bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: Prolonged Anorexia With Nausea Caused by Immune Checkpoint Inhibitors for Malignant Melanoma Treated Using Kampo Medicines Bukuryoingohangekobokuto and Ninjin’yoeito
Authors: Takayama Shin , Arita Ryutaro , Ishii Tadashi 
Published: April 2022

Immune checkpoint inhibitors (ICIs) are indicated for several cancers, including malignant melanoma. Anorexia and nausea resulting in malnutrition are side effects of ICIs. In such cases, conventional drugs are used for symptom relief, but the symptoms may persist. We report a case of advanced malignant melanoma with prolonged anorexia and nausea, which occurred after nivolumab administration, and was successfully treated using Kampo medicines. A 75-year-old man with nasal bleeding visited our hospital. A nasal scope revealed an obstructive tumor in the left nasal concha. Tissue biopsy showed malignant melanoma, and computed tomography showed metastasis to the liver and bone. Thus, the patient was diagnosed with stage IV malignant melanoma. He received radiotherapy (30 Gy) and nivolumab with ipilimumab four times, followed by nivolumab administration alone. During the administration of nivolumab, he complained of severe anorexia and nausea, with a numeric rating scale (no symptoms, 0; severe symptoms, 10) score of 10. He could not consume food because of these symptoms, even after nivolumab administration was discontinued. His blood pressure was 92/59 mmHg, his performance status (PS; no fatigue, 0; bedridden or disabled, 4) was 4, and his body weight gradually decreased from 60 to 39 kg in a month. The patient showed malnutrition and dehydration and experienced anxiety and depression. Nivolumab was terminated, and conventional symptomatic drugs were prescribed, but the symptoms persisted. We then prescribed 9.0 g/day of ninjin’yoeito (TJ-108, Tsumura and Co.) to allow recovery from anorexia and subsequently added bukuryoingohangekobokuto (TJ-116, Tsumura and Co.) to treat the persistent nausea. After treatment with these two Kampo medicines, the patient’s appetite gradually recovered. Along with the recovery of nutritional status, his PS improved to 0, his anxiety and depressive state improved, and his body weight increased to 60 kg. The patient remained in good condition without cancer recurrence. The patient’s clinical course shows the usefulness of Kampo medicine as supportive care for symptom relief and maintenance of nutritional and mental status during cancer treatment.
Restricted Intimal Ca2+ Signaling Associated With Cardiovascular Disease
Authors: Taylor Mark S. , Lowery Jordan , Choi Chung-Sik , Francis Michael 
Published: April 2022

Endothelial dysfunction is a key feature of cardiovascular disease (CVD) including atherosclerosis. Impaired endothelial signaling leads to plaque formation, vascular wall remodeling and widespread cardiovascular dysregulation. The specific changes along the vascular intima associated with atherosclerosis, including the vulnerable circulation downstream of the flow obstruction, remain poorly understood. Previous findings from animal models suggest that preservation of a distinct Ca2+ signaling profile along the arterial endothelial network is crucial for maintaining vasculature homeostasis and preventing arterial disease. Ca2+ signaling in the intact human artery intima has not been well characterized. Here, we employed confocal imaging and a custom analysis algorithm to assess the spatially and temporally dynamic Ca2+ signaling profiles of human peripheral arteries isolated from the amputated legs of patients with advanced CVD (peripheral artery disease and/or diabetes) or patients who had lost limbs due to non-cardiovascular trauma. In all tibial artery branches (0.5–5 mm diameter) assessed, the intima consistently elicited a broad range of basal Ca2+ signals ranging from isolated focal transients to broad waves. Arteries from patients with existing CVD displayed a restricted intimal Ca2+ signaling pattern characterized by diminished event amplitude and area. Stimulation of type-4 vanilloid transient receptor potential channels (TRPV4) amplified endothelial Ca2+ signals; however, these signals remained smaller and spatially confined in arteries from patients with CVD verses those without CVD. Our findings reveal a characteristic underlying basal Ca2+ signaling pattern within the intima of human peripheral arteries and suggest a distinct truncation of the inherent Ca2+ profile with CVD.
Drone-Based Position Detection in Sports—Validation and Applications
Authors: Russomanno Tiago Guedes , Blauberger Patrick , Kolbinger Otto , Lam Hilary , Schmid Marc , Lames Martin 
Published: April 2022

Radio and video-based electronic performance and tracking systems (EPTS) for position detection are widely used in a variety of sports. In this paper, the authors introduce an innovative approach to video-based tracking that uses a single camera attached to a drone to capture an area of interest from a bird’s eye view. This pilot validation study showcases several applications of this novel approach for the analysis of game and racket sports. To this end, the authors compared positional data retrieved from video footage recorded using a drone with positional data obtained from established radio-based systems in three different setups: a tennis match during training with the drone hovering at a height of 27 m, a small-sided soccer game with the drone at a height of 50 m, and an Ultimate Frisbee match with the drone at a height of 85 m. For each type of playing surface, clay (tennis) and grass (soccer and Ultimate), the drone-based system demonstrated acceptable static accuracy with root mean square errors of 0.02 m (clay) and 0.15 m (grass). The total distance measured using the drone-based system showed an absolute difference of 2.78% in Ultimate and 2.36% in soccer, when compared to an established GPS system and an absolute difference of 2.68% in tennis, when compared to a state-of-the-art LPS. The overall ICC value for consistency was 0.998. Further applications of a drone-based EPTS and the collected positional data in the context of performance analysis are discussed. Based on the findings of this pilot validation study, we conclude that drone-based position detection could serve as a promising alternative to existing EPTS but would benefit from further comparisons in dynamic settings and across different sports.
Association of Homocysteine Levels With Medial Temporal Lobe Atrophy Among Carriers and Non-carriers of APOE ε4 in MCI Subjects
Authors: Ma Jun , Ma Ling-Yun , Man FengYuan , Zhang Guili 
Published: April 2022

BackgroundDifferent clinical subtypes of mild cognitive impairment (MCI) involve heterogeneous underlying etiologies. This study investigated the association between demographics, neuropsychological performance, apolipoprotein E (APOE) genotype and magnetic resonance imaging (MRI) measures in patients with MCI (amnestic [aMCI] and non-amnestic [naMCI]).MethodsThis case–control study included 130 aMCI patients, 58 naMCI patients, and 1,106 healthy controls (HCs). APOE genotypes, medial temporal lobe atrophy (MTA), neurological evaluation results, and white matter hyperintensities (WMH) were investigated. Serum folate and vitamin B12 concentrations were analyzed by radioimmunoassay, and plasma hyperhomocysteinemia (Hcy) was assessed by a high-performance liquid chromatography-fluorescence method.ResultsSerum folate levels were significantly lower, but plasma Hcy levels were higher, in patients with aMCI and naMCI than in healthy controls. There were significantly higher MTA scores in the aMCI group than the healthy control group. Multiple linear regression showed that serum Hcy and folate concentrations were positively associated with MTA (p &lt; 0.05), while APOE4 showed a significant negative association with MTA in the aMCI group (p &lt; 0.01). In addition, moderate/severe WMH showed a significant negative association with MTA in the naMCI and HC groups (p &lt; 0.01).ConclusionThe combined presence of APOE4 and Hcy is associated with aMCI in elderly individuals, while moderate/severe WMH is related to naMCI, which suggests etiological differences across MCI subtypes.
Tuina for Enuresis in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Tong Chiin , He Qida , Ho Manin , Zhong Zhenghong , Wu Qibiao , Chen Min 
Published: April 2022

ObjectiveTo evaluate the effects of Tuina (massage) vs. non-Tuina traditional Chinese medicine (TCM) treatments on nocturnal enuresis in children.MethodsA systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted following the Preferred Reported Items for Systematic Review and Meta-analysis (PRISMA) guidelines. RevMan 5.3 software was used for meta-analysis.ResultsTwelve RCTs recruiting a total of 1,007 children were included. Meta-analysis results showed that, compared with non-Tuina TCM treatments, Tuina could significantly improve the total effective rate of children's enuresis [RR = 1.29, 95%CI (1.22–1.36), P &lt; 0.00001]. The results of subgroup analyses indicated that the total effective rate of Tuina combined with acupuncture in the treatment of nocturnal enuresis was higher than acupuncture alone [RR = 1.24, 95%CI (1.12–1.37), P &lt; 0.0001]. The total effective rate of Tuina in the treatment of enuresis in children was better than that of herbal medicine alone [RR = 1.45, 95%CI (1.31–1.61), P &lt; 0.00001]. The total effective rate of Tuina combined with herbal medicine in the treatment of enuresis in children was better than that of herbal medicine alone [RR = 1.16, 95%CI (1.06–1.26), P = 0.0007]. No adverse reactions of Tuina were reported in all included studies.ConclusionFrom the available evidence, Tuina, or Tuina combined with non-Tuina TCM treatments (acupuncture, or herbal medicine) can improve the clinical outcome of children with enuresis, indicating Tuina is a promising treatment choice for children's enuresis. However, because of the intrinsic limitations of the included studies, more high-quality randomized controlled trials with longer follow-up are still needed to further confirm the efficacy and safety of Tuina in the treatment of nocturnal enuresis in children.
Associations Between Income Status and Perceived Barriers to Using Long-Acting Reversible Contraception: An Exploratory Study
Authors: Henke Leah , Martins Summer , Boraas Christy 
Published: April 2022

IntroductionBarriers to long-acting reversible contraception (LARC) use in the United States have been described in prior studies, but few have focused on women's income status. We explored associations between income status and perceived LARC barriers in a community-based sample of reproductive-aged women.MethodsNon-pregnant, heterosexually active women aged 18 to 40 years completed a cross-sectional survey at a large community event in the Midwestern U.S. in 2018. Outcome measures were comprised of 26 survey items gauging perceived barriers to LARC use (e.g., access barriers, side effects). We estimated crude and age-adjusted prevalence ratios (PRs) for each outcome by participants' income status: low-income (≤ 200% of federal poverty guideline) versus higher income.ResultsLow-income women (n = 72) were significantly more likely than higher income women (n = 183) to endorse 11 of the 26 barriers to LARC use (PR range, 1.23–7.63). Cost of LARC was the most frequently identified access barrier and was more acute for low-income women (PR 1.57, 95% CI 1.17–2.11). After adjustment for age, most associations were attenuated. However, low-income women were still more likely to report concerns about LARC use due to family expectations or beliefs (aPR 3.69, 95% CI 1.15–11.8).ConclusionLow-income women perceive more barriers to LARC access and more negative perceptions about use. While these associations also correlate with age, they nonetheless reflect concerns that impact contraceptive equity. Efforts to increase LARC access should address these barriers and focus on concerns more common among low-income women regarding LARC use.
Investigating the Social Network Structure of Physical Literacy Scholars to Advance a Paradigm for Physical Activity Promotion
Authors: Lower-Hoppe Leeann M. , Kim Amy Chan Hyung , Brgoch Shea M. , Zwolski Christin M. , Schmitt Laura , Paponetti Matthew K. , Quatman-Yates Catherine C. 
Published: April 2022

PurposePhysical literacy has quickly gained global attention as a holistic approach to combat physical inactivity and obesity. However, research silos may limit the growth and application of the physical literacy paradigm for effective physical activity promotion. The purpose of this study was to measure the underlying network structure of scholars publishing on physical literacy (focusing on empirical research) through co-authorship analysis.MethodsData collection resulted in 1,070 documents related to physical literacy retrieved. A total of 198 articles met inclusion criteria and were included in the full network, with authors operationalized as actors in the network. A total of 75 empirical studies were included in the sub-network for critical appraisal and further analysis. Social network analysis was then conducted at the macro- and component-level, using quantification and visualization techniques.ResultsResults revealed a collaborative, yet fragmented physical literacy network with sub-groups representing substantive and geographically diverse scholars. The majority of scholarship lacked empirical evidence, suggesting a research-practice gap.ConclusionRecommendations for advancing physical literacy research and practice include strategic collaborations that transcend geographic and disciplinary boundaries, cooperative efforts across scholars and practitioners, and productive discourse through professional avenues to progress knowledge generation, dispersion, and application.
Trans-Nasion-Complex Approach for Endoscopic Modified Lothrop Procedure: Conception, Anatomy, and Technique
Authors: Zhao Yu , Liu Jianfeng , Yang Dazhang , Han Jun , Zhao Jianhui , Wang Yibei 
Published: April 2022

BackgroundThe endoscopic modified Lothrop procedure (EMLP) is an important procedure used to address frontal and anterior skull-base lesions. Two techniques were established, namely, the inside-out approach and the outside-in approach. The former technique take the frontal recess and the first olfactory filament (FOF) as key landmarks while the latter use the FOF as posterior boundary. In some cases, however, these two landmarks are not available. Therefore, we supplement the outside-in approach and named it trans-nasion-complex approach (TNCA) for EMLP that can be performed without locating these two landmarks.MethodsTwo dry human skulls were used to observe the bony nasion complex. Then, five colored silicon-injected human head specimens were dissected via TNCA for EMLP. Finally, the outcomes of patients who underwent TNCA were reviewed.ResultsThe nasion complex is an osseous complex that consists of the nasion and its adjacent structures, including the bilateral root of nasal bones, nasal process of frontal bones, anterior portion of the perpendicular plate of the ethmoid bone that connects with the inferior aspect of the nasal bones, and portions of the bilateral frontal process of the maxillary bones. Surgical landmarks for TNCA include the anterior superior portion of the nasal septum, anterior margin and axilla of the middle turbinate, frontal process of the maxilla bone, nasal process of the frontal bone and upper part of the nasal bone. These structures form a “mushroom sign” during cadaveric dissection and surgery. Twenty-one patients underwent TNCA, of whom 9 had tumors and 12 had chronic rhinosinusitis with nasal polyps (CRSwNP). None of them had major complications.ConclusionTNCA is expected to be a safe, and direct route for EMLP. Adequate understanding of the nasion complex and “mushroom sign” will be helpful to complete TNCA.
Зарубіжний досвід кримінально-правової протидії торгівлі людьми
Authors: Андрушко А. 
Published: April 2022

У статті на підставі вивчення законодавства 54 держав світу проаналізовано зарубіжний досвід кримінально-правової протидії торгівлі людьми. Зроблено висновок про те, що на сьогодні більшість національних законодавців наблизили своє розуміння сутності вказаного діяння із його визначенням, сформульованим у Палермському протоколі та в Конвенції Ради Європи про заходи щодо протидії торгівлі людьми.
Організаційно-правові засади використання поліцією України зарубіжного досвіду кримінологічної теорії розбитих вікон
Authors: Копан О. , Вознюк А. , Тичина Д. 
Published: April 2022

У статті розкрито багатогранність, складність системи заходів, спрямованих на захист прав і свобод людини й громадянина, честі та гідності особи, через призму положень теорії розбитих вікон як окремого напряму спеціально-кримінологічного запобігання злочинності.
Розкрито істотні ознаки теорії розбитих вікон, до яких віднесено мету, принципи, суб’єкти, об’єкт запобіжного впливу, а також заходи у формі здійснення владою міста, поліцією спільно із громадськістю, соціальними службами і агенціями підтримки (матеріальної, фізичної, психологічної) груп ризику (осіб, які мають судимість; наркоманів; вихідців із неблагополучних сімей тощо) та благоустрою міста, ліквідації пустирів, прибирання територій.
Доведена доступність і зрозумілість такої теорії, здатність принести корисні результати як для соціуму, так і кожного громадянина.
Акцентовано увагу на організаційних формах взаємодії поліції і громадськості. Розглянуто поняття, ґенезу та міжнародний досвід застосування кримінологічної теорії розбитих вікон, висвітлені питання форм взаємодії поліції з громадськістю у запобіганні кримінальним правопорушенням та вирішенні інших проблем громади тощо.
Реформування поліцейських сил Чеської Республіки: основні напрями правового забезпечення
Authors: Копча В. , Фрідманський Р. 
Published: April 2022

Стаття присвячена аналізу законодавчого забезпечення реформуванню поліцейських сил в Чеській Республіці. Особливу увагу приділено напрямам реформування поліції, які знайшли відображення в законодавстві. Дослідження реформи поліцейських сил у державах Центральної Європи і, зокрема, в Чеській Республіці є актуальним завданням, виходячи з низки аргументів. Перше, реформа поліції в Україні, яку було розпочато після Революції гідності 2014 р., потребує врахування досвіду реформаторських зусиль у тих державах, які успішно провели подібні реформи і Чеська Республіка належить до таких країн. Друге, серед багатьох аспектів реформи у цьому напрямі важливим є акцент на створення якісного законодавства, яке би створило основи для ефективної діяльності поліції, з одного боку, а, з іншого – забезпечило безумовне дотримання прав людини. Зроблено висновок, що вектор реформи поліції в цій державі відбувався у декілька етапів, протягом яких поліцейські сили набували нової якості поліцейської служби в державі, заснованій на верховенстві права. Об'єктивно відповідні ключові показники містилися у вимогах Європейського Союзу, підготовка до вступу до якого передбачала активне й цілеспрямоване реформування поліції на основі цих стандартів. Крім того, зміст і предмет законодавства Чеської Республіки щодо поліції може стати в нагоді для вітчизняного законодавця у таких аспектах як: а) організація поліцейської діяльності; б) окреслення спеціальних повноважень поліції; в) статусу поліцейських.
The Influence of Operative Intervention Volume on the State of the Vagina Microbiocenosis in Women with Uterine Leiomyoma
Authors: Маланчук Л.М. , Мартынюк В.Н. , Маланчин И.Н. , Кучма З.Н. , Маланчук С.Л. 
Published: April 2022

Работа посвящена оценке и сравнительному анализу микробиоценоза генитального тракта у женщин, которым выполнялась экстирпация матки с и без овариоэктомии. Установлено, что двусторонняя овариоэктомия приводит к формированию хирургической менопаузы и нарушений в микроэкосистеме влагалища в сторону элиминации лактофлоры и развития патогенной и условно-патогенной микрофлоры. На основании проведенного клинико-лабораторного обследования, которое дополнялось результатами бактериоскопического и бактериологического исследования влагалищных мазков, определены закономерности патогенетического течения бактериального вагиноза у женщин, перенесших оперативные вмешательства на яичниках.
This scientific work is devoted to the estimation and comparative analysis of microbiocenosis of vagina in women, which had extirpation uteruses with and without additions. It is set that bilateral ovarioectomy results in forming of surgical menopause and violations in the microecosystem of vagina towards the elimination of lactoflora and development of pathogenic and conditionally- pathogenic microflora. On the basis of the conducted clinical and laboratory inspection that was complemented by the results of bacterioscopical and bacteriological examination of vaginal strokes, conformities to law of nosotropic motion of bacterial vaginosis are certain for women that carried operative interventions on additions.
Placental Disorders: Early Diagnosis and Preventive Correction
Authors: Гутикова Л.В. , Смолей Н.А. , Усков С.И. 
Published: April 2022

Плацентарные нарушения осложняют до 60 беременностей и являются одной из причин перинатальной заболеваемости и смертности. Поиск этиопатогенетических механизмов развития плацентарных нарушений лежит в основе разработки разных способов лечения данного осложнения гестации. Важное значение в поддержании нормального маточно-плацентарного кровотока при физиологической беременности имеет базальная секреция оксида азота эндотелием сосудов в кровоток. В то же время метод исследования функции эндотелия как один из способов диагностики и прогнозирования развития плацентарных нарушений до настоящего времени не использовался. Отсутствие данных о взаимосвязи нарушения кровообращения в системе мать плацента плод и нарушения вазорегулирующей функции эндотелия и легли в основу совершенствования ранней диагностики и превентивной коррекции плацентарных нарушений. Разработанный нами метод визуализации просвета плечевой артерии с помощью ультразвука высокого разрешения позволяет исследовать вазорегулирующую функцию эндотелия. При выявлении показателей чувствительности плечевой артерии и напряжения сдвига на эндотелии выше нормального значения обследованные беременные формируют группу риска по развитию плацентарных нарушений. Разработанная схема коррекции, включающая метаболическую терапию и комплекс физических упражнений, позволяет нормализовать показатели вазорегуляции сосудистой стенки и снизить вероятность развития плацентарных нарушений на 70.
Placental disorders complicate up to 60 of pregnancies and are one of the causes of perinatal morbidity and mortality. The search for etiopathogenetic mechanisms for the development of placental disorders underlies the development of different methods of treating this complication of gestation. The basal secretion of nitric oxide by the vascular endothelium into the bloodstream is important in maintaining normal utero-placental blood flow during physiological pregnancy. At the same time, the method of studying endothelial function as one of the methods for diagnosing and predicting the development of placental disorders has not yet been used. The lack of data on the relationship between endothelial vasoregulatory dysfunction and circulatory dysfunction in the mother-placenta-fetus system formed the basis for improving early diagnosis and preventive correction of placental disorders. Our method of visualization of the brachial artery lumen using high-resolution ultrasound allows to study the vasoregulatory function of the endothelium. When the brachial artery sensitivity and endothelial shear stress are detected above the normal value, the examined pregnant women form a risk group for the development of placental disorders. The developed correction scheme, including metabolic therapy and a set of physical exercises, allows normalizing the parameters of vasoregulation of the vascular wall and reducing the likelihood of placental abnormalities by 70.