bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine-Learning based process monitoring of automated composites manufacturing to enable digital twin development
Authors: Mujtaba Ahmed , Islam Faisal , Kaeding Patrick , Lindemann Thomas , Prusty B. Gangadhara 
Published: November 2022

Abstract
Automated fibre placement (AFP) is an advanced robotic manufacturing technique which can overcome the challenges of traditional composite manufacturing. The interlaminar strength of AFP-manufactured composites depends on the in-situ thermal history during manufacturing. The thermal history is controlled by the choice of processing conditions and improper interfacial temperatures may result in insufficient bonding. Being able to better predict such maintenance issues in real-time is an important focus of smart manufacturing and Industry 4.0 to improve manufacturing operations. This study focuses on developing a digital tool for process monitoring which integrates the physical and digital space of the AFP process. The digital tool constitutes a machine learning model to predict the in-situ thermal history during AFP manufacturing. The predicted thermal history can be compared with the real-time in-situ temperatures during manufacturing to predict the quality of the layup. A GUI application is developed to provide benchmarking data for comparison with real-time temperatures during manufacturing enabling monitoring and predictive maintenance of the AFP process paving way for the development of a digital twin of the AFP composites manufacturing process.
Use of Stochastic Finite Fault Simulation Method for a Target Mw=5.5 event, 2016 Kumamoto foreshock (Mw=6.5) and mainshock (Mw=7.0) at ESG6 – Blind Trial Sites
Authors: Askan Aysegul , Karimzadeh Shaghayegh , Asten Michael 
Published: November 2022

AbstractIn this study, the authors aim to test practical simulations with the stochastic finite-fault method with a dynamic corner frequency for ground motion simulation at the SEVO and KUMA stations for the earthquakes listed by the ESG6 – Blind Trial Step 2 and 3 (BP2 and BP3) Working Group. The Step 2 exercise includes simulation of an Mw = 5.5 event while Step 3 involves simulation of 2016 Kumamoto foreshock (Mw = 6.5) and Kumamoto mainshock (Mw = 7.0). After validation at the reference station SEVO for Mw = 5.5 event, the ground motion at KUMA station is amplified in the frequency domain by generic site amplification factors using the site class NEHRP-D according to the Vs30 value computed on the 1D soil model established for the Step 1 result at KUMA. In Step 3, the same simulation method is used for ground motion simulation of the 2016 Kumamoto foreshock (Mw = 6.5) and mainshock (Mw = 7.0) at SEVO and KUMA stations. For both of these events, after validation at station SEVO, the hard rock ground motion at KUMA is simulated and then propagated through the 1D soil model established for KUMA, with an equivalent linear approach. The results prove that use of local earth models to model site amplifications along with well-defined source and path parameters in ground motion simulations yield accurate simulated motions.
Multi-omics analysis reveals changes in tryptophan and cholesterol metabolism before and after sexual maturation in captive macaques
Authors: Liu Xu , Liu Xuyuan , Wang Xinqi , Shang Ke , Li Jiawei , Lan Yue , Wang Jiao , Li Jing , Yue Bisong , He Miao , Fan Zhenxin 
Published: November 2022

Abstract
Rhesus macaques (Macaca mulatta, RMs) are widely used in sexual maturation studies due to their high genetic and physiological similarity to humans. However, judging sexual maturity in captive RMs based on blood physiological indicators, female menstruation, and male ejaculation behavior can be inaccurate. Here, we explored changes in RMs before and after sexual maturation based on multi-omics analysis and identified markers for determining sexual maturity. We found that differentially expressed microbiota, metabolites, and genes before and after sexual maturation showed many potential correlations. Specifically, genes involved in spermatogenesis (TSSK2, HSP90AA1, SOX5, SPAG16, and SPATC1) were up-regulated in male macaques, and significant changes in genes (CD36), metabolites (cholesterol, 7-ketolithocholic acid, and 12-ketolithocholic acid), and microbiota (Lactobacillus) related to cholesterol metabolism were also found, suggesting the sexually mature males have stronger sperm fertility and cholesterol metabolism compared to sexually immature males. In female macaques, most differences before and after sexual maturity were related to tryptophan metabolism, including changes in IDO1, IDO2, IFNGR2, IL1Β, IL10, L-tryptophan, kynurenic acid (KA), indole-3-acetic acid (IAA), indoleacetaldehyde, and Bifidobacteria, indicating that sexually mature females exhibit stronger neuromodulation and intestinal immunity than sexually immature females. Cholesterol metabolism-related changes (CD36, 7-ketolithocholic acid, 12-ketolithocholic acid) were also observed in female and male macaques. We explored changes before and after sexual maturation through a multi-omics approach and identified potential biomarkers for judging sexual maturity in RMs, including Lactobacillus (for males) and Bifidobacterium (for females), which is valuable for RM breeding and sexual maturation research.
A new family of sulfamidophosphonates derivatives: Microwave-accelerated multicomponent synthesis, characterization and X-Ray Crystallographic Study.
Authors: GHODBANE Racha , K'TIR Hacène , BOUACIDA sofiane , ibrahim-ouali malika , aouf zineb , aouf nour-eddine 
Published: November 2022

AbstractIn this present study we describe a simple, effective and greener one-pot microwave-assisted synthesis of novel α-sulfamidophosphonates4(a-n)that were rationally designed and synthesized following the principle of the superposition of bioactive substructures. This reaction was accomplished by the condensation of various aromatic aldehydes, sulfamide and diethyl phosphiteviaKabachnik-Fields reaction using ethanol as solvent under catalyst-free condition. The corresponding products were obtained with good yield, in short reaction time and no side product was observed. All the newly synthesized compounds were systematically characterized byIR,1H NMR,13C NMRand31P NMRanalysis and the structures of the compounds4band4cwere further analyzed by single crystal X-ray diffraction.
Different cold tolerances among three strains of large yellow croaker: related to antioxidant defense and energy metabolism
Authors: Zeng Lin , Wang Yong-Hong , Ai Chun-Xiang , Zhang Hui , Huang Yu-Cong , Zou Wei-Guang 
Published: November 2022

Abstract
The aim of this study was to compare low-temperature tolerances in different strains of large yellow croaker. Dai Qu (DQ), Min-Yue Dong (MY) and Quan Zhou (NZ) strains of large yellow croaker were subjected to cold stress (8.6°C) for 12h, 24h, 48h and 96h. Survival rate, histological observation, antioxidant and energy metabolism indicators were determined. The results showed that compared with DQ group and MY group, NZ group aggravated hepatic structure, enhanced ROS, lactate and anaerobic metabolism (PK gene expression and activity), while inhibited ATP, GSH, antioxidant enzymes (mRNA levels and activities of SOD, GPx and CAT) and aerobic metabolism enzymes (mRNA levels and activities of F-ATPase, SDH and MDH), indicating the reduction of cold tolerance in NZ group was closely correlated with the decrement of antioxidative capacity and energy metabolism efficiency. Nrf2 and AMPK gene expressions were correlated with antioxidant and energy metabolism mRNA levels, respectively, suggesting Nrf2 and AMPK might participate in the modulation of target genes during the cold-stress adaptation. In conclusion, low temperature tolerance of fish depended on the antioxidant defense and energy metabolism efficiency, which contributes to understanding the underlying mechanisms of cold adaptation in large yellow croaker.
Large silicic magma chambers at the Moho depth characterize the multi-level plumbing system of back-arc spreading ridge
Authors: Gennaro Emanuela , Iezzi Gianluca , Cocchi Luca , Ventura Guido 
Published: November 2022

Abstract
The plumbing system of volcanoes in crustal convergent settings consists of vertically superimposed, sill-like reservoirs filled by less dense and SiO2-richer magmas moving upward. The plumbing systems of spreading ridges is supposed to be simpler and characterized by prevailing sub-parallel dikes. Here, we present the results of thermo-barometric determinations from minerals and modeling of field potential data at the Marsili spreading ridge in the Southern Tyrrhenian Sea back-arc oceanic basin. The Marsili plumbing system consists of sill-like, large SiO2-rich magma reservoirs located at the Moho depth and sub-vertical basaltic dikes crossing the whole oceanic crust. The formation of deep-seated silicic reservoirs is associated with a decrease in the back-arc spreading rate. The geometry of the plumbing system of spreading ridges may be not dissimilar from that of volcanoes at convergent margins.
Effect of Systemic Teriparatide (PTH1-34) versus Placebo on Bone MineralDensity (BMD) after Lumbar Spinal Arthrodesis: A Secondary Analysis of aRandomized Clinical Trial
Authors: Gimbel Astrid , Andersen Mikkel Ø. , Hermann Pernille , Jespersen Annette B. , Carreon Leah Y. 
Published: November 2022

Abstract
Background
The present study is a secondary analysis of data from a randomized, double-blind, placebo controlled clinical trial. Patients undergoing decompression and non-instrumented lumbar arthrodesis may have initial bone loss after surgery, increasing their fracture risk. The aim of this analysis is to determine whether short term systemic Teriparatide has a beneficial effect on Bone Mineral Density (BMD) in patients 60 years and older undergoing non-instrumented lumbar arthrodesis.
Method
Patients were 87 Danish patients eligible for spinal decompression and non-instrumented arthrodesis, who received either 20 micrograms Teriparatide (N=43) or placebo (N=44) daily for 3 months starting prior to surgery. Randomization and allocation were computer-generated. Outcome measures were BMD and Patient reported Outcome measures (PROs) containing Oswestry Disability Index (ODI) and Visual Analog Scale (VAS) for leg pain. DXA scans were performed preoperatively and at 1,3,6 and 12 months after surgery. PROs were collected at the same time points aside at 1 month after surgery. ANCOVA comparing Lumbar Spine BMD and Hip BMD in Teriparatide vs Placebo with gender, weight, age and baseline BMD as covariates were performed.
Results
There was some improvement in BMD in the Teriparatide group compared to placebo at 3 months after surgery, but not sustained at 6 and 12 months. There was a loss of Lumbar Spine BMD at 1 month after surgery in both groups.
Conclusion
Systemic Teriparatide provided a short term beneficial effect on BMD compared to placebo in patients undergoing decompression and non instrumented lumbar arthrodesis. There was an initial rapid bone loss 1 month after surgery in both groups.
Deep learning-based prediction of mandibular growth trend in children with anterior crossbite using cephalometric radiographs
Authors: Zhang Jia-Nan , Lu Hai-Ping , Hou Jia , Wang Qiong , Yu Feng-Yang , Zhong Chong , Huang Cheng-Yi , Chen Si 
Published: November 2022

Abstract
Background
It is difficult for orthodontists to accurately predict the growth trend of the mandible in children with anterior crossbite. This study aims to develop a deep learning model to automatically predict the mandibular growth result into normal or overdeveloped using cephalometric radiographs.
Methods
A deep convolutional neural network (CNN) model was constructed based on the algorithm ResNet50 and trained on the basis of 256 cephalometric radiographs. The prediction behavior of the model was tested on 40 cephalograms and visualized by equipped with Grad-CAM. The prediction performance of the CNN model was compared with that of three junior orthodontists.
Results
The deep-learning model showed a good prediction accuracy about 85%, much higher when compared with the 54.2% of the junior orthodontists. The sensitivity and specificity of the model was 0.95 and 0.75 respectively, higher than that of the junior orthodontists (0.62 and 0.47 respectively). The area under the curve (AUC) value of the deep-learning model was 0.9775. Visual inspection showed that the model mainly focused on the characteristics of special regions including chin, lower edge of the mandible, incisor teeth, airway and condyle to conduct the prediction.
Conclusions
The deep-learning CNN model could predict the growth trend of the mandible in anterior crossbite children with relatively high accuracy using cephalometric images. The prediction decision was made by a direct and comprehensive detecting and analyzing system instead of doctor’s opinion from clinical experience.
Isolation and characterization of Plant Growth-Promoting Rhizobacteria from Cenchrus fungigraminus and their potential role in plant growth promotion
Authors: Jing Li , Zhou Bingxin , Li Tingting , Lin Hui , Lin Zhanxi , Lu Guodong , Liu Yanling , Lin Biaosheng , Lin Dongmei 
Published: November 2022

Abstract

Aims To understand the species composition, the relative content, and diversity of nitrogen fixing bacteria inCenchrus fungigraminusrhizophere, and to screen nitrogen-fixing bacteria to study their potential role in plant growth promotion. Methods Soil samples were collected from 4 depth (G1, G2, G3 and G4) ofC. fungigraminusrhizophere and physical and chemical properties were determined. The diversity and abundance of nitrogen-fixing bacteria andnifH gene copy were analyzed. Nitrogen-fixing bacteria were screened and selected for studying theC. fungigraminusseedlings growth promotion. Results The highest diversity and abundance of nitrogen-fixing bacteria were observed inC. fungigraminusrhizosphere (G2), which mainly included Proteobacteria (93.91%), Actinobacteria (0.42%), Firmicutes (0.18%) and significantly effected by total nitrogen, available nitrogen and depth. ThenifH gene copy was also highest (1.56 ± 0.17×107copies/g) in G2.Rhizobium pusenseNO.8 and NO.28 were isolated in G1 and G2, respectively, with nitrogenase activity of 1.45 ± 0.04 and 2.00 ± 0.07 U/g. The promotion experiment revealed that plant height, root length, leaf length ofC. fungigramminusseedlings treated with both strains were significantly increased 56.79%, 76.99% and 55.71%, and significantly increased on moisture and total nitrogen of planting soil compare with control (P < 0.05). The available nitrogen, organic matter and organic carbon in soil withR. pusenseNO.28 have significantly increased 3.09, 5.77 and 5.77 times. Conclusion Nitrogen-fixing bacteria inC. fungigraminusrhizosphere soil is rich and play a significant role in promoting its seedlings growth. The study provides the development of PGPRs fromC. fungigraminusrhizosphere to be biological fertilizers.
The Wakayama earthquake swarm in Japan
Authors: Nakajima Junichi 
Published: November 2022

Abstract
An earthquake swarm in the Wakayama prefecture, Japan, is known as the most active and persistent swarm, with ~ 100,000 earthquakes occurring during the 2003–2020 period. However, no systematic studies have highlighted the source of this intriguing non-volcanic earthquake swarm to date. In this study, we systematically investigate the temporal and spatial evolution of the Wakayama earthquake swarm and estimate the seismic velocity structure around the Kii peninsula, where there are series of anomalous geophysical and geochemical signatures, such as high 3He/4He ratios, deep low-frequency earthquakes that occur far from active volcanoes, and hot springs with high salinity and solute concentrations. We reveal that seismicity associated with the Wakayama earthquake swarm occurs almost evenly in both time and space, and that the majority of the earthquakes occur along well-defined planes that dip to the west at 30–45º. Although the focal depths of the earthquakes in the swarm are 5–10 km shallower than those for the surrounding crustal earthquakes, b value (0.96) of the earthquake swarm is not distinct from the surrounding earthquakes. The seismic tomography results reveal the presence of an inclined low-velocity anomaly beneath the Wakayama swarm that is sandwiched by high-velocity, impermeable materials on both sides in the subduction direction. This unique tectonic setting controls a pathway that facilitates the upward migration of slab-derived fluids, with the high fluid concentration in this inclined low-velocity zone interpreted as a permeable zone. Therefore, we infer that the location of the Wakayama swarm is controlled by structural heterogeneities in the crust. This study further suggests that the anomalous geophysical and geochemical signatures observed across the Kii peninsula can be explained by the upward migration of the slab-derived fluids, with these varying signatures that are caused by the fluid migration pathways to the surface.
Impact of cranial bone-derived mesenchymal stem cell transplantation for functional recovery in experimental spinal cord injury
Authors: Shimizu Kiyoharu , Maeda Yuyo , Kuwabara Masashi , Hosogai Masahiro , Mitsuhara Takafumi , Takeda Masaaki , Yuge Louis , Horie Nobutaka 
Published: November 2022

Abstract
Impairments of the central nervous system, such as in stroke, brain trauma, and spinal cord injury (SCI), cannot be reversed using current treatment options. This study compared the therapeutic effects and underlying mechanisms of transplanted rat cranial bone-derived mesenchymal stem cells (rcMSCs) and rat bone marrow-derived mesenchymal stem cells (rbMSCs) in a rat model of cervical SCI (cSCI). Rats were intravenously administered rcMSCs, rbMSCs, or phosphate-buffered saline (control) 24 h after undergoing cSCI. The rcMSC-treated group showed improved functional recovery over the rbMSC-treated and control groups, as well as reduced lesion volume compared to the control group. mRNA expression levels of transforming growth factor-β, tumor necrosis factor-α, and nitric oxide synthase 2 at the spinal cord lesion site were significantly higher in the rcMSC-treated group than in the control and rbMSCs-treated groups. Comprehensive comparative bioinformatics analysis of rcMSC and rbMSC RNA sequencing results indicated that genes associated with leukocyte transendothelial migration and chemokine signaling were significantly downregulated in rcMSCs. The study findings demonstrate that rcMSCs have more potent anti-inflammatory effects than rbMSCs, likely induced by inhibiting neutrophil migration and suppressing chemokine expression, thereby leading to improved functional recovery in cSCI model rats.
The Effect of Adding Different Doses of Exercise Training to a Diet-Induced Weight Loss on Beta-Cell Function in Persons with Newly Diagnosed Type 2 Diabetes: Primary Findings from the DOSE-EX Multi-Arm, Parallel-Group, Randomized Trial
Authors: Ried-Larsen Mathias , Legaard Grit , Lyngbaek Mark , Almdal Thomas , Karstoft Kristian , Bennetsen Sebastian , Feineis Camilla , Nielsen Nina , Durrer Cody , Liebetrau Benedikte , Nystrup Ulrikke , Østergaard Martin , Thomsen Katja , Trinh Becky , Solomon Thomas , Hall Gerrit van , Brønd Jan , Holst Jens , Hatmann Bolette , Christensen Robin , Pedersen Bente 
Published: November 2022

Abstract
Diet-induced weight loss improves beta-cell function in persons with type 2 diabetes (T2D) with remaining secretory capacity. It is unknown if adding exercise to a diet-induced weight loss improves beta-cell function and if exercise volume is important for improving beta-cell function in this context.
In this four-armed randomized trial (Clinicaltrials.gov NCT03769883) 82 persons (35% females, mean age (SD) of 58.2 (9.8) years) with newly diagnosed T2D (<7 years) were randomly allocated to standard care (N=21), calorie restriction (25% energy reduction; N=20), calorie restriction and exercise 3 times per week (N=20) or calorie restriction and exercise 6 times per week (N=21) for 16 weeks. We determined beta-cell function by calculating the disposition index (insulin secretion multiplied by insulin sensitivity), during the first stage of a 3-stage hyperglycemic clamp technique (primary outcome) and based on a liquid mixed meal tolerance test (MMTT). Glucagon-like peptide-1 and arginine was infused during the 2nd and 3rd stage of the clamp, respectively.
The beta-cell function during the clamp increased more in all three intervention groups compared to standard care (diet control group (DCON), 58%; 95% confidence intervals [CI] 16 to 116; moderate exercise dose group (MED) 105%; 95% CI, 49 to 182 and high exercise dose group (HED), 137%; 95% CI, 73 to 225) and followed a linear dose-response relationship (p<0.001 for trend). The beta-cell function during the MMTT also increased more in all three intervention groups compared to standard care (DCON, 87%; 95% CI 40 to 148; MED 133%; 95% CI, 73 to 213 and HED, 141%; 95% CI, 80 to 223) but with no linear dose-response improvement. Glucagon-like peptide-1 infusion increased insulin secretion more in all interventions (p≤0.001 for differences to CON) but only MED was associated with higher mean insulin secretion compared to DCON (p=0.045).
Adding an exercise intervention to a diet-induced weight loss improves glucose stimulated beta-cell function in newly diagnosed persons with T2D in an exercise dose-dependent manner. However, when the beta-cell function was assessed during a MMTT, no consistent evidence of additional improvements in beta-cell function was observed when increasing exercise dose from 3 to 6 times per week.
Cancer Patients’ Health Related Quality of Life (HRQoL) and Its Predictor Factors during the COVID-19 Pandemic: A Cross-sectional Survey Study in China
Authors: Sun Lingyun , Peng Rongyan , Liu Jiaxi , Yan Yunzi , Zhang Haibo , Yang Yufei 
Published: November 2022

Abstract
Objective
To evaluate Chinese cancer patients’ health related quality of life and its predictor factors during the COVID-19 pandemic.
Method
We conducted an online cross-sectional survey study among Chinese cancer patients in 2020 around China by utilizing the validated Mandarin version of COVID-19 IHRQOL questionnaire.
Results
387 patients participated in this survey, in which 283(72.9%) patients worried the pandemic’s impact on their cancer care, 69% feared getting infected by COVID-19. 30.7% and 17.3% patients had experienced depression and social isolation. More than 80% patients reported perceived benefits such as feeling more grateful. 26.3% patients reported financial hardship and 44.9% reported cancer care disruption. Multivariate analyses showed that more financial hardship was significantly associated with higher level of COVID-19 specific distress (p < 0.001).
Conclusion
Addressing health care services disruption and financial hardship, as well as promoting functional social support might help Chinese cancer patients acquire better HRQoL during the pandemic.