bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carcinogenic and non-carcinogenic human health risk assessments of heavy metals contamination in drinking water supplies in Iran: a systematic review
Authors: Marufi Nilufar , Oliveri Conti Gea , Ahmadinejad Parvin , Ferrante Margherita , Mohammadi Ali Akbar 
Published: October 2022

Abstract
The contamination of water due to heavy metals (HMs) is a big concern for humankind; particularly in developing countries. This research is a systematic review, conducted by searching google scholar, Web of Science, Science Direct, PubMed, Springer, and Scopus databases for related published papers from 2010 to July 2021, resulting in including 40 articles. Among the analyzed HMs in the presented review, the average content of Cr, Pb, Ba, Al, As, Zn, and Cd exceeded the permissible limits suggested by the World Health Organization (WHO) and 1,053 Iranian standards. Also, the rank order of Hazard Quotient (HQ) of HMs was defined as Cd>As>Cr>Pb>Li for children which means Cd has the highest non-carcinogenic risk and Li has the least. This verifies to the current order As>Cr>Pb>Fe=Zn=Cu>Cd for adults. The corresponded values of HQ and Hazard Index (HI) in most cities and villages were investigated and the results indicated a lower than 1 value, which means consumers are not at non-carcinogenic risk (HQ). Carcinogenic risk (CR) of As in the adult and children consumers in most of the samples (58.82% of samples for both groups) were investigated too, and it was more than>1.00E-04 value, which determines that consumers are at significant CR.
Source, toxicity and carcinogenic health risk assessment of heavy metals
Authors: Budi Hendrik Setia , Catalan Opulencia Maria Jade , Afra Arghavan , Abdelbasset Walid Kamal , Abdullaev Dilmurod , Majdi Ali , Taherian Masoume , Ekrami Hafez Ajam , Mohammadi Mohammad Javad 
Published: October 2022

Abstract
Heavy metals are chemical elements with unique properties that are toxic even in low concentrations and affect human health with different functions. Agricultural and industrial activities, improper disposal of household solid waste and residues related to industrial producers, discharge of household wastewater and agricultural fertilizers are the most important ways in which toxic heavy metals enter the environment, which harms human health and life. A narrative review of the literature was done from 2000 to 2022 based on searched databases included Google Scholar, PubMed, Springer, Web of Science, and Science Direct (Scopus). All relevant studies published 2000 until 2022 gathered. According to the databases, 820 articles were retrieved. 186 and 50 articles were found and selected based on records identified through database searching and additional records identified through other sources. In the next stage, 97 studies were screened after review and 64 full-text articles entered into the analysis process. Finally, 45 articles were selected in this study. Adverse effects of heavy metals on various conditions in the body depend on a number of factors, including dose, route of exposure and chemical species, as well as age, sex, genetics, nutritional status, and duration of exposure to the heavy metal. The existence of significant relationships between long-term and short-term exposure to toxic heavy metals and their adverse effects, including carcinogenicity, has been extensively studied and proven through numerous experiments. However, the mechanisms associated with this complication have not been properly identified, so in future research, there is a great need for comprehensive studies on the carcinogenicity of heavy metals.
Stress-induced headache in the general working population is moderated by the NRCAM rs2300043 genotype
Authors: Sannes Ann-Christin , Christensen Jan Olav , Nielsen Morten Birkeland , Gjerstad Johannes 
Published: October 2022

Abstract

Objectives
Earlier findings suggest that social stress such as abusive supervision may promote pain. In the present study we examine the possible moderating role of genetic variability in the NRCAM gene in this process.

Methods
The data were collected through a national survey drawn from the National Central Employee Register by Statistics Norway. A total of 1,205 individuals returned both the questionnaire and the saliva kit. Abusive supervision was scored by a 5-item version of the Tepper’s 2,000 scale. Headache was measured on a four-category scale; ‘not bothered,’ ‘a little bothered,’ ‘considerably bothered’, ‘seriously bothered’. Genotyping with regards to NRCAM rs2300043 was carried out using Taqman assay. Ordinal logistic regression was used to analyse the data.

Results
For males exposed to abusive supervision, those carrying the rs2300043 CC genotype reported the highest levels of headache. Women showed a trend towards the opposite pattern. Women with the rs2300043 CC genotype seem to have a weaker effect of abusive supervision regarding reported headache than their male counterparts with the CC genotype when exposed to abusive supervision.

Conclusions
The present results indicated that the association between abusive supervision and headache in men with the NRCAM rs2300043 C allele was stronger than in other men. This suggests that the NRCAM genotype in men is important for the tolerance of social stress e.g., repeated negative acts from a superior. In contrast, a trend, though non-significant, towards the opposite pattern was observed in women. Our result suggests that the NRCAM genotype in men manifestly affects stress-induced pain such as headache.
Comparative Study of the Reactivity and Performance of Different Nontraditional and Natural Pozzolans in Cementitious System
Authors: Tokpatayeva R. , Castillo A. , Yoon J. , Kaladharan G. , Jafari K. , Arachchige R. M. , Rajabipour F. , Peethamparan S. , Olek J. 
Published: October 2022

Abstract
The shortage of conventional supplementary cementitious materials opens up the prospect for broader utilization of nontraditional and natural pozzolans (NNPs). The NNPs used in the study included three calcined clays, three volcanic ashes (also referred to as natural pozzolans), three ground bottom ashes, and two fluidized bed combustion ashes. The study focused on assessment of the performance of these NNPs in portland cement systems by evaluating the following parameters: (a) development of the heat of reaction in cement pastes containing 25, 30, and 35 % of NNPs by weight of cement (bwoc) by means of isothermal calorimetry; (b) measurement of the consumption of calcium hydroxide (CH) in cement pastes containing 0, 25, 30, 35, 40, and 45 % (bwoc) of NNPs after 7, 28, and 56 days of curing using thermogravimetric analysis technique; (c) determination and quantification of the reaction products by quantitative x-ray diffraction in cement pastes containing 0 and 25 % (bwoc) of NNPs after 7, 28, and 56 days of curing; and (d) measurement of the 7- and 28-day compressive strength of mortar cubes. In all cases, the cumulative heat values of pastes containing NNPs were higher than those of reference pastes containing inert fillers, confirming that all NNPs were undergoing pozzolanic reaction. For most of the NNPs, the highest amount of CH consumed was observed in systems with 35 % replacement level. The early-age CH consumption correlated well with the content of alumina in NNPs whereas the later-age data correlated better with the silica content of the NNPs. In terms of compressive strength development, the highest early-age values were observed in mortars containing calcined clays, whereas other NNPs contributed to strength development at latter ages.
Modeling the Particle Breakage via Breakage Energy during Triaxial Shearing
Authors: Jian Fuxian , Li Xiaomei , Guo Wanli 
Published: October 2022

Abstract
Rockfill materials are widely used as foundation in construction and different degrees of particle breakage inevitably show different characteristics. The breakage index (e.g., Marsal breakage index, Bg) of rockfill materials directly measured though experimental method naturally has an intrinsic correlation with the physical description applied by theoretical method (e.g., breakage energy, Eb) for the same process of crushing. Eb back-calculated by the incremental energy equations of Ueng’s models may be violating the law of irreversibility for energy accumulation because they treat the critical friction ratio Mc as a constant. This can be solved by constructing a function express that resets the friction ratio as a variable related to shear strain and critical state friction ratio. By utilizing experimental data of three kinds of granular aggregates, it was found that Bg is proportional to the increase of Eb, regardless of whether shear strains are during shearing or after. The method proposed in this paper can be used to calculate the effect of particle breakage in the whole shear process without multiple tests.
Assessment of soil fertility using the soil fertility index method on several land uses in Tutur District, Pasuruan Regency of East Java
Authors: Sasongko Purnomo Edi , Purwanto Purwanto , Dewi Widyatmani Sih , Hidayat Ramdan 
Published: October 2022

<p>Changes in land use have an impact on the level of soil fertility. Soil management, such as land cover systems and the environment, are supporting factors. Assessment of soil fertility index using indicators of soil chemical properties such as organic C, availability of nutrients nitrogen (N), phosphorus (P), cation exchange capacity (CEC), and exchangeable cations (K, Ca, Mg, Na). The research was conducted in Tutur District, Pasuruan Regency, with a survey of 5 land uses, i.e., mixed crops, coffee plantations, apple plantations, vegetable fields, secondary forests, and conservation forests. Observations were made on elevation, slope, and vegetation. Parameters of physical properties measured were soil texture and aggregate stability. Observations of chemical properties included organic C, N, P, CEC, exchangeable cation (K, Ca, Mg, Na), and soil pH. Soil Fertility Index (SFI) data were analyzed using the Least Significant Difference method at a 5% level. The results showed the diversity of soil fertility levels obtained from the calculation of the soil fertility index. The soil fertility index value in 5 land uses in Tutur District ranged from 0.67 to 1.00. Coffee plantations had the highest SFI score of 1.00; this condition was supported by an organic C indicator of 6.21% and a CEC value of 39.12 cmol kg<sup>-1</sup>. Conservation forest is the land use with the lowest SFI value of 0.67. The value of CEC and cation exchange in conservation forests are factors that impact the low value of SFI. </p>
Response of selected chemical properties of extremely acidic soils on the application of limes, rice husk biochar and zeolite
Authors: Sopha Gina Aliya , Hermanto Catur , Kerckhoffs Huub , Heyes Julian A , Hanly James 
Published: October 2022

Extremely acidic soils have low pH, high concentration of exchangeable Al<sup>3+</sup> and low cation exchange capacity (CEC) that cause severe growth for most plants. The study was conducted in the soil laboratory of the Indonesian Vegetable Research Institute, Lembang, from June to August 2019. A randomised complete block design with seventeen treatments, three replications, and three incubation times (3, 30 and 60 days) was deployed to assess the effect of rates of soil amendments, namely 5 to 30 t liming materials ha<sup>-1</sup>, 5 to 20 t rice husk biochar ha<sup>-1</sup>, and 5 to 20 t zeolite ha<sup>-1 </sup>on extremely acidic soils. The results showed that lime materials, i.e., lime, agriculture limestone, and hydrated lime had a similar effect on increasing soil pH and reducing exchangeable Al<sup>3+</sup>. Calcium super seemed more effective in increasing soil pH and reducing exchangeable Al<sup>3+</sup> than local lime due to the high CCE value. However, there was no significant response to the highest rice husk biochar and zeolite rate on soil pH and exchangeable Al<sup>3+</sup>. Rice husk biochar increased the concentration of K<sup>+</sup> and zeolite raised the concentration of Na<sup>+</sup>. However, the effect was minimal. About 3 t lime ha<sup>-1</sup> or 2.5 t calcium super ha<sup>-1</sup> or equivalent to 1.5 to 2 times exchangeable Al<sup>3+</sup> is required to obtain the soil pH target of 4.8, where the exchangeable Al<sup>3+</sup> was less than 0.5 cmol<sub>(+)</sub> kg<sup>-1</sup>.
The Clinical Correlations of Fatigue in Patients with Sarcoidosis
Authors: YILDIZ GÜLHAN Pınar , GÜLEÇ BALBAY Ege , ERÇELİK Merve , ANNAKKAYA Ali , ARBAK Peri , ÖZDEMİR KUMBASAR Özlem 
Published: October 2022

Objective: Fatigue is considered a frequent and characteristic feature of sarcoidosis. This
study was designed to determine the prevalence of fatigue in patients with sarcoidosis and
to determine its potential clinical correlations in relation to symptom severity.
Methods: A total of 56 sarcoidosis patients were included. Data on patient demographics,
anthropometrics, disease characteristics, pulmonary function tests, 6-min walking distance
(6MWD), blood biochemistry and hemogram findings were retrieved from hospital records.
Psychometric instruments involved the fatigue assessment scale (FAS), Beck Depression
Inventory (BDI) and Short Form-36 (SF-36) for health-related QOL (HRQOL).
Results: Mean±SD patient age was 50.9±11.9 years. Of 56 patients, 44 were females and
12 were males. When compared to FAS score
Retrospective Analysis of Methyl Alcohol Poisonings Admitted to the Emergency Department
Authors: ŞAHİN Taner , BOL Oğuzhan , ALTUNTAŞ Mükerrem 
Published: October 2022

Objective: Methyl alcohol poisoning remains a significant cause of mortality and morbidity. This poisoning is still one of the important reasons for admission to emergency services. We aimed to examine the admission complaints, laboratory findings, treatment methods, clinical outcomes and examine the factors affecting the mortality of patients diagnosed with methyl alcohol poisoning in the emergency department.
Methods: In this retrospective descriptive study, we analysed the patients who were considered to be diagnosed with methyl alcohol intoxication among those who came to our emergency department due to alcohol intoxication from June 1, 2018 to June 1, 2020.
Results: The study included 20 (4.86%) individuals with methyl alcohol poisoning among 411 people who presented to the emergency department due to ethyl and methyl alcohol intake and resulting effects.The mean age of the patients was 47.35±14.2 years and 85% (n=17/20) were male. Upon reviewing the patients' admission symptoms, 70% were observed to have visual problems, 60% complaints of vomiting, 45% shortness of breath, and 40% changes in consciousness. In the study, it was revealed that 18.2%(n=2/11) females and 81.8%(n=9/11) males died, and the mortality rate was calculated as 55%(n=11/20).
Conclusions: The presence of visual problems, hypotension, and coma in clinical findings, high anion gap metabolic acidosis, marked osmolar gap, an increase in lactate level, and hyperglycemia in laboratory findings may be the early signs of mortality in patients with methyl alcohol poisoning. Therefore, patients with these signs should be followed up more closely and treated.
Effect of Aqueous Extract of Alstonia Boonei on Liver Enzymes and Its Anti-Inflammatory Activity on Formalin- Induced Arthritic Wistar Rats
Authors: Valentine Egho Eseoghene , Oyakhire Mr  Fidelis , Ogie Enehizena Osaro , Obi Harrison Nnamdi , Ochannah Promise Bassey , Asiriuwa Irabonosa , Okafor Chinedu Emmanuel 
Published: October 2022

The anti-inflammatory effect of the aqueous extract of Alstonia boonei on the level of liver biomarker in the plasma of normal and arthritic rats was evaluated using the formalin-induced arthritis inflammation tests. Thirty (30) adult female Wister rats were divided into six groups of five rats each. Group 1 as control, group 2(formalin induced group) while groups 3, 4 and 5 were respectively gavage with 150mg/kg, 300mg/kg and 600mg/kg body weight of the extract daily while group 6 was given reference drug( 5mg/kg body weight of indomethacin for 5 days). After formalin treatment, the paw thickness in formalin-induced group was increased compared with control group. The levels of TNF-alpha, CRP, liver enzymes were increased with severe chronic inflammation sign at histopathologically observation. The animals were sacrificed 24hours after the end of treatments, the skin sample of the right paw was taken for TNF alpha evaluation and blood samples were obtained for assay of the levels of ALT, AST, ALP and C-reactive protein(CRP). Liver enzymes were determined using colorimetric methods while TNFalpha and CRP was determined using ELISA technique. Oral administration of the extract produced significant anti-edematogenic, anti-inflammatory activity and dramatic reduction in liver enzymes, TNF alpha and CRP with a dose of 150mg/kg and 300 mg/kg throughout the period of the experiment. This effect of A.boonei at 300mg/kg was similar to indomethacin group which showed a highly significant (p<0.05) inhibition compared to control group.The result of this study suggests that aqueous extract of A. boonei possesses chronic anti-inflammatory activity which may be mediated by either inhibition or by blocking the release of prostaglandins, histamine and pro-inflammatory cytokine (TNF alpha),which suggest that Alstonia boonei is an alternatve approach for treatment of chronic inflammatory disease, thus supporting its usage for anti- inflammatory treatment and potential effect to resuscitate the hepatocytes.
Pembudayaan Literasi Numerasi dalam Kegiatan Inti Pembelajaran Matematika di Sekolah Menengah Pertama
Authors: Rahmayanti Danica Zerlinda , Sutama  
Published: October 2022

Numerical literacy skills are needed in all aspects of life, both in education, work and society. Numerical literacy continues to grow so that it requires humans to continue to adapt in various aspects of education. Numerical literacy is seen as an evolution and is used as a foundation for the development of education in Indonesia so that the cultivation of numeracy literacy is very important. The research objectives in this article are twofold. 1) Describe controlled training of numeracy literacy culture groups in core activities. 2) Describe the independent training of numeracy literacy culture in core activities. The type of research used by the researcher is qualitative research. This research was carried out on students of SMP Negeri 1 Matesih. The research was conducted from May to September 2022. The research subjects were seventh grade students of SMP Negeri 1 Matesih. Data collection techniques were carried out by collecting documents, collecting theories, interviewing mathematics teachers, direct observation and giving questionnaires. Data validity by triangulation. Data analysis techniques using two ways, namely data reduction, data presentation and conclusions. There are two research results in this article. 1) Controlled training of numeracy literacy culture groups in core activities is carried out with open discussions during mathematics learning. 2) Independent training of numeracy literacy culture in core activities is carried out by giving independent assignments as an exercise. The teacher gives several tasks to support the level of students' understanding of a material.
Estudios STEM y la brecha digital de género en bachillerato
Authors: Hernández Sempere Ismael , Espuny Vidal Cinta 
Published: October 2022

La brecha digital de género es entendida como un aspecto que define la falta de presencia femenina dentro del ámbito de las STEM. Por lo que resulta necesario considerar aspectos como el uso de las TIC o la misma competencia digital para determinar su influencia sobre esta infrarrepresentación.
Este trabajo de investigación ha buscado, por medio de un cuestionario de autoevaluación de la competencia digital -INCOTIC 2.0 (González et al., 2018)-, analizar a un total de 423 estudiantes de segundo de bachillerato de diversas comunidades de toda España. Todo ello, con la finalidad principal de determinar si el nivel de competencia digital es una característica determinante de la falta de presencia de las mujeres en el ámbito STEM.
Finalmente, fruto de los resultados obtenidos, comprobaremos aspectos tan relevantes como el hecho de que un mayor uso TIC no equivale a un mayor nivel de competencia digital, o que las diferencias entre hombres y mujeres con respecto a su nivel de competencia digital y los tipos de estudios cursados -presentes y futuros-, indican que están relacionados y que pueden establecer parte de la brecha existente entre ambos géneros.
Demokrasi dan Media Sosial: Konstelasi Politik dalam Kreasi Meme
Authors: Sofian Akhriyadi 
Published: October 2022

Nowdays digital media especially social media (socmed) has a significant role to disseminate message and information. Socmed with each plattform becomes an effective communication channel through text, video, or picture. And meme is one of the unique communication media in socmed. Creating a meme needs photo or picture which is added short sentence or phrase as a caption to bold the meaning. Multiplication meme in socmed is a must, either duplication or reduplication, therefore very riskful to manipulate information (hoax). Central Java Province have held regional election, and many creation of memes were used by both candidate supporters massively as media campaign to win the election. Many hoax are found in socmed during the election, and also negative and black campaign for sure. This article based on a qualitative research about the meme’s phenomenon of regional election of Central Java Province which was observed in socmed. While discourse theory is used to analyze datas, then we will understand that meme is a visualization of message that has contestation of idea which is argued in virtual space. Sekarang ini media digital khususnya media sosial (medsos) mempunyai peran yang sangat signifikan dalam mendiseminasikan pesan dan informasi. Medsos dengan berbagai platformnya menjadi sebuah saluran komunikasi yang efektif baik itu berupa teks, video, ataupun gambar. Dan meme merupakan salah satu keunikan media komunikasi di medsos. Kreasi meme memerlukan foto ataupun gambar dengan tambahan kalimat pendek atau frasa untuk mempertegas makna. Multiplikasi meme di medsos merupakan suatu keniscayaan, baik berupa duplikasi ataupun reduplikasi, karenanya sangat beresiko untuk memanipulasi informasi (hoax). Pemanfaatan meme secara masif untuk kepentingan politik terlihat pada pemilihan kepala daerah (Pilkada) di Jawa Tengah. Kedua kubu kandidat secara masif memanfaatkan meme sebagai media kampanye untuk memenangkan Pilkada. Berbagai hoax tersebar dalam bentuk meme di medsos selama pergelaran Pilkada: baik itu berupa kampanye negatif maupun kampanye hitam. Artikel ini berbasis pada riset kualitatif mengenai fenomena meme di medsos selama Pilkada Jateng. Teori wacana dipakai oleh peneliti untuk menganalisis data sehingga difahami bahwa meme merupakan visualisasi pesan yang didalamnya mengandung ide yang dikontestasikan di medsos.