bluuebunny/crossref_metadata_2025_split huggingface dataset:
At what size do anti-injury shelters start to play a positive role in the culture of Portunus trituberculatus?
Authors: He Jie , Yu Huaihua , Wan Litao , Zhang Dongxu , Xu Wenjun 
Published: September 2022

Based on the existing research, special plastic baskets were used as anti-injury shelters to explore the hidden behavior and molting growth of Portunus trituberculatus (Swimming crab) different initial body weights (Group A: 5.74 ± 0.11 g, Group B: 12.06 ± 0.15 g, Group C: 24.82 ± 0.41 g, Group D: 49.55 ± 1.12 g and Group E: 94.32 ± 1.19 g). The results showed that the shelter occupancy rate (SOR) during the daytime with all different body weights were significantly higher than that at night (P &lt; 0.05), and the SOR was proportional to the crab’s body weight, among them, SOR in group E was as high as 71.52%. Meanwhile, the territorial consciousness of smaller body weight crabs (Groups A, B and C) was poor, and there was a phenomenon in which multiple individuals occupied the same shelter at the same time, while the individuals with the body weight of approximately 50 g and above (Groups D and E) had strong territorial consciousness, and most of them occupied one shelter alone. In all groups, more individuals chose to molt in the shelter on condition that there existed shelter, and the rate of molting in group B was high up to 81.15% and that in other groups was about 60%. Although the existence of shelter had no significant influence on the molting interphase (MI) of swimming crab in each group, the body weight growth rate (WGR) and carapace width growth rate (WGRC) after molting were increased by shelter compared with those without shelter. In addition, shelter could improve the survival rate (SR) in each group, and the effect of shelter on individuals with large body weight was relatively more obvious, in which the SR in Group D was significantly improved (P &lt; 0.05). In general, the shelter can play a positive role in the whole growth of swimming crab. Therefore, it is necessary to set up the shelter in advance before the seedlings are put into production, which is helpful to increase the yield of swimming crab.
Effect of micro-magnesium oxide admixture on rheological and compressive strength properties of class G well cement
Authors: Chen Weiqing , Mahmoud Ahmed Abdulhamid , Elkatatny Salaheldin 
Published: September 2022

Rheological property tuning is one key aspect of oil-well cement, not only affecting the cement slurry placement but also indirectly impacting other cementing properties such as the bonding strength and compressive strength. However, the research is scant on the rheological properties of blending magnesium oxide with class G oil-well cement, despite some studies having been conducted on its impacts on shrinkage compensation, compressive strength, bonding strength, and permeability properties of oil-well cement. This work studies the effects of micro-sized magnesium oxide on the rheological properties and compressive strength of the formulated API Class G oil-well cement slurries. Two types of micro-sized magnesium oxide (50 μm and 100 μm) were used as the mineral admixture at different dosages (3%, 9%). The base formulated slurry sample was incorporated with the silica flour and several commercialized additives such as retarder, fluid loss control agent, and defoamer. A batch of flow tests have been conducted by the use of a digital viscometer at two different temperatures, 25 and 88°C. The compressive strength has also been measured after curing the samples with the same formulation and conditions for 7 days. The variations of the rheological properties (plastic viscosity, yield stress, and gel strength), shear stress–shear rate correlations, and shear-thinning/thickening behavior are impacted by the temperature, the type, and dosage of magnesium oxide. The plastic viscosity of the tested slurries decreased by 27.0% (type II, 9%, 25°C) and 15.1% (type II, 3%, 88°C), respectively, and the yield stress increased by 258.5% (type II, 3%, 88°C) and 53.9% (type II, 9%, 25°C). The gel strength generally increases as the magnesium oxide dosage increases. However, all tested slurry samples show shear-thinning behavior and non-Newtonian characteristics. Among the tested slurry samples, it is found that better rheological performance is achieved when incorporating magnesium oxide with a smaller particle size. On the other side, the specimens of mixed magnesium oxide with a bigger particle size and medium dosage outperform their rival with a smaller particle size in compressive strength.
Worsening of asthma control after COVID-19
Authors: Agondi Rosana Câmara , Menechino Natália , Marinho Ana Karolina Barreto Berselli , Kalil Jorge , Giavina-Bianchi Pedro 
Published: September 2022

BackgroundSARS-CoV-2 enters lung cells via angiotensin-converting enzyme 2 (ACE2) receptor. Several studies suggest that interleukin-13, an important cytokine involved in T2 inflammation, reduces ACE2 expression, and therefore, asthma would not be a significant risk factor for the development of severe COVID-19. However, several asthma-related risk factors should be valued during the concurrent occurrence of asthma and COVID-19. The purpose of this study was to compare the evolution of asthma in patients who had COVID-19 with those who did not have the disease.MethodsThis was an observational and retrospective study involving asthmatic patients followed up at a tertiary center. Patients were assessed for severity of asthma, atopy, comorbidities, and COVID-19. Worsening of asthma was considered when, during the period of Sept 2020 to Oct 2021, patients referred an increasing of asthma symptoms and a need to increment their maintenance therapy.ResultsThis study included 208 asthmatic patients, the mean age was 52.75 years, 79.81% were atopic asthmatics, and 59 (28.37%) had laboratory-confirmed coronavirus disease. Of all patients infected with the SARS-CoV-2, eleven (18.64%) needed hospitalization and required oxygen supply with an O2 mask. Comparing the worsening of asthma between patients who had COVID-19 and those who had not the disease, there was a statistically significant difference, 33.90 vs. 11.41%, respectively (p &lt; 0.001). There was no statistical significance regarding asthma comorbidities.ConclusionThis study assessed a group of asthmatic patients that had COVID-19, and that although the respiratory symptoms related to COVID-19 were mild to moderate, a subgroup of these asthmatic patients evolved with a chronic worsening of their asthma requiring an increment in asthma medication to control the disease.
The association between Herpes simplex virus type 2 and asthma: A cross-sectional study from National Health and Nutrition Examination Survey 1999–2016
Authors: Zhang Xiaofei , Jiang Yalin , Qian Hui , Qu Xiangkun , Han Kexing 
Published: September 2022

BackgroundThe association between Herpes simplex virus type 2 (HSV-2) infection, a common infectious disease that increases the incidence of multisystem diseases, and asthma was less well studied. The aim of this study was to investigate the association between HSV-2 infection and the prevalence of asthma.Materials and methodsWe used data from National Health and Nutrition Examination Survey (NHANES) 1999–2016 for analysis. The study population included was limited to those aged 20–45 years and contained complete information on HSV-2 infection and asthma. We calculated the prevalence of HSV-2, asthma, and HSV-2 combined with asthma separately. The association between HSV-2 infection and asthma was analyzed using multiple logistic regression. We also performed stratified analyses to reduce bias and to find sensitive cohorts.ResultsThe prevalence of HSV-2 infection was decreasing with change in time period (P for trend &lt; 0.01), but the prevalence of asthma was increasing (P for trend &lt; 0.01). The prevalence of HSV-2 infection was higher in those with asthma than in non-asthma participants. A positive association was found between HSV-2 infection and asthma [odds ratio (OR) = 1.15, 95% CI: 1.04–1.27]. Subgroup analysis showed that this positive association was more pronounced in participants who were male, White, 30 years ≤ age ≤ 40 years, body mass index (BMI) ≤ 28 kg/m2, 1.39 ≤ ratio of family income to poverty (PIR) &lt; 3.49 and smokers.ConclusionThere was a positive association between HSV-2 infection and asthma, and participants who were male, White race, 30 years ≤ age &lt; 40 years, BMI ≥ 28 kg/m2, 1.39 ≤ PIR &lt; 3.49, and smokers should receive more attention.
Long-term renal and cardiovascular outcome of living kidney donors: A single-center retrospective observation study
Authors: Colucci Vincenza , Gallo Pasquale , Simone Simona , Morrone Luigi , Alfieri Carlo Maria , Gesualdo Loreto , Castellano Giuseppe 
Published: September 2022

BackgroundThe nephrectomy for donation reduces the renal parenchyma and glomerular filtration rate (GFR). It is important to understand the clinical consequences of kidney donation by a living donor.MethodsIn this single-center, observational, retrospective study, we defined the renal and cardiovascular outcomes of living kidney donors. We analyzed data of 124 donors who donated at the Kidney Transplant Center (TC) of Bari between February 2002 and December 2018. Biometric data collected at visit 0, that is, at the time of the study of the donor candidate, and at visit 1, or rather at the last nephrological checkup (October-2018/August-2019) were compared.ResultsAn overall drop in GFR of 29 mL/min was observed over the analyzed period of 81+/-59 months. At visit 1, two donors developed chronic renal failure, including one in ESKD who underwent a kidney transplant. No relationship between age at donation and GFR drop was found. A trend toward an increase in obese people was reported; 28% of patients had compensated dyslipidemia and 35% were treated for hypertension. During the follow-up time, 3% had major cardiovascular events and 24% were lost to follow-up. One patient died.ConclusionThe age of the donor does not represent a basic element for reducing GFR or for the occurrence of major cardiovascular events. Furthermore, older donor candidates, in optimal health, should not be excluded from the donation. It is important to promote careful and timely follow-up of the donor, preventing the most common clinical consequences of nephrectomy, in consideration of the poor compliance of a large part of donors over the long-term post-donation period.
Epidemiological analysis of septic shock in the plateau region of China
Authors: Li Qianwei , Chai Wenzhao , Wang Xiaoting , Cheng Li , Cai Xin , Fu Jianlei , Pan Wenjun , Lin Guoying 
Published: September 2022

PurposeLittle epidemiological data exist on patients with severe infection in the plateau region of China, and the data that do exist are lacking in quality. Using the medical records of patients with severe infection in the Department of Intensive Medicine (intensive care unit; ICU) of the People's Hospital of Tibet Autonomous Region, this study analyzed the epidemiological and clinical characteristics of patients with septic shock in plateau area (Tibet), with the ultimate aim of reducing the incidence and mortality from this condition.MethodsClinical data on 137 patients with septic shock in the studied ICU from November 2017 to October 2019 were retrospectively analyzed using SPSS, Version 21.0.ResultsAmong the 137 patients with septic shock, there were 47 survivors and 90 in-hospital or post-discharge deaths. There were 91 male patients and 46 female patients. The incidence of septic shock was 11.3%, and mortality rate was 65.7%. Median age was 55 years old, median APACHE-II score on the day of admission was 17, median SOFA score was 11, and median number of organ injuries was one. APACHE-II score (P = 0.02), SOFA score (P &lt; 0.001), and the number of organ injuries (P &lt; 0.001) were higher among patients who died than among survivors. The infections were mainly pulmonary and abdominal, and the main pathogen was gram-negative bacteria.ConclusionThe incidence and mortality of septic shock in ICU wards in Tibet are very high. The APACHE-II score, SOFA score, and the number of organ damage on the first day after diagnosis are independent risk factors for septic shock. To some extent, this study reflects the epidemiological characteristics of septic shock in the plateau region of China (≥ 3,650 m above sea level) and provides data that can support the prevention and treatment of sepsis in the future. More and deeper epidemiological studies of septic shock are necessary.
Migraine aura-like symptoms at onset of stroke and stroke-like symptoms in migraine with aura
Authors: Scutelnic Adrian , Kreis Lukas A. , Beyeler Morin , Heldner Mirjam R. , Meinel Thomas R. , Kaesmacher Johannes , Hakim Arsany , Arnold Marcel , Fischer Urs , Mattle Heinrich P. , Schankin Christoph J. , Jung Simon 
Published: September 2022

Background and objectivesIn general, suddenly occurring neurological deficits, i.e., negative neurological symptoms, are considered symptoms of focal cerebral ischemia, while positive irritative symptoms with gradual onset are viewed as the characteristics of migraine aura. Nevertheless, cortical spreading depolarization, the pathophysiological basis of migraine aura, has also been observed in acute ischemic stroke. The aim of our study was to determine the frequency of migraine aura-like symptoms at ischemic stroke onset and stroke-like symptoms in migraine with aura.MethodsWe interviewed 350 consecutive patients with ischemic stroke and 343 with migraine with aura using a structured questionnaire. Stroke diagnosis was confirmed by imaging, and migraine with aura was diagnosed according to the current criteria of the International Headache Society. Patients with wake-up strokes or severe cognitive deficits that precluded a useful interview were excluded from the study.ResultsSeventy-eight patients with stroke (22.3%) reported visual symptoms, 145 (41.4%) sensory symptoms, 197 (56.3%) a paresis, and 201 patients (57.4%) more than one symptom, compared to 326 migraine patients with aura (95%) with visual symptoms (P &lt; 0.001), 175 (51%) with sensory symptoms (p = 0.011), 50 (14.6%) with paresis (P &lt; 0.001), and 211 (61.5%) with more than one symptom (p = 0.27). Among patients with stroke, migraine-like symptoms were frequent: 36 patients (46.2%) with visual disturbance and 78 (53.8%) with sensory symptoms experienced irritative sensations. Paresis-onset in stroke lasted longer than 5 min in 43 patients (21.8%). Spreading of sensory and motor symptoms occurred in 37 (25.5%) and 37 (18.8%) patients, respectively. Stroke-like negative symptoms in migraine with aura occurred in 39 patients (12%) with visual symptoms, in 55 (31.4%) with sensory symptoms, and paresis appeared suddenly in 14 patients (28%). More than one symptom in succession occurred in 117 patients with stroke (58.2%) and in 201 migraine with aura patients (95.3%; P &lt; 0.001).ConclusionMany patients with stroke experience migraine-like symptoms at stroke onset, and many migraine with aura patients have stroke-like symptoms. Though overall the symptom frequencies of the two groups are significantly different, clarifying the differential diagnosis in an individual patient requires additional history elements, physical findings, or results of ancillary investigations.
Neurofeedback in patients with frontal brain lesions: A randomized, controlled double-blind trial
Authors: Annaheim Christine , Hug Kerstin , Stumm Caroline , Messerli Maya , Simon Yves , Hund-Georgiadis Margret 
Published: September 2022

BackgroundFrontal brain dysfunction is a major challenge in neurorehabilitation. Neurofeedback (NF), as an EEG-based brain training method, is currently applied in a wide spectrum of mental health conditions, including traumatic brain injury.ObjectiveThis study aimed to explore the capacity of Infra-Low Frequency Neurofeedback (ILF-NF) to promote the recovery of brain function in patients with frontal brain injury.Materials and methodsTwenty patients hospitalized at a neurorehabilitation clinic in Switzerland with recently acquired, frontal and optionally other brain lesions were randomized to either receive NF or sham-NF. Cognitive improvement was assessed using the Frontal Assessment Battery (FAB) and the Test of Attentional Performance (TAP) tasks regarding intrinsic alertness, phasic alertness and impulse control.ResultsWith respect to cognitive improvements, there was no significant difference between the two groups after 20 sessions of either NF or sham-NF. However, in a subgroup of patients with predominantly frontal brain lesions, the improvements measured by the FAB and intrinsic alertness were significantly higher in the NF-group.ConclusionThis is the first double-blind controlled study using NF in recovery from brain injury, and thus also the first such study of ILF NF. Although the result of the subgroup has limited significance because of the small number of participants, it accentuates the trend seen in the whole group regarding the FAB and intrinsic alertness (p = 0.068, p = 0.079, respectively). We therefore conclude that NF could be a promising candidate promoting the recoveryfrom frontal brain lesions. Further studies with larger numbers of patients and less lesion heterogeneity are needed to verify the usefulness of NF in the neurorehabilitation of patients with frontal brain injury (NCT02957695 ClinicalTrials.gov).
Lactobacillus plantarum ST-III culture supernatant ameliorates alcohol-induced cognitive dysfunction by reducing endoplasmic reticulum stress and oxidative stress
Authors: Xu Zeping , Zhang Jinjing , Wu Junnan , Yang Shizhuo , Li Yuying , Wu Yuyu , Li Siyuan , Zhang Xie , Zuo Wei , Lian Xiang , Lin Jianjun , Jiang Yongsheng , Xie Longteng , Liu Yanlong , Wang Ping 
Published: September 2022

BackgroundLong-term alcohol exposure is associated with oxidative stress, endoplasmic reticulum (ER) stress, and neuroinflammation, which may impair cognitive function. Probiotics supplements can significantly improve cognitive function in neurodegenerative diseases such as Alzheimer’s disease. Nevertheless, the effect of Lactobacillus plantarum ST-III culture supernatant (LP-cs) on alcohol-induced cognitive dysfunction remains unclear.MethodsA mouse model of cognitive dysfunction was established by intraperitoneal injection of alcohol (2 g/kg body weight) for 28 days. Mice were pre-treated with LP-cs, and cognitive function was evaluated using the Morris water maze test. Hippocampal tissues were collected for biochemical and molecular analysis.ResultsLP-cs significantly ameliorated alcohol-induced decline in learning and memory function and hippocampal morphology changes, neuronal apoptosis, and synaptic dysfunction. A mechanistic study showed that alcohol activated protein kinase R-like endoplasmic reticulum kinase (PERK) signaling and suppressed brain derived neurotrophic factor (BDNF) levels via ER stress in the hippocampus, which LP-cs reversed. Alcohol activated oxidative stress and inflammation responses in the hippocampus, which LP-cs reversed.ConclusionLP-cs significantly ameliorated alcohol-induced cognitive dysfunction and cellular stress. LP-cs might serve as an effective treatment for alcohol-induced cognitive dysfunction.
Brain structural and functional changes during menstrual migraine: Relationships with pain
Authors: Wang Zi-wen , Yin Zi-han , Wang Xiao , Zhang Yu-tong , Xu Tao , Du Jia-rong , Wen Yi , Liao Hua-qiang , Zhao Yu , Liang Fan-rong , Zhao Ling 
Published: September 2022

ObjectivesMenstrual migraine (MM) is a special type of migraine associated with the ovarian cycle, which imposes a marked burden on female patients. However, the pathogenesis of MM is not completely understood. We investigated gray matter volume (GMV) and functional connectivity (FC) alterations in patients with MM to explore whether there are changes in resting-state FC (rsFC) in brain regions with structural GMV abnormalities and investigated their relevance to pain and concomitant symptoms.MethodsSeventy-five patients with MM and 54 female healthy controls underwent functional magnetic resonance imaging and examination. The patients completed a patient’s headache diary, which included the frequency of migraine attacks, a visual analog scale for pain, a self-rating anxiety scale, and a self-rating depression scale. We used voxel-based morphometry (VBM) to examine the GMV differences between the MM and healthy control groups. The identified brain areas were selected as seeds to assess functional changes in the MM group. Correlation analysis between the altered VBM/rsFC and clinical outcomes was performed.ResultsCompared with healthy controls, patients with MM showed decreased GMV in the right anterior cingulum cortex (ACC) and increased GMV in the right superior parietal cortex. Pearson’s correlation analysis illustrated that only GMV in the right ACC was associated with visual analogue scale pain scores in the MM group. RsFC with the ACC as the seed showed that patients with MM exhibited increased FC between the ACC and the left inferior temporal gyrus, bilateral angular gyrus, and right precuneus. Correlation analysis showed that the change in FC between the right ACC and the right precuneus was positively correlated with headache frequency, and the change in FC between the right ACC and the right angular gyrus was positively correlated with the depression score.ConclusionOur results suggested that the ACC may be an important biomarker in MM, and its structural and functional impairments are significantly associated with the severity of pain and pain-related impairment of emotion in patients with MM. These findings demonstrated that headache-associated structural and functional abnormalities in the ACC may can provide integrative evidence on the physiological mechanisms of MM.
Effects of gestational diabetes mellitus and assisted reproductive technology treatment on the risk of preterm singleton birth
Authors: Gao Rui , Zhao Ke , Zhou Jiaxin , Wang Xiaona , Liu Ting , Lian Shaoyan , Li Jieying , Huang Yuanyan , Qiu Chuhui , Wu Yuxiao , He Jiang , Liu Chaoqun 
Published: September 2022

BackgroundAlthough assisted reproductive technology (ART) plays a critical role in reducing infertility, ART pregnant women are reported at higher risk of preterm birth (PTB). Besides, women undergoing ART encounter a higher risk of developing gestational diabetes mellitus (GDM). However, existing studies on the combined effect of ART treatment and GDM on PTB risk are sparse.MethodsThis population-based retrospective cohort study used nationwide birth certificate data from the US National Vital Statistics System 2015-2019. All mothers who had a singleton live birth without pre-pregnancy diabetes were included. Multivariable logistic regression models were used to estimate the odds ratio (OR) of PTB.ResultsWe finally included 18,140,241 American mother-infant pairs. The overall rate of PTB was 7.92% (n = 1,436,328). The PTB rate for non-ART mothers without GDM, ART mothers without GDM, non-ART mothers with GDM, and ART mothers with GDM were 7.67, 10.90, 11.23, and 14.81%, respectively. The incidence of GDM in ART mothers (10.48%) was significantly higher than in non-ART mothers (6.26%). After adjusting for potential confounders, compared with non-ART mothers without GDM, the PTB risk was significantly increased for ART mothers without GDM (AOR: 1.47, 95% CI 1.44-1.50), non-ART mothers with GDM (AOR:1.35, 95% CI 1.34-1.36) and ART mothers with GDM (AOR: 1.82, 95% CI 1.74-1.90) respectively, showing an increasing tendency. This phenomenon was stable among mothers in all groups of mothers older than 25 years.ConclusionTo prevent PTB, effective approaches for the prevention of GDM are crucial to mothers who conceived through ART.