bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in high‐resolution mass spectrometry techniques for analysis of high mass‐to‐charge ions
Authors: Lai Yin‐Hung , Wang Yi‐Sheng 
Published: June 2022

AbstractA major challenge in modern mass spectrometry (MS) is achieving high mass resolving power and accuracy for precision analyses in high mass‐to‐charge (m/z) regions. To advance the capability of MS for increasingly demanding applications, understanding limitations of state‐of‐the‐art techniques and their status in applied sciences is essential. This review summarizes important instruments in high‐resolution mass spectrometry (HRMS) and related advances to extend their working range to high m/z regions. It starts with an overview of HRMS techniques that provide adequate performance for macromolecular analysis, including Fourier‐transform, time‐of‐flight (TOF), quadrupole‐TOF, and related data‐processing techniques. Methodologies and applications of HRMS for characterizing macromolecules in biochemistry and material sciences are summarized, such as top‐down proteomics, native MS, drug discovery, structural virology, and polymer analyses.
Metallomic and Untargeted Metabolomic Signatures of Human Milk from SARS‐CoV‐2 Positive Mothers
Authors: Arias‐Borrego Ana , Soto Cruz Francisco J. , Selma‐Royo Marta , Bäuerl Christine , García Verdevio Elia , Pérez‐Cano Francisco J. , Lerin Carles , Velasco López Inés , Martínez‐Costa Cecilia , Collado M. Carmen , García‐Barrera Tamara 
Published: June 2022

ScopeLack of information about the impact of maternal severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection on the elemental and metabolomic profile of human milk (HM).Methods and resultsAn observational study on HM from mothers with COVID‐19 is conducted including a prepandemic control group. Maternal–infant clinical records and symptomatology are recorded. The absolute quantification of elements and untargeted relative metabolomic profiles are determined by inductively coupled plasma mass spectrometry and gas chromatography coupled to mass spectrometry, respectively. Associations of HM SARS‐CoV‐2 antibodies with elemental and metabolomic profiles are studied. COVID‐19 has a significant impact on HM composition. COVID‐19 reduces the concentrations of Fe, Cu, Se, Ni, V, and Aluminium (Al) and increases Zn compared to prepandemic control samples. A total of 18 individual metabolites including amino acids, peptides, fatty acids and conjugates, purines and derivatives, alcohols, and polyols are significantly different in HM from SARS‐CoV‐2 positive mothers. Aminoacyl‐tRNA biosynthesis, phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine, and linoleic acid pathways are significantly altered. Differences are obtained depending on COVID‐19 symptomatic and asymptomatic status.ConclusionsThis study provides unique insights about the impact of maternal SARS‐CoV‐2 infection on the elemental and metabolomic profiles of HM that warrants further research due the potential implications for infant health.
Nocturnal enuresis in children: Parents' perspectives
Authors: Huang Wen‐Jiao , Liang Yuan‐Yuan , Yang Qian , Ma Xue 
Published: June 2022

AbstractAimParents of children with nocturnal enuresis (NE) may have uncertainty and anxiety. This study aimed to investigate the level of uncertainty and anxiety in the parents of children with NE and analyse its influencing factors.DesignWe conducted a descriptive cross‐sectional study among the parents of children with NE in China.MethodsA general information questionnaire, the Parent Perception of Uncertainty Scale (PPUS), and the Self‐Rating Anxiety Scale (SAS) were used. Multiple linear regression analysis was used to identify factors influencing the parental uncertainty level independently.ResultsA total of 247 valid questionnaires were collected. The PPUS score of children with NE was 81.18 ± 10.82, and the anxiety self‐rating scale score was 41.86 ± 9.20. Parents' working status, the family’s per capita monthly income, and the children’s treatment time were the main influencing factors of parental illness uncertainty.
Engaging nursing students in a COVID‐19 Point‐of‐Care rapid screening clinic
Authors: Dhari Ranjit , Haase Kristen , Ranger Manon , Tan Elsie , Affleck Frances , Bailey Elisabeth , Wong Sabrina T. 
Published: June 2022

AbstractBackgroundThe COVID‐19 pandemic has globally impacted nursing education, particularly clinical learning opportunities for undergraduate nursing students.PurposeIn this paper, we report on an educational activity wherein students participated in a COVID‐19 Rapid Antigen Testing (RAT) clinic on a Canadian university campus.MethodsBetween February–April 2021, in the second term of a five‐term accelerated program, nursing students (n = 60) participated in a nurse‐led COVID‐19 RAT clinic for students and staff living or working in congregate housing. Students participated in education activities which exposed nursing students to the full range of community health nursing roles in a pandemic.ResultsFrom clinical, research, policy, and public health, this educational activity acted as a microcosm of the critical roles that nurses employ in the health ecosystem.ConclusionWe offer lessons learned about implementing this activity, and how these lessons can be applied to routine and exceptional nursing curriculum.
Graves, landmarks, or sacrificial monuments? The human osteology and paleopathology of the Bronze Age burial cairns in Finland
Authors: Salo Kati , Saipio Jarkko , Hentunen Maddie , Mannermaa Kristiina , Oinonen Markku 
Published: June 2022

AbstractDuring the Bronze Age (BA; ca. 1800–500 BC), cremation became the dominant burial practice in Finland. These BA cremations have been excavated from burial cairns in Finland for more than 150 years. This work provides new information on human osteology from this previously understudied area in northeastern Europe. The results cover the earliest period in Finnish prehistory for which large‐scale human osteological assemblages are available. In this article, we present a comprehensive human osteological study on the curated bone collections of the National Museum of Finland and other provincial museums and provide new radiocarbon datings of the cairns. The results show that the cairns were most often used for single burials, without accompanying animals or artifacts. Double and multiple burials became more common in the Iron Age. Porotic hyperostosis was a common finding. Signs of osteoarthritis are more common in the central Satakunta region, where Iron Age burial practices first emerged already during the Late BA. These observed changes can be connected to changes in subsistence strategies that also enabled permanent settlements.
Perinatal outcomes of pregnancies with twin‐anemia polycythemia sequence complicating twin‐to‐twin transfusion syndrome using different twin‐anemia polycythemia sequence diagnostic criteria
Authors: Mustafa Hiba J. , Cermak Rachel , Pedersen Nicole , Harman Christopher , Turan Ozhan M. 
Published: June 2022

AbstractObjectiveTo investigate whether the presence of twin‐anemia polycythemia sequence (TAPS) with twin‐to‐twin transfusion syndrome (TTTS) or post‐laser TAPS would change outcomes using different TAPS diagnostic criteria.MethodsTTTS cases undergoing laser surgery between 2012 and 2020 were included. Groups included pre‐laser TTTS‐only compared to TTTS + TAPS, and no post‐laser TAPS compared to post‐laser TAPS. Three prenatal TAPS diagnostic criteria were used: group A: middle cerebral artery‐peak systolic velocity (MCA‐PSV) > 1.5 MoM in one twin and <1 MoM in the other twin, group B: inter‐twin MCA‐PSV difference >1 MoM, and group C: inter‐twin MCA‐PSV difference >0.5 MoM. Perinatal outcomes including survival and severe cerebral injury were investigated.Results174 laser procedures were included. TTTS + TAPS cases were 16 in group A, 17 in group B, and 29 in group C. Post‐laser TAPS cases were 11 in group A, 6 in group B, and 12 in group C. There were no differences in preoperative, operative variables and outcomes including survival and severe cerebral injury between groups using all three TAPS diagnostic criteria. The incidence of TTTS + TAPS was highest in group C (16.7%), then group B (9.8%), followed by group A (9.2%). The incidence of post‐laser TAPS was highest in group C (9%), then group A (8.3%), followed by group B (4.5%).ConclusionPresence of TAPS complicating TTTS and presence of post‐laser TAPS do not seem to be associated with worse perinatal outcomes including postnatal‐ultrasound detected cerebral injury using three different TAPS criteria. Collaborative studies are needed to investigate the validity and the performance of different TAPS criteria.
Effects of 4‐Br‐A23187 on Bacillus subtilis cells and unilamellar vesicles reveal it to be a potent copper ionophore
Authors: Senges Christoph H. R. , Warmuth Helen L. , Vázquez‐Hernández Melissa , Uzun Huriye Deniz , Sagurna Leonie , Dietze Pascal , Schmidt Claudia , Mücher Brix , Herlitze Stefan , Krämer Ute , Ott Ingo , Günther Pomorski Thomas , Bandow Julia E. 
Published: June 2022

AbstractIonophores are small molecules or peptides that transport metal ions across biological membranes. Their transport capabilities are typically characterized in vitro using vesicles and single ion species. It is difficult to infer from these data which effects ionophores have on living cells in a complex environment (e.g., culture medium), since net ion movement is influenced by many factors including ion composition of the medium, concentration gradients, pH gradient, and protein‐mediated transport processes across the membrane. To gain insights into the antibacterial mechanism of action of the semisynthetic polyether ionophore 4‐Br‐A23187, known to efficiently transport zinc and manganese in vitro, we investigated its effects on the gram‐positive model organism Bacillus subtilis. In addition to monitoring cellular ion concentrations, the physiological impact of treatment was assessed on the proteome level. 4‐Br‐A23187 treatment resulted in an increase in intracellular copper levels, the extent of which depended on the copper concentration of the medium. Effects of copper accumulation mirrored by the proteomic response included oxidative stress, disturbance of proteostasis, metal and sulfur homeostasis. The antibiotic effect of 4‐Br‐A23187 is further aggravated by a decrease in intracellular manganese and magnesium. A liposome model confirmed that 4‐Br‐A23187 acts as copper ionophore in vitro.
Ovarian serous carcinoma in which mediastinal recurrence of the cancer was resected 16 years after surgery: A case report
Authors: Miura Hiroyuki , Miura Jun , Goto Shinichi , Yamamoto Tomoko 
Published: June 2022

AbstractWe report a rare case of ovarian carcinoma in which a mediastinal recurrence was resected 16 years after the initial operation. A 72‐year‐old woman underwent hysterectomy with adnexectomy for stage IIIC ovarian serous carcinoma after neoadjuvant chemotherapy. Six courses of adjuvant chemotherapy were administered. Three years after surgery, left supraclavicular lymph node metastasis occurred, and radiotherapy and two courses of chemotherapy were administered. Six years before presentation, a metastasis at the right cardiophrenic lymph node was resected, and six courses of chemotherapy were administered. During follow‐up, a retrosternal tumour was found. The metastatic lesion in contact with the diaphragm was thought to result from pleuroperitoneal communication, and it increased in size. Although high‐grade serous carcinoma is aggressive, its sensitivity to chemotherapy may suppress early recurrence, contributing to good outcomes, but with late recurrence. Multidisciplinary therapy including surgery is required for improved long‐term prognosis for mediastinal metastasis of ovarian serous carcinoma.
Indurated Erythema of Abdominal Skin: An Unusual Presentation of Metastatic Endometrial Carcinoma—Case Report with Literature Review
Authors: Niebel Dennis , Kranert Paula , Berneburg Mark , Drexler Konstantin , von Eichborn Maria Isabel , Braess Jan , Allgäuer Michael , Karrer Sigrid 
Published: June 2022

Abstract
Carcinoma erysipelatoides (CE) is a rare clinical manifestation of cutaneous metastasis, which mimics inflammatory conditions such as erysipelas. Depending on the site of the originating tumour, unusual manifestations involving different sites of the body may occur. We herein report a case of a 60-year-old female patient with metastatic endometrial carcinoma presenting as CE of the abdominal skin and the inguinal folds. Even though the diagnosis of advanced malignancy had been established before and she was currently receiving chemotherapy (carboplatin and paclitaxel), the clinical appearance closely resembled fungal (candidal intertrigo) and consecutively bacterial (erysipelas) infection, which resulted in treatment with antimycotics and antibiotics at first. Dermatohistopathological examination of skin biopsies revealed a diffuse and nodular infiltrate of pleomorphic atypical tumour cells with strong expression of cytokeratin 7 and PAX8, also detectable within lymphatic vessels. Therapy comprised antiseptic ointments to prevent superinfection, palliative electron beam radiation and supportive care. Since there were no targetable KRAS-, NRAS- and BRAF-gene mutations, systemic therapy was switched to checkpoint inhibition (pembrolizumab) in combination with lenvatinib. The overall prognosis of cutaneous metastasis of endometrial carcinoma is dismal with most patients succumbing to disease within few months. Similarly, our patient died after 3 months due to sepsis in the course of malignant pleural effusion. We aim to highlight the possibility of unusual sites of CE and the risk of respective clinical misdiagnoses.
Catalytic Oxidation of Carbon Monoxide over CeO2 and La2O3 Oxides Supported Nickel Catalysts: The Effect of the Support and NiO Loading
Authors: Benrabaa Rafik , Fares Aissat , Fodil Cherif Nawal , Gouasmia Abir , Yeste Pilar , Cauqui Miguel‐Angel 
Published: June 2022

AbstractCeO2 and La2O3 oxides supported NiO loading (5 and 20 wt%) were synthesized, characterized by ICP‐AES, XRD, IR‐ATR, SEM, B.E.T, H2‐TPR and applied to CO oxidation with and without pretreatment under H2 atmosphere. It was shown that the support has a significant effect on the bulk, surface and reactivity properties. The reduction of nickel to metallic species occurred at higher temperatures in ceria case. 20‐Ni/La sample showed the best catalytic activity without reduction but this behavior mitigates when the sample pretreated under H2 indicating that the presence of different kinds sites responsible of CO oxidation. An opposite reactivity property was obtained in 5‐Ni/La and 20‐Ni/La cases and the interfacial γ‐type NiO interactions decreases with NiO loading which was coincident with CO oxidation activity. The active species in 20‐Ni/La sample is of type metal/support interface≡γ‐NiO/La2O3. In contrast, for 5‐Ni/La and 20‐Ni/Ce catalysts, γ‐NiO active sites incorporated into support is available.
Detection of Acetylcholine in an Enzyme‐Free System Based on a GCE/V2O5 NRs/BPM Modified Sensor
Authors: Musarraf Hussain Mohammad , Asiri Abdullah M. , Hasnat Mohammad A. , Ben Aoun Sami , Rahman Mohammed M. 
Published: June 2022

AbstractIn this approach, vanadium pentoxide nanorods (V2O5NRs) were prepared by utilizing a facile wet‐chemical approach (WCA) in an alkaline phase at low temperatures then applied to detect acetylcholine. Various optical techniques, such as Ultra‐Violet spectroscopy (UV‐Visible), Fourier Transform Infra‐red spectroscopy (FTIR), Powder X‐ray Diffraction (XRD), Field Emission Scanning Emission Microscopy (FESEM), X‐ray Electron Dispersive Spectroscopy (XEDS) and X‐ray Photo‐electron Spectroscopy (XPS) were applied to analyse the V2O5NRs for structural, optical, functional, morphological and elemental analyses. Adjustment of the light weight fabrication of NRs onto Glassy carbon electrode (GCE) exhibited sensitive and selective acetylcholine sensor probe. Based on the stable current‐voltage relationship, analytical sensing parameters like sensitivity, Linear dynamic range (LDR), Limit of detection (LOD), Limit of quantification (LOQ), durability and interference measurement of the fabricated sensor (GCE/V2O5NRs/BPM) for acetylcholine detection were evaluated and reported in this paper. Here, Nafion was used as a binding polymer matrix (BPM) for the fabrication of flat GCE with V2O5NRs. Acetylcholine calibration curve was found to be linear throughout in a broad range of concentration of target acetylcholine analyte. Calibration curve was employed to calculate the sensing parameters such as sensitivity (101.27 nAμM−1cm−2), LOD down to 11.58 pM, LOQ (38.60 pM) and LDR (100 pM∼100 μM) of the developed GCE/V2O5NRs/BPM sensor probe. The use of the facile WCA method for the synthesis of low‐dimensional V2O5NRs is a good strategy for developing an un‐doped nano‐material based sensor for enzyme‐free bio‐molecule recognition and detection via this electrochemical approach. The developed (GCE/V2O5NRs/BPM) sensor probe could be used to selectively detect acetylcholine in real biological samples by electrochemical method with satisfactory outcomes.
Preparation of BiVO4/RGO‐TNT Nanomaterials for Efficient and Recyclable Photocatalysis of Imidacloprid Insecticide
Authors: Piao Mingyue , Sun Yuwei , Wang Yixuan , Teng Honghui 
Published: June 2022

AbstractThe photocatalytic composites based on BiVO4, TiO2 nanotubes (TNT) and reduced graphene oxide (RGO) were synthesized by a one‐step hydrothermal synthesis method. The properties and structures of the samples were characterized by SEM, XRD, UV‐Vis DRS, Raman spectroscopy, photoluminescence spectroscopy and XPS. The effects of RGO‐TNT loading, pH, and dosage of catalysts on degradation efficiency were tested. The best removal results were occured on the condition that loading amount of RGO‐TNT was 10 %, solution pH 10, and catalyst dosage was 1.4 g L−1. The obtained ternary composite with 10 wt% RGO‐TNT exhibited a significant enhancement in photocatalytic efficiency due to the lower band gap with enhanced light absorption and a suppression in the recombination rates of the photogenerated charge carriers, and about 73 % of imidacloprid was degraded within 30 min under UV irradiation. Furthermore, BiVO4/RGO‐TNT‐10 can be reused for 6 times without obvious catalysis loss. Trapping experiments showed that hydroxyl radicals were the main active species in the imidacloprid photocatalytic degradation, and a possible photocatalytic mechanism was proposed based on the results of trapping experiments.
Evolving Trends for C−C Bond Formation Using Functionalized Covalent Organic Frameworks as Heterogeneous Catalysts
Authors: Pasricha Sharda , Chaudhary Ankita , Srivastava Abhay 
Published: June 2022

AbstractCovalent organic frameworks (COFs), also called “Organic Zeolites,” are crystalline porous organic polymers with robust and pre‐designable architecture and high crystallinity. They can be structurally controlled and functionally managed, due to the availability of diverse organic functionalities, covalent linkages and topologies. The current review briefly outlines their design strategies and comprehensively discusses their applications in the carbon‐carbon bond formation reactions. The reactivity of COF‐based catalysts with their homogeneous counterparts, catalyst stability, role of matrix, tailored organocatalysts and substituent effect on the reaction parameters, chemo‐/stereo‐/regioselectivity, shape/size selectivity are also discussed. Finally, the challenges and future prospects of functionalized COF‐based catalysts are discussed. These discussions will provide a better understanding of the role of COF‐based catalysts in the C−C bond formation and will also open doors to the design and synthesis of more robust, sustainable and benign catalytic systems, which might play a key role in organic synthesis and catalysis.
Quinolone‐Rhodanine Hybrid Compounds: Synthesis and Biological Evaluation as Anti‐Bacterial Agents
Authors: Cebeci Yıldız Uygun , Karaoğlu Şengül Alpay 
Published: June 2022

AbstractAs potential antimicrobial agents, 4‐fluoroaniline and diethyl (ethoxymethylene)malonate were used to efficiently synthesize a new quinolone (3‐9) series. The 1HNMR and 13C NMR, IR, mass spectrometry, and elemental analysis of all compounds were used to identify them. The final compounds 3–9 were in vitro screened for antimicrobial activity against gram negative‐gram positive Escherichia coli, Yersinia pseudotuberculosis, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus, Mycobacterium smegmatis and fungal strains Candida albicans, Saccharomyces cerevisiae. The best antimicrobial activity was demonstrated by compounds 9a and 9b. Antimicrobial resistance and microbial infection could benefit from quinolone derivatives′ ability to inhibit the growth of microorganisms, according to this study.
NCI Study of the Influence of Steric Hindrance on the Conformational Isomers of Propane, Butane, and Ethane Derivatives
Authors: Briceño‐Vargas Flor M. , Mirón‐López Gumersindo , Quijano‐Quiñones Ramiro F. 
Published: June 2022

AbstractThe role of the steric clash in the rotational energy barrier in CX3CX3 (X=H, CH3, F), propane, and butane compounds was studied using the NCI method and QTAIM approach. We found that the values of the repulsive density integral of NCI agrees with the traditional chemical steric model, as it increases with the size of the substituent. However, not in every case studied here, was the steric clash identified as the origin of the energy barrier. In the ethane case we note the absence of repulsive and attractive NCI across the full spectrum of the dihedral angles studied, whereas only in the propane and butane cases are the results consistent with the classical picture of the steric clash being the origin of the energy barrier. The energy profile for 2,2,3,3‐tetramethylbutane shows two energy barriers of 8.7 kcal/mol and 0.96 kcal/mol, their origin was analysed in terms of the alkyl‐alkyl interactions.
Metal Free Approach towards the Synthesis of Structurally Diverse 1, 2‐Dihydronaphthalene Scaffolds and Theoretical Investigation
Authors: Pramanik Amit , Ghatak Avishek , Khanra Somnath , Das Debasis , Rakshit Tatini , Bhar Sanjay 
Published: June 2022

AbstractBiologically potent and synthetically significant 1,2‐dihydronaphthalene derivatives have gained considerable attention due to their wide applications in industrial as well as in medicinal fields also. A mild and efficient metal‐free protocol via the rearrangement of cyclopropylcarbinols has been reported to construct these 1,2‐dihydronaphthalene skeletons utilizing cyclopropane ring as the scaffold. We obtained conjugated dienes and, in some cases, homoallylic chlorides as major products in good to excellent yields. They have no literature precedence till date. The fate of this rearrangement depends on the substituent patterns of the cyclopropane bearing aryl moiety. Besides the synthetic studies, to get deep insight into the electronic transitions, time dependent DFT studies have also been performed.