bluuebunny/crossref_metadata_2025_split huggingface dataset:
Halide Solid‐State Electrolytes: Stability and Application for High Voltage All‐Solid‐State Li Batteries
Authors: Nikodimos Yosef , Su Wei‐Nien , Hwang Bing Joe 
Published: November 2022

AbstractOver the past few years, halide solid‐state electrolytes (HSSEs) have attracted the attention of researchers, and many reports about HSSEs have been published. Their wide electrochemical window (ECW) and a quite good compatibility with the popular oxide cathode materials make them attractive for practical applications. As a result, HSSEs are exciting candidates for the future generation of all‐solid‐state Li batteries (ASSLBs). In recent years, noticeable efforts have been made to develop novel HSSEs and utilize them in ASSLBs. Herein, a comprehensive update on the progress of HSSEs development and their application in ASSLBs is provided. First, a brief summary of the conductivity of HSSEs and potential synthesis approaches is provided. Next, the moisture and phase stabilities of HSSEs are reviewed separately, and the techniques proposed in the recently published reports to achieve sufficient stabilities are summarized. In addition, the electrochemical stabilities of HSSEs with Li metal anode and oxide cathode materials, from experimental and theoretical points of view, are provided in parallel. Furthermore, the application and progress of HSSEs in high‐voltage ASSLBs are discussed. Finally, new research directions are suggested for the development of scalable HSSEs‐based ASSLBs.
Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease
Authors: Castranio Emilie L. , Hasel Philip , Haure‐Mirande Jean‐Vianney , Ramirez Jimenez Angie V. , Hamilton B. Wade , Kim Rachel D. , Glabe Charles G. , Wang Minghui , Zhang Bin , Gandy Sam , Liddelow Shane A. , Ehrlich Michelle E. 
Published: November 2022

AbstractIntroductionThe inositol polyphosphate‐5‐phosphatase D (INPP5D) gene encodes a dual‐specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins. Single nucleotide polymorphisms in INPP5D impact risk for developing late onset sporadic Alzheimer's disease (LOAD).MethodsTo assess the consequences of inducible Inpp5d knockdown in microglia of APPKM670/671NL/PSEN1Δexon9 (PSAPP) mice, we injected 3‐month‐old Inpp5dfl/fl/Cx3cr1CreER/+ and PSAPP/Inpp5dfl/fl/Cx3cr1CreER/+ mice with either tamoxifen (TAM) or corn oil (CO) to induce recombination.ResultsAt age 6 months, we found that the percent area of 6E10+ deposits and plaque‐associated microglia in Inpp5d knockdown mice were increased compared to controls. Spatial transcriptomics identified a plaque‐specific expression profile that was extensively altered by Inpp5d knockdown.DiscussionThese results demonstrate that conditional Inpp5d downregulation in the PSAPP mouse increases plaque burden and recruitment of microglia to plaques. Spatial transcriptomics highlighted an extended gene expression signature associated with plaques and identified CST7 (cystatin F) as a novel marker of plaques.Highlights
Inpp5d knockdown increases plaque burden and plaque‐associated microglia number.
Spatial transcriptomics identifies an expanded plaque‐specific gene expression profile.
Plaque‐induced gene expression is altered by Inpp5d knockdown in microglia.
Our plaque‐associated gene signature overlaps with human Alzheimer's disease gene networks.
Integrating spatial and legacy data to understand archaeological sites in their landscape. A case study from Unguja Ukuu, Zanzibar
Authors: Fitton Tom , Sulas Federica , Lisowski Mik , Alexander Michelle , Juma Abdurahman , Wynne‐Jones Stephanie 
Published: November 2022

AbstractSpatial analysis is paramount for understanding, monitoring, and conserving ancient settlements and cultural landscapes. Advancing remote sensing and prospection techniques are expanding the methodological frame of archaeological settlement analysis by enabling remote, landscape‐scale approaches to mapping and investigation. Whilst particularly effective in arid lands and areas with sparse or open ground cover, such as vegetation and buildings, these approaches remain peripheral in tropical environments because of technical and contextual challenges. In tropical Eastern Africa, for example, scales, resolution and visibility are often compromised by thick vegetation cover, inadequate access to, if not lack of, imagery resources and technologies, and the availability of comparative archaeological data for interpretation. This paper presents the initial results of spatial analysis, using historic landscape characterisation, remote sensing, published and legacy data, and a pilot ground survey to examine the earliest settlement of Zanzibar, Unguja Ukuu. Comparing multiple strands of evidence in a Geographic Information System (GIS), we use each as a test on the others to draw out the strengths and weaknesses of each technique in the context of tropical and coastal Eastern Africa. Drone photogrammetry, geophysical prospection, and ground survey were compared with legacy remote sensing resources and the results of a coring survey conducted across the site during the 1990s into a GIS platform to produce multi‐phase hypothetical maps of the archaeological site in the context of its potential resource landscape. These were then tested against the results of recent excavations. The discussion highlights the challenges and potential of combining these techniques in the context of Eastern Africa and provides some suggested methods for doing so. We show that remote sensing techniques give an insight into current landscapes but are less useful in understanding or modelling how sites would have fitted into their surroundings in the past, when conditions were potentially very different.
Assessing the demand side management potential in biofuel production; A theoretical study for biodiesel, bioethanol, and biomethane in Germany
Authors: Röder Lilli Sophia , Gröngröft Arne , Grünewald Marcus , Riese Julia 
Published: November 2022

AbstractMinimizing the emissions produced during the processing of biofuel, one aim is to reduce or completely replace the amount of the required fossil fuels used for internal process energy. For the transition of process energy from fossil to renewable energy sources, such as solar and wind, the energy demand of biomass processing must be adjustable to the fluctuating electricity supply. The flexible adjustment of a system's power demand to follow the current power generation is commonly referred to as demand side management (DSM). This contribution shows the results of a study on the implementation of DSM in biofuel biorefineries. By identifying reference concepts that could represent biofuel production plants, the specific mass and energy consumption for the individual process steps in these reference concepts was analyzed through a literature study. The annual throughput and energy consumption of process steps in biofuel production could then be calculated, enabling the identification of the most energy‐consuming process steps. Subsequently, possible flexible operating load ranges of the respective process steps in biofuel production were identified. These findings allowed an assessment of the potential for different process units of biorefinery systems concerning the quantitative adaptability of the electricity load – the theoretical DSM potential. An approximate theoretical DSM potential of 146 MW has been identified for biofuel production in Germany. This cumulated theoretical DSM potential in biofuel production was compared to that of other industrial processes, demonstrating the magnitude and importance of the implementation of DSM in biofuel production. © 2022 The Authors. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd.
BTB domains: A structural view of evolution, multimerization, and protein–protein interactions
Authors: Bonchuk Artem , Balagurov Konstantin , Georgiev Pavel 
Published: November 2022

AbstractBroad‐complex, Tramtrack, and Bric‐à‐brac/poxvirus and zinc finger (BTB/POZ) is a conserved domain found in many eukaryotic proteins with diverse cellular functions. Recent studies revealed its importance in multiple developmental processes as well as in the onset and progression of oncological diseases. Most BTB domains can form multimers and selectively interact with non‐BTB proteins. Structural studies of BTB domains delineated the presence of different interfaces involved in various interactions mediated by BTBs and provided a basis for the specific inhibition of distinct protein‐interaction interfaces. BTB domains originated early in eukaryotic evolution and progressively adapted their structural elements to perform distinct functions. In this review, we summarize and discuss the structural principles of protein‐protein interactions mediated by BTB domains based on the recently published structural data and advances in protein modeling. We propose an update to the structure‐based classification of BTB domain families and discuss their evolutionary interconnections.
Board gender diversity and corporate carbon commitment: Does industry matter?
Authors: Lemma Tesfaye T. , Tavakolifar Mohammad , Mihret Dessalegn , Samkin Grant 
Published: November 2022

AbstractThe study examines whether board gender diversity is associated with corporate carbon commitment, and if so, whether the association varies between firms operating in the extractive and non‐extractive industries. Based on insights drawn from gender socialization, resource dependence, and critical mass theories, we develop models that link board gender diversity with corporate carbon commitment. Analyzing data obtained from Standard and Poor's 1500 firms, for the period 2015 to 2019, we find that higher representation of women on a firm's board is positively associated with the firm's carbon commitment and that the association is stronger for firms in the extractive industries. Furthermore, a nominal appointment of women to a firm's board reduces the likelihood of the firm's carbon commitment being at a given or higher level, while the appointment of a “critical mass” of women to the board increases the firm's inclination toward higher carbon commitment. Our findings suggest that regulatory and policymaking agencies could exploit legislative and policy initiatives that would promote board gender diversity to encourage corporates, especially those operating in the extractive industries, to commit to the climate change cause.
Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells
Authors: Çevik Dicle , Erdogan Suat , Serttas Riza , Kan Yüksel , Kırmızıbekmez Hasan 
Published: November 2022

AbstractCytotoxic activity‐guided fractionation studies on Glycyrrhiza echinata roots led to the isolation of eight compounds (1–8). Chemical structures of the isolates were identified by NMR and MS analysis. Among the tested molecules, retrochalcones namely echinatin (3) (IC50=23.45–41.83 μM), licochalcone B (4) (IC50=36.04–39.53 μM) and tetrahydroxylmethoxychalcone (5) (IC50=7.09–80.81 μM) were the most active ones against PC3, MCF7 and HepG2 cells. Moreover, 5 exhibited selectivity on prostate cancer cells (SI: 5.19). Hoechst staining and Annexin V/PI binding assays as well as cell cycle analysis on the compounds 3 (23 μM) and 5 (5 and 7 μM) demonstrated that these retrochalcones induced apoptosis and significantly suppressed cell cycle in G1 and G2/M phases. Furthermore, 3 and 5 showed antimigratory effects on PC3 cells by wound healing assay. The results indicated that tested retrochalcones most particularly 5 could be potential anticancer drug candidates that prevent proliferation and migration of cancer cells.
Optimization framework for patient‐specific modeling under uncertainty
Authors: Mineroff Joshua , Pokuri Balaji Sesha Sarath , Ganapathysubramanian Baskar , Krishnamurthy Adarsh 
Published: November 2022

AbstractEstimating a patient‐specific computational model's parameters relies on data that is often unreliable and ill‐suited for a deterministic approach. We develop an optimization‐based uncertainty quantification framework for probabilistic model tuning that discovers model inputs distributions that generate target output distributions. Probabilistic sampling is performed using a surrogate model for computational efficiency, and a general distribution parameterization is used to describe each input. The approach is tested on seven patient‐specific modeling examples using CircAdapt, a cardiovascular circulatory model. Six examples are synthetic, aiming to match the output distributions generated using known reference input data distributions, while the seventh example uses real‐world patient data for the output distributions. Our results demonstrate the accurate reproduction of the target output distributions, with a correct recreation of the reference inputs for the six synthetic examples. Our proposed approach is suitable for determining the parameter distributions of patient‐specific models with uncertain data and can be used to gain insights into the sensitivity of the model parameters to the measured data.
UBTF‐internal tandem duplication as a novel poor prognostic factor in pediatric acute myeloid leukemia
Authors: Kaburagi Taeko , Shiba Norio , Yamato Genki , Yoshida Kenichi , Tabuchi Ken , Ohki Kentaro , Ishikita Etsuko , Hara Yusuke , Shiraishi Yuichi , Kawasaki Hirohide , Sotomatsu Manabu , Takizawa Takumi , Taki Tomohiko , Kiyokawa Nobutaka , Tomizawa Daisuke , Horibe Keizo , Miyano Satoru , Taga Takashi , Adachi Souichi , Ogawa Seishi , Hayashi Yasuhide 
Published: November 2022

AbstractThe prognosis of pediatric acute myeloid leukemia (AML) has improved via stratification therapy. However, relapse or death occurs in 30%–40% of cases. Novel genetic factors for pediatric AML need to be elucidated to improve prognosis. We detected recurrent internal tandem duplication in upstream binding transcription factor (UBTF‐ITD) in 1.2% (6/503) of Japanese pediatric patients with de novo AML. No UBTF‐ITD was detected in 175 adult patients with AML or in 65 cell lines that included 15 AML, 39 acute lymphoblastic leukemia, five chronic myeloid leukemia, and six neuroblastoma cell lines. All UBTF‐ITDs were found in exon 13 and shared a duplicated region. UBTF‐ITD was more frequently detected in patients with trisomy 8, FLT3‐ITD, WT1 mutation, and/or high PRDM16 expression (trisomy 8, 3/6; FLT3‐ITD, 5/6; WT1 mutation, 2/6; and high PRDM16 expression, 6/6). Gene expression patterns of patients with UBTF‐ITD were similar to those of patients with NUP98::NSD1 or FUS::ERG. Survival analysis of the AML‐05 cohort revealed that patients with UBTF‐ITD had worse outcomes than those without UBTF‐ITD (3‐year event‐free survival, 20% vs. 55%; 3‐year overall survival, 40% vs. 74%). Moreover, among the 27 patients with trisomy 8, all three patients with UBTF ‐ITD had a poor prognosis resulting in early events (relapse or non‐complete remission) within 1 year. Our findings suggest that UBTF‐ITD may be a novel and significant prognostic factor for pediatric patients with AML.
Promoting social inclusion among asylum seekers and refugees living in the south east region of Melbourne, Australia, through volunteering
Authors: Russo Alana , Koch Rob , McBride Jacquie 
Published: November 2022

AbstractIssue addressedThis article describes the Refugee Health Volunteer Program; a Monash Health initiative that aimed to promote social inclusion among asylum seekers and refugees within the south‐eastern region of Melbourne, Australia. This article also presents the evaluation findings of this strategy.MethodsThis mixed‐methods evaluation aimed to determine the impact of the Volunteer Program at both an individual and organisational level. Volunteers completed a survey (n = 39) and participated in interviews (n = 14), and staff working alongside volunteers at Monash Health Community completed a survey (n = 82).ResultsVolunteers attributed a range personal benefits to their involvement in the Refugee Health Volunteer Program; reporting improvements across all survey domains, including “Personal development,” “Skill development,” “Health and wellbeing,” “Sense of trust and inclusion,” “Social development.” Further, within the interviews participants discussed that through volunteering they had made friends, developed new skills and felt their emotional wellbeing had improved. Staff members (n = 82) working at Monash Health Community also reflected positively on the program, reporting that volunteers increased organisational capacity and enhanced their personal understanding of asylum seeker and refugee issues.ConclusionsThis program has successfully responded to an emerging need within the local asylum seeker and refugee community. Applying a social determinants framework acknowledges the fundamental impact of social connectivity on wellbeing.So what?Many of the factors that adversely impact the wellbeing of asylum seekers and refugees sit beyond both individual and organisational control. However, this article defines an effective volunteering model that fosters social inclusion and promotes emotional wellbeing among humanitarian arrivals in Australia, within the confines of the existing context.
Voluntary private health insurance demand by Portuguese seniors before the COVID‐19 pandemic
Authors: Tavares Aida Isabel 
Published: November 2022

AbstractAimsThe Portuguese health system is mainly described as a National Health Service (NHS), but it also has some Bismarckian features. On top of these two layers of health insurance coverage, there is a market for voluntary private health insurance (VPHI). Usually, seniors are not eligible for this type of health insurance and this may serve as a complement or supplement to the NHS. The purpose of this work is to identify the main factors associated with holding a VPHI policy among seniors before the COVID‐19 pandemic.Material and MethodsWe use data collected by the National Health Survey of 2019/20 and estimate a multivariate logistic regression.ResultsThe main findings show that VPHI may be bought by seniors as a facilitator to access health care, either specialised or dental care. While oral health is not covered by the NHS, specialist care is only available after referral by a gatekeeper and requires a long waiting time to be scheduled. Results show that people who had an appointment with a dentist or a specialist in the last 12 months are more likely to have a VPHI policy. Additionally, it was found that people benefiting from occupation‐based insurance schemes are less likely to buy private health insurance.ConclusionThe current Portuguese health system organization based on different layers of health protection raises some issues concerning equity to health care access by seniors.
Coaching during a crisis: Organizational coaches' praxis adaptation during the initial stages of the Covid‐19 pandemic
Authors: Terblanche Nicky H. D. 
Published: November 2022

AbstractThe chaotic initial stages of the Covid‐19 pandemic severely challenged organizations. Economies shut down and millions of people were confined to their homes. Human resource practitioners turned to organizational coaching, a trusted human resource development intervention for help, however, to remain relevant during the crisis coaches had to adapt their praxis. The working alliance describes the mutual bond, goal, and task alignment between coach and client and is an indication of coaching efficacy. This study investigates to what extent organizational coaches' praxis adaptation at the start of the pandemic maintained a working alliance that still served the human resource development (HRD) paradigms of learning, performance, and meaningful work. Interviews with 26 organizational coaches from USA, UK, Australia, and South Africa recorded during the first general lockdown (April 2020) were inductively analyzed using thematic analysis and deductively interpreted through the working alliance theory and desired HRD outcome paradigms. Findings reveal seven organizational coaching praxis adaptations judged to support all three working alliance components, with “task” and “goal” more prominent than “bond,” suggesting a pragmatist preference reminiscent of crisis management. Praxis adaptation also seems to promote all three HRD paradigms of learning, performance, and meaningful work on individual and/or organizational levels. This study strengthens the already well‐established link between HRD and coaching by positing that coaching is a dynamic, pragmatic, self‐adaptive intervention that supports HRD during a crisis. Understanding coaches' praxis adaptation during the volatile initial stages of a crisis is important for HRD theory and practice given HRDs increasing reliance on coaching.
Effects of bicyclol on hepatic sinusoidal obstruction syndrome induced by Gynura segetum
Authors: Yao Jianzuo , Wu Jingyi , Jia Shu , Shao Jingping , Zhang Xie , Xu Zeping , Zhang Hui , Li Hong , Yao Xiaomin 
Published: November 2022

AbstractBackgroundThe intake of Gynura segetum, a traditional Chinese medicine, may be induce hepatic sinusoidal obstruction syndrome (HSOS). It has a high mortality rate based on the severity of the disease and the absence of therapeutic effectiveness. Therefore, the current study was designed to investigate the effects of bicyclol on HSOS induced by Gynura segetum and the potential molecular mechanisms.MethodsGynura segetum (30 g/kg) was administered for 4 weeks in the model group, while the bicyclol pretreatment group received bicyclol (200 mg/kg) administration. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), cholesterol (CHO), triglyceride (TG), and liver histological assays were detected to assess HSOS. The gene expressions of cytochrome P450 (CYP450) isozymes were quantified by real‐time PCR. Moreover, hepatocellular apoptosis was detected using the terminal deoxynucleotidyl transferase dUTP nick‐end labeling (TUNEL) assay, then apoptosis and autophagy‐related markers were determined using Western blot.ResultsAs a result, bicyclol pretreatment is notably protected against Gynura segetum‐induced HSOS, as observed by reducing serum ALT levels, inhibiting the reduction in CHO and TG levels, and alleviating the histopathological changes. Bicyclol pretreatment inhibited the changes in mRNA levels of CYP450 isozymes (including the increase in CYP2a5 and decrease in CYP2b10, 2c29, 2c37, 3a11, and 7b1). In addition, the upregulation of Bcl‐2 and the downregulation of LC3‐II/LC3‐I proteins expression in HSOS were inhibited with bicyclol pretreatment.ConclusionBicyclol exerted a protective effect against HSOS induced by Gynura segetum, which could be attributed to the regulated expressions of CYP450 isozymes and alleviated the downregulation of autophagy.