bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood-Based Biomarkers for Alzheimer’s Disease in Older Adults with Posttraumatic Stress Disorder
Authors: Cimino Nicolas , Kang Min Suk , Honig Lawrence S. , Rutherford Bret R. 
Published: January 2022

Background: Posttraumatic stress disorder (PTSD) is associated with cognitive decline and risk for dementia, but the neuropathology involved is unclear. Objective: The aim of this study was to determine whether PTSD is associated with increased levels of Alzheimer’s disease (AD) blood-based biomarkers. Methods: Individuals aged 50 years and older with PTSD were compared to trauma-exposed healthy controls (TEHCs) at baseline on serum measures of amyloid- β (A β) 42 and 40 levels, the A β42/A β40 ratio, and total tau. Serum was analyzed using ultrasensitive Simoa Human Neurology 3-Plex A assay (N3PA). Linear regressions modeling each AD biomarker as a function of group were used to investigate between-group differences, controlling for age, sex, and educational attainment (years). Results: TEHC participants ( N = 26) were 53.8% male with mean age 66.8±10.7, whereas PTSD participants ( N = 44) were 47.7% male and aged 62.5±9.1 years. No between-group differences were noted on demographic characteristics or cognitive performance measured with the NIH Toolbox Cognition Battery. There were no significant between-group differences in serum A β40 (TEHC 105.8±51.6 versus PTSD 93.2±56.1, p = 0.46), A β42 (TEHC 8.1±4.6 versus PTSD 7.8±4.6, p = 0.63), A β42/A β40 (TEHC 0.08±0.03 versus PTSD 0.09±0.03, p = 0.27), or total tau (TEHC 0.5±0.3 versus PTSD 0.5±0.4, p = 0.77). Likewise, there were no significant interaction effects of amyloid or tau serum concentrations and PTSD group status on cognitive functioning. Conclusion: Findings from cognitive assessments and serum analyses do not support PTSD-induced neurodegeneration of the Alzheimer’s type as a pathway linking PTSD to increased incidence of dementia in older adults.
Head-to-Head Comparison between High-Resolution Microultrasound Imaging and Multiparametric MRI in Detecting and Local Staging of Bladder Cancer: The BUS-MISS Protocol
Authors: Diana Pietro , Lughezzani Giovanni , Saita Alberto , Uleri Alessandro , Frego Nicola , Contieri Roberto , Buffi Nicolomaria , Balzarini Luca , D’Orazio Federico , Piergiuseppe Colombo , Elefante Maria Grazia , Lazzeri Massimo , Guazzoni Giorgio , Casale Paolo , Hurle Rodolfo 
Published: January 2022

BACKGROUND: MRI has been proposed as a new staging tool for bladder cancer (BC), but use is limited by its high costs and low availability. 29-MHz high-resolution micro-ultrasound (mUS) technology has been suggested as an alternative to detect BC and distinguish between muscle-invasive and non-muscle invasive BC. OBJECTIVE: The aim was to compare the diagnostic accuracy of mUS vs. magnetic resonance imaging (MRI) in differentiating NMIBC and MIBC at definitive pathological examination. METHODS: This is a prospective study of patients with a primary diagnosis of BC with either positive urine cytology (UC) or negative UC and a tumor size > 25 mm from a tertiary care high volume center. mUS, with the ExactVu system with an EV29L 29 MHz side-fire transducer, and a 3-Tesla MRI were performed before transurethral resection of bladder tumor (TURBT) in every patient before undergoing TURBT. We compared the imaging results with pathological reports. RESULTS: The analyzed population consisted of 58 individuals. The reported mUS and MRI sensitivity, specificity, positive, and negative predictive values were 85.0%, 76.3%, 65.4%, and 90.6%, versus 85.0%, 50.0%, 47.2%, and 86.4%, respectively. In accuracy analysis, the AUC for mUS and MRI were respectively 0.807 and 0.675. CONCLUSIONS: In our population mUS seems to have a better performance in distinguishing NMIBC from MIBC. The main limitation of mUS is the probe shape that makes its use problematic in cases with a large prostate and inadequate rectal preparation. Further studies with a larger population are ongoing to compare and validate these techniques in this setting.
Evolution of Prodromal Multiple System Atrophy from REM Sleep Behavior Disorder: A Descriptive Study
Authors: Postuma Ronald B. , Pelletier Amelie , Gagnon Jean-Francois , Montplaisir Jaccques 
Published: January 2022

Background: Prodromal multiple system atrophy (MSA) has been characterized mainly by retrospective chart reviews. Direct observation and tracking of prodromal markers in MSA have been very limited Objective: To report the baseline characteristics and evolution of prodromal markers of MSA as they were prospectively measured in patients with idiopathic/isolated REM sleep behavior disorder (iRBD) Methods: Patients with iRBD were evaluated as part of a comprehensive protocol repeated annually. The protocol included assessment of motor, sleep, psychiatric, and autonomic symptoms supplemented by motor examination, quantitative motor testing, neuropsychological examination, orthostatic blood pressure measurement, and tests of olfaction and color vision. Patients who eventually developed MSA were described and compared with those who phenoconverted to Lewy body disease (Parkinson’s disease and dementia with Lewy bodies). Results: Of 67 phenocoverters, 4 developed MSA-P and 63 developed Lewy body disease. An additional 2 MSA-C patients were seen at baseline, already with cerebellar signs. Compared to those with Lewy body disease, those with MSA-P were younger, had less severe loss of tonic REM sleep atonia, more insomnia symptoms, and better olfaction. Clinically-evident autonomic dysfunction was not invariable in prodromal stages, often developing proximate to or after motor phenoconversion. Of the autonomic symptoms, genitourinary dysfunction was the first to develop in all cases. Olfaction and cognition remained normal throughout the prodromal and clinical disease course, in clear contrast to patients with Lewy body disease. Conclusion: Prodromal MSA progresses rapidly, often without substantial autonomic dysfunction, and with preserved olfaction and cognition throughout its prodromal course.
Pengaruh Service Quality dan Product Quality Terhadap Loyalitas dan Kepuasan Konsumen Pada Agrowisata Pulesari, Sleman, DIY
Authors: Jati Pandu Kusuma , Chasanah Uswatun , Hidayat Anas 
Published: January 2022

The goal of this research was to discover the impact of product quality and service quality on loyalty and customer satisfaction. Product quality and service quality are the independent variabels which influence user loyalty in an integrated manner. The researchers employed an intervening variable which is customer satisfaction. This study used a questionnaire survey for carrying out the data of research. Simple random sampling was used as a technique for determining of 275 respondents as the number of samples in this research. The researchers employed Path Analysis as the analysis method in this study. The SPSS Version 23.00 was used as tool for testing the data.
Based on Kolmogorov-Smirnov test, all data were normally distributed as the results of the normality test conducted. Meanwhile, the items in all variables are valid based on the results of Pearson Correlation as the validity test and the researchers employed the Cronbach's Alfa test for testing the reliability whose values are seen. There are three tests for testing the hypothesis such as t-test, F test, and R Square in this study.
The results show that all are accepted. Customer loyalty and customer satisfaction are affected by product quality and service quality. And, the effect of service quality and product quality on consumer loyalty is also proven mediated by customer satisfaction
P Penerapan Konseling Realita bagi Siswa Underachiever di SMK Muhammadiyah 1 Prambanan
Authors: Marsudi Muhammad Sholeh 
Published: January 2022

Tulisan ini bertujuan untuk membahas tentang penerapan konseling realita bagi siswa underachiver, yang mencakup konsep tentang konseling realita, konsep underachiever dan upaya penerapan konseling realita bagi siswa underachiever. Metode yang digunakan adalah field research atau penelitian lapangan dimana peneliti melakukan studi observasi, yang dilakukan tidak hanya melalui kajian teori tetapi juga melakukan penelitian di lokasi. Hasil penelitian menunjukkan bahwa penerapan konseling realita bagi siswa underachiever melalui; Pertama, be friend dengan menunjukkan keterlibatan pada peserta didik. Kedua, dengan fokus pada perilaku saat ini. Ketiga, Doing dengan menanyakan apa yang akan dilakukan peseta didik. Keempat, dengan mengevaluasi atau menilai diri sendiri. Kelima, merencanakan uapaya yang penuh tanggungjawab. Keenam, menentukan komitmen. Ketujuh, Tidak menerima alasan atau permintaan maaf. Dan Kedelapan, Tindak lanjut.
Molecular epidemiology and antimicrobial susceptibility of carbapenemase-producing extraintestinal Escherichia coli in a tertiary care hospital of Dhaka, Bangladesh
Authors: Afroz Fatima , Anwar Shaheda , Akhtar Rokshana , Saleh Ahmed Abu 
Published: January 2022

The emergence of carbapenemase producing Escherichia coli, the first hospital and community-acquired opportunistic pathogen now become a great public health concern. A total of 23 clinical isolates of carbapenemase producing E. coli from extraintestinal infections in a tertiary care hospital of Bangladesh were studied. Highest percentage of carbapenemase producing E. coli isolates were from urine samples (52.2%) followed by 21.7% from each of wound swab and pus and 4.1 % from blood samples. Among the E. coli isolates 69.6% were from indoor patients and 30.4% were from outdoor patients. All the isolates (100%) were positive for NDM of which 13% were NDM and OXA-48 co-producers by conventional PCR. Carbapenemase producing E. coli isolates were resistant to most of the antibiotic tested except for nitrofurantoin, colistin, polymyxin B and tigecycline with a sensitivity of 66.7%, 82.6%, 95.7% and 100% respectively.
Bangladesh J Med Microbiol 2020; 14 (1): 3-6
COVID-19 Severity and ABO Blood Types; Association and Molecular Mechanisms A short Review
Authors: Khan Nazia Hasan , Mannan Nusrat , Zaman Mohammad Saroare , Akram Arifa 
Published: January 2022

Genetically inherited characteristics of blood group phenotypes, whose association with certain infectious diseases have been debated for long. Growing evidence suggests that ABO blood group may play a role in the immunopathogenesis of SARS-CoV-2 infection. The level of evidence supporting an association between ABO type and COVID-19 ranges from small observational studies, to genome-wide-association-analyses and country-level meta-regression analyses. We tried to find out the molecular relations of SARS-CoV-2 infection and ABO blood groups. We discussed inherited associations and possible molecular mechanisms that drive the relationship between blood type and COVID-19. Similar and non-similar comments and demonstrations from several studies are simply notified here.
Bangladesh J Med Microbiol 2020; 14 (2): 30-35
Focal Cortical Dysplasia as Cause of Refractory Epilepsy- A Case Report
Authors: Saha Sujan , Al Muzahid Md Abdullah , Chowdhury Ashish , Hasan Mehedi , Roy Uttam , Kabir Md Suman , Islam Md Rafiqul 
Published: January 2022

Focal Cortical Dysplasia (FCD) is one of the most common causes of refractory epilepsy in children as well as adult where malformed cortical development occurs resulting from abnormal neuronal migration due to both genetic and acquired factors. Herein, a 22-year-old male presented with recurrent secondary generalized tonic seizure with aura since childhood. Despite adequate anti-epileptic medications with good compliance the seizure was uncontrolled. As a cause, Type II FCD was diagnosed by specific neuroimaging findings supported by EEG abnormalities. Till now in refractory epilepsy FCD is rarely diagnosed but there remains a good hope of cure by surgical intervention.
Bangladesh Journal of Neuroscience 2019; Vol. 35 (1): 46-50
Sustentabilidade em tempos de pandemia: uma análise hoje para um novo fazer amanhã
Authors: Lima Jorcelyo Alencar , Alencar Elisangela de Andrade Borges , Fonseca Graicy Cavalcante 
Published: January 2022

Sustentabilidade em tempos de pandemia: uma análise hoje para um novo fazer amanhã veicula uma análise epistemológica e conceitual sobre Sustentabilidade, contemplando os seus diversos ambientes de atuação, desde às ideias iniciais, até esse momento ímpar na história da humanidade: a pandemia causada pelo Covid-19. As questões se inserem na ressignificação de Sustentabilidade em contexto de pandemia, onde alguns aspectos ambientais foram beneficiados pelo isolamento social, como o ar, a água, os rios e oceanos; mas por outro lado, uma das principais consequências foi a questão do lixo que, não sendo mais produzido na rua, nas escolas e universidades, nos restaurantes, se acumularam nas casas, formando um grande problema ambiental e social. Para as empresas, esse momento de pandemia se estabelece como um momento oportuno para agregar novos valores e impactar com serviços e produtos, desde que usem estratégias eficazes para a contenção dos dejetos produzidos. Por fim, o universo de ações urgentes e necessárias para que se possa ter e garantir vida sustentável, no seu conceito mais lato, contemplando todas as dimensões da vida humana parecem ter nascidas ou adquirido consistência com a tão depredadora crise sanitária do Covid-19, pois toda a humanidade, de forma consciente ou inconsciente, estão mudando hábitos e comportamentos, buscando estratégias para uma maior qualidade de vida e promovendo, dessa forma, a sustentabilidade do Planeta para esta para as gerações futuras.
Analisis Kerusakan Jaringan Insang Ikan Mas (Cyprinus carpio L.) Setelah Terpapar Pestisida Klorpirifos
Authors: Amaliyah Viki , Santoso Hari , Syauqi Ahmad 
Published: January 2022

The use of chlorpyrifos pesticide as an agricultural pest exterminator if excessive and carried out continuously can have a large negative impact on biotic and abiotic life. Fish as one of the environmental bioindicators of pesticide contamination, because the gill organs will receive chemical effects in taking oxygen in pesticide-contaminated water ponds. The purpose of this study was to analyze the level of damage to the gill tissue of carp (Cyprinus carpio) exposed to the pesticide chlorpyrifos at various concentration levels. This research was carried out at the Punten Freshwater Cultivation Installation, Batu City, East Java. Using the experimental method with concentrations of acute toxicity treatment (LC50) namely K1 0.25 ppm, K2 0.30 ppm, K3 0.35 ppm, K4 0.40 ppm, K5 0.45 ppm. The research data were analyzed descriptively in the form of tables and graphs. The results of the preliminary acute toxicity test (LC50) were in the range of K1 0.25 ppm and K2 0.30 ppm. Furthermore, Alizarin Red staining was performed to give color to the gills. The results of acute toxicity test (LC50) Total percentage of damage at a concentration of 0.25 ppm 22.28% and a concentration of 0.30 ppm 77.54%. Damage to gill tissue exposed to the pesticide chlorpyrifos showed an acute level occurred at a concentration of 0.30ppm, where the higher the concentration, the higher the gill damage.Keywords: Chorphyrifos Pesticide, Cyprinus carpio, Precentage of DamageABSTRAKPenggunaan pestisida klorpirifos sebagai pembasmi hama pertanian bila berlebihan dan dilakukan secara terus menerus dapat menimbulkan dampak negatif yang besar bagi kehidupan biotik dan abiotik. Ikan sebagai salah satu bioindikator lingkungan tercemar pestisida, karena organ insang akan menerima efek kimiawi dalam mengambil oksigen pada kolam perairan yang tercemar pestisida. Tujuan penelitian ini adalah untuk menganalisis tingkat kerusakan jaringan insang ikan mas (Cyprinus carpio) yang terpapar pestisida klorpirifos pada berbagai level konsentrasi. Penelitian ini dilaksanakan di Instalasi Budidaya Air Tawar Punten, Kota Batu, Jawa Timur. Menggunakan metode eksperimen dengankonsentrasi perlakuan toksisitas akut (LC50) yaitu K1 0,25 ppm, K2 0,30 ppm, K3 0,35 ppm, K4 0,40 ppm, K5 0,45 ppm. Data penelitian dianalisis secara deskriptif dalam bentuk Tabel dan Grafik. Hasil uji pendahuluan toksisitas akut (LC50) berada pada kisaran K1 0,25 ppm dan K2 0,30 ppm. Selanjutnya dilakukan pewarnaan Alizarin Red untuk memberi warna pada insang. Hasil uji toksisitas akut (LC50) Total presentase kerusakan pada konsentrasi 0,25 ppm 22,28% dan konsentrasi 0,30 ppm 77,54%. Kerusakan jaringan insang yang terpapar pestisida klorpirifos memperlihatkan tingkat akut terjadi pada perlakuan konsentrasi 0,30ppm, dimana semakin tinggi konsentrasi akan semakin tinggi kerusakan insang.Kata kunci : Pestisida Klorpirifos, Cyprinus carpio, Kerusakan Insang.
Hubungan Permainan Outbound dengan Perkembangan Sosial Anak di taman Kanak-kanak Kecamatan Padangsidimpuan Utara
Authors: Latifah Rahmy , Marlina Serli 
Published: January 2022

Penelitian ini bertujuan untuk mengetahui hubungan permainan outbound dengan perkembangan sosial anak di Taman Kanak-kanak Kecamatan Padangsidimpuan Utara. Metode Penelitian yang digunakan adalah kuantitatif yang berbentuk korelasi dengan Teknik pengambilan sampel yaitu dengan cara gugus (cluster sampling). Hasil Penelitian terlihat bahwa terdapat hubungan antara permainan outbound dengan perkembangan sosial anak di Taman Kanak-kanak Kecamatan Padangsidimpuan utara sebesar 85%. Dapat disimpulkan bahwa permainan outbound memiliki hubungan terhadap perkembangan sosial anak.
Aortic Coarctation Associated With Hypertrophic Cardiomyopathy in a Woman With Hypertension and Syncope: A Case Report With 8-Year Follow-Up
Authors: Yang Hong , Wang Hong , Li Zongzhe , Yan Jiangtao , Song Yu-E , Zeng Hesong , He Xingwei , Li Rui , Wang Dao Wen 
Published: January 2022

BackgroundCoarctation of the aorta (CoA) is a common congenital cardiovascular malformation with aortic narrowing in the region of the ligamentum arteriosum. Hypertrophic cardiomyopathy (HCM) is a primary cardiomyopathy that is characterized by left ventricular wall thickening and likely left ventricular outflow tract (LVOT) obstruction. They are two irrelevant diseases, and their coexistence has not been reported before. Here, we described a young female patient who concurrently has CoA and HCM.Case PresentationThe patient has had hypertension since 18-years old and complained of chest discomfort on effort and fatigue thereafter. Initially, she was diagnosed as having hypertrophic cardiomyopathy and primary hypertension. The presence of CoA was not found until she was 35 years old when she had an onset of paroxysmal supraventricular tachycardia (PSVT) and presented with syncope. Failure of the ablation procedure via the femoral artery revealed the possibility of CoA and PDA that was confirmed by aortic CTA and angiography. CoA was then treated successfully with a covered stent, and the symptoms of the patient improved remarkably. Additionally, the patient had typical imaging features of HCM, and two novel HCM-causing heterozygous mutations were identified by genetic testing, DSP-encoding desmoplakin, and MYBPC3-encoding myosin-binding protein C. The HCM was suspected to be contributing to the clinical presentations of the patient and challenged the timely diagnosis of CoA. The 8-year follow-up on aortic CTA and angiography revealed no stent graft-related complications. Moreover, no changes in HCM-related imaging features were found in the follow-up echocardiography 8 years after the correction of aortic coarctation, which strengthened the diagnosis of HCM.ConclusionHere, we reported the diagnostic challenges, management, and 8-yeasr follow-up findings in a rare case of CoA combined with HCM. The case highlighted the importance for physicians to exclude CoA in young hypertensive patients, and proved the efficacy of stent repair in treating CoA in older patients.
Cumulative Evidence for the Association of Thrombosis and the Prognosis of COVID-19: Systematic Review and Meta-Analysis
Authors: Xiao Dongqiong , Tang Fajuan , Chen Lin , Gao Hu , Li Xihong 
Published: January 2022

BackgroundAlthough thrombosis events have been reported in patients with coronavirus disease 2019 (COVID-19), the association between thrombosis and COVID-19-related critical status or risk of mortality in COVID-19 has been inconsistent.ObjectiveWe conducted a meta-analysis of reports assessing the association between thrombosis and the prognosis of COVID-19.MethodsThe EMBASE, Ovid-MEDLINE, and Web of Science databases were searched up to December 9, 2021, and additional studies were retrieved via manual searching. Studies were included if they reported the risk of COVID-19-related critical status or COVID-19-related mortality in relation to thrombosis. The related data were extracted by two authors independently, and a random effects model was conducted to pool the odds ratios (ORs). In addition, stratified analyses were conducted to evaluate the association.ResultsAmong 6,686 initially identified studies, we included 25 studies published in 2020 and 2021, with a total of 332,915 patients according to predefined inclusion criteria. The associations between thrombosis and COVID-19-related mortality and COVID-19-related critical status were significant, with ORs of 2.61 (95% CI, 1.91–3.55, p &lt; 0.05) and 2.9 (95% CI, 1.6–5.24, p &lt; 0.05), respectively. The results were statistically significant and consistent in stratified analyses.ConclusionsThrombosis is associated with an increased risk of mortality and critical status induced by COVID-19. Further prospective studies with large sample sizes are required to establish whether these associations are causal by considering more confounders and to clarify their mechanisms.Observational studies cannot prove causality. However, autopsy studies show thrombosis events preceding COVID-19-related deaths. The results of this meta-analysis reported that thrombosis was associated with a 161% increased risk of mortality from COVID-19 and a 190% increased risk of COVID-19-related critical status. The type of thrombosis included in the original studies also seemed to be related to the results.
Evolution of Disease Modifying Therapy Benefits and Risks: An Argument for De-escalation as a Treatment Paradigm for Patients With Multiple Sclerosis
Authors: Vollmer Brandi L. , Wolf Andrew B. , Sillau Stefan , Corboy John R. , Alvarez Enrique 
Published: January 2022

BackgroundStrategies for sequencing disease modifying therapies (DMTs) in multiple sclerosis (MS) patients include escalation, high efficacy early, induction, and de-escalation.ObjectiveTo provide a perspective on de-escalation, which aims to match the ratio of DMT benefit/risk in aging patients.MethodsWe reanalyzed data from a retrospective, real-world cohort of MS patients to model disease activity for oral (dimethyl fumarate and fingolimod) and higher efficacy infusible (natalizumab and rituximab) DMTs by age. For patients with relapsing MS, we conducted a controlled, stratified analysis examining odds of disease activity for oral vs. infusible DMTs in patients &lt;45 or ≥45 years. We reviewed the literature to identify DMT risks and predictors of safe discontinuation.ResultsYounger patients had lower probability of disease activity on infusible vs. oral DMTs. There was no statistical difference after age 54.2 years. When dichotomized, patients &lt;45 years on oral DMTs had greater odds of disease activity compared to patients on infusible DMTs, while among those ≥45 years, there was no difference. Literature review noted that adverse events increase with aging, notably infections in patients with higher disability and longer DMT duration. Additionally, we identified factors predictive of disease reactivation including age, clinical stability, and MRI activity.ConclusionIn a real-world cohort of relapsing MS patients, high efficacy DMTs had less benefit with aging but were associated with increased risks. This cohort helps overcome some limitations of trials where older patients were excluded. To better balance benefits/risks, we propose a DMT de-escalation approach for aging MS patients.