bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved extended state observer-based global sliding-mode finite-time control for displacement tracking of a hydraulic roofbolter
Authors: Zhang Zhen , Guo Yinan , Gong Dunwei , Zhu Song 
Published: June 2022

Abstract
The dead-zone nonlinearity and uncertain dynamics inevitably weaken the tracking performance of the displacement system for a hydraulic roofbolter. To address the above problem, this paper proposes a global slidingmode controller based on a reduced-order PD-type extended state observer (GSMC-PDESO). Firstly, the displacement system model of a hydraulic roofbolter is built by using a compensation technique to suppress the effect of dead-zone nonlinearity on control performance. Following that, a novel extended state observer that has less dimensions and few gains than standard one, called reduced-order PD-type extended state observer, is designed, with the purpose of improving the estimation performance and suppressing noise amplification. Moreover, a global sliding mode unit mainly composed of a novel global integral sliding-mode surface (NGISMS) and a novel global sliding-mode control law (NGSMCL) is developed, which aims to improve global robustness, eliminate the chattering and adverse impact on estimation error of disturbances, as well as provide an effective and continuous control law. By comparing the proposed GSMC-PDESO with ten control methods, the comparative experimental results verify the effectiveness of the proposed GSMC-PDESO and strategies.
Tribotronic Control of Ionic Boundary Films
Authors: Reddy Akepati Bhaskar , Pilkington Georgia , Rutland Mark W. , Glavatskih Sergei 
Published: June 2022

Abstract
The effect of electric potential on the lubricating adsorbed ionic films has been studied for a non-halogenated phosphonium orthoborate ionic liquid used as an additive in a biodegradable oil. A tribotronic system, designed around a ball-on-disc film thickness measurement system, was developed and manufactured in-house. This setup allowed for applying an electric potential between the test ball and a set of counter electrodes. The lubricating film thickness clearly decreased at negative potentials and increased at positive potentials. The trends suggested that the anions, acting as anchors on the surface, are instrumental in the formation of thick and robust lubricating ionic boundary films. The application of high positive potential, outside the electrochemical window, resulted in an enormous boost to film thickness, suggesting the formation of ionic multi-layers. The complementary neutron reflectance experiment showed electroresponse in the form of a change in thickness and the ionic composition of the boundary films.
Cross-shelf transport of Barents Sea dense water as a sink for atmospheric CO2 in the Arctic Ocean
Authors: Rogge Andreas , Janout Markus , Zakharova Nadezhda , Trudnowska Emilia , Hoerstmann Cora , Wekerle Claudia , Oziel Laurent , Schourup-Kristensen Vibe , Ruiz-Castillo Eugenio , Schulz Kirstin , Povazhnyy Vasily , Iversen Morten , Waite Anya 
Published: June 2022

Abstract
Export into the deep sea can store significant amounts of atmospheric carbon (C) on millennial time scales, buffering global warming1,2. The Barents Sea is one of the most biologically productive areas of the Arctic Ocean3,4 but C retention times there were thought to be short5. Here we show that dense bottom water formation and transport over the continental slope into the deep sea6–8 result in deep injection of substantial amounts of organic C with long retention times. Observational evidence complemented by numerical model simulations revealed a deep and widespread C injection driven by Barents Sea Bottom Water transport with daily lateral fluxes of ~2.2 kt C d-1 to ~1200 m in the Nansen Basin. With increasing distance from the outflow region, the plume expanded and penetrated into even deeper waters, and towards the sediment (retention time hundreds of millennia). Numerical model and genomic data suggest a seasonally fluctuating but continuous transport of C-rich phytoplankton and resuspended material from the Barents and Kara Sea shelves. This mechanism could sequester ~1/3 of total C burial across the whole Barents Sea9. Our findings combined with those from other export regions of C-rich dense waters in the Arctic10,11 and around Antarctica12–16 highlight the importance of lateral transport of bottom water as a C sink globally. Resolving uncertainties around negative feedbacks of global warming due to sea ice decline will necessitate observation of changes in bottom water formation17 and biological productivity3 at a resolution high enough to quantify future deep C injection.
Self-supervised machine learning pushes the sensitivity limit in label-free detection of single proteins below 10 kDa
Authors: Dahmardeh Mahyar , Dastjerdi Houman Mirzaalian , Mazal Hisham , Köstler Harald , Sandoghdar Vahid 
Published: June 2022

Abstract
Interferometric scattering (iSCAT) microscopy is a label-free optical method capable of detecting single proteins, localizing their binding positions with nanometer precision, and measuring their mass. In the ideal case, iSCAT is limited by shot noise so that collection of more photons should allow its detection sensitivity to biomolecules of arbitrarily low mass. However, a number of technical noise sources combined with speckle-like background fluctuations have restricted the detection limit in iSCAT. Here, we show that an unsupervised machine learning isolation forest algorithm for anomaly detection pushes the mass sensitivity limit by a factor of four to below 10 kDa. We implement this scheme both with a user-defined feature matrix and a self-supervised FastDVDNet and validate our results with correlative fluorescence images recorded in total internal reflection mode. Our work opens the door to the optical detection of small traces of disease markers such as alpha-synuclein, chemokines, and cytokines.
Gut microbiota dysbiosis exaggerates ammonia-induced tracheal injury via TLR4 signaling pathway
Authors: zhou ying , Zhao Xin , zhang minhong , feng jinghai 
Published: June 2022

Abstract
Background: Ammonia is a toxic air pollutant that causes severe respiratory tract injury in animals and humans. Gut microbiota has found to be involved in the development of respiratory tract injury induced by air pollutants, however, the specific mechanism requires investigation. Results: Here, we found that, inhaled ammonia induced tracheal injury by reducing expression of claudin-1, increasing expression of muc5ac, TLR4, MyD88, NF-κB and cytokines (TNF-α, IL-1β, IL-6 and IL-10), and also altering tracheal microbiota composition. Spearman correlation analysis indicated that gut microbiota dysbiosis positively correlated with TLR4 level in the trachea. Antibiotic depletion intestinal microbiota treatment reduced the severity of ammonia-induced tracheal injury via TLR4 signaling pathway. Microbiota transplantation induced the tracheal injury via TLR4 signaling pathway even without the ammonia exposure. Conclusions: These results indicate that gut microbiota dysbiosis exaggerates ammonia-induced tracheal injury via TLR4 signaling pathway. In addition, the [Ruminococcus]_torques_group, Faecalibacterium, unclassified_f_Lachnospiraceae may be the core gut microbiota contributing to the alterations of tracheal microbiota composition.
Morphological and biometrical characterization of otoliths for three populations of the genus Pagellus in the western and eastern in Mediterranean Sea (Tunisia)
Authors: HOUETO M. F. A. , MEJRI M. , TAZARKI M. , BAKKARI W. , FALEH A. BEN , CHALH A. , QUIGANRD J. P. , TRABELSI M. 
Published: June 2022

Abstract
The shape of otoliths of three species of fishes of the genus Pagellus (Pagellus erythrinus, Pagellus acarne and Pagellus bogaraveo) sampled in the marine environment of the western Mediterranean (Kelibia Sea) and the eastern Mediterranean (Bizerte Sea) in Tunisia was studied in order to determine a differentiation by a discriminant factorial analysis and an analysis of biometric measurements. The different results showed an asymmetry within and between the otoliths of the different populations. Despite the difference between Pagellus erythrinus of the Western basin and Pagellus erythrinus of the Eastern basin, the observed intraspecific variation fades in front of the interspecific variation. The Pagellus erythrinus sampled in the basin (Western and Eastern) allowed us to highlight the polymorphism of the otoliths thanks to the highly significant differences obtained (p-value < 0.0001).
Novel biosynthesis of MnO NPs using Mycoendophyte: Industrial bioprocessing strategies, characterization, scaling-up production, and its evaluation as anti-phytopathogenic agents
Authors: EL-Moslamy Shahira H. , Yahia I. S. , Zahran H. Y. , Kamoun Elbadawy A. 
Published: June 2022

Abstract
Objectives: This is the first time in literature to the biosynthesis of rod-shaped myco-synthesized MnO NPs in average diameter ~35nm using extracellular bioactive metabolites of endophytic Trichoderma virens strain EG92 as capping/reducing agents and MnCl2.4H2O as a parent component. Methods: The wheat bran medium was chosen to grow endophytic strain EG92, which produced a variety of bioactive metabolites in extracellular fraction, which increases the yield of MnO NPs to 9.53 g/l. The whole medium and fungal growth conditions that influenced biomass generation were optimized as successive statistical optimization approaches (Plackett-Burman and Box-Behnken designs). Results: The production improvements were achieved at pH 5.5, WBE (35%), and inoculum size (10%), which increased Xmax to twelve-folds (89.63 g/l); thereby, Pmax increased to eight-folds (82.93 g/l). After 162 hours, Xmax (145.63 g/l) and Pmax (99.52 g/l) on the side of µmax and YX/S were determined as 0.084 and 7.65, respectively. Via Taguchi experimental design, fungus-fabricated MnO NPs reaction was improved by adding 0.25M of MnCl2.4H2O to 100% of fungal extract (reducing/capping agents) and adjusting the reaction pH adjusted to ~5. This reaction was incubated at 60°C for 5h before adding 20% fungal extract (stabilizing agent). Also, Pmax was raised 40-fold (395.36g/l) over the BC. Conclusions: Our myco-synthesized MnO NPs exhibit faster and more precise antagonistic actions against phytopathogenic bacteria than fungi; they could be employed as an alternative and promised nano-bio-pesticide to manage a variety of different types of disease-pathogens in the future.
No concerns for post-stroke seizure or epilepsy with rTPA; A retrospective cohort study
Authors: Abbasi Mohammad Hossein , Esmaeili Sara , Tabatabaee Seyedehnarges , Sheibani Fatemeh , Pirouz Mahdi Saberi , Joghataei Mohammad Taghi , Mokhtari Mahisa , Alavi Seyedeh Niloufar Rafiei , Mostafavi Keihan , khotbehsara Samaneh Tanhapour , Siahpoosh Fateme , Soleimani Sevim , Hatam Jaber , Mirzaasgari Zahra 
Published: June 2022

Abstract
Background:
Recombinant tissue plasminogen activator (rTPA) is the gold standard therapy for ischemic stroke patients within the appropriate time interval. In addition to its undoubtedly benefits, recognizing its possible adverse effects is of utmost importance. This study aims to investigate the possible correlation between rTPA administration and the risk of post-stroke epilepsy.
Methods:
In a retrospective cohort study, we enrolled subjects identified to have an ischemic stroke event without prior history of epilepsy based on their medical records. Then, followed them retrospectively regarding any subsequent seizure or epilepsy syndromes.
Results:
rTPA therapy showed no correlations with seizures during the first week after stroke or with the epilepsy syndromes. Positive history of prior ischemic stroke, cortical localization of stroke, cardio embolic source of the stroke, and positive hemorrhagic complication were predictors of post-stroke seizure during the first week following the stroke event. Higher final Modified Rankin Scale (MRS) and cortical localization of stroke were predictors of post-stroke epilepsy (PSE).
Conclusion
rTPA is a safe therapeutic measure for patients with ischemic stroke with no concerns of subsequent development of post-stroke seizure or epilepsy.
Antibacterial activity of carboxymethyl chitosan dialdehyde starch Schiff base and its metal complex
Authors: Ouyang Jinyu , Li Zhenbiao , Miao Jincheng , Wang Yongtao , Hu Langrong , Wang Xiaojuan 
Published: June 2022

Abstract
Carboxymethyl chitosan dialdehyde starch Schiff base (CMCDAS) and its metal complexes were synthesized by corn starch (St), sodium periodate, carboxymethyl chitosan and metal ions (copper, zinc, nickel, silver), and were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermogravimetric analyzer (TGA), energy dispersive spectroscopy (EDS) and X-ray powder diffraction (XRD). The antibacterial activities of CMCDAS against E. coli and S. aureus increased according with its increasing nitrogen content, and the best minimum inhibitory concentrations (MIC) to E. coli and S. aureus were 30 mg/mL, respectively. Furthermore, the minimum inhibitory concentrations (MIC) of the metal Complexes (copper, nickel, silver, and zinc) against S. aureus were 7.50 mg/mL, 30 mg/mL, 30 mg/mL, and 1.88 mg/mL, respectively; and against E. coli were 7.50 mg/mL, 15 mg/mL, 15 mg/mL, and 0.94 mg/mL, respectively.
D-Tagatose protects against oleic acid-induced acute respiratory distress syndrome in rats by activating PTEN/PI3K/AKT pathway
Authors: Huang Jian , Wang Bingjie , Tao Shaoyi , Hu Yuexia , Wang Ning , Zhang Li , Cheng Gao , Zhang Qiaoyun , Wang Chunhui , Chen Chen , Cheng Xingdong 
Published: June 2022

Abstract
Background
Acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar–capillary barrier, resulting in severe alveolar edema and inflammation. D-tagatose (TAG) is a low-calorie fructose isomer with diverse biological activities whose role in ARDS has never been explored. We found that TAG protects lung tissues from injury in the oleic acid-induced rat model of ARDS.
Methods
Seventeen male Sprague–Dawley rats were randomly assigned to 3 groups: Sham (n = 5), ARDS (n = 6), and TAG + ARDS (n = 6). The treatment groups were injected with oleic acid to induce ARDS, and the TAG + ARDS group was given TAG 3 days before the induction. After the treatments, the effect of TAG was evaluated by blood gas analysis and observing the gross and histological structure of the lung.
Results
The results showed that TAG significantly improved the oxygenation function, reduced the respiratory acidosis and the inflammatory response. TAG also improved the vascular permeability in ARDS rats and promoted the differentiation of alveolar type II cells, maintaining the stability of the alveolar structure. This protective effect of TAG on the lung may be achieved by activating the PTEN/PI3K/AKT pathway.
Conclusions
TAG protects against oleic acid-induced ARDS in rats, suggesting a new clinical strategy for treating the condition.
Tuning mechanical, thermal, morphological, barrier, and biodegradation properties of edible pectin-alginate/orange peel biocomposite films
Authors: Uncu Sinan Barış , Mocan Merve 
Published: June 2022

Abstract
Plastic and organic waste pollution create serious consequences on the environment and the welfare of living organisms. More sustainable solutions should be pursued and applied as fast as possible to prevent further worsening of this global problem. The problem of packaging waste, the major part of the plastic pollution, could be solved using biodegradable plastics where mechanical recycling is not possible, such as in case of food-contaminated packages. However, biodegradable plastics made from bio-based materials are typically low in strength, exhibit poor thermal and barrier properties, and are high in cost. In this study, we propose to produce fully biodegradable, edible, pectin-alginate biocomposite films prepared with a food residue, orange peel powder (OPP), which is an abundant and inexpensive natural resource. The mechanical, thermal, and morphological biocomposite films were characterized by using Universal Testing Machine, Differential Scanning Calorimeter, Thermogravimetric Analyzer and Scanning Electron Microscope. Biodegradability was measured by using soil burial method and water vapor permeability test was performed according to the ASTM E96 standard. These properties were tuned by changing the type, amount of the components and the size of OPP in the film formulation in a systematic manner. The biocomposite films containing 2% CaCl2, 0.7 g/g glycerol, and 30% fine OPP as a filler displayed mechanical properties comparable to those of commercially available packaging films while also exhibiting biodegradability and rather high thermal stability. The biocomposite films, prepared only from natural, edible, and vegan materials, offer promising environmentally friendly alternatives to non-biodegradable petroleum-based plastics to produce fully biodegradable packaging films with tuned properties according to food packaging requirements. While the valorization of OPP improved the properties of the biocomposite edible films, it also proposes a sustainable solution to the organic waste problem.
Prevalence of Surgical Site infections among Surgical operated patients in Zewditu Memorial Hospital. Addis Ababa Ethiopia December 2020
Authors: Abdissa Girma , Bekele shiferaw , Abraham Eyakem 
Published: June 2022

Abstract
Background: Surgical site infections are the most common kinds of hospital-acquired infections. It's a common complication that can cause serious morbidity and mortality after surgery. It is also the major cause of extended hospital stays, accounting for up to 20% of hospital expenses. Methods and materials. A random sample of 144 surgical patients was analyzed utilizing a hospital-based retrospective cross-sectional study technique from January 1 to December 31, 2019. The information was acquired using a World Health Organization-developed modified standardized checklist for surgery safety and the national surveillance network for nosocomial infections. A rigorous random sampling strategy was used to choose study participants. Descriptive statistics such as frequency and percentage were used to describe the data. Result:-A total of 13 of the 144 patients who were operated on had surgical site infections (9.02 percent). Elective surgical cases made up 102 (71%) of the total, while emergency surgical cases comprised 42 (29%). Preventive antibiotics were administered to the remaining 99 (69%) research participants, with 73 (73%) receiving ceftriaxone, 3% receiving ampicillin, and 23 (24%) receiving a combination of ceftriaxone and metronidazole. There were 13 cases of surgical site infections in all (9.02 percent). Six (46%) were superficial surgical site infections, four (31%) were deep surgical site infections, and three (23%) were organ space surgical site infections. 11 (84%) patients were treated with IV antibiotics and wound treatment, 1 (8%) cases with wound debridement, and the remaining 1 (8%) cases with laparotomy, antibiotics, and wound management. Conclusion:-In this study area, surgical site infection is infrequent. The bulk of the population is made up of women. The use of prophylactic antibiotics and the age of the patients were both variables in the development of surgical site infections.
Effects of Undaria pinnatifida (Wakame) on postprandial glycaemia: in vitro and in vivo studies
Authors: Mitamura Rieko , Yoshinaga Keiko 
Published: June 2022

Abstract
Brown seaweeds, such as Undaria pinnatifida (wakame), contain sodium alginate, which can affect postprandial blood glucose levels. We previously reported the effects of wakame on postprandial glycaemia in humans; however, the underlying mechanism remains unclear. We aimed to investigate the mechanism underlying the influence of ingested wakame on postprandial blood glucose levels. We conducted in vitro studies to determine the inhibitory activity of wakame on the glucose release rate and in vivo studies to determine the acute effects of wakame on postprandial blood glucose levels. The in vitro study was used to assess low-sodium wakame powder, low-sodium and low-fat wakame powder, soluble and insoluble fractions obtained from dried wakame, and commercially available sodium alginate. Glucose release rate was measured using an in vitro digestion model. The in vivo study was conducted using a crossover method, wherein healthy young adult participants were given 150 g of rice with or without wakame (2 g or 4 g dried wakame). The glucose release rates of all wakame extracts and sodium alginate were significantly lower than that of the control. The soluble fraction significantly inhibited the release of glucose. In the in vivo study, blood glucose levels 15 min after ingestion were significantly lower after consuming rice with 2 g of wakame than when consuming rice alone. Moreover, the ingestion of 4 g of wakame resulted in significantly lower blood glucose levels after meal consumption. These results suggest that the highly viscous soluble fraction of wakame, which contains sodium alginate, increases the viscosity of the gastrointestinal contents and delays glucose absorption. (UMIN000047854)
Analgesic efficacy of suprascapular nerve block versus combined suprascapular and axillary nerve block in patients undergoing shoulder arthroscopy: A prospective, randomized, comparative study
Authors: Ray Subrata , Mitra Anuradha , Sanyal Ramapati , Hussain Tabish , Naz Anjum 
Published: June 2022

Abstract

Background and aim: This study aimed to compare the efficacy of combined suprascapular nerve block (SSNB) and axillary nerve block (ANB) with SSNB alone for analgesia after shoulder arthroscopy in terms of level of pain scores, total analgesic consumption and patient satisfaction in 24 hours. Methods: Forty one patients posted for shoulder arthroscopy were randomly allocated into two groups, group S (n=20), receiving SSNB and group C (n=21) receiving combined SSNB and ANB. Visual analogue scale (VAS) both at rest and during movement at 1, 3, 6, 12, 24 hours and at the time of first demand, total consumption of analgesics in 24 hours and patient satisfaction score at 12 and 24 hours were noted. Results: The VAS scores both at rest and during movement were significantly less in group C at 1, 6, 12 hours and at the time of first demand of analgesic (p < 0.05). Compared to group S, group C had a longer pain free duration (154.3 ± 11.41 min vs 36.60 ± 6.553 min; p < 0.001) and lesser cumulative consumption of pethidine (300.0 ± 8.894 mg vs 336.8 ± 13.27 mg; p = 0.0256). The satisfaction level was better in group C at 12 hours (p = 0.002) but comparable to the group S at 24 hours (p= 0.0673). Conclusion: Combined SSNB and ANB provided better pain relief in first 12 hours, better patient satisfaction in the first 12 hours and decreased overall consumption of analgesics in the first 24 hours compared to SSNB alone.