bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repercussão da Doença de Alzheimer na qualidade de vida dos idosos e seus familiares
Authors: Madeira Bicalho Elmer , Serpa de Figueiredo Júnior Hélcio 
Published: December 2022

A demência trata-se de uma síndrome que possui um curso lento, de natureza crônica e progressiva, sendo a doença de Alzheimer (DA) o subtipo mais comum, ou seja, corresponde a maioria dos casos diagnosticados. O objetivo geral do presente artigo foi estudar as consequências e impactos da DA na vida dos idosos e seus familiares. Para tanto foi realizada uma pesquisa bibliográfica onde foram selecionados autores que fundamentassem o objetivo proposto. O estudo contou com 20 autores rastreados em Bases de Dados Virtuais como SciELO, BVS, LILACS e Google Scholar, além de 3 livros. Observou-se que tanto o idoso com DA quanto seus familiares sofrem uma queda na sua qualidade de vida, por estarem enfrentando situações limites, na maioria das vezes desconhecidas.
Palavras-Chave: Doença de Alzheimer; Qualidade de Vida; Consequências e Impactos
Abordagem a Icterícia Neonatal: Fototerapia e práticas terapêuticas alternativas associadas: uma revisão de literatura
Authors: Machado Antunis Ribeiro Adrielly , Rocha Salim Thais , Rodrigues Ana Carolina , De Souza Pena Victor , Moreira Penedo Mariana , De Oliveira Campos Mariana 
Published: December 2022

Icterícia se caracteriza por ser a manifestação clínica de evolução craniocaudal mais comum observada nos recém-nascidos (RNs), dividida em fisiológico, patológico e associada ao aleitamento materno, incluindo-se nesta última categoria tanto a falha quanto continuidade. O objetivo desta revisão foi analisar a abordagem terapêutica à icterícia neonatal e identificar os principais fatores de risco para o desenvolvimento e progressão dessa. Foi realizada uma busca por trabalhos prévios nas plataformas SciELO, Lilacs e PubMed,os descritores utilizados foram: “ neonatal jaundice ” ,“ phototherapy” , “ treatment” e “ hyperbilirubinemia”, e um total de 27 artigos científicos foram incluídos após a aplicação de critérios de inclusão e exclusão, dentro dos critérios de inclusão estão: artigos originais, publicados nos últimos 10 anos, nos idiomas inglês, português, e espanhol; de acesso livre com delineamento experimental e observacional, coletados até o mês de fevereiro de 2021. Já os critérios de exclusão consistem em: artigos duplicados, aqueles em que os descritores não estavam relacionados, artigos que não se referiam ao tema exposto e artigos que não incluiam a fototerapia como tratamento. Através dos estudos analisados foi observado que o desenvolvimento da icterícia está mais frequentemente associadas com a prematuridade e a alta hospitalar precoce,em que fototerapia e a continuidade do aleitamento materno foram os principais tratamentos relatados, fatores que devem ser reconhecido pelos profissionais de saúde a fim de saber avaliar a melhor forma de abordar esses pacientes, diminuindo a taxa de readmissão. Em conclusão, tratamento da icterícia neonatal com fototerapia associado a outro método alternativo pode ser benéfico para o recém-nascido.
PCSK9 Biomarker and Key Modulator for Cardiovascular Disorders:
Heralding a New Therapeutic Era and Their Future Perspectives
Authors: Gupta Jitendra , Gupta Reena 
Published: December 2022

Abstract:
Cardiovascular disorders (CVDs) are the leading cause of death worldwide and are
accelerated via the low level of low-density lipoprotein-cholesterol (LDL-C). The proprotein
convertase subtilis/kexin type9 (PCSK9), a vital regulator and a biomarker, circulates for the
LDL-C and has the degradation capability of the low-density lipoprotein receptor (LDLR).
PCSK9 has modulated the overall mechanism by transcription, secretion, clearance, or extracellular
inactivation in the past few years.PCSK9 has specific pathophysiological roles in many cardiovascular
cells. The initial data on the PCSK9 inhibitor, Evolocumab, has a specific reduction
in the composite end-point, such as cardiovascular, myocardial, and stroke, while the rest of the
data release is still under wait. Furthermore, it is witnessed that the U.S. and the European authorities
have approved two humanized antibodies against the LDL-R binding site of PCSK9.
This review highlighted the recent data findings on the PCSK9 and its regulation, focusing on
cardiovascular disorders, and summarized the current clinical studies. Thus it provides a ray of
hope to overcome statin intolerance and alternative approaches for PSCK9 inhibition and significantly
reduce cardiovascular complications. This review plays a pivotal role for the researchers
and scientists working on PCSK9 inhibitors to treat cardiovascular disorders.
How TikTok Is Being Used to Help Individuals Cope With Breast Cancer: Cross-sectional Content Analysis
Authors: Basch Corey H , Hillyer Grace C , Yalamanchili Bhavya , Morris Aldean 
Published: December 2022

Background
Acknowledging the popularity of TikTok, how quickly medical information can spread, and how users seek support on social media, there is a clear lack of research on breast cancer conversations on TikTok. There is a paucity of information on how these videos can advocate for those impacted by breast cancer as a means to provide support and information as well as raise awareness.

Objective
The purpose of this cross-sectional content analysis was to describe the content of videos from the hashtag #breastcancer on TikTok. Content related to breast cancer support and coping, cancer education, and heightening the awareness of breast cancer early detection, prevention, and treatment was evaluated.

Methods
This study included 100 of the most viewed TikTok videos related to breast cancer through June 30, 2022. Videos were excluded if they were not in the English language or relevant to the topic being studied. Content was deductively coded into categories related to video characteristics and content topics using a screener based on expert breast cancer information sheets. Univariable analyses were conducted to evaluate differences in video characteristics and content when stratified as advocating or not advocating for breast cancer (yes or no) support, education, and awareness.

Results
The cumulative number of views of the videos included in this study was 369,504,590. The majority (n=81, 81%) of videos were created by patients and loved ones of individuals with breast cancer, and the most commonly discussed topic was breast cancer support (n=88, 88%), followed by coping with the myriad issues surrounding breast cancer (n=79, 79%). Overall, <50% of the videos addressed important issues such as body image (n=48, 48%), surgery (n=46, 46%), medication and therapy (n=41, 41%), or the stigma associated with a breast cancer diagnosis (n=44, 44%); however, in videos that were advocacy oriented, body image (40/62, 64% vs 8/38, 21%; P<.001), stigma associated with breast cancer (33/62, 53% vs 11/38, 29%; P=.02), and breast cancer surgery (36/62, 58% vs 10/38, 26%; P=.002) were discussed significantly more often than in videos that did not specifically advocate for breast cancer.

Conclusions
The use of videos to display health journeys can facilitate engagement by patients, family members, and loved ones interested in information about challenging conditions. Collectively, these findings highlight the level of peer-to-peer involvement on TikTok and may provide insights for designing breast cancer educational campaigns.
Tau as a fluid biomarker of concussion and neurodegeneration
Authors: Hossain Iftakher , Blennow Kaj , Posti Jussi P , Zetterberg Henrik 
Published: December 2022

Concussion is predominant among the vast number of traumatic brain injuries that occur worldwide. Difficulties in timely identification, whether concussion led to neuronal injury or not, diagnosis and the lack of prognostic tools for adequate management could lead this type of brain injury to progressive neurodegenerative diseases. Tau has been extensively studied in recent years, particularly in repetitive mild traumatic brain injuries and sports-related concussions. Tauopathies, the group of neurodegenerative diseases, have also been studied with advanced functional imaging. Nevertheless, neurodegenerative diseases, such as chronic traumatic encephalopathy, are still conclusively diagnosed at autopsy. Here, we discuss the diagnostic dilemma and the relationship between concussion and neurodegenerative diseases and review the literature on tau as a promising biomarker for concussion.
The effect of medical respite services on hospital readmissions for those experiencing homelessness
Authors: Belardo Kendrick 
Published: December 2022

A clinical decision report using:
Kertesz SG, Posner MA, O’Connell JJ, et al. Post-Hospital Medical Respite Care and Hospital Readmission of Homeless Persons. J Prev Interv Community. 2009;37(2):129-142. https://doi.org/10.1080/10852350902735734
for a patient experiencing homelessness.
Renal replacement therapy could be initiated in patients with severe AKI, regardless of age and critical condition
Authors: Shamsa El Hussain 
Published: December 2022

A clinical decision report using:
Meersch M, Küllmar M, Schmidt C, et al. Long-Term Clinical Outcomes after Early Initiation of RRT in Critically Ill Patients with AKI. J Am Soc Nephrol. Mar 2018;29(3):1011-1019. https://doi.org/10.1681/asn.2017060694
for a critically ill elderly patient with severe acute kidney injury.
Design of Influent Distribution System in Domestic Wastewater Treatment Units
Authors: Macías Astrid L. , Rodríguez Diana C. , Molina Francisco J. 
Published: December 2022

The efficient treatment of domestic wastewater is associated with good operational practices in wastewater treatment plants (WWTP) and the proper design of each treatment unit, which ensures the correct hydraulic performance of each WWTP. For this reason, the objective of this article was to study the design of the multiple influent distribution systems of a high-rate primary sedimentary, a UASB (Upflow Anaerobic Sludge Blanket) reactor, and an up-flow anaerobic filter (FAFA) in the WWTPs of the municipalities of San Carlos and San Roque, and in the township of Santiago, respectively, located in Antioquia-Colombia. For this purpose, the methodology proposed by Hudson in 1981 was used to evaluate the performance of the current design and, subsequently, a pre-dimensioning was carried out to distribute the flow uniformly, to have velocities within the ranges recommended by the literature, and to obtain the total head loss generated by the distribution manifold in each treatment unit evaluated. It was found that the existing design is not efficient and that the new pre-dimensioning ensures homogeneous flow distribution and provides velocities that contribute positively to the treatment process. The study concludes that the smaller the number of orifices and the larger the pipe diameter, the more uniform the flow distribution, and that the total head loss depends on both the velocity head and the head loss coefficient. The diameter of the orifice was the predominant parameter to control the inlet velocity of the treatment units.
Leadless versus Transvenous Single-Chamber Ventricular Pacemakers: Three Year Follow-Up of the Micra CED Study
Authors: Crossley George , Piccini Jonathan , Longacre Colleen , Higuera Lucas , Stromberg Kurt , El-Chami Mikhael 
Published: December 2022

Background: The Micra Coverage with Evidence Development (CED)
Study is a novel comparative analysis of Micra (leadless VVI) and
transvenous single-chamber ventricular pacemakers (transvenous VVI)
using administrative claims data. Objective: To compare chronic
complications, device reinterventions, heart failure hospitalizations,
and all-cause mortality after 3 years of follow-up. Methods:
U.S. Medicare claims data linked to manufacturer device registration
information were used to identify Medicare beneficiaries with a de
novo implant of either a Micra VR leadless VVI or transvenous VVI
pacemaker from March 9, 2017-December 31, 2018. Unadjusted and
propensity score overlap-weight adjusted Fine-Gray competing risk models
were used to compare outcomes at 3 years. Results: Leadless
VVI patients (N=6,219) had a 32% lower rate of chronic complications
and a 41% lower rate of reintervention compared with transvenous VVI
patients (N=10,212) (chronic complication hazard ratio [HR] 0.68;
95% CI, 0.59-0.78; reintervention HR 0.59; 95% CI 0.44-0.78).
Infections rates were significantly lower among patients with a leadless
VVI (<0.2% versus 0.7%, P<0.0001). Patients with a
leadless VVI also had slightly lower rates of heart failure
hospitalization (HR 0.90; 95% CI 0.84-0.97). There was no difference in
the adjusted 3-year all-cause mortality rate (HR 0.97; 95% CI,
0.92-1.03). Conclusion: This nationwide comparative evaluation
of leadless VVI versus transvenous VVI de novo pacemaker implants
demonstrated that the leadless group had significantly fewer
complications, reinterventions, heart failure hospitalizations, and
infections than the transvenous group at 3 years, confirming that the
previously reported shorter-term advantages associated with leadless
pacing persist and continue to accrue in the medium-to-long-term.
The Gestalt Whitehead
Authors: Desmet Ronny 
Published: December 2022

Abstract
The aim of the first part of this article is to highlight some of the historical roots of the affinities of Whitehead’s philosophy with Gestalt psychology by identifying a number of physicists as well as philosopher-psychologists playing a relevant role in both the genesis of Whitehead’s thought and that of Gestalt psychology. The article goes beyond identifying Faraday and Maxwell as well as James and Bergson as relevant in this respect. It also focuses on others who have influenced Whitehead: Lorentz as well as Lotze and Brentano, Ward and Stout. The aim of the second part of this article is to introduce three of Whitehead’s key ideas by means of a number of simple Gestalt experiments: his idea of what mathematics is all about, his idea of what is wrong with Einstein’s interpretation of special and general relativity, and his idea of the role of recognition in the subjective form of feeling.
Process Ethics and Business: Applying Process Thought to Enact Critiques of Mind/Body Dualism in Organizations
Authors: Macklin Rob , Mathison Karin , Dibben Mark 
Published: December 2022

Abstract
The study of organizational ethics continues to be the focus of significant academic attention, however it is a discourse that remains largely informed by a form of morality that is perhaps best described as ordered and cognitive. Traditional approaches to questions of organizational ethics emphasize a fundamentally static view of organizations and the people within them, reinforcing notions of mind/body dualism and reifying ethics as an outcome of human agency, choice, and deliberate intention (see MacKay and Chia). We challenge this approach and instead argue in favor of ethics research that adopts an ontology grounded in process metaphysics. Escaping the confines of Cartesian dualism, we reconceptualize organizational ethics as something that is in fact not held constant, is not a static termination point or an outcome of events, but is rather an input into the continually reconstituting context of the organization over time (see Langley, et al). The process ethics we articulate provides a grounding for moral critique in diverse communities that is not undermined by relativism. Moreover, it provides guidance to managers and employees facing moral problems without forcing them to face a tyranny of principles. We consider how a process ethics would be enacted in organizations through managerial decision-making and in the treatment of employees.
THE DEPTHS OF COMPASSION
Authors: Buchanan John H. 
Published: December 2022

Abstract
Some notion of compassion must play a central role in conceiving of a true process psychology. In Whitehead’s metaphysics, "feeling the feelings of others" is how reality itself is constructed. By placing primitive feeling at the heart of perception, experience, and the nature of reality, process philosophy helps psychology envision compassion as a way of connecting directly to the depths of others, of nature, and of ourselves. This paper focuses on some deeper experiences of compassion, as elucidated by transpersonal psychology, and how these spiritual experiences might be accessed and utilized in these challenging times.
"A Dialectic of Contrasts": Robert Duncan and Denise Levertov’s Ecological Writing
Authors: Hoeynck Joshua S. 
Published: December 2022

Abstract
"A Dialectic of Contrasts" details how the mid-twentieth century American poets Robert Duncan and Denise Levertov employed their understanding of Whitehead’s notion of "contrast" to imagine poems closely linked to ecology and cosmology. Exploring the references to Whitehead’s heterogeneous dialectic of contrasts in the Duncan/Levertov correspondence, the article displays the forcible role Whitehead’s thought played in directing the two poets to a linguistic-organic poetics invested in nonhuman agency.
A Response to G.B. Bagci’s "Ghirardi-Rimini-Weber Collapse Theory and Whiteheadian Process Philosophy"
Authors: Kallfelz William M. 
Published: December 2022

Abstract
I examine G.B. Baga’s arguments for the Ghirardi-Rimini-Weber (GRW) interpretation of non-relativistic quantum mechanics as ideally suited for Whitehead’s philosophy. Much of Bagci’s claims are in response to Michael Epperson, who argues in the same vein in favor of decoherence accounts (Omnès; Zureck). Pace Epperson, I do not think that decoherence is the final arbiter here, and instead I contrast GRW with several other accounts addressing foundational problems of quantum theory (Finkehtein; Green; Peres and Temo; etc.), which aho account for relativistic covariance, while GRW does not. I argue that such latter research programs align themselves in a more convincing manner with Whitehead’s scheme, in epistemic as well as metaphysical senses, than GRW.
Process Ecology: Philosophy Passes into Praxis
Authors: Ulanowicz Robert E. 
Published: December 2022

Abstract
Mechanical reductionism, which deals entirely with homogeneous variables, will constrain and enable the activities of richly heterogeneous living systems, but it cannot determine their outcomes. Such indeterminism owes to problems with dimensionality, dynamical logic, intractability, and insufficiency. The order in any living structure arises via an historical series of contingencies that were selected endogenously by stable autocatalytic processes in tandem with, and usually in opposition to, conventional external influences (natural selection). The development of living communities thereby resembles a Heraclitean dialectic between processes that build up and those that tear down. Investigating this unconventional dynamic requires metaphysical assumptions that are complementary to those that have guided science over the past three centuries. The new dynamics can be represented in terms of weighted networks of interacting processes, which facilitate the statement of testable hypotheses. Network analysis thereby implements and tests ideas that heretofore could only be addressed as verbal propositions.
Whiteheadian Societies as Open-Ended Systems and Open-Ended Systems as Whiteheadian Societies
Authors: Bracken Joseph A. 
Published: December 2022

Abstract
In this essay I defend two interrelated theses. The first is that Whiteheadian structured societies are best understood as open-ended systems akin to those currently being proposed in the natural and social sciences by Stuart Kauffman, David Sloan Wilson, and Niklas Luhmann. The second is that an open-ended system is best understood in terms of an ongoing interplay of subjectivity and objectivity, which I derive from a modest rethinking of the workings of a Whiteheadian structured society.
Cosmos, Logos, and the Limits of Science
Authors: Valenza Robert J. 
Published: December 2022

Abstract
Following the introduction of the special and general theories of relativity and development of consequent cosmological models, the extent to which time and space play a starkly abstract role in physics has become more and more apparent. We examine here whether the full force of such abstract characterizations comes ultimately into opposition with the practice of science and implies some hard limitations on the scope of scientific discourse.
The Categoreal Scheme in Hua-yan Buddhism and Whitehead’s Metaphysics
Authors: Yu Yih-hsien 
Published: December 2022

Abstract
If, after a century of analysis there is a turn to synthesis, Hua-yan and Whitehead will become important resources. Especially given the radical difference of their historical contexts, their similarity is striking, but they differ on time. Whitehead is clear that relations to the future always differ in kind from those to the past, and Theravada Buddhists agree. But Hua-yan is open to a greater symmetry in enlightened experience.
Whitehead, Buddhism, and the Reversibility of Time
Authors: Yokota John Shunji 
Published: December 2022

Abstract
Pure Land Buddhism ascribes to Amida some of the roles ascribed to God by Whitehead. The failure of Whiteheadians to clarify how God can play these roles also leaves doubtful the claim of Pure Land Buddhism. On the other hand, Whitehead’s emphasis on perpetual perishing reinforces the original Buddhist teaching of impermanence and together they provide the basic insight for authentic life.
Death and the Dipolar Category of the Ultimate
Authors: Voskuil Duane 
Published: December 2022

Abstract
If the Category of the Ultimate requires every actual entity to be, as Whitehead says, both a processing subject and a superject existing objectively immortal, death of a personally ordered social nexus seems impossible since a personal nexus cannot die unless it has a last member. How that is possible is examined, concluding that actual entities of necessarily existing personal societies always have enough creative power to integrate their physical prehensions into new satisfaction/superjects, but others in contingently existing personal societie inevitably do not.
Introducing a Time Horizon into Ethics
Authors: Hayashi Yoshihiro 
Published: December 2022

Abstract
Modern technology has radically altered the conditions for human action, endowing us with tremendous power to affect the future. Patterns of action that appear positive in their short-term effects must sometimes be judged unsustainable. Hans Jonas and Thomas Berry are among those who emphasize the necessity of transforming ethics in light of these considerations. In a Whiteheadian framework, this needed transformation is rooted in the nature of things.
Between Hartshorne and Molina: A Whiteheadian Conception of Divine Foreknowledge
Authors: Malone-France Derek 
Published: December 2022

Abstract
The doctrine of inerrant divine "middle knowledge" of future contingent events, first developed by the sixteenth century Jesuit theologian Luis de Molina, has resurfaced as a prominent position within contemporary debates over divine foreknowledge, creaturely freedom, and the ontological status of possibilities. As yet, the only substantive response to the new Molinism from a process perspectiv has come in a brief section on "Hartshorne and the Challenge of Molinism," in an essay on Hartshorne’s view of "The Logic of Future Contingents" by George W. Shields and Donald W. Viney, in Shields’ edited anthology Process and Analysis. Shields and Viney offer an insightful critique of Molinism. However, their use of Hartshorne’s understanding of possibility presents problems for those, like me, who prefer Whitehead’s more robustly realist notion of eternal objects. Here, I defend Whitehead’s Platonism from the main lines of criticism leveled against it by Hartshorne, while demonstrating that a "thick" conception of the objective content of the possible within the context of the divine understanding need not cross over into a deterministic conception of God’s foreknowledge, à la Molina.