bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Japanese Catheter Ablation Registry (J‐AB): Annual report in 2020
Authors: Kusano Kengo , Yamane Teiichi , Inoue Koichi , Takegami Misa , Nakao Yoko M. , Nakai Michikazu , Kanaoka Koshiro , Tonegawa‐Kuji Reina , Miyamoto Koji , Iwasaki Yu‐ki , Takatsuki Seiji , Nakamura Kohki , Iwanaga Yoshitaka , Shimizu Wataru ,   J‐AB registry investigators
Published: August 2022

AbstractThe Japanese Catheter Ablation (J‐AB) registry, started in August 2017, is a voluntary, nationwide, multicenter, prospective, observational registry, performed by the Japanese Heart Rhythm Society (JHRS) in collaboration with the National Cerebral and Cardiovascular Center using a Research Electronic Data Capture system. The purpose of this registry is to collect the details of target arrhythmias, the ablation procedures, including the type of target arrhythmias, outcomes, and acute complications in real‐world settings. During the year 2020, we have collected a total of 84 591 procedures (mean age of 65.8 years and 66.6% male) from 466 participant hospitals. Detailed data were shown in Figures and Tables.
Conformity of prescription medication labels with label format and content recommendations
Authors: Oh Yeow Boon , Suppiah Sumithra Devi , Chia Deborah Miao‐Hui , Tan Yi Wen , Malhotra Rahul 
Published: August 2022

AbstractBackgroundPrescription medication labels (PMLs) are central in guiding patients to use their medications appropriately. For PMLs to achieve this purpose, their content must enable medication use as desired and be presented in a clear and legible manner.AimThis study assesses the extent to which the format and content of PMLs used in Singapore meet national and/or international recommendations, and if the extent varies across public and private healthcare institutions.MethodThe format and content variables of 113 PMLs were compared against published recommendations. Variability in the extent to which the format and content of PMLs met the recommendations across public and private institutions was assessed through the Chi‐square test or Fisher's exact test.ResultsLess than 50% of the PMLs conformed with the format recommendations of printing instructions in sentence case (35.4%), and the content recommendations for providing drug–food administration instructions (45.3%), using specific dosing intervals for dosing instructions (21.2%), providing an expiry date (17.7%), and generating bilingual labels (5.3%). A higher proportion of private institution PMLs followed the format recommendations of printing instructions in sentence case (p = 0.004) and numeric characters for quantitative values (p = 0.003), and the content recommendations for providing drug indication (p < 0.001). In contrast, a higher proportion of public institution PMLs followed the content recommendations of using specific dosing intervals (p = 0.001), providing side effects/precautions (p = 0.003), and providing drug‐food administration instructions (p = 0.021).ConclusionThere is definite scope for improving the format and content of PMLs in Singapore. Future studies could explore the possible logistical, financial, and administrative reasons that contribute to PML variability across healthcare institutions.
Antioxidant and antimicrobial activities of plants grown in the Mediterranean region
Authors: Kaçar Diren , Bayraktar Oguz , Erdem Cansu , Alamri Abdulhakeem S. , Galanakis Charis M. 
Published: August 2022

AbstractBackgroundThe main objective of this research was to identify plant species with possible bioactivities based on their total phenol content, antioxidant, and antimicrobial properties. Therefore, different parts of 42 plant species grown in the Mediterranean region were extracted with aqueous ethanol solutions to prepare extracts with antioxidant and antimicrobial activities, mainly resulting from their total phenol contents. No detailed laboratory data on the flora of this area exists regarding their total phenol contents and total antioxidant activities.ResultsYields of extraction for each plant material were determined. Extracts were characterized based on their total phenol contents, total antioxidant (both hydrophilic and lipophilic), and antimicrobial activities using Folin–Ciocalteu, Photochemiluminescence, disc diffusion, and microdilution methods, respectively. The extract of Hypericum empetrifolium had the relatively highest total water‐soluble and lipid‐soluble antioxidant activities. Sarcopoterium spinosum extract had relatively high total phenol content. Preliminary screening study was conducted with the disc diffusion method to evaluate the extracts' antimicrobial activities. 26 out of 42 plant species showed significant antimicrobial activities against the growth of microorganisms. Microdilution assays were performed to evaluate the most active plant species with their minimum inhibition concentrations. H. empetrifolium, Pistacia terebinthus, Arbutus unedo, and Cistus parviflorus were the most antimicrobial plant species among those investigated.CONCLUSIONThe new potential sources for the isolation of bioactive natural compounds from specific plant species could be possible with the help of this present screening study. Isolated bioactive natural compounds can be utilized as raw materials in cosmetics, nutraceuticals, food supplements, and pharmaceutical industries.
Real‐life self‐assessment of pruritus relief with a combination of calcipotriol/betamethasone dipropionate foam in patients with plaque psoriasis
Authors: Misery Laurent , Gonnet Jessica , Mackenzie Nadine , Beneton Nathalie , Halioua Bruno 
Published: August 2022

AbstractObjectivesPsoriasis‐related pruritus is a frequent and underestimated symptom with a strong impact on quality of life, psychological condition and sleep. Our main objective was to document, in real‐life clinical practice, the perception of pruritus and the efficacy of a 4‐week topical treatment with a fixed‐dose combination of calcipotriol/betamethasone dipropionate (Cal/BD) foam on psoriasis‐related moderate‐to‐severe pruritus.MethodsThis was an exploratory prospective observational study in psoriasis patients with a pruritus visual analogic scale (VAS) score ≥ 3/10 cm. The primary endpoint was the proportion of responder patients defined as the self‐assessed improvement from baseline of pruritus of at least 2 VAS score points 48 h after the first topical administration. The quality of sleep was assessed on VAS and the quality of life was assessed using the Dermatology Life Quality Index (DLQI) on Day 28.ResultsA total of 81 patients were included by 34 dermatologists and 40 self‐questionnaires were evaluable for efficacy on Day 28. At inclusion, pruritus was self‐assessed as severe by 60.8% of patients, whereas physicians reported severe pruritus in 16.9% of patients. A proportion of 91.4% (95% confidence interval: 82–100) of patients were responders to pruritus relief 48 h after the first Cal/BD application. Relevant improvements in quality of sleep after 24 h (+2.9 ± 3.0) and in quality of life after 28 days (−9.0 ± 6.8) were reported.ConclusionThis exploratory study provides further evidence that pruritus is an underestimated symptom, and it confirms the usefulness of the fixed‐dose combination of Cal/DB foam in relieving moderate‐to‐severe pruritus and improving the quality of life and sleep in patients with plaque psoriasis.
Does human papillomavirus modify the risk of oropharyngeal cancer related to smoking and alcohol drinking? A systematic review and meta‐analysis
Authors: Arif Rawan T. , Mogaddam Meaad A. , Merdad Leena A. , Farsi Nada J. 
Published: August 2022

AbstractObjectiveTo synthesize evidence for interactions of traditional oropharyngeal squamous cell carcinoma (OPSCC) risk factors—tobacco smoking and alcohol drinking—with human papillomavirus (HPV).Data SourcesMEDLINE, Embase, Cochrane Database of Systematic Reviews, ProQuest, and Global Health were searched with no restrictions on language or publication date.MethodsAll case–control studies assessing interactions between these factors in OPSCC were considered. Quality was assessed using the Newcastle‐Ottawa Scale for case–control studies. The main outcome was the OR for developing OPSCC for the following interactions: (1) HPV and smoking, (2) HPV and alcohol drinking, and (3) HPV, alcohol drinking, and smoking. Interactions were assessed from stratified analysis (by HPV status) and/or joint effect analysis (synergy index and multiplicative index).ResultsThe search provided 3084 relevant studies, of which 9 were included. In the stratified analysis, the OR of developing OPSCC among smokers with HPV was less than that among smokers without HPV. A similar pattern was observed for alcohol drinking. This effect persisted among smokers and heavy alcohol drinkers with HPV compared with those without HPV. Joint effect analysis on the additive scale showed sub‐additive antagonistic interactions between HPV and smoking, and between HPV and alcohol. On the multiplicative scale, sub‐multiplicative interactions were found between HPV and smoking, and HPV and alcohol.ConclusionsThis meta‐analysis suggests a negative directed interaction of HPV and smoking; and HPV and heavy alcohol drinking in the development of primary OPSCC on stratified analysis and joint effect analysis.Level of Evidence3A.
Surgical ergonomics: Assessment of surgeon posture and impact of training device during otolaryngology procedures
Authors: Leung Karen L. , Segal Rachel M. , Bernstein Jeffrey D. , Orosco Ryan K. , Reid Chris M. 
Published: August 2022

AbstractObjectiveTo identify factors associated with cervical‐thoracic spine posture in otolaryngology surgeries and evaluate the efficacy of a commercially available posture‐training device in enhancing surgeon ergonomics.MethodsOver 3 months, neck and spine posture from individuals performing otolaryngology surgeries was recorded using UpRight Go 2™. Average baseline posture was first recorded and biofeedback was later introduced to attempt to correct posture. The proportion of time spent in upright/neutral cervical‐thoracic spine posture was correlated with surgeon and procedure characteristics and compared to proportion of upright posture time after biofeedback intervention.ResultsThe proportion of upright operating time was significantly different between procedure subtypes and surgical approaches with best performance in rhinology procedures and worst performance in head and neck surgeries (90% vs. 62%; both p < .001). Female gender, shorter stature, and use of sitting stools were associated with greater proportion of surgery spent upright (all p < .05). Loupes use was associated with less time in upright posture (p < .001). With biofeedback intervention, 8 of 10 subjects demonstrated an average of 5% improvement in operating upright, with most improvement found when performing laryngology procedures (7%) and least improvement in head and neck procedures (2%).ConclusionsWhile surgeon posture varies across otolaryngology surgeries, sitting and minimizing the use of loupes may help promote a more ergonomic operating environment and improve surgeon posture. Although the efficacy of biofeedback intervention from a commercially available posture‐training device differs among otolaryngologists, exploration of alternative interventions and incorporation of an ergonomics curriculum is warranted to address postural issues experienced by many surgeons.Level of Evidence3.
Increased microbial and substrate complexity result in higher molecular diversity of the dissolved organic matter pool
Authors: Chen Qi , Lønborg Christian , Chen Feng , Gonsior Michael , Li Yunyun , Cai Ruanhong , He Chen , Chen Jiaxin , Wang Yu , Shi Quan , Jiao Nianzhi , Zheng Qiang 
Published: August 2022

AbstractMarine dissolved organic matter (DOM) represents one of the largest reduced carbon pools on Earth. Diverse microbial metabolic activities play important roles in shaping this pool. However, the links between changing DOM substrates and microbial communities and its influence on the microbial produced DOM remain poorly understood. In this study, we investigated how the addition of substrates with different complexity (glucose, laminarin, and Synechococcus‐derived DOM) impacted the production of new DOM by an individual opportunist Alteromonas strain and a coastal natural microbial community. Our experiments reveal that the microbial complexity was more important than the substrate in shaping the molecular composition of DOM. Furthermore, our results showed that the DOM composition played a larger role in shaping the microbial compositions than the concentrations of DOM and inorganic nutrients. Combined our network analysis revealed that complex substrates resulted in higher molecular diversity of the microbial produced DOM, sustained a higher microbial diversity, and maintained a more diverse association between microbial communities and DOM molecules. Overall, the present study indicate that the microbial diversity contributes to DOM molecular diversity and vice versa, highlighting the importance of microbial–substrate interactions in shaping the marine DOM pool.
High‐Fidelity Far‐Field Microscopy at λ/8 Resolution
Authors: Xu Ning , Liu Guoxuan , Tan Qiaofeng 
Published: August 2022

AbstractThe emergence of far‐field super‐resolution microscopy has rejuvenated the possibility for nanoscale imaging. Approaches to far‐field super‐resolution that utilize point scanning often depend on spatially reducing the size of the focused spot. However, the focused spot always achieves high resolution at the expense of extremely low light efficiency for the probing mainlobe and high‐intensity sidelobes, which limits the applications in nanoscale imaging and might cause misinterpretation of samples. Here, a sharp probing spot is reported with the diffraction efficiency of 3.76% at the resolution of 38% of the Airy spot size assisted by the 2D multilevel diffractive optical element (DOE) experimentally. The diffraction efficiency of DOE is improved by at least two orders of magnitude at the same resolution by breaking the limitation of circular 0–π binary structure superoscillatory lens. To eliminate the influence of the high‐intensity sidelobes, high‐fidelity images are reconstructed based on the modified deconvolution algorithm by virtue of the prior knowledge. Finally, high‐fidelity far‐field microscopy (HiFi‐FM) is constructed and experimental results show that HiFi‐FM allows the resolution of spatially complex samples better than 69 nm while acquiring high fidelity.
Polymer‐Wrapped Perovskite Single Crystal for Surface Passivation and Robust Stability
Authors: Zhu Yongqi , Liu Yuxue , Jin Bowen , Shi Yang , Wu Zixin , Cao Jinguo , Li Haijin , Wu Congcong 
Published: August 2022

AbstractMetal halide perovskites (MHPs) emerging as a promising semiconducting material have shown superiority in optoelectronic applications. Currently, polycrystalline perovskite thin films are dominantly employed; while owing to the existence of grain boundary, the polycrystalline films typically have charge transport issues. To overcome these limitations, a perovskite single crystal (SC) is synthesized and applied owing to the more superior bulk charge transport properties compared with its polycrystalline counterpart. Nevertheless, due to the defective nature of the crystal surface, the surfaces of single crystals remain the bottleneck that not only induces stability issues but also causes interfacial charge carrier recombination. In this work, triple cation perovskite single crystals, FA0.8MA0.15Cs0.05PbI3 (denoted as FAMACs) are synthesized, and a facile surface modification strategy is reported for single crystals by polymer monolayer coupling, which shows high effectiveness for improving stability and reducing surface trap state density for single crystals. The polymer‐wrapped single crystals exhibit robust stability and a well‐passivated surface, which shows an order of magnitude lower trap density compared with those of unmodified single crystals and achieves a high responsivity of 5.069 A W−1 when used in photodetector applications.
Competition between Heterogeneous Nucleation and Flow‐Induced Crystallization of Polyamide 66 and Its Carbon Nanotube Composites
Authors: Gohn Anne M. , Zhang Xiaoshi , McHale Alexander , Androsch René , Rhoades Alicyn M. 
Published: August 2022

AbstractBoth heterogeneous nucleation and flow‐induced entropy reduction are the two well‐known factors that accelerate polymer crystallization. However, the interplay of nucleation and flow‐induced acceleration is still poorly understood. This work investigates the nucleating effect of carbon nanotubes (CNT) on both the quiescent and flow‐induced crystallization kinetics of polyamide 66 (PA 66). The quiescent crystallization study indicates that CNT acts as a powerful nucleant, as suggested by the fact that the critical cooling rate to bypass crystallization and create the amorphous glassy state changes from 1000 K s−1 in PA 66 neat resin to a rate faster than 4000 K s−1 in the PA 66 nanocomposites. The flow‐induced crystallization study indicates PA 66 onset crystallization time and morphology depend on the shear work introduced by rotational rheometry. A combined acceleration effect from CNT nucleants and flow‐induced crystallization (FIC) persists when the CNT loading is under the saturation limit. However, if CNT loading meets the saturation limit, specific shear work shows no impact on the crystallization time, providing evidence that the role of the FIC acceleration effect no longer exists when nucleant acceleration dominates the crystallization of PA 66.
A Biocompatible 4D Printing Shape Memory Polymer as Emerging Strategy for Fabrication of Deployable Medical Devices
Authors: He Wenyang , Zhou Dong , Gu Hao , Qu Ruisheng , Cui Chaoqiang , Zhou Yanyi , Wang Yu , Zhang Xinrui , Wang Qihua , Wang Tingmei , Zhang Yaoming 
Published: August 2022

AbstractThe rapid development of 4D printing provides a potential strategy for the fabrication of deployable medical devices (DMD). The minimally invasive surgery to implant the DMD into the body is critical, 4D printing DMD allows the well‐defined device to be implanted with a high‐compacted shape and transformed into their designed shape to meet the requirement. Herein, a 4D printing tissue engineering material is developed with excellent biocompatibility and shape memory effect based on the photocrosslinked polycaprolactone (PCL). The fast thiol‐acrylate click reaction is applied for photocrosslinking of the acrylates capped star polymer (s‐PCL‐MA) with poly‐thiols, that enable the 3D printing for the DMD fabrication. The cell viability, erythrocyte hemolysis, and platelet adhesion results indicate the excellent biocompatibility of the 4D printing polymer, especially the biological subcutaneous implantation results confirm the promote tissue growth and good histocompatibility. A 4D printing stent with deformable shape and recovery at a temperature close to human body temperature demonstrated the potential application as DMD. In addition, the everolimus is loaded to the polymer (ps1‐PCL) through host‐guest coordination with β‐cyclodextrin as the core of the star polymer, which shows sustained drug release and improved body's inflammatory response.
Differences in Sex‐Specific Frequency of Glucocerebrosidase Variant Carriers and Familial Parkinsonism
Authors: Ortega Roberto A. , Bressman Susan B. , Raymond Deborah , Ozelius Laurie J. , Katsnelson Viktoriya , Leaver Katherine , Swan Matthew C. , Shanker Vicki , Miravite Joan , Wang Cuiling , Bennett Steffany A.L. , Saunders‐Pullman Rachel 
Published: August 2022

AbstractBackgroundAlthough men and women with the LRRK2 G2019S variant appear to be equally likely to have Parkinson's disease (PD), the sex‐distribution among glucocerebrosidase (GBA) variant carriers with PD, including limited to specific variant severities of GBA, is not well understood. Further, the sex‐specific genetic contribution to PD without a known genetic variant is controversial.ObjectivesTo better understand sex differences in genetic contribution to PD, especially sex‐specific frequencies among GBA variant carriers with PD (GBA PD) and LRRK2‐G2019S variant carriers with PD (LRRK2 PD).MethodsWe assess differences in the sex‐specific frequency in GBA PD, including in subsets of GBA variant severity, LRRK2 PD, and idiopathic PD in an Ashkenazi Jewish cohort with PD. Further, we expand prior work evaluating differences in family history of parkinsonism.ResultsBoth idiopathic PD (267/420 men, 63.6%) (P < 0.001) and GBA PD overall (64/107, 59.8%) (P = 0.042) were more likely to be men, whereas no difference was seen in LRRK2 PD (50/99, 50.5%) and LRRK2/GBA PD (5/10, 50%). However, among GBA PD probands, severe variant carriers were more likely to be women (15/19 women, 79.0%) (P = 0.005), whereas mild variant carriers (44/70 men, 62.9%) (P = 0.039) and risk‐variant carriers (15/17 men, 88.2%) (P = 0.001) were more likely to be men.ConclusionsOur study demonstrates that the male‐sex predominance present in GBA PD overall was not consistent across GBA variant severities, and a female‐sex predominance was present among severe GBA variant carriers. Therefore, research and trial designs for PD should consider sex‐specific differences, including across GBA variant severities. © 2022 International Parkinson and Movement Disorder Society.
Design of monopulse antenna loaded with Fabry–Perot cavity
Authors: Lu Kuo , Kou Na , Yu Shixing , Ding Zhao , Zhang Zhengping 
Published: August 2022

AbstractA monopulse antenna loaded with Fabry–Perot resonator (FPRC) of X‐band for the application of monopulse radars is designed, fabricated, and measured in this letter. The proposed antenna is composed of an FPRC, a feed source that integrates aperture‐coupled microstrip antennas with a sum–difference comparator. The simulation and measurement have demonstrated that the aperture efficiency of the antenna reaches 46%, and the measured gain of the sum beam is 14.8 dBi which is 4.4 dBi higher than the monopulse antenna without an FPRC. The null depth of the difference beam is under −20 dB. The proposed monopulse antenna is of low‐profile, low cost, and simple structure, which can be applied in radar and wireless communication systems.
Design of negative refractive index 3D metamaterial split ring resonator for IoT applications
Authors: Khouser G. Husna , Choukiker Yogesh K. 
Published: August 2022

AbstractThis article presents the unique 3D metamaterial split ring resonator (3D‐MTM SRR) with a high negative refractive index at 2.45 GHz frequency. It is integrated with two layers: one square bracket structure printed on the backside of the substrate and another dual split ring with an air gap placed above the substrate. Both structures are coupled with metallic vias, which serve as connecting vias to create the 3D‐MTM SRR. Simulation and experiment results show good agreement for a high negative refractive index and the effective medium ratio of −30 and 6.16, respectively. To fully comprehend the resonance phenomena of the proposed 3D‐MTM, an analogous circuit analysis is carried out. Thus, the unique properties of 3D‐MTM SRR allow development of the high‐performance radio frequency devices for IoT applications.