bluuebunny/crossref_metadata_2025_split huggingface dataset:
CaS: Sb3+, Na and ZnS:Sn2+: phosphor materials for the improvement of WLEDs
Authors: Huu Phuc Dang , Phung Ton That 
Published: April 2022

The remote phosphor configuration, though not the best choice for WLED color quality, is superior to the luminous flux of LEDs compared to the conformal or in-cup structures. Realizing the capability of the remote phosphor design, several studies have been done to overcome the drawback of this structure, which is the color quality. A two-film distant phosphor configuration with improved color rendering index (CRI) and color quality ratio (CQS) for WLEDs is offered in this study paper. The hue temperature of the WLEDs packets employed in this research is 8500 K. This phosphor structure is constructed by layering of a green CaS:Sb3+,Na or red ZnS:Sn2+ phosphor above the yellow YAG:Ce3+ phosphor. The additional phosphor ZnS:Sn2+ concentration will then be modified to get the best color quality. The results demonstrated an increase in CRI and CQS along with the presence of ZnS:Sn2+, indicating that the existence of ZnS:Sn2+ influences significantly on these two aspects. As a result of the increased concentration of red illumination elements inside packets, the higher the concentration of ZnS:Sn2+, the higher the CRI and CQS. The green phosphor CaS:Sb3+,Na, in the meantime, improves the luminous flux.
O homem dotado de imagem: reempregos críticos segundo Peter Tscherkassky, Jean-Luc Godard, Andrei Ujică e Marylène Negro
Authors: Brenez Nicole 
Published: April 2022

A história das artes (literatura, arquitetura, música, pintura, cinema) é massivamente constituída por reempregos e contrassensos. O século XX viu se desenvolver uma cultura do reemprego de intenção crítica, seja ela de ordem analítica, polêmica ou simplesmente reflexiva. À medida que as imagens se acumularam e as práticas, suportes e modos de difusão se multiplicaram, as iniciativas analíticas e críticas também se desenvolveram.
Mentre Accade e Gia Futuro: Il Cinema di Yervant Gianikian e Angela Ricci Lucchi
Authors: Bertozzi Marco 
Published: April 2022

Mentre il documentario tradizionale utilizza le immagini quali portatrici di realtà naturali - in una probatorietà che avviluppa il pensiero critico nell’illusione della pura referenzialità – il cinema di Gianikian e Ricci Lucchi apre all’idea che le immagini possano/debbano significare “ancora”. E “altro”. Se il cinema contemporaneo diviene progressivamente un giacimento di sguardi meticci le pratiche del riciclo di Gianikian e Ricci Lucchi godono di una esemplarietà unica. In essa l’analisi storico-filologica dei materiali di partenza è momento preliminare, non mero escamotage all’atto trasformativo. Origine, dispositivo, immagine, corpo sono termini in fibrillazione, piattaforme per ri-lanci ermeneutici di un’immaginazione storiografica in cui i film dimenticati ritrovano una verità contemporanea: la nuova possibilità di significazione esce dalla dimensione archeologica e indaga, e mostra, il processo che ha portato l’immagine a perdere valore. Per poi recuperarlo, facendo deflagrare nuove significazioni.
Atrial Electrical Remodeling in Mice With Cardiac‐Specific Overexpression of Angiotensin II Type 1 Receptor
Authors: Demers Julie , Ton Anh‐Tuan , Huynh François , Thibault Simon , Ducharme Anique , Paradis Pierre , Nemer Mona , Fiset Céline 
Published: April 2022

Background
Elevated angiotensin II levels are thought to play an important role in atrial electrical and structural remodeling associated with atrial fibrillation. However, the mechanisms by which this remodeling occurs are still unclear. Accordingly, we explored the effects of angiotensin II on atrial remodeling using transgenic mice overexpressing angiotensin II type 1 receptor (AT1R) specifically in cardiomyocytes.

Methods and Results

Voltage‐clamp techniques, surface ECG, programmed electrical stimulations along with quantitative polymerase chain reaction, Western blot, and Picrosirius red staining were used to compare the atrial phenotype of AT1R mice and their controls at 50 days and 6 months. Atrial cell capacitance and fibrosis were increased only in AT1R mice at 6 months, indicating the presence of structural remodeling. Ca
2+
(
I
CaL
) and K
+
currents were not altered by AT1R overexpression (AT1R at 50 days). However,
I
CaL
density and Ca
V
1.2 messenger RNA expression were reduced by structural remodeling (AT1R at 6 months). Conversely, Na
+
current (
I
Na
) was reduced (−65%) by AT1R overexpression (AT1R at 50 days) and the presence of structural remodeling (AT1R at 6 months) yields no further effect. The reduced
I
Na
density was not explained by lower Na
V
1.5 expression but was rather associated with an increase in sarcolemmal protein kinase C alpha expression in the atria, suggesting that chronic AT1R activation reduced
I
Na
through protein kinase C alpha activation. Furthermore, connexin 40 expression was reduced in AT1R mice at 50 days and 6 months. These changes were associated with delayed atrial conduction time, as evidenced by prolonged P‐wave duration.

Conclusions

Chronic AT1R activation leads to slower atrial conduction caused by reduced
I
Na
density and connexin 40 expression.
Epidemiology and prevalence of somatic symptom disorder at the primary care level in Muscat, Oman: A cross-sectional study
Authors: Alalawi Nouf M. , AL Salmani Asma A. , Aljabri Maha K. , Azmi Imran S. , Aljardani Mohamed M. , Al Mandhari Suaad S. , AL Kindi Yusra S. , Al Omrani Noor H. 
Published: April 2022

Objectives Somatic symptom disorder (SSD) is a diagnostic classification to describe the occurrence of physical symptoms without organic cause. This study aimed to identify prevalence rates and associated characteristics of SSD among adults in primary care settings. Methods This cross-sectional study took place between July 2020 and March 2021 and included a random selection of 3383 Omani adults attending 12 primary healthcare centres in Muscat Governorate. Screening was conducted using an Arabic version of the Somatic Symptom Scale-8 (SSS-8). Results A total of 2000 adults participated in the study (response rate: 67.3%), of which most were female (71.7%) and under 50 years old (86.2%). Based on their SSS-8 scores, 602 participants (17.8%) had SSD, resulting in an overall prevalence estimate of 30.1% (95% confidence interval: 28.13–32.15). Significant associations were observed between SSD and age ( p = 0.002), gender ( p < 0.001), marital status ( p = 0.030) and chronic comorbidities ( p = 0.001). In addition, adjusted odds ratio estimates revealed SSD to be significantly associated with gender ( p < 0.001), education level ( p < 0.001) and chronic comorbidities ( p = 0.001). Conclusion The estimated prevalence of SSD in primary care settings is high compared to reports from elsewhere in the Gulf region. There is an urgent need to enhance the diagnosis of SSD at the primary care level in order to reduce healthcare service overutilisation and patient dissatisfaction. Moreover, healthcare practitioners should be aware of the effect of age, gender, educational status and chronic comorbidities on somatic symptoms.
Factors associated with viral suppression among cisgender women living with human immunodeficiency virus in the United States: An integrative review
Authors: Labisi Titilola O , Podany Anthony T , Fadul Nada A , Coleman Jason D , King Keyonna M 
Published: April 2022

Introduction: Women account for 23% of new human immunodeficiency virus diagnoses in the United States, yet remain understudied. Adherence to antiretroviral therapy and consequent viral suppression are keys to preventing human immunodeficiency virus transmission, reducing risk of drug resistance, and improving health outcomes. Objectives: This review identified and synthesized peer-reviewed studies in the United States describing factors associated with viral suppression among cisgender women living with human immunodeficiency virus. Methods: We searched five databases: Cumulative Index to Nursing and Allied Health (CINAHL), PubMed, Embase, Scopus, and PsycINFO, and reported the findings using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Eligible studies included: (1) peer-reviewed English-language articles published since 2010; (2) includes only cisgender women; (3) participants were at least 18 years of age; (4) reported metrics on viral loads; and (5) conducted in the United States. Results: Fourteen studies in total were reviewed. Eight studies had adult women living with human immunodeficiency virus, four recruited only pregnant women, and two included only racial minority women. The most commonly reported factors negatively associated with viral suppression were substance use ( n = 4), followed by availability of health insurance, financial constraint, complexity of human immunodeficiency virus treatment regimen ( n = 3), and intimate partner violence ( n = 2). Other factors were depression, race, and age. In addition, all four studies that included only pregnant women reported early human immunodeficiency virus care engagement as a significant predictor of low viral loads pre- and post-partum. Conclusion: Substance use, financial constraint, lack of health insurance, human immunodeficiency virus treatment regimen type, intimate partner violence, and late human immunodeficiency virus care pre–post pregnancy were the most common factors negatively associated with viral suppression. There is a paucity of data on viral suppression factors related to transgender and rural populations. More human immunodeficiency virus research is needed to explore factors associated with human immunodeficiency virus treatment outcomes in transgender women and cisgender women in rural U.S. regions.
Asking different questions: highly radiogenic lead, mixing and recycling of metal and social status in the Chinese Bronze Age
Authors: Liu Ruiliang , Pollard A. Mark 
Published: April 2022

AbstractThe provenance of raw materials and finished objects is one of the most intriguing problems in archaeology. It is significant for the discussion of inter-regional cultural communication. Many of the methods used to determine provenance employed by archaeologists are shared with geologists or geochemists, among which the use of lead isotopes is probably one of the best-known. However, geologists and archaeologists do not always ask the same questions. Because of many and various human choices, it is not always possible to apply geological methods directly to archaeological objects. Specifically, the potential existence of mixing and recycling of metals challenges all the provenance studies of metal objects. In this paper, using Bronze Age China as an example, we suggest that by using geochemical techniques such as lead isotopic analysis and trace-element analysis of bronzes, but by asking slightly different questions, one can throw new light on the way in which important resources were managed by consumers of different social status within early dynastic China.
Resistance to mogamulizumab is associated with loss of CCR4 in cutaneous T-cell lymphoma
Authors: Beygi Sara , Duran George E. , Fernandez-Pol Sebastian , Rook Alain H. , Kim Youn H. , Khodadoust Michael S. 
Published: April 2022

Abstract
Mogamulizumab is a humanized anti–CC chemokine receptor 4 (CCR4) antibody approved for the treatment of mycosis fungoides and Sézary syndrome. Despite almost universal expression of CCR4 in these diseases, most patients eventually develop resistance to mogamulizumab. We tested whether resistance to mogamulizumab is associated with loss of CCR4 expression. We identified 17 patients with mycosis fungoides or Sézary syndrome who either were intrinsically resistant or acquired resistance to mogamulizumab. Low expression of CCR4 by immunohistochemistry or flow cytometry was found in 65% of patients. Novel emergent CCR4 mutations targeting the N-terminal and transmembrane domains were found in 3 patients after disease progression. Emerging CCR4 copy number loss was detected in 2 patients with CCR4 mutations. Acquisition of CCR4 genomic alterations corresponded with loss of CCR4 antigen expression. We also report on outcomes of 3 cutaneous T-cell lymphoma (CTCL) patients with gain-of-function CCR4 mutations treated with mogamulizumab. Our study indicates that resistance to mogamulizumab in CTCL frequently involves loss of CCR4 expression and emergence of CCR4 genomic alterations. This finding has implications for management and monitoring of CTCL patients on mogamulizumab and development of future CCR4-directed therapies.
Possibility of using the tips obtained from the “Uradome” of moso bamboo (Phyllostachys pubescens) as a food source
Authors: Furusawa Yuka , Kofujita Hisayoshi , Ashitani Tatsuya 
Published: April 2022

AbstractIn the cultivation of bamboo shoots in snow-covered areas, uradome is known to prevent snow damage. Although tips can be obtained by uradome, these are currently considered unutilized. Like bamboo shoots, uradome has the potential to be a source of food. Therefore, to explore the possibility of using uradome tips as food, we evaluated their egumi and umami taste, investigated the free amino acid content, and compared these parameters with those of bamboo shoots. The results showed that the egumi taste of uradome tips was weaker than that of bamboo shoots. The umami taste at first taste was weaker than that of bamboo shoots, while the umami and richness that remained after swallowing was stronger than that of bamboo shoots. The presence of a total of 18 free amino acids was evaluated in the uradome tips and bamboo shoots, and 17 free amino acids were detected in the samples, with cystine being the exception. Eleven of these free amino acids were found to be more abundant in the uradome tips. In addition, eight of the nine essential amino acids (excluding tryptophan) were found in the uradome tips and were in approximately the same amounts as in the bamboo shoots. Furthermore, leucine, a commonly known branched-chain amino acid, was present only in the uradome tips. Overall, the results suggest that uradome tips could be used as a food source.
Effects of wearing surgical masks on fraction of inspired oxygen in spontaneously breathing patients: improving safety for frontline healthcare professionals under pandemic situations
Authors: Minoguchi Kazuhiro , Isii Akira , Nakamura Toshiki , Sato Hitoshi , Abe Takeru , Kawakami Hiromasa , Nakamura Kyota , Goto Takahisa 
Published: April 2022

Abstract
Background
During pandemic situations, many guidelines recommend that surgical masks be worn by both healthcare professionals and infected patients in healthcare settings. The purpose of this study was to clarify the levels and changes of oxygen concentration over time while oxygen was administered over a surgical mask.

Methods
Patients scheduled to undergo general anesthesia (n = 99) were enrolled in this study. First, patients were administered oxygen at 6 L/min via an oxygen mask over a surgical mask for 5 min. The patients removed the surgical mask and then took a 3-min break; thereafter, the same amount of oxygen was administered for another 5 min via the oxygen mask. We measured the fraction of inspired oxygen (FiO2), the end-tidal CO2 (EtCO2), and respiratory frequency every minute for 5 min, both while administering oxygen with and without a surgical mask. The FiO2 was measured at the beginning of inspiration and the EtCO2 was measured at the end of expiration.

Results
The FiO2 at 5 min was significantly lower when breathing with a surgical mask than that without it (mean difference: 0.08 [95% CI: 0.067–0.10]; p <  0.001). In contrast, the EtCO2 at 5 min was significantly higher when breathing with a surgical mask than that without it (mean difference: 11.9 mmHg [95% CI: 10.9–12.9]; p <  0.001).

Conclusion
The FiO2 was lower when oxygen was administered over surgical masks than when patients did not wear surgical masks. Oxygen flow may need to be adjusted in moderately ill patients requiring oxygen administration.
Use of ultrasound guided single shot costotransverse block (intertransverse process) in breast cancer surgery: a prospective, randomized, assessor blinded, controlled clinical trial
Authors: Aygun Hakan , Kiziloglu Ilker , Ozturk Nilgun Kavrut , Ocal Haydar , Inal Abdullah , Kutlucan Leyla , Gonullu Edip , Tulgar Serkan 
Published: April 2022

Abstract
Background
Ultrasound guided costotransverse block (CTB) is a relatively new “peri-paravertebral” block that has been described recently. It has been previously reported that CTB, administered with a single high-volume injection, provides effective analgesia in breast conserving surgery. In this study we evaluated the effect of CTB when used in breast cancer surgery.

Methods
Seventy patients due to undergo breast cancer surgery were included in this blinded, prospective, randomized, efficiency study. Patients were randomized into two equal groups (CTB group and control group) using the closed envelope technique. All patients underwent general anesthesia. In addition to standard analgesia methods, patients in group CTB also received CTB block while the remaining (control group) did not. Numeric rating (pain) scores and opioid consumption was compared between the two groups.

Results
Opioid consumption in all time frames and pain scores at 1st and 3rd hours only were found to be significantly lower in Group CTB when compared to the control group.

Conclusions
Ultrasound guided CTB improves analgesia quality in breast cancer surgery.

Trial registration
Clinicaltrials Registration ID: NCT04197206, Registration Date: 13/12/2019.
Diagnostic performance of quantitative coronary artery disease assessment using computed tomography in patients with aortic stenosis undergoing transcatheter aortic-valve implantation
Authors: Malebranche Daniel , Hoffner Maximilian K. M. , Huber Adrian T. , Cicovic Aleksandar , Spano Giancarlo , Bernhard Benedikt , Bartkowiak Joanna , Okuno Taishi , Lanz Jonas , Räber Lorenz , Praz Fabien , Stortecky Stefan , Windecker Stephan , Pilgrim Thomas , Gräni Christoph 
Published: April 2022

Abstract
Background
Computed tomography angiography (CTA) is a cornerstone in the pre- transcatheter aortic valve replacement (TAVI) assessment. We evaluated the diagnostic performance of CTA and coronary artery calcium score (CACS) for CAD evaluation compared to invasive coronary angiography in a cohort of TAVI patients.

Methods
In consecutive TAVI patients without prior coronary revascularization and device implants, CAD was assessment by quantitative analysis in CTA. (a) Patients with non-evaluable segments were classified as obstructive CAD. (b) In patients with non-evaluable segments a CACS cut-off of 100 was applied for obstructive CAD. The reference standard was quantitative invasive coronary angiography (QCA, i.e. ≥ 50% stenosis).

Results
100 consecutive patients were retrospectively included, age was 82.3 ± 6.5 years and 30% of patients had CAD. In 16% of the patients, adequate visualization of the entire coronary tree (all 16 segments) was possible with CTA, while 84% had at least one segment which was not evaluable for CAD analysis due to impaired image quality. On a per-patient analysis, where patients with low image quality were classified as CAD, CTA showed a sensitivity of 100% (95% CI 88.4–100.0), specificity of 11.4% (95% CI 5.1–21.3), PPV of 32.6% (95% CI 30.8–34.5), NPV of 100% and diagnostic accuracy of 38% (95% CI 28.5–48.3) for obstructive CAD. When applying a combined approach of CTA (in patients with good image quality) and CACS (in patients with low image quality), the sensitivity and NPV remained at 100% and obstructive CAD could be ruled out in 20% of the TAVI patients, versus 8% using CTA alone.

Conclusion
In routinely acquired pre-TAVI CTA, the image quality was insufficient in a high proportion of patients for the assessment of the entire coronary artery tree. However, when adding CACS in patients with low image quality to quantitative CTA assessment in patients with good image quality, obstructive CAD could be ruled-out in 1/5 of the patients and may therefore constitute a strategy to streamline pre-procedural workup, and reduce risk, radiation and costs in selected TAVI patients without prior coronary revascularization or device implants.
Estimation and inference for the mediation effect in a time-varying mediation model
Authors: Cai Xizhen , Coffman Donna L. , Piper Megan E. , Li Runze 
Published: April 2022

AbstractBackgroundTraditional mediation analysis typically examines the relations among an intervention, a time-invariant mediator, and a time-invariant outcome variable. Although there may be a total effect of the intervention on the outcome, there is a need to understand the process by which the intervention affects the outcome (i.e., the indirect effect through the mediator). This indirect effect is frequently assumed to be time-invariant. With improvements in data collection technology, it is possible to obtain repeated assessments over time resulting in intensive longitudinal data. This calls for an extension of traditional mediation analysis to incorporate time-varying variables as well as time-varying effects.MethodsWe focus on estimation and inference for the time-varying mediation model, which allows mediation effects to vary as a function of time. We propose a two-step approach to estimate the time-varying mediation effect. Moreover, we use a simulation-based approach to derive the corresponding point-wise confidence band for the time-varying mediation effect.ResultsSimulation studies show that the proposed procedures perform well when comparing the confidence band and the true underlying model. We further apply the proposed model and the statistical inference procedure to data collected from a smoking cessation study.ConclusionsWe present a model for estimating time-varying mediation effects that allows both time-varying outcomes and mediators. Simulation-based inference is also proposed and implemented in a user-friendly R package.