bluuebunny/crossref_metadata_2025_split huggingface dataset:
Most Valuable Player based selective harmonic elimination in a cascaded H-bridge inverter for wide operating range
Authors: Sarwar Adil , Yadav Raj Kumar , Asim Mohammed , Saxena Dipti , Jain Chandra Prakash , Mewara Hari Shankar 
Published: July 2022

Abstract
Selective Harmonic Elimination PWM (SHEPWM) is a classical method of voltage control of the inverter while eliminating the undesirable lower order harmonics for low-frequency applications. Multivariable non-linear equations often result in SHE modulation scheme. In this work, a Most Valuable Player Algorithm (MVPA) has been applied to solve the non-linear SHE equations for the elimination of lower order harmonics in a cascaded H bridge multilevel inverter. The MVPA algorithm shows better convergence characteristics and wider modulation control compared to some popular meta-heuristic optimization methods. Optimized switching angles have been obtained for 5, 7 and 9 level inverters for different modulation index (MI) from 0.05 to 1. The Total Harmonic Distortion (THD) for the output voltage was found to be smoother compared to the powerful Differential Evolution (DE) algorithm for modulation index greater than 0.6. And for modulation index greater than 0.8, MVPA scores better than DE in terms of THD. Experimentally, the performance of MVPA has also been validated for 1-phase 5, 7 and 9 level cascaded H-bridge inverter and 5th, 5th and 7th, 5th, 7th, and 11th harmonic was eliminated respectively.
Purification and characterization of catechol oxidase from Posof Badele apple (Malus domestica L): in vitro and in silico studies
Authors: Çiğdem Ayhan , Güller Uğur 
Published: July 2022

Abstract
In the current study, polyphenol oxidase (PPO), responsible for enzymatic browning in fruits, was purified from Posof Badele apple (PB) (Malus domestica L.) in two steps as acetone precipitation and affinity chromatography. After purification, the purity of PBPPO was checked by using SDS-PAGE. It was figured out that PBPPO had maximum activity at pH 6.0 and 10 °C and it was stable at pH 5.5 and temperatures of 0–30 °C. Besides, it was determined that Al3+ and Cu2+ metal ions activated the enzyme and the PBPPO was strongly inhibited by ascorbic acid with a Ki constant of 1.67 ± 0.35 µM. Inhibitor-enzyme interactions were examined by molecular docking studies and it was revealed that ascorbic acid had the lowest docking score of −6.54 kcal/mol. We wanted to draw attention to the PB apple, which is red inside as well as outside and very rich in terms of nutrient content.
Caused motion events in Modern Uyghur: a typological perspective
Authors: Tusun Alimujiang , Hendriks Henriëtte 
Published: July 2022

Abstract
Talmy’s motion event typology (Talmy, Leonard. 2000. Towards a cognitive semantics: Conceptual structuring systems, vol. 2. Cambridge, MA: The MIT Press) has served as an influential framework for exploring event representation across languages. While confirming its basic premises, many studies argued that the typology cannot fully capture the vast intra- and inter-typological variations. Consequently, proposals have been made to expand the typology and/or reconceptualize it as a typology of constructional strategies for encoding events. This article furthers this line of inquiry by examining caused-motion expressions by adult speakers of an understudied Turkic language, Modern Uyghur. Systematic analyses of lexicalization patterns, that is, which components are typically selected for expression, how frequently they are selected, and how they are packaged in syntactic constructions, show that Uyghur is a prototypical verb-framed language. It differs most strikingly from English (considered satellite-framed) in terms of lexicalization patterns. Detailed comparisons with French and Turkish (putatively verb-framed) reveal intra-typological variations in that Uyghur speakers systematically used verb-framed constructions while French and Turkish speakers exhibit much flexibility and a general preference for satellite-framed constructions. Overall, our data lend support to Talmy’s typology conceived as a strategy-based typological framework.
Predictors of high dose of massed practice following stroke
Authors: Sabo Bishir , Abdullahi Auwal , Badaru Umaru Muhammad , Saeys Wim , Truijen Steven 
Published: July 2022

Abstract

Objective
The aim of this study is to determine the factors that affect patients’ ability to carry out high dose of massed practice.

Methods
Patients with stroke were included in the study if they had no severe impairment in motor and cognitive functions. Dose of massed practice, motor function, perceived amount and quality of use of the arm in the real world, wrist and elbow flexors spasticity, dominant hand stroke, presence of shoulder pain, and central post-stroke pain were assessed on the first day. Dose of massed practice was assessed again on the second day. The data were analyzed using descriptive statistics and linear multiple regression.

Results
Only motor function (β
= –0.310, r = 0.787, P < 0.001), perceived amount of use (β
= 0.300, r = 0.823; 95% CI = 0.34–107.224, P = 0.049), severity of shoulder pain (β
= –0.155, r = –0.472, P = 0.019), wrist flexors spasticity (β
= –0.154, r = –0.421, P = 0.002), age (β
= –0.129, r = –0.366, P = 0.018), dominant hand stroke (β
= –0.091, r = –0.075, P = 0.041), and sex (β
= –0.090, r = –0.161, P = 0.036) significantly influenced patients’ ability to carry out high dose of massed practice.

Conclusion
Many factors affect patients’ ability to carry out high dose of massed practice. Understanding these factors can help in designing appropriate rehabilitation.
Role of mixed surfactants system in preparation of silver nanoparticles
Authors: Mohamed Dalia E. , Mohamed Ammona S. , El-Dib Fawzia I. 
Published: July 2022

Abstract
Different morphologies of silver nanoparticles (AgNPs) are prepared by reducing silver nitrate with hydrazine hydrate in an aqueous solution in the presence of the anionic surfactant sodium 6,6′-((oxybis(ethane-2,1-diyl))bis(oxy))bis(3-dodecanoylbenzenesulfonate) (SOBS), the cationic surfactant cetyltrimethylammonium bromide (CTAB) and mixtures of these two surfactants as template. By mixing these cationic and anionic surfactants, different aggregates (template) were formed. The properties of the nanoproducts are studied by X-ray diffraction, transmission electron microscopy, energy dispersive X-ray analysis and Fourier transform infrared spectroscopy. The results show that the morphology of the nanosilver can be controlled by changing the ratio of cationic to anionic surfactant in the mixture, resulting in silver nanoparticles with high crystallinity and low aggregation.
Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases
Authors: Bergant Valter , Yamada Shintaro , Grass Vincent , Tsukamoto Yuta , Lavacca Teresa , Krey Karsten , Mühlhofer Maria‐Teresa , Wittmann Sabine , Ensser Armin , Herrmann Alexandra , vom Hemdt Anja , Tomita Yuriko , Matsuyama Shutoku , Hirokawa Takatsugu , Huang Yiqi , Piras Antonio , Jakwerth Constanze A , Oelsner Madlen , Thieme Susanne , Graf Alexander , Krebs Stefan , Blum Helmut , Kümmerer Beate M , Stukalov Alexey , Schmidt‐Weber Carsten B , Igarashi Manabu , Gramberg Thomas , Pichlmair Andreas , Kato Hiroki 
Published: July 2022

AbstractThe SARS‐CoV‐2 infection cycle is a multistage process that relies on functional interactions between the host and the pathogen. Here, we repurposed antiviral drugs against both viral and host enzymes to pharmaceutically block methylation of the viral RNA 2'‐O‐ribose cap needed for viral immune escape. We find that the host cap 2'‐O‐ribose methyltransferase MTr1 can compensate for loss of viral NSP16 methyltransferase in facilitating virus replication. Concomitant inhibition of MTr1 and NSP16 efficiently suppresses SARS‐CoV‐2 replication. Using in silico target‐based drug screening, we identify a bispecific MTr1/NSP16 inhibitor with anti‐SARS‐CoV‐2 activity in vitro and in vivo but with unfavorable side effects. We further show antiviral activity of inhibitors that target independent stages of the host SAM cycle providing the methyltransferase co‐substrate. In particular, the adenosylhomocysteinase (AHCY) inhibitor DZNep is antiviral in in vitro, in ex vivo, and in a mouse infection model and synergizes with existing COVID‐19 treatments. Moreover, DZNep exhibits a strong immunomodulatory effect curbing infection‐induced hyperinflammation and reduces lung fibrosis markers ex vivo. Thus, multispecific and metabolic MTase inhibitors constitute yet unexplored treatment options against COVID‐19.
Vitamin D receptor enhances NLRC4 inflammasome activation by promoting NAIPs–NLRC4 association
Authors: Chen Xin , Zhang Zaikui , Sun Naishuang , Li Jinzhou , Ma Zemeng , Rao Zebing , Sun Xiaomeng , Zeng Qiang , Wu Yuxuan , Li Jiahuang , Zhang Jing , Chen Yunzi 
Published: July 2022

AbstractInflammasomes are cytosolic multiprotein complexes that initiate host defense against bacterial pathogens. The nucleotide‐binding oligomerization domain (NOD)‐like receptor (NLR) family caspase‐associated recruitment domain‐containing protein 4 (NLRC4) inflammasomes plays a critical role in the inflammatory response against intracellular bacterial infection. The NLR family apoptosis inhibitory proteins (NAIPs) detect Flagellin or type III secretion system (T3SS) microbial components to activate NLRC4 inflammasome. However, the underlying mechanism of NLRC4 inflammasome activation is not completely understood. Here, we show that the vitamin D receptor (VDR) is an essential immunological regulator of the NLRC4 inflammasome. Conditional VDR knockout mice (VDRflox/flox lyz2‐Cre) exhibited impaired clearance of pathogens after acute Salmonella Typhimurium infection leading to poor survival. In macrophages, VDR deficiency reduced caspase‐1 activation and IL‐1β secretion upon S. Typhimurium infection. For NAIPs act as upstream sensors for NLRC4 inflammasome assembly, the further study demonstrated that VDR promoted the NAIP–NLRC4 association and triggered NAIP–NLRC4 inflammasome activation, not NLRP3 activation. Moreover, Lys123 residue of VDR is identified as the critical amino acid for VDR‐NLRC4 interaction, and the mutant VDR (K123A) effectively attenuates the NLRC4 inflammasome activation. Together, our findings suggest that VDR is a critical regulator of NAIPs–NLRC4 inflammasome activation, mediating innate immunity against bacterial infection.
Criteria for the establishment of a new behavioural addiction •
Authors: Gullo Matthew J. , Wood Andrew P. , Saunders John B. 
Published: July 2022

Abstract
When does repeated behaviour constitute behavioural addiction? There has been considerable debate about non-substance-related addictions and how to determine when impaired control over a behaviour is addiction. There are public health benefits to identifying new behavioural addictions if intervention can improve outcomes. However, criteria for establishing new behavioural addictions must guard against diagnostic inflation and the pathologizing of normal problems of living. Criteria should include clinical relevance (Criterion 1), alignment with addiction phenomenology (Criterion 2) and theory (Criterion 3), and taxonomic plausibility (Criterion 4). Against such criteria, evidence does not yet support classification of pornography-use and buying-shopping disorders as addictions.
Mental and sexual health perspectives of the International Classification of Diseases (ICD-11) Compulsive Sexual Behavior Disorder •
Authors: Lew-Starowicz Michal , Coleman Eli 
Published: July 2022

Abstract
After introduction of compulsive sexual behavior disorder (CSBD) in the ICD-11, many questions regarding etiology, classification and diagnostic criteria remain unanswered, providing rationale for further research. In this commentary, we critically review the ongoing discussion reflected in some relevant articles, and try to point out the risks of oversimplification of the broad clinical phenomenon, as well as attract attention to the neglected aspects, such as psychosexual development, intimacy disorder and the role of sexological expertise in the assessment and treatment of individuals presenting with out-of-control sexual behaviors. We also advocate for multimodal, transtheoretical approach and suggest that CSBD may be reconsidered as a condition related to sexual health.
The social representation of the woman about the cancer: implications for the nursing care
Authors: De Lima Roberta 
Published: July 2022

The object of this research is the social representation of the cancer in the women with the breast cancer diagnosis and its implications in the nursing care. The theoretical reference is the social representation, according to Serge Moscovici. The objectives were characterize the social representation of the women about the cancer; analyze the implications of these representations in the care of their body and in their personal and social life and discuss the implications of these representations in the participation of the woman in her treatment and in the nursing care.The subjects were sixteen women that had the breast cancer diagnosis, matriculated in a public hospital . We utilized as collection data techniques the semi structured interview, the free association of ideas and the free observation. The data were organized in three categories: 1)the disease: the cancer and its metaphors; 2)the body and its psychosocial marks; 3) the care and its slopes. The results evidenced that the social representation of the cancer is still the one of an incurable disease, the one that affects the psychological scope, familiar and social of the woman. We concluded that the expressive slope of the care, evidenced in the relation established between the nurse and the client, is a useful way for the promotion of the well-being to the woman that, before needing of atechnical/technological arsenal needed to his treatment and cure, needs of an space that permits flowall the subjective load that mark the process of making sick, making possible more individualized care and the attention to the needs of psychosocial seal.
The Professional Master in Nursing at the Fluminense Federal University Nursing School will begin in 2004
Authors: Cruz Isabel Cristina Fonseca da 
Published: July 2022

The role of nurse with Master Degree represents an challenge career opportunity for professional nurses. Currently, there are only 2 Professional Master in Nursing in Brazil, one is at São Paulo Federal University (SP) and the other, recently approved by CAPES, is at Fluminense Federal University (RJ). At the Fluminense Federal University, the Professional Master in Nursing Program was designed for experienced nurses who is seeking preparation for advanced practice as a clinical specialist, educator, researcher, or administrator. It includes course work and clinical experience in advanced health assessment, physiology, pathophysiology and pharmacology, as well as research, nursing theories, health promotion and disease prevention, healthcare policy, health and culture, diagnostic reasoning, and clinical decision making. In addition to course work, nurses are required to publish an original article and to produce a dissertation. The Professional Master in Nursing encompass a 2 year program of study with specialized clinical experiences. Upon graduation, the nurse will have a base of knowledge in a specific area of nursing care; and can participate knowledgeably in research activity and application. Advanced clinical education and experience based on scientifc evidences have been identified as requirements for practice as a nurse with Professional Master Degree. The nursing practice has recently expanded as a result of changes occurring in health care settings, including increased acuity of hospitalized patients, demands of management hability to reduce length of stay and to coordinate patient/family care. The scope of practice for nurses with a Professional Master Degree is broad-based and involves, mainly, providing advanced nursing care to patients and their families according to the practice setting and patient population. For example, it may comprehend also therapeutic procedure work, aspects of case management, discharge planning, monitoring quality standards, clinical research, undergraduate preceptorship, and inservice education of nursing staff for the instituition. The Professional Master in Nursing at the Fluminense Federal University will offer a unique advanced practice opportunity for nurses to develop their nursing careers and for healthcare institutions and nursing faculties to improve the quality of their services.The Professional Master in Nursing at the Fluminense Federal University will be offered in March 2004. Do not miss the deadlines!
Thirteen national brazilian nursing research congress (SENPE) june 2005, São Luiz, Maranhão
Authors: Cruz Isabel Cristina Fonseca da 
Published: July 2022

Make plans now to attend the Thirteen National Brazilian Nursing Research Congress in June 14-17th, 2005. This meeting will be held in São Luis, Maranhão, Brazil.The objectives are: promote the exchange of research and clinical scholarship in an national/international forum; advance the science of nursing by disseminating research findings that influence practice, education, administration and health care policy; and explore opportunities for national/international collaboration in nursing research, practice, education, administration and health care policy.HOTEL AND TRAVEL Learn more about the ammenities and setting of São Luis, Maranhão, Brazil, athttp://www.cidadeshistoricas.art.br/saoluis/ or http://www.wojner.de/slz/ (in English).Informations at : http://www.visaoperfileventos.com.br/eventos.htm aben@abennacional.org.br or http://www.abennacional.org.br/
Estresse e comportamento alimentar durante a graduação de enfermagem: estudo transversal
Authors: Costa Jéssika Wanessa Soares , Silva Kézia Katiane Medeiros da , Bezerra Clarissa Maria Bandeira , Silva Danila Maria da , De Martino Milva Maria Figueiredo 
Published: July 2022

Objetivo: Analisar os níveis de estresse e sua associação com o comportamento alimentar dos discentes da graduação em Enfermagem de uma universidade pública. Método: estudo transversal, observacional, com abordagem quantitativa. O estudo será desenvolvido no Departamento de Enfermagem da Universidade Federal do Rio Grande do Norte. Será aplicada uma ficha de identificação para o reconhecimento sociodemográficos, juntamente com: a escala para Avaliação de Estresse em Estudantes de Enfermagem e o Questionário Holandês do Comportamento Alimentar. Resultados esperados: identificar a associação entre o estresse e o comportamento alimentar entre os discentes da graduação em Enfermagem. O estudo será significativo para a formação de novos profissionais, mediante análise das condições alimentares e a influencia do estresse na formação profissional, corroborando para elaboração futura de estratégias para minimizar os efeitos do estresse, e consequentemente, das disfunções na alimentação dos estudantes.
Avaliação do gerenciamento de resíduos de serviços de saúde em hospital universitário
Authors: Galiaço-Souza Alzira Caroline , Lima Marcia Valéria Rosa , Cozendey-Silva Eliana Napoleão 
Published: July 2022

Objetivo: Avaliar as etapas de manejo dos Resíduos de Serviços de Saúde (RSS) do Grupo D em um hospital universitário. Método: Pesquisa de campo, do tipo exploratória e descritiva, de abordagem quanti-qualitativa. Utiliza instrumento validado, o Health-Care Waste Management – Rapid Assessment Tool Versão Brasileira (HCWM-RAT Versão Brasileira), para coleta de dados em campo. A preparação dos dados, procedimentos estatísticos e analíticos serão viabilizados por meio do software IBM SPSS©. Resultados esperados: Contribuir para a implementação e acompanhamento das práticas preconizadas pela Agência Nacional de Vigilância Sanitária e a Política Nacional de Resíduos Sólidos; a ampliação da compreensão do sistema de gestão de RSS; a redução de custos do gerenciamento de resíduos; e, o reforço do uso da evidência científica em gestão ambiental no setor saúde, uma vez que ela informa e subsidia a tomada de decisão gerencial e política.
MODIFIED MULTI-LEVEL STEGANOGRAPHY TO ENHANCE DATA SECURITY
Authors: Elshare Shadi , EL Emam Nameer N 
Published: July 2022

Data-hiding using steganography algorithm becomes an important technique to prevent unauthorized users to have access to a secret data. In this paper, steganography algorithm has been constructed to hide a secret data in a gray and a color images, this algorithm is named deep hiding/extraction algorithm (DHEA) to modify multi-level steganography (MLS). The suggested hiding algorithm is based on modified least significant bit (MDLSB) to scatter data in a cover-image and it utilizes a number of levels; where each level perform hiding data on a gray image except the last level that applies a color image to keep secret data. Furthermore, proper randomization approach with two layers is implemented; the first layer uses random pixels selection for hiding a secret data at each level, while the second layer implements at the last level to move randomly from segment to the others. In addition, the proposed hiding algorithm implements an effective lossless image compression using DEFLATE algorithm to make it possible to hide data into a next level. Dynamic encryption algorithm based on Advanced Encryption Standard (AES) is applied at each level by changing cipher keys (Ck) from level to the next, this approach has been applied to increase the security and working against attackers. Soft computing using a meta-heuristic approach based on artificial bee colony (ABC) algorithm has been introduced to achieve smoothing on pixels of stego-image, this approach is effective to reduce the noise caused by a hidden large amount of data and to increase a stego-image quality on the last level. The experimental result demonstrates the effectiveness of the proposed algorithm with bee colony DHA-ABC to show high-performing to hide a large amount of data up to four bits per pixel (bpp) with high security in terms of hard extraction of a secret message and noise reduction of the stego-image. Moreover, using deep hiding with unlimited levels is promising to confuse attackers and to compress a deep sequence of images into one image.