bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased expression of leucine-rich α-2 glycoprotein 1 as a predictive biomarker of favorable progression-free survival in meningioma
Authors: Furuta Takuya , Moritsubo Mayuko , Miyoshi Junko , Komaki Satoru , Sakata Kiyohiko , Miyoshi Hiroaki , Morioka Motohiro , Ohshima Koichi , Sugita Yasuo 
Published: April 2022

Abstract
Purpose Most meningiomas, which are frequent central nervous system tumors, are classified as WHO grade 1 because of their slow growing nature. However, the recurrence rate varies and is difficult to predict using conventional histopathological diagnoses. Leucine-rich α-2 glycoprotein 1 (LRG1) is involved in cell signal transduction, cell adhesion, and DNA repair and is a predictive biomarker in different malignant tumors; however, such a relationship has not been reported in meningiomas. Methods/patients We examined tissue microarrays of histological samples from 121 patients with grade I and grade II meningiomas and assessed their clinical and pathological features, including expression of LRG1 protein. Results LRG1-high meningiomas showed increased number of vessels with CD3 positive cell infiltration (p=0.0453) as well as higher CD105 positive vessels (p=0.0041), as compared to LRG1-low cases. They also demonstrated better progression-free survival [hazard ratio (HR) 0.24, 95 % confidence interval (CI) 0.056-0.99] compared to LRG1-low patients (p=0.0317). Moreover, multivariate analysis indicated that high LRG1 expression was an independent prognostic factor (HR, 0.22; CI, 0.05-0.95; p=0.0426). Conclusions LRG1 immunohistochemistry may be a convenient tool for estimating the prognosis of meningiomas in routine practice. Further studies are required to elucidate the key role of LRG1 in meningioma progression.
MIKS - ein inklusives Professionalisierungs- und Schulentwicklungskonzept im Handlungsfeld Mehrsprachigkeit
Authors: Lange Imke 
Published: April 2022

Das MIKS-Konzept ist ein Konzept für die Schulentwicklungsarbeit mit Grundschulkollegien, die alle Sprachen ihrer Schüler*innen wertschätzen und für das Lernen nutzen wollen. Ziel ist die Professionalisierung und Qualifizierung des Personals und die Unterstützung von Schulentwicklungsprozessen. Die Grundschulkollegien entwickeln und erproben eigene Praxisvorhaben zum Einbezug von Mehrsprachigkeit, implementieren sie in die regulären Schul- und Unterrichtsabläufe und gestalten so die Schulentwicklung im Handlungsfeld Mehrsprachigkeit selbst.
Das MIKS-Konzept enthält Vorgaben über den Ablauf und die Methoden der Qualifizierung und Schulbegleitung sowie über die Inhalte, die während der Qualifizierung vermittelt und bearbeitet werden. Das MIKS-Konzept wurde 2013-2016 entwickelt und in drei Grundschulen erprobt. Im Rahmen einer Dissemination wurde das Konzept 2016-2019 durch Multiplikator*innen in die Breite getragen und an weiteren 17 Grundschulen durchgeführt. Der Artikel fokussiert zunächst die theoretische Fundierung und Konzeptionalisierung von MIKS. Im zweiten Teil werden die Inhalte, die Anlage und der Ablauf der Qualifizierung erstmals ausführlich vorgestellt und durch Einblicke in bisherige Erfahrungen illustriert.Abstract
The MIKS concept aims at school development and is carried out in elementary schools, which want to value all their students' languages and use them for learning. The aim is the professionalisation and qualification of the staff and the support of school development processes. The primary school colleges develop and test their own multilinguals teaching approaches and implement them in the everyday school routines. The concept includes the transfer of knowledge (psycholinguistic and sociolinguistic foundations), trial phases in lessons (via the implementation of multilingual teaching approaches), and guided reflection exercises concerning the experiences and beliefs among the participating staff.
The MIKS concept was developed in 2013-2016 and was carried out in three elementary schools. As part of a dissemination, the concept 2016-2019 was broadened by multipliers and carried out at further 17 elementary schools. The article focuses on the theoretical foundation and conceptualisation of MIKS. In the second part the contents and the course of the MIKS concept are presented in detail for the first time.
„Was könnte denn das Kind haben?“ Dynamiken der Kooperation von Kindertagesbetreuung und Frühförderung im Kontext inklusionsbezogener Professionalisierung
Authors: Hamacher Catalina , Seitz Simone 
Published: April 2022

Auf der Basis einer einführenden Darlegung des Diskurses zur Qualifizierung für inklusive Bildung fokussiert der Beitrag das professionalisierungsbezogene Anliegen der Kooperation von Kindertagesbetreuung und Frühförderung. Es werden ausgewählte Befunde aus dem qualitativen Teil einer abgeschlossenen Untersuchung (mixed methods) zur inklusionsförderlichen Kooperation von Kindertageseinrichtungen und Frühförderstellen herangezogen. Dabei kommt Fallkonstitutionen eine spezifische Bedeutsamkeit zu. Die Befunde werden vor dem Hintergrund von divergenten Orientierungsrahmen und Beauftragungen vertiefend diskutiert, worüber sich ein neuer Blick auf die ungleichheitsbezogene Bedeutsamkeit der Kooperationsprozesse eröffnet. Die Überlegungen werden abschließend zu professionalisierungs- und forschungsbezogenen Implikationen geführt.Abstract
On the basis of an introductory presentation of the discourse on qualification for inclusive education, the article focuses on the professionalisation-related concern of collaboration between day care and early intervention. Reference is made to selected findings from the qualitative part of a completed study (mixed methods) on the inclusion-related collaboration of professionals in Early Education and Early Intervention whereby case constellations have a specific significance. The findings are discussed in terms of divergent orientation frameworks and mandates, which opens up a new perspective on the inequality related significance of collaboration. Finally, the reflections will lead to professionalisation- and research-related implications.
Evaluation of biomarkers in the studies of keloid tissue after laser therapy
Authors: Tikhomirov A. L. , Kazenashev V. V. 
Published: April 2022

The main metabolite of lactobacilli, regulating their anti-inflammatory functions, is lactic acid (LA), which maintains the physiological state of the microbiocenosis of the vagina of women of reproductive age. Normocenosis of the vagina is based on a combination of acidic environment and colonization resistance. Pathogenic and conditionally pathogenic pathogens are colonized mainly in an alkaline environment. LA is an important biological substrate that supports the vaginal microbiota. Normally, the reaction of the vaginal contents is a pH of 3.8 to 4.5, and only in this case lactobacilli predominate in the biotope, which are able to unite into special communities – biofilms, forming the most powerful factor in protecting the vagina from adhesion and invasion of pathogens: a full-fledged lactobacillary biofilm is often able to prevent adhesion of even STI pathogens. Disruption of the functioning of each of the links of protection of the vaginal microbiome leads to a change in the pH of the habitat and excessive reproduction of conditionally pathogenic microorganisms. A frequent infectious syndrome, accompanied by an imbalance of the vaginal microbiota and the replacement of lactoflora with various types of anaerobic microorganisms (Gardnerella vaginalis, Ureaplasma urealyticum, Mycoplasma hominis, Mobiluncus, Prevotella), is bacterial vaginosis. When prescribing antibacterial treatment, side effects are possible: allergic reactions, hepatotoxic, nephrotoxic, candidiasis. The review presents the possibility of using LA, which is a basis in the composition of the drug Lactodepantol (Femilex®) – vaginal suppositories containing 100 mg of LA, as the main factor regulating the natural composition of the vaginal microbiota and the possibility of using vaginal suppositories based on LA (lactodepantol) for the prevention and treatment of bacterial vaginosis in the form of monotherapy and in combination with antimicrobials.
Awareness of young women about emergency contraception in the temporal aspect
Authors: Sviridova N. I. , Tkachenko L. V. , Gritsenko I. A. 
Published: April 2022

Introduction. Bearing in mind functional features of the reproductive system at every stage of a woman’s life, as it grows and develops, accomplishes its purpose and early fades away, its high vulnerability becomes obvious. Therefore, what emerges is the need for a broader analysis of the causes of reproductive dysfunction, among which termination of unwanted pregnancies plays one of the leading roles.Aim. To assess the level of awareness of emergency contraception among young women.Materials and methods. We conducted an anonymous voluntary survey on the awareness of the emergency contraception methods among different age groups of young people in 2014 and 2021. In 2014, 577 respondents participated in the survey, which were divided into two groups. Group 1 included 265 adolescent girls aged 15 to 17 years, group 2 included young women aged 18 to 25 years. In 2021, an anonymous voluntary survey was only conducted among 348 young female respondents.Results. Analysis of responses from the survey of adolescents and young girls conducted in 2014 shows an extremely low level of awareness of the emergency contraception methods among respondents in both groups. Thus, 211/265 (79.62%) in the group of adolescent girls and 201/312 (64.42%) young women did not know anything about the emergency contraception methods, and 19/312 (6.09%) young women and 9/265 (3.40%) adolescent girls claimed knowledge of the possibilities of emergency contraception using Escapelle. The analysis of a similar survey conducted in 2021 showed that young women’s awareness of modern emergency contraceptive methods had increased. Thus, less than half of 168/348 (48.28%) participants did not know anything about the emergency contraception methods in 2021, and 117/348 (33.62%) respondents were aware of Escapelle, which was 5.5 times more compared with those of 2014.Conclusions. The results of two surveys we conducted reveal insufficient awareness of the emergency contraceptive methods among young women.
SEREBRAL PALSİ’Lİ ÇOCUĞA SAHİP ANNELERE VERİLEN EGZERSİZ VE POSTÜR EĞİTİMİNİN ANNELERİN KAS İSKELET SİSTEMİ AĞRISI ÜZERİNE ETKİSİ
Authors: AKŞİMŞEK Gamze Polen , TAHRAN Özge , OKUDAN Begüm , AZİM REZAEİ Derya , YELDAN İpek 
Published: April 2022

Amaç: Serebral Palsi (SP)’li çocuğa sahip annelere verilen egzersiz ve postür eğitiminin kas iskelet sistemi ağrıları üzerine etkisini araştırmaktı.
Yöntem: Tüm tiplerdeki SP’li çocuğa sahip anneler (18-55 yaş) randomize olarak eğitim grubu (n=30) ve kontrol grubu (n=30) olmak üzere iki gruba ayrıldı. Değerlendirmelerde Görsel Analog Skalası ve Genişletilmiş Nordik Kas İskelet Sistemi Anketi kullanıldı. Eğitim grubundaki annelere fizyoterapist tarafından egzersiz ve postür eğitimi yüz yüze 60 dakika süreyle 1 kez verildi ve 6 hafta boyunca uzaktan takip edildi.
Sonuçlar: Ağrı şiddeti eğitim öncesinde kontrol grubunda 5,50±1,25; eğitim grubunda 6,26±1,92 idi ve aralarında istatiksel fark yoktu. Eğitim sonrasında kontrol grubunun ağrı şiddeti 5,80±0,88’e yükselirken; eğitim grubunda 3,90±1,29’a azaldı ve gruplar arasında anlamlı fark vardı (p=0,001). Eğitim grubunda eğitim öncesi ve sonrasında yapılan grup içi analizde ağrı şiddetinde (p=0,001) anlamlı fark vardı. Eğitim sonrasında eğitim grubunun son 7 güne ait ağrı dağılımında boyun (%6,7), omuz (%12,3) ve sırt (%16,6) bölgelerinde azalma görüldü.
Tartışma: SP’li çocuğa sahip annelere verilen yüz yüze postür ve egzersiz eğitiminin uzaktan takibinin annelerin ağrı şiddetinin ve boyun, omuz ile sırt bölgelerindeki ağrı dağılımlarının azalttığı ortaya konmuştur.
Assessment of groundwater arsenic contamination using machine learning in Varanasi, Uttar Pradesh, India
Authors: Kumar S. , Pati J. 
Published: April 2022

Abstract
This paper presents a machine learning approach for classification of arsenic (As) levels as safe and unsafe in groundwater samples collected from the Indo-Gangetic region. As water is essential for sustaining life, heavy metals like arsenic pose a public health concern. In this study, various tree-based machine learning models namely Random Forest, Optimized Forest, CS Forest, SPAARC, and REP Tree algorithms have been applied to classify water samples. As per the guidelines of the World Health Organization (WHO), the arsenic concentration in water should not exceed 10 μg/L. The groundwater quality parameter was ranked using a classifier attribute evaluator for training and testing the models. Parameters obtained from the confusion matrix, such as accuracy, precision, recall, and FPR, were used to analyze the performance of models. Among all models, Optimized Forest outperforms other classifier as it has a high accuracy of 80.64%, a precision of 80.70%, recall of 97.87%, and a low FPR of 73.33%. The Optimized Forest model can be used to test new water samples for classification of arsenic in groundwater samples.
Global Scientific Research Landscape on Medical Informatics From 2011 to 2020: Bibliometric Analysis
Authors: He Xuefei , Peng Cheng , Xu Yingxin , Zhang Ye , Wang Zhongqing 
Published: April 2022

Background
With the emerging information and communication technology, the field of medical informatics has dramatically evolved in health care and medicine. Thus, it is crucial to explore the global scientific research landscape on medical informatics.

Objective
This study aims to present a visual form to clarify the overall scientific research trends of medical informatics in the past decade.

Methods
A bibliometric analysis of data retrieved and extracted from the Web of Science Core Collection (WoSCC) database was performed to analyze global scientific research trends on medical informatics, including publication year, journals, authors, institutions, countries/regions, references, and keywords, from January 1, 2011, to December 31, 2020.

Results
The data set recorded 34,742 articles related to medical informatics from WoSCC between 2011 and 2020. The annual global publications increased by 193.86% from 1987 in 2011 to 5839 in 2020. Journal of Medical Internet Research (3600 publications and 63,932 citations) was the most productive and most highly cited journal in the field of medical informatics. David W Bates (99 publications), Harvard University (1161 publications), and the United States (12,927 publications) were the most productive author, institution, and country, respectively. The co-occurrence cluster analysis of high-frequency author keywords formed 4 clusters: (1) artificial intelligence in health care and medicine; (2) mobile health; (3) implementation and evaluation of electronic health records; (4) medical informatics technology application in public health. COVID-19, which ranked third in 2020, was the emerging theme of medical informatics.

Conclusions
We summarize the recent advances in medical informatics in the past decade and shed light on their publication trends, influential journals, global collaboration patterns, basic knowledge, research hotspots, and theme evolution through bibliometric analysis and visualization maps. These findings will accurately and quickly grasp the research trends and provide valuable guidance for future medical informatics research.
Usability Issues in Evidence-Based Psychosocial Interventions and Implementation Strategies: Cross-project Analysis
Authors: Munson Sean A , Friedman Emily C , Osterhage Katie , Allred Ryan , Pullmann Michael D , Areán Patricia A , Lyon Aaron R ,   UW ALACRITY Center Researchers
Published: April 2022

Background
People often prefer evidence-based psychosocial interventions (EBPIs) for mental health care; however, these interventions frequently remain unavailable to people in nonspecialty or integrated settings, such as primary care and schools. Previous research has suggested that usability, a concept from human-centered design, could support an understanding of the barriers to and facilitators of the successful adoption of EBPIs and support the redesign of EBPIs and implementation strategies.

Objective
This study aimed to identify and categorize usability issues in EBPIs and their implementation strategies.

Methods
We adapted a usability issue analysis and reporting format from a human-centered design. A total of 13 projects supported by the National Institute of Mental Health—funded Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness Center at the University of Washington used this format to describe usability issues for EBPIs and implementation strategies with which they were working. Center researchers used iterative affinity diagramming and coding processes to identify usability issue categories. On the basis of these categories and the underlying issues, we propose heuristics for the design or redesign of EBPIs and implementation strategies.

Results
The 13 projects reported a total of 90 usability issues, which we categorized into 12 categories, including complex and/or cognitively overwhelming, required time exceeding available time, incompatibility with interventionist preference or practice, incompatibility with existing workflow, insufficient customization to clients/recipients, intervention buy-in (value), interventionist buy-in (trust), overreliance on technology, requires unavailable infrastructure, inadequate scaffolding for client/recipient, inadequate training and scaffolding for interventionists, and lack of support for necessary communication. These issues range from minor inconveniences that affect a few interventionists or recipients to severe issues that prevent all interventionists or recipients in a setting from completing part or all of the intervention. We propose 12 corresponding heuristics to guide EBPIs and implementation strategy designers in preventing and addressing these usability issues.

Conclusions
Usability issues were prevalent in the studied EBPIs and implementation strategies. We recommend using the lens of usability evaluation to understand and address barriers to the effective use and reach of EBPIs and implementation strategies.

International Registered Report Identifier (IRRID)
RR2-10.2196/14990
A Gestalt Therapy Treatment Approach for Addictions: "Multiphasic Transformation Process"
Authors: MATZKO HELGA M. GENANNT , Matzko Helga M. Gennant 
Published: April 2022

Abstract
Traditional treatments of addictions developed over the past 40 years have been based on various theoretical models of development. None of these address the complexities of addictions' impact on all facets of the functional self. This article presents a flexible "multiphasic transformation process" (MPTP) approach valuing Gestalt therapy principles and considers as its basis the "cycle of experience" as it relates to the progressive nature of growth and change in the process of transformation. The meaning of addiction and addict will be redefined from this new MPTP perspective. Case materials will illustrate the treatment process, and appropriate therapeutic tasks will be suggested for each phase.
The Therapeutic Process With Children and Adolescents
Authors: OAKLANDER VIOLET 
Published: April 2022

Abstract
A process of therapy has emerged through analysis of the author's work with children and adolescents over a span of 32 years. This process fits organically with the philosophy, theory, and practice of Gestalt therapy, beginning with the prerequisite of the relationship between client and therapist. The role of contact and its connection to resistance is examined as particularly applied to the specific characteristics of children. The author has found that the continuous strengthening of the child's inner support structure in the course of therapy is fundamental to the child's ability to work through deep-seated, blocked emotions. Therefore, enhancing the child's sense of self is a crucial step toward healthy emotional expression and optimum growth and development. The focus on self-enhancement through specific experiences inherent in child development is an intrinsic part of psychotherapy with children and adolescents. Even the task of helping the child feel safe and comfortable with expressing feelings requires its own sequence. The author discusses a method for helping the child become self-nurturing, an important component of the therapeutic process and one often neglected in Gestalt therapy, yet particularly critical to the child who has suffered trauma. Finally, the therapeutic process concludes with termination, never actually a final step since children can only deal with specific issues in accordance with their particular developmental stage.
Risk Assessment of Failures in Generic Drug Development and Approval Procedure under Competitive Generic Drug Therapy and Patent Challenge Exclusivities Provided by the United States Food and Drug Administration
Authors: Reddy M Vivek , Ganesh GNK , Babu B , Jagadeesan Ramesh , MR Praharsh Kumar 
Published: April 2022

Abstract

Objective: The United States Food and Drug Administration implemented two exclusivity programs Competitive generic therapy and Patent Challenge exclusivity to develop generic drugs, which provide a 180-day monopoly market for first generic applicants in the United States of America. The aim of the present study is to find the root cause of failures in developing and filing the first generic drugs under these exclusivities and to compare both the exclusivities to find the merits and demerits.

Methods: We used descriptive statistics for data analysis of both the exclusivities and Risk assessment was conducted on 14 industries to find the root cause of failures in every stage of the approval procedure by FMECA (Failure mode, Effects and Criticality Analysis).

Results: We found 44% of rejections in competitive generic therapy drugs and 30% of rejections in patent challenge exclusivity drugs. The risk analysis conducted on failures found that, in drug selection, 6% of failures are occurred due to rare diseases. In drug development, 9% of failures are occurred due to formulation failures. In pre-approval, 10% of failures are occurred due to secondary patents. In post-approval, 6% of failures are occurred due to product changes after approval.

Conclusion: We hope this study can give an idea for small and medium companies in developing countries for the early development of generic drugs for life-threatening diseases.
Cashless payment system and Covid-19 on the example of the Czech Republic
Authors: Schlossberger Otakar , Soldánová Marcela 
Published: April 2022

Abstract
The paper deals with cashless payments during the pandemic situation caused by Covid-19. The aim of the paper will be to use the method of analysis and comparison of selected data to answer the following research question: Has the pandemic caused by Covid-19 contributed to increasing the share of non-cash payments? The authors base their research on the hypothesis that “the pandemic period had a significant impact on the development of cashless payments”. From the performed research, the authors came to the conclusion that based on the methods used, the established hypothesis was not confirmed and the answer to the research question had to be given in the negative.