bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of double primary carcinoma was accidentally found during operation: hepatocellular carcinoma and appendiceal mucinous adenocarcinomas
Authors: Li Hai-Liang , Zhou Yi , Gao Peng , Zeng Xian-Cheng , Zhang Guo-Wei , He Bo-Hao 
Published: March 2022

Abstract
Background: Synchronous double primary cancer consisting of hepatocellular carcinoma (HCC) and appendiceal mucinous adenocarcinomas has not been reported in the world so far. Liver metastasis of digestive tract tumor is so common that it is easy to ignore the existence of double primary cancer in the digestive system. Appendiceal malignant tumor itself is easy to be misdiagnosed or missed. For the better understanding of HCC and appendiceal mucinous adenocarcinomas, the information of our recent case has been summarized.Case presentation: A 58-year-old man was admitted with repeated upper abdominal pain for one week. Imaging examination and liver biopsy pathology were diagnosed as hepatocellular carcinoma. Colonoscopy showed no obvious organic lesions in the terminal ileum and the whole large intestine. We had anatomical resection of S5, S6 segment of liver. At the same time, two suspicious lesions in the right liver were ablated by microwave. But at the end of the operation, we accidentally found a hard mass about 3cm x 3cm in size at the end of the appendix. And the rapid pathological results showed appendiceal adenocarcinoma, so we had a right hemicolectomy. So far, the diagnosis of the patient was changed to synchronous double primary cancer consisting of HCC and appendiceal mucinous adenocarcinomas.Conclusions: It is the first time we report a case of synchronous double primary hepatic cancer consisting of HCC and appendiceal mucinous adenocarcinomas in the world. Due to the rarity and unspecific clinical features, it is extremely challenging to be diagnosed preoperatively. It requires us to have a more comprehensive understanding of the patient's medical history, careful physical examination and comprehensive exploration of the abdominal cavity during the operation, so as to avoid missed diagnosis. Patients with HCC and appendiceal mucinous adenocarcinomas are generally associated with poor prognosis. It needs we put forward new countermeasures for the new question.
Using Next-generation Sequencing as Auxiliary Tool to gastric cancer with multiple intrahepatic neoplasms Diagnosis:primary cholangiocarcinomas or liver metastasis
Authors: xu fangye , xiao chunmei , shen kai , wang rong , he yuange , Xu Jiali , Liu Lianke 
Published: March 2022

Abstract
Since the pathogenesis of gastric cancer (GC) is generally disguised, with no unique clinical symptoms and manifestations, most patients have evolved to the advanced stage at the time of diagnosis when liver metastases are more likely to develop. Clinical diagnosis of liver metastasis in GC mainly depends on physical imaging methods, such as B-scan ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI), etc. Histopathologic diagnosis is the gold standard for differentiating both primary cancer and metastasis. Next-Generation Sequencing (NGS), a relatively new technique, is increasingly being employed in clinical settings to guide diagnosis and treatment. Here, we report a patient with gastric cardiac adenocarcinoma who developed multiple intrahepatic neoplasms more than one year after total gastrectomy. Enhanced chest CT showed there may be metastatic lesions, but primary liver carcinomas should be excluded, while percutaneous core needle biopsy of the liver suggested that it was invasive or metastatic carcinoma and immunohistochemistry (IHC) was recommended for further diagnosis. Then further IHC examination suggested that it was consistent with cholangiocarcinoma. We treated the patient as having double primary carcinoma of GC and cholangiocarcinoma. However, based on the consistency of genetic testing in gastric and liver tissues for somatic mutations and certain copy number variants (CNVs), as well as the imaging examination, with the assistance of multidisciplinary team (MDT), finally we concluded that the patient should be diagnosed with a GC with liver metastasis, which suggested that NGS, a promising and auxiliary diagnostic tool, can be beneficial when the histopathology is ambiguous.
Adherence to Pre-Operative Fasting Guidelines and Associated Factors Among Pediatric Surgical Patients in Selected Public Referral Hospitals, Addis Ababa, Ethiopia: Cross Sectional multicenter Study
Authors: Yimer Aragaw Hamza , Haddis Lidya , Abrar Meron , Seid Ahmed Muhye 
Published: March 2022

Abstract
Background
Fasting of children before anesthesia is mandatory with the aim of to reduce the complications of due to regurgitation, vomiting, aspiration during anesthesia and surgery. Prolonged fasting times have several negative implications in children due to high fluid turnover quickly leads to dehydration, hypotension, metabolic disturbances and hypoglycemia which lead to poor anesthetic outcomes.
Aims
The aim of this study was to assess adherence to preoperative fasting guidelines and associated factors among pediatrics patients undergoing elective surgery in Addis Ababa selected Public Hospitals, Ethiopia, 2020.
Methods
A cross-sectional survey was conducted in Addis Ababa selected Public hospitals, Ethiopia, 2020. A total sample of 279 pediatric patients with age up to 17 years scheduled for elective surgery included in the data collection. The data analysis was done with SPSS V.21 and the value of the variables and its associated factors was checked its association with logistic regression. Significance was determined at P -value < 0.05. The result was presented by using text, tables, charts, and graphs.
Results
A total of 279 pediatric patients were responded in the analysis, with a 98.6% response rate. Majority of the participants 251(89.96%) were not followed the guidelines of preoperative fasting. The mean fasting time for clear liquids was 10 ± 4.03 (2–18 hrs.), for breast milk 7.18 ± 2.26 (3.5–12 hrs.), and for solid foods 13.5 ± 2.76 (8–19 hrs.). The reasons for which the preoperative fasting delayed was due to incorrect order 35.1%, prior cases procedures took longer times 34.1%, and changing sequence of schedule was 20.8%.
Conclusion
The majority of children were still having prolonged fasting practice. The staff’s instructions and sequences of schedules are challenged to follow the international fasting guidelines protocol.
Mining of the biosynthetic potential of archaea reveals diverse anti-archaeal lanthipeptides
Authors: Liang Haoyu , Song Zhiman , Zhong Zheng , Zhang Dengwei , Yang Wei , Zhou Le , Older Ethan , Li Jie , Wang Huan , Zeng Zhirui , LI Yongxin 
Published: March 2022

Abstract
Microbes produce diverse secondary metabolites (SMs) such as signaling molecules and antimicrobials that meditate microbe-microbe interaction. Archaea, the third domain of life, are a large and diverse group of microbes that not only exist in extreme environments but are abundantly distributed throughout nature. However, our understanding of archaeal secondary metabolites lags far behind our knowledge of those in bacteria and eukarya. In particular, the metabolic origin of antagonistic interactions which shape the archaeal community remains elusive. Here, we analyze 7,157 de-replicated archaeal genomes to investigate the biosynthetic potential of archaeal SMs systematically, revealing 5,496 biosynthetic gene clusters (BGCs). Up to 2,079 BGCs encoding highly diverse ribosomally synthesized and post-translationally modified peptides (RiPPs) are widely distributed across the Archaea domain. Guided by genome mining, we discover three new lanthipeptides with diverse ring topologies from a halophilic archaeon of class Haloarchaea. Of these there lanthipeptides, a representative exhibited anti-archaeal activities against closely-related halophilic archaea, potentially mediating the archaeal antagonistic interactions. These discoveries of the widespread archaeal ribosomal peptide SMs are expected to stimulate the experimental study of poorly characterized archaeal chemical biology and highlight the potential of archaea as a new source of bioactive SMs.
Case-Case and Case-Control Genome-Wide Association Study, Polygenic Risk Score and Classical HLA Alleles Analysis of Cervical Human Papillomavirus (HPV)
Authors: Adebamowo Sally N. , Adeyemo Adebowale , Adebayo Amos , Achara Peter , Alabi Bunmi , Bakare Rasheed A. , Famooto Ayotunde O. , Obende Kayode , Offiong Richard , Olaniyan Olayinka , Ologun Sanni , Rotimi Charles ,   ACCME Research Group as part of the H3Africa Consortium, Adebamowo Clement A. 
Published: March 2022

Abstract

Genetic variants that underlie susceptibility to high-risk cervical human papilloma virus (hrHPV) infections are largely unknown. We conducted discovery case-case and case-control genome-wide association studies, replication, and meta-analysis, generated polygenic risk scores and examined the association of classical HLA alleles and cervical human papillomavirus (HPV) infections in a cohort of over 10,000 women. We identified genome-wide significant variants for prevalent hrHPV around LDB2 and for persistent hrHPV near TPTE2, SMAD2, and CDH12, which code for proteins that are significantly expressed in the human endocervix. Genetic variants associated with persistent hrHPV are in genes enriched for the antigen processing and presentation gene-set. HLA-DRB1*13:02, HLA-DQB1*05:02 and HLA-DRB1*03:01 were associated with increased risk and HLA-DRB1*15:03 with decreased risk of persistent hrHPV. The findings of this study expand our understanding of genetic risk factors for HPV persistence and highlight the role played by MHC class II molecules in clearing hrHPV after initial infection.
Urine specimen collection for diagnosing a urinary tract infection-patient experience and preference for urine specimen collection: A Qualitative Study
Authors: Collins Linda , Khasriya Rajvinder , Malone-Lee James 
Published: March 2022

Abstract
BackgroundA urinary tract infection (UTI) is very common and patients frequently present to their General Practitioner and emergency department with symptoms. Diagnosis of the infection is made by examining fresh urine with microscopy, to detect white cells and epithelial cells shed from the bladder or by submitting the urine for microbial culture. Patients are often requested to provide a urine specimen, but very little is known about the patient experiences of carrying out the task or their preference of specimen collection method. The aim of this study was to explore patient experiences and preferences between four different urine specimen collection methods for diagnosing the presence of a UTI.MaterialsSemi-structured interviews were conducted to explore patient experiences of four different urine specimen collection methods (midstream urine specimen (MSU), catheter specimen (CSU), Peezy MSU™ and Natural void). The interviews consisted of four open-ended questions and all data were collated and organised using NVivo to establish themes that emerged from the data.ResultsThe natural void without technique was repeatedly referred to and was regarded as being the most straightforward of all of the sampling methods. Pain symptoms were described only in the catheter method and not in the MSU, Peezy MSU™ or natural void method. The catheter was regarded as the urine collection method that produced the best specimen for diagnostic testing by the patients’.ConclusionA majority of the participants expressed the desire for straightforward urine sampling methods and preferred the natural void as a standard method in clinical practice.
Rapid naked-eye tracking of on-cell phenotype based on dual-aptamers-weaved cascade assembly of nanostructures
Authors: Li Genxi 
Published: March 2022

Abstract
Phenotypic plasticity is an emerging paradigm for providing biological and clinical insights into cancer initiation, progression, and resistance to therapy. However, it is a great challenge to tracking phenotypic information on live cells with high levels of sensitivity, specificity, and simplicity, when specific cancer cell subset is being targeted. In this work, we have successfully achieved cascade assembly of nanoparticles on the surface of specific cancer cells by design of a dual-aptamers-weaved molecularly AND logic system. Taking advantages of spatial addressability, precise controllability, and targeting recognition of the nanostructure assemblies, we can precisely label the target cell subset in large population of similar cells and rapidly obtain phenotypic information in response to the surface changes of captured cancer cells. Without sophisticated instruments, we can know the phenotypic information on HepG2 cells in whole blood with high level of sensitivity, and rapid naked-eye tracking of on-cell phenotype changes of HepG2 cells undergoing epithelial-mesenchymal transition (EMT).
Stages of crisis counseling interventions on abortus provocatus performers in pregnancy due to rape
Authors: Nahdhiyyah Husnun 
Published: March 2022

Purpose - The purpose of this study was to discuss the stages of counseling intervention for provocative abortion perpetrators in pregnancy due to rape. Method - The research method used in this article is library research. The research was conducted by collecting information and data with the help of various materials in the library such as books, previous research results, articles, notes and various journals related to the problem to be solved systematically to collect, process, and conclude data using the method.Result - A perpetrator of abortus provocatus in pregnancy due to rape is in dire need of crisis counseling in terms of physical, psychological, and mental trauma. The stages of crisis counseling intervention carried out by the counselor are: defining the problem, ensuring the counselee's safety, providing support, examining alternatives, making plans, and getting commitments.Implications – This research has an impact on knowing the stages of crisis counseling intervention carried out by counselors.Originality – This research used literature deeply about the stages of counseling intervention for abortus provocatus perpetrators in pregnancy due to rape.***Tujuan - Tujuan penelitian ini untuk membahas tahapan intervensi konseling bagi pelaku aborsi provokatif pada kehamilan akibat perkosaan.Metode - Metode penelitian yang digunakan dalam artikel ini adalah penelitian kepustakaan. Penelitian ini dilakukan dengan mengumpulkan informasi dan data dengan bantuan berbagai bahan yang ada di perpustakaan seperti buku, hasil penelitian sebelumnya, artikel, catatan dan berbagai jurnal yang berkaitan dengan masalah yang akan dipecahkan secara sistematis untuk mengumpulkan, mengolah, dan menyimpulkan data menggunakan metode.Hasil - Pelaku abortus provokatus dalam kehamilan karena perkosaan sangat membutuhkan konseling krisis dari segi trauma fisik, psikis, dan mental. Tahapan intervensi konseling krisis yang dilakukan oleh konselor adalah: mendefinisikan masalah, memastikan keselamatan konseli, memberikan dukungan, memeriksa alternatif, membuat rencana, dan mendapatkan komitmen.Implikasi - Penelitian ini berdampak pada mengetahui tahapan intervensi konseling krisis yang dilakukan oleh konselor.Originalitas - Penelitian ini menggunakan literatur secara mendalam tentang tahapan intervensi konseling bagi pelaku aborsi provokatif pada kehamilan akibat perkosaan.
Counseling guidance in improving family stability in facing a covid-19 pandemic
Authors: Umam Rois Nafi'ul 
Published: March 2022

Purpose – The purpose of this study is to provide a clear description of the issue of family stability during the pandemic and family counseling guidance as to the solution in improving family stability.Method – This study applied a descriptive qualitative approach with an interview as the technique to collect the data. The informants in this study were 5 people consisting of the executive board and the members of Al-Usroh family community in Balikpapan.Result - The result of the study shows that during the pandemic the issues influencing family stability are family financial crisis, boredom, and over anxiety. To improve family stability during the pandemic, family counseling guidance with a conjoint approach was carried out.Implication – This research might become a study on the application of family counseling guidance services to improve family stability.Originality – This study was about the effect of the covid-19 pandemic towards family stability and the role of family counseling guidance to improve family stability.***Purpose – Tujuan penelitian ini adalah untuk memberikan gambaran tentang masalah ketahanan keluarga di masa pandemi dan layanan bimbingan konseling keluarga sebagai solusi dalam meningkatkan ketahanan keluargaMethod – Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan teknik pengumpulan data wawancara. Informan dalam penelitian ini sebanyak 5 orang yakni dari pengurus dan anggota komunitas keluarga Al-Usroh BalikpapanResult - Hasil penelitian menunjukkan bahwa permasalahan di masa pandemi yang berpengaruh terhadap ketahanan keluarga seperti krisis finansial pada keluarga, kejenuhan dan kecemasan yang berlebihan. Dalam rangka meningkatkan ketahanan keluarga di masa pandemi ini, upaya yang dilakukan yakni melalui layanan bimbingan konseling kelompok dengan pendekatan conjoint.Implication – Penelitian ini dapat menjadi kajian tentang pemanfaatan layanan bimbingan konseling keluarga untuk meningkatkan ketahanan keluargaOriginality – Penelitian ini adalah penelitian tentang dampak pandemi covid-19 terhadap ketahanan keluarga dan peran bimbingan konseling keluarga untuk meningkatkan ketahanan keluarga
PEMBERDAYAAN EKONOMI MASYARAKAT BERBASIS MASJID Studi Kasus di Masjid Baiturrahman Klidon Sinduharjo Ngaglik Sleman
Authors: Muslim Azis 
Published: March 2022

In Indonesia todays, the number of mosques, according to the Indonesian Council of Mosques, is no less than 700 thousand mosques. This number represents the greatest number of mosques in the world. From the large number of those, only a small portion has still been developed for handling poverty problems. Based on ths issue, it is necessary examine the Baiturrahman Mosque in Klidon Sinduharjo Ngaglik Sleman. This study will investigate and describe the success of economic empowerment achieved by the mosque, especially in tackling the poverty problems among the surrounding congregation of societies. The study shows that the managements of Baiturrahman mosque operate some stages in empowering the local economy. First, they build management phases, such as building the perception of stakeholders regarding the mosque function, managing the mosque in accordance with modern management, and building success dreams. Second, they apply the management principles, such as serving the congregations, making innovation and creativity for them, giving and enhancing the congregations rule in the mosque. Third, they choose the right strategy, such as starting to do the simplest and easiest thing, as well as considering the ongrgations’ interests. ****Di Indonesia, jumlah masjid menurut Dewan Masjid Indonesia tidak kurang dari 700 ribu masjid. Jumlah ini merupakan jumlah terbesar dari masjid di dunia. Dari jumlah tersebut, hanya sebagian kecil masih dikembangkan untuk menangani masalah kemiskinan. Berdasarkan masalah tersebut, perlu melihat Masjid Baiturrahman di Klidon Sinduharjo Ngaglik Sleman. Peneliti-an ini akan menyelidiki dan menggambarkan keberhasilan pemberdayaan ekonomi yang dicapai oleh masjid, terutama dalam menanggulangi masalah kemiskinan di antara jama’ah sekitar masyarakat. Studi ini menunjukkan bahwa manajemen masjid Baiturrahman mengoperasikan beberapa tahapan dalam memberdayakan ekonomi lokal. Pertama, membangun manajemen, seperti membangun persepsi stakeholders mengenai fungsi masjid, mengelola masjid sesuai dengan manajemen modern, dan mimpi membangun kesuksesan. Kedua, menerapkan prinsip-prinsip manajemen, seperti melayani jama’ah, membuat inovasi dan kreativitas bagi mereka, memberikan dan meningkatkan jama’ah di masjid. Ketiga, memilih strategi yang tepat, seperti mulai melakukan hal yang sederhana dan mudah, serta mempertimbangkan kepentingan organisasi.
PENGARUH KETAATAN BERIBADAH TERHADAP KESEHATAN MENTAL MAHASISWA UIN WALISONGO SEMARANG
Authors: Mahfud Dawam , Mahmudah Mahmudah , Wihartati Wening 
Published: March 2022

The purpose of this research is to measure the level of influence of obedience worship to scholar mental hygiene in Walisongo State Islamic University Semarang. The population in this research is all of scholar in Walisongo State Islamic University Semarang. The method to collecting data use questionare and mental hygiene scale and obedience worship scale. To analyze use infential parametris statistic with simple regression and t-test. This research shows that there are influence of obedience worship to mental hygiene scholar in Walisongo State Islamic University. The average of scholar mental hygene value is 78,2000 with deviation standart 6,14175, and average of obedience worship value is 94,3636 with deviation standart 6,58985 with influence coefficient F is 47,096 with significance value (pvalue) 0,000.***Penelitian ini bertujuan mengukur besarnya pengaruh ketaatan beribadah terhadap kesehatan mental mahasiswa IAIN Walisongo Semarang. Populasi dalam penelitian ini adalah seluruh mahasiswa IAIN Walisongo Semarang. Teknik pengambilan sampel dilakukan dengan teknik Stratified Sampling. Teknik pengumpulan data menggunakan angket dan skala kesehatan mental dan skala ketaatan beribadah. Teknik analisis data menggunakan teknik statistik inferensial parametris dengan teknik analisis regresi sederhana dan uji t. Hasil temuan dalam penelitian ini adalah: Ada pengaruh ketaatan beribadah terhadap kesehatan mental mahasiswa UIN Walisongo Semarang, semakin tinggi pengaruh ketaatan beribadah maka semakin tinggi kesehatan mental mahasiswa UIN Walisongo Semarang. Sebaliknya, semakin rendah pengaruh ketaatan beribadah maka semakin rendah pula kesehatan mental mahasiswa IAIN Walisongo Semarang. Rata-rata nilai kesehatan mental mahasiswa 78, 2000 dengan standar deviasi 6,14175, sedangkan rata-rata nilai ketaatan beribadahnya 94,3636 dengan standar deviasi 6,58985 dengan koefisien pengaruh F sebesar 47,096 dengan nilai signifikansi (Pvalue) 0,000.