bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is “Gender Ideology” Western Colonialism?
Authors: Evang Jenny Andrine Madsen 
Published: October 2022

Abstract
How should we interrogate and oppose the current anti-gender misappropriation of postcolonial thought and struggles? Recently, we have seen a resurgence of organized anti-gender sentiments across Europe and the globe. A specific anti-gender rhetoric of victimization defines so-called Western genderists as a common enemy and colonizing force against “the people.” By focusing on some key European anti-gender actors, this article analyzes the strategic significance of the specific anti-gender assertion that gender is a neocolonial imposition. Beyond examining how the European anti-gender takeover of postcolonial framing is hypocritical—as anti-gender thinkers are themselves invested in the cisheterosexist myth that is perhaps the most colonial of all—the article argues that the misappropriation reveals something central about the racialized imaginary underpinning their rhetoric. They reproduce a racialized hierarchy of biological plasticity that positions white Europeans as both the ultimate saviors and the most vulnerable victims in the face of “genderism.” By unpacking the politics through which European anti-gender actors use the “non-Western” world as a rhetorical ruse to further Western supremacy, the article also shows the danger of the impulse to suspend postcolonial feminist critique in an effort to distance oneself from the anti-gender misappropriation of such theory and to unite around a common liberal front. Instead, it proposes that postcolonial thought is more vital than ever if we are to counter current anti-gender movements, their Islamophobia, and their transphobia.
GID as an Acceptable Minority; or, The Alliance between Moral Conservatives and “Gender Critical” Feminists in Japan
Authors: Yamada Hidenobu 
Published: October 2022

Abstract
This essay articulates how feminist, queer, and trans politics in the early aughts have become a precondition for the rise of feminist transphobia in Japan now. On the one hand, mainstream feminists in that period overlooked transphobia in the gender backlash from moral conservatives. On the other hand, a 2003 law on gender recognition for people with GID (gender identity disorder) endorsed the patriarchal system in which only some transsexual people would be recognized. The author argues that these backgrounds allow “gender critical” feminists to oppose what they see as the transgender ideology, forging an implicit alliance with moral conservatives while portraying themselves as being tolerant of people with GID.
Eligibility rates and representativeness of the General Medical Services scheme population in Ireland 2017-2021: A methodological report
Authors: Mattsson Molly , Flood Michelle , Wallace Emma , Boland Fiona , Moriarty Frank 
Published: October 2022

Background: In Ireland, the means tested General Medical Services (GMS) scheme provides access to a range of healthcare services at no or low cost to approximately one third of the population. Individuals eligible for the GMS scheme are often a focus of research, as a population that account for a large proportion of healthcare services use. The aim of this study is to describe the eligibility rates and representativeness of the GMS scheme population over time, with respect to age group, sex, and geographical area in Ireland. Methods: Population data was obtained from the Central Statistics Office (CSO), using 2016 Census figures and projected population figures for 2017-2021. GMS eligibility figures for 2016-2021 were obtained from the HSE Primary Care Reimbursement Service (PCRS). GMS eligibility rates and relative rates of eligibility were calculated for 2016-2021 by age group and sex. Additionally, 2016 eligibility rates were calculated by geographical area. Results: The crude eligibility rate decreased from 36.4% in 2016 to 31.2% in 2020, with a slight increase to 31.6% in 2021. In the 75+ years age group, 78.2% of the total population were eligible for the GMS scheme in 2021. The age group with the lowest rate of eligible individuals was the 25-34 age group, with 19.5% eligible in 2021. The eligibility rate was higher among females compared to males throughout the study period. The highest eligibility rate was seen in Donegal, with a crude rate of 52.8%. Dublin had the lowest rate, with a crude rate of 29.3%. Conclusions: GMS eligibility varies greatly depending on age, sex, and geographical area, and decreased between 2016 and 2021. This study uses the most up-to-date data available to provide age group, sex and area-based figures for GMS eligibility which may inform planning and conduct of research focusing on GMS-eligible individuals.
Ultrastructure and stability of cellular nanoparticles isolated from Phaeodactylum tricornutum and Dunaliella tertiolecta conditioned media
Authors: Božič Darja , Hočevar Matej , Jeran Marko , Kisovec Matic , Bedina Zavec Apolonija , Romolo Anna , Škufca David , Podobnik Marjetka , Kogej Ksenija , Iglič Aleš , Touzet Nicolas , Manno Mauro , Pocsfalvi Gabriella , Bongiovanni Antonella , Kralj Iglič Veronika 
Published: October 2022

Background: Cells in general secrete nanoparticles (NPs) which are believed to mediate intercellular communication. Recently, great efforts have been made to utilize them as delivery vectors. We aimed to harvest and identify NPs from liquid cultures of two marine microalgae Dunaliella tertiolecta and Phaeodactyum tricornutum. Methods: NPs were isolated from the culture conditioned media by differential ultracentrifugation by the protocol used for the isolation of extracellular vesicles. Microalgae and isolated NPs were examined by scanning electron microscopy (SEM) while isolated NPs were examined also by cryogenic transmission electron microscopy (cryo-TEM). The Triton X-100 detergent and temperature sensitivity of NPs was assessed by dynamic light scattering (DLS) through monitoring the intensity of the scattered light (I) and the distribution of hydrodynamic radii of NPs (Rh). Results: Two mechanisms of formation of NPs with average Rh 200 nm were observed in the D. tertiolecta culture: a disintegration of tubular protrusions, and cell decay. A part of the imaged D. tertiolecta NPs were membrane-enclosed vesicles, but the isolates also contained electron-dense NPs and nanofilaments. P. tricornutum NPs in the culture and in the isolate were homogeneous in size and shape. Their average Rh was 104 nm. The addition of surfactant to isolates resulted in a change in Rh distribution and a decrease of I in samples from both species, indicating decay of a part of NPs. Changes in the width of the I(Rh) peaks were observed at temperatures above 45 °C. Conclusions: A part of NPs found in isolates from microalgae D. tertiolecta and P. tricornutum were membrane-enclosed vesicles. However, the isolates obtained by a standard protocol for extracellular vesicle isolation by ultracentrifugation contained also a significant amount of other similar-sized nanoparticles. The isolates were partly susceptible to the addition of detergent and to temperature up to 80 degrees.
Optimization Under Rational Expectations: A Framework of Fully Coupled Forward-Backward Stochastic Linear Quadratic Systems
Authors: Hu Mingshang , Ji Shaolin , Xue Xiaole 
Published: October 2022

In this paper, we propose a general modeling framework for optimal control of stochastic fully coupled forward-backward linear quadratic (FBLQ) problems with indefinite control weight costs that stem from rational expectations models. We propose a new decoupling technique to obtain the optimal feedback control, which is accompanied by one kind of non-Riccati-type ordinary differential equation (ODE). By applying the completion-of-squares method, we prove the existence of the solutions for the obtained ODEs. The obtained results make it possible to compute the control and value function. For this FBLQ problem, the optimal control should depend on the entire trajectory of the state process. Several examples are given to illustrate our results. Funding: M. Hu’s research was supported by the National Science Foundation (NSF) [Grant 11671231] and the Young Scholars Program of Shandong University [Grant 2016WLJH10]. S. Ji’s research was supported by the NSF [Grant 11571203]. X. Xue’s research was supported by “The Fundamental Research Funds of Shandong University,” the NSF [Grants 12001316 and 61907022], and the Natural Science Foundation of Shandong Province [Grant ZR2019BF015].
Modifications to student quarantine policies in K–12 schools implementing multiple COVID-19 prevention strategies restores in-person education without increasing SARS-CoV-2 transmission risk, January-March 2021
Authors: Dawson Patrick , Worrell Mary Claire , Malone Sara , Fritz Stephanie A. , McLaughlin Heather P. , Montgomery Brock K. , Boyle Mary , Gomel Ashley , Hayes Samantha , Maricque Brett , Lai Albert M. , Neidich Julie A. , Tinker Sarah C. , Lee Justin S. , Tong Suxiang ,   COVID-19 Response Fieldwork Laboratory Teams, Orscheln Rachel C. , Charney Rachel , Rebmann Terri ,   Missouri School District Data Coordination Group, Mooney Jon , Rains Catherine , Yoon Nancy , Petit Machelle , Towns Katie , Goddard Clay , Schmidt Spring , Barrios Lisa C. , Neatherlin John C. , Salzer Johanna S. , Newland Jason G. 
Published: October 2022

Objective
To determine whether modified K–12 student quarantine policies that allow some students to continue in-person education during their quarantine period increase schoolwide SARS-CoV-2 transmission risk following the increase in cases in winter 2020–2021.

Methods
We conducted a prospective cohort study of COVID-19 cases and close contacts among students and staff (n = 65,621) in 103 Missouri public schools. Participants were offered free, saliva-based RT-PCR testing. The projected number of school-based transmission events among untested close contacts was extrapolated from the percentage of events detected among tested asymptomatic close contacts and summed with the number of detected events for a projected total. An adjusted Cox regression model compared hazard rates of school-based SARS-CoV-2 infections between schools with a modified versus standard quarantine policy.

Results
From January–March 2021, a projected 23 (1%) school-based transmission events occurred among 1,636 school close contacts. There was no difference in the adjusted hazard rates of school-based SARS-CoV-2 infections between schools with a modified versus standard quarantine policy (hazard ratio = 1.00; 95% confidence interval: 0.97–1.03).

Discussion
School-based SARS-CoV-2 transmission was rare in 103 K–12 schools implementing multiple COVID-19 prevention strategies. Modified student quarantine policies were not associated with increased school incidence of COVID-19. Modifications to student quarantine policies may be a useful strategy for K–12 schools to safely reduce disruptions to in-person education during times of increased COVID-19 community incidence.
Molecular and clinicopathological differences between depressed and protruded T2 colorectal cancer
Authors: Mochizuki Kenichi , Kudo Shin-ei , Kato Kazuki , Kudo Koki , Ogawa Yushi , Kouyama Yuta , Takashina Yuki , Ichimasa Katsuro , Tobo Taro , Toshima Takeo , Hisamatsu Yuichi , Yonemura Yusuke , Masuda Takaaki , Miyachi Hideyuki , Ishida Fumio , Nemoto Tetsuo , Mimori Koshi 
Published: October 2022

Background
Colorectal cancer (CRC) can be classified into four consensus molecular subtypes (CMS) according to genomic aberrations and gene expression profiles. CMS is expected to be useful in predicting prognosis and selecting chemotherapy regimens. However, there are still no reports on the relationship between the morphology and CMS.

Methods
This retrospective study included 55 subjects with T2 CRC undergoing surgical resection, of whom 30 had the depressed type and 25 the protruded type. In the classification of the CMS, we first defined cases with deficient mismatch repair as CMS1. And then, CMS2/3 and CMS4 were classified using an online classifier developed by Trinh et al. The staining intensity of CDX2, HTR2B, FRMD6, ZEB1, and KER and the percentage contents of CDX2, FRMD6, and KER are input into the classifier to obtain automatic output classifying the specimen as CMS2/3 or CMS4.

Results
According to the results yielded by the online classifier, of the 30 depressed-type cases, 15 (50%) were classified as CMS2/3 and 15 (50%) as CMS4. Of the 25 protruded-type cases, 3 (12%) were classified as CMS1 and 22 (88%) as CMS2/3. All of the T2 CRCs classified as CMS4 were depressed CRCs. More malignant pathological findings such as lymphatic invasion were associated with the depressed rather than protruded T2 CRC cases.

Conclusions
Depressed-type T2 CRC had a significant association with CMS4, showing more malignant pathological findings such as lymphatic invasion than the protruded-type, which could explain the reported association between CMS4 CRC and poor prognosis.
The electrical heart axis in fetuses with congenital heart disease, measured with non-invasive fetal electrocardiography
Authors: Noben L. , Lempersz C. , van den Heuvel E. R. , Zhan Z. , Vandenbussche F. P. H. A. , Coumans A. B. C. , Haak M. C. , Vullings R. , Oei S. G. , Clur S. A. B. , van Laar J. O. E. H. 
Published: October 2022

Objectives
To determine if the electrical heart axis in different types of congenital heart defects (CHD) differs from that of a healthy cohort at mid-gestation.

Methods
Non-invasive fetal electrocardiography (NI-fECG) was performed in singleton pregnancies with suspected CHD between 16 and 30 weeks of gestation. The mean electrical heart axis (MEHA) was determined from the fetal vectorcardiogram after correction for fetal orientation. Descriptive statistics were used to determine the MEHA with corresponding 95% confidence intervals (CI) in the frontal plane of all fetuses with CHD and the following subgroups: conotruncal anomalies (CTA), atrioventricular septal defects (AVSD) and hypoplastic right heart syndrome (HRHS). The MEHA of the CHD fetuses as well as the subgroups was compared to the healthy control group using a spherically projected multivariate linear regression analysis. Discriminant analysis was applied to calculate the sensitivity and specificity of the electrical heart axis for CHD detection.

Results
The MEHA was determined in 127 fetuses. The MEHA was 83.0° (95% CI: 6.7°; 159.3°) in the total CHD group, and not significantly different from the control group (122.7° (95% CI: 101.7°; 143.6°). The MEHA was 105.6° (95% CI: 46.8°; 164.4°) in the CTA group (n = 54), -27.4° (95% CI: -118.6°; 63.9°) in the AVSD group (n = 9) and 26.0° (95% CI: -34.1°; 86.1°) in the HRHS group (n = 5). The MEHA of the AVSD and the HRHS subgroups were significantly different from the control group (resp. p = 0.04 and p = 0.02).
The sensitivity and specificity of the MEHA for the diagnosis of CHD was 50.6% (95% CI 47.5% - 53.7%) and 60.1% (95% CI 57.1% - 63.1%) respectively.

Conclusion
The MEHA alone does not discriminate between healthy fetuses and fetuses with CHD. However, the left-oriented electrical heart axis in fetuses with AVSD and HRHS was significantly different from the control group suggesting altered cardiac conduction along with the structural defect.

Trial registration
Clinical trial registration number: NL48535.015.14.
Efficacy of abiraterone acetate for high-risk hormone-naïve metastatic prostate cancer: A comparison with combined androgen blockade therapy with bicalutamide and androgen deprivation therapy alone
Authors: Kanao Kent , Takahashi Takayuki , Umezawa Yuta , Okabe Takashi , Kaneko Go , Shirotake Suguru , Nishimoto Koshiro , Oyama Masafumi 
Published: October 2022

Background
The treatment landscape for men with metastatic hormone-naïve prostate cancer (mHNPC) has dramatically changed with the approval of next-generation anti-androgen drugs. We compared the treatment efficacy of abiraterone with that of combined androgen blockade (CAB) therapy and androgen deprivation therapy (ADT) alone in men with high-risk mHNPC.

Methods
In total, 146 Japanese men with high-risk mHNPC were retrospectively analyzed. As initial hormonal therapy, 30, 83, and 33 men were treated with ADT plus abiraterone (ABI group), ADT plus bicalutamide (CAB group), and ADT alone (ADT group), respectively. Treatment efficacy was compared using time to castration resistance (TTCR) and prostate-specific antigen (PSA) response among the groups. Propensity score matching analysis was also performed to adjust for baseline differences.

Results
The median (95% confidence interval [CI]) TTCR in the ABI, CAB, and ADT groups were not reached, 10.7 (7.6–13.8) months and 11.0 (7.9–12.4) months, respectively, and it was significantly longer in the ABI group than in the other groups (p = 0.0012, p = 0.0008). In propensity score matching analysis, the median TTCR was also significantly longer in the ABI group than in the other groups (hazard ratio [HR], 0.47; 95% CI, 0.22–0.98; p = 0.010; HR, 0.32; 95% CI, 0.12–0.85; p = 0.004). The number of men who achieved PSA levels ≤0.2 ng/mL after propensity score matching were significantly higher in the ABI group than in the other groups.

Conclusions
Our results provide important evidence regarding the superiority of abiraterone over CAB therapy and ADT alone for initial treatment for men with newly diagnosed mHNPC.
Do both timing and duration of screen use affect sleep patterns in adolescents?
Authors: Hartley Sarah , Royant-Parola Sylvie , Zayoud Ayla , Gremy Isabelle , Matulonga Bobette 
Published: October 2022

Background
Sleep duration has declined in adolescents over the last 30 years and screen use has been identified as a risk factor. Studies have examined the duration of screen use and screen-based activities but have not differentiated between evening and night-time use.

Methods
Cross sectional questionnaire survey of adolescents recruited in schools. Sleep habits on school nights and weekends, symptoms of insomnia and daytime repercussions were recorded using an online questionnaire administered in the classroom setting. Sleep deprivation (<7 hours in bed /night), school night sleep restriction (≥2 hours difference in sleep duration on school nights vs weekends), excessive sleepiness (score >6 on a visual analogue scale), duration of screen use and timing of screen use (evening vs after bedtime) were determined.

Results
2513 students (53.4% female, median age 15 years) were included. 20% were sleep deprived and 41% sleep restricted. A clear dose effect relationship in a model controlling for age, sex, school level and sociodemographic class was seen with all levels of night-time screen use on sleep deprivation and sleep restriction (>2 hours use sleep deprivation OR 5.23[3.03–9.00]. sleep restriction OR 2.05[1.23–3.42]) and > 2 hours evening use (>2 hours use sleep deprivation OR 2.72[2.15–3.44] sleep restriction OR 1.69[1.36–2.11]) but not moderate evening use. All night-time use and > 2 hours evening use increased the risk of insomnia, non refreshing sleep, and affected daytime function (daytime sleepiness, lack of energy and irritability).

Conclusions
Both duration of screen use and timing are associated with adverse effects on sleep and daytime functioning in adolescents. More than 2 hours evening use and all night-time use should be avoided.
Challenges and costs of donor screening for fecal microbiota transplantations
Authors: Bénard Mèlanie V. , de Bruijn Clara M. A. , Fenneman Aline C. , Wortelboer Koen , Zeevenhoven Judith , Rethans Bente , Herrema Hilde J. , van Gool Tom , Nieuwdorp Max , Benninga Marc A. , Ponsioen Cyriel Y. 
Published: October 2022

Background
The increasing interest to perform and investigate the efficacy of fecal microbiota transplantation (FMT) has generated an urge for feasible donor screening. We report our experience with stool donor recruitment, screening, follow-up, and associated costs in the context of clinical FMT trials.

Methods
Potential stool donors, aged between 18−65 years, underwent a stepwise screening process starting with an extensive questionnaire followed by feces and blood investigations. When eligible, donors were rescreened for MDROs and SARS-CoV-2 every 60-days, and full rescreening every 4−6 months. The costs to find and retain a stool donor were calculated.

Results
From January 2018 to August 2021, 393 potential donors underwent prescreening, of which 202 (51.4%) did not proceed primarily due to loss to follow-up, medication use, or logistic reasons (e.g. COVID-19 measures). 191 potential donors filled in the questionnaire, of which 43 (22.5%) were excluded. The remaining 148 candidates underwent parasitology screening: 91 (61.5%) were excluded, mostly due to Dientamoeba fragilis and/or high amounts of Blastocystis spp. After additional feces investigations 18/57 (31.6%) potential donors were excluded (mainly for presence of Helicobacter Pylori and ESBL-producing organisms). One donor failed serum testing. Overall, 38 out of 393 (10%) potential donors were enrolled. The median participation time of active stool donors was 13 months. To recruit 38 stool donors, €64.112 was spent.

Conclusion
Recruitment of stool donors for FMT is challenging. In our Dutch cohort, failed eligibility of potential donors was often caused by the presence of the protozoa Dientamoeba fragilis and Blastocystis spp.. The exclusion of potential donors that carry these protozoa, especially Blastocystis spp., is questionable and deserves reconsideration. High-quality donor screening is associated with substantial costs.
Readmission rates and risk factors for readmission after transcatheter aortic valve replacement in patients with end-stage renal disease
Authors: Park Dae Yong , An Seokyung , Hanna Jonathan M. , Wang Stephen Y. , Cruz-Solbes Ana S. , Kochar Ajar , Lowenstern Angela M. , Forrest John K. , Ahmad Yousif , Cleman Michael , Damluji Abdulla Al , Nanna Michael G. 
Published: October 2022

Objectives
We sought to examine readmission rates and predictors of hospital readmission following TAVR in patients with ESRD.

Background
End-stage renal disease (ESRD) is associated with poor outcomes following transcatheter aortic valve replacement (TAVR).

Methods
We assessed index hospitalizations for TAVR from the National Readmissions Database from 2017 to 2018 and used propensity scores to match those with and without ESRD. We compared 90-day readmission for any cause or cardiovascular cause. Length of stay (LOS), mortality, and cost were assessed for index hospitalizations and 90-day readmissions. Multivariable logistic regression was performed to identify predictors of 90-day readmission.

Results
We identified 49,172 index hospitalizations for TAVR, including 1,219 patients with ESRD (2.5%). Patient with ESRD had higher rates of all-cause readmission (34.4% vs. 19.2%, HR 1.96, 95% CI 1.68–2.30, p<0.001) and cardiovascular readmission (13.2% vs. 7.7%, HR 1.85, 95% CI 1.44–2.38, p<0.001) at 90 days. During index hospitalization, patients with ESRD had longer length of stay (mean difference 1.9 days), increased hospital cost (mean difference $42,915), and increased in-hospital mortality (2.6% vs. 0.9%). Among those readmitted within 90 days, patients with ESRD had longer LOS and increased hospital charge, but similar in-hospital mortality. Diabetes (OR 1.86, 95% CI 1.31–2.64) and chronic pulmonary disease (OR 1.51, 95% CI 1.04–2.18) were independently associated with higher odds of 90-day readmission in patients with ESRD.

Conclusion
Patients with ESRD undergoing TAVR have higher mortality and increased cost associated with their index hospitalization and are at increased risk of readmission within 90 days following TAVR.