bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical impact of radiotherapy protocol compliance and quality in the treatment of retroperitoneal sarcomas: Results from the EORTC 62092‐22092 STRASS trial
Authors: Haas Rick , Stelmes Jean‐Jacques , Zaffaroni Facundo , Sauvé Nicolas , Clementel Enrico , Bar‐Deroma Raquel , Le Péchoux Cécile , Litière Saskia , Marreaud Sandrine , Alyamani Najlaa , Andratschke Nicolaus H. J. , Sangalli Claudia , Chung Peter W. , Miah Aisha , Hurkmans Coen , Gronchi Alessandro , Bovée Judith V. M. G. , Gelderblom Hans , Kasper Bernd , Weber Damien Charles , Bonvalot Sylvie 
Published: May 2022

BackgroundThe European Organization for Research and Treatment of Cancer 22092‐62092 STRASS trial failed to demonstrate the superiority of neoadjuvant radiotherapy (RT) over surgery alone in patients with retroperitoneal sarcoma. Therefore, an RT quality‐assurance program was added to the study protocol to detect and correct RT deviations. The authors report results from the trial RT quality‐assurance program and its potential effect on patient outcomes.MethodsTo evaluate the effect of RT compliance on survival outcomes, a composite end point was created. It combined the information related to planning target volume coverage, target delineation, total dose received, and overall treatment time into 2 groups: non–RT‐compliant (NRC) for patients who had unacceptable deviation(s) in any of the previous categories and RT‐compliant (RC) otherwise. Abdominal recurrence‐free survival (ARFS) and overall survival were compared between the 2 groups using a Cox proportional hazard model adjusted for known prognostic factors.ResultsThirty‐six of 125 patients (28.8%) were classified as NRC, and the remaining 89 patients (71.2%) were classified as RC. The 3‐year ARFS rate was 66.8% (95% confidence interval [CI], 55.8%‐75.7%) and 49.8% (95% CI, 32.7%‐64.8%) for the RC and NRC groups, respectively (adjusted hazard ratio, 2.32; 95% CI, 1.25‐4.32; P = .008). Local recurrence after macroscopic complete resection occurred in 13 of 89 patients (14.6%) versus 2 of 36 patients (5.6%) in the RC and NRC groups, respectively.ConclusionsThe current analysis suggests a significant benefit in terms of ARFS in favor of the RC group. This association did not translate into less local relapses after complete resection in the RC group. Multidisciplinary collaboration and review of cases are critical to avoid geographic misses, especially for rare tumors like retroperitoneal sarcoma.
ARmed question answering system
Authors: Fehri Hela , Dardour Sondes , Haddar Kais 
Published: May 2022

SummaryQuestion answering, retrieving an exact answer to a question posed in natural language, is an issue which has widely been studied in the open domain over the last decades. This, however, remains a real challenge in the medical domain as most existing systems only support a limited amount of question and answer types. The problem with proposed methods for Arabic language in the medical domain is that there is often a conflict between the extracted answer and user's requirements. This conflict is related to ambiguity. Nevertheless, the method we propose has successfully tackled this problem. Thus, in this article, we introduce ARmed, a system for automatically answering medical questions for Arabic language. ARmed consists of corpora study, pre‐processing, question analysis, documents/passages retrieval, and answer extraction. Compared with the previous studies, ARmed has the potential to handle a large number of questions and answer types. The experimental results show that ARmed achieves interesting results.
New Luminescent Lanthanide Tetrakis‐Complexes NEt4[LnL4] Based on Dimethyl‐N‐Benzoylamidophosphate
Authors: Kariaka Nataliia S. , Trush Victor A. , Dyakonenko Viktoriya V. , Shishkina Svitlana V. , Smola Sergii S. , Rusakova Nataliia V. , Sliva Tetiana Y. , Gawryszewska Paula , Carneiro Neto Albano N. , Malta Oscar L. , Amirkhanov Vladimir M. 
Published: May 2022

AbstractNew lanthanide dimethyl‐N‐benzoylamidophosphate (HL) based tetrakis‐complexes NEt4[LnL4] (Ln3+=La, Nd, Sm, Eu, Gd, Tb, Dy) are reported. The complexes are characterized by means of NMR, IR, absorption, and luminescent spectroscopy as well as by elemental, X‐Ray, and thermal gravimetric analyses. The phenyl groups of the four ligands of the complex anion are directed towards one side, while the methoxy groups are directed in the opposite side, which makes the complexes under consideration structurally similar to calixarenes. The effect of changing the alkali metal counterion to the organic cation NEt4+ on the structure and properties of the tetrakis‐complex [LnL4]‐ is analyzed. The complexes exhibit bright characteristic for respective lanthanides luminescence. Rather high intensity of the band of 5D0→7F4 transition, observed in the luminescence spectrum of NEt4[EuL4], is discussed based on theoretical calculations.
Depicting the role of cross‐cultural legitimacy for responsible innovation in Asian‐Pacific business models: A dialectical systems view of Yin‐Yang harmony
Authors: Chin Tachia , Caputo Francesco , Shi Yi , Calabrese Mario , Aouina‐Mejri Chiraz , Papa Armando 
Published: May 2022

AbstractRecognizing the key role of innovation in ensuring the definition of managerial and organizational model able to support companies in facing the multiple challenges of sustainable development, the paper focuses on the domain of Responsible innovation (RI) with the aim to depict the role of cross‐cultural legitimacy for RI in Asian‐Pacific business models. Adopting the interpretative lens provided by Dialectical Systems View, the Yin‐Yang dichotomy is discussed for depicting the relationships among focal firms and stakeholders within in Asian‐Pacific cross‐cultural models. Hypotheses are tested via constructed stepwise regression models using secondary data related to a sample of large Chinese MNEs listed in the Shanghai and Shenzhen stock exchanges over the period from 2009 to 2018. The research shows the multiple influences that cultural legitimacy has in influencing RI and firm performance in the Asian‐Pacific cross‐cultural business models. Thanks to the study, the current debate about the role of innovation in supporting the definition of sustainable‐based business models is enriched through the definition of cross‐cultural legitimacy as key driver for RI in Asian‐Pacific business models. Thanks to the reflections herein, RI is definitely approached as a holistic domain whose understanding requires to researchers and practioners to overcome traditional business “boundaries.”
Controlled Supramolecular Assembly of Gold (III) Amphiphiles in Aqueous Media
Authors: Jiang Jia‐Jun , Chau Anson Kwok‐Hei , Wong Man‐Kin , Leung Franco King‐Chi 
Published: May 2022

AbstractSupramolecular assemblies of gold complex‐based amphiphiles in aqueous media are highly structural sensitive to external environments, providing an attractive prospect for its application in soft functional materials. Notably, the development of a supramolecular assembly transformation of gold (III) amphiphiles directly controlled by counterion exchange is of fundamental importance for exerting the full potential of dynamic supramolecular assembly by external stimuli. Here we present a reversible supramolecular assembly of gold (III) amphiphiles controlled by counterions in aqueous media and their co‐assembly with gold nanoparticles.
Radical Deoxyfunctionalisation Strategies**
Authors: Anwar Khadijah , Merkens Kay , Aguilar Troyano Francisco José , Gómez‐Suárez Adrián 
Published: May 2022

AbstractDue to their abundance and readily available synthesis, alcohols provide ideal handles for the selective derivatisation of organic molecules. Radical chemistry offers versatile strategies for the conversion of Csp3−O bonds into a wide range of Csp3−C, Csp3−H, or Csp3−heteroatom bonds. In these reactions, alcohols are readily derivatised with an activator group which can undergo facile mesolysis to generate a primary, secondary, or tertiary open‐shell species that can engage in further transformations. These strategies are particularly effective at overcoming steric limitations associated with nucleophilic substitution pathways. Despite their potential, the use of radical deoxyfunctionalisation reactions as a general strategy for the synthesis of useful and complex molecules remains underutilised. In this Review, we highlight recent advancements in this exciting field in which photocatalysis, transition metal catalysis or electrochemistry are used to initiate the radical processes.
A new method for operating point free power system transient stability situational awareness based on single machine equivalent approach
Authors: Batchu Sreenadh , Teeparthi Kiran 
Published: May 2022

AbstractTransient stability assessment is an essential element for situational awareness and decision making process of a power system operator in maintaining the secure operation. Continuous efforts have been made for devising methods to assess the transient stability. However, the existing methods have dependency on pre‐fault operating condition. This article aims to report a new method, towards deriving contingency wise operating point free transient stability assessment. The method is based on single machine equivalent (SIME) approach and has two phases (a) off line tuning (b) online application. In offline tuning phase each plausible contingency is characterized by an operating point free parameter called mean critical return angle over the specified operating region. In online application phase, transient stability for a given plausible contingency is predicted using SIME approach. Two new severity indices namely stable severity index and unstable severity index are proposed and evaluated for assessing the degree of stability and instability. Further, these indices are used in contingency screening. The proposed method is tested on 3‐machine 9‐bus system and, 10‐machine 39‐bus system. Results shows that the proposed method is simple and can aid the existing methods in providing reliable transient stability situational awareness to the system operator.
Development, verification, and validation of comprehensive acoustic fluid‐structure interaction capabilities in an open‐source computational platform
Authors: Dhulipala Somayajulu L. N. , Bolisetti Chandrakanth , Munday Lynn B. , Hoffman William M. , Yu Ching‐Ching , Mir Faizan Ul Haq , Kong Fande , Lindsay Alexander D. , Whittaker Andrew S. 
Published: May 2022

AbstractThe acoustic fluid‐structure interaction (FSI) formulation is a practical numerical approach for the seismic analysis of fluid‐filled tanks. However, there are no verification and validation studies reported in the literature that demonstrate the ability of an acoustic FSI numerical model to predict responses important to structural and mechanical design for intense translational and rotational earthquake inputs. Herein, an acoustic FSI formulation is implemented in the open‐source Multiphysics Object‐Oriented Simulation Environment (MOOSE), and is formally verified and validated using analytical solutions and code‐to‐code verification, and experimental data, respectively. The analytical solutions are for small amplitude, unidirectional seismic inputs. The code‐to‐code verification utilizes a previously verified and validated Arbitrary Lagrangian‐Eulerian (ALE) numerical model in the commercial finite element code LS‐DYNA. The validation studies utilize a comprehensive data set assembled from results of 3D earthquake‐simulator tests of a fluid‐filled vessel. The acoustic numerical model in MOOSE is verified and validated for hydrodynamic pressures and support reactions except for cases that involve significant convective response. For small amplitude inputs, numerically predicted wave heights match those of the analytical solutions. The numerical model is not verified and validated for wave height calculations under intense 3D seismic inputs. The run times for the acoustic FSI simulations in MOOSE are an order of magnitude, or more, shorter than for the corresponding ALE simulations in LS‐DYNA. The utility of the MOOSE acoustic FSI implementation is demonstrated by seismic analysis of a building equipped with a fluid‐filled, advanced nuclear reactor.
The role of astrocyte structural plasticity in regulating neural circuit function and behavior
Authors: Lawal Oluwadamilola , Ulloa Severino Francesco Paolo , Eroglu Cagla 
Published: May 2022

AbstractBrain circuits undergo substantial structural changes during development, driven by the formation, stabilization, and elimination of synapses. Synaptic connections continue to undergo experience‐dependent structural rearrangements throughout life, which are postulated to underlie learning and memory. Astrocytes, a major glial cell type in the brain, are physically in contact with synaptic circuits through their structural ensheathment of synapses. Astrocytes strongly contribute to the remodeling of synaptic structures in healthy and diseased central nervous systems by regulating synaptic connectivity and behaviors. However, whether structural plasticity of astrocytes is involved in their critical functions at the synapse is unknown. This review will discuss the emerging evidence linking astrocytic structural plasticity to synaptic circuit remodeling and regulation of behaviors. Moreover, we will survey possible molecular and cellular mechanisms regulating the structural plasticity of astrocytes and their non‐cell‐autonomous effects on neuronal plasticity. Finally, we will discuss how astrocyte morphological changes in different physiological states and disease conditions contribute to neuronal circuit function and dysfunction.
Patterns of kidney dysfunction in acute‐on‐chronic liver failure: Relationship with kidney and patients’ outcome
Authors: Napoleone Laura , Solé Cristina , Juanola Adrià , Ma Ann T. , Carol Marta , Pérez‐Guasch Martina , Rubio Ana‐Belén , Cervera Marta , Avitabile Emma , Bassegoda Octavi , Gratacós‐Ginès Jordi , Morales‐Ruiz Manuel , Fabrellas Núria , Graupera Isabel , Pose Elisa , Crespo Gonzalo , Solà Elsa , Ginès Pere 
Published: May 2022

Abstract
Impairment of kidney function is common in acute‐on‐chronic liver failure (ACLF). Patterns of kidney dysfunction and their impact on kidney and patient outcomes are ill‐defined. Aims of the current study were to investigate patterns of kidney dysfunction and their impact on kidney and patient outcomes in patients with acute decompensation (AD) of cirrhosis, with or without ACLF. This prospective study includes 639 admissions for AD (232 with ACLF; 407 without) in 518 patients. Data were collected at admission and during hospitalization, and patients were followed up for 3 months. Urine samples were analyzed for kidney biomarkers. Most patients with ACLF (92%) had associated acute kidney injury (AKI), in most cases without previous chronic kidney disease (CKD), whereas some had AKI‐on‐CKD (70% and 22%, respectively). Prevalence of AKI in patients without ACLF was 35% (p < 0.001 vs. ACLF). Frequency of CKD alone was low and similar in both groups (4% and 3%, respectively); only a few patients with ACLF (4%) had no kidney dysfunction. AKI in ACLF was associated with poor kidney and patient outcomes compared with no ACLF (AKI resolution: 54% vs. 89%; 3‐month survival: 51% vs. 86%, respectively; p < 0.001 for both). Independent predictive factors of 3‐month survival were Model for End‐Stage Liver Disease–Sodium score, ACLF status, and urine neutrophil gelatinase–associated lipocalin (NGAL). AKI is almost universal in patients with ACLF, sometimes associated with CKD, whereas CKD alone is uncommon. Prognosis of AKI depends on ACLF status. AKI without ACLF has good prognosis. Best predictors of 3‐month survival are MELD‐Na, ACLF status, and urine NGAL.
Changing associations between socioeconomic status and self‐reported discrimination from the 1990s to the 2010s in the United States
Authors: Jokela Markus , Fuller‐Rowell Thomas E. 
Published: May 2022

We examined whether prevalence of social class discrimination—and its association with psychological distress—has changed between 1990s and 2010s in the United States. Data were from the original Midlife in the United States (MIDUS) study with data collections in 1995–1996 (n = 2931) and 2004–2005 (n = 1708), and the new MIDUS Refresher sample from 2011 to 2014 (n = 2543). Socioeconomic status (SES) became more strongly associated with self‐rated discrimination over time, with individuals with the lowest SES experiencing more discrimination (B = 0.75, p < .001) and those with the highest SES less discrimination (B = 0.36, p < .001) over time: at baseline, the difference in self‐rated discrimination between the highest and lowest SES groups was 15.3% versus 10.8% (4.7% point difference). This difference increased to 20.0% versus 7.4% in the last study wave (12.6% point difference). Association between self‐reported discrimination and psychological distress strengthened over time, but the associations between socioeconomic indicators and distress did not change. The results suggest that people with low SES had higher risk of encountering unfair and disrespectful treatment in the 2010s compared to the 1990s.
Japanese giant benign prostatic hyperplasia: Sibling cases
Authors: Ohyama Takehiro , Endo Fumiyasu , Shimbo Masaki , Hattori Kazunori 
Published: May 2022

IntroductionThe pathophysiology of benign prostatic hyperplasia (BPH) remains incompletely understood but is likely multifactorial. Inflammation and metabolic factors may increase the risk of BPH. Several studies have evaluated the possible roles played by genetic factors. Here, we describe two cases of suspected familial BPH.Case presentationsWe report the cases of two brothers, aged 77 and 69 years, with giant BPH. As both exhibited urinary retention, we performed Holmium Laser Enucleation of the Prostate (HoLEP) and obtained tissue samples weighing 276 g and 153 g, respectively. The postoperative courses were good.ConclusionWe experienced two cases of sibling BPH with volumes exceeding 200 mL and successfully treated them with HoLEP.
The context and development of the early relational health screen
Authors: Willis David W. , Condon Marie‐Celeste , Moe Vibeke , Munson Leslie , Smith Lars , Eddy J. Mark 
Published: May 2022

AbstractEarly relational experiences are key drivers for developing social emotional capacities, educational achievement, mental health, physical health, and overall wellbeing. The child health sectors are committed to promotion, prevention, and early intervention that optimize children's health and development, often employing evidence‐based screening as foundational practices. Despite a variety of validated parent‐infant observational assessment tools, few are practical within busy practice settings, acceptable with all racial and ethnic groups and ready for universal adoption. In response to this need, a team of clinicians, early childhood educators, researchers and infant mental health specialists collaborated to develop and test a novel video‐based, dyadic relational screening and monitoring tool, the Early Relational Health Screen (ERHS). This tool uniquely focuses on the early parent‐child relationship (6–24 months), within the construct of early relational health (ERH). Initial testing demonstrated that the ERHS is a valid, reliable, feasible, and useful screening and monitoring tool for clinical applications. The ERHS was further developed within a population‐based, prospective research study and adapted with brief video feedback for parents in the home visiting and child health sectors. The ERHS and its adaptations appear to advance ERH and equity within the transforming child health and public health care systems of today.
CYP2S1 rs338599 polymorphism confers reduced risk to anti‐tuberculosis drug‐induced liver injury and may be a novel marker for its risk prediction
Authors: Wang Liyuan , Wang Hui , Qi Ying 
Published: May 2022

AbstractPurposeIn the present study, we would like to explore whether Cytochrome P450 2S1 (CYP2S1) rs338599 polymorphism confers risk to anti‐tuberculosis drug‐induced liver injury (ADLI) and provide evidence of being used as novel marker for ADLI risk prediction.Patients and methodsA total of 162 pulmonary tuberculosis patients admitted to Affiliated Hospital of Hebei University from August 2018 to March 2021 were selected. Patients who developed into ADLI were assigned as ADLI group (n = 50), and those who did not developed into ADLI were assigned as non‐ADLI group (n = 112). The CYP2S1 rs338599 polymorphism was detected by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) method using binary logistic regression analyses through adjusting for age and sex.ResultsNo difference was detected in age, sex, smoking status, profession, education level, marital status, alcohol consumption, or using liver‐protecting drugs (p > 0.05). Compared with non‐ADLI group, GG genotype and G allele were significantly higher in ADLI group (p < 0.05).ConclusionOur results indicated that CYP2S1 rs338599 polymorphism conferred reduced risk to ADLI. The tuberculosis patients who had GG genotype or G allele were not susceptible to ADLI. CYP2S1 rs338599 polymorphism may be a novel marker for ADLI risk prediction.
Extracellular vesicles enclosed‐miR‐421 suppresses air pollution (PM2.5)‐induced cardiac dysfunction via ACE2 signalling
Authors: Wang Hongyun , Wang Tianhui , Rui Wei , Xie Jinxin , Xie Yuling , Zhang Xiao , Guan Longfei , Li Guoping , Lei Zhiyong , Schiffelers Raymond M , Sluijter Joost P G , Xiao Junjie 
Published: May 2022

AbstractAir pollution, via ambient PM2.5, is a big threat to public health since it associates with increased hospitalisation, incidence rate and mortality of cardiopulmonary injury. However, the potential mediators of pulmonary injury in PM2.5‐induced cardiovascular disorder are not fully understood. To investigate a potential cross talk between lung and heart upon PM2.5 exposure, intratracheal instillation in vivo, organ culture ex vivo and human bronchial epithelial cells (Beas‐2B) culture in vitro experiments were performed respectively. The exposed supernatants of Beas‐2B were collected to treat primary neonatal rat cardiomyocytes (NRCMs). Upon intratracheal instillation, subacute PM2.5 exposure caused cardiac dysfunction, which was time‐dependent secondary to lung injury in mice, thereby demonstrating a cross‐talk between lungs and heart potentially mediated via small extracellular vesicles (sEV). We isolated sEV from PM2.5‐exposed mice serum and Beas‐2B supernatants to analyse the change of sEV subpopulations in response to PM2.5. Single particle interferometric reflectance imaging sensing analysis (SP‐IRIS) demonstrated that PM2.5 increased CD63/CD81/CD9 positive particles. Our results indicated that respiratory system‐derived sEV containing miR‐421 contributed to cardiac dysfunction post‐PM2.5 exposure. Inhibition of miR‐421 by AAV9‐miR421‐sponge could significantly reverse PM2.5‐induced cardiac dysfunction in mice. We identified that cardiac angiotensin converting enzyme 2 (ACE2) was a downstream target of sEV‐miR421, and induced myocardial cell apoptosis and cardiac dysfunction. In addition, we observed that GW4869 (an inhibitor of sEV release) or diminazene aceturate (DIZE, an activator of ACE2) treatment could attenuate PM2.5‐induced cardiac dysfunction in vivo. Taken together, our results suggest that PM2.5 exposure promotes sEV‐linked miR421 release after lung injury and hereby contributes to PM2.5‐induced cardiac dysfunction via suppressing ACE2.