bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of polycystic ovary syndrome and postmenopausal osteoporosis by inhibiting apoptosis with Shenling Baizhu powder compound
Authors: Liang Jing , Bao Ai-li , Ma Hong-yu , Dong Wei , Li Wei-hua , Wu Xi , Li Han-yu , Hou Hai-yan , Chen Ya-qiong , Fu Jia-lin , Shao Chao 
Published: October 2022

Objective
Shenling Baizhu powder (SBP) has been shown to reverse the abnormal expression of the aromatic hydrocarbon receptor (AHR) mediated by air pollution. Our study aimed to understand the main ingredient of SBP and investigate its action mechanism in preventing polycystic ovary syndrome (POCS) and postmenopausal osteoporosis (PMO).

Methods
The active ingredients of SBP with the highest binding affinity to AHR were screened using a Chinese medicine database, and their binding mechanism was simulated using molecular dynamics simulation (MDS). Rutin was utilized to treat ovarian granulosa cell lines and osteoblast cell lines. The cell lines were treated with a gradient of rutin concentration (0.01 mmol/L, 0.05 mmol/L and 0.1 mmol/L) to find the optimal drug dose. PCR was used to detect AHR and apoptosis-related proteins, and WB to detect the expression of AHR, caspase-3 and cleaved-caspase-3. Finally, the CCK-8 cell proliferation assay detected the proliferation of cells.

Results
We obtained Rutin through the Chinese medicine database, and dynamics simulation determined its binding sites. Ovarian granulosa cell lines and osteoblast cell lines were treated with Rutin. RT-PCR and western blotting revealed that the expression of apoptosis-associated protein Bcl-2 was elevated, and the expression of AHR, Bax, caspase-3 and PARP were decreased. CCK-8 results showed accelerated proliferation in both cell types.

Conclusion
Rutin, the main ingredient of SBP compound, works by binding to AHR, which can improve POCS and PMO by inhibiting cell apoptosis and by promoting cell proliferation.
A Scrutiny of Diverse Parameters and Post Tracheostomy Outcome with Quality of Life in Severe COVID-19 Infection
Authors: Emmanuel Ria , Anoopa M. V. , Kumari A. M. Anitha 
Published: October 2022

Objectives: The primary aim was to investigate the prognostic factors among critically ill COVID-19 patients, who required mechanical ventilation and tracheostomy. Secondary aim was to analyse their Health-related Quality of Life (HrQoL) at 90 days after ICU discharge.
Study Design & Setting: An observational cohort study conducted at a quaternary care setting in Bengaluru, India.
Patients’ demographics and clinical data including inflammatory markers, ventilatory parameters, details of intubation and tracheostomy were analysed.
Methods: Data were analysed and expressed as mean with percentage (%). Data from the 2 groups, survivors and non- survivors, were compared using Fisher's exact test for categorical variables and t test for continuous variables. The survivors and ‘age and sex’ - matched general population (not infected by COVID-19), from the same geographical area were subjected to questionnaires by the EuroQol group.
Results: Among 33 critically ill COVID-19 patients who underwent tracheostomy,15 patients (45.4%) survived. Comorbidities and COVID-19 related complications were noted high among the non-survivors. Ventilatory parameters FiO2, PEEP and PaO2/FiO2 were better in the survivors group which favored the recovery. Complication rate of tracheostomy was 18.1%.Ventilation liberation rate from our study was found to be 45.4% and decannulation rate 42.4%. Low values of D-Dimer and Ferritin strongly favored better recovery. Health-related Quality of Life of the survivor group and general population were comparable.
Conclusion: Ventilatory parameters, inflammatory markers and comorbidities do have a role in prognosticating outcome in patients who required tracheostomy. At 90 days follow up there was no significant impact of the disease in the quality of life of survivors.
A Missed Periorbital Foreign Body
Authors: Suman Suwarna , Kumar Arushi , Rathod Hemant Uttamrao , Pal Virendra K. 
Published: October 2022

Trauma involving the eye, orbital and periorbital regions are commonly seen in cases of road traffic accidents, sports injuries and physical assaults, but cases of intraorbital / periorbital foreign bodies are rare. Early presentation, history of trauma, and imaging help in diagnosis. However, sometimes the diagnosis is missed, particularly in cases with late presentation and a vague history of minor trauma and trauma with a non-metallic foreign body. A missed foreign body may present later with infection, repeated inflammation, ptosis, and proptosis and motility defect, further complicating the management.
Here, we present a case of missed foreign body during the primary repair of facial injury in a 32-year male with polytrauma sustained in a road traffic accident. Evidence of foreign body was reported in a CT scan head advised for head injury. Re-exploration of wound and removal of foreign body is performed under local anaesthesia.
Prototype Stasiun Pengisian Daya Ponsel Seluler Mengunakan Solar Panel 20Wp
Authors: Hamidin Muhammad , Abdillah Hamid , Ramdani Sulerman Deni 
Published: October 2022

Pemanfaatan energi surya di Indonesia merupakan salah satu pilihan dengan potensi terbesar bagi pembangunan negara Indonesia.Energi listrik yang paling besar untuk dipakai untuk menjadi energi yakni sinar matahari. Tujuan Penelitian ini adalah untuk menguji coba alat stasiun pengisian daya ponsel menggunakan solar panel dengan meneliti besaran arus yang diukur selama 3 hari berturut-turut serta proses pengecasannya, metode yang digunakan dalam penelitian yakni metode penelitian terapan. Analisis data diperoleh arus input panel surya ke SCC sebesar 11,6V pada hari pertama, 12,8V hari kedua dan 12,6V pada hari ketiga berdasarkan data yang diambil kondisi cuaca sangat mempengaruhi besaran input arus yang didistribusikan ke Solar Charge Control (SCC), Pada saat pengisian daya dari baterai ke modul lalu ke ponsel dari 60-100% memerlukan waktu 40 menit dalam proses pengisian dayanya karena meng­gunakan baterai polimer 20.000 Mah maka dapat mengecas Ponsel Sebanyak 4 kali dengan ketahanan baterai yang baik saat pengisian pun dapat mengecas 2 ponsel.
Enhancing Electron Correlation at a 3d Ferromagnetic Surface
Authors: Janas David Maximilian , Droghetti Andrea , Ponzoni Stefano , Cojocariu Iulia , Jugovac Matteo , Feyer Vitaliy , Radonjić Miloš M. , Rungger Ivan , Chioncel Liviu , Zamborlini Giovanni , Cinchetti Mirko 
Published: October 2022

AbstractSpin‐resolved momentum microscopy and theoretical calculations are combined beyond the one‐electron approximation to unveil the spin‐dependent electronic structure of the interface formed between iron (Fe) and an ordered oxygen (O) atomic layer, and an adsorbate‐induced enhancement of electronic correlations is found. It is demonstrated that this enhancement is responsible for a drastic narrowing of the Fe d‐bands close to the Fermi energy (EF) and a reduction of the exchange splitting, which is not accounted for in the Stoner picture of ferromagnetism. In addition, correlation leads to a significant spin‐dependent broadening of the electronic bands at higher binding energies and their merging with satellite features, which are manifestations of a pure many‐electron behavior. Overall, adatom adsorption can be used to vary the material parameters of transition metal surfaces to access different intermediate electronic correlated regimes, which will otherwise not be accessible. The results show that the concepts developed to understand the physics and chemistry of adsorbate–metal interfaces, relevant for a variety of research areas, from spintronics to catalysis, need to be reconsidered with many‐particle effects being of utmost importance. These may affect chemisorption energy, spin transport, magnetic order, and even play a key role in the emergence of ferromagnetism at interfaces between non‐magnetic systems.
Advances in Solution‐Processed OLEDs and their Prospects for Use in Displays
Authors: Woo Joo Yoon , Park Min‐Ho , Jeong Su‐Hun , Kim Young‐Hoon , Kim Byungjae , Lee Tae‐Woo , Han Tae‐Hee 
Published: October 2022

AbstractThis review outlines problems and progress in development of solution‐processed organic light‐emitting diodes (SOLEDs) in industry and academia. Solution processing has several advantages such as low consumption of materials, low‐cost processing, and large‐area manufacturing. However, use of a solution process entails complications, such as the need for solvent resistivity and solution‐processable materials, and yields SOLEDs that have limited luminous efficiency, severe roll‐off characteristics, and short lifetime compared to OLEDs fabricated using thermal evaporation. These demerits impede production of practical SOLED displays. This review outlines the industrial demands for commercial SOLEDs and the current status of SOLED development in industries and academia, and presents research guidelines for the development of SOLEDs that have high efficiency, long lifetime, and good processability to achieve commercialization.
A Janus Au–Polymersome Heterostructure with Near‐Field Enhancement Effect for Implant‐Associated Infection Phototherapy
Authors: Chen Chuanshuang , Chu Guangyu , He Wanting , Liu Yannan , Dai Kai , Valdez Jesus , Moores Audrey , Huang Pei , Wang Zhaohong , Jin Jiale , Guan Ming , Jiang Wenfeng , Mai Yiyong , Ma Dongling , Wang Yue , Zhou Yongfeng 
Published: October 2022

AbstractPolymer–inorganic hybrid Janus nanoparticles (PI‐JNPs) have attracted extensive attention due to their special structures and functions. However, achieving the synergistic enhancement of photochemical activity between polymer and inorganic moieties in PI‐JNPs remains challenging. Herein, the construction of a novel Janus Au–porphyrin polymersome (J‐AuPPS) heterostructure by a facile one‐step photocatalytic synthesis is reported. The near‐field enhancement (NFE) effect between porphyrin polymersome (PPS) and Au nanoparticles in J‐AuPPS is achieved to enhance its near‐infrared (NIR) light absorption and electric/thermal field intensity at their interface, which improves the energy transfer and energetic charge‐carrier generation. Therefore, J‐AuPPS shows a higher NIR‐activated photothermal conversion efficiency (48.4%) and generates more singlet oxygen compared with non‐Janus core–particle Au–PPS nanostructure (28.4%). As a result, J‐AuPPS exhibits excellent dual‐mode (photothermal/photodynamic) antibacterial and anti‐biofilm performance, thereby significantly enhancing the in vivo therapeutic effect in an implant‐associated‐infection rat model. This work is believed to motivate the rational design of advanced hybrid JNPs with desirable NFE effect and further extend their biological applications.
Disparities in food insecurity among Black and White households: An analysis by age cohort, poverty, education, and home ownership
Authors: Berning Joshua , Bonanno Alessandro , Cleary Rebecca 
Published: October 2022

AbstractWe use the Current Population Survey's Food Security Supplement data to investigate food insecurity disparities among Black and White households across different age groups and socioeconomic characteristics. We find that disparities in the probability of food insecurity between Black and White households vary considerably across specific socioeconomic strata, in particular education, poverty status, and home ownership. Black households are systematically more food insecure than White, even when conditioning on other attributes, and even once household heterogeneity is eliminated. Thus, factors beyond socioeconomic characteristics may be more important in determining food insecurity disparities across Black and White households.
Ammonia Synthesis at Room Temperature and Atmospheric Pressure from N2: A Boron‐Radical Approach
Authors: Bennaamane Soukaina , Rialland Barbara , Khrouz Lhoussain , Fustier‐Boutignon Marie , Bucher Christophe , Clot Eric , Mézailles Nicolas 
Published: October 2022

AbstractAmmonia, NH3, is an essential molecule, being part of fertilizers. It is currently synthesized via the Haber–Bosch process, from the very stable dinitrogen molecule, N2 and dihydrogen, H2. This process requires high temperatures and pressures, thereby generating ca 1.6 % of the global CO2 emissions. Alternative strategies are needed to realize the functionalization of N2 to NH3 under mild conditions. Here, we show that boron‐centered radicals provide a means of activating N2 at room temperature and atmospheric pressure whilst allowing a radical process to occur, leading to the production of borylamines. Subsequent hydrolysis released NH4+, the acidic form of NH3. EPR spectroscopy supported the intermediacy of radicals in the process, corroborated by DFT calculations, which rationalized the mechanism of the N2 functionalization by R2B radicals.
Unveiling the Protonation Kinetics‐Dependent Selectivity in Nitrogen Electroreduction: Achieving 75.05 % Selectivity
Authors: Liu Yang , Wang Lingling , Chen Lin , Wang Hongdan , Jadhav Amol R. , Yang Taehun , Wang Yixuan , Zhang Jinqiang , Kumar Ashwani , Lee Jinsun , Bui Viet Q. , Kim Min Gyu , Lee Hyoyoung 
Published: October 2022

AbstractWhile higher selectivity of nitrogen reduction reaction (NRR) to ammonia (NH3) is always achieved in alkali, the selectivity dependence on nitrogen (N2) protonation and mechanisms therein are unrevealed. Herein, we profile how the NRR selectivity theoretically relies upon the first protonation that is collectively regulated by proton (H) abundance and adsorption‐desorption, along with intermediate‐*NNH formation. By incorporating electronic metal modulators (M=Co, Ni, Cu, Zn) in nitrogenase‐imitated model‐iron polysulfide (FeSx), a series of FeMSx catalysts with tailorable protonation kinetics are obtained. The key intermediates behaviors traced by in situ FT‐IR and Raman spectroscopy and operando electrochemical impedance spectroscopy demonstrate the strong protonation kinetics‐dependent selectivity that mathematically follows a log‐linear Bradley curve. Strikingly, FeCuSx exhibits a record‐high selectivity of 75.05 % at −0.1 V (vs. RHE) for NH3 production in 0.1 M KOH electrolyte.
A Carbon Nanotube Binding BODIPY‐C60 Nano Tweezer: Charge Stabilization through Sequential Electron Transfer
Authors: Kazemi Shahrzad , Jang Youngwoo , Liyanage Anuradha , Karr Paul A. , D'Souza Francis 
Published: October 2022

AbstractElectron donor–acceptor (DA) hybrids comprised of single‐wall carbon nanotubes (SWCNTs) are promising functional materials for light energy conversion. However, the DA hybrids built on SWCNTs have failed to reveal the much‐sought long‐lived charge separation (CS) due to the close proximity of the DA entities facilitating charge recombination. Here, we address this issue and report an elegant strategy to build multi‐modular DA hybrids capable of producing long‐lived CS states. For this, a nano tweezer featuring V‐shape configured BODIPY was synthesized to host SWCNTs of different diameters via π‐stacking. Supported by spectral, electrochemical, and computational studies, the established energy scheme revealed the possibility of sequential electron transfer. Systematic pump‐probe studies covering wide spatial and temporal scales provided evidence of CS from the initial 1BODIPY* ultimately resulting in C60⋅−‐BODIPY‐SWCNT⋅+ CS states of lifetimes in the 20‐microsecond range.
Fluorinated Tetraarylethenes: Universal Tags for the Synthesis of Solid State Luminogens
Authors: Suleymanov Abdusalom A. , Kraus Barbara M. , Damiens Thibault , Ruggi Albert , Solari Euro , Scopelliti Rosario , Fadaei‐Tirani Farzaneh , Severin Kay 
Published: October 2022

AbstractThe aggregation‐induced emission properties of tetraarylethenes (TAEs) have led to numerous applications in chemistry, biology, and materials science. Herein, we describe two fluorinated tetraarylethenes, which can be employed as universal tags for the synthesis of solid state luminogens. The tags are accessible in one or two steps from commercially available starting materials. Facile coupling reactions with ubiquitous substrates such as thiols, alcohols, amines, phosphines, aldehydes, and enamines allow preparing a wide range of TAE conjugates, including tagged amino acids, peptides, carbohydrates, steroids, and commercial polymers.
Nickel‐Catalyzed Enantioconvergent Carboxylation Enabled by a Chiral 2,2′‐Bipyridine Ligand
Authors: Wang Linghua , Li Tao , Perveen Saima , Zhang Shuai , Wang Xicheng , Ouyang Yizhao , Li Pengfei 
Published: October 2022

AbstractIn contrast to previous approaches to chiral α‐aryl carboxylic acids that based on reactions using hazardous gases, pressurized setup and mostly noble metal catalysts, in this work, a nickel‐catalyzed general, efficient and highly enantioselective carboxylation reaction of racemic benzylic (pseudo)halides under mild conditions using atmospheric CO2has been developed. A unique chiral 2,2′‐bipyridine ligand named Me‐SBpy featuring compact polycyclic skeleton enabled both high reactivity and stereoselectivity. The utility of this method has been demonstrated by synthesis of various chiral α‐aryl carboxylic acids (30 examples, up to 95 % yield and 99 : 1 er), including profen family anti‐inflammatory drugs and transformations using the acids as key intermediates. Based on mechanistic experimental results, a plausible catalytic cycle involving Ni‐complex/radical equilibrium and Lewis acid‐assisted CO2activation has been proposed.
Four‐Component Strain‐Release‐Driven Synthesis of Functionalized Azetidines
Authors: Tyler Jasper L. , Noble Adam , Aggarwal Varinder K. 
Published: October 2022

AbstractDespite the favorable properties that azetidine rings can engender on drug‐compounds, methods for the diversity‐oriented synthesis of azetidine‐based structures are significantly underdeveloped. Herein, we report the successful realization of a multicomponent [1,2]‐Brook rearrangement/strain‐release‐driven anion relay sequence and its application to the modular synthesis of substituted azetidines. The rapidity of the reaction, as confirmed by in situ infra‐red spectroscopy, leverages the strain‐release ring‐opening of azabicyclo[1.1.0]butane to drive the equilibrium of the Brook rearrangement. The three electrophilic coupling partners, added sequentially to azabicyclo[1.1.0]butyl‐lithium, could be individually varied to access a diverse compound library. The utility of this methodology was demonstrated in a 4‐step synthesis of the EP2 receptor antagonist PF‐04418948.
A Carboranyl Electrolyte Enabling Highly Reversible Sodium Metal Anodes via a “Fluorine‐Free” SEI
Authors: Tomich Anton W. , Park Jehee , Son Seoung‐Bum , Kamphaus Ethan P. , Lyu Xingyi , Dogan Fulya , Carta Veronica , Gim Jihyeon , Li Tao , Cheng Lei , Lee Eungje , Lavallo Vincent , Johnson Christopher S. 
Published: October 2022

AbstractRealization of practical sodium metal batteries (SMBs) is hindered due to lack of compatible electrolyte components, dendrite propagation, and poor understanding of anodic interphasial chemistries. Chemically robust liquid electrolytes that facilitate both favorable sodium metal deposition and a stable solid‐electrolyte interphase (SEI) are ideal to enable sodium metal and anode‐free cells. Herein we present advanced characterization of a novel fluorine‐free electrolyte utilizing the [HCB11H11]1− anion. Symmetrical Na cells operated with this electrolyte exhibit a remarkably low overpotential of 0.032 V at a current density of 2.0 mA cm−2 and a high coulombic efficiency of 99.5 % in half‐cell configurations. Surface characterization of electrodes post‐operation reveals the absence of dendritic sodium nucleation and a surprisingly stable fluorine‐free SEI. Furthermore, weak ion‐pairing is identified as key towards the successful development of fluorine‐free sodium electrolytes.
Cesium Amide‐Catalyzed Selective Deuteration of Benzylic C‐H Bonds with D2 and Application for Tritiation of Pharmaceuticals
Authors: Du Hui‐Zhen , Fan Jun‐Zhen , Wang Zhong‐Zhen , Strotman Neil A. , Yang Haifeng , Guan Bing‐Tao 
Published: October 2022

AbstractHydrogen isotope exchange (HIE) represents one of the most attractive labeling methods to synthesize deuterium‐ and tritium‐labeled compounds. Catalytic HIE methods that enable site‐selective C−H bond activation and exchange labeling with gaseous isotopes D2 and T2 are of vital importance, in particular for high‐specific‐activity tritiation of pharmaceuticals. As part of our interest in exploring s‐block metals for catalytic transformations, we found CsN(SiMe3)2 to be an efficient catalyst for selective HIE of benzylic C−H bonds with D2 gas. The reaction proceeds through a kinetic deprotonative equilibrium that establishes an exchange pathway between C−H bonds and D2 gas. By virtue of multiple C−H bonds activation and high activity (isotope enrichment up to 99 %), the simple cesium amide catalyst provided a very powerful and practically convenient labeling protocol for synthesis of highly deuterated compounds and high‐specific‐activity tritiation of pharmaceuticals.
Strategies for Safely Maintaining Surgical Volume During the COVID‐19 Pandemic: A Mixed‐Methods Study
Authors: Kinch Jill S. , Isenberg Kim , Vaughn Lexie , Shultz Barbara , Upperman Jeffrey S. 
Published: October 2022

ABSTRACTResuming elective surgeries that were canceled during the COVID‐19 pandemic necessitated a change to preprocedure patient preparation at a pediatric tertiary care center in middle Tennessee. We conducted a prospective, observational, mixed‐methods study to determine the effectiveness of a preprocedure COVID‐19 testing team to prevent COVID‐19–related cancellations among pediatric patients receiving planned anesthesia. The intervention involved family member and patient education and a change in health record reporting to include COVID‐19 test results. A team tasked with follow‐up reviewed test results, consulted with families, and coordinated the administration of rapid tests if necessary. We compared preimplementation and postimplementation cancellation rates in four procedural areas and found no significant difference in the cancellation or rescheduling rates (P = .89, 95% confidence interval = –4.29 to 3.09). The team‐based intervention was associated with the preservation of low procedural cancellation rates by mitigating barriers to preprocedural testing.
Curing behavior, mechanical, and flame‐retardant properties of epoxy‐based composites filled by expandable graphite and ammonium polyphosphate
Authors: Yuan Zhi‐Gang , Shu Zhao‐Hui , Qi Liang , Cai Wan‐An , Liu Wen‐Bin , Wang Jun , Derradji Mehdi , Wang Yan‐hui 
Published: October 2022

AbstractIn this study, 4,4′‐Diaminodiphenyl methane (DDM) was exploited as hardener for diglycidyl ether of daidzein (DGED) and epoxy resin mixture (E‐D). The composites were produced by blending with different contents of ammonium polyphosphate (APP) and expandable graphite (EG) into E‐D resin, named E‐D/A‐E composites. Firstly, E‐D/A‐E blends were analyzed by Fourier transform infrared spectroscopy and DSC to evaluate their curing behavior. The TGA was performed on the E‐D/A‐E composites to analyze their thermal stability, and the thermal properties of the composites were enhanced by adding APP‐EG (A‐E) flame retardants. The mechanical properties and the fractured surfaces of the E‐D/A‐E composites were studied by tensile, impact tests and scanning electron microscopy. Finally, through torch burning test, limiting oxygen index (LOI), vertical burning (UL‐94) and micro‐calorimetry tests, the influence of A‐E flame retardants contents on flammability of composites were evaluated. The results showed that the UL‐94 V‐0 rating was obtained for the E‐D/A‐E composites and the composites exhibited a self‐extinguishing phenomenon. When A‐E flame retardants content reached 9.1 wt%, the LOI value reached 34.5%, and total heat release (Total HR) was reduced by 20.2% compared with E‐D/A‐E 1.