bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global regulatory factor AaLaeA upregulates the production of antitumor substances in the endophytic fungus Alternaria alstroemeria
Authors: Yin Xuemin , Han Long , Zheng Wen , Cai Lu , Qin Min , He Zhangjiang , Kang Jichuan 
Published: August 2022

AbstractThe global regulatory factor LaeA has been shown to be involved in the biosynthesis of secondary metabolites in various fungi. In a previous work, we isolated an endophytic fungus from Artemisia annua, and its extract had a significant inhibitory effect on the A549 cancer cell line. Phylogenetic analysis further identified the strain as Alternaria alstroemeria. Overexpression of AalaeA gene resulted in significantly increased antitumor activity of this strain's extract. The 3‐(4, 5‐ dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide assay results showed that the inhibition rate of the AalaeAOE29 mutant extract on A549 cancer cells was significantly higher than that of the WT extract, as the IC50 decreased from 195.0 to 107.4 μg/ml, and the total apoptosis rate was enhanced. Overexpression of the AalaeA gene significantly increased the contents of myricetin, geraniol, ergosterol, and 18 other antitumor compounds as determined by metabolomic analysis. Transcriptomic analysis revealed significant changes in 95 genes in the mutant strain, including polyketide synthases, nonribosomal peptide synthases, cytochrome P450s, glycosyltransferases, acetyl‐CoA acetyltransferases, and others. These results suggested that AaLaeA mediated the antitumor activity of the metabolites in A. alstroemeria by regulating multiple metabolic pathways.
The impact of prior head injury on outcomes following group and individual cognitive processing therapy among military personnel
Authors: Wachen Jennifer Schuster , Mintz Jim , LoSavio Stefanie T. , Kennedy Jan E. , Hale Willie J. , Straud Casey L. , Dondanville Katherine A. , Moring John , Blankenship Abby E. , Vandiver Richard , Young‐McCaughan Stacey , Yarvis Jeffrey S. , Peterson Alan L. , Resick Patricia A. ,   for the STRONG STAR Consortium
Published: August 2022

AbstractThis study examined the impact of a history of head injury (HHI) on posttraumatic stress disorder (PTSD) and depression symptoms in active duty military personnel following group and individual cognitive processing therapy (CPT). Data for these secondary analyses were drawn from a clinical trial comparing group and individual CPT. Service members (N = 268, 91.0% male) were randomized to 12 sessions of group (n = 133) or individual (n = 135) CPT. Most participants (57.1%) endorsed a deployment‐related HHI, 92.8% of whom reported currently experiencing symptoms (CES) related to the head injury (i.e., HHI/CES). Patients classified as non‐HHI/CES demonstrated large, significant improvements in PTSD symptom severity in both individual and group therapy, ds = 1.1, p < .001. Patients with HHI/CES status showed similar significant improvements when randomized to individual CPT, d = 1.4, p < .001, but did not demonstrate significant improvements when randomized to group CPT, d = 0.4, p = .060. For participants classified as HHI/CES, individual CPT was significantly superior to group CPT, d = 0.98, p = .003. Symptoms of depression improved following treatment, with no significant differences by treatment delivery format or HHI/CES status. The findings of this clinical trial subgroup study demonstrate evidence that group CPT is less effective than individual CPT for service members classified as HHI/CES. The results suggest that HHI/CES status may be important to consider in selecting patients for group or individual CPT; additional research is needed to confirm the clinical implications of these findings.
Perioperative pain management based on enhanced recovery after surgery in children undergoing adenotonsillectomy: A prospective, randomized controlled trial
Authors: Yang Yujuan , Cao Jiayu , Chen Xiumei , Liu Dawei , Lv Qiaoying , Ma Jiahai , Zhang Yu , Song Xicheng 
Published: August 2022

AbstractBackgroundPain management, as a key component of enhanced recovery after surgery (ERAS), can effectively relieve perioperative pain and anxiety. However, there are few studies on the application of pain management based on ERAS in pediatric surgery patients. We aimed to examine the effect of ERAS‐based perioperative pain management in children with obstructive sleep apnea (OSA) undergoing adenotonsillectomy.MethodsFrom March 2021 to July 2021, a randomized controlled single‐blind study was conducted on children with OSA and scheduled to undergo adenotonsillectomy. The children were randomly assigned to either control group (n = 60) or ERAS group (n = 60). Traditional analgesia measures were provided to children in the control group, whereas ERAS‐based optimized analgesia measures were provided to children in the ERAS group. The pain scores, anxiety scores and diet quality scores were compared between the two groups.ResultsThe pain scores after surgery in the ERAS group were significantly lower than those in the control group at 6 h, 1 day, 3 days, and 5 days after surgery. Furthermore, the diet quality scores in the ERAS group were significantly higher than those in the control group at 6 h, 1 day, 3 days, and 5 days after surgery. The anxiety scores after surgery in the ERAS group were significantly lower than those in the control group.ConclusionsPerioperative pain management based on ERAS can significantly alleviate postoperative pain, improve quality of life, and promote the accelerated rehabilitation of children with OSA undergoing adenotonsillectomy.Level of evidence1.
Comparison of two multiple plankton samplers: MOCNESS and Multinet Mammoth
Authors: Strand Espen , Broms Cecilie , Bagøien Espen , Knutsen Tor , Arnesen Hilde , Mozfar Bahar 
Published: August 2022

AbstractTo ensure an optimal continuation of a long time series of zooplankton monitoring surveys, two types of equipment for depth‐stratified mesozooplankton sampling were compared. The Institute of Marine Research (Norway) has applied the MOCNESS with good results since 1985, but recent events have made it necessary to change to the Multinet Mammoth. During a cruise in March 2019, both sampling devices were calibrated before 17 paired deployments of the 2 gears were undertaken. During each deployment, three nets and depth‐strata covering ~ 425–200, 200–100, and 100–0 m were sampled. All samples were size‐fractionated or taxonomically fractionated into 10 different biomass categories. The results revealed no significant differences between the two gears when comparing total depth‐integrated biomass (2.46 ± 0.36 vs. 2.61 ± 0.59 gDW m−2) or depth‐integrated biomass of any specific biomass category. Running paired t‐tests separately for all combinations of biomass categories and nets, the differences were only significant for zooplankton biomasses in the 180–1000 μm size fraction and only for Net 2. Possible reasons for this result are discussed in the paper. Gears produced similar catches whether sampling during day or night. We conclude that the MOCNESS and Multinet Mammoth in this study provided comparable results regarding abundances of various zooplankton categories.
Effect of backfilled stone/brine media on the initial electrochemical performance of aluminum sacrificial anode
Authors: Zhao Yongtao , Wang Yanbin , Huang Qingfei , Liu Jian , Wang Hui , Song Shenyou , Qiu Yubing 
Published: August 2022

AbstractAluminum alloy sacrificial anodes applied to protect the subsea immersed tunnels' steel shells are buried in an unfamiliar inhomogeneous backfilled stone/brine media. To verify its influence, the effect of the backfilled stone (10–12, 6–10, and 3–6 mm)/brine (40 Ω cm) media, denoted as Stone 1, Stone 2, and Stone 3, on the initial electrochemical performance of an Al─Zn─In─Si─Sn─Ti anode is investigated by electrochemical and surface analysis techniques. With decreasing the stone size, the Stones 1–3 media's resistivity increases to 100, 125, and 150 Ω cm, respectively. The backfilled stone/brine media inhibits the anode′s free corrosion and pitting process and accelerates its activation in the initial period. The anode′s capacity and current efficiency decrease slightly; however, the anode′s output current and its transmission are depressed more heavily by decreasing the backfilled stone size. Also, the backfilled stone shields parts of the cathode surfaces, decreases dissolved oxygen concentration, and blocks the diffusion of the anode's dissolution product in the media, resulting in the change of the anode's protective effect.
Sweat it for sustainability: Impact of physical activity/exercise on sustainable consumption
Authors: Sarkar Juhi G. , Sarkar Abhigyan , Dwivedi Yogesh K. , Balaji M. S. 
Published: August 2022

AbstractWhat would make the “elusive” green consumer actually choose sustainable products? This research draws from “dopamine hypothesis of reward” to demonstrate that physical activity/exercise (regular and immediate) is a vital factor in determining consumers' sustainable behaviors. More specifically, it examines the role of physical activity/exercise on sustainable consumption behaviors as well as the role of emotional intelligence and sustainability claims. Five studies were conducted to test the hypothesized relationships. The findings from Study 1a and 1b establish direct causal link between physical activity/exercise and customers' sustainable consumption behaviors. Studies 2a and 2b show that emotional intelligence (trait‐based and ability‐based) may explain the effect of physical activity/exercise (regular and immediate) on sustainable consumption behaviors. Finally, the findings from Study 3 demonstrate that sustainability claims moderate the effect of emotional intelligence on sustainable consumption behaviors. These findings offer significant implications for retailers and marketers to use physical activity/exercise as a strategic intervention to positively influence consumers' evaluation and behaviors toward sustainable products.
A standardized ultrasound approach in neuralgic amyotrophy
Authors: Cignetti Natalie E. , Cox Rebecca S. , Baute Vanessa , McGhee Marissa B. , van Alfen Nens , Strakowski Jeffrey A. , Boon Andrea J. , Norbury John W. , Cartwright Michael S. 
Published: August 2022

AbstractNeuralgic amyotrophy (NA), also referred to as idiopathic brachial plexitis and Parsonage‐Turner syndrome, is a peripheral nerve disorder characterized by acute severe shoulder pain followed by progressive upper limb weakness and muscle atrophy. While NA is incompletely understood and often difficult to diagnose, early recognition may prevent unnecessary tests and interventions and, in some situations, allow for prompt treatment, which can potentially minimize adverse long‐term sequalae. High‐resolution ultrasound (HRUS) has become a valuable tool in the diagnosis and evaluation of NA. Pathologic HRUS findings can be grouped into four categories: nerve swelling, swelling with incomplete constriction, swelling with complete constriction, and fascicular entwinement, which may represent a continuum of pathologic processes. Certain ultrasound findings may help predict the likelihood of spontaneous recovery with conservative management versus the need for surgical intervention. We recommend relying heavily on history and physical examination to determine which nerves are clinically affected and should therefore be assessed by HRUS. The nerves most frequently affected by NA are the suprascapular, long thoracic, median and anterior interosseous nerve (AIN) branch, radial and posterior interosseous nerve (PIN) branch, axillary, spinal accessory, and musculocutaneous. When distal upper limb nerves are affected (AIN, PIN, superficial radial nerve), the lesion is almost always located in their respective fascicles within the parent nerve, proximal to its branching point. The purpose of this review is to describe a reproducible, standardized, ultrasonographic approach for evaluating suspected NA, and to share reliable techniques and clinical considerations when imaging commonly affected nerves.
Predictors of improvement in urinary incontinence in the postacute setting: A Canadian cohort study
Authors: Egbujie Bonaventure A. , Northwood Melissa , Turcotte Luke A. , McArthur Caitlin , Berg Katherine , Heckman George A. , Wagg Adrian S. , Hirdes John P. 
Published: August 2022

AbstractPurposeTo determine factors associated with improvement in urinary incontinence (UI) for long‐stay postacute, complex continuing care (CCC) patients.DesignA retrospective cohort investigation of patients in a CCC setting using data obtained from the Canadian Institute for Health Information's Continuing Care Reporting System collected with interRAI Minimum Data Set 2.0.Setting and participantsIndividuals aged 18 years and older, were admitted to CCC hospitals in Ontario, Canada, between 2010 and 2018.MethodsMultivariable logistic regression was used to determine the independent effects of predictors on UI improvement, for patients who were somewhat or completely incontinent on admission and therefore had the potential for improvement.ResultsThe study cohort consisted of 18 584 patients, 74% (13 779) of which were somewhat or completely incontinent upon admission. Among those patients with potential for improvement, receiving bladder training, starting a new medication 90 days prior (odds ratio, OR: 1.54 [95% confidence interval, CI: 1.36–1.75]), and triggering the interRAI Urinary Incontinence Clinical Assessment Protocol to facilitate improvement (OR: 1.36 [95% CI: 1.08–1.71]) or to prevent decline (OR: 1.32 [95% CI: 1.13–1.53]) were the strongest predictors of improvement. Conversely, being totally dependent on others for transfer (OR: 0.62 [95% CI: 0.42–0.92]), is rarely or never understood (OR: 0.65 [95% CI: 0.50–0.85]), having a major comorbidity count of ≥3 (OR: 0.72 [95% CI: 0.59–0.88]), Parkinson's disease, OR: 0.77 (95% CI: 0.62–0.95), Alzheimer/other dementia, OR: 0.83 (95% CI: 0.74–0.93), and respiratory infections, OR: 0.57 (95% CI: 0.39–0.85) independently predicted less likelihood of improvement in UI.Conclusions and ImplicationsFindings of this study suggest that improving physical function, including bed mobility, and providing bladder retraining have strong positive impacts on improvement in UI for postacute care patients. Evidence generated from this study provides useful care planning information for care providers in identifying patients and targeting the care that may lead to better success with the management of UI.
Investigation of the way to enhance the synergistic effect between polyimide and graphene on the tribological performance of polytetrafluoroethylene composites
Authors: Niu Xiaoxing , Zhou Shidong , Pan Deng , Zhao Yuanliang , Li Lei 
Published: August 2022

AbstractIn this article, two different preparation methods were employed to explore the way to maximize the synergistic effect between polyimide (PI) and graphene (Gr) on the friction and wear of polytetrafluoroethylene (PTFE) composites. Results indicate that the incorporation of Gr into PI firstly is more beneficial for the improvement of tribological performance rather than the blending of Gr and PTFE firstly. The incorporation of Gr into PI firstly enhances the wear resistance of PI/Gr phases. Gr fillers is not taken away easily by the plastic flow of PTFE resin and Gr will accumulate on the wear surface of PI/Gr. The synergistic effect of PI and Gr will play a better role in the friction and wear of PTFE/PI/Gr. However, the wear performance of PI phases cannot be enhanced effectively by the blending of Gr and PTFE firstly. And Gr will be taken away by the severe wear of PTFE phases in PTFE/Gr/PI. Only tiny Gr accumulates on the wear surface of PI phases, the synergistic effect of PI and Gr will not play a better role in friction and wear.
Respiratory muscle fatigability in patients with spinal muscular atrophy
Authors: Kant‐Smits Kim , Hulzebos Erik H. J. , Habets Laura E. , Asselman Fay‐Lynn , Veldhoen Esther S. , van Eijk Ruben P. A. , de Groot Janke F. , van der Pol W. Ludo , Bartels Bart 
Published: August 2022

AbstractBackgroundRespiratory failure is a major cause of morbidity and mortality in patients with Spinal Muscular Atrophy (SMA). Lack of endurance, or “fatigability,” is an important symptom of SMA. In addition to respiratory muscle weakness, respiratory function in SMA may be affected by Respiratory Muscle Fatigability (RMF).AimThe purpose of this study was to explore RMF in patients with SMA.MethodsWe assessed a Respiratory Endurance Test (RET) in 19 children (median age [years]: 11) and 36 adults (median age [years]: 34) with SMA types 2 and 3. Participants were instructed to breath against an inspiratory threshold load at either 20%, 35%, 45%, 55%, or 70% of their individual maximal inspiratory mouth pressure (PImax). RMF was defined as the inability to complete 60 consecutive breaths. Respiratory fatigability response was determined by change in maximal inspiratory mouth pressure (ΔPImax) and perceived fatigue (∆perceived fatigue).ResultsThe probability of RMF during the RET increased by 59%−69% over 60 breaths with every 10% increase in inspiratory threshold load (%PImax). Fatigability response was characterized by a large variability in ΔPImax (−21% to +16%) and a small increase in perceived fatigue (p = 0.041, range 0 to +3).Conclusion and Key FindingsPatients with SMA demonstrate a dose‐dependent increase in RMF without severe increase in exercise‐induced muscle weakness or perceived fatigue. Inspiratory muscle loading in patients with SMA seems feasible and its potential to stabilize or improve respiratory function in patients with SMA needs to be determined in further research.
The therapeutic potential of berberine chloride against SARM1‐dependent axon degeneration in acrylamide‐induced neuropathy
Authors: Wang Shuai , Zhang Yifan , Lou Jianwei , Yong Hui , Shan Shulin , Liu Zhidan , Song Mingxue , Zhang Cuiqin , Kou Ruirui , Liu Zhaoxiong , Yu Wenhao , Zhao Xiulan , Song Fuyong 
Published: August 2022

AbstractChronic acrylamide (ACR) intoxication causes typical pathology of axon degeneration. Moreover, sterile‐α and toll/interleukin 1 receptor motif‐containing protein 1 (SARM1), the central executioner of the programmed axonal destruction process under various insults, is up‐regulated in ACR neuropathy. However, it remains unclear whether inhibitors targeting SARM1 are effective or not. Among all the pharmacological antagonists, berberine chloride (BBE), a natural phytochemical and the first identified non‐competitive inhibitor of SARM1, attracts tremendous attention. Here, we observed the protection of 100 μM BBE against ACR‐induced neurites injury (2 mM ACR, 24 hr) in vitro, and further evaluated the neuroprotective effect of BBE (100 mg/kg p.o. three times a week for 4 weeks) in ACR‐intoxicated rats (40 mg/kg i.p. three times a week for 4 weeks). The expression of SARM1 was also detected. BBE intervention significantly inhibited the overexpression of SARM1, ameliorated axonal degeneration, alleviated pathological changes in the sciatic nerve and spinal cord, and improved neurobehavioral symptoms in ACR‐poisoned rats. Thus, BBE exhibits a strong neuroprotective effect against the SARM1‐dependent axon destruction in ACR neuropathy. Meanwhile, our study underscores the need for appropriate inhibitor selection in diverse situations that would benefit from blocking the SARM1‐dependent axonal destruction pathway.
Fast and Robust Multiqubit Gates on Rydberg Atoms by Periodic Pulse Engineering
Authors: Wu Jin‐Lei , Wang Yan , Han Jin‐Xuan , Su Shi‐Lei , Xia Yan , Song Jie , Jiang Yongyuan 
Published: August 2022

AbstractThe idea of periodic pulse engineering (PPE) is exploited to achieve unconventional Rydberg pumping for a robust multiqubit gate on Rydberg atoms trapped in a 2D array. By designing component parameters in PPE, fast regimes of full and partial Rydberg antiblockade (RAB) among three atoms are explored. Furthermore, through assigning appropriate components in PPE a phenomenon of RAB‐based blockade emerges and then a three‐qubit gate can be achieved. It is identified that two kinds of Rydberg–Rydberg interaction (RRI), van der Waals interaction and dipole–dipole Förster resonance interaction, are both applicative for implementing the proposed scheme. Different from recent schemes of Rydberg atom multiqubit gates, the operated atoms are indistinguishable with respect to the laser field of PPE, and the present one‐step scheme is essentially fast owing to the first‐order dynamics where the dominant component in PPE is not degraded. In addition, the proposed multiqubit gate is robust against atomic decay and deviation of RRI strengths, because the excitation duration of atoms is short, with the total excitation number ⩽1. This work may facilitate experimental demonstration of RAB‐based gates of strongly coupled atoms.
Nonlinear model predictive control of a radiative heating process with movable radiators
Authors: Rötzer Florian , Dörschel Lorenz , Deutschmann‐Olek Andreas , Abel Dirk , Kugi Andreas 
Published: August 2022

AbstractA nonlinear model predictive control concept for a heating process with dominant radiation and movable radiators is derived. Such processes can be described by a nonlinear integro‐partial differential equation with full domain coupling for the thermal subsystem and an ordinary differential equation for the mechanical subsystem. For model‐based control, a reduced‐order model based on a tailored proper orthogonal decomposition Galerkin approach is used. To enable real‐time capability, a rigorous formulation of the optimization problem is presented, which allows to split the optimization problem into two subproblems using a separation of time scales. These subproblems are subsequently simplified by employing averaging methods and appropriate analytical solutions. An extensive simulation study illustrates the high performance and fast calculation times of the proposed control concept.
Integrating two‐dimensional water temperature simulations into a fish habitat model to improve hydro‐ and thermopeaking impact assessment
Authors: Antonetti Manuel , Hoppler Luca , Tonolla Diego , Vanzo Davide , Schmid Martin , Doering Michael 
Published: August 2022

AbstractStorage hydropower plants, which are an important component of energy production in Switzerland, can lead to hydro‐ and thermopeaking, affecting river habitats and organisms. In this study, we developed an approach for integrating water temperature simulations into a habitat model to assess the impact of both hydro‐ and thermopeaking on the availability of suitable fish habitats. We focused on the habitat requirements of juvenile brown trout (Salmo trutta) in a semi‐natural braided floodplain along the Moesa River (Southern Switzerland) in early summer. First, we defined different scenarios (with and without hydropeaking) based on the local hydrological and meteorological conditions. Second, we used a two‐dimensional depth‐averaged hydro‐ and thermodynamic model to simulate the spatial distributions of water depth, flow velocity, and water temperature. Third, we applied generalized preference curves for juvenile brown trout to identify hydraulically suitable habitats, and developed a new index to assess the availability of thermally suitable habitats. Finally, we quantified the extent to which hydraulically and thermally suitable habitats overlap in space and time. During both base and peak flow phases, most of the hydraulically and thermally suitable habitats are located in the side channels. High flow conditions combined with strong cold‐thermopeaking lead to a higher thermal heterogeneity. However, disconnected habitats originate in the dewatering zone, increasing the risk of stranding as well as thermal stress. By helping to better understand the effects of thermopeaking on the availability of fish habitats, our approach could contribute to the design and evaluation of ecological restoration in hydropeaking rivers.