bluuebunny/crossref_metadata_2025_split huggingface dataset:
The antimicrobial activity of cethromycin against Staphylococcus aureus and its relationship with MLST, erm genes and MLSB phenotypes
Authors: Hu Yuechen , Ouyang Lili , Li Duoyun , Deng Xiangbin , Xu Hongbo , Yu Zhijian , Fang Yeqing , Zheng Jinxin , Chen Zhong , Zhang Haigang 
Published: December 2022

Abstract
Background
This study aims to explore the antibacterial activity of cethromycin against Staphylococcus aureus, and its relationship with multilocus sequence typing (MLST), erm genes and macrolide-lincosamide-streptogramin B (MLSB) phenotypes of S. aureus.
Results
The minimum inhibitory concentrations (MICs) of cethromycin against 245 S. aureus clinical isolates ranged from 0.03125 to ≥ 8mg/L, with the resistance rate of 38.8% in 121 methicillin-resistant S. aureus (MRSA) and 37.1%in 124 methicillin-sensitive S. aureus (MSSA).This study also found that cethromycin had strong antibacterial activity against S. aureus, with the MIC ≤ 0.5 mg/L in 55.4% of MRSA and 60.5% of MSSA, respectively. The main MLSTs of 121 MRSA were ST239 and ST59, and the resistance rate of ST239 isolates to cethromycin was higher than that in ST59 isolates. The top five MLSTs of 124 MSSA were ST7, ST59, ST398, ST88 and ST120, but there was no difference in the resistance of MSSA to cethromycin between these STs. The resistance of ermA isolates to cethromycin was higher than that of ermB or ermC isolates in MRSA, but the resistance of ermB or ermC isolates to cethromycin was higher than that of ermA isolates in MSSA.The resistance of constitutive MLSB (cMLSB) phenotype isolates to cethromycin was higher than that of inducible MLSB (iMLSB) phenotype isolates in MRSA or MSSA. The ermA,ermB and ermC genes was mainly found in ST239, ST59and ST1 isolates in MRSA, respectively. Among the MSSA, the ermC gene was more detected in ST7, ST88 and ST120 isolates, but more ermB genes were detected in ST59 and ST398 isolates. The cMLSB phenotype was more common in ST239 and ST59 isolates of MRSA, and was more frequently detected in ST59, ST398, and ST120 isolates of MSSA.
Conclusion
Cethromycin had strong antibacterial activity against S. aureus. The resistance of MRSA to cethromycin may had some clonal aggregation in ST239. The resistance rate of S. aureus carrying various erm genes or MLSB phenotypes to cethromycin was different.
Work and health during the COVID-19 crisis among Dutch workers and jobseekers with (partial) work disabilities: A mixed methods study
Authors: de Visser Mara , Anema Johannes R. , Huysmans Maaike A. , de Graaf-Zijl Marloes 
Published: December 2022

Abstract
Background: The consequences of restrictive measures during the COVID-19 outbreak have potentially been enormous, especially for those in a vulnerable position in the labour market. This study aims to describe the impact of the COVID-19 crisis on work status, working conditions, and health among people with (partial) work disabilities—with and in search of work—during the COVID-19 pandemic in the Netherlands.
Methods: A mixed methods design was used, combining a cross-sectional online survey and ten semi-structured interviews with people with a (partial) work disability. The quantitative data included responses to job-related questions, self-reported health, and demographics. The qualitative data consisted of participants’ perceptions about work, vocational rehabilitation, and health. We used descriptive statistics to summarize the responses, conducted logistic and linear regression and integrated our qualitative findings with the quantitative findings, aiming at complementarity.
Results: Five hundred and eighty-four participants (response rate 30.2%) completed the online survey. The majority of participants experienced no change in work status: 39 percent remained employed, 45 percent remained unemployed, six percent of respondents lost their job, and ten percent became employed during the COVID-19 crisis. In general, the results showed a deterioration in self-rated health during the COVID-19 outbreak, both for participants at work and in search of work. Participants who lost their job during the COVID-19 crisis reported the highest deterioration in self-rated health. Interview findings revealed that loneliness and social isolation were persistent during the COVID-19 crisis, especially among those in search of work. Additionally, employed participants identified a safe work environment and the possibility to work at the office as important factors for overall health.
Conclusions: The vast majority of study participants (84.2%) experienced no change in work status during the COVID-19 crisis. Nonetheless, people at work and in search of work encountered barriers to maintaining or (re)gaining employment. People with a (partial) work disability who lost their job during the crisis appeared to be most affected in terms of health. Employment and health protections could be strengthened for persons with WD to better prepare them for the next crisis.
Construction of chiral through-space luminophores via symmetry breaking triggered by sequenced chlorination
Authors: Xie Yufeng , Liu Huaying , Li Zhong-Liang , Zhang Xin , Song Lijuan , Zhou Kang , Yuan Feng , You Hengzhi , Zhao Engui , He Zikai 
Published: December 2022

Abstract
The construction of molecular chirality is crucial for exploring novel luminophores with chiroptical properties. Classic asymmetric synthesis of chiral center or axial is not powerful enough on through-space architecture. Accessible methodologies for breaking molecular symmetry could be promising but remain less investigated. Herein, we report a novel methodology for constructing chiral through-space luminophores via simple chlorination on bridged carbazole motifs. The chlorination breaks the molecular symmetry and thus results in molecular chirality by eliminating the mirror plane or rotating axis. Interestingly, continuous multiple chlorinations can rebuild and break the symmetry of the skeleton in succession. Several chiral and achiral isomeric analogues are synthesized and characterized with impressive chiroptical properties. Results of chiral HPLC, single-crystal X-ray diffraction, kinetic racemization, and chiroptical property investigation demonstrate the effectiveness of our rational design strategy. It provides a feasible methodology for exploring novel chiral luminescent materials based on versatile though-space skeletons.
Treatment of supraglottic squamous cell carcinoma with advance technologies: Observational prospective evaluation of oncological outcomes, functional outcomes, quality of life and cost-effectiveness (SUPRA-QoL)
Authors: Hassid Samantha , Krug Bruno , Deheneffe Stéphanie , Daisne Jean-François , Delahaut Gilles , Lawson Georges , Crott Ralph , Vorst Sébastien Van der 
Published: December 2022

Abstract
Background:
Over the past decade, therapeutic options in head and neck supraglottic squamous cell carcinoma have constantly evolved. The classical total laryngectomy has been partially replaced by alternative organ- and function-sparing techniques with the same prognosis but less morbidity, such as Radiotherapy, Transoral Laser Microsurgery (TLM) and Trans-Oral Robotic Surgery (TORS). Up to now, a prospective comparison of these innovant techniques has not been conducted.
Methods/Design:
We will conduct an original international multicentric prospective nonrandomized clinical trial to compare the efficacy between these treatments (Arm 1: Radiotherapy +/- chemotherapy; Arm 2: TLM and Arm 3: TORS) with 4 classes of outcomes: quality of life (QoL), oncological outcomes, functional outcomes and economic resources. The population will include cT1-T2 /cN0-N1/M0 supraglottic squamous cell carcinoma. The primary outcome is a Clinical Dysphagia QoL evaluation assessed by the MD Anderson Dysphagia questionnaire. Secondary outcomes include others QoL evaluation, oncological and functional measures and cost parameters. The sample size needs to reach 36 patients per arm (total 108).
Discussion:
In the current literature, no prospective head-to-head trials are available to compare objectively these different treatments. With the increase of highly efficient treatments and the increase of oncological survival, it is imperative also to develop management strategies that optimize QoL and functional results. We will conduct this innovate prospective trial in order to obtain objective data in these two main issues.
Trial Registration: NCT05611515 posted on 10/11/2022 (clinicaltrial.fgov)
Bulimia symptoms and anger and aggression among adolescents
Authors: Koposov Roman , Stickley Andrew , Sukhodolsky Denis , Ruchkin Vladislav 
Published: December 2022

Abstract
Background
Previous research has indicated that anger and aggression may be elevated in adolescents with a bulimia nervosa (BN) diagnosis. However, as yet, little is known about whether bulimia symptoms are linked to anger and aggression or if these associations exist in adolescents in the general population. To address this deficit this study aimed to explore the associations between a clinical level of bulimia symptoms (CLBS) and anger, anger rumination and aggression in community-based adolescents, and determine whether gender is important in this context.
Methods
This study was conducted on a representative sample of youth from northwestern Russia (N = 2613, age 13–17 years old, 59.5% female) using self-report scales. A proxy variable for a CLBS was created using the Eating Disorder Diagnostic Scale. Aggression, anger and anger rumination were assessed by the Trait Anger Scale of the State Trait Anger Expression Inventory, the Anger Rumination Scale, and scales created to assess physically and verbally aggressive behavior. Multivariate analysis of covariance was used to examine the associations between the study variables.
Results
A CLBS was more prevalent in girls than in boys (13.4% vs 3.5%). The association with anger and aggression was stronger in both genders with a CLBS, compared to those adolescents without a CLBS. In the CLBS group, boys as compared to girls scored higher on verbal and physical aggression, anger rumination and social aggression. In both the CLBS and Non-CLBS group higher anger and aggression scores were associated with increasing age.
Conclusions
Findings suggest that aggression and anger rumination are elevated in adolescents with BN symptoms, and that the associations between anger, aggression and BN symptoms may be stronger in boys. As previous research has indicated that the presence of aggressive behaviors may affect the prognosis of BN and complicate management of the disorder, clinician screening for these behaviors in adolescents with BN symptoms may facilitate the provision of more effective treatment, especially among boys.
Barriers and facilitators of exercise behavior for frail elderly in nursing homes: protocol for a qualitative study in China
Authors: Sunzi Kejimu , Li Yadi , Zhou Xin , Liang Ruichen , Lei Cheng 
Published: December 2022

Abstract
Background
Exercise is significant for the elderly to improve their poor health outcomes. It can delay weakness, enhance the quality of muscle and body balance, and prevent adverse events. But the factors that hinder or promote exercise among frail nursing home residents are unclear. Few studies have investigated the exercise-related experiences and coping strategies of the frail elderly, and it is necessary to understand the overall situation among the elderly further. Therefore, this study aims to obtain information about the impact of exercise-related barriers and facilitators on the daily life of frail older adults and how they cope with this condition.
Methods/Design:
Qualitative research design uses a phenomenological framework. Older adults participating in the study will be invited to describe their life experiences with exercise-related barriers and facilitators, the impact on their daily lives, and the strategies they use to cope with the condition. This study will use purposeful sampling to ensure that the sample provides informative cases representative of frail older adults with exercise-related barriers and facilitators. Face-to-face, personal and semi-structured interviews will be conducted in nursing homes in Sichuan, China. A trained qualitative person will conduct interviews. Transcripts will be analyzed using NVivo10 qualitative software, and themes will be synthesized to highlight the critical issues raised by the frail elderly about the exercise process.
Discussion
Understanding the awareness of frail older adults on exercise management care will help improve the existing health services in this area. This research data will be used in future research to develop a validated survey, which can be used by medical staff working in nursing homes to understand and strengthen the health service provision of the frail elderly.
FLI1 regulates radiotherapy resistance in nasopharyngeal carcinoma through TIE1-mediated PI3K/AKT signaling pathway
Authors: Chen Enni , Huang Jiajia , Wu Jiawei , Chen Miao , Ouyang Puyun , Wang Xiaonan , Shi Dingbo , Liu Zhiqiao , Zhu Wancui , Sun Haohui , Yang Shanshan , Zhang Baoyu , Deng Wuguo , Qiu Huijuan , xie fangyun 
Published: December 2022

Abstract
Radiotherapy resistance is the main cause of treatment failure in nasopharyngeal carcinoma (NPC), which leads to poor prognosis. It is urgent to elucidate the molecular mechanisms underlying radiotherapy resistance. Here we identified FLI1 as a potential radiosensitivity regulator which was dramatically overexpressed in the patients with progressive disease (PD) to radiotherapy compared to those with complete response (CR). We examined the effect of FLI1 on cell survival, apoptosis and γ-H2AX expression in NPC cells after radiation, and found that FLI1 induced radiotherapy resistance and enhanced the ability of DNA damage repair in NPC cells. We also confirmed the role of FLI1 in regulating radiotherapy resistance in vivo using the nude mouse NPC xenograft model. Moreover, we demonstrated that FLI1 upregulated the transcription of TIE1 by binding to its promoter. The rescue experiment further confirmed that FLI1 activated the PI3K/AKT signaling pathway by upregulating TIE1, thereby affecting radiotherapy sensitivity of NPC cells. Furthermore, we showed that NPC patients with high levels of FLI1 and TIE1 were correlated with poor prognosis. Together, our study has revealed that FLI1 regulates radiotherapy resistance of NPC through TIE1-mediated PI3K/AKT signaling pathway, suggesting that targeting the FLI1/TIE1 signaling pathway could be a potential therapeutic strategy to enhance the efficacy of radiotherapy in NPC.
A Prospective Cross-sectional Study to Evaluate retina developing via OCTA based on school students in Qamdo, Tibet, China
Authors: Sun Kexin , Xiang Yongguo , Zhang Tong , Yi Shenglan , Xia Jiuyi , Yang Xin , Zheng Shijie , Ji Yan , Hu Ke , Wan Wenjuan 
Published: December 2022

Abstract
Aims

To estimate the microstructure in different ages school students using optical coherence tomography angiography (OCTA) in Qamdo.

Design

A prospective cross-sectional, school-based research.

Methods

This study includes 347 normal students from 9 schools in 4 different areas in Qamdo. Macular region 3×3 area and macular cube 512×128 showed details in macular by OCTA images. Using ETDRS Vessel Flow Density module measure Central vascular plexus density (CVD), Inner vascular plexus density (IVD), Full vascular plexus density (FVD) or the size of foveal avascular zone (FAZ). These differences were compared among various ages, sexes and living environments.

Result

The mean FAZ area in all eyes was 0.29 ± 0.13 mm2. The Mean Foveal Thickness in the macular cube (MFT) was 239.81 ± 19.13 µm. It did not show a significant relationship between FAZ areas and sex (p = 0.011), age (p = 0.1736) or others (MFT, altitude). Compared with girls, boys had a lager MFT (p < 0.001). Among the different age groups, MFT (p < 0.001) and FVD (p < 0.001), IVD (p < 0.001) increased with age.

Conclusion

OCT-A can use to evaluate macular perfusion in children. Our data bridge the gap between structural OCT and perfusion density in children in high altitude. Even though not a longitudinal study, it also provides us some information about retina developing in teenagers OCTA’s clinical implications.
Metagenomic analysis reveals specific BTEX degrading microorganisms of a bacterial consortium
Authors: Wu Hui-jun , Du Xian-yuan , Wu Wen-jing , Zheng Jin , Song Jia-yu , Xie Jia-cai 
Published: December 2022

Abstract
Petroleum hydrocarbon contamination is of environmental and public health concerns due to its toxic components. Bioremediation utilizes microbial organisms to metabolism and remove these contaminants. The aim of this study was to enrich a microbial community and examine its potential to degrade petroleum hydrocarbon. Through successive enrichment, we obtained a bacterial consortium using crude oil as sole carbon source. The 16S rRNA gene analysis illustrated the structural characteristics of this community. Metagenomic analysis revealed the specific microbial organisms involved in the degradation of cyclohexane and all the six BTEX components, with a demonstration of the versatile metabolic pathways involved in these reactions. Results showed that our consortium contained the full range of CDSs that could potentially degrade cyclohexane, benzene, toluene, and (o-, m-, p-) xylene completely. Interestingly, a single taxon that possessed all the genes involved in either the activation or the central intermediates degrading pathway was not detected, except for the Novosphingobium which contained all the genes involved in the upper degradation pathway of benzene, indicating the synergistic interactions between different bacterial genera during the hydrocarbon degradation.
Green Capital and Green Jobs:
What Does Transition to Green Economy Look Like?
Authors: Shayegh Soheil , Roshan Elnaz 
Published: December 2022

Abstract
Transition to green economy is urgently needed in order to reach the climate targets by the end of this century. We investigate the optimal pathways for transitioning of the global economy from one dominated by the fossil-fueled (brown) sector to one dominated by the zero-emission (green) sector. We consider three transition regimes: a "Linear" regime with a constant growth rate of the green sector, a "Delayed" regime composed of a much lower early growth rate until 2050 followed by a higher growth rate afterwards, and a "Fast" regime composed of a much higher early growth rate until 2050 followed by a slower growth rate afterwards. Our results indicate that the labor market is more sensitive to the pace of transition than the capital market. We also find that slow green growth under the "Delayed" regime induces higher rates of abatement in the brown sector which are amplified by early R&D investment in green capital productivity. Finally, we show that rapid transition to green economy requires substantial upfront investment in renewable energy infrastructure and human capital development which in turn, reduces greenhouse gas emissions by 60% in 2050 compared to the "Delayed" regime.
Uncovering hidden spin polarization of energy bands in antiferromagnets
Authors: Yuan Lin-Ding , Zhang Xiuwen , Acosta Carlos Mera , Zunger Alex 
Published: December 2022

Abstract
Many textbook physical effects in crystals are enabled by some specific symmetries. In contrast to such ‘apparent effects’, ‘hidden effect X’ refers to the general condition where the nominal global system symmetry would disallow the effect X, whereas the symmetry of local sectors within the crystal would enable effect X. Known examples include the hidden Rashba and/or hidden Dresselhaus spin polarization that require spin orbit coupling, but (unlike the apparent Rashba and Dresselhaus counterparts) can exist even in inversion-symmetric non-magnetic crystals. Here we point out that the spin splitting effect that does not require spin-orbit coupling (SOC) can have a hidden spin polarization counterpart in antiferromagnets. We show that such hidden, SOC-independent effects reflect intrinsic properties of the perfect crystal rather than an effect due to imperfections, opening the possibility for experimental realization, and offering a potential way to switch antiferromagnetic ordering.
The Burnout Process Among Hungarian Teachers analysed in a cross-sectional study: The Burnout Process Questionnaire
Authors: Szigeti Réka , Balázs Noémi , Urbán Róbert 
Published: December 2022

Abstract
Background
Studies have focused more on the outcome than on the process of burnout. However, different teachers at different stages of the process may be present at the same time, which the current methods do not capture. We aimed to develop a new measurement tool for the burnout process among teachers based on grounded theory.
Methods
In this cross-sectional study we tested the Burnout Process Questionnaire on a convenience sample of teachers (n = 618, 83.9% women; mean age 44.52 years). We used confirmatory factor analyses to test our measurement model. We examined the concurrent validity with the burnout factors the Maslach Burnout Inventory questionnaire includes. We tested construct validity with depression, overcommitment, demographic characteristics and work-related factors.
Results
The confirmatory factor analyses supported our measurement model with seven primary factors (need to prove oneself, overload of tasks, neglecting one’s needs, conflict between values, interpersonal conflicts, passivity, and emotional drain) and three second-order factors (excessive effort, conflict, and total depletion). The covariates in the Maslach Burnout Inventory showed that emotional exhaustion had a strong relationship with the first- and second-order factors. Overcommitment showed a stronger relationship with factors at the beginning whereas depression showed a stronger relationship with factors at the end of the process. Demographic characteristics and work-related factors did not show strong associations.
Conclusions
The Burnout Process Questionnaire is a promising measurement tool with good convergent validity. It adds a new dimension to the measurement of burnout. The process approach to measuring burnout among teachers can guide future research and tailored prevention programs.