bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of subcutaneous allergen immunotherapy in atopic dogs: A retrospective study of 664 cases
Authors: Fennis Evelien E. M. , van Damme Catharina M. M. , Schlotter Yvette M. , Sinke Jacqueline D. , Leistra Mieke H. G. , Bartels Richard T. , Broere Femke 
Published: May 2022

AbstractBackgroundCanine atopic dermatitis (cAD) is an allergic skin disease affecting approximately 10% of dogs. allergen‐specific immunotherapy (ASIT) is currently the only treatment option able to induce tolerance to the causative allergens.ObjectiveTo retrospectively establish the efficacy of ASIT in atopic dogs.AnimalsClient‐owned (n = 664) dogs with cAD presented between 2008 and 2018 to two dermatology referral clinics.Materials and MethodsClinical records of atopic dogs were reviewed to obtain information including the results of the intradermal skin test and/or allergen‐specific immunoglobulin (Ig)E serological results, the allergens included in the ASIT, concurrent symptomatic medications, and ASIT efficacy after at least 9 months.ResultsExcellent (ASIT alone controlled clinical signs), good (≥50% reduction of clinical signs) and poor (<50% improvement) responses were seen in 31.5%, 28.5% and 40.1% of the dogs, respectively. No significant differences in efficacy were associated with breed, sex, age at initiation of ASIT, type of allergens in ASIT, and between clinics. Dogs re‐examined regularly responded significantly better to ASIT than dogs that did not (>50% improvement in 69.3% and 55.4% of the dogs, respectively). Dogs treated with ASIT and concomitant systemic glucocorticoids showed a significantly poorer response (success rate of >50% improvement of 38.5%).Conclusions and clinical importanceIn 59.9% of atopic dogs, subcutaneous ASIT can improve clinical signs by ≥50%. The beneficial effect of ASIT is higher if dogs are re‐examined regularly and if systemic long‐term corticosteroids are avoided, at least during the first 9 months of ASIT.
Clinical and CT sialography findings in 22 dogs with surgically confirmed sialoceles
Authors: Tan Yi Lin , Marques Ana , Schwarz Tobias , Mitchell Jordan , Liuti Tiziana 
Published: May 2022

AbstractSialoceles are an uncommon canine salivary gland disease, and complete surgical resection is important for a positive outcome. Radiographic sialography has been described as a diagnostic test for presurgical planning; however, superimposition artifacts may limit the diagnosis and detection of all affected glands. Computed tomographic (CT) sialography is a promising technique for delineating the salivary gland apparatus. The aims of this retrospective, observational study were to describe clinical and CT sialographic findings in a group of dogs with confirmed sialoceles, to determine the sensitivity of CT sialography for detecting affected salivary glands using surgery as the reference standard and to determine interobserver agreement for CT sialographic assessments. Dogs were included if they underwent a CT sialography study followed by surgical resection of the diseased gland(s) and histopathological analysis. Computed tomography sialography studies of dogs with surgically confirmed sialoceles (n = 22) were reviewed by a European College of Veterinary Diagnostic Imaging (ECVDI)‐certified radiologist and an ECVDI resident. Interobserver agreement was calculated using Cohen's kappa statistics. CT sialography results were compared to surgical findings to determine sensitivity. Contrast leakage was detected in 12 of 22 dogs (54.5%), with intrasialocele leakage being most frequently observed (7/12, 58.3%). There was substantial agreement (κ = 0.70) between reviewers identifying diseased glands, substantial agreement (κ = 0.62) on the diagnostic quality, and no to slight agreement (к = 0.13) in the detection of contrast leakage. The overall sensitivity of CT sialography to detect surgically confirmed diseased glands was 66.7% (95% confidence interval: 48.8‐80.8). In conclusion, these findings support the use of CT sialography as an adjunct diagnostic test for treatment planning in dogs with sialoceles.
A Generalized Variational Method and Its Applications in Design of the Single-Jack Flexible Nozzle
Authors: Li Zhi , Yu Chengguo , Meng LiCheng , Qi Luqiao , Qiu Jian , Shi Yan , Gao Cunfa 
Published: May 2022

Abstract
Nozzle facilities, which can generate high Mach number flows, are the core portions of the supersonic wind tunnel. Different from traditional fixed nozzles, a flexible nozzle can deform to designed contours and supply steady core flows in several Mach numbers. Due to the high-quality demands from the thermo-aerodynamic testing, the deformation of the flexible nozzle plate should be carefully designed. This problem is usually converted into the large deformation problem of a cantilever with movable hinge boundary conditions. In this paper, a generalized variational method is established to analyze the deformation behavior of the flexible nozzle. By introducing axial deformation constraint and Lagrange multiplier, an analytical model is derived to predict the deformed morphology of the flexible plate. Finite element analyses (FEA) of a single-jack flexible nozzle model is performed to examine the predicted deformations and reaction forces. Furthermore, the large deformation experiments of an elastic cantilever with a movable hinge connection are carried out to simulate the scenarios in supersonic flexible nozzle facility. Both the FEA and experimental results show high accuracy of current theoretical model in deformation predictions. This method can also serve as a general approach in the design of flexible mechanisms with movable boundaries.
A Comprehensive Review on Experimental Conditions, Strategies, Performance, and Applications of Incremental Forming for Deformation Machining
Authors: Mandaloi Gangaram , Nagargoje Aniket , Gupta Ankit Kumar , Banerjee Gaurabh , Shahare Harshal Y. , Tandon Puneet 
Published: May 2022

Abstract
The demand for product customization and flexible manufacturing techniques is growing day by day to meet the rapid changes in customer requirements. The current review presents the developments in the domains of incremental sheet forming (ISF) and deformation machining (DM) strategies to obtain thin monolithic geometries. The study focuses on the literature on room temperature single point incremental forming that can be applied to the DM. Thin structural parts are challenging to produce by machining because they have inadequate static and dynamic stiffness and low thermal stability. Significant research work on the evolution of diverse theories that emerged to address the fundamental mechanisms of ISF and DM processes has been reported in the literature. This paper presents an outline of the significant process and response parameters, experimental strategies, deformation mechanics and fracture behavior, toolpath generation techniques, and processes’ applications. The paper reports the motivation, research directions, existing gaps, and expansion in the domains of DM processes. The paper also outlines the evolution of incremental forming for deformation machining in the context of future critical applications in the domains of biomedical, aerospace, and automotive engineering.
Discovering a Failure Taxonomy for Early Design of Complex Engineered Systems Using Natural Language Processing
Authors: Andrade Sequoia R. , Walsh Hannah S. 
Published: May 2022

Abstract
Methodologies for failure assessment frequently rely on historical failure modes, causes, and recommendations for prevention. Meanwhile, there are growing databases of narrative-based lessons that are under-utilized due to their size. Advances in natural language processing (NLP) enable unsupervised extraction of this knowledge. We present a methodology for (1) identifying relevant information using a term frequency inverse document frequency (TF-IDF) classifier and (2) extracting knowledge for failure assessment using a hierarchical topic modeling approach, hierarchical latent Dirichlet allocation (LDA). To interpret the extracted topics, we apply an automatic topic labeling technique using pointwise mutual information (PMI) extraction. The methodology is applied to NASA’s Lessons Learned Information System (LLIS), which is publicly available. Partitioned topics enable the extraction of three aspects: cause, failure, and recommendation, while a hierarchy enables organization into a taxonomy. The methodology is generalizable to databases containing narrative-style documents, while the results from the LLIS represent a summary of themes in the dataset, expressed in a format that can be linked to early design failure analyses.
Cross-sectional association between gamma-glutamyl transferase and hyperuricaemia: the China Multi-Ethinic Cohort (CMEC) study
Authors: Wang Yanjiao , Xu Fang , Zhang Xuehui , Mi Fei , Qian Ying , Hong Rudan , Zou Wei , Bai Hua , He Likun , Wang Songmei , Yin Jianzhong 
Published: May 2022

ObjectivesSeveral studies have demonstrated the association between gamma-glutamyl transferase (GGT) and hyperuricaemia, but little is known about such relation in less-developed ethnic minority regions.DesignWe cross-sectionally analysed data from the China Multi-Ethnic Cohort (Yunnan region).SettingCross-sectional study.Participants22 020 participants aged 30–79 years from Han ethnicity, Yi ethnicity and Bai ethnicity.OutcomesThe serum level of uric acid, GGT and other metabolic parameters were tested. Weight, height and blood pressure were measured. Smoking, drinking, ethnicity, education and medical history were obtained from questionnaires.ResultsIn the crude model, compared with the lowest quintile, the second, third, fourth and fifth quintiles of serum GGT exhibited a positive association with hyperuricaemia risk (OR=1.69, 2.90, 4.34 and 7.70, 95% CI=1.42 to 2.01, 2.47 to 3.42, 3.71 to 5.09 and 6.60 to 8.98, respectively, p-trend<0.0001). In fully adjusted model, compared with the lowest quintile, the second, third, fourth and fifth quintiles of serum GGT also exhibited a positive association with hyperuricaemia risk (OR=1.26, 1.68, 2.02 and 3.02, 95% CI=1.04 to 1.51, 1.40 to 2.00, 1.69 to 2.42 and 2.51 to 3.64, respectively, p-trend<0.0001). Logistic regression model was conducted separately in ethnic groups. Compared with first quintile, the highest GGT level were related to higher risk of hyperuricaemia in three ethnic groups (OR (95% CI): 2.89 (2.26 to 3.68), 2.81 (1.93 to 4.11) and 3.04 (1.91 to 4.84) for Han, Yi and Bai ethnicity, respectively, p-trend <0.0001). The relationship between GGT and hyperuricaemia was also observed in different age groups or gender groups.ConclusionsHigh serum GGT level was related to a higher risk of hyperuricaemia in less-developed ethnic minority regions in China.
Benefits and limitations of business process model notation in modelling patient healthcare trajectory: a scoping review protocol
Authors: Kassim Said Abasse , Gartner Jean-Baptiste , Labbé Laurence , Landa Paolo , Paquet Catherine , Bergeron Frédéric , Lemaire Célia , Côté André 
Published: May 2022

IntroductionThe adoption of business process model notation (BPMN) in modelling healthcare trajectory can enhance the efficiency and efficacy of healthcare organisations, improve patient outcomes while restraining costs. Existing systematic reviews have been inconclusive regarding the effectiveness of BPMN in modelling healthcare trajectory. The aims of this scoping review are to map and aggregate existing evidence on the benefits and limitations associated with BPMN in healthcare trajectory, highlighting areas of improvement on BPMN and its extensions in healthcare. We will assess BPMN’s ability to model key dimensions or concepts of the healthcare process and to meet the needs of stakeholders. The review will highlight the advantages of this approach to support clinical activities and decision-making processes associated with the healthcare trajectory, proposing a conceptual framework for improving the use of BPMN in healthcare.Methods and analysisThis study will be performed in accordance with the methodological framework suggested by Arksey and O’Malley. A wide range of electronic databases and grey literature sources will be systematically searched using predefined keywords. The review will include any study design focusing on the application of the BPMN approach for optimising healthcare trajectories, published in either English or French from 1 January 2004 to 9 December 2021. Two reviewers will independently screen titles, abstracts and full-text articles and select articles meeting the inclusion criteria. A customised data extraction form will be used to extract data. The results will be presented using descriptive statistics and thematic analysis on qualitative data.Ethics and disseminationResearch ethics approval is not required. Review findings will be used to advance understanding about BPMN, its extensions and application in healthcare trajectory optimisation. The review will develop recommendations on tailoring BPMN strategies for optimising care pathways and decision-making processes. Findings will be disseminated in peer-reviewed journals, conferences and discussions with relevant organisations and stakeholders.
Accuracy of blood-based biomarkers for screening precancerous colorectal lesions: a protocol for systematic review and meta-analysis
Authors: Lathlean Timothy J H , Wassie Molla M , Winter Jean M , Goyal Rishabh , Young Graeme P , Symonds Erin L 
Published: May 2022

IntroductionColorectal cancer (CRC) is the third most diagnosed cancer and the second most common cause of cancer mortality worldwide. Most CRCs develop through either the adenoma-to-carcinoma or the serrated pathways, and, therefore, detection and removal of these precursor lesions can prevent the development of cancer. Current screening programmes can aid in the detection of CRC and adenomas; however, participation rates are suboptimal. Blood-based biomarkers may help to address these low participation rates in screening programmes. Although blood-based biomarker tests show promise for cancer detection, limited attention has been placed on the sensitivity and specificity for detection of the precursor lesions. The aim of this research is to conduct a systematic review and meta-analysis to evaluate the accuracy of blood-based biomarker tests in detecting advanced precancerous lesions.Methods and analysisThis protocol was informed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-Protocols (PRISMA-P) and results will be reported in line with the PRISMA guidelines. Literature searches will be conducted on PubMed, Embase and Web of Science. Two reviewers will conduct the searches, and independently screen them, according to title and abstract and then the full-text versions of those selected articles as well as the risk of bias via the Quality Assessment of Diagnostic Accuracy Studies version 2 (QUADAS-2) tool. The Grading of Recommendations Assessment, Development and Evaluation guidelines will be used to validate the certainty of evidence for recommendations based on the risk of bias findings. Meta-analysis will be conducted where appropriate on groups of studies with low heterogeneity.Ethics and disseminationNo patient data will be included in our review and, therefore, ethics approval is not required. It is anticipated that the review will identify the most promising candidate biomarkers for clinical translation in the screening of advanced precancerous lesions. The results will be published in a peer-reviewed journal.PROSPERO registration numberCRD42021285173.
Multicentre observational study on practice of prehospital management of hypotensive trauma patients: the SPITFIRE study protocol
Authors: Tartaglione Marco , Carenzo Luca , Gamberini Lorenzo , Lupi Cristian , Giugni Aimone , Mazzoli Carlo Alberto , Chiarini Valentina , Cavagna Silvia , Allegri Davide , Holcomb John B , Lockey David , Sbrana Giovanni , Gordini Giovanni , Coniglio Carlo 
Published: May 2022

IntroductionMajor haemorrhage after injury is the leading cause of preventable death for trauma patients. Recent advancements in trauma care suggest damage control resuscitation (DCR) should start in the prehospital phase following major trauma. In Italy, Helicopter Emergency Medical Services (HEMS) assist the most complex injuries and deliver the most advanced interventions including DCR. The effect size of DCR delivered prehospitally on survival remains however unclear.Methods and analysisThis is an investigator-initiated, large, national, prospective, observational cohort study aiming to recruit >500 patients in haemorrhagic shock after major trauma. We aim at describing the current practice of hypotensive trauma management as well as propose the creation of a national registry of patients with haemorrhagic shock. Primary objective: the exploration of the effect size of the variation in clinical practice on the mortality of hypotensive trauma patients. The primary outcome measure will be 24 hours, 7-day and 30-day mortality. Secondary outcomes include: association of prehospital factors and survival from injury to hospital admission, hospital length of stay, prehospital and in-hospital complications, hospital outcomes; use of prehospital ultrasound; association of prehospital factors and volume of first 24-hours blood product administration and evaluation of the prevalence of use, appropriateness, haemodynamic, metabolic and effects on mortality of prehospital blood transfusions. Inclusion criteria: age >18 years, traumatic injury attended by a HEMS team including a physician, a systolic blood pressure <90 mm Hg or weak/absent radial pulse and a confirmed or clinically likely diagnosis of major haemorrhage. Prehospital and in-hospital variables will be collected to include key times, clinical findings, examinations and interventions. Patients will be followed-up until day 30 from admission. The Glasgow Outcome Scale Extended will be collected at 30 days from admission.Ethics and disseminationThe study has been approved by the Ethics committee ‘Comitato Etico di Area Vasta Emilia Centro’. Data will be disseminated to the scientific community by abstracts submitted to international conferences and by original articles submitted to peer-reviewed journals.Trial registration numberNCT04760977.
Adaptive divergence of lateral plate ultrastructure in threespine stickleback (Gasterosteus aculeatus)
Authors: Wertman Debra L. , Reimchen Thomas E. 
Published: May 2022

The lateral plates of threespine stickleback ( Gasterosteus aculeatus Linnaeus, 1758) are well studied for their adaptive morphological responses to predators, yet it is unknown whether habitat influences plate ultrastructure. We investigated using scanning electron microscopy the lateral plate ultrastructure (tubercles and ridges) of stickleback ( N = 61 adult fish) from nine Haida Gwaii (coastal British Columbia, Canada) wild-type populations, two experimental transplants, and two lab-reared cohorts reared from source populations. Tubercle density, but not ridge density, differed significantly across habitat types and populations. Among wild-type fish, tubercle densities were greatest in dystrophic habitats containing predatory fish, and lowest in weakly dystrophic systems featuring bird–invertebrate predation and marine populations with diverse predatory fish. No differences in tubercle density were detected between source and transplant populations, despite major habitat shifts. Lab-reared fish exhibited significantly lower tubercle densities than their source populations (less than one generation). Tubercle density differences across habitat types may reflect adaptation to divergent predation regimes, with tooth-bearing predators selecting for denser tubercles that disperse point forces. Conservation of ridge density across populations suggests an essential function in dispersing forces applied to dorsal spines during predator manipulation. Lateral plate ultrastructure in threespine stickleback thus results from both heritable effects and developmental plasticity.
Resonances in heavy meson–heavy baryon coupled-channel interactions
Authors: Wang Zheng-Li , Shen Chao-Wei , Rönchen Deborah , Meißner Ulf-G. , Zou Bing-Song 
Published: May 2022

AbstractThe interactions of $${\bar{D}}^{(*)} \Lambda _c - {\bar{D}}^{(*)}\Sigma _c^{(*)}$$

D

¯

(

∗
)

Λ
c

-

D

¯

(

∗
)

Σ
c

(

∗
)

are studied within the framework of a dynamical coupled-channel approach. A series of bound states and resonances with different spin and parity are dynamically generated in the hidden charm sector. Four S-wave bound states are found in the mass range of 4.3–4.5 GeV, close to the pentaquark states observed by LHCb. Two of the states have a spin parity of $$J^P= 1/2^-$$

J
P

=
1
/

2
-

and the other two have $$J^P=3/2^-$$

J
P

=
3
/

2
-

. In addition, several resonances with different spin and parity in higher partial waves are predicted.
New models to aid the discovery of critical raw material deposits for the Green Stone Age
Authors: Bidgood Anna , Hitzman Murray 
Published: May 2022

Abstract
Critical raw materials (CRMs) will be crucial for delivery of the technologies society requires to meet its decarbonization goals and successfully address the current climate crisis. Although there are a number of well-established ore deposit models, few have been developed for CRMs. History demonstrates that ore deposit models are commonly developed to explain new discoveries. However, it is also possible to develop new ore deposit models based solely on basic geochemical and geological principles. We review the development of several ore deposit models, suggest some deposits for which models have not yet been developed and utilize the specific example of hydrothermal nickel deposits in the Central African Copperbelt to illustrate how new ore deposit models for CRM deposits may be formulated. The current impetus to discover new resources of what have been up to the present elemental curiosities should spur significant research, including work to determine the geochemical behaviour of CRMs across a range of physio-chemical conditions. There is no reason to believe that economically significant concentrations of any of the newly critical elements do not exist in nature. Imagination should make the future of CRM discovery in the Green Stone age bright.
The Neotropical ant-parasitic genus Neodohrniphora Malloch (Diptera: Phoridae): a taxonomic revision with seven new species and key to species
Authors: Pereira Thalles Platiny Lavinscky , Brown Brian V. , Nihei Silvio S. 
Published: May 2022

Abstract
The Neotropical ant-parasitic genus Neodohrniphora Malloch is revised based on female specimens. Herein, eleven species are studied, seven of which are new to science: N. canina sp. nov., N. gigantea sp. nov., N. mokana sp. nov., N. pseudoacromyrmecis sp. nov., N. queirozi sp. nov., N. rapunzelae sp. nov., and N. truncata sp. nov. Neodohrniphora wasmanni Borgmeier is revalidated and two new synonymies are proposed: N. similis Prado is synonymized with N. acromyrmecis Borgmeier, and N. unichaeta Disney is synonymized with N. wasmanni Borgmeier. In order to provide stability and a necessary standard for comparison, a neotype for N. cognata Prado is designated based on material collected from the same type locality, data, and collector as the now lost or destroyed holotype. A new key for all the females of Neodohrniphora, new host records, and details of ovipositor morphology are provided.