bluuebunny/crossref_metadata_2025_split huggingface dataset:
CLINICAL CHARACTERISTICS OF PATIENTS WITH SPONTANEOUS CERVICAL ARTERY DISSECTION - THE POLISH REGISTRY FOR FIBROMUSCULAR DYSPLASIA (ARCADIA-POL STUDY)
Authors: Sasin Dawid , Talarowska Paulina , Januszewicz Magdalena , Jozwik-Plebanek Katarzyna , Dobrowolski Piotr , Prejbisz Aleksandrer , Florczak Elzbieta , Gasecki Dariusz , Zylkowski Jaroslaw , Michalowska Ilona , Kabat Marek , Persu Alexandre , Januszewicz Andrzej 
Published: June 2022

Objective:
To assess the clinical characteristics of patients with spontaneous cervical artery dissection enrolled into ARCADIA-POL study.

Design and method:
Out of 435 patients enrolled into ARCADIA-POL study since January 2015 (instituted on the basis of Polish-French collaboration) we present 77 consecutive patients with confirmed spontaneous cervical artery dissection (SCeAD) which was one of the inclusion criteria to the study. A standardized fibromuscular dysplasia (FMD) data form was used for data collection. All patients underwent detailed clinical evaluation including ABPM, biochemical evaluation, biobanking and imaging, duplex Doppler of carotid and abdominal arteries and whole body angio-CT.

Results:
In our analysis we included 77 patients with confirmed SCeAD (50F [64.9%], 27 M [35.1%], mean age: 43.9 +/- 9.6). Dissection involved internal carotid artery in 53 (68.8%) patients, vertebral artery in 19 (24.7%) patients and 5 (6.5%) patients presented coexisting vertebral and carotid artery dissection. FMD was confirmed in 27 (35.1%) patients – 22 of patients in one and in 5 patients in two or more vascular beds. Among patients with cervical artery dissection coexisting with FMD, the most frequent localization of FMD lesions were carotid arteries (66.7%) and renal arteries (44.4%) and subclavian artery in one patient. Hypertension was diagnosed in 59.7% of patients. 27 female patients (54%) confirmed usage of hormonal contraception agents in the medical history. The most frequent clinical symptoms associated with the occurrence of cervical artery dissection in the analyzed group were headaches (70.1%), vision disturbances (39%), dizziness (39%), eye pain (40%) and neck pain (37.7%). In 31 patients (40.3%) cervical artery dissection was associated with ischemic stroke and in 9 patients (11.7%) with transient ischemic attack.

Conclusions:
Systematic evaluation by means of whole-body angio-CT of patients with SCeAD confirmed FMD in 1 out of 3 patients. Our data confirms that FMD should be considered as systematic disease with clinical presentation ranging from asymptompatic changes to life-threatening conditions such as SCeAD.
THE EFFECTS OF INDUCED BLOOD PRESSURE INCREASE AND DECREASE ON CEREBRAL SMALL VESSELS: THE HYPERINTENSE STUDY
Authors: Janssen Esther , Ter Telgte Annemieke , Verburgt Esmée , De Jong Joost , Marques José , Kessels Roy , Backes Walter , Maas Marnix , Meijer Anton , Deinum Jaap , Riksen Niels , Tuladhar Anil , De Leeuw Frank-Erik 
Published: June 2022

Objective:
Cerebral Small vessel disease (SVD) is a disorder of the cerebral microvessels and is the commonest vascular cause of stroke and dementia. Hypertension is the most established risk factor for SVD, but the pathophysiological mechanisms following hypertension that cause SVD remain poorly understood. We aim to examine the effects of changes in blood pressure on cerebral microvasculature in young- and middle-aged adults with hypertension to detect the earliest microvascular changes associated with SVD.

Design and method:
The Hyperintense study is an ongoing observational cohort study aiming to include 50 hypertensive adults (18–55 years). These patients temporarily discontinue antihypertensive medication for diagnostic purposes, often leading to a temporary increase in blood pressure. Data are collected before medication withdrawal (T = 0), once antihypertensives are withdrawn (T = 1), when patients have restarted medication and reached target blood pressure (T = 2) and 1 year later (T = 3). At each time-point, high-resolution 3T MRI scans are performed with conventional structural sequences and advanced techniques to assess various aspects of microvascular integrity, including integrity of the blood-brain barrier, microperfusion and microstructural integrity. Clinical data includes motor and cognitive examinations and blood sampling.

Results:
Between July-December 2021, 7 patients (86% male, mean age 47.4 ± 4.4 years) were enrolled. Baseline characteristics and SVD burden are shown in Table. In 3/4 participants who completed T = 1, systolic blood pressure increased after medication withdrawal (median increase systolic blood pressure: 13.7 [3.3 – 15.3] mmHg), demonstrating proof of principle of our approach.

Conclusions:
First data show increased blood pressure after medication withdrawal in most participants and demonstrate feasibility of our design. Analysis of the effect of blood pressure increase and decrease on MRI outcomes will improve understanding of the pathological mechanisms following hypertension that may lead to MRI markers of SVD. This knowledge can help identify new targets for treatment of SVD, aimed at preventing or limiting disease progression.
ARTERIAL STIFFNESS GRADIENT PREDICTS INDEPENDENTLY FUNCTIONAL OUTCOME AFTER ISCHEMIC STROKE
Authors: Gasecki Dariusz , Kwarciany Mariusz , Kowalczyk Kamil , Rojek Agnieszka , Narkiewicz Krzysztof , Karaszewski Bartosz 
Published: June 2022

Objective:
Arterial stiffness is a strong predictor of morbidity in various clinical conditions, including ischemic stroke. However, the prognostic significance of the newly emerged aortic–brachial arterial stiffness gradient, defined as carotid–femoral/radial -carotid pulse wave velocity (PWV ratio) for functional outcome in ischemic stroke remains unknown.

Design and method:
We enrolled 144 patients (114 males, age 63.1 ± 12.4 years, mean ± SD) with acute ischemic stroke (NIHSS score at admission 6.6 ± 5.3 points). Carotid-femoral pulse wave velocity (PWV), radial –carotid PWV and peripheral blood pressure (BP) were measured (SphygmoCorâ) within several (6 ± 2) days after stroke onset. Functional outcome was evaluated 90 days after stroke using the modified Rankin Scale (mRS) with an mRS score of 3 to 6 (dependency or death) considered as a poor outcome.

Results:
PWV ratio was higher in patients with a poor stroke outcome than in patients of the reference group (1.34 ± 0.58 vs 1.17 ± 0.30; p = 0.017). In a multivariate analysis, the predictive value of PWV ratio remained significant (OR, 3.62; 95% CI, 1.04–12.75; p = 0.044) after adjustment for covariates. In contrast, CF PWV had no significant predictive value for stroke poor outcome.

Conclusions:
We found that the higher PWV ratio in patients in the subacute phase of ischemic stroke is independently associated with a poor outcome. This PWV index might be useful in clinical practice, including therapeutic decisions, but needs broader studies in patient populations of stroke subtypes.
OFFICE VERSUS HOME BLOOD PRESSURE VARIABILITY IN YOUNG INDIVIDUALS: COMPARISON AND ASSOCIATION WITH PRECLINICAL ORGAN DAMAGE
Authors: Zeniodi Maria-Elena , Ntineri Angeliki , Kollias Anastasios , Servos George , Moysakis Ioannis , Destounis Antonios , Vazeou Andriani , Stergiou George S. 
Published: June 2022

Objective:
Studies in adults showed that blood pressure (BP) variability has independent prognostic value for cardiovascular outcome. This study investigated the relationship between office and home BP variability with indices of preclinical target organ damage in young individuals.

Design and method:
Healthy individuals aged 6–25 years referred for elevated BP and healthy volunteers were subjected to BP measurements in the office (2–3 visits, triplicate measurements, mercury sphygmomanometer) and at home (6–7 school/work days, duplicate morning and evening measurements, validated oscillometric arm-cuff devices) within 4 weeks. BP variability was quantified as the standard deviation and coefficient of variation of visit-to-visit office BP and day-to day home BP. Preclinical organ damage was assessed with ultrasonographic evaluation of left ventricular mass index (LVMI), determination of common carotid intima-media thickness (cIMT) and pulse wave velocity (PWV, piezoelectronic principle).

Results:
233 individuals were analyzed (age 14.1 ± 4.0 years, 72% males, 32% children, 53% adolescents, 15% young adults, 4.3% healthy volunteers, 29.6% with office and 25.3% with home hypertension). All participants had office and home BP measurements and evaluation of at least one index of target organ damage (LVMI 189, cIMT 123, PWV 73). The variability of systolic office BP was higher than home (p < 0.05) whereas there was not such a difference for diastolic BP variability (Table). None of the office and home BP variability indexes exhibited a statistically significant association with LVMI, cIMT or PWV.

Conclusions:
This study in healthy children, adolescents and young adults showed higher systolic office than home BP variability, but none of them was associated with preclinical organ damage. The clinical relevance of BP variability, and the optimal index and method for its evaluation remain undefined and require further investigation.
ROLE OF SEROTONIN AND ITS METABOLITE 5-HIAA IN THE DEVELOPMENT OF PULMONARY HYPERTENSION. NEW APPROACHES TO TREATMENT AND NON-INVASIVE DIAGNOSTICS?
Authors: Bilalova Diana , Nigmatullina Razina , Mustafin Alvar 
Published: June 2022

Objective:
Development of new methods for diagnostics and new approaches to treatment of PAH from the standpoint of serotonergic regulation.
The obtained data points out that a potential marker of PAH is an increase in the concentration of 5-HIAA in urine which is shown by a positive correlation with the stage of PAH.

Design and method:
I.The patients (n = 43, 20 days - 16 y.o.):
Patients with congenital heart disease (CHD) and severe PAH;
Patients with CHD with mild to moderate PAH;
Healthy children (controls).
II.PAH was induced in immature rats by subcutaneous injection of monocrotaline (MCT) (60 mg / kg) at the age of 4 weeks. The studies were carried out 1, 2, 4 weeks after the administration of MCT, namely:
- study of 5-HIAA in urine in ELISA
- invasive study of pressure in the right heart and pulmonary artery
- immunohistochemical and morphological examination of the right and left ventricle, pulmonary artery and aorta.

Results:
A statistically significant increase in pressure in the right ventricle was found in MIPHM, which indicates the adequacy of the selected model of PAH;
- Patients with PH have significantly increased plasma 5-HIAA levels compared to other groups;
- There were statistically significant intergroup differences in amount of 5-HIAA in urine;
- Direct positive dependence of amount of 5-HIAA in urine on the stage of PAH was revealed.

Conclusions:
Comparing the data of our studies, it can be concluded that 5-HIAA levels characterize the activity of pathogenetic processes in PAH. Thus, the possibility of plasma or urine 5-HIAA levels measurement in order to assess the severity of PAH and the effectiveness of its therapy is assumed.
The hypothesis based on our results give us the opportunity to continue working in direction with the aim of introducing drugs of 5-HT receptor antagonists class for the PAH therapy. Simplicity, availability and non-invasiveness of the assessment method of PAH process activity makes it promising to introduce the determining of 5-HIAA levels in urine in the clinical pathology of the PAH stage and the effectiveness of its therapy.
THE EFFECT OF A DIGITAL HEALTH INTERVENTION ON THE CONTROL OF HYPERTENSION AMONG PEOPLE LIVING WITH CANCER
Authors: Okpara Chinelo , Mobisson Nneka , Moosa Maria , Rahman Km Jawadur , Akpakli Jonas , Ogboye Ayoposi , Raji Blessing 
Published: June 2022

Objective:
To examine the effectiveness of a digital health intervention on the control of hypertension among people living with cancer.

Design and method:
This was a retrospective study of 101 participants (average age of 67 years old) living with cancer and hypertension enrolled on mDoc’s digital CompleteHealthô platform between February 2020 to November 2021.
The people were connected with a coach-led multidisciplinary team that provided self-care support and encouragement via CompleteHealthô. The multidisciplinary team engaged the people with regular digital nudges on monitoring their blood pressure, health education, nutritional advice, virtual exercise classes and co-created personalised action plans with them. Specialised support for their cancer diagnosis included ensuring adherence to their oncology treatment regimens. The change in blood pressure was calculated as the difference between their initial blood pressure value and the average of all subsequent blood pressure values entered on CompleteHealthô.

Results:
Of the 101 people with cancer and hypertension enrolled on the CompleteHealthô, 98 (97.0%) had at least one interaction with a health coach and 84 (83.2%) entered at least 1 subsequent blood pressure value after their baseline while 57 (56.4%) of them had entered at least 5 subsequent values. Of those with at least 1 value, 63 (75%) had a controlled BP while 48 (84.2%) of those with at least 5 values had controlled BP at the end-line. People with at least 1 subsequent value saw a change of 0.3 mmHg and 1.3 mmHg in their systolic and diastolic blood pressure respectively while people with at least 5 values saw a 2 mmHg and 1.7mmHg reduction in their systolic and diastolic blood pressures respectively.

Conclusions:
Our findings show that a digital health intervention was able to help people living with cancer and hypertension reduce their blood pressure via the use of a web platform, digital nudges, encouragement on the need to check blood pressure at home, exercise, and modification of lifestyles. It also showed that a greater number of interactions with the health coaches led to a greater reduction in blood pressure.
SIMILARITIES IN DEPRESSION AND ANXIETY BETWEEN WHITE-COAT AND RESISTANT HYPERTENSION
Authors: Nemcsik János , Korosi Beata , Gyongyosi Helga , Batta Dora , Laszlo Andrea , Kovacs Illes , Nemcsik-Bencze Zsofia , Rihmer Zoltan , Gonda Xenia 
Published: June 2022

Objective:
Hypertension is a major risk factor of cardiovascular mortality. Mood disorders represent a growing public health problem worldwide. A complex relationship is present between mood disorders and cardiovascular diseases. However, less data is available about the level of depression and anxiety in different hypertension phenotypes. The aim of our study was to evaluate psychometric parameters in healthy subjects (Cont), in patients with white-coat hypertension (WhHT), with chronic, non-resistant hypertension (non-ResHT), and with chronic, treatment-resistant hypertension (ResHT).

Design and method:
In this cross-sectional study, 363 patients were included: 82 Cont, 44 WhHT, 200 non-ResHT and 37 ResHT. The patients completed the Beck Depression Inventory (BDI) and the Hamilton Anxiety Scale (HAM-A).

Results:
BDI points were higher in WhHT (7 (3–11)) and ResHT (6 (3–11.5)) compared with Cont (3 (1–6), p < 0.05). Similarly, HAM-A points were higher in WhHT (8 (5–15)) and ResHT (10.5 (5.25–18.75)) compared with Cont (4 (1–7), p < 0.05) and also compared with non-ResHT (5 (2–10), p < 0.05). ResHT was independently associated with HAM-A scale above 3 points (Beta = 3.804, 95%CI: 1.204–12.015). WhHT was independently associated with HAM-A scale above 2 (Beta = 7.701, 95%CI: 1.165–18.973) and BDI scale above 5 (Beta = 2.888, 95%CI: 1.170–7.126) points.

Conclusions:
The evaluation of depression and anxiety in hypertensive patients could be useful to identify subjects with risk of white-coat effect and resistant hypertension. Our results suggest the possibility of the progression of white-coat hypertension to resistant hypertension in longer term, however, the proof of this concept requires prospective studies.
THE RELATIONSHIPS BETWEEN ANXIETY AND BLOOD PRESSURE DYNAMICS UNDER THE ANTIHYPERTENSIVE TREATMENT
Authors: Fedorishina Olga , Protasov Konstantin , Torunova Anna 
Published: June 2022

Objective:
To study the dynamics of the relationship between anxiety and blood pressure (BP) in patients with hypertension (HTN).

Design and method:
The 24-hour BP monitoring was performed and the presence and severity of anxiety using the Hospital Anxiety and Depression Scale questionnaire were investigated in 171 patients (89 man and 82 woman aged 51.1 ± 8.2) with untreated HTN. Then the patients were assigned to standard antihypertensive therapy. The studies were repeated after 6 months. The dynamics of BP and anxiety during the follow up period were evaluated. Were used comparative, Spearman’s correlation and regression analysis for this purpose.

Results:
The mean anxiety score in the whole group of patients initially was within the normal range (6.2 ± 3.4), but anxiety disorders were detected (>7 points) in 61 patients (35.7%).
According to the anxiety dynamics the patients were divided into 4 groups. The 1st one consisted of patients in whom the anxiety persistent throughout 6 month (n = 29). In the 2nd group initially increased level of anxiety normalized by the observation (n = 32). The 3rd group included patients with no anxiety syndrome at baseline and after 6 months (n = 101) and 4th – normal level of anxiety at baseline and elevated after 24 weeks (n = 9).
The office and 24-hour BP significantly decreased in all groups during the treatment. The degree of systolic BP decrease in the groups did not differ, at the same time the degree of decrease in diastolic BP was less pronounced in the second group (-8.9 mmHg) compared with the first (-13.9 mmHg, p = 0.014) and the third (-12 .7 mm Hg, p = 0.011).
The achievement of 24-hour BP < 130/80 mmHg was associated with the of anxiety reduction degree using both by Spearman’s correlation (r = + 0.16, p = 0.031) and by logistic analysis (OR 1.188; 95% CI 1.049–1.346; p = 0.007) adjusted for gender and age. No relationship was found between achieving the target office BP and anxiety dynamics.

Conclusions:
The least effective of antihypertensive therapy was noted in patients with normalization of the initially elevated anxiety levels. The probability of achieving the target of the 24-hour BP pressure increases as anxiety level grows over time.
INCIDENCE AND PROGNOSTIC IMPACT OF TYPE 1 CARDIO-RENAL SYNDROME IN PATIENTS ADMITTED FOR ACUTE CORONARY SYNDROME
Authors: Cherif Abdelghani Bachir , Bennouar Salam 
Published: June 2022

Objective:
To assess the incidence and prognostic impact of cardio-renal syndrome (CRS) in a population of patients admitted for an acute coronary syndrome (ACS),

Design and method:
This was a retrospective cohort study of 952 patients with ACS. An information sheet was established for data collection. Cumulative survival rates were obtained by the Kaplan Meier method, survival curves were compared by the Log-Rank test, the ROC curve was used to define the cut-offs of the markers of renal function to predict mortality

Results:
The incidence of cardio-renal syndrome was 54.8%, and it was more frequent in women, elderly subjects, hypertensives and diabetics. The cut-offs of creatinine and uremia to predict mortality were 15.7 mg/l and 0.65 g/l respectively. Cumulative survival rates were lower in the group of patients with CRS-1.

Conclusions:
The cardio-renal syndrome is a frequent complication in patients admitted for ACS. Creatinine levels, as well as uremia, are easy to measure, accessible, and very inexpensive parameters that have very satisfactory predictive capacities in the context of CRS-1
PHYSICAL ACTIVITY AND LIFESTYLE CHANGES IN ITALY DURING THE COVID-19 LOCKDOWN: GENDER DIFFERENCES
Authors: Pellegrino Alessio , Rosselli Martina , Orlandi Melissa , Boddi Maria , Stefani Laura , Toncelli Loira , Modesti Pietro Amedeo 
Published: June 2022

Objective:
Italy responded to the Covid-19 pandemic early by forcing the entire population into a 2-month domestic confinement. The aim of this study was to assess gender differences in the impact of lockdown on physical activity and lifestyle habits.

Design and method:
A cross-sectional web-based survey was conducted in April 2020 on a general population sample residing in Italy. Participants completed validated questionnaires. Gender differences were assessed using a multivariable adjusted logistic regression model using gender as independent and exposures as dependent variables. Metabolic equivalents-hour/week was used to evaluate physical activity.

Results:
A total of 2218 participants (761 men and 1457 women) agreed to participate in the study and completed the questionnaire. The survey found that women compared to men showed 1) a lower level of physical activity before the institution of lockdown, 2) a lower tendency to reduce physical activity levels during the lockdown, when gender differences in compliance with guideline recommendations for physical activity disappeared, 3) and a worsening of sleep and tool passage; men experienced an increase in alcohol consumption.

Conclusions:
Women, who previously had a lower level of physical activity than men, showed a lower tendency to reduce it during lockdown, revealing greater resilience than men. However, the worsening in sleep, in stool passage, and a trend to weight increase revealed signs of psychological suffering after a protracted lockdown period.
CONTINUES REMOTE CARDIAC MONITORING IN CRITICALLY ILL COVID-19 PATIENTS (C3 STUDY)
Authors: Rajanna Avinash Hanbe , Kumar Jeetendra 
Published: June 2022

Objective:
To evaluate the use of remote cardiac monitoring of critically ill COVID-19 patients.
To correlate DOZEE early warning score(DEWS) with severity and outcome

Design and method:
Ballistocardiography (BCG)Ballistocardiography is a non-invasive method based on the measurement of the body motion generated by the ejection of the blood at each cardiac cycle. It also contains motion arising from breathing, snoring and body movements.
Dozee Early Warning System (DEWS): DEWS is an overall score for risk assessment of the physiological status of a person. It is a cumulative score of risk levels of physiological parameters like HR,RR and SPo2, which acts as an early predictor for possible physiological decline. Assessment of severity of of Acute-illness Detection of clinical deterioration Initiation of a timely and competent clinical response
Total 39 subjects were observed where 24 of the subjects were Male and 15 Female and the average duration of stay at the hospital was 5 days. There were 20 patients who had comorbid conditions like HYPOTHYROID, NHL,ASTHMA etc. 19 patients did not present with any co morbidities. The outcome of 10 patients was death and 29 patients were discharged after recovery, as reported by the healthcare professionals at the ward. The vitals of the subjects were continuously monitored by Dozee, a contactless remote patient monitoring system enabled with Dozee Early Warning System (DEWS) which reflects the overall patient condition based on the Respiration, Heart Rate and Spo2 of the patients.

Results:
The data from the continuous monitoring of the respiration rate, heart rate and oxygen saturation of the 39 patients were analysed for their duration of stay at the hospital. The DEWS score of the patients were also analysed

Conclusions:
It was concluded that continuous vitals monitoring of the patients and the resulting Dews scores were an indicator of the improving or deteriorating condition of the patients. The discharged patients showed a decrease in the DEWS score, especially Breathing DEWS before they recovered. However, the expired patients showed steady increase or a stagnant high Breathing dews until time of death