bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Failure of Removal of the Urinary Catheter for Patients With Intracerebral Hemorrhage Postoperatively
Authors: Zhou E. , He Jin-Ai , Liu Ling , Wang Jing , Ding Wei-Long 
Published: February 2022

Background:
We conducted this study to assess the value of clinically relevant data for predicting the failure of removing urinary catheters among patients with intracerebral hemorrhage postoperatively.

Materials and Methods:
We retrospectively analyzed the medical records of all patients with intracerebral hemorrhage who underwent surgery for removal of intracerebral hematoma between January 2014 and December 2019, all of whom retained their urinary catheter. The patients were classified into 2 groups. Group A included patients who underwent successful removal of the catheter while group B included patients who underwent a failed removal. Univariate analysis was performed to determine the relationship between the failure of catheter removal and the patients’ preoperative clinical characteristics. Independent prognostic predictors were identified using multivariate analyses.

Results:
The site of intracerebral hematoma (P=0.004), volume of hematoma (P<0.001), intraventricular hemorrhage (P<0.001), admitted Glasgow Coma Scale (GCS) (P<0.001), GCS before urinary catheter removal (P<0.001), smoking (P=0.011), herniation (P<0.001), urine protein (P=0.013), creatinine (P=0.037), and timing of urinary catheter removal (P<0.001) were significantly different among the 2 groups. Multiple logistical regression analysis indicated that GCS before urinary catheter removal (odds ratio=1.171; 95% confidence interval=1.050-1.306; P=0.005) and timing for urinary catheter removal (odds ratio=0.962; 95% confidence interval=0.944-0.981; P<0.001) were associated with failure of urinary catheter removal.

Conclusions:
This study demonstrated that GCS before urinary catheter removal and the timing of urinary catheter removal are independent factors associated with failure of urinary catheter removal among patients with intracerebral hemorrhage.
Associations With Extubation Failure and Predictive Value of Risk Analytics Algorithms With Extubation Readiness Tests Following Congenital Cardiac Surgery
Authors: Hames Daniel L. , Sleeper Lynn A. , Bullock Kevin J. , Feins Eric N. , Mills Kimberly I. , Laussen Peter C. , Salvin Joshua W. 
Published: February 2022

OBJECTIVES:
Extubation failure is associated with morbidity and mortality in children following cardiac surgery. Current extubation readiness tests (ERT) do not consider the nonrespiratory support provided by mechanical ventilation (MV) for children with congenital heart disease. We aimed to identify factors associated with extubation failure in children following cardiac surgery and assess the performance of two risk analytics algorithms for patients undergoing an ERT.

DESIGN:
Retrospective cohort study.

SETTING:
CICU at a tertiary-care children’s hospital.

PATIENTS:
Children receiving MV greater than 48 hours following cardiac surgery between January 1, 2017, and December 31, 2019.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Six hundred fifty encounters were analyzed with 49 occurrences (8%) of reintubation. Extubation failure occurred most frequently within 6 hours of extubation. On multivariable analysis, younger age (per each 3-mo decrease: odds ratio [OR], 1.06; 95% CI, 1.001–1.12), male sex (OR, 2.02; 95% CI, 1.03–3.97), Society of Thoracic Surgery-European Association for Cardiothoracic Surgery category 5 procedure (p equals to 0.005), and preoperative respiratory support (OR, 2.08; 95% CI, 1.09–3.95) were independently associated with unplanned reintubation. Our institutional ERT had low sensitivity to identify patients at risk for reintubation (23.8%; 95% CI, 9.7–47.6%). The addition of the inadequate delivery of oxygen (IDO2) index to the ERT increased the sensitivity by 19.0% (95% CI, –2.5 to 40.7%; p = 0.05), but the sensitivity remained low and the accuracy of the test dropped by 8.9% (95% CI, 4.7–13.1%; p < 0.01).

CONCLUSIONS:
Preoperative respiratory support, younger age, and more complex operations are associated with postoperative extubation failure. IDO2 and IVCO2 provide unique cardiorespiratory monitoring parameters during ERTs but require further investigation before being used in clinical evaluation for extubation failure.
Doctor of Physical Therapy Students' Perceptions of Engagement in Service Learning With Scouts: A Descriptive Study
Authors: Arena Sara K. , Heeg Samantha , Lewis Austin , Matero Erica 
Published: February 2022

Purpose:
To describe doctor of physical therapy (DPT) students' perceptions following their engagement in a health promotion and wellness service-learning event (SLE) with boy scouts.

Methods:
A descriptive study using a sample of convenience examined engagement in an SLE with adolescents. Reflective journals summarized student experiences with the population, confidence in executing a fitness examination and motivational interviewing (MI), and anticipated challenges and benefits before and after the SLE. Journals were analyzed for themes and associated frequencies.

Results:
Pre-event themes included expected communication challenges, a mutually beneficial SLE, and increased competency with the population, fitness testing, and MI. Post-event themes included communication barriers not realized, unexpected challenges, and increased confidence with the population, fitness testing, and MI.

Conclusion:
Engaging with adolescents in SLEs provides DPT students with skills and confidence for future clinical practice. See the Digital Abstract (available: at: http://links.lww.com/PPT/A347).
The Short-term Effects of Hippotherapy and Therapeutic Horseback Riding on Spasticity in Children With Cerebral Palsy: A Meta-analysis
Authors: Hyun Cheolhwan , Kim Kyungmin , Lee Soolim , Ko Nayeon , Lee In-Sik , Koh Seong-Eun 
Published: February 2022

Purpose:
We systematically reviewed the short-term effects of hippotherapy and therapeutic horseback riding (THR) on lower-limb muscle spasticity in children with cerebral palsy (CP).

Methods:
PubMed, EMBASE, Cochrane Library, and Google Scholar databases were searched for relevant quantitative studies. Treatment effects were coded using the Ashworth scale (AS) or modified Ashworth scale (MAS) in pre- and posttreatment evaluations. Of the 73 studies identified initially, 7 met the inclusion criteria.

Results:
Treatment was associated with positive effects on lower-limb muscle spasticity, as supported by the AS or MAS scores. However, repeated trials did not show a statistically significant difference from a single trial (Q = 2.95, P = .086).

Conclusion:
Hippotherapy and THR can be used to treat lower-limb muscle spasticity in children with CP. However, repeated sessions did not show a better effect in reducing spasticity.

What this adds to the evidence:
This is the first meta-analysis to confirm that hippotherapy or THR can reduce lower-limb muscle spasticity in children with CP in the short term, but long-term effects on function still require further studies.
Facial Gender Confirmation Surgery: The Lower Jaw. Description of Surgical Techniques and Presentation of Results
Authors: Simon Daniel , Capitán Luis , Bailón Carlos , Bellinga Raúl J. , Gutiérrez-Santamaría Javier , Tenório Thiago , Sánchez-García Anabel , Capitán-Cañadas Fermín 
Published: February 2022

Background:
Of the primary procedures associated with facial gender confirmation surgery, those involving the mentomandibular complex have received the least attention in the literature.

Methods:
The authors present their experience with 837 trans feminine patients operated on for facial gender confirmation surgery who underwent mandibular bone contouring procedures, including bone contouring, chin and mandibular body and angle ostectomies, and osteotomies to reposition the chin. The authors describe the surgical techniques and materials used, and present a customized lower border–supported cutting guide designed by their team and used with 205 patients. A femininity perception score was calculated preoperatively and 12 months postoperatively, and satisfaction with the results was measured 12 months postoperatively.

Results:
The postoperative follow-up ranged from 12 to 110 months. The mean femininity perception score increased from 47.86 preoperatively to 76.41 at 12 months postoperatively (p < 0.001). No emergency surgical operations were required. In no case was there any permanent damage to the mental or inferior dental nerve. The reoperation percentage because of problems detected during the postoperative period was 2.63 percent (22 patients).

Conclusions:
With facial gender confirmation surgery of the jawline and chin, it is possible to modify the transverse and vertical components of the jaw; soften the gonial angles; change the format, bone volume, and position of the chin; and harmonize the entire mandibular line. The facial feminization achieved high satisfaction scores regarding the results and feminine gender appearance 12 months after surgery. The future of mandibular bone contouring techniques includes planning with virtual software and surgical support with patient-specific cutting guides.
Automatic Real-Time Space Registration Application for Simulating Dental and Maxillofacial Surgery
Authors: Bai Sifan , Liao Shenghui , Han Fuchang , Peng Xinyu , Li Zhilin , Yang Weipeng , Wu Renzhong 
Published: February 2022

Abstract:
Real-time surgical navigation systems are important for preoperative planning and intraoperative navigation. Automatic preoperative multimodal data registration and postoperative spatial registration are extremely crucial in such surgical navigation systems. However, existing automatic multimodal data registration methods have extremely limited application scope due to the lack of accuracy and speed. In addition, the registration results obtained by existing methods are practically lacking and are rarely applied in clinics. To address the above issues, this paper proposes a novel real-time teeth registration algorithm with computed tomography (CT) data and optical tracking scanning data. The proposed method is based on the weighted iterative closest point (ICP) algorithm with 3 improvements: (1) the multilayer spherical point set is generated inside the laser scanning marker sphere, (2) the weight decreases from inside to outside layer by layer, and (3) the weight of the voxel center point set is combined with the CT data of the marker sphere. Specifically, the proposed iCP registration method can overcome the limitation of surface point set registration and tackle the problem of high surface deformity of laser scanning marker spheres. For the registration result of CT and scanning data, the authors employ the real-time spatial registration algorithm based on optical tracking to complete the navigation of the simulated surgical instruments on the multimodal fusion image. The experimental results show that the proposed ICP algorithm reduces the mean square error by 1 order of magnitude and that our method has strong practical value.
Outcomes in Pediatric Maxillofacial Reconstruction With Vascularized Fibular Flaps: A Systematic Review
Authors: Cho Annie M. , Lopez Joseph , Teven Chad M. , Pourtaheri Navid , Do Nicholas T.K. , Jazayeri Hossein E. , Steinbacher Derek M. , Blackwell Keith E. , Ozaki Wayne , Yu Jason W. 
Published: February 2022

Background:
The purpose of this study was to examine the complications and outcomes after maxillofacial reconstruction using the free fibular flap in the pediatric population.

Methods:
A systematic review and descriptive analysis were conducted using data variables, including study characteristics; patient characteristics; postoperative complications (major and minor); surgical revision; and dental rehabilitation.

Results:
The systematic review resulted in 1622 articles, 55 of which met inclusion criteria for this study. The 55 articles consisted of 17 case series and 38 case reports with level III/IV and level V of evidence, respectively. Of the 155 identified pediatric patients, the rate of major complications was 13.5% and minor complications was 24.5%. The most common complication was mild growth distortion (n = 7) at the recipient site. Complications at the donor site were less common. During follow-up, 29 patients (18.7%) underwent or awaited surgical revision, and 43 patients (27.7%) underwent or awaited dental rehabilitation.

Conclusions:
Our study suggests that the free fibular flap for pediatric maxillofacial reconstruction is safe and reliable. Additionally, surgical revision to correct the functional impairments resulting from primary reconstruction using the free fibular flap is relatively common.
Surgical Treatment of Parapharyngeal Space Salivary Gland Tumor
Authors: Shin Bong Jin , Lee Dong Hoon , Lee Joon Kyoo , Lim Sang Chul 
Published: February 2022

Introduction:
Parapharyngeal space salivary gland tumors are very rare. The authors sought to examine the clinical features, treatment methods, and treatment results of parapharyngeal space salivary gland tumors in our hospital.

Methods:
The authors retrospectively enrolled 15 patients who were finally diagnosed as having parapharyngeal space salivary gland tumors from January 2010 to January 2021.

Results:
All parapharyngeal space salivary gland tumors arose from the prestyloid compartment. This study included 3 males and 12 females. The main symptoms were incidental diagnosis during imaging tests, followed by neck discomfort, oral mass, neck mass, and headache. Surgical methods for parapharyngeal space salivary gland tumors were performed in the following order: transcervical approach (n = 10), transcervical-parotid approach (n = 3), transoral approach (n = 1), and transparotid approach (n = 1). Pleomorphic adenoma was the most common tumor among parapharyngeal space salivary gland tumors.

Conclusions:
In the surgery of parapharyngeal space salivary gland tumors, a transcervical or transcervical-parotid approach was mainly used by predicting the origin site through radiologic examinations.
Medial Epicanthoplasty With the Classic and Modified Skin Redraping Method: A Retrospective Case Control Study
Authors: Huang Jiuzuo , Wang Hefei , Du Fengzhou , Long Xiao , Liu Zhigang 
Published: February 2022

Abstract:
The skin redraping method for medial epicanthoplasty is characterized by some shortcomings which warrants modification. In this study, clinical data of 193 patients who underwent medial epichanthoplasty by the modified skin redraping technique or the classic skin redraping technique were reviewed retrospectively. The patients underwent operation between May 2018 and June 2020 and were followed up for not less than 6 months. Interepicanthal distance, interpupillary distance, patient satisfaction, and postoperative complications were evaluated. In terms of interepicanthal distance/inter-pupillary distance ratio (P > 0.05) and satisfaction score (P = 0.759), the modified skin redraping technique and the classic skin redraping technique were similar. In the classic skin redraping group, there were 3 cases of visible scarring in the lower eyelid, corresponding to significantly more cases than in the modified skin redraping group (n = 0, P < 0.001). There were more out-fold cases in the modified skin redraping group (76/90) than in the classic skin redraping group (17/88) (P < 0.001). Utilizing the modified skin redraping medial epicanthoplasty can prevent medial hooding of the upper eyelid, reduce the probability of visible scarring, and produce more out-fold with concurrent double eyelidplasty compared with classic skin redraping epicanthoplasty. Level of evidence: IV
Genotypic variation and plasticity in climate-adaptive traits after range expansion and fragmentation of red spruce (Picea rubensSarg.)
Authors: Prakash Anoob , DeYoung Sonia , Lachmuth Susanne , Adams Jacquelyne L. , Johnsen Kurt , Butnor John R. , Nelson David M. , Fitzpatrick Matthew C. , Keller Stephen R. 
Published: February 2022

Shifting range limits are predicted for many species as the climate warms. However, the rapid pace of climate change will challenge the natural dispersal capacity of long-lived, sessile organisms such as forest trees. Adaptive responses of populations will, therefore, depend on levels of genetic variation and plasticity for climate-responsive traits, which likely vary across the range due to expansion history and current patterns of selection. Here, we study levels of genetic and plastic variation for phenology and growth traits in populations of red spruce (Picea rubens), from the range core to the highly fragmented trailing edge. We measured more than 5000 offspring sampled from three genetically distinct regions (core, margin and edge) grown in three common gardens replicated along a latitudinal gradient. Genetic variation in phenology and growth showed low to moderate heritability and differentiation among regions, suggesting some potential to respond to selection. Phenology traits were highly plastic, but this plasticity was generally neutral or maladaptive in the effect on growth, revealing a potential liability under warmer climates. These results suggest future climate adaptation will depend on the regional availability of genetic variation in red spruce and provide a resource for the design and management of assisted gene flow.This article is part of the theme issue ‘Species’ ranges in the face of changing environments (Part II)’.
The use of hippocampal grading as a biomarker for early MCI
Authors: Morrison Cassandra , Dadar Mahsa , Shafiee Neda , Collins D. Louis ,   Alzheimer’s Disease Neuroimaging Initiative
Published: February 2022

AbstractINTRODUCTIONChanges in the hippocampus are associated with both increased age and cognitive decline due to mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Most studies have examined the association between hippocampal changes and episodic memory, with many reporting a relationship between hippocampal measurements and global cognition. However, these studies often find associations only in the later stages of cognitive decline. The goal of this study was to examine if hippocampal grading is associated with global cognition in cognitively normal controls (NC), early MCI (eMCI), late (lMCI), and AD, and whether such associations differ across diagnostic cohorts.METHODSData from 1620 Alzheimer’s Disease Neuroimaging Initiative older adults were examined in this study (495 NC, 262 eMCI, 545 lMCI, and 318 AD). Participants were included if they completed baseline MRI scans and the Alzheimer’s disease Assessment Scale (ADAS-13) and Clinical Dementia Rating – Sum of Boxes (CDR-SB) cognitive tests. Linear regressions examined the influence of hippocampal grading on cognitive scores.RESULTSLower global cognition (i.e., increased ADAS-13 scores) was associated with hippocampal grading scores in all cohorts, including normal controls. Lower global cognition (i.e., increased CDR-SB scores) was associated with hippocampal grading scores in lMCI and AD, but not in eMCI or NC groups.DISCUSSIONThese findings suggest that hippocampal grading is associated with changes in global cognition in NC, eMCI, lMCI, and AD depending on the cognitive test. Thus, hippocampal grading may be a useful measure that is sensitive to progressive changes early in the disease course.
Clinical activity of MAPK targeted therapies in patients with non-V600 BRAF mutant tumors
Authors: Dankner Matthew , Wang Yifan , Fazelzad Rouhi , Johnson Benny , Nebhan Caroline A. , Dagogo-Jack Ibiayi , Myall Nathaniel J. , Richtig Georg , Bracht Jillian W. P , Gerlinger Marco , Shinozaki Eiji , Yoshino Takayuki , Kotani Daisuke , Fangusaro Jason R. , Gautschi Oliver , Mazieres Julien , Sosman Jeffrey A. , Kopetz Scott , Subbiah Vivek , Davies Michael A. , Groover Anna , Sullivan Ryan J. , Flaherty Keith T. , Johnson Douglas B. , Benedetti Andrea , Cescon David W. , Spreafico Anna , Zogopoulos George , Rose April A. N. 
Published: February 2022

AbstractPurposeNon-V600 mutations comprise approximately 35% of all BRAF mutations in cancer. Many of these mutations have been identified as oncogenic drivers in a wide array of cancer types and can be classified into three Classes according to molecular characteristics. Consensus treatment strategies for Class 2 and 3 BRAF mutations have not yet been established.MethodsWe performed a systematic review and meta-analysis of individual patient data to assess treatment outcomes with FDA-approved mitogen activated protein kinase pathway (MAPK) targeted therapy according to BRAF Class, cancer type and MAPK targeted therapy type. A search was conducted on literature from 2010-2021. Individual patient data was collected and analyzed from published reports of patients with cancer harboring Class 2 or 3 BRAF mutations and who received MAPK targeted therapy with available treatment response data. Co-primary outcomes were response rate (RR) and progression-free survival (PFS).Results18167 studies were screened, identifying 80 studies with 238 patients that met inclusion criteria. This included 167 patients with Class 2 and 71 patients with Class 3 BRAF mutations. Overall, 77 patients achieved a treatment response. In both univariate and multivariable analyses, RR and PFS were higher among patients with Class 2 compared to Class 3 mutations, findings that remain when analyses are restricted to patients with melanoma or lung primary cancers. MEK +/- BRAF inhibitors demonstrated greater clinical activity in Class 2 compared to Class 3 BRAF mutant tumors than BRAF or EGFR inhibitors.ConclusionsThis meta-analysis suggests that MAPK targeted therapies have clinical activity in some Class 2 and 3 BRAF mutant cancers. BRAF Class may dictate responsiveness to current and emerging treatment strategies, particularly in metastatic melanoma and lung cancers. Together, this analysis provides clinical validation of predictions made based on a mutation classification system established in the preclinical literature. Further evaluation with prospective clinical trials is needed for this population.