bluuebunny/crossref_metadata_2025_split huggingface dataset:
DLBCL with an associated IgM serum paraprotein (IgMs- DLBCL) has poor prognosis and frequent mutations in MYD88, CD79B and TP53 genes
Authors: Cox Maria Christina , Marcheselli Luigi , Scafetta Giorgia , Visco Carlo , Hohaus Stefan , Annibali Ombretta , Musuraca Gerardo , Fabbri Alberto , Cantonetti Maria , Pelliccia Sabrina , Papotti Robel , Petrucci Luigi , Tani Monica , Battistini Roberta , Arcari Annalisa , Luminari Stefano , Lopez Gianluca , Alma Eleonora , Pupo Livio , Carli Giuseppe , Marchesi Francesco , Re Francesca , Scarpino Stefania , D’amore Emanuele , Larocca Luigi M , Bianchi Antonella , Pepe Giuseppina , Natalino Fiammetta , Anticoli-Borza Paola , Cenfra Natalia , Andriani Alessandro , Abruzzese Elisabetta , Tesei Cristiano , Leoncini Lorenzo , Asioli Silvia , Ruco Luigi , Napoli Arianna Di 
Published: March 2022

Abstract
PURPOUSE: to assess the clinicopathologic features of a poorly defined subset of diffuse large b-cell lymphoma, which is characterized by the secretion of an IgM paraprotein (IgMs-DLBCL). EXPERIMENTAL DESIGN: multicentre, retrospective, and comparative study to analyse with an integrated diagnostic approach the IgMs-DLBCL subset.RESULTS: Overall, 650 DLBCL were enrolled: 102 had an associated serum IgM and 56 other paraproteins (OP), the remaining 492 cases were the reference group (REF). IgMs-DLBCL were characterized by older age, advanced stage, dissemination to extra-nodal organs, elevated LDH and poor PS. As a result, the majority of IgMs had a high IPI, NCC-IPI and CNS-IPI score (p<.001).Furthermore, IgMs qualified as an independent prognostic factor in multivariate analysis for both PFS and OS (p<.001). Remarkably, the incidence of CNS involvement was higher in the IgMs compared to the OP and the REF subsets, respectively (p<.001). IgMs-DLBCL were characterized by: 1) prevalence of non-GCB/ABC-type; 2) frequent overexpression of BCL-2; 3) preferential IGVH4-34 gene usage; 4) MYD88 and TP53 mutations, both occurringin 30.8% of IgMs cases (95%CI, 14.3-51.8) CONCLUSION: Our study was carried out on the largest series of IgMs-DLBCL reported so far. This is a sizeable subset of DLBCL (7.9%, 95%CI, 5.9-10.5%),which is worth to detect at diagnosis. Remarkably, IgMs-DLBCL harbours features of a molecular subset that associate with a worse outcome. Indeed, more studies are necessary to fully understand the molecular pathogenesis of IgMs-DLBCL and the biological mechanisms leading to the high rate of CNS spreading.
Molecular docking of substituted pyrazolone analogs targeting MAO-B as therapeutic site for Parkinson: an in-silico study
Authors: Ashtekar Harsha , Aggarwal Natasha , Fernandes Zeena , Rao Apoorva , Varghese Nimmy 
Published: March 2022

Abstract
Parkinson’s disease is considered as common age-related progressive neuronal disorder characterized by motor, sensory, and cognitive dysfunction. Current medication for PD offers only symptomatic relief but no cure. Although it is considered that these medicines can produce acute or chronic side effects, and becomes less effective over a time. Owing to this concerns, the discovery of novel molecule is of considerable interest. Depletion of dopamine is one of the major cause of PD which is regulated by Monoamines. In this regards monoamine oxidase (MAO-B) inhibitors are of great interest to combat PD. Among several known molecules Pyrazolone has been evident for the MAO-B inhibitory potential. Therefore, in the present study MAO-B is selected as a key target to examine the interaction of Pyrazolone derivatives with crystal structure of MAO-B. For this purpose, Molecular docking, Quick prop module, and Mechanics/generalized born surface area (MM-GBSA) parameters are analyzed, to evaluate Molecular interaction, Pharmacokinetic parameters, and Binding energy. Further results show that compounds attached with chloride and nitrogen group have better binding efficiency, therefore they can be selected as a promising drug candidate for the treatment of PD.
Auditory dominance in processing Chinese syntactic abnormalities in response to competing audio-visual stimuli
Authors: Pei changfu , Huang Xunan , Li Yuqin , Chen Baodan , Lu Bin , Peng Yueheng , Si Yajing , Zhang Xiabing , Zhang Tao , Yao Dezhong , Li Fali , Xu Peng 
Published: March 2022

Abstract
Language is a remarkable cognitive ability that can be expressed through visuospatial (written language) or audio-oral (spoken language) modalities. When visual characters and auditory speech exhibit conflicting features, individuals may selectively attend to a certain feature. However, the dominant modality in such a situation and the neural mechanism underlying it are both still unclear. To investigate the neural mechanism underlying audio-visual competition in Chinese, newly developed Chinese character-speech materials were presented to the study participants, and the participants' electroencephalographic (EEG) and behavioural responses were recorded. When audio-visual competition occurs, the brain more accurately recognizes meaningless speech sounds. Event-related potential (ERP) analysis showed that incongruent audio-visual stimuli induced a larger N400 amplitude than congruent audio-visual stimuli elicited. In addition, the N400 amplitude was larger in the auditory mismatch condition than in the visual mismatch condition. In terms of the brain network, compared with that in the visual mismatch condition, the dominant reconfiguration pattern in the auditory mismatch condition was the stronger linkages in the posterior occipital-parietal areas. Our research illustrates the superiority of the auditory modality over the visual modality, extending our understanding of the neural mechanisms of audio-visual competition in Chinese.
Factors Affecting the Choice of Cashless Payment in Vietnam
Authors: HO Chi H.P. , Nguyen Kiet Tuan , QUACH Tu D. 
Published: March 2022

Abstract
To study the factors affecting the choice of cashless payments, in cases where customers have a choice between cash and cashless payment, the article used data collected from surveys of 405 individuals residing in two big cities of Vietnam. The paper applied conditional logistic regression to point out the characteristics that affect the non-cash payment decision. The results show that women are more likely to use the service than men and peaking at the age of 36–40. Moreover, income level, occupation, and trust are found to have a significant association with the choice of cashless payment, thereby drawing some practical implications.
In silico identification of vaccine and drug targets for Corynebacterium ulcerans and the recently described C. silvaticum
Authors: Cerqueira Janaína Canário , Viana Marcus Vinicius Canário , Jaiswal Arun Kumar , Soares Siomar Castro , Tiwari Sandeep , Wattam Alice Rebecca , Silva Artur , Alzahrani Khalid J. , Tambuwala Murtaza M. , Barh Debmalya , Azevedo Vasco Ariston Carvalho 
Published: March 2022

Abstract
The availability of complete genomes of pathogens enables in silico analyzes that can be used to develop new control methods, reducing the time, cost, and necessity of pathogen cultivation. In this study, we developed a novel pipeline for the prediction of common broad-spectrum drug and vaccine candidates against the diphtheria toxin producing Corynebacterium ulcerans and the recently described C. silvaticum species, considered as a zoonotic potential. We found four common, non-host homologous, virulent, essential cytoplasmic druggable proteins that belong to metabolic pathways and are involved in the regulation in other essential genes. In addition, the docking analysis showed natural compounds from the ZINC database as drug candidate against the target proteins. We also identified nine vaccine candidates involved in transport and regulation of permeability of substances important to the cell. We hypothesize that these identified therapeutic targets and antimicrobial drugs could be considered for prophylaxis and hence, should be subjected to further experimental validations. We suggest that the pipeline can be used on any pathogen.
Visual Analysis of Uterine Adhesion Research Based on citespace: Bibliometric Analysis from 2006 to 2021
Authors: Ding Dou-Dou , Zuo Man-Zhen , Zhou Quan , He Ze-Xian 
Published: March 2022

Abstract
Background
Intrauterine adhesionis caused by a variety of reasons, such as damage of the endometrial basal layer, adhesion or occlusion of the uterine cavity or cervix in different degrees.Seriously endangering women's physical and mental health.
Objective
The purpose of this paper is to analyze the research development of intrauterine adhesions in recent 15 years, explore the future development direction, and promote the development of this field.
Methods
With intrauterine adhesions and Ashman's syndrome as the theme, the related literatures from January 2006 to July 2021 in the Web of Science were searched, and the visual atlas was analyzed by CiteSpace software.
Results
A total of 644 literatures were included. The key words related to intrauterine adhesion mainly include adhesion, pregnancy, expression, intrauterine adhesions, women, adhesion molecule, diagnosis, activation, hysteroscopy and fertility,etc.Six clusters were obtained by keywords analysis, involving hysteroscopy, placenta, office hysteroscopy, uterus and laparoscopy. Co-occurrence of keywords shows that the research focus in recent years is on endometrial repair and regeneration.
Conclusions
Through the bibliometric analysis of WOS research on intrauterine adhesions in recent 15 years, the comprehensive analysis of countries, institutions, authors and keywords is obtained, which has a clear guiding significance for guiding the future development of intrauterine adhesions.
Long COVID and Symptom Trajectory in a Representative Sample of Americans
Authors: Wu Qiao , Ailshire Jennifer , Crimmins Eileen 
Published: March 2022

Abstract
People who have COVID-19 can experience symptoms for months. Studies on long COVID in the population lack representative samples and longitudinal data focusing on new-onset symptoms occurring with COVID while accounting for pre-infection symptoms. We use a sample representing the U.S. community population from the Understanding America Study COVID-19 Survey, which surveyed around 8,000 respondents bi-weekly from March 2020 to March 2021. Our final sample includes 308 infected individuals who were interviewed one month before, around the time of, and 12 weeks after infection. About 23% of the sample experienced new-onset symptoms during infection which lasted for more than 12 weeks, and thus can be considered as having long COVID. The most common persistent new-onset symptoms among those included in the study were headache (22%), runny or stuffy nose (19%), abdominal discomfort (18%), fatigue (17%), and diarrhea (13%). Long COVID was more likely among obese individuals (OR = 5.44, p < 0.001) and those who experienced hair loss (OR = 6.94, p < 0.05), headache (OR = 3.37, p < 0.05), and sore throat (OR = 3.56, p < 0.05) during infection. Risk was unrelated to age, gender, race/ethnicity, education, current smoking status, or comorbid chronic conditions. This work provides national estimates of long COVID in a representative sample after accounting for pre-infection symptoms.
Sleep disturbance is associated with neck pain: a 3-year longitudinal study after the Great East Japan Earthquake
Authors: Yabe Yutaka , Hagiwara Yoshihiro , Sekiguchi Takuya , Sugawara Yumi , Tsuchiya Masahiro , Yoshida Shinichirou , Tsuji Ichiro 
Published: March 2022

Abstract
Background: Neck pain is a common health problem in the general population as well as in people after natural disasters. Sleep disturbances are gaining attention as risk factors for musculoskeletal pain; however, the association between sleep disturbance and neck pain has not been clarified. The present study aimed to clarify the association between sleep disturbance and neck pain, especially focusing on the effect of the duration of sleep disturbance. Methods: This study used 3-year longitudinal data obtained from individuals (n = 2,059) living in disaster-affected areas after the Great East Japan Earthquake. Sleep disturbance and neck pain were investigated at 4, 5, 6, and 7 years after the disaster. Multiple logistic regression analyses were used for the assessment.Results: Sleep disturbance was significantly associated with neck pain, and the association was stronger as the duration of sleep disturbance increased (adjusted odds ratios [95% confidence intervals]: 1.84 [1.23-2.75] for “<1 year”; 2.41 [1.53-3.81] for “≥1 year and <2 years”; 2.80 [2.09-3.76] for “≥2 years”). Furthermore, preceding sleep disturbance was significantly associated with the onset of neck pain, and the association was stronger as the duration of sleep disturbance increased (adjusted odds ratios [95% confidence intervals]: 1.86 [1.08-3.20] for “< 1 year”; 2.39 [1.22-4.70] for “≥ 1 year and < 2 years”; 3.00 [1.94-4.65] for “≥ 2 years”).Conclusions: Sleep disturbance is associated with neck pain, and long-lasting sleep disturbance strengthens the association. Clinicians should consider this association to effectively treat patients with neck pain.
Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein
Authors: Baringer Stephanie L. , Neely Elizabeth B. , Palsa Kondaiah , Simpson Ian A. , Connor James R. 
Published: March 2022

Abstract
Background: The brain requires iron for a number of processes, including energy production. Inadequate or excessive amounts of iron can be detrimental and lead to a number of neurological disorders. As such, regulation of brain iron uptake is required for proper functioning. Understanding both the movement of iron into the brain and how this process is regulated is crucial to both address dysfunctions with brain iron uptake in disease and successfully use the transferrin receptor uptake system for drug delivery. Methods: Using in vivo steady state infusions of apo- and holo-transferrin into the lateral ventricle, we demonstrate the regulatory effects of brain apo- and holo-transferrin ratios on the delivery of radioactive 55Fe bound to transferrin or H-ferritin in male and female mice. In discovering sex differences in the response to apo and holo Tf infusions, ovariectomies were performed on female mice to interrogate the influence of circulating estrogen on regulation of iron uptake. Results: Our model reveals that both sex and type of iron delivery protein have significant effects on the regulation of iron uptake into the microvasculature and subsequent release into the brain. Furthermore, we show that cells of the microvasculature act as significant reservoirs of iron and release the iron in response to cues from the interstitial fluid of the brain. Conclusions: These findings extend our previous work to demonstrate that the regulation of brain iron uptake is influenced by both the mode in which iron is delivered and sex. These findings further emphasize the role of the microvasculature in regulating brain iron uptake and the importance of cues regarding iron status in the extracellular fluid.
First-principles study on the physical properties of monoclinic MgCO 3 under high pressure
Authors: Liu Zi-Jiang , Sun Xiao-Wei , Zhang Cai-Rong , Zhang Shun-Jing , Zhang Zheng-Rong , Jin Neng-Zhi 
Published: March 2022

Abstract
The first-principles calculations based on density functional theory with projector-augmented wave are used to study the physical properties of monoclinic MgCO3 at lower mantle conditions. The results show that the phase transition pressure of rhombohedral MgCO3(magnesite) to monoclinic MgCO3 is between 72–79 GPa in the temperature range of the mantle. The equation of state for monoclinic MgCO3 agrees well with recent experimental results. The elastic constants of monoclinic MgCO3 are consistent with the latest theoretical results. The elastic modulus of monoclinic MgCO3, especially its shear modulus, exhibits a nonlinear pressure dependence, leading to a significant nonlinear pressure dependence of the small elastic anisotropy and the small wave velocity anisotropy, which is why carbide minerals may not be detected in the deep mantle. The thermodynamic properties of monoclinic MgCO3 at high temperature and high pressure are predicted using the Debye-Grüneisen model.
Performance assessment for earthquake-damaged RC structure based on damaged section analysis
Authors: Ma Juntao , Wang Guoxin 
Published: March 2022

Abstract
Evaluating quantitatively the performance of earthquake-damaged structures is significant for facilitating post-earthquake reconstruction. However, it is difficult to consider the effect of earthquake-induced damage on structure. In this paper, a new method to build earthquake-damaged structure model (EDSM) based on damaged cross section analysis (DSA) procedure is proposed. DSA can consider the effect of earthquake-induced damage on concrete and reinforcement, respectively, and determine the skeleton curve of damaged cross section. EDSM is constructed by replacing plastic hinges of structure after earthquake with trilinear skeleton curve computed by DSA. This method is realized on RC frame structure and verified by the comparison of response between undamaged structure under sequence ground motions and EDSM under the last ground motion. Subsequently, there is more prominent reduction on the vulnerability of slight limit state than higher limit states by comparing the fragility of undamaged structure and EDSM. It can be indicated that earthquake-induced damage has more significant effect on elastic properties of structure. The proposed method to establish EDSM can well represent the structure after earthquake and assess quantitatively residual performance of earthquake-damaged structure and provide a reference for reconstruction decisions.
Hydroxyproline as a New Biomarker to Differentiate Osteoarthritis from Rheumatoid Arthritis in the Early Stages.
Authors: Elbeialy Adel , Elabd Hemmat , Shahen Amira , Amin Radwa 
Published: March 2022

Abstract
Background: Osteoarthritis (OA) and rheumatoid arthritis (RA) are the most common inflammatory disorders of the musculoskeletal system which are defined by articular cartilage degradation and impairment of joints. When criteria and radiography are insufficient to diagnose the early stages of RA and OA to control disease course, biomarkers become necessary to early diagnose these diseases. Objective: We searched the levels of (MMP3) and (HP) in the blood of early RA and OA patients in order to see if they can be utilized to distinguish the two diseases at an early stage. Patients and Methods: We recruited 1) forty patients who were diagnosed with early knee osteoarthritis using EULAR and Kellgren-Lawrence radiographic grading criteria, 2) forty patients with early RA (disease duration less than three years), and 3) forty control groups consisted of normal volunteers who were age and sex-matched. All subjects underwent a thorough medical history, clinical musculoskeletal examination, and laboratory tests, including the determination of blood MMP3 and HP. We did also a simple x-ray of their hands and knee joints. Results: Comparing groups, we found a highly significant increase in serum MMP3 in OA patients than RA patients and control groups. MMP3 was also significantly higher in RA patients than in the control group. While, OA patients had significantly higher HP than RA patients and control groups, whereas RA patients and control groups had no significant difference in HP. Conclusion: Hydroxyproline rather than MMP3 may be employed as a potential biomarker for early differentiation between osteoarthritis and rheumatoid arthritis.
Utilization of Long –Acting Contraceptive Methods and Associated Factor Among Female Health Care Providers in South Wollo Zone Hospitals, North East, Ethiopia.
Authors: seid Mehdi , Yimer Aragaw , seid Ahmed , Fantaye Fasil , Damtie Yitayshi 
Published: March 2022

Abstract
Back ground: - Long-acting contraception method utilization was found low (22.7%) among female health care providers. However, as far as my literature search no study was done on long-acting contraception methods utilization among female health providers in the study area. These studies failed to include important variable like socio demography and individual factor which might affect the use of long-acting contraceptive methods female health providers and limited studies in Ethiopia. Objective: - To assessing utilization of long -acting contraceptive methods and associated factors among health care providers in south wollo zone public hospitals, Amhara region, Ethiopia 2021.Methods: -An Institutional-based cross- sectional was conducted among 354 female health care workers in south wollo zone hospitals, from March to April 22, 2021. The participants were selected using Systematic random sampling technique. Data were collected by using self-administered questionnaire. The data were entered Epi-data version 4.1 and export to SPSS versions 25 for analysis. Bivariable and multivariable logistic regression analysis were performed. The Adjusted odds Ratio (AOR) along with a 95% confidence interval (CI) was estimated to measure the association and level of significance was declared at a P- value of less than 0.05.Result: -The current utilization of long-acting contraceptive methods among female health care providers was found to be 33.6% [95%, CI 29-39)], discuss with partner [AOR= 2.277,95% CI, (1.026-5.055)], method shift/switched [AOR=4.302,95% CI, (2.285-8.102)], knowledge of respondent [AOR= 1.887,95% CI, (1.020-3.491)], ever birth [AOR=15.670,95% CI, (5.065-48.49)] were significant factors towards the utilization of long-acting contraceptive methods. Conclusion and recommendation: -The current utilization of long-acting contraceptive methods was found low. Discus with partner, methods shift/switching, ever birth and knowledge of respondents were identified as significant factor. Therefore, encouraging partner discussion targeted Information Education Communication Intervention should be intensified to improve long-acting contraceptive methods utilization.
A New Method of Generating Life-Time Distributions
Authors: Riffi Mohamed I. 
Published: March 2022

Abstract
Abstract. Statisticians are interested in improving the ability of classical distributions to appropriately fit real-world data and accurately describe its characteristics. Typically, this can be achieved by extending known distributions by incorporating extra parameters or compounding distributions. In this paper, a flexible general method to obtain new families of distributions is proposed. A number of known methods turn out to be special cases of the proposed method in this paper. Some examples are given to demonstrate the power of the proposed method such as the exponential and the Weibull distribution.