bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation and Potential Uses of Site Investigation Soil Contamination Data Submitted to Uk Local Government
Authors: Hellawell Emma E. , Hughes Susan J. 
Published: May 2022

AbstractThere has been considerable brownfield development in the UK since 2000 due to increasing demand for new housing, combined with local opposition to building on greenbelt land. To facilitate this, extensive site investigations have been carried out and the reports submitted to local government as part of the planning process. This research investigates whether this largely untapped resource of site investigation data can be used to improve understanding of potentially toxic elements (PTE) and persistent organic pollutants (POP) at a local scale. The PTE/POP data were extracted from 1707 soil samples across 120 brownfield sites in an urban/suburban region. The samples were analysed to determine the effect of site location, historical use and site age on PTE/POP concentrations. Box plots indicating statistical results together with GIS maps of PTE/POP sample data provided the optimal visualisation of results. The dataset was shown to be a valuable resource, although further exploitation would be enhanced by digitisation of the submitted data. The paper explores potential applications of this data, including background concentrations and anthropogenic enrichment factors for PTE/POP. The results were summarised in a table for the PTE/POP and a preliminary risk assessment process chart to inform developers/regulators on potential PTE/POP levels on brownfield sites on a local scale. This information could focus design and resources for developers for site investigations and risk assessments and improve planning and regulatory guidance. The lack of predictability in PTE/POP results across sites have emphasised the ongoing need for intrusive site investigation on new brownfield developments.
Preoperative Anxiety is Associated With Postoperative Complications in Vascular Surgery: A Cross‐Sectional Study
Authors: Jovanovic Ksenija , Kalezic Nevena , Sipetic Grujicic Sandra , Zivaljevic Vladan , Jovanovic Milan , Kukic Biljana , Trailovic Ranko , Zlatanovic Petar , Mutavdzic Perica , Tomic Ivan , Ilic Nikola , Davidovic Lazar 
Published: May 2022

AbstractBackgroundPreoperative anxiety is associated with increased morbidity and/or mortality in surgical patients. This study investigated the incidence, predictors, and association of preoperative anxiety with postoperative complications in vascular surgery.MethodsConsecutive patients undergoing aortic, carotid, and peripheral artery surgery, under general and regional anesthesia, from February until October 2019 were included in a cross‐sectional study. Anesthesiologists assessed preoperative anxiety using a validated Serbian version of the Amsterdam Preoperative Anxiety and Information Scale. Patients were divided into groups with low/high anxiety, both anesthesia‐ and surgery‐related. Statistical analysis included multivariate linear logistic regression and point‐biserial correlation.ResultsOf 402 patients interviewed, 16 were excluded and one patient refused to participate (response rate 99.7%). Out of 385 patients included (age range 39–86 years), 62.3% had previous surgery. High‐level anesthesia‐ and surgery‐related anxieties were present in 31.2 and 43.4% of patients, respectively. Independent predictors of high‐level anesthesia‐related anxiety were having no children (OR = 0.443, 95% CI: 0.239–0.821, p = 0.01), personal bad experiences with anesthesia (OR = 2.294, 95% CI: 1.043–5.045, p = 0.039), and time since diagnosis for ≥ 4 months (OR = 1.634, 95% CI: 1.023–5.983, p = 0.04). The female sex independently predicted high‐level surgery‐related preoperative anxiety (OR = 2.387, 95% CI: 1.432–3.979, p = 0.001). High‐level anesthesia‐related anxiety correlated with postoperative mental disorders (rpb = 0.193, p = 0.001) and pulmonary complications (rpb = 0.104, p = 0.042). Postoperative nausea (rpb = 0.111, p = 0.03) and postoperative mental disorders (rpb = 0.160, p = 0.002) correlated with high‐level surgery‐related preoperative anxiety.ConclusionsSince preoperative anxiety affects the postoperative course and almost every third patient experiences anxiety preoperatively, routine screening might be recommended in vascular surgery.
Species-specific elementomes for scleractinian coral hosts and their associated Symbiodiniaceae
Authors: Grima Amanda J. , Clases David , Gonzalez de Vega Raquel , Nitschke Matthew R. , Goyen Samantha , Suggett David J. , Camp Emma F. 
Published: May 2022

AbstractIncreasing anthropogenic pressure on coral reefs is creating an urgent need to understand how and where corals can proliferate both now and under future scenarios. Resolving environmental limits of corals has progressed through the accurate identification of corals’ ‘realised ecological niche’. Here we expand the ecological niche concept to account for corals’ ‘biogeochemical niche’ (BN), defined as the chemical space in which a coral is adapted to survive, and which is identifiable by a unique quantity and proportion of elements (termed “elementome”). BN theory has been commonly applied to other taxa, successfully predicting species distributions and stress responses by their elementomes. Here, we apply the BN theory to corals for the first time, by using dry combustion and inductively coupled plasma–mass spectrometry (ICP-MS) to determine five key macronutrients and thirteen trace elements of four diverse scleractinian coral species from the Great Barrier Reef (GBR): Acropora hyacinthus; Echinopora lamellosa; Pocillopora cf. meandrina; and Pocillopora cf. verrucosa. The elementomes were investigated in both host and Symbiodiniaceae, and the latter had the highest elemental concentrations (except molybdenum). Each coral species associated with distinct members of the genus Cladocopium (determined by ITS2 analysis) with photo-physiological data suggesting specialisation of Cladocopium functional biology. Distinct endosymbiont community structure and functioning between corals with different elementomes confirms that BN theory holds as metabolic compatibility alters across host–symbiont associations. Additional work is needed to understand the plasticity of coral elementomes, and in turn BN, over space and time to aid predictions on coral distribution and survival with environmental change.
Unterstützungsbedarfe pflegeempfangender Menschen
Authors: Strube-Lahmann Sandra , Müller Franziska , Liersch-Mazan Daniela , Haink Michele , Müller-Werdan Ursula , Lahmann Nils A. 
Published: May 2022

Zusammenfassung
Hintergrund
Pflegeempfangende und deren Angehörige haben in Deutschland seit 2009 einen gesetzlichen Anspruch auf eine Pflegeberatung. Um Pflegeberatende angemessen auf aktuelle Beratungsbedarfe vorzubereiten, sind dafür zunächst die bestehenden Anliegen zu erfassen. Ziel der Studie war es, die unterschiedlichen Bedarfe von Pflegeempfangenden und deren Angehörigen zu ermitteln.

Methodik
Es erfolgte eine Online-Befragung von Pflegeberatenden mittels standardisiertem Fragebogen. Die Ausprägung des allgemeinen Beratungsbedarfs von Pflegeempfangenden und Angehörigen wurde mittels 10-stufiger Skala (1 [gering] bis 10 [hoch]) erhoben. Über eine 5‑stufige Likert-Skala wurde die Höhe vorliegender Beratungsbedarfe zu 16 Themenschwerpunkten bewertet. Mittels „classification and regression trees“ (CRT) und „random forest“ wurde der Zusammenhang zwischen den einzelnen Themenschwerpunkten und dem allgemeinen Beratungsbedarf analysiert.

Ergebnisse
Der allgemeine Informationsbedarf von Pflegeempfangenden bzw. Angehörigen wurde von den teilnehmenden Pflegeberatern (n = 276) mit MW 7,8 bzw. MW 9,2 eingeschätzt. Bei den Pflegeempfangenden bestand laut CRT der stärkste Zusammenhang zwischen allgemeinem Informationsbedarf und „Wohnraumberatung“, bei den Angehörigen zwischen allgemeinem Informationsbedarf und „Sozialrechtliche[n] Aspekte[n], Ansprüche[n], Leistungen“.

Diskussion
Der allgemeine Informationsbedarf von Pflegeempfangenden und Angehörigen wird als sehr hoch eingeschätzt. Dennoch lassen sich Unterschiede feststellen. Daher erscheint es notwendig, Pflegeberatungen nach den gruppenspezifischen Beratungsbedarfen auszurichten.
Cerebral oxygen saturation as outcome predictor after transfemoral transcatheter aortic valve implantation
Authors: Seppelt Philipp C. , Mas-Peiro Silvia , Van Linden Arnaud , Iken Sonja , Zacharowski Kai , Walther Thomas , Fichtlscherer Stephan , Vasa-Nicotera Mariuca 
Published: May 2022

Abstract
Background
Cerebral oxygen saturation (ScO2) can be measured non-invasively by near-infrared spectroscopy (NIRS) and correlates with cerebral perfusion. We investigated cerebral saturation during transfemoral transcatheter aortic valve implantation (TAVI) and its impact on outcome.

Methods and results
Cerebral oxygenation was measured continuously by NIRS in 173 analgo-sedated patients during transfemoral TAVI (female 47%, mean age 81 years) with self-expanding (39%) and balloon-expanding valves (61%). We investigated the periprocedural dynamics of cerebral oxygenation. Mean ScO2 at baseline without oxygen supply was 60%. During rapid ventricular pacing, ScO2 dropped significantly (before 64% vs. after 55%, p < 0.001). ScO2 at baseline correlated positively with baseline left-ventricular ejection fraction (0.230, p < 0.006) and hemoglobin (0.327, p < 0.001), and inversely with EuroSCORE-II ( − 0.285, p < 0.001) and length of in-hospital stay ( − 0.229, p < 0.01). Patients with ScO2 < 56% despite oxygen supply at baseline had impaired 1 year survival (log-rank test p < 0.01) and prolonged in-hospital stay (p = 0.03). Furthermore, baseline ScO2 was found to be a predictor for 1 year survival independent of age and sex (multivariable adjusted Cox regression, p = 0.020, hazard ratio (HR 0.94, 95% CI 0.90–0.99) and independent of overall perioperative risk estimated by EuroSCORE-II and hemoglobin (p = 0.03, HR 0.95, 95% CI 0.91–0.99).

Conclusions
Low baseline ScO2 not responding to oxygen supply might act as a surrogate for impaired cardiopulmonary function and is associated with worse 1 year survival and prolonged in-hospital stay after transfemoral TAVI. ScO2 monitoring is an easy to implement diagnostic tool to screen patients at risk with a potential preserved recovery and worse outcome after TAVI.

Graphical abstract
Asymptotic Analysis of q-Recursive Sequences
Authors: Heuberger Clemens , Krenn Daniel , Lipnik Gabriel F. 
Published: May 2022

AbstractFor an integer$$q\ge 2$$q≥2, aq-recursive sequence is defined by recurrence relations on subsequences of indices modulo some powers of q. In this article,q-recursive sequences are studied and the asymptotic behavior of their summatory functions is analyzed. It is shown that everyq-recursive sequence isq-regular in the sense of Allouche and Shallit and that aq-linear representation of the sequence can be computed easily by using the coefficients from the recurrence relations. Detailed asymptotic results forq-recursive sequences are then obtained based on a general result on the asymptotic analysis ofq-regular sequences.Three particular sequences are studied in detail: We discuss the asymptotic behavior of the summatory functions ofStern’s diatomic sequence,the number of non-zero elements in some generalized Pascal’s triangle andthe number of unbordered factors in the Thue–Morse sequence.For the first two sequences, our analysis even leads to precise formulæ without error terms.
Fluorescence angiography likely protects against anastomotic leak in colorectal surgery: a systematic review and meta-analysis of randomised controlled trials
Authors: Meyer Jeremy , Joshi Heman , Buchs Nicolas C. , Ris Frédéric , Davies Justin 
Published: May 2022

Abstract
Objective
Observational studies have shown that fluorescence angiography (FA) decreases the incidence of anastomotic leak (AL) in colorectal surgery, but high-quality pooled evidence was lacking. Therefore, we aimed at confirming this preliminary finding using a systematic review and meta-analysis of randomised controlled trials (RCTs) in the field.

Methods
MEDLINE, Embase and CENTRAL were searched for RCTs assessing the effect of intra-operative FA versus standard assessment of bowel perfusion on the incidence of AL of colorectal anastomosis. The systematic review complied with the PRISMA 2020 and AMSTAR2 recommendations and was registered in PROSPERO. Pooled relative risk (RR) and pooled risk difference (RD) were obtained using models with random effects. Heterogeneity was assessed using the Q-test and quantified using the I2 value. Certainty of evidence was assessed using the GRADE Pro tool.

Results
One hundred and eleven articles were screened, 108 were excluded and three were kept for inclusion. The three included RCTs compared assessment of the perfusion of the bowel during creation of a colorectal anastomosis using FA versus standard practice. In meta-analysis, FA was significantly protective against AL (3 RCTs, 964 patients, RR: 0.67, 95% CI: 0.46 to 0.99, I2: 0%, p = 0.04). The RD of AL was non-significantly decreased by 4 percentage points (95%CI: − 0.08 to 0, I2: 8%, p = 0.06) when using FA. Certainty of evidence was considered as moderate.

Conclusion
The effect of FA on prevention of AL in colorectal surgery exists but is potentially of small magnitude. Considering the potential magnitude of effect of FA, we advise that future RCTs have an adequate sample size, include a cost-benefit analysis of the technique and better define the subpopulation who could benefit from FA.

Graphical abstract
Cardio-oncology in Austria: cardiotoxicity and surveillance of anti-cancer therapies
Authors: Bergler-Klein Jutta , Rainer Peter P. , Wallner Markus , Zaruba Marc-Michael , Dörler Jakob , Böhmer Armin , Buchacher Tamara , Frey Maria , Adlbrecht Christopher , Bartsch Rupert , Gyöngyösi Mariann , Fürst Ursula-Maria 
Published: May 2022

SummarySurvival in cancer is continuously improving due to evolving oncological treatment. Therefore, cardiovascular short-term and long-term side effects gain crucial importance for overall outcome. Cardiotoxicity not only presents as heart failure, but also as treatment-resistant hypertension, acute coronary ischemia with plaque rupture or vasospasm, thromboembolism, arrhythmia, pulmonary hypertension, diastolic dysfunction, acute myocarditis and others. Recent recommendations have proposed baseline cardiac risk assessment and surveillance strategies. Major challenges are the availability of monitoring and imaging resources, including echocardiography with speckle tracking longitudinal strain (GLS), serum biomarkers such as natriuretic peptides (NT-proBNP) and highly sensitive cardiac troponins. This Austrian consensus encompasses cardiotoxicity occurrence in frequent antiproliferative cancer drugs, radiotherapy, immune checkpoint inhibitors and cardiac follow-up considerations in cancer survivors in the context of the Austrian healthcare setting. It is important to optimize cardiovascular risk factors and pre-existing cardiac diseases without delaying oncological treatment. If left ventricular ejection fraction (LVEF) deteriorates during cancer treatment (from >10% to <50%), or myocardial strain decreases (>15% change in GLS), early initiation of cardioprotective therapies (angiotensin-converting enzyme inhibitors, angiotensin or beta receptor blockers) is recommended, and LVEF should be reassessed before discontinuation. Lower LVEF cut-offs were recently shown to be feasible in breast cancer patients to enable optimal anticancer treatment. Interdisciplinary cardio-oncology cooperation is pivotal for optimal management of cancer patients.
Financial difficulties in breast cancer survivors with and without migration background in Germany—results from the prospective multicentre cohort study BRENDA II
Authors: Riccetti N. , Felberbaum R. , Flock F. , Kühn T. , Leinert E. , Schwentner L. , Singer S. , Taylor K. , Wöckel A. , Janni W. 
Published: May 2022

Abstract
Purpose
We aimed to explore the trajectory of financial difficulties among breast cancer survivors in the German health system and its association with migration background.

Methods
In a multicentre prospective study, breast cancer survivors were approached four times (before surgery, before and after adjuvant therapy, five years after surgery) and asked about their migration history and financial difficulties.
Migrants were defined as born/resided outside Germany or having citizenship/nationality other than German. Financial difficulties were ascertained with the financial difficulties item of the European Organisation for Research and Treatment of Cancer Core Instrument (EORTC QLQ-C30) at each time-point (cut-off > 17). Financial difficulties were classified in trajectories: always (every time-point), never (no time-point), initial (first, not fourth), delayed (only fourth), and acquired (second and/or third, not first).
A logistic regression was conducted with the trajectories of financial difficulties as outcome and migration background as exposure. Age, trends in partnership status, and educational level were considered as confounders.

Results
Of the 363 participants included, 49% reported financial difficulties at at least one time-point.
Financial difficulties were reported always by 7% of the participants, initially by 5%, delayed by 10%, and acquired by 21%.
Migrants were almost four times more likely to report delayed (odds ratio [OR] = 3.7; 95% confidence interval [CI] 1.3, 10.5) or acquired (OR = 3.6; 95% CI 1.6, 8.4) financial difficulties compared to non-migrant participants.

Conclusion
Survivors with a migration background are more likely to suffer from financial difficulties, especially in later stages of the follow-up. A linguistically/culturally competent active enquiry about financial difficulties and information material regarding supporting services/insurances should be considered.
Exploring the experiences and psychosocial support needs of informal carers of men with breast cancer: a qualitative study
Authors: Herring Beth , Lewis-Smith Helena , Paraskeva Nicole , Harcourt Diana 
Published: May 2022

Abstract
Purpose
The provision of practical and emotional support for men who have been diagnosed with breast cancer in the UK falls primarily on their partners, close family members or friends. However, informal carers’ experiences are omitted from the research literature. Therefore, the present study aimed to explore the care-giving experiences of informal carers (ICs) of men with breast cancer in the UK and identify psychosocial support needs and preferences.

Methods
Semi-structured interviews, conducted on the telephone or via online video calls, explored ICs’ experiences of providing support, the psychosocial issues they faced and the impact of the illness on themselves and their relationship with the patient. They were also asked about any support previously offered to them, in addition to their support preferences. Twelve ICs participated (11 females, 1 male), and 9 were spouses. Interview transcripts were analysed with reflexive thematic analysis using NVIVO software.

Results
Four key themes were identified: “The impact of caring”, “Lack of awareness”, “Isolated and alone” and “Making a difference”.

Conclusions
The physical, emotional, financial and social impact of providing emotional and practical care and support for a man diagnosed with breast cancer can be considerable. ICs may experience significant levels of distress and often feel isolated. Greater awareness and more research is needed to better understand the psychosocial impact and support needs for ICs of men with breast cancer. There is an evident necessity to address their information needs and offer sources of support throughout the cancer journey.
Estimation of missing air pollutant data using a spatiotemporal convolutional autoencoder
Authors: Wardana I Nyoman Kusuma , Gardner Julian W. , Fahmy Suhaib A. 
Published: May 2022

AbstractA key challenge in building machine learning models for time series prediction is the incompleteness of the datasets. Missing data can arise for a variety of reasons, including sensor failure and network outages, resulting in datasets that can be missing significant periods of measurements. Models built using these datasets can therefore be biased. Although various methods have been proposed to handle missing data in many application areas, more air quality missing data prediction requires additional investigation. This study proposes an autoencoder model with spatiotemporal considerations to estimate missing values in air quality data. The model consists of one-dimensional convolution layers, making it flexible to cover spatial and temporal behaviours of air contaminants. This model exploits data from nearby stations to enhance predictions at the target station with missing data. This method does not require additional external features, such as weather and climate data. The results show that the proposed method effectively imputes missing data for discontinuous and long-interval interrupted datasets. Compared to univariate imputation techniques (most frequent, median and mean imputations), our model achieves up to 65% RMSE improvement and 20–40% against multivariate imputation techniques (decision tree, extra-trees, k-nearest neighbours and Bayesian ridge regressors). Imputation performance degrades when neighbouring stations are negatively correlated or weakly correlated.
Schmerzhafte Muskel-Skelett-Veränderungen bei Kindern mit neuromotorischen Erkrankungen (Teil 1)
Authors: Strobl Walter Michael 
Published: May 2022

ZusammenfassungBei allen angeborenen und erworbenen Erkrankungen des Gehirns, des Rückenmarks, der Nerven und der Muskeln können Veränderungen der Bewegung und Haltung, Sensorik und Motorik beobachtet werden. Je nach Dauer der Störung entwickeln sich reversible und/oder irreversible Veränderungen der Bewegungsfunktion und Form der Bewegungsorgane, die biomechanischen Gesetzmäßigkeiten folgen.Da diese Muskel-Skelett-Veränderungen sehr häufig für unterschätzte Schmerzen, Immobilität, mangelnde soziale Teilhabe und damit einer massiven Einschränkung der Lebensqualität verantwortlich sind, ist die detaillierte Kenntnis der funktionellen Anatomie und dieser Gesetzmäßigkeiten als Basis einer erfolgreichen Vorbeugung und Behandlung erforderlich.Den wichtigsten Stellenwert in der Frühdiagnostik bildet das rechtzeitige Erkennen von Kräfteungleichgewichten an Gelenken, von veränderten Hebelarmen der Muskulatur, von chronischen Schmerzen als Zeichen einer reaktiven Überlastung und von beginnenden Bewegungseinschränkungen. Screening-Programme sollten entwickelt werden, die alle Störungsbilder umfassen und einfach im klinischen Alltag implementiert werden können. Je früher Prävention und Behandlung dieser neuroorthopädischen Probleme bei chronischen neuromotorischen Erkrankungen in jeder Altersgruppe beginnen, umso erfolgreicher können Fehlentwicklungen sowie irreversible sekundäre Schäden, strukturelle Veränderungen, Fehlstellungen, Kontrakturen, (Sub‑)Luxationen, Funktionsverlust, Immobilität und Behinderungen vermieden werden.In diesem ersten Teil der Arbeit wird die Relevanz und Pathophysiologie dieser Muskel-Skelett-Veränderungen beschrieben.