bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in Racial and Ethnic Diversity in Vascular Neurology Fellowships From 2006 to 2018: A Cross-Sectional Analysis
Authors: Das Saurav , Farkas Nathan , Binkley Michael , Williams Jonathan , Ebong Ima M. , Akca Ozan , Ford Andria , Van Stavern Renee , Zazulia Allyson 
Published: February 2022

Background:
Workforce diversity in vascular neurology is a crucial component of reducing disparities in stroke care and outcomes. The objective of this study is to describe trends in the racial and ethnic diversity of neurology residents pursuing vascular neurology fellowship and propose an actionable plan for improvement.

Methods:

This was a cross-sectional study of race/ethnicity of neurology residents and vascular neurology fellows using published Graduate Medical Education census reports from 2006, when race/ethnicity data were first included, to 2018. Percentage of trainees underrepresented in medicine are reported for 3-year epochs and were analyzed using the Cochran-Armitage test (χ
2
test for trend).

Results:

Across the study period, underrepresented in medicine representation has not changed significantly among all neurology residents and subspecialty fellows (11.9% in 2006–2009; 12.5% in 2015–2018,
P
=0.82) nor among neurology residents alone (12.0% in 2006–2009; 12.6% in 2015–2018,
P
=0.81). Among vascular neurology fellows, however, there was a significant downtrend of underrepresented in medicine representation from 16.9% in 2006 to 2009 to 9.3% in 2015 to 2018 (
P
=0.013).

Conclusions:
Racial/ethnic underrepresentation among all neurology residents as well as those pursuing vascular neurology fellowship has persisted across the study period. Concerted efforts should be pursued to increase diversity in neurology residents and vascular neurology fellowship training.
Functional Investigation of Meningeal Lymphatic System in Experimental Intracerebral Hemorrhage
Authors: Tsai Hsin-Hsi , Hsieh Yung-Chia , Lin Jhih Syuan , Kuo Zi-Ting , Ho Chi-Ying , Chen Chih-Hung , Chang Che-Feng 
Published: February 2022

Background:
Promotion of hematoma resolution in a timely manner reduces intracerebral hemorrhage (ICH) brain injury induced by toxic blood components and subsequent neuroinflammation. The meningeal lymphatic system is responsible for clearance of macromolecules and pathogenic substances from the central nervous system; however, its role in intraparenchymal hematoma clearance and ICH outcomes is unknown. In the present study, we aimed to understand the contribution of the meningeal lymphatic system to ICH pathologies and to test whether pharmacological enhancement of meningeal lymphatic function promotes hematoma resolution and brain recovery after ICH.

Methods:
Immunofluorescence of whole-mount meninges was used to measure complexity and coverage level of meningeal lymphatic vasculature following ICH induction. Fluorescent microbeads and PKH-26-labeled erythrocytes were used to evaluate drainage function of the meningeal lymphatic system. Visudyne treatment, deep cervical lymph node ligation, and VEGF (vascular endothelial growth factor)-C injection were performed to manipulate meningeal lymphatic function. Neurobehavioral performance and hematoma volume were assayed by the cylinder test and histological measurements. Iron deposition, residual erythrocytes, neuronal loss, and astrogliosis were assessed by immunohistochemistry and antibody-based fluorescence staining.

Results:
Meningeal lymphangiogenesis and enhanced lymphatic drainage occurred during the late phase of ICH. Ablation and blockage of meningeal lymphatic vessels impeded hematoma clearance, whereas pharmacological enhancement of their function reduced hematoma volume, improved behavioral performance, and reduced brain residual erythrocytes, iron deposition, neuronal loss, and astroglial activation.

Conclusions:
Early enhancement of meningeal lymphatic function is beneficial for ICH recovery. Targeting the meningeal lymphatic system is therefore a potential therapeutic approach for treating ICH.
The Importance of Noise Colour in Simulations of Evolutionary Systems
Authors: Grove Matt , Timbrell Lucy , Jolley Ben , Polack Fiona , Borg James M. 
Published: February 2022

AbstractSimulations of evolutionary dynamics often employ white noise as a model of stochastic environmental variation. Whilst white noise has the advantages of being simply generated and analytically tractable, empirical analyses demonstrate that most real environmental time series have power spectral densities consistent with pink or red noise, in which lower frequencies contribute proportionally greater amplitudes than higher frequencies. Simulated white noise environments may therefore fail to capture key components of real environmental time series, leading to erroneous results. To explore the effects of different noise colours on evolving populations, a simple evolutionary model of the interaction between life-history and the specialism-generalism axis was developed. Simulations were conducted using a range of noise colours as the environments to which agents adapted. Results demonstrate complex interactions between noise colour, reproductive rate, and the degree of evolved generalism; importantly, contradictory conclusions arise from simulations using white as opposed to red noise, suggesting that noise colour plays a fundamental role in generating adaptive responses. These results are discussed in the context of previous research on evolutionary responses to fluctuating environments, and it is suggested that Artificial Life as a field should embrace a wider spectrum of coloured noise models to ensure that results are truly representative of environmental and evolutionary dynamics.
Perilesional Perfusion in Chronic Stroke-Induced Aphasia and Its Response to Behavioral Treatment Interventions
Authors: Walenski Matthew , Chen Yufen , Litcofsky Kaitlyn A. , Caplan David , Kiran Swathi , Rapp Brenda , Parrish Todd B. , Thompson Cynthia K. 
Published: February 2022

Abstract
Stroke-induced alterations in cerebral blood flow (perfusion) may contribute to functional language impairments in chronic aphasia, particularly in perilesional tissue. Abnormal perfusion in this region may also serve as a biomarker for predicting functional improvements with behavioral treatment interventions. Using pseudo-continuous arterial spin labeling in magnetic resonance imaging (MRI), we examined perfusion in chronic aphasia, in perilesional rings in the left hemisphere and their right hemisphere homologues. In the left hemisphere we found a gradient pattern of decreasing perfusion closer to the lesion. The opposite pattern was found in the right hemisphere, with significantly increased perfusion close to the lesion homologue. Perfusion was also increased in the right hemisphere lesion homologue region relative to the surrounding tissue. We next examined changes in perfusion in two groups: one group who underwent MRI scanning before and after three months of a behavioral treatment intervention that led to significant language gains, and a second group who was scanned twice at a three-month interval without a treatment intervention. For both groups, there was no difference in perfusion over time in either the left or the right hemisphere. Moreover, within the treatment group pre-treatment perfusion scores did not predict treatment response; neither did pre-treatment perfusion predict post-treatment language performance. These results indicate that perfusion is chronically abnormal in both hemispheres, but chronically abnormal perfusion did not change in response to our behavioral treatment interventions, and did not predict responsiveness to language treatment.
Gravity Wave Generation in Balanced Sheared Flow Revisited
Authors: Chouksey Manita , Eden Carsten , Olbers Dirk 
Published: February 2022

Abstract
The generation of internal gravity waves from an initially geostrophically balanced flow is diagnosed in nonhydrostatic numerical simulations of shear instabilities for varied dynamical regimes. A nonlinear decomposition method up to third order in the Rossby number (Ro) is used as the diagnostic tool for a consistent separation of the balanced and unbalanced motions in the presence of their nonlinear coupling. Wave emission is investigated in an Eady-like and a jet-like flow. For the jet-like case, geostrophic and ageostrophic unstable modes are used to initialize the flow in different simulations. Gravity wave emission is in general very weak over a range of values for Ro. At sufficiently high Ro, however, when the condition for symmetric instability is satisfied with negative values of local potential vorticity, significant wave emission is detected even at the lowest order. This is related to the occurrence of fast ageostrophic instability modes, generating a wide spectrum of waves. Thus, gravity waves are excited from the instability of the balanced mode to lowest order only if the condition of symmetric instability is satisfied and ageostrophic unstable modes obtain finite growth rates.

Significance Statement
We aim to understand the generation of internal gravity waves in the atmosphere and ocean from a flow field that is initially balanced, i.e., free from any internal gravity waves. To examine this process, we use simulations from idealized numerical models and nonlinear flow decomposition method to identify waves. Our results show that a prominent mechanism by which waves can be generated is related to symmetric or ageostrophic instabilities of the balanced flow possibly occurring during frontogenesis. This process can be a significant mechanism to dissipate the energy of the geostrophic flow in the ocean.
The training needs of critical care nurses: A psychometric analysis
Authors: Santana-Padilla Yeray Gabriel , Bernat-Adell María Desamparados , Santana-Cabrera Luciano 
Published: February 2022

Background/Objective: Nurses develop the care methods they learn through specific training and this enables them to provide care in a safe, effective and efficient manner. Intensive Care Units (ICU), as complex areas in terms of care, require nurses with specific training. Due to this fact, we set ourselves the objective to validate a questionnaire that detects the training needs of intensive care nurses in Spain. Methods: A cross-sectional descriptive study, using an electronic questionnaire, adapted and validated through the Delphi technique, in 85 ICUs in Spain, for which a psychometric analysis is conducted. To explore the dimensions and determine the factorial structure, an Exploratory Factor Analysis (EFA) and a Confirmatory Factor Analysis (CFA) were carried out. Internal consistency was determined through ordinal alpha. The statistical treatment was carried out using the statistical programmes Factor Analysis 10.9.02 and IBM AMOS version 24. Results: A total of 568 Spanish intensive care nurses, randomly divided into two samples, participated in the study. The EFA presented a factorial solution with suitable values for both the Kaiser-Meyer-Olsen Index and Bartlett's Sphericity. In the CFA, the model fit achieved close to ideal values with a Comparative Fit Index (CFI) and Tucker-Lewis Index (TLI) close to values of 0.9. The values of individual reliability, internal consistency and average variance extracted were appropriate for this type of analysis. Conclusion: The dimensions detected are close to the construct that encompasses the training needs of ICU nurses. The analyses carried out indicate that there are reasonable realities for incorporating these dimensions into the field of nursing training. This study opens the possibility of incorporating new items to adjust the model to improve the explanatory variables. Our findings help us to understand the dimensions that the training programmes should incorporate.
Evaluation of lung cancer biomarkers profile for the decision of targeted therapy in EBUS-TBNA cytological samples
Authors: Gürün Kaya Aslıhan , Çiledağ Aydın , Erol Serhat , Öz Miraç , Doğan Mülazımoğlu Deniz , Işık Özlem , Özakıncı Hilal , Çiftçi Fatma , Şen Elif , Ceyhan Koray , Kaya Akın , Karnak Demet , Çelik Gökhan , İsmail Savaş 
Published: February 2022

Background Guidelines recommend performing biomarker tests for epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), BRAF and ROS proto-oncogene-1(ROS1) genes and protein expression of programmed death ligand-1(PD-L1) in patients with non-small lung cell carcinoma (NSCLC). Studies reported that endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) can provide sufficient material for cancer biomarker analyses, but there are still concerns about the subject. Aim The purpose of the study was to assess the adequacy of EBUS-TBNA for testing lung cancer biomarkers. Methods We retrospectively reviewed patients with NSCLC whose EBUS-TBNA was analysed for EGFR, ALK, ROS-1, BRAF and PD-L1 expression between December 2011 and December 2020. Results A total of 394 patients were enrolled in the study. EGFR mutation and ALK fusion were the most common studied biomarkers. EBUS-TBNA adequacy rate for biomarker tests was found 99.0% for EGFR, 99.1 for ALK, 97.2% for ROS1, 100% for BRAF and 99.3% for PD-L1 testing. Multivariate analysis revealed the histological type, history of treatment for NSCL, size, or 18-fluorodeoxyglucose uptake of sampled lesion did not show any association with TBNA adequacy for biomarker testing. Conclusion EBUS-TBNA can provide adequate material for biomarker testing for EGFR, ALK, ROS-1, BRAF and PD-L1 expression.
Identifying current driver rehabilitation practices for clients with physical impairments
Authors: Langereis Brittany , Semeniuk Sarah , Kristalovich Lisa , Mortenson W.Ben 
Published: February 2022

Introduction Driving is an important occupation that influences a person’s ability to access community resources and participate in meaningful activities. Occupational therapists and other clinicians who are trained as driver rehabilitation specialists provide interventions to improve function and independence in driving. The objective of this study was to examine consistency of adaptive driving equipment prescription and driver retraining recommendations for clients with physical impairment and identify factors that influence driver rehabilitation recommendations. Methods Clinicians practicing in Canada and the United States were surveyed electronically. Data were analyzed using descriptive statistics and content analysis. Results Out of 36 respondents, the majority (97.2%) were occupational therapists. Completion of in-clinic (97.0%) and on-road (84.4%) evaluations were consistent among the majority of respondents, yet components comprising evaluations varied. Fewer respondents were in agreement in equipment recommendations for secondary controls. Respondents emphasized the importance of clinical reasoning skills when making equipment and intervention recommendations. Conclusion Further development of clinical guidelines and advanced training in driver rehabilitation may be beneficial to facilitate clinical reasoning and improve consistency of practice.
Return to Sports and Patients’ Rehabilitation Continuum After Deepening Trochleoplasty and Concomitant Patellar-Stabilizing Procedures: A Case Series of 111 Patients at 2 to 4 Years of Follow-up
Authors: Mengis Natalie , Zimmermann Felix , Schemel Larissa , Rippke Jules N. , Milinkovic Danko D. , Balcarek Peter 
Published: February 2022

Background: There are few reports on the return to sports after complex patellar-stabilizing surgery. Purposes: To evaluate patients’ ability to return to sports and to investigate the extent to which the preoperative level of sports participation influences sports activity after deepening trochleoplasty (TP) and concomitant patellar-stabilizing procedures. Study Design: Case series; Level of evidence, 4. Methods: Between April 2015 and April 2019, 144 patellar-stabilizing procedures, including deepening TP and medial patellofemoral ligament reconstruction or medial reefing with and without concomitant realignment procedures, were carried out in 142 patients. The Banff Patellofemoral Instability Instrument 2.0 (BPII 2.0) and the Tegner activity score were used to assess patients’ quality of life and sports activity level. In addition, a numerical analog scale was used to evaluate patellofemoral pain intensity during rest and activity and subjective knee joint function. Results: Outcomes were available for 111 patients (112 knees) (male/female, 77/34; mean age, 23.4 ± 7.8 years), yielding a 77.7% follow-up rate at a mean of 39.2 ± 9.9 months (range, 24-48 months). Two-thirds of the patients returned to their preoperative level of activity or higher, but their Tegner scores did not change significantly (4.5 ± 2.4 vs 4.7 ± 1.6; P = .365). Low-level athletes (preoperative Tegner score 0-4) participated at a higher level of sports activity (2.7 ± 1.4 to 4.1 ± 1.2; P < .0001), whereas higher-level athletes (preoperative Tegner score 5-10) participated at a lower level (6.8 ± 1.3 to 5.5 ± 1.7; P < .0001). The likelihood of returning to the preoperative activity level (Tegner score) was significantly higher in the low-level activity group than in the high-level activity group ( P = .0001; 95% CI, 4.055-27.05; odds ratio, 10.47). All of the patient-reported outcome measures improved postoperatively, independent of the patients’ age, sex, and body mass index. Conclusion: Patients undergoing deepening TP and medial soft tissue stabilization with or without concomitant realignment surgery for complex patellar instability can expect good clinical results and a high rate of return to sports participation, with two-thirds of patients returning to their preoperative Tegner-level of activity or higher. However, higher-level athletes should be informed that their likelihood of returning to sports at the preoperative level or full participation at a competitive level is reduced.
Gender Differences in Financial Decision-Making and Behaviors in Single and Joint Households
Authors: Wagner Jamie , Walstad William B. 
Published: February 2022

This study investigates gender differences in household financial behavior using data from the 2018 National Financial Capability Study, a large and nationally representative survey about adults’ financial behavior, knowledge, and attitudes. The behaviors include paying your credit card in full each month, having a 3-month emergency fund, having non-retirement investments, and having a non-employer retirement account. Results showed that single females were significantly less likely to engage in any of the financial behaviors compared to men. Additionally, females in joint households were also significantly less likely to engage in the behaviors compared to males. These results are robust when splitting the single and joint household samples by age, level of financial literacy, and using a sample from a prior year. Therefore, females may not be well-prepared for financial decision-making in single or joint households, which can have adverse consequences for managing current personal finances and building wealth for the future. JEL codes: D12, D14, I21
Tribological and thermal characteristics of an epoxy-based composite containing polyaryletherketone
Authors: Hu Haixia , Shu Rui , Meng Limin , Yu Tiansheng , Wang Chengjun , Chen Dingming , Shen Yuzhe 
Published: February 2022

Current research work focuses on the tribological and thermal properties of epoxy resin matrix composites, which were modified by polyaryletherketone (PAEK-C). The results of the infrared spectra and morphologies of fracture surfaces experiments corroborate the successful synthesis of the materials. From the tribological experiments, it can be known that when the mass fraction of PAEK-C was 10 phr., the corresponding composite exhibited the outstanding wear performances, which could be ascribed to the higher H/E ratio. Based on the results of tribological experiments, it could be obtained that the main wear mechanism is governed by combination of the plastic deformation, creation of vertical cracks in the sliding track, separation of debris, and material waves due to adhesions. In addition, the glass transition temperatures ( Tg) and heat-resistance index ( THRI) of the PAEK-C/epoxy resin higher than those of pure epoxy resin matrix, respectively. Furthermore, when the mass fraction of PAEK-C increased, the heat resistance index ( THRI) of the corresponding composite is 196.3°C, which is higher than that of neat epoxy resin (180.9°C). Also, according to the results of thermogravimetric analysis experiments, it could conclude that the activation energy of the curing process is situated in the range of 150–160 kJ mol−1 depending on the mass fraction of epoxy resins.
Online self-sampling kits for human immunodeficiency virus and other sexually transmitted infections: Feasibility, positivity rates, and factors associated with infections in France
Authors: Rahib Delphine , Bercot Béatrice , Delagreverie Héloïse , Gabassi Audrey , Delaugerre Constance , Salord Hélène , Icard Vinca , Le Thi Than-Thuy , Leveau Benjamin , Khiri Hacène , Digne Julien , Didelot Marie-Noëlle , Pisoni Amandine , Tuaillon Edouard , Lydié Nathalie , Vandentorren Stéphanie 
Published: February 2022

Background Men who have sex with men are increasingly diagnosed with sexually transmitted infections (STI) in France. To address this situation, quarterly screening for HIV combined with hepatitis B (HBV) and hepatitis C (HCV), as well as annual screening for C.trachomatis (CT) and N.gonorrhoeae (NG) are recommended. The MemoDepistages program offered an at-home screening solution for these infections. This study describes the feasibility of this screening process, the rate of positive test results, and the factors associated with positivity. Methods Participants were recruited online. Laboratories verified the quantity and quality of the samples. Logistic regression was used to determine the associated factors for infection. Results Overall, 1556 out of 1908 (81.6%) blood samples were tested for at least HIV. A total of eight participants (0.5%) were newly diagnosed with HIV and four with HCV (0.3%). No new infection was confirmed for HBV. Overall positivity was 9.3% for CT and 9.6% for NG. The highest positivity was reported in rectal swabs for CT (7.3%) and in pharyngeal swabs for NG (7.2%). Factors associated with extragenital CT/NG were age under 30 years (for pharyngeal and rectal infections) and having at least 10 partners in the past 6 months ( p<0.001) (for pharyngeal infections only). Conclusions The self-sampling kit for multiple STIs can perform comprehensive tests and identify new infections in young people, especially in extragenital sites.
The impact of COVID-19 on benzodiazepine usage in psychiatric inpatient units
Authors: Zaki Nancy , Brakoulias Vlasios 
Published: February 2022

Objective This study aims to investigate whether COVID-19 has led to increased usage of benzodiazepines in acute psychiatric settings. Method We evaluated the rates of benzodiazepine usage in two acute psychiatric inpatient units over a period of two years, 2019 and 2020 (the year of the pandemic). Rates of oral atorvastatin usage over the same period were used as a comparator. Results We saw a significant increase in the usage of benzodiazepines in the period between April and December 2020 compared to the same period in 2019 despite a decline in the total number of admissions in 2020. Usage peaked further at the time of eased pandemic restrictions which coincided with higher rates of emergency department mental health (MH) presentations and acute MH hospital admissions. We also noticed higher rates of substance use disorder recorded on admission. Hospital leave restrictions due to COVID-19 also led to further restrictions on smoking. Conclusion Benzodiazepine usage increased in the context of the COVID-19 pandemic. The study encourages more research to better understand the impact of the pandemic on acute psychiatric settings.