bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adubação orgânica na produção de massa seca e acúmulo de nutrientes em plantas de jambu
Authors: Nordi Nicholas Taborda , Alves Thatiane Nepomuceno , Cardoso Antonio Ismael Inácio , Moraes Vinícius Pereira de , Carvalho Joseantonio Ribeiro de 
Published: June 2022

O objetivo desse trabalho foi avaliar adubos orgânicos na produção de matéria seca e acúmulo de macronutrientes em plantas de jambu. Os experimentos foram conduzidos na Fazenda Experimental de São Manuel, SP, pertencente à Faculdade de Ciências Agronômicas (FCA) - UNESP e no sítio Zodíaco, situado no bairro Demétria, município de Botucatu, SP. Foram avaliados seis tratamentos, adubos em cobertura, sendo eles, ferticel®, provaso®, torta de mamona, bokashi, farinha de casco e chifre e um controle sem cobertura, em cinco repetições, utilizando delineamento em blocos casualizados. Foram avaliados massa da matéria seca e acúmulo de macronutrientes nas inflorescências, parte vegetativa e parte aérea (inflorescências + parte vegetativa), em duas colheitas em cada área. Em relação a massa da matéria seca, o adubo casco e chifre resultou em maiores valores, 444,5; 322,5 g m-2; 1286,8; 540 g m-2; e 1730,8 e 860 g m-2 nas inflorescências, parte vegetativa e parte aérea, no sítio Zodíaco e na fazenda São Manuel, respectivamente. A ordem decrescente de acúmulo de nutrientes (g m-2) na parte aérea das plantas no sítio Zodíaco foi: K (54,37) > N (27,2) > Ca (7,4) > Mg (5,9) > P (4,8) > S (4,6), enquanto na Fazenda São Manuel foi K (23,25) > N (11,4) > Ca (5,3) > P (3,5) > Mg (2,3) > S (1,7).
Eleições 2020: O que os candidatos à prefeitura propuseram para o meio ambiente?
Authors: Alves Guilherme Prado , Almeida Maria Rita Raimundo e , Bucci Maria Elisa Diniz 
Published: June 2022

O processo eleitoral é um momento decisivo na criação, encerramento ou continuidade de práticas relacionadas à agenda socioambiental. Assumindo a relevância deste contexto, este trabalho tem como objetivo avaliar como a questão ambiental foi contemplada nas propostas de governo dos candidatos a prefeitos nas eleições de 2020. Foram selecionadas aleatoriamente três cidades para avaliação, mas representando uma faixa populacional específica (cidades pequena, média e grande). Foi desenvolvido um método que avalia a abordagem relacionada ao meio ambiente dos planos de governo dos candidatos à prefeitura, sendo utilizadas nove categorias (gestão de resíduos sólidos, gestão de recursos hídricos, saneamento básico, qualidade do ar, mudanças climáticas, áreas verdes, biodiversidade, desenvolvimento sustentável e educação ambiental). As categorias foram definidas de forma interativa, a partir da literatura científica em gestão ambiental e políticas públicas e a leitura dos planos de governo. Cada categoria foi avaliada em uma escala de 0 a 3, tendo cada plano uma nota final representada pelo somatório das notas das categorias. A abordagem da questão ambiental nos planos de governo mostrou-se bastante limitada e aquém da necessária. Quatro planos não fizeram referência nenhuma ao meio ambiente e as categorias menos mencionadas foram qualidade do ar, mudanças climáticas e biodiversidade. Em alguns casos, as propostas demonstraram ser de interesse eleitoral e talvez não representem uma preocupação ambiental legítima. Este estudo não abordou questões político-partidárias ou a concretude das propostas, sendo estes campos potenciais para o desenvolvimento de trabalhos futuros.
Pelatihan Penguatan Pembelajaran Online Berbasis Edmodo Pada SMAN 12 Kota Jambi
Authors: Amalia Shynta , Nurhasanah Amalia , Fitria Wahyuni , Mahmudah Faiqah , Andriani Reni , Zurnelly Netty 
Published: June 2022

Kegiatan Pengabdian kepada Masyarakat dengan tema “Pelatihan Persiapan Pembelajaran Online Berbasis Edmodo” ini merupakan kegiatan kolaborasi antara beberapa dosen Prodi Tadris Bahasa Inggris UIN Sulthan Thaha Saifuddin Jambi dengan mahasiwa prodi yang dilaksanakan sebagai satu bentuk tindak lanjut kerjasama antara Prodi Tadris Bahasa Inggris Fakultas Tarbiyah dan Keguruan UIN Sulthan Thaha Saifuddin Jambi dengan SMAN 12 Kota Jambi. Kegiatan utama dalam program pengabdian kepada masyarakat ini ialah pelatihan pemanfaatan aplikasi Edmodo yang dapat digunakan sebagai media guru memberikan materi maupun membuat kuis atau ulangan bagi siswa secara interaktif sehingga menarik minat siswa. Sejumlah 60 guru mengikuti pelatihan interaktif ini. Pada akhir kegiatan ditemukan guru-guru memiliki persepsi yang positif terhadap kegiatan yang diberikan. Sebanyak 73% guru-guru yang mengikuti pelatihan menyampaikan bahwa kegiatan pengabdian yang dilaksanakan memberikan sesuai dengan kebutuhan peserta.
ANALISIS FORECASTING DALAM PERKEMBANGAN KINERJA KEUANGAN PADA BPRS HARTA INSAN KARIMAH CIBITUNG PERIODE 2013-2020
Authors: Aliyah Lia Hikmatul , Putra Purnama 
Published: June 2022

This research Analysis Forecasting in the Development of Financial Performance At BPRS Harta Insan Karimah Cibitung Period 2013-2020. Sharia People's Financing Bank Harta Insan Karimah Cibitung is as research object because This bank has a fairly good financial performance every year. By analyzing the existing financial ratios at BPRS Harta Insan Karimah Cibitung that is Return On Asset, Operating Expenses to Operating Income and Net Profit Margin to know the shortcomings in the past to be better in the future. The methode used in this research processing is quantitative method. The data consist of secondary data The data obtained are not directly from additional information or data used in the form of journals, websites, and other data related to research. Data analysis method using trend analysis Least Square Method.
Based on the results of the study, it is known that the development of financial ratios in the next five years will begin year 2021-2025 (quarterly) predicted on the ratio Return On Asset (ROA), that is predicted at year 2021 average of 3,99%, year 2022 decreased average of 3,95%, year 2023 decreased average of 3,91%, at year 2024 decreased average of 3,87%, at year 2025 decreased average of 3,83%. While Financial performance Operational burden on Operational Income, that is increasing every year. In the year of 2021 average of 40,28%, at year 2022 increased by 40,92%, at year 2023 increased by 41,56%, at yaer 2024 increased by 42,20%, at year 2025 increased by 42,84%. While Financial performance analysis forecasting Net Profit Margin (NPM), that is predicted at year 2021 average of 17,21%, year 2022 decreased average of 15,73%, year 2023 decreased average of 14,25%, at year 2024 decreased average of 12,77%, at year 2025 decreased average of 12,29%
Pemanfaatan Mesin Peniris Minyak Untuk Meningkatkan Kualitas Keripik Kelompok Jaya Makmur
Authors: Putri Ratna Ika , M. Rifa'i  , Yulianto  , Ari Murtono  , Bambang Priyadi  
Published: June 2022

Kelompok Jaya Makmur Desa Ploso Kecamatan Selopuro, Kabupaten Blitar selaku mitra pengabdian kepada masyarakat Polinema, mengembangkan olahan keripik belut untuk meningkatkan penghasilan keluarga sejak tahun 2019. Proses pembuatan keripik belut dilakukan secara manual melalui beberapa tahapan yaitu pembersihan dan pencucian belut, pemipihan belut, pemberian bumbu dan penggorengan. Mitra belum menggunakan mesin peniris minyak atau mesin spinner sehingga pada proses pengolahan keripik setelah digoreng masih banyak sisa minyak pada keripik belut. Hal ini menyebabkan keripik belut tersebut tidak tahan lama. Lebih dari seminggu akan hilang kerenyahannya dan berbau tengik. Tujuan dari kegiatan ini adalah memberikan pemahaman, pengetahuan dan ketrampilan mengenai pemanfaatan mesin peniris minyak untuk meningkatkan kualitas dan nilai jual produk. Metode yang digunakan yaitu inovasi teknologi tepat guna melalui pembuatan mesin peniris minyak, pelatihan dan pembinaan serta monitoring dan evaluasi kegiatan. Pelatihan dan pembinaan dilakukan melalui kegiatan sosialisasi pemanfaatan mesin peniris minyak dan praktek penggunaan dan perawatan sistem mesin peniris minyak. Setelah kegiatan PPM ini dilaksanakan secara keseluruhan, mitra mendapatkan mesin peniris minyak dan memiliki ketrampilan untuk menggunakan mesin peniris tersebut.
The Antimicrobial Potency of White Turmeric (Curcuma ceasia) in Breadfruit Starch (Artocarpus altilis) Edible Film
Authors: Suhartatik Nanik , Merkuria Karyantina  , Crisdyana Eko Setyaningsih  
Published: June 2022

Breadfruit starch contains a relatively high number of amylose which has potency to be develop as edible film. It is also necessary to develop packaging materials which also contain natural antimicrobial compounds. White turmeric contains phytochemical compounds that have antimicrobial activity. This study aimed to determine the optimal concentration of breadfruit starch in edible films and to study the effect of white turmeric extract addition to inhibit the growth of Eschericia coli and Staphylococcus aureus. The study used factorial completely randomized design which consist of 2 factors and two fold replication, namely the concentration of breadfruit starch and the concentration of white turmeric extract. The results showed that breadfruit starch at 8% concentration produce good edible film with a tensile strength reach up to 4.57 ± 0.135 MPa. Meanwhile the addition of 2.5% white turmeric could inhibit the growth of tested bacteria. Inhibition zone reached 1.38 cm for E. coli and 1.40 cm for S. aureus. White turmeric has the potency to be developed as a natural antimicrobial compound in breadfruit starch edible films.
Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design
Authors: Wang Yunze , Lin Qingyu , Shi Hongcheng , Cheng Dengfeng 
Published: June 2022

The positron emission tomography (PET) molecular imaging technology has gained universal value as a critical tool for assessing biological and biochemical processes in living subjects. The favorable chemical, physical, and nuclear characteristics of fluorine-18 (97% β+ decay, 109.8 min half-life, 635 keV positron energy) make it an attractive nuclide for labeling and molecular imaging. It stands that 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) is the most popular PET tracer. Besides that, a significantly abundant proportion of PET probes in clinical use or under development contain a fluorine or fluoroalkyl substituent group. For the reasons given above, 18F-labeled radiotracer design has become a hot topic in radiochemistry and radiopharmaceutics. Over the past decades, we have witnessed a rapid growth in 18F-labeling methods owing to the development of new reagents and catalysts. This review aims to provide an overview of strategies in radiosynthesis of [18F]fluorine-containing moieties with nucleophilic [18F]fluorides since 2015.
Silver Nanoparticle Films Obtained by Convective Self-Assembly for Surface-Enhanced Raman Spectroscopy Analyses of the Pesticides Thiabendazole and Endosulfan
Authors: Brezestean I. A. , Tosa N. , Falamas A. , Cuibus D. , Muntean C. M. , Bende A. , Cozar B. , Berghian-Grosan C. , Farcău C. 
Published: June 2022

Pesticides pose a great threat to human health and their rapid detection has become an urgent public safety issue engaging the scientific community to search for fast and reliable detection techniques. In this context, Surface Enhanced Raman Spectroscopy (SERS) has emerged as a valuable detection and analysis tool due to its high sensitivity and selectivity, proving its suitability for the food industry and environmental monitoring applications. Here, we report on the fabrication of colloidal silver nanoparticle (AgNP) films by convective self-assembly (CSA) on solid planar substrate and their use for the SERS analyses of two types of pesticides, the fungicide thiabendazole (TBZ) and the insecticide α-endosulfan (α-ES). Electron microscopy shows that these nanoparticle films are dense, highly compact, and uniform across several mm2 areas. The SERS efficiency of the fabricated AgNP films is evaluated using a well-known Raman probe, p-aminothiophenol, for multiple excitation laser lines (532 nm, 633 nm, and 785 nm). The films exhibit the largest SERS enhancement factors for 785 nm excitation, reaching values larger than 105. Thiabendazole could be readily adsorbed on the AgNPs without any sample surface functionalization and detected down to 10−6 M, reaching the sub-ppm range. Endosulfan, a challenging analyte with poor affinity to metal surfaces, was captured near the metal surface by using self-assembled alkane thiol monolayers (hexanethiol and octanethiol), as demonstrated by the thorough vibrational band analysis, and supported by density functional theory (DFT) calculations. In addition, principal component analysis (PCA) based on SERS spectra offers significant leverage in discrimination of the molecules anchored onto the metallic nanostructured surface. This present study demonstrates the utility of self-assembled colloidal nanoparticle films as SERS substrates for a broad range of analytes (para-aminothiophenol, thiabendazole, α-endosulfan, and alkanethiols) and contributes to the development of SERS-based sensors for pesticides detection, identification and monitoring.
Effect and Mechanism of Bifidobacterium animalis B94 in the Prevention and Treatment of Liver Injury in Rats
Authors: Zhang Tianfang , Wang Jie , Yao Zhao , Ni Lingmei , Zhao Yifan , Wei Shuang , Chen Zuobing 
Published: June 2022

ObjectiveTo investigate the effect of Bifidobacterium animalis B94 on the prevention and treatment of liver injury in rats and to elucidate the underlying mechanism of this relationship.MethodsSpecific pathogen-free (SPF) rats were selected as the healthy control group, liver injury group and B94 treatment group, with 6 rats in each group. After the model was established, the experimental animals were tested for serum liver function indicators, gut microbiota composition, metabolite composition, and histopathology.ResultsThe albumin/globulin ratio and serum TBA, alanine aminotransferase, aspartate aminotransferase, and indirect bilirubin levels in the B94 treatment group were significantly lower than those in the liver injury group. 16S rRNA analysis showed that the gut microbiota of the three groups of rats were significantly different. Metabolic profile analysis showed that there were significant differences in the gut metabolomes of the three groups. Haematoxylin–eosin staining of the intestinal mucosa and liver tissues showed that the degree of liver and intestinal tissue damage in the B94 treatment group was significantly lower than that in the liver injury group.ConclusionBifidobacterium animalis B94 can affect the process of liver injury in rats by improving liver function, reducing intestinal damage, and regulating gut microbiota and metabolite production.
A Tapered Cuff Tracheal Tube Decreases the Need for Cuff Pressure Adjustment After Surgical Retraction During Anterior Cervical Spine Surgery: A Randomized Controlled, Double-Blind Trial
Authors: Li Yi-Shiuan , Tan Elise Chia-Hui , Tsai Yueh-Ju , Mandell Mercedes Susan , Huang Shiang-Suo , Chiang Ting-Yun , Huang Wen-Cheng , Chang Wen-Kuei , Chu Ya-Chun 
Published: June 2022

BackgroundSurgical retraction to expose the vertebrae during anterior cervical spine surgery increases tracheal tube cuff pressure and may worsen postoperative sore throat and dysphonia. This randomized double-blind study investigated the effect of cuff shape on intraoperative cuff pressure and postoperative sore throat and dysphonia.MethodsEighty patients were randomized to tracheal intubation with a tapered cuff or a conventional cylindrical high-volume low-pressure cuff (control) during anesthesia. Intraoperative cuff pressures were compared. The primary outcome was the incidence of pressure adjustment needed when the cuff pressure increased to &gt; 25 mm Hg after surgical retraction. The secondary outcome was the incidence of postoperative sore throat and dysphonia.ResultsThe incidence of pressure adjustment after surgical retraction was significantly lower in the tapered group than in the control group (13% vs. 48%; P = 0.001; relative risk reduction, 74%). The median [interquartile range (IQR)] cuff pressure (mm Hg) was significantly lower for the tapered cuff than for the control cuff before surgical retraction [9 (7–12) vs. 12 (10–15); P &lt; 0.001] and after retraction [18 (15–23) vs. 25 (18–31); P = 0.007]. The median (IQR) postoperative dysphonia score assessed by a single speech-language pathologist was lower in the tapered group than in the control group [4 (3–6) vs. 5.5 (5–7); P = 0.008].ConclusionA tapered cuff tracheal tube decreased the need for the adjustment of cuff pressure after surgical retraction during anterior cervical spine surgery, thereby avoiding intraoperative pressure increase. It also has a better outcome in terms of dysphonia.Clinical Trial Registration[www.clinicaltrials.gov], identifier [NCT04591769].
Breast Cancer Subtypes Based on Hypoxia-Related Gene Sets Identify Potential Therapeutic Agents
Authors: Xiong Zhenchong , Huang Weiling , Zhong Wenjing , Fu Jianchang , Feng Jikun , Wang Xi , Ling Feihai 
Published: June 2022

Purpose: The hypoxic tumor microenvironment was reported to be involved in different tumorigenesis mechanisms of breast cancer (BC). We aimed to establish a hypoxia-related gene signature to identify a new BC subtype through the clustering analysis and explore potential compounds targeting the BC subtypes.Methods: Gene expression data and clinical features of BC and adjacent non-tumor tissues were downloaded from the Cancer Genome Atlas-Breast cancer (TCGA-BRCA) database. We comprehensively revealed the activity changes of Gene Ontology (GO) biological processes (BP) gene sets in BC by gene set variation analysis (GSVA) and identified three hypoxia-related BC subtypes. We then matched the differentially expressed gene profile of each subtype with the gene profile in CMap database to identify the potential agents targeting the BC subtypes.Results: 562 of Gene Ontology biological processes gene sets significantly correlated with hypoxia score in breast cancer. 969 BC patients were clustered into three subtypes based on the enrichment score of hypoxia-associated gene sets. Subtype 1 patients displayed better survival than subtype 2 and 3. KEGG pathway enrichment analysis of each subtype was performed based on the unique differential expression genes profile. In subtype 1, the upregulated genes were associated with lipid and amino acid metabolism regulation; in subtype 2, the upregulated genes were associated with metabolic energy regulation, while in subtype 3, the upregulated genes were associated with apoptosis and protein process. Using the CMap database, 55, 111 and 63 compounds were identified, targeting subtype 1, 2, and 3, respectively.Conclusion: In this study, novel hypoxia-related subtypes were developed for patients with BC. In addition, biological processes associated with differential expression genes profile and potential therapeutic target compounds were identified in each subtype. The new classification might provide a better understanding of the role of hypoxia in breast cancer and more individualized treatment for patients.
A Metabolic Gene Signature to Predict Breast Cancer Prognosis
Authors: Lu Jun , Liu Pinbo , Zhang Ran 
Published: June 2022

Background: The existing metabolic gene signatures for predicting breast cancer outcomes only focus on gene expression data without considering clinical characteristics. Therefore, this study aimed to establish a predictive risk model combining metabolic enzyme genes and clinicopathological characteristics to predict the overall survival in patients with breast cancer.Methods: Transcriptomics and corresponding clinical data for patients with breast cancer were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Differentially expressed metabolic genes between tumors and normal tissues were identified in the TCGA dataset (training dataset). A prognostic model was then built using univariate and multifactorial Cox proportional hazards regression analyses in the training dataset. The capability of the predictive model was then assessed using the receiver operating characteristic in both datasets. Pathway enrichment analysis and immune cell infiltration were performed using Kyoto Encyclopedia of Genes and Genomes (KEGG)/Gene Ontology (GO) enrichment and CIBERSORT algorithm, respectively.Results: In breast cancer and normal tissues, 212 metabolic enzyme genes were differentially expressed. The predictive model included four factors: age, stage, and expression of SLC35A2 and PLA2G10. Patients with breast cancer were classified into high- and low-risk groups based on the model; the high-risk group had a significantly poorer overall survival rate than the low-risk group. Furthermore, the two risk groups showed different activation of pathways and alterations in the properties of tumor microenvironment-infiltrating immune cells.Conclusion: We developed a powerful model to predict prognosis in patients with breast cancer by combining the gene expression of metabolic enzymes with clinicopathological characteristics.
Excessive Visit-to-Visit Small and Dense Low-Density Lipoproteins Elevate Cerebral Small Vessel Disease Progression Risk in the Elderly
Authors: Liu Weike , Xu Jing , Song Huajing , Zhang Chunju , Yao Yanli , Zhang Hua , Li Yue-Chun , Liu Zhendong 
Published: June 2022

ObjectiveSmall and dense low-density lipoprotein (sdLDL) elevation may be among the most sensitive early biomarkers for nascent cardiovascular disease. This study, therefore, investigated the association between visit-to-visit changes in sdLDL and cerebral small vessel disease (CSVD) progression in older individuals, and the influence of Apolipoprotein E (APOE) genotype on this association.MethodsBetween April 2007 and July 2009, 1,143 participants ≥60 years old were recruited from the Shandong region of China, and sdLDL was measured at baseline and at each follow-up visit. White matter hyperintensities (WMHs), lacunes, microbleeds, and enlarged perivascular spaces (EPVSs) were assessed by magnetic resonance imaging. The APOE genotype was determined and participants were stratified as ε4-positive or ε4-negative.ResultsDuring an average follow-up of 86.0 months, 225 participants (19.7%) developed WMH progression, 193 (16.9%) lacune progression, 170 (14.9%) microbleed progression, and 185 (16.2%) EPVS progression. Compared with patients in the first (lowest) tertile of visit-to-visit mean sdLDL, those in the second and third tertiles demonstrated significantly greater risks of WMH progression (53.5 and 105.3% higher), lacune progression (53.3 and 60.8%), microbleed progression (47.2 and 127.6%), and EPVS progression (54.0 and 135.0%) after adjustment for confounders (all adjusted P values for trends &lt;0.001). Compared with patients in the first tertile of visit-to-visit sdLDL SD, those in the second and third tertiles also demonstrated significantly greater risks of WMH progression (49.9% and 143.6%), lacune progression (75.3 and 178.0%), microbleed progression (12.7 and 64.7%), and EPVS progression (41.7 and 114.6%) after adjustment (all P &lt; 0.001). There were significant and positive visit-to-visit mean sdLDL × visit-to-visit sdLDL SD, visit-to-visit mean sdLD×ε4-positive, visit-to-visit sdLDL SD×ε4-positive, and visit-to-visit mean sdLDL×visit-to-visit sdLDL SD×ε4-positive interactions influencing CSVD progression after confounder adjustment (all P &lt; 0.05).ConclusionLarge and variable visit-to-visit changes in sdLDL are independent predictors of aggressive CSVD progression, and this association is strongly influenced by APOE ε4 allele genotype.