bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta‐analysis of genetic parameters for growth traits in meat, wool and dual‐purpose sheep breeds in the world using a random‐effects model
Authors: Abasi‐Mousa Sara , Varkoohi Sheida , Joezy Sahereh , Salary Nader , Khansefid Majid 
Published: December 2022

AbstractBackgroundThere is large variation in genetic parameters in literature for growth traits in sheep. Reliable estimation of genetic parameters is required for developing breeding programmes.ObjectivesThe aim of this study was to aggregate results of different studies by meta‐analysis to improve reliability of estimated parameters.MethodsIn the current study, 221 papers that have been published between 1995 and 2021 were reviewed. Using a random‐effects model in the Comprehensive Meta‐Analysis software, direct and maternal heritabilities, as well as, genetic and phenotypic correlations between growth traits were estimated in meat (M), wool (W) and dual‐purpose (D) sheep breeds. The growth traits in this study were birth weight, 3‐month weight, 6‐month weight, 9‐month weight and yearling weight.ResultsThe combined direct heritability was the lowest for birth weight (0.190 ± 0.004, 0.198 ± 0.003 and 0.196 ± 0.004 for M, W and D breeds, respectively) and the highest for yearling weight (0.264 ± 0.010, 0.304 ± 0.005 and 0.285 ± 0.020 for M, W and D breeds, respectively). The maternal heritability was the lowest for yearling weight (0.085 ± 0.003, 0.055 ± 0.002 and 0.052 ± 0.005 for M, W and D breeds, respectively) and the highest for 6‐month weight (0.240 ± 0.088, 0.164 ± 0.001 and 0.162 ± 0.006 for M, W and D breeds, respectively). The phenotypic and genetic correlations were lower between the weights measured at more distant intervals. The lowest genetic correlation was observed between birth weight and yearling weight (0.290 ± 0.051 for W breeds).ConclusionsThe small standard errors could indicate that the aggregation of results from different studies improved the reliability of estimated parameters and reduced range of 95% confidence intervals. Hence, the results could be used with greater level of confidence in sheep breeding programmes.
A multiconfigurational approach to the electronic structure of electro‐generated species of the Re2(μ‐Ph2PCH2PPh2)(S2CNEt2)4 complex
Authors: Obies Mohammed 
Published: December 2022

AbstractThe nature of Re−Re bonding in Re2(μ‐Ph2PCH2PPh2)(S2CNEt2)4 complex, including its neutral (10) and two oxidized (1+ and 12+) species, was explored utilizing state‐of‐the‐art quantum chemical methodologies within density functional theory (DFT) and complete active space self‐consistent field (CASSCF). Our results show that the ground state electron configuration of the 10 is
with an effective bond order (EBO) of 2.73 computed with CASSCF. The oxidation discloses an electron removal from a metal‐based orbital, giving 1+ and 12+ with an EBO of 2.71 and 2.64, respectively. The relative similarity in EBO values among neutral and oxidized species suggests that the oxidation processes have almost no effect on the Re−Re bond strength even though electrons removal from metal‐based orbitals because the electrons that occupied the
components of Re−Re bonds in 1+ and 12+ localized on the two Re ions, thus, they were excluded from EBO estimation.
Automatische Annotation
Authors: Schumacher Mareike K. 
Published: December 2022

ZusammenfassungDie zentrale Methode, die in dieser Studie zur Anwendung kommt, ist die Named Entity Recognition (NER), deren methodische Grundlagen in diesem Kapitel beschrieben werden. Wird die in der Computerlinguistik entwickelte Methode in der Literaturwissenschaft nachgenutzt, so ist es notwendig, eine Domänenadaption durchzuführen und dabei den State of the Art in der Ursprungsdomäne im Blick zu behalten. Nachdem die Grundlagen von NER und Domänenadaption beschrieben wurden, steht im letzten Unterkapitel dieses Abschnitts eine ausführliche Methodenkritik.
Der Raumindexwert (RIW) und weitere Indexwerte
Authors: Schumacher Mareike K. 
Published: December 2022

ZusammenfassungUm die Darstellung von Raum in Erzähltexten messbar zu machen, kann eine Formel zur Errechnung eines Indexwertes genutzt werden, die in diesem Kapitel vorgestellt wird. In die Berechnung wird die Explizitheit der jeweiligen Kategorie von Indikatoren narrativen Raumes ebenso einbezogen wie die Textlänge. Neben dem Umfassenden Raumindexwert (RIW) können noch weitere Indexwerte berechnet werden, die hier ebenfalls eingeführt werden.
Sharp and quantitative estimates for the p-Torsion of convex sets
Authors: Amato V. , Masiello A. L. , Paoli G. , Sannipoli R. 
Published: December 2022

AbstractLet$$\Omega \subset \mathbb {R}^n$$Ω⊂Rn,$$n\ge 2$$n≥2, be a non-empty, bounded, open and convex set and letfbe a positive and non-increasing function depending only on the distance from the boundary of$$\Omega $$Ω. We consider thep-torsional rigidity associated to$$\Omega $$Ωfor the Poisson problem with Dirichlet boundary conditions, denoted by$$T_{f,p}(\Omega )$$Tf,p(Ω). Firstly, we prove a Pólya type lower bound for$$T_{f,p}(\Omega )$$Tf,p(Ω)in any dimension; then, we consider the planar case and we provide two quantitative estimates in the case$$f\equiv 1 $$f≡1.
Inpatient GHB withdrawal management in an inner-city hospital in Sydney, Australia: a retrospective medical record review
Authors: Siefried Krista J. , Freeman Georgia , Roberts Darren M. , Lindsey Rhiannon , Rodgers Craig , Ezard Nadine , Brett Jonathan 
Published: December 2022

AbstractRationaleRegular consumption of gamma-hydroxybutyrate (GHB) may result in a dependence syndrome that can lead to withdrawal symptoms. There are limited data on medications to manage GHB withdrawal.ObjectivesTo examine characteristics associated with delirium and discharge against medical advice (DAMA), in the context of implementing a GHB withdrawal management protocol at an inner-city hospital in 2020.MethodsWe retrospectively reviewed records (01 January 2017–31 March 2021), and included admissions that were ≥ 18 years of age, admitted for GHB withdrawal, and with documented recent GHB use. Admissions were assessed for demographics, medications administered, features of delirium, ICU admission, and DAMA. Exploratory analyses were conducted to examine factors associated (p < 0.2) with features of delirium and DAMA.ResultsWe identified 135 admissions amongst 91 patients. Medications administered included diazepam (133 admissions, 98.5%), antipsychotics (olanzapine [70 admissions, 51.9%]), baclofen (114 admissions, 84%), and phenobarbital (8 admissions, 5.9%). Features of delirium were diagnosed in 21 (16%) admissions. Delirium was associated with higher daily GHB consumption prior to admission, while duration of GHB use, time from presentation to first dose of diazepam, and concomitant methamphetamine use were inversely associated with delirium. DAMA occurred amongst 41 (30%) admissions, and was associated with a longer time from presentation to first dose of baclofen, while being female and receiving a loading dose of diazepam were inversely associated.ConclusionsThis study adds to the literature in support of the safety and feasibility of diazepam and baclofen for the management of GHB withdrawal. Prospective, randomised trials are required.
Stabilization and quantitative measurement of nicotinamide adenine dinucleotide in human whole blood using dried blood spot sampling
Authors: Matsuyama Ryo , Omata Tomoyo , Kageyama Michiharu , Nakajima Ryota , Kanou Masanobu , Yamana Kei 
Published: December 2022

AbstractNicotinamide adenine dinucleotide (NAD+) is a coenzyme essential for energy production. Recently, associations between NAD+ and aging-related diseases have been reported, and NAD+ precursors that increase NAD+ concentration in the body have been acknowledged as anti-aging supplements. However, there have been only a few studies on the link between aging or aging-related diseases and human blood NAD+ concentration because NAD+ and its precursors are unstable in blood and difficult to measure. Therefore, we aimed to construct a quantitative NAD+ measurement method that is simpler than the existing methods. The calibration standards of NAD+ showed good linearity (0.9936 to 0.9990) in the range of 0.25 to 200 μM, and the lower limit of quantification was 0.5 to 2 μM. We found that QIAcard FTA DMPK-B maintained NAD+ stability of 85% or more for at least 2 weeks at 4 °C and 1 week at room temperature using the dried blood spot method. Additionally, NAD+ stability in the blood extraction solution was more than 90% for 2 months. To our knowledge, there has been no report on a quantitative NAD+ measurement method in human whole blood that can be performed with as little as 5 μL of blood and can be easily implemented at both medical clinics and private homes. Our simple and convenient method has the potential to become the gold standard for NAD+ measurement in blood. It is expected to contribute to the acceleration of research on the correlation between aging or aging-related diseases and NAD+ concentration in human blood.
Prevalence of gestational diabetes mellitus in women with a family history of type 2 diabetes in first- and second-degree relatives
Authors: Monod Cécile , Kotzaeridi Grammata , Linder Tina , Eppel Daniel , Rosicky Ingo , Filippi Valeria , Tura Andrea , Hösli Irene , Göbl Christian S. 
Published: December 2022

Abstract
Aims
A family history of type 2 diabetes mellitus (T2DM) markedly increases an individual's lifetime risk of developing the disease. For gestational diabetes (GDM), this risk factor is less well characterized. This study aimed to investigate the relationship between family history of T2DM in first- and second-degree relatives in women with GDM and the differences in metabolic characteristics at early gestation.

Methods
This prospective cohort study included 1129 pregnant women. A broad risk evaluation was performed before 16 + 0 weeks of gestation, including a detailed family history of the different types of diabetes and a laboratory examination of glucometabolic parameters. Participants were followed up until delivery and GDM assessed according to the latest diagnosis criteria.

Results
We showed that pregnant women with first- (FHD1, 26.6%, OR 1.91, 95%CI 1.16 to 3.16, p = 0.005), second- (FHD2, 26.3%, OR 1.88, 95%CI 1.16 to 3.05, p = 0.005) or both first- and second-degree relatives with T2DM (FHD1 + D2, 33.3%, OR 2.64, 95%CI 1.41 to 4.94, p < 0.001) had a markedly increased risk of GDM compared to those with negative family history (FHN) (n = 100, 15.9%). The association was strongest if both parents were affected (OR 4.69, 95%CI 1.33 to 16.55, p = 0.009). Women with FHD1 and FHD1 + D2 had adverse glucometabolic profiles already in early pregnancy.

Conclusions
Family history of T2DM is an important risk factor for GDM, also by applying the current diagnostic criteria. Furthermore, we showed that the degree of kinship plays an essential role in quantifying the risk already at early pregnancy.
The positive impact of cisternostomy with cisternal drainage on delayed hydrocephalus after aneurysmal subarachnoid hemorrhage
Authors: Garvayo Marta , Messerer Mahmoud , Starnoni Daniele , Puccinelli Francesco , Vandenbulcke Alberto , Daniel Roy T. , Cossu Giulia 
Published: December 2022

Abstract
Background
Hydrocephalus is one of the major complications of aneurysmal subarachnoid haemorrhage (aSAH). In the acute setting, an external ventricular drain (EVD) is used for early management. A cisternal drain (CD) coupled with the micro-surgical opening of basal cisterns can be an alternative when the aneurysm is clipped. Chronic hydrocephalus after aSAH is managed with ventriculo-peritoneal (VP) shunt, a procedure associated with a wide range of complications. The aim of this study is to analyse the impact of micro-surgical opening of basal cisterns coupled with CD on the incidence of VP shunt, compared to patients treated with EVD.

Methods
The authors conducted a retrospective review of 89 consecutive cases of patients with aSAH treated surgically and endovascularly with either EVD or CD between January 2009 and September 2021. Patients were stratified into two groups: Group 1 included patients with EVD, Group 2 included patients with CD. Subgroup analysis with only patients treated surgically was also performed. We compared their baseline characteristics, clinical outcomes and shunting rates.

Results
There were no statistically significant differences between the two groups in terms of epidemiological characteristics, WFNS score, Fisher scale, presence of intraventricular hemorrhage (IVH), acute hydrocephalus, postoperative meningitis or of clinical outcomes at last follow-up. Cisternostomy with CD (Group 2) was associated with a statistically significant reduction in VP-shunt compared with the use of an EVD (Group 1) (9.09% vs 53.78%; p < 0.001). This finding was confirmed in our subgroup analysis, as among patients with a surgical clipping, the rate of VP shunt was 43.7% for the EVD group and 9.5% for the CD group (p = 0.02).

Conclusions
Cisternostomy with CD may reduce the rate of shunt-dependent hydrocephalus. Cisternostomy allows the removal of subarachnoid blood, thereby reducing arachnoid inflammation and fibrosis. CD may enhance this effect, thus resulting in lower rates of chronic hydrocephalus.
Effect of legal regulation of supplemental feeding on space use of red deer in an area with chronic wasting disease
Authors: Mysterud Atle , Rivrud Inger Maren , Brekkum Øystein , Meisingset Erling L. 
Published: December 2022

AbstractSupplemental feeding of cervids during winter is a widespread management practice, but feeding may increase the risk of disease transmission. Therefore, legal regulations to limit supplemental feeding are often implemented when dealing with severe infectious diseases, such as chronic wasting disease (CWD) in cervids. However, it is currently unclear whether these regulations result in decreased spatial clustering and aggregation as intended. Supplemental feeding is expected to restrict the movement of cervids. Therefore, a ban on feeding may also result in wider space use and a risk of geographic spread of disease. The space use of 63 GPS-marked red deer (Cervus elaphus) was investigated before (n = 34) and after (n = 29) the implementation of a legal regulation aimed at limiting the supplemental feeding of cervids during winter in a CWD-affected region of Nordfjella, Norway. Snow depth was the main determinant of the space use for red deer. A moderate reduction in the number of GPS positions in spatial clusters was evident during periods of deep snow once the ban was in place. Sizes of core areas (Kernel 50%), home ranges (Kernel 95%), and dispersion (MCP 100%, number of 1 km2 pixels visited per deer) declined from January to March and with increasing snow depth. Dispersion (number of 1 km2 pixels visited per deer) did not depend on snow depth after the ban, and red deer used larger areas when snow depth was high after the ban compared to before. The ban on supplementary feeding had no effect on size of core areas or home ranges. Several potential factors can explain the overall weak effect of the ban on space use, including the use of agricultural fields by red deer, other anthropogenic feeding, and landscape topography. This study highlights that snow depth is the main factor determining space use during winter, and it remains to be determined whether the moderate reduction in spatial clustering during deep snow after the ban was sufficient to lower the risk of disease transmission.
Psoriatic arthritis: review of potential biomarkers predicting response to TNF inhibitors
Authors: Makos Anaïs , Kuiper J. H. , Kehoe O. , Amarasena R. 
Published: December 2022

AbstractPsoriatic arthritis (PsA) is a chronic and painful inflammatory immune-mediated disease. It affects up to 40% of people with psoriasis and it is associated with several comorbidities such as obesity, diabetes, metabolic syndrome, and hypertension. PsA is difficult to diagnose because of its diverse symptoms, namely axial and peripheral arthritis, enthesitis, dactylitis, skin changes, and nail dystrophy. Different drugs exist to treat the inflammation and pain. When patients do not respond to conventional drugs, they are treated with biologic drugs. Tumour necrosis factor inhibitors (TNFi’s) are commonly given as the first biologic drug; beside being expensive, they also lack efficacy in 50% of patients. A biomarker predicting individual patient’s response to TNFi would help treating them earlier with an appropriate biologic drug. This study aimed to review the literature to identify potential biomarkers that should be investigated for their predictive ability. Several such biomarkers were identified, namely transmembrane TNFα (tmTNF), human serum albumin (HSA) and its half-life receptor, the neonatal Fc receptor (FcRn) which is also involved in IgG lifespan; calprotectin, high mobility group protein B1 (HMGB1) and advanced glycation end products (AGEs) whose overexpression lead to excessive production of pro-inflammatory cytokines; lymphotoxin α (LTα) which induces inflammation by binding to TNF receptor (TNFR); and T helper 17 (Th17) cells which induce inflammation by IL-17A secretion.
Asylum Seekers’ Responses to Government COVID-19 Recommendations: A Cross-sectional Survey in a Swiss Canton
Authors: Morisod Kevin , Durand Marie-Anne , Selby Kevin , Le Pogam Marie-Annick , Grazioli Véronique S. , Sanchis Zozaya Javier , Bodenmann Patrick , von Plessen Christian 
Published: December 2022

AbstractAsylum seekers face multiple language, cultural and administrative barriers that could result in the inappropriate implementation of COVID-19 measures. This study aimed to explore their knowledge and attitudes to recommendations about COVID-19. We conducted a cross-sectional survey among asylum seekers living in the canton of Vaud, Switzerland. We used logistic regressions to analyze associations between knowledge about health recommendations, the experience of the pandemic and belief to rumors, and participant sociodemographic characteristics. In total, 242 people participated in the survey, with 63% of men (n = 150) and a median age of 30 years old (IQR 23–40). Low knowledge was associated with linguistic barriers (aOR 0.36, 95% CI 0.14–0.94, p = 0.028) and living in a community center (aOR 0.43, 95% CI 0.22–0.85, p = 0.014). Rejected asylum seekers were more likely to believe COVID-19 rumors (aOR 2.81, 95% CI 1.24–6.36, p = 0.013). This survey underlines the importance of tailoring health recommendations and interventions to reach asylum seekers, particularly those living in community centers or facing language barriers.
Complex moment-based methods for differential eigenvalue problems
Authors: Imakura Akira , Morikuni Keiichi , Takayasu Akitoshi 
Published: December 2022

AbstractThis paper considers computing partial eigenpairs of differential eigenvalue problems (DEPs) such that eigenvalues are in a certain region on the complex plane. Recently, based on a “solve-then-discretize” paradigm, an operator analogue of the FEAST method has been proposed for DEPs without discretization of the coefficient operators. Compared to conventional “discretize-then-solve” approaches that discretize the operators and solve the resulting matrix problem, the operator analogue of FEAST exhibits much higher accuracy; however, it involves solving a large number of ordinary differential equations (ODEs). In this paper, to reduce the computational costs, we propose operation analogues of Sakurai–Sugiura-type complex moment-based eigensolvers for DEPs using higher-order complex moments and analyze the error bound of the proposed methods. We show that the number of ODEs to be solved can be reduced by a factor of the degree of complex moments without degrading accuracy, which is verified by numerical results. Numerical results demonstrate that the proposed methods are over five times faster compared with the operator analogue of FEAST for several DEPs while maintaining almost the same high accuracy. This study is expected to promote the “solve-then-discretize” paradigm for solving DEPs and contribute to faster and more accurate solutions in real-world applications.
Comparative life cycle assessment for the manufacture of bio-detergents
Authors: Villota-Paz Javier Mauricio , Osorio-Tejada José Luis , Morales-Pinzón Tito 
Published: December 2022

Abstract
The increasing consumption of cleaning products deteriorates water resources due to harmful components such as phosphorus (P) and nitrogen (N) compounds, oils, bleach, and acids, typical compounds in traditional detergents. The use of biodegradable detergents as an environmentally friendly alternative has been proposed in different regions. In Colombia, resolution 1770/2018 sets a minimum biodegradability rate of 60% for the surfactants present in liquid detergents, which would reduce to a similar extent the impacts on water after their use. However, the environmental impacts of the supply chain of these detergents and their raw materials have not been evaluated so far. This study presents an environmental life cycle assessment of petroleum-based liquid detergents and a comparison to traditional solid detergents, based on the ISO 14040 standard and the ReCiPe-2016 impacts assessment method. A novel bio-detergent containing anionic plant-based surfactants was proposed in this analysis. The impacts of packaging and the distribution of the product to consumers were also considered. Raw materials contributed to 91% of the total of 314 g of CO2 eq generated per liter of liquid detergent, where the production of fatty alcohol sulfate and PET packaging shared 78.8% and 12.2% of the total impact, respectively. It was also determined that 5.4 L of water are consumed and 0.09 g of P eq and 0.1 g of N eq are emitted per liter of detergent. This liquid detergent presented better environmental performance than traditional detergents in all the impact categories, except for the fossil resource scarcity category. The evaluated detergent would significantly mitigate the generation of negative effects on ecosystems. Moreover, the substitution of PET for HDPE packaging could reduce the impacts on freshwater eutrophication by 10%, although the carbon footprint can slightly increase, which could be compensated due to its higher recyclability rate. In contrast, the proposed bio-detergent would not have significant benefits and would negatively affect water consumption and land use in its supply chain.
A Reply to Haze’s Argument Against Arbitrary Reference
Authors: Meléndez Gutiérrez Sofía 
Published: December 2022

AbstractThis paper is a response to Haze’s brief argument for the falsity of the theory that instantial terms refer arbitrarily, proposed by Breckenridge and Magidor in 2012. In this paper, I characterise instantial terms and outline the theory of arbitrary reference; then I reconstruct Haze’s argument and contend that it fails in its purpose. Haze’s argument is supposed to be a reductio ad absurdum: according to Haze, it proves that a contradiction follows from the most basic tenets of the theory of arbitrary reference. I will argue, however, that the contradiction in question follows not from these tenets, but from the surreptitious use that Haze makes of a self-referential expression. I conclude, consequently, that Haze’s argument is nothing more than an illustration of the well-known fact that self-referential expressions produce paradoxical results.