bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of cognitively engaging physical activity on executive functions in children
Authors: Bulten Rheanna , Bedard Chloe , Graham Jeffrey D. , Cairney John 
Published: August 2022

PurposePhysical activity (PA) has been shown to enhance executive functions (EFs) in children, and PA involving a cognitive component may confer additional benefit. The purpose of this study was to investigate whether cognitively engaging PA impacts EF, and whether affect and fitness act as either mediators or moderators of this relationship.MethodsA randomized controlled trial was utilized to assess changes in EFs between a 20-min Dual Task (intervention condition), a PA Task (control condition), and a Cognitive Task (control condition). Children were scheduled for two visits in the INfant and Child Health (INCH) Lab at the University of Toronto. Physical fitness was assessed using the 20 m shuttle run, standing long jump, and grip strength tests. EFs were assessed using the Stroop Task, Trail Making Task (TMT), and Forward Working Memory Task (FWMT).Results38 children (Mage = 11.95 years, SD = 0.49, 61% female) participated. Repeated measures ANOVA showed main interactions between time on inhibition scores (p &lt; 0.05, ηp2 = 0.489), and positive affect scores (p &lt; 0.01, ηp2 = 0.284). Interaction effects between condition and time were not significant (p = 0.787, ηp2 = 0.014, p = .333, ηp2 = 0.061, p = 0.799, ηp2 = 0.013 for inhibition, switching, and passive working memory, respectively). Results showed no significant mediation effect of affect (95% CI = –0.5915, 2.147), or moderating effect between fitness and EF changes.ConclusionPossible explanations for these findings include inadequate cognitive engagement, lack of EF transfer, and statistical power. Results suggest any of these interventions may be beneficial for improving inhibition and positive affect in children.
Exploring the social value of Public Health Institutes: An international scoping survey and expert interviews
Authors: Ashton Kathryn , Green Liz , Clemens Timo , Parry-Williams Lee , Dyakova Mariana , Bellis Mark A. 
Published: August 2022

IntroductionMaking the case for investing in preventative public health by illustrating not only the health impact but the social, economic and environmental value of Public Health Institutes is imperative. This is captured by the concept of Social Value, which when measured, demonstrates the combined intersectoral value of public health. There is currently insufficient research and evidence to show the social value of Public Health Institutes and their work across the life course, population groups and settings, in order to make the case for more investment.MethodsDuring July 2021, a quantitative online self-administered questionnaire was conducted across international networks. Semi-structured interviews were also carried out with nine representatives to gain a deeper understanding. A thematic analysis was undertaken on the data collected.ResultsIn total, 82.3% (n = 14) were aware of the terminology of social value and 58.8% (n = 10) were aware of the economic method of Social Return on Investment. However, only two Institutes reported capturing social and community impacts within their economic analysis and only 41.2% (n = 7) currently capture or measure the social value of their actions. Interviews and survey responses indicate a lack of resources, skills and buy-in from political powers. Finally, 76.5% (n = 12) wanted to do more to understand and measure wider outcomes and impact of their actions. It was noted this can be achieved through enhancing political will, developing a community of best practice and tools.ConclusionThis research can inform future work to understand how to measure the holistic social value of Public Health Institutes, in order to strengthen institutional capacity and impact, as well as to achieve a more equitable society, and a more sustainable health system and economy, making the case for investing in public health, as we recover from COVID-19.
Association between polyunsaturated fatty acid intake and infertility among American women aged 20–44 years
Authors: Wang Ruohan , Feng Ying , Chen Jiahe , Chen Yingjiao , Ma Fang 
Published: August 2022

BackgroundInfertility is a nationwide public health priority in the U.S. However, few studies have investigated the effects of dietary intake of polyunsaturated fatty acids (PUFAs) on female infertility. This study explored the association between PUFA intake and risk of infertility.MethodsA total of 1,785 women aged 20–44 years from three National Health and Nutrition Examination Survey cycles (2013–2018) were included in this cross-sectional study. The intake of PUFAs was obtained from a 24-h dietary interview on two separate days with a 3–10-day interval, and nutrient residue models were used. Fertility status was assessed by positive response to two relative questions via a questionnaire. Logistic regression models were used and some covariates were adjusted.ResultsAmong all the participants, 340 (19.05%) women suffered from infertility. The intake of docosahexaenoic acid (DHA) (OR = 0.998, 95% CI 0.998, 0.009) was slightly related to the risk of infertility. In contrast, women with higher α-linolenic acid (ALA) (OR = 1.416, 95% CI 1.138, 1.763) and linoleic acid (LA) intake (OR = 1.020, 95% CI 1.002, 1.038) presented with a relatively higher risk of primary infertility. Furthermore, in 20–34-year-old women, higher omega-6/omega-3 was significant associated with the risk of infertility (OR = 1.002, 95%CI 1.000, 1.005).ConclusionsOur results suggest that PUFA intake is only slightly associated with infertility. The higher the DHA intake, the lower the risk of infertility regardless of age. In women with primary infertility, ALA and LA has negative effect.
Drug sensitivity of clinical isolates of Mycobacterium tuberculosis and its association with bacterial genotype in the Somali region, Eastern Ethiopia
Authors: Worku Getnet , Gumi Balako , Girma Musse , Mohammedbirhan Binyam , Diriba Getu , Seid Getachew , Getu Melak , Amare Misikir , Sinshaw Waganeh , Ashagre Wondimu , Tschopp Rea , Carruth Lauren , Ameni Gobena 
Published: August 2022

BackgroundDrug resistance is becoming a major bottleneck for tuberculosis (TB) control programs in countries with high TB burdens. Although several studies were conducted on the drug sensitivity of Mycobacterium tuberculosis (M. tuberculosis) in central Ethiopia, there is a lack of data on the drug sensitivity of M. tuberculosis in the peripheral regions of the country including in the Somali region. Therefore, the objective of this study was to evaluate the drug sensitivity of M. tuberculosis and its association with bacterial genotype and evaluate the performance of Xpert MTB/RIF (Xpert) in detecting resistance to rifampicin (RIF).MethodsA total of 302 M. tuberculosis were tested using the BD BACTEC-Mycobacteria Growth Indicator Tube 960 (MGIT 960) system for their drug sensitivity to the first-line anti-TB drugs. Besides, the drug sensitivity of 10 multidrug-resistant (MDR) M. tuberculosis isolates was evaluated for the second-line anti-TB drugs. Additionally, 177 of the 302 isolates were tested for genotypic drug resistance using Xpert. Chi-square and Fisher's exact tests were used for the evaluation of the association between variables and drug sensitivity.ResultsThe overall prevalence of resistance to at least one drug was 11.6% (95% CI: 7.9–15.2%), while the prevalence of MDR was 3.3% (95% CI: 1.3–5.3%). Two of the 10 MDR isolates were resistant to capreomycin. The spoligotype Shared International Type (SIT) 149 was significantly associated with either monoresistance or MDR (p &lt; 0.05). Of the 177 isolates tested by Xpert, 6.2% (11/177) were RIF-resistant. Discordant between Xpert and MGIT 960 was observed in one isolate and linked with probe-binding delay (ΔCT max = 5.8). The sensitivity and specificity of the Xpert assay were 100 and 99.4%, respectively, while its positive and negative predictive values were 90.9 and 100%, respectively.ConclusionThe magnitude of MDR M. tuberculosis in the Somali region of Ethiopia was higher than the national prevalence of MDR-TB warranting the strengthening of the TB control program in the Somali region. Besides, drug resistance was associated with SIT 149 spoligotype (genotype). The Xpert assay was observed to have high sensitivity and specificity in detecting RIF-resistant M. tuberculosis, which is encouraging for its application widely.
The impact of COVID-19 on self-reported burnout and health and mental health services in Nampula, Mozambique
Authors: Feliciano Paulino , Mootz Jennifer J. , Suleman Antonio , Su Austin Y. , Khan Saida , Gouveia Lidia , Santos Palmira , Wainberg Milton L. , Sweetland Annika C. 
Published: August 2022

BackgroundThe purpose of this study was to examine the impact of the COVID-19 pandemic on self-reported burnout of health workers, quality of care, and perceptions of COVID-19-related stigma in Mozambique.MethodWe conducted a cross-sectional quantitative assessment of 170 frontline health workers in Nampula District, Mozambique, including 149 (87.6%) primary care providers and 21 (12.4%) mental health specialists.ResultsOf the 170 frontline workers, only 10.1% of frontline workers were experiencing more professional burnout, whereas 33.3% felt it had lessened. The perceived impact on quality of care also varied, without any significant differences by sex, education level, or mental health training background. Compared to the beginning of the COVID-19 pandemic in March 2020, 42.3 and 38.1% providers felt that their ability to provide mental health and general health care, respectively, had worsened, compared to 57.7 and 61.9% who believed that either there was no change, or that the work had become easier. Likewise, 26.8% of providers felt that their ability to meet patients' needs had gotten more difficult, whereas 43.4% reported no change and 29.8% reported that it was easier. Twenty-two percent of providers reported an overall increase in caseloads since before the pandemic whereas the majority (67.9%) reported a decrease. Providers believed that 57.1% of people in general were afraid of people with COVID-19, 27.5% were afraid of a person recovered from COVID-19, and 39.9% were afraid of a person with family members with COVID-19. The perceived stigma about healthcare professionals was also low; only 27.4% believed that people in general were afraid of healthcare providers who deliver care to people with COVID-19.ConclusionIn contrast with other global studies, many healthcare workers in our sample reported a reduction in burnout, which may be associated with the lower overall caseloads seen during this period. Similarly, the quality of care was minimally impacted. More research is needed to determine whether the experience in Mozambique is unique, or similarly observed in other low-resource settings.
Incoherent Thomson scattering: future implementation and measurement capabilities on the PANDORA experiment
Authors: Tsikata S. , Maunoury L. , Ducret J-E. 
Published: August 2022

The PANDORA (Plasmas for Astrophysics Nuclear Decays Observation and Radiation for Archaeometry) experiment aims to study the β-decay process inside a dense plasma mimicking stellar conditions. An electron cyclotron resonance plasma trap will be built at INFN-LNS in Catania, Italy, for the generation of the desired conditions in the laboratory. This type of non-equilibrium dense plasma (reaching densities of up to 1013 cm−3) is expected to generate electron energy distribution functions with electron energies ranging from tens of eV up to tens of keV. In this work, we describe aspects of a planned implementation of an incoherent Thomson scattering diagnostic for the study of electron properties in the plasma trap of PANDORA. The performance of this high-sensitivity diagnostic, known as THETIS, has been previously validated in measurements across a range of low-density magnetized plasma environments and it is expected to provide access to electron energy information in PANDORA in the range of temperatures from 1 to 103 eV. This article will establish the potential of such a diagnostic for future characterization of the electron properties in the PANDORA experiment.
Stable physical activity tracking during children's guided active play
Authors: Moghaddaszadeh Asal , Taqvi Urooj , Lee Caitlin , Lee Erran , Belcastro Angelo 
Published: August 2022

ObjectivePhysical activity (PA) decreases during childhood with PA tracking statistics showing moderate coefficients in early childhood moving to poor coefficients in late childhood. The age-related instability of PA tracking is attributed to variations in age-related PA behaviors when quantifying PA in different settings (in/out of school, sports camps, and habitual PA). This study has examined the stability of age-related PA for children (from 7 to 11 years) during self-paced guided active play (GAP) sessions separated by 12 months.MethodsChildren (n = 65) recruited from community camps in two consecutive years were assessed for growth and PA participation during GAP sessions (1 h.d−1 on 2 d.wk−1) using cooperative games. Accelerometer outputs were used to quantify PA and estimate energy expenditure (EE) and moderate-to-vigorous PA (MVPA). Tracking statistics were assessed by Spearman coefficients (r) and agreement scores for percentile rankings (Kappa (k)) after a 1-year interval.ResultsGrouped data for PA tracking (EE) over the 1-year interval showed strong coefficients (r = 0.88, p = 0.001) and moderate agreement scores (k = 0.54). Boys and girls showed similar results. During the 1-year interval, the MVPA tracking coefficient was r = 0.54 (p = 0.01) with a moderate k score of 0.47. Age-related PA (EE) tracking coefficients at 7 (r = 0.90), 8 (r = 0.88), 10 (r = 0.82), and 11 (r = 0.83) years showed strong coefficients except at 9 years (r = 0.51).ConclusionChildren's age-related PA tracking (EE and MVPA) is stable during self-paced GAP assessed over a 1-year interval. Since PA tracking is stable in self-paced GAP, GAP should be included in children's PA intervention strategies to improve health and fitness.
Metabolic and immune/inflammatory alterations induced by a triathlon under extreme conditions
Authors: Momesso Santos Cesar Miguel , Amaral Jônatas Bussador , Rossi Marcelo , Vieria Rodolfo Paula , Abad Cesar Cavinato Cal , Bachi André Luis Lacerda 
Published: August 2022

PurposeTo investigate the effects of triathlon racing under extreme conditions on metabolic and immune/inflammatory responses.MethodsThirteen amateur athletes participated in an extreme triathlon competition (swim – 3.8 km; cycling – 180 km; running – 4 2 km; with a 3,700 m accumulated altitude). Blood samples were collected on three different occasions: pre-competition (baseline), immediately post-competition (IM), and 12 h post-competition (12 h) to evaluate glycemic and lipid profiles, leukocytes count, and cytokines levels in plasma and in whole-blood cell culture supernatant stimulated or not with LPS.ResultsDecreased glucose and triglycerides levels, increased LDL, and a significant leukocytosis were observed at IM and 12 h compared to baseline. In addition, higher serum levels of IL-6, IL-8, and IL-10 were found at IM than in baseline and post-12 h. Whereas increased IL-12p40 levels were observed for 12 h compared to baseline. At baseline, in LPS-stimulated cell culture, IL-6, IL-8, and IL-12p70 were higher, while IL-12p40 levels were lower than non-stimulated cell culture. At IM, IL-12p40 levels were unchanged, while higher levels of other cytokines were found in LPS-stimulated cell culture compared to non-stimulated cell culture. The 12 h results showed higher levels of IL-6, IL-8, and IL-10 in LPS-stimulated cell culture than in non-stimulated cell culture. Additionally, a significant negative correlation between circulating glucose levels and IL-6 was found.ConclusionThe triathlon competition's performance under extreme conditions has remarkable impacts on the lipid profile and systemic immune/inflammatory responses. For the first time, significant alterations in the cytokine responses of whole blood cell culture to LPS-stimulation in baseline, IM, and 12h were demonstrated.
Population, economic and geographic predictors of nations' medal tallies at the Pyeongchang and Tokyo Olympics and Paralympics
Authors: Li Feifei , Hopkins Will G. , Lipinska Patrycja 
Published: August 2022

PurposeRanking of nations by medal tally is a popular feature of the Olympics, but such ranking is a poor measure of sporting prowess or engagement until the tallies are adjusted for major factors beyond the control of individual nations. Here we estimate and adjust for effects of total population, economy expressed as gross domestic product per capita, absolute latitude and Muslim population proportion on total medal counts in female, male, mixed and all events at the Pyeongchang winter and Tokyo summer Olympics and Paralympics.MethodsThe statistical model was multiple linear over-dispersed Poisson regression. Population and economy were log-transformed; their linear effects were expressed in percent per percent units and evaluated in magnitude as the factor effects of two between-nation standard deviations (SD). The linear effect of absolute latitude was expressed and evaluated as the factor effect of 30° (approximately 2 SD). The linear effect of Muslim proportion was expressed as the factor effect of 100% vs. 0% Muslim. Nations were ranked on the basis of actual vs. predicted all-events medal counts.ResultsAt the Pyeongchang Olympics, effects of population and economy were 0.7–0.8 %/% and 1.1–1.7 %/% (welldefined extremely large increases for 2 SD), factor effects of 30° of latitude were 11–17 (welldefined extremely large increases), and factor effects of 100% Muslim population were 0.08–0.69 (extremely large to moderate reductions, albeit indecisive). Effects at the Tokyo Olympics were similar in magnitude, including those of latitude, which were surprisingly still positive although diminished (large to very large increases). Effects at the Pyeongchang and Tokyo Paralympics were generally similar to those at the Olympics, but the effects of economy were diminished (large to very large increases). After adjustment of medal tallies for these effects, nations that reached the top-10 medalists in both winter games were Austria, Belarus, Kazakhstan, Slovakia and Ukraine, but only Azerbaijan reached the top-10 in both summer games.ConclusionAdjusting medal counts for demographic and geographic factors provides a comparison of nations' sporting prowess or engagement that is more in keeping with the Olympic ideal of fair play and more useful for nations' Olympic-funding decisions.
One-stage En bloc resection of thoracic spinal chondrosarcoma with huge paravertebral mass through the single posterior approach by dissociate longissimus thoracis
Authors: Xu Wei , Ye Chen , Zhang Dan , Wang Peng , Wei Haifeng , Yang Xinghai , Xiao Jianru 
Published: August 2022

Study designRetrospective case series.ObjectiveTo describe the technique details and therapeutic outcomes of 3-D printing model-guided en bloc resection of chondrosarcoma (CHS) with huge paravertebral mass via the combined posterior median and Wiltse approach.Summary of background dataTotal en bloc spondylectomy (TES) technique is conventionally based on the single posterior approach or combined anterior-posterior approach. However, the single posterior approach imposes a high technical demand on the surgeon due to the narrow field of vision, limited surgical space and the delicate spinal cord, while the combined anterior-posterior approach not only requires greater patient tolerance but is time consuming and runs the risk of more blood loss and injury to the visceral pleura and large blood vessels during surgery. In addition, it is difficult to completely remove the thoracic CHS with paravertebral mass through simple en bloc resection when it involves the aorta, vena cava, costa and lung.Material and methodsBetween August 2010 and January 2016, we performed a retrospective study to evaluate the clinical characteristics and outcomes of en bloc resection of thoracic spinal CHS with paravertebral mass through the combined posterior median and Wiltse approach. Postoperative recurrence-free survival (RFS) and overall survival (OS) were estimated by the Kaplan-Meier method. P values less than 0.05 were considered statistically significant.ResultsAltogether 15 patients received en bloc resection of thoracic spinal CHS with paravertebral mass through the combined posterior median and Wiltse approach. The mean age of these patients was 37.0 ± 12.8 years (median 36; range 15–64). This combination approach provided more extensive exposure and wider marginal resection of the tumor within a mean operation duration of 288 ± 96 min (median 280; range 140–480) and mean intraoperative blood loss of 1,966 ± 830 ml (median 2,000; range 300–3,000). Of the 15 patients, 5 experienced local recurrence of the disease; the mean time from surgery to recurrence was 22 ± 9.85 months (median 17, range 13–35). RFS in patients with recurrent CHS was significantly lower than that in patients with primary CHS on admission (p = 0.05).ConclusionsThe combined posterior median and Wiltse approach is a technically viable option for en bloc resection of thoracic spinal CHS with huge paravertebral mass, and can give a favorable local control of CHS.Level of evidenceLevel V.
Combined arthroscopic rotator cuff repair leads to better clinical outcomes than isolated removal of calcific deposits for shoulder calcific tendinitis: A 2- to 5-year follow-up study
Authors: Pang Long , Li Tao , Li Yinghao , Cao Yuanyinuo , Li Jian , Zhu Jing , Tang Xin 
Published: August 2022

PurposeThe optimal treatment procedure for shoulder calcific tendinitis (CT) remains controversial. This study aimed to assess the efficacy of arthroscopic treatment for CT, and to compare the clinical outcomes following combined rotator cuff repair and isolated removal of calcific deposits.MethodsThis retrospective cohort study included 46 patients (47 shoulders) with confirmed shoulder CT, and the diameter of the calcific deposit was over 1 cm. All patients suffered from CT for a mean period of 17.82 months and had a poor response to conservative treatment. With 12 males and 34 females included, the mean age was 53.94 years. After failed conservative treatment, 23 shoulders underwent combined rotator cuff repair (repair group), and 24 shoulders underwent isolated removal of calcific deposits (debridement group). The clinical outcomes were evaluated at baseline, 3, 6, and 12 months after the surgery and annually thereafter. The efficacy measures included the visual analog scale (VAS) pain score, American Shoulder and Elbow Surgeons (ASES) score, University of California at Los Angeles (UCLA) score and radiographic outcomes.ResultsRemarkable improvement in clinical outcomes at the final follow-up (2- to 5-year) compared with those at baseline were observed (p &lt; 0.0001 for all outcomes). Compared with isolated removal of calcific deposits, combined rotator cuff repair led to worse postoperative 3- and 6-month VAS (p = 0.004 and p = 0.026, respectively), and 3-month ASES scores (p = 0.012). However, better VAS (p = 0.035 and p = 0.007, respectively) and ASES (p = 0.034 and p = 0.020, respectively) scores at 24-month and final follow-up were found in the repair group. All these differences reached the minimal clinical important difference (MCID). MRI scans at the final follow-up showed significantly better outcomes in patients with rotator cuff repair (p = 0.021).ConclusionsArthroscopic removal of calcific deposits is safe and effective for treating CT. Compared with isolated debridement, combined rotator cuff repair led to worse short-term (&lt;12 months) but better medium- (12–48 months) to long-term (≥48 months) improvements in pain, function and integrity of tendons.