bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collective Bargaining Retrenchment in Union Country: The Politics of 2011 Wisconsin's “Budget Repair” Bill
Authors: Oszkay Yotala 
Published: December 2022

AbstractIn 2011, the passage of Governor Scott Walker's “Budget Repair” policy retrenched collective bargaining rights for public workers in Wisconsin, a state that was the earliest adopter of these rights and locally celebrated as “union country.” In this article, I use critical juncture analysis to examine this significant case of institutional change. I argue that newly elected GOP politicians initially saw opportunity in a new legislative majority—emerging from the popularity of the Tea Party during the 2010 midterm elections—and attempted strategic policy crafting to mobilize support for this anti-union bill. However, these efforts eventually devolved into a reactive struggle for power with entrenched Democratic legislators and previous policy beneficiaries. Incorporating work on organizational deviance, I show how politicians in both parties sought to control the policymaking process with improvised oppositional tactics that undermined governing norms, ultimately resulting in the bill's passage. This study, thus, expands on theories of institutional change, illuminating the subversive politics of many contemporary movements and political parties.
Successful completion of treadmill testing provides relief and reassurance for children with non-specific chest pain
Authors: Turkyilmaz Irem , Ates Burcin Ozlem , Congologlu Mehmet Ayhan , Kilic Ayhan 
Published: December 2022

AbstractObjective:Non-specific chest pain is one of the leading causes of admissions in paediatric cardiology outpatient clinics, and its management usually consists of extensive reassurance of patients and their families. As we have often observed that successful completion of treadmill testing during diagnostic work-up provides relief and reassurance in these patients and their families, we planned this study to quantitatively assess anxiety levels and perception of illness among children with non-specific chest pain before and after treadmill testing.Method:We studied 50 children (aged 11.8 ± 3.0 years, range 7–17 years; 24 females, 26 males) with a chief complaint of non-specific chest pain and negative history and echocardiography. They were asked to fill the Revised Children’s Anxiety and Depression Scale before the treadmill testing and 1–10 days after successful completion of treadmill testing.Results:Average total anxiety scores (36.38 ± 19.09 versus 33.36 ± 19.09, respectively) and average of total anxiety + depression scores (44.3 ± 24.92 versus 40.8 ± 26.97, respectively) of the children were found to be significantly lower after negative treadmill testing as compared to scores before testing (p < 0.05). Alterations in separation anxiety, panic, social phobia, obsession-compulsion scores were not statistically significant (p > 0.05).Conclusion:Children with non-specific chest pain feel relieved and reassured after successful completion of treadmill testing. To the best of our knowledge, our study is the first in the literature to show this relationship quantitatively.
Pediatric Casualties in Terrorist Attacks: A Semi-Quantitative Analysis of Global Events
Authors: Ohana Sarna Cahan Lea , Tin Derrick , Markovic Vesna , Ciottone Robert G. , Issa Fadi , Kane Ashley E. D. , Hart Alexander , Weiner Debra L. , Ciottone Gregory R. 
Published: December 2022

AbstractBackground:Terrorism remains a major threat and concern in many countries around the world. Pediatric populations represent approximately 30% of the world population, and in the event of a terrorist attack, can either be primary targets, to include the possibility of abduction, or unintended victims. They are unique in their vulnerabilities and, therefore, require special consideration.Methods:This study is a semi-quantitative, epidemiological analysis of all terrorism-related pediatric fatalities and injuries sustained from 1970-2019. Data collection was performed using a retrospective database search through the Global Terrorism Database (GTD). Summaries of events including search terms associated with pediatric population were individually reviewed and those describing the deaths, injuries, or abductions were tallied.Results:Of the over 200,000 terror events, 2,302 events met inclusion criteria. This represented 1.14% of total events which involved death, injury, or abduction. Of 2,032 events, a total of 2,275 pediatric fatal injuries (FI) were recorded, as well as 2,280 pediatric non-fatal injuries (NFI). The most common weapons used in all attacks involving the pediatric population were explosives (1,539 [66.8%]), firearms (543 [23.5%]), other (169 [7.3%]), and melee (83 [3.6%]). A total of 275 of the 2,032 events were related to abductions, with 71 cases involving the abduction of 10 individuals or more.Conclusion:Pediatric casualties in terrorist events represent a small proportion of overall victims. However, it should be understood that the pediatric population has unique vulnerabilities, and when directly impacted by terrorism, can have long-term physical and psychosocial sequelae, as well as a devastating emotional impact on the community.
Palliative care physicians’ decision-making about palliative sedation for existential suffering: A Belgian nationwide qualitative study
Authors: Rodrigues Paulo , Ostyn Jozefien , Mroz Sarah , Ronse Axelle , Menten Johan , Gastmans Chris 
Published: December 2022

AbstractObjectivesThis study aims to provide an in-depth understanding of the content and process of decision-making about palliative sedation for existential suffering (PS-ES) as perceived by Belgian palliative care physicians.MethodsThis Belgian nationwide qualitative study follows a grounded theory approach. We conducted semistructured interviews with 25 palliative care physicians working in 19 Belgian hospital-based palliative care units and 4 stand-alone hospices. We analyzed the data using the Qualitative Analysis Guide of Leuven, and we followed the Consolidated Criteria for Reporting Qualitative Research Guidelines (COREQ).ResultsAnalysis of the data identified several criteria that physicians apply in their decision-making about PS-ES, namely, the importance of the patient’s demand, PS-ES as a last resort option after all alternatives have been applied, the condition of unbearable suffering combined with other kinds of suffering, and the condition of being in a terminal stage. Regarding the process of decision-making itself, physicians refer to the need for multidisciplinary perspectives supported by an interpretative dialogue with the patient and all other stakeholders. The decision-making process involves a specific temporality and physicians’ inner conviction about the need of PS-ES.Significance of resultsBelgian palliative care physicians are not sure about the criteria regarding decision-making in PS-ES. To deal with complex existential suffering in end-of-life situations, they stress the importance of participation by all stakeholders (patient, relatives, palliative care team, other physicians, nurses, social workers, physiotherapists, occupational therapists, chaplains, etc.) in the decision-making process to prevent inadequate decisions being made.
Revised Beckian cognitive therapy for generalised anxiety disorder
Authors: Gústavsson Sævar M. , Salkovskis Paul M. , Sigurðsson Jón F. 
Published: December 2022

Abstract
Since its inclusion in the DSM-III, various theories and treatment approaches have been developed for generalised anxiety disorder (GAD). Aaron T. Beck was the first to offer a cognitive conceptualisation of GAD in Anxiety Disorders and Phobias: A Cognitive Perspective. This original cognitive model of GAD was initially found to be promising in treating GAD but has not been developed further. Other theoretical models and treatments of GAD have gained more research attention, such as the Intolerance of Uncertainty model and Meta-Cognitive model. This article offers a brief overview of multiple theories and treatment approaches of GAD followed by an extensive discussion about the original cognitive model and a revised cognitive model of GAD in the Beckian tradition. Specifically, this paper describes how known key psychological maintenance factors of anxiety disorders, i.e. threat beliefs, safety-seeking behaviours and selective attention, can be used to conceptualise the experience of people with GAD and guide treatment. This is done with theoretical discussion as well as clinical examples. Finally, the paper offers suggestions for key ingredients to be included in cognitive therapy for GAD and future directions for research.

Key learning aims

(1)
To understand the clinical implications of the original cognitive model and the revised model of generalised anxiety disorder presented here.

(2)
To understand the role of inflated responsibility for safety, safety-seeking behaviours and elevated evidence requirements in generalised anxiety disorder.

(3)
To understand and be able to implement treatment recommendations of the revised cognitive model of generalised anxiety disorder.
UVA induces retinal photoreceptor cell death via receptor interacting protein 3 kinase mediated necroptosis
Authors: Yu Zhen , Correa Victor S. M. C. , Efstathiou Nikolaos E. , Albertos-Arranz Henar , Chen Xiaohong , Ishihara Kenji , Iesato Yasuhiro , Narimatsu Toshio , Ntentakis Dimitrios , Vavvas Demetrios G. 
Published: December 2022

AbstractUltraviolet light A (UVA) is the only UV light that reaches the retina and can cause indirect damage to DNA via absorption of photons by non-DNA chromophores. Previous studies demonstrate that UVA generates reactive oxygen species (ROS) and leads to programmed cell death. Programmed cell death (PCD) has been implicated in numerous ophthalmologic diseases. Here, we investigated receptor interacting protein 1 and 3 (RIPK1 and RIPK3) kinases, key signaling molecules of PCD, in UVA-induced photoreceptor injury using in vitro and ex vivo models. UVA irradiation activated RIPK3 but not RIPK1 and mediated necroptosis through MLKL that lie downstream of RIPK3 and induced apoptosis through increased oxidative stress. Moreover, RIPK3 but not RIPK1 inhibition suppresses UVA-induced cell death along with the downregulation of MLKL and attenuates the levels of oxidative stress and DNA fragmentation. In conclusion, these results identify RIPK3, not RIPK1, as a critical regulator of UVA-induced necroptosis cell death in photoreceptors and highlight RIPK3 potential as a neuroprotective target.
Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America
Authors: Zamudio Roxana , Boerlin Patrick , Beyrouthy Racha , Madec Jean-Yves , Schwarz Stefan , Mulvey Michael R. , Zhanel George G. , Cormier Ashley , Chalmers Gabhan , Bonnet Richard , Haenni Marisa , Eichhorn Inga , Kaspar Heike , Garcia-Fierro Raquel , Wood James L. N. , Mather Alison E. 
Published: December 2022

AbstractExtended-spectrum cephalosporins (ESCs) are critically important antimicrobial agents for human and veterinary medicine. ESC resistance (ESC-R) genes have spread worldwide through plasmids and clonal expansion, yet the distribution and dynamics of ESC-R genes in different ecological compartments are poorly understood. Here we use whole genome sequence data of Enterobacterales isolates of human and animal origin from Europe and North America and identify contrasting temporal dynamics. AmpC β-lactamases were initially more dominant in North America in humans and farm animals, only later emerging in Europe. In contrast, specific extended-spectrum β-lactamases (ESBLs) were initially common in animals from Europe and later emerged in North America. This study identifies differences in the relative importance of plasmids and clonal expansion across different compartments for the spread of different ESC-R genes. Understanding the mechanisms of transmission will be critical in the design of interventions to reduce the spread of antimicrobial resistance.
An atlas of late prenatal human neurodevelopment resolved by single-nucleus transcriptomics
Authors: Ramos Susana I. , Mussa Zarmeen M. , Falk Elisa N. , Pai Balagopal , Giotti Bruno , Allette Kimaada , Cai Peiwen , Dekio Fumiko , Sebra Robert , Beaumont Kristin G. , Tsankov Alexander M. , Tsankova Nadejda M. 
Published: December 2022

AbstractLate prenatal development of the human neocortex encompasses a critical period of gliogenesis and cortical expansion. However, systematic single-cell analyses to resolve cellular diversity and gliogenic lineages of the third trimester are lacking. Here, we present a comprehensive single-nucleus RNA sequencing atlas of over 200,000 nuclei derived from the proliferative germinal matrix and laminating cortical plate of 15 prenatal, non-pathological postmortem samples from 17 to 41 gestational weeks, and 3 adult controls. This dataset captures prenatal gliogenesis with high temporal resolution and is provided as a resource for further interrogation. Our computational analysis resolves greater complexity of glial progenitors, including transient glial intermediate progenitor cell (gIPC) and nascent astrocyte populations in the third trimester of human gestation. We use lineage trajectory and RNA velocity inference to further characterize specific gIPC subpopulations preceding both oligodendrocyte (gIPC-O) and astrocyte (gIPC-A) lineage differentiation. We infer unique transcriptional drivers and biological pathways associated with each developmental state, validate gIPC-A and gIPC-O presence within the human germinal matrix and cortical plate in situ, and demonstrate gIPC states being recapitulated across adult and pediatric glioblastoma tumors.
Plasmonic gain in current biased tilted Dirac nodes
Authors: Park Sang Hyun , Sammon Michael , Mele Eugene , Low Tony 
Published: December 2022

AbstractSurface plasmons, which allow tight confinement of light, suffer from high intrinsic electronic losses. It has been shown that stimulated emission from excited electrons can transfer energy to plasmons and compensate for the high intrinsic losses. To-date, these realizations have relied on introducing an external gain media coupled to the surface plasmon. Here, we propose that plasmons in two-dimensional materials with closely located electron and hole Fermi pockets can be amplified, when an electrical current bias is applied along the displaced electron-hole pockets, without the need for an external gain media. As a prototypical example, we consider WTe2 from the family of 1T$${}^{{\prime} }$$

′

-MX2 materials, whose electronic structure can be described within a type-II tilted massive Dirac model. We find that the nonlocal plasmonic response experiences prominent gain for experimentally accessible currents on the order of mAμm−1. Furthermore, the group velocity of the plasmon found from the isofrequency curves imply that the amplified plasmons are highly collimated along a direction perpendicular to the Dirac node tilt when the electrical current is applied along it.
Ultra-low loss quantum photonic circuits integrated with single quantum emitters
Authors: Chanana Ashish , Larocque Hugo , Moreira Renan , Carolan Jacques , Guha Biswarup , Melo Emerson G. , Anant Vikas , Song Jindong , Englund Dirk , Blumenthal Daniel J. , Srinivasan Kartik , Davanco Marcelo 
Published: December 2022

AbstractThe scaling of many photonic quantum information processing systems is ultimately limited by the flux of quantum light throughout an integrated photonic circuit. Source brightness and waveguide loss set basic limits on the on-chip photon flux. While substantial progress has been made, separately, towards ultra-low loss chip-scale photonic circuits and high brightness single-photon sources, integration of these technologies has remained elusive. Here, we report the integration of a quantum emitter single-photon source with a wafer-scale, ultra-low loss silicon nitride photonic circuit. We demonstrate triggered and pure single-photon emission into a Si3N4 photonic circuit with ≈ 1 dB/m propagation loss at a wavelength of ≈ 930 nm. We also observe resonance fluorescence in the strong drive regime, showing promise towards coherent control of quantum emitters. These results are a step forward towards scaled chip-integrated photonic quantum information systems in which storing, time-demultiplexing or buffering of deterministically generated single-photons is critical.
Potassium isotope heterogeneity in the early Solar System controlled by extensive evaporation and partial recondensation
Authors: Hu Yan , Moynier Frédéric , Bizzarro Martin 
Published: December 2022

AbstractVolatiles are vital ingredients for a habitable planet. Angrite meteorites sample the most volatile-depleted planetesimal in the Solar System, particularly for the alkali elements. They are prime targets for investigating the formation of volatile-poor rocky planets, yet their exceptionally low volatile content presents a major analytical challenge. Here, we leverage improved sensitivity and precision of K isotopic analysis to constrain the mechanism of extreme K depletion (>99.8%) in angrites. In contrast with the isotopically heavy Moon and Vesta, we find that angrites are strikingly depleted in the heavier K isotopes, which is best explained by partial recondensation of vaporized K following extensive evaporation on the angrite parent body (APB) during magma-ocean stage. Therefore, the APB may provide a rare example of isotope fractionation controlled by condensation, rather than evaporation, at a planetary scale. Furthermore, nebula-wide K isotopic variations primarily reflect volatility-driven fractionations instead of presolar nucleosynthetic heterogeneity proposed previously.
Microwave imaging of quasi-periodic pulsations at flare current sheet
Authors: Kou Yuankun , Cheng Xin , Wang Yulei , Yu Sijie , Chen Bin , Kontar Eduard P. , Ding Mingde 
Published: December 2022

AbstractQuasi-periodic pulsations (QPPs) are frequently detected in solar and stellar flares, but the underlying physical mechanisms are still to be ascertained. Here, we show microwave QPPs during a solar flare originating from quasi-periodic magnetic reconnection at the flare current sheet. They appear as two vertically detached but closely related sources with the brighter ones located at flare loops and the weaker ones along the stretched current sheet. Although the brightness temperatures of the two microwave sources differ greatly, they vary in phase with periods of about 10–20 s and 30–60 s. The gyrosynchrotron-dominated microwave spectra also present a quasi-periodic soft-hard-soft evolution. These results suggest that relevant high-energy electrons are accelerated by quasi-periodic reconnection, likely arising from the modulation of magnetic islands within the current sheet as validated by a 2.5-dimensional magnetohydrodynamic simulation.
Features derived from blood pressure and intracranial pressure predict elevated intracranial pressure events in critically ill children
Authors: Ackerman Kassi , Mohammed Akram , Chinthala Lokesh , Davis Robert L. , Kamaleswaran Rishikesan , Shafi Nadeem I. 
Published: December 2022

AbstractClinicians frequently observe hemodynamic changes preceding elevated intracranial pressure events. We employed a machine learning approach to identify novel and differentially expressed features associated with elevated intracranial pressure events in children with severe brain injuries. Statistical features from physiologic data streams were derived from non-overlapping 30-min analysis windows prior to 21 elevated intracranial pressure events; 200 records without elevated intracranial pressure events were used as controls. Ten Monte Carlo simulations with training/testing splits provided performance benchmarks for 4 machine learning approaches. XGBoost yielded the best performing predictive models. Shapley Additive Explanations analyses demonstrated that a majority of the top 20 contributing features consistently derived from blood pressure data streams up to 240 min prior to elevated intracranial events. The best performing prediction model was using the 30–60 min analysis window; for this model, the area under the receiver operating characteristic window using XGBoost was 0.82 (95% CI 0.81–0.83); the area under the precision-recall curve was 0.24 (95% CI 0.23–0.25), above the expected baseline of 0.1. We conclude that physiomarkers discernable by machine learning are concentrated within blood pressure and intracranial pressure data up to 4 h prior to elevated intracranial pressure events.
Disruption of male fertility-critical Dcaf17 dysregulates mouse testis transcriptome
Authors: Abu-Dawud Raed , Mistry Bhavesh V. , Rajab Mohamed , Alanazi Maha , Al-Yacoub Nadya , Kashir Junaid , Almohanna Falah , Colak Dilek , Assiri Abdullah M. 
Published: December 2022

AbstractDuring mammalian spermatogenesis, the ubiquitin proteasome system maintains protein homoeostasis (proteastasis) and spermatogenic cellular functions. DCAF17 is a substrate receptor in the ubiquitin CRL4 E3 Ligase complex, absence of which causes oligoasthenoteratozoospermia in mice resulting in male infertility. To determine the molecular phenomenon underlying the infertility phenotype caused by disrupting Dcaf17, we performed RNA-sequencing-based gene expression profiling of 3-weeks and 8-weeks old Dcaf17 wild type and Dcaf17 disrupted mutant mice testes. At three weeks, 44% and 56% differentially expressed genes (DEGs) were up- and down-regulated, respectively, with 32% and 68% DEGs were up- and down-regulated, respectively at 8 weeks. DEGs include protein coding genes and lncRNAs distributed across all autosomes and the X chromosome. Gene ontology analysis revealed major biological processes including proteolysis, regulation of transcription and chromatin remodelling are affected due to Dcaf17 disruption. We found that Dcaf17 disruption up-regulated several somatic genes, while germline-associated genes were down-regulated. Up to 10% of upregulated, and 12% of downregulated, genes were implicated in male reproductive phenotypes. Moreover, a large proportion of the up-regulated genes were highly expressed in spermatogonia and spermatocytes, while the majority of downregulated genes were predominantly expressed in round spermatids. Collectively, these data show that the Dcaf17 disruption affects directly or indirectly testicular proteastasis and transcriptional signature in mouse.
Efficient cross-validation traversals in feature subset selection
Authors: Lausser Ludwig , Szekely Robin , Schmid Florian , Maucher Markus , Kestler Hans A. 
Published: December 2022

AbstractSparse and robust classification models have the potential for revealing common predictive patterns that not only allow for categorizing objects into classes but also for generating mechanistic hypotheses. Identifying a small and informative subset of features is their main ingredient. However, the exponential search space of feature subsets and the heuristic nature of selection algorithms limit the coverage of these analyses, even for low-dimensional datasets. We present methods for reducing the computational complexity of feature selection criteria allowing for higher efficiency and coverage of screenings. We achieve this by reducing the preparation costs of high-dimensional subsets$${\mathscr {O}}({n}m^2)$$O(nm2)to those of one-dimensional ones$${\mathscr {O}}(m^2)$$O(m2). Our methods are based on a tight interaction between a parallelizable cross-validation traversal strategy and distance-based classification algorithms and can be used with any product distance or kernel. We evaluate the traversal strategy exemplarily in exhaustive feature subset selection experiments (perfect coverage). Its runtime, fitness landscape, and predictive performance are analyzed on publicly available datasets. Even in low-dimensional settings, we achieve approximately a 15-fold increase in exhaustively generating distance matrices for feature combinations bringing a new level of evaluations into reach.