bluuebunny/crossref_metadata_2025_split huggingface dataset:
Munc13 and SNAP25 dependent tethering plays a key role in synaptic vesicle priming
Authors: Papantoniou Christos , Laugks Ulrike , Betzin Julia , Capitanio Cristina , Javier Ferrero José , Sánchez-Prieto José , Schoch Susanne , Brose Nils , Baumeister Wolfgang , Cooper Benjamin H. , Imig Cordelia , Lučić Vladan 
Published: April 2022

AbstractSynaptic vesicle tethering, priming, and neurotransmitter release require a coordinated action of multiple protein complexes. While physiological experiments, interaction data, and structural studies of purified systems were essential for our understanding of the function of the individual complexes involved, they cannot combine high structural detail with the unperturbed organization of complexes within cells to resolve how the actions of individual complexes integrate. We employed cryo-electron tomography to simultaneously image multiple presynaptic protein complexes and lipids at molecular resolution in their native composition, conformation and environment. Our results argue that tethers comprising proteins Munc13 and SNAP25 differentially and spatially confine vesicles with single nanometer precision, define vesicle tethering states, and provide molecular mechanisms that guide vesicles towards fusion, which includes molecular priming by conversion to SNARE complex-dependent tethers. These findings present an example of a cellular function performed by an extended molecular assembly comprising multiple, molecularly diverse complexes.
Predicting the creep behavior of concrete at high temperature using the variable-order fractional model
Authors: Meng Ruifan 
Published: April 2022

PurposeCreep behavior of concrete at high temperature has become a major concern in building structures, such as factories, bridges, tunnels, airports and nuclear buildings. Therefore, a simple and accurate prediction model for the high-temperature creep behavior of concrete is crucial in engineering applications.Design/methodology/approachIn this paper, the variable-order fractional operator is introduced to capture the high-temperature creep behavior of concrete. By assuming that the variable-order function is a linear function with time, the proposed model benefits from the advantages of both formal simplicity and the physical significance for macroscopic intermediate materials. The effectiveness of the model is demonstrated by data fitting with existing experimental results of high-temperature creep of two representative concretes.FindingsThe results show that the proposed model fits well with the experimental data, and the value of order is increasing with the increase of the applied stress levels, which meets the fact that higher stress can accelerate the rate of creep. Furthermore, the relationship between the model parameters and loading conditions is deeply analyzed. It is found that the material coefficients are constant at a constant temperature, while the order function parameters are determined by the applied stress levels. Finally, the variable-order fractional model can be further written into a general equation of time and applied stress.Originality/valueThis paper provides a simple and practical variable-order fractional model for predicting the creep behavior of concrete at high temperature.
Sentiment lexicon construction for Chinese book reviews based on ultrashort reviews
Authors: Zha Mengjuan , Hu Changping , Shi Yu 
Published: April 2022

PurposeSentiment lexicon is an essential resource for sentiment analysis of user reviews. By far, there is still a lack of domain sentiment lexicon with large scale and high accuracy for Chinese book reviews. This paper aims to construct a large-scale sentiment lexicon based on the ultrashort reviews of Chinese books.Design/methodology/approachFirst, large-scale ultrashort reviews of Chinese books, whose length is no more than six Chinese characters, are collected and preprocessed as candidate sentiment words. Second, non-sentiment words are filtered out through certain rules, such as part of speech rules, context rules, feature word rules and user behaviour rules. Third, the relative frequency is used to select and judge the polarity of sentiment words. Finally, the performance of the sentiment lexicon is evaluated through experiments.FindingsThis paper proposes a method of sentiment lexicon construction based on ultrashort reviews and successfully builds one for Chinese books with nearly 40,000 words based on the Douban book.Originality/valueCompared with the idea of constructing a sentiment lexicon based on a small number of reviews, the proposed method can give full play to the advantages of data scale to build a corpus. Moreover, different from the computer segmentation method, this method helps to avoid the problems caused by immature segmentation technology and an imperfect N-gram language model.
Inorganic additive-incorporated composites with infrared radiation performance for thermal management
Authors: Wu Yingsi , Thum Kai Yang , Yong Hui Ting , Gora Aleksander , Tok Alfred Iing Yoong , Lipik Vitali 
Published: April 2022

PurposePersonal thermal management in functional textiles is in increasing demand for health care, outdoor activity and energy saving. Thus, developing new strategies is highly desired for radiative cooling and/or heating by manipulation of the transmissivity, reflectivity and absorptivity of the textiles within solar energy and human body heat radiation ranges.Design/methodology/approachInorganic additives including TiO2, Fe2O3, carbon black (CB), graphene and mica were incorporated into polymer films. The inorganic additives' full spectrum properties and thermal responses were comprehensively investigated.FindingsThe CB composite film showed the highest absorptivity over the full solar to human body radiation spectrum. The mica-white (mica-w) (mica coated with TiO2) and mica-red (mica-r) (mica coated with Fe2O3) composites showed the lowest solar energy absorptivity and a strong body heat radiation reflectivity. Furthermore, according to composites' thermal responses to the simulated solar and human body radiations, CB and mica are promising for both cooling and heating when applied in dual-functional thermal management textiles.Research limitations/implicationsResearch has limitation related the amount of additives which can be added to textile. When powder is added to polyester yarn, the amount is limited by 2–3%. When powder is added to the composite which is used for printing, the amount of powder is limited by 5%.Practical implicationsA lot of apparel, especially sport apparel, contains prints. Decoration is one part of print application. Now, a lot of companies work under development of different additives, which provide additional properties to apparel. The closest targets for powder added to prints are cooling and heat retention. Quite often, inorganic additives possess dual properties: the inorganic additives may be heat reflective which his needed for heat retention, but may have high-thermal conductivity, which works well for cooling. Human body has complicated mechanism of heat exchange: convection, radiation and moisture evaporations play main role. The same additive may be cooling if there is a contact with skin but may be heating (IR reflective) if placed in the second or third layer. Thus, effect is needed to be studied first before real application.Originality/valueThis work could provide a comprehensive guideline for the rational design and application of thermal management composite textile materials by revealing the full solar to human body radiation performance of a series of inorganic materials.
Social problem scale, public investment and social entrepreneurship action
Authors: Kimmitt Jonathan , Mandakovic Vesna , Muñoz Pablo 
Published: April 2022

PurposeSocial entrepreneurs engage in action because social entrepreneurs want to solve social problems. Consequently, to see more social entrepreneurship in contexts with the most severe social problems is expected. This paper argues that this is an oversimplification of the problem-action nexus in social entrepreneurship and that action does not necessarily correspond to the observed scale of social problems. Drawing on the theoretical framing of crescive conditions, this relationship is affected by forms of public investment as institutions that distinctively promote engagement and public interest amongst social entrepreneurs. Thus, this paper assesses the relationship between varying levels of social problems and social entrepreneurship action (SEA) and how and to what extent public investment types – as more and less locally anchored crescive conditions – affect this relationship.Design/methodology/approachThe hypotheses are tested with a series of random-effects regression models. The data stem from the Global Entrepreneurship Monitor's (GEM) 2015 social entrepreneurship survey and Chile's 2015 National Socioeconomic Characterisation Survey (CASEN). The authors combined both data sets and cross-matched individual-level data (action and investment) with commune-level data (social problem scale) resulting in unique contextualised observations for 1,124 social entrepreneurs.FindingsContrary to current understanding, this study finds that SEA is positively associated with low-social problem scale. This means that high levels of deprivation do not immediately lead to action. The study also finds that locally anchored forms of investment positively moderate this relationship, stimulating action in the most deprived contexts. On the contrary, centralised public investment leads to increased social entrepreneurial action in wealthier communities where it is arguably less needed.Originality/valueThe findings contribute to the literature on SEA in deprived contexts, social and public investment as well as policy-level discussion and broader issues of entrepreneurship and social problems.
Perspectives of Syrian refugees on antibiotic use and prescribing in Dutch primary care: a qualitative study
Authors: Alkirawan Rima , Kawous Ramin , Bloemen Evert , van den Muijsenbergh Maria , Goosen Simone , Suurmond Jeanine , de Boer Fijgje 
Published: April 2022

Purpose
This study is oriented towards getting insight into the perspectives, knowledge and practices among Syrian refugees regarding antibiotic use and prescribing in Dutch primary care.

Design/methodology/approach
A thematic qualitative study was carried out using semi-structured interviews with 12 Syrian refugees living in the Netherlands. Data analysis consisted of three steps and was oriented towards the development of themes.

Findings
Participants were confronted with restricted access to antibiotics in the Netherlands which was contrary to their experiences in Syria. Some of them continued to self-prescribe antibiotics, while others adhered to the Dutch General Practitioner (GP)’s advice. Especially mothers with young children took up the Dutch GP’s advice. Syrian refugees expressed health beliefs about the healing effects of antibiotics which are related to their past experiences of use and which influenced their current use. Respondents complained about the Dutch health-care system and expressed a preference for the one in Syria.

Research limitations/implications
Syrian refugees vary in their way of dealing with restricted access to antibiotics in Dutch primary care. More in-depth knowledge is required to improve refugee patient–doctor communication about antibiotic use.

Practical implications
The message that antibiotics are not needed may be challenging. Additional communication seems to be necessary to persuade Syrian refugees from self-prescribing antibiotics. Therefore, identifying refugee patient concerns and carefully counseling and communicating it with them is substantial. Developing educational toolkits consisting of various experiences of antibiotic use and ways of dealing with it can equip doctors to more adequately react to migrants’ needs for care.

Social implications
Primary care professionals seem insufficiently equipped to tackle issues related to antibiotic use amongst newly arrived migrants. Therefore, it is important to support professionals in their communication with this patient group about the proper use of antibiotics.

Originality/value
This study shows that more in-depth knowledge is needed about the strategies of newly arrived migrants and their complex reactions to treatment prescriptions with which they are not familiar.
A trust-enhanced consensus reaching model based on interaction among decision-makers with incomplete preferences
Authors: Jian Xinglian , Cai Mei , Wang Ya , Gao Yu 
Published: April 2022

PurposeThe development of social networks enhances the interaction between people, which brings new challenges to the research of group decision-making (GDM). This study aims at the problem that the synergy and redundancy due to interaction among decision-makers are ignored in the previous GDM, a trust-enhanced consensus reaching model based on interaction among decision-makers with incomplete preferences is proposed.Design/methodology/approachFirstly, confidence level is introduced to improve the hesitation phenomenon that should be considered when calculating trust degree; Secondly, a new trust propagation operator is developed to deal with indirect trust relationships; Thirdly, trust degree is transformed into interaction index to quantify the synergy and redundancy in decision-making. Fuzzy capacities of decision-makers are used to replace traditional weights, and the final scores of alternatives are obtained through Choquet integral.FindingsThe proposed model using fuzzy capacity can reflect the synergy or redundancy among decision-makers and improve the accuracy of final ranking result and reduce the loss of information.Originality/valueThis study proposes a trust-enhanced consensus reaching model, which develops a new trust propagation operator to ensure the continuous attenuation of trust in propagation process. And the proposed model uses fuzzy capacity to improve the enhancement or attenuation on the scores of alternatives.
Stakeholder power play: Delta Airlines, voter rights and Georgia Senate Bill 202
Authors: Raible Stephanie , Adeyinka Olugbenga , Holtzen Sarah , Douglas Megan 
Published: April 2022

Theoretical basis
This case addresses stakeholder theory by asking students to consider the various entities that have a vested interest in Delta’s response to the passage of the Senate Bill (SB) 202. Stakeholder theory holds that businesses are responsible to broader constituents in society and not only to stockholders/shareholders or owners. This perspective suggests that businesses do not exist to maximize profit alone but also to enhance society in their day-to-day decisions. To this end, stakeholders are defined as entities that affect or are affected by an organization’s decisions. Stakeholder theory is based on three arguments: descriptive, instrumental and normative arguments.

Research methodology
The information presented in the case was sourced from secondary sources, including both company and media publications. Several media sources from a breadth of political orientations were used to capture the complexity of the issue and the decision at hand. The case development and premise started at the Eastern Academy of Management 2021 Annual Conference Case Hackathon. The case was piloted by eight students (seven undergraduates, one graduate student) in two different courses at two institutions. The student feedback helped to highlight where clarifications were needed within the case and resulted in modifications to the exhibits, appendices and discussion questions.

Case overview/synopsis
On March 26, 2021, the media was buzzing about the passage of the Georgia SB 202, which included voting regulations perceived to negatively target black voters. As the head of the state’s largest employer, Delta Airlines’ Chief Executive Officer Edward Bastian found himself at the center of a heated political issue. While Delta had initially shown support for the bill, the rise in opposing voices and pressure to boycott Delta presented increasing pressure to think about its various stakeholders and potentially reevaluate the company’s handling of the situation. Should Bastiasn stay consistent with Delta’s initial support of SB 202, speak out to oppose it or remain silent?

Complexity academic level
Undergraduate students within business ethics or business in society courses are the best audiences for the case. The case may also be used in courses that have a portion of their content on business ethics or business in society; these related courses with subsections, modules or themes in this area may include corporate strategy, social responsibility and political activism.
Gramicidin A is hydrolyzed by a d‐stereospecific peptidase produced by Bacillus anthracis
Authors: Kaman Wendy E. , Nazmi Kamran , Voskamp‐Visser A. Ingrid , Bikker Floris J. 
Published: April 2022

SummaryPreviously we described the discovery of a Bacillus spp. specific peptidase activity related to d‐stereospecific peptidases (DSPs). The peptidase showed a strong preference for d‐leucine and d‐valine amino acids. These amino acids are present in the structure of the non‐ribosomal peptide (NRP) antibiotics gramicidin A, B and C and polymyxin E. To examine if the Bacillus spp. DSP‐related peptidase can hydrolyze these NRPs, the effect of gramicidin A and C and polymyxin E on peptidase activity in Bacillus anthracis culture supernatant was monitored. It was found that both gramicidins inhibited the DSP‐related activity in a competitive manner. MALDI‐TOF analysis revealed that upon incubation with B. anthracis culture supernatant gramicidin A hydrolyzation products appeared. This study shows that the Bacillus spp. specific DSP‐like peptidase was potentially produced by the bacteria to gain intrinsic resistance against NRP antibiotics. These results are of utmost importance in research towards antimicrobial resistance, whereas transfer of DSP‐related activity to other clinically relevant pathogens can be a serious threat to human health.
Delivery anatomy kits help to keep practical veterinary classes during the COVID‐19 pandemic
Authors: Machado Luciana Cristina , Santos Sarah Ingrid P. , Mariano Clesio Gomes , Coutinho Meline de Paula , Guaraná Julia Belotto , Fantinato‐Neto Paulo , Ambrósio Carlos Eduardo 
Published: April 2022

AbstractTo address the restrictions caused by the COVID‐19 pandemic and to search for assistive learning tools for the subject of Animal Anatomy II and Applied Anatomy, 123 anatomical kits were prepared at the Animal Anatomy Laboratory for students of the Veterinary Medicine course at the University of São Paulo, Faculty of Animal Science and Food Engineering (FZEA/USP) in Pirassununga city, São Paulo, Brazil. The kits contained anatomical pieces for teaching splanchnology and topographic anatomy (two different classes), and they were elaborated based on effective preservation techniques for the preparation of animal anatomical pieces. At the end of each course, we sent an online questionnaire to the students for evaluation of the methodology used. Alternative methods were used to minimize the odour and non‐generation of chemical or microbiological contaminants. The acceptance of the kits was unanimous with adherence by all the students, who had the opportunity to experience the Anatomy class in its entirety, without leaving their homes.
Boundaries of Solidarity: Immigrants, Economic Contributions, and Welfare Attitudes
Authors: Magni Gabriele 
Published: April 2022

AbstractIn the politics of welfare, citizens often prioritize natives over immigrants. What conditions reduce welfare discrimination against immigrants? Original survey experiments from the United States, the United Kingdom, France, and Italy reveal that the divide between natives and immigrants remains the fundamental cleavage in the politics of welfare. All immigrants face welfare penalties, including immigrants from Western countries. Even young, progressive, highly educated, and economically secure native citizens strongly penalize immigrants. Although immigrants never fully overcome identity barriers, the welfare support gap between natives and immigrants decreases when immigrants have a long work history. A history of employment provides evidence of reciprocity through past contributions and signals immigrants’ commitment to the community. Other immigrants’ characteristics, such as higher education and proactive work attitude, fail to decrease the gap. This article contributes to the study of solidarity in diverse societies and the impact of immigration on the welfare state.
Contributions of Andrée Tixier‐Vidal (1923–2021) to modern cell biology
Authors: Tougard Claude , Galli Thierry , Goud Bruno 
Published: April 2022

AbstractThis article illustrates the main stages of the scientific career of Dr Andrée Tixier–Vidal, a pioneer in cell biology research in France. She made important discoveries in the field of hormone secretion and neuronal morphogenesis. She played a key role in developing pituitary and neuronal cultures and using electron microscopy to study cellular structures. Her scientific influence continues to irradiate through her students and collaborators.
Cooperative breeding in Neolamprologus bifasciatus, a cichlid fish inhabiting the deep reefs of Lake Tanganyika
Authors: Satoh Shun , Saeki Taiga , Kohda Masanori , Awata Satoshi 
Published: April 2022

AbstractCooperative breeding, a social system in which offspring receive care from other group members as well as their parents, occurs in insects, fish, birds and mammals. In this study, we report a new example of cooperative breeding in the cichlid fish (Neolamprologus bifasciatus). This species, endemic to Lake Tanganyika, Africa, inhabits rocky areas at depths below 30 m. Observations of eight nests using underwater video cameras showed that one to six subordinates were present in the nests of breeding pairs. The subordinates shared shelters with juveniles and breeders and engaged in brood/territorial defence and nest maintenance (removing sand from the nest), albeit at a lower frequency than female breeders. The frequency of sand digging by subordinates and female breeders decreased as the number of subordinates in the group increased, suggesting that subordinates reduce the costs of nest maintenance for breeders. The male breeders seldom showed territorial defence and nest maintenance. Subordinates exhibited submissive behaviours towards dominant breeders and larger subordinates within their breeding group, indicating a dominance hierarchy among group members. Gonad examination revealed that the subordinates of both sexes were sexually immature, suggesting that they may not participate in reproduction. An aquarium experiment showed that juveniles become subordinates in their natal nest and participate in territory defence. We conclude that N. bifasciatus is a cooperative breeder, with social systems and subordinate roles similar to those observed in other cooperatively breeding cichlids.