bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward Safer Opioid Prescribing in HIV care (TOWER): a mixed-methods, cluster-randomized trial
Authors: Cedillo Gabriela , George Mary Catherine , Deshpande Richa , Benn Emma K. T. , Navis Allison , Nmashie Alexandra , Siddiqui Alina , Mueller Bridget R. , Chikamoto Yosuke , Weiss Linda , Scherer Maya , Kamler Alexandra , Aberg Judith A. , Vickrey Barbara G. , Bryan Angela , Horn Brady , Starkweather Angela , Fisher Jeffrey , Robinson-Papp Jessica 
Published: May 2022

AbstractBackgroundThe 2016 U.S. Centers for Disease Control Opioid Prescribing Guideline (CDC Guideline) is currently being revised amid concern that it may be harmful to people with chronic pain on long-term opioid therapy (CP-LTOT). However, a methodology to faithfully implement the CDC guideline, measure prescriber adherence, and systematically test its effect on patient and public health outcomes is lacking. We developed and tested a CDC Guideline implementation strategy (termed TOWER), focusing on an outpatient HIV-focused primary care setting.MethodsTOWER was developed in a stakeholder-engaged, multi-step iterative process within an Information, Motivation and Behavioral Skills (IMB) framework of behavior change. TOWER consists of: 1) a patient-facing opioid management app (OM-App); 2) a progress note template (OM-Note) to guide the office visit; and 3) a primary care provider (PCP) training. TOWER was evaluated in a 9-month, randomized-controlled trial of HIV-PCPs (N = 11) and their patients with HIV and CP-LTOT (N = 40). The primary outcome was CDC Guideline adherence based on electronic health record (EHR) documentation and measured by the validated Safer Opioid Prescribing Evaluation Tool (SOPET). Qualitative data including one-on-one PCP interviews were collected. We also piloted patient-reported outcome measures (PROMs) reflective of domains identified as important by stakeholders (pain intensity and function; mood; substance use; medication use and adherence; relationship with provider; stigma and discrimination).ResultsPCPs randomized to TOWER were 48% more CDC Guideline adherent (p < 0.0001) with significant improvements in use of: non-pharmacologic treatments, functional treatment goals, opioid agreements, prescription drug monitoring programs (PDMPs), opioid benefit/harm assessment, and naloxone prescribing. Qualitative data demonstrated high levels of confidence in conducting these care processes among intervention providers, and that OM-Note supported these efforts while experience with OM-App was mixed. There were no intervention-associated safety concerns (defined as worsening of any of the PROMs).ConclusionsCDC-guideline adherence can be promoted and measured, and is not associated with worsening of outcomes for people with HIV receiving LTOT for CP. Future work would be needed to document scalability of these results and to determine whether CDC-guideline adherence results in a positive effect on public health.Trial registrationhttps://clinicaltrials.gov/ct2/show/NCT03669939. Registration date: 9/13/2018
Experimental Study on the Property and Mechanism of the Bonding Between Rubberized Concrete and Normal Concrete
Authors: Feng Ling-Yun , Chen Ai-Jiu , Liu Han-Dong 
Published: May 2022

AbstractScholars have studied the impact of rubber particles (RPs) on the performance of the concrete and the research topics have covered all the mechanical properties and durability of normal concrete (NC). Recently, scholars have turned their research interest to the structural properties of concrete. However, there are few experimental studies on the bonding properties of RC to NC. The RPs have both positive and negative impacts on the bond performance. On one hand, RPs can reduce the shrinkage of concrete, resulting in reduced shear stress and tensile stress near the bonding boundary. On the other hand, RPs cause a reduction in the overall strength of concrete, resulting in the poor mechanical performance of the interface transition layer between the two concrete. The test results of this study show that the bonding splitting tensile strength between freshly mixed RC to aged NC first increases and then decreases with the rise of the RPs content in the RC, and the bonding splitting tensile strength reaches the peak when the RPs content is 10%. The bonding splitting tensile strength between the NC and the RC mixed with 3–5 mm RP is higher than that between the NC and the RC mixed with 1–3 mm RPs. When mixed with modified RPs, the bonding splitting tensile strength between the RC and the NC is improved. Applying an interfacial agent (a cement slurry or an epoxy) on the old concrete bonding surface can significantly improve the bonding splitting tensile strength. The results of non-repeated two-way ANOVA show that the content of the RPs and the type of the interfacial agent have significant effects on the bond splitting tensile strength, while the size and modification of the RPs have no significant effects on the bond splitting tensile strength.
Myelodysplastic syndromes are multiclonal diseases derived from hematopoietic stem and progenitor cells
Authors: Luo Bingqing , Dong Fang , Qin Tiejun , Zhang Qingyun , Bai Haitao , Wang Jinhong , Jia Yujiao , Ma Shihui , Jiang Erlie , Cheng Tao , Xiao Zhijian , Ema Hideo 
Published: May 2022

AbstractMyelodysplastic syndromes (MDS) are generally considered as a group of clonal diseases derived from hematopoietic stem cells, but a number of studies have suggested that they are derived from myeloid progenitor cells. We aimed to identify the cell of origin in MDS by single-cell analyses. Targeted single-cell RNA sequencing, covering six frequently mutated genes (U2AF1, SF3B1, TET2, ASXL1, TP53, and DNMT3A) in MDS, was developed and performed on individual cells isolated from the CD34+ and six lineage populations in the bone marrow of healthy donors (HDs) and patients with MDS. The detected mutations were used as clonal markers to define clones. By dissecting the distribution of clones in six lineages, the clonal origin was determined. We identified three mutations both in HDs and patients with MDS, termed clonal hematopoiesis (CH) mutations. We also identified fifteen mutations only detected in patients with MDS, termed MDS mutations. Clonal analysis showed that CH clones marked by CH mutations and MDS clones marked by MDS mutations were derived from hematopoietic stem cells as well as various hematopoietic progenitor cells. Most patients with MDS showed the chimeric state with CH clones and MDS clones. Clone size analysis suggested that CH mutations may not contribute to clonal expansion of MDS. In conclusion, MDS comprise multiple clones derived from hematopoietic stem and progenitor cells.
Could China’s journey of malaria elimination extend to Africa?
Authors: Wang Duoquan , Lv Shan , Ding Wei , Lu Shenning , Zhang Hongwei , Kassegne Kokouvi , Xia Shang , Duan Lei , Ma Xuejiao , Huang Lulu , Gosling Roly , Levens Joshua , Abdulla Salim , Mudenda Mutinta , Okpeku Moses , Matengu Kenneth Kamwi , Serge Diagbouga Potiandi , Xiao Ning , Zhou Xiao-Nong 
Published: May 2022

AbstractWorld Health Organization (WHO) certified China malaria-free on June 30, 2021, which brightens the goal of global malaria elimination efforts. China contributed its unique innovations to the global community: Artemisinin, discovered by Tu Youyou, has saved millions of lives globally; the “1-3-7” norm developed in 2012, has been adapted in the local contexts of countries in the Southeast Asia and Africa. How to the targets of Global Technical Strategy for Malaria (GTS) 2016−2030. By looking into the malaria control phase, towards elimination phase from 1960 to 2011 in sub-Saharan Africa and China, we found that the gap in malaria burden will widen unless the interventions in Africa are enhanced. It is imperative to identify the key China–Africa cooperation areas on malaria control and elimination, so that synergized efforts could be pooled together to help African countries achieve the elimination goal. The practices from China malaria control and elimination efforts could be leveraged to fast-track malaria elimination efforts in Africa, which makes it possible that the China’s journey of malaria elimination extends to Africa.
Graphical Abstract
Machine learned daily life history classification using low frequency tracking data and automated modelling pipelines: application to North American waterfowl
Authors: Overton Cory , Casazza Michael , Bretz Joseph , McDuie Fiona , Matchett Elliott , Mackell Desmond , Lorenz Austen , Mott Andrea , Herzog Mark , Ackerman Josh 
Published: May 2022

Abstract
Background
Identifying animal behaviors, life history states, and movement patterns is a prerequisite for many animal behavior analyses and effective management of wildlife and habitats. Most approaches classify short-term movement patterns with high frequency location or accelerometry data. However, patterns reflecting life history across longer time scales can have greater relevance to species biology or management needs, especially when available in near real-time. Given limitations in collecting and using such data to accurately classify complex behaviors in the long-term, we used hourly GPS data from 5 waterfowl species to produce daily activity classifications with machine-learned models using “automated modelling pipelines”.

Methods
Automated pipelines are computer-generated code that complete many tasks including feature engineering, multi-framework model development, training, validation, and hyperparameter tuning to produce daily classifications from eight activity patterns reflecting waterfowl life history or movement states. We developed several input features for modeling grouped into three broad categories, hereafter “feature sets”: GPS locations, habitat information, and movement history. Each feature set used different data sources or data collected across different time intervals to develop the “features” (independent variables) used in models.

Results
Automated modelling pipelines rapidly developed easily reproducible data preprocessing and analysis steps, identification and optimization of the best performing model and provided outputs for interpreting feature importance. Unequal expression of life history states caused unbalanced classes, so we evaluated feature set importance using a weighted F1-score to balance model recall and precision among individual classes. Although the best model using the least restrictive feature set (only 24 hourly relocations in a day) produced effective classifications (weighted F1 = 0.887), models using all feature sets performed substantially better (weighted F1 = 0.95), particularly for rarer but demographically more impactful life history states (i.e., nesting).

Conclusions
Automated pipelines generated models producing highly accurate classifications of complex daily activity patterns using relatively low frequency GPS and incorporating more classes than previous GPS studies. Near real-time classification is possible which is ideal for time-sensitive needs such as identifying reproduction. Including habitat and longer sequences of spatial information produced more accurate classifications but incurred slight delays in processing.
Complete remission of an early-stage laryngeal cancer under combined pembrolizumab and chemotherapy treatment of a synchronous lung adenocarcinoma
Authors: Linxweiler Maximilian , Kühn Jan Philipp , Neubert Christian , Khreish Fadi , Balensiefer Benedikt , Wagner Mathias , Schick Bernhard 
Published: May 2022

Background Anti-PD1-Checkpoint inhibition (CI) is an established treatment of recurrent and/or metastatic head and neck cancer. A potential benefit from CI in early-stage disease that is usually treated by radiation or surgery has not been investigated so far and is currently not addressed in clinical trials. Case presentation A 58-year-old man was diagnosed with a cT2 supraglottic laryngeal cancer and a synchronous metastasized adenocarcinoma of the lung. As the patient refused any treatment of his laryngeal cancer, he received combined immune-chemotherapy according to the KEYNOTE-189 protocol. After 4 cycles of pembrolizumab/carboplatin/pemetrexed, the patient showed a complete remission of his laryngeal cancer with a clear shrinkage of the mediastinal and hilar lung cancer metastases. After 21 cycles of maintenance therapy, the lung adenocarcinoma shows a stable disease status with no signs of any residual or recurrent laryngeal cancer. Conclusions Anti-PD1-CI may be a treatment option also for early-stage HNSCC with excellent functional outcome when established therapies are not available. Graphical abstract
Geoenvironmental investigation of Sahure’s pyramid, Abusir archeological site, Giza, Egypt
Authors: Fahmy Abdelrhman , Molina-Piernas Eduardo , Domínguez-Bella Salvador , Martínez-López Javier , Helmi Fatma 
Published: May 2022

Abstract
Abusir is the name of an elaborate burial area in Egypt, dotted with 19 pyramids and other temples, stretching on the western side of the Nile from the south of the Giza Plateau to the northern rim of Saqqara. It seems to have been created as the resting site for the Pharaohs dated from 2494 to 2345 BC. The name Abusir, originally spoken as Busiri, means “Temple of Osiris”. Over time, the name has become so popular because more than 60 villages now carry this name, but only one is the archaeological site. This paper focused on one of its most important pyramids from the Abusir archaeological area, Sahure's pyramid, since it is one of Egypt’s little-known but heavily damaged treasures. Field and laboratory studies have been carried out to investigate and understand the durability problems and construction materials of this pyramid, leading to results that confirmed the impact of the geoenvironmental conditions on the pyramid's architectural, structural, and engineering stability. Moreover, the results showed that mineralogical content in the construction materials was an intrinsic problem due to the presence of swellable (expansive) clays, which are considered responsible for pyramid decay and damage. In addition to external factors such as the effect of temperature variations, rain, pollutants, wind, and earthquakes and their interactions with intrinsic building material defects. Finally, this paper revealed a new discovery for basaltic mortar as the first trial for green concrete manufacturing in the Egyptian Old Kingdom, Fifth Dynasty.
Golden bifid might improve diarrhea-predominant irritable bowel syndrome via microbiota modulation
Authors: Luo Mei , Liu Qin , Xiao Lin , Xiong Li-Shou 
Published: May 2022

Abstract
Objective
Gut microbiota might play a crucial role in the pathogenesis of irritable bowel syndrome (IBS), and probiotics supplement may be an effective treatment option. This study aims to explore the therapeutic effects of Golden bifid on the diarrhea-predominant IBS (IBS-D).

Methods
Twenty-one consecutive IBS-D patients were recruited based on Rome IV criteria. All patients took 2000 mg Golden bifid triple daily for 4 weeks. Gastrointestinal (GI) symptoms, psychological symptoms, small intestine bacterial overgrowth (SIBO) and fecal microbiota characteristics were evaluated in IBS-D patients before and after treatment.

Results
After 4-week treatment of Golden bifid, the GI symptoms such as abdominal pain (2.90 ± 1.04 vs. 1.90 ± 1.26, P = 0.002), abdominal distension (2.00 ± 1.34 vs. 1.29 ± 1.31, P = 0.007), diarrhea (3.24 ± 1.37 vs. 1.81 ± 1.21, P = 0.001), defecatory urgency (3.48 ± 1.03 vs. 2.33 ± 1.35, P = 0.000) and incomplete evacuation (2.71 ± 1.15 vs. 1.76 ± 1.26, P = 0.003) were significantly alleviated in IBS-D patients. The Self-Rating Depression Scale (SDS) decreased significantly (46.19 ± 11.36 vs. 43.33 ± 9.65, P = 0.041), and SIBO could be eradicated in 25% (4/16) of IBS-D patients with SIBO. Meanwhile, the abundance of Unclassified Lachnospiraceae and Dorea in genus level and Unclassified Lachnospiraceae, Bacterium Dorea, Bacterium Butyricicoccus and Dorea formicigenerans ATCC 27755 in species level were increased in fecal microbiota (P < 0.05).

Conclusions
Golden bifid could improve most of GI symptoms and depressive symptoms in IBS-D patients and eradicate a small proportion of SIBO in those IBS-D patients with SIBO. What's more, Golden bifid could also modulate the fecal microbiota in IBS-D patients, which implied that the Golden bifid might improve IBS-D via microbiota modulation.
Protective effects of methanolic extract of Andrographis paniculata (Burm.f.) Nees leaves against arsenic-induced damage in rats
Authors: Owoade Abiodun Olusoji , Alausa Abdullahi Opeyemi , Adetutu Adewale , Owoade Akinade William 
Published: May 2022

Abstract
Background
Medicinal plants are natural sources of antioxidants effective in the treatment of oxidative stress-mediated diseases. This study aims to evaluate the hepato-renal protective efficacy of Andrographis paniculata leaves methanolic extract in arsenic-induced oxidative stress. Animals were divided into four groups of six animals per group. The rats in groups 1 and 2 received normal saline, while rats in groups 3 and 4 received 200 mg/kg body weight of A. paniculata or ascorbic acid per day, respectively, for 7 days orally. The rats in groups 2, 3, and 4 received a single dose of arsenic at 10 mg/kg body weight intraperitoneally on day 7, and 24 h later, rats in all the groups were killed and the blood, liver, and kidney samples were collected for biochemical/histological studies.

Results
Administration of arsenic to rats induced a significant increase in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), cholesterol, urea, creatinine, and triglycerides in the plasma, while it decreased superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT) activities in the liver and kidney. It also significantly reduced the levels of white blood cells (WBC), red blood cells (RBC), platelet (PLT), and lymphocytes (LYM) in the blood. However, the levels of AST, ALT, cholesterol, urea, creatinine, and triglycerides in the plasma of groups of rats that received A. paniculata extract before administration of arsenic were decreased, while their SOD, GSH, and CAT levels were elevated in the liver and kidney. The values of their WBC, RBC, PLT, and LYM were also significantly increased when compared to the arsenic group rats. Histological observations showed varying degrees of liver damage in the arsenic group rats, while the histoarchitecture of the liver of rats that received A. paniculata extract were significantly improved.

Conclusions
This study demonstrated that A. paniculata extract ameliorates arsenic-induced hepato-renal toxicity and could be exploited in the management of toxicity effects associated with the arsenic.
Using common-reflection-surface stack for enhanced near-surface seismic reflection imaging: Examples from consolidated and unconsolidated environments
Authors: Bakhtiari Rad Parsa , Hickey Craig J. 
Published: May 2022

The small geophone spacing and spread lengths commonly used to investigate ultrashallow layers in conjunction with the limited bandwidth of surface impact sources do not allow for clear separation of different seismic arrivals. The interference of events and the high noise levels due to near-source offsets make shallow seismic data processing a challenging task. The wavefront attributes of seismic waves commonly used in conventional seismic processing are suggested to improve near-surface seismic reflection imaging. These wavefront attributes are often used as the stacking parameters in multidimensional time imaging methods such as common-reflection surface (CRS). It is shown in this paper that the CRS method can improve near-surface seismic data processing by enhancing: (1) unstacked gathers via a CRS-based local stacking scheme, (2) semblance picking for velocity model building, and (3) zero-offset stacked data via the CRS global stacking. The CRS-based local stacking can mitigate the loss of data associated with optimum-windowing-based muting of coherent noise. The CRS local stacking infills the muted zones via its robust data interpolation and regularization features and enhances the image quality. Furthermore, the CRS-based enhanced data allow for improved near-surface velocity model building by producing higher coherence and more focused semblance peaks. The CRS global stacking is shown to further smooth and provide more continuity of events in the zero-offset data. Applications to a synthetic and two field data sets collected from high- and low-velocity environments indicate the efficiency and feasibility of the proposed approach.
Role of Weekday Variation on Glucose, Insulin, and Triglyceride: A Cross-Sectional Analysis From the Maastricht Study
Authors: Clemmensen Kim K B , Koster Annemarie , Nielen Yannick T H , Dagnelie Pieter C , Stehouwer Coen D A , Bosma Hans , Wesselius Anke , Færch Kristine , Eussen Simone J P M 
Published: May 2022

Abstract

Context
The timing of sleep, physical activity, and dietary intake show variation over the week, with different timings in the weekend compared to the weekdays, which may potentially lead to impaired glucose and lipid regulation on Mondays compared to other weekdays.

Objective
The aim of the study was to investigate differences in glucose metabolism and fasting triglyceride concentrations on Mondays compared to the rest of the week.

Design, setting and participants
This cross-sectional study is based on data from the Maastricht Study, including 6067 participants without known diabetes and 1568 previously diagnosed with type 2 diabetes.

Main outcome measures
Confounder-adjusted linear regression analysis was applied to study the associations of day of the week of examination with glucose and insulin responses to an oral glucose tolerance test and fasting triglyceride concentrations.

Results
In fully confounder-adjusted models, mean (95% CI) concentrations of fasting glucose, insulin, and triglycerides were slightly higher on Mondays compared with the other weekdays [glucose: 1% (0-2); insulin: 9% (1-18); triglycerides: 5% (2-8)]. Interaction analyses revealed that the association of weekday with insulin was only pronounced in men [18% (3-35)], but not in women [1% (−8-10)], whereas the associations with glucose and triglycerides were only apparent for individuals with known type 2 diabetes [glucose: 4% (0-7); triglycerides: 14% (6-23)] compared to the background population [glucose: 0% (0-1); triglycerides: 3% (0-6)].

Discussion
Being examined on a Monday was associated with higher fasting insulin concentrations among men but not women.
German Ordoliberalism and Value Freedom: The Case of Walter Eucken
Authors: Nientiedt Daniel 
Published: May 2022

AbstractWalter Eucken (1891–1950), the founder of German ordoliberalism, is best known for his work on economic policy. According to the orthodox view, giving policy advice involves not only technical expertise but also judgments of value. Against this background, the present article investigates Eucken's stance on the principle of value freedom, that is, the claim that positive and normative statements should be kept separate. While Eucken defended the notion of scientific objectivity in his earlier writings, he later distanced himself from the principle of value freedom as formulated by Max Weber. This article maintains that a closer reading of Eucken and Weber reveals the similarity of their positions. Thus, Eucken should be seen as a proponent of the principle of value freedom. At the same time, his treatment of the subject suggests that his (implicit) model of policymaking is incomplete because it does not specify the ultimate source of value.