bluuebunny/crossref_metadata_2025_split huggingface dataset:
The OptimaMed intervention to reduce medication burden in nursing home residents with severe dementia: Results from a pragmatic, controlled study
Authors: Kröger Edeltraut , Wilchesky Machelle , Morin Michèle , Carmichael Pierre-Hugues , Marcotte Martine , Misson Lucie , Plante Jonathan , Voyer Philippe , Durand Pierre 
Published: November 2022

Abstract
Background: Nursing home (NH) residents with severe dementia use many medications, sometimes inappropriately within a comfort care approach. Medications should be regularly reviewed and eventually deprescribed. This pragmatic, controlled trial assessed the effect of an interprofessional knowledge exchange (KE) intervention to decrease medication load and the use of medications of questionable benefit among these residents.
Methods: A 6-month intervention was performed in 4 NHs in the Quebec City area, while 3 NHs, with comparable admissions criteria, served as controls. Published lists of “mostly”, “sometimes” or “exceptionally” appropriate medications, tailored for NH residents with severe dementia, were used. The intervention included 1) information for participants’ families about medication use in severe dementia; 2) a 90-minute KE session for NH nurses, pharmacists, and physicians; 3) medication reviews by NH pharmacists using the lists; 4) discussions on recommended changes with nurses and physicians. Participants’ levels of agitation and pain were evaluated using validated scales at baseline and follow-up.
Results: Seven (7) NHs and 123 participants were included for study. The mean number of regular medications per participant decreased from 7.1 to 6.6 in the intervention, and from 7.7 to 5.9 in the control NHs (p-value for the difference in differences test: < 0.05). Levels of agitation decreased by 8.3% in the intervention, and by 1.4% in the control NHs (p=0.026); pain levels decreased by 12.6% in the intervention and increased by 7% in the control NHs (p=0.049). Proportions of participants receiving regular medications deemed only exceptionally appropriate decreased from 19% to 17% (p=0.43) in the intervention and from 28% to 21% (p=0.007) in the control NHs (p=0.22). The mean numbers of regular daily antipsychotics per participant fell from 0.64 to 0.58 in the intervention and from 0.39 to 0.30 in the control NHs (p=0.27).
Conclusions: This interprofessional intervention to reduce inappropriate medication use in NH residents with severe dementia decreased medication load in both intervention and control NHs, without important concomitant increase in agitation, but mixed effects on pain levels. Practice changes and heterogeneity within these 7 NHs, and a ceiling effect in medication optimization likely interfered with the intervention.
The study is registered at ClinicalTrials.gov : # NCT05155748 (first registration 14-12-2021)
Effect of ambient factors over spinel CuMn2O4 for toluene catalytic ozonation: Enhancement of the synergy and the generation of ROS
Authors: Wang Guanjie , Zhao Bo , Ye Zhiping , Zhao Liang , Zhang Xiuwen , Wang Jiade 
Published: November 2022

Abstract
Herein, the effect of ambient factors (O3 concentration, temperature, and humidity) was explored in catalytic ozonation of toluene by using CuMn2O4, which possessed a great steady-state activity (~ 73%) at the optimal conditions (2100 ppm O3, 100℃, and dry air). Under various conditions, a strong correlation was observed between O3 consumption, toluene oxidation, and COx formation. The technology of DRIFTS and GC-MS were used to study the effects of influencing factors on the toluene degradation process. Cu+ plays an important role in the adsorption of toluene and the oxidation of toluene to benzoic acid. The ·OH and temperature suppressed the deposition of carbonaceous by-products. On the other hand, the situation of the effect of influence factors was investigated by SEM, BET, XPS, and TG. It is revealed that reactive oxygen species are the key to catalytic ozonation and participate in catalytic oxidation of toluene as an electron transfer intermediate on active sites (Cux+-Ov-Mny+).
Effect of agricultural fiscal incentives on agricultural carbon intensity in China
Authors: Zhang Zhuang , Chen You-Hua , Tian Yun 
Published: November 2022

Abstract
Few studies provide direct evidence that agricultural fiscal affects agricultural carbon intensity, we try to fill this gap. Using panel data of 30 provinces in China from 2005 to 2019, we conclude that agricultural fiscal expenditures significantly reduce agricultural carbon intensity. The result is still robust after employing the provincial agricultural leaders’ birthplace information as an instrumental variable. Further study shows that the negative effect of agricultural fiscal expenditures on agricultural carbon intensity is more pronounced in regions with less corruption, and is also more visible in central, western and inland regions than other areas. For this effect, agricultural technological improvement and structure optimization are possible channels, but not operation scale expansion. Interestingly, although agricultural fiscal expenditures reduce the local agricultural carbon intensity, other regions' carbon intensity is increased due to fiscal rivalry.
HSP90 is a potential risk factor for ovarian cancer prognosis: an evidence of a Chinese clinical center
Authors: Duan Cancan , Li Kuokuo , Wei Zhaolian , Pan Xiaohua , Xiao Lan 
Published: November 2022

Abstract
Background: The potential treatment effects of heat shock protein90 (HSP90) inhibitors in ovarian cancer (OC) are controversial. This research aims to investigate the relationship between the expression level of HSP90 in peripheral blood and the prognosis of OC patients, as well as the clinicopathological indicators related to prognosis.
Materials and Methods: We retrospectively analysed the clinicopathological indicators of OC patients who were admitted to the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Anhui Medical University from 2017 to 2022. HSP90 expression in patient blood was detected by enzyme-linked immunosorbent assay, and the correlation between HSP90 expression and OC prognosis was systematically investigated. Kaplan-meier methodwas used to draw the survival curve, and the average survival time and survival rate were calculated. The log-rank test and Cox model were used for univariate survival analysis, and the Cox proportional hazards model was applied for multivariate survival analysis. Based on the TCGA dataset of OC obtained by Cbioportal, Pearson’s correlation coefficients between HSP90 expression values and other mRNA expression values were calculated to conduct bioinformatics analysis.
Results: According to the established screening criteria, 106 patients were selected as subjects. The enzyme-linked immunosorbent assay results showed that HSP90 was 50.94% overexpressed in patients with OC. According to the outcome of Kaplan–Meier curves, the results revealed that the high level ofHSP90 expression was suggested to poor prognosis (P = 0.000) of OC patients. Further more, the result of multivariate Cox proportional hazards regression model analysis also predicted that high HSP90 expression (HR = 3.498, 95% CI =1.431-8.551, P = 0.000) was leaded to poor prognosis,which could be an independent prognostic factor for the prognosis of OC patients. Moreover, 100 genes screened by Pearson’s value associated with HSP90, which is participate in regulating pathway of ATFS target genes, PRAGC1A target genes and BANP target genes and enriched in metabolic processesof cell response to DNA damage stimulus, response to heat and protein folding.
Conclusion: The overexpression of HSP90 is positively associated with OC mortality and is a potential prognostic indicator of OC.
The effect of Covid-19 pandemic lockdown on air pollutants levels within the Baghdad International Airport area in Iraq
Authors: Al-Mashhadani Sawsan , Al-Sharify Zainab , Kariem Nagam , Al-Moameri Harith , Al-Sharify Mushtaq Talib , Kaysi Nameer 
Published: November 2022

Abstract
Airports and the aviation industry cause regional and global environmental pollution due to their various activities. Therefore, improving the environmental performance has become a global challenge to giving high priority to environmental protection. This study measured and analyzed the essential air pollutants associated with aircraft movement in the Baghdad International Airport (BIA). Responsible for (77%) of the air traffic in Iraq, the largest and most important airport in Iraq, during the restart of the sector after stopping due to the Covid − 19 pandemic, and comparing them with local and global determinants, as well as comparing them with measurements made before the pandemic. The study dealt with selecting reference measurement sites recommended by the International Civil Aviation Organization (ICAO), where gases and particulates were measured in (12) external and internal sites, using advanced portable devices approved by the Iraqi Ministry of Health and Environment. Gases and molecular measurements were made for (45) flight operations, and (570) external and internal measurements were made, and concentrations of some parameters were recorded outside the permissible limits outside, such as: PM₁₀ = 215.8 µg/m3, TSP = 450.5 µg/m3, NO₂ = 3.01 ppm, SO2 = 0.76 ppm, O3 = 1.47 ppm, VOCS = 0.89 ppm, while internal measurements recorded the maximum concentrations at TSP = 21.2 µg/m3, NO₂ = 2.13 ppm, and O3 = 0.66 ppm. This calls for setting up fixed stations for continuous monitoring of air pollutants, conducting periodic checks and implementing the necessary treatments.
Endothelial cell-derived stem cell factor promotes lipogenesis through c-Kit-mediated upregulation of lipogenic enzymes in brown adipocytes
Authors: Koh Gou Young , Lee Hyuek Jong , Kim Young-Chan , Kim JungMo , Yang Myung Jin , Hong Seon Pyo , Lee Jueun , Hwang Geum-Sook 
Published: November 2022

Abstract
Thermogenic function of brown adipose tissue (BAT) has beneficial effects in metabolic diseases by utilizing lipids and glucose, whereas inactive BAT accumulates lipids in brown adipocytes (BAs), leading to BAT whitening. Although cellular crosstalk between endothelial cells (ECs) and adipocytes is important for fatty acid uptake in adipocytes, the roles of ECs in de novo lipogenesis (DNL) of adipocytes have been poorly understood. Using single-nucleus RNA sequencing and knock-out mice, we demonstrate that stem cell factor (SCF) from ECs promotes DNL by activating c-Kit in BAs. In the early phase of lipid accumulation induced by denervation or thermoneutrality, transiently expressed c-Kit on BAs upregulates DNL enzymes via PI3K and AKT signaling. EC-specific SCF deletion and BA-specific c-Kit deletion attenuate lipogenic enzymes and inhibit the enlargement of lipid droplets in BAs after denervation or thermoneutrality. These data provide insight into SCF/c-Kit signaling as a novel lipogenic regulator that promotes DNL in the early phase of lipid accumulation when thermogenesis is inhibited in BAT.
A unified platform for RNA-seq analysis in non-model species
Authors: Liu Peng , Ewald Jessica , Legrand Elena , Jeon Yeon-Seon , Sangiovanni Jonathan , Hacariz Orcun , Pang Zhiqiang , Zhou Guangyan , Head Jessica , Basu Niladri , Xia Jianguo 
Published: November 2022

Abstract
The increasing application of RNA-seq to study non-model organisms demands easy-to-use and efficient bioinformatics tools to help researchers quickly uncover biological and functional insights from large datasets. Here, we present a unified software suite for processing, analyzing, and interpreting RNA-seq data from any eukaryotic species. This suite consists of a) EcoOmicsDB (www.ecoomicsdb.ca), a database for ortholog mapping and cross-species comparison; b) EcoOmicsAnalyst (www.ecoomicsanalyst.ca), a platform for raw data processing and annotation; and c) ExpressAnalyst (www.expressanalyst.ca), a platform for statistical and functional analysis. The utilities of this suite are demonstrated through case studies of RNA-seq data from multiple non-model species with or without reference transcriptomes. By coupling ultra-fast read mapping algorithms with high-resolution ortholog databases through a user-friendly web interface, the tool suite enables researchers to obtain global expression profiles and gene-level insights from raw RNA-seq reads within 24 hours.
Clinical value of ultrasonic indicators in predicting the outcome of caesarean scar pregnancy after pregnancy termination
Authors: Fu Liye , Yuan Hongxia , Cao Hong , Zhou Qichang , Tan Xiaotan , Guo Jun 
Published: November 2022

Abstract
Objective: To investigate the predictive value of ultrasound indicators in early pregnancy for the outcome of caesarean scar pregnancy (CSP) after uterine clearance.
Methods: This study retrospectively analysed the ultrasound images of 98 patients with CSP who underwent uterine clearing during early pregnancy at Changsha Hospital for Maternal and Child Health Care, between January 2017 and October 2021. Patients were equally divided into a case group and a control group. The case group included 49 patients with CSP who had intraoperative blood loss ≥200 ml or retained products of conception (RPOC). The remaining 49 patients with CSP, with similar age and gestational age and no postoperative complications, were divided into the control group. Differences in ultrasound indicators between the case and control group were compared.
Results: There were significant differences between the case and the control group in the mean gestational sac diameter (MGSD), the thinnest muscle thickness between the gestational sac and the bladder, and the blood flow from the incision around the gestational sac (P< 0.05). Furthermore, the rs of each ultrasound indicator were as follows: 0.258, -0.485, 0.369. The receiver operating characteristic (ROC) curve analysis of the thinnest muscle thickness prediction of postoperative complications of the optimal threshold was 2.3 mm.
Conclusion: Thickness of the thinnest muscle and blood flow from the incision around the gestational sac have a low correlation with the postoperative complications of early pregnancy termination in patients with CSP, which can help predict the clinical outcome of patients with CSP.
Induction of tissue-specific premature stem cell aging via Lef1 deficiency promotes senescence-like deterioration in remote organs
Authors: Ikuno Yasuaki , Watanabe Koichiro , Kakeya Yumi , Ikeno Shinsuke , Nakabo Toshimasa , Narumoto Ayano , Kande Yukie , Hayashi Tomoki , Minami Kahori , Nobuhiro Kasumi , Mabuchi Yo , Nakamura Shiho , Okano Hideyuki , Ihara Dai , Katsuyama Yu , Naka-Kaneda Hayato 
Published: November 2022

Abstract
Molecular mechanisms of aging specific to each stem cell (SC) are being elucidated. However, the common molecular basis for senescence in various SCs remains largely unexplored. Here, we have shown that the dysregulation of DNA damage response (DDR) modulated by lymphoid enhancer-binding factor 1 (Lef1) and DDR-microRNAs (DDR-miRs) is the common molecular basis for aging in SCs. We identified Lef1as the most repressed transcription factor with aging in common between mesenchymal stem/stromal cells (MSCs) and hematopoietic stem/progenitor cells. Like the expression profiles of aged MSCs, Lef1 knockdown reduced broad microRNAs and loss of induction of DDR-miRs in young MSCs. DDR capacity was also diminished in aged SCs in vivo. Moreover, Lef1 deficiency in intestinal stem cells induced precocious dysregulation of DDR and inflammation and senescence in the remote brain. This study demonstrates that the Lef1/DDR-miR axis is the common molecular basis underlying SC aging.
Individuals with and without child maltreatment experiences are evaluated similarly and do not differ in facial affect display at zero-and first- acquaintance
Authors: Hautle Lara-Lynn , Kurath Jennifer , Jellestad Lena , Lüönd Antonia M. , Wingenbach Tanja S. H. , Frühholz Sascha , Jansson Billy , Niedtfeld Inga , Pfaltz Monique C. 
Published: November 2022

Abstract
Background
Individuals with child maltreatment (CM) experiences are more often disliked, rejected and victimized compared to individuals without such experiences. However, contributing factors for negative evaluations are so far unknown.
Objective
The purpose of this preregistered study, based on previous research on adults with borderline personality disorder (BPD), was to test whether negative evaluations of adults with CM experiences, in comparison to unexposed controls, are mediated by more negative and less positive facial affect display. Additionally, we explored whether level of depression, severity of CM, social anxiety, social support, and rejection sensitivity have an influence on ratings.
Methods
40 adults with CM experiences (CM+) and 40 non-maltreated (CM-) adults were filmed for measurement of affect display and rated in likeability, trustworthiness, and cooperativeness by 100 independent raters after zero-acquaintance (no interaction).
Results
Unexpectedly, the CM + and the CM- group were neither evaluated significantly different, nor showed significant differences in affect display. Contrasting previous research, higher levels of BPD symptoms predicted higher likeability ratings (p = .046), while complex post-traumatic stress disorder symptoms had no influence on ratings.
Conclusions
The non-significant effect could be attributed to insufficient number of participants, as our sample size allowed us to detect effects with medium effect sizes (f2 = .16 for evaluation; f2 = .17 for affect display) with a power of .95. Future research should further explore conditions (e.g., presence of specific mental disorders) under which individuals with CM are affected by negative evaluations as well as factors that contribute to negative evaluations and problems in social relationships.
Effects of 5/6 nephrectomy and high-protein diet on glomerular and tubular injuries in mice
Authors: Tanaka Shohei , Wakui Hiromichi , Azushima Kengo , Tsukamoto Shunichiro , Yamaji Takahiro , Urate Shingo , Suzuki Toru , Abe Eriko , Taguchi Shinya , Yamada Takayuki , Kobayashi Ryu , Kanaoka Tomohiko , Kinguchi Sho , Takiguchi Masahito , Funakoshi Kengo , Yamashita Akio , Ishigami Tomoaki , Tamura Kouichi 
Published: November 2022

Abstract
Numerous animal models of chronic kidney disease (CKD) have been developed. However, mice are relatively resistant to kidney injury. We aimed to evaluate the effects of high-protein diet (HPD) loading and 5/6 nephrectomy (Nx) in a susceptible strain of mice (129/Sv) over a long-term period. 129/Sv mice were divided into three groups: sham surgery (sham) + normal diet (ND) group, sham + HPD group, and 5/6 Nx + HPD group. Blood pressure, kidney function, and kidney tissue injury were compared longitudinally for 12 weeks among the three groups. The 5/6 Nx + HPD group displayed blood pressure elevation, kidney function decline, severe albuminuria, glomerular injury, and tubular injury compared with the sham + ND and sham + HPD groups. However, there was no significant difference in kidney injuries between the sham + ND and sham + HPD groups. Furthermore, the 5/6 Nx + ND group was added in comparison with the 5/6 Nx + HPD group. The glomerular injury was significantly exacerbated in the 5/6 Nx + HPD group than in the 5/6 Nx + ND group. These results indicate that HPD loading alone has little effect on kidney injury, while it exacerbates glomerular injury in the remnant kidney model.
Understanding the microstructure of a core-shell based anode catalyst layer for polymer electrolyte water electrolysis
Authors: De Angelis Salvatore , Schuler Tobias , Sabharwal Mayank , Holler Mirko , Guizar-Sicairos Manuel , Müller Elisabeth , Büchi Felix 
Published: November 2022

Abstract
Reducing precious metal loading in the anodic catalyst layer (CL) is indispensable for lowering capital costs and enabling the widespread adoption of polymer electrolyte water electrolysis (PEWE). This work presents the first three-dimensional reconstruction of a state-of-the-art TiO2-supported IrO2 based core shell catalyst layer (3 mgIrO2/cm2), using high-resolution X-ray ptychographic tomography at cryogenic temperature of 90 K. The high data quality and phase sensitivity of the technique have allowed the reconstruction of all four phases namely pore space, IrO2, TiO2 support matrix and the ionomer network, the latter of which has proven to be a challenge in the past. Results show that the IrO2 forms thin nanoporous shells around the TiO2 particles and that the ionomer has a non-uniform thickness and partially covers the catalyst. The TiO2 particles do not form a percolating network while all other phases have high connectivity. The analysis of the CL ionic and electronic conductivity shows that for a dry CL, the ionic conductivity is orders of magnitudes lower than the electronic conductivity. Varying the electronic conductivity of the support phase by simulations, reveals that the conductivity of the support does not have a considerable impact on the overall CL electrical conductivity.
Allometric options for predicting tropical tree height and crown area from stem diameter
Authors: Libalah Moses B. , Fayolle Adeline , Barbier Nicolas , Picard Nicolas , Momo Stéphane , Bocko Yannick , Mofack Gislain II , Katembo John Mukirania , Loumeto Joël , Yongo Olga Diane , Ngomanda Alfred , Couteron Pierre , Sonké Bonaventure , Vivien Rossi 
Published: November 2022

Abstract
Tree height and crown area are important predictors of aboveground biomass but difficult to measure on the ground. Numerous allometric models have been established to predict tree height from diameter (H–D) and crown area from diameter (CA–D). A major challenge is to select the most precise and accurate allometric model among existing ones, depending on the species composition and forest type where the model is to be applied. To propose a principle to select tree H–D and tree CA–D allometric models, we build a method based on k-fold cross-validation using a large dataset spanning six forest types from central Africa. We then compared the errors and biases using 22 previously established H–D and CA–D allometric model forms via three inter-comparable scenarios: locally derived for the forest type vs. regional vs. pantropical; regional (encompassing the forest type) vs. pantropical; regional (not encompassing the forest type) vs. pantropical model. H–D allometries were more variable across forest types in central Africa than CA–D allometries: (i) forest type explained 6% of the variance in H–D allometry and 2% of the variance in CA–D allometry, while species explained 9% and 2% of the variance in H–D allometry and CA–D allometry, respectively; (ii) for H–D allometry, the six forest types resulted in five best-fit models whereas, for CA–D allometry, four models provided the best fit for the six forest types. We recommend using allometric models specific to the forest type, preferentially to regional ones. Regional models should in turn be preferred to pantropical allometric models.