bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compressive strength and anti-chloride ion penetration assessment of geopolymer mortar merging PVA fiber and nano-SiO2 using RBF–BP composite neural network
Authors: Zhang Xuemei , Zhang Peng , Wang Tingya , Zheng Ying , Qiu Linhong , Sun Siwen 
Published: March 2022

Abstract
In this study, we investigated the mechanical properties and chloride ion permeation resistance of geopolymer mortars based on fly ash modified with nano-SiO2 (NS) and polyvinyl alcohol (PVA) fiber and metakaolin (MK) at dose levels of 0–1.2% for PVA fiber and 0–2.5% for NS. The Levenberg–Marquardt (L–M) back propagation (BP) neural network, as well as the radial-based function (RBF) neural network, was used to predict the compressive strength and chloride ion permeation resistance of the geopolymer mortar with different admixtures of nanoparticles and PVA fiber, wherein the electric flux value was used as the index for chloride ion permeation performance. The RBF–BP composite neural network was constructed to study the compressive strength and chloride ion permeation resistance of nanoparticle-doped and PVA fiber ground geopolymer mortars. According to the experimental results of the RBF–BP composite neural network model, the mean square error (MSE) was observed to be 0.00071943, root mean square error (RMSE) was 0.026822, and mean absolute error (MAE) was 0.026822, thereby showing higher prediction accuracy, faster convergence, and better fitting effect compared with the single BP neural network and RBF neural network models. In this study, we combined the RBF–BP composite artificial neural network, providing a new method for the future assessment of the compressive strength and chloride ion penetration resistance of geopolymer mortar merging PVA fibers and NS in experiments and engineering studies.
Akzeptanz der CO2-Bepreisung in Deutschland: Die große Bedeutung einer Rückverteilung der Einnahmen
Authors: Frondel Manuel , Helmers Viola , Mattauch Linus , Pahle Michael , Sommer Stephan , Schmidt Christoph M. , Edenhofer Ottmar 
Published: March 2022

Zusammenfassung
Im Jahr 2021 wurde in Deutschland die sogenannte CO2-Bepreisung fossiler Kraft- und Brennstoffe eingeführt, um deren Verbrauch zum Zwecke des Klimaschutzes zu reduzieren. Dieser Preisaufschlag auf fossile Energieträger wird in den kommenden Jahren sukzessive erhöht. In diesem Beitrag untersuchen die Autoren die Akzeptanz der CO2-Bepreisung für die Zeit vor Einführung des CO2-Preises im Jahr 2019. Eine Erhebung unter mehr als 6.000 Haushalten zeigt, dass eine leichte absolute Mehrheit von 53,7 Prozent der Befragten grundsätzlich bereit ist, zu Klimaschutzzwecken höhere Kosten in Kauf zu nehmen. Die Zustimmung zu einer CO2-Bepreisung nimmt jedoch mit sinkendem Einkommen deutlich ab: Bei Befragten der untersten Einkommensgruppe liegt die Zustimmungsrate knapp unter 40 Prozent. Erwartungsgemäß verringert sich die Zustimmung auch mit der Höhe des CO2-Preises. So wurde ein CO2-Preis von 50 Euro von einer Mehrheit der Befragten von 50,6 Prozent abgelehnt. Um bei bis zum Jahr 2025 auf 55 Euro steigenden CO2-Preisen die mehrheitliche Akzeptanz der Bürger zu gewinnen, wird hier für einen breit angelegten Ausgleichsmechanismus durch die Reduzierung verzerrender und sozial ungerechter Steuern und Abgaben auf den Strompreis plädiert, die insbesondere Gering- und Durchschnittsverdienern zugutekommt. Andernfalls könnten die über die Zeit steigenden CO2-Preise eine hohe soziale Sprengkraft entfalten.
Histological, functional and transcriptomic alterations in the juvenile hippocampus in a mouse model of thyroid hormone resistance
Authors: Fang Yingxin , Dang Pingping , Liang Yue , Zhao Defa , Wang Ranran , Xi Yue , Zhang Dan , Wang Wei , Shan Zhongyan , Teng Weiping , Teng Xiaochun 
Published: March 2022

Background
Proper thyroid hormone signaling via the TRα1 nuclear receptor is required for normal neurodevelopmental processes. The specific downstream mechanisms mediated by TRα1 that impact brain development remain to be investigated.

Methods
In this study, the structure, function and transcriptome of hippocampal tissue in a mouse model expressing the first RTHα mutation discovered in a patient, THRA
E403X, were analyzed. RNAscope was used to visualize the spatial and temporal expression of Thra1 mRNA in the hippocampus of WT mice, which is corresponding to THRA1 mRNA in humans. The morphological structure was analyzed by Nissl staining, and the synaptic transmission was analyzed on the basis of long-term potentiation. The Morris water maze test and the zero maze test were used to evaluate the behavior. RNA-seq and quantitative real-time PCR were used to analyze the differentially expressed genes (DEGs) of the hippocampal tissues in the mouse model expressing the Thra
E403X mutation.

Results
The juvenile mutant Thra
E403X mice presented with delayed neuronal migration, disordered neuronal distribution, and decreased synaptic plasticity. A total of 754 DEGs, including 361 upregulated genes and 393 downregulated genes, were identified by RNA-seq. DEG-enriched Gene Ontology (GO) and KEGG pathways were associated with PI3K-Akt signaling, ECM−receptor interaction, neuroactive ligand−receptor interaction, and a range of immune-related pathways. 25 DEGs were validated by qPCR.

Conclusions
The ThraE403X mutation results in histological and functional abnormalities, as well as transcriptomic alterations in the juvenile mouse hippocampus. This study of the ThraE403X mutant offers new insights into the biological cause of RTHα-associated neurological diseases.
Impelementasi Kurikulum Merdeka Belajar di MIN 1 Wonosobo
Authors: Fakih Khusni Muhammad , Munadi Muh , Matin Abdul 
Published: March 2022

Pendidikan memiliki tujuan untuk mencetak generasi yang cerdas dan memiliki karakter yang berbudi. Penelitian ini bertujuan untuk mendeskripsikan implementasi merdeka belajar pada MIN 1 Wonosobo yang berdasar pada KMA Nomor 183 dan 184 tahun 2019. Menggunakan pendekatan deskriptif kualitatif. Objek yang diamati adalah MIN 1 Wonosobo. Data berupa dokumen. Strategi penelitian menggunakan analisis isi. Hasil penelitian menunjukkan KMA Nomor 183 tahun 2019 mengenai perancangan kurikulum di MIN 1 Wonosobo dirancang dengan berbagai pola, diantaranya adalah penggunaan struktur kurikulum yang berlaku pada semua mata pelajaran umum dan Mapel PAI- Bahasa Arab untuk semua kelas. Kurikulum pendukung seperti intrakurikuler, kurikuler dan ekstrakurikuler. Kemudian KMA Nomor 184 tahun 2019 mengenai pedoman implementasi berupa program prioritas, pengembangan diri dan pendidikan kecakapan hidup. Sedangkan untuk implementasi merdeka belajar, MIN 1 Wonosobo belum sepenuhnya menerapkan. Hal ini dibuktikan dari tabel yang menunjukkan banyaknya beban belajar dan mengajar.
Участие граждан в градорегулировании: теория и практика законодательного обеспечения
Authors: Сафарова Мария Динаровна 
Published: March 2022

Статья посвящена формам участия граждан в градорегулировании. В последнее время наблюдаются попытки перезапустить общественное участие. Импульсом к этому послужил старт реализации федерального проекта «Формирование комфортной городской среды» в 2018 году. Активно обсуждаются формы вовлечения горожан в процессы благоустройства города, адаптируются практики соучаствующего проектирования, жителей успешно привлекают к разработке документов благоустройства, и они могут видеть результаты своего труда в реализованных проектах. Параллельно продолжается сокращение общественного участия в обсуждении документов градорегулирования, устанавливающих правовые последствия для правообладателей недвижимости. Таким образом, фокус внимания горожан смещается с правовых вопросов, например с вопросов о границах земельных участков под многоквартирными домами, на выбор озеленения или игрового оборудования для детских площадок. В статье дан обзор форм участия граждан в решении вопросов местного значения. Эти формы представлены как спектр установленных законодательством возможностей общественного участия в решении вопросов градорегулировния. Определена роль публичных слушаний и общественных обсуждений как единственных форм обсуждения конкретных вопросов градорегулирования, обязательное проведение которой гарантировано законом. Все остальные формы участия граждан носят факультативный характер, и их применение во многом зависит от заинтересованности органов публичной власти. Также в статье подробно рассмотрены вопросы законодательного обеспечения публичных слушаний и общественных обсуждений в российских городах, проанализированы выявленные проблемы практики их применения. Все выводы подтверждены собранной автором статистической информацией. С позиции теории рациональной и справедливой организации процесса публичного обсуждения документов градорегулирования даны предложения по совершенствованию законодательства.
Вовлечение детей и подростков в городские проекты. Опыт проекта «Другой Данилов»
Authors: Дмитрий Валериевич Андреев 
Published: March 2022

Автор анализирует собственный опыт вовлечения детей и подростков малого российского города Данилова в социокультурные проекты по созданию или переосмыслению городских общественных пространств. Если в начале работы над проектом «Арх_и_тип» в мае 2017 года он видел в школьниках скорее пассивных исполнителей, то к 2019–2020 годам участники проектов все чаще становились авторами собственных творческих интервенций в городе. Длительная совместная работа на равных школьников и художников-кураторов над историческими граффити и арт-объектами, картой города и нескучным путеводителем по нему привела к тому, что из незнакомых до этого друг с другом школьников и взрослых сформировалось сообщество и одноименный зонтичный проект «Другой Данилов». Сообщество стало полноправным и активным участником городских культурных проектов: конкурсов по благоустройству, подготовке туристических маршрутов, приему гостей города. Поиск места для встреч привел к созданию собственного культурного центра, гражданского дома культуры в одном из расселенных городских особняков «Ленина 21», выкупленного автором у администрации города и переданного в управление школьникам, подросшим за время существования проекта «Другой Данилов». Автор раскрывает использованные приемы привлечения и мотивации школьников в ключевых самостоятельных проектах: «Арх_и_тип», «Наглядное пособие для нескучных прогулок по Данилову, составленное его юными жителями», «Открытый город. Художники — детям. Творческий практикум» и «Ленина 21». Он описывает удачи и неудачи реализованных им подходов в работе со школьниками, а также формулирует три группы рекомендаций для проектов, целевой аудиторией которых являются школьники: по взаимодействию с детьми и подростками, по выбору творческого наставника для подростков и по требованиям к пространству/площадке для встреч участников сообщества.
The dark proteome of rodent hepatitis E virus: Analysis of intrinsically disordered regions
Authors: Zoya Shafat , Anwar Ahmed , Mohammad K Parvez , Asimul Islam , Shama Parveen 
Published: March 2022

Hepatitis E virus (HEV) is the causative agent of Hepatitis E infections across the world. Intrinsically disordered protein regions (IDPRs) or Intrinsically Disordered Protein (IDPs) are regions or proteins that are characterized by a lack of definite structure. These regions or proteins play significant roles in a wide range of biological processes, such as cell cycle regulation, control of signaling pathways, etc. IDPRs or IDPs in proteins are associated with the virus’s pathogenicity and infectivity. The occurrence of intrinsic disorder in the proteome of rat HEV remains to be elucidated, which prompted us to explore its dark proteome. In this study, the unstructured/disordered regions of ORF proteins of rat HEV have been examined. We have analyzed the prevalence of intrinsic disorder by using a set of computational predictors. The intrinsic disorder propensity analysis showed that the ORF proteins consisted of a varying fraction of intrinsic disorder. The ORF3 protein was identified with a maximum propensity for intrinsic disorder while the protein ORF6 showed the least propensity for the intrinsic disorder. Further, the analysis revealed ORF6 as highly structured protein (ORDP); ORF1 and ORF4 as moderately disordered proteins (IDPRs); and ORF3 and ORF5 as highly disordered proteins, categorizing them as ordered protein (ORDP), a protein having Intrinsically Disordered Region (IDPR) and Intrinsically Disordered Proteins (IDP) respectively. Such disordered regions may play several important roles in the pathogenesis and replication of viruses. Collectively, this comprehensive study data from our investigation suggested ORF protein’s role in the regulation and pathogenesis of rat herpesvirus.
Localización empresarial y reto demográfico. El rol de la fiscalidad portuguesa
Authors: Pablos Mateos Fátima 
Published: March 2022

La localización de las empresas responde a diversos factores. La fiscalidad es uno de ellos. Ciertamente, la adopción de medidas fiscales competitivas puede ser un incentivo capaz de atraer nuevas empresas. Así lo ha entendido Portugal. El país vecino ha desarrollado, en el ámbito de la fiscalidad, medidas territorializadas de discriminación positiva con el fin de atraer nuevas empresas a los territorios del interior, áreas que presentan importantes tasas de despoblación, envejecimiento y pobreza. Con la llegada de nuevas empresas al interior del país se pretende dinamizar ese territorio, procurando su desarrollo económico, fijar población y reducir las asimetrías regionales existentes en la actualidad.
El reto demográfico es una cuestión de plena actualidad, por ello, el objetivo de este trabajo será analizar los beneficios fiscales regulados por Portugal con el fin de incentivar la localización de empresas en el interior del país en respuesta a esta problemática.
Desarrollo constitucional del judicial review en el constitucionalismo peruano
Authors: Aparicio Aldana Zhenia Djanira 
Published: March 2022

La inserción del judicial review en el sistema constitucional peruano obedece al aporte del constitucionalismo liberal. Esta institución fue asimilada en el Perú a lo largo del S. XX, para llegar a ser consolidada como un mecanismo clave, en el ejercicio de la función jurisdiccional, de órganos como el Tribunal Constitucional y, el Poder Judicial ambos comisionados del poder constituyente.
El judicial review es acogido en la Constitución Política del Perú de 1993, en su art 138, bajo la figura de ser una función jurisdiccional y, cuyo antecedente claro, se encuentra en la constitución anterior de 1979. Así, desde su regulación constitucional, se conocerá como el constituyente peruano, ha ingresado esta institución y, su aplicación como mecanismo para controlar las leyes infraconstitucionales frente a la Constitución.
Al ser un mecanismo de control constitucional, se incidirá en el papel del Tribunal Constitucional y del Poder Judicial en la interpretación que del mismo se ha realizado en sus decisiones jurisprudenciales, con la finalidad de dar contenido a la manera de aplicar dicho control de la constitucionalidad en el orden jurídico peruano.
Informe anual sobre la situación jurídico-pública de la Comunidad Autónoma de Extremadura en 2021
Authors: Álvarez García Vicente , Arias Aparicio Flor , Hernández Diez Enrique 
Published: March 2022

El Informe de la Comunidad Autónoma de Extremadura constituye una crónica de la situación jurídica y político-institucional de la región en el año 2021.
Las cuestiones principales que se analizan en este Informe son: en primer lugar, las principales circunstancias que rodean la actividad político-institucional de la región; en segundo lugar, las líneas centrales de su actividad normativa –legislativa y reglamentaria–; y, en tercer lugar, sus relaciones interadministrativas y conflictuales –esencialmente con la Administración General del Estado–. Se cierra el Informe con el examen de alguna cuestión de relevancia socio-económica para la región. En este año se ha puesto el acento en el papel de Extremadura como territorio estratégico para la transición ecológica.
Analysis of incidence of patients with polypous rhinosinusitis of different age groups in Primorsky Krai for period of 2015–2019
Authors:   Pacific State Medical University,  Primorsky Krai, Vladivostok, 690002, Russia, Pavlush D. G. , Gilifanov E. A. ,   Pacific State Medical University,  Primorsky Krai, Vladivostok, 690002, Russia, Dyuizen I. V. ,   National Scientific Center for Marine Biology, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, 690041, Russia, Danish A. A. ,   Pacific State Medical University,  Primorsky Krai, Vladivostok, 690002, Russia, Egorova T. S. ,   Pacific State Medical University,  Primorsky Krai, Vladivostok, 690002, Russia, Khomyakova E. N. ,   Pacific State Medical University,  Primorsky Krai, Vladivostok, 690002, Russia, Gorzei Yu. I. ,   Pacific State Medical University,  Primorsky Krai, Vladivostok, 690002, Russia
Published: March 2022

An analysis was made of the incidence of polypous rhinosinusitis (PRS) in patients hospitalized in the department of Otorhinolaryngology of Vladivostok Clinical Hospital No. 1 for the period 2015–2019. The data obtained indicate that PRS is 1.1–1.6% of hospitalized persons. The largest number of treated patients are males 63% (n = 104), and females account for 37% (n = 61); the average age for men was 57.4±1.52, and for women, 57.37±1.76, while there is a trend toward an increase in the number of patients of working age whose onset of the disease falls from 18–46 years. Seasonality indicators do not have significant fluctuations. Three histological variants of polyps were distinguished. We divided the data of the histological conclusion of removed polyps into 3 types (edematous n = 60, allergic n = 63, fibrous n = 42) according to the morphological classification. The most common type of PRS in men is the edematous type of polyps 28% (n = 46), in women, allergic 18% (n = 30). Relapse of the disease is the most common problem in the postoperative period. The solution to this problem lies in dynamic observation, control of symptoms, and drug therapy. A number of patients require an interdisciplinary approach with the combined efforts of doctors of related specialties: otorhinolaryngologist, pulmonologist, allergist-immunologist, therapist, general family practitioner.
A few remarks on federal crime of money laundering in the Unites States
Authors: Płońska Anna 
Published: March 2022

The phenomenon of money laundering is, generally speaking, the practice of using a business to conceal cash or other assets that are the products of other criminal activ­ity. The money laundering legislation was developed from perceived difficulties with enforcement of the currency transaction reporting requirements of the Bank Secrecy Act BSA. In 1986 the US Congress for the first time attempted to define and criminal­ized anactivity nowadays commonly known as money laundering. This paper presents some of the most essential aspects of federal crime of money laundering in the Unites States, indicating such types as: laundering of monetary instruments, engaging in mon­etary transactions in property derived from specified unlawful activity, and unlicensed money laundering business, respectively stated under 18 U.S.C. §§ 1956, 1957, and 1960.
Mitophagy eliminates the accumulation of SARM1 on the mitochondria, alleviating programmed axon death in acrylamide neuropathy
Authors: Wang Shuai , Yong Hui , Zhang Cuiqin , Kang Kang , Song Mingxue , Yang Yiyu , Huang Zhengcheng , Wang Shu’e , Ge Haotong , Zhao Xiulan , Song Fuyong 
Published: March 2022

Abstract
Sterile-α and toll/interleukin 1 receptor motif containing protein 1 (SARM1) is the defining molecule and central executioner of programmed axon death (also known as Wallerian degeneration). Although it has been confirmed to have a mitochondrial targeting sequence and can bind to and stabilize PTEN-induced putative kinase 1 (PINK1) for mitophagy induction, deletion of the mitochondrial localization sequence disrupts SARM1 mitochondrial localization in neurons but does not alter its ability to promote axon degeneration after axotomy. The biological significance for mitochondrial localization of SARM1 remains elusive. Here, we demonstrated that the SARM1-dependent axonal destruction pathway was involved in acrylamide (ACR) neuropathy in vivo and in vitro, a moderate Wallerian-like programmed axonal death process. The up-regulated SARM1 accumulated on mitochondria, which interfered with mitochondrial dynamics and activated PINK1-mediated mitophagy. Importantly, rapamycin (RAPA) intervention eliminated mitochondrial accumulated SARM1 and partly attenuated ACR neuropathy. Thus, mitochondrial localization of SARM1 contributes to its clearance through the SARM1-PINK1 mitophagy pathway and mitophagy, in turn, negative feedback inhibits axonal degeneration. Mitochondrial localization of SARM1 is complementary to the coordinated activity of the pro-survival factor, nicotinamide mononucleotide adenyltransferase 2 (NMNAT2), and SARM1, and is part of the self-limiting molecular mechanisms of programmed axon death.
Synthesis of gold nanowires using laser ablation for improved colon biosensor
Authors: Fakhri Makram A , Ali Hiyam , Salim Evan T. , Hashim Uda 
Published: March 2022

Abstract
Gold nanowires (Au NWs) were prepared using 9 nsec ND-YAG laser ablation in Ethanol employing 532 nm and 1.064 nm wavelengths. The colloidal solution was investigated depending on the X-ray diffraction (XRD) technique, the photoluminescence (PL) spectra, and Ultraviolet-Visible (UV-VIS) spectroscopy. The FESEM results reveal the formation of smaller Nano rode size at Second-harmonic generation (SHG) wavelength where found to be about (30 nm at wavelength 532 nm and 0.44 μm at 1064nm). Using Finite Element Analysis the simulation of photonic crystal fiber (PCF) as biosensors were done, depended on surface plasmon resonance (SPR) phenomenon using COMSOL Multiphysics program. The hollow core-photonic crystal fiber (HC-PCF) HC-800 was thus overfilled with (water). The confinement loss (CL) of the fundamental mode for the proposed PCF with and without the gold nanoparticles was calculated, we observe without gold NPs the CL at the water and Colon tissue about (1.08E+03, 5.46E+02) dB/m, while at use the deposited PCF with gold NPs the results ensured the decrease more than in the confinement loss at the water and Colon tissue about (1.01E+03, 3.16E+02) dB/m with a clear shift toward higher wavelengths.
DNA-Based Species Identification of Shark Fins Traded in Thai Markets.
Authors: Klangnurak Wanlada , Arunrugstichai Sirachai , Manopawitr Petch , Krajangdara Tassapon 
Published: March 2022

Abstract
Shark fins are among the most highly prized seafood products in the world with massive consumption in Asia over the past several decades. The demand for shark fins is a major driver of the enormous population declines of elasmobranchs that are generally vulnerable to overexploitation. This study aims to better understand the species composition of shark fin products in Thailand and their conservation statuses by using DNA-based species identification. Various types and sizes of shark fins were collected from 4 locations in Thailand. DNA barcoding method based on a fragment of the cytochrome c oxidase subunit I (COI) gene was applied to species identification. The optional pathway to report any amplified samples to the possible lowest taxonomy level are presented. Fins from at least 13 shark species were found among the samples we collected from Thailand’s markets. The spottail shark (Carcharhinus sorrah) and the night shark (Carcharhinus signatus) were the two dominant species presented in this study. The conservation status listed in the IUCN Red List and Thailand Red Data were reported for identifiable species. Size-species specification was also discussed. Species composition reported in shark fin products potentially helps indicate the appropriate conservation action and increases awareness from monitoring the trade in elasmobranch products.