bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative computed tomography-guided localization for multiple pulmonary nodules: comparison of methylene blue and coil
Authors: Zhang Sheng-Feng , Liu Hai-Ri , Ma Ai-Li , Li Er-Liang 
Published: April 2022

Abstract
Background
Preoperative computed tomography (CT)-guided localization has been used to guide the video-assisted thoracoscopic surgery (VATS) sublobar (wedge or segmental) resection for pulmonary nodules (PNs). We aimed to assess the relative efficacy and safety of CT-guided methylene blue (MB)- and coil-based approaches to the preoperative localization of multiple PNs (MPNs).
Methods
Between January 2015 and December 2020, 31 total cases suffering from MPNs at our hospital underwent CT-guided localization and subsequent VATS resection in our hospital, of whom 15 and 16 respectively underwent MB localization (MBL) and coil localization (CL). The clinical effectiveness and complication rates were compared between 2 groups.
Results
The PN- and patient-based technical success rates in the MBL group were both 100%, whereas in the CL group they were 97.2% (35/36) and 93.8% (15/16), respectively, with no substantial discrepancies between groups. Patients in the MBL group illustrated a substantially shorter CT-guided localization duration compared with the CL group (20.1 min vs. 32.5 min, P < 0.001). Pneumothorax rates (P = 1.000) and lung hemorrhage (P = 1.000) were comparable in both groups. In the MBL and CL groups, the mean interval between localization and VATS was 1.2 h and 11.7 h, respectively (P < 0.001). One-stage VATS sublobar resection of the target nodules was successfully performed in all patients from both groups.
Conclusion
Both CT-guided MBL and CL can be readily and safely utilized for preoperative localization in individuals who had MPNs, with MBL being correlated with a shorter localization duration compared with CL.
Post COVID-19 hyperinflammatory acute kidney injury and background ovarian insufficiency: Renal functional restoration after combined angiotensin-converting enzyme inhibitor with estrogen replacement
Authors: Sills E Scott , Wood Samuel H , Walsh Anthony P H 
Published: April 2022

Abstract
Adolescents with COVID-19 and subsequent multisystem inflammatory injury share key features with Kawasaki disease and toxic shock syndrome. As referenced in a United Nations WHO brief from May 2020, findings from North America and Europe drew notice to an acute illness accompanied by severe, diffuse hyperinflammation leading to multiorgan failure. While females diagnosed with COVID-19 generally have more favorable outcomes than males, this protective effect is negated by any low/absent estrogen state. Our research focuses on secondary amenorrhea from pre-adulthood ovarian insufficiency where RUNX2, SALL1 and SAMD9 variants were identified by exon sequencing in a healthy, phenotypically normal 46,XX adolescent. Against this background, COVID-19 infection occurred necessitating hospital admission where multisystem inflammatory syndrome in children (MIS-C) was diagnosed. Although renal function was compromised secondary to COVID-19 infection, this damage was transient and apparently reversed by angiotensin-converting enzyme inhibitor plus transdermal estrogen replacement therapy. This research is the first to study the intersection of multigene variants, ovarian insufficiency, COVID-19, and acute kidney injury as a component of MIS-C. The background transition from adolescence to adulthood is also considered, where successful recovery of renal function was attained using combined enalapril and supplemental estrogen.
Bioassay of oxidative properties and toxic side effects of apple juice
Authors: Samoylov Artem , Suraeva Natal’ya , Zaytseva Mariya , Petrov Andrey 
Published: April 2022

Introduction. Apple juice owes its beneficial properties to various biologically active compounds, e.g. antioxidants. Therefore, food science needs effective methods that would cover all the mechanisms of their effect on human metabolism. However, fruit juice production raises certain safety issues that are associated not only with production risks, but also with some natural components in the raw material. The Allium cepa test seems to be an effective solution to the problem. This plant bioassay has a good correlation tested on mammalian cell cultures.
Study objects and methods. Onion roots (A. cepa) were treated with aqueous solutions of juices and sorbic acid to assess their antioxidant profile. The toxic effects on root tissues were described according to biomass growth, malondialdehyde (MDA) concentration, and proliferative and cytogenetic disorders.
Results and discussion. The study revealed the optimal conditions for the A. cepa assay of the antioxidant properties of apple juice. The antioxidant activity was at its highest when the juice was diluted with water 1:9 and the onion roots were treated with sorbic acid. The lipid oxidation of the A. cepa roots decreased by 43%. A comparative analysis of three different juice brands showed that the difference in their antioxidant profiles was ≤ 3%. As for toxic side effects, the chromosome aberrations increased by six times in all samples.
Conclusion. The research offers a new in vivo method for determining the antioxidant profile of apple juice. Three juice brands proved to have irreversible cytotoxic and genotoxic effects.
The fate and risk of nontuberculous mycobacteria in the water supply system: a review
Authors: Gan Yalan , Rahmatika Iftita , Kurisu Futoshi , Furumai Hiroaki , Simazaki Dai , Fukano Hanako , Hoshino Yoshihiko , Kasuga Ikuro 
Published: April 2022

AbstractNontuberculous mycobacteria (NTM) infection is estimated as the most serious waterborne infectious disease. NTM are ubiquitous in drinking water supply systems, which could be one of the possible exposure pathways for NTM disease, posing a serious concern to human health. Characteristics of NTM, such as exposure via inhalation, disinfectant resistance, survival in oligotrophic conditions, and association with amoebae, are largely different from those of Escherichia coli (E. coli) which has been traditionally regarded as a model bacterium causing gastrointestinal diseases in water safety. However, the fate of NTM in water supply systems from source water to the point of use has not been systematically revealed yet. Thus, this review proposes that NTM should be regarded as alternative model bacteria in water use by updating the current knowledge on the occurrence, removal efficiency, and regrowth of NTM in water supply systems. Moreover, we demonstrate the need to establish a comprehensive quantitative microbial risk assessment to identify the critical control point, which is indispensable to mitigate NTM risk in water use.
Synthesis and Structure of Hetaryl Substituted 2,5-dioxo-1,2,3,4,5,6,7,8- Octahydroquinolines
Authors: Ozokan Kadri Gokhan , Kaban Seniz 
Published: April 2022

Aims and Objective:Condensation of 5-hetarylidene-2,2-dimethyl-1,3-dioxane-4,6-diones with 5,5-dimethyl-3-arylamino-2-cyclohexanones yields 1-aryl-4-hetaryl-7,7-dimethyl-2,5-dioxo-l,2,3,4,5,5,7,8-octahydro-quinolines. The structures of all the synthesized compounds have been verified by IR, 1H-NMR, 13C-NMR, and mass spectral methods. The 13C-NMR assignments were supported by HSQC and HMBC experiments. Moreover, spin decoupling and NOE experiments have been carried out in order to elucidate stereoisomeric configurations of the compounds. It has been established that the N-phenyl ring, which projects from the plane of the octahydroquinolinedione ring, has a shielding effect on the magnetic field of the protons at 7- and 8-positions of the ring in the molecules of the compounds synthesized.Materials and Methods:The NMR spectra were recorded on a Varian Gemini spectrometer [400 MHz (1H) and 100 MHz (13C)]. EI mass spectra were obtained with a Hewlett Packard GC/MS 6890/5973 machine. MALDI-TOF mass measurements were recorded on a Bruker auto-flex III smart beam.Results:Various reaction conditions were applied in order to find an optimum and convenient procedure for the formation of octahydroquinoline derivates having hetaryl group. The highest yields (40-50 %) were achieved using acetic acid as solvent, p-toluenesulphonic acid as acidic catalyst, and excess enaminone (1.5 equiv).Conclusion:We synthesized eight new 1-aryl-7,7-dimethyl-4-hetaryl-1,2,3,4,5,6,7,8-octahydro-quinoline-2,5-dione compounds containing thienyl core as a result of Michael addition reaction of Knoevenagel products of Meldrum’s acid with dimedone enaminone compounds. Optimum circumstances were established using various reaction conditions and catalyzers throughout the research. The structures of all the synthesized compounds were analyzed by IR, 1H-NMR, 13C-NMR, and mass spectral methods. Furthermore, the structures were verified with the help of 2D (HSQC and HMBC), spin decoupling, and NOE NMR techniques.
Characteristics, Biological Activities, Synthesis, and Methods for the
Determination of Brexpiprazole in Different Matrices
Authors: Shrivastava Alankar , Mittal Ashu , Khabiya Rakhi , Choudhary GP , Darwhekar Gajanan N. 
Published: April 2022

Background:
Brexpiprazole (BRZ) is a "third-generation" antipsychotic dopaminergic
(D2) and 5HT1A (serotonin) partial agonist, approved in July 2015 by the US Food and Drug Administration
for the treatment of the major depressive disorder (MDD) other than schizophrenia in
adults. Antipsychotics are known to produce extrapyramidal effects as side effects. The recent development
in this segment is of piperazine-based antipsychotic BRZ, which is more specific towards
indented indications (depression) and has fewer side effects.

Objective:
To critically review the different analytical methods available in the literature.

Methods:
Eight spectrophotometry-based studies, nineteen chromatography-based studies, and
two other method-based studies were found in the literature search. A brief discussion on pharmacokinetics
and the mechanism of action is also included.

Conclutions:
This review can be used for the development of more robust and suitable analytical
methods for the determination of drugs in different matrices. A brief discussion concerning the
approach towards the advancement of green analytical methods is likewise one of the points of
this review.
COVID-19 and Coinfections: A Serious Health Threat Requires Combination
of Diagnosis and Therapy
Authors: Nawaz Shahid , Saleem Maira 
Published: April 2022

Abstract:
Since the advent of the COVID-19 pandemic in 2019, a mammoth research activity targeting
the etiological features of COVID-19 has commenced. Many aspects of the disease have been studied,
and various others are under consideration. The secondary microbial coinfections with COVID-19
have generated some serious concerns across the globe. This review mainly focuses on the notable
secondary coinfections. The coinfection of influenza, tuberculosis, and typhoid may mimic the original
COVID-19 symptoms. Physicians and clinicians must focus on the secondary coinfections which may
aggravate the disease progression towards acute respiratory disorder syndrome (ARDS). Diagnostic
strategies must also be redefined to determine the actual underlying secondary coinfection. There is a
need for combination therapy and diagnostic approaches to minimize the risks associated with the
COVID-19 pandemic effectively.
Frequency and Correlates of Online Consultations With Doctors or Therapists in Middle-Aged and Older Adults: Nationally Representative Cross-sectional Study
Authors: Hajek André , König Hans-Helmut 
Published: April 2022

Background
A few studies have identified the frequency and correlates of online consultations with doctors or therapists. However, there is a lack of studies using nationally representative data from middle-aged and older adults in Germany.

Objective
This study aims to determine the frequency and correlates of online consultations with doctors or therapists in Germany.

Methods
For this study, cross-sectional data were taken from the nationally representative German Ageing Survey (DEAS; n=3067 in the analytical sample; age range 46-98 years). As part of the DEAS, a short survey was conducted between June 8 and July 22, 2020, examining the everyday life and living conditions among these middle-aged and older individuals during the COVID-19 pandemic. The frequency of online consultations with doctors or therapists served as the dependent variable (daily, several times a week, once a week, 1-3 times a month, less often, and never). Multiple logistic regressions were performed.

Results
In sum, 10.02% (381/3806) of individuals with access to the internet had online consultations with doctors or therapists. Multiple logistic regressions showed that the likelihood of using online consultations with doctors or therapists (compared with those never using such services) was positively associated with higher education (compared with medium education; odds ratio [OR] 1.31, 95% CI 1.01-1.70), living with a partner in the same household (compared with single; OR 1.53, 95% CI 1.05-2.22), poorer self-rated health (OR 1.42, 95% CI 1.16-1.74), increased loneliness (OR 1.45, 95% CI 1.10-1.90), and increased satisfaction with life (OR 1.30, 95% CI 1.03-1.64).

Conclusions
Study findings suggest that a non-negligible proportion of about 1 out of 10 individuals aged 46 years and over had online consultations with doctors or therapists. However, compared with other countries, this proportion remains small. Knowledge about the correlates of (non)use may assist in identifying corresponding individuals. In times of reshaping the health care system, these efforts in online consultations with doctors or therapists may contribute to addressing patient needs. Moreover, increased use of such services may reduce the risk of getting infected with SARS-CoV-2 by reducing social contact.
Sex-based differences in the outcomes of patients with lung carcinoids
Authors: Abdel-Rahman Omar , Ghosh Sunita , Fazio Nicola 
Published: April 2022

Objective:
To assess the impact of sex on the outcomes of patients with well-differentiated lung neuroendocrine neoplasms in a real-world setting.
Methods:
The Surveillance, Epidemiology and End Results Research Plus database (2000–2018) was accessed, and patients with a diagnosis of typical or atypical carcinoid of the lung were reviewed. Trends in age-standardized rates (per 100,000) of the incidence of lung carcinoid tumors were reviewed among male and female patients as well as the overall population, and annual percent change (APC) was determined for the three groups. Multivariate Cox regression analysis was then used to assess the factors associated with overall and cancer-specific survival.
Results:
Among all patients, APC (2000–2018) for lung carcinoid diagnosis was 2.9 (95% CI: 2.4–3.5). Among male patients, APC (2000–2018) for lung carcinoid diagnosis was 1.8 (95% CI: 1.2–2.5). By contrast, among female patients, APC (2000–2018) for lung carcinoid diagnosis was 3.4 (95% CI: 2.8–4.1). Based on Kaplan–Meier survival estimates, female sex was associated with better overall survival compared with male sex (p < 0.001). Based on multivariate Cox regression analysis, the following factors were associated with worse cancer-specific survival: older age (hazard ratio [HR]: 1.036; 95% CI: 1.031–1.041), atypical carcinoid histology (HR: 3.10; 95% CI: 2.71–3.56), stage (distant vs localized stage HR: 4.05; 95% CI: 3.48–4.71), sex (male vs female sex HR: 1.76; 95% CI: 1.56–1.99) and no surgical treatment (HR: 3.77; 95% CI: 3.22–4.42).
Conclusion:
Female patients with lung carcinoid tumors have better overall survival compared with male patients, particularly among patients with typical carcinoid tumors.
Parent knowledge of and attitudes towards youth sport-related concussion and associations with child and parent factors
Authors: Roberts Samantha D , Schatz Phillip , Register-Mihalik Johna , Wojtowicz Magdalena 
Published: April 2022

Aim: This cross-sectional study aimed to better understand parental knowledge and attitudes regarding pediatric sport-related concussions, and association with parent/child biopsychosocial factors. Methods: A community sample of ninety families (n = 140 children) were included. Parental concussion knowledge and attitudes, concussion history, sport participation and social risk status score (SRS) were collected. Results: Parents scored an average of 76% accuracy on factual concussion knowledge, with 74% confidence in responses. Parents endorsed a favorable attitude toward concussion reporting and management. Low SRS had higher perceived accuracy of knowledge than medium or high SRS (p = 0.003). SRS influenced over-and-underestimations of factual knowledge (p = .04). Age at first sport and sport contact level influenced factual and perceived concussion knowledge. Conclusion: These findings identify common gaps in concussion knowledge in parents.
EFFECT OF PER, DER, EPS, AND PBV ON STOCK PRICES IN BANKING COMPANIES ON IDX
Authors: Elieser Abram , Arisandy Aruan Deasy , Dongoran Bintori , Simanjuntak Mariabeth 
Published: April 2022

This research intends to analyze the influence of PER, DER, EPS and PBV on share prices partially and simultaneously in banking companies listed on the IDX for the period 2016- 2019. This finding uses a population of 42 banking companies registered with the IDX for the period 2016 - 2019. This research uses quantitative methods. The secondary datai usedi is obtained from the official website of the www.idx.co.id and www.idnfinancials.com. In this study used for sampling is the Purposive Sampling technique. The method of investigation used is a double linear regression method. The findings showed that PER, DER and EPS partially had a negative and significant effect oni the stocki price, pbv partially had a positive and significant effect on the stock price. Based on simultaneous PER, DER, EPS and PBV significantly affect the stock price in banking companies listed on the Indonesia Stock Exchange (IDX) period 2016-2019
Faktor Pendukung Perilaku Seksual Remaja Di Provinsi Maluku
Authors: Asmin Elpira , Kistiana Sari 
Published: April 2022

Premarital sexual behavior among adolescents of Maluku Province is four percent, which was higher than the national figure, making it the fifth-highest in adolescents’ premarital sexual behavior, after West Papua (10%), Papua (5%), North Sulawesi (5%) and North Maluku (4%). This study is based on the 2019 Adolescents’ Performance and Accountability Survey of Population, Family Planning, and Family Development to analyze the relationship between enabling factors and adolescents’ sexual behavior. This research is a quantitative study, which is correlative analytic with a cross-sectional study approach. The total sample was 241 adolescents age 10-24 years and not married. The analysis found significant factors related to adolescents’ sexual behavior were exposure to family planning information (p = 0.011), exposure to“genre” information (p = 0.015), exposure to STIs information (p <0.001), exposure to HIV / AIDS information (p = 0.001), exposure to drugs information (p = 0.026) and discussion of menstruation / wet dreams (p <0.001). This study suggests a breakthrough innovation in providing information which is not only through mass media but also social media such as Instagram, Facebook, Twitter, YouTube, or reproductive health applications.
Abstrak
Maluku merupakan provinsi yang berada pada urutan kelima dengan persentase hubungan seksual pranikah di kalangan remaja tertinggi, setelah Papua Barat (10%), Papua (5%), Sulawesi Utara (5%) dan Maluku Utara (4%). Angka hubungan seksual pranikah di Provinsi Maluku pada tahun 2019 tiga persen lebih tinggi dari angka nasional, yaitu empat persen. Penelitian ini bertujuan untuk menganalisis faktor pendukung perilaku seksual remaja di Provinsi Maluku berdasarkan data Survei Kinerja dan Akuntabilitas Program Kependudukan, Keluarga Berencana dan Pembangunan Keluarga (SKAP) Remaja Tahun 2019. Penelitian ini merupakan penelitian kuantitatif yang bersifat analitik korelatif dengan pendekatan cross sectional study. Besar sampel dalam analisis 241 remaja yang berusia 10-24 tahun dan belum menikah. Hasil regresi logistik menunjukkan lima variabel keterpaparan informasi yang signifikan berhubungan dengan perilaku seksual remaja, antara lain keterpaparan informasi tentang KB (p=0,011), keterpaparan informasi tentang generasi berencana (p=0,015), keterpaparan informasi tentang IMS (p<0,001), keterpaparan informasi tentang HIV/AIDS (p=0,001), keterpaparan informasi tentang NAPZA (p=0,026) dan diskusi haid/mimpi basah (p<0,001). Disarankan perlunya inovasi dalam saluran pemberian informasi, tidak hanya media massa tetapi juga melalui media sosial seperti Instagram, facebook, twitter, melalui youtube ataupun juga melalui aplikasi khusus mengenai kesehatan reproduksi.
Intervensi Kinesio Taping Dan Bobath Exercises Terhadap Peningkatan Keseimbangan Berdiri Dan Penurunan Spastisitas Tungkai Pasien Cerebral Palsy Di Sekolah Luar Biasa Dan Yayasan Pendidikan Anak Cacat Makassar
Authors: Anwar Suharto , L Sri Saadiyah , Syakib Ahmad 
Published: April 2022

Cerebal Palsy is a non progressive neuromuscular dysfunction in the form of muscle tone abnormalities which results in postural tone disorders in the form of spasticity, especially the legs, coordination disorders, sitting and standing balance, road disturbances that cause sufferers with daily functional impairment. The purpose of this study is to determine the effect of Kinesio taping and Bobath exercises for increasing the ability to balance standing and decrease the spasticity of the patient's limbs. This type of research is a pre-experiment with one group pre-test-post test design. Held at the Special School and the Makassar Disability Children Education Foundation from July to October 2019, with a sample of 49 cerebral palsy patients. Standing balance data were obtained using a Pediatric balance scale and limb spasticity data were obtained using the Asworth scale. Paired sample T Test Results obtained p value = 0.006 for spasticity and standing balance with p = 0.000 after being given Kinesio taping and bobath exercises. The conclusion of the study was that kinesio taping and bobath exercises had no significant effect on leg spasticity and there was a significant effect on the sitting balance of cerebral palsy patients. It is hoped that these two methods can be used in cerebral palsy patients who experience impaired sitting balance.
Abstrak
Cerebal Palsy adalah kelainan fungsi neuromuscular non progresif berupa abnormalitas tonus otot yang mengakibatkan gangguan tonus postural berupa spastisitas terutama tungkai, gangguan koordinasi, keseimbangan duduk dan berdiri, gangguan jalan yang menyebabkan penderita terganggu fungsionalnya sehari-hari. Tujuan penelitian ini mengetahui pengaruh Kinesio taping dan Bobath exercises terhadap peningkatan kemampuan keseimbangan berdiri dan penurunan spastisitas tungkai pasien. Jenis penelitian ini adalah pre - experiment dengan desain pretest – post test one group. Dilaksanakan di Sekolah luar Biasa dan Yayasan Pendidikan Anak Cacat Makassar mulai bulan JulisampaiOktober2019, dengan sampel penelitian sebanyak 49 pasien cerebral palsy. Data keseimbangan berdiri di peroleh menggunakan Pediatric balance scale dan data spastisitas tungkai diperoleh menggunakan skala asworth. Hasil Uji Paired sample T Test diperoleh nilai p = 0.006 untuk spastisitas dan keseimbangan berdiri dengan p = 0.000 setelah diberikan Kinesio taping dan bobath exercises. Kesimpulan penelitian bahwa kinesio taping dan bobath exercises tidak terdapat pengaruh yang signifikan pada spastititas tungkai dan terdapat pengaruh yang signifikan terhadap keseimbangan duduk pasien cerebral palsy. Dengan demikian diharapkan kedua metode ini dapat digunakan pada pasien cerebral palsy yang mengalami gangguan keseimbangan berdiri.