bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics and prognosis of elderly patients with anal cancer
Authors: Wang Xiaogan , Xiang Nengjun , Xu Xuemei , Chen Hongjin 
Published: November 2022

Abstract
Purpose. The clinical characteristicsand prognosis of anal cancer in the elderly have not received sufficient attention. The study aimed to evaluate the clinical features and prognostic factors of elderly patients with anal cancer.
Method. The characteristics of anal cancer patients (aged <65 and ≥65) diagnosed during 2004-2017 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was used to correct age bias caused by assessed confounders. The chi-squared (χ2) test was used to assess differences in categorical variables of characteristics between two age groups., The Kaplan-Meier survival technique, Log-rank test, Cox regression, and nomogram were used for survival analysis.
Results.The receipt of adjuvant age increases the risk of overall survival by 86% after propensity-score matching (HR=1.86, 95%CI=1.70-2.03,P<0.001). The proportion of unmarried status and adenocarcinoma tissue was significantly higher in the elderly than in the younger group. COX regression analysis shows older age, non-squamous cell carcinoma, unmarried status, and advanced AJCC stage as independent risk prognostic factors for anal cancer in the elderly. The effects of chemotherapy, radiotherapy, and surgery all improved the prognosis of the elderly. Besides, senior score and survival probability could be accomplished by our nomogram with a c-index of 0.7179.
Conclusion. Relatively low rates of chemoradiation and relatively conservative therapy regimens are associated with a poorer prognosis in elderly anal cancer. At the same time, surgery has a potential role in improving the prognosis of elderly anal cancer patients.
Comparison of Integrin αvβ3 Expression with 68 Ga-NODAGA-RGD PET/CT and Glucose Metabolism with 18F-FDG PET/CT in Esophageal or Gastroesophageal Junction Cancers
Authors: Matthieu Dietz , Vincent Dunet , Mantziari Styliani , Pomoni Anastasia , Correia Ricardo Dias , Dardel Nathalie Testart , Boughdad Sarah , Lalonde Marie Nicod , Treglia Giorgio , Schaefer Markus , Schaefer Niklaus , Prior John 
Published: November 2022

Abstract
Background
The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of 68Ga-NODAGA-RGD PET/ CT with that of 18F-FDG PET/CT regarding tumoral uptake and distribution, as well as histopathologic examination.
Methods
Ten 68Ga-NODAGA-RGD and ten 18F-FDG PET/CT were performed in nine prospectively included participants (1 woman; aged 58±8.4 y, range 40–69 y). Maximum SUV (SUVmax) and metabolic tumor volumes (MTV) were calculated. The Mann-Whitney U test and Spearman correlation analysis (ρ) were used.
Results
68Ga-NODAGA-RGD PET/CT detected positive uptake in 10 primary sites (8 for primary tumors and 2 for local relapse suspicion), 6 lymph nodes and 3 skeletal sites. 18F-FDG PET/CT detected positive uptake in the same sites but also in 16 additional lymph nodes and 1 adrenal gland. On a lesion-based analysis, SUVmax of 18F-FDG were significantly higher than those of 68Ga-NODAGA-RGD (4.9 [3.7–11.3] vs. 3.2 [2.6–4.2] g/mL, p = 0.014). Only 1 participant showed a higher SUVmax in an osseous metastasis with 68Ga-NODAGA-RGD as compared to 18F-FDG (6.6 vs. 3.9 g/mL). Correlation analysis showed positive correlation between 18F-FDG and 68Ga-NODAGA-RGD PET parameters (ρ = 0.56, p = 0.012 for SUVmax, ρ = 0.78, p < 0.001 for lesion-to-background ratios and ρ = 0.58, p = 0.024 for MTV). We observed that 18F-FDG uptake was homogenous inside all the confirmed primary sites (n = 9). In contrast, 68Ga-NODAGA-RGD PET showed more heterogenous uptake in 6 out of the 9 confirmed primary sites (67%), seen mostly in the periphery of the tumor in 5 out of the 9 confirmed primary sites (56%), and showed slight extensions into perilesional structures in 5 out of the 9 confirmed primary sites (56%).
Conclusions
In conclusion, 68Ga-NODAGA-RGD has lower potential in the detection of esophageal or esophagogastric junction malignancies compared to 18F-FDG. However, the results suggest that PET imaging of integrin αvβ3 expression may provide complementary information and could aid in tumor diversity and delineation.
Trial registration: Trial registration: NCT02666547. Registered January 28, 2016 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02666547
SNP+ to predict dropout rates in SNP arrays
Authors: Sastre Natalia , Mercadé Anna , Casellas Joaquim 
Published: November 2022

Abstract
Genotyping individuals using forensic or non-invasive samples such as hair or fecal samples increases the risk of allelic amplification failure (dropout) due to the low quality and quantity of DNA. One way to decrease genotyping errors is to increase the number of replicates per sample. Here, we have developed the software SNP+ to estimate the dropout probability and the subsequent required number of replicates to obtain the reliable genotype with probability 95%. Moreover, the software predicts the minor allele frequency and compares two competing models assuming equal or allele-specific dropout probabilities by a Bayes factor. The software handles data from one SNP to high density arrays (e.g., 100,000 SNPs).
A multi-species evaluation of digital wildlife monitoring using the Sigfox IoT network
Authors: Wild Timm A. , Schalkwyk Louis van , Viljoen Pauli , Heine Georg , Richter Nina , Vorneweg Bernd , Koblitz Jens C. , Dechmann Dina K. N. , Rogers Will , Partecke Jesko , Linek Nils , Volkmer Tamara , Gregersen Troels , Havmøller Rasmus W. , Morelle Kevin , Daim Andreas , Wiesner Miriam , Wolter Kerri , Fiedler Wolfgang , Kays Roland , Ezenwa Vanessa O. , Meboldt Mirko , Wikelski Martin 
Published: November 2022

Abstract
Bio-telemetry from small tags attached to animals is one of the principal methods for studying the ecology and behaviour of wildlife. The field has constantly evolved over the last 80 years as technological improvement enabled a diversity of sensors to be integrated into the tags (e.g., GPS, accelerometers, etc.). However, retrieving data from tags on free-ranging animals remains a challenge since satellite and GSM networks are relatively expensive and or power hungry. Recently a new class of low-power communication networks have been developed and deployed worldwide to connect the internet of things (IoT). Here, we evaluated one of these, the Sigfox IoT network, for the potential as a real-time multi-sensor data retrieval and tag commanding system for studying fauna across a diversity of species and ecosystems. We tracked 312 individuals across 30 species (from 25 g bats to 3 t elephants) with seven different device concepts, resulting in more than 177,742 successful transmissions. We found a maximum line of sight communication distance of 280 km (on a flying cape vulture [Gyps coprotheres]), which sets a new documented record for animal-borne digital data transmission using terrestrial infrastructure. The average transmission success rate amounted to 68.3% (SD 22.1) on flying species and 54.1% (SD 27.4) on terrestrial species. In addition to GPS data, we also collected and transmitted data products from accelerometers, barometers, and thermometers. Further, we assessed the performance of Sigfox Atlas Native, a low-power method for positional estimates based on radio signal strengths and found a median accuracy of 12.89 km (MAD 5.17) on animals. We found that robust real-time communication (median message delay of 1.49 s), the extremely small size of the tags (starting at 1.28 g without GPS), and the low power demands (as low as 5.8 µAh per transmitted byte) unlock new possibilities for ecological data collection and global animal observation.
Relevance of financial development and fiscal stability in dealing with disasters in Emerging Economies
Authors: Terrones Valeria , Tol Richard S.J. 
Published: November 2022

Abstract
Previous studies show that natural disasters decelerate economic growth, and more so in countries with lower financial development. We confirm these results with more recent data. We are the first to show that fiscal stability reduces the negative economic impact of natural disasters in poorer countries, and that catastrophe bonds have the same effect in richer countries.
JEL Classification E17, E62, G00, G20, H30, Q54
To Scope or not to Scope; Value of Routine Colonoscopy after Uncomplicated Diverticulitis in Switzerland. A Retrospective Cohort Study
Authors: Hess Gabriel Fridolin , Gnägi Cornelia Regula , Seppey Romain Luca , Viehl Carsten Thomas 
Published: November 2022

Abstract
Purpose
Diverticular disease is common in the western world. Due to the risk of undetected underlying colorectal cancer, most guidelines recommend a follow-up colonoscopy after an episode of diverticulitis. With the increased accuracy of computer tomography scans, there is an increased challenge to these guidelines in cases of uncomplicated diverticulitis. The aim of this study was to investigate the compliance to the recommended follow-up colonoscopies and to report the incidence of detection of advanced neoplasms.
Methods
In this single-center retrospective cohort study, all patients > 18 years that were admitted to the Hospital Center Biel with an episode of acute uncomplicated diverticulitis between 01.01.2013 and 31.12.2017 were identified. The incidence of advanced neoplasia was calculated by analyzing the follow-up colonoscopies performed and reviewing the histological findings.
Results
257 Patients with uncomplicated diverticulitis were included in this study. The mean age of the patients was 63 (range 22–96) years, and 54.5% were female. In 197 (77%) patients we recommended a follow-up colonoscopy. However, only 144 (73%) of these patients underwent the procedure. In the histological analysis, 2 (1.2%) carcinomas, one high-grade adenoma (0.6%) and 20 low-grade adenomas (12%) were detected.
Conclusion
The compliance to the recommendation of follow-up colonoscopies after uncomplicated diverticulitis is poor and has to be improved. A follow-up colonoscopy has its justification because of relevant findings in almost 14% of patients, more so in patients above screening age with 20% pathological findings, including 2 (5%) carcinomas.
Production of an interleukin-10 blocking antibody by genetically engineered macrophages increases cancer cell death in human gastrointestinal tumor slice cultures
Authors: Pillarisetty Venu , Labadie Kevin , Kreuser Shannon , Brempelis Katherine , Daniel Sara , Jiang Xiuyun , Sullivan Kevin , Utria Alan , Kenerson Heidi , Kim Teresa , Crane Courtney 
Published: November 2022

Abstract
Although it can promote effector T cell function, the summative effect of interleukin-10 (IL-10) in the tumor microenvironment (TME) appears to be suppressive; therefore, blocking this critical regulatory cytokine has therapeutic potential to enhance antitumor immune function. As macrophages efficiently localize to the TME, we hypothesized that they could be used as a delivery vehicle for drugs designed to block this pathway. To test our hypothesis, we created and evaluated genetically engineered macrophages (GEMs) that produce an IL-10-blocking antibody (aIL-10). Healthy donor human peripheral blood mononuclear cells were differentiated and transduced with a novel lentivirus (LV) encoding BT-063, a humanized aIL-10 antibody. The efficacy of aIL-10 GEMs was assessed in human gastrointestinal tumor slice culture models developed from resected specimens of pancreatic ductal adenocarcinoma primary tumors and colorectal cancer liver metastases. LV transduction led to sustained production of BT-063 by aIL-10 GEMs for at least 21 days. Transduction did not alter GEM phenotype as evaluated by flow cytometry, but ⍺IL-10 GEMs produced measurable quantities of BT-063 in the TME that was associated with an approximately 5-fold higher rate of tumor cell apoptosis than control.
Checking Reachability Property in Complex Concurrent Software Systems with a Knowledge Discovery Approach
Authors: partabian jaafar , Rafe Vahid 
Published: November 2022

Abstract
The model checking technique is a formal and effectual way in verification of software systems. By generation and verification of all model states, it analyses the software systems. The main issue in the model checking of the complicated systems having wide or infinite state space is the lack of memory in generation of all states which is referred to as "state space explosion". The Random Forest algorithm which is capable of knowledge discovery faces the above-cited problem by selecting a few promising paths. In our suggested method, first a small model of the system is developed by the formal language of graph transformation system (GTS). A training data set is created from the small state space. The generated training data set is made available to the Random Forest algorithm to detect and discover the logical relationships existent in it. Then, the knowledge acquired in this way is used in the smart and incomplete exploration of the large state space. The proposed approach is run in GROOVE which is an open source tool for designing and studying the model of graph transformation systems. The results indicate that the suggested method in accordance with the two criteria (average running time and the number of explored states) performs better compared with the other approaches.
What Patients Find on the Internet When Looking for Information About Percutaneous Coronary Intervention: Multilanguage Cross-sectional Assessment
Authors: Șulea Cristina M , Nădășan Valentin , Ursachi Tatiana , Toboltoc Paul-Cătălin , Benedek Theodora 
Published: November 2022

Background
The internet provides general users with wide access to medical information. However, regulating and controlling the quality and reliability of the considerable volume of available data is challenging, thus generating concerns about the consequences of inaccurate health care–related documentation. Several tools have been proposed to increase the transparency and overall trustworthiness of medical information present on the web.

Objective
We aimed to analyze and compare the quality and reliability of information about percutaneous coronary intervention on English, German, Hungarian, Romanian, and Russian language websites.

Methods
Following a rigorous protocol, 125 websites were selected, 25 for each language sub-sample. The websites were assessed concerning their general characteristics, compliance with a set of eEurope 2002 credibility criteria, and quality of the informational content (namely completeness and accuracy), based on a topic-specific benchmark. Completeness and accuracy were graded independently by 2 evaluators. Scores were reported on a scale from 0 to 10. The 5 language subsamples were compared regarding credibility, completeness, and accuracy. Correlations between credibility scores on the one hand, and completeness and accuracy scores, on the other hand, were tested within each language subsample.

Results
The websites’ compliance with credibility criteria was average at best with scores between 3.0 and 6.0. In terms of completeness and accuracy, the website subsets qualified as poor or average, with scores ranging from 2.4 to 4.6 and 3.6 to 5.3, respectively. English language websites scored significantly higher in all 3 aspects, followed by German and Hungarian language websites. Only German language websites showed a significant correlation between credibility and information quality.

Conclusions
The quality of websites in English, German, Hungarian, Romanian, and Russian languages about percutaneous coronary intervention was rather inadequate and may raise concerns regarding their impact on informed decision-making. Using credibility criteria as indicators of information quality may not be warranted, as credibility scores were only exceptionally correlated with content quality. The study brings valuable descriptive data on the quality of web-based information regarding percutaneous coronary intervention in multiple languages and raises awareness about the need for responsible use of health-related web resources.
Estrés, malestar psicológico, bienestar psicológico y satisfacción con la vida según modalidades de trabajo en madres de familia
Authors: Valle Pico Mariela Isabel , Larzabal Fernández Aitor 
Published: November 2022

La investigación tuvo como propósito comparar estrés, malestar psicológico, bienestar psicológico y satisfacción con la vida según las modalidades de trabajo en madres de familia. Se realizó un estudio descriptivo y comparativo, con diseño no experimental, enfoque cuantitativo y de corte transversal. Las participantes fueron 436 madres ecuatorianas, divididas en tres grupos: trabajo presencial, teletrabajo y trabajo no remunerado. El análisis estadístico ANOVA indicó diferencias significativas en las variables de malestar psicológico (F = 4.67; p < .01), bienestar psicológico (F = 7.64; p < .001) y satisfacción con la vida (F = 8.69; p < .001), siendo el grupo de trabajo no remunerado el que muestra mayores niveles de malestar psicológico y menores niveles en bienestar y satisfacción, y el teletrabajo con mejores puntuaciones en bienestar y satisfacción y bajos niveles en malestar psicológico. Se encontró en el estrés diferencias entre los grupos (F = 5.13; p = .02) al analizarlo con la covariable seguimiento educativo a través del ANCOVA. El grupo de trabajo no remunerado presentó niveles más altos en estrés al aumentar las horas de seguimiento educativo. Se concluye que la modalidad de trabajo está relacionada con el malestar psicológico, bienestar psicológico y satisfacción con la vida. Los niveles de estrés varían en función de la modalidad y aumentan cuando se destina más horas de seguimiento educativo.
Analysis of guidelines concerning navigation safety
Authors: Liutko Sergei 
Published: November 2022

The problem of navigation safety in modern navigation has been widely studied in the scientific works by many authors. Description of the subject area ‒ the safety of ship navigation ‒ is characterized by different terms, such as “safety of seafaring”, “safety of shipping” or “navigation safety”. However, one can hardly come across a clear definition of the terms. Each author considers the safety of a vessel's navigation from his own point of view and interprets this term in a different way. The term “safety of navigation” does not have clear boundaries, nor a single definition. Using this term the authors mean a subject area or activities united by a single goal. There is defined the autonomous part of the term “security”. This term refracts depending on the subject area, which can be explained by variability
of the tools used to achieve a given level of security. A holistic description of the term “safety” in the maritime industry is of particular importance, which will eliminate discrepancies and help clarify the modern terms related to maritime safety. There have been analyzed scientific works, guidelines, standards on the problem of navigation safety and proposed a classification of the terminological apparatus. The search and development of new approaches and methods for preventing ship accidents in the course of operation are becoming increasingly important. At present, the concept of safety in water transport has not been formed and systematized sufficiently, despite the excessive amount of research works devoted to this subject. The relationship between the concepts of “safety of navigation”, “safety of seafaring” or “safety of shipping” is considered. The idea of the concepts classification is proposed.
APENDICITE AGUDA: REVISÃO DE LITERATURA
Authors: Gutierrez Daiana , Hallam Beatriz , Pinheiro Fernanda , Rabello Rafaela , Damasceno de Oliveira Laira Lúcia 
Published: November 2022

A apendicite aguda é uma patologia caracterizada pela inflamação no apêndice, tratando-se de um quadro muito frequente quando há uma obstrução na luz apendicular, geralmente causada por fecálito (material fecal endurecido), hiperplasia linfoide e infecções parasitárias. O diagnóstico para apendicite aguda é clínico e o tratamento é realizado a partir da cirurgia para a retirada do apêndice, denominada apendicectomia. A principal complicação que pode ocorrer, caso o tratamento seja tardio, é a ruptura da parede do apêndice, fazendo com que haja um extravasamento de fezes e/ou pus na cavidade peritoneal, podendo resultar em formação de abscesso, sepse e óbito. O objetivo deste estudo foi avaliar e sintetizar os resultados obtidos a partir de um levantamento bibliográfico sobre essa patologia. Para isso, foram revisados diversos artigos científicos sobre o tema, sendo obtidos como resultados a definição de apendicite aguda, que afeta indivíduos de qualquer faixa etária e gênero, contudo, tem predominância entre adultos jovens, além de formas de diagnóstico, sendo estes por imagem, clínico e por meio de exames. Foi concluído que a apendicite aguda é uma patologia muito comum, seu diagnóstico é principalmente clínico e seu tratamento é por meio da “apendicectomia”, tanto o diagnóstico quanto o tratamento devem ser realizados precocemente visando evitar complicações.
Effect of Stem Cell Therapy on Patients’ Quality of Life in Heart Failure with Reduced Ejection Fraction
Authors: Mostafavian Zahra ,   Department of Community Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran, Vakilian Farveh ,   Cardiothoracic Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,   Farveh Vakilian, Cardiologist, Fellowship in Heart Failure, Cardiothoracic Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, E-mail: vakilianf@mums.ac.ir, Torkmanzade Leila ,   Faculty of Medicine, Islamic Azad University, Mashhad Branch, Mashhad, Iran, Moghiman Toktam ,   Mashhad University of Medical Sciences, Mashhad, Iran
Published: November 2022

Introduction
Heart failure with reduced ejection fraction (HFrEF) is a debilitating disease in which Left Ventricular Ejection Fraction (LVEF) is ≤ 40%, and it involves various organs. Regarding the novelty of stem cell therapy in HF, we aimed at studying the effect of stem cell therapy on the QoL of patients with HFrEF.

Materials and Methods
In a prospective study, 30 patients diagnosed with HFrEF who had undergone stem cell injection (study group) and 30 patients with HFrEF receiving guideline-directed medical therapy (control group) were recruited by convenience sampling during 2016 in Mashhad, Iran. Patients’ quality of life, left ventricular ejection fraction and their disability degree were studied twice with a 3-month interval. For data analysis, paired t-test, chi2 and multivariate linear regression were used.

Results
The mean age of study and control groups was 61.3±10.24 and 60.93±7.88 years respectively. Ninety percent of the cases and 56.7% of the controls were male (P=0.003). A significant difference in QoL was observed before and after treatment in each group (P<0.05). However, the QoL score showed no statistical difference between the two groups following treatment (P=0.13). The same result was achieved for LVEF (P=0.18); whereas the NYHA function class showed a significant difference between the two groups following treatment (P=0.017).

Conclusions
According to the results, it seems that the treatment of HFrEF patients with stem cells is as effective as conventional therapies in improving the LVEF and QoL and more efficient than conventional treatments in increasing the patients’ general satisfaction with life.