bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal Variation of Congenital Diaphragmatic Hernia: A Review of the Literature and Database Report from the United States and Canada
Authors: Doktor Fabian , Antounians Lina , Miller Jason , Harb Maria , Meats Tracy , Bercovitch Rachel , Ireland Dawn , Zani Augusto 
Published: July 2022

Abstract
Introduction The etiology of congenital diaphragmatic hernia (CDH) remains unknown and only 10 to 30% of patients have a genetic cause. Seasonal variation is known to contribute to the development of some congenital anomalies. Our aim was to investigate whether CDH births have seasonal variation.
Materials and Methods A literature review was conducted for CDH and seasonality. Moreover, data from the CDH International Patient Registry Database were collected for infants with due dates between 2008 and 2014. Due dates were used to determine seasonal distribution of births. Birth rates per month in the United States and Canada were extracted from publicly available databases. Data were analyzed using analysis of variance and contingency tables.
Results First, the literature review revealed 11 articles, of which 3 were eligible for inclusion. These studies reported conflicting results on seasonality of CDH. Second, we extracted due dates from the CDH International Patient Registry Database (1,259 patients) and found that there were fewer due dates in winter months (12.1 ± 4 patients/month) than in summer (16.7 ± 6 patients/month; p = 0.011) and fall months (16.3 ± 5 patients/month; p = 0.022). Although this trend was similar to that of all births in the United States and Canada, a lower incidence was observed in winter for CDH infants (20.2%) than for the general population (24.1%, p = 0.0012). CDH survival rate did not vary by season.
Conclusion This study provides evidence for a seasonal variation of CDH births. No causative link was established between CDH development and seasonality. Population-based studies with a focus on exposome data are needed to explain seasonal variation in CDH.
Routine Maternal Vaccine Uptake during the COVID-19 Pandemic
Authors: Cotter Savannah , Taylor Lauren , Grace Rebecca , Miao Di , Ratan Bani M. 
Published: July 2022

Objective This study examines the impact of the coronavirus disease 2019 (COVID-19) pandemic on influenza and tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine uptake in a pregnant, low-income population.
Study Design This retrospective cohort study included women initiating prenatal care before (May–November 2019) or during the COVID-19 pandemic (May–November 2020) at two large Medicaid clinics. All patients entered prenatal care before 20 weeks and delivered full-term. Medical records were reviewed for vaccine uptake and demographic data. Multivariate logistic regression analysis was used to compare vaccination rates prior to and during the COVID-19 pandemic. Additional analysis was performed to identify association of demographic factors with vaccine uptake. IRB approval was obtained for this study.
Results A total of 939 patients met inclusion criteria, with 462 initiating care prior to and 477 initiating care during the COVID-19 pandemic. Influenza vaccination uptake was 78% (362/462) in the prepandemic group, significantly decreasing to 61% (291/477) in the pandemic group (p <0.01, odds ratio [OR] = 0.38, confidence interval [CI]: 0.26–0.53). Tdap vaccination uptake was 85% (392/462) in the prepandemic group, significantly decreasing to 76% (361/477) in the pandemic group (p <0.01, OR = 0.56, CI: 0.40–0.79). The decrease in influenza vaccine uptake was most significant in non-Hispanic Black patients, decreasing from 64% (73/114) in the prepandemic group to 35% (35/101) in the pandemic group (p <0.01, OR = 0.30, CI: 0.17–0.52), while there was no significant difference in age or parity in relation to vaccination status.
Conclusion Routine vaccination uptake significantly decreased during the COVID-19 pandemic in a low-income population of pregnant women, with decrease more pronounced on influenza vaccine than on Tdap vaccine uptake, especially in non-Hispanic Black patients.
Key Points
Development and Validation of a Neonatal Physical Maturity Score for Low- and Middle-Income Countries
Authors: Krishnan Vaisakh , Kumar Vijay , Vegda Hemadri , Ujjanappa Vidya , Manari Anju , Thamunni Ajithkumar V. , P. Ashraf T. , Devadas Sahana , Fattepur Sudindrashayana , Basett Paul , Thayyil Sudhin 
Published: July 2022

Objective Currently available gestational age scoring systems are complex and inaccurate for wider use in low- and middle-income countries (LMIC), particularly in infants with neonatal encephalopathy. Here, we aimed to develop a scoring system based on physical characteristics for identifying late preterm infants from term infants.
Study Design This was a prospective observational study conducted in 2 phases- the discovery phase and validation phase. In the first phase, we examined the accuracy of 10 objective physical characteristics in a prospective cohort of 1,006 infants recruited from three hospitals in South India. A weighted scoring system and a photo card were then developed based on the six best performing characteristics which were validated in another prospective cohort of 1,004 infants.
Results The final score had a sensitivity of 66.0% (95% confidence intervals [CIs], 58.4–73.8%), specificity of 80.0% (95% CI, 77.2–82.7%), and a negative predictive value of 93.0% (95% CI, 90.5–94.5%).
Conclusion This scoring system may have wider applications in LMIC, particularly in community settings and in infants with neonatal encephalopathy.
Key Points
Delayed Aspiration of Air Emboli from the Central Venous Catheter in a Case of Suspected Massive Venous Air Embolism: A Therapeutic Success
Authors: Khandelwal Ankur , Nayak Sudhansu S. , Bhatia Anshil , Shrivastava Amit K. , Bhardwaj Vikas 
Published: July 2022

AbstractVenous air embolism (VAE), though, clinically benign in majority of cases, the significant ones can lead to life-threatening cardiopulmonary and neurological consequences. Though studies mention the success rate of only 6 to 16% in aspirating air from the central venous catheter (CVC) during VAE, the technique is very specific for diagnosing VAE and has high therapeutic significance. We report a case in which delayed aspiration of air emboli from the CVC in suspected massive VAE during decompressive craniectomy resulted in rapid resolution of hemodynamic instability. If not inserted previously, CVC may be considered in a hemodynamically unstable patient with suspected VAE.
Understanding How Older Adults with Communication Difficulties Access Health Services: What We Can Learn from the National Health and Aging Trends Study (NHATS)
Authors: Baylor Carolyn , Brown Cait , Mroz Tracy M. , Burns Michael 
Published: July 2022

AbstractPeople with communication disorders face barriers to accessing safe and respectful healthcare. These barriers result in increased healthcare complications and inefficiencies, both of which contribute to increased healthcare costs. One obstacle to advocating for accommodations that could improve healthcare for this population is the absence of cost effectiveness studies of such accommodations specifically, as well as a paucity of data defining the needs of this population in general. The purpose of this study was to explore how people with communication and swallowing difficulties are characterized in the National Health and Aging Trends Study (NHATS), a nationally representative survey of Medicare beneficiaries aged 65 and older, and how they manage their healthcare. Cross-sectional data from the NHATS rounds 5 to 9 (2015–2019) resulted in 8,038 unique respondents, 3,243 of who reported speech, memory, hearing, and/or swallowing difficulties. More than 90% of respondents with communication difficulties reported having a regular doctor. Less than 60% of respondents with communication difficulties had a family member or caregiver go to medical appointments with them, and around 70% of that subset of participants received help from that caregiver with communication during appointments. Fewer than 15% of respondents with communication difficulties used the internet for healthcare communication or information. Less than 5% of respondents across all communication difficulty categories had received rehabilitation services for communication in the year prior to their survey responses. While the information gleaned from NHATS points to likely gaps between the needs people with communication disorders may have for safe and accessible healthcare, and the support available, future research is needed to improve and clarify how communication disorders are defined and characterized in large-scale surveys to generate more interpretable data. These stronger empirical foundations are needed to support cost-effectiveness analyses to advocate for better communication accessibility of healthcare settings.
Pediatric Microcuff Tube for Neurosurgical Procedures: A Boon or Bane?
Authors: Thakkar Keta , Sethuraman Manikandan , Hrishi Ajay P. 
Published: July 2022

AbstractPediatric Microcuff endotracheal tubes have come into vogue in the last few years. It overcomes the problems faced with the uncuffed or conventional cuffed tubes used in the pediatric population. In addition, the more distal placement of the polyurethane cuffs in these tubes eliminates the risk of airway mucosal injury and hence postoperative stridor. This makes it an attractive option for neurosurgical patients where there is a high incidence of cranial nerve deficit, airway edema, and the requirement of prolonged postoperative ventilation. But due to this particular design, Murphy's eye is not incorporated in the tube, which can potentially hamper ventilation, especially when used for long duration surgery. With the help of our case report, we would like to warn the readers regarding this life-threatening complication that resulted in hypoxia in a 1-year-old child in the postoperative period.
Retrospective Analysis of 1998 Patients Diagnosed with Brain Death between 2011 and 2019 in Turkey
Authors: Sipahioglu Hilal , Elay Gulseren , Bingol Nezahat , Bahar Ilhan 
Published: July 2022

Abstract
Background Organ transplantation reduces mortality and morbidity in patients with end-stage organ failure. The number of living organ donations is not enough to meet the current organ transplantation need; therefore, there is an urgent need for organ donation from cadavers. We aimed to determine the organ donation rates and reveal the obstacles against donation.
Methods This study is designed as a retrospective multicenter study consisting of eight university hospitals, three training and research hospitals, 26 state hospitals, and 74 private hospitals in nine provinces in Turkey. A total of 1,998 patients diagnosed with brain death between January 2011 to April 2019 were examined through the electronic medical records data system.
Results Median patient age was 38 (IQR: 19–57), and 1,275 (63.8%) patients were male. The median time between the intensive care unit admission and brain death diagnosis was 56 (IQR:2–131) hours. The most commonly used confirmatory diagnostic test was computed tomography in 216 (30.8%) patients, and the most common cause of brain death was intraparenchymal hemorrhage with 617 (30.9%) patients. A total of 1,646 (82.4%) families refused to permit organ donation. The most common reasons for refusal were family disagreement (68%), social/relative pressure (24%), and religious beliefs (8%).
Conclusions Many families refuse permission for organ donation; some of the provinces included in this study experienced years of exceptionally high refusal rates.
Incidence and Perioperative Risk Factors of Delayed Extubation following Pediatric Craniotomy for Intracranial Tumor: A 10-Year Retrospective Analysis in a Thailand Hospital
Authors: Sangtongjaraskul Sunisa , Yuwapattanawong Kornkamon , Sae-phua Vorrachai , Jearranaiprepame Thichapat , Paarporn Paweena 
Published: July 2022

Abstract
Background The determination of extubation (early or delayed) after pediatric craniotomy for intracranial tumor should be carefully considered because each has its pros and cons. The aim of this study was to investigate the incidence of the delayed extubation in these patients. The secondary goal was to identify the perioperative factors influencing the determination of delayed extubation.
Methods This retrospective study was performed in pediatric patients with intracranial tumor who underwent craniotomy at a university hospital between April 2010 and March 2020. Preoperative and intraoperative variables were examined. The variables were compared between the delayed extubation and early extubation group.
Results Forty-two of 286 pediatric patients were in the delayed extubation group with an incidence of 14.69%. According to multivariate analyses, the risk factors that prompted delayed extubation were the intracranial tumor size ≥ 55 mm (adjusted odds ratio [AOR], 2.338; 95% confidence interval [CI], 1.032–5.295; p = 0.042), estimated blood loss (EBL) ≥ 40% of calculated blood volume (AOR, 11.959; 95% CI, 3.457–41.377; p < 0.001), blood transfusion (AOR, 3.093; 95% CI, 1.069–8.951; p = 0.037), duration of surgery ≥ 300 minutes (AOR, 2.593; 95% CI, 1.099–6.120; p = 0.030), and completion of the operation after working hours (AOR, 13.832; 95% CI, 2.997–63.835; p = 0.001).
Conclusions The incidence of delayed extubation after pediatric craniotomy was 14.69%. The predictive factors were the size of tumor ≥ 55 mm, EBL ≥ 40% of calculated blood volume, blood transfusion, duration of surgery ≥ 300 minutes, and completion of surgery after routine working hours.
Streptococcus gallolyticus Bacteremia Detected in Apheresis Platelets and Its Link to Colonic Neoplasms
Authors: Lemanski Francisco Costa Beber , Barp Anna Laura Duro , Hammacher Gabriela Kohl , Cas Martina Estacia Da , Wink Cristine Moratelli , Voloski Ana Paula dos Santos , Pasqualotti Adriano , Araújo Cristiane da Silva Rodrigues de 
Published: July 2022

AbstractIntroduction Streptococcus gallolyticus belongs to the Streptococcus bovis complex, and it is a common bacterium colonizing the gastrointestinal tract. Its presence in the blood may suggest an underlying pathology such as a colonic neoplasm. We report herein a case of S. bovis bacteremia in an apheresis platelet donor, review similar cases in the literature, and suggest a flowchart for the management of similar cases in other blood donation centers.Case Presentation A 61-year-old subject presented to a Hemotherapy Service to make an apheresis platelet donation. On quality control testing, S. gallolyticus was identified in hemoculture, and the donor was called back for follow-up. At first, a new hemoculture was requested, and the patient was referred to the outpatient department of infectious diseases to further investigate pathologies associated with S. gallolyticus. A subsequent colonoscopy investigation evidenced a polypoid structure in the ascending colon. Pathology reported the resected specimen as a low-grade tubular adenoma.Conclusion Isolation of S. bovis in blood products requires further investigation and should be managed with precision by Hemotherapy Services. A standard protocol for the management of asymptomatic patients with S. bovis positive hemoculture, with the requests of a new blood culture, a colonoscopy, and an echocardiogram is crucial, as it may ensure early diagnosis and reduce morbidity and mortality.
Chlamydia home sampling in the real world: a cross-sectional analysis
Authors: Foster Rosalind , Vickers Tobias , Lu Heng , McNulty Anna 
Published: July 2022

Background Retesting rates for chlamydia in Australia are low. Chlamydia home sampling has been shown to increase retesting rates. Sydney Sexual Health Centre introduced chlamydia home sampling in 2019. The aim of this study is to describe home sampling in a real world setting. Methods In this retrospective study, the total number of heterosexual males and non-sex-working females who tested positive for chlamydia at a urogenital site (1 November 2019 to 31 October 2020) were identified based on local diagnostic codes. Agreeing participants who were sent a home sampling SMS reminder at 2.5 months were included for further analysis. Descriptive statistics and attrition rates of the home sampling were calculated using frequencies and percentages. Bivariate analyses of the main covariates by each stage, assessing crude associations, were performed using chi-squared tests. Results A total of 444 people attending Sydney Sexual Health Centre were eligible for the chlamydia home sampling option, 25.9% agreed to be sent the home sampling SMS invitation, of which 53 (46.1%) replied and were mailed a home sampling kit, with 43.4% returning the kit; of these 3 (13.0%) were positive for chlamydia. The majority (91.3%) of tests were performed within 6 months of original diagnosis. Of those who initially agreed but then did not undertake home sampling, 22.6% subsequently tested in clinic at Sydney Sexual Health Centre. There were no associations between any of the variables measured and undertaking home sampling. Conclusions Home sampling process for chlamydia reinfection screening in heterosexual men and non-sex-working women had much lower uptake than seen in a previous trial with high attrition rates at each stage.
Key comparison BIPM.RI(I)-K2 of the air-kerma standards of the GUM, Poland, and the BIPM in low-energy x-rays
Authors: Burns D T , Kessler C , Michalik Ł 
Published: July 2022

Main text
A key comparison has been made between the air-kerma standards of the GUM, Poland, and the BIPM in the low-energy x-ray range. The results show the standards to be in agreement at the level of the expanded uncertainty of the comparison of 5.8 parts in 103. The results are analysed and presented in terms of degrees of equivalence, suitable for entry in the BIPM key comparison database.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Matrix shaped plasmonic hybrid nanostructure with direction-dependent functionality for multianalyte detection and biosensing
Authors: S Simitha , Francis Shinto M , Ramachandran Ajith , Jacob Jesly , Thomas Vibin Ipe 
Published: July 2022

Abstract
A Surface plasmon resonance based hybrid nanosystem with the competence of single and multiple analytes analysis is demonstrated using a symmetry modified sensory platform for promising application in biosensing. Plasmonic properties of the designed 2 × 2 matrix system arising from higher-order plasmonic modes generated near groove positions in the structure are analyzed numerically and calibrated for enhanced sensor performance and multi-functionality. The asymmetric defect/ percentage of asymmetry (Δ) in the structure, incorporated by means of a position-wise shift of Ag nanodisc exhibits pivotal results in performance parameters, including intra channel sensitivity (S
intra), channel separation factor (CH
factor
), figure of merit (FOM) and Q-factor. The pairs of sensing windows of the hybrid structure show a geometric symmetry along the x and −x direction and an asymmetry along its perpendicular (y and −y). Among the symmetric and asymmetric channels, spatially resolved plasmonic modes of asymmetric channels facilitate the multi quantification of analytes in a single stimulation, whereas symmetric ones confirm the presence of the different analytes in the given specimen. With the sensor function flexible to light incidence direction, the matrix system can be effectively employed across medical diagnostics and healthcare monitoring.
Biological miniature temperature sensor based on monodisperse microsphere lasers fabricated by soft microfluidic technology
Authors: Nguyen Toan Van , Nguyen Trung Duc , Mai Hanh Hong , Pham Nhat Van , Ta Van Duong , Nguyen Tien-Anh 
Published: July 2022

Abstract
Microsphere biolasers employing biological materials as their cavity matrix have attracted tremendous research attention due to their potential for bio-integration, cell-tracking and biosensing. Several techniques have been applied for fabricating microsphere biolasers such as emulsion and vacuum freeze-drying but the current technology generally can not control the output size of the laser and therefore hinder them from many applications. In this work, we demonstrate that a low-cost microfluidic device can be very effective in fabricating nearly monodisperse dye-doped protein microspheres with up to 70% of them having the same size. Under optical pumping, these microspheres emit lasing emission with a lasing threshold of ∼1 µJ and a quality factor of ∼2.5 × 103. The lasing mechanism is ascribed to whispering gallery mode. Furthermore, the obtained microlasers can be employed for temperature sensing based on the wavelength shift of lasing mode with increasing temperature. The sensor sensitivity in the measured range of 25 °C–50 °C is about 0.47 nm/°C. More interestingly, microlasers of the same size exhibit a very similar sensing performance which confirm their high reproducibility and reliability. Owing to the biocompatibility and small size, these miniature laser-based sensors can be implantable in skins and tissues for biological studies and medical diagnostic.
Non-Arrhenius behaviour of nickel self-diffusion in liquid Ni77Si23
Authors: Demmel F 
Published: July 2022

Abstract
Nickel self-diffusion was measured for a Ni77Si23 alloy in the liquid state over a temperature range of about 400 K through quasielastic neutron scattering. At the two lowest temperature points the derived diffusion coefficients deviate from a high-temperature Arrhenius-type behaviour and indicate a change in dynamics above the liquidus temperature. A fit with a power-law temperature dependence as predicted by the mode coupling theory for the liquid to glass transition can describe the diffusion coefficients quite well over the whole measured temperature range. The obtained results agree with predictions from a classical molecular dynamics (MD)-simulation, which evidenced an increasing glass forming ability with increasing silicon content. A crossover to a super-Arrhenius behaviour was reported for metallic glass formers above the liquidus temperature and the here investigated NiSi alloy demonstrates the same signature.