bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibody response with SARS-CoV-2 inactivated vaccine (CoronaVac) in Turkish geriatric population
Authors: Okyar Baş Arzu , Hafizoğlu Merve , Akbiyik Filiz , Güner Oytun Merve , Şahiner Zeynep , Ceylan Serdar , Ünsal Pelin , Doğu Burcu Balam , Cankurtaran Mustafa , Çakir Banu , Ünal Serhat , Halil Meltem Gülhan 
Published: March 2022

Abstract

Background
Sars-CoV-2 infection influences older individuals at the forefront, and there is still limited data on the COVID-19 vaccine response in the geriatric population. This study aimed to assess antibody response after vaccination with SARS-CoV-2 inactivated vaccine and examine possible factors affecting this response in a geriatric population.

Methods
individuals who have been on at least the 28th day after the second dose of the COVID-19 vaccine were included. Comprehensive geriatric assessment tools and the Clinical Frailty Scale were performed. SARS-CoV-2 spike-specific IgG antibodies were detected and, levels ≥1 U/ml were defined as seropositive, &lt;1 U/ml were defined as seronegative.

Results
a total of 497 patients were included and divided into three groups according to the days past after the second dose of the vaccine (Group 1: 28–59 days, Group 2: 60–89 days and Group 3: 90 days and more). Groups included 188, 148 and 171 patients, respectively. Seropositivity rate in each group was 80.9,73.2 and 57.3%, respectively. In Groups 1 and 2, Charlson Comorbidity Index score was higher in the seronegative group (P = 0.023 and P = 0.011, respectively). In Group 3, the prevalence of frailty was significantly higher in the seronegative group (P = 0.002).

Conclusion
to the best of our knowledge, this is the first study assessing the antibody response after vaccination with Sars-CoV 2 inactivated vaccine in the Turkish geriatric population. Moreover, this is the first study revealing the relationship between antibody response and frailty. Larger studies are needed to confirm the antibody response duration and the association between frailty and COVID-19 vaccine response.
The Natopolitan Youth
Authors: Cotton Jess 
Published: March 2022

Abstract
Childhood studies are getting older: a new wave of publications reveals a growing interest in the figure of the teenager and the various ways that the young were made an important part of the Cold War agenda. Through readings across postwar literature, culture, and social organizations that orient themselves around youth, these studies show how youth culture at once intensifies and unravels ideas of American exceptionalism. The young, as these studies show, serve as a political and culture mechanism to negotiate fantasies of national greatness and to underpin ideas of nostalgia—ideas that are at the heart of American studies’ own interest in innocent and immature figures. Despite the fantasies of consumer culture that locate freedom in the figure of the young, to grow up in the postwar US was often to exist on stilled, sentimental, or depressive time; to be at once co-opted into state agendas whilst deprived of political agency. If the teenager posed the ultimate challenge to the conformist and containment strategies of the Cold War period, it becomes an invaluable cultural subject that reveals the fantasies and the anxieties of the US’ shifting conception of itself and its imperial power in a global world.
A knowledge-driven network for fine-grained relationship detection between miRNA and disease
Authors: Yu Shengpeng , Wang Hong , Liu Tianyu , Liang Cheng , Luo Jiawei 
Published: March 2022

Abstract
Increasing biological evidence indicated that microRNAs (miRNAs) play a vital role in exploring the pathogenesis of various human diseases (especially in tumors). Mining disease-related miRNAs is of great significance for the clinical diagnosis and treatment of diseases. Compared with the traditional experimental methods with the significant limitations of high cost, long cycle and small scale, the methods based on computing have the advantages of being cost-effective. However, although the current methods based on computational biology can accurately predict the correlation between miRNAs and disease, they can not predict the detailed association information at a fine level. We propose a knowledge-driven approach to the fine-grained prediction of disease-related miRNAs (KDFGMDA). Different from the previous methods, this method can finely predict the clear associations between miRNA and disease, such as upregulation, downregulation or dysregulation. Specifically, KDFGMDA extracts triple information from massive experimental data and existing datasets to construct a knowledge graph and then trains a depth graph representation learning model based on knowledge graph to complete fine-grained prediction tasks. Experimental results show that KDFGMDA can predict the relationship between miRNA and disease accurately, which is of far-reaching significance for medical clinical research and early diagnosis, prevention and treatment of diseases. Additionally, the results of case studies on three types of cancers, Kaplan–Meier survival analysis and expression difference analysis further provide the effectiveness and feasibility of KDFGMDA to detect potential candidate miRNAs. Availability: Our work can be downloaded from https://github.com/ShengPengYu/KDFGMDA.
Computational methods, databases and tools for synthetic lethality prediction
Authors: Wang Jing , Zhang Qinglong , Han Junshan , Zhao Yanpeng , Zhao Caiyun , Yan Bowei , Dai Chong , Wu Lianlian , Wen Yuqi , Zhang Yixin , Leng Dongjin , Wang Zhongming , Yang Xiaoxi , He Song , Bo Xiaochen 
Published: March 2022

AbstractSynthetic lethality (SL) occurs between two genes when the inactivation of either gene alone has no effect on cell survival but the inactivation of both genes results in cell death. SL-based therapy has become one of the most promising targeted cancer therapies in the last decade as PARP inhibitors achieve great success in the clinic. The key point to exploiting SL-based cancer therapy is the identification of robust SL pairs. Although many wet-lab-based methods have been developed to screen SL pairs, known SL pairs are less than 0.1% of all potential pairs due to large number of human gene combinations. Computational prediction methods complement wet-lab-based methods to effectively reduce the search space of SL pairs. In this paper, we review the recent applications of computational methods and commonly used databases for SL prediction. First, we introduce the concept of SL and its screening methods. Second, various SL-related data resources are summarized. Then, computational methods including statistical-based methods, network-based methods, classical machine learning methods and deep learning methods for SL prediction are summarized. In particular, we elaborate on the negative sampling methods applied in these models. Next, representative tools for SL prediction are introduced. Finally, the challenges and future work for SL prediction are discussed.
Evidence that reduction of the apertural closing apparatus has no decisive effect on water loss in the land snail family Clausiliidae (Gastropoda: Stylommatophora)
Authors: Páll-Gergely Barna , Hettyey Attila , Turóci Ágnes , Fehér Zoltán 
Published: March 2022

Abstract
Apertural barriers of land snails are thought to increase their shell’s effectiveness against dehydration and predation. The most complex apertural barrier among stylommatophoran snails is the clausiliar apparatus (CA) of Clausiliidae. Alopia is a unique genus in having a remarkably high proportion of taxa with a naturally reduced CA, representing at least five independent reduction events. We tested the prevailing hypothesis that the primary role of the CA within the door snail family is to help retain body moisture. In a laboratory experiment, we compared the water loss of two Alopia taxa with naturally reduced and two Alopia taxa with complete CAs. There was a detectable difference in the rate of water loss, but no relationship with the presence/absence of the CA could be shown. In another laboratory experiment, this time in Alinda biplicata, we did not detect significantly higher water loss in specimens from which the clausiliar plate was artificially removed compared to those left intact.
These results suggest that the CA has no significant role in water retention but its actual function remains speculative. A possible explanation, which requires further work, could be that the CA provides protection against specific predators intruding through the aperture.
Ictal neural oscillatory alterations precede sudden unexpected death in epilepsy
Authors: Gu Bin , Levine Noah G. , Xu Wenjing , Lynch Rachel M. , Pardo-Manuel de Villena Fernando , Philpot Benjamin D. 
Published: March 2022

AbstractSudden unexpected death in epilepsy is the most catastrophic outcome of epilepsy. Each year there are as many as 1.65 cases of such death for every 1000 individuals with epilepsy. Currently, there are no methods to predict or prevent this tragic event, due in part to a poor understanding of the pathologic cascade that leads to death following seizures. We recently identified enhanced seizure-induced mortality in four inbred strains from the genetically diverse Collaborative Cross mouse population. These mouse models of sudden unexpected death in epilepsy provide a unique tool to systematically examine the physiological alterations during fatal seizures, which can be studied in a controlled environment and with consideration of genetic complexity. Here, we monitored the brain oscillations and heart functions before, during, and after non-fatal and fatal seizures using a flurothyl-induced seizure model in freely moving mice. Compared with mice that survived seizures, non-survivors exhibited significant suppression of brainstem neural oscillations that coincided with cortical epileptic activities and tachycardia during the ictal phase of a fatal seizure. Non-survivors also exhibited suppressed delta (0.5–4 Hz)/gamma (30–200 Hz) phase-amplitude coupling in cortex but not in brainstem. A connectivity analysis revealed elevated synchronization of cortex and brainstem oscillations in the delta band during fatal seizures compared with non-fatal seizures. The dynamic ictal oscillatory and connectivity features of fatal seizures provide insights into sudden unexpected death in epilepsy and may suggest biomarkers and eventual therapeutic targets.
Perceptions of delay when afflicted by an acute myocardial infarction during the first wave of the COVID-19 pandemic
Authors: Granström Johanna , Lantz Pontus , Lidin Matthias , Wahlström Maria , Nymark Carolin 
Published: March 2022

Abstract

Aims
To describe the perceptions of delay in medical care-seeking, when afflicted by an acute myocardial infarction (AMI) during the first wave of the pandemic.

Methods and results
A qualitative descriptive study with an inductive approach. Fourteen semi-structured interviews were conducted, analysed by qualitative content analysis with a manifest approach. One category and six sub-categories emerged. The decision was reached when the health threat was perceived as critical, which made the earlier thoughts of the pandemic fade away. The risk of infection during medical visits caused fear of contracting the disease. This resulted in hesitation, neglect of symptoms, and avoidance of healthcare visits. Following recommendations from authorities and media about personal responsibility was motivated by fear, affecting the care-seeking.

Conclusion
It appears that the COVID-19 pandemic raised the threshold for deciding to seek medical care when presenting with an AMI. The pandemic led to increased patient delay due to several reasons among which fear of contracting the disease was prominent. The emotion of fear was related to the external threat to one's own health, due to COVID-19, and not fear of symptoms related to an AMI. The media reporting the healthcare system as overloaded increased insecurity and may have had an influence on delay.
Air entrapment as a potential cause of early subcutaneous implantable cardioverter defibrillator malfunction: a systematic review of the literature
Authors: Ali Hussam , Lupo Pierpaolo , Foresti Sara , De Ambroggi Guido , De Lucia Carmine , Penela Diego , Turturiello Dario , Paganini Edoardo Maria , Cappato Riccardo 
Published: March 2022

Abstract

Aims
Air entrapment (AE) has been reported as a potential cause of early inappropriate shocks (ISs) following subcutaneous implantable cardioverter defibrillator (S-ICD) implantation, but a cause–effect relationship is not always evident. This systematic review aims to analyse this phenomenon concerning implantation techniques, electrogram (EGM) features, radiologic findings, and patient management.

Methods and results
A systematic search was conducted using PubMed, Embase, and Google Scholar databases following the PRISMA guidelines to obtain all available literature data since 2010 on S-ICD malfunctions possibly due to AE. The final analysis included 54 patients with AE as a potential cause of S-ICD malfunction. Overall, the aggregate incidence of this condition was 1.2%. Of ICD malfunctions possibly due to AE, 93% were ISs, and 95% were recorded within the first week following implantation. Radiologic diagnosis of AE was confirmed in 28% of the entire study cohort and in 68% of patients in whom this diagnostic examination was reported. At the time of device malfunction, EGMs showed artefacts, baseline drift, and QRS voltage reduction in 95, 76, and 67% of episodes, respectively. Management included ICD reprogramming or testing, no action (observation), and invasive implant revision in 57, 33, and 10% of patients, respectively. No recurrences occurred during follow-up, irrespective of management performed.

Conclusions
Device malfunction possibly due to AE may occur in ∼1% of S-ICD recipients. Diagnosis is strongly suggested by early occurrence, characteristic EGM features, and radiologic findings. Non-invasive management, principally device reprogramming, appears to be effective in most patients.
Enhancing seismic calving event identification in Svalbard through empirical matched field processing and machine learning
Authors: Köhler A , Myklebust E B , Mæland S 
Published: March 2022

SUMMARY
Seismic signals generated by iceberg calving can be used to monitor ice loss at tidewater glaciers with high temporal resolution and independent of visibility. We combine the empirical matched field (EMF) method and machine learning using convolutional neural networks (CNNs) for calving event detection at the Spitsbergen (SPITS) seismic array and the single broad-band station KBS on the Arctic Archipelago of Svalbard. EMF detection with seismic arrays seeks to identify all signals generated by events in a confined target region similar to single P and/or S phase templates by assessing the beam power obtained using empirical phase delays between the array stations. The false detection rate depends on threshold settings and therefore needs appropriate tuning or, alternatively, post-processing. We combine the EMF detector at the SPITS array, as well as an STA/LTA (short term average/long term average) detector at the KBS station, with a post-detection classification step using CNNs. The CNN classifier uses waveforms of the three-component record at KBS as input. We apply the methodology to detect and classify calving events at tidewater glaciers close to the KBS station in the Kongsfjord region in Northwestern Svalbard. In a previous study, a simpler method was implemented to find these calving events in KBS data, and we use it as the baseline in our attempt to improve the detection and classification performance. The CNN classifier is trained using classes of confirmed calving signals from four different glaciers in the Kongsfjord region, seismic noise examples and regional tectonic seismic events. Subsequently, we process continuous data of six months in 2016. We test different CNN architectures and data augmentations to deal with the limited training data set available. Targeting Kronebreen, one of the most active glaciers in the Kongsfjord region, we show that the best performing models significantly improve the baseline classifier. This result is achieved for both the STA/LTA detection at KBS followed by CNN classification, as well as EMF detection at SPITS combined with a CNN classifier at KBS, despite of SPITS being located at 100 km distance from the target glacier in contrast to KBS at 15 km distance. Our results will further increase confidence in estimates of ice loss at Kronebreen derived from seismic observations which in turn can help to better understand the impact of climate change in Svalbard.
Crested Wheatgrass,

L

.

Hesperius

Control, 1975
Authors: Hagen Arthur F. 
Published: March 2022

Abstract
Treatments were applied to plots located in an established stand of crested wheatgrass. The plots were 12 x 60 feet and arranged in a randomized block design with 5 replications. The test location was on the Joe Goodell farm located in Scotrs Bluff County, Nebraska. Insecticides were broadcast sprayed with a tractor mounted compressed air plot sprayer. Chemicals were mixed with water with a pH of 8.5 and applied at the rate of 5 gallons finished spray per acre. The treatment date was May 26, 1975, at which time the wheatgrass plant bug population was 89.5% adults. The remaining population was 4th and 5th instar nymphs. Pre-treatment and post-treatment plot samples of 25 sweeps per plot were obtained with a standard 12-inch diameter sweep net. Average temperature during rest period was 74.8° F. Wind velocity at application was 3 mph and at sampling varied from 5 to 7 mph. No seed or forage yield data was taken.
Cottonwood Leaf Beetle Control, 1969
Authors: Morris Robert C. 
Published: March 2022

Abstract
In June 1969 Malathion and Dursban were applied with a tractor-mounted ultra low volume sprayer to cottonwoods that had been planted as cuttings the preceeding February. Plots were single, randomly selected rows in the 400-ha planting on Choctaw Island, Arkansas City, Ark. Tree spacing was 3.75 x 3.75 m, and the soil was Robinsonville sandy Loam. C. scripta populations were counted on June 15, before spraying, and again on June 17 and 19, 24 and 72 hours after spraying.
Cottonwood Leaf Beetle Control, 1974
Authors: Morris Robert C. 
Published: March 2022

Abstract
Third-year trees in a 3.75 x 3.75 m spaced planting on Sharkey clay soil at Stoneville, Miss., were heavily infested with C. scripta. Five trees were randomly selected in the 1.62-ha area and inspected for insects on April 30, 1974. On May 3 Dursban was applied to the area with a Span-sprayer delivering 0.59 l/4iQ of spray containing 140 g ai/ha (1/8 lb/A). Post-spray collections of all target and non-target insects were made from each of the five selected trees 20 and 72 hours after spraying.
Yew,

D

.

Wistariae

Control, Indiana, 1975
Authors: Schuder Donald L. 
Published: March 2022

Abstract
An infestation of the taxus mealybug on the old wood of an ornamental planting of yews at the Grant Street Parking Garage was treated experimentally on 28 May. The application was made with a B & G Stainless Steel Sprayer operating at 30 psi. It was partly cloudy and the air temperature was 79°F. The systemic insecticides Di-Syston (rose and flower care) and Orthene 1G (CC 2663) was placed in holes opened with a shovel at four points around each shrub and then watered in with 1.5 gallons water. Every other plant was treated to avoid drift problems. The experiment was replicated 5 times. Six-inch twig samples were removed, placed in paper sacks and counts made under a binocular dissecting microscope in the laboratory.
Famphur Dose Titration for

H

.

Lineatum

Control, 1975
Authors: Bay Darrell E. 
Published: March 2022

Abstract
Mixed breed heifer, bull, and steer calves, averaging 416 lb each, were administered a 35% famphur injectable formulation by intramuscular inoculation on August 13, 1975. Twenty-six animals were assigned to each of 4 treatment groups corresponding to famphur dosage levels of 0, 1, 2, or 3 cc/100 lb body weight. Doses were calculated to the nearest whole cc. Volumes greater than 10 cc were divided in half and infected in 2 sites. Animals were examined for the appearance of warble formation on October 31, November 28, and December 19, 1975. The greatest number of warbles recorded for a single animal was used to analyze data due to variation in the times of appearance of grubs in the back.
Rabon Poultry Feed Additive Fly Larvicide, 1974-1975
Authors: Bay Darrell E. 
Published: March 2022

Abstract
Twenty-five mature hybrid cross laying hens were assigned to each of 5 treatment groups and housed in semi-individual cages for a 10-day acclimation period prior to experimental evaluation. A 1% Rabon premix in ground yellow corn (Code SD 8447 10-37-16-4PMH) was thoroughly blended with 16% protein layer mash to establish treatment levels of 0, 6, 12.5, 25, and 50 ppm Rabon. Birds received feed and water adlibitum for 7 days following which time all food was removed for 18hr prior to fecal collection to prevent contamination. Fifty newly hatched first instar house fly, stable fly, or little house fly larvae of a susceptible strain were added to 100-gm aliquots of respective fecal samples. Ten replications of the house fly and stable fly evaluations were conducted; 5 replicates of the little house fly test were performed. Samples were held at constant conditions of 27°C and 70% RH for adult emergence.
Sheep Ked Control With 1% Diazinon Dust
Authors: Pfadt Robert E. , Loyd John E. , Sharafi G. 
Published: March 2022

Abstract
Three farm flocks of sheep were power dusted with 1% diazinon sheep dust in spring of 1975 after the ewes had been shorn. All sheep in each flock were driven through a curtain of dust expelled by a Howry-Berg sheep duster. Dusting rates were determined by weighing the dust before and after treatment and timing the duration of the dusting period. Parasite density was determined by a total count of adult sheep keds on 5 lambs and 5 ewes of each flock immediately before treatment and again 6 wk later. One untreated check flock was examined for parasite density in the same manner.
Apple, Pre-Bloom Mite Treatments, 1975
Authors: Hill Clarence H. 
Published: March 2022

Abstract
Treatments of two oil formulations along with standard and experimental acaricide sprays were applied to York apples with a Bean, 35 gal per minute hydraulic sprayer at 540 psi to single tree plots replicated 5 times. The oils were applied on April 22. The 7E is the commercial 70 second viscosity superior oil. The 7E TW is a more refined, near technical white, 70 second viscosity oil. A concentrate 7E application was made on the following day. On April 25 at pre-pink stage the additional acaricides were applied. A standard spray program utilizing Captan, Sulfur, Karathane, Agri-strep, and Zolone was utilized during the test period.