bluuebunny/crossref_metadata_2025_split huggingface dataset:
New polyamides based on diacid with decanediamide and methylene groups and aromatic diamines
Authors: Diwate Arati V. , Tamboli Asiya M. , Ghodke Shivaji D. , Tamboli Aslam B. , Tamboli Mohaseen S. , Maldar Noormahamad N. 
Published: February 2022

AbstractA new aromatic diacid, containing preformed diamide functional group, C8 alkylene moiety, and two methylene spacers, viz; N, N′‐bis(4′‐carboxy methylene phenyl) decane diamide (BCPDD) was designed and successfully synthesized. The structure of BCPDD was confirmed by FT‐IR, NMR (1H, 13C) spectroscopy and mass spectrometry. The corresponding series of new polyamides were prepared via reactions of diacid (BCPDD) and commercial aromatic diamines by Yamazaki's phosphorylative direct polycondensation method. Physical properties of these polyamides such as inherent viscosity, solubility in organic solvents, glass transition temperatures by DSC, thermal stability by TGA, and amorphous‐crystalline mature by XRD were studied. The incorporation of preformed amide, methylene spacers, and C8 alkylene moiety greatly affected polyamide properties such as solubility in common organic polar solvents, glass transition temperature, and thermal stability. These polyamides were mostly amorphous in nature and dissolved in polar aprotic solvents such as N‐methyl‐2‐pyrrolidone, N, N‐dimethylacetamide, N, N‐dimethylformamide, dimethyl sulfoxide, m‐cresol, and pyridine. Inherent viscosities of these polyamides were in the range of 0.40–0.67dL/g; indicating the formation of moderate to high molecular weights. These polyamides exhibited good thermal stability having temperatures for 10% weight loss (T10) in the range of 404–578°C and the char yields at 800°C in the range of 35–65%. The glass transition temperatures; as determined by DSC were in the range of 204–235°C.
Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast‐like Synoviocytes
Authors: Torres Alyssa , Pedersen Brian , Cobo Isidoro , Ai Rizi , Coras Roxana , Murillo‐Saich Jessica , Nygaard Gyrid , Sanchez‐Lopez Elsa , Murphy Anne , Wang Wei , Firestein Gary S. , Guma Monica 
Published: February 2022

ObjectiveSince previous studies indicate that metabolism is altered in rheumatoid arthritis (RA) fibroblast‐like synoviocytes (FLS), we undertook this study to determine if changes in the genome‐wide chromatin and DNA states in genes associated with nutrient transporters could help to identify activated metabolic pathways in RA FLS.MethodsData from a previous comprehensive epigenomic study in FLS were analyzed to identify differences in genome‐wide states and gene transcription between RA and osteoarthritis. We utilized the single nearest genes to regions of interest for pathway analyses. Homer promoter analysis was used to identify enriched motifs for transcription factors. The role of solute carrier transporters and glutamine metabolism dependence in RA FLS was determined by small interfacing RNA knockdown, functional assays, and incubation with CB‐839, a glutaminase inhibitor. We performed 1H nuclear magnetic resonance to quantify metabolites.ResultsThe unbiased pathway analysis demonstrated that solute carrier–mediated transmembrane transport was one pathway associated with differences in at least 4 genome‐wide states or gene transcription. Thirty‐four transporters of amino acids and other nutrients were associated with a change in at least 4 epigenetic marks. Functional assays revealed that solute carrier family 4 member 4 (SLC4A4) was critical for invasion, and glutamine was sufficient as an alternate source of energy to glucose. Experiments with CB‐839 demonstrated decreased RA FLS invasion and proliferation. Finally, we found enrichment of motifs for c‐Myc in several nutrient transporters.ConclusionOur findings demonstrate that changes in the epigenetic landscape of genes are related to nutrient transporters, and metabolic pathways can be used to identify RA‐specific targets, including critical solute carrier transporters, enzymes, and transcription factors, to develop novel therapeutic agents.
Organosulfur/Selenium‐Based Highly Fluorogenic Molecular Probes for Live‐Cell Nucleolus Imaging
Authors: Mondal Iswar Chandra , Galkin Maksym , Sharma Shubham , Murugan N. Arul , Yushchenko Dmytro A. , Girdhar Khyati , Karmakar Anirban , Mondal Prosenjit , Gaur Pankaj , Ghosh Subrata 
Published: February 2022

AbstractWe present fluorogenic cationic organo chalcogens that are highly selective to RNA. We have demonstrated that the conformational dynamics and subsequently the optical properties of these dyes can be controlled to facilitate efficient bioimaging. We report the application of organoselenium and organosulfur‐based cell‐permeable red‐emissive probes bearing a favorable cyclic sidearm for selective and high contrast imaging of cell nucleoli. The probes exhibit high quantum yield upon interacting with RNA in an aqueous solution. An in‐depth multiscale simulation study reveals that the prominent rotational freezing of the electron‐donating sidearm of the probes in the microenvironment of RNA helps in attaining more planar conformation when compared to DNA. It exerts a greater extent of intramolecular charge transfer and hence leads to enhanced fluorescence emission. A systematic structure‐interaction relationship study highlighted the impact of heavy‐chalcogens toward the improved emissive properties of the probes.
Dendrite‐Free Zinc Deposition Induced by Zinc‐Phytate Coating for Long‐Life Aqueous Zinc Batteries
Authors: Du Leilei , Hou Xu , Yang Xiaofei , Siozios Vassilios , Yan Bo , Ju Xiaokang , Paillard Elie , Winter Martin , Placke Tobias , Li Jie 
Published: February 2022

AbstractRechargeable aqueous zinc batteries (AZBs) have been recognized as attractive energy storage devices because of their intrinsic superiorities, e. g., high safety, low material cost and environmental benignity. However, challenges such as dendrite formation on the surface of zinc (Zn) anode, poor reversibility of Zn plating/stripping and short circuit of the cell, having detrimental impact on cycle life and safety, hinder their further development. Herein, we design an artificial solid electrolyte interphase (SEI) layer for the Zn anode by coating it with a zinc‐phytate (ZP) layer via a facile acid‐etching approach. The symmetric cell with a modified Zn electrode exhibits excellent cycling stability and a low polarization voltage, since the ZP layer can guide uniform Zn deposition under the layer without dendrite formation and maintain a smooth interface between separator and electrode, which suggests Zn2+ transport properties of the coating layer. Moreover, comparing full cells, one employing a bare Zn anode (MnO2/carbon nanofibers (CNFs)||Zn), with the other with a modified Zn anode (MnO2/CNFs||ZP−Zn), the MnO2/CNFs||ZP−Zn cell delivers much better long‐term cycling stability (capacity retention after 1000 cycles of 130 mAh g−1 vs. 50 mAh g−1 at a specific current of 0.5 A g−1). The coating via acid etching method offers a new powerful technique for further development of practical AZBs.
Evaluation of an elective ultrasound course for medical students
Authors: Kloth Christopher , Schmidt Stefan Andreas , Graeter Tilmann , Nikolaou Konstantin , Kaufmann Sascha , Beer Meinrad , Thaiss Wolfgang Maximilian 
Published: February 2022

AbstractTo evaluate the educational benefits of teaching ultrasound in an elective radiological course for medical students. We conducted a single‐center retrospective analysis of a one‐week elective ultrasound course in which 39 medical students (25 female; median age 25.8 ± 2.8 years, range 21–35, 4th and 5th years of undergraduate medical education) participated as part of their radiological training. The students completed a pre‐ and post‐course questionnaire using a five‐point Likert scale for self‐assessment of technical knowledge, confidence in the procedure regarding different organs, motivation for performing ultrasound, and the importance of ultrasound in medical education. The students also assessed the value of ultrasound teaching in the context of their general medical degree. Pre‐test and post‐test scores showed significantly improved radiology knowledge (p ≤ 0.001) concerning all abdominal organs (liver, spleen, gallbladder, kidney, urinary bladder, aorta and retroperitoneum). A significant improvement was registered in performing ultrasound of peripheral arteries and venous structures (each p = 0.001), and also of the thyroid gland (p = 0.006). General surveys at the end of the elective were overwhelmingly positive, with constructive criticism and complimentary comments. Systematic training in ultrasound markedly improved the students' skills. This was especially pronounced for solid organ structures, while students requested more education regarding the retroperitoneum and vascular structures. Teaching ultrasound in an elective hands‐on training course improves anatomical understanding and practical skills associated with increased motivation. The results affirm the necessity and clinical relevance of the course during the radiological training of medical students.
A novel LASSO‐derived prognostic model predicting survival for non‐small cell lung cancer patients with M1a diseases
Authors: Chen Hongchao , Huang Chen , Ge Huiqing , Chen Qianshun , Chen Jing , Li Yuqiang , Chen Haiyong , Luo Shiyin , Zhao Lilan , Xu Xunyu 
Published: February 2022

AbstractIntroductionThe current American Joint Committee on Cancer (AJCC) M1a staging of non‐small cell lung cancer (NSCLC) encompasses a wide disease spectrum, showing diverse prognosis.MethodsPatients who diagnosed in an earlier period formed the training cohort, and those who diagnosed thereafter formed the validation cohort. Kaplan–Meier analysis was performed for the training cohort by dividing the M1a stage into three subgroups: (I) malignant pleural effusion (MPE) or malignant pericardial effusion (MPCE); (II) separate tumor nodules in contralateral lung (STCL); and (III) pleural tumor nodules on the ipsilateral lung (PTIL). Gender, age, histologic, N stage, grade, surgery for primary site, lymphadenectomy, M1a groups, and chemotherapy were selected as independent prognostic factors using the least absolute shrinkage and selection operator (LASSO) Cox regression analysis. And a nomogram was constructed using Cox hazard regression analysis. Accuracy and clinical practicability were separately tested by Harrell's concordance index, the receiver operating characteristic (ROC) curve, calibration plots, residual plot, the integrated discrimination improvement (IDI), net reclassification improvement (NRI), and decision curve analysis (DCA).ResultsThe concordance index (0.661 for the training cohort and 0.688 for the validation cohort) and the area under the ROC curve (training cohort: 0.709 for 1‐year and 0.727 for 2‐year OS prediction; validation cohort: 0.737 for 1‐year and 0.734 for 2‐year OS prediction) indicated satisfactory discriminative ability of the nomogram. Calibration curve and DCA presented great prognostic accuracy, and clinical applicability. Its prognostic accuracy preceded the AJCC staging with evaluated NRI (1‐year: 0.327; 2‐year: 0.302) and IDI (1‐year: 0.138; 2‐year: 0.130).ConclusionOur study established a nomogram for the prediction of 1‐ and 2‐year OS in patients with NSCLC diagnosed with stage M1a, facilitating healthcare workers to accurately evaluate the individual survival of M1a NSCLC patients. The accuracy and clinical applicability of this nomogram were validated.
Risk factors for venous thromboembolism in metastatic colorectal cancer with contemporary treatment: A SEER‐Medicare analysis
Authors: Ades Steven , Pulluri Bhargavi , Holmes Chris E. , Lal Inder , Kumar Santosh , Littenberg Benjamin 
Published: February 2022

AbstractBackgroundThe relationship between metastatic colorectal cancer (mCRC) and venous thromboembolism (VTE) is poorly defined in the modern era. Our objective was to examine impact of putative risk factors including newer treatments and anti‐angiogenic therapy on VTE incidence and survival in a modern older mCRC cohort.MethodsThis is a SEER‐Medicare cohort analysis of mCRC patients diagnosed in 2004–2009. Risk factor analysis was conducted using Cox models adjusted for sex, diagnosis age, race, primary tumor location, comorbidity, and prior VTE history, with cancer treatments as time‐varying covariates. Main outcomes were VTE incidence and overall survival.ResultsTen thousand nine hundred and seventy six mCRC cases with mean age 77.9 years (range 65–107), 49.7% women, 83.5% white. There were 1306 VTE cases corresponding to 13.7% incidence at 1 year and 20.3% at 3 years. Independent VTE predictors included female sex (HR 1.27; 95% CI 1.14–1.42), African American race (HR 1.49; 1.27–1.73), prior VTE history (HR 16.3; 12.1–22.1), and right sided cancers (HR 1.16; 1.04–1.29). After adjustment, any therapy and bevacizumab (HR 0.68, 0.58–0.78) in particular were protective. Overall survival was 40.1% (39.4–41.3) at 1 year but improved significantly with any treatment. VTE following diagnosis of mCRC was associated with inferior OS (HR 1.09; 1.02–1.15).ConclusionsIn this large contemporary mCRC cohort, effective systemic therapy including anti‐angiogenic treatment was associated with lower VTE risk. Overall survival was poor, and modestly worse if a patient had a VTE at any time during treatment.
The outcome of watchful waiting in patients with previously treated follicular lymphoma
Authors: Fujino Takahiro , Maruyama Dai , Maeshima Akiko‐Miyagi , Saito Yo , Ida Hanae , Hosoba Rika , Yuda Sayako , Makita Shinichi , Fukuhara Suguru , Munakata Wataru , Suzuki Tatsuya , Kuroda Junya , Izutsu Koji 
Published: February 2022

AbstractWatchful waiting (WW) is one of the standard approaches for newly diagnosed follicular lymphoma (FL) patients with low‐tumor burden. However, the impact of WW in FL patients at the first progression, remains unclear. We reviewed 206 FL patients who experienced the first progression after responding to the initial treatment at our institution between 1998 and 2017. Patients were classified into either the WW cohort (132 patients) or the immediate treatment cohort (74 patients). Overall, the median follow‐up from the first progression was 79.8 months (range, 2.1–227.0 months). In the WW cohort, the estimated median time to next treatment (TNT) was 19.7 months (95% confidence interval [CI], 13.4–30.2), and 76.5% (95% CI, 68.0–84.1) of the patients subsequently underwent the second‐line treatment at 5 years. There was a significant difference in the median time to treatment failure in the WW cohort (72.8 months; 95% CI, 64.6–94.0) compared to the immediate treatment cohort (23.3 months; 95% CI, 13.4–38.8) (HR, 2.13; 95% CI, 1.48–3.06), whereas overall survival and the cumulative incidence of histological transformation were not significantly different between two cohorts. In a multivariate analysis, rituximab refractory status, progression of disease within 24 months from the induction of first‐line therapy, and a high Follicular Lymphoma International Prognostic Index score at diagnosis were significantly associated with shorter TNT. Interestingly, 15 patients (11%) of the WW cohort experienced spontaneous tumor regression during WW, and their TNT (median, 82.1 months, 95% CI, 11.7‐NA) was longer than that of the remaining patients in the WW cohort (median, 16.5 months, 95% CI, 13.0–25.4), with a significant difference (p = 0.01). The results of the present study suggested that WW could be a safe and reasonable option even at the first progression for the selected FL patients, without a negative impact on clinical outcomes.
Relationship between protein structure and eating quality of rice under different nitrogen application rate
Authors: Liang Hanling , Gu Baiyu , Wang Tianyu , Rong Liyan , Sun Wentao , Wu Zhaoxia 
Published: February 2022

AbstractBackground and ObjectivesThe mechanisms underlying the effects of proteins on the eating quality of rice remain elusive. In this study, the effect of content and secondary structure of four rice proteins (glutelin, globulin, albumin, and prolamin) on eating quality was investigated with rice subjected to nitrogen treatment at 160, 210, 260, 315, and 420 kg N/ha in the field.FindingsThe results showed that applying nitrogen fertilizer remarkably increased glutelin and globulin contents (p < .05), especially the methionine content of globulin, leading to increased hardness of cooked rice. Moreover, excessive nitrogen significantly reduced the ratio of the prolamin α‐helix structure (p < .05), which had a significant correlation with hardness and pasting temperature (p < .05), at correlation coefficients of −0.859 and 0.828, respectively.ConclusionBesides protein content, the changes in amino acid content and protein secondary structure were also closely related to the eating quality of rice.Significance and NoveltyThose results provided a new idea for breeding, cultivating, and processing technology regulation aimed at improving the eating quality of rice.
Uncommon manifestation of poisoning with a mixture of pesticides
Authors: Zoofaghari Shafeajafar , Namakizadeh Esfahani Navid , Akhavan Sigari Amirhossein , Tavakoli Nasim , Hashemzadeh Mozhdeh , Eizadi‐Mood Nastaran 
Published: February 2022

AbstractThe ingestion of pesticides for suicide commitment purposes is common in developing countries. We present a case of suicide with ingestion of mixed pesticides. The autopsy findings showed the presence of diazinon, chlorpyrifos, trifluralin, fenpropathrin, pyriproxyfen, and cypermethrin in his body. Clinicians managing poisoning cases need to be aware of poisoning with mixture of pesticides as a rare but highly fatal outcome.
Keratosis obturans: A rare cause of facial nerve palsy
Authors: Poudyal Prasanta , Nepal Gaurav , Yadav Sushil Kumar , Neupane Yogesh , Dutta Heempali , Pokhrel Shishir , Gaire Prabin 
Published: February 2022

AbstractKeratosis obturans, caused by the deposition of desquamated keratin plug in the external auditory canal can present with facial palsy. Young patients presenting with facial palsy, earache, and gradual hearing loss should be suspected for Keratosis obturans.
Rare complication of a commonly used antihypertensive agent: A case of hydralazine‐induced ANCA‐associated vasculitis presenting as rapidly progressive glomerulonephritis
Authors: Warren Kayle , Vu Khiem , Shergill Karandeep , Watson Brian , Faris Mohamed 
Published: February 2022

AbstractHydralazine‐induced ANCA‐associated vasculitis is a rare clinical entity, with complications including rapidly progressive glomerulonephritis, pulmonary hemorrhage, and pulmonary‐renal syndrome. We present this case to highlight the clinical features that support this challenging diagnosis and to emphasize the importance of prompt recognition and aggressive intervention given its significant morbidity and mortality.
Reactive arthritis and silent thyroiditis following SARS‐CoV‐2 infection: Case report and review of the literature
Authors: Quaytman Jacob , Gollamudi Usha , Bass Noah , Suresh Shashank 
Published: February 2022

AbstractSARS‐CoV‐2 has been implicated in the development of reactive arthritis (ReA) days to weeks following exposure or infection. We present a case of ReA with enthesitis and subsequent silent thyroiditis in a patient following infection with SARS‐CoV‐2, along with a review of the published cases of SARS‐CoV‐2‐related ReA.
Incorporation of Metal Active Sites on Porous Polycarbazoles for Photocatalytic CO2 Reduction
Authors: Wang Wenyan , Xi Yang , Yang Can , Byun Jeehye , Cheng Jiajia , Wang Sibo , Wang Xinchen 
Published: February 2022

AbstractPhotocatalytic conversion of carbon dioxide (CO2) to valuable products is one of the promising approaches to mitigate climate change and provide chemical fuels. The structural design of photocatalysts has been therefore directed to enhancing the CO2 conversion efficiency and selectivity. Herein, we report that the metalated porous polycarbazoles, made by facile one‐pot oxidative polymerization and successive transition metal impregnation, can effectively convert CO2 into carbon monoxide (CO) with high selectivity under visible light irradiation. The high porosity of the porous polycarbazoles provides enhanced CO2 adsorption and the incorporated metals facilitate the CO2 activation. The type of metal ions influences the CO selectivity by altering surface reaction kinetics for CO2 reduction. Our approach proves that the photocatalytic CO2 reduction ability and selectivity of porous conjugated polymers can be improved by decorating functional metal species to modulate the adsorption and activation behavior of CO2 molecules.
Induced Near‐Infrared Emission and Controlled Photooxidation based on Sulfonated Crown Ether in Water
Authors: Dong Xiaoyun , Zhang Cong , Dai Xianyin , Wang Qi , Zhang Ying‐Ming , Xu Xiufang , Liu Yu 
Published: February 2022

AbstractRegulation of physio‐chemical properties and reaction activities via noncovalent methodology has become one of increasingly significant topics in supramolecular chemistry and showed inventive applications in miscellaneous fields. Herein, we demonstrate that sulfonated crown ether can form very stable host‐guest complexes with a series of push‐pull‐type photosensitizers, eventually leading to the dramatic fluorescence enhancement in visible and near‐infrared regions. Meanwhile, severe suppression in singlet oxygen (1O2) production is found, mainly due to the higher energy barriers between the excited single and triple states upon host‐guest complexation. Moreover, such complexation‐induced tuneable 1O2 generation systems has been utilized in adjusting the photochemical oxidation reactions of polycyclic aromatic hydrocarbons (anthracene) and sulfides ((methylthio)benzene) in water. This supramolecularly controlled photooxidation based on the selective molecular binding of crown ether with photosensitizers may provide a feasible and applicable strategy for monitoring and modulating many photocatalysis processes in aqueous phase.
Enantioselective synthesis of indole‐based unnaturalβ‐Alkynylα‐amino acid derivatives via chiral phosphoric acid catalysis
Authors: Woldegiorgis Alemayehu Gashaw , Gu Haorui , Lin Xufeng 
Published: February 2022

AbstractThe synthesis of unnaturalα‐amino acid derivatives has attracted considerable interest in recent years, as they are ubiquitous in protein synthesis and peptide‐based drug discovery. Herein, we reported the chiral phosphoric acid catalyzed asymmetric reaction of indoles withβ,γ‐alkynyl‐α‐imino esters for the enantioselective synthesis of unnatural indole‐basedα‐amino acid derivatives. This asymmetric organocatalysis protocol enables efficient synthesis of unnaturalα‐amino acid derivatives with a tetrasubstituted stereogenic center and an alkyne moiety with up to 99% yield and 98% ee, resulting in operationally simple conditions, short reaction time, and broad substrate scope.