bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navigating “the chaos”: teacher considerations while adapting curriculum and instruction during the COVID-19 pandemic
Authors: Nerlino Erin 
Published: May 2022

PurposeThe pandemic has presented many new challenges tasking teachers with meeting the various social-emotional, academic and logistical needs of students in the midst of an ever-changing landscape. The onset of COVID-19 has drastically impacted schools and inevitably raised questions about nearly all aspects of teaching including but not limited to: how to deliver instruction, grade students, engage students, deliver materials to students, create equitable access to curriculum and assess students' mental and social health in the context of remote, hybrid and in-person instructional models. As such, this paper examines the role that the pandemic plays in deeply complexifying the already intricate decision-making processes that teachers undergo on a daily basis.Design/methodology/approachThis study uses a participant research design (Wagner, 1993) to conduct a ground-level analysis of what two high school English Language arts teachers consider as they adapt curriculum and instruction during the COVID-19 pandemic.FindingsThis study set out to fulfill two aims: (1) to examine teacher considerations during the process of adapting curriculum and instruction and (2) to document the challenges and opportunities teachers face during this process. Findings related to the first aim revolve around teacher considerations of dilemmas such as: individual conferences vs whole class curriculum progress, depth vs breadth in relation to academic progress, social emotional concerns for student well-being vs curricular progress, creating meaningful learning activities and assessments vs COVID-19 limitations, and flexibility and accountability. In addition to navigating these dilemmas, the extreme uncertainty of the situation also prompted findings related to the second aim: opportunities to experiment with new curricular ideas and the challenge of traversing a wide range of teacher emotions.Originality/valueThis paper's qualitative research design that draws on my identities of classroom teacher and doctoral student to provide an original perspective into what teachers experienced in terms of adapting curriculum and instruction during an unprecedented time. While much research, news and media, and policy has discussed the pandemic's impact on education, there is an urgent need for more teacher voices to inform understanding of what occurs on the ground level of classrooms.
Social innovation in South Africa: building inclusive economies?
Authors: Sheik Adelaide , van Rooyen Deidre , Mazzei Micaela 
Published: May 2022

Purpose
Social innovation (SI) acknowledges socio-economic challenges as opportunities to make communities more sustainable and cohesive through inclusive grassroots practices. The question remains, however, as to whether and how socially innovative practices can be effectively supported in developing inclusive economies. Drawing on the findings from two South African in-depth case studies, This paper aims to discuss how social innovation ventures may be supported to drive inclusiveness.

Design/methodology/approach
This paper purposively sampled two social enterprises (SEs) and conducted in-depth case studies through interviews and secondary data review.

Findings
The SEs selected promoted digital, economic and social inclusion. Despite the diversity of the two organisations, they shared similar challenges in undertaking their practices mostly deriving from South Africa’s lack of legal recognition and policy framework for social purpose-driven businesses.

Originality/value
Applying Moulaert et al.’s (2007) SI classification criteria to the case studies in focus, this paper seeks to extend our understanding of the challenges that innovative SE organisations face in tackling exclusion and contributing to build inclusive economies in the South African context.
Using self-determination theory to assess the tourism service product at local level: the case of North Cyprus
Authors: Guden Nafiya , Safaeimanesh Farzad 
Published: May 2022

PurposeThis study draws on self-determination theory (SDT) and describes a study that elucidates how motivation can be fostered in the local management context. The study aims to provide state and local officials with a decision-making tool that allows evaluation of the quantity and quality of the public services by using SDT to interact with locals and students.Design/methodology/approachA qualitative approach and thematic analysis (TA) were used to find common themes and to develop an in-depth insight by gathering specific information from the point of view of local residents. In total, 19 interviews with locals were conducted using questions drawn from SDT.FindingsThe study found that the most significant obstacles were autonomy, competence and relatedness to intrinsic and extrinsic factors such as managing budgets, provision of basic services such as waste management, accessibility and support for local non-government organisations and local festivals and lack of knowledge about sustainable tourism product development among local residents.Originality/valueAlthough there is growing knowledge related to environmental and social concern, the municipality's engagement level in this area is low. Hence, the study provides state and local officials with a decision-making tool to evaluate public services' quantity and quality through the SDT on locals and students, and it is significant to explain the application of SDT to the tourism service at the local level and its potential to develop sustainable tourism.
Forecasting suppression of invasive sea lamprey in Lake Superior
Authors: Lewandoski Sean A. , Brenden Travis O. 
Published: May 2022

Abstract

Resource managers frequently are tasked with mitigating or reversing adverse effects of invasive species through management policies and actions. In Lake Superior, of the Laurentian Great Lakes, invasive sea lamprey populations are suppressed to protect valuable fish stocks. However, the relationship between choice of long‐term control strategy and the future chance of achieving the suppression target is unclear.

Using a 60+ year time series of suppression effort and monitoring data from 50 assessment sites located on Lake Superior tributaries, we developed a Bayesian state‐space model to forecast the probability of suppressing lamprey below the suppression target.

With annual application of lampricide (i.e. lamprey‐specific pesticide) at historical mean levels, we forecasted a 15% chance of achieving the Lake Superior sea lamprey suppression target in 2040.

Increasing lampricide effort and/or supplementing lampricide control with age‐1 recruitment reduction increased suppression chance. Annual application of the maximum historical lampricide effort resulted in a 50% predicted chance of achieving the target, annual application of the mean historic lampricide effort plus a 40% reduction in recruitment resulted in a 54% chance, and the maximum amount of effort considered (maximum historic lampricide and 60% reduction in recruitment) resulted in a 94% chance.

Policy implications. We developed a simulation model from a robust, long‐term monitoring dataset that improves understanding of why long‐term sea lamprey suppression objectives have been difficult to achieve in Lake Superior. Furthermore, the model provides a means to gauge efficacy of sea lamprey control policy and action scenarios based on forecasted chance of achieving the suppression target. Creating processes for iteratively refining our forecasting model with stakeholder and technical‐expert input and integration with a decision analysis framework could strengthen the link between ecological knowledge obtained from long‐term monitoring and invasive sea lamprey management.
Mercury bioremediation by engineered Pseudomonas putidaKT2440 with adaptationally optimized biosecurity circuit
Authors: Xue Yubin , Qiu Tianlei , Sun Zhi , Liu Feixia , Yu Bo 
Published: May 2022

SummaryHazardous materials, such as heavy metals, are the major sources of health risk. Using genetically modified organisms (GMOs) to dispose heavy metals has the advantages of strong environmental compatibility and high efficiency. However, the biosecurity of GMOs used in the environment is a major concern. In this study, a self‐controlled genetic circuit was designed and carefully fine‐tuned for programmable expression in Pseudomonas putida KT2440, which is a widely used strain for environmental bioremediation. The cell behaviours were controlled by automatically sensing the variation of Hg2+ concentration without any inducer requirement or manual interventions. More than 98% Hg2+ was adsorbed by the engineered strain with a high cell recovery rate of 96% from waterbody. The remaining cells were killed by the suicide module after the mission was accomplished. The escape frequency of the engineered P. putida strain was lower than 10−9, which meets the recommendation of US NIH guideline for GMOs release (<10−8). The same performance was achieved in a model experiment by using natural lake water with addition of Hg2+. The microbial diversity analysis further confirmed that the remediation process made little impact on the indigenous ecosystem. Thus, this study provides a practical method for environmental remediation by using GMOs.
Be wary about occult metastasis to cervical level I lymph node from a case of thyroglossal duct cyst carcinoma
Authors: Chow Tam Lin , Lee Clary K. L. 
Published: May 2022

AbstractBackgroundThyroid carcinoma arising from thyroglossal duct cyst is rare. Papillary thyroid carcinoma is the most frequent subtype but its biological behaviour, such as pattern of nodal spread, is largely elusive.MethodWe report one case of locally advanced papillary carcinoma arising from thyroglossal duct cyst with subclinical cervical level I lymph node metastasis which is an unexpected drainage area for its counterpart from the thyroid.ResultsSistrunk operation, total thyroidectomy and bilateral cervical level I lymph node dissection were performed. I131 ablation was administered postoperatively. Patient remained disease free after a follow‐up of 7 years.ConclusionThe reported case shed light on the nodal spread from thyroglossal duct cyst cancer and has bearing on the plan of surgical management.
Role of c‐Jun NH2‐terminal kinase‐mediated mitogen‐activated protein kinase pathway in response to pesticides in Apis cerana cerana
Authors: Niu Xiao‐Jing , Wang Li‐Jun , Meng Hui , Wang Hong‐Fang , Xu Bao‐Hua , Wang Chen 
Published: May 2022

AbstractThe mitogen‐activated protein kinase (MAPK) cascade pathway plays an important role in regulating stress responses. The function of the c‐Jun NH2‐terminal kinase (JNK), a component of the MAPK cascade pathway, in Apis cerana cerana (Acc) remains unclear. Here, JNK was isolated and identified from Acc. Bioinformatics analyses revealed there is a typical serine/threonine protein kinase catalytic domain in the AccJNK protein. An expression profile analysis showed that AccJNK was significantly induced by pesticide treatments. To further explore the functional mechanisms of AccJNK, a yeast 2‐hybrid screen was performed, activator protein‐1 (AP‐1) was screened as the interaction partner of AccJNK, and the interaction relationship was further verified by pull‐down assay. Quantitative real‐time polymerase chain reaction showed the expression pattern of AccAP‐1 was similar to that of AccJNK. After a knockdown of AccJNK or AccAP‐1 by RNA interference, the survival rate of Acc after pesticide treatments increased. Additionally, the expression levels of antioxidant‐related genes and the activities of antioxidant enzymes increased, suggesting that the knockdown of AccJNK or AccAP‐1 increased the antioxidant capacity of bees. Our study revealed that the JNK‐mediated MAPK pathway responds to pesticide stress by altering the antioxidant capacity of Acc.
Application of soluble gas stabilization technology on ready‐to‐eat pre‐rigor filleted Atlantic salmon (Salmo salar L.)
Authors: Jakobsen Anita Nordeng , Gabrielsen Lisa , Johnsen Elena Marie , Rotabakk Bjørn Tore , Lerfall Jørgen 
Published: May 2022

AbstractThe demand for high‐quality, convenient, and sustainable salmon products represents a potential for value‐added product development and novel packaging solutions. Soluble gas stabilization (SGS) technology, which applies dissolved CO2 in the product before packaging, represents a novel approach to retain product quality and prevent microbiological deterioration during cold storage of pre‐rigor filleted salmon loins.The present study aimed to examine the solubility of CO2 in salmon loins as affected by rigor status. In addition, the effect of predissolved CO2 on the overall quality of pre‐rigor vacuum‐packed Atlantic salmon (Salmo salar L.) was investigated during storage at 4°C. The CO2 pretreatment was conducted, exposing loins to 100% CO2 for 18 h at 4°C (the control group was kept in air at 4°C) before repackaging and storage for 15 days.Dissolved CO2 in the muscle (equilibrium achieved four days post packaging) was slightly higher in pre‐rigor than post‐rigor salmon loins (pequilibrium = 0.006). Moreover, the overall spoilage (Hvalue) and microbiological stability of salmon fillets stored in SGS‐vacuum were significantly improved compared to vacuum‐packed loins (p < 0.05).The results demonstrate that SGS technology can maintain the overall quality of pre‐rigor vacuum‐packed salmon loins without introducing the high gas‐to‐product volume ratio recognized by modified atmosphere packaging. Thus, the application of SGS technology on pre‐rigor loins can lead to higher economic gain and environmental benefits due to the reduced amount of required packaging material and reduced food waste.Practical ApplicationCO2 can be dissolved in pre‐rigor salmon loins before vacuum packaging to increase product shelf life during cold storage.
Integrative analysis of clinical and epigenetic biomarkers of mortality
Authors: Huan Tianxiao , Nguyen Steve , Colicino Elena , Ochoa‐Rosales Carolina , Hill W. David , Brody Jennifer A. , Soerensen Mette , Zhang Yan , Baldassari Antoine , Elhadad Mohamed Ahmed , Toshiko Tanaka , Zheng Yinan , Domingo‐Relloso Arce , Lee Dong Heon , Ma Jiantao , Yao Chen , Liu Chunyu , Hwang Shih‐Jen , Joehanes Roby , Fornage Myriam , Bressler Jan , van Meurs Joyce B.J. , Debrabant Birgit , Mengel‐From Jonas , Hjelmborg Jacob , Christensen Kaare , Vokonas Pantel , Schwartz Joel , Gahrib Sina A. , Sotoodehnia Nona , Sitlani Colleen M. , Kunze Sonja , Gieger Christian , Peters Annette , Waldenberger Melanie , Deary Ian J. , Ferrucci Luigi , Qu Yishu , Greenland Philip , Lloyd‐Jones Donald M. , Hou Lifang , Bandinelli Stefania , Voortman Trudy , Hermann Brenner , Baccarelli Andrea , Whitsel Eric , Pankow James S. , Levy Daniel 
Published: May 2022

AbstractDNA methylation (DNAm) has been reported to be associated with many diseases and with mortality. We hypothesized that the integration of DNAm with clinical risk factors would improve mortality prediction. We performed an epigenome‐wide association study of whole blood DNAm in relation to mortality in 15 cohorts (n = 15,013). During a mean follow‐up of 10 years, there were 4314 deaths from all causes including 1235 cardiovascular disease (CVD) deaths and 868 cancer deaths. Ancestry‐stratified meta‐analysis of all‐cause mortality identified 163 CpGs in European ancestry (EA) and 17 in African ancestry (AA) participants at p < 1 × 10−7, of which 41 (EA) and 16 (AA) were also associated with CVD death, and 15 (EA) and 9 (AA) with cancer death. We built DNAm‐based prediction models for all‐cause mortality that predicted mortality risk after adjusting for clinical risk factors. The mortality prediction model trained by integrating DNAm with clinical risk factors showed an improvement in prediction of cancer death with 5% increase in the C‐index in a replication cohort, compared with the model including clinical risk factors alone. Mendelian randomization identified 15 putatively causal CpGs in relation to longevity, CVD, or cancer risk. For example, cg06885782 (in KCNQ4) was positively associated with risk for prostate cancer (Beta = 1.2, PMR = 4.1 × 10−4) and negatively associated with longevity (Beta = −1.9, PMR = 0.02). Pathway analysis revealed that genes associated with mortality‐related CpGs are enriched for immune‐ and cancer‐related pathways. We identified replicable DNAm signatures of mortality and demonstrated the potential utility of CpGs as informative biomarkers for prediction of mortality risk.
Effects of e‐cigarette use on mental health among youths: quasi‐experimental evidence from Canada
Authors: Nguyen Hai V. , Mital Shweta 
Published: May 2022

AbstractBackground and AimsExisting research on mental health comorbidities of youth e‐cigarette use is subject to confounding bias and reverse causality. This study aimed to measure the effects of e‐cigarette use on youth mental health, using e‐cigarette minimum legal age (MLA) law in Canada as a natural experiment.DesignWe used difference‐in‐differences (DD), difference‐in‐differences‐in‐differences (DDD) and two‐sample instrumental variables (TSIV) methods.SettingData were from nationally representative Canadian Community Health Surveys 2008–2019 and Canadian Student Tobacco Alcohol and Drugs Surveys 2008–2019.ParticipantsThe study sample comprised of respondents aged 15 to 18 (in DD analysis; n = 33 858) and aged 15 to 24 (in DDD analysis; n = 78 689).MeasurementsPrimary outcomes were self‐reported mood disorders and anxiety disorders. Secondary outcomes were cannabis use, illicit drug use, cigarette use and strength of peer relationships at schools.FindingsAfter the e‐cigarette MLA laws, risks of mood disorders declined by 1.9 percentage points (95% CI, 0.0–3.8; P = 0.05) in the DD analysis and by 2.6 percentage points (95% CI, 0.2–5.0; P = 0.03) in the DDD analysis. For anxiety disorders, while the DD estimate was negative but imprecisely estimated, the MLA law reduced risks of anxiety disorder by 3.6 percentage points (95% CI, 0.9–6.2; P = 0.01) in the DDD analysis. Youths in provinces with MLA laws were also less likely to report cannabis use and illicit drug use and more likely to feel being part of schools. TSIV analysis indicates that youth e‐cigarette use increased the likelihood of mood and anxiety disorders by 44% and 37%, respectively.Conclusion and RelevanceIn Canada, the e‐cigarette minimum legal age law appears to have reduced risks of mood and anxiety disorders, lowered substance use and improved peer relationships at schools. Combined with previous evidence of lower e‐cigarette use following the minimum legal age law, our findings indicate that youth e‐cigarette use increases risks of mood and anxiety disorders.
Robotic pelvic side‐wall dissection and en‐bloc excision for locally advanced and recurrent rectal cancer: outcomes on feasibility and safety
Authors: Lokuhetty Naradha , Larach José Tomás , Rajkomar Amrish K. S. , Mohan Helen , Waters Peadar S. , Heriot Alexander G. , Warrier Satish K. 
Published: May 2022

AbstractBackgroundGlobal differences exist in managing lateral pelvic nodes in rectal cancer. Recent studies demonstrate improved local recurrence rates in patients undergoing lateral pelvic lymph node dissections (LPND) in addition to total mesorectal excision (TME) for advanced lower rectal cancer. This study aims to report on the safety and feasibility of the robotic approach in patients undergoing pelvic sidewall lymph node dissection or en‐bloc sidewall resection for advanced lower rectal cancer.MethodsPatients who underwent an elective robotic pelvic sidewall lymph node dissection or en‐bloc sidewall resection for locally advanced rectal cancer with suspicious lateral lymph nodes or pelvic side wall involvement between January 2018 and March 2021 were included. Demographic, clinical, perioperative and histopathological variables were recorded and analysed.ResultsEight patients (3 males) with a mean age of 55 (33–73) years and mean body mass index of 26.3 (20.7–30.0) kg/m2 were included. The median operative time and blood loss were 458.75 (360–540) min and 143.75 (100–300) mL, respectively. There were no conversions or intra‐operative complications. There were three post‐operative complications recorded (two ileus and one anastomotic leak which required an endoscopic washout in theatre and intravenous antibiotics thereafter). Median length of stay was 12.75 (7–23) days. All patients had an R0 resection, and the median lateral pelvic lymph node yield was 9.1 (6–14).ConclusionThis series demonstrates the practicality and the safety of the robotic approach in the introduction of this technique for en‐bloc resection or LPND in patients with locally advanced rectal cancer.
The role of elbow positioning on arthroscopic assessment of the long head of biceps tendon in the beach chair position
Authors: Ek Eugene T. , Flynn Jennifer N. , Boyce Glenn N. , Padmasekara Gayan 
Published: May 2022

AbstractBackgroundTendinopathy of the long head of biceps (LHB) tendon is a common cause of anterior shoulder pain and dysfunction. The extra‐articular portion within the bicipital groove undergoes frequent load and friction during shoulder movements and pathology within this area is frequently missed during arthroscopic assessment.MethodsWe quantified the arthroscopically assessable length of tendon within the shoulder in 14 consecutive patients undergoing subpectoral biceps tenodesis. After biceps tenotomy at the superior labrum, the tagged tendon was maximally tensioned and marked at the biceps outlet with the elbow in extension and flexion. The distance in distance between the two were measured.ResultsMean distance from the superior labral insertion of the biceps to the outlet was 16.4 ± 4.1 mm (range, 11–25). With tension on the biceps with elbow extension, the mean measurable distance was 31.3 ± 6.7 mm (range, 19–45). With elbow flexion, this increased to 39.5 ± 5.9 mm (range, 25–52). Mean increase in visible tendon length was 8.2 ± 4.3 mm (range, 5–21) (p = 0.002).ConclusionElbow flexion results in an average increase of 26.2% more extra‐articular tendon visualized at arthroscopy. Therefore, we believe that elbow flexion is a useful adjunct, especially when performed in conjunction with techniques that pull the tendon into the joint, thus allowing for more complete arthroscopic assessment of the LHB, increasing detection of symptomatic biceps tendonitis.Level of evidence: Level IV.