bluuebunny/crossref_metadata_2025_split huggingface dataset:
Body Models of Law Enforcement Officers for Cruiser Cab Accommodation Simulation
Authors: Hsiao Hongwei , Kau Tsui Ying , Whisler Richard , Zwiener Joyce 
Published: November 2022

Objectives This study developed multivariate law enforcement officer (LEO) body models for digital simulation of LEO accommodation in police cruiser cabs. Background Anthropometrically accurate digital LEO body models, representing the United States LEOs, for computerized LEO cruiser interface simulations are lacking. Methods Twenty body dimensions (with and without gear combined) of 756 male and 218 female LEOs were collected through a stratified national survey using a data collection trailer that traveled across the US. A multivariate Principal Component Analysis (PCA) approach was used to develop digital LEO body models. Results Fifteen men and 15 women representing unique body size and shape composition of the LEO population were identified. A combined set of 24 male and female models (removal of 6 redundant models for which female and male models overlapped) is suggested. Conclusions A set of 24 digital LEO body models in 3-dimensional form, along with their anthropometric measurements, were developed to facilitate LEO cruiser cab design. Application Digital modeling software developers can use the models and their anthropometric data to build digital avatars for simulated evaluation of LEO cruiser cab configuration, console communication-equipment fitting, and cruiser ingress/egress access arrangement. LEO vehicle and equipment designers also can use eight key body dimensions (i.e., stature, buttock-popliteal length, eye height sitting, knee height sitting, shoulder-grip length, popliteal height, sitting height, and body weight) of the body models to recruit 24 human subjects to physically evaluate their vehicle prototypes for improved vehicle and equipment design.
Changes in household debt due to COVID-19 and mental health concerns among adults in Ontario, Canada
Authors: Nigatu Yeshambel T , Elton-Marshall Tara , Hamilton Hayley A 
Published: November 2022

Background:Canadian households experienced unexpected changes in their economic well-being during the COVID-19 pandemic. The extent of the impact of the pandemic on household debt and its effect on health and mental health remains unknown.Aim:The aim of the study was to examine the associations of change in household debt due to COVID-19 with serious psychological distress (SPD) and general health measures.Methods:Data were from the 2020 Monitor study, a repeated cross-sectional survey of adults 18 years and older in Ontario, Canada. The 2020 cycle employed a web-based panel survey of 3,033 adults. The survey included measures of change in household debt due to the COVID-19 pandemic, mental and general health. Odds ratios (OR) were estimated from logistic regression models accounting for sociodemographic factors.Results:Overall, 17.5% of respondents reported that their household debt increased due to the COVID-19 pandemic. Such an increase in household debt was significantly associated with SPD (OR = 2.92, 95% CI, 2.05–4.16), fair/poor mental health (OR = 2.02, 95% CI, 1.59–2.56), frequent mental distress days (OR = 1.80, 95% CI, 1.31–2.48), fair/poor general health (OR = 1.93, 95% CI, 1.47–2.52), and suicidal ideation (OR = 3.71, 95% CI, 2.41–5.70) after adjusting for potential confounders including education, income and employment.Conclusions:Household debt during the COVID-19 pandemic is an important determinant of health. Individuals who reported an increase in household debt due to COVID-19 were more likely to report serious mental health concerns including suicidal ideation. This suggests that debt-related interventions may be needed to alleviate the adverse effects of indebtedness on health.
Estimating the Number of Teachers of Students With Visual Impairments in the United States
Authors: Savaiano Mackenzie E. , Shanahan Bazis Pamela , Hebert Michael , Rodgers Derek B. , Bosilevac Madison , Leutzinger Bridget , Thompson Madison 
Published: November 2022

Introduction and Methods We do not have an accurate count of the number of teachers of students with visual impairments working in the field, and it is a difficult number to estimate. As part of a national survey, states were contacted to estimate how many teachers of students with visual impairments are working in the United States and compared to the estimate developed by the National Plan for Training Personnel to Serve Children with Blindness and Low Vision (NPTP) in 2000. Results and Discussion The estimate calculated from this process is very similar to the estimate from NPTP (2000), indicating that there are roughly the same number of teachers of students with visual impairments in the field now as there were 20 years ago.
Professionals in Brazil, Students in the United States: Brazilian Women at Teachers College
Authors: Warde Mirian J. , Rocha Ana Cristina Santos Matos 
Published: November 2022

Background/Context: The article is part of a line of historical studies on training and improvement travels of Brazilian educators to foreign institutions. These studies have recently increased with the introduction of transnational history approaches. Purpose: This article discusses the training travels of seven Brazilian women, carried out centrally in the 1920s, and the impacts of these trips on their professional careers. Among these women were five teachers and two nurses. Research Design: Through historiographical research, personal and institutional documents are the primary sources to reconstruct their professional and intellectual trajectories. Documents from the institutions involved, particularly from Teachers College, Columbia University, were used, and documents belonging to personal collections, such as diaries, letters, and notebooks. Conclusions: The article gathers the intellectual impressions of the seven Brazilian women provoked by their teachers, colleagues, and experiences in the United States, especially the appropriations they made of their experiences abroad and at Teachers College in particular.
Infection following CF-LVAD exchange for non-infectious indications: A systematic review and meta-analysis
Authors: Sukhavasi Amrita , Blazoski Cameron M. , Maynes Elizabeth J. , Wood Chelsey T , Weber Matthew P , O’Malley Thomas J , Rajapreeyal Indranee , Massey H Todd , Tchantchaleishvili Vakhtang 
Published: November 2022

Introduction: Patients on continuous flow left ventricular assist devices (CF-LVADs) often require CF-LVAD exchange. The purpose of this study was to investigate the incidence of infection following CF-LVAD exchange performed for non-infectious indications. Methods: An electronic literature search was performed to identify all studies of patients undergoing CF-LVAD exchange for pump thrombosis or device malfunction. Of 2,698 articles identified, 6 studies with 81 total patients met the inclusion criteria. Cohort-level data were pooled for meta-analysis. Results: Mean patient age was 60 years (95% CI: 41–78), and 74% were male (95% CI: 61–84). Pump thrombosis was the most common indication for exchange in 70% of patients (95% CI: 47–86). Other indications were driveline fracture and electrical malfunction in 21% (95% CI: 5–56) and 12% (95% CI: 4–33) of patients, respectively. Prior to exchange, 95% of patients were on HeartMate II (HM2) LVADs (95% CI: 86–98) and average duration of support for these patients was 27.1 months (95% CI: 9.3–44.8). The majority were placed on a HM2 following exchange (88% (95% CI: 45–98)) versus HM3 (12% (95% CI: 2–55)). Follow-up was an average of 16.4 months (95% CI: 6.8–26.0). Following exchange, 16 of 81 patients developed infection, with pooled mean incidence of 24% (95% CI: 14–38). 30-day mortality was 14% (95% CI: 7–26). Survival at follow-up was 65% (95% CI: 52–76). Conclusions: Infection following CF-LVAD exchange can occur at rates higher than those observed with primary implantation; therefore, effective strategies need to implemented early and consistently to help lower infections rates and help improve outcomes following exchange.
Our Two Climate Crises Challenge: Short-Run Emergency Direct Climate Cooling and Long-Run GHG Removal and Ecological Regeneration
Authors: Baiman Ron 
Published: November 2022

We are facing both a short-term emergency cooling crisis and a long-term greenhouse gas (GHG) draw down planetary ecological crisis. We must address both. The first requires emergency direct cooling, or temporary “triage” or a “tourniquet, for our bleeding planet.” The second requires rapid GHG emissions reductions and draw down and natural planetary regeneration that realistically will take at least a few decades and may take a century or more. Conflating the challenge and opportunity of the second crisis with a response to the first crisis will not produce a rapid and credible global response to the second crisis because of structural economic inequity and fossil fuel dependency that is deeply embedded in the current global economy. Realistically, we need emergency direct climate cooling to address the first crisis and a long-term binding global cap and trade emissions trading system to address the second. The Florin proposal that conditions Stratospheric Aerosol Injection (SAI) direct climate cooling on credible GHG emissions and draw down is a step in the right direction, but omits other direct climate cooling methods and effectively makes the deployment of SAI contingent on a global emissions trading system (ETS) that may not be possible before the deployment of SAI becomes necessary. Rather than conflating our two climate crises, or conditioning the solution of the first on a solution to the second, we need to address both on an emergency basis by putting all options on the table as called for in the Healthy Planet Action Coalition (HPAC) proposal. JEL Classification: Q54, Q55, Q56, Q57, Q58
Concomitant coracoid base fracture and acromioclavicular joint disruption: A series of patients treated with a clavicle hook plate and review of the literature
Authors: Wignadasan Warran , Al-Obaedi Ossama , Chambers Alastair , Lee Marcus , Rajesparan Kannan , Rashid Abbas 
Published: November 2022

Introduction Concomitant acromioclavicular joint (ACJ) disruptions with coracoid base fractures are rare high energy injuries. The management of these injuries can be challenging. The aim of this study is to assess the functional and radiographic outcomes of a retrospective case series of patients presenting with concomitant ACJ and coracoid base injuries managed with a clavicle hook plate with subsequent hardware removal at a later stage. Methods Six patients were identified for inclusion in the study. Radiographic and clinical data were available which allowed for collection of demographic information as well as classification of the fractures. Telephone consultation with patients allowed for collection of functional scores which included the Oxford shoulder score (OSS), QuickDASH (Q-DASH), Euroqol-5 Dimension (EQ-5D) and the SF-12 score. Results All patients were male with a mean age of 39.8 years and a median follow-up period of 34 months. All patients underwent a successful operative procedure with a median time to union of 3.75 months. Good functional outcomes were reported by all patients: mean OSS 45.0, mean Q-DASH 4.8, mean EQ-VAS 82.8 and encouraging SF-12 scores (mean PCS 56.0, mean MCS 56.4). Conclusion The use of a lateral clavicle hook plate can achieve good healing and functional outcomes when managing patients with acromioclavicular joint disruptions associated with a coracoid base fracture.
Culture and Explicitness of Persuasion: Linguistic Evidence From a 51-Year Corpus-Based Cross-Cultural Comparison of the United Nations General Debate Speeches Across 55 Countries (1970-2020)
Authors: Shen Lin 
Published: November 2022

The explicitness of expression or persuasion has been a critical subject of study in cross-cultural studies. The majority of cross-cultural comparisons in this respect, however, have been based on questionnaires and surveys. This study seeks to diversify the methods and validate the results with a corpus-based register analytical approach. Based on the United Nations General Debate Corpus (UNGDC) that comprises comparable multi-cultural speeches, a diachronic comparison (1970-2020) is made between the 2518 speeches (altogether 7,090,221 tokens) of 55 cultures from the East (East, South, and Southeast Asia) and the West (European Union, North America, and Australia) on the dimension ‘explicitness of persuasion’, a synthesized variable operationalized with 6 linguistic features, with the register analytical framework of Multi-Dimensional Analysis (MDA). The potential impacts of the political contexts on the cross-cultural gap in persuasion explicitness are tentatively discussed with the case studies on China and the United States. The results reveal significant difference between the exemplars from the East and the West on the overtness of persuasion, and the gap is generally narrowing down over the 51 years. The quantitative results provide political-setting linguistic evidence for the relevant findings of Hall, Hofstede, and Inglehart & Welzel, and the narrowing gap between cultures from the East and the West in the explicitness of expression points to an open and dynamic view of cultures. This study may offer implications for further research on the cultural styles of political persuasion.
Photodynamic therapy (PDT) as adjuvant treatment to brachytherapy for amelanotic choroidal melanoma
Authors: Pagliara Monica Maria , Sammarco Maria Grazia , Caputo Carmela Grazia , Pafundi Pia Clara , Giannuzzi Federico , Fionda Bruno , Scupola Andrea , Tagliaferri Luca , Rizzo Stanislao , Blasi Maria Antonietta 
Published: November 2022

Purpose To evaluate the effect of photodynamic therapy (PDT) as adjuvant treatment, after brachytherapy, in posterior amelanotic choroidal melanomas. Methods Six patients with posterior amelanotic choroidal melanoma underwent brachytherapy treatment. Tumour response was assessed by fundus examination, fundus photography and A-B scan ultrasonography. The residual tumours were treated with adjuvant PDT performed with infusion of verteporfin intravenously at 6 mg/m2 body surface area. Five minutes after infusion, a 689 nm laser was applied with a light dose of 100 J/cm2 over an interval of 166 s. Results At a median follow-up after brachytherapy of 17.5 months (IQR 16.2–22.5, range 5–42 months), tumours showed a partial reduction of tumour thickness (22.5% as compared to baseline value) and persistent low internal reflectivity at A-B scan ultrasonography. Supplementary photodynamic treatment resulted in complete resolution of the lesion with marked decrease of elevation . Mean decrease in thickness after PDT was 49.9% with respect to previous brachytherapy treatment 22.5% (p = 0.007). The results was achieved within a median period of 4 months (range 2–4 months) after PDT, and there has been no recurrence after a median follow-up of 84.7 months ± 18.7 (range 59 to 107 months). Conclusion Combined treatment of brachytherapy and adjuvant PDT in amelanotic uveal melanoma seems to be favourable with regard to complete and rapid tumour regression.
Evaluation of Genetic Polymorphisms of the Antioxidant Enzymes and Biomarkers of Oxidative Stress in Preterm Neonates With Respiratory Distress Syndrome Receiving External Surfactant
Authors: Sridharan Kannan , Al Jufairi Mona , Hejab Aamal AbdulGhani Mahdi , Al Madhoob Abdulraoof , Al Marzooq Reem , Taha Safa , Jaber Mulla Aljishi Muna , Abdulhadi Ameera , Al Ansari Eman , Ali Masooma Abdulla , Naser Maryam Ali Ahmed , Al Segai Ola , Dunne Kevin 
Published: November 2022

Background: Preterm neonates, particularly extremely preterm, are susceptible to respiratory distress syndrome (RDS) due to surfactant deficiency. Single nucleotide polymorphisms (SNPs) in the antioxidant enzymes influence the balance between antioxidant and oxidative stress molecules. Objectives: To ascertain the role of SNPs of antioxidant enzymes and oxidative stress biomarkers in preterm neonates with RDS. Design: Observational, cross-sectional study. Methods: Preterm neonates diagnosed with RDS receiving external surfactant within 24 hours were considered as the cases and those without RDS were the control group. Umbilical cord blood and peripheral blood samples before administering surfactant (day 1), and on days 2 and 3 were collected. Plasma malondialdehyde, 8-hydroxy-2-deoxy guanosine (8-OH-dG), advanced oxidation protein products (AOPP), total antioxidant capacity (TAC), visfatin, reduced glutathione, and chaperonin 60 were evaluated using enzyme-linked immunosorbent assay. SNPs in manganese superoxide dismutase (MnSOD), copper/zinc superoxide dismutase (Cu/Zn SOD), glutathione peroxidase (GPX1 and GPX3), catalase (CAT), glutathione S-transferase (GSTP1) were evaluated using real-time polymerase-chain-reaction. The receiver-operating characteristics curve was used for predicting the accuracy of biomarkers using the area under the curve (AUC) and 95% confidence intervals (95% CI). Results: GSTP1, MnSOD, and eNOS (rs1799983) SNPs were observed to significantly influence the oxidative biomarker concentrations in the entire study population. SNPs in GSTP1, MnSOD, and eNOS (rs1799983) were significantly associated with differences in oxidative stress biomarkers. MnSOD (rs4880) significantly increased the risk of pulmonary complications in neonates with RDS. DNA damage product (8-OH-dG) concentrations before surfactant administration has the best predictive accuracy (AUC: 0.8; 95% CI: 0.7-1; P = .001) for pulmonary complications with a cut-off value of 5008.8 pg/mL. TAC concentrations are significantly greater on day 2 and day 3 amongst neonates receiving surfactant compared to the control group. AOPP in the umbilical cord blood was observed to significantly predict the severity of RDS (AUC: 0.8; 95% CI: 0.6-1; P = .01) with an optimal cut-off value of 88.78 µmol/L. Conclusion: We observed that SNPs in eNOS and MnSOD significantly influence the production of oxidative stress biomarkers in preterm neonates. Baseline 8-OH-dG concentrations best predict the risk of pulmonary complications and AOPP concentrations in the umbilical cord blood predict the risk of RDS severity.
Combination of Baseline and Variation of Prognostic Nutritional Index Enhances the Survival Predictive Value of Patients With Advanced Non-Small Cell Lung Cancer Treated With Programmed Cell Death Protein 1 Inhibitor
Authors: Fang Qiyu , Yu Jia , Luo Jie , Deng Qinfang , Chen Bin , He Yayi , Zhang Jie , Zhou Caicun 
Published: November 2022

Background: Low baseline prognostic nutritional index (PNI) scores are associated with poor survival for various malignancies; however, they vary based on the cohort and time resulting in inaccurate results. We determined the predictive value of the PNI score variations in addition to the baseline PNI scores for patients with advanced non-small cell lung cancer (NSCLC) who received programmed cell death protein 1 (PD-1) inhibitor. Methods: We retrospectively analysed 115 patients with advanced NSCLC who received PD-1 inhibitor. The median follow-up period was 28 months. Patients were clustered into four groups based on the combined PNI scores (combination of baseline and variation of PNI scores): ΔPNI-L-L, ΔPNI-L-H, ΔPNI-H-L, and ΔPNI-H-H subgroups. For instance, if PNI scores of patients with high baseline PNI score increased from baseline to 6 weeks after treatment, they were included in the ΔPNI-H-H subgroup. Cox regression models were used to identify the factors associated with survival. Results: The baseline PNI score was only related to the overall survival (OS) ( P = .026), and not to the overall response rate (ORR) ( P = .299) and progression-free survival (PFS) ( P = .207). The ORR was associated with the combined PNI scores ( P = .017). A multivariable Cox regression analysis confirmed that the combined PNI scores were independent factors for PFS (ΔPNI-L-H, 12 months, hazard ratio [HR] = 0.449, P = .009; ΔPNI-H-L, 14 months, HR = 0.500, P = .019; and ΔPNI-H-H, 17 months, HR = 0.390, P = .012; vs ΔPNI-L-L, 8 months) and OS (ΔPNI-L-H, 27 months, HR = 0.403, P = .019; ΔPNI-H-L, 28 months, HR = 0.369, P = .010; and ΔPNI-H-H, not reached, HR = 0.087, P = .002; vs ΔPNI-L-L, 15 months). Conclusions: Patients with high baseline PNI and increased PNI score had the better survival outcome. On dynamic monitoring and comprehensive assessment, the combined PNI scores significantly enhanced the survival predictive ability of patients with NSCLC treated with PD-1 inhibitor.
Real-World Data of Trifluridine/Tipiracil for Patients With Advanced Gastric Cancer: A Multi-Institutional Retrospective Study
Authors: Matsumoto Toshihiko , Yamamura Shogo , Ikoma Tatsuki , Kurioka Yusuke , Doi Keitaro , Yasuda Tomoyo , Boku Shogen , Kawai Takashi , Shibata Nobuhiro , Nagai Hiroki , Tsuduki Takao , Shimada Takanobu , Matsumoto Yusuke , Tsumura Takehiko , Takatani Masahiro , Yasui Hisateru , Satake Hironaga 
Published: November 2022

Background: A trial with trifluridine/tipiracil (FTD/TPI) versus placebo in patients with heavily pretreated metastatic gastric cancer showed that FTD/TPI is effective with manageable toxicity in these patients. However, real-world data on the effects of FTD/TPI in patients with advanced gastric cancer (AGC) are limited. Methods: We retrospectively collected and analyzed the clinicopathological data of patients with AGC who received FTD/TPI monotherapy at our institutions (Kobe City Medical Center General Hospital, Osaka Red Cross Hospital, Himeji Red Cross Hospital, and Kansai Medical University Hospital) between September 2019 and July 2021. Tumor responses were evaluated based on the Response Evaluation Criteria in Solid Tumors, version 1.1. Overall survival (OS) and progression-free survival were estimated using the Kaplan-Meier method. Results: A total of 53 patients were included in the study. The median age was 70 (range, 37-85) years; 39 patients (74%) were men; the numbers of patients with Eastern Cooperative Oncology Group performance status scores of 0, 1, and 2 were 10 (19%), 39 (74%), and 4 (8%), respectively; and 27 patients (51%) had diffuse-type histology. A total of 29 patients (56%) had ascites. Prior nivolumab therapy was administered to 49 patients (92%). The response rate and disease control rate (DCR) were 2% and 35%, respectively. The median progression-free survival was 2.4 months, and OS was 5.8 months. Patients with ascites exhibited significantly shorter OS (8.6 vs 4.7 months, P = .0291) than those without ascites, and DCR (54% vs 18%, P = .0055) was significantly worse in patients with ascites. There was no significant difference in the frequency of adverse events of grade 3 or higher between patients with and without ascites. Conclusion: In a real-world setting, FTD/TPI has similar effectiveness as late-line chemotherapy for patients with AGC, including those who previously had received nivolumab.