bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment with biological therapy is associated with faster recovery and lower frequency of treatment switch among rheumatic patients with Chikungunya fever
Authors: Ranzolin Aline , Marques Claudia Diniz Lopes , da Rocha Junior Laurindo Ferreira , Duarte Angela Luzia Branco Pinto , de Lima Hugo Deleon , de Almeida Martins Lays Miranda , de Almeida Anderson Rodrigues , de Oliveira Priscilla Stela Santana , de Melo Rêgo Moacyr Jesus Barreto , da Rocha Pitta Maira Galdino , Bredemeier Markus , Laurindo Ieda Maria Magalhães 
Published: November 2022

Abstract
Background/Objective
The effects of Chikungunya virus (CHIKV) infection on patients with rheumatic diseases have not been extensively studied. Our aim was to compare the clinical course of patients with rheumatoid arthritis and spondyloarthritis, categorized according to the use or not of biologic disease modifying anti-rheumatic drugs (bDMARDs), during and after infection by CHIKV.

Methods
Patients from a northeastern Brazilian city that suffered an epidemic outbreak of Chikungunya fever (CHIK) between Oct 2015 and Jul 2016, on regular follow-up in a longitudinal registry of rheumatic patients (BiobadaBrasil), were invited to participate. Participants underwent a standardized clinical interview and collection of blood sample for serological tests (IgM/IgG) for CHIKV. A positive IgG was considered evidence of previous CHIKV infection.

Results
105 patients (84 with rheumatoid arthritis, 17 with ankylosing spondylitis, and 4 with psoriatic arthritis) were evaluated. Most patients (58, 55.2%) were on therapy with bDMARDs. The overall prevalence of seropositivity for CHIKV was 47.6% (39.7% in patients on bDMARDs and 57.4% in those exclusively on conventional synthetic (cs-) DMARDs (p = 0.070). Among seropositive patients, asymptomatic disease had similar frequency in those treated and not treated with bDMARDs (39.1% versus 33.3%, respectively; p = 0.670). However, patients exclusively on csDMARDs presented significantly higher prevalence of articular symptoms beyond 3 months and switched treatment more often than patients on bDMARDs (p < 0.05 for both comparisons).

Conclusions
Among rheumatic patients with CHIK, those on bDMARDs had shorter persistence of articular symptoms and switched treatment scheme less often than patients exclusively treated with csDMARDs.
Psychiatric morbidity and quality of life in infertile females: a cross-sectional, case-controlled hospital-based study
Authors: Dar Mansoor Ahmad , Shah Seema Batool , Ahmad Syed Nawaz , Shora Tajali Nazir , Kumari Pinki , Tailie Junaid Ahmad 
Published: November 2022

Abstract
Background
Infertility is a huge global problem with a significant mental health burden. Infertility could become a source of continuous stress leading to psychosocial issues including stress, anxiety, depression, and low self-esteem in these women. A cross-sectional, case-controlled study was conducted between January 2021 and November 2021 to study the effect of infertility on mental health and quality of life. A semi-structured questionnaire was used for sociodemographic and clinical variables. The Oslo Social Support Scale-3 and FertiQol were used to study social support and quality of life respectively. Psychiatric morbidity was assessed using ICD-10 symptom checklist. A total of 56 cases and 102 controls were studied.

Results
The mean age of cases and controls was 30.4 ± 3.5 years and 31.9 ± 2.9 years, respectively. Young infertile females, primary infertility, and female factor for infertility were associated with higher psychiatric morbidity. Psychiatric morbidity was seen in 46.4% of infertile women. FertiQoL score for the infertile group was 64.61 ± 5 with the lowest score in the emotional domain (45.10) and mind-body domain (54.86) (p < 0.0001). The scores in the relational domain and social domain were higher (85.2 and 73.3, respectively). The scores in the mind-body domain and emotional domain were poor among the infertile women regardless of the presence of psychiatric morbidity (48.27 vs 59.80 and 43.57 vs 46.57) (p < 0.0001–0.04).

Conclusions
Our study emphasizes the role of more qualitative instruments like FertiQoL in studying the well-being of infertile women. Even in the absence of psychiatric morbidity, the QoL score could still predict mental well-being in fertility-related issues.
Evaluation of molecular signatures in the urinary bladder and upper tract urothelial carcinomas: a prospective controlled clinical study
Authors: Dawood Eman E. , Awadalla Amira , Hashem Abdelwahab , Shokeir Ahmed A. , Abdel-Aziz A. F. 
Published: November 2022

Abstract
Background
Urothelial carcinomas (UC) can be either in the upper or in the lower urinary tract or both. Urothelial bladder cancer (UBC) is more common than upper tract urothelial carcinoma (UTUC). This research was designed to study the difference between UBC and UTUC using the molecular pathways including (MAPK/ERK) pathway, cell cycle regulating genes, and oncogenic genes.

Methods
To study the discrepancy between UBC and UTUC, a prospective trial was carried out for 31 radical cystectomy and 19 nephrouretrectomy fresh-frozen specimens of UBC and UTUC patients, respectively. The expression level of mRNA of eight genes namely EGFR, ELK1, c-fos, survivin, TP53, RB1, FGFR3, and hTERT was assessed in normal adjacent tissues, UTUC, and UBC by RT-PCR.

Results
Comparison between UTUC and UBC regarding the expression level of mRNA of the EGFR, ELK1, c-fos, survivin, TP53, and FGFR3 had significant difference (p-value < 0.001), while the expression level of RB1 and hTERT level had no significance. Sensitivity/specificity of EGFR, Elk1, c-fos, survivin, TP53, and FGFR3 was 0.78/0.90, 0.84/0.90, 0.84/0.80, 0.84/0.96, 0.94/0.93, and 0.89/0.93, respectively, to differentiate between UTUC and UBC.

Conclusions
Despite the fact that UTUC and UBC share the same origin, there is a clear evidence that there is a molecular difference between them. This molecular difference could be the reason that UTUC is more aggressive than UBC.
Efficacy and Safety of Trametinib Monotherapy or in Combination With Dabrafenib in Pediatric BRAF V600–Mutant Low-Grade Glioma
Authors: Bouffet Eric , Geoerger Birgit , Moertel Christopher , Whitlock James A. , Aerts Isabelle , Hargrave Darren , Osterloh Lisa , Tan Eugene , Choi Jeea , Russo Mark , Fox Elizabeth 
Published: November 2022

PURPOSE BRAF V600 mutations occur in many childhood cancers, including approximately 20% of low-grade gliomas (LGGs). Here, we describe a phase I/II study establishing pediatric dosing and pharmacokinetics of trametinib with or without dabrafenib, as well as efficacy and safety in a disease-specific cohort with BRAF V600–mutant LGG; other cohorts will be reported elsewhere. METHODS This is a four-part, phase I/II study (ClinicalTrials.gov identifier: NCT02124772 ) in patients age < 18 years with relapsed/refractory malignancies: trametinib monotherapy dose finding (part A) and disease-specific expansion (part B), and dabrafenib + trametinib dose finding (part C) and disease-specific expansion (part D). The primary objective assessed in all patients in parts A and C was to determine pediatric dosing on the basis of steady-state pharmacokinetics. Disease-specific efficacy and safety (across parts A-D) were secondary objectives. RESULTS Overall, 139 patients received trametinib (n = 91) or dabrafenib + trametinib (n = 48). Trametinib dose-limiting toxicities in > 1 patient (part A) included mucosal inflammation (n = 3) and hyponatremia (n = 2). There were no dose-limiting toxicities with combination therapy (part C). The recommended phase II dose of trametinib, with or without dabrafenib, was 0.032 mg/kg once daily for patients age < 6 years and 0.025 mg/kg once daily for patients age ≥ 6 years; dabrafenib dosing in the combination was as previously identified for monotherapy. In 49 patients with BRAF V600–mutant glioma (LGG, n = 47) across all four study parts, independently assessed objective response rates were 15% (95% CI, 1.9 to 45.4) for monotherapy (n = 13) and 25% (95% CI, 12.1 to 42.2) for combination (n = 36). Adverse event–related treatment discontinuations were more common with monotherapy (54% v 22%). CONCLUSION The trial design provided efficient evaluation of pediatric dosing, safety, and efficacy of single-agent and combination targeted therapy. Age-based and weight-based dosing of trametinib with or without dabrafenib achieved target concentrations with manageable safety and demonstrated clinical efficacy and tolerability in BRAF V600–mutant LGG.
Clinical Impact of ASCO Choosing Wisely Guidelines on Staging Imaging for Early-Stage Breast Cancers: A Time Series Analysis Using SEER-Medicare Data
Authors: Baltz Alan P. , Siegel Eric R. , Kamal Arif H. , Siegel Robert , Kozlik Mary May , Crist Stéphanie T. S. , Makhoul Issam ,   on behalf of the ASCO Quality Publications Task Force
Published: November 2022

PURPOSE: American Society for Clinical Oncology released the Choosing Wisely list in 2012, highlighting low-value procedures that lack evidence, advising against the use of positron emission tomography, computerized tomography, and radionuclide bone scans for the staging of early-stage breast cancer at low risk for metastasis. The objective of the study was to assess the impact of the American Society of Clinical Oncology Choosing Wisely guidelines on inappropriate staging imaging among early-stage breast cancers. METHODS: The Surveillance, Epidemiology, and End Results Program-Medicare data set was used to identify 50,004 women age 66 years and older with new incident diagnosis of early-stage breast cancer (stage 0 through stage 2a; T < 4, N = 0, and M = 0). The primary outcome was the incidence of patients with inappropriate imaging following an early-stage breast cancer diagnosis. The primary outcome was identified within 6 months of the first diagnosis. An interrupted time series analysis using negative binomial regression was performed for outpatient claims for these diagnostic studies versus the two interruptions of guidelines release and guidelines reinforcement. Mean images per patient, percent change for the study period, and rate of change per year were calculated. RESULTS: Imaging rates fell by a modest 2.32% following guidelines release in April 2012 (point estimate = −2.32%; 95% CI, −6.34% to 1.88%). By contrast, imaging rates fell by a four-fold larger amount (point estimate = −9.36%; 95% CI, −13.20% to −5.35%) following guidelines published reminders in journals (or reinforcement) in October 2013. Mean imaging studies per patient (95% CI) declined from 1.80 (1.76 to 1.84) in January 2012 to 1.50 (1.48 to 1.53) by January 2015, representing a 16% decline in imaging overuse in 2015 compared with 3 years earlier. The rate of change (95% CI) in images per patient was initially small at −0.47% (−4.27% to 3.33%) per year between April 2012 and October 2013, but almost eight times faster at −3.70% (−5.81% to −1.60%) per year after October 2013. CONCLUSION: This analysis demonstrates a substantial decrease in the prevalence of imaging overuse in early-stage breast cancers correlating with the 2013 reinforcement of American Society of Clinical Oncology's 2012 Choosing Wisely guidelines. The creation and dissemination of such resources serves as a powerful tool to improve clinical practice, cost-effectiveness, and patient safety from secondary malignancies, anxiety, and overdiagnosis.
Statistics of phase fluctuations of an acoustic wave propagating through a turbulent flow
Authors: Prabhudesai G. , Perrard S. , Pétrélis F. , Fauve S. 
Published: November 2022

Abstract
We investigate the statistics of phase fluctuations of an acoustic wave propagating through a turbulent flow in line of sight (LOS) configuration. Experiments are performed on a closed von Kármán swirling flow whose boundaries are maintained at a constant temperature. In particular, we analyze the root mean square (RMS) and the power spectrum density (PSD) of phase fluctuations. A model is developed and analytical predictions obtained for these quantities using geometrical acoustics are shown to be in agreement with experimental observations.
Sinicizing European Languages: Lexicographical and Literary Practices of Pidgin English in Nineteenth-Century China
Authors: Liu Yuqing 
Published: November 2022

AbstractThis article reconsiders the social, economic, and literary significance of Chinese Pidgin English (CPE) in Chinese society by exploring lexicographical and literary practices of pidgin in nineteenth-century China. Resituating the history of CPE in Chinese language history, this article problematizes the concept of pidgin and pursues three arguments. First, the author maintains that CPE arose from the marginalized status of the Euro-American traders who were restricted from learning the Chinese language in Canton. Second, by exploring foreign-language glossaries, this article foregrounds the key role of sinographs and Chinese topolects in mediating and remolding foreign languages. Last, by examining the appropriation of foreign sounds in Cantonese folk songs and Pan Youdu's poetry, this article demonstrates the complex flow of these sounds among different languages and the power of pidgin in transgressing linguistic boundaries.
Localism of Daoxue in North China during the Yuan Dynasty: A Case Study of An Xi (1270–1311)
Authors: Koh Khee Heong 
Published: November 2022

AbstractThe transmission of Daoxue, or Neo-Confucianism, during the Yuan Dynasty cannot be understood as a sharp dichotomy between reliance on state-sponsored institutions in North China and private ones in the south. Through the study of An Xi, who was a student and teacher of Daoxue, and his family from modern day Hebei, this article shows that private intellectual activities of Yuan Daoxue masters were influential locally in the north. Although An Xi has traditionally been recognized as a member of the Daoxue scholar Liu Yin's tradition, this article further argues that An Xi developed his own independent thinking and was not simply a follower of Liu Yin. An Xi was a self-taught Daoxue master who idolized Zhu Xi and took his teaching as the only standard. This self-taught model would later become more common in North China during the Ming Dynasty.
Ts66Yah, a mouse model of Down syndrome with improved construct and face validity
Authors: Duchon Arnaud , del Mar Muñiz Moreno Maria , Chevalier Claire , Nalesso Valérie , Andre Philippe , Fructuoso-Castellar Marta , Mondino Mary , Po Chrystelle , Noblet Vincent , Birling Marie-Christine , Potier Marie-Claude , Herault Yann 
Published: November 2022

ABSTRACT
Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). The understanding of genotype–phenotype relationships, the identification of driver genes and various proofs of concept for therapeutics have benefited from mouse models. The premier model, named Ts(1716)65Dn/J (Ts65Dn), displayed phenotypes related to human DS features. It carries an additional minichromosome with the Mir155 to Zbtb21 region of mouse chromosome 16, homologous to Hsa21, encompassing around 90 genes, fused to the centromeric part of mouse chromosome 17 from Pisd-ps2/Scaf8 to Pde10a, containing 46 genes not related to Hsa21. Here, we report the investigation of a new model, Ts66Yah, generated by CRISPR/Cas9 without the genomic region unrelated to Hsa21 on the minichromosome. As expected, Ts66Yah replicated DS cognitive features. However, certain phenotypes related to increased activity, spatial learning and molecular signatures were changed, suggesting genetic interactions between the Mir155-Zbtb21 and Scaf8-Pde10a intervals. Thus, Ts66Yah mice have stronger construct and face validity than Ts65Dn mice for mimicking consequences of DS genetic overdosage. Furthermore, this study is the first to demonstrate genetic interactions between triplicated regions homologous to Hsa21 and others unrelated to Hsa21.
This article has an associated First Person interview with the first author of the paper.
17q12 deletion syndrome mouse model shows defects in craniofacial, brain and kidney development, and glucose homeostasis
Authors: Warren Emily B. , Briano Juan A. , Ellegood Jacob , DeYoung Taylor , Lerch Jason P. , Morrow Eric M. 
Published: November 2022

ABSTRACT
17q12 deletion (17q12Del) syndrome is a copy number variant (CNV) disorder associated with neurodevelopmental disorders and renal cysts and diabetes syndrome (RCAD). Using CRISPR/Cas9 genome editing, we generated a mouse model of 17q12Del syndrome on both inbred (C57BL/6N) and outbred (CD-1) genetic backgrounds. On C57BL/6N, the 17q12Del mice had severe head development defects, potentially mediated by haploinsufficiency of Lhx1, a gene within the interval that controls head development. Phenotypes included brain malformations, particularly disruption of the telencephalon and craniofacial defects. On the CD-1 background, the 17q12Del mice survived to adulthood and showed milder craniofacial and brain abnormalities. We report postnatal brain defects using automated magnetic resonance imaging-based morphometry. In addition, we demonstrate renal and blood glucose abnormalities relevant to RCAD. On both genetic backgrounds, we found sex-specific presentations, with male 17q12Del mice exhibiting higher penetrance and more severe phenotypes. Results from these experiments pinpoint specific developmental defects and pathways that guide clinical studies and a mechanistic understanding of the human 17q12Del syndrome. This mouse mutant represents the first and only experimental model to date for the 17q12 CNV disorder.
This article has an associated First Person interview with the first author of the paper.
Reporting Attendance and Resistance Exercise Compliance in Men with Localized Prostate Cancer
Authors: LOPEZ PEDRO , TAAFFE DENNIS R. , NEWTON ROBERT U. , SPRY NIGEL , JOSEPH DAVID , TANG COLIN , BUFFART LAURIEN M. , GALVÃO DANIEL A. 
Published: November 2022

ABSTRACT

Purpose
Resistance exercise is a well-established intervention to counteract musculoskeletal and metabolic toxicities from prostate cancer treatment. In this study, we reported resistance exercise attendance and compliance, and examined if these variables can influence changes in outcomes of interest in men with localized or locally advanced prostate cancer.

Methods
A total of 83 prostate cancer patients (age, 68.2 ± 7.0 yr; body mass index, 27.7 ± 3.8 kg·m−2) who had undergone 6 months of resistance-based exercise and had data available on exercise training from logbook records were examined. Attendance outcomes such as missed sessions, interruptions and permanent discontinuation, and metrics such as dosage completed (sessions × number of exercises × sets × repetitions × external load), compliance, tolerance, reductions, and escalations were assessed. Outcomes assessed were body composition, physical function, and muscle strength.

Results
Median resistance exercise attendance was 80.6%, with a median resistance exercise compliance of 88.5% (interquartile range [IQR], 61.1%–107.1%) per participant. A median of 11 (IQR, 1–26) and 0 (IQR, 0–2) sessions were escalated or reduced, respectively. Significant improvements were observed in whole-body lean mass, 400-m walk, repeated chair rise, leg press, and chest press strength after 6 months of intervention (P < 0.05) regardless of resistance exercise compliance (P
trend = 0.199–0.950). Participants with higher levels of resistance exercise compliance presented greater improvements in trunk fat mass (P
trend = 0.026) and appendicular lean mass (P
trend = 0.047).

Conclusions
A higher resistance exercise compliance led to greater improvements in regional fat and lean mass, whereas physical function and muscle strength improvements were achieved with lower compliance. In addition, patients experienced a high number of dose escalations during the intervention. These findings are important to improve the reproducibility/precision of exercise medicine prescription.
Case Report: Takotsubo syndrome in a postoperative patient without cardiological disease
Authors: Coaguila-Cusicanqui Luis , Castillo-Atoche Vanessa , Montalvo-Suyon Roberto , Cavero-Reyes Yuriko , Failoc-Rojas Virgilio E. 
Published: November 2022

Background: Takotsubo syndrome (TS) is characterized by a clinical presentation that mimics acute coronary syndrome but is reversible. Alterations of Takotsubo in patients without previous heart disease remain a challenge for diagnosis. Case report: We present a case of an 80-year-old patient from Peru. The patient underwent surgery, with the diagnosis of Chilaiditi’s syndrome. One day after surgery, she presented with dyspnea, tachycardia, and electrocardiographic changes (paroxysmal atrial fibrillation and infrequent ventricular extrasystoles without abnormalities in the ST-segment). The diagnosis of Takotsubo syndrome with cardiogenic shock was made. She was hospitalized in the Intensive Care Unit and was managed with vasopressors and nitroglycerin. There was no cardiac lesion in the cineangiogram or occlusion of arteries. The patient was extubated and received daily dialysis until discharge. Conclusions: Takotsubo is an emotional, non-cardiac, or post-traumatic stressful event that triggers myocardial injury with segmental anomalous, the possible etiology of which is the release of an endothelial neurotransmitter caused by stress. Emergency physicians should be aware of this as even patients without previous cardiac pathologies when exposed to stressors (such as surgeries) develop emergency symptomatology similar to myocardial infarction. Thus, emergency physicians should identify any cardiac abnormalities after a stressor, as well as be prepared for the diagnosis of TS.