bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development
Authors: Mau King Hang Tommy , Karimlou Donja , Barneda David , Brochard Vincent , Royer Christophe , Leeke Bryony , de Souza Roshni A. , Pailles Mélanie , Percharde Michelle , Srinivas Shankar , Jouneau Alice , Christian Mark , Azuara Véronique 
Published: July 2022

AbstractMammalian pre-implantation embryos accumulate substantial lipids, which are stored in lipid droplets (LDs). Despite the fundamental roles of lipids in many cellular functions, the significance of building-up LDs for the developing embryo remains unclear. Here we report that the accumulation and mobilization of LDs upon implantation are causal in the morphogenesis of the pluripotent epiblast and generation of the pro-amniotic cavity in mouse embryos, a critical step for all subsequent development. We show that the CIDEA protein, found abundantly in adipocytes, enhances lipid storage in blastocysts and pluripotent stem cells by promoting LD enlargement through fusion. The LD-stored lipids are mobilized into lysosomes at the onset of lumenogenesis, but without CIDEA are prematurely degraded by cytosolic lipases. Loss of lipid storage or inactivation of lipophagy leads to the aberrant formation of multiple cavities within disorganised epithelial structures. Thus, our study reveals an unexpected role for LDs in orchestrating tissue remodelling and uncovers underappreciated facets of lipid metabolism in peri-implantation development.
Vibrio cholerae O139 genomes provide a clue to why it may have failed to usher in the eighth cholera pandemic
Authors: Ramamurthy Thandavarayan , Pragasam Agila Kumari , Taylor-Brown Alyce , Will Robert C. , Vasudevan Karthick , Das Bhabatosh , Srivastava Sunil Kumar , Chowdhury Goutam , Mukhopadhyay Asish K. , Dutta Shanta , Veeraraghavan Balaji , Thomson Nicholas R. , Sharma Naresh C. , Nair Gopinath Balakrish , Takeda Yoshifumi , Ghosh Amit , Dougan Gordon , Mutreja Ankur 
Published: July 2022

AbstractCholera is a life-threatening infectious disease that remains an important public health issue in several low and middle-income countries. In 1992, a newly identified O139 Vibrio cholerae temporarily displaced the O1 serogroup. No study has been able to answer why the potential eighth cholera pandemic (8CP) causing V. cholerae O139 emerged so successfully and then died out. We conducted a genomic study, including 330 O139 isolates, covering emergence of the serogroup in 1992 through to 2015. We noted two key genomic evolutionary changes that may have been responsible for the disappearance of genetically distinct but temporally overlapping waves (A-C) of O139. Firstly, as the waves progressed, a switch from a homogenous toxin genotype in wave-A to heterogeneous genotypes. Secondly, a gradual loss of antimicrobial resistance (AMR) with the progression of waves. We hypothesize that these two changes contributed to the eventual epidemiological decline of O139.
A non-ideal solution theory for the mechanics and electrochemistry of charged membranes
Authors: Boldini Alain , Porfiri Maurizio 
Published: July 2022

AbstractUnderstanding how ions and solvent molecules migrate within charged membranes is fundamental for advancing the analysis of biological membranes and the design of energy storage and production devices. Recent efforts highlighted a significant interplay between mechanics and electrochemistry in charged membranes, calling for the development of high-fidelity models to describe their interaction. Here, we propose a continuum theory of the chemoelectromechanics of charged membranes, accounting for potentially large deformations and non-idealities of the solution permeating the membrane. We demonstrate the potential applications of our theory within the study of ionic polymer actuators. Our theory predicts sizeable effects of non-idealities and mechanical deformations, enabling insight into the role of mechanics on solute and solvent transport within charged membranes.
Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition
Authors: Menzies Stefanie K. , Dawson Charlotte A. , Crittenden Edouard , Edge Rebecca J. , Hall Steven R. , Alsolaiss Jaffer , Wilkinson Mark C. , Casewell Nicholas R. , Harrison Robert A. , Ainsworth Stuart 
Published: July 2022

AbstractAntivenom is currently the first-choice treatment for snakebite envenoming. However, only a low proportion of antivenom immunoglobulins are specific to venom toxins, resulting in poor dose efficacy and potency. We sought to investigate whether linear venom epitopes displayed on virus like particles can stimulate an antibody response capable of recognising venom toxins from diverse medically important species. Bioinformatically-designed epitopes, corresponding to predicted conserved regions of group I phospholipase A2 and three finger toxins, were engineered for display on the surface of hepatitis B core antigen virus like particles and used to immunise female CD1 mice over a 14 weeks. Antibody responses to all venom epitope virus like particles were detectable by ELISA by the end of the immunisation period, although total antibody and epitope specific antibody titres were variable against the different epitope immunogens. Immunoblots using pooled sera demonstrated recognition of various venom components in a diverse panel of six elapid venoms, representing three continents and four genera. Insufficient antibody yields precluded a thorough assessment of the neutralising ability of the generated antibodies, however we were able to test polyclonal anti-PLA2 IgG from three animals against the PLA﻿2 activity of Naja nigricollis venom, all of which showed no neutralising ability. This study demonstrates proof-of-principle that virus like particles engineered to display conserved toxin linear epitopes can elicit specific antibody responses in mice which are able to recognise a geographically broad range of elapid venoms.
Measurements of roll, steering, and the far-field wake in track cycling
Authors: Fitzgerald Shaun , Kelso Richard , Grimshaw Paul , Warr Andrew 
Published: July 2022

AbstractA series of measurements taken with two instrumented track bicycles in a velodrome are presented. The bicycle wheel speed, cadence, roll angle, steering angle, power, and airspeed are recorded. The experimentally-measured values are compared to existing theoretical models of roll and steering angles. The accuracy of the roll angle calculations is dependent on the fidelity of the modelled cyclist path and decreases for higher riding speeds. Experimental measurements of the steering angle show a reasonable agreement to theoretical calculations, albeit with reduced steering angles on the bends at higher speeds. There is also seen an increasing steering angle oscillation within each pedal cycle with increasing bicycle velocity which may influence a cyclist’s rolling resistance and the aerodynamic flow around the bicycle’s front end. Observations are made of changes in the flow field ahead of the bicycle due to the presence of other riders on the track, showing an effective tailwind of up to 0.7 m/s. The measured power shows a decrease at the bend entry due to the changing roll angle. Data presented in this paper provides new insights and can help to provide a validation of values used in existing track cycling analytic models.
A DNA barcode reference library for endemic Ponto-Caspian amphipods
Authors: Copilaş-Ciocianu Denis , Rewicz Tomasz , Sands Arthur F. , Palatov Dmitry , Marin Ivan , Arbačiauskas Kęstutis , Hebert Paul D. N. , Grabowski Michal , Audzijonyte Asta 
Published: July 2022

AbstractThe Ponto-Caspian region is an endemicity hotspot that harbours several crustacean radiations, among which amphipods are the most diverse. These poorly known species are severely threatened in their native range, while at the same time they are invading European inland waters with significant ecological consequences. A proper taxonomic knowledge of this fauna is paramount for its conservation within the native region and monitoring outside of it. Here, we assemble a DNA barcode reference library for nearly 60% of all known Ponto-Caspian amphipod species. We use several methods to define molecular operational taxonomic units (MOTUs), based on two mitochondrial markers (COI and 16S), and assess their congruence with current species-level taxonomy based on morphology. Depending on the method, we find that 54–69% of species had congruent morpho-molecular boundaries. The cases of incongruence resulted from lumping distinct morphospecies into a single MOTU (7–27%), splitting a morphospecies into several MOTUs (4–28%), or both (4–11%). MOTUs defined by distance-based methods without a priori divergence thresholds showed the highest congruence with morphological taxonomy. These results indicate that DNA barcoding is valuable for clarifying the diversity of Ponto-Caspian amphipods, but reveals that extensive work is needed to resolve taxonomic uncertainties. Our study advances the DNA barcode reference library for the European aquatic biota, paving the way towards improved taxonomic knowledge needed to enhance monitoring and conservation efforts.
Steel slag as low-cost catalyst for artificial photosynthesis to convert CO2 and water into hydrogen and methanol
Authors: Fusco Caterina , Casiello Michele , Pisani Pasquale , Monopoli Antonio , Fanelli Fiorenza , Oberhauser Werner , Attrotto Rosella , Nacci Angelo , D’Accolti Lucia 
Published: July 2022

AbstractPhotoreduction of CO2with sunlight to produce solar fuels, also named artificial photosynthesis, is considered one of the most attractive strategies to face the challenge of reducing greenhouse gases and achieving climate neutrality. Following an approach in line with the principles of the circular economy, the low-cost catalytic system (1) based on an industrial by-product such as steel slag was assessed, which was properly modified with nanostructured palladium on its surface in order to make it capable of promoting the conversion of CO2into methanol and hydrogen through a two-stage process of photoreduction and thermal conversion having formic acid as the intermediate. Notably, for the first time in the literature steel slag is used as photoreduction catalyst.
Change in the association between coffee intake and ischemic heart disease in an international ecological study from 1990 to 2018
Authors: Shirai Yoshiro , Imai Tomoko , Sezaki Ayako , Miyamoto Keiko , Kawase Fumiya , Abe Chisato , Sanada Masayo , Inden Ayaka , Kato Takumi , Suzuki-Sugihara Norie , Shimokata Hiroshi 
Published: July 2022

AbstractIn previous observational studies, the association between coffee intake and risk of cardiovascular disease has reversed from positive to negative over time. This long-term international ecological study examined whether the association between coffee intake and mortality and incidence rates of ischemic heart disease (IHD) changed between 1990 and 2018 using multiple coherent data. We obtained data on coffee intake per capita, IHD mortality and incidence rates per 100,000 population, and socioeconomic and lifestyle indicators for each country from various publicly available databases. We integrated and analyzed data from 147 countries with populations of ≥ 1 million. We employed a linear mixed model analysis to assess the association between coffee intake and IHD mortality and incidence rates by year. The mean global coffee intake increased (p < 0.001), whereas IHD mortality (p < 0.001) and incidence (p = 0.073) decreased. In all models, the interaction between coffee intake and year showed a significant inverse association for IHD mortality and incidence rates (p < 0.001 for all). The country-level association between coffee intake and IHD mortality and incidence rates between 1990 and 2018 was stronger in the negative direction.
Sound Tolerance Conditions (Hyperacusis, Misophonia, Noise Sensitivity, and Phonophobia): Definitions and Clinical Management
Authors: Henry James A. , Theodoroff Sarah M. , Edmonds Catherine , Martinez Idalisse , Myers Paula J. , Zaugg Tara L. , Goodworth Marie-Christine 
Published: July 2022

Purpose:

For some people, exposure to everyday sounds presents a significant problem. The purpose of this tutorial was to define and differentiate between the various sound tolerance conditions and to review some options for their clinical management.

Method:
We informally reviewed the literature regarding sound tolerance conditions. The terminology and definitions provided are mostly consistent with how these terms are defined. However, many inconsistencies are noted. Methods of assessment and treatment also differ, and different methodologies are briefly described.

Results:

Hyperacusis
describes physical discomfort or pain when any sound reaches a certain level of loudness that would be tolerable for most people.
Misophonia
refers to intense emotional reactions to certain sounds (often body sounds such as chewing and sniffing) that are not influenced by the perceived loudness of those sounds.
Noise sensitivity
refers to increased reactivity to sounds that may include general discomfort (annoyance or feeling overwhelmed) due to a perceived noisy environment, regardless of its loudness.
Phonophobia,
as addressed in the audiology profession, describes anticipatory fear of sound. Phonophobia is an emotional response such as anxiety and avoidance of sound due to the “fear” that sound(s) may occur that will cause a comorbid condition to get worse (e.g., tinnitus) or the sound itself will result in discomfort or pain. (Note that
phonophobia
is a term used by neurologists to describe “migraineur phonophobia”—a different condition not addressed herein.)

Conclusions:
The literature addresses sound tolerance conditions but reveals many inconsistencies, indicating lack of consensus in the field. When doing an assessment for decreased sound tolerance, it is important to define any terms used so that the patient and all health care professionals involved in the care of the patient are aligned with the goals of the treatment plan. Treatment generally involves gradual and systematic sound desensitization and counseling.

Supplemental Material:

https://doi.org/10.23641/asha.20164130
A real‐world data collection framework for a fused dataset creation for joint human and remotely operated vehicle monitoring and anomalous command detection
Authors: Elia Rafaella , Plastiras George , Pettemeridou Eva , Savva Antonis , Theocharides Theocharis 
Published: July 2022

AbstractUnmanned Remotely Operated Vehicles (ROVs) are widely used in safety‐critical missions, spanning across monitoring, surveillance, and search and rescue missions. In most cases, the human operator controls the ROV under stressful conditions and in harsh environments. The physical and mental states of the operator are vital as they may cause involuntary movements, issuing unintentional commands due to fatigue or stress. Consequently, a joint monitoring mechanism that will assess the operator's commands can be beneficial in preventing potentially catastrophic events, such as accidents. To this end, in this study, we propose a data collection framework for creating a fused dataset, consisting of data obtained from both the human operator and the ROV, and we integrate stress induction to stimulate stress and fatigue that may affect operators during missions. We optimise the dataset, which includes the operator's physiological signals and inertial measurement unit (IMU) sensor data from the ROV, using data fusion approaches and feature extraction. We evaluate the dataset through the statistical analysis, illustrating a statistical difference between data characterising normal and involuntary commands. Finally, we evaluate the optimised and original datasets over a variety of classifiers, demonstrating an accuracy of 94% and 95%, respectively.
Solutions of several theory and technique problems in high-space-resolving hotspot electron temperature diagnosis techniques in inertial confinement fusion
Authors: Ren Kuan , Yao Li , Liu Shenye , Yi Rongqing , Mu Baozhong , Zhu Jingtao , Xu Jie , Li Wenjie , Shang Wanli , Dong Jianjun , Yang Zhiwen , Zhang Xing , Cao Zhurong , Li Yulong , Xu Tao , Guan Zhanyang , Wei Huiyue , Yang Jiamin , Ding Yongkun , Zhang Baohan , Jiang Shaoen , Wang Feng 
Published: July 2022

In implosion experiments, bremsstrahlung radiation ratios of broad-energy-band x-ray emission intensities (sampled by Ross pair) and narrow-energy-band x-ray emission intensities (sampled by multilayer) are typically used to extract the hotspot electron temperature. The latter method could potentially be more accurate because it does not require any additional theoretical arithmetic. However, the boundary conditions of the energy band, drastic influence on the measured electron temperature resulting from response differences of recording devices in the energy band, evident impact from uncertainties of the detector aiming, and coordinate interrelations for the two narrow-energy-band x-ray images have not been explored. These problems should be overcome to obtain the accurate hotspot electron temperature using the narrow-energy-band x-ray emission intensities method. This study solves the problems indicated above by exploring a diagnosis technique to extract the accurate hotspot electron temperature. In particular, we determine that the effect of the response differences and uncertainties could be ignored when the width of the sampled narrow energy band is approximately ±0.5 keV in the linear spectrum response regions of the imaging plate, and the reflectivity of the multilayer is uniform and constant in that energy band and the viewing field of the detector (≥±110 µm). This study is the first to consider the linear spectrum response of the imaging plate in different energy regions, eliminating the effect of the response differences. Finally, the maximal emission intensities in the two recorded-energy-band x-ray images can be used for coordinate interrelation.
Dimensional adjectives in Nuosu Yi
Authors: Li Xiao , Liu Hongyong 
Published: July 2022

AbstractIn this paper, we discuss two types of dimensional adjectives in Nuosu Yi (Tibeto-Burman), which we refer to as Positive adjectives (PAs) and Equative Adjectives (EAs). We show that PAs and EAs are subject to different distributions in gradation structures: EAs are only admissible in gradation structures that can be associated with measure phrases, which include differential comparatives (e.g., Ayi is 2 cm taller than Aguo.) and degree questions (e.g., How tall is Ayi?). PAs are licensed elsewhere, including comparatives that do not introduce a differential (e.g., Ayi is taller than Aguo.), the intensification construction (e.g., Ayi is very tall), the superlative construction (e.g., Ayi is the tallest), etc. Assuming that measure phrases are degree-denoting expressions, we propose that the complementary distribution of PAs and EAs in Nuosu Yi is due to their different semantics: PAs are context sensitive predicates that do not introduce a degree argument (of type <e, t>), while EAs are degree predicates (of type <d, <e, t>>).
Coastal toponyms of Iran
Authors: Poshtvan Hamideh , Talebi-Dastenaei Mahnaz 
Published: July 2022

Abstract
While the domain of toponymy has great research potential, it has so far gained little attention in Iran. The present paper is a typological study on a sample group of toponyms from two different provinces of Gilan (a northern coastal province next to the Caspian Sea) and Bushehr (a southern coastal province beside the Persian Gulf) within the framework of the Australian National Placenames Survey typology proposed by Tent and Blair. The two regions in question are similar in terms of adjacency to a major water body but different in language, culture, and geography. To determine whether the Australian proposed typology is applicable to Iranian toponyms, we collected 60 coastal placenames from Gilan and Bushehr and classified them according to their Specifics and Generics based on Tent and Blair’s (2009, 2011) typology. Further, we compared placenaming motivations and processes in the two regions. The results show that although the Iranian placenames differ from the Australian ones in terms of their structure, they fit well into the typology. Water-related features are among the top motivations for local namers in both Gilan and Bushehr. Nevertheless, Bushehr namers are more motivated by natural features while those from Gilan, in most cases, are non-naturally motivated.
The name and nature of translation studies
Authors: Munday Jeremy , Vasserman Elizaveta 
Published: July 2022

AbstractJames Stratton Holmes (Iowa, 1924 – Amsterdam, 1986) is known as both a major translator/editor of poetry from Dutch (Brems and McMartin 2020,2021) and as a teacher and researcher of translation, whose professional career was centred in the Netherlands at the University of Amsterdam. He has had a long-lasting influence on the development of the field of translation as an academic subject with his landmark essay “The Name and Nature of Translation Studies”. First presented at a 1972 conference in Copenhagen, it is “generally regarded as the founding statement of the discipline” (Gentzler 2001, 93). Yet, fifty years on, how valid is that essay in today’s context? We present a review and reappraisal of the essay in the context of Holmes’ academic work as a whole and we raise a few questions about the future and history of the discipline.
Generation of stable Q-switched pulses at 1566 nm by using a segment of erbium-doped fiber as saturable absorber
Authors: Samanta Uttam Kumar , Chowdhury Sourav Das , Paul Mukul Chandra 
Published: July 2022

Abstract
In this manuscript, the performance of a passively Q-switched fiber laser has been presented, where a segment of un-pumped erbium-doped fiber (EDF) is used as the saturable absorber (SA). We have taken an erbium and ytterbium (Er/Yb) co-doped double cladding fiber as the gain media for efficient pump absorption and checked the potential of the laser by changing the length of the in-house fabricated erbium-doped fiber saturable absorber (EFSA). For a fixed length of EFSA, variation of important system parameters such as output power, repetition rate, pulse width, etc, with the change of the pump power has also been reported. The laser has delivered pulses of a minimum duration of 1.35 µs with maximum energy of 2.8 µJ. The repetition rate varies in the range from 24.8 kHz to 47 kHz with alteration of the length of the SA. The central wavelength of the output spectra is 1566 nm.
Phase behaviors of ionic liquids attributed to the dual ionic and organic nature
Authors: Tang Chenyu , Wang Yanting 
Published: July 2022

Abstract
Ionic liquids (ILs), also known as room-temperature molten salts, are solely composed of ions with melting points usually below 100 °C. Because of their low volatility and vast amounts of species, ILs can serve as ‘green solvents’ and ‘designer solvents’ to meet the requirements of various applications by fine-tuning their molecular structures. A good understanding of the phase behaviors of ILs is certainly fundamentally important in terms of their wide applications. This review intends to summarize the major conclusions so far drawn on phase behaviors of ILs by computational, theoretical, and experimental studies, illustrating the intrinsic relationship between their dual ionic and organic nature and the crystalline phases, nanoscale segregation liquid phase, IL crystal phases, as well as phase behaviors of their mixture with small organic molecules.