale was used in the study. Spearman's rank correlation analysis, Mann-Whitney U test, or Kruskal-Wallis H test was performed in the univariate analysis. The pairwise comparison method was used to determine whether the difference was significant between pair groups. Categorical regression (optimal scaling regression) was the main method to analyze factors that had been confirmed to be statistically significant in the univariate analysis.ResultsNineteen thousand four hundred and twenty-two nurses completed the online questionnaires. The median of the nurse's perceived family function score was three (Inter-quartile Range: IQR 2–5). The multivariate analysis showed that the highest education level (P &lt;0.001), the hospital level (P &lt;0 .001), rotation shift status (P &lt;0.001), working department (P &lt; 0.001), number of children (P &lt; 0.001), monthly income per family member (P &lt; 0.001) were significantly associated with family function. Moreover, the importance of the factors was the number of children (49.1%), monthly income per family member (20.7%), rotation shift status (12.4%), the highest education level (8.0%), the hospital level (7.6%), and working department (2.4%) in turn.ConclusionsThe family function was associated with multiple factors, which hints that managers, leaders, and government could make strategies to improve nurses' family function in order to lead nurses to make a balance between family and work. Policymakers, nursing managers, and employers should make strategies such as promoting children-care services, increasing nurses' income, educating and training enough nurses, and building a well-established system of career development to help clinical nurses improve their family function so that to improve the quality of care.
Chronic Noise Exposure and Risk of Dementia: A Systematic Review and Dose-Response Meta-Analysis
Authors: Meng Linghao , Zhang Yang , Zhang Shushan , Jiang Fugui , Sha Leihao , Lan Yajia , Huang Lei 
Published: June 2022

ObjectiveEvidence is scarce about the effect of noise exposure on the risk of dementia. We conducted a systematic review and dose-response meta-analysis, aiming to explore the association between noise exposure and the risk of dementia.MethodsWe searched PubMed, EMBASE and the Cochrane Library to collect studies on chronic noise exposure and the risk of dementia from database inception to September 18, 2021 without language limitations. Two authors independently screened the literature, extracted data and assessed the risk of bias of the included studies. A dose-response meta-analysis and subgroup analysis were then conducted to detect the association between noise exposure and the risk of dementia by using Stata 14.0 software. This study is registered on PROSPERO (CRD42021249243).ResultsA total of 11 studies were eligible for qualitative synthesis, and nine were eligible for quantitative data synthesis. All of them showed moderate to high quality scores in the assessment of risk of bias. We found a positive linear association between the noise increment and dementia risk (R2 = 0.58). When noise exposure increased 57 dB, the RR of dementia was 1.47 (95% CI: 1.21–1.78). From the outcome subgroup of AD, AD and dementia, VaD and NAD, we also found a positive association (R2 = 0.68, 0.68, 0.58, respectively). When noise exposure increased by 25 dB, the RRs were 1.18 (95% CI: 1.14–1.23), 1.19 (95% CI: 1.14–1.23) and 1.17 (95% CI: 1.06–1.30), respectively. We found a nonlinear association between the noise increment and dementia risk when only cohort studies were included (R2 = 0.58). When noise exposure increased by 25 dB, the RR of dementia was 1.16 (95% CI: 1.12–1.20). From the subgroup of AD, AD and dementia, VaD and NAD of cohort studies, the regression curve showed a nonlinear positive association (R2 = 0.74, 0.71, 0.43, respectively). When noise exposure increased by 25 dB, the RRs were 1.17 (95% CI: 1.12–1.21), 1.17 (95% CI: 1.12–1.22) and 1.13 (95% CI: 0.99–1.28), respectively.ConclusionBased on the current evidence, exposure to noise may be a specific risk factor for dementia. To better prevent dementia, more rigorously designed studies are needed to explore the etiological mechanism of noise and dementia.
Knowledge Structure and Emerging Trends of Telerehabilitation in Recent 20 Years: A Bibliometric Analysis via CiteSpace
Authors: Zheng Jiaqi , Hou Meijin , Liu Lu , Wang Xiangbin 
Published: June 2022

PurposeTelerehabilitation, as an effective means of treatment, is not inferior to traditional rehabilitation, and solves the problem of many patients who do not have access to hospital-based training due to costs and distance. So far, the knowledge structure of the global use of telerehabilitation has not been formed. This study aimed to demonstrate the state of emerging trends and frontiers concerning the studies of telerehabilitation through bibliometric software.MethodsLiterature about telerehabilitation from 2000 to 2021 was retrieved from the Web of Science Core Collection. We used CiteSpace 5.8.R3 to analyze the publication years, journals/cited journals, countries, institutions, authors/cited authors, references, and keywords. Based on the analysis results, we plotted the co-citation map to more intuitively observe the research hotspots and knowledge structure.ResultsA total of 1,986 records were obtained. The number of annual publications gradually increased over the investigated period. The largest increase occurred between 2019 and 2020. J TELEMED TELECARE was the most prolific and the most cited journal. The United States was the most influential country, with the highest number of publications and centrality. The University of Queensland was the most productive institution. The author Tousignant M ranked the highest in the number of publications and Russell TG ranked the first in the cited authors. Respectively, the articles published by Cottrell MA and Russell TG ranked the first in the frequency and centrality of cited references. The four hot topics in telerehabilitation were “care”,“stroke”, “telemedicine” and “exercise”. The keyword “stroke” showed the strongest citation burst. The two frontier keywords were “physical therapy” and “participation”. The keywords were clustered to form 21 labels.ConclusionThis study uses visualization software CiteSpace to provide the current status and trends in clinical research of telerehabilitation over the past 20 years, which may help researchers identify new perspectives concerning potential collaborators and cooperative institutions, hot topics, and research frontiers in the research field. Bibliometric analysis of telerehabilitation supplements and improves the knowledge field of telemedicine from the concept of rehabilitation medicine and provides new insights into therapists during the COVID-19 pandemic.
Lost in fragmentation — care coordination when somatic symptoms persist: a qualitative study of patients’ experiences
Authors: Barends Hieke , Botman Femke , Walstock Ella , Dessel Nikki Claassen-van , van der Wouden Johannes C , olde Hartman Tim , Dekker Joost , van der Horst Henriëtte E 
Published: June 2022

BackgroundGPs can play a central role in the care of patients with persistent somatic symptoms (PSS). To date, little is known about these patients’ experiences relating to their coordination of care.AimTo explore the experiences of patients with PSS relating to coordination of care — in particular by their GP — during their illness trajectory.Design and settingThis qualitative study was carried out from January to April 2019 in the Netherlands as part of a multicentre prospective cohort study on the course of PSS (PROSPECTS).MethodThematic content analysis of 15 interviews.ResultsThree themes were identified: care fragmentation during the diagnostic trajectory; transition from the search for a cure to coping; and reframing to coping: GPs’ role in facilitating supportive care. Patients experienced a lack of collaboration from healthcare workers during the diagnostic trajectory. Guidance by their GP in a process of shared decision making was positively valued by patients. Moving the focus from searching for a cure to coping with symptoms was described as a ‘personal endeavour’, made even more challenging by the ongoing uncertainty experienced by patients. When reframing to coping, the extent to which patients felt aligned with their GP played an important role in whether their supportive care request was met.ConclusionPatients experienced difficulties when navigating the diagnostic trajectory and shifting to coping. The findings of this study underline the importance of collaboration between GPs and other healthcare professionals during the diagnostic trajectory. The authors recommend that GPs provide proactive guidance and are sensitive to patients who shift to coping by providing them with supportive care in a process of shared decision making.
Kronik Bel Ağrılı Hastalarda Obezitenin Fiziksel Performans Üzerine Etkisi
Authors: BAŞ Melek , BAŞKURT Zeliha , BAŞKURT Ferdi 
Published: June 2022

Giriş ve Amaç: Bu çalışmanın amacı kronik bel ağrılı hastalarda obezitenin fiziksel performans, özürlülük, yaşam kalitesi, ağrı, denge ve fonksiyonel mobilite üzerine etkisini saptamaktır.
Gereç ve Yöntemler: Çalışmaya 18-65 yaş arası 102 kişi dahil edilmiştir. Olgular; Vücut Kütle İndeksine (VKİ) göre üç gruba ayrılmıştır (normal kilolu (grup I), fazla kilolu (grup II), obez (grupIII)). Tüm hastalara Fiziksel Performans Test Bataryası (FPTB), Oswestry Özürlülük Ölçeği (OÖÖ), Kısa Form- 36 (KF-36), Görsel Analog Skalası (GAS) ve Süreli Kalk Yürü Testi uygulanmıştır.
Bulgular: FPTB parametrelerinden 5 dk yürüme ve ağırlıkla öne uzanma parametrelerinde grup III ile grup I arasında anlamlı fark tespit edilmiştir (p0.05). OÖÖ verilerinde ve KF-36’nın 8 alt parametresinde her üç grup arasında fark tespit edilmemiştir (p>0.05). Ancak VKİ ile KF-36’nın fiziksel fonksiyon parametresi arasında negatif korelasyon bulunmuştur (r=-,231; p
Compliance and feedback of hydroxychloroquine treatments in home follow-up patients with diagnosis of COVID-19
Authors: ESEN Ayşe Didem , GUNHER ARICA Seçil , ŞİMŞEK Funda 
Published: June 2022

Objective: In this study we aimed to evaluate the medication compliance and feedback of the patients who were registered in Education Family Health Centers (EASM) and who received hydroxychloroquine (HCQ) treatment at home due to COVID-19.
Materials and Methods: Patients who were being treated at home and being treated for hydroxychloroquine due to COVID-19 registered in Education Family Health Centers affiliated to our hospital were included. These patients who were followed at home were contacted once between the 6th and 14th days of home follow-up. The patients were asked questionnaire questions including 31 items including information on their compliance with hydroxychloroquine treatment, drug side effects, feedback, duration of symptoms such as fever and cough, re-referrals to the hospital. The data collected through questionnaires were evaluated by statistical analysis.
Results: Statistical analysis was done with SPSS version 17.0 program. A total of 67 patients, 37 men and 30 women, participated in the study. The average age is 45.34 ± 19.01 years. There are 7 patients with moderate symptoms and 60 people who have mild symptoms. One patient had skin rush and stopped the treatment because of adverse effect. 63 patients had a reduction in their symptoms. There were 23 patients hospitalized and the average duration is 12.96 ± 5.92 days. There were 5 patients who are referred to the hospital again. Among patients 33 were receiving azithromycin combined with HCQ and their re-hospitalization rates were lower.
Conclusion: HCQ was observed efficient in relieving the COVİD-19 symptoms in most of the home follow-up patients Azithromycin combined with HCQ reduced re-hospitalization rates.
Covid-19 Tutulumu Toparlanma Sonrası Hangi Vücut Sistemlerinde Rehabilitasyon Gerektirecek? Tanımlayıcı Derleme
Authors: YILDIRIM Yasin , YURDALAN Ufuk 
Published: June 2022

Giriş ve Amaç: 2019 yılı sonunda Çin’in Hubei eyaletindeki Wuhan şehrinde eş zamanlı olarak 54 viral pnömoni vakası görülmüş, ve yapılan araştırmalar sonucunda Coronaviridae ailesine ait yeni bir koronavirüs olan COVID-19 tanımlanmıştır. 11 Mart 2020’de Dünya Sağlık Örgütü tarafından pandemi olarak ilan edilmiştir. COVID-19'un temel semptomları ateş, öksürük ve miyaljidir. Diğer küçük semptomlar boğaz ağrısı, baş ağrısı, titreme, mide bulantısı veya kusma, ishal, tat duyusunun kaybolması ve konjunktival tıkanıklıktır. Özellikle pulmoner sistem etkilenmektedir. Pulmoner rehabilitasyonun akut tedavi aşamasında kullanılması gerektiği ile ilgili çalışmalar bulunmaktadır. Ancak virüsün pulmoner sistem dışındaki bulgularına ve uzun dönem bulgularına odaklanan çok sayıda çalışma bulunmamaktadır. Çalışmamızın amacı; COVID-19 sonrası hangi vücut sistemlerinin etkilendiğinin, kronik bulgularının ve hangilerinin rehabilitasyon kapsamına gireceğinin belirlenmesidir.
Gereç ve Yöntemler: İlgili yayınları belirlemek için PubMed, Web of Science, Scopus ve PEDro'da sistematik bir literatür taraması yapıldı. Veritabanı taramasına dahil olmak için yayınların İngilizce veya Türkçe yazılmış olması gerekiyordu. Anahtar terim olarak 'COVID-19', 'Post-COVID Sendromu' ve 'Uzun-COVID' anahtar terimleri ve ayrıca 'klinik semptomlar', 'pulmoner semptomlar', 'kardiyovasküler semptomlar', ‘nörolojik semptomlar’ ve ‘kognitif semptomlar’ ile ilgili farklı arama terimleri varyasyonları yer aldı.
Bulgular: Pandeminin uzun dönem sonuçlarında birçok vücut yapısının etkileneceği gösterilmiştir. Etkilenen bu sistemlerin rehabilitasyon kapsamına gireceğini düşünmekteyiz. Ancak kronik semptomlara ve hasarlanan vücut sistemlerine odaklanan çalışma sayısının çok yetersiz olması kesin semptomların belirlenmesini güçleştirmektedir. Sonuç: Semptomların tam olarak belirlenebilmesi için virüsün uzun dönem etkilerine odaklanan daha çok çalışmaya ihtiyaç vardır.
El Marco Jurídico de la política exterior de México
Authors: Félix Jaramillo Karla Verónica 
Published: June 2022

Este libro comprende un estudio del marco jurídico de la Política Exterior mexicana desde la comprensión integral de la misma, en el que se visibiliza el análisis de los fundamentos legales que rigen la teoría y práctica de esta disciplina donde se reúne a 26 especialistas del Derecho, Economía y Relaciones Internacionales. Esta obra se conforma por 241 páginas en las que se analizan las dinámicas de los actores involucrados y las diversas legislaciones en cuestión. Para ello, se consideran como punto de partida las bases legales de la política exterior mexicana y su relación con las esferas del ámbito político, económico y social.
Solo Fértil: Promovendo ações de conscientização sobre segurança alimentar no Campus Campo Grande do IFMS
Authors: Amorim da Rocha Flavio , Barbosa da Silva Cavalcante Letícia , Rodrigues Aniceto Teixeira Vitória , Fejes dos Santos Tabosa Silvia Helena 
Published: June 2022

Este relato de experiência objetiva apresentar ações que vêm sendo implementadas a fim de minimizar impactos gerados pela Insegurança Alimentar no âmbito do Campus Campo Grande do Instituto Federal de Mato Grosso do Sul por meio do Projeto Solo Fértil. A pesquisa, de caráter multicampi, em parceria com a Universidade de Illinois, nos Estados Unidos, prevê o levantamento do perfil alimentar dos estudantes da instituição. A partir de discussões realizadas entre as partes envolvidas, foi possível desenvolver uma visão ampla acerca da problemática e delimitar, segundo as necessidades levantadas junto à comunidade escolar, estratégias de atuação. Além da promoção do letramento crítico alinhado ao ensino da língua inglesa, o projeto, em ação conjunta com o Núcleo de Voluntariado Educativo (NuVE), possibilitou a criação de três frentes de trabalho: a confecção e distribuição de papel semente, a construção de uma horta vertical dentro do Campus e o perfil do projeto no Instagram, que tem por objetivo a divulgação das ações desenvolvidas e de dicas para uma alimentação mais saudável, em consonância com os estudos realizados sobre Segurança Alimentar. Destaca se, ainda, o protagonismo dos estudantes frente à condução do projeto, reforçando o papel da escola na formação holística do sujeito.