bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and accurate identification of Pantoea dispersa with a case of spontaneous rupture of hepatocellular carcinoma in China
Authors: Yang Yang , Hu Haitao , Zhou Chenglin , Zhang Wenyun , Yu Yang , Liu Qingyi , Lu Taohong , Zhang Qingfang 
Published: January 2022

Abstract

Introduction:

Pantoea dispersa belongs to the genus Pantoea, which is isolated from Enterobacteriaceae. It has been reported to cause some kinds of infections, but there are few detailed studies on it, especially its characteristics and identification methods, which has caused a lot of trouble in clinical work.

Patient concerns:
A 51-year-old Chinese man was admitted to our hospital with a 7-hour history of progressive abdominal pain. He was previously diagnosed with liver cirrhosis secondary to chronic hepatitis B infection and hepatocellular carcinoma. An emergency hepatic artery embolization for hemostasis was performed under local anesthesia. Forty-eight hours later, the patient presented sudden onset of high fever up to 39.0 °C and chill.

Diagnosis:
Morphological and phenotypic profiles were performed for preliminary identification for P dispersa. The biochemical features were obtained by VITEK 2 Test Kit. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis and 16S ribosomal RNA sequencing were performed to accurately identify P dispersa.

Intervention:
Antibiotic therapy of intravenous ceftazidime was started empirically. The antibiotic treatment was switched to intravenous cefepime at the same time because of suspected ceftazidime treatment failure and microbiological sensitivity.

Outcomes:
The patient remained afebrile, and the second blood culture results were negative. Chest X-ray was normal as well. In order to control the progression of the hepatic lesion, transarterial chemoembolization was performed under local anesthesia. After completion of 14 days of antibiotic treatment, the patient was discharged with no signs of recurrence.

Conclusion:

P dispersa, a gram-negative bacterium rod, were facultative anaerobic, which displayed yellow pigmentation, round, raised, smooth on culture plates. Conventional analysis was difficult to complete its identification. With biochemical tests, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis and 16S ribosomal RNA sequencing, P dispersa can be accurately identified. It will help physicians understand the related clinical manifestations and make timely and effective treatment for patients.
Detection of traumatic internal carotid artery pseudoaneurysm by postmortem imaging
Authors: Wan Lei , Song Yanxiang , Li Zhengdong , Wang Maowen , Song Fengxiang , Zhang Jianhua , Zou Donghua , Liu Ningguo , Shi Yuxin , Zhang Zhiyong 
Published: January 2022

Abstract

Rationale:
Postmortem imaging (PMI), including computed tomography (PMCT), postmortem computed tomography angiography (PMCTA), and postmortem magnetic resonance imaging (PMMRI), is rapidly becoming effective and a practical method in forensic medicine. This study aimed to present a specific forensic case in which the PMI approach and its applications were used.

Patient concerns:
A 40-year-old male patient had moderate unilateral nose bleeding constantly 10 times after suffering from a head injury induced by a car accident. After a bilateral massive nose bleeding for the last time, he died from hemorrhagic shock. Traumatic internal carotid artery pseudoaneurysm (TICAP) was suspected in this patient.

Diagnosis, interventions, and outcomes:
A whole-body scanning was performed using PMCT and PMMRI. Then, PMCTA using left ventricular cardiac puncture was also implemented. A water-soluble contrast agent was injected into the left ventricle and pumped toward the intracranial, followed by a repeated whole-body PMCT scan. The PMCT/PMMRI detected a high-density/signal mass inside the left sphenoid sinus. The PMCTA detected a distinct leakage of the contrast agent into the left sphenoid sinus from an adjacent aneurysm of the C3 section of the left internal carotid artery. Autopsy and histology confirmed a TICAP inside the sphenoid sinus.

Lessons:
This case showed that the PMI was of great value for identifying the cause of death in special cases. When vascular lesions are suspected in the body, PMI and especially the PMCTA approach may be an effective detection method.
Effectiveness and safety of acupuncture for chronic obstructive pulmonary disease
Authors: You Tian-Yi , Zhang Hao-Yang , Li Ji-Quan , Ma Tie-Ming 
Published: January 2022

Abstract

Background:
Chronic Obstructive Pulmonary Disease (COPD) is the most common respiratory disease in clinic. Traditional Chinese medicine (TCM) lung rehabilitation has gradually been valued in the field of prevention and treatment of COPD. Acupuncture, as an important part of TCM lung rehabilitation, is carried out in clinical extensively and application. It has the advantage of improving the symptoms and quality of life of COPD cases, but the evidence-based proof is limited.

Methods:
Eight databases will be systematically retrieved from their inceptions to December 2021. This study will include randomized controlled trials of acupuncture in the treatment of COPD with stable stage. The main outcome will include clinical effective rate, TCM symptom score, quality of life, dyspnea, exercise capacity, lung function, frequency of acute exacerbation, adverse events. Literature screening, quality evaluation and information extraction will be completed by two independent researchers. Revman 5.3 software will be used to perform meta-analysis. Assessment of multiple systematic reviews-2 tool will be used for evaluating the methodological quality of systematic review (SR), grading of recommendations assessment will for rating the quality of evidence, and consolidated standards of reporting trials and Standards for Reporting Interventions in Clinical Trials of Acupuncture tool will for assessing the reporting quality of randomized controlled trials.

Results:
The findings of this SR will be presented at relevant conferences and submitted for peer-review publication.

Conclusions:
The findings of this SR will provide up-to-date summary proof for evaluating the effectiveness and safety of acupuncture for COPD.
PD-1 inhibitor toripalimab with gemcitabine as a neoadjuvant therapy for muscle-invasive bladder urothelial carcinoma
Authors: Yin Huaqi , Yongkang Ma , Bao Guan , Shiming Zhao , Chaohong He , Tiejun Yang 
Published: January 2022

Abstract

Rationale:
Routine neoadjuvant therapy for muscle-invasive bladder urothelial carcinoma prior to radical surgery is curative. With the increase in cancer immunotherapy, neoadjuvant immunotherapy has been used as an important complement to neoadjuvant chemotherapy for muscle-invasive urothelial carcinoma. Toripalimab is a recombinant, humanized IgG4 monoclonal antibody directed against programmed cell death protein 1 and received the first global approval for the treatment of unresectable or metastatic melanoma in China on December 17, 2018.

Patient concerns and diagnosis:
A 57-year-old man was admitted to our hospital because of hematuria for 1 week. The patient was diagnosed pathologically with muscle-invasive bladder urothelial carcinoma.

Interventions and outcomes:
The patient received neoadjuvant toripalimab combined with gemcitabine therapy. The patient showed partial response. Subsequently, radical cystectomy was performed.

Lessons:
Toripalimab combined with gemcitabine exhibited accurate antitumor activity and may be a promising novel neoadjuvant therapy for muscle-invasive urothelial carcinoma.
Traditional Chinese medicine Jianpi therapy in exercise-induced fatigue
Authors: Geng Xue , Guo Xiujuan , Liu Baoquan , Yu Peiying , Li Jiazhou , Pan Huashan 
Published: January 2022

Abstract

Background:
Exercise-induced fatigue (EIF) is a common occurrence in sports competition and training. It may cause trouble to athletes’ motor skill execution and cognition. Although traditional Chinese medicine Jianpi therapy has been commonly used for EIF management, relevant evidence on the effectiveness and safety of Jianpi therapy is still unclear.

Methods:
Databases including PubMed, Embase, Web of Science, the Cochrane Library, SinoMed, China Science and Technology Journal Database (VIP), China National Knowledge Infrastructure (CNKI), and Wanfang will be searched for relevant randomized controlled trials from databases from 2000 to 2021. Randomized controlled trials related to traditional Chinese medicine Jianpi therapy in the treatment and management of EIF will be included. Systematic review and meta-analysis of the data will be performed in RevMan 5.3 according to the Preferred Reporting Items of Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Two authors independently performed the literature searching, data extraction, and quality evaluation. Risk of bias was assessed using the Cochrane Risk of Bias Tool for randomized clinical trials.

Results:
This systematic review and meta-analysis will summarize the latest evidence for traditional Chinese medicine Jianpi therapy in EIF. The results will be submitted to a peer-reviewed journal once completed.

Conclusion:
The conclusion of our research will provide evidence to support traditional Chinese medicine Jianpi therapy as an effective intervention for patients with EIF.
OSF Registration DOI: 10.17605/OSF.IO/NRKX4.
Acute myeloid leukemia in a farmer with long term exposure to pesticides in Korea
Authors: Jeon Ye-eun , Ha Jea Chul , Kim Seonggyu , Heo Mi Hwa , Do Young Rok , Chung Insung 
Published: January 2022

Abstract

Rationale:
Pesticides are chemical substances used to kill harmful insects, small animals, wild plants, and other unwanted organisms. It has not been clearly demonstrated in myeloid malignancies, particularly acute myeloid leukemia.

Patient concerns:
A 46-year-old male farmer visited the hospital with chief complaints of multiple purpuric macules on the left upper chest to both leg areas. The patient had been farming lotus roots for 20 years and was exposed to a substantial amount of pesticide without proper personal protective equipment.

Diagnoses:
The patient was diagnosed with acute myeloid leukemia by bone marrow biopsy.

Intervention:
The patient received induction chemotherapy with idarubicin and cytarabine. He has undergone consolidation chemotherapy two more times.

Outcomes:
He had neutropenic fever as a complication after chemotherapy, but he is doing well with no other symptoms. There has been no abnormality in blood tests since the consolidation therapy, and it has been well maintained in remission.

Conclusion:
This case report suggests that acute myeloid leukemia is associated with occupational pesticide exposure, along with a review of the literature. The impact of occupational pesticide exposure on myeloid leukemia has not been clearly established, and large-scale studies on the relationship between pesticide use and cancer, including myeloid leukemia, should be conducted.
The Transforming Outcomes for Patients Through Medical Home Evaluation and reDesign (TOPMED) Cluster Randomized Controlled Trial
Authors: Colasurdo Joshua , Pizzimenti Christie , Singh Sumeet , Ramsey Katrina , Ross Rachel , Sachdeva Bhavaya , Dorr David A. 
Published: January 2022

Background:
Primary Care Medical Home (PCMH) redesign efforts are intended to enhance primary care’s ability to improve population health and well-being. PCMH transformation that is focused on “high-value elements” (HVEs) for cost and utilization may improve effectiveness.

Objectives:
The objective of this study was to determine if a focus on achieving HVEs extracted from successful primary care transformation models would reduce cost and utilization as compared with a focus on achieving PCMH quality improvement goals.

Research Design:
A stratified, cluster randomized controlled trial with 2 arms. All practices received equal financial incentives, health information technology support, and in-person practice facilitation. Analyses consisted of multivariable modeling, adjusting for the cluster, with difference-in-difference results.

Subjects:
Eight primary care clinics that were engaged in PCMH reform.

Measures:
We examined: (1) total claims payments; (2) emergency department (ED) visits; and (3) hospitalizations among patients during baseline and intervention years.

Results:
In total, 16,099 patients met the inclusion criteria. Intervention clinics had significantly lower baseline ED visits (P=0.02) and claims paid (P=0.01). Difference-in-difference showed a decrease in ED visits greater in control than intervention (ED per 1000 patients: +56; 95% confidence interval: +96, +15) with a trend towards decreased hospitalizations in intervention (−15; 95% confidence interval: −52, +21). Costs were not different. In modeling monthly outcome means, the generalized linear mixed model showed significant differences for hospitalizations during the intervention year (P=0.03).

Discussion:
The trial had a trend of decreasing hospitalizations, increased ED visits, and no change in costs in the HVE versus quality improvement arms.
The 2018 Merit-based Incentive Payment System
Authors: Gettel Cameron J. , Han Christopher R. , Canavan Maureen E. , Bernheim Susannah M. , Drye Elizabeth E. , Duseja Reena , Venkatesh Arjun K. 
Published: January 2022

Background:
The Merit-based Incentive Payment System (MIPS) incorporates financial incentives and penalties intended to drive clinicians towards value-based purchasing, including alternative payment models (APMs). Newly available Medicare-approved qualified clinical data registries (QCDRs) offer specialty-specific quality measures for clinician reporting, yet their impact on clinician performance and payment adjustments remains unknown.

Objectives:
We sought to characterize clinician participation, performance, and payment adjustments in the MIPS program across specialties, with a focus on clinician use of QCDRs.

Research Design:
We performed a cross-sectional analysis of the 2018 MIPS program.

Results:
During the 2018 performance year, 558,296 clinicians participated in the MIPS program across the 35 specialties assessed. Clinicians reporting as individuals had lower overall MIPS performance scores (median [interquartile range (IQR)], 80.0 [39.4–98.4] points) than those reporting as groups (median [IQR], 96.3 [76.9–100.0] points), who in turn had lower adjustments than clinicians reporting within MIPS APMs (median [IQR], 100.0 [100.0–100.0] points) (P<0.001). Clinicians reporting as individuals had lower payment adjustments (median [IQR], +0.7% [0.1%–1.6%]) than those reporting as groups (median [IQR], +1.5% [0.6%–1.7%]), who in turn had lower adjustments than clinicians reporting within MIPS APMs (median [IQR], +1.7% [1.7%–1.7%]) (P<0.001). Within a subpopulation of 202,685 clinicians across 12 specialties commonly using QCDRs, clinicians had overall MIPS performance scores and payment adjustments that were significantly greater if reporting at least 1 QCDR measure compared with those not reporting any QCDR measures.

Conclusions:
Collectively, these findings highlight that performance score and payment adjustments varied by reporting affiliation and QCDR use in the 2018 MIPS.
Humoral and T-cell immune response after three doses of mRNA SARS-CoV-2 vaccines in fragile patients: the Italian VAX4FRAIL study
Authors: Corradini Paolo , Agrati Chiara , Apolone Giovanni , Mantovani Alberto , Giannarelli Diana , Marasco Vincenzo , Bordoni Veronica , Sacchi Alessandra , Matusali Giulia , Salvarani Carlo , Zinzani Pier Luigi , Mantegazza Renato , Tagliavini Fabrizio , Lupo-Stanghellini Maria Teresa , Ciceri Fabio , Damian Silvia , Uccelli Antonio , Fenoglio Daniela , Silvestris Nicola , Baldanti Fausto , Piaggio Giulia , Ciliberto Gennaro , Morrone Aldo , Locatelli Franco , Sinno Valentina , Rescigno Maria , Costantini Massimo 
Published: January 2022

AbstractBackgroundPatients with solid or hematological tumors, neurological and immune-inflammatory disorders represent potentially fragile subjects with increased risk to experience severe COVID-19 and inadequate response to SARS-CoV2 vaccination.MethodsWe designed a prospective Italian multicentric study to assess humoral and T-cell response to SARS-CoV2 vaccination in patients (n=378) with solid tumors (ST), hematological malignancies (HM), neurological (ND) and immuno-rheumatological diseases (ID). The immunogenicity of primary vaccination schedule and of the booster dose were analyzed.ResultsOverall, patient seroconversion rate after two doses was 62.1%. A significant lower rate was observed in HM (52.4%) and ID (51.9%) patients compared to ST (95.6%) and ND (70.7%); a lower median level of antibodies was detected in HM and ID versus the others (p<0.0001). A similar rate of patients with a positive SARS-CoV2 T-cell response was observed in all disease groups, with a higher level observed in the ND group. The booster dose improved humoral responses in all disease groups, although with a lower response in HM patients, while the T-cell response increased similarly in all groups. In the multivariable logistic model, the independent predictors for seroconversion were disease subgroups, type of therapies and age. Notably, the ongoing treatment known to affect the immune system was associated with the worst humoral response to vaccination (p<0.0001), but had no effects on the T-cell responses.ConclusionsImmunosuppressive treatment more than disease typeper seis a risk factor for low humoral response after vaccination. The booster dose can improve both humoral and T-cell response.Article’s main point-Lower rate of seroconversion was observed in fragile patients as compared to healthy controls-The booster dose improves humoral and T-cell response in all fragile patient groups-Immunosuppressive treatment was associated with the worst humoral response to vaccination, but had no effects on T-cell responses.
Rat Leukocyte Population Dynamics Predicts a Window for Intervention in Aging
Authors: Yanai Hagai , Dunn Christopher , Park Bongsoo , Coletta Christopher , McDevitt Ross A. , McNeely Taylor , Leone Michael , Wersto Robert P. , Perdue Kathy A. , Beerman Isabel 
Published: January 2022

AbstractAge-associated changes in human hematopoiesis have been mostly recapitulated in mouse models; but not much has been explored in rats, a physiologically closer model to humans. To establish whether rat hematopoiesis closely mirrors humans’, we examined the peripheral blood of rats throughout their lifespan. Significant age-associated changes showed distinctive population shifts predictive of age. A divergence between predicted versus chronological age changes was indicative of fragility; thus, these data may be a valuable tool to identify underlying diseases or as a surrogate predictor for intervention efficacy. Notably, several blood parameters and DNA methylation alterations defined specific leverage points during aging, supporting non-linear aging effects and highlighting a roadmap for interventions at these junctures. Overall, we present a simple set of rat blood metrics that can provide a window into their health and inform the implementation of interventions in a model system physiologically relevant for humans.
ACDC: Analysis of Congruent Diversification Classes
Authors: Höhna Sebastian , Kopperud Bjørn T. , Magee Andrew F. 
Published: January 2022

Summary1. Diversification rates inferred from phylogenies are not identifiable. There are infinitely many combinations of speciation and extinction rate functions that have the exact same likelihood score for a given phylogeny, building a congruence class. The specific shape and characteristics of such congruence classes have not yet been studied. Whether speciation and extinction rate functions within a congruence class share common features is also not known.2. Instead of striving to make the diversification rates identifiable, we can embrace their inherent non-identifiable nature. We use two different approaches to explore a congruence class: (i) testing of specific alternative hypotheses, and (ii) randomly sampling alternative rate function within the congruence class.3. Our methods are implemented in the open-source R package ACDC (https://github.com/afmagee/ACDC). ACDC provides a flexible approach to explore the congruence class and provides summaries of rate functions within a congruence class. The summaries can highlight common trends, i.e. increasing, flat or decreasing rates.Although there are infinitely many equally likely diversification rate functions, these can share common features. ACDC can be used to assess if diversification rate patterns are robust despite non-identifiability. In our example, we clearly identify three phases of diversification rate changes that are common among all models in the congruence class. Thus, congruence classes are not necessarily a problem for studying historical patterns of biodiversity from phylogenies.
Government and innovation performance: evidence from the ICT enterprising community
Authors: Murati-Leka Herolinda , Fetai Besnik 
Published: January 2022

Purpose
The purpose of this paper will be on finding and analyzing the impact of government on the information and communication technology (ICT) companies’ innovation performance. The study aims to conduct in-depth research about the government as an integrated actor of the innovation ecosystem (IE), not a sole member. This would be the core finding toward doing further research about the impact of the innovation ecosystem in the ICT sector in Kosovo.

Design/methodology/approach
Quantitative research has been considered the most suitable data collection method. Furthermore, in this study, it is used convenience sampling as a technique of the sampling process. The sample size of this study is 106 participants. The participants are owners or representatives of ICT companies in Kosovo. Since the study is conducted using the deductive approach, the questionnaire is considered to be the most suitable instrument for gathering data.

Findings
This paper provides empirical insights that the company’s size and the dedicated department for research and development have no impact on how the company takes advantage of public funding from the government. Furthermore, the authors of the paper found out that government has a positive impact on companies’ introduction of new products and services, while the impact of the government on a company’s financial performance was insignificant.

Research limitations/implications
The future research direction should be firstly on studying other IE actors and their impact on companies’ innovation performance and secondly on measuring the IE actors as a set of actors to have a broader picture on how IE impacts the companies’ innovation performance.

Practical implications
The scientific contribution of this study will be on mapping, analyzing and proposing government policies in accordance with the findings of this study that would lead to a more comprehensive and sustainable IE in Kosovo.

Originality/value
This study tries to fulfill an identified need to study the impact of interconnected actors of an innovation ecosystem and to show how they affect each other. In this study, it is taken for research one fragment of a set of actors.