bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning Curve of Robotic Rectal Surgery Using Risk-Adjusted Cumulative Summation: A Five-Year Institutional Experience
Authors: Oshio Hiroshi , Konta Tsuneo , Oshima Yukiko , Yunome Gen , Okazaki Shinji , Kawamura Ichiro , Ashitomi Yuya , Kawai Masaaki , Musha Hiroaki , Motoi Fuyuhiko 
Published: October 2022

Abstract
Purpose
We delineated the learning phases of robot-assisted laparoscopic surgery for rectal cancer and compared the surgical and clinical outcomes between robot-assisted laparoscopic surgery and conventional laparoscopic surgery.
Methods
In total, 210 patients underwent rectal cancer surgery at Sendai Medical Center from 2015 to 2020. Conventional laparoscopic surgery was performed in 110 patients, while robot-assisted laparoscopic surgery was performed in 100 patients. The learning curve was evaluated using the cumulative summation method, risk-adjusted cumulative summation method, and logistic regression analysis.
Results
The risk-adjusted cumulative summation learning curve was divided into three phases: phase 1 (cases 1–48), phase 2 (cases 49–80), and phase 3 (cases 81–100). The length of hospital stay (13.1 days vs. 18.0 days, respectively; p = 0.016) and the surgical duration (209.1 minutes vs. 249.5 minutes, respectively; p = 0.045) were significantly shorter in the robot-assisted laparoscopic surgery group (phase 3) than in the conventional laparoscopic surgery group. The volume of blood loss was significantly lower in the robot-assisted laparoscopic surgery group (phase 1) than in the conventional laparoscopic surgery group (17.7 ml vs. 79.7 ml, respectively; p = 0.036). The International Prostate Symptom Score was significantly lower (indicating less severe symptoms) in the robot-assisted laparoscopic surgery group (p = 0.0131).
Conclusions
Robot-assisted laparoscopic surgery for rectal cancer was safe and demonstrated better surgical and clinical outcomes, including a shorter hospital stay, less blood loss, and a shorter surgical duration, than conventional laparoscopic surgery. Tactile familiarity can be acquired from visual information beyond 80 cases.
RNA m6A methylation regulates the malignancy and apoptosis of colorectal cancer cells via modulation of P53 expression
Authors: Lin Yu , Deng Guoming , Zhao Zhifang , Xin Jinge , Wang Hesong , Zhou Jiawang , Zhang Haisheng , Xie Guoyou , Li Jiexin , Bai Yang 
Published: October 2022

Abstract
N6-Methyladenosine (m6A) modification, which is methylated by methyltransferase-like 3 (METTL3), is critical for the progression of several cancers. However, the roles of m6A in the apoptosis of cancer cells have not been well illustrated. Our present study reveals that deletion of METTL3 promotes the apoptosis and impairs the migration and invasion of colorectal cancer (CRC) cells. Both sequencing analysis and in vitro assays confirm that P53, an important transcription factor of apoptosis, is involved in the m6A-regulated apoptosis of CRC. Mechanically, the occurrence of m6A in P53 coding region (CDS), but not 3’ untranslated region (UTR), inhibited the expression of P53. Loss and gain functional studies confirm that YTHDF2 mediates mRNA degradation of P53 mRNA in an m6A-dependent manner. Moreover, METTL3 up-regulation acts as an adverse prognosis factor for recurrence‐free survival of colorectal cancers. Our study highlights the critical roles of m6A in the regulation of apoptosis, in cancer cells, through modulation of P53 expression.
A superior articular process morphology prone to screws placement failure: an anatomical study of 299 patients via multi-slice spiral computed tomography.
Authors: Liu Xiang-ge , Liang Pei-jie , Liu Han-hui , Chen Biao , Chen Guang-fu , Zhao Xiao-dong 
Published: October 2022

Abstract
Purposes: This study aimed to investigate whether the morphology of the superior articular processes of L5 vertebra affected the accuracy of pedicle screw placement by reviewing 299 patients who had undergone L5 pedicle screw fixation over the past 12 months and measuring relevant parameters. Methods: We retrospectively analyzed patients who underwent L5 vertebra fixation at our spine surgery department from October 20, 2020 to October 20, 2021. Patients with spondylolisthesis, spondylolysis, and scoliosis were excluded. Parameters associated with the superior articular process were analyzed, including Mammillary process-Spinal canal Distance (MCD), Inter-Facet Distance (IFD), Inter-Pedicle Distance (IPD), Zygapophysial Joints Angle (ZJA), Superior Articular Width (SAW), and Lateral Recess Transverse Diameter (LRTD). The L5 vertebral body was reconstructed by Mimics 21.0, and the simulated L5 screws were inserted at multiple entry points to measure the Maximum Safe Transverse Angle (STAmax). Results:299 patients who underwent L5 vertebra fixation with 556 pedicle screws were analyzed. An MCD < 6mm was associated with a significant increase in screw placement failure rate and decrease in ZJA. The MCD was positively correlated with IFD. No significant change in IPD was observed. Mimics software analysis showed that the STAmax decreased with a decrease of MCD. When WBV < 6mm, 93% of the trans-mammillary vertical line was located within 50% of the pedicle. Conclusions: The superior articular process tended to narrow the spinal canal and exhibit a steep and a “cloverleaf” morphology when the MCD was < 6mm. This morphology increased the risk of operator mis-judgement resulting in screw placement failure. Assessment of the relationship between the trans-mammillary vertical line and the pedicle represents a simple method to predict abnormal morphology of the superior articular process before surgery.
Evaluation and prediction of silicon bioavailability in diverse silicon fertilizers
Authors: Zhu Yunling , Yan Guochao , Fan Xiaoping , Zhang Xinyuan , Ye Mujun , Liang Yongchao 
Published: October 2022

Abstract
Silicon (Si) is a widely recognized beneficial element in plants. The application of Si fertilizers has become a rather common agronomic practice for sustainable agricultural production. However, due to the vast diversity of Si fertilizers, no official method is currently available for estimating the availability of Si in different Si fertilizers to direct their field application. In this study, we evaluated the bio-available Si concentration in eight Si fertilizers differing in Si form and pH by using different extraction methods including HCl, NaOH, Amberlite resin, 3-morpholinopropane-1-sulfonic acid (MOPS), ammonium acetate, and citric acid. To test the effectiveness of these methods, we investigated the relationships between bio-available Si and plant growth and Si accumulation by conducting a pot experiment with rice. The results indicate that the Si fertilizers applied increased shoot biomass and grain weight, but no single extraction method could be used to assess the bioavailability of Si in all the Si fertilizers tested. Accordingly, based on Si sources and pH, we classified the tested fertilizers into three categories, i.e. alkaline, acid and amorphous Si fertilizers, to find out their suitable extractant. The correlation analyses clearly show that 1) 0.025 M ammonium acetate could accurately predict Si availability and shoot biomass for alkaline Si fertilizers (Slag and Fulibang), 2) the amount of Si extracted by 0.2 M NaOH from amorphous Si fertilizers (Elkem A, Elkem B and Tangshan) correlated well with Si availability and shoot biomass and 3) the amount of Si extracted by 0.5 M NaOH and citric from acid fertilizers (Shanjia 1, Shanjia 2 and Shanyin) could be used to assess Si availability and shoot biomass response, respectively. Furthermore, resin extraction was the best predictor of grain yield response for alkaline Si fertilizers (Slag and Fulibang) and acid fertilizers (Shanjia 1, Shanjia 2 and Shanyin), whereas the amount of Si extracted by 0.5 M NaOH could satisfactorily estimate the response of grain yield for amorphous Si fertilizers.
Will Africa meet the challenge of biodiversity conservation in the digital age?
Authors: GANGLO Jean Cossi 
Published: October 2022

Abstract

Digital accessible knowledge (DAK) is of utmost importance for biodiversity conservation; indeed, its use is indispensable to provide evidence and strategies to support decision-making on natural resource management and sustainable use. The Global Biodiversity Information Facility (GBIF, www.gbif.org) is a mega data infrastructure with more than two billion occurrence records as of 28 May 2022. It is by far the largest initiative assembling and sharing DAK to support scientific research, conservation, and sustainable development. We decided to analyze plant data published at the GBIF site at the scale of Africa. This will highlight the contribution of the continent to the GBIF and thereby underline data gaps across taxonomic groups, the basis of records, and geographic space. To achieve our purpose, we downloaded data from the Plantae kingdom from Africa. They are available at https://doi.org/10.15468/dl.f79228. We achieved data treatment and analysis using R, several packages and related functions. Although Africa is home to rich biodiversity with many hotspots, the global data contribution of Africa to the GBIF is still incredibly low (1.37%). Furthermore, there are huge disparities between African countries, with South Africa contributing alone for 65% of the data of the continent. The plant data of Africa (2,713,790 occurrence records) accounted for 9.11% of the data of the continent; this underlines huge gaps between taxonomic groups. Furthermore, Magnoliopsida was the dominant plant class with the highest number of records (79.62%) and the highest number of species (71.85%), followed by Liliopsida, with 15.10% of the records and 18.16% of the species. Two sources of records were dominant: preserved specimens (75.49%) and human observation (18.60%). In geographic space, plant data gaps are also quite large across the continent at either spatial resolution (half degree or one degree spatial grid cells); data completeness is more achieved in West Africa, East Africa, Southern Africa, and Madagascar. The large multidimensional data gaps identified in this study should be a priority addressed in future data collections. Accessibility either by roads or waterways and protected areas are underpinning factors of data completeness across the continent. We deplored important data loss during the process of data cleaning; indeed, the total number of records with adequate coordinates accounted for 71.03% of the initial data, while the data fitness for use in completeness analysis (records with adequate coordinates and full dates) was only approximately 65% of the total data records initially downloaded.
Study of a physiotherapy evaluation that applies the motor retraction phenomenon to auditory stimuli
Authors: Yamanaka Takumi , Takeuchi Shinta , Aoki Akino , Nishida Yusuke 
Published: October 2022

Abstract
The accuracy and precision of synchronization and phase coherence values have been used as evaluation measures of retraction. However, it has been pointed out that accuracy and precision of synchronization may show a discrepancy between neural entrainment and performance accuracy. Therefore, this study determined whether the phenomenon of motor retraction to auditory stimuli can be evaluated by using phase synchronization with tapping. For this purpose, we examined phase coherence values, surrogate data methods, and effect sizes from a mathematical perspective. The auditory stimulus interval at which retraction is most likely to occur was also identified. Specifically, tapping tasks at six tempi (400, 500, 600, 750, 1,000, and 2,000 ms) were performed on 20 young adults. A comparison of the data for each auditory stimulus condition revealed significant differences at 400, 500, 600, 750, and 1,000 ms. Moreover, the effect size was greatest at 400 ms. The results suggest that, among the five conditions in which retraction occurred, the 400 ms auditory stimulus interval had the lowest probability of being an error in retraction determination and was therefore deemed suitable for evaluation.
Shariah Board and Takaful Performance: Mediating Role of corporate social responsibility
Authors: sallemi nourhen , Zouari Ghazi 
Published: October 2022

Abstract
This study aims to investigate the impact of Shariah board characteristics ( Sahriah board size, cross-membership, qualification, and reputation) on the performance of takaful insurance providers of distinguishable Muamalah contracts (wakalah and mixt), mediated by corporate social responsibility. Our sample covers 30 Takaful insurances divided into two subsamples: 18 insurance wakalah contracts offered in Southeast Asia (SEA) and 12 insurance mixte contracts offered in GCC over the period 2010–2020. We used the PLSPM method for data analysis. Corporate social responsibility (CSR) activities contribute to the success of takaful insurance. In fact, CSR has a partial mediating effect on the relationship between Shariah board size, qualification, and Takaful performance based on Southeast Asian (SEA) countries and GCC. Furthermore, CSR has a full mediating effect on the relationship between cross-membership and takaful performance in SEA countries and a partial mediating effect on the relationship between cross-membership and takaful performance in GCC countries. Moreover, CSR has a partial mediating effect on the relationship between reputation and Takaful performance in both SEA and GCC countries. This study highlights that CSR is a source of efficiency that enhances Takaful’s performance. Regulators should appreciate this procedure for the formulation of suitable and useful ways to efficiently supervise the operations of Takaful insurance.
JEL classification – G22, G3
Looking for a needle in a haystack: Recovering tiny metal fragments of broken instruments during pediatric laparoscopic surgery
Authors: Lin Kaiwu , Zhang Bing , Bai Jianxi 
Published: October 2022

Abstract
Objective
The purpose of this study was to investigate the management of the rare case that tiny metal fragments of broken instruments falling into the abdominal cavity during pediatric laparoscopic surgery.
Methods
A retrospective review of patients with tiny metal fragments of broken instruments during pediatric laparoscopic surgery in our hospital. In addition, we searched and analyzed the relevant literature from 1 January 2000 to 31 December 2021 from the PubMed, EMBASE, and Cochrane Library databases.
Results
2 cases with tiny metal fragments of broken scissors during laparoscopic surgery were successfully recovered in our hospital. Together with our 2 cases, a total of 13 cases were reported instrument broken during laparoscopic surgery. 3 cases visible and other 10 cases underwent intraoperative fluoroscopy; 4 cases were taken out by the magnetic device; 1 case converted to a laparotomy; none of them result in retained surgical instrument. Management of the rare case mainly includ careful search, necessary fluoroscopy and magnet. First, stop the operation immediately. Then the environment was carefully viewed with unnecessary turning as much as possible. Next intraoperative fluoroscopys was used. A magnet was put into the abdominal cavity. After the metal foreign bodies were removed, fluoroscopy again for ensuring that the foreign body is removed without residue.
Conclusions
Management of recovering tiny metal fragments of broken instruments during pediatric laparoscopic surgery mainly includes careful view, necessary fluoroscopy and magnet.
Identifying liver metastasis-related hub genes in breast cancer and characterizing SPARCL1 as a potential prognostic biomarker
Authors: Chen Mingkuan , Zheng Wenfang , Fang Lin 
Published: October 2022

Abstract
Purpose: The liver is currently the third most common metastatic site for advanced breast cancer (BC), and liver metastases predict poor prognoses. However, the characterized biomarkers and mechanisms underlying liver metastasis in BC remain unclear.
Methods: The GSE124648 dataset was used to identify differentially expressed genes (DEGs) between BC and liver metastases. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to annotate these DEGs and understand the biological functions they are involved in. A protein–protein interaction (PPI) network was constructed to identify hub genes. Clinicopathological correlation of hub gene expression in patients with BC was determined. Gene set enrichment analysis (GSEA) was performed to explore DEG-related signaling pathways. SPARCL1expression in BC tissues and cell lines was verified (RT-qPCR). SPARCL1 knockdown was performed using siRNAs; its biological function in BC cells was then investigated.
Results: We identified 332 liver metastasis-related DEGs from GSE124648 and 30 hub genes, including SPARCL1, from the PPI network. SPARCL1was related to patient prognosis, and its expression in BC was associated with age, TNM stage, estrogen receptor (ER) status, progesterone receptor (PR) status, histological type, molecular type, and living status of patients. GSEA results suggested that low SPARCL1 expression in BC was related to the cell cycle, DNA replication, oxidative phosphorylation, and homologous recombination. In vitro SPARCL1 inhibition promoted BC cell proliferation and migration.
Conclusion: We identified SPARCL1 as a tumor suppressor in BC, which shows potential as a target for BC and liver metastasis therapy and diagnosis.
Knowledge-Graph-Enabled Biomedical Entity Linking: A Survey
Authors: Shi Jiyun , Yuan Zhimeng , Guo Wenxuan , Ma Chen , Chen Jiehao , Zhang Meihui 
Published: October 2022

Abstract
Biomedical Entity Linking (BM-EL) task, which aims to match biomedical mentions in articles to entities in a certain knowledge base (e.g., the Unified Medical Language System), draws dramatic attention in recent years. BM-EL can help to disambiguate medical terms and link to rich semantic information in the biomedical knowledge base, which can act as an essential means for many downstream applications.Although entity linking tasks have been investigated in the general domain and achieved great success, many challenges remain in the biomedical field, for instance, highly complex terminology, less training data, and entity ambiguity.In this survey, we categorize BM-EL methods into rule-based, machine learning, and deep learning models according to the development of the model paradigm and provide a comprehensive review of each approach.In-depth study of current BM-EL efforts, we group the model architectures into four categories: joint entity recognition and linking, graph-based global entity disambiguation, cross-lingual architectures, and model-efficiency improvement.We further introduce six well-established datasets that are commonly used for BM-EL tasks. Furthermore, we present a comparison of the different methods and discuss their advantages and disadvantages.Finally, we discuss the limitations of existing methods for BM-EL and discuss promising future research directions.
First steps toward the knowledge of macrofaunal assemblages in rose gorgonian gardens from Central Chile: opening the door for conservation actions
Authors: Camps-Castellà Judith , Prado Patricia , Tena-Medialdea José , Brante Antonio , Hinojosa Iván 
Published: October 2022

AbstractGorgonian gardens of a new species of the generaLeptogorgiasp. are found in Central Chile. Little is known about these populations including depth distribution, colony abundance, structural attributes, and associated macrofaunal assemblages. Hierarchical sampling was conducted at 20 m depth (maximum colony abundances) in order to assess spatial variability in abundance and colony attributes at two spatial scales (among sites and rocky walls). The abundance and composition of the associated vagile and sessile macrofauna were also examined using univariant (Taxa richness, and Shannon index (H’e)) and multivariant approaches, and were compared with adjacent bare rocky habitats. Our results showed a high abundance of gorgonians (ca. 28.9 to 36.5 colonies m-2) compared to other gorgonian gardens in the world. For structural attributes, our results showed smaller colonies with thicker holdfasts in more exposed sites, suggesting the influence of hydrodynamic forces on the colony morphology. Taxa richness andH’eof vagile fauna showed 3-fold and 2-fold, respectively, higher values in gorgonian gardens compared to bare walls, but no differences were observed for sessile fauna. In addition, PCoA and PERMANOVA evidenced a distinctive assemblages’ composition between habitats for both vagile and sessile fauna. Correlation analyses and dbRDA showed, however, little association between structural attributes and associated faunal assemblages (R2=0.06, and ca. 3 to 9.4 % of the total variation explained, respectively). Our results constitute the first assessment of structural habitat complexity and accompanying fauna in these gorgonian gardens and establish the baseline for understanding possible future changes associated to human activities.
Predictive Assessment of the Consistency of Pituitary Adenomas Using Signal Intensity In Magnetic Resonance Imaging and Fractal Dimension of Histopathological Features
Authors: Gaia Felipe , Cavalcante-Filho José Renan Miranda , Reyes Lorenna Capovilla Martins Gonzales , Cortez Gustavo Maldonado , Belfort Marco Aurélio Franco Godoy , Cruz Oswaldo Laércio Mendonça , Zymberg Samuel Tau 
Published: October 2022

Abstract
PURPOSE
Recent studies have evaluated the presence of correlations between the magnetic resonance imaging (MRI) characteristics of Pituitary Adenomas (PAs) and their intraoperative tumor consistency. In this sense, predicting the consistency of preoperative PAs can help in selecting the most appropriate surgical approach for patients. However, the current literature lacks valid conclusions, and few articles that addressed the topic showed conflicting results. This study aimed to determine whether there is a correlation between the consistency of PAs and conventional MRI sequences, such as ADC, DWI, and FIESTA, in addition to a histopathological study of collagen and reticulin in these lesions, using Masson’s trichrome, reticulin, and fractal dimension (FD).
METHODS
Preoperative assessment was performed using MRI sequences, surgeons' perception of intraoperative consistency, and histopathological features using conventional methods (Masson's Trichomium and Reticulin) and FD.
RESULTS
The correlation between the MRI sequences and intraoperative consistency of the tumors did not show statistical relevance, and it was not possible to establish a specific signal intensity (SI) value for hard, intermediate, or soft tumors. No statistically significant correlation between the consistency of the tumor and quantification of collagen fibers, in both FD and conventional analyses.
CONCLUSION
The analysis of traditional MRI sequences plus ADC and FIESTA was not able to predict the consistency of the PAs. Moreover, it was found that collagen fibers identified through Masson’s trichrome, reticulin, and FD methods were not statistically associated with tumor consistency.