bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating anti-müllerian hormone in a cohort-study of women with severe obesity with and without polycystic ovary syndrome and the effect of a one-year weight loss intervention
Authors: Kataoka Josefin , Larsson Ingrid , Lindgren Eva , Kindstrand Li Oskarson , Schmidt Johanna , Stener-Victorin Elisabet 
Published: August 2022

Abstract
Background
Women with polycystic ovary syndrome (PCOS) have high circulating anti-Müllerian hormone (AMH) levels which is correlated with antral follicle count and polycystic ovarian morphology and negatively correlated with body mass index (BMI). Moreover, diet-induced weight loss in women with PCOS and overweight or obesity, reduce or normalize AMH-levels. There is, however, no previous study investigating the circulating AMH levels in women with severe obesity and how a structured diet-induced weight loss program affects circulating AMH levels in these women. Therefore, this study aims to investigate circulating AMH levels in a population of women with severe obesity (BMI ≥ 35 kg/m2) with and without PCOS, as diagnosed by the NIH-criteria, and to investigate the effect of a one-year weight loss program with a very low-energy diet (VLED) on circulating levels of AMH.
Methods
In a prospective cohort-study, were 246 severely obese women screened for PCOS diagnosis with the NIH-criteria. Circulating AMH and anthropometry were measured at baseline and after a 12-month weight loss intervention with very low-energy diet (VLED).
Results
Mean BMI was 39.9 ± 4.7 (PCOS), 39.6 ± 4.3 (non-PCOS) P = 0.960. Circulating AMH was higher in women with PCOS (5.47 ± 4.89 µg/L) compared with non-PCOS (2.66 ± 3.71 µg/L) P < 0.001 and was positively correlated with circulating total testosterone in both groups. Next we performed ROC-analyses, and show that circulating AMH could not discriminate women with PCOS and severe obesity from non-PCOS women with severe obesity. Finally, a one-year weight reduction program does not affect circulating AMH levels despite significant weight loss neither in women with PCOS, nor without PCOS and severe obesity.
Conclusion
Women with severe obesity and PCOS have elevated levels of circulating AMH compared to women without the syndrome. AMH-levels could not discriminate women with PCOS from non-PCOS because of low sensitivity and specificity. Significant weight loss was not associated with changes in circulating AMH levels, neither in women with, nor without PCOS and severe obesity. These results imply that in women with severe obesity, a greater weight loss may be needed to improve reproductive features, independent of PCOS diagnosis.
Trial registration number:
Clinical trial.gov: NCT01319162.
Postoperative inpatient exercise facilitates recovery after laparoscopic surgery in colorectal cancer patients: a randomized controlled trial
Authors: Min Jihee , An Ki-yong , Park Hyuna , Cho Wonhee , Jung Hye Jeong , Chu Sang Hui , Cho Minsoo , Yang Seung Yoon , Jeon Justin Y. , Kim Nam Kyu 
Published: August 2022

Abstract
Purpose
The primary objective was to determine the efficacy of a postoperative exercise program on postsurgical recovery of stage I–III colorectal cancer patients.
Method
We randomly allocated participants to postoperative exercise or usual care (1:1 ratio). The postoperative exercise intervention consisted of 15 minutes of supervised exercise two times per day for the duration of their hospital stay. The primary outcome was the length of stay (LOS) at the tertiary care center. Secondary outcomes included patient-perceived readiness for hospital discharge, anthropometrics (e.g., muscle mass), and physical function (e.g., balance, strength).
Results
A total of 52 (83%) participants (mean [SD] age, 56.6 [8.9] years; 23 [44%] male) completed the trial. The median LOS was 6.0 days (interquartile range; IQR 5–7 days) in the exercise group and 6.5 days (IQR 6–7 days) in the usual-care group (P = 0.021). The exercise group met the targeted LOS 64% of the time, while 36% of the usual care group met the targeted LOS (colon cancer, 5 days; rectal cancer, 7 days). Participants in the exercise group felt greater readiness for discharge from the hospital than those in the usual care group (Adjusted group difference = 14.4; 95% CI, 6.2 to 22.6; P < 0.01). We observed a small but statistically significant increase in muscle mass in the exercise group compared to usual care (Adjusted group difference = 0.63 kg; 95% CI, 0.16 to 1.1; P = 0.03).
Conclusion
Postsurgical inpatient exercise may promote faster recovery and discharge after curative colorectal cancer surgery.
Motivational factors influencing readiness to use youth friendly services among secondary school students in East Belesa district, using the Theory of Planned Behavior, 2022
Authors: Tsegaw Menen , Kassie Ayenew , Alemnew Wallelign 
Published: August 2022

Abstract
Background: Youth refers to people aged between 15 and 24 years. The reproductive health of youth has become a major public health concern. The utilization of youth friendly services is low among Ethiopian school youths. Intention is the best predictor of behavior. However, there is no study done on the area which assesses the intention of the school youths to use youth friendly services. Therefore, this study is aimed to assess intention to use youth friendly services and associated factors among secondary school students in East Belesa.Objectives: This study was aimed to estimate the average intention to use youth friendly services and its factors among secondary school students in East Belesa district, using the Theory of Planned Behavior, 2022.Methods: An institution based cross-sectional study was conducted from May 23 to June 12, 2022 in East Belesa district. Stratified random sampling technique was used. Data was entered using EpiData version4.6 and analyzed using STATA version 14. Standardized β and R2 values were used to interpret effects and variability with intention to use youth friendly services respectively. Simple and Multiple linear regression analysis were performed. Statistical significance was declared at a p-value of <0.05 with 95% confidence interval.Results: A total of 511 respondents participated in the study giving a response rate of 99.8%. Around half of the participants were males (52.8%). The mean score of intention to use youth friendly services was 3.39±1.14. Direct perceived behavioral control (β = 0.25, 95%CI: 0.05, 0.45), subjective norm (β = 0.28: 95%CI: 0.09, 0.47), attitude (β = 0.20; CI: 0.03, 0.36), educated mothers (β = 1.65, 95%CI: 0.21, 3.09) and female sex (β = -1.77; 95% CI: -3.10, -0.44) were significant predictors of intention to use youth friendly services.Conclusion: the magnitude of intention to use youth friendly services was low. Perceived behavioral control, attitude, subjective norm, educated mothers and sex were the predictors of intention to use youth friendly services. The study informed that the theory of planned behavior could be applied to predict intention of youths to use youth friendly services.
Shortened ovarian stimulation duration may not affect oocyte developmental competence: a retrospective study
Authors: Yuan Lina , Han Ying , Lv Jiabei , Wang Xinyan , Zhang Yunshan , Zhang Yinfeng , Zhang Shuai , Xiao Nan , Luo Haining 
Published: August 2022

Abstract
Background: In recent years, an increasing number of scholars have begun to pay attention to the effect of gonadotropin (Gn) on the quality of oocytes and embryos. Some studies have focused on the relationship between Gn time and in vitro fertilization (IVF) outcomes. The aim of this study was to evaluate the effect of shortened ovarian stimulation duration on oocyte developmental competence during an IVF cycle.Methods: A total of 1049 women undergoing first IVF cycles between January 2019 and December 2021 were included in this retrospective cohort study. The populations were stratified according to ovarian reserve. Polycystic ovary syndrome (PCOS) diagnosed by the Rotterdam criteria and diminished ovarian reserve (DOR), defined by the Bologna criteria. Criteria for normal ovarian reserve (NOR) are AMH levels > 1.4 ng/ml and AFC 7~20. The women were further grouped according to the duration of ovarian stimulation. A total of 139 (26.4%) patients were in the NOR≤8 days group, 387 (73.6%) were in the NOR>8 days group, 82 (27.6%) were in the PCOS≤8 days group, 215 (72.4%) were in the PCOS>8 days group, 54 (23.9%) were in the DOR≤7 days group, and 172 (76.1%) were in the DOR>7 days group. Oocyte development-related factors including oocyte retrieval rate, oocyte maturation rate, normal fertilization rate and normal cleavage rate were analysed. A generalized linear model was used to explore the association between ovarian stimulation duration and oocyte developmental competence.Results: The oocyte retrieval rate, oocyte maturation rate, normal fertilization rate and normal cleavage rate were not affected by shortened ovarian stimulation duration in any of the ovarian reserve populations. Although there were differences in baseline characteristics and ovarian stimulation-related factors among the groups, the results remained robust after we adjusted for these potential confounding factors using generalized linear model analysis.Conclusions: We did not find that a shortened duration of ovarian stimulation impaired oocyte developmental competence in any population. Shortened stimulation duration is not predictive of suboptimal results.
Difficulties in the Treatment of Complications and Rehabilitation after COVID-19. A Clinical Case
Authors: Andreichenko S. A. , Slepukhina M. A. , Bychinin M. V. , Klypa T. V. , Atamanova M. A. , Shirinsky V. G. , Karapetyan G. E. 
Published: August 2022

The severe course of the new coronavirus infection (COVID-19) is associated with multiple life-threatening complications that lead to delayed initiation of active rehabilitation and unfavorable long-term treatment outcomes. Tracheoesophageal fistula is one of these complications. The specific feature of this event in COVID-19 is delayed tissue regeneration which requires a non-standard approach to management of such patients.The article presents a clinical case of a pregnant patient after a complicated severe course of COVID-19 with the development of tracheoesophageal fistula, sepsis, and weakness syndrome acquired in ICU. The combination of complications of the disease led to a prolonged (about five months) period of rehabilitation.Modern standard components of intensive therapy of such patients including regular monitoring of endotracheal/tracheostomy tube cuff pressure, dynamic assessment of nutritional status and its correction, rational antimicrobial therapy, screening of psychiatric disorders and early rehabilitation, will minimize the number of both early and delayed complications of COVID-19.
The Beauty in Art as a Gateway to the Appearance of the Truthfulness of Existence. "On Beauty and Being: Hans-Georg Gadamer’s and Virginia Woolf’s Hermeneutics of the Beautiful", by Małgorzata Hołda, Peter Lang GmbH, Berlin 2021, pp. 310 (rev.)
Authors: Rashelbach Hovav 
Published: August 2022

The book develops the current hermeneutic discourse concerning the notions of beauty and Being. It includes a discussion of melancholic beauty and its interconnection with the act of art’s creation. According to M. Hołda, the writings of both authors demonstrate a treatment of beauty based on ancient Greek thought, especially from the times of Plato and Aristotle. Gadamer reaffirms the intimate relationship between beauty and Being, which is also revealed in Woolf’s literary work.
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Received: 08/04/2022. Reviewed: 13/05/2022. Accepted: 14/06/2022.
The Association of Latitude and Altitude with COVID-19 Symptoms: A VIRUS: COVID-19 Registry Analysis
Authors: Tekin Aysun , Qamar Shahraz , Bansal Vikas , Surani Salim , Singh Romil , Sharma Mayank , LeMahieu Allison M. , Hanson Andrew C. , Schulte Phillip J. , Bogojevic Marija , Deo Neha , Sanghavi Devang K. , Cartin-Ceba Rodrigo , Jain Nitesh K. , Christie Amy B. , Sili Uluhan , Anderson Harry L. , Denson Joshua L. , Khanna Ashish K. , Zabolotskikh Igor Borisovich , La Nou Abigail T. , Akhter Murtaza , Mohan Surapaneni Krishna , Dodd Kenneth W. , Retford Lynn , Boman Karen , Kumar Vishakha K. , Walkey Allan J. , Gajic Ognjen , Domecq Juan Pablo , Kashyap Rahul 
Published: August 2022

Background:
Better delineation of COVID-19 presentations in different climatological conditions might assist with prompt diagnosis and isolation of patients.

Objectives:
To study the association of latitude and altitude with COVID-19 symptomatology.

Methods:
This observational cohort study included 12267 adult COVID-19 patients hospitalized between 03/2020 and 01/2021 at 181 hospitals in 24 countries within the SCCM Discovery VIRUS: COVID-19 Registry. The outcome was symptoms at admission, categorized as respiratory, gastrointestinal, neurological, mucocutaneous, cardiovascular, and constitutional. Other symptoms were grouped as atypical. Multivariable regression modeling was performed, adjusting for baseline characteristics. Models were fitted using generalized estimating equations to account for the clustering.

Results:
The median age was 62 years, with 57% males. The median age and percentage of patients with comorbidities increased with higher latitude. Conversely, patients with comorbidities decreased with elevated altitudes. The most common symptoms were respiratory (80%), followed by constitutional (75%). Presentation with respiratory symptoms was not associated with the location. After adjustment, at lower latitudes (<30º), patients presented less commonly with gastrointestinal symptoms (p<.001, odds ratios for 15º, 25º, and 30º: 0.32, 0.81, and 0.98, respectively). Atypical symptoms were present in 21% of the patients and showed an association with altitude (p=.026, odds ratios for 75, 125, 400, and 600 meters above sea level: 0.44, 0.60, 0.84, and 0.77, respectively).

Conclusions:
We observed geographic variability in symptoms of COVID-19 patients. Respiratory symptoms were most common but were not associated with the location. Gastrointestinal symptoms were less frequent in lower latitudes. Atypical symptoms were associated with higher altitude.
A Technical process of phytoconstituents extraction using Hydrotropes: Green and Sustainable Approach
Authors: Tripathi Devika , Raman Sunil Kumar , Mishra Sangeeta , Sahoo Jagannath 
Published: August 2022

Background:
The design of green and sustainable extraction methods of natural products is currently a prime topic in the multidisciplinary area of applied chemistry, biology, and technology, with the growing consumer demand for greener alternatives that do not involve any chemicals and industry concerns of sustainable, nontoxic extraction routes, the application of novel extraction technologies in the drug industry have been widely studied.
Hydrotrope has fewer toxic effects, is economically friendly, and is independent of pH. These compounds can enhance the bioavailability, solubility, dissolution, extraction yield, and purity of extracted phytoconstituents.

Conclusion:
The recent review illustrates the extensive references to the novel extraction of Phyto active compounds through hydrotrope and depicts the summary of updated extraction technologies. The technique is recent, simple, less expensive, and environmentally advantageous. Updated advanced extraction methods like ultrasound-assisted hydrotropic extraction (UAHE), microwave-assisted hydrotropic extraction (MAHE), and ultrasonic microwave-assisted hydrotropic extraction (UMAHE) have been considered a clean, green, and efficient alternatives to conventional extraction technologies. The active phytoconstituents extraction using hydrotrope with advanced extraction technologies has claimed to enhance the extraction yield up to 99% compared with the extraction involving organic solvent of such bioactive. Consequently, when carried out at a reduced temperature, hydrotropic extraction provided a higher extraction yield in a lesser time and maintained the purity of phytoconstituents.
The Factors Influencing Older Adults’ Decisions Surrounding Adoption of Technology: Quantitative Experimental Study
Authors: Moxley Jerad , Sharit Joseph , Czaja Sara J 
Published: August 2022

Background
The rapid diffusion of technology apps may support older adults’ independence and improve the quality of their lives. Models for predicting technology acceptance in older adults are sparse, based on broad questions related to general technology acceptance, and largely not grounded in theories of aging.

Objective
This study aimed to use a mixed methods approach involving 5 technologies to comprehensively assess the causal relationships among factors that influence older adults’ willingness to adopt the technologies.

Methods
In total, 187 men and women aged 65 to 92 years participated in the study. Participants were given presentations on 5 different technologies spanning domains that included transportation, leisure, health, and new learning and provided ratings of each technology on various measures hypothesized to influence adoption. They were also administered other instruments to collect data on their actual and self-assessed cognitive abilities, rates of discounting of the technologies with respect to willingness to invest time to attain higher skills in the technologies, general technology experience, and attitudes toward technology. We used the machine learning technique of k-fold cross-validated regressions to select variables that predicted participants’ willingness to adopt the technologies.

Results
Willingness to adopt technologies was most impacted by 3 variables: perceived value of the technologies (β=.54), perceived improvement in quality of life attainable from the technologies (β=.24), and confidence in being able to use the technologies (β=.15). These variables, in turn, were mostly facilitated or inhibited by the perceived effort required to learn to use the technologies, a positive attitude toward technology as reflected in the optimism component of the technology readiness scale, the degree to which technologies were discounted, and the perceived help needed to learn to use the technologies.

Conclusions
Our findings demonstrate that participants’ willingness to adopt technologies is mainly determined by perceptions of 3 aspects of the technologies; these aspects possibly mediate many relationships with willingness to adopt. We discuss the implications of these findings for the design and marketing of technology products for older consumers.
Cost–effectiveness analysis of pembrolizumab for patients with advanced esophageal cancer at PD-L1 combined positive score ≥10
Authors: Xie Qian , Luo Yaxin , Peng Xingchen 
Published: August 2022

Aim:
Due to the high price of pembrolizumab, it is still unknown whether the use of pembrolizumab for advanced esophageal cancer would be a cost-effective option for patients whose PD-L1 combined positive score is ≥10.
Methods:
A Markov simulation model was performed based on clinical trial KEYNOTE-181. Incremental cost–effectiveness ratios were calculated to compare the two treatments.
Results:
The total costs were US$193,575.60 and $8789.24 for pembrolizumab and chemotherapy treatment, respectively. The pembrolizumab group produced 0.93 quality-adjusted life years (QALYs), while the chemotherapy group produced 0.58 QALYs. Thus, patients in the pembrolizumab group spent an additional US$184,786.36 and produced 0.35 QALYs more than the chemotherapy group, which resulted in an incremental cost–effectiveness ratio of US$527,961.03 per QALY.
Conclusion:
For patients with advanced esophageal cancer whose PD-L1 combined positive score is ≥10, pembrolizumab is not a cost-effective second-line therapy versus chemotherapy from the US payer perspective.
Sick Leave in Colombia in the 2016–2018 period: A Retrospective Cross-Sectional Observational Study
Authors: Valero-Pacheco Ivonne Constanza , Riaño-Casallas Martha I. , Garcia-Bedoya Olmer , Rodriguez-Paez Fredy G. , Cardona Fabián , Téllez-Avila Eliana M. , Palma-Parra Ruth M. 
Published: August 2022

Introduction: To understand the sick leave situation and the causes and effects of a temporary loss of capacity to work allows for the strengthening of policies and management in the provision of health services. Objective: To analyze sick leave in Colombia in the 2016–2018 period. Materials and methods: A retrospective cross-sectional observational study and the relative risk was calculated. Sick leave reports were provided by the Ministry of Health and Social Protection. 12,410,837 reports from formal workers between the ages of 18–70 years and had at least one temporary disability were processed. Results: The average age of people with sick leave was 37.11 years, 53% corresponding to females. On average, sick leave was 90.6% and 5.6% for dependent and independent workers, respectively. The principal causes of disability were musculoskeletal diseases and were more likely in men and adults according to RR. Men in comparison to females and adults in comparison to youths are less likely to have sick leave due to respiratory disease. Conclusions: In Colombia, females presented more temporary sick leave, even if males had more days of disability, even though the median was three days in both genders. Youth and adults had more sick leave days.
Thinking Process Analysis (Assimilation, Accommodation, Abstraction) Mathematics Ability of Junior High School Students in terms of Learning Style
Authors: Susanti Susanti , Utami Fathia , Alkiram Shaheb , Mubarrak Muhammad Zaki 
Published: August 2022

The purpose of this research is to know the thinking processed of student’s mathematical literacy abilities in terms of auditory, visual and kinesthetic learning styles. This research is an exploratory study with a qualitative approach. This research was conducted in Junior High Schools classified as Excellent in Meulaboh Regency. The subjects in this study were students of class IX MTsN 3 Aceh Barat who had the high-level ability and were able to solve math literacy problems, besides the subject was also chosen based on learning styles. The results showed that there was no significant difference in students mathematical literacy thinking processes based on visual learning styles is the process of assimilation and abtarksi thinking. Subjects with auditory learning styles, the thought processes of accommodation and abstraction for the kinesthetic learning styles, the processes of thinking, assimilation and abstraction.