bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transformation processes in the recreation and tourism industry of European countries at the present stage
Authors: Volovyk Lyudmila 
Published: November 2022

The subject of the study is to find out the specifics of the influence of the transformational processes of the world economy on the development of the recreational and tourist industry of European countries and to take into account the experience of Ukraine. The purpose of the article is the scientific substantiation of theoretical and practical provisions regarding the development of the recreational and tourist industry of European countries in the context of modern transformational changes in the world economy. Research methods. General scientific and special methods of scientific knowledge of empirical and theoretical levels of research are used to study transformational processes in the recreational and tourist industry of European countries at the current stage of development. Results of the article. The article examines the peculiarities of the impact of transformational processes on the development of the recreational and tourist industry of European countries, studying their experience for practical implementation in Ukraine. Field of application of results. The results of the study can be used by enterprises of the recreation and tourism industry of Ukraine, institutions of higher education, united territorial communities of the country and all interested persons in this issue. Conclusions. The recreational and tourist industry of European countries is a priority direction for the development of their economies and cultures. The European region is the most attractive for tourists, and the countries of Western and Southern Europe are distinguished by the highest and most effective level of use of recreational and touristic potential. Rich natural recreational resources, a significant number of cities with historical, architectural monuments, artistic and cultural values attract about 59% of the planet's tourists. According to the World Tourism Organization, the leaders in the number of tourists and vacationers in Europe are France, Great Britain, Germany, Spain, Italy and Greece [3]. The experience of European countries proves that the participation of the state in the development of the recreational and tourist industry, where centralized regulation solves a number of problems of the spontaneous market economy in favor of the sustainable (balanced) development of this sphere of activity, is the most acceptable for Ukraine as well, since our country has a high level of provision of natural and historical and cultural values ​​for proper socio-economic development due to recreation and tourism, taking into account the fact that post-war economic reconstruction, as a result of Russian aggression, will last for years.
Halkla İlişkilerin Toplumsal Dönüştürücü Rolü Bağlamında Sürdürülebilirlik ve İklim Krizi Üzerine Bir Deneme
Authors: BALAY TUNCER Berrin 
Published: November 2022

toplumudur. Kaynağı doğal olmayan insan tarafından imal edilmiş(neden olunmuş) belirsizliklere işaret eden bu kavram ile iklim krizi ve buna bağlı doğacak olan ve hayatı derinden etkileyecek çok çeşitli riskleri kapsar. Bu çalışmada iklim krizinin etkilerini azaltmak amacıyla halkla ilişkilerin sosyo-kültürel yaklaşım bağlamında toplumsal değişmeyi sağlayan dönüştürücü rolü üzerine neler yapabiliriz? sorusuna yanıt aranacaktır. Sürdürülebilirlik, iklim krizi ve ortak geleceğimiz arasında halkla ilişkilerle bir ilişki kurmayı denemektir. Çalışmanın amacı; halkla ilişkilerin risk yönetimindeki rolü ve bu konuda halkta farkındalık yaratarak, ikna ederek koruyucu önleyici davranış değişiklikleriyle değişimi dönüşümü bireysel hayatlarımız kadar indirecek iletişim stratejileri üzerine odaklanmaktır. Çalışma literatüre taramasına dayanmaktadır. Risk iletişimi politikalarını oluşturacak olan hükümet, kurumlar gibi makro örgütlerdir. Ancak politikaları uygulamayı hayata geçirecek olan bireylerdir. Bu çalışma risklerin önlenmesinde bireyin dönüşümünü tartışılması açması nedeniyle alanyazına katkı sağlayabilir.
Anahtar Kelimeler: Halkla ilişkiler, risk toplumu, sosyo-kültürel yaklaşım, sürdürülebilirlik, Ulrich Beck.
Quality indicators for evaluating the 30-day postoperative outcome in pediatric brain tumor surgery: a 10-year single-center study and systematic review of the literature
Authors: Sletvold Truls P. , Boland Solveig , Schipmann Stephanie , Mahesparan Rupavatana 
Published: November 2022

OBJECTIVE
Surgery is the cornerstone in the management of pediatric brain tumors. To provide safe and effective health services, quantifying and evaluating quality of care are important. To do this, there is a need for universal measures in the form of indicators reflecting quality of the delivered care. The objective of this study was to analyze currently applied quality indicators in pediatric brain tumor surgery and identify factors associated with poor outcome at a tertiary neurosurgical referral center in western Norway.

METHODS
All patients younger than 18 years of age who underwent surgery for an intracranial tumor at the Department of Neurosurgery at Haukeland University Hospital in Bergen, Norway, between 2009 and 2020 were included. The primary outcomes of interest were classic quality indicators: 30-day readmission, 30-day reoperation, 30-day mortality, 30-day nosocomial infection, and 30-day surgical site infection (SSI) rates; and length of stay. The secondary aim was the identification of risk factors related to unfavorable outcome. The authors also conducted a systematic literature review. Articles concerning pediatric brain tumor surgery reporting at least two quality indicators were of interest.

RESULTS
The authors included 82 patients aged 0–17 years. The 30-day outcomes for unplanned reoperation, unplanned remission, mortality, nosocomial infection, and SSI were 9.8%, 14.6%, 0%, 6.1%, and 3.7%, respectively. Unplanned reoperation was associated with eloquent localization (p = 0.009), primary emergency surgery (p = 0.003), and CSF diversion procedures (p = 0.002). Greater tumor volume was associated with unplanned readmission (p = 0.008), nosocomial infection (p = 0.004), and CSF leakage (p = 0.005). In the systematic review, after full-text screening, 16 articles were included and provided outcome data for 1856 procedures. Overall, the 30-day mortality rate was low, varying from 0% to 9.3%. The 30-day reoperation rate varied from 1.5% to 12%. The SSI rate ranged between 0% and 3.9%, and 0% to 17.4% of patients developed CSF leakage. Four studies reported infratentorial tumor location as a risk factor for postoperative CSF leakage.

CONCLUSIONS
The 30-day outcomes in the authors’ department were comparable to published outcomes. The most relevant factors related to unfavorable outcomes are tumor volume and location, both of which are not modifiable by the surgeon. This highlights the importance of risk adjustment. This evaluation of quality indicators reveals concerns related to the unclear and nonstandardized definitions of outcomes. Standardized outcome definitions and documentation in a large and multicentric database are needed in the future for further evaluation of quality indicators.
Endoscopic endonasal optic nerve decompression: treatment of fibrous dysplasia in a pediatric population
Authors: Behbahani Mandana , Fernando Shanik , Peng Sophia , Fernandez Luis G. , Hajnas Natalia , Sharma Shelly , Rastatter Jeffrey C. , Alden Tord D. 
Published: November 2022

OBJECTIVE
Patients with fibrous dysplasia (FD) of the anterior skull base can experience progressive visual loss and impairment. The authors reviewed their experience with endonasal decompression of the optic nerve (ON) in this patient population. Endoscopic ON decompression (EOND) is a feasible surgical approach for children with FD and visual deficit due to structural ON compression.

METHODS
Electronic medical records of children between 1 and 17 years of age with unilateral FD of the anterior skull base and concomitant ON compression, who required EOND between 2017 and 2022 (n = 4), were reviewed for demographic data, both pre- and postoperative imaging, and evaluations by an otolaryngologist, neurosurgeon, and ophthalmologist in a multidisciplinary fashion.

RESULTS
EOND was found to be a safe and effective surgery for children with FD. Visual acuity was stable in 80% of the eyes postoperatively. Visual fields improved in 40% of the eyes and remained stable in the rest.

CONCLUSIONS
EOND is beneficial for progressive optic neuropathy that is unresponsive to steroid therapy and can prevent permanent disability if performed prior to irreversible damage to the nerve. EOND can decompress the edematous ON with proper exposure of the optic canal and orbital apex, without any major complications.
Care living instrument for neonatal infant connectivity solution (CliNicS) in smart environment
Authors: Sivasankari B. , Ahilan A. , Jeyam A. , Jasmine Gnanamalar A. 
Published: November 2022

Hyperbilirubinemia or jaundice occurs in 60% of healthy babies and 80% of preterm infants because of an increase in unconjugated bilirubin in red blood cells. It is subjective to determine the severity of jaundice by visual assessment of the skin color of a newborn, and clinical judgement is dependent on the doctor’s knowledge. The paper explains the development of a non-invasive bilirubin detection technique called CliNicS, to check the bilirubin level of premature babies and report premature births and deaths to the health organization via an IOT network. CliNicS provides a noninvasive, transcutaneous bilirubin monitoring system using LED having a wavelength of 410 nm to 460 nm, and it also provides the treatment automatically by using LCT (LED Controlled Therapy) method. The level of bilirubin will be detected by using the photo detector, and the bilirubin measurement will be displayed on the LCD display. The bilirubin levels will be transmitted to doctors and health organizations via the IOT network. The proposed method helps to detect neonatal jaundice earlier, which reduces the risk of hyperbilirubinemia in newborns and makes it easier to measure total serum bilirubin levels than ever before.
Pelatihan Teknologi Akuaponik Dengan Sistem Budikdamber Sebagai Upaya Menumbuhkan Minat Budi Daya Pada Remaja
Authors: Ulfah Iin Khoiriyah , Prasetyo Mohammad Ageng , Maulana Recky Indar 
Published: November 2022

Seiring berkembangnya teknologi, terdapat berbagai macam inovasi sistem budi daya bermunculan. Akuaponik merupakan gabungan teknologi budi daya ikan dan tanaman dalam satu wadah. Dibandingkan dengan budi daya konvensional, teknologi akuaponik memiliki lebih banyak keunggulan. Sayangnya, kemajuan teknologi ini tidak sejalan dengan ketersediaan sumber daya manusia yang mumpuni. Remaja yang menjadi tonggak kemajuan sering menganggap bahwa pertanian dan perikanan adalah pekerjaan para orang tua sehingga tidak sesuai dengan mereka. Oleh karena itu, pelatihan akuaponik dengan sistem Budikdamber ini diselenggarakan dengan mengajak remaja di Desa Jambewangi untuk dapat meningkatkan pengetahuan tentang cara budi daya ikan dan tanaman yang terintegrasi melalui sosialisasi dan praktik lapangan. Tujuannya adalah untuk menumbuhkan minat budi daya sehingga dapat turut andil dalam pengembangan inovasi terhadap potensi yang dimiliki daerahnya. SDM yang cerdas, berdaya guna dan berpotensi dapat memaksimalkan segala potensi dan kesempatan di sekitarnya, karena SDM yang berkualitas merupakan faktor penting dalam kemajuan suatu bangsa.
Fibroblast growth factor 2 is a druggable target against glioblastoma: A computational investigation
Authors: Siddique Rabeea , Abideen Syed Ainul , Nabi Ghulam , Awan Faryal Mehwish , Noor Khan Sadiq , Ullah Fawad , Khan Suliman , Xue Mengzhou 
Published: November 2022

Fibroblast growth factor 2 (FGF2) is a key player in cancer and tissue homeostasis and regulates renewal of several stem cell types. The FGF2 role in malignant glioma is proven and tagged FGF2, a novel druggable target, is used for developing potent drugs against glioblastoma. In this study, Asinex 51412372, Asinex 51217461, and Asinex 51216586 were filtered to show the best binding affinity for FGF2 with binding energy scores of −8.3 kcal/mol, −8.2 kcal/mol, and −7.8 kcal/mol, respectively. The compounds showed chemical interactions with several vital residues of FGF2 along the compound length. The noticeable residues that interacted with the compounds were Arg15, Asp23, Arg63, and Gln105. In dynamic investigation in solution, the FGF2 reported unstable dynamics in the first 100 ns and gained structural equilibrium in the second phase of 100 ns. The maximum root mean square deviation (RMSD) value touched by the systems is 3 Å. Similarly, the residue flexibility of FGF2 in the presence of compounds was within a stable range and is compact along the simulation time length. The compounds showed robust atomic-level stable energies with FGF2, which are dominated by both van der Waals and electrostatic interactions. The net binding energy of systems varies between −40 kcal/mol and −86 kcal/mol, suggesting the formation of strong intermolecular docked complexes. The drug-likeness and pharmacokinetic properties also pointed toward good structures that are not toxic, have high gastric absorption, showed good distribution, and readily excreted from the body. In summary, the predicted compounds in this study might be ideal hits that might be further optimized for structure and activity during experimental studies.
Pyrazolyl-s-triazine with indole motif as a novel of epidermal growth factor receptor/cyclin-dependent kinase 2 dual inhibitors
Authors: Shawish Ihab , Nafie Mohamed S. , Barakat Assem , Aldalbahi Ali , Al-Rasheed Hessa H. , Ali M. , Alshaer Walhan , Al Zoubi Mazhar , Al Ayoubi Samha , De la Torre Beatriz G. , Albericio Fernando , El-Faham Ayman 
Published: November 2022

A series of pyrazolyl-s-triazine compounds with an indole motif was designed, synthesized, and evaluated for anticancer activity targeting dual EGFR and CDK-2 inhibitors. The compounds were tested for cytotoxicity using the MTT assay. Compounds 3h, 3i, and 3j showed promising cytotoxic activity against two cancer cell lines, namely A549, MCF-7, and HDFs (non-cancerous human dermal fibroblasts). Compound 3j was the most active candidate against A549, with an IC50 of 2.32 ± 0.21 μM. Compounds 3h and 3i were found to be the most active hybrids against MCF-7 and HDFs, with an IC50 of 2.66 ± 0.26 μM and 3.78 ± 0.55 μM, respectively. Interestingly, 3i showed potent EGFR inhibition, with an IC50 of 34.1 nM compared to Erlotinib (IC50 = 67.3 nM). At 10 μM, this candidate caused 93.6% and 91.4% of EGFR and CDK-2 inhibition, respectively. Furthermore, 3i enhanced total lung cancer cell apoptosis 71.6-fold (43.7% compared to 0.61% for the control). Given the potent cytotoxicity exerted by 3i through apoptosis-mediated activity, this compound emerges as a promising target-oriented anticancer agent.
Neurocognitive function in patients with atrial fibrillation undergoing pulmonary vein isolation
Authors: Zwimpfer Leon , Aeschbacher Stefanie , Krisai Philipp , Coslovsky Michael , Springer Anne , Paladini Rebecca E. , Girod Marc , Hufschmid Janik , Knecht Sven , Badertscher Patrick , Beer Jürg H. , Bonati Leo H. , Zuern Christine S. , Roten Laurent , Reichlin Tobias , Sticherling Christian , Conen David , Osswald Stefan , Kühne Michael 
Published: November 2022

BackgroundAtrial fibrillation (AF) is associated with cognitive dysfunction. However, neurocognitive function in AF patients undergoing pulmonary vein isolation (PVI) has not been well studied. The aim of this analysis is to compare neurocognitive function in patients who did or did not undergo PVI.Materials and methodsWe used data from the Swiss Atrial Fibrillation Cohort study (Swiss-AF), a prospective, observational, multicenter study in Switzerland. Patients with documented AF were enrolled and data of 1,576 patients without history of PVI and with complete information on PVI status and neurocognitive function were used. Information on PVI was collected at baseline and during 1 year of follow-up. Neurocognitive testing was performed at baseline and after 1 year of follow-up, using the Montreal Cognitive Assessment (MoCA), trail making test (TMT) A and B, digit symbol substitution test (DSST) and semantic fluency test (SFT). To investigate the association of PVI with neurocognitive function, we use propensity score matching (1:3) and inverse probability of treatment weighting (IPTW).ResultsThe mean age of this population was 74 ± 8 years, 27.1% were women. Overall, 88 (5.5%) patients underwent PVI during 1 year of follow-up. Using ITPW (n = 1576), PVI was weakly associated with the MoCA score after adjusting for time since PVI, baseline MoCA score and other covariates (β (95%CI) 1.19 (0.05; 2.32), p = 0.04). In the propensity matched comparison (n = 352), there was no significant association between PVI and the MoCA score (β (95%CI) 1.04 (−0.19; 2.28), p = 0.1). There were no significant associations between PVI and cognitive function when using the TMT A and B, DSST or SFT independent of the method used.ConclusionIn this population of AF patients, there was no consistent evidence of an association between PVI and neurocognitive function.Clinical trial registration[https://clinicaltrials.gov/], identifier [NCT02105844].
Predictors of adherence of enhanced external counterpulsation in patients with coronary heart disease after discharge: A mixed-methods study
Authors: Yin Yuhuan , He Qinli , Zhang Rong , Cheng Hu , Zhang Yiyin , Zhang Juxia 
Published: November 2022

BackgroundAlthough enhanced external counter pulsation (EECP) has been included in the cardiac rehabilitation prescription for coronary heart disease (CHD) in China, because the total treatment duration of a course of EECP is 36–36 h, the average hospital stay of CHD patients is short, and the adherence after discharge remains unclear. The purpose of this study is to investigate the adherence to EECP in CHD patients after discharge, and analyze the related influencing factors.MethodsA retrospective mixed method study combining qualitative and quantitative methods. Quantitative component included CHD patients who had received EECP treatment between March 2020 and August 2021. The qualitative component included in-depth interviews with patients who did not adhere to EECP after discharge. Binary Logistic regression was used to analyze the predictors of EECP adherence after discharge. In-depth interviews with patients were conducted to explore the reasons for dropping out of the EECP after discharge.ResultsAmong 1,304 patients, only 24.23% adhered to EECP treatment after discharge. Binary logistic regression results showed that patients with disease duration &lt; 2 years (OR = 3.13, 95%CI: 2.31–4.24), high school or below (OR = 2.81, 95%CI: 1.98–4.01), distance between residence and hospital more than 20km (OR = 2.08, 95%CI: 1.47–2.96), age over 60 (OR = 2.00, 95%CI: 1.46–2.74), female (OR = 1.64, 95%CI: 1.78–2.29), and angina pectoris (OR = 1.65, 95%CI: 1.16–2.34) were more likely to not adhere to EECP treatment after discharge. However, patients with monthly family income over 8000¥ (OR = 0.46, 95%CI: 0.28–0.75) were more likely to adhere to EECP treatment after discharge than those with household monthly income below 4,000¥. In the qualitative results, the reasons why patients do not adhere to EECP after discharge mainly include insufficient understanding, restricted objective conditions and psychosocial factors.ConclusionsThe adherence of CHD patients to EECP treatment after discharge was poor. It is necessary to develop effective intervention measures, such as brochures or videos to improve patients' understanding of the importance of adherence to EECP treatment after discharge. In addition, offering EECP treatment during off-hours and weekends may also improve adherence in more young patients.
Low-density lipoprotein-cholesterol lowering effect of a nutraceutical regimen with or without ezetimibe in hypercholesterolaemic patients with statin intolerance
Authors: Ward Natalie C. , Reid Christopher M. , Watts Gerald F. 
Published: November 2022

BackgroundStatins are the most widely prescribed medication to lower low-density lipoprotein cholesterol (LDL-c). However, a significant portion of patients are unable to tolerate them due to side effects, most commonly muscle related. Nutraceuticals, natural plant derivatives with lipid-lowering properties, may provide an alternative to lower LDL-c in these patients.AimsTo investigate whether a nutraceutical regimen, either alone or in combination with ezetimibe, can lower LDL-c in patients with hypercholesterolemia who are intolerant to statins.MethodsParticipants were recruited into a double-blind, randomized, placebo-controlled intervention study. Treatments were (i) placebo, (ii) nutraceutical (500 mg berberine, 200 mg red yeast rice (RYR), 2 g plant sterols)/daily, (iii) ezetimibe (10 mg)/daily, or (iv) the combination of nutraceutical and ezetimibe/daily. At baseline and week 8, all participants provide a fasting blood sample for assessment of lipid profile and safety bloods.ResultsFifty participants were randomized, with 44 completing the treatment period. Following adjustment for baseline levels and compared with placebo, LDL-c was significantly reduced (all p &lt; 0.0001) with ezetimibe (−1.02 mmol/L), nutraceutical (−1.15 mmol/L) and the nutraceutical and ezetimibe combination (−1.92 mmol/L). Non-HDL cholesterol was significantly reduced (all p &lt; 0.0001) with ezetimibe (−1.29 mmol/L), nutraceutical (−1.37 mmol/L) and the nutraceutical and ezetimibe combination (−2.18 mmol/L). Remnant cholesterol and triglycerides was significantly reduced with the nutraceutical and ezetimibe combination (p = 0.018).ConclusionA nutraceutical regimen (berberine, RYR and plant sterols) and ezetimibe independently and additively lower LDL-c in patients with hypercholesterolemia who are intolerant to statins.
A novel nomogram containing efficacy indicators to predict axillary pathologic complete response after neoadjuvant systemic therapy in breast cancer
Authors: Shi Wenjie , Huang Xiaofeng , Wang Ye , Wan Xinyu , He Jinzhi , Xu Yinggang , Zhang Weiwei , Chen Rui , Xu Lu , Zha Xiaoming , Wang Jue 
Published: November 2022

BackgroundNeoadjuvant systemic therapy (NST) could make some clinically node-positive (cN+) breast cancer patients achieve axillary pathologic complete response (pCR). This study aimed to identify the patients who are likely to achieve axillary pCR and help surgeons make surgical decisions on the axilla.MethodsThe cN+ breast cancer patients who received NST from 2015 to 2021 at The First Affiliated Hospital of Nanjing Medical University were enrolled. Univariate and multivariate logistic regression analyses were performed, and a nomogram was constructed based on the results of multivariate logistic regression analysis to predict the probability of axillary pCR and validated.ResultsThe axillary pCR was achieved in 208 (38.7%) patients. Patients who had a higher radiological response rate of breast tumor (P = 0.039), smaller longest diameter of positive node after NST (P = 0.028), ER-negative status (P = 0.006), HER2-positive status (P = 0.048) and breast pCR (P &lt; 0.001) were more likely to achieve axillary pCR. The nomogram had an area under the receiver operating characteristic curve (AUC) of 0.792 (95% CI: 0.744–0.839), and the calibration curve showed good agreement.ConclusionA nomogram was constructed to predict the axillary pCR of cN+ patients receiving NST based on baseline and efficacy indicators to assist surgeons in making surgical decisions on the axilla.