bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mucinous cystic neoplasm of the liver with polypoid nodule prolapsing into the bile duct: a case report and review of literature
Authors: Fukui Yasuhiro , Murata Akihiro , Shimizu Sadatoshi , Sai Kayo , Okada Takuma , Tashima Tetsuzo , Kodai Shintaro , Kanazawa Akishige , Okuno Takahiro 
Published: September 2022

Abstract
Background
Mucinous cystic neoplasm of the liver (MCN-L) is a rare cystic tumor as defined by the 2010 World Health Organization classification. MCN-L usually does not communicate with or grow into the bile duct. Herein, we present a rare case of MCN-L with a polypoid nodule protruding into the bile duct.

Case presentation
A 69-year-old woman was referred to our hospital for elevated serum liver enzyme levels and obstructive jaundice. The patient also complained of abdominal pain in the right hypochondriac region. Abdominal ultrasonography showed a cystic lesion in segment 4 (S4) of the liver. Computed tomography revealed a 4-cm multilocular cystic lesion with a thick wall and multiple septal formations, showing a cyst-in-cyst appearance in S4. Endoscopic retrograde cholangiography showed a contrast defect between the left hepatic duct and the common bile duct, which was suspected to be a nodular lesion in the bile duct. Bile cytology and biopsy of the nodular lesion showed no malignant findings. Based on these findings, the differential diagnosis in this patient included intraductal papillary neoplasm of the bile duct and MCN-L, which had malignant potential. The patient underwent left hemihepatectomy, including caudate lobe excision with bile duct resection and right hepatocholangiojejunostomy. Macroscopic findings showed a 40 × 29 mm multilocular cystic lesion with a polypoid nodule that protruded into the left intrahepatic bile duct. As an ovarian-like stroma was observed in both cystic and polypoid lesions microscopically, the histopathological diagnosis was MCN-L. The postoperative course was uneventful, and the patient was discharged 24 days after surgery. The patient is currently alive without recurrence 22 months after the surgery.

Conclusion
Although MCN-L rarely communicates with the bile duct, it is necessary to consider that MCN-L could grow into the bile duct, occasionally causing obstructive jaundice.
Sudden hemothorax as a rare initial manifestation of bronchiectasis under a direct oral anticoagulant
Authors: Nakayama Hikaru , Uebayashi Asuka , Yagi Shota , Iizuka Shuhei , Otsuki Yoshiro , Nakamura Toru 
Published: September 2022

Abstract
Background
A hemothorax as the initial manifestation of bronchiectasis is extremely rare. We report a case of a sudden hemothorax due to exacerbation of clinically latent bronchiectasis under a direct oral anticoagulant.

Case presentation
A 77-year-old woman presented with chest pain and a fever noted since the day before. She had stage G3 chronic kidney disease and received edoxaban for paroxysmal atrial fibrillation. She had no history of trauma or respiratory symptoms. A chest computed tomography revealed a mass with a surrounding opacity in the right lower lobe with a pleural effusion. Conservative treatment was chosen because of the stable vital signs and her respiratory condition. Her oxygen saturation dropped 7 h later with progressive anemia. Repeated chest computed tomography showed a worsening pulmonary opacity and pleural effusion. She underwent a right lower lobectomy successfully. The histopathological findings suggested that the preceding infection of the subpleural focal bronchiectasis caused the bleeding. In addition, a steep caliber change between the subpleural focal bronchiectasis and proximal normal branch may have caused an intraluminal pressure gradient resulting in a peripheral discharge causing a pleural rupture with a hemothorax.

Conclusion
The sudden hemothorax could have been the initial manifestation of bronchiectasis. Particular attention should be paid to peripherally localized bronchiectasis even if it is without any clinical symptoms, especially in patients with a comorbidity such as a susceptibility to infections and the use of direct oral anticoagulants.
Is colonial heritage negative or not so much? Debating heritage discourses and selective interpretation of Kulangsu, China
Authors: Wei Ran , Wang Fang 
Published: September 2022

AbstractHeritage is in essence dissonant, especially colonial heritage in postcolonial nations. Via questionnaire surveys and interviews, this study investigates Kulangsu in Xiamen, China, a colonial heritage site mainly developed in the 19th and 20th centuries, to unveil the local government’s authorised heritage discourse (AHD) of the site and how tourists perceive the colonial past of Kulangsu and construct their own heritage discourse(s). Results show that, when considering the colonial history of the site, neither the AHD promoted by the authorities nor the tourists’ lay discourses are necessarily negative. However, tension implicitly arises between the tourists’ demand for comprehensive heritage information and the authorities’ selective interpretation of the site. Although the AHD affects lay discourses to some extent, most tourists expect the authorities to present more complete and neutral information about heritage so they can reflect and forge their own conception of colonial legacies. From a critical heritage studies perspective, this tension reflects the power imbalance between the authorities and the tourists and reminds the authorities and heritage experts to rethink heritage tourism and conservation in terms of heritage interpretation. This paper, therefore, calls for additional reflection on the legitimacy of selective interpretation, which implicates a complex process of intricate reasoning that is underpinned by the power imbalance between the authorities and the tourists, ultimately resulting in an AHD.
Tri-linear representations for the Laser Interferometer Space Antenna
Authors: Andersson Fredrik , Riegger Franziska , Ferraioli Luigi , Giardini Domenico , Robertsson Johan 
Published: September 2022

Abstract
The Laser Interferometer Space Antenna (LISA) is a space-borne observatory of gravitational waves to be launched by ESA and NASA in the 2030s. Interferometric measurements are made between three spacecraft orbiting the Sun. The measurements are dependent on the geometric information due to the relative locations between the spacecraft as well as the intrinsic parameters of the astrophysical objects that generate the gravitational waves. We show that the measurements of mildly chirping gravitational waves can be approximated by means of a tri-linear representation, where the geometric information about the location of the observed object as well as that of the spacecraft locations are separated by different factors. We discuss that for low frequencies the relative approximation error is proportional to the square of the signal’s carrier frequency and illustrate this accuracy in numerical experiments. For the sake of illustration, we outline a simple algorithm for extracting parameters from the observed gravitational waves.
Correlation of the Modified Japanese Orthopedic Association With Functional and Quality-of-Life Outcomes After Surgery for Degenerative Cervical Myelopathy: A Quality Outcomes Database Study
Authors: Yee Timothy J. , Upadhyaya Cheerag , Coric Domagoj , Potts Eric A. , Bisson Erica F. , Turner Jay , Knightly Jack J. , Fu Kai-Ming , Foley Kevin T. , Tumialan Luis , Shaffrey Mark E. , Bydon Mohamad , Mummaneni Praveen , Chou Dean , Chan Andrew , Meyer Scott , Asher Anthony L. , Shaffrey Christopher , Gottfried Oren N. , Than Khoi D. , Wang Michael Y. , Buchholz Avery L. , Haid Regis , Park Paul 
Published: September 2022

BACKGROUND:
The modified Japanese Orthopedic Association (mJOA) score is a widely used and validated metric for assessing severity of myelopathy. Its relationship to functional and quality-of-life outcomes after surgery has not been fully described.

OBJECTIVE:
To quantify the association of the mJOA with the Neck Disability Index (NDI) and EuroQol-5 Dimension (EQ-5D) after surgery for degenerative cervical myelopathy.

METHODS:
The cervical module of the prospectively enrolled Quality Outcomes Database was queried retrospectively for adult patients who underwent single-stage degenerative cervical myelopathy surgery. The mJOA score, NDI, and EQ-5D were assessed preoperatively and 3 and 12 months postoperatively. Improvement in mJOA was used as the independent variable in univariate and multivariable linear and logistic regression models.

RESULTS:
Across 14 centers, 1121 patients were identified, mean age 60.6 ± 11.8 years, and 52.5% male. Anterior-only operations were performed in 772 patients (68.9%). By univariate linear regression, improvements in mJOA were associated with improvements in NDI and EQ-5D at 3 and 12 months postoperatively (all P < .0001) and with improvements in the 10 NDI items individually. These findings were similar in multivariable regression incorporating potential confounders. The Pearson correlation coefficients for changes in mJOA with changes in NDI were −0.31 and −0.38 at 3 and 12 months postoperatively. The Pearson correlation coefficients for changes in mJOA with changes in EQ-5D were 0.29 and 0.34 at 3 and 12 months.

CONCLUSION:
Improvements in mJOA correlated weakly with improvements in NDI and EQ-5D, suggesting that changes in mJOA may not be a suitable proxy for functional and quality-of-life outcomes.
Disjunctive Rule Lists
Authors: Ragodos Ronilo , Wang Tong 
Published: September 2022

In this study, we present an interpretable model, disjunctive rule list (DisRL) for regression. This research is motivated by the increasing need for model interpretability, especially in high-stakes decisions such as medicine, where decisions are made on or related to humans. DisRL is a generalized form of rule lists. A DisRL model consists of a list of disjunctive rules embedded in an if-else logic structure that stratifies the data space. Compared with traditional decision trees and other rule list models in the literature that stratify the feature space with single itemsets (an itemset is a conjunction of conditions), each disjunctive rule in DisRL uses a set of itemsets to collectively cover a subregion in the feature space. In addition, a DisRL model is constructed under a global objective that balances the predictive performance and model complexity. To train a DisRL model, we devise a hierarchical stochastic local search algorithm that exploits the properties of DisRL’s unique structure to improve search efficiency. The algorithm adopts the main structure of simulated annealing and customizes the proposing strategy for faster convergence. Meanwhile, the algorithm uses a prefix bound to locate a subset of the search area, effectively pruning the search space at each iteration. An ablation study shows the effectiveness of this strategy in pruning the search space. Experiments on public benchmark datasets demonstrate that DisRL outperforms baseline interpretable models, including decision trees and other rule-based regressors. History: Accepted by J. Paul Brooks, Area Editor for Applications in Biology, Medicine, & Healthcare. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplementary Information [ https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.1242 ] or is available from the IJOC GitHub software repository ( https://github.com/INFORMSJoC ) at [ http://dx.doi.org/10.5281/zenodo.6954927 ].
Fair Integral Network Flows
Authors: Frank András , Murota Kazuo 
Published: September 2022

A strongly polynomial algorithm is developed for finding an integer-valued feasible st-flow of a given flow amount, which is decreasingly minimal on a specified subset F of edges in the sense that the largest flow value on F is as small as possible; within this, the second largest flow value on F is as small as possible; within this, the third largest flow value on F is as small as possible, and so on. A characterization of the set of these st-flows gives rise to an algorithm to compute a cheapest F-decreasingly minimal integer-valued feasible st-flow of given flow amount. Decreasing minimality is a possible formal way to capture the intuitive notion of fairness. Funding: This work was supported by JSPS KAKENHI [Grants JP20K11697, JP26280004] and the National Research, Development, and Innovation Fund of Hungary [Grant NKFI-128673].
Exploring nurses' experiences of caring for patients participating in cancer clinical trials
Authors: Hood Ben 
Published: September 2022

Aims:Drawing on the experiences of cancer research nurses (CRNs) from the Cancer Research UK Excellence in Research Programme, this article aims to provide an insight into managing cancer patients' expectations of participating in clinical trials. It also outlines what CRNs consider are the key elements when supporting patients through side-effect management.Method:Through group work and discussions, CRNs' reflective experiences were captured by workshop facilitators around three topics by exploring nurses' experiences of caring for patients participating in cancer clinical trials. Reflective CRN experiences for each of the three topics were reviewed and themes were developed by the author, who also facilitated this workshop.Results:Developing relationships, patient education and effective communication were all identified as important factors when helping to manage patient expectations and aid side-effect management.Conclusion:The findings, based on CRN experiences, give an understanding of aspects of the role that nurses have within cancer clinical trials, what patient expectations of clinical trial are and strategies on how best to support patients within this area of nursing.
Three-element, self-starting Kerr-lens-modelocked 1-GHz Ti:sapphire oscillator pumped by a single laser diode
Authors: Ostapenko Hanna , Mitchell Toby , Castro-Marin Pablo , Reid Derryck T. 
Published: September 2022

We present a Kerr-lens-modelocked, three-element, diode-pumped Ti:sapphire laser producing 111-fs pulses at a repetition frequency of 1.02 GHz. Self-starting soliton-modelocked operation with an output power of 106 mW was obtained when the laser was pumped at 1.0 W with a single 527-nm laser diode. The output exhibits a relative intensity noise of 0.06% (1 Hz – 1 MHz) and locking of the repetition rate to an external reference is demonstrated with a phase error of 1.7 mrad (1 Hz–1 MHz). The simplicity of the laser makes it an attractive candidate as a module for integration into larger systems.
Status of the HIV epidemic in Manicaland, east Zimbabwe prior to the outbreak of the COVID-19 pandemic
Authors: Rao Adya , Moorhouse Louisa , Maswera Rufu , Dadirai Tawanda , Mandizvidza Phyllis , Nyamukapa Constance , Nayagam Shevanthi , Gregson Simon 
Published: September 2022

Background
Manicaland province in eastern Zimbabwe has a high incidence of HIV. Completion of the seventh round of the Manicaland Survey in 2018–2019 provided the opportunity to assess the state of the epidemic prior to the start of the COVID-19 pandemic. The study aims were to: a) estimate HIV seroprevalence and assess whether prevalence has declined since the last round of the survey (2012–2013), b) describe and analyse the socio-demographic and behavioural risk factors for HIV infection and c) describe the HIV treatment cascade.

Methods
Participants were administered individual questionnaires collecting data on socio-demographic characteristics, sexual relationships, HIV prevention methods and treatment access, and were tested for HIV. Descriptive analyses were followed by univariate and multivariate analyses of risk factors for HIV seropositvity using logistic regression modelling based on the proximate-determinants framework.

Results
HIV prevalence was 11.3% [95% CI; 10.6–12.0] and was higher in females than males up to 45–49 years. Since 2012–2013 HIV prevalence has significantly declined in 30–44 year-olds in males, and 20–44 year-olds in females. The HIV epidemic has aged since 2012–2013, with an increase in the mean age of HIV positive persons from 38 to 41 years. Socio-demographic determinants of HIV prevalence were church denomination in males, site-type, wealth-status, employment sector and alcohol use in females, and age and marital status in both sexes. Behavioural determinants associated with increased odds of HIV were a higher number of regular sexual partners (lifetime), non-regular sexual partners (lifetime) and condom use in both sexes, and early sexual debut and concomitant STIs in females; medical circumcision was protective in males. HIV status awareness among participants testing positive in our study was low at 66.2%. ART coverage amongst all participants testing positive for HIV in our study was 65.0% and was lower in urban areas than rural areas, particularly in males.

Conclusions
Prevalence has declined, and ART coverage increased, since 2012–2013. Majority of the associations with prevalence hypothesised by the theoretical framework were not observed in our data, likely due to underreporting of sexual risk behaviours or the treatment-as-prevention effect of ART curtailing the probability of transmission despite high levels of sexual risk behaviour. Further reductions in HIV incidence require strengthened primary prevention, HIV testing and linkage to risk behaviour counselling services. Our results serve as a valuable baseline against which to measure the impact of the COVID-19 pandemic on HIV prevalence and its determinants in Manicaland, Zimbabwe, and target interventions appropriately.
Evaluation of family planning service delivery in Gondar city public health facilities, Northwest Ethiopia: A cross-sectional study
Authors: Abay Sefiw , Hagos Tsega , Dellie Endalkachew , Yazachew Lake , Teshale Getachew , Debie Ayal 
Published: September 2022

Introduction
Family planning program is low-cost and an effective way to lower maternalmortality by reducing the number of high-risk births. Despite the effectiveness of the program, availability of materials, equipment and trained healthcare providers were some of the challenges in sub-Saharan African countries including Ethiopia. Determining the implementation status and identifying gaps is the aim of this evaluation.

Method
A facility-based cross-sectional evaluation design with mixed method approach was employed. Quantitative data was collected through the exit interview of 477 clients from March 25-April 25, 2020. The evaluation focused on three dimensions: availability, compliance, and acceptability with multiple data sources. The quantitative data were entered in to Epi-data version 4.6 and exported to SPSS version 25 for analysis. Multivariable logistic regression was done to determine factors associated with client satisfaction. The qualitative data were transcribed, translated and analyzed by using thematic analysis. The evaluation finding was computed and compared with the preset criteria for the final judgment.

Result
The majority of the health care providers (69.8%) got family planning training in the past two years. Three health facilities (37.5%) had 24hrs electricity with backup generators whereas only 25% of the health facilities had functional piped water inside the service room. Only two (25%) health facilities had a separate room for family planning service and 37.5% of health facilities had national FP guidelines. The overall availability of required resources for family planning service at Gondar city public facilities were 62.1%. Only twenty one (26.3%) of health providers dressed based on dressing code of ethics and none of them had ID during our observation. The overall compliance level of health care providers during providing family planning services were 75.5%. About 53.9% of the clients were satisfied with family planning service provided at Gondar city public health facilities.—and–were significantly associated variables with client satisfaction.

Conclusion
The overall implementation of family planning service in Gondar city public health facilities with the three evaluation dimensions were judged as fair based on pre-setting judgment matrix. It is better to improve the service through training of healthcare providers, distributed family planning guidelines to health facilities and shortening of waiting time for service.
Ethno-pharmacological investigations of Moringa stenopetala Bak. Cuf. and its production challenges in southern Ethiopia
Authors: Tesfaye Azene , Anjulo Agena , Fekadu Addisu , Beyene Kassaw , Girma Abebe , Gemeda Birhanu , Temesgen Gebremaryam , Wolde Fistum , Mulugeta Eyob , Manilal Aseer 
Published: September 2022

IntroductionMoringa stenopetalaBak. Cuf. is a native plant of Ethiopia with important nutraceutical applications. However, little is known about its nutritional, ethno-pharmaceutical and therapeutic properties. Hence, the present study sought to assess the nutraceutical applications ofM.stenopetalaamong traditional healers in southern Ethiopia.MethodsA community-based cross-sectional study was conducted on 50 selected administrative units in Gamo Gofa, Segen areas and south Omo zones of southern Ethiopia from May to June 2020. Data were gathered using a semi-structured interview, field observation, and group discussion. Both quantitative and qualitative data were analysed using Excel 2019 and open code version 4.03, respectively. The results were presented using descriptive statistics, with the fidelity level (FL)% used to distinguish the preferential use of various plant parts.ResultsA total of 120 individuals participated in the study, and the majority of them, 89 (74.2%), were male and farmers by occupation. Eight four (70%) of them were residents of the Gamo Gofa Zone. The fidelity level revealed that the leaf and root were the most commonly used parts for nutraceutical purposes. Remarkably,M.stenopetalais used to treat human ailments such as leprosy and kidney and liver infections via various modes of utilisation and administration. As a result, the most common methods of utilising plant products are chewing or consuming crushed plant parts, and the oral route is the much-preferred method of application. On the other hand, the larvae of Moringa mothNurda blitealis, are a defoliating insect during the rainy season and have been identified as a limiting factor for its production.ConclusionsThe nutraceutical aspects ofM.stenopetalaare extremely important to the rural community in southern Ethiopia. However, the defoliating moth larvae threaten its growth and biomass production, necessitating the need to manage and improve the plant’s productivity and sustainable use. Additionally, conducting experimental studies to validate the plant’s pharmacological potential correspond to a milestone in drug discovery.