bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the Evaluation of the Competitiveness of the Container Multimodal Port Hub
Authors: Wan Min , Kuang Haibo , Yu Yue 
Published: May 2022

Abstract
The research on the competitiveness of container multimodal transport port hub, comprehensively considering the software and hardware strength of port hub, is of great significance to analyze the competitiveness of specific goods sources of port hub. Based on this, this paper adopts a multi-attribute decision-making modeling method to construct a port hub competitiveness evaluation model from four aspects: business capabilities, capacity resources, infrastructure, and service quality, and conducts empirical research on container transportation in Northeast China as an example. Studies have shown that the key factors affecting the competitiveness of multimodal port hubs have changed from traditional infrastructure factors to flexible factors such as transportation service quality, transportation capacity resource integration capabilities, and transportation business efficiency. Strengthening inter-industry integration will promote the core competitiveness of port hubs. Formation has obvious effects. The research results have enriched the theoretical system of multimodal transport port hub competitiveness research, and provided reference suggestions for port companies, government authorities and other relevant entities in strategic formulation and policy planning.
The impacts of different cellulosic nanofibers on the handleability and mechanical properties of calcium phosphate silicate cement for bone tissue engineering
Authors: Gong Tianxing , Ji Xiujuan , Liu Xinyu , Zhou Jingqiu , Zhang Jingshu , Chen Yadong , Wu Qiong 
Published: May 2022

Abstract
Aging-related abnormal bone metabolism can have detrimental effects on bone microstructure and significantly increases fracture occurrence in the older population. Injectable bone cement has been commonly used to augment porous and fragile bones. Recently, the self-setting calcium phosphate silicate cement (CPSC) has been proven suitable for bone tissue engineering. Unfortunately, the inadequate mechanical properties of CPSC limit its utilization as implants for load-bearing applications. One primary purpose of this study is to improve the mechanical properties of CPSC using different cellulosic nanofibers. It is shown that the mechanical properties of CPSC could be enhanced by adding 2% mass fractions of CNF, CNF-C and CNF-SH, and the reinforcing effects could be ranked as CNF-SH > CNF > CNF-C. In addition, the Young’s modulus of the CPSC pellet modified with CNF-SH (~ 10 GPa) was proved to be close to that of trabecular bone (~ 11.4 GPa). Unlike other studies, where the mechanical properties of bone cement were improved at the cost of decreasing handleability, our approach could increase both qualities of the CPSC paste at the same time. Furthermore, the in vitro biocompatibility analyses proved that the nanofiber-modified CPSC was biocompatible and encouraged the proliferation and differentiation of osteoblast cells. In summary, the injectable CPSC bone cement can be better enhanced by CNF-SH than CNF or CNF-C, and the resultant nanofiber-reinforced bone cement is a promising candidate for bone tissue engineering.
Analysis and Design of Microstrip Patch Antenna on Photonic Band Gap (PBG) Substrate at Terahertz Regime
Authors: Shamim S. M. , Arafin Nahid , Dina Umme Salma , Shemu Sumaiya , Karim Rezaul 
Published: May 2022

Abstract
For future wireless communication, low-cost, low profile, minimal weight and high performance antenna is required to support high-speed data transmission. This paper presents a graphene based wideband microstrip patch antenna at 1.10THz resonate frequency. Graphene has been used in the proposed antenna for higher electrical conductivity, mobility, and saturation severity in THz band regime. The proposed antenna is mounted on silicon substrate that employed Photonic Band Gap (PBG) having a dielectric constant of 11.9. The outcome of this work has been described in terms of return loss (S11), gain, directivity, voltage standing wave ratio (VSWR) and radiation pattern for both E-plane and H-plane. The proposed antenna has minimal return loss − 48.95dB, gain 3.96dB, VSWR 1.054 and impedance bandwidth 26% which may be an excellent candidate for wireless communication as well as explosive detection, material characterization, medical imaging, homeland defense system etc. All the design and simulations of the proposed antenna has been performed by using commercially available electromagnetic software CST Microwave Studio.
Live birth rate following frozen-thawed blastocyst transfer is higher in high-grade Day 6 blastocyst than low-grade Day 5 blastocyst
Authors: Shi Wenhao , Zhou Hanying , Meng Bin , Wang Hui , Xue Xia , Li Na , Shi Juanzi 
Published: May 2022

Abstract
Background
Day 5 (D5) blastocyst is generally given priority to transfer than Day 6 (D6) blastocyst, however, which one should be prioritized to transfer when only low-grade D5 and high-grade D6 blastocysts are available?
Methods
A large retrospective cohort study was carried out to evaluate the live birth rate (LBR) following D5 blastocyst and excellent D6 blastocyst in single frozen-thawed blastocyst transfer (FBT) during Jan 2014 and Dec 2018. The biopsied blastocysts form consecutive PGT-A case series during Feb 2013 to Dec 2021 were performed as a supplementary analysis.
Results
The LBR was highest in high-grade D5 blastocyst (57.60%) and lowest in low-grade D6 blastocyst (29.72%, vs high-grade D5, aOR 0.38, 95%CI 0.30–0.48, p < 0.001). The LBR achieved in high-grade D6 blastocyst transfer was significantly higher than low-grade D5 blastocyst (50.43% vs 40.70%, aOR 1.54, 95%CI 1.05–2.26, p = 0.027), and is comparable with that in high-grade D5 blastocyst (50.43% vs 57.60%, aOR 0.89, 95%CI 0.61–1.32, p = 0.568). There were no significant differences in preterm birth rate, very preterm birth rate, mean live birth weight, birth weight < 1500g and > 4000g between four cohorts. As for aneuploidy analysis in PGT, there were 54.55% of euploid blastocysts (30/55) among high-grade D6 blastocysts, significantly higher than 41.39% of euploid blastocysts (565/1365) among low-grade D5 blastocyst (p < 0.001).
Conclusions
Our data suggested Day 6 blastocyst with high morphology grading should be preferred than Day 5 blastocyst with low morphology grading when selecting blastocyst transfer to short the time of conceiving.
Trial registration:
This study was approved by the hospital institutional ethics committee (No. 2021002).
Physical Layer Security of Wireless Networks using Reconfigurable Intelligent Surfaces and Energy Harvesting For Nakagami fading channels
Authors: Alanazi Faisal 
Published: May 2022

Abstract
In this article, we compute the Secrecy
Outage Probability (SOP) and the Strictly Positive
Secrecy Capacity (SPSC) of wireless networks using
Reconfigurable Intelligent Surfaces (RIS) when
the source S harvests power from the signal received
from node N. The broadcasted signal by S
is reflected by RIS so that reflections have a zero
phase at the destination D. The transmitted signal
by S is also received by an eavesdropper E. We
also compute the SOP and SPSC when RIS is used
for data communication and energy harvesting.
IKZF3 amplification frequently occurs in HER2 positive breast cancer and is a potential therapeutic target
Authors: Lin ChihYi , Yu Chung-Jen , Shen Chia-I , Liu Chun-Yu , Chao Ta-Chung , Huang Chi-Cheng , Tseng Ling-Ming , Lai Jiun-I 
Published: May 2022

Abstract
Breast cancer is one of the leading causes of cancer death in women, and although treatment outcome has substantially improved in the past decades, advanced or metastatic breast cancers still carry a poor prognosis. Gene amplification is one of the frequent genetic alterations in cancer, and oncogene amplification may be associated with cancer aggressiveness and oncogenicity. Targeting amplified genes such as HER2 has vastly improved disease outcome and survival, and anti-HER2 therapeutics have revolutionized the standard of care in HER2 breast cancer. Besides currently known druggable gene amplifications including ERBB2 and FGFR2, other frequently amplified genes are relatively less well known for function and clinical significance. By querying 4 large databases from TCGA and AACR-Genie, from a total of 11,890 patients with invasive ductal breast carcinoma, we discover IKZF3, CCND1, ERBB2 to be consistently amplified across different cohorts. We further identify IKZF3 as a frequently amplified gene in breast cancer with a prevalence of 12–15% amplification rate. Interestingly, IKZF3 amplification is frequently co-amplified with ERBB2/HER2, and is also associated with worse prognosis compared to IKZF3 non-amplified cancers. Analysis of HER2 breast cancer patients treated with trastuzumab revealed decrease in both ERBB2/HER2 and IKZF3 expression. Further investigation using the DepMap for gene dependency by genome wide CRISPR screening revealed dependence on IKZF3 in HER2 breast cancer cell lines. Our study utilized an integrative analysis of large scale patient genomics, transcriptomics and clinical data to reveal IKZF3 as a frequently amplified gene, and suggest a potential role of IKZF3 as a druggable target for HER2 breast cancer.
Dynamic Algorithm for Fitness Function Greatly Improves the Optimization Efficiency of Frequency Selective Surface for Better Design of Radar
Authors: Pei Yuan , Yu Anran , Yi Ruichen , Qin Jiajun , Liu Shaobo , Yu Xianxi , Zhu Chunqin , Zhu Guangrui , Hou Xiaoyuan 
Published: May 2022

Abstract
Multiple objectives optimization of frequency selective surface (FSS) structures is challenging in electromagnetic wave filter design. For example, one of the sub-objectives, the sidelobe level (SLL), is critical to directional anti-interference, which is complicated and becomes the bottleneck for radar design. Here, we established a dynamic algorithm for fitness function to automatically adjust the weights of multiple objectives in the optimization process of FSS structures. The dynamic algorithm could efficiently evaluate the difficulty of sub-objective optimization according to the statistical analysis of the latest individual distribution so that the optimization could be tightly focused on the sub-objective hard to optimize, such as SLL. Computational results from the dynamic algorithm showed that the efficiency of multi-objective optimization was greatly improved by 213%, as compared to the fixed-weighted algorithm of the fitness function. Specifically for SLL, the efficiency rate increased even better, up to 315%. More interestingly, the FSS structures were most improved while picking median value or golden section value as the reference value. Taken together, the current study indicated that the dynamic algorithm with fitness function might be a better choice for more efficient optimization of FSS structures and potentially for the better design of lower SLL radar.
Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1
Authors: Tavarna Tanvi , Wolfe Bryce , Wu Xiao-jun , Reyes Leticia 
Published: May 2022

Abstract
Impaired spiral artery remodeling (IRSA) underpins the great obstetrical syndromes. We previously demonstrated that intrauterine infection with the periodontal pathogen, Porphyromonas gingivalis, induces IRSA in rats. Since our previous studies only examined the end stage of arterial remodeling, the aim of this study was to identify the impact of P. gingivalis infection on the earlier stages of remodeling. Gestation day (GD) 11 specimens, a transition point between trophoblast-independent remodeling and the start of extravillous trophoblast invasion, were compared to late stage GD18 tissues. P. gingivalis was found in decidual stroma of GD11 specimens that already had reduced spiral artery remodeling defined as smaller arterial lumen size, increased retention of vascular smooth muscle, and decreased invasion by extravillous trophoblasts. At GD11, P. gingivalis-induced IRSA coincided with altered uterine natural killer (uNK) cell populations, decreased placental bed expression of interleukin-18 (IL-18) with increased production of temperature requirement A1 (Htra1), a marker of oxidative stress. By GD18, placental bed IL-18 and Htra1 levels, and uNK cell numbers were equivalent in control and infected groups. However, infected GD18 placental bed specimens had decreased TNF + T cells. These results suggest disturbances in placental bed decidual stroma and uNK cells are involved in P. gingivalis-mediated IRSA.
Rapid prediction of multi-directionality of polished surface topography based on angular spectrum
Authors: Wang Qinghui , Fang Xiaolin , Xie Hailong , Li J.R. , Liao Zhaoyang 
Published: May 2022

Abstract
The multi-directionality of polished surface topography (PST) is a key index to characterize the polished surface quality and surface integrity, and its prediction before actual machining is of great significance to the toolpath planning, verification, and optimization. However, most related works reported thus far focus mainly on the material removal modeling but few on the prediction of multi-directionality. Hence, this paper proposes a fast method to precisely predict the multi-directionality of the PST for the pad-polishing process of freeform surfaces. With this method, a pressure distribution model and a material removal profile (MRP) model are first established, in which the MRP is founded subject to the quadratic function distribution. Then, to avoid the time-consuming integral operation in the MRP model, an artificial neural network is developed to fit the quadratic function of MRP. With this model, a multi-directionality prediction algorithm is further proposed based on the angular spectrum of the PST. Simulation and experimental studies have shown that the proposed method can predict the multi-directionality of the PST with very high accuracy and efficiency for various freeform surface polishing, showing great application potential in promoting the efficiency of toolpath planning and optimization to obtain isotropic PST.
DFT study on the disproportionation of methylchlorosilane catalyzed by AlCl3/ZSM-5(4T)@MIL-53(Al) core-shell catalyst
Authors: xu wenyuan , Huang Hongkun , Shen Mengsha , Fan Junjie , Xu Yu , Liu Siqi , Wang Yan , Chen Xi , Liao Mengyin , Yang Shaoming 
Published: May 2022

Abstract
Dimethyldichlorosilane is one of the most widely used monomers in the organic silicon industry chain. In the preparation process, it can be obtained by exchanging functional groups through disproportionation reaction. In this research, the disproportionation mechanism catalyzed by ZSM-5(4T)@MIL-53(Al) and AlCl3/ZSM-5(4T)@MIL-53(Al) core-shell catalysts was studied by using the density functional theory on the level of M06-2X/Def2-TZVP. The results showed that the two catalysts possessed different catalytic effect assigning to different acidic actives. The surface activity of ZSM-5(4T)@MIL-53(Al) core-shell catalyst modified by AlCl3 became the Lewis acid center of Al-Cl bond, which had better disproportionation activity than that before modification. Energies, frequency vibrations and IRC calculations, bond orders, ELF and LOL analyses can verify the reaction mechanism proposed in this research.
Nonlinear dynamic epidemiological analysis of effects of vaccination and dynamic
transmission on COVID-19.
Authors: Kambali Prashant N. , Abbasi Amirhassan , Nataraj C. 
Published: May 2022

Abstract
This paper is concerned with nonlinear modeling and analysis of the COVID-19 pandemic. We are especially interested in two current topics: effect of vaccination and the universally observed oscillations in infections. We use a nonlinear Susceptible, Infected, & Immune model incorporating a dynamic transmission rate and vaccination policy. The US data provides a starting point for analyzing stability, bifurcations and dynamics in general. Further parametric analysis reveals a saddle-node bifurcation under imperfect vaccination leading to the occurrence of sustained epidemic equilibria. This work points to the tremendous value of systematic nonlinear dynamic analysis in pandemic modeling and demonstrates the dramatic influence of vaccination, and frequency, phase, and amplitude of transmission rate on persistent dynamic behavior of the disease.
Study on avoiding method of infusion-site adverse events in chemotherapy with epirubicin and fosaprepitant employing immortalized human umbilical vein endothelial(HUEhT-1)cells and rats
Authors: Yamasaki Miho , Oda Keisuke , Ichinose Takashi , Mizuguchi Marie , Tominaga Shoko , Omoda Kei , Mori Nobuhiro , Maeda Yorinobu , Nishida Toshihiro , Murakami Teruo 
Published: May 2022

Abstract
The combination of intravenous fosaprepitant dimeglumine (FAP, Proemend® I.V. Infusion), an antiemetic drug, and chemotherapy with anthracyclines such as epirubicin (EPI) can cause infusionsite adverse events. Avoiding method of infusion-site adverse events was studied in immortalized human umbilical vein endothelial (HUEhT-1) cells and rats. Cytotoxicity of FAP, EPI, diluted Proemend®, Tween 80 and a combination of FAP and EPI, and the effect of cell-surface washing after application of diluted Proemend® on cytotoxicity were studied in HUEhT-1 cells. In rats, the effect of infusion-site washing after FAP infusion was evaluated by measuring the intravascular accumulation of EPI in the combined use of FAP followed by EPI. FAP, EPI, and diluted Proemend® exhibited cytotoxicity concentration-dependently and marked synergistic cytotoxicity was observed between FAP and EPI. In HUEhT-1 cells, the washing of the cell surface after the application of FAP reduced the synergistic cytotoxicity significantly. In rats, the washing of the infusion site with saline after FAP infusion greatly decreased the intravascular accumulation of EPI infused thereafter. In conclusion, the washing of the infusion site by IV tube flushing after FAP infusion avoids the infusion-site adverse events due to the decrease in the vascular accumulation of EPI administered thereafter.
CAPZA2 and TRIB1 genomes contribute to the pathogenesis of ankylosing spondylitis
Authors: Yao Yuanlin , Zhan Xinli , Jiang Jie , Liang Tuo , Chen Tianyou , guo Hao , Li Hao , Ye Zhen , Chen Wuhua , Chen Liyi , Chen Jiarui , Huang Shengsheng , Sun Xuhua , Wu Shaofeng , Zhu Jichong , Liu Chong 
Published: May 2022

Abstract
Purpose: The pathogenesis of ankylosing spondylitis is not yet clear. Identification of new marker genes and cellular subtypes of immune cells in the blood of patients and exploration of new genetic loci in the pathogenesis of ankylosing spondylitis.Methods: We downloaded single-cell RNA-seq profiles (GSE157595) and microarray datasets (GSE25101 and GSE73754) from the Gene Expression Omnibus (GEO) database and performed principal component analysis, GO enrichment analysis, KEGG pathway analysis, t-distribution random-adjacent embedding analysis, and analysis using SVM and WGCNA to identify marker genes. The intersection of SVM and single cell sequencing marker genes: CAPZA2 and TRIB1, were taken for testing of diagnostic model building ROC curves and immunohistochemical validation analysis.Results: CAPZA2 and TRIB1 were identified as new diagnostic genes for AS. These two genes showed significant differential expression between AS and controls, and immunohistochemical results showed that the expression of CAPZA2 and TRIB1 was significantly higher in AS than in controls.Conclusion: CAPZA2 and TRIB1 may be key factors in the pathogenesis of ankylosing spondylitis.
Integrated analysis of the expression profiles of the lncRNA-miRNA-mRNA ceRNA network in granulosa and cumulus cells from yak Ovaries
Authors: Zhao Ling , Pan Yangyang , Wang Meng , wang Junqian , Wang Yaying , Han Xiaohong , Wang Jinglei , Zhang Tongxiang , Zhao Tian , He Honghong , Cui Yan , Yu Sijiu 
Published: May 2022

Abstract
Background: Growing oocytes acquire the ability to mature through two-way communication between gametes and surrounding somatic cumulus cells (CCs). Granulosa cells (GCs) support oocyte growth, regulate meiosis progression, and modulate global oocyte transcription activity. However, the proliferation and differentiation of the yak ovary in GCs and CCs remain unclear. To characterize the important roles of lncRNAs, miRNAs, and mRNAs, whole-transcriptome analysis was performed. Real-time quantitative fluorescence PCR was performed to verify the selected RNA sequences. Results: Important gene ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways related to differentiation and oocyte development were identified for the target genes of differentially expressed lncRNAs, miRNAs, and mRNAs. In total,6,223 mRNAs (2,197 upregulated, 4,026 downregulated), 643 lncRNAs (204 upregulated, 479 downregulated), and 559 miRNAs (311 upregulated, 248 downregulated) were significantly altered between the two groups; Target genes involved in cell adhesion, cell differentiation, regulation of developmental processes, cell proliferation, embryo development, signal transduction, apoptosis, and aromatic compound biosynthetic processes were significantly enriched. These RNAs were involved in ECM-receptor interaction, MAPK signaling, Hippo signaling, PI3K-Akt signaling, cell cycle, cell adhesion, leukocyte trans-endothelial migration, and actin cytoskeleton regulation.Conclusions: A comprehensive analysis of the co-expression network of ceRNAs will facilitate the understanding of the process of granulosa cell proliferation and differentiation and offer a theoretical basis for the development of oocytes.