bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sevoflurane Ameliorates Schizophrenia in a Mouse Model and Patients: A
Pre-Clinical and Clinical Feasibility Study
Authors: Lin Chuansong , Ma Daqing , Song Xingrong , Zhao Tianyun , Shi Ziwen , Ling Nongxi , Qin Jingwen , Zhou Quancai , Wu Lingzhi , Wang Yuansheng 
Published: March 2022

Background:
GABAergic deficits have been considered to be associated with the pathophysiology
of schizophrenia, and hence, GABA receptors subtype A (GABAARs) modulators, such
as commonly used volatile anesthetic sevoflurane, may have therapeutic values for schizophrenia.
The present study investigates the therapeutic effectiveness of low-concentration sevoflurane in
MK801-induced schizophrenia-like mice and schizophrenia patients.

Methods:
Three weeks after MK801 administration (0.5 mg kg-1, i.p. twice a day for 5 days), mice
were exposed to 1% sevoflurane 1hr/day for 5 days. Behavioral tests, immunohistochemical analysis,
western blot assay, and electrophysiology assessments were performed 1-week post-exposure.
Ten schizophrenia patients received 1% sevoflurane 5 hrs per day for 6 days and were assessed with
the Positive and Negative Syndrome Scale (PANSS) and the 18-item Brief Psychiatric Rating Scale
(BPRS-18) at week 1 and week 2.

Results:
MK801 induced hypolocomotion and social deficits, downregulated expression of
NMDARs subunits and postsynaptic density protein 95 (PSD95), reduced parvalbumin - and
GAD67-positive neurons, altered amplitude and frequency of mEPSCs and mIPSCs, and increased
the excitation/inhibition ratio. All these changes induced by MK-801 were attenuated by sevoflurane
administration. Six and eight patients achieved a response defined as a reduction of at least 30% in
the PANSS total score at 1st and 2nd week after treatments. The BPRS-18 total score was found to be
significantly decreased by 38% at the 2nd week (p < 0.01).

Conclusion:
Low-concentration sevoflurane effectively reversed MK801-induced schizophrenialike
disease in mice and alleviated schizophrenia patients’ symptoms. Our work suggests sevoflurane
to be a valuable therapeutic strategy for treating schizophrenia patients.
ModK: Formula for Determining the Best Season and Career of a Football Player by Objective Indicators
Authors: Salvador Emanuel Pericles , de Menezes Santos Denilson , Bezerra Sonny Allan Silva 
Published: March 2022

Introduction:
Football is a team sport, but the idol or best football player of the moment or any time is a common pursuit within the sports community. Different strategies are applied in order to find out the top player. The aim of this study is to introduce an objective proposal for the career measurement of football players.

Methods:
A total of 50 players ranked the best of the 21st century, and 14, ranked the best of the 19/20 season of European and world football, had their careers and seasons measured through a formula named ModK. Descriptive statistics characterized the careers and seasons. The Pearson's Correlation Coefficient test was used for the variables used in the formula with the reference ranking, and ModK was performed to measure the strength of association of the rankings.

Results:
The values of the scores obtained by the ModK formula showed moderate correlation (r=0,416) with the reference ranking. All variables used in the formula showed higher correlations with the ranking Modk formula when compared to the reference ranking.

Conclusion:
The ModK formula is proven to be effective in evaluating the career or full season of football athletes in an exclusively objective manner, presenting an acceptable correlation with a ranking created by experts.
Analysis of Cadmium Metal in Facial Moisturizing Cream with Atomic Absorbtion Spectrophotometry Method
Authors: Ardhya Hilda , Wardah Annisa Chiyarotul , Rachmawati Pipit 
Published: March 2022

This study aims to determine the concentration of cadmium (Cd) metal content in various facial moisturizing creams with atomic absorbtion spectrophotometry (AAS). Samples were analyzed in the form of 6 brands of facial moisturizer cream that sold in market and selected randomly. The cream samples were destructed by wet destruction method. Next, the samples of destruction result were analyzed by atomic absorbtion spectrophotometry method with wavelength about 228.8 nm to determine the concentration of cadmium. The results of this research showed that there was cadmium (Cd) metal content in the 2 samples of facial moisturizing cream that analyzed. Cadmium metal concentration on brand A is 0.1389 ± 2.7817 x 10-3 ppm and and brand B is 0.1321 ± 2.6468 x 10-3 ppm. Based on this result, the moustirizing creams are safe to use due to the BPOM regulation
Utilization of Natural Coagulant Substance (Tamarind and Winged Bean Seed) on the Quality of Tofu Wastewater in Muntilan, Magelang
Authors: Elpani S. E. , Gunawan M. J. , Aviventi E. , Sabila R. A. 
Published: March 2022

The aim of this study is to determine the effect of various mass in tamarind and winged bean seeds on pH, TDS, and COD in tofu factory wastewater. The research was conducted at the Chemistry Research Laboratory of FMIPA UNY in December 2018. The results showed that the addition of various mass in tamarind and winged bean seeds as much as 7, 9, and 11 grams of tofu factory wastewater had an effect on pH which increased from the initial condition of 2.5 to 2.6; 2.7; 2.8 in tamarind seeds, and 2.8; 2.9; 3.0 on winged beans. The COD test increased from the initial condition of 6619.20 mg / L to 7312, 64; 7880, 00; 8195.20 mg / L in tamarind seeds, and 9140.80; 10464.64; 9329.92 mg / L in winged bean seeds which have decreased again in the addition of 11-gram coagulant substance mass. TDS test has increased from the initial conditions of 1512 mg / L to 1715; 1736; 1848 mg / L in tamarind seeds, and 1890; 1988; 1855 mg / L in winged bean seeds.
PEDOMAN DESAIN TATA LETAK UNTUK BENGKEL PRAKTIK KERJA KAYU SMK
Authors: Saputro Rizki Adi , Hidayah Retna 
Published: March 2022

Penelitian ini bertujuan untuk mengembangkan media buku pedoman tata letak pada bengkel praktik kerja kayu SMK. Metode penelitian ini menggunakan penelitian pengembangan Research and Development (RD). Model pengembangan yang digunakan dalam penelitian menggunakan 4D (Four D) dikemukakan oleh Thiagarajan. Model ini terdapat empat tahapan yaitu: yaitu: pendefinisian (define), perancangan (design), pengembangan (develop), dan penyebaran (disseminate). Instrumen penelitian yang digunakan berupa angket untuk mengetahui kelayakan media pembelajaran. Hasil penelitian pengembangan buku pedoman ini berupa prosedur pembuatan buku pedoman melalui tahap: pendefinisian (peneliti menganalisa kebutuhan buku pedoman), perancangan (peneliti mengumpulkan referensi materi dan menyusun buku pedoman), pengembangan (penilaian kelayakan buku pedoman berdasarkan analisis ahli materi memperoleh skor 4,63 dengan kategori sangat layak, ahli media memperoleh skor 4,77 dengan kategori sangat layak, serta hasil uji kelayakan oleh pengguna memperoleh skor 4,73 dengan kategori sangat layak), dan penyebarluasan (peneliti menyebarkan buku pedoman dengan memberikan kepada pihak SMK N 2 Pengasih satu buku cetak dan bentuk soft file agar dapat diperbanyak secara mandiri).
Penggunaan Shelter yang Berbeda terhadap Performa Udang Windu (Penaeus monodon) dengan Sistem Zero Water Discharge
Authors: Nuralim Nuralim , Rahim Rahim , Asni Asni 
Published: March 2022

Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan shelter terhadap pertumbuhan dan kelangsungan hidup post Larva udang windu (Penaeus monodon) dengan sistem zero water discharge. Waktu pelaksanaan pada bulan Agustus-Oktober 2020. Rancangan percobaan yang dilakukan adalah Rancangan Acak Lengkap (RAL) dengan 3 perlakuan dan 3 kali pengulangan. Adapun perlakuan tersebut yaitu A= shelter ranting bakau, B= shelter pelepah pepaya, C= shelter ijuk. parameter yang diamati pada penelitian ini adalah kelangsungan hidup, pertumbuhan bobot mutlak, laju pertumbuhan spesifik, rasio konversi pakan dan kualitas air. Hasil penelitian menunjukkan bahwa penggunaan shelter tidak berpengaruh nyata terhadap pertumbuhan dan dan kelangsungan hidup post larva udang windu yang dipelihara dengan sistem zero water discharge
Uji Efektivitas Arang Aktif Daun Pandan Laut yang Diaktivasi dengan Natrium Hidroksida untuk Adsorpsi Ion Fe3+ secara Sistem Kolom
Authors: Sulistyani Sulistyani , Dwi Siswani Endang , Kristianingrum Susila , Fillaeli Annisa , Saputri Isnaini 
Published: March 2022

Penelitian ini memaparkan daun pandan laut sebagai alternatif baru bahan untuk membuat arang aktif, serta identifikasi kemampuan adsorpsinya secara sistem kolom. Daun pandan laut mengalami proses pemanasan hingga menjadi arang, dilanjutkan dengan proses aktivasi kimia dengan menggunakan larutan natrium hidroksida 1% dan aktivasi fisika dengan dialiri gas karbon dioksida. Arang aktif hasil sintesis dianalisis kondisi optimum adsorpsinya secara sistem kolom, yang meliputi massa arang aktif dan laju alir. Selanjutnya pada kondisi optimumnya, diuji daya adsorpsi arang aktif terhadap ion Fe3+. Konsentrasi ion Fe3+ sebelum dan sesudah adsorpsi dideteksi dengan menggunakan spektrofotometer UV-vis, dengan menambahkan reagen tiosinat. Hasil penelitian ini menunjukkan bahwa semakin banyak massa adsorben yang digunakan, efisiensi adsorpsi semakin baik. Pada rentang massa 0,3-0,7 gram, efisiensi adsorpsi tertinggi arang aktif terjadi pada massa 0,7 gram, dengan nilai efisiensi adsorpsi ion Fe3+ sebesar 96,92%. Pada analisis laju alir diperoleh bahwa laju alir lambat menghasilkan daya adsorpsi yang lebih baik dibandingkan laju alir cepat. Laju alir terbaik larutan ion Fe3+ terjadi pada 0,2 mL/menit dengan nilai efisiensi sebesar 99,39%. Berdasarkan kondisi optimum tersebut dapat ditentukan daya adsorpsi adsorben terhadap ion Fe3+ sebesar 30,58 mg/g.
PENGARUH LATIHAN SENAM KESEGARAN JASMANI (SKJ) 2017 TERHADAP PENINGKATAN KESEIMBANGAN DAN DAYA TAHAN KARDIORESPIRASI
Authors: Suharti Suharti , Kriswanto Erwin Setyo 
Published: March 2022

AbstrakPenelitian ini bertujuan untuk menguji pengaruh latihan Senam Kesegaran Jasmani (SKJ) 2017 terhadap keseimbangan dan daya tahan kardiorespirasi. Penelitian ini menggunakan jenis penelitian kuantitatif dengan metode eksperimen semu (Quasi experimental), dengan ­pre test-post test desain. Populasi penelitian adalah mahasiswa Pendidikan Kepelatihan Olahraga angkatan 2016 Universitas PGRI Adi Buana. Penentuan sampel dengan purposive random sampling, sehingga sampel yang ditentukan berjumlah 33 mahasiswa. Instrumen penelitian untuk mengetahui keseimbangan menggunakan balance beam test sedangkan daya tahan kardiorespirasi menggunakan multy stage fitness test. Analisis data menggunakan uji t. Simpulan penelitian ini adalah ada pengaruh yang signifikan latihan Senam Kesegaran Jasmani (SKJ) 2017 terhadap peningkatan keseimbangan dan daya tahan kardiorespirasi. THE EFFECT OF "SENAM KESEGARAN JASMANI 2017" TRAINING ON THE IMPROVEMENT OF BALANCE AND CARDIORESPIRATORY FITNESS AbstractsThis study aims to examine the effect of “Senam Kesegaran Jasmani (SKJ) 2017” exercises on cardiorespiratory balance and endurance. This study uses quantitative research with quasi-experimental methods (Quasi-experimental), with pre-test-post test design. The study population was students of 2016 Sports Training Education at the University of PGRI Adi Buana University. Determination of the sample by purposive random sampling, so that the determined sample numbered 33 students. Research instruments to determine the balance using a balance beam test while cardiorespiratory endurance uses a multi-stage fitness test. Data analysis using t-test. This study concludes that there is a significant influence on the “Senam Kesegaran Jasmani (SKJ) 2017” on increasing the balance and endurance of cardiorespiratory.
Penerapan aktivitas fisik outbound dan brain gym dalam menumbuhkan kinerja instruktur wisata air titik 0 Jawa Tengah
Authors: Prasetyo Yudik , Sutapa Panggung , Prihantanta Hadwi , Arjuna Fatkurahman 
Published: March 2022

Peran instruktur dalam memberikan pelayanan kepada pengunjung menjadi ujung tombak keberhasilan tempat wisata. Wisata Air Titik 0 Jawa Tengah adalah destinasi wisata air yang lebih erat dengan menu aktivitas olahraga. Kepuasan pengunjung merupakan tujuan, terutama dari penyedia jasa Wisata Air Titik 0 Jawa Tengah. Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Sampel yang digunakan dalam penelitian ini berjumlah 30 orang. Hasil penelitian ini menunjukkan bahwa (1) kinerja instruktur Wisata Air Titik 0 Jawa Tengah cukup baik, (2) penerapan outbound dilakukan secara baik dengan tahapan: perencanaan, pelaksanaan dan evaluasi, (3) instruktur semakin baik dalam hal kerjasama, kedisiplinan, dan tanggung jawab. Implementation of outbound and brain gym physical activities in growing performance of instructors point 0 Central Java AbstractsThe role of instructors in providing services to visitors is the spearhead of the success of tourist attractions. Water Tourism Point 0, Central Java is a water tourism destination that is closer to a menu of sports activities. Visitor satisfaction is a goal, especially from Water Tourism service provider Point 0 Central Java. Therefore the purpose of this study is the application of physical activity outbound and brain gym in fostering the performance of the Water Tour Instructor Point 0, Central Java. The method used in this research is descriptive method with a qualitative approach. Data collection techniques using observation, interviews, and documentation. The sample used in this study amounted to 30 people. The results of this study indicate that (1) the performance of the Water Tourism Instructor Titik 0 Central Java is quite good, (2) implementation of the outbound is done well in stages: planning, implementation, and evaluation, (3) the instructor is getting better in terms of cooperation, discipline, and responsibility.
Hambatan dalam pembelajaran senam di Sekolah Dasar
Authors: Meikahani Ranintya , Sukoco Pamuji , Mulyaningsih Farida , Iswanto Ari 
Published: March 2022

Senam merupakan salah satu cabang olahraga yang gerakannya sangat komplek dan memiliki manfaat untuk mengembangkan komponen fisik serta kemampuan gerak, khususnya pada anak usia sekolah dasar. Pembelajaran senam dalam setiap jenjang pendidikan memiliki tingkat kesulitan yang berbeda-beda. Penelitian ini bertujuan untuk mengetahui hambatan apa saja yang menjadi permasalahan dalam pembelajaran senam di sekolah dasar. Metode penelitian yang digunakan adalah deskriptif kuantitatif menggunakan metode survey dengan teknik pengambilan data menggunakan angket. Populasi penelitian adalah Guru Penjasorkes se-Daerah Istimewa Yogyakarta. Teknik analisis data menggunakan analisis deskriptif yang dituangkan dalam persentase. Hasil dari penelitian ini menunjukkan bahwa hambatan dalam pembelajaran senam berdasarkan lima aspek, yaitu aspek guru sebesar 16,86%, murid sebesar 42,15%, sarana dan prasarana sebesar 30,39%, kurikulum sebesar 6,53% dan lingkungan sebesar 17,64%. BARRIERS IN GYMNASTICS LEARNINGAbstractsGymnastics is a sport whose movements are very complex and have benefits for developing physical components and mobility, especially for elementary school-aged children. Gymnastics learning at every level of education has different levels of difficulty. This study aims to determine what barriers are the problems in learning gymnastics in elementary schools. The research method used is descriptive quantitative using survey methods with data collection techniques using a questionnaire. The study population was Physical Education Teachers in the Special Region of Yogyakarta. The data analysis technique used descriptive analysis as stated in the percentage. The results of this study indicate that the barriers in gymnastics learning are based on five aspects, namely the teacher aspect of 16.86%, the student's 42.15%, the facilities and infrastructure of 30.39%, the curriculum of 6.53% and the environment of 17. 64%.
PERAN GERWANI DALAM TRI KOMANDO RAKYAT (TRIKORA) 1961-1963
Authors: Kurnia Dimas Dwi , Miftahuddin Miftahuddin 
Published: March 2022

Kemunculan Trikora berkaitan erat dengan permasalahan Irian Barat. Sebagai jawaban atas tidak kunjung selesainya masalah Irian Barat, pada tahun 1961 Soekarno mengumumkan Tri Komando Rakyat (Trikora) di Yogyakarta. Sementara itu, sejak awal tahun 1962, politik Gerwani banyak diarahkan ke masalah Irian Barat. Gerwani mengajak kaum wanita muda untuk berpartisipasi dalam kampanye nasional pembebasan Irian Barat. Gerwani kemudian terlibat dalam aksi-aksi demonstrasi menentang kolonialisme Belanda di Irian Barat. Berdasarkan rapat kerja aktivitas Gerwani yang diadakan pada September 1962, para anggota Gerwani diminta mendaftarkan diri sebagai sukarelawati untuk pembebasan Irian Barat dengan mengirimkan bantuan ke garis depan dan membantu keluarga sukarelawati di garis belakang. Kata Kunci: Gerwani, Trikora, dan 1961-1963
JOSEPHUS VAN LITH DALAM PERKEMBANGAN PENDIDIKAN KARAKTER DI JAWA AWAL ABAD 20
Authors: Widiyanta Danar 
Published: March 2022

Josephus Van Lith adalah tokoh dalam Pendidikan yang sezaman dengan Ki Hajar Dewantara, dan Ki Haji Ahmad Dahlan. Josephus Van Lith mengembangkan Pendidikan progresif berdasarkan pada Rohani kekristenan dan Budaya Jawa. Josephus Van Lith melakukan penyelarasan harmonis antara agama dan pengetahuan umum, dengan harapan manusia mencapai keseimbangan dalam kebutuhan material dan spiritual. Dalam mengembangkan pendidikannya Josephus Van Lith juga mengembangkan pendidikan karakter dengan basis kearifan lokal. Meskipun bukan orang Jawa, tetapi Josephus Van Lith menguasai dan mengembangkan Budaya Jawa. Kearifan lokal Budaya Jawa diterapkan dalam pendidikan karakter yang dikembangkan dalam Pendidikan masyarakat pribumi di Muntilan khususnya dan Jawa pada umumnya pada awal abad ke-20.Kata Kunci: Josephus Van Lith, Pendidikan Karakter, jawa.
Liver proliferating cell nuclear antigen, BAX/Bcl-2 ratio, collagen, and polysaccharide accumulation as diagnostic tools in experimental hepatocellular carcinoma
Authors: Abdel-Hamid Nabil Mohie , Hassan Mohamed K , Ahmed Amal AM , Abd Allah Sara Gamal , Anber Nahla H. 
Published: March 2022

Objectives: This experimental study was conducted to look for a sensitive diagnostic panel for early detection of HCC.
Methods: Combination of diethyl nitrosamine (DENA, 200 mg/kg, IP, once), two weeks later, CCl4(3ml/kg/week), subcutaneously, for 6 weeks) induced HCC in rats. Sixteen male Wistar rats were divided into 2 groups, control, and HCC.
Results: DENA plus CCl4 elevated serum alpha-fetoprotein, liver enzyme activity and depressed superoxide dismutase, reduced glutathione (GSH), elevated malondialdehyde. Also, depressed caspase-3, elevated collagen, polysaccharide accumulation, proliferating cell nuclear antigen in liver tissues, and depressed BAX / Bcl-2 ratio.
Conclusion: Decreased BAX/Bcl-2 ratio, elevated collagen deposition, polysaccharide accumulation, nuclear proliferation, and tissue oxidative stress help in the early diagnosis of liver cancer.
Role of Mitochondrial DNA in Development of Type 2 Diabetes Mellitus with/without Ischemic Heart Diseases of Iraqi Patients
Authors: Abed Ali Musa , Al-Shuk Muneim Maki , Ahmed Saja Talib , Al-Tu'ma Fadhil Jawad 
Published: March 2022

Objectives: This study aimed to investigate the associations between various biomarkers and the specific mutation of mitochondrial DNA in type 2 diabetes mellitus with ischemic heart diseases and compared with T2DM patients without ischemic heart disease.
Methods: The study select two groups of patients admitted to Kerbala Heart Center and Al-Hassan Center for Endocrinology and Diabetes, Al-Hussein Teaching Hospital, Al-Hussein Medical City, Kerbala Health Directorates / Kerbala – Iraq between Nov., 2020 and Aug., 2021. The first group includes 50 patients of type 2 diabetes mellitus with ischemic heart disease (28 male and 22 female) with age ranged between 45-76 years, and the second group includes another 50 patients with type 2 diabetes mellitus without ischemic heart disease (24 male and 26 female) with age ranged between 49-82 years. Fasting serum glucose, insulin and insulin resistance have been determined and then correlated with nutation mitDNA investigated in sera of T2DM with/without ischemic heart diseases.
Results: The amplification of the MTLL1 gene gives one genotypes as indicated by (422 bp) bands for those with homozygous wild type (AA), homozygous mutant (GG) genotypes and two genotypes bands (422 bp) for those with heterozygous (GA). The obtained data revealed that a strong positive correlation between Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and insulin (r = 0.926) with significant differences (P<0.05) was obtained in the sera of type 2 diabetic patient with ischemic heart disease as compared with that obtained in type 2 diabetic patients without ischemic heart diseases.
Conclusion: The prevalence of association between HOMA-IR with MTTL1 G3243A mutation (GG allele) in type 2 diabetic patients with ischemic heart disease was only 8.0% and may be associated with maternally inherited of type 2 diabetes mellitus with ischemic heart disease as a pathogenic mutation in Iraqi population.
Lafaz Al Bai’u Mistlu Al Riba dalam Surah Al Baqarah Ayat 275
Authors: Zainuddin Zainuddin , Zainuddin Anayya Syadza 
Published: March 2022

This paper discusses the views of the commentators on the lafadz al-bai'u mitslu al-riba in surah al-Baqarah verse 275. Some commentators interpret the word amtsal, as tasybih and majaz, and others interpret it as i'jaz. This paper uses the method of interpretation of tahlili, through the approach of the field of amtsal al-Qur'an, literature research. The main sources are the books of tafsir, with the aim of studying and knowing the lafadz al-bai'u mitslu al-riba according to the mufassirs. So that the economic principles of monotheism, humanity, justice and peace were developed. The conclusion of this article is that Allah deliberately raised the parable of the ignorant, because socio-cultural Arab society and humans in general have a culture that is difficult to abandon the practice of usury until now, even building the image of tasybih maqlūb style that usury and buying and selling are the same in terms of taking more profit.ABSTRAKTulisan ini membicarakan pandangan para mufassir tentang lafadz al-bai’u mitslu al-riba dalam surah al-Baqarah ayat 275. Sebahagian mufassir menafsirkan lafaz amtsal, sebagai tasybih dan majaz, dan lainya memaknai dengan i’jaz. Tulisan ini menggunakan metode penafsiran tahlili, melalui pendekatan bidang amtsal al-Qur’an, penelitian kepustakaan. Sumber utama adalah kitab-kitab tafsir, dengan tujuan untuk mengkaji dan mengetahui lafadz al-bai’u mitslu al-riba menurut para mufassir. Sehingga terbangun prinsip ekonomi ketauhidan, kemanusiaan, keadilan dan kedamaian. Kesimpulan tulisan ini sengaja Allah mengangkat kembali perumpamaan kaum jahiliyah, Sebab secara sosio kultural masyarakat Arab dan manusia pada umumnya memiliki budaya yang sulit meninggalkan praktik riba hingga sekarang, bahkan membangun image gaya tasybih maqlūb bahwa riba dan jual beli itu sama dari segi mengambil nilai lebih keuntungan.