bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual‐Modal Fluorescence‐SERS Detection of Blood Glucose Engineered by Hierarchical Laser‐Induced Micro/Nano Structures for Diabetes Screening
Authors: Lu Libin , Guan Shihe , Guan Yingchun , Hong Minghui 
Published: June 2022

AbstractSurface‐enhanced Raman spectroscopy (SERS) is a highly sensitive and selective vibrational spectroscopy, which has promising application in diabetes detection. However, the current detection methods usually suffer from poor reproducibility, time‐consumption, and complicated fabrication procedures, which limit their practical applications for large‐scale diabetes screening. Herein, a one‐step laser fabrication method to realize the integration of SERS and surface‐enhanced fluorescence (SEF) is introduced for rapid detection of glucose by generating controllable hierarchical laser‐induced periodic surface structures (LIPSS) on Si substrate. The proposed dual‐modal detection is to use SEF for first rapid qualitative analysis, and to apply SERS for later quantitative analysis of the glucose concentration. The SERS and SEF enhancement is up to 2.11 × 106 and 24.83, respectively, while the detection limit of SERS and SEF is × 10−9 and 1 × 10−6 mol L−1, respectively. Moreover, clinical verification of this dual‐modal detection of glucose in human blood samples is investigated, and the results are in good agreement with the clinical report. The present SERS‐SEF dual‐modal detection provides a facile and promising method for large‐scale diabetes screening.
Cover crop and nitrogen rate management practices influence corn NDVI and nitrogen content
Authors: Scott Drew A. , Johnson Jane M. F. , Gesch Russ W. 
Published: June 2022

AbstractCover crops are rarely adopted in the northern Corn Belt because of short growing periods but could provide benefits when grown between wheat (Triticum aestivum L.) and corn (Zea mays L.). We evaluated corn normalized difference vegetation index (NDVI) and leaf N (at six leaf, ear leaf, 75% silk, and physiological maturity), over three growing seasons in response to factorial treatments of cover crop of annual ryegrass [Lolium perenne L. ssp. multiflorum (Lam.) Husnot], radish [Raphanus sativus L.], and no‐cover control, and N rate (0×, 0.25×, 0.5×, and 1×) relative to the recommended rate based on pre‐plant soil tests (157–190 kg N ha−1). Grain N was also measured in the last study year (2016) to evaluate if leaf N indicated grain N. Radish cover crop increased corn NDVI relative to the no‐cover control, but annual ryegrass decreased NDVI relative to no‐cover control. This response to cover crop treatment suggests that radish cover crop may improve corn nutritional status. Corn receiving 1× N rate had the slowest decrease in leaf N over the growing season, but 2016 data revealed that grain from all treatments receiving some level of N had similar N content. Root biomass was also highest in the 0.5× N rate treatment and could explain the previously reported result that 0.5× N rate results in highest corn yield. Taken together, these results suggest that half the recommended N fertilizer can be used with little effect on nutritional status of corn following spring wheat in the northern Corn Belt.
Recent Advances in Copper‐Catalyzed Carboxylation Reactions with CO2
Authors: Song Yufei , Zhang Yu , Chen Zhengkai , Wu Xiao‐Feng 
Published: June 2022

AbstractAs an ideal one‐carbon synthon, CO2has been successfully utilized in diverse carboxylation reactions to construct a series of value‐added products. Among various transition‐metal catalysts, the inexpensive copper complexes exhibit unique catalytic activity in carboxylation reactions. This review summarizes the recent developments in copper‐catalyzed carboxylation reactions with CO2, the contents of which are divided into five parts based on the type of the substrates or products: organic halides and their surrogates, C−C double bonds, C−C triple bonds, C−H bonds and the synthesis of heterocycles.
Effect ofCaSt2/ESOthermal stabilizers on the preparation, thermal stability, and thermal stability mechanism of self‐made vinylidene chloride‐methyl acrylate copolymer resin film
Authors: Wang Lin , Yi Jie‐Min , Zhang Dong‐Qiao , Wang Meng , Peng Xiao‐Hong 
Published: June 2022

AbstractThe effects of heat stabilizer systems on the thermal stability and processability of self‐made vinylidene chloride‐methyl acrylate copolymer (PVDC‐MA) film were investigated via accelerated aging test, Congo red test, FTIR, DMA, and TG‐FTIR. These results displayed that CaSt2/ESO performed excellently in synergistic inhibition of PVDC‐MA thermal degradation. Especially, when the mass ratio of CaSt2/ESO was 1.5:1.5, the static thermal stability time of PVDC‐MA was increased from 14.5 to 46.5 min. The kinetic calculation results also verified this point. Compared with pure PVDC‐MA, the average apparent activation energy (Ēa) of thermal degradation reaction of PVDC‐MA stabilized by CaSt2/ESO enhanced from 144.1 to 169.7 kJ mol−1(α0 ≤ 0.1), indicating that the thermal stability of PVDC‐MA in the initial thermal degradation stage was dramatically improved by CaSt2/ESO. Moreover, the mechanism of the effect of CaSt2/ESO on PVDC‐MA in the initial thermal degradation stage was further explored by the generalized master plot methods. The kinetic analysis result suggested that under the synergistic effect of CaSt2/ESO, the mechanism model followed by the degradation of PVDC‐MA changed essentially (the three‐dimensional diffusion thermal degradation mechanism transformed into two‐dimensional diffusion).
Designed loose nanofiltration membrane for efficient separation of low molecular dye/salt
Authors: Jin Jinbo , Du Xilan , Yang Jingkui , Li Keda , Li Jian , Qin Shuhao , Yu Jie , He Min 
Published: June 2022

AbstractEfficient selective separation of low molecular weight dye/salt system is of great significance for promoting the development of membrane technology in the field of wastewater treatment. In this study, a loose nanofiltration membrane (LNF) was fabricated for the desalination of dye wastewater through a facile method. Firstly, styrene‐co‐maleic anhydride (SMA) containing anhydride group was added to PES membrane by blending, then polyethylene imide (PEI) was grafted onto the membrane surface by the reaction between amino group and anhydride group. Finally, the unreacted NH2 on the membrane surface were used for secondary cross‐linking with glutaraldehyde (GA) and ethylene glycol diglycidyl ether (EGDE) to obtain GA‐NF and EGDE‐NF membranes. Results showed that nanofiltration membranes with narrow pore size distribution and uniform structure are obtained. Compared with the aldehyde group in GA, the epoxy group in EGDE monomer has higher reactivity and hydrophilicity, which reacts with the amine group of PEI molecule to form hydrophilic hydroxyl group. Therefore, the water flux of EGDE‐NF membrane was about 20% higher than that of GA‐NF membrane, and the rejection of CR, AF, and EBT dyes was increased to more than 99%. Through chemical treatment of acid and alkali, both GA‐NF and EGDE‐NF membranes showed excellent separation performance stability.
Exploring hybrid vulcanization system in high‐molecular weight EPDM rubber composites: A statistical approach
Authors: Rahman Parathodika Arshad , Raju Aswathy Thuruthil , Das Mithun , Bhattacharya Asit Baran , Neethirajan Jeevanandham , Naskar Kinsuk 
Published: June 2022

AbstractElastomeric compound development is a multi‐objective optimization task, and it contains vulcanization packages that crosslink the matrix. The deciding factors for vulcanization systems are the nature of elastomer, service temperature, processing methods and vulcanizate properties. Accelerated sulfur and organic peroxide are examples of vulcanization systems; each has its advantages and shortcomings. The peroxide‐based system shows a high level of temperature stability while its flexibility is inferior to sulfur vulcanization. This study is fine‐tuning a hybrid vulcanization system containing a combination of ultra‐fast accelerated sulfur and a peroxide system; it also optimizes the vulcanization package ratios concerning various rheological and vulcanizate properties with the help of the Taguchi method. Ethylene propylene diene rubber (EPDM) is chosen as the basic matrix due to its excellent viability and commercial application with both the vulcanization systems. The formulations are optimized to combine the advantages of both the vulcanization systems. The results indicate that the vulcanization is sulfur‐driven, but peroxide influences by selecting the crosslink sites and type. The hybrid system uses more components, but proper optimization helps to reduce the quantity of vulcanization packages with an improvement in physio‐mechanical properties; it also helps to reduce the discharge of carcinogenic accelerator by‐products, such as nitrosamine.
Non‐Waste‐Wachsschalung für den individualisierten Betonfertigteilbau – Praxisbeispiel des digitalen Fertigungsprozesses für eine Kleinserie großformatiger Poller
Authors: Jonischkies Sven , Mainka Jeldrik , Kloft Harald , Kinzebach Wolfgang , Hack Norman 
Published: June 2022

AbstractAm Institut für Tragwerksentwurf, ITE, wurde in grundlegenden Forschungsarbeiten die Non‐Waste‐Wachsschalungstechnologie entwickelt, die in der Produktion von frei geformten Betonbauteilen Schalungsabfälle minimiert. Damit soll der Bedarf der Beton‐Fertigteilindustrie nach Technologien zur Reduktion der Produktionsabfälle und zum Aufbau emissionsarmer Produktionslinien erfüllt werden. Das aktuelle Eurostars‐geförderte Forschungsprojekt „Robocrete“ des ITE untersucht gemeinsam mit ODICO Construction Robotics, Odense, Dänemark, und BNB, Beton und Naturstein Babelsberg, Verfahren zur Herstellung von großformatigen Wachsblöcken für die industrielle Integration in Produktionslinien für Kleinserien. Ziel ist, die Forschungsergebnisse in einer digitalisierten robotischen Fertigungseinheit für Wachsschalungen für die Betonage zusammenzufassen. In vorangegangenen Forschungsprojekten war es bisher nicht möglich, riss‐ und spannungsfreie Wachsblockrohlinge mit einem Volumen von mehr als 1 m3 effizient herzustellen. Um dieses zu erreichen, werden derzeit optimierte Methoden zur Herstellung von Wachsblockrohlingen erforscht, die zudem in einem digitalen Fertigungsprozess formgebend bearbeitet werden. In einer Fallstudie unter Realbedingungen der Beton‐Fertigteilindustrie mit der Firma Rinn wurde die Wachsschalungstechnologie für den Betonguss eines geometrisch komplexen Pollers von über 1,2 t Gewicht erfolgreich getestet.
PDIA4, a novel ER stress chaperone, modulates adiponectin expression and inflammation in adipose tissue
Authors: Su Sheng‐Chiang , Chien Chu‐Yen , Chen Ying‐Chen , Chiang Chi‐Fu , Lin Fu‐Huang , Kuo Feng‐Chih , Huang Chia‐Luen , Li Peng‐Fei , Liu Jhih‐Syuan , Lu Chieh‐Hua , Ho Li‐Ju , Hsieh Chang‐Hsun , Hung Yi‐Jen , Shieh Yi‐Shing , Lee Chien‐Hsing 
Published: June 2022

AbstractIncreasing evidence supporting a causal link between obesity and endoplasmic reticulum (ER) stress in adipose tissue is being reported. Protein disulfide isomerase 4 (PDIA4) is a novel ER chaperone involved in the pancreatic β‐cells pathogenesis in diabetes. However, the role of PDIA4 in obesity progression remains poorly understood. To assess the relationship between PDIA4, adiponectin, and metformin, we used the palmitate‐induced inflammation in hypertrophic adipocytes and the high‐fat diet‐induced obesity mouse model. Our results revealed that palmitate‐induced hypertrophic adipocytes exhibit obesity‐associated conditions such as increased lipid accumulation, inflammation, and reduced glucose uptake. Pharmacological and genetic inhibition of PDIA4 significantly reverses these obesity‐associated conditions in adipocytes. PDIA4 mechanistically promotes obesity progression via adiponectin downregulation. Furthermore, metformin modulates PDIA4 and adiponectin expression and improves obesity‐associated conditions in both in vitro adipocytes and in vivo mouse models. Serum PDIA4 concentrations are also associated with body mass index, adiponectin, triglycerides, and inflammatory cytokines in humans. This is the first study demonstrating that PDIA4 modulates adipocytes by downregulating adiponectin. Moreover, metformin may serve as a potential therapeutic for preventing obesity via PDIA4‐targeting.
Autistic traits in trichotillomania
Authors: Grant Jon E. , Chamberlain Samuel R. 
Published: June 2022

AbstractIntroductionAlthough many variables have been examined as potentially contributing to the manifestation of trichotillomania (TTM), little research has focused on problems in social interactions. Hair pulling has many similarities to the stereotypies seen in autism spectrum disorders (ASD), and thus the present study examined autistic traits in adults with trichotillomania.MethodsFifty nontreatment‐seeking adults with DSM‐5 TTM were recruited. Participants completed standard diagnostic interviews, basic demographic information, and symptom inventories about TTM. Autistic traits were quantified using the Brief Autism‐ Spectrum Quotient (AQ‐10) which screens for autistic traits.ResultsThe sample comprised 50 participants, mean (standard deviation) age of 30.2 (5.6) years, 10% being male, 86% female, and 4% nonbinary. Eight of the participants had a history of major depressive disorder and six had a history of an anxiety disorder. No one had current or lifetime obsessive‐compulsive disorder. The mean AQ10 score was 3.5 (2.0), with 14.6% scoring 6 or greater. Autism scores correlated significantly only with family dysfunction and not with symptom severity or impulsivity.ConclusionsThis study examined autistic traits in a community‐based sample of adults with TTM and found elevated rates of probable ASD (based on a self‐report screening tool) among those with TTM. These results highlight the need to carefully screen for autistic traits in those with TTM. To what extent these traits may influence response to treatment, however, remains unclear.
Direct Growth of Carbon Nitride (C3N3) Nanosheets on Copper Foam as an Efficient Catalytic Electrode for Electrochemical Hydrogen Evolution
Authors: Wang Caifu , Zhang Zhonghai 
Published: June 2022

AbstractIn this work, carbon nitride (C3N3) nanosheets are directly synthesized on copper foam via a solvent‐free vapor‐solid phase reaction. Electrochemical measurement results indicate that C3N3 nanosheets achieve outstanding electrocatalytic performances with low overpotential (142 mV@10 mA cm−2) and small Tafel slope (75.5 mV dec−1), which are superior to most metal‐free hydrogen evolution reaction electrocatalysts in acid medium reported so far. In addition, the electrocatalytic performances of C3N3 nanosheets are further slightly improved under simulated solar irradiation. What's more, the synthetic strategy of C3N3 nanosheets could be extended to other substance system. More importantly, our impressive work was expected to inspire more potential researches in the future.
PROTOCOL: The association between marital transitions and physical and mental health in late life: A systematic review
Authors: Li Jing , Hui Xu , Lu Zhenxing , Ren Xiaocao , Yan Wenlong , Yan Peijing , Yao Liang , Yang Kehu 
Published: June 2022

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows: What is the association between marital transitions and physical health among people older than 60? What is the association between marital transitions and mental health among people older than 60? What is the role of gender, age, and education on the association between marital transitions and health among people older than 60? What is the influence of geographical region, housing, neighborhood, and social support on the association between marital transitions and health status among people older than 60?
Artificial intelligence processing electronic health records to identify commonalities and comorbidities cluster at Immuno Center Humanitas
Authors: Morandini Pierandrea , Laino Maria Elena , Paoletti Giovanni , Carlucci Alessandro , Tommasini Tobia , Angelotti Giovanni , Pepys Jack , Canonica Giorgio Walter , Heffler Enrico , Savevski Victor , Puggioni Francesca 
Published: June 2022

AbstractBackgroundComorbidities are common in chronic inflammatory conditions, requiring multidisciplinary treatment approach. Understanding the link between a single disease and its comorbidities is important for appropriate treatment and management. We evaluate the ability of an NLP‐based process for knowledge discovery to detect information about pathologies, patients' phenotype, doctors' prescriptions and commonalities in electronic medical records, by extracting information from free narrative text written by clinicians during medical visits, resulting in the extraction of valuable information and enriching real world evidence data from a multidisciplinary setting.MethodsWe collected clinical notes from the Allergy Department of Humanitas Research Hospital written in the last 3 years and used it to look for diseases that cluster together as comorbidities associated to the main pathology of our patients, and for the extent of prescription of systemic corticosteroids, thus evaluating the ability of NLP‐based tools for knowledge discovery to extract structured information from free text.ResultsWe found that the 3 most frequent comorbidities to appear in our clusters were asthma, rhinitis, and urticaria, and that 991 (of 2057) patients suffered from at least one of these comorbidities. The clusters which co‐occur particularly often are oral allergy syndrome and urticaria (131 patients), angioedema and urticaria (105 patients), rhinitis and asthma (227 patients). With regards to systemic corticosteroid prescription volume by our clinicians, we found it was lower when compared to the therapy the patients followed before coming to our attention, with the exception of two diseases: Chronic obstructive pulmonary disease and Angioedema.ConclusionsThis analysis seems to be valid and is confirmed by the data from the literature. This means that NLP tools could have significant role in many other research fields of medicine, as it may help identify other important, and possibly previously neglected clusters of patients with comorbidities and commonalities. Another potential benefit of this approach lies in its potential ability to foster a multidisciplinary approach, using the same drugs to treat pathologies normally treated by physicians in different branches of medicine, thus saving resources and improving the pharmacological management of patients.
Hemophagocytosis on ascitic fluid cytology: Diagnosis of HLH
Authors: Abou Shaar Rand , Perry Kyle D. , Otrock Zaher K. 
Published: June 2022

AbstractHemophagocytic lymphohistiocytosis (HLH) is a life‐threatening syndrome of pathologic immune response characterized by excessive activation of macrophages. Hemophagocytosis is one of the diagnostic criteria for HLH, and it usually involves the bone marrow, spleen, lymph nodes, or any part of the reticuloendothelial system. Hemophagocytosis in the ascitic fluid has rarely been reported in HLH. Here, we report the case of a patient who presented with fever and abdominal distention and ascites. Ascitic fluid cytology showed hemophagocytosis which was the clue for HLH diagnosis. We also review the literature for this rare cytological occurrence.
Computational thermodynamics‐assisted design of nitrate‐based phase change materials for waste heat recovery
Authors: Huang Wan‐Yu , Liu Yu‐chen , Lin Shih‐kang , Chen Wei‐Hsin 
Published: June 2022

SummaryPhase change materials (PCMs) are substances that absorb or release latent heat during changes in physical state. PCM is typically introduced in a heat exchanger inside a waste heat recovery system to enhance energy conversion efficiency. Molten salts consisting of multiple components are widely used as a PCM due to their high heat capacity. However, modulating the physical properties of PCMs via experimental trial‐and‐error is not economically feasible when dealing with complex systems. In this study, we designed six potential nitrates as PCMs via a combinatorial approach with the CALculation of PHAse Diagrams (CALPHAD) method, the Kissinger model, and experimental validations, among the KNO3‐NaNO3‐LiNO3 ternary system. The measured thermodynamics properties, including the solidus and liquidus temperatures, and enthalpy changes, were in agreement with the predicted values. A promising PCM that exhibited a lower melting activation energy (917.3 kJ/mol) and a higher change in enthalpy (136.4 J/g) than those of the commercial HITEC salt (1135.3 kJ/mol and 86 J/g). The designed PCM also showed a good thermal stability with the 316 stainless steel, which is a typical container material, at temperatures of 150°C and 300°C, respectively, for up to 1 month. The designed PCM is considered promising for waste heat recovery applications in terms of its high heat storage capacity, high heat exchange efficiency, and high thermal stability.
Design and characterization of a chimeric alginate lyase for immobilization to produce well‐defined oligosaccharides
Authors: Zhang Hongxiu , Lyu Qianqian , Liu Xiaohua , Liu Weizhi 
Published: June 2022

AbstractRecently, a novel two‐domain alginate lyase (AlyAL01) was cloned from Algibacter sp. and successfully overexpressed in Escherichia coli BL21(DE3). Biochemical analysis showed that the N‐terminal carbohydrate‐binding module (CBM) of AlyAL01 had no effect on the enzyme activity and product distributions. Therefore, the N‐terminal CBM was substituted with CBM3 to confer the designed chimeric protein with the ability to specifically bind to regenerated amorphous cellulose. As anticipated, the designed chimeric protein (CBM3‐L1) exhibited a similar enzyme activity. Moreover, it was found that the CBM3‐L1 combined the purification and immobilization in one step with high immobilized efficiency of 65.8%. The immobilized enzyme exhibited good storage stability and moderate reusability. The immobilized enzyme could keep 85% activity when incubated at 4°C for 60 days and 70% activity when incubated at 25°C for 30 days. Furthermore, the immobilized CBM3‐L1 kept about 50% of its initial activity after being reused five times. Finally, immobilized CBM3‐L1 successively produced well‐defined alginate oligosaccharides (AOS) with DPs of 2–6 by controlling reaction time. In sum, our current study provided a feasible strategy for well‐defined AOS production.
Supporting distributed and integrated execution of future‐oriented technology analysis
Authors: Barbosa Carlos E. , Lima Yuri , Emerick Matheus , Ferman Fabio , Ribeiro Fernanda C. , Moreira de Souza Jano 
Published: June 2022

AbstractLarge organizations usually spread their research and development (R&D) around the world, hindering coordination efforts when performing future‐oriented technology analysis (FTA) studies. FTA is commonly used in R&D planning, especially on research prioritization. Therefore, we developed an FTA framework for large and geographically spread organizations, named Tiamat. The Tiamat framework is composed of a simplified organization model, which focuses on internal and external interactions during FTA, and an FTA process, which indicates the steps performed by the decision‐maker need until the delivery of the FTA final report from the organization. Based on the Tiamat framework, we developed the Tiamat software, a modular tool that implements generic FTA using the concept of workflows of FTA methods. Thus, we describe the architecture and collaboration aspects of the Tiamat software. The Tiamat framework (i.e., model and process) and the Tiamat software were applied in real situations to evaluate its FTA support capability. Besides, we show non‐FTA uses of the Tiamat software to showcase its flexibility. Among the contributions, we highlight the use of the Tiamat framework in the management of a standardized FTA process, based on the concept of workflows. The framework was developed to be easily adapted to many types of organizations, such as businesses, universities, and public institutions, either civil or military. The Tiamat software has shown to be capable to support distributed and local FTA studies, as well non‐FTA studies.