bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epicardial fat volume is related to the degree of cardiac allograft vasculopathy
Authors: Roest Stefan , Budde Ricardo P. J. , Brugts Jasper J. , von der Thüsen Jan , van Walsum Theo , Taverne Yannick J. H. J. , Zijlstra Felix , Bos Daniel , Manintveld Olivier C. 
Published: August 2022

Abstract
Objectives
Increasing evidence suggests a role for epicardial fat in the development of coronary artery disease in the general population. Heart transplantation patients are at increased risk of developing a specific form of coronary artery disease, cardiac allograft vasculopathy (CAV), which has far-reaching consequences in terms of morbidity and mortality. Until now, the role of epicardial fat volume (EFV) in the development of CAV remains unknown. Hence, we investigated the relationship between EFV and CAV as well as the influence of donor/recipient sex on EFV.

Methods
Adult heart transplant patients who underwent coronary computed tomography angiography (CCTA) for CAV screening who were four or more years post-HT were included. Using the CT examinations, we quantified the EFV and the degree of CAV. Ordinal and linear regression models were used to assess the association of EFV with CAV.

Results
In total, 149 (median age 44.5 years, 36% women) patients were included. The median time between HT and the CT scan was 11.0 (7.3–16.1) years. CAV grade 0, 1, 2 and 3 were seen in 85 (57%), 32 (22%), 14 (9%), and 18 (12%) patients, respectively. The median EFV was 208.4 (128.9–276.0) mL. Larger EFV were related to higher degrees of CAV (median of 164.7 to 290.6 mL for CAV grade 0 and 3, respectively, OR 5.23 (2.47–11.06), p < 0.001). Male recipients had significantly more EFV than female recipients irrespective of the donor sex (232.7 mL vs. 147.2 mL respectively, p < 0.001). Determinants for EFV were recipient sex, number of rejections, donor age, time between HT and CT scan, recipient BMI, and diabetes mellitus.

Conclusions
EFV was associated with higher degrees of CAV. The recipient sex influenced the EFV more than the donor sex.

Key Points
• Patients after heart transplantation have a high amount of epicardial fat while larger amounts of epicardial fat are related to higher grades of cardiac allograft vasculopathy.
• Determinants of higher epicardial fat volume included recipient sex, number of rejections, donor age, time between HT and CT scan, recipient BMI, and diabetes mellitus.
• Longitudinal studies are needed to further disentangle the role of epicardial fat in the development and progression of cardiac allograft vasculopathy.

Graphical abstract
Behavioural function and development of body-to-limb proportions and active movement ranges in three stick insect species
Authors: Dürr Volker , Mesanovic Ago 
Published: August 2022

Abstract
Overall body proportions and relative limb length are highly characteristic for most insect taxa. In case of the legs, limb length has mostly been discussed with regard to parameters of locomotor performance and, in particular cases, as an adaptation to environmental factors or to the mating system. Here, we compare three species of stick and leaf insects (Phasmatodea) that differ strongly in the length ratio between antennae and walking legs, with the antennae of Medauroidea extradentata being much shorter than its legs, nearly equal length of antennae and legs in Carausius morosus, and considerably longer antennae than front legs in Aretaon asperrimus. We show that that relative limb length is directly related to the near-range exploration effort, with complementary function of the antennae and front legs irrespective of their length ratio. Assuming that these inter-species differences hold for both sexes and all developmental stages, we further explore how relative limb length differs between sexes and how it changes throughout postembryonic development. We show that the pattern of limb-to-body proportions is species-characteristic despite sexual dimorphism, and find that the change in sexual dimorphism is strongest during the last two moults. Finally, we show that antennal growth rate is consistently higher than that of front legs, but differs categorically between the species investigated. Whereas antennal growth rate is constant in Carausius, the antennae grow exponentially in Medauroidea and with a sudden boost during the last moult in Aretaon.
Impact of the changing landscape of induction therapy prior to autologous stem cell transplantation in 540 newly diagnosed myeloma patients: a retrospective real-world study
Authors: Wang Song-Yau , Holzhey Tanja , Heyn Simone , Zehrfeld Thomas , Fricke Susann , Hoffmann Franz Albert , Becker Cornelia , Braunert Leanthe , Edelmann Thomas , Paulenz Inessa , Hitzschke Marcus , Flade Franziska , Schwarzer Andreas , Fenchel Klaus , Franke Georg-Nikolaus , Vucinic Vladan , Jentzsch Madlen , Schwind Sebastian , Hell Saskia , Backhaus Donata , Lange Thoralf , Niederwieser Dietger , Scholz Markus , Platzbecker Uwe , Pönisch Wolfram 
Published: August 2022

Abstract
Introduction
Autologous stem cell transplantation (ASCT) is the standard treatment for younger patients with newly diagnosed multiple myeloma (MM). However, due to restrictive exclusion criteria, more than half of eligible patients are usually excluded from transplant studies.

Methods
This retrospective monocentric analysis included 540 patients with MM who received an ASCT between 1996 and 2019.

Results
Up to 2005, induction therapy consisted mainly of conventional chemotherapies, e.g. vincristine/doxorubicin/dexamethasone (VAD). In the following years, the triple-combinations based on bortezomib coupled with doxorubicin/dexamethasone (PAD), melphalan/prednisolone (VMP), cyclophposphamide/dexamethasone (VCD) or bendamustine/prednisolone (BPV) became the most popular treatment options. A progressive improvement in PFS was observed in patients treated with the two current induction therapies BPV (47 months) or VCD (54 months) compared to VAD (35 months, p < 0.03), PAD (39 months, p < 0.01 and VMP (36 months, p < 0.01). However, there was no significant difference in median OS (VAD 78, PAD 74, VMP 72, BPV 80 months and VCD not reached). In our analysis, we also included 139 patients who do fulfill at least one of the exclusion criteria for most phase 3 transplant studies (POEMS/amyloidosis/plasma cell leukemia, eGFR < 40 mL/min, severe cardiac dysfunction or poor general condition). Outcome for these patients was not significantly inferior compared to patients who met the inclusion criteria for most of the transplant studies with PFS of 36 vs 41 months (p = 0.78) and OS of 78 vs 79 months (p = 0.34).

Conclusions
Our real-world data in unselected pts also stress the substantial value of ASCT during the first-line treatment of younger MM pts.
One hundred years of advances in volcano seismology and acoustics
Authors: Matoza Robin S. , Roman Diana C. 
Published: August 2022

AbstractSince the 1919 foundation of the International Association of Volcanology and Chemistry of the Earth’s Interior (IAVCEI), the fields of volcano seismology and acoustics have seen dramatic advances in instrumentation and techniques, and have undergone paradigm shifts in the understanding of volcanic seismo-acoustic source processes and internal volcanic structure. Some early twentieth-century volcanological studies gave equal emphasis to barograph (infrasound and acoustic-gravity wave) and seismograph observations, but volcano seismology rapidly outpaced volcano acoustics and became the standard geophysical volcano-monitoring tool. Permanent seismic networks were established on volcanoes (for example) in Japan, the Philippines, Russia, and Hawai‘i by the 1950s, and in Alaska by the 1970s. Large eruptions with societal consequences generally catalyzed the implementation of new seismic instrumentation and led to operationalization of research methodologies. Seismic data now form the backbone of most local ground-based volcano monitoring networks worldwide and play a critical role in understanding how volcanoes work. The computer revolution enabled increasingly sophisticated data processing and source modeling, and facilitated the transition to continuous digital waveform recording by about the 1990s. In the 1970s and 1980s, quantitative models emerged for long-period (LP) event and tremor sources in fluid-driven cracks and conduits. Beginning in the 1970s, early models for volcano-tectonic (VT) earthquake swarms invoking crack tip stresses expanded to involve stress transfer into the wall rocks of pressurized dikes. The first deployments of broadband seismic instrumentation and infrasound sensors on volcanoes in the 1990s led to discoveries of new signals and phenomena. Rapid advances in infrasound technology; signal processing, analysis, and inversion; and atmospheric propagation modeling have now established the role of regional (15–250 km) and remote (> 250 km) ground-based acoustic systems in volcano monitoring. Long-term records of volcano-seismic unrest through full eruptive cycles are providing insight into magma transport and eruption processes and increasingly sophisticated forecasts. Laboratory and numerical experiments are elucidating seismo-acoustic source processes in volcanic fluid systems, and are observationally constrained by increasingly dense geophysical field deployments taking advantage of low-power, compact broadband, and nodal technologies. In recent years, the fields of volcano geodesy, seismology, and acoustics (both atmospheric infrasound and ocean hydroacoustics) are increasingly merging. Despite vast progress over the past century, major questions remain regarding source processes, patterns of volcano-seismic unrest, internal volcanic structure, and the relationship between seismic unrest and volcanic processes.
Self-Stabilizing and Private Distributed Shared Atomic Memory in Seldomly Fair Message Passing Networks
Authors: Dolev Shlomi , Petig Thomas , Schiller Elad M. 
Published: August 2022

AbstractWe study the problem of privately emulating shared memory in message-passing networks. The system includes clients that store and retrieve replicated information onNservers, out of whichearedata-corrupting malicious. When a client accesses a data-corrupting malicious server, the data field of that server response might be different from the value it originally stored. However, all other control variables in the server reply and protocol actions are according to the server algorithm. For the coded atomic storage algorithms by Cadambe et al., we present an enhancement that ensures no information leakage and data-corrupting malicious fault-tolerance. We also consider recovery after the occurrence of transient faults that violate the assumptions according to which the system was designed to operate. After their last occurrence, transient faults leave the system in an arbitrary state (while the program code stays intact). We present a self-stabilizing algorithm, which recovers after the occurrence of transient faults. This addition to Cadambe et al. considers asynchronous settings as long as no transient faults occur. The recovery from transient faults that bring the system counters (close) to their maximal values may include the use of a global reset procedure, which requires the system run to be controlled by a fair scheduler. After the recovery period, the safety properties are provided for asynchronous system runs that are not necessarily controlled by fair schedulers. Since the recovery period is bounded and the occurrence of transient faults is extremely rare, we call this design criteria self-stabilization in the presence of seldom fairness. Our self-stabilizing algorithm uses a bounded amount of storage during asynchronous executions (that are not necessarily controlled by fair schedulers). To the best of our knowledge, we are the first to address privacy, data-corrupting malicious behavior, and self-stabilization in the context of emulating atomic shared memory in message-passing systems.
Remote sensing techniques and geochemical constraints on the formation of the Wadi El-Hima mineralized granites, Egypt: new insights into the genesis and accumulation of garnets
Authors: Khedr Mohamed Zaki , Abo Khashaba Saif M. , El-Shibiny N. H. , El-Arafy Reda A. , Takazawa Eiichi , Azer Mokhles K. , Palin Richard. M. 
Published: August 2022

AbstractThe Wadi El-Hima Neoproterozoic I- and A-type granites in the Southern Eastern Desert of Egypt are rich in garnets (up to 30 vol%) and are cut by NW–SE strike-slip faults, as confirmed from structure lineament extraction maps. These mineralized granites and garnet mineralization zones can be successfully discriminated using remote sensing techniques. Spectral angle mapper and matched filtering techniques are highly effective for mapping garnet-rich zones and show that the highest garnet concentrations occur along the intrusive contact zone of NW–SE striking faults. El-Hima granites have high SiO2(73.5–75.1 wt%), Al2O3(13.4–15.3 wt%) and total alkali (6.7–8.7 wt%) contents, suggesting that they were sourced from peraluminous (A/CNK > 1) parental magmas. Garnet-bearing trondhjemites are metasomatic in origin and formed after I-type tonalite-granodiorites, which originated in a volcanic arc tectonic setting. Garnet-rich syenogranites and alkali-feldspar granites are both post-collisional A-type granites: the syenogranites formed from peraluminous magmas generated by partial melting of lower crustal tonalite and metasedimentary protoliths during lithospheric delamination, and the alkali-feldspar granites crystallized from highly fractionated, felsic and alkali-rich peraluminous magmas in the upper crust. Garnets in El-Hima mineralized granites occur in three forms: (1) subhedral disseminated crystals, (2) vein-type crystals, and (3) aggregated subhedral crystals, reflecting different mechanisms of accumulation. All are dominantly almandine in composition (Alm76Sps10Prp7Grs6Adr1) and have high average concentrations of heavy rare earth elements (HREE) (ΣHREE = 1636 ppm), Y = (3394 ppm), Zn (325 ppm), Li (39.17 ppm) and Ga (34.94 ppm). Garnet REE patterns show strong negative Eu anomalies with HREE enriched relative to LREE, indicating a magmatic origin. These magmatic garnets are late-stage crystallization products of Al-rich hydrous magmas, and formed at low temperature (680–730 °C) and pressure (2.1–2.93 kbar) conditions in the upper continental crust. Peculiar garnet concentrations in syenogranites near and along contact zones with alkali feldspar granites are related to peraluminous parent hydrous magma compositions. These garnets formed by in situ crystallization from A-type granite melts, alongside accumulation of residual garnets left behind after partial melting of the host garnet-rich granites along the intrusive contact. Magmatic-fluid flow along the NW–SE striking fault of Najd system enhanced garnet accumulation in melts, which formed clots and veins of garnet.
Does surgical plethysmographic index-guided analgesia affect opioid requirement and extubation time? A systematic review and meta-analysis
Authors: Hung Shao-Chi , Hsu Wei-Ti , Fu Chi-Lin , Lai Yu-Wen , Shen Mei-Ling , Chen Kuen-Bao 
Published: August 2022

Abstract
Purpose
This meta-analysis of all relevant clinical trials investigated surgical plethysmographic index (SPI)-guided analgesia’s efficacy under general anesthesia for perioperative opioid requirement and emergence time after anesthesia.

Methods
PubMed, Embase, Web of Science, and Cochrane Library were searched up to January 2022 to identify clinical trials comparing SPI-guided and conventional clinical practice for patients who underwent general anesthesia. With the random-effects model, we compared intraoperative opioid consumption, emergence time, postoperative pain, analgesia requirement, and incidence of postoperative nausea and vomiting (PONV).

Results
Thirteen randomized controlled trials (RCTs) (n = 1314) met our selection criteria. The overall pooled effect sizes of all RCTs indicated that SPI-guided analgesia could not significantly reduce opioid consumption during general anesthesia. SPI-guided analgesia accompanied with hypnosis monitoring could decrease intraoperative opioid consumption (standardized mean difference [SMD] − 0.31, 95% confidence interval [CI] − 0.63 to 0.00) more effectively than SPI without hypnosis monitoring (SMD 1.03, 95% CI 0.53–1.53), showing a significant difference (p < 0.001). SPI-guided analgesia could significantly shorten the emergence time, whether assessed by extubation time (SMD − 0.36, 95% CI − 0.70 to − 0.03, p < 0.05, I2 = 67%) or eye-opening time (SMD − 0.40, 95% CI − 0.63 to − 0.18, p < 0.001, I2 = 54%). SPI-guided analgesia did not affect the incidence of PONV, postoperative pain, and analgesia management.

Conclusion
SPI-guided analgesia under general anesthesia could enhance recovery after surgery without increasing the postoperative complication risk. However, it did not affect intraoperative opioid requirement. Notably, SPI-guided analgesia with hypnosis monitoring could effectively reduce intraoperative opioid requirement.
A novel approach to construct self-assembled 3D MEMS arrays
Authors: Akhundzada Sapida , Yang Xiaohui , Fiedler Johannes , Käkel Eireen , Al-Qargholi Basim , Buhmann Stefan , Ehresmann Arno , Hillmer Hartmut 
Published: August 2022

AbstractThe paper presents the design and technological fabrication process of Yin or Yang-shaped, micron-sized electromechanical system (MEMS) elements displaying asymmetric hollow cylinders with two different curvatures of the cylinder shell. By adapting the process steps, two neighboring shutter MEMS elements can either be attached to each other to create asymmetric hollow cylinders or remain disconnected to form curled cylindrical or ellipsoidal tubes or tube fractions. A novel 3D self-organization process has been developed to connect two neighboring shutter elements, exploiting surface tension forces via a sequential drying process. The process conditions have been analyzed and optimized to fabricate the two different geometries of the MEMS elements. The resulting MEMS system elements were characterized by focused ion beam and scanning electron microscopy. The contribution of Casimir force, van der Waals force, and other physical interfacial forces are discussed in the formation of the asymmetric hollow cylinders.
Microscopic and Acoustic Interpretations of the Physics of Rock Burst and the Difference in Fracturing Patterns in Class I and Class II Rocks
Authors: Wan Wenkai , Li Charlie C. 
Published: August 2022

AbstractThe progressive microcracking processes in a burst-prone Class II rock, Kuru granite, and a non-burst-prone Class I rock, Fauske marble were investigated, aiming to reveal the physics of rock burst and the difference in burst-proneness in Class I and Class II rocks. The cylindrical rock specimens of Kuru granite and Fauske marble were uniaxially loaded to various levels in both pre- and post-peak stages, which was monitored by Acoustic emission technique. After that, the thin sections parallel and perpendicular to the loading direction were prepared from each unloaded specimen. The observed intergranular and intragranular cracks in thin sections were quantitatively analyzed in their length, width and orientation as well as the fracturing modes. It was found that extensional intergranular cracking dominated the damaging process in Kuru granite in the pre-peak stage. In the post-peak stage, both intergranular and intragranular cracks increased abruptly. The granite specimen finally failed in splitting. Intragranular shear cracking in calcite dominated the damaging process in Fauske marble. A number of shear fractures formed in the marble and finally the marble failed along a shear fracture zone. It was deduced that, under low confining stress, the fracturing process in Kuru granite of Class II was dominated by extensional fracturing in the direction of σ1, which dissipated a relatively small portion of the strain energy in the rock and the remaining energy was released for rock ejection. The fracturing in Fauske marble of Class I was dominated by intragranular shear cracking, which dissipated the entire strain energy.
Crowd-based requirements elicitation via pull feedback: method and case studies
Authors: Wouters Jelle , Menkveld Abel , Brinkkemper Sjaak , Dalpiaz Fabiano 
Published: August 2022

AbstractCrowd-based Requirements Engineering (CrowdRE) promotes the active involvement of a large number of stakeholders in RE activities. A prominent strand of CrowdRE research concerns the creation and use of online platforms for a crowd of stakeholders to formulate ideas, which serve as an additional input for requirements elicitation. Most of the reported case studies are of small size, and they analyze the size of the crowd, rather than the quality of the collected ideas. By means of an iterative design that includes three case studies conducted at two organizations, we present the CREUS method for crowd-based elicitation via user stories. Besides reporting the details of these case studies and quantitative results on the number of participants, ideas, votes, etc., a key contribution of this paper is a qualitative analysis of the elicited ideas. To analyze the quality of the user stories, we apply criteria from the Quality User Story framework, we calculate automated text readability metrics, and we check for the presence of vague words. We also study whether the user stories can be linked to software qualities, and the specificity of the ideas. Based on the results, we distill six key findings regarding CREUS and, more generally, for CrowdRE via pull feedback.
Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis
Authors: Sari Aysegul , Dogan Serdar , Nibali Luigi , Koseoglu Serhat 
Published: August 2022

AbstractObjectivesIL-23p19/Ebi3 (IL-39) was described as a new IL-12 family member. The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1β and periostin.Materials and methodsSixty-six adult patients were included in the study. The study design was comprised of three groups, each containing 22 individuals: the periodontally healthy (PH), gingivitis (G), and periodontitis (P) groups. The clinical periodontal parameters were recorded and GCF samples were collected from the participants. GCF interleukin (IL)-39, IL-1β, and periostin levels were examined using the enzyme-linked immunosorbent assay.ResultsGCF IL‑1β, periostin, and IL-39 levels were higher in the P and G groups than in the PH group (p < 0.001). Positive correlations were detected between all GCF biochemical parameters and clinical periodontal parameters (p < 0.05). In the multivariate generalized linear regression analysis, the P (β = 37.6, 95% CI = 22.9–52.4) and G (β = 28.4, 95% CI = 15.8–41) groups were associated with GCF IL-39 levels (p < 0.001).ConclusionIL-39 levels were elevated in the presence of periodontal disease paralleling the increase in IL‑1β and periostin levels. IL-39 may have a role in the periodontal inflammation process.Statement of clinical relevanceIL-39, a new cytokine from the IL-12 family, can be a possible predictor marker of periodontal diseases.