bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship Between Job Burnout and Depressive Symptoms Among Chinese Firefighters
Authors: Cui Lei , Huang Ning , Bai Yashuang , Fu Mingqi , Zia Sidra , Guo Jing 
Published: June 2022

Objectives
This study aims to investigate the association between job burnout and depressive symptoms among Chinese firefighters, assuming colleagueship to play a moderating role in the aforementioned relationship.

Methods
This study is based on an online survey recruiting 1328 Chinese male firefighters from July 1 to August 31, 2021. Multiple linear regressions were used to examine the associations.

Results
This study revealed that all dimensions of job burnout were associated with worse depressive symptoms. Cynicism (β = 0.30; 95% confidence interval [CI], 0.236, 0.356) had the strongest association with depressive symptoms, followed by emotional exhaustion and inefficacy. Moreover, firefighters with better affective colleagueship (β = −0.10; 95% CI, −0.141, −0.061) and better obligatory colleagueship (β = −0.07; 95% CI, −0.115, −0.034) were less likely to have depressive symptoms when confronted with job burnouts.

Conclusions
This study suggests employers and practitioners should target their intervention efforts at both job burnout and colleagueship.
Addressing Mental Health Factors to Improve Outcomes in Work-Related COVID-19
Authors: LeGoff Daniel B. , Lazarovic Jacob , Kofeldt Miranda , Ghayal Hiren , Peters Aimee 
Published: June 2022

Objective
This retrospective study investigated the benefits of adding psychological services for frontline workers with delayed recovery from COVID-19 due to psychosocial stressors and/or mental disorders.

Methods
Both standardized psychological evaluation and at least 3 sessions of work-focused cognitive behavioral therapy were provided to 103 participants. Benefits were assessed by comparing the pretreatment and posttreatment recovery, work status, and self-ratings of work-related and adaptive daily functioning.

Results
Duration of recovery and return to work were reduced along with improvements in work relevant (40%) and adaptive functioning (31%). The majority (80%) returned to work within 12 weeks despite variable presenting problems, course of illness, demographic, and job factors.

Conclusions
Brief work-focused cognitive behavioral therapy seems to be an effective adjunct to customary outpatient medical care for COVID-19 in frontline essential workers for whom the return-to-work process may be negatively affected by stress, anxiety, and depressed mood.
Anemia, Weight Status, and Fatigue Among Farmworkers in California
Authors: Olivares Leslie V. , Engle-Stone Reina , Arnold Charles D. , Langer Chelsea E. , Schenker Marc B. 
Published: June 2022

Objective
This study aimed to determine the prevalence of anemia and overweight/obesity and assess the relationships between hematocrit (Hct) and body mass index (BMI), and between fatigue and Hct, among a sample of farmworkers in California.

Methods
We estimated the prevalence of anemia (using Hct), overweight/obesity (BMI ≥25 kg/m2), and self-reported fatigue in 587 farmworkers. Multivariable linear and logistic regression models were used to examine the associations between Hct and BMI, and between fatigue and Hct.

Results
Anemia prevalence was 3.1%, overweight/obesity prevalence was 80.7%, and 78% of workers reported fatigue at work. There was no association between Hct and BMI or between Hct and reported fatigue. Women were more likely than men to have lower Hct and higher BMI.

Conclusions
A majority of farmworkers in this sample were overweight/obese, but anemia was uncommon. Anemia among more vulnerable subgroups of farmworkers should be explored.
Papillary renal cell carcinoma: current and controversial issues
Authors: Angori Silvia , Lobo João , Moch Holger 
Published: June 2022

Purpose of the review
Papillary renal cell carcinoma (pRCC) is the second most frequent renal cancer subtype and represents 15–20% of all RCC. Classification of pRCC is changing because novel tumour entities have been discovered in the last years. In this review, we summarise recent studies relevant for the understanding of the molecular complexity and the broader differential diagnosis of pRCC.

Recent findings
It has been 25 years ago, that pRCC was morphologically subdivided into type 1 and type 2. Recently described tumour entities in the 2022 WHO classification challenged this concept and allow a new view on the molecular background in pRCC. Biphasic hyalinizing psammomatous RCC and papillary renal neoplasm with reversed polarity are emerging tumour entities derived from the new concept of molecularly defined RCC subtypes. Immune checkpoint inhibition and tyrosine kinase inhibitors have been introduced as the new backbone in the first-line treatment of advanced pRCCs. To identify novel targeted treatments for patients with pRCC it is crucial to investigate the specific molecular background of pRCC considering emerging pRCC subtypes.

Summary
In the future, a deeper understanding of the correlation between molecular aberrations and new pRCC subtypes may improve the classification of pRCC patients and could reveal potential predictive biomarkers for each subgroup.
Advances in ureteral stent technology
Authors: Mawhorter Michael , Streeper Necole M. 
Published: June 2022

Purpose of review
Ureteral stents are an invaluable tool for urologists but suffer from several drawbacks, including: limited durability due to stent encrustation, significant morbidity from bothersome urinary symptoms, pain and infection, risk of the forgotten stent and costly removal. This review highlights key advances in ureteral stent technology that seek to address these issues.

Recent findings
Over the past 2 years clinical trials have brought ureteral stent technology aimed to reduce stent-associated morbidity closer to clinical application. Stent material and changes to stent design show promise in improving patient tolerability without increasing complications. Low-tech innovations such as magnetic and catheter snare removal may quickly reduce costs. Radical advances such as biodegradable stent materials remain in preclinical models but show promise for eliminating the need for stent removal.

Summary
The ideal ureteral stent does not currently exist in clinical practice. This review highlights key studies that have advanced ureteral stent technology in the past 2 years.
Management of Gastroesophageal Reflux Disease in Esophageal Atresia Patients: A Cross-Sectional Survey amongst International Clinicians
Authors: van Lennep Marinde , Gottrand Frederic , Faure Christophe , Omari Taher I. , Benninga Marc A. , van Wijk Michiel P. , Krishnan Usha 
Published: June 2022

Objectives:
After surgical repair, up to 70% of esophageal atresia (EA) patients suffer from gastroesophageal reflux disease (GERD). The ESPGHAN/NASPGHAN guidelines on management of gastrointestinal complications in EA patients were published in 2016. Yet, the implementation of recommendations on GERD management remains poor.
We aimed to assess GERD management in EA patients in more detail, to identify management inconsistencies, gaps in current knowledge, and future directions for research.

Methods:
A digital questionnaire on GERD management in EA patients was sent to all members of the ESPGHAN EA working group and members of the International network of esophageal atresia (INoEA).

Results:
Forty responses were received. Thirty-five (87.5%) clinicians routinely prescribed acid suppressive therapy for 1–24 (median 12) months. A fundoplication was considered by 90.0% of clinicians in case of refractory GERD with persistent symptoms despite maximal acid suppressive therapy and in 92.5% of clinicians in case of GERD with presence of esophagitis on EGD. Half of clinicians referred patients with recurrent strictures or dependence on transpyloric feeds. Up to 25.0% of clinicians also referred all long-gap EA patients for fundoplication, those with long-term need of acid suppressants, recurrent chest infections and feedings difficulties.

Conclusions:
Respondents’ opinions on the optimal duration for routine acid suppressive therapy and indications for fundoplication in EA patients varied widely. To improve evidence-based care for EA patients, future prospective multicenter outcome studies should compare different diagnostic and treatment regimes for GERD in patients with EA. Complications of therapy should be one of the main outcome measures in such trials.
Systematic Review and Guidelines for Perioperative Management of Pediatric Patients Undergoing Major Plastic Surgery Procedures, with a Focus on Free Tissue Transfer
Authors: Mountziaris Paschalia M. , Rudolph Christina M. , Fournier Craig T. , Haykal Siba , Ricci Joseph A. , Rezak Kristen M. , Patel Ashit 
Published: June 2022

Background:
Microsurgical free tissue transfer has been successfully implemented for various reconstructive applications in children. The goal of this study was to identify the best available evidence on perioperative management of pediatric patients undergoing free tissue transfer and to use it to develop evidence-based care guidelines.

Methods:
A systematic review was conducted in the PubMed, Embase, Scopus, and Cochrane Library databases. Because a preliminary search of the pediatric microsurgical literature yielded scant data with a low level of evidence, pediatric anesthesia guidelines for healthy children undergoing major operations were also included. Exclusion criteria included vague descriptions of perioperative care, case reports, and studies of syndromic or chronically ill children.

Results:
Two hundred four articles were identified, and 53 met inclusion criteria. Management approaches specific to the pediatric population were used to formulate recommendations. High-quality data were found for anesthesia, analgesia, fluid administration/blood transfusion, and anticoagulation (Level I Evidence). Lower quality evidence was identified for patient temperature (Level III Evidence) and vasodilator use (Level IV Evidence). Key recommendations include administering sevoflurane for general anesthesia, implementing a multimodal analgesia strategy, limiting preoperative fasting, restricting blood transfusions until hemoglobin level is less than 7 g/dl unless the patient is symptomatic, and reserving chemical venous thromboembolism prophylaxis for high-risk patients.

Conclusions:
Pediatric-specific guidelines are important, as they acknowledge physiologic differences in children, which may be overlooked when extrapolating from adult studies. These evidence-based recommendations are a key first step toward standardization of perioperative care of pediatric patients undergoing plastic surgical procedures, including free tissue transfer, to improve outcomes and minimize complications.
Real-Time Assessment of Free Flap Capillary Circulation Using Videocapillaroscopy
Authors: Matsui Chihiro , Lao William W. , Tanaka Takakuni , Tsuji Nao , Matsui Yuki , Orgun Doruk , Sugawara Yasushi , Mizuno Hiroshi 
Published: June 2022

Background:
Free tissue transfer is a common method of reconstruction for various surgical defects. Many clinical assessment methods, including flap color monitoring and capillary refill time measurements, are commonly used to assess the microcirculation of the flap, yet there is no objective tool available that can clear real-time visualization of the flap microcirculation. The purpose of this study was to use a novel videocapillaroscope to evaluate the circulation changes on free flap skin surfaces while purposely clamping pedicle vessels.

Methods:
Ten patients who underwent free flap transfer for head and neck cancer from November of 2019 to June of 2020 were included in the study. Videocapillaroscopic observation was performed after flap elevation, and changes in the flap skin capillary circulation with artery-controlled and vein-controlled clamping were recorded.

Results:
Average total surgery time was 517.91 minutes (SD, 73.3 minutes), average flap elevation time was 102.9 minutes (SD, 18.3 minutes). When the pedicle artery or vein was purposely clamped, the movement of red blood cells in blood vessels stopped; when clamps were removed after 60 seconds, the restoration of red blood cell movements was rapidly observed. When the pedicle artery was clamped, the number of visualizable blood vessels decreased and flap color became relatively white. When the pedicle vein was clamped, the number of visualizable blood vessels increased, and flap color tone had a tendency toward red.

Conclusion:
Novel videocapillaroscopy can be utilized for objective real-time flap monitoring by directly visualizing flap skin capillary microcirculation.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, V.
Is calcitonin gene-related peptide a reliable biochemical marker of migraine?
Authors: Tesfay Betel , Karlsson William Kristian , Moreno Rogelio Dominguez , Hay Debbie L. , Hougaard Anders 
Published: June 2022

Purpose of review
The aim of this study was to provide an overview of clinical studies on calcitonin gene-related peptide (CGRP) measurements in body fluids of migraine patients and to discuss the validity of CGRP measurement as a clinical biomarker of migraine.

Recent findings
Several studies have reported increased CGRP levels in venous blood, saliva and tear fluid of migraine patients compared with healthy controls and in migraine patients during attacks compared with the interictal state, suggesting that CGRP may be a feasible biomarker of migraine. However, the findings of studies investigating CGRP levels in migraine patients are generally conflicting and measurements of CGRP levels are challenged by several methodological issues. Reported differences in CGRP levels between patients with chronic migraine relative to episodic migraine have also been inconsistent. There is also a well documented involvement of CGRP in several nonmigraine pain disorders, including cluster headache and common pain conditions such as osteoarthritis.

Summary
Current evidence does not justify the usage of CGRP levels as a biomarker for diagnosing migraine or for determining the severity of the disease in individual patients. However, CGRP measurements could prove useful in the future as clinically relevant biomarkers for predicting the response to therapy, including anti-CGRP migraine drugs.
From basic mechanisms to therapeutic perspectives in cluster headache
Authors: Moreno-Ajona David , Hoffmann Jan 
Published: June 2022

Purpose of review
The pathophysiological understanding of cluster headache has evolved significantly over the past years. Although it is now well known that the trigeminovascular system, the parasympathetic system and the hypothalamus play important roles in its pathomechanism, we increasingly understand the functional role several neurotransmitters and hormones play in the communication between these structures.

Recent findings
This work will give an overview of the current understanding of the role of calcitonin gene-related peptide, vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, melatonin and orexins in cluster headache. On the basis of recent evidence, this study will also review the relevance of the monoclonal calcitonin gene-related peptide antibody galcanezumab as well as the sleep-regulating hormone melatonin in the treatment of cluster headache.

Summary
Herein, we aim to review the basic mechanisms implicated in the pathophysiology of cluster headache and how the increased mechanistic understanding may lead to the discovery of novel therapeutic targets.
Solid fuel use status in the household and the risk of elevated blood pressure: findings from the 2017/18 Bangladesh Demographic and Health Survey
Authors: Paul Diba , Chowdhury Dia , Ali Hazrat , Islam Md. Syful , Ali Khan Md Mostaured , Khan Md. Nuruzzaman 
Published: June 2022

AbstractIntroductionPrevalence of hypertension is now increasing rapidly in Bangladesh, particularly among the socio-economically disadvantaged population. This could be linked to their higher use of solid fuel; however, related evidence is scarce in Bangladesh. We aimed to determine the associations of household solid fuel use and its exposure level with systolic blood pressure, diastolic blood pressure and hypertension.MethodsTotal of 7,320 women’s data extracted from the 2017/18 Bangladesh Demographic and Health Survey were analysed. We considered three outcome variables: (i) systolic blood pressure (continuous response), (ii) diastolic blood pressure (continuous response) and (iii) hypertension status (yes, no). Cooking fuel use (clean fuel vs solid fuel) and levels of exposure to household air pollution (HAP) through solid fuel use (unexposed, moderately exposed, highly exposed) were our primary exposure of interest. A multilevel mixed-effects Poisson regression model with robust variance was used to determine the association between exposure and outcome variable adjusting for confounders.ResultsAround 82% of the total respondents analysed used solid fuel for cooking. The overall age-standardised prevalence of hypertension was 28%. The likelihood of becoming hypertension was found 1.44 times (95% CI, 1.04-1.89) higher among respondents who used solid fuel as compared to the respondents who used clean fuel. The likelihood of hypertension was found to be increased with the increased exposure to HAP through the solid fuel used; 1.61 times (95% CI, 1.07-2.20) higher among the moderate exposure group and 1.80 times (95% CI, 1.27-2.32) higher among higher exposure group as compared to the women who used clean fuel. Similar associations were reported for systolic blood pressure and diastolic blood pressure.ConclusionSolid fuel use elevate systolic blood pressure, diastolic blood pressure and increases the likelihood of becoming hypertensive. Policies and programs are important to increase awareness about the adverse effects of solid fuel use on health, including hypertension. Focus should also be given to reducing solid fuel use and ensuring proper ventilation at the solid fuel use place.
A Deep Learning Enhanced Compartmental Model and its Application in Modeling Omicron Dynamics and Development in China
Authors: Deng Qi 
Published: June 2022

AbstractThe mainstream compartmental models require stochastic parameterization to estimate the transmission parameters between compartments, which depends upon detailed statistics on epidemiological characteristics that are economically and resource-wide expensive to collect. As an alternative, deep learning techniques are effective in estimating these stochastic parameters with greatly reduced dependency on data particularity. We apply deep learning to estimate transmission parameters of a customized compartmental model, then feed the estimated transmission parameters to the compartmental model to predict the development of the Omicron epidemics in China for 28 days. The average levels of predication accuracy of the model are 98% and 92% for number of infections and deaths, respectively.
Invariant categorical color regions across illuminant change coincide with focal colors
Authors: Morimoto Takuma , Yamauchi Yasuki , Uchikawa Keiji 
Published: June 2022

AbstractAre there regions in a color space where color categories are invariant across illuminant changes? If so, what characteristics make them more stable than other regions? To address these questions, we asked observers to give a color name to 424 colored surfaces, presented one at a time, under various chromatic illuminants. Results showed a high degree of categorical color constancy, especially under illuminants that occur in the natural environment. It was also shown that surfaces selected as a focal color (the best example of a color category) are more resistant to illuminant change than non-focal color samples. This might imply that categorically invariant regions might have become focal colors to facilitate object identification and communication with others under a variety of lighting environments. We additionally ran an asymmetric color matching experiment to quantify the shift of color appearance induced by illuminant changes using surfaces that were all named gray, thereby disentangling the appearance-based color constancy from the categorical color constancy (which are often confounded). Results suggested that the appearance of color samples largely shifted due to illuminant changes even though all samples were named gray; showing that the constancy of a color category is substantially more robust than the constancy of color appearance.
Workplace infection control measures and perceived organizational support during the COVID-19 pandemic in Japan: a prospective cohort study
Authors: Mori Takahiro , Nagata Tomohisa , Ando Hajime , Hino Ayako , Tateishi Seiichiro , Tsuji Mayumi , Matsugaki Ryutaro , Fujino Yoshihisa , Mori Koji ,   the CORoNaWork project
Published: June 2022

AbstractObjectiveWe investigated whether workplace infection control measures during the COVID-19 pandemic could increase perceived organizational support (POS).MethodsThis prospective cohort study was conducted in Japan from December 2020 to December 2021 using a questionnaire survey. There were 18,560 respondents at follow-up; we investigated 4,971 who rated low POS at baseline. The participants were asked a single question about POS and nine about workplace infection control measures. We determined the odds ratios (ORs) of high POS at follow-up using multilevel logistic regression analysis.ResultsThe groups of 5–6 (OR=1.29; 95% confidence interval [CI], 1.05–1.57; P=0.014) and 7–9 workplace infection control measures (OR=1.54; 95% CI, 1.28–1.85; P<0.001) had significantly higher ORs than the group with 0–2 measures.ConclusionsHealth support for employees through workplace infection control measures can increase POS.
Machine Learning Applications and Advancements in Alcohol Use Disorder: A Systematic Review
Authors: Hurtado Myrna , Siefkas Anna , Attwood Misty M , Iqbal Zohora , Hoffman Jana 
Published: June 2022

ABSTRACTBackgroundAlcohol use disorder (AUD) is a chronic mental disorder that leads to harmful, compulsive drinking patterns that can have serious consequences. Advancements are needed to overcome current barriers in diagnosis and treatment of AUD.ObjectivesThis comprehensive review analyzes research efforts that apply machine learning (ML) methods for AUD prediction, diagnosis, treatment and health outcomes.MethodsA systematic literature review was conducted. A search performed on 12/02/2020 for published articles indexed in Embase and PubMed Central with AUD and ML-related terms retrieved 1,628 articles. We identified those that used ML-based techniques to diagnose AUD or make predictions concerning AUD or AUD-related outcomes. Studies were excluded if they were animal research, did not diagnose or make predictions for AUD or AUD-related outcomes, were published in a non-English language, only used conventional statistical methods, or were not a research article.ResultsAfter full screening, 70 articles were included in our review. Algorithms developed for AUD predictions utilize a wide variety of different data sources including electronic health records, genetic information, neuroimaging, social media, and psychometric data. Sixty-six of the included studies displayed a high or moderate risk of bias, largely due to a lack of external validation in algorithm development and missing data.ConclusionsThere is strong evidence that ML-based methods have the potential for accurate predictions for AUD, due to the ability to model relationships between variables and reveal trends in data. The application of ML may help address current underdiagnosis of AUD and support those in recovery for AUD.