bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introducing the Government-Sponsored Mass Expulsion Dataset
Authors: Garrity Meghan 
Published: June 2022

This article introduces the Government-Sponsored Mass Expulsion (GSME) dataset documenting cross-border mass expulsion episodes around the world from 1900 to 2020. This new dataset focuses on mass expulsion policies in which governments systematically remove ethnic, racial, religious or national groups, en masse. The GSME dataset disaggregates mass expulsion from other exclusionary politics concepts to isolate policies of intentional group-based population removal. This allows for a systematic examination of governmental expulsion policies, distinct from policies aimed at annihilation (genocide), control (massacre) or cultural elimination (coercive assimilation). The GSME dataset documents 139 expulsion episodes since 1900, affecting over 30 million citizens and non-citizens across all world regions. The data are drawn from archival research conducted at the United Nations High Commissioner for Refugees and the International Committee of the Red Cross, as well as secondary sources and extant datasets. This article presents an empirical overview of the data including information on the expelling country, onset, duration, region, scale, category of persons expelled, and frequency. Although mass expulsion is a rare event, it is a reoccurring rare event. Its consistent use – with over two million people expelled in the last five years alone – demands additional empirical and theoretical investigation. The GSME dataset contributes to the study of exclusionary politics as a dependent variable, but it also offers promise as an explanatory variable for those studying phenomena affected by mass expulsion.
Association of renal surface nodularity with arterial hypertension compared to normotensive patients
Authors: Ding Jiule , Zhou Jun , Wang Kaixiang , Jiang Zhenxing , Xing Wei 
Published: June 2022

Background Renal surface nodularity (RSN) is a subclinical biomarker of renal injury and may be associated with arterial hypertension. Purpose To explore the association of RSN with arterial hypertension compared to normotensive patients. Material and Methods A total of 205 inpatients with or without high blood pressure (HBP vs. control group) who underwent abdominal computed tomography (CT) scans were included. Their clinical characteristics included age, sex, HBP course, HBP grade, history of diabetes mellitus (DM), and renal function (estimated glomerular filtration rate [eGFR]). The HBP group included HBP/+DM and HBP/–DM based on the presence or absence of DM. The CT-based RSN grade was scored from 0 to 2 by two radiologists, respectively, where RSN grade 0 indicated smooth renal surface, grade 1 was mild RSN, and grade 2 was marked RSN. Results The inter-rater agreement on RSN was good (Kappa = 0.76). The age-specific rate of RSN grade 1–2 was bigger in the HBP group than in the control group (42.86% [40%–49.22%] vs. 2.18% [0.00%–22.5%]; P = 0.005). RSN grade was associated with HBP course ( P < 0.02). The rates of RSN grade 1–2 and of RSN grade 2 were bigger in the HBP/+DM group than those in the HBP/–DM group (48.84% vs. 37.84%, and 18.61% vs. 1.35%, respectively; all P = 0.001). Neither HBP course nor HBP grade correlated with rate of RSN grade ( P > 0.05). The eGFR was similar among the RSN grades in HBP or between the HBP and control groups ( P > 0.05). Conclusion RSN was associated with HBP compared to normotensive patients.
Prognostic association between NLRP3 inflammasome expression level and operable pancreatic adenocarcinoma
Authors: Zheng Lina , Liu Hailiang 
Published: June 2022

Background The NLRP3 inflammasome is significantly associated with tumor development and metastasis in various malignancies. However, the significance of the NLRP3 inflammasome in pancreatic adenocarcinoma has not been fully determined. Therefore, we try to evaluate the expression of the NLRP3 inflammasome in pancreatic adenocarcinoma and analyzed its prognostic significance. Methods This cohort study enrolled 98 patients with primary pancreatic adenocarcinoma who received curative surgery. The NLRP3 inflammasome expression levels in cancer tissue were determined by immunohistochemistry, and compared with that of adjacent normal tissues. The association between NLRP3 inflammasome expression levels and baseline clinicopathological characteristics were also analyzed. Moreover, the correlation between NLRP3 inflammasome expression levels and survival was analyzed by log-rank test, and the survival curve was made by the Kaplan–Meier survival analysis. Results Expression of each NLRP3 inflammasome component in cancer tissue was higher than that in the adjacent normal tissues (all P < 0.05), including NLRP3, IL-1β, ASC, and Caspase-1. All four components of the NLRP3 inflammasome were closely associated with clinical stage and lymph node status (all P < 0.05). The Kaplan–Meier log rank test showed that the high expression level of the NLRP3 inflammasome was significantly related to poor overall survival in pancreatic adenocarcinoma patients. Conclusions NLRP3 inflammasome expression was upregulated in cancer tissue and closely associated with the prognosis of operable pancreatic adenocarcinoma.
The Influence of Breastfeeding Promotion Programs on Exclusive Breastfeeding Rates in Sub-Saharan Africa: A Systematic Review and Meta-Analysis
Authors: Chipojola Roselyn , Khwepeya Madalitso , Gondwe Kaboni Whitney , Rias Yohanes Andy , Huda Mega Hasanul 
Published: June 2022

Background: The benefits of breastfeeding in promoting child survival are well recognized. As one of the nutritional interventions for children, exclusive breastfeeding protects babies from various diseases that contribute to infant morbidity and mortality. However, no systematic review and meta-analysis has examined the influence of breastfeeding promotion programs on exclusive breastfeeding rates in sub-Saharan Africa. Research Aim: We examined the influence of breastfeeding promotion programs on exclusive breastfeeding rates at < 1 month, and at 1–5 months of breastfeeding in sub-Saharan countries including Ghana, Burkina Faso, Uganda, South Africa, Guinea-Bissau, Kenya, Tanzania, and the Democratic Republic of Congo. Methods: A systematic review and meta-analyses study of randomized controlled trials and quasi-experimental studies was conducted by searching in electronic databases and articles’ reference lists. Two investigators independently evaluated and extracted the data. A total of 131 studies were identified using five databases. Of the 10 studies meeting the inclusion criteria for systematic review, seven studies were included in the meta-analysis. We used a random-effects model to pool studies together and performed a subgroup analysis. Results: Breastfeeding promotion programs resulted in significantly higher exclusive breastfeeding rates at < 1 month ( OR = 1.60, 95% CI [1.36,1.86]). However, there was no significant effect observed for exclusive breastfeeding at 1–5 months. Combined interventions were more effective in improving exclusive breastfeeding rates than individual counseling or home-based counseling alone. Conclusion: Breastfeeding promotion programs in sub-Saharan Africa are effective in increasing exclusive breastfeeding rates at 6 months after birth.
Bridge or Barrier? The Impact of Network Capital on the Receipt of Long-Term Care Services in Germany
Authors: Baum Ariane 
Published: June 2022

Objectives In Germany, roughly 8.3 million people are in need of care, but only one-third of them receive state care benefits. The study investigates whether the individual network of a care-seeking person, as well as its resources, interact with health status on the likelihood of accessing formal care services. Methods German data from the Survey of Health, Ageing and Retirement in Europe (SHARE) from 2015 were used in several Firth logistic regressions with interaction terms. Results Health limitations are a significant predictor for the probability of receiving formal care benefits. As moderating factors, caregivers from the immediate family as well as caregivers with lower levels of education tend to contribute to an increase in this probability. Discussion Findings are based on a limited data set and indicate the importance of further research in this area to examine the mechanisms of access to formal care more precisely.
Differential impact of disease activity and damage on health-related quality of life in patients with systemic lupus erythematosus
Authors: Riaz Muhammad M , Shen Liang , Lateef Aisha , Cho Jiacai 
Published: June 2022

Background To study the association between disease activity, disease-related organ damage and health-related quality of life (HRQoL) among Asian patients with systemic lupus erythematosus (SLE). Methods We prospectively recruited adult SLE patients from a single tertiary center and followed them three-monthly. We recorded the SLE Disease Activity Index 2000 (SLEDAI-2K) at each visit. SLICC-ACR damage index (SDI) and HRQoL (Medical Outcomes Survey Short Form 36 (SF-36)) were recorded annually. We evaluated the association between SLEDAI-2K and SDI with SF-36 physical (PCS) and mental (MCS) component scores using linear mixed effect models. Results We studied 198 patients, comprising Chinese, Malays and Indians. The mean (SD) age at enrollment was 47.1 (12.5) years. The baseline median (IQR) SLEDAI-2k was 2 (0–4). While the mean PCS improved significantly in the second and third year, MCS was unchanged. In the multivariable mixed model analysis, SDI, but not SLEDAI-2k, was significantly associated with poorer PCS (estimate of coefficient (SE) −0.81 (0.29), p < .01). Conversely, SLEDAI-2k, but not SDI, was negatively associated with MCS (estimate of coefficient (SE) −0.36 (0.17), p = .04). Conclusion In this cohort of multi-ethnic Asian SLE patients, disease activity is associated with poorer mental, but not physical, HRQoL; whereas disease-related damage is associated with poorer physical, but not mental HRQoL. Our findings suggest a need to differentially approach the impaired HRQoL in SLE patients at different phases of disease; possibly by treating disease activity in patients with impaired mental HRQoL and addressing disease-related damage in patients with impaired physical functioning.
Improved pregnancy outcomes in systemic lupus erythematosus: A retrospective study of pregnancies from a single centre in Denmark from 2010–2020 compared with the period 1990–2010
Authors: Gohr Mette , Jakobsen Iris Marie , Helmig Rikke Bek , Stengaard-Pedersen Kristian , Laurberg Trine Bay , Troldborg Anne 
Published: June 2022

Objectives Over the past decades new international guidelines recommend that pregnant Systemic lupus erythematosus (SLE) patients are monitored closely in a multi-professional team throughout pregnancy. The importance of low disease activity before pregnancy and continued treatment during pregnancy has been established. However, there is still a high risk of adverse pregnancy outcome (APO). The APO in a Danish SLE cohort was evaluated and compared with the results in a previous study cohort from the same centre and referral area. Methods This retrospective cohort study used the local patient registry to identify pregnancies in SLE patients followed at the Department of Rheumatology, Aarhus University Hospital, Denmark, from January 2010 to October 2020. In total, 66 pregnancies were registered in 41 women. Data were compared with a previous retrospective study (1990–2010) from the same hospital. Results Adverse pregnancy outcome occurred in 65% of pregnancies. Forty-seven pregnancies resulted in a live birth, while 15 ended in miscarriages. Compared to the 1990–2010 cohort, a numerical reduction in preterm deliveries (7.58% vs. 17.9%) and emergent caesarean (6.1% vs. 15.5%) was observed, although not reaching statistical significance ( p = .07 in both cases). Further, a higher average birth weight (3045 g vs. 2870 g) as well as a higher number of pregnancies and live births per year were observed. Gestational hypertension was significantly reduced from 23.8% to 13.6% ( p = .05). Significantly more patients were treated with prednisolone (66.7% vs 35.7%, p = .0002), hydroxychloroquine (6% vs. 73.4%, p < .0001) and acetylsalicylic acid (39.3% vs. 73.1%, p = .0001) in 2010–2020 compared to the 1990–2010. Conclusion We observed significant improvements in the frequency of some APOs in the recent 2010–2020 cohort compared with the previous cohort followed from 1990 to 2010. However, even though a specialized multi-professional team closely follows SLE patients through their pregnancies, pregnancy in SLE still carries a high risk of APO.
Comparison of Standard-Dose Versus High-Dose Dexmedetomidine in Extracorporeal Membrane Oxygenation
Authors: Zarfoss Erika L. , Garavaglia Jeffrey , Hayanga J. W. Awori , Kabulski Galen 
Published: June 2022

Background Dexmedetomidine is commonly used to achieve light sedation in patients on extracorporeal membrane oxygenation (ECMO) despite minimal evidence. In vivo studies have shown dexmedetomidine sequestration in ECMO circuits, and higher doses may be used to overcome sequestration. Objective The purpose of this study was to compare safety and efficacy of dexmedetomidine at standard versus high doses in ECMO Methods A retrospective analysis of adult ECMO patients was performed. Patients were compared as receiving either standard-dose (≤1.5 µg/kg/h) or high-dose (>1.5 µg/kg/h) dexmedetomidine. Safety outcomes included new onset bradycardia or hypotension. Efficacy was compared by the addition of concomitant sedative and analgesic agents. Results One hundred five patients were evaluated, with 20% of patients in the high-dose group. Comparing standard and high dosing, no significant differences were seen in primary safety outcomes including bradycardia (49% vs 38%, P = 0.46), hypotension (79% vs 71%, P = 0.56), or addition of vasopressors (75% vs 71%, P = 0.78). Need for concomitant analgesic agents and propofol was similar between groups. Conclusion and Relevance This represents the first evaluation of use of high-dose dexmedetomidine in ECMO. Rates of dexmedetomidine higher than 1.5 µg/kg/h were commonly used in patients on ECMO, with similar rates of adverse effects and need for concomitant propofol and analgesic agents. While high-dose dexmedetomidine may be as safe as standard dose, no additional efficacy was found.
The Impact of a Diabetes Transitions of Care Clinic on Hospital Utilization and Patient Care
Authors: Rinaldi Alyssa , Snider Melissa , James Amy , Harris Cara , Cephas Hill Kelly , Li Junan , Wyne Kathleen 
Published: June 2022

Background There is currently limited guidance from the American Diabetes Association regarding transitions of care for patients with diabetes. Objective This study’s aim was to determine the impact of a diabetes-specific transitions of care clinic (TOCC) on hospital utilization and patient outcomes in recently discharged patients with diabetes. Methods This retrospective study evaluated patients seen by TOCC as compared with similar patients discharged from the study institution the year prior. The primary outcome was a composite of the number of unique patients with readmissions/emergency department (ED) visits within 30 days of discharge. Secondary outcomes included a subcomponent analysis of readmissions/ED visits, index hospital length of stay (LOS), and to describe clinical interventions made in clinic. This study was approved by the institutional review board of the Office of Responsible Research Practice at the Ohio State University Wexner Medical Center. Results There were 165 patients in the TOCC group and 157 in the control group based on the matching criteria. There was a statistically significant decrease in the primary outcome in the TOCC group versus the control group (18% vs 36%, P < 0.001). In evaluation of its subcomponents, there was a statically significant decrease in patients with readmissions (11% vs 26%, P < 0.001) but not ED visits (10% vs 17%, P = 0.096). The LOS for the TOCC group was shorter at 4 days versus 5 days in the control group ( P = 0.055). Conclusions and Relevance The implementation of a diabetes-specific TOCC can decrease both readmissions and ED visits and may impact hospital LOS. In addition, a TOCC can be used to identify gaps in preventive care. The results from this study may help support the creation of similar TOCC at other institutions.
Effect of COVID-19 lockdown on refractive errors in Italian children aged 5–12 years: A multi-center retrospective study
Authors: Trovato Battagliola Edoardo , Mangiantini Pietro , D’Andrea Mattia , Malvasi Mariaelena , Loffredo Lorenzo , Scalinci Sergio Zaccaria , Comberiati Anna Maria , Migliorini Raffaele , Pacella Elena 
Published: June 2022

Purpose to explore the potential consequences of the COVID-19 lockdown on the prevalence of myopia among Italian children aged 5–12 years. Materials and Methods retrospective multicenter study conducted in Italy. Population: children aged 5–12. Selection: random selection of children who received an eye exam between 2016 to 2021. Inclusion criteria: healthy children presenting for a routine eye exam. Exclusion criteria: presence of ocular comorbidities other than refractive error, such as blepharoptosis, media opacities, corneal or retinal dystrophies, strabismus, amblyopia, or concurrent therapy with atropine 0.01%. Outcome measure: age and spherical equivalent (SE) measured in diopters (D) in the right eye (RE) in cycloplegia. Statistical analysis: ANOVA test. Results total of 803 children. In the years prior to COVID-19, the mean SE ± SD of healthy age-school children was: 0.54 ± 1.49 D in 2016; 0.43 ± 1.84 D in 2017; 0.34 ± 1.41 D in 2018; 0.35 ± 1.75 D in 2019 (ANOVA, p = .659). In 2021, the mean SE changed to −0.08 ± 1.44 D (ANOVA, p = .005). Mean age was comparable in all groups (ANOVA, p = .307). The prevalence of myopes (SE ≤−0.5D) and hyperopes (SE ≥ 2D) was respectively 24.10% and 9.64% among children aged 60–96 months, and 63.86% and 6.02% among children aged 97–144 months. These values represent a statistically-significant increase in the number of myopes (Chi-square, p = .016) and decrease in the number of hyperopes (Chi-square, p = .001), as compared to previous years (.06 and.48 respectively). Conclusion this retrospective study shows a statistically-significant decrease in the mean SE in children aged 5–12 in the year following the COVID-19 lockdown. The percentage of myopes has increased significantly, while the percentage of hyperopes has decreased. The lifestyle changes caused by the lockdown led children to spend more time on near-work activities and digital devices, and less time outdoors. These are known risk factors for the development and progression of myopia. Studies in different countries are encouraged.
Low probability of myasthenia Gravis in patients presenting to neuro-ophthalmology clinic for evaluation of isolated ptosis
Authors: Donaldson Laura , Issa Mariam , Dezard Victoria , Margolin Edward 
Published: June 2022

Background Concerning causes of ptosis, most notably third nerve palsy and Horner's syndrome, can be ruled out with normal ocular motility and pupillary examination. Myasthenia gravis (MG) however, rarely can present with ptosis as an isolated finding. We reviewed all patients presenting to tertiary neuro-ophthalmology practice with ptosis of unknown etiology to determine the frequency of MG. Methods Retrospective chart review of patients referred to a tertiary neuro-ophthalmology practice with undifferentiated ptosis. Results Sixty patients were included in the study. Twenty eight (47%) patients had ptosis along with various abnormalities of ocular motility and/or alignment and 32 (53%) had isolated unilateral ptosis defined as ptosis with absence of diplopia, or symptoms of generalized MG (GMG). Final diagnosis was aponeurotic ptosis due to levator palpebrae dehiscence in the majority (73%) of patients, while 10 (17%) were diagnosed with MG (6 with OMG, 4 with GMG). Diplopia was present in 9/10 patients with MG and 8/10 had abnormal ocular findings on clinical examination such as orbicularis oculi weakness, Cogan's lid twitch or fatiguability of ptosis on sustained upgaze. Only one patient referred for isolated unilateral ptosis was diagnosed with OMG and this patient had orbicularis oculi weakness. Conclusions None of the patients with isolated unilateral ptosis and otherwise normal examination had MG. All patients eventually diagnosed with MG had diplopia or orbicularis weakness on examination. Thus, the yield of investigating patients with isolated ptosis for MG is exceedingly low.
A national co-design workshop of a mobile-based application for vascular access as a patient decision aid
Authors: Kingsmore David , Meiklem Ramsay , Stevenson Karen , Thomson Peter , Bouamrane Matt , Dunlop Mark 
Published: June 2022

Background: Increasing options for vascular access have increased the need for more effective communication to optimize patient engagement and ensure effective consent. An advanced prototype of the mobile application (VA App) was developed over 3 years as a patient decision aid. For the first time, entry to the 2021 UK Kidney Week was opened to all professions and patients and was held online. The VA App was presented in an inter-active session. This report summarizes the findings. Methods: A 30-min interactive session was allocated with the session delivered in four sections: (1) demographic data was collected; (2) an overall opinion was obtained about current patient information sources and satisfaction with these; (3) the participants were asked a series of eight questions regarding the main problem areas previously identified; (4) following a 6-min demonstration video, the participants were then re-asked the same questions to determine if the VA App would improve/worsen these areas. Results: Completed data from 30 participants showed great variation in all demographics. The most cited source was verbal and rated the best, whilst all other sources were felt to be poor by 90%. All eight aspects of current information sources rated poorly. There was a unanimous agreement that the VA App could make this better. Interestingly, when the eight aspects were ranked by order of the worst to best, this matched the order of the benefits of the VA App. Discussion: This is the first report of an on-line, multi-professional co-design workshop. With a unanimous view that current systems are very limited and that better patient information systems are required, the VA App was found to be a potential solution as a patient decision aid. Interestingly, paper leaflets were widely viewed as the least used and the least effective mechanism for communicating information to patients. Funding for a commercially produced mobile application has been secured and will be further tested in the near future.