bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revealing the illumination effect on the discharge products in high‐performance Li–O2 batteries with heterostructured photocatalysts
Authors: Gong Hao , Wang Tao , Chang Kun , Li Peng , Liu Lequan , Yu Xingyu , Gao Bin , Xue Hairong , Ma Renzhi , He Jianping , Ye Jinhua 
Published: June 2022

AbstractAprotic lithium–oxygen batteries (LOBs) have been recognized as novel energy storage devices for their outstanding specific energy density, while the large discharge/charge overpotential is a tough barrier to be overcome. Here, hetero‐structured MoS2/ZnIn2S4 nanosheets have been prepared to capture visible light and the generated charge carriers are utilized for promoting both the oxygen reduction reaction and the oxygen evolution reaction. With the light illumination in the discharge process, the abundant photo‐inspired electrons serve as the reaction sites to promote the reduction of O2 into LiO2 which is finally deposited as Li2O2. On the contrary, the generated holes in the valence band can contribute to the low oxidization potential of Li2O2 during the charge process. It delivers a low charge potential of 3.29 V, with an excellent resulting energy efficiency of 96.7%, much superior to that of 69.2% in the dark condition. It is noted that the involvement of photoelectrons has influenced the growth of Li2O2 films on the MoS2/ZnIn2S4 nanosheets through the surface‐adsorption pathway. The insights from the theoretical calculation confirm that the photoelectrons favor the absorption of LiO2 and the formation of the Li2O2 film through the surface route. Therefore, this paper provides a deeper understanding of the mechanism of photo‐inspired charge carriers in LOBs and will enable further exploration of photo‐involved energy storage systems.
Unified Approach to Diverse Fused Fragments via Catalytic Dehydrative Cyclization
Authors: Basson Ashley J. , Halcovitch Nathan R. , McLaughlin Mark G. 
Published: June 2022

AbstractA range of highly functionalized polycyclic fragments have been synthesized, employing a catalytic dehydrative cyclization. A range of nucleophiles are shown to be successful, with the reaction producing numerous high value motifs.
Synthesis of Oxygenated Sesquiterpenoids Enabled by Combining Metabolic Engineering and Visible‐Light Photocatalysis
Authors: Liu Chenguang , Cui Xiaoyi , Chen Wei , Ma Xiaoqiang , Prather Kristala J. , Zhou Kang , Wu Jie 
Published: June 2022

AbstractThe diversification of natural products to expand biologically relevant chemical space for drug discovery can be achieved by combining complementary bioprocessing and chemical transformations. Herein, genetically engineered Escherichia coli fermentation to produce amorphadiene and valencene was combined with metal‐free photocatalysis transformations to further access nootkatone, cis‐nootkatol and two hydration derivatives. In fermentation, using a closed, anaerobic condition avoided the use of organic overlay, increased the productivity, and simplified the work‐up process. Metal‐free photocatalysis hydration and allylic C−H oxidation were designed and implemented to make the whole process greener. It was shown that the anti‐Markovnikov selectivity of photocatalyzed alkene hydration could be reversed by stereo‐electronic and steric effects existing in complex natural products. The combination of bioprocessing and photocatalysis may provide an efficient and greener way to expand the chemical space for pharmaceutical, flavor and fragrance industry.
Carbon‐Supported Potassium Hydride for Efficient Low‐Temperature Desulfurization
Authors: Chang Fei , Fedorov Alexey 
Published: June 2022

AbstractThe industrial removal of organosulfur impurities from fossil fuels relies on transition‐metal‐based catalysts in harsh conditions (ca. 400 °C, up to 100 bar H2), yet desulfurization (DS) of refractory alkyl dibenzothiophenes (DBTs) remains challenging. Here, we report that carbon‐supported potassium hydride (KH/C) enables efficient DS of DBTs in mild conditions, viz. >97 % conversion of DBTs is achieved at 165 °C in 3–6 h while the yields of respective biphenyls are 84–95 % by using only 15 % excess of KH per a C−S bond. In addition, KH/C allows to lower the concentration of 4,6‐Me2DBT in the mesitylene solution from 1000 ppm to <3 ppm (165 °C, 20 h) and provides deoxygenation, denitrogenation and catalytic aromatic hydrogenation reactions. DS of various sulfur heterocycles by using KH/C, a transition‐metal‐free material based on earth abundant elements, is viable at low temperature and has prospects for the further development towards decentralized removal of organosulfur species from fossil fuels.
Adaptive inference for Bayesian network soft‐sensor in the presence of process and sensor drift
Authors: Khosbayar Anudari , Valluru Jayaram , Huang Biao 
Published: June 2022

AbstractDue to its incorporation of prior process knowledge and handling of uncertainty in a probabilistic sense, Bayesian network (BN)‐based soft‐sensors have shown significant advantages compared to conventional regression‐based soft‐sensors. In the literature, these soft‐sensors are developed under the assumption that the process is operated around certain operating points. Due to the time‐varying nature of the process, the prediction performance of the existing BN‐based soft‐sensors may deteriorate over time. To account for this, in the current work, adaptive Bayesian inference using a random walk model for both process and sensor drift is proposed. The efficacy of the proposed approaches is demonstrated through simulation and industrial case studies, and they are shown to perform better than the conventional bias updated approach.
Peptide‐Modulated pH Rhythms
Authors: Liu Mengfei , Yuan Ling , Zhu Chenghao , Pan Changwei , Gao Qingyu , Wang Hongzhang , Cheng Zhenfang , Epstein Irving R. 
Published: June 2022

AbstractMany drugs adjust and/or control the spatiotemporal dynamics of periodic processes such as heartbeat, neuronal signaling and metabolism, often by interacting with proteins or oligopeptides. Here we use a quasi‐biocompatible, non‐equilibrium pH oscillatory system as a biomimetic biological clock to study the effect of pH‐responsive peptides on rhythm dynamics. The added peptides generate feedback that can lengthen or shorten the oscillatory period during which the peptides alternate between random coil and coiled‐coil conformations. This modulation of a chemical clock supports the notion that short peptide reagents may have utility as drugs to regulate human body clocks.
Left atrial volume index and outcome after transcatheter edge‐to‐edge valve repair for secondary mitral regurgitation
Authors: Iliadis Christos , Kalbacher Daniel , Lurz Philipp , Petrescu Aniela Monica , Orban Mathias , Puscas Tania , Lupi Laura , Stazzoni Laura , Pires‐Morais Gustavo , Koell Benedikt , Besler Christian , Ruf Tobias Friedrich , Stolz Lukas , Tence Noemie , Adamo Marianna , Giannini Cristina , Guerreiro Cláudio , Hellmich Martin , Baldus Stephan , Schofer Niklas , Thiele Holger , von Bardeleben Ralph Stephan , Hausleiter Jörg , Karam Nicole , Metra Marco , Petronio Anna Sonia , Melica Bruno , Pfister Roman 
Published: June 2022

AimsTo investigate the role of left atrial volume index (LAVi) in patients with secondary mitral regurgitation (SMR) undergoing transcatheter edge‐to‐edge mitral valve repair (TEER).Methods and resultsOutcomes were evaluated in SMR patients of a European multicentre registry according to baseline LAVi. Main analysis was performed for all‐cause mortality; residual mitral regurgitation (MR) and New York Heart Association (NYHA) class improvement were analysed for patients available. A total of 1074 patients were included with a median LAVi (interquartile range) of 58 ml/m2 (46–73). Postprocedural reduction of MR grade to ≤2+ was similar across LAVi quintiles, ranging 91%–96% (p = 0.26). Symptomatic benefit (≥1 NYHA class improvement) also did not differ by LAVi quintiles (61%–68% of patients) (p = 0.66). The risk of mortality increased by 23%–42% in the four upper quintiles compared to the bottom quintile (LAVi <42 ml/m2). The hazard ratio (HR) of mortality was 1.35 (95% confidence interval [CI] 1.02–1.78, p = 0.035) associated with a LAVi >42 ml/m2, which was attenuated after multivariable adjustment (HR 1.18, 95% CI 0.83–1.67, p = 0.36). A significant interaction was found for MR severity and pulmonary hypertension, with an increased risk of death associated with enlarged LAVi in patients with inframedian effective regurgitant orifice area (HR 1.99, 95% CI 1.06–3.74, p = 0.032) and in patients with systolic pulmonary pressure ≤50 mmHg (HR 1.67, 95% CI 1.02–2.75, p = 0.042) in multivariable analysis.ConclusionProcedural success and symptomatic benefit were high throughout the whole range of LAVi. The prognostic impact of left atrial enlargement was relevant in patients with less severe SMR and without pulmonary hypertension, reinforcing the need to identify patients in the early course of backward congestion to achieve good long‐term outcome after TEER.
Catalytic Asymmetric Synthesis of 2,6‐Disubstituted Cuneanes through Enantioselective Constitutional Isomerization of 1,4‐Disubstituted Cubanes
Authors: Takebe Hiyori , Matsubara Seijiro 
Published: June 2022

Abstract2,6‐Disubstituted cuneane has potential as a p‐disubstituted benzene bioisostere and a novel chiral scaffold. It is a constitutional isomer of a 1,4‐disubstituted cubane obtained via a metal‐catalyzed skeletal rearrangement. Unlike the highly symmetrical 1,4‐disubstituted cubane, the isomerized 2,6‐disubstituted cuneane is a chiral molecule possessing C2 symmetry. Examining various chiral catalysts revealed that the Pd‐pincer catalyst provides a good asymmetric induction.
Potentiometric Study of the Growth of a Single Au Nanoparticle
Authors: Yao Zhiqi , Wu Shu , Padilla Silvas Raul , Khichoomian Nareh , Carrillo Zachary A. , Anz Samir , Sun Peng 
Published: June 2022

AbstractA single nanoparticle (NP) attached to a nanoelectrode is a very useful system in understanding the relationship between the size of nanoparticles and their electrochemical properties. In this study, a single Au NP was spontaneously formed on a Pt nanoelectrode. The potential measured on such a system can be employed to study the effect of size of an Au nanoparticle on the Nernst potential of the reaction, AuCl4− +3e → Au(s) +4Cl−. Moreover, the nucleation period and the growth period can be distinguished from the potential graph, and the nucleation rate of the spontaneously formed Au NP can be evaluated.
Bimetallic hydroxyl fluoride with high‐rate lithium storage performance: Co0.6Zn0.4(OH)F material
Authors: Liu Yicen , Zhu Bing , Liu Yan‐gai , Zhao Hang , Wang Zekun , Wu Liming , Zhang Xi , Chen Jian 
Published: June 2022

SummaryIn this study, we synthesized a bimetal hydroxyl fluoride, Co0.6Zn0.4(OH)F, with an overlapping nanoneedle structure using a simple hydrothermal method. The synthesized Co0.6Zn0.4(OH)F was used as a new electrode material to study its electrochemical performance. Because of the synergy between Co and Zn and the high ionicity of fluorides, the Co0.6Zn0.4(OH)F electrode exhibited a discharge capacity of 1355.5 mAh g−1 during the first charging and discharging cycle. After 400 cycles at a current density of 2 A g−1, the Co0.6Zn0.4(OH)F electrode showed an excellent specific capacity of 756 mAh g−1. The Co0.6Zn0.4(OH)F electrode also exhibited an excellent capacitance contribution rate, indicating good rate performance. In addition, the hydroxyl and oxygen vacancies in the electrode material promoted the lithium/dilithium reactions. Therefore, Co0.6Zn0.4(OH)F is an excellent lithium storage material with high rate; thus, it has a certain potential application value in the future.
A bright future of hydrogels in flexible batteries and Supercapacitors storage systems: A review
Authors: Parvini Elahe , Hajalilou Abdollah , Tavakoli Mahmoud 
Published: June 2022

SummaryThe next generation of IoT, IoMT, and wearable bioelectronics demands the development of a novel form of thin‐film and flexible energy storage devices that offer high energy and power densities, mechanical reliability, and biocompatibility. Hydrogels are a class of materials that can be engineered with a range of desired properties, including stretchability, ionic conductivity, biocompatibility, adhesiveness, and mechanical match with organs, as they can be designed with Young's modulus in the range of the human skin. This review covers different types of hydrogels, including biopolymer hydrogels, carbon‐based hydrogels, and self‐healing hydrogels, and presents their use in the components of supercapacitors and batteries such as electrolyte; electrode, binder, separating membrane, and current collector. We also explain how these hydrogels contribute to improved properties of the energy storage devices and include cases in which the hydrogel is used for several functions in the same device. The contribution of hydrogels in the development of flexible energy storage devices and their impact on electrochemical performance are also discussed.
Change in serial liver stiffness measurement by magnetic resonance elastography and outcomes in NAFLD
Authors: Gidener Tolga , Dierkhising Ross A. , Mara Kristin C. , Therneau Terry M. , Venkatesh Sudhakar K. , Ehman Richard L. , Yin Meng , Allen Alina M. 
Published: June 2022

Background and Aims:
The impact of disease progression in NAFLD on liver outcomes remains poorly understood. We aimed to investigate NAFLD progression using longitudinal liver stiffness measurements (LSM) by serial magnetic resonance elastography (MRE) and the association with liver outcomes.

Approach and Results:
All adult patients with NAFLD who underwent at least two serial MREs for clinical evaluation at Mayo Clinic, Rochester, between 2007 and 2019 were identified from the institutional database. Progression and regression were defined based on LSM change of 19% above or below 19% of initial LSM, respectively, based on Quantitative Imaging Biomarker Alliance consensus. The association between change in LSM and liver‐related outcomes occurring after the last MRE was examined using time‐to‐event analysis. A total of 128 participants underwent serial MREs (53% female, median age 59 years). The median time between paired MREs was 3.4 (range 1–10.7) years. NAFLD progression (LSM = +0.61 kPa/year) was identified in 17 patients (13.3%). NAFLD regression (−0.40 kPa/year) occurred in 35 patients (27.3%). Stable LSM was noted in 76 participants (59.4%). In NAFLD without cirrhosis at baseline (n = 75), cirrhosis development occurred in 14% of LSM progressors and 2.9% of non‐progressors (p = 0.059) over a median 2.7 years of follow‐up from the last MRE. Among those with compensated cirrhosis at baseline MRE (n = 29), decompensation or death occurred in 100% of LSM progressors and 19% of non‐progressors (p < 0.001) over a median 2.5 years of follow‐up after the last MRE.

Conclusions:
Noninvasive monitoring of LSM by conventional MRE is a promising method of longitudinal NAFLD monitoring and risk estimation of liver‐related outcomes in NAFLD.
GCKIII kinases in lipotoxicity: Roles in NAFLD and beyond
Authors: Mahlapuu Margit , Caputo Mara , Xia Ying , Cansby Emmelie 
Published: June 2022

Abstract
Nonalcoholic fatty liver disease (NAFLD) is defined by excessive accumulation of lipid droplets within hepatocytes. The STE20‐type kinases comprising the germinal center kinase III (GCKIII) subfamily – MST3, MST4, and STK25 – decorate intrahepatocellular lipid droplets and have recently emerged as critical regulators of the initiation and progression of NAFLD. While significant advancement has been made toward deciphering the role of GCKIII kinases in hepatic fat accumulation (i.e., steatosis) as well as the aggravation of NAFLD into its severe form nonalcoholic steatohepatitis (NASH), much remains to be resolved. This review provides a brief overview of the recent studies in patient cohorts, cultured human cells, and mouse models, which have characterized the function of MST3, MST4, and STK25 in the regulation of hepatic lipid accretion, meta‐inflammation, and associated cell damage in the context of NAFLD/NASH. We also highlight the conflicting data and emphasize future research directions that are needed to advance our understanding of GCKIII kinases as potential targets in the therapy of NAFLD and its comorbidities. Conclusions: Several lines of evidence suggest that GCKIII proteins govern the susceptibility to hepatic lipotoxicity and that pharmacological inhibition of these kinases could mitigate NAFLD development and aggravation. Comprehensive characterization of the molecular mode‐of‐action of MST3, MST4, and STK25 in hepatocytes as well as extrahepatic tissues is important, especially in relation to their impact on carcinogenesis, to fully understand the efficacy as well as safety of GCKIII antagonism.
Evaluation of a nutrition education resource for refugees and newly arrived migrants to Australia
Authors: Mead Courtney , Tindall Robyn , Charlton Karen 
Published: June 2022

AbstractIssued addressedTo assess the impact of a multi‐lingual education video on the healthy eating knowledge of individuals in refugee and newly arrived migrant community groups.MethodsA mixed methods, pre‐ and post‐test study design was used. Participants completed a verbal questionnaire with pictorial answer sheets prior to and immediately after viewing one chapter of a healthy eating video. Qualitative data was obtained through semi‐structured, focus group discussions following the video viewing. Eighty‐six participants were recruited via convenience sampling through refugee community organisations in the Illawarra Shoalhaven, South Western Sydney and Northern Sydney Local Health Districts. Study participants self‐selected to attend Arabic (n = 17), Dari (n = 12), Karen (n = 32) or Tibetan (n = 25) sessions.ResultsIn 85 participants with pre‐post results, there was a significant improvement in healthy eating knowledge after viewing the video (mean score 61% [SD 23.2] vs 75% [SD 24.2]; [P < .05]). Increased mean scores were observed in all language groups except the Karen‐speaking group. Focus group responses indicated the video improved food literacy, particularly in the areas of food safety, fruit and vegetable consumption, label reading, writing a shopping list and decreasing intake of sugary drinks.ConclusionThe video improved healthy eating knowledge of individuals in refugee and newly‐arrived migrant community groups.So what?There is potential for these nutrition education resources to inform and educate newly arrived refugees and migrants to Australia about healthy eating practices, however, future research is required to determine their effect on actual behaviour change.
Spatial prioritization of tomato cultivation based on water footprint, land productivity, and economic indices
Authors: Bazarfshan Ommolbanin , Yahyazadeh Mehrnaz , Jamshidi Sajad , Zamani Hossein 
Published: June 2022

AbstractIn this study, the water footprint (WF) and its components, the water footprint economic value (WFEV), and the economic land productivity (ELP) for tomato cultivation in Iran were determined. These data were used in a multicriteria decision‐making tool (PROMETTEE II) to prioritize tomato production in more agriculturally sustainable regions of the country. The results indicate that the average WF of tomato production in Iran on a national scale is 327.2 m3/t, with a WFEV of 0.49 USD/m3 and an ELP of 3611.31 USD/ha. The green WF of tomato production ranged from 1.5 to 38.8 (average 15) m3/t, the blue WF ranged from 46.2 to 638 (average 273.3) m3/t, and the grey WF ranged from 86.8 to 771.6 (average 327.2) m3/t. Comparing the WFEV, ELP, and WF of tomatoes with 30 major agricultural products in Iran shows that this product holds a higher cultivation priority than grains and cereals. Based on the resulting WF and economic evaluations, the tomato growing areas are classified into eight clusters, from the most to least suitable for growing tomatoes.
Forecasting Commodity Market Returns Volatility: A Hybrid Ensemble Learning GARCH‐LSTM based Approach
Authors: Kakade Kshitij , Mishra Aswini Kumar , Ghate Kshitish , Gupta Shivang 
Published: June 2022

SummaryThis study investigates the advantage of combining the forecasting abilities of multiple generalized autoregressive conditional heteroscedasticity (GARCH)‐type models, such as the standard GARCH (GARCH), exponential GARCH (eGARCH), and threshold GARCH (tGARCH) models with advanced deep learning methods to predict the volatility of five important metals (nickel, copper, tin, lead, and gold) in the Indian commodity market. This paper proposes integrating the forecasts of one to three GARCH‐type models into an ensemble learning‐based hybrid long short‐term memory (LSTM) model to forecast commodity price volatility. We further evaluate the forecasting performance of these models for standalone LSTM and GARCH‐type models using the root mean squared error, mean absolute error, and mean fundamental percentage error. The results highlight that combining the information from the forecasts of multiple GARCH types into a hybrid LSTM model leads to superior volatility forecasting capability. The SET‐LSTM, which represents the model that combines forecasts of the GARCH, eGARCH, and tGARCH into the LSTM hybrid, has shown the best overall results for all metals, barring a few exceptions. Moreover, the equivalence of forecasting accuracy is tested using the Diebold–Mariano and Wilcoxon signed‐rank tests.
A call to action from the Purdue University Center for Health Equity and Innovation
Authors: Gonzalvo Jasmine D. , Meredith Ashley , Adeoye‐Olatunde Omolola , Kimiecik Carlyn , Pastakia Sonak , Rodriguez Natalia , Ruiz Yumary , Ott Carol , Schellhase Ellen , Crawford Elizabeth , Crowe Susie , Samuel Jeffrey , Conklin Megan , Adams Jerome , Karwa Rakhi 
Published: June 2022

AbstractThe Purdue University College of Pharmacy established the Center for Health Equity and Innovation (CHEqI) to provide students, faculty, and internal and external partners with a coordinating center whose primary purpose is to address inequities in the social determinants of health. Through this article the development of the center, the interdisciplinary activities the center is currently engaged in, ongoing educational efforts to provide instruction related to equity, and research endeavors designed to better understand the impact of our efforts are described. Pharmacists and colleges/schools of pharmacy must optimize health equity efforts with interdisciplinary partners by: (1) providing student opportunities to learn about diverse populations through engagement and integration with communities, (2) encouraging students to identify and lead health equity initiatives, (3) incorporating health equity engagement and track impact of efforts designed to address inequity into annual review and promotion processes, (4) creating and participating in health equity training opportunities, and (5) developing a formal structure for collaborative networks to align health equity efforts. These five strategies and examples are not intended to be prescriptive, but rather, an opportunity to synergize and cultivate further discussion of work in health equity across colleges/schools of pharmacy.