bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different assessment tools to detect sarcopenia in patients with Parkinson's disease
Authors: Valent Dora , Peball Marina , Krismer Florian , Lanbach Anna , Zemann Sophie , Horlings Corinne , Poewe Werner , Seppi Klaus 
Published: November 2022

IntroductionSarcopenia and Parkinson's disease are closely related diseases of the elderly population leading to progressive disability and nursing-dependent care.ObjectiveThe aim of this study was to estimate the prevalence of sarcopenia in PD patients with three different approaches: (1) the screening tool SARC-F, (2) EWGSOP-1 criteria, and (3) EWGSOP-2 criteria. Moreover, we aimed to evaluate the diagnostic accuracy of the screening tool SARC-F to detect sarcopenia according to the updated EWGSOP-2 criteria.MethodsEighty-one patients with Parkinson's disease aged 65 years and above were interviewed in a cross-sectional study at a tertiary referral center. All patients were screened with the SARC-F questionnaire and were evaluated for motor and non-motor symptoms, exercise, quality of life, and frailty. Muscle mass was assessed with bioelectrical impedance analysis, handgrip strength with a dynamometer, and gait speed was assessed with the 8-m walk test. EWGSOP-2 criteria were considered the gold standard to diagnose sarcopenia in our study.ResultsEighty-one patients were evaluated (mean age: 73.82; SD 5.30). The prevalence of sarcopenia was 28.4% according to the EWGSOP-2 criteria. The concordance between EWGSOP-2 and EWGSOP-1 was poor (weighted kappa of 0.361[95% 0.164–0.557]). The sensitivity of the SARC-F screening test for detecting sarcopenia was 60.9%. The corresponding AUC in the ROC curve analysis showed 0.598 (0.462, 0.734 CI). The item assessing strength was found to have the highest sensitivity (69.6%).ConclusionSarcopenia prevalence in patients with PD in Tirol, Austria is higher with EWGSOP-1 criteria compared to EWGSOP-2 criteria. The sensitivity and specificity of the SARC-F scale to detect sarcopenia in this population are poor.
Sleep disturbance has the largest impact on children's behavior and emotions
Authors: Matsuoka Michiko , Matsuishi Toyojiro , Nagamitsu Shinichiro , Iwasaki Mizue , Iemura Akiko , Obara Hitoshi , Yamashita Yushiro , Maeda Masaharu , Kakuma Tatsuyuki , Uchimura Naohisa 
Published: November 2022

ObjectiveChildren's behavior and emotions are affected by sleep disturbances, the parent-child relationship, media viewing time, and the social status of parents and caregivers. We conducted a questionnaire survey to identify the factors that have the greatest impact on children's behavior and emotions and how these factors relate to each other.MethodsA parental questionnaire survey was performed at a public elementary school. The questionnaire comprised questions on the family environment (e.g., family structure, media and game exposure, after-school lessons, and caregiver's work schedule) and physical information, the Strengths and Difficulties Questionnaire (SDQ), the Children's Sleep Habits Questionnaire (CSHQ), and the Pittsburgh Sleep Quality Index (PSQI) for parents' sleep condition. A path diagram was drawn to hypothesize the complex interrelationships among factors, and structural equation modeling was used to estimate the path coefficients.ResultWe identified several factors that significantly affected the SDQ score. The CSHQ total score had the largest impact, followed by after-school lessons, single-mother families, and children's sex. In addition, several indirect pathways that led to the CSHQ score (i.e., a pathway from time spent watching television to CSHQ score via children's bedtime and a pathway from single-mother family to CSHQ score via PSQI total score) significantly affected the SDQ score.ConclusionChildren's sleep habits that were influenced by several environmental factors had the greatest impact on children's behavior and emotions, which suggested that children's behavioral problems can be improved by interventions focused on sleep habits, such as sleep hygiene instructions.
Chronic effects of different exercise types on brain activity in healthy older adults and those with Parkinson’s disease: A systematic review
Authors: Wang Leilei , Li Feiyue , Tang Lu 
Published: November 2022

Objective: This study aimed to compare the regulation of brain activity by different kinds of long-term exercises (Tai Chi, treadmill training, and dancing) in healthy older adults and those with PD.Methods: From January 2000 to October 2021, the electronic databases PubMed, Web of Science, and Scopus were searched. All articles were screened throughout the inclusion and exclusion criteria, which was followed by PICOS criteria. Finally, all articles were systematically reviewed with analyses.Results: 29 studies were identified for this review, 24 of which were finally included in a group of healthy older adults, and five of which in a group of people with PD. All studies showed that significant changes were showed on people with PD and healthy older adults’ brain activity after three terms of the exercises we chose. An inverse change trend on the functional connectivity in people with PD was observed after treadmill training, whereas increased brain activity, cognitive function, memory, and emotion were noticed in healthy older adults.Conclusion: Our findings suggest that different patterns of brain activity were also observed between healthy older adults and people with PD after treadmill training. However, more robust evidence and comprehensive studies are needed to determine if there is a difference between healthy older adults and people with PD.
Psychosocial safety climate (PSC) at middle management level in the healthcare sector: A contribution to the Italian validation of psychosocial safety climate-4
Authors: Fattori Alice , Comotti Anna , Bordini Lorenzo , Dollard Maureen F. , Bonzini Matteo 
Published: November 2022

IntroductionPsychosocial safety climate (PSC) refers to workers’ shared perceptions of organizational policies, practices and procedures for the protection of psychological health and safety. PSC offers a multilevel organizational approach that expands traditional models of workplace stress, giving a more comprehensive understanding of occupational health and safety issues. Although considerable research on psychosocial risks in the healthcare sector has been conducted, few studies have explored the role of PSC among healthcare workers at middle management level. Additionally, no validated version of PSC is available in Italian language. The aim of this study is to contribute to the validation of the Italian 4-item version of the PSC and to explore this theory within the Job Demands-Resources model (JD-R) among a sample of Italian healthcare workers by testing PSC at the middle management level.MethodsWe used cross-sectional data from 276 employees working in 17 different wards in a large Italian hospital. Intra-class coefficient (ICC) coefficient and agreement index were used to test PSC as a climate construct (data nested to hospital ward level). We performed hierarchical linear models to test mediation and moderation effects.ResultsThe Italian version of PSC-4 proved to have good psychometric properties and confirmed its role as a group-level construct (α = 0.84; ICC = 0.16). Multilevel random coefficient models showed PSC was associated with Job demands (Effort: B = −0.36, SE = 0.07; Emotional demands: B = −0.03, SE = 0.01) and Job resources (Reward: B = 1.16, SE = 0.01; Physical work environment: B = 0.06, SE = 0.01). Results confirmed the indirect effect of PSC on Psychological (Burnout) and Occupational health (Job satisfaction) outcomes supporting the role of Job resources and Job demands as mediators. The multilevel analysis did not find a significant interaction terms between PSC and Job demands on Burnout therefore the moderation hypothesis was not supported.DiscussionThe Italian version of PSC-4 is a valid tool to evaluate PSC. These findings sustain the multilevel framework of PSC and the significant role played by mid-leaders in both the health impairment and motivational path. Further studies should explore the buffering effect of PSC at higher baseline levels as well as the adoption of PSC as a target for occupational health intervention the Italian context.
Methodological heterogeneity biases physical activity metrics derived from the Actigraph GT3X in multiple sclerosis: A rapid review and comparative study
Authors: Polhemus Ashley , Haag Christina , Sieber Chloé , Sylvester Ramona , Kool Jan , Gonzenbach Roman , von Wyl Viktor 
Published: November 2022

BackgroundPhysical activity (PA) is reduced in persons with multiple sclerosis (MS), though it is known to aid in symptom and fatigue management. Methods for measuring PA are diverse and the impact of this heterogeneity on study outcomes is unclear. We aimed to clarify this impact by comparing common methods for deriving PA metrics in MS populations.MethodsFirst, a rapid review of existing literature identified methods for calculating PA in studies which used the Actigraph GT3X in populations with MS. We then compared methods in a prospective study on 42 persons with MS [EDSS 4.5 (3.5–6)] during a voluntary course of inpatient neurorehabilitation. Mixed-effects linear regression identified methodological factors which influenced PA measurements. Non-parametric hypothesis tests, correlations, and agreement statistics assessed overall and pairwise differences between methods.ResultsIn the rapid review, searches identified 421 unique records. Sixty-nine records representing 51 eligible studies exhibited substantial heterogeneity in methodology and reporting practices. In a subsequent comparative study, multiple methods for deriving six PA metrics (step count, activity counts, total time in PA, sedentary time, time in light PA, time in moderate to vigorous PA), were identified and directly compared. All metrics were sensitive to methodological factors such as the selected preprocessing filter, data source (vertical vs. vector magnitude counts), and cutpoint. Additionally, sedentary time was sensitive to wear time definitions. Pairwise correlation and agreement between methods varied from weak (minimum correlation: 0.15, minimum agreement: 0.03) to perfect (maximum correlation: 1.00, maximum agreement: 1.00). Methodological factors biased both point estimates of PA and correlations between PA and clinical assessments.ConclusionsMethodological heterogeneity of existing literature is high, and this heterogeneity may confound studies which use the Actigraph GT3X. Step counts were highly sensitive to the filter used to process raw accelerometer data. Sedentary time was particularly sensitive to methodology, and we recommend using total time in PA instead. Several, though not all, methods for deriving light PA and moderate to vigorous PA yielded nearly identical results. PA metrics based on vertical axis counts tended to outperform those based on vector magnitude counts. Additional research is needed to establish the relative validity of existing methods.
Expression of matrix metalloproteinases (MMPs)−2/-7/-9/-14 and tissue inhibitors of MMPs (TIMPs)−1/-2 in bovine cutaneous fibropapillomas associated with BPV-2 infection
Authors: Daraban Bocaneti Florentina , Altamura Gennaro , Corteggio Annunziata , Tanase Oana Irina , Dascalu Mihaela Anca , Pasca Sorin Aurelian , Hritcu Ozana , Mares Mihai , Borzacchiello Giuseppe 
Published: November 2022

IntroductionBovine papillomaviruses −1/−2 (BPVs) are small non-enveloped double-stranded DNA viruses able to infect the skin of bovids and equids, causing development of neoplastic lesions such as bovine cutaneous fibropapillomas and equine sarcoid. Matrix metalloproteinases (MMPs) are a group of zinc-dependent endopeptidases that degrade basal membrane and extracellular matrix, whose function is essential in physiological processes such as tissue remodeling and wound healing. MMPs activity is finely regulated by a balancing with expression of tissue inhibitors of MMPs (TIMPs), a process that is impaired during tumour development. BPV infection is associated with upregulation of MMPs and /or their unbalancing with TIMPs, contributing to local invasion and impairment of extracellular matrix remodeling in equine sarcoid; however, studies regarding this topic in bovine fibropapillomas are lacking.MethodsThe aim of this study was to perform an immunohistochemical and biochemical analysis on a panel of MMPs and TIMPs in BPV-2 positive bovine cutaneous fibropapillomas vs. normal skin samples.ResultsImmunohistochemistry revealed a cytoplasmic expression of MMP-2 (15/19), a cytoplasmic and perinuclear immunoreactivity of MMP-7 (19/19) and MMP-9 (19/19), along with a cytoplasmic and nuclear pattern of MMP-14 (16/19), accompanied by a cytoplasmic expression of TIMP-1 (14/19) and TIMP-2 (18/19) in tumour samples; western blotting revealed an overexpression of MMP-2 (8/9), MMP-7 (9/9) and MMP-9 (9/9), and a decreased level of MMP-14 (9/9), TIMP-1 (9/9) and TIMP-2 (9/9) in tumour versus normal skin samples. Moreover, gelatine zymography confirmed the expression of pro-active MMP-2 (9/9) and MMP-9 (9/9) and, most importantly, indicated the presence and increased activity of their active forms (82 and 62 kDa, respectively) in tumour samples.DiscussionThis is the first study describing MMPs and TIMPs in bovine cutaneous fibropapillomas and our results suggest that their unbalanced expression in presence of BPV-2 may play a significant role in tumour development. A further analysis of supplementary MMPs and TIMPs could bring new important insights into the papillomavirus induced tumours.
Parental Genetics Communicate with Intrauterine Environment to Reprogram Newborn Telomeres and Immunity
Authors: Farrukh Sadia , Baig Saeeda , Hussain Rubina , Imad Rehan , Khalid Maria 
Published: November 2022

Telomeres, markers for cellular senescence, have been found substantially influenced by parental inheritance. It is well known that genomic stability is preserved by the DNA repair mechanism through telomerase. This study aimed to determine the association between parents–newborn telomere length (TL) and telomerase gene (TERT), highlighting DNA repair combined with TL/TERT polymorphism and immunosenescence of the triad. The mother–father–newborn triad blood samples (n = 312) were collected from Ziauddin Hospitals, Pakistan, between September 2021 and June 2022. The telomere length (T/S ratio) was quantified by qPCR, polymorphism was identified by Sanger sequencing, and immunosenescence by flow cytometry. The linear regression was applied to TL and gene association. The newborns had longest TL (2.51 ± 2.87) and strong positive association (R = 0.25, p ≤ 0.0001) (transgenerational health effects) with mothers’ TL (1.6 ± 2.00). Maternal demographics—socioeconomic status, education, and occupation—showed significant effects on TL of newborns (p < 0.015, 0.034, 0.04, respectively). The TERT risk genotype CC (rs2736100) was predominant in the triad (0.6, 0.5, 0.65, respectively) with a strong positive association with newborn TL (β = 2.91, <0.0011). Further analysis highlighted the expression of KLRG 1+ in T-cells with shorter TL but less frequent among newborns. The study concludes that TERT, parental TL, antenatal maternal health, and immunity have a significantly positive effect on the repair of newborn TL.
Exposure to Nanoplastic Particles Enhances Acinetobacter Survival, Biofilm Formation, and Serum Resistance
Authors: Tang Mingfeng , Ding Guoying , Lu Xiaoyu , Huang Qian , Du Huihui , Xiao Guosheng , Wang Dayong 
Published: November 2022

The interaction between nanoplastics and bacteria remains still largely unclear. In this study, we determined the effect of nanopolystyrene particle (NP) on a bacterial pathogen of Acinetobacter johnsonii AC15. Scanning electron microscopy (SEM) analysis indicated the aggregation of NPs from 10 μg/L to 100 μg/L on surface of A. johnsonii AC15, suggesting that A. johnsonii AC15 acted as the vector for NPs. Exposure to 100–1000 μg/L NPs increased the growth and colony-forming unit (CFU) of A. johnsonii AC15. In addition, exposure to 100–1000 μg/L NPs enhanced the amount of formed biofilm of A. johnsonii AC15. Alterations in expressions of 3 survival-related (zigA, basD, and zur), 5 biofilm formation-related (ompA, bap, adeG, csuC, and csuD), and 3 serum resistance-related virulence genes (lpxC, lpxL, and pbpG) were observed after exposure to 1000 μg/L NPs. Moreover, both CFU and survival rate of A. johnsonii AC15 in normal human serum (NHS) were significantly increased by 1–1000 μg/L NPs, suggesting the enhancement in serum resistance of Acinetobacter pathogen by NPs. In the NHS, expressions of 3 survival-related (zigA, basD, and zur), 9 biofilm formation-related (ompA, bap, adeF, adeG, csuA/B, csuC, csuD, csuE, and hlyD), and 3 serum resistance-related virulence genes (lpxC, lpxL, and pbpG) were affected by 1000 μg/L NPs. Expressions of 1 survival-related (zigA), 5 biofilm formation-related (bap, adeG, csuC, csuD, and csuE), and 3 serum resistance-related virulence genes (lpxC, lpxL, and pbpG) were also altered by 10 μg/L NPs after the addition of NHS. Therefore, exposure to NPs in the range of μg/L has the potential to enhance bacterial virulence by increasing their growth, biofilm formation, and serum resistance.
Efeito da aromaterapia por inalação sobre a ansiedade em adultos: uma revisão sistemática
Authors: Leite Moreira Alan , Dantas Raysa Matias , Trajano Flávia Maiele Pedroza , Braga João Euclides Fernandes , Galvão Vivianny Kelly 
Published: November 2022

Introdução. A ansiedade é um dos transtornos mentais que mais acomete a população mundial e a aromaterapia tem se destacado como uma terapia para o seu controle. Objetivo. Identificar os ensaios clínicos realizados com aromaterapia por inalação e discutir seu efeito sobre a ansiedade em adultos. Método. Trata-se de uma revisão sistemática, de caráter exploratório e abordagem descritiva, a partir das bases de dados LILACS, SCIELO e PubMed. Utilizou-se os descritores “aromaterapia”, “óleos essenciais” e “ansiedade” para busca no título e no resumo dos artigos. Incluiu-se apenas ensaios clínicos com pertinência quanto à pergunta de pesquisa deste estudo. Resultados. Analisou-se quatorze artigos publicados entre os anos de 2000 e 2020, com amostra dos estudos variando entre 17 e 361 participantes. Identificou-se que 78,57% das pesquisas foram transversais e realizadas com pacientes em procedimentos e atendimentos médico ou odontológico, sendo 64,29% desenvolvidas no continente Asiático. Também se verificou que 57,14% dos estudos utilizaram o Inventário de Ansiedade Traço e Estado (IDATE) como método para avaliação da ansiedade e em 57,14% usaram o óleo essencial de Lavanda, sendo inalado em 64,28% com o auxílio de algodão/gaze ou de máscara e em sessões entre 5 minutos e 15 minutos. Além disso, 71,43% das investigações indicaram redução significante da ansiedade. Conclusão. Apesar da divergência de algumas pesquisas, a aromaterapia por inalação controla os níveis de ansiedade em adultos, podendo ser indicada como terapia complementar neste público.
Estimasi Potensi Cadangan Air Tanah Dengan Metode Persamaan Darcy di Desa Pilomonu, Gorontalo
Authors: Sugianti Komang , Zainuri Ahmad , Hutagalung Ronal 
Published: November 2022

This research aims to know the prediction of potential for groundwater reserves. The research method applies surface geological mapping and subsurface data collection with the 200-span Schlumberger configuration geoelectric method. The stratigraphy of the research area is sorted from old to young, the first is the granodiorite unit, the sandstone unit, and alluvial units are deposited inconsistently. The geological structure working in the research area has a dominant northwest-southeast direction. The direction of. groundwater flow follows the topography of the research area, whicb is flowing from the north to the south, where the elevation of the norlh js higher than the eJevation of the south. The aquifer characteristics in the research area can be divided into two based on the mterpretation of geoelectric inversion, such as shallow aquifer with material in the form of sand and deep aquifer with sand and gravel material. Prediction of the potential for groundwater reserves is obtained from the interpretation of geoelectric data and data from the calculation of the groundwater level in the research area by observing the. conditions around the research area So, it is obtained a prediction of potential for shallow groundwater reserves is 360.444 m3/day or equivalent to 360,444 liters/day, and the prediction of poteptial deep groundwater reserves is 66,520.476 m3/day or equivalent to 66:,520,476 liters/day.
New Self-Isolated MIMO Antenna Array for 5G mm-Wave Applications
Authors: Sokunbi Oludayo , Attia Hussein , Hamza Abubakar , Shamim Atif , Yu Yiyang , Kishk Ahmed 
Published: November 2022

<p>In this paper, a simple novel technique to self-isolate multiple-input-multiple-output (MIMO) antenna array elements for mm-wave applications is proposed. MIMO antenna arrays with inter-element separation of 0.2 mm (0.023λ at 35 GHz) and measured high isolation (>50 dB) are presented. Several rigorously optimized slots of different shapes, positions, and dimensions are etched on the radiating patch to enhance the inter-element isolation within 28-37.5 GHz impedance bandwidth.<br>
The surface current distributions, parametric analysis, and two MIMO array configurations are employed to validate the proposed self-isolation technique. The novel mm-wave antenna exhibits high impedance bandwidth (>29%), high isolation (>50dB), high efficiency (>90%), high gain (>9.5 dB), and low envelope correlation coefficient (<0.005) throughout the desired bandwidth.<br>
Two configurations of the MIMO antenna arrays are fabricated and measured to validate the simulation outcomes. To the best of the authors’ knowledge, the presented design is the first to exhibit such wideband isolation improvement without any external decoupling structure at the mm-wave frequency range.<br>
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MICROTERRITÓRIOS E SEGREGAÇÃO NO ESPAÇO PÚBLICO DA CIDADE CONTEMPORÂNEA
Authors: Serpa Angelo 
Published: November 2022

Neste artigo são discutidas as relações entre microterritorialidades urbanas e as estratégias de apropriação socioespacial do espaço público na cidade contemporânea, com o intuito de explicitar os conteúdos simbólicos e de cunho segregacionista que se manifestam através da constituição de territórios plásticos e móveis dos diferentes grupos sociais, classes e frações de classe. Essas questões são analisadas a partir de exemplos concretos em Paris e Salvador, que revelam os efeitos de classe (segmentação) e de massa (transversalidade) nos processos de apropriação de praias e parques em um contexto urbano/metropolitano. A operacionalização dos conceitos de território e espaço público na análise dos exemplos apresentados mostra, por outro lado, que as barreiras/os limites que se estabelecem entre os diferentes territórios resultam de uma dialética entre capital cultural e econômico que vai condicionar processos de segmentação/segregação no espaço público da cidade contemporânea, desvendando “identidades” baseadas nos modos de consumo do/no espaço.