bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wacana Kapitalisme Dalam Penyelenggaraan Halal Expo Japan
Authors: Sari Yulia , Fitriana Rina , Susanti Helen 
Published: June 2022

Abstrak Penelitian ini membahas mengenai wacana kapitalisme dalam penyelenggaraan Halal Expo Japan, khususnya tahun 2016 dan 2017. Tema ini dipilih karena penulis melihat dalam penyelenggarannya, Halal Expo Japan menjadi media kapitalisme bagi Jepang. Penulis menggunakan konsep kapitalisme Karl Marx untuk menganalisis kapitalisme dalam penyelenggaraan Halal Expo Japan. Metode yang digunakan adalah metode kualitatif dan teknik penelitian studi pustaka dengan data yang diperoleh dari laman web Halal Expo Japan yaitu www.halalexpo.jp, pemberitaan dari co-organizer dan media partner resmi Halal Expo Japan, Halal Media Japan Co. Ltd. dari laman web www.halalmedia.jp serta buku-buku teks, artikel dan publikasi elektronik yang ada hubungannya dengan Halal Expo Japan serta teori kapitalisme dan teori kekuasaan. Hasilnya menunjukkan meskipun terdapat banyak konten acara dalam Halal Expo Japan namun bila dicermati secara lebih mendalam dan kritis dapat terlihat baik konten- konten dalam laman web maupun Post Report Show lebih berfokus mengenai pameran, seminar serta fashion show, yang merupakan produk dari kapitalisme. Adanya peluang yang besar dalam industri halal, para kapitalis atau pemegang modal di Jepang memanfaatkannya untuk mengembangkan produk halal sebagai sumber pemasukan bagi Jepang.Kata Kunci: Halal Expo Japan, Industri Halal, Kekuasaan, Kapitalisme, Kapitalis
Konsep Keindahan Wabi Sabi Dalam Puisi Karya Nakahara Chuuya
Authors: Muthmainnah Endah , Mugiyanti Mugiyanti , Rukhyana Budi 
Published: June 2022

Penelitian ini akan menganalisis dua buah puisi karya Nakahara Chuuya yang berjudul kita no umi, dan tsukiyou no hamabe. Konsep keindahan dakan dianalisis dengan menggunakan konsep Wabi Sabi. Penelitian ini menggunakan metode analisis deskriptif dan studi pustaka Hasil analisis menunjukkan bahwa ketiga puisi karya Nakahara Chuuya memiliki enam ciri konsep keindahan Wabi Sabi yaitu Kanashiku, Shitsui, Sabu, samu, sabishiki (futanoshiki)), Irosokukū no sekai), Mazushiku, dan Mazushisa wo yutaka to nashi.
Multi-Scale Process Monitoring Based on Time-Frequency Analysis and Feature Fusion
Authors: Ji Cheng , Tao Tingting , Wang Jingde , Sun Wei 
Published: June 2022

Data-driven process monitoring is an important tool to ensure safe production and smooth operation. Generally, implicit information can be mined through data processing and analysis algorithms to detect process disturbances on the basis of historical production data. In industrial practice, signals with different sources of disturbance show different distribution patterns along with the time domain and frequency domain, that is, noise and pulse-type changes are usually contained in the high-frequency portion while most process dynamic is contained in the low-frequency portion. However, feature extraction is usually implemented at a single scale in traditional multivariate statistical algorithms. With this concern, a novel multi-scale process monitoring method is proposed in this work, by which wavelet packet decomposition is first employed for time-frequency analysis. After decomposition, multivariate statistical models are established for each scale to construct process statistics. For the high-frequency part, the classical principal component analysis (PCA) algorithm is adopted to construct squared prediction error (SPE) and Hotelling T2(T2) statistics. While for the low-frequency part, the slow feature analysis (SFA) algorithm is adopted to construct T2, Te2, S2 and Se2 statistics for the extraction of the long-term slowly changing trend. Then the monitoring statistics, obtained from each method at different scales, are integrated by a support vector data description (SVDD) method to give a final fault detection decision. The performance of the proposed method is verified on the benchmark Tennessee Eastman Process (TEP) and an industrial continuous catalytic reforming heat exchange unit by comparing with related multivariate statistical methods, which only focus on a single scale.
Apatites Record Sedimentary Provenance Change 4–5 Myrs Before Clay in the Oligocene/Miocene Alpine Molasse
Authors: Hülscher Julian , Sobel Edward R. , Kallnik Niklas , Hoffmann J. Elis , Millar Ian L. , Hartmann Kai , Bernhardt Anne 
Published: June 2022

Extracting information about past tectonic or climatic environmental changes from sedimentary records is a key objective of provenance research. Interpreting the imprint of such changes remains challenging as signals might be altered in the sediment-routing system. We investigate the sedimentary provenance of the Oligocene/Miocene Upper Austrian Northern Alpine Foreland Basin and its response to the tectonically driven exhumation of the Tauern Window metamorphic dome (28 ± 1 Ma) in the Eastern European Alps by using the unprecedented combination of Nd isotopic composition of bulk-rock clay-sized samples and partly previously published multi-proxy (Nd isotopic composition, trace-element geochemistry, U-Pb dating) sand-sized apatite single-grain analysis. The basin offers an excellent opportunity to investigate environmental signal propagation into the sedimentary record because comprehensive stratigraphic and seismic datasets can be combined with present research results. The bulk-rock clay-sized fraction εNd values of well-cutting samples from one well on the northern basin slope remained stable at ∼−9.7 from 27 to 19 Ma but increased after 19 Ma to ∼−9.1. In contrast, apatite single-grain distributions, which were extracted from 22 drill-core samples, changed significantly around 23.3 Ma from apatites dominantly from low-grade (&lt;upper amphibolite-facies) metamorphic sources with Permo-Mesozoic and late Variscan U-Pb ages and εNd values of −4.4 to dominantly high-grade metamorphic apatites with late Variscan U-Pb ages and εNd values of −2.2. The change in apatite single-grain distributions at 23.3 Ma is interpreted to result from the exposure of a new Upper Austroalpine source nappe with less negative εNd values triggered by the ongoing Tauern Window exhumation. Combining these data with the clay-sized bulk-rock εNd values reveals that the provenance changed 4–5 Myrs later at 19 Ma in the clay-sized fraction. Reasons for the delayed provenance-change recording are rooted in the characteristics of the applied methods. Whereas single-grain distributions of orogen-wide sediment-routing systems can be dominated by geographically small areas with high erosion and mineral fertility rates, bulk-rock methods integrate over the entire drainage basin, thus diminishing extreme values. Hence, by combining these two methods, spatial information are uncovered, enabling a previously unattained understanding of the underlying environmental change.
Admission Blood Glucose and 2-Year Mortality After Acute Myocardial Infarction in Patients With Different Glucose Metabolism Status: A Prospective, Nationwide, and Multicenter Registry
Authors: Cui Kongyong , Fu Rui , Yang Jingang , Xu Haiyan , Yin Dong , Song Weihua , Wang Hongjian , Zhu Chenggang , Feng Lei , Wang Zhifang , Wang Qingsheng , Lu Ye , Dou Kefei , Yang Yuejin 
Published: June 2022

BackgroundThe prognostic effect of admission blood glucose (ABG) for patients with acute myocardial infarction (AMI) has not been well validated, especially in patients with diabetes. We performed this study to assess the predictive value of ABG for all-cause mortality in AMI patients with different glucose metabolism status.MethodsWe evaluated a total of 6,892 AMI patients from the prospective, nationwide, multicenter CAMI registry, of which 2,820 had diabetes, 2,011 had pre-diabetes, and 2,061 had normal glucose regulation (NGR). Patients were divided into high ABG and low ABG groups according to the optimal cutoff values of ABG to predict 2-year mortality for patients with diabetes, pre-diabetes and NGR, respectively. The primary endpoint was all-cause mortality.ResultsThe optimal cutoff values of ABG for predicting 2-year mortality was 9.0mmol/l, 7.2mmol/l and 6.2mmol/l for patients with diabetes, pre-diabetes and NGR, respectively. Overall, the risk of all-cause mortality in high ABG group was significantly increased compared with that in low ABG group among patients with diabetes (15.2% vs. 8.9%; hazard ratio [HR] 1.787, 95% confidence interval [CI] 1.413-2.260; P&lt;0.0001), pre-diabetes (12.1% vs. 6.1%; HR 2.069, 95%CI 1.518-2.821; P&lt;0.0001) and NGR (11.8% vs. 6.1%; HR 2.009, 95%CI 1.473-2.740; P&lt;0.0001). After the potential confounders were adjusted, high ABG was significantly associated with higher risk of 2-year mortality in patients with diabetes (adjusted HR 1.710, 95%CI 1.327-2.203; P&lt;0.0001), pre-diabetes (adjusted HR 1.731, 95%CI 1.249-2.399; P=0.001) and NGR (adjusted HR 1.529, 95%CI 1.110-2.106; P=0.009). Moreover, adding ABG to the original model led to a slight albeit significant improvement in C-statistic and net reclassification in patients with diabetes and NGR (all P&lt;0.05).ConclusionsThis study is the first to demonstrate a strong positive association between ABG and 2-year mortality in AMI patients with diabetes, pre-diabetes and NGR. ABG should be considered as a useful marker for risk stratification in patients with diabetes and NGR. Further randomized trials are warranted to investigate the effects of blood glucose control on the reduction of long-term mortality according to the corresponding ABG thresholds for different glucose metabolism status.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT01874691.
Sustainable Development of Enterprises in Conditions of Smart Ecology: Analysis of The Main Problems and Development of Ways to Solve Them, Based on Artificial Intelligence Methods and Innovative Technologies
Authors: Skiter Natalia N. , Rogachev Aleksey F. , Ketko Nataliya V. , Simonov Aleksey B. , Tarasova Irina A. 
Published: June 2022

Relevance: Currently, the sustainability and profitability of any company is directly related to its interaction with the environment. In the 20th century it was believed that stable development is impossible, if the company focuses its production on the preservation and protection of the environment. Since the second half of the 20th century, ideas have been increasingly heard that sustainable economic development cannot be achieved at the expense of the predatory depletion of natural resources. The environmental agenda plays an important role in the ESG principles, largely formulated by UN Secretary-General Kofi Annan, reflected in Sustainable Development Goals 12–15, reflected in Resolution 70/1 - Transforming our world: the 2030 Agenda for Sustainable Development. Companies such as Tesla Motors, called “green giants”, have proven by their experience and development dynamics that in today’s environment a business that does not have a negative impact on the environment can be profitable and successful. Thus, modern trends in the development of the world economy determine the relevance of the present study, aimed at studying the new conditions of economic activity by enterprises - the conditions of smart ecology and development of recommendations for the effective transformation of enterprises under these conditions. The purpose of this study is to analyze and identify the main problems of sustainable development of enterprises in terms of preservation and protection of the environment - “smart ecology”, and based on the formulated problems the authors have developed ways to overcome them. The subject of the study are managerial and other relationships arising during the implementation of innovative Smart projects by enterprises.Methods: In the process of analyzing the problems and developing ways to overcome them and the transition of enterprises to the conditions of smart ecology, the authors used methods of system analysis, methods of statistical analysis, methods of artificial intelligence.Results: The conducted analysis shows that in modern conditions of development of innovative technologies in Russia there is no unified approach to the process of effective management of breakthrough development projects. The analysis proposed the concept of SMART ecology and showed its importance for understanding the processes taking place in the modern world. Factors influencing the effectiveness of the implementation of innovative smart ecology projects have been identified. Methods that can be used during the implementation of these projects were proposed.
Deep Learning-Based Pathology Image Analysis Enhances Magee Feature Correlation With Oncotype DX Breast Recurrence Score
Authors: Li Hongxiao , Wang Jigang , Li Zaibo , Dababneh Melad , Wang Fusheng , Zhao Peng , Smith Geoffrey H. , Teodoro George , Li Meijie , Kong Jun , Li Xiaoxian 
Published: June 2022

BackgroundOncotype DX Recurrence Score (RS) has been widely used to predict chemotherapy benefits in patients with estrogen receptor-positive breast cancer. Studies showed that the features used in Magee equations correlate with RS. We aimed to examine whether deep learning (DL)-based histology image analyses can enhance such correlations.MethodsWe retrieved 382 cases with RS diagnosed between 2011 and 2015 from the Emory University and the Ohio State University. All patients received surgery. DL models were developed to detect nuclei of tumor cells and tumor-infiltrating lymphocytes (TILs) and segment tumor cell nuclei in hematoxylin and eosin (H&amp;E) stained histopathology whole slide images (WSIs). Based on the DL-based analysis, we derived image features from WSIs, such as tumor cell number, TIL number variance, and nuclear grades. The entire patient cohorts were divided into one training set (125 cases) and two validation sets (82 and 175 cases) based on the data sources and WSI resolutions. The training set was used to train the linear regression models to predict RS. For prediction performance comparison, we used independent variables from Magee features alone or the combination of WSI-derived image and Magee features.ResultsThe Pearson’s correlation coefficients between the actual RS and predicted RS by DL-based analysis were 0.7058 (p-value = 1.32 × 10–13) and 0.5041 (p-value = 1.15 × 10–12) for the validation sets 1 and 2, respectively. The adjusted R2 values using Magee features alone are 0.3442 and 0.2167 in the two validation sets, respectively. In contrast, the adjusted R2 values were enhanced to 0.4431 and 0.2182 when WSI-derived imaging features were jointly used with Magee features.ConclusionOur results suggest that DL-based digital pathological features can enhance Magee feature correlation with RS.
Transcallosal and Corticospinal White Matter Disease and Its Association With Motor Impairment in Multiple Sclerosis
Authors: Yoon Keejin , Archer Derek B. , Clarke Margareta A. , Smith Seth A. , Oguz Ipek , Cutter Gary , Xu Junzhong , Bagnato Francesca 
Published: June 2022

PurposeIn this cross-sectional, proof-of-concept study, we propose that using the more pathologically-specific neurite orientation dispersion and density imaging (NODDI) method, in conjunction with high-resolution probabilistic tractography, white matter tract templates can improve the assessment of regional axonal injury and its association with disability of people with multiple sclerosis (pwMS).MethodsParametric maps of the neurite density index, orientation dispersion index, and the apparent isotropic volume fraction (IVF) were estimated in 18 pwMS and nine matched healthy controls (HCs). Tract-specific values were measured in transcallosal (TC) fibers from the paracentral lobules and TC and corticospinal fibers from the ventral and dorsal premotor areas, presupplementary and supplementary motor areas, and primary motor cortex. The nonparametric Mann–Whitney U test assessed group differences in the NODDI-derived metrics; the Spearman's rank correlation analyses measured associations between the NODDI metrics and other clinical or radiological variables.ResultsIVF values of the TC fiber bundles from the paracentral, presupplementary, and supplementary motor areas were both higher in pwMS than in HCs (p ≤ 0.045) and in pwMS with motor disability compared to those without motor disability (p ≤ 0.049). IVF in several TC tracts was associated with the Expanded Disability Status Scale score (p ≤ 0.047), while regional and overall lesion burden correlated with the Timed 25-Foot Walking Test (p ≤ 0.049).ConclusionIVF alterations are present in pwMS even when the other NODDI metrics are still mostly preserved. Changes in IVF are biologically non-specific and may not necessarily drive irreversible functional loss. However, by possibly preceding downstream pathologies that are strongly associated with disability accretion, IVF changes are indicators of, otherwise, occult prelesional tissue injury.
Long-Term Efficacy of Non-steroid Immunosuppressive Agents in Anti-Muscle-Specific Kinase Positive Myasthenia Gravis Patients: A Prospective Study
Authors: Tan Ying , Shi Jiayu , Huang Yangyu , Li Ke , Yan Jingwen , Zhu Li , Guan Yuzhou , Cui Liying 
Published: June 2022

Background and PurposeAnti-muscle-specific kinase (MuSK) positive myasthenia gravis (MG) is characterized by a high relapsing rate, thus, choosing the appropriate oral drug regimen is a challenge. This study aimed to evaluate the efficacy of oral immunosuppressants (IS) in preventing relapse in MuSK-MG.MethodsThis prospective cohort observational study included patients with MuSK-MG at Peking Union Medical College Hospital between January 1, 2018, and November 15, 2021. The patients were divided into 2 groups: those with (IS+) or without (IS-) non-steroid immunosuppressive agents. The primary outcome was relapsed at follow-up, and the log-rank test was used to compare the proportion of maintenance-free relapse between the groups; hazard ratio (HR) was calculated using the Cox proportional hazards models.ResultsFifty-three of 59 patients with MuSK-MG were included in the cohort, 14 were in the IS+ group, and 39 were in the IS- group. Twenty-four cases in the cohort experienced relapse at least once; the relapse rate was 2/14 (14.3%) in the IS+ group and 22/39 (56.4%) in the IS- group. At the end of follow-up, the proportion of maintenance-free relapse was significantly different between the two groups (log-rank χ2 = 4.94, P = 0.02). Of all the potential confounders, only the use of IS was associated with a reduced risk of relapse. The HR for relapse among patients in the IS+ group was 0.21 (95%CI 0.05–0.58) and was 0.23 (95%CI 0.05–0.93) in a model adjusted for age, sex, relapse history, highest Myasthenia Gravis Foundation of America (MGFA), and accumulated time of steroid therapy.ConclusionsThis study provides evidence that oral non-steroid immunosuppressive agents may be beneficial in reducing relapse in patients with MuSK-MG.
Energy-Adjusted Dietary Inflammatory Index Is Associated With 5-Year All Cause and Cardiovascular Mortality Among Chronic Kidney Disease Patients
Authors: Huang Ying , Zhang Lei , Zeng Mengru , Liu Fuyou , Sun Lin , Liu Yu , Xiao Li 
Published: June 2022

BackgroundDiet management is a pivotal intervention for chronic kidney disease (CKD) patients. Dietary inflammation index (DII) is developed to evaluate the integral inflammatory potential of a diet pattern. However, research about the association between DII and mortality in CKD is limited.ObjectiveWe conducted a cohort study to investigate the relationship between energy-adjusted DII (E-DII) and the 5-year all-cause and cardiovascular mortality in CKD population.Materials and MethodsCKD participants with complete E-DII data and death status from National Health and Nutrition Examination Survey (1999–2014) were involved in this study. E-DII was calculated based on dietary recall interviews. Smooth curve fitting, Kaplan–Meier survival analysis, and Cox proportional hazards models were used to evaluate the association between E-DII and the 5-year all cause and cardiovascular mortality. Subgroup analysis was also performed.ResultsA total of 7,207 participants were included (55.46% elderly and 46.54% male) in this study. The 5-year all-cause and cardiovascular mortality were 16.86 and 4.32%, respectively. Smooth curve fitting showed a “J” shape and near linear relationship between the E-DII score and the 5-year all-cause and cardiovascular mortality, respectively. In multivariate Cox proportional hazards models, the hazard ratios (95% confidence intervals [CI]) for the highest tertile of the E-DII were 1.33 (1.15, 1.54) for all-cause mortality, and 1.54 (1.15, 2.07) for cardiovascular mortality when compared with the lowest tertile of the E-DII. The subgroup analyses revealed relatively stronger associations between the E-DII and the mortality among CKD patients with other death risk factors.ConclusionsEnergy-adjusted dietary inflammatory index is independently related with the 5-year all-cause and cardiovascular mortality among CKD patients. Therefore, anti-inflammatory diet patterns should be recommended for CKD patients.
Beyond Crizotinib: A Systematic Review and Meta-Analysis of the Next-Generation ALK Inhibitors as First-Line Treatment for ALK-Translocated Lung Cancer
Authors: Giunta Emilio Francesco , Signori Alessio , West Howard Jack , Metro Giulio , Friedlaender Alex , Parikh Kaushal , Banna Giuseppe Luigi , Addeo Alfredo 
Published: June 2022

BackgroundSecond and third-generation ALK inhibitors (ALKIs) have been recently approved for ALK-translocated lung cancer treatment, improving - and expanding - the first-line scenario.MethodsIn this systematic review and metanalysis, we investigated the efficacy and safety of next-generation ALKIs in untreated advanced ALK-translocated lung cancer patients, searching for randomized phase III controlled trials through databases (PubMed, EMBASE, and the Cochrane Library). Inclusion and exclusion of studies, quality assessment, data extraction, and synthesis were independently accomplished by two reviewers, with discrepancies adjudicated by a third reviewer. Stata (StataCorp., v.16) software was used for the metanalysis.ResultsIn total, seven randomized controlled trials met our inclusion criteria. Comparing the results of next-generation ALKIs and control therapy (crizotinib or chemotherapy), next-generation ALKIs significantly improved progression-free survival (PFS), overall survival (OS), objective response rate (ORR), disease control rate (DCR), any lesion (aCNSRR) and measurable lesions of central nervous system response rate (mCNSRR). Safety results were similar between the experimental and control groups.ConclusionOur analysis confirmed that next-generation ALKIs are the preferred first-line treatment option for ALK-translocated lung cancer. They are superior to crizotinib or chemotherapy in several clinical endpoints, including OS, PFS, ORR and CNS disease control, without increased toxicity. In the absence of head-to-head data, the choice between these molecules should be guided by physician experience and preference, drug-specific safety profile and schedule.