bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the predictive value of four insulin resistance surrogates for the prevalence of hypertension: a population-based study
Authors: Cheng Wenke , Kong Fanliang , Chen Siwei 
Published: September 2022

Abstract
Background
Several studies have investigated the association of insulin resistance (IR) surrogates and the risk of hypertension. However, it is unclear whether there exist differences between different IR surrogates and hypertension risk. Therefore, this study aimed to explore the association of four IR surrogates (triglyceride-glucose index (TyG index), triglyceride-glucose index with body mass index (TyG-BMI), triglycerides/high-density lipoprotein cholesterol ratio (TG/HDL-c), and metabolic score for IR (METS-IR)) with the prevalence of hypertension.

Methods
This is a cross-sectional study with a total of 117,056 participants. Data were extracted from a computerized database established by Rich Healthcare Group in China, which included all medical records of participants who received a health check-up from 2010 to 2016. IR surrogates were grouped into quartiles as continuous variables, and multivariate logistic regression was performed to estimate the association between different IR surrogate levels and the prevalence of hypertension. Results were expressed as odds ratios (ORs) and 95% confidence intervals (CIs). Missing data were accounted by multiple imputation. These analyses were considered as the sensitivity analysis. Meanwhile, the Bayesian network (BN) model was constructed to further evaluate the relationship between baseline characteristics and the four IR surrogates and the prevalence of hypertension, as well as the importance of every single variable for the prevalence of hypertension.

Results
Multivariate logistic regression analysis revealed that TyG-BMI and METS-IR were independent risk factors for the prevalence of hypertension that increased significantly with increasing TyG-BMI and METS-IR (p for trend < 0.001). The area under the TyG-BMI curve (AUC) was 0.681 [95% CI: 0.677–0.685], and the cut-off value was 199.5, with a sensitivity and specificity of 65.57% and 61.18%, respectively. While the area under the METS-IR curve (AUC) was 0.679 [95% CI: 0.674–0.683], and the cut-off value was 33.61, with a sensitivity and specificity of 69.67% and 56.67%, respectively. The BN model presented that among these four IR surrogates and related variables, TyG-BMI was the most important predictor of hypertension prevalence, with a significance of 34%. The results before and after multiple imputation were similar.

Conclusion
TyG-BMI and METS-IR were independent risk factors for the prevalence of hypertension. TyG-BMI and METS-IR had good predictive value for the prevalence of hypertension, and TyG-BMI was superior to METS-IR.
The relationship between high physical activity and premenstrual syndrome in Japanese female college students
Authors: Kawabe Rika , Chen Chang Yu , Morino Saori , Mukaiyama Kohei , Shinohara Yuki , Kato Masaya , Shimizu Hiroki , Shimoura Kanako , Nagai-Tanima Momoko , Aoyama Tomoki 
Published: September 2022

Abstract
Background
In recent years, moderate physical activity has attracted the attention of experts and women as a way to cope with premenstrual syndrome (PMS). Studies investigated the effects of exercise on PMS, but only a few reports focused on the relationship between physical activity, which included not only exercise but also routine bodily movements, and PMS. Therefore, the present study investigated the relationship between the amount of physical activity and PMS symptoms among sexually mature female students.

Methods
A total of 381 female university students in Japan were surveyed using a paper or web-based questionnaire with the same content. The questionnaire consisted of basic information, PMS symptoms, and physical activity based on the International Physical Activity Questionnaire (IPAQ). Participants were divided into two groups (≥ 3000 The Metabolic Equivalent of Task (MET)-minutes/week and < 3000 MET-minutes/week) based on their total physical activity as calculated using the IPAQ guidelines. The two groups were then compared in terms of the severity of their PMS physical and psychological symptoms as calculated based on the American College of Obstetricians and Gynecologists’ PMS diagnostic criteria. The Wilcoxon's rank-sum test was used for statistical analyses. We then divided the participants based on the presence or absence of each symptom and used the chi-square test to compare the intergroup differences in ratios. The statistical significance level was set at p < 0.05.

Results
Those with total physical activity of ≥ 3000 MET-minutes/week had lower total PMS symptom scores (p < 0.01), physical symptom scores (p = 0.01), and psychological symptom scores (p = 0.01) compared with those with total physical activity of < 3000 MET-minutes/week.

Conclusion
These results suggest that young women with high physical activity (≥ 3000 MET-minutes/week) have milder symptoms of PMS.
The impact of a specialist home-visiting intervention on the language outcomes of young mothers and their children: a pragmatic randomised controlled trial
Authors: Waters Cerith S. , Cannings-John Rebecca , Channon Susan , Lugg-Widger Fiona , Robling Mike , Paine Amy L. 
Published: September 2022

AbstractBackgroundYoung mothers are more likely to provide a suboptimal early language environment for their children who in turn show impairments in their language development, yet few studies have used observational methods to assess the effectiveness of home-visiting programmes in improving the language outcomes of young mothers and their children. The Family Nurse Partnership (FNP) is a licensed home-visiting intervention developed in the USA and introduced into practice in England. The intervention involves up to 64 structured home visits from early pregnancy until the child's second birthday by specially recruited and trained Family Nurses. We assessed the effectiveness of FNP in improving the language outcomes of first-time teenage mothers and their infants.MethodWe conducted a pragmatic, non-blinded, randomised controlled trial to test whether the FNP programme improved mothers’ and children’s language production at 24 months postpartum. Eligible participants were nulliparous, aged 19 years or younger, and were recruited at less than 25 weeks’ gestation from community midwifery settings (Country). Pregnant young mothers were randomly assigned to FNP plus usual care (n = 243) or usual care alone (n = 233). At 24 months postpartum, mother–child dyads were observed during a standardised free-play task with their first-born child and features of their language production was coded. Data was analysed using multi-level modelling; linear or poisson/negative binomial regression models were used as appropriate.ResultsA small effect of FNP on mothers’ productive language was detected, where mothers in the FNP group demonstrated higher mean length of utterances than mothers who received usual care alone, mean difference (adjusted by minimisation variables and by site, linear regression) = 0.10, p < .05, 95% CI (0.004–0.20), d = .18. No differences were detected between groups regarding other characteristics of maternal language or children’s language outcomes.ConclusionThis observational study conducted within the context of a randomised-controlled trial suggests that the FNP home-visiting programme may have a small, but potentially important impact on young mothers’ speech to their toddlers. Exploratory analyses identified family environment, maternal, and child related predictors of the language outcomes of young mothers and their offspring.Trial registrationThis trial is registered with ISRCTN, number ISRCTN23019866, 20/04/2009.
Investigating the factor structure of the Test of English for Academic Purposes (TEAP) and its relation to test takers’ perceived test task value
Authors: Nakamura Keita 
Published: September 2022

Abstract
Background
This study investigated the scoring and criterion-related validity of the TEAP, a newly developed Test of English for Academic Purposes. In this study, scoring validity was examined by investigating the factor structure, while criterion-related validity was examined by first investigating the longitudinal change of test takers’ perceived test task value toward the measured construct and then investigating the relationship of test takers’ perceived value to the factor structure of the TEAP.

Methods
Confirmatory item-level factor analysis was conducted using the data obtained from 2217 first-year university students comparing four models (unitary, correlated, receptive-productive, higher order). Additional confirmatory factor analyses were conducted to first investigate the longitudinal change of perceived value toward the measured construct and then to investigate the relationship of test takers’ perceived value of the construct measured by the test to the factor structure of the TEAP.

Results
The results show that the higher-order model was the best-fitting model. This confirmed a previous small-scale study suggesting the generalizability of the test’s factor structure. Furthermore, it was found that test takers’ perceived values measured at the start of university positively affected the values measured about 6 months later.
In addition, perceived values measured both at the start of university study and about 6 months later positively correlated with the higher-order factor of the test.

Conclusions
The results provide further support of the scoring validity of the test. In addition, a positive relationship between the higher-order factor of TEAP and the factors of perceived values provide evidence of the usefulness of test takers’ perception to further support the criterion-related validity of the test.
Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Authors: Misove Adela , Vicha Ales , Broz Petr , Vanova Katerina , Sumerauer David , Stolova Lucie , Sramkova Lucie , Koblizek Miroslav , Zamecnik Josef , Kyncl Martin , Holubova Zuzana , Liby Petr , Taborsky Jakub , Benes Vladimir , Pernikova Ivana , Jones David T. W. , Sill Martin , Stancokova Terezia , Krskova Lenka , Zapotocky Michal 
Published: September 2022

AbstractGliomas are the most common central nervous tumors in children and adolescents. However, spinal cord low-grade gliomas (sLGGs) are rare, with scarce information on tumor genomics and epigenomics. To define the molecular landscape of sLGGs, we integrated clinical data, histology, and multi-level genetic and epigenetic analyses on a consecutive cohort of 26 pediatric patients. Driver molecular alteration was found in 92% of patients (24/26). A novel variant ofKIAA1549:BRAFfusion (ex10:ex9) was identified using RNA-seq in four cases. Importantly, only one-third of oncogenic drivers could be revealed using standard diagnostic methods, and two-thirds of pediatric patients with sLGGs required extensive molecular examination. The majority (23/24) of detected alterations were potentially druggable targets. Four patients in our cohort received targeted therapy with MEK or NTRK inhibitors. Three of those exhibited clinical improvement (two with trametinib, one with larotrectinib), and two patients achieved partial response. Methylation profiling was implemented to further refine the diagnosis and revealed intertumoral heterogeneity in sLGGs. Although 55% of tumors clustered with pilocytic astrocytoma, other rare entities were identified in this patient population. In particular, diffuse leptomeningeal glioneuronal tumors (n = 3) and high-grade astrocytoma with piloid features (n = 1) and pleomorphic xanthoastrocytoma (n = 1) were present. A proportion of tumors (14%) had no match with the current version of the classifier. Complex molecular genetic sLGGs characterization was invaluable to refine diagnosis, which has proven to be essential in such a rare tumor entity. Moreover, identifying a high proportion of drugable targets in sLGGs opened an opportunity for new treatment modalities.
Totally laparoscopic resection using delta-shaped anastomosis of jejunal leiomyosarcoma with intussusception at the angle of Treitz: a case report
Authors: Nakamura Kenichi , Shibasaki Susumu , Yamada Seiji , Suzuki Kazumitsu , Serizawa Akiko , Akimoto Shingo , Nakauchi Masaya , Tanaka Tsuyoshi , Inaba Kazuki , Uyama Ichiro , Suda Koichi 
Published: September 2022

Abstract
Background
A leiomyosarcoma of the gastrointestinal tract is extremely rare. We report a case of jejunal leiomyosarcoma with intestinal intussusception at the angle of Treitz that was successfully treated with laparoscopic resection followed by intracorporeal reconstruction using a delta-shaped anastomosis.

Case presentation
A 54-year-old man was referred to our hospital due to fatigue and loss of appetite. Blood tests showed anemia. Enteroscopy and subsequent enterography using meglumine sodium amidotrizoate showed easily hemorrhagic tumor (10 cm in diameter) in the jejunum just beyond the angle of Treitz. Contrast-enhanced computed tomography revealed jejunojejunal intussusception. Histopathological examination of a biopsy specimen revealed a leiomyosarcoma. Laparoscopic resection of the tumor without reduction of the intussusception was performed. The resected line of the proximal intestine was very close to the ligament of Treitz in the present case. Intracorporeal jejunojejunostomy was completed using a delta-shaped anastomosis, wherein anastomosis was performed between the posterior walls of the proximal and distal jejunums after minimal mobilization around the ligament of Treitz. The patient’s postoperative course was uneventful, and he was discharged at 10 days postoperatively. No recurrence has been observed within 2 years after surgery.

Conclusions
We present a case in which a totally laparoscopic surgery for leiomyosarcoma located at the angle of Treitz with jejunojejunal intussusception was performed successfully.
A feasibility randomised controlled trial with an embedded qualitative evaluation of perinatal emotional skills groups for women with borderline personality disorder: protocol for the EASE study
Authors: Moran Paul , Bick Debra , Biddle Lucy , Borries Belinda , Kandiyali Rebecca , Rigby Janice , Seume Penny , Sadhnani Vaneeta , Smith Nadine , Swales Michaela , Turner Nicholas 
Published: September 2022

Abstract
Background
Borderline personality disorder (BPD) is a severe mental disorder characterised by emotional instability, impaired interpersonal functioning and an increased risk of suicide. There is no clear evidence about how best to help women with BPD during the perinatal period. Perinatal Emotional Skills Groups (ESGs) consist of 12 group sessions, focussing on core skills in emotion regulation, interpersonal effectiveness, distress tolerance and mindfulness and how these skills can best be utilised during the perinatal period. Prior observational research has shown that perinatal ESGs may help women with BPD. We set out to test the feasibility of conducting a randomised controlled trial to investigate the clinical effectiveness of perinatal ESGs.

Methods
A two-arm, parallel-group, feasibility randomised controlled trial of Perinatal ESGs in addition to Treatment as Usual (TAU) versus TAU for women aged over 18 years, who are likely to have a diagnosis of BPD and are either pregnant or are within 12 months of having a live birth. We will exclude women who have a co-existing organic, psychotic mental disorder or substance use dependence syndrome; those with cognitive or language difficulties that would preclude them from consenting or participating in study procedures; those judged to pose an acute risk to their baby and those requiring admission to a mother and baby unit. After consenting to participation and completing screening assessments, eligible individuals will be randomly allocated, on a 1:1 ratio, to either ESGs + TAU or to TAU. Randomisation will be stratified according to recruitment centre.
Feasibility outcomes will be the proportion of participants: (1) consenting; (2) completing baseline measures and randomised; (3) completing the intervention and (4) completing follow-up assessments. All study participants will complete a battery of self-report measures at 2 and 4 months post-randomisation. A nested qualitative study will examine participants’ and therapists’ experiences of the trial and the intervention.

Discussion
Evidence is lacking about how to help women with BPD during the perinatal period. Perinatal ESGs are a promising intervention and if they prove to be an effective adjunct to usual care, a large population of vulnerable women and their children could experience substantial health gains.

Trial registration
ISRCTN80470632.
Integral equation study of effective attraction between like-charged particles mediated by cations: Comparison between IPY2 and HNC closures
Authors: Takeda M. , Maruyama K. , Akiyama R. , Miyata T. 
Published: September 2022

AbstractEffective interactions between like-charged particles immersed in an electrolyte solution were calculated using two integral equation theories, hypernetted-chain (HNC)-Ornstein-Zernike (OZ) and ionic Percus-Yevick 2 (IPY2)-OZ. When the HNC-OZ theory was adopted, the electrolyte concentration dependence of the effective interaction showed a reentrant behavior. By contrast, the IPY2-OZ theory did not indicate the behavior. Monte Carlo simulations were performed for one of the model systems, and the results agreed qualitatively with those calculated using the HNC-OZ theory.
Stent Retriever or Aspiration Catheter Alone vs Their Combination as the First-Line Thrombectomy in Acute Stroke
Authors: Ohta Tsuyoshi , Tanaka Kanta , Koge Junpei , Yoshimoto Takeshi , Kushi Yuji , Shiozawa Masayuki , Inoue Manabu , Satow Tetsu , Iihara Koji , Ihara Masafumi , Koga Masatoshi , Toyoda Kazunori , Kataoka Hiroharu 
Published: September 2022

BACKGROUND:
The single-device simplicity for mechanical thrombectomy (MT) is now challenged by the complementary efficacy of dual-device first-line with a stent retriever and an aspiration catheter.

OBJECTIVE:
To compare the outcomes after MT initiated with a single device vs dual devices in acute anterior circulation large vessel occlusion.

METHODS:
Patients who underwent MT for acute internal carotid artery (ICA) or M1 occlusion between 2015 and 2020 were retrospectively analyzed. We divided patients into 2 groups: single-device first-line, defined as patients who underwent first-device pass with either a stent retriever or aspiration catheter, and dual-device first-line, defined as first-device pass with both devices.

RESULTS:
One hundred forty-one patients were in the single-device group, and 119 were in the dual-device group. In the dual-device group, coiling or kinking of the extracranial ICA was more frequent (P = .07) and the guide catheters were less frequently navigated to the ICA (P < .001). 37% of the single-device group was converted to dual-device use. The proportions of mTICI ≥ 2c after the first pass were similar (33% vs 32%. adjusted odds ratio 0.91, 95% CI 0.51-1.62). An mRS score of 0 to 2 at 3 months was achieved similarly (53% vs 48%, P = .46). The total cost for thrombectomy devices was lower in the single-device group (P < .001).

CONCLUSION:
The proportions of first-pass mTICI ≥ 2c were not different between the 2 groups with similar functional outcomes, although the dual-device group more likely to have unfavorable vascular conditions.
COST-EFFECTIVENESS OF USING THE LOCAL SEARCH METHOD FOR THE TASK OF OPERATIONAL PLANNING
Authors: Kozlovskaya Elena B. , Patsuk Olga V. 
Published: September 2022

A modification of the local search algorithm is considered using tournament selection for the task of operational planning in the production of plastic products. A comparative analysis of the results of the algorithm showed a direct dependence of the results on the presence of tournament selection and population size.
The program is designed for operational planning in the production of plastic products, where it is necessary to take into account the volume and period of production of each type of product with the minimum number of changes in equipment settings. The objective of optimization is to minimize the number of product shifts in the production plan. It is proposed to modify the genetic algorithm using tournament selection for the task of planning types of products at production facilities. This algorithm is a local search method that allows you to gradually improve a certain result in some vicinity of the known solution.
Purpose. The goal is to minimize the number of product shifts in the production plan.
Methodology of work: the article used methods of system analysis, operations research, optimization theories, economic and mathematical methods and statistical methods of analysis.
Results: on average, the solution is most quickly found with an initial population size of 100 individuals, and this time is less than the largest average values by 2 times. Tournament selection, reducing time costs, reduces the likelihood of finding an optimal solution.
Practical implications. Results are useful on production lines to distribute capacity loads.
Rank-Dependent Utility Under Multiple Priors
Authors: Wang Fan 
Published: September 2022

Nonlinear perception of risk is integrated into models of decision under ambiguity, thereby providing a theoretical basis for behavioral analyses that involve both risk and ambiguity. The main model replaces the risk front of maxmin expected utility by rank-dependent utility, and it is derived from simple, observable axioms that are not restricted to expected utility under risk. The model highlights the interaction between risk attitude and ambiguity attitude, and it is compatible with the paradoxical choices hypothesized by Machina. Following the same idea, nonlinear perception of risk can also be integrated into variational and multiplier preferences. When applied to comparative ambiguity attitudes, the idea enables more comparisons by allowing for both heterogeneous taste and perception of risk. This paper was accepted by Ilia Tsetlin, behavioral economics and decision analysis.
How Endogenization of the Reference Point Affects Loss Aversion: A Study of Portfolio Selection
Authors: He Xue Dong , Strub Moris S. 
Published: September 2022

Endogenization of the Reference Point Reduces Loss AversionA central idea in behavioral economics is that agents derive utility from gain and losses relative to a certain reference point and that losses loom larger than gains. In “How Endogenization of the Reference Point Affects Loss Aversion: A Study of Portfolio Selection,” He and Strub study the implications of various models of partially endogenous reference points on portfolio selection. In these models, an agent faces a salient exogenous reference point that influences the formation of endogenously determined expectations about the future, through rational expectations, optimal expectations, or mental updating of the reference point. A key finding is that the predictions of these models are identical to a model with an exogenous reference point but a lower degree of loss aversion. This suggests that it is difficult to separately identify an agent’s degree of loss aversion and his or her reference point and may help to explain why experienced and sophisticated agents appear to be less loss averse than expected in some field settings.