bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of urinary catheter on resistance patterns and clinical outcomes on complicated urinary tract infection
Authors: Moreno Carlos Ernesto Lombo , Velandia Oscar Mauricio Muñoz , Sánchez Cindy Alejandra Bonilla , Diaz Juan Sebastián Montealegre , Herazo Javier Ricardo Garzón 
Published: August 2022

Abstract
Introduction and hypothesis
Complicated urinary tract infection (cUTI) is highly prevalent and costly for health systems. The impact of the indwelling urinary catheter on etiologic agents and clinical outcomes has been poorly studied in Latin America.

Methods
Cross-sectional study including patients with cUTI, with positive urine culture, treated at Hospital Universitario San Ignacio, Bogotá (Colombia) between 2017 and 2020. Clinical and microbiologic characteristics, treatments and outcomes are explored, comparing those with and without indwelling urinary catheter.

Results
Seven hundred thirty-five patients with non-catheter-associated cUTI (NC-cUTI) and 165 with catheter-associated cUTI (CAUTI) were included. CAUTI group had a higher proportion of recurrent UTI (18% vs 33.3%, p < 0.001), ICU requirement (2.7% vs 8.5%, p < 0.001), longer hospital stay (6 vs 10 days, p < 0.001) and > 30 days unplanned readmission rate (5.8% vs 10.3%, p < 0.001). In the same group, we found a higher frequency of Pseudomonas spp (2.6% vs 9.4%, p < 0.001), Enterococcus spp. (2.4% vs 3.3%, p = 0.016), Serratia marcescens (0.6% vs 3.3%, p < 0.001) and Citrobacter freundii (0.5% vs 5.7%, p < 0.001). It implied a higher number of patients treated with fourth-generation cephalosporins (1.4% vs 4.8%, p = 0.004), ertapenem (32.9% vs 41.8%, p = 0.027) and carbapenems associated with a second antibiotic (1.9% vs 8.5%, p < 0.001).

Conclusions
Patients with CAUTI have a higher frequency of resistant germs, require greater use of resources and have worse clinical outcomes than patients who do not require such devices. Measures should be strengthened to minimize its use, in both the hospital and outpatient setting.
Contextual and own-age effects in age perception
Authors: Pilz Karin S. , Lou Hao 
Published: August 2022

AbstractOur judgement of certain facial characteristics such as emotion, attractiveness or age, is affected by context. Faces that are flanked by younger faces, for example, are perceived as being younger, whereas faces flanked by older faces are perceived as being older. Here, we investigated whether contextual effects in age perception are moderated by own age effects. On each trial, a target face was presented on the screen, which was flanked by two faces. Flanker faces were either identical to the target face, were 10 years younger or 10 years older than the target face. We asked 40 older (64–69 years) and 43 younger adults (24–29) to estimate the age of the target face. Our results replicated previous studies and showed that context affects age estimation of faces flanked by target faces of different ages. These context effects were more pronounced for younger compared to older flankers but present across both tested age groups. An own-age advantage was observed for older adults for unflanked faces who had larger estimation errors for younger faces compared to older faces and younger adults. Flanker effects, however, were not moderated by own-age effects. It is likely that the increased effect of younger flankers is due to mechanisms related to perceptual averaging.
Patterns of biogeographic and regional life-history trait variation in four large-bodied tropical wrasses
Authors: Lowe J. R. , Russ G. R. , Bucol A. A. , Abesamis R. A. , Stockwell B. L. , Choat J. H. 
Published: August 2022

AbstractEctotherms display substantial demographic variation across latitudinal gradients of temperature. Higher temperatures are often associated with smaller size, rapid initial growth rates, and early maturation, generally described as the Temperature-Size Rule (TSR). The longevity of most ectotherms also declines at warmer, lower latitudes. However, these patterns may be modified by increases in food resources that can flow on to continuous growth and large adult size. The present study estimates age-based demographic parameters of large-bodied tropical wrasses (Hemigymnus melapterus, H. fasciatus, Cheilinus fasciatus, and Oxycheilinus digramma) collected from Philippine fish markets (9–11°N) and sampled from Palm (18.53–18.70°S) and Whitsunday (20.05–20.21°S) reefs on the Great Barrier Reef, Australia (GBR). Differences in longevity, initial growth rates, and the age at sexual maturation at a biogeographic scale, between the Philippines and GBR, conformed to predictions of the TSR. However, Philippine specimens exhibited greater relative body condition and sustained periods of growth beyond sexual maturity resulting in larger adult size than GBR samples. Size-structure data from Philippine marine reserves and fished sites indicated that these differences were not confounded by fishery-dependent sampling. Moreover, latitudinal length–weight relationships could not be explained by lower densities of the focal wrasses in the Philippines or by relative gonad size. Less pronounced patterns of demographic variation that differed across species were evident at a regional scale, among Palm and Whitsunday reefs. Patterns of demographic variation between the Philippines and GBR strongly suggest that differences in food resource levels will be important in explaining the observed geographic variation.
From dyads to collectives: a review of honeybee signalling
Authors: Hasenjager Matthew J. , Franks Victoria R. , Leadbeater Ellouise 
Published: August 2022

AbstractThe societies of honeybees (Apis spp.) are microcosms of divided labour where the fitness interests of individuals are so closely aligned that, in some contexts, the colony behaves as an entity in itself. Self-organization at this extraordinary level requires sophisticated communication networks, so it is not surprising that the celebrated waggle dance, by which bees share information about locations outside the hive, evolved here. Yet bees within the colony respond to several other lesser-known signalling systems, including the tremble dance, the stop signal and the shaking signal, whose roles in coordinating worker behaviour are not yet fully understood. Here, we firstly bring together the large but disparate historical body of work that has investigated the “meaning” of such signals for individual bees, before going on to discuss how network-based approaches can show how such signals function as a complex system to control the collective foraging effort of these remarkable social insect societies.
Maximizing sexual signal transmission: use of multiple display sites by male houbara bustards
Authors: Alonso Juan C. , Abril-Colón Inmaculada , Palacín Carlos , Ucero Alberto , Álvarez-Martínez José M. 
Published: August 2022

Abstract
A good location of song or call posts and visual display sites of males is crucial for territory defence and mate attraction. These sites are typically located at prominent positions to ensure an efficient, long-distance sexual advertisement. If the purpose of display sites is to maximize visibility, a suitable strategy would be to use multiple display sites rather than just one site. We investigated this in the ground-displaying houbara bustard by using two recent technological advances that enabled us collecting high precision data, GSM/GPRS loggers provided with accelerometer and very high-resolution digital elevation models of the terrain. We found that 12 out of 20 marked males used two or three display sites instead of just one as previously assumed in this species. The most used display site had the largest viewshed and use of both alternative sites decreased in proportion to their decreasing viewsheds. The number of display sites was apparently determined by two factors. First, it was correlated with display intensity, suggesting that using multiple display sites may be a mechanism to increase sexual signal transmission in males that are dominant or in better condition. Second, supplementary display sites were not used when the principal display site already provided an excellent view of the surroundings, e.g. when it was located on a hilltop. These results confirmed that the function of secondary display sites is to supplement the viewshed provided by the principal display site, and so maximize sexual signal transmission.

Significance statement
Performing sexual display from just a single place is often not enough to reach all possible mates or competitors, so using multiple posts may be crucial for an effective sexual signal transmission. This is particularly important when the display is visual, and topographical barriers or vegetation may block the male’s line of view. Using last generation GSM/GPRS loggers equipped with accelerometers and very high-resolution digital elevation models of the terrain, we show how houbara bustard males, who perform a costly running display on the ground, have developed a complex display pattern that involves the use of various nearby display sites. These display sites are used in proportion to their visibilities, which shows that this multiple display site system has evolved to maximize the aggregated visual field of males and so increase their visibility to females and neighbour males.
A statistical description method of global sub-grid topography for numerical models
Authors: Wang Yaqi , Wang Lanning , Feng Juan , Song Zhenya , Wu Qizhong , Cheng Huaqiong 
Published: August 2022

AbstractSlope and aspect are important topographic elements for thermodynamics and dynamics of atmospheric circulation, especially for local radiation and topographic precipitation. We propose a simple realistic statistical method based on trigonometric function transformation to calculate sub-grid slope and aspect for describing the orographic characteristics of complex areas over the globe. It is found that the transformed conditional probability density function conforms to the Gaussian distribution in most of the global areas (~ 98%), and this feature is not eliminated with the increasing of horizontal resolution. The reasonability of this method is tested over the Tibetan Plateau. The results show that the improvement ratio of surface solar radiation downward (SSRD) over the Tibetan Plateau improved significantly compared with the results from the grid average scheme, especially in autumn. The improvement of root mean square error is approximately 18.2 W/m2, and the improvement ratio reached 38.4%. The improvements of maximum and regional-averaged SSRD over the whole Tibetan Plateau were ~ 130 W/m2 and ~ 44.3 W/m2 respectively. Although we only consider the effect of sub-grid slope and aspect on solar shortwave radiation, which has a certain bias with the observation data, it is sufficient to prove the rationality of the statistical method compared with the unobstructed horizontal surfaces scheme.
Polar jet stream fluctuations in an energy balance model
Authors: Perillo Cord , Klein David , Djellouli Rabia 
Published: August 2022

AbstractWe investigate the effect of increased longwave radiative forcing (a proxy for increased greenhouse gas concentration) on the zonally averaged location of the eddy-driven jet stream in a latitude dependent, two-layer Energy Balance Model. The model includes separate terms for atmospheric and surface albedos, and takes into account reflections of shortwave radiation between the surface and atmospheric layers. We introduce the notion of a cloud factor function, which depends on temperature gradients, to simulate the eddy-driven jet. An increase in longwave radiative forcing initially results in a poleward movement of the jet stream’s mean latitude, but as the forcing increases, the location of the jet stream becomes quasi-periodic and its mean location moves equatorward.
Descriptive analysis of dietary (poly)phenol intake in the subcohort MAX from DCH-NG: “Diet, Cancer and Health—Next Generations cohort”
Authors: Lanuza Fabian , Zamora-Ros Raul , Rostgaard-Hansen Agnetha Linn , Tjønneland Anne , Landberg Rikard , Halkjær Jytte , Andres-Lacueva Cristina 
Published: August 2022

Abstract
Purpose
(Poly)phenols are bioactive compounds widely distributed in plant-based foods. Currently, limited data exist on the intake distribution of (poly)phenols across meals. This study aimed to estimate dietary intakes of all individual (poly)phenols and total intake per class and subclass by meal event, and to identify their main food sources in the subcohort MAX from the Diet, Cancer and Health—Next Generations cohort (DCH-NG).

Methods
Dietary data were collected using three web-based 24-h dietary recalls over 1 year. In total, 676 participants completed at least one recall. The dietary data were linked to Phenol-Explorer database using standardized procedures and an in-house software. We categorized foods/drinks into five options of meal events selected by the participant: 'Breakfast', 'Lunch', 'Evening', 'Snack', and 'Drink'.

Results
Adjusted total (poly)phenols mean intake by meal was the highest in the drink event (563 mg/day in men and 423 mg/day in women) and the lowest in the evening event (146 mg/day in men and 137 mg/day in women). The main overall (poly)phenol class contributor was phenolic acids (55.7–79.0%), except for evening and snack events where it was flavonoids (45.5–60%). The most consumed (poly)phenol subclasses were hydroxycinnamic acids and proanthocyanidins. Nonalcoholic beverages (coffee accounted for 66.4%), cocoa products, and cereals were the main food sources of total (poly)phenols.

Conclusion
This study provides data on the variability in the intake of classes and subclasses of (poly)phenols and their main food sources by meal event according to lifestyle data, age, and gender in a Danish population.
Transmission of cervid prions to humanized mice demonstrates the zoonotic potential of CWD
Authors: Hannaoui Samia , Zemlyankina Irina , Chang Sheng Chun , Arifin Maria Immaculata , Béringue Vincent , McKenzie Debbie , Schatzl Hermann M. , Gilch Sabine 
Published: August 2022

AbstractPrions cause infectious and fatal neurodegenerative diseases in mammals. Chronic wasting disease (CWD), a prion disease of cervids, spreads efficiently among wild and farmed animals. Potential transmission to humans of CWD is a growing concern due to its increasing prevalence. Here, we provide evidence for a zoonotic potential of CWD prions, and its probable signature using mice expressing human prion protein (PrP) as an infection model. Inoculation of these mice with deer CWD isolates resulted in atypical clinical manifestation with prion seeding activity and efficient transmissible infectivity in the brain and, remarkably, in feces, but without classical neuropathological or Western blot appearances of prion diseases. Intriguingly, the protease-resistant PrP in the brain resembled that found in a familial human prion disease and was transmissible upon second passage. Our results suggest that CWD might infect humans, although the transmission barrier is likely higher compared to zoonotic transmission of cattle prions. Notably, our data suggest a different clinical presentation, prion signature, and tissue tropism, which causes challenges for detection by current diagnostic assays. Furthermore, the presence of infectious prions in feces is concerning because if this occurs in humans, it is a source for human-to-human transmission. These findings have strong implications for public health and CWD management.
A new look into uveitis in Colombia: changes in distribution patterns and clinical characteristics over the last 25 years
Authors: Polanía Diego , Reyes-Guanes Juliana , Rojas-Carabali William , Pardo-Pizza Daniella , Barraquer-Lopez Doménico , Cifuentes-González Carlos , Neira-Segura Natalia , de-la-Torre Alejandra 
Published: August 2022

Abstract
Purpose
To describe the distribution patterns and clinical characteristics of patients diagnosed with uveitis at a specialized uveitis center in Bogotá, Colombia, from 2013 to 2021 and compare these patterns with the previously reported between 1996 and 2006.

Methods
We performed an observational descriptive cross-sectional study systematically reviewing clinical records of patients attending between 2013 and 2021. Data were analyzed and compared with previous reports.

Results
Of the 489 patients with uveitis, 310 were females (63.4%). The mean age of onset was 38.7, with a range between 1 and 83 years. Bilateral (52.8%), anterior (45.8%), non-granulomatous (90.8%), and recurrent (47.6%) were the most common types of uveitis found in our population sample. The most common cause of uveitis in this study was idiopathic, followed by toxoplasmosis and HLA-B27 + associated uveitis, which differs from the previous Colombian study where ocular toxoplasmosis was the most frequent cause. This highlights a significant shift from infectious etiologies to more immune-mediated processes as the cause of uveitis in Colombia nowadays.

Conclusion
The results of this study provide a comparison between the clinical patterns of presentation of uveitis from 1996 to 2006 and the patterns observed from 2013 to 2021, enhancing awareness about the changing dynamics of uveitis in Colombia to guide a better understanding of the diagnosis, classification, and correlation with other systemic conditions of the disease.
Multimodal tract-based MRI metrics outperform whole brain markers in determining cognitive impact of small vessel disease-related brain injury
Authors: De Luca Alberto , Kuijf Hugo , Exalto Lieza , Thiebaut de Schotten Michel , Biessels Geert-Jan ,   The Utrecht VCI Study Group, van den Berg E. , Biessels G. J. , Exalto L. G. , Frijns C. J. M. , Groeneveld O. , Heinen R. , Heringa S. M. , Kappelle L. J. , Reijmer Y. D. , Verwer J. , Vlegels N. , de Bresser J. , De Luca A. , Kuijf H. J. , Leemans A. , Koek H. L. , Hamaker M. , Faaij R. , Pleizier M. , Vriens E. 
Published: August 2022

AbstractIn cerebral small vessel disease (cSVD), whole brain MRI markers of cSVD-related brain injury explain limited variance to support individualized prediction. Here, we investigate whether considering abnormalities in brain tracts by integrating multimodal metrics from diffusion MRI (dMRI) and structural MRI (sMRI), can better capture cognitive performance in cSVD patients than established approaches based on whole brain markers. We selected 102 patients (73.7 ± 10.2 years old, 59 males) with MRI-visible SVD lesions and both sMRI and dMRI. Conventional linear models using demographics and established whole brain markers were used as benchmark of predicting individual cognitive scores. Multi-modal metrics of 73 major brain tracts were derived from dMRI and sMRI, and used together with established markers as input of a feed-forward artificial neural network (ANN) to predict individual cognitive scores. A feature selection strategy was implemented to reduce the risk of overfitting. Prediction was performed with leave-one-out cross-validation and evaluated with the R2 of the correlation between measured and predicted cognitive scores. Linear models predicted memory and processing speed with R2 = 0.26 and R2 = 0.38, respectively. With ANN, feature selection resulted in 13 tract-specific metrics and 5 whole brain markers for predicting processing speed, and 28 tract-specific metrics and 4 whole brain markers for predicting memory. Leave-one-out ANN prediction with the selected features achieved R2 = 0.49 and R2 = 0.40 for processing speed and memory, respectively. Our results show proof-of-concept that combining tract-specific multimodal MRI metrics can improve the prediction of cognitive performance in cSVD by leveraging tract-specific multi-modal metrics.
Nutrition and physical activity in cancer patients: a survey on their information sources
Authors: Boesenecker Sebastian Josef , Mathies V. , Buentzel J. , Huebner J. 
Published: August 2022

Abstract
Background
Many cancer patients suffer from problems concerning nutrition and physical activity (PA) during and after their treatment. Forwarding reliable health information could help to alleviate severe symptoms. The present study aimed to examine cancer patients’ commonly used information sources on nutrition and PA.

Methods
An anonymous questionnaire was developed and distributed to German cancer patients in different settings. In total, 90 questionnaires have been completed between October 2021 and March 2022. For analysis, descriptive statistics were used and associations between information sources and patients’ lifestyle behaviour explored utilising Spearman’s Rho, Mann–Whitney U, and Pearson’s Chi Square tests.

Results
The cancer patients received information on nutrition and PA most frequently from physicians (70.9%), family and friends (68%) and browsing the internet (61.3%). Half of the patients (51.1%) had questions concerning these topics during the time of their disease. The majority of those patients (81.8%) reported that their questions were answered. The topics were addressed primarily with outpatient oncologists (60.0%) and in rehabilitation clinics (53.3%). Just about half of the patients (55.3%) felt satisfactorily informed on nutrition and PA in their cancer disease, more so if they talked to their oncologist or family physician (Z = − 2.450, p = 0.014 and Z = − 3.425, p = 0.001 resp.).

Conclusion
Cancer patients receive information on nutrition and PA predominantly after their initial treatment. Since they might be missing significant information to alleviate severe symptoms during their treatment, the importance of nutrition and PA should be emphasised by clinicians early on in treatment.

Trial registration
Trial Registration Number (May 7, 2021): 2021-2149-Bef.
Sex-related differences of invasive therapy in patients with aneurysmal subarachnoid hemorrhage
Authors: Bögli S. Y. , Utebay D. , Smits N. , Westphal L. P. , Hirsbrunner L. , Unseld S. , Keller E. , Brandi G. 
Published: August 2022

Abstract

Background
Sex-related differences in patients with aneurysmal subarachnoid hemorrhage (aSAH) exist. More females than males are affected. Aneurysm location is associated to sex. The relationship between sex and outcome, however, is unclear. Possible differences in management might influence the occurrence of primary and secondary brain injury and thus outcome. The study compares demographics, intensity of treatment, complications, and outcome among females and males with aSAH.

Methods
All consecutive patients with aSAH admitted to the neurocritical care unit, University Hospital Zurich over a 5-year period were eligible in this retrospective study. Patients’ characteristics, comorbidities, aSAH severity, frequency of vasospasm/delayed cerebral ischemia, frequency of invasive interventions, and 3-month outcome were compared by sex. Univariate analysis was performed with the data dichotomized by sex, and outcome. Multivariate analysis for prediction of outcomes was performed.

Results
Three hundred forty-eight patients were enrolled (64% females). Women were older than men. Comorbidities, scores at admission, and treatment modality were comparable among males and females. Vasospasm and DCI occurred similarly among females and males. Interventions and frequency of intraarterial spasmolysis were comparable between sexes. In the multivariate analysis, increasing age, female sex, increasing comorbidities, WFNS and Fisher grade, and presence of delayed cerebral ischemia were predictors of unfavorable outcome when considering all patients. However, after excluding death as a possible outcome, sex did not remain a predictor of unfavorable outcome.

Conclusions
In the study population, women with aSAH might have present a worse outcome at 3 months. However, no differences by sex that might explain this difference were found in intensity of treatment and management.