bluuebunny/crossref_metadata_2025_split huggingface dataset:
A real-world pharmacovigilance study of FDA Adverse Event Reporting System (FAERS) events for Osimertinib
Authors: Yin Yanchao , Shu Yamin , Zhu Junru , Li Feie , Li Juan 
Published: August 2022

Abstract
Background
Osimertinib was a third-generation, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), which approved by the US Food and Drug Administration (FDA) in 2015 for treatment of non-small cell lung cancer (NSCLC). Our study was to explore the adverse events (AEs) caused by osimertinib through data mining of the US FDA Adverse Event Reporting System (FAERS), and provide reference for clinical safety.
Methods
Data of osimertinib were collected from the FAERS database covering the period from first quarter of 2016 to the fourth quarter of 2021. Disproportionality analyses was employed to quantify the associated AE signals of osimertinib and detect the risk signals from the data in the FAERS database. ROR was used to detect the risk signals from the data in the FAERS database. The definition relied on system organ class (SOCs) and preferred terms (PTs) by the Medical Dictionary for Regulatory Activities (MedDRA).
Results
Totally, 9704338 reports were collected from the FAERS database, 10804 reports of osimertinib were identified as the ‘primary suspected (PS)’ AEs. Osimertinib induced AEs occurred in 27 organ systems. 68 significant disproportionality PTs satisfying with the four algorithms were retained at the same time. Unexpected significant AEs such as scrotal volvulus, hepatic function abnormal, VTEs might also occur. The median onset time of osimertinib-associated AEs was 58 days (interquartile range [IQR] 14–212 days), and the majority of the AEs occurred within the first 30 days after osimertinib initiation.
Conclusion
Our study found significant new AEs signals of osimertinib and might provide support for clinical monitoring and risk identification of osimertinib.
Effect of Zn(II) on pramlintide: structural kink, fibril formation, antifungal activity
Authors: Dudek Dorota , Dzien Emilia , Watly Joanna , Matera-Witkiewicz Agnieszka , Mikolajczyk Aleksandra , Hajda Agata , Olesiak-Banska Joanna , Rowinska-Zyrek Magdalena 
Published: August 2022

Abstract
The antimicrobial properties of amylin, a polypeptide secreted by the pancreas, are far less known than its antidiabetic function. Among the studied amylin analogues, the coordination of zinc(II) enhances the antifungal properties of pramlintide, a non-fibrillating therapeutic analogue of amylin; binding at the N-terminal amino group and His18 imidazole, it induces a kink in the peptide structure, which, in turn, triggers a fibrillization process of the complex, resulting in an amyloid structure most likely responsible for the disruption of the fungal cell.
A Novel HVgP and OLBP approach in Distributed Transaction Partitioning
Authors: R.D.Bharati R.D.Bharati , V.Z.Attar V.Z.Attar 
Published: August 2022

Abstract
Data partitioning acts an important role in Online Transaction Processing (OLTP) to enhance their performance and scalability. Partitioning is important in OLTP based systems due to the increase of user populations and online transactions. Nowadays, providing scalable and reliable data organization is the main aim of database researchers. This work presented an innovative data partitioning approach and optimized load balancing for scalable transactions. Initially, the Hybrid Vertical-graph partitioning (HVgP) approach is utilized for appropriate data partitioning. After the process of data partitioning, the partitions efficiency and the average workload parameters are computed and their corresponding weight factor is computed. Subsequently, Optimized Improved Load Balancing (OLBP) algorithm is utilized for scalable OLTP data transactions on distributed database. Here, the estimated weight factor is updated for effective load balancing with data partitions. The presented approach is appropriate for various online data transaction applications. The quality of the presented approach is examined using TPC-E OLTP benchmark dataset. The performance of the improved approach is examined with the different existing approaches and proved the significant enhancement in different performance metrics like Throughput, Response time, distributed transactions, and CPU utilization.
Parallel Social Group Optimization (Psgo): Performance and Its Application to Routing in Wmn’s
Authors: Sharma Bhanu , Singh Amar 
Published: August 2022

Abstract
This paper proposes a new multi-population-based social optimization technique called Parallel Social Group Optimization (PSGO). The algorithm is inspired by the learning behaviour of humans in different groups. In this algorithm, we consider the complete process of human interaction within the group and outside the group. We implement the proposed algorithm in MATLAB and tested it on 30 standard benchmark functions. For performance analysis purposes, we compare the PSGO algorithm with other recent 16 algorithms. The PSGO algorithm outperformed the other 16 algorithms on 4 standard benchmark functions. None of the other algorithms could match this performance. In addition, for functions f1,f2, f3,f4,f5, and f7of standard benchmark functions it produced the best performance but this performance was equalled by a few other algorithms also. Further, we propose a PSGO-based dynamic route evaluation approach for Wireless Mesh Networks (WMNs). We implemented the PSGO-based routing approach in MATLAB and compared it with 9 soft computing and hard computing-based approaches namely AODV, DSR, ACO, BBO, BAT, Firefly, BBBC, GA, and SGO. On over 1500 dynamic node network situations, the PSGO-based routing technique outscored all other 9 algorithms.
The Effect of Coriander Oil Addition to Goat Feed on the Technological Properties of the Resultant Milk; Rayeb as a Product Model
Authors: Abd-Rabou Hagar S. , Mahmoud Hanem M. , Matloup O. H. , Sallam S. M. , Elazab M.A. 
Published: August 2022

Abstract
Goat milk is an essential alternative milk resource for those suffering from cow and buffalo milk allergies and is considered a nutrient protein source for children and neonates. This paper aims to answer the question: Does adding crude coriander oil to goats' food affect the quality of their milk and the properties of their products? Study the chemical, rheological, and microbiological properties and the acceptability of probiotic goat's rayeb milk. Two coriander oil concentrations were used in the study; a low level of 0.95% (T1) and a high level of 1.9% (T2). The results declared that coriander oil did not affect the coagulation time, which was almost six hours for all batches. At the same time, the apparent viscosity decreased significantly (p ≤ 0.05) in T2 with the high oil level. Moreover, treatments showed a significant (p ≤ 0.05) increase in the content of monounsaturated fatty acids and a decrease in polyunsaturated fatty acids. Low-level oil supplementation showed the best rayeb properties, surpassing the control treatment in most properties and higher sensory scores.
First documented case of thrombolysis in a teaching hospital in Ghana: challenges to early intervention in acute infarctive stroke in developing countries
Authors: Duodu F. , Pekyi-Boateng Prince , Agbinko-Djobalar Babbel , Mends David Brodie , Nkromah Kodwo , Adjei Patrick , Akpalu Albert 
Published: August 2022

Abstract
Background
We report a case of an elderly woman who developed an Ischemic stroke. Thrombolytic therapy was successful as evidenced by functional and neurological improvement. This is the first well-documented case of such intervention in Korle-Bu Teaching Hospital (KBTH), Stroke unit.
Case Information:
Our patient is a 64-year-old woman who is known to have hypertension and diabetes. She had been relatively well until she developed an ischemic stroke. Five days prior to this, she had experienced two episodes of Transient Ischemic Attacks (TIA). Thrombolytic therapy was successful with Tenecteplase given at 4.5 hours post-episode. MRS (Modified Ranking Scale) and NHISS (National Health Institute of Stroke Scale) pre thrombolysis were 4 and 10 respectively. NHISS 2hrs post thrombolysis was 4. MRS and NHISS 24hrs post thrombolysis were 0 and 1 respectively. We sought to identify why only a few cases of thrombolytic therapies are carried out in developing countries, and we found that the strict eligibility for the initiation of therapy was the main barrier.
Conclusion
In acute infarctive stroke management, intervention is time-dependent, as thrombolysis has been shown to prevent permanent disability if instituted early enough. We believe that many more individuals may benefit from thrombolytic therapy if more studies are carried out with systematic reviews of case reports and research, factoring in key challenges met in middle to low-income countries.
Orthostatic hypotension is associated with malnutrition diagnosed by GLIM in elderly hypertensive patients
Authors: Zhang Qizhe , Shen Shanshan , Guan Huilan , Zhang Jingmei , Chen Xujiao 
Published: August 2022

Abstract
Background:Orthostatic Hypotension (OH) and malnutrition, are common health problems in elderly hypertensive patients. This study aimed to analyze the relationship between malnutrition and OH in elderly hypertensive patients. Methods:This is a cross-sectional single-center study. All participants underwent a Comprehensive Geriatric Assessment (CGA), in which malnutrition was defined according to the Global Leadership Initiative on Malnutrition (GLIM) criteria based on four different methods of diagnosing muscle mass loss. Furthermore, the accuracy of these methods was verified by Receiver Operating Characteristic (ROC) analysis. Univariate and multivariate logistic regression analyses were used to identify risk factors for OH in elderly hypertensive patients. Results: For GLIM criteria, when Fat-Free Mass Index (FFMI) was the gold standard for muscle mass loss, the Area Under ROC Curve (AUC) values for Upper Arm Circumference (UAC), Calf Circumference (CC), and Hand Grip Strength (HGS) were 0.784, 0.805, and 0.832, with moderate accuracy in diagnosing malnutrition. Multivariate analysis showed that females, Diabetes Mellitus (DM), diuretics, and malnutrition diagnosed by GLIM-UAC were risk factors for OH in elderly hypertensive patients. Conclusions: Prompt detection of malnutrition in the elderly and attention to changes in UAC may be critical. Similarly, we should strengthen medication and disease management in elderly hypertensive patients.
On the Political Economy of Conflicts in the Middle East and Africa
Authors: Parent Olivier , Zouache Abdallah 
Published: August 2022

Abstract

In this paper, we aim to identify the main factors that explain the occurrence and intensity of armed conflicts in a specific region, the Middle East and North Africa. We extend the linear Bayesian Model Averaging procedure to allow for the outcome, conflict intensity, to be measured on an ordered scale. Our research led us to expand the traditional dichotomous outcome, war versus peace, into a conflict intensity measure dissociating the state of peace from four different levels of violence. We provide strong evidence that not only demographical, institutional and socio-economic but also, environmental factors must be considered when analyzing conflict intensity. Those factors being innately intertwined, we advise policy makers not to rely on a particular theory to assess policy decisions. By paying special attention to neighboring states’ characteristics, our results reveal that political economy factors, historical legacy, climate and access to natural resources are key in identifying conflict severity. Finally, we show that model averaging predictions for ordered categorical outcomes improve upon the existing out-of-sample conflict prediction techniques.JEL Codes: O11, O15, C11, C52
Characterizations of type 1 subdiagonal algebras and an application
Authors: Zhang Ruihan , Ji Guoxing 
Published: August 2022

Abstract
Let A be a maximal subdiagonal algebra in a σ-finite von Neumann algebra M with respect to a faithful normal conditional expectation Φ. We consider the characterizations for A to be a type 1 subdiagonal algebra in the sense that every right invariant subspace in noncommutative H2 space is of Beurling type. As an application, we give a necessary and sufficient condition that a nest subalgebra AlgN with an injective nest N is a type 1 subdiagonal algebra in a factor von Neumann algebra M.MSC Classification: 46L52 , 47L75 , 46K50 , 46J15
H2O2 /pH dual-responsive biomimetic nanoenzyme drugs delivery system for enhanced tumor photodynamic therapy
Authors: Li Xinyuan , Ji Qing , Yan Chao , Yan Zhihui , Wang Yisen , Song Li 
Published: August 2022

Abstract
Phototherapy has been recognized as a photochemical process to treat tumor via induce cancer cells necrosis and death, with minimal invasiveness, higher selectivity and few side effects. However, the therapy effects of phototherapy are often compromised by the hypoxia, high levels of hydrogen peroxide and glutathione of tumor microenvironment (TME). Therefore, we constructed a catalase-like activity bionic metal-organic framework drugs delivery system (FA-EM@MnO2/ZIF-8/ICG) with tumor microenvironment controllable releasing. In this system, photosensitizer Indocyanine Green (ICG) was introduced into zeolite imidazole salt skeleton 8 (ZIF-8) by one-step methods, forming ZIF-8/ICG nano-platform, which can effectively avoid ICG-induced phototoxicity and aggregation-induced quenching during transport. MnO2 with catalase-like activity was coated on the surface of ZIF-8/ICG nano-platform, which made it have the ability of self-supplying O2 under the condition of H2O2 in TME. Exposure under near-infrared light can alleviate the anoxic TME, thus improving the phototherapy efficiency. In addition, folate-functionalized erythrocyte membrane is coated on the surface of MnO2/ZIF-8/ICG, which can endow FA-EM@MnO2/ZIF-8/ICG with the ability of targeted drug administration and immune elimination avoidance. Therefore, FA-EM@MnO2/ZIF-8/ICG nano-platform has the catalase-like activity, which can alleviate the oxidative stress state of TME and provide a beneficial environment for photodynamic therapy of tumor.
Doppler-free dual-excited state spectroscopy and its application for measurement of hyperfine structure of 6D5/2 level of133 Cs
Authors: Yang Baodong , Gou Zhiyu , Wang Junmin , Zhou Haitao 
Published: August 2022

Abstract
Based on cesium 6S1/2 − 6P3/2 − 6D5/2 (852 nm + 917 nm) ladder-type system, we simultaneously obtain the Doppler-free saturated absorption spectroscopy (SAS) of the 6S1/2 − 6P3/2 transition and optical-optical double resonance (OODR) spectroscopy of the 6P3/2 − 6D5/2 transition when the frequency of 852 nm laser is scanned over the 6S1/2 − 6P3/2 transition while keeping the 917 nm laser resonant on the 6P3/2 − 6D5/2 transition. The SAS as a frequency scale is used to measure the frequency intervals of hyperfine splitting of the 6D5/2 excited state via the OODR spectra. With the measured values of hyperfine splitting, the hyperfine coupling constants of the 6D5/2 state are determined as magnetic dipole Ahfs = -4.60 (5) MHz and electric quadrupole Bhfs = 0.23 (47) MHz, which are consistent with previous results. A simple and self-calibration method of measuring the unknown hyperfine structure of an atomic excited state using its own known hyperfine splitting of another state is demonstrated without the aid of any extra frequency calibration tools.
Effects of scallop visceral mass and mantle as dietary supplements on the physiology, immune response and intestinal microflora of sea cucumber Apostichopus japonicus
Authors: Yu Yu , Wang Mengshu , Ren Yichao , Wang Xin , Ge Xiangyun , Li Kecheng 
Published: August 2022

Abstract
To find a way to reuse scallop visceral mass and mantle, these aquatic byproducts were used as dietary supplementation and their effects on sea cucumber Apostichopus japonicas culture were investigated, including the growth performance, fatty acid and amino acid compositions, non-specific immune responses and intestinal microflora. The results indicated that the specific growth rate (SGR) of A. japonicas was significantly improved within 20 days by dietary supplementation of scallop visceral mass. Scallop visceral mass supplementation also markedly increased the contents of ω-3 fatty acids including EPA and DHA and ω-3/ω-6 ratio of sea cucumber tissue, which is beneficial to the health of sea cucumber and its commercial value. Furthermore, it is found that supplementation of scallop visceral mass and mantle both enhanced the non-specific immunity and optimized the composition of intestinal microflora of A. japonicas by increasing microbial diversity and promoting the abundance of beneficial taxa. This study reveals the promising prospect of high-value utilization of these scallop “wastes” in sea cucumber culture industry.
Health risk of consuming Sphoeroides spp. from the Navachiste Lagoon Complex due to its trace metals and organochlorine pesticides content
Authors: Armenta Gabriela Muñoz , Pérez-González Ernestina , Rodríguez-Meza Guadalupe Durga , González-Ocampo Hector Abelardo 
Published: August 2022

Abstract
The Navachiste complex (NAV) is impacted by neighbored human activities and is located in the southwestern coastal zone of the Gulf of California. The study determines the trace metal (TM) and organochlorine pesticides (OCP) health risk content in the edible tissue of Sphoeroides spp. from NAV. The daily intakes (EDI), target hazard quotient (THQ), hazard index (HI), and carcinogenic and non-carcinogenic risks were calculated. Twenty OCP and seven TM were detected with the following trend for TM: Zn > Fe > Pb > Ni > Mn > Cu > Cd. Cd, Cu, Fe, Mn, Pb, and Zn were above MRLs. The γ‒Chlordane was the most frequent OCP. The highest average concentration was for α‒HCH, followed by γ‒chlordane. With the high ratios of γ‒HCH, p, p'‒ DDD and p, p'‒DDD, and the absence of p, p'‒ DDT, the higher ratios for dieldrin and endrin than for aldrin, α‒ chlordane, γ‒chlordane, heptachlor, and heptachlor epoxide indicates historical contamination. In contrast, the residual products of methoxychlor, endosulfan, and its isomers indicate endosulfan's recent use. The TM EDI, THQ > 1 (at 120 g day-1), and the ILCR (> 1 × 10-6) were above minimum levels, showing a high-risk potential for cancer development in the long term.
Assess the performance of microstructural and optoelectronic properties of dual porous silicon decorated by ZrO 2 /Al 2 O 3 nanoparticles
Authors: Ghrib Mondher , Alenizi Maha A. , Zaghdoudi Mariem , Dimassi Wisem , Ghrib Taher , Gaidi Mounir , Ouertani Rachid , Ezzaouia Hatem 
Published: August 2022

Abstract
Nanoparticles of Al2O3 and ZrO2 were deposited in dual Silicon nanopores by chemical vapor deposition (CVD).This work presents a study of the integration effect of the alumina nanoparticle on morphological and opto-electronic properties of a porous Sidp/ZrO2 composite. Various techniques have been used such as scanning electron microscope, energy dispersion X-ray spectroscopy,X-ray diffraction, spectroscopic ellipsommetry and impedance analyzer techniques for coroled between morpho-structural and opto-electronic properties. After correlating the opto microstructural and electrical properties, we find this process simple, easy and efficient to produce high quality Sidp/ZrO2/Al2O3 thin films for optoelectronic applications.
Mutual Diffusivities of Binary Mixtures of Water and Poly(ethylene) Glycol from Heterodyne Dynamic Light Scattering
Authors: Wu Wenchang , Supper Malvina , Rausch Michael Heinrich , Kaspereit Malte , Fröba Andreas Paul 
Published: August 2022

Abstract
In the present study, the mutual diffusivity D11 in binary mixtures of water with technical polydisperse poly(ethylene) glycol (PEG) blends with molar masses of (1000, 4000, or 6000) g⋅mol−1 as well as with a purified monodisperse PEG homolog with a polymerization number of 21 and a molar mass of 943 g⋅mol−1 was investigated by heterodyne dynamic light scattering (DLS) as a function of temperature and/or PEG concentration. The measured D11 for technical PEG 1000 and pure PEG 943 match within the experimental uncertainties and agree well with the available literature data. D11 decreases with increasing molar mass of the PEGs at constant temperature and weight fraction. For the technical PEG 4000, it could be shown that D11 increases with increasing temperature and exhibits a non-linear concentration dependence. This study demonstrates that heterodyne DLS can be applied for the reliable determination of D11 of aqueous solutions of PEGs over a broad range of PEG weight fractions from 0.01 up to the solubility limit with an average expanded uncertainty (k = 2) of 5.5%. Moreover, the results show that monodisperse PEGs are suitable model systems for studying the diffusion behavior of bimodal and also multimodal particulate systems.
Renal Trauma in Pediatric Patients Transferred to Tertiary Care Center
Authors: LaCouture Hunter , Sandridge Brionna , Halstead Valeska , Sevick Carter , Beltran Gemma , Vemulakonda Vijaya M. 
Published: August 2022

Abstract
PURPOSE:Patients with traumatic kidney injuries often require transfer to tertiary trauma centers. The purpose of our study is to describe the outcomes of pediatric patients who were transferred from an outside hospital versus those presenting initially to our level 1 pediatric trauma center.METHODS: We performed a retrospective chart review of patients 0-18 years-olds seen at our level 1 pediatric trauma center following acute renal trauma after external trauma of any AAST grade and any mechanism of injury. Data collected included clinical complications, number of follow-up visits, long-term sequelae, and imaging techniques used. Statistical analyses using Fisher’s Exact and Kruskal-Wallis tests were performed. RESULTS:26 transferred and 9 non-transferred patients met inclusion criteria. There were no statistically significant differences in repeat imaging, immediate complications, follow-up visits, or long-term adverse outcomes for transferred vs. non-transferred patients. When comparing patients who transferred <50 miles versus >=50 miles, there was a non-significant increase in immediate complications in the >=50 miles group. CONCLUSIONS: Transferred patients receive similar radiation exposure and may not be at increased risk for immediate or long-term complications. Future studies are needed to determine optimal criteria for transfer of renal trauma pediatric patients to level 1 trauma centers.