bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-Situ Formation of Co Particles Encapsulated by Graphene Layers
Authors: Lee Minjeong , Kim Gyutae , Jeong Gyu Hyun , Yoon Aram , Lee Zonghoon , Ryu Gyeong Hee 
Published: May 2022

Abstract
The process of encapsulating cobalt nanoparticles using graphene layers is mainly direct pyrolysis. The encapsulation structure of hybrids prepared in this way improves the catalyst stability, which greatly reduces the leaching of non-metals and prevents metal nanoparticles from growing beyond a certain size. In this study, cobalt particles surrounded by graphene layers were formed by increasing the temperature in a transmission electron microscope, and they were analyzed using scanning transmission electron microscopy (STEM). Synthesized cobalt hydroxide nanosheets were used to obtain cobalt particles using an in-situ heating holder inside a TEM column. The cobalt nanoparticles are surrounded by layers of graphene, and the number of layers increases as the temperature increases. The interlayer spacing of the graphene layers was also investigated using atomic imaging. The success achieved in the encapsulation of metallic nanoparticles in graphene layers paves the way for the design of highly active and reusable heterogeneous catalysts for more challenging molecules.
Capillary phenomena between plates from statics to dynamics under microgravity
Authors: Chen Shangtong , Duan Li , Kang Qi , Li Wen 
Published: May 2022

Abstract
Plate type surface tension tanks have been widely used in satellites. Capillary phenomena between plates is a important of liquid behaviour in space. Capillary phenomena between plates with varying width and distance under microgravity are analyzed in detail in this paper. A second-order differential equation for the meniscus height is derived and it can be solved by using the fourth-order Runge-Kutta method. To ensure the model’s accuracy during the entire flow process, the influences of the dynamic angle, the friction force, the convective pressure loss and the liquid meniscus in the reservoir are all considered. For a long time period of flow, the convective pressure loss can be neglected and the equation is simplified. This equation is valid for flows between plates with small varying aspect ratios. Theoretical results are in good agreement with numerical results. Besides, influences of the variation of width or distance of plates are discussed. The flow speed won’t vary monotonically as the distance between plates varies parabolically. The optimized flow channel is possible to be obtained based on this equation.
Tunable perfect absorber from visible to near-infrared with insensitive properties to incident angle and polarization
Authors: Zhao Yuanhang , Lin Yuchen , Xiong Ying , Li Zizheng , Wang Xiaoyi , Gao Jinsong 
Published: May 2022

Abstract
In this paper, we propose an Insulator-Metal-Insulator-Metal (IMIM) nano-block array structure, which can achieve tunable single-peak and double-peak perfect absorption properties from visible light to near-infrared. Compared with our previous work, this paper additionally points out that due to the coupling effect between SPPs, the original bule-shifted spectrum is converted into red-shifted during the process of changing the thickness ratio of the middle silver nano-block to the SiO2 nano-block. In the design parameter range, two different structural parameters can be found, which the absorption peak is exactly the same, and the short-wave absorption peak position has the characteristics of "on" and "off". Based on the nature of absorption spectrum, it can be applied to optical switches in optical circuits. And this work also provides a new idea for plasma sensors, which has broad application prospects in the fields of filtering and imaging.
Antimicrobial Resistance and Genotypic Variation of Acinetobacter Baumannii in Pediatric Intensive Care Unit: Correlation Analysis of the Broad-Spectrum Antibiotic Use and the Risk of Developing Carbapenem-Resistant Strains
Authors: Zhang Tao , Xu Xiao , Xu Cai-Fang , Bilya Salisu Rabiu , Xu Wei 
Published: May 2022

Abstract
Objective
The study investigated the changes in drug resistance profile and genotypes of Acinetobacter baumannii (Ab) in the Pediatric Intensive Care Unit (PICU), northeast China.
Methods
Data on all Ab strains cultured from clinical isolates between 2012 and 2018 and the usage patterns of broad-spectrum antibiotics during this period were collected retrospectively. These Ab strains were revived and cultured for antimicrobial resistance testing, and the CRAB-related IPM, VIM, OXA-58, OXA-51, OXA-23, and OXA-24 genes were detected by RT–PCR. The test results were analyzed in conjunction with annual antibiotic usage for intergroup comparison.
Results
541 Ab-positive specimens were collected, of which 370 strains were finally included in the study. 184 strains were subjected to genetic analysis. The CRAB strains identified were only sensitive to amikacin, cotrimoxazole, tigecycline, and cephazolin, whereas their resistance rates to the remaining nine antibiotics were higher than 50%. The use of cefepime was gradually reduced from 2014 to 2018, whereas cefotaxime sulbactam and ceftriaxone tazobactam was substitutionally increased. In contrast, the use of carbapenems antibiotics has been maintained at a minimal level. The expression levels of OXA-51 and OXA-23 were significantly higher, and OXA24 gene expression was significantly lower in the CRAB group than the CSAB group.
Conclusion
The detection rate of CRAB in northeastern China from 2012 to 2018 showed an increasing trend each year. The extensive use of the broad-spectrum antibiotic cefepime may be one of the risk factors leading to this high detection rate CRAB. The abnormal expression levels of OXA-51, OXA-23, and OXA24 are all closely related to the development of CRAB, which should be monitored dynamically to detect CRAB strains as early as possible.
Heterogeneous graph neural network for lncRNA-disease association prediction
Authors: Shi Hong , Zhang Xiaomeng , Liu Lin , Tang Lin 
Published: May 2022

Abstract
The computational methods of lncRNA-disease association prediction are effective ways to solve the problem of expensive and time-consuming traditional biological experiments. However, existing methods still have challenges to make full use of network topology information to identify potential associations between lncRNA and disease in multi-source data. In this study, we propose a novel method called HGNNLDA for lncRNA-disease association prediction. First, HGNNLDA constructs a heterogeneous network composed of lncRNA similarity network, lncRNA-disease association network and lncRNA-miRNA association network; Then, on this heterogeneous network, various types of strong correlation neighbors with fixed size are sampled for each node by restart random walk; Next, the embedding information of lncRNA and disease in each lncRNA-disease association pair is obtained by the method of type-based neighbor aggregation and all types combination though heterogeneous graph neural network, in which attention mechanism is introduced considering that different types of neighbors will make different contributions to the prediction of lncRNA-disease association. As a result, the area under the receiver operating characteristic curve(AUC) and the area under the precision-recall curve(AUPR) under 5-fold cross-validation (5FCV) are 0.9786 and 0.8891, respectively. Compared with five state-of-art prediction models, HGNNLDA has better prediction performance. In addition, in two types of case studies, it is further verified that our method can effectively to predict the potential lncRNA-disease associations, and have ability to predict new diseases without any known lncRNAs.
High efficient graphene terahertz modulator with tuning electromagnetically induced transparency like transmission
Authors: Kim Myunghwan , Lee Sun-Goo , Kim Seong-Han , Kang Chul , Kee Chul-Sik , Kim Soeun 
Published: May 2022

Abstract
Graphene-based optical modulators have been widely investigated owing to the high mobility and tunable permittivity of graphene. However, achieving a high modulation depth with low energy consumption is challenging owing to the weak graphene-light interaction. Here, we propose a high-performance graphene-based optical modulator consisting of a photonic crystal structure and a waveguide with graphene that exhibits an electromagnetically-induced-transparency-like (EIT-like) transmission spectrum at terahertz frequency. The high quality-factor (Q-factor) of guiding mode to cause the EIT-like transmission enhances light-graphene interaction, and the designed modulator achieves a high modulation depth of 98% with a very small Fermi level shift of 0.05 eV. The proposed scheme can be utilized in active optical devices that require low power consumption.
Intelligent Hyperspectral Target Detection For Reliable IoV Applications
Authors: Wang Zi-xu , Jin Lizuo 
Published: May 2022

Abstract
In recent years, hyperspectral imagery has played a significant role in IoV (Internet of Vehicles) vision areas such as target acquisition. Researchers are focusing on integrating detection sensors, detection computing units, and communication units into vehicles to expand the scope of target detection technology with hyperspectral imagery. As imaging spectroscopy technology gradually matures, the spectral resolution of captured hyperspectral images is increasing. At the same time, the volume of data is also increasing. As a result, the reliability of IoV applications is challenged. In this paper, an intelligent hyperspectral target detection method based on deep learning network is proposed. The trained network model requires few computational resources and can provide results in a short time. The effectiveness of our method is validated using several public datasets.
Development of a Risk Classifier to Predict Tumor Recurrence and Lenvatinib Benefits in HCC after Liver Transplantation
Authors: Deng Yinan , Yang Jianming , Chen Yewu , Wang Jianfeng , Fu Binsheng , Zhang Tong , Yi Shuhong , Yang Yang 
Published: May 2022

Abstract
Background and AimsCurrent selection tools were not precise enough to predict recurrence of hepatocellular carcinoma(HCC) and benefit of adjuvant Lenvatinib for patients who received liver transplantation (LT) for HCC. Thus,we aim at developing a risk classifer to predict recurrence of HCC and benefit of adjuvant Lenvatinib for those who underwent LT for HCC.MethodsCox proportional hazards regression model was applied to seleted predictors and create the final model in training cohort of 287 patients who have had LT for HCC,which was tested in a internal validation cohort of 72 patients by using C-statistic and net classification index(NRI) compared with the following HCC selection criteria:the Milan criteria(MC),the Up-to-seven criteria and the University of California San Francisco(UCSF) criteria. ResultsWe built a Risk Classifier of South China Cohort (RCOSC) based on the four variables:the maximum diameter plus number of viable tumors,α-fetoprotein(AFP),microvascular invasion(MIV), highest alanine aminotransferase(ALT) in 7 days after LT.In validation analyses,our RCOSC showed good predictive performance (C-statistic, 0.866; 95%CI, 0.833-0.899), and had better prognostic value than MC(NRI, 0.406; P<0.001),UCSF(NRI,0.497; P<0.001), and Up-to-seven (NRI, 0.527;P<0.001).By applying the RCOSC, we were able to accurately categorize patients into high-risk and low-risk group.Further survival analysis revealed that the patients defined as high-risk group might have a better theraputic response to preventive regimen of Lenvatinib after LT for HCC (HR,0.38; 95%CI,0.161-0.871, P=0.018).ConclusionOur RCOSC presented favourable predictive performance for HCC recurrence.It might be capable to sift out patients benefit from adjuvant therapy after LT for HCC,which provide a reliable tool for precise clinical decision-making of HCC patients with LT.
Effect of candesartan treatment on echocardiographic indices of cardiac remodeling in post myocardial infarction patients
Authors: Tezcan Hüseyin , Tunçez Abdullah , Demir Kenan , Altunkeser Bülent Behlül , Aygül Nazif , Yalçın Muhammed Ulvi , Ateş Muhammed Salih , Aydoğan Canan , Polat Onur Can , Toprak Aslıhan Merve 
Published: May 2022

Abstract
Background: Myocardial infarction (MI) has unfavourable effect on structural and functional properties of the myocardium, referred to as cardiac remodeling. Left ventricular (LV) mass, LV mass index (LVMI) and relative wall thickness (RWT) are important predictors of cardiac remodeling. In this study, we investigated the effect of candesartan treatment in comparison with zofenopril treatment on echocardiographic indices of cardiac remodeling in post MI patients. Material and Methods: In this prospective study, patients who underwent successful percutaneous coronary intervention were randomly assigned to a candesartan or zofenopril treatment. After randomization, echocardiographic indices of cardiac remodeling including LV mass, LVMI and RWT were evaluated before the start of treatment along with one month and six month follow ups. Results: According to our study, candesartan group showed significant reduction of estimated LV mass and LVMI at six month follow up visit compared to baseline values (199.53∓38.51 g vs 212.69∓40.82 g ; 99.05 g/m2 (90.00~116.5) vs 106.0 g/m2 (96.0~123.00), p<0.05 respectively). This trend was also observed in zofenopril group during the six month period (201.22∓40.07 g vs 207.52∓41.61 g ; 101.0 g/m2 (92.25~111.75.0) vs 104.50 g/m2 (95.0~116.75), p<0.05 respectively). Although both classes of drugs had favourable effects on post-MI cardiac remodeling, the absolute benefit was more prominent in candesartan group as compared to zofenopril group (p<0.05).Conclusion: Our results suggest that candesartan treatment following MI may potentially be useful in terms of improving post-MI cardiac remodeling.
Preferences Elicited and Respected for Seriously Ill Veterans through Enhanced Decision-Making (PERSIVED): A protocol for an implementation study in the Veterans Health Administration
Authors: Ersek Mary , Sales Anne , Keddem Shimrit , Ayele Roman , Haverhals Leah M , Magid Kate H , Kononowech Jennifer , Murray Andrew , Carpenter Joan G , Foglia Mary Beth , Potter Lucinda , McKenzie Jennifer , Davis Darlene , Levy Cari 
Published: May 2022

Abstract
Background: Empirical evidence supports the use of structured goals of care conversations and documentation of life-sustaining treatment (LST) preferences in durable, accessible and actionable orders to improve the care for people living with serious illness. As the largest integrated healthcare system in the United States, the Veterans Health Administration (VA) provides an excellent environment to test implementation strategies that promote this evidence-based practice. The Preferences Elicited and Respected for Seriously Ill Veterans through Enhanced Decision-Making (PERSIVED) program seeks to improve care outcomes for seriously ill Veterans by supporting efforts to conduct goals of care conversations, systematically document LST preferences, and ensure timely and accurate communication about preferences across VA and non-VA settings. Methods: PERSIVED encompasses two separate but related implementation projects that support the same evidence-based practice. Project 1 will enroll 12 VA Home Based Primary Care (HBPC) programs and Project 2 will enroll six VA Community Nursing Home (CNH) programs. Both projects begin with a pre-implementation phase during which data from diverse stakeholders are gathered to identify barriers and facilitators to adoption of the LST evidence-based practice. This baseline assessment is used to tailor quality improvement activities using audit with feedback and implementation facilitation during the implementation phase. Site champions serve as the lynchpin between the PERSIVED project team and site personnel. PERSIVED teams support site champions through monthly coaching sessions. At the end of implementation, baseline site process maps are updated to reflect new steps and procedures to ensure timely conversations and documentation of treatment preferences. During the sustainability phase, intense engagement with champions ends, at which point champions work independently to maintain and improve processes and outcomes. Ongoing process evaluation, guided by the RE-AIM framework, is used to monitor Reach, Adoption, Implementation and Maintenance outcomes. Effectiveness will be assessed using several endorsed clinical metrics for seriously-ill populations.Discussion: The PERSIVED program aims to prevent potentially burdensome LSTs by consistently eliciting and documenting values, goals, and treatment preferences of seriously ill Veterans. Working with clinical operational partners, we will apply our findings to HBPC and CNH programs throughout the national VA healthcare system during a future scale-out period.
A novel homozygous Tub mutation associated with autosomal recessive retinitis pigmentosa in a consanguineous Chinese family
Authors: Xu Wei , Xu Ming , Yin Qinqin , Liu Chuanyi , Deng Yun , Liu Sulai , He Guiyun 
Published: May 2022

Abstract
Background: Retinitis pigmentosa (RP) is the most common type of inherited retinopathy with at least 69 genes identified thus far. A significant proportion of RP, However, remains genetically unsolved. In this study, the the genetic basis of a Chinese consanguineous family with autosomal recessive retinitis pigmentosa (arRP) was investigated. Methods : Overall ophthalmic examinations, including funduscopy, decimal best-corrected visual acuity (BCVA), axial length and electroretinography (ERG) were performed to confirm the diagnosis of the patients. Genomic DNA from peripheral blood of the proband was subjected to whole exome sequencing (WES). In silico predictions, structural modelling and minigene assays were conducted to evaluate the pathogenicity of the mutant. Results : Four candidate variants, including heterozygous variant in RAX2, RP1 and PITPNM3 and a homozygous variant in Tub , were detected as suspected pathegenic variants. The novel c.1379A > G mutation in Tub , based on sanger sequencing, was remained to be the only candidate variant that co-segregated with RP phenotype in this pedigree. More importantly, the Asn residue at codon 460 of TUB is highly conserved across diverse species from tropicalis to humans. And the homozygous c.1379A > G mutation in Tub was excluded from 118 ethnically matched normal controls. Although minigen assay revealed that this variant of c.1379A>G in Tub did not affect normal splicing in vitro, multiple bioinformatic algorithm predicted that this variant was deleterious. Conclusions : For the first time we reported the identification of a rare homozygous mutant ( c.1379A>G: p.N460S) in Tub in a consanguineous family with arRP, which was probably the pathogenic basis of arRP in this consanguineous family.
Evaluating cardiovascular involvement by echocardiography in patients with antineutrophil cytoplasmic antibodies associated glomerulonephritis
Authors: Wei Zhao-Nan , An Xiao Ning , Xu Jing , Ni Li-Yan , Shi Hao , Shen Ping-Yan , Zhang Wen , Chen Xiao-Nong , Chen Yong-Xi 
Published: May 2022

Abstract
Objective Cardiovascular involvement in patients with antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (AGN) could be asymptomatic but is closely associated with patients’ prognosis. The aim of this study was to evaluate the cardiovascular involvement ﻿using standard echocardiographic measurements and determine echocardiographic predictors for cardiovascular mortality in those patients. MethodsPatients with newly diagnosed AGN from Department of Nephrology, Ruijin Hospital undergoing ﻿transthoracic echocardiography were retrospectively studied. Cox proportional hazards models were used to investigate baseline variables associated with cardiovascular mortalities. Results Of 319 patients enrolled in our study, 221 patients had echocardiographic abnormalities. Valvular abnormalities were the most common presentation of cardiovascular involvement and valvular regurgitation was the most commonly presentation of echocardiographic abnormality. ﻿Patients with echocardiographic abnormalities had more severe renal involvement. And patients with more advanced age and more severe renal involvement had worse cardiovascular outcome. Kaplan-Meier estimator showed a 3.4-time higher risk of cardiovascular mortality in patients with echocardiographic abnormalities than those without (p<0.01). Left ventricular end diastolic volume (LVEDV, HR=1.63, p<0.001), left ventricular end systolic volume (LVESV, HR=1.47, p<0.001) and left ventricular ejection fraction (LVEF, HR=0.72, p<0.05), are independent predictors of cardiovascular mortality. Conclusions Cardiac involvement was prevalent in patients with AGN. LVEDV, LVESV and LVEF assessed by echocardiography at disease onset are independent prognostic factors for cardiovascular mortality in AGN patients. Our results suggest that echocardiography is a sensitive and non-invasive tool to evaluate cardiovascular abnormalities in AGN patients which could be applied to detect those abnormalities in early stages.
Risk factors of in-hospital death in pediatric patients with hemophagocytic lymphohistiocytosis: A case-control study
Authors: Zhang Lijun , Dai Lei , Li Deyuan 
Published: May 2022

Abstract
Background
Early mortality in patients with hemophagocytic lymphohistiocytosis (HLH) remains largely high. The aim of our study was to comprehensively analyze the risk factors for in-hospital death in HLH patients.
Methods
A retrospective case-control study was conducted at West China Second Hospital of Sichuan University from January 2014 to December 2020. All pediatric patients diagnosed with HLH who were hospitalized for more than 24 hours were considered for inclusion. Collect demographic, laboratory, clinical, genetic profile, treatment information, and outcome data from records. Multivariable logistic regression models were used to evaluate the risk factors of in-hospital death.
Results
150 pediatric patients with HLH were enrolled in the study. The median age of patients was 54 months (IQR 25–107) and 94 (62.7%) were men. The median length of hospital stay was 17 days (IQR 8-27.5). The overall in-hospital mortality rate for the cohort was 8%. Multivariable regression analysis showed that hyperlactatemia (OR = 8.018, 95%CI 1.202–53.471, p = 0.032) and CRRT (OR = 7.746, 95%CI 1.258–47.680, p = 0.027) were associated with higher risk of in-hospital mortality.
Conclusions
These data suggest that hyperlactatemia and CRRT use in pediatric patients with HLH were associated with increased in-hospital mortality.