bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unknown system dynamics estimator based coordinated control of the ultra supercritical boiler‐turbine unit with coal pulverizing delay for large load accommodation
Authors: Li Yunpeng , Yang Qinmin , Meng Wenchao 
Published: November 2022

AbstractThe ultra‐supercritical boiler‐turbine unit is required to accommodate large‐range load following to maintain the stability of grid frequency. However, the input delay in the coal pulverizing process poses a challenge to the coordinated control of the boiler‐turbine unit, which is always neglected in existing works but dramatically affects the stability of steam pressure and temperature. In this paper, to handle the delay caused by coal pulverizing, a predictor‐based delay compensation structure is developed for producing a delay‐free control framework for the throttle steam pressure. Moreover, to overcome intrinsic nonlinearities in the dynamics of the boiler‐turbine unit, the unknown system dynamics estimator is employed in the controllers' design for the steam enthalpy in the separator and active power of the turbine. Thus, precise and fast regulation for the active power output can be achieved under wide load following task. The salient merit of the proposed control is that the overshot of the throttle steam pressure and the specific enthalpy in the separator can be significantly alleviated, which is necessary for turbine blade. A Lyapunov‐Krasovskii functional is introduced to deal with the time delay in the stability proof. Finally, the proposed coordinated control is validated in three typical working scenarios.
The importance of low IQ to early diagnosis of autism
Authors: Denisova Kristina , Lin Zhichun 
Published: November 2022

AbstractSome individuals can flexibly adapt to life's changing demands while others, in particular those with Autism Spectrum Disorder (ASD), find it challenging. The origin of early individual differences in cognitive abilities, the putative tools with which to navigate novel information in life, including in infants later diagnosed with ASD remains unexplored. Moreover, the role of intelligence quotient (IQ) vis‐à‐vis core features of autism remains debated. We systematically investigate the contribution of early IQ in future autism outcomes in an extremely large, population‐based study of 8000 newborns, infants, and toddlers from the US between 2 and 68 months with over 15,000 cross‐sectional and longitudinal assessments, and for whom autism outcomes are ascertained or ruled out by about 2–4 years. This population is representative of subjects involved in the National Institutes of Health (NIH)‐funded research, mainly on atypical development, in the US. Analyses using predetermined age bins showed that IQ scores are consistently lower in ASD relative to typically developing (TD) children at all ages (p < 0.001), and IQ significantly correlates with social, non‐social, and total Calibrated Severity Scores (CSS) on the Autism Diagnostic Observation Schedule (ADOS) (p<0.01). Lower IQ is associated with greater autistic impairments. Note, verbal IQ (VIQ) is no better than the full‐scale IQ to predict ASD cases. These findings raise new, compelling questions about potential atypical brain circuitry affecting performance in both verbal and nonverbal abilities and preceding an ASD diagnosis. This study is the first to establish prospectively that low early IQ is a major feature of ASD in early childhood.Lay SummaryThe role of IQ scores in autism remains debated. We systematically investigate the contribution of early IQ in an extremely large study of 8,000 children between 2 and 68 months with autism outcomes by about 2–4 years. We show that IQ scores are consistently lower in ASD relative to TD children. This study is the first to establish prospectively that low early IQ is a predictor for ASD diagnosis in early childhood.
Acid digestion and symbiont: Proton sharing at the origin of mitochondriogenesis?
Authors: Mencía Mario 
Published: November 2022

AbstractThe initial relationships between organisms leading to endosymbiosis and the first eukaryote are currently a topic of hot debate. Here, I present a theory that offers a gradual scenario in which the origins of phagocytosis and mitochondria are intertwined in such a way that the evolution of one would not be possible without the other. In this scenario, the premitochondrial bacterial symbiont became initially associated with a protophagocytic host on the basis of cooperation to kill prey with symbiont‐produced toxins and reactive oxygen species (ROS). Subsequently, the cooperation was focused on the digestion stage, through the acidification of the protophagocytic cavities via exportation of protons produced by the aerobic respiration of the symbiont. The host gained an improved phagocytic capacity and the symbiont received organic compounds from prey. As the host gradually lost its membrane energetics to develop lysosomal digestion, respiration was centralized in the premitochondrial symbiont for energy production for the consortium.
Gamma oscillations and application of 40‐Hz audiovisual stimulation to improve brain function
Authors: Chen Xixi , Shi Xiaolong , Wu Yuwei , Zhou Zhiqing , Chen Songmei , Han Yan , Shan Chunlei 
Published: November 2022

AbstractBackgroundAudiovisual stimulation, such as auditory stimulation, light stimulation, and audiovisual combined stimulation, as a non‐invasive stimulation, which can induce gamma oscillation, has received increased attention in recent years, and it has been preliminarily applied in the clinical rehabilitation of brain dysfunctions, such as cognitive, language, motor, mood, and sleep dysfunctions. However, the exact mechanism underlying the therapeutic effect of 40‐Hz audiovisual stimulation remains unclear; the clinical applications of 40‐Hz audiovisual stimulation in brain dysfunctions rehabilitation still need further research.ObjectiveIn order to provide new insights into brain dysfunction rehabilitation, this review begins with a discussion of the mechanism underlying 40‐Hz audiovisual stimulation, followed by a brief evaluation of its clinical application in the rehabilitation of brain dysfunctions.ResultsCurrently, 40‐Hz audiovisual stimulation was demonstrated to affect synaptic plasticity and modify the connection status of related brain networks in animal experiments and clinical trials. Although its promising efficacy has been shown in the treatment of cognitive, mood, and sleep impairment, research studies into its application in language and motor dysfunctions are still ongoing.ConclusionsAlthough 40‐Hz audiovisual stimulation seems to be effective in treating cognitive, mood, and sleep disorders, its role in language and motor dysfunctions has yet to be determined.
Towards sustainable development in the hospitality sector: Does green human resource management stimulate green creativity? A moderated mediation model
Authors: Abualigah Ahmad , Koburtay Tamer , Bourini Islam , Badar Kamal , Gerged Ali Meftah 
Published: November 2022

AbstractGreen human resource management (GHRM) is an important organisational approach to promote the sustainable development of organisations. Although the literature regarding the effect of GHRM is growing, little is known about the mechanisms and boundary conditions that may facilitate the link between GHRM and green outcomes. Through a combined underpinning of ability–motivation–opportunity, job demands–resources and social exchange theories, this study examines the relationship between GHRM and green creativity through green work engagement, with spiritual leadership moderating the GHRM–green work engagement relationship. Also, we explore the links between GHRM, spiritual leadership, green work engagement and green creativity using a moderated mediation model. Using survey data of 271 front‐line hotel employees in UAE, we use a partial least squares structural equation modelling to conduct our statistical analysis. The results show that GHRM positively influences green work engagement and green creativity, while green work engagement positively influences green creativity and mediates the GHRM–green creativity nexus. In addition, spiritual leadership amplifies the nexus between GHRM and green work engagement and the mediating effect of green work engagement in the nexus between GHRM and green creativity in the context of the hospitality sector in the UAE. Our study offers industry‐specific practical implications and suggests agendas for further research.
Impact of high neutrophil‐to‐lymphocyte ratio on survival in hospitalized cancer patients with COVID‐19
Authors: Díaz‐Couselo Fernando A. , Flagel Santiago , Nicolini Carla , Halac Sebastián , Manzano Natalia , Aguirre Marina , Rébora Juan , Valle Sandra , Noro Laura , Mohindroo Chirayu , McAllister Florencia , Zylberman Marcelo 
Published: November 2022

AbstractNeutrophil‐to‐lymphocyte ratio (NLR) has been studied as a prognostic factor for mortality in COVID‐19 patients. Our study aimed to evaluate the association between NLR at COVID‐19 diagnosis and survival during the following 90 days in hospitalized patients with solid cancer. Between May 2020 and June 2021, 120 patients were included in a retrospective cohort study. Univariable analysis showed patients with an NLR > 8.3 were associated with an increased risk of death (HR: 4.34; 95% CI: 1.74–10.84) compared to patients with NLR < 3.82 and with NLR ≥3.82 and ≤8.30 (HR: 2.89; 95% CI: 1.32–6.36). Furthermore, on multivariable analysis, NLR > 8.30 independently correlated with increased mortality. In patients with solid malignancies with COVID‐19, an NLR > 8.3 is associated with an increased risk of death.
Post‐kidney transplant cancers: Racial and ethnic differences in sun‐exposed skin versus non‐sun‐exposed anogenital skin
Authors: Takeda Kotaro , Risley Carolann , Kousar Aisha , Briley Kimberly P. , Prenshaw Karyn , Talluri Rajesh , Geisinger Kim R. , Rebellato Lorita M. 
Published: November 2022

AbstractBackgroundTransplant recipients have a 2‐ to 4‐fold increased risk of developing malignancies over the general population. Cancer is the second most common cause of death for recipients. The magnitude of the risk depends on the cancer type and increases in viral‐related malignancies. Skin cancer is the most common. However, data in most cancer registries is limited to cutaneous melanomas, thereby limiting the epidemiologic examination of cancer risk in non‐melanoma skin cancer. Our goal was to evaluate post‐kidney transplant cancer cases and sites in our population to guide screening recommendations.MethodsBetween 2009 and 2015, a retrospective study of adult kidney recipients transplanted at East Carolina University was conducted. The first cancer diagnosis after transplant through February 18, 2020, was captured and analyzed. Patient demographics, cancer sites, and histological diagnoses were analyzed and compared. p16 immunohistochemistry was used as a surrogate marker for high‐risk human papillomavirus (HPV) infection.ResultsRetrospectively, kidney transplant recipients were analyzed (N = 439), the majority were non‐Hispanic Black (NHB) individuals, 312 (71.1%), and 127 (28.9%) were non‐Hispanic White (NHW) individuals. Of these, 59 (13.4%) developed a posttransplant malignancy, with the majority on sun‐exposed skin found in NHW. NHB had all anogenital/mucosa skin cancers on non‐sun‐exposed skin. Of these detected in NHB, all were squamous cell carcinomas, with five out of six (83.3%) being positive for p16.ConclusionsPosttransplant malignancy differed significantly by race, site, and potential source of etiology. The majority of malignancies are likely explained by acceleration of precursor lesions from prior exposure to ultraviolet rays or HPV.
Cost‐effectiveness of first‐line versus second‐line use of domestic anti‐PD‐1 antibody sintilimab in Chinese patients with advanced or metastatic squamous non‐small cell lung cancer
Authors: Cheng Rihua , Zhou Zhen , Liu Qiao 
Published: November 2022

AbstractBackgroundProgrammed cell death protein‐1/programmed cell death ligand‐1 (PD‐1/L1) inhibitor is a promising therapeutic option that can be used as either a first‐line or second‐line treatment for driver‐negative advanced or metastatic squamous non‐small cell lung cancers (sqNSCLC). However, reuse of PD‐1/L1 inhibitor in second‐line beyond progression after the first‐line is generally not recommended. Therefore, oncologists face challenges in making a proper decision of using PD‐1/L1 inhibitor. This analysis aimed to determine whether it is more cost‐effective to use sintilimab, a domestic anti‐PD‐1 drug in China, as a first‐line treatment than reserving it until second‐line.MethodsWe conducted a cost‐effectiveness analysis to compare the use of sintilimab in the first‐line setting with reserving its use until the second‐line for driver‐negative advanced or metastatic sqNSCLC from the perspective of the Chinese healthcare system. A Markov model composed of five main mutually independent health states and three temporary health states was established to simulate patients' clinical trajectory. Transition probabilities, including disease progression, survival, and adverse events‐related treatment discontinuation, were estimated using data from the ORIENT‐12, ORIENT‐3, and ALTER0303 clinical trials. The robustness of the model was assessed using deterministic sensitivity analysis (DSA) and probabilistic sensitivity analyses.ResultsReserving the use of sintilimab until the second‐line was associated with a greater effectiveness (1.52 vs. 1.37 quality‐adjusted life‐years [QALYs]) and a higher healthcare cost ($12,203 vs. $14,045) compared with the first‐line sintilimab, resulting in an incremental cost‐effectiveness ratio (ICER) of $12,693 per QALY. The results of DSA suggested that variations in all parameters did not result in the ICERs surpassing the willingness‐to‐pay threshold of $35,663/QALY.ConclusionsFor Chinese patients with driver‐negative advanced or metastatic sqNSCLC, reserving the use of sintilimab until the second‐line represents a cost‐effective treatment strategy compared with the first‐line treatment. This finding is useful to inform Chinese healthcare policymakers regarding the optimized treatment strategies of use of domestic PD‐1/L1 inhibitors sintilimab.
Differential privacy protection method for trip‐oriented shared data
Authors: Du Danlei , Luo Entao , Yi Yang , Peng Tao , Li Xubin , Zhang Shaobo , Jiang Xu , Wang Tian 
Published: November 2022

SummaryWhile location information sharing technology provides convenience for unmanned driving and journey navigation, user journey information sharing has also become a disaster for privacy information leakage. The traditional differential privacy method can only perturb the data entirely and cannot consider the design of data availability. In this paper, the difference privacy algorithm is improved by combining it with the Apriori algorithm, and the relevant perturbation is carried out after mining the associated data of the user's trip. In the face of possible data attacks, the privacy protection of the sensitive information of the user's actual data is ensured while the availability of the data is ensured. By testing 3000 trip data generated by experimental simulation, the results show that the correlation information between the original datasets is destroyed. However good availability is maintained after the Laplace data perturbation of the proposed algorithm for both simultaneous and multi‐person trips.
Recognizing the Indian Cautionary Traffic Signs usingGAN, Improved MaskR‐CNN, and Grab Cut
Authors: Satti Satish Kumar , K Suganya Devi , P Srinivasan 
Published: November 2022

SummaryThe detection and classification of traffic signs is a major challenge for self‐driving vehicles. The task can be narrowed down to detecting and classifying Indian Cautionary Traffic Signs (ICTS). In this proposed work, the difficulty of detecting and identifying Indian Cautionary Traffic Signs is addressed, and sincere attempts have been made to attain a possible solution using a Generative Adversarial Network (GAN), Improved Mask R‐CNN, and GrabCut algorithms. Data augmentation is done using Cascade Pyramid Generative Adversarial Network (CP‐GAN) to upsize the data set. The Mask R‐CNN with certain adoptions termed Improved mask RCNN is used in conjunction with the Grab‐Cut method to handle ICTS detection and identification through automatic end‐to‐end learning. Initially, Improved Mask R‐CNN generates a pixel‐by‐pixel segmentation mask for each item in the input sample. Masks developed using Improved Mask R‐CNN are not always clean, that is, some background pixels are often seen in the foreground segmentation. Hence, the generated masks are refined using the Grab Cut algorithm to enhance image segmentation. This combined approach works well in isolating the traffic signs from the ground truth images. Improved Mask R‐CNN attained better performance in the overall performance of traffic sign detection in the Indian data‐set. This method recognizes 40 different types of cautionary traffic signs from the unique Indian data set. The results are provided for complicated traffic sign categories that have not been addressed before. The proposed technique is trained and evaluated on ICTS, GTSDB, STSD, LISA, and DITS data sets, and it is also compared against cutting‐edge object recognition methods like Mask RCNN, Faster RCNN, SSD, and YOLOv3.
The firm under the spotlight: How stakeholder scrutiny shapes corporate social responsibility and its influence on performance
Authors: Forcadell Francisco Javier , Lorena Antonio , Aracil Elisa 
Published: November 2022

AbstractSince stakeholders cannot directly observe corporate social responsibility (CSR) efforts, companies attempt to back up their increasing sustainability claims by sending CSR signals. The environment in which signaling takes place influences the credibility of the signals. Among the factors that make up the signaling environment, the overall exposure of the company to different stakeholders (i.e., stakeholder scrutiny) has been neglected by the literature. Using signaling and stakeholder theories, we argue how stakeholder scrutiny shapes CSR signals' credibility. We empirically analyze a sample of 5762 firms across several sectors from 23 developed countries from 2013 to 2017. Stakeholder scrutiny exercises a positive effect on the credibility of CSR signals through a mediated‐moderated impact of CSR (across environmental, social, and governance dimensions) on firm performance.
Immobilization of Lipoxygenase, Catalase, and Lipase for a Reactor Design Targeting Linoleic Acid Hydroperoxidation
Authors: Gala Marti Valentin , Müller Christoph , Spektor Vitaliy , Schörken Ulrich 
Published: November 2022

AbstractHydroperoxy‐9Z,11E‐octadecadienoic acid (13‐HPODE) can be obtained from safflower oil in an enzyme cascade utilizing lipase, lipoxygenase (LOX), and catalase for in situ oxygen generation. The application of immobilized enzymes may open a new path to a cost‐efficient production of 13‐HPODE, which is used for the synthesis of green note aroma hexanal. Ten immobilization supports are compared for immobilization of lipoxygenase‐1 from Glycine max (LOX‐1) and oxirane‐based Immobead 150 P proves to be best with a maximum LOX‐1 activity of 22 470 U g−1. The immobilizate is successfully recycled in eight consecutive batches and maintains full activity over a period of 16 h using a 3D‐printed column reactor. Catalase from Micrococcus lysodeikticus and LOX‐1 are co‐immobilized on Immobead 150 P allowing a constant production of 13‐HPODE for up to six cycles with a maximum product conversion of 45% and a 13‐regioselectivity of 83%
. In this two‐enzyme system with H2O2‐dosage, foam generation is significantly reduced. Co‐immobilization of LOX‐1 and lipaseis possible; however, rapid lipase deactivation occurs. Therefore, a two‐reactor approach with oil hydrolysis in the first reactor is proposed. Immobilized lipases from C. rugosa are suitable for safflower oil hydrolysis and maintain full activity over ten hydrolysis cycles.Practical applications: Linoleic acid hydroperoxide (13‐HPODE) is the starting material for the synthesis of the green note aroma compound hexanal. The byproduct of the hydroperoxide splitting is ω‐oxododecenoic acid, which is currently not employed industrially. The bifunctional oxodocecenoic acid is interesting as precursor for the synthesis of polymer building blocks. Simple one‐step derivatization of the oxo‐group can yield suitable C12 monomers such as dicarboxylic acids, ω‐amino acids, or ω‐hydroxy acids. Cost‐efficiency is a key parameter to incorporate these new biobased building blocks for polymer applications. In this approach, immobilized enzymes are used for the synthesis of 13‐HPODE starting from safflower oil with in situ oxygen generation to prevent excessive foam formation. A two‐reactor concept is designed to circumvent hydroperoxide‐induced lipase deactivation. Direct comparison of both batch and continuous process is performed and provides information for the implementation of the enzyme cascade and the design of an optimized reactor system.
RETRACTED: Internet of Things security framework based on near field communication with Otway Rees protocol
Authors: Musa Jaber Mustafa , Yussof Salman , Ali Mohammed Hassan , Khalil Abd Sura , Jassim Mustafa Mohammed , Alkhayyat Ahmed 
Published: November 2022

AbstractInternet of Things (IoT) devices are crucial in different industries because they provide high‐functioning services to the IoT network connectivity. The IoT devices collect sensitive data, which comes under potential risk while transmitting data from one location to another. The data transmission is performed using various communication protocols that give security to the data. The intermediate attacks such as jamming, collision, flooding, worm‐hole, black‐hole and so forth create several security‐related issues. These intermediate attacks affect data privacy, trust, user identity, which completely affects the IoT device performance. So, this article introduces the near field communication (NFC) protocol with the Otway Rees protocol for making the secure communication process. In IoT applications based on short‐range communication, intermediate attacker issues have been reduced by combining NFC protocol features with Otway Rees protocol features. The NFC protocol provides baseline security trustworthiness while making the communication in the IoT environment cost‐effective. IoT communication is protected while cost‐effective using the security model, ensuring data integrity and confidentiality. In addition to this, the user and servers are authenticated for every session, which provides data security. Moreover, the discussed system is implemented using the NS2 simulation tool, ensuring security and trust with minimum complexity. Even in abnormal traffic conditions, our proposed method resulted in data transmission speeds (up to 289 Kb/s), and this feature can improve processing times.