bluuebunny/crossref_metadata_2025_split huggingface dataset:
Procedural Characteristics of Intravascular Ultrasound–Guided Percutaneous Coronary Intervention and Their Clinical Implications
Authors: Lee Seung‐Yul , Zhang Jun‐Jie , Mintz Gary S. , Hong Sung‐Jin , Ahn Chul‐Min , Kim Jung‐Sun , Kim Byeong‐Keuk , Ko Young‐Guk , Choi Donghoon , Jang Yangsoo , Kan Jing , Pan Tao , Gao Xiaofei , Ge Zhen , Chen Shao‐Liang , Hong Myeong‐Ki 
Published: July 2022

Background
Despite the clinical benefits to intravascular ultrasound (IVUS) guidance for percutaneous coronary intervention (PCI), most patients with coronary artery disease undergo angiography‐guided PCI alone in the real‐world setting. We sought to investigate the procedural characteristics of IVUS‐guided PCI and their clinical outcomes, as compared with angiography‐guided PCI.

Methods and Results

This was a cohort study using patient‐level data from the IVUS‐XPL (Impact of Intravascular Ultrasound Guidance on the Outcomes of Xience Prime Stents in Long Lesions) and ULTIMATE (Intravascular Ultrasound Guided Drug Eluting Stents Implantation in All‐Comers Coronary Lesions) clinical trials. A total of 2848 patients with 3872 native coronary lesions were included and procedural characteristics assessed by quantitative coronary angiography (QCA) were compared between IVUS and angiography guidance. Stent‐to‐reference vessel diameter ratio (ie, QCA stent sizing) was greater (1.11±0.16 versus 1.07±0.14,
P
<0.001) and high‐pressure postdilation was more frequently performed (83.7% versus 75.4%,
P
<0.001) with IVUS guidance, whereas residual stent edge dissections were more frequent in lesions treated with IVUS guidance (4.6% versus 0.7%,
P
<0.001). Given the dissection risk, optimal QCA stent sizing for IVUS guidance was a stent‐to‐QCA reference vessel diameter ratio ≥1.1 to <1.3. Among 1424 patients (1969 lesions) treated with angiography guidance, QCA stent sizing <1.0 was observed in 651 (33.1%) lesions, while QCA stent sizing ≥1.1 to <1.3 was observed in only 526 (26.7%) lesions. Under angiography guidance, patients with both QCA stent sizing ≥1.1 to <1.3 and high‐pressure postdilation (235 of 1424, 16.5%) had a lower risk of 3‐year target lesion failure compared with others (hazard ratio, 0.532; 95% CI, 0.293–0.966 [
P
=0.038]).

Conclusions
IVUS‐guided PCI resulted in larger QCA‐assessed stent sizing and more frequent postdilation with high‐pressure inflations. These procedures may further improve long‐term clinical outcomes in patients undergoing PCI without IVUS.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01308281 (IVUS‐XPL); NCT02215915 (ULTIMATE).
Atrial Fibrillation and the Risk of Early‐Onset Dementia: A Systematic Review and Meta‐Analysis
Authors: Giannone Maria Edvige , Filippini Tommaso , Whelton Paul K. , Chiari Annalisa , Vitolo Marco , Boriani Giuseppe , Vinceti Marco 
Published: July 2022

Background
Recent studies have identified an increased risk of dementia in patients with atrial fibrillation (AF). However, both AF and dementia usually manifest late in life. Few studies have investigated this association in adults with early‐onset dementia. The aim of this study was to investigate the relationship between AF and early‐onset dementia.

Methods and Results
We searched the PubMed/MEDLINE, Embase, and Scopus databases through April 15, 2022, for studies reporting on the association between AF and dementia in adults aged <70 years, without language restrictions. Two reviewers independently performed the study selection, assessed the risk of bias, and extracted the study data. We performed a meta‐analysis of early‐onset dementia risk according to occurrence of AF using a random‐effects model. We retrieved and screened 1006 potentially eligible studies. We examined the full text of 33 studies and selected the 6 studies that met our inclusion criteria. The pooled analysis of their results showed an increased risk of developing dementia in individuals with AF, with a summary relative risk of 1.50 (95% CI, 1.00–2.26) in patients aged <70 years, and 1.06 (95% CI, 0.55–2.06) in those aged <65 years.

Conclusions
In this systematic review and meta‐analysis, AF was a risk factor for dementia in adults aged <70 years, with an indication of a slight and statistically imprecise excess risk already at ages <65 years. Further research is needed to assess which characteristics of the arrhythmia and which mechanisms play a role in this relationship.
Operative Rib Fixation at a Rural Trauma Center
Authors: Feyh Andrew , Kocher Tim , Smith Dylan , Amiri Farzad , Denning David 
Published: July 2022

Introduction Operative rib fixation is becoming more common in the management of rib fractures, with studies showing benefits of surgery in decreasing time on mechanical ventilation, ICU and total hospital length of stay, and mortality. This paper will review the data from our institution to determine if these benefits were seen in our trauma population. Methods A retrospective review of the institution’s trauma database was conducted, including operative patients (n = 36), control patients (nonoperative patients from October 2018 to October 2019, n = 207), and selected control patients based on similar injury severity score range as operative patients (n = 181). Data reviewed included time on mechanical ventilation, ICU and total hospital length of stay, and disposition at discharge, including mortalities. Operative complications were also reviewed. Results The operative group had a higher ISS compared to both controls, longer average time on mechanical ventilation, longer average ICU and total hospital length of stay, and a higher percentage of patients discharged to inpatient facilities. However, the operative group had lower mortality compared to the control groups. The operative group had 3 surgical site infections requiring readmission and hardware removal. Discussion Unlike other studies, our operative patients did not see improvements in time on mechanical ventilation, ICU and total hospital length of stay, or disposition at discharge, but did see a mortality benefit. Confounding factors include higher average ISS in the operative group, and over-sedation in the ICU. Data collection is ongoing, and refinements are being made to perioperative and ICU management to minimize these confounding variables.
The combination approach with Rhokinase inhibition and mechanical circulatory support in myocardial ischemia-reperfusion injury: Rho-kinase inhibition and ventricular unloading
Authors: Miyahara Shunsuke , Jenke Alexander , Yazdanyar Mariam , Kistner Julia , Immohr Moritz Benjamin , Sugimura Yukiharu , Aubin Hug , Kamiya Hiroyuki , Okita Yutaka , Lichtenberg Artur , Akhyari Payam 
Published: July 2022

Background It remains unclear whether the Rho-kinase (ROCK) inhibition in combination with mechanical circulatory support (MCS) had a synergic protective effect on myocardial ischemia (MI)/reperfusion injury in therapeutic strategies for acute myocardial infarction (AMI). We report the results of an approach using a rat model consisting of a miniaturized cardiopulmonary bypass (CPB) and AMI. Methods A total of 25 male Wistar rats were randomized into 5 groups: (1) Sham: a suture was passed under the left anterior descending artery (LAD) creating no MI. A vehicle solution (0.9% saline) was injected intraperitoneally. (2) Myocardial ischemia (MI) + vehicle (MI + V): LAD was ligated for 30 min and reperfused for 120 min, followed by administration of vehicle solution. (3) MI + fasudil (MI + F): the work sequence of group 2, but the selective ROCK inhibitor fasudil (10 mg/kg) was administered instead. (4) MI + V + CPB: CPB was initiated 15 min after the ligation of the LAD to the end of the reperfusion, in addition to the work sequence in group 2. (5) In the MI + F + CPB group, the work sequence of group 4, but with fasudil administration (10 mg/kg). Results Measurements of cardiac function through conductance catheter indicated that the drop of + dP/dt after reperfusion was moderately limited in MI + F + CPB (vs. MI + V, dP/dt p = 0.22). The preload recruitable stroke work was moderately improved in the MI + F + CPB ( p = 0.23) compared with the corresponding control animals (MI + V). Phosphorylated protein kinase B expression in the MI + V + CPB and MI + F + CPB was higher than that in MI + V ( p = 0.33). Conclusion Therefore, fasudil administration with MCS resulted in a moderately better left ventricular performance.
Trends of Change in Empathy Among Indian Medical Students: A Two-Year Follow-Up Study
Authors: Bhatia Gayatri , Shetty Jyoti V. 
Published: July 2022

Background: The development of an empathic approach is essential for doctor–patient relationships. Medical training is a challenging time that may affect empathy. This study aimed to assess the change in empathy in students during medical education. Methods: One hundred and fifty MBBS students were recruited at admission and assessed for empathy, interpersonal reactivity, and general health. They were followed for two years and assessed at three intervals. Results: A significant decline was seen in empathy for both male and female students. The decline was correlated with psychological stress. Gender, family structure, having siblings, and increasing General Health Questionnaire score predicted change in empathy. Conclusion: Empathy declines with advancing training, varying with constitutional and situational factors. The medical curriculum should include skills like empathic communication as well.
Development of a Personalized Tobacco Cessation Intervention Package (PTCIP) for Persons with Schizophrenia in India
Authors: Rajalu Banu Manickam , Jayarajan Deepak , Muliyala Krishna Prasad , Sharma Priyamvada , Gandhi Sailaxmi , Chand Prabhat Kumar 
Published: July 2022

Background: Among persons with schizophrenia (PwS), tobacco use is higher in comparison to the general population, contributing to greater morbidity and mortality. Pharmacological interventions combined with psychosocial interventions are effective in tobacco cessation. While the effectiveness of extant psychosocial interventions—when used in isolation—seems limited, developing better combinations of interventions could help treatment providers deliver tobacco cessation services to PwS at different stages of motivation to quit. We aimed to develop a personalized tobacco cessation intervention package (PTCIP) for PwS. Methods: The stage-based intervention package was developed through a systematic review of interventions for tobacco cessation, the authors’ clinical experience, and expert validation. The components of the intervention package, developed for PwS visiting the outpatient psychiatric department, were retained, removed, or added based on the content validity ratio (CVR). Results: The final components included brief advice, principles of motivational interviewing, psychoeducation, decisional balance matrix, positive reinforcement, offering various treatment options, personalized feedback using a smoking-risk calculator, and prediction of cardiovascular risk using the WHO package of essential noncommunicable disease (PEN). The delivery of the intervention package was refined based on pilot testing in eight participants. Conclusion: The tailored package was designed to be delivered by a mental health professional as a single comprehensive 40 min to 45 min face-to-face session, integrated with routine follow-up visits, followed by two telephonic conversations in the second and third week of the initial session. The package needs to be tested in a randomized controlled trial for its effectiveness.
Early trends in ECMO mortality during the first quarters of 2019 and 2020: Could we have predicted the onset of the pandemic?
Authors: Awori Hayanga J.W. , Kakuturu Jahnavi , Toker Alper , Asad Fatima , Siler Anthony , Hayanga Heather , Badhwar Vinay 
Published: July 2022

Objective To compare mortality trends in patients requiring Extracorporeal Membrane Oxygenation (ECMO) support between the first quarters of 2019 and 2020 and determine whether these trends might have predicted the severe acute respiratory syndrome coronavirus-2 (SARS)-Cov-2 pandemic in the United States. Methods We analyzed 5% Medicare claims data at aggregate, state, hospital, and encounter levels using MS-DRG (Medicare Severity-Diagnosis Related Group) codes for ECMO, combining state-level data with national census data. Necessity and sufficiency relations associated with change in mortality between the 2 years were modeled using qualitative comparative analysis (QCA). Multilevel, generalized linear modeling was used to evaluate mortality trends. Results Based on state-level data, there was a 3.36% increase in mortality between 2019 and 2020. Necessity and sufficiency evaluation of aggregate data at state and institutional levels did not identify any association or combinations of risk factors associated with this increase in mortality. However, multilevel and generalized linear models using disaggregated patient-level data to evaluate institution mortality and patient death, identified statistically significant differences between the first ( p = .019) and second ( p = .02) months of the 2 years, the first and second quarters ( p < .001 and p = .042, respectively), and the first 6 months ( p < .001) of 2019 and 2020. Conclusion Mortality in ECMO patients increased significantly during the first quarter of 2020 and may have served as an early warning of the SARS-Cov-2 pandemic. Granular data shared in real-time may be used to better predict public health threats.
Thermal, electrical and mechanical properties of carbon fiber/copper powder/carbon black reinforced hybrid Polyamide 6,6 composites
Authors: Beyaz Rumeysa , Ekinci Aysun , Yurtbasi Zühal , Oksuz Mustafa , Ates Murat , Aydin Ismail 
Published: July 2022

The development of low electrical and thermal properties of Polyamide (PA), which is used in place of metals in engineering applications, draws attention to the developments in various industrial disciplines. In this study, the effects of metal and carbon based fillers on the properties of Polyamide 6,6 (PA 6,6) were investigated. Especially, copper powder (Cu), carbon black (CB), carbon fiber (CF) and hybrid fillers (Cu/CB/CF) reinforced composites based on PA 6,6 were prepared by twin-screw extruder followed by injection molding. In the microstructure investigation, it was observed that the dispersion properties of used fillers were different in the PA 6,6 matrix. Both electrical and thermal conductivity of the PA 6,6 composites prepared were higher than pure PA 6,6. The highest electrical and thermal conductivity values were obtained as 7.97x10−2 S/cm and 0.73 W/mK for PA 6,6/CB30 and PA 6,6/CF/CB/Cu 10, respectively. The effects of the fillers on melting and crystallization behaviors and mechanical properties that affect the performance of PA 6,6 composites are also discussed. In general, the results showed that the mechanical properties of PA 6,6 composites were improved with the increase in the amount of hybrid filler. The highest tensile and notched Charpy impact strength were obtained as 252 MPa and 8.84 kJ/m2 in PA 6,6 composite with 30% carbon fiber reinforcement by volume. As a result, the tensile properties of PA 6,6 hybrid composite were found to be superior to PA 6,6/CF composite with the same amount of carbon fiber content.
High-order pseudorange rate measurement model for multi-constellation LEO/INS integration: Case of Iridium-NEXT, Orbcomm, and Globalstar
Authors: Farhangian Farzan , Landry Rene Jr 
Published: July 2022

An inertial navigation method augmented by Signals of Opportunity (SOPs) of three low earth orbit (LEO) constellations is presented. The downlink signal characteristics of the Iridium-NEXT, Orbcomm, and Globalstar LEO constellations are discussed. Furthermore, a tightly coupled integration model of the inertial navigation system and high-order LEO-SOP Doppler measurement model is designed. We presented a second-order measurement model of the LEO-SOP/INS integration using a second-order extended Kalman filter in which all the unknown states of the receiver and LEO satellites are estimated. The state parameters of the second-order EKF model are the position and velocity of both the receiver and the satellites, as well as the receiver’s orientation, the clock bias, and clock drift of the LEO satellites, and the constant bias of the Inertial Measurement Unit. An experiment is performed using a ground aerial vehicle equipped with a Multi-Constellation Software-Defined Receiver (MC-SDR). The Doppler measurements are provided by observing the downlinks from multiple satellites of the Iridium-NEXT and Orbcomm constellations. As well, the predicted measurement of a Globalstar satellite is used in the designed model. The results show the positioning accuracy of less than 10 m being achieved during a dynamic ground experiment, representing an 82% precision gain as compared against the regular single constellation EKF method.
Temporal trends in hospitalisation for opportunistic infections in lupus patients in Western Australia
Authors: Nossent Johannes , Keen Helen , Preen David B , Inderjeeth Charles A 
Published: July 2022

Background Lupus patients often require aggressive immunosuppressive therapy, which increases the risk for infections. We studied the temporal rates for opportunistic infections (OI) and associated mortality in lupus patients hospitalised in Western Australia. Methods All patients hospitalized in the period 1985–2015 with ≥2 ICD based diagnostic codes for SLE were included. OI was defined as a microbiologically confirmed mycobacterial, fungal, or viral infection. Descriptive data are given as median (IQR) and frequency (%) with incidence rates (IR) calculated per 1000 person years and IR trend rates analysed across 10-year periods by least square regression (R2). Results The study cohort (n = 1408) contained 85.3% females with age at entry 35 years (IQR 22–51). During median follow-up of 21.1 years (IQR 17.5–29.6) hospitalisation for OI occurred in 121 (8.6%) patients with recurrent or multiple OI observed in 42 (34.7%) patients. During 29.771 thousand person years, a total of 295 OI were diagnosed for an overall IR rate of 9.91 (CI 8.82–11.09)/1000 person years which did not decrease significantly over time (R2 0.14). Significant decreases were however seen in the IR for tuberculosis (R2 0.88), cryptococcal (R2 0.98) and pneumocystis (R2 0.98) infections, with increasing IR observed for other mycobacteria (R2 0.99) and aspergillosis (R2 0.55) and little change seen for H Zoster (R2 0.18) and Varicella (R2 0.10) infections. In-hospital death during OI admission occurred in 9/121 patients (7.4%). There was no significant gender difference in IR or outcome of OI. Conclusions Hospitalization rates for OI in lupus patients have not changed significantly over time, but there has been a clear shift in the underlying OI. The decrease in mycobacterial and pneumocystis infections suggest successful prophylaxis but the increase in viral and mycotic infections indicate a sustained need to improve prevention of these OI in lupus patients.
Comparison of outcomes of different osteotomy sites for hallux valgus: A systematic review and meta-analysis
Authors: Fukushi Jun-ichi , Tanaka Hirofumi , Nishiyama Takayuki , Hirao Makoto , Kubota Makoto , Kakihana Masataka , Nozawa Daisuke , Watanabe Kota , Okuda Ryuzo 
Published: July 2022

Background Hallux valgus (HV) is a common foot deformity for which several corrective surgical procedures, with different osteotomy sites, have been reported. The purpose of the present study was to systematically review randomized (RCTs) or controlled (CCTs) clinical trials and perform meta-analysis on outcomes of different osteotomy sites of the first metatarsal. Methods An extensive literature search was conducted in PubMed and the Cochrane Library from January 1983 to July 2020. Studies were identified using the terms “hallux valgus” and “osteotomy”. We included RCTs or CCTs comparing different locations of osteotomy for the first metatarsal bone (distal vs. mid-shaft, distal vs. proximal, and mid-shaft vs. proximal). The surgical outcomes included postoperative hallux valgus angle (HVA), intermetatarsal angle (IMA), American Orthopaedic Foot and Ankle Society (AOFAS) score, pain visual analog scale (VAS) score, perioperative complications and recurrence of deformity. We enrolled 10 studies with a total of 793 feet in the qualitative synthesis following full-text screening. Results A majority of patients included in the enrolled trials showed mild to moderate deformity, with mean HVA <40°. Out of the 10 enrolled studies; six compared distal osteotomies with mid-shaft osteotomies and showed no significant differences in the surgical outcomes between the scarf and chevron groups; three RCTs compared distal osteotomies with proximal osteotomies with conflicting results, one RCT showed the superiority of proximal osteotomy while the other two RCTs showed equivalent outcomes; one study that compared between mid-shaft and proximal osteotomies showed equivalent outcomes between the groups. Conclusion For the management of mild to moderate HV deformity, we found no significant clinical and radiological differences between patients treated with scarf and chevron osteotomies. Further controlled trials comparing different sites of osteotomies for moderate to severe HV deformity are needed.
The Impact of Nurses’ Beliefs, Attitudes, and Cultural Sensitivity on the Management of Patient Pain
Authors: Kuhlmann Emily H. , Tallman Benjamin A. 
Published: July 2022

Introduction: Nurses’ attitudes and beliefs may impact pain management. This study investigated nurses’ perceptions regarding their own and patients’ pain experiences by examining relationships between pain cautiousness and stoicism, cultural sensitivity, and personal pain attitudes. Methodology: A correlational methodology examined nursing staff in a Midwestern private hospital. The sample included 102 primarily female (95.1%), Caucasian (97%), and married (66%) nursing staff. Measures included the Intercultural Sensitivity Scale, Pain Attitudes Questionnaire to Assess Stoicism and Cautiousness, and the Pain Management: Nurses’ Knowledge and Attitude Survey. Results: Cultural sensitivity was a significant predictor of pain knowledge and attitudes total score ( R2 = .081, β = .244, p = .040), while pain stoicism and pain cautiousness were not predictive. Discussion: Findings highlight the importance of nurses being aware of personal attitudes, beliefs, and cultural sensitivity in pain management. Results also demonstrate a gap between the knowledge and utilization of nonpharmacologic pain management interventions among nursing staff.