bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’agriculture et la pêche au centre du débat franco-espagnol, 1976-1986
Authors: García Sergio Molina 
Published: June 2022

Résumé :
Le processus de négociation de l’Espagne pour son intégration
dans les Communautés économiques européennes était très complexe. L’un
des problèmes qui conditionnaient le plus l’adhésion était celui de
l’agriculture et de la pêche, qui se posait avec la France en raison
d’une éventuelle concurrence pour les produits méditerranéens et d’un
conflit d’intérêts dans le golfe de Gascogne. L’objectif principal de
cet article est de souligner l’importance des débats franco-espagnols
sur l’agriculture dans le processus d’intégration espagnole dans la
CEE.
Du Black Power au mouvement Black Lives Matter
Authors: Bertail Thomas 
Published: June 2022

Résumé :
À partir de la seconde moitié des années 1960, l’expression Black Power prend la forme
d’un slogan largement diffusé et repris au point de devenir le symbole
de cette période qui voit naître de nouvelles organisations radicales
et révolutionnaires africaines-américaines telles que le Black Panther Party (BPP).
Cet article interroge la nécessité, pour des organisations telles que
le BPP, de provoquer une rupture avec les traditions iconographiques
par l’adoption d’un langage visuel faisant usage de codes de
reconnaissance internes afin de revendiquer une expérience et une
identité collectives pour en faire un vecteur de visibilité et de
lutte contre la naturalisation des stéréotypes. Il s’agira ainsi
d’analyser l’influence de la période du Black Power et de sa dimension esthétique à
l’aune du mouvement Black
Lives Matter.
Covid-19 and Mucormycosis Superinfection
Authors: Garg Shubham , Masheshwari Dilip , Bhushan Bharat , Sardana Vijay , Jain Raj Kumar 
Published: June 2022

Background:
Mucormycosis (MCR) has been increasingly described in patients with coronavirus disease 2019 (COVID-19), but the epidemiological factors, neurological presentation, and outcome of such patients are not well described.

Aims:
To study the patient demographics, presenting symptoms and signs, the role of co-morbidities, medications used to treat COVID-19, and the outcomes of management and to study the spectrum of neuraxis involvement and its outcome.

Methods:
It was a prospective, observational, cross-sectional hospital-based single center cohort study. Confirmed MCR cases with and without COVID-19 were collected. The study was carried out over a period of 3 months from May to July 2021, followed by 3-month follow-up. Information on epidemiological factors, neurological findings, treatment (including medical and surgical treatment), and outcome was recorded.

Results:
A total of 141 patients were diagnosed with MCR, out of which 98 were COVID-associated MCR (CAM). The CAM incidence was 0.39% among COVID-19-positive patients. The MCR case fatality rate at 90 days was 43.9% but was higher for CAM than for non-CAM patients. Older ages (>50 years), diabetes mellitus, multiple risk factors, diabetic ketoacidosis on admission, brain involvement, and history of COVID-19 pneumonitis were associated with a higher risk for death.

Conclusions:
Possibly because of improper usage of corticosteroids, zinc, oxygen, and tocilizumab, there was sudden surge of cases of MCR in the COVID-19 pandemic. Therefore, treating physicians should use the COVID-19 pneumonia regimen judiciously. Neurological involvement itself is a poor prognostic sign, but combined surgical and medical management exhibited better outcome.
Neuropathy in Parkinson's Disease
Authors: Soumiya Ravi , Paul Birinder S. , Aggarwal Riya , Paul Gunchan 
Published: June 2022

Methods:
This was a hospital based observational cross-sectional study of PD patients attending the Neurology OPD of a tertiary care hospital. The prevalence and type of neuropathy was determined using the validated MNSI scale. The nutritional status was assessed using MNA score and PDQ-39 was used for assessing quality of life. Patients with and without neuropathy were compared to ascertain risk factors for neuropathy.

Results:
Twenty-four out of 93 PD patients (26%) had neuropathy and 12 (50%) out of them had painful neuropathy. Older patents and those who had longer duration of disease had higher prevalence of neuropathy. In addition there was significant correlation with malnutrition and neuropathy. 79% of patients with neuropathy had abnormal nutritional status. On comparison of patients with painful neuropathy as compared to those without pain, Vitamin B 12 levels were found to be low only in the former group.

Conclusions:
Our study shows that there is significant prevalence of neuropathy in PD patents that affects the quality of life of PD patients. Neuropathy in PD is disease dependent and is precipitated by malnutrition. Hence, neuropathy must be timely diagnosed and effective nutritional management may help to improve the patient's quality of life.
The optimal concentration of intralesional triamcinolone acetonide for patchy alopecia areata
Authors: Su Hsuan-An , Chen Yu-Tsung , Chen Yu-Chia 
Published: June 2022

Background:
Intralesional steroid treatment for alopecia areata (AA) has been developed for decades, yet the optimal concentration of triamcinolone acetonide (TrA) is not well-established.

Objectives:
This review aims to determine the optimal concentration of intralesional TrA in treating patchy AA.

Methods:
We conducted a systematic review and meta-analysis, and searched the Cochrane Library, Embase, and PubMed databases on July 4, 2021, to identify randomized or nonrandomized comparative studies reporting the response rates and/or adverse events among AA patients treated with various concentrations of TrA. The meta-analysis of proportions and odds ratios was analyzed using random-effects modeling.

Results:
Nineteen studies and a total of 783 participants were included. The estimated response rate of 5 mg/dl (74.82%, 95% confidence interval [CI] 64.99%–83.50%) was shown to be more efficacious than 2.5/3.33 mg/dl (38.64%, 95% CI 16.98%–62.99%) but similar to 10 mg/dl (71.06%, 95% CI 59.72%–81.20%), while pooled estimate of odds ratios revealed higher efficacy with 10 mg/dl than 5 mg/dl (odds ratio = 1.64, 95% CI 1.05–2.58, P = 0.031). The rates of skin atrophy were 18.05% (95% CI, 10.32%–27.38%), 11.49% (95% CI, 2.86%–24.84%), and 3.85% (95% CI, 1.27%–14.01%) in groups 10, 5, and 2.5/3.33 mg/dl, respectively. Higher concentration is associated with more skin atrophy in a dose-dependent fashion (P = 0.012). Heterogeneity among studies in the meta-analyses was high.

Conclusion:
The optimal intralesional concentration of TrA for patchy AA is probably 10 mg/dl with acceptable adverse events.
Extramammary Paget's disease
Authors: Yen Chia-Hsien , Lee Chih-Hung , Ho Ji-Chen 
Published: June 2022

Background:
Extramammary Paget's disease (EMPD) is a rare malignancy occurring on apocrine sweat gland-bearing skin with occasional association with internal cancers. Its epidemiological characteristics are different between populations in Asian and Western countries.

Objectives:
The aim of this study was to report the clinical experience of EMPD in a single medical center in Taiwan, compare our results with previous literature, and provide strategies for diagnostic workup.

Methods:
Medical records and biopsies of 34 Taiwanese patients with EMPD, treated in a single medical center in Kaohsiung, Taiwan, from January 2000 to December 2019, were reviewed. The clinicopathological features, biological behavior, management, and follow-up courses of these patients were analyzed.

Results:
We found a male predominance in our 34 patients with EMPD, and most patients were diagnosed in their 70s. Only four patients (11.8%) had an associated malignancy while the rest had a primary cutaneous lesion. Most patients (22, 64.7%) underwent wide excision (22, 64.7%), with the rest adopting other various therapeutic modalities. The 5-year overall survival rate was 76.5%, and the statistically significant prognostic factors for survival were lymph node involvement (P < 0.001) and dermal invasion (P = 0.022).

Conclusion:
In summary, this single-center study described the clinical and histopathologic features of patients with EMPD in Taiwan with a review of literature. We also proposed a complete systemic workup when the diagnosis was made and an extended follow-up period as long as 5 years after the initial treatment.
Serum and sebum pharmacokinetics evaluation of a novel formulation of itraconazole in healthy volunteers
Authors: Mahajan Harshal , Jain Gaurav K. , Dhoot Dhiraj , Deshmukh Gaurav A. , Barkate Hanmant V. 
Published: June 2022

Background and Objective:
Super bioavailable itraconazole is a newer formulation of itraconazole, which overcomes challenges encountered with the use of conventional itraconazole like interpatient variability, limited absorption, reduction in its absorption with co-administered gastric acid lowering agents, etc. The present study was done to evaluate the plasma pharmacokinetics, sebum concentrations of super bioavailable itraconazole in comparison with conventional itraconazole.

Materials and Methods:
Twelve healthy Asian Indian male healthy volunteers were enrolled in single-center, open-labeled, two treatments, multi-dose, parallel pharmacokinetic study. Test drug (T), i.e. super bioavailable itraconazole 50 mg, was given to six volunteers twice daily after meals for 7 continuous days. Reference drug (R), i.e. conventional itraconazole 100 mg, was given in similar way to the remaining six volunteers. Concentration of the itraconazole in plasma in both the groups was quantified by using high performance liquid chromatography. Concentration of the itraconazole in sebum was measured by paper absorption method.

Results:
The plasma concentration of itraconazole in both the groups was comparable at all-time points. The maximum concentration (Cmax) and area under curve in test group was higher as compared to reference group. The relative bioavailability of test drug was 107% as compared to the reference drug. The intersubject variability was less in test group (8.37%) as compared to reference drug (19.82%). At day 7, the mean sebum concentration of itraconazole in test drug group was 11.6% higher as compared to reference drug (P = 0.01).

Conclusion:
It is apparent from the study outcomes that super bioavailable itraconazole (50 mg) is bioequivalent to the conventional itraconazole (100 mg) along with less intersubject variability, and most importantly higher sebum concentration as compared to conventional itraconazole.
Decrease in estimated glomerular filtration rates in non-small cell lung cancer patients treated with crizotinib
Authors: Iriagac Yakup , Cavdar Eyyup , Karaboyun Kubilay , Tacar Seher Yildiz , Akkoc Mustafayev Fatma Nihan , Celik Emir , Avci Okan , Okutur Sadi Kerem , Koral Lokman , Demirci Nebi Serkan , Ozgun Alpaslan , Seber Erdogan Selcuk 
Published: June 2022

ABSTRACT

Introduction:
Crizotinib is a tyrosine kinase inhibitor used in patients with non-small cell lung cancer, and there are uncertainties about its effect on kidney function. In this study, it was aimed to document the possible adverse effect of the drug on kidney functions.

Materials and Methods:
The estimated glomerular filtration rates (eGFRs) of the patients were calculated by creatinine-based Chronic Kidney Disease Epidemiology Collaboration and compared by months using the paired samples t-test. Kaplan–Meier survival method was used for progression-free survival and overall survival (OS) analysis.

Results:
Twenty-six patients who received crizotinib were included in the study, and the median progression-free survival time with crizotinib was 14.2 months and the median OS time was 27.4 months. There was a significant reduction of eGFR after the 1st month of crizotinib treatment when compared to the rate before treatment initiation (P < 0.001). The eGFR values at the end of the 1st month and the 2nd month of treatment and the 2nd and 3rd months of treatment were statistically similar (P = 0.086, P = 0.663; respectively). This decrease in eGFR values was reversible, and there was no difference detected between pretreatment and posttreatment discontinuation (P = 0.100).

Conclusion:
A reversible decrease in renal functions was detected in patients using crizotinib. When the literature data are examined, it is thought that the reason for this decrease may be related to the increase in renal inflammation or a pseudo decrease due to the decrease in creatinine excretion. When evaluating renal functions in these patients, using noncreatine-based (iothalamate, etc.) calculations can give more accurate results.
Families of singular Kähler–Einstein metrics
Authors: Di Nezza Eleonora , Guedj Vincent , Guenancia Henri 
Published: June 2022

Refining Yau’s and Kołodziej’s techniques, we establish very precise uniform a priori estimates for degenerate complex Monge–Ampère equations on compact Kähler manifolds, that allow us to control the blow up of the solutions as the cohomology class and the complex structure both vary.
We apply these estimates to the study of various families of possibly singular Kähler varieties endowed with twisted Kähler–Einstein metrics, by analyzing the behavior of canonical densities, establishing uniform integrability properties, and developing the first steps of a pluripotential theory in families. This provides interesting information on the moduli space of stable varieties, extending works by Berman–Guenancia and Song, as well as on the behavior of singular Ricci-flat metrics on (log) Calabi–Yau varieties, generalizing works by Rong–Ruan–Zhang, Gross–Tosatti–Zhang, Collins–Tosatti and Tosatti–Weinkove–Yang.
Comparing Online and Physical Social Entrepreneurship Training: Lessons Learned moving Online
Authors: Phillips Robert 
Published: June 2022

With soft skills such as networking, groupwork and team building being key aspects of entrepreneurship education, the Covid-19 pandemic arguably has had a larger impact than on many other subject areas by the need to switch online. Having run a four day, fully immersive Enterprise School for social enterprise off campus for many years, the Covid-19 pandemic saw a need to move online with a danger of these key aspects being lost. By using the more familiar local area, spreading out the time between sessions and increasing the interactions with guest mentors we were able to mitigate for some of these issues. We discuss the advantages and disadvantages of moving online with qualitative feedback from students and staff including some unexpected benefits such as improved accessibility for some students.
Modifications and Accommodations for Higher Education Students with Special Educational Needs
Authors: Sokolová Lenka , Lemešová Miroslava , Groma Marian 
Published: June 2022

Students with learning disabilities and attention disorders in higher education are often described as individuals with invisible disorders. This perception may lead to misinterpreting and stereotyping of their educational needs and also to ineffective accommodations. This study aims to review recent research on accommodations and modifications for individuals with learning disabilities and attention disorders in higher education. The authors identified ten studies published between 2017 and 2021 focused on accommodations for higher education students with learning disabilities (especially dyslexia) and attention disorders (ADHD). The recent research results show that learning difficulties are often manifested during traditional teaching and evaluation. Innovative student-centred approaches might be beneficial not only for students with special educational needs. To be effective the accommodations should be designed concerning personal and environmental factors.
Harnessing the potential of online learning in Italian Universities: form blended classes to MOOCs
Authors: Chavarria Arnau Alexandra , Dal Bon Cecilia 
Published: June 2022

In this paper some integrated teaching experiences conducted at the University of Padua and particularly one of the courses in the Archaeology area are presented here, in order to show numerous benefits that this kind of learning method can offer: flexibility, time and cost efficiency, more convenience for working students or those with other commitments, the ability to review content several times, greater accessibility for students with disabilities, and specially high degree of student engagement and interactivity . The characteristics of some teaching materials created or used exclusively online, for open and free teaching are described, including the impact they might have on lifelong learning, in the dissemination of our subject, and in the promotion of the territory at an international level.
Pedagogy and new humanism at the time of Covid
Authors: Tataranni Anna 
Published: June 2022

Schools, society as a whole, have been deeply affected by the emergence of Covid19. The shift to distance teaching and learning has exacerbated many pre- existing vulnerabilities and inequalities in education systems. This paper argues for the urgency for school systems to accept new challenges in training, organizing inclusive environments towards the promotion of collective social and critical capacities, in synergy with the digital within a school that broadens its horizons, its classrooms, capable of bringing in human riches, assuming the richness of the student as a unique and unrepeatable subject who develops thanks to the relationship with the other, capable of transformative resilience, which looks at the human becoming by virtue of the encounters of places, including virtual ones, that are experienced in the course of life. A school pervaded by a new humanism, the only true wealth.
"Interfaith dialogue in limbo: How can tradition work against religious purposes?"
Authors:   Ovidius University of Constanta, Department of Theology, Constanta, Romania, Ciocan Tudor-Cosmin 
Published: June 2022

When we talk about dialogue, we always start looking for ways to best present the content of our speech. Approaching another through dialogue does not seem to care too much about the will or desire to accept the otherness for dialogue even if this is the basis of the binary formula of dialogue. Yet, in the case of religious dialogue, things are not at all so clear or proactive; instead, this (accepting otherness) is usually the central issue of interreligious dialogue. However, when we finally manage to bring together two or more religious representatives for dialogue, the most intriguing aspect of the dialogue is less emphasized on the content and issues to be brought to the attention of the participants and more on the issue of accepting, tolerating all others’ traditions through this dialogue. Nervousness, anxiety, discomfort, and squirming are the habitual and, even more shocking, "expected" features in interfaith dialogue. Well, if this is the main problem in interfaith - being able to bring acceptance in this "toxic" environment - then this would be a step forward. But probably all these are since, at present, the construction of interreligious dialogue is still in progress, about to be polished and become a formal custom, an emerging tradition of the current era. However, is the content that all participants in the interfaith dialogue bring, our particular traditions, to blame for this challenge? Can they help us build the bridge or, on the contrary, put interfaith in a limbo state, waiting for a redeemer? To pinpoint the direction in which interreligious dialogue is heading, we must better evaluate and understand a "tradition", what it is, how it works, and why it is developed and preserved. What is the significance of a tradition for people in general and a religious group in particular? How deeply rooted is it in human thinking and how valuable to fight for it? And then, can we consider changing, altering, or even removing a whole tradition from our perspective? If so, [regardless of the response] what is then the impact of [any] tradition on us and our reactions to the current issues, therefore to human endeavor? This article illustrates the role that tradition plays in peoples' views of the world and how tradition influences their behavior and attitudes toward certain practices and against a current acquisition of interreligious relationships, namely interreligious dialogue.
Australian wildfire smoke in the stratosphere: the decay phase in 2020/2021 and impact on ozone depletion
Authors: Ohneiser Kevin , Ansmann Albert , Kaifler Bernd , Chudnovsky Alexandra , Barja Boris , Knopf Daniel A. , Kaifler Natalie , Baars Holger , Seifert Patric , Villanueva Diego , Jimenez Cristofer , Radenz Martin , Engelmann Ronny , Veselovskii Igor , Zamorano Félix 
Published: June 2022

Abstract. Record-breaking wildfires raged in southeastern Australia in late December 2019 and early January 2020. Rather strong pyrocumulonimbus (pyroCb) convection developed over the fire areas and lofted enormous amounts of biomass burning smoke into the tropopause region and caused the strongest wildfire-related stratospheric aerosol perturbation ever observed around the globe. We discuss the geometrical, optical, and microphysical properties of the stratospheric smoke layers and the decay of this major stratospheric perturbation. A multiwavelength polarization Raman lidar at Punta Arenas (53.2∘ S, 70.9∘ W), southern Chile, and an elastic backscatter Raman lidar at Río Grande (53.8∘ S, 67.7∘ W) in southern Argentina, were operated to monitor the major record-breaking event until the end of 2021. These lidar measurements can be regarded as representative for mid to high latitudes in the Southern Hemisphere. A unique dynamical feature, an anticyclonic, smoke-filled vortex with 1000 km horizontal width and 5 km vertical extent, which ascended by about 500 m d−1, was observed over the full last week of January 2020. The key results of the long-term study are as follows. The smoke layers extended, on average, from 9 to 24 km in height. The smoke partly ascended to more than 30 km height as a result of self-lofting processes. Clear signs of a smoke impact on the record-breaking ozone hole over Antarctica in September–November 2020 were found. A slow decay of the stratospheric perturbation detected by means of the 532 nm aerosol optical thickness (AOT) yielded an e-folding decay time of 19–20 months. The maximum smoke AOT was around 1.0 over Punta Arenas in January 2020 and thus 2 to 3 orders of magnitude above the stratospheric aerosol background of 0.005. After 2 months with strongly varying smoke conditions, the 532 nm AOT decreased to 0.03-0.06 from March–December 2020 and to 0.015–0.03 throughout 2021. The particle extinction coefficients at 532 nm were in the range of 10–75 Mm−1 in January 2020 and, later on, mostly between 1 and 5 Mm−1. Combined lidar–photometer retrievals revealed typical smoke extinction-to-backscatter ratios of 69 ± 19 sr (at 355 nm), 91 ± 17 sr (at 532 nm), and 120 ± 22 sr (at 1064 nm). An ozone reduction of 20 %–25 % in the 15–22 km height range was observed over Antarctica and New Zealand ozonesonde stations in the smoke-polluted air, with particle surface area concentrations of 1–5 µm2 cm−3.