bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inside the hologram: reconstructing the bulk observer’s experience
Authors: Jafferis Daniel Louis , Lamprou Lampros 
Published: March 2022

Abstract
We develop a holographic framework for describing the experience of bulk observers in AdS/CFT, that allows us to compute the proper time and energy distribution measured along any bulk worldline. Our method is formulated directly in the CFT language and is universal: it does not require knowledge of the bulk geometry as an input. When used to propagate operators along the worldline of an observer falling into an eternal black hole, our proposal resolves a conceptual puzzle raised by Marolf and Wall. Notably, the prescription does not rely on an external dynamical Hamiltonian or the AdS boundary conditions and is, therefore, outlining a general framework for the emergence of time.
Large logarithms from quantum gravitational corrections to a massless, minimally coupled scalar on de Sitter
Authors: Glavan D. , Miao S. P. , Prokopec T. , Woodard R. P. 
Published: March 2022

AbstractWe consider single graviton loop corrections to the effective field equation of a massless, minimally coupled scalar on de Sitter background in the simplest gauge. We find a large temporal logarithm in the approach to freeze-in at late times, but no correction to the feeze-in amplitude. We also find a large spatial logarithm (at large distances) in the scalar potential generated by a point source, which can be explained using the renormalization group with one of the higher derivative counterterms regarded as a curvature-dependent field strength renormalization. We discuss how these results set the stage for a project to purge gauge dependence by including quantum gravitational corrections to the source which disturbs the effective field and to the observer who measures it.
The influence of weight-bearing status on post-operative mobility and outcomes in geriatric hip fracture
Authors: Tarrant Seth Michael , Attia John , Balogh Zsolt Janos 
Published: March 2022

Abstract
Purpose
We hypothesized that unrestricted or full weight-bearing (FWB) in hip fracture would increase the opportunity to mobilize on post-operative day 1 (POD1mob) and be associated with better outcomes compared with restricted weight-bearing (RWB).

Methods
Over 4 years, 1514 geriatric hip fracture patients aged 65 and above were prospectively recruited. Outcomes were compared between FWB and RWB patients. The primary outcome was 30-day mortality. Secondary outcomes were immobility-related adverse events, length of stay (LOS), and reoperation for failure. Causal effect modelling and multivariate regression with mediation analyses were performed to examine the relation between weight-bearing status (WBS), POD1mob, and known mortality predictors.

Results
FWB was allowed in 1421 (96%) of 1479 surgically treated patients and RWB enforced in 58 (4%) patients. Mortality within 30 days occurred in 141 (9.9%) of FWB and 3 (5.2%) of RWB patients. In adjusted analysis, RWB did not influence 30-day mortality (OR 0.42, 95% CI 0.15–01.13, p = 0.293), with the WBS accounting for 91% of the total effect on mortality and 9% contributed from how WBS influenced the POD1mob. RWB was significantly related to increased DVT (OR 7.81, 95% CI: 1.81–33.71 p = 0.002) but no other secondary outcomes. Patients that did not have the opportunity to mobilize had increased 30-day mortality (OR 2.31, 95% CI 1.53–3.48 p < 0.001).

Conclusion
Restricted weight-bearing was not associated with increased 30-day mortality. Only a small proportion of this effect was mediated by POD1mob. Whilst post-surgical WBS may be difficult to influence for cultural reasons, POD1mob is an easily modifiable target that is likely to have a greater effect on 30-day mortality.

Level of evidence
Level III, observational study.
Re-rupture rate and the post-surgical meniscal injury after anterior cruciate ligament reconstruction with the Press-Fit-Hybrid®-technique in comparison to the interference screw technique: a retrospective analysis of 200 patients with at least 3 years follow-up
Authors: Volz Richard , Borchert Gudrun H. 
Published: March 2022

Abstract
Background
There is currently no consensus regarding the preferred surgical procedure for the reconstruction of anterior cruciate ligament (ACL). The interference screw technique is widely used, but has been associated with a risk of graft damage. The Press-Fit-Hybrid®-technique is one of the alternatives for biological ACL-reconstruction with minimal implant requirements. The hypothesis of this retrospective analysis is, that the Press-Fit-Hybrid®-technique leads to better results with respect to re-rupture rate and secondary meniscal lesion than the interference-screw-technique.

Methods
To compare the re-rupture rate of the interference-screw-technique (IF) used until 2015 with the currently used Press-Fit-Hybrid®-technique (PFH), the last 100 patients of the IF-group and the first 100 patients of the PFH-group were retrospectively analyzed. Primary outcomes were re-rupture rate, complications and secondary meniscal injury. Additionally, laxity, Lachman and Pivot-shift and range of motion were evaluated.

Results
A mean follow-up of 4.2 and 5.3 years revealed 4% and 9% re-rupture rates and 1% and 2% complication rates in the PFH- and IF-group, respectively. In the PFH-group there were no re-ruptures in patients older than 23 years. Secondary meniscal injury post-surgery was 6% and 9% for the PFH and IF-group, respectively. Knee stability was similar in both groups. Range of motion was significantly better in the PFH-group, with 136° of flexion, 6 months after surgery.

Conclusion
For ACL-reconstruction the Press-Fit-Hybrid®-technique is an alternative new method. Low level of secondary meniscal lesions after surgery and high stability, is known to prevent later arthrosis of the knee. The encouraging observed trend of the reduction of the re-rupture rate in revision surgery and in young patients using the Press-Fit-Hybrid®-technique in comparison to the interference-screw-technique must be confirmed with further studies.

Level of evidence
Therapeutic Level III, retrospective cohort study.
Influence of AFP on surgical outcomes in non-B non-C patients with curative resection for hepatocellular carcinoma
Authors: Tan Xiao-ping , Zhou Kai , Zeng Qing-li , Yuan Yun-fei , Chen Wei 
Published: March 2022

AbstractTo study the clinical and prognostic features of non-B non-C alpha-fetoprotein (AFP)(-)-hepatocellular carcinoma (HCC) (NBNC-AFP(-)-HCC) and the relationship between the prognostic features of HCC and hepatitis B virus surface antigen (HBsAg) status and AFP. We enrolled 227 patients who underwent hepatic resection for HCC between January 1998 and December 2007 at Sun Yat-sen University Cancer Center, all of whom were diagnosed with HCC by pathology. All patients were stratified into one of four groups (B-AFP(+)-HCC, B-AFP(-)-HCC, NBNC-AFP(+)-HCC, and NBNC-AFP(-)-HCC) according to AFP levels and HBsAg status. The clinicopathologic and survival characteristics of NBNC-AFP(-)-HCC patients were compared with those of all other three groups. Out of the 105 NBNC-HCC patients, 43 patients (40.9%) had AFP-negative HCC. There were some differences in factors between the B-AFP(+) and NBNC-AFP(-) patients, such as age, body mass index (BMI), diabetes, and ALT (P < 0.05). On univariate analysis, tumour size, secondary tumour, and portal invasion were prognostic factors for overall survival (OS) and disease-free survival (DFS) (P < 0.05). Cox multivariate regression analysis suggested that tumour size and tumour number (P < 0.05) were independent predictors. In addition, compared with the B-AFP(+)-HCC, B-AFP(-)-HCC, and NBNC-AFP(+)-HCC groups, the NBNC-AFP(-)-HCC patients had the best DFS (P < 0.05). Compared with the B-AFP(+)-HCC and NBNC-AFP(+)-HCC groups, the NBNC-AFP(-)-HCC patients had better OS (P < 0.05), and survival rates were similar to those of B-AFP(-)-HCC patients. NBNC-AFP(-)-HCC patients had a relatively favourable prognosis. It can serve as a useful marker in predicting the risk of tumour recurrence in the early stages.
Combined Features in Region of Interest for Brain Tumor Segmentation
Authors: Alqazzaz Salma , Sun Xianfang , Nokes Len DM , Yang Hong , Yang Yingxia , Xu Ronghua , Zhang Yanqiang , Yang Xin 
Published: March 2022

AbstractDiagnosis of brain tumor gliomas is a challenging task in medical image analysis due to its complexity, the less regularity of tumor structures, and the diversity of tissue textures and shapes. Semantic segmentation approaches using deep learning have consistently outperformed the previous methods in this challenging task. However, deep learning is insufficient to provide the required local features related to tissue texture changes due to tumor growth. This paper designs a hybrid method arising from this need, which incorporates machine-learned and hand-crafted features. A semantic segmentation network (SegNet) is used to generate the machine-learned features, while the grey-level co-occurrence matrix (GLCM)-based texture features construct the hand-crafted features. In addition, the proposed approach only takes the region of interest (ROI), which represents the extension of the complete tumor structure, as input, and suppresses the intensity of other irrelevant area. A decision tree (DT) is used to classify the pixels of ROI MRI images into different parts of tumors, i.e. edema, necrosis and enhanced tumor. The method was evaluated on BRATS 2017 dataset. The results demonstrate that the proposed model provides promising segmentation in brain tumor structure. The F-measures for automatic brain tumor segmentation against ground truth are 0.98, 0.75 and 0.69 for whole tumor, core and enhanced tumor, respectively.
Feather stable isotopes (δ2Hf and δ13Cf) identify the Sub-Saharan wintering grounds of turtle doves from Europe
Authors: Marx Melanie , Schumm Yvonne R. , Kardynal Kevin J. , Hobson Keith A. , Rocha Gregorio , Zehtindjiev Pavel , Bakaloudis Dimitris , Metzger Benjamin , Cecere Jacopo G. , Spina Fernando , Cianchetti-Benedetti Marco , Frahnert Sylke , Voigt Christian C. , Lormée Hervé , Eraud Cyril , Quillfeldt Petra 
Published: March 2022

AbstractConservation of migratory birds requires knowledge of breeding and nonbreeding ranges and the connections between them. European turtle doves (Streptopelia turtur) are Palearctic-African long-distance migrants with wintering areas in the Sub-Saharan belt that are classed as vulnerable due to strong population declines. However, detailed non-breeding locations of individuals from different migratory flyways are unknown. To identify wintering regions of turtle doves, we measured stable isotopes of feathers grown on the wintering grounds and used a dual-isotope (hydrogen (δ2Hf) and carbon (δ13Cf)) probabilistic assignment to analyse origins of individuals migrating through the western and central/eastern flyways. The most probable wintering areas for turtle dove samples from both flyways were in the western and central Sub-Sahara. However, we found differences in δ2Hf and δ13Cf values between turtle doves following different migratory routes (western vs central/eastern flyway). This result suggests a higher likelihood of origins in the central Sub-Sahara for central and eastern migrants, while turtle doves using the western flyway originated primarily in the western Sub-Sahara, highlighting the importance of both regions for the future conservation of turtle doves from European breeding populations. The establishment of migratory connectivity of populations requires sampling from birds from the European as well as Asian continent; however, we provide important results that can be used to test hypotheses regarding population declines resulting from factors experienced over the full annual cycle for some populations.
Associations Between Anxiety and Home Learning Difficulties in Children and Adolescents with ADHD During the COVID-19 Pandemic
Authors: Jackson Anna , Melvin Glenn A. , Mulraney Melissa , Becker Stephen P. , Bellgrove Mark A. , Quach Jon , Hutchinson Delyse , Westrupp Elizabeth M. , Montgomery Alicia , Sciberras Emma 
Published: March 2022

AbstractThe COVID-19 pandemic has markedly impacted functioning for children and adolescents including those with attention-deficit/hyperactivity disorder (ADHD). We explored home learning difficulties (HLD) during COVID-19 restrictions in Australian children (aged 5–17) with ADHD, aiming to: (1) describe home learning experiences, and (2) examine associations between child anxiety (i.e., concurrent anxiety symptoms and pre-existing anxiety disorder status) and HLD. Baseline data from the longitudinal ADHD COVID-19 Survey were used (n = 122). Parents reported on school factors and HLD; pre-existing anxiety and co-occurring difficulties; anxiety, ADHD, and oppositional symptoms; demographics; and medications. Parents retrospectively reported more children often looked forward to school pre-pandemic, than during the pandemic. Anxiety symptoms, but not pre-existing anxiety disorder status, were associated with HLD after accounting for covariates. ADHD inattention symptoms were also associated with HLD. Results support recommendations to continue pre-pandemic supports to assist with ADHD symptoms during home learning, and strategies/supports for families are discussed.
Elevated CD21low B Cell Frequency Is a Marker of Poor Immunity to Pfizer-BioNTech BNT162b2 mRNA Vaccine Against SARS-CoV-2 in Patients with Common Variable Immunodeficiency
Authors: Bergman Peter , Wullimann David , Gao Yu , Wahren Borgström Emilie , Norlin Anna-Carin , Lind Enoksson Sara , Aleman Soo , Ljunggren Hans-Gustaf , Buggert Marcus , Smith C. I. Edvard 
Published: March 2022

AbstractPurposeLimited data is available on the effect of COVID-19 vaccination in immunocompromised individuals. Here, we provide the results from vaccinating a single-center cohort of patients with common variable immunodeficiency (CVID).MethodsIn a prospective, open-label clinical trial, 50 patients with CVID and 90 age-matched healthy controls (HC) were analyzed for SARS-CoV-2 spike antibody (Ab) production after one or two doses of the Pfizer-BioNTech BNT162b2 mRNA vaccine. Additionally, in selected patients, SARS-CoV-2 spike-specific T-cells were assessed.ResultsA potent vaccine-induced anti-spike–specific IgG Ab response was observed in all the HC. In contrast, only 68.3% of the CVID patients seroconverted, with median titers of specific Ab being 83-fold lower than in HC. In fact, only 4/46 patients (8.6%) of patients who were seronegative at baseline reached the threshold for an optimal response (250 U/mL). Using the EUROclass definition, patients with either a reduced proportion, but not absolute counts, of switched memory B-cells or having an increased frequency of CD21lowB-cells generally generated poor vaccine responses. Overall, CVID-patients had reduced spike-specific IFN-γ positive CD4+T cell responses 2 weeks after the second dose, compared to HC. The total CD4 and CD4 central memory cell counts correlated with humoral immunity to the vaccine.ConclusionsCVID patients with low frequency of switched memory B-cells or an increased frequency of CD21lowB-cells according to the EUROclass definition demonstrated poor responses to Pfizer-BioNTech BNT162b2 mRNA vaccination. Cellular immune responses were significantly affected, affirming that the defect in CVID is not limited to humoral immunity.
Gravity from Symmetry Breaking Phase Transition
Authors: Volovik G. E. 
Published: March 2022

AbstractThe paper is devoted to the memory of Dmitry Diakonov. We discuss gravity emerging in the fermionic vacuum as suggested by Diakonov 10 years ago in his paper “Towards lattice-regularized Quantum Gravity”. [1] Gravity emerges in the phase transition. The order parameter in this transition is the tetrad field $$e^a_\mu$$

e
μ
a

, which appears as the bilinear composite of the fermionic fields. The similar scenario of the symmetry breaking takes place in the B-phase of superfluid $$^3$$

3

He, where the real part of the spin-triplet p-wave order parameter matrix $$A_{a i}$$

A

ai

plays the role of the emerging tetrad (triad). In Diakonov theory this symmetry breaking gives 6 Nambu-Goldstone modes; 6 gauge bosons in the spin-connection fields, which absorb 6 NG modes and become massive gauge bosons; and 6 Higgs fields. In $$^3$$

3

He-B, these Higgs collective modes correspond to 6 massive gravitons, while in the emerging general relativity the Higgs collective modes give rise to two massless gravitational waves.
Moral Injury, Chaplaincy and Mental Health Provider Approaches to Treatment: A Scoping Review
Authors: Jones Kimberley A. , Freijah Isabella , Carey Lindsay , Carleton R. Nicholas , Devenish-Meares Peter , Dell Lisa , Rodrigues Sara , Madden Kelsey , Johnson Lucinda , Hosseiny Fardous , Phelps Andrea J. 
Published: March 2022

AbstractThe aim of this research was to describe the evidence examining the approaches taken by mental health providers (MHPs) and chaplains to address symptoms related to moral injury (MI) or exposure to potentially morally injurious events (PMIEs). This research also considers the implications for a holistic approach to address symptoms related to MI that combines mental health and chaplaincy work. A scoping review of literature was conducted using Medline, PsycINFO, Embase, Central Register of Controlled Trials, Proquest, Philosphers Index, CINAHL, SocINDEX, Academic Search Complete, Web of Science and Scopus databases using search terms related to MI and chaplaincy approaches or psychological approaches to MI. The search identified 35 eligible studies: 26 quantitative studies and nine qualitative studies. Most quantitative studies (n = 33) were conducted in military samples. The studies examined interventions delivered by chaplains (n = 5), MHPs (n = 23) and combined approaches (n = 7). Most studies used symptoms of post-traumatic stress disorder (PTSD) and/or depression as primary outcomes. Various approaches to addressing MI have been reported in the literature, including MHP, chaplaincy and combined approaches, however, there is currently limited evidence to support the effectiveness of any approach. There is a need for high quality empirical studies assessing the effectiveness of interventions designed to address MI-related symptoms. Outcome measures should include the breadth of psychosocial and spiritual impacts of MI if we are to establish the benefits of MHP and chaplaincy approaches and the potential incremental value of combining both approaches into a holistic model of care.
Landscapes for Neolithic People in Mainland, Orkney
Authors: Bunting M. Jane , Farrell Michelle , Dunbar Elaine , Reimer Paula , Bayliss Alex , Marshall Peter , Whittle Alasdair 
Published: March 2022

AbstractNeolithic occupation of the Orkney Islands, in the north of Scotland, probably began in the mid fourth millennium cal BC, culminating in a range of settlements, including stone-built houses, varied stone-built tombs and two noteworthy stone circles. The environmental and landscape context of the spectacular archaeology, however, remains poorly understood. We applied the Multiple Scenario Approach (MSA) to Neolithic pollen records from Mainland, Orkney, in order to understand land cover and landscape openness across the timespan 4200–2200 cal BC. Interpreted within a framework provided by Bayesian chronological modelling, 406 radiocarbon dates from archaeological contexts and a further 103 from palaeoenvironmental samples provide the basis for the first detailed reconstruction of the spatio-temporal patterns of Neolithic people and their environment. Major alterations to the land cover of Mainland took place from 3400 cal BC (reduction in woodland from 20% to 10%) and from 3200 cal BC (increase in disturbed land from 3% to 30%). The dramatic increase in disturbed land coincided with the Grooved Ware phenomenon and the establishment of settlements at Skara Brae and Ness of Brodgar. The upturn in the signal for disturbance communities in the pollen record may indicate an increase in the amount of land used as pasture. This accords with the archaeological record, since the Neolithic Orcadian economy probably relied heavily on cattle for subsistence. By 2800 cal BC in the core of the Orkney Mainland, most settlements appear to have been ending, with people dispersing into the wider landscape, as the MSA modelling indicates a maintenance of disturbed land, and indeed a subsequent slight increase, implying persistence of human activity elsewhere in Mainland. People exhausted themselves rather than their land; that and its varied resources endured, while the intensive social relationships and practices of the peak of late Neolithic Orkney could not be maintained.
Approximate recoverability and relative entropy II: 2-positive channels of general von Neumann algebras
Authors: Faulkner Thomas , Hollands Stefan 
Published: March 2022

AbstractWe generalize our results in paper I in this series to quantum channels between general von Neumann algebras, proving the approximate recoverability of states which undergo a small change in relative entropy through the channel. To this end, we derive a strengthened form of the quantum data processing inequality for the change in relative entropy of two states under a channel between two von Neumann algebras. Compared to the usual inequality, there is an explicit lower bound involving the fidelity between the original state and a recovery channel.
Primary donor triplet states of Photosystem I and II studied by Q-band pulse ENDOR spectroscopy
Authors: Niklas Jens , Agostini Alessandro , Carbonera Donatella , Di Valentin Marilena , Lubitz Wolfgang 
Published: March 2022

AbstractThe photoexcited triplet state of the “primary donors” in the two photosystems of oxygenic photosynthesis has been investigated by means of electron-nuclear double resonance (ENDOR) at Q-band (34 GHz). The data obtained represent the first set of1H hyperfine coupling tensors of the3P700 triplet state in PSI and expand the existing data set for3P680. We achieved an extensive assignment of the observed electron-nuclear hyperfine coupling constants (hfcs) corresponding to the methine α-protons and the methyl group β-protons of the chlorophyll (Chl) macrocycle. The data clearly confirm that in both photosystems the primary donor triplet is located on one specific monomeric Chl at cryogenic temperature. In comparison to previous transient ENDOR and pulse ENDOR experiments at standard X-band (9–10 GHz), the pulse Q-band ENDOR spectra demonstrate both improved signal-to-noise ratio and increased resolution. The observed ENDOR spectra for3P700 and3P680 differ in terms of the intensity loss of lines from specific methyl group protons, which is explained by hindered methyl group rotation produced by binding site effects. Contact analysis of the methyl groups in the PSI crystal structure in combination with the ENDOR analysis of3P700 suggests that the triplet is located on the Chlaʹ (PA) in PSI. The results also provide additional evidence for the localization of3P680 on the accessory ChlD1in PSII.
Optimal Bayesian design for model discrimination via classification
Authors: Hainy Markus , Price David J. , Restif Olivier , Drovandi Christopher 
Published: March 2022

AbstractPerforming optimal Bayesian design for discriminating between competing models is computationally intensive as it involves estimating posterior model probabilities for thousands of simulated data sets. This issue is compounded further when the likelihood functions for the rival models are computationally expensive. A new approach using supervised classification methods is developed to perform Bayesian optimal model discrimination design. This approach requires considerably fewer simulations from the candidate models than previous approaches using approximate Bayesian computation. Further, it is easy to assess the performance of the optimal design through the misclassification error rate. The approach is particularly useful in the presence of models with intractable likelihoods but can also provide computational advantages when the likelihoods are manageable.