bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiviral Activity of Selected Lamiaceae Essential Oils and Their Monoterpenes Against SARS-Cov-2
Authors: Ćavar Zeljković Sanja , Schadich Ermin , Džubák Petr , Hajdúch Marián , Tarkowski Petr 
Published: May 2022

This study presents the very first report on the in vitro antiviral activity of selected essential oils of Lamiaceae plant species and their monoterpenes against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nineteen essential oils were obtained by hydrodistillation of dried plant material, and their monoterpene profiles were determined. In addition, the exact concentrations of each monoterpene that were found at a significant level were defined. Both essential oils and their monoterpene components were tested for cytotoxic and antiviral activity against SARS-CoV-2 in infected Vero 76 cells. The results showed that the essential oils of four Mentha species, i.e., M. aquatica L. cv. Veronica, M. pulegium L., M. microphylla K.Koch, and M. x villosa Huds., but also Micromeria thymifolia (Scop.) Fritsch and Ziziphora clinopodioides Lam., and five different monoterpenes, i.e., carvacrol, carvone, 1,8-cineol, menthofuran, and pulegone, inhibited the SARS-CoV-2 replication in the infected cells. However, the antiviral activity varied both among essential oils and monoterpenes. Carvone and carvacrol exhibited moderate antiviral activity with IC50 concentrations of 80.23 ± 6.07 μM and 86.55 ± 12.73 μM, respectively, while the other monoterpenes were less active (IC50 &gt; 100.00 μM). Structure-activity relations of related monoterpenes showed that the presence of keto and hydroxyl groups is associated with the activity of carvone and carvacrol, respectively. Furthermore, the carvone-rich essential oil of M. x villosa had the greatest activity among all active essential oils (IC50 127.00 ± 4.63 ppm) while the other active oils exhibited mild (140 ppm &lt; IC50 &lt; 200 ppm) to weak antiviral activity (IC50 &gt; 200 ppm). Both essential oils and monoterpenes showed limited or no cytotoxicity against Vero 76 cells. Hierarchical cluster analysis showed that the differences in the antiviral activity of essential oils were directly attributed to the antiviral efficacies of their particular single monoterpenes. The findings presented here on the novel antiviral property of plant essential oils and monoterpenes might be used in the development of different measures against SARS-CoV-2.
Glycosylation of Zein Hydrolysate as a Nanocarrier for Lutein Delivery: Preparation and Stability
Authors: Han He , Jiao Yan , Chang Ying , Cheng Yue , Shi Lei 
Published: May 2022

Lutein is a functional carotenoid that has a wide range of physiological benefits in humans. However, it easily degrades and becomes inactivated during storage and processing, resulting in low bioavailability. The development of new nanocarriers can effectively improve the stability and biological activity of lutein. In this study, zein hydrolysate (ZH) carriers were glycosylated with glucosamine (GLU) under the action of transglutaminase, and lutein-loaded glycosylated ZH nanoparticles (GZH-LUT) were constructed by liquid–liquid dispersion. The results showed that the GZH-LUT particles had a narrow size distribution in the range of 200–300 nm and a decreased zeta potential and polydispersity index. In particular, GZH trapped lutein more efficiently than ZH. In addition, GZH-LUT had better physical and chemical properties, including better water solubility, oxidative stability, and environmental stability than free lutein and ZH-LUT. These results indicate that glycosylated zein hydrolysate has the potential to be used as a novel protein-based nanocarrier to enhance the solubility and stability of lutein, which can further improve its bioavailability.
In Vivo Characterization of a Red Light-Activated Vasodilation: A Photobiomodulation Study
Authors: Keszler Agnes , Lindemer Brian , Broeckel Grant , Weihrauch Dorothee , Gao Yan , Lohr Nicole L. 
Published: May 2022

Nitric oxide dependent vasodilation is an effective mechanism for restoring blood flow to ischemic tissues. Previously, we established an ex vivo murine model whereby red light (670 nm) facilitates vasodilation via an endothelium derived vasoactive species which contains a functional group that can be reduced to nitric oxide. In the present study we investigated this vasodilator in vivo by measuring blood flow with Laser Doppler Perfusion imaging in mice. The vasodilatory nitric oxide precursor was analyzed in plasma and muscle with triiodide-dependent chemiluminescence. First, a 5–10 min irradiation of a 3 cm2 area in the hind limb at 670 nm (50 mW/cm2) produced optimal vasodilation. The nitric oxide precursor in the irradiated quadriceps tissue decreased significantly from 123 ± 18 pmol/g tissue by both intensity and duration of light treatment to an average of 90 ± 17 pmol/g tissue, while stayed steady (137 ± 21 pmol/g tissue) in unexposed control hindlimb. Second, the blood flow remained elevated 30 min after termination of the light exposure. The nitric oxide precursor content significantly increased by 50% by irradiation then depleted in plasma, while remained stable in the hindlimb muscle. Third, to mimic human peripheral artery disease, an ameroid constrictor was inserted on the proximal femoral artery of mice and caused a significant reduction of flow. Repeated light treatment for 14 days achieved steady and significant increase of perfusion in the constricted limb. Our results strongly support 670 nm light can regulate dilation of conduit vessel by releasing a vasoactive nitric oxide precursor species and may offer a simple home-based therapy in the future to individuals with impaired blood flow in the leg.
Case Report: A Case of Valproic Acid-Induced Hyperammonemic Encephalopathy Associated With the Initiation of Lithium: A Re-duplicable Finding
Authors: Levy Anna , Very Etienne , Montastruc François , Birmes Philippe , Jullien Adeline , Richaud Louis 
Published: May 2022

IntroductionHyperammonemic encephalopathy (HAE) is a serious adverse effect of valproate semisodium, which is facilitated by the potential for drug interaction. However, despite frequent co-prescription of valproate semisodium and lithium, the role of this combination in the occurrence of HAE has not been defined in the literature. This case report concerns the occurrence of HAE concomitant with the initiation of lithium in a 29-year-old patient who had been placed on valproate semisodium for a schizoaffective disorder.Case ReportDue to a relapse while on a combined antipsychotic and mood-stabilizing therapy (paliperidone palmitate and valproate semisodium), a cross-taper from valproate semisodium to lithium was proposed. The initiation of lithium was accompanied by an acute confusional syndrome, an elevated serum valproate level and hyperammonemia suggestive of drug-induced HAE. The discontinuation of lithium and reduction of valproate semisodium led to neurological improvement, until a recrudescence of psychiatric symptoms justified a rechallenge of the combination within the framework of a new cross-taper. As soon as Lithium was re-initiated, an increase in the serum valproate level and hyperammonemia were again noted.DiscussionThe mechanisms of valproate-related HAE involve various metabolic pathways. In this case, exploration of the iatrogenic hypothesis focused on the imputability of concomitant cannabis use and co-prescriptions of benzodiazepines, antipsychotics, and in all likelihood, mood stabilizers.ConclusionTherefore, this case study suggests that Lithium plays a role in serum valproate level elevation, and supports the hypothesis of an association between an elevated serum valproate level, hyperammonemia and reversible encephalopathy. A more in-depth pharmacokinetic exploration would provide a better understanding of the mechanisms of these interactions and support for the benefit-risk balance associated with this frequent co-prescription.
Online One-Stop Shop for Disaster Response Services After the MH17 Airplane Crash: An Evaluation Study
Authors: van Herpen Merel M. , Dückers Michel L. A. , Schaap Rick , Olff Miranda , te Brake Hans 
Published: May 2022

BackgroundA one-stop shop for disaster response services provides a central location for information and advice in an accessible way. Yet little is known about its organization and outcomes. After the MH17 airplane crash, the one-stop shop concept was realized through a digital environment called the Information and Referral Center (IRC). The aim of this study was to evaluate the experiences of users and providers in regard to the IRC and to identify improvement points for future IRCs.MethodData was collected among affected ones as well as involved organizations, using interviews, focus groups, surveys and online user information. Existing evaluation and quality models were combined to design the study and analyze the data.ResultsFirst, affected ones and a variety of organizations involved were positive about the merits of the IRC. Affected ones indicated they perceived the IRC as a reliable source of information and appreciated the referral possibilities. Second, the feature of the IRC to serve as a community where affected ones could meet, share experiences and support each other was hardly used according to participants. Lastly, tracking evolving psychosocial needs and problems through the IRC was hampered due to difficulty in accessing relevant data.ConclusionsThe IRC helped organizations to structure and align their services. Affected ones were positive about its reliability and accessibility. An IRC has to be embedded within the established care structures. Future research could indicate whether an IRC is useful in other event types and population contexts as well.
Development and Internal Validation of Supervised Machine Learning Algorithm for Predicting the Risk of Recollapse Following Minimally Invasive Kyphoplasty in Osteoporotic Vertebral Compression Fractures
Authors: Dong Sheng-tao , Zhu Jieyang , Yang Hua , Huang Guangyi , Zhao Chenning , Yuan Bo 
Published: May 2022

BackgroundThe published literatures indicate that patients with osteoporotic vertebral compression fractures (OVCFs) benefit significantly from percutaneous kyphoplasty (PKP), but this surgical technique is associated with frequent postoperative recollapse, a complication that severely limits long-term postoperative functional recovery.MethodsThis study retrospectively analyzed single-segment OVCF patients who underwent bilateral PKP at our academic center from January 1, 2017 to September 30, 2019. Comparing the plain films of patients within 3 days after surgery and at the final follow-up, we classified patients with more than 10% loss of sagittal anterior height as the recollapse group. Univariate and multivariate logistic regression analyses were performed to determine the risk factors affecting recollapse after PKP. Based on the logistic regression results, we constructed one support vector machine (SVM) classifier to predict recollapse using machine learning (ML) algorithm. The predictive performance of this prediction model was validated by the receiver operating characteristic (ROC) curve, 10-fold cross validation, and confusion matrix.ResultsAmong the 346 consecutive patients (346 vertebral bodies in total), postoperative recollapse was observed in 40 patients (11.56%). The results of the multivariate logistical regression analysis showed that high body mass index (BMI) (Odds ratio [OR]: 2.08, 95% confidence interval [CI]: 1.58–2.72, p &lt; 0.001), low bone mineral density (BMD) T-scores (OR: 4.27, 95% CI: 1.55–11.75, p = 0.005), presence of intravertebral vacuum cleft (IVC) (OR: 3.10, 95% CI: 1.21–7.99, p = 0.019), separated cement masses (OR: 3.10, 95% CI: 1.21–7.99, p = 0.019), cranial endplate or anterior cortical wall violation (OR: 0.17, 95% CI: 0.04–0.79, p = 0.024), cement-contacted upper endplate alone (OR: 4.39, 95% CI: 1.20–16.08, p = 0.025), and thoracolumbar fracture (OR: 6.17, 95% CI: 1.04–36.71, p = 0.045) were identified as independent risk factors for recollapse after a kyphoplasty surgery. Furthermore, the evaluation indices demonstrated a superior predictive performance of the constructed SVM model, including mean area under receiver operating characteristic curve (AUC) of 0.81, maximum AUC of 0.85, accuracy of 0.81, precision of 0.89, and sensitivity of 0.98.ConclusionsFor patients with OVCFs, the risk factors leading to postoperative recollapse were multidimensional. The predictive model we constructed provided insights into treatment strategies targeting secondary recollapse prevention.
Pediatric Chronic Pain, Resilience and Psychiatric Comorbidity in Canada: A Retrospective, Comparative Analysis
Authors: Young Megan A. , Anang Polina , Gavalova Anna 
Published: May 2022

ObjectiveChronic pain compromises child and adolescent well-being and development. This study aimed to identify risk factors for chronic pain and exploration of how young people negotiate such risks and express resilience. We hypothesized children and youth with chronic pain would report greater prevalence of mental health disorders than the general population; and those demonstrating greater resilience would demonstrate less psychiatric comorbidity.MethodA retrospective chart review was conducted for all patients (ages 7–17) attending the sole pediatric chronic pain clinic in Manitoba, from 2015 to 2019 (N = 116). Patients' demographic information and psychiatric illness burden were compared to provincial epidemiological data using Chi-Square tests. Pain sites, family history, psychiatric illness, psychosocial functioning, treatment history and treatment recommendations were explored.ResultsThe sample was predominantly female (74%; N = 114). Sixty-eight percent of patients reported a family history of chronic pain. Thirty-seven percent of the patients (vs. 14.0% anticipated; N = 326 260) reported comorbid psychiatric disorder, X2 (1, N = 114) = 53.00, p &lt; 0.001. Thirty-two percent reported diagnosis of mood and/or anxiety disorder (vs. 7.3%), X2 (1, N = 114) = 99.34, p &lt; 0.001. Children and youth demonstrating resilience through engagement in more prosocial behaviors reported fewer psychiatric symptoms (rs = −0.292, N = 114, p = 0.002, Spearman's correlation).ConclusionsFemale sex, family history, and lower socioeconomic status were associated with chronic pain. Psychiatric conditions were more prevalent in chronic pain patients than in the general population. Approaching chronic pain from a mind-body perspective, while building on patients' strengths, is central to informing treatment.
On the Problems and Methods for International Comparisons of GDP
Authors: Ivanov Yu. N. 
Published: May 2022

The introductory part of the article argues the relevance of continuing research on the conceptual and methodological problems of international comparisons of macroeconomic indicators due to begging of new round of the International Comparison Program (ICP) of GDP by Purchasing Power Parities (PPPs), designed to build unique science-based systems of statistical data on the world economy and the place of each country in it.The body of the article formulates the author's view of the basic methodological approaches to international comparisons of macroeconomic indicators; it also focuses on several areas for improving the quality of international statistics. It is argued that to improve the quality of international comparisons, there is a particular need to implement in the national statistical practice of individual countries the methodological procedures for measuring the following main economic transactions: research and development expenditure, government expenditure on the acquisition of weapons systems, imputed output of financial intermediation services, updated in the 2008 SNA. The paper explains the need for updating some purchasing power parities methodology provisions and postulates, especially those concerning non-market government services. According to the author, it would be beneficial to continue the debate on the merits and limitations of the Elteto, Koves and Szulc (EKS) method and the Geary – Khamis method.The conclusion is that the development of standards for international comparisons of PPP-based GDP will be in the interests of the governments across the world, national central banks, international organizations, and, of course, will contribute to solving modern problems in national socio-economic statistics and Russian statistics, in particular.
Supporting Employees’ Participation in Sports: Statistical and Sociological Study
Authors: Zasimova L. S. , Makshanchikov K. N. 
Published: May 2022

The article reflects results of empirical analysis of sport incentives for working adults in Russia. The study uses data from a small, but according to the authors, representative sample (2208 employees) of Russian adults’ attitudes towards their health and quality of medical care in Russian Federation. The survey was initiated by the National Research University Higher School of Economics in 2017, before the start of COVID-19 pandemic, which for a certain period disrupted the employees’ measures promoting sports for their workers. However, the relevance of the study has been fully preserved. The authors not just give a snapshot of sport-promoting measures adopted by Russian enterprises, but also justify the methodology for statistical analysis of a healthy lifestyle policies provided by employers to their employees.The paper reports the main parameters and the content of the population survey used in the study; describes main sport participation indicators and its’ determinants; presents estimates of factors attributed to sport participation among working adults. More specifically, the authors study the stimulating effect of two popular measures to encourage sport participation in Russian enterprises: providing access to sport infrastructure at the worksites and subsidies for practicing sport in sport centers.Using descriptive and econometric analyzes, the authors investigate the association between sport-encouraging measures and working adults sporting activity, estimate statistical significance of this relationship. In order to concretize and deepen the empirical analysis of sport participation among working adults, the authors adjust their analyses by adding such respondents’ characteristics as gender, age, health status, smoking status, education, type of work and place of residency.The study shows that probability of sport participation is much higher for those who has access to sport infrastructure at their worksites (for both men and women). However, employers’ subsidies for sport activity outside working places is not associated with any increase in the probability of doing sports.
A Deep Learning Approach for Detecting Colorectal Cancer via Raman Spectra
Authors: Cao Zheng , Pan Xiang , Yu Hongyun , Hua Shiyuan , Wang Da , Chen Danny Z. , Zhou Min , Wu Jian 
Published: May 2022

Objective and Impact Statement.
Distinguishing tumors from normal tissues is vital in the intraoperative diagnosis and pathological examination. In this work, we propose to utilize Raman spectroscopy as a novel modality in surgery to detect colorectal cancer tissues.
Introduction.
Raman spectra can reflect the substance components of the target tissues. However, the feature peak is slight and hard to detect due to environmental noise. Collecting a high-quality Raman spectroscopy dataset and developing effective deep learning detection methods are possibly viable approaches.
Methods.
First, we collect a large Raman spectroscopy dataset from 26 colorectal cancer patients with the Raman shift ranging from 385 to 1545 cm

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. Second, a one-dimensional residual convolutional neural network (1D-ResNet) architecture is designed to classify the tumor tissues of colorectal cancer. Third, we visualize and interpret the fingerprint peaks found by our deep learning model.
Results.
Experimental results show that our deep learning method achieves 98.5% accuracy in the detection of colorectal cancer and outperforms traditional methods.
Conclusion.
Overall, Raman spectra are a novel modality for clinical detection of colorectal cancer. Our proposed ensemble 1D-ResNet could effectively classify the Raman spectra obtained from colorectal tumor tissues or normal tissues.
Mortgage lending market in Russia in terms of exit out of the pandemic
Authors: Koniagina M. N. , Khashaev A. A. 
Published: May 2022

Aim. The work aimed to summarize the results of the development of the mortgage lending market during the acute phase of the COVID-19 pandemic and predict its development in the near future.Tasks. The work was performed to investigate the volume of issuance and growth rates of mortgage lending in Russia; to analyze the dynamics of the total mortgage portfolio of the banking system of the Russian Federation (RF), as well as the average cost of 1 square meter of housing in the primary and secondary markets in a pandemic, combined with government support; demonstrate possible changes in the Russian mortgage market during the exit out of the COVID-19 pandemic and consequences of the implementation of state market support programs.Methods. The methodological foundation of the study was the general scientific methods of cognition, namely analysis, synthesis, generalization, visualization, and forecasting. In particular, the authors analyzed the indicators of the mortgage lending and real estate markets, identified causal relationships between the state support for mortgage lending and changes in the main parameters of the real estate market, as well as forecasting the dynamics of its individual indicators.Results. The work presents the main indicators characterizing mortgage lending in Russia from 2014 to the present time, including the aggregate mortgage portfolio of Russian banks. The study describes the average cost of 1 square meter of housing in the primary and secondary markets. The authors of the article predicted changes in the mortgage lending market, the state of the quality of bank loan portfolios and trends in the residential real estate market as a whole.Conclusion. Under conditions of the COVID-19 pandemic, mortgage lending has shown its incredible growth in association with government support. However, according to the authors, there will be significant changes in the future, which will be the consequences of such a rapid development, namely an increase in overdue indebtedness on mortgage loans, a shortage of demand for built housing which has sharply become expensive. Banks will be forced to tighten monitoring of mortgage programs and select carefully new borrowers, ensuring their highest quality.
The Result of Stress Management Program in Freshman Nursing Students
Authors: Bunluesup Worawalun , Pongklum Orapen , Pakluck Pannee , Khuttamasoon Tunyawan 
Published: May 2022

This quasi-experimental research aimed to study stress level and the result of stress management program of freshmen nursing students. Simple random sampling technique was used to select 60 freshmen nursing students. They are divided equally into control group and intervention group. Stress management program was developed by investigators and implemented in the intervention group for 3 weeks. Stress level was assessed in both groups before and after the implementation in the intervention group by using Suanprung Stress Test-20 which is a standardized test with Cronbach’s Alpha of .87. Descriptive and Independent t-test were performed in statistical analysis. The results revealed that high level of stress in both groups (p < .05) before the intervention. However, the stress level of freshmen students who receive stress management program in the intervention group decreases (t = 2.20, p < .05). These findings suggest that instructors and administrators should develop and promote mental health activities for nursing students.