bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-resolution genome-wide association study of a large Czech collection of sweet cherry (Prunus avium L.) on fruit maturity and quality traits
Authors: Holušová Kateřina , Čmejlová Jana , Suran Pavol , Čmejla Radek , Sedlák Jiří , Zelený Lubor , Bartoš Jan 
Published: October 2022

Abstract
In sweet cherry (Prunus avium L.), quantitative trait loci have been identified for fruit maturity, colour, firmness, and size to develop markers for marker-assisted selection. However, resolution is usually too low in those analyses to directly target candidate genes, and some associations are missed. In contrast, genome-wide association studies are performed on broad collections of accessions, and assemblies of reference sequences from Tieton and Satonishiki cultivars enable identification of single nucleotide polymorphisms after whole-genome sequencing, providing high marker density. Two hundred and thirty-five sweet cherry accessions were sequenced and phenotyped for harvest time and fruit colour, firmness, and size. Genome-wide association studies were used to identify single nucleotide polymorphisms associated with each trait, which were verified in breeding material consisting of 64 additional accessions. A total of 1 767 106 single nucleotide polymorphisms were identified. At that density, significant single nucleotide polymorphisms could be linked to co-inherited haplotype blocks (median size ~10 kb). Thus, markers were tightly associated with respective phenotypes, and individual allelic combinations of particular single nucleotide polymorphisms provided links to distinct phenotypes. In addition, yellow-fruit accessions were sequenced, and a ~ 90-kb-deletion on chromosome 3 that included five MYB10 transcription factors was associated with the phenotype. Overall, the study confirmed numerous quantitative trait loci from bi-parental populations using high-diversity accession populations, identified novel associations, and genome-wide association studies reduced the size of trait-associated loci from megabases to kilobases and to a few candidate genes per locus. Thus, a framework is provided to develop molecular markers and evaluate and characterize genes underlying important agronomic traits.
Connected Memories: The International Politics of Partition, from Poland to India
Authors: Goettlich Kerry 
Published: October 2022

Abstract
This article theorizes connected memory, or in other words how people remember each other's memories, through the connected histories of territorial partition in different contexts. It claims that social memories can travel beyond their original context, pushing beyond efforts to understand supranational “mnemonic communities,” or to understand cosmopolitan memory as a thin memory community encompassing all humanity. It builds on the idea of “connected histories,” arguing that existing approaches to social memory in world politics either neglect connections across national and regional boundaries or scale up the national model to the global level. The article uses the history of territorial partitions as an illustration of three types of connected memory: sympathetic, vicarious, and modular. Partition has often been studied in comparative or aggregative ways, ruling out the possibility that partitions affect each other. But from the partitions of Poland to the breakup of the Ottoman Empire, to Ireland, Palestine, and India, partitions have often been events remembered beyond the national context and in the plural. Such memories have, in turn, altered the imaginable possibilities of the future, for example, by providing precedents for or warnings about future partitions.
High-resolution time–frequency analysis based on a synchroextracting adaptive S-transform and its application
Authors: Lin Ying , Chen Siyuan , Zhang Guangzhi , Huang Minmin , Wang Baoli 
Published: October 2022

Abstract
We propose synchroextracting adaptive S-transform (SEAST) by combining the adaptivity provided by the recently introduced ‘Sparse Adaptive S-transform’ (SAST) with the high resolution of synchroextracting spectral decomposition method. Traditional synchroextracting transforms are based on short-time Fourier transforms (STFTs) and their application is limited by having a fixed analysis window size for high and low frequencies and no multi-resolution features. The arbitrary window functions used in the SAST vary with frequency and amplitude, making it more suitable for non-stationary seismic signal analysis. The SEAST retains the multi-resolution advantages of adaptive S-transforms, while providing the strong time–frequency focus associated with synchroextracting transforms. The method was used to calculate seismic dispersion attributes and the resulting field data indicates that its time–frequency resolution and joint P-wave dispersion attributes can help to fine-tune identification of the location of oil and gas reservoirs.
Relationship between labral length and symptoms in patients with acetabular dysplasia before rotational acetabular osteotomy
Authors: Shirogane Yuichi , Homma Yasuhiro , Yanagisawa Naotake , Higano Masanori , Hirasawa Yoichiro , Nakamura Shigeru , Baba Tomonori , Kaneko Kazuo , Taneda Hitoshi , Ishijima Muneaki 
Published: October 2022

ABSTRACTThe aim of this study was to investigate the relationship between acetabular labral length and symptoms in patients with acetabular dysplasia. In a retrospective medical record review, 218 patients with acetabular dysplasia who had undergone rotational acetabular osteotomy were identified. After implementing the inclusion and exclusion criteria, 53 patients were analyzed for preoperative symptoms measured by the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ), acetabular bone morphology parameters by anteroposterior pelvic radiographs and labral parameters by radial magnetic resonance imaging. Spearman’s correlation coefficients were calculated among JHEQ scores, bone morphologic parameters and labral parameters. Multiple linear regression models to determine the predictive variables of JHEQ score and labral length were obtained. There was no correlation between bone morphologic parameters and JHEQ scores. Labral length measured anteriorly correlated with JHEQ pain {r [95% confidence interval (CI)] = −0.335 (−0.555, −0.071), P = 0.014}, movement subscale [r (95% CI) = −0.398 (−0.603, −0.143), P = 0.003], mental subscale [r (95% CI) = −0.436 (−0.632, −0.188), P = 0.001] and total JHEQ score [r (95% CI) = −0.451 (−0.642, −0.204), P = 0.001]. The multiple linear regression results showed that anterior labral length was independently associated with JHEQ subscales in some models. Meanwhile, age, acetabular head index and total JHEQ score were independently associated with anterior labral length in all models. Labral length, notably in anterosuperior area, in patients with symptomatic acetabular dysplasia was related to patient’s symptom. Labral length may be an important objective image finding that can be used to assess the severity of cumulative hip instability.
Infectious Disease Teleconsultation to the Deployed U.S. Military From 2017–2022
Authors: Bennett William N , Markelz Ana E , Kile Michael T , Pamplin Jeremy C , Barsoumian Alice E 
Published: October 2022

ABSTRACT

Introduction
The ADvanced VIrtual Support for OpeRational Forces (ADVISOR) program is a synchronous telemedicine system developed in 2017 to provide 24/7 remote expert support to U.S. Military and NATO clinicians engaged in medical care in austere locations. Infectious disease (ID) remains the highest consulted service since 2018 and is currently staffed by 10 adult and pediatric ID physicians within the Military Health System. We conducted a retrospective review of the ID ADVISOR calls between 2017 and 2022 to identify trends and better prepare military ID physicians to address urgent ID consultations in overseas settings.

Methods
Health records of the ID consultations between July 2017 and January 2022 were reviewed for local caregiver and patient demographics, case descriptions, consultant recommendations, and outcomes. A “not research” determination was made by the Brooke Army Medical Center Human Research Protections Office.

Results
ID physicians received 57 calls for 60 urgent patient consultations. Most calls were from countries in the Middle East or in Southwest Asia (United States Central Command (USCENTCOM)), followed by countries in Africa (United States Africa Command (USAFRICOM)). The majority of patients were active duty U.S. Military and were generally male with median age of 25 years. All consults involved an initial phone consultation and 30% continued over email. Ninety percent of the calls were initiated by physicians, and the median time from injury or illness-onset to consult was 3 days. Seventy percent of the consult questions involved treatment and further diagnostics, but one-third of cases required assistance with management of disease prevention. Multidrug-resistant or nosocomial infections, animal or bite exposure, malaria and malaria prevention, febrile illness, and blood-borne pathogen exposure accounted for 63% of the consults. Collaboration with other specialties took place in a minority of cases, and follow-up contact was recommended 20% of the time. Most recommendations involved adjusting drug regimens or further testing. Medical evacuation was only recommended in five of the cases. Although there was limited ability for follow-up, no known deaths occurred.

Conclusions
A high proportion of calls to the ID ADVISOR line are relevant to the overlapping content areas of infection prevention, force protection, and outbreak response. Most patients requiring urgent ID consultation were managed successfully without evacuation. The current military-unique ID fellowship curriculum is consistent with the encountered diagnoses per the ID ADVISOR line, and high-yield individual topics have been identified.
Intracranial vascular stenosis in giant cell arteritis successfully treated by two balloon angioplasty procedures
Authors: Takatsuki Kensaku , Kojima Yuki , Ikeuchi Yasuhito , Kitayama Jiro , Tanaka Atsushi , Inoue Yasushi 
Published: October 2022

ABSTRACT
Intracranial vascular stenosis is rarely associated with giant cell arteritis (GCA), and the prognosis for stroke caused by GCA is poor. Despite its unfavourable outcome, the strategy to manage this involvement and the indication of endovascular treatment are not well defined in the latest guidelines or recommendations. Here, we present a case in a 68-year-old woman, which was refractory to medical therapy, but successfully treated by two balloon angioplasty procedures. She was admitted to our department with lower extremity stiffness and left visual disturbance. GCA was clinically diagnosed by the wall thickening of the temporal artery and the aorta. Hemiparesis and motor aphasia developed shortly after intravenous methylprednisolone pulse therapy, and magnetic resonance imaging revealed acute cerebral infarction with severe stenosis at the end of the left internal carotid artery. Balloon angioplasty was tried initially with improvement in her symptoms and additionally performed to treat restenosis without any significant adverse events. Her symptoms markedly improved with no recurrence until 8 months after discharge. We also review 10 similar cases reported in the literature. Although further evidence is needed to confirm the usefulness and safety of balloon angioplasty for intracranial GCA, this case report provides valuable information about the endovascular therapy for GCA.
Escape from G1 arrest during acute MEK inhibition drives the acquisition of drug resistance
Authors: Channathodiyil Prasanna , May Kieron , Segonds-Pichon Anne , Smith Paul D , Cook Simon J , Houseley Jonathan 
Published: October 2022

AbstractMutations and gene amplifications that confer drug resistance emerge frequently during chemotherapy, but their mechanism and timing are poorly understood. Here, we investigate BRAFV600E amplification events that underlie resistance to the MEK inhibitor selumetinib (AZD6244/ARRY-142886) in COLO205 cells, a well-characterized model for reproducible emergence of drug resistance, and show that BRAF amplifications acquired de novo are the primary cause of resistance. Selumetinib causes long-term G1 arrest accompanied by reduced expression of DNA replication and repair genes, but cells stochastically re-enter the cell cycle during treatment despite continued repression of pERK1/2. Most DNA replication and repair genes are re-expressed as cells enter S and G2; however, mRNAs encoding a subset of factors important for error-free replication and chromosome segregation, including TIPIN, PLK2 and PLK3, remain at low abundance. This suggests that DNA replication following escape from G1 arrest in drug is more error prone and provides a potential explanation for the DNA damage observed under long-term RAF–MEK–ERK1/2 pathway inhibition. To test the hypothesis that escape from G1 arrest in drug promotes de novo BRAF amplification, we exploited the combination of palbociclib and selumetinib. Combined treatment with selumetinib and a dose of palbociclib sufficient to reinforce G1 arrest in selumetinib-sensitive cells, but not to impair proliferation of resistant cells, delays the emergence of resistant colonies, meaning that escape from G1 arrest is critical in the formation of resistant clones. Our findings demonstrate that acquisition of MEK inhibitor resistance often occurs through de novo gene amplification and can be suppressed by impeding cell cycle entry in drug.
Promoting and Maintaining Changes in Smoking Behavior for Patients Following Discharge from a Smoke-free Mental Health Inpatient Stay: Development of a Complex Intervention Using the Behavior Change Wheel
Authors: Shoesmith Emily , Huddlestone Lisa , Pervin Jodi , Shahab Lion , Coventry Peter , Coleman Tim , Lorencatto Fabiana , Gilbody Simon , Leahy Moira , Horspool Michelle , Paul Claire , Colley Lesley , Hough Simon , Hough Phil , Ratschen Elena 
Published: October 2022

AbstractIntroductionEvidence suggests that smokers can successfully quit, remain abstinent or reduce smoking during a smoke-free mental health inpatient stay, provided behavioral/pharmacological support are offered. However, few evidence-based strategies to prevent the return to prehospital smoking behaviors post-discharge exist.Aims and MethodsWe report the development of an intervention designed to support smoking-related behavior change following discharge from a smoke-free mental health stay. We followed the Behavior Change Wheel (BCW) intervention development process. The target behavior was supporting patients to change their smoking behaviors following discharge from a smoke-free mental health stay. Using systematic reviews, we identified the barriers and enablers, classified according to the Theoretical Domains Framework (TDF). Potential intervention functions to address key influences were identified by consulting the BCW and Behavior Change Technique (BCT) taxonomy. Another systematic review identified effectiveness of BCTs in this context. Stakeholder consultations were conducted to prioritize and refine intervention content.ResultsBarriers and enablers to supporting smoking cessation were identified within the domains of environmental context and resources (lack of staff time); knowledge (ill-informed interactions about smoking); social influences, and intentions (lack of intention to deliver support). Potential strategies to address these influences included goal setting, problem-solving, feedback, social support, and information on health consequences. A strategy for operationalizing these techniques into intervention components was agreed upon: Pre-discharge evaluation sessions, a personalized resource folder, tailored behavioral and text message support post-discharge, and a peer interaction group, delivered by a trained mental health worker.ConclusionsThe intervention includes targeted resources to support smoking-related behavior change in patients following discharge from a smoke-free mental health setting.ImplicationsUsing the BCW and TDF supported a theoretically and empirically informed process to define and develop a tailored intervention that acknowledges barriers and enablers to supporting smoking cessation in mental health settings. The result is a novel complex theory- and evidence-based intervention that will be formally tested in a randomized controlled feasibility study.
Consumption of food away from home in low- and middle-income countries: a systematic scoping review
Authors: Landais Edwige , Miotto-Plessis Mathilda , Bene Chris , Maitre d’Hotel Elodie , Truong Mai Tuyet , Somé Jérome W , Verger Eric O 
Published: October 2022

Abstract

Context
Consumption of food away from home represents an increasing share of people’s food consumption worldwide, although the percentage of food intake that is consumed away from home varies among countries and among individuals. Previous systematic reviews have reported that, overall, consumption away from home negatively affects an individual’s diet and nutritional status. However, these reviews have mainly focused on high-income countries, leaving a gap in knowledge and data for people in low- and middle-income countries (LMICs).

Objective
The present review aimed to describe trends in the consumption of food away from home in an apparently healthy population in low- and middle-income countries (LMICs) and to investigate any associations between this behavior and diet quality, nutritional status, and health outcomes.

Data Sources
A structured search strategy was developed for retrieving (from MEDLINE [via PubMed], Web of Science, and Scopus) peer-reviewed articles published in English from March 2011 until May 2021.

Data Extraction
Forty studies were included, and from them information was obtained based on data from 12 different countries. A qualitative and descriptive approach was used to review the evidence.

Data Analysis
It was found that there was large heterogeneity in the definition of food consumed away from home and the methods used to measure it, making comparisons and syntheses difficult. Consumption of food away from home in LMICs was relatively common and was positively driven by factors such as being a male, being young, having a high socio-economic status, being educated, and living in urban areas. As in high-income countries, consumption of food away from home in LMICs had unfavorable effects on an individual’s diet quality, nutritional status, and health.

Conclusion
There is a need to develop harmonized surveillance systems for better monitoring of the phenomenon of food consumption away from home in LMICs, including a need for a standardized definition for food consumed away from home, to enable the design of effective regulatory policies.
Beyond lockdowns: a systematic review of the impacts of COVID-19 lockdowns on dietary pattern, physical activity, body weight, and food security
Authors: Mekanna Alexandria Nivelle , Panchal Sunil K , Li Li 
Published: October 2022

Abstract

Context
COVID-19 lockdowns may have impacted dietary patterns and nutritional outcomes in many populations.

Objective
The aim of this review was to evaluate the impacts of COVID-19 lockdowns on nutritional patterns, investigating behaviors in the periods before, during, and after lockdowns.

Data Source
This systematic review followed the PRISMA-P methodology. The articles included were identified by searching the key words in Web of Science, PubMed, and Scopus. The key words used in the search included: “COVID19” AND “diet*”, “coronavirus” AND “diet*”, “coronavirus 2” AND “diet*”, “COVID19” AND “nutri*”, “coronavirus” AND “nutri*”, “coronavirus 2” AND “nutri*”, “COVID19” AND “food”.

Data Extraction
Twenty-two original studies were included in this review. Data extraction tables were created for recording author names, year of publication, location of study, duration, lockdown phase, design, methods, aims, number of participants, age, gender, health status, education, socioeconomic status, dietary patterns, food security, physical activity, body weight change or body mass index, and associations with sociodemographic characteristics.

Data Analysis
Impacts of lockdowns on eating patterns, physical activity, body weight or body mass index, and food security were the primary outcomes investigated. Secondary outcomes investigated were associations with sociodemographic characteristics.

Conclusion
COVID-19 lockdowns were associated with significant changes in dietary and lifestyle behaviors of worldwide populations. Impacts were seen during and post-lockdown likely due to more time spent at home, working from home, decreased food availability and accessibility, and augmented stress associated with lockdown.
Can MRI Be Used as a Sole Diagnostic Modality in Determining Clinical Stage in Cervical Cancer?
Authors: Smits Anke , Steins Maud , van Koeverden Sebastiaan , Rundle Stuart , Dekker Heleen , Zusterzeel Petra 
Published: October 2022

Abstract

Objective
The objective of this study was to compare staging by MRI to clinical staging in patients with cervical cancer and to determine the histological accuracy of staging by MRI and examination under anesthesia (EUA) in early stage disease.

Methods
This was a retrospective cohort study of patients diagnosed with cervical cancer between 2010 and 2020 at the Radboud University Medical Centre, the Netherlands. Pretreatment stage (FIGO 2009) by MRI was compared with staging by EUA. Diagnostic accuracy in terms of sensitivity, specificity, positive, and negative predictive value was calculated for MRI and EUA in patients undergoing surgery (early stage disease) with histological results as a reference standard.

Results
A total of 358 patients were included in the study and MRI-based stage differed from EUA stage in 30.7%. In 12.3% this meant a discrepancy in treatment assignment between MRI and EUA. Diagnostic accuracy of MRI in terms of sensitivity and specificity for detecting early stage disease was comparable to EUA in surgical patients. Further analyses showed that premenopausal status, early stage disease and a tumor diameter of &lt;2 cm were associated with improved comparability of MRI and EUA (98%).

Conclusion
There is still a large discrepancy between MRI and EUA. In patients with suspected early stage disease, diagnostic accuracy of MRI is similar to EUA, especially for premenopausal women with early stage disease and a tumor diameter of &lt;2 cm.
The Future of Cultural Diplomacy
Authors: Grincheva Natalia 
Published: October 2022

Abstract
This chapter conceptualizes changes in arts management practices from the perspective of cultural diplomacy, which has experienced significant transformations in the age of increasing digitalization. It explores and illustrates how new media technologies and data practices recalibrate the context in which cultural diplomacy operates by reshaping the medium of artistic communication, empowering new actors and equipping them with new tools to establish, deliver, maintain, and assess their global communication campaigns. The chapter identifies and describes three key aspects of cultural diplomacy transformations: virtualization, algorithmization, and datafication. Exploring the current cultural diplomacy activities reflected through institutional and government reports and press releases, the chapter offers a bird’s-eye view of global arts practices to critically reflect on the new dimension of cultural diplomacy.