bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intra-Amniotic Transplantation of Brain-Derived Neurotrophic Factor - Modified Mesenchymal Stem Cells Treatment for Rat Fetuses with Spina Bifida Aperta
Authors: Ma Wei , Wei Xiaowei , Gu Hui , Liu Dan , Luo Wenting , Cao Songying , Jia Shanshan , He Yiwen , Chen Lizhu , Bai Yuzuo , Yuan Zhengwei 
Published: March 2022

Abstract
BackgroundSpina bifida aperta (SBA) is a relatively common clinical type of neural tube defect. Although prenatal fetal surgery has been proven to be an effective treatment for SBA, the recovery of neurological function remains unsatisfactory due to neuron deficiencies. Our previous results demonstrated that intra-amniotic transplanted bone marrow mesenchymal stem cells (BMSCs) could preserve neural function through lesion-specific engraftment and regeneration. To further optimize the role of BMSCs and improve the environment of defective spinal cords so as to make it more conducive to nerve repair, the intra-amniotic transplanted BMSCs were modified with brain-derived neurotrophic factor (BDNF-BMSCs), and the therapeutic potential of BDNF-BMSCs were verified in this study.MethodsBMSCs were modified by Ad-GFP-BDNF in vitro, then transplanted into the amniotic cavity of rat fetuses with spina bifida aperta which were induced by all-trans-retinoic acid on embryonic day 15. Immunofluorescence, western blot and real-time quantitative PCR were used to detect the expression of different neuron markers and apoptosis related genes in the defective spinal cords. Lesion areas of the rat fetuses with spina bifida aperta were measured on embryonic day 20. The microenvironment changes after intra-amniotic BDNF-BMSCs transplantation were investigate by a protein array with 90 cytokines. ResultsWe found that BDNF-BMSCs sustained the characteristic of directional migration, engrafted at the SBA lesion area, increased the expression of BDNF in the defective spinal cords, alleviated the apoptosis of spinal cord cells, differentiated into neurons and skin-like cells, reduced the area of skin lesions, and improved the amniotic fluid microenvironment. Moreover, the BDNF-modified BMSCs showed a better effect than pure BMSCs on the inhibition of apoptosis and promotion of neural differentiation. ConclusionThese findings collectively indicate that intra-amniotic transplanted BDNF-BMSCs have an advantage in prompting the recovery of injured neural tissue of SBA fetuses.
Serum Potassium Trajectory During AKI and Mortality Risk
Authors: Chávez-Iñiguez Jonathan , Maggiani-Aguilera Pablo , de Quevedo Andrés Aranda-García , Granado Rolando Claure-Del , Vega-Vega Olynka , López-Giacoman Salvador R. , Chávez-Alonso Gael , Oliva-Martínez Ana E. , Díaz-Villavicencio Bladimir , Calderón-García Clementina E. , González-Barajas David , Arizaga-Nápoles Manuel , Vega-Méndez Frida M. De la , Navarro-Blackaller Guillermo , Medina-González Ramón , Ibarra-Hernández Margarita , Garcia-Garcia Guillermo 
Published: March 2022

Abstract
Background: Kidneys play a primary role in potassium homeostasis. The association between potassium (sK+) level and mortality or the need for kidney replacement therapy (KRT) during acute kidney injury (AKI) has not been adequately explored.Methods: In this prospective cohort study, AKI patients admitted to the Hospital Civil de Guadalajara were enrolled from August 2017 to June 2021 with AKI. We divided patients into 8 groups based on the serum potassium level trajectories up to ten days following hospitalization, (1) normokalemia (normoK), defined as sK+ values between 3.5 and 5.5 mEq/L; (2) corrected hyperkalemia (hyperK), sK+ > 5.5 mEq/L on hospital admission and decreased to normoK; (3) corrected hypokalemia (hypoK), sK+ < 3.5 mEq/L on hospital admission and increased to normoK; (4) fluctuating potassium, sK+ increased / decreased in and out of normoK parameters; (5) uncorrected hypoK, sK+ < 3.5 mEq/L; (6) normoK to hypoK, sK+ that were normal on hospital admission and decreased to hypoK and never went back to normal; (7) normoK to hyperK, sK+ that were normal on hospital admission and increased to hyperK and never went back to normal; (8) uncorrected hyperK, sK+ > 5.5 mEq/L. We assessed the association of serum potassium trajectories with mortality and the need for KRT (secondary objective). Results: A total of 311 AKI patients were included. The mean age was 52.6 years, and 182 (58.6%) were male. AKI stage 3 was present in 199 (63.9%). KRT started in 112 (36%) patients, and 66 (21.2%) died. After adjusting for confounders, 10-day hospital mortality was significantly higher in group 7 and 8 (OR, 1.37 and 1.63, p = <0.05, for both, respectevely), and KRT initiation was higher only in group 8 (OR 1.40, p = < 0.05) compared with group 1. Mortality in different subgroups of patients in group 8 did not change the primary results.Conclusion: In our prospective cohort, most patients with AKI had alterations in sK+. NormoK to hyperK and Uncorrected hyperK were associated with death, while only uncorrected hyperK was correlated with the need for KRT.
Expanded endoscopic endonasal transsphenoidal approach to determine morphological characteristics and clinical considerations of the cavernous sinus venous spaces
Authors: zhan guowen , Guo Shanshan , Hu Honglei , Liao Jianchun , Dang Ruishan , Yang Youxiong 
Published: March 2022

Abstract
The study aimed at investigating the morphological characteristics and interconnected regularities of the cavernous sinus (CS) venous spaces using an expanded endoscopic endonasal transsphenoidal approach.Surgical dissections were performed for 15- colored silicon–injected human head specimens. The CS venous spaces were examined for their morphological and clinical characteristics using an expanded endoscopic endonasal transsphenoidal approach. The intracavernous course of the internal carotid artery (ICA) divided the CS venous spaces into four interconnected virtual compartments: medial, anteroinferior, posterosuperior, and lateral. The CS venous spaces had peculiar morphological characteristics; the medial compartment was C-shaped while the anteroinferior compartment resembled a boat's bow. The mean distances from the medial border of the inferior horizontal segment of cavernous ICA to the mid-line of the pituitary gland (PG) were 6.07±1.61 mm (left) and 5.97±1.89 mm (right); the mean distances from the medial border of the subarachnoid segment of cavernous ICA to the mid-line of the PG were 5.77±1.16 mm (left) and 5.63±1.17 mm (right); the mean distances from the medial border of the anterior vertical segment of cavernous ICA to the mid-line of the PG were 10.27±1.74 mm (left) and 10.47±1.90 mm (right). Morphological characteristics and the knowledge of the interconnected regularities of the CS venous spaces may help surgeons accurately locate the neurovascular structure, and thus may contribute to the effective prediction of tumor invasion and extension during endoscopic CS surgery.
At equilibrium, a fixed-length bidimensional closed string, in tension, built with uniform unit mass along its perimeter, situated in a gravitational field, and separating fluids of different densities, will have a circular shape.
Authors: Cocos Mihail , Chelaru Silviu Dorian 
Published: March 2022

Abstract
In this paper we calculate the exact shape of a membrane containing a liquid and in dynamic equilibrium. The membrane can be imagined as being the crossection of a cylindrical container immersed in salt water and containing fresh water.
Exploring the Impact of Indication on Differences in Rates of Emergency Caesarean Section in Six Palestinian Hospitals: a Prospective Cohort Study
Authors: Zimmo Mohammed Walid , Laine Katariina , Hassan Sahar , Bottcher Bettina , Fosse Erik , Ali-Masri Hadil , Zimmo Kaled , Falk Ragnhild Sørum , Lieng Marit , Vikanes Ase 
Published: March 2022

Abstract
BackgroundCaesarean section rates are rising globally. No specific caesarian section rate at either country-level or hospital-level was recommended. In Palestinian government hospitals, nearly one-fourth of all births were caesarean sections, ranging from 14.5% to 35.6%. Our aim was to assess whether differences in odds for emergency caesarean section in six Palestinian government hospitals can be explained by differences in indications.MethodsData on maternal and fetal health was collected prospectively for all women scheduled for vaginal delivery during the period from 1st March 2015 to 30th November 2016 in six government hospitals in Palestine. Comparisons of proportions in sociodemographic, antenatal obstetric characteristics and indications by hospital were tested by χ2 test and differences in means by one-way ANOVA analysis. The odds for emergency caesarean section were estimated by logistic regression. The amount of explained variance was estimated by Nagelkerke R square.ResultsOut of 51,041 women, 4724 (9.3%) underwent emergency caesarean section. The prevalence of emergency caesarean section varied across hospitals; from 7.6% to 22.1% in primiparous, and from 5.8% to 14.1% among parous women. The most common indications were fetal distress and failure to progress in primiparous, and previous caesarean section in parous women. Adjusted ORs for emergency caesarean section among primiparous women ranged from 0.42 (95% CI 0.31 to 0.57) to 2.41 (95% CI 1.70 to 3.40) compared to the reference hospital, and from 0.50 (95% CI 0.40-0.63) to 2.07 (95% CI 1.61 to 2.67) among parous women. Indications explained 58% and 66% of the variation in emergency caesarean section among primiparous and parous women, respectively. ConclusionThe differences in odds for emergency caesarean section among hospitals could not be fully explained by differences in indications. Further investigations on provider related factors as well as maternal and fetal outcomes in different hospitals are necessary.
Post Traumatic Development Five Years After Cancer: Identification Of Associated Actionable Factors
Authors: Evans Catherine Karine , Saliba-Serre Bérengère , Préau Marie , Bendiane Marc-Karim , Goncalves Anthony , Signoli Michel , Bouhnik Anne Déborah 
Published: March 2022

Abstract
Background: The number of cancer survivors is growing increasingly worldwide and a growing need exists for greater knowledge into cancer survivorship. The long-term negative consequences of the disease are now better known. Cancer may also foster positive outcomes such as post-traumatic growth. Some survivors consider life after cancer as the start of a new life and put in place a coping process called post-traumatic development (PTD) measured by a scale developed by Tedeschi and Calhoun. Objective: The purpose of this article is to determine modifiable factors affecting PTD, particularly those that could integrate clinical interventions, and those that reflects patient behaviors, willing to improve their health.Methods: This study focuses on the 1,982 participants in the VICAN cohort who responded to the survey at two and five years from diagnosis. Our search for characteristics associated with moderate to high PTD was conducted using logistic regressions.Results: Factors positively associated with moderate or high PTD are, a positive perception of time spent on information, increased physical activity and healthier diet, have benefited from psychological support at the beginning of the disease.Conclusion: High PTD is strongly associated with health behavior and information. Our findings suggest that appropriate clinical and educational interventions can help foster growth after the experience of cancer. Even if we do not know what causes what, it is admitted that the interventions leading to the Adapted Physical Activities, for example, are good from all points of view.
Adaptation of the Quality-caring Model to Hospitalized School Aged Children and Their Parents
Authors: Loureiro Fernanda , Antunes Vanessa , Charepe Zaida 
Published: March 2022

Abstract
Background: the development of nursing theory improves nursing practice and consequently the health of those who receive nursing care. The aim of this article is to describe the adaptation of the quality-caring model to hospitalized school aged children and their parent.Methods: a mixed methods study in 4 phases was outlined. Study integrated a literature review (phase 1); application of surveys to hospitalized children and their parents (phase 2); delphi panel with nurses as experts (phase 3); and the the adaptation of quality-caring model (phase 4). Participants included hospitalized children (n=252), their parents (n=251) and nurses (round 1 n=47; round 2 n=42). National Data Protection Commission provided authorization for the study as well as the ethics committee from 6 health institutions where the study was applied. Results: Findings highlight the identifications of key aspects valued by children, parents, and nurses, such as: information, family involvement, play, distraction, and communication. Conclusions: The adapted model includes fundamental aspects of children hospitalization and is focused on satisfaction with care as an outcome of nursing care. Its integration in daily clinical practice if fundamental to improve quality of care and accomplish parents and children satisfaction with nursing care.
The key factors influencing patients in selecting autologous hematopoietic stem-cell transplantation as the main therapy for multiple myeloma: A population-based epidemiological study
Authors: cai zhen , yang li , He Jingsong , Yang Yang , Zhao Yi , He Donghua , Han Xiaoyan , Zheng Gaofeng , Wu Wenjun , Jiang Songfu , Lu Ying , Qian Wenbin , Ouyang Guifang , Lan Jianping , Luo Wenda , Hu Huixian , Shen Jianping , Xiao Haowen , Kuang Yuemin , Qian Shenxian , Fu Jiaping , Jiang Huifang , Yu Kang , Huang He 
Published: March 2022

Abstract
Autologous hematopoietic stem-cell transplantation (ASCT) is one of the most effective therapies for the treatment of multiple myeloma (MM). In this study, we explored factors influencing patients in selecting ASCT by analyzing population-based epidemiological data on patients’ sociodemographic and clinical variables. This multicenter study was conducted across 14 medical centers in Zhejiang Province in China. Patient survey was conducted via face-to-face interviews, telephone interviews, or online completion of questionnaire with patients’ informed consent. Patients were divided into transplantation (TR) and non-transplantation (non-TR) groups. The difference in education levels, occupational status, and annual income between the TR group and non-TR group was significant (P < 0.01). The main reasons that patients had chosen transplantation were "to delay recurrence, improve quality of life, prolong survival" and "trust the treatment provided by doctors", the main reason that patients had rejected transplantation was "worried about the physical condition”, followed by “risk of relapse”, “side effects” and “family burden”. In addition to discussing therapy with their primary physician, patients in TR group tended to obtain relevant information from other sources. Education levels, occupational status, and annual income were the main factors affecting transplantation therapy choice among patients with MM.
“Go In With An Open Mind”: Perceptions Of Exoskeleton Use During Gait Rehabilitation In An Acute Hospital Setting Following Stroke.
Authors: McDonald Caitlin , Fingleton Caitriona , Murphy Sean , Lennon Olive 
Published: March 2022

Abstract
Background: Robotic gait devices allow intensive high repetition of the gait cycle in individuals with locomotor disability, with reduced therapist effort. The addition of robotic-assisted gait training (RAGT) to usual rehabilitation post-stroke improves the likelihood of regaining independent walking, with maximum efficacy identified in the acute and subacute phases of stroke. The study explores the usability and acceptance of RAGT among persons with stroke in an acute hospital setting and examines users’ perceptions of two different modes of robotic assistance provided during rehabilitation. Methods: A mixed-methods approach comprised semi-structed interviews of end-user perspectives of RAGT in an acute hospital setting following stroke and two 10-point Likert scales rating how comfortable and how natural robotic gait felt using different assistance modes. Content analysis of qualitative data was undertaken with results synthesised by common meaning units. Quantitative data were reported using summary statistics, with Spearmann’s correlation co-efficient examining the relationship between Likert scale ratings and measures of participants’ stroke related disability. Results: Ten individuals (6 men; 4 women; mean age of 64.5. ±13 years) were recruited from an acute hospital following admission with a stroke diagnosis. Content analysis of interviews identified discussion units centring around positive aspects of the device related to how helpful the device was, negative aspects related to set-up time, weight of the device and multiple instructions during use. Initially participants identified that the device could look intimidating and that they feared falling in the device but subsequently identified the correct mindset for using the device is to trust the technology and not be afraid. Mean ratings of device comfort (7.94 ± 1.4) and how natural walking felt (7.05 ± 1.9) were favourable. Interestingly, a strong relationship was identified, whereby the higher the level of disability, the more natural participants rated walking in the device in maximal assistance mode (rho =0.62). Conclusions: This study suggests individuals in the early phases of stroke perceive RAGT to be acceptable and helpful in the main, with some associated negative aspects. The device was rated as comfortable and natural to use and those with greater disability rate the assisted walking was more natural.
Clinical Evaluation Of Protein-Sieving Coefficient In Severe Nephrotic Syndrome
Authors: Shimizu Shoichi , Saito Hiroshi , Takahashi Shori , Morohashi Tamaki , Hamada Riku , Hataya Hiroshi , Kondo Yoshiaki , Morioka Ichiro 
Published: March 2022

Abstract
Background: The pathogenesis of nephrotic syndrome is thought to be due to a decrease in protein sieving function in the glomerular capillary wall. However, no research has been conducted on the renal sieving coefficient of serum protein in nephrotic patients. We investigated the renal protein sieving coefficient in pediatric patients with severe nephrotic syndrome.Methods: Thirty pediatric patients (age: 3−20, mean: 9.3, years; 18 male and 12 female) with severe nephrotic syndrome: hypoproteinemia (TP (Total Protein) ≤ 5.0 g/dL), heavy proteinuria (UTP/Cr (Creatinine) >2 g/gCr), and a normal GFR(glomerular filtration rate) (creatinine clearance ≥ 90 mL/min), were studied. The sieving coefficient of the serum total protein (SCTP) was calculated using a simple formula: Total protein clearance/creatinine clearance (%). The correlation with a twenty-four-hour (24hr) urinary protein test corrected by body surface area (24hrUPT/BSA) was analyzed to assess the accuracy of SCTP. For reference, the correlation between 24hrUPT/BSA and UTP/Cr with SCTP was also analyzed, and the differences between these correlation coefficients were statistically examined.Results: The mean ± standard error of SCTP was 0.13 ± 0.017%. The correlation coefficients of SCTP and U-TP/Cr with 24hrUPT/BSA were 0.90 and 0.78, respectively. SCTP had a significantly stronger correlation with 24hrUPT/BSA than U-TP/Cr (p < 0.05).Conclusion: We found that only 0.13% of sieving coefficient dysfunction causes severe nephrotic syndrome. SCTP has a stronger correlation with 24hrUPT/BSA than with UTP/Cr. If nephrotic syndrome is defined as a protein-sieving dysfunction of the glomerular capillary wall, SCTP can be considered a conceptually correct indicator.
Genotyping marker density and prediction models effects in long-term breeding schemes of cross-pollinated crops
Authors: DoVale Julio Cesar , Carvalho Humberto Fanelli , Sabadin Felipe , Fritsche-Neto Roberto 
Published: March 2022

Abstract
Reductions of genotyping marker density have been extensively evaluated as potential strategies to reduce the genotyping costs of genomic selection (GS). Low-density marker panels are appealing in GS because they entail lower multicollinearity and computing time and allow more individuals to be genotyped for the same cost. However, statistical models used in GS are usually evaluated with empirical data, using "static" training sets and populations. This may be adequate for making predictions during a breeding program's initial cycles but not for the long-term. Moreover, to the best of our knowledge, no GS models consider the effect of dominance, which is particularly important for breeding outcomes in cross-pollinated crops. Hence, dominance effects are important and unexplored in GS for long-term programs involving allogamous species. To address it, we employed two approaches: analysis of empirical maize datasets and simulations of long-term breeding applying phenotypic and genomic recurrent selection (intrapopulation and reciprocal schemes). In both schemes, we simulated twenty breeding cycles and assessed the effect of marker density reduction on the population mean, the best crosses, additive variance, selective accuracy, and response to selection with models (additive, additive-dominant, general (GCA), and specific combining ability (SCA)). Our results indicate that marker reduction based on linkage disequilibrium levels provides useful predictions only within a cycle, as accuracy significantly decreases over cycles. In the long-term, without training set updating, high-marker density provides the best responses to selection. The model to be used depends on the breeding scheme: additive for intrapopulation and additive-dominant or SCA for reciprocal.
Pyridoxine Is Effective for Preventing Hand-Foot Syndrome Induced by Pegylated Liposomal Doxorubicin for Multiple Myeloma: The Results of a Randomized Study
Authors: Li Juan , Li Xiaozhe , Meilan Chen , Beihui Huang , Junru Liu , Jingli Gu , Lifen Kuang 
Published: March 2022

Abstract
Purpose: Pegylated liposomal doxorubicin (PLD) is highly effective for treating multiple myeloma (MM). Hand-foot syndrome (HFS) is a dose-limiting adverse event of PLD that may reduce a patient’s quality of life or prevent certain patients from receiving PLD. Several researchers have discovered that pyridoxine, an activated form of vitamin B6, may prevent PLD-associated HFS. We designed a prospective randomized trial to examine whether prophylactic pyridoxine might prevent the incidence or delay the occurrence of PLD-induced HFS in patients with MM.Methods: Patients who met the trial’s eligibility requirements were randomized and then administered either pyridoxine 100 mg twice daily or no pyridoxine, in both cases accompanied by their PLD-containing chemotherapeutic agent. Follow-up of patients was performed until the completion of induction therapy, the development of HFS or disease progression.Results: Between January 1, 2017, and January 1, 2019, 105 patients were randomly assigned to the pyridoxine group (n = 52) or the no pyridoxine group (n = 53). In the pyridoxine and no pyridoxine groups, HFS developed after a median of four and three chemotherapeutic cycles, respectively. There were no grade 3 incidents recorded. Overall, 13.3% of patients experienced HFS (all grades). Eleven of 53 (20.7%) patients in the pyridoxine group experienced HFS, compared to 3 of 52 (5.7%) patients in the no pyridoxine group (p=0.042); there was no difference in HFS grades (p=0.725).Conclusions: When administered concomitantly with PLD-containing chemotherapy, prophylactic pyridoxine is effective in reducing the incidence of HFS in patients with MM.Clinical Trial Registration: ChiCTR2100050294