bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Well, the burden never shifts, but it does’: celebrity, property offences and judicial innovation in Woolmington v DPP
Authors: Crosby K 
Published: July 2022

AbstractIn his 1935 judgment in Woolmington v DPP, Viscount Sankey declared the prosecution's burden of proving the accused's guilt was a ‘golden thread’, running ‘throughout the whole web of English criminal law’. This paper explores what Woolmington can tell us about the appeals process – and about the criminal law itself – less than 30 years after the first automatic right to appeal was created in English criminal law. It argues that the decision helps us understand the political pressures that could help to form – and make possible – legal decisions during this period. And it finds that the Woolmington decision itself – both in the text of the decision and in its immediate reception – was more universal than it was fundamental. Woolmington, I argue, has always been more about the high-level principles of English criminal law than about securing any kind of minimal procedural rights for a defendant.
Psychological distress and unhealthy dietary behaviours among adolescents aged 12–15 years in nine South-East Asian countries: a secondary analysis of the Global School-Based Health Survey data
Authors: Shawon Md Shajedur Rahman , Jahan Esrat , Rouf Rashawan Raziur , Hossain Fariha Binte 
Published: July 2022

AbstractIt is unclear whether there is any association between psychological distress and unhealthy dietary habits among adolescents in low- and middle-income countries. We aimed to estimate the prevalence of these factors in South-East Asia region and investigate their associations. We used data from the Global School-based Health Survey for nine South-East Asian countries. Psychological distress was defined by presence of ≥ 2 factors from loneliness, anxiety, suicide ideation, suicide planning and suicide attempt. We assessed inadequate fruit intake, inadequate vegetable intake, daily soft drink and weekly fast-food consumption. We used random-effects meta-analysis to estimate pooled prevalence. Logistic regressions were used to estimate OR of unhealthy dietary behaviours for psychological distress. Among 30 013 adolescents (56 % girls) aged 12–15 years, the prevalence of psychological distress was 11·0 %, with girls reporting slightly higher than boys (11·8 % v. 10·1 %). The prevalence of inadequate fruit intake, inadequate vegetable intake, daily soft drink consumption and weekly fast-food consumption was 42 %, 26 %, 40 % and 57 %, respectively. Psychological distress was associated with inadequate fruit intake (pooled OR = 1·20, 95 % CI 1·03, 1·40), inadequate vegetable intake (pooled OR = 1·17, 1·05, 1·31) and daily soft drink consumption (pooled OR = 1·14, 1·03, 1·26); but not with weekly fast-food consumption (pooled OR = 1·13, 0·96, 1·31). We observed substantial cross-country variations in prevalence and OR estimates. In conclusion, South-East Asian adolescents have significant burden of psychological distress and unhealthy dietary behaviours, with those having psychological distress are more likely to have unhealthy dietary behaviours. Our findings will guide preventative interventions and inform relevant policies around adolescent nutrition in the region.
Egyptian propolis and selenium nanoparticles against murine trichinosis: a novel therapeutic insight
Authors: Sarhan M.H. , Farghaly A. , Abd El-Aal N.F. , Mohammed Farag S. , Ahmed Ali A. , Farag T.I. 
Published: July 2022

Abstract
Trichinosis is a serious zoonotic disease that causes human morbidity and mortality. New effective natural remedies with minimal side effects that are well tolerated are needed to treat both enteral and parenteral trichinosis. This study evaluated the efficacy of selenium (Se), Se nanoparticles (SeNPs) and Egyptian propolis compared with albendazole as antiparasitic, anti-inflammatory and anti-angiogenic agents for treating murine trichinosis. We used parasitological, histopathological and immunohistochemical assays, as well as scanning electron microscopy, to examine adult worms. Overall, 80 Swiss albino male mice were divided into eight groups, with ten mice in each group, as follows: negative control, positive control, albendazole, propolis, Se, combination of propolis and Se, SeNPs and combination of SeNPs and propolis. Mice were slaughtered seven and 35 days after infection to examine the intestinal and muscular phases, respectively. This study demonstrated the efficacy of the combination of SeNPs and propolis. As revealed by electron microscopy, this combination caused damage to the adult worm cuticle. Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles. In conclusion, the combination of SeNPs and propolis had antiparasitic, anti-inflammatory and anti-angiogenic effects on trichinosis. Consequently, this combination could be used as a natural alternative therapy to albendazole for treating trichinosis.
A Lord’s Prayer inscription from Amorium and the materiality of early Byzantine Christian prayer
Authors: Tsivikis Nikos 
Published: July 2022

AbstractThis article presents an analytical study of a rare example of the text of the Lord’s Prayer inscribed on an early Byzantine ceramic plate that was found in excavations at Amorium. The graffito inscription is discussed in detail and the text identified securely with the Lord’s Prayer as preserved from the Gospels of Mathew and Luke. It is an extremely rare find in Asia Minor. At the same time, the inscribed vessel is examined as an object within its possible context, ecclesiastical, domestic or other, through comparison with other known examples. Finally, the article discusses the possible uses of the Lord’s Prayer in day-to-day life and the materiality of prayer for Christians during the early Byzantine period between the fourth and seventh centuries.
Scheduling servers in a two-stage queue with abandonments and costs
Authors: Zayas-Cabán Gabriel , Cochran Amy L. 
Published: July 2022

AbstractWe consider the assignment of servers to two phases of service in a two-stage tandem queueing system when customers can abandon from each stage of service. New jobs arrive at both stations. Jobs arriving at station 1 may go through both phases of service and jobs arriving at station 2 may go through only one phase of service. Stage-dependent holding and lump-sum abandonment costs are incurred. Continuous-time Markov decision process formulations are developed that minimize discounted expected and long-run average costs. Because uniformization is not possible, we use the continuous-time framework and sample path arguments to analyze control policies. Our main results are conditions under which priority rules are optimal for the single-server model. We then propose and evaluate threshold policies for allocating one or more servers between the two stages in a numerical study. These policies prioritize a phase of service before “switching” to the other phase when total congestion exceeds a certain number. Results provide insight into how to adjust the switching rule to significantly reduce costs for specific input parameters as well as more general multi-server situations when neither preemption or abandonments are allowed during service and service and abandonment times are not exponential.
Heterogeneity of quality of life in young people attending primary mental health services
Authors: Cotton Sue M. , Hamilton Matthew P. , Filia Kate , Menssink Jana M. , Engel Lidia , Mihalopoulos Cathrine , Rickwood Debra , Hetrick Sarah E. , Parker Alexandra G. , Herrman Helen , Telford Nic , Hickie Ian , McGorry Patrick D. , Gao Caroline X. 
Published: July 2022

Abstract

Aims
The utility of quality of life (QoL) as an outcome measure in youth-specific primary mental health care settings has yet to be determined. We aimed to determine: (i) whether heterogeneity on individual items of a QoL measure could be used to identify distinct groups of help-seeking young people; and (ii) the validity of these groups based on having clinically meaningful differences in demographic and clinical characteristics.

Methods
Young people, at their first presentation to one of five primary mental health services, completed a range of questionnaires, including the Assessment of Quality of Life–6 dimensions adolescent version (AQoL-6D). Latent class analysis (LCA) and multivariate multinomial logistic regression were used to define classes based on AQoL-6D and determine demographic and clinical characteristics associated with class membership.

Results
1107 young people (12–25 years) participated. Four groups were identified: (i) no-to-mild impairment in QoL; (ii) moderate impairment across dimensions but especially mental health and coping; (iii) moderate impairment across dimensions but especially on the pain dimension; and (iv) poor QoL across all dimensions along with a greater likelihood of complex and severe clinical presentations. Differences between groups were observed with respect to demographic and clinical features.

Conclusions
Adding multi-attribute utility instruments such as the AQoL-6D to routine data collection in mental health services might generate insights into the care needs of young people beyond reducing psychological distress and promoting symptom recovery. In young people with impairments across all QoL dimensions, the need for a holistic and personalised approach to treatment and recovery is heightened.
Toward a wearable monitor of local muscle fatigue during electrical muscle stimulation using tissue Doppler imaging
Authors: Majdi Joseph A. , Acuña Samuel A. , Chitnis Parag V. , Sikdar Siddhartha 
Published: July 2022

Abstract
Electrical muscle stimulation (EMS) is widely used in rehabilitation and athletic training to generate involuntary muscle contractions. However, EMS leads to rapid muscle fatigue, limiting the force a muscle can produce during prolonged use. Currently available methods to monitor localized muscle fatigue and recovery are generally not compatible with EMS. The purpose of this study was to examine whether Doppler ultrasound imaging can assess changes in stimulated muscle twitches that are related to muscle fatigue from electrical stimulation. We stimulated five isometric muscle twitches in the medial and lateral gastrocnemius of 13 healthy subjects before and after a fatiguing EMS protocol. Tissue Doppler imaging of the medial gastrocnemius recorded muscle tissue velocities during each twitch. Features of the average muscle tissue velocity waveforms changed immediately after the fatiguing stimulation protocol (peak velocity: -38%, p = .022; time-to-zero velocity: +8%, p = .050). As the fatigued muscle recovered, the features of the average tissue velocity waveforms showed a return towards their baseline values similar to that of the normalized ankle torque. We also found that features of the average tissue velocity waveform could significantly predict the ankle twitch torque for each participant (R2 = 0.255–0.849, p < .001). Our results provide evidence that Doppler ultrasound imaging can detect changes in muscle tissue during isometric muscle twitch that are related to muscle fatigue, fatigue recovery, and the generated joint torque. Tissue Doppler imaging may be a feasible method to monitor localized muscle fatigue during EMS in a wearable device.
Influence of exoskeleton use on welding quality during a simulated welding task
Authors: Schalk Marco , Schalk Ines , Bauernhansl Thomas , Siegert Jörg , Esin Alexander , Schneider Urs 
Published: July 2022

Abstract

Purpose
The aim of this study is to investigate the effects of wearing exoskeletons during welding on the quality of the weld seam.

Material and methods
A total of n = 15 young healthy subjects with welding experience took part in the study. The study design defines a 1-hr workflow that abstracts welding and grinding tasks. The sequence is based on standard DIN EN ISO 9606-1 and reproduces authentic work sequences in the constrained body positions PF-workpiece in front of the body and PE-workpiece overhead. Each subject completed the entire workflow once with and once without passive shoulder exoskeleton in a randomized order.

Results
The evaluation shows that the use of passive shoulder exoskeletons has a significant influence (p = .006 for Position PF; p = .029 for Position PE) on the welding parameter travel speed which significantly influences the quality of the weld seam. The quality scale (by the used augmented reality (AR) welding simulator) of the travel speed, which significantly determines the permissibility of the weld, increases by 5.80% in the constrained body position PF and by 28.87% in the constrained body position PE when using an exoskeleton.

Discussion and conclusion
The score of the welding parameter travel speed, which is essential for the permissibility of the seam, shows a statistically significant increase when an assistance system is used. Further research during real welding with exoskeletons could be based on the setup and workflow of this study.
Inter‐Model Spread of North Tropical Atlantic Trans‐Basin Effect Substantially Biases Tropical Pacific Sea Surface Temperature Multiyear Prediction
Authors: Yang Jun‐Chao , Lv Zhen , Richter Ingo , Zhang Yu , Lin Xiaopei 
Published: July 2022

AbstractSea surface temperature (SST) variability in the tropical Pacific (TP) has world‐wide climate and economic influences; hence, improving its prediction is of great interest. Recent modeling studies suggested that north tropical Atlantic variability can influence TP SST variability and prediction. However, models are subject to biases in both the tropical Atlantic and Pacific, and it remains an open question whether these biases affect the trans‐basin linkages and the prediction of TP SST. To investigate this issue, we apply linear inverse modeling to observations and climate models. We find that removing north tropical Atlantic forcing indeed strongly lowers TP SST multiyear prediction skills in observations and models. Models show a large spread of the Atlantic trans‐basin effect, which leads to markedly different TP SST multiyear prediction skills. Our study highlights the necessity to narrow the inter‐model spread for more reliable TP SST multiyear prediction.
Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9
Authors: Li Guodong , Li Dan , Wu Chun , Li Shengnan , Chen Feng , Li Peng , Ko Chung-Nga , Wang Wanhe , Lee Simon Ming-Yuen , Lin Ligen , Ma Dik-Lung , Leung Chung-Hang 
Published: July 2022

AbstractIn hypoxia and hyperglycemia, SET7/9 plays an important role in controlling HIF-1α methylation and regulating the transcription of HIF-1α target genes, which are responsible for angiogenesis and wound healing. Here, we report the Ir(III) complex Set7_1a bearing acetonitrile (ACN) ligands as a SET7/9 methyltransferase inhibitor and HIF-1α stabilizer. Interestingly, Set7_1a could engage SET7/9 and strongly inhibit SET7/9 activity, especially after preincubation with homocysteine (Hcy), which is elevated in diabetes. We hypothesize that Set7_1a exchanges ACN subunits for Hcy to disrupt the interaction between SET7/9 and SAM/SAH, which are structurally related to Hcy. Inhibition of SET7/9 methyltransferase activity by Set7_1a led to reduced HIF-1α methylation at the lysine 32 residue, causing increased HIF-1α level and recruitment of HIF-1α target genes that promote angiogenesis, such as VEGF, GLUT1, and EPO, in hypoxia and hyperglycemia. Significantly, Set7_1a improved wound healing in a type 2 diabetic mouse model by activating HIF-1α signaling and downstream proangiogenic factors. To our knowledge, this is the first Hcy-targeting iridium compound shown to be a SET7/9 antagonist that can accelerate diabetic wound healing. More importantly, this study opens a therapeutic avenue for the treatment of diabetic wounds by the inhibition of SET7/9 lysine methyltransferase activity.
Evaluation of in vivo staging of amyloid deposition in cognitively unimpaired elderly aged 78–94
Authors: Michalowska Malgorzata M. , Herholz Karl , Hinz Rainer , Amadi Chinenye , McInnes Lynn , Anton-Rodriguez Jose M. , Karikari Thomas K. , Blennow Kaj , Zetterberg Henrik , Ashton Nicholas J. , Pendleton Neil , Carter Stephen F. 
Published: July 2022

AbstractAmyloid-beta (Aβ) deposition is common in cognitively unimpaired (CU) elderly >85 years. This study investigated amyloid distribution and evaluated three published in vivo amyloid-PET staging schemes from a cognitively unimpaired (CU) cohort aged 84.9 ± 4.3 years (n = 75). SUV-based principal component analysis (PCA) was applied to 18F-flutemetamol PET data to determine an unbiased regional covariance pattern of tracer uptake across grey matter regions. PET staging schemes were applied to the data and compared to the PCA output. Concentration of p-tau181 was measured in blood plasma. The PCA revealed three distinct components accounting for 91.2% of total SUV variance. PC1 driven by the large common variance of uptake in neocortical and striatal regions was significantly positively correlated with global SUVRs, APOE4 status and p-tau181 concentration. PC2 represented mainly non-specific uptake in typical amyloid-PET reference regions, and PC3 the occipital lobe. Application of the staging schemes demonstrated that the majority of the CU cohort (up to 93%) were classified as having pathological amount and distribution of Aβ. Good correspondence existed between binary (+/−) classification and later amyloid stages, however, substantial differences existed between schemes for low stages with 8–17% of individuals being unstageable, i.e., not following the sequential progression of Aβ deposition. In spite of the difference in staging outcomes there was broad spatial overlap between earlier stages and PC1, most prominently in default mode network regions. This study critically evaluated the utility of in vivo amyloid staging from a single PET scan in CU elderly and found that early amyloid stages could not be consistently classified. The majority of the cohort had pathological Aβ, thus, it remains an open topic what constitutes abnormal brain Aβ in the oldest-old and what is the best method to determine that.
Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest
Authors: Wichmann Johannes , Pitt Catherine , Eccles Samantha , Garnham Alexandra L. , Li-Wai-Suen Connie S. N. , May Rose , Allan Elizabeth , Wilcox Stephen , Herold Marco J. , Smyth Gordon K. , Monahan Brendon J. , Thomas Tim , Voss Anne K. 
Published: July 2022

AbstractHistone acetylation is essential for initiating and maintaining a permissive chromatin conformation and gene transcription. Dysregulation of histone acetylation can contribute to tumorigenesis and metastasis. Using inducible cre-recombinase and CRISPR/Cas9-mediated deletion, we investigated the roles of the histone lysine acetyltransferase TIP60 (KAT5/HTATIP) in human cells, mouse cells, and mouse embryos. We found that loss of TIP60 caused complete cell growth arrest. In the absence of TIP60, chromosomes failed to align in a metaphase plate during mitosis. In some TIP60 deleted cells, endoreplication occurred instead. In contrast, cell survival was not affected. Remarkably, the cell growth arrest caused by loss of TIP60 was independent of the tumor suppressors p53, INK4A and ARF. TIP60 was found to be essential for the acetylation of H2AZ, specifically at lysine 7. The mRNA levels of 6236 human and 8238 mouse genes, including many metabolism genes, were dependent on TIP60. Among the top 50 differentially expressed genes, over 90% were downregulated in cells lacking TIP60, supporting a role for TIP60 as a key co-activator of transcription. We propose a primary role of TIP60 in H2AZ lysine 7 acetylation and transcriptional activation, and that this fundamental role is essential for cell proliferation. Growth arrest independent of major tumor suppressors suggests TIP60 as a potential anti-cancer drug target.
Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
Authors: García-Revilla Juan , Boza-Serrano Antonio , Espinosa-Oliva Ana M. , Soto Manuel Sarmiento , Deierborg Tomas , Ruiz Rocío , de Pablos Rocío M. , Burguillos Miguel Angel , Venero Jose L. 
Published: July 2022

AbstractThe advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are inherently associated with disease conditions. A common feature of some of these activated phenotypes is the upregulation of galectin-3. Representative examples of these phenotypes include disease-associated microglia (DAM) and white-associated microglia (WAM), whose role(s) in neuroprotection/neurotoxicity is a matter of high interest in the microglia community. In this review, we summarise the main findings that demonstrate the ability of galectin-3 to interact with key pattern recognition receptors, including, among others, TLR4 and TREM2 and the importance of galectin-3 in the regulation of microglia activation. Finally, we discuss increasing evidence supporting the involvement of this lectin in the main neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, traumatic brain injury, and stroke.
Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling
Authors: Zhang Weifan , Gong Mengyuan , Zhang Wunai , Mo Jiantao , Zhang Simei , Zhu Zeen , Wang Xueni , Zhang Bo , Qian Weikun , Wu Zheng , Ma Qingyong , Wang Zheng 
Published: July 2022

AbstractFerroptosis is a new form of regulated cell death that is mediated by intracellular iron and ester oxygenase, and glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into nontoxic lipid alcohols. Although thiostrepton (TST) has been reported to exert antitumor effects, its role in pancreatic cancer and the underlying mechanisms remain unclear. In this study, we found that TST reduced the viability and clonogenesis of pancreatic cancer cell lines, along with intracellular iron overload, increasing reactive oxygen species (ROS) accumulation, malondialdehyde (MDA) overexpression, and glutathione peroxidase (GSH-PX) depletion. Mechanistically, chromatin immunoprecipitation (ChIP) and dual luciferase reporter gene assays were used to confirm that signal transducer and activator of transcription 3 (STAT3) binds to the GPX4 promoter region and promotes its transcription, whereas TST blocked GPX4 expression by regulating STAT3. Finally, in vivo experiments revealed that TST inhibited the growth of subcutaneously transplanted tumours and had considerable biosafety. In conclusion, our study identified the mechanism by which TST-induced ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling.