bluuebunny/crossref_metadata_2025_split huggingface dataset:
FIRST REPORT OF FUNGAL PALYNOMORPHS FROM THE ZECHSTEIN GROUP (LOPINGIAN): IMPLICATIONS FOR THE STRATIGRAPHIC COMPLETENESS OF THE EARTH'S PALEOZOIC FUNGAL RECORD
Authors: GIBSON MARTHA E. 
Published: June 2022

ABSTRACTPalynological study of the Permian–Triassic boundary has typically focused on the pollen grain and spore content to reconstruct vegetation, with fungal remains either left unidentified or set aside for future research. Paleozoic fungal microfossil records in particular are lacking. The Zechstein Group (∼ 258–252 Ma; Lopingian) is a remarkable stratigraphic sequence of stacked carbonates and evaporites. High-resolution palynological analysis of new borehole cores through the Zechstein Group of northeast England has revealed its entire sedimentological history and enabled a new reconstruction of vegetation dynamics in central-western Europe preceding the Permian–Triassic boundary. Assemblages composed of conifers, pteridosperms, pteridophytes, sphenopsids, and cycads/ginkgoes were recovered alongside fungal remains throughout the entire sequence. Four fungal morphologies were observed, the most common being smooth-walled spheroidal inclusions of an endobiotic Chytridiomycota or Hypochytridiomycota affinity. Other evidence of fungi includes epiphytic Callimothallus-type fungi (Family Microthyraceae), the dematiaceous Chaetomium-like mold (Family Chaetomiaceae) found associated with soil, cellulose and plant debris, and possible evidence of chytrid-induced pitting on the surface of plant cuticle. This is the first study to highlight the fungal content of Zechstein palynological preparations and while occurrences are rare, they provide new insight into the composition of the Zechstein forest understory, reinforcing the interpretation that the upper Zechstein environment was humid. This work improves our understanding of the taxonomic and functional diversity of fungal taxa associated with evaporite systems during the Lopingian, and highlights the exceptional preservation potential of halite, combating underestimates of fungal richness in the fossil record.
A Meshless Numerical Modeling Method for Fractured Reservoirs Based on Extended Finite Volume Method
Authors: Rao Xiang , Zhao Hui , Liu Yina 
Published: June 2022

Summary
In this paper, a meshless numerical modeling method named mesh-free discrete fracture model (MFDFM) of fractured reservoirs based on the newly developed extended finite volume method (EFVM) is proposed. First, matching and nonmatching point cloud generation algorithms are developed to discretize the reservoir domain with fracture networks, which avoid the gridding challenges of the reservoir domain in traditional mesh-based methods. Then, taking oil/water two-phase flow in fractured reservoirs as an example, MFDFM derives the EFVM discrete scheme of the governing equations, constructs various types of connections between matrix nodes and fracture nodes, and calculates the corresponding transmissibilities. Finally, the EFVM discrete scheme of the governing equations and the generalized finite difference discrete scheme of various boundary conditions form the global nonlinear equations, which do not increase the degree of nonlinearity compared with those in the traditional finite volume method (FVM)-based numerical simulator. The global equations can be solved by the existing nonlinear solver in the FVM-based reservoir numerical simulator by only adding the linear discrete equations of boundary conditions, which reduce the difficulty of forming a general purpose MFDFM-based fractured reservoir numerical simulator. Several numerical test cases are implemented to illustrate that the proposed MFDFM can achieve good computational performance under matching and nonmatching point clouds, and for heterogeneous reservoirs, complex fracture networks, complex boundary geometry, and complex boundary conditions, by comparing the computational results of MFDFM with embedded discrete fracture model (EDFM). Thus, MFDFM retains the computational performances of the traditional mesh-based methods and can avoid the difficulties of handling complex geometry and complex boundary conditions of the computational domain, which is the first meshless numerical framework to model fractured reservoirs in parallel with the mesh-based discrete fracture model (DFM) and EDFM.
Comparison of life history traits of two populations of Hermetia illucens (Diptera: Stratiomyidae): implications for larval biomass production
Authors: MASSE Paul Serge MBENOUN , GBETKOM Loudh MBANSIE , LIBONG Sipora Glwadys NGO , TOTUOM Clarette Sidoine MAMNO , BILONG Charles Felix BILONG 
Published: June 2022

Abstract
The Black Soldier Fly (BSF) Hermetia illucens is widely studied as a sustainable alternative source of protein. Herein, we investigated the relationship of life history traits between wild population (WP) and domesticated population (DP) of H. illucens. Prepupa stages of both populations were maintained under the same rearing conditions from July 2020 to June 2021. Our results show that the pupation time was longer in WP (10.25 ± 2.66 days) than in DP (7.2 ± 1.1 days). In contrast, the emergence time of BSF adults was shorter in WP (8.3 ± 2.2 days) than in DP (9.7 ± 1.8 days). The courtship was nearly similar in both populations. Mounting and reverse coupling were the two different copulation models used by BSF adults in WP while reverse coupling dominated in DP. The BSF females laid more eggs in WP (1468.75 ± 593.09 eggs) than in DP (246.21 ± 96.23 eggs). The egg stage was similar in length and width in both populations while the morphometric traits in the larval, pupal and adult stages were consistently lower in domesticated than in wild population. The life span of adults (males and females) was longer in DP than in WP. Our findings indicate higher values of morphological traits in WP than in DP, and distinct mating and reproductive behaviours between both populations. Wild population of H. illucens might be more suitable for larval mass production and might serve as an alternative source of protein that could substitute the expensive commercial food used to feed poultry and fish.
Exploring waste and sanitation-borne hazards in Rohingya refugee camps in Bangladesh
Authors: Uddin Sayed Mohammad Nazim , Gutberlet Jutta , Chowdhury Anika Tasnim , Parisa Tahlil Ahmed , Nuzhat Samiha , Chowdhury Sidratun Nur 
Published: June 2022

AbstractImproper sanitation and waste management is the number one cause for ill health, disease and death throughout the world, particularly under extremely dense living conditions in refugee camps in the global South. This paper discusses the results of a mixed-method study conducted in Rohingya refugee camps, located in Chittagong, Bangladesh, currently hosting the world's largest concentration of refugees. Our structured questionnaire, group discussion and interviews were centered on waste-borne hazards. The research has evidenced severe challenges associated with overall precarious sanitation and waste situations in the camps. Garbage littering and open defecation are widely practiced. Congested drainage systems contribute to flooding, bringing waste and contaminants into people's homes. Improvements can be made by involving camp inhabitants in decision-making processes and giving them greater ownership in everyday infrastructure maintenance. Our research suggests that community participation is the key tool to maintain proper cleanliness of drains and toilets. Creating a stronger sense of community in the camps and practicing transparency and inclusion in planning and decision-making can contribute to addressing the key threats identified in this research and also apply to other refugee camps worldwide, with similar hazardous living conditions.
Impact of irrigation with Lake Abaya water on soil quality – southern Rift Valley, Ethiopia
Authors: Setegn Yalelet Abera , Kassa Kinfe , Dagalo Samuel , Tsegaye Dereje 
Published: June 2022

AbstractThe study's aim was to assess the impact of using water from Lake Abaya for irrigation and its impact on soil quality at Mirab Abaya, Ethiopia. Six water samples from the edge of Lake Abaya and 30 (18 irrigated and 12 rain-fed) composite soil samples from farm lands in Wajifo, Fura and Algae were collected. Analyses showed that the use of water from Lake Abaya will bring a soil salinity hazard in future. The soil analyses showed variations in space and time in the physico-chemical components in the study area. The highest salinity was reported from Algae, the closest site to the Lake. The highest soil alkalinity was reported from Wajifo, which has a long irrigation history. The irrigated soils reported higher salinity than the rain-fed soils, indicating that water from Lake Abaya can affect irrigated soil quality. In general, Lake Abaya water is not suitable for salt-sensitive crops and caution is required in using it for irrigation.
Retracted: Design and development of an integrated environmental waste management system with a sustainable solution
Authors: Wang Xinman 
Published: June 2022

ABSTRACT
Water Supply issues a formal retraction in relation to the above article by Xinman Wang. The publisher issues this retraction due to concerns that were raised regarding potential citation manipulation due to inappropriate references. The journal did not receive a satisfactory response to these concerns and as such the Editors-in-Chief no longer have confidence in the integrity of the article.
In Silico Design, Synthesis and Evaluation of Hydroxyxanthone Derivatives
as Potential Anti-diabetic Agents Targeting α-glucosidase
Authors: Saikia Riya , Das Aparoop , Pathak Kalyani , Gogoi Neelutpal , Paul Tirna , Sahariah Jon Jyoti , Sarma Himangshu 
Published: June 2022

Background:
Glucosidase is a catalytic enzyme that catalyzes, specifically hydrolyses, the carbohydrates to free glucose units in blood in the last step of carbohydrate metabolism. So far, many compounds with α-glucosidase inhibitory activity for example, acarbose, voglibose etc., have been accounted and commercialized for diabetes therapy. However, Xanthones are recognized as efficient glucosidase inhibitors because of their planar structure and thereby opens the door for the researchers to utilize the same for designing and developing potent and novel hybrid xanthones for anti-diabetic therapy.

Objectives:
The current study aimed to determine and evaluate the anti-diabetic potential of different synthetic hydroxylxanthone derivatives using Nicotinamide and Streptozotocin(60mg/kg i.p.) induced diabetic rats.

Methods:
The partially purified synthetic hydroxyxanthone derivatives namely A1,A2, A3, A4, and A5 were administered to diabetic rats with a dose of 150mg/kg, per oral(p.o.) and the effect of the fraction on blood glucose level was studied upto 21 days. Further, the synthetic compounds were subjected to spectral analysis for their characterization.

Results:
The in-silico molecular docking results indicated that the compound A3 has shown the best binding energy score. Also, the in-vivo anti-diabetic potential of the synthetic hydroxyxanthone derivatives have revealed that the compounds A3 and A2 were significantly effective in controlling the blood glucose level when compared to the standard drug miglitol. In addition, compounds A3 and A2 were found to be effective in restoring the enzymes of liver and lipid profile in Streptozotocin-induced Wistar rat models.

Conclusion:
With an objective to investigate the compounds for predicting biological activity, it was found that the hydroxyxanthonepossesses a safety margin for toxicity and acts as a lead towards the development of potential α-glucosidase inhibitors. These compounds show excellent correlation between docking results, synthetic data and in-vivo anti-diabetic activity. However, further modifications can be done to enhance the potency, binding affinity profile and minimize toxicity.
ETIOTROPIC THERAPY OF FUNGAL INFECTIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Kravchun N. A. , Kogan B. G. 
Published: June 2022

The term "diabetes mellitus" refers to metabolic disorders of various etiologies, characterized by the development of chronic hyperglycemia, accompanied by changes in carbohydrate, fat and protein
metabolism, is the result of a defect in secretion and insulin action.Diabetes is one of the factors risk of development and fungal damage
stop. He suffers from fungal skin diseases over 35% of the population over the age of 40 and almost 45% of patients with type 2 diabetes.
PRIMARU HYPERALDOSTERONISM
Authors: Kravchun N. A. , Polozova L. G. 
Published: June 2022

By definition, published mu in clinical guidelines for diagnosticism and treatment of primary hyperal
preteronism, primary hyporalldosteronism - collective diagnosis characterized by increased the level of aldosterone, which is relative
but independent of the renin-angiotensin system stem and does not decrease with sodium load.
Urethral strictures caused by lichen sclerosus: evaluation of patient quality of life after buccal urethroplasty
Authors: Usupbaev A. Ch. , Kurbanaliev R. M. , Akylbek S. , Stambekova K. N. , Mukanbaev K. 
Published: June 2022

Introduction. In modern medical practice, when conducting clinical trials to assess the effectiveness of the treatment, it has long been recognized that the quality of life of a patient is a highly informative indicator of the assessment of health status. Buccal urethroplasty is one of the most effective methods of surgical treatment of urethral stricture disease in men with scleroatrophic lichen.Materials and methods. Twenty-five patients with urethral stricture caused by scleroatrophic lichen aged 17 to 80 years were examined. All patients underwent buccal urethroplasty. Patient quality of life was assessed 1, 6, and 12 months after buccal urethroplasty using the SF-36 Health Status Survey, the International Prostate Symptom Score (IPSS; Quality of Life — QoL) and urodynamic studies. In addition, a survey of patients was conducted on the subject of satisfaction with the results of the operation.Results. The results of the survey reliably indicate the high efficiency of buccal urethroplasty, reflected in the dynamics of physical indicators (62.5 ± 0.7 vs 71.7 ± 0.9 vs 95.5 ± 1.0 vs 97.2 ± 1.1; p < 0.05) and psychological (69.2 ± 1.1 vs 77.0 ± 0.7 vs 92.2 ± 0.8 vs 96.2 ± 1.0; p < 0.05) well-being according to the SF- 36, IPSS total score (32.1±3.4 vs 15.0±2.7 vs 7.3±2.9 vs 6.8±2.4; p < 0.05) and QoL index (5.5 ± 1.2 vs 3.8 ± 1.7 vs 1.6 ± 1.5 vs 1.4 ± 1.4, p < 0.05). The maximum urine flow rate increased to 19.5 ± 1.2 ml/s one month after surgery, to 23.7 ± 1.7 ml/s after six months, and to 25.8 ± 1.3 ml/s after 12 months, compared to preoperative values of 15.8 ± 1.2 ml/s (p < 0.05).Conclusion. Replacement of affected urethral tissues with scleroatrophic lichen with buccal flap helps restore adequate urination and improve patient quality of life.
A Remote Digital Monitoring Platform to Assess Cognitive and Motor Symptoms in Huntington Disease: Cross-sectional Validation Study
Authors: Lipsmeier Florian , Simillion Cedric , Bamdadian Atieh , Tortelli Rosanna , Byrne Lauren M , Zhang Yan-Ping , Wolf Detlef , Smith Anne V , Czech Christian , Gossens Christian , Weydt Patrick , Schobel Scott A , Rodrigues Filipe B , Wild Edward J , Lindemann Michael 
Published: June 2022

Background
Remote monitoring of Huntington disease (HD) signs and symptoms using digital technologies may enhance early clinical diagnosis and tracking of disease progression, guide treatment decisions, and monitor response to disease-modifying agents. Several recent studies in neurodegenerative diseases have demonstrated the feasibility of digital symptom monitoring.

Objective
The aim of this study was to evaluate a novel smartwatch- and smartphone-based digital monitoring platform to remotely monitor signs and symptoms of HD.

Methods
This analysis aimed to determine the feasibility and reliability of the Roche HD Digital Monitoring Platform over a 4-week period and cross-sectional validity over a 2-week interval. Key criteria assessed were feasibility, evaluated by adherence and quality control failure rates; test-retest reliability; known-groups validity; and convergent validity of sensor-based measures with existing clinical measures. Data from 3 studies were used: the predrug screening phase of an open-label extension study evaluating tominersen (NCT03342053) and 2 untreated cohorts—the HD Natural History Study (NCT03664804) and the Digital-HD study. Across these studies, controls (n=20) and individuals with premanifest (n=20) or manifest (n=179) HD completed 6 motor and 2 cognitive tests at home and in the clinic.

Results
Participants in the open-label extension study, the HD Natural History Study, and the Digital-HD study completed 89.95% (1164/1294), 72.01% (2025/2812), and 68.98% (1454/2108) of the active tests, respectively. All sensor-based features showed good to excellent test-retest reliability (intraclass correlation coefficient 0.89-0.98) and generally low quality control failure rates. Good overall convergent validity of sensor-derived features to Unified HD Rating Scale outcomes and good overall known-groups validity among controls, premanifest, and manifest participants were observed. Among participants with manifest HD, the digital cognitive tests demonstrated the strongest correlations with analogous in-clinic tests (Pearson correlation coefficient 0.79-0.90).

Conclusions
These results show the potential of the HD Digital Monitoring Platform to provide reliable, valid, continuous remote monitoring of HD symptoms, facilitating the evaluation of novel treatments and enhanced clinical monitoring and care for individuals with HD.
mHealth Technology Design and Evaluation for Early Childhood Health Promotion: Systematic Literature Review
Authors: DeWitt Akeiylah , Kientz Julie , Coker Tumaini R , Liljenquist Kendra 
Published: June 2022

Background
Recent increases in smartphone ownership among underserved populations have inspired researchers in medicine, computing, and health informatics to design and evaluate mobile health (mHealth) interventions, specifically for those supporting child development and growth. Although these interventions demonstrate possible effectiveness at larger scales, few of these interventions are evaluated to address racial disparities and health equity, which are known factors that affect relevance, uptake, and adherence in target populations.

Objective
In this study, we aimed to identify and document the current design and evaluation practices of mHealth technologies that promote early childhood health, with a specific focus on opportunities for those processes to address health disparities and health equity.

Methods
We completed a systematic literature review of studies that design and evaluate mHealth interventions for early childhood health promotion. We then analyzed these studies to identify opportunities to address racial disparities in early- and late-stage processes and to understand the potential efficacy of these interventions.

Results
Across the literature from medical, computing, and health informatics fields, we identified 15 articles that presented a design or evaluation of a parent-facing health intervention. We found that using mobile-based systems to deliver health interventions was generally well accepted by parents of children aged <5 years. We also found that, when measured, parenting knowledge of early childhood health topics and confidence to engage in health-promoting behaviors improved. Design and evaluation methods held internal consistency within disciplines (eg, experimental study designs were the most prevalent in medical literature, while computing researchers used user-centered design methods in computing fields). However, there is little consistency in design or evaluation methods across fields.

Conclusions
To support more interventions with a comprehensive design and evaluation process, we recommend attention to design at the intervention (eg, reporting content sources) and system level; interdisciplinary collaboration in early childhood health intervention development can lead to large-scale deployment and success among populations.

Trial Registration
PROSPERO CRD42022359797; https://tinyurl.com/586nx9a2
Pengaruh Pendekatan Saintifik Terhadap Keterampilan Komunikasi Dan Pemahaman Konsep Materi Pencemaran Lingkungan
Authors: Ridzal Dewi Asriani , Rosnawati Veni , Haswan Haswan , Kaharudin La Ode , Ridwan Ridwan , Yandi Yandi 
Published: June 2022

The quality of science learning in the science field is still low. This study aims to determine the effect of the scientific approach on students' communication skills and understanding of concepts related to pollution materials. This type of research is a quasi-experimental design with a pretest-posttest design with only control groups. The study population consisted of all seventh-grade students at the SMP Negeri 9 Buton enrolled in the even-numbered semester of the 2021/2022 academic year. The study sample consisted of 45 students. The sampling technique was simple random sampling. A multiple-choice test served as an instrument for examining the communication skills and understanding of the students' concepts. Research data is analyzed descriptively and inferentially. The results showed that a scientific approach had a positive and significant impact on students' communication skills and understanding of pollution concepts.

Key words: Scientific approach, Communication skills, Understanding of concept

Abstrak

Mutu pembelajaran IPA pada bidang sains masih rendah. Penelitian ini bertujuan untuk mengetahui pengaruh pendekatan saintifik terhadap keterampilan komunikasi dan pemahaman konsep siswa pada materi pencemaran lingkungan. Jenis penelitian ini adalah quasi eksperimen dengan desain pretes-postest only control group design. Populasi penelitian adalah seluruh siswa kelas VII SMP Negeri 9 Buton yang terdaftar pada semester genap tahun ajaran 2021/2022. Sampel penelitian berjumlah 45 siswa. Teknik pengambilan sampel adalah simple random sampling. Instrument penelitian keterampilan komunikasi dan pemahaman konsep siswa yang digunakan berupa tes dalam bentuk pilihan ganda. Data hasil penelitian diolah secara deskriptif dan inferensial. Hasil penelitian menunjukan bahwa terdapat pendekatan saintifik berpengaruh positif dan signifikan terhadap keterampilan komunikasi dan pemahaman konsep siswa materi pencemaran lingkungan.

Kata kunci: Pendekatan saintifik, Keterampilan komunikasi, Pemahaman konsep
Tratamientos pregerminativos y germinación de semillas de Vochysia lehmannii en los llanos orientales de Colombia
Authors: Narvaez Ortiz Ildefonso , Torres-Cubides Leonela , Granados González Zoleidy , Delgado-Vargas Iván 
Published: June 2022

Contextualización: Vochysia lehmannii es una especie forestal nativa y de importancia ecológica en las sabanas orientales de Colombia, es utilizada con fines de ornamentación, madera, sus semillas tienen usos alimenticios y medicinales.
Vacío de conocimiento: principalmente crece de manera silvestre debido a la falta de conocimiento científico sobre su germinación, particularmente acerca de la sincronía y factores ambientales que la influyen.
Propósito: en este trabajo se evalúan tratamientos disponibles en la región para identificar el que logre mayor porcentaje de germinación de forma sincrónica.
Metodología: En la Vereda La Peral del Municipio de Paz de Ariporo, Casanare, Colombia se estableció un diseño experimental con dos factores: sustrato y tratamientos pregerminativos. Como sustratos se utilizó tierra abonada y arena de río, y como tratamientos pregerminativos: lijado, corte e inmersión en agua caliente.
Resultados y conclusiones: se obtuvo el mayor porcentaje de germinación y menor tiempo de latencia de 80% y 7 respectivamente como utilizando tierra abonada y corte de la semilla con diferencias significativas (P<0,01) de los demás tratamientos, sin embargo, persiste asincronía en la germinación.