bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical Aspects for Evaluation of Pharmaceutical Products: A Mini- Review
Authors: Kogawa Ana Carolina , Lustosa Isadora Alves , de Souza Gil Eric 
Published: September 2022

Background:The pharmaceutical industry is in constant development, aiming to increase its portfolio, optimizing time, product quality and efficacy along with patient safety. The main goal of developing and validating an analytical method is to achieve a balance between costs and risks within the wide array of technical possibilities in order to assure that the method is capable of meeting its expectations, ensuring effective quality control.Objective:The objective of this mini-review is to discuss the analytical aspects of development and validation for analysis of pharmaceutical products, focusing on the complete evaluation package in a systematic way to demonstrate the optimal performance of the method.Methods/Results:Validation results are obtained following strict protocols, typically starting with the assessment of selectivity/specificity parameters, followed by parameters such as linearity and precision. Moreover, accuracy, detection limit, quantification limit and method robustness are also evaluated.Conclusion:This paper may serve as a guide for the pharmaceutical-chemical laboratory, conceptualizing quality and current analytical needs, according to Green Analytical Chemistry, for the development and validation of reliable methods, ensuring clarity to the analyst and assisting in decision making.
Unravelling the Influence of Nutrition and Mental Stress on Immune
Response
Authors: Mishra Rashmi , Pandey Pratibha , Khan Fahad 
Published: September 2022

Abstract:
The review reveals the role of mental as well as biological phenomena working behind
immunity. In recent times, irresistible illnesses and inflammation have been thought to be hereditary
or the result of the natural working mechanism of the human body in response to the pathogenic
variables working inside the human system. In the past few years, the importance of psychological
adjustments, mental well-being and eating habits has been studied and shown to have a marked
effect on immunity. Psychoneuroimmunology considers that mental disorders are strongly interrelated
with the resistant reaction. Besides, the immunological components control the well-being of
the individual. Psychosocial mediations help reduce disease severity and enhance the functioning
of the immune system. Nutrition plays a vital role in immunity and thus has an influence on our
mental health.
Sericic Acid Ameliorates DSS-induced Ulcerative Colitis in Mice by Modulating
the NF-κB and Nrf2 Pathways
Authors: Liu Dailin , Lifei-Luo  , Zhang Jingze , Li Xinyu , Zhu Yanru , Wang Yansheng 
Published: September 2022

Background:
Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease. In previous studies, we found extracts from the roots of Rosa odorata Sweet var. gigantea (Coll.et Hemsl.) Rehd. et Wils have a therapeutic effect on UC. Furthermore, sericic acid (SA) is a pentacyclic triterpenoid isolated from this plant that is being used for the first time. The purpose of this study was to investigate whether SA has anti-inflammatory and therapeutic effects on UC and its underlying mechanisms.

Methods:
In this study, we used a dextran sulfate-induced UC mouse model and lipopolysaccharide (LPS)-induced inflammatory cell model along with an enzyme-linked immunosorbent assay(ELISA) to quantify the abundance of inflammatory factors and oxidative stress factors in tissues and cells. HE staining was used to analyze the therapeutic effect of the drugs on the UC mouse model. The expression levels of oxidative stress-related proteins were detected using immunoblotting and immunohistochemistry. The anti-inflammatory targets of SA were screened using protein chip arrays and verified by immunoblotting.

Results:
We found that SA had anti-inflammatory and antioxidant effects in animal and cellular inflammation models. SA inhibited the levels of NO, TNF-α, IL-6, IL-1β, and MDA in tissues and cells and upregulated the expression level of SOD. Animal experiments showed that SA alleviated the shortening of colon length and colon pathological damage caused by DSS. The anti-inflammatory targets of SA were screened using protein chip arrays, and SA was found to inhibit proteins related to the NF-κB signaling pathway. Finally, immunoblotting and immunohistochemistry showed that SA downregulated the expression of p-IKKα/β and its downstream protein p-NF-κB, while promoting the expression of Nrf2 and its downstream protein HO-1.

Conclusion:
The above results indicated that SA alleviated DSS-induced colitis by inhibiting NF-κB signaling pathway and activating Nrf2 pathway.
Antiparkinsonian Potential of Natural Products: Molecular Docking,
Prediction of Pharmacokinetic and Toxicological Properties
Authors: Lima Henrique B. , Ferreira Jaderson V. , Nery Mariela L. , Chaves Gisele A. , da Costa Anderson L. P. , de Souza Lucilene R. , Marino Bianca L. , Brito Maiara F.B. , Teixeira Hueldem R.C. , Silva Carlos H.T.P. , Taft Carlton A. , Hage-Melim Lorane I.S. 
Published: September 2022

Background:
Parkinson's disease (PD) is a neurodegenerative pathology common in the elderly, and it may be related to several factors, such as excessive and continuous use of drugs, alcoholism, cerebral ischemia, among others. Emphasizing that there is still no cure for PD, current pharmacological treatment aims to restore reduced dopaminergic activity in the central nervous system and manage symptoms. However, due to the different side effects caused by antiparkinsonian drugs, their use is recommended just when symptoms are considerably impairing professional performance or the patient's daily tasks. Therefore, studies for the development of new drugs have been conducted, and natural products are gaining importance due to the possibility of discovering new bioactive molecular. In this sense, this research aimed to perform the in silico study of molecules of natural origin for the treatment of PD.

Methods:
A search for molecules from medicinal plants was carried out, they underwent a pharmacokinetic and toxicological prediction with subsequent molecular docking study, being coupled with the MAO-B enzyme and the dopamine receptor 2.

Results:
The ginsenosides compounds present an unfavorable pharmacokinetic pattern, which can be explained by their molecular mass, while the other molecules present average patterns, with the exception of kavains, which obtained very satisfactory results. When it comes to toxicity, the molecules curcumin, dihydrokavain, vitexin, kavain and tetrahydrocurcumin did not exhibit any toxic alert. As for the molecular docking study, the compound curcumin stood out with a considerable number of interactions at many amino acid residues relevant to antiparkinsonian activity, both in the MAO-B enzyme and in the D2 receptor.

Conclusion:
Of 25 molecules of natural products, 3 are good candidates for studies of oral drugs, owing to their excellent pharmacokinetic profile and low probability of being toxic. The curcumin molecule has a great notoriety, as it obtained relevant interactions with the two proteins studied in molecular docking, speciallyin the MAO-B enzyme.
An Overview of Paclitaxel and Molecular Imprinted Polymers Capped with Quantum Dots as an Alternative Approach for Paclitaxel Extraction and Detection
Authors: Malik Azad Qayoom , Mir Tahir ul Gani , Kumar Deepak 
Published: September 2022

Abstract:Paclitaxel (Taxol) is a drug that belongs to the class of compounds called Taxane. It is a strong and potent chemotherapeutic drug that inhibits the growth of certain types of cancer cells; however, its abundance is very low, and various types of methodologies have been implemented to extract paclitaxel from the bark of different plants and herbs. The molecularly imprinted polymers (MIPs) could be the best alternative to purify the paclitaxel molecule. MIPs have become an attractive solution for the selective and fine-tuned determination of target templates in complex forms where other comparable and relevant structural compounds could coexist. Implementation of quantum dots in MIPs improves their extraction features due to the presence of distinct functional sites. Quantum dots can be employed to modulate the size, detectability, and state of the imprinted materials, depending on the selected application. This review aims to summarize and illustrate the modern and innovative strategies based on the aggregation of MIPs with quantum dots. Quantum dot embedded MIPs can be exploited for simultaneous extraction, preconcentration, and detection of paclitaxel obtained from various sources.
Intrapleural Thrombolytics for Parapneumonic Effusion: A Network Metaanalysis
Authors: Sridharan Kannan , Sivaramakrishnan Gowri 
Published: September 2022

Objectives:
Intrapleural thrombolytics have been trialed for facilitating pleural fluid drainage
in patients with complicated parapneumonic effusion. The present study is a network metaanalysis
of randomized clinical trials (RCTs) that have evaluated these thrombolytics.

Methods:
Electronic databases (Medline, Cochrane CENTRAL, and Google Scholar) were searched
for appropriate RCTs evaluating the therapeutic effect of thrombolytics in patients with complicated
parapneumonic effusion. Mortality, the proportion of patients referred for surgical intervention, and
serious adverse events were the outcome measures. Random-effects model was used for generating
direct and mixed treatment comparison pooled estimates. Grading of the evidence for key comparisons
was carried out. Odds ratio with 95% confidence intervals was used to represent the pooled estimates.

Results:
Seventy-six studies were retrieved with the search strategy, of which 16 were included. No
significant differences were observed in mortality. Compared to normal saline, significantly less proportion
of patients was referred for surgical intervention with streptokinase (0.4, 0.2 to 0.8), urokinase
(0.4, 0.2 to 0.8), alteplase (0.3, 0.1 to 0.7), and alteplase + DNase (0.2, 0.1 to 0.7). DNase alone increased
the risk of referral to surgical intervention (3.4, 1.5 to 7.6). Only streptokinase was observed
with an increased risk of serious adverse events compared to normal saline (2.8, 1.1 to 7.1) and alteplase
(6.7, 1.1 to 39.9). Moderate quality of evidence was observed for streptokinase with normal saline
for the proportion of patients referred for surgical intervention, while either low or very low quality
strength was observed for all other comparisons.

Conclusion:
Streptokinase, urokinase, alteplase, and alteplase + DNase were observed in patients referred
for surgical interventions when used intrapleural in patients with parapneumonic effusion. Alteplase
+ DNase is likely to outperform others as it was observed with the least risk of patients referred
for surgical interventions. Until additional data emerges that changes the pooled estimates,
thrombolytics other than streptokinase are preferred due to the increased risk of serious adverse
events.
Youth Knife Crime in London and Croydon
Authors: Brenner Emily 
Published: September 2022

Rising rates of youth-involved knife crime in London and Croydon have created a culture of fear, drawing criticism of criminal justice practices which aim to tackle this issue. Research shows there is no one core motivator for knife crime among juveniles, but instead an array of possibilities for why young people engage in knife crime. Ranging from lack of community and youth centers to gangs preying on vulnerable young people, different reasons for involvement means creating a layered solution that isn’t one-size-fits-all. Opposing political approaches from the Conservative and Labour parties demonstrate how policy and political agendas play a role in juvenile crime, as well as present potential strategies for combating youth crime. The fallout of austerity measures and financial cuts to community and social services has been cited as a major factor in the rise of juvenile knife crime. This report seeks to demonstrate the aspects and potential causes of juvenile knife crime and criminality, and present possible solutions. Ultimately, a public health approach shows the potential to be effective, as noted by both researchers and young people at risk. Methods used to aid juveniles at risk of engaging in knife crime should account for the intersections of vulnerability. Resources including youth centers, mental health services, and a collaboration of social services would be beneficial in reducing levels of youth-involved knife crime.
Alcances de la pandemia de COVID-19 en la salud materno-infantil
Authors: Barría-Pailaquilén R.M. 
Published: September 2022

La pandemia por SARS-CoV-2 ha afectado directa e indirectamente los indicadores de salud y económicos a nivel mundial, entre ellos, los relacionados con aspectos de salud, sin duda alguna, la crisis de la COVID-19 ha agudizado problemas asociados con la salud materno-infantil en aquellos países en los que ya se experimentaban dificultades, una encuesta efectuada por la OMS a fin de establecer la continuidad de los servicios esenciales de salud durante la pandemia de COVID-19, determinó que 35 % de los países informaron interrupciones en los servicios de salud reproductiva, materna, neonatal, infantil, adolescente y nutricional, también menciona que los servicios suspendidos con mayor frecuencia fueron la planificación familiar y anticoncepción
La pandemia por SARS-CoV-2 ha generado severas repercusiones en la dinámica y organización de todos los servicios de salud, de tal manera que un desafío mayor para las naciones es intensificar los esfuerzos para sostener la atención sanitaria básica durante emergencias de salud pública, minimizar la interrupción en intervenciones terapéuticas y preventivas de los problemas de salud no relacionados con la pandemia, además de planificar cómo reanudar los servicios prepandémicos.
Propuesta teórica para el cambio de conducta en el consumo excesivo de alcohol en adolescentes
Authors: Jiménez-Padilla B.I. , Alonso-Castillo M.M. , Armendáriz-García N.A. , Flores-Garza P.L. 
Published: September 2022

Introducción: El consumo de alcohol en los adolescentes es un problema cada vez más frecuente y va en aumento debido a que el consumo episódico excesivo es una tendencia cada vez más común en esta población. Para el profesional de enfermería de primer nivel de atención, se vuelve necesario implementar herramientas sustentadas en evidencia científica como una alternativa factible que responda a las necesidades actuales.
Objetivo: Desarrollar una propuesta de aplicación a partir de la Teoría de Situación Específica del Modelo de Intención de Cambio (I-Change) enfocada al cambio de conducta del consumo excesivo de bebidas alcohólicas en adolescentes.
Desarrollo: Se utilizó la metodología de tres pasos propuesta por Fawcett. Para la revisión de literatura sobre consumo excesivo de bebidas alcohólicas, se emplearon términos en inglés y español, así como los operadores booleanos AND y OR en diversas bases de datos, posteriormente se construyó una estructura conceptual teórico-empírica de la propuesta de la Teoría de Situación Específica para el consumo excesivo de bebidas alcohólicas.
Conclusiones: La presente propuesta supone una alternativa para lograr el cambio de conducta del consumo excesivo de bebidas alcohólicas a través de un proceso motivacional de tres fases (premotivacional, motivacional y postmotivacional). Implementar esta propuesta, busca dar solucióna una problemática que genera una carga importante de salud en una población vulnerable. Los hallazgos derivados de su aplicación pueden aportar evidencia para la labor del profesional de enfermería en el campo de la prevención del consumo de alcohol.
Effect Of Posture Correction And Moderate Intensity Exercises On Respiratory System In Teenagers.
Authors: Sakshi Shah  , Dr. Poonam H. Patil  
Published: September 2022

Teenage is the time of shaping health behaviour and preventing postural defects and improving respiratory fitness. The teenagers possess insufficient knowledge about their respiratory system. Postural defects are commonly seen among teenagers due to lack of physical activity and poor postural habits which can lead to non harmonious development of organs and affect respiratory system as well. For efficient respiratory function, moderate intensity exercises with posture correction would be useful. There is a paucity of literature showing the effect of posture correction and moderate intensity exercises on respiratory system in teenagers, hence this study would be helpful to analyse the same. Objective of our study is to find out the effect of posture correction exercise on the respiratory system in teenagers and to find out the effect of moderate intensity exercises on the respiratory system in teenagers. The study was carried out in the karad area. The subjects were selected according to inclusion and exclusion criteria. Total 35 subjects participated in this study. Prior consent and assent form was taken. Aim and procedure were explained to the subjects in their preferred language before data collection. Pre and post assessment was done by a 6 minute walk test for respiratory function and flexicurve was measured using flexible ruler to recognize spinal postural defect. Peak flow meter was used to measure lung function In this study, 6minute walk test, peak flow meter and flexicurve showed statistically significant difference between pre and post treatment values. On the basis of the result of the study, it can be concluded that posture correction and moderate intensity exercises helps in improving respiratory function in teenagers.
PERBANDINGAN AKURASI PREDIKSI PASANG SURUT ANTARA METODE ADMIRALTY DAN METODE LEAST SQUARE DI PANTAI BATASUYA
Authors: Nurfadillah Nurfadillah 
Published: September 2022

Pemanfaatan Pemanfaatan Pantai Batusuya sebagian besar digunakan sebagai sumber mata percaharian bagi para nelayan di Desa Batusuya. Seiring berjalannya aktifitas tersebut, Pantai Batusuya juga mengalami penurunan daya dukung lingkungan. Untuk mengatasi hal tersebut, diperlukan perencanaan bangunan-bangunan pantai untuk mendukung pemanfaatan dan pengembangan wilayah sekitar pantai. Tujuan dari penelitian ini untuk menganalisis akurasi prediksi pasang surut pada daerah survei untuk berbagai keperluan dalam perencanaan bangunan pantai. Terdapat beberapa metode yang dapat digunakan untuk menentukan konstanta harmonik pasang surut selama periode tertentu, diantaranya metode admiralty dan least square. Dalam penelitian ini dilakukan analisa prediksi pasang surut dengan menggunakan data observasi selama 15 hari. Dari kedua metode tersebut dilakukan perhitungan tiap komponen pasang surutnya sehingga dapat dilakukan prediksi pasang surut dan dibandingkan hasilnya. Selisih nilai amplitudo terbesar terdapat pada komponen N2 perbandingan antara admiralty dan least square yakni sebesar -84,800 cm. Sedangkan untuk selisih beda fase terbesar terdapat pada komponen P1 yakni sebesar -258,610o. Berdasarkan bilangan Formzahl (F), didapat nilai F dengan metode admiralty yaitu 0,401, sedangkan dengan metode least square yaitu 0,486. Nilai RMSE yang dihasilkan metode least square lebih kecil yakni 2,115 cm dibandingkan metode admiralty yaitu sebesar 25,787 cm untuk panjang data 15 hari pada prediksi pasang surut bulan pertama
KARAKTERISTIK TANAH TERDAMPAK DAN TIDAK TERDAMPAK LIKUIFAKSI BERDASARKAN UJI SWEDISH WEIGHT SOUNDING PADA KELURAHAN PETOBO
Authors: Kurniawan Sigit 
Published: September 2022

Gempa bumi 28 September 2018 yang mengguncang Kota Palu dan sekitarnya dengan kekuatan 7,4 MW memicu terjadinya likuifaksi di beberapa lokasi, salah satunya adalah di sebagian wilayah Petobo. Likuifaksi yang terjadi di daaerah ini mengakibatkan pergeseran tanah yang masif sehingga menimbulkan kerugian material dan korban jiwa.Penelitian ini bertujuan untuk mengetahui karakteristik tanah terdampak dan tidak terdampak likuifaksi berdasarkan uji Swedish Weight Sounding pada Kelurahan Petobo. Pengujian lapangan yang dilakukan yaitu dengan alat uji Swedish Weight Sounding. Adapun pengujian laboratorium yang dilakukan meliputi pengujian Analisa saringan dan batas-batas Atterberg. Hasil yang diperoleh dari penelitian ini meliputi hasil pengujian laboratorium dan pengujian di lapangan. Untuk hasil pengujian di laboratorium, jenis tanah berbutir halus yang didapat pada lokasi tersebut yaitu jenis tanah CL dan CL-ML. Sedangkan untuk hasil pengujian lapangan, nilai Nsw di daerah tidak terdampak berkisar antara 0-250 n/m, nilai Nsw untuk daerah terdampak berkisar antara 8-72 n/m, nilai qa di daerah tidak terdampak berkisar antara 0-230 kN/m2, nilai qa untuk daerah terdampak berkisar antara 0-167,6 kN/m2, nilai qu untuk daerah tidak terdampak berkisar antara 30-180 kN/m2, dan nilai qu untuk daerah terdampak berkisar antara 30-133,2 kN/m2.
PENGARUH PERUBAHAN TITIK LEMBEK ASPAL AKIBAT PENAMBAHAN VIATOP66 TERHADAP KARAKTERISTIK CAMPURAN HRS-WC
Authors: Anshory Reza Maulana 
Published: September 2022

Peningkatan nilai Titik lembek aspal juga mempengaruhi karakteristik dari campuran HRS-WC. Tujuan penelitian ini untuk mengetahui pengaruh perubahan Titik lembek aspal akibat penambahan Viatop66 terhadap karakteristik perkerasan aspal beton lapisan Aus (HRS-WC). Penambahan variasi kadar viatop66 dalam aspal adalah 0,0% ; 1,0%; 2,0%; 3,0%; 4,0%; dan 5,0% terhadap berat aspal. Penentuan Kadar Aspal Optimum (KAO) campuran HRS-WC menggunakan Metode Marshall. Hasil penelitian mendapatkan bahwa peningkatan nilai Titik lembek aspal akibat penambahan viatop66 ke dalam aspal dapat meningkatkan nilai kepadatan dan VFB campuran HRS-WC dengan persentase peningkatan tertinggi 0,67% untuk kepadatan dan 4,06% untuk VFB campuran HRS-WC pada nilai Titik Lembek Aspal 52,48 °C, menurunkan nilai VIM dan VMA campuran HRS-WC dengan persentase penurunan 11,92% untuk VIM dan 3,24% untuk VMA campuran HRS-WC pada nilai Titik Lembek Aspal 52,48 °C, menurunkan nilai flow serta meningkatkan Stabilitas dan MQ marshall campuran HRS-WC. Peningkatan nilai Titik lembek aspal akibat penambahan viatop66 ke dalam aspal juga meningkatkan nilai stabilitas marshall sisa di atas 90 % yang mengartikan perubahan nilai Titik Lembek Aspal akibat penambahan viatop66 dapat membuat aspal tahan terhadap perubahan lingkungan sekitar
STUDI HIDROGEOLOGI TERHADAP KAPASITAS DEBIT AIR TANAH MENGGUNAKAN METODE PUMPING TEST PADA DAERAH BIROMARU KABUPATEN SIGI
Authors: Hamad Harly 
Published: September 2022

Groundwater is a natural resource that can be renewed naturally, but the time of renewal is very relative. In meeting the needs of groundwater in the community, it is necessary to strive for groundwater produced can be periodically available. The purpose of this study was to aquifer condition and determine the capacity for groundwater discharge in the Biromaru area, precisely in Lolu Village. The data collection method used is the pumping test long-term test method and the analytical method used is the Neuman curve-fitting method and Theis recovery method. Based on the test and aquifer test results of lithological correlation, value of transmissivity 180,001 m2/day, storativity 3,7 x 10-3, specific yield 2,56 x 10-2, hydraulic conductivity 14,572, permeability 16,488. The potential for groundwater discharge in the study area is between 226,067 cm3/day. The maximum available discharge is 146.88 m3/day, while the groundwater discharge that has been exploited from production wells in the research area is ≥363,461.28 m3 which has been used for ±52 weeks so that the pumping discharge does not exceed the potential groundwater discharge.