bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early-Stage Lung Cancer Patients’ Perceptions of Presurgical Discussions
Authors: Schwartz Rebecca M. , Yip Rowena , You Nan , Gillezeau Christina , Song Kimberly , Yankelevitz David F. , Taioli Emanuela , Henschke Claudia I. , Flores Raja M. ,   for the IELCART Investigators
Published: March 2022

Background Patients with early-stage non–small-cell lung cancer (NSCLC) have high survival rates, but patients often say they did not anticipate the effect of the surgery on their postsurgical quality of life (QoL). This study adds to the literature regarding patient and surgeon interactions and highlights the areas where the current approach is not providing good communication. Design Since its start in 2016, the Initiative for Early Lung Cancer Research on Treatment (IELCART), a prospective cohort study, has enrolled 543 patients who underwent surgery for stage I NSCLC within the Mount Sinai Health System. Presurgical patient and surgeon surveys were available for 314 patients, postsurgical surveys for 420, and both pre- and postsurgical surveys for 285. Results Of patients with presurgical surveys, 31.2% said that their surgeon recommended multiple types of treatment. Of patients with postsurgical surveys, 85.0% felt very well prepared and 11.4% moderately well prepared for their postsurgical recovery. The median Functional Assessment of Cancer Therapy–Lung Cancer score and social support score of the patients who felt very well prepared was significantly higher than those moderately or not well prepared (24.0 v. 22.0, P < 0.001) and (5.0 [interquartile range: 4.7–5.0] v. 5.0 [IQR: 4.2–5.0], p = 0.015). Conclusions This study provides insight into the areas where surgeons are communicating well with their patients as well as the areas where patients still feel uninformed. Most surgeons feel that they prepare their patients well or very well for surgical recovery, whereas some patients still feel that their surgeons did not prepare them well for postsurgical recovery. Surgeons may want to spend additional time emphasizing postsurgical recovery and QoL with their patients or provide their patients with additional avenues to get their questions and concerns addressed. Highlights Pretreatment discussions could help surgeons understand patient priorities and patients understand the anticipated outcomes for their surgeries. There is an association between feeling prepared for surgery and higher quality of life and social support scores after adjustment for confounders. Despite these pretreatment discussions, patients still feel that they are not well prepared about what to expect during their postsurgical recovery.
Guite, the spinel-structured Co2+Co3+2O4, a new mineral from the Sicomines copper–cobalt mine, Democratic Republic of Congo
Authors: Lei Zhilan , Chen Xinghai , Wang Jianxiong , Huang Yingchun , Du Fangfang , Yan Zier 
Published: March 2022

AbstractGuite (IMA2017-080), Co3O4, is a new mineral species and an important economic mineral found in the Sicomines copper-cobalt mine, located ~11 km southwest of Kolwezi City, Democratic Republic of Congo. The mineral occurs as a granular agglomerate, 50 to 500 μm in size, and is associated closely with heterogenite in a quartz matrix. Guite is opaque, has a dark grey colour with metallic lustre and a black streak. In reflected light microscopy, it is white with no internal reflections. The reflectance values (in air,Rin %) are: 27.0 (470 nm); 25.6 (546 nm); 25.2 (589 nm), and 24.6 (650 nm). The average of 20 electron-microprobe analyses is Co 71.53, Cu 0.58, Mn 0.67, Si 0.25, O 26.78, total 99.82 wt.%, corresponding to the empirical formula calculated on the basis of 4 O apfu: (Co2+0.92Cu2+0.02Si4+0.02)Σ0.96(Co3+1.98Mn3+0.03)Σ2.01O4.00, with Co2+and Co3+partitioned using charge balance. The ideal formula is Co2+Co3+2O4. Guite is cubic with space groupFd$\bar{3}$m. The unit cell parameters refined from the single crystal X-ray diffraction data are:a= 8.0898(1) Å,V= 529.436(11) Å3andZ= 8. The calculated density of guite is 6.003 g/cm3. The eight strongest observed powder X-ray diffraction lines [din Å (I/I0) (hkl)] are: 4.6714 (16.7) (111), 2.8620 (18.4) (220), 2.4399 (100) (311), 2.3348 (10.4) (222), 2.0230 (24.8) (400), 1.5556 (26.3) (511, 333), 1.4296 (37.7) (440) and 1.0524 (10.1) (731, 553). The crystal structure of guite was determined by single-crystal X-ray diffraction and refined toR= 0.0132 for 3748 (69 unique) reflections. Guite has a typical spinel-type structure with Co2+in tetrahedral coordination with a Co2+–O bonding length of 1.941(1) Å, and Co3+in octahedral coordination with a Co3+–O bonding length of 1.919(1) Å. The structure is composed of cross-linked framework of chains of Co3+–O6octahedra sharing the equilateral triangle edges (2.550 Å) in three directions [0 1 1], [1 1 0], [1 0 1] with Co2+filling the tetrahedral interstices among the chains. Guite is named in honour of Prof. Xiangping Gu (1964–).
Targeting platelet-derived CXCL12 impedes arterial thrombosis
Authors: Leberzammer Julian , Agten Stijn M. , Blanchet Xavier , Duan Rundan , Ippel Hans , Megens Remco T. A. , Schulz Christian , Aslani Maria , Duchene Johan , Döring Yvonne , Jooss Natalie J. , Zhang Pengyu , Brandl Richard , Stark Konstantin , Siess Wolfgang , Jurk Kerstin , Heemskerk Johan W. M. , Hackeng Tilman M. , Mayo Kevin H. , Weber Christian , von Hundelshausen Philipp 
Published: March 2022

Abstract
The prevention and treatment of arterial thrombosis continue to be clinically challenging, and understanding the relevant molecular mechanisms in detail may facilitate the quest to identify novel targets and therapeutic approaches that improve protection from ischemic and bleeding events. The chemokine CXCL12 augments collagen-induced platelet aggregation by activating its receptor CXCR4. Here we show that inhibition of CXCR4 attenuates platelet aggregation induced by collagen or human plaque homogenate under static and arterial flow conditions by antagonizing the action of platelet-secreted CXCL12. We further show that platelet-specific CXCL12 deficiency in mice limits arterial thrombosis by affecting thrombus growth and stability without increasing tail bleeding time. Accordingly, neointimal lesion formation after carotid artery injury was attenuated in these mice. Mechanistically, CXCL12 activated via CXCR4 a signaling cascade involving Bruton’s tyrosine kinase (Btk) that led to integrin αIIbβ3 activation, platelet aggregation, and granule release. The heterodimeric interaction between CXCL12 and CCL5 can inhibit CXCL12-mediated effects as mimicked by CCL5-derived peptides such as [VREY]4. An improved variant of this peptide, i[VREY]4, binds to CXCL12 in a complex with CXCR4 on the surface of activated platelets, thereby inhibiting Btk activation and preventing platelet CXCL12-dependent arterial thrombosis. In contrast to standard antiplatelet therapies such as aspirin or P2Y12 inhibition, i[VREY]4 reduced CXCL12-induced platelet aggregation and yet did not prolong in vitro bleeding time. We provide evidence that platelet-derived CXCL12 is involved in arterial thrombosis and can be specifically targeted by peptides that harbor potential therapeutic value against atherothrombosis.
Investigation of empty container shortage based on SWARA-ARAS methods in the COVID-19 era
Authors: Toygar Arda , Yildirim Umut , İnegöl Gani Mustafa 
Published: March 2022

AbstractA shortage of empty containers has become a global crisis with more devastating effects than during previous periods when combined with various problems arising from the COVID-19, such as an increase in an imbalance of global trade between supply and demand, a decrease in the workforce, and restrictions by countries or regional quarantine practices. The absence of empty containers in regions where they are needed slows down industrial activities and locks the global supply networks, necessitating the use of alternative methods that are inefficient. Although this shortage causes many disruptions in global trade, solutions to the issue have not been studied in detail. Therefore, the aim of this study was to determine the issues caused by the shortage of empty containers and to rank the appropriate solutions. Four main criteria and sixteen subcategories used to define the issues, as well as a multi criteria decision model comprising five criteria for the solutions, were proposed based on information from the literature, sectorial publications, and expert opinions. The issues’ weighted order of importance in our proposed model was calculated using the SWARA (Step-wise Weight Assessment Ratio Analysis) method; solutions were ranked using the ARAS (Additive Ratio Assessment) method. The results of the study revealed that the issues were ranked in importance as cost increases, uncertainty in the supply chain, volume loss, and increases in blank sailing announcements. Appropriate solutions were ranked as booking guarantee applications and information communication technologies, using shipper-owned containers, inducement calls, and E2E (end to end) delivery services.
QTL detection for bread wheat processing quality in a nested association mapping population of semi-wild and domesticated wheat varieties
Authors: Hu Junmei , Xiao Guilian , Jiang Peng , Zhao Yan , Zhang Guangxu , Ma Xin , Yao Jie , Xue Lixia , Su Peisen , Bao Yinguang 
Published: March 2022

Abstract
Background
Wheat processing quality is an important factor in evaluating overall wheat quality, and dough characteristics are important when assessing the processing quality of wheat. As a notable germplasm resource, semi-wild wheat has a key role in the study of wheat processing quality.

Results
In this study, four dough rheological characteristics were collected in four environments using a nested association mapping (NAM) population consisting of semi-wild and domesticated wheat varieties to identify quantitative trait loci (QTL) for wheat processing quality. A total of 49 QTL for wheat processing quality were detected, explaining 0.36–10.82% of the phenotypic variation. These QTL were located on all wheat chromosomes except for 2D, 3A, 3D, 6B, 6D and 7D. Compared to previous studies, 29 QTL were newly identified. Four novel QTL, QMlPH-1B.4, QMlPH-3B.4, QWdEm-1B.2 and QWdEm-3B.2, were stably identified in three or more environments, among which QMlPH-3B.4 was a major QTL. Moreover, eight important genetic regions for wheat processing quality were identified on chromosomes 1B, 3B and 4D, which showed pleiotropy for dough characteristics. In addition, out of 49 QTL, 15 favorable alleles came from three semi-wild parents, suggesting that the QTL alleles provided by the semi-wild parent were not utilized in domesticated varieties.

Conclusions
The results show that semi-wild wheat varieties can enrich the existing wheat gene pool and provide broader variation resources for wheat genetic research.
Association between early detected heart failure stages and future cardiovascular and non-cardiovascular events in the elderly (Copenhagen Heart Failure Risk Study)
Authors: Parveen Saaima , Zareini Bochra , Arulmurugananthavadivel Anojhaan , Kistorp Caroline , Faber Jens , Køber Lars , Hassager Christian , Sørensen Tor Biering , Andersson Charlotte , Zahir Deewa , Iversen Kasper , Wolsk Emil , Gislason Gunnar , Gaborit Freja , Schou Morten 
Published: March 2022

Abstract
Background
Early stages of heart failure (HF) are associated with an increased risk of hospitalization and increased mortality, however the course of progression and the impact of non-cardiovascular comorbidities on adverse events in elderly high-risk patients are unknown.

Aim
To examine the risk of future cardiovascular (CV) and non-CV events in early stages of HF in a cohort of elderly patients (age ≥ 60 with ≥ 1 risk factor for HF and without known or clinically suspected HF).

Methods
A total of 400 patients (American Heart Association HF stage A: N = 177; stage B: N = 150; stage C: N = 73) from the Copenhagen Heart Failure Risk Study were identified and followed for the main composite outcome of a HF hospitalization (HFH), ischemic heart disease (IHD), stroke, and all-cause death, recorded within the Danish nationwide registries. Non-CV hospitalization was a secondary outcome. Absolute risk was calculated by the Aalen-Johansen estimator.

Results
The median follow-up time was 3.3 years, total number of events were 83, and the 3-year risk (95% confidence interval) of the main outcome was 12.8% (7.8–17.9), 22.8% (16.1–29.6) and 31.8% (21.0–42.6) for patients with stage A, B, and C, respectively. 1.1% (0.0–2.7), 3.4% (1.0–6.3) and 10.0% (2.8–16.3) experienced HFH as their first event, whereas 37.3% (30.2–44.4), 49.7% (41.6–57.8) and 54.8% (43.4–66.2) were admitted for non-CV causes as their first event.

Conclusion
The risk of HFH, IHD, stroke and all-cause death increased with severity of HF stage, and 10% of patients with undiagnosed HF stage C were admitted for HF within 3 years. However, the risk of non-CV hospitalizations was greater compared to the risk of experiencing HFH.
Barriers and facilitators to providing home-based care in a pandemic: policy and practice implications
Authors: Bell Sue Anne , Krienke Lydia , Brown Allyson , Inloes Jen , Rettell Zoe , Wyte-Lake Tamar 
Published: March 2022

AbstractObjectiveThe purpose of this study is to describe the experiences of home-based care providers (HBCP) in providing care to older adults during the pandemic in order to inform future disaster planning, including during pandemics.DesignQualitative inquiry using an abductive analytic approach.Setting and participantsHome-based care providers in COVID-19 hotspots.MethodsTelephone interviews were conducted with 27 participants (administrators, registered nurses and other members of the allied healthcare team), who provided in-home care during the pandemic in Medicare-certified home health agencies. Interviews focused on eliciting experiences from HBCP on challenges and successes in providing home-based care to older adults, including barriers to care and strategies employed to keep patients, and providers, safe in their homes during the pandemic.ResultsData was distilled into four major themes that have potential policy and practice impact. These included disrupted aging-in-place resources, preparedness actions contributing to readiness for the pandemic, limited adaptability in administrative needs during the pandemic and challenges with unclear messaging from public health officials.ConclusionsHome-based care plays an essential role in maintaining the health of older adults in disaster contexts, including pandemics. Innovative solutions, informed by policy that generate evidence-based best practices to support HBCP are needed to reduce barriers and increase protective factors, in order to maintain continuity of care for this vulnerable population during disruptive events.
Prior pregnancy complications and maternal cardiovascular disease in young Korean women within 10 years after pregnancy
Authors: Cho Geum Joon , Um Ji Soo , Kim Sa Jin , Han Sung Won , Lee Soo Bin , Oh Min-Jeong , Shin Jae Eun 
Published: March 2022

Abstract
Background
This study aimed to compare obstetric outcomes in Korean women with and without future cardiovascular disease (CVD) within 10 years after pregnancy, and assessed whether pregnancy complications are independent risk factors, and whether the combination of pregnancy complications has an additive function for risk factors for CVD.

Methods
This was a nationwide population-based study combining the database of the Korea National Health Insurance claims and National Health Screening Programs to assess preeclampsia, low birth weight (LBW), and preterm delivery as risk factors for CVD. Cox proportional hazards models was used to evaluate the risk of total CVD, ischemic heart disease (IHD), and stroke after the pregnancy complications, with adjustment for potential confounding variables.

Results
Women with CVD were likely to have a higher prevalence of pregnancy complications than women without CVD. The risk of total CVD was associated with preeclampsia (adjusted hazard ratio (HR), 1.60 [95% confidence interval (CI) 1.50–1.72]), LBW (1.20 [1.12–1.28]), and preterm delivery (1.32 [1.22–1.42]), after adjustment for confounders, including cardiovascular risk factors before pregnancy. The risk estimates of pregnancy complications for IHD were higher than those for stroke. In this study, the risk of total CVD was higher in the combined presence of preeclampsia and preterm delivery (2.23 [1.57–3.17] or all three complications (2.06 [1.76–2.40]), relative to no complications. The highest HR was noted in the risk of all pregnancy complications for IHD (2.39 [1.98–2.89]).

Conclusion
Preeclampsia, preterm delivery, and LBW were independently associated with CVD in young Korean women. In addition, the combination of pregnancy complications had less-than-additive effects on CVD incidence.
Previous exposure to antipsychotic drug treatment is an effective predictor of metabolic disturbances experienced with current antipsychotic drug treatments
Authors: Yang Ye , Xie Peng , Long Yujun , Huang Jing , Xiao Jingmei , Zhao Jingping , Yue Weihua , Wu Renrong 
Published: March 2022

Abstract
Background
Antipsychotic drugs are associated with adverse events, but serious side effects are not frequent. This study aimed to ascertain whether previous exposure to antipsychotic treatment was associated with metabolic disturbances induced by current antipsychotic medication.

Methods
A total of 115 antipsychotic-naïve patients, 65 patients with previous exposure to low-metabolic-risk antipsychotics, and 88 patients with previous exposure to high-metabolic-risk antipsychotics were enrolled in our case-control study. All patients were administered olanzapine. Body weight, body mass index (BMI), biochemical indicators of blood glucose and lipids, the proportion of patients who gained more than 7% of their body weight at baseline, and the percentage of dyslipidemia were evaluated. All assessments were conducted at baseline and at 4 and 6 weeks after treatment.

Results
Olanzapine treatment resulted in a significant increase in body weight and BMI in antipsychotic-naïve patients compared with the other two groups (both p < 0.05). However, increases in lipid levels in the high-metabolic-risk antipsychotics group were significantly higher than that in the other two groups (both p < 0.05). A history of antipsychotics use was not associated with weight gain (all p > 0.05). Higher low-density lipoprotein cholesterol ≥3.37 mmol/L–1 was observed in antipsychotics exposure group compared with no history of antipsychotics exposure (aOR, 1.75; 95% CI, 1.07-3.52). Particularly, a history of high-metabolic-risk antipsychotics use was associated with a higher risk of LDL-C ≥3.37 mmol/L–1(aOR, 2.18; 95% CI, 1.03-3.32) compare with other two groups.

Conclusions
A history of exposure to antipsychotics, particularly high-metabolic-risk antipsychotics, is associated with current antipsychotic-induced metabolic disturbances.
Radial arteriovenous fistula complicated with ischemic steal syndrome after transradial cardiac catheterization: a case report and literature review
Authors: Gu Fengming , Yu Jiong , Mi Jingyi 
Published: March 2022

Abstract
Background
The radial arteriovenous fistula (AVF) is a rare complication occurring after transradial cardiac catheterization. Patients with AVF typically present with signs of venous dilation, such as swelling or palpable thrills. However, neurological complications secondary to radial AVFs are rare. This paper reported a rare case of ischemic steal syndrome that occurred 11 months after the transradial cardiac catheterization, most likely as a consequence of radial arteriovenous fistula.

Case presentation
This paper described a case of a 73-year-old female, who complained of right forearm swelling and radial 1–3 fingers numbness for several months after the catheterized stent surgery through radial approach. Upon Clinical examination, this patient presented with a slight bump and palpable thrill at the distal third of right forearm, and the sensory of radial 1–3 fingers and pinch force was compromised. The Ultrasonography and computed tomography angiography (CTA) of the upper extremity revealed AVF between the right radial artery and the adjacent vein. Microsurgery was performed successfully to ligate the fistula and reconstruct the radial artery. The numbness has gradually improved about 1 week after the surgery, with no recurred swelling. The two-point pinch force and digital sensitivity recovered at the 20-month follow-up. What’s more, due to the scarcity of cases, the optimal therapy for iatrogenic radial AVF is controversial. Accordingly, we provided a literature review of previous reports of catheter-related radial AVFs and proposed an algorithm to manage them.

Conclusions
We believe that once an AVF is diagnosed, early treatment options such as compression or surgery are necessary to relieve symptoms and prevent further complications. Otherwise, serious complications can occur, including the ischemic steal syndrome.
Tumour site is a risk factor for hepatocellular carcinoma after hepatectomy: a 1:2 propensity score matching analysis
Authors: Li Lian , Xu Liangliang , Zhou Siqi , Wang Peng , Zhang Ming , Li Bo 
Published: March 2022

Abstract
Background
The effect of the anatomic location of HCC on the prognosis of patients after hepatectomy is currently unclear.

Methods
Patients who underwent hepatectomy were retrospectively enrolled and divided into the right tumour resection group (R group) and the left tumour resection group (L group) according to the tumour anatomic location. To avoid bias, 1:2 propensity score matching (PSM) analysis was used. Based on the survival data, disease-free survival (DFS) and overall survival (OS) were evaluated by the Kaplan–Meier method, and long-term survival analysis was performed. Cox proportional hazards regression was used to analyse the risk factors associated with postoperative prognosis.

Results
A total of 700 patients were enrolled in our study. After 1:2 PSM, 354 and 177 patients were enrolled in the R group and the L group, respectively, with comparable baseline characteristics. Survival analysis showed that patients in the L group had a significantly higher recurrence rate than patients in the R group (P = 0.036), but there was no significant difference in the survival rate (P = 0.99). Long-term survival analysis showed that the survival rate of the L group was lower than that of the R group (P < 0.01). Multivariate analysis showed that tumour location in the left liver was an independent risk factor for tumour recurrence (hazard ratio, 1.263; 95% CI, 1.005–1.587) and long-term survival (hazard ratio, 3.232; 95% CI, 1.284–8.134).

Conclusion
For HCC patients, the recurrence rate and long-term survival rate of left liver tumours were significantly higher than those of right liver tumours, indicating that the anatomical location of the tumour has a significant effect on the survival of HCC patients.
Trial registration Chinese Clinical Trial Registry, ChiCTR2100052407. Registered 25 October 2021, http://www.chictr.org.cn/showproj.aspx?proj=135500.