bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing spatial distribution between 18F-fluorodeoxyglucose and 18F-boronophenylalanine positron emission tomography to investigate selection indicators for boron neutron capture therapy
Authors: Nakaichi Tetsu , Nakamura Satoshi , Ito Kimiteru , Takahashi Kana , Takemori Mihiro , Kashihara Tairo , Kunito Kouji , Murakami Naoya , Iijima Kotaro , Chiba Takahito , Nakayama Hiroki , Mikasa Shohei , Nishio Teiji , Okamoto Hiroyuki , Itami Jun , Kurihara Hiroaki , Igaki Hiroshi 
Published: December 2022

Abstract
Background
18F-FDG PET is often utilized to determine BNCT selection due to the limited availability of 18F-BPA PET, which is performed by synthesizing 18F into the boron drug used for BNCT, although the uptake mechanisms between those are different. Additionally, only a few non-spatial point parameters, such as maximum SUV (SUVmax), have reported a correlation between those in previous studies. This study aimed to investigate the spatial accumulation pattern between those PET images in tumors, which would be expected to either show higher uptake on 18F-BPA PET or be utilized in clinical, to verify whether 18F-FDG PET could be used as a selection indicator for BNCT.

Methods
A total of 27 patients with 30 lesions (11 squamous cell carcinoma, 9 melanoma, and 10 rhabdomyosarcoma) who received 18F-FDG and 18F-BPA PET within 2 weeks were enrolled in this study. The ratio of metabolic tumor volumes (MTVs) to GTV, histogram indices (skewness/kurtosis), and the correlation of total lesion activity (TLA) and non-spatial point parameters (SUVmax, SUVpeak, SUVmin, maximum tumor-to-normal tissue ratio (Tmax/N), and Tmin/N) were evaluated. After local rigid registration between those images, distances of locations at SUVmax and the center of mass with MTVs on each image and similarity indices were also assessed along its coordinate.

Results
In addition to SUVmax, SUVpeak, and Tmax/N, significant correlations were found in TLA. The mean distance in SUVmax was $$25.2 \pm 24.4\; {\text{mm}}$$

25.2
±
24.4

mm

and significantly longer than that in the center of mass with MTVs. The ratio of MTVs to GTV, skewness, and kurtosis were not significantly different. However, the similarities of MTVs were considerably low. The similarity indices of Dice similarity coefficient, Jaccard coefficient, and mean distance to agreement for MTV40 were $$0.65 \pm 0.21$$

0.65
±
0.21

, $$0.51 \pm 0.21$$

0.51
±
0.21

, and $$0.27 \pm 0.30$$

0.27
±
0.30

cm, respectively. Furthermore, it was worse in MTV50. In addition, spatial accumulation patterns varied in cancer types.

Conclusions
Spatial accumulation patterns in tumors showed low similarity between 18F-FDG and 18F-BPA PET, although the various non-spatial point parameters were correlated. In addition, the spatial accumulation patterns were considerably different in cancer types. Therefore, the selection for BNCT using 18F-FDG PET should be compared carefully with using 18F-FBPA PET.
Medication regimen complexity and its impact on medication adherence and asthma control among patients with asthma in Ethiopian referral hospitals
Authors: Belachew Eyayaw Ashete , Netere Adeladlew Kassie , Sendekie Ashenafi Kibret 
Published: December 2022

Abstract
Background
Various studies have found that medication adherence is generally low among patients with asthma, and that the complexity of the regimen may be a potential factor. However, there is no information on the complexity of the regimen and its relationship to adherence and asthma outcomes in Ethiopian asthma patients. Therefore, this study assessed how complex medication regimens affected medication adherence and asthma control in patients with asthma.

Method
From February 1 to May 30, 2022, a multicenter cross-sectional study was conducted in three public referral hospitals in northwestern Ethiopia. The Medication Complexity Index (MRCI), a 65-item validated instrument, was used to represent the complexity of medication regimens The Medication Adherence Rating Scale for Asthma (MARS-A) was used to assess medication adherence, and the ACT was used to measure the level of asthma control. The association between predictor and outcome variables was determined using multivariable logistic regression analysis. P-values of < 0.05 were declared as a significant association.

Result
Patients with asthma (n = 396) who met the inclusion criteria were included in the final analysis. About 21.2% and 24.5% of the participants had high asthma-specific MRCI and patient-level MRCI, respectively. The majority (84.4%) of the participants did not adhere to their medication, and 71% of the participants were classified as having uncontrolled asthma. According to the result of the multivariable analysis, moving from a high asthma-specific MRCI to a moderate asthma MRCI enhances the likelihood of medication adherence by 2.51 times (AOR = 2.51, 95%CI: (1.27, 7.71). Likewise, patients who have low asthma MRCI were four times more likely to adhere to the medication compared with high asthma MRCI (AOR = 3.80, 95%CI: (2.0, 11.1). Similarly, patients having low patient-level MRCI were eight times more likely their asthma level had been controlled (AOR = 7.84, 95%CI: 1.46 to 21.3) and patients who had moderate patient-level MRCI were three times (AOR = 2.83, 95%CI: 1.05 to 8.25) more controlled asthma compared with patients who had high patient level MRCI.

Conclusion
The majority of asthma patients had low and moderate complexity of MRCI. Patients with low and moderate regimen complexity demonstrated high adherence and had well-controlled asthma. Therefore, future researchers should consider MRCI as one factor for adherence and asthma control levels.
Federated learning for 5G-enabled infrastructure inspection with UAVs
Authors: Lekidis Alexios 
Published: December 2022

AbstractElectricity infrastructures include assets that require frequent maintenance, as they are exposed into heavy use, in order to produce energy that satisfies customer demands. Such maintenance is currently performed by specialized personnel that is scaffolding to spot damages or malfunctioning equipment. Scaffolding is time-consuming and incurs accident risks. To tackle this challenges, grid operators are gradually using Unmanned Aerial Vehicles (UAVs). UAV trajectories are observed by a centralized operation center engineers for identifying electrical assets. Moreover, asset identification can be further automated through the use of Artificial Intelligence (AI) models. However, centralized training of AI models with UAV images may cause inspection delays when the network is overloaded and requires Cloud environments with enough processing power for model training on the operation center. This imposes privacy concerns as sensitive data is stored and processed externally from the infrastructure facility. This article proposes a federated learning method for UAV-based inspection that leverages a Multi-access Edge Computing platform installed in edge nodes to train UAV data and improve the overall inspection autonomy. The method is applied for the inspection of the Public Power Corporation’s Innovation Hub. Experiments are performed with the proposed method as well as with a centralized AI inspection method and demonstrate the federated learning benefits in reliability, AI model processing time and privacy conservation.
Association of physical activity with the risk of major adverse cardiac and cerebrovascular events and mortality in patients with concomitant atrial fibrillation and coronary artery disease
Authors: Jin Moo-Nyun , Seo Jongkwon , Kim Byung Gyu , Kim Gwang Sil , Lee Hye Young , Byun Young Sup , Kim Byung Ok 
Published: December 2022

Abstract
Background
Although regular physical activity benefits cardiovascular health, there is a concern that intense exercise is linked to the promotion of atrial fibrillation (AF) and coronary plaque rupture. However, the impact of physical activity on the outcomes of patients with concomitant AF and coronary artery disease (CAD) remains unclear. This study aimed to evaluate the association with clinical outcomes according to the level of physical activity in patients with concomitant AF and CAD.

Methods
We assessed 551 patients with AF and CAD (mean age, 67.1 ± 9.8 years) who completed a self-reported questionnaire for physical activity from 2015 to 2020 in a single tertiary-care hospital. Physical activity levels were converted into metabolic equivalent of task (MET) per week and categorized to correspond with multiple public health recommendations. We examined the association between physical activity, all-cause mortality, and major adverse cardiac and cerebrovascular events (MACCE).

Results
The risks of all-cause mortality (P for linear trend = 0.017) and MACCE (P for linear trend = 0.05) appeared inverse trend with a greater level of physical activity. Compared with inactive patients, patients who met the recommended target range of physical activity (500–1,000 MET-min/week: unadjusted hazard ratio [HR] = 0.58, 95% confidence interval [CI] = 0.36–0.99) and highly active patients who exceeded the minimum recommended level (≥ 1,000 MET-min/week: unadjusted HR = 0.47, 95% CI = 0.25–0.88) had a lower risk of all-cause mortality in the unadjusted model; however, these associations did not remain significant after adjusting for the model. There was no evidence of increased risk of all-cause mortality and MACCE at levels of physical activity above the recommended target range, even with vigorous-intensity physical activity exceeding the recommended target range.

Conclusions
There appears to be an inverse trend between physical activity levels and all-cause mortality and MACCE in patients with concomitant AF and CAD. No excess risk of mortality or MACCE was found at exercise levels above the recommended target range. Further large-scale studies are warranted to create an improved evidence base concerning the effects of physical activity in patients with AF and CAD.
Antimicrobial resistance and molecular typing of Salmonella in the chicken production chain in Hubei Province, China
Authors: Wu Cuirong , Liu Lihui , Sui Yuxin , Huang Lulu , Chen Yang , Hao Haihong , Pan Yuanhu , Liu Zhenli , Cheng Guyue 
Published: December 2022

AbstractSalmonella is a significant foodborne zoonotic pathogen that endangers both human and animal health. The goal of this research is to gain a preliminary understanding of Salmonella contamination and antimicrobial resistance in the chicken production chain in Hubei Province, China. 1149 animal and environmental samples were collected from chicken farms, slaughterhouses, and retail markets in six cities across Hubei Province in China from 2019 to 2020, yielding Salmonella isolation rates of 4.68% (28/598), 12.21% (47/385), and 9.64% (16/166), respectively. Seventeen distinct serotypes were detected among 53 non-clonal Salmonella strains, of which Meleagridis (26.42%, 14/53) was the dominant serotype. Almost half of the strains (49.06%, 26/53) were multi-drug resistant (MDR). Whole-genome sequencing (WGS) showed that 10 resistance genes (tetA, blaTEM, parC, qnrS1, floR, aac(6′)-Iy, aph(6)-Id, aph(3″)-Ib, aac(6′)-Iaa and sul2) and 7 categories of virulence genes were present in all three links in 22 non-clonal dominant serotype strains. It was shown that Salmonella in the chicken production chain in Hubei Province had a high resistance rate to Tetracycline (TET, 73.58%), Ofloxacin (OFL, 69.81%), Florfenicol (FFC, 60.38%) and Ampicillin (AMP, 39.62%) which was consistent with the widespread use of these drugs in the husbandry industry in China. Salmonella ST types determined by MLST and serotypes determined by WGS had a one-to-one correlation. Minimum spanning tree analysis revealed that there was cross contamination of Salmonella in farms and slaughterhouses, slaughterhouses and markets, animal samples and environmental samples. This work provides useful information for the prevention and control of contamination and antimicrobial resistance of Salmonella in the chicken production chain, as well as demonstrating the dependable role of WGS in Salmonella molecular typing.
A new tool for assessing the cultural adaptation of cognitive tests: demonstrating the utility of the Manchester Translation Evaluation Checklist (MTEC) through the Mini-Mental State Examination Urdu
Authors: Mirza Nadine , Waheed Muhammed Wali , Waheed Waquas 
Published: December 2022

Background
Low- and middle-income countries contribute to the majority of dementia and mild cognitive impairment cases worldwide, yet cognitive tests for diagnosis are designed for Western cultures. Language and cultural discrepancies mean that translated tests are not always reliable or valid. We propose a model for culturally adapting cognitive tests, one step of which is to assess the quality of any translation and cultural adaptation undertaken. We developed the Manchester Translation Evaluation Checklist (MTEC) to act as a tool for quality assessment and demonstrated its use by assessing a popular cognitive test that had been adapted.

Aims
Assess quality of the translation and cultural adaptation of the Urdu Mini-Mental State Examination developed for a Pakistani population.

Method
Two raters completed the MTEC for the Mini-Mental State Examination (MMSE) Urdu and compared feedback. All authors were fluent in English and Urdu and familiar with Pakistani culture.

Results
Raters had 78.5% agreement across the MTEC. The MMSE Urdu was appropriately translated and retained grammar and verb tense, but three questions had spelling errors. Across 20 MMSE questions, 5 required further cultural adaptation because the questions were not understandable in daily use, comfortable to answer, relevant to the language and culture, and relevant to original concepts.

Conclusions
The MTEC highlighted errors in the MMSE Urdu and demonstrated how this tool can be used to improve it. Future studies could employ the MTEC to improve existing translated measures of health assessment, particularly cognitive tests, and act as a quality check when developing new adaptations of tests and before psychometric validation.
Analysing spatiotemporal instabilities in magneto-optical traps with the tools of turbulence theory
Authors: Griffin Adam , Gaudesius Marius , Kaiser Robin , Nazarenko Sergey , Labeyrie Guillaume 
Published: December 2022

Abstract
A large cloud of 87Rb atoms confined in a magneto-optical trap exhibits, in a certain regime of parameters, spatiotemporal instabilities with a dynamics resembling that of a turbulent fluid. We apply the methods of turbulence theory based on structure function analysis to extract scaling exponents which are compared to known turbulent regimes. This analysis also allows us to make a clear distinction between different instability regimes.
Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants
Authors: Wang Jun , Thomas Holly R. , Thompson Robert G. , Waldrep Stephanie C. , Fogerty Joseph , Song Ping , Li Zhang , Ma Yongjie , Santra Peu , Hoover Jonathan D. , Yeo Nan Cher , Drummond Iain A. , Yoder Bradley K. , Amack Jeffrey D. , Perkins Brian , Parant John M. 
Published: December 2022

ABSTRACT
Meckel syndrome, nephronophthisis, Joubert syndrome and Bardet–Biedl syndrome are caused by mutations in proteins that localize to the ciliary transition zone (TZ). The phenotypically distinct syndromes suggest that these TZ proteins have differing functions. However, mutations in a single TZ gene can result in multiple syndromes, suggesting that the phenotype is influenced by modifier genes. We performed a comprehensive analysis of ten zebrafish TZ mutants, including mks1, tmem216, tmem67, rpgrip1l, cc2d2a, b9d2, cep290, tctn1, nphp1 and nphp4, as well as mutants in ift88 and ift172. Our data indicate that variations in phenotypes exist between different TZ mutants, supporting different tissue-specific functions of these TZ genes. Further, we observed phenotypic variations within progeny of a single TZ mutant, reminiscent of multiple disease syndromes being associated with mutations in one gene. In some mutants, the dynamics of the phenotype became complex with transitory phenotypes that are corrected over time. We also demonstrated that multiple-guide-derived CRISPR/Cas9 F0 ‘crispant’ embryos recapitulate zygotic null phenotypes, and rapidly identified ciliary phenotypes in 11 cilia-associated gene candidates (ankfn1, ccdc65, cfap57, fhad1, nme7, pacrg, saxo2, c1orf194, ttc26, zmynd12 and cfap52).
Surgical Outcome After Pancreatoduodenectomy for Duodenal Adenocarcinoma Compared with Other Periampullary Cancers: A Nationwide Audit Study
Authors: de Bakker Jacob K. , Suurmeijer J. Annelie , Toennaer Jurgen G. J. , Bonsing Bert A. , Busch Olivier R. , van Eijck Casper H. , de Hingh Ignace H. , de Meijer Vincent E. , Molenaar I. Quintus , van Santvoort Hjalmar C. , Stommel Martijn W. , Festen Sebastiaan , van der Harst Erwin , Patijn Gijs , Lips Daan J. , Den Dulk Marcel , Bosscha Koop , Besselink Marc G. , Kazemier Geert ,   for the Dutch Pancreatic Cancer Group
Published: December 2022

Abstract
Background
Surgical outcome after pancreatoduodenectomy for duodenal adenocarcinoma could differ from pancreatoduodenectomy for other cancers, but large multicenter series are lacking. This study aimed to determine surgical outcome in patients after pancreatoduodenectomy for duodenal adenocarcinoma, compared with other periampullary cancers, in a nationwide multicenter cohort.

Methods
After pancreatoduodenectomy for cancer between 2014 and 2019, consecutive patients were included from the nationwide, mandatory Dutch Pancreatic Cancer Audit. Patients were stratified by diagnosis. Baseline, treatment characteristics, and postoperative outcome were compared between groups. The association between diagnosis and major complications (Clavien–Dindo grade III or higher) was assessed via multivariable regression analysis.

Results
Overall, 3113 patients, after pancreatoduodenectomy for cancer, were included in this study: 264 (8.5%) patients with duodenal adenocarcinomas and 2849 (91.5%) with other cancers. After pancreatoduodenectomy for duodenal adenocarcinoma, patients had higher rates of major complications (42.8% vs. 28.6%; p < 0.001), postoperative pancreatic fistula (International Study Group of Pancreatic Surgery [ISGPS] grade B/C; 23.1% vs. 13.4%; p < 0.001), complication-related intensive care admission (14.3% vs. 10.3%; p = 0.046), re-interventions (39.8% vs. 26.6%; p < 0.001), in-hospital mortality (5.7% vs. 3.1%; p = 0.025), and longer hospital stay (15 days vs. 11 days; p < 0.001) compared with pancreatoduodenectomy for other cancers. In multivariable analysis, duodenal adenocarcinoma was independently associated with major complications (odds ratio 1.14, 95% confidence interval 1.03–1.27; p = 0.011).

Conclusion
Pancreatoduodenectomy for duodenal adenocarcinoma is associated with higher rates of major complications, pancreatic fistula, re-interventions, and in-hospital mortality compared with patients undergoing pancreatoduodenectomy for other cancers. These findings should be considered in patient counseling and postoperative management.
Standardized instruments for assessing psychiatric, behavioral, sexual problems, and quality of life in male and female adults with disorders of sex development in Indonesia
Authors: Purwanto Haryo Prakoso Adhi , Wahyudi Irfan 
Published: December 2022

Disorders of Sex Development (DSD) are a group of congenital medical conditions defined as atypical development of chromosomal, gonadal, and anatomical sex. Psychiatric, behavioral, and gender-associated problems could arise in both male and female adult with DSD. Structured assessments for each variable are needed to properly measure psychiatric and sexual issues and overall quality of life in adults with DSD. This study aims to review structured questionnaire instruments that had been used to assess psychiatric, behavioral, sexual problems, and quality of life in adults with DSD.For psychiatric or behavioral problems, adults with DSD can be assessed with GHQ-28, Brief Symptoms Inventory, Achenbach and Rescorla’s Adult Behavior Checklist, Rosenberg Self-esteem Scale, Mini International Neuropsychiatric Interview plus, Hospital anxiety and depression scale, Body image scale, Adult ADHD self-report scale screener, Short Autism Spectrum Quotient, and coping with DSD questionnaire. For quality of life, assessment could be done with WHOQOL and Short Form-36. Gender role assessment in adults with DSD can be done using Core Gender Identity, Sexual Orientation, and Gender Role Behavior and Utrecht Gender Dysphoria Scale. Both of the apparent male and female DSD patients can be assessed using the instruments available. Recommendations are made based on its function, compliance, validity, reliability, and avaibility of an Indonesian version of the questionnaire.There are a plethora of structured questionnaire tools that have been used to measure psychiatric or behavioral problems, quality of life, and gender roles in adult with DSD, each with its own advantages and disadvantages
Elder abuse in Saudi Arabia: A systematic review
Authors: Alqahtani Ali S. , Alanazi Ammer L. , alsayyali Ziyad K. , Almubarak Khalid Z. , Alzahrani Nasser N. , Bokhari Amr R. , Menezes Ritesh G. 
Published: December 2022

Background: Elder abuse is a common global problem that is certainly preventable. The first step to tackling elder abuse is by researching its prevalence and acknowledging it as a prevailing problem. However, there is a lack of studies on elder abuse in Saudi Arabia. In this review, the socio-forensic problem of elder abuse in Saudi Arabia is addressed. Methods: The PubMed database was systematically searched for articles on elder abuse in Saudi Arabia from inception to 1 July 2022. Search terms included “elder abuse”, “elderly abuse”, “geriatric abuse”, “aged abuse”, “senior abuse”, and “elder maltreatment”. In addition, to detect studies reported from Saudi Arabia, the following search terms were included: “Saudi Arabia”, “KSA”, and “Kingdom of Saudi Arabia”. The search results were screened for relevant articles. Studies from Saudi Arabia that addressed elder abuse were included in this review. Studies from other countries and studies that addressed abuse in other age groups were excluded. Results: A very high percentage of the elderly in shelter homes were found to have experienced abuse, especially psychological, which resulted in an array of mental health implications such as anxiety, depression, and sleep disorders. A high level of awareness of elder abuse, in addition to a high sense of responsibility towards the elderly, was reported. Conclusions: As the elderly represent a significant percentage of the population in Saudi Arabia, and with the community being heavily family-centered, it is recommended to increase dedicated efforts towards nationwide research on elder abuse and to formulate effective national programs to ensure its prevention in Saudi Arabia.