bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adalimumab for the Treatment of Pediatric Populations With Non-Infectious Uveitis
Authors: Hui Daphne , Mierzwinski-Urban Monika , Spry Carolyn 
Published: March 2022

Two systematic reviews, 1 economic evaluation, and 2 evidence-based guidelines were identified regarding the clinical effectiveness (including safety), cost-effectiveness, and use of adalimumab in pediatric populations with non-infectious uveitis.
Pooled data of the SYCAMORE and ADJUVITE randomized controlled trials comparing adalimumab to placebo demonstrated that adalimumab significantly increased the likelihood of reducing or interrupting corticosteroid use (which is beneficial as long-term corticosteroid use can result in cataracts and glaucoma). Adalimumab significantly increased the event of a satisfactory response rate, but there was no difference in safety assessed as systemic adverse events and local adverse effects.
Specific to the ADJUVITE trial, visual acuity slightly worsened before and after treatment with adalimumab and it was unclear if adalimumab increased control of intraocular inflammation.
Specific to the SYCAMORE trial, adalimumab significantly lowered the risk of treatment failure and the rate and number of adverse events and serious adverse events were higher in the adalimumab group compared to the placebo group. For the adalimumab group, the most common adverse event type was infections and infestations and the most common serious adverse events were glaucoma, cataracts, injection site reactions, arthritis, and arthralgia.
In the perspective of the health care system in the UK, adalimumab plus methotrexate was not found to be cost-effective compared to methotrexate alone (modelled by placebo data) in uveitis associated with juvenile idiopathic arthritis.
Cost-effectiveness analyses of adalimumab at a discounted price lowered the incremental cost-effectiveness ratio, which supports the potential use of biosimilars in the future due to cost savings.
Both guidelines recommended the use of treatment that blocks proteins that cause inflammation (tumour necrosis factor-alpha inhibitors) such as adalimumab in combination with an immunosuppressive agent such as methotrexate (i.e., adalimumab plus methotrexate) in patients with uveitis associated with juvenile idiopathic arthritis who are not responsive to initial treatment (e.g., topical corticosteroids) and are at risk for severe uveitis or vision threatening complications.
The American College of Rheumatology/ Arthritis Foundation recommended the use of adalimumab and infliximab over etanercept with no preference between adalimumab and infliximab. Conversely, the guideline from multiple interdisciplinary German groups recommended that adalimumab and infliximab are the first- and second-choice tumour necrosis factor-alpha inhibiting drugs, respectively. They recommended a treatment switch to infliximab then golimumab when adalimumab is not effective or there is treatment failure with adalimumab.
Food quality and safety. Transformation of concepts
Authors: Хуршудян Сергей Азатович , Пряничникова Наталия Сергеевна , Рябова Анастасия Евгеньевна 
Published: March 2022

Продукты питания, несомненно, способствовали развитию и поддержанию человечества. Сегодня мы сталкиваемся с серьезными проблемами в этой области - многие люди потребляют продукты низкого качества. Качество и безопасность пищевого продукта - это одно из основополагающих понятий, используемых в госпрограммах, нормативных и иных документах различных уровней, которые затрагивают вопросы обеспечения населения продуктами питания. При этом восприятие терминов у потребителей и производителей отличается. Так, в статье приведен анализ существующих определений качества и безопасности пищевых продуктов, факторы, формирующие их восприятие у потребителя, а также трансформация их содержания во времени под влиянием различных факторов или их комбинаций. Расширение границ потребительского восприятия качества и безопасности в зарубежной технической литературе также признается существенным фактором, для которого применяется специальное название - «метод лестницы». Примером субъективного восприятия качества может служить априорное отношение потребителя к пищевым продуктам известных торговых брендов. Границы безопасности меняются значительно медленнее, чем качественные показатели. В реальности показатели безопасности, прежде всего, становятся известными специалистам, и лишь отдельные, наиболее агрессивные - потребителям.
Food products undoubtedly contributed to the development and maintenance of mankind. Today we are facing serious problems in this area - many people are consuming poor quality products. The quality and safety of a food product is one of the fundamental concepts used in state programs, regulatory and other documents at various levels that affect the provision of food to the population. At the same time, the perception of terms by consumers and manufacturers is different. Thus, the article analyzes the existing definitions of food quality and safety, the factors that shape their perception by the consumer, as well as the transformation of their content over time under the influence of various factors or their combinations. The expansion of the boundaries of consumer perception of quality and safety in foreign technical literature is also recognized as a significant factor for which a special name is used - the «ladder method». An example of the subjective perception of quality is the a priori attitude of the consumer to food products of well-known trade brands. Security boundaries change much more slowly than qualitative indicators. In reality, safety indicators, first of all, become known to specialists, and only some, the most aggressive ones, to consumers.
Membangun Spiritualitas Kristen Warga Binaan di Lapas Umum Kelas II A Tanjungpinang
Authors: Simanjuntak Fredy , Marisi Candra Gunawan , Lahagu Ardianto , Purba Benteng M. M. , Sihombing Agustinus 
Published: March 2022

Spirituality is the value or understanding possessed by humans in behaving with one another, even their relationship with God which is influenced by the environment, experience and knowledge. Every human being has Spirituality in him, and spirituality affects both individual behaviour in society or other individuals. The Indonesian state by law certainly has the goal of creating good community conditions in the midst of society. The state wants the assisted citizens or Correctional Institution communities to receive guidance in order to create this good condition. However, this wish has not been carried out properly, due to a lack of experts. So how does Christianity view this? Certainly the question will arise as well what should be done to bring the assisted people from living the wrong way to the right direction by cultivating their spirituality and of course teaching them Christian spirituality. AbstrakSpritualitas adalah nilai atau pemahaman yang dimiliki oleh mansuia dalam berperilaku satu dengan yang lainya bahkan hubungan dengan Tuhan yang dipengaruhi oleh lingkungan hidup, pengalaman dan pengetahuan. Setiap manusia memiliki Spiritualitas dalam dirinya, dan spritiualitas mempengaruhi baik buruknya perilaku individu ditengah-tengah masyarakat atau terhadap individu lainnya. Negara Indonesia secara hukum tentunya memiliki tujuan agar terciptanya kondisi masyarakat yang baik ditengah-tengah masyarakat. Negara ingin warga binaan atau masyarakat lapas mendapat binaan agar terciptanya keadaan yang baik tersebut. Namun keinginan itu belum terlaksana dengan baik, dikarenakan kurangnya tenaga ahli. Lantas bagaimana kekristenan memandang hal ini. Tentunya akan timbul pertanyaan juga apa yang harus dilakukan untuk membawa warga binaan dari hidup yang salah menuju arah yang benar. Tentu saja dengan membina spiritualitas mereka dan tentunya mengajarkan kepada mereka spiritualitas Kristen.
Edukasi Konstruktif Terhadap Fenomena LGBTQ Menurut Perspektif Teologi Kristen
Authors: Paat Vicky BGD , Simanjuntak Irfan Feriando , Siahaan Harls Evan R. 
Published: March 2022

LGBTQ is a fact of existence so it cannot be considered as an issue only. LGBTQ is not just a problem to be addressed so that it becomes a pro or con in society, including Christians, because LGBTQ is not a "rumor" or hearsay. LGBTQ is a fact or reality that exists in society. What is the Bible's answer about LGBTQ in 1 Corinthians 6:9-11, Paul states Don't be misguided! The fornicator, ... the adulteress, the effeminate, the sorcerer ... will not inherit the kingdom of God. The verb “ἦτε” (ēte) in verse 11 confirms that in the Corinthian church there were people called “οὔτε μοιχοί, οὔτε μαλακοί, οὔτε ἀρσενοκοῖται” (oute moikhi, oute malakoi, oute arsenokoitai). The word that is often debated is “ἀρσενοκοῖται” (arsenokoitai). “arsenokoitai, can refer to a grown man who has a slave who is used as a sexual partner to fulfill his lust, so clearly this is a sin that requires church ministry as an expression of Christ's love that they need the true gospel that saves. Through this discussion, I judge for us to return to the gospel which is the power of God that saves every believer! That is the gospel that makes the arsenokoitai give themselves to be sanctified and become people who are sanctified and justified in the name of the Lord Jesus Christ. AbstrakLGBTQ merupakan sebuah fakta keberadaannya sehingga tidak bisa dianggap sebagai sebuah isu saja. LGBTQ tidak sekedar sebuah masalah untuk ditanggapi sehingga menjadi pro atau kontra di masyarakat termasuk Kristen , karena LGBTQ bukan sebuah sebuah “desas-desus” atau kabar angina.. LGBTQ adalah sebuah sebuah fakta atau kenyataan yang ada di masyarakat. Apakah jawaban Alkitab tentang LGBTQ dalam 1 Korintus 6:9-11, Paulus menyatakan Janganlah sesat! Orang cabul, ... orang berzinah, banci, orang pemburit ... tidak akan mendapat bagian dalam Kerajaan Allah. Kata kerja “ἦτε” (ēte) dalam ayat 11 menegaskan bahwa di jemaat Korintus ada orang yang disebut “οὔτε μοιχοί, οὔτε μαλακοί, οὔτε ἀρσενοκοῖται” (oute moikhi, oute malakoi, oute arsenokoitai). Kata yang sering diperdebatkan adalah “ἀρσενοκοῖται” (arsenokoitai). “arsenokoitai, dapat mengacu ke lelaki dewasa yang memiliki seorang budak yang dijadikan mitra seksualnya dalam melampiaskan nafsu syahwatnya, jadi jelas ini adalah dosa yang membutuhkan pelayanan gereja sebagai wujud kasih Kristus bahwa mereka membutuhkan Injil yang sejati yang menyelamatkan. Melalui diskusi ini saya menyerukan untuk kita kembali kepada Injil yang adalah kekuatan Allah yang menyelamatkan setiap orang yang percaya itu! Itulah Injil yang membuat para arsenokoitai memberi diri mereka disucikan dan menjadi orang-orang yang dikuduskan dan dibenarkan di dalam nama Tuhan Yesus Kristus
Kegiatan Bakti Sosial Pembagian Masker Gratis: Upaya Pencegahan Penyebaran Covid-19 Di Kota Batam
Authors: Tarigan Johannes , Ferry Yusak Hentrias , Togodi Yonatan , Telaumbanua Feberianus 
Published: March 2022

Batam Center Ferry Port is the place where this social service activity is carried out. This port is a gateway for foreigners and Indonesian citizens to go to neighbouring countries. Therefore, the NGO PEDULI BANGSA is moved to help the government through community service activities in collaboration with the Indonesian Journalists Association and the Local Youth Association. The purpose of this service is to help the government to prevent the spread of the Covid-19 outbreak in the city of Batam. The forms and methods of the activities carried out are increasing public awareness about health by distributing free masks in the midst of the scarcity and high price of masks, then conducting counselling on how to use masks correctly. The result of this activity is an increase in public awareness about the importance of preventing the spread of the Covid-19 outbreak by wearing the right masks. AbstrakPelabuhan Ferry Batam Center merupakan tempat kegiatan bakti sosial ini dilaksanakan. Pelabuhan ini merupakan gerbang keluar masuk bagi WNA dan WNI menuju negara tetangga. Oleh karena itu, LSM PEDULI BANGSA tergerak untuk membantu pemerintah melalui kegiatan pengabdian masyarakat dengan bekerja sama dengan Persatuan Wartawan Indonesia dan Persatuan Pemuda Tempatan. Tujuan dari pengabdian ini adalah membantu pemerintah untuk mencegah penyebaran wabah Covid-19 di kota Batam. Bentuk dan metode kegiatan yang dilakukan yaitu peningkatan kesadaran masyarakat tentang kesehatan dengan membagikan masker gratis di tengah-tengah kelangkaan dan mahalnya harga masker, kemudian melakukan penyuluhan cara menggunakan masker yang benar. Hasil dari kegiatan ini adalah peningkatan kesadaran masyarakat tentang pentingnya untuk mencegah penyebaran wabah Covid-19 dengan memakai masker yang benar.
Pendampingan Dan Peningkatan Literasi Siswa Melalui Gerakan Membaca Di Masa Pandemi Di Desa Mentuda Kecamatan Lingga Kabupaten Lingga
Authors: Tafonao Talizaro , Widjaja Fransiskus Irwan , Hutagalung Sabar Manahan , Simanjuntak Haposan , Paat Vicky B. G. D. , Simatupang Sihar Lamhot , Purba Juntriman 
Published: March 2022

The purpose of this service is to maximize children's ability to read and write in Mentuda Village, Lingga Regency while studying at home. The impact of Covid-19 has disrupted the learning system in various schools including children in Mentuda Village. This activity is carried out based on the problems experienced by the children as explained in this article. The method of implementing this community service is lectures, discussions, simulations and practices on how to read correctly. After this activity was carried out, the results obtained were that about 90% of children read well as the results in the explanation in this article. This can be seen in every activity carried out by the children who are very enthusiastic in participating in each session that has been arranged by the team. This means that activities like this are very effective to continue to be carried out for children. AbstrakTujuan pengabdian ini adalah untuk memaksimalkan kemampuan anak dalam baca dan tulis di Desa Mentuda Kecamatan Lingga Kabupaten selama belajar di rumah. Dampak dari Covid-19 ini telah mengganggu sistem belajar di berbagai sekolah termasuk anak-anak yang ada di Desa Mentuda. Kegiatan ini dilakukan berdasarkan masalah yang dialami oleh anak-anak sebagaimana penjelasan dalam artikel ini. Metode pelaksanaan pengabdian masyarakat ini yakni ceramah, diskusi, simulasi dan praktik tentang cara membaca yang benar. Setelah kegiatan ini dilakukan, hasil yang dapatkan adalah anak-anak membaca dengan baik sekitar 90% sebagaimana hasil dalam penjelasan dalam artikel ini. Hal ini nampak pada setiap kegaitan yang dilakukan anak-anak sangat antusias dalam mengikuti setiap sesi yang telah diatur oleh tim. Artinya bahwa kegiatan-kegiatan seperti ini sangat efektif untuk terus dilakukan kepada anak-anak.
Website Profil Satuan Polisi Pamong Praja dan Pemadam Kebakaran Kabupaten Banggai
Authors: Sahidu Heriyanto 
Published: March 2022

Polisi Pamong Praja dan Pemadam Kebakaran sampai saat ini dengan berbagai masalah yang dapat teridentifikasi tersebut alangka baiknya di lakukan perbaikan terhadap teknologi yang ada. Oleh karena itu penulis mengusulkan untuk membuat website yang mampu memberikan manajemen data yang baik dan mampu memberikan sebuah kemampuan mencari dan menampilkan informasi yang baik sehinggah dibuatlah Website Profil Satuan Polisi Pamong Praja dan Pemadam Kebakaran. Metode penelitian yang digunakan dalam menulis penelitian ini adalah Metode Lapangan/Observasi yaitu pengamatan secara lansung di Lokasi dan bertanya kepada petugas-petugas di Kantor Satpol pp.
Reimbursement for Complex Carpal Trauma
Authors: Dunn John , Scanaliato John , Green Clare , Rhee Peter Charles , Nesti Leon 
Published: March 2022

Objectives: To compare Relative Value Unit (RVU)-based reimbursement of operative fixation of complex carpal trauma versus primary operative fixation of distal radius fractures.
Design: Database review.
Setting: National Surgical Quality Improvement Program (ACS-NSQIP) database
Intervention: Surgical treatment of complex carpal trauma and distal radius fracture.
Main outcome measurement: Mean and median total work Relative Value Unit (wRVU), surgical time, wRVU/minute, reimbursement/minute, reimbursement/surgical case.
Results: The 139 patients who underwent fixation of complex carpal trauma and 222 patients who underwent fixation of distal radius fractures were included in this study. The mean wRVUs were 10.56 for the complex carpal trauma group and 12.46 for the distal radius fracture group. Complex carpal trauma cases were an average of 31 minutes longer than distal radius fracture cases. Mean wRVU/minute (0.19 vs 0.14) and median wRVU/minute (0.18 vs 0.11) were higher for distal radius fracture cases than for complex carpal trauma cases (percent difference: mean 34%, median 62%). Lastly, the mean ($378.85) and median reimbursement ($383.29) per surgical case for complex carpal trauma was lower than that of the mean ($447.19) and median reimbursement ($516.08) of distal radius fractures.

Conclusions: Despite longer operative times and increased procedural complexity, surgical treatment of complex carpal trauma is reimbursed significantly less than surgical treatment of distal radius fractures. The authors advocate a threefold plan. First, the ACS may consider developing more clear guidelines on the definition of a hand surgeon. Second, hand surgeons must insert themselves into hospital policy making, particularly with call and consult management discussions. Finally, considering the three components of the RVU calculation (physician work, physician expertise, and liability), the management of complex carpal trauma is under-recognized and reimbursed. As such, the authors recommend consideration of these injuries to be recompensed commiserate with arthroplasty and orthopaedic trauma.
Level of Evidence: IV; Economic Analysis
Keywords: Complex carpal trauma, relative value unit, wRVU, reimbursement, distal radius fracture
(J Ortho Business 2022; Volume 1, Issue 1:pages 19-23)
Horizontal and Vertical Diversification of Specializations in Home gardens: A Case Study of Thruvanathapuram District of Kerala
Authors: Sreelakshmi C. , Thomas Allan 
Published: March 2022

Aim: To delineate extent of horizontal cum vertical integrations and to analyze distribution of specializations based on the level of vertical diversification
Study Design: ‘Ex-post-facto’ and ‘explorative’ research designs were used for conducting the present study.
Place and Duration of Study: The study was conducted in Thruvanathapuram district of Kerala in India during 2018-2020.
Methodology: Specialized homegardens identified under ‘ICAR Niche Area Excellence project’ were selected for the study. Sixty specialised homegardens with twelve homegardens each from each AEUs were selected for data enumeration.
Results: Majority of specialized homegardens (60%) do have more than 4 tiers/levels of horizontal diversification whereas 40% have less than 4 tiers of diversification. Similarly, distribution of vertical diversification shows that 61.6% have less than 3 levels and 38.3 % have more than 3 levels of vertical diversification. Mean vertical diversification was found to be highest for livestock-cow (3.75) and least was for tubers and orchids (1) each. However 3 levels of vertical diversification was noticed for rubber, animal husbandry, coconut, goat, mushroom and aquaculture.
Conclusion: Homegardens with specializations are the sustainable production system. If the competent authorities pay attention to the individual specializations of the system and give adequate thrust to the value addition of these specializations, then definitely homegardens can turn out to be better remunerative farming system fetching supplementary benefits.
Role of Arbitration in Resolving Medical Malpractices : A Literature Review
Authors: Kusuma Agus Perry , Isworo Slamet 
Published: March 2022

Background and Objective: Most malpractice disputes are caused by the breakdown of communication between patients and doctors or hospitals, which can harm the reputation of both parties, necessitating a fair solution. Cases can be resolved in one of two ways: litigation or non- litigation. Arbitration is a non-litigation method to reach a fair settlement without involving a court. The aim of the literature review is to describe the role of arbitration in the settlement of malpractice cases.
Methods: This study uses a systematic literature review.
Results: Arbitration is a reasonable method for resolving malpractice claims. This can be done by optimizing the rule of law in the form of pre-contract agreements between patients and hospitals or doctors, and by using the Arbitration Board to resolve medical disputes, especially malpractice disputes before they become court cases.
Conclusion: The significance of maximizing the rule of law as a foundation for carrying out an arbitration pattern is that it is faster and less expensive, and the decision is final and binding.
Synthesis and Characterization of Mesoporous Carbon Supported Ni-Ga Catalyst for Low-Pressure CO2 Hydrogenation
Authors: Sofyani Uwin , Krisnandi Yuni Krisyuningsih , Abdullah Iman 
Published: March 2022

In this study, the atmospheric-pressure hydrogenation of CO2 was carried over bimetallic Ni-Ga catalyst supported on mesoporous carbon (MC). MC was successfully prepared using the soft-template method as proven by Fourier Transform Infra Red (FTIR), X-ray Diffraction (XRD), Scanning Electron Microscopy - Energy Dispersive X-Ray Spectroscopy (SEM-EDS), Brunauer–Emmett–Teller Surface Area Analyzer (BET SAA), and Transmission Electron Microscopy (TEM) characterizations. The Ni-Ga/MC catalyst was synthesized using the impregnation method, and based on the XRD characterization, the formation of bimetallic Ni-Ga on the MC support is confirmed. The EDS mapping image shows the uniform distribution of the bimetallic Ni-Ga on the MC surface, especially for the Ni5Ga3/MC and NiGa3/MC catalysts. Moreover, the TEM images show an excellent pore size distribution. The formation of Ni-Ga alloy was identified as an active site in the CO2 hydrogenation. Ni5Ga3/MC catalyst exhibited a 10.80% conversion of CO2 with 588 μmol/g formaldehyde at 1 atm, 200 °C, and H2/CO2 ratio of 3/1. Copyright © 2022 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).
Rational Synthesis of Solid‐State Ultraviolet B Emitting Carbon Dots via Acetic Acid‐Promoted Fractions of sp3 Bonding Strategy
Authors: Xu Jiahui , Liang Qingjing , Li Zijian , Osipov Vladimir Yu. , Lin Yangjian , Ge Binghui , Xu Qian , Zhu Junfa , Bi Hong 
Published: March 2022

AbstractCarbon dots (CDs) have received tremendous attention for their excellent photoluminescence (PL) properties. However, it remains a great challenge to obtain CDs with ultraviolet (UV, 200–400 nm) emission in solid state, which requires strict control of the CDs structure and overcoming the aggregation‐caused quenching (ACQ). Herein, a new sp3 compartmentalization strategy is developed to meet these requirements, by employing acetic acid to promote fractions of sp3 bonding during the synthesis of CDs. It markedly decreases the size of sp2 conjugating units in the CDs, and shifts PL emission to the ultraviolet B (UVB) region (λmax = 308 nm). Moreover, sp2 domains are well spatially compartmentalized by sp3 domains and the ACQ effect is minimized, enabling the high quantum yield in solid state (20.2%, λex = 265 nm) with a narrow bandwidth of 24 nm and environmental robustness. The solid‐state UVB emissive CDs are highly desired for application in photonic devices. Hence, a demo of UVB light‐emitting diodes is fabricated for plant lighting, leading to a 29% increase of ascorbic acid content in the basil. Overall, a rational and efficient way to construct solid UVB‐CDs phosphors for wide applications is provided.