bluuebunny/crossref_metadata_2025_split huggingface dataset:
MANEJO DAS MICROBACIAS HIDROGRÁFICAS: AS GEOTECNOLOGIAS EM SUAS PARTICULARIDADES APLICADAS AO CÓRREGO DA CAÇADA (ITUIUTABA-MG)
Authors: Zanetoni Penariol Rafael , Ferreira Barcelos Luiz Felipe , Barboza Castanho Roberto 
Published: November 2022

A microbacia hidrográfica é um sistema natural cuja sua base é formada pela água, e que se relaciona com outros elementos, sejam eles naturais ou sociais, durante esta pesquisa buscou-se apontar estas relações supracitadas no Córrego da Caçada, Localizado no municio de Ituiutaba – MG/Brasil, utilizando os elementos que englobam as geotecnologias, dando ênfase as aplicabilidades do sensoriamento remoto no software QGIS no que tange a sua ferramenta Taudem. Esta investigação acadêmica, objetiva demonstrar técnicas de estudo que auxiliam a análise da utilização e degradação dos recursos hídricos, mais especificamente aquelas integradas as microbacias, e com isso auxiliando na compreensão acerca dos processos que trazem a esta ciência uma nova percepção. No recorrer desta, optou-se por realizar os mapeamentos de ipsometria, hierarquização fluvial e uso e ocupação do solo da área utilizada, concluindo-se que as geotecnologias possuem capacidade em auxiliar a produção de atividades relacionadas às microbacias mesmo com algumas objeções.
Heterogeneous phenotype of autoinflammatory disease in a patient with mutations in NOD2 and MEFV genes
Authors: Abrego Fuentes Laura Edith , Chair Irene , Vadas Peter , Roifman Chaim M. 
Published: November 2022

Background: Autoinflammatory diseases are a genetically heterogeneous group of conditions characterized by excessive activation of the innate immune system. They frequently present with overlapping features, particularly in cases of digenic or polygenic inheritance. The most common cause of autoinflammation arises from causative variants in the MEFV gene, responsible for familial Mediterranean fever. Clinical features include recurrent episodes of fever with serositis and amyloidosis. Individuals with variants in MEFV that present atypically with heterogeneous autoinflammatory features have also been described. Notably, gene modifiers of MEFV, such as NOD2 encoding an intracellular bacterial sensor, can result in more severe disease. NOD2 underlies a number of autoinflammatory and immunodeficiency conditions, including Blau syndrome. To date, Blau syndrome has not been described in the context of MEFV. Aim: To expand the presentation and phenotype of autoinflammatory disease associated with defects in the NOD2 and MEFV genes. Methods: A retrospective review of the patient’s chart was performed, including family history, medical history, immune laboratory evaluation, and genetics. Results: We describe here a 68-year-old male with a remarkable medical history since childhood of skin rash, erythroderma, recurrent infections, autoinflammation, arthritis, uveitis, and malignancy. A significant family history of cancer and autoinflammation was noted. Genetic work-up involving a 17-gene autoinflammatory panel revealed 3 heterozygous variants of uncertain significance, 2 of which were present in the MEFV gene and one in the NOD2 gene. His features were consistent with an overlapping phenotype of Blau syndrome and atypical FMF. Conclusion: Heterozygous variants in NOD2 and MEFV can result in a spectrum of autoinflammatory disorders with a heterogeneous phenotype. The NOD2 variant identified in our patient has not previously been associated with Blau syndrome. Statement of Novelty: We describe a patient harbouring heterozygous mutations in the MEFV and NOD2 genes marked by recurrent childhood infections.
Whole exome sequencing identifies causative compound heterozygous variants in PRF1 in late-onset familial hemophagocytic lymphohistiocytosis
Authors: Sham Marina , Zhu Rongbo , Merico Daniele , Pasternak Yehonatan 
Published: November 2022

Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disease in which cells of the immune system are overactivated, leading to uncontrolled inflammation and tissue destruction. Inherited or familial forms of HLH (FHL) are further classified into FHL1 to 5, based on the underlying genetic etiology. The most common form, FHL2, is associated with mutations in the PRF1 gene encoding perforin, a pore-forming glycoprotein required for natural killer and cytotoxic T cell-mediated apoptosis. Importantly, diagnosis of FHL can be challenging, particularly in late-onset cases in which presentation is delayed beyond the first years of life. Aim: We report the essential role of whole exome sequencing in the diagnostic work-up of a patient with complex, late-onset FHL. Methods: A comprehensive retrospective chart review was performed. Results: Our patient presented at 11 years of age with recurrent fever, hepatosplenomegaly, and pancytopenia. In the following years, she was admitted to hospital on multiple occasions, including twice for febrile neutropenia, and once for febrile cytopenia. Serial immune evaluation revealed features of immune dysregulation. While HLH was suspected, she did not fulfil the diagnostic criteria. Initial genetic work-up involving a targeted primary immunodeficiency gene panel identified only a single novel variant of uncertain significance, c.T374C (p.I125T) in PRF1. Subsequently, research-based whole exome sequencing was performed which revealed a second variant, c.C272T (p.A91V), in the same gene. The expanded genetic findings, a set of compound heterozygous missense mutations in PRF1, strengthened the diagnosis of FHL. She later fulfilled the diagnostic criteria for HLH. Conclusion: Whole exome sequencing identified compound heterozygous mutations in the PRF1 gene in a patient with late-onset FHL. Statement of Novelty: We report the use of whole exome sequencing to identify compound heterozygous mutations in PRF1, including a novel p.I125T variant not previously identified in FHL.
The ANKK1/DRD2 gene TaqIA polymorphism (rs1800497) is associated with the severity of extrapyramidal side effects of haloperidol treatment in CYP2D6 extensive metabolizers with schizophrenia spectrum disorders
Authors: Kibitov Andrey Alexandrovitch , Kiryanova Elena Mikhaylovna , Salnikova Ludmila Ivanovna , Bure Irina Vladimirovna , Shmukler Alexander Borisovitch , Kibitov Alexander Olegovitch 
Published: November 2022

Abstract

Objectives
Extrapyramidal symptoms (EPS) are one of the most prominent side effects of haloperidol. Variability of EPS severity may be associated with the genetic factors, affecting both haloperidol pharmacokinetics (e.g., CYP2D6) and pharmacodynamics (e.g., DRD2, ANKK1). We conducted a 3-week prospective study to investigate the associations of ANKK1/DRD2 TaqIA (rs1800497), DRD2 −141C Ins/Del (rs1799732) polymorphisms and CYP2D6 metabolic phenotype on the efficacy of haloperidol treatment and severity of EPS in patients with schizophrenia spectrum disorders.

Methods
In total, 57 inpatients with schizophrenia spectrum disorders (24 (42.1%)) females; age −46.7 (11.8) years (M(SD)) of European ancestry were enrolled. BARS and SAS scales were used to assess EPS. PANSS and CGI scales – to assess the efficacy of haloperidol treatment. Genotyping was performed by real-time PCR. CYP2D6 metabolic phenotype was predicted by the CYP2D6 *3, *4, *5, *6, *9, *10, *41 and xN genotypes.

Results
Minor C allele of TaqIA was associated with higher scores of BARS (p=0.029) and SAS (p=0.024) on day 21 and minor Del allele of −141C Ins/Del – with more prominent clinical improvement by CGI scale (p=0.007) but not by PANSS. These differences were observed only in extensive CYP2D6 metabolizers, although no associations with the metabolic type itself were found. General linear model showed that the combination of TaqIA genotype and metabolic type was significantly associated with BARS score on day 21 (p=0.013).

Conclusions
Our results highlight the importance of using both pharmacokinetic and pharmacodynamic genetic markers for predicting haloperidol treatment response to personalize schizophrenia spectrum disorders treatment.
Enforcing Constitutional Sustainability Clauses in the Age of the Climate Crisis: Insights from Social Contract Theory on How to Take Account of Future Generations
Authors: Kirchmair Lando 
Published: November 2022

Abstract
Climate change is one of the most alarming events today, which will very likely have devastating effects on a lot of people worldwide. This paper addresses the question as to how constitutional sustainability clauses can be enforced in the age of the climate crisis. It does so by looking into some difficulties of making the notion of future generations operable. First, the paper will briefly analyze two decisions by the Austrian Constitutional Court and the Norwegian Supreme Court, which have both rejected claims based on constitutional sustainability clauses referring to future generations. This is juxtaposed with a recent decision by the Federal Constitutional Court of Germany which invigorated Article 20a of the German Basic Law and thereby also future generations. Second, this paper aims at shedding light on the notion of future generations by looking into philosophical debates on the so-called non-identity problem. The question as to how to include future generations in the social contract and selected philosophical strategies to address it are discussed and introduced to the legal discourse. This seems to be a worthwhile goal as by now several scholars from various disciplines such as geography, political science, and applied ecology have opened up a debate on the role of social contracts concerning climate change. This paper seeks to further the debate by aiming to suggest a connection between philosophical social contract reasoning and constitutional sustainability clauses taking the example of Austria, Norway, and Germany.
Effect of cryogenic treatment holding time on mechanical and microstructural properties of Sverker 21 steel
Authors: Özbek Nursel Altan , Özbek Onur 
Published: November 2022

Abstract
This study investigated the effects of shallow and deep cryogenic treatment on the microstructural and mechanical properties of Sverker 21 tool steel. After conventional heat treatment, shallow cryogenic treatment at −80 °C for 2, 12, and 24 h and deep cryogenic treatment at −180 °C for 2, 18, and 36 h were applied on the steel samples. After that, the samples were tempered at 200 °C for 2 h. As a result of these treatments, the steel samples’ hardness, toughness, and wear rate changes were determined, and their microstructural properties were investigated. As a result of the study, it was observed that the cryogenic treatment had positive effects on the mechanical and microstructural properties of Sverker 21 steel. Mechanical properties also improved with increasing holding time for both cryogenic treatment types. It has been found that the deep cryogenic treatment provides better mechanical properties compared to the shallow cryogenic treatment. The maximum hardness and wear resistance were obtained in the deep cryogenically treated sample for 36 h. Compared to the CHT sample, the hardness and impact energy of the DCT(36) sample increased by approximately 11.75% and 17.36%. An improvement of approximately 64% was observed in the wear rate.
Effect of ultra-high boron additions on microstructure and mechanical properties on high chromium steel
Authors: Murathan Ömerfaruk , Kocatepe Kadir , Erdogan Mehmet 
Published: November 2022

Abstract
In this work, the change on the microstructure and mechanical properties of high chromium steel investigated by adding ultra-high boron contents. Specimens produced by casting method. A total of 430 type martensitic stainless steel scraps melted in an induction furnace where the chemical composition of melt controlled (by adding ferro alloys, de-oxidation, removing nitrogen, etc.). At 1550 °C, melt was poured into sand molds with the shape of Y blocks. Wet chemical analysis was used for boron analysis. The change on the microstructure and mechanical properties (hardness test, Charpy impact test and pin on disc abrasive wear test) determined. Experimental results revealed that, martensitic matrix obtained in both boron free steel and ultra-high boron steels. Chromium carbides and borides were embedded each other (M2B and M7(C, B)5 type of carbide/borides) according to X-ray diffraction results. With the change of boron content, carbide/boride volume fraction, distribution and shapes were changed as well. Hardness and abrasion resistance improved for the steels having higher boron contents however impact toughness deteriorated significantly.
Effects of Re and Co additions on lattice parameters and lattice misfit in cast Ni-based superalloys
Authors: Nararak Arpaporn , Kiatwisarnkij Napat , Rojhirunsakool Tanaporn , Dasari Sriswaroop , Nusen Sankum , Lothongkum Gobboon , Lampke Thomas , Hartung Fritz , Qin Jiaqian , Wangyao Panyawat 
Published: November 2022

Abstract
Morphological evolution of gamma prime precipitates was governed by an elemental partitioning ratio between the gamma and gamma prime phases. In the present study, Ni-based MGA 1400 alloy was modified by adding 4 wt% of Re and 6.4 wt% of Co by vacuum arc melting. The effects of Re and Co additions on lattice parameters of gamma and gamma prime phases were studied by TEM and XRD techniques. Calculated lattice misfit values obtained from XRD and TEM techniques were used to identify the shape and morphology of gamma prime precipitated particles after long-term exposure at 1173 K for 1800 ks? After long-term exposure, gamma prime particles became much coarser. The addition of Re retarded the coarsening rate of the gamma prime precipitates, resulting in smaller gamma prime particles at the same annealing times. Even though, both Re and Co atoms are strongly partitioned in the gamma matrix, the effect of Re and Co additions on lattice misfits was contradictory. The addition of Re produced rounded corner cuboidal morphology of gamma prime precipitates due to higher magnitude with negative lattice misfit (−0.3857%), while Co addition provided a more rounded shape of gamma prime particles due to the lattice misfit value approach to zero (+0.0936%).
Szervezeti válaszok a koronavírus járvány harmadik hullámában
Authors: Kőmüves Zsolt , Poór József , Szabó Szilvia 
Published: November 2022

A TANULMÁNY CÉLJA
Tanulmányunk célja nyomon követni, hogy milyen változásokkal reagál a hazai vállalati/intézményi szféra emberi erőforrás menedzselési gyakorlata a koronavírus okozta válság kihívásaira.
ALKALMAZOTT MÓDSZERTAN
Vizsgálatainkat 262, Magyarországi székhellyel rendelkező szervezet HR vezetőinek körében végeztük. A kérdőíves felmérés keretében vizsgáltuk a koronavírus járvány által okozott gazdasági hatásokra adott szervezeti válaszokat. Az adatok értékelésére SPSS programcsomagot használtunk, a háttérváltozók és az egyes válaszok közötti összefüggések kimutatása érdekében kereszttábla elemzést végeztünk, míg a változók közötti összefüggések statisztikai szignifikanciájának mérésére Pearson-féle Khi négyzet (χ2) próbát végeztünk, ezen kívül a kereszttáblás elemzés során megvizsgáltuk a Crammer-féle együtthatót.
LEGFONTOSABB EREDMÉNYEK
A Covid-19 helyzet a gazdasági élet szereplőitől folyamatos alkalmazkodást, és sok esetben komoly változtatásokat kívánt. Érdemes azonban rálátni arra is, hogy a válság nemcsak negatív, de pozitív fejlődési lehetőségeket is hordozott a vállalatok számára. Így a pandémia a válaszadó szervezetek esetén potenciálisan fejlődő területekként jelent meg, a létszámtervezés, toborzási, kiválasztási rendszerek fejlesztése, home office, szociális, mentális támogatás, munkavédelem, belső kommunikáció területén. Ezt igazolták a kutatási eredményeink is, ahol a megkérdezett vállalkozások és intézmények több, mint egyharmada a válságra lehetőségként tekint és mindössze 7,5%-uk utasította el teljesen ezt a megközelítést. A koronavírus járvány további pozitív hozadékaként – kihasználható lehetőségként – említhetjük azt is, hogy megmutatta a vizsgált szervezetek számára azokat a kritikus HR pontokat, amelyek erősítést igényelnek. A járvány az alábbi fejlesztendő területekre hívta fel a figyelmet: belső kommunikáció fejlesztése, képzés, munkavállalói jólét átalakítása.
GYAKORLATI JAVASLATOK
A kutatás eredményei hozzájárulnak a stratégiai döntések megtervezéséhez, a kiválasztási, toborzási módszerek meghatározásához. Eredményeink támpontot, kiindulási alapot jelenthetnek a gyakorló HR szakembereknek (dolgozzanak akár for-profit, akár a non-profit szervezeteknél) a jövő HR szakembereit képzőknek, és a terület kutatóinak is.
Human Brainstem and Cerebellum Atlas: Chemoarchitecture and Cytoarchitecture Paired to MRI
Authors: Agostinelli Lindsay J. , Seaman Scott C. , Saper Clifford B. , Fykstra Dustin P. , Hefti Marco M. , Koscik Timothy R. , Dlouhy Brian J. , Bassuk Alexander G. 
Published: November 2022

Lesion localization is the basis for understanding neurologic disease, which is predicated on neuroanatomical knowledge carefully cataloged from histology and imaging atlases. However, it is often difficult to correlate clinical images of brainstem injury obtained by MRI scans with the details of human brainstem neuroanatomy represented in atlases, which are mostly based on cytoarchitecture using Nissl stain or a single histochemical stain, and usually do not include the cerebellum. Here, we report a high-resolution (200 μm) 7T MRI of a cadaveric male human brainstem and cerebellum paired with detailed, coregistered histology (at 2 μm single-cell resolution) of the immunohistochemically stained cholinergic, serotonergic, and catecholaminergic (dopaminergic, noradrenergic, and adrenergic) neurons, in relationship to each other and to the cerebellum. These immunohistochemical findings provide novel insights into the spatial relationships of brainstem cell types and nuclei, including subpopulations of melanin and TH+neurons, and allows for more informed structural annotation of cell groups. Moreover, the coregistered MRI-paired histology helps validate imaging findings. This is useful for interpreting both scans and histology, and to understand the cell types affected by lesions. Our detailed chemoarchitecture and cytoarchitecture with corresponding high-resolution MRI builds on previous atlases of the human brainstem and cerebellum, and makes precise identification of brainstem and cerebellar cell groups involved in clinical lesions accessible for both laboratory scientists and clinicians alike.SIGNIFICANCE STATEMENTClinicians and neuroscientists frequently use cross-sectional anatomy of the human brainstem from MRI scans for both clinical and laboratory investigations, but they must rely on brain atlases to neuroanatomical structures. Such atlases generally lack both detail of brainstem chemical cell types, and the cerebellum, which provides an important spatial reference. Our current atlas maps the distribution of key brainstem cell types (cholinergic, serotonergic, and catecholaminergic neurons) in relationship to each other and the cerebellum, and pairs this histology with 7T MR images from the identical brain. This atlas allows correlation of the chemoarchitecture with corresponding MRI, and makes the identification of cell groups that are often discussed, but rarely identifiable on MRI scan, accessible to clinicians and clinical researchers.
Influence of ionic liquid (IL) treatment conditions in the regeneration of cellulose with different crystallinity
Authors: Rana Md. Mohosin , De la Hoz Siegler Hector 
Published: November 2022

AbstractIn this study, we treated microcrystalline cellulose (MCC) with the ionic liquid (IL) 1-butyl-3-methylimmidazolium chloride (BMIMCl) to elucidate the effects that IL treatment conditions have on the properties of amorphized cellulose (AC). Analysis of X-ray diffractograms confirmed that after 20 min of IL treatment AC crystallinity was reduced from 77.7 to 57.1%. After 10 h of IL treatment, AC crystallinity decreased to 29.6%. Chemical and morphological changes in the regenerated AC were determined via FT-IR and SEM studies. The rapid transformation of crystalline cellulose domains into amorphous domains is linked to the small MCC particle size (20 μm) and the presence of a moisture-free condition during IL treatment. Thermal stability of the treated cellulose, as determined by TGA and DSC profiling, decreased as the crystallinity index decreased. The high tunability of cellulose crystallinity by IL treatment provides a facile way for designing more efficient hybrid bioactive materials for biomedical applications.
Graphical abstract
Love waves in multilayered media with irregular interfaces: I. Modal solutions and excitation formulation
Authors: Chen Xiaofei 
Published: November 2022

Abstract
In this article, we present a new formulation of Love waves in arbitrarily irregular multilayered media by using the global generalized reflection/transmission matrices method (abbreviated to GGRTM; Chen, 1990, 1995, 1996). From the basic principle that the modal solutions are the nontrivial solutions of the free elastodynamic equation under appropriate boundary conditions, we naturally derived the characteristic frequencies and the corresponding distorted modes of Love wave in irregular multilayered media. The basic principle used here for defining modal solutions is a general one. It is identical to that used for defining normal mode solutions in laterally homogeneous-layered media (Chen, 1993) and that used for determining the resonant modes in finite-scatters case (e.g., sedimentary basin structure; see Zhou and Dravinski, 1994) and is independent of any particular mathematical technique. We found that the distorted mode in 2D structure is nonseparable in (x, z) coordinates, that is, wn,v(x,z)=∑m{a(z,ωn,v)}meikmx; whereas the normal mode for 1D structure is separable in (x,z) coordinates: un,v(x,z) = l(z,ωn,v)eiknx. Based on the formulation of GGRTM and the modal solutions, we also analytically derive the excitation formula of Love waves in irregular multilayered media, that is, the formulation of synthetic Love waves due to an arbitrarily seismic point source in such lateral heterogeneous media. We found that the synthetic Love wave in time domain can be expressed as a superposition of a series of distorted modes that is similar to the excitation formula of classic Love waves. Since the structure model used here is quite arbitrary, the new formulation of Love waves derived in this article can be applied to study a variety of seismological problems ranging from resonated motion in a sedimentary basin structure to excitation of Love waves in irregular multilayered media. It offers an alternative mean to understand the nature of Love waves in laterally heterogeneous media.