bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between night shift work and breast cancer incidence: A systematic review and meta-analysis of observational studies
Authors: Hong Jiaze , He Yujing , Fu Rongrong , Si Yuexiu , Xu Binbin , Xu Jiaxuan , Li Xiangyuan , Mao Feiyan 
Published: April 2022

AbstractThe purpose of this study was to investigate the relationship between night shift work and breast cancer (BC) incidence. A search was performed in PubMed, EBSCO, Web of Science, and Cochrane Library databases before June 2021. The exposure factor of this study is night shift work, the primary outcome is the risk of BC. A total of 33 observational studies composed of 4,331,782 participants were included. Night shift work increases the risk of BC in the female population (hazard ratio [HR] = 1.20, 95% confidence interval [Cl] = 1.10–1.31,p< 0.001), especially receptor-positive BC, including estrogen receptor (ER)+ BC (HR = 1.35,p< 0.001), progesterone receptor (PR)+ BC (HR = 1.30,p= 0.003), and human epidermal growth factor receptor 2 (HER2)+ BC (HR = 1.42,p< 0.001), but has no effect on HER2− BC (HR = 1.10,p= 0.515) and ER−/PR− BC (HR = 0.98,p= 0.827). The risk of BC was positively correlated with night shift working duration, frequency, and cumulative times. For women who start night work before menopause, night work will increase the incidence of BC (HR = 1.17,p= 0.020), but for women who start night work after menopause, night work does not affect BC (HR = 1.04,p= 0.293). Night work can increase the incidence of BC in the female population. The effect of long working hours, frequency, and the cumulative number of night shifts on BC is influenced by menopausal status.
Digging Holes and Building Walls: Spatial Imaginations of the Law in Stories by Franz Kafka and Rachel Shihor
Authors: Schmalz Dana 
Published: April 2022

Abstract
Stories shape our thinking about legal relationships and the challenges of law. This paper is interested in the ways, in which spatial constellations are imagined in connection with the law. It analyzes selected stories by Franz Kafka and Rachel Shihor alongside each other. Legal themes permeate these stories. Their fictive dialogue brings forth contrasting imaginations of community, universalism, and human limitations. Starting with their variations on the Tower of Babel story, the paper then discusses Kafka’s “The Great Wall of China”, “Before the Law”, and “The Burrow”, as well as Shihor’s “The Bridge”, “The Bus”, “The Door”, and “Questions”. These stories illuminate Kafka’s and Shihor’s rich, narrative vocabulary of spatial imaginations of the law, and the fruitful contrast of their perspectives.
Broken Justice: Justice and Relativism in the Work of Friedrich Dürrenmatt
Authors: Maestri Enrico 
Published: April 2022

Abstract
In this essay I intend to examine and discuss three theses that recurrently appear in the works of Friedrich Dürrenmatt. I shall first identify the three theses in order to clarify the focus of my research. Dürrenmatt puts forward at least three theses to relating to 1. the paradoxical nature of human justice; 2. the demystification of apparent atheistic nihilism; 3. the neutralising effect of the contradiction inherent in divine justice. The conclusion I will try to reach is that if one accepts the three above-stated theses, justice is broken, but not irreparably.
In situ synthesis of Ag NPs in the galactomannan based biodegradable composite for the development of active packaging films
Authors: Malwade Mayuri , Chaudhari Rajnandini , Sharma Lokesh , Kahandal Amol , Sirdeshmukh Vedashree , Rajdeo Kishor , Tagad Chandrakant 
Published: April 2022

Abstract
The application of plastics in the food and agriculture industries as packaging materials is immense. However, the damage caused to the environment by accumulating such non-biodegradable plastics has led to the development of better alternatives. This has caused an increase in the use of synthetic polymers and proteins for the production of biodegradable films as an alternative to packaging plastics. In this study, a novel approach for the fabrication of homogenous and biodegradable films using PVA/galactomannan/gelatin (PGG) composite has been developed. The in-situ synthesis of silver nanoparticles (Ag NPs) was attained by hydrothermal reduction. The formation of Ag NPs within the PGG composite imparted substantial antimicrobial properties to the films. The optical properties of Ag NPs-PGG composite and its films were characterized using UV–vis spectrophotometry, Fourier transfer infrared spectroscopy (FTIR), and scanning electron microscope (SEM). The Ag NPs-PGG films were evaluated for their physical and mechanical properties and cytotoxicity and were found to have high tensile strength, flexibility and biocompatibility. The films were also subjected to an in-door soil burial test for 15 days and were observed to decompose rapidly. The developed Ag NPs-PGG composite films with bactericidal properties have potential use in food packaging and various biomedical applications.
The stability increase of α-amylase enzyme from Aspergillus fumigatus using dimethyladipimidate
Authors: Yandri Yandri , Nurmala Nurmala , Suhartati Tati , Satria Heri , Hadi Sutopo 
Published: April 2022

Abstract
This study’s purpose is to improve the α-amylase enzyme’s stability from Aspergillus fumigatus applying dimethyladipimidate (DMA). It was conducted in different stages, including production, isolation, purification, modification, and the characterization of native and modified enzymes by the DMA addition. The enzyme activity was specified using the Fuwa and Mandels methods, while the protein level was conducted by the Lowry method. The results indicated that the native enzyme contains a specific activity of 7010.42 U/mg, with an increase of 7.8 times than the crude extract, which contains 904.38 U/mg. Meanwhile, the native enzyme contains an optimum pH of 5 at 55 °C, with residual activity of 17.17% after 60 min of incubation at 55 °C and a half-life of 25.86 min. After the DMA addition with 0.5, 1, and 1.5% concentration, the enzymes had 5.5 optimum pH and 65 °C temperature. Meanwhile, after 60 min of incubation at 65 °C, the modified enzymes had 54.17, 46.18, and 34.44% of residual activity, and 85.55 58.25 and 37.46 min of half-lives, respectively. This showed that the addition of DMA to the native α-amylase from A. fumigatus increased the stability of the modified enzymes by 1.5–3.3 times than the native enzyme.
Weniger ist mehr: Glas in der Sântana de Mureş-Černjachov Kultur (Kreis Vaslui/Ostrumänien)
Authors: Grumeza Lavinia 
Published: April 2022

Zusammenfassung
In diesem Beitrag werden die Glasgefäße und Mosaikperlen mit Gesichtsmasken aus Fundorten der Sântana de Mureş-Černjachov Kultur in Ostrumänien, Kreis Vaslui, vorgestellt. In der für Vaslui angelegten Datenbank (angelehnt an die Systematik im Corpus der römischen Funde im europäischen Barbaricum) sind 84 Glasgefäße unterschiedlicher Typen verzeichnet, datierend vom Ende des 3. bis zum Beginn des 5. Jahrhunderts n. Chr. (bes. der Typ Kowalk und konische Becher mit Facettierung). Im Gräberfeld von Bârlad-Valea Seacă fand sich die bislang größte Anzahl an Glasgefäßen (50 %). Nur indem zukünftig umfassende Fundkataloge für Glaswaren auch für die Nachbarregionen erarbeitet werden, wird man einen Überblick über die sozioökonomischen Beziehungen, die Technologien und den Handel in der gesamten Region erhalten.
“My Dear Fatherland, When Will You Ever Flourish?” Recent Historical Literature on Georgia
Authors: Hausmann Guido 
Published: April 2022

Abstract
The history of Georgia and the entire South Caucasus or Transcaucasia is a heavily marginalised field in international historical scholarship. This book review essay identifies and discusses major trends in recent publications on the modern history of Georgia in order to improve the chances of its integration into larger historical contexts and debates.
SMART: An Open-Source Extension of WholeBrain for Intact Mouse Brain Registration and Segmentation
Authors: Jin Michelle , Nguyen Joseph D. , Weber Sophia J. , Mejias-Aponte Carlos A. , Madangopal Rajtarun , Golden Sam A. 
Published: April 2022

AbstractMapping immediate early gene (IEG) expression across intact mouse brains allows for unbiased identification of brain-wide activity patterns underlying complex behaviors. Accurate registration of sample brains to a common anatomic reference is critical for precise assignment of IEG-positive (“active”) neurons to known brain regions of interest (ROIs). While existing automated voxel-based registration methods provide a high-throughput solution, they require substantial computing power, can be difficult to implement and fail when brains are damaged or only partially imaged. Additionally, it is challenging to cross-validate these approaches or compare them to any preexisting literature based on serial coronal sectioning. Here, we present the open-source R package SMART (Semi-Manual Alignment to Reference Templates) that extends the WholeBrain R package framework to automated segmentation and semi-automated registration of intact mouse brain light-sheet fluorescence microscopy (LSFM) datasets. The SMART package was created for novice programmers and introduces a streamlined pipeline for aligning, registering, and segmenting LSFM volumetric datasets across the anterior-posterior (AP) axis, using a simple “choice game” and interactive menus. SMART provides the flexibility to register whole brains, partial brains or discrete user-chosen images, and is fully compatible with traditional sectioned coronal slice-based analyses. We demonstrate SMART’s core functions using example datasets and provide step-by-step video tutorials for installation and implementation of the package. We also present a modified iDISCO+ tissue clearing procedure for uniform immunohistochemical labeling of the activity marker Fos across intact mouse brains. The SMART pipeline, in conjunction with the modified iDISCO+ Fos procedure, is ideally suited for examination and orthogonal cross-validation of brain-wide neuronal activation datasets.
Partisipasi Masyarakat pada Pemilihan Gubernur Jakarta 2017
Authors: Sukri Mhd. Alfahjri 
Published: April 2022

Abstract: This study aims to see and analyze how the public's participation in the 2017 DKI Jakarta Governor Election (Pilgub), especially in Bangka Village, Mampang Prampatan District, South Jakarta TPS 30 in the first round of the DKI Jakarta Pilkada, and how the DKI Jakarta Pilkada is held at TPS 30 2017. The research method used in this research is a qualitative method by conducting field studies, observations, collecting data through using books and documents. The results of this study indicate that the participation of the community in Bangka TPS 30 RW 5 (RT 4 and 5) is high, especially the participation of the elite (high economy) who lives in RT 5. The number of people in RT 5 is present and the low number of golput (which does not use the right to vote) indicates that the participation of the elite is high. Huntington and Nelson's statement which states that a high or good economic level will result in high participation is evident at this TPS 30. However, there are some old problems in the implementation of the first round of the DKI Jakarta Pilkada in the Bangka TPS 30 Village, namely the DPT problem, such as residents whose names are not on the DPT and the DPTb which slightly resulted in residents not being able to vote. Poor implementation of Pilkada can result in decreased community participation. But overall the Pilkada at TPS 30 went smoothly and there were no problems with religious sentiment.Abstrak: Penelitian ini bertujuan untuk melihat dan menganalisa bagaimana partisipasi masyarakat pada Pemilihan Gubernur (Pilgub) DKI Jakarta tahun 2017 khususnya di Kelurahan Bangka, Kecamatan Mampang Prampatan, Jakarta Selatan TPS 30 pada Pilkada DKI Jakarta putaran pertama, dan bagaimana penyelenggaraan Pilkada DKI Jakarta di TPS 30 tahun 2017 tersebut. Metode penelitian yang digunakan dalam penelitian ini adalah metode kualitatif dengan melakukan studi lapangan, observasi, mengumpulkan data-data melalui buku dan dokumen. Hasil dari penelitian ini menunjukkan bahwa partisipasi masyarakat Kelurahan Bangka TPS 30 RW 5 (RT 4 dan 5) termasuk tinggi, terutama partisipasi dari kalangan elite (ekonomi tinggi) yang tinggal di RT 5. Banyaknya masyarakat RT 5 yang hadir dan sedikitnya angka golput (yang tidak menggunakan hak pilih) menunjukkan bahwa partisipasi kaum elite tersebut tinggi. Pernyataan Huntington dan Nelson yang menyatakan bahwa tingkat ekonomi yang tinggi atau baik akan menghasilkan partisipasi yang tinggi, terbukti di TPS 30 ini. Namun, terdapat beberapa permasalahan lama pada penyelenggaraan Pilkada DKI Jakarta putaran pertama Kelurahan Bangka TPS 30 yaitu masalah DPT, seperti warga yang namanya tidak ada di DPT serta DPTb yang sedikit mengakibatkan warga tidak bisa memilih. Buruknya pelenggaraan Pilkada dapat berakibat pada menurunnya partisipasi masyarakat. Namun secara keseluruhan penyelenggaraan Pilkada di TPS 30 berjalan aman serta tidak ada masalah sentiment agama.
New Perspectives for Living Traditions: Intangible Cultural Heritage in North-East Hungary
Authors: Tóth Arnold 
Published: April 2022

AbstractThe UNESCO World Heritage Convention (1972) was originally focused on nature conservation and built heritage. The immaterial aspect of the worldwide heritage discourse arrived at a turning point in 2003, when the Convention for the Safeguarding of Intangible Cultural Heritage was adopted. The definition of the intangible cultural heritage provides essential frames for a wide range of interpretations. The UNESCO concept focuses on inclusive, representative and community-based traditions which are contemporary and living at the same time. In this sense, the intangible cultural heritage conception is based on the fundamental dichotomy of tradition and modernity. For the communities concerned, a new perspective for living traditions is the process from tradition to heritage. There are four essential features of this process: participation, consciousness, organization and valorization. They can make a difference between tradition and heritage. The Hungarian model for the implementation of the UNESCO Convention is based on a bottom-up system, where the heritage bearers themselves initiate the nomination process for the National Inventory. It is based on their strong commitment to their heritage and it relies on their involvement and participation. In this paper, three case studies from North-East Hungary (Borsod-Abaúj-Zemplén County) represent different ways of “creating a heritage.” The various patterns are closely related to the ideas of identity, community cohesion, tourism, local economy and the preservation of living traditions.
Visualization of the effect of TR100 anti-cancer compound on membrane nanotubes with SR-SIM microscopy
Authors: Hencz Alexandra Júlia , Somogyi Pál , Halász Henriett , Szabó-Meleg Edina 
Published: April 2022

AbstractOne of the most dangerous diseases is cancer, nearly 2 million new cancer types are diagnosed each year, worldwide, causing most of the death. Therefore, cancer is in the focus of many types of research. To prevent the proliferation and spreading of malignant cells, several compounds have been developed in chemotherapy, however, a significant proportion of these have serious side effects, and resistance is commonly emerging early after administration. Tumor cells require tropomyosin-containing actin network for their growth and survival. The tropomyosin profile is considerably changed in cancers resulting in the dramatic rearrangements of the actin cytoskeleton structure, therefore anti-tropomyosin compounds can be a new perspective in cancer therapy, such as TR100 which was reported to be capable of destroying cancer cells in a highly tumor-specific manner by increasing the depolymerization of the actin filament. On the other hand tumor cells can commonly communicate with each other via membrane nanotubes (NTs) for which actin is essential for growth. Tumor cell NTs may transport not only signal molecules, or cell organelles, but resistance factors against chemotherapeutic agents to help to survive. Immune cells also frequently use membrane nanotubes for communication, therefore, in this study we focused on the visualization of the effect of TR100 on the morphology and formation of B lymphoma cell NTs with superresolution structured illumination microscopy. TR100 treatment caused spectacular changes on the NT forming capability and the morphology of B cells in a concentration dependent manner, while low concentration of the agent significantly promoted NT formation, and at the same time produced shorter and thicker tubes in the early stage of their formation, in higher concentration it affected mainly only the cells, causing the rounding and finally the death of them. We were not able to detect any significant change on cells with extended nanotubular network, suggesting that TR100 is a less potent candidate in anti-cancer therapy.
Experience of using the ABBI biopsy procedure in the diagnosis of non-palpable breast masses
Authors: Gubaidullin H. M. , Seagal E. I. , Khasanov R. Sh. , Nagumanov E. V. , Ismagilov A. KH. 
Published: April 2022

The Advanced Breast Biopsy Instrumentation procedure the improved biopsy csystem of the mammary gland was performed in 13 women aged 34 to 72 with nonpalpable mammographic lesions. It is a stereoscopic table making it possible to perform biopsy of the mammagraphic lesions of the mammary gland tissue by cannulas diameter up to 2 sm in under X-ray control. Microcalcinates are found in 3 patients (22,8%), the local tissue change in 3 patients (22,8%) focal shadows in 7 patients (53,2%).
The lesion size 5 mm is found in 16% of the patients, from 5,1 to 10 mm in 25% of the patients, from 10,1 to 20 mm in 59% of the patients. The cancer was diagnosed in 3 cases (22,8%) on the 7 and 10 mm sites, the atypical hyperplasia in 2 cases (8,3%), other benign pathology in 53,2% of the cases. In all the cases the foci removal nas corfirmed by histology. The high efficiency of the biopsy stereotaxic method of the mammary gland which removes the roentgenosus-picious site as the single tissue preparation.
Servikal blok altında karotis endarterektomi operasyonu sonuçlarımız: Anadolu’da bir merkezde ilk uygulama
Authors: BEYAZ Metin Onur , URFALI Senem , KAYA Sefer , ORUÇ Dilan , ÇÖMEZ Mehmet , HAKİMOĞLU Sedat , KOYUNCU Onur , MELEK Ismet , FANSA İyad 
Published: April 2022

Amaç: Karotis endarterektomi operasyonu genel anestezi ile uygulanabildiği gibi, bölgesel uygulanabilen; servikal rejyonel blok, lokal-rejyonel kombine anestezi ya da lokal infiltrasyon anestezisi altında yapılabilir. Bu çalışmada rejyonel blok uygulaması ile karotis endarterektomi uygulama deneyimlerimizi sunmayı amaçlıyoruz.
Yöntem: Eylül 2020- Ocak 2022 tarihleri arasında karotis arterine endarterektomi operasyonu yapılan 61 hastanın cerrahi sonrası 30 gün süreyle erken dönem sonuçları retrospektif irdelenmiştir. Hastalara ait yaş, cinsiyet, risk faktörleri, şant kullanımı, operasyon süresi, nörolojik olaylar, mortalite ve morbidite değerlendirilmiştir.
Bulgular: Toplam 61 hastanın verileri retrospektif olarak incelenmiştir. Hastalardan 15’i kadın, 46’sı erkekti. Ortalama yaş 61.6±9.1 (48-88) yıl olarak hesaplandı. Semptomatik hasta sayısı 51 idi. 10 hasta asemptomatik olup stenoz derecesi %70’in üzerindeydi. 11 hastada her iki tarafa endarterektomi uygulandı. Toplam olarak 72 karotis endarterektomi operasyonu gerçekleştirildi.
Ortalama işlem süresi 77.6±19.7 dakika, karotis klemp süresi 29.4±11.5 dakika olarak hesaplandı. Taburcu edilen hiçbir hastada postoperatif ilk ay içinde majör nörolojik olay, kanama, enfeksiyon ya da ölüm ile karşılaşılmadı.
Sonuç: Karotis endarterektomi operasyonu artan tecrübe ile birlikte rejyonel servikal blok altında güvenle gerçekleştirilebilir.
ВЛИЯНИЕ УЛЬТРАЗВУКОВОГО ИЗЛУЧЕНИЯ НА КИНЕТИКУ ПРОЦЕССА ЩЕЛОЧНОЙ ПЕРЕРАБОТКИ АЛЮМИНИЕВЫХ ОТХОДОВ
Authors: Новиков Александр Станиславович , Мостовщиков Андрей Владимирович 
Published: April 2022

Ссылка для цитирования: Новиков А.С., Мостовщиков А.В. Влияние ультразвукового излучения на кинетику процесса щелочной переработки алюминиевых отходов // Известия Томского политехнического университета. Инжиниринг георесурсов. – 2022. – Т. 333. – № 3. – С. 49-56.
Актуальность исследования обусловлена необходимостью разработки новых методик по утилизации металлических отходов. Данное направление, при участии различных интенсифицирующих воздействий, относится к ресурсосберегающим, технологическим, минимизирующим объемы капитальных затрат на сырьё, производство и последующую реализацию. Цель: изучить физико-химические закономерности процесса щелочной переработки алюминиевых отходов в поле ультразвука, предложить механизм этого процесса и на основании установленных закономерностей и предложенного механизма разработать методику щелочной переработки алюминиевых отходов. Объекты: образцы алюминиевых отходов в виде пластинок и стружки. Методы: волюмометрия, дифференциально термический анализ, оценка и анализ кинетических кривых процесса при разных температурах. Результаты. Проведен анализ кинетических кривых, рассчитаны константы скоростей процесса при различных температурах, найден порядок химической реакции. По рассчитанной энергии активации процесса была дана характеристика о кинетической области процесса. Найдено массовое содержание алюминия в образцах. Согласно полученным данным, воздействие на систему ультразвуком способствовало увеличению скорости химического процесса на 44,1 % при 303 К; на 25,4 % при 313 К. Сам процесс начинался в течение 1…3 секунд и завершался в течение нескольких минут, что подтверждает возможность утилизации алюминиевых отходов с помощью щелочных растворов при невысоких температурах. Полученный водород можно использовать в водородной энергетике, поскольку он является единственным газообразным продуктом реакции, что снимает необходимость в его очистке перед транспортировкой. Отфильтрованный гидроксид алюминия можно использовать в силикатной промышленности для получения пористой корундовой керамики.
RANCANG BANGUN ALAT PRAKTIKUM KALORIMETER COFFEE-CUP PENGUKUR KALOR JENIS BERBANTUAN ARDUINO UNO
Authors: Aisyah Nur , Harijanto Alex , Nuraini Lailatul 
Published: April 2022

Practical activities are a series of activities carried out to apply skills or practice something that requires practical tools in its implementation. The purpose of using practical tools is to meet the needs of practitioners in carrying out a process. One of the physics concepts that can be explained through practical activities is calorimetry. Specific heat is one of the observations made during the practicum using a calorimeter. The specific heat of the material is usually measured using a coffee-cup calorimeter manually. The obstacle faced by the practitioner during the calorimetry practicum is that the measurement of the dependent variables takes up the time and attention of the practitioner in the implementation of the practicum. The objectives of this research are (1) to design an Arduino Uno-based calorimeter practicum tool; (2) explain the work system of the Arduino Uno-based calorimeter practicum tool; (3) measuring the amount of heat on the Arduino Uno-based calorimeter practicum tool; (4) comparing the effectiveness of the Arduino Uno-based calorimeter practicum tool with the coffee-cup calorimeter practicum tool. This study uses a type of research and development (Research and Development) with a Nieveen design conducted in the Laboratory of Physics Education Study FKIP Jember University. Nieveen's design research procedures include Preliminary Research, Prototyping Stage, and Assessment Stage (summative evaluation). Based on the results of data analysis, there is a very strong relationship between the data from the measurement results of the design of the tool and the data from the results of the measuring instruments that have been standardized. The results of the measurement of the specific heat of the material using the design of the tool indicate a conformity with the previous theoretical study.
Key word: arduino-based, calorimeter coffee-cup, calorimetry, sensor loadcell, sensor DHT22.