bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and Significance of Approximate Symmetry in Organic Pc Structures
Authors: Pratt Brock Carolyn 
Published: December 2022

AbstractA survey has been made of the well determined (R≤0.050) organic crystal structures that have only a single glide plane (e. g., are in space group Pc) and that have more than one crystallographically independent formula unit (Z′>1); the goal was to discover what fraction have additional approximate symmetry. Of the 377 unique structures examined 8 % should almost certainly been refined in a higher‐symmetry unit cell; 86 % of the remaining 347 have approximate symmetry that is periodic in at least one dimension. While these percentages are similar to those found for P1 structures (C. P. Brock, Acta Crystallogr., Sect. B 2022, 78, 576–588), the types of approximate symmetry differ because 89 % of the P1, Z′>1 structures were composed of enantiopure material. The 347 reliable Pc structures include 118 that are slightly distorted or mimicked Cc and P21/c structures, 15 of which were reported as having been determined at room temperature. The distortions in another 72 are so large that the approximate symmetry must be seen as periodic in two dimensions only. These results suggest that symmetry lowering may accompany transformation of a crystal nucleus to a macroscopic crystal.
Undergraduate students' experiences of participating in a Danish respite programme for young carers—A mixed methods study
Authors: Nissen Karina Brix , Laursen Sisse Heiden , Udsen Flemming Witt , Haslund‐Thomsen Helle 
Published: December 2022

AbstractBackgroundAge‐appropriate communication and interaction are essential when meeting young carers, requiring in‐depth knowledge and experience. Volunteer programmes may enhance undergraduate students' competencies in this regard. This pilot study evaluated undergraduate students' perceptions of volunteering on the Buddies for Children and Youngsters (BCY) programme by assessing the extent to which students experienced an improvement in their relational and communication competencies and/or felt better equipped for their future work.MethodsThe researchers conducted a mixed methods study with a parallel design, focussing on undergraduate students from the University College of Northern Denmark within the field of nursing, teaching, pedagogy, physiotherapy, and occupational therapy. The students participated in the programme for at least 4 months.ResultsForty‐two students responded to a questionnaire, and 17 students were selected to participate in four focus groups. The results showed that participation in the programme improved the students' communication and relational competencies to some degree. The programme provided the students with experience of age‐related communication on both informal and difficult topics, and of building relationships and solving relational challenges. Also, the programme generally equipped students for future work with young carers and children.ConclusionIn conclusion, the BCY programme is a relevant supplement to regular educational activities. Decision makers within politics of health, health planning and management, should therefore consider implementation of such programmes in relevant educational areas.
The adoption of human resource practices to support employees affected by intimate partner violence: Women representation in leadership matters
Authors: Chan‐Serafin Suzanne , Sanders Karin , Wang Lu , Restubog Simon Lloyd D. 
Published: December 2022

AbstractIntimate partner violence (IPV) is a global public health issue that negatively impacts organizations and their employees. Research suggests that organizations can play a supportive role to lessen this negative impact. However, it has been relatively silent on the conditions under which organizations choose to play such a role. Integrating social role and critical mass perspectives, we examine the extent to which organizations adopt human resource (HR) practices to support employees affected by IPV. Specifically, we argue that organizations are more likely to adopt IPV‐related HR practices when they are led by female Chief Executive Officers (CEOs) and Top Management Teams (TMTs) with more female members. Furthermore, we argue that when women's representation reaches a critical mass plateau, appointing more women in TMTs has no incremental impact, and this non‐linear relationship moderates the CEO gender effect. Overall, we found support for our hypotheses based on a survey study of HR professionals from 414 Australian organizations (Study 1) and an archival study using 2 years of the Workplace Gender Equality Agency data from 4186 Australian organizations (Study 2). Theoretical and practical implications on the influence of gender configurations in leadership positions on the adoption of diversity, equity, and inclusion‐related HR practices are discussed.
Geographical and spatial disparities in the incidence and survival of rare cancers in Australia
Authors: Dasgupta Paramita , Cameron Jessica K. , Cramb Susanna M. , Trevithick Richard W. , Aitken Joanne F. , Mengersen Kerrie , Baade Peter D. 
Published: December 2022

AbstractRare cancers collectively account for around a quarter of cancer diagnoses and deaths. However, epidemiological studies are sparse. We describe spatial and geographical patterns in incidence and survival of rare cancers across Australia using a population‐based cancer registry cohort of rare cancer cases diagnosed among Australians aged at least 15 years, 2007 to 2016. Rare cancers were defined using site‐ and histology‐based categories from the European RARECARE study, as individual cancer types having crude annual incidence rates of less than 6/100 000. Incidence and survival patterns were modelled with generalised linear and Bayesian spatial Leroux models. Spatial heterogeneity was tested using the maximised excess events test. Rare cancers (n = 268 070) collectively comprised 22% of all invasive cancer diagnoses and accounted for 27% of all cancer‐related deaths in Australia, 2007 to 2016 with an overall 5‐year relative survival of around 53%. Males and those living in more remote or more disadvantaged areas had higher incidence but lower survival. There was substantial evidence for spatial variation in both incidence and survival for rare cancers between small geographical areas across Australia, with similar patterns so that those areas with higher incidence tended to have lower survival. Rare cancers are a substantial health burden in Australia. Our study has highlighted the need to better understand the higher burden of these cancers in rural and disadvantaged regions where the logistical challenges in their diagnosis, treatment and support are magnified.
Publication trends and usefulness of research in hysteroscopic myomectomy for heavy menstrual bleeding: A review of the published literature
Authors: Dreessen Janique R. J. , van der Meulen Julia F. , Bongers Marlies Y. , Mol Ben W. J. , Langenveld Josje 
Published: December 2022

AbstractDespite the amount of research into hysteroscopic myomectomy, questions about the optimal treatment of heavy menstrual bleeding remain. This study reviewed publication trends on this topic from 2002 to 2019 and assessed the usefulness of studies. A total of 580 articles were published on PubMed in this time frame, in 15 different languages. There were meta‐analyses (1.6%), systematic reviews (12%), and randomized controlled trials (4.2%). Twelve percent were published in high impact factor journals. After applying our selection criteria, the usefulness of 37 articles was assessed: one article scored high, 31 scored moderate, and five scored low. The costs of these studies were estimated at US$ 971 700.
Influence of pre‐eclampsia on 2‐year neurodevelopmental outcome of very‐low‐birth‐weight infants
Authors: Chang Hao‐Yang , Chen Chie‐Pein , Sun Fang‐Ju , Chen Chen‐Yu 
Published: December 2022

AbstractObjectiveTo evaluate the influence of maternal pre‐eclampsia on neurodevelopmental outcome in very‐low‐birth‐weight (VLBW) infants at 6, 12, and 24 months of corrected age.MethodsWe conducted a retrospective cohort study of singleton VLBW infants between 2011 and 2018. The participants were divided into three groups: (1) mothers without pre‐eclampsia, (2) pre‐eclampsia without severe features, and (3) pre‐eclampsia with severe features. The Bayley Scales of Infant Development third edition (BSID‐III) was used to assess the neurodevelopment of participants. A BSID‐III score < 85 was defined as neurodevelopmental impairment (NDI).ResultsOverall, 482 VLBW infants born to 482 mothers were enrolled, of whom 327 mothers did not have pre‐eclampsia and 155 mothers had pre‐eclampsia (58 without and 97 with severe features). The infants born to mothers with pre‐eclampsia with severe features had the lowest BSID‐III scores at 6, 12, and 24 months. After adjustments, maternal pre‐eclampsia with severe features was significantly associated with cognitive NDI in their infants (adjusted odds ratio [aOR] 4.14) and language NDI (aOR 3.37) at 2 years of corrected age.ConclusionsVLBW fetuses born to mothers with pre‐eclampsia with severe features have poorer 2‐year neurodevelopmental outcome, which mainly manifests in the cognitive and language domains.
Importance of the early diagnosis of incarcerated gravid uterus: Case report and systematic review
Authors: Pina Moreno Juan Manuel , Ruiz Minaya María , Fraile López Andrea , Feltrer Hidalgo Marta , Ortega Abad Virginia , García‐Tizón Larroca Santiago 
Published: December 2022

AbstractObjectiveTo examine whether the early diagnosis of uterine incarceration before 20 weeks of gestation improves maternal‐perinatal prognoses.MethodsA systematic review of all of the cases published in the past 30 years that met the inclusion and exclusion criteria was performed and reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta‐Analyses recommendations. A comparative analysis of diagnoses before and after 20 weeks of gestation was performed.ResultsEighty‐nine studies with a total of 146 cases of uterine incarceration during pregnancy were included. For cases of incarceration diagnosed before 20 weeks of gestation, a higher proportion of clinical symptoms was observed; however, a lower proportion of complications, such as premature delivery, need for cesarean section, and poor perinatal outcomes, were observed (P < 0.05). The proportion of spontaneous resolution and minimally invasive techniques for the treatment of incarceration was significantly higher among patients diagnosed with this pathology before 20 weeks (P < 0.05).ConclusionThe literature indicates that uterine incarceration is a rare complication during pregnancy with better maternal‐perinatal results if diagnosed earlier than 20 weeks.
A randomized controlled trial comparing combined medical and mechanical method for early mid‐trimester abortion (13–20 weeks)
Authors: Sharma Chanderdeep , Dadhwal Ankita , Soni Anjali 
Published: December 2022

AbstractObjectiveTo examine the combined effect of a medical and mechanical method on induction‐to‐abortion interval (IAI) in women undergoing early mid‐trimester abortion (MTA) (13–20 weeks of pregnancy).MethodsA randomized controlled trial was conducted among women undergoing MTA. Primary outcome was IAI. At enrollment, 60 women were randomized (group 1: medical method alone [mifepristone 200 mg, then 48 h later vaginal misoprostol 400 μg every 4 h] versus group 2: combined medical and mechanical method [transcervical Foley catheter inflated with 60 ml of normal saline]). Demographic and clinical data were collected at enrollment and abortion.ResultsWomen in group 2 had statistically significantly shorter IAI (mean ± standard deviation: 347 ± 130 min vs. 640 ± 242 min, for group 2 and group 1, respectively; P < 0.001). All the women in group 2 had complete abortion within 12 h, compared with 19 (63%) in group 1 (P < 0.001). Median number of doses of vaginal misoprostol (400 μg every 4 h) required in group 1 was 4 (interquartile range [IQR] 3–5) versus 1 (IQR 1–3) in group 2 (P < 0.001). Statistically significantly fewer women required additional oxytocin (group 1 vs. group 2; 4 vs. zero, respectively, P = 0.038). All women in the study had complete abortion. There was no significant difference with respect to maternal complications.ConclusionA combined medical and mechanical method significantly shortens the IAI (P < 0.001) in women undergoing early MTA (13–20 weeks of pregnancy).Trial RegistrationClinical Trial Registry of India www.ctri.nic.in CTRI/2020/12/030077 (date; 28‐12‐2020).
Evaluation of external validity of the OVHIPEC‐1 trial in a real‐world population
Authors: van Stein Ruby M. , Sikorska Karolina , van der Aa Maaike A. , Sonke Gabe S. , van Driel Willemien J. ,   the Dutch OVHIPEC‐1 trial group
Published: December 2022

AbstractObjectiveThe OVHIPEC‐1 trial (Phase III randomised clinical trial for stage III ovarian carcinoma randomising between interval cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy) showed improved survival when interval cytoreductive surgery (CRS) was combined with hyperthermic intraperitoneal chemotherapy in patients with stage III epithelial ovarian cancer (EOC). The authors compared the control arm of the trial with a real‐world population treated in the Netherlands during the same period to explore generalizability of the trial results.MethodsFor this nationwide comparative cohort study, all patients with EOC undergoing interval CRS between 2007 and 2016 were identified from the Netherlands Cancer Registry if they fulfilled the eligibility criteria of OVHIPEC‐1 (n = 1376). Patient and treatment characteristics, and overall survival (OS) were compared between trial and real‐world populations.ResultsAge, comorbidity, BRCA status, histologic subtype, and residual disease were similar in trial and real‐world patients. Trial patients had a better performance status, higher socioeconomic status, and underwent bowel surgery more often. In a real‐world setting, patients more often received more than six cycles. The difference in OS between the trial and the real‐world populations was not statistically significant (unadjusted hazard ratio, 1.09 [95% confidence interval, 0.87–1.37]; P = 0.44).ConclusionDespite differences in patient characteristics, OS of patients treated in the control arm of OVHIPEC‐1 was similar to patients treated outside the trial. The trial population accurately represents real‐world patients with stage III EOC undergoing interval CRS in terms of outcome.
Cleavage stage at compaction—a good predictor for IVF outcome
Authors: Matot Ran , Kalma Yael , Rahav Roni , Azem Foad , Amir Hadar , Ben‐Yosef Dalit 
Published: December 2022

AbstractObjectiveTo analyze whether cleavage stage at compaction, and not only kinetics, can serve as a reliable predictor for clinical outcome.MethodsA retrospective cohort study including 1194 embryos, classified by compaction initiation stage (Group 1: compaction at fewer than eight cells, Group 2: compaction at eight cells, Group 3: compaction at more than eight cells). Of these, 815 embryos were evaluated for morphokinetic preimplantation parameters, and 379 embryos were analyzed for clinical implantation following thawing and transfer of single blastocysts during the same period.ResultsIn total, 1194 embryos were analyzed. Embryos that underwent compaction from more than eight cells (Group 3) exhibited more synchronous cleavage compared with Groups 1 and 2 (at both S2 and S3; P < 0.001), and displayed a significantly lower fragmentation rate. The likelihood of obtaining top‐quality blastocysts decreased by 73% and 44% when comparing Group 3 embryos with those of Groups 1 and 2, respectively, (P < 0.03). Clinical validation of the results shows that while compaction from fewer than eight cells barely produced blastocysts for transfer, compaction at eight or more cells is crucial for implantation and birth (birth rates 11.1% and 18.5% for Groups 2 and 3, respectively).ConclusionCleavage stage at compaction has a direct effect on blastocyst quality and subsequent pregnancy, so can be included in newly developed deep learning models for embryo selection.
An osteogenic magnesium alloy with improved corrosion resistance, antibacterial, and mechanical properties for orthopedic applications
Authors: Aboutalebianaraki Nadia , Zeblisky Peter , Sarker M. D. , Jeyaranjan Aadithya , Sakthivel Tamil S. , Fu Yifei , Lucchi John , Baudelet Matthieu , Seal Sudipta , Kean Thomas J. , Razavi Mehdi 
Published: December 2022

AbstractThe aim of this study was to develop a novel biodegradable magnesium (Mg) alloy for bone implant applications. We used scandium (Sc; 2 wt %) and strontium (Sr; 2 wt %) as alloying elements due to their high biocompatibility, antibacterial efficacy, osteogenesis, and protective effects against corrosion. In the present work, we also examined the effect of a heat treatment process on the properties of the Mg‐Sc‐Sr alloy. Alloys were manufactured using a metal casting process followed by heat treatment. The microstructure, corrosion, mechanical properties, antibacterial activity, and osteogenic activity of the alloy were assessed in vitro. The results showed that the incorporation of Sc and Sr elements controlled the corrosion, reduced the hydrogen generation, and enhanced mechanical properties. Furthermore, alloying with Sc and Sr demonstrated a significantly enhanced antibacterial activity and decreased biofilm formation compared to control Mg. Also, culturing Mg‐Sc‐Sr alloy with human bone marrow‐derived mesenchymal stromal cells showed a high degree of biocompatibility (>90% live cells) and a significant increase in osteoblastic differentiation in vitro shown by Alizarin red staining and alkaline phosphatase activity. Based on these results, the Mg‐Sc‐Sr alloy heat‐treated at 400°C displayed optimal mechanical properties, corrosion rate, antibacterial efficacy, and osteoinductivity. These characteristics make the Mg‐Sc‐Sr alloy a promising candidate for biodegradable orthopedic implants in the fixation of bone fractures such as bone plate‐screws or intramedullary nails.
Ethnic identity‐based motivation: A model emergent from US Hispanic consumers
Authors: Aguirre‐Rodriguez Alexandra , Luna David , Alvarez Cecilia M. O. , Montoya Detra 
Published: December 2022

AbstractA great deal of research has investigated how various aspects of ethnic identity influence consumer behavior, yet this literature is fragmented. The objective of this article was to present an integrative theoretical model of how individuals are motivated to think and act in a manner consistent with their salient ethnic identities. The model emerges from a review of social science and consumer research about US Hispanics, but researchers could apply it in its general form and/or adapt it to other populations. Our model extends Oyserman's (Journal of Consumer Psychology, 19, 250) identity‐based motivation (IBM) model by differentiating between two types of antecedents of ethnic identity salience: longitudinal cultural processes and situational activation by contextual cues, each with different implications for the availability and accessibility of ethnic cultural knowledge. We provide new insights by introducing three ethnic identity motives that are unique to ethnic (nonmajority) cultural groups: belonging, distinctiveness, and defense. These three motives are in constant tension with one another and guide longitudinal processes like acculturation, and ultimately influence consumers' procedural readiness and action readiness. Our integrative framework organizes and offers insights into the current body of Hispanic consumer research, and highlights gaps in the literature that present opportunities for future research.
Using transvaginal ultrasounds for the identification of follicle‐like structures ≥10 mm in a multi‐center randomized contraceptive clinical trial of three 84‐day oral ulipristal acetate regimens
Authors: Rosenberg Jessica D. , Westhoff Carolyn L. 
Published: December 2022

AbstractPurposeWe examine the use of transvaginal sonography in imaging ovarian follicles among non‐pregnant reproductive‐aged women enrolled in a contraceptive clinical trial.MethodsTen sites conducted a clinical trial comparing three oral ulipristal acetate regimens for ovulation inhibition. Enrollees underwent twice weekly transvaginal sonography and hormonal blood testing throughout treatment and until the second menses post‐treatment. The primary outcome of the present analysis was success in identifying follicles ≥10 mm in a subgroup of sonograms performed at times of likely follicular activity (estradiol <100 pg/ml and progesterone >3 ng/ml). Secondarily, an overall analysis assessed all sonograms regardless of timing.ResultsAt times of likely follicular activity, 135 women underwent 969 sonograms. The proportion of sonograms without follicles ≥10 mm ranged from 8.3% to 46.3% when stratified by site (p = .01). The odds of no follicle among higher‐body mass index (BMI) women were 1.91 times those among lower‐BMI women after controlling for site and treatment arm (95% CI: 1.13, 3.22). Results were similar for the overall population.ConclusionSonographers were less likely to identify follicles for higher‐BMI women and results varied by site. Machine quality slightly impacted sonogram results, but did not sufficiently explain site differences.
Case report: An unusual case of cecal mucosal bleeding
Authors: Kamara Maseray S. , Sugawa Choichi 
Published: December 2022

AbstractCecal mucosal bleeding is an undocumented and rare cause of lower gastrointestinal (GI) bleeding. We present a case of a 73‐year‐old woman with end‐stage renal disease and paroxysmal atrial fibrillation on apixaban who presented with lower gastrointestinal bleed. She was found to have symptomatic, acute chronic anemia requiring multiple packed red blood cell transfusions. Colonoscopy revealed a localized area of active, cecal mucosal bleeding without evidence of Dieulafoy lesion, ulcer, mass, arteriovenous malformation, or diverticula. Hemostasis was achieved with epinephrine injection and the use of bipolar electrocautery. She was later resumed on her therapeutic anticoagulation without recurrence of bleeding. Therapeutic anticoagulation in our patient with ESRD increased her risk for gastrointestinal bleeding. Had this transient, mucosal‐limited bleeding not been active during endoscopic evaluation, the etiology of her massive gastrointestinal bleeding would have been missed. This case expands the differential of acute, lower GI bleeding to include cecal mucosal bleeding, which is a rare, intermittent, cause of bleeding that is amenable to endoscopic management.
Lipase activity inhibited by aloenin A: Glycoside from Aloe vera (L.) Burm. f.—In vitro and molecular docking studies
Authors: Deora Neha , Venkatraman Krishnan 
Published: December 2022

AbstractObesity is taking over many parts of the world and has been identified as the second leading cause of preventable death, with a dramatic increase in prevalence over the last two decades. Pancreatic lipase is a lipid‐digesting enzyme that plays an important role in fat metabolism. Inhibiting pancreatic lipase is an attractive target for obesity treatment. Phytochemicals or bioactive compounds/extracts isolated from medicinal plants offer a promising platform for the development of pancreatic lipase inhibitors. This study aims to characterize and investigate the effect of aloenin A, glycoside found in Aloe vera, as a possible inhibitor of pancreatic lipase in vitro and in silico. A. vera extract had an IC50 value of 0.5472 μg/ml, whereas aloenin A had an IC50 value of 14.95 μg/mL and was found to inhibit in a competitive manner. These findings were supported by molecular docking studies, which revealed that aloenin A binds to the substrate binding site with a binding energy of − 7.16 kcal/mol, and this binding site is stabilized by three hydrogen bonds contributed by Phe77 and Asp79. Our findings suggest that the anti‐hyperlipidemic effects of A. vera on pancreatic lipase can be attributed in part to the presence of aloenin A.