bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of eco-friendly cobalt doped willemite blue pigment from white sand for multi-applications in coatings and inks
Authors: Abd El-Gawad Walaa M. , Abdelmaksoud Wael Mohamed 
Published: April 2022

Purpose
This study aims to investigate the possibility of synthesizing cobalt doped willemite ceramic blue pigment by using Egyptian white sand as environmental and economical raw material for multi-applications in coatings and inks.

Design/methodology/approach
After the synthesis process, the prepared blue pigment was characterized via X-ray diffraction, scanning electron microscopy and energy-dispersive X-ray analysis technique. Then the blue pigment was integrated into both coating and ink formulations. The effect of the prepared multifunctional coatings on corrosion resistance and thermal stability was evaluated using different standard tests. Also, the effect of inclusion of blue pigment in flexographic printing ink formulation was done.

Findings
The results showed that the coating containing the cobalt doped willemite blue pigment offered good anticorrosive performance and high thermal stability. Additionally, the presented results revealed that integration of the blue pigment in flexographic printing ink formulation enhanced fineness, gloss, viscosity and color more than the commercial one “FX 430–201.”

Originality/value
In conclusion, relied on the eco-friendly principle which can be regarded as an economic and green strategy, it can be obtained that this new pigment can provide good multifunctions such as corrosion resistance and thermal stability in coatings and good fineness, gloss, viscosity and color in inks which can enable them to be widely applied in different industries.
Why do young people do things for the environment? The effect of perceived values on pro-environmental behaviour
Authors: Ng Peggy Mei Lan , Cheung Cherry Tin Yan 
Published: April 2022

Purpose
This study aimed to develop an integrative model that comprehensively explores the antecedents of pro-environmental intentions in young people. The study follows customer value theory (CVT) and the theoretical framework of the theory of planned behaviour (TPB).

Design/methodology/approach
Data was obtained from a field survey of two secondary schools in Hong Kong. A total of 279 young people (age range: 10–12 years old; 53.8% males) were recruited to complete the survey. Smart-PLS 3 was used to test the research model with partial least squares structural equation modelling.

Findings
The findings provided empirical evidence that the perceived values of children regarding environmentalism play an essential role in developing pro-environmental attitudes and behavioural intentions, such as recycling intention and conservation intention. The results support the utility of TPB for its adoption of attitude and behavioural intention as key components of the model. The use of CVT showed that three dimensions of young people’s perceived values, namely, emotional value, functional value and relational value, predict a pro-environmental attitude, while attitude predicts recycling intention and conservation intention.

Practical implications
This study offers crucial insight for schools and the Education Bureau of the Hong Kong Special Administration Region government, who are focussed on spurring the perceived values, attitudes and behavioural intentions of young people towards environmentalism. This study shows that young people’s emotional values, functional values and relational values are important for transforming pro-environmental attitudes into behavioural intentions in young people.

Originality/value
This study measured the impact of young people’s perceived values on pro-environmental intentions. Few studies address how perceived values affect young people’s pro-environmental behaviour. This study integrates CVT and TPB to explore the source of young people’s pro-environmental intentions.
Presence of neutrophil extracellular traps in superficial venous thrombosis of Behçet’s disease
Authors: Kawakami Tamihiro , Yokoyama Kae , Ikeda Takaharu , Nishibata Yuka , Masuda Sakiko , Tomaru Utano , Ishizu Akihiro 
Published: April 2022

AbstractBehçet’s disease (BD) has a heterogeneous spectrum of disease manifestations featuring the involvement of different organs and can be characterized with different symptoms depending on the clinical department in charge. We retrospectively reviewed BD patients seen at our hospital and investigated the presence of neutrophils producing neutrophil extracellular traps (NET) in those patients. Immunolabeling of myeloperoxidase and histone citrullination proteins was performed on skin biopsies from three BD patients who had skin biopsy‐proven superficial vein thrombophlebitis in their erythema nodosum‐like lesions. We observed a higher proportion of female patients and a higher incidence of acne‐like eruptions among BD patients seen at our dermatology department, while there was a higher incidence of ocular and gastrointestinal involvement among BD patients treated in other departments. We suggest that sex statistical trends could lead to the co‐development of different manifestations and may help clinicians choose the best therapeutic approaches, tailoring them to the specific phenotype of the patient rather than one based on single disease manifestations. NET were found in neutrophils of panniculitis concurrent with superficial vein thrombophlebitis. We suggest that the pathogenesis of BD‐related thrombosis could be associated with neutrophil activation and NET are released in the panniculitis of affected skin lesions, erythema nodosum‐like lesions.
Methyltransferase‐like 3 promotes the progression of lung cancer via activating PI3K/AKT/mTOR pathway
Authors: Cheng Feng‐Wu , Peng Li‐Ming , Luo Dan 
Published: April 2022

AbstractMethyltransferase‐like 3 (METTL3) catalyses N6‐methyladenosine (m6A) modification on messenger RNA (mRNA) and participates in a wide range of biological functions via epigenetically regulating gene expression. Recent studies suggested that dysregulation of METTL3 is associated with multiple human cancers; however, the role of METTL3 in lung cancer remains unclear. In the present study, through transcriptome analysis of lung cancer patients, we found that METTL3 is overexpressed in lung cancer patients and is associated with poor patient survival. More importantly, combining both in vitro and in vivo models, we revealed that in lung cancer cells, METTL3 overexpression activates PI3K/AKT/mTOR pathway and mTOR‐mediated protein synthesis. Mechanistically, METTL3 promotes PI3K expression by introducing m6A modification in PI3K 3′ untranslated region (3′ UTR). Elevated PI3K level then activates downstream AKT and mTOR signalling pathway and results in rapid cancer cell proliferation and metastasis. Taken together, our study reveals that METTL3‐mediated m6A methylation promotes lung cancer progression via activating PI3K/AKT/mTOR pathway.
Efficacy and safety of plasma diafiltration: Review of case reports and case series
Authors: Zhang Yannan , Dong Rui , Li Ying , Yang Xin , Liu Jiang , Ou Santao , Wu Weihua 
Published: April 2022

AbstractPlasma diafiltration (PDF), a blood purification procedure that combines dialysis with plasma filtration by a selective membrane, has been used to treat acute liver failure, sepsis, and other acute conditions. We reviewed 14 eligible case reports and case series that examined PDF in 357 patients to assess its efficacy and safety. Fourteen diseases may be indications for PDF. The primary indication in the included studies was acute liver failure without obvious inducement or cause not mentioned. Eighty‐three patients reached the primary endpoint (31 deaths, 52 recoveries) and the efficacy was 62.7%. There were large changes in 16 toxins or clinical markers after PDF, including total bilirubin, IL‐18, IL‐6. In conclusion, PDF appears to be an effective treatment for clearance of bilirubin and other inflammatory mediators in patients with acute liver injury or a disease characterized by a systemic inflammatory state. Randomized controlled trials are needed to compare PDF with other blood purification methods, such as plasma exchange and the Molecular Adsorbent Recirculating System™.
What Motivates Households with Very Small and Small Farms in Wales?
Authors: Hill Berkeley , Bradley Dylan 
Published: April 2022

SummaryIn the UK, as in many EU countries, farm businesses are mostly operated by households rather than as other institutional forms. These are not only economic units – they have social dimensions too. Household members will have personal aims and preferences, shaped by psychology and experiences, that are reflected in behaviour. In Wales there is special interest in the motives of operators of farms classed as economically Very Small or Small, as these account for 87 per cent of all Welsh farms and thus carry social and political weight in agricultural and rural matters; they also occupy 60 per cent of the agricultural land area. Using questions developed from a review of literature (and especially work published by Ruth Gasson), a survey in early 2021 of over 400 farm households found that respondents overwhelmingly reported intrinsic factors as very important reasons for them being in farming, a categorisation that included motives such as enjoyment of the various production activities of farming, providing a healthy outdoor life, and giving them independence and control. In contrast, less than a third cited instrumental reasons, such as generating an income for living, and this was weakest among the operators of Very Small farm businesses. Social and expressive reasons for being in farming took intermediate positions. The dominance of intrinsic motivations was confirmed when scoring also took account of lower levels of importance cited by respondents. Understanding motives can lead to better explanations for how farm households respond to policy signals, such as are associated with the UK leaving the EU (‘Brexit’) and the replacement of the Common Agricultural Policy with a national one in Wales. Over three‐quarters of these farmers see environmental conservation as extremely or very important to their futures, which suggests that this element of the post‐Brexit Welsh agricultural policy will meet a welcoming response.
Multisphere Tectonics of the Earth System
Authors: REN Jishun , NIU Baogui , XU Qinqin , ZHAO Lei , LIU Jianhui , LI Shan , ZHU Junbin , LIU Renyan 
Published: April 2022

AbstractThe fundamental theoretical framework of the Multisphere Tectonics of the Earth System is as follows: (1) It intends to extend the geotectonic studies from the crustal and lithospheric tectonics to the multisphere tectonics of the Earth system as a whole. (2) The global dynamics driven by both the Earth system and the cosmic celestial system: solar energy, multispheric interactions of the Earth system and the combined effects of the motions of celestial bodies in the cosmos system are the driving forces of various geological processes. (3) The Continent‐Ocean transformation theory: the continent and ocean are two opposite yet unified geological units, which can be transformed into each other; neither continent nor ocean will survive forever; there is no one‐way development of continental accretion or ocean extinction; the simple theory of one‐way continental accretion is regarded as invalid. (4) The continental crust and mantle are characterized by multiple layers, with different layers liable to slide along the interfaces between them, but corroboration is needed that continents move as a whole or even drift freely. (5) The cyclic evolution theory: the development of Earth's tectonics is not a uniform change, but a spiral forward evolution, characterized by a combination of non‐uniform, non‐linear, gradual and catastrophic changes; different evolutionary stages (tectonic cycles) of Earth have distinctive global tectonic patterns and characteristics, one tectonic model should not be applied to different tectonic cycles or evolutionary stages. (6) The structure and evolution of Earth are asymmetric and heterogeneous, thus one tectonic model cannot be applied to different areas of the world. (7) The polycyclic evolution of the continental crust: the continental crust is formed by polycyclic tectonics and magmatism, rather than simply lateral or vertical accretion. (8) The role of deep faults: the deep fault zones cutting through different layers of the crust and mantle usually play important roles in tectonic evolution. For example, the present‐day mid‐ocean ridge fault zones, transform fault zones and Benioff zones outline the global tectonic framework. Different tectonic cycles and stages of Earth's evolution must have their own distinctive deep fault systems which control the global tectonic framework and evolutionary processes during different tectonic cycles and stages. Starting from the two mantle superplumes Jason (Pacific) and Tuzo (Africa), the study of the evolutionary process of the composition and structure of the crust and mantle during the great transformation and reorganization of the Meso‐Cenozoic tectonic framework in China and the other regions of Asia is a good demonstration of theory of Multisphere Tectonics of the Earth System.
“On a night like this”: A mixed‐methods approach to understanding high‐risk drinking events in college students
Authors: Garcia Tracey A. , Hultgren Brittney A. , Canning Jessica R. , Gilson Michael S. , Larimer Mary E. 
Published: April 2022

AbstractBackgroundPrevious research indicates college students report heavier drinking on certain events (e.g., 21st birthday). While past research has identified heavier drinking events, students’ own reports of which events are associated with elevated drinking remains understudied. The current study utilized mixed methods to explore potential high‐risk drinking events (HRDE) for college student drinkers and how these events differed from typical drinking and each other.MethodsCollege student drinkers (N = 204) reported the number of drinks they consume on nine predetermined events (e.g., Halloween). Students also responded to open‐ended questions listing five events during which they had elevated drinking and indicating the amount consumed on each event. Open‐ended responses were coded into similar event categories. Descriptive statistics for drinks consumed were calculated for predetermined and coded open‐ended events. Chi‐square analyses assessed differences in endorsement of open‐ended events by birth sex, age group, and Greek membership. Two multilevel count regressions assessed within‐person differences in number of drinks consumed between participants’ typical drinking occasions and (1) highly endorsed open‐ended events and (2) predetermined events.ResultsFor all open‐ended event categories, average number of drinks consumed exceeded heavy episodic drinking thresholds; however, there was substantial variability. Comparing predetermined events to participants’ typical drinking indicated elevated drinking on participants’ birthdays, New Year's Eve, Halloween, Finals, and Spring Break; significant differences between events also emerged. Comparison of open‐ended categories to participants’ typical drinking indicated elevated drinking on birthdays, celebrations, parties, and holidays; however, there were no significant differences between open‐ended events.ConclusionsStudents who drink alcohol report heavier drinking on specific calendar‐based events (e.g., Spring Break). However, students also report non‐calendar‐related events (e.g., non‐specific parties) as some of their highest drinking events. More research is needed to understand how intervention and prevention programs can be adapted to target both known calendar‐based HRDE, and unknown, idiosyncratic HRDE.
No significant association between SNPs in the CLOCK and ADH4 genes and susceptibility to cluster headaches: A systematic review and meta‐analysis
Authors: Cui Jiarui , Peng Wei , Yi Ting , Gao Ping , Zhou Mingze , Zhu Tianmin 
Published: April 2022

AbstractBackgroundThe circadian locomotor output cycles kaput (CLOCK) gene and the alcohol dehydrogenase 4 (ADH4) gene are promising candidates for susceptibility to cluster headaches (CH). Associations of the three single nucleotide polymorphisms (SNPs)—CLOCK SNP rs1801260 and ADH4 SNPs rs1800759, and rs1126671—with CH were studied previously, but the results were inconsistent.MethodsAssociations between the three SNPs (rs1801260, rs1126671, and rs1800759) and CH risk were separately assessed by pooled odds ratios (ORs) along with 95% confidence intervals (95% CIs) based on five different genetic models. Methodological quality was assessed using the Newcastle–Ottawa Quality Assessment Scale (NOS). All statistical analyses were carried out with RevMan 5.3 software.ResultsEight studies involving 1437 CH patients and 2541 healthy controls were selected for quantitative synthesis, from five studies on CLOCK rs1801260, five on ADH4 rs1800759, and three on ADH4 rs1126671. Our pooled data did not support associations between the three SNPs (rs1801260 in the CLOCK gene, rs1800759 and rs1126671 in the ADH4 gene) and susceptibility to CH (rs1801260: OR 1.10, 95% CI: 0.95–1.28; p = 0.19; rs1800759: OR 1.06, 95% CI: 0.93–1.22; p = 0.37; and rs1126671: OR 1.09, 95% CI: 0.92–1.28; p = 0.32).ConclusionWe found no significant associations between the three SNPs (rs1801260 in the CLOCK gene and rs1800759 and rs1126671 in the ADH4 gene) and the susceptibility to CH across both Caucasian and Asian ethnicities in our meta‐analysis.
Factors associated with readmission to alcohol and opioid detoxification in the Alaska Interior
Authors: Running Bear Ursula , Hanson Jessica D. , Noonan Carolyn , Muller Clemma , Trojan Jodi , Manson Spero M. 
Published: April 2022

AbstractBackground and ObjectivesA “revolving door” of repeated admissions to detoxification treatment facilities has long plagued alcohol and drug use patients, yet few studies examine factors associated with readmission. This study examined risk factors for readmission to alcohol and opioid detoxification in a sample from the Alaska Interior.MethodsData were extracted from electronic medical records for admissions between 2012 and 2016 at an inpatient detoxification facility in Fairbanks, Alaska. Data from 1014 patients admitted for alcohol detoxification and 267 patients admitted for opioid detoxification were analyzed. The analysis employed descriptive statistics for risk factors (substance use history, adverse life experiences, and psychosocial functioning) and prevalence of readmission to either alcohol or opioid detoxification. Inferential analyses used marginal standardization to calculate differences in readmission risk by patient characteristics.ResultsMale, Alaska Native/American Indian, single‐never married patients, and those seeking work were at higher risk for readmission to alcohol detoxification, while those with stable housing were at reduced risk. Being single‐never married and completing detoxification treatment reduced readmission to opioid detoxification. Family involvement in detoxification reduced readmission risk for both alcohol and opioid patients.Discussion and ConclusionsFurther research that investigates the mechanism(s) by which family may act as a protective factor may be efficacious in eliminating the “revolving door” of detoxification.Scientific SignificanceThis study is the first to examine both alcohol and opioid use risk and protective factors in the Alaska Interior. The results can be used in the development of interventions for subpopulations with high detoxification readmission rates.
The role of social media in management of individuals with endometriosis: A cross‐sectional study
Authors: van den Haspel Kelly , Reddington Charlotte , Healey Martin , Li Rebecca , Dior Uri , Cheng Claudia 
Published: April 2022

BackgroundTo better understand the potential role of social media (SM) as a self‐management tool for individuals with endometriosis and to assess its current use by endometriosis patients.AimsThe primary outcome was use of SM for health in patients with endometriosis. Secondary outcomes included preferred SM platforms for health information sharing and factors that influenced use, positive and negative experiences and reported impacts on health.Materials and MethodsA single‐centre, cross‐sectional study performed within benign gynaecology units at a tertiary hospital in Melbourne, Australia. One hundred patients with a confirmed diagnosis of endometriosis participated. Individuals did not have to be users of SM. Data were collected through an electronic third‐party survey tool (SurveyMonkey®). Analysis methods included descriptive statistical analysis, frequency counts, as well as cross‐tabulation to examine statistical association between variables. Free‐text responses were qualitatively analysed using deductive‐inductive semantic thematic analysis.ResultsSocial media was used for health by 76% of patients with endometriosis in this study. SM users were younger, had pelvic pain for more than six months and reported higher rates of psychosocial impact and symptoms from endometriosis. Respondents reported overall positive impacts on psychological, social and cognitive health outcomes (76%) from SM use.ConclusionIn our cohort, a high number of people with endometriosis are using SM for health. These individuals are more likely to suffer both physical and psychosocial impacts from endometriosis. Hospitals and health organisations may consider support of the endometriosis community through SM.
A cross‐sectional survey of Australian healthcare professionals' confidence, evidence‐based knowledge and guideline use for antenatal asthma management
Authors: Wright Thomas K. , McLaughlin Karen , Jensen Megan E. , Robijn Annelies L. , Foureur Maralyn , Murphy Vanessa E. 
Published: April 2022

BackgroundAsthma is one of the most common chronic health conditions experienced during pregnancy and is associated with numerous adverse maternal and perinatal outcomes.AimsTo better understand the confidence, evidence‐based knowledge and guideline use among healthcare professionals around Australia commonly involved in providing antenatal care for women with asthma.Materials and MethodsAn online, cross‐sectional survey was developed and distributed to maternity carers (obstetricians and midwives), primary carers (general practitioners and general practice nurses) and respiratory specialists (respiratory physicians and respiratory nurses). Self‐reported confidence and use of clinical guidelines were recorded. Evidence‐based knowledge was assessed with 13 questions relating to four clinical scenarios that covered recommendations from national and international guidelines.ResultsPrimary carers and respiratory specialists were more confident in providing antenatal asthma care, more likely to use clinical guidelines and scored significantly higher in evidence‐based knowledge of antenatal asthma management than maternity carers (P < 0.01 and P < 0.001, respectively). There was no significant difference in evidence‐based knowledge among healthcare professionals from metropolitan, regional and rural backgrounds. However, healthcare professionals who used clinical guidelines scored significantly higher than those who did not (P < 0.0001).ConclusionGreater utilisation of clinical guidelines could improve the evidence‐based knowledge of maternity carers. However, the absence of antenatal asthma management in obstetric‐ and maternity‐specific guidelines poses a potential barrier that needs to be addressed. Furthermore, the development of multidisciplinary antenatal clinics, staffed by respiratory nurses and/or physicians, could improve outcomes for pregnant women with asthma who are not undertaking shared care.