bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do not judge a business idea by its cover: The relation between topics in business ideas and incorporation probability
Authors: Birkholz Jessica 
Published: September 2022

AbstractIt is of key importance to identify the degree of novelty and probability of incorporation of business ideas in an early stage, so that targeted support of these different types of entrepreneurship is possible. Selection of business ideas for investments and support programs rely on quantitative and qualitative metrics. The qualitative assessment, however, is biased by subjective impressions and experiences of the decision-maker. Therefore, this paper examines the narrative of business idea descriptions to improve the identification of the degree of novelty and to enhance the estimation of the incorporation probability by advancing the objectivity of qualitative metrics. The paper aims to answer two questions: (1) Are there differences in topic prevalences in novel and non-novel business ideas?, and (2) Does the composition of topics related to a business idea influence its incorporation probability? Structural topic modelling and classification tree analysis are applied on business idea descriptions from a competition in Bremen, Germany, from 2003 until 2019. The results show that business idea descriptions are a rich source of information to identify novel and non-novel business ideas with higher incorporation prospects.
Williamson on conditionals and testimony
Authors: Krzyżanowska Karolina , Douven Igor 
Published: September 2022

AbstractIn Suppose and Tell, Williamson makes a new case for the material conditional account. He tries to explain away apparently countervailing data by arguing that these have been misinterpreted because researchers have overlooked the role of heuristics in the processing of conditionals. Cases involving the receipt of apparently conflicting conditionals play an important dialectical role in Williamson’s book: they are supposed to provide evidence for the material conditional account as well as for the defeasibility of a key procedure underlying our everyday assessments of conditionals. We argue that they can serve neither of these purposes and that Williamson overestimates the reach of heuristics. We specifically challenge Williamson’s assumption that, in the kind of cases centrally at issue in his book, the recipient of conflicting conditionals will typically accept those at face value, even granting Williamson that conditionals can be freely passed among speakers under normal conditions of testimony.
Methodik und Interpretation vergleichender Krankenkassendatenstudien: methodische Grundlagen (Teil 1)
Authors: Wilke Thomas , Mueller Sabrina , Ghiani Marco , Maywald Ulf 
Published: September 2022

Zusammenfassung
Hintergrund
Vergleichende Krankenkassendatenstudien können wichtige Evidenz zur Bewertung der Wirksamkeit und Sicherheit von Therapien in der Versorgungspraxis generieren. Ihre Interpretation ist jedoch angesichts methodischer Unsicherheiten herausfordernd.

Ziel der Arbeit
Ziel dieses Beitrags ist es, wesentliche methodische Elemente einer vergleichenden Krankenkassendatenstudie darzustellen und – in einem speziellen zweiten Beitrag – deren Einfluss exemplarisch an einem Beispiel zu erläutern.

Material und Methoden
Methodische Optionen für vergleichende Krankenkassendatenstudien wurden auf Basis einer Analyse existierender Guidelines zu Versorgungsforschungs- und Routinedatenanalysen abgeleitet und systematisiert.

Ergebnisse
Insgesamt 7 methodische Dimensionen, die den Charakter einer vergleichenden Krankenkassendatenstudie bestimmen, wurden identifiziert: (1) grundlegendes Studiendesign, (2) Identifikation der Studienpopulation und der Vergleichsgruppe, (3) Bestimmung Indexdatum, (4) Definition Beobachtungsperiode inklusive Censoring, (5) Adjustierung Baseline-Charakteristika, (6) Auswahl interessierender Outcomes sowie (7) Definition Maßzahlen des Vergleichs und deren Analyse.

Schlussfolgerungen
Publikationen zu vergleichenden Krankenkassendatenstudien sollten transparent die getroffenen Annahmen darstellen und begründen, warum entsprechende Entscheidungen in den relevanten 7 Dimensionen getroffen wurden.
Non-glomerular Tip Lesion Focal Segmental Glomerulosclerosis as a Negative Predictor in Idiopathic Membranous Nephropathy
Authors: Wang Hui , Wan Cheng , Jiang Man , Zhang Chun 
Published: September 2022

Abstract
Objective
To assess the significance of focal segmental glomerulosclerosis (FSGS) variants on clinicopathological characteristics and short-term outcomes in idiopathic membranous nephropathy (IMN) patients.

Methods
The clinicopathological data of 146 IMN patients diagnosed between December 2016 and March 2019 in our center were collected and analyzed. These patients were divided into the pure IMN group, IMN with glomerular tip lesion (GTL) group, and IMN with non-GTL FSGS group.

Results
The IMN with non-GTL FSGS and IMN with GTL groups both had higher proportions of patients with hypertension, lower serum albumin, and severe proteinuria, while the IMN with non-GTL FSGS group additionally showed higher blood pressure and serum cholesterol, and lower serum IgG than the IMN group (all P<0.05). As for pathology, the IMN with non-GTL FSGS group had higher proportions of patients with acute tubular injury and moderate to severe chronic injuries than the IMN group (all P<0.05). In the IMN, IMN with GTL, and IMN with non-GTL FSGS groups, the overall one-year remission rates were 81.6%, 76%, and 58.8%, respectively. Furthermore, the IMN with non-GTL FSGS group showed the lowest cumulative incidence to reach remission within one year. Multivariate Cox logistic analysis demonstrated that higher level of serum anti-M-type phospholipase A2 receptor antibody and the existence of non-GTL FSGS lesion were independent predictors for no remission in IMN patients.

Conclusion
The non-GTL FSGS lesion was a novel negative predictor in IMN and should be taken into account in the management of IMN.
Videospiele und Schlaf – negativer Zusammenhang oder unbedenkliches Zocken?
Authors: Tholl Chuck , Soffner Markus , Bickmann Peter , Alesi André , Froböse Ingo 
Published: September 2022

Zusammenfassung
Hintergrund
Das Spielen von Videospielen vor dem Schlafengehen kann einen Einfluss auf die Qualität und Quantität des Schlafs haben.

Fragestellung
Es gilt herauszufinden, welche Faktoren dabei beeinflusst werden und wie diese messbar gemacht werden können.

Material und Methode
Um eine Übersicht zu geben und Handlungsempfehlungen auszusprechen, wurden aktuelle Studien analysiert und gegenübergestellt.

Ergebnisse
Das Spielen von Videospielen vor dem Schlafengehen kann speziell bei Kindern und Jugendlichen zu einer erhöhten Einschlafdauer und insgesamt einer erhöhten Müdigkeit führen. Die Bildschirmhelligkeit (Exposition von blauem Licht) und die Aktivierung des Sympathikus durch das Spielen sind dabei relevante Faktoren. Vor allem actionreiche Videospiele führen zu einer größeren Aktivierung als vergleichbare ruhigere Aktivitäten.

Schlussfolgerung
Zusammenfassend kann gesagt werden, dass der Schlaf grundsätzlich durch das Videospielen negativ beeinflusst werden kann. Eine verlängerte Einschlafdauer und verringerte Tiefschlafphasen können als Folge vom abendlichen Videospielkonsum auftreten. Hierbei scheint die Sympathikotonie eine dominantere Rolle als die Exposition von blauem Licht zu spielen. Kinder, Jugendliche und professionelle Videospielende sind potenzielle Risikogruppen und müssen demnach über ein verantwortungsvolles Videospielverhalten aufgeklärt werden. Zur Quantifizierung der Aktivierung können verschiedene Messparameter dienen. Insbesondere die Herzratenvariabilität stellt einen praktikablen Parameter dar.
Myeloid But Not Endothelial Expression of the CB2 Receptor Promotes Atherogenesis in the Context of Elevated Levels of the Endocannabinoid 2-Arachidonoylglycerol
Authors: Avraamidou Elina , Nöthel Moritz , Danisch Melina , Bindila Laura , Schmidt Susanne V. , Lutz Beat , Nickenig Georg , Jehle Julian 
Published: September 2022

AbstractThe endocannabinoid 2-arachidonoylglycerol (2-AG) is an inflammatory mediator and ligand for the cannabinoid receptors CB1 and CB2. We investigated the atherogenic mechanisms set in motion by 2-AG. Therefore, we created two atherosclerotic mouse models with distinct cell-specific knockouts of the CB2 receptor on either myeloid or endothelial cells. These mice were treated with JZL184, resulting in elevated plasma levels of 2-AG. After a high-fat high-cholesterol diet, atherosclerotic plaques were analyzed. The atherogenic effect of 2-AG was abrogated in mice lacking myeloid expression of the CB2 receptor but not in mice lacking endothelial expression of the CB2 receptor. In vitro, treatment of human monocytes with 2-AG led to the increased production of reactive oxygen species (ROS) and IL-1β. In conclusion, 2-AG shows an atherogenic effect in vivo, dependent on the presence of the CB2 receptor on myeloid cells. In addition, our in vitro data revealed 2-AG to promote inflammatory signalling in monocytes.
Graphical abstract
2-Arachidonoylglycerol shows an atherogenic effect that is abrogated in mice lacking myeloid expression of the CB2 receptor.
A case of fulminant respiratory diphtheria in a 24-year-old Afghan refugee in Austria in May 2022: a case report
Authors: Traugott M. T. , Pleininger S. , Inschlag-Tisch S. , Eder B. , Seitz T. , Merrelaar A. , Reiß-Kornfehl J. , Fussi J. , Schindler S. , Blaschitz M. , Heger F. , Indra A. , Karolyi M. , Staudacher M. , Oelschlaegel T. , Hoepler W. , Neuhold S. , Wenisch C. 
Published: September 2022

Abstract
Purpose
Raising awareness of respiratory diphtheria and for the importance of early antitoxin administration.

Methods
Report of a case of fulminant, imported respiratory diphtheria in an otherwise healthy 24-year-old Afghan refugee in Austria in May 2022.

Result
This was the first case of respiratory diphtheria in Austria since 1993. Diphtheria antitoxin was administered at an already progressed disease stage. This delay contributed to a fulminant disease course with multiorgan failure and death.

Conclusion
In high-income countries with low case numbers, awareness of respiratory diphtheria and for the importance of early antitoxin administration must be raised.
CARE: coherent actionable recourse based on sound counterfactual explanations
Authors: Rasouli Peyman , Chieh Yu Ingrid 
Published: September 2022

AbstractCounterfactual explanation (CE) is a popular post hoc interpretability approach that explains how to obtain an alternative outcome from a machine learning model by specifying minimum changes in the input. In line with this context, when the model’s inputs represent actual individuals, actionable recourse (AR) refers to a personalized CE that prescribes feasible changes according to an individual’s preferences. Hence, the quality of ARs highly depends on the soundness of underlying CEs and the proper incorporation of user preferences. To generate sound CEs, several data-level properties, such as proximity and connectedness, should be taken into account. Meanwhile, personalizing explanations demands fulfilling important user-level requirements, like coherency and actionability. The main obstacles to inclusive consideration of the stated properties are their associated modeling and computational complexity as well as the lack of a systematic approach for making a rigorous trade-off between them based on their importance. This paper introduces CARE, an explanation framework that addresses these challenges by formulating the properties as intuitive and computationally efficient objective functions, organized in a modular hierarchy and optimized using a multi-objective optimization algorithm. The devised modular hierarchy enables the arbitration and aggregation of various properties as well as the generation of CEs and AR by choice. CARE involves individuals through a flexible language for defining preferences, facilitates their choice by recommending multiple ARs, and guides their action steps toward their desired outcome. CARE is a model-agnostic approach for explaining any multi-class classification and regression model in mixed-feature tabular settings. We demonstrate the efficacy of our framework through several validation and benchmark experiments on standard data sets and black box models.
Organochlorine pesticides and polychlorinated biphenyls in carnivorous waterbird and fish species from Lake Hawassa, Ethiopia
Authors: Ayele Shiferaw , Mamo Yosef , Deribe Ermias , Eklo Ole Martin 
Published: September 2022

Abstract
Abstract
Agricultural, vector-control and industrial activities around Lake Hawassa pose a risk of organochlorine contamination of the lake biota. To assess organochlorine contamination, we measured levels of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in 3 species of carnivorous waterbird and 3 species of fish. A total of 50 samples of fish and bird species sampled from Lake Hawassa in 2019. We investigated factors influencing accumulation of OCPs and PCBs. Reproductive risk associated with tissue levels of 4,4’-dichloro-diphenyl-dichloro-ethylene (p,p’-DDE) is also estimated. Results show that dichloro-diphenyl-trichloroethane (DDT) is the dominant contaminant found in both bird and fish species. p,p’-DDE is the dominant DDT metabolite in both bird and fish species. Geometric mean of p,p’-DDE varied from 49.8–375.3 and 2.2–7.7 ng g−1 ww in birds and fish, respectively. Average p,p’-DDE level in birds is 33.3 times higher than in fish. p,p’-DDE constitutes 93.4–95.2% of total DDTs in bird species. Degree of exposure, chemical stability, and resistance to environmental and biological degradation could explain higher levels of p,p’-DDE both in bird and fish species. There is significant variation in p,p’-DDE levels among bird and fish species owing to differences in feeding habits, foraging habitat, and lipid content. An increase in DDT levels with increasing size is observed in both bird and fish species. A significant positive association between log-transformed p,p’-DDE, and stable nitrogen isotope ratio (δ15N) values is found. There is no reproductive health risk in bird species as a result of the current levels of p,p’-DDE.

Article Highlights

DDT is the dominant contaminant found in both bird and fish species

There is interspecies variation in accumulation of p,p’-DDE among fish and bird species

p,p’-DDE is biomagnified through food chain involving both bird and fish species
Ultrafast transient absorption and solvation of a super-photoacid in acetoneous environments
Authors: Knorr Johannes , Sülzner Niklas , Geissler Bastian , Spies Christian , Grandjean Alexander , Kutta Roger Jan , Jung Gregor , Nuernberger Patrick 
Published: September 2022

AbstractThe phenomenon of photoacidity, i.e., an increase in acidity by several orders of magnitude upon electronic excitation, is frequently encountered in aromatic alcohols capable of transferring a proton to a suitable acceptor. A promising new class of neutral super-photoacids based on pyranine derivatives has been shown to exhibit pronounced solvatochromic effects. To disclose the underlying mechanisms contributing to excited-state proton transfer (ESPT) and the temporal characteristics of solvation and ESPT, we scrutinize the associated ultrafast dynamics of the strongest photoacid of this class, namely tris(1,1,1,3,3,3-hexafluoropropan-2-yl)8-hydroxypyrene-1,3,6-trisulfonate, in acetoneous environment, thereby finding experimental evidence for ESPT even under these adverse conditions for proton transfer. Juxtaposing results from time-correlated single-photon counting and femtosecond transient absorption measurements combined with a complete decomposition of all signal components, i.e., absorption of ground and excited states as well as stimulated emission, we disclose dynamics of solvation, rotational diffusion, and radiative relaxation processes in acetone and identify the relevant steps of ESPT along with the associated time scales.Graphical abstract
Photochemical defense as trait of fungi from Cortinarius subgenus Dermocybe
Authors: Hannecker Anna , Huymann Lesley , Hammerle Fabian , Peintner Ursula , Siewert Bianka 
Published: September 2022

AbstractThe photobiological activity of ten colorful species belonging to subgenus Dermocybe of the basidiomycete genus Cortinarius was investigated. Extracts of all species produced singlet oxygen and are thus photoactive. Pigment analysis was performed and showed similarities of the anthraquinone pigments across the species in dependency to their respective pigmentation types. Detailed content analysis of the pigments in the whole agaricoid fruiting body compared to the three different tissue types (pileus, stipe, and lamellae) revealed that the pigments emodin, dermocybin, and dermorubin, as well as their respective glycosides, are enhanced in the gills. In an independent experiment, the gills were shown to be the most photoactive tissues of the fruiting body. Photobiological experiments with invertebrates (i.e., glassworm Chaoborus crystallinus) proved a phototoxic effect of the methanolic extract of the red blood webcap (Cortinarius sanguineus var. aurantiovaginatus). This work adds further evidence to a common photobiological trait in Cortinarius subgenus Dermocybe and underpins the possibility of a photochemical defense mechanism in fungi.
Graphical abstract
Performance and design analyses of various configurations of dew point evaporative cooling-based desiccant air-conditioning (DAC) systems for hot and humid conditions
Authors: Lao Marco , Lin Jie , Mikšík František , Thu Kyaw , Miyazaki Takahiko 
Published: September 2022

AbstractThermally driven desiccant- and evaporative cooling-based technologies are promising greener and cheaper alternatives to compressor-based systems due to the separate handling of latent and sensible loads. Desiccant air-conditioning (DAC) systems comprise a desiccant dehumidifier, a sensible cooling unit, a heat source for regeneration, and a heat recovery unit. These components of a DAC system can be arranged in various ways to give different configurations with varying advantages and disadvantages. In this study, five configurations of thermally driven desiccant dehumidifier- and dew point evaporative cooling (DPEC)-based DAC systems were investigated. Seven evaluation criteria namely regeneration temperature, desiccant moisture removal capacity, COPt, DPEC L/H, heat exchanger UA, system size, and fan power requirement were employed. Results show that the standard cycle in ventilation mode offers the highest COPt despite having the highest regeneration temperature. Recirculation of the return room air can operate at a significantly lower regeneration temperature at the expense of larger equipment size and much lower COPt. DAC with an internally cooled dehumidification can operate at low regeneration temperature at the expense of higher fan power and slightly lower COPt. Dividing the dehumidification process into two stages can offer operation at moderately lower regeneration temperature without severely affecting the other criteria. This study can serve as a guide for the selection of an appropriate DAC configuration for space cooling depending on the objective criteria and the resources available.
Outcomes of blood and marrow transplantation in children less than 2-years of age
Authors: Khan Saadiya , Siddiqui Khawar , ElSolh Hasan , AlJefri Abdullah , AlAhmari Ali , Ghemlas Ibrahim , AlSaedi Hawazen , AlEnazi Awatif , AlSeraihi Amal , Ayas Mouhab 
Published: September 2022

Objectives:
Allogeneic hematopoietic cell transplantation (Allo-HCT) is a curative option for children with various malignant and non-malignant diseases. Most reports studied all age groups amongst children. Herein we analyzed our data in children transplanted at or less than 2-years of age.

Patients and methods:
We reviewed medical charts of 618 patients who underwent 666 transplantation at our center between 1993 and 2015. There were 340 boys and 278 girls. Median age was 0.7 years (range 0.04—2). Stem cell source was bone marrow (BM) in 492 (73.9%), unrelated umbilical cord blood (UCB) in 161 (24.2%) followed by peripheral blood stem cell (PBSC) in 13 (2%) patients. Matched siblings were the most common donors (n = 356, 53.5%), followed by unrelated (n = 161, 24.2%) with hap- loidentical family member donors in 29 (4.4%) transplants. Disease groups were categorized as benign hematology (Thalassemia, Fanconi, Aplastic anemia etc.), benign neoplasm (Langerhans cell histiocytosis, Hemophagocytic Lymphohistiocytosis etc.), non-neoplasms (metabolic disorders, immunodeficiency disorders etc.) and Leukemia/lymphomas (myeloid and lymphoid malignancies etc.)

Results:
Cumulative incidence of acute GvHD (I-IV) was 31.5% (n = 210) and grade III-IV GvHD was 8.7% (n = 58). At median follow-up of 115.1 months, the cumulative probability of overall survival (OS) at 5 years was 70.0% ± 1.9%. Our mortality rate was 31.2% (n = 193). The five-year OS was significantly better in patients transplanted for benign hematological disorders (P = .001). Patients transplanted using BM/ PBSC as source of stem cells fared significantly better compared to those in which CB was used (P<.001). Post-transplant graft failure remains the leading cause requiring further transplants in this age group. In conclusion, the cumulative probability of OS at 5 years was about 70.0% for all with an OS of 61% in our haploidentical recipients.

Conclusion:
Analyzing our institutional data over time has enabled us to develop tentative strategies to minimize transplant related toxicities in very young children who are candidates for allo-HCT.
Molecular concordance of methicillin-resistant Staphylococcus aureus isolates from healthcare workers and patients
Authors: Adediran Timileyin Y. , Hitchcock Stephanie , Johnson J. Kristie , Stine O. Colin , Leekha Surbhi , Thom Kerri A. , Liang Yuanyuan , Rasko David A. , Harris Anthony D. 
Published: September 2022

AbstractBackground:Methicillin-resistant Staphylococcus aureus (MRSA) is a significant nosocomial pathogen in the ICU. MRSA contamination of healthcare personnel (HCP) gloves and gowns after providing care to patients with MRSA occurs at a rate of 14%–16% in the ICU setting. Little is known about whether the MRSA isolates identified on HCP gown and gloves following patient care activities are the same as MRSA isolates identified as colonizing or infecting the patient.Methods:From a multisite cohort of 388 independent patient MRSA isolates and their corresponding HCP gown and glove isolates, we selected 91 isolates pairs using a probability to proportion size (PPS) sampling method. To determine whether the patient and HCP gown or gloves isolates were genetically similar, we used 5 comparative genomic typing methods: phylogenetic analysis, spa typing, multilocus sequence typing (MLST), large-scale BLAST score ratio (LSBSR), and single-nucleotide variant (SNV) analysis.Results:We identified that 56 (61.5%) of isolate pairs were genetically similar at least by 4 of the methods. Comparably, the spa typing and the LSBSR analyses revealed that >75% of the examined isolate pairs were concordant, with the thresholds established for each analysis.Conclusions:Many of the patient MRSA isolates were genetically similar to those on the HCP gown or gloves following a patient care activity. This finding indicates that the patient is often the primary source of the MRSA isolates transmitted to the HCP, which can potentially be spread to other patients or hospital settings through HCP vectors. These results have important implications because they provide additional evidence for hospitals considering ending the use of contact precautions (gloves and gowns) for MRSA patients.