bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive impairment in asymptomatic cerebral arterial stenosis: a P300 study
Authors: Nahas Nevine El , Zaki Amr , Zakaria Magd , Naser Azza Abd El , Bassiony Ahmed El , Abdeldayem Eman , Shokri Hossam , Bokl Ahmed El 
Published: October 2022

Abstract
Background
Cerebral
arterial stenosis (CAS), in the absence of a structural lesion, can result in cognitive impairment that represents an ongoing contention among studies. Accordingly, we investigated cognitive functions in asymptomatic patients with CAS, using P300 which is a neurophysiological tool. We also compared cognition in intracranial stenosis (ICS) and extracranial stenosis (ECS).

Methods
Asymptomatic patients with CAS (≥ 70%) in the absence of structural brain lesions were categorized into ICS and ECS groups of 15 patients each, in addition to 15 normal controls. MRI, MRA, CT angiography, P300 analysis, Mini-Mental State examination (MMSE), Wisconsin Card Sorting Test (WCST), and Wechsler Memory Scale Test-Revised (WMST) were performed to all patients.

Results
Impairment on all cognitive scales ranged from 70 up to 100% among CAS group. Prolonged p300 latency and reaction time correlated with worse performance on WMST (p = 0.02), while lower amplitude and decreased accuracy correlated with more errors on WCST (p = 0.01). ICS scores on WCTS were lower than those of ECS group (p = 0.001), while ECS had a longer reaction time (p = 0.02) and lower scores on MMS and WMST than those of ICS group (p = 0.03).

Conclusion
Patients with asymptomatic CAS had a high prevalence of cognitive dysfunction which places them at risk of higher morbidity. ICS group showed impairment on executive functions, while the ECS group showed predilection to memory and information processing dysfunction.
Gandhi’s Concept of Conscience/Antarātmā Revisited: Exploring His Cardinal Principle in Trilingual Texts
Authors: Hazama Eijiro 
Published: October 2022

AbstractThis article explores the nature and genealogy of Mohandas K. Gandhi’s concept of conscience/antarātmā(inner soul/spirit), the cardinal principle of his religious politics. Much previous scholarship, solely relying upon English materials, has explained the nature of Gandhi’s concept of conscience in relation to Western and Christian Protestant traditions. By chronologically examining his lifelong discourse on conscience expressed in English andantarātmāin Gujarati and Hindi writings, this article shows that: (1) Gandhi developed a distinct variant of hybrid thought that was essentially different from the prevalent negative conception of “guilty conscience” in the modern West by integrating ideas of conscience andātmā/ātman; (2) since the notion ofātmāwas intimately related to the ascetic bodily discipline (brahmacarya), Gandhi identified the essence of hissatyāgrahacampaign asātmabaḷ(the force ofātmā) and believed that taking the vow ofbrahmacaryacould enhance one’s vital energy (vīrya); and (3) as Gandhi reached his last years, and the most controversial phase of his intellectual evolution, he developed a new understanding of an inner voice/antarno avājwhose nature was “mystical” (gūḍh), and thereby difficult even for him to articulate in any language.
Analysing mathematical modelling tasks in light of citizenship education using the COVID-19 pandemic as a case study
Authors: Maass Katja , Zehetmeier Stefan , Weihberger Anika , Flößer Katharina 
Published: October 2022

AbstractIn this paper, we discuss the theoretical background of mathematical modelling and its connection to citizenship education. Citizenship education in this context means that young people are equipped with competencies to respond as responsible citizens in situations relevant for society. To outline the connection between mathematical modelling and citizenship education in theory, we discuss the aims of mathematical modelling, modelling competences and the connection between numeracy and modelling. Based on these reflections we present an extended modelling cycle that specifically highlights modelling steps relevant to citizenship education. To show how the theoretical connection between mathematical modelling and citizenship education can be used in teaching practice, we describe three different examples of modelling tasks and analyse them with the help of the extended modelling cycle. We argue that the three tasks support different learning aims in relation to citizenship education and require modellers to carry out different steps of the extended modelling cycle. As an example of context, we used the pandemic caused by COVID-19, as it affected the quality of human life greatly, as all students in the Western world experienced.
The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases
Authors: Liu Na , Lin Miao-Miao , Wang Yan 
Published: October 2022

AbstractDespite annual increases in the incidence and prevalence of neurodegenerative diseases, there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) have been observed to participate in the pathogenesis mechanisms of neurodegenerative diseases, on the basis of which we conducted a systematic literature review of the studies. This review will help to explore promising therapeutic targets from highly dynamic ubiquitination modification processes.
Reduction of SARS-CoV-2 viral load in exhaled air by antiseptic chewing gum: a pilot trial
Authors: Pfab F. , Buelow-Johansen B. , Alber D. , Kriner M. , Kornmann O. , Stuermer M. 
Published: October 2022

Abstract
Purpose
The dominant route of transmission of SARS-CoV-2 is airborne, through respiratory transmission by aerosols or droplets which can be measured by viral load in exhaled air. Several natural substances have shown antiviral activity. The aim of this pilot study was to investigate the effect of a chewing gum containing natural antiseptic ingredients (cinnamon-, peppermint- and lemon-oil, quercetin, spermidine, ginger and ginseng) on viral load in exhalative air in patients infected with SARS-CoV-2.

Methods
Nine patients infected with SARS-CoV-2 were enrolled and exhaled forcefully into a special mouthpiece at different time points before and after chewing the antiseptic gum. The mouthpiece contained a filter paper serving for extraction of coronaviruses following real-time PCR to quantify the viral load.

Results and conclusion
Cycle threshold (Ct) values of all patients increased after chewing the gum. The mean difference between the Ct values at baseline (before chewing the antiseptic gum) and time point 30 min (15 min after chewing) was 3.8 ± 2.6; (93% viral load reduction; p = 0.002). Time point 15 min (2.7 ± 1.7 (83% viral load reduction; p = 0.003)), 60 min (3.0 ± 3.4 (88% viral load reduction; p = 0.028)), 90 min (3.7 ± 1.8 (92% viral load reduction; p = 0.004)) and 120 min (3.0 ± 3.7 (91% viral load reduction; p = 0.05)) showed similar results. The antiseptic chewing gum demonstrated a significant potential to reduce SARS-CoV-2 viral load in exhalative air and, in this way, reduce further spread and infection risk. Larger placebo-controlled clinical trials are required to confirm these findings further.
Osteology and neuroanatomy of a phasianid (Aves: Galliformes) from the Miocene of Nebraska
Authors: Ksepka Daniel T. , Early Catherine M. , Dzikiewicz Kate , Balanoff Amy M. 
Published: October 2022

AbstractTetraoninae (grouse) and Meleagridinae (turkeys) are conspicuous representatives of the modern North American avifauna. The pre-Pleistocene fossil record of these clades has historically been limited to fragmentary remains, in some cases contributing to confusion rather than improving our understanding of how these charismatic landfowl evolved. We report an exquisitely preserved partial skeleton representing a new species of Late Miocene phasianid from the Ash Hollow Formation of Nebraska.Centuriavis lioaen. gen. n. sp. is a phasianid species close in size to modern sage-grouse that diverged prior to the grouse-turkey split, and thus offers insight into the early history of this radiation. The cranial endocast resembles other North American phasianids and differs from odontophorids in exhibiting a strongly projected Wulst bordered by a well-defined vallecula. Phylogenetic analyses indicate thatCenturiavis lioaeforms a clade with Tetraoninae, Meleagridinae, andPucrasia macrolopha(Koklass pheasant). The new fossil species provides a Late Miocene minimum calibration for the divergence of these extant taxa from other Galliformes and supports the hypothesis of a single dispersal from Asia to North America by a lineage that later gave rise to grouse and turkeys.UUID:https://zoobank.org/34ecda2f-f2f2-4c92-a82f-292e23cf2da1
Baseline correction for FAST radio recombination lines: A modified penalised least squares smoothing technique
Authors: Liu Bin , Wang Lixin , Wang Junzhi , Peng Bo , Wang Hongjun 
Published: October 2022

Abstract
A pilot project has been proceeded to map

$1\, \textrm{deg}^2$

on the Galactic plane for radio recombination lines (RRLs) using the Five-hundred-metre Aperture Spherical Telescope (FAST). The motivation is to verify the techniques and reliabilities for a large-scale Galactic plane RRL survey with FAST aiming to investigate the ionised environment in the Galaxy. The data shows that the bandpass of the FAST 19 beam L-band is severely affected by radio frequency interferences and standing wave ripples, which can hardly be corrected by traditional low order polynomials. In this paper, we investigate a series of penalised least square (PLS) based baseline correction methods for radio astronomical spectra that usually contain weak signals with high level of noise. Three promising penalised least squares based methods, AsLS, arPLS, and asPLS are evaluated. Adopting their advantages, a modified method named rrlPLS is developed to optimise the baseline fitting to our RRL spectra. To check their effectiveness, the four methods are tested by simulations and further verified using observed data sets. It turns out that the rrlPLS method, with optimised parameter

$\lambda=2\times10^8$

, reveals the most sensitive and reliable emission features in the RRL map. By injecting artificial line profiles into the real data cube, a further evaluation of profile distortion is conducted for rrlPLS. Comparing to simulated signals, the processed lines with low signal-to-noise ratio are less affected, of which the uncertainties are mainly caused by the rms noise. The rrlPLS method will be applied for baseline correction in future data processing pipeline of FAST RRL survey. Configured with proper parameters, the rrlPLS technique verified in this work may also be used for other spectroscopy projects.
Associations between breast milk intake volume, macronutrient intake and infant growth in a longitudinal birth cohort: the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF)
Authors: Olga Laurentya , Vervoort Jacques , van Diepen Janna A. , Gross Gabriele , Petry Clive J. , Prentice Philippa M. , Chichlowski Maciej , van Tol Eric A. F. , Hughes Ieuan A. , Dunger David B. , Ong Ken K. 
Published: October 2022

AbstractGrowth patterns of breastfed infants show substantial inter-individual differences, partly influenced by breast milk (BM) nutritional composition. However, BM nutritional composition does not accurately indicate BM nutrient intakes. This study aimed to examine the associations between both BM intake volumes and macronutrient intakes with infant growth. Mother–infant dyads (n 94) were recruited into the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF) from a single maternity hospital at birth; all infants received exclusive breast-feeding (EBF) for at least 6 weeks. Infant weight, length and skinfolds thicknesses (adiposity) were repeatedly measured from birth to 12 months. Post-feed BM samples were collected at 6 weeks to measure TAG (fat), lactose (carbohydrate) (both by 1H-NMR) and protein concentrations (Dumas method). BM intake volume was estimated from seventy infants between 4 and 6 weeks using dose-to-the-mother deuterium oxide (2H2O) turnover. In the full cohort and among sixty infants who received EBF for 3+ months, higher BM intake at 6 weeks was associated with initial faster growth between 0 and 6 weeks (β + se 3·58 + 0·47 for weight and 4·53 + 0·6 for adiposity gains, both P < 0·0001) but subsequent slower growth between 3 and 12 months (β + se − 2·27 + 0·7 for weight and −2·65 + 0·69 for adiposity gains, both P < 0·005). BM carbohydrate and protein intakes at 4–6 weeks were positively associated with early (0–6 weeks) but tended to be negatively related with later (3–12 months) adiposity gains, while BM fat intake showed no association, suggesting that carbohydrate and protein intakes may have more functional relevance to later infant growth and adiposity.
The effect of spraying bacterial and fungal solutions on Korean pine Pinus koraiensis Sieb. et Zucc. cone development and seed quality when sprayed during the flowering phase
Authors: Wang Xiaomei , Chen Ruting , Jia Niya , Sun Jiaxing , Luo Yuxin , Yang Yunzhao , Zhuang Yutong , Wang Jingfeng , Guo Hongru , Chi Defu 
Published: October 2022

AbstractKorean pine is an economically essential afforestation species limited by the unreasonable collection of cones, indiscriminate use of chemical pesticides and pest damage. This study aimed to determine whether spraying bacterial or fungal solutions affected insect pests, cone development, and the seed quality of Korean pine Pinus koraiensis Sieb. et Zucc. The experiment was conducted in a forest plantation in Linkou County (Heilongjiang, China) in 2019. Four fungal strains and one bacterial strain were applied during the flowering phase of Korean pine. The results after a year and a half of study indicated that a high concentration of Bacillus thuringiensis 223176 promoted cone development, increased seed weight, and reduced the proportion of damaged cones. Under this treatment, there were 15.873% damaged cones; the seed weight reached 0.829 g, and there were 82.738% fully developed cones. Trees treated with the second most effective strain, Beauveria bassiana 122077, had 30.556% damaged cones and an average seed weight of 0.810 g. Leucanicillium antillanum 01 performed the worst in this study. The seed weight was only 0.775 g, and the damaged and fully developed cones were 52.444 and 41.773%, respectively. In summary, spraying bacterial or fungal solutions during the flowering stage of Korean pine positively impacted seed quality and effectively decreased damage by the lepidopteran species that feed on the cones and seeds in this study.
A molecular characterization of marsupial filarioid nematodes of the genusBreinlia
Authors: Koehler Anson V. , Beveridge Ian , Spratt David M. 
Published: October 2022

AbstractHere we present the genetic relationships of 26 specimens of the genusBreinlia(Nematoda: Filarioidea) from a range of Australian marsupials using markers in the small subunit of nuclear ribosomal RNA and mitochondrial cytochromecoxidase subunit 1 (cox1) genes and compare them with morphological determinations. The molecular data support the validity of most of the morpho-species included in the study and provide provisional insights into the phylogeny of the genus in Australian mammals, with dasyuroid marsupials appearing to be the original hosts. The recent discovery ofBreinlia annulipapillatain the eye of a human brings this genus of parasites into the group of emerging infectious parasitic diseases.
A close fitt: reading Beowulf fitt II with the Andreas-poet
Authors: Thomas Daniel 
Published: October 2022

AbstractConnections between Andreas and Beowulf have been the subject of much scholarly discussion. This article contributes to this discussion by arguing that the account of the Mermedonians’ discovery of and response to the loss of their prisoners in Andreas fitt X, which corresponds to chapters 22–3 of the poet’s putative Latin source, has been deliberately recast in ways intended to recall the account in fitt II of Beowulf of Grendel’s first attack on Heorot and the reactions of the Danish community. The connection argued for here is based not on verbal correspondences, but on embedded structural and thematic parallels. The Andreas-poet emerges as a careful and sophisticated reader, notable for their specifically literate and textual engagement with Beowulf. This observation has implications not only for our appreciation of the Andreas-poet’s art, but also for the transmission of Beowulf and for our understanding of Old English poetic practices more generally.
Is native aortic valvuloplasty at time of Norwood operation in infants with hypoplastic left heart syndrome and aortic stenosis safe?
Authors: Segar David E. , Frommelt Peter C. , Woods Ronald K. 
Published: October 2022

AbstractIn hypoplastic left heart syndrome, the size and function of the left ventricle vary and are dependent on the patency of the aortic valve. A patent native aortic valve, permitting left ventricular ejection, can augment cardiac output. We performed a retrospective chart review of patients with hypoplastic left heart syndrome and a stenotic aortic valve who underwent native aortic valvuloplasty at the time of Norwood and found that none of the eight patients identified had clinically significant aortic insufficiency. This case series suggests that surgical aortic valvuloplasty at Norwood is associated with aortic valve patency/augmented systemic cardiac output without the development of clinically significant aortic regurgitation at intermediate follow-up in a limited cohort.
Middle to Late Holocene Sea Surface Temperature and Productivity Changes in the Northeast Pacific
Authors: Cheung Anson H. , Sandwick Samantha , Du Xiaojing , Abella‐Gutiérrez Jose , Vachula Richard S. , Herbert Timothy D. , Fox‐Kemper Baylor , Herguera Juan Carlos 
Published: October 2022

AbstractVariations of the sea surface temperature (SST) and primary productivity in the northeast Pacific have far‐reaching implications. In addition to influencing the regional and global temperature and hydroclimate, these conditions also control marine ecosystems and their services, which subsequently impact regional economies. Yet, our understanding of the variability and controls of northeast Pacific SST and productivity on timescales exceeding observational records remains limited. Here, we use marine sediment records from seven locations, spanning 25.2°N–59.6°N, in the northeast Pacific to characterize the millennial‐scale variability of SST and productivity from 9,000 to 1,000 years BP. We explore the dynamics of their spatiotemporal evolution and compare these data with transient climate model outputs to identify potential drivers. Through a heat budget analysis and optimal fingerprinting analysis, we characterize the spatial pattern of forcings. We find that SST varied spatially in the northeast Pacific, with higher latitudes exhibiting greater magnitude changes than lower latitudes, which differs from previous work suggesting regional synchronicity and coherence during the Holocene. Our analysis did not find evidence for coherent variability of primary producer community nor carbon export, highlighting the difficulty of identifying the complex interactions between environmental conditions, producers, and carbon export. Model‐proxy disagreement demonstrates the need for higher resolution model frameworks, but shows nonetheless that observed variability in the proxy records can be explained by a combination of greenhouse gas and orbital forcing. We suggest that the complex SST variations and marine ecosystem responses to forced changes are important factors that can drive disagreements in model projections.
Slope and Shelf Flow Anomalies Off Oregon Influenced by the El Niño Remote Oceanic Mechanism in 2014–2016
Authors: Kurapov Alexander L. , Rudnick Daniel L. , Cervantes Brandy T. , Risien Craig M. 
Published: October 2022

AbstractOutputs of the regional ocean circulation model are analyzed to demonstrate the measurable impact of the El Niño remote oceanic forcing mechanism along the US West Coast during the major heat wave period of 2014–2016. The 2‐km horizontal resolution model, based on the Regional Ocean Modeling System (ROMS), was run for the period of 2009–2018. Though the model does not assimilate observations, it performs well by comparison with time series data explaining observed variability on temporal scales from several days to seasonal and interannual. The El Niño‐related oceanic anomalies provided by a global state estimate are introduced in the regional model at the southern boundary at 24N. These propagate alongshore with coastally trapped waves (CTWs) and influence the variability off Oregon (41°–46°N). In particular, CTWs are evident in the subsurface along‐slope current, vs, and in the depth of the 26.5 kg m−3 isopycnal surface over the slope, z26.5. In summer 2014 and 2015, vs anomalies are positive (northward) and z26.5 anomalies are negative (deeper) along the US West Coast. In addition to the CTW patterns, z26.5 anomalies also exhibit slow‐moving features associated with undercurrent widening, separation, and subsurface eddy variability. Over the Oregon shelf, El Niño conditions contributed to the sharp weakening of the southward alongshore current throughout the water column in July 2014 and 2015, despite the near‐average southward, upwelling‐favorable winds.
Light People: Professor Guangming Tao
Authors: Wang Hui 
Published: October 2022

Editorial‘In the short but hot summer nights, only by opening doors and windows can the room be cooled down slightly’ complained the famous Chinese poet Fu Du in his poem Summer Night Lament more than 1000 years ago. Currently, people are suffering from the summer heat, with ambient temperatures around or exceeding 40 °C. Phrases such as “killer hot days” are no longer exaggerated statements. Hot weather can not only frustrate people, but also make people sick or even endanger lives owing to heatstroke. Fortunately, scientists have come up with a great invention, which will provide us with some much-needed relief in hot summers—the optical metafabric. The magic of this innovation is that, although it feels just like a normal fabric and has all the necessary properties of a wearable fabric, a garment made with it can cool down one’s body by nearly 5 °C even under direct sunlight, making it ideal for summer clothing. In the last few years, a team led by Prof. Guangming Tao of Huazhong University of Science and Technology has achieved remarkable progress in the area of optical metafabrics, finding new applications for this material and making it more affordable. Now, please follow our Light Science Editor as he explores this amazing new material and finds how it has been used in the industry, society, and Winter Olympics.