bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the effect of intermittent microwave drying conditions on the bioactive compounds and antioxidant capacity of beetroots
Authors: Liu Yan , Duan Zhenhua , Sabadash Sergey , Shang Feifei 
Published: March 2022

The object of this research was the beetroots prepared by intermittent microwave drying at different conditions. The paper aimed to investigate the influence of intermittent microwave drying conditions (power density, microwave gap ratio and slice thickness) on the bioactive compounds and antioxidant capacity of beetroots. A microwave drying system SAM-255 (CEM Corporation, USA) was used to intermittent microwave drying of fresh beetroots. The effect of different power densities (1.0, 1.5, 2.0, and 2.5 W/g), microwave gap ratios (1, 2, 3, and 4) and slice thicknesses (2, 4, 6, and 8 mm) on the bioactive compounds and antioxidant capacity of beetroots were investigated. Colorimetric methods were used to determine contents of betalains, total phenolic and total flavonoid, and antioxidant capacity of dried beetroots. The ascorbic acid content was determined using 2,6-dichloroindophenol titration method.
Results showed that power density, microwave gap ratio and slice thickness significantly affected the drying time, bioactive compounds and antioxidant capacity of beetroots. The drying time decreased with the increasing of power density, while increased significantly with the growth of slice thickness and microwave gap ratio. The shortest drying time (35.4±2.6 min) of beetroots was occurred at microwave gap ratio of 2. The content of betacyanins was found to be the highest in the dried beetroots with thickness of 2 mm. The beetroots with slice thickness of 2 and 4 mm showed the highest betacyanins content. Moreover, the highest content of ascorbic acid (240.00±2.32 mg/100 g) and total flavonoid (14.52±0.06 mg rutin equivalent (RE)/g) was appeared at power density of 2.0 W/g, while the content of total phenolic to be highest (12.54±0.13 mg gallic acid equivalent (GAE)/g) at slice thickness of 6 mm. For the antioxidant capacity of dried beetroots, the 1,1-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity reached to the highest value of 6.43±0.03 mg trolox equivalent (TE)/g at power density of 2.5 W/g. While the highest values of ferric-reducing antioxidant power (FRAP) (15.47±0.10 mg TE/g) and 2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging activity (25.31±0.30 mg TE/g) at microwave gap ratio of 2. It was found that ABTS radical scavenging ability and FRAP were related to the presence of reductions including betalains, ascorbic acid, and total flavonoid in beetroots.
The most effective condition for intermittent microwave drying of beetroots were microwave gap ratio of 2, power density of 2.0 W/g, and slice thickness of 4 mm, leads to a better preservation of bioactive compounds and high antioxidant capacity.
Forming of properties complex of copper wire by the method of combined deformation by torsion and tension
Authors: Pashynska Olena , Pashynskyi Volodymyr , Kraliuk Maryna , Boyko Igor 
Published: March 2022

The object of research is the mechanical properties of copper wire M1 for electrical applications, subjected to combined torsional deformation with tensile tension. One of the most problematic aspects in the manufacturing of such a wire is its fracture during processing due to low strength and ductility. DSTU EN 13602:2010 regulates the ultimate tensile strength, relative elongation, the number of bends before fracture and the number of twists until failure. To increase the service life of the product it is necessary to increase strength and plastic properties.
The methods of influence on the material by combined plastic tensile deformation with tensile was used in the study, the mechanical characteristics (ultimate tensile strength, true deformation before failure, relative elongation, relative reduction in area) and electrical conductivity were determined. Statistical analysis tools were used for modeling and graphical displaying of data.
The proposed approach allows to select the modes of combined torsional deformation with tensile, providing the optimal combination of tensile strength and relative narrowing of M1 grade copper wire. Under certain modes of such deformation, with increasing degree of deformation, it is possible to increase the strength characteristics and at the same time obtain high values of plasticity.
The obtained results of approbation of different combined deformation modes allow to consider it an effective tool for achieving high values of true rapture stress and ultimate deformation in order to improve the service characteristics of the deformed wire. It is shown that relaxation processes occur during such treatment, which leads to a decrease in stresses and a sharp increase in plastic characteristics. Clarification of the mechanisms of the characteristics formation allows to control the features of the structure and, accordingly, the level of mechanical properties to obtain a wire that combines high strength with high toughness. This makes it possible to develop deformation modes to obtain copper wire with special properties depending on customer requirements, for example: strong wire with low electrical resistance.
Rare Case of Morquio Syndrome (Mucopolysaccharidosis Type IVA): Difficulties of Diagnostic Search and Management
Authors: Semschikova Yulia P. , Kozlov Yurii A. , Yakovlev Andrei B. , Shinkareva Vera M. , Barzunova Tatyana V. , Manjkova Natalia I. , Balakirev Evgenii A. 
Published: March 2022

Background. This clinical case is of practical interest due to the lack of epidemiological and clinical data in Russian Federation and worldwide, difficulties in diagnosis at the disease onset, as well as little experience in enzyme replacement therapy for mucopolysaccharidosis type IVA (MPS IVA).Clinical case description. MPS IV (Morquio syndrome) diagnosis at the age of 11 was based on typical progressive external signs such as thoracolumbar scoliosis, coxarthrosis with restriction of both active and passive movements. Enzymodiagnostics in dried blood spots has shown dramatic decrease of N-acetylgalactosamine-6-sulfatase activity — 0.01 μM/l/h specific to MPS IVA. Direct automatic sequencing of the GALNS gene has revealed pathogenic nucleotide variants in the compound heterozygous state: c.143T>G; p(Val48Gly) and c.697G>A; p.(Asp233Asn). That allowed us to establish MPS IVA diagnosis. Enzyme replacement therapy with elosulfase alpha was started according to the protocol. According to significant changes in the musculoskeletal system, the expected therapeutic effect (stabilization and no disease progression) can be achieved not earlier than after 8–12 months.Conclusion. Timely MPS diagnosis allows us to implement enzyme replacement therapy at the earliest possible time and thereby to avoid non-reversible complications of the disease itself.
α-Parvin Defines a Specific Integrin Adhesome to Maintain the Glomerular Filtration Barrier
Authors: Rogg Manuel , Maier Jasmin I. , Van Wymersch Clara , Helmstädter Martin , Sammarco Alena , Lindenmeyer Maja , Zareba Paulina , Montanez Eloi , Walz Gerd , Werner Martin , Endlich Nicole , Benzing Thomas , Huber Tobias B. , Schell Christoph 
Published: March 2022

Significance Statement
Although podocyte detachment is a well-established factor driving the progression of glomerular kidney diseases, the underlying mechanisms initiating podocyte loss remain elusive. In particular, the co-occurrence of podocyte detachment and adaptive reinforcement of the actin cytoskeleton and integrin adhesion complexes presents a conundrum. The authors provide a comprehensive map of the podocyte adhesome and identify an actin-binding adhesome protein, α-parvin (PARVA), as a podocyte-specific mechanical linker. By employing a complementary approach involving both in vivo and in vitro models, they demonstrate that PARVA prevents podocyte detachment via mechano-adaptive remodeling of adhesion complexes. These observations suggest that insufficient linkage of a tensile actin cytoskeleton to integrin adhesion complexes is a causative mechanism in podocyte detachment in glomerular diseases.

Background
The cell-matrix adhesion between podocytes and the glomerular basement membrane is essential for the integrity of the kidney’s filtration barrier. Despite increasing knowledge about the complexity of integrin adhesion complexes, an understanding of the regulation of these protein complexes in glomerular disease remains elusive.

Methods
We mapped the in vivo composition of the podocyte integrin adhesome. In addition, we analyzed conditional knockout mice targeting a gene (Parva) that encodes an actin-binding protein (α-parvin), and murine disease models. To evaluate podocytes in vivo, we used super-resolution microscopy, electron microscopy, multiplex immunofluorescence microscopy, and RNA sequencing. We performed functional analysis of CRISPR/Cas9-generated PARVA single knockout podocytes and PARVA and PARVB double knockout podocytes in three- and two-dimensional cultures using specific extracellular matrix ligands and micropatterns.

Results
We found that PARVA is essential to prevent podocyte foot process effacement, detachment from the glomerular basement membrane, and the development of FSGS. Through the use of in vitro and in vivo models, we identified an inherent PARVB-dependent compensatory module at podocyte integrin adhesion complexes, sustaining efficient mechanical linkage at the filtration barrier. Sequential genetic deletion of PARVA and PARVB induces a switch in structure and composition of integrin adhesion complexes. This redistribution of these complexes translates into a loss of the ventral actin cytoskeleton, decreased adhesion capacity, impaired mechanical resistance, and dysfunctional extracellular matrix assembly.

Conclusions
The findings reveal adaptive mechanisms of podocyte integrin adhesion complexes, providing a conceptual framework for therapeutic strategies to prevent podocyte detachment in glomerular disease.
DİYARBAKIR İLİ BİYOKÜTLE POTANSİYELİ VE ENERJİ ÜRETİMİ
Authors: YILDIRIM Ayşegül Mizgin , NACAR KOÇER Nilüfer 
Published: March 2022

Artan dünya nüfusu, azalan kaynaklar, global ölçekte yaşanan çevre sorunları, fosil yakıtların sınırlı ve tükenmeye yakın oluşu enerjinin orta ve uzun vadede ulaşılabilirliğinin azalacağinı göstermektedir. 2015 yılında Birleşmiş Milletler Kalkınma Programı kapsamında kabul edilen Sürdürülebilir Kalkınma Amaçları (“SKA”) kapsamındaki 2030 yılına kadar ulaşılması hedeflenen 17 amaçtan biri “Erişilebilir ve Temiz Enerji” kaynaklarıdır. Temiz enerjiye adil ve eşitlikli erişim, sürdürülebilir kalkınma ve doğa için, yenilenebilir enerji kaynaklarına yönelim bir ihtiyaç ve zorunluluktur. Yenilenebilir enerji kaynakları arasında biyokütle enerjisi önemli bir erişilebilir ve temiz enerji olanağı sunmaktadır.
Bu çalışmadadünya genelinden Diyarbakır İli özeline olacak bir kapsamla olası biyoenerji potansiyelinin neden değerlendirilmesi gerektiğine değinilmiş, biyokütle, biyokütle kaynakları ve biyoenerji çevrim teknolojileri tanımlanmış ve Diyarbakır İli ve ilçelerine ait 2019 ve 2020 yıllarındaki hayvansal ve tarım kaynaklı ortalama kuru biyokütle miktarı ve ısıl değeri hesaplanarak yorumlanmıştır.
Psychological symptoms and sexual satisfaction in polygamic and monogamic wives
Authors: YILMAZ Ertan 
Published: March 2022

Purpose: This study aimed to investigate the sexual satisfaction and mental health indicators in polygamous and monogamous women in Turkey. The study included 108 female participants: 36 monogamous wives and 72 polygamous wives.
Materials and Methods: The participants were evaluated with the Symptom Check List (SCL-90-R) and Golombok-Rust Inventory of Sexual Satisfaction (GRISS).
Results: There were significant differences between the groups regarding the total GRISS score and Dissatisfaction, Sensuality, Vaginismus, and Anorgasmia subscale scores. In comparing the SCL-90 scores with ANOVA, the senior wife group had significantly higher scores in the Depression subscales. Monogamic wives had higher satisfaction from their sexual lives and had less frequent psychiatric symptoms than polygamic wives.
Conclusion: It is important to raise awareness about the polygamic family structure, draw attention to often neglected issues such as sexual health, and improve the health services provided to this group.
Evaluation of lipid levels and LDL-C/HDL-C ratio as possible risk markers of intracerebral hemorrhage
Authors: ADIGÜZEL Ahmet , ÇIPLAK Sibel , ÖZTÜRK Ünal 
Published: March 2022

Purpose: The aim of this study is to analyze the utility of lipid parameters individually and the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio as a possible risk marker for intracerebral hemorrhages (ICH).
Materials and Methods: This was a multicenter, retrospective case-control study that included 226 patients with ICH and 226 controls. Lipid parameters were evaluated after 12 h of fasting in patients whose ICH was confirmed by brain computed tomography, and no underlying vascular, traumatic, or metabolic cause could be found.
Results: The mean LDL-C levels and mean total cholesterol (TC) levels did not differ in in the patient and control groups. The mean HDL-C levels in the patient groups were significantly lower whereas triglyceride (TG) levels were significantly higher. In the patient and control groups, LDL-C/HDL-C ratio was 2.65±1.10 and 2.94±1.13 (p=0.006), TG/HDL-C ratio was 3.60±2.72 and 4.47±3.25 (p=0.002), and TC/HDL-C ratio was 4.37±1.49 and 4.83 ± 1.56 (p=0.002), respectively.
Conclusion: Increased TG and decreased HDL-C levels were found to be associated with ICHs. However LDL-C/HDL-C, TC/HDL-C, and TG/HDL-C ratios were low in the patient group. Therefore, we can conclude that these lipid ratios give clearer and more significant results in determining the risk of hemorrhage.
A case of severe hypoglycemic encephalopathy
Authors: Balagopal Krishnan , Suku Sherin , Ebrahim Ameer 
Published: March 2022

Hypoglycemic encephalopathy is a metabolic encephalopathy that usually occurs in diabetic patients and is due to low levels of blood glucose in the body. The clinical presentation varies in severity from mild cases presenting with fatigue, sweating and poor concentration to severe cases leading to stupor, coma and death. Diagnosis is often delayed due to inadequate recognition of the cause and diverse clinical picture. Imaging studies show characteristic changes in the cerebral cortex and deep grey nuclei. Management is mainly supportive. We present here a case of a seventy five year old diabetic who was found lying unresponsive at home in the morning and was brought to the emergency. She was found to have very low levels of blood glucose which were corrected with no improvement in the sensorium. She was ventilated and treated with glucose infusions and supportive care. MRI scans of the brain showed features of extensive hypoglycemic encephalopathy with damage of the parietal and occipital cortices and also deep gray nuclei including thalami bilaterally. She had no change in clinical status after a prolonged hospital stay and succumbed to secondary infection. Prolonged hypoglycemia leads to widespread neuronal damage through energy failure and apoptosis. This leads to prolonged coma and even death in severe cases. This case report is meant to stress the importance of early diagnosis and treatment in the long term outcome of hypoglycemic encephalopathy.1. Hypoglycemic encephalopathy is an important clinical entity with a wide variety of clinical presentations; 2. We present here a case of a seventy five year old diabetic with a prolonged duration of hypoglycemia and severe hypoglycemic encephalopathy who had a poor outcome; 3. Early diagnosis and treatment are essential for good long term outcomes.
Formation of students’ communicative competence through game technology
Authors: Kargash Atymanova , Gulden Yespolova , Yerubay Baibekov , Akmara Berdaliyeva , Omarov Nurlybek , Nagashbek Zhilisbayev 
Published: March 2022

The aim of this study is to determine the creation of communicative competencies of students with game technology. The research was conducted in the fall semester of 2021–2022; the research consists of 327 volunteer students studying at universities in Kazakhstan and continuing their education. According to the sub-objectives of the research, the use of gamification technologies by university students during the day, the time spent by university students using the Internet and the situations were focused on. In the scope of the study, descriptive statistical methods were used for the development of students' communicative competencies with the gamification technology of university students. The research is a quantitative research method and is designed according to the analysis of students' views on the formation of communicative competencies on gamification technologies. According to the results of the research, it has been concluded that communicative skills increase with game technology. In addition, according to the results of the research, it was concluded that university students use the time zone on the Internet on the spot.

Keywords: University students, gamification, communicative competence;
The Effect of Drying Method on Potential Antioxidants in Ethanol Extract of Sungkai Leaf (Parenoma Canescens Jack.) Simplicia from Kalimantan
Authors: Wati Fahrina Kasuma , Hasnah Siti Hasnah - 
Published: March 2022

Sungkai (P. canescens) is a medicinal plant whose leaves are used to alleviate fever and strengthen the body's immune system. This study aimed to determine the effect of the simplicia drying technique on the antioxidant potential of the ethanol extract of Sungkai leaves from Kalimantan. The drying method employed was oven drying at 70°C, oven drying at 50°C, sun drying, and wind drying. The study's findings indicated that the antioxidant activity of all drying techniques was in the very active category. The drying method with the lowest antioxidant potential was oven drying at 50°C with IC50 value of 13.340 ppm, wind drying with IC50 value of 14.610 ppm, sun drying with IC50 value of 16.799ppm, and oven drying at 70°C with IC50 value of 17.034 ppm. Keywords: Sungkai leaf ; IC50; antioxidant
Omega-3 Polyunsaturated Fatty Acids: the Role in Prevention of Atrial Fibrillation in Patients with Coronary Artery Disease after Coronary Artery Bypass Graft Surgery
Authors: Rubanenko O. A. , Shchukin Yu. V. , Limareva L. V. , Ryazanova T. K. , Rubanenko A. O. , Davydkin I. L. 
Published: March 2022

Aim. To estimate the role of omega-3 polyunsaturated fatty acids (PUFAs) administration in atrial fibrillation (AF) prevention after planned coronary artery bypass graft (CABG) surgery.Material and Methods. Studied were 306 patients divided into two groups: patients of group I didn’t receive PUFAs (158 patients, 82.7% males) and patients of group II received PUFAs (148 patients, 89.3% males). PUFAs were prescribed in daily dose 2000 mg 5 days before surgery and in daily dose 1000 mg in postoperative period during 21 days.Results. Postoperative AF (POAF) occurred in 29.7% patients in group I and in 16.9% patients in group II (р=0.009). We found that after CABG in patients of the I group median IL-6 level was 39.3% higher (p=0.001), interleukin-10 – 20.2% higher (p=0.01), superoxide dismutase – 78.9% higher (р<0.001), malondialdehyde – 33.8% higher (p=0.03), docosahexaenoic acid – 31.8% lower (p=0.01) and omega-3 index – 43.4% lower (p=0.04) than in patients of the II group.According to multivariate regression analysis we found significant association between the factors of inflammation, oxidative stress and the risk POAF development.Conclusions. In patients who took PUFAs, we found less activation of inflammation, oxidative stress, the increasing of docosahexaenoic acid and omega-3 index accompanied by the decreasing of POAF development rates up to 12.8%.
Noncompact Myocardium with Dilated Phenotype: Manifestations, Treatment and Outcomes in Comparison with Other Forms of Dilated Cardiomyopathy Syndrome
Authors: Blagova O. V. , Pavlenko E. V. , Varionchik N. V. , Sedov V. P. , Gagarina N. V. , Mershina E. A. , Polyak M. E. , Zaklyazminskaya E. V. , Nedostup A. V. 
Published: March 2022

Aim. To study the place of NCM in the structure of DCM, its clinical features and influence on prognosis in comparison with other forms of DCM syndrome.Methods. The NCM registry includes 125 patients, mean age 46.4±15.1 years, 74 men and 51 women, median follow-up 14 [4.0; 41.0] months. The DCM registry included 365 patients, mean age 46.4±15.1 years, 253 men and 112 women, median follow-up 14 [5; 43.75] months. The examination included electrocardiography (ECG), ECG Holter monitoring, echocardiography, blood anti-heart antibody level evaluation, and additionally cardiac computed tomography, magnetic resonance imaging, DNA diagnostics (in the MYH7, MYBPC3, TPM1, TNNI3, TNNT2, ACTC1, TAZ, ZASP (LDB3), MYL2, MYL3, DES, LMNA, EMD, TTR gene panel), coronary angiography, right ventricular endomyocardial biopsy.Results. The proportion of patients with DCM phenotype in the NCM registry was 40% (n=49), another 11% (n=15) had NCM diagnosed simultaneously with acute/subacute myocarditis. Lethality in these subgroups was 12.2% and 33.3%, respectively, and was significantly higher than in asymptomatic, ischemic and arrhythmic variants of NCM. In the DCM registry, the proportion of patients with NСM was 21% (n=78), and increased left ventricular (LV) trabecularity was detected in another 18% (n=64). DCM patients with and without NСM did not differ by baseline echocardiographic parameters, heart failure class, and cardiotropic therapy. Pathogenic mutations were detected in 14% of DCM patients with NCM and only 3% of other patients with DCM (p<0.001). Only in patients without NCM the presence of mutations had a significant effect on lethality. The patients with NCM compared with the others DCM patients showed significantly lower increase in EF in early and late period (from 31.0±10.2 to 34.8±11.0 and 37.1±10.9% [р<0.05] vs from 31.8±9.7 to 38.8±11.3 and 42.3±12.4% [р<0.01] respectively), a greater incidence of premature ventricular beats (1568 [105;7000] vs 543.5 [77.75; 3194], p<0.05), appropriate defibrillator shocks and sudden deaths (17.9 vs 5.9%, p<0.001), intracardiac thrombosis (21.8 vs 13.5%, p=0.069) despite a greater frequency of anticoagulants (73.1 vs 57.4%, p<0<05). There were no significant differences in death (19.2 vs 18.5%) and transplantation (7.7 vs 3.8%) between patients with and without NCM. There were no cases of NCM regression.Conclusion. NCM is an independent form of DCM syndrome, which is characterized by higher frequency of pathogenic mutations, arrhythmic events, worse response to cardiotropic therapy, higher frequency of intracardiac thrombosis. The absence of mortality differences can be explained by the higher frequency of preventive interventions in this category of patients with DCM (prescription of anticoagulants, defibrillator implantation, heart transplantation).