bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turning a lost reef ecosystem into a national restoration program
Authors: McAfee Dominic , McLeod Ian M. , Alleway Heidi K. , Bishop Melanie J. , Branigan Simon , Connell Sean D. , Copeland Craig , Crawford Christine M. , Diggles Ben K. , Fitzsimons James A. , Gilby Ben L. , Hamer Paul , Hancock Boze , Pearce Robert , Russell Kylie , Gillies Chris L. 
Published: August 2022

AbstractAchieving a sustainable socioecological future now requires large‐scale environmental repair across legislative borders. Yet, enabling large‐scale conservation is complicated by policy‐making processes that are disconnected from socioeconomic interests, multiple sources of knowledge, and differing applications of policy. We considered how a multidisciplinary approach to marine habitat restoration generated the scientific evidence base, community support, and funding needed to begin the restoration of a forgotten, functionally extinct shellfish reef ecosystem. The key actors came together as a multidisciplinary community of researchers, conservation practitioners, recreational fisher communities, and government bodies that collaborated across sectors to rediscover Australia's lost shellfish reefs and communicate the value of its restoration. Actions undertaken to build a case for large‐scale marine restoration included synthesizing current knowledge on Australian shellfish reefs and their historical decline, using this history to tell a compelling story to spark public and political interest, integrating restoration into government policy, and rallying local support through community engagement. Clearly articulating the social, economic, and environmental business case for restoration led to state and national funding for reef restoration to meet diverse sustainability goals (e.g., enhanced biodiversity and fisheries productivity) and socioeconomic goals (e.g., job creation and recreational opportunities). A key lesson learned was the importance of aligning project goals with public and industry interests so that projects could address multiple political obligations. This process culminated in Australia's largest marine restoration initiative and shows that solutions for large‐scale ecosystem repair can rapidly occur when socially valued science acts on political opportunities.
Facilitating the adoption of high‐throughput sequencing technologies as a plant pest diagnostic test in laboratories: A step‐by‐step description
Authors: Lebas Benedicte , Adams Ian , Al Rwahnih Maher , Baeyen Steve , Bilodeau Guillaume J. , Blouin Arnaud G. , Boonham Neil , Candresse Thierry , Chandelier Anne , De Jonghe Kris , Fox Adrian , Gaafar Yahya Z. A. , Gentit Pascal , Haegeman Annelies , Ho Wellcome , Hurtado‐Gonzales Oscar , Jonkers Wilfried , Kreuze Jan , Kutjnak Denis , Landa Blanca , Liu Mingxin , Maclot François , Malapi‐Wight Martha , Maree Hano J. , Martoni Francesco , Mehle Natasha , Minafra Angelantonio , Mollov Dimitre , Moreira Adriana , Nakhla Mark , Petter Françoise , Piper Alexander M. , Ponchart Julien , Rae Robbie , Remenant Benoit , Rivera Yazmin , Rodoni Brendan , Roenhorst Johanna W. , Rollin Johan , Saldarelli Pasquale , Santala Johanna , Souza‐Richards Rose , Spadaro Davide , Studholme David J. , Sultmanis Stefanie , van der Vlugt René , Tamisier Lucie , Trontin Charlotte , Vazquez‐Iglesias Ines , Vicente Claudia S. L. , Vossenberg Bart T. L. H. , Wetzel Thierry , Ziebell Heiko , Massart Sebastien 
Published: August 2022

AbstractHigh‐throughput sequencing (HTS) is a powerful tool that enables the simultaneous detection and potential identification of any organisms present in a sample. The growing interest in the application of HTS technologies for routine diagnostics in plant health laboratories is triggering the development of guidelines on how to prepare laboratories for performing HTS testing. This paper describes general and technical recommendations to guide laboratories through the complex process of preparing a laboratory for HTS tests within existing quality assurance systems. From nucleic acid extractions to data analysis and interpretation, all of the steps are covered to ensure reliable and reproducible results. These guidelines are relevant for the detection and identification of any plant pest (e.g. arthropods, bacteria, fungi, nematodes, invasive plants or weeds, protozoa, viroids, viruses), and from any type of matrix (e.g. pure microbial culture, plant tissue, soil, water), regardless of the HTS technology (e.g. amplicon sequencing, shotgun sequencing) and of the application (e.g. surveillance programme, phytosanitary certification, quarantine, import control). These guidelines are written in general terms to facilitate the adoption of HTS technologies in plant pest routine diagnostics and enable broader application in all plant health fields, including research. A glossary of relevant terms is provided among the Supplementary Material.
Macroinvertebrate distribution associated with environmental variables in alpine streams
Authors: Becquet Juliette , Lamouroux Nicolas , Condom Thomas , Gouttevin Isabelle , Forcellini Maxence , Launay Bertrand , Rabatel Antoine , Cauvy‐Fraunié Sophie 
Published: August 2022

Abstract

Ongoing hydrological alterations due to climate change and anthropogenic uses of water have major implications for freshwater biodiversity. Quantifying the relative effects of environmental variables on macroinvertebrates is required to predict biological responses to hydrological alterations. To date, no study simultaneously examined the effects of physico‐chemistry, hydraulics, and hydrology on the distribution of alpine macroinvertebrate communities and taxa. In this study, we aimed to quantify the relative correlation between these environmental variables and macroinvertebrate community composition and structure.

We sampled macroinvertebrates at 66 stream sites located in three catchments in the French Alps. We characterised the proximate habitat at each site using 11 variables describing measured physico‐chemistry and hydraulics, and simulation‐based hydrology. We described relationships between community structure and the environment using a co‐inertia analysis and modelled individual taxa abundance with generalised linear mixed models.

The co‐inertia revealed a significant co‐structure between the environmental and macroinvertebrate matrices. Glacier‐influenced sites with high turbidity and summer flow exhibited similar community composition with low total abundance. Sources at high altitude and sites with low glacial influence, exhibiting high summer flow and flow velocity, were dominated by Diamesinae, Rhithrogena spp., Dictyogenus spp., and Baetis alpinus. Streams fed by rainfall/snowmelt and valley sources, associated with higher temperature, conductivity, and monthly discharge variability were characterised by higher richness and abundances. Models indicated that the three types of proximate habitat variables significantly contributed to the macroinvertebrate distribution. Turbidity was strongly negatively associated with macroinvertebrate abundances. Increasing flow velocity and summer flow had significant (mainly negative) effect in 43% of models.

The co‐structure between communities and proximate habitat variables was shared by the three catchments. For most individual taxa, catchment identity did not influence abundance models and cross‐validations indicated transferable effects of proximate habitat variables among alpine catchments.

Our results can be used to infer responses of alpine macroinvertebrates to multivariate environmental changes. Understanding the relationships between macroinvertebrates and environmental variables help to predict how communities and taxa will be affected by habitat alterations due to ongoing hydrological changes and resulting physico‐chemical conditions.
Negativity bias in welfare policy feedback effects on mass publics
Authors: Zhang Youlang , Wang Qiang , Zhao Menghan 
Published: August 2022

AbstractExtant studies on policy feedback effects have examined how a welfare increase, rather than a decrease, might shape policy attitudes or political engagement. Nevertheless, exploring the effects of welfare decrease on the mass public is significant because of its increasingly crucial relevance to public policy practices worldwide. Using a unique longitudinal national panel survey dataset (2015–2017) related to China's Minimum Living Standard Guarantee Program, this study examines how welfare program benefits influence the policy perceptions and political participation of more than 10,000 economically disadvantaged respondents. A series of analyses showed that all else being equal, starting to receive program benefits in a year does not necessarily produce a positive effect on policy perceptions or on political participation. However, being deprived of program benefits in a year has a significantly negative effect on policy perceptions and political participation. These findings concur with the negativity bias proposed in the psychology literature and contribute to the understanding of the micro‐level foundations of welfare policy feedback effects on the mass public.
Research on deep learning method recognition and a classification model of grassland grass species based on unmanned aerial vehicle hyperspectral remote sensing
Authors: Zhu Xiangbing , Bi Yuge , Du Jianmin , Gao Xinchao , Zhang Tao , Pi Weiqiang , Zhang Yanbin , Wang Yuan , Zhang Haijun 
Published: August 2022

AbstractIdentifying grass species in grasslands based on unmanned aerial vehicle hyperspectral remote sensing is the basis and premise of hyperspectral remote sensing when applied to grassland degradation monitoring and research. The small targets and mixed pixels involved grass species identification in grasslands creates problems, making identification cumbersome and classification accuracy difficult. This study involved the construction of an unmanned aerial vehicle hyperspectral remote sensing system using hyperspectral data of grass species in desert habitats that had been collected under natural light. A multi‐resolution combined with a 1 × 1 feature map was formed by multiscale convolution, and grass species data were extracted from hyperspectral fine‐grained feature data from grasslands. A recognition and classification model for degradation indicator species CNN was constructed using max pooling to retain the maximum amount of feature detail and up‐sampling, reconstructing the feature space and feature fusion to smooth the edge texture of the data and enhance the weak data to alleviate the imbalance among samples. The results showed that the overall identification accuracy of the model for grassland species reached 98.78%, and the kappa coefficient reached 0.92, realizing the high‐precision identification of grassland species, which laid the foundation for grassland species detection and research based on unmanned aerial vehicle hyperspectral imagery. In addition, the proposed degradation indicator species CNN model provides a useful reference for the identification and classification of small targets with mixed pixels.
Testimonios de las atravesadas: A borderland existence of women of color faculty
Authors: Cho Katherine S. , Banda Racheal M. , Fernández Érica , Aronson Brittany 
Published: August 2022

AbstractThe temporalities of COVID‐19 and resultant economic crisis, along with increased visibility of white supremacy and anti‐Blackness, have exacerbated the longstanding challenges Women of Color (WOC) faculty experience, particularly around negotiating labor and navigating the academy. Through Anzaldúa's borderlands framework, and an interwoven methodology of testimonios and pláticas, this paper's findings illuminate how the fixed, shifting, and messy boundaries of academic work have, especially for WOC faculty working through COVID‐19, violated the limits of the personal and professional, intruded into the homes as sacred spaces, and continued and expanded demands to provide labor. Institutions have placated these fraught borders with professional development and networks of mentorship—all while pivoting away from addressing the material and structural conditions that disintegrate the borders, particularly for WOC faculty. By exploring the layered complexities of traversing the academy–a space not made for our existence as WOC within them–we offer a nuanced understanding of academic borderlands. As a part of this, we highlight our resistance to carve out spaces of solidarity and collectivity in the face of Eurocentric, individualistic institutions to imagine new possibilities, a practice necessary toward transforming the academy.
Optimized dual therapy for treatment‐naive patients of Helicobacter pylori infection: A large‐scale prospective, multicenter, open‐label, randomized controlled study
Authors: Han Ying‐Ying , Long Hui , Lin Ya , He Qiong , Chen Wei‐Gang , Ding Xiang‐Wu , Zhou Lin , An Ping , Wang Fen , Zhang Zhen‐Yu , Hu Yun‐Lian , Li Pei‐Yuan 
Published: August 2022

AbstractBackgroundThe efficacy and safety of high‐dose amoxicillin (AMX) and proton pump inhibitors (PPI) dual therapy raises much more attention in recent years. Comparative studies among the dual therapies are required to explore more suitable regimens. This study compared the efficacy, adverse events, and patient compliance of three different high‐dose dual regimens in treatment‐naive patients of Helicobacter pylori (H. pylori) infection.Materials and MethodsThe study was a prospective, multicenter, open‐label, randomized controlled trial, including H. pylori‐infected treatment‐naive patients at 12 tertiary hospitals in China. The eligible subjects received high‐dose AMX and esomeprazole (ESO) dual therapy of different regimens. They were randomly assigned to group A (ESO 20 mg plus AMX 750 mg, Qid for 14 days), group B (ESO 40 mg Bid plus AMX 1 g Tid for 14 days), or group C (ESO 20 mg plus AMX 1 g, Tid for 14 days). The eradication rates, adverse events, and patient compliance of the three groups were compared.ResultsBetween April 2021 and January 2022, a total of 1080 subjects were screened and 945 were randomized. The eradication rates in groups A, B, and C were 88.6% (95% CI 84.5%–91.9%), 84.4% (95% CI 80.0%–88.3%), and 86.7% (95% CI 82.4%–90.2%; p = .315), respectively, based on intention‐to‐treat analysis; 90.3% (95% CI 86.4%–93.3%), 85.5% (95% CI 81.1%–89.2%), and 87.8% (95% CI 83.6%–91.2%; p = .197), respectively, according to modified intention‐to‐treat analysis; and 90.4% (95% CI 86.5%–93.5%), 85.8% (95% CI 81.4%–89.5%), and 88.3% (95% CI 84.1%–91.7%; p = .202) in per‐protocol analysis. History of antibiotics use in 2 years reduced eradication effect in group B (ESO 40 mg Bid, AMX 1 g Tid). The modified intention‐to‐treat eradication rates were 81.4% vs 90.0% among those with or without a history of antibiotics use in group B (p = .031). The adverse event rates were 13.7%, 12.7%, and 12.1% in groups A, B, and C, respectively (p = .834). Patient compliance of the three groups was similar.ConclusionsTwo optimized AMX and PPI dual regimens (ESO 40 mg Bid or 20 mg Tid plus AMX 1 g Tid for 14 days) had similar efficacy, safety and compliance as compared with classical dual regimen (ESO 20 mg plus AMX 750 mg Qid for 14 days) in H. pylori‐infected treatment‐naive patients.
Creative Authenticity: A Framework for Supporting the Student Self in Design Education
Authors: Vernon Zachary , Paz Analee 
Published: August 2022

AbstractThis article introduces a pedagogical approach in design education referenced as creative authenticity. Creative authenticity is defined as an ongoing process of learning to create through intrinsically motivated, self‐aware and self‐affirming actions and rationales. The concept is grounded in Constructivist learning theory, Postmodernist views of pluralism and cultural position, Anthony Giddens’ theory of reflexive identities, and scholarship on intrinsic motivation in learning. This ideology seeks to personalise the learning experience for each student in ways that are meaningful to their person, not just useful to the design industry, at large. This conversation proposes four samples of methodology by which to infuse creative authenticity into curriculum as a starting point for shaking off implicit biases; focusing on student learning and growth; initiating meaningful and empowering discussions; and redefining success through collaborative and participatory educational design. This work promotes teaching with creative authenticity as a foundation to help students realise their strengths through their ever‐evolving identities. In a broader context, authenticity in education supports marginalised groups to see themselves, their histories and their experiences authentically reflected in their education and work.
Nursing representatives in clinical quality databases and the presence of nursing‐sensitive indicators of fundamental nursing care
Authors: Mainz Hanne , Odgaard Lene , Kristensen Pia Kjær 
Published: August 2022

AbstractAimTo identify and describe nursing‐sensitive indicators in Danish clinical quality databases and to examine the association between nurse representation on database steering committees and the presence of indicators related to aspects of fundamental care.DesignThis was a cross‐sectional study. The STROBE checklist was employed to ensure reporting quality.MethodsWe reviewed data from the latest annual report of 71 clinical quality databases in April 2021. Aspects of fundamental care were defined as the 12 nursing domains defined in the Danish Minimum Nursing Data framework. For each database, we recorded the number and type of indicators and identified indicators measuring fundamental care aspects. We used the prevalence ratio to estimate the likelihood of indicators related to aspects of fundamental care in databases with nurse representation on the steering committee.ResultsOne‐third of the databases included indicators related to aspects of fundamental care. The most common aspects were Respiration and circulation, Nutrition and Psychosocial conditions, whereas Skin and mucous membranes, Elimination and Pain were rarely measured. Nurse representation on the steering committee of a quality database increased the likelihood of having indicators related to aspects of fundamental care three‐fold (prevalence ratio 3.25).ConclusionFundamental care was rarely monitored in Danish clinical quality databases, but databases with nurse representation on the steering committee had a higher likelihood of monitoring fundamental care.ImpactThis study addressed the knowledge gap of how fundamental nursing care is measured in clinical quality databases. It introduces nurses to the measurement of fundamental care as a first step toward performing nursing intervention studies and investigating associations with patient outcomes. The increased likelihood of fundamental care monitoring in clinical databases with nurse representation on the steering committee indicates a feasible way for decision makers and nurse leaders to ensure a stronger focus on fundamental care to the patients' benefit.
Does the EU have friends?
Authors: Klose Stephan 
Published: August 2022

AbstractThis article seeks to explore the relevance of the concept of international friendship for the study of EU foreign policy. Drawing on a nascent friendship literature developing in the field of IR, this article argues that the EU's friendships – relations with significant others based on shared narratives and projects – play an important part in the EU's construction of its international identity. To illustrate this argument, the article provides an analysis of the EU's relations with Japan. The analysis suggests that EU‐Japan relations can usefully be described as an emergent international friendship which – revolving around the narrative of a Free and Open Indo‐Pacific and shared projects such as the EU‐Japan Partnership on Sustainable Connectivity and Quality Infrastructure – shapes and solidifies the EU's self‐image as an actor in international affairs.
Targeting SAMHD1 with hydroxyurea in first‐line cytarabine‐based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT‐AML trial
Authors: Jädersten Martin , Lilienthal Ingrid , Tsesmetzis Nikolaos , Lourda Magda , Bengtzén Sofia , Bohlin Anna , Arnroth Cornelia , Erkers Tom , Seashore‐Ludlow Brinton , Giraud Géraldine , Barkhordar Giti S. , Tao Sijia , Fogelstrand Linda , Saft Leonie , Östling Päivi , Schinazi Raymond F. , Kim Baek , Schaller Torsten , Juliusson Gunnar , Deneberg Stefan , Lehmann Sören , Rassidakis Georgios Z. , Höglund Martin , Henter Jan‐Inge , Herold Nikolas 
Published: August 2022

AbstractBackgroundTreatment of newly diagnosed acute myeloid leukaemia (AML) is based on combination chemotherapy with cytarabine (ara‐C) and anthracyclines. Five‐year overall survival is below 30%, which has partly been attributed to cytarabine resistance. Preclinical data suggest that the addition of hydroxyurea potentiates cytarabine efficacy by increasing ara‐C triphosphate (ara‐CTP) levels through targeted inhibition of SAMHD1.ObjectivesIn this phase 1 trial, we evaluated the feasibility, safety and efficacy of the addition of hydroxyurea to standard chemotherapy with cytarabine/daunorubicin in newly diagnosed AML patients.MethodsNine patients were enrolled and received at least two courses of ara‐C (1 g/m2/2 h b.i.d. d1‐5, i.e., a total of 10 g/m2 per course), hydroxyurea (1–2 g d1‐5) and daunorubicin (60 mg/m2 d1‐3). The primary endpoint was safety; secondary endpoints were complete remission rate and measurable residual disease (MRD). Additionally, pharmacokinetic studies of ara‐CTP and ex vivo drug sensitivity assays were performed.ResultsThe most common grade 3‐4 toxicity was febrile neutropenia (100%). No unexpected toxicities were observed. Pharmacokinetic analyses showed a significant increase in median ara‐CTP levels (1.5‐fold; p = 0.04) in patients receiving doses of 1 g hydroxyurea. Ex vivo, diagnostic leukaemic bone marrow blasts from study patients were significantly sensitised to ara‐C by a median factor of 2.1 (p = 0.0047). All nine patients (100%) achieved complete remission, and all eight (100%) with validated MRD measurements (flow cytometry or real‐time quantitative polymerase chain reaction [RT‐qPCR]) had an MRD level <0.1% after two cycles of chemotherapy. Treatment was well‐tolerated, and median time to neutrophil recovery >1.0 × 109/L and to platelet recovery >50 × 109/L after the start of cycle 1 was 19 days and 22 days, respectively. Six of nine patients underwent allogeneic haematopoietic stem‐cell transplantation (allo‐HSCT). With a median follow‐up of 18.0 (range 14.9–20.5) months, one patient with adverse risk not fit for HSCT experienced a relapse after 11.9 months but is now in second complete remission.ConclusionTargeted inhibition of SAMHD1 by the addition of hydroxyurea to conventional AML therapy is safe and appears efficacious within the limitations of the small phase 1 patient cohort. These results need to be corroborated in a larger study.