bluuebunny/crossref_metadata_2025_split huggingface dataset:
A barcoding pipeline for mosquito surveillance in Nepal, a biodiverse dengue-endemic country
Authors: Hartke Juliane , Reuss Friederike , Kramer Isabelle Marie , Magdeburg Axel , Deblauwe Isra , Tuladhar Reshma , Gautam Ishan , Dhimal Meghnath , Müller Ruth 
Published: April 2022

AbstractBackgroundVector-borne diseases are on the rise on a global scale, which is anticipated to further accelerate because of anthropogenic climate change. Resource-limited regions are especially hard hit by this increment with the currently implemented surveillance programs being inadequate for the observed expansion of potential vector species. Cost-effective methods that can be easily implemented in resource-limited settings, e.g. under field conditions, are thus urgently needed to function as an early warning system for vector-borne disease epidemics. Our aim was to enhance entomological capacity in Nepal, a country with endemicity of numerous vector-borne diseases and with frequent outbreaks of dengue fever.MethodsWe used a field barcoding pipeline based on DNA nanopore sequencing (Oxford Nanopore Technologies) and verified its use for different mosquito life stages and storage methods. We furthermore hosted an online workshop to facilitate knowledge transfer to Nepalese scientific experts from different disciplines.ResultsThe use of the barcoding pipeline could be verified for adult mosquitos and eggs, as well as for homogenized samples, dried specimens, samples that were stored in ethanol and frozen tissue. The transfer of knowledge was successful, as reflected by feedback from the participants and their wish to implement the method.ConclusionsCost effective strategies are urgently needed to assess the likelihood of disease outbreaks. We were able to show that field sequencing provides a solution that is cost-effective, undemanding in its implementation and easy to learn. The knowledge transfer to Nepalese scientific experts from different disciplines provides an opportunity for sustainable implementation of low-cost portable sequencing solutions in Nepal.Graphical Abstract
Capecitabine-induced severe diabetes and hypokalemia: a case report
Authors: Yang Qiaoling , Chen Chuping , Ran Jianmin 
Published: April 2022

Abstract
Background
Capecitabine is widely used in chemotherapy for breast, colorectal, and gastric cancers. The frequent adverse reactions of capecitabine mainly include gastrointestinal side effects, anemia, and cardiovascular toxicity. Here, we report a rare case of severe hyperglycemia and hypokalemia during long-term treatment with capecitabine.

Case presentation
A 48-year-old Chinese female was hospitalized with the complaint of breathlessness and weakness after activity, for 1 month. Her past history is significant for a diagnosis of right-sided breast cancer 7 years ago. She underwent right mastectomy, following which capecitabine was started 1.5 years prior to the current admission as part of her primary treatment at the discovery of systemic osseous metastasis. Her fasting plasma glucose and hemoglobin A1c levels were quite normal 7 months ago but increased to 15.3 mmol/L and 11.2%, respectively, at the present admission. Her serum potassium level was as low as 2.5 mmol/L. Plasma autoantibodies related to islets and insulin were all negative. Capecitabine was discontinued, and an insulin pump and potassium supplement were given after admission. Her blood sugar and potassium levels returned to their normal ranges soon. Self-injection of insulin was withdrawn completely at 2 months after discharge, and no oral hypoglycemic agents were added. Her plasma glucose and electrolyte levels were at normal levels at her 1-year follow-up.

Conclusion
Glucose intolerance and hypokalemia may be rare but serious adverse effects during long-term chemotherapy with capecitabine.
Mapping of major tectonic lineaments across Cameroon using potential field data
Authors: Cheunteu Fantah Cyrille Armel , Mezoue Cyrille Adiang , Mouzong Marcelin Pemi , Tokam Kamga Alain Pierre , Nouayou Robert , Nguiya Severin 
Published: April 2022

AbstractThe cartography of lineaments across a territory can be optimized using geophysical potential field data. In this study, land gravity and EMAG2 (Earth Magnetic Anomaly Grid) data were simultaneously used to identify and characterize the major lineaments that spread across Cameroon. The data were filtered using a multi-scale approach including horizontal and vertical gradient analyses. The Euler Deconvolution method was later applied to the filtered data to estimate the extension and depth of the identified lineaments. Results show that the main lineaments across Cameroon are laterally extended with a dominant N45°E orientation. Some of these lineaments correlated well with the geographical location of some known major tectonic structures found across the country. The depth of these lineaments varies between 1 and 35 km. Some of the identified faults are still active as their location correlated with the location of some recent earthquakes that occurred in Cameroon. This work, therefore, highlights some hidden tectonic features which knowledge generally precedes exploration for subsurface resources.
Graphical Abstract
Characteristics of the deep sea tsunami excited offshore Japan due to the air wave from the 2022 Tonga eruption
Authors: Tanioka Yuichiro , Yamanaka Yusuke , Nakagaki Tatsuya 
Published: April 2022

AbstractA large eruption of the Hunga Tonga-Hunga Haʻapai volcano in Tonga on January 15, 2022 generated air–sea coupled tsunamis observed at the ocean-bottom pressure sensor network along the Japan Trench (S-net) in Japan. Initial tsunamis from the 2022 Tonga eruption, detected by 106 ocean-bottom pressure sensors, were well modeled by an air–sea coupled tsunami simulation, with a simple atmospheric pressure pulse as sine function, having a half-wavelength of 300 km and a peak amplitude of 2 hPa. A one-dimensional air–sea coupled tsunami simulation having a simple bathymetry shows that an input atmospheric pressure pulse with a short half-wavelength of 50 km, which is shorter than the length of the ocean bottom slopes, caused an amplitude increase via the Proudman resonance effect near the deep trench. The wavefront distortion due to the separation of the air–sea coupled wave propagating with a speed of 312 m/s and tsunami propagating with that of $$\sqrt{gd}$$

gd

, where g is gravity acceleration and d is the ocean depth, is also significant near the shore. In contrast, these effects are not significant for the half-wavelength of the input atmospheric pressure pulse of 300 km. These results indicate that the air–sea coupled tsunami propagating through the trench is sensitive to the wavelength of an atmospheric pressure pulse.
Graphical Abstract
A rare case of pseudoaneurysmal hemorrhage, necrotizing fasciitis, and costochondritis after pancreaticoduodenectomy
Authors: Li Lulu , Abe Kyohei , Okamoto Tomoyoshi , Matsumoto Michinori , Futagawa Yasuro , Kanehira Masaru , Ikegami Toru 
Published: April 2022

Abstract
Background
Necrotizing fasciitis after pancreaticoduodenectomy (PD) has never been reported. We experienced a case of necrotizing fasciitis caused by pseudoaneurysmal hemorrhage after PD.

Case presentation
A 72-year-old male was diagnosed with cholangiocarcinoma and underwent PD. Bile leakage was detected postoperatively, conservatively resolved, and the patient was discharged on the 36th day after surgery. On the 42nd day after surgery, a pseudoaneurysm of the gastroduodenal artery ruptured. Transcatheter arterial embolization was performed for hemostasis: however, a large intra-abdominal abscess caused by an infected hematoma was recognized. On the 57th day after surgery, the patient developed necrotizing fasciitis. He underwent debridement with skin reconstruction using a latissimus dorsi flap and skin transplantation. Costochondritis and liver metastasis were detected on the 267th day after surgery. Infection was controlled by rib cartilage resection, debridement, and negative pressure wound therapy. Chemotherapy involving gemcitabine and cisplatin was initiated on the 460th day after the initial surgery with a partial response (PR) and was continued for more than one year.

Conclusions
We herein reported a rare case of necrotizing fasciitis following hematoma infection after PD that was treated using multidisciplinary therapy with PR following chemotherapy.
Terrestrial medium and large-sized mammalian species diversity in Michole Community Protected Forest, southern Ethiopia
Authors: Agebo Amanuel , Tekalign Wondimagegnehu 
Published: April 2022

AbstractThe study on medium and large-sized mammalian species' diversity and distribution is important for conservation efforts in the different protected areas of Ethiopia. The present study was intended to investigate the species diversity of medium and large-sized mammalian fauna between October 2019 and July 2020 in Michole Community Protected Forest, southern Ethiopia. The study was conducted by stratification of the study area into three habitat types: riverine forest (3.37 km2), woodland (4.14 km2), and grassland with scattered trees (2.33 km2) based on the vegetation cover. A diurnal transect survey method was implemented to record the mammalian species diversity. A total of 18 representative sample transect lines (six in riverine forest, four in grassland with scattered trees, and eight in woodland habitats) that varied in length and width were used. A total of 17 species of medium and large-sized mammalian species were identified and recorded in the study area. As a result, the orders Carnivora and Primates have the greatest abundance, while the order Lagomorpha has the least. Anubis baboon (Papio anubis) was the most abundant species (15.14%), followed by Spotted hyena (Crocuta crocuta) (12.98%), Crested porcupine (Hystrix cristata) (12.51%), Vervet monkey (Chlorocebus aethiops) (10.35%), Common duiker (Sylvicapra grimmia) (8.80%), and Giant root-rat (Tachyoryctes macrocephalus) (8.65%). The distributions of mammals among the three habitat types were comparable. The riverine forest harbored the highest mammalian diversity index (H′ = 2.35) followed by the woodland (H′ = 2.32), and the grassland with scattered trees (H′ = 2.30), respectively. The greatest species similarity was recorded in woodland (0.902). The study area harbors considerable mammalian species that are threatened by interacting anthropogenic factors. So, urgent conservation measures by concerned sectors are needed to safeguard these animals and their habitat.
Molecular docking assisted exploration on solubilization of poorly soluble drug remdesivir in sulfobutyl ether-tycyclodextrin
Authors: Zhang Yumeng , Zhao Zhouming , Wang Kai , Lyu Kangjie , Yao Cai , Li Lin , Shen Xia , Liu Tengfei , Guo Xiaodi , Li Haiyan , Wang Wenshou , Lai Tsai-Ta 
Published: April 2022

Abstract
Objective
To study structure-specific solubilization effect of Sulfobutyl ether-β-cyclodextrin (SBE-β-CD) on Remdesivir (RDV) and to understand the experimental clathration with the aid of quantum mechanics (QM), molecular docking and molecular dynamics (MD) calculations.

Methods
The experiment was carried out by phase solubility method at various pH and temperatures, while the concentration of Remdesivir in the solution was determined by HPLC. The complexation mechanism and the pH dependence of drug loading were investigated following a novel procedure combining QM, MD and molecular docking, based on accurate pKa predictions.

Results
The phase solubility and solubilization effect of RDV in SBE-β-CD were explored kinetically and thermodynamically for each assessed condition. An optimal drug / SBE-β-CD feeding molar ratio was determined stoichiometrically for RDV solubility in pH1.7 solution. The supersaturated solubility was examined over time after pH of the solution was adjusted from 1.7 to 3.5. A possible hypothesis was raised to elucidate the experimentally observed stabilization of supersaturation based on the proposed RDV Cation A /SBE-β-CD pocket conformations.

Conclusion
The computational explorations conformed to the experimentally determined phase solubilization and well elucidated the mechanism of macroscopic clathration between RDV and SBE-β-CD from the perspective of microscopic molecular calculations.

Graphical Abstract
Antibiotic prescription rationality and associated in-patient treatment outcomes in children under-five with severe pneumonia at Bwizibwera health center IV, Mbarara District, South-Western Uganda
Authors: Abeja Christine Joy , Niyonzima Vallence , Byagamy John Paul , Obua Celestino 
Published: April 2022

Abstract
Background
Pneumonia is a major cause of morbidity and mortality in children under five. Antibiotic treatment must be started immediately in children with pneumonia. The irrational use of antibiotics may increase morbidity and mortality in children with pneumonia. Pneumonia accounted for approximately 16% of the 5.6 million under-five deaths word wide in 2016. In Uganda, it kills approximately 2,400 children per year. Early diagnosis and appropriate case management with rational use of antibiotics remain the most effective intervention to reduce pneumonia-related mortality. This study aimed at determining antibiotic prescription rationality and associated in-patient treatment outcomes in children aged 2–59 months with severe community-acquired pneumonia at Bwizibwera Health Centre IV from 1st May 2018 to 30th April 2019.

Methods
We conducted a retrospective cohort study design; data were collected from in-patient records of all children aged 2–59 months with severe community-acquired pneumonia who met the eligibility criteria for a period of one year. Data abstraction template was used for data collection. Health care records of children aged 2–59 months who had other co-morbidities and were on medication that could influence or impact on in-patient treatment outcomes from 1st May 2018 to 30th April 2019 were excluded. Data was entered and analyzed using Epi-info v 7.2 and STATA v 13.0 respectively, Descriptive statistics were reported and Chi-square test was used to compare the proportions.

Results
Of the total records of children retrieved and screened (N = 847), 229 prescription records of children fulfilled inclusion criteria, 57 (24.9%) had rational prescriptions with good outcomes and 172 (75.1%) had irrational prescriptions with 10 (4.4%) having unfavorable outcomes. The majority (73.7%) of those who received rational prescription were on treatment with a combination of benzyl penicillin plus gentamycin while (26.3%) were on ampicillin plus gentamycin. The majority (32.4%) of patients with good treatment outcomes were aged 6 – 11 months. This age category also doubled as the group that experienced the highest percentage (40.0%) of unfavorable outcomes. There were no statistically significant associations between patient characteristics and treatment outcomes.

Conclusion
In conclusion, the majority of children had irrational antibiotic prescriptions and 40 percent of children aged 6–11 Months had unfavorable treatment outcomes with 20 percent death. This study also found out that majority of antibiotic prescription among children under five was irrational and it’s against Uganda clinical guideline for treatment of severe pneumonia among children under five.
Circulating CTRP5 in rheumatoid arthritis: an exploratory biomarker study
Authors: Taherian Marjan , Almasi Simin , Mehdizadeh Saber , Fazeli Banafshe , Kalantari Mahsa , Bayati Paria , Pashangzadeh Salar , Mojtabavi Nazanin 
Published: April 2022

Abstract
Background
Rheumatoid arthritis (RA) is an inflammatory disease that is characterized by the overproduction of cytokines. Among the newly discovered cytokines are the adipokines which are primarily produced by and released from the adipose tissue and some immune cells, as well as synovial cells. they are involved in various immune responses and inflammatory processes. However, there are controversial data regarding the pro-inflammatory or anti-inflammatory effects of adipokines in different conditions. C1q/TNF-related protein 5 (CTRP5) is a newly identified adipokine and adiponectin paralogous protein, which has been shown to be correlated with inflammatory diseases. Accordingly, the present study was designed to investigate the serum levels of CTRP5 in RA patients and evaluate any possible alterations in comparison to healthy individuals.

Methods
Serum CTRP-5 levels were measured in 46 patients and 22 healthy controls by ELISA. The demographic, laboratory, and clinical features of the patients were also evaluated in order to find any correlations.

Results
Serum levels of CTRP-5 were significantly (p < 0.0001) higher in patients with RA (14.88 ± 25.55) compared to healthy controls (4.262 ± 2.374). There was a significant correlation between serum CTRP-5 levels and triglyceride (TG) (r: − 0.3010, p: 0.0498), as well as erythrocyte sedimentation rate (ESR) (r: 0.3139, p: 0.0457), C-reactive protein (CRP) (r: 0.5140, p: 0.0008), and the number of white blood cells (WBC) (r: 0.3380, p: 0.0307), which are considered as the markers indicating the extent of inflammation. Moreover, CTRP-5 was found to be correlated with interstitial lung disease (ILD) (r: 0.3416, p: 0.0385), a comorbidity associated with RA disease.

Conclusion
This study demonstrated the increased level of circulating CTRP-5 in RA patients, which correlated with some inflammation-associated parameters and RA-associated comorbidities. Our observations suggest CTRP-5 as a putative inflammatory biomarker in RA, which may be useful besides the other disease-related markers.
Efficacy of some entomopathogens against Ephestia cautella (Walker) (Lepidoptera: Pyralidae) in stored date fruits
Authors: El Shafei Wael Kamal Mohamed , Mahmoud Rania Hassan , Mohamed Sahar Sayed Ali 
Published: April 2022

Abstract
Background
Ephestia cautella (Walker) (Lepidoptera:Pyralidae) is one of the most economically important date fruits insect pests, which causes major losses in quantity and quality of the date yield. The present study aimed to evaluate 3 of the entomopathogens: Beauveria bassiana (Basonym 1836), Metarhizium anisopliae (Metchnikoff 1879), and Bacillus thuringiensis (Berliner 1915) var. kurstaki individually and mixed with each other against E. cautella in stored date fruits.

Results
Four concentrations from spores' suspension of each entomopathogen were sprayed on 50 eggs of E. cautella (24:48 h. old) (for fungal pathogens) and 30 2nd instar larvae of E cautella in glass jars. Pathogenicity was evaluated at different time intervals post treatments 3, 5,7and 14 days. Obtained results showed that mortality percentages of E cautella stages increased by increasing the tested entomopathogen concentrations and increasing of the exposure time. Results indicated that the reduction percentages of E. cautella eggs hatchability after separately treated at the concentrations (3.0 × 105, 3.0 × 106, 3.0 × 107 and 3.0 × 108 spores/ml) were (27.50, 39.17, 48.33 and 62.50%) for B. bassiana, (35.83, 44.17, 50.83 and 69.17%) for M. anisopliae, respectively. After14 days of treatment, the recorded larval mortalities were (49, 62, 77, and 81%) for B. bassiana and (60, 66, 78, and 89%) for M. anisopliae at concentrations (3.0 × 105, 3.0 × 106, 3.0 × 107and 3.0 × 108 spores/ml), respectively. In case of treating E. cautella larvae with B. thuringiensis, the mortality percentage was (44, 52, 63, and 72%) at concentrations (2.0 × 108, 2.0 × 109, 2.0 × 1010 and 2.0 × 1011 spores/ml), respectively, after14 days of exposure. E. cautella larvae were more susceptible to B. bassiana and M. anisopliae than the eggs. M. anisopliae was more effective than B. bassiana. The combination of the entomopathogens LC50 (B. bassiana + M. anisopliae, B. bassiana + B. thuringiensis, M. anisopliae + B. thuringiensis and B. bassiana + M. anisopliae + B. thuringiensis) caused E. cautella larval mortality percentages of 67.00, 73.33, 63.33 and 86.29%, respectively, 14 days after exposure. The combination of the 3 tested entomopathogens (B. bassiana + M. anisopliae + B. thuringiensis) increased their efficacy for controlling E. cautella.

Conclusions
The combination of the tested entomopathogens: B. bassiana, M. anisopliae and B. thuringiensis could be recommended for controlling E. cautella stages in stored date fruits.
Short Term Solar Irradiation Forecasting using CEEMDAN Decomposition Based BiLSTM Model Optimized by Genetic Algorithm Approach
Authors: Gupta Anuj , Gupta Kapil , Saroha Sumit 
Published: April 2022

An accurate short-term solar irradiation forecasting is requiredregarding smart grid stability and to conduct bilateral contract negotiations between suppliers and customers. Traditional machine learning models are unable to acquire and to rectify nonlinear properties from solar datasets, which not only complicate model formation but also lower prediction accuracy. The present research paper develops a deep learningbased architecture with a predictive analytic technique to address these difficulties. Using a sophisticated signal decomposition technique, the original solar irradiation sequences are decomposed into multiple intrinsic mode functions to build a prospective feature set. Then, using an iteration strategy, a potential range of frequency associated to the deep learning model is generated. This method is developed utilizing a linked algorithm and a deep learning network. In comparison with conventional models, the suggested model utilizes sequences generated through preprocessing methods, significantly improving prediction accuracywhen confronted with a high resolution dataset created from a big dataset.On the other hand, the chosen dataset not only performs a massive data reduction, but also improves forecasting accuracy by up to 20.74 percent across a range of evaluation measures. The proposed model achieves lowest annual average RMSE (1.45W/m2), MAPE (2.23%) and MAE (1.34W/m2) among the other developed models for 1-hr ahead solar GHI, respectively, whereas forecast-skill obtained by the proposed model is 59% with respect to benchmark model. As a result, the proposed method might be used to predict short-term solar irradiation with greater accuracy using a solar dataset
Цифровизация российской средней школы: отдача и факторы риска
Authors: Попов Дмитрий Сергеевич , Стрельникова Анна Владимировна , Григорьева Екатерина Александровна 
Published: April 2022

Цифровизация школ в восприятии людей зачастую связана лишь с техническим переоборудованием: с приобретением новых компьютерных средств или разработкой общешкольных онлайн-программных продуктов («порталов»). Однако техническая трансформация школы последних десятилетий предполагает весьма глубокие и серьезные изменения для профессии учителя и социальных отношений в школе. В статье на основе международных сравнительные данных программы PISA показано, что существующие цифровые школьные практики в европейских странах и в России не приводят к повышению измеренных компетенций учащихся в разных предметных областях. В литературе высказывается гипотеза, что расширенный доступ к цифровым устройствам (включая ноутбуки, планшеты, мобильные телефоны и т. д.) сам по себе не ведет к развитию и совершенствованию образовательной практики. В статье предложены результаты исследования российских учителей, направленного на изучение качественных характеристик цифровых изменений в школах. В исследовании выявляется отношение учителей к процессу цифровизации, оцениваются их существующие профессиональные практики, показаны опасения и ожидания от возможной институциональной трансформации и трансформации профессии учителя. Обнаружено, что цифровизация в российской школе направлена на поддержание и воспроизводство прежних доцифровых практик, а не на развитие новых.