bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Recurrence Based on Intravascular Ultrasound Findings after EluviaTM Placement in Symptomatic Peripheral Arterial Disease
Authors: Yamada Takehiro , Tokuda Takahiro , Yoshioka Naoki , Koyama Akio , Nishikawa Ryusuke , Shimamura Kiyotaka , Aoyama Takuma 
Published: September 2022

Abstract
Background
Polymer-coated drug-eluting stents (Eluvia™) have shown favorable clinical outcomes in real-world registries. Predictors of recurrence after Eluvia™ placement have been identified among clinical parameters. However, there are no reports on predictors of recurrence after Eluvia™ placement based on intravascular ultrasound (IVUS) findings.
Materials and Methods
We analyzed clinical data from the ASIGARU PAD registry, a retrospective, multi-center, observational study that enrolled patients who underwent endovascular therapy (EVT) for superficial femoral and proximal popliteal arteries lesions using Eluvia™ or drug-coated balloon. The primary outcome was the identification of predictors of recurrence, including IVUS parameters at 12 months. The rate of target lesion recurrence was also assessed.
Results
IVUS images were obtained in 54 of 65 cases. Seven recurrence cases (13.0%) were observed within 12 months. The random survival forest method presented eight predictive variables of recurrence: Clinical Frailty Scale (CFS), distal stent edge area, distal plaque burden, age, sex, distal external elastic membrane (EEM) area, minimum stent area (MSA), and distal lumen area. Furthermore, the partial dependence plot showed that frailty (CFS ≥ 6), smaller distal stent edge area, higher and lower distal plaque burden, older and younger age, female sex, smaller distal EEM area, smaller MSA, and smaller and larger distal lumen area predicted recurrence after Eluvia™ placement within 12 months.
Conclusion
CFS, distal stent edge area, distal plaque burden, age, sex, distal EEM area, MSA, and distal lumen area were significant predictors of recurrence after Eluvia™ placement.
Clinical outcomes associated with re-excision after unplanned excision or re-excision after local recurrence in patients with nonmetastatic synovial sarcoma
Authors: Zhang Hongqiang , Sun Wei , Huang Wending , Yan Wangjun , Wang Hongbo , Qu Guolun , Wang Kangwei , Shang Changquan , Qu Xinglong , Wang Chunmeng , Chen Yong 
Published: September 2022

Abstract
Background: The unplanned excision of synovial sarcomas in centers that do not specialize in sarcoma treatment necessitates extensive wide re-excision to maintain adequate margins. The present study was developed to examine the efficacy in SS patients with and without residual tumor tissue following unplanned surgical excision, and to compare differences in prognostic outcomes between individuals with residual tumor tissue and those that experienced local recurrence.
Method: Synovial sarcoma patients that underwent re-excision in our center between 2009 and 2019 were included in unplanned excision and local recurrence groups, with patients in the unplanned excision group being further stratified into those with and without residual tumor tissue. Analyzed endpoints included overall survival (OS), local recurrence-free survival (LRFS), and distant relapse-free survival (DRFS). Prognostic factors associated with these three different survival outcomes were analyzed through the use of Kaplan-Meier curves and Cox regression approaches.
Result: In total, this study incorporated 121 synovial sarcoma patients (68 female, 53 male; median age: 36 years), including 33 (27.3%) with no residual tumor tissue, 31 (25.6%) with residual tumor tissue, and 57 (47.1%) in the local recurrence group. Patients were assessed over a median 51-month follow-up period. The respective median intervals to definitive surgery in the unplanned excision and local recurrence groups were 35 days and 60 days. The respective 5-year OS, 5-year LRFS, and 5-year DRFS were 76.9%, 80.6%, and 59.6% for the non-residual group, 73.0%, 80.4%, and Not Available (NA) for the residual tumor tissue group, and 75.2%, 77.3%, and NA in the local recurrence group.
Conclusion: In synovial sarcoma patients with positive margins or residual tumor tissue following unplanned surgical excision, re-excision procedures can yield improved local control and OS to levels similar to those observed in patients without residual tumor. Relative to patients with local recurrence, significantly improved local control and OS are observed for patients with residual tumor following immediate extensive R0 resection. These results thus suggest that following initial incomplete tumor excision, patients should be promptly transferred to centers specializing in the treatment of sarcomas for adequate re-excision.
Hymenolepis Diminuta Infection In An Adult’s Lung: A Rare Case Report
Authors: Liu Jingjie , Sun Wangyuan , Wu Chao , Tian Kang , Shi Bin 
Published: September 2022

Abstract
Hymenolepis diminuta is a cosmopolitan parasite of rats and mice which is very rare in humans but has been reported from various areas of the world. We report a human case of Hymenolepis diminuta pulmonary infection in Giangsu Province, China and it has never been reported in patient’s Lung before. In the process of the diagnosis, NGS technology helps a lot. The infection was treated with albendazole and showed clinical and parasitological cure.
Self-Escapism among Iranian Girl Adolescents: Validity and Reliability of Persian Translation Scale
Authors: Nooripour Roghieh , Ghanbari Nikzad , Mozaffari Nazir , Hosseinian Simin , Lavie Carl , Hosseini Seyed Ruhollah 
Published: September 2022

Abstract
This research was conducted to determine the validity and reliability of the Persian version of the self-escapism scale among Iranian girl adolescents aged 14–18. A cross-sectional study was conducted between January 2021 and August 2021 among Iranian girl adolescents. Five hundred sixty-six adolescents (340 girls and 226 boys) were selected using a convenience sampling method. The participants completed The Escapism Scale, Erikson Psychosocial Stage Inventory (EPSI), Satisfaction with Life Scale (SWLS), Hope Scale (AHS), Smartphone Addiction Scale-Short Version (SASSV), and General Self-efficacy (GSE). The Escapism Scale's validity and reliability were examined as construct validity based on the confirmatory factor analysis (CFA), reliability using Cronbach’s alpha, and divergent and convergent validity. Results of the CFA indicated that a two-factor model provides a good fit for the data: sbX2 = 179.99 (p < 0.01); SRMR = 0.07; RMR = 0.56, CFI = 0.91; NFI = 0.89; IFI = 0.91; NFI = 0.89; GFI = 0.93; AGFI = 0.90, RMSEA = 0.076). Cronbach’s alpha coefficient for the self-escapism was 0.73. There was a significant relationship between self-escapism with identity confusion (r = 0.164, P < 0.01) and identity coherence (P < 0.01, r = 29). The finding showed a significant negative relationship between self-escapism with AHS (r=-0.31), SWLS (r=-0.34), and GHS (r=-0.33). There was a significant positive relationship between self-escapism and SAS-SV (r = 0.19). Also, the findings have shown a relationship between self-escapism and gender. This scale has been recommended to assess self-escapism in Iranian adolescents and psychological evaluations.
The dual invasion of Amur honeysuckle and Emerald Ash Borer alters fungal driven decomposition in Midwestern forests
Authors: Reed Adam M , Richardson Carson , Rúa Megan A 
Published: September 2022

Abstract
Midwestern forests are currently impacted by two prominent invaders, the Emerald Ash Borer (EAB), Agrilus planipennis and Amur honeysuckle, Lonicera maackii. The loss of ash (Fraxinus spp.) trees due to EAB invasion can further facilitate honeysuckle invasion, driving changes in the composition of forest leaf litter. To evaluate the extent to which these changes alter ecosystem function, we conducted litter bag and culture-based decomposition experiments using leaf litter from sugar maple (Acer saccharum), oak (Quercus spp.), black ash (Fraxinus nigra), green ash (Fraxinus pennsylvanica), spicebush (Lindera benzoin), and Amur honeysuckle (Lonicera maackii). To further understand the mechanism driving differences in decay rates, we inoculated six species of decomposing fungi separately onto both single species and multispecies (half honeysuckle and half native species) leaf litter and measured decomposition rate, fungal growth and enzymatic activity in laboratory-based cultures. Honeysuckle leaf litter decomposed faster, had increased fungal growth, and had higher activity for carbon degrading enzymes compared to native species leaf litter. Furthermore, multispecies mixtures followed the same patterns as honeysuckle, suggesting that the addition of honeysuckle to leaf litter will accelerate ecosystem functions related to carbon breakdown. Consequently, forests that experience the invasion of honeysuckle and EAB induced loss of ash are likely to have faster rates of decomposition, potentially resulting in an influx of available nutrients.
Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis
Authors: Alli Abdel , Desai Dhruv , Elshika Ahmed , Conrad Marcus , Proneth Bettina , Clapp William , Atkinson Carl , Segal Mark , Searcy Louis , Denslow Nancy , Bolisetty Subhashini , Mehrad Borna , Morel Laurence , Scindia Yogesh 
Published: September 2022

Abstract
While the deposition of immune complexes in the glomeruli is thought to initiate lupus nephritis, the extent of tubular damage better predicts progression to end stage kidney disease than the glomerular injury. However, the mechanisms underlying tubular injury in lupus nephritis are incompletely understood. Iron accumulates in tubular epithelial cells of lupus nephritis patients and mice. Ferroptosis is a druggable, iron-dependent form of cell death that is characterized by lipid peroxidation but has received little attention in lupus nephritis. Here we identify intra-renal ferroptosis as a novel pathological feature in human and murine lupus nephritis of different etiologies. Kidneys of lupus nephritis patients and mice showed increased lipid peroxidation mainly in the tubular segments. Nephritic kidneys presented with an increase in Acyl-CoA synthetase long-chain family member 4, a pro-ferroptosis enzyme, an impaired glutathione synthesis pathway, and attenuated expression of glutathione peroxidase 4, a glutathione-dependent ferroptosis inhibitor. Semi targeted lipidomics of murine nephritic kidneys revealed increased esterification of the sn-2 chain of phosphatidylethanolamine with adrenic acid (P-18:0/22:4), the preferred lipid substrate for lipid peroxidation and ferroptosis. Using congenic mice and nephrotoxic serum-induced immune complex glomerulonephritis model, we show that conditional deletion of heavy chain ferritin (FtH1) in the proximal tubules exacerbates ferroptosis and tubular injury. These findings were recapitulated by knocking down FtH1 in human proximal tubular cells and underscore the critical role of iron and heavy chain ferritin in tubular injury during the evolution of glomerulonephritis. Of translational relevance, Liproxstatin-2, a novel second-generation ferroptosis inhibitor, prophylactically and therapeutically mitigated lupus nephritis patient serum-induced ferroptosis in human proximal tubular cells. Collectively, our findings identify intra-renal ferroptosis as a pathological feature and contributor to tubular injury in lupus nephritis.
Stability of Fixed Points in Generalized Fractional Maps of the Orders
0 &lt; α &lt; 1
Authors: Edelman Mark 
Published: September 2022

Abstract
Caputo fractional (with power-law kernels) and fractional (delta) difference maps belong to a more widely defined class of generalized fractional maps, which are discrete convolutions with some power-law-like functions. The conditions of the asymptotic stability of the fixed points for maps of the orders 0 < α < 1 that are derived in this paper are narrower than the conditions of stability for the discrete convolution equations in general and wider than the well-known conditions of stability for the fractional difference maps. The derived stability conditions for the fractional standard and logistic maps coincide with the results previously observed in numerical simulations. In nonlinear maps, one of the derived limits of the fixed-point stability coincides with the fixed-point - asymptotically period two bifurcation point.
PACS 05.45.Pq · 45.10.Hj
Mathematics Subject Classification (2000) 47H99 60G99 · 34A99 · 39A70
Bedaquiline resistance probability to guide treatment decision making for rifampicin-resistant tuberculosis - insights from a qualitative study
Authors: Tu Pham Hien Trang , Anlay Degefaye Zelalem , Dippenaar Anzaan , Conceição Emilyn Costa , Loos Jasna , Rie Annelies Van 
Published: September 2022

Abstract
Background
Bedaquiline (BDQ) is a core drug for rifampicin-resistant tuberculosis (RR-TB) treatment. Accurate prediction of a BDQ-resistant phenotype from genomic data is not yet possible. A Bayesian method to predict BDQ resistance probability from next-generation sequencing data has been proposed as an alternative.
Methods
We performed a qualitative study to investigate the decision-making of physicians when facing different levels of BDQ resistance probability. Fourteen semi-structured interviews were conducted with physicians experienced in treating RR-TB, sampled purposefully from eight countries with varying income levels and burden of RR-TB. Five simulated patient scenarios were used as a trigger for discussion. Factors influencing the decision of physicians to prescribe BDQ at macro-, meso- and micro levels were explored using thematic analysis.
Results
The availability of BDQ and companion RR-TB drugs, the cost of BDQ, and the need for consultation with the clinical advisory committee shaped physicians' view on BDQ use and how they weighed BDQ resistance probability in their decision-making. Physicians’ view on the role of BDQ and accuracy of drug susceptibility testing impacted their perception of the BDQ resistance probability estimate. Physicians’ interpretation of BDQ resistance probability values varied widely. Probabilities between 25% and 70% were often seen as a grey zone, where physicians interpret the BDQ resistance probability dynamically, considering patient characteristics, including treatment response, history of exposure to BDQ, and resistance profile. In the grey zone, some physicians opted to continue BDQ but added other drugs to strengthen the regimen.
Conclusions
This study highlights the complexity of physicians' decision-making regarding the use of BDQ in RR-TB regimens for different levels of BDQ resistance probability. Structural barriers, physicians’ views on accuracy of drug susceptibility testing and patient characteristics influenced BDQ prescription and interpretation of the BDQ resistance probability. The development of a clinical decision support system incorporating BDQ resistance probability could facilitate the use of next generation sequencing and implementation of BDQ resistance probability in personalizing treatment for patients with RR-TB.
Priority areas to protect mangroves and maximise ecosystem services
Authors: Dabalà Alvise , DAHDOUH-GUEBAS Farid , Dunn Daniel , Everett Jason , Lovelock Catherine , Hanson Jeffrey , Buenafe Kristine Camille , Neubert Sandra , Richardson Anthony 
Published: September 2022

Abstract
Anthropogenic activities threaten global biodiversity and ecosystem services. Yet, area-based conservation efforts typically target biodiversity protection whilst minimising conflict with economic activities, failing to consider ecosystem services. Here we identify priority areas that maximise both the protection of mangrove biodiversity and their ecosystem services. We reveal that despite 13.1% of the mangrove distribution being currently protected, all mangrove species are not adequately represented and many areas that provide disproportionally large ecosystem services are missed. Optimising the placement of future conservation efforts to protect 30% of global mangroves potentially safeguards an additional 16.2 billion USD of coastal property value, 6.2 million people, 1,187.9 Mt C, and 51.7 million fisher days yr− 1. Our findings suggest that there is a pressing need for including ecosystem services in protected area design and that strategic prioritisation and coordination of mangrove conservation could provide substantial benefits to human wellbeing.
Can you spot a face? Face pareidolia is enhanced by 40 Hz transcranial Alternating Current Stimulation (tACS) of the face perception network
Authors: Palmisano Annalisa , Chiarantoni Giulio , Bossi Francesco , Conti Alessio , D’Elia Vitiana , Tagliente Serena , Nitsche Michael A. , Rivolta Davide 
Published: September 2022

Abstract
Pareidolia refers to the perception of ambiguous sensory patterns as carrying a specific meaning. In its most common form, pareidolia involves human-like facial features, where random objects or patterns are illusionary recognized as faces. The current study investigated the neurophysiological correlates of face pareidolia via transcranial Alternating Current Stimulation (tACS). tACS was delivered at gamma (40 Hz) frequency over critical nodes of the “face perception” network (the right lateral occipito-temporal and left prefrontal cortex) of 75 healthy participants while completing four face perception tasks (‘Mooney test’ for faces, ‘Toast test’, ‘Noise pareidolia test’, ‘Pareidolia task’) and an object perception task (‘Mooney test’ for objects). In this single-blind, sham-controlled between-subjects study, participants received 35 minutes of either Sham, Online, (40Hz-tACS_ON), or Offline (40Hz-tACS_PRE) stimulation. Results showed that face pareidolia was causally enhanced by 40Hz-tACS_PRE in the Mooney test for faces where, as compared to sham, participants more often misperceived scrambled stimuli as faces. In addition, 40Hz-tACS_PRE also caused faster responses to pareidolic faces in the visual noise stimuli of the Toast test. Similarly, in the Noise pareidolia test, 40Hz-tACS_ON induced slower rejections of face pareidolia responses. The current study shows for the first time that gamma-band (40 Hz) activity over the face perception network represents an important physiological substrate of face pareidolia. This has important implications for theories of human face perception and sheds light on basic pathophysiological mechanisms of clinical conditions where visual illusions and hallucinations represent core features.
Synthesis of core/shell nanocrystals with ordered intermetallic single-atom alloy layers for nitrate electroreduction to ammonia
Authors: Gao Qiang , Yao Bingqing , Pillai Hemanth , Zang Wenjie , Han Xue , Liu Yuanqi , Yu Shen-Wei , Yan Zihao , Min Bokki , Zhang Sen , Zhou Hua , Ma Lu , Xin Hongliang , He Qian , Zhu Huiyuan 
Published: September 2022

Abstract
Structurally ordered intermetallic nanocrystals (NCs) and single-atom catalysts (SACs) are two emerging catalytic motifs for sustainable chemical production and energy conversion. Yet, both have limitations in enhancing performance and expanding the materials design space. For example, intermetallic NCs require high-temperature annealing (> 500 °C) to promote atom rearrangement and d-d orbital hybridization, leading to potential aggregation or sintering, while SACs are typically limited by a low metal-atom loading (< 1 wt%) to avoid aggregation of metal atoms. Here, we report a facile, direct solution-phase synthesis of Cu/CuAu core/shell NCs with tunable single-atom alloy (SAA) layers. This synthesis can be extended to other Cu/CuM (M = Pt, Pd) systems, in which M atoms are isolated in the Cu host and can be considered the highest density of single-atom sites. We controlled the density of single-sites and the number of atomic layers and investigated the ligand and strain effects of Cu/CuAu for electrocatalytic nitrate reduction reaction (NO3RR). The Cu/CuAu densely packed SAAs demonstrated a high selectivity toward NH3 from NO3RR with an 85.5% Faradaic efficiency (FE) while maintaining an exceedingly high yield rate of 8.47 mol h-1 g-1. This work advances the design of atomically precise catalytic sites by creating a new paradigm of core/shell NCs with SAA atomic layers, opening an avenue for broad catalytic applications in achieving a sustainable energy future.
Genome-wide identification and expression analysis of the U-box E3 ubiquitin ligase gene family related to salt tolerance in sorghum (Sorghum bicolor L.)
Authors: Ren Genzeng , Cui Jianghui , Bai Yuzhe , Zhao Dongting , Han Yongliang , Chang Jinhua 
Published: September 2022

AbstractBackground:Plant U-box (PUB) E3 ubiquitin ligases play essential roles in many biological processes and stress responses, but little is known about their functions in sorghum (Sorghum bicolorL.).Results:In the present study, 59SbPUBgenes were identified in the sorghum genome. Based on the phylogenetic analysis, the 59SbPUBgenes were clustered into five groups, which were also supported by the conserved motifs and structures of these genes.SbPUBgenes were found to be unevenly distributed on the 10 chromosomes of sorghum. MostPUBgenes (16) were found on chromosome 4, but there were noPUBgenes on chromosome 5. Analysis ofcis-acting elements showed thatSbPUBgenes were involved in many important biological processes, particularly in response to salt stress. From proteomic and transcriptomic data, we found that severalSbPUBgenes had diverse expression under different salt treatments. To verify the expression ofSbPUBs, qRT-PCR analyses also were conducted under salt stress, and the result were consistent with the expression analysis. Furthermore, 12SbPUBgenes were found to contain MYB-related elements, which are important regulators of flavonoid biosynthesis. These results, which were consistent with our previous multi-omics analysis of sorghum salt stress, laid a solid foundation for further mechanistic study of salt tolerance in sorghum. Our study showed thatPUBgenes play a crucial role in regulating salt stress, and might serve as promising targets for breeding of salt-tolerant sorghum in the future.