bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perancangan Aplikasi Pengenalan Teknik Dasar Pencak Silat untuk Anak Menggunakan Teknologi Augmented Reality
Authors: Tresnawati Dewi , Supriatna Asep Deddy , Puadi Aldi Nur 
Published: May 2022

Metode pembelajaran pencak silat pada anak saat ini dirasakan kurang menarik dan tidak efektif, hal ini disebabkan karena media yang digunakan saat ini bersifat konvensional. Sejalan dengan perkembangan teknologi, augmented reality telah mampu meningkatkan interaksi sehingga memberikan hasil yang efektif pada metode pembelajaran. Penelitian ini bertujuan untuk membangun sebuah media pembelajaran pengenalan teknik dasar pencak silat dengan teknologi Augmented Reality untuk anak yang sebelumnya menggunakan media pembelajaran lain sebagai media penyampaian materi. Metodologi penelitian yang digunakan adalah Multimedia Development Life Cycle, metode ini digunakan untuk menghasilkan produk tertentu dengan tahapan yang ada didalamnya yaitu Concept, Design, Material Collecting, Assembly, Testing, dan Distribution. Hasil dari penelitian ini berupa terciptanya aplikasi pengenalan teknik dasar pencak silat dengan menggunakan Augmented Reality untuk anak. Berdasarkan hasil pengujian beta yang menggunakan skala Likert, 94.4% dengan 10 responden menyatakan bahwa aplikasi yang dikembangkan efektif sebagai media pengenalan teknik dasar pencak silat.
Relationship of Extrinsic Risk Factors to Lower Extremity Injury in Collegiate Ballet Dancers
Authors: Huang Pi-Yin , Lin Chia-Wei , Jankaew Amornthep , Lin Cheng-Feng 
Published: May 2022

Ballet dancers are thought to be at higher risk of lower extremity injury. This objective of this study was to describe the self-reported incidence, location, and factors associated with lower extremity injury in collegiate ballet dancers. Two hundred and forty-nine female ballet dancers responded to a questionnaire that addressed their injury event/location, dance behavior over the past 2 years, and overall dance history. Behaviors assessed included the following: types and number of shoes worn (pointé shoes/ballet slippers), wear time, training time (session frequency and duration), use of warm-up/cool-down, and use of a strengthening program and lower extremity accessory. Overall dance history included age of the onset of training, total years of experience, and number of dance styles. Backward multivariable logistic regression analysis was used to determine the extent to which variables measured were associated with injury. Ankle injury was the most prevalent injury. Years of wearing pointé shoes (adjusted odds ratio = 1.21,p= 0.01) and days/weeks in pointé shoes (adjusted odds ratio = 1.26,p= 0.04) were associated with an increased risk of injury; while additional strengthening (adjusted odds ratio = 0.39,p= 0.02) and use of lower extremity accessories during classes/rehearsals (adjusted odds ratio = 0.64,p= 0.01) were protective associations. These findings suggested that the use of pointé shoes, lower extremity accessories, and additional exercise should specifically be recorded during evaluation of injured ballet dancers; and must be considered potential factors to modify during rehabilitation.
Coastal Natural and Nature-Based Features: International Guidelines for Flood Risk Management
Authors: Bridges Todd S. , Smith Jane McKee , King Jeffrey K. , Simm Jonathan D. , Dillard Maria , deVries Jurre , Reed Denise , Piercy Candice D. , van Zanten Boris , Arkema Katie , Swannack Todd , de Looff Harry , Lodder Quirijn , Jeuken Claire , Ponte Nigel , Gailani Joseph Z. , Whitfield Paula , Murphy Enda , Lowe Ryan J. , McLeod Elizabeth , Altman Safra , Cairns Colette , Suedel Burton C. , Naylor Larissa A. 
Published: May 2022

Natural and nature-based features (NNBF) have been used for more than 100 years as coastal protection infrastructure (e.g., beach nourishment projects). The application of NNBF has grown steadily in recent years with the goal of realizing both coastal engineering and environment and social co-benefits through projects that have the potential to adapt to the changing climate. Technical advancements in support of NNBF are increasingly the subject of peer-reviewed literature, and guidance has been published by numerous organizations to inform technical practice for specific types of nature-based solutions. The International Guidelines on Natural and Nature-Based Features for Flood Risk Management was recently published to provide a comprehensive guide that draws directly on the growing body of knowledge and practitioner experience from around the world to inform the process of conceptualizing, planning, designing, engineering, and operating NNBF. These Guidelines focus on the role of nature-based solutions and natural infrastructure (beaches, dunes, wetlands and plant systems, islands, reefs) as a part of coastal and riverine flood risk management. In addition to describing each of the NNBF types, their use, design, implementation, and maintenance, the guidelines describe general principles for employing NNBF, stakeholder engagement, monitoring, costs and benefits, and adaptive management. An overall systems approach is taken to planning and implementation of NNBF. The guidelines were developed to support decision-makers, project managers, and practitioners in conceptualizing, planning, designing, engineering, implementing, and maintaining sustainable systems for nature-based flood risk management. This paper summarizes key concepts and highlights challenges and areas of future research.
Description of Staphylococcal Strains from Straw-Coloured Fruit Bat (Eidolon helvum) and Diamond Firetail (Stagonopleura guttata) and a Review of their Phylogenetic Relationships to Other Staphylococci
Authors: Monecke Stefan , Schaumburg Frieder , Shittu Adebayo O. , Schwarz Stefan , Mühldorfer Kristin , Brandt Christian , Braun Sascha D. , Collatz Maximilian , Diezel Celia , Gawlik Darius , Hanke Dennis , Hotzel Helmut , Müller Elke , Reinicke Martin , Feßler Andrea T. , Ehricht Ralf 
Published: May 2022

The phylogenetic tree of the Staphylococcus aureus complex consists of several distinct clades and the majority of human and veterinary S. aureus isolates form one large clade. In addition, two divergent clades have recently been described as separate species. One was named Staphylococcus argenteus, due to the lack of the “golden” pigment staphyloxanthin. The second one is S. schweitzeri, found in humans and animals from Central and West Africa. In late 2021, two additional species, S. roterodami and S. singaporensis, have been described from clinical samples from Southeast Asia. In the present study, isolates and their genome sequences from wild Straw-coloured fruit bats (Eidolon helvum) and a Diamond firetail (Stagonopleura guttata, an estrildid finch) kept in a German aviary are described. The isolates possessed staphyloxanthin genes and were closer related to S. argenteus and S. schweitzeri than to S. aureus. Phylogenetic analysis revealed that they were nearly identical to both, S. roterodami and S. singaporensis. We propose considering the study isolates, the recently described S. roterodami and S. singaporensis as well as some Chinese strains with MLST profiles stored in the PubMLST database as different clonal complexes within one new species. According to the principle of priority we propose it should be named S. roterodami. This species is more widespread than previously believed, being observed in West Africa, Southeast Asia and Southern China. It has a zoonotic connection to bats and has been shown to be capable of causing skin and soft tissue infections in humans. It is positive for staphyloxanthin, and it could be mis-identified as S. aureus (or S. argenteus) using routine procedures. However, it can be identified based on distinct MLST alleles, and “S. aureus” sequence types ST2470, ST3135, ST3952, ST3960, ST3961, ST3963, ST3965, ST3980, ST4014, ST4075, ST4076, ST4185, ST4326, ST4569, ST6105, ST6106, ST6107, ST6108, ST6109, ST6999 and ST7342 belong to this species.
Cohort Profile: The Shaanxi Blood Donor Cohort in China
Authors: Zhang Lei , Li Hengxin , Su Shu , Wood Erica M. , Ma Ting , Sun Yang , Guo Lingxia , Cheng Qianke , Gu Xiaoyun , Wu Wenjie , Wang Liqin , Ding Miao , Zhang Leilei , Shen Yuan , Yang Jiangcun 
Published: May 2022

PurposeThe Shaanxi Blood Donor Cohort was set up to investigate the impact of blood donation on the health of donors compared with non-blood donors. The specific aims of the study include (1) identifying the geographical and temporal trends of incidence for diseases in both blood donors and non-blood donors; (2) assessing the impact of environmental exposures, lifestyle, body mass index (BMI) and blood type on disease burdens, stratified between blood donors and non-blood donors; and (3) among blood donors, investigating if regular blood donation has a positive impact on donors’ health profiles, based on a cohort with a mixed retrospective and prospective study design.ParticipantsA total of 3.4 million adults, with an equal number and identical demographic characteristics (year of birth, sex and location of residence) of blood donors and non-blood donors, were enrolled on 2012. The one-to-one matching was conducted through a repeated random selection of individuals without any history of blood donation from the Shaanxi Electronic Health Records. The cohort has been so far followed up to the end of 2018, summing to nearly 24 million years of follow-up. The cohort will be followed up prospectively every 3 years until 2030.Findings to DateOf the 1.7 million blood donors, 418,312 (24.5%) and 332,569 (19.5%) individuals were outpatients and inpatients, accounting for 1,640,483(96.2%) outpatient and 496,061 (29.1%) inpatient visits. Of the same number of non-blood donors, 407,798 (23.9%) and 346,097 (20.3%) individuals were hospital outpatients and inpatients, accounting for 1,655,725 (97.1%) outpatient and 562,337 (33.0%) inpatient visits. The number of outpatient and inpatient visits by non-blood donors was 0.9 and 3.9% higher than those of the blood donors (p &lt; 0.01). Blood donors demonstrate significantly fewer inpatients visits than non-blood donors for major chronic disease categories (p &lt; 0.01).Future PlansWe are currently exploring the long term benefits of blood donation on major chronic disease categories and multimorbidities in this large population cohort. The study results are adjusted by the “healthy donor effect.” This cohort study will continue until 2030.
Association of Depression, Antidepressants With Atrial Fibrillation Risk: A Systemic Review and Meta-Analysis
Authors: Fu Yonghui , Feng Shenghui , Xu Yingxiang , Yang Yuanjian , Chen Haibo , He Wenfeng , Zhu Wengen , Yin Kang , Xue Zhengbiao , Wei Bo 
Published: May 2022

BackgroundDepression is a possible influence factor for the increased risk of incident atrial fibrillation (AF). Although several investigations have assessed their association, the results are still controversial. Therefore, we conducted a meta-analysis to evaluate the association between depression or using antidepressants and AF.MethodsWe systemically performed the literature retrieval from two electronic databases PubMed and EMBASE until March 2022 to extract relevant data. The hazard ratios (HRs) and odds ratios (OR) from included studies with 95% confidence intervals (CIs) were adjusted into the risk ratio (RR) and pooled by using the random-effects model.ResultsTotally 9 studies about the associations between depression or antidepressants and incident AF risk were included in this meta-analysis. Among them, 5 studies specifically analyzed the impact of antidepressants on the risk of AF. The outcomes of our analysis indicated that depression or depressive symptoms could increase AF risk (RR = 1.15, 95% CI, 1.03–1.27, P &lt; 0.01). In addition, the use of antidepressants can also increase AF risk (RR = 1.16, 95% CI, 1.07–1.25, P &lt; 0.001). These results remained unchanged when we remove the source of heterogeneity or adjust the analysis model into the fixed-effects model.ConclusionsBased on existing investigations, both depression and the use of antidepressants are closely related to the increase of incident AF risk.
The Bradykinin System Contributes to the Regulation of Prostaglandin-Endoperoxide Synthase 2 Expression in Human Amnion Fibroblasts: Implications for Term and Preterm Birth
Authors: Ni Xiao-tian , Wang Wang-sheng , Liu Yun , Lin Yi-kai , Zhang Fan , Lei Wen-jia , Ling Li-jun , Pan Fan , Zhu Ya-nan , Li Meng-die , Duan Tao , Liu Ming , Sun Kang 
Published: May 2022

BackgroundBradykinin (BK) and its biologically active metabolite des-Arg9 bradykinin (DABK) play a pivotal role in inflammation. Since chorioamnionitis is the leading cause of preterm birth and prostaglandin E2 (PGE2) derived from the amnion is key to labor initiation, we investigated if bradykinin peptides are part of the regulatory network of PGE2 synthesis in human amnion at parturition.MethodsHuman amnion tissue was obtained from term and preterm birth for the study of the changes of the bradykinin system at parturition. Cultured primary human amnion fibroblasts, the major source of PGE2, were used to study the effects of bradykinin peptides on PTGS2 expression and PGE2 production as well as the effects of infection mediators on bradykinin receptors.ResultsBradykinin peptides and their receptors BDKRB1 and BDKRB2 were present in human amnion, and their abundance increased in term and preterm labor. However, transcripts of the genes encoding the bradykinin precursor and its proteolytic cleavage enzymes were hardly detectable in human amnion despite the increased abundance of bradykinin peptides in term and preterm labor, suggesting that there is an alternative source of bradykinin peptides for human amnion and their actions are enhanced in human amnion at parturition. In-vitro studies in cultured human amnion fibroblasts showed that both BK and DABK increased the expression of prostaglandin-endoperoxide synthase 2 (PTGS2), the rate-limiting enzyme in prostaglandin synthesis, and subsequent PGE2 production. These effects of BK and DABK were mediated through BDKRB2 and BDKRB1 receptors, respectively, with subsequent activation of the p38 and ERK1/2 pathways. Moreover, lipopolysaccharide (LPS) and serum amyloid A1 (SAA1), the important mediators of infectious inflammation, induced the expression of both BDKRB1 and BDKRB2 through toll-like receptor 4 (TLR4). Induction of BDKRB1 and BDKRB2 expression by LPS and SAA1 enhanced BK- or DABK-induced PTGS2 expression and PGE2 production in human amnion fibroblasts.ConclusionsThis study demonstrated for the first time that the human amnion is a target tissue of bradykinin peptides and the bradykinin system may be part of the regulatory network of PTGS2 expression and PGE2 production in human amnion fibroblasts at both term and preterm birth, which may be enhanced by infection.
Sexual Dimorphism in the Association of Serum Retinol-Binding Protein-4 With Long-Term Dynamic Metabolic Profiles in Non-Diabetes
Authors: Xiang Jiali , Dai Huajie , Hou Yanan , Wang Qi , Wang Tiange , Li Mian , Zhao Zhiyun , Lu Jieli , Dai Meng , Zhang Di , Xu Yu , Ning Guang , Wang Weiqing , Wang Jiqiu , Bi Yufang , Xu Min 
Published: May 2022

ObjectivesWe aimed to investigate the association of circulating retinol-binding protein-4 (RBP4) levels with long-term cardiometabolic risk profiles and whether sex disparity mattered.MethodsWe included 784 non-diabetic participants aged 40 years and above from a well-defined community-based cohort at baseline in 2005 and they were invited to attend the on-site follow-up examination for two consecutive times with 3-year intervals in 2008 and 2011, respectively. Serum RBP4 was measured at baseline, and the anthropometry and biochemical measurements were performed at each visit. Generalized estimating equation models were used to assess the association of serum RBP4 levels with the dynamic changes in adiposity and glucolipid profile.ResultsBased on all the baseline and the 3- and 6-year follow-up data, baseline serum RBP4 levels (each 1-unit of log10RBP4) were significantly associated with waist circumference [β=3.12, 95% confidence interval (CI) (0.77, 5.47), P=0.01], fasting, and 2-h post-loading glucose [β=0.26 (0.05, 0.47), P=0.02, and 1.70 (1.29, 2.12), P&lt; 0.0001], serum triglycerides [β=0.75, 95% CI (0.54, 0.96), P&lt; 0.0001], total cholesterol [β=0.47, 95% CI [0.23 0.70], P&lt;0.0001), and marginally with body mass index (β=0.97, 95% CI (0.02, 1.93), P=0.046], in total participants, after adjusting potential confounders. The association of RBP4 with 2-h post-loading glucose was stronger in women than that in men [β=1.99, 95% CI (1.49, 2.50) vs. 0.61 (-0.14, 1.36), P for interaction=0.001]. The analysis of change in Z-score of cardiometabolic profiles corresponding to each 1-unit increment in log10RBP4 showed consistent results.ConclusionsHigher RBP4 levels are associated with longitudinal increase in adiposity and deteriorated glucolipid profile defined by repeated measurements. The associations differ in sex regarding to the 2-h post-loading glucose.
Identification of Seasonal and Annual Groundwater Level Trends in Temperate Climatic Conditions
Authors: Minea Ionuț , Boicu Daniel , Amihăiesei Vlad , Iosub Marina 
Published: May 2022

The management of groundwater resources must take into account their variation trends. In this sense, 3 statistical methods were used to identify seasonal and annual groundwater level trends: Mann-Kendall test (MK), Innovative Analysis Method (ITA) and Spearman’s Rho test (SR). Each method was applied for 5 time series (one annual and four seasonal) from 148 hydrological wells from Eastern Romania. The wells were classified in 8 cluster groups based on water depth, using the cluster analysis, covering the full range of depths from under 1.4 to over 15.5 m. Coupling statistical methods (MK and SR test) with one based on graphical analysis (ITA method) offers the possibility of obtaining statistically significant results (between 53% and 69% for spring season, 68% and 96% for autumn season and 68% and 81% from annual values). The decreasing trend of water depth is more obvious for summer and autumn season, for 72%–74% from analyzed wells (based on SR and ITA method) and 68% for annual series (based on MK test). The spatial distribution of seasonal and annual trends highlights that in the northern and central parts of the region, the groundwater depth suffers depletion induced by the effects of prolonged meteorological and hydrological drought manifested in this area in the last decades.
Diversity and Vertical Distribution of Epiphytic Angiosperms, in Natural and Disturbed Forest on the Northern Coast of Jalisco, Mexico
Authors: Flores-Argüelles Alejandra , Espejo-Serna Adolfo , López-Ferrari Ana Rosa , Krömer Thorsten 
Published: May 2022

Background and AimsEpiphytes are an important component of tropical forests, also they are sensitive to disturbance and deforestation caused by humans, since they depend on their host trees and the micro environmental conditions that these provide. The aim of this study was to analyze the differences in species richness, composition, and vertical distribution of epiphytic angiosperms between areas with natural and disturbed forest at the Northern Coast of Jalisco state, Mexico.MethodsThe presence/absence of epiphytic angiosperms was evaluated in each vertical zone of a selected tree, as well as those present in the understory, both in natural and disturbed sites in three types of vegetation (gallery forest, oak forest, tropical semideciduous forest) with a total of 30 plots of 20 m × 20 m in six sites. Alpha diversity was calculated for each site, as well as species turnover (beta diversity) between habitats. An analysis of variance was performed to determine if there was a significant difference in species richness between sites and, also to compare the height and diameter at breast height (DBH) of the host trees. Multivariate analyzes were used to group the sites according to their floristic composition. Furthermore, a linear regression was performed to detect any relationship between the number of species and the phorophyte structure.ResultsWe recorded 45 species, 29 genera and nine families of epiphytic angiosperms. The most diverse families were Bromeliaceae and Orchidaceae and the richest genus was Tillandsia. Although the disturbed sites had more species, a significant difference in richness was not found, except for the disturbed gallery forest. Epiphytic angiosperms presented a high beta diversity, since the sites shared only between 2 and 18% of the recorded species. The inner portion of the canopy (Z3 and Z4) hosted most of the species in all sites and the understory had a high representation of epiphytes except for the disturbed oak forest, where these were absent. A relationship between the DBH and the number of species was found only at the disturbed sites, however, it was highly influenced by the high number of taxa registered in disturbed gallery forest. Therefore, the size of the trees could not be considered a factor in determining the diversity of epiphyte species.ConclusionThe diversity of epiphytic angiosperm species from the North Coast of Jalisco has not been severely affected by the human disturbance. Most of the species have morphological and physiological adaptations that allow their establishment and survival in adverse climatic conditions. Our results suggest that epiphytic angiosperms cannot be considered as a good indicator for natural or disturbed environments in this region but should be considered in environmental conservation, as they present a high beta diversity.
Identification of a Cancer Stem Cells Signature of Head and Neck Squamous Cell Carcinoma
Authors: Wu Zeng-Hong , Li Cheng , Zhang You-Jing , Zhou Wen 
Published: May 2022

Background: Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most widespread and deadly cancer. In recent times, it has been determined that undifferentiated cell populations with stem cell-like properties in HNSCC are major factors influencing recurrence and progression.Method: In this study, we determine key genes related to stemness by merging WGCNA with HNSCC mRNAsi based on the online database.Results: We first download the mRNA expression-based stemness index (mRNAsi) data and contrast the expression levels of mRNAsi in cancers and control samples; we found significantly elevated mRNAsi expressions in HNSCC tissues (p = 0.002). Moreover, the brown module showed a relatively high negative correlation with mRNAsi (cor = -0.8). Thus, we selected the brown module as the interesting module and used it for following analysis. We screened 20 key genes (PDGFRB, PLPP4, CALU, ADAMTS14, COL5A3, KCNE4, LOXL1, CLEC11A, PODN,BGN, AEBP1, COL1A2, LAMA4, LOXL2, LRRC15, THY1, SPON2, COL1A1, NID2, and AC134312.5) including and as to decide the neighbor genes biological interaction network of these 20 stemness-related genes in HNSCC. The top 10 frequent alterations were PIK3CA, FGF3, FGF19, FGF4, DVL3, P3H2, GNB4, COL22A1, COL14A1, and PLOD2.Conclusion: This study showed the critical role of stemness-related genes in HNSCC. However, more related studies are needed to confirm these results.