bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Low-Impact Aerobic Dance Exercise Video on Cardiovascular Endurance, Flexibility, and Concentration in Females With Sedentary Lifestyle
Authors: Arfanda Poppy Elisano , Wiriawan Oce , Setijono Hari , Kusnanik Nining Widyah , Muhammad Heryanto Nur , Puspodari Puspodari , Ayubi Novadri , Aprilo Ians , Arimbi Arimbi 
Published: September 2022

The study purpose was to prove the effectiveness of a low-impact aerobic dance exercise video on cardiovascular endurance, flexibility, and concentration in women with a sedentary lifestyle.
Materials and methods. This study used the Pre-Experimental method with a One-Group Pretest-Posttest Design research design. Total of 18 females aged 18–20 y.o., body mass index (BMI) 19 kg/m2 – 24 kg/m2, normal systolic and diastolic blood pressure, normal resting heart rate, oxygen saturation (SpO2) 96% – 100% participated in the research. Low-impact aerobic dance exercise was done using video for 30 minutes/exercise session with an intensity of 75% – 85% HRmax with a frequency of 3 times/week for 6 weeks. Measurement of cardiovascular endurance was done using the Multi-Stage 20-m Shuttle Run Fitness Test, flexibility was measured with the Sit and Reach Test, and concentration was meassured with the Grid Concentration Test. The statistical analysis technique used the Paired Sample T-Test with a significance level of 5%.
Results. The results showed the average cardiovascular endurance of the pretest vs. posttest (28.13 ± 4.80 vs. 30.52 ± 0.88 mL/kg/min (p ≤ 0.001)), mean flexibility of pretest vs. posttest (17.79 ± 4.72 vs. 18.75 ± 5.02 cm (p ≤ 0.001)), mean concentration of pretest vs. posttest (7.39 ± 2.38 vs. 9.11 ± 2.45 score (p ≤ 0.001)).
Conclusions. Based on the results of the study, it was concluded that a low-impact aerobic exercise dance video performed with a frequency of 3 times/week for 6 weeks increased cardiovascular endurance, flexibility, and concentration in adolescent girls with a sedentary lifestyle.
Traditional Sport Model to Improve Fundamental Movement Skills and Social Attitudes of Students During COVID-19
Authors: Mujriah Mujriah , Siswantoyo Siswantoyo , Sukoco Pamuji , Rosa Friska Octavia , Susanto Ermawan , Setiawan Edi 
Published: September 2022

The study purpose. COVID-19 caused many negative impacts, including a significant decrease in the fundamental movement skills and social attitudes among students, which becomes the main problem in this study. Therefore, this study aims to investigate the effect of traditional sport on improving students’ fundamental movement skills and social attitudes.
Materials and methods. This study adopted an experimental method with a pretest-posttest design. The subjects were elementary school students in Yogyakarta city and they were selected using random sampling (n = 30). The traditional sports program was carried out for 7 weeks with once-a-week meetings. The instrument for assessing students’ fundamental movement skills was using a gross motor development test and social attitudes were assessed using the questionnaire of Physical Education Activity Attitude. Shapiro-Wilk was used to test the normality of the data, while the Paired Sample t-test was used to assess differences in the values of students’ fundamental movement skills and social attitudes before and after the program.
Results. The results of this study indicate that traditional sports have a significant effect on improving fundamental movement skills (p < 0.05) and social attitudes (p < 0.05).
Conclusions. Thus, traditional sports programs can be used as an alternative activity that can be used by physical education teachers during the COVID-19 crisis.
Effect of Intensive Physical Loads on Plasma Testosterone and Cortisol Concentration in Elite Athletes
Authors: Maidaniuk Olena , Vdovenko Nataliia , Husarova Anna 
Published: September 2022

The study purpose was to investigate changes in the content of testosterone and cortisol in the blood of qualified athletes after testing them to determine their maximal oxygen consumption (VO2max).
Materials and methods. Thirty-seven international level athletes: 15 biathletes, 12 rowers, 6 boxers, 4 modern pentathletes participated in this study. The test to evaluate VO2max used exercise of increasing intensity on a rowing ergometer for rowers and on a treadmill for biathletes, boxers, modern pentathletes. Total testosterone and cortisol concentrations were determined in blood serum by an immunoenzyme analyzer before and after the test for determination of VO2max.
Results. The concentration of total testosterone has been found to decrease significantly on average by 24,4% and the concentration of cortisol has increased by 34% due to physical activity. The highest level of maximum oxygen consumption was found in athletes with high levels of basal testosterone and cortisol in the blood. There is a high correlation between the basal content of total testosterone and the maximum consumption of oxygen in athletes (r = 0,58).
Conclusions. The high content of basal testosterone and cortisol is an important factor for the athlete’s special working efficiency: higher level of basal cortisol has been accompanied by smaller increases in cortisol per load and high basal level of testosterone makes is possible to keep its concentration sufficient. The concentration of total testosterone and cortisol can be used as a marker of the effect of a training load.
Comparison of Ergonomic Design Approaches for Office Chairs by Accommodation Level
Authors: GÜNGÖR Celal 
Published: September 2022

Aim of study: It is very important to design office furniture based on the anthropometry of employees because it affects their comfort, performance, and in serious cases, their health. Adjustable chairs are typically designed for a certain percentile of the user population. However, this design approach may not provide an accommodation level as intended because a chair has more than one design dimension. The objective of this study is to compare the percentile-based design approach and subject-based design approach by accommodation level.
Material and methods: A sample of 4.082 males from the 2012 ANSUR II database was used to compare two design approaches by accommodation level. An adjustable office chair was designed to investigate whether or not the final accommodation level differed from the desired accommodation level. Using four anthropometric measurements, the lower and upper limits for four chair dimensions are calculated to cover 95% of users.
Main results: The anthropometric measurements of a total of 728 subjects (17.83%) did not match for at least one chair dimension, resulting in the adjustable chair accommodating 82.17% of users, rather than 95% as intended. Two additional chair dimensions (backrest height and width) reduced the accommodation level to 77.36%.
Highlights: Considering that eleven different chair dimensions are considered in a typical chair design, it is reasonable to assume that the accommodation level will be even lower.
The Relationship Between Antimicrobial Activities and Mineral Contents of Narrow Endemic Gypsophytes and Their Chemical Contents
Authors: ÖZDENİZ Ebru , AKÇA Hanife , TABAN Süleyman , GÜNEY Kerim , GÜR Mahmut , ÖZKAN Osman Emre , KESBİÇ Fevziye , KURT Latif 
Published: September 2022

Aim of study: In this study, the relationship between the antimicrobial activities and mineral contents of 7 narrow endemic gypsophyte plant species growing in extreme habitats was investigated. In addition, GC-MS analyzes of these species were also performed.
Material and methods: For this purpose, macro and micro element concentrations in soil and plant and antimicrobial activity against 13 bacteria and one yeast strain were determined by disc diffusion method in 30, 45 and 75 μL methanol and ethyl acetate extracts.
Main results: It has been presented that there is a strong antimicrobial effect potential in these gypsophyte plants. In all plant species taken, it was determined that the total Ca element among the macro elements accumulated more in the plant body than the other macro elements, and it was determined that Fe element accumulated the most among the micro elements. It was assumed that there might be a linear relationship between the strong antimicrobial activity detected in gypsophilic plant species adapted to extreme conditions and the Ca and Fe content.
Highlights: Extramophiles plants could be used in the development of antimicrobial agents in pharmaceutical industry.
Histopathological evaluation of endometrial curettings in women with abnormal uterine bleeding: A retrospective analysis
Authors: Begum Rameejan , Sheeja J 
Published: September 2022

Endometrial pathologies have been a predominate problem faced by women globally.Among all the endometrial pathologies, abnormal uterine bleeding is first in the list among the developing countries. To analyse the percentage of endometrial pathology detected in women who were diagnosed from abnormal uterine bleeding in our tertiary health care centre.A retrospective study of 158 women patients who were diagnosed with abnormal uterine bleeding and their endometrial tissue sampling were evaluated for endometrial pathology. The study data were collected from February 2017 till January 2019 based on Inclusion criteria and Exclusion criteria.According to the inclusion criteria, the 152 cases medical data which includes clinical evaluations along with endometrial histopathology evaluation were analysed. According to our analysis, the histopathological examination reports revealed most of the cases were diagnosed with benign endometrial pathology (34.72%) and abnormal endometrial pathology (9.09%). The 9.09% includes 7.44% presented with endometrial hyperplasia and 1.65% presented with endometrial cancer.Histopathological study of endometrial curettage tissue is the approved method for detecting any endometrial pathology. This is an onerous task for pathologists as not to miss any important findings. According to our analysis the commonest incidences of endometrial pathology were normal endometrium 56.19% of cases and benign pathology 34.72% and the less incidences of preneoplastic lesions 7.44% and endometrial carcinoma 1.65%.
Giant phyllodes tumor of breast with diffuse myxoid changes mimicking low- grade fibromyxoid sarcoma (LGFMS) - A case report
Authors: G.C Manasa , Singh Shilpa , Kulkarni Vardendra 
Published: September 2022

Phyllodes tumors are biphasic tumors consisting of epithelial and stromal components that account for less than 1% of all breast tumors. Phyllodes tumors are rare that behave in an unpredictable manner and can rarely have diffuse myxoid changes without an exaggerated intracanalicular pattern with leaf like fronds and stromal hypercellularity. 50-year old lady with left breast lump, morphologically mimicking low grade fibromyxoid sarcoma was finally diagnosed as recurrent phyllodes tumor (intermediate grade) with extensive myxoid change, based on the previous microscopic finding of phyllodes tumor and excluded diagnosis of low grade fibromyxoid sarcoma by MUC4 stain. Recurrent phyllodes tumor which is a common stromal tumor was diagnosed as LGFMS because of its morphology change resembling, LGFMS which was ruled later out with sensitive and specific marker for LGFMS i.e., MUC4.
Hemorrhagic stroke in children: A case report
Authors: Dukić Vuković Tanja , Miksić Mirjana , Šeruga Tomaž , Ravnik Janez 
Published: September 2022

Purpose: The purpose of this report is to present a case of hemorrhagic stroke in a child.Case report: We present a 13-year-old child with a hemorrhagic stroke, which resulted from spontaneous bleeding of congenital arteriovenous malformations in the brain.Conclusion: Although a brain stroke in children is rare, it is an important cause of disability and mortality. Clinical, neurologic, and radiologic examinations are key for the detection and treatment of arteriovenous malformations, which are the most important cause of hemorrhagic stroke in children and may threaten a child's health and life.
Konstytucyjne podstawy działalności gospodarczej państwa
Authors: Strzyczkowski Kazimierz 
Published: September 2022

Konstytucja RP nie odnosi się wprost i bezpośrednio do działalności gospodarczej państwa zarówno w aspekcie podmiotowym, jak i przedmiotowym. Uzasadnia to podjęcie próby wskazania konstytucyjnej podstawy działalności gospodarczej państwa, opierając się na derywacyjnej koncepcji interpretacji przepisów art. 20 Konstytucji RP, stanowiącego, że społeczna gospodarka rynkowa posadowiona jest na wolności działalności gospodarczej, własności prywatnej, solidarności, dialogu i współpracy partnerów społecznych; art. 22 Konstytucji RP, przewidującego, że ograniczenie wolności działalności gospodarczej jest dopuszczalne tylko w drodze ustawy i jedynie ze względu na ważny interes publiczny; oraz przepisów Konstytucji RP poświęconych w ogóle działalności gospodarczej. Za podstawę rekonstrukcji normy wyznaczającej kompetencję działalności państwa przyjęto wynikające z przepisu art. 20 Konstytucji RP „filary” ustroju społecznej gospodarki rynkowej: wolność działalności gospodarczej i własność prywatną. Wynikiem interpretacji dokonanej na bazie dyrektyw systemowych jest stwierdzenie, iż działalność gospodarcza państwa nie znajduje podstawy konstytucyjnej w zasadzie swobody działalności gospodarczej współkształtującej ustrój społecznej gospodarki rynkowej.
Bezpośredni udział państwa w obrocie gospodarczym we właściwych formach organizacyjno-prawnych jest nie tyle pochodną konstytucyjnego prawa wolnej działalności gospodarczej, ile konsekwencją odpowiednich unormowań prawnych dopuszczających powołanie przez ustawowo upoważnione organy państwa przedsiębiorców we właściwych dla działalności państwa formach organizacyjno-prawnych. Obowiązuje w tym przypadku reguła, iż nie można domniemywać kompetencji organów administracyjnych, których zakres zadań i kompetencji obejmuje stosowanie instrumentów władczej ingerencji w sferę innych osób, zgodnie z zasadą „dozwolone jest tylko to, co prawo wyraźnie przewiduje”.
Znaczenie drugiego „filaru”, to jest nakazu oparcia działalności gospodarczej na własności prywatnej, dla rekonstrukcji kompetencji działalności gospodarczej państwa w znacznym stopniu redukuje irrelewantność ustroju własnościowego podmiotów gospodarczych w przepisach prawa Unii Europejskiej (art. 345 TFUE — zasada neutralności traktatowej) i funkcjonalne podejście do kwalifikacji przedsiębiorstw jako przedsiębiorstw publicznych, w tym przedsiębiorstw państwa, co wyraźnie zmniejsza znaczenie własności prywatnej jako kryterium rozróżnienia sektora prywatnego i publicznego działalności gospodarczej.
EVALUATION OF THE PHILOSOPHY FOR CHILDREN- P4C PROGRAM APPLICATIONS APPLIED IN EDUCATIONAL INSTITUTIONS IN TURKEY ACCORDING TO TEACHER'S OPINIONS
Authors: AKAN Ramazan , BİLGİN Asude 
Published: September 2022

Yapay zekanın egemen olmaya başladığı günümüzde çocukların var olan olay, olgu ve durumlarla ilgili kavramlar geliştirirken sorgulaması ve tartışmacı bir tutum sergilemeleri çocukları anlamlı öğrenmeye taşımakta ve bilgilerin kalıcılığının sağlanmasını sağlamaktadır. Bu araştırmaya veri elde etmek amacıyla yapılan çalıştaydı Türkiye’deki eğitim kurumlarında uygulanan çocuklar için felsefe (P4C) program uygulamalarının öğretmen görüşlerine göre değerlendirilmesi amaçlanmıştır. Bu araştırmaya veri elde etmek amacıyla Eğitim kurumlarında “Çocuklar İçin Felsefe (P4C) Programı” uygulamalarına dönük yapılan çalışmaların belirlenerek ortaya çıkan açık alanlara yönelik stratejiler ile eylem ve faaliyet önerilerinin geliştirilmesi hedeflenmiştir. Bu araştırma durum deseni çalışması olup, örneklem seçiminde çoklu çeşitlilik kullanılmıştır.
Araştırma çalışma grubunu 2020-2021 eğitim öğretim yılında Türkiye’de uluslararası bir kongreye katılan farklı branşlardan oluşan gönüllü öğretmenler oluşturmaktadır. Araştırmada veriler üç gruptan oluşan, her bir grupta yer alan beş katılımcıdan oluşan toplamda on beş öğretmenin görüşleri doğrultusunda gerçekleştirilen çalıştay ile swot analizi ile bilgiler toplanmış ve alınan görüşler doğrultusunda betimsel analizi yöntemiyle çalışılmıştır. Öğretmen görüşlerinden oluşan doğrudan alıntılara yer verilmiştir. Bu araştırma konusu üzerinde öğretmenlerin yeterli düzeyde hizmet içi eğitime katılmamış olmaları, Çocuklar için Felsefe (P4C) uygulama sahası olarak alanda yeni bir yaklaşım ve uygulama çalışması olması bu bağlamda fiziki donanım ve materyal eksikliklerinin ihtiyacı karşılar nitelik ve nicelikte olmayışı, öğrenci ve öğretmenlerin sorgulamacı ve tartışmacı davranış sergilemede kendilerini ifade etmede özgür ve özgüvenli hissetmemiş olmaları yanlış anlaşılma kaygıları bu araştırmada karşılaşılan sorunlar olarak gözümüze çarpmaktadır. Buna karşın öğretmenlerin Çocuklar için felsefe yaklaşımını doğru soru sorma ve analizinin gerçekleştirilmesinin çocukta öz güven, sorgulama, yaratıcılık, eleştirel düşünme, işbirlikli ve özenli düşünme yönlerini desteklemesi nedeniyle öğrencide akademik başarı, öğretmenlerin mesleki gelişimleri açısından olumlu görüş bildirdiklerini, kendilerini geliştirme fırsatını verdiğini ve farklı bakış açısı kazandırdığını ifade etmişlerdir.
Interference Patterns Within a Circular Boundary
Authors: Korula Aswan 
Published: September 2022

Abstract
In this paper we conduct a simple experiment wherein we create a wave within a circular container and analyse the interference patterns generated by the reflections from the boundary. In doing so we observe constructive interference in positions where our current wave theory predicts noise. This peculiar result demonstrates that in the particular situation presented here, the velocities of a wave before and after reflection from a solid boundary, are unequal.
Inhibitory effect of TCF7L2 on pancreatic β-cell dedifferentiation via ERK/MAPK signaling pathway in diabetes
Authors: Wu Hui-Hui , Ma Qian-Wen , Liu Yi-Meng , Wu Xia , Wang Xuan-Chun , Lu Bin , Zhang Zhao-Yun , Wen Jie 
Published: September 2022

Abstract
Background
Transcription factor 7-like 2 (TCF7L2) variants seem to affect diabetes susceptibility through β-cell dysfunction, underlying basis of which has been considered to be β-cell dedifferentiation rather than apoptotic β-cell death. However，little is known about how TCF7L2 variation contributes to β-cell dedifferentiation and how pancreatic β-cell dedifferentiation changes during diabetes progression.
Methods
To clarify the effects of TCF7L2 on β-cell dedifferentiation and insulin secretion, MIN6 cells were transfected with TCF7L2 shRNA or lenti-TCF7L2 virus for 48h and then the degree of β-cells dedifferentiation and insulin concentrations in supernatant were measured respectively. To further determine whether the effects are mediated by ERK/MAPK signal pathway, MIN6 cells were administrated with ERK phosphorylation inhibitor U0126 prior to TCF7L2 shRNA virus transfection. Subsequently, changes of TCF7L2 expression and pancreatic β-cell dedifferentiation were measured respectively in db/db mice after 2, 6 and 10 weeks of ND or HFD feeding.
Results
Our present study demonstrated that stable shRNA-mediated knockdown of TCF7L2 significantly increased β-cell dedifferentiation and drastically decreased insulin secretion of MIN6 cells. The opposite results were observed following lenti-TCF7L2 virus transfection. Interestingly, TCF7L2 exerted an inhibitory effect on the activation of ERK/MAPK signal and the effects of TCF7L2 on β-cells dedifferentiation and insulin secretion were totally attenuated when the phosphorylation of ERK was blocked using its chemical inhibitor U0126. Additionally, the declined TCF7L2 expression in paralleled with sustained activation of ERK/MAPK signal and increased pancreatic β-cell dedifferentiation were observed simultaneously in db/db mice. All animals showed impaired glucose tolerance during intraperitoneal glucose tolerance tests.
Conclusion
The pancreatic β-cell dedifferentiation which mediated by ERK/MAPK signaling pathway might be the essential component of TCF7L2 variants to develop diabetes.
Enhancing Consumption of Sustainable Transportation: Determinants and Outcome of Consumer Engagement with Bike-Sharing Service
Authors: Waqas Muhammad , Najmi Arsalan 
Published: September 2022

Abstract
Bike-sharing service has become a popular sustainable means of transportation due to its direct impact on traffic congestion, energy consumption, the environment, and people’s quality of life. Existing literature suggests that sustainable consumption can be promoted by engaging consumers with green products. This study examined drivers and the outcome of consumer engagement with bike-sharing services based on the technology acceptance model (TAM). A survey was conducted to collect the data from the users of the bike-sharing service in Kuala Lumpur. Structural equation modelling was used to analyse the data and find the relationship between variables. The empirical analyses showed that perceived ease of use and perceived usefulness of the bike-sharing service positively impact all facets of consumer engagement with bike-sharing service, which subsequently influences the continuance usage intention of bike-sharing service. The findings of this study offer useful insights that could enhance the consumption of bike-sharing service. This study also offers some guidelines to transportation practitioners, policymakers, and urban planners regarding promoting healthy and sustainable travel behaviour among urban commuters through bike-sharing service.
m7G-related miRNA signature for prediction of prognosis in lung adenocarcinoma
Authors: Jiang Sujing , Shi YueLi , Xiao Mingshu , Wang Yongfang , Xu Zhiyong , Wang Kai 
Published: September 2022

Abstract
Background
N7-methylguanosine (m7G), one of the most conserved nucleotide modifications, presents in mRNA caps and internal sites of tRNAs and rRNAs. Previous data have demonstrated that abnormal m7G is associated with tumorigenesis. Notably, the expression of m7G’s regulators remains unknown in human cancers, especially in lung adenocarcinoma (LUAD). This study aimed to construct a prognostic signature based on m7G-related miRNAs in LUAD and to explore the potential association of the regulators with tumor immune microenvironment (TIME).
Methods
We used LUAD data from The Cancer Genome Atlas (TCGA) to establish a risk model based on the m7G-related miRNAs, and divided patients into high-risk or low-risk subgroups. A nomogram for predicting overall survival (OS) was then constructed based on the independent risk factors. In addition, we performed functional enrichment analysis and defined the immune landscape as well as drug response profile in the high-risk and low-risk subgroups.
Results
This study incorporated 28 m7G-related miRNAs into the risk model. The data showed a significant difference in the OS between the high-risk and low-risk subgroups. The receiver operating characteristic curve (ROC) predicted that the area under the curve (AUC) of 1-year, 3-year and 5-year OS was 0.781, 0.804 and 0.853, respectively. The C-index of the prognostic nomogram for predicting OS was 0.739. We then analyzed the immune landscape in the high-risk and low-risk subgroups. The data demonstrated significant differences in the estimated score, immune score, stromal score, immune cell infiltration and functions between the high-risk and low-risk subgroups. In addition, drug response analysis showed that low-risk subgroups may be more sensitive to tyrosine kinase inhibitor (TKI) and histone deacetylase (HDAC) inhibitors.
Conclusion
We successfully developed a novel risk model based on m7G-related miRNAs in this study. The model can predict clinical prognosis and guide therapeutic regimens in patients with LUAD. Our data also provided new insights into molecular mechanisms of m7G in LUAD.