bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penyuluhan Tentang Pencegahan Praktik Prostitusi Online Di Madrasah Aliyah (MA) NU Tanjung Karang Kota Bandar Lampung
Authors: Salim Choirul , Aliyandi Aliyandi , Fitriyani Fitriyani , Selfiana Umniyatus 
Published: September 2022

ABSTRACT

The problem of prostitution is nothing new in Indonesian society, currently online-based prostitution is increasingly rampant. Several incidents during the period of June 2014, recorded the number of cases of prostitution in Bandar Lampung, as many as 84 cases of which happened to children / adolescents. And in 2016 this increased to 156 cases. From the above problems, the authors conducted service in the form of counseling on the prevention of online prostitution practice at Madrasah Aliyah (MA) NU Tanjung Karang, this location was chosen because this educational institution is in the middle of the city of Bandar Lampung. The purpose of this service is to provide knowledge on the importance of preventing online prostitution among adolescents. From the results of the counseling activities carried out, MA NU Tanjung Karang students and students are increasingly aware of the problem of online prostitution that is rife in the city of Bandar Lampung, understand the importance of sex knowledge, the impact of online protection, ways of prevention and know the regulations related to online prostitution and extension participants become aware of the importance of always upholding religious teachings, moral values, customs and complying with applicable legal norms.

Keywords: Counseling, Prevention, Online Prostitution
Pemberian Pemahaman Kepada Masyarakat Tentang Pelaksanaan Haji dan Umrah di Masa Pandemi Covid-19
Authors: Hakim Nasrul , Wahyudi Dedi , Khairunnisa Abidah , Jayanti Suci Hikma 
Published: September 2022

Abstrak
Pengabdian masyarakat yang dilakukan oleh tim dosen dan mahasiswa Institut Agama Islam Negeri Metro di Desa Sumber Rejo Kecamatan Bangkunat Kabupaten Pesisir Barat bertujuan untuk menggali potensi yang ada di desa tersebut. Tim berusaha bersosialisasi secara baik dengan masyarakat sekitar dan mengikuti setiap aturan yang ada di Desa Sumber Rejo. Selama beberapa hari tim pengabdian mengidentifikasi masalah di Pekon (desa) Sumber Rejo, Tim pengabdian menemukan berbagai macam permasalahan, salah satunya tentang pelaksanaan ibadah haji dan umrah. Sebelum melakukan perjalanan haji atau umrah ke Baitullah, calon jamaah diberikan bimbingan manasik terlebih dahulu oleh Kementrian Agama atau bisa melalui kelompok bimbingan ibadah haji dan umrah, gunanya mengikuti manasik ini adalah agar calon jamaah dapat mempelajari rukun dan syaratnya selama menjalani ibadah haji dan umrah. Dalam hal ini masyarakat mengalami (1) minimnya pengetahuan tentang manasik haji; (2) kurangnya pengetahuan seperti apa pelaksanaan manasik haji. Melalui bimbingan manasik haji dan umrah, calon jamaah dilatih praktek dan teori dalam perjalanan haji. Dalam kegiatan yang dilakukan oleh tim pengabdian

Kata kunci: Manasik, Pengabdian masyarakat, dan Pemberdayaan\
Combination of natural polyanions and polycations based on interfacial complexation for multi-functionalization of wound dressings
Authors: Li Shuyang , Wang Liya , Zhang Jue , Zhao Zijun , Yu Weifeng , Tan Zhi , Gao Po , Chen Xingtao 
Published: September 2022

Multi-functionalization of wound dressings with natural polymers is meaningful and remains a challenge. The combination of natural polyanions and polycations appears to be a promising strategy. Still, its performances based on current layer-by-layer self-assembly or homogeneous complexation are mutable and limited. Herein, Ca2+-incorporated carboxymethyl cellulose (Ca/Na-CMC) and hydroxypropyltrimethyl ammonium chloride chitosan (HACC) are adopted as the model polyanion and polycation, respectively, to develop multi-functionalized dressings based on interfacial complexation. The dressings exhibit a multilayer structure composed of a polyanion layer (Ca/Na-CMC) for hemostasis and promotion of cell proliferation, a formed polyelectrolyte complex (PEC) layer for structural stability, and a polycation layer (HACC) for antibiosis. Compared to the dressing based on homogeneous complexation, the multilayer dressings show stronger moisture penetrability (around 1,150 g/m2/24 h), higher hemostatic activity, and higher antibacterial rate (up to 100%) and promoted effect on cell proliferation. An in vivo evaluation using a rat full-thickness skin defect model reveals that the multilayer dressings can accelerate wound healing in 2 weeks. Overall, owing to interfacial complexation resulting in separate layers, the performances of polyanions and polycations after combination are more predictable, and their biological functions can be effectively preserved. These findings not only support the extensive application of multilayer dressings but also offer an alternative strategy for multi-functionalizing wound dressings with natural polyanions and polycations.
Simvastatin and fluvastatin attenuate trauma-induced cell death and catabolism in human cartilage
Authors: Riegger Jana , Maurer Svenja , Pulasani Sai , Brenner Rolf E. 
Published: September 2022

Joint injuries are known to induce pathomechanisms that might lead to posttraumatic osteoarthritis (PTOA). In this regard, statins with their pleiotropic effects could represent potential therapeutic agents in preventing the development of PTOA. Therefore, we investigated the effects of simvastatin and fluvastatin in a drop-tower-based human ex vivo cartilage trauma model. After 7 days, a mechanical impact (0.59 J) resulted in a decrease of the cell viability and increased expression of catabolic enzymes in cartilage explants. Simvastatin and fluvastatin treatment of impacted cartilage demonstrated cell protective effects in a concentration dependent manner. Moreover, statin therapy exhibited chondroprotective effects as demonstrated by attenuated expression of MMP-2 and MMP-13 as well as subsequent breakdown of collagen type II (after impact). Further analysis indicated antioxidative properties of the statins by upregulating the gene expression of SOD2 and suppression that of NOX2 and NOX4. Despite its protective effects, simvastatin impaired the biosynthesis of collagen type II, which was confirmed during chondrogenic redifferentiation of high passage chondrocytes. However, while long-term administration of statins for 4 weeks impaired chondrogenic redifferentiation, addition of simvastatin at low concentrations for 1 week exhibited a slightly promoting effect. In conclusion, our data imply that simvastatin and fluvastatin are suitable in terms of initial harm reduction after cartilage trauma.
Advances in electrochemical sensors based on nanomaterials for the detection of lipid hormone
Authors: Zhang Tingting , Du Xin , Zhang Zhenguo 
Published: September 2022

Lipid hormone is produced by highly differentiated endocrine cells and directly secretes into the blood circulation or tissue fluid to act as information transmission. It influences the physiological functions of the human body by controlling the metabolic processes of multiple tissue cells. Monitoring the levels of lipid hormone is of great importance for maintaining human health. The electrochemical sensor is considered as an ideal tool to detect lipid hormone owing to its advantages such as quick response, convenience and low economic costs. In recent 3 years, researchers have developed various electrochemical sensors for the detection of lipid hormone to improve their sensitivity or selectivity. The use of nanomaterials (such as carbon nanomaterials, precious metal and polymer) is a key research object and a breakthrough for improving the sensing performance of electrochemical sensors for detection of lipid hormone. This paper reviews and discusses the basic principle, nanomaterials, actuality and future development trend of electrochemical sensors for the detection of lipid hormone in the past 3 years.
The application of biomaterials in osteogenesis: A bibliometric and visualized analysis
Authors: Wang Jie , Chi Yuan , Yang Baohui , Zhang Qiongchi , Wang Dong , He Xijing , Li Haopeng 
Published: September 2022

Osteogenesis serves an important role in bone tissue repairing. Novel biomaterials are widely prevalent as materials for orthopedic implants due to their biocompatibility and osteogenetic ability. The purpose of this study was to comprehensively analyze hotspots and future trend of biomaterials research in osteogenesis based on bibliometric and visualized analysis. A total of 1,523 papers about biomaterials research in osteogenesis between 2000 and 2021 were included in this study. During the above 20 years, China’s leading position in the global biomaterials research in osteogenesis was obvious, and it was also the country that most frequently participates in international cooperation. Chinese Academy of Sciences was the most productive institution and the leader of research cooperation. Acta Biomaterialia and Biomaterials have published the largest number of articles in the field of biomaterials research in osteogenesis. Meanwhile, Acta Biomaterialia and Biomaterials were also the two journals with the highest total citation frequency. Wu CT, Chang J, Kaplan DL, and Xiao Y all made important contributions in the field of biomaterials research in osteogenesis. At present, there are five research hotspots in the field of biomaterials research in osteogenesis: 1) the immunomodulatory role of biomaterial-related inflammatory; 2) mechanisms of osteogenesis in biomaterials; 3) 3D printing and clinical application of biomaterials; 4) bone tissue engineering for biomaterial osteogenesis; and 5) regenerative medicine for biomaterial osteogenesis. The results of this study showed that mechanisms of osteogenesis in biomaterials, bone tissue engineering for biomaterial osteogenesis, and regenerative medicine for biomaterial osteogenesis will remain research hotspots in the future. International cooperation was also expected to expand and deepen the field of biomaterials research in osteogenesis.
A novel room-temperature formaldehyde gas sensor based on walnut-like WO3 modification on Ni–graphene composites
Authors: Mehmood Shahid , Khan Faheem Ullah , Shah Muhmmad Naeem , Ma Junxian , Yang Yatao , Li Guijun , Xu Wei , Zhao Xiaojin , He Wei , Pan Xiaofang 
Published: September 2022

Ternary composite with great modulation of electron transfers has attracted a lot of attention from the field of high-performance room-temperature (RT) gas sensing. Herein, walnut-like WO3-Ni–graphene ternary composites were successfully synthesized by the hydrothermal method for formaldehyde (HCHO) sensing at RT. The structural and morphological analyses were carried out by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS). SEM and TEM studies confirmed that walnut-like WO3 nanostructures with an average size of 53 ± 23 nm were functionalized. The Raman and XPS results revealed that, due to the deformation of the O-W-O lattice, surface oxygen vacancies Ov and surface-adsorbed oxygen species Oc were present. The gas-sensing measurement shows that the response of the WO3-Ni-Gr composite (86.8%) was higher than that of the Ni-Gr composite (22.7%) for 500 ppm HCHO at RT. Gas-sensing enhancement can be attributed to a p-n heterojunction formation between WO3 and Ni-Gr, Oc, spill-over effect of Ni decoration, and a special walnut-like structure. Moreover, long term stability (%R = 61.41 ± 1.66) for 30 days and high selectivity in the presence of other gases against HCHO suggested that the proposed sensor could be an ideal candidate for future commercial HCHO-sensing in a real environment.
Temporal trends in pulse pressure and mean arterial pressure in Chinese children and adolescents over two decades (1991–2015)
Authors: Zhang Xinyue , Zhu Yunying , Li Shuting , Ye Xinxin , Hou Leying , You Yating , Wang Chenyu , Wu Yuhang , Zhang Junmeng , Wang Yinlin , Song Peige , Mao Xi 
Published: September 2022

BackgroundPulse pressure (PP) and mean arterial pressure (MAP) are well-established markers of cardiovascular risk. In this study, we aimed to assess the temporal trend and associated factors of PP and MAP in Chinese children and adolescents.MethodsFrom the China Health and Nutrition Survey 1991–2015, a total of 11,123 children and adolescents aged 7–17 years were included. Stratified analyses and generalized estimating equation (GEE) were conducted to compare the trends of PP and MAP by age and sex over two decades, along with the calculation of average relative increase (ARI). Moreover, multivariable linear regression was used to estimate the associated factors of PP and MAP.ResultsDuring 1991–2015, upward trends were observed in both PP and MAP levels, with ARI of 0.30 and 0.34%, respectively. PP was higher in boys [PP1991 33.9 mmHg (95%CI, 33.40–34.33) to PP2015 35.4 mmHg (34.74–36.15)] than in girls [PP1991 33.3 mmHg (32.83–33.72) to PP2015 34.3 mmHg (33.59–34.99)]. PP was also higher in participants aged 13–17 years [PP1991 36.1 mmHg (35.63–36.62) to PP2015 38.3 mmHg (37.35–39.21)] than in those aged 7–12 years [PP1991 31.5 mmHg (31.09–31.88) to PP2015 33.7 mmHg (33.16–34.30)]. Similar results were found in MAP. Participants with high economic status, general obesity and central obesity, were more likely to have wider PP (βhigheconomicstatus = 0.60, 95% CI, 0.19–1.02; βgeneralobesity = 1.38, 0.87–1.89; βcentralobesity = 1.34, 0.70–1.97; all P-values &lt; 0.001) and higher MAP (βhigheconomicstatus = 0.82, 0.38–1.26; βgeneralobesity = 2.88, 2.33–3.42; βcentralobesity = 3.14, 2.47–3.80; all P-values &lt; 0.001). Body mass index (BMI) and waist circumference (WC) were positively correlated with PP (βBMI = 0.18, 0.13–0.24; βWC = 0.10, 0.08–0.12; both P-values &lt; 0.001) and MAP (βBMI = 0.43, 0.37–0.49; βWC = 0.20, 0.18–0.22; both P-values &lt; 0.001). In addition, rural setting and glucose level were positively associated with PP (both P &lt; 0.05), while north region residency, uric acid, and total cholesterol were found to be positively associated with MAP (all P &lt; 0.05).ConclusionPP and MAP levels have been increasing dramatically in Chinese children and adolescents over the last two decades. Age, sex, economic status, geographic factors, anthropometric and cardiometabolic factor were positively associated with PP and MAP in pediatric population.
Comparative analysis of right ventricular metabolic reprogramming in pre-clinical rat models of severe pulmonary hypertension-induced right ventricular failure
Authors: Banerjee Somanshu , Hong Jason , Umar Soban 
Published: September 2022

BackgroundPulmonary hypertension (PH) leads to right ventricular (RV) hypertrophy and failure (RVF). The precise mechanisms of the metabolic basis of maladaptive PH-induced RVF (PH-RVF) are yet to be fully elucidated. Here we performed a comparative analysis of RV-metabolic reprogramming in MCT and Su/Hx rat models of severe PH-RVF using targeted metabolomics and multi-omics.MethodsMale Sprague Dawley rats (250–300 gm; n = 15) were used. Rats received subcutaneous monocrotaline (60 mg/kg; MCT; n = 5) and followed for ~30-days or Sugen (20 mg/kg; Su/Hx; n = 5) followed by hypoxia (10% O2; 3-weeks) and normoxia (2-weeks). Controls received saline (Control; n = 5). Serial echocardiography was performed to assess cardiopulmonary hemodynamics. Terminal RV-catheterization was performed to assess PH. Targeted metabolomics was performed on RV tissue using UPLC-MS. RV multi-omics analysis was performed integrating metabolomic and transcriptomic datasets using Joint Pathway Analysis (JPA).ResultsMCT and Su/Hx rats developed severe PH, RV-hypertrophy and decompensated RVF. Targeted metabolomics of RV of MCT and Su/Hx rats detected 126 and 125 metabolites, respectively. There were 28 and 24 metabolites significantly altered in RV of MCT and Su/Hx rats, respectively, including 11 common metabolites. Common significantly upregulated metabolites included aspartate and GSH, whereas downregulated metabolites included phosphate, α-ketoglutarate, inositol, glutamine, 5-Oxoproline, hexose phosphate, creatine, pantothenic acid and acetylcarnitine. JPA highlighted common genes and metabolites from key pathways such as glycolysis, fatty acid metabolism, oxidative phosphorylation, TCA cycle, etc.ConclusionsComparative analysis of metabolic reprogramming of RV from MCT and Su/Hx rats reveals common and distinct metabolic signatures which may serve as RV-specific novel therapeutic targets for PH-RVF.
Safety and efficacy of zero-fluoroscopy catheter ablation for paroxysmal supraventricular tachycardia in Chinese children
Authors: Cui Xiaoran , Li Ruibin , Zhou Wenli , Zhang Xiaohui , Wang Xiaoning , Zhang Jidong 
Published: September 2022

ObjectivesTo compare the safety and efficacy of completely zero-fluoroscopy radiofrequency ablation (RFA) with that of conventional RFA guided by three-dimensional mapping in Chinese children with paroxysmal supraventricular tachycardia (PSVT).MethodsThe study had a single-center observational design and included 46 children aged 6–14 years who underwent RFA for PSVT at the Second Hospital of Hebei Medical University between March 2019 and September 2021. The children were divided according to whether they underwent zero-fluoroscopy RFA (zero-fluoroscopy group, n = 26) or routine RFA under X-ray guidance (conventional group, n = 20). Three-dimensional mapping was used in both groups. Baseline characteristics, total procedure time, RFA time, volume and duration of X-ray exposure, target mapping time, the immediate RFA success rate, incidence of complications, and recurrence rate were compared between the two groups.ResultsThe children had a median age of 12 years (interquartile range 10, 13), 47.8% (22/46) were boys, and 52.2% (24/46) were girls. The mean body weight was 48.75 ± 15.26 kg. There was no significant between-group difference in the baseline data (P &gt; 0.05). All children were followed up as outpatients at 1, 3, and 6 months postoperatively. The target mapping time was significantly longer in the zero-fluoroscopy group than in the conventional group (12.96 ± 2.24 min vs. 6.65 ± 2.56 min, P &lt; 0.05); however, there was no significant between-group difference in the immediate success rate (100% vs. 100%), success rate at 6 months postoperatively (92.30% vs. 95.00%), complication rate (0% vs. 0.05%), recurrence rate (7.70% vs. 5.00%), RFA time (212.50 s vs. 214.00 s), or total procedure time (78.50 min vs. 74.00 min) (P &gt; 0.05).ConclusionZero-fluoroscopy catheter ablation can completely avoid fluoroscopy exposure in children without affecting the safety and efficacy of RFA.
Optimizing estradiol level for gonadotrophin-releasing hormone antagonist initiation among patients with simple tubal factor infertility
Authors: Wang Yizhuo , Xu Xiuhua , Yang Ai-min , Zhang Jie , Luo Zhuo-ye , Han Yan , Cui Na , Li Qian , Shi Baojun , Zhao Zhi-ming , Hao Gui-min 
Published: September 2022

ObjectiveThe aim of this study is to investigate the optimal estradiol (E2) level on the day of gonadotropin-releasing hormone antagonist (GnRH-ant) initiation to maximize the clinical pregnancy rate (CPR) after fresh embryo transfer among patients with simple tubal factor infertility.MethodsA retrospective cohort study was conducted in the Reproductive Medicine Center, the Second Hospital of Hebei Medical University. A total of 1,493 IVF-ET cycles of patients diagnosed with single tubal factor infertility from August 2016 to August 2021 were included and equally allocated into five distinct groups according to the quintile serum E2 levels on the day of GnRH-ant initiation. The five groups had similar baseline data except for antral follicle count.Result(s)The serum E 2 level on GnRH-ant initiation day was determined as an independent predictor of clinical pregnancy after adjusting for confounding factors such as age, infertility duration, body mass index, cycle number, antral follicle count, and the number of transferred embryos. Through smooth curve fitting, we found that, with the increase of serum E2 levels on the day of GnRH-ant initiation, CPR showed a trend of slight increase and then slight decrease. The maximal CPR was achieved when the serum E2 level on GnRH-ant initiation day was 498 pg/ml. When E2 was less than 498 pg/ml, the odds ratio (OR) of clinical pregnancy was 1.05 (95% CI: 1.00, 1.11, P = 0.0583). When E2 was greater than 498 pg/ml, the OR of clinical pregnancy was 0.97 (95% CI: 0.95, 0.98, P = 0.0003). Furthermore, CPR remained high when E2 was 436.8–658.6 pg/ml but declined significantly by more than 40% when E2 was ≥ 894.4 pg/ml (P &lt; 0.05).Conclusion(s)The serum E2 level should be considered as an adjuvant parameter for GnRH-ant initiation. The best E2 value was 498 pg/ml, and GnRH-ant administration could be recommended to initiate when serum E2 was 436.8–658.6 pg/ml. If GnRH-ant was initiated when serum E2 was above 894.4 pg/ml, then the CPR after fresh embryo transfer may decline dramatically, and thus, cancellation of fresh embryo transfer and earlier initiation of GnRH-ant in future cycles should be considered.
Review of online measurement techniques for chemical composition of atmospheric clusters and sub-20 nm particles
Authors: Zhang Kewei , Xu Zhengning , Gao Jian , Xu Zhuanghao , Wang Zhibin 
Published: September 2022

The chemical composition of aerosol particles is crucial to understanding their formation and evolution in the atmosphere. However, very limited information is available for the chemical composition of ultrafine particles, particularly for nanoclusters and newly formed particles, due to the lack of valid analytical methods. This work reviews the online measurement techniques for characterizing the chemical composition of atmospheric clusters and sub-20 nm particles. The commonly used instrumentations are divided into two categories: direct techniques based on mass spectrometry and indirect measurement techniques mainly relying on the physical properties (e.g., hygroscopicity and volatility). The advantages of these techniques are compared and their limitations in the lab and field application are summarized. The combination of direct and indirect techniques is discussed, and this may provide more comprehensive understanding of chemical information of atmospheric clusters and particles. We propose that the newly developing instrumentations are needed to improve the collection efficiency for direct techniques, or the chemical resolution for indirect techniques. Future development should focus on obtaining simultaneous measurements of particle physical and chemical properties, which can be helpful in improving the accuracy of modeling and the understanding of particle formation and evolution.