bluuebunny/crossref_metadata_2025_split huggingface dataset:
Information and Communication Technologies (ICTs) enabling integrated primary care for complex patients: a protocol for a scoping review
Authors: Tahsin Farah , Armas Alana , Kirakalaprathapan Apery , Cunningham Heather , Kadu Mudathira , Sritharan Jasvinei , Steele Gray Carolyn 
Published: September 2022

Abstract
Introduction
An increasing number of individuals are living with multiple chronic conditions, often combined with psychosocial complexities. For these patients with complex conditions, an integrated primary care model that provides care coordination and a team-based approach can help manage their multiple needs. Information and communication technologies (ICTs) are recognized as a critical enabler of integrated primary care. A better understanding of the use of ICTs in an integrated care setting and how ICTs are being leveraged would be beneficial to identify knowledge gaps and could lead to successful implementation for ICT-based interventions.

Objective
This study will systematically scope the literature on the topic of ICT-enabled integrated healthcare delivery models for patients with complex care needs to identify which technologies have been used in integrated primary care settings.

Method
This study protocol outlines a scoping review of the peer-reviewed literature, using Arksey and O’Malley’s (enhanced by Levac et al.) scoping review methodology. Peer-reviewed literature will be identified using a multi-database search strategy. The results of the search will be screened, abstracted, and charted in duplicate by six research team members.

Discussion
The key findings of the study will be thematically analyzed to describe the implemented ICTs aimed for complex patients within the integrated primary care model. The finding will highlight what types of ICTs are being put in place to support these models, and how these ICTs are enabling care integration. This review will be the first step to formally identify how ICT is used to support integrated primary health care models. The results will be disseminated through peer-reviewed publications, conference presentations, and special interest groups.
Herd behaviour in foreign exchange market
Authors: Yasir Anam , Safdar Umar , Javaid Yasir 
Published: September 2022

AbstractThis study examines the presence of herding behaviour in the forex market of Pakistan. By analysing the daily returns of the top six traded currencies from January 2015 to December 2019, the current research explores the behaviour of investors towards investment in currencies. Data is analysed using the model proposed by Chang et al. (2000). Results of estimation techniques provide evidence of herd behaviour among investors. Findings suggest that investors do not rely on their own decision-making; rather they follow the patterns of others. Furthermore, this imitating behaviour in same in up and down market events. Findings of this study provide significant insights for future researchers about decision-making of investors in forex market.
Lessons Learnt From Pilot Cervical Cancer Screening and Treatment Programmes Integrated to Routine Primary Health Care Services in Benin, Cote d'Ivoire, and Senegal
Authors: Selmouni Farida , Sauvaget Catherine , Dangbemey Djima Patrice , Kpebo Djoukou Denise Olga , Dieng Ndeye Mbombe , Lucas Eric , Chami Khazraji Youssef , Bennani Maria , Bekkali Rachid , Basu Partha 
Published: September 2022

PURPOSE The project aimed to implement pilot screening and treatment services for cervical cancer integrated with existing primary health centers (PHCs) in Benin, Cote d'Ivoire, and Senegal and evaluate these services using implementation research outcomes such as reach, effectiveness, adoption, and acceptability. MATERIALS AND METHODS The Ministry of Health in each country took the lead in setting up a stakeholder's group that designed a protocol tailored to the local context. The target age was 25-49 years in Benin and Cote d'Ivoire and 30-49 years in Senegal. Visual inspection with acetic acid (VIA) was the screening test, and thermal ablation (TA) was the ablative treatment of choice in all. The Ministry in each country identified 4-5 PHCs to set up screening and ablation services and one higher-level center for colposcopy referral. After a master-trainer led training program, nurses, midwives, or general practitioners screened opportunistically the eligible women attending the clinics. The VIA-positive women eligible for ablation were offered immediate treatment. RESULTS Between May 2018 and January 2021, 16,530 women were screened opportunistically. VIA positivity was 8.1% with huge variability within and between countries. Sixty-one percent of all VIA-positive cases were eligible for immediate TA, and 88% of them accepted same-day treatment. Compliance to TA at PHCs was 99%. Majority of women treated with TA complained of minor side effects. Significant dropouts occurred as the women were referred to colposcopy clinics. CONCLUSION Opportunistic screening provided as part of routine PHC service can screen many women and treat a significant proportion of screen-positive women with TA with minimal side effects. Primary concerns are the hard-to-reach women who remain out of opportunistic screening coverage and noncompliance of the screen-positive women referred to higher-level centers.
A Phase III Study of Pafolacianine Injection (OTL38) for Intraoperative Imaging of Folate Receptor–Positive Ovarian Cancer (Study 006)
Authors: Tanyi Janos L. , Randall Leslie M. , Chambers Setsuko K. , Butler Kristina A. , Winer Ira S. , Langstraat Carrie L. , Han Ernest S. , Vahrmeijer Alexander L. , Chon Hye Sook , Morgan Mark A. , Powell Matthew A. , Tseng Jill H. , Lopez Alexis S. , Wenham Robert M. 
Published: September 2022

PURPOSE The adjunctive use of intraoperative molecular imaging (IMI) is gaining acceptance as a potential means to improve outcomes for surgical resection of targetable tumors. This confirmatory study examined the use of pafolacianine for real-time detection of folate receptor–positive ovarian cancer. METHODS This phase III, open-label, 11-center study included subjects with known or suspected ovarian cancer, scheduled to undergo cytoreductive surgery. The objectives were to confirm safety and efficacy of pafolacianine (0.025 mg/kg IV), given ≥ 1 hour before intraoperative near-infrared imaging to detect macroscopic lesions not detected by palpation and normal white light. RESULTS From March 2018 through April 2020, 150 patients received a single infusion of pafolacianine (safety analysis set); 109 patients with folate receptor–positive ovarian cancer comprised the full analysis set for efficacy. In 33.0% of patients (95% CI, 24.3 to 42.7; P < .001), pafolacianine with near-infrared imaging identified additional cancer on tissue not planned for resection and not detected by white light assessment and palpation, exceeding the prespecified threshold of 10%. Among patients who underwent interval debulking surgery, the rate was 39.7% (95% CI, 27.0 to 53.4; P < .001). The sensitivity to detect ovarian cancer was 83%, and the patient false-positive rate was 24.8%. Investigators reported achieving complete R0 resection in 62.4% (68 of 109) of patients. Drug-related adverse events were reported by 30% of patients (45 of 150) and most commonly included nausea, vomiting, and abdominal pain. No drug-related serious adverse events or deaths were reported. CONCLUSION This phase III study of pafolacianine met its primary efficacy end point, identifying additional cancers not otherwise identified or planned for resection. Pafolacianine may offer an important real-time adjunct to current surgical approaches for ovarian cancer.
Effects of a 6-wk Sprint Interval Training Protocol at Different Altitudes on Circulating Extracellular Vesicles
Authors: WARNIER GEOFFREY , DE GROOTE ESTELLE , DELCORTE OPHÉLIE , NICOLAS MARTINEZ DANIEL , NEDERVEEN JOSHUA P. , NILSSON MATS I. , FRANCAUX MARC , PIERREUX CHRISTOPHE E. , DELDICQUE LOUISE 
Published: September 2022

ABSTRACT

Purpose
This study aimed to investigate the modulation of circulating exosome-like extracellular vesicles (ELVs) after 6 wk of sprint interval training (SIT) at sea level and at 2000, 3000, and 4000 m.

Methods
Thirty trained endurance male athletes (18–35 yr) participated in a 6-wk SIT program (30-s all-out sprint, 4-min 30-s recovery; 4–9 repetitions, 2 sessions per week) at sea level (n = 8), 2000 m (fraction of inspired oxygen (Fio
2) 0.167, n = 8), 3000 m (Fio
2 0.145, n = 7), or 4000 m (Fio
2 0.13, n = 7). Venous blood samples were taken before and after the training period. Plasma ELVs were isolated by size exclusion chromatography, counted by nanoparticle tracking analysis, and characterized according to international standards. Candidate ELV microRNAs (miRNAs) were quantified by real-time polymerase chain reaction.

Results
When the three hypoxic groups were analyzed separately, only very minor differences could be detected in the levels of circulating particles, ELV markers, or miRNA. However, the levels of circulating particles increased (+262%) after training when the three hypoxic groups were pooled, and tended to increase at sea level (+65%), with no difference between these two groups. A trend to an increase was observed for the two ELV markers, TSG101 (+65%) and HSP60 (+441%), at sea level, but not in hypoxia. Training also seemed to decrease the abundance of miR-23a-3p and to increase the abundance of miR-21-5p in hypoxia but not at sea level.

Conclusions
A 6-wk SIT program tended to increase the basal levels of circulating ELVs when performed at sea level but not in hypoxia. In contrast, ELV miRNA cargo seemed to be modulated in hypoxic conditions only. Further research should explore the potential differences in the origin of ELVs between normoxic and local and systemic hypoxic conditions.
Correlated MR spectroscopic imaging of breast cancer to investigate metabolites and lipids: acceleration and compressed sensing reconstruction
Authors: Joy Ajin , Saucedo Andres , Joines Melissa , Lee-Felker Stephanie , Kumar Sumit , Sarma Manoj K , Sayre James , DiNome Maggie , Thomas M Albert 
Published: September 2022

Objectives:
The main objective of this work was to detect novel biomarkers in breast cancer by spreading the MR spectra over two dimensions in multiple spatial locations using an accelerated 5D EP-COSI technology.

Methods:
The 5D EP-COSI data were non-uniformly undersampled with an acceleration factor of 8 and reconstructed using group sparsity-based compressed sensing reconstruction. Different metabolite and lipid ratios were then quantified and statistically analyzed for significance. Linear discriminant models based on the quantified metabolite and lipid ratios were generated. Spectroscopic images of the quantified metabolite and lipid ratios were also reconstructed.

Results:
The 2D COSY spectra generated using the 5D EP-COSI technique showed differences among healthy, benign, and malignant tissues in terms of their mean values of metabolite and lipid ratios, especially the ratios of potential novel biomarkers based on unsaturated fatty acids, myo-inositol, and glycine. It is further shown the potential of choline and unsaturated lipid ratio maps, generated from the quantified COSY signals across multiple locations in the breast, to serve as complementary markers of malignancy that can be added to the multiparametric MR protocol. Discriminant models using metabolite and lipid ratios were found to be statistically significant for classifying benign and malignant tumor from healthy tissues.

Conclusions:
Accelerated 5D EP-COSI technique demonstrates the potential to detect novel biomarkers such as glycine, myo-inositol, and unsaturated fatty acids in addition to commonly reported choline in breast cancer, and facilitates metabolite and lipid ratio maps which have the potential to play a significant role in breast cancer detection.

Advances in knowledge:
This study presents the first evaluation of a multidimensional MR spectroscopic imaging technique for the detection of potentially novel biomarkers based on glycine, myo-inositol, and unsaturated fatty acids, in addition to commonly reported choline. Spatial mapping of choline and unsaturated fatty acid ratios with respect to water in malignant and benign breast masses are also shown. These metabolic characteristics may serve as additional biomarkers for improving the diagnostic and therapeutic evaluation of breast cancer.
In silico comparison between the mutated and wild-type androgen receptors and their influence on the selection of optimum androgenic receptor blockers for the treatment of prostate cancer
Authors: Akeel Al-Hussaniy Hany , S. Al-tameemi Zahraa , AL-Zobaidy Mohammed J. 
Published: September 2022

Background: Prostate cancer is a disease that occurs in men aged more than 50 years. In Iraq, 8.89 men per 100,000 population suffer from prostate cancer, with the incidence being 14,016 cases and mortality being 6,367 cases. Despite advances in treatment against prostate cancer, it can become resistant to drugs. Therefore, the aim of current study was to search and identify binding sites for the repositioning of drugs by computational methods (docking). Methods: Based on the protein structure of the wild androgen receptor, the analysis parameters (22x22x22 on the X, Y, and Z axes) were established. Results: The interactions of the natural ligands with androgen receptor were 10.0 (testosterone) and 10.8 (dihydrotestosterone) while mutated androgen receptor (T877A) had a low affinity with testosterone and dihydrotestosterone (-5.3 and -6.7, respectively). In the interactions of both receptors with the reported inhibitors (antagonists), a decrease with Bicalutamide (-8.3 and -4.3, respectively) and an increase in affinity with Flutamide and Nilutamide (-7.7 and 8.6, wild AR; -8.7 and -9.3 AR T877A) were observed. As for Enzalutamide and Apalutamide (second-generation antagonists), the change was minimal between wild androgen receptor and T877A (-7.6 and -7.7; -7.3 and -7.3, respectively). The change in the affinity of the ligands with androgen receptor and androgen receptor T877A shows how a mutation alters the bonds between these molecules. Conclusion: The identification of key sites and potent inhibitors against abnormal androgen receptor functions will enrich prostate cancer treatments.
Study of the protective effects of cyanocobalamin on methotrexate induced nephrotoxicity in rats
Authors: Abdulwahhab Rana Q. , Ali Alabdali Samara Muwafaq 
Published: September 2022

Background: Methotrexate (MTX) is a chemotherapeutic drug, used mainly in many cancerous stages, inflammatory and auto-immune diseases, but its use has been limited by its nephrotoxicity. Cyanocobalamin is a water-soluble vitamin possessing nephro-protective properties. The aim of this study was to investigate the effect of cyanocobalamin on the nephrotoxicity of methotrexate. Methods: In the study 42 albino adult female rats were used, divided into six groups each containing seven rats (n=7). 1st group: Control group (Negative control), 7 rats were injected intraperitoneally with 0.5ml/kg/day NS. Second group: 7 rats were injected intraperitoneally with a single dose of methotrexate (20 mg/kg) for 4 days. Third Group: 7 rats were given intraperitoneally cyanocobalamin at a dose (1.5 mg/kg/day) for two weeks, fourth, fifth, sixth group: 7 rats from each group were injected intraperitoneally with different concentrations of cyanocobalamin (0.5, 1, 1.5 mg/kg /day), respectively, for two weeks and MTX (20 mg/kg), which was injected only on day 11. On day 15, rats from all groups were euthanized, and blood samples were taken for biochemical tests, including evaluating serum urea and creatinine. The kidneys were extracted for histological investigation and evaluation of antioxidant (GSH) and oxidative stress (MDA) by using kidney tissue homogenates. Results: This study revealed that kidney damage, produced by the MTX (group II), is manifested by significantly elevated (P<0.05) urea and creatinine. On the contrary, the cyanocobalamin groups (IV, V, VI) significantly (P<0.05) reduced urea and creatinine. Renal antioxidant defense systems, such as reduced glutathione depleted by MTX therapy, were restored to normal levels by cyanocobalamin. Furthermore, cyanocobalamin reduced oxidative stress (MDA) and histologically reduced renal tissue injury induced by MTX. Conclusions: In conclusion, the study revealed that cyanocobalamin has a nephroprotective action upon MTX-induced renal damage in rats; cyanocobalamin may offer a protective effect, such as antioxidant action.
Neither carrots nor sticks? Challenges surrounding data sharing from the perspective of research funding agencies—A qualitative expert interview study
Authors: Anger Michael , Wendelborn Christian , Winkler Eva C. , Schickhardt Christoph 
Published: September 2022

Background
Data Sharing is widely recognised as crucial for accelerating scientific research and improving its quality. However, data sharing is still not a common practice. Funding agencies tend to facilitate the sharing of research data by both providing incentives and requiring data sharing as part of their policies and conditions for awarding grants. The goal of our article is to answer the following question: What challenges do international funding agencies see when it comes to their own efforts to foster and implement data sharing through their policies?

Methods
We conducted a series of sixteen guideline-based expert interviews with representatives of leading international funding agencies. As contact persons for open science at their respective agencies, they offered their perspectives and experiences concerning their organisations’ data sharing policies. We performed a qualitative content analysis of the interviews and categorised the challenges perceived by funding agencies.

Results
We identify and illustrate six challenges surrounding data sharing policies as perceived by leading funding agencies: The design of clear policies, monitoring of compliance, sanctions for non-compliance, incentives, support, and limitations for funders’ own capabilities. However, our interviews also show how funders approach potential solutions to overcome these challenges, for example by coordinating with other agencies or adjusting grant evaluation metrics to incentivise data sharing.

Discussion and conclusion
Our interviews point to existing flaws in funders’ data sharing policies, such as a lack of clarity, a lack of monitoring of funded researchers’ data sharing behaviour, and a lack of incentives. A number of agencies could suggest potential solutions but often struggle with the overall complexity of data sharing and the implementation of these measures. Funders cannot solve each challenge by themselves, but they can play an active role and lead joint efforts towards a culture of data sharing.
Blood pressure variability and early neurological deterioration according to the chronic kidney disease risk categories in minor ischemic stroke patients
Authors: Ryu Jae-Chan , Bae Jae-Han , Ha Sang Hee , Chang Jun Young , Kang Dong-Wha , Kwon Sun U. , Kim Jong S. , Baek Chung Hee , Kim Bum Joon 
Published: September 2022

Objective
Chronic kidney disease (CKD) increases blood pressure variability (BPV) and affects stroke outcomes. However, the effect of BPV on early neurological deterioration (END) may be different according to the renal function.

Methods
We enrolled ischemic stroke patients with a National Institutes of Health Stroke Scale of ≤5. END was defined as worsening of ≥1 point in motor power or ≥2 points in total score. BPV was calculated with BP measured during the first 5 days and presented as standard deviation (SD) and coefficient of variation (CoV). Renal function was classified using the Kidney Disease Improving Global Outcomes (KDIGO) classification of CKD. Variables were compared between those with (KDIGO classification: moderate- to very-high-risk) and without renal impairment (KDIGO classification: low-risk) and factors associated with END were investigated.

Results
Among the 290 patients (136 [46.9%] renal impairment), END was observed in 59 (20.3%) patients. BPV parameters and the risk of END increased as renal function was impaired. Renal function and systolic BP (SBP) mean, SD, CoV, and diastolic BP (DBP) mean, SD were independently associated with END. We found no association between BPV parameters and END in normal renal function patients; however, among impaired renal function patients, SBP SD (odds ratio [OR]: 1.20, 95% confidence interval [CI]: 1.09–1.32, P<0.001) and CoV (1.30 [1.12–1.50], P<0.001) were associated with END.

Conclusions
The association between END and BPV parameters differs according to renal function in minor ischemic stroke; BPV was associated with END in patients with renal impairment, but less in those with normal renal function.
HUBUNGAN ANTARA SENSE OF COMMUNITY DENGAN PROKRASTINASI AKADEMIK PADA MAHASISWA FAKULTAS PSIKOLOGI UNIVERSITAS DIPONEGORO SEMARANG
Authors: Purwantika Widiantisari , Setyawan Imam , Ariati Jati 
Published: September 2022

Penelitian bertujuan untuk mengetahui hubungan antara sense of community dengan prokrastinasi akademik pada mahasiswa Fakultas Psikologi Universitas Diponegoro Semarang. Sense of community adalah perasaaan memiliki tujuan bersama, saling menghargai, mendukung usaha satu sama lain, serta percaya bahwa setiap orang memberi kontribusi yang penting bagi pembelajaran antara mahasiswa, dosen, dan tenaga kependidikan. Prokrastinasi akademik adalah penundaan dalam memulai, proses mengerjakan, dan penyelesaian tugas akademik yang penting dan seharusnya dapat diselesaikan tepat waktu. Populasi penelitian adalah mahasiswa Fakultas Psikologi Universitas Diponegoro Semarang angkatan 2009, 2010, dan 2011 sebanyak 496 mahasiswa. Sampel penelitian berjumlah 124 orang yang diperoleh melalui teknik proportional stratified random sampling. Alat pengumpul data dalam penelitian menggunakan dua buah skala yaitu Skala Prokrastinasi Akademik yang terdiri atas 38 item (α = 0,935) dan Skala Sense of Community yang terdiri atas 42 item (α = 0,925). Hasil analisis data dengan metode uji korelasi menghasilkan koefisien korelasi (rxy) sebesar -0,421 dengan p = 0,000 (p<0,05). Hasil tersebut menunjukkan arah hubungan negatif yang signifikan antara sense of community dengan prokrastinasi akademik pada mahasiswa Fakultas Psikologi Universitas Diponegoro Semarang angkatan 2009, 2010, dan 2011. Semakin tinggi sense of community maka semakin rendah prokrastinasi akademik atau sebaliknya.
HUBUNGAN ANTARA KONTROL DIRI DENGAN KECENDERUNGAN KECANDUAN MEDIA SOSIAL PADA REMAJA AKHIR
Authors: Muna Resti Fauzul , Astuti Tri Puji 
Published: September 2022

Kecenderungan kecanduan media sosial adalah fenomena yang sering terjadi pada saat ini seiring dengan meningkatnya penggunaan internet serta canggihnya kemajuan teknologi. Terjadinya kecenderungan kecanduan media sosial dipengaruhi oleh beberapa faktor, diantaranya adalah faktor kontrol diri. Penelitian ini bertujuan untuk mengetahui: (1) Hubungan antara kontrol diri dengan kecenderungan kecanduan media sosial pada remaja, dan (2) Seberapa besar peran kontrol diri terhadap kecenderungan kecanduan media sosial.
Sampel dalam penelitian ini adalah 164 orang yang diperoleh dengan menggunakan teknik sampling incidental. Analisis data yang telah terkumpul dilakukan dengan teknik analisis regresi sederhana untuk mengetahui hubungan antara dua variabel yang diteliti. Berdasarkan hasil analisis statistik, diperoleh hasil Rxy = -0,369 dengan p = 0,000 (p