bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing and Delineation of Groundwater Recharge Areas in Coastal Arid Area in Tunisia Using GIS, Remote Sensing Techniques and Self-organizing Map
Authors: Abdelkarim Bilel , Telahigue Faten , Agoubi Belgacem 
Published: January 2022

Abstract
In Gabès region (southeastern Tunisia), given the semi-arid to arid climate conditions, groundwater is an essential resource to supply the growth needs of the socio-economic development. To ensure sustainable development and preserve water resources, a careful estimation of the present day recharge amount and the delineation of the potential zones of rainfall precipitation are of required for an accurate evaluation of regional water balance. In this context, this study aims to a preliminary assessment of groundwater recharge in Gabes basin in regard to the delineation of the potential recharge areas of phreatic aquifers. Thus, a geological and hydrogeological collected database coupled with remote sensing techniques (RST) were used for the determination of the lateral variation of recharging zone ,Treatment by ArcGIS and Matlab softwares and Kohonen self-organizing maps (K-SOM) approaches.The obtained results indicate that five recharge potential areas have been identified and classified as 27% very low, 23% low, 40% moderate recharge, 7% good and 3 % very good potential recharge located principally on southern part of the study region .This distribution is controlled principally by the geomorphological, geologic, and hydrogeologic features of the region . Reasonable management strategies based on a perennial exploitation of these low renewable resources are required to optimize the water dependent socio-economic development. The estimated groundwater potential recharge of Gabès aquifer system using K-SOM and RST is of 11.4 Mm3.y-1. This recharging rate is very low it present 7% of the total rain, thus it must be ameliorated. K-SOM and RST approach is a useful method for groundwater potential recharge mapping and is a helpful of wells establishment and groundwater sustainable management.an isotopic analyses is recommended to ameliorate the decision maker to establish the adequate strategy.
Repeated Ct-based Hounsfield Unit Measurements as a Proxy Measure of Intercorporal Bone Graft Remodelling Towards Spinal Fusion; a Feasibility Study.
Authors: Reijmer JFH , Jong LD , Kruyt M. C. , Gorp MJ van , Susante JLC van 
Published: January 2022

Abstract
Background: There is a lack of knowledge about the biological process of intercorporal bone graft remodelling towards successful lumbar spine fusion with bridging vital bone between two adjacent vertebrae. Hounsfield Units (HU) highly correlate with Bone Mineral Density (BMD) and changes in HU may be valuable as proxy measure to monitor ongoing fusion. The aims of this study were to explore the feasibility to quantify BMD changes in the intercorporal bone graft after spinal fusion on consecutive CT-scans, and to explore whether trends in the individual changes in HU over time may serve as a proxy measure for successful fusion or non-fusion.Methods: A retrospective case series was conducted using available one-year and two-year CT-data from patients after posterior lumbar interbody fusion surgery. First, a standardized measuring procedure was developed, incorporating internal phantomless calibration, to establish the HU values of the grafted region of interest using consecutive CT-slices. Subsequently, changes in the participants’ bone graft HU over time between their first and second year after surgery were explored.Results: Between one and two years after surgery, seven out of nine (78%) participants showed an increase in their bone grafts’ HU, ranging from 3% to 41%. In two participants HU-values decreased 14% and 32%, respectively. The intraobserver reliability of the HU measuring procedure was excellent (ICC 0.93 (95% confidence interval 0.91 to 0.95)).Conclusion: The majority (78%) of participants in the current study showed increases in their bone graft HU, which suggests ongoing bone graft remodelling towards lumbar fusion. This result corresponds with the established percentages of achieved rigid bony fusion after lumbar spinal fusion surgery reported in the literature. Thus, prospective follow-up of CT-based HU measurements may have potential as diagnostic measure to monitor bone graft remodelling in time and trends may predict successful fusion or non-fusion. The measurement procedure developed in this study, using internal phantomless calibration, showed excellent intraobserver reliability and merits further study in larger patient numbers.
Spatial disparities and associated factors of Under-five diarrhea disease in Ilubabor Zone, Oromia Regional State, Ethiopia
Authors: Gelan Ebsa , Worku Mulata , Misganaw Azmeraw , Jabessa Dabala 
Published: January 2022

Abstract
Diarrhea is commonly a sign of an infection in the intestinal tract that is caused by different bacteria, virus and parasitic entities. It is one of the leading causes of child mortality worldwide, especially in sub-Saharan Africa countries including Ethiopia. The main objective of this study was to identify spatial disparities and associated factors of under- five diarrhea disease in Ilubabor zone, Oromia regional state, Ethiopia. The study has been conducted in Ilu Aba Bor zone of entire districts and the data is basically both primary and secondary which were obtained from each woreda health office of Ilu Aba Bor zone and corresponding mother or care givers of sampled child. Spatial disparities of under-five diarrhea were identified using global and local measures of spatial autocorrelation. Geo-additive regression model was used to identify the spatial disparities and associated factors of under-five diarrheal disease. The value of global and local measures of spatial autocorrelation shows that under-five diarrheal disease varies according to geographical location and shows significant positive spatial autocorrelation. The results of Geo-additive regression model showed that statistically significant relationship between under-five diarrhea disease and independent variables .There is evidence of significant under-five diarrheal disease clustering in Ilu Aba Bor zone, southwest Ethiopia. Model based data analysis showed that there is significant relationship between Under-five diarrhea and covariates (mother’s age, mother’s education, source of drinking water, quality of toilet facility, DPT 3 vaccination, Polio 3 vaccination and household wealth index.).
Effectiveness of Intraoperative Cell Salvage Combined with a Modified Leucocyte Depletion Filter in Metastatic Spine Tumour Surgery
Authors: Zong Ya-nan , Xu Chuan-ya , Gong Yue-qing , Zhang Xiao-qing , Zeng Hong , Liu Chang , Zhang Bin , Xue Li-xiang , Guo Xiang-yang , Wei Feng , Li Yi 
Published: January 2022

Abstract
Background

To compare the effectiveness of intraoperative cell salvage (IOCS) combined with a modified leucocyte depletion filter (MLDF) with IOCS combined with a regular leucocyte depletion filter (RLDF) in eliminating tumour cells from blood salvage during metastatic spine tumour surgery (MSTS).
Methods

Patients with a known primary epithelial tumour who underwent MSTS were recruited for this study. Blood samples were collected in 5 stages: from the patients’ vein before anaesthesia induction (S1), from the operative field during tumour manipulation (S2), and from the operative blood after IOCS processing (S3) and after IOCS+RLDF (S4) and IOCS+MLDF (S5) processing. The polyploids of tumour cells in the blood samples were collected and counted with immunomagnetic separation enrichment and fluorescence in situ hybridization.
Results

We recruited 20 patients. Tumour cells were detected in 14 patients (70%) in S1, 16 patients (80%) in S2, 13 patients (65%) in S3, and 12 patients (60%) in S4. MLDF was added in 8 patients. Tumour cells were detected in only 1 of 8 patients in S5 (12.5%). There were significantly fewer tumour cells in the samples collected after MLDF processing (S5) than in the samples collected after RLDF (S4) and around the tumour (S2) (P = 0.016 and P = 0.039, respectively). Although no significant difference was observed between S4 and S1, a downward trend was observed after IOCS+RLDF processing.
Conclusions

Tumour cells could be removed by IOCS combined with RLDF from blood salvaged during MSTS, but residual tumour cells remained. The findings support the notion that MLDF eliminates tumour cells more effectively than RLDF. Hence, this technique can be applied to MSTS.
Trial Registration

ChiCTR1800016162 Chinese Clinical Trial Registry http://www.chictr.org.cn/showproj.aspx?proj=27263
Genome-based Classification of Streptomyces Pinistramenti sp. nov., a Novel Actinomycete Isolated From a Pine Forest Soil in Poland With a Focus on Its Biotechnological and Ecological Properties
Authors: Śwecimska Magdalena , Golinska Patrycja , Goodfellow Michael 
Published: January 2022

Abstract
A genomic-based polyphasic study was undertaken to establish the taxonomic status and biotechnological and ecological potential of a Streptomyces strain, isolate SF28T, that was recovered from the litter layer in a polish Pinus sylvestris forest. The isolate had morphological characteristics and chemotaxonomic properties consistent with its classification in the genus Streptomyces. It formed long straight chains of spores with smooth surfaces, contained LL-diaminopimelic acid and glucose and ribose in whole-organism hydrolysates, produced major proportions of straight, iso- and anteiso- fatty acids, hexa- and octa-hydrogenated menaquinones with nine isoprenoid units and had a polar lipid pattern composed of diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylmethylethanolamine, glycophospholipids and three uncharacterized components. Phylogenetic trees prepared using 16S rRNA gene and multilocus gene sequences of conserved housekeeping genes showed that the isolate formed a branch that was loosely associated with the type strains of several validly published Streptomyces species. A draft genome generated for the isolate was rich in natural product-biosynthetic gene clusters with the potential to produce new specialised metabolites, notably antibiotics, and stress related genes which provide an insight into how they may have adapted to the harsh conditions that prevail in acidic forest soils. A phylogenomic tree based on the genomes of the isolate and its phylogenetic neighbours confirmed that it formed a distinct lineage well separated from its closest evolutionary relatives. The isolate shared low average nucleotide index and digital DNA:DNA hybridization values with its phylogenomic neighbours and was also distinguished from them using a combination of cultural and micromorphological properties. Given this wealth of taxonomic data it is proposed that isolate SF28T (=DSM 113360T=PCM 3163T) be classified in the genus Streptomyces as Streptomyces pinistramenti sp. nov. The isolate showed pronounced antimicrobial activity, especially against fungal plant pathogens.
Sexual Satisfaction and Sexual Behaviors During the Covid-19 Pandemic: Results From the International Sexual Health and Reproductive (I-SHARE) Health Survey in Luxembourg
Authors: Fischer Vinicius Jobim , Gómez-Bravo Raquel , Brunnet Alice Einloft , Michielsen Kristien , Tucker Joseph D. , Campbell Linda , Vögele Claus 
Published: January 2022

Abstract
Aim: To identify the impact of COVID-19 measures on sexual behaviors and sexual satisfaction in Luxembourg residents. Methods: We conducted a cross-sectional online survey of adults (> 18 years of age) residing in Luxembourg, while COVID-19 restrictions were in place. The survey was available in four languages (French, German, English and Portuguese). Survey questions focused on masturbation, cuddling, condom use, sex frequency, sexting, cybersex, watching porn, and sexual satisfaction.Results: 557 volunteers completed the survey (35.5% men, 64.3% women). Sexual problems increased during the COVID-19 measures while sexual satisfaction decreased compared to prior the COVID-19 measures (assessed retrospectively). Factors associated with increased odds of sexual satisfaction were: having a steady relationship before COVID-19 restrictions, engaging in sexting, reporting good mental health and not altering alcohol intake.Conclusions: The context of the COVID-19 pandemic and the measures implemented in Luxembourg affected sexual behaviors and sexual satisfaction. Sexual and reproductive health care centers and health professionals in general should take these results into consideration when providing care. Recommendations on the importance of sexual health for general wellbeing and behaviors associated with sexual satisfaction should be offered and possibilities to experience sexuality while reducing contamination risks be discussed.
Pregnancy Outcomes of Non-Visualization of The Foetal Gallbladder From A Chinese Tertiary Single Centre And Literature Review
Authors: Zhang Huijing , Zhu Xiaoying , Kang Jinling , Yang Huixia , Sun Yu 
Published: January 2022

Abstract
Objection To explore the clinical features and prognosis of non-visualization of fetal gallbladder (NVFGB). Methods 65 cases diagnosed of NVFGB in the Peking University First Hospital was collected retrospectively from January, 2019 to December, 2020. Results 49 cases were successfully followed up. Among them, the gallbladder of 21 fetuses (42.9%) was visible later, either in the later pregnancy or after birth. In the rest 28 cases (57.1%), the gallbladders were not seen during the whole pregnancy. 11 of 28 fetuses (39.3%) with NVFGB were complicated with other structure anomaly. In the remaining 17 cases of isolated NVFGB (60.7%), one case was diagnosed of congenital biliary atresia, 3 cases of small gallbladder, 1 case of gallstone and one case of irregular size of gallbladder. There are 9 cases who underwent prenatal diagnosis, with 4 cases of abnormal result. Conclusion Prenatal ultrasound plays a role in the early recognize of abnormal gallbladder, which will improve the postnatal prognosis.
Neovascular Glaucoma Associated with Chronic Rhegmatogenous Retinal Detachment
Authors: Kim Dong Ik , Woo Se Joon 
Published: January 2022

Abstract
Background
To demonstrate the clinical features and natural course of chronic retinal detachment associated neovascular glaucoma.
Methods
Ten patients, diagnosed with chronic retinal detachment-associated neovascular glaucoma during 2007-2016 were retrospectively investigated. Besides chronic retinal detachment, no patients had any neovascular glaucoma-predisposing conditions, such as carotid artery disease. Retinal perfusion status was evaluated from postoperative visual acuity, intraocular pressures, ocular examination findings, and fluorescein angiography images.
Results
The mean age of patients was 57.5 (range: 22-78) years. Complete retinal reattachment was achieved in 3 eyes, while partial or total chronic retinal detachment persisted in 7 eyes. Wide-angle fundus fluorescein angiography revealed peripheral retinal capillary obstruction and severe non-perfusion. Neovascular glaucoma developed 213.4 months (17-634 months) after retinal detachment. Three eyes received Ahmed valve implantation, while 5 eyes received intravitreal bevacizumab injection. Intraocular pressure was controlled in 10 eyes. Two eyes developed phthisis bulbi during follow-up.
Conclusions
In eyes with a chronic retinal detachment history, iris neovascularization and neovascular glaucoma can develop due to retinal capillary obstruction and chronic retinal ischemia, even after achieving retinal reattachment. We suggest routine follow-up examinations for patients with chronic retinal detachment, particularly for eyes with retinal non-perfusion, as detected on fundus fluorescein angiography.
Molecular Docking and Molecular Dynamics Studies of Role of Anti-Allergic Medicines as Inhibitors Against Covid-19
Authors: Si Mrinal Kanti 
Published: January 2022

Abstract
The 2019-nCoV virus is a human-infectious coronavirus (CoV). Very few treatment options are available to healthcare professionals who are fighting this outbreak at the front. The main warning symptoms of COVID-19, the disease caused by the new coronavirus, are fever, fatigue, and a dry cough, sometimes it also causes cold-like symptoms like a runny nose which are sometimes similar to symptoms of allergies and sometimes difficult to differentiate between COVID-19 and allergies. The anti-allergic drug molecules can behave as good inhibitor against COVID-19. Molecular docking studies have been performed to examine the inhibitor properties of anti-allergic molecules against Covid-19. The searching of better inhibitors have been examined interns of various non-covalent interactions like hydrogen bond, halogen bond, vander waal’s interactions, alkyl-πand π-π interactions between small molecules (Anti-allergic medicines) with main protease of Covid-19 using molecular docking and Molecular Dynamics simulation which reveals that astemizole is best inhibitor among ten Anti-allergic drug molecules.
How Accurate are Geriatricians’ Fall Predictions?
Authors: Wilbur Jason , Jogerst Gerald , Butler Nicholas , Xu Yinghui 
Published: January 2022

Abstract
Background: Older patients are at increased risk of falling and of serious morbidity and mortality resulting from falls. The ability to accurately identify older patients at increased fall risk affords the opportunity to implement interventions to reduce morbidity and mortality. Geriatricians are trained to assess older patients for fall risk. If geriatricians can accurately predict fallers (as opposed to evaluating for individual risk factors for falling), more aggressive and earlier interventions could be employed to reduce falls in older adult fallers. However, there is paucity of knowledge regarding the accuracy of geriatrician fall risk predictions. This study aims to determine the accuracy of geriatricians in predicting falls. Methods: Between October 2018 and November 2019, a convenience sample of 100 subjects was recruited from an academic geriatric clinic population seeking routine medical care. Subjects performed a series of gait and balance assessments, answered the Stay Independent Brochure and were surveyed about fall incidence 6-12 months after study entry. Five geriatricians, blinded to subjects and fall outcomes, were provided the subjects’ data and asked to categorize each as a faller or non-faller. No requirements were imposed on the geriatricians’ use of the available data. These predictions were compared to predictions of an examining geriatrician who performed the assessments and to fall outcomes reported by subjects. Results: Kappa values for the 5 geriatricians who used all the available data to classify participants as fallers or non-fallers compared with the examining geriatrician were 0.42 to 0.59, indicating moderate agreement. Compared to screening tools’ mean accuracy of 66.6% (59.6-73.0%), the 5 geriatricians had a mean accuracy for fall prediction of 67.4% (57.3-71.9%).Conclusions: This study adds to the scant knowledge available in the medical literature regarding the abilities of geriatricians to accurately predict falls in older patients. Studies are needed to characterize how geriatrician assessments of fall risk compare to standardized assessment tools.
Emotion Dysregulation and Heart Rate variability Improve in US Veterans Undergoing Treatment for Posttraumatic Stress Disorder: Secondary Exploratory Analyses from a Randomised Controlled Trial
Authors: Mathersul Danielle C. , Dixit Kamini , Schulz-Heik R. Jay , Avery Timothy J. , Zeitzer Jamie M. , Bayley Peter J. 
Published: January 2022

Abstract
Background.
Emotion regulation (ER) is a key process underlying posttraumatic stress disorder (PTSD), yet, little is known about how ER changes with PTSD treatment. Understanding these effects may shed light on treatment processes.
Methods.
We recently completed a randomised controlled trial demonstrating that a breathing-based yoga practice (Sudarshan kriya yoga; SKY) was not clinically inferior to cognitive processing therapy (CPT) across symptoms of PTSD, depression, or negative affect. Here, in secondary exploratory analyses (intent-to-treat N=85; per protocol N=59), we examined whether self-reported ER (Difficulties in Emotion Regulation Scale; DERS) and physiological ER (heart rate variability; HRV) improved with treatment for clinically significant PTSD symptoms among US Veterans.
Results.
DERS-Total and all six subscales improved with small-to-moderate effect sizes (d = .24-.66) following CPT or SKY, with no differences between treatment groups. Following SKY (but not CPT), HR max–min (average difference between maximum and minimum beats per minute), normalised HF-HRV (high frequency power), and LF/HF (low-to-high frequency) ratio improved (moved towards a healthier profile; d = .32-.55).
Conclusions.
To our knowledge, this is the first study to demonstrate that a breathing-based yoga (SKY) improved both voluntary/intentional and automatic/physiological ER. In contrast, trauma-focused therapy (CPT) only reliably improved self-reported ER. Findings have implications for PTSD treatment and interventions for emotional disorders more broadly.
Trial registration:
Secondary analyses of ClinicalTrials.gov NCT02366403.
Ticagrelor Versus Clopidogrel in The Treatment of Elderly Chinese Chronic Total Occlusion Patients Undergoing PCI
Authors: Han Peng , Liang Ying , Xu Suining , Zhao Shuai , Chen Yan , Wang Ziwei , Chen Yuhao , Zhu Boda , Sha Zhilin , Shen Anxin , Tao Feng , Wang Qin , Wang Qiong , Chen Genrui , Tan Zhijun , Yang Li , Gao Haokao , Li Chengxiang , Lian Kun 
Published: January 2022

Abstract
Background: Taking thrombosis and bleeding risks into consideration, little real world study data is available to dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in elderly Chinese chronic total occlusion (CTO) patients. Methods: We assigned 504 CTO patients aged ≥75 years who successfully underwent PCI from December 2009 to May 2020. The patients were randomized to Clopidogrel and Ticagrelor group and received DAPT for up to 12 months. Efficacy endpoints were evaluated by major adverse cardiac events (MACE) consisting of all-cause death, nonfatal myocardial infarction (MI) and clinically driven revascularization. The safety endpoints were recorded as the incidence of Bleeding Academic Research Consortium (BARC) bleeding. Results: Patients in Clopidogrel group were older, they had a higher percentage of BMI, diastolic blood pressure and HDL-C than those in Ticagrelor group. Clopidogrel group had a lower percentage of hyperlipidemia, prior PCI, glucose, TG and LDL-C. No significant difference was found as to the Angiographic and procedural characteristics (P＞0.05 for all). After 12 months' follow-up, the incidence of MACE (12.19% vs. 11.04%, P=0.763) and bleeding (9.38% vs. 13.64%, P=0.205) had no significant difference. After clinical characteristics balanced matching by IPTWs model, we found that Ticagrelor had an unfavorable effect on reducing the incidence of bleeding with the IPTWs model (IPTW-OR, 1.81, 95% CI: 1.18-2.76, P=0.006). Conclusions: This clinical study demonstrated that Clopidogrel should be recommended to elderly CTO patients after PCI, especially those with a high bleeding risk. Trial registration: The study protocol was approved by the Ethics Committee of Air Force Medical University (KY20172019-1).