bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upravljanje proizvodnega sistema z zakasnitvami v proizvodnji s pomočjo Lambertovih funkcij
Authors: Pušenjak Rudolf , Oblak Maks 
Published: August 2022

Članek obravnava upravljanje proizvodnega procesa z zakasnitvami v proizvodnji. Namen upravljanja proizvodnega sistema je optimiranje količine proizvodnje tako, da zmanjšamo proizvodne stroške v izbranem časovnem obdobju na minimum. Upravljanje je prikazano v enostavnem proizvodnem sistemu z zakasnitvami, v katerem poteka neprekinjena proizvodnja posameznega izdelka. Za doseganje optimalne proizvodnje so v prispevku uporabljene Lambertove funkcije, s katerimi omogočimo tvorbo analitičnih rešitev linearne diferencialne enačbe z zakasnitvami, ki opisuje proizvodni proces. V članku je raziskana stabilnost upravljanja proizvodnega sistema z določitvijo stabilnostne meje v analitični obliki. Pri tem je ugotovljeno, da zakasnitve proizvodnje povzročajo nihajoči potek dejanskih zalog v odvisnosti od časa, pri čemer z upravljanjem proizvodnje ta nihanja uspešno zadušimo, v kolikor se časovna zakasnitev in stopnja načrtovane proizvodnje na osnovi informacije o pogrešku regulacije nahajata v stabilnem področju. Dobljeni analitični rezultati so primerjani z numerično rešitvijo po metodi Runge-Kutta v programskem okolju Mathematica, pri čemer je ugotovljeno skoraj popolno ujemanje.
Sinteza aktivnih komponent za zdravila z gensko spremenjenimi rastlinami
Authors: Luthar Zlata 
Published: August 2022

V zadnjih letih so izsledki na področju kliničnih testiranj rekombinantnih zdravil pridobljenih z gensko spremenjenimi (GS) rastlinami doživeli velik razcvet. V ta namen so bili uspešno opravljeni številni poskusi povečanja izražanja antigenov za zdravljenje nalezljivih virusnih in bakterijskih bolezni. Najnovejše raziskave so osredotočene v optimizacijo sinteze in pridobivanja antigenov za zdravljenje avtoimunih in genetskih bolezni. Razmišlja pa se tudi v smer sinteze antigenov za zdravljenje tropskih bolezni. Vedno več je izsledkov o uporabi zdravil z zaužitjem svežega rastlinskega materiala (predvsem v veterini). Komponentna cepiva pridobljena z GS rastlinami so sposobna vzbuditi močnejši imunski odziv in izzvati imunski spomin za daljše časovno obdobje. Njihovo pridobivanje je povezano z manjšimi proizvodnimi stroški. Kljub vsem raziskavam in dosežkom pa nobeno od zdravil pridobljeno z GS rastlinami ni prisotno na trgu. Za dosego tega bo potrebno odpraviti težave povezane s proizvodnjo, uporabo, predvsem pa z biološko varnostjo in splošnim mnenjem javnosti do GS rastlin.
Antipsychotic drugs and QT interval prolongation
Authors: Novak Šarotar Brigita 
Published: August 2022

Prolongation of myocardial repolarization, i.e. lengthening of the QTc interval on surface electrocardiogram (ECG), with increased risk of cardiac arrhythmias, has been recognized as a side effect of many drugs. Most first and second generation antipsychotic drugs can cause dose-related prolongation of QTc, although there are important differences in the potency of individual agents. ECGs in 46 patients suffering from schizophrenic disorder and treated with different antipsychotic drugs one week after the admission to the psychiatric hospital were analyzed in this prospective observational study. Hearth rate, QT interval and QTc interval were assessed. The average daily dose of prescribed antipsychotic drugs was calculated. Average QTc interval was 417 msec, only 3 out of 46 (6,5%) patients had QTc over 450 msec and only one patient (2,2%) had QTc over 500 msec. No differences in QTc interval between patients who were treated either with first or second generation antipsychotic drug or with combination of both were found. Female participants had significantly longer OTc interval than male participants (p < 0,05). Results raise the question of the clinical relevance of a single ECG for diagnostics of cardiac complications in schizophrenia patients and suggest the need to conduct ECG monitoring in patients with high risk for cardiac complications during antipsychotic treatment.
Uporaba različnih dodatkov pri izdelavi slivove marmelade
Authors: Unuk Tatjana , Fartek Doroteja , Grobelnik Mlakar Silva 
Published: August 2022

Na Fakulteti za kmetijstvo in biosistemske vede Univerze v Mariboru smo ugotavljali, kako različni dodatki v slivovi marmeladi vplivajo na senzorično oceno marmelad. Kot osnovno surovino smo uporabili slive sorte 'Čačanska lepotica', kot dodatke pa mlete klinčke, mleti ingver in mleto pomarančno lupino v podmerku 6 g/L. Namerno smo izbrali dodatke, ki so aromatični in imajo hkrati dokazane antioksidativne lastnosti. V začetku junija 2017 smo izvedli senzorično ocenjevanje z uporabo hedonskega testa, kjer so preskuševalci ocenjevali všečnost vonja, barve, okusa, konsistence, razmerja med sladkor/kislina ter skupni vtis posameznih vzorcev. Hkrati so se preizkusili tudi v prepoznavanju dodatkov. Rezultati senzoričnega ocenjevanja kažejo, da dodatki statistično značilno vplivajo na oceno všečnosti barve, okusa, razmerja sladkor/kislina ter skupni vtis posameznega vzorca. Najboljšo skupno oceno je prejel vzorec marmelade z dodatkom pomarančne lupine, najslabšo pa vzorec z dodatkom klinčkov. Hipotezo, da bodo preskuševalci najboljšo oceno dodelili poznanemu okusu, smo ovrgli.
Nanotehnologija v postopkih precizijskega litja plemenitih zlitin
Authors: Rudolf Rebeka , Majerič Peter , Ferčec Urban 
Published: August 2022

Precizijsko litje je postopek, ki temelji na ulivanju in strjevanju taline na »odstranjeni vosek«1. Prednosti precizijskega litja so visoka natančnost, gladkost površine ter celovitost izdelanih odlitkov, vse značilnosti pa se lahko uporabijo tudi v nanotehnologiji2. Tako izdelani odlitki iz zlitin kobalta, kroma, titana in srebra/zlata so že vrsto let poznani kot biokompatibilni materiali z izjemnimi elastičnimi lastnostmi3 in se uporabljajo na področjih ortopedije in zobozdravstva ter pri izdelavi mnogih medicinskih naprav4. Po drugi strani so danes zelo uporabljeni nanodelci plemenitih kovin in to predvsem na osnovi na zlata. Ti izkazujejo edinstvene fizikalne in kemijske lastnosti, kot so velika reakcijska površina, dobra absorpcija in prevodnost5. Ker zlitine na osnovi zlata oziroma srebra na makro-nivoju izkazujejo izrazito drugačne lastnosti kot nanodelci zlata in srebra na mikro nivoju, so slednji predmet mnogih novejših raziskav in posledično številnih novih aplikacij6,7,8. Vendar pa se večina raziskav na področju precizijskega litja plemenitih kovin ne osredotoča na nanotehnologijo, ki predstavlja velik raziskovalni potencial. Z uporabo nanotehnologije oziroma izboljšanega prezicijskega litja bi tako pridobili popolnoma nove lastnosti materialov, uporabne na številnih področjih s prvenstvenim ciljem v medicini. Predstavitev tega pristopa in kategorizacija teh postopkov je tako glaven cilj dela v katerem je predstavljen nov postopek izdelave zlitin in karakterizacijo njihovih lastnosti, kar predstavlja pomembno iztočnico za prihodnje raziskave.
Video annotation with metadata: A case study of soccer game video annotation with players
Authors: Zimšek Danilo , Banfi Luka , Sepesy Maučec Mirjam 
Published: August 2022

In recent years, the use of convolutional neural networks for video processing has become very attractive. The reason lies in the computational power for data processing which is available today. There are many well-defined research areas where neural networks have brought higher reliability than other conventional approaches; for example, traffic sign recognition and isolated number recognition. In this paper, we will describe the architecture and the implementation of the process of soccer game annotation. The game is annotated with data about players. The technology of convolutional neural networks is used for number recognition. The process runs in real-time on a streaming video. Content enriched with metadata is given to the user in parallel with the real-time video. In the paper, we will describe in some detail the following modules: Image binarization, shot localization, the selection and recognition of numbers on players` jerseys.
Hemodiyaliz Hastalarında Mortaliteye Etkisi Olan Kan Parametreleri ve Ekokardiyografi Bulguları
Authors: ALANLI Recep , KÜÇÜKAY Murat Bülent , MÜRSEL Şahin , YAVUZ İzzet , KAYMAKAMTORUNLARI DENİZ Fatma , KASKATI Osman Tolga , YILDIRIMKAYA Metin 
Published: August 2022

Giriş: Bu çalışmada hemodiyalize giren hastaların demografik özellikleri, eşlik eden hastalıkları, kan parametreleri ve EKO bulguları ile mortalite arasındaki ilişkinin saptanması hedeflendi.
Gereç ve Yöntem: Bu çalışma; Temmuz 2017 ile Temmuz 2021 tarihleri arasında kronik böbrek hastalığı nedeniyle düzenli hemodiyalize giren 755 hasta ile retrospektif olarak yapıldı. Onsekiz yaşından küçükler ve 60 günden az hemodiyalize girenler çalışmaya alınmadı.
Bulgular: C- reaktif protein, ferritin, eritrosit dağılım hacmi, alkalen fosfataz yüksekliği, 65 yaşından büyük olmak, albumin, kalsiyum, protein eksikliği ve ejeksiyon fraksiyonu (EF) düşüklüğü ile ölüm arasında ilişki olduğu saptandı. Yaş, albümin düzeyi, hipertansiyon, hiperlipidemi ve EF düzeyleri ile mortalite arasında korelasyon bulundu.
Sonuç: Hemodiyalize giren hastalarda; ileri yaş, albumin eksiliği ve EF düşüklüğü ile hiperlipidemi varlığında mortalite riski yüksek olup, bu hastaların daha dikkatli takip edilmesi gerekmektedir. Ayrıca antihipertansif ilaçların koruyucu özelliği olup, uygun olan her hastaya antihipertansif ilaç verilmesi önerilir.
The Reduction in Medical Errors on Implementing an Intensive Care Information System in a Setting Where a Hospital Electronic Medical Record System is Already in Use: Retrospective Analysis
Authors: Seino Yusuke , Sato Nobuo , Idei Masafumi , Nomura Takeshi 
Published: August 2022

Background
Although the various advantages of clinical information systems in intensive care units (ICUs), such as intensive care information systems (ICISs), have been reported, their role in preventing medical errors remains unclear.

Objective
This study aimed to investigate the changes in the incidence and type of errors in the ICU before and after ICIS implementation in a setting where a hospital electronic medical record system is already in use.

Methods
An ICIS was introduced to the general ICU of a university hospital. After a step-by-step implementation lasting 3 months, the ICIS was used for all patients starting from April 2019. We performed a retrospective analysis of the errors in the ICU during the 6-month period before and after ICIS implementation by using data from an incident reporting system, and the number, incidence rate, type, and patient outcome level of errors were determined.

Results
From April 2018 to September 2018, 755 patients were admitted to the ICU, and 719 patients were admitted from April 2019 to September 2019. The number of errors was 153 in the 2018 study period and 71 in the 2019 study period. The error incidence rates in 2018 and 2019 were 54.1 (95% CI 45.9-63.4) and 27.3 (95% CI 21.3-34.4) events per 1000 patient-days, respectively (P<.001). During both periods, there were no significant changes in the composition of the types of errors (P=.16), and the most common type of error was medication error.

Conclusions
ICIS implementation was temporally associated with a 50% reduction in the number and incidence rate of errors in the ICU. Although the most common type of error was medication error in both study periods, ICIS implementation significantly reduced the number and incidence rate of medication errors.

Trial Registration
University Hospital Medical Information Network Clinical Trials Registry UMIN000041471; https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000047345
Melatonin for Neuropathic Pain: Protocol for a Double-blind, Randomized Controlled Trial
Authors: Gilron Ian , Tu Dongsheng , Holden Ronald R , Moulin Dwight E , Duggan Scott , Milev Roumen 
Published: August 2022

Background
Neuropathic pain (NP), a complication of several conditions (eg, diabetic neuropathy and varicella zoster), is a common challenging problem, and there is a growing need to develop safe and effective nonopioid treatments. Sleep disturbance is commonly associated with NP because pain intensity in NP conditions is often worse at night. The pineal hormone melatonin has been shown to reduce pain in both preclinical and clinical settings, in addition to multiple trials demonstrating efficacy for primary insomnia and delayed sleep phase syndrome.

Objective
We propose to conduct a clinical trial to evaluate the efficacy and safety of melatonin for NP.

Methods
Using a double-blind, placebo-controlled, crossover design, 30 adults with NP will be randomly allocated to one of two sequences of treatment with melatonin and placebo. During each of the two treatment periods, participants will take capsules containing melatonin or placebo for 4 weeks, followed by a 7-day washout period. The primary outcome will be mean daily pain intensity (scored 0-10) at maximally tolerated doses (MTDs) during each period. Secondary outcomes, assessed at MTDs, will include global improvement, adverse events, mood, and quality of life.

Results
This trial was registered in the International Standard Randomized Controlled Trial registry May 4, 2022 (ISRCTN #16215617), attained conditional ethics approval May 9, 2022 (Queen’s University Health Sciences & Affiliated Teaching Hospitals Research Ethics Board protocol number ANAE-387-22), and recruitment is set to start August 2022.

Conclusions
This trial will provide rigorous evidence comparing the efficacy of melatonin to that of placebo in the treatment of NP.

Trial Registration
ISRCTN Registry 16215617; https://www.isrctn.com/ISRCTN16215617

International Registered Report Identifier (IRRID)
PRR1-10.2196/40025
SISTEM INFORMASI MANAJEMEN LAYANAN KEARSIPAN (SI MALAK) BERBASIS WEB
Authors: Fajar Moh Malik , Chotijah Umi 
Published: August 2022

Abstrak. Pandemi COVID-19 yang telah terjadi dalam kurun waktu 2 (dua) tahun membuat masyarakat enggan untuk beraktifitas diluar rumah. Dengan munculnya varian yang bernama delta yang ditemukan di benua Afrika Selatan pada pertengahan tahun 2021 serta ditambah dengan muncul varian terbaru yang bernama omicron yang ditemukan pada akhir tahun 2021 semakin membuat masyarakat lebih membatasi aktifitas di luar rumah. Pemerintah telah melakukan terobosan – terobosan baru demi menekan angka covid-19 agar tidak melonjak. Pandemi coronavirus diseases (COVID-19) yang terjadi di indonesia membuat Pemerintah Kabupaten Gresik khususnya Dinas Perpustakaan dan Kearsipan Kabupaten Gresik sebagai pelayanan langsung terhadap masyarakat kurang efektif dan efisien. Dalam hal ini untuk meningkatkan pelayanan dimasyarakat maka peneliti membuat sebuah Sistem Informasi Manajemen Layanan Kearsipan (SI MALAK) Berbasis Web yang dapat digunakan sebagai tombak pelayanan terhadap masyarakat untuk tidak selalu mengandalkan datang ditempat serta mengurangi kontak langsung antara manusia. Pembuatan sistem menggunakan metode waterfall dan menggunakan bahasa pemograman PHP serta MySQL sebagai database. Hasil dalam pengujian sistem menunjukkan bahwa semua fitur sistem bekerja dengan baik dan diterima oleh pengguna/ masyarakat.
ANALISIS PENGEMBANGAN MODEL PREDIKSI KESUKSESAN KICKSTARTER MENGGUNAKAN ALGORITMA BACKPROPAGATION DAN RANDOM FOREST
Authors: Agustina Indria , Mulyani Yessi , Septiana Trisya , Mardiana Mardiana 
Published: August 2022

Model prediksi ini dibangun dengan pendekatan klasifikasi pada data mining dengan algoritma backpropagation ANN dan random forest . Kategori tingkat kesuksesan dibagi menjadi dua yaitu tidak sukses, dan sukses. Selanjutnya model prediksi dikembangkan berdasarkan variabel-variabel informasi yang ada, dimana model dikembangkan dalam dua tahap. Tahap pertama, model prediksi dikembangkan dengan 10 variable (9 variabel sebagai input dan 1 variabel sebagi laebl) yang ada pada dataset. Kemudian pada tahap kedua hanya 8 variabel (7 variabel sebagai input dan 1 variabel sebagai label), dikurangi variabel-variabel tentang pledge dan backers pada pengembangan model prediksi. Pengembangan model prediksi ini menggunakan 5723 data campaign kategori teknologi dari portal Kickstarter. Model pertama menggunakan algoritma backpropagation ANN dan random forest memberikan akurasi tertinggi masing-masing sebesar (89%, 98%) Sedangkan model kedua memberikan akurasi tertinggi masing-masing sebesar (69%, 65.7%) Hasil penelitian tersebut menunjukkan bahwa pengurangan variabel pledge dan backers dapat menurunkan performa model prediksi. Berkaitan dengan pemanfaatan, 2 model prediksi tahap pertama dan kedua adalah sebagai perbandingan. Dan dari data yang sudah didapat dapat disimpulkan bahwa model yang akan dipakai untuk memprediksi kesuksesan kickstarter adalah model pertama dengan menggunakan algoritma rando forest yang merupakan model terbaik dengan nilai akurasi 98% dan nilai f1-score nya 98%.
Creating and Evolution Centralized Scientific Journals Remote Access System for Information Support of Russian Scientific Research
Authors: Glushanovskiy A. V. 
Published: August 2022

The article considers the system of information support of Russian scientific research in the field of natural sciences process. It’s gradual creating and development based on the creation of hybrid scientific library, using both the local (located directly in the library) traditional collection, and collections of electronic full-text media available remotely to the library patron and being a virtual part of the whole library collection.The article deals with the use of scientific journals (mainly foreign) as the most important part of the scientific resources required by Russian scientists’ access. The analysis is based on the Library for Natural Sciences of the Russian Academy of Sciences (one of the leading scientific libraries in Russia) example.The mentioned process started in the last centuries 1990s, and, as shown in the article, passes through several stages. From the very beginning, the process required for the libraries to unite into associations for the electronic resources joint use. These associations took, in accordance with international experience, the form of library consortia. At the first stage, consortia were created to bring together several libraries to access the electronic resources of a single foreign library.This system turned out to be viable, but rather cumbersome for a library (for effective work a library has to be a member of several consortia, which turned out to be non-technological). At the next stage, a single consortium was created with the support of the Russian Foundation for Basic Research — Scientific Electronic Library RFBR. Further development required the direct state on the one of the Ministry of Higher Education and Science projects basis support. This process went through several development stages (using as a project operator consortium NEICON, the RNPLS&T and again RFBR — at another level of organization and funding).As a result, by 2020 the providing mainly information support for the work of the main mass of scientific and educational institutions in the specified field system was created and debugged on the practical level. By the early 2020s, the work had entered a more or less stable working mode.The issues requiring an urgent solution are the lack of an insurance copy of resources purchased abroad, which creates an uncertain situation in the event of the relationship with the resource owner termination, and the absence, in full, of a similar access to Russian scientific resources system, if their publication rights, in part, have been transferred to foreign publishers.
<strong>The increasing risk of temporomandibular disorder and articular eminence inclination due to tooth loss</strong>
Authors: Chairunnisa Ricca , Harahap Rahmadhani 
Published: August 2022

ABSTRACTIntroduction: Tooth loss leads to increased biomechanical pressure in the temporomandibular joint due to changes in the functional movement pattern of the jaw, resulting in joint structure damage specifically change of the articular eminence inclination (AEI) angle, which is one of the increased risks of the temporomandibular disorder (TMD). This study aimed to analyze the relationship between the number and quadrants of tooth loss on TMD and the AEI. Methods: It was descriptive-analytic study using a cross sectional design. The study was done in Universitas Sumatera Utara (USU) Dental hospital, conducted questionnaires and panoramic radiographic on 42 subjects aged over 18-64 years with tooth loss. Data analyzed used Chi-square analysis. Results: The prevalence of TMD on the ≥3 tooth loss group by 82.6% and the four-quadrant group by 93.8%. The prevalence of change in the AEI on the ≥3 tooth loss group was 34.8% on the flat right side, while on the left side of 26.1% was flat, and 13% was steep. Based on the number of quadrants tooth loss, the highest was on the four-quadrant group by 50% on flat right side, and on the three-quadrant group was 25% flat, 25% steep on the left side. There was a significant relationship between the number of tooth loss (p=0.023), the number of tooth loss quadrants, and TMD (p=0.016). There was no relationship between the number of tooth loss and the AEI, except for the number of tooth loss quadrants and the AEI on the right side with a significant result (p=0.017). Conclusion: There was relationship between the number of tooth loss, the number of tooth loss quadrants, and TMD and there was no relationship between the number of tooth loss and the AEI, except for the number of tooth loss quadrants and the AEI on the right side.Keywords: Edentulous; tooth loss; temporomandibular disorder; inclination of articular eminence.
<strong>Centrifugation effect on size distribution of organic dental filler made from glutinous rice flour</strong>
Authors: Takarini Veni , Asri Lia Amelia Tresna Wulan , Djustiana Nina , Hadi Bambang Kismono 
Published: August 2022

ABSTRACTIntroduction: Organic fillers made from the green-synthesis process can be utilized in dental treatment due to their non-toxic characteristic of the oral environment. Dental fillers must be smaller to improve their mechanical, physical, and biological properties. Material processing and centrifugation contribute to the size of processed materials. This study evaluates the effect of different centrifugation speeds on the size and distribution of glutinous rice flour as organic dental filler. Methods: This experimental study uses glutinous rice flour suspended in water and then centrifuged at different speeds of 3000 and 6000 rpm compared to untreated glutinous rice flour as control. The particle size was examined using Scanning Electron Microscope (SEM) and Dynamic Light Scattering (DLS). Next, Fourier Transform Infra Spectroscopy (FTIR) and X-ray Diffraction (XRD) were performed to evaluate whether there were structure and crystallinity changes. Finally, the cytocompatibility of fillers was examined by a cell viability test. Results: Centrifugation of glutinous rice flour at 3000 rpm resulted in smaller average size particles, evenly distributed, and higher crystallinity than other groups. There were no changes in functional groups, as shown by FTIR spectra. However, the processed samples were more amorphous compared to the control. Importantly, the processed samples appeared to be non-toxic, with a range of cell viability of 82.75-86.67% after 24 h incubation. Conclusion: Centrifugation speed of 3000 rpm has decreased in size, and a more homogenous particle size of organic filler made from glutinous rice flour. Importantly, it improved the cytocompatibility of particles compared to untreated control. Altogether, we proposed this organic material as a new potential material in the dental application that can be further investigated. Keywords: centrifugation speed; size distribution; organic dental filler; glutinous rice flour