bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient plant regeneration via meristematic nodule culture in Paeonia ostii ‘Feng Dan’
Authors: Xu Li , Cheng Fangyun , Zhong Yuan 
Published: January 2022

AbstractTree peony (Paeonia sect. Moutan) is an economically important multipurpose woody plant in terms of its medical, ornamental and oil values, but its breeding and industrial development are severely limited due to inefficient traditional propagation methods and existing in vitro regeneration systems. Meristematic nodules (MNs) are an attractive alternative to solve this problem. This study first presented a protocol for in vitro regeneration of P. ostii ‘Feng Dan’ via MN culture with four consecutive steps, including embryogenic callus (EC) formation, MN induction and leaf cluster differentiation, shoot elongation, rooting and acclimatization. The highest EC induction rate (81.25%) was achieved when cotyledons were cultured on modified Murashige and Skoog (mMS) medium with 4.04 µM N-(2-chloro-4-pyridyl)-N-phenylurea (CPPU) + 5.37 µM α-naphthylacetic acid (NAA) for 30 days. The optimal MN induction rate (100%) and leaf cluster differentiation rate (45.83%) were obtained when ECs were cultured on modified woody plant medium (mWPM) supplemented with 2.02 µM CPPU + 2.27 µM thidiazuron (TDZ) for a subculture time of 10 days. The combination of 1.29 µM 6-benzyladenine (BA) + 0.58 µM gibberellin (GA3) yielded the best shoot elongation (13.40 shoots per nodule), rooting rate (43.33%) and consequently survival rate (45.83%). The study will be beneficial to the mass propagation, breeding and genetic improvement of tree peony.
Updated national emission inventory and comparison with the Emissions Database for Global Atmospheric Research (EDGAR): case of Lebanon
Authors: Shami Anwar Al , Aawar Elissar Al , Baayoun Abdelkader , Saliba Najat A. , Kushta Jonilda , Christoudias Theodoros , Lakkis Issam 
Published: January 2022

AbstractPhysically based computational modeling is an effective tool for estimating and predicting the spatial distribution of pollutant concentrations in complex environments. A detailed and up-to-date emission inventory is one of the most important components of atmospheric modeling and a prerequisite for achieving high model performance. Lebanon lacks an accurate inventory of anthropogenic emission fluxes. In the absence of a clear emission standard and standardized activity datasets in Lebanon, this work serves to fill this gap by presenting the first national effort to develop a national emission inventory by exhaustively quantifying detailed multisector, multi-species pollutant emissions in Lebanon for atmospheric pollutants that are internationally monitored and regulated as relevant to air quality. Following the classification of the Emissions Database for Global Atmospheric Research (EDGAR), we present the methodology followed for each subsector based on its characteristics and types of fuels consumed. The estimated emissions encompass gaseous species (CO, NOx, SO2), and particulate matter (PM2.5 and PM10). We compare totals per sector obtained from the newly developed national inventory with the international EDGAR inventory and previously published emission inventories for the country for base year 2010 presenting current discrepancies and analyzing their causes. The observed discrepancies highlight the fact that emission inventories, especially for data-scarce settings, are highly sensitive to the activity data and their underlying assumptions, and to the methodology used to estimate the emissions.
The Impact of COVID-19 on Routine Medical Care and Cancer Screening
Authors: Wenger Neil S. , Stanton Annette L. , Baxter-King Ryan , Sepucha Karen , Vavreck Lynn , Naeim Arash 
Published: January 2022

Abstract
Background
COVID-19 restrictions and fear dramatically changed the use of medical care. Understanding the magnitude of cancelled and postponed appointments and associated factors can help identify approaches to mitigate unmet need.

Objective
To determine the proportion of medical visits cancelled or postponed and for whom. We hypothesized that adults with serious medical conditions and those with higher anxiety, depressive symptoms, and avoidance-oriented coping would have more cancellations/postponements.

Design
Four nationally representative cross-sectional surveys conducted online in May, July, October, and December 2020.

Participants
59,747 US adults who completed 15-min online surveys. 69% cooperation rate.

Measures
Physical and mental health visits and cancer screening cancelled or postponed over prior 2 months. Plan to cancel or postpone visits over the next 2 months. Relationship with demographics, medical conditions, local COVID-19 death rate, anxiety, depressive symptoms, coping, intolerance of uncertainty, and perceived COVID-19 risk.

Key Results
Of the 58% (N = 34,868) with a medical appointment during the 2 months before the survey, 64% had an appointment cancelled or postponed in May, decreasing to 37% in December. Of the 41% of respondents with scheduled cancer screening, 20% cancelled/postponed, which was stable May to December. People with more medical conditions were more likely to cancel or postpone medical visits (OR 1.19 per condition, 95% CI 1.16, 1.22) and cancer screening (OR 1.20, 95% CI 1.15, 1.24). Race, ethnicity, and income had weak associations with cancelled/postponed visits, local death rate was unrelated, but anxiety and depressive symptoms were strongly related to cancellations, and this grew between May and December.

Conclusions
Cancelled medical care and cancer screening were more common among persons with medical conditions, anxiety and depression, even after accounting for COVID-19 deaths. Outreach and support to ensure that patients are not avoiding needed care due to anxiety, depression and inaccurate perceptions of risk will be important.
Notes on the H-measure of classifier performance
Authors: Hand D. J. , Anagnostopoulos C. 
Published: January 2022

AbstractThe H-measure is a classifier performance measure which takes into account the context of application without requiring a rigid value of relative misclassification costs to be set. Since its introduction in 2009 it has become widely adopted. This paper answers various queries which users have raised since its introduction, including questions about its interpretation, the choice of a weighting function, whether it is strictly proper, its coherence, and relates the measure to other work.
On the Influence of Alloy Composition on the Additive Manufacturability of Ni-Based Superalloys
Authors: Ghoussoub Joseph N. , Tang Yuanbo T. , Dick-Cleland William J. B. , Németh André A. N. , Gong Yilun , McCartney D. Graham , Cocks Alan C. F. , Reed Roger C. 
Published: January 2022

Abstract
The susceptibility of nickel-based superalloys to processing-induced crack formation during laser powder-bed additive manufacturing is studied. Twelve different alloys—some of existing (heritage) type but also other newly-designed ones—are considered. A strong inter-dependence of alloy composition and processability is demonstrated. Stereological procedures are developed to enable the two dominant defect types found—solidification cracks and solid-state ductility dip cracks—to be distinguished and quantified. Differential scanning calorimetry, creep stress relaxation tests at 1000 °C and measurements of tensile ductility at 800 °C are used to interpret the effects of alloy composition. A model for solid-state cracking is proposed, based on an incapacity to relax the thermal stress arising from constrained differential thermal contraction; its development is supported by experimental measurements using a constrained bar cooling test. A modified solidification cracking criterion is proposed based upon solidification range but including also a contribution from the stress relaxation effect. This work provides fundamental insights into the role of composition on the additive manufacturability of these materials.
Efficacy and safety of ferric derisomaltose (FDI) compared with iron sucrose (IS) in patients with iron deficiency anemia after bariatric surgery
Authors: Auerbach Michael , Achebe Maureen M. , Thomsen Lars L. , Derman Richard J. 
Published: January 2022

Abstract
Purpose
Iron deficiency is common following bariatric surgery, and treatment with intravenous iron is often required. This post hoc analysis of data from two randomized, open-label, multicenter trials evaluated the efficacy and safety of ferric derisomaltose (FDI; formerly iron isomaltoside 1000) versus iron sucrose (IS) over 4 weeks in adults with iron deficiency anemia (IDA) resulting from prior bariatric surgery.

Materials and methods
Data were pooled for participants who received FDI or IS in the PROVIDE or FERWON-IDA trials for the treatment of IDA post bariatric surgery. Efficacy outcomes included changes in hemoglobin (Hb) and iron parameters; safety outcomes included the incidence of adverse drug reactions (ADRs), serious or severe hypersensitivity reactions (HSRs), and hypophosphatemia.

Results
The analysis included 159 patients. Mean (standard deviation) cumulative iron doses were 1199 (± 347) mg for FDI and 937 (± 209) mg for IS. Compared with IS, FDI resulted in a faster and more pronounced Hb response, and a higher proportion of responders (Hb level increase ≥ 2 g/dL from baseline) at all time points. The incidence of ADRs was similar with FDI and IS (15.1% and 18.2%, respectively), with no serious ADRs or serious or severe HSRs reported. The incidence of hypophosphatemia was low and similar in both treatment groups, with no cases of severe hypophosphatemia observed.

Conclusions
In patients with IDA resulting from bariatric surgery, FDI produced a faster and more pronounced Hb response than IS. Both FDI and IS were well tolerated.

Graphical abstract
Analysis of the interactions between joint and component properties during clinching
Authors: Steinfelder Christian , Acksteiner Johann , Guilleaume Christina , Brosius Alexander 
Published: January 2022

AbstractClinching is a joining process that is becoming more and more important in industry due to the increasing use of multi-material designs. Despite the already widespread use of the process, there is still a need for research to understand the mechanisms and design of clinched joints. In contrast to the tool parameters, process and material disturbances have not yet been investigated to a relatively large extent. However, these also have a great influence on the properties and applicability of clinching. The effect of process disturbances on the clinched joint are investigated with numerical and experimental methods. The investigated process variations are the history of the sheets using the pre-hardening of the material, different sheet thicknesses, sheet arrangements and punch strokes. For the consideration of the material history, a specimen geometry for pre-stretching specimens in uniaxial tension is used, from which the pre-stretched secondary specimens are taken. A finite element model is set up for the numerical investigations. Suitable clinching tools are selected. With the simulation, selected process influences can be examined. The effort of the numerical investigations is considerably reduced with the help of a statistical experimental design according to Taguchi. To confirm the simulation results, experimental investigations of the clinch point geometry by using micrographs and the shear strength of the clinched joint are performed. The analysis of the influence of difference disturbance factors on the clinching process demonstrate the importance of the holistic view of the clinching process.
On assessing excess mortality in Germany during the COVID-19 pandemic
Authors: De Nicola Giacomo , Kauermann Göran , Höhle Michael 
Published: January 2022

AbstractCoronavirus disease 2019 (COVID-19) is associated with a very high number of casualties in the general population. Assessing the exact magnitude of this number is a non-trivial problem, as relying only on officially reported COVID-19 associated fatalities runs the risk of incurring in several kinds of biases. One of the ways to approach the issue is to compare overall mortality during the pandemic with expected mortality computed using the observed mortality figures of previous years. In this paper, we build on existing methodology and propose two ways to compute expected as well as excess mortality, namely at the weekly and at the yearly level. Particular focus is put on the role of age, which plays a central part in both COVID-19-associated and overall mortality. We illustrate our methods by making use of age-stratified mortality data from the years 2016 to 2020 in Germany to compute age group-specific excess mortality during the COVID-19 pandemic in 2020.
Perceptions of teachers towards COVID appropriate behaviors for school children in coastal South India
Authors: Kamath Sowmini Padmanabh , Mithra Prasanna , Joshi Jayateertha , Kamath Padmanabh , Unnikrishnan Bhaskaran , K. Jayashree , Rao Suchetha , S.R. Ravikiran , Pai Keshav , Kamath Nutan , Bhat Kamalakshi G. 
Published: January 2022

AbstractCOVID appropriate behavioral measures need to be followed once school reopens. School teachers being in the forefront could substantiate the feasibility of suggested safety measures. This study aimed to assess teachers’ perceptions towards COVID appropriate behaviors for children with school reopening and compare their mean scores between public versus private schools and across school boards. We conducted an observational school-based study of teachers over two months. Perceptions were scored using a five-point Likert symmetric agree to disagree scale. Results were expressed as proportions and analyzed using an independent sample t-test. Of the 547 teachers surveyed, most (> 90%) agreed to the suggested social distancing and hygiene measures. There was a significant difference in perception scores between private versus public schools and across boards regarding i) reducing the academic syllabus, ii) adopting a cloud-based system to integrate online-offline learning, and iii) conducting meetings online. In addition, measures such as i) teaching classes on alternate days with a limited number of children, ii) arranging benches/desks to maintain six feet distance between students, iii) dealing with psychological stress by counselors, and iv) arrangement with local hospitals for medical services were significant statistically across school boards. To conclude, most schoolteachers agreed with the need for social distancing and hygiene measures for children. There was a significant difference in perceptions between public versus private schools and across boards regarding academic syllabus, integration of online-offline student learning, number of children per class, the timing of classes, student seating arrangement, and medical/psychological guidance availability.
Parteiendifferenz in der lokalen Klimapolitik? Eine empirische Analyse der hessischen Klima-Kommunen
Authors: Schulze Kai , Schoenefeld Jonas J. 
Published: January 2022

ZusammenfassungMachen Parteien für die Klimapolitikgestaltung einen Unterschied? Diese Frage ist nicht nur angesichts des auf nationalen Beiträgen basierenden globalen Klimaregimes relevant, sondern auch, da die Klimapolitik häufig als stärker parteipolitisiert wahrgenommen wird als die Umweltpolitik im Allgemeinen. Der vorliegende Beitrag geht der Frage auf der kommunalen Ebene nach, die bislang in der Forschung zur umweltpolitischen Parteiendifferenzhypothese selten Beachtung findet. Am Beispiel des Bundeslandes Hessen prüfen wir erstens, ob Parteiendifferenzen eine Rolle für den Beitritt der hessischen Städte und Gemeinden zum Klimanetzwerk „Hessen aktiv: Die Klima-Kommunen“ spielen. Zweitens prüfen wir, ob die Erstellung der obligatorischen Aktionspläne unter den Mitgliedern des Netzwerks mit Parteiendifferenzen in Zusammenhang steht. Die Untersuchung beruht auf einer Ereignisdatenanalyse der hessischen Städte und Gemeinden über den Zeitraum von 2009 bis 2020. Die Ergebnisse deuten an, dass von Grünen (Ober‑)Bürgermeister*innen regierte Städte und Gemeinden eher den Klima-Kommunen beitreten. Allerdings finden wir keine Hinweise darauf, dass sich die Erstellung der Aktionspläne, und damit ein konkreteres klimapolitisches Engagement, auf die Parteizugehörigkeit der (Ober-)Bürgermeister*innen zurückführen lässt. Allerdings zeigt sich, dass die Wahrscheinlichkeit der Erstellung eines Aktionsplans mit der Stärke der Grünen in der Gemeindevertretung steigt. Diese heterogenen Ergebnisse lassen erkennen, dass die Parteiendifferenzhypothese auch zur Erklärung von Unterschieden in der kommunalen Klimapolitik beitragen könnte und dass weiterer Forschungsbedarf hierzu auf der lokalen Ebene besteht.
A practitioners approach to individual claims models for bodily injury claims in german non-life insurance
Authors: Wiedemann Marcel , John Daniel 
Published: January 2022

AbstractThe aim of our paper is to discuss the difficulties non-life actuaries are currently facing from a practical point of view. Based on this, we show that individual claims models are the key to address these difficulties and discuss how such models give actuaries a new and very powerful tool to explore further fields of application. Moreover, we address a very essential question: What data is needed for developing individual claims models? For bodily injury claims in German motor liability insurance, we shall derive specific attributes based on a detailed discussion of the legal background. All our ideas are based on practical experience for a large German motor insurance portfolio.
LMBOPT: a limited memory method for bound-constrained optimization
Authors: Kimiaei Morteza , Neumaier Arnold , Azmi Behzad 
Published: January 2022

AbstractRecently, Neumaier and Azmi gave a comprehensive convergence theory for a generic algorithm for bound constrained optimization problems with a continuously differentiable objective function. The algorithm combines an active set strategy with a gradient-free line search along a piecewise linear search path defined by directions chosen to reduce zigzagging. This paper describes , an efficient implementation of this scheme. It employs new limited memory techniques for computing the search directions, improves by adding various safeguards relevant when finite precision arithmetic is used, and adds many practical enhancements in other details. The paper compares and several other solvers on the unconstrained and bound constrained problems from the collection and makes recommendations on which solver to use and when. Depending on the problem class, the problem dimension, and the precise goal, the best solvers are , , and .
Automatic cabin virtualization based on preliminary aircraft design data
Authors: Walther Jan-Niclas , Kocacan Bahadir , Hesse Christian , Gindorf Alex , Nagel Björn 
Published: January 2022

AbstractPreliminary aircraft design and cabin design are essential and well-established steps within the product development cycle for modern passenger aircraft. In practice, the execution usually takes place sequentially, with the preliminary design defining a basic cabin layout and the detail implementation following in a subsequent step. To enable higher fidelity assessment of the cabin early in the design process—for example by means of virtual reality applications—this paper proposes an interface, which can derive detailed 3D geometry of the fuselage from preliminary design data provided in the Common Parametric Aircraft Configuration Schema (CPACS). This is a key step towards integration of cabin analysis and preliminary design in automated collaborative aircraft design chains, not only in terms of passenger comfort, but also manufacturability or crash safety. Like the TiGL Geometry Library for CPACS, the interface presented acts as a parameter engine, which translates data from CPACS into CAD geometry using the Open Cascade Technology library. However, the scope of TiGL is expanded significantly, albeit with an explicit focus on the fuselage, by including more details such as extruded frame and stringer profiles and floor structures. Furthermore, advanced knowledge management techniques are employed to detect and augment missing data. For virtual reality applications, triangulated representations of the CAD geometry can be provided in established exchange formats, creating an interface to common visualization platforms. Additionally, a new evolution of the cabin definition schema in CPACS is presented, to incorporate models of cabin components such as seats or sidewall panels enabling immersive virtual mock-ups.
Emergency Department Utilization, Hospital Admissions, and Office-Based Physician Visits Among Under-Resourced African American and Latino Older Adults
Authors: Cobb Sharon , Bazargan Mohsen , Assari Shervin , Barkley Lisa , Bazargan-Hejazi Shahrzad 
Published: January 2022

Abstract

Objectives
This study uses a theoretical model to explore (a) emergency department (ED) utilization, (b) hospital admissions, and (c) office-based physician visits among sample of under-resourced African American and Latino older adults.

Methods
Nine hundred five African American and Latino older adults from an under-resourced urban community of South Los Angeles participated in this study. Data was collected using face-to-face interviews. Poisson and logistic regression analysis were used to estimate the parameters specified in the Andersen behavioral model. Predictors included predisposing factors, defined as demographic and other personal characteristics that influence the likelihood of obtaining care, and enabling factors defined as personal, family, and community resources that support or encourage efforts to access health services.

Results
African American older adults have a greater frequency of hospital admissions, ED, and physician visits than their Latino counterparts. About 25%, 45%, and 59% of the variance of the hospital admissions, ED utilization, and physician visits could be explained by predisposing and enabling characteristics. Lower health-related quality of life was associated with a higher number of hospital admissions, ED, and physician visits. Financial strain and difficulty accessing medical care were associated with a higher number of hospital admissions. Being covered by Medicare and particularly Medi-Cal were positively associated with higher hospital admissions, ED, and physician visits.

Discussion
Compared to African American older adults, Latino older adults show higher utilization of (a) emergency department (ED) utilization, (b) hospital admissions, and (c) office-based physician visits. A wide range of predisposing and enabling factors such as insurance and financial difficulties correlate with some but not other types of health care use. Multi-disciplinary, culturally sensitive, clinic- and community-based interventions are needed to address enabling and predisposing factors that influence ED utilization and hospital admission among African American and Latino older adults in under-resourced communities.