bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Epigenomic Alterations in HPV16+ Head and Neck Squamous Cell Carcinomas
Authors: Berglund Anders , Muenyi Clarisse , Siegel Erin M. , Ajidahun Abidemi , Eschrich Steven A. , Wong Denise , Hendrick Leah E. , Putney Ryan M. , Kim Sungjune , Hayes D. Neil , Shibata David 
Published: January 2022

Abstract

Background:
Epigenetic changes associated with human papillomavirus (HPV)–driven tumors have been described; however, HPV type–specific alterations are less well understood. We sought to compare HPV16-specific methylation changes with those in virus-unassociated head and neck squamous cell carcinomas (HNSCC).

Methods:
Within The Cancer Genome Atlas, 59 HPV16+ HNSCC, 238 nonviral HNSCC (no detectable HPV or other viruses), and 50 normal head and neck tissues were evaluated. Significant differentially methylated regions (DMR) were selected, and key associated genes were identified. Partial least squares models were generated to predict HPV16 status in additional independent samples.

Results:
HPV infection in HNSCC is associated with type-specific methylomic profiles. Multiple significant DMRs were identified between HPV16+, nonviral, and normal samples. The most significant differentially methylated genes, SYCP2, MSX2, HLTF, PITX2, and GRAMD4, demonstrated HPV16-associated methylation patterns with corresponding alterations in gene expression. Phylogenetically related HPV types (alpha-9 species; HPV31, HPV33, and HPV35) demonstrated a similar methylation profile to that of HPV16 but differed from those seen in other types, such as HPV18 and 45 (alpha-7).

Conclusions:
HNSCC linked to HPV16 and types from the same alpha species are associated with a distinct methylation profile. This HPV16-associated methylation pattern is also detected in cervical cancer and testicular germ cell tumors. We present insights into both shared and unique methylation alterations associated with HPV16+ tumors and may have implications for understanding the clinical behavior of HPV-associated HNSCC.

Impact:
HPV type–specific methylomic changes may contribute to understanding biologic mechanisms underlying differences in clinical behavior among different HPV+ and HPV− HNSCC.
Reproductive Factors Do Not Influence Survival with Ovarian Cancer
Authors: Phung Minh Tung , Alimujiang Aliya , Berchuck Andrew , Anton-Culver Hoda , Schildkraut Joellen M. , Bandera Elisa V. , Chang-Claude Jenny , Chase Anne , Doherty Jennifer Anne , Grout Bronwyn , Goodman Marc T. , Hanley Gillian E. , Lee Alice W. , McKinnon Deurloo Cindy , Menon Usha , Modugno Francesmary , Pharoah Paul D.P. , Pike Malcolm C. , Richardson Jean , Risch Harvey A. , Sieh Weiva , Terry Kathryn L. , Webb Penelope M. , Wentzensen Nicolas , Wu Anna H. , Pearce Celeste Leigh 
Published: January 2022

Abstract

Background:
Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes.

Methods:
Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian tube, or primary peritoneal cancer (ovarian cancer) from 16 studies in the Ovarian Cancer Association Consortium (OCAC), we examined the associations between survival and age at menarche, combined oral contraceptive use, parity, breastfeeding, age at last pregnancy, and menopausal status using Cox proportional hazard models. The models were adjusted for age at diagnosis, race/ethnicity, education level, and OCAC study and stratified on stage and histotype.

Results:
During the mean follow-up of 6.34 years (SD = 4.80), 6,418 patients passed away (57.4%). There was no evidence of associations between the reproductive factors and survival among patients with ovarian cancer overall or by histotype.

Conclusions:
This study found no association between reproductive factors and survival after an ovarian cancer diagnosis.

Impact:
Reproductive factors are well-established risk factors for ovarian cancer, but they are not associated with survival after a diagnosis of ovarian cancer.
Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer Exhibits Antitumor Efficacy with Low Toxicity
Authors: Tully Kathryn M. , Tendler Salomon , Carter Lukas M. , Sharma Sai Kiran , Samuels Zachary V. , Mandleywala Komal , Korsen Joshua A. , Delos Reyes Avelyn Mae , Piersigilli Alessandra , Travis William D. , Sen Triparna , Pillarsetty Nagavarakishore , Poirier John T. , Rudin Charles M. , Lewis Jason S. 
Published: January 2022

AbstractPurpose:Small cell lung cancer (SCLC) is an exceptionally lethal form of lung cancer with limited treatment options. Delta-like ligand 3 (DLL3) is an attractive therapeutic target as surface expression is almost exclusive to tumor cells.Experimental Design:We radiolabeled the anti-DLL3 mAb SC16 with the therapeutic radioisotope, Lutetium-177. [177Lu]Lu-DTPA-CHX-A”-SC16 binds to DLL3 on SCLC cells and delivers targeted radiotherapy while minimizing radiation to healthy tissue.Results:[177Lu]Lu-DTPA-CHX-A”-SC16 demonstrated high tumor uptake with DLL3-target specificity in tumor xenografts. Dosimetry analyses of biodistribution studies suggested that the blood and liver were most at risk for toxicity from treatment with high doses of [177Lu]Lu-DTPA-CHX-A”-SC16. In the radioresistant NCI-H82 model, survival studies showed that 500 μCi and 750 μCi doses of [177Lu]Lu-DTPA-CHX-A”-SC16 led to prolonged survival over controls, and 3 of the 8 mice that received high doses of [177Lu]Lu-DTPA-CHX-A”-SC16 had pathologically confirmed complete responses (CR). In the patient-derived xenograft model Lu149, all doses of [177Lu]Lu-DTPA-CHX-A”-SC16 markedly prolonged survival. At the 250 μCi and 500 μCi doses, 5 of 10 and 7 of 9 mice demonstrated pathologically confirmed CRs, respectively. Four of 10 mice that received 750 μCi of [177Lu]Lu-DTPA-CHX-A”-SC16 demonstrated petechiae severe enough to warrant euthanasia, but the remaining 6 mice demonstrated pathologically confirmed CRs. IHC on residual tissues from partial responses confirmed retained DLL3 expression. Hematologic toxicity was dose-dependent and transient, with full recovery within 4 weeks. Hepatotoxicity was not observed.Conclusions:Together, the compelling antitumor efficacy, pathologic CRs, and mild and transient toxicity profile demonstrate strong potential for clinical translation of [177Lu]Lu-DTPA-CHX-A”-SC16.
Helicobacter pylori
Infection Is Associated With Carotid Intima and Media Thickening: A Systematic Review and Meta‐Analysis
Authors: Simon Orsolya Anna , Görbe Anikó , Hegyi Péter , Szakó Lajos , Oštarijaš Eduard , Dembrovszky Fanni , Kiss Szabolcs , Czopf László , Erőss Bálint , Szabó Imre 
Published: January 2022

Background

Helicobacter pylori
(
H. pylori
) infection affects ≈4.4 billion people worldwide. Several studies suggest that this pathogen impacts the digestive system, causing diverse and severe conditions, and results in extragastrointestinal disorders like vascular diseases. Our study aims to examine the association between
H. pylori
infection and carotid intima‐media thickness.

Methods and Results

Electronic databases (MEDLINE, Embase, CENTRAL, Web of Science, and Scopus) were searched for studies, comparing the thickness of the carotid intima‐media in
H. pylori
–infected and noninfected individuals listed until October 20, 2020. Statistical analyses were performed using the random effects meta‐analysis of model of weighted mean differences with the corresponding 95% CI using the DerSimonian and Laird method. The protocol was registered in advance in PROSPERO (International Prospective Register of Systematic Reviews; CRD42021224485). Thirteen studies were found meeting inclusion criteria for our systematic review and meta‐analysis, presenting data on the thickness of the carotid intima‐media considering the presence of
H. pylori
infection. Altogether, 2298 individuals’ data were included (1360
H. pylori
positive, 938 negative). The overall carotid intima‐media thickness was significantly larger among infected patients compared with uninfected participants (weighted mean difference: 0.07 mm; 95% CI, 0.02–0.12;
P
=0.004; I
2
=91.1%;
P
<0.001). In case of the right common carotid artery, the intima‐media thickening was found to be significant as well (weighted mean difference, 0.08 mm; 95% CI, 0.02–0.13,
P
=0.007; I
2
=85.1%;
P
<0.001), while it showed no significance in the left common carotid artery (weighted mean difference, 0.12 mm; 95% CI, −0.05 to 0.28,
P
=0.176; I
2
=97.4%;
P
<0.001).

Conclusions

H. pylori
infection is associated with increased carotid intima‐media thickness. Therefore, the infection may indirectly contribute to the development of major vascular events.
An Intersectional Perspective on Female Mobility in the Hebrew Bible
Authors: Uusimäki Elisa 
Published: January 2022

Abstract
This article explores literary representations of female mobility in the Hebrew Bible. While it is often assumed that women barely moved in the ancient world, the study shows that the Hebrew Bible gives witness to a vast spectrum of travelling agents. The texts do not offer direct access to socio-historical realities, but as documents of cultural history, they are argued to hint at and echo the variety of the phenomenon in ancient Israel. It is not meaningful to speak of the travelling women as a collective, however, as the motives for their movement are tied to various socioeconomic contexts, ranging from slavery to economic migration to foreign policy. While class is fundamental to ancient female mobility, the sources also reveal the significance of other intersecting differences such as age, sexuality, kinship, ethnicity, or religion displayed by the (in)voluntary travelling agents.
The Quest for Equal Rights: The Women’s Movement in Germany and its Care-based Argumentation
Authors: Dechert Andre , Kinnebrock Susanne 
Published: January 2022

Abstract
Building upon the Three-Level Model of the Public Sphere, we (a) analyse how women’s associations in Germany, both during the Wilhelmine era and in the days of the early Federal Republic of Germany, interlinked women’s care work with demands for equality, and (b) examine the public responses to women’s associations’ use of care as the basis for their argumentation. To accomplish these goals, we discuss the results of a standardised content analysis of three feminist magazines from these two eras (Centralblatt, Welt der Frau, and Informationen für die Frau) and supplement the results with a historical-hermeneutic analysis of selected articles, an approach that provides contextualised and detailed insights. Furthermore, we analyse the corresponding discourse in mass media and politics by focusing on major legislative changes and presenting the results of our hermeneutic analysis of selected articles from two periodicals with a strong focus on socio-political issues (Die Hilfe and Der Spiegel).
Disparities in the Diagnosis, Treatment, and Survival Rate of Cervical Cancer among Women with and without Disabilities
Authors: Choi Jin Young , Yeob Kyoung Eun , Hong Seung Hwa , Kim So Young , Jeong Eun-Hwan , Shin Dong Wook , Park Jong Heon , Kang Gil-won , Kim Hak Soon , Park Jong Hyock , Kawachi Ichiro 
Published: January 2022

Introduction Not much is known regarding the disparities in cancer care between women with and without disabilities. Objectives The aim of this study was to investigate the potential disparities in the diagnosis, treatment, and survival of women with cervical cancer with and without disabilities. Methods We performed a retrospective cohort study and linked the National Disability Database, Korean Central Cancer Registry, and Korean National Health Insurance claims database. Charlson comorbidity index was used for adjusting the comorbidity. The study population comprised 3 185 women with disabilities (physical/brain, communication, mental, cardiopulmonary, and other impairment) who were diagnosed with cervical cancer and 13 582 age- and sex-matched women without disability who were diagnosed with cervical cancer for comparison. Results Distant metastatic stage (7.7% vs 3.7%) and unknown stage (16.1% vs 7.0%) were more common in cervical cancer women with grade 1 disabilities, compared with women without disabilities. Women with cervical cancer with disabilities were less likely to undergo surgery (adjusted odds ratio (aOR) 0.81, 95% confidence interval (CI) 0.73–0.90) or chemotherapy (aOR 0.86, 95% CI 0.77–0.97). Lower rate of surgery was more evident in patients with physical/brain impairment (aOR 0.46, 95% CI 0.37–0.58) and severe mental impairment (aOR 0.57, 95% CI 0.41–0.81). The overall mortality risk was also higher in patients with disabilities (adjusted hazard ratio (aHR) 1.36, 95% CI 1.25–1.48). Conclusion Women with cervical cancer with disabilities, especially with severe disabilities, were diagnosed at later stages, received less treatment, and had higher mortality rates, compared with patients who lacked disabilities. Social support and policies, along with education for women with disabilities, their families, and healthcare professionals, are needed to improve these disparities.
Facilitators and barriers to using telepresence robots in aged care settings: A scoping review
Authors: Hung Lillian , Wong Joey , Smith Chelsea , Berndt Annette , Gregorio Mario , Horne Neil , Jackson Lynn , Mann Jim , Wada Mineko , Young Erika 
Published: January 2022

Social isolation has been a significant issue in aged care settings, particularly during the COVID-19 pandemic, and is associated with adverse outcomes, including loneliness, depression, and cognitive decline. While robotic assistance may help mitigate social isolation, it would be helpful to know how to adopt technology in aged care. This scoping review aims to explore facilitators and barriers to the implementation of telepresence robots in aged care settings. Following the Joanna Briggs Institute scoping review methodology and the PRISMA extension for scoping reviews reporting guidelines, we searched relevant peer-reviewed studies through eight databases: CINAHL, MEDLINE, Cochrane, PsychINFO (EBSCO), Web of Science, ProQuest Dissertations and Theses Global, IEEE Xplore, and ACM Digital Library. Google was used to search gray literature, including descriptive, evaluative, quantitative, and qualitative designs. Eligibility includes: studies with people aged 65 years and older who interacted with a telepresence robot in a care setting, and articles written in English. We conducted a thematic analysis to summarize the evidence based on the constructs in the Consolidated Framework of Implementation Research. Of 1183 articles retrieved, 13 were included in the final review. The analysis yielded three themes: relative advantages, perceived risks and problems, and contextual considerations. The key facilitators to telepresence robot adoption are as follows: a feeling of physical presence, ease of use, mobility, and training. The barriers to implementation are as follows: cost, privacy issues, internet connectivity, and workflow. Future research should investigate the role of leadership support in implementation and practical strategies to overcome barriers to technology adoption in aged care settings.
The Impact of Prior Bariatric Surgery on Outcomes After Spine Surgery: A Systematic Review and meta-Analysis
Authors: Alhammoud Abduljabbar , Dalal Sidhant , Sheha Evan D. , Habibullah Nilofer Khan , Moghamis Isam Sami , Virk Sohrab , Gang Catherine Himo , Qureshi Sheeraz A 
Published: January 2022

Study design Systematic review and meta-analysis. Objective To compare outcomes and complication rates in patients undergoing bariatric surgery (BS) prior to spine surgery. Methods A systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines comparing the outcomes of spine surgery between subjects with prior bariatric surgery to those who were considered obese with no prior bariatric surgery. Results A total of 183, 570 patients were included in the 4 studies meeting inclusion criteria. The mean patient age was 52.9 years, and the majority were female (68%). The two groups consisted of a total of 36, 876 patients with prior BS and 146, 694 obese patients without prior BS. The overall rate of complications in the prior BS group was 6.4% (4.5%–38.7%) compared to 11.9% (11.2%–55.4%) in the non-prior BS obese group with a statistically significant difference between the two groups. The prior BS group had lower rates of renal, neurological, and thromboembolic complications, with a lower mortality and readmission rate. In a subgroup undergoing cervical spine surgery, patients with prior BS had fewer cardiac, GI, and total complications. For patients undergoing thoracolumbar spine surgery, patients with prior BS had fewer thromboembolic and total complications. Conclusion Patients undergoing bariatric surgery prior to spine surgery had fewer renal, neurological, and thromboembolic complications as well as a decreased mortality and readmission rate.
Comparison of Suture-Button Fixation with Suture-Tape Augmentation and Trans-Syndesmotic Screw Fixation for Syndemosis Injury: A Biomechanical Study
Authors: Lee Hong Seop , Lee Hong S. , Young Ki Won , Lee Young Koo , Kim Woo Jong 
Published: January 2022

Category: Ankle; Basic Sciences/Biologics Introduction/Purpose: The treatment of syndesmotic injuries with ankle fractures is controversial. The purpose of this study was to compare the biomechanical properties of suture-button fixation with suture-tape augmentation with those of screw fixation. Methods: Ten matched pairs of human cadaver specimens were subjected to suture-button fixation with suture-tape augmentation or screw fixation. Each specimen underwent initial intact physiologic loading, consisting of 10 cycles of axial loading with peak of 750N, 10 cycles of external torsional loading with peak of 7.5Nm, and 10 cycles of combined axial and external torsional loading with peak of 750N and 7.5Nm at 0.05 Hz. Injuries of the anterior inferior tibiofibular ligament, tibiofibular interosseous membrane, posterior tibiofibular ligament and medial malleolar fracture were applied to each specimen. Postfixation cyclic loading consisted of 50 cycles of combinedaxial and external rotation loading with peak torques of 750 N and 7.5 Nm at a rate of 0.05 Hz. After postfixation loading, each specimen underwent failure loading by external rotation at 0.25 degrees/second. Failure torque and failure angle were measured. Results: Mean failure torques were 15.99 +- 8.88 Nm in the suture-button fixation with suture-tape augmentation and 17.10 +- 10.38 Nm in the screw group. There was no significant difference in average failure torque between two groups (p-value = 0.669)Average failure angle in screw-fixation group (39.37 +- 10.19 deg) was significantly lower than average failure angle suture- button fixation with suture-tape augmentation (56.64 +- 9.64 deg) (p-value = 0.001).Average rotational stiffness in screw-fixation group (0.53 +- 0.24 Nm/deg) was significantly higher than average rotational stiffness in suture-button fixation with suture-tape augmentation group (0.35 +- 0.19 Nm/deg) (p-value = 0.033). Conclusion: Suture-button fixation with suture-tape augmentation for ankle syndesmotic injury provides similar torsional strength to that of screw fixation and has lower stiffness than screw fixation. Therefore, Suture-button fixation with suture-tape augmentation can be considered as an alternative treatment option for syndesmosis injury.
Bulk Osteochondral Allograft for Osteochondral Lesions of the Talus: A Systematic Review
Authors: Azam Mohammad , Davey Martin S. , Colasanti Christopher , Mercer Nathaniel P. , Hurley Eoghan T. , Shimozono Yoshiharu , Kennedy John G. 
Published: January 2022

Category: Ankle Introduction/Purpose: The use of bulk osteochondral allograft (OCA) is often warranted in patients with a large osteochondral lesion of the talus (OLT). Previous literature reported that bulk OCA has high failure and revision rates, suggesting these procedures should be thought of as an intermediate step, buying time before arthrodesis or arthroplasty is required. However, recent studies suggest that the long-term survival of bulk OCA has improved and that these procedures may provide a definitive solution for large OLT. The purpose of this study was to systematically review the literature to ascertain the outcomes of bulk OCA for OLT. Methods: Two independent reviewers performed the literature search based on PRISMA guidelines, utilizing the EMBASE, MEDLINE, and The Cochrane Library Databases. Studies were included if they reported outcomes of OLTs which were managed by bulk OCA. Results: Overall, 9 studies with 112 patients (55.4% males) including 115 ankles with a mean follow-up of 72.7 (8 - 240) months were included in this review. Pre-operative OLT characteristics showed that 68.4% were medial lesions, with a mean lesion size of 3.04cm2 (0.7 - 6.1 cm2). Overall, 23.5% of patients required revision surgery following bulk OCA; 10.4% (12/115) underwent subsequent arthrodesis, 1.7% (2/115) underwent revision osteochondral grafting and 9.6% (11/115) underwent arthroscopic debridement. Radiological outcomes reporting graft failure was 21.3% (13/61), joint space narrowing was 25.2% (29/115) and cysts were present in 19.5% (15/77) of cases. Conclusion: Patients experience satisfactory patient-reported clinical outcomes in the medium term following bulk OCA in the management of OLT. Despite recent advances in graft procurement and storage radiological graft failure and the requirement for additional surgeries still remain. At this time can only be recommended in cases that are refractory to other treatments and where the patient is aware that this may be a temporizing procedure before arthroplasty or arthrodesis.