bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food inauthenticity: Authority activities, guidance for food operators, and mitigation tools
Authors: Popping Bert , Buck Neil , Bánáti Diána , Brereton Paul , Gendel Steven , Hristozova Nevena , Chaves Sandra Mourinha , Saner Samim , Spink John , Willis Charon , Wunderlin Daniel 
Published: October 2022

AbstractHistorically, food fraud was a major public health concern which helped drive the development of early food regulations in many markets including the US and EU market. In the past 10 years, the integrity of food chains with respect to food fraud has again been questioned due to high profile food fraud cases. We provide an overview of the resulting numerous authoritative activities underway within different regions to counter food fraud, and we describe the guidance available to the industry to understand how to assess the vulnerability of their businesses and implement appropriate mitigation. We describe how such controls should be an extension of those already in place to manage wider aspects of food authenticity, and we provide an overview of relevant analytical tools available to food operators and authorities to protect supply chains.Practical Application: Practical Application of the provided information by the food industry in selecting resources (guidance document, analytical methods etc.)
Effect of time to pre‐emptive transjugular intrahepatic portosystemic shunt on patient outcome, a UK multicentre cohort study
Authors: Dunne Philip , Finkel Jemima , Khan Faisal , Lachlan Neil , Patch David , Tripathi Dhiraj , Stanley Adrian , Hayes Peter 
Published: October 2022

SummaryBackgroundPre‐emptive transjugular intrahepatic portosystemic shunt (pTIPSS) should be considered within 72 hours following acute oesophageal variceal bleeding. However, recent studies highlight the difficulty in providing pTIPSS within this narrow timeframe. Delaying pTIPSS beyond 72 hours has not been studied.AimTo determine if the time taken to perform pTIPSS alters patient outcome.MethodPatients referred to 4 UK tertiary centres for pTIPSS between 01 January 2010 and 31 December 2018 were included. Time from endoscopy to pTIPSS was recorded and pre‐defined clinically relevant outcomes were observed relative to two groups: early pTIPSS (<72 h) and late pTIPSS (72 h–28 days). The primary outcome was transplant‐free survival at 1‐year. Follow‐up was until 31 December 2020.ResultsA total of 83 patients received early pTIPSS and 88 received late pTIPSS. Baseline characteristics were similar with no requirement for propensity score‐matched analysis. There was no difference between early and late pTIPSS groups for patient outcomes; 1‐year transplant‐free survival rate (69.9% vs 71.6%, p = 0.73, HR 0.91, 95% CI 0.52–1.58), long‐term survival (p = 0.52, HR 1.132, 95% CI 0.77–1.65), variceal rebleeding (4.82% vs 11.36%, p = 0.09, HR 0.411, 95% CI 0.14–1.17), hepatic encephalopathy (43.93% vs 34.61%, p = 0.26) and new or worsening ascites (16.6% vs 13.46%, p = 0.79). Death due to liver failure was significantly more prevalent in those undergoing early pTIPSS compared to late pTIPSS (44% vs 16%, p = 0.046, HR 2.79, 95%CI 1.02–8.32).ConclusionPlacement of pTIPSS within 72 hours offered similar short‐ and long‐term survival benefits compared to pTIPSS placed between 72 hours and 28 days. Early pTIPSS may be associated with an increased risk of liver failure‐related mortality. Further large, randomised studies are required to evaluate these findings.
What silence suggests: Thoughts from a moment in a Greater Manchester café
Authors: Barron Amy 
Published: October 2022

AbstractThis paper considers what silences might suggest during research conversations. Reflecting on an interaction in a café, I show how silences might be thought of as ‘interruptions’: important moments in which streams of experience are disrupted and when processes of sense making occur. Though there is no ‘one‐size‐fits‐all’ approach to how researchers should deal with silences, the skilled researcher might be one who recognises that what a silence is and how it should be dealt with depends upon context. Researchers need to think more about silences rather than removing these kinds of detail in favour of neat narratives.
Haploidentical transplant for paediatric patients with severe thalassaemia using post‐transplant cyclophosphamide and methotrexate: A prospectively registered multicentre trial from the Bone Marrow Failure Working Group of Hunan Province, China
Authors: Hu Jian , Gong Susu , Chen Keke , Yang Rui , Wang Leyuan , Yang Kaitai , Nie Lin , Zou Lang , Su Tao , Chen Cong , Xu Yajing , He Xianglin , Yang Liangchun , Xiao Hong , Fu Bin 
Published: October 2022

SummaryHaploidentical transplantation strategies for patients with transfusion‐dependent thalassaemia (TD‐TM) remain to be investigated. In this study, 54 paediatric patients with TD‐TM were treated with a novel approach using post‐transplant cyclophosphamide (PTCy) and low‐dose methotrexate (LD‐MTX), following a myeloablative regimen. The incidence of neutrophil and platelet engraftment was 96.3% ± 2.6% and 94.4% ± 3.1% respectively. The cumulative incidence of grades II–III acute graft‐versus‐host disease (GVHD) was 13.8% ± 4.8% at 100 days. At three years, the cumulative incidence of chronic GVHD was 28.5% ± 8.5%. With a median follow‐up of 520 days (132–1325 days), the overall survival (OS) and event‐free survival (EFS) were 98.1% ± 1.8% and 90.7% ± 3.9% respectively. Compared with the low‐dose cyclophosphamide (CTX) conditioning regimen (120 mg/kg), the high‐CTX regimen (200 mg/kg) achieved a higher incidence of stable engraftment (100% vs 66.7% ± 15.7%, p = 0.003), a comparable incidence of grades II–III acute GVHD, a lower incidence of chronic GVHD (20.2% ± 8.3% vs 66.6% ± 19.2%, p = 0.011), and better overall survival (100% vs 88.9% ± 10.5%, p = 0.025) as well as EFS (95.6% ± 3.1% vs 66.7% ± 15.7%, p = 0.008). Our results using unmanipulated haploidentical grafts and PTCy with LD‐MTX in TD‐TM are encouraging. (chictr.org.cn ChiCTR1800017969)
‘Depending on where I am…’ Hair, travelling and the performance of identity among Black and mixed‐race women
Authors: Lukate Johanna M. , Foster Juliet L. 
Published: October 2022

AbstractA growing interdisciplinary literature examines the role of hair textures and styles in Black and mixed‐race women's identity performances. Through an analysis of travel narratives, this paper extends and complements research on the context‐dependency of racialized identity performances. This paper presents an analysis of 24 qualitative interviews with Black and mixed‐race women in England and Germany. The question it seeks to answer is: ‘How do changes in context alter Black and mixed‐race women's hairstyling practices as a performance of identity?’ Navigating a novel context could lead the women to (1) conform to local standards of beauty and femininity, (2) resist external expectations, (3) try out novel performances and (4) negotiate the complex performance of belonging. All in all, this paper shows that Black and mixed‐race women dialogically re/negotiated and performatively re/created how they identify and how they are identified by others as they moved from one context to another.
Tuberous xanthoma secondary to homozygous familial hypercholesterolaemia: a life-threatening diagnosis
Authors: Kazmi Ahmed , Frewen John , McDonald Bryan , Davison James , O'Toole Edel 
Published: October 2022

Abstract
We report the case of a 9-year-old girl who presented with asymptomatic lesions on the extensor surfaces of the elbows and knees, in keeping with tuberous xanthoma. She was investigated and diagnosed with homozygous familial hypercholesterolaemia, and commenced on lipid-lowering treatment. We highlight the importance of identification of this condition early, such that life-saving treatment can be initiated and premature death avoided.
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Cinnamon essential oil liposomes modified by sodium alginate‐chitosan: application in chilled pork preservation
Authors: Tu Qian , Li Shanshan , Zeng Zhen , Liu Yuntao , Wang Caixia , Chen Saiyan , Hu Bin , Li Cheng 
Published: October 2022

SummaryIn this study, cinnamon essential oil liposomes (CEO‐Lip), chitosan (CH) modified CEO‐Lip (CH‐CEO‐Lip) and sodium alginate (SA) and CH modified CEO‐Lip (SA‐CH‐CEO‐Lip) were prepared based on layer‐by‐layer electrostatic self‐assembly deposition technique and their preservative effects on fresh pork were investigated. The average particle size of SA‐CH‐CEO‐Lip was 178.73 nm with polymer dispersity index (PDI) of 0.380, zeta potential of −23.83 mV. Results showed that the formation of SA‐CH‐CEO‐Lip was efficient (encapsulation efficiency 89.5%). Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) confirmed that SA‐CH‐CEO‐Lip was prepared successfully. The in vitro cumulative release study during 72 h revealed that SA‐CH‐CEO‐Lip (71.42%) showed better sustained release capability than CEO‐Lip (81.24%). The pork assessment test showed that SA‐CH‐CEO‐Lip could effectively inhibit the increase in pH, total volatile basic nitrogen (TVB‐N) and thiobarbituric acid reactants (TBARS) of pork compared with CEO‐Lip group (P < 0.05). The total number of colonies (TBC) showed that the storage life of SA‐CH‐CEO‐Lip group could be extended to 12 days, which was significantly different from that of control group (6 days) (P < 0.05). In addition, SA‐CH‐CEO‐Lip also effectively maintained the good sensory quality of pork. In conclusion, SA‐CH‐CEO‐Lip showed good antiseptic effects on chilled pork preservation.
Determination of bruise preventing capacity of the cushioning material in persimmon fruit under pendulum impact test
Authors: Yeşiloğlu Cevher Elçin 
Published: October 2022

AbstractFruits, essential in human nutrition, go through many stages until they reach the consumption stage. Brıise may occur on the fruit during loading, unloading, and processing. One of the options applied to prevent bruises to fruits throughout the supply chain is to package cushioning materials. This study investigated the number of bruises caused by applying impact energies to the covered and uncoated (bare) persimmon fruits with foam net material. Impact energy applications were carried out with the developed pendulum impact test setup. Dynamic loadings at different impact energy levels, low (0.03 J), medium (0.06 J), and high energy (0.11 J) were applied to three other regions of persimmon fruits (blossom side, lateral diameter, and stem side). Statistical analysis showed that the effect of impact energy on bruise volume was significant (p ˂ 0.01). The study found a linear relationship between bruising volume on persimmons and impact energy. According to the experiment results, it was determined that the bruise volume values of persimmons with foam net used as cushioning material were significantly less than the bare persimmons. As a result of the applied impact energies, it was determined that the average bruise volume of the persimmons was 225.74 mm3 in the bare ones and 21.29 mm3 in the ones covered with foam net. It was also revealed that the blossom side of the persimmon was the most sensitive to impact energy, and the lateral diameter side was the most durable.Practical ApplicationsMechanical bruises to fruits and vegetables during post‐harvest processing can be significant. Bruise‐sensitive fruits such as persimmon increase the size of bruises due to falling from height during filling and unloading. Understanding where and how large the bruising effects caused by impact energies are can help reduce fruit bruises. Packaging practices, which are ways to prevent fruit bruising, play an important role in prolonging the shelf life of the fruit and reducing the risk of physical bruising. In the study, the effect of the cushioning material on the prevention of the size of bruises caused by the impact energy effect on the persimmon fruit was investigated. It is aimed to compare the bruise amount of foam‐coated and non‐foam‐coated persimmon fruits by considering the fruit regions in the applications performed with the pendulum test setup.
Climate change impacts on flood peaks in Britain for a range of global mean surface temperature changes
Authors: Rudd Alison C. , Kay Alison L. , Sayers Paul B. 
Published: October 2022

AbstractAn increase in extreme weather events is leading to increased flood occurrence and risk in many areas. Although climate mitigation strategies are being implemented, it is widely accepted that societies must adapt to climate variability and climate change. Traditional climate change impact studies have used projections for future time‐slices, often for a range of possible emissions scenarios. Recently however, there has been a move to instead consider climate change impacts relative to global mean surface temperature (GMST) change, to try to encourage action to avoid the more severe impacts from higher GMST changes. To support adaptation planning, more localised information on impacts is required. Here, data on the potential range of changes in flood peaks is generated by combining flood response surfaces and the new UK Climate Projections 2018, for every river cell on a 1 km grid across Britain, for GMST changes of 1–4.5°C. The results show significant spatial variation, with impacts typically higher in the west than the east, and generally increasing with GMST change. Some southern regions show flood peak changes accelerating with GMST change. The changes in flood peaks can be translated into changes in flood inundation and associated flood risk under alternative adaptation assumptions.
Age‐friendly care in the Veterans Health Administration: Past, present, and future
Authors: Farrell Timothy W. , Volden Tiffany A. , Butler Jorie M. , Eleazer G. Paul , Rupper Randall W. , Echt Katharina V. , Shaughnessy Marianne , Supiano Mark A. 
Published: October 2022

AbstractThe Veterans Health Administration (VHA) has long recognized the need for age‐friendly care. VHA leadership anticipated the impact of aging World War II veterans on VA healthcare systems and in 1975 developed Geriatric Research, Education, and Clinical Centers (GRECCs) to meet this need. GRECCs catalyzed a series of innovations in geriatric models of care that span the continuum of care, most of which endure. These innovative care models also contributed to the evidence base supporting the present‐day Age‐Friendly Health Systems movement, with which VHA is inherently aligned. As both a provider of and payor for care, VHA is strongly incentivized to promote coordination across the continuum of care, with resultant cost savings. VHA is also a major contributor to developing the workforce that is essential for the provision of age‐friendly care. As VHA continues to develop and refine innovative geriatric models of care, policymakers and non‐VHA health care systems should look to VHA programs as exemplars for the development and implementation of age‐friendly care.
Liquidity, the Mundell–Tobin Effect, and the Friedman Rule
Authors: ALTERMATT LUKAS , WIPF CHRISTIAN 
Published: October 2022

AbstractWe investigate how a positive relation between inflation and capital investment (the Mundell–Tobin effect, MT‐E) affects optimal monetary policy in a framework that combines overlapping generations and new Monetarist models. We find that inflation rates above the Friedman rule are optimal if and only if there is an MT‐E. In the absence of the MT‐E, the Friedman rule is optimal. With an MT‐E, increasing inflation above the Friedman rule leads to a first‐order welfare gain from increasing capital investment, and only to a second‐order welfare loss from reducing consumption in markets where liquidity matters.
Maternal cardiopulmonary resuscitation
Authors: Tanaka Hiroaki , Matsunaga Shigetaka , Furuta Marie , Kato Rie , Takahashi Shinji , Takeda Jun , Nakao Masahiro , Nakamura Eishin , Nii Masafumi , Yamashita Tomoyuki , Yamahata Yoshihiro , Enomoto Naosuke , Tsuji Makoto , Baba Shiniji , Hosokawa Yuki , Maenaka Takahide , Sakurai Atsushi 
Published: October 2022

AbstractThe perinatal resuscitation history in Japan is short, with the earliest efforts in the field of neonatology. In contrast, the standardization and dissemination of maternal resuscitation is lagging. With the establishment of the Maternal Death Reporting Project and the Maternal Death Case Review and Evaluation Committee in 2010, with the aim of reducing maternal deaths, the true situation of maternal deaths came to light. Subsequently, in 2015, the Japan Council for the Dissemination of Maternal Emergency Life Support Systems (J‐CIMELS) was established to educate and disseminate simulations in maternal emergency care; training sessions on maternal resuscitation are now conducted in all prefectures. Since the launch of the project and council, the maternal mortality rate in Japan (especially due to obstetric critical hemorrhage) has gradually decreased. This has been probably achieved due to the tireless efforts of medical personnel involved in perinatal care, as well as the various activities conducted so far. However, there are no standardized guidelines for maternal resuscitation yet. Therefore, a committee was set up within the Japan Resuscitation Council to develop a maternal resuscitation protocol, and the Guidelines for Maternal Resuscitation 2020 was created in 2021. These guidelines are expected to make the use of high‐quality resuscitation methods more widespread than ever before. This presentation will provide an overview of the Guidelines for Maternal Resuscitation 2020.
Colitis induced by dextran sulphate sodium causes histopathological and immunological changes in the periodontal tissues of Wistar rats
Authors: de Mello‐Neto João Martins , Elangovan Gayathiri , Ervolino Edilson , Johnson Newell Walter , Gustafsson Anders , da Figueredo Carlos Marcelo 
Published: October 2022

AbstractObjectiveThis study investigated the impact of colitis induced by dextran sulphate sodium (DSS)‐induced colitis (DIC) on histopathological and immunological outcomes in the periodontal tissues of Wistar rats.BackgroundInflammatory bowel diseases (IBD) and periodontitis have been reported to present a bidirectional relationship. However, the inflammatory pathway that connects both diseases needs further investigation.Material and MethodsTwenty‐five male Wistar rats were allocated in four groups: unilateral ligature‐induced periodontitis for 14 days: LIP (n = 7); dextran sulphate sodium‐induced colitis only: DIC (n = 6); DIC + LIP (n = 6) and controls (n = 6). Digital images were obtained from the histological sections. In order to assess the attachment loss (AL), the linear distance between the cementoenamel junction (CEJ) and the alveolar bone crest was measured on the mesial root using histological photomicrography's ImageJ software. Immunological analyses of gingival tissues and plasma were performed by Bio‐Plex Th1/Th2 Assay.ResultsThe DIC group showed inflammatory cells extending to the periodontal connective tissues, which contained significantly elevated expressions of IL‐1α, IL‐1β, IL‐2, IL‐6, IL‐12, IL‐13, GM‐CSF, IFN‐γ and TNF‐α compared to controls. There was no significant difference in bone loss between controls and DIC. There were no significant histopathological differences between DIC + LIP and LIP. However, DIC + LIP presented a significantly lower IL‐2 and IL‐5 than the LIP group. There was no bone loss difference between LIP+DIC and LIP groups. DIC + LIP group presented significantly higher levels of GM‐CSF in plasma.ConclusionDSS‐induced colitis was associated with an overexpression of Th1/Th2‐ related cytokines in the gingival tissue.
Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left‐sided congestive heart failure in dogs
Authors: Giorgi Maria E. , Mochel Jonathan P. , Yuan Lingnan , Adin Darcy B. , Ward Jessica L. 
Published: October 2022

AbstractBackgroundKidney injury (KI) has been documented in dogs treated with furosemide for left‐sided congestive heart failure (CHF).Hypothesis/ObjectivesDetermine risk factors for development of KI in furosemide‐treated dogs and determine the effect of KI on survival.AnimalsSeventy‐nine client‐owned dogs receiving parenteral furosemide for CHF.MethodsSerum creatinine (sCr) and electrolyte concentrations were determined during hospitalization and at first outpatient reevaluation to detect and stage KI (increase in sCr ≥0.3 mg/dL). Furosemide dosage administered between timepoints was calculated. Multivariable modeling was performed to identify predictors of KI and percent change in serum biochemistry results over time.ResultsKidney injury was identified in 38/79 (48%) dogs and mostly occurred during hospitalization. Kidney injury was Grade I in 25 dogs, Grade II in 9 dogs, and Grade III in 4 dogs. Higher blood pressure was associated with acute KI during hospitalization (odds ratio, 1.03; 95% confidence interval [95% CI] 1.01‐1.07;P = .03) whereas PO furosemide dosage was associated with KI after hospital discharge (odds ratio, 7.77; 95% CI, 2.05‐68.6;P = .02). Baseline sCr and use of a furosemide continuous rate infusion were not associated with increased risk of KI. Kidney injury was not associated with long‐term outcome. Of 13 dogs with Grade II‐III KI, azotemia was reversible in 9 dogs, and 6 dogs survived >1 year after KI.Conclusions and Clinical ImportanceIn this cohort of dogs receiving parenteral furosemide for CHF, KI was common, mostly nonazotemic (Grade I), and did not impact survival.
A phosphate starvation response‐regulated receptor‐like kinase, OsADK1, is required for mycorrhizal symbiosis and phosphate starvation responses
Authors: Shi Jincai , Zhao Boyu , Jin Rui , Hou Ling , Zhang Xiaowei , Dai Huiling , Yu Nan , Wang Ertao 
Published: October 2022

Summary

Most land plants associate with arbuscular mycorrhizal (AM) fungi to secure mineral nutrient acquisition, especially that of phosphorus. A phosphate starvation response (PHR)‐centered network regulates AM symbiosis.

Here, we identified 520 direct target genes for the rice transcription factor OsPHR1/2/3 during AM symbiosis using transcriptome deep sequencing and DNA affinity purification sequencing. These genes were involved in strigolactone biosynthesis, transcriptional reprogramming, and bidirectional nutrient exchange.

Moreover, we identified the receptor‐like kinase, Arbuscule Development Kinase 1 (OsADK1), as a new target of OsPHR1/2/3. Electrophoretic mobility shift assays and transactivation assays showed that OsPHR2 can bind directly to the P1BS elements within the OsADK1 promoter to activate its transcription. OsADK1 appeared to be required for mycorrhizal colonization and arbuscule development. In addition, hydroponic experiments suggested that OsADK1 may be involved in plant Pi starvation responses.

Our findings validate a role for OsPHR1/2/3 as master regulators of mycorrhizal‐related genes involved in various stages of symbiosis, and uncover a new RLK involved in AM symbiosis and plant Pi starvation responses.