bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ocimum sanctum [Tulsi] as a Potential Immunomodulator for the
Treatment of Ischemic Injury in the Brain
Authors: Yadav Inderjeet , Kumar Ravi , Fatima Zeeshan , Rema Velayudhan 
Published: December 2022

Abstract:
Stroke causes brain damage and is one of the main reasons for death. Most
survivors of stroke face long-term physical disabilities and cognitive dysfunctions. In
addition, they also have persistent emotional and behavioral changes. The two main
treatments that are effective are reperfusion with recombinant tissue plasminogen activator
and recanalization of penumbra using mechanical thrombectomy. However,
these treatments are suitable only for a few patients due to limitations such as susceptibility
to hemorrhage and the requirement for administering tissue plasminogen activators
within the short therapeutic window during the early hours following a stroke. The
paucity of interventions and treatments could be because of the multiple pathological
mechanisms induced in the brain by stroke. The ongoing immune response following
stroke has been attributed to the worsening brain injury. Hence, novel compounds with
immunomodulatory properties that could improve the outcome of stroke patients are
required. Natural compounds and medicinal herbs with anti-inflammatory activities and
having minimal or no adverse systemic effect could be beneficial in treating stroke.
Ocimum sanctum is a medicinal herb that can be considered an effective therapeutic
option for ischemic brain injury. Ocimum sanctum, commonly known as holy basil or
“Tulsi,” is mentioned as the “Elixir of Life” for its healing powers. Since antiquity, Tulsi
has been used in the Ayurvedic and Siddha medical systems to treat several diseases.
It possesses immuno-modulatory activity, which can alter cellular and humoral immune
responses. Tulsi can be considered a potential option as an immuno-modulator for
treating various diseases, including brain stroke.

:
In this review, we will focus on the immunomodulatory properties of Tulsi, specifically
its effect on both innate and adaptive immunity, as well as its antioxidant and antiinflammatory
properties, which could potentially be effective in treating ongoing immune
reactions following ischemic brain injury.
Overall Role of Contactins Expression in Neurodevelopmental Events and Contribution to Neurological Disorders
Authors: Bizzoca Antonella , Jirillo Emilio , Flace Paolo , Gennarini Gianfranco 
Published: December 2022

Background:Neurodegenerative disorders may depend upon a misregulation of the pathways which sustain neurodevelopmental control. In this context, this review article focuses on Friedreich ataxia (FA), a neurodegenerative disorder resulting from mutations within the gene encoding the Frataxin protein, which is involved in the control of mitochondrial function and oxidative metabolism.Objective:The specific aim of the present study concerns the FA molecular and cellular substrates, for which available transgenic mice models are proposed, including mutants undergoing misexpression of adhesive/morphoregulatory proteins, in particular belonging to the Contactin subset of the immunoglobulin supergene family.Methods:In both mutant and control mice, neurogenesis was explored by morphological/morphometric analysis through the expression of cell type-specific markers, including b-tubulin, the Contactin-1 axonal adhesive glycoprotein, as well as the Glial Fibrillary Acidic Protein (GFAP).Results:Specific consequences were found to arise from the chosen misexpression approach, consisting of a neuronal developmental delay associated with glial upregulation. Protective effects against the arising phenotype resulted from antioxidants (essentially epigallocatechin gallate (EGCG)) administration, which was demonstrated through the profiles of neuronal (b-tubulin and Contactin 1) as well as glial (GFAP) markers, in turn indicating the concomitant activation of neurodegeneration and neuro repair processes. The latter also implied activation of the Notch-1 signaling.Conclusion:Overall, this study supports the significance of changes in morphoregulatory proteins expression in the FA pathogenesis and of antioxidant administration in counteracting it, which, in turn, allows to devise potential therapeutic approaches.
In-vitro and In-vivo Neutralization Activity of Methanol Extract of
Adansonia digitata Fruit Pulp against Naja nigricollis Venom
Authors: Elijah John Oluwamayokun , Mamman Mohammed , Sani Dahiru , Yusuf Peter Ofemile , Jolayemi Kelvin Olutimilehin , Elijah Mary Oluwatomisin , Ameh Matthew Philip , Otie Dennis 
Published: December 2022

Background:
Adansonia digitata has been used as a traditional medicine to treat various
diseases including snakebite envenomation.

Objective:
In this study, the protective and ameliorative potentials of crude methanol extract of Adansonia
digitata fruit pulp against crude venom of Naja nigricollis in-vitro and in-vivo were investigated.

Method:
The dose-dependent inhibitory studies, pharmacological, histopathological and in vivo studies
were conducted using standard methods.

Result:
The mean lethal dose of the crude methanolic extract of Adansonia digitata fruit pulp in
Wistar rats was > 5,000 mg/kg, while Naja nigricollis venom was 0.89 mg/kg. The anti-lethality effective
concentration of the fruit pulp on Naja nigricollis venom was 92.52 mg/ml. Treatment significantly
(< 0.05) inhibited the activities of Naja nigricollis phospholipase A2 and dose-dependently reduced
Naja nigricollis venom-induced paw oedema at 1-4 hours post-envenomation. In-vivo, treatment
with 250 and 500 mg/kg of Adansonia digitata fruit pulp was protective against the clinical signs and
mortality. Serum acetylcholinesterase activities were maintained in the group treated with normal saline
and the ameliorative groups but decreased significantly (p < 0.05) in other groups. Brain acetylcholinesterase
was high in all the groups by day 1 but was reduced with increasing dose by day 2 in the
ameliorative groups only. Adansonia digitata fruit pulp also preserved the histoarchitecture of the
brain, heart, liver and spleen from venom-induced pathologies.

Conclusion:
Crude methanolic extract of Adansonia digitata fruit pulp possesses good protective and
ameliorative neutralization effects on Naja nigricollis venom and could be promising in the management
of snakebite envenomation.
A personagem lésbica no cinema brasileiro realizado por mulheres durante a ditadura civil-militar (1964-1985)
Authors: Cavalcante Alcilene 
Published: December 2022

Neste artigo, abordamos os termos da representação lésbica em dois longas-metragens, de ficção, realizados por mulheres no Brasil, no período de ditadura civil-militar (1964-1985). Analisamos Marcados para viver (1976), de Maria do Rosário Nascimento e Silva, e Amor maldito (1984), de Adélia Sampaio. Partimos de referenciais feministas do cinema, que reconhecem o jogo de (in)visibilidade lésbica em cinematografias, desde filmes clássicos de Hollywood, sustentando que, apesar de códigos de censura e do padrão de heterossexualidade compulsória ou de heteronormatividade, as lésbicas sempre apareceram neles, mesmo que de maneira fantasmagórica. ======
In this article, I address the terms of lesbian representation in two fictional feature films directed by women in Brazil during the period of civil-military dictatorship (1964-1985), namely Marcados para viver (1976), by Maria do Rosário Nascimento e Silva, and Amor maldito (1984), by Adélia Sampaio. Beginning with feminist references in cinema, which have recognized the play of lesbian (in)visibility in cinematographies since the classic age of Hollywood, I maintain that, despite censorship codes and the standard of compulsory heterosexuality or heteronormativity, lesbians have always been present, even if in a ghostly manner.
The Use of Passive Smartphone Data to Monitor Anxiety and Depression Among College Students in Real-World Settings: Protocol for a Systematic Review
Authors: Girousse Eva , Vuillerme Nicolas 
Published: December 2022

Background
College students are particularly at risk of depression and anxiety. These disorders have a serious impact on public health and affect patients’ daily lives. The potential for using smartphones to monitor these mental conditions, providing passively collected physiological and behavioral data, has been reported among the general population. However, research on the use of passive smartphone data to monitor anxiety and depression among specific populations of college students has never been reviewed.

Objective
This review’s objectives are (1) to provide an overview of the use of passive smartphone data to monitor depression and anxiety among college students, given their specific type of smartphone use and living setting, and (2) to evaluate the different methods used to assess those smartphone data, including their strengths and limitations.

Methods
This review will follow the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Two independent investigators will review English-language, full-text, peer-reviewed papers extracted from PubMed and Web of Science that measure passive smartphone data and levels of depression or anxiety among college students. A preliminary search was conducted in February 2022 as a proof of concept.

Results
Our preliminary search identified 115 original articles, 8 of which met our eligibility criteria. Our planned full study will include an article selection flowchart, tables, and figures representing the main information extracted on the use of passive smartphone data to monitor anxiety and depression among college students.

Conclusions
The planned review will summarize the published research on using passive smartphone data to monitor anxiety and depression among college students. The review aims to better understand whether and how passive smartphone data are associated with indicators of depression and anxiety among college students. This could be valuable in order to provide a digital solution for monitoring mental health issues in this specific population by enabling easier identification and follow-up of the patients.

Trial Registration
PROSPERO CRD42022316263; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=316263

International Registered Report Identifier (IRRID)
DERR1-10.2196/38785
Prepandemic Antivaccination Websites' COVID-19 Vaccine Behavior: Content Analysis of Archived Websites
Authors: Kaplan Samantha , von Isenburg Megan , Waldrop Lucy 
Published: December 2022

Background
The onset of the COVID-19 pandemic and the concurrent development of vaccines offered a rare and somewhat unprecedented opportunity to study antivaccination behavior as it formed over time via the use of archived versions of websites.

Objective
This study aims to assess how existing antivaccination websites modified their content to address COVID-19 vaccines and pandemic restrictions.

Methods
Using a preexisting collection of 25 antivaccination websites curated by the IvyPlus Web Collection Program prior to the pandemic and crawled every 6 months via Archive-It, we conducted a content analysis to see how these websites acknowledged or ignored COVID-19 vaccines and pandemic restrictions. Websites were assessed for financial behaviors such as having storefronts, mention of COVID-19 vaccines in general or by manufacturer name, references to personal freedom such as masking, safety concerns like side effects, and skepticism of science.

Results
The majority of websites addressed COVID-19 vaccines in a negative fashion, with more websites making appeals to personal freedom or expressing skepticism of science than questioning safety. This can potentially be attributed to the lack of available safety data about the vaccines at the time of data collection. Many of the antivaccination websites we evaluated actively sought donations and had a membership option, evidencing these websites have financial motivations and actively build a community around these issues. The content analysis also offered the opportunity to test the viability of archived websites for use in scholarly research. The archived versions of the websites had significant shortcomings, particularly in search functionality, and required supplementation with the live websites. For web archiving to be a viable source of stand-alone content for research, the technology needs to make significant improvements in its capture abilities.

Conclusions
In summary, we found antivaccination websites existing prior to the COVID-19 pandemic largely adapted their messaging to address COVID-19 vaccines with very few sites ignoring the pandemic altogether. This study also demonstrated the timely and significant need for more robust web archiving capabilities as web-based environments become more ephemeral and unstable.
The Effect of Vitamin D on Inflammation and Dyslipidemia in Type 2 Diabetes Mellitus: Protocol for a Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: MacGirlley Rizqah , Mokgalaboni Kabelo 
Published: December 2022

Background
Type 2 diabetes mellitus is a chronic disease that contributes to an increasing global burden on the health system. It has a high chance of leading to macrovascular complications and cardiovascular disease. As an inflammatory condition, it would be essential to target inflammatory pathways when developing therapeutic drugs for type 2 diabetes mellitus.

Objective
We aimed to evaluate the effect of vitamin D on markers of inflammation and lipid profile among adult patients with diabetes.

Methods
A systematic review will seek studies published on Embase, Google Scholar, PubMed, Web of Science, and Science Direct. This planned systematic review and meta-analysis will be limited to randomized controlled trials; moreover, the search will include published studies regarding the effects of vitamin D on pro-inflammatory cytokines and lipid profiles. The review will include studies published from inception until December 30, 2022. The study identification and selection will be based on the eligibility criteria by 2 independent reviewers. Additionally, a meta-analysis will only be performed if more than 2 studies are available and explore the same outcomes, and this will be analyzed using RevMan (version 5.4.1). The quality and risk of bias will be assessed following the Cochrane risk of bias tool and Jadad checklist.

Results
The process for searching literature review has already started, and this is conducted independently by 2 reviewers using a predefined eligibility and “participants, intervention, comparator, and outcome” criteria. This systematic review and meta-analysis will not require any direct involvement of patients and the public; thus, no ethical approval was required.

Conclusions
The findings obtained from the proposed study will be presented in scientific seminars, journal clubs, and conferences and published in peer-reviewed journals.

Trial Registration
International Platform of Registered Systematic Review and Meta-analysis Protocols INPLASY202260022; https://inplasy.com/?s=INPLASY202260022

International Registered Report Identifier (IRRID)
PRR1-10.2196/42193
HUBUNGAN KEMATANGAN EMOSI DENGAN FORGIVENESS PADA SISWA SMAN 1 LEMBAH GUMANTI
Authors: Fitriany Rany , Desra Hilda Hayatul , Candra Ifani 
Published: December 2022

ABSTRACTIntroduction This study aims to determine the relationship between emosional maturity and forgiveness in students of SMAN 1 Lembah Gumanti. The independent variable in this study is emosional maturity and the dependent variable is forgiveness.
Methods The measuring instrument used in this research is the emotional maturity scale and forgiveness scale. The population in this study were Students of SMAN 1 Lembah Gumanti total 0f 460 students. The sampling technique in this study used a simple random sampling technique. The sample in this study were 171 people students of SMAN 1 Lembah Gumanti.
Results The validity coefficient of emotional maturity scale obtained corrected item-total correlation values ranging from 0.327 to 0.729 while the reliability coefficient is 0.903. The results of the validity coefficient on the scale forgiveness with corrected item-total correlation values ranging from 0,324 to 0.748 while the reliability coefficient is 0.925. Based on data analysis, a correlation value of 0.452 with a significance level of 0.000 was obtained, which means the hypothesis is accepted.
Kesimpulan This shows that there is a significant positive relationship with a high level between emosional maturity and forgiveness into students SMAN 1 Lembah Gumanti. The effective contribution of the emosional maturity variable on the forgiveness variable is 20%.
Keywords: Maturity Emosional, Forgiveness, Students.
Abstrak
Pendahuluan Penelitian ini bertujuan untuk mengetahui hubungan antara kematangan emosi dengan forgiveness pada siswa SMAN 1 Lembah Gumanti. Variabel bebas dalam penelitian ini adalah kematangan emosi dan variabel terikatnya adalah forgiveness.
Metode Alat ukur yang digunakan dalam penelitian ini adalah skala kematangan emosi dan skala forgiveness. Populasi dalam penelitian ini adalah siswa di SMAN 1 Lembah Gumanti yang berjumlah 460 orang siswa. Teknik pengambilan sampel dalam penelitian ini menggunakan tehnik simple random sampling. Sampel dalam penelitian ini adalah 171 orang siswa di SMAN 1 Lembah Gumanti.
Hasil Koefisien validitas pada skala kematangan emosi dengan nilai corrected item-total correlation berkisar antara 0,327 sampai dengan 0,729 sedangkan koefisien reliabilitasnya sebesar 0,903. Hasil koefisien validitas pada skala Forgiveness dengan nilai corrected item-total correlation berkisar antara 0,324 sampai dengan 0,748, sedangkan koefisien reliabilitasnya sebesar 0,925. Berdasarkan analisis data diperoleh nilai korelasi sebesar 0,452 dengan tingkat signifikansi 0,000 yang berarti hipotesis diterima.
Kesimpulan Hal ini menunjukkan bahwa ada hubungan positif yang signifikan dengan tingkat yang tinggi antara Kematangan emosi dan forgiveness pada pada siswa SMAN 1 Lembah Gumanti. Kontribusi efektif dari variabel kematangan emosi pada variabel Forgiveness adalah sebesar 20%.
Kata kunci: Kematangan Emosi , forgiveness, Siswa.
Putusan Pengadilan sebagai Objek Penulisan Artikel Ilmiah
Authors: Shidarta Shidarta 
Published: December 2022

Specific knowledge and abilities are required for the design and technical writing of scientific papers that are the subject of judicial rulings. This document intends to provide a roadmap for academics who want to publish articles in scientific publications about the study of court decisions. This paper covers the issue’s triggering variables, which serve as criteria for why a decision is intriguing and worthy of investigation. This paper then goes on to cover in detail numerous technical components of writing systematics, starting with the backdrop and problem formulation, literature review, analysis, and conclusions and recommendations. From all these discussions, this paper emphasizes that the problem formulation (research question) is a very crucial stage in the study of decisions. This formulation must be paid an adequate background that identifies the existence of legal problems in the decision. Through this formulation, it will also be known whether the study leads to a type of research that is merely descriptive, descriptive-analytical, or analytical-prescriptive. Researchers can anticipate and overcome numerous hurdles that may arise when performing a court decision review according to the author’s explanation.
Abstrak
Desain dan teknis penulisan artikel ilmiah yang berobjekkan putusan pengadilan membutuhkan pengetahuan dan keterampilan yang cukup khas. Tulisan ini bertujuan untuk menawarkan satu panduan yang dapat diikuti oleh peneliti yang ingin menuliskan artikel kajian putusan pengadilan itu ke dalam jurnal ilmiah. Tulisan ini membahas tentang faktor-faktor pemantik isu yang menjadi kriteria mengapa suatu putusan menarik dan layak untuk diteliti. Tulisan kemudian menguraikan secara deskriptif mengenai beberapa segi teknis yang layak dicermati yang berkorelasi dengan sistematika penulisan mulai dari latar belakang dan rumusan permasalahan, tinjauan literatur, analisis, serta kesimpulan dan saran. Dari semua bahasan tersebut, tulisan ini menekankan bahwa perumusan masalah adalah tahapan yang sangat krusial di dalam kajian putusan. Rumusan ini wajib diberi latar belakang yang memadai yang mengidentifikasi adanya problematika hukum di dalam putusan tersebut. Melalui rumusan itu juga akan diketahui apakah kajian itu mengarah ke tipe penelitian yang sekadar deskriptif, deskriptif-analitis, atau analitis-preskriptif. Melalui paparan dari artikel ini, para peneliti diharapkan dapat mengantisipasi dan mengatasi berbagai kendala yang mungkin dihadapi dalam melakukan kajian putusan pengadilan.
A prospective study evaluating fluorescence guided minimally invasive paediatric solid tumour surgery using indocyanine green.
Authors: Pachl Maximilian , CV Anna Harris , S Choudhury 
Published: December 2022

Background Indocyanine green (ICG) fluoresces in the near infra-red
(NIR) spectrum. It is widely used in adult oncological surgery for
identification of tumor margins and lymph node sampling. However, its
use in the pediatric population is limited. This is the first study in
children to assess its feasibility in minimally invasive surgery (MIS)
for oncological disease Methods This was an open label, prospective,
single centre, feasibility study recruiting consecutive patients
eligible for MIS tumor resection. ICG was injected intravenously at
induction of anaesthesia and/or intra-parenchymally for patients having
tumor nephrectomy. Patient demographics, intraoperative appearances,
nodal fluorescence, post-operative histopathology, and surgeon Likert
ratings were collected. Results Seventeen patients conformed to the
inclusion criteria. Five had a Wilms tumor, 4 had lung metastases and 8
had other tumors (neuroblastoma, inflammatory myofibroblastic tumor,
ganglioneuroma, phaeochromocytoma, adrenal tumor). For those having
lymph node sampling, a median of 8(3-9) nodes were sampled. Lung
metastases were easily identifiable, and all had negative margins.
Tumors containing viable disease fluoresced and were completely
resected, whilst benign and heavily treated tumors were afluorescent.
There were no adverse events relating to ICG. Conclusion Based on this
small sample, injection of ICG during induction of anaesthesia is safe
and effective in showing tumor margins in patients who have had little
or no neoadjuvant chemotherapy as well as in metastectomy in Wilms and
osteosarcoma. Its use in renal tumor resection results in adequate nodal
sampling. Further studies are needed to confirm these preliminary
results.