bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wiedza i postawy mieszkańców gminy Czaplinek w zakresie profilaktyki raka jelita grubego
Authors: Jaroszyńska Zuzanna , Andrusiewicz Mirosław , Wiśniewska Katarzyna 
Published: January 2022

Wprowadzenie i cel: Rak jelita grubego (C18-C21) stanowi obecnie w Polsce drugą wśród mężczyzn i trzecią wśród kobiet przyczynę zgonów nowotworowych. Celem pracy była ocena wiedzy oraz postaw mieszkańców gminy Czaplinek w zakresie profilaktyki raka jelita grubego.
Materiał i metoda: Badanie przeprowadzono w okresie od października do grudnia 2020 roku wśród 238 mieszkańców gminy Czaplinek, położonej w województwie zachodniopomorskim, w powiecie drawskim. Narzędzie badawcze stanowił autorski kwestionariusz ankiety, składający się z 22 pytań o charakterze zamkniętym. Otrzymane wyniki opracowano w arkuszu kalkulacyjnym Microsoft® Excel® 2016 MSO i poddano analizie statystycznej przy użyciu oprogramowania Statistica® (TIBCO Software Inc.).
Wyniki: Przeważająca część ankietowanych (74,8%) wiedziała, że wczesne zdiagnozowanie raka jelita grubego znacząco zwiększa szanse na jego wyleczenie. Tylko połowa respondentów (50,8%) miała świadomość tego, że nowotwór ten może rozwijać się bezobjawowo. Znajomość czynników ryzyka oraz objawów raka jelita grubego w grupie badanej była niska. Ogólny poziom wiedzy respondentów na temat raka jelita grubego i jego profilaktyki był najczęściej dostateczny (62,5%). Niespełna jedna trzecia ankietowanych (31,5%) słyszała o Programie Badań Przesiewowych raka jelita grubego.
Wnioski: Poziom wiedzy oraz postaw mieszkańców gminy Czaplinek w zakresie raka jelita grubego i jego profilaktyki jest zdecydowanie niezadowalający. Istnieje pilna potrzeba prowadzenia intensywnych działań edukacyjnych, skupiających się przede wszystkim na promowaniu badań przesiewowych w kierunku raka jelita grubego.
Green to Gone? Regional Institutional Logics and Firm Survival in Moral Markets
Authors: Vedula Siddharth , York Jeffrey G. , Conger Michael , Embry Elizabeth 
Published: January 2022

A growing body of scholarship studies the emergence of moral markets—sectors offering market-based solutions to social and environmental issues. To date, researchers have largely focused on the drivers of firm entry into these values-laden sectors. However, we know comparatively little about postentry dynamics or the determinants of firm survival in moral markets. This study examines how regional institutional logics—spatially bound, socially constructed meaning systems that legitimize specific practices and goals within a community—shape firm survival in emerging moral markets. Using a unique panel of firms entering the first eight years of the U.S. green building supply industry, we find that (1) a regional market logic amplifies the impacts of market forces by increasing the positive impact of market adoption and the negative impact of localized competition on firm survival, (2) a regional proenvironmental logic dampens the impacts of adoption and competition on firm survival, and (3) institutional complexity—the co-occurrence of both market and proenvironmental logics in a region—negates the traditional advantages of de alio (diversifying incumbent) firms, creating an opportunity for de novo (entrepreneurial entrant) firms to compete more effectively. Our study integrates research on industry emergence, institutional logics, and firm survival to address important gaps in our knowledge regarding the evolution and growth of environmental entrepreneurship in moral markets.Funding: J. G. York thankfully acknowledges support from the Michael and Sherri Miske Faculty Research Award given by the Leeds School of Business, University of Colorado, Boulder.
Shared genetic liability between major depressive disorder and osteoarthritis
Authors: Zhang Fuquan , Rao Shuquan , Baranova Ancha 
Published: January 2022

AimsDeciphering the genetic relationships between major depressive disorder (MDD) and osteoarthritis (OA) may facilitate an understanding of their biological mechanisms, as well as inform more effective treatment regimens. We aim to investigate the mechanisms underlying relationships between MDD and OA in the context of common genetic variations.MethodsLinkage disequilibrium score regression was used to test the genetic correlation between MDD and OA. Polygenic analysis was performed to estimate shared genetic variations between the two diseases. Two-sample bidirectional Mendelian randomization analysis was used to investigate causal relationships between MDD and OA. Genomic loci shared between MDD and OA were identified using cross-trait meta-analysis. Fine-mapping of transcriptome-wide associations was used to prioritize putatively causal genes for the two diseases.ResultsMDD has a significant genetic correlation with OA (rg= 0.29) and the two diseases share a considerable proportion of causal variants. Mendelian randomization analysis indicates that genetic liability to MDD has a causal effect on OA (bxy= 0.24) and genetic liability to OA conferred a causal effect on MDD (bxy= 0.20). Cross-trait meta-analyses identified 29 shared genomic loci between MDD and OA. Together with fine-mapping of transcriptome-wide association signals, our results suggest that Estrogen Receptor 1 ( ESR1), SRY-Box Transcription Factor 5 ( SOX5), and Glutathione Peroxidase 1 ( GPX1) may have therapeutic implications for both MDD and OA.ConclusionThe study reveals substantial shared genetic liability between MDD and OA, which may confer risk for one another. Our findings provide a novel insight into phenotypic relationships between MDD and OA. Cite this article: Bone Joint Res 2022;11(1):12–22.
Changing Caribbean geographies: connections in flora, fauna and patterns of settlement from Indian inheritances
Authors: Samaroo Brinsley 
Published: January 2022

There can be no doubt that Indian immigration to the plantation colonies changed the geography of those colonies. However, most analyses have dealt with the sugar industry in the colonies after the abolition of slavery. This paper will argue that, apart from the sugar industry, Indian labour and ingenuity made other significant contributions to plantation economies. The girmityas (agreement signers) were well aware that they were going to agricultural occupations so they took with them an amazing array of dried fruits, seeds and cuttings, which survived the long crossing, adding to the flora of the plantations. Armed with this foreknowledge, the jahajis packed these items into their jahaji bundles alongside the Tulsi Ramayan and the Holy Qu'ran. Animals too formed part of this international trade. Sheep, goats and poultry which were not eaten on the outward voyage were sent to the estates, where they multiplied. When dangerous snakes threatened plantation security, cages of mongoose were dispatched to the Caribbean where they bravely tackled venomous creatures. At the urging of Indian labourers with long experience in the sugar industry, the plantations' owners imported Brahma bulls and Zebu cattle, which revolutionised transport on the estates and provided leather, manure and meat to the wider population.
There is also the amazing story of the importation of hundreds of water buffaloes (bhaisa) from the Indo-Gangetic plains. Some nine breeds were imported and in the twentieth century Caribbean bio-geneticists were able to blend the best qualities of those Indian animals and created a new hybrid, the buffalypso, which combined the scientific name with Trinidad's fame as the land of the calypso. The buffalypso became a prized animal for haulage, meat, milk and leather and an item of export to Venezuela, Colombia, Miami and the wider Caribbean. Indian cultivars were continuously exported to the botanic gardens in the Caribbean and Indian forestry experts were sent to the region to advise on forest rehabilitation in the wake of large-scale deforestation, which sugar cultivation required. In these and other ways the physical character of the Caribbean underwent permanent change, which manifests itself today.
Ventas disimuladas de oficios, granjerías y corruptelas en el Estado de Brasil a inicios del siglo XVII. Prácticas sociales y límites del poder real
Authors: Santos Pérez José Manuel 
Published: January 2022

La puesta en marcha de una serie de reformas en diversos ámbitos, destacando la Hacienda, en el territorio de la América portuguesa durante las décadas iniciales del siglo xvii, chocó con una realidad colonial complicada. Obstáculos sociales, políticos y mentales junto con las contradicciones de la política real, condujeron al fracaso del plan reformista y al mantenimiento de prácticas como la venta disimulada de oficios o el abuso en el cobro de granjerías, consideradas «corruptelas» por algunos oficiales.
Palabras clave: Brasil, unión ibérica, venalidad, corrupción, reformas.
Sarcopenia assessed by 4-step EWGSOP2 in elderly hemodialysis patients: Feasibility and limitations
Authors: Sánchez-Tocino M. Luz , Miranda-Serrano Blanca , Gracia-Iguacel Carolina , de-Alba-Peñaranda Ana María , Mas-Fontao Sebastian , López-González Antonio , Villoria-González Silvia , Pereira-García Mónica , Ortíz Alberto , González-Parra Emilio 
Published: January 2022

Background
In 2019, EWGSOP2 proposed 4 steps to diagnose and assess sarcopenia. We aimed to quantify the prevalence of sarcopenia according to the EWGSOP2 diagnostic algorithm and to assess its applicability in elderly patients on hemodialysis.

Methods
Prospective study of 60 outpatients on chronic hemodialysis aged 75- to 95-years, sarcopenia was assessed according to the 4-step EWGSOP2: Find: Strength, Assistance walking, Rise from a chair, Climb stairs, and Falls (SARC-F); Assess: grip strength by dynamometry (GSD) and sit to stand to sit 5 (STS5); Confirm: appendicular skeletal muscle mass (ASM) by bioimpedance; Severity: gait speed (GS), Timed-Up and Go (TUG), and Short Physical Performance Battery (SPPB).

Results
The sequential four steps resulted in a prevalence of confirmed or severe sarcopenia of 20%. Most (97%) patients fulfilled at least one criterion for probable sarcopenia. The sensitivity of SARC-F for confirmed sarcopenia was low (46%). Skipping the SARC-F step increased the prevalence of confirmed and severe sarcopenia to 40% and 37%, respectively. However, 78% of all patients had evidence of dynapenia consistent with severe sarcopenia. Muscle mass (ASM) was normal in 60% of patients, while only 25% had normal muscle strength values (GSD).

Conclusions
According to the 4-step EWGSOP2, the prevalence of confirmed or severe sarcopenia was low in elderly hemodialysis patients. The diagnosis of confirmed sarcopenia underestimated the prevalence of dynapenia consistent with severe sarcopenia. Future studies should address whether a 2-step EWGSOP2 assessment (Assess-Severity) is simpler to apply and may provide better prognostic information than 4-step EWGSOP2 in elderly persons on hemodialysis.
The risk of fatal bleeding complications in jugular catheterization in patients with coagulopathy: A retrospective analysis of death cases in closed claims and the Medical Accident Investigating System in Japan
Authors: Otaki Yasuhiro , Fujishiro Naofumi , Oyama Yasuaki , Hata Naoko , Kato Daisuke , Kawachi Shoji 
Published: January 2022

BackgroundTo prevent recurrence of medical accidents, the Medical Accident Investigating System was implemented in October 2015 by the Japan Medical Safety Research Organization (Medsafe Japan) to target deaths from medical care that were unforeseen by the administrator. Medsafe Japan analyzed the 10 cases of central venous catheterization-related deaths reported in the system and published recommendations in March 2017. However, the particular emphasis for the prevention of central venous catheterization-related deaths is unclear.MethodsThis study aimed to identify the recommendation points that should be emphasized to prevent recurrence of central venous catheterization-related deaths. We assessed central venous catheterization in 8530 closed-claim cases between January 2002 and December 2016 covered by the medical insurer Sompo-Japan. Moreover, we compared central venous catheterization-related death in closed-claim cases with death in reported cases.ResultsThe background, error type, anatomic insertion site, and fatal complication data were evaluated for 37 closed-claim cases, of which 12 (32.4%) were death cases. Of the 12 closed-claim cases and 10 reported cases, 9 (75.0%) closed-claim cases and 9 (90.0%) reported cases were related to vascular access. Among these, 5 closed-claim cases (41.7%) and 7 reported cases (77.8%) were related to internal jugular vein catheterization (p = 0.28). Coagulopathy was observed in 3 (60.0%) of 5 closed-claim cases and 6 (85.7%) of 7 reported cases.ConclusionsThe risk of internal jugular catheterization in patients with coagulopathy must be carefully considered.
Prospective evaluation of percutaneous hepatic perfusion with melphalan as a treatment for unresectable liver metastases from colorectal cancer
Authors: Meijer T. Susanna , Dieters Jan H. N. , de Leede Eleonora M. , de Geus-Oei Lioe-Fee , Vuijk Jaap , Martini Christian H. , van Erkel Arian R. , Lutjeboer Jacob , van der Meer Rutger W. , Tijl Fred G. J. , Kapiteijn Ellen , Vahrmeijer Alexander L. , Burgmans Mark C. 
Published: January 2022

Purpose
Percutaneous hepatic perfusion with melphalan (M-PHP) is increasingly used in patients with liver metastases from various primary tumors, yet data on colorectal liver metastases (CRLM) are limited. The aim of this study was to prospectively evaluate the efficacy and safety of M-PHP in patients with CRLM.

Materials and methods
Prospective, single-center, single-arm phase II study of M-PHP with hemofiltration in patients with unresectable CRLM. Proven, extrahepatic metastatic disease was one of the exclusion criteria. Primary outcomes were overall response rate (ORR) and best overall response (BOR). Secondary outcomes were overall survival (OS), progression-free survival (PFS), hepatic PFS (hPFS), and safety.

Results
A total of 14 M-PHP procedures were performed in eight patients between March 2014 and December 2015. All patients (median age 56 years, ranging from 46 to 68) had received (extensive) systemic chemotherapy before entering the study. The ORR was 25.0%, with two out of eight patients showing partial response as BOR. Median OS was 17.3 months (ranging from 2.6 to 30.9) with a one-year OS of 50.0%. Median PFS and hPFS were 4.4 and 4.5 months, respectively. No serious adverse events occurred. Grade 3/4 hematologic adverse events were observed in the majority of patients, though all were transient and well-manageable.

Conclusion
M-PHP is a safe procedure with only limited efficacy in patients with unresectable CRLM who already showed progression of disease after receiving one or more systemic treatment regimens.
Development of iron ores sintering machine for blast furnace process
Authors: Akinfolarin Femi , Kareem Buliaminu , Alabi Oladunni Oyetola 
Published: January 2022

There must be proper means to sinter and, agglomerated iron ore
concentrate before it can be further processed in the blast furnace. A
Sintering machine of 5kg capacity of agglomerated ore was designed and
fabricated using mild steel material, which was locally sourced. The
machine was fabricated with a combustion chamber of 30 by 30 cm and with
15cm depth. It was also lined with refractory material to reduce the
chamber to the volume of 3375 cm3. However, the sintering chamber was
designed to have a truncated square pyramid shape to the volume of 2150 cm3
after lining with refractory material. The design was made to utilize coke
and palm kernel shell char as fuel which will be ignited to produce heat
into the sintered material by suction of the heat into the agglomerated
sintered ore. Tests such as tumbler index, abrasion, and porosity test were
carried out on the sintered products in agreement with ASTM E276 and E389
standards. The results from the test gave a tumbler index of 70.2% and
65.7% for coke and palm kernel shells respectively. Also, abrasion index of
5.1% and 4.6% for coke and palm kernel char, and porosity of 6.8% and 6.5%
for coke and palm kernel char respectively. The results from the
experimental test were in agreement with other research work. Therefore,
the developed iron ore sintering machine has a better efficiency of
producing sinter for blast furnace operation.
One Obstacle among Many: The Filibuster and Majority Party Agendas
Authors: Curry James M. , Lee Frances E. 
Published: January 2022

Abstract
In today’s hyper-partisan environment, scholars and commentators contend that the filibuster poses a nearly insuperable obstacle to a Senate majority party’s agenda, limiting Congress’s output to non-controversial measures. Drawing on data about congressional majority party agenda priorities from 1985 to 2020 we identify when and how majority party legislative efforts fell short of success and take stock of the degree to which the filibuster was the primary culprit. Not surprisingly, our data confirm that the filibuster is a significant problem for majority party agendas. But an even more common cause of failure is the majority party’s inability to agree among themselves. Despite increased voting cohesion generally, parties in the polarized era still routinely struggle to bridge their own internal divides.
Theological Wiggle Room as a Resource in Ordinary Theology: Significance for Ecclesiology, Leadership, and Personal Development
Authors: Tveitereid Knut , Norheim Bård 
Published: January 2022

Abstract
Ordinary theology is often described as unrefined and imprecise in comparison to academic theology. A recent ethnographic study of vital youth ministries discovered a similar pattern, which the study coined “theological wiggle room.” This article discusses how a lack of precision may serve as a possible resource for theology in the ordinary, and thereby why theological wiggle room may be of significance. The article argues that a certain theological wiggle room engages centripetal and centrifugal dynamics. In other words, the lack of precision should not be interpreted as a shortage or deficiency alone, but as a significant quality of theology in the ordinary – in particular with regard to ecclesiology, leadership and personal development.
Systemic Terror, Silent Mourning, and Postcolonial Hope: The Case of Forcibly Separated Migrant Families
Authors: Ahn Ilsup , Chung Jaeyeon Lucy 
Published: January 2022

Abstract
The purpose of this paper is three-fold. First, it investigates how the historical and structural injustice has to do with the Central American migration crisis in the U. S. Second, this paper explores immense yet largely unrecognized socio-psychological trauma that forcibly separated migrant families, especially children and their parents must endure. Lastly, this paper develops the concept of postcolonial hope as a practical theological response to the Central American migration crisis and the US biopolitical separation of migrant families. The authors argue that postcolonial hope is conceived as people’s resistance against the state’s anti-immigration biopolitics to reckon with the structural sins of dehumanization and terrorization.
Analysis of the anticipated transient without scram (ATWS) initiated by emergency power mode through the full scope simulator
Authors: Soares Alexandre de Souza , Alvim Antonio C. M. 
Published: January 2022

Abstract
The integrity of the reactor coolant system is severely challenged as a result of an Emergency Power Mode – ATWS event. The purpose of this paper is to simulate the Anticipated Transient without Scram (ATWS) using the full scope simulator of Angra 2 Nuclear Power Plant with the Emergency Power Case as a precursor event. The results are discussed and will be used to examine the integrity of the reactor coolant system. In addition, the results were compared with the data presented in Final Safety Analysis Report (FSAR – Angra 2) in order to guarantee the validation of the methodology and from there analyze other precursor events of ATWS which presented only plausibility studies in FSAR – Angra 2. In this way, the aim is to provide and develop the knowledge and skill necessaries for control room operating personnel to ensure safe and reliable plant operation and stimulate information in the nuclear area through the academic training of new engineers. In the presented paper the most severe scenario is analyzed in which the Reactor Coolant System reaches its highest level of coolant pressure. This scenario is initiated by the turbine trip jointly with the loss of electric power systems (Emergency Power Mode). In addition, the failure of the reactor shutdown system occurs, i.e., control rods fail to drop into the reactor core. The reactor power is safely reduced through the inherent reactivity feedback of the moderator and fuel, together with an automatic boron injection. Several operational variables were analyzed and their profiles over time are shown in order to provide data and benchmarking references. At the end of the event, it was noted that Reactor shutdown is assured, as is the maintenance of subcriticality. Residual heat removal is ensured.
Does diabetes affect paraneoplastic thrombocytosis in colorectal cancer?
Authors: Herczeg Gyorgy , Somogyi Aniko , Herold Magdolna , Fodor Agnes , Rosta Klara , Dank Magdolna , Lang Zsolt , Herold Zoltan 
Published: January 2022

Abstract

Background
A large variety of factors can affect colorectal cancer (CRC) survival, including type 2 diabetes mellitus (T2DM) and paraneoplastic thrombocytosis. Although several common factors play a role in their development and platelets are damaged in both diseases, the combined relationship of the three conditions was never investigated previously.

Methods
A prospective, real-life observational cohort study was conducted with the inclusion of 108 CRC patients and 166 voluntary non-CRC subjects. Plasma interleukin-6 and thrombopoietin levels were measured.

Results
Study participants were divided into cohorts based on the presence of T2DM. Platelet count (p < 0.0500) and interleukin-6 (p < 0.0100) level were significantly higher in the CRC groups. Thrombopoietin level was higher in the T2DM, CRC, and CRC + T2DM groups (p < 0.0500). Analysis of parameter changes over time and survival models revealed that neither platelet count, interleukin-6, nor thrombopoietin levels were affected by T2DM. Death of patients was associated with higher baseline platelet count (p = 0.0042) and interleukin-6 level (p < 0.0001).

Conclusion
Although the independent, disease-worsening effect of paraneoplastic thrombocytosis and T2DM is known, the coexistence of the two did not further impair the survival of CRC patients, suggesting that T2DM has no significant effect over paraneoplastic thrombocytosis.
Rotational varifocal moiré metalens made of single-crystal silicon meta-atoms for visible wavelengths
Authors: Ogawa Chikara , Nakamura Sotaro , Aso Takumi , Ikezawa Satoshi , Iwami Kentaro 
Published: January 2022

Abstract
Metasurface lenses (metalenses) offer an ultrathin and simple optical system with dynamic functions that include focal length tuning. In this study, a rotational varifocal (i.e., moiré) metalens based on octagonal single-crystal silicon pillars was designed and fabricated to realize a high transmittance, whole 2π phase coverage, and polarization insensitivity for visible wavelengths. The moiré metalens consists of a pair of cascaded metasurface-based phase lattices and the focal length can be adjusted from negative to positive by mutual rotation. The fabricated moiré metalens demonstrated a focal length that can be tuned from −36 mm to −2 mm and from 2 to 12 mm by mutual rotation from −90° to 90°, and the experimental measurements agreed well with theoretical values at the design wavelength of 633 nm. Imaging was demonstrated at three distinct wavelengths of 633, 532, and 440 nm.