bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct Epithelial Cell Profiles in Normal Versus Induced-Congenital Diaphragmatic Hernia Fetal Lungs
Authors: Gonçalves Ana N. , Correia-Pinto Jorge , Nogueira-Silva Cristina 
Published: May 2022

BackgroundRecent studies identified a great diversity of cell types in precise number and position to create the architectural features of the lung that ventilation and respiration at birth depend on. With damaged respiratory function at birth, congenital diaphragmatic hernia (CDH) is one of the more severe causes of fetal lung hypoplasia with unspecified cellular dynamics.Objectives To characterize the epithelial cell tissue in hypoplastic lungs, a careful analysis regarding pulmonary morphology and epithelial cell profile was conducted from pseudoglandular-to-saccular phases in normal versus nitrofen-induced CDH rat lungs.DesignOur analysis comprises three experimental groups, control, nitrofen (NF) and CDH, in which the relative expression levels (western blot) by group and developmental stage were analyzed in whole lung. Spatiotemporal distribution (immunohistochemistry) was revealed by pulmonary structure during normal and hypoplastic fetal lung development. Surfactant protein-C (SP-C), calcitonin gene-related peptide (CGRP), clara cell secretory protein (CCSP), and forkhead box J1 (FOXJ1) were the used molecular markers for alveolar epithelial cell type 2 (AEC2), pulmonary neuroendocrine, clara, and ciliated cell profiles, respectively.ResultsGenerally, we identified an aberrant expression of SP-C, CGRP, CCSP, and FOXJ1 in nitrofen-exposed lungs. For instance, the overexpression of FOXJ1 and CGRP in primordia of bronchiole defined the pseudoglandular stage in CDH lungs, whereas the increased expression of CGRP in bronchi; FOXJ1 and CGRP in terminal bronchiole; and SP-C in BADJ classified the canalicular and saccular stages in hypoplastic lungs. We also described higher expression levels in NF than CDH or control groups for both FOXJ1 in bronchi, terminal bronchiole and BADJ at canalicular stage, and SP-C in bronchi and terminal bronchiole at canalicular and saccular stages. Finally, we report an unexpected expression of FOXJ1 in BADJ at canalicular and saccular stages, whereas the multi cilia observed in bronchi were notably absent at embryonic day 21.5 in induced-CDH lungs.ConclusionThe recognized alterations in the epithelial cell profile contribute to a better understanding of neonatal respiratory insufficiency in induced-CDH lungs and indicate a problem in the epithelial cell differentiation in hypoplastic lungs.
Case Report: Multifocal EBV-Associated Diffuse Large B-Cell Lymphoma in a Patient With 6-MP Associated Lymphopenia With TPMT Deficiency
Authors: Müller-Scholden Lara , Deinlein Frank , Eyrich Matthias , Schlegel Paul Gerhardt , Wiegering Verena , Wölfl Matthias 
Published: May 2022

IntroductionEBV associated lymphoproliferative disorders (EBV LPD) are a known complication following solid organ or hematopoietic stem cell transplantation. The disturbance of the immune system leads to a lack of control of latent EBV-infected B-cells, as control by T-cells is mandatory to prevent uninhibited cell proliferation. EBV LPD in other settings is less frequent and etiology and pathogenesis are not completely understood.Case PresentationWe present the case of an 18-year old adolescent suffering from lymphoblastic T-cell lymphoma who developed a life-threatening EBV associated B-cell lymphoma while he was under therapy with 6-MP (6- mercaptopurine). An underlying homozygous TPMT (thiopurine S-methyltransferase) deficiency with subsequent insufficient degradation of 6-MP was identified as contributory for the development of a distinct lymphopenia leading to EBV LPD. The patient was successfully treated by discontinuation of 6-MP and initiating rituximab monotherapy.DiscussionRare cases of EBV LPD during therapy with 6-MP are reported in patients with leukemia, but no data about TPMT pharmacogenomics are available. In contrast the disease development in the presented case may be explained by the iatrogenic immunosuppression in the context of TPMT deficiency. While using 6-MP testing of genetic variations is not required for every protocol, although the use of thiopurines in patients with TPMT deficiency can cause severe immunosuppression. Our case suggests that insufficient degradation of 6-MP can have significant consequences despite dose reduction.ConclusionWhen using thiopurines, TPMT genetics should be initiated and strict drug monitoring and dose adjusting must be performed by a specialized center.
Association of the Onset of Self-Feeding With Subsequent Suspected Developmental Coordination Disorder: A Prospective Cohort Study in China
Authors: Hua Jing , Williams Gareth J. , Barnett Anna L. , Zhang Jiajia , Jin Hua , Xu Manyun , Chen Juan , Zhou Yingchun , Gu Guixiong , Du Wenchong 
Published: May 2022

BackgroundSuccessful self-feeding reflects the readiness of early motor development and environmental impacts, and the onset of self-feeding as a developmental milestone might be a predictor of subsequent motor development in children. In this study, we explored the association between the onset of self-feeding and childhood risk of Developmental Coordination Disorder in children from one-child and two-child families.MethodsWe conducted a data-linkage prospective cohort study from 38 kindergartens in 6 cities in China. A total of 11,727 preschoolers aged 3–6 years old were included in the final analysis and were assessed with the Movement Assessment Battery for Children-second edition (MABC-2) Test. The information on early self-feeding onset was obtained from parents. The mixed and multi-level logistic models utilizing a random intercept were used to investigate the associations between the onset time of self-feeding and subsequent motor performance.ResultsThe results showed that, compared with those beginning self-feeding at or younger than 12 months of age, children starting self-feeding at 13–24, 25–36, and later than 36 months, showed a decrease in their total MABC-2 scores of 2.181, 3.026, and 3.874, respectively; and had an increased risk of suspected DCD by 36.0, 101.6, 102.6%, respectively; they also had 30.2, 46.6, 71.2% increased prevalence of at risk of suspected DCD, when adjusting for both child and family characteristics (each p &lt; 0.05). Significant associations were observed in fine motor, gross motor, and balance subtests (each p &lt; 0.05) in groups with a delayed onset of self-feeding. However, the strength of the associations was mitigated in the fine motor and balance subtests in children with a sibling.ConclusionThe delayed onset time of self-feeding acts as an early behavioral marker for later childhood motor impairment. Moreover, children with a sibling may benefit from additional interaction and their motor developmental pattern may be affected by the presence of a sibling.
Basal Cisternostomy for Severe TBI: Surgical Technique and Cadaveric Dissection
Authors: Giammattei L. , Starnoni D. , Messerer M. , Daniel R. T. 
Published: May 2022

IntroductionCisternostomy is emerging as a novel surgical technique in the setting of severe brain trauma. Different surgical techniques have been proposed with a variable degree of epidural bone work. We present here the surgical technique as it is currently performed in our Institution.MethodsAnatomical dissection of one adult cadaveric head, injected and non-formalin fixed was perfomed. A large right fronto-temporo-parietal craniotomy was accomplished. Extradural sphenoidal drilling till opening of the superior orbital fissure was performed. The microsurgical anatomy of basal cisternostomy was then explored.ResultsA step by step description of the surgical technique, enriched with cadaveric and intraoperative images, was made.ConclusionBasal cisternostomy is a promising surgical technique that does not necessarily include complex surgical maneuvers. Trained neurosurgeon can safely implement it in their clinical practice.
Size dependent characteristics of AlGaN-based deep ultraviolet micro-light-emitting-diodes
Authors: Yao Yifan , Li Hongjian , Li Panpan , Zollner Christian J. , Wang Michael , Iza Michael , Speck James S. , DenBaars Steven P. , Nakamura Shuji 
Published: May 2022

Abstract
AlGaN-based deep ultraviolet (DUV) micro-light-emitting diodes (μLEDs) with emission wavelengths between 277 and 304 nm with mesa dimensions down to 20 μm were fabricated. Their size-dependent electrical and optical characteristics were analyzed. At 20 A cm−2, the external quantum efficiency (EQE) increased from 2.0% to 2.3% mainly due to the improved light extraction efficiency; the forward voltage was 7.6 V in 20 μm sized μLEDs in comparison to 9.1 V in 300 μm LEDs due to better current spreading in the smaller devices. The peak EQEs of the 20 μm μLEDs were 2.5% and 4.0% for 277 and 304 nm, among the highest reported for DUV μLEDs.
Publishing and book trade bibliography in foreign countries
Authors: Senchenko Mykola 
Published: May 2022

The article considers aspects of formation and characteristics of publishing and book trade bibliography in foreign countries. Its historical experience is diverse and specific due to national conditions, but even in this diversity, the general patterns and features inherent in the publishing and book trade bibliography of many countries are clear. On the example of the history of origin, development and modern practice of publishing and book bibliography of Great Britain, the USA, Germany and France we trace both national features and regularities of the historical way and modern structure of this kind of activity.
It is emphasized that bibliographic information about publishing products is the only possible form of presenting information about the product in the book trade. Management decisions, success of commercial enterprises, profit-making, etc. depend on the rules and principles on the basis of which bibliographic information is created and disseminated. The importance of modern bibliography enhances the widespread introduction of Internet technologies, their use in the sale of books and other publishing products, the organization of virtual bookstores and more.
Possibilities of use open sources and information requests in judicial journalism
Authors: Shevchenko Zhanna 
Published: May 2022

This scientific publication is devoted to study of the following topics:
— public informational needs for the judiciary journalism;
— informing publications in the media as responses to a number of state reforms and court decisions on a number of high-profile cases; open source capabilities and information requests;
— setting new goals and partially predicting possible behavioral changes in society resulting from changes in forensic journalism.
To demonstrate the information capability of court schedules, a table is formed that includes indicators for shares in criminal, civil and administrative proceedings which have been scheduled for hearing in courts of general jurisdiction as well as indicators of judge workloads.
The study of the possibilities of open sources and information requests in forensic journalism is intended for a wider use in practice, which will increase the professional competence of journalists and discover new topics for investigative journalism, news, generation of analytical materials that will promote legal literacy among the population.
Odessa period in the creative activity of the famous Ukrainian librarian L. Khavkinа
Authors: Zhimolostnova Veronica , Lavrus Valeria 
Published: May 2022

The proposed research is substantively and conceptually related to research on the history of domestic library science and is directly devoted to the methodological and educational activities of the famous Ukrainian librarian L. Khavkinа in Odessa 1925 year. The article uses authentic materials stored in the funds of the Odessa Regional State Archive and in the funds of the Book Museum of the Odessa State Scientific Library. Among them are such unique documents as the minutes of the meetings of the presidium of the Library Association of Odessa in 1925 year, the report of the Bibinspektura on conducting a seminar with the participation of L. Khavkinа and, finally, own financial receipts made by L. Khavkinа. These documents state that the information provided during the methodological meetings by L. Khavkinа made an unforgettable impression on the Odessa library community and encouraged it to further the fruitful development of the Odessa library business and prompted the centralization of Soviet libraries in the Odessa region and further centralized exchange of methodological, scientific and educational, library and bibliographic literature and information. However, unfortunately, L. Khavkinа's stay in Odessa and holding a library seminar was accidental and took place on the recommendation of Agitprom Gubkom and the Odessa library community did not make a special professional impression on L. Khavkinа, so in the field of professional research interests of the famous librarian further was not included.
Books of Ukraine in the mirror of the state bibliography (according to materials of database of the state bibliography "Book Chronicle" 2019)
Authors: Ocheretiana Lydiіa 
Published: May 2022

The system of bibliographic information of the Book Chamber of Ukraine, based on the receipt of mandatory copies of printed materials, comprehensively covers various types of domestic printed materials and serves as an exhaustive basis for the creation and publication of state bibliographic indexes. The most important component of the current state bibliography is the "Book Chronicle", which contains comprehensive bibliographic information about books and brochures published in Ukraine from all fields of knowledge: scientific, popular science, educational, reference, religious, official, socio-political, production and practical, literary, artistic and popular publications for children and youth, etc.
Current trends in the development of the publishing industry, science and culture necessitate bibliometric analysis of the database of the state bibliography of book editions "Book Chronicle". The proposed analytical review covers the thematic distribution of publications in the database for 2019, which contains 17 634 bibliographic records, according to UDC classes.
A comparative analysis of the number of publications by sections of the UDC in order to determine the thematic focus of book publishing in Ukraine in 2019 in accordance with the branches of science. The analysis revealed that most of the records belong to classes 0, 3, 6 and 8 — 13 942 titles, or 79% of the total number of publications in 2019 — works of art and literature and books on education, law, economics, medicine, science; the remaining sections together account for less than half of all database records — 21%, or 3692 records.
EDUCATIONAL ADVANCES ACROSS ALL LANGUAGE DOMAINS: RESULTS AND EXTENSIONS FROM THE DYNAMIC TRICKY MIX MODEL
Authors: Nelson Keith E. 
Published: May 2022

This paper demonstrates how Dynamic Systems Theory (DST) can generate powerful educational interventions. Our multiple well-controlled studies include typically-developing children between 2 and 8 years of age as well as children with variations of language disorders and with ages between 4 and 12 years. Despite the wide variation in participant characteristics, we argue that our results demonstrate again and again a core conclusion: Rapid progress in language, literacy, and narrative skills only occurs when there is a favorable dynamic convergence of cognitive readiness, scaffolding partner strategies, positive emotional engagement by child and by partner, high attention, and freedom from distraction or anxiety. We term such favorable dynamic convergences Dynamic Tricky Mixes. Under such Dynamic Tricky Mix conditions children displayed significant advances in literacy, oral language, narrative, and sign language. Other labs have shown similar advances for second language learning. Moreover, and quite surprising, under rigorous equation of Learning Condition Mixes during intervention, children with prior histories of very poor learning learned at rates matching that of children with no prior learning disabilities. This result held for deaf, autistic, dyslexic, and language-delayed children. These excellent learning rates by the children with severe learning disabilities will aid in planning more ambitious reforms in the language-and literacy-facilitating procedures of educators, special educators, and speech language pathologists. In addition, across all educational domains Dynamic Tricky Mix strategies are powerful catalysts for moving any child from a "stuck" position toward truly rapid learning. We draw further implications from our rapid vocabulary acquisition intervention work with ordinary 4-year-olds. In this case we demonstrated that with twice-weekly sessions vocabulary growth across 5 months leaped forward compared with matched control children. Many children learned at the astonishing rate of 20 new lexical items per hour. By the use of pretest/posttest comparison data on cognitive processes we further demonstrate that the experimentally-caused leap in vocabulary had cascading effects on improved memory and related cognitive skills. Thus, rapid gains by the intervention children dynamically fed into their becoming better prepared for further rapid gains in language acquisition. In turn, this set of findings enriches accounts at the theoretical level of how so much language learning usually can be achieved in the preschool years. Likewise, in evolutionary terms these kinds of mutual enhancements between language progress and cognitive processing power may help elucidate periods when there are explosive rates of changes in Hominin cultures and in brain size and capacity.
ATYPICAL SOCIAL COGNITION IN BULLYING: HOW PRE-ADOLESCENTS MENTALIZE EMOTIONS
Authors: Pedditzi Maria Luisa , Fadda Roberta , Skoler Tricia Striano 
Published: May 2022

Mentalizing is a mental activity that allows perceiving human behavior in terms of mental states like emotions, beliefs, needs, feelings, and goals. A reduced mentalizing ability is a risk factor for a variety of psychological issues in the domain of interpersonal social relationships. Numerous studies indicated deficits in social cognition in bullies and victims and highlighted that, aggressive children are less accurate in identifying emotions compared to control groups. However, only a few studies investigated mentalizing abilities related to anger and happiness in pre-adolescence. Our study tries to fill this gap in the literature, by investigating possible differences in the ability to mentalize anger and happiness in bullies and victims, compared to a control group of peers. To achieve this aim, we interviewed 100 students, aged between 13 to 14 years (M = 13.48; SD=.86), attending Italian lower secondary school, and balanced by gender. We administered the Olweus questionnaires to identify bullies and victims. We also applied a narrative approach to investigate the mental state language referred to anger and happiness. The results indicated a reduced ability to mentalize anger in bullies and victims compared to the control group. The 34.6% of bullies’ responses considered anger as a mere behavioral or physical state, compared to controls (26.3%; ?2= 15.97, ? ? 0.05) who in turn considered anger as a mental state (38.6%). Also, victims were less likely to refer to anger as a mental state (12.5%) compared to the control group (38.6%; ?2= 30.72, ? ? 0.05). These results highlight that both bullies and victims seem to have difficulty in defining anger and happiness as a mental state. The results of our study point to the need to define effective intervention programs to prevent bullying by promoting appropriate mentalization of emotions in pre-adolescents. We also highlight the need to train teachers and parents about the importance of awareness of emotions to be understood as a valuable "ally" of the cognitive and social processes involved in school and family education.
SOURCES OF CHANGES IN LEADERSHIP STYLES IN HEALTHCARE IN BULGARIA DURING COVID 19 CRISIS
Authors: Mitevska Mayiana , Tsvetkova Paulina , Ntountoulaki Elitsa 
Published: May 2022

The aim of the study is to identify the content components of the leadership styles in healthcare during COVID 19 crisis. Another goal of the study is to examine the relationship between value preferences and various demographic indicators, such as gender, age, education, position in the hierarchy, length of service and place of residence. The study was conducted among 376 people between February and March 2021 during the COVID 19 crisis. The methodology of B. Bass and B. Avolio -"Multifactor Leadership Questionnaire" was applied. The instrument was standardized for Bulgarian conditions by S. Karabelyova (Karabelyova S., 2011) and it described the transforming (charismatic) leadership style, the transactional leadership style, and the avoiding (liberal) leadership style. The data was processed via the software programme SPSS - 21 and for the purpose of the analysis descriptive statistics and dispersion analysis have been made. The study assumes that if the sources of changes in leadership styles are known, activities of an organization could be optimized, and the results of their joint activities could be maximized. The data show that demographic indicators differentiate leadership styles to varying degrees.
Hadamard Diagonalizable Graphs of Order at Most 36
Authors: Breen Jane , Butler Steve , Fuentes Melissa , Lidický Bernard , Phillips Michael , Riasanovksy Alexander , Song Sung-Yell , Villagrán Ralihe , Wiseman Cedar , Zhang Xiaohong 
Published: May 2022

If the Laplacian matrix of a graph has a full set of orthogonal eigenvectors with entries $\pm1$, then the matrix formed by taking the columns as the eigenvectors is a Hadamard matrix and the graph is said to be Hadamard diagonalizable.
In this article, we prove that if $n=8k+4$ the only possible Hadamard diagonalizable graphs are $K_n$, $K_{n/2,n/2}$, $2K_{n/2}$, and $nK_1$, and we develop a computational method for determining all graphs diagonalized by a given Hadamard matrix of any order. Using these two tools, we determine and present all Hadamard diagonalizable graphs up to order 36. Note that it is not even known how many Hadamard matrices there are of order 36.
Articulatory suppression during instruction encoding impedes performance in choice reaction time tasks
Authors: van ’t Wout Félice , Jarrold Christopher 
Published: May 2022

AbstractTheories of instruction following assume that language contributes to our ability to understand and implement instructions. The two experiments reported here investigated that assumption. Participants (total N = 96) were required to learn a series of novel tasks, with each task consisting of six arbitrary stimulus-response rules. All tasks were preceded by an instruction phase (a visual depiction of the correct stimulus-response rules for each task), during which participants performed a verbal distractor task (articulatory suppression), a non-verbal distractor task (foot tapping) or no distractor task. Additionally, the duration of the instruction phase was varied so that it was either long (60 s) or short (30 s in Experiment 1, or 10 s in Experiment 2). In both experiments participants made more errors when they had performed articulatory suppression during the instruction interval, compared to the foot tapping and no distractor task conditions. Furthermore, Experiment 2 found that this detrimental effect of articulatory suppression was especially pronounced with a very short instruction duration. These findings demonstrate that language plays a crucial role in the encoding of novel task instructions, especially when instructions are encoded under time pressure.