bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lower Leg Power and Grip Strength Are Associated With Increased Fall Injury Risk in Older Men: The Osteoporotic Fractures in Men Study
Authors: Winger Mary E , Caserotti Paolo , Cauley Jane A , Boudreau Robert M , Piva Sara R , Cawthon Peggy M , Orwoll Eric S , Ensrud Kristine E , Kado Deborah M , Strotmeyer Elsa S ,   Osteoporotic Fractures in Men (MrOS) Research Group, Orwoll E , Lapidus J , Nielson C , Marshall L , Pedersen C , Abrahamson M , Wang Y , Wiedrick J , Fino N , Hooker E , Nava J , Cummings S R , Bauer D C , Black D M , Cawthon P M , Stone K L , Collins R , Black B , Blackwell T , Burghardt A , Concepcion L , Ewing S , Harrison S L , Lui L Y , Majumdar S , Navy C , Parimi N , Patel S , Peters K , Schafer A , Schambach C , Schwartz A , Yu A , Shikany J , Lewis C , Kilgore M , Johnson P , Young M , Webb N , Felder S , Collier C , Hardy K , Ensrud K , Fink H , Diem S , Schousboe J , Taylor B , Langsetmo L , Potter S , Nelson N , Van Coevering P , Jacobson K , Kats A , Luthi S , Moen K , Penland-Miller E , Vo T , Stefanick M , Hoffman A , Ellsworth N , Kent K , Cauley J , Zmuda J , Strotmeyer E , Cusick D , Newman C , Flaugh A , Happe S , Kado D , Barrett-Connor E , Claravall L , Carrion-Petersen M L , Miller P , Stephens M , Smith J 
Published: June 2022

AbstractBackgroundPast research has not investigated both lower-extremity power and upper-extremity strength in the same fall injury study, particularly nonfracture fall injuries.MethodsIn the Osteoporotic Fractures in Men Study (baseline: N = 5 994; age 73.7 ± 5.9 years; 10.2% non-White), fall injuries (yes/no) were assessed prospectively with questionnaires approximately every 3 years over 9 years. Maximum leg power (Watts) from Nottingham single leg press and maximum grip strength (kg) from handheld dynamometry were assessed at baseline and standardized to kg body weight. Physical performance included gait speed (6-m usual; narrow walk) and chair stands speed.ResultsOf men with ≥1/4 follow-ups (N = 5 178; age 73.4 ± 5.7 years), 40.4% (N = 2 090) had ≥1 fall injury. In fully adjusted repeated-measures logistic regressions, lower power/kg and grip strength/kg had higher fall injury risk (trend across quartiles: both p &lt; .0001), with lower quartiles at significantly increased risk versus highest Q4 except for grip strength Q3 versus Q4. Fall injury risk was 19% higher per 1 standard deviation (SD) lower power/kg (95% confidence interval [CI]: 1.12–1.26) and 16% higher per SD lower grip strength/kg (95% CI: 1.10–1.23). In models including both leg power/kg and grip strength/kg, odds ratios (ORs) were similar and independent of each other and physical performance (leg power/kg OR per SD = 1.13, 95% CI: 1.06–1.20; grip strength/kg OR per SD = 1.11, 95% CI: 1.05–1.17).ConclusionsLower leg power/kg and grip strength/kg predicted future fall injury risk in older men independent of physical performance. Leg power potentially identifies fall injury risk better than grip strength at higher muscle function, though grip strength may be more suitable in clinical/practice settings.
Altered hydroxymethylome in the substantia nigra of Parkinson’s disease
Authors: Min Shishi , Xu Qian , Qin Lixia , Li Yujing , Li Ziyi , Chen Chao , Wu Hao , Han Junhai , Zhu Xiongwei , Jin Peng , Tang Beisha 
Published: June 2022

Abstract
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and aging and genetic and environmental exposure can contribute to its pathogenesis. DNA methylation has been suggested to play a pivotal role in neurodevelopment and neurodegenerative diseases. 5-hydroxymethylcytosine (5hmC) is generated through 5-methylcytosine (5mC) oxidization by ten-eleven translocation proteins and is particularly enriched in the brain. Although 5hmC has been linked to multiple neurological disorders, little is known about 5hmC alterations in the substantia nigra of patients with PD. To determine the specific alterations in DNA methylation and hydroxymethylation in PD brain samples, we examined the genome-wide profiles of 5mC and 5hmC in the substantia nigra of patients with PD and Alzheimer’s disease (ad). We identified 4119 differentially hydroxymethylated regions (DhMRs) and no differentially methylated regions (DMRs) in the postmortem brains of patients with PD compared with those of controls. These DhMRs were PD-specific when compared with the results of AD. Gene ontology analysis revealed that several signaling pathways, such as neurogenesis and neuronal differentiation, were significantly enriched in PD DhMRs. KEGG enrichment analysis revealed substantial alterations in multiple signaling pathways, including phospholipase D (PLD), cAMP and Rap1. In addition, using a PD Drosophila model, we found that one of the 5hmC-modulated genes, PLD1, modulated α-synuclein toxicity. Our analysis suggested that 5hmC may act as an independent epigenetic marker and contribute to the pathogenesis of PD.
Introduction to “HaloDaSH: The Deep and Shallow History of Aquatic Life's Passages Between Marine and Freshwater Habitats”
Authors: Schultz Eric T , Park Boush Lisa 
Published: June 2022

Synopsis
This series of papers highlights research into how biological exchanges between salty and freshwater habitats have transformed the biosphere. Life in the ocean and in freshwaters have long been intertwined; multiple major branches of the tree of life originated in the oceans and then adapted to and diversified in freshwaters. Similar exchanges continue to this day, including some species that continually migrate between marine and fresh waters. The series addresses key themes of transitions, transformations, and current threats with a series of questions: When did major colonizations of fresh waters happen? What physiographic changes facilitated transitions? What organismal characteristics facilitate colonization? Once a lineage has colonized freshwater, how frequently is there a return to the sea? Have transitions impelled diversification? How do organisms adapt physiologically to changes in halohabitat, and are such adaptive changes predictable? How do marine and freshwater taxa differ in morphology? How are present-day global changes in the environment influencing halohabitat and how are organisms contending with them? The purpose of the symposium and the papers in this volume is to integrate findings at multiple levels of biological organization and from disparate fields, across biological and geoscience disciplines.
Making Space for Creativity: Niche Construction and the Artist’s Studio
Authors: Saarinen Jussi A , Krueger Joel 
Published: June 2022

Abstract
It is increasingly acknowledged that creativity cannot be fully understood without considering the setting where it takes place. Building on this premise, we use the concepts of niche construction, scaffolding, coupling, and functional integration to expound on the environmentally situated nature of painters’ studio work. Our analysis shows studios to be multi-resource niches that are customized by artists to support various capacities, states, and actions crucial to painting. When at work in these personalized spaces, painters do not need to rely solely on their “inner” powers of imagination, memory, decision making, and technique to execute their paintings. Instead, with the help of carefully selected resources, they can offload elements of creative mentation and action onto the studio niche and enact different forms of a creative agency. To put more flesh on these ideas, we examine how painters use (1) existing artworks, (2) memory aids, and (3) music to scaffold the creative process. Overall, our analysis illuminates underexamined aspects of environmentally situated creativity and demonstrates the broader utility of the applied concepts for future creativity research.
Outbreak of Carbapenemase-Producing Enterobacteriaceae in a Regional Burn Center
Authors: Rehou Sarah , Rotman Sydney , Avaness Melisa , Salt Natasha , Jeschke Marc G , Shahrokhi Shahriar 
Published: June 2022

Abstract
Antimicrobial resistance is an increasing problem in hospitals worldwide; however, the prevalence of carbapenemase-producing Enterobacteriaceae (CPE) in our region is low. Burn patients are vulnerable to infection because of the loss of the protective skin barrier, thus burn centers prioritize infection prevention and control (IP&C). This report describes a CPE outbreak in a regional burn center. In a period of 2.5 months, four nosocomial cases of CPE were identified, three containing the Klebsiella pneumoniae carbapenemase (KPC) gene and one Verona integrin-encoded metallo-β-lactamase (VIM) gene. The first two cases were identified while there was no CPE patient source on the unit. CPE KPC gene was then isolated in sink drains of three rooms. In addition to rigorous IP&C practices already in place, we implemented additional outbreak measures including restricting admissions to patients with complex burns or burns ≥10% TBSA, admitting patients to other in-patient units, and not permitting elective admissions. We began cohorting patients using nursing team separation for CPE-positive and -negative patients and geographical separation on the unit. Despite aggressive IP&C measures already in place, hospital-acquired CPE colonization/infection occurred. Given that CPE contaminated sinks of the same enzyme were identified, we believe hospital sink drains may the source. This highlights the importance of sink design and engineering solutions to prevent the formation of biofilm and reduce splashing. CPE infections are associated with poor outcomes in patients and significant health system costs due to a longer length of stay and additional institutional resources.
Appraisal of clinicopathological prognosticators in advanced acral lentiginous melanoma with characterization of PD-L1 and CD8/CD4 immunoprofiles
Authors: Chuang I-Chieh , Jang Chiau-Sheng 
Published: June 2022

Abstract

Objective
Acral lentiginous melanoma is the most common subtype of cutaneous melanoma in Asian countries. This study aims to clarify the associations between certain histologic and immunohistochemical parameters, and identify their prognostic values.

Methods
We assessed several histologic features and conducted immunohistochemical study of programmed cell death ligand 1 (clone 22C3) and CD8/CD4 in 61 Taiwanese patients with Stage III/IV, non-BRAF acral lentiginous melanomas.

Results
A total of 41 males and 20 females were included, with a median age of 74 years. The majority of tumors occurred at nonungual locations (86.9%), with ‘foot’ being the most frequently affected site (85.2%). Positive programmed cell death ligand 1 staining (combined positive score ≥ 10) was significantly associated with the status of tumor-infiltrating lymphocytes (P = 0.036). Lack of skin ulceration was linked to the immunoexpression of CD8/CD4-high (P = 0.004). A superior clinical outcome was found in the tumor-infiltrating lymphocytes-present group (P = 0.011), and among which, CD8/CD4-high was significantly correlated with better survival (P &lt; 0.001). Combined survival analysis revealed that the PD-L1(−) TIL(+) CD8/CD4-high subgroup was associated with favorable prognosis, and cases with PD-L1(+) TIL(−) showed the worst disease specific survival (P &lt; 0.001). In the univariate analysis, lymphovascular invasion (P = 0.002), skin ulceration (P = 0.002), tumor-infiltrating lymphocytes (P = 0.015) and CD8/CD4 status (P &lt; 0.001) were significant prognostic factors. At the multivariate level, the statuses of CD8/CD4-low (P &lt; 0.001) and lymphovascular invasion (P = 0.014) represented the independent poor prognosticators.

Conclusion
For advanced, non-BRAF acral lentiginous melanomas, comprehensive assessments of these microscopic traits, along with CD8/CD4 and PD-L1 immunoprofiles, may help guide the clinicians and patients through treatment decisions.
Relevance of Spatial and Temporal Trends in Nymphal Tick Density and Infection Prevalence for Public Health and Surveillance Practice in Long-Term Endemic Areas: A Case Study in Monmouth County, NJ
Authors: Jordan Robert A , Gable Sydney , Egizi Andrea 
Published: June 2022

Abstract
Tick-borne diseases are a growing public health problem in the United States, and the US northeast has reported consistently high case rates for decades. Monmouth County, New Jersey, was one of the earliest jurisdictions to report Lyme disease cases in 1979 and reports several hundred cases per year nearly 40 yr later. In the time since, however, tick-borne health risks have expanded far beyond Lyme disease to include a variety of other bacterial pathogens and viruses, and additional vectors, necessitating a continually evolving approach to tick surveillance. In 2017, Monmouth County initiated an active surveillance program targeting sites across three ecological regions for collection of Ixodes scapularis Say (Acari: Ixodidae) and Amblyomma americanum L. (Acari: Ixodidae) as well as testing via qPCR for associated bacterial pathogens. During the first five years of this program (2017–2021), we report high levels of spatiotemporal variability in nymphal density and infection prevalence in both species, limiting the granularity with which human risk can be predicted from acarological data. Nonetheless, broader patterns emerged, including an ongoing trend of A. americanum dominance, risks posed by Borrelia miyamotoi, and the frequency of coinfected ticks. We present some of the first county-level, systematic surveillance of nymphal A. americanum density and infection prevalence in the northeastern US. We also documented a temporary decline in Borrelia burgdorferi that could relate to unmeasured trends in reservoir host populations. We discuss the implications of our findings for tick-borne disease ecology, public health communication, and tick surveillance strategies in endemic areas.
Israeli Parents’ Lived Experiences of Music Therapy With Their Preterm Infants Post-Hospitalization
Authors: Epstein Shulamit , Elefant Cochavit , Ghetti Claire 
Published: June 2022

Abstract
In the current study, we aimed to explore the lived experience of Israeli parents who engaged in musical dialogues with their preterm infants during music therapy (MT) after being discharged from the neonatal intensive care unit (NICU), as a part of the multinational LongSTEP RCT. Seven participants of the main trial were invited to engage in semi-structured in-depth interviews intertwining listening to audio recordings from their music therapy sessions in an adapted interpersonal process recall (IPR) procedure. The interviews were transcribed and analyzed using interpretative phenomenological analysis (IPA). We understood the participants’ experiences to reflect two main themes: 1) Music therapy as a potential means of transformation in communication skills, resourcefulness and sense of agency; and 2) emotional and musical preconditions for parental engagement in MT. The findings illustrate how a specific group of Israeli parents experienced MT as offering them a means of expanding their relationship with their preterm infants after discharge. Based on our findings, we recommend that music therapists consider parents’ musical and emotional resources during post-discharge MT to meet the individual needs of families.
Effect of medical treatments in disseminated peritoneal leiomyomatosis: a case report
Authors: Navarro Anne-Sophie , Angeles Martina Aida , Illac Claire , Boulet Bérénice , Ferron Gwenael , Martinez Alejandra 
Published: June 2022

Abstract
Disseminated peritoneal leiomyomatosis (DPL) is a rare gynecologic disease involving multifocal proliferation of myomas. The pathogenesis remains unclear. Although there is no standard treatment, medical therapies have attempted to suppress estrogen levels by using gonadotrophin-releasing hormone agonist and aromatase inhibitor (AI) therapy with differing degrees of success. Surgery is also an option in symptomatic patients, and in the event of partial or no response to medical treatments. We report a case of DPL in a young woman with a previous history of myomectomy. She was treated sequentially with ulipristal acetate and AI.
‘Medical Popes’ and ‘Vaccination Protestants’: Anti-Catholicism and the Campaign against Compulsory Vaccination in Victorian England
Authors: Cottrell-Boyce Aidan 
Published: June 2022

Abstract
The anti-vaccination campaign of the late nineteenth century has attracted the attention of historians in recent decades. The campaign against compulsory vaccination for smallpox gained the support of hundreds of thousands of people in Victorian Britain. Many objected to vaccination on scriptural grounds. Many others claimed that it was contradictory to their belief in mesmerism, Swedenborgianism or hydropathy. Still others argued that the Vaccination Acts of 1867 and 1871 represented a violation of individual liberties. One overlooked aspect of this movement relates to the use of anti-Catholic rhetoric in the speeches and literature which its leaders produced. A significant proportion of these leaders were drawn from the community of medical dissent. These individuals lived through a period when anti-Catholicism began to wane as a political force in England. Confronted with the new phenomenon of medical professionalization, they sought to style themselves as the inheritors of a Protestant tradition. In doing so, this article suggests that they attempted to repurpose the frailties of their movement – its reputation as crankish, plebeian or marginal – as strengths, and the avowed expertise of medical professionals as a weakness.
The transcription factor OsGATA6 regulates rice heading date and grain number per panicle
Authors: Zhang Yan-Jie , Zhang Yu , Zhang Liang-Li , He Jun-Xian , Xue Hong-Wei , Wang Jia-Wei , Lin Wen-Hui 
Published: June 2022

Abstract
Heading date, panicle architecture, and grain size are key traits that affect the yield of rice (Oryza sativa). Here, we identified a new gene, OsGATA6, whose product regulates heading date. Overexpression of OsGATA6 resulted in delayed heading, increased grain number, and decreased grain size. Knockdown lines generated by artificial microRNA (amiRNA) and CRISPR genome-edited lines of OsGATA6 both showed earlier heading, decreased grain number, and increased grain size. These results suggested that OsGATA6 negatively regulates heading date, positively regulates panicle development, and affects grain size. OsGATA6 was found to be constitutively expressed in rice, and strongly expressed in young leaves and panicles. In situ hybridization analyses showed that OsGATA6 was specifically localized in superficial cells of the panicle primordium. Overexpression lines show decreased expression of RFT1 and Hd3a, which promote heading. OsMFT1, which delays heading date and increases grain number, was down-regulated in amiRNA lines. Further analyses showed that OsGATA6 could bind to the promoter of OsMFT1 and induce its expression, thereby regulating heading date and panicle development. Overexpression of OsGATA6 in Arabidopsis resulted in repressed expression of AtFT and late flowering, suggesting that its function is similar. Taken together, we have identified a new GATA regulator that influences rice heading date and grain number, which potentially increases rice yield.
Altered collective mitochondrial dynamics in the Arabidopsismsh1mutant compromising organelle DNA maintenance
Authors: Chustecki Joanna M , Etherington Ross D , Gibbs Daniel J , Johnston Iain G 
Published: June 2022

AbstractMitochondria form highly dynamic populations in the cells of plants (and almost all eukaryotes). The characteristics and benefits of this collective behaviour, and how it is influenced by nuclear features, remain to be fully elucidated. Here, we use a recently developed quantitative approach to reveal and analyse the physical and collective ‘social’ dynamics of mitochondria in an Arabidopsis msh1 mutant where the organelle DNA maintenance machinery is compromised. We use a newly created line combining the msh1 mutant with mitochondrially targeted green fluorescent protein (GFP), and characterize mitochondrial dynamics with a combination of single-cell time-lapse microscopy, computational tracking, and network analysis. The collective physical behaviour of msh1 mitochondria is altered from that of the wild type in several ways: mitochondria become less evenly spread, and networks of inter-mitochondrial encounters become more connected, with greater potential efficiency for inter-organelle exchange—reflecting a potential compensatory mechanism for the genetic challenge to the mitochondrial DNA population, supporting more inter-organelle exchange. We find that these changes are similar to those observed in friendly, where mitochondrial dynamics are altered by a physical perturbation, suggesting that this shift to higher connectivity may reflect a general response to mitochondrial challenges, where physical dynamics of mitochondria may be altered to control the genetic structure of the mtDNA population.
Search for extended Lyman-α emission around 9k quasars at z = 2–3
Authors: Shimakawa Rhythm 
Published: June 2022

ABSTRACT
Enormous Lyα nebulae (ELANe) around quasars have provided unique insights into the formation of massive galaxies and their associations with super-massive black holes since their discovery. However, their detection remains highly limited. This paper introduces a systematic search for extended Lyα emission around 8683 quasars at z = 2.34–3.00 using a simple but very effective broad-band gri selection based on the Third Public Data Release of the Hyper Suprime-Cam Subaru Strategic Program. Although the broad-band selection detects only bright Lyα emission (≳ 1 × 10−17 erg s−1cm−2 arcsec−2) compared with narrow-band imaging and integral field spectroscopy, we can apply this method to far more sources than such common approaches. We first generated continuum g-band images without contributions from Lyα emission for host and satellite galaxies using r- and i-bands. Then, we established Lyα maps by subtracting them from observed g-band images with Lyα emissions. Consequently, we discovered extended Lyα emission (with masked area &gt;40 arcsec2) for 7 and 32 out of 366 and 8317 quasars in the Deep and Ultra-deep (35 deg2) and Wide (890 deg2) layers, parts of which may be potential candidates of ELANe. However, none of them seem to be equivalent to the largest ELANe ever found. We detected higher fractions of quasars with large nebulae around more luminous or radio-loud quasars, supporting previous results. Future applications to the forthcoming big data from the Vera C. Rubin Observatory will help us detect more promising candidates. The source catalogue and obtained Lyα properties for all the quasar targets are accessible as online material.