bluuebunny/crossref_metadata_2025_split huggingface dataset:
High β‐carotene concentration in plasma enhances cyclic progesterone production in nonpregnant Japanese Black cows
Authors: Mitsuishi Hiroki , Natsubori Eri , Otsuka Tsuyoshi , Yayota Masato 
Published: November 2022

Abstractβ‐Carotene is an essential nutrient in cattle reproduction. The objective of this study was to evaluate the effect of β‐carotene supplementation on ovarian activities throughout the estrous cycle in nonpregnant Japanese Black cows. The estrous cycles of eight nonpregnant Japanese Black cows were synchronized using a double synch protocol, and the cows were divided into two groups. The cows in the β‐carotene (BC) group received supplementation with 1000 mg/day β‐carotene for 46 days including the synchronization period. The cows in the control (C) group did not receive β‐carotene supplementation. The results showed that β‐carotene supplementation at 1000 mg/day was sufficient to maintain a high plasma β‐carotene concentration and increase the plasma retinol concentration and that β‐carotene supplementation had no significant effects on the dominant follicle diameter, total number of estrus behaviors, or length of the estrous cycle. In contrast, the areas under the P4 concentration curves in the BC group were higher than those obtained for the C group. In conclusion, a high plasma β‐carotene concentration in Japanese Black cows promotes P4 production in the luteal phase of the estrous cycle and total P4 production throughout the estrous cycle without changing the length of the estrous cycle.
Over expression of ubiquitin‐conjugating enzyme E2O in bone marrow mesenchymal stromal cells partially attenuates acute myeloid leukaemia progression
Authors: Tian Chen , Chen Zehui , Wang Lina , Si Junqi , Kang Junnan , Li Yueyang , Zheng Yaxin , Gao Yanan , Nuermaimaiti Rexidan , You M. James , Zheng Guoguang 
Published: November 2022

SummaryBone marrow mesenchymal stromal cells (BM‐MSCs) are implicated in the pathogenesis of acute myeloid leukaemia (AML). However, due to the high heterogeneity of AML the mechanism underlying the cross‐talk between MSCs and leukaemia cells is not well understood. We found that mixed‐lineage leukaemia‐AF9 (MLL‐AF9)‐induced AML mice‐derived MSCs had higher proliferative viability compared to wild‐type mice‐derived MSCs with ubiquitin‐conjugating enzyme E2O (Ube2o) down‐regulation. After overexpression of UBE2O in AML‐derived MSCs, the growth capacity of MSCs was reduced with nuclear factor kappa B subunit 1 (NF‐κB) pathway deactivation. In vitro co‐culture assay revealed that UBE2O‐overexpression MSCs suppressed the proliferation and promoted apoptosis of AML cells by direct contact. In vivo results revealed that the leukaemia burden was reduced and the overall survival of AML mice was prolonged, with decreased dissemination of leukaemia cells in BM, spleen, liver and peripheral blood. Additionally, subcutaneous tumorigenesis revealed that tumour growth was also suppressed in the UBE2O‐overexpression MSCs group. In conclusion, UBE2O was expressed at a low level in MLL‐AF9‐induced AML mice‐derived MSCs. Overexpression of UBE2O in MSCs suppressed their proliferation through NF‐κB pathway deactivation, which resulted in AML suppression. Our study provides a theoretical basis for a BM microenvironment‐based therapeutic strategy to control disease progression.
Let's talk about faces: Identifying faces from verbal descriptions
Authors: Tyler Rebecca , Towler Alice , Kemp Richard I. , White David 
Published: November 2022

AbstractFace descriptions inform real‐world identification decisions, for example when eyewitnesses describe criminal perpetrators. However, it is unclear how effective face descriptions are for identification. Here, we examined the accuracy of face identification from verbal descriptions, and how individual differences in face perception relate to producing and using descriptions for identification. In Study 1, participants completed a face communication task in pairs. Each participant saw a single face, and via verbal communication only, the pair decided if they were viewing the same person or different people. Dyads achieved 72% accuracy, compared to 81% when participants completed the task individually by matching face pairs side‐by‐side. Performance on the face communication and perceptual matching tasks were uncorrelated, perhaps due to low measurement reliability of the face communication task. In subsequent studies, we examined the abilities of face ‘describers’ (Study 2) and ‘identifiers’ separately (Study 3). We found that ‘super‐recognizers’ – people with extremely high perceptual face identification abilities – outperformed controls in both studies. Overall, these results show that people can successfully describe faces for identification. Preliminary evidence suggests that this ability – and the ability use facial descriptions for identification – has some association with perceptual face identification skill.
Identification of a novel ALDH1A3‐selective inhibitor by a chemical probe with unrelated bioactivity: An approach to affinity‐based drug target discovery
Authors: Kamiyama Hiroshi , Miyano Masayuki , Ito Daisuke , Kimura Takayuki , Hagiwara Koji , Kogai Hiroyuki , Kaburagi Yosuke , Kotake Yoshihiko , Takase Yasutaka 
Published: November 2022

AbstractThe identification of biologically active target compounds and their binding proteins is important in mechanism‐of‐action studies for drug development. Additionally, the newly discovered binding proteins provide unforeseen ideas for novel drug discovery and for subsequent structural transformation to improve target specificity. Based on the lead and final candidate compounds related to the type 5 phosphodiesterase (PDE5) inhibitor E4021, we designed chemical probes and identified their target proteins by the affinity chromatography approach. Aldehyde dehydrogenase family 1 member A3 (ALDH1A3), currently reported as a cancer stem cell target, was clearly isolated as a binding protein of the lead ‘immature’ inhibitor probe against PDE5. In the early derivatization to the closely related structure, Compound 5 (ER‐001135935) was found to significantly inhibit ALDH1A3 activity. The discovery process of a novel ALDH1A3‐selective inhibitor with affinity‐based binder identification is described, and the impact of this identification method on novel drug discovery is discussed.
Child care and family processes: Bi‐directional relations between child care quality, home environments, and maternal depression
Authors: Hart Emma R. , Vandell Deborah Lowe , Whitaker Anamarie A. , Watts Tyler W. 
Published: November 2022

AbstractThe current study examined whether within‐family changes in child care quality and quantity predicted subsequent changes in home environment quality and maternal depression across early childhood (6 to 54 months of age). Data were drawn from the NICHD Study of Early Child Care and Youth Development (n = 1239; 77% White; 48% female; data collection from 1991 to 1996), and were analyzed using Random Intercept Cross‐Lagged Panel Models. Within‐family increases in child care quality predicted modest increases in home environment quality (β = .13–.17). These effects were most robust from child age 6 to 15 months. Increases in child care quality produced small, statistically non‐significant, reductions in depression. Time‐specific increases in child care quantity were not consistently predictive of either outcome.
High‐dose oral glutamine supplementation reduces elevated glutamate levels in cerebrospinal fluid in patients with mitochondrial encephalomyopathy, lactic acidosis and stroke‐like episodes syndrome
Authors: Guerrero‐Molina María Paz , Morales‐Conejo Montserrat , Delmiro Aitor , Morán María , Domínguez‐González Cristina , Arranz‐Canales Elena , Ramos‐González Ana , Arenas Joaquín , Martín Miguel A. , de la Aleja Jesús González 
Published: November 2022

AbstractBackground and PurposeMitochondrial encephalomyopathy, lactic acidosis and stroke‐like episodes (MELAS) syndrome is a genetically heterogeneous disorder caused by mitochondrial DNA mutations. There are no disease‐modifying therapies, and treatment remains mainly supportive. It has been shown previously that patients with MELAS syndrome have significantly increased cerebrospinal fluid (CSF) glutamate and significantly decreased CSF glutamine levels compared to controls. Glutamine has many metabolic fates in neurons and astrocytes, and the glutamate–glutamine cycle couples with many metabolic pathways depending on cellular requirements. The aim was to compare CSF glutamate and glutamine levels before and after dietary glutamine supplementation. It is postulated that high‐dose oral glutamine supplementation could reduce the increase in glutamate levels.MethodThis open‐label, single‐cohort study determined the safety and changes in glutamate and glutamine levels in CSF after 12 weeks of oral glutamine supplementation.ResultsNine adult patients with MELAS syndrome (66.7% females, mean age 35.8 ± 3.2 years) were included. After glutamine supplementation, CSF glutamate levels were significantly reduced (9.77 ± 1.21 vs. 18.48 ± 1.34 μmol/l, p < 0.001) and CSF glutamine levels were significantly increased (433.66 ± 15.31 vs. 336.31 ± 12.92 μmol/l, p = 0.002). A side effect observed in four of nine patients was a mild sensation of satiety. One patient developed mild and transient elevation of transaminases, and another patient was admitted for an epileptic status without stroke‐like episode.DiscussionThis study demonstrates that high‐dose oral glutamine supplementation significantly reduces CSF glutamate and increases CSF glutamine levels in patients with MELAS syndrome. These findings may have potential therapeutic implications in these patients.Trial Registration InformationClinicalTrials.gov Identifier: NCT04948138. Initial release 24 June 2021, first patient enrolled 1 July 2021. https://clinicaltrials.gov/ct2/show/NCT04948138.
ERH: a plug‐and‐play protein important for gene silencing and cell cycle progression
Authors: Graille Marc 
Published: November 2022

In metazoans, most proteins have pleiotropic cellular functions and have the ability to interact with several factors to accomplish these different functions. This is the case of eukaryotic ERH proteins, a family of homodimeric proteins involved in DNA replication and cell cycle control as well as in gene silencing by contributing either to the biogenesis of small interference RNAs (miRNAs, piRNAs) or to the recruitment of RNA decay machineries. Very recently, several crystal structures describing complexes formed by eukaryotic ERH proteins and several small peptides from various partners have highlighted the existence of different binding sites on the surface of ERH proteins. In this issue of The FEBS Journal, Wang et al. present the crystal structure of the complex formed between the human ERH protein and a short peptide of the CIZ1 protein, one of its partners. Altogether, this information will be particularly important for future studies aimed at dissecting the different biological functions governed by this family of highly conserved proteins.Comment on: https://doi.org/10.1111/febs.16611
Finding and evaluating randomised controlled trials in nursing conducted by Spanish research teams: A scoping review
Authors: Medina‐Aedo Melixa , Torralba‐Martinez Elena , Segura‐Carrillo Cristian , Buitrago‐García Diana , Solà Ivan , Pardo‐Hernández Héctor , Bonfill Xavier 
Published: November 2022

AbstractBackground/objectivesTo identify and assess the main characteristics and the potential risk of bias of randomised controlled trials (RCTs) in nursing conducted by Spanish research teams.MethodsScoping review of an electronic search in three major databases (date of search: October 2021). For the eligible studies, both descriptive data, and data to assess the potential risk of bias, were collected and analysed.ResultsOf 3391 references retrieved, 199 were eligible. These RCTs were published in 122 journals, most of them in English (101, 82.1%) and were included in the Journal Citation Report (JCR) (107, 87.7%). Moreover, 32 (26.2%) of those included in the JCR were classified under nursing. Two thirds (81, 66.4%) of the journals followed the CONSORT guidelines. A total of 65 RCTs (33.7%) had a high overall risk of bias.DiscussionMost of the identified RCTs were published in journals not specific to nursing and in English language. Also, shortcomings in RCT design and reporting were observed despite recommendations to adhere the CONSORT guidelines.ConclusionComprehensive identification of RCTs in nursing may require searching in journals other than nursing‐related. RCTs from Spanish research teams are more likely to be published in international journals published in English. CONSORT should be strongly advised to encourage proper design and reporting of RCTs.
On the anion and cation positions within and nearby R(101¯2)$R(10\overline{1}2)$, Σ(202¯4)$\mathrm{\Sigma}(20\overline{2}4)$, and Π(101¯4)$\mathrm{\Pi}(10\overline{1}4)$ planes of α‐Al2O3 corundum structure
Authors: Lubarda Vlado A. , Lubarda Marko V. 
Published: November 2022

AbstractThe positions of aluminum cations and oxygen anions within and nearby the , , , and planes of α‐Al2O3 corundum structure are determined and compared with the corresponding ion positions within and nearby their conjugate‐adjacent planes , , , and planes. The plane contains neither aluminum nor oxygen ions, while the planes , , and contain only oxygen anions, whose planar densities are and . The planes , , and contain only aluminum cations with planar densities and . The plane contains both aluminum and oxygen ions, whose planar densities are and . The nearest ions to the , , , and planes are at a normal distance of 0.58 Å from these planes, which is one‐half of the normal distance between the adjacent R and , or r and planes. The ions nearest to the and planes are also at a normal distance of 0.58 Å from these planes. The nearest ions to the and planes are 0.85 Å from these planes, which is one‐half the interplanar spacing between the adjacent Π or π planes. The obtained results are of interest for the evaluation of ionic bonding and surface energies, epitaxial film growth over differently oriented sapphire substrates, and for the analysis of plastic deformation and cleavage fracture of sapphire crystals under different loading and temperature conditions.
Impact of coexisting diabetes on survival and risk of developing second primary cancer in diabetes patients receiving drug therapy: A multicenter retrospective cohort study of patients with cancer in Japan
Authors: Kuwabara Yoshihiro , Morishima Toshitaka , Odani Satomi , Kudo Haruka , Ma Chaochen , Kato Mizuki , Koyama Shihoko , Saito Mari Kajiwara , Nakata Kayo , Tabuchi Takahiro , Miyashiro Isao 
Published: November 2022

AbstractAims/IntroductionWe investigated the association between coexisting diabetes at the time of cancer diagnosis, and the overall survival and incidence of second primary cancer in patients with cancer and receiving drug therapy for diabetes.Materials and MethodsWe used cancer registry and administrative data of patients diagnosed with cancer at designated cancer care hospitals in Osaka Prefecture between 2010 and 2015. The presence of diabetes was identified from the prescription records of antidiabetic drugs in Diagnosis Procedure Combination System data. After adjusting for patient characteristics, we compared overall survival between patients with cancer with coexisting diabetes and those without coexisting diabetes using the Cox proportional hazards model. In addition, the impact of coexisting diabetes on the risk of developing second primary cancer was evaluated using a competing risk analysis.ResultsOf the 131,701 patients with cancer included in the analysis, 6,135 (4.7%) had coexisting diabetes. The 5‐year survival rates for patients with and without coexisting diabetes were 56.2% (95% confidence interval 54.8–57.6) and 72.7% (95% confidence interval 72.4–73.0), respectively. Coexisting diabetes was associated with a higher risk of developing second primary cancer (subdistribution hazard ratio 1.23; 95% confidence interval 1.08–1.41). In site‐specific analysis, coexisting diabetes was associated with an increased risk for the development of second primary cancer of multiple myeloma, and cancer of the uterus, pancreas and liver.ConclusionsCoexisting diabetes was associated with a higher mortality and risk of developing second primary cancer in Japanese patients with cancer and on drug therapy for diabetes.
Efficacy of chlorine, sodium chloride and trichlorfon baths against monogenean Dawestrema cycloancistrium parasite of pirarucu Arapaima gigas
Authors: de Araújo Pollyana Alves , Maciel‐Honda Patricia Oliveira , de Oliveira Costa‐Fernandes Thaís , dos Santos Gracienhe Gomes , Martins Maurício Laterça 
Published: November 2022

AbstractThis study investigated the efficacy of sodium chloride (SC) and trichlorfon (T) against Dawestrema cycloancistrium and its physiological effects on Arapaima gigas. The efficacy of chlorine (C) as a prophylactic disinfectant was also evaluated. In vitro test with 15 treatments were: SC 4, 8, 10, 12, 14 g/L, T0.1, 0.4, 0.8, 1.6, 3.2 mg/L, and C500, 1000, 3000, 6000 mg/L. Scanning electron microscopy was performed to evaluate parasite damage. The in vivo test was as follows: control, 4 h short baths, once a day, for four consecutive days (SC12 g/L, T5 mg/L); 24 h long baths, for 2 days in 24 h intervals (SC10 g/L, T5 mg/L). In vitro exposure to SC12 and 14 g/L caused 100% mortality of monogeneans at 45 and 60 min, while at T3.2 and 1.6 mg/L 100% of monogeneans died at 30 and 60 min, respectively. In vitro exposure to C resulted in complete mortality after 2–5 min exposure. The SC and T LD50–96 h were 9.9 g/L and 9.73 mg/L, respectively. All in vivo treatments presented efficacy above or close to 90%, with low survival in the long baths. C, starting at 500 mg/L for 5 min, can be used as a disinfectant. Short baths with SC12 g/L and T5 mg/L are recommended for D. cycloancistrium infestations in Arapaima.
Low‐grade duodenal eosinophilia is associated with cagA in Helicobacter pylori‐related dyspepsia
Authors: Barreyro Fernando Javier , Sanchez Nicolas , Caronia Maria Virginia , Elizondo Karina , Jordá Graciela , Schneider Adolfo , Zapata Pedro Dario 
Published: November 2022

AbstractBackground and AimFunctional dyspepsia (FD) is a multifactorial disorder. Helicobacter pylori (H. pylori)‐related dyspepsia (HpD) may be considered a separate entity. Duodenal eosinophilia is a potential pathogenic mechanism in FD. However, the impact of duodenal eosinophilia and H. pylori virulence genes in HpD was not explored. We aim to evaluate the association of H. pylori virulence genes and low‐grade duodenal eosinophilia in HpD.MethodsA multi‐center cross‐sectional study was conducted. A total of 301 patients who meet Rome‐III criteria were selected before upper endoscopy, and 95 patients were included after normal endoscopy and positive H. pylori in gastric biopsies were assessed. Clinical parameters, H. pylori virulence genes (cagA, oipA, and vacA) and duodenal histology were evaluated.ResultsSixty‐nine (72%) patients had epigastric pain syndrome (EPS), 17 (18%) post‐prandial distress syndrome (PDS) and 9 (10%) EPS/PDS overlap. FD syndromes were not associated with cagA or oipA strains. A significantly trend of vacA s1/m1 (78%) and s1/m2 (80%) positive strains in EPS was observed. Histological duodenal grading of chronic inflammation, low‐grade duodenal eosinophilia and intra‐epithelial lymphocytes showed no difference in oipA and vacA strains. Low‐grade duodenal eosinophilia was significant in cagA positive strain, and the OR for low‐grade duodenal eosinophilia with H. pylori cagA positive strain was 4.2 (95% CI, 1.78–9.93). Adjusting for age, gender, smoking, diabetes, alcohol, PPI, and NSAID, the OR was 5.44 (1.989–14.902).ConclusionOur findings suggest that low‐grade duodenal eosinophilia is significantly associated with cagA strain in HpD.
Marketing's contribution to consumer welfare: A research agenda
Authors: Stewart David W. 
Published: November 2022

AbstractThe marketing discipline emerged in the early 20th century in response to the needs for new institutions and processes for delivering goods and services to an increasingly urbanized and diverse market. Evidence suggests that the value delivery system(s) that have emerged have substantially improved consumer welfare. This history and success of the marketing discipline is frequently overlooked in discussions of markets and marketing. This paper suggests the need to place discussion of the role of marketing and its contributions to social welfare in an appropriate historical context. It also draws attention to the need for research on the complementary roles of markets and governments and the contributions, and diminutions, of each to consumer welfare. Finally, the paper suggests that marketing's unique contribution to improving consumer welfare and the quality of life resides in its unique perspective on value delivery systems.
Healthcare aide involvement in team decision‐making in long‐term care: A narrative review of the literature
Authors: Cranley Lisa A. , Yeung Lily , Tu Wendy , McGillis Hall Linda 
Published: November 2022

AbstractAims and ObjectivesTo provide an overview and synthesis of the current evidence on healthcare aides' involvement in team decision‐making in long‐term care.BackgroundHealthcare aides provide the most direct care to residents in long‐term care homes and are uniquely positioned to influence the quality of care. Yet, they are not typically included in team decisions for improving resident care. As demand for long‐term care increases, it is essential that we have a comprehensive understanding of ways to support healthcare aides' role on the interprofessional team for decision‐making about resident care.DesignNarrative review.MethodFive electronic databases were searched for articles published in English between 2008 and 2020. Thematic analysis was conducted to synthesise findings using an organising framework. Reporting followed the PRISMA‐ScR.ResultsTwelve studies were included. Results indicate that work environment factors that influenced (supported or hindered) healthcare aides' involvement in decision‐making included information access/availability, hierarchical staffing structures and supervisor support/shared governance. Relational processes that influenced team decision‐making included team communication and collaboration, information sharing and exchange, and the quality of work relationships among team members. Strategies are discussed that could address the identified barriers and support healthcare aides' active involvement in team decisions regarding resident care.ConclusionsThis review highlights the pervasive underutilization of healthcare aides, who have the most knowledge of residents to support person‐centred care. There remains a paucity of research on healthcare aides' involvement in team decision‐making. Research is needed to examine the effectiveness of interventions to support healthcare aides' participation in decision‐making and the impact on staff and resident outcomes.Relevance to Clinical Practice: It is crucial that healthcare aides are afforded opportunities to be part of the interprofessional team for information sharing and decision‐making for resident care. Managers play a key role in supporting healthcare aides' inclusion in decision‐making.