bluuebunny/crossref_metadata_2025_split huggingface dataset:
The responsiveness of the Danish version of the Canadian Occupational Performance Measure
Authors: Enemark Larsen Anette , Christensen Jeanette R , Wehberg Sonja 
Published: February 2022

Introduction To establish the responsiveness of the Danish version of the Canadian Occupational Performance Measure (COPM-DK). Method A cross-sectional study was performed in three Danish settings, including 88 clients, 40 men, aged 16–90 years, with a variety of diagnoses. To determine construct responsiveness, the mean changes of the COPM performance and satisfaction score (COPM-P/S) were compared and correlated with the mean changes in the five-item World Health Organization (WHO) Well-Being Index (WHO-5) and the EuroQol–five domains–five levels questionnaire (EQ-5D-5L). To determine the responsiveness, data were analysed with ROC curves to establish the optimal cut-point values for the COPM-DK scores. Minimal important change (MIC) was assessed in relation to anchor-based questions. Results The mean change for COPM-P/S was 3.1 and 3.0, respectively. Small positive correlations were found between the COPM-DK scores and the WHO-5 and EQ-5D-5L scores. The AUC were 0.76 and 0.75, respectively. The optimal cut-point values for the COPM-P/S-scores based on either all positive answers or to the two highest, were 1.2 or 4.20 (COPM-P) and 1.67 or 5.80 (COPM-S), respectively Conclusions The capability of the COPM to detect changes in perceived occupational performance issues is supported. We recommend an MIC on 3.5 points on both scales.
Headaches and the use of personal protective equipment in the general population during the COVID-19 pandemic
Authors: Oliveira Renato , Plácido Madalena , Pereira Liliana , Machado Sara , Parreira Elsa , Gil-Gouveia Raquel 
Published: February 2022

Introduction Headaches associated with personal protective equipment were reported in health-care workers in previous epidemiological studies. Methods National web-based survey advertised by the Portuguese Headache Society and National Headache and Migraine patient´s organization between September-December 2020 screening for personal protective equipment usage pattern, pre-existing and de novo headaches after the onset of the COVID-19 pandemic, and its relation to personal protective equipment use. Results Of 5064 participants, 90.6% (4562/5034) were women, mean age was 37.2 ± 11 years. Most questions had a completion rate above 87% (non-completion rate ranging from 0–12.7%). Twenty percent were health-care professionals (993/5046). Surgical and cloth masks were the most common personal protective equipment type, whereas protective eyewear and FFP2/FFP3 masks were mostly used by health-care professionals. About 97% (1814/1870) of migraine and headache participants reported aggravation of pre-existing headaches with personal protective equipment use, and 56% (2476/4420) had de novo headaches. Participants with de novo headaches had a higher frequency of pre-existing migraine (1118/1226, 91.2% vs 1408/1600, 88%, P = .042), and wore personal protective equipment for longer periods of time (7 ± 2 h 42 vs 6 ± 2 h 54 min per day, P < .001). In multivariate analysis longer mean duration of personal protective equipment use (OR of 1.1, 95% CI 1–1.2) and previous migraine (OR of 1.2, 95% CI 1–1.4) were predictors of developing de novo headaches. Conclusions Almost all participants with pre-existing headache reported worsening of their headaches, and more than half of the study population developed de novo headaches following personal protective equipment use. Duration of personal protective equipment usage and pre-existing migraine were the strongest predictors of de novo headaches.
Post-COVID-19 persistent headache: A multicentric 9-months follow-up study of 905 patients
Authors: Garcia-Azorin David , Layos-Romero Almudena , Porta-Etessam Jesús , Membrilla Javier A , Caronna Edoardo , Gonzalez-Martinez Alicia , Mencia Álvaro Sierra , Segura Tomás , Gonzalez-García Nuria , Díaz-de-Terán Javier , Gallardo Victor J , Gago-Veiga Ana Beatriz , Ballvé Alejandro , Trigo López Javier , Sastre-Real María , Llauradó Arnau , Cornejo Ana , de Lorenzo Íñigo , Guerrero-Peral Ángel , Pozo-Rosich Patricia 
Published: February 2022

Background Headache is a frequent symptoms of coronavirus disease 2019 (COVID-19). Its long-term evolution remains unknown. We aim to evaluate the long-term duration of headache in patients that presented headache during the acute phase of COVID-19. Methods This is a post-hoc multicenter ambisective study including patients from six different third-level hospitals between 1 March and 27 April 2020. Patients completed 9 months of neurological follow-up. Results We included 905 patients. Their median age was 51 (IQR 45–65), 66.5% were female, and 52.7% had a prior history of primary headache. The median duration of headache was 14 (6–39) days; however, the headache persisted after 3 months in 19.0% (95% CI: 16.5–21.8%) and after 9 months in 16.0% (95% confidence interval: 13.7–18.7%). Headache intensity during the acute phase was associated with a more prolonged duration of headache (Hazard ratio 0.655; 95% confidence interval: 0.582–0.737). Conclusion The median duration of headache was 2 weeks, but in approximately a fifth of patients it became persistent and followed a chronic daily pattern.
The clinical characteristics of familial cluster headache
Authors: O’Connor Emer , Nikram Elham , Grangeon Lou , Danno Daisuke , Houlden Henry , Matharu Manjit 
Published: February 2022

Background A positive family history predisposes to the development of cluster headache. The distinct characteristics of familial cluster headache have yet to be confirmed, however, evidence suggests a younger age of onset and higher proportion of females in this subgroup. Objectives To assess the rate and mode of inheritance of familial cluster headache in a tertiary referral centre for headache. To describe the clinical features of familial cluster headache. Methods A retrospective study conducted between 2007 and 2017. Cluster headache was confirmed in probands and affected relatives. Differences in demographics, clinical characteristics, and response-to-treatment in familial cluster headache were delineated through multivariate analysis using a control cohort of 597 patients with sporadic cluster headache. Results Familial cluster headache was confirmed in 48 (7.44%) patients and predominantly reflected an autosomal dominant mode of inheritance with reduced penetrance. Familial cases were more likely to report nasal blockage (OR 4.06, 95% CI; 2.600–6.494, p < 0.001) during an attack and a higher rate of concurrent short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (OR 3.76, 95% CI; 1.572–9.953, p = 0.004). Conclusion These findings add to evidence suggesting a genetic component to cluster headache. Here, we demonstrated prominent nasal blockage, and a higher occurrence of concomitant short-lasting unilateral neuralgiform headache with conjunctival injection and tearing in this subgroup, further delineating the phenotype.
Assisted peritoneal dialysis performed by caregivers and its association with patient outcomes
Authors: Puapatanakul Pongpratch , Kanjanabuch Talerngsak , Tungsanga Kriang , Cheawchanwattana Areewan , Tangjittrong Kittisak , Lounseng Niwat , Songviriyavithaya Phichit , Zhao Junhui , Wang Angela Yee-Moon , Shen Jenny , Perl Jeffrey , Davies Simon J , Finkelstein Fredric O , Johnson David W ,   on behalf of Thailand PDOPPS Steering Groups
Published: February 2022

Background: Although caregivers allow peritoneal dialysis (PD) patients with disabilities the opportunity to perform PD, it is crucial to clarify the safety and effectiveness of assisted PD performed by caregivers compared to self-PD. Methods: PD patients from 22 PD centres in Thailand were prospectively followed in the Peritoneal Dialysis Outcomes and Practice Patterns Study during 2016–2017. Patients receiving assisted PD performed by caregivers were matched 1:1 with self-PD patients using propensity scores calculated by logistic regression. The associations between assisted PD and risk of mortality, peritonitis and permanent transfer to haemodialysis (HD) were assessed by multivariable competing risk regression. Results: Of 778 eligible patients, 447 (57%) required assisted PD performed by caregivers. Most of the caregivers were family members (98%), while the rest were non-family paid caregivers (2%). Patient factors associated with assisted PD were older age, female gender, lower educational level, cardiovascular comorbidities, diabetes, automated PD modality, poorer functional status and lower blood chemistries (albumin, creatinine, sodium, potassium and phosphate). After 1:1 matching, the baseline characteristics were adequately matched, and 269 patients in each group were analysed. Compared with self-PD, assisted PD was significantly associated with an increased risk of all-cause mortality (adjusted sub-hazard ratio: 2.15, 95% confidence interval: 1.24–3.74). There were no differences in the occurrences of peritonitis and permanent HD transfer between the groups. Conclusions: Assisted PD was required by more than half of Thai PD patients and was independently associated with a higher mortality risk. This may reflect causal effect or confounding by indication.
Multiwalled carbon nanotubes reinforced flexible blend nanocomposites membranes for pervaporation separation of aromatic-aliphatic mixtures
Authors: Thomas Saliney , Thomas Shaji , Kadam Sujit A , Jose Thomasukutty , Abraham Jiji , George Soney C. , Thomas Sabu 
Published: February 2022

Multiwalled carbon nanotubes (MWCNT) reinforced NR-NBR blend nanocomposite membranes were prepared and potentially employed for the pervaporation separation of aliphatic – aromatic mixtures. For a 50 wt% benzene feed, the blend nanocomposite membranes had a total flux of 1.265 kgm−2h−1 and separation factor of 1.59 at room temperature. The blend membranes exhibited aromatic selectivity for the separation of aromatic – aliphatic mixtures. 2 phr MWCNT/blend nanocomposite membranes exhibited similar trend for the separation of 10 wt% feed toluene mixture. Trasmission electron microscopy (TEM) images of the blend nanocomposites revealed the well dispersion and distribution of MWCNT in the polymer matrix. The well dispersed MWCNT/blend membranes selectively separate aromatic components from aliphatic – aromatic mixtures.
Evaluation of structural integrity of needle punched banana fiber reinforced industrial safety helmets
Authors: Kenned Jack J , Kumar C. Suresh , Sankaranarayanasamy K. 
Published: February 2022

The purpose of this work is to fabricate and analyse a light weight, recyclable, and non-toxic natural fiber reinforced industrial safety helmet. The fibers were extracted from agro-waste pseudostem of nendran variety banana plant. A facile needle punching technique was employed on banana fibers to produce a needle punched non-woven banana fiber fabric of enhanced mechanical properties without any chemical treatment. Subsequently, the needle punched banana fibers were impregnated with general purpose helmet grade polyester resin in an ISI (Indian standards Institute) endorsed mold to fabricate a needle punched banana fiber helmet (NPBFH). Similarly, 30 mm random banana fiber helmet (RBFH) and glass fiber reinforced helmets (RGFH) were fabricated. The fabricated helmets of 10–50 wt. % fiber content were tested as per ISI standards. The results show that the better properties were achieved at 40 wt. % of fiber content for all varieties of helmets. Significantly, the results revealed that the shock absorption, penetration resistance, and water absorption of NPBFH are 245 kgf, 4.75 mm, and 0.61%, respectively, which is much better than RBFH and comparable with RGFH. This study concluded that the NPBFH (40 wt. %) can be a potential replacement of synthetic fiber reinforced helmets for industrial applications.
A Pilot Observational Exploratory Study of Well-Being in Hospice Interdisciplinary Team Members
Authors: Schneider Catherine , Bristol Alycia , Ford Ariel , Lin Shih-Yin , Brody Abraham A. , Stimpfel Amy Witkoski 
Published: February 2022

Introduction: Well-being and turnover intent represent key aspects to the promotion of a healthy workforce. Alarming levels of burnout and low levels of well-being have been documented in health professionals across care settings. Not only do high levels of burnout, low well-being and high turnover affect health professionals, but they are associated with poor patient care. However, limited research has investigated this topic specifically in hospice interdisciplinary team (IDT) members, nurses, chaplains, social workers. Thus, the purpose of this study was to explore hospice IDT members’ well-being, and turnover intent. Methods: This observational, pilot study used quantitative surveys to examine the well-being, and turnover intention at baseline and at 3 months. Twenty-five hospice IDT members at one site participated. Results: Paired t-tests and percent change demonstrated significant decreases in compassion satisfaction (44.5 vs. 42.1, p = 0.04) and secondary traumatic stress score (18.5 vs. 13.3, p = 0.0001) and a significant increase in burnout score (17.6 vs. 20.5, p = 0.03) from baseline to follow up. Employee turnover slightly decreased from baseline to follow-up. Conclusions: In this pilot study, hospice IDT members had low levels of well-being at baseline that worsened over 3-months indicating a higher potential risk for burnout. Moreover, given the COVID-19 pandemic, this may be an ominous sign of what lies ahead for hospice providers regarding turnover, leading to significant long-term staffing problems in the field. If these results hold true in a larger sample, it could necessitate developing and testing further strategies to ensure a healthy and stable workforce.
Pembrolizumab for advanced non-small cell lung cancer (NSCLC): Impact of autoimmune comorbidity and outcomes following treatment completion
Authors: Ansel Sonam , Rulach Robert , Trotter Nicola , Steele Nicola 
Published: February 2022

Introduction Pembrolizumab, an immune-checkpoint inhibitor, is approved for first-line treatment of metastatic NSCLC in patients with tumours expressing programmed death-ligand 1 (PD-L1) with tumour proportion score (TPS) of ≥50%. We aimed to clarify some uncertainties regarding use of immunotherapy in patients with previous autoimmune (AI) disorders and assess real-world outcomes following treatment completion. Methods We performed a retrospective case record review of 82 patients with tumours expressing PD-L1 at TPS ≥ 50% and receiving first-line Pembrolizumab. Survival was estimated using the Kaplan Meier method. Results After 36.93 months (IQR: 34.37–40.20) median follow-up, median OS was 13.6 months (95% CI 8.9–19.3). There were 10 patients (12%) with AI co-morbidities and there was a trend toward improved median OS for this group versus those without AI comorbidity, 42 months (14.87-NR) versus 10.7 months (7.3–17.8), p = 0.073. Sixteen patients (20%) with nonprogressive disease at 2 years had significantly better median OS compared to those who did not complete 2 years of treatment, NR (42- NR) and 8.7 (5.8–14.1), p < 0.001. Immune related adverse events (irAE) of any grade occurred in 90% of the AI cohort compared with 70.8% of patients without AI comorbidity. Low grade adrenal insufficiency was the only irAE which occurred at a significantly higher rate in the AI group, p = 0.02. Conclusion Patients with previous AI diseases tolerate treatment well, and there is a non-significant trend for improved outcomes in this group. Patients who complete the course of pembrolizumab have significantly better survival outcomes than those who do not.
Evaluation of the Simpson’s Method to Determine Left Ventricular Ejection Fraction Using the Transgastric Two-Chamber View
Authors: Gray Logan , Chen Fei , Teeter Emily G. , Kolarczyk Lavinia M. , Smeltz Alan M. 
Published: February 2022

Introduction Left ventricular chamber size and functional assessment by transesophageal echocardiography can be difficult if visualization is poor in the mid-esophageal views. However, the accuracy of using the Simpson’s method in the transgastric 2-chamber (TG2C) as an alternative approach has not been assessed. Methods The Simpson’s method was performed by 2 independent reviewers using midesophageal 2-chamber (ME2C) and TG2C views. Echocardiographic images were retrieved retrospectively for 49 adult cardiac surgical patients. Results Two-way random effects intraclass correlation coefficients demonstrated no significant interobserver variability. Linear mixed effects models showed no significant differences in ME2C and TG2C measurements with regard to EDV (P=.4407), ESV (P=.5113), or EF (P=.0610). Compared to the ME2C view, the TG2C view had better image quality of the LV walls (image quality score median [interquartile range]: 2.00 [.00] vs 1.00 [1.00]; P<.0001), but worse image quality of the mitral annulus (1.00 [1.00] vs 2.00 [.00]; P<.0001) and LV apex (.00 [1.00] vs 2.00 [1.00]; P<.0001). Conclusions This study suggests the Simpson’s method can be applied to the TG2C view as an alternative to the standard midesophageal method to estimate chamber volumes and EF.
Outcome after early thrombotic occlusion of arteriovenous fistulas
Authors: Mo Hyejin , Ahn Sanghyun , Han Ahram , Min Sangil , Min Seung-Kee , Jung In Mok 
Published: February 2022

Objective: Arteriovenous fistulas (AVFs) are considered the first choice for venous access in end-stage renal disease patients, however, they are also known to have a high primary failure rate (early thrombosis and maturation failure). Of these, the outcome of thrombosed immature AVFs is not well known. This study aimed to investigate the outcome of AVFs with early thrombosis. Methods: Patients who underwent AVF creation from January 2009 to December 2019 at Seoul National University Hospital or Seoul Metropolitan Government – Seoul National University Boramae Medical Center were retrospectively reviewed. Patients who received salvage operations due to early thrombosis within 30 days after access creation were analyzed. Results: During the study period, a total of 45 patients (radiocephalic 26; brachiocephalic 19) developed early thrombosis and underwent salvage operations. The median age of patients was 61.0 (54.5–69.5) years, and 51.1% were male. The first salvage operation was performed on the median 1.0 (0.0–4.5) day after AVF creation. The most common cause for early thrombosis was venous stenosis (64.4%) and followed by poor arterial inflow (28.9%), especially in radiocephalic AVFs. About 20 AVFs were salvaged to maturation (46.5%). Post-salvage primary patency and secondary patency at 1 year was 72.6% and 100%. In a multivariate logistic regression, significant risk factors for maturation failures were minimum venous outflow diameter ⩽2.5 mm (OR, 4.433; 95% CI, 1.039–18.921; p = 0.044) and lower in patients with hypertension (OR, 0.064; 95% CI, 0.006–0.637; p = 0.019). Conclusions: Thrombosed immature AVFs are associated with a high failure rate after salvage operation. However, if the salvage operation is successfully performed, it is associated with an acceptable 1-year outcome.
Psychometric properties of the Portuguese teacher-version of the Inventory of Callous-Unemotional Traits
Authors: Figueiredo Patrícia , Moreira Diana , Ramião Eduarda , Barroso Ricardo , Barbosa Fernando 
Published: February 2022

Callous unemotional (CU) traits refer to specific deficits in affective experience and interpersonal style, characterized by absence of guilt, constrictive display of emotion and failure to show empathy, callous use of others for one’s own gain. The Inventory of Callous-Unemotional Traits (ICU) was developed to measure CU traits in children and adolescents. The aim of this study was to analyze the factorial structure of the Portuguese version of teacher-report ICU for children in school age and examine psychometric properties such as internal consistency and convergent validity in a community sample. Thirty-six teachers provided behavioral ratings of 100 and 78 children of elementary school, 88 boys and 90 girls, aged between 6 and 10 years old. Confirmatory factor analyses provided further support to a 2-factor structure, comprising the following dimensions: callous and uncaring. This study showed that the ICU seems a reliable an accessible tool that can be used in the Portuguese educational context to evaluate CU traits with low time consumption.
Depressive symptoms are no longer a barrier to HCV treatment initiation in the HIV–HCV co-infected population in Canada
Authors: Marathe Gayatri , Moodie Erica E M , Brouillette Marie-Josée , Cox Joseph , Delaunay Charlotte Lanièce , Cooper Curtis , Hull Mark , Gill John , Walmsley Sharon , Pick Neora , Klein Marina B ,   Canadian Co-Infection Cohort
Published: February 2022

Background Psychiatric illness was a major barrier for HCV treatment during the Interferon (IFN) treatment era due to neuropsychiatric side effects. While direct acting antivirals (DAA) are better tolerated, patient-level barriers persist. We aimed to assess the effect of depressive symptoms on time to HCV treatment initiation among HIV–HCV co-infected persons during the IFN (2003–2011) and second-generation DAA (2013–2020) eras. Methods We used data from the Canadian Co-infection Cohort, a multicentre prospective cohort, and its associated sub-study on Food Security (FS). We predicted Center for Epidemiologic Studies Depression Scale-10 (CES-D-10) classes for depressive symptoms indicative of a depression risk using a random forest classifier and corrected for misclassification using predictive value-based record-level correction. We used marginal structural Cox proportional hazards models with inverse weighting for competing risks (death) to assess the effect of depressive symptoms on treatment initiation among HCV RNA-positive participants. Results We included 590 and 1127 participants in the IFN and DAA eras. The treatment initiation rate increased from 9 (95% confidence interval (CI): 7–10) to 21 (95% CI: 19–22) per 100 person-years from the IFN to DAA era. Treatment initiation was lower among those with depressive symptoms compared to those without in the IFN era (hazard ratio: 0.81 (95% CI: 0.69–0.95)) and was higher in the DAA era (1.19 (95% CI: 1.10–1.27)). Conclusion Depressive symptoms no longer appear to be a barrier to HCV treatment initiation in the co-infected population in the DAA era. The higher rate of treatment initiation in individuals with depressive symptoms suggests those previously unable to tolerate IFN are now accessing treatment.
Smartphones as personal digital archives? Recentring migrant authority as curating and storytelling subjects
Authors: Georgiou Myria , Leurs Koen 
Published: February 2022

This article addresses the smartphone as a complicated technology of forced migration: a device that accompanies those who move, but which also records and catalogues digital traces within life contexts of conflict, uprooting, migration and resettlement. We conceptualise smartphones as personal digital archives: migrants’ curation of their own stories on their own portable devices. Personal digital archives, we argue, reflect the migrant gaze and constitute mobile subaltern subjects’ record of forced migration. Inductively learning from fieldwork conducted across five sites over 5 years, we analyse how the personal digital archive records and reflects the mediation of migration in its three dimensions: symbolic, affective and material. By focussing on personal digital archives, we recentre the authority of migrants as witnessing subjects of their own life stories. Their archives as autonomous migrant records provide a powerful basis to reflect upon and potentially contest mainstream western journalism cultures, which too often reduce migration to a spectacle and the migrant to a dehistoricised figure with little agency or voice.