bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Outcomes of Dual Trigger With Combination GnRH Agonist and hCG Versus Single Trigger With hCG Alone in Women Undergoing IVF/ICSI Cycles: a Retrospective Cohort Study With Propensity Score Matching
Authors: Dong Li , Lian Fang , Wu Haicui , Xiang Shan , Li Yuan , Wei Chaofeng , Yu Xiaona , Xin Xin 
Published: January 2022

Abstract
Background: Despite a large number of studies on the selection of trigger drugs, it remains unclear whether the dual trigger with human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone (GnRH) agonist, compared to the single trigger with hCG alone, can improve the clinical outcome of patients undergoing assisted reproductive technology. Therefore, this study aimed to compare the laboratory and clinical outcomes of dual trigger versus single trigger.Methods: In this retrospective cohort study, we evaluated 520 in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles between July 2014 and September 2020 at the Reproductive and Genetic Center of Integrative Medicine, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine. All patients underwent IVF/ICSI treatment with fresh embryo transfer using the GnRH antagonist protocol. We used propensity score matching to control for confounding variables and binary logistic regression analysis to determine the correlations between trigger methods and pregnancy outcomes. After propensity score matching, 57 cycles from each group were evaluated and compared for laboratory or clinical outcomes in this retrospective cohort study. Results: There was no significant difference in the number of oocytes retrieved, embryos available, top-quality embryos, or the rate of normal fertilization between the dual-trigger and single-trigger protocols, respectively. The implantation rate, clinical pregnancy rate, ectopic pregnancy rate, and live birth rate were also similar between the two groups, while the miscarriage rate (37.0% vs. 12.5%, p=0.045) was notably higher in the dual-trigger than the single-trigger group. Subsequent binary logistic regression analysis showed that age was a remarkably significant independent predictor of both clinical pregnancy rate (odds ratio=0.90, 95% confidence interval: 0.84–0.97, p=0.006) and live birth rate (odds ratio =0.89, 95% confidence interval: 0.82–0.97, p=0.005). Conclusions: Therefore, dual-trigger for final oocyte maturation might increase miscarriage rate, but in terms of the laboratory and other pregnancy outcomes such as clinical pregnancy rate or live birth rate, there was no evidence to show that dual trigger was superior to an hCG-trigger alone for patients undergoing GnRH-antagonist cycles with fresh embryo transfer. Trial registration: Retrospectively registered.
Magnetic phase diagram of the solid solution LaMn2(Ge1-xSix)2 (0 ≤ x ≤ 1) unraveled by powder neutron diffraction
Authors: Mudring Anja-Verena , Siebeneichler Stefanie , Ovchinnikov Alexander , Bosch-Santos Brianna , Cabrera-Pasca Gabriel A. , Flacau Roxana , Huang Qingzhen , Carbonari Artur W. , Ryan Dominic 
Published: January 2022

Abstract
The structural and magnetic properties of the ThCr2Si2-type solid solution LaMn2(Ge1−xSix)2 (x = 0.0 to 1.0) have been investigated employing a combination of X-ray diffraction, magnetization and neutron diffraction measurements, which allowed establishing a magnetic composition-temperature phase diagram. Substitution of Ge by Si leads to a compression of the unit cell, which affects the magnetic exchange interactions. In particular, the magnetic structure of LaMn2(Ge1−xSix)2 is strongly affected by the unit cell parameter c, related to the separation of adjacent Mn layers. Commensurate antiferromagnetic layers and a canted ferromagnetic structure dominate the Si-rich part of the solid solution, whilst an incommensurate antiferromagnetic flat spiral and a conical magnetic structure are observed in the Si-poor part.
Relative Equilibrium and Stability of a Three-body Tethered Satellite in an Elliptical Orbit
Authors: Zhong Xue , Zhao Jie , Yu Kaiping , Xu Minqiang 
Published: January 2022

Abstract
This work focuses primarily on the relative equilibrium and stability of a three-body tethered satellite which center of mass moves along an elliptical orbit with arbitrary eccentricity in the central Newtonian field. We only consider the case with straight tethers, and the lengths of them are small compared to the size of the orbit. It means that the attitude motion of the satellite has no impact on its orbital motion. Additionally, it assumes that the lengths of the tethers are controllable. The law of the tether length control is determined on the basis of the dynamical model of the system so that there exists an Earth-pointing relative equilibrium of the tethered satellite. By analyzing the Floquet multipliers of the linearized system, Lyapunov instability regions and linear stability regions of the relative equilibrium are obtained in a plane of dimensionless parameters. Further nonlinear stability analysis is presented in the linear stability regions by means of a normal form technique and stability theorems on the Hamiltonian system. In particular, stability of nonresonant cases as well as fourth-order resonant cases are investigated in detail.
Caveolar Disruption with Methyl-β-Cyclodextrin Causes Endothelium-Dependent Contractions in Wistar Rat Carotid Arteries
Authors: Albrakati Ashraf 
Published: January 2022

Abstract
Caveolae are organizing centers for cellular signal transduction in endothelial cells (ED) and smooth muscle cells (SMCs) in the blood vessels. Methods: Myography was used to investigate effects of caveolar disruption using methyl-β-cyclodextrin (MBCD) on maxi-K channels in rat carotid arteries. Results: Incubation of carotid segments with MBCD augmented contractions in response to BaK (chemical channel agonist) but not those induced by depolarizing high potassium physiological saline (KPSS). In contrast, incubation with cholesterol-saturated MBCD (Ch-MBCD) abolished the effects of MBCD. Mechanical removal of endothelial cells by MBCD triggered a small contraction in response to BaK. Incubation with nitroarginine methyl ester (L-NAME) inhibited nitric oxide (NO) release, thereby causing increased contractions in response to BaK, and this effect was reversed by pretreatment with MBCD. These results suggest that MBCD inhibits endothelial NO release. Contrastingly, inhibition of maxi-K channels with iberiotoxin enhanced contractions in response to BaK. Likewise, L-NAME decreased the contractile effect of iberiotoxin, as in the ED-denuded arteries. Transmission electron microscopy (TEM) showed the presence and absence of caveolae in intact blood vessels before and after MBCD treatment, respectively, whereas histology confirmed ED removal after the treatment. Conclusions: Caveolar disrupted using MBCD impairs ED-dependent relaxation by inhibiting the release of NO from the ED and altered the contractility of SMCs independent of the ED due to reduced contribution of maxi-K channels to the SMC membrane potential, causing depolarization and increasing carotid artery contraction. These findings might help to understand physiological role of the maxi-K channels in rat carotid arteries.
Management and long-term outcomes of acute right colonic diverticulitis and risk factors of recurrence
Authors: Chen Ji , Ma Zhilong , Zhou Jia , Liu Weiwei , Yao Le , Xie Wangcheng , Su Mingqi , Yang Jin , Shao Jun 
Published: January 2022

Abstract
Background: Acute right-sided colonic diverticulitis (RCD) is a common disease in Asian populations for which the optimal treatment remains controversial. The aim of this study was to investigate management and evaluate long-term outcomes of treatment in patients with acute RCD. Methods: We retrospectively collected and analyzed clinical data for patients with acute RCD admitted to the Tongren Hospital, Shanghai Jiao Tong University School of Medicine from December 2015 to December 2020. The patients were divided into two groups, according to primary treatment strategy, which was either conservative treatment or surgical treatment. Results: A total of 162 consecutive patients with acute RCD were enrolled in the study. There was no significant difference in age, sex, history of abdominal surgery, medical co-morbidities, fever, previous history of RCD, treatment success rate and incidence of complications between the conservative and surgery groups. However, the recurrence rate in conservative groups was significantly higher than in surgery groups (16.53% vs 2.44%, P = 0.020). And more frequent bowel movements and previous history of RCD increased the risk of recurrence of acute RCD. Moreover, there was no significant difference in either treatment success rate or the overall recurrence rate between the patients with uncomplicated diverticulitis and patients with complicated diverticulitis. Conclusions: Surgical treatment is also safe and effective for acute RCD. Surgical treatment should mainly be considered for patients with acute RCD with recurrence risk factors (more frequent bowel movements and previous history of RCD) or with complicated acute RCD.
Drug Components-Disease Network Related to Acute Lung Injury Inference Based on Forest Graph-embedded Deep Feedforward Network
Authors: Yang Bin , Bao Wenzheng , Wang Jinglong , Chen Baitong 
Published: January 2022

Abstract
Background: Acute lung injury (ALI) is a serious respiratory disease, which can lead to acute respiratory failure or death. It is closely related to the pathogenesis of New Coronavirus pneumonia (COVID-19). Many researches showed that traditional Chinese medicine (TCM) had a good effect on its intervention, and network pharmacology could play a very important role. Results: In order to construct "disease-gene-target-drug" interaction network more accurately, deep learning algorithm is utilized in this paper. Two ALI-related target genes (REAL and SATA3) are considered, and the active and inactive compounds of the two corresponding target genes are collected as training data, respectively. Molecular descriptors and molecular fingerprints are utilized to characterize each compound. Forest graph embedded deep feed forward network (forgeNet) is proposed to train and identify 19 compounds in Erhuang decoction (EhD) and Dexamethasone (DXMS).Conclusions: The experiment results show that forgeNet performs better than support vector machines (SVM), random forest (RF) and gcForest.
Vascular and Neuronal Effects of General Anesthesia on Functional Magnetic Resonance Imaging
Authors: Vedaei Faezeh , Alizadeh Mahdi , Tantawi Mohamed , Romo Victor M , Mohamed Feroze B. , Wu Chengyuan 
Published: January 2022

Abstract
A number of functional magnetic resonance imaging (fMRI) studies rely on application of anesthetic agents that can modulate and complicate interpretation of the measured hemodynamic blood oxygenation level-dependent (BOLD) response. The purpose of this study was to investigate the effect of general anesthesia on two main components of BOLD signal including neuronal activity and vascular response. Breath-holding (BH) fMRI was conducted in wakefulness and under anesthesia states in patients with drug resistant epilepsy (DRE) who needed to get scanned under anesthesia during laser interstitial thermal therapy (LITT). BOLD and BOLD-cerebrovascular reactivity (BOLD-CVR) maps were compared between two states to assess the effect of anesthesia on neuronal activity and vascular factors. Overall, our findings revealed an increase in BOLD-CVR and decrease in BOLD response under anesthesia. The results proposed that the modulatory mechanism of anesthetics on neuronal and vascular components of BOLD signal may work in different ways. To our knowledge, this is the first human study to examine the effect of general anesthesia using BH fMRI imaging, enhancing our understanding of the effect of anesthesia on neuronal and vascular aspects of BOLD response and assisting the implication of general anesthesia and interpretation of outcomes in clinical setting.
Evaluation of fertility, hatchability and egg quality of indigenous chicken at different agro-ecologies of Sidama Region, Ethiopia
Authors: Tunsisa Legesse Yotona , Berihun Kefyalew 
Published: January 2022

Abstract
Poultry is one of the most important subsectors of livestock, supplying a cheap source of good quality animal protein in the form of meat and eggs. This study was conducted to assess egg fertility, hatchability and egg quality parameters of indigenous chickens in the Hulla, Aleta Wondo and Dale districts, representing highland, midland and lowland agroecologies, respectively. Six kebeles (two kebeles from each district) were purposively selected based on a lower distribution of exotic chickens. A total of 750 eggs of indigenous chicken were collected from three different agro-ecologies, 450 eggs were used for fertility and hatchability evaluation, and 300 eggs were used for internal and external quality analysis. The collected data were analyzed using SPSS version 20 and SAS version 9.0 packages. The results indicated that agroecology has no significant effect on the fertility and hatchability of indigenous chicken eggs. The values of egg weight, egg length, shell weight, yolk weight, and yolk diameter and albumen weight of eggs collected from midland were higher than those of eggs from highland and lowland areas. However, the highest values for albumen height, yolk height and Haugh unit were observed on eggs collected from highland agroecology. In conclusion, agroecology has no effect on the fertility and hatchability of indigenous chicken eggs. However, agroecology significantly affects the internal and external egg quality of indigenous chicken eggs. Therefore, the storage condition and duration of storage need consideration to maintain the external quality of eggs.
A case of hypertensive nephropathy who died of piperacillin- tazobactam induced immune hemolytic anemia which aggravated renal dysfunction: complete follow-up of serology and disease course
Authors: Wu Yuanjun , Wu Yong , Guo Ganping , Zeng Jiajun , Liu Yan , Wu Yueqin 
Published: January 2022

Abstract
Background: Severe drug-induced immune hemolytic anaemia (DIIHA) cases leading to death are very rare. Among the reported cases of DIIHA, the serological characteristics and course of the disease are rarely described completely. Piperacillin is a semi-synthetic penicillin against pseudomonas widely used in the treatment of bacterial infections. It is one of the most common drugs that cause DIIHA. Methods: In this study, a 79-year-old male patient with hypertensive nephropathy who developed severe hemolytic anemia during intravenous piperacillin-tazobactam anti-infective treatment due to lung infection, and worsened renal function. Serological tests included direct antiglobulin test (DAT), acid elution test, irregular red blood cell (RBC) antibody detection, and the drug-dependent antibodies associated with piperacillin or tazobactam were detected by the standard methods for the detection of drug-dependent antibodies both in the presence of soluble drug and with drug-coated RBCs. Fully described the patient's course of disease and the serological changes after stopping the administration of piperacillin-tazobactam.Results: Serological tests showed that the results of DAT for anti-IgG was positive (4+) and anti-C3d was negative. The IgG piperacillin-dependent antibodies (the highest titer reached 128) were detected in the plasma incubated with O-type RBCs and 3 mg/mL piperacillin. But the plasma or the acid eluent incubated with piperacillin-coated RBCs, or the acid eluent incubated with O-type RBCs and 3 mg/mL piperacillin did not detect antibodies. The patient was diagnosed as piperacillin-induced DIIHA. Although blood transfusion and continuous renal replacement therapy were given, the patient still died of multiple organ failure 15 days after the administration of piperacillin-tazobactam was stopped.Conclusions: DIIHA caused by piperacillin exacerbated renal damage and was an important cause of the patient's eventual death from multiple organ failure. Which has helped to deepen the understanding of DIIHA and draw lessons from it.
GW-2974 and SCH-442416 modulators of tyrosine-kinase and adenosine receptors can also stabilize human telomeric G-quadruplex DNA: Insights into their anticancer effect
Authors: Salem Alaa A. , Haty Ismail El , Ghattas Mohammad A 
Published: January 2022

Abstract
GW-2974 is a potent inhibitor for the tyrosine kinase receptor. It inhibits EGFR and ErbB-2 in tumor cells with high selectivity towards malignant over normal cells. SCH-442416 is a potent antagonist for adenosine receptor with high selectivity towards human A2a receptor over other adenosine receptors. The two compounds were reported to possess antitumor properties. In this work, we studied the stabilization of human telomeric G-quadruplex DNA by GW-2974 and SCH-442416, as a probable underlying mechanism for their anticancer effects. Interactions of human telomeric G-quadruplex DNA - sequence AG3(TTAGGG)3 – with both compounds were studied using UV-Vis, fluorescence quenching, melting temperature, circular dichroism and molecular docking techniques. Results obtained from absorption, fluorescence and CD indicated that GW2974 and SCH-442416 interacted with G-quadruplex through intercalation binding modes on two types of dependent binding sites. Binding affinities of 1.3x108 - 1.72x106 M-1 and of 1.55x107 - 3.74x105 M-1 were respectively obtained for GW-2974 for SCH-442416. An average number of binding sites between 1 and 2 was obtained for both compounds. The melting temperature curves indicated that complexations of both compounds to G-quadruplex DNA have respectively stabilized it by ΔTm = 9.9 oC and 9.6 oC, relative non-complexed G-quadruplex DNA. Increasing the molar ratios of GW-2974 or SCH-442416 relative to G-quadruplex DNA over 1:1 has shown to destabilized G-quadruplex DNA. Our selectivity experiment indicated 4.7- and 4.0-folds better selectivity for GW-2974 and SCH-442516 towards G-quadruplex DNA over ds-DNA, respectively. The two compounds have also proved to selectively bind and stabilize G-quadruplex DNA over calf thymus duplex ct-DNA. In silico molecular docking indicated exothermic intercalation bindings on two sites of the G-quadruplex DNA These results supported our hypothesis that both GW-2974 and SCH-442416 strongly stabilize human telomeric G-quadruplex DNA in additions to modulating tyrosine-kinase and adenosine receptors. Consequently, stabilizing G-quadruplex DNA could contribute to the mechanism of their anticancer activity.
ArticleInsulin resistance and cardiometabolic indexes: a comparison of gender-related differences in working-age subjects with overweight and obesity
Authors: Vigna Luisella , Tirelli Amedea Silvia , Gaggini Melania , Piazza Salvina Di , Tomaino Laura , Turolo Stefano , Moroncini Gianluca , Chatzianagnostou Kyriazoula , Bamonti Fabrizia , Vassalle Cristina 
Published: January 2022

Abstract
Purpose: The aim of the study was to evaluate indexes of insulin resistance and cardiometabolic risk in a large population of workers with overweight or obesity, evidencing possible gender-related differences, in order to identify a possible efficient, cheap and simple strategy to apply in clinical practice of workers surveillance. Methods: The evaluation of IR and cardiometabolic risk indexes (HOMA, QUICKI, Ty/HDLC, TyG, insuTAG Castelli risk indexes 1 and 2, non-HDLC, TRL-C, AIP, and VAI) was performed in a population of 1195 working-age subjects with overweight or obesity (322 males, mean age 49±11 years). Results: The prevalence of all IR and cardiometabolic risk was higher among males for all indices.Aging, waist circumference, BMI, blood pressure, glucose, CRP, fibrinogen and uric acid were correlated more frequently with IR/cardiometabolic indexes in women, homocysteine in men. The percent of the workers identified as insulin resistant, IR+, or at higher cardiometabolic risk greatly vary according to the different index used.atly varied according to the different index used to measure risk. Conclusion: With a small group of biomarkers and anthropometric measures (fasting glucose and insulin, lipid profile, BMI and waist circumference) is possible to calculate a number of IR/cardiometabolic indexes, which likely mirror different pathophysiological aspects helping in a personalized evaluation of IR and cardiometabolic risk.
Introduction of Advanced Practice Physiotherapy in Dutch Primary Care is a Search for Possibilities, Added Value, and Mutual Trust; A Qualitative Study Among Advanced Practice Physiotherapist and General Practitioners.
Authors: Pellekooren Sylvia , Donker Marianne , Reijnders Eddy , Msc Lamyae Boutalab , Ostelo Raymond , Tulder Maurits , Pool-Goudzwaard Annelies 
Published: January 2022

Abstract
Background: Despite the increasing deployment and added value of Advanced Practitioner in Physiotherapy (APP) in musculoskeletal care internationally, APP is not widely accepted in Dutch primary care yet. This may be due to constraints in the implementation of APP within the Dutch health care system. The aim of this study was to explore experiences and perceptions of APP and General Practitioners (GP) in implementing APP in Dutch primary care. Methods: This was an explorative and interpretive qualitative study among 13 APPs and 3 GPs that were in various stages of implementing an APP care model. Semi-structured interviews were conducted from January to March 2021. The topic list was based on existing literature, personal input of researchers, and the Constellation Approach framework. Data were analysed using a thematic inductive approach.Results: Four main themes emerged from the data; 1) The start-up of an APP practice requires trust and clear added value for the GP, 2) Starting APP must be strongly supported by GP, 3) Positioning of APP is still unclear, and 4) Ownership of patients with musculoskeletal complaints. These four themes put forward perceived difficulties in gaining trust, lack of clarity regarding the added value of APP, ambiguity of the APP’s professional profile and positioning, lack of reimbursement structure, and APP’s struggle in seeking balance with current care. Conclusion: This study shows that the implementation of an APP model of care is challenging. The deployment of APP does not sufficiently align with the core values of GPs, and GPs seem reluctant to hand-over some control over patient care to APPs. APP does not appear to have ownership of the implementation, given its strong dependence on the practice, values and needs of the GP.Trial registration: Ethical approval is obtained from the Medical Ethics Committee of the VU University Medical Centre in Amsterdam; reference number 2020.17. All participants were asked written informed consent before participating in this study.