bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual Health Literacy Among Adults With Intellectual Disabilities: A Scoping Review
Authors: McGrath Margaret , Chong Lok Yan Cheryl , Collings Susan , Pebdani Roxanna 
Published: February 2025

ABSTRACTBackgroundAlthough sexual health literacy is recognised as critical to sexual health and well‐being, little is known about how people with intellectual disabilities acquire or use sexual health literacy skills. This scoping review examined research to explore what is known about sexual health literacy among adults with intellectual disability.MethodWe used Arksey and O′Malley's scoping framework to guide our review. We searched five electronic databases and reference lists of full‐text articles. Inclusion criteria included (i) original research in peer reviewed journals; (ii) published in English; (iii) addressed perspectives or experiences of people with intellectual disabilities regarding sexual health literacy or related topics. Findings were reported according to the Preferred Reporting Items for Systematic Reviews and Meta‐analyses extension for scoping reviews (PRISMA‐Scr). All text labelled ‘results’, ‘findings’ or ‘discussion’ was subjected to interpretive content analysis.ResultsThe search strategy identified 5447 records, 102 met all eligibility criteria and were included for review. A conceptual framework to understand factors shaping sexual health literacy was developed. In this framework, sexual health literacy is underpinned by two fundamental pillars: sexual knowledge and sexual autonomy. The availability of sexual knowledge and sexual autonomy is threatened by several factors in the social environment: presumed sexual vulnerability and sexual incompetence, and expectations of heteronormativity and asexuality. Combined these factors reduce opportunities for acquisition of sexual knowledge and enactment of sexual autonomy and ultimately appear to limit sexual literacy among people with intellectual disabilities.ConclusionSexual health literacy is critical for people with intellectual disabilities to enjoy full sexual citizenship. Despite this limited attention has been paid to supporting people with intellectual disabilities to acquire and use sexual health literacy skills. Comprehensive education programs are needed to address this gap and ensure the rights of people with intellectual disabilities to engage in safe, pleasurable sexual experiences and enjoy good sexual health are upheld.
Attitudes Towards Sexuality and Sexual Orientation in People With Intellectual Disabilities: A Systematic Review
Authors: Armas Junco Laura , Posada Corrales Juan Antonio , Alonso Martínez Laura 
Published: February 2025

ABSTRACTOver time, sexuality has become a crucial aspect in people's lives, regardless of physical, intellectual or social conditions, ranging from sex and sexually transmitted diseases to gender identity and sexual orientation. The aim of this study was to carry out a review of the scientific literature on sexual orientation in people with intellectual disabilities from the Education and Health Sciences and to analyse how sex education is addressed in this group. To this end, a systematic review of research on sexual orientation in people with intellectual disabilities was carried out. The results obtained reveal that there is hardly any scientific corpus on this subject, so emphasis should be placed on the attitudes towards LGTBIQA+ people with intellectual disabilities, as well as on the training and understanding of the different sexual orientations they may have. It is essential to face the obstacles, stigmas and prejudices established in society to normalise the sexual needs of these people, improving, consequently, their quality of life.
Association of opportunistic bacterial pathogens with female infertility: A case–control study
Authors: Hasan Zahid , Begum Nurjahan , Ahmed Sangita , Yasmin Mahmuda 
Published: February 2025

AbstractAimInfertility affects a significant proportion of women worldwide, and the colonization of certain vaginal pathogens has been suggested as a possible contributing factor. To explore the relationship between bacterial pathogens and female infertility, a case–control study was conducted involving 55 infertile women as cases and 5 fertile women as controls.MethodConventional culture‐based techniques and biochemical assays followed by 16S rDNA sequence analysis were employed for the identification of vaginal isolates from the two groups. The strength of association between the isolated bacterium and infecundity was derived by odds ratio calculation.ResultsThe investigation revealed the presence of bacteria including Enterococcus faecalis, Escherichia coli, Bacillus spp., Acinetobacter baumannii, Pseudomonas spp., Micrococcus luteus, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus capitis, Staphylococcus epidermidis, and Staphylococcus saprophyticus in the vaginal swabs of infertile women. Of these, the odds ratios for Staphylococcus aureus, Klebsiella pneumoniae, E. faecalis, and E. coli were 5.43 (95% CI = 0.28, 103.49), 4.59 (95% CI = 0.24, 87.93), 2.25 (95% CI = 0.11, 44.16), and 1.70 (95% CI = 0.09, 34.01), respectively, displaying an association with infertility. Moreover, vaginal colonization of these four bacterial species was also dominant in cases that were diagnosed with pelvic inflammatory disease and idiopathic infertility by laparoscopic examination.ConclusionOverall, the findings of this study indicate a probable association between specific pathogenic microorganisms and women's barrenness, emphasizing the significant role of these disease‐causing agents in hindering conception. This highlights the significance of a complete understanding of the vaginal microbiome and emphasizes further research in this area.
The Role of Social Signaling and Ethnic Norms in Charitable Giving: A Field Experiment in Vietnam
Authors: Nguyen Quang , Kim Huong Trang , Trinh Minh , Chang Shing‐Wan 
Published: February 2025

ABSTRACTIn this field experiment involving ethnic and income groups in Vietnam, we explore the role of social signaling—a construct encompassing both status‐seeking and public recognition—in charitable giving. We find that individuals from the Hoa (Chinese) ethnicity and those in higher income brackets are more prone to engage in social signaling by donating more. Conversely, the Khmer, influenced by their ethnic norms, are less likely to use donations as a form of social signaling. Our findings align with a multifaceted theoretical model that integrates social signaling and ethnic norms to explain the complexities of charitable giving behavior. This study not only enriches our understanding of why people donate but also underscores the nuanced interplay of social signaling and cultural norms.
The Interdependence of Extraversion: Personality Differences in Utilizing Social Capital and Interdependent Happiness
Authors: Askitis Dionyssios 
Published: February 2025

AbstractThis paper adds critical detail on the role of personality, specifically the impact of extraversion, to recent findings on the relationship between social support resources and well‐being. Based on previous studies showing personality differences in utilizing social capital, as well as in positive outcomes, such as well‐being, we assume that extraversion interacts with both. Referencing our previous research and cultural psychological findings on the “interdependence” of extraversion in the Japanese context, we also expect that the interaction is stronger for emic interdependent happiness than for etic life satisfaction. Using a Japanese well‐being survey (n = 2,500) and interaction analysis, the study confirms a significant moderating impact of extraversion on the association of social capital and well‐being. The findings suggest that introverts benefit more from additional support resources, while extraverts are maintaining a higher level of well‐being compared at every level of support. However, introverts with high levels of social support surpass extraverts with low levels of support in terms of well‐being. As predicted, the interaction is stronger for interdependent happiness, emphasizing potential cultural effects. Possible underlying mechanisms and implications are discussed.
MRI‐based surrogates of brain clearance in narcolepsy type 1
Authors: van Heese Eva M. , Gool Jari K. , Lammers Gert Jan , van der Werf Ysbrand D. , van Osch Matthias J. P. , Fronczek Rolf , Hirschler Lydiane 
Published: February 2025

SummaryBrain clearance involves the drainage of waste molecules from the brain, a process that is suggested to be amplified during sleep. Recently proposed MRI‐based methods attempt to approximate human brain clearance with surrogate measures. The current study aimed to explore whether two brain clearance surrogates are altered in narcolepsy. We processed diffusion‐weighted and functional resting‐state images to extract two surrogates: Diffusion Tensor Imaging Along the Perivascular Space (DTI‐ALPS index), and dBOLD‐CSF coupling. Both measures were analysed in 12 drug‐free, awake people with narcolepsy type 1 and 11 age‐ and sex‐matched controls, as well as in relation to clinical features. We also assessed the correlation between the DTI‐ALPS index and dBOLD‐CSF coupling. The DTI‐ALPS index and dBOLD‐CSF coupling amplitude did not show significant differences between narcolepsy and controls, nor significant relations with the severity of excessive daytime sleepiness. We found a significant correlation between dBOLD‐CSF coupling and sleep efficiency, as well as a significant correlation between the DTI‐ALPS index and dBOLD‐CSF coupling. The hypothesis of altered brain clearance in narcolepsy type 1 is not supported by evidence from the current study. The two surrogates correlated with each other, suggesting that both offer different perspectives from the same underlying physiology. Yet, the suitability of the surrogates as brain clearance markers remains debatable. Whereas DTI is not exclusively sensitive to perivascular fluid, dBOLD‐CSF coupling is reflecting large‐scale CSF motion. Future work should explore other surrogate markers, preferably during sleep, to better understand the possible role of altered brain clearance in narcolepsy type 1 symptomatology.
Pre‐clinical enteropathy in healthy soft‐coated wheaten terriers
Authors: Tolbert M. Katherine , Darrow Jewels , Grubb Louise , Fitzgerald Stuart , Bergee Rebecca , Price Josh , Mariano Marcos , Hong Michael , Sung Chi‐Hsuan , Hill Tracy , Steiner Joerg M. , Suchodolski Jan S. 
Published: February 2025

AbstractBackgroundSoft‐coated wheaten terriers (SCWTs) have a predisposition to the development of protein‐losing enteropathy (PLE). Early recognition of disease may improve morbidity and mortality in these and other at‐risk dogs. Preclinical inflammatory bowel disease (IBD), characterized by increased intestinal permeability, immune dysregulation and inflammation, and changes to the gut microbial composition, or biochemical evidence of disease many years before development of clinical signs, has been proposed for people at risk for IBD.Hypothesis/ObjectivesDetermine if changes in fecal metabolites and intestinal permeability could be identified in SCWTs before development of clinical signs. We hypothesized that, in contrast to healthy non‐SCWT dogs, healthy SCWT would have changes similar to those of dogs with PLE.AnimalsTwelve healthy SCWTs, 10 healthy non‐SCWTs, and 8 PLE dogs.MethodsProspective study. Fecal calprotectin, targeted metabolites and unconjugated bile acids, intestinal permeability testing, and video capsule endoscopy were evaluated. Single‐factor analysis of variance (ANOVA) was performed to evaluate fecal metabolites and bile acids for group differences. A repeated‐measures mixed model ANOVA was performed for blood lactulose:galactose area under the curve (AUC).ResultsSignificant differences among groups were found for several fecal fatty acids and sterols. Healthy non‐SCWT dogs, but not healthy SCWTs, were found to have significantly lower AUCs than PLE dogs (P = .04).ConclusionsHealthy SCWT dogs had changes in several biomarkers used to identify preclinical IBD in humans.
Association of Extreme Brachycephaly With Persistent Fontanelles in Adult Chihuahuas
Authors: Rautala Elina , Jokinen Tarja S. , Leikola Junnu , Ruohoniemi Mirja , Rusbridge Clare , Junnila Jouni J. T. , Kiviranta Anna‐Mariam 
Published: February 2025

ABSTRACTBackgroundAlthough persistent fontanelles (PFs) are common in adult Chihuahuas, their association with cranial morphology remains unknown.ObjectivesTo identify whether cranial morphology is associated with PFs in Chihuahuas and if bodyweight is associated with cranial morphology in this breed.AnimalsFifty client‐owned Chihuahuas.MethodsIn this retrospective cross‐sectional study using computed tomography images, we measured two different cranial base lengths (1 and 2), cranial length, height, and width, and two craniofacial angles. We calculated the ratios of cranial height to cranial base lengths 1 and 2, cranial height to length, cranial height to width, and cranial width to length (cranial index [CrI]). We evaluated if total PF area and number of cranial sutures affected by PFs were associated with craniometric measurements and their ratios and craniofacial angles. Additionally, we evaluated if the craniometric ratios were associated with bodyweight.ResultsTotal PF area was larger and number of cranial sutures affected by PFs higher in dogs with higher cranial height to cranial base length ratios 1 (estimate, [95% confidence interval], p: 2.295, [1.204–4.377], p = 0.01 and 1.720, [1.212–2.442], p = 0.002, respectively) and 2 (1.203, [1.069–1.354], p = 0.003 and 1.087, [1.011–1.169], p = 0.02, respectively) and CrI (1.225, [1.079–1.391], p = 0.002, and 1.134, [1.057–1.215], p < 0.001, respectively). Higher CrI was associated with lower bodyweight (−2.600, [−4.102 to −1.098], p = 0.001).Conclusion and Clinical ImportanceOur results suggest that in Chihuahuas, lower bodyweight is associated with more extreme brachycephaly and extreme brachycephaly is associated with PFs.
Insights Into Hepatic Sarcoidosis: Analysis of Histological Patterns, Hepatic Complications and Therapeutic Approaches
Authors: Horst Ludwig J. , Zimmermann Katharina , Lutz Johanna , Weidemann Sören , Lüth Stefan , Lohse Ansgar W. , Schulze zur Wiesch Julian , Schramm Christoph , Wehmeyer Malte H. , Müller Martina , Sebode Marcial 
Published: February 2025

ABSTRACTBackground and AimsSarcoidosis is a granulomatous multi‐systemic disorder of uncertain aetiology frequently involving the liver. This study aimed to delineate the histological characteristics, treatment effectiveness and factors predictive of liver‐related complications in individuals with hepatic sarcoidosis.MethodsThis retrospective cohort study included patients diagnosed with hepatic sarcoidosis by liver biopsy, which was conducted at two tertiary care centres from January 2009 to December 2023. We analysed demographic, clinical and laboratory parameters, treatment response and outcome.ResultsWe enrolled 70 hepatic sarcoidosis patients with a median follow‐up of 45 months (IQR 11–97 months), including 37 males with a median age of 48 years (IQR 37–59 years). Elevated GGT (94%) and ALP (81%) were the most common liver‐specific biochemical alterations observed. Using mini‐laparoscopy for liver biopsy made it possible to macroscopically identify granulomatous disease in 71% of patients. While at baseline, 16% of the cohort showed evidence of potential portal hypertension, at the last follow‐up, 23% of patients developed complications related to portal hypertension. In addition to granulomatous changes, bile duct irregularities were found in 57% of liver biopsies, indicating cholangiopathy being part of the hepatic manifestation of sarcoidosis. Treatment with Ursodeoxycholic acid and prednisolone resulted in a significantly more pronounced decrease in ALT and ALP compared to untreated patients.ConclusionsPatients with hepatic sarcoidosis require careful assessment of disease manifestation with a particular focus on portal hypertension. Treatment with UDCA and prednisolone leads to a reduction of biochemical parameters in a significant proportion of these patients.
Macroalgae and Light Availability Modulate the Distribution of the Temperate Coral Astrangia poculata
Authors: Lindsay Taylor , Dunster Willow , Prada Carlos 
Published: February 2025

ABSTRACTThe temperate coral Astrangia poculata is rapidly becoming a convenient system for studying symbiosis, microbiome, and thermal resilience. However, the ecology of this species is poorly understood. A. poculata is a temperate coral that employs facultative symbiosis to survive in cold, nutrient‐rich New England waters. The two ecotypes—symbiotic mixotrophic and aposymbiotic heterotrophic colonies—exist in the same environment, but their abundance changes across depth gradients. We conducted quadrat sampling along a depth gradient to quantify the density of A. poculata at Fort Wetherill State Park, RI, and determine the correlates of ecotype distribution. Further, we quantified light availability and macroalgal cover as possible ecological drivers of abundance. Symbiotic and aposymbiotic A. poculata exhibited a bell curve distribution along the depth gradient. In shallow environments, where both light and macroalgae are abundant, macroalgal cover was inversely related to coral density, implying a negative effect on coral abundance. In deeper environments where macroalgae were not present, coral cover was higher. However, light limitation and depth may limit A. poculata abundance, with symbiotic colonies growing no deeper than 12.5 m and only aposymbiotic colonies present from 13 to 22 m. As macroalgae abundance and turbidity increase with more nutrient loading in coastal marine ecosystems, monitoring their effect on the distribution and density of A. poculata is critical to conserve this monotypic species.
Forging common ground in second language acquisition and teaching: A combined synergy statement
Authors: Michel Marije , Atkinson Dwight , Ribeiro Amable Custodio , Alexopoulou Theodora , Cappellini Marco , Eskildsen Søren Wind , Gao Xuesong (Andy) , Hellermann John , Kayi‐Aydar Hayriye , Lowie Wander , Mejía‐Laguna Jorge Andres , Ortega Lourdes , Pekarek Doehler Simona , Sasaki Miyuki , Sato Masatoshi , Thorne Steven L. , Zheng Yongyan 
Published: February 2025

AbstractIn this final article in this guest‐edited issue on synergies in second language acquisition and teaching (SLA/T), we attempt to bring together the main content of this issue in an overall, combined synergy statement, concluding this project as a whole. Let us remind readers of the project: A shared effort by 17 scholars taking 11 different perspectives on SLA/T is not the norm in our field. Our aim has been to promote the intermingling and cross‐pollination of ideas, on the conviction that such efforts are needed to promote a field that is more than simply the sum of its parts, which are quite dispersed. In this article, we take up the challenge of synergizing the synergies. Taking into account the group synergy statements (Articles 2–4 of this guest‐edited issue), we explore those areas where we find synergies, commensurabilities, and complementary insights based on cross‐pollination among a collection of scholars representing diverse perspectives on SLA/T.
Holding together Hope and despair: Transformative learning through virtual place‐based education in Aotearoa, New Zealand
Authors: Beban Alice , Korson Cadey 
Published: February 2025

AbstractThis article explores how virtual place‐based education can foster transformative learning for distance students through a study of the Spatial Awareness Project, a digital storytelling film and podcast we co‐created with faculty and students. We found that students engaged with the resources in complex ways, with three dominant themes emerging in qualitative surveys of their emotional engagement: feeling joy, feeling unsettled, and feeling empowered. We argue that digital media that leaves students simultaneously positively affected and unsettled can enable transformative learning through discomfort, creating space for imagining the world in new ways, and sparking new conversations and connections within and outside the classroom.
The effectiveness of liposomal bupivacaine in ultrasound‐guided abdominal wall blocks after open abdominal surgery: A systematic review
Authors: Vereen Maya S. , Bidault Vincent J. , Krabbendam Elise , Hoeks Sanne E. , Stolker Robert Jan , Dirckx Maaike 
Published: February 2025

AbstractBackground and ObjectiveThoracic epidural analgesia has traditionally been used for pain management after open abdominal surgery, but its use has declined. The quest for efficient alternatives has resulted in the increasing use of regional techniques. These can be applied as single‐shot or continuous blocks using catheters. Long‐acting liposomal bupivacaine could preclude the use of catheters. This review aimed to evaluate the effectiveness of ultrasound‐guided abdominal wall blocks with liposomal bupivacaine for open abdominal surgery.Databases and Data TreatmentMedline ALL, Embase, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and Google Scholar were systematically searched. Screening, data extraction, and quality assessment were done by two independent researchers. Inclusion criteria were (1) liposomal bupivacaine in ultrasound‐guided abdominal wall blocks for open abdominal surgery, (2) outcome of pain and/or opioid consumption, (3) patients >18 years, and (4) reports published in English.ResultsOf the 1277 studies found, 22 met the inclusion criteria. The Cochrane Risk of Bias (Version 2) tool was used to assess randomized controlled trials. Studies were grouped for clarity. Transversus abdominis plane (TAP) blocks were mostly investigated. Data were heterogenic regarding types of surgery, approach to block placement, anesthetic solution injected, and use of intrathecal morphine (ITM).ConclusionsPatients undergoing cesarean section with neuraxial anesthesia and intrathecal morphine benefit from TAP blocks with liposomal bupivacaine, demonstrating reduced opioid consumption and comparable pain. Evidence for other open abdominal surgeries was inconclusive. Abdominal wall blocks with liposomal bupivacaine could be a viable alternative when epidural analgesia is contraindicated.