bluuebunny/crossref_metadata_2025_split huggingface dataset:
Debonding‐On‐Demand Polymeric Wound Patches for Minimal Adhesion and Clinical Communication
Authors: Zeng Qiankun , Wang Fangbing , Hu Ruixuan , Ding Xuyin , Lu Yifan , Shi Guoyue , Haick Hossam , Zhang Min 
Published: August 2022

AbstractHerein, a multifunctional bilayer wound patch is developed by integrating a debonding‐on‐demand polymeric tissue adhesive (DDPTA) with an ionic conducting elastomer (ICE). As a skin adhesive layer, the DDPTA is soft and adherent at skin temperature but hard and non‐tacky when cooled, so it provides unique temperature‐triggered quick adhesion and non‐forced detachment from the skin. During use, the dense surface of the DDPTA prevents blood infiltration and reduces unnecessary blood loss with gentle pressing. Moreover, its hydrophobic matrix helps to repel blood and prevents the formation of clots, thus precluding wound tearing during its removal. This unique feature enables the DDPTA to avoid the severe deficiencies of hydrophilic adhesives, providing a reliable solution for a wide range of secondary wound injuries. The DDPTA is versatile in that it can be covered with ICE to configure a DDPTA@ICE patch for initiating non‐verbal communication systems by the fingers, leading toward sign language recognition and a remote clinical alarm system. This multifunctional wound patch with debonding‐on‐demand can promote a new style of tissue sealant for convenient clinical communication.
Downy mildew resistance and genetic variability in a wild rocket germplasm collection
Authors: Coelho Paula S. , Reis João M. , Pereira Ana L. , Vairinhos Aliana , Lopes Violeta , Leitão José M. 
Published: August 2022

AbstractOne hundred accessions of a “core collection” of Diplotaxis tenuifolia (L.) DC. and Eruca spp. were screened at seedling stage for resistance to downy mildew. Accessions tested at the seedling stage were assigned to 0–6 interaction phenotypes. All cultivated rocket (Eruca spp.) accessions exhibited a resistant (R) response both in cotyledons and in young leaves. The wild rocket (D. tenuifolia) accessions exhibited higher susceptibility in cotyledons than in the 1st and 2nd leaves, with 16 and 47 accessions classified as resistant or partially resistant (PR) in the cotyledon and in leaves stages, respectively. Only three wild rocket accessions displayed an R phenotype in cotyledons and leaves. The most frequent response in cotyledons vs. leaves was the highly susceptible/susceptible (HS/S) combination (33 accessions), followed by the S/PR combination (18 accessions). A significant correlation (r = 0.917, P < .000) was observed between the disease index in cotyledons and leaves. The molecular markers analyses revealed a wide genetic distance between Diplotaxis and Eruca, which gather in two clearly separated species clusters. The molecular variability is accompanied by a wide diversity of interactions with the pathogen isolate. The closest similarities among D. tenuifolia accessions were found in accessions provided by the same breeding company. Future studies will be focused on two main objectives: (a) the assessment of the accessions behavior that have evidenced an R/R, S/PR, and HS/PR cotyledon and leaf response under greenhouse or field production and (b) the genome mapping of genetic features that provide downy mildew resistance.
High‐Humidity Shaker Aging to Access Chitin and Cellulose Nanocrystals**
Authors: Jin Tony , Liu Tracy , Hajiali Faezeh , Santos Madison , Liu Yali , Kurdyla Davis , Régnier Sophie , Hrapovic Sabahudin , Lam Edmond , Moores Audrey 
Published: August 2022

AbstractTo unlock nature's potential for functional biomaterials, many efforts have been devoted to isolating the nanocrystalline domains within the supramolecular structure of polysaccharides. Yet, low reactivity and yield in aqueous systems along with excessive solvent usage hinders its development. In this report, the first solvent‐free pathway to access carboxylated chitin and cellulose nanocrystals with excellent mass balance is described, relying on a new method coined high‐humidity shaker aging (HHSA). The method involves a mild grinding of the polysaccharide with ammonium persulfate followed by an aging phase under high‐humidity and on a shaker plate. Insights into the mechanism were uncovered, which highlighted the unique role of high humidity to afford a gradual uptake of water by the material up to deliquescence when the reaction is complete. This process was then validated for direct synthesis of nanocrystals from biomass sources including crab and soft wood pulp.
Controlled/slow‐release fertilizer based on cellulose composite and its impact on sustainable agriculture: review
Authors: Firmanda Afrinal , Fahma Farah , Syamsu Khaswar , Suryanegara Lisman , Wood Kathleen 
Published: August 2022

AbstractThe increase in global population puts pressure on food supplies in the agricultural sector, whose productivity depends on the soil nutrient availability. This demand has an impact on the high chemical fertilizer consumption. Simultaneously, another problem arises owing to unsustainable agricultural practices, namely low fertilizer efficiency. Controlled/slow‐release (CRF/SRF) fertilizers using cellulose biopolymers as composite matrices are a sustainable prospect owing to their being abundant, renewable, and biodegradable. Furthermore, cellulose contains surface chemical properties that are easily modified to play a role in the fertilizers’ release. In addition, the high cellulose hydrophilicity helps maintain soil moisture for plant growth. This article reviews the prospects of cellulose and its derivatives for CRF/SRF development, including cellulose modification, slow/controlled‐release mechanisms, and their impact on sustainable agricultural practices, which are discussed based on environmental, economic and social aspects. In addition, selecting environmentally friendly and low‐cost technologies is a concern to support sustainability. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
Determination of rivaroxaban in rat plasma by ultra‐high‐performance liquid chromatography–Q‐Orbitrap high‐resolution mass spectrometry and its application to a pharmacokinetic study
Authors: Qian Jing , Gu Shun‐zhong , Yan Yong‐jin 
Published: August 2022

AbstractTherapeutic drug monitoring is critical to decrease the incidence rate of bleeding and thrombosis for personalized treatment with rivaroxaban, especially for drug interaction treatment, patients with renal dysfunction, elderly patients, patients with cardiovascular problems, and so on. In addition, an accurate analytical method is necessary for therapeutic drug monitoring. This study developed a ultra‐HPLC–tandem Orbitrap high‐resolution MS (UHPLC–Q‐Orbitrap HRMS) method to accurately identify and quantify rivaroxaban in rat plasma. The isotope internal standard method was applied for accurate quantification. Rivaroxaban‐d4 was selected as the isotope internal standard substance. The m/z 436.07263 ([M + H]+) was selected as the precursor ion and m/z 144.95085 and m/z 231.11259 were selected as the main product ions for rivaroxaban. The lower limit of quantification of rivaroxaban in plasma was 0.01 mg/L. The intra‐ and inter‐day precisions were ≤3.65% and ≤8.16%, while the recoveries ranged from 87.4% to 95.2%. This analysis method was simple, low cost, and easy to operate. The developed and validated method was subsequently applied to successfully investigate the pharmacokinetic parameters of rivaroxaban in rats after its oral administration. These results could be helpful to promote further research regarding the mechanisms of rivaroxaban and drug interaction, which can avoid false positives due to high‐precision identification of the proposed method.
Green capabilities, green purchasing, and triple bottom line performance: Leading toward environmental sustainability
Authors: Khan Syed Abdul Rehman , Yu Zhang , Farooq Khalid 
Published: August 2022

AbstractDespite the vast literature on green purchasing practices and sustainability, the role of an organization's green capabilities in defining green purchasing practices for triple‐bottom‐line performance has received limited attention. This research intends to empirically evaluate the impact of green capabilities on green purchasing practices to boost the triple‐bottom‐line performance of manufacturing organizations. We analyzed 386 manufacturing organizations' responses using the covariance‐based structural equation modeling approach. The results indicate a positive correlation between green capabilities and purchasing habits; however, green innovation capabilities did not establish a statistically meaningful correlation. Additionally, green buying strategies have significant favorable associations with the triple bottom line of performance. The results contributed to the advancement of the resource‐based‐view theory by empirically examining the impact of green capabilities and green purchasing practices in influencing the triple‐bottom‐line performance of manufacturing firms.
Therapist + Social Media = Mental health influencer? Considering the research focusing upon key ethical issues around the use of social media by therapists
Authors: White Ella , Hanley Terry 
Published: August 2022

AbstractCurrent ethical guidelines for therapists who make use of social media are very limited. As a consequence, they leave much open to interpretation by professionals, an openness that may place the public and professionals at risk. This is particularly of note as therapists are increasingly making use of social media and many professionals are taking on roles as mental health influencers, both purposefully and without realising. Such developments raise many important ethical issues including considerations around influencer competency, integrity, the maintenance of confidentiality and risk management. These issues are briefly discussed in this paper alongside related current research focusing upon them. It is concluded that, despite the existence of ethical guidelines focusing upon social media use by therapists, current research suggests that therapists are not consistently following these guidelines. Moreover, it is argued that researchers and professional bodies, and their associated good practice guidelines, need to keep abreast of new developments to account for changes in social media usage.
Phytochemical Analysis and Antibacterial Activity of Achillea coarctata Poir. Essential Oils
Authors: Stamenković Jelena G. , Petrović Goran M. , Đorđević Aleksandra S. 
Published: August 2022

AbstractEssential oils obtained from different parts of Achillea coarctata species (inflorescences, stem and leaves and the whole aerial part) collected on four different locations in Serbia have been investigated to evaluate the chemical composition and antibacterial activity of isolated oils. The aim of this study was to determine differences in the chemical composition of essential oils obtained from different plant parts and how different type of substrate as well as different climate conditions affect the chemical composition of essential oils. Oxigenated terpenes were reported to be the major constituents in almost all examinated samples with 1,8‐cineole, caryophyllene oxide and cis‐cadin‐4‐en‐7‐ol identified as dominant compounds. Disk diffusion assay was used to determine antibacterial activity against two Gram‐positive (Bacillus subtilis subsp. spizizenii ATCC 6633 and Staphylococcus aureus ATCC 6538) and three Gram‐negative bacteria (Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 9027 and Salmonella abony ATCC 6017). The obtained results showed that essential oils obtained from A. coarctata exhibit significant antibacterial activity against tested bacteria strains. The best inhibitory effect was observed against S. aureus, while on the other hand P. aeruginosa showed high level of resistance to almost all examined essential oils.
Synthetic Approaches to Break the Chemical Shift Degeneracy of Glycans
Authors: Dal Colle Marlene C. S. , Fittolani Giulio , Delbianco Martina 
Published: August 2022

AbstractNMR spectroscopy is the leading technique for determining glycans’ three‐dimensional structure and dynamic in solution as well as a fundamental tool to study protein‐glycan interactions. To overcome the severe chemical shift degeneracy of these compounds, synthetic probes carrying NMR‐active nuclei (e. g., 13C or 19F) or lanthanide tags have been proposed. These elegant strategies permitted to simplify the complex NMR analysis of unlabeled analogues, shining light on glycans’ conformational aspects and interaction with proteins. Here, we highlight some key achievements in the synthesis of specifically labeled glycan probes and their contribution towards the fundamental understanding of glycans.
Photo‐Oxidizing Ruthenium(II) Complexes with Enhanced Visible‐Light Absorption and G‐quadruplex DNA Binding Abilities
Authors: Gillard Martin , Piraux Guillaume , Daenen Martin , Abraham Michaël , Troian‐Gautier Ludovic , Bar Laure , Bonnet Hugues , Loiseau Frédérique , Jamet Hélène , Dejeu Jérôme , Defrancq Eric , Elias Benjamin 
Published: August 2022

AbstractPhotosensitizers that gather high photo‐oxidizing power and strong visible‐light absorption are of great interest in the development of new photo‐chemotherapeutics. Indeed, such compounds constitute attractive candidates for the design of type I photosensitizers that are not dependent on the presence of oxygen. In this paper, we report on the synthesis and studies of new ruthenium(II) complexes that display strong visible‐light absorption and can oxidize guanine residues under visible‐light irradiation, as evidenced by nanosecond transient absorption spectroscopy. The reported compounds also tightly bind to G‐quadruplex DNA structures from the human telomeric sequence (TTAGGG repeat). The kinetic and thermodynamic parameters of the interaction of these Ru(II) complexes with G‐quadruplex and duplex DNA were studied thanks to luminescence titrations and bio‐layer interferometry measurements, which revealed higher affinities towards the non‐canonical G‐quadruplex architecture. Docking experiments and non‐covalent ionic analysis allowed us to gain information on the mode and the strength of the interaction of the compounds towards G‐quadruplex and duplex DNA. The different studies emphasize the substantial influence of the position and the number of non‐chelating nitrogen atoms on the interaction with both types of DNA secondary structures.
Tetrasodium iminodisuccinate as a biodegradable complexing agent for remediating metal‐contaminated soil
Authors: He Weijing , Hu Xiaojun , Sun Liqi , Wang Bo , Xing Haibo , Li Kan , Zhang Hongbo 
Published: August 2022

AbstractSoil washing is a rapid and cost‐effective method to treat contaminated soils. However, conventional chelating agents exhibit adverse environmental effects. Tetrasodium iminodisuccinate (IDS) is a new type of amino carboxyl chelating agent, which exhibits strong chelating performance, high solubility in aqueous solution, and is environmentally friendly in soil. In this study, batch washing of Cu, Pb, and Cd removal from simulated contaminated soil and real project‐scale soil of a Pb‐polluted field was explored to evaluate the application of IDS in the remediation of potentially toxic metal‐contaminated soil. The effects of the IDS solution pH, concentration, reaction temperature, liquid/soil (L/S) ratio, number of washing cycles, and contact duration were investigated, and the optimal conditions were identified as follows: pH 7, IDS concentration 10 mmol · L−1, L/S ratio 10:1; 25°C; and 24 h. Almost 80.6% of Cu, 71.1% of Pb, and 59.1% of Cd were removed from simulated contaminated soil under optimal conditions. The primary potentially toxic metal removal mechanisms were analyzed by potentially toxic metal state detection before and after IDS washing. Real project‐scale Pb‐polluted field washing was demonstrated under the same conditions in addition to the IDS concentration of 4.5 mmol · L−1. The Pb concentration was reduced from 460 to 86.8 mg · kg−1 (mean value), which is below the threshold identified in the ‘Risk Assessment of Soil Environmental Health in Shanghai’ (Residential Area, 140 mg · kg−1). The results confirm that IDS is a promising soil washing agent that can effectively remove potentially toxic metals from contaminated soil and minimize environmental risks.
Analysis of the distribution of vagal afferent projections from different peripheral organs to the nucleus of the solitary tract in rats
Authors: Bassi Jaspreet K. , Connelly Angela A. , Butler Andrew G. , Liu Yehe , Ghanbari Anahita , Farmer David G. S. , Jenkins Michael W. , Melo Mariana R. , McDougall Stuart J. , Allen Andrew M. 
Published: August 2022

AbstractAnatomical tracing studies examining the vagal system can conflate details of sensory afferent and motor efferent neurons. Here, we used a serotype of adeno‐associated virus that transports retrogradely and exhibits selective tropism for vagal afferents, to map their soma location and central termination sites within the nucleus of the solitary tract (NTS). We examined the vagal sensory afferents innervating the trachea, duodenum, stomach, or heart, and in some animals, from two organs concurrently. We observed no obvious somatotopy in the somata distribution within the nodose ganglion. The central termination patterns of afferents from different organs within the NTS overlap substantially. Convergence of vagal afferent inputs from different organs onto single NTS neurons is observed. Abdominal and thoracic afferents terminate throughout the NTS, including in the rostral NTS, where the 7th cranial nerve inputs are known to synapse. To address whether the axonal labeling produced by viral transduction is so widespread because it fills axons traveling to their targets, and not just terminal fields, we labeled pre and postsynaptic elements of vagal afferents in the NTS . Vagal afferents form multiple putative synapses as they course through the NTS, with each vagal afferent neuron distributing sensory signals to multiple second‐order NTS neurons. We observe little selectivity between vagal afferents from different visceral targets and NTS neurons with common neurochemical phenotypes, with afferents from different organs making close appositions with the same NTS neuron. We conclude that specific viscerosensory information is distributed widely within the NTS and that the coding of this input is probably determined by the intrinsic properties and projections of the second‐order neuron.
DNA‐Thioguanine Nucleotides as a Marker for Thiopurine Induced Late Leukopenia after Dose Optimizing by NUDT15 C415T in Chinese Patients with IBD
Authors: Zhu Xia , Chao Kang , Yang Ting , Wang Xue‐ding , Guan Shaoxing , Tang Jian , Xie Wen , Yu Ai‐ming , Yang Qing fan , Li Miao , Yang Hong‐sheng , Diao Na , Hu Pin‐jin , Gao Xiang , Huang Min 
Published: August 2022

Thiopurine dose optimization by thiopurine‐S‐methyltransferase (TPMT) or nudix hydrolase‐15 (NUDT15) significantly reduced early leucopenia in Asia. However, it fails to avoid the late incidence (> 2 months). Although laboratory monitoring of 6‐thioguanine nucleotides (6TGN) to optimize thiopurine dose was suggested in White patients the exact association between leucopenia and 6TGN was controversial in Asian patients. In the present study, we aimed to explore whether DNA‐thioguanine nucleotides (DNA‐TGs) in leukocytes, compared with 6TGN in erythrocytes, can be a better biomarker for late leucopenia. This was a prospective, observational study. Patients with inflammatory bowel disease (IBD) prescribed thiopurine from February 2019 to December 2019 were recruited. Thiopurine dose was optimized by NUDT15 C415T (rs116855232). DNA‐TG and 6TGN levels were determined at the time of late leucopenia or 2 months after the stable dose was obtained. A total of 308 patients were included. Thiopurine induced late leucopenia (white blood cells < 3.5 × 109/L) were observed in 43 patients (14.0%), who had significantly higher DNA‐TG concentration than those without leucopenia (P = 4.1 × 10–9, 423.3 (~ 342.2 to 565.7) vs. 270.5 (~ 188.1 to 394.3) fmol/μg DNA). No difference in 6TGN concentrations between leucopenia and non‐leucopenia was found. With a DNA‐TG threshold of 340.1 fmol/μg DNA, 83.7% of leucopenia cases could be identified. Multivariate analysis showed that DNA‐TG was an independent risk factor for late leucopenia. Quantification of DNA‐TG, rather than 6TGN, can be applied to gauge thiopurine therapy after NUDT15 screening in Chinese patients with IBD.
Deep Eutectic Solvent‐Induced In Situ Etching and Phosphorization to Form Nickel Phosphides for Electrooxidation of 5‐Hydroxymethylfurfural
Authors: Xu Danxia , Yang Yuechao , Zhang Baolong , Yang Zhaohui , Liu Shuzi , Mu Tiancheng 
Published: August 2022

AbstractThe development of catalysts with relatively high current densities at low potentials for the electrooxidation of 5‐hydroxymethylfurfural (HMF) is still challenging. In this study, an in situ deep eutectic solvent (DES) etching phosphorization strategy is developed to prepare nickel phosphides encapsulated in P,O‐codoped carbon nanosheets (Ni−P@POC). The DES serves not only as an etchant to extract Ni2+ from the nickel foam, but also as a phosphorus source to form nickel phosphides in situ uniformly embedded in the carbon films to produce a sheet structure. The electrooxidation performance is further greatly improved by implementing an electrochemical activation step to transform Ni−P@POC into NiOOH/Ni−P@POC (t‐Ni−P@POC). t‐Ni−P@POC exhibits a low onset potential of 1.20 V vs. RHE and a high current density of 200 mA cm−2 at 1.33 V vs. RHE for HMF electrooxidation, outperforming most reported catalysts. The as‐developed DES etching phosphorization strategy offers a facile, flexible, and universal route for the design of high‐performance catalysts with specific nanostructures.
Recent advances in liquid biopsy in cancers: Diagnosis, disease state and treatment response monitoring
Authors: Chen Zhixian , Yam Judy Wai Ping 
Published: August 2022

AbstractRecent years have witnessed the development of scientific research and clinical trials of liquid biopsy in various diseases, especially cancers. Liquid biopsy refers to a procedure in which components, including circulating tumour cells (CTCs), cell‐free nucleic acids (cfDNA and cfRNA) and small extracellular vesicles (sEVs), are obtained from blood or other biofluids for analyses. Together with other biocomponents present in liquid biopsies, including CTCs and cell‐free nucleic acids, sEVs are now hotly anticipated as analytical tools and are expected to help identify early‐stage patients and improve cancer patient survival. The independence from tissue availability further confers on liquid biopsy exclusive roles in patient follow‐up and treatment response monitoring. In the past few years, great challenges have been addressed, and remarkable progress has been made in the technologies used for the detection and collection of these biomaterials, enabling liquid biopsy to enter an increasing number of clinical trials and clinical practice. Although problems regarding accuracy and sensitivity remain to be solved, encouraging outcomes have been reported by scientists and clinicians regarding successful applications of liquid biopsy in the prediction of cancer recurrence and responsiveness to specific drugs. Additionally, according to recent reports, this new comprehensive and systematic approach of sampling and analysis shows much potential in non‐tumour fields, such as neurodegenerative and autoimmune diseases. In this review, the current state and latest developments in the applications of different components in liquid biopsy will be discussed, and the use of sEVs in this novel medical strategy will be highlighted.