bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developmental delay and late onset HBSL pathology in hypomorphic Dars1M256L mice
Authors: Klugmann Matthias , Kalotay Elizabeth , Delerue Fabien , Ittner Lars M. , Bongers Andre , Yu Josephine , Morris Margaret J. , Housley Gary D. , Fröhlich Dominik 
Published: March 2022

AbstractThe leukodystrophy Hypomyelination with Brainstem and Spinal cord involvement and Leg spasticity (HBSL) is caused by recessive mutations of the DARS1 gene, which encodes the cytoplasmic aspartyl-tRNA synthetase. HBSL is a spectrum disorder with disease onset usually during early childhood and no available treatment options. Patients display regression of previously acquired motor milestones, spasticity, ataxia, seizures, nystagmus, and intellectual disabilities. Gene-function studies in mice revealed that homozygous Dars1 deletion is embryonically lethal, suggesting that successful modelling of HBSL requires the generation of disease-causing genocopies in mice. In this study, we introduced the pathogenic DARS1M256L mutation located on exon nine of the murine Dars1 locus. Despite causing severe illness in humans, homozygous Dars1M256L mice were only mildly affected. To exacerbate HBSL symptoms, we bred Dars1M256L mice with Dars1-null ‘enhancer’ mice. The Dars1M256L/− offspring displayed increased embryonic lethality, severe developmental delay, reduced body weight and size, hydrocephalus, anophthalmia, and vacuolization of the white matter. Remarkably, the Dars1M256L/− genotype affected energy metabolism and peripheral organs more profoundly than the nervous system and resulted in reduced body fat, increased respiratory exchange ratio, reduced liver steatosis, and reduced hypocellularity of the bone marrow. In summary, homozygous Dars1M256L and compound heterozygous Dars1M256L/− mutation genotypes recapitulate some aspects of HBSL and primarily manifest in developmental delay as well as metabolic and peripheral changes. These aspects of the disease might have been overlooked in HBSL patients with severe neurological deficits but could be included in the differential diagnosis of HBSL in the future.
Detection, characterization, and analysis of land subsidence in Nairobi using InSAR
Authors: Kirui Pius , Oiro Samson , Waithaka Hunja , Odera Patroba , Riedel Björn , Gerke Markus 
Published: March 2022

AbstractNairobi, Kenya’s capital city, is one of the fastest-growing cities on the continent. The rapid expansion of human activities has resulted in the overexploitation of natural resources, such as water. In the past, Nairobi had been identified as a vulnerable area to environmental hazards, such as land subsidence. Due to the lack of a functioning deformation-monitoring system in Kenya, the subsidence in Nairobi has yet to be empirically quantified. In this paper, we report the results of the first InSAR-based spatial assessment of land subsidence in Nairobi. Our analysis indicates both localized and regionalized subsidence in several locations in the west and north west of Nairobi. The largest deforming unit in Nairobi’s western part is subsiding at approximately 62 mm/yr. Land subsidence can be attributed to groundwater overexploitation because it coincides with regions with the highest decline in groundwater levels. However, subsidence can also be attributed to consolidation associated with rapid urbanization in other areas such as east of Nairobi. This evaluation corroborates previous hydrogeological investigations which indicated that Nairobi was at risk of subsidence, contributing to flooding in some residential areas. The findings will help guide future decision-making in several agencies as well as provide an effective tool for planning mitigation measures to prevent further subsidence. A few of these include regulating borehole drilling, planning of roads and buildings, and locating groundwater observation wells. In addition, the observed significant land subsidence stresses the need for an updated geodetic reference system. Since Nairobi plays a significant role in the economy of Kenya, the effects of subsidence may be devastating and it is imperative that steps are taken to minimize their impact.
Potential of on-demand services for urban travel
Authors: Geržinič Nejc , van Oort Niels , Hoogendoorn-Lanser Sascha , Cats Oded , Hoogendoorn Serge 
Published: March 2022

AbstractOn-demand mobility services are promising to revolutionise urban travel, but preliminary studies are showing they may actually increase total vehicle miles travelled, worsening road congestion in cities. In this study, we assess the demand for on-demand mobility services in urban areas, using a stated preference survey, to understand the potential impact of introducing on-demand services on the current modal split. The survey was carried out in the Netherlands and offered respondents a choice between bike, car, public transport and on-demand services. 1,063 valid responses are analysed with a multinomial logit and a latent class choice model. By means of the latter, we uncover four distinctive groups of travellers based on the observed choice behaviour. The majority of the sample, the Sharing-ready cyclists (55%), are avid cyclists and do not see on-demand mobility as an alternative for making urban trips. Two classes, Tech-ready individuals (27%) and Flex-ready individuals (9%) would potentially use on-demand services: the former is fairly time-sensitive and would thus use on-demand service if they were sufficiently fast. The latter is highly cost-sensitive, and would therefore use the service primarily if it is cheap. The fourth class, Flex-sceptic individuals (9%) shows very limited potential for using on-demand services.
Evaporation-Driven Density Instabilities in Saturated Porous Media
Authors: Bringedal Carina , Schollenberger Theresa , Pieters G. J. M. , van Duijn C. J. , Helmig Rainer 
Published: March 2022

AbstractSoil salinization is a major cause of soil degradation and hampers plant growth. For soils saturated with saline water, the evaporation of water induces accumulation of salt near the top of the soil. The remaining liquid gets an increasingly larger density due to the accumulation of salt, giving a gravitationally unstable situation, where instabilities in the form of fingers can form. These fingers can, hence, lead to a net downward transport of salt. We here investigate the appearance of these fingers through a linear stability analysis and through numerical simulations. The linear stability analysis gives criteria for onset of instabilities for a large range of parameters. Simulations using a set of parameters give information also about the development of the fingers after onset. With this knowledge, we can predict whether and when the instabilities occur, and their effect on the salt concentration development near the top boundary.
Examination of the latent structure of the Ruminative Thoughts Style Questionnaire across countries, gender, and over time
Authors: Vidal-Arenas Verónica , Ibáñez Manuel I. , Ortet-Walker Jordi , Ortet Generós , Mezquita Laura ,   Cross-cultural Addictions Study Team, Bravo Adrian J. , Henson James M. , Pearson Matthew R. , Pilatti Angelina , Prince Mark A. , Read Jennifer P. , Roozen Hendrik G. , Ruiz Paul 
Published: March 2022

AbstractThe present work aimed to extend the evidence of the structure validity of the Ruminative Thought Style Questionnaire (RTSQ) 15-item version testing: (1) the structure of two competing models (i.e., four-factor correlated model vs a second-order factor model); (2) the measurement invariance of the final model across four countries (U.S., Spain, Argentina, and the Netherlands) and gender groups (male and female); and (3) the invariance across three assessment waves in a subsample of Spanish youths. Participants were college students (mean age = 20.87, SD = 4.47) from the U.S. (n = 1875; 67.1% of females), Spain (T1, n = 732, 63.9% females; T2, n = 370, 71.6% females: T3, n = 307, 60.6% females), Argentina (n = 368, 65.6% females) and the Netherlands (n = 295, 74.8% females). Confirmatory Factor Analyses supported both correlated factors and second-order factor structure in the whole sample. Due to similar fit indices being observed for both models, and considering the theoretical and practical advantages, we kept the second-order model to examine its invariance across groups and time. Measurement invariance analyses showed that the second-order model was invariant across countries, gender, and over time. Comparisons of the total mean score and the subfacet mean scores (i.e., Repetitive Thoughts, Counterfactual Thoughts, Problem-focused Thoughts, and Anticipatory Thoughts) reveled only small differences across country and gender groups. The present work extends the structural validity evidence of the RTSQ, and provides the first evidence concerning its longitudinal stability across time.
The application of water–energy nexus in the Middle East and North Africa (MENA) region: a structured review
Authors: Maftouh A. , El Fatni O. , Fayiah M. , Liew R. K. , Lam S. S. , Bahaj T. , Butt M. H. 
Published: March 2022

AbstractWater plays an important role in power generation, fuel manufacturing, and processing. This has been valid for several decades, but lately, primarily due to climate change, the limitations and insecurity related to water energy connections have become more prominent. The article is a quantitative review study conducted to evaluate the water–energy nexus in the Middle East and North Africa (MENA) region. Information about the review was generated from online databases by using keywords such as water–energy nexus, MENA region, Power Generation, Fuel Manufacturing, Energy-intensive, Energy Management Decisions, and Desalination Systems. Drip irrigation in Morocco played a vital role in the water–energy nexus for resource conservation and their better utilization. From the findings, it was revealed that distorted coupling with a relatively low reliance on freshwater energy systems has a high reliance on conceptual water and energy production systems. For Saudi Arabia, extraction and desalination of groundwater are projected to be up to 9% of total annual electricity use. Policymakers should consider energy implications for water-intensive food imports and possible water demand restructuring. This would lead to more coordinated water and energy management decisions. A comprehensive evaluation in some cases promotes the reuse of water and improvements in the agricultural sector rather than the development of energy-intensive and expensive desalination systems. One of the limitations for water–energy nexus in the MENA region is its unintelligible patterns for policy and decision-makers, and this quantitative review can be a major advancement in this regard. This study also highlights the use of water as an energy production source as well as the energy that is being utilized in water treatment and processing and their interrelationship. Cohesive and strategic tactics can lead technology’s research and development to reporting local issues of water and energy issues. Improving and participating models and data will better assist scholars, decision-makers, and the community. This water–energy nexus study mounts relevant challenges and areas of improvement for future research.
Insights into the pore structure characteristics of the Lower Silurian Longmaxi Formation shale in the Jiaoshiba area, Southern Sichuan Basin, China
Authors: Xiong Jian , Li Yukang , Zhou Shangwen , Liu Xiangjun , Han Hui , Liang Lixi , Zhao Jun 
Published: March 2022

AbstractIn this paper, the pore structure characteristics of shales and its controlling factors were analyzed by means of total organic carbon (TOC) analysis, X-ray diffraction (XRD) analysis, field emission scanning electron microscopy (FE-SEM) and low-pressure N2 adsorption (LPNA) analysis. Based on the grey relational analysis, the controlling factors of pore structure parameters were discussed. The results showed that the TOC contents range from 2.98 to 4.97%, the main minerals of shales are quartz and clay minerals with an average of 41.62 and 30.98%, respectively. The organic matter pores, the interparticle pores, the intraparticle pores, and the micro-fractures are the main pore types determined by the FE-SEM observation. The pore volume of shales is between 0.0637 and 0.1053 cm3/g, the specific surface area ranges from 16.44 to 37.61 m2/g, the average pore size is between 11.20 and 15.50 nm. The organic matter and the quartz have a positive influence on the specific surface area and total pore volume, whereas the clay minerals have a negative impact. The shales have a wide range of pore size, and the mesopores and macropores are the dominant contributor to the total pore volume while the mesoporous contribute the main specific surface area. The TOC contents and quartz contents have the most significant effect on the total pore volume and specific surface area, and the average pore size is mainly controlled by the quartz contents.
Triangular Ratio Metric Under Quasiconformal Mappings in Sector Domains
Authors: Rainio Oona , Vuorinen Matti 
Published: March 2022

AbstractThe hyperbolic metric and different hyperbolic type metrics are studied in open sector domains of the complex plane. Several sharp inequalities are proven for them. Our main result describes the behavior of the triangular ratio metric under quasiconformal maps from one sector onto another one.
The weight of harm: A Response to “Editor’s Note: Societal changes and expression of concern about Rekers and Lovaas’ (1974) Behavioral Treatment of Deviant Sex-Role Behaviors in a Male Child”
Authors: Johnson Austin H. 
Published: March 2022

AbstractIn 1974, Rekers and Lovaas published an article in the Journal of Applied Behavior Analysis (JABA) wherein the authors coached a 4-year-old child’s parents to ignore and physically abuse him when he engaged in behaviors that were identified by the authors as inappropriate for a child whose sex assigned at birth was male. In October 2020, a Statement of Concern regarding Rekers and Lovaas (1974) was published in JABA (SEAB & LeBlanc, 2020), which described concerns regarding the paper and then provided justification for the journal’s decision to not retract this paper. In this current response, I provide a counterpoint to the Statement of Concern, arguing that (a) the available evidence strongly suggests that the original study was unethical and misaligned with the principles of Applied Behavior Analysis (ABA), and (b) the evidence presented to support its contemporaneous ethicality is insufficient. I end with an argument that Rekers and Lovaas (1974) should be retracted and discuss the critical role of ethics and social significance for the field of ABA.
Intrasurgical Seminiferous Tubular Diameter Correlates with Total Motile Sperm Count in Azoospermia: a Prospective Cohort Study
Authors: Amer Medhat , GamalEl Din Sameh Fayek , Zeidan Ashraf , Adel Ahmed , Elsisi Islam , Fakhry Emad , Sadek Ahmed Raef 
Published: March 2022

Abstract
We aimed to find a correlation between the intraoperative diameters of the seminiferous tubules evaluated at high magnification during micro-testicular sperm extraction (micro-TESE) and total motile sperm count (TMSC) in non-obstructive azoospermic (NOA) patients. Five hundred four consecutive NOA patients were included and underwent micro-TESE. The change in the mean TMSC and different seminiferous tubular diameters was of high statistical significance (p < 0.001). It should be noted that the highest mean TMSC was reported in the dilated tubules (DTs) group followed by the other study groups 941.72 ± 196.97, 487.37 ± 443.57, and 34.54 ± 60.79, respectively. Furthermore, 21 naïve cases had dilated tubules (DTs) and 18 (85.7%) of them had shown eventful micro-TESE. Conversely, 186 naïve cases had slightly dilated tubules (SDTs), and 101 (54.3%) of them had eventful micro-TESE. Only 8 (24.25%) cases of the 33 cases had non dilated tubules (NDTs) and showed eventful micro-TESE. The frequency of intrasurgical seminiferous tubular diameter and micro-TESE outcome among the naïve cases had demonstrated a highly statistical significance (p < 0.001). Interestingly, all salvaged cases (100%) with DTs and a previous eventful TESE had shown eventful TESE in the current study. The most dilated intrasurgical seminiferous tubular diameter is associated with the highest TMSC in NOA patients including SCO cases.
Assessment of the aluminium contents of black tea and black tea infusions
Authors: Ozdemir Zarife , Zannou Oscar , Koca Ilkay 
Published: March 2022

AbstractThe aluminium (Al) can cause health problems to human being at overdose. The black tea is among the most common beverages in the world but may contain higher amount of Al. This study was conducted to determine Al content in black tea produced in Rize, Tabzon and Giresun/ Turkey and amount of Al transferred into tea infusions. Tea infusions were prepared for 15, 30, 45 and 60 min and the Al content was determined using the inductively coupled plasma optical emission spectroscopy (ICP-OES). The Al content in black teas was ranged from 8177.75 ± 1167.76 to 15,657.72 ± 1060.05 mg/kg. Al content of samples taken from Trabzon were lower than the Al contents of samples collected from Rize and Giresun. Infusion time effected significantly the amount of Al transferred into the tea infusions (p < 0.05). The Al content in black teas was significantly influenced by the production location and depended on the harvest season (p > 0.05).
Do Firm Support Increase Investments? Evidence from the Aquaculture and Fish Processing Sectors in Sweden
Authors: Blomquist Johan , Waldo Staffan 
Published: March 2022

AbstractThe European Union provides firm support to the maritime sector to reach the policy objectives in the Common Fisheries Policy. This paper analyzes to what extent the investment support to aquaculture and fish processing firms in Sweden increases firm investment activity. By doing so, the paper also quantifies the amount of investments that would have been undertaken also without support (deadweight losses, DWL). The results show that the support increases investment in aquaculture with a factor of 0.65, thus with a DWL of 35%. The corresponding number for fish processing is a DWL of 77%.
Monitoring Different Social Media Platforms to Report Unplanned School Closures Due to Wildfires in California, October and December 2017
Authors: Buchanan Brittany M. , Evans Haley I. , Chukwudebe Ngozi P. , Duncan Emily A. , Yin Jingjing , Adhikari Bishwa B. , Zhou Xiaolu , Tse Zion Tsz Ho , Chowell Gerardo , Meltzer Martin I. , Fung Isaac Chun-Hai 
Published: March 2022

Abstract

Objective:
Researchers at the Centers for Disease Control and Prevention monitor unplanned school closure (USC) reports through online systematic searches (OSS) to assist public health emergency responses. We counted the additional reports identified through social media along with OSS to improve USC monitoring.

Methods:
Facebook and Twitter data of public-school districts and private schools in counties affected by California wildfires in October and December of 2017 and January of 2018 were retrieved. We computed descriptive statistics and performed multivariable logistic regression for both OSS and social media data.

Results:
Among the 362 public-school districts in wildfire-affected counties, USCs were identified for 115 (32%) districts, of which OSS identified 104 (90%), Facebook, 59 (52%), and Twitter, 37 (32%). These data correspond to 4622 public schools, among which USCs were identified for 888 (19.2%) schools, of which OSS identified 722 (81.3%), Facebook, 496 (55.9%), and Twitter, 312 (35.1%). Among 1289 private schools, USCs were identified for 104 schools, of which OSS identified 47 (45.2%), Facebook, 67 (64.4%), and Twitter, 29 (27.9%). USC announcements identified via social media, in addition to those via OSS, were 11 public school districts, 166 public schools, and 57 private schools.

Conclusion:
Social media complements OSS as additional resources for USC monitoring during disasters.
COVID-19 and Insecurity in Northern Nigeria
Authors: Wada Yusuf Hassan , Musa Shuaibu Saidu , Musa Shingin Kovona , Musa Muhammad Kabir , Bakabe Tijjani Ibrahim , Abdullahi Abba Khalid , Ahmadi Attaullah , Lucero-Prisno Don Eliseo 
Published: March 2022

AbstractNorthern Nigeria is currently facing a twin crisis of both coronavirus disease 2019 (COVID-19) and insecurity. They have made it difficult for the people to follow government containment efforts to control the pandemic and also have impacted on the socioeconomic and health aspects of the society. We have discussed on the impact of insecurity amid COVID-19 in Northern Nigeria. It is opined that, if the insecurity in Northern Nigeria is not tackled, it will expose the region to more escalation of cases and deaths. Thus, it is recommended that proactive steps should be implemented by all stakeholders concerned to tackle insecurity, particularly the government to revive the security architecture, provide an environment for training and retraining of all security personnel and enhancing intelligence gathering to pave the way for resolving this issue.
An inventory of Norway's glaciers and ice-marginal lakes from 2018–19 Sentinel-2 data
Authors: Andreassen Liss M. , Nagy Teodor , Kjøllmoen Bjarne , Leigh Joshua R. 
Published: March 2022

AbstractWe used Sentinel-2 satellite imagery at 10 m resolution to map the extent of Norway's glaciers and ice-marginal lakes over 2018–19. We applied a standardized semi-automated band ratio method to derive glacier outlines and ice-marginal lakes. To optimise the results, we manually edited the ice-lake interfaces, debris, snow and parts of the glaciers situated under shadow. We compared our Sentinel-2 derived outlines with very high-resolution aerial orthophotos and Pléiades satellite orthoimages. Glaciers larger than 0.3 km2have area differences within 7%, whereas values are larger for smaller glaciers. The orthophotos and orthoimages provide more details and a higher mapping accuracy for individual glaciers, but require manual digitisation, have smaller spatial and temporal coverage and can have adverse snow conditions. We found a total glacier area of 2328 ± 70 km2of which the ten largest glaciers accounted for 52%. The glacier area decreased 15% since the previous inventory (Landsat data from 1999 to 2006), the reduction being largest in northern Norway (22%) compared to southern Norway (10%). We detected more than 2000 previously undetected smaller glaciers and ice patches (covering 37 km2) and 360 new ice-marginal lakes.
The dissorophoid temnospondyl Parioxys ferricolus from the early Permian (Cisuralian) of Texas
Authors: Schoch Rainer R. , Sues Hans-Dieter 
Published: March 2022

AbstractParioxys ferricolus Cope, 1878 is a long-neglected taxon of dissorophid temnospondyls from the early Permian (Cisuralian) of Texas. Reexamination of the original material and preparation of a previously undescribed specimen shed some light on the ontogeny and reveal numerous eucacopine features. P. ferricolus is characterized by: (1) a preorbital region 1.5 times as long as the posterior skull table in juveniles and twice as long in adults, (2) a parietal only two-thirds the length of the frontal, (3) interpterygoid vacuities shorter than half the skull length, (4) choanae posteriorly extended, and (5) vomer with enlarged, V-shaped median depression. P. ferricolus is found nested with Kamacops acervalis Gubin, 1980, with which it shares synapomorphies in the palate, within the dissorophid clade Eucacopinae.