bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual Surgeries of Nasal Cavities Using a Coupled Lattice-Boltzmann–Level-Set Approach
Authors: Waldmann Moritz , Rüttgers Mario , Lintermann Andreas , Schröder Wolfgang 
Published: March 2022

Abstract
Fluid mechanical properties of respiratory flow such as pressure loss, temperature distribution, or wall-shear stress characterize the physics of a nasal cavity. Simulations based on computational fluid dynamics (CFD) methods are able to deliver in-depth details on respiration. Integrating such tools into virtual surgery environments may support physicians in their decision-making process. In this study, a lattice-Boltzmann (LB) flow solver is coupled to a level-set (LS) method to modify the shape of a nasal cavity at simulation run time in a virtual surgery. The geometry of a presurgical nasal cavity obtained from computer tomography (CT) datasets is smoothly adapted toward a postsurgical geometry given by the surgeon using an interpolation approach based on a LS method. The influence of the modification on the respiratory flow is analyzed in silico. The methods are evaluated by simulating a virtual surgery of a stenotic pipe and juxtaposing the results to cases using static geometries and by comparing them to literature findings. The results for both the stenotic pipe and the nasal cavity are in perfect agreement with the expected outcomes. For the nasal cavity, a shape is found that reduces the nasal resistance by 25.3% for inspiration at a volumetric flow rate of V˙=250 ml/s. The heating capability is retained despite the geometry modification. The simulation results support the surgeon in evaluating a planned surgery and in finding an improved surgery for the patient.
Agreement Between Sagittal Foot and Tibia Angles During Running Derived From an Open-Source Markerless Motion Capture Platform and Manual Digitization
Authors: Johnson Caleb D. , Outerleys Jereme , Davis Irene S. 
Published: March 2022

Several open-source platforms for markerless motion capture offer the ability to track 2-dimensional (2D) kinematics using simple digital video cameras. We sought to establish the performance of one of these platforms, DeepLabCut. Eighty-four runners who had sagittal plane videos recorded of their left lower leg were included in the study. Data from 50 participants were used to train a deep neural network for 2D pose estimation of the foot and tibia segments. The trained model was used to process novel videos from 34 participants for continuous 2D coordinate data. Overall network accuracy was assessed using the train/test errors. Foot and tibia angles were calculated for 7 strides using manual digitization and markerless methods. Agreement was assessed with mean absolute differences and intraclass correlation coefficients. Bland–Altman plots and paired t tests were used to assess systematic bias. The train/test errors for the trained network were 2.87/7.79 pixels, respectively (0.5/1.2 cm). Compared to manual digitization, the markerless method was found to systematically overestimate foot angles and underestimate tibial angles (P < .01, d = 0.06–0.26). However, excellent agreement was found between the segment calculation methods, with mean differences ≤1° and intraclass correlation coefficients ≥.90. Overall, these results demonstrate that open-source, markerless methods are a promising new tool for analyzing human motion.
Geologic map of central Panamint Range, California, USA
Authors: Andrew Joseph E. 
Published: March 2022

Abstract
This detailed geologic map and supplemental digital data set1 examine and demonstrate the complex deformational history and reactivation relationships of the Panamint Range (California, USA), from active transtension of the Walker Lane belt, Miocene extension of the Basin and Range, to multiple Mesozoic events related to subduction, and Neoproterozoic extension. This collection of map data focuses on the geometry, kinematics, and relative timing of deformation to understand the deformation history and effects of structural reactivation. A minor portion of this geologic mapping data was presented in the analysis and figures of Andrew and Walker (2009).
The Neogene extension and subsequent dextral transtension deformation has created a complex network of faults via partial reactivation of Mesozoic and Neoproterozoic structures. Structural data show oblique normal slip overprinting earlier normal slip along the western range flank fault of the western Panamint Range. Jurassic and Cretaceous deformation is localized along the western range on the Goldbug fault. The hanging wall of this fault preserves migmatitic fabrics and intense deformation due to Jurassic contraction. The Goldbug fault places Paleoproterozoic to Mesoproterozoic rocks over Neoproterozoic rocks. The Jurassic contraction has top-to-the-northeast relative transport and the more discrete Cretaceous thrust faulting has top-to-the-east transport. A set of Late Cretaceous plutonic rocks and mylonitic gneisses derived from them, occur along the Goldbug fault and demonstrate the reactivated nature of this fault in the Late Cretaceous. New data for the Butte Valley fault show that this fault cuts Late Jurassic plutonic rocks and has normal slip. The Butte Valley fault ends northward at the linked sinistral slip Warm Spring Canyon fault, which was previously interpreted to be an intrusive contact. A previously unrecognized rim syncline structure occurs along the boundary of the Late Jurassic Manly Peak quartz monzonite. Neoproterozoic deformation is difficult to discern due to the overprinting deformations. Numerous Neoproterozoic deformation-related mass wasting deposits can be seen within this formation, including a set of conspicuous allochthonous deposits and clasts of older Beck Spring Dolomite that appear to be frozen in the process of breaking away from intact, normal thickness beds in the Surprise–Happy Canyons divide.
This detailed geologic mapping and collection of structural data for the rocks in the central Panamint Range were created using digital in-the-field geographic information systems software running on a field-hardened laptop computer combined with an earlier set of field data that were digitized into the digital georeferenced database. This map is a simplification of detailed geologic mapping data collected at 1:2000–1:6000 scales and reduced to 1:20000 scale. Structural data include kinematic and relative timing of deformation information.
Time to positivity of blood cultures in neonatal late-onset bacteraemia
Authors: Mukhopadhyay Sagori , Briker Sara M , Flannery Dustin D , Dhudasia Miren B , Coggins Sarah A , Woodford Emily , Walsh Eileen M , Li Sherian , Puopolo Karen M , Kuzniewicz Michael W 
Published: March 2022

ObjectiveTo determine the time to positivity (TTP) of blood cultures among infants with late-onset bacteraemia and predictors of TTP >36 hours.DesignRetrospective cohort study.Setting16 birth centres in two healthcare systems.PatientsInfants with positive blood cultures obtained >72 hours after birth.OutcomeThe main outcome was TTP, defined as the time interval from specimen collection to when a neonatal provider was notified of culture growth. TTP analysis was restricted to the first positive culture per infant. Patient-specific and infection-specific factors were analysed for association with TTP >36 hours.ResultsOf 10 235 blood cultures obtained from 3808 infants, 1082 (10.6%) were positive. Restricting to bacterial pathogens and the first positive culture, the median TTP (25th–75th percentile) for 428 cultures was 23.5 hours (18.4–29.9); 364 (85.0%) resulted in 36 hours. Excluding coagulase-negative staphylococci (CoNS), 275 of 294 (93.5%) cultures were flagged positive by 36 hours. In a multivariable model, CoNS isolation and antibiotic pretreatment were significantly associated with increased odds of TTP >36 hours. Projecting a 36-hour empiric duration at one site and assuming that all negative evaluations were associated with an empiric course of antibiotics, we estimated that 1164 doses of antibiotics would be avoided in 629 infants over 10 years, while delaying a subsequent antibiotic dose in 13 infants with bacteraemia.ConclusionsEmpiric antibiotic administration in late-onset infection evaluations (not targeting CoNS) can be stopped at 36 hours. Longer durations (48 hours) should be considered when there is pretreatment or antibiotic therapy is directed at CoNS.
Development and validation of a questionnaire-based myopia proxy in adults: the LifeLines Cohort Study
Authors: Asefa Nigus G , Neustaeter Anna , Vehof Jelle , Nolte Ilja M , Snieder Harold , Jansonius Nomdo M 
Published: March 2022

AimsTo build a questionnaire-based myopia proxy and to validate the proxy by confirming its association with educational attainment and a Polygenic Risk Score (PRS) for myopia.MethodsData were collected between 2014 and 2017 from 88 646 Dutch adults from the LifeLines Cohort. First, we performed principal component analysis (PCA) to responses of five refraction-status questions. Second, we measured the refractive state in a subset of LifeLines participants (n=326) and performed logistic regression using myopia (mean spherical equivalent <−0.5 D) as a dependent variable and the principal components (PCs) as independent variables. We identified specificity, sensitivity and the classification threshold. Third, the classification equation was applied to the remaining LifeLines participants. The value of the proxy was then explored by calculating its association with educational attainment and a PRS of myopia.ResultsA total of 77 096 participants (58.1% women) were eligible for the PCA. The first two PCs had a specificity of 91.9% (95% CI 87.8% to 95.4%) and a sensitivity of 90.4% (95% CI 84.3% to 96.4%) for myopia. The area under the receiver operating characteristic curve was 95.0% (95% CI 92.2% to 97.8%). The age-standardised prevalence of proxy-inferred myopia was 33.8% (95% CI 33.4% to 34.3%). Compared with low education level, the ORs of proxy-inferred myopia were 1.66 (95% CI 1.58 to 1.74, p=5.94×10−90) and 2.54 (95% CI 2.41 to 2.68, p=4.04×10−271) for medium and high education levels, respectively. Similarly, individuals at the top 10% of PRS (vs lower 90%) had an OR of 2.18 (95% CI 1.98 to 2.41, p=6.57×10−56) for proxy-inferred myopia, whereas those at the highest decile had an OR of 4.51 (95% CI 3.9 to 5.21, p=1.74×10−89) when compared with the lowest decile.ConclusionSelf-administered refractive error-related questions could be used as an effective tool to capture proxy-inferred myopic cases in a population-based setting.
COVID-19-related occupational stress in staff in an acute paediatric teaching hospital in Ireland
Authors: Murray Johanna , Adamis Dimitrios , McNicholas Fiona 
Published: March 2022

BackgroundThe COVID-19 pandemic has resulted in major strains for healthcare staff.ObjectivesThis study aims to assess prevalence of occupational burnout (BO) during COVID-19 in staff working in an acute paediatric hospital setting.ParticipantsOne hundred and thirty-three staff, out of 1900 eligible staff (9.6% response rate), completed an online or paper and pencil survey.MethodsThe Copenhagen Burnout Inventory was used as the main outcome measure. Additional questions examined the impact of COVID-19 and restrictions on work setting and personal health.ResultsThe majority of respondents reported moderate or higher levels of BO for personal (n=93; 70%) and work domains (n=83; 62%). Rates of patient-related BO were lower (n=18; 13%). Higher rates of BO were found in staff with self-rated COVID-19 adverse effects on physical (n=50, 38%) and mental health (n=88, 66%) (F (2, 13.019)=16.019, p<0.001). The majority of staff had no stress reduction training at any stage in their career, either professional (60%), on the job (62%) or postpandemic (59%) work. Although most (82%) were aware of occupational health supports, few (30%) reported an intention to access these if needed; 65% (n=86) of the respondents seriously considered changing jobs in the last 6–12 months.ConclusionHigh level of occupational stress among hospital staff during COVID-19, in the absence of stress reduction training is a risk factor for BO. Interventions, acceptable to the employee, are urgently needed given the likelihood of additional work demands as COVID-19 continues.
Serial rotational thromboelastography (ROTEM) in mechanically ventilated patients with COVID-19 demonstrates hypercoagulopathy despite therapeutic heparinization
Authors: Choi James K , Prabhakaran Kartik , Latifi Rifat , Smiley Abbas , Klein Joshua , Lombardo Gary , Rhee Peter 
Published: March 2022

BackgroundClinical hypercoagulopathy in patients with COVID-19 has been anecdotally described, but there is lack of evidence due to the novelty of this disease. Our study reports the results of rotational thromboelastography (ROTEM) in relation to traditional laboratory coagulation tests and acute phase markers among a cohort of severely ill, mechanically ventilated patients with COVID-19.MethodsPatients with COVID-19 (N=21) with respiratory failure requiring mechanical ventilation were included in this prospective case series. ROTEM was serially obtained for all patients on three different days during their intensive care unit (ICU) stay and analyzed using repeated measures analysis. Demographic variables, symptoms at the time of presentation, ROTEM values, laboratory values for traditionally measured coagulation profiles, and acute phase reactants were analyzed, in addition to the use of anticoagulation and clinical hypercoagulopathic complications.ResultsThe average age of our cohort was 57.9 years old (SD=14.4) and 76.2% were male. The mortality rate was 14.3% (3 of 21). Two patients (12.5%) were identified to have new-onset deep vein thrombosis, two patients (12.5%) were found to have ≥3 episodes of central venous catheter thrombosis, and three patients (18.7%) had confirmed stroke. ROTEM demonstrated elevated EXTEM and INTEM clotting times, including elevated FIBTEM maximum clot firmness (MCFFIB). All patients treated with therapeutic anticoagulation still demonstrated hypercoagulopathy within the MCFFIBtests.DiscussionRepeated measure ROTEMs were able to detect hypercoagulopathy in ICU patients with COVID-19 despite therapeutic anticoagulation with heparin.Level of evidenceIII.
Example of a sinkhole landscaping project within the close protection area of a drinking water catchment at Saffré (France, Loire-Atlantique)
Authors: Mondain Paul-Henri 
Published: March 2022

Abstract
The frequent sinkholes along the temporary water streams in Saffré basin can be compared with those occurring in Upper Normandy which are commonly referred to as ‘bétoires’. These collapses are not directly linked to karst cavities. They result from a draw-off effect of fine particles contained in the Plio-Quaternary alluvium lying above the carbonate Oligocene series. The draw-off phenomenon appears through fine cracks (1 to a few millimetres) open in soft palustrine limestones broadly comparable with chalk. Based on the knowledge of backfilling work design undertaken at some ‘bétoires’ in Upper Normandy, a new project was undertaken at four sinkhole funnels, which appeared near the surface in the Saffré basin at the end of the winter in 2017. The works consisted of digging the decompressed surface and filling up the excavation pit with materials of decreasing granulometry from bottom to top in order to ease the surface water infiltration through the identified fractured zones to the bottom of the excavation. This design was also complemented by the implementation of a filtering trench in between the watercourse and the filtering bed, laid above the fractured zones, which were enlarged by the dissolution process, on the one hand, and by the construction of a pipe network on top of the filtering bed to allow for pressurized air exhaust towards the surface, on the other hand. The pressurized air comes up from the aquifer as it recharges as soon as the surface water streamflow resumes and takes part in the mechanism, leading to sinkhole collapse, which should be prevented by this backfilling design.
String Diagram Rewrite Theory I: Rewriting with Frobenius Structure
Authors: Bonchi Filippo , Gadducci Fabio , Kissinger Aleks , Sobocinski Pawel , Zanasi Fabio 
Published: March 2022

String diagrams are a powerful and intuitive graphical syntax, originating in theoretical physics and later formalised in the context of symmetric monoidal categories. In recent years, they have found application in the modelling of various computational structures, in fields as diverse as Computer Science, Physics, Control Theory, Linguistics, and Biology.
In several of these proposals, transformations of systems are modelled as rewrite rules of diagrams. These developments require a mathematical foundation for string diagram rewriting: whereas rewrite theory for terms is well-understood, the two-dimensional nature of string diagrams poses quite a few additional challenges.
This work systematises and expands a series of recent conference papers, laying down such a foundation. As a first step, we focus on the case of rewrite systems for string diagrammatic theories that feature a Frobenius algebra. This common structure provides a more permissive notion of composition than the usual one available in monoidal categories, and has found many applications in areas such as concurrency, quantum theory, and electrical circuits. Notably, this structure provides an exact correspondence between the syntactic notion of string diagrams modulo Frobenius structure and the combinatorial structure of hypergraphs.
Our work introduces a combinatorial interpretation of string diagram rewriting modulo Frobenius structures in terms of double-pushout hypergraph rewriting. We prove this interpretation to be sound and complete and we also show that the approach can be generalised to rewriting modulo multiple Frobenius structures. As a proof of concept, we show how to derive from these results a termination strategy for Interacting Bialgebras, an important rewrite theory in the study of quantum circuits and signal flow graphs.
Power-optimized Deployment of Key-value Stores Using Storage Class Memory
Authors: Kassa Hiwot Tadese , Akers Jason , Ghosh Mrinmoy , Cao Zhichao , Gogte Vaibhav , Dreslinski Ronald 
Published: March 2022

High-performance flash-based key-value stores in data-centers utilize large amounts of DRAM to cache hot data. However, motivated by the high cost and power consumption of DRAM, server designs with lower DRAM-per-compute ratio are becoming popular. These low-cost servers enable scale-out services by reducing server workload densities. This results in improvements to overall service reliability, leading to a decrease in the total cost of ownership (TCO) for scalable workloads. Nevertheless, for key-value stores with large memory footprints, these reduced DRAM servers degrade performance due to an increase in both IO utilization and data access latency. In this scenario, a standard practice to improve performance for sharded databases is to reduce the number of shards per machine, which degrades the TCO benefits of reduced DRAM low-cost servers. In this work, we explore a practical solution to improve performance and reduce the costs and power consumption of key-value stores running on DRAM-constrained servers by using Storage Class Memories (SCM).
SCMs in a DIMM form factor, although slower than DRAM, are sufficiently faster than flash when serving as a large extension to DRAM. With new technologies like Compute Express Link, we can expand the memory capacity of servers with high bandwidth and low latency connectivity with SCM. In this article, we use Intel Optane PMem 100 Series SCMs (DCPMM) in AppDirect mode to extend the available memory of our existing single-socket platform deployment of RocksDB (one of the largest key-value stores at Meta). We first designed a hybrid cache in RocksDB to harness both DRAM and SCM hierarchically. We then characterized the performance of the hybrid cache for three of the largest RocksDB use cases at Meta (ChatApp, BLOB Metadata, and Hive Cache). Our results demonstrate that we can achieve up to 80% improvement in throughput and 20% improvement in P95 latency over the existing small DRAM single-socket platform, while maintaining a 43–48% cost improvement over our large DRAM dual-socket platform. To the best of our knowledge, this is the first study of the DCPMM platform in a commercial data center.
Dietary γ-Aminobutyric Acid (GABA) Promotes Growth and Resistance to Vibrio alginolyticus in Whiteleg Shrimp Litopenaeus vannamei
Authors: Bae Jinho , Hamidoghli Ali , Farris Nathaniel W. , Olowe Olumide Samuel , Choi Wonsuk , Lee Seunghan , Won Seonghun , Ohh Mihyang , Lee Seunghyung , Bai Sungchul C. 
Published: March 2022

An 8-week feeding trial was conducted to evaluate the effects of dietary γ-aminobutyric acid (GABA) on growth performance, immune response, and disease resistance for juvenile whiteleg shrimp, Litopenaeus vannamei. Five isonitrogenous diets were formulated by supplementing 0 (CON), 50 (GABA50), 100 (GABA100), and 300 (GABA300) mg of GABA and 4 g of oxytetracycline (OTC) per kilogram of diet. A total of 225 juvenile whiteleg shrimp with an initial weight of

2.97
±
0.06

g were randomly distributed and reared in 15 aquaria as triplicates. After 8 weeks of the feeding trial, weight gain, specific growth rate, feed efficiency, and protein efficiency ratio of shrimp fed GABA100 were significantly higher than those of shrimp fed CON, GABA50, and GABA300 diets (

P
<
0.05

). However, there were no significant differences among shrimp fed CON, GABA50, GABA300, and OTC diets (

P
>
0.05

). After nine days of challenge test with Vibrio alginolyticus, the average cumulative survival rate of shrimp fed GABA50, GABA100, and OTC was significantly higher than that of shrimp fed GABA300 and CON diets (

P
<
0.05

). These results may suggest that 100 mg dietary GABA supplementation (including endogenous GABA, 175.6 mg/kg diet) per kilogram of diet could be the optimum dietary level to replace antibiotics and improve growth performance and disease resistance in whiteleg shrimp L. vannamei.
Neoadjuvant Approaches in Hepatocellular Carcinoma: There's No Time Like the Present
Authors: Franses Joseph W. , Zhu Andrew X. 
Published: March 2022

Abstract
Hepatocellular carcinoma (HCC) remains a lethal malignancy and is an increasingly common cause of cancer death worldwide. Curative-intent surgical resection remains the standard of care for eligible patients, yet outcomes remain poor for many patients, with most patients experiencing recurrence in the 5 years after resection. There is currently significant interest in using locoregional and systemic therapies—in both the neoadjuvant and adjuvant settings—to increase the chance of cure. This review article appraises the existing literature and current clinical trial landscape of neoadjuvant therapies in HCC.