bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the effect of different light intensities in work environments on Circadian rhythm using animal model
Authors: Yekzamani P , Ashtarinezhad A , Aboulghasemi J , Masruri B , Arabian M , Alimohammadi I 
Published: June 2022

Introduction: light intensity and duration are physical factors that affect hormone secretion and circadian rhythms. This study aimed to determine the effects of various light intensities on serum melatonin and cortisol levels.
Materials and methods: This experimental study was carried out on 32 male rats: Group 1 as the control group, received a brightness of 150 lux, and groups 2, 3, and 4 as the exposure groups received light intensities of 300, 5000, and 8000 lux for 14 days, respectively. To evaluate hormone levels, blood samples were taken on before and after 7 and 14 days of exposure. Then cortisol and melatonin levels were determined by ELISA. Data were analyzed using SPSS.
Results: The results showed that cortisol levels after seven days of exposure in the groups exposed to the light intensity of 300, 5000, and 8000 lux increased significantly compared to the control group, and after 14 days, the level of cortisol in the groups. Exposure to a light intensity of 5000 and 8000 lux increased significantly compared to the control. Also, melatonin levels in the group of rats exposed to the light intensity of 5000 lux and 8000 lux after 7 and 14 days of exposure compared to the control significantly decreased.
Conclusion: Increased light intensity is associated with increased melatonin suppression and cortisol levels. It is suggested that more studies be done to prove the effect of different light intensities on changes in the levels of these hormones at varying hours of the day.
Occupational and demographics predictors of musculoskeletal disorders and pain disabilities in construction workers
Authors: Afshari D , Pourerfan P , Nourollahi-darabad M 
Published: June 2022

Introduction: Work-related musculoskeletal disorders are among the most common diseases that cause absenteeism and disability. Exposure to ergonomic risk factors in construction workers increases the risk of discomfort and musculoskeletal disorders in this group. The present study investigates occupational and individual factors predicting musculoskeletal disorders and pain disabilities in construction workers.
Material and Methods: The present cross-sectional study was conducted on 346 construction project workers in Tehran. To study the prevalence of musculoskeletal discomfort, job stress, and pain disabilities, Cornell Musculoskeletal Discomfort Questionnaire, Job Content, and Pain Disability questionnaires were used.
Results: The results of the present study showed that the highest rates of musculoskeletal discomfort were in the neck (68%), left knee (64%), right knee (86%), and back (61%), respectively. The mean score of pain disability was 35.43 ± 20.18, and 16% of people were in severe disability. The results showed that with increasing work experience, working hours per day and body mass index of pain disability increases, and age, work experience, body mass index, and the component of physical needs of the job are the contributing factors of the musculoskeletal discomforts.
Conclusion: Musculoskeletal disorders and pain disability were high in the studied construction workers. Based on the results, age, work experience, body mass index, and job stress contributed to musculoskeletal disorders and pain disabilities. Therefore, this study's results can help to understand better the risk factors affecting musculoskeletal disorders and pain disabilities in construction workers.
Health monitoring in employees exposed to lead: review the evidence
Authors: Davari M.H , Gharavi M , Salmani M , PiriArdakani M 
Published: June 2022

Introduction: Lead is a toxic metal found in the Earth's crust and has been used by humans for 7,000 years due to its high density, flexibility and strength, and low melting point. The widespread use of this metal in industry and the exposure of workers has led to widespread environmental pollution and public health problems in many parts of the world. Due to the widespread use of lead in various occupations and also the importance of complications caused by exposure to it, biological monitoring of employees exposed to this substance has always been of particular importance in occupational medicine and occupational health, so in this article, a review of the latest Changes to the Biological Monitoring Guidelines for Lead Exposed Employees We review recruitment, periodic, and termination surveys.
Method: This study aimed to investigate high-risk occupations and prevent and control lead exposure complications prevent and control lead exposure complications in work environments. GoogleScholar, PubMed, and Scopus databases from 1980 to 2021, and CDC, ACOEM, OSHA, WHO, and ATSDR guidelines were examined by thematic search method. 4 articles and 11 guidelines were selected and used in writing this article.
Results: Studies have shown that many businesses, including manufacturers of lead-acid batteries, ammunition, paints, ceramic glazes, etc., are exposed to lead and its health effects.
Conclusion: To control and prevent the complications caused by exposure to lead, all workers who have occupational exposure to lead should be examined at the beginning of employment and periodically at regular intervals.
Effect of Oral Nirmatrelvir on Long COVID Symptoms: 4 Cases and Rationale for Systematic Studies
Authors: Peluso Michael , Anglin Khamal , Durstenfeld Matthew S. , Martin Jeffrey N. , Kelly J. Daniel , Hsue Priscilla Y. , Henrich Timothy J. , Deeks Steven G. 
Published: June 2022

Background: Efforts to understand the impact of SARS-CoV-2 variants, vaccine status, and treatment on the development and persistence of Long COVID have intensified.
Methods: We report 4 sequential cases from a post-COVID cohort study demonstrating variability in outcomes following differentially timed nirmatrelvir therapy, received as part of clinical care.
Results: In the first case, the participant experienced symptomatic rebound and developed Long COVID despite early initiation of antiviral therapy. In the next 2 cases, participants reported improvement in persistent COVID symptoms when nirmatrelvir was taken 25 and 60 days following initial symptom onset. In the final case, an individual with presumed Long COVID for 2 years reported substantial improvement in chronic symptoms when taking nirmatrelvir following SARS-CoV-2 re-infection.
Conclusions: These anecdotes suggest that systematic study of antiviral therapy for Long COVID is warranted.
Knowledge, Attitudes and Practices of Medical Residents towards Healthcare Ethics in the Islamic Hospital, Jordan
Authors: Abdulrazeq Fayez , Al-Maamari Abdulwahab , Ameen Walaa , Ameen Alaa 
Published: June 2022

Objective: To assess the baseline knowledge, attitudes and practices of medical residents in the Islamic Hospital in Amman, Jordan towards healthcare ethics.
Methods: This was a cross-sectional study conducted among 111 medical residents in the Islamic Hospital in the period from February to April 2017. Data were collected using a self-administered questionnaire, and Pearson’s chi-square test was used to test the statistical significance of differences between male and female medical residents at P values <0.05.
Results: The majority of the respondent medical residents (76.6%) were aware of the content of the Hippocratic Oath. Ethical dilemmas at some point during clinical practice were reported by 68.0% of medical residents; however, only 6.3% reported encountering such dilemmas on a daily basis. Books, lectures and Media were the most frequent sources used by medical residents for learning about healthcare ethics, while supervisors, chiefs of residents and heads of departments were the most frequently preferred for consultation on both ethical and legal problems. The majority (91%) of respondents showed an interest in learning healthcare ethics. However, gaps in knowledge and negative attitudes were observed. Statistically significant differences between male and female residents were found in the issues related to paternalism in case of disagreement with patients/ families, seeking consent for surgeries but not for tests or medications as well as disclosure of tuberculosis-positive status.
Conclusions: There are some gaps in knowledge and negative attitudes towards healthcare ethics among medical residents, where some residents are even unaware of the content of the Hippocratic Oath. Because a substantial proportion of medical residents encounter ethical problems at some point during their clinical practice, there is a necessity to incorporate ethics education into medical curricula, which should be directed at practical real-world dilemmas. Future physicians must learn how to adhere to the four basic principles of healthcare ethics (autonomy, beneficence, justice and nonmaleficence) early in their career.
Keywords: Knowledge, Attitude, Practice, Medical resident, Ethics, Jordan.
Complications of Acute Meningoencephalitis among Children Admitted to Al-Wahda Teaching Hospital in Aden, Yemen
Authors: Bawazeer Iman Mokammed 
Published: June 2022

Objective: To determine the types and frequencies of complications associated with acute meningoencephalitis (ME) among children admitted to hospitals in Aden, Yemen.
Methods: This descriptive cross-sectional study was conducted among 60 children (1 month – 14 years of age) admitted to AL-Wahda Teaching Hospital in Aden with acute ME (viral or bacterial) over the period from January to June 2010. Data were collected using a pre-designed questionnaire, and data were presented as frequencies and percentages and analyzed using appropriate statistical tests. Differences or associations between categorical variables were considered statistically significant at P values <0.05.
Results: ME complications were significantly higher among children aged less than one year compared to those aged one year or older (58.8% vs. 38.5%, respectively) and among those with bacterial ME compared to those with viral ME (79.2% vs. 30.6%, respectively). The complications were also significantly higher among children with history of illness for three or more days before their admission compared to those having been ill for less than three days (65.8 vs. 22.7%, respectively). In addition, children aged less than two years not exclusively breastfed were more prone to ME complications compared to those exclusively breastfed (93.5% vs. 50.0%, respectively). Increased intracranial pressure (ICP), anemia and hypoglycemia were the three most frequent ME complications among children admitted to Al-Wahda Teaching Hospital, being observed in 53.3%, 50.0% and 43.3% of patients, respectively. Increased ICP was significantly higher among children aged five years or older compared to those aged less than five years (88.9% vs. 47.1%, respectively). In contrast, anemia and hyperglycemia were significantly higher among children aged less than five years (56.9% and 49.0%, respectively) compared to those aged five years or older (11.1% each).
Conclusions: ME complications are significantly higher among children aged less than one year, infected with bacterial ME, with history of illness for three or more days before their admission and not exclusively breastfed. Increased ICP, anemia and hypoglycemia are the three most frequent ME complications, particularly among children with bacterial ME in Aden, followed by focal neurological deficits seizures and cranial nerve palsy. Although increased ICP is significantly higher among children aged five years or older, anemia and hyperglycemia are significantly higher among children aged less than five years. Active measures to promote immunization and exclusive breastfeeding along with early diagnosis and proper treatment are highly recommended. Further large-scale studies are required to study the pattern of complications following acute ME among Yemeni children.
Keywords: Meningoencephalitis, Complication, Intracranial pressure, Seizure, Focal neurological sign, Cranial nerve palsy, Yemen.
First Case Report of Primary Testicular Diffuse Large B-Cell Lymphoma from the Western Region of Saudi Arabia
Authors: Albasri Abdulkader , Elkablawy Mohammed A. , Abdelbadie Ahmed , Hussainy Akbar S. , Aljohani Abdelaziz R. 
Published: June 2022

Primary testicular lymphoma (PTL) represents 1-2% of all types of non-Hodgkin lymphomas (NHLs) and 1-10% of testicular neoplasms. Up to the best of my knowledge, this is the first case of PTL of the diffuse large B-cell lymphoma (DLBCL) in a 60-year-old man presented with a painless mass in the left testis as revealed by physical examination in a tertiary care hospital in Al-Madinah Al-Munwarah in the western region of the Kingdom of Saudi Arabia (KSA). Radiological examination revealed a large well-defined heterogeneous predominantly hypo-echoic mass with increased vascularity in the upper portion of the testis. On the other hand, histopathological examination revealed a tumor involving the whole left testis, which was large (measuring 6 3.5 3.3 cm), solid and dark red with focal areas of hemorrhage and epididymal infiltration. Immunohistochemistry showed positivity of leucocyte common antigen (LCA), pan B-cell marker (CD20) and negativity of pan T-cell marker (CD3). Other immunohistochemical markers such as CD10, placental alkaline phosphatase (PLAP), cytokeratin, vimentin, desmin and S100 protein were also negative. However, there was a marked expression of Ki67 and Bcl2 markers. Accordingly, the diagnosis of DLBCL was established. The tumor was classified as stage I according to the Ann Arbor system. The case was treated by orchiectomy followed by prophylactic anthracycline-based chemotherapy and irradiation of the contralateral testis and central nervous system.
Viscoelastic Oil Displacement System of Modified Silica Nanoparticles/Zwitterionic Surfactant for High Salinity Reservoir
Authors: Yan Kun , Liu Changlong , Cao Weijia , Liu Xiaobo , Yao Liming , Su Cheng 
Published: June 2022

AbstractPolymer flooding and polymer/surfactant flooding have achieved good efficiency in the application of conventional reservoir, but the existed chemical flooding technology cannot cannot address the issues of the requirements of chemical flooding in high salinity reservoir. Under the condition of high salinity reservoir, due to the increase of calcium and magnesium ions, the increasing viscosity effect of oil displacement system is lost. In order to study the feasibility of applying nanomaterials in the field of enhanced oil recovery under the conditions of high salinity reservoir, develop a low-concentration and high-efficiency oil displacement system. EAPC solution has advantages in reducing interfacial tension, but its viscosity is not good. Therefore, hydrophobically modified silica nanoparticles (SiO2 NPs) were added to the carboxylic acid–type erucic acid amide propyl betaine (EAPC) solution. The interaction between EAPC and hydrophobic carbon chains led to the exposure of carboxyl groups, thus making the system more stable. The interfacial activity and zeta potential were studied, and the interaction mechanism between modified SiO2 NPs and EAPC was obtained. The results show that when the EAPC concentration is 0.3%, the apparent viscosity of the modified silica nanoparticles (SiO2 NPs) composite system can reach 40 mPa·s, and the oil-water interfacial tension can be reduced to 10-2 mN/m. The micro-visualization model and the simulated oil displacement experiment proved that the modified SiO2 NPs (0.3%)/EAPC (0.3%) composite system has a variety of oil displacement mechanisms. Under the simulated reservoir conditions (total salinity of 25000 mg/L, calcium and magnesium ion concentration of 500 mg/L, 70 °C), it is proved that the modified SiO2 NPs composite system had good viscoelasticity and improved oil washing efficiency. The oil displacement system has guiding significance for effectively enhancing the recovery of high salinity reservoir.
Drug Conjugated Nanomedicine as Prodrug Carrier
Authors: Kumbhani Kerul , Agrawal Yadavendra 
Published: June 2022

:
It is new approach to combine one or multiple drugs onto the same drug-delivery nanocarrier in accurately controllable manner, by covalently preconjugating one or multiple therapeutic agents by covalent bond to form drug conjugates. It provides the advantages of nano size system with the targeted delivery of drug with great precision. The conjugation system allows the modification in the metabolic path way in the blood stream and can target the delivery to the heart, liver or brain. The cleavable covalent bond allows the therapeutic activity of the individual drugs to be resumed after the drug conjugates are delivered into the target site and get separated from the carriers. The characters of drug conjugated system are (a) a covalent bond between drug and carrier moiety, (b) in vitro cleavage of the bond, (c) optimum release of drug at site of action to ensure effectiveness, (d) no alteration in drug action. As a proof of the concept, synthesis and characterization of stearic acid/oleic acid- diminazene conjugates nanoparticles are demonstrated. It is shown that after conjugation with lipid and/or polymer and synthesized to nanoparticles there is significant improvement in cyctotoxicity and targeted controlled delivery of drug than the free drug.
effect of corporate branding, islamic corporate social responsibility (ICSR), ethics programs, on customer loyalty through corporate reputation and spiritual experience
Authors: Lesmana Ceta Indra , Ujianto Ujianto , Halik Abdul 
Published: June 2022

This study was structured as an attempt to test several concepts regarding the variables that affect customer loyalty. Significant support was obtained in testing hypothesis 1 up to 10 which strengthen the concept of corporate brand, Islamic corporate social responsibility, corporate reputation, spiritual experience and customer loyalty. The sample is taken as many as 144 respondents using purposive sampling. Data was collected using a survey method through questionnaires filled out by customers. Then the data obtained were analyzed using sem amos version 26. Hypothesis testing in this study resulted in the company's brand having no significant effect on corporate reputation. Icsr has no significant effect on the company's reputation. Ethics program affects corporate reputation. Corporate branding significantly negative effect on spiritual experience. ICSR has no significant effect on spiritual experience. The company's brand has a negative and significant effect on customer loyalty. Icsr affects customer loyalty. Ethics program affects customer loyalty. Corporate reputation has a significant effect on customer loyalty.
Keywords: Corporate Branding, ICSR, Ethics Program, Corporate Reputation, Spiritual Experience, Customer Loyalty
HARMONIOUS INTERMINGLING BETWEEN SCHOOL SUPERVISORY TEAM AND INDUSTRY TRAINING SPECIALISTS
Authors: KUSNADI Kusnadi 
Published: June 2022

Dual system, as a combined partnership in education between vocational schools and companies is a teeming phenomenon all-over the world. Indonesia is one of the countries that for sometimes has been practicing this system seriously using huge amount of resources all-over the nation. However, the result is not typical for different schools. Originally the researcher was interested in evaluating the implementation of Dual System Program, but after sometimes during qualitative data collection, the researcher was more interested in some important factors affecting the success of dual system. The study shifted to explore key success factors in implementing dual system at YKTB 2 vocational High School in Bogor Indonesia. Using a Discrepancy Evaluation Model (DEM) and beyond, the researcher evaluated the implementation of the System at the Vocational School in Bogor Indonesia and conclude that the success of implementation is very much depends on harmonious association of school supervisory activities and the capability of training specialist in the industry to translate the objective of vocational schools for providing graduates to work in several positions available in the economy.
THE INFLUENCE OF PRINCIPAL ENTREPRENEUR LEADERSHIP AND ORGANIZATIONAL CULTURE ON THE CREATIVITY OF TEACHERS
Authors: ORBANI Afrah Khaiyati , KHULUQO Ihsana El 
Published: June 2022

This research aims to reveal and to study the influence of the principal entrepreneur leadership and organizational culture toward teacher creativity in the Tourism Vocational High Schools in Southern Jakarta. This research is one that is quantitative survey-based employing questionnaires and path analysis. Study population consists of all 226 teachers in those schools, applying Slovin’s formula with sampled teachers amounting 144, and extra 30 teachers trial pre sampled teachers. Method applied in this research is Simple Random Sampling.This research has hypothesis, as follow: (1) there is direct positive influence of the principal entrepreneur leadership toward teacher creativity, (2) there is direct positive influence of the organizational culture toward teacher creativity, and (3) there is direct positive influence of the principal entrepreneur leadership toward organizational culture. Trial instrument is applied to obtain both validity of the statements provided and realibility of the instrument at the same time by using formula provided by Pearson Product Moment and reliabilities calculated by Alpha Cronbach formulation, and every instrument indicated that reliabilities of; teacher’s creativity rii=0.886, principal entrepreneur leadership rii= 0.893 and organization culture rii= 0.909.Furthermore, the big of its influences measured by path analysis formulation for significance level α = 0,05, The result is concluded, zero hypothesis (H0), explained there is not direct positive influence of the principal entrepreneur leadership and organizational culture toward teacher creativity is rejected, while alternative hypothesis (H1), explained there is direct positive influence of the principal entrepreneur leadership and organizational culture toward teacher creativity is accepted.