bluuebunny/crossref_metadata_2025_split huggingface dataset:
Total Family Risk in Displaced Families in a Municipality of Colombia
Authors: Ospina Martha Cecilia , Arenas Dolly Villegas , Coral Imer Andrés Díaz , Salazar Angie Loriteh Narváez , Naranjo José Over Garzón 
Published: May 2022

Abstract
In Colombia, the civil war has generated family displacement, leading to experiences of social and cultural uprooting. The total Family Risk was determined in a group of 30 displaced Afro-descendant families, for which the RFT 5–33 instrument was used, with prior informed consent. The results show a predominance of nuclear families (40%), predominance of threatened families (56%), especially in the dimensions of housing and neighborhood, socioeconomic situation, health practices and services, and psycho-affective conditions. The correlation showed that Total Family Risk has a strong correlation with health practices and services (0.888) and with the management of minors (0.86). The findings provide elements to implement family care actions in health promotion and prevention.
Unintended effects of transgenic rice on grain yield and quality traits determined by quantitative proteomics
Authors: Sun Yue , Chen Huizhen , Chen Zhongkai , Wang Chunlei , Qin Lu , Lin Xiaoli , Cai Yicong , Zhou Dahu , Ouyang Linjuan , Zhu Changlan , Peng Xiaosong , He Haohua 
Published: May 2022

Abstract
Omics techniques provide effective detection tools for assessing the potential impact of plant composition at the DNA, RNA, and protein levels. Among these, protein is the executor of gene function and the embodiment of biological traits, so that organisms show various genetic characteristics. Proteomics can be used to assess whether genetic engineering will lead to changes in plant traits beyond those introduced by conventional plant breeding. Here, we compare the extent of the proteome occurring in the leaves of three transgenic rice restore lines expressing CRY1C and CRY2A genes developed by genetic engineering and their corresponding recurrent parents developed by conventional breeding. CRY1C and CRY2A genes were inserted into chromosomes 11 and 12, respectively, which significantly improved the resistance of restore lines to Chilo suppressalis. Although differentially expressed proteins could be distinguished between transgenic rice and its recurrent parents, these differences were not sufficient to cause unintended effects on grain yield and quality traits of transgenic rice. In contrast, differences in phenotypic traits are more because of differences in genetic background. Functional cluster analysis showed that the differentially expressed proteins caused by the insertion of exogenous genes did not involve harmful metabolic pathways. The study successfully used 4D label-free quantitative proteomics technology to assess the unexpected changes in new rice varieties, and the results showed that transgenic rice did not cause unintended effects.
Evaluation of satellite-based air temperature estimates at eight diverse sites in Africa
Authors: Parsons Danny , Stern David , Ndanguza Denis , Sylla Mouhamadou Bamba 
Published: May 2022

Abstract
High resolution satellite and reanalysis-based air temperature estimates have huge potential to complement the sparse networks of air temperature measurements from ground stations in Africa, and support vital studies in health, agriculture, diseases, and climate change. The recently released Climate Hazards Center Infrared Temperature with Stations (CHIRTS-daily) dataset provides daily minimum and maximum air temperature estimates on a near-global scale from 1983 to 2016. This study assesses the performance of CHIRTS-daily in comparison with measurements from eight ground stations in diverse locations across Africa from 1983 to 2016 and benchmarked against the ERA5 and ERA5-Land reanalysis in order to understand its potential to provide localised temperature information. CHIRTS-daily maximum temperature exhibits good performance across the sites, measures and time scales. Compared to ERA5 and ERA5-Land, CHIRTS-daily has higher correlation and lower bias of daily, annual mean maximum and annual extreme maximum temperature, often within 1.0° on average. It also exhibits significant trends in annual mean maximum temperature, comparable to those from the station data. CHIRTS-daily minimum temperatures generally has higher correlation, but larger bias than ERA5 and ERA5-Land, at more than 2° at four sites. However, the results indicate that CHIRTS-daily minimum temperature biases may be largely systematic, and therefore could potentially be corrected for. Overall, CHIRTS-daily is highly promising as it outperforms ERA5 and ERA5-Land in many areas, and exhibits good results across a small, but diverse set of sites in Africa. Further studies to understand performance in specific geographic areas and terrains could help support these findings.
The pancreas-to-muscle signal intensity ratio on T 1 -weighted MRI as predictive biomarker for postoperative pancreatic fistula after distal pancreatectomy: A single-center retrospective study
Authors: Fukada Masahiro , Murase Katsutoshi , Higashi Toshiya , Fujibayashi Seito , Kuno Masashi , Yasufuku Itaru , Sato Yuta , Kiyama Shigeru , Tanaka Yoshihiro , Okumura Naoki , Matsuhashi Nobuhisa , Takahashi Takao 
Published: May 2022

Abstract
Background: Postoperative pancreatic fistula (POPF) is the most serious complication in pancreatic surgery. When POPF occurs and becomes severe, it causes secondary complications and leads to a longer treatment period. We previously reported a correlation between pancreatic fibrosis and magnetic resonance imaging (MRI) findings, and MRI may have potential to predict for POPF. This study aimed to assess the diagnostic ability of the pancreas-to-muscle signal intensity ratio on T1-weighted MRI (SIR on T1-w MRI) for POPF after distal pancreatectomy (DP). Methods: This retrospective, single-institution study comprised 117 patients who underwent DP for pancreatic disease between 2010 and 2021 at the Gifu University Hospital. We statistically analyzed pre-, intra-, and post-operative factors to assess the correlation with POPF. Results: According to the definition and grading of the International Study Group of Pancreatic Fistula (ISGPF), 29 (24.8%) of 117 patients had POPF grades B and C. In the univariate analysis, POPF was significantly associated with the pancreas-to-muscle SIR on T1-w MRI, the drainage fluid amylase concentration (D-Amy) levels on postoperative day (POD)1 and 3, white blood cell count on POD1 and 3, C-reactive protein level on POD3, and heart rate on POD3. In multivariate analysis, only the pancreas-to-muscle SIR on T1-w MRI (>1.37; odds ratio [OR] 23.25; 95% confidence interval [CI] 3.93 – 454.03; p < 0.01) and D-Amy level on POD3 (>737 U/L; OR 3.91; 95% CI 1.02 – 16.36; p = 0.046) were identified as independent predictive factors. In addition, the pancreas-to-muscle SIR on T1-w MRI showed significant positive correlations with D-Amy levels both on POD1 and 3(p < 0.01), and was significantly higher in non-pancreatic ductal adenocarcinoma cases (p < 0.01) and soft pancreas cases (p=0.04).Conclusions: The pancreas-to-muscle SIR on T1-w MRI was able to diagnose the development of POPF after DP as well as postoperative D-Amy levels. Furthermore, the pancreas-to-muscle SIR on T1-w MRI also showed significantly correlated with pancreatic disease and pancreatic texture. The pancreas-to-muscle SIR on T1-w MRI may be a potential objective biomarker reflecting pancreatic status.
A Multicenter, Dose-Escalation, Open-Label, Phase IIa Clinical Trial to Evaluate the Safety and Efficacy of TTAC-0001 (olinvacimab), a Fully Human Monoclonal Antibody in Patients with Recurrent Glioblastoma
Authors: Balasubramanian Adithya , Iatropoulos George , Bowyer Samantha , Gan Hui Kong , Long Anne P , Bynevelt Michael , Jackson Graeme , Lee Seon Young , Lee Weon Sup , Yoo Jinsan , Nowak Anna , Cher Lawrence 
Published: May 2022

Abstract
Introduction The VEGF pathway remains an important target in GBM given its vascularity and autocrine VEGF signalling. Olinvacimab is a fully humanised VEGFR2 monoclonal antibody that binds and inhibits the receptor. This report assesses the safety, dosing schedules and efficacy of olinvacimab in recurrent GBM (rGBM). Methods Adult patients with a measurable lesion, histopathological diagnosis of primary GBM with tumour progression after chemoradiotherapy were included. No prior biologic treatment was allowed. Three dose levels of intravenous olinvacimab were assessed: 8 mg/kg (dose level 1) and 12mg/kg (dose level 2) weekly for 3 out of 4 weeks, and 12 mg/kg weekly (dose level 3). Efficacy was assessed by MRI using RANO criteria. Dynamic Contrast-Enhanced MRIs (DCE-MRIs) were analysed for changes in perfusion parameters during treatment. Results Twelve patients were enrolled in this study: three each in dose levels 1 and 2, and six in dose level 3. The main toxicity was development of grade 1 (67%) and 2 (8%) cutaneous haemangiomas. Common toxicities noted with other VEGF directed therapies- including hypertension, impaired wound healing, and proteinuria- were not seen. The 6-month progression free survival rate was 17%, disease control rate 25%, and the longest response 15 months. No significant difference in perfusion parameters was found between baseline and 1st follow-up DCE-MRI comparing those with stable and progressive disease. ConclusionOlinvacimab was well tolerated across three dose levels and had a distinct toxicity profile. Disease control was seen in 25% of patients and warrants further follow up in further clinical trials.
Unidirectional Single-File Transport of Full-Length Proteins Through a Nanopore
Authors: Yu Luning , Kang Xinqi , Li Fanjun , Mehrafrooz Behzad , Makhamreh Amr , Fallahi Ali , Aksimentiev Aleksei , Chen Min , Wanunu Meni 
Published: May 2022

Abstract
Nanopore sequencing is one of only a few methods that can potentially determine the amino acid sequence of individual protein molecules as these are passed through a pore sensor. However, mechanisms for unfolding and translocation of proteins are still unavailable to date. Here we describe a general approach for realizing unidirectional transport of full-length proteins through nanopores. We combine a chemically resistant biological nanopore platform with a high concentration guanidinium chloride buffer to achieve unidirectional, single-file protein transport that is propelled by a giant electro-osmotic effect, as revealed by molecular dynamics simulations and confirmed experimentally. Remarkably, we observed that protein velocities are uniform regardless of the protein sequence, which allows the identification and discrimination among proteins based on their electrical signatures, as well as to distinguish protein signatures by their threading orientation (N-to-C vs. C-to-N terminus). With average transport velocities of 10 µs per amino acid, our method can enable direct, enzyme-free protein fingerprinting and protein sequencing when combined with a high-resolution pore and high-speed nanopore readout.
An Enhanced Donkey and Smuggler Optimization Algorithm for Choosing the Precise Job Applicant
Authors: Hasan Nazir M. , Rashid Tarik A. , Alsadoon Abeer , Qosaeri Ahmed S. , Abualigah Laith 
Published: May 2022

Abstract
Throughout the last few decades, Nature-Inspired Algorithms (NIA) have become very popular in solving real-world problems by getting inspiration from nature and animals' and insects' social behavior. This work suggests the Modified Donkey and Smuggler Optimization (MDSO) algorithm for solving the selection problem to choose the suitable job applicants for a specific position. The original Donkey and Smuggler Optimization algorithm (DSO) has two modes: smuggler and donkey mode (non-adaptive and adaptive, respectively). In the smuggler mode, the algorithm tries to find the best solutions, which is the path to send the donkey to the destination; once the best path is found, the smuggler will send the donkey through the selected path. The donkey's actions will start when the smuggler mode's best solution is no longer the best one. Certain modifications have been made in the smuggler mode, including replacing the original fitness with a new fitness equation since that method can work more accurately. The Human Resource (HR) department in Korek-telecom has been used as a resource to achieve real-world data to test the original and Modified DSO. By using MDSO, not only will organizations be able to choose suitable job applicants more accurately but will manage to do so at a faster pace as well.
Developing a conceptual model for understanding nutritional problems and health-related outcomes among Chinese patients with type 2 diabetes: implications for digital health interventions
Authors: Yun WANG , Xiangping YUAN , Xianju GU , Changxiu MENG , Yanling ZHENG 
Published: May 2022

Abstract
Background: It is generally agreed that a healthy diet could promote the management of diabetes, with emerging research indicating the potential delay and prevention of T2DM and its complications. This study used a qualitative method to obtain a first-hand and in-depth understanding of nutritional problems and concerns among patients with type 2 diabetes and explored the negative impacts of insufficient nutrition management on quality of life.Methods: Twenty-one adult patients with type 2 diabetes participated in a semi structured interview regarding nutritional problems and negative impacts on quality of life. Recordings were transcribed verbatim, and content analysis was used to identify themes.Results: Four themes emerged from the analysis to represent nutritional problems and negative impacts on quality of life: nutrition literacy, sociocultural aspects of nutrition, behaviours and nutrition management, and negative health-related outcomes .Conclusions: Considering the nutrition issues and the negative impacts among Chinese patients with type 2 diabetes, digital health intervention was an effective way to improve their health-related outcomes. Personal, social, cultural and religious factors should all be taken into consideration when promoting nutrition knowledge and behaviours.
A multi-criteria approach for improving streamflow prediction in a rapidly urbanizing data scarce catchment
Authors: Panchanathan Anandharuban , Haghighi Ali Torabi , Oussalah Mourad 
Published: May 2022

Abstract
This study advocates a multi-criteria approach to improve the streamflow predictions in a data-scarce catchment of Chennai metropolitan city of India using the Soil Water and Assessment Tool (SWAT). The remotely sensed evapotranspiration (ET) data, groundwater recharge estimation and parameter regionalization were used to improve model prediction. Dynamic change of Land Use and Land Cover (LULC) was accounted for along with multi-parameter calibration for reducing the uncertainty in model parameters. The results revealed an improved streamflow prediction accuracy by 10%, especially in the prediction of medium and high flows with the Nash-Sutcliffe efficiency of 0.60. The enhanced parameters were regionalized to ungauged sub-basins and validated using a measured flow event downstream of regionalization with 15% prediction uncertainty. This semi-arid catchment is dominated by ET (58%) and runoff (27%) in the region's hydrology. The finding of this study can be applied to improve the hydrological modeling and predictions in data-scarce regions.
Structural and Functional Annotation and Molecular Docking Analysis of a Hypothetical Protein from Neisseria gonorrhoeae, An In-silico Approach
Authors: Mazumder Lincon , Hasan Md. Rakibul , Fatema Kanij , Islam Md Zahirul 
Published: May 2022

Abstract
Background
The threat of sexually transmitted diseases (STDs) is a significant public health concern. Blood, sperm, vaginal, and other bodily fluids can transport bacteria, viruses, and parasites that cause sexually transmitted diseases from one person to another. Neisseria gonorrhoeae is one of the microorganisms responsible for sexually transmitted diseases (STDs). It is an aerobic gram-negative bacterium with a large genome that contains numerous proteins, some of which are considered hypothetical.
Methods
In this study, the hypothetical protein of Neisseria gonorrhoeae F0T10 13280 was chosen for analysis and used an in-silico approach to explore various properties such as physicochemical characteristics, subcellular localization, secondary structure, 3D structures, and functional annotation. Finally, a molecular docking analysis was performed to design an epitope-based vaccine against this protein.
Results
This study has identified the potential role of the HP in plasmid transfer, cell cycle control, cell division, and chromosome partitioning. Acidic nature, thermal stability, cytoplasmic localization of the protein and some of its other physicochemical properties has also been identified through this study. Molecular docking analysis has demonstrated that one of the T cell epitopes of the protein has a significant binding affinity with the human leucocyte antigen HLA-B*3501.
Conclusions
The in-silico characterization of this protein will help us understand its molecular mechanism of action and get an insight into novel therapeutic identification processes. This research will, therefore, enhance our knowledge to find new medications to tackle this potential threat to humankind.
Correlation analysis of the elastic-ideal plastic material behavior of short fiber-reinforced composites
Authors: Rauter Natalie 
Published: May 2022

Abstract

For the numerical simulation of short fiber-reinforced composites and the correct analysis of the deformation information about the plastic behavior and its spatial distribution is essential. When using purely deterministic modeling approaches information of the probabilistic microstructure is not included in the simulation process. One possible approach for the integration of stochastic information is the use of random fields, which requires information about the correlation structure of all material input parameters. In this study the correlation structure for finite strain elasto-plastic material behavior of short fiber-reinforced composites is analyzed. This approach combines the use of already established procedures for linear-elastic material behavior with a homogenization method for plasticity. The obtained results reveal a complex correlation structure, which is approximated with triangle and exponential correlation functions influenced by the window size. Due to the dependence of the hyperelastic and plastic material parameters on the fiber volume fraction, the strain-energy density function coefficients are cross-correlated with the yield strength of the composite. Subsequently, in a subsequent part of this study numerical simulations of tensile tests are conducted that cover the elastic and plastic domain and include spatially distributed material properties.
Low-level laser therapy (photo-biomodulation therapy) for breast cancer-related lymphedema: A systematic review
Authors: Mahmood Dania , Ahmad Ashfaq , Arslan Asad , Sharif Faiza 
Published: May 2022

Abstract
Background: Breast cancer-related lymphedema (BCRL) is a frequent issue that arises after mastectomy surgery in women and compromises physical and mental function. Previously published studies have shown positive effects with the use of Photo-biomodulation is another term for low-level laser treatment (LLLT) (PBM). This research investigated the efficacy of LLLT (PBM) in the treatment of Metastatic breast cancer related lymphedema.Methods: PubMed, PEDro, Medline, and the Cochrane Library were searched for LLLT clinical trials published before October 2021. The methodological quality of randomized trials and the effectiveness of Laser therapy for BCRL were evaluated. The primary objectives were arm circumference or arm volume, whereas the secondary goals were shoulder mobility and pain severity.Results: Eight clinical trials were analysed in total. Typically, the included RCTs had good research quality. At four weeks, there was a considerable reduction in arm circumference/volume, and this continued with long-term follow-up. However, no statistically significant change in shoulder mobility or pain severity was seen between the laser and placebo groups at 0-, 1-, 2-, and 3-month short-term follow-up.Conclusions: The findings of this comprehensive study demonstrated that LLLT (PBM) was successful in diminishing arm circumference and volume than improving shoulder mobility and pain. Data indicate that laser therapy (PBM) may be a beneficial treatment option for females with PML. Because of the scarcity of evidence, there is a strong need for well-conducted trials in this field.Trial registration: Details of the protocol for this systematic review were registered on PROSPERO and can be accessed at www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42022315076.
Epigraphene: the first viable platform for seamless zero-mode graphene nanoelectronics
Authors: Prudkovskiy Vladimir , Hu Yiran , Hu Yue , Zhang Kaimin , Ji Peixuan , Nunn Grant , Zhao Jian , Shi Chengqian , Tejeda Antonio , Wander David , de Cecco Alessandro , Winkelmann Clemens , Jiang Yuxuan , Zhao Tianhao , Wakabayashi Katsunori , Jiang Zhigang , Ma Lei , Berger Claire , de Heer Walt 
Published: May 2022

Abstract
A graphene nanoelectronics platform -envisioned as scalable seamlessly integrated graphene nanoscale devices -has failed to materialize due to pervasive edge disorder caused by lithographic processes that diminish the mobility and destroy the edge state in exfoliated graphene nanoribbons. Here we demonstrate, for the first time, graphene edge state transport in conventionally patterned graphene ribbon networks produced on graphene that is epitaxially grown on non-polar faces of electronics grade silicon carbide wafers (epigraphene). The epigraphene edge state is extremely robust to lithography processing, as the graphene edge atoms bind to the SiC substrate. The protected edge state has a mean free path that is greater than 50 microns, 5000 times greater than the bulk states. It involves a non-degenerate, spin polarized, zero-energy electronic band that does not produce a Hall voltage. In seamless integrated structures, the edge state forms a zero-energy one-dimensional ballistic network with essentially dissipationless nodes at ribbon-ribbon junctions. Its novel properties point to an unconventional charge carrier that is half-electron and half-hole. Seamless integrated graphene edge state device structures that are phase coherent at low temperatures offer a variety of switching possibilities. This makes epigraphene the only technologically viable graphene nanoelectronics platform that has the potential to succeed silicon nanoelectronics.