bluuebunny/crossref_metadata_2025_split huggingface dataset:
The three pyridazines, three naphthyridines and two azoles: effect of the position of the second heteroatom on pK
aH of their eight conjugate acids
Authors: Rachuru Sanjeev , Padmavathi Devarakonda A. , Ramavath Ravi , Vandanapu Jagannadham , Skelton Adam A. 
Published: November 2022

Abstract
In the present work, how the position of the second nitrogen in the conjugate acids of the three pyridazines viz., 1,2-pyridazine, 1,3-pyridazine (the pyrimidine) and 1,4-pyridazine (the pyrazine) and three naphthyridines viz., cinnoline, quinazoline and quinoxaline changes the pK
aH systematically is taken up. They decrease nearly by a factor of half each time in the class of their own. In contrast there is an increase in the pK
aH when we move from pyrazole to imidazole. The pK
aH of pyrazole is less than imidazole by −4.45 units. Suitable explanations are given.
Expression of polycystic ovary syndrome candidate genes in bovine fetal and adult ovarian somatic cells
Authors: Liu Menghe , Hummitzsch Katja , Bastian Nicole A , Hartanti Monica D , Irving-Rodgers Helen F , Anderson Richard A , Rodgers Raymond J 
Published: November 2022

Polycystic ovary syndrome (PCOS) is an endocrine metabolic disorder that appears to have a genetic predisposition and a fetal origin. The fetal ovary has two major somatic cell types shown previously to be of different cellular origins and different morphologies and to differentially express 15 genes. In this study, we isolated the somatic gonadal ridge epithelial-like (GREL) cells (n  = 7) and ovarian fetal fibroblasts (n  = 6) by clonal expansion. Using qRT-PCR, we compared the gene expression levels of PCOS candidate genes with previous data on the expression levels in whole fetal ovaries across gestation. We also compared these levels with those in bovine adult ovarian cells including fibroblasts (n  = 4), granulosa cells (n  = 5) and surface epithelial cells (n  = 5). Adult cell types exhibited clear differences in the expression of most genes. In fetal ovarian cells, DENND1A and ERBB3 had significantly higher expression in GREL cells. HMGA2 and TGFB1I1 tended to have higher expression in fetal fibroblasts than GREL cells. The other 19 genes did not exhibit differences between GREL cells and fetal fibroblasts and FBN3, FSHB, LHCGR, FSHR and ZBTB16 were very lowly expressed in GREL cells and fibroblasts. The culture of fetal fibroblasts in EGF-containing medium resulted in lower expression of NEIL2 but higher expression of MAPRE1 compared to culture in the absence of EGF. Thus, the two fetal ovarian somatic cell types mostly lacked differential expression of PCOS candidate genes.

Lay summary
Polycystic ovary syndrome (PCOS) is one of the most common reproductive problems. The cause is not known so there are no specific treatments or prevention strategies. We know it can be linked to issues that occur in the womb and that some people may be more likely to get PCOS due to their genetic makeup. Our recent studies showed that many of the genes linked to PCOS were found to be switched on in the fetal ovary and are likely to be involved in the development of the fetal ovary. In order to improve our understanding of PCOS, we need to identify the type of cells in the fetal ovary where these genes are switched on. In this study, we examined the PCOS genes in two types of cells that mature as the fetal ovary develops and found very little difference between them but bigger differences to their mature adult counterparts.
Сучасні тенденції розвитку «екологічної» школи електоральних досліджень
Authors: Ставченко Сергій , Кривошеїн Віталій 
Published: November 2022

Роль просторових зв’язків у функціонуванні держави в сучасних умовах дедалі зростає. З огляду на це політичну сферу держави доцільно розглядати як територіально-політичну систему, яка є особливим поєднанням державної території, територіальної організації влади та регіонального розподілу політичної активності населення. У цьому контексті особливого значення набуває аналіз виборчої статистики в її територіальному розподілі. Саме цей напрям започаткував школу електоральних досліджень, яка виникла в Західній Європі як реакція на посилення ролі виборів у політичному житті і кількісного зростання виборчого корпусу. Теоретико-методологічною основою досліджень представників цієї школи є «екологічна» (контекстуальна, просторова) модель аналізу голосування, а, відповідно, саму школу прийнято називати «екологічною»
Мета: розкрити сучасні тенденції розвитку «екологічної» (контекстуальної, просторової) школи електоральних досліджень.
Результати дослідження: доведено, що інституалізація «екологічної» школи електоральних досліджень пов’язана з діяльністю Ф. Гогеля, який сформулював основне кредо «екологів» – будь-які дослідження у сфері електоральної поведінки мають базуватися на порівнянні результатів виборів і факторів. що може пояснити ці результати; простежено, що подальший розвиток «екологічної» школи у другій половині ХХ – на початку ХХІ століття здійснювали П. Буа, Р. Арон, М. Доган, Р. Хеберле, Дж. Сарторі, Г. Тінгстен та ін.
Висновки: «екологічна» (контекстуальна, просторова) школа електоральних досліджень зосереджена на розробці статистичних методів дослідження агрегованих кількісних даних для прогностичних цілей; політико-географічний підхід до аналізу результатів голосування дозволяє виявити просторові зміни поведінки виборців; перспективи «екологічного» підходу до вивчення електоральної поведінки пов’язані з поєднанням класичних методів «екологістів» з різними прийомами прикладного аналізу (у тому числі якісного).
Escola moderna e seus desajustes na contemporaneidade
Authors: Gema Mocellin Petrini Silvane , Wanderer Fernanda 
Published: November 2022

O presente artigo busca empreender uma discussão sobre questões relacionadas à escola instaurada na modernidade, cuja finalidade estava direcionada a produzir os corpos necessários para atuarem na configuração social que despontava na era industrial. Ao mesmo tempo lança luzes sobre um possível desalinhamento desta instituição basilar no que se refere à escola que se desenha na contemporaneidade, cujos desajustes evidenciam uma chamada “crise da escola”, passando a constituir-se como uma maquinavaria. Agora, outros são os corpos dos quais a escola deve se ocupar para produzir subjetividades vinculadas à produtividade e à rentabilidade que imperam na racionalidade neoliberal. Em virtude destes dois movimentos, procura tencionar o conceito maquinaria escolar criado por Varela e Álvarez-Uría (1992) articulando-o com os estudos de Sibilia (2012), Laval (2019) e Masschelein e Simons (2018) para pensarmos na emergência de uma maquinavaria escolar.
The structure of the narrative in the story of Baucis and Philemon
Authors: Czeti István 
Published: November 2022

AbstractThe Ovidian story of Baucis and Philemon can be divided into shorter sections based on the structure of the narrative, and several parallelisms and analogies can be perceived between these sections. In one section the number of vegetables and other edibles corresponds with the number of the edibles in the other, as well as with the arrangement of divine names in the text creating a palistrophe, thus showing the individual parts of the whole strory. The aim of this article is to present the Ovidian structure of the narrative of the story and make possible emendations of the widely accepted text utilising the most important medieval codices and this supposed structural framework.
Compressive properties of silicone Bouligand structures
Authors: Van Meerbeek I. M. , Lenhardt J. M. , Small W. , Bryson T. M. , Duoss E. B. , Weisgraber T. H. 
Published: November 2022

Abstract
This article presents an examination of silicone, Bouligand lattices in compression. Appearing frequently in biological organisms and manufacturing design, Bouligand structures comprise layers of parallel strands or fibers oriented in a helical fashion. They can exhibit exceptional fracture resistance when composed of rigid or composite materials. The behavior of elastomeric Bouligand structures, however, is less well understood. Additively manufactured (AM) elastomeric lattices have applications in stress mitigation, medical devices, and soft robotics. This article demonstrates that Bouligand structures are a useful addition to the design space of AM elastomers. By adjusting the layer-rotation parameters, lattice stress can increase by more than 300% without altering the porosity. Additionally, we introduce path length metrics that help explain the observed relationship between layer rotation and compression response.

Impact statement
Additive manufacturing (AM) continues to push the boundary of manufacturable structures and enhance the ability to robustly design for specific properties and behaviors. The more we understand the design space of a novel AM microstructure, the greater its application range. In this article, we describe the mechanical behavior of helicoidal, elastomeric lattices and introduce path length metrics to help explain their stress response. We show that these structures can exhibit a large range of mechanical behaviors in compression, making them well suited for applications such as stress mitigation and impact absorption. Additionally, the path length metrics could become useful design tools and may be applicable to a larger set of cellular structures. These findings expand our ability to rapidly design materials with highly specific and customizable properties to meet the needs of modern engineering challenges.

Graphical abstract
Book of Abstracts of the 21th European Conference on Eye Movements in Leicester 2022
Authors: McGowan Victoria , Pagán Ascensión , Paterson Kevin B. , Souto David , Groner Rudolf 
Published: November 2022

Contents
Keynotes:
Iain Gilchrist: Integrative Active Vision p 5
Ziad Hafed: A Vision for orienting in Primate Oculomotor Control Circuitry p 6
Fatema Ghasia: Miniscule Eye Movements Play a Major Role in Binocular Vision Disorders p.7
Miriam Spering: Eye Movements as a Window into Human Decision-Making p.8
Monica S. Castelhano: Explorations of how Scene Context and Previous Experience Dynamically Influence Attention and Eye Movement Guidance p.9

Symposia:
Eye Tracking and the Visual Arts p.19
Eye Movements during Text Processing and Multiline Reading p.23
Unstable Fixation and Nystagmus with a Focus on the Next Generation of Researchers p.84
Eye Movements as a measure of Higher-Level Text Processing p.97
Eye Movements in Memory Processes Between Working Memory and Long-Term Memory p.178
Symposium to Honour Alexander Pollatsek’s Legacy to Eye Movement Research p.204

Talks:
Reading p.30
Parafoveal Processing p.36
Cinical and Applied p.39
Visual Search p.92
Eye Movement Control in Reading I & II p.104 & 116 & 225
Reading Development p.110
Decision-Making p.122
Eye-tracking Methods p.128
Real World and Virtual Reality p.134
Chinese Reading p.185
Special Populations p.191
Visuo-motor p.195
Bilingual Reading p.201 & 217
Reading Comprehension p.219
Pupillometry p.235

Poster sessions:
Attention p.44 & 139
Cognition p. 49
Visuo-Motor p.62
Memory p.145
Methods p.150
Reading p. 57 & 155
Real World p.169
Social Cognition p.173
Efectos del cambio climático en la etnia de los quillacingas
Authors: Quijano Vodniza Armando José , García García Luz Elena 
Published: November 2022

El presente artículo de investigación tiene como objetivo realizar una lectura etnográfica de las estrategias comunitarias que los cabildos indígenas quillacingas del municipio de Pasto han implementado para adaptarse y mitigar los efectos nocivos generados por el cambio climático sobre el paisaje cultural (geografía sagrada). El texto se enfoca en los efectos de este fenómeno sobre el buen vivir y el etnodesarrollo.
La investigación adelantada corresponde al enfoque cualitativo de carácter hermenéutico, en donde se aplicó el método etnográfico, utilizándose las siguientes técnicas de recolección de la información: la entrevista, el taller y la observación participante. La unidad de trabajo estuvo conformada por doce integrantes de los cuatro cabildos quillacingas, para un total de cuarenta y ocho participantes entre miembros, líderes y personas mayores de 40 años que por su conocimiento del medio ambiente local se consideraron como informantes clave.
El estudio permitió establecer que el cambio climático está generando efectos adversos sobre el buen vivir en la etnia de los quillacingas, especialmente debido a las alteraciones en la concepción del tiempo y en el manejo del territorio respecto a los ciclos de producción agrícola, los ritos estacionales, las labores tradicionales y las prácticas comunitarias, así como el consecuente desplazamiento de algunos miembros de la familia hacia las ciudades en búsqueda de oportunidades de vida que son esquivas para ellos. Todo esto ha contribuido a aumentar la pobreza y la miseria, la desprotección, la inseguridad y la violencia, el desarraigo hacia sus territorios y la pérdida de identidad cultural.
Evaluación de la sustentabilidad cultural y ambiental de la minería tradicional en Quinchía, Risaralda. Caso de estudio corporación área de reserva especial minera (Corpoare)
Authors: Salazar Duque Yuliana 
Published: November 2022

La minería tradicional constituye una de las principales actividades económicas del municipio de Quinchía, localizado en el departamento de Risaralda. El municipio con una riqueza mineral en el 60 % de su territorio alberga 13 asociaciones mineras que, bajo la perspectiva neoliberal reflejada en aspectos como el neoextractivismo, han sido señaladas como insostenibles por sus efectos sobre los ecosistemas y los deficientes aportes a la economía nacional. Este es el contexto territorial que condujo a la investigación: “Evaluación de la sustentabilidad cultural y ambiental de la minería tradicional en Quinchía, Risaralda. Caso de estudio Corporación Área de Reserva Especial Minera (CORPOARE)”.
La investigación tuvo como objetivo analizar la minería tradicional del municipio de Quinchía hacia la evaluación de la sustentabilidad cultural y ambiental de la actividad. Para tal fin se definieron trece indicadores culturales y ambientales, nueve de ellos orientados a evaluar la sustentabilidad cultural y ambiental de la minería tradicional desarrollada por CORPOARE; una organización agrominera, conformada por 83 mineros tradicionales, localizada en un área de 584 hectáreas del municipio de Quinchía. Estos indicadores, orientados por el referente teórico sustentabilidad cultural y ambiental, permitieron concluir que la actividad minera desarrollada por CORPOARE en el contexto del desarrollo local es sustentable en los aspectos culturales, sociales y ambientales.
Perceived success factors in an outstanding school serving vulnerable students: Case-study of a Chilean public school
Authors: Celedon Gamboa Cristian , Vanderhoven Ellen , Proestakis Maturana Alejandro 
Published: November 2022

This research analyses, using a case-study approach, the perceived success factors in an outstanding Chilean public school serving socioeconomically vulnerable students. This qualitative study draws on qualitative interviews with school staff and class observations, using the Instructional Core model as an analytical framework. Analysis revealed that the beliefs and structural cultural values shared by the school community where more relevant to explaining school success than concrete practices, and highlighted the importance of the interrelation among success factors for understanding their impact on school effectiveness. Additionally, elements such as the ongoing and changing nature of success factors, the strong influence of leadership and internal relationships and the use of professional judgement and situated knowledge by teachers were also identified as key to understanding effectiveness. Lastly, the unintended consequences apparent in this case-study are discussed, as the school under study confronts the hostile and inequitable Chilean education policy context. Keywords: school effectiveness, vulnerable students, Chile, public school, thematic analysis.
El Impacto de los Cuentos Motores en el Desarrollo de las Habilidades Fundamentales en Niños con Capacidades Diversas en Educación Infantil
Authors: Gómez Domí­nguez Ma Teresa , Mora Ana Ma Moral , Ros Ros Concepción , Gómez Domínguez Valentina 
Published: November 2022

El objeto de este estudio es constatar los efectos de la implementación de cuentos motores en el desarrollo de las habilidades fundamentales: adaptativa, motora, cognitiva y personal-social en un aula inclusiva de Educación Infantil con niños con capacidades diversas. Para ello se ha procedido a la adaptación de un cuestionario ad hoc proveniente del Inventario de desarrollo Battelle.Â Los Ítems contenidos en el mismo se adecuan a acciones elegidas e introducidas en los cuentos motores y que, a su vez, permiten la observación de su consecución.
Â La muestra está conformada por 20 niños, con y sin diversidad funcional, a los cuales se les evaluaran mediante el cuestionario adaptado ad-hoc, seguido de la intervención, consistente en la implementación de 45 sesiones de cuentos motores, y finalizando con la nueva aplicación de este (pre y postest).
De los análisis realizados se desprende que el cuento motor resulta un recurso lúdico, flexible, motivador y fuente de aprendizaje significativo para los niños con y sin diversidad funcional; es una herramienta sencilla para valorar las capacidades de los niños y su adaptabilidad a la individualidad del alumnado lo convierte en un instrumento adecuado e inclusivo para su utilización en un aula de infantil.
Cuando la innovación docente despierta vocaciones. Efectos del aprendizaje colaborativo en estudiantes universitarios de Comunicación Organizacional
Authors: Martínez-Sanz Raquel 
Published: November 2022

La Universidad del siglo XXI apuesta por fomentar la empleabilidad de sus alumnos y para ello potencia el desarrollo de competencias profesionales y de habilidades sociales. A través de la innovación docente y de las metodologías activas es posible implicar al alumno y formarle en el buen hacer; responsabilidad indispensable en el ejercicio profesional de la Comunicación Organizacional, una especialidad caracterizada por tender puentes comunicativos y de confianza entre la organización y sus públicos. Este artículo presenta un doble objetivo, por un lado sistematizar las experiencias derivadas del Proyecto de Innovación Docente “Hazte donante” que, basándose en el aprendizaje colaborativo, involucra a los alumnos en la creación una campaña de concienciación transmedia para atraer a jóvenes donantes de sangre. Y por otro lado, se comprueba la evolución de los intereses de los participantes (n=80) respecto de la materia y su satisfacción con el proyecto y la metodología empleada. Para alcanzar tales objetivos se recurre a la observación participante, el diario de campo y la encuesta. El estudio demuestra las posibilidades del aprendizaje colaborativo por proyectos para afianzar contenidos, simular el ejercicio profesional y despertar vocaciones.
Multiple myeloma with extramedullary plasmacytoma: pathogenesis and clinical case
Authors: Firsova M. V. , Risinskaya N. V. , Solovev M. V. , Obukhova T. N. , Kislitsyna M. A. , Nikulina E. E. , Yakutik I. A. , Abramova T. V. , Sudarikov A. B. , Kovrigina A. M. , Mendeleeva L. P. 
Published: November 2022

Background. Multiple myeloma complicated by extramedullary plasmacytoma is an unfavorable variant of the disease. It remains unknown what triggers tumor transformation. The review presents literature data on the pathogenesis of extramedullary disease, as well as a clinical example of a comprehensive study of the tumor substrate.Aim. To study the molecular and biological characteristics of the tumor substrate of the bone marrow and extramedullary plasmacytoma using various research methods.Materials and methods. A 55-year-old patient was admitted to National Medical Research Center for Hematology with a diagnosis of multiple myeloma occurring with extramedullary plasmacytoma of the retroperitoneal space. dNA was isolated from samples of different localization (blood plasma, Cd138+ bone marrow cells, plasmacytoma and buccal epithelial cells). The profile of short tandem dNA repeats (STR) from the obtained samples was studied by multiplex polymerase chain reaction followed by fragment analysis. fluorescent in situ hybridization (fISH) of bone marrow Cd138+ cells was performed using various dNA probes. Comparative genomic hybridization on a microarray (arrayCGH) plasmacytoma dNA was also performed. The mutation profile of the KRAS, NRAS, BRAF genes was studied by Sanger sequencing in tumor samples of various localizations.Results. The induction therapy (vCd (bortezomib + cyclophosphamide + dexamethasone), vRd (bortezomib + lenalidomide + dexamethasone), daratumumab therapy) was ineffective, death occurred 4 months after the first clinical manifestations appeared. Comparison of STR markers of circulating cell-free tumor dNA (cfdNA), Cd138+ bone marrow cells, and plasmacytoma revealed the largest number of involved loci exactly in plasmacytoma’ dNA. A mutation in the NRAS gene was found only in plasmacytoma’ dNA. This indicates the presence of another clone of tumor cells in the extra-medullary plasmacytoma. Molecular karyotyping of plasmacytoma using the arrayCGH method revealed rearrangements of many chromosomes. 1p32.3 bi-allelic deletion, amplification of 1q21, 8q24/MyC rearrangements and del17p13 were confirmed by arrayCGH molecular karyotyping and fISH studies in bone marrow and plasmacytoma.Conclusion. A comprehensive molecular genetic study of the extramedullary plasmacytoma’ substrate is necessary to understand the pathogenesis mechanisms and, on this basis, to develop differentiated therapeutic approaches.
Variability in the Natural Frequencies of a Nine-Story Concrete Building from Seconds to Decades
Authors: Williams Ethan F. , Heaton Thomas H. , Zhan Zhongwen , Lambert Valere R. 
Published: November 2022

Abstract
Since 2001, the Southern California Seismic Network has archived continuous waveform data from strong-motion station CI.MIK in Caltech Hall (formerly Millikan Library)—a nine-story reinforced concrete building. Simple spectral analysis of this 20 yr record reveals that the building’s fundamental frequencies have increased gradually by 5.1% (east–west) and 2.3% (north–south), with larger long-term variability up to 9.7% (east–west) and 4.4% (north–south). This finding is unexpected, as previous analysis of forced vibration tests and strong-motion records has shown that between 1968 and 2003 the fundamental frequencies decreased by 22% (east–west) and 12% (north–south), largely attributed to minor structural damage and soil–structure system changes from major earthquakes. Today, the building’s apparent structural stiffness is comparable to what it was in 1986, before the Whittier Narrows earthquake. Using data from earthquakes and forced vibrations, we also document the building’s nonlinear dynamic elasticity, which is characterized by a rapid softening (decrease in apparent frequencies) at the onset of strong motion, followed by a slower, log–linear recovery trend over the scale of minutes. This nonlinear behavior does not appear to have changed with time.