bluuebunny/crossref_metadata_2025_split huggingface dataset:
Media Promosi Desain Booklet Company Profile Pada PT. Komara Putra Manggala
Authors: Cahyadi Dede , Maulana Ade Rifki , Ginting Dicky Ardian 
Published: February 2022

Submission of information and promotions in a company can be done through various media, one of which is print media in the form of booklets. The effectiveness of booklet print media is still being used in several companies, agencies, schools, and other business entities. Promotional media used previously at PT. Komara Putra Manggala is not considered optimal. So we need a media campaign that can be more effective and efficient. Booklet is the right medium for conveying information to this company because booklet promotional media can cover almost all information and promotions offered by the company. With the arrangement of layouts and images that are arranged so that they can convey the contents of the promotion. The method in this research, namely, data collection through observation, interviews, and literature study, then analysis of media design and design concepts. Booklet Company Profile Design PT. Komara Putra Manggala contains company history, services offered, choice of fleet class, and company contacts designed using : Adobe Illustrator CS6 and Adobe Photoshop CS6. Through the Company Profile Booklet PT. Komara Putra Manggala is expected to attract the interest of the audience to use the services of the company.
Keywords—Booklet; Promotion; Information; Media

Penyampaian informasi dan promosi pada suatu perusahaan dapat dilakukan melalui berbagai media, salah satunya media cetak berupa booklet. Keefektifan media cetak booklet hingga saat ini masih digunakan di beberapa perusahaan, instansi, sekolah, dan badan usaha lainnya. Media promosi yang digunakan sebelumnya pada PT. Komara Putra Manggala dirasa belum optimal. Sehingga diperlukan adanya media promosi yang dapat lebih efektif dan juga efisien. Booklet adalah media yang tepat untuk penyampaian informasi pada perusahaan ini dikarenakan media promosi booklet dapat mencakup hampir seluruh informasi dan promosi yang ditawarkan perusahaan. Dengan tatanan layout dan image yang disusun sehingga dapat menyampaikan isi dari promosi tersebut. Metode pada penelitian ini yaitu, mencari data melalui observasi, tanya jawab, dan studi literature, lalu analisa perancangan media dan konsep desain. Desain Booklet Company Profile PT. Komara Putra Manggala berisi tentang sejarah perusahaan, jasa yang ditawarkan, pilihan kelas armada, dan juga kontak perusahaan yang dirancang menggunakan: Adobe Illustrator CS6 dan Adobe Photoshop CS6. Melalui Booklet Company Profile PT. Komara Putra Manggala diharapkan dapat menarik minat audience untuk menggunakan jasa dari perusahaan tersebut.
Kata Kunci—Booklet; Promosi; Informasi; Media.
Redesign Corporate Identity Guna Peningkatan Image Perusahaan Pada PT Yugi Indonesia
Authors: Desrianti Dewi Immaniar , Santoso Sugeng , Adiputra Febri 
Published: February 2022

In the increasingly rapid development of the business world, a corporate identity is needed that can represent the character of a company's business, product, or service. Corporate identity represented by the logo is an identity as a differentiator between each company. However, problems arise with the development of the times, the company realizes that the logo as a corporate identity that is made as a reflection of the vision and mission as well as the culture of a company becomes obsolete. From this condition, the step to redesign the corporate identity logo is considered to be a wise choice so that the logo as a corporate identity can communicate precisely with what is represented by the company. The purpose of this research discussion is the creation of a GSM book (Graphic Standard Manual) as a reference for designing a logo design which is a corporate identity that can be arranged systematically so that there are no more mistakes in its implementation to any visual media used by the company. In the study using a problem analysis method, data collection, design and media design concepts including rough layout, comprehensive layout, and final artwork, redesigning the logo design using Adobe Illustrator CC18 software. From designing the logo as a corporate identity, it is hoped that it can strengthen the existence of PT Yugi Indonesia in the community.
Keywords—Corporate Identity; Redesign; Logo

Dalam perkembangan dunia usaha yang kian pesat dibutuhkan corporate identity yang dapat mewakili karakter dari usaha, produk, atau jasa dari sebuah perusahaan. Corporate identity yang diwakili oleh logo merupakan identitas sebagai pembeda antara setiap perusahaan. Namun permasalahan timbul seiring berkembangnya zaman, perusahaan menyadari jika logo sebagai identitas perusahaan yang dibuat sebagai cerminan dari visi dan misi juga budaya pada sebuah perusahaan menjadi usang. Dari kondisi tersebut langkah untuk melakukan redesain logo identitas perusahaan dinilai menjadi pilihan yang bijak supaya logo sebagai identitas perusahaan bisa berkomunikasi secara tepat dengan apa yang diwakili oleh perusahaan. Tujuan pembahasan penelitian ini adalah terciptanya buku GSM (Grafik Standar Manual) sebagai acuan dari perancangan desain logo yang merupakan sebuah corporate identity bisa terangkai secara sitematis supaya tidak terjadi lagi kesalahan dalam pengimplementasiannya kepada setiap media visual yang digunakan perusahaan. Dalam penelitian menggunakan sebuah metode analisa permasalahan, pengumpulan data, perancangan dan konsep media desain meliputi layout kasar, layout komprehensif, serta final artwork, perancangan ulang desain logo menggunakan software adobe illustrator CC18. Dari perancangan logo sebagai corporite identity diharapkan dapat memperkuat eksistensi PT Yugi Indonesia di masyarakat.
Kata Kunci—Corporate Identity; Redesign; Logo
Apuntes sobre participación e innovación en Servicios sociales. Una aproximación cualitativa.
Authors: Palacín Bartrolí Càndid , Muñoz García Araceli , Magaña González Claudia Rocio , Boixadós Porquet Adela 
Published: February 2022

<p><em>Objetivo</em>: El artículo tiene dos objetivos: a.) identificar la importancia de la participación de las familias en los marcos organizacionales de los servicios sociales de atención básica; y, b.) explorar la innovación y la participación en el proceso y en los modelos de intervención a través de tres ejes: los dispositivos de atención y la centralidad de los servicios sociales como punto de referencia en el territorio; la participación de la innovación en la intervención de los servicios sociales de atención básica; y la relación entre familias y profesionales en estos servicios.</p><p><em>Metodología</em>: Es una investigación cualitativa en la que se llevaron a cabo 38 entrevistas individuales y 9 grupos de discusión. En total participaron 125 personas, de las cuales 42 fueron familias acompañadas por los servicios sociales de atención básica, 55 profesionales y 28 cargos de gestión.</p><p><em>Resultados</em>: Los principales hallazgos se centran en las propuestas de cambio en los marcos organizacionales, particularmente en los espacios existentes y en las políticas de comunicación desarrolladas. El énfasis de los agentes en resignificar los espacios y la incidencia en políticas de comunicación orienta hacía nuevas interrogantes centradas en el papel del trabajo social, sobre todo de corte grupal y comunitario.</p><p> </p><p><em>Conclusiones</em>: A partir de los resultados se delinean algunos caminos de cómo pensar la innovación y propuestas, más allá de la perspectiva hegemónica de la innovación de sustitución o inclusión de “tecnologías de intervención”. En el proceso de intervención y en la relación profesional, es imprescindible pensar y diseñar nuevas estrategias de colaboración entre personas, familias y profesionales con el fin de lograr un acercamiento mutuo y un progreso conjunto. Sin embargo, surgen cuestionamientos abiertos alrededor de que algunas innovaciones propuestas forman parte del marco teórico del trabajo social.</p>
Engineered Human Meniscus in Modeling Sex Differences of Knee Osteoarthritis in Vitro
Authors: Ma Zhiyao , Li David Xinzheyang , Kunze Melanie , Mulet-Sierra Aillette , Westover Lindsey , Adesida Adetola B. 
Published: February 2022

Background: Osteoarthritis (OA) primarily affects mechanical load-bearing joints. The knee joint is the most impacted by OA. Knee OA (KOA) occurs in almost all demographic groups, but the prevalence and severity are disproportionately higher in females. The molecular mechanism underlying the pathogenesis and progression of KOA is unknown. The molecular basis of biological sex matters of KOA is not fully understood. Mechanical stimulation plays a vital role in modulating OA-related responses of load-bearing tissues. Mechanical unloading by simulated microgravity (SMG) induced OA-like gene expression in engineered cartilage, while mechanical loading by cyclic hydrostatic pressure (CHP), on the other hand, exerted a pro-chondrogenic effect. This study aimed to evaluate the effects of mechanical loading and unloading via CHP and SMG, respectively, on the OA-related profile changes of engineered meniscus tissues and explore biological sex-related differences.Methods: Tissue-engineered menisci were made from female and male meniscus fibrochondrocytes (MFCs) under static conditions of normal gravity in chondrogenic media and subjected to SMG and CHP culture. Constructs were assayed via histology, immunofluorescence, GAG/DNA assays, RNA sequencing, and testing of mechanical properties.Results: The mRNA expression of ACAN and COL2A1, was upregulated by CHP but downregulated by SMG. COL10A1, a marker for chondrocyte hypertrophy, was downregulated by CHP compared to SMG. Furthermore, CHP increased GAG/DNA levels and wet weight in both female and male donors, but only significantly in females. From the transcriptomics, CHP and SMG significantly modulated genes related to the ossification, regulation of ossification, extracellular matrix, and angiogenesis Gene Ontology (GO) terms. A clear difference in fold-change magnitude and direction was seen between the two treatments for many of the genes. Furthermore, differences in fold-change magnitudes were seen between male and female donors within each treatment. SMG and CHP also significantly modulated genes in OA-related KEGG pathways, such as mineral absorption, Wnt signalling pathway, and HIF-1 signalling pathway.Conclusion: Engineered menisci responded to CHP and SMG in a sex-dependent manner. SMG may induce an OA-like profile, while CHP promotes chondrogenesis. The combination of SMG and CHP could serve as a model to study the early molecular events of KOA and potential drug-targetable pathways.
Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2
Authors: Chen Yan , Wang Guisheng , Yuan Yilin , Zou Ge , Yang Wencong , Tan Qi , Kang Wenyi , She Zhigang 
Published: February 2022

Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E (1) and F (2), one new chromone fusarimone A (5), two new benzofurans fusarifurans A (9) and B (10), three new isocoumarins fusarimarins A–C (11–13), as well as five known analogues 3, 4, 6–8 and 14 were isolated from mangrove endophytic fungus Fusarium sp. 2ST2. Their structures and absolute configurations were established by spectroscopic analysis, density functional theory-gauge invariant atomic orbital NMR calculation with DP4+ statistical analysis, and electronic circular dichroism calculation. Compounds 1 and 2 showed significant cytotoxicity against human A549 cell lines with IC50 values of 8.7 and 4.3 μM, respectively.
Molecular Structural, Hydrogen Bonding Interactions, and Chemical Reactivity Studies of Ezetimibe-L-Proline Cocrystal Using Spectroscopic and Quantum Chemical Approach
Authors: Prajapati Preeti , Pandey Jaya , Tandon Poonam , Sinha Kirti , Shimpi Manishkumar R. 
Published: February 2022

Ezetimibe (EZT) being an anticholesterol drug is frequently used for the reduction of elevated blood cholesterol levels. With the purpose of improving the physicochemical properties of EZT, in the present study, cocrystals of ezetimibe with L-proline have been studied. Theoretical geometry optimization of EZT-L-proline cocrystal, energies, and structure–activity relationship was carried out at the DFT level of theory using B3LYP functional complemented by 6-311++G(d,p) basis set. To better understand the role of hydrogen bonding, two different models (EZT + L-proline and EZT + 2L-proline) of EZT-L-proline cocrystal were studied. Spectral techniques (FTIR and FT-Raman) combined with quantum chemical methodologies were successfully implemented for the detailed vibrational assignment of fundamental modes. It is a zwitterionic cocrystal hydrogen bonded with the OH group of EZT and the COO−group of L-proline. The existence and strength of hydrogen bonds were examined by a natural bond orbital analysis (NBO) supported by the quantum theory of atoms in molecule (QTAIM). Chemical reactivity was reflected by the HOMO–LUMO analysis. A smaller energy gap in the cocrystal in comparison to API shows that a cocrystal is softer and chemically more reactive. MEPS and Fukui functions revealed the reactive sites of cocrystals. The calculated binding energy of the cocrystal from counterpoise method was −11.44 kcal/mol (EZT + L-proline) and −26.19 kcal/mol (EZT + 2L-proline). The comparative study between EZT-L-proline and EZT suggest that cocrystals can be better used as an alternative to comprehend the effect of hydrogen bonding in biomolecules and enhance the pharmacological properties of active pharmaceutical ingredients (APIs).
Co-Seismic Surface Ruptures of the CE 1738 M 7.6 Dangjiang Earthquake Along the NW Continuation of the Xianshuihe Fault Zone and Tectonic Implications for the Central Tibetan Plateau
Authors: Yu Zhongyuan , Yin Na , Xiao Peng , Chen Baixu 
Published: February 2022

The role of large-scale strike-slip faults in high-elevation areas in absorbing the strain resulting from plate convergence has yet to be scientifically understood. The Dang Jiang Fault (DJF), as the NW continuation of the Xianshuihe Fault Zone (XFZ) in the central Qinghai-Tibetan Plateau, may provide an excellent testing ground for this question, given its high slip rate, sparse vegetative cover, minimal modification, and possible relationship with the CE 1738 Dangjiang destructive earthquake. However, co-seismic surface ruptures and seismotectonics remain in dispute because of inconvenient transportation and lack of oxygen at high altitudes. Thus, field investigations are conducted here to determine co-seismic surface ruptures. The newly synthesized data from geologic observations, historical record reviews, geomorphic mapping, trench logging, and sample dating indicate that the CE 1738 Dangjiang earthquake produced an ∼100 km-long surface rupture that includes offsets of gullies, linear scarps and troughs, sag ponds,en echelonfractures, and pressure ridges. The magnitude is re-estimated asM7.6, with average and maximum strike-slip displacements of ∼2.1 ± 0.1 m and ∼3.5 ± 0.1 m, respectively. The DJF has undergone multiple seismic faulting events, and the linear fitting surface displacement rate in the Holocene is ∼6.3 ± 1.9 mm/yr with a 95% confidence interval. This study implies that the seismic hazard of the DJF cannot be underestimated given that its elapsed time is close to or beyond the recurrence interval of major earthquakes and that the oblique convergence of the Qiangtang Block might be accommodated by the clockwise rotation of the block through repeated left-lateral strike-slip movements along the southern boundary of the Bayan Har Block.
Differential Efficacy of Digital Scaffolding of Numeracy Skills in Kindergartners With Mild Perinatal Aversities
Authors: Merkelbach Inge , Plak Rachel D. , Jong Maria T. Sikkema-de , Rippe Ralph C.A. 
Published: February 2022

Introduction:Children who experienced mild perinatal adversity (i.e., born late preterm or small for gestational age) are at increased risk for delays in early numeracy and literacy, which increases inequality in educational opportunities. However, this group showed increased susceptibility to the characteristics of their educational environment for literacy, especially for those born late preterm. Intervening in this group may thus be particularly beneficial, provided that their educational environment is highly structured. Delays in numeracy and mathematics are most firmly acknowledged in these children. It remains unclear if these children are also more susceptible to their educational numeracy environment. We test the hypothesis of increased susceptibility to characteristics of their educational environment in the field of numeracy.Methods:We tested the efficacy of a digital intervention of two to 3 months, which focused on visual spatial skills in a large randomized controlled trial in a sample of five-to-six-year-old kindergarten pupils from 140 elementary schools. About 45% of all participants showed delays in numeracy, of whom n = 67 (11%) were born late preterm, n = 157 (26%) were born small for gestational age, and n = 389 (63%) had no mild perinatal adversities. Pupils were assigned to a guiding and structured intervention focused on visual spatial skills (n = 294) or a control program (n = 319), targeting literacy skills.Results:The intervention did not show a main effect. The program was not effective in children small for gestational age, but it was for children born late preterm (Cohen’sd= .71, CI = .07–1.36), showing stronger numeracy skills compared to term-born peers in the intervention condition. Early numeracy skills in children born late preterm fell behind compared to term-born peers in the control condition.Conclusion:A highly structured educational numeracy environment, using repetition and adaptive feedback benefited early numeracy skills of late preterm children. These children outperformed their peers in early numeracy skills, while those in the control condition fell behind. Findings align with earlier findings on promoting early literacy in this group through an equivalent literacy intervention. A relatively simple and cost-effective intervention thus may help reduce the risk of educational inequality for children born late pre-term.
Rapid Preparation of Manganese Monoxide by Microwave-Enhanced Selective Carbothermal Reduction
Authors: Chen Jin , He Fei , Gao Lei , Guo Shenghui , Omran Mamdouh , Chen Guo 
Published: February 2022

Most of the manganese resources in China have existed in the form of low-grade pyrolusite which is not utilized efficiently because of the high energy consumption and environmental pollution during the reduction process. Applying microwave heating to minerals reduction endows improved production efficiency and reduced production costs. In the present work, rapid preparation of manganese monoxide (MnO) was attempted through reducing low-grade pyrolusite with coal reducing agent by microwave heating, with the samples characterized by XRD, scanning electron microscopy, XPS as well as TG/DSC. The influences of the reduction reaction parameters on the reduction process of Mn in pyrolusite were comprehensively studied. The results indicated that higher temperatures and longer holding times facilitated the reduction roasting of pyrolusite, and manganese monoxide can be fabricated with a reduction ratio of 97.7% obtained at 650°C for 50 min. The mechanism of the gradual transformation of MnO2 to MnO from the macroscopic to the molecular level was also revealed in the order of MnO2 → Mn2O3 → Mn3O4 → MnO. Compared to traditional roasting, the proposed microwave-enhanced roasting process benefits from the superior kinetic conditions provided by the synergy between microwave enhancement and compact pellets, and thus reduced the roasting temperature and roasting time.
NET Release of Long-Term Surviving Neutrophils
Authors: Kolman Jan Philipp , Pagerols Raluy Laia , Müller Ingo , Nikolaev Viacheslav O. , Trochimiuk Magdalena , Appl Birgit , Wadehn Hannah , Dücker Charlotte Maria , Stoll Fabian David , Boettcher Michael , Reinshagen Konrad , Trah Julian 
Published: February 2022

BackgroundNeutrophil extracellular traps (NETs)—as double-edged swords of innate immunity—are involved in numerous processes such as infection, inflammation and tissue repair. Research on neutrophil granulocytes is limited because of their short lifetime of only a few hours. Several attempts have been made to prolong the half-life of neutrophils using cytokines and bacterial products and have shown promising results. These long-term surviving neutrophils are reported to maintain phagocytic activity and cytokine release; however, little is known regarding their capability to release NETs.MethodsWe analysed the prolongation of neutrophil survival in vitro under various culture conditions using granulocyte colony-stimulating factor (G-CSF), lipopolysaccharide (LPS) or tumour necrosis factor alpha (TNF-α) by flow cytometry and a viability assay. Additionally, we assessed NET formation following stimulation with phorbol 12-myristate 13-acetate (PMA) by immunofluorescence staining, myeloperoxidase (MPO)-DNA sandwich-ELISA and fluorometric assays for cell-free DNA (cfDNA), neutrophil elastase (NE) and myeloperoxidase (MPO).ResultsUntreated neutrophils could form NETs after stimulation with PMA for up to 24 h. Incubation with LPS extended their ability to form NETs for up to 48 h. At 48 h, NET release of neutrophils cultured with LPS was significantly higher compared to that of untreated cells; however, no significantly different enzymatic activity of NE and MPO was observed. Similarly, incubation with G-CSF resulted in significantly higher NET release at 48 h compared to untreated cells. Furthermore, NETs showed significantly higher enzymatic activity of NE and MPO after incubation with G-CSF. Lastly, incubation with TNF-α had no influence on NET release compared to untreated cells although survival counts were altered by TNF-α.ConclusionsG-CSF, LPS or TNF-α each at low concentrations lead to prolonged survival of cultured neutrophils, resulting in considerable differences in NET formation and composition. These results provide new information for the use of neutrophils in long-term experiments for NET formation and provide novel insights for neutrophil behaviour under inflammatory conditions.