bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insecticide resistance in malaria and arbovirus vectors in Papua New Guinea, 2017–2022
Authors: Katusele Michelle , Lagur Solomon , Endersby-Harshman Nancy , Demok Samuel , Goi Joelyn , Vincent Naomi , Sakur Muker , Dau Absalom , Kilepak Lemen , Gideon Stephen , Pombreaw Christine , Makita Leo , Hoffmann Ary , Robinson Leanne J. , Laman Moses , Karl Stephan 
Published: November 2022

Abstract
Background
Insecticide resistance (IR) monitoring is essential for evidence-based control of mosquito-borne diseases. While widespread pyrethroid resistance in Anopheles and Aedes species has been described in many countries, data for Papua New Guinea (PNG) are limited. Available data indicate that the local Anopheles populations in PNG remain pyrethroid-susceptible, making regular IR monitoring even more important. In addition, Aedes aegypti pyrethroid resistance has been described in PNG. Here, Anopheles and Aedes IR monitoring data generated from across PNG between 2017 and 2022 are presented.

Methods
Mosquito larvae were collected in larval habitat surveys and through ovitraps. Mosquitoes were reared to adults and tested using standard WHO susceptibility bioassays. DNA from a subset of Aedes mosquitoes was sequenced to analyse the voltage-sensitive sodium channel (Vssc) region for any resistance-related mutations.

Results
Approximately 20,000 adult female mosquitoes from nine PNG provinces were tested. Anopheles punctulatus sensu lato mosquitoes were susceptible to pyrethroids but there were signs of reduced mortality in some areas. Some Anopheles populations were also resistant to DDT. Tests also showed that Aedes. aegypti in PNG are resistant to pyrethroids and DDT and that there was also likelihood of bendiocarb resistance. A range of Vssc resistance mutations were identified. Aedesalbopictus were DDT resistant and were likely developing pyrethroid resistance, given a low frequency of Vssc mutations was observed.

Conclusions
Aedes aegypti is highly pyrethroid resistant and also shows signs of resistance against carbamates in PNG. Anopheles punctulatus s.l. and Ae. albopictus populations exhibit low levels of resistance against pyrethroids and DDT in some areas. Pyrethroid-only bed nets are currently the only programmatic vector control tool used in PNG. It is important to continue to monitor IR in PNG and develop proactive insecticide resistance management strategies in primary disease vectors to retain pyrethroid susceptibility especially in the malaria vectors for as long as possible.

Graphic abstract
Roles of physical exercise-induced MiR-126 in cardiovascular health of type 2 diabetes
Authors: Ma Yixiao , Liu Hua , Wang Yong , Xuan Junjie , Gao Xing , Ding Huixian , Ma Chunlian , Chen Yanfang , Yang Yi 
Published: November 2022

AbstractAlthough physical activity is widely recommended for preventing and treating cardiovascular complications of type 2 diabetes mellitus (T2DM), the underlying mechanisms remain unknown. MicroRNA-126 (miR-126) is an angiogenetic regulator abundant in endothelial cells (ECs) and endothelial progenitor cells (EPCs). It is primarily involved in angiogenesis, inflammation and apoptosis for cardiovascular protection. According to recent studies, the levels of miR-126 in the myocardium and circulation are affected by exercise protocol. High-intensity interval training (HIIT) or moderate-and high-intensity aerobic exercise, whether acute or chronic, can increase circulating miR-126 in healthy adults. Chronic aerobic exercise can effectively rescue the reduction of myocardial and circulating miR-126 and vascular endothelial growth factor (VEGF) in diabetic mice against diabetic vascular injury. Resistance exercise can raise circulating VEGF levels, but it may have a little influence on circulating miR-126. The Several targets of miR-126 have been suggested for cardiovascular fitness, such as sprouty-related EVH1 domain-containing protein 1 (SPRED1), phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2), vascular cell adhesion molecule 1 (VCAM1), high-mobility group box 1 (HMGB1), and tumor necrosis factor receptor-associated factor 7 (TRAF7). Here, we present a comprehensive review of the roles of miR-126 and its downstream proteins as exercise mechanisms, and propose that miR-126 can be applied as an exercise indicator for cardiovascular prescriptions and as a preventive or therapeutic target for cardiovascular complications in T2DM.
Towards real-time probabilistic ash deposition forecasting for New Zealand
Authors: Trancoso Rosa , Behr Yannik , Hurst Tony , Deligne Natalia I 
Published: November 2022

AbstractVolcanic ashfall forecasts are highly dependent on eruption source parameters (ESPs) and synoptic weather conditions at the time and location of the eruption. In New Zealand, MetService and GNS Science have been jointly developing an ashfall forecast system that incorporates four-dimensional high-resolution numerical weather prediction (NWP) and ESPs into the HYSPLIT model, a state-of-the art hybrid Eulerian and Lagrangian dispersion model widely used for volcanic ash. However, these forecasts are based on discrete ESPs combined with a deterministic weather forecast and thus provide no information on output uncertainty. This shortcoming hinders stakeholder decision making, particularly near the geographical margin of forecasted ashfall and in areas with large gradients in forecasted ash deposition. Our study presents a new approach that incorporates uncertainty from both eruptive and meteorological inputs to deliver uncertainty in the model output. To this end, we developed probability density functions (PDFs) for three key ESPs (plume height, mass eruption rate, eruption duration) tailored to New Zealand’s volcanoes and combine them with NWP ensemble datasets to generate probabilistic ashfall forecasts using the HYSPLIT model. We show that the Latin Hypercube Sampling (LHS) technique can be used to representatively span this four-dimensional parameter space and allow us to add uncertainty quantification to rapid response forecast systems. For a case study of a hypothetical eruption at Tongariro, New Zealand we suggest that large parts of New Zealand’s North Island would not receive adequate warning for potential ashfall if uncertainties were not included in the forecasts. We also propose new probabilistic summary products to support public information and emergency responders decision making.
Early prediction model for prognosis of patients with hepatitis-B-virus-related acute-on-chronic liver failure received glucocorticoid therapy
Authors: Gao Shuai , Han Li-Yan , Fan Yu-Chen , Wang Kai 
Published: November 2022

Abstract
Background
Early prediction for short-term prognosis is essential for the management of hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF). In this study, we aim to establish a noninvasive model for predicting the 90-day mortality in patients with HBV–ACLF received glucocorticoid therapy.

Methods
Two hundred and eighty patients with HBV–ACLF were enrolled from July 2010 to June 2022. All patients received routine medicine treatment and 204 of them received additional glucocorticoid treatment. Then, the patients who received glucocorticoid treatment were randomly divided into a training cohort and a validation cohort. An early prediction model for 90-day mortality of HBV–ACLF was established in the training cohort and then validated in the validation cohort.

Results
HBV–ACLF patients received glucocorticoid treatment showed significantly better survival that those not (P < 0.01). In the training cohort, a noninvasive model was generated with hepatic encephalopathy grade, INR, total bilirubin, age and SIRS status, which was named HITAS score. It showed significantly better predictive value for 90-day mortality of HBV–ACLF than MELD score and Child–Turcotte–Pugh score in both the training cohort and validation cohort. Using the Kaplan–Meier analysis with cutoff points of 2.5 and 3.47, the HITAS score can classify HBV–ACLF patients into different groups with low, intermediate and high risk of death after glucocorticoid therapy.

Conclusions
We proposed a HITAS score, which was an early prediction model for the prognosis of HBV–ACLF. It might be used to identify HBV–ACLF patients with favorable responses to glucocorticoid treatment.
A multilevel examination of the association between COVID-19 restrictions and residence-to-crime distance
Authors: Lentz Theodore S. , Headley Konkel Rebecca , Gallagher Hailey , Ratkowski Dominick 
Published: November 2022

AbstractRestrictions resulting from the COVID-19 pandemic interrupted people’s daily routine activities. Rooted in crime pattern and routine activity theories, this study tests whether the enactment of a Safer-at-Home mandate was associated with changes in the distance between individuals’ home addresses and the locations of where they committed crimes (i.e., residence-to-crime distance). Analyses are based on violent (N = 282), property (N = 1552), and disorder crimes (N = 1092) reported to one police department located in a United States’ Midwest suburb. Multilevel models show that residence-to-crime distances were significantly shorter during the Safer-at-Home order, compared to the pre- and post-Safer-at-Home timeframes, while controlling for individual and neighborhood characteristics. Additionally, these relationships varied by crime type. Consistent with the literature, the findings support the argument that individuals tend to offend relatively near their home address. The current findings extend the state of the literature by highlighting how disruptions to daily routine activities stemming from the COVID-19 pandemic led to alterations in crime patterns, in which analyses indicated shorter distances between home address and offense locations.
Exploring the link between eating disorders and persistent genital arousal disorder/genito-pelvic dysesthesia: first description and a systematic review of the literature
Authors: Imgart Hartmut , Zanko Annika , Lorek Sandra , Schlichterle Patti-Sue , Zeiler Michael 
Published: November 2022

Abstract
Background
Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia (PGAD/GPD) characterized by recurrent physiological genital without corresponding psychological arousal is a poorly understood and researched condition. Based on the first two case descriptions of eating disorders directly linked to PGAD/GPD the aim of this paper was to systematically review the literature on possible associations between eating disorders and PGAD/GPD.

Method
A systematic literature search on eating disorders and PGAD/GPD was conducted in PubMed, PsycINFO, and Scopus, complemented by Google Scholar. We included case reports, case series, cross-sectional studies and review articles published in peer-reviewed journals written in English or German-language.

Results
The included original papers described a total of 2078 cases with PGAD/GPD symptomatology. Of these, 892 participants fulfilled all five PGAD/GPD core criteria. The aetiology of PGAD/GPD is unknown. Multifactorial genesis of PGAD/GPD is presumed including neurological, pharmacological, hormonal, vascular and psychological causes. A high degree of psychological comorbidity is reported. No study was found that drew a direct link between eating disorders and PGAD/GPD. Although PGAD/GPD symptoms also occur in adolescents, there are no findings in this regard. However, we found a gap in data collection: eating disorders as potential psychiatric comorbidities were systematically recorded in only a few studies.

Conclusion
The existing literature have not yet considered a possible link between eating disorders and PGAD/GPD so far. According to the authors’ knowledge, this work is the first review to systematically explore the associations. We suspect underreporting of PGAD/GPD cases in eating disorders and particularly during adolescence. We argue that there are several common factors that appear to be important in the etiology, course, and treatment of both disorders (e.g. hormonal dysregulation or sensory sensitivity and avoidance), warranting future research on the possible comorbidity of these disorders.
Mechanisms by which adverse childhood experiences, other traumas and PTSD influence the health and well-being of individuals with eating disorders throughout the life span
Authors: Brewerton Timothy D. 
Published: November 2022

Abstract
Background
Multiple published sources from around the world have confirmed an association between an array of adverse childhood experiences (ACEs) and other traumatic events with eating disorders (EDs) and related adverse outcomes, including higher morbidity and mortality.

Methods
In keeping with this Special Issue’s goals, this narrative review focuses on the ACEs pyramid and its purported mechanisms through which child maltreatment and other forms of violence toward human beings influence the health and well-being of individuals who develop EDs throughout the life span. Relevant literature on posttraumatic stress disorder (PTSD) is highlighted when applicable.

Results
At every level of the pyramid, it is shown that EDs interact with each of these proclaimed escalating mechanisms in a bidirectional manner that contributes to the predisposition, precipitation and perpetuation of EDs and related medical and psychiatric comorbidities, which then predispose to early death. The levels and their interactions that are discussed include the contribution of generational embodiment (genetics) and historical trauma (epigenetics), social conditions and local context, the ACEs and other traumas themselves, the resultant disrupted neurodevelopment, subsequent social, emotional and cognitive impairment, the adoption of health risk behaviors, and the development of disease, disability and social problems, all resulting in premature mortality by means of fatal complications and/or suicide.

Conclusions
The implications of these cascading, evolving, and intertwined perspectives have important implications for the assessment and treatment of EDs using trauma-informed care and trauma-focused integrated treatment approaches. This overview offers multiple opportunities at every level for the palliation and prevention of EDs and other associated trauma-related conditions, including PTSD.
Analytical studies on medieval lead ingots from Wrocław and Kraków (Poland): a step towards understanding bulk trade of lead from Kraków and Silesia Upland Pb–Zn deposits
Authors: Miazga Beata , Duma Paweł , Cembrzyński Paweł , Matyszczak Milena , Piekalski Jerzy 
Published: November 2022

Abstract
Origins of medieval lead artefacts are hard to establish due to re-smelting and mixing. One can obtain conclusive evidence from ingots that served for bulk trade and originated directly from the mines. This paper aims to analyse the thirteenth century lead ingot from Wrocław (Poland). To establish its origins we analysed its structure and chemical composition. We used archaeometric methods: light and electron microscopic observations, X-ray fluorescence spectrometry, X-ray diffraction, infrared spectroscopy, inductively coupled plasma-optical emission spectrometry and Pb isotopic analysis. We compared our measurements with measurements of analogical ingot found on Kraków Market Square and a database of lead ores from Europe and the Middle East. The research indicated that both ingots originated from -Kraków and Silesia Upland Pb–Zn ore deposits (Poland), intensively mined from the twelfth century. The results complement the view of trade routes established based on written records and add valuable data for future comparative studies.
A comparative evaluation of the effects of seed invigoration treatments with precursor zinc salt and nano-sized zinc oxide (ZnO) particles on vegetative growth, grain yield, and quality characteristics of Zea mays
Authors: Tondey Manisha , Kalia Anu , Singh Alla , Abd-Elsalam Kamel , Hassan Montaser M. , Dheri Gurmeet Singh 
Published: November 2022

Abstract
Introduction
The zinc micronutrient fertilizers have a critical impact on the grain productivity and quality attributes of maize. However, the low use-efficiency issues of the applied Zn-fertilizers are required to be addressed through the development of novel formulations and alternative application techniques.

Objectives
This field study investigates the comparative impact of seed invigoration (including seed priming and coating) treatments with bulk zinc and ZnO nanoparticles (ZnONPs).

Methods
The two seed treatments with two different zinc sources at three different concentrations of 0, 20, and 40 mg L−1 each, for a total of ten treatments, were evaluated for vegetative growth, photosynthetic pigments, grain yield, and quality traits in Zea mays.

Results
The total chlorophyll content was improved by ZnONPs seed priming at the V8 stage. However, there were plants that grew tall, bearing longer ears with bulk ZnSO4 and the untreated control. Yield-contributing factors like number of seeds per cob, and 1000-grain weight were marginally improved by ZnONPs treatment. Overall, only cob weight, starch, total soluble protein, and soil nutrient (N, P, K, and Zn) content were significantly enhanced by ZnONPs treatment. Furthermore, no negative effect was recorded on the soil microbiological and enzymatic activities seed treatment with both the zinc sources.

Conclusion
The seed treatment, i.e. coating and priming with ZnONPs, did not significantly alter the grain yield, but the seed starch and total soluble protein content were improved.
Thermal decarboxylation of acidic cannabinoids in Cannabis species: identification of transformed cannabinoids by UHPLC-Q/TOF–MS
Authors: Seo Chaeyoung , Jeong Minsun , Lee Sangin , Kim Eun Jae , Rho Soohyang , Cho Mansoo , Lee Yong Sup , Hong Jongki 
Published: November 2022

AbstractDecarboxylation of cannabidiolic acid (CBDA) is an important step for efficient production of the active pharmaceutical component cannabidiol (CBD) in Cannabis species. Acidic cannabinoids (ACBs) can be easily transformed into neutral cannabinoids via loss of carbon dioxide when exposed to heat. During the thermal process, several transformed products including psychotropic △9-tetrahydrocannabinol (△9-THC) and its isomers were produced through decarboxylation, hydration, isomerization, and oxidation, as identified by ultra-high-performance liquid chromatography quadrupole/time-of-flight mass spectrometry (UHPLC-Q/TOF MS). Their identification was carried out using authenticated standards and interpreting the MS/MS fragmentations. To investigate thermal decarboxylation, CBDA was extracted and isolated from inflorescence of Cannabis by ultrasonication extraction and two-step column chromatography. To investigate the decarboxylation yield of isolated CBDA and ACBs in Cannabis extract, samples were examined over a range of reaction temperatures (110–130 °C) and times (5–60 min). Time profiles of CBDA degradation and CBD formation were obtained as functions of the reaction temperature. In particular, most of the CBDA was converted into CBD at 130 °C for 20 min; this CBD was partially transformed to psychotropic THC isomers via cyclization. In addition to THC isomers, cannabielsoin acid (CBEA) and cannabielsoin (CBE) were also observed as minor oxidative transformed products. Based on structural identification and profiling data, thermal transformation pathways of CBDA are plausibly suggested. The results of decarboxylation of ACBs will provide important information on production of neutral cannabinoids, especially CBD, in Cannabis plants and quality control of Cannabis-based products in pharmaceutical and cosmetic industries.
Ovicidal and insecticidal effects of microbial pathogens against invasive Coconut Rugose spiralling whitefly (RSW), Aleurodicus rugioperculatus Martin and impact on their chrysopid predator Mallada boninensis (Okamoto)
Authors: Elango K. , Arun kumar N. , Dhanasekar V. 
Published: November 2022

AbstractBackgroundThe Rugose spiraling whitefly (RSW),Aleurodicus rugioperculatusMartin (Hemiptera: Aleyrodidae), has been reported as an invasive pest of coconut in different parts of peninsular India during 2016. It mainly caused damage to coconut palms, bananas, custard apples and other broad-leaved plants as hosts. Presently it is spread all over India and the coconut growing farmers are facing hard ships due to this infestation of RSW in coconut ecosystem. Still now the management of this invasive pest is fully based on the biological control, particularly with predators and parasitoids and the study on the microbial control of RSW was minimum. Hence, an attempt was made to study the ovicidal and insecticidal effects of microbial pathogens, viz.Isaria fumosoroseaWize,Beauveria bassiana(Balsamo) Vuillemi,Metarhizium anisopliae(Metschnikoff),Lecanicillium lecanii(Zimmerm.) with a spore load of 1 × 108 cfu against different life stages of RSW and their chrysopid predator,Mallada boninensis(Okamoto)(Neuroptera: Chrysopidae) under laboratory as well as field conditions.ResultsThe results revealed that under laboratory conditions,I. fumosoroseacaused 34.54% egg mortality, 37.39% nymphal mortality and 48.30% adult mortality, followed byL. lecanii(24.54, 30.76 and 28.01%) andM. anisopliae(20.56, 32.51 and 42.92%) for egg, nymphal and adult mortality, respectively. Under field conditions,I. fumosoroseacaused (29.60%), followed byM. anisopliae(24.30%) andB. bassiana(21.00%) nymphal mortality, respectively, at 15 days after spray, also, it was found effective in reducing the RSW population on coconut. The impact of fungal entomopathogens against the predator revealed thatI. fumosoroseatreated eggs ofM. boninensisrecorded maximum 90.33% grub emergence than other treatments.ConclusionThe present study concludes that the RSW can be controlled effectively byI. fumosoroseaalong with the chrysopid predator,M. boninensisunder field conditions as they showed maximum ovicidal and insecticidal actions against different life stages of RSW and safer to the major predator of RSW and fall under harmless category as per the classification of IOBC.