bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreaticoduodenal and choledochal hemangiomatosis with vascular variation in a child: a rare disease with challenge starts from diagnosis（a case report）
Authors: Tian Daguang , Zhu Hong , Wei xiaoping 
Published: February 2022

Abstract
Background Visceral hemangiomatosis is a benign tumor that is rarer than hemangioma and it has not been reported to occur at pancreas, duodenum and choledoch. So it is easy to be confused it with other pancreatic tumors or choledocholithiasis secondary to bile excretion disorder caused by compression of hemangiomatosis. Case presentation We reported a case of a 2 years and 9 months old child presented with repeated and fluctuating jaundice for 3 months following history of endoscopic stone removal with diagnosis of choledocholithiasis in local hospital. Abdominal CT revealed pancreatic head tumor which was undiagnosed before. A rare vascular variation as CMT was also found. Misdiagnosed as pancreatic neuroendocrine tumor, PD was performed. However, history reported pancreaticoduodenal and choledochal hemangiomatosis. Although the boy was in good condition and gained 4Kg in weight 3 months after operation, PD was not the best choice for him if we could make accurate diagnosis before or during operation. Conclusion Our report highlights the difficulty in diagnosing visceral hemangiomatosis and indicates the need for radiologists, endoscopists and surgeons to consider such a possibility when they are confronted with repeated and fluctuating jaundice which can’t be explained by simple choledocholithiasis.
Granulomatosis With Polyangiitis Involving the Fourth Ventricle: Report of a Rare Case and a Literature Review
Authors: Yuan Dan , Yang Xiao-rong , Li Ceng-fang , Ji Qing , Zhang Su-yuan , Wang Kai , Xia Jing-hua , Luo Suai Jin-jingWang , Wang Jin-jing 
Published: February 2022

Abstract
Background: Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune vasculitis disease that is highly correlated with antineutrophil cytoplasmic antibodies (ANCAs).It used to be called"Wegener's granulomatosis". The clinical manifestations are diverse, mainly involving the upper respiratory tract, lungs and kidneys, and this disease can involve the brain parenchyma as an isolated solid mass. Only one case has been reported thus far. To provide further information on this rare case, we report a case of granulomatous polyangiitis involving the fourth ventricle and review the relevant literature.Case characteristics: A 32-year-old Chinese female developed fever, cough, and shortness of breath for 20 days. An 8*8 cm skin ulcer was seen on the right lower limb. CT showed multiple large patches of increased density in both lungs. The patient’s serological anti-neutrophil cytoplasmic antibody cANCA was positive. Later, the patient developed dizziness and a headache. Magnetic resonance imaging of the head showed a mass of approximately 21x24 mm2 in the fourth ventricle. The patient had a craniotomy for mass resection, and macroscopically, the mass was gray–red and measured 2.5x2x2 cm and was soft, had local hemorrhage and necrosis, and had no capsule. The main microscopic features included necrotizing granulomatous vasculitis, the patient’s immunohistochemistry was positive for CD68 and negative for GFAP, and the acid-fast staining and hexaamine silver staining were negative. Combined with the clinical history, serology, and imaging, the pathological diagnosis was GPA in the fourth ventricle. The patient was switched to rituximab combined with steroid therapy because she did not tolerate cyclophosphamide. After 5 months of follow-up, the patient’s lung lesions and skin ulcers had completely improved, but the brain lesions had further progressed.Conclusion: When a patient has multiple system diseases, abnormal clinical manifestations, and positive serological ANCAs, a diagnosis of GPA should be carefully considered, and biopsies of easy-to-access sites should be performed. If the patient’s histopathological manifestations include necrotizing granulomatous vasculitis, a diagnosis of GPA is more likely. If a patient subsequently develops an intraventricular mass, the clinicians should consider a diagnosis of GPA, which can rarely involve the cerebral ventricle to avoid an unnecessary biopsy or surgical treatment of intracranial lesions. When a patient is intolerant to the traditional treatment drug cyclophosphamide and needs to be switched to rituximab, the treatment effect of intracerebral lesions is not ideal; therefore, the treatment of lesions involving GPA in the ventricle is worthy of further exploration.
Phb1 interacts with p53 in the regulation of mitochondrial dynamics and chemoresistance in gynecologic cancers
Authors: Kong Bao , Han Chae Young , Kim Se Ik , Patten David A , Han Youngjin , Carmona Euridice , Shieh Dar-Bin , Cheung Annie C. , Mes-Masson Anne-Marie , Harper Mary-Ellen , Song Yong Sang , Tsang Benjamin K. 
Published: February 2022

Abstract
Background: Mitochondrial dynamics (e.g. fission/fusion) play an important role in controlling chemoresistance in representative gynecologic malignancies, ovarian and cervical cancer. Processing the long form of Optic atrophy (L-Opa)1 is a distinctive character of mitochondrial fragmentation, associated with chemosensitivity. Here, we examined the role of prohibitin (Phb)1 in increasing L-Opa1 processing via the regulating mitochondrial protease, Oma1 and its direct interaction with p-p53 (ser15) and pro-apoptotic Bcl-2 antagonist/killer (Bak) 1 in the signaling axis and if this phenomenon is associated with prognosis of patients.Methods: We compared Cisplatin (CDDP)-induced response of mitochondrial dynamics, molecular interaction among p-p53 (ser15)-Phb1-Bak, and chemoresponsiveness in paired chemosensitive and chemoresistant gynecologic cancer cells (ovarian and cervical cancer cell lines) using western blot, immunoprecipitation, sea horse, and immunofluorescence. Translational strategy with proximity ligation assessment in phb1-p-p53 (ser15) in human ovarian tumor sections further confirmed in vitro finding, associated with clinical outcome.Results: We report that: (1) Knock-down of Phb1 prevents Cisplatin (cis‐diamine-dichloroplatinum; CDDP) -induced changes in mitochondrial fragmentation and Oma1 mediated cleavage, and Opa1 processing; (2) In response to CDDP, Phb1 facilitates the p-p53 (ser15)-Phb1-Bak interaction in mitochondria in chemosensitive gynecologic cancer cells but not in chemoresistant cells; (3) Akt overexpression results in suppressed p-p53(Ser15)-Phb1 interaction and dysregulated mitochondrial dynamics, and (4) Consistent with in vitro findings, proximity ligation assessment (PLA) in human ovarian tumor sections demonstrated that p-p53(ser15)-Phb1-Bak interaction in mitochondria is associated with better chemoresponsiveness and clinical outcome of patients. Determining the molecular mechanisms by which Phb1 facilitates mitochondrial fragmentation and interacts with p53 may advance the current understanding of chemoresistance and pathogenesis of gynecologic cancer.Conclusion: Determining the key molecular mechanisms by which Phb1 facilitates the formation of p-p53 (ser15)-Bak-Phb1 and its involvement in the regulation of mitochondrial dynamics and apoptosis may ultimately contribute to the current understanding of molecular and cellular basis of chemoresistance in this gynecologic cancer.
Severe Coagulopathy Caused By Cefminox Sodium: A Case Report
Authors: Wu Shuling , Bi Xiaoyue , Lin Yanjie , Yang Liu , Li Minghui , Yao Xie 
Published: February 2022

Abstract
A 55-year-old female patient with liver cirrhosis and hepatocellular carcinoma was treated with cefminox sodium for two times because of peritonitis. During the treatments, severe coagulopathy occurred, and the coagulation function quickly recovered after stopping the drug. The diagnosis and treatment of this patient provides us with ideas for dealing with similar problems in clinical practice in the future.
Solving Fundamental Life Testing Issues: An Application in Medical Science
Authors: Bakr M. E. , Gadallah A. M. , Al-Babtain Abdulhakim A. 
Published: February 2022

Abstract
In biomedical sciences, the application of probability models for survival experience has become increasingly significant. Survival models of classes of life distributions summarize the pattern of survival, recommend additional research, and offer theories and hypotheses. Nowadays, reliability is extremely crucial because complicated scientific gadgets, such as precise medical equipment, airplane equipment, and air defense equipment, are employed for exact scientific reasons. Furthermore, low or no reliability might result in an increase in the cost of device parts (spare parts), the loss of a person, or a threat to national security.
For decades, researchers have examined the use of the Laplace transform approach to test exponentiality. We proposed new tests for new better than utilized in expectation class in this post (NBUE). Critical values that have been censored and those that have not been censored are calculated. To evaluate the performance of this test, the powers for numerous regularly used alternatives are determined. The proposed test appears to have high efficacy and good powers for many regularly used alternatives. Finally, sets of medical real data are utilized to demonstrate how the proposed tests can be applied to solve real-world problems.
Fecal Metabolome and Bacterial Composition in Severe Obesity: Impact of Diet and Bariatric Surgery
Authors: Salazar Nuria , Ponce-Alonso Manuel , Garriga María , Sánchez-Carrillo Sergio , Hernández-Barranco Ana María , Redruello Begoña , Fernández María , Botella-Carretero José Ignacio , Vega-Piñero Belén , Galeano Javier , Zamora Javier , Ferrer Manuel , Gavilán Clara G. de los Reyes , Campo Rosa del 
Published: February 2022

Abstract
Background: The aim of this study was to monitor the impact of a preoperative diet and bariatric surgery on the bacterial gut microbiota composition and functionality in severe obesity and to compare sleeve gastrectomy (SG) versus Roux-en-Y gastric bypass (RYGB). The study also aimed to incorporate big data analysis for the omics results and machine learning by a Lasso-based analysis to detect the potential markers for excess weight loss.Methods: Forty patients who underwent bariatric surgery were recruited (14 underwent SG, and 26 underwent RYGB). Each participant contributed 4 fecal samples (baseline, post-diet, 1 month after surgery and 3 months after surgery). The bacterial composition was determined by 16S rDNA massive sequencing using MiSeq (Illumina). Metabolic signatures associated to fecal concentrations of short-chain fatty acids, amino acids, biogenic amines, gamma-aminobutyric acid and ammonium were determined by gas and liquid chromatography. Orange 3 software was employed to correlate the variables, and a Lasso analysis was employed to predict the weight loss at the baseline samples.Results: A correlation between Bacillota (formerly Firmicutes) abundance and excess weight was observed only for the highest body mass indexes. The crash diet had little impact on composition and targeted metabolic activity. RYGB had a deeper impact on bacterial composition and putrefactive metabolism than SG, although the excess weight loss was comparable in the two groups. Significantly higher ammonium concentrations were detected in the feces of the RYGB group. Conclusions: We detected individual signatures of composition and functionality, rather than a gut microbiota characteristic of severe obesity, with opposing tendencies for almost all measured variables in the two surgical approaches. The gut microbiota of the baseline samples was not useful for predicting excess weight loss after the bariatric process.
A Comparison between the Bayesian Network Model and the Logistic Regression Model in Prevention of the Defects on Ceramic Tiles
Authors: Sevinç Volkan , Kırca Meryem Merve 
Published: February 2022

Abstract
One of the most important problems occurring in ceramic tile industry is defective product problem. Defective ceramics leads to loss of income and waste of resources in enterprises. However, it is generally unknown which factors and production stages cause what kinds of defects. On the other hand, in the literature, the existing modeling studies usually consider the defects seen on industrial ceramics. The defect types of industrial ceramics and those of ceramic tiles are different. Moreover, the classification types encountered in both kinds of ceramics also differ from each other. This article investigates the reasons behind the defect occurrences on ceramic tiles, along with a comparison between a logistic regression model and a Bayesian network model. In the study, the model validation results of the logistic regression model and the Bayesian network model show that the Bayesian network model is more successful in estimating the defect types. Thus, the constructed Bayesian network model indicates that in general, the high speeds of the production band significantly increase the probabilities of all kinds of defects except the deformation defect. Additionally, the high densities of the glaze also increase the occurrence levels of the defects, except the deformation defect. Similarly, the high levels of the engobe weight and the engobe density are also among the factors increasing the defect occurrences.
Depressive symptoms and associated factors among public high school students in Bahir Dar City, Northwest Ethiopia: A cross-sectional study
Authors: Tarecha Debela , Mekonen Tesfa , Asnake Gizachew , Tarafa Hunde 
Published: February 2022

Abstract
Background: Depression is the most prevalent mental disorder in adolescents that lead to educational impairment, substance use problems, and suicidal attempts. The aim of this study was to assess depressive symptoms and their associated factors among public high school students in Bahir Dar city, Northwest Ethiopia.Methods: An institution-based cross-sectional study was conducted from March to April 2021 at Bahir Dar City public high school students. Data were collected from 781 participants using a self-administered questionnaire. Participants were selected using the multistage sampling method. Patient health questionnaire 9 modified for adolescents (PHQ-9A) was used to measure depressive symptoms. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 25. Logistic regression analysis was done to identify factors associated with depressive symptoms. Variables with P-value <0.05 were considered statistically significant.Result: The prevalence of depressive symptoms were found to be 19.7% (CI=16.9, 22.6). Depressive symptoms were significantly associated with female sex (AOR=2.36, 95% CI=1.54-3.61), having known medical conditions (AOR=1.85, 95% CI=1.03-3.31), poor social support (AOR=1.83, 95% CI=1.03-3.31), childhood abuse (AOR=2.02, 95% CI=1.28-3.20) and neglect (AOR=2.78, 95% CI=1.70-4.55), and occupation of mother (AOR=0.38 CI=0.15-0.95).Conclusions: One in five public high students reported depressive symptoms. Schools need to institute routine mental health screening services and implement appropriate interventions to initiate and improve access to school-based mental health services, particularly for female students.
Quality of Life of Kazakhstan’s Population: Assessment of the Main Parameters and Identification of Problem Areas
Authors: Chulanova Zaure K. 
Published: February 2022

Abstract
The purpose of the article is to study the main parameters characterizing the quality of life of the population of Kazakhstan in modern economic conditions and develop proposals for its improvement. The methodology of the study is based on a holistic approach, including the use of objective indicators of the quality of life that determine the material conditions and means of human livelihood, and subjective assessments of the population, social groups of their material and social well-being. Measuring and evaluating the level and quality of life of the population of Kazakhstan based on an integrated approach includes the use of the following methods: component analysis, normative and stratification, integral indicators, and subjective assessments of the population. The leading blocks of the life support system are considered, including the assessment of income and consumption in the conditions of maintaining socio-economic income differentiation; the social qualitative parameters of the life support system of the population, the most important indicators of the implementation of priority areas of development of labor potential in the innovative economy, modernization of housing policy are given.
Next-Generation Antivirus endowed with Web-Server SandBox Applied to Audit Fileless Attack
Authors: Lima Sidney , Silva Sthéfano , Pinheiro Ricardo , Souza Danilo , Lopes Petrônio , Lima Rafael , Oliveira Jemerson , Monteiro Thyago , Fernandes Sérgio , Albuquerque Edison , Silva Washington , Santos Wellington 
Published: February 2022

Abstract
Background and Objective: Almost all malwares running on web-server are php codes. Then, the present paper creates a NGAV (Next Generation Antivirus) expert in auditing threats web-based, specifically from php files, in real time. Methods: In our methodology, the malicious behaviors, of the personal computer, serve as input attributes of the statistical learning machines. In all, our dynamic feature extraction monitors 11,777 behaviors that the web fileless attack can do when launched directly from a malicious web-server to a listening service in a personal computer. Results: Our NGAV achieves an average 99.95% accuracy in the distinction between benign and malware web scripts. Distinct initial conditions and kernels of neural networks classifiers are investigated in order to maximize the accuracy of our NGAV. Conclusions: Our NGAV can supply the limitations of the commercial antiviruses as for the detection of Web fileless attack. In opposition of analysis of individual events, our engine employs authorial Web-server Sandbox, machine learning, and artificial intelligence in order to identify malicious Web-sites.
Effects of COVID-19 Pandemic on Progress Test performance in German speaking countries.
Authors: Berlin Progress Test Medizin Charité Universitätsmedizin , Sehy Victoria , Atanet Iván Roselló , Sieg Miriam , Struzena Jana , März Maren 
Published: February 2022

Abstract
Background The COVID-19 pandemic has been the source of many challenges for medical students worldwide. The authors examined short-term effects on the knowledge gain of students in German speaking countries. Method The development of the knowledge gain of medical students during the pandemic was measured comparing the outcomes of shared questions within Berlin Progress Test (PT) pairs. The PT is a formative test of 200 multiple choice questions at graduate level, which provides feedback to students on knowledge and knowledge gain during their course of study. It is provided to about 11,000 students in Germany and Austria around the beginning of each semester. We analysed three successive test pairs: PT36-PT41 (both conducted before the pandemic), PT37-PT42 (PT37 took place before the pandemic; PT42 was conducted from April 2020 onwards) and PT38-PT43 (PT38 was administered before the pandemic; PT43 started in November 2020). The authors used mixed-effect regression models and compared the absolute variations in the percentage of correct answers per subject. Results The most recent test of each PT-pair showed a higher mean score compared to the previous test in the same pair (PT36-PT41: 2.53 (95% CI: 1.31-3.75), PT37-PT42: 3.72 (2.57-4.88), PT38-PT43: 5.66 (4.63-6.69)). Analogously, an increase in the share of correct answers was observed for most medical disciplines, with Epidemiology showing the most remarkable upsurge. Conclusion: Overall, PT performance improved during the pandemic, which we take as an indication that the sudden shift to online learning did not have a negative effect on the knowledge gain of students. We consider that these results may be helpful in advancing innovative approaches to medical education
Comprehensive Analysis of the Prognosis of S100 Family Members and Their Relationship with Tumor-Infiltrating Immune Cells in Human Pancreatic Adenocarcinoma
Authors: Ren Yajun , Chen Bing , Zhang Meng , Xu Feng 
Published: February 2022

Abstract
Background: S100 family members(S100s) are small molecular EF hand calcium binding proteins and widely expressed in many tissues and organs. S100s are shown to be biomarkers of disease progression and prognosis in various types of cancers. Nevertheless, the expression patterns, function, prognostic values of S100s and its association with tumor-infiltrating immune cells in Pancreatic Adenocarcinoma(PAAD) patients have not been systematically clarified. Methods: we explored that the expression and roles of the entire twenty S100s in PAAD patients by using the following public databases: Oncomine, GEPIA, cBioPortal, Metascape, STRING, TIMER and GeneMANIA.Results: The S100A2/A3/A4/A6/A8/A9/A10/A11/A13/A14/A16/B/P mRNA expression were significantly upregulated in PAAD patients. The mRNA expression of S100A3/A4/A5/A6/A10/A11/A14/A16/Z were significantly negatively related with the tumor stage in PAAD patients. We found that the S100A2/A3/A5/A10/A11/A14/A16 were significantly correlated with poor OS, whereas the increased levels of S100A1/B/G/Z were strongly associated with good OS. We found significant correlations among S100s and Tumor-Infiltrating Immune Cells. Cox proportional risk models revealed that B cells, Dendritic cells and S100A1/A5/A6/A8/A9/A13/A14 were significantly related with outcomes in PAAD patients. Conclusions: S100A2/A3/A10/A11/A14/A16 may serve as new diagnostic and prognostic biomarkers for PAAD patients and provide new clues for immunotherapy in PAAD patients.
Research progress on meibomian gland dysfunction from 2011 to 2020: a bibliometric and visualized analysis
Authors: Liu Qian , Zhao Fangkun , Kong Jun 
Published: February 2022

Abstract
Purpose: To explore the research areas, hotspots, and progress of meibomian gland dysfunction through bibliometrics.Methods: Related publications were retrieved from the Web of Science Core Collection from 2011 to 2020. VOSviewer1.6.16, Citespace.5.7. R2, and GraphPad Prism 8 were used to visualize the distribution of countries, research institutions, journals, authors, keywords, and annual publication numbers in this field.Results: A total number of 716 relevant publications were retrieved. The United States and Keio University ranked the first among the countries and organizations with the most publications. Cornea, Investigative Ophthalmology & Visual Science, and Ocular Surface were the top three journals with the highest publication counts and citations. The authors who contributed to this topic mainly formed three clusters which manifested the research areas, and the extracted keywords mainly formed four clusters which manifested the hotspots were explored. The research areas and hotspots of meibomian gland dysfunction were as follow: (1) Pathogenesis or potential etiology of meibomian gland dysfunction; (2) Diagnosis of meibomian gland dysfunction; (3) Therapy of meibomian gland dysfunction and the International Workshop`s dedication to it; (4) Epidemiology of meibomian gland dysfunction.Conclusions: In the last ten years, hundreds of publications revealed that the pathogenesis, diagnosis, epidemiology, and therapy were the research hotspots in meibomian gland dysfunction research area.
Multiscale Attribution Analysis of Urban Flood
Authors: Zhang Jinping , Wang Yuhao 
Published: February 2022

Abstract
In order to reveal the influence of the environment on urban flood, the rainfall and flood are decomposed to four components. Then the multiscale model of urban flood is constructed in the Jialu River Basin in Zhengzhou city of China. The results show that the underlying surface is the main driver of urban flood. Moreover, rainfall and flood volume basically retain a linear relationship in the first three components, and the impact of underlying surface is mainly reflected in a3. The multiscale model has good simulation effect and prediction effect.