bluuebunny/crossref_metadata_2025_split huggingface dataset:
Z-RNA and the flipside of the SARS Nsp13 helicase
Authors: Herbert Alan , Poptsova Maria 
Published: April 2022

Abstract
We present evidence that the severe acute respiratory syndrome coronavirus (SARS) non-structural protein 13 (Nsp13) modulates the Z-RNA dependent regulated cell death pathways [1]. We show that Z-prone sequences (called flipons [2]) exist in coronavirus and provide a signature (Z-sig) that enables identification of the animal viruses from which the human pathogens arose. We also identify a potential RIP Homology Interaction Motif (RHIM) in the helicase Nsp13 that resembles those present in proteins that initiate Z-RNA-dependent cell death through interactions with the Z-RNA sensor protein ZBP1. These two observations allow us to suggest a model in which Nsp13 down regulates Z-RNA activated innate immunity by two distinct mechanisms. The first involves a novel ATP-independent Z-flipon helicase (flipase) activity in Nsp13 that differs from that of canonical A-RNA helicases. This flipase prevents formation of Z-RNAs that would otherwise activate cell death pathways. The second mechanism likely inhibits the interactions between ZBP1 and the Receptor Interacting Proteins Kinases RIPK1 and RIPK3 by targeting their RHIM domains. Together the described Nsp13 RHIM and flipase activities have the potential to alter the host response to coronaviruses and impact the design of drugs targeting the Nsp13 protein. The Z-sig and RHIM domains may provide a way of identifying previously uncharacterized viruses that are potentially pathogenic for humans.
Multimorbidity among Inflammatory Bowel Disease Patients in a Tertiary Care Center: A Retrospective Study
Authors: Mosli Mahmoud , Alsahafi Majid , Alsanea Mohammad N , Alhasani Faisal , Ahmed Mohammad Salah , Saadah Omar 
Published: April 2022

Abstract
Background and ObjectivesInflammatory bowel disease (IBD) is a chronic systemic inflammatory condition that debilitate the quality of life. Multimorbidity, a concept only beginning to emerge in IBD, is defined as two or more comorbidities present in the same individual. Multimorbidity is linked to decreased quality of life, poorer disease outcomes, increased hospitalizations, healthcare costs and polypharmacy complications. We aim to estimate the prevalence of multimorbidity and to explore its impact on IBD patients.MethodsWe retrospectively reviewed all IBD patients registered in a validated web-based registry since February 2018. Data on patient demographics, comorbidities, IBD and extraintestinal complications were obtained. We analyzed the date using univariate and bivariate analysis.ResultsAmong 767 IBD patients, 54.6% had Crohn’s disease (CD), 41.9% had ulcerative colitis (UC) and 3.5% had IBD unclassified. The median age at diagnosis was 22 years (IQR: 15–29). Males compromised 50.2% of patients. According to the Montréal IBD classification, most UC patients had moderate UC (47.8%) while most CD patients had non-stricturing non-penetrating CD (49.8%). Overall, 10.3% IBD patients had multimorbidity and 23.9% had at least one comorbidity. The most common comorbidity was diabetes mellitus (4.9%) followed by essential hypertension (4%) and Iron deficiency anemia (3%). Female gender (P = 0.008) and UC (P = 0.005) were more likely to have multimorbidity. Multimorbid IBD patients were more likely to develop thrombosis than non-multimorbid peers (16.7% vs 1.6%; P < 0.000).ConclusionsMultimorbidity is not uncommon among IBD patients, especially females diagnosed with UC. Our findings indicate that future studies are needed to explore the effects of multimorbidity on IBD patients.
Food insecurity and low social support associated with the absence of breastfeeding in the immediate postpartum period in newborns from high-risk pregnancies.
Authors: Augusto Ana Lúcia Pires , Rodrigues Aléxia Vieira de Abreu , Salles-Costa Rosana 
Published: April 2022

Abstract
Food insecurity (FI) and low social support (SS) can be associated with adverse neonatal health conditions, including weaning at very early stages. Thus, this study aimed to investigate the relationship between FI and low SS in high-risk pregnant women with breastfeeding (BF) at birth. To achieve this goal, between 2017 and 2020, 142 pregnant women at clinical risk and her newborns, at a reference university hospital in the state of Rio de Janeiro were evaluated. In the first prenatal care visit, the household FI ​​situation was measured with the Brazilian Food Insecurity Scale (BFIS) and SS was measured with the Social Support Scale of the Medical Outcomes Study (USA). In addition, sociodemographic and pregnancy-related data and the presence or absence of breastfeeding (BF) on the first day of birth were investigated. To verify the relationship between FI, SS and BF, logistic regression models were used, and the odds ratio (OR) and respective confidence interval (95% CI) were estimated. Those associations with a p value less than 0.05 in the adjusted model were considered significant. A total of 57.1% of pregnant women were found to have FI, and the highest average score of social support was related to the dimension (89.8%). Most newborns received BF together with industrialized formula (46%). FI (OR = 7.1; 95% CI: 1.3–27.7), the existence of disease prior to pregnancy (OR = 6.8; 95% CI: 1.2–28.6), alcohol consumption during pregnancy (OR = 13.9; 95% CI: 1.3–29.5) and newborn respiratory diseases (OR = 25.8; 95% CI: 3.9–50.8) increased the chance for the absence of breast milk consumption at birth. Based on these results, strategies for FI reduction, such as improving conditions of early access to prenatal care to improve gestational health conditions that interfere with breastfeeding, are recommended.
The Influence of Parameters on the Physical Properties of Pure Cellulosic Plain Weave Woven Fabrics.
Authors: Ahmed Shaharia 
Published: April 2022

Abstract
The purpose of this article is to examine the physical characteristics of three different types of 100% cotton 1/1 plain woven fabrics. Fabrics like canvas, poplin, and voile are taken into consideration. These fabrics have a 60-inch width in common. Tear strength, tensile strength, weight (g/m2), cover factor, shrinkage, air permeability, Martindale pilling resistance, and Ultra-Violet Transmission were all tested on the fabrics. The experiments were carried out using the ASTM & AATCC Standards test procedure, which is mentioned further down in this document. In comparison to poplin and voile, canvas cloth has superior weight and strength qualities. In comparison to the other two textiles, voile fabric had a higher value of shrinkage and ultra-violet protection factors (UPF). The air permeability of canvas fabrics is higher. The research is based on exercise, and the findings support textile specialists. Researchers will be able to pursue this field further because of our investigation.
Clinical value and prediction efficiency of Neutrophil-to-lymphocyte radio and D-dimer on admission for functional outcome in patients with cerebral venous sinus thrombosis
Authors: Sun Rui , Yin Ge , Wu Wen , Ding Qichao , Gu Zhengsheng , Fan Cunxiu , Song Chenrui , Liang Meng , Liu Xiaobei , Bi Xiaoying 
Published: April 2022

Abstract
BACKGROUNDS:
Cerebral venous sinus thrombosis (CVST) is a rare subtype of stroke with a variety of clinical manifestations. This study aimed to explore the role of inflammatory factors and the changes of coagulation function at different stage in the prognosis of cerebral venous sinus thrombosis (CVST).
METHODS
We assessed inflammation and coagulation factors in 137 CVST patients over a 12-year period (2010–2021). The short-term functional outcome was evaluated with the modified Rankin Scale (mRS) at discharge. Patients with CVST were divided into two groups, 102 patients with good functional outcome (mRS score 0–2) and 35 patients with poor functional outcome (mRS score 3–6). Binary logistic regression was performed to identify the potential independent risk factors for functional outcome of patients with CVST. The correlation between each indicator and mRS was assessed. We also use receiver operating characteristic curve (ROC) analysis to evaluate the discriminative ability of significant factors in predicting functional outcome.
RESULTS
Significantly higher neutrophil to lymphocyte ratio (NLR) and D-dimer levels on admission were observed in patients with poor outcome. After adjustments, NLR and D-dimer on admission remained a significant predictor for unfavorable functional prognosis in CVST patients (NLR: OR [95% CI] 1.243 [1.059–1.459], p = 0.008; D-dimer: OR [95% CI] 1.177 [1.021–1.356], p = 0.025). ROC curve of a prediction model showed that NLR ≥ 2.105 and D-dimer ≥ 0.845 could better predict the unfavorable outcome at discharge.
CONCLUSIONS
D-dimer and NLR on admission are independent predicators for short-term functional outcome in CVST patients and may be meaningful for better optimizing treatment decisions.
Cancer cell survival depends on collagen uptake into tumor-associated stroma
Authors: Hsu Kuo-Sheng , Dunleavey James , Szot Christopher , Yang Liping , Hilton Mary Beth , Morris Karen , Seaman Steven , Feng Yang , Lutz Emily , Koogle Robert , Tomassoni-Ardori Francesco , Saha Saurabh , Zhang Xiaoyan , Zudaire Enrique , Bajgain Pradip , Rose Joshua , Zhu Zhongyu , Dimitrov Dimiter , Cuttitta Frank , Emenaker Nancy , Tessarollo Lino , Croix Brad St 
Published: April 2022

Abstract
Collagen I, the most abundant protein in humans, is ubiquitous in solid tumors where it provides a rich source of exploitable metabolic fuel for cancer cells. While tumor cells were unable to exploit collagen directly, here we show they can usurp metabolic byproducts of collagen-consuming tumor-associated stroma. Using genetically engineered mouse models, we discovered that solid tumor growth depends upon collagen binding and uptake mediated by the TEM8/ANTXR1 cell surface protein in tumor-associated stroma. Tumor-associated stromal cells processed collagen into glutamine, which was then released and internalized by cancer cells. Under chronic nutrient starvation, a condition driven by the high metabolic demand of tumors, cancer cells exploited glutamine to survive, an effect that could be reversed by blocking collagen uptake with TEM8 neutralizing antibodies. These studies reveal that cancer cells exploit collagen-consuming stromal cells for survival, exposing an important vulnerability across solid tumors with implications for developing improved anticancer therapy.
Object-centered sensorimotor bias of torque control in the chronic stage following stroke
Authors: Schneider Thomas Rudolf , Hermsdörfer Joachim 
Published: April 2022

Abstract
BackgroundWhen lifting objects whose center of mass (CoM) are not centered below the handle one must compensate for arising external torques already at lift-off to avoid object tilt. Previous studies showed that finger force scaling during object lifting may be impaired at both hands following stroke. However, torque control in object manipulation has not yet been studied in patients with stroke.In this study, thirteen patients with chronic stage left hemispheric stroke (SL), nine patients with right hemispheric stroke (SR) and hand-matched controls had to grasp and lift an object with the fingertips of their ipsilesional hand at a handle while preventing object tilt. Object CoM and therewith the external torque was varied by either relocating a covert weight or the handle. The compensatory torque at lift-off (Tcom) is the sum of the torque resulting from 1) grip force being produced at different vertical finger positions (∆CoP x GF) and 2) different vertical load forces on both sides of the handle (∆Fy x w/2).ResultsWhen having to rely on sensorimotor memories, ∆CoP x GF was elevated when the object CoM was on the ipislesional-, but decreased when CoM was on the contralesional side in SL, whereas ∆Fy x w/2 was biased in the opposite direction, resulting in normal Tcom. SR patients applied a smaller ∆CoP x GF when the CoM was on the contralesional side. Torques were not altered when geometric cues were available. The sensorimotor spatial bias of ∆CoP x GF was more pronounced and translated to a bias of overall Tcom in SL patients with signs of apraxia (n = 3). ConclusionOur findings provide evidence for an object-centered spatial bias of manual sensorimotor torque control with the ipsilesional hand following stroke. While both intact finger force-to-position coordination and visuomotor control may compensate for the spatial sensorimotor bias in most stroke patients, it may result in a hampered manual torque control in patients with apraxia.
Does Plate Waste Matter? : A two-stage cluster survey to assess the household plate waste in the Philippines
Authors: Angeles-Agdeppa Imelda , Toledo Marvin , Zamora Jezreel Ann 
Published: April 2022

Abstract
Background
Plate waste is an urgent global research problem. Gaining better knowledge of the quantity and patterns of plate waste among households may give critical insights into resolving the greater problem of unnecessary plate waste. The study was conducted to determine the amount of plate wastage across food security levels of households and evaluate possible factors associated with plate waste.
Methods
This investigation analyzed the data from the 2018 Expanded National Nutrition Survey. Food weighing, food inventory, and food recall were the methods used to collect household food consumption and plate waste. Household Food Insecurity Access Scale was used to identify levels of food security among households.
Results
The present study has revealed that rice-vegetables-fish/meat, or a combination of the two was the usual meal pattern observed among households. Rice, vegetables, and meat were the top 3 most wasted foods among Filipino households. Food secure households wasted more rice, fats and oils, cereals, fish, as well as maize and corn products than food insecure households. Too much meal portion size, greater number of household members and wealth increases the likelihood of rice, vegetable, and meat wastage.
Conclusions
These findings suggest that plate waste is a health policy issue as households are routinely purchasing large amounts of nutritious produce that they are not consuming; and hence, increasing the need for interventions aimed at reducing plate waste among households.
Study on comprehensive evaluation of Environmental pollution treatment effect in coal mine subsidence area: Taking Xinglongzhuang mining area of Yanzhou coal industry as an example
Authors: Han Xiuyan , Guo Pengyuan , Sun Fengqi 
Published: April 2022

Abstract
In order to explore the effective evaluation method of Environmental pollution treatment effect in China's coal mine subsidence areas, based on the literature review and analysis of current situation, combined with the reality of Environmental pollution treatment(EPT) in China's coal mine subsidence areas, this paper selected four categories,including a total of 21 evaluation indicators, and drew lessons from the latest research results in relevant fields to construct the spatial niche suitability model of comprehensive evaluation of Environmental pollution treatment effect in coal mine subsidence area. Taking the collapse area of Xinglongzhuang coal mine of Yanzhou coal industry as an example, the comprehensive evaluation and application of Environmental pollution treatment effect in coal mine subsidence area were studied. It is found that the Environmental pollution treatment effect of the mining area has increased from moderate pollution (level III) in 2012 to mild pollution (Level I) in 2020 within nine years. The Environmental pollution treatment effect has a rapid improvement relatively, but its growth rate has decreased year by year since 2016, and the environmental pollution indicator is still at a high level. Therefore, Environmental pollution treatment in the subsidence area is still a long-term task of Dongtan coal mine. The research results of this paper provide an effective quantitative analysis method for the evaluation of Environmental pollution treatment effect in coal mine subsidence area, which is conducive to the continuous improvement of Environmental pollution treatment effect in mining area.
Targeting Akt/PI3K /mTOR signaling pathway for complete eradication of keloid disease by sunitinib
Authors: Chen Yiqing , Chen Chunlin , Fang Junren , Su Kui , Yuan Qian , Hou Huan , Xin Huijuan , Sun Jianwu , Huang Chaohong , Li Shuyi , Yuan Zhengqiang , Luo Shengkang 
Published: April 2022

Abstract
Keloid disease is a nodular lesion, tumor-like but not cancerous, and characteristic of excessive proliferation of fibroblasts and deposition of extracellular matrix (ECM) components. This condition often causes itching, pain and cosmetic disfigurement, significantly reducing the quality of life in patients. To date there are no universally effective therapies available possibly due to the lack of good understanding of pathogenesis of keloid scarring. As an oral small-molecule inhibitor of some tyrosine kinase receptors, sunitinib has shown significant therapeutic effects in renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST). However, it has never been tested if keloid therapy can be effective for the management of keloids. This study thus aims to explore the potential of sunitinib for keloid treatment. Keloid-derived fibroblasts (KFs) were successfully isolated and cultured and they demonstrated proliferative advantage to normal skin-derived fibroblasts (NFs). Additionally, sunitinib showed specific cytotoxicity and inhibition of invasion, and induced cell cycle arrest and significant apoptosis in KFs. These effects were accompanied with complete suppression of ECM component expression including collagen type-1 and − 3, and significant downregulation of the Akt/PI3K/mTOR pathway. Moreover, a keloid explant culture model was successfully established and used to test the therapeutic efficacy of sunitinib on keloid in nude mice. Sunitinib was found to induce complete regression of keloid explant fragments in nude mice, showing significantly higher therapeutic efficacy than the most commonly used intralesional drug triamcinolone acetonide (TAC). These data suggest that sunitinib effectively inhibits keloid development through suppression of the Akt/PI3K/m-TOR pathway, and thus can be potentially developed as a monotherapy or combination therapy for the effective treatment of keloid disease.
Mediating role of impaired wisdom in the relation between childhood trauma and psychotic-like experiences in Chinese college students: a nationwide cross-sectional study
Authors: Zhang Jiamei , Liu Zhening , Long Yicheng , Tao Haojuan , Ouyang Xuan , Wu Guowei , Chen Min , Yu Liuyu , Zhou Liang , Sun Meng , Lv Dongsheng , Cui Guangcheng , Yi Qizhong , Tang Hong , An Cuixia , Wang Jianjian , Wu Zhipeng 
Published: April 2022

Abstract
Background.
The association between childhood trauma (CT) and psychotic-like experiences (PLEs) is well-established. Many previous studies have recognized wisdom as a protective factor for mental health, but its role in the relation between CT and PLEs remains unknown. We aimed to investigate the mediating effect of wisdom in the above association among Chinese college students.
Methods.
We conducted a nationwide survey covering 9 colleges across China and recruited a total of 5873 students using online questionnaires between September 14 and October 18, 2021. Convenience sampling was adopted. We employed the San Diego Wisdom Scale (SD-WISE), the Childhood Trauma Questionnaire (CTQ-28), and the 15-item Positive Subscale of the Community Assessment of Psychic Experiences (CAPE-15) to measure the wisdom, CT and PLEs, respectively. Descriptive, correlation, and mediation analysis were utilized.
Results.
The positive correlation between CT and PLEs was well-replicated among college students (Pearson’s r = 0.30, p < 0.001). Wisdom was negatively associated with CT (Pearson’s r=-0.46, p < 0.001) and frequency of PLEs (Pearson’s r=-0.25, p < 0.001). Total wisdom score partially mediated the relationship between cumulative childhood trauma, neglect, abuse and PLEs, separately. The mediated model respectively explained 21.9%, 42.54% and 18.27% of the total effect of CT on PLEs. Our model further suggested that childhood trauma could be related to PLEs through decreasing the following wisdom components: decisiveness, emotional regulation and prosocial behavior.
Conclusions.
For the first time, our results suggested that impaired wisdom played a role in the translation from childhood adversity to subclinical psychotic symptoms, implicating wisdom as a possible target for early intervention for psychosis among young individuals. Longitudinal work is warranted to verify the clinical implications.
Parametric Quintic Spline for Time–Fractional Burger’s and Coupled Burgers’ Equations
Authors: Hammad D.A , Semary Mourad S. , Khattab Ahmed G. 
Published: April 2022

Abstract
In this paper, the solutions of time–fractional Burger’s equation and time–fractional coupled Burgers’ equations are obtained using the parametric quintic spline method with a local truncation error of order eight. Moreover, the stability analysis of the present method is demonstrated using Von–Neumann method. Also, to show the accuracy of this method, some examples with different cases for Burger’s and coupled Burgers’ equations are presented and compared with the previous methods.
Removal of Cefotaxime Antibiotics from Hospital Wastewater using TiO2 and SiO2 Nanoparticles-Modified Polyethersulfone Membrane: Experimental and Computational Study
Authors: Nikfarjam Zeinab , Heravi Mohammad Momen , Bozorgmehr Mohammad Reza 
Published: April 2022

Abstract
Antibiotics may be regarded as novel and harmful contaminants in the ecosystem because of their increased usage worldwide and presence in wastewater, endangering people's health and the environment even in small amounts. Among the adverse effects of the compounds are drug resistance and alteration in biological cycles. The present study aims to remove one of the cephalosporin antibiotics (cefotaxime) from hospital wastewater using synthetic modified membranes containing nanoparticles based on the in vitro and molecular dynamics (MD) simulation study. To do so, first, Polyethersulfone (PES) polymeric membrane, silicon dioxide (SiO2), and titanium dioxide (TiO2) nanoparticles were synthetic in the practical phase. Then, the impact of different factors, including pH, concentration, and contact time, was examined on the efficiency of wastewater treatment. Thermodynamic studies were also conducted to identify and analyze the adsorption isotherms of the PES polymeric membrane. The results indicate that the PES polymeric membrane achieved the maximum surface adsorption at 37 ° C, 180 min contact time, and pH = 5. The simulations were performed using Materials Studio and LAMMPS molecular dynamics simulator. The efficiency of simulations was assessed when the boundary conditions and force field were determined. At various temperatures, the best operating temperature, adsorption isotherms, and membrane morphology have all been studied. The adsorption isotherms were determined on the membrane surface in a low-pressure range from 1 kPa to 10000 kPa and at three different temperatures 21°C, 28°C, and 37°C. According to the results, the adsorption rate of cefotaxime on the membrane at 21°C and 28°C is approximately 2.6 times the adsorption rate at 37°C and a pressure of 1 kPa. The distribution of molecules at the given temperatures, the position of the occupied membrane, and the membrane cavities for trapping cefotaxime molecules were all observed in the analysis of the density of cefotaxime adsorbed on the membrane surface. Finally, a good agreement was achieved between the simulation and experimental results for wastewater treatment.