bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Search for Optimal Oxygen Saturation Targets in Sepsis Patients: a retrospective study
Authors: Wang Kaijin , Hao Qin , Hu Zhong , Wang Jin , Zheng Juan , wang yang 
Published: December 2022

Abstract
Background
Hypoxemia or hyperoxia oxygenation might increase in-hospital mortality in patients with sepsis. However, the optimal oxygenation target remained unknown. We performed a study to explore and validate the optimal oxygen saturation targets in sepsis patients.
Methods
Medical records of sepsis patients from 2008 to 2019 were retrieved from the Medical Information Mart for Intensive Care (MIMIC)-IV database. A generalized additive model (GAM) was established to comprehensively analyze the U-shaped nonlinear relationship between in-hospital mortality and time-weighted average (TWA)-SpO2 during oxygenation. The lowest and flattest area was identified as the optimal oxygenation target. A logistic regression was utilized to verify the optimal oxygenation target. Finally, a mediation analysis was adopted to estimate the direct effect of the TWA-SpO2 level by excluding the indirect effect of the fraction of inspired O2(FiO2).
Results
3800 sepsis patients with 630,704 SpO2 records were enrolled in our study, among whom 705 (18.5%) passed away at hospital discharge. The median age of the patients was 54.31 [52.22, 76.66] years, and 2326 (61.21%) were male patients. The GAM analysis demonstrated a U-shaped nonlinear relationship between TWA-SpO2 and in-hospital mortality during oxygenation. The SpO2 interval corresponding to the curve's lowest region of in-hospital mortality was 95%~98%. In accordance with the relationship between the TWA-SpO2 and the target interval range, the patients were segregated into hypoxemia, hyperoxia, and optimal oxygenation group, respectively. The multivariate logistic regression results also presented that the in-hospital mortality risk in the hypoxia oxygenation groups increased by 60.4% (OR=1.60, 95%CI 1.23~2.09, P<0.001), while patients in the hyperoxia oxygenation group also increased by 61.3% (OR=1.61, 95 %CI: 1.26-2.06, P<0.001), by adopting the sepsis patients of the optimal oxygenation group as the control. Finally, the mediation effect analysis results presented that the direct effect of the TWA-SpO2 was 0.072 (95% CI: 0.030-0.110, P<0.001).
Conclusions
The optimal pulse oximetry targets for oxygenation in sepsis patients were likely 95%~98%, corresponding with the lowest risk of in-hospital mortality. It was also observed after the indirect effect of FiO2 was removed.
Trial registration: Our study was registered with the Chinese Clinical Trials Registry on January 11, 2021, where the registration number was ChiCTR2000040149. http://www.chictr.org.cn/edit.aspx?pid=64427&htm=4.
Impact of climate change on nomadic herders’ livelihoods: a case study of the Bakarwal tribe in the western Himalayas in India
Authors: Ahmed Sharief , Iqbal Zaffar , Antahal Prakash C. 
Published: December 2022

Abstract

This study quantifies the impact of climate change on the livelihoods of nomadic herders in the western Himalayas in India, who depend on natural resources for their livelihood, and are herding livestock. In this research paper, we collected primary data from 235 nomadic herders on their perceptions regarding the variables of climate change. We analysed the primary data using factor analysis and found that due to climate change, in the last few decades, nomads have experienced less and untimely rainfall and increased temperature, which ultimately results in the fallen growth of pasture, degraded quality and quantity of pasture, pasture plants being replaced by weedy plants, shrunken the harvesting time of pasture, drying of sources of water in later days at winter residence, seasons have changed, experiencing unstable weather, and reduced grazing areas are bringing the drought-like situation in the area. Further, this creates significant challenges in raising livestock with less pasture, water availability, increased environmental diseases risk bringing starvation and death of animals, falling the quality and quantity of milk, wool and meat, and lowered the market price of final goods. This has a serious impact on the economic activities of nomadic herders in the region. Climate change also forced the nomadic herders in the region to early migration, which allowed them to face difficulties such as ice over mountain passes, less grass along the paths for grazing, unexpected avalanches, thunderstorms or hailstorms and intense rains on the way to uplands. Finally, this study brings to the notice of policymakers, climatologists, local governments, and animal health departments that climate change is endangering the life of nomadic herders, and we should develop appropriate plans to minimize the loss.
The ethanolic extract of Salvia lachnostachys Benth is not maternotoxic, does not alter reproductive performance, but has teratogenic potential
Authors: Ortiza Hudman Cunha , Neves Silvia Cordeiro , Kassuya Cândida Aparecida Leite , Coelho Henrique Rodrigues Scherer , Martins Allana C. F. , Vilela Marcelo Luiz Brandão , Nascimento Valter Aragão , Karuppusamy Arunachalam , Stefanello Maria Élida Alves , Oliveira Rodrigo Juliano , Gomes Roberto Silva 
Published: December 2022

Abstract
Salvia lachnostachys Benth is native to Brazil and has anti-inflammatory, anti-arthritic, cytotoxic, antitumor, and antihyperalgesic activities. The present study aimed to evaluate the effects of S. lachnostachys (EESl) ethanolic extract on reproductive performance, embryofetal development, and DNA integrity of pregnant female mice. Pregnant females were randomly divided into three experimental groups (n = 10): The Control group was treated with a vehicle, and treatment groups were administered with EESl at 100 and 1000 mg/kg, respectively. Treatment occurred by gavage throughout the gestational period until day 18. Afterward, reproductive performance, embryofetal development, and DNA integrity parameters were evaluated. The results indicated that EESl did not alter any reproductive performance parameters. However, it changed embryofetal outcome through reduced placental weight (EESl 100 mg/kg), decreased fetal weight (EESl 100 and 1000 mg/kg), and increased frequency of small for gestational age fetuses (EESl 1000 mg/kg). In addition, EES1 increased the frequency of external, visceral, and skeletal malformations. Because of the above, it is considered that EESl is not maternotoxic, does not alter reproductive performance, but does alter embryofetal development. Its use in the gestational period is not indicated due to its teratogenic potential.
Identification of low-acuity attendances in routine clinical information documented in German Emergency Departments
Authors: Slagman Anna , Fischer-Rosinský Antje , Legg David , Möckel Martin , Schmieder Kristin 
Published: December 2022

Abstract

Introduction It has not yet been possible to ascertain the exact proportion, characterization or impact of low-acuity emergency department (ED) attendances on the German Health Care System since valid and robust definitions to be applied in German ED routine data are missing. Methods Internationally used methods and parameters to identify low-acuity ED attendances were identified, analyzed and then applied to routine ED data from two EDs of the tertiary care hospitals Charité - Universitätsmedizin Berlin, Campus Mitte (CCM) and Campus Virchow (CVK). Results Based on the three routinely available parameters `disposition´, `transport to the ED´ and `triage´ 16.3% (n = 15 047) out of 92 477 presentations to the two EDs of Charité - Universitätsmedizin Berlin (CVK, CCM) in 2016 could be classified as low-acuity presentations. Conclusion This study provides a reliable and replicable means of retrospective identification and quantification of low-acuity attendances in German ED routine data. This enables both intra-national and international comparisons of figures across future studies and health care monitoring.
Primary cardiac myxofibrosarcoma of the left atrial and pericardium: a case report
Authors: Azuma Ryota , Sato Kazuyoshi , Sunadoi Hiroki , Ishii Yasushi , Tomaru Utano , Motohashi Masatoshi 
Published: December 2022

Abstract
Background: Primary cardiac myxofibrosarcoma is quite rare and commonly arises in the left atrial. Myxofibrosarcoma is an aggressive and has high mortality because of high rate of recurrence. It is considered that complete surgical resection is important but effective treatment options are not established.
Case presentation: We report a case of 75-year-old woman who developed myxofibrosarcoma spreading to left atrial and pericardium. To prevent sudden death by obstruction of mitral valve, we performed surgical resection of the tumor. The patient developed brain metastasis at two months after surgery, and eventually passed away due to brain hemorrhage at three postoperative months.
Conclusion: In this report, we described a very rare case of primary cardiac myxofibrosarcoma located not only in the left atrial but also in the pericardium. To prevent the recurrence of myxofibrosarcoma, combination of surgery, radiotherapy and chemotherapy should be needed.
Ecodatacube.eu: Analysis-ready open environmental data cube for Europe
Authors: Witjes Martijn , Parente Leandro Leal , Krizan Josip , Antonic Luka , Hengl Tomislav 
Published: December 2022

Abstract
The paper describes production steps and accuracy assessment of an analysis-ready (complete, consistent,
correct and current) open environmental data cube (2000–2021+) for continental Europe; at working
resolutions from 10 m to 30 m and with quarterly to annual estimates. The data cube is based on processing
and harmonizing earth observation (EO) images: Landsat GLAD ARD (2000–2020+), Sentinel-2 images
(2017–2021+) and Digital Elevation data. These datasets were created with accessibility, user-friendliness,
interoperability and synthesis in mind. This has required systematic spatiotemporal harmonization, efficient
compression, and imputation of missing values. To ensure a missing value percentage below 1%, the EO
data was first aggregated into four quarterly periods approximating the four seasons common in Europe
(winter, spring, summer and autumn), and then split into three percentiles (25th, 50th and 75th). Remaining
missing data in the Landsat time-series was imputed with a temporal moving window median (TMWM)
approach. The accuracy assessment shows TMWM gap-filling achieves higher performance in Southern
Europe, and lower performance in mountainous regions such as the Scandinavian Mountains, the Alps, and
the Pyrenees. The intended uses of the EcoDataCube platform include vegetation, soil, land cover and land
use mapping projects, environmental monitoring and automated generation of data for statistical offices
including Eurostat. Results further show that combining all four datasets produced in this work (DTM,
Landsat 30 m, Sentinel-2 30 m and Sentinel-2 10 m) yields the highest land cover classification accuracy,
with different datasets improving the results for different land cover classes. The Environmental data cube
for Europe is available under CC-BY license as Cloud-Optimized GeoTIFFs (ca. 12 TB in size) through
STAC and the EcoDataCube data portal.
Utilization of Carbonated Calcium Phosphate Cement for Contouring Cranioplasty in Patients with Syndromic Craniosynostosis
Authors: Wagner Connor S , Pontell Matthew E , Shakir Sameer , Xu Emily , Zhang Emily , Swanson Jordan W , Bartlett Scott P , Taylor Jesse A 
Published: December 2022

Abstract
Purpose
Carbonated calcium phosphate (CCP) cement is an alloplastic material which has been increasingly utilized for cranioplasty reconstruction, however there is a paucity of data investigating its use in patients with syndromic craniosynostosis. The purpose of this study was to characterize our institutional experience with CCP cement for secondary contouring cranioplasty in these patients to establish safety and aesthetic efficacy.
Methods
Patients with syndromic craniosynostosis undergoing cranioplasty with CCP cement from 2009-2022 were retrospectively reviewed for prior medical and surgical history, cranioplasty size, cement usage, and postoperative complications. Aesthetic ratings of the forehead region were quantified using the Whitaker scoring system at three time-points: preoperative (T1), < 6 months postoperative (T2), and > 1 year postoperative (T3).
Results
Twenty-one patients were included. Age at surgery was 16.2 ± 2.8 years, forehead cranioplasty area was 135 ± 112 cm2, and mass of cement was 17.2 ± 7.8 grams. Patients were followed for 3.0 ± 3.1 years. Whitaker scores decreased from 1.9 ± 0.4 at T1 to 1.4 ± 0.5 at T2 (p = 0.005). Whitaker scores at T2 and T3 were not significantly different (p = 0.720). Two infectious complications (9.5%) were noted, one at 4.5 months postoperatively and the other at 23 months, both requiring operative removal of CCP cement.
Conclusion
Our results suggest that aesthetic forehead ratings improve after CCP contouring cranioplasty and that the improvement is sustained in medium-term follow-up. Complications were uncommon, suggesting that CCP is relatively safe though longer-term follow-up is needed before reaching definitive conclusions.
Zinc Oxide Calcium Silicate Composite Attenuates Acute Tramadol Toxicity in Mice
Authors: ElShebiney Shaimaa A. , Elgohary Rania , Kenawy Sayed H. , El-Bassyouni Gehan T. , Hemzawy Esmat M.A. 
Published: December 2022

AbstractBackground Seizures are considered to be the most common symptom encountered in emergency- rushed tramadol-poisoned patients; accounting for 8% of the drug-induced seizure cases. Although, diazepam clears these seizures, the risk of central respiratory depression cannot be overlooked. Henceforth, three adsorbing composites were examined in a tramadol acute intoxication mouse model. Methods Calcium Silicate (Wollastonite) either non-doped or wet doped with iron oxide (3%Fe2O3) or zinc oxide (30% ZnO) were prepared. The composites’ adsorption capacity for tramadol was determined in vitro. Tramadol intoxication was induced in Swiss albino mice by a parenteral dose of 120 mg/kg. Proposed treatments were administered within 1 min at 5 increasing doses, i.p. The next 30 minutes, seizures were monitored as an intoxication symptom. Plasma tramadol concentration was recorded after two hours of administration. Results The 3% Fe2O3-containing composite (CSFe3), was found to be composed of mainly wollastonite with very little alpha–hematite. On the other hand, hardystonite and wellimite were developed in the 30%ZnO-containing composite (CSZn3). Micro-round and irregular nano-sized microstructures were established (The particle size of CS was 56nm, CSFe3 was 49 nm, and CSZn3 was 42 nm). The CSZn3 adsorption capacity reached 1497 mg of tramadol for each gram. Tramadol concentration was reduced in plasma and seizures were inhibited after its administration to mice at three doses. Conclusion The calcium silicate composite doped with ZnO presented a good resolution of tramadol-induced seizures accompanied by detoxification of blood, indicating its potential for application in such cases. Further studies are required.
Establishment of a prognostic signature for lung adenocarcinoma using cuproptosis-related lncRNAs
Authors: Yalimaimaiti Saiyidan , LIANG Xiaoqiao , ZHAO Haili , DOU Hong , LIU Wei , Yang Ying , NING Li 
Published: December 2022

Abstract
Objective To establish a prognostic signature for lung adenocarcinoma (LUAD) based on cuproptosis-related long non-coding RNAs (lncRNAs), and to study the immune-related functions of LUAD.
MethodsFirst, transcriptome data and clinical data related to LUAD were downloaded from the Cancer Genome Atlas (TCGA), and cuproptosis-related genes were analyzed to identify cuproptosis-related lncRNAs. Univariate COX analysis, least absolute shrinkage and selection operator (LASSO) analysis, and multivariate COX analysis were performed to analyze the cuproptosis-related lncRNAs, and a prognostic signature was established. Second, univariate COX analysis and multivariate COX analysis were performed for independent prognostic analyses. ROC curves, C index, survival curves, a nomogram, and principal component analysis (PCA) were performed to evaluate the results of the independent prognostic analyses. Finally, gene enrichment analyses and immune-related function analyses were also carried out.
Results (1) A total of 1,297 cuproptosis-related lncRNAs were screened. (2) A LUAD prognostic signature containing 13 cuproptosis-related lncRNAs was constructed (NIFK-AS1, AC026355.2, SEPSECS-AS1, AL360270.1, AC010999.2, ABCA9-AS1, AC032011.1, AL162632.3, LINC02518, LINC0059, AL031600.2, AP000346.1, AC012409.4). (3) The area under the multi-indicator ROC curves at 1, 3, and 5 years were AUC1 = 0.742, AUC2 = 0.708, and AUC3 = 0.762, respectively. The riskscore of the prognostic signature could be used as an independent prognostic factor that was independent of other clinical indicators. (4) The results of gene enrichment analyses showed that 13 biomarkers were primarily related to amoebiasis, the wnt signaling pathway, hematopoietic cell lineage. The ssGSEA volcano map showed significant differences between high- and low-risk groups in immune-related functions, such as human leukocyte antigen (HLA), Type_II_IFN_Reponse, MHC_class_I, and Parainflammation (P < 0.001).
Conclusions Thirteen cuproptosis-related lncRNAs may be clinical molecular markers for the prognosis of LUAD.
Country-of-Origin Bias towards COVID-19 Vaccination: Evidence from Turkey
Authors: Elgin Ceyhun , Kamilcelebi Hatime 
Published: December 2022

Abstract
Rapid vaccination against COVID-19 is viewed to be the only way to exit the current pandemic. In addition to the difficulties in the production and global distribution of the vaccines, one major barrier behind this is the vaccine hesitancy, particularly biases toward vaccines of different countries of origin among the public. We conducted a cross-sectional vignette study and designed five online surveys, where the participants were given some information about the efficacy of vaccines from different countries of origin. We then used standard mean comparison tests and (ordered) logistic regressions to provide evidence for the country-of-origin bias of the COVID-19 vaccines. 1615 participants answered our five surveys. Even though the two vaccines are reported to have the same efficacy, participants' subjective evaluation of the vaccine's efficacy and their willingness to get vaccinated is significantly higher when the vaccine is from Germany rather than from China.
Jute-integrated copper nanoparticle-embedded PSf membrane as highly efficient dye removal material
Authors: Prajapati Harsh , Busupalli Balanagulu 
Published: December 2022

Abstract
Membranes are actively used in a broad range of industries, including the water, energy, and biological sectors. Through pore functionalization of membranes of the ultrafiltration (UF), microfiltration (MF), and nanofiltration (NF) types with responsive behaviour, membranes that supply flux, metal sorption, dye sorption, and catalysis have been created. Through the manufacturing of polymers and surface modification, this technology offers a chance to enhance the performance of synthetic membranes. Discharge of hazardous containments, especially dyes and heavy metal ions, to freshwater streams has become a global concern due to many industries overlooking the environmental protocols in wastewater management. In the present study, polysulfone (PSf) membrane composites with high porosity and large internal pore volume were produced on a lab scale by adjusting the polymer coagulation conditions during phase inversion manufacturing and embedding copper nanoparticles for anti-fouling activity and pre-treated natural jute fibers, and the composites' adsorption capacities were measured. The composites were characterized thoroughly via FTIR, SEM, XRD, DLS. Finally, PSf-based membrane composites performances were investigated in terms of rejection (%) using methylene blue (MB) in water solution to assess their potential application in separation and purification processes.
A spatial-based approach presenting the “Within-plot Checks Design” applied to early selection stages in a forage breeding program
Authors: Ragalzi Celina Medeiros , de Oliveira Renato Gonçalves , Ribeiro Alessandra Gonçalves , Pereira Carlos Henrique , Jank Liana , Santos Mateus , Resende Rafael Tassinari 
Published: December 2022

Abstract
The aim of this study was to propose the “Within-plot Checks” design in the evaluation of hybrids from initial phases of the Guineagrass breeding program. The design uses common checks in each experimental plot to assess the quality of the microenvironmental in the experiment using plant-based indices associated with row and column arrangements. The design was tested at Embrapa Beef Cattle, Campo Grande, Brazil, where 2,100 hybrids were evaluated in the initial selection phase. Each plot consisted of 32 plants, with two checks and thirty hybrids. Evaluations were carried out on each plant individually and at different times of the year for the traits: Canopy Height; Regrowth Density; and Regrowth Speed. The plant-based index for each plot corresponds to the check mean for each trait. The mixed model methodology was used to test different random and fixed effects. The plant-based index used as a fixed effect was the factor with the greatest influence on the model fitness. Regardless of the trait considered, the association of the plant-based index with the row and column random effects was the one that showed the best performance between the models. Estimating the spatial variance helps to improve the accuracy of the variance components. The narrow and broad sense heritability coefficients were high (> 0.68) for all traits, indicating high prediction accuracy. The “Within-plot Checks” design, uses a plant-based index to characterize plot environmental quality potentially improving prediction accuracy and selection efficiency in the early stages of forage breeding programs.
An Improved Parameterization Procedure for NDDO-Descendant Semiempirical Methods
Authors: Ong Adrian Wee Wen , Cao Steve Yueran , Kwek Leong Chuan 
Published: December 2022

Abstract
MNDO-based semiempirical methods in quantum chemistry have found widespread application in the modelling of large and complex systems. A method for the analytic evaluation of first and second derivatives of molecular properties against semiempirical parameters in MNDO-based NDDO-descendant models is presented, and the resultant parameter Hessian is compared against the approximant currently used in parameterization for the PMx models. As a proof of concept, the exact parameter Hessian is employed in a limited reparameterization of MNDO for the elements C, H, N, O and F using 1206 molecules for reference data.
Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches
Authors: Amod Leah , Mohunlal Roxanne , Teixeira Nicole , Egan Timothy J. , Wicht Kathryn J. 
Published: December 2022

Abstract
The biomineral haemozoin, or its synthetic analogue β-haematin (βH), has been the focus of several target-based screens for activity against Plasmodium falciparum parasites. Together with the known βH crystal structure, the availability of this screening data makes the target amenable to both structure-based and ligand-based virtual screening. In this study, molecular docking and machine learning techniques, including Bayesian and support vector machine classifiers, were used in sequence to screen the in silico ChemDiv 300k Representative Compounds library for inhibitors of βH with retained activity against P. falciparum. We commercially obtained and tested a prioritised set of inhibitors and identified the coumarin and iminodipyridinopyrimidine chemotypes as potent in vitro inhibitors of βH and whole cell parasite growth.