bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of disease on a two-patch eco-epidemic model in presence of prey dispersal
Authors: Saha Sangeeta , Samanta Guruprasad 
Published: October 2022

AbstractThe present model is dealt with prey-predator interactions in two different patches where only prey species are allowed to disperse among the patches. Each of these two patches has different predator population but the predator in Patch-2 only is affected with a disease. The proposed model is biologically welldefined. Also, the feasibility of the equilibrium points and corresponding stability conditions are analysed. It is found that the disease among predator, even in one patch, makes an important role to control the whole system dynamics as it starts to oscillates by regulating the disease transmission rate. Moreover, the disease transmission rate has a stabilizing as well as destabilizing effect on the system dynamics. From the results, it is observed that a high dispersal rate decreases the count of infected predator in a patch in presence of prey dispersal. There is another interesting result: it is observed that the prey dispersal cannot destabilize the coexistence state, i.e., the system which is stable in absence of dispersal remains stable when the prey species disperse between two patches.
Regulation of Lysosomal Associated Membrane Protein 3 (LAMP3) in Lung Epithelial Cells by Coronaviruses (SARS-CoV-1/2) and Type I Interferon Signaling
Authors: Ramana Chilakamarti V. , Das Bikul 
Published: October 2022

Abstract
Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) infection is a major risk factor for mortality and morbidity in critical care hospitals around the world. Lung epithelial type II cells play a major role in the recognition and clearance of respiratory viruses as well as repair of lung injury in response to environmental toxicants. Gene expression profiling studies revealed that mouse lung epithelial type II cells express several cell-specific markers including surfactant proteins and Lysosomal associated membrane protein 3 (LAMP3) located in lysosomes, endosomes and lamellar bodies. These intracellular organelles are involved in vesicular transport and facilitate viral entry and release of the viral genome into the host cell cytoplasm. In this study, regulation of LAMP3 expression in human lung epithelial cells by several respiratory viruses and type I interferon signaling was investigated. Respiratory viruses including SARS-CoV-1 and SARS-CoV-2 significantly induced LAMP3 expression in lung epithelial cells within 24 hours after infection that required the presence of ACE2 viral entry receptors. Time course experiments revealed that the induced expression of LAMP3 was correlated with the induced expression of Interferon–beta (IFNB1) and STAT1 at mRNA levels. LAMP3 was also induced by direct IFN-beta treatment in multiple lung epithelial cell lines or by infection with influenza virus lacking the non-structural protein1(NS1) in NHBE bronchial epithelial cells. LAMP3 expression was also induced by several respiratory viruses in human lung epithelial cells including RSV and HPIV3. Location in lysosomes and endosomes aswell as induction by respiratory viruses and type I Interferon suggests that LAMP3 may have an important role in inter-organellar regulation of innate immunity and a potential target for therapeutic modulation in health and disease. Furthermore, bioinformatics revealed that a subset of lung type II genes were differentially regulated in the lungs of COVID-19 patients.
On the existence of global weak solutions of a 2D sediment transport model
Authors: Zongo Yacouba , Roamba Brahima , Yira Boulaye , De Dieu Zabsonré Jean 
Published: October 2022

Abstract
In the abstract, homogenize the references as follows: In this paper,we study the existence of global weak solutions of a two dimensionnal model. The model is inspired by the one studied in [Math. Models Methods Appl. Sci. 19 (2009), 477-499]. Our model is a particular case of the two-dimensionnal sediment transport model derived in [Mathematical Modelling and Numerical Analysis 51 (2017), 115-145]. The main contribution of this article is to extend the results obtained 10 in [C. R. Math. Acad. Sci. Paris, 344 (2007), 443-446; Math. Models Methods Appl. Sci. 19 (2009), 477-499] by showing the existence of global weak solution of a sediment transport model without assuming the data to be small enough, following the ideas proposed in [Inv. Math.206 (2016), 935-974].
Mean girls, queen bees and iron maidens? Female leadership and accusations of workplace bullying
Authors: Stolz Celina , Reinhard Marc-André , Ende Luise 
Published: October 2022

Abstract
We examined whether female leaders would be evaluated less favorably compared to male leaders regarding workplace bullying. Previous research has demonstrated that women violating prescriptive gender norms of communality experience backlash, and that female leaders are stereotyped of having a communality deficit. Building on that, we hypothesized (1) more moral outrage against and (2) more intentions to punish a female leader compared to a male leader. We further hypothesized (3) the accusations of workplace bullying against a female leader were going to be judged as more accurate than against a male leader. Further, defendants that stereotypically fit to the crime they are accused of were found to be judged guilty more often. So, we assumed, (4) a suspected bully that is a female leader was going to be judged as less credible, while (2) the suspected victim of a female leader bully was going to be judged as more credible compared to a male leader. Participants (N = 202) read a workplace bullying scenario with a female employee accusing either a female or a male leader of bullying. No effect of gender of suspected bully was found for moral outrage measures, punishment intention judgments, and credibility judgments. Contrary to our predictions, participants found the accusations against the male leader significantly more accurate than against the female leader. Gender and sex-role scores of participants were found to be linked to judgments. Implications for future research are discussed.
Exponential type orbitals with hyperbolic cosine function basis sets for isoelectronic series of the atoms Be to Ne
Authors: Sahin Ercan , Ertürk Murat , Ozdogan Telhat , Orbay Metin 
Published: October 2022

Abstract
Exponential type orbital with hyperbolic cosine basis functions, proposed recently for Hartree–Fock–Roothaan calculations of neutral atoms, are studied in detail for the calculations of isoelectronic series of atoms from Be to Ne. Calculations are performed for the neutral and the first 20 cationic members of the isoelectronic series of each atom in its ground state. Three of the most popular exponential type orbitals (Slater type functions, B functions and ψ
(α) functions with α = 2) are combined with modified hyperbolic cosine function cosh(βr + γ) to improve the basis function quality within the minimal basis sets framework. Performances of the basis functions are compared with each other by using the same number of variational parameters in them. The obtained results are also compared with numerical Hartree–Fock and extended Slater type basis set results. The presented accuracy of the minimal basis descriptions of atomic systems supports the usage of these unconventional basis functions in electronic structure and property calculations.
Investigation of Wear and Wire Electrical Discharge Machining Characteristics of Al-Mg-MoS2 Composites Using Response Surface Method
Authors: Senthil Kumar S. , Sudhakara Pandian R. , Pitchipoo P. , Senthilkumar T. S. , Ponnambalam S. G. 
Published: October 2022

Abstract
Aluminum metal matrix composites remain sophisticated materials with a broad series of applications because of their high strength-to-weight ratio, better resistance to wear and corrosion, improved high-temperature zone applications, and reasonable machinability. Furthermore, when manufactured through the powder metallurgy process, the tribological and machinability properties of aluminum-magnesium–based composites are found to be improved with the inclusion of molybdenum disulfide reinforcement. The response surface methodology technique was used for estimating the wear loss and coefficient of friction to study the tribological property. Also, it is employed in the wire electrical discharge machining (WEDM) technique, to predict material removal rate, surface roughness, and overcut. The projected values in both the wear and WEDM parameters are well within the minimal error value, according to the perturbation plot, and sufficient validation has been performed. The created model reveals that at 15 N, 2 m/s, 750 m, and 15 A, 90 µs, and 45 V, better tribology and WEDM characteristics are acquired.
Prognostic Value of Tumor-microenvironment-associated Genes in Ovarian Cancer
Authors: Li Shimei , Yao Jiyi , Zhang Shen , Zhou Xinchuan , Zhao Xinbao , Di Na , Hao Shaoyun , Zhi Hui 
Published: October 2022

Abstract

Background: Ovarian cancer (OV) is the fifth leading cause of cancer death among women. Growing evidence supports a key role of the tumor microenvironment in the growth, progression, and metastasis of OV. However, the prognostic effects of gene expression signatures associated with the OV microenvironment have not been well established. This study was aimed at applying the Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data (ESTIMATE) algorithm to identify tumor-microenvironment-associated genes that predict outcomes in patients with OV.

Methods: The gene expression profiles of OV samples were downloaded from The Cancer Genome Atlas database. The immune and stromal scores of 469 OV samples on the basis of the ESTIMATE algorithm were available. To better understand the effects of gene expression signatures associated with the OV microenvironment on prognosis, we categorized these samples into groups with high and low ESTIMATE scores. A different OV cohort from the Gene Expression Omnibus (GEO) database and immunohistochemistry from The Human Protein Atlas database were used for external validation.

Results: The molecular subtypes of patients with OV correlated with the stromal scores, and the mesenchymal subtype had the highest stromal scores. Patients with higher stromal scores had lower 5-year overall survival; 449 differentially expressed genes in the stromal score group were identified, 26 of which were significantly associated with poor prognosis in patients with OV (p < 0.05). In another OV cohort from the Gene Expression Omnibus database, six genes were further validated to be significantly associated with poor prognosis. Immunohistochemistry data from The Human Protein Atlas database confirmed the overexpression of CX3CR1, GFPT2, NBL1, TFPI2, and ZFP36 in OV tissues compared with normal tissues.

Conclusion: Our findings suggest that CX3CR1, GFPT2, NBL1, TFPI2, and ZFP36 may be promising biomarkers for OV prognosis, with clinical implications for therapeutic strategies.
Blood–Brain Barrier Disruption in Preclinical Mouse Models of Stroke Can Be an Experimental Artifact Caused by Craniectomy
Authors: Liu Che-Wei , Wang Eric Yuhsiang , Wang Hwai-Lee , Liao Kate Hsiurong , Chen Hsiao-Yun , Chen Hank Szuhan , Lai Ted Weita 
Published: October 2022

AbstractThe pathophysiological features of ischemia-related blood–brain barrier (BBB) disruption are widely studied using preclinical stroke models. However, in many of these models, craniectomy is required to confirm arterial occlusion via laser Doppler flowmetry or to enable direct ligation of the cerebral artery. In the present study, mice were used to construct a distal middle cerebral artery occlusion (dMCAO) model, a preclinical stroke model that requires craniectomy to enable direct ligation of the cerebral artery, or were subjected to craniectomy alone. dMCAO but not craniectomy caused neurodegeneration and cerebral infarction, but both procedures induced an appreciable increase in BBB permeability to Evans blue dye, fluorescein, and endogenous albumin but not to 10 kDa dextran-FITC, leading to cerebral edema. Using rats, we further showed that BBB disruption induced by craniectomy with no evidence of dural tearing was comparable to that induced by craniectomy involving tearing of the dura. In conclusion, our data demonstrated that craniectomy can be a major contributor to BBB disruption and cerebral edema in preclinical stroke models. The implications of this experimental artifact for translational stroke research and preclinical data interpretation are discussed.
Sensory Target Detection at Local and Global Timescales Reveals a Hierarchy of Supramodal Dynamics in the Human Cortex
Authors: Niedernhuber Maria , Raimondo Federico , Sitt Jacobo D. , Bekinschtein Tristan A. 
Published: October 2022

To ensure survival in a dynamic environment, the human neocortex monitors input streams from different sensory organs for important sensory events. Which principles govern whether different senses share common or modality-specific brain networks for sensory target detection? We examined whether complex targets evoke sustained supramodal activity while simple targets rely on modality-specific networks with short-lived supramodal contributions. In a series of hierarchical multisensory target detection studies (n= 77, of either sex) using EEG, we applied a temporal cross-decoding approach to dissociate supramodal and modality-specific cortical dynamics elicited by rule-based global and feature-based local sensory deviations within and between the visual, somatosensory, and auditory modality. Our data show that each sense implements a cortical hierarchy orchestrating supramodal target detection responses, which operate at local and global timescales in successive processing stages. Across different sensory modalities, simple feature-based sensory deviations presented in temporal vicinity to a monotonous input stream triggered a mismatch negativity-like local signal which decayed quickly and early, whereas complex rule-based targets tracked across time evoked a P3b-like global neural response which generalized across a late time window. Converging results from temporal cross-modality decoding analyses across different datasets, we reveal that global neural responses are sustained in a supramodal higher-order network, whereas local neural responses canonically thought to rely on modality-specific regions evolve into short-lived supramodal activity. Together, our findings demonstrate that cortical organization largely follows a gradient in which short-lived modality-specific as well as supramodal processes dominate local responses, whereas higher-order processes encode temporally extended abstract supramodal information fed forward from modality-specific cortices.SIGNIFICANCE STATEMENTEach sense supports a cortical hierarchy of processes tracking deviant sensory events at multiple timescales. Conflicting evidence produced a lively debate around which of these processes are supramodal. Here, we manipulated the temporal complexity of auditory, tactile, and visual targets to determine whether cortical local and global ERP responses to sensory targets share cortical dynamics between the senses. Using temporal cross-decoding, we found that temporally complex targets elicit a supramodal sustained response. Conversely, local responses to temporally confined targets typically considered modality-specific rely on early short-lived supramodal activation. Our finding provides evidence for a supramodal gradient supporting sensory target detection in the cortex, with implications for multiple fields in which these responses are studied (e.g., predictive coding, consciousness, and attention).
Chromatin remodeling is required for sRNA‐guided DNA elimination in Paramecium
Authors: Singh Aditi , Maurer‐Alcalá Xyrus X , Solberg Therese , Häußermann Lilia , Gisler Silvan , Ignarski Michael , Swart Estienne C , Nowacki Mariusz 
Published: October 2022

AbstractSmall RNAs mediate the silencing of transposable elements and other genomic loci, increasing nucleosome density and preventing undesirable gene expression. The unicellular ciliate Paramecium is a model to study dynamic genome organization in eukaryotic cells, given its unique feature of nuclear dimorphism. Here, the formation of the somatic macronucleus during sexual reproduction requires eliminating thousands of transposon remnants (IESs) and transposable elements scattered throughout the germline micronuclear genome. The elimination process is guided by Piwi‐associated small RNAs and leads to precise cleavage at IES boundaries. Here we show that IES recognition and precise excision are facilitated by recruiting ISWI1, a Paramecium homolog of the chromatin remodeler ISWI. ISWI1 knockdown substantially inhibits DNA elimination, quantitatively similar to development‐specific sRNA gene knockdowns but with much greater aberrant IES excision at alternative boundaries. We also identify key development‐specific sRNA biogenesis and transport proteins, Ptiwi01 and Ptiwi09, as ISWI1 cofactors in our co‐immunoprecipitation studies. Nucleosome profiling indicates that increased nucleosome density correlates with the requirement for ISWI1 and other proteins necessary for IES excision. We propose that chromatin remodeling together with small RNAs is essential for efficient and precise DNA elimination in Paramecium.
¿Aprender, Compartir, Contribuir? Perspectivas de Personas con Discapacidad Intelectual sobre su Participación en Investigaciones
Authors: Diaz-Garolera Gemma , Fullana Judit , Pallisera Maria , Puyaltó Carolina , Rey Ana 
Published: October 2022

La Convención de los Derechos de las Personas con Discapacidad reconoce el valor de las contribuciones que éstas pueden realizar al bienestar y a la diversidad y, con ello, el papel activo que deben desarrollar en las investigaciones que tratan sobre sus vidas. El año 2012 el Grupo de Investigación en Diversidad de la Universitat de Girona constituyó un Consejo Asesor formado por personas con discapacidad intelectual. Desde este momento hasta la actualidad han integrado este Consejo 35 personas, participando en actividades de asesoramiento, colaboración y gestión de investigaciones sobre la discapacidad. El artículo muestra qué ha representado para estas personas participar en procesos de investigación. Se han analizado más de 380 documentos producidos durante nueve años (actas y transcripciones de reuniones, vídeos, presentaciones, etc.). Los participantes valoran positivamente compartir experiencias, aprender, socializarse, trabajar temas relevantes para sus vidas en un contexto de respeto hacia sus aportaciones. Valoran, aunque con menor énfasis, su contribución al conocimiento sobre la discapacidad. Del estudio se desprende la necesidad de implicar a los asesores en acciones de movilización del conocimiento dirigidas al ámbito profesional y las políticas sociales para poner en valor el papel necesario que ellos tienen para el cambio social.
ShakeMap4-Web: Web Application for ShakeMap 4 Product Visualization
Authors: Jozinović Dario , Lauciani Valentino , Bruni Sergio , Faenza Licia , Michelini Alberto 
Published: October 2022

Abstract
We present a web portal for prompt visualization of the maps of ground shaking generated using U.S. Geological Survey ShakeMap version 4 software. The web interface renders the standard products provided by ShakeMap dynamically (using Leaflet) and statically (standard ShakeMaps). The information included in the dynamic maps can be configured through different overlays. The dual-view rendering modality allows presenting side-by-side maps of different intensity measurements. In addition, for each earthquake, it is possible to download all the data that contributed to the calculation, together with information on the seismological models adopted. The appearance of the web portal is easily configurable by replacing the logo and banners. The software can be installed both on laptops and on server computers. The user can opt between the Docker image or installation of the software after installation of a web server (e.g., NGINX or Apache).
COMPARISON AS A COGNITIVE BASIS FOR CONFLICT-FREE LANGUAGE COMMUNICATION
Authors: Блохина Е.Д. 
Published: October 2022

Рассматриваются определения языкового общения, вторичной интерпретации, сравнения. Выделяются когнитивные основы и принципы бесконфликтного языкового общения. Изучается прямая зависимость эффективности языкового общения от выбора языковых средств на примере такого когнитивного и языкового механизма, как сравнение. На примере сравнений в русском и французском языках выделяются типы оценочных категорий, создающие когнитивную основу для бесконфликтного и конфликтного языкового общения, – нейтральная, положительная, отрицательная. Устанавливается прямое влияние сравнения на важнейшие категории коммуникации – эффективное/неэффективное общение, успешный/неуспешный дискурс, коммуникативная норма.
The article deals with the definitions of language communication, secondary interpretation, comparison. The cognitive foundations and principles of conflict-free language communication are highlighted. The direct dependence of the effectiveness of linguistic communication on the choice of linguistic means is studied on the example of such a cognitive and linguistic mechanism as comparison. on the example of comparisons in Russian and French, types of evaluative categories are distinguished that create a cognitive basis for confl ict-free and confl ictual language communication - neutral, positive, negative. The direct infl uence of comparison on the most important categories of communication is established – effective/ineff ective communication, successful/unsuccessful discourse, communicative norm.
TYPOLOGY OF ERRORS IN TEACHING RFL TO INOFON STUDENTS
Authors: Калинина Г.С. 
Published: October 2022

Рассматриваются процесс обучения русскому языку как иностранному и особенности его усвоения учащимися с генеалогически разными родными языками. Представлена типология ошибок, регулярно возникающих при обучении русскому языку как иностранному иностранных студентов с родным арабским языком на начальном этапе. Выявлено, что знание типологии последовательных и регулярных отступлений, а также использование системы специальных упражнений помогут избежать такого негативного явления, как смешение.
This study is part of a large work on the study of the process of teaching Russian as a foreign language and the peculiarities of its assimilation by students with genealogically different native languages. We proceed from the fact that at the initial stage, all students make universal (general, independent of their native language) and specific mistakes, which are markers. This article is devoted to the study of the typology of errors that regularly occur when teaching Russian as a foreign language to foreign students with their native Arabic at the initial stage. Typology knowledge of successive and regular retreats, as well as the use of a system of special exercises, will help to avoid such a negative phenomenon as confusion.