bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of filaggrin mutations leading to a decrease in the amount of protein in the development of atopic dermatitis and bronchial asthma in children
Authors: Makarova S. I. , Mitrofanov D. V. , Komova E. G. , Kaloshkin I. V. , Shintyapina A. B. , Kaznacheeva L. F. , Zelenskaya V. V. , Kondyurina Е. G. , Batychko О. A. , Vavilin V. A. 
Published: February 2022

Atopic diseases remain one of the most common childhood diseases. At the beginning of life, atopic dermatitis (AD) occurs, and only then bronchial asthma (BA). This staged development of sensitization and transformation of clinical manifestations is called the atopic march. Are the genetic factors of predisposition to AD the same for BA? There is still no definite answer to this question. Mutations in the filaggrin gene (FLG) are known to impair skin barrier function. Filaggrin is expressed not only in the skin, but also in the respiratory organs of the nasal mucosa, lungs, and bronchi. Filaggrin defects lead not only to disruption of the skin barrier, but also to an increase in the Th2 response and increased production of IgE, typical of bronchial asthma. Therefore, mutations in the FLG gene can be a risk factor for the development of not only AD, but also BA.The aimof this study was to compare the values of the association of mutations in the FLG gene with AD and BA in the Russian sample.Material and methods.Case-control study design. We used 265 blood samples from children. 4 mutations in the filaggrin gene were identified by real-time PCR. The association of mutations with disease was assessed by odds ratio.Results.We showed a strongly pronounced association of the deletion of 4 nucleotides (2282del4) with AD, but not with BA, although for patients with atopic BA the indicator of the association of this mutation with the disease was higher than for the group with symptoms of bronchial asthma identified by the ISAAC questionnaire. These results lead to the conclusion that the role of the filaggrin gene for BA is much less significant than for AD.
Ultrastructural analysis of changes in myocardial blood microvessels in severe burn shock
Authors: Savchenko S. V. , Oshchepkova N. G. , Bgatova N. P. , Taskaeva Yu. S. , Kuznetsov E. V. , Novoselov V. P. , Letyagin A. Yu. 
Published: February 2022

Burn injury is an important medical problem, as it is accompanied by high mortality rates in burn shock. Aim of the study was to conduct an ultrastructural stereological analysis of changes in the blood microvessels of the left ventricular myocardium in burn shock.Material and methods. Myocardial samples during the early section were collected 2 hours after the detection of biological death in the victims from severe burn shock (3 men and 2 women); age group 32-44 years. An ultrastructural study of endothelial cells of the microvasculature of the left ventricular myocardium was carried out.Results and discussion. The development of severe burn shock is accompanied by changes in the ultrastructure of the endothelial cells of the blood microvessels of the left ventricular myocardium, which is associated with intracellular degradation and exocytosis. These ultrastructural changes may indicate impairment of vesicular transport in the endothelium of the myocardial microvessels in burn shock. A feature of the ultrastructure of the endothelium was the heterogeneity of the endothelial cells of the blood capillaries due to the revealed dark and light endothelial cells, which differ in the saturation of the cytoplasm with organelles. The new data obtained on changes in the ultrastructure of the endothelium of the microvasculature of the left ventricular myocardium can be informative in the development of approaches to intensive therapy of cardioprotective direction in combustiological patients with burn shock.
Prevalence of CHD possibly presence in a sample epidemiological study, taking into account the socio-economic characteristics of the participants
Authors: Agienko A. S. , Tsygankova D. P. , Bazdyrev E. D. , Mulerova T. A. , Indukaeva E. V. , Artamonova G. V. 
Published: February 2022

Aim of the study was to analyze the socio-economic determinants and prevalence of possibly presence CHD in residents of a large industrial region.Material and methods. The study sample included residents of rural settlements of the Kemerovo region and districts of the city of Kemerovo. The study involved 1600 respondents aged 35-70 years. The determinants of socio-economic status (SES) were assessed: the level of education and income, professional affiliation, marital status / family composition, place of living.Results. The majority residents of rural settlements (50.9 %) had a secondary vocational education, compared with urban residents (46 %). A high level of income (over 20 000 rubles) was observed 1.53 times more often among the urban population than rural population. It was revealed that one third (29.3 %) of the rural population is employed in agriculture, and about 40.4 % do work that does not require vocational qualification. Among residents of rural settlements, there are statistically significant more those marriage/living with a partner, than among urban residents (75.6 % versus 62.9 %, respectively). The SES analysis of the study participants with possibly presence CHD indicates a predominant share (50.9 %) of vocational secondary education and medium income level (48.9 %). It was revealed that among the lonely rural residents possibly presence CHD occurred 10.0 % more often (urban 26.7 %, rural 36.7 %, p = 0.035) than among those living in the city.Conclusion. In the Kemerovo Oblast CHD possibly presence is more common in women, depending on socio-economic determinants it is more often observed in persons with a secondary vocational education and medium income level, equally among both skilled and low/ unskilled workers living with partner in urban settings.
Microcirculatory and metabolic changes in soft tissues in the dynamics of the wound process in explosive trauma with acute blood loss in an experiment
Authors: Shperling I. A. , Vinogradov M. V. , Semakin R. V. , Shperling N. V. , Shulepov A. V. , Rostovtsev S. O. , Kourov A. S. , Bazhenov M. V. 
Published: February 2022

The aim of the study was to evaluate microcirculatory and metabolic changes in damaged skeletal muscles in rats with experimental explosive trauma with acute blood loss. Material and methods. An experimental model of explosive damage to the soft tissues of the pelvic limb in rats was used to assess microcirculation and metabolic activity in the muscles of the area of the explosive wound by laser Doppler flowmetry and laser fluorescence diagnostics using the LAKK-M device. Results and discussion. It was found that during the entire follow-up period (28 days), pronounced disorders of microcirculation and metabolism were formed in the damaged muscles. Tissue perfusion was significantly reduced, which is confirmed by a change in the coefficient of variation of the microcirculation index, the value of which was lower by 36–51 % (p < 0.05) in all follow-up periods in animals from the intact group, and the maximum decrease in the indicator was observed by 28 days (6.7 (6.3; 7.4) %, at p < 0.05). Tissue metabolism was rearranged in the direction of activation of the anaerobic pathway: there was a decrease in the index of specific oxygen consumption by the tissue – by 2.3 times (p < 0.05), the fluorescent index of oxygen consumption by the tissues – by 60 % (p < 0.05), the integral index of oxygen exchange efficiency by an average of 8.5 times (p < 0.05) relative to healthy animals, which generally indicated weak oxygen utilization by the tissues. These disorders of metabolism and oxygen consumption by the tissues of the damaged area persisted throughout the experiment with a slight positive dynamics by the end of the observation period. Conclusion. The obtained data are a pathogenetic justification for the development of means for the local correction of microcirculatory and metabolic disorders in the muscles in the case of explosive trauma in the post-traumatic period.
Métodos alternativos para otimização e reaproveitamento energético em sistemas de bombeio mecânico de hastes na indústria de petróleo: um estudo bibliométrico
Authors: SOUZA LEANDRO FERREIRA 
Published: February 2022

O processo de extração de petróleo consome muita energia elétrica e isto aumenta os custos de produção. O sistema de bombeio mecânico de hastes representa cerca de 85% dos sistemas de elevação usados na produção de campos onshore. Este artigo objetiva investigar o que está sendo discutido sobre métodos alternativos para otimização e reutilização energética para estes sistemas. Para isso, conduziu-se um estudo bibliométrico para investigar a relação entre reaproveitamento energético e as unidades de bombeio mecânico com hastes na indústria do petróleo. O número de artigos publicados encontrados foi bem reduzido, o que sugere um assunto que ainda carece de muitas pesquisas. Mesmo assim, foi possível identificar algumas tendências de estudos, como a inserção de molas no sistema para armazenar energia potencial elástica, além de acompanhar a discussão sobre as formas eficazes de reciclagem de energia, cujo desenvolvimento sugere a avaliação de fontes secundárias de energia e o uso de fontes renováveis de energia como etapas que devem ser executadas. Foi possível compreender que os estudos nessa área possuem projeção de aumentar e que alguns novos sistemas já estão sendo testados.
Factores psicosociales asociados a trastornos depresivos en pacientes del Hospital Central de Nampula, Mozambique.
Authors: Vázquez Machado Andrés , Mukamutara Julienne 
Published: February 2022

Objetivo: Identificar factores psicosociales claramente asociados a depresión en una población susceptible. Material y Métodos: Estudio transversal en 347 pacientes con diagnóstico de depresión y 168 sin trastornos mentales ni síntomas psicológicos actuales, atendidos en un hospital de Mozambique, entre febrero de 2014 y enero de 2017. Se estudiaron variables socio-demográficas así como algunos eventos adversos tempranos y eventos vitales actuales. Se condujeron análisis bivariados, utilizando chi cuadrado y odds ratio. Resultados: Se encontró una asociación significativa (p<0,05) entre los trastornos depresivos y factores socio-demográficos como 34 años de edad o menos, ser divorciado o soltero, desempleado y tener entre ninguno y dos hijos. El promedio de eventos adversos fue de 2,4 entre los deprimidos y 0,6 entre los no deprimidos. Eventos adversos (i.e., violencia intrafamiliar y muerte de uno de los padres, entre los más frecuentes) durante la edad temprana se asociaron con depresión en la adultez, incrementando en 5 veces tal probabilidad, en tanto que la ocurrencia de 2 o más eventos en la etapa actual generó el mismo resultado. Los más comunes fueron los conflictos interpersonales y el padecimiento de una enfermedad física. Conclusiones: Experiencias adversas en la infancia y diversos eventos vitales actuales son más frecuentes en pacientes con trastornos depresivos que en pacientes sin depresión, confirmando su vigencia como factores psicosociales de riesgo.
Lamp Light Exposure During Sleep and Sleep Quality of Medical Student Universitas Airlangga Batch 2012
Authors: Pradnyaparamitha Dyah Ayu , Soebagjo Hendrian Dwikoloso , Sari Gadis Meinar 
Published: February 2022

Introduction: Sleep disorder commonly happens to teenagers and adults because of light exposure during sleep that affects sleep quality, but the relation of lamp light exposure during sleep and sleep quality of medical students hasn’t been determined previously. Objective: This research aimed to determine the relation of lamp light exposure and sleep quality of Universitas Airlangga’s medical students and to give further information about the right adjustment of lamp light exposure to improve the sleep quality of medical student. Methods: Variables in this cross-sectional designed research were lamp light exposure (on or off) as the independent variable and sleep quality as a dependent variable. The research used the PSQI questionnaire to decide the sleep quality of 115 subjects once a week in a month. The collected data were analyzed by chi-square and fisher’s exact test. Results: Based on the chi-square test, the p-value for lamp light exposure and sleep quality was more than 0.05 (p = 0.863). The results also showed that 74.8% of medical students had bad quality sleep. Conclusion : In conclusion, there was no relation between lamp light exposure and sleep quality. This research also indicated that most of the subjects had a bad sleep quality so that student should increase their needs for better sleep quality to maintain performance.
Role of Procalcitonin in Intracerebral Hemorrhage Stroke with COVID-19
Authors: Sari Ita Muharram , Erwin Iswandi , Baqarizky Fiizhda , Oktaviani Puspa , Salam Sardiana , Ritonga Anna Mardiana 
Published: February 2022

Introduction: As COVID-19 has rapidly spread worldwide, it is an urgent health problem. Some evidence suggests that SARS-CoV-2 also affects the central nervous system. Stroke is the most common disease of the central nervous system. In contrast to ischemic stroke, which can occur due to the hypercoagulation effect of COVID-19, the study of Intracerebral Hemorrhage (ICH) associated with COVID-19 is still unclear. Objective: This paper investigated the characteristics of an inflammatory biomarker and compared the outcomes of ICH patients with COVID-19 and ICH patients without COVID-19. Methods: We conducted a retrospective, observational analysis case-control of patients (n = 42) admitted with ICH with positive COVID-19 and ICH with negative COVID-19 at the National Brain Center Hospital Prof.Dr.dr. Mahar Mardjono from March 2020 to August 2021. We took blood samples and COVID-19 swab PCR on the first day of admission, and GOS was measured when the patients were discharged. Results: There were 21 ICH patients with positive COVID-19 who had a significantly procalcitonin (p < 0.05) compared to control patients. From Spearman’s correlational analysis, there is a significant value between early procalcitonin and the Barthel Index (rs = -0,374, p < 0.05), early CRP and GOS (rs =- 0.329, p < 0.05), which indicates weak-inverse correlation, and between early PCT and GOS (rs = -0.438, p < 0.05) which indicates moderate-inverse correlation. Conclusion: The level of procalcitonin was increased in ICH patients with COVID-19. Maybe PCT could be a predictor of outcome in ICH patients with COVID-19.
Biofilm Formation and Antimicrobial Resistance of Escherichia coli in vitro Towards Ceftriaxone and Cefixime
Authors: Kalishah Jihan , Husada Dominicus , Arfijanto M Vitanata , Wahyu Widodo Agung Dwi 
Published: February 2022

Introduction: Escherichia coli is a Gram-negative bacteria and a most cause of nosocomial infections. Bacteria has the ability to form biofilm that may cause antimicrobe resistance. This biofilm protects the microbes from environmental conditions which make it the most cause of nosocomial infections including urinary tract infection and the infections resulted from the use of medical instruments. The aim of this experiment is to observe the presence of cefotaxime and ceftriaxone antimicrobial resistance in E. coli as a cause of biofilm formation. Method: This study conducted three experiments of E. coli sensitivity test on cefotaxime and ceftriaxone, E. coli resistance test after a 48 hours incubation, and optical density measurement using iMark™ ELISA Microplate Reader. Result: The results of sensitivity experiment with antibiotic cefotaxime and ceftriaxone disk showed sensitive result in wild-type E. coli and E. coli ATCC while after 48 hours incubation E. coli ATCC remains sensitive and in wild-type E. coli result are three intermediates, one sensitive and other than that it’s all change to resistance. The third experiment results were obtained from ELISA then classified into three categories. In E. coli ATCC 1 and 2, the results are mostly in high category (OD >0.240). The OD in E. coli 1 is mostly high, while results from E. coli 2 consists of one bacterium in weak category (OD <0.120), four in moderate category (OD 1.20 – 0.240), and three in high category. Conclusion: It can be concluded that E. coli resistance test in cefotaxime and ceftriaxone after 48 hours’ incubation are mostly resistant in wild-type E. coli but sensitive in E. coli ATCC.
Pendampingan Penyusunan LKPD berbasis Scientific Approach pada Guru Sekolah Dasar
Authors: Haryanto Haryanto , Wuryandani Wuri , Suwarjo Suwarjo , Hidayah Ratna , Erviana Vera Yuli , Mahfuzah Ainun 
Published: February 2022

<p class="Abstract">Assignment to use students worksheet as an alternative teacher to support learning during a pandemic. This training activity aims to improve the ability of teachers in compiling and developing students worksheet based on the Scientific Approach in learning. This activity was carried out in collaboration with the coordinator of the Sendangtirto Cluster Elementary School, Berbah, Sleman. This activity involved 30 elementary school teachers as participants, with a training model. Data on increasing the ability of participants was obtained through a questionnaire. Based on the data obtained, there was an increase in the assessment and ability of teachers towards the preparation and use of students worksheet based on the scientific approach after participating in this training activity into high and very high categories. After the training, participants are able to prepare students worksheet based on a scientific approach and implement it in learning.</p>
Educación acuática para la prevención
Authors: Ortiz Ana , Pinto Rita , Moreno-Murcia Juan Antonio , Albarracín Apolonia 
Published: February 2022

Antecedentes: Los ahogamientos son un importante problema de salud pública, con más de 320.000 muertes al año en todo el mundo. Años de investigación y concienciación sobre la necesidad de un cambio en los planteamientos de enseñanza acuática, han destacado en la actualidad, la necesidad de que ésta sea dirigida hacia la adquisición de la competencia que conlleve un real dominio del medio acuático, así como un descenso en las lesiones y ahogamientos en el mismo.
Objetivo: El objetivo de este documento es mostrar un posicionamiento sobre la educación acuática con una orientación claramente preventiva.
Método: Se revisaron las principales aportaciones bibliográficas a nivel internacional sobre la prevención de ahogamientos así como sobre los temas relativos a la educación acuática preventiva.
Resultados: Una vez identificadas las subcompetencias que tendrán que ser abordadas, se detallan, así como las recomendaciones pedagógicas para cada una de ellas. Basado en ello, emergen recomendaciones generales para llevar a cabo todo el proceso educativo, destacando la necesidad de concienciación de toda la población para lograr una prevención de ahogamiento integral de forma universal.
Conclusiones: Se podría destacar que, de forma general, la educación acuática debe dar un salto cualitativo, sobrepasando la idea de “saber nadar” como único recurso para no ahogarse. Dando paso a nuevas concepciones y metodologías que sean significativas, y sobre todo que tengan transferencia a entornos variables y en circunstancias de riesgo, no olvidando la situaciones individuales y colectivas en el proceso con una perspectiva cultural adecuada.
Palabras clave: prevención, educación acuática, ahogamientos, competencia acuática, medio acuático, transferencia competencias.
Photo-Fenton performance and mechanism of g-C3N4/FeOCl nanocomposite under simulate sunlight
Authors: Ma Jinhuan , Wei Zhiqiang , Lu Qiang , Li Chao , Li Ling 
Published: February 2022

Abstract
g-C3N4/FeOCl nanocomposites are prepared by a simple calcination method according to the different composite mass ratios of g-C3N4 and FeOCl. The microstructure and morphology were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), high-resolution transmission electron microscopy (HRTEM). It is found that the composite samples are mainly composed of FeOCl phase, and the presence of g-C3N4, indicating the successful composite of the sample without destroying the crystal structure of FeOCl. Through Electrochemical impedance spectroscopy (EIS) and transient photocurrent response, it is found that the photoelectrochemical performance of the composite sample g-C3N4/FeOCl-2 is stronger than that of pure FeOCl. In addition, through photo-Fenton and radical-trapping experiments, it is found that g-C3N4/FeOCl-2 degrades 92% of Rhodamine B (RhB) within 90 min, and ·OH radicals play an important role in the process of photo-Fenton degradation. The enhanced photocatalytic performance is mainly ascribed to the Z-type heterojunctions between FeOCl and g-C3N4, preventing the recombination of photogenerated electrons and holes, and improving the absorption efficiency of natural light. In this work, the high-efficiency photo-Fenton performance of g-C3N4/FeOCl-2 provides a new idea about the modification of pure FeOCl.
Viscoelastic Polyurethane Foams From Unmodified Kraft Lignin Dispersed Into Methoxy Polyethylene Glycol and Palm Kernel Oil as Substitutes of Petroleum-Based Polyols
Authors: Flôres Camila Campos , Rufino Thiago do C. Rufino C , Nahra Lara Robert , Rodrigues Isabelle Christine Zavecz , Oliveira Mauricio Pinheiro 
Published: February 2022

Abstract
Kraft lignin (KL) dispersions in methoxy polyethylene glycol (MPEG) and in a mixture of palm kernel oil (PKO) with MPEG (PKO/MPEG) were evaluated for viscoelastic polyurethane foams (VPFs) production with different contents of KL (0-3.9 pphp) and PKO (0 -15 pphp). The influence of the dispersed KL on the foam structure, foam growth profile, foaming reactivity, mechanical properties, and final properties of VPFs were studied. The appearance of the VPF produced with KL dispersion in MPEG/PKO was similar to the control VPF foam. The addition of KL dispersion (0 to 15 pphp), had a significant effect on the growth profile, foaming reactivity, density and consequently on the foam morphology. VPFs produced with 3.9 pphp of KL presented shrinkage values about 4 times when compared to the control. The presence of the KL and PKO did not improve the burning rate of the foam samples compared to the control foam, without KL and PKO. Thermal stability of the produced foams showed no relevant differences regardless of the contents of KL/MPEG/PKO used in comparison to the control. Mechanical properties of VPF can be adjusted by making changes to the standard formulation. It can be concluded that the dispersion of KL in a mixture of MPEG and PKO represents an alternative for incorporating fractions of KL and PKO into VPF. In addition, this study provides new insights for the production of VPF using renewable resources for packaging applications, as well as in the mattress industry.
Perspectives of Redox-Active Ligands in Artificial Photosynthesis
Authors: Benkó Tímea , Lukács Dávid , Li Mingtao , Pap József Sándor 
Published: February 2022

Abstract
Organic ancillary ligands can cooperate with metal centers in different ways in molecular catalysts of the very important oxygen evolving reaction. In this overview, we focus on what can be gained of such a cooperation and bring examples on the possible useful outcomes of redox state changes in ancillary ligands. Analogies are also highlighted if apply, with the cooperation between the natural oxygen evolving complex and the redox-mediating Tyrosine-Histidine pairs found in photosystem II.