bluuebunny/crossref_metadata_2025_split huggingface dataset:
The application of full-size three-dimensional individual printed model combined with three-dimensional digital demonstration can facilitate patient’s preoperative comprehension to robotic-assisted laparoscopic partial nephrectomy
Authors: Yuan Xiaobin , Liu Xiaolei , Jing Qiang , Liu Fan , Zhang Xuhui 
Published: June 2022

Abstract
Background
In this study, it was aimed to evaluate the feasibility and effectiveness of full-size three-dimensional individual printed model (3D-IPM) based on computerized tomography (CT) reconstruction combined with 3D individual digital models (3D-IDMs) for improving the patient’s and their families’ comprehension levels of robotic-assisted laparoscopic partial nephrectomy (RALPN) preoperatively.

Methods
Between January 2020 and January 2021, 37 patients underwent RALPN in our institution. 3D individual digital models (3D-IDMs) were reconstructed based on the data of computerized tomography (CT) scanning and full-size 3D-IPMs were fabricated correspondingly. For each patient and his/her closest accompanying immediate family member (CAIFM) (spouse or son/daughter), two semi-structured conversations were held by using CT films (1st conversation) and 3D-IPM combined with 3D-IDM demonstration (2nd one) respectively. The preoperative levels of comprehension were evaluated quantitatively by using a self-made preoperative comprehending score (PCS) in the patients and CAIFMs.

Results
All the fabrications of full-size 3D-IPMs and all the operations were technically successful. The total PCS elevated significantly by presenting 3D-IPM combined with 3D-IDM demonstration compared with CT films (42.5 vs 35.5 in patients, P < 0.001; 42.9 vs 35.8 in CAIFMs, P < 0.001). Sub-PCSs in the evaluating aspects of renal anatomy, mass characteristics, the upcoming RALPN procedure, potential complication risks, and prognosis also showed a uniformed climbing pattern with the assistance of 3D-IPM+3D-IDM.

Conclusion
The application of 3D-IPM presentation combined with 3D-IDM demonstration can improve the preoperative comprehension of patient and CAIFM to RALPN with more direct-viewing and verisimilar presentation, and can be used in RALPN patient education for increasing patients’ and their families’ cognitive empowerment.
TLR4 regulates RORγt+ regulatory T-cell responses and susceptibility to colon inflammation through interaction with Akkermansia muciniphila
Authors: Liu Yaojiang , Yang Min , Tang Li , Wang Fengchao , Huang Shengjie , Liu Shuang , Lei Yuanyuan , Wang Sumin , Xie Zhuo , Wang Wei , Zhao Xiaoyan , Tang Bo , Yang Shiming 
Published: June 2022

Abstract
Background
Well-balanced interactions between gut microbiota and the immune system are essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel diseases (IBD). Toll-like receptor 4 (TLR4) functions as a sensor mediating the crosstalk between the intestinal commensal microbiome and host immunity, but the influence of TLR4 on the shaping of intestinal microbiota and immune responses during colon inflammation remains poorly characterized. We investigated whether the different susceptibilities to colitis between wild-type (WT) and TLR4−/− mice were gut microbiota-dependent and aimed to identify the potential immunity modulation mechanism.

Methods
We performed antibiotic depletion of the microbiota, cohousing experiments, and faecal microbiota transplantation (FMT) in WT and TLR4−/− mice to assess the influence of TLR4 on intestinal microbial ecology. 16S rRNA sequencing was performed to dissect microbial discrepancies, and dysbiosis-associated immune perturbation was investigated by flow cytometry. Akkermansia muciniphila (A. muciniphila)-mediated immune modulation was confirmed through the T-cell transfer colitis model and bone marrow chimaera construction.

Results
TLR4−/− mice experienced enhanced susceptibility to DSS-induced colitis. 16S rRNA sequencing showed notable discrepancy in the gut microbiota between WT and TLR4−/− mice. In particular, A. muciniphila contributed most to distinguishing the two groups. The T-cell transfer colitis model and bone marrow transplantation (BMT) consistently demonstrated that A. muciniphila ameliorated colitis by upregulating RORγt+ Treg cell-mediated immune responses. Mucosal biopsies from human manifested parallel outcomes with colon tissue from WT mice, as evidenced by the positive correlation between TLR4 expression and intestinal A. muciniphila colonization during homeostasis.

Conclusions
Our results demonstrate a novel protective role of TLR4 against intestinal inflammation, wherein it can modulate A. muciniphila-associated immune responses. These findings provide a new perspective on host-commensal symbiosis, which may be beneficial for developing potential therapeutic strategies.

Graphical Abstract
Effects of medications on incidence and risk of knee and hip joint replacement in patients with osteoarthritis: a systematic review and meta-analysis
Authors: Cui Beibei , Chen Yuehong , Tian Yunru , Liu Huan , Huang Yupeng , Yin Geng , Xie Qibing 
Published: June 2022

Abstract
Background
This systematic review and meta-analysis aimed to investigate the incidence and risk of knee and hip replacement in patients with osteoarthritis (OA) treated with different medications.

Methods
OVID MEDLINE, OVID EMBASE, Cochrane and Web of Science electronic databases were searched from inception to May 4th, 2022. Clinical trials, including randomized controlled trials, cohort studies and case–control studies, were selected. The meta-analysis effect size was estimated using either incidence with 95% confidence intervals (CIs) or odds ratio (OR)/relative risk (RR) with 95% CIs. The risk of bias and heterogeneity among studies were assessed and analyzed.

Results
Forty studies were included, involving 6,041,254 participants. The incidence of joint replacement in patients with OA varied according to the study design and treatments. The incidence of knee arthroplasty varied from 0 to 70.88%, while the incidence of hip arthroplasty varied from 11.71 to 96.43%. Compared to non-users, bisphosphonate users had a reduced risk of knee replacement (RR = 0.71, 95% CI: 0.66–0.77; adjusted hazard ratio [aHR] = 0.76, 95% CI: 0.70–0.83). Compared to intra-articular corticosteroid users, hyaluronic acid (HA) users had a higher risk of knee arthroplasty (RR = 1.76, 95% CI: 1.38–2.25). No publication bias was observed.

Conclusions
Bisphosphonate treatment is associated with a reduced risk of knee replacement. More studies are needed to validate our results due to the limited number of eligible studies and high heterogeneity among studies.
An indoor fusion navigation algorithm using HV-derivative dynamic time warping and the chicken particle filter
Authors: Chen Jian , Song Shaojing , Gong Yumei , Zhang Shanxin 
Published: June 2022

AbstractThe use of dead reckoning and fingerprint matching for navigation is a widespread technical method. However, fingerprint mismatching and low fusion accuracy are prevalent issues in indoor navigation systems. This work presents an improved dynamic time warping and a chicken particle filter to handle these two challenges. To generate the Horizontal and Vertical (HV) fingerprint, the pitch and roll are employed instead of the original fingerprint intensity to extract the horizontal and vertical components of the magnetic field fingerprint. Derivative dynamic time warping employs the HV fingerprint in its derivative form, which receives higher-level features because of the consideration of fingerprint shape information. Chicken Swarm Optimization (CSO) is used to enhance particle weights, which minimizes position error to tackle the particle impoverishment problem for a fusion navigation system. The results of the experiments suggest that the enhanced algorithm can improve indoor navigation accuracy significantly.
ICT and agricultural sector performance: empirical evidence from sub-Saharan Africa
Authors: Oyelami Lukman O. , Sofoluwe Nurudeen Afolabi , Ajeigbe Omowumi Monisola 
Published: June 2022

AbstractICT infrastructure is considered crucial to performance and overall development of many sectors in sub-Saharan Africa (SSA). Yet, there exists insufficient evidence on the effect of ICT on agriculture real output and export performance in the African continent. This study investigates the effect of ICT infrastructure on agriculture sector performances in SSA using panel autoregressive distributed lag (ARDL) approach. Panel data were collected over the period of twenty-three (23) years (1995–2017) in 39 SSA countries. Two models were specified using agricultural value addition and agriculture products as a percentage of total merchandise export as dependent variables. Key independent variables include mobile-cellular telephone subscription and individual using the internet. The study also introduced important control variables such as livestock production index and crop production index. The results from the estimation provide substantial evidence to show that ICT infrastructure has positive externality on agricultural sector performances in the long run. However, there is no evidence to maintain this position in the short run. The study, therefore, recommends that there should be a cautious approach to increasing investment in ICT infrastructure. Provision of in ICT infrastructure alone may not automatically improve agricultural output. Thus, there is a need for extension services to propagate and educate farmers on the importance of continuous adoption of ICT infrastructure for agricultural practices in SSA.
H-theorems for systems of coupled nonlinear Fokker-Planck equations
Authors: Plastino A. R. , Wedemann R. S. , Nobre F. D. 
Published: June 2022

Abstract
Nonlinear diffusion and Fokker-Planck equations constitute valuable tools in the study of diverse phenomena in complex systems. Processes described by these equations are closely related to thermostatistical formalisms based on generalized entropic functionals. Inspired by these relations, we explore the behavior of systems of coupled, nonlinear Fokker-Planck equations. In particular, we establish an H-theorem for a wide family of this type of systems. This H-theorem is formulated in terms of an appropriate free-energy–like functional. The nonlinear evolution equations discussed here include, as particular instances, those governing the dynamics of interacting multi-species, many-body systems in the overdamped-motion regime.
Comparison of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis in children at a resource limited setting of South Punjab, Pakistan
Authors: Ahmad Tauseef , Zarafshan Uzma , Sahar Bushra 
Published: June 2022

Objectives: To compare the efficacy of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis (AGE) in children at a resource limited emergency setting of South Punjab, Pakistan.
Methods: This open label randomized controlled trial was conducted at The Pediatric Emergency Department of Tehshil Headquarter Hospital, Liaqatpur, Pakistan, from July 2020 to June 2021. A total of 300 children of both genders aged below 12 years of age having 3 or more non-bilious, non-bloody vomiting episodes within 24 hours and with suggestive signs and symptoms of AGE were enrolled and randomized (150 in each group). Efficacy of both drugs was compared in terms of need of 2nd dose within 15 minutes, cessation of vomiting at 6-hour and 24-hour follow up.
Results: Out of a total of 300 children, 162 (54.0%) were male. Mean age was 4.7±2.3 years. Twenty seven (18.0%) children in Ondansetron group required 2nd dose within 15 minutes while 38 (25.3%) children in Domperidone group required the 2nd dose (p=0.1232). Cessation of vomiting at 6-hour interval was noted among 126 (84.0%) children in Ondansetron group in comparison to 118 (78.7%) in Domperidone group (p=0.2359). It was revealed that 127/142 (89.4%) children in Ondansetron group had cessation of vomiting at 24-hours follow up while this was noted to be among 108/134 (80.6%) children in Domperidone group (p=0.0390).
Conclusion: In comparison to Domperidone, Ondansetron was found to have better efficacy aiming cessation of AGE associated vomiting among children with mild to moderate dehydration.
Clinical Trial Registration: NCT05076461 (www.clinicaltrials.gov).
doi: https://doi.org/10.12669/pjms.38.6.5532
How to cite this:Ahmad T, Zarafshan U, Sahar B. Comparison of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis in children at a resource limited setting of South Punjab, Pakistan. Pak J Med Sci. 2022;38(6):---------. doi: https://doi.org/10.12669/pjms.38.6.5532
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Utility of McGrath Video Laryngoscope in detecting unexpected Tracheal tube kinking
Authors: Mahar Abdullah Nisar , Faraz Shafiq  
Published: June 2022

doi: https://doi.org/10.12669/pjms.38.6.6582
How to cite this:Nisar A, Shafiq F. Utility of McGrath Video Laryngoscope in detecting unexpected Tracheal tube kinking. Pak J Med Sci. 2022;38(6):---------. doi: https://doi.org/10.12669/pjms.38.6.6582
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The effect of ICU diaries on the occurrence of impaired mental health and quality of life of ICU SARS-CoV-2 patients and their families: a protocol for an observational cohort study
Authors: Rutjes-Weurding Laura , Pouwels Sjaak , van Oers Jos , de Haas Mechteld , van Slobbe Christel , Ruitinga Renske , Oomen Margo , Ramnarain Dharmanand 
Published: June 2022

Background: The SARS-CoV-2 pandemic puts patients and their relatives at risk of developing post-intensive care syndrome (PICS and PICS-family). The use of an intensive care unit (ICU) diary for these patients could help fill in memory gaps and complete their fragmented illness narrative. Objectives: The aim of this study is to evaluate the effect of an ICU diary on the occurrence of impaired mental health in patients admitted with a SARS-CoV-2 infection and their relatives. Methods: An observational cohort study of SARS-CoV-2 patients treated in the ICU of Elizabeth-Tweesteden Hospital (ETZ) in Tilburg, The Netherlands will be conducted. Adult patients admitted at the ICU because of respiratory insufficiency due to SARS-CoV-2, who are mechanically ventilated, are included. During treatment in the ICU a diary is kept of the patient. Anxiety, depression and post-traumatic stress disorder, cognitive dysfunction and quality of life will be screened in patients and their relatives by using the psychosocial screening instrument for adult trauma patients (PSIT), the Cognitive Failure Questionnaire (CFQ) and the short-form health survey 36 (SF-36). The recollection of patients’ memory of the ICU stay will be evaluated by the ICU memory tool. The appreciation of the ICU diary will be assessed using a questionnaire. Results: Participants’ characteristics including how they valued the diary, and their memory of ICU treatment will be reported. Multiple logistic regression analysis will be performed for analyzing the relation between mental health outcome and the use of ICU diaries. Change in PICS symptoms over time will be analyzed using longitudinal data analysis. Missing values in questionnaires will be analyzed using missing value analysis and multiple imputations at item level will be performed if necessary. Conclusions: This study will contribute to the knowledge of mental health outcome in SARS-CoV-2 patients and the use of ICU diaries in this group.
IL-2, IL-6 and chitinase 3-like 2 might predict early relapse activity in multiple sclerosis
Authors: Petržalka Marko , Meluzínová Eva , Libertínová Jana , Mojžišová Hana , Hanzalová Jitka , Ročková Petra , Elišák Martin , Kmetonyová Silvia , Šanda Jan , Sobek Ondřej , Marusič Petr 
Published: June 2022

Background
The possibility to better predict the severity of the disease in a patient newly diagnosed with multiple sclerosis would allow the treatment strategy to be personalized and lead to better clinical outcomes. Prognostic biomarkers are highly needed.

Objective
To assess the prognostic value of intrathecal IgM synthesis, cerebrospinal fluid and serum IL-2, IL-6, IL-10, chitinase 3-like 2 and neurofilament heavy chains obtained early after the onset of the disease.

Methods
58 patients after the first manifestation of multiple sclerosis were included. After the initial diagnostic assessment including serum and cerebrospinal fluid biomarkers, all patients initiated therapy with either glatiramer acetate, teriflunomide, or interferon beta. To assess the evolution of the disease, we followed the patients clinically and with MRI for two years.

Results
The IL-2:IL-6 ratio (both in cerebrospinal fluid) <0.48 (p = 0.0028), IL-2 in cerebrospinal fluid ≥1.23pg/ml (p = 0.026), and chitinase 3-like 2 in cerebrospinal fluid ≥7900pg/ml (p = 0.033), as well as baseline EDSS ≥1.5 (p = 0.0481) and age <22 (p = 0.0312), proved to be independent markers associated with shorter relapse free intervals.

Conclusion
The IL-2:IL-6 ratio, IL-2, and chitinase 3-like 2 (all in cerebrospinal fluid) might be of value as prognostic biomarkers in early phases of multiple sclerosis.
O DIREITO AO ABASTECIMENTO NACIONAL E A DISTRIBUIÇÃO DE COMBUSTÍVEIS
Authors: Tavares André 
Published: June 2022

Contextualização: O artigo assume a premissa de que a rede nacional de distribuição e abastecimento de combustíveis é essencial ao modelo de política econômica e de desenvolvimento brasileiro.
Objetivo: Dessa forma, o texto busca estabelecer os parâmetros constitucionais do direito fundamental ao abastecimento nacional.
Metodologia: Para tanto, utiliza-se da metodologia de revisão bibliográﬁca, contextualizada ao desenvolvimento, na acepção adotada pela Constituição de 1988, e analisa o ordenamento vigente sobre distribuição de combustíveis derivados de petróleo e biocombustíveis no país, como base de concretização do direito ao abastecimento nacional.
Resultado: Infere-se, da pesquisa realizada, que a Constituição brasileira de 1988 reconhece expressamente o desenvolvimento nacional como um objetivo fundamental da República Federativa (art. 3º) que se harmoniza com a disciplina da Ordem Econômica brasileira (art. 170), na qual se identiﬁ ca, de forma implícita, o direito fundamental ao abastecimento.
Eksplorasi Etnomatematika pada Permainan Tradisional Layangan (Pemahaman Materi Bangun Datar Layang-Layang dan Pengembangan Karakter)
Authors: Kuswidi Iwan , Lestari Devinta Fajar , Arfinanti Nurul , Azka Raekha 
Published: June 2022

Etnomatematika dapat menciptakan pembelajaran yang lebih bermakna dan menarik bagi perserta didik. Selain itu, dapat menumbuhkan rasa cinta terhadap budaya lokal. Penelitian ini bertujuan untuk mengeksplorasi etnomatematika dan mengkaji lebih mendalam tentang konsep matematika pada permainan tradisional layangan, menggunakan metode penelitian kualitatif dengan pendekatan etnografi. Hasil analisis dan pembahasan, menunjukkan bahawa terdapat etnomatematika pada permainan tradisional layangan. Pada bagian kerangka layangan terdapat konsep dasar matematika seperti garis, panjang diagonal, titik sudut, dan sudut. Berdasarkan pengamatan bentuk layangan dapat diperoleh rumus keliling dan luas layang-layang melalui pendekatan dua segitiga kongruen dan dua segitiga sama kaki pada bangun layang-layang. Selain terdapat unsur matematika, permainan tradisional layangan memiliki peran dalam penanaman karakter bagi peserta didik. Sehingga dapat disimpulkan bahwa layangan dapat digunakan sebagai media dalam pembelajaran matematika.
Short‐term arm immobilization modulates excitability of inhibitory circuits within, and between, primary motor cortices
Authors: King Erin M. , Edwards Lauren L. , Borich Michael R. 
Published: June 2022

AbstractPrevious research has suggested that short‐term immobilization of the arm may be a low‐cost, non‐invasive strategy to enhance the capacity for long‐term potentiation (LTP)‐like plasticity in primary motor cortex (M1). Short‐term immobilization reduces corticospinal excitability (CSE) in the contralateral M1, and interhemispheric inhibition (IHI) from ipsi‐ onto contralateral M1 is increased. However, it is unclear whether reduced CSE and increased IHI are associated with changes in intracortical inhibition, which has been shown to be important for regulating neuroplasticity in M1. The current study used transcranial magnetic stimulation to evaluate the effects of short‐term (6 h) arm immobilization on CSE, IHI, and intracortical inhibition measured bilaterally in 43 neurotypical young adults (23 immobilized). We replicated previous findings demonstrating that immobilization decreased CSE in, and increased IHI onto, the immobilized hemisphere, but a significant change in intracortical inhibition was not observed at the group level. Across individuals, decreased CSE was associated with a decreased short‐interval intracortical inhibition, an index of GABAA‐ergic inhibition, within the immobilized hemisphere only in the immobilization group. Previous research has demonstrated that decreases in GABAA‐ergic inhibition are necessary for the induction of LTP‐like plasticity in M1; therefore, decreased intracortical inhibition after short‐term arm immobilization may provide a novel mechanism to enhance the capacity for LTP‐like plasticity within M1 and may be a potential target for strategies to augment plasticity capacity to enhance motor learning in health and disease.
Sports activities at a young age decrease hypertension risk—The J‐Fit+ study
Authors: Kumagai Hiroshi , Miyamoto‐Mikami Eri , Someya Yuki , Kidokoro Tetsuhiro , Miller Brendan , Kumagai Michi Emma , Yoshioka Masaki , Choi Youngju , Tagawa Kaname , Maeda Seiji , Kohmura Yoshimitsu , Suzuki Koya , Machida Shuichi , Naito Hisashi , Fuku Noriyuki 
Published: June 2022

AbstractThis study aimed to assess (1) blood pressure between young, current athletes, and non‐athletes early in life; (2) hypertension prevalence between former athletes and the general population later in life; and (3) understand the mechanisms between exercise training and hypertension risks in the form of DNA methylation. Study 1: A total of 354 young male participants, including current athletes, underwent blood pressure assessment. Study 2: The prevalence of hypertension in 1269 male former athletes was compared with that in the Japanese general population. Current and former athletes were divided into three groups: endurance‐, mixed‐, and sprint/power‐group. Study 3: We analyzed the effect of aerobic‐ or resistance‐training on DNA methylation patterns using publicly available datasets to explore the possible underlying mechanisms. In young, current athletes, the mixed‐ and sprint/power‐group exhibited higher systolic blood pressure, and all groups exhibited higher pulse pressure than non‐athletes. In contrast, the prevalence of hypertension in former athletes was significantly lower in all groups than in the general population. Compared to endurance‐group (reference), adjusted‐hazard ratios for the incidence of hypertension among mixed‐ and sprint/power‐group were 1.24 (0.87–1.84) and 1.50 (1.04–2.23), respectively. Moreover, aerobic‐ and resistance‐training commonly modified over 3000 DNA methylation sites in skeletal muscle, and these were suggested to be associated with cardiovascular function‐related pathways. These findings suggest that the high blood pressure induced by exercise training at a young age does not influence the development of future hypertension. Furthermore, previous exercise training experiences at a young age could decrease the risk of future hypertension.