bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KEPEMIMPINAN DAN DISIPLIN KERJA TERHADAP KINERJA APARATUR SIPIL NEGARA PADA DINAS PEMUDA, OLAHRAGA, DAN PARIWISATA KABUPATEN PASAMAN
Authors: Yurasti Yurasti , Putri Rahmi Faura 
Published: October 2022

This research were done, in order to determined the effect of ledearship and work discipline on the job performance of civil servants on regional office of Youth, Sports and Tourism of Pasaman Regency. The sample in this study amounted to 51 respondents. The data collected in this study were analyzed using multiple linear regression. The results showed that partially leadership had a significant effect on the job performance of civil servants on Regional Office of Youth, Sports and Tourism of Pasaman Regency, with a significant value of 0.000 < alpha 0.05. Work discipline partially has no significant effect on the job performance of civil servants on Regional Office of Youth, Sports and Tourism Office of Pasaman Regency with a significant value 0.615 > alpha 0.05. Simultaneously leadership and work discipline have a significant effect on the job performance of state civil aparatus at Regional Office of Youth, Sports and tourism of Pasaman Regency, with a significant value 0.000 < alpha 0.05. The results of the coefficient of determination test indicated that leadership and work discipline contribute 51% of job performance of civil servants Keyword: Leadership, Work Discipline, and Job Performance
A comparative study of PSPVP and PSIBG in the treatment of stage II–III Kummell’s disease
Authors: Zhang Jian-Qiao , Zeng Zhong-You , Lu Hui-Gen , Yu Wei , Hu Xu-Qi , Chen Wei-Shan , Chen Gang 
Published: October 2022

BACKGROUND: Percutaneous kyphoplasty (PKP) or percutaneous vertebroplasty (PVP) are commonly employed for Kummell’s disease in stages II–III; however, these techniques produce some complications. OBJECTIVE: To compare the clinical efficacy and imaging results of percutaneous vertebroplasty + bone cement-augmented short-segment pedicle screw fixation (PSPVP) versus transpedicular intracorporeal bone grafting + pedicle screw fixation (PSIBG) in the treatment of stage II–III Kummell’s disease. METHODS: A total of 69 patients admitted between November 2017 and March 2021 were included in this study; 36 of these were treated with PSPVP, and 33 were treated with PSIBG. Patients in the two groups were compared in terms of perioperative, follow-up, and imaging data. RESULTS: No statistically significant differences were found between the two groups in terms of operation duration (P > 0.05). However, the PSPVP group was superior to the PSIBG group in terms of incision length, intraoperative blood loss, and length of stay (P < 0.05). All patients were followed up for more than 12 months. The VAS score, height of anterior vertebral margin, kyphosis Cobb angle, wedge angle of the affected vertebra at seven days after surgery and last follow-up, and the ODI index at the last follow-up of the two groups were significantly improved compared with figures before surgery (P < 0.05). Compared with values before surgery, no statistically significant differences were found in the height of the posterior vertebral margin in the PSPVP group at seven days after surgery and at the last follow-up (P > 0.05). There were also no statistically significant differences in the VAS score, ODI index, kyphosis Cobb angle, and wedge angle of the affected vertebra between the two groups at corresponding time points (P > 0.05). The heights of the anterior and posterior vertebral margins in the PSIBG group were better than those in the PSPVP group after surgery and at the last follow-up (P < 0.05). In the PSPVP group, a pedicle screw fracture occurred in one patient two months after surgery, while an upper adjacent vertebral fracture occurred in one patient eight months after surgery. CONCLUSION: Both PSPVP and PSIBG can achieve good early clinical efficacy in the treatment of stage II–III Kummell’s disease, with PSPVP being relatively less invasive while producing a poorer orthopedic effect and more complications than PSIBG.
FORMULASI SEDIAAN GEL HAND SANITIZER DARI EKSTRAK ETANOL DAUN BELIMBING WULUH (AVERHOA BLIMBI L.) KOMBINASI GEL LIDAH BUAYA (ALOE VERA)
Authors: Zarwinda Irma , Elfariyanti Elfariyanti , Adriani Azmalina , Agustina Mutia 
Published: October 2022

Hand sanitizer gel merupakan pembersih tangan berbentuk gel yang berguna untuk membersihkan atau menghilangkan kuman pada tangan. Hand sanitizer dapat dibuat dari daun belimbing wuluh (Averrhoa bilimbi L.) kombinasi daun lidah buaya (Aloe vera) karena mengandung senyawa antibakteri. Penelitian ini bertujuan untuk membuat formulasi hand sanitizer ekstrak etanol daun belimbing wuluh kombinasi gel lidah buaya dengan variasi konsentrasi F0(0%), F1(1%), F2(2%), dan F3(3%) serta mengetahui mutu fisiknya. Sampel yang digunakan adalah 4 sediaan formulasi gel hand sanitizer ekstrak etanol daun belimbing wuluh kombinasi gel lidah buaya yaitu F0, F1, F2, dan F3. Pengujian dilakukan pada hari ke 1, 7 dan 14. Hasil pemeriksaan mutu fisik hand sanitizer pada keempat sediaan adalah homogen, warna yang dihasilkan tetap stabil, berbentuk gel dan berbau khas ekstrak daun belimbing wuluh. Hasil uji pH semua sedian memenuhi syarat yaitu 4-10. Semua sedian juga memenuhi syarat viskositas gel. Hasil uji iritasi sedian untuk F0, F1, dan F3 tidak menyebabkan iritasi namun sediaan F2 menyebabkan iritasi salah satu sukarelawan. Hasil uji daya sebar semua sedian juga memenuhi syarat yaitu yaitu 5-7. Dapat disimpulkan bahwa formulasi hand sanitizer ekstrak etanol daun belimbing wuluh kombinasi daun lidah buaya dengan variasi konsentrasi F0(0%), F1(1%), F2(2%), dan F3(3%) memiliki mutu fisik yang baik.
Kajian Industri Energi Terbarukan Tenaga Listrik di Indonesia Berdasarkan Arah Kebijakan dan Potensi Alam
Authors: Hertadi Christopher Davito Prabandewa , Sulaiman Mochamad , Anwar Putri Gesan Prabawa 
Published: October 2022

Indonesia berkomitmen untuk mencapai target Net Zero Emission pada tahun 2060. Target tersebut dapat dicapai dengan melihat potensi penerapan energi terbarukan yang ada di Indonesia. Ketergantungan Indonesia dalam pembangkitan tenaga listrik menggunakan bahan bakar fosil masih besar. Penelitian ini dimaksudkan untuk melihat potensi yang bisa dilakukan baik pemerintah Indonesia dalam membuat kebijakan maupun masyarakat dalam menyukseskan komitmen Net Zero Emission. Hasil penelitian menunjukkan bahwa potensi penerapan Pembangkit Listrik Tenaga Surya (PLTS) di Indonesia masih sangat besar dengan pemanfaatan 92% konsumen PLN yaitu konsumen rumah tangga. Namun penelitian ini baru sebatas penelitian awal.
SYNTHESIS OF COMPLEX OXIDES OF COBALT-NEODYMIUM FROM HETEROCOMPLEXES AND THEIR CATALYTIC ACTIVITY IN THE DE­COM­POSITION OF HYDROGEN PEROXIDE
Authors: Sliusarchuk Liudmyla , Zheleznova Lidia , Kuleshov Serhii , Rohovtsov Oleksandr , Trunova Olena , Khomenko Borys 
Published: October 2022

New heterometallic complexes of Сo(II) and Nd(III) with carboxylic acids (succinic, oxalic) and acetylacetone in the presence of phenanthroline or α,α'-dipyridyl have been synthesized. Their thermal properties and the ability to form complex oxides during thermal degradation have been studied. In the process of thermolysis of heterocomplexes, neodymium cobaltate NdCoO3 was obtained, which is confirmed by the results of X-ray powder diffraction.
The research has established that the X-ray powder diffraction patterns of the products obtained by thermolysis of heterocomplex [Сo2Nd2(C4Н4O4)5·2Phen]·4Н2О to 1000 °С exhibits peaks at (2θ): 23.40, 33.74, 41.42, 48.32, 54.52, 59.94, 70.58°. This corresponds to the neodymium cobaltate NdCoO3. Neodymium cobaltate crystallizes in the cubic crystal system. The sample was obtained without extraneous phases inclusions. For the samples obtained by the termolysis of he­te­rocomplexes [Сo2Nd2(C2O4)5·2Phen]·4Н2О and NdCo(AA)5·2α,α'-dipy, in addition to the complex oxide NdCoO3, peaks of Nd2O3 were recorded, which crystallizes in the hexa­gonal crystal system. The X-ray powder diffraction patterns show peaks with 2θ values: 26.92, 29.75, 30.77, 40.54, 47.53, 53.63, 57.08°. The phase ratio of NdCoO3/Nd2O3 after termolysis for the sample of CoNd(AA)5·2α,α'-dipy is ~ 68.9/31.1%; for the sample of [Сo2Nd2(C2O4)5·2Phen]·4Н2О is ~ 50/50%; for the sample of [Сo2Nd2(C4Н4O4)5·2Phen]·4Н2О is NdCoO3 ~ 100%. The average crystallites size of complex oxides was calculated using the Scherer formula. It has been showed that neodymium cobaltate has an average particle size of ~33 nm, regardless of the complex precursor from which it was formed during thermolysis.
The catalytic effect of neodymium cobaltates in the hydrogen peroxide decomposition reaction was studied. It was shown that all samples of complex oxides showed a quite high cataly­tic activity in the all of experiments in the hydro­gen peroxide decomposition reactions.
PENDAMPINGAN TEKNIS MUTU HIGIENIS, KEMASAN, DAN OTOMASI PENGOLAHAN PRODUK USAHA MIKRO SATE MANIS BALUT KACANG MERGOSONO MALANG MENUJU GO NUSANTARA
Authors: Moentamaria Dwina , Puspitasari Ayu , Widjanarko  
Published: October 2022

Pandemi Covid-19 memberikan hikmah keseriusan, tantangan yang luar biasa pada semua sektor kehidupan, agar semua berjalan seperti biasa. Penyediaan kebutuhan pangan menjadi penting, seiring dengan protokol kesehatan yang ketat untuk selalu hidup bersih dan menjaga jarak. Hal ini belum pernah dipikirkan sebelumnya, terutama dalam jangkauan industri kecil tentang pemesanan olahan pangan sistem on line jarak jauh, take way untuk rumah makan-kafe. Industri Rumah Tangga (IRT), UKM, mempresepsikan masa pandemi ini sebagai tantangan untuk memperbaiki kualitas produksinya agar lebih diterima masyarakat yang saat ini lebih selektif memilih makanan sehat, tanpa resiko penularan penyakit yang disebabkan oleh bakteri, jamur, virus. IRT berlabel sate manis balut kacang SIDOSEMI menerapkan produk pangan sehat , aman tanpa pengawet dan bahan tambahan pangan lainnya Produk sate manis dalam kemasan telah diproduksi rata-rata 400 tusuk/hari, dengan kualitas empuk, rasa eksotik rempah nusantara yang melegenda. Upaya yang telah dilakukan IRT SIDOSEMI dengan mengikuti berbagai pelatihan olahan pangan , masih belum mampu diimplementasikan untuk menjadi produk yang unggul. Permasalahan yang dihadapi oleh IRT adalah produk sate manis tidak dapat bertahan lebih dari 24 jam pendistribusian. Kemasan sate yang digunakan adalah plastik yang telah divakum, saat pengiriman diberi es dimasukkan ke styroform. Hasil penelitian di laboratorium Teknik Kimia Politeknik Negeri Malang (POLINEMA) , ditemukan timbulnya jamur, setelah sate manis dibiarkan pada suhu kamar, selama waktu 2 x 24 jam. Hal ini menyebabkan jangkauan distribusinya terbatas hanya di sekitar Malang Raya. Proses produksi, terdiri penggilingan bahan baku daging, bumbu rempah, kacang; pencetakan; pembakaran; pengemasan. Ada 5 (lima) permasalahan dalam pengelolaan IRT SIDOSEMI yaitu i) proses produksi masih manual, kemasan plastik tidak kedap udara-cahaya, ii) manajemen pemasaran on line masih standart, iii) aspek kewirausahaan, belum adanya inovasi produk yang daya bersaing ,iv)administrasi keuangan masih sederhana,v) manajemen mutu dan kesehatan masih rendah, belum memperhatikan aspek standart mutu dan higienitas produk. Aspek permasalahan produksi, kemasan, mutu dan kesehatan menjadi titik kritis karena berhubungan potensi besar kontaminasi, karena dilakukan secara manual dengan waktu lama tanpa kendali standart mutu. Sedang permasalahan lainnya sebagai pendukung perlu dioptimalisasi. Solusi yang ditawarkan melalui Program Kemitraan Masyarakat (PKM), diharapkan dapat membantu menyelesaikan masalah pendeknya waktu distribusi ke konsumen dengan memutus kontaminasi akibat mata rantai jamur,bakteri patogen sehingga produk olahan ini menjadi lebih awet.
The potential of conservation agriculture to improve nitrogen fixation in cowpea under the semi-arid conditions of Kenya
Authors: Binacchi Ferdinando , Rusinamhodzi Leonard , Cadisch Georg 
Published: October 2022

Low-cost but productive crop intensification options are needed to assist smallholder farmers in the tropics to move away from poverty. This study assessed the capacity of cowpea (Vigna unguiculata (L.) Walp.) to perform biological N fixation (BNF) under no-tillage practices, crop residue cover and intercropping with maize (Zea mays L.). The study was performed during the long rains of 2017 at Kiboko experimental station, located in semi-arid eastern Kenya. The research field trials had been running for three years (6 cropping seasons) by the time the sampling took place. The experimental set up was a split-plot design: main plots being tillage system (no till + maize stover retention (CA), and conventional tillage to 15 cm depth without mulch retention (CT)), sub-plot being cropping system (maize-cowpea intercrop, maize monocrop, and cowpea monocrop). Cowpea plants were sampled at 50% flowering stage and at physiological maturity to investigate biomass production and %N derived from the atmosphere (%Ndfa) through the 15N natural abundance technique, using maize as a reference control. Results showed that the number of nodules per plant was higher in CA treatments rather than in CT although not significant (p&gt;0.05). Mean cowpea grain yield at harvest varied between 472 – 590 kg ha‐1 in intercrops whereas grain yield in monocrops was between 1465 - 1618 kg ha-1. Significant differences were however recorded between treatments with CT monocropped cowpea at flowering recording the highest mean %Ndfa (62%) and CT intercrop the lowest (52%). At harvest stage CA inter recorded the highest %Ndfa (54%) while CT intercrop the lowest (41%). The %Ndfa was higher (p&lt;0.05) at flowering (between 57- 69%) compared with 45 - 64 % at harvest stage. Overall cowpeas in intercrops derived between 17.8 - 22.8 kg ha-1 of their total N from atmospheric dinitrogen fixation while monocrops between 54.9 - 55.2 kg ha-1. The effect of CA on BNF was positive but not significantly different from CT. These results suggest that CA has the potential to enhance the BNF process but there is a need to explore in future alternative spatial arrangement and variety choice in intercropping of cowpea and maize to optimize the BNF process.
Rapid and sensitive detection of tenuazonic acid in agricultural by-products based on gold nano-flower lateral flow
Authors: Cai Peiyuan , Wang Rongzhi , Ling Sumei , Wang Shihua 
Published: October 2022

Tenuazonic acid (TA) is a highly toxic mycotoxin mainly generated by the fungi of Alternaria genus and widely contaminates agricultural by-products. Given the threat of TA to food-security, it is very important to develop rapid and sensitive detection methods for TA monitoring. In this study, gold nano-particles (AuNP) with average diameter near 17.25 nm were prepared, and the developed AuNP-based strip has an assay time of 15 min with visual limit of detection (LOD) of 12.5 ng/ml and threshold of 100 ng/ml. To further improve sensitivity, multi-branched gold nano-flowers (AuNF) with average diameter near 50 nm were prepared and characterized by UV-VIS and TEM, and the established AuNF-based strip has visual LOD of 0.78 ng/ml and threshold of 50 ng/ml within 15 min. Both assays were applied to determine TA in apple juice and tomato ketchup, and the results were consistent with that of UHPLC-MS/MS. Thus, these assays could be applied for rapid determination of trace TA in real samples.
Assessing heat index changes in the context of climate change: A case study of Hanoi (Vietnam)
Authors: Hoang Thuy L. T. , Dao Hung N. , Cu Phuong T. , Tran Van T. T. , Tong Tuan P. , Hoang Son T. , Vuong Vu V. , Nguyen Thang N. 
Published: October 2022

Air temperature and humidity have a great impact on public health, leads to heat stress. The US National Weather Service uses temperature and relative humidity to build a heat index (HI) as a metric to identify the thresholds for heat stress as felt by the public. Under climate change conditions and especially in hot humid weather during summer, the number of hot days in Hanoi has increased in recent times. Subsequently, the heat index is rising in both number of occurrences and level of intensity leading to increasing temperature stress on people’s health. The daily heat index for the future was simulated using maximum daily temperature and minimum daily relative humidity based on climate change scenarios. Maximum daily temperature was provided by the climate change model, while minimum daily relative humidity was estimated from the following: maximum daily temperature, mean daily temperature and daily rainfall. Results show that in the future, the heat index will increase by 0.0777°C/year in the RCP 4.5 scenario and 0.08°C/year in the RCP 8.5 scenario. Number of weeks with heat at danger tends to increase to 5.5 weeks/5 year for scenario RCP 4.5, and it is 6 weeks/5 years under RCP 8.5 scenario. In particular, the number of days of heatstroke over a 30-year period (from 1991 to 2020) amounted to only 4, that is an average of 0.13 days of the year, which represents a very rare weather phenomenon in the past. In contrast, under an RCP 4.5 scenario in the future over a 30-year period, the average number of days per year will be 2, 57 days; while the average number of days per year under an RCP 8.5 scenario would be 3, 87 days. This phenomenon will be mainly concentrated in the months of June, July, and August. Projections of this type are a key tool for communities working out how they will adapt to heat stress in the context of climate change.
Higher plasma aldosterone is associated with increased risk of cardiovascular events in hypertensive patients with suspected OSA: UROSAH data
Authors: Gan Lin , Li Nanfang , Heizhati Mulalibieke , Lin Mengyue , Zhu Qing , Yao Xiaoguang , Wu Ting , Wang Menghui , Luo Qin , Zhang Delian , Jiang Wen , Hu Junli 
Published: October 2022

ObjectiveTo evaluate the association of plasma aldosterone concentration (PAC) with incident cardiovascular disease (CVD) and all-cause mortality in hypertensive patients with suspected obstructive sleep apnea (OSA) and calculate the optimal cut-off value of PAC for this specific population.Patients and methodsParticipants with PAC at baseline in UROSAH in 2011-2013 were enrolled and followed up till 2021. Composite outcome included CVD and all-cause mortality. Cox proportional hazards model was used to evaluate the relationship between PAC and the composite outcome. Time-dependent ROC curve was used to determine the optimal cut-off value of PAC. Besides, we conducted subgroup analyses and sensitivity analyses.Results3173 hypertensive participants aged 18-84 years comprised analytical sample. During a median follow-up of 7.3 years and 22640 person-years, 69 deaths and 343 cases of incident CVD occurred. The incidence of composite outcome was increased with elevation in tertile of PAC. Compared with the first tertile, the risk of CVD and all-cause death was higher in third tertile (HR=1.81, 95%CI: 1.39-2.35, P&lt;0.001). Time-dependent ROC curve showed optimal threshold for PAC was 12.5ng/dl. Whether renin was suppressed or not (≤0.5 or &gt;0.5ng/ml per h), elevated PAC was associated with an increased risk of CVD. Our results remained stable and consistent in sensitivity analyses.ConclusionHigher PAC was associated with increased risk of CVD and all-cause mortality in hypertensives with suspected OSA, even in the absence of primary aldosteronism (PA). Hypertensives with PAC≥12.5ng/dl showed a significantly increased risk of CVD, indicating that special attention and treatment were required in this specific population.
Evaluation of ketoconazole as a treatment for Cushing’s disease in a retrospective cohort
Authors: Viecceli Camila , Mattos Ana Carolina Viana , Costa Maria Carolina Bittencourt , Melo Rafael Borba de , Rodrigues Ticiana da Costa , Czepielewski Mauro Antonio 
Published: October 2022

ObjectiveThe first-line treatment for Cushing’s disease is transsphenoidal surgery, after which the rates of remission are 60 to 80%, with long-term recurrence of 20 to 30%, even in those with real initial remission. Drug therapies are indicated for patients without initial remission or with surgical contraindications or recurrence, and ketoconazole is one of the main available therapies. The objective of this study was to evaluate the safety profile of and the treatment response to ketoconazole in Cushing’s disease patients followed up at the endocrinology outpatient clinic of a Brazilian university hospital.Patients and methodsThis was a retrospective cohort of Cushing’s disease patients with active hypercortisolism who used ketoconazole at any stage of follow-up. Patients who were followed up for less than 7 days, who did not adhere to treatment, or who were lost to follow-up were excluded.ResultsOf the 172 Cushing’s disease patients who were followed up between 2004 and 2020, 38 received ketoconazole. However, complete data was only available for 33 of these patients. Of these, 26 (78%) underwent transsphenoidal surgery prior to using ketoconazole, five of whom (15%) had also undergone radiotherapy; seven used ketoconazole as a primary treatment. Ketoconazole use ranged from 14 days to 14.5 years. A total of 22 patients had a complete response (66%), three patients had a partial response (9%), and eight patients had no response to treatment (24%), including those who underwent radiotherapy while using ketoconazole. Patients whose hypercortisolism was controlled or partially controlled with ketoconazole had lower baseline 24-h urinary free cortisol levels than the uncontrolled group [times above the upper limit of normal: 0.62 (SD, 0.41) vs. 5.3 (SD, 8.21); p &lt; 0.005, respectively] in addition to more frequent previous transsphenoidal surgery (p &lt; 0.04). The prevalence of uncontrolled patients remained stable over time (approximately 30%) despite ketoconazole dose adjustments or association with other drugs, which had no significant effect. One patient received adjuvant cabergoline from the beginning of the follow-up, and it was prescribed to nine others due to clinical non-response to ketoconazole alone. Ten patients (30%) reported mild adverse effects, such as nausea, vomiting, dizziness, and loss of appetite. Only four patients had serious adverse effects that warranted discontinuation. There were 20 confirmed episodes of hypokalemia among 10/33 patients (30%).ConclusionKetoconazole effectively controlled hypercortisolism in 66% of Cushing’s disease patients, being a relatively safe drug for those without remission after transsphenoidal surgery or whose symptoms must be controlled until a new definitive therapy is carried out. Hypokalemia is a frequent metabolic effect not yet described in other series, which should be monitored during treatment.