bluuebunny/crossref_metadata_2025_split huggingface dataset:
KRİPTO PARALARIN MUHASEBE VE RAPORLAMA SİSTEMİNDE GÖSTERİMİ
Authors: BİNİCİ Fatih Ömür , ASLAN Yakup 
Published: March 2022

Teknolojide yaşanan dönüşüm, finansal varlıklar üzerinde etkili olmuştur. Blockchain teknolojisi, finansal enstrümanlar arasında sanal varlık kalemlerinin ortaya çıkmasını sağlamıştır. Günümüzde sanal varlık denildiğinde kripto paralar akla gelmektedir. Kripto paraların, merkeziyetsiz finansın doğal çıktıları olması, nitelik olarak erişimin kolaylığı, erişimde maliyetlerin diğer finansal enstrümanlara göre çok uygun olması kripto paraların popülaritesini artırmıştır. Esasen kripto varlıkların, herhangi bir otoriteye bağlı olmadan değerlendirilmesi, yasal olmayan her türlü mal ve hizmetim alım satımına olanak tanımaktadır. Bu durum merkezi finans sistemini, mali sistemi kimi zaman tehdit edebilmektedir. Kara para aklama, kanunsuz mali ticaretin sürdürülmesi gibi yolsuzluklara sebebiyet vermektedir. Kripto paraların muhasebeleştirilmesi, kayıt altına alınması, bahsedilen olumsuzlukların yaşanmasına engel olacaktır. Özellikle kripto paraların doğalarında olan kuralsız temelli yaklaşımın küresel ticarette yaratacağı sorunlar, özenle değerlendirilerek gerekli regülasyonların ivedilikle yapılması gereklidir.
Çalışmada kripto varlıkların kavramsal çerçevesi, teknik ve hukuki altyapısı açıklanacaktır. Literatürde kripto paraların muhasebe ve raporlanması ile ilgili kanıtlar sunulacaktır. Kripto paraların muhasebeleştirilmesi ve raporlanması konularının, Uluslararası Muhasebe Standartları açısından değerlendirilerek, kripto varlıklarının takibi konusunun gerekliliği vurgulanacaktır.
Perinatal Outcome in Term Pregnancy with Isolated Oligohydramnios: Retrospective Observational Study
Authors: Adhikari Ayushma , Gurung Tika Kumari , Adhikari Shree Prasad 
Published: March 2022

Introduction: Isolated Oligohydramnios complicates 3 to 5% of pregnancy at term both in terms of fetal outcome and mode of delivery.
Aims: To study the perinatal outcome in isolated oligohydramnios (Amniotic Fluid Index≤8) and compare the outcome between Borderline (Amniotic Fluid Index=5.1-8 cm) and Severe (<5 cm) oligohydramnios.
Methods: Retrospective observational study of pregnancy outcome with isolated oligohydramnios (Amniotic Fluid Index≤8 cm) at term was carried out in Gandaki Medical College Teaching Hospital, Pokhara for one year from January 2019 to December 2019. Patients were divided into Borderline Oligohydramnios (Amniotic Fluid Index=5.1 to 8 cm) and Severe Oligohydramnios (Amniotic Fluid Index ≤5 cm). The two groups were compared in terms of fetal outcome like: meconium passage, low birth weight, low APGAR (Appearance, Pulse, Grimace, Activity and Respiration) score at 1 and 5 min, Neonatal Intensive Care Unit (NICU) admission and neonatal death. Similarly mode of delivery was also compared.
Results: There were total of 100 patients with isolated oligohydramnios. Of which 51(51%) were with Borderline Oligohydramnios and 49(49%) with Severe Oligohydramnios. The incidence of adverse perinatal outcome and caesarean delivery was high in patients with isolated oligohydramnios. When compared with the two groups there was significant difference in terms of meconium passage (11% vs 48.9%), low birth weight (5.8% vs 18%), low APGAR (Appearance, Pulse, Grimace, Activity and Respiration) score at 1 min (1.9% vs 14%), NICU (Neonatal Intensive Care Unit) admission (11% vs 67%) and Caesarean delivery (39% vs 79.5%).
Conclusion: Isolated oligohydramnios at term has been associated with an increased risk for caesarean delivery for fetal distress and adverse perinatal outcomes. Severe oligohydramnios is a sensitive predictor for the adverse perinatal outcome both in terms of fetal outcome and termination of pregnancy.
In vitro Evaluation of Tinidazole Bioadhesive Vaginal Gels
Authors: T.Salih Zainab 
Published: March 2022

Many trials were made to prepare Tinidazole 2% as bioadhesive vaginal gels using different gel bases including hydroxypropyl methyl cellulose (3 and 4% w/w), methylcellulose (3 and 4%w/w) and carboxymethylcellulose (2 and 3% w/w) .Swelling index of the polymers,pH , viscosity , bioadhesive force , and in-vitro drug release to the simulating vaginal fluid (S.V.F.) were investigated for all the prepared bioadhesive gels . The mechanism of drug release from the gel bases was also investigated.
The results revealed that C MC 3% gave the highest viscosity and bioadhesive strength with the lowest release rate while lowest viscosity and bioadhesive force was obtained with HPMC gel base with the highest release rate. The mechanism of drug release was affected by the type of gel base. Fickian diffusion was obtained with all gel bases.
Key words: Tinidazole, bioadhesive polymers, gels
Urine Protein SDS-PAGE Reveals Different Profiles in Iraqi Children with Kala-azar
Authors: MK Al-Mulla Hummadi Yassir 
Published: March 2022

Urine proteomics have been an area of interest and recently in Kala-azar as an alternative sample type for serum or plasma. Because of simplicity, noninvasiveness of collection and simpler matrix. Many studies had detected an increased protein excretion in the urine of patients with active Kala-azar due to renal involvement particularly by an immunological related mechanism(s). This study have demonstrated the presence of three different protein profiles in Iraqi children (Patients: including 60 children aged 4-60 months) with defined Kala-azar using the conventional SDS-PAGE on urine samples. Urine protein profile in Kala-azar patients revealed three groups of banding patterns: group-1(33.4)% of the patients show the pattern of 5 bands with a MW. Ranged (512.861-158.489), groups-2, 3 were (55, 11.6) % of the patients showing 2 banding proteins with a MW. ranged (512.861-199.526) , (199.526-181.97) respectively. These findings may be correlated with other epidemiological studies that revealed the presence of different clinical presentations like fever, spleenomegally, hepatomegally, thrombocytopaenia, and different response to leishmania therapy. Furthermore, the presence of different protein patterns may also be related to the chronicity of infection and the degree of renal involvement. The presence of a similar protein band between group-1 and 2 may be of diagnostic purpose and further studies on expanded number of patients are required to identify that kind of protein or other urine protein profiles.
Key words: Protein band, protein pattern, sodium dodecyl sulphate-poly acrylamide gel electrophoresis (SDS-PAGE), urine proteome, visceral leishmaniasis.
PENGGUNAAN METODE KOOPERATIF JIGSAW DALAM MENINGKATAKANAKTIVITAS PEMBELAJARAN PAI DI KELAS IV SDN 34 VII KOTO SUNGAI SARIK KABUPATEN PADANG PARIAMAN
Authors: Karnawilis Karnawilis 
Published: March 2022

Kondisi pembelajaran di Sekolah Dasar (SD) khususnya PAIdi sebuah sekolahsering kaliterjebak dengan metode konvensional (metode Ceramah). Dalam pembelajaran sehari-hari, peserta didik pasif dan tidak diaktifkan, sehingga potensinya kurang tergali. Dengan demikiankerativitas dan pola pikir siswa tidak berkembang. Pembelajaran PAI dengan penggunaan metode Cooperativ Jigsaw di kelas IV SD sangat baik untuk diterapkan. Hal tersebut bertujuan agar siswa mampu berbagi informasi, mempunyai sikap menghargai orang lain, kreatif, belajar kekompakan serta mampu bergaul dalam lingkungan kelompok kecil maupun kehidupan sosial nantinya.
Dari studi awal/pra Siklus diperoleh data bahwa aktifitasbelajar siswa kelas IV SD Negeri 34 VII Koto Sungai Sarik Padang Pariaman relatif rendah, hal ini disebabkan oleh penggunan metode yang kurang tepat dan kurang berfariasi. Oleh karena itu maka penulis melakukan penelitian pada mata pelajaran PAI dengan menggunakan metode cooperativ Jigsaw.
Setelah dilakukan perbaikan pembelajaran didapatlah data signifikanterhadap peningkatan aktifitas belajar siswa dalam pembelajaran dengan menggunakan metode Jigsaw. Indikasi ini terlihat dengan peningkatan keaktifanselama pembelajaran yang dicapaipeserta didik. Pada siklus I mendapatkan hasil dengan hasil rerata33%. Ketikaproses pembelajaran berlangsung pada siklus keIVada kemajuanyang signifikan dengan jumlah68%. Disamping itu pada fase perencanaan pembelajaran, kemampuan gurupun makin meningkat. Hal ini terlihat dari (1) RPPmakin membaik, (2) RPP dirancang sedemikian rupasesuai dengan kurikulum 2013yang sangat peka terhadap minat, bakat dan tuntutan kebutuhan siswa, (3) rencana pelaksanaan pembelajaran dibuatdengan mengorganisasikan pemberian tugas secara jelas dan rinci yang tentungan sangat mendukung tercapainya tujuan pembelajaran.
СУЧАСНА ДИСКУРСОЛОГІЯ: СОЦІОЛІНГВІСТИЧНИЙ АСПЕКТ
Authors: Romanchuk S. , Grinenko I. 
Published: March 2022

<p><strong><em>The purpose </em></strong><em>of the article is to reveal discourse as a complex phenomenon that «permeates» various scientific planes.</em></p><p><strong><em>Research methods. </em></strong><em>During the study, the following methods were used: descriptive (to indicate theoretical background); analysis and synthesis, structural (to summarize and systematize the data obtained).</em></p><p><strong><em>Results.</em></strong><em> </em><em>In particular, the authors draw attention to the linguistic and social parameters of discourse understanding. Particular role in the article is given to discourse analysis as a sign of the language code, immersed in the social environment. It is defined as an interdisciplinary field of knowledge, based on sociology, psychology, development of artificial intelligence, ethnography, semiotics, stylistics, philosophy. The paper also analyzes the reasons for the diversity of approaches to sociological analysis of discourse, approaches to the study of the problem of interpretation of the concept of «discourse», delimits the meaning of the terms «text», «discourse», «speech», clarifies the categories, units and structure of discourse, and describes some its typological features.</em></p><p><em>In the article, the authors emphasize the nature of discourse, which is related to two aspects – pragmatic and cognitive. Next, they substantiate the psycholinguistic parameters of discourse. In particular, two points of view are characterized: 1) proper linguistic, that is, discourse as a result; 2) linguocognitive, that is, discourse as a process.</em></p><p><strong><em>Novelty. </em></strong><em>The scientific novelty of the work is to uncover the sociolinguistic vectors of discourse through the prism of its psycholinguistic parameters.</em></p><p><strong><em>Practical significance</em></strong><em>. </em><em>The results of the study can be used in complex studies of the sociological and psychological nature of discourse and in the training of sociologists, psychologists and journalists.</em></p><p><strong><em>Key words:</em></strong><em> discourse, discourse analysis, text, speech, sociolinguistics.</em></p>
РИТОРИЧНІ АСПЕКТИ КОМУНІКАТИВНОЇ ЕФЕКТИВНОСТІ РАННЬОХРИСТИЯНСЬКИХ АПОЛОГІЙ
Authors: Butyrina M. , Babenko Ye. 
Published: March 2022

<p><strong><em>The purpose</em></strong><em> of the study is to identify the rhetorical techniques that are able to ensure effective religious communication.</em></p><p><strong><em>Research methodology</em></strong><strong><em>.</em></strong><em> </em><em>The </em><em>study</em><em> used </em><em>general scientific methods of analysis, synthesis, as well as special scientific method of communication analysis, which allowed to identify the communication means of effective religious speech, to interpret the interaction of the Church with parishioners and other target audiences in </em><em>social communications’ </em><em>term</em><em> system</em><em>. In addition, specific</em><em>-</em><em>historical and cultural</em><em>-</em><em>historical approaches were used for a relevant interpretation of the context of the religious communication which is investigated in the article.</em></p><p><strong><em>Results</em></strong><strong><em>.</em></strong><em> In the study the phenomenon of religious communication is considered and one of the main factors of its effectiveness is identified.</em><em> </em><em>The object of study</em><em> is the early Christian Apologies (First and Second) of Justin the Philosopher, dating from the middle of the second century A.D.</em><em> </em><em>Using this example, we described the context of creating apologies and their effectiveness for the polytheistic world</em><em>, </em><em>found a communicatively effective construction of a religious missionary text and found that it was created in accordance with the traditional rhetorical pattern (treatises of Cicero) in compliance with the basic rules of oratory. Research has shown that the use of rhetorical techniques and, above all, the inculturation approach has been inherent in religious communication since ancient times.</em></p><p><strong><em>Novelty</em></strong><strong><em>.</em></strong><em> For the first time the early Christian apologies were considered as a part of effective religious communication, worthy of imitation in the period of mediatisation of religion, through the prism of the communication approach and the rhetorical canon related to it.</em></p><p><strong><em>Practical significance</em></strong><strong><em>.</em></strong><em> The results and conclusions of the study can complement the scientific discourse of the «Social Communications»</em><em> </em><em>field, as well as be used in teaching disciplines of the «Journalism» specialty in terms of mediatisation of religion.</em></p><p><strong><em>Key words</em></strong><strong><em>:</em></strong><em> religious communication, means of communication, rhetorical canon, apologies, mediatisation of religion.</em></p>
КОРПОРАТИВНІ МЕДІА ЯК ІНСТРУМЕНТ РЕАЛІЗАЦІЇ ІНФОРМАЦІЙНОЇ ДІЯЛЬНОСТІ В БІЗНЕСІ
Authors: Baranetska A. 
Published: March 2022

<p><strong><em>The purpose</em></strong><em> of the study is to understand the role and capacity of corporate media in the implementation of information activities of business structures with different groups of the public.</em><em></em></p><p><strong><em>Research methodology. </em></strong><em>During the study of theoretical and methodological base on the peculiarities of corporate media functioning in the modern information space, methods of analysis and synthesis were used; in the process of determining the main directions of information activities in the field of business descriptive method and method of generalization were applied; to reveal the aspects of implementation of business companies information support on practical samples the method of reception was used.</em><em></em></p><p><strong><em>Results.</em></strong><em> The author characterizes corporate media as one of the basic information and communication tools for providing information support to business structures in the process of interaction with people to meet their information needs. The paper reveals modern tendencies in the organization of this type of communications and describes the forms of their realization actualized by modern technological possibilities. Various ways of information support of business companies through the use of corporate media are presented. The study of basic principles of business information support made it possible to identify the powerful potential of corporate media in contact with various groups (external and internal), in forming and maintaining the image of the organization, its reputational (intangible) capital, in implementation of corporate social responsibility (humanization of business), and also in representation of this type of media as an important component of modern integrated marketing communications.</em><em></em></p><p><strong><em>Novelty.</em></strong><em> The novelty of the problem is to understand the specifics of the implementation of information activities through the prism of real practices of corporate media business companies. The study also presents corporate media as an information and communication complex tool for multifunctional information needs of stakeholders.</em><em></em></p><p><strong><em>Practical significance.</em></strong><em> The analysis provides an opportunity to summarize and systematize the main areas of information support through corporate media.</em><em></em></p><p><strong><em>Key words:</em></strong><em> corporate media (press, media, publications), branded periodicals, image, reputation, information support, information activities (business), data support, integrated marketing communications.</em><em></em></p>
Multiband Handset Antenna System for UMTS/LTE/WLAN/Sub-6 5G and mmWave 5G Future Smartphones
Authors: Sabaawi Ahmed M. A. , Younus Karam Mudhafar 
Published: March 2022

In this paper, a new antenna system for rapidly emerging multifunction devices is presented. The proposed antenna system consists of four antenna components each one operating at different frequency bands separately. The designed antennas are isolated and integrated on a single substrate. The first antenna is designed to operate at 1920–2170 MHz covering the UMTS band, whereas the second antenna is proposed for the lower band 5G systems and WiMAX operating within the frequency range of 3.4–4.2 GHz. Furthermore, another antenna is designed to cover the higher band 5G system and the IEEE 820.11a WLAN within the frequency range of 5.1–5.85 GHz. Finally, a 28 GHz bowtie-based MIMO antenna array is designed and simulated for the mmWave future 5G mobile networks. The proposed antennas were designed and simulated by using CST microwave studio. The results showed that all of the proposed antennas exhibited excellent reflection characteristics below −20 dB at the resonant frequency and achieved high radiation efficiency reached 99% in some cases with a peak gain ranging between 4–6 dBi. The proposed antenna system helps smartphones to perform multitasks and achieve a better-quality operation especially with the enormous growth of IoT techniques.
Caracterização e recuperação de áreas com coprodutos de mineração no semiárido da paraíba. Emprego de serrapilheira
Authors: Martins Kyegla Beatriz da Silva , Santos Rivaldo Vital dos , Leite Arliston Pereira , Fernandes Teotônio Lucas Sabino , Morais Gerlanny Vieira de , Medeiros Natielly Cristine Gomes de , Monteiro Mikaella Meira , Sousa Sávio Maciel da Silva 
Published: March 2022

Os diferentes fatores climáticos e as ações humanas desorientadas podem contribuir para o aumento expressivo do processo de degradação. A transposição de serapilheira atua como uma técnica para facilitar a recuperação de áreas degradadas. O objetivo desse estudo foi de promover o processo de recuperação de áreas degradadas por deposição de coprodutos de mineração na região semiárida da Paraíba por meio de espécies nativas do bioma Caatinga e também por meio do uso de ações que permitam recuperar e preservar o bioma, em virtude da exploração dos recursos naturais de forma sustentável. O trabalho foi desenvolvido na área onde eram depositados os coprodutos, no pátio da Empresa Mineração Pedra Lavrada, municipio de Santa Luzia, Paraíba, durante o périodo de agosto/2018 a julho/2019. Inicialmente coletou-se 12 amostras de solo simples, para formar quatro amostras compostas para representar a área, após foram feitas análises físico-químicas do substrato e definu a área mais antiga para instalar o experimento. A serapilheira foi coletada em locais de vegetação nativa. O delineamento utilizado foi o blocos casualizados com quatro repetições e seis tratamentos: testemunha e incorporando 2,5; 5,0; 7,5; 10,0 e 12,5% de serapilheira ao substrato. Mensalmente avaliou-se as variáveis vegetativas, temperatura e umidade do substrato. Não houve interação significativa para umidade entre os tratamentos e meses de condução do experimento. Houve diferenças estatísticas para temperatura entre os meses avaliados. Não houve resultados positivos na germinação de sementes provenientes da serrapilheira incorporada ao substrato. A transposição de serapilheira não foi eficiente durante os meses avaliados, necessitando de maior período de avaliação para resultados mais satisfatórios.
CAR-T Immunotherapy in oncological treatment: literature review
Authors: Azzam Gabriela Barge , Oliveira Edson Gabriel de , Azzam Rimon Sobhi , Menezes-Rodrigues Francisco Sandro 
Published: March 2022

Introduction: Immunotherapies are developed to overcome limitations of conventional cancer therapy through stimulating innate immune response against tumor antigen. Objective: Elaborate a review on CAR-T Immunotherapy (Chimeric T Cell Antigen Receptor) in cancer treatment. Methods: Bibliographic survey of systematic reviews published in PubMed in the last 5 years. Results: 21 studies were selected. Antitumor effect occurs through cell lysis, due to CAR-T lymphocytes release of cytokines. Tumor escape is related to tumor's ability to not expose its Major Histocompatibility Complex (MHC) and/or inability of the adaptive immune system to recognize tumor antigens. These molecular targets may be proteins, carbohydrates, or glycolipids, with CD19 standing out as target of this therapy and in neoplasms as leukemia and lymphoma. Four generations of CARs have been described, which differ in terms of co-stimulatory domains and consequent functional efficiency. The therapy is indicated for cases of recurrence/refractoriness of hematological neoplasms, however applicability in solid tumors has been studied. Adverse events of CAR-T immunotherapy described were: cytokine release syndrome, neurotoxicity, anaphylactic shock, autoimmune reactions, B cell aplasia, tumor lysis syndrome and graft-versus-host disease. Conclusions: CAR-T immunotherapy is a promising therapy against relapsed/refractory cancer. It’s mainly used in leukemias and lymphomas. Choice of dose and generation of CARs should be cautious, considering specific molecular targets of each neoplasm and its presence in healthy tissues, avoiding adverse events.
Efeito antifúngico de α-pineno isolado e em associação com antifúngicos frente às cepas de Candida albicans
Authors: Barros Daniela Bomfim de , Lima Luanna de Oliveira e , Silva Larissa Alves , Fonseca Mariana Cavalcante , Diniz-Neto Hermes , Rocha Walicyranison Plinio da Silva , Beltrão Gheorgia Victoria de Medeiros , Castellano Lúcio Roberto Cançado , Guerra Felipe Queiroga Sarmento , Silva Márcia Vanusa da 
Published: March 2022

Causada por fungos do gênero Candida spp., a candidíase é relatada como problema de saúde pública, ocasionando infecções superficiais e sistêmicas. O aumento de cepas resistentes isoladas e a elevada toxicidade dos antifúngicos convencionais, têm estimulado a busca por alternativas a este cenário, tais como bioprodutos ou compostos isolados, como exemplo, os terpenos. Desta maneira, faz-se importante investigar a atividade antifúngica de α-pineno isolado e em associação com antifúngicos frente a cepas de Candida albicans. Para isso foram determinadas a Concentração Inibitória Mínima (CIM) e a Concentração Fungicida Mínima (CFM), pela técnica de microdiluição em caldo do terpeno isolado e o ensaio de associação (checkerboard) entre o α-pineno e antifúngicos, como fluconazol e anfotericina B. O α-pineno apresentou uma CIM entre 128 e512 µg/mL e a CFM teve os mesmos valores de CIM frente às cepas 8 cepas ensaiadas. As demais concentrações não foram possíveis determinar a CFM, devido ao crescimento fúngico ser maior ou igual a CIMx4 (limite do teste). No ensaio de associação, a interação α- pineno e fluconazol foi indiferente, já as combinações entre α-pineno com a anfotericina B e a nistatina obtiveram efeitos sinérgicos. Assim, este estudo fortalece o α-pineno como um promissor agente antifúngico, pois este exibiu forte atividade inibitória frente a cepas de Candida albicans., com natureza fungicida. Adicionalmente, há a possibilidade deste ser utilizado de forma associativa aos derivados poliênicos (anfotericina B ou nistatina) como alternativa no tratamento da candidíase. Deve-se destacar que mais estudos precisam ser realizados acerca do mecanismo de ação e toxicidade deste composto.