bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enabling self-shape estimation of composite structures using distributed microfabricated strain gauge networks
Authors: Chen Xiyuan , Nasrollahi Amir , Ransom Elliot , Topac Tanay , Chang Fu-Kuo 
Published: November 2022

In this study, smart multifunctional composites (SMC) were developed to enable state estimation of structures in terms of the deformations at distributed locations due to applied loads and temperature gradients. The SMC was composed of a carbon fiber-reinforced polymer (CFRP) composite plate and an embedded microfabricated sensor network of densely distributed strain gauges. The microfabricated sensor network, with serpentine signal wires connecting the sensing elements, was manufactured on a 100 mm diameter silicon wafer using integrated circuit batch processing techniques. The robustness of the SMC was investigated and verified through shape estimation under mechanical loads and temperature gradients applied to the SMC. The mechanical load was applied to the SMC with fixed boundaries on four edges. The temperature gradient was applied to the SMC with simple supports on the four corners of the SMC plate by applying a uniform temperature on one side while controlling the temperature of the other side close to the room temperature. The results show that the SMC provides the shape of the deformed structure under loads with high resolution. Moreover, a numerical analysis of the SMC implemented in ABAQUS demonstrates a close correlation between the estimated deformed shape and the simulated structure allowing the potential establishment of a digital twin. The SMC can be customized based on different requirements and applications by selecting the type, number, and locations of the sensors. The shape and state of the structure obtained from the SMC during operation can be used for online control, autonomy, decision-making, and maintenance.
Enhanced mechanical properties and improving wetting ability of polypropylene/cassava pulp composites
Authors: Prakymoramas Natcha , Keeratipinit Kawin , Sirirutbunkajal Pakjira , Issaraseree Yolada , Keawket Sanya , Rojsatean Jareenuch , Jaruwongrungsee Kata , Hararak Bongkot , Rungseesantivanon Wuttipong , Winotapun Charinee 
Published: November 2022

Natural cassava pulp was selected as a bio-based reinforcement in plastic polymer composites to enhance mechanical and wetting properties as an eco-friendly product. This study developed reinforced polypropylene (PP) composites with cassava pulp (CP) to improve mechanical properties and wetting ability. The PP/CP specimens were fabricated via twin screw extrusion and injection molding. Tensile and flexural testing were performed using a universal testing machine, with wetting properties characterized by a contact angle goniometer. Incorporation of 10 wt% cassava pulp showed enhanced tensile strength (4.85%), Young’s modulus (14.38%) and flexural modulus (23.30%) compared with neat polypropylene, indicating higher stiffness of natural fiber-filled composites. Micropatterns were formed on the composite surfaces using the hot embossing technique. A superhydrophobic surface was achieved by designing micropattern geometry. Water contact angle of micropatterned neat polypropylene and polypropylene/cassava pulp composites increased compared to material with no pattern. Micropatterns on PP/CP composite surfaces can be used to develop new functional materials with high mechanical and superhydrophobic properties.
Increase in SARS-CoV-2 RBD-Specific IgA and IgG Antibodies in Human Milk From Lactating Women Following the COVID-19 Booster Vaccination
Authors: Henle Andrea M. 
Published: November 2022

Background: The United States Centers for Disease Control and Prevention recommended a third dose or booster of the Pfizer-BioNTech Comirnaty (BNT162b2) COVID-19 mRNA vaccine in September 2021 for high-risk individuals. Pregnant and high-risk lactating women were encouraged to receive the booster to obtain potential prolonged protection for themselves and their infants. Research Aim: To investigate the ability of the booster vaccine to increase IgA and IgG antibodies specific to the receptor-binding domain of the SARS-CoV-2 spike protein in human milk compared to levels pre-booster. Methods: This was a prospective one-group study with a pretest-posttest design. Six of 12 participants were recruited prospectively. Participants were instructed to collect ≥ 2 ounces of milk in the morning at 30 days and 1-day pre-booster, and 7, 14, 21, 30, 45, and 60 days post-booster. Levels of IgA and IgG antibodies specific to the receptor-binding domain of the SARS-CoV-2 spike protein were quantified in human milk via an ELISA assay. Results: We found a significant increase in anti-receptor-binding domain-specific IgA and IgG antibodies in human milk 1–2 weeks after the Pfizer-BioNTech booster and at the study endpoint (45- and 60-days post-booster) Conclusions: This suggests that the booster vaccination enhances SARS-CoV-2 specific immunity in human milk, which may be protective for infants.
Car and train platoon simulations
Authors: Wu Qing , Ge Xiaohua , Cole Colin , Spiryagin Maksym 
Published: November 2022

Detailed simulations of car and train platoons are critical steps towards successful implementations of the platooning technologies. This paper developed a simulation method that can be used for both car and train platoon simulations. The method includes three main parts: (1) a scalable adaptive longitudinal space controller, (2) 2D multibody dynamics simulations that consider wheel-rail contact (Polach model), tyre-road contact (Magic Formula), suspensions and in-train forces, and (3) a scalable parallel computing method that processes the dynamics simulation of each individual vehicle (one car or one carriage) by using one independent computer core. Two case studies were conducted to simulate a 6-car platoon and a 3-train platoon on real-world road and track. The maximum space errors for the car platoon and the train platoon results were about 0.32 and 0.23 m, respectively. When the platoons were running at a steady speed, space errors were well controlled within ±0.05 m for both car and train platoons. Example dynamics results were presented including wheel-rail contact forces, tyre-road contact forces, and carbody vibrations. This information can be used to conduct a wide range of related studies such as passenger ride comfort and system damage assessments.
HLA-DRB1*1501 influences long-term disability progression and tissue damage on MRI in relapse-onset multiple sclerosis
Authors: Brownlee Wallace J , Tur Carmen , Manole Andreea , Eshaghi Arman , Prados Ferran , Miszkiel Katherine A , Wheeler-Kingshott Claudia AM Gandini , Houlden Henry , Ciccarelli Olga 
Published: November 2022

Background: Whether genetic factors influence the long-term course of multiple sclerosis (MS) is unresolved. Objective: To determine the influence of HLA-DRB1*1501 on long-term disease course in a homogeneous cohort of clinically isolated syndrome (CIS) patients. Methods: One hundred seven patients underwent clinical and MRI assessment at the time of CIS and after 1, 3, 5 and 15 years. HLA-DRB1*1501 status was determined using Sanger sequencing and tagging of the rs3135388 polymorphism. Linear/Poisson mixed-effects models were used to investigate rates of change in EDSS and MRI measures based on HLA-DRB1*1501 status. Results: HLA-DRB1*1501 -positive ( n = 52) patients showed a faster rate of disability worsening compared with the HLA-DRB1*1501 -negative ( n = 55) patients (annualised change in EDSS 0.14/year vs. 0.08/year, p < 0.025), and a greater annualised change in T2 lesion volume (adjusted difference 0.45 mL/year, p < 0.025), a higher number of gadolinium-enhancing lesions, and a faster rate of brain (adjusted difference −0.12%/year, p < 0.05) and spinal cord atrophy (adjusted difference −0.22 mm2/year, p < 0.05). Interpretation: These findings provide evidence that the HLA-DRB1*1501 allele plays a role in MS severity, as measured by long-term disability worsening and a greater extent of inflammatory disease activity and tissue loss. HLA-DRB1*1501 may provide useful information when considering prognosis and treatment decisions in early relapse-onset MS.
Perinatal Tissue–Derived Allografts and Stromal Cells for the Treatment of Knee Osteoarthritis: A Review of Preclinical and Clinical Evidence
Authors: Sawvell Emily , Wright Noah , Ode Gabriella , Mercuri Jeremy 
Published: November 2022

Objective The use of perinatal-derived tissues and mesenchymal stromal cells (MSCs) as alternative treatment options to corticosteroid and hyaluronic acid injections has been gaining popularity. However, their ability to attenuate osteoarthritic (OA) symptoms while also slowing the progression of the disease remains controversial. Thus, the objective of this article is to summarize the results from both preclinical and clinical studies evaluating the efficacy of perinatal-derived tissue allografts and MSCs for the treatment of OA. Design A comprehensive literature search was conducted on databases including Pubmed, ScienceDirect, and Google Scholar beginning in March 2020 for both preclinical and clinical studies evaluating perinatal-derived tissues and MSCs in OA. Eighteen studies met the inclusion criteria and were used for this review. Results Both animal models and early human clinical trials demonstrated that perinatal tissues could reduce joint inflammation and pain as well as improve range of motion and function in OA. Perinatal tissue–derived MSCs in animal studies have shown the potential to support chondrocyte proliferation while also decreasing inflammatory gene and protein expression. Limited clinical results suggest perinatal tissue–derived MSC sources may also be a viable alternative or adjunct to hyaluronic acid in reducing pain and symptoms in an arthritic joint. Conclusions Perinatal tissue–derived allografts and MSCs have promise as potential therapeutics for mitigating OA progression. However, further research is warranted to fully define the therapeutic mechanism(s) of action and safety of these biological therapies.
Early activation of artificial urinary sphincter for stress incontinence is safe: A pilot study
Authors: David Rowan V , Kahokehr Arman A 
Published: November 2022

Background: Artificial urinary sphincter (AUS) activation is usually deferred until 6 weeks following insertion. However, this timeframe for activation is based on traditional dogma. This study aims to assess the feasibility, efficacy and safety of earlier activation of AUS. Methods: A prospective database was established on consecutive patients undergoing AUS implantation (AMS-800 Boston Scientific) from March 2019 to March 2022 by a single fellowship-trained urologist. Early activation was defined as <30 days from the date of implantation. Results: Twenty-one patients were included in the study with a median follow-up of 34 (range: 3–96) months. The most common indication for AUS insertion was post-prostatectomy stress urinary incontinence ( n = 19, 90%). All 21 patients had their AUS successfully activated and used before 30 days, with a median of 14 (range: 9–28) days. Median (range) pre-operative continence pad numbers were 3 (2–6) and 0 (0–1) at 4 weeks post-operatively. Median (range) pad weight per day was 600 g (190–1310 g) pre-operatively and 6 g (0–6 g) at 4 weeks post-operatively. There were no adverse events associated with early activation. Conclusion: To our knowledge, this is the first description of the early activation of the AMS-800 AUS device. Our preliminary experience indicates early activation is safe and acceptable for patients. Level of evidence: II
Training Background and Characteristics of NFL, MLB, and NBA Team Physicians
Authors: Young Matthew W. , Plummer Hillary A. , Fleisig Glenn S. 
Published: November 2022

Background: An analysis of the demographics and training of head team physicians (HTPs) in professional sports would be valuable for evaluating training programs and as a resource for aspirant HTPs. Purpose: To outline common characteristics among professional sport HTPs. Study Design: Cross-sectional study. Methods: In June 2021, publicly available directories and news articles were used to identify the head orthopaedic HTPs and primary care HTPs for every team in Major League Baseball (MLB), the National Basketball Association (NBA), and the National Football League (NFL). Data regarding HTP characteristics were collected via internet-based sources. Age, sex, years from fellowship completion to current team role, and years in current team role were compared across sports with chi-square analyses and analyses of variance; comparisons between orthopaedic and primary care HTPs were performed with Fisher exact tests and Student t tests. The most frequently attended residency and fellowship training programs were also calculated. The productivity of fellowship programs was calculated as the number of current HTPs from that institution divided by the number of fellowship positions currently offered. Results: We identified 181 HTPs: 171 (94%) men and 10 (6%) women. The mean age was 55.4 years (range, 33-79 years); the mean time from fellowship training completion to first year in current team role was 9.8 years (range, 0-29 years); and the mean time spent in current team role was 14.1 years (range, 0-39 years). There were 94 orthopaedic HTPs and 87 primary care HTPs. The rate of fellowship training was significantly higher in orthopaedic HTPs (95%) than in primary care HTPs (67%; P < .001). The fellowship programs that produced the largest number of current HTPs were the Hospital for Special Surgery (n = 16; productivity = 2.3), the American Sports Medicine Institute (11; 1.8), and the Kerlan-Jobe Orthopaedic Clinic (11; 1.2). The years from fellowship to HTP varied significantly by sport: 7.2 for MLB, 10.0 for the NFL, and 11.7 for the NBA ( P = .048). Conclusion: Almost all orthopaedic HTPs were fellowship trained, as compared with two-thirds of primary care HTPs. Of the 94 orthopaedic HTPs, 62% were trained at 6 specific fellowship programs. Men accounted for a majority of HTPs.
Comparison of Foot Center Axis and Ankle Rotation using Weight-Bearing CT
Authors: Rascoe Alexander S. , Aitchison Alexandra H. , Ridenour Ryan M. , Wang Miqi , Adams Samuel B. 
Published: November 2022

Category: Ankle; Ankle Arthritis Introduction/Purpose: Even as its popularity increases, there remain many unanswered questions regarding total ankle arthroplasty. One debate considers how best to restore proper rotation of the talar component relative to native, non- osteoarthritic anatomy. At present, two common schools of thought are to parallel the talar component rotation with the medial gutter line or to choose a line that bisects the gutters. These axis' are then considered with respect to a chosen foot axis, often defined by the second metatarsal or second toe clinically. The present study sought to define the foot center axis relative to the ankle on weight-bearing CT in patients without ankle osteoarthritis to inform talar component positioning in total ankle arthroplasty. Methods: Following IRB approval, charts were reviewed to identify patients without ankle osteoarthritis, trauma or other deformity who received a weightbearing CT scan. A pilot group of n=34 patients were included for a total of n=50 limbs. Average age was 50.3 +/- 7 and there were = 54% female patients. All measurements were made on MPR (multiplanar reformation) axial reconstructions. Cobb angle measurements between the anatomic foot center, the second, the fourth metatarsal and the gutter bisector or medial gutter line were recorded. Statistical analysis was performed by IBM SPSS Statistics for Windows, Version 27.0. Armonk, NY. Results: The mean gutter bisector angle was 5.7 deg +/- 2.0. The mean cobb angle between the anatomic foot center and the medial gutter line was 6.1 deg +/- 4.4 and between the anatomic foot center and gutter bisector was 6.3 deg +/- 4.8, there was no statistical difference between measurements (p=0.62, Table 1). The mean cobb angle between the second metatarsal and the gutter bisector was 9.9 deg +/- 6.8, whereas the mean cobb angle between the fourth metatarsal and the gutter bisector was 7.5 deg +/- 5.2, which was not statistically significant (p=0.053). There was no statistical difference between mean cobb angle measurements between the anatomic foot center and the gutter bisector and the fourth metatarsal and the gutter bisector (p=0.243), but there was statistical difference between mean cobb angle measurements of the second metatarsal and the gutter bisector and the anatomic foot center and the gutter bisector (p=0.003). Conclusion: The axial alignment of the foot center axis relative to the ankle in patients without deformity or osteoarthritis is most collinear with the medial gutter line. In general, the axial alignment of the ankle joint relative to the foot in patients without osteoarthritis tends towards <10 degrees of difference on weight-bearing CT, regardless of method chosen. Due to both the consistency of measure and reproducibility of measure on pre-operative weight-bearing CT, the anatomic foot center may be a useful guide for establishing intra-operative foot orientation when performing total ankle arthroplasty.
Indication and Consideration of Minimally Invasive Bosh Akin (MIBA) for Salvage in Recurrence of Hallux Valgus
Authors: Redlich Alex , Ortiz Cristian A. , Chaparro Felipe R. , Mombello Franco L. 
Published: November 2022

Category: Bunion Introduction/Purpose: Hallux valgus recurrence is a common complication to consider, depending on the different series it has an incidence of between 5-15%, being one of the most frequent complications reported after surgical surgery, however, not all of them require surgical treatment. This has a multifactorial origin with factors depending on the surgeon, the chosen surgical technique and some components of the deformity not completely corrected during the initial surgery. In cases where this recurrence requires surgical correction, it is a challenge for both the patient and the surgical team, and the success of the treatment depends on correct identification of the cause of failure after primary surgery and correct surgical planning. We present some technical considerations for choosing a minimally invasive osteotomy in this cases. Methods: The inappropriate selection of the technique in a patient with a recurrence of hallux valgus has a high rate of failure. In this sense, we must carry out a precise preoperative evaluation of the patients, both clinical and radiological, using weight-bearing X-rays or even a Weight-bearing CT scan that allows Adequate planning to evaluate rotation and pronation of the metatarsal more reliably, associated with an evaluation of sesamoid subluxation, possible signs of cuneometatarsal instability, such as plantar gap, articular facet obliquity, cortical thickening of the 2nd metatarsal. This also allows us to confirm the presence of metatarsophalangeal arthrosis, or sesamoid metatarsal arthritis that could influence our decision algorithm. Results: Similar to a primary hallux valgus, an asymptomatic deformity should only be observed and if it becomes symptomatic or has a considerable rate of progression, it should be treated surgically. In cases of symptomatic deformities we should always consider the presence of metatarsophalangeal osteoarthritis, medial column instability, if these are not present as indicated by Raikin in his algorithm proposed in 2014, we consider an osteotomy as a revision procedure in a recurrent hallux. In this scenario, we have considered this alternative for selected cases, using the minimally invasive Bosh Akin (MIBA) technique, as a salvage alternative in surgery for recurrences of Hallux valgus. We present a series of 4 feet successfully treated with MIBA osteotomy Conclusion: The application of the miba osteotomy is an effective alternative for the treatment of recurrence of Hallux valgus, which achieves results similar to other open rescue techniques with less aggression of soft tissue
Syndesmotic Reduction Landmarks in Healthy Ankle Patients, Comparative Analysis of Weight- Bearing Computed Tomography
Authors: Redlich Alex , Pellegrini Manuel J. , Carcuro Giovanni M. , Chaparro Felipe R. , Ortiz Cristian A. , Escudero Mario I. , Espinoza Carolina Avilés 
Published: November 2022

Category: Ankle Introduction/Purpose: Introduction: The diagnosis of low-energy syndesmotic injuries continues to be a challenge, and there is no standard for it. Being the dynamic exams, the ones with the best performance. With the development of Weight-Bearing computerized tomography (WBCT), the understanding of their lesion patterns has improved, however, there is high variability in the syndesmotic anatomy between different individuals, with asymmetry parameters in up to 89% of healthy syndesmosis. therefore the best element to evaluate them is the healthy contralateral ankle and compare these parameters. However, what are the normal values in our population, or the possible anatomical differences according to different age groups, in the morphology of the syndesmal notch of our patients, nor that there is a real symmetry between both ankles. Methods: Retrospective analysis of comparative bilateral ankle WBCT in healthy patients from March 2018 to July 2021 according to the parameters: anterior, posterior and central syndesmal distance, fibular rotation, sagittal translation and area. All patients with comparative bilateral ankle weight-bearing CT taken since January 2018 to August 2021, patients without history of ankle injuries, were included in the analysis. That have required a comparative bilateral WBCT to study another pathology. Patients with a history of acute or chronic ankle or syndesmal injuries, patients with degenerative ankle joint injuries, with severe misalignments > 10° in varus or valgus, incomplete or non-comparative study were excluded. Results: 150 patients with comparative bilateral WBCT were evaluated. Among the ankles evaluated with WB CT in a comparative manner, it is established that there were no significant differences between both ankles of subjects with healthy ankles (Wilcoxon Test) in anterior syndesmal distance (SD), posterior SD, central SD, syndesmal area (p > 0.05). While fibular rotation and sagittal translation showed significant differences between the measurements in healthy ankles, evaluated with comparative bilateral WB CT in independent evaluations (p < 0.05). Regarding the differences by age range established for the different syndesmotic reduction parameters, for the different subgroups of patients under 40 years of age, 40 and 60 years of age and over 60 years of age, no significant differences were generated between them (Wilcoxon test). Conclusion: We have established normal ranges for measurements in the syndesmal anatomy in axial slices during weight bearing CT, as well as that there are no differences between the right and left ankle in healthy ankles in anterior, posterior and central syndesmal distance, or syndesmal area. Being these parameters, the most suitable as internal control for patients with suspected syndesmotic injury regardless of the age of the patients.