bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post‐ictal diffuse alveolar haemorrhage: clinical profile based on case reports
Authors: You Jee Young , Stoller James 
Published: April 2022

AbstractDiffuse alveolar haemorrhage (DAH) after a generalized tonic–clonic seizure is a rarely described illness likely involving physical disruption of alveolar–capillary interface similar to the mechanism of neurogenic pulmonary oedema. Based on our review of the English literature, only 11 cases have been reported to date. Recognition of this sparsely reported entity is important for optimal management, including avoidance of medications that have been implicated in causing DAH. Current experience with two additional patients with post‐ictal DAH extends the reported experience to 13 and summarizes what is, to our knowledge, the entire experience of such patients reported in the English literature. This case report highlights the key aspects of clinical presentation, radiological and pathological findings, clinical course and management implications with the goal of enhancing awareness of this condition by respiratory clinicians.
Mean‐square strong stability and stabilization of discrete‐time stochastic systems with multiplicative noises
Authors: Yan Zhiguo , Su Fangxu , Gao Zhiwei 
Published: April 2022

AbstractThis article investigates the mean‐square strong stability and stabilization of a discrete‐time stochastic system corrupted by multiplicative noises. First, the definition of the mean‐square (MS) strong stability is addressed to avoid overshoots in system dynamics, and two necessary and sufficient conditions for the MS‐strong stability are derived. Moreover, the relationship between MS‐strong stability and MS‐stability is given. Second, some necessary and sufficient conditions of the MS‐strong stabilization via state feedback (SF) and output feedback are obtained, respectively. Furthermore, analytical expressions of SF controller and static output feedback (SOF) controller are proposed, respectively. Finally, an equivalent design method for SOF controller and dynamic output feedback controller is presented.
Micro‐IDE: A tool platform for generating efficient deployment alternatives based on microservices
Authors: Karabey Aksakallı Işıl , Çelik Turgay , Can Ahmet Burak , Tekinerdoğan Bedir 
Published: April 2022

AbstractMicroservice architecture (MSA) is a paradigm to design and develop scalable distributed applications using loosely coupled, highly cohesive components that can be deployed independently. The applications that realize the MSA may contain thousands of services that together form the overall system. Microservices interact with each other by producing and consuming data. Deploying frequently communicating services to the same physical resource would reduce network utilization, which is vital for reducing costs and improving scalability. Since the physical resources have limited capacity, it is not always possible to deploy communicating services to the same resource. Therefore, automated efficient deployment alternatives need to be generated for MSA in the design phase. To address this problem, we proposed an algorithmic approach to generate efficient microservice deployment configurations to available cloud resources in our previous study. In this study, a tool (Micro‐IDE) has been proposed to realize and evaluate this approach. The Micro‐IDE tool has been validated using a case study inspired by the Spotify application.
Characterization and in‐silico toxicity prediction of the oxidative degradation products of Pimozide
Authors: Chodankar Rahul , Mahajan Anand 
Published: April 2022

AbstractThe investigation's objective was to access the stability of the drug substance Pimozide under the stress conditions specified in the International Conference on Harmonization Q1A(R2) guideline and to separate, identify, and characterize the degradation products by using liquid chromatography‐tandem mass spectrometry studies without isolating them from the reaction mixture. It was observed that the drug was susceptible to oxidative degradation (15% hydrogen peroxide, 48 h, room temperature) forming four novel degradation products while being stable under hydrolytic, Photolytic, and thermal conditions. The separation of the drug and the degradation products was achieved with good resolution on a Phenomenex C18 column (150 mm × 4.6 mm, 5 µm) using gradient elution. The fragmentation pattern constructed from the liquid chromatography‐quadrupole‐time of flight mass spectrometry data was used for structural characterization of the degradation products. Lastly, the in‐silico absorption, distribution, metabolism, excretion, and toxicity properties prediction was performed by using in‐silico tools like the pKCSM webserver, ToxTree, and OSIRIS property explorer. The primary screening through the pKCSM webserver exposed the hepatoxic and the mutagenic potential of Pimozide, 1‐(1‐(4‐(4‐fluorophenyl)‐4‐phenylbutyl) piperidin‐4‐yl)‐1,3‐dihydro‐2H‐benzo[d]imidazol‐2‐one (degradation product 3) and 1‐(4,4‐bis(4‐fluorophenyl)butyl)‐4‐(2‐oxo‐2,3‐dihydro‐1H‐benzo[d]imidazol‐1‐yl)piperidine 1‐oxide (degradation product 5) whereas, 1‐(1‐(4,4‐diphenylbutyl) piperidin‐4‐yl)‐2,3‐dihydro‐1H‐benzo[d]imidazol‐2‐ol (degradation product 1) was predicted to only possess mutagenic potential. Secondary screening for mutagenicity was done by using ToxTree and OSIRIS property explorer.
Integration of all‐printed zinc ion microbattery and glucose sensor toward onsite quick detections
Authors: Jiang Kang , Wen Xi , Deng Yuxian , Zhou Zeyan , Weng Qunhong 
Published: April 2022

AbstractRational design of microsystems and efficient integration of various functional modules that can directly realize the aimed functions are very attractive for portable and onsite practical applications, which is also significant in developing miniaturized and intelligent electronics and equipment. Unlike the conventional electrochemical glucose sensors that always need auxiliary complex systems for power supply, signal processing, and feedbacks, we design an all‐printed glucose sensor integrated with a zinc ion microbattery (ZIMB) as a micropower source for portable and onsite quick glucose detections. The integrated glucose sensor (GS) and ZIMB (iGS‐ZIMB) system possesses a high areal energy density of 247.3 μWh/cm2 and power density of 1193 μW/cm2 and exhibits high sensitivity up to 464.2 μA/mM/cm2, wide linear range of 0.5–6.0 mM, and good reproducibility in glucose detections. Through a simple amplification circuit design, the glucose concentration signals could be displayed within a short response time of 1.6 s without the need of external auxiliary equipment. Such iGS‐ZIMB microsystem has prominent advantages in efficiency and cost and is promising for onsite medical and healthcare applications.
High‐resolution mapping of Yr78, an adult plant resistance gene to wheat stripe rust
Authors: Dang Chen , Zhang Junli , Dubcovsky Jorge 
Published: April 2022

AbstractWheat stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is responsible for significant yield losses worldwide, which can be minimized by the deployment of Pst resistance genes. Yr78 is an adult plant partial‐resistance gene that has remained effective against the post‐2000 virulent Pst races. In this study, we generated a high‐resolution map of Yr78 based on 6,124 segregating chromosomes. We mapped Yr78 within a 0.05‐cM interval on the short arm of chromosome 6B, which corresponds to an 11.16 Mb region between TraesCS6B02G116200 and TraesCS6B02G118000 in the ‘Chinese Spring’ Ref Seq. v1.1 genome. This interval is likely larger because it includes the unassembled NOR‐B2 region, which may have contributed to the low recombination rate detected in this region. The Yr78 candidate region includes 15 genes that were prioritized for future functional studies based on their annotated function and polymorphisms between susceptible and resistant genotypes. Using exome capture data, we identified five major haplotypes in the candidate gene region, with the H1 haplotype associated with Yr78. The H1 haplotype was not detected in tetraploid wheat (Triticum turgidum L.) but was found in ∼30% of the common wheat cultivars (Triticum aestivum L.), suggesting that the associated resistance to stripe rust may have favored the selection of this haplotype. We developed two diagnostic molecular markers for the H1 haplotype that will facilitate the deployment of Yr78 in wheat breeding programs.
Morbid obesity increases death and dropout from the liver transplantation waiting list: A prospective cohort study
Authors: Delacôte Claire , Favre Mathilde , El Amrani Medhi , Ningarhari Massih , Lemaitre Elise , Ntandja‐Wandji Line Carolle , Bauvin Pierre , Boleslawski Emmanuel , Millet Guillaume , Truant Stephanie , Mathurin Philippe , Louvet Alexandre , Canva Valérie , Lebuffe Gilles , Pruvot François René , Dharancy Sébastien , Lassailly Guillaume ,   The French ABM study group
Published: April 2022

AbstractLiver transplant (LT) candidates with a body mass index (BMI) over 40 kg/m2 have lower access to a liver graft without clear explanation. Thus, we studied the impact of obesity on the waiting list (WL) and aimed to explore graft proposals and refusal.MethodData between January 2007 and December 2017 were extracted from the French prospective national database: CRISTAL. Competing risk analyses were performed to evaluate predictors of receiving LT. Competitive events were (1) death/WL removal for disease aggravation or (2) improvement. The link between grade obesity, grafts propositions, and reason for refusal was studied.Results15,184 patients were analysed: 10,813 transplant, 2847 death/dropout for aggravation, 748 redirected for improvement, and 776 censored. Mortality/dropout were higher in BMI over 35 (18% vs. 14% 1 year after listing) than in other candidates. In multivariate analysis, BMI>35, age, hepatic encephalopathy, and ascites were independent predictors of death/dropout. Candidates with a BMI ≥ 35 kg/m2 had reduced access to LT, without differences in graft proposals. However, grafts refusal was more frequent especially for ‘morphological incompatibility’ (14.9% vs. 12.7% p < 0.01).ConclusionBMI over 35 kg/m2 reduces access to LT with increased risk of dropout and mortality. Increased mortality and dropout could be due to a lower access to liver graft secondary to increased graft refusal for morphological incompatibility.
Evaluation of Critical Structural Assemblies
Authors: Azinović Boris , Kilar Vojko , Koren David 
Published: April 2022

AbstractThe chapter presents the proposed evaluation methodology, which includes evaluation from the technical & structural, and environmental & energy-efficiency aspects. All the parameters and the evaluation criteria are described in detail, and guidelines for the design of structural energy-efficient buildings in earthquake-prone areas are provided. The methodology facilitates the separation of details that are more critical from the aspect of earthquake resistance and energy efficiency on the basis of simple engineering approaches.
The University Mission Before, During and After COVID
Authors: Benner Mats , Grant Jonathan , O’Kane Mary 
Published: April 2022

AbstractThis chapter outlines the background and theoretical assumptions of the book: that universities have evolved intertwined with societal development, and that the role of service to society has been ingrained in universities from their onset. The chapter introduces notions of disruption and rupture as characteristic of the university-society relationship, with the pandemic as only one of many instances in history. Finally, the chapter outlines a theory of power within universities to conceptualise how decisions are made and how the interface between universities and their surrounding society evolves.
The Lived Experience of Students During the COVID Pandemic
Authors: Benner Mats , Grant Jonathan , O’Kane Mary 
Published: April 2022

AbstractThis chapter is composed of short recollections of events during the pandemic, in particular how the experience of individual students coalesced with organisational dynamics in universities, and how each of the contributors responded to and was affected by the pandemic, both on a personal and a professional level. In this chapter, the experiences of students are showcased, and how they adapted in their ways of doing studies and relating to one another as a group, and how they aligned societal needs with professional development.
How Teachers and Students Conceive Music Education: Towards Changing Mentalities
Authors: Pérez Echeverría María Puy 
Published: April 2022

AbstractFor some time now Nieves has been pondering and turning things over in her mind about how to give her piano lessons. Although she has several years of experience as a teacher in the conservatory of music and as a pianist, lately she has not been satisfied with her students or the results they are getting from her teaching.
SAPEA: A System for the Analysis of Instrumental Learning and Teaching Practices
Authors: Pozo Juan Ignacio , Pérez Echeverría María Puy , López-Íñiguez Guadalupe , Casas-Mas Amalia 
Published: April 2022

AbstractAs we have just seen in previous chapters, ways of learning and teaching are determined by how teachers and students conceive of their learning and teaching functions: what do they think learning and teaching is? What are the goals they hope to achieve? What must the student do to learn and how can the teacher help them? what should evaluation consist of? etc.
Effective high-throughput isolation of enriched platelets and circulating pro-angiogenic cells to accelerate skin-wound healing
Authors: Erratico Silvia , Belicchi Marzia , Meregalli Mirella , Di Silvestre Dario , Tripodi Luana , De Palma Antonella , Jones Rebecca , Ferrari Emanuele , Porretti Laura , Trombetta Elena , Merlo Giorgio R. , Mauri Pierluigi , Torrente Yvan 
Published: April 2022

AbstractDelayed wound healing and chronic skin lesions represent a major health problem. Over the past years, growth factors mediated by platelet-rich plasma (PRP) and cell-based therapies were developed as effective and affordable treatment able to improve wound healing capacity. We have advanced existing concepts to develop a highly efficient high-throughput protocol with proven application for the isolation of PRP and pro-angiogenic cells (AngioPRP). This protocol outlines the effectiveness of AngioPRP in promoting the critical healing process including wound closure, re-epithelialization, granulation tissue growth, and blood vessel regeneration. We coupled this effect with normalization of mechanical properties of rescued mouse wounds, which is sustained by a correct arrangement of elastin and collagen fibers. Proteomic analysis of treated wounds demonstrated a fingerprint of AngioPRP based on the up-regulation of detoxification pathway of glutathione metabolism, correlated to a decrease in inflammatory response. Overall, these results have enabled us to provide a framework for how AngioPRP supports wound healing, opening avenues for further clinical advances.
Die informierte Entscheidung als Ziel von evidenzbasierten Gesundheitsinformationen: Das Beispiel Krebsfrüherkennung
Authors: Schröer-Günther Milly , Koch Klaus 
Published: April 2022

ZusammenfassungUm Menschen eine informierte Entscheidung über die Teilnahme an Krebsfrüherkennungsuntersuchungen zu ermöglichen, müssen neben den Vorteilen auch Nachteile wie medizinische Risiken kommuniziert werden. Die in solchen Entscheidungshilfen enthaltenen Informationen sollten evidenzbasiert, neutral, ausgewogen und verständlich sowie in ihrem Umfang angemessen sein. Das Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG) wurde in den Jahren 2014 und 2015 vom Gemeinsamen Bundesausschuss (G-BA) beauftragt, Entscheidungshilfen in Form von Broschüren zur Teilnahme am Mammografie‑, Darmkrebs- und Zervixkarzinomscreening zu erstellen, die inzwischen im Einsatz sind.In diesem Beitrag wird die Entwicklung der Entscheidungshilfen beschrieben, wobei der Fokus auf deren Inhalten und den Ergebnissen der extern durchgeführten Nutzertestungen liegt. Letztere ergaben, dass 10–20 % der Testerinnen und Tester nach dem Lesen ihre Einstellung zur Teilnahme an der Früherkennungsuntersuchung innerhalb der 3 Kategorien „teilnahmebereit“, „unentschlossen“ und „nicht teilnahmebereit“ geändert haben. Das weist darauf hin, dass eine informierte Entscheidung durch die Materialien unterstützt wird. Die Nutzertestungen trugen dazu bei, die Entscheidungshilfen noch besser an die Informationsbedürfnisse der angesprochenen Gruppen anzupassen.
Composition, thickness, and homogeneity of the coating of core–shell nanoparticles—possibilities, limits, and challenges of X-ray photoelectron spectroscopy
Authors: Radnik Jörg , Knigge Xenia , Andresen Elina , Resch-Genger Ute , Cant David J. H. , Shard Alex G. , Clifford Charles A. 
Published: April 2022

AbstractCore–shell nanoparticles have attracted much attention in recent years due to their unique properties and their increasing importance in many technological and consumer products. However, the chemistry of nanoparticles is still rarely investigated in comparison to their size and morphology. In this review, the possibilities, limits, and challenges of X-ray photoelectron spectroscopy (XPS) for obtaining more insights into the composition, thickness, and homogeneity of nanoparticle coatings are discussed with four examples: CdSe/CdS quantum dots with a thick coating and a small core; NaYF4-based upconverting nanoparticles with a large Yb-doped core and a thin Er-doped coating; and two types of polymer nanoparticles with a poly(tetrafluoroethylene) core with either a poly(methyl methacrylate) or polystyrene coating. Different approaches for calculating the thickness of the coating are presented, like a simple numerical modelling or a more complex simulation of the photoelectron peaks. Additionally, modelling of the XPS background for the investigation of coating is discussed. Furthermore, the new possibilities to measure with varying excitation energies or with hard-energy X-ray sources (hard-energy X-ray photoelectron spectroscopy) are described. A discussion about the sources of uncertainty for the determination of the thickness of the coating completes this review.
Electrochemical sensors based on sewage sludge–derived biochar for the analysis of anthocyanins in berry fruits
Authors: Sfragano Patrick Severin , Laschi Serena , Renai Lapo , Fichera Michelangelo , Del Bubba Massimo , Palchetti Ilaria 
Published: April 2022

AbstractThe reutilization of waste and the reduction of the general environmental impact of every production are fundamental goals that must be achieved in the framework of a circular economy. Recycled carbon-rich materials may represent a promising alternative to other less-sustainable carbonaceous materials used in the production of electrochemical sensing platforms. Herein, we propose an innovative carbon paste electrode (CPE) composed of biochar derived from biological sludge obtained from municipal and industrial wastewater treatment plants. The physicochemical properties of the biochar after a chemical treatment with an acidic solution obtained from industrial by-products were investigated. The electrode surface characterization was carried out by analyzing common redox probes and multiple phenols bearing varying numbers of –OH and –OCH3 groups in their structure. Furthermore, the CPE was also tested on the evaluation of the phenolic fingerprints of Vaccinium myrtillus, Vaccinium uliginosum subsp. gaultherioides, and Fragaria × ananassa. Standard anthocyanin mixtures and extracts of the aforementioned fruits were analyzed to provide a phenolic characterization of real samples. The obtained results show that the sewage sludge–derived biochar can be a promising material for the development of electroanalytical sensors.
Graphical abstract
Occurrence and Temporal Variation of Technology-Critical Elements in North Sea Sediments—A Determination of Preliminary Reference Values
Authors: Klein Ole , Zimmermann Tristan , Ebeling Anna , Kruse Madita , Kirchgeorg Torben , Pröfrock Daniel 
Published: April 2022

AbstractAs interest in the investigation of possible sources and environmental sinks of technology-critical elements (TCEs) continues to grow, the demand for reliable background level information of these elements in environmental matrices increases. In this study, a time series of ten years of sediment samples from two different regions of the German North Sea were analyzed for their mass fractions of Ga, Ge, Nb, In, REEs, and Ta (grain size fraction < 20 µm). Possible regional differences were investigated in order to determine preliminary reference values for these regions. Throughout the investigated time period, only minor variations in the mass fractions were observed and both regions did not show significant differences. Calculated local enrichment factors ranging from 0.6 to 2.3 for all TCEs indicate no or little pollution in the investigated areas. Consequently, reference values were calculated using two different approaches (Median + 2 median absolute deviation (M2MAD) and Tukey inner fence (TIF)). Both approaches resulted in consistent threshold values for the respective regions ranging from 158 µg kg−1 for In to 114 mg kg−1 for Ce. As none of the threshold values exceed the observed natural variation of TCEs in marine and freshwater sediments, they may be considered baseline values of the German Bight for future studies.
Graphical Abstract
Iconic but Invasive: The Public Perception of the Chinese Windmill Palm (Trachycarpus fortunei) in Switzerland
Authors: Tonellotto Matteo , Fehr Vincent , Conedera Marco , Hunziker Marcel , Pezzatti Gianni Boris 
Published: April 2022

AbstractBiological invasions strongly increased during the last centuries and are challenging environmental managers worldwide. In this context, public acceptance of management measures is a key factor determining the long-term success of the control of invasive species. However, in the case of charismatic and iconic invasive species, the public has often been unwilling to accept strict management measures. Here, we studied the public perception of the Chinese windmill palm (Trachycarpus fortunei) in Switzerland, which is declared as invasive in southern Switzerland but also recognized as iconic. We conducted a nation-wide online survey in the multilingual and multicultural context of Switzerland, investigating the influence of social and cultural factors on the knowledge of, the attitude toward, and the willingness to control the invasive T. fortunei. Results confirm that the knowledge and perception of invasive plants have a strong social and cultural component and may vary greatly as a function of the cultural background, education level, age, and other social characteristics. Furthermore, information on the invasiveness of the focal species provided during the survey significantly affected informants’ perceptions, which are closely related to the acceptance of possible management and control measures. This allows us to highlight the importance of a holistic approach that includes targeted public information when dealing with biological invasions, especially in the case of charismatic and iconic species. Based on the obtained results, we suggest avenues for refining management and control strategies of T. fortunei in Switzerland, many of which generally applicable to other cases of invasive species.