bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Diagnostic Value of Pan-Trk Expression to Detect Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusion in CNS Tumours: A Study Using Next-Generation Sequencing Platform
Authors: Mohamed Fawaz , Kurdi Maher , Baeesa Saleh , Sabbagh Abdulrahman Jafar , Hakamy Sahar , Maghrabi Yazid , Alshedokhi Mohammed , Dallol Ashraf , Halawa Taher F. , Najjar Ahmed A. , Fdl-Elmula Imad 
Published: February 2022

Background: Neurotrophic tyrosine receptor kinase (NTRK) fusion has been detected in rare types of CNS tumours, which can promote tumorigenesis. The efficacy of Trk inhibitor became a significant therapeutic interest. Our aim was to investigate whether Pan-Trk immunohistochemistry (IHC) is a reliable and efficient marker for detecting NTRK-fusion in different brain tumours.Methods: This study included 23 patients diagnosed with different types of CNS tumours. Testing for Pan-Trk IHC with monoclonal Ab (EPR17341) has been performed on all FFPE tissues. Parallelly, NTRK-rearrangements were tested using both DNA and RNA-based next-generation sequencing (NGS) assay using TruSight Onco500 platform.Results: The cohort included eight pilocytic astrocytomas, one oligodendroglioma, six IDHwildtype glioblastomas, four IDHmutant grade four astrocytomas, and one sample of each (astroblastoma, central neurocytoma, medulloblastoma, and liponeurocytoma). The mean age was 35 years; seven cases were in the paediatric age group, and 16 were adult. Pan-Trk expression was detected in 11 (47.8%) tumours, and 12 (52.1%) tumours showed no Pan-Trk expression. Nine Cases (82%) with different Pan-Trk expressions did not reveal NTRK-rearrangement. The other two positively expressed cases (liponeurocytoma and glioblastoma) were found to have NTRK2-fusions (SLC O 5A1-NTRK2, AGBL4-NTRK2, BEND5-NTRK2). All the 12 cases (100%) with no Pan-Trk expression have shown no NTRK-fusions. There was no statistically significant association between Pan-Trk expression and NTRK-fusion (p = 0.217). The detection of NTRK- fusions using NGS had high specificity over NTRK-fusion detection by using Pan-Trk IHC.Conclusion: Pan-Trk IHC is not a suitable tissue-efficient biomarker to screen for NTRK-fusions in CNS tumours, however RNA-based NGS sequencing should be used as an alternative method.
Pressure-controlled ultrasound probe for reliable imaging in breast cancer diagnosis
Authors: Matsumoto Yukina , Katsumura Ayu , Miki Norihisa 
Published: February 2022

Abstract
Breast cancer is the most common cancer among women worldwide, with over 2 million new cases diagnosed each year. Early detection can be achieved by screening examinations such as mammography and ultrasonography. The latter has demonstrated advantages such as safety and sensitivity to dense breasts, but is often performed as a follow-up test after abnormal findings at mammography or on palpation. Indeed, the technique shows limitations of operator-dependence and non-reproducibility, since the quality of imaging is highly dependent on the skill of the technologist performing the examination. We therefore designed a diagnosis-assisting device comprising piezoresistive sensors of microscale thickness that can be attached to the ultrasound transducer. The operator is informed when excessive pressure is detected, allowing correction of the transducer position. Finally, we fabricated a breast phantom including tumors from agar and collagen to assess the effectiveness of the device.
Terahertz parametric oscillator with a rhombic ring-cavity
Authors: Gao Feilong , Xie Yiyan , Wang Yiran , Su Xiancui , Li Guoru , Kumar Santosh , Zhang Bingyuan 
Published: February 2022

Abstract
Terahertz parametric oscillator (TPO) with a rhombic ring-cavity is demonstrated. The oscillating cavity is composed of three mirrors and the terahertz emitting-surface. Terahertz frequency can be tuned from 0.9 THz to 2.9 THz just by shifting the position of a cavity mirror. Under a certain round-trip optical length of the Stokes beam, the pump beam size can be larger in the rhombic ring-cavity TPO than that in the conventional resonant-cavity TPO. The maximum terahertz pulse energy in the rhombic ring-cavity TPO is 3.21 μJ, which is about 3 times higher than that in the conventional resonant-cavity TPO.
In situ manipulation of perpendicular magnetic anisotropy in half-metallic NiCo2O4 thin film by proton insertion
Authors: Wada T. , Namiki W. , Tsuchiya T. , Kan D. , Shimakawa Y. , Higuchi T. , Terabe K. 
Published: February 2022

Abstract
Herein we report the manipulation of perpendicular magnetic anisotropy (PMA), a very important technique for spintronics devices, which is achieved in an all-solid-state redox (reduction/oxidation) device. The device consisted of NiCo2O4 (NCO) thin film with a c-axis orientation and a proton-conducting polymer (Nafion). The PMA of NCO can be manipulated in situ with low voltage (V ≤ 0.7 V) due to the utilization of a proton-conducting solid electrolyte. The magnetic anisotropy variation was quantitatively evaluated by an anomalous Hall measurement. The magnetic anisotropy field of the NCO thin film was successfully manipulated in the range of 5%, although the rotation of the easy axis of magnetization was not observed. This modulation is attributed to the strain and electronic configuration variation by proton insertion. This manipulation method for PMA with the solid electrolyte enables a variety of reservoir states and contributes to lower power consumption and high-precision machine learning.
Comparative study of piston mode designs for temperature-compensated surface acoustic wave resonators using SiO2/LiNbO3 structure
Authors: Li Yawei , Gong Keyuan , Wong Yu-Po , Chen Pingjing , Wu Zhaohui , Liang Qi , Bao Jing-fu , Hashimoto Kenya 
Published: February 2022

Abstract
This paper compares three different piston mode designs for temperature-compensated surface acoustic wave (TC-SAW) resonators using SiO2/LiNbO3 structure. It was shown that in rough approximation, phase shift given by extra elements for the piston mode operation is determined by the total mass of extra elements and SiO2 which overlaid on piston region. The hammer head design without additional metal layers does not work properly due to the weaker impact of the extra elements when the SiO2 layer is thick. On the other hand, piston mode designs using metal dots or stripes are effective to suppress the transverse mode resonances even when the SiO2 layer is thick. Although larger metal thickness is preferable for the wideband operation, it also makes the split of main resonance. Thus, the optimal metal thickness can be found from this trade-off, and then the optimal metal width can be found to achieve good transverse mode suppression.
Pengaruh Keterampilan Guru Matematika Mengadakan Variasi Dalam Menggunakan Aplikasi Google Meet Dan Motivasi Mengajar Terhadap Kinerja Pada Masa Pandemi
Authors: Saraswati Yulia , Rosita Tita , Aziz Tian Abdul 
Published: February 2022

<p><em>Pada masa covid-19 Keterampilan guru mengajar menggunakan media daring menjadi factor kurangnya dalam pembelajaran. Kurangnya Keterampilan guru dipengaruhi oleh motivasi mengajar yang menurun saat pandemic. Akibatnya penurunan kinerja pada pembelajaran matematika inipun menurun. Pada penelitian ini dilakukan bertujuan untuk mengetahui pengaruh keterampilan guru mengadakan variasi dalam menggunakan aplikasi Google Meet dan motivasi mengajar terhadap kinerja guru pada pembelajan matematika kelas V di gugus II SD Kecamatan Jatiasih. Metode pada ini penelitian menggunakan metode survey dengan teknik pengumpulan data melalui angket Skala Likert. Metode pada ini penelitian menggunakan metode survei dengan teknik pengumpulan data melalui angket Skala Likert. Sampel yang digunakan Convenience Sampling</em><em> </em><em>dengan jumlah sampel 100 guru matematika SD. Teknik analisis data menggunakan regresi. Keterampilan guru mengadakan variasi dalam menggunakan aplikasi Google meet dan motivasi mengajar mempunyai pengaruh yang sigifikan terhadap kinerja guru dalam pembelajaran matematika kelas V di SD gugus II kecamatan Jatiasih, dengan besar pengaruh Keterampilan guru mengadakan variasi dalam menggunakan aplikasi Google meet dan motivasi adalah 63,95 %. Maka dapat disimpulkan bahwa adanya pengaruh keterampilan guru mengadakan variasi mengadakan variasi dalam menggunakan aplikasi Google Meet dan motivasi mengajar terhadap kinerja guru pada pembelajaran matematika kelas V di SD gugus II di kec. Jatiasih di masa pandemi.</em></p>
القيم الشعرية في شعر زمرك (دراسة فنية)
Authors: عثمان م. د. أفراح علي 
Published: February 2022

لقد طبع الله تعالى النفس الانسانية على حب الجمال، والتغني به أينما وجد فهي فطرة إنسانية عند البشر، فتطرب الأذن لسماع كل جميل كما ويعشق القلب كل جميل وانطلاقا من ذلك كان بحثنا بعنوان ((القيم الجمالية في شعر ابن زمرك)) دراسة فنية، وقد تطلب ذلك تقسيم البحث على مبحثين، تقدمهما تمهيدا مقسما على فقريين، كانت إحداهما في بيان مفهوم القيمة والجمال، أما الأخرى؛ فكانت إضاءة بسيطة لحياة ابن زمرك إذ لابد من معرفة سطور عن حياته قبل البدء بقراءة شعره، أما المبحث الأول؛ فكان في بيان القيم الجمالية في ديوانه مقسما على ثلاث نقاط الأولى في جمال الحبيبة، والثانية في جمال الممدوح أو نفس الممدوح، والثالثة في جمال الوطن، وجاء المبحث الثاني للدراسة الفنية مقسما على ثلاث نقاط أيضا، كانت الأولى في دراسة بعض أساليب شعره، ومنها الاستفهام، والنداء، والثانية في الصورة الشعرية، فعرضنا الصورة الاستعارية والتشبيهية في بعض اشعاره، وكانت الأخيرة في الدراسة الموسيقية الداخلية لشعره، مقسمة على التكرار، والجناس، والطباق، أعقب كل ذلك خاتمة تضمنت أهم النتائج، ثم قائمة بالمصادر والمراجع.
Pengaruh Modal Kerja Terhadap Rentabilitas Pada PT. Bukit Agung Sehati Palembang
Authors: Mulatsih Endang Sri 
Published: February 2022

Penelitian ini menguji Pengaruh Pengaruh Modal Kerja Terhadap Rentabilitas Pada PT. Bukit Agung Sehati Palembang. Tujuan dari penelitian ini adalah Untuk mengetahui modal kerja mempunyai pengaruh terhadap rentabilitas pada PT. Bukit Agung Sehati Palembang selama periode 2015-2019. Metode Penelitian dengan menggunakan Obyek Penelitian yang dilakukan di PT. Bukit Agung Sehati Palembang yang beralamat di Jalan Padat Karya Rt.4 No.18 Kelurahan Talang Buluh Kecamatan Talang Kelapa Kabupaten Banyuasin. Di mana Ruang lingkup penelitian adalah Modal Kerja terhadap kinerja keuangan di PT. Bukit Agung Sehati Palembang, laporan keuangan yaitu Neraca dan Rugi- laba. Dari hasil perhitungan maka dapat dibentuk persamaan regresi yaitu :
Y = 0,315+0,019X Hasil yang didapat dari analisis regresi sederhanan dengan mengunakan alat SPSS versi 22 menunjukkan bahwa ada pengaruh dari Modal Kerja Terhadap Rentabilitas Pada PT. Bukit Agung Sehati Palembang.
PENGARUH GAJI DAN INSENTIF KARYAWAN TERHADAP PRESTASI KERJA KARYAWAN PADA GEDUNG WANITA RAJAWALI PALEMBANG
Authors: Cahyani Eni 
Published: February 2022

Penelitian ini menguji Untuk mengetahui pengaruh gaji dan insentif terhadap prestasi kerja karyawan pada gedung wanita rajawali Palembang. Metode penelitian ini menggunakan
metode deskriptif adalah metode analisa yang tidak hanya mengambarkan tetapi juga menguraikan dan mengambil kesimpulan yang tidak terlalu jauh dari data yang diperoleh.
Hasil analisis dan pembahasan menunjukkan. ada pengaruh yang positif dan signifikan antara gaji dan insentif terhadap prestasi kerja karyawan. Dengan demikian hipotesisnya terbukti dan dari hasil persamaan regresi linier berganda dengan nilai koefisien 0,072 dan 0,111 menunjukkan bahwa Gaji dan Insentif berpengaruh positif dengan Prestasi Kerja Karyawan. Dimana semakin baik pelaksanaan Gaji dan Insentif Karyawan maka akan mempengaruhi prestasi kerja karyawan dan dapat maeningkatkan prestasi kerja karyawan.
Analisis Pengukuran Kinerja Keuangan Terhadap Rasio Rentabilitas Pada PT. Persada Bahari Kencana Palembang
Authors: Agussalim Agussalim 
Published: February 2022

Penelitian ini menguji Pengaruh Analisis Pengukuran Kinerja Keuangan Terhadap Rasio Rentabilitas Pada PT. Persada Bahari Kencana Palembang. Tujuan dari penelitian ini adalah Untuk mengetahui analisis pengukuran kinerja keuangan terhadap raasio rentabilitas pada PT. Persada Bahari Kencana Palembang dari tahun 2015 sampai 2019 dan Bagaimana kinerja keuangan perusahaan pada PT. Persada Bahari Kencana Palembang dari tahun 2015 sampai 2019 berdasarkan pengukuran rentabilitas.
Metode Penelitian dengan menggunakan Obyek Penelitian yang dilakukan di PT. Persada Bahari kencana yang beralamat di Jalan Residen Abdul Rozak Komplek PHDM VI No.01 Palembang. Dimana Ruang lingkup penelitian adalah Pengaruh pengaruh kinerja keuangan terhadap rasio rentabilitas pada PT. Persada Bahari kencana Palembang adalah laporan keuangan yang terdiri dari Laporan Laba Rugi dan Neraca Perusahaan tahun 2015 sampai dengan 2019..Dari hasil perhitungan maka dapat dibentuk persamaan regresi yaitu :Cash Ratio Dengan ROI Y = 1.6 + 1,25x, Cash Ratio Dengan ROE Y = 0,08+ 0,04x CashRatio Dengan NPM Y = 26,3 + 0,88x
PENGARUH GAYA KEPEMIMPINAN DAN MOTIVASI TERHADAP KINERJA KARYAWAN PADA PT.BANK BNI SYARIAH KC.MIKRO KM 12 PALEMBANG
Authors: Anita Yuli 
Published: February 2022

Penelitian Pengaruh Gaya Kepemimpinan dan Motivasi Terhadap Kinerja Karyawan Pada PT. Bank BNI Syariah KC. Mikro KM 12 Palembang bertujuan untuk dapat menambah perbendaharaan ilmu bagi civitas akademik pendidikan khususnya tentang pengaruh gaya kepemimpinan. Menambah pengetahuan tentang pengaruh gaya kepemimpinan dan motivasi kerja terhadap kinerja karyawan di PT. PT. Bank BNI Syariah KC. Mikro KM. 12 Palembang dan untuk memperluas pengetahuan di dunia kerja khususnya di lembaga keuangan. Memberikan saran dan masukan bagi perusahaan sebagai tambahan informasi dan bahan pembanding.
Dalam penyusunan proposal skripsi akhir ini, penulis menggunakan tehnik analisis kualitatif, yaitu tehnik analisis yang di pakai guna menganalisis Pengaruh kepemimpinan dan motivaasi terhadap semangat kerja karyawan pada (perbandingan praktek lapangan dengan teori yang di dapat penulis dibangku kuliah).
Hasil yang didapat dari analisis pengujian hipotesis 1 ( dimana variabel penddikan berpengaruh positif dan signifikan terhadap kinerja karyawan PT.Pertamina Patra Niaga Palembang ), ternyata hasil pengujian mendukung hipotesis sehingga hipotesis diterima. Dimana variabel pendidikan secara parsial berpengaruhsignifikan terhadap kinerja karyawan. pengujian hipotesis 2 ( dimana variabel latihan berpengaruh positif dan signifikan terhadap kinerja karyawan PT. BNI Syariah cabang KC.Mikro Km 12 Palembang ternyata hasil pengujian mendukung hipotesis sehingga hipotesis diterima. Dimana variabel motivasi secara parsial berpengaruh signifikan terhadap kinerja karyawan. Serta variabel pendidikan dan latihan secara simultan berpengaruh signifikan terhadap kinerja karyawan.
PENGARUH PENGGUNAAN MODAL KERJA TERHADAP RASIO PROFITABILITAS PADA PT.PEGADAIAN (PERSERO) KANTOR WILAYAH III PALEMBANG
Authors: Hamdan Hamdan 
Published: February 2022

Penelitian ini bertujuan untuk. “Mengetahui penggunaan modal kerja apakah mempunyai pengaruh terhadap rasio profitabilitas Pada PT. Pegadaian (Persero) kantor Wilayah III Palembang selama periode 2016-2020” Metode yang digunakan dalam penelitian ini adalah deskriptif analitis dengan pendekatan studi kasus. Teknik pengumpulan data dilakukan melalui data primer yaitu data yang diperoleh langsung dari sumber data dimana penelitian ini dilaksanakan di PT.Pegadaian (Perser) Kantor Wilayah III Palembang dan data sekunder yaitu data yang diperoleh dari literatur dan buku-buku yang ada hubungannya dengan masalah yang akan diteliti. Alat analisis yang digunakan adalah uji regresi sederhana dengan skala pengukuran rasio.
Pada hasil Analisa Ratio Profitabilitasn Lemahnya ratio profitabilitas terletak pada keuntungan atau kemampuan untuk menghasilkan laba bersih atau pada laba kotor mengalami ketidakstabilan, sehingga pada PT. Pegadaian (persero) kanwil III Palembang jauh dibawah standar industrial yang baik yaitu 30 % , Net Earning Power Ratio untuk mengukur kemampuan dari modal yang diinvestasikan dalam keseluruhan dari aktiva untuk menghasilkan keuntungan netto pada tahun 2013 adalah 1,63 % , dan pada tahun 2014 mencapai 5,69 % dan pada tahun 2015 adalah 4,97 % , dan pada tahun 2016 mencapai 5,74% dan pada tahun 2017 mencapai 5,63%. Net Earning Power Ratio pada kelima tahun ini dibawah standar rasio, ini berarti kemampuan untuk menghasilkan keuntungan netto buruk. Persamaan regresi dengan cash ratio terhadap ROI pada perusahaan PT.Pegadaian (Persero) Kanwil III Palembang adalah Y = 1,6 + 1,25x. Dari persamaan tersebut diperoleh hasil korelasi (r) sebesar 0,3 yang artinya hubungan antara cash ratio terhadap ROI mempunyai pengaruh positif. Hal ini menjelaskan bahwa setiap kenaikan cash ratio akan diikuti dengan kenaikan pada ROI, demikian pula sebaliknya setiap penurunan cash ratio akan diikuti dengan persamaan ROI
Local Tourist favored Tanah Lot as a place to visit after COVID-19 lockdown
Authors: Adnyawati Ida Ayu Agung 
Published: February 2022

Tabanan Regent Ni Putu Eka Wiryastuti reopened five tourist attractions in Tabanan district closed since 22 March 2020 due to the Covid-19 pandemic. Those Tourist attractions were Tanah Lot, Ulundanu Temple, Eka Karya Botanical Garden Bedugul, The Blooms Garden Baturiti, and Jatiluwih, Penebel. She explained the decision was urgently needed to resurrect economic activity in Tabanan district in the new normal phase.1 Since the reopening day, domestic tourists flooded Tanah Lot, Tabanan. The number of visits had skyrocketed, starting from 20 July to 22 August 2020. As one of Bali's leading preferable tourist destinations, Tanah lot offers majestic landscapes and historical value that should not be missed. Established in the 16th century, Tanah Lot is a temple for lord of the sea, after a priest named Dang Hyang nirartha received revelation on a vast reef at the beraban village coast. Later, Tanah lot is considered a holy site and a favorite landmark for tourism. COVID-19 outbreak forced the local Government to close most public places on the island. On 20 July 2020, Tabanan regent decided to reopen five out of many tourism objects in its area, including the coastal landmark. Since reopening, its number of visits spiked rapidly, over twenty thousand visits in less than a month. Despite its huge demand, it did not significantly impact the economic atmosphere around the area. The management explained that the hawkers believed tourist visits were relatively low compared to before the pandemic. They argued the visitor purchasing power might also go down. The other reasons were that some stall owners terminated their contracts, and some preferred to sell from their homes.
A Review on nano-emulsion based gel formulations: emulgel, technology and recent advances
Authors: Gupta Prashant , Patel Dipti 
Published: February 2022

Dermatological products are being used for treating skin infections and pain /inflammation related disease from ancient times. The topical drug delivery provides many advantages over the other routes of drug administration. Apart from conventional dosage forms like creams, powders, lotions, gels, ointments, researchers are exploring new modifications in the dosage form for improved drug penetrations and enhanced pharmacodynamic activity of poorly absorbed drugs from the skin. Existing topical formulations are associated with the problems like stability, stickiness, irritation, lower spreadability, limited drug permeability and absorption. Formulation of Nano-emulsion based gels (Emulgel) is proved to be prominent approach for overcoming the barriers associated with the conventional dosage forms. Emulgels are prepared by screening oils, surfactant and co-surfactant on the basis of drug solubility. Nano-Emulsion is prepared using suitable techniques and then embedded into the gel matrix for skin application. Drug present in the oil portion in the micelles form (less than 500nm globule size) provides more area for absorption thereby more penetration and therapeutic activity. Emulgel processes desirable properties like greaseless, spreadability, emollient, non-staining, good consistency and improved organoleptic characteristics. Permeations enhancers are also explored for enhancing the penetration of drug incorporated in the Emulgel.
Formulation of Self-micro Emulsifying Drug Delivery Systems (SMEDDS) of Paclitaxel utilizing factorial design
Authors: Baghel Pragya , Roy Amit , Verma Shekhar , Satapathy Trilochan , Bahadur Sanjib 
Published: February 2022

Background: The antineoplastic drugs possess poor aqueous solubility along with low bioavailability. This limits delivery of antineoplastic drugs through oral route. SMEDDS is a well-accepted means for addressing the lower aqueous solubility and bioavailability issues of a lipophilic drugs. Paclitaxel (PTX) is an antineoplastic drug. PTX is found to be very useful in the treatment of ovarian and breast cancers. PTX have very low aqueous solubility (0.3 µg/ml).
Objective: This study aims to formulate SMEDDS incorporating PTX to enhance its aqueous solubility.
Methodology: Isopropyl myristate (IM), tween 80 (T80) and transcutol (TC) were used to formulate SMEDDS. IM was considered as oil, T80 as surfactant and TC as co surfactant. 32 factorial design analysis helps in studying the effect of an independent factor on a dependent factor on statistical principles. Independent factors, first – concentrations of oil, second – mixture of surfactant and co-surfactant (Smix), and two dependent factors, first – emulsification time and second – in vitro drug release were chosen. All the nine formulated B1-B9 were subjected to various physicochemical tests.
Result and discussion: The globule size was found to be 136.38 – 223.14 nm, zeta potential ranges between -31.54 to -7.58, drug content ranges between 65.34 – 83.56%. Statistical analysis shows that an increasing amount of surfactant decreases emulsification time. This may also decrease the average droplet size of resultant SMEDDS. When the concentration of tween 80 was increased, it was observed that the release of PTX also increased. Rapid and more extent of PTX released from formulated SMEDDS indicates that the aqueous solubility of PTX has increased. B9 formulation releases 99.46% PTX at end of 60 minutes whereas 35.23% of pure PTX powder was solubilized in dissolution medium.
Conclusion: This study states that the prepared SMEDDS possess acceptable properties to be considered as immediate release dosage forms. This conclusion was drawn based on in vitro release study.
Effect of Capecitabine Resealed Erythrocytes on MNU Induced Hepatocarcinogenesis in Swiss Albino Mice
Authors: CHIVATE ANURADHA , PRATIBHA S. SALVE  , RAJENDRA C. DOIJAD  , AVINASH M. MANE  , NIRANJAN D. CHIVATE  
Published: February 2022

Rationale of the study: Capecitabine is potential anticancer prodrug approved for colorectal cancer and metastatic breast cancer. It has short half life and several adverse effects due to which was encapsulated in erythrocytes for the treatment of hepatocellular carcinoma to observe and compare the effect of formulation with that of plain drug.
Introduction: The hepatoprotective potential of Capecitabine resealed erythrocytes was evaluated using MNU induced hepatocarcinogenesis in swiss albino mice model of 4 weeks.
Methodology: In present study, the effects of formulation and plain drug with respect to body weight, haematological parameters, biochemical parameters and histopathological study were evaluated and compared.
Results: Formulation restored the normal body weight and liver architecture with slight differences. Except platelets and neutrophils, no significant differences were observed in haematological parameters. The values of antioxidant enzymes (SOD, Catalase) and AFP were also restored more with formulation than plain drug though with no statistical differences when compared with normal control. Also it reduced the lipid peroxidation in the liver in treated group Vs induced group.
Conclusion: All these findings demonstrated hepatoprotective and anticancer effect of Capecitabine Resealed Erythrocytes (CRE) and suggested the use of this sustained release formulation in cancer chemoprevention.