bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID‐19 behavioral questionnaire (CoBQ): Comparing the pandemic's impact on health behavior in three US states
Authors: Mercadante Amanda R. , Chu Vivian , Chen Aleda M. H. , Wong Jason C. , Khare Manorama M. , Law Anandi V. 
Published: April 2022

AbstractBackgroundThe COVID‐19 pandemic impacted daily routines for a majority of the population, with implications for their health behaviors. Racial and ethnic minorities have been disproportionately impacted by COVID‐19. The novel COVID‐19 Behavioral Questionnaire (CoBQ) was developed in Fall 2020 to provide a means to measure the impact of the COVID‐19 pandemic on the United States population. The study utilized behavioral domains to determine which demographic groups reported that they were made the most vulnerable during Fall‐Winter 2020–2021 of the pandemic.ObjectivesThe study aimed to further validate and test the CoBQ in varied US regions and compare the scores obtained from three states, California, Ohio, and Illinois.MethodsA prospective, multi‐site survey‐based study was designed to further validate and test the 17‐item CoBQ in varied populations. Respondents included patients on routine visits at each pharmacy or clinical site who agreed to complete the survey online via Qualtrics. Data analyses included descriptive statistics, psychometric testing, and comparison of groups using Analysis of Variance.ResultsCompleted surveys (n = 507) between October 2021 and March 2021 were analyzed. Respondents were mostly female, white, and had some college education. The CoBQ showed improved reliability compared with previous testing and strong construct validity through factor analysis. Overall scores were similar between three states. The most impacted groups included those who reported within the 18–49 age group, a yearly household income <$50 000, or education up to high school.ConclusionsThe CoBQ is the first validated tool to measure the negative impact of the COVID‐19 pandemic on health behaviors. Results could serve as a baseline to address the most vulnerable patient groups and support identified behavioral needs during a similar pandemic situation.
Identification of autophagy‐related biomarker and analysis of immune infiltrates in oral carcinoma
Authors: Fu Honghai , Zhao Dianguo , Sun Legang , Huang Yumei , Ma Xiangrui 
Published: April 2022

AbstractBackgroundAutophagy plays a vital role in the progression of the tumor. We aimed to investigate the expression, prognostic value, and immune infiltration of autophagy‐related genes in oral carcinoma via bioinformatics analysis.MethodsThe microarray datasets (GSE146483 and GSE23558) of oral carcinoma were downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) between normal and diseased groups were identified by the Limma package. The screened autophagy‐related gene was further validated by the human protein atlas (HPA) database, TCGA database, and GSE78060 dataset.ResultsA total of 18 upregulated (top 10: EGFR, TNF, FADD, AURKA, E2F1, CHEK1, BRCA1, BIRC5, EIF2AK2, and CSF2) and 31 downregulated (top 10: MAP1LC3A, PARK2, AGT, IGF1, TP53INP1, CXCL12, IKBKB, SESN1, ULK2, and RRAGD) autophagy‐related (DEGs) were identified, and FADD was found to be related to the prognosis of oral cancer patients. Gene set enrichment analysis indicated that FADD‐associated genes were significantly enriched in immune‐related pathways. Moreover, correlation analysis revealed that FADD expression was associated with immune infiltrates. Upregulation of FADD is associated with poor survival and immune infiltrates in oral cancer.ConclusionWe speculated that FADD is involved in the immune regulation of oral cancer, as well as autophagy.
Circulating cell‐free circRNA panel predicted tumorigenesis and development of colorectal cancer
Authors: Qi Le , Pan Ying , Tang Min , Chen Xi 
Published: April 2022

AbstractBackgroundColorectal cancer (CRC) is reported with high morbidity and mortality. Currently, the sensitivity of diagnostic markers for colorectal cancer is low. Therefore, further exploration of new plasma diagnostic markers for early detection of colorectal cancer is of great value. We aimed to explore potential circRNAs in plasma as biomarkers for early diagnosis of CRC.MethodsWe employed the circRNA microarray to investigate dysregulated circRNAs in plasma samples of CRC patients, colorectal adenoma patients (CRA), and healthy controls. Through in‐depth analysis, significantly differentially expressed circRNAs were screened as candidate targets.ResultsEight circRNAs (hsa_circ_104885, hsa_circ_100185, hsa_circ_103171, hsa_circ_001978, hsa_circ_105039, hsa_circ_103627, hsa_circ_101717, and hsa_circ_104192) were obtained as candidate circRNAs with upregulation in CRC comparing with both CRA and healthy control. Through detecting the plasma expression levels of eight candidate targets, we identified three circRNA (hsa_circ_001978, hsa_circ_105039, and hsa_circ_103627) with increased level which were consistent with the microarray results in training set. Further validation found the circRNA panel was consistent with training set. The ROC curve also revealed a high diagnostic ability of hsa_circ_001978, hsa_circ_105039, and hsa_circ_103627 in predicted the CRC from CRA patients (AUC = 0.966) as well as healthy controls (AUC = 0.969).ConclusionOur data suggest that hsa_circ_001978, hsa_circ_105039, and hsa_circ_103627 might be a CRC‐specific biomarker for early diagnosis.
Learning from maternal voices on COVID‐19 vaccine uptake: Perspectives from pregnant women living in the Midwest on the COVID‐19 pandemic and vaccine
Authors: Redmond Michelle L. , Mayes Paigton , Morris Kyla , Ramaswamy Megha , Ault Kevin A. , Smith Sharla A. 
Published: April 2022

AbstractThe aim of this study was to understand COVID‐19 vaccine perceptions and decision‐making among a racially/ethnically diverse population of pregnant and lactating women in the Midwest. Pregnant female participants (N = 27) at least 18 years. or older living in the Midwest were recruited to participate in a maternal voices survey. A mix‐methods approach was used to capture the perceptions of maternal voices concerning the COVID‐19 vaccine. Participants completed an online survey on COVID‐19 disease burden, vaccine knowledge, and readiness for uptake. A total of 27 participants completed the Birth Equity Network Maternal Voices survey. Most participants were African American (64%). Sixty‐three percent intend to get the vaccine. Only 25% felt at‐risk for contracting COVID‐19, and 74% plan to consult their provider about getting the COVID‐19 vaccine. At least 66% had some concerns about the safety of the vaccine. Participants indicated a willingness to receive the COVID‐19 vaccine, especially if recommended by their provider. We found little racial/ethnic differences in perceptions of COVID‐19 and low vaccine hesitancy.
Current State of MRI‐Guided Endovascular Arterial Interventions: A Systematic Review of Preclinical and Clinical Studies
Authors: Nijsink Han , Overduin Christiaan G. , Willems Loes H. , Warlé Michiel C. , Fütterer Jurgen J. 
Published: April 2022

BackgroundMRI guidance of arterial endovascular interventions could be beneficial as it does not require radiation exposure, allows intrinsic blood‐tissue contrast, and enables three‐dimensional and functional imaging, however, clinical applications are still limited.PurposeTo review the current state of MRI‐guided arterial endovascular interventions and to identify the most commonly reported challenges.Study TypeSystematic review.PopulationPubmed, Embase, Web of Science, and The Cochrane Library were systematically searched to find relevant articles. The search strategy combined synonyms for vascular pathology, endovascular therapy, and real‐time MRI guidance.Field Strength/SequenceNo field strength or sequence restrictions were applied.AssessmentTwo reviewers independently identified and reviewed the original articles and extracted relevant data.Statistical TestsResults of the included original articles are reported.ResultsA total of 24,809 studies were identified for screening. Eighty‐eight studies were assessed for eligibility, after which data were extracted from 43 articles (6 phantom, 33 animal, and 4 human studies). Reported technical success rates for animal and human studies ranged between 42% to 100%, and the average complication rate was 5.8% (animal studies) and 8.8% (human studies). Main identified challenges were related to spatial and temporal resolution as well as safety, design, and scarcity of current MRI‐compatible endovascular devices.Data ConclusionMRI guidance of endovascular arterial interventions seems feasible, however, included articles included mostly small single‐center case series. Several hurdles remain to be overcome before larger trials can be undertaken. Main areas of research should focus on adequate imaging protocols with integrated tracking of dedicated endovascular devices.
Supply chain transparency: Consumer reactions to incongruent signals
Authors: Mollenkopf Diane A. , Peinkofer Simone T. , Chu Yu ( Jade) 
Published: April 2022

AbstractIn response to consumers' growing interest in how products are sourced, produced, and distributed, organizations are increasingly transparent about their supply chain sustainability practices. Supply chain transparency (SCT) efforts are intended to signal positive information about the company to consumers but the benefits are often unclear, especially when consumers receive multiple, but mixed signals that include negative events. We draw on signaling theory to explore how consumers develop impressions of a company's products based on different evaluative dimensions: the positive integrity signal of SCT and the negative capability signal of a product recall. The incongruent signal set creates ambiguity for consumers in assessing product quality and subsequent purchase decisions. We develop two scenario‐based experiments to test aspects of interdimensional signal incongruence. Experiment 1 investigates the magnitude of signal incongruity by considering combinations of different levels of SCT and product recall severity. Experiment 2 investigates the temporal effect of the incongruent signals, considering the restorative effect of SCT after a product recall signal has been received. While product recall signals are salient for consumers in shaping perceptions of product quality and purchase intentions across both experiments, we demonstrate the strategic value of SCT as a positive integrity signal to consumers.
Evaluating habitat selection models to predict critical habitat for mountain goats in northwest British Columbia
Authors: Wolf Jesse F. , MacAulay Kara M. , Kriss Krystal D. 
Published: April 2022

AbstractAnthropogenic activity imposes increasing pressure on wildlife populations globally; these pressures can affect habitat suitability and function, modify wildlife space use, and influence population viability. Native mountain goat (Oreamnos americanus) populations can be negatively affected by anthropogenic disturbance and modify their space use in response to land development and recreational activity. From 2018 to 2020, we studied space use of mountain goats northeast of Smithers, British Columbia, Canada, an area that is subject to increasing anthropogenic development and yearlong recreational activities. We aimed to generate models that would improve our ability to identify habitat for mountain goats relative to existing survey data and established ungulate winter ranges. Using resource selection function (RSF) analyses generated from global positioning system (GPS) collar data, we identified influential habitat covariates and compared these covariates and RSF values to existing habitat models. Additionally, we compared the extent to which our models were congruent with existing resource selection probability functions, were congruent with aerial survey data, and overlapped existing ungulate winter ranges previously derived from predictive models inside and outside of the study area. Overall, our models noted higher RSF values among GPS data relative to aerial survey data for winter months, while results for summer habitats were comparable. In extending our RSFs outside of the study area and evaluating the overlap with ungulate winter ranges in adjacent areas, values were similar, albeit lower, as is expected given that the models were developed elsewhere. Ultimately, these models, combined with existing methods, improve the accuracy and reliability of identified, important areas of habitat for mountain goats. We recommend that the RSF models generated here be used in conjunction with aerial survey data and existing methods to delineate ungulate winter ranges for mountain goats in similar eco‐regions in British Columbia. The models developed here support existing methods that have been used to delineate or validate ungulate winter ranges for mountain goats in British Columbia and help facilitate mitigation measures to support the continued use of important winter habitat and significant landscape features that play a role in ensuring population viability and resilience through time.
SexEst: An open access web application for metric skeletal sex estimation
Authors: Constantinou Chrysovalantis , Nikita Efthymia 
Published: April 2022

AbstractSkeletal sex estimation is an essential step in any osteoarcheological study; hence, several metric and morphological methods have been developed for this purpose, employing different skeletal elements. This paper has a dual purpose: (1) test the performance of several machine learning classification models for skeletal sex estimation using worldwide samples of cranial and postcranial measurements and (2) present a free web application for the implementation of the models that exhibit the highest accuracy so that the sex of unknown skeletons can be straightforwardly estimated. Regarding the first objective, using the Goldman database of postcranial metrics and the William W. Howells craniometric database, machine learning classification models were constructed for sex prediction. The models were optimized with respect to their hyperparameters and cross‐validated reaching accuracies ranging from 80.8%–89.5% for the postcranial data and 81.2%–87.7% for the cranial data. The models offering the highest rates of correct sex classification (Extreme Gradient Boosting, Light Gradient Boosting, and Linear Discriminant Analysis) were then selected to construct an open access and open source web application, SexEst, for predicting the sex of unknown skeletons.
Luminescence imaging of solar modules in full sunlight using ultranarrow bandpass filters
Authors: Rey Germain , Kunz Oliver , Green Martin , Trupke Thorsten 
Published: April 2022

AbstractPhotovoltaic (PV) electricity generation is the fastest growing energy source globally and also humanity's best opportunity to achieve the urgently required deep decarbonisation of the energy sector. As PV enters the terawatt scale, with millions of modules in a single PV power plant, quality testing of installed PV modules becomes indispensable to guarantee PV as a reliable long‐term source of electricity. We present a method that extends the use of photoluminescence (PL) imaging to field‐deployed solar modules in full sunlight. The method takes advantage of sunlight absorption in the Earth's atmosphere in a narrow spectral range around 1,135‐nm wavelength and recent developments in ultranarrow bandpass optical filter technology. The technical principles and experimental data are provided. This method lays the foundations for PL imaging, a powerful inspection method for the PV industry and research, to be applied to routine high‐volume inspection of fielded PV modules on large‐scale solar power plants.
Teaching self‐management strategies to upper‐elementary students: Evidence of promise from the We Have Choices program
Authors: Smolkowski Keith , Marquez Brion , Marquez Jessie , Vincent Claudia , Pennefather Jordan , Walker Hill , Strycker Lisa A. 
Published: April 2022

AbstractStudent behavior problems in general‐education classrooms present a major barrier to effective teaching. Behavior challenges, such as disruptions, noncompliance, and peer conflicts, reduce instructional time, whereas prosocial behaviors, such as paying attention, being ready to work, asking for help, participating in class, and completing homework, improve academic performance. Most interventions developed to address student behavior problems were not designed for general‐education students in typical classrooms. The purpose of this paper is to present preliminary results from a novel intervention developed to enhance behavioral self‐management skills among all upper‐elementary students in general‐education classrooms. We Have Choices, a universal intervention, was designed to increase students' capacity to make appropriate behavioral choices and decrease teachers' responsibility by transferring behavior management to students. An initial randomized controlled trial with 86 fourth‐ to sixth‐grade teachers and 2055 students suggested that We Have Choices was associated with improvements in student‐reported use of self‐management strategies, teacher‐reported student prosocial behavior, and teacher‐reported self‐efficacy in behavior management and instruction. Teachers gave the program high scores for social validity, suggesting a good fit for their classrooms.
Spinal muscular atrophy: Surviving respiratory failure, intensive care and pursuing creatively fulfilled life
Authors: Cheng James W. C. H. , Lai Kwan Yi , Yam Shirley W. L. , Leung Karen K. Y. , Lee Lilian P. Y. , Hon Kam Lun Ellis 
Published: April 2022

AbstractIntroductionSpinal muscular atrophy is a congenital condition associated with mutations in the SMN1 gene. Patients have normal intellectual development, but the natural history is progressive respiratory failure resulting in premature death.CaseDiagnosed with spinal muscular atrophy type 2 in early primary school, the wheelchair‐bound girl developed severe pneumonia on one occasion, when she became critically ill and was admitted to the paediatric intensive care unit with multiorgan dysfunction, requiring mechanical ventilation and high inotropic support. Parents and the patient expressed strong desire for full respiratory and intensive care support to be given. Survived the episode, she is wheelchair ambulatory and continues to pursue a creative artistic career.DiscussionChildren with SMA and their families need to be supported by a comprehensive multi‐disciplinary team to manage this illness. Pediatricians and healthcare givers must provide up‐to‐date health advice on COVID‐19 prophylaxis and management to special groups of patients with respiratory and neurological risks.
Crystalline Covalent Triazine Frameworks with Fibrous Morphology via a Low‐Temperature Polycondensation of Planar Monomer
Authors: Liu Jing , Liu Manying , Wang Xueqing , Wang Xiaoyan , Tan Bien 
Published: April 2022

AbstractThe morphology regulation of covalent triazine frameworks (CTFs) is a great challenge, which may be due to the difficulty in controlling its morphology by traditional synthesis methods. Herein, a general approach to fabricate morphology controllable CTFs by a mild polycondensation reaction in mixed solvents without any templating agents is reported. As a proof of concept, a type of crystalline CTFs with distinctive fibrous morphology (MS‐F‐CTF‐1) (MS: Mixed Solvent; F: Fibrous Morphology) is developed by adjusting the ratio of mixed solvents to control the solubility of monomers, so that the nucleation, crystal growth, and subsequent self‐assembly are controlled, which facilitates the formation of fibrous morphology. The resultant crystalline MS‐F‐CTF‐1 shows uniform fibrous morphology with a diameter of about 100 nm and a length of several micrometers. Notably, the fibrous morphology of CTFs can efficiently improve the photocatalytic hydrogen evolution performance, in which the hydrogen evolution rate can be boosted by about two times in comparison to block ones.
Use of native chicken breeds (Gallus gallus domesticus) for the development of suitable methods of Cantabrian capercaillie (Tetrao urogallus cantabricus) semen cryopreservation
Authors: O'Brien Emma , Castaño Cristina , Toledano‐Díaz Adolfo , Caamaño José Néstor , Hidalgo Carlos , Fidalgo Luis Eusebio , López‐Beceiro Ana María , Esteso Milagros Cristina , Balsera Ramón , García‐Casado Pedro , Łukaszewicz Ewa , Santiago‐Moreno Julián 
Published: April 2022

AbstractBackgroundThe Cantabrian capercaillie (Tetrao urogallus cantabricus) is critically endangered. This subspecies has the lowest genetic variability and it is in regression. It belongs to Phasianidae family; therefore, the domestic chicken (Gallus gallus domesticus) could be a good model for developing reproductive technologies for use in capercaillie populations with low availability of animals.ObjectivesIn this study, we analyzed the response of capercaillie sperm to the freezing–thawing process for contributing to the development of a semen cryobank of Cantabrian capercaillie.MethodsWe used domestic chicken as the animal model in order to obtain the freezing protocol before applying on capercaillie. In the first experiment, two different extenders (EK and LR84) and different concentrations [4% and 6% dimethyl‐acetamide (DMA) v:v] of cryoprotectants were evaluated using in‐straw freezing method in domestic chickens. A pilot study in capercaillie males, using the same conditions evaluated in chicken, was performed.ResultsIn chicken, we found that the LR84‐4% DMA media provided the best results for freezing semen. In capercaillie study, LR84 extender seemed to be the most appropriate diluent and 4% was the better dose of DMA cryoprotectant agent. Further, based on previous studies carried out in rooster samples, we also tested the glycerol (8% v/v) as a cryoprotectant for capercaillie semen cryopreservation.ConclusionsOur results suggest that sperm from both domestic and wild species had a similar response to freezing–thawing processes. Mediterranean chickens may be used as a suitable model for developing sperm freezing protocols that can be extrapolated to threatened capercaillie populations. In addition, LR84 media with glycerol was the most efficient extender to freeze capercaillie sperm native.
A Versatile Route To Cyclic (Alkyl)(Amino)Carbene‐Stabilized Stibinidenes
Authors: Philipp Michael S. M. , Radius Udo 
Published: April 2022

AbstractA convenient route for the synthesis of the cAACMe (cAAC=cyclic (alkyl)(amino)carbene, cAACMe=1‐(2,6‐di‐iso‐propylphenyl)‐3,3,5,5‐tetramethyl‐pyrrolidin‐2‐ylidene) and cAACCy (cAACCy=2‐azaspiro[4.5]dec‐2‐(2,6‐diisopropylphenyl)‐3,3‐dimethyl‐1‐ylidene) stabilized stibinidenes cAACMe⋅SbMes (2 a) (Mes=2,4,6‐trimethylphenyl) and cAACCy⋅SbMes (2 b) is reported. A mechanism for the formation of [cAACRCl][SbCl3Mes] 1 and cAACR⋅SbMes 2 from the reaction of cAAC with the antimony(III) precursor SbCl2Mes, which proceeds via the isolable intermediate [cAACRSbClMes][SbCl3Mes] (3), is proposed.