bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of perinatal mortality in Aden General Hospital: A hospital-based study from Yemen
Authors: Khan Nada , Bawazeer Sami 
Published: November 2022

Background:
Perinatal mortality remains high in developing countries, including Yemen. However, information on perinatal mortality in Yemen is lacking. This study aimed to find out the perinatal mortality rate in Aden General Hospital and to analyze the causes of perinatal mortality. Materials and Methods: This descriptive study was conducted at the Obstetrics and Gynecology Department of Aden General Hospital during the period from January 1, 2003 to June 30, 2004. It was a retrospective study for the first 6 months (January–June 2003) and prospective for the remaining period (July 2003–June 2004). Results: During the study
period from January 1, 2003 to June 30, 2004, there were a total of 3770 births at Aden General Hospital, out of which there were 2976 births during the period from January to December 2003 and a further 794 births in the 6-month period from January to June
2004. The perinatal deaths were 166 (4.4%) giving a perinatal mortality rate of 44/1000 normal deliveries. Further analysis showed a total of 105 perinatal deaths in 2003 with a perinatal mortality rate of 35.3/1000 normal deliveries and 61 deaths in the period from
January to June 2004 with a rate of 77/1000 normal deliveries. Unclassified deaths including premature cases accounted for 29% (n=48) of all causes, followed by mechanical causes 36
(21.7%). The mechanical causes are divided as follows, 33 (19. 9%) due to fetal distress and 3 (1.8%) due to breech presentation. Uncertain origin causes accounted for 19.3% (n=32) of all cases of death and toxemia was observed in 16 cases (9.6%), while malformation was found in 13 (7.8%) cases. Conclusion: The perinatal mortality rate in our center was 44/1000 deliveries. The major cause of perinatal mortality was prematurity, followed by mechanical causes. The most of the mortalities occurred outside the health facilities (extra-hospital).
Clinical Pregnancy Rate in in-Vitro Fertilization (IVF) among Endometrioma Patients Underwent Cystectomy Laparoscopy
Authors: Kurniawan Andrew , Ulfa Maryam , Surya Raymond , Hestiantoro Andon 
Published: November 2022

Abstract
Objective: to discuss the clinical pregnancy rate and factors influencing fecundity among endometriosis women having cystectomy laparoscopically who underwent IVF.
Methods: The search was conducted on Pubmed®, EBSCOhost®, and Proquest®, Cochrane Library®, ClinicalKey® using MeSH.
Case : A 38-years woman, P0A0 come to the gynecology clinic with a chief complaint of primary infertility for eight years. The patient had undergone a bilateral endometrial cyst resected with laparoscopy and failed for two cycles of IVF. What is the clinical pregnancy rate of women that undergo IVF with a history of ovarian endometrioma cystectomy?
Results:, There were six articles appropriate to the inclusion criteria and further appraised using the Centre for Evidence-Based Medicine, University of Oxford appraisal tools. The studies consisted of five prognostic studies and one meta-analysis. The studies were appraised for their validity, Importance, and Applicability.
Conclusion: The pregnancy rate in patients undergoing IVF after ovarian cystectomy ranges from 14%-45.2%. A prudent consideration and carefulness during cystectomy surgery are essential for patients that wish to be fertile.
Keywords: clinical pregnancy rate, endometrioma, in vitro fertilization, laparoscopy, ovarian cystectomy

Abstrak
Tujuan: Untuk menelaah tentang kemungkinan terjadinya kehamilan secara klinis pada perempuan yang menjalani IVF dengan riwayat laparoskopi sistektomi dan faktor-faktor yang mempengaruhi kesuburannya.
Metode: Pencarian jurnal dilakukan dengan menggunakan search engine Pubmed®, EBSCOhost®, dan Proquest®, Cochrane Library®, ClinicalKey® menggunakan MeSH.
Kasus: Perempuan P0A0 berusia 38 tahun datang ke poliklinik dengan keluhan utama infertilitas selama delapan tahun. Pasien memiliki riwayat kista endometrioma bilateral yang sudah di kistektomi dengan laparoskopi dan dua kali gagal menjalani siklus IVF. Berapa kemungkinan terjadinya kehamilan secara klinis pada perempuan yang menjalani IVF dengan riwayat kistektomi endometrioma?
Hasil: Dari hasil pencarian didapatkan enam artikel jurnal yang sesuai dengan kriteria inklusi dan dianalisis lebih lanjut menggunakan telaah kritis Evideence-Based Medicine, University of Oxford. .Terdapat lima jurnal studi prognostic dan satu meta-analisis. Studi-studi tersebut akan ditelaah kritis lebih lanjut berdasarkan validitas, kepentingan, dan aplikabilitasnya
Kesimpulan: Kemungkinan terjadinya kehamilan secara klinis pada pasien yang menjalani IVF setelah kistektomi endometrioma ovarium adalah 14%-45,2%. Pertimbangan yang bijaksana dan hati-hati diperlukan untuk melakukan operasi kistektomi pada pasien yang mengalami endometrioma dan ingin tetap subur.
Kata kunci: endometrioma, fertilisasi in vitro, kehamilan klinis, kistektomi ovarium, laparoskopi
EMA and EMACO Chemotherapy in High Risk Gestational Trophoblast Disease, which Better?
Authors: I Gde S. Winata  , Putra A. E. Aricandana  
Published: November 2022

Abstract
Objective: Determine the best effectiveness and efficacy between EMA and EMACO for patients with high-risk GTN.
Results: GTN patients who received EMA showed remissions as high as 74.4% - 96.6% of cases. The side effects of anemia in EMA were less toxic than EMACO, but it wasn’t the case in neutropenia. Two studies showed that 57,1% and 87% patients relapse within 2 years, while none in 5 years and 7 years follow-ups.
Discussion: With EMACO use, it has been observed to result in increased morbidity and increased health care costs and when patients experience complications while staying overnight in the hospital, they are not monitored by a good specialist team. Patients treated with EMACO had more peripheral neuropathy as result of vincristine than EMA. The use of EMA certainly requires further evaluation.
Conclusion: Patients with High-risk GTN who treated first-line with EMA or EMACO have an excellent prognosis. Both regiments are equally effective. There were differences in treatment scheduling, hospitalization requirements, and toxicity between regimens.

Keywords: EMA, EMACO, gestational trophoblastic neoplasia

Abstrak:
Tujuan: Mengetahui efektivitas dan efikasi terbaik diantara EMA dan EMACO untuk pasien dengan NTG berisiko tinggi.
Hasil: Pasien dengan NTG yang menerima EMA menunjukkan remisi setinggi 74.4%-96.6% dari kasus. Efek samping anemia dari EMA lebih tidak toksik dibandingkan EMACO, namun tidak dengan neutropenia. Dua studi menunjukkan bahwa 57.1% dan 87% pasien mengalami kekambuhan dalam 2 tahun, namun tidak ada dalam follow up 5 tahun dan 7 tahun.
Diskusi: Dengan penggunaan EMACO, dapat diobservasi bahwa terdapat peningkatan morbiditas dan peningkatan biaya pelayanan kesehatan, dan ketika pasien mengalami komplikasi pada saat rawat inap di rumah sakit, mereka tidak dimonitor oleh tim spesialis yang baik. Pasien yang diterapi dengan EMACO memiliki efek samping neuropati perifer lebih tinggi yang disebabkan oleh vinkristin, dibandingkan EMA. Penggunaan EMA membutuhkan evaluasi lebih lanjut.
Kesimpulan: Pasien dengan NTG berisiko tinggi yang diterapi dengan lini pertama EMA atau EMACO mempunya prognosis yang baik. Kedua regimen tersebut efektif. Ada perbedaan dalam penjadwalan terapi, kebutuhan rawat inap dan toksisitas antara regimen,
Kata kunci: EMA, EMACO, neoplasia trofoblastik gestasional
How the Type of Surgery and Adherence to the Clinical Pathway Correlate with Quality Control and Cost Control in Endometriosis Surgery
Authors: Muharam Natadisastra  , Alda Yohanes , Meutia Alfa P. 
Published: November 2022

Objective: This study examined the correlation of the type of surgery and adherence to the clinical pathway corresponding to the national guidelines in terms of quality and cost control.
Methods : Quantitative economic evaluation was conducted to assess the type of surgery and adherence to clinical pathways in terms of quality and cost control. The data were analyzed using the chi-square or Mann–Whitney test.
Results : Of the sample of 82 patients who had undergone laparoscopy or laparotomy, 54.9% had a laparoscopic procedure, while 45.1% had undergone laparotomy ; only 25.6% of the case procedures adhered to the clinical pathway. In general, it can be interpreted that, in a laparoscopy procedure, the potential risk that a mismatch will occur in quality control is up to 32 times that of a laparotomy procedure. Moreover, good adherence to the clinical pathway does not correlate with good cost control. Overall, of the 82 cases, only three (3.7%) showed a good fit for both quality control and cost control.
Conclusions : The type of surgery correlates with quality and cost control, whereas adherence to the clinical pathway does not correlate with either quality or cost control.
Keywords: Laparotomy, Laparoscopy, surgery, endometriosis, national health insurance
Abstrak
Tujuan: Studi ini menguji korelasi jenis operasi dan kepatuhan terhadap jalur klinis yang sesuai dengan pedoman nasional dalam hal kontrol kualitas dan biaya.
Metode: Evaluasi ekonomi kuantitatif dilakukan untuk menilai jenis operasi dan kepatuhan terhadap jalur klinis dalam hal kualitas dan pengendalian biaya. Data dianalisis menggunakan uji chi-square atau Mann-Whitney.
Hasil: Dari sampel 82 pasien yang pernah menjalani laparoskopi atau laparotomi, 54,9% menjalani prosedur laparoskopi, sedangkan 45,1% pernah menjalani laparotomi ; hanya 25,6% dari prosedur kasus yang mengikuti jalur klinis. Secara umum dapat diartikan bahwa, dalam prosedur laparoskopi, potensi risiko terjadinya ketidaksesuaian dalam kontrol kualitas adalah hingga 32 kali lipat dari prosedur laparotomi. Selain itu, kepatuhan yang baik terhadap jalur klinis tidak berkorelasi dengan pengendalian biaya yang baik. Secara keseluruhan, dari 82 kasus, hanya tiga (3,7%) yang menunjukkan kesesuaian yang baik untuk pengendalian kualitas dan pengendalian biaya.
Kesimpulan: Jenis pembedahan berkorelasi dengan kualitas dan pengendalian biaya, sedangkan kepatuhan terhadap jalur klinis tidak berkorelasi dengan kualitas atau pengendalian biaya.
Kata kunci: Laparotomi, Laparoskopi, pembedahan, endometriosis, jaminan kesehatan nasional
Budaya Egalitarian Pemerintah Desa dalam Perbaikan Badan Usaha Milik Desa (BUMDes)
Authors: Rahmatia Rahmtia Rahmatia 
Published: November 2022

The purpose of this study is to describe the egalitarian cultural problems of the concept of BUMDes power in North Gorontalo Regency. The methods used qualitative research methods. Based on the results of the study it was found that; (1) The mindset of the community is still minimal in making product innovations from their natural and cultural wealth; (2) The entrepreneurship program supported by the Village Fund has not been able to encourage increased changes in the economic growth of the village, and (3) There has been no cooperation with external parties in building a market network to sell innovative products. So it can be concluded that, the concept of egalitarian culture towards changes in the bureaucracy of BUMDes can be carried out if it gets support from business actor agents.
Pengaruh Ukuran Perusahaan, Kebijakan Hutang dan Profitabilitas Terhadap Nilai Perusahaan Pada PT Gudang Garam Tbk Periode 2010-2021
Authors: Lutfi Asep Muhammad 
Published: November 2022

This study aims to analyze the effect of the firm size ratio, debt policy ratio and profitability ratio on the firm value ratio at PT Gudang Garam Tbk. The data used in this study is secondary data from the company's financial statements from 2010–2021. The methodology used is classical assumption test, simple linear regression analysis, multiple linear regression analysis, determinant coefficient and hypothesis testing. Based on the test results, firm size and debt policy have no partial effect on firm value, profitability has a partial effect on firm value, firm size, debt policy and profitability has a simultaneous effect on firm value. The results of the R2 test show that Company size, debt policy and profitability have an influence of 69% on Firm Value while the remaining 31% is influenced by other factors. which means that there is no effect of Firm Size, Debt Policy and Profitability will reduce Firm Value of 38,809. In this case, the increase in Firm Size, Debt Policy and Profitability will have a positive effect on Firm Value. From the results of the T-Test Firm Size and Debt Policy have no partial effect on Firm Value, Profitability has a partial effect on Firm Value. From the results of the F test, firm size, debt policy and profitability have a simultaneous effect on firm value.
ظاهرة التَّشدد وعلاجها في ضوء السّنة النبوية
Authors: Samarh Samer Najeh 
Published: November 2022

This research aims at shedding the light on the phenomenon of extremism and its treatment in the light of the Sunnah by collecting and studying hadiths related to the subject to attain a perception of the prophetic approach in dealing with this ill, namely: prevention and treatment. The research has elucidated the concept of extremism and its relationship with other concepts related to delving deeper andÂ exaggerationÂ Â andÂ revealed the main reasons driving the person to be extreme and practice it. Besides, the research showed the means of the Prophetic Sunnah to treat and eliminate extremism through an integrated plan based on two methods; (1)Â Prevention of extremism through warning against it and explaining its negative consequences to the individual and societyÂ as well, (2)Treatment of extremism if occurring by correcting the extremist's understanding through guiding him or her to the methods and means that help them continue their doings, and ending with punishing the extremists based on his or her condition and his or her impact on the community around him.
Spatial Analysis of Ottoman Hammams in Erzurum
Authors: Kulak Torun Firdevs , İsmailoğlu Semiha 
Published: November 2022

Throughout history, water has been one of the defining elements of life in all cultures. In line with the needs of society, public spaces have been designed for their access to water. Baths are also structures built for faith, cleanliness and health. The study examines the spatial organisation in the Ottoman Period baths through examples. Following this, the baths in Erzurum, a winter city, are discussed. Within the scope of the study, 13 baths in the Yakutiye district of Erzurum, which still exists today, were examined through literature and plan drawings. As a result of the evaluations, it was determined that, in some, the function has changed, while others have undergone spatial changes. Only two of Erzurum's hammams have undergone a function change, namely Askeri Hammam and Şeyhler Hammam. Although Gümrük Hammam continues to preserve its function, it is no longer operational. Other hammams, however, still operate in the same way. This study draws attention to the baths that had particular importance for cleanliness, health and rituals during the period. The study area is located in Eastern Anatolia, home to many Ottoman-era baths in Turkey; it is bordered by the city of Erzurum, which has been home to many civilisations. This study contributes to the literature on how the culturally important baths of the Ottoman Period are organised as a place.
KDEON WK-11: A short antipseudomonal peptide with promising potential
Authors: Casciaro Bruno , Loffredo Maria Rosa , Cappiello Floriana , O’Sullivan Niamh , Tortora Carola , Manzer Rizwan , Karmakar Sougata , Haskell Alan , Hasan Syed K. , Mangoni Maria Luisa 
Published: November 2022

The plight of antimicrobial resistance continues to limit the availability of antibiotic treatment effective in combating resistant bacterial infections. Despite efforts made to rectify this issue and minimise its effects on both patients and the wider community, progress in this area remains minimal. Here, wede-novodesigned a peptide named KDEON WK-11, building on previous work establishing effective residues and structures active in distinguished antimicrobial peptides such as lactoferrin. We assessed its antimicrobial activity against an array of bacterial strains and identified its most potent effect, againstPseudomonas aeruginosawith an MIC value of 3.12 μM, lower than its counterparts developed with similar residues and chain lengths. We then determined its anti-biofilm properties, potential mechanism of action andin vitrocytotoxicity. We identified that KDEON WK-11 had a broad range of antimicrobial activity and specific capabilities to fightPseudomonas aeruginosawith lowin vitrocytotoxicity and promising potential to express anti-lipopolysaccharide qualities, which could be exploited to expand its properties into an anti-sepsis agent.
A low-cost naphthaldiimide based organic cathode for rechargeable lithium-ion batteries
Authors: Wang Zhuo , Zhang Pengchao , Li Junpeng , Zhang Chong , Jiang Jia-Xing , Lv Menglan , Ding Zhengping , Zhang Bin 
Published: November 2022

Recently, the development of cathode materials is becoming an important issue for lithium-ion batteries (LIBs). Compared with inorganic cathodes, the organic cathodes are developing rapidly, ascribing to their distinct merits in light weight, low cost, massive organic resources and high capacity. In this paper, a cost-efficiency naphthaldiimide (NDI) based derivative, 2,7-bis(2-((2-hydroxyethyl) amino) ethyl) benzo[lmn] [3,8] phenanthroline-1,3,6,8(2H, 7H)-tetraone (NDI-NHOH), was used as organic cathode in LIBs. The NDI-NHOH was synthesized easily via one-step process, and it showed very high thermal stability. Through mixing NDI-NHOH with acetylene black and polyvinylidene fluoride (weight ratio of 6:3:1) as composite cathode in lithium-metal based LIBs, the NDI-NHOH presented versatile electrochemical properties. From cyclic voltammetry (CV) test, it exhibited two reversible peaks for oxidation and reduction in the first cycle, respectively. Notably, the oxidation and reduction peaks were located at 2.54, 3.22 and 2.14, 2.32 V vs. Li+/Li, respectively. By employing NDI-NHOH as cathode, it demonstrated a specific capacity of about 80 mAh g−1 in the range of 1.5–3.5 V, where the batteries retained a capacity retention of 50% over 20 cycles. According to the LIBs study, it suggests that the NDI-NHOH-based derivative shows a potentially promising candidate as efficient organic cathode materials for high-performance metal-ions batteries.
Predictive value of left ventricular dyssynchrony for short-term outcomes in three-vessel disease patients undergoing coronary artery bypass grafting with preserved or mildly reduced left ventricular ejection fraction
Authors: Liu Jia , Fan Rui , Li Cui-ling , Liu Yan-qiu , Liu Dong-hong , Li Wei , Yao Feng-juan 
Published: November 2022

Background and objectiveCoronary artery bypass grafting (CABG) is the reference standard intervention in coronary artery disease (CAD) patients with three-vessel disease (3VD). We aimed to evaluate the predictive value of left ventricular (LV) dyssynchrony for short-term adverse outcomes in patients with 3VD undergoing CABG with preserved or mildly reduced LV ejection fraction (LVEF).Materials and methodsThis study involved ninety-five 3VD patients with preserved or mildly reduced LVEF undergoing scheduled on-pump CABG. The pre-operative diameters and volumes of LV and LVEF were obtained by two-dimensional echocardiography. LV dyssynchrony parameters were acquired by real-time three-dimensional echocardiography (RT-3DE) and analyzed by HeartModel quantification software. And the perfusion index of LV was obtained by contrast echocardiography. The clinical endpoints of short-term adverse outcomes comprised 30-day mortality and/or composite outcomes of postoperative complications. Univariate and multivariate logistic regression analyses were used to identify risk factors for the occurrence of post-CABG short-term adverse outcomes.ResultsShort-term adverse outcomes occurred in 12 (12.6%) patients. These patients had higher LV dyssynchrony parameters obtained through RT-3DE. The standard deviation (SD) of the time to minimum systolic volume (Tmsv) corrected by heart rate over 16 segments (Tmsv16-SD%) [odds ratio (OR), 1.362; 95% confidence interval (CI) (1.090–1.702); P = 0.006], one of the LV dyssynchrony parameters, was independently associated with short-term adverse outcomes. Patients with poor synchronization tended to spend more time in the intensive care unit (ICU) and hospital after surgery.ConclusionPre-operative LV dyssynchrony parameter Tmsv16-SD% obtained through RT-3DE could be a useful additional predictor of postoperative short-term adverse outcomes in 3VD patients with preserved or mildly reduced LVEF undergoing CABG.
Investigation on the differences of hemodynamics in normal common carotid, subclavian, and common femoral arteries using the vector flow technique
Authors: Song Di , Liu Mengmeng , Dong Yinghui , Hong Shaofu , Chen Ming , Du Yigang , Li Shuangshuang , Xu Jinfeng , Gao Wenjing , Dong Fajin 
Published: November 2022

ObjectivesTo investigate the feasibility of the vector flow imaging (V Flow) technique to measure peripheral arterial hemodynamic parameters, including wall shear stress (WSS) and turbulence index (Tur) in healthy adults, and compare the results in different arteries.Materials and methodsFifty-two healthy adult volunteers were recruited in this study. The maximum and mean values of WSS, and the Tur values at early-systole, mid-systole, late-systole, and early diastole for total 156 normal peripheral arteries [common carotid arteries (CCA), subclavian arteries (SCA), and common femoral arteries (CFA)] were assessed using the V Flow technique.ResultsThe mean WSS values for CCA, SCA, and CFA were (1.66 ± 0.68) Pa, (0.62 ± 0.30) Pa, and (0.56 ± 0.27) Pa, respectively. The mean Tur values for CCA, SCA, and CFA were (0.46 ± 1.09%), (20.7 ± 9.06%), and (24.63 ± 17.66%), respectively. The CCA and SCA, as well as the CCA and CFA, showed statistically significant differences in the mean WSS and the mean Tur (P &lt; 0.01). The mean Tur values had a negative correlation with the mean WSS; the correlation coefficient between log(Tur) and WSS is −0.69 (P &lt; 0.05).ConclusionV Flow technique is a simple, practical, and feasible quantitative imaging approach for assessing WSS and Tur in peripheral arteries. It has the potential to be a useful tool for evaluating atherosclerotic plaques in peripheral arteries. The results provide a new quantitative foundation for future investigations into diverse arterial hemodynamic parameters.