bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of a New Lymph Node Ratio-Based Staging System for Ampullary Carcinoma After Curative Pancreaticoduodenectomy
Authors: Zhang Xiaojie , Sun Chongyuan , Li Zefeng , Wang Tongbo , Zhao Lulu , Niu Penghui , Guo Chunguang , Chen Yingtai , Che Xu , Zhao Dongbing 
Published: January 2022

BackgroundLymph node metastasis (LNM) is closely associated with the prognosis of ampullary carcinoma (AC). The purpose of this study is to explore the relationship between lymph node ratio (LNR) and the prognosis of patients with AC after curative pancreaticoduodenectomy and to establish a new LNR-based staging system.MethodsAC patients in the Cancer Hospital, Chinese Academy of Medical Sciences, between 1998 and 2020 were retrospectively reviewed as the training cohort; and AC patients in the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2018 were obtained as the validation cohort. Within the training group, Kaplan–Meier survival analyses and Cox proportional hazards regression were conducted to assess the prognostic value of LNR and establish a new LNR-based staging system. Then, the new staging system was compared with the 8th American Joint Committee on Cancer (AJCC) TNM staging system in both the training and validation cohorts.ResultsA total of 264 patients in the training cohort and 199 patients in the validation cohort were enrolled. Significant overall survival (OS) difference was observed between LNR-low stage and LNR-high stage in both training (p = 0.001) and validation cohorts (p &lt; 0.001). Then a new LNR-based staging system was developed. Under the new system, the number of patients in the training cohort and validation cohort of stage I, stage II, and stage III was 30 (11%) vs. 18 (9%), 190 (72%) vs. 96 (48%), and 44 (17%) vs. 85 (43%), respectively. The new staging system classified patients with respect to survival better than did the 8th AJCC TNM staging system.ConclusionsThe new LNR-based staging system had better discriminability for predicting survival in AC patients after curative pancreaticoduodenectomy. More data are needed for further validation.
Efficacy and Safety of Ertugliflozin in Type 2 Diabetes: A Systematic Review and Meta-Analysis
Authors: Liu Li , Shi Fang-Hong , Xu Hua , Wu Yue , Gu Zhi-Chun , Lin Hou-Wen 
Published: January 2022

Objective: To evaluate the efficacy and safety of ertugliflozin in patients with type 2 diabetes.Methods: MEDLINE, EMBASE, and Cochrane Library were searched (July 31, 2021) for phase II/III randomized clinical trials, which reported the efficacy and safety of ertugliflozin. Continuous variables were calculated as weighted mean difference (WMD) and associated 95% confidence intervals (CIs); dichotomous data were expressed as risk ratios (RRs) with 95% CIs.Results: Nine randomized clinical trials including 5638 type 2 diabetes patients were included. For efficacy, ertugliflozin significantly reduced HbA1c (%) (WMD −0.452%; 95% CI −0.774 to −0.129), fasting plasma glucose (FPG) (WMD −0.870 mmol/L; 95% CI −1.418 to −0.322), body weight (WMD −1.774 kg; 95% CI −2.601 to −0.946), and blood pressure levels (systolic blood pressure: WMD −2.572 mmHg; 95% CI −3.573 to −1.571 and diastolic blood pressure: WMD −1.152 mmHg; 95% CI −2.002 to −0.303) compared with placebo and other hypoglycaemic agents. Compared with placebo, ertugliflozin was superior in reducing HbA1c (%) (WMD −0.641%) and FPG (WMD −1.249 mmol/L). And compared with active agents, ertugliflozin also could decrease HbA1c by 0.215% and FPG by 0.266 mmol/L. The interactive effect between different controls was significant (Pinteraction of 0.039). For safety, similar to other sodium-glucose cotransporter type-2 inhibitors, ertugliflozin mainly increased the risk of genital mycotic infection (RR: 4.004; 95% CI 2.504–6.402). There was no significant difference in the incidence of any adverse events (AEs), AEs related to study drug, serious AEs, deaths, and discontinuations due to AEs. Results were consistent with the most primary outcomes in subgroups analysis and sensitivity analysis.Conclusion: Ertugliflozin was relatively effective and tolerated in patients with type 2 diabetes compared with placebo or other hypoglycaemic agents, except for a high risk of genital mycotic infection.Systematic Review Registration: (ClinicalTrials.gov), identifier (CRD42020206356).
Analisis Menurunnya Performa Kompresor Udara Guna Kelancaran Operasional Mesin Induk Di Kapal MT.Asike 1
Authors: Sitompul Ali Muktar , Robinson  , Chaerudin Reza 
Published: January 2022

Mesin induk adalah sebagai tenaga penggerak utama yang berfungsi untuk mengubah tenaga mekanik menjadi tenaga pendorong bagi proppeler agar kapal dapat bergerak, dimana dalam pengoperasiannya mesin induk selalu dalam kondisi berjalan secara terus menerus, Dimana sistem penggerak awal mesin induk ini menggunakan udara bertekanan tinggi, untuk menghasilkan udara bertekanan tinggi, untuk menghasilkan udara bertekanan tinggi tersebut tentunya tidak lepas dari peranan kompresor udara. Dalam hal ini penulis telah melakukan penelitian tentang kurang optimalnya performa kompresor udara utama mengakibatkan proses pengisian ke dalam air reservoir udara start terlalu lama dan dapat mempengaruhi kelancaran olah gerak. Penelitian dimulai dari tanggal 15Agustus 2018 sampai dengan tanggal 18Agustus 2019 di kapal MT. ASIKE 1. Adapun masalah yang ditemukan adalah terjadinya penumpukan karbon pada katup udara tekan sehinggakarbon-karbon yang menempel pada katup ini mengganggu kinerja dari katup dan mempengaruhi terhadap kualitas udara hisapan kedalam botol angin dan Menurunnya kualitas minyak pelumas. Hal ini dapat diatasi dengan cara mengganti minyak lumas SAE 50 sesuai ketentuan.
O Técnico de Radiologia no estabelecimento de Níveis de Referência de Dose para os procedimentos endovasculares aórticos.
Authors: Nogueira Fábio 
Published: January 2022

Introdução: Nas patologias aórticas tem-se constatado um aumento das abordagens endovasculares. Os objetivos deste trabalho visam a caracterização da intervenção da Cirurgia Vascular nas patologias aneurismáticas aórticas e a determinação do perfil radiológico das abordagens endovasculares.
Materiais e Métodos: Foram identificadas todas as cirurgias aórticas realizadas entre 1 de janeiro de 2018 e 31 de maio de 2019. A amostra foi dividida de acordo com a abordagem (convencional vs. endovascular) e os procedimentos classificados pelo critério clínico de intervenção. Para as abordagens endovasculares identificou-se a sua tipologia, o tipo de material implantado, o equipamento utilizado e os principais descritores de dose de radiação.
Resultados: Foram intervencionados 208 pacientes, 168 do género masculino e 40 do género feminino. No total realizaram-se 121 abordagens endovasculares. Destas últimas, 87 decorreram no bloco operatório central, 15 no bloco de urgência e 19 na sala de Angiografia. No bloco operatório central o percentil 75 da Dose-área produto (DAP) situou-se nos 80,3 Gy.cm2 e o Air Kerma nos 428 mGy. No bloco de urgência o valor do percentil 75 situou-se nos 70,1 Gy.cm2 para o DAP e 389 mGy para o Air Kerma incidente. Na Angiografia o percentil 75 de ambas as grandezas de dose situou-se nos 302,92 Gy.cm2 e 2436 mGy.
Conclusão: As abordagens endovasculares são menos invasivas que as convencionais, condicionam tempos de recuperação menores, curtos internamentos em cuidados intensivos e menor mortalidade a curto prazo, no entanto, carecem de avaliações a longo prazo e estão associadas a grande exposição à radiação, sendo necessário uma continua otimização dos procedimentos.
Pengaruh Literasi Zakat, Infaq, Shadaqah (ZIS), Kepercayaan, dan Brand Awareness terhadap Keputusan Menyalurkan Zakat dan Donasi Melalui Tokopedia
Authors: Febiana Niken , Tandjung Hendri , Hakiem Hilman 
Published: January 2022

This study aims to determine the effect of literacy variables on zakat, infaq and shadaqah (zis), trust and brand awareness on decisions to distribute zakat and donations. The data processing in this study uses quantitative analysis using the Structural Equation Model (SEM) analysis technique with the Partial Least Square (PLS) approach using the SmartPLS 3.0 statistical software. The instrument used to obtain data is a questionnaire using a Likert scale. In taking the sample obtained by non-probability sampling method using purposive sampling technique, the sample obtained is 95 respondents at the students of the Faculty of Islamic Religion, Ibn Khaldun University, Bogor. The results of this study indicate that the literacy variable zis has a negative and insignificant effect on the decision to distribute zakat and donations through Tokopedia. The trust variable has a positive and significant effect on the decision to distribute zakat and donations through Tokopedia. The Brand Awareness variable has a positive but not significant effect on the decision to distribute zakat and donations through Tokopedia. Variable literacy zis, trust, brand awareness simultaneously influence the decision to distribute zakat and donations by 66.4%. While the remaining 33.6% is explained by other exogenous variables outside of this study.
Keywords: Brand Awareness, Trust, Decision to Distribute Zakat and Donations, Literacy ZIS
Conteúdos da Educação física na escola: novas propostas de investigação e compreensão
Authors: Ribas João Francisco Magno 
Published: January 2022

Muitos enfoques de investigação vêm sendo discutidos atualmente na Educação Física como a ciência do moviemento humano, ciências do esporte, motricidade humana e a ciência da ação motriz. Foi justamente esta última vertente mencionada que desencadeou a discussão do presente estudo. Inicialmente, destacaremos neste texto a organização dos conhecimentos na área da Educação Física, proposta por Pierre Parlebas determinada teoria da ação motriz ou praxiologia, que busca a compreensão das ações internas das atividades físicas. Por outro lado, o conteúdo da Educação Física trabalhado em escolas sofre influência da cultura de cada localidade, região, país,... Por que o Brasil tem o futebol como principal atividade em nossa cultura esportiva e escolar? O que vem sendo praticado em outros países? A compreensão dos ambientes culturais que determinam o conteúdo da Educação Física nas escolas e de seus significados serão analisados com base na teoria da Ecologia do Desenvolvimento Humano de Urie Bronfenbrenner. Assim, o presente estudo propõe uma nova matriz para reflexão dos conteúdos da Educação Física na Escola a partir da caracterização das atividades que são desenvolvidas em aulas de Educação Física, assim como a compreensão dos ambientes que determinam os seus conteúdos.
Forecasting the flap: predictors for pediatric lower extremity trauma reconstruction
Authors: Fallah Kasra N. , Konty Logan A. , Anderson Brady J. , Cepeda Jr Alfredo , Lamaris Grigorios A. , Nguyen Phuong D. , Greives Matthew R. 
Published: January 2022

Background Predicting the need for post-traumatic reconstruction of lower extremity injuries remains a challenge. Due to the larger volume of cases in adults than in children, the majority of the medical literature has focused on adult lower extremity reconstruction. This study evaluates predictive risk factors associated with the need for free flap reconstruction in pediatric patients following lower extremity trauma.
Methods An IRB-approved retrospective chart analysis over a 5-year period (January 1, 2012 to December 31, 2017) was performed, including all pediatric patients (<18 years old) diagnosed with one or more lower extremity wounds. Patient demographics, trauma information, and operative information were reviewed. The statistical analysis consisted of univariate and multivariate regression models to identify predictor variables associated with free flap reconstruction.
Results In total, 1,821 patients were identified who fit our search criteria, of whom 41 patients (2.25%) required free flap reconstruction, 65 patients (3.57%) required local flap reconstruction, and 19 patients (1.04%) required skin graft reconstruction. We determined that older age (odds ratio [OR], 1.134; P =0.002), all-terrain vehicle accidents (OR, 6.698; P<0.001), and trauma team activation (OR, 2.443; P=0.034) were associated with the need for free flap reconstruction following lower extremity trauma in our pediatric population.
Conclusions Our study demonstrates a higher likelihood of free flap reconstruction in older pediatric patients, those involved in all-terrain vehicle accidents, and cases involving activation of the trauma team. This information can be implemented to help develop an early risk calculator that defines the need for complex lower extremity reconstruction in the pediatric population.
Incidence of fistula after primary cleft palate repair: a 25-year assessment of one surgeon’s experience
Authors: Park Min Suk , Seo Hyung Joon , Bae Yong Chan 
Published: January 2022

Background Cleft lip and cleft palate are the most frequent congenital craniofacial deformities, with an incidence of approximately 1 per 700 people. Postoperative palatal fistula is one of the most significant long-term complications. This study investigated the incidence of postoperative palatal fistula and its predictive factors based on 25 years of experience at our hospital.
Methods We retrospectively reviewed 636 consecutive palatal repairs performed between January 1996 and October 2020 by a single surgeon. Data from patients’ medical records regarding cleft palate repair were analyzed. The preoperative extent of the cleft was evaluated using the Veau classification system, and the cleft palate repair technique was chosen according to the extent of the cleft. SPSS version 25.0 was used for all statistical analyses, and exploratory univariate associations were investigated using the t-test.
Results Fistulas occurred in 20 of the 636 patients; thus, the incidence of palatal fistula was 3.1%. The most common fistula location was the hard palate (9/20, 45%), followed by the junction of the hard and soft palate (6/20, 30%) and the soft palate (5/20, 25%). The cleft palate repair technique significantly predicted the incidence of palatal fistula following cleft palate repair (P=0.042). Fistula incidence was significantly higher in patients who underwent surgery using the Furlow double-opposing Z-plasty technique (12.1%) than in cases where the Busan modification (3.0%) or two-flap technique (2.0%) was used.
Conclusions The overall incidence of palatal fistulas was 3.1% in this study. Moreover, the technique of cleft palate repair predicted fistula incidence.
2D Covalent Organic Frameworks: From Synthetic Strategies to Advanced Optical‐Electrical‐Magnetic Functionalities
Authors: Wang Congyong , Zhang Zhicheng , Zhu Yating , Yang Chenhuai , Wu Jishan , Hu Wenping 
Published: January 2022

AbstractCovalent organic frameworks (COFs), an emerging class of organic crystalline polymers with highly oriented structures and permanent porosity, can adopt 2D or 3D architectures depending on the different topological diagrams of the monomers. Notably, 2D COFs have particularly gained much attention due to the extraordinary merits of their extended in‐plane π‐conjugation and topologically ordered columnar π‐arrays. These properties together with high crystallinity, large surface area, and tunable porosity distinguish 2D COFs as an ideal candidate for the fabrication of functional materials. Herein, this review surveys the recent research advances in 2D COFs with special emphasis on the preparation of 2D COF powders, single crystals, and thin films, as well as their advanced optical, electrical, and magnetic functionalities. Some challenging issues and potential research outlook for 2D COFs are also provided for promoting their development in terms of structure, synthesis, and functionalities.
The multipotent thidiazuron: A mechanistic overview of its roles in callogenesis and other plant cultures in vitro
Authors: Ali Haroon Muhammad , Khan Tariq , Khan Mubarak Ali , Ullah Nazif 
Published: January 2022

AbstractThidiazuron (TDZ) is an active substituted phenyl urea compound that has found a significant role as a plant growth regulator. The most exciting aspect of its function is that it can mimic auxins and cytokinin but is chemically different from these two. Many theories have been put forward, and experiments performed to understand the mode of action of TDZ in callogenesis. One suggested mechanism presents that it works by inhibiting the cytokinin degrading enzymes that compete with cytokinin for an active site on the enzyme. An example is the TDZ‐induced suppressed expression of gibberellic acid (GA) biosynthesis genes encodingGA3andGA20 oxidases. This is entailed with a slightly increased expression of GA catabolism genes encodingGA20 oxidase. Similarly, one of the recommendations is that TDZ induces the expression of specific genes and transcription regulatory sequences that are either responsible directly for callus formation or in turn induce other auxins or cytokinin for callogenesis. There is no concise review available that discusses the details of TDZ‐induced callus, specifically and other in vitro cultures in general. This review is an attempt to explore all these pathways and mechanisms involved in callogenesis in plants stimulated by TDZ.
Defining professional support by counselor education faculty of color using critical race theory
Authors: Ann Shillingford M. , Ngazimbi Evadne E. , Patel Samir H. 
Published: January 2022

AbstractImplementing professional support systems that are beneficial to the professional needs of faculty of color (FOC) have been found to promote positive work environments. Using a Critical Race Theory lens, the results of this qualitative study yielded two important themes related to support for counselor educators of color (a) culturally responsive mentoring and (b) purposeful support toward tenure and promotion. Culturally relevant implications that addresses programs and systems have been provided.
Evaluating warm‐season annual forages to fill summer forage gaps in short‐season climates
Authors: Billman Eric D. , de Souza Igor A. , Smith Richard G. , Soder Kathy J. , Warren Nicholas , Brito André F. 
Published: January 2022

AbstractAnnual warm‐season forages have been used to fill productivity and nutritional gaps during summer months throughout the southeastern United States. However, their performance and nutritive value in cooler, short‐season temperate climates above 40 °N has been less well studied. This study evaluated the forage mass and nutritive value of four warm‐season annual forages {brown midrib [BMR] sudangrass [Sorghum bicolor ssp. Drummondii (L.) Moench], buckwheat (Fagopyrum esculentum Moench), Japanese millet [Echniochloa esculenta (A. Braun) H. Scholz], and teff [Eragrostis tef (Zuccagni) Trotter]} compared with a cool‐season small grain forage, oat (Avena sativa L.), and a cool‐season annual forage legume, chickling vetch (Lathyrus sativus L.). Monocultures of the six annual forage species, along with a mixture of all six species, were evaluated over 2 years in southeastern New Hampshire. Forage mass and nutritive value were assessed at weekly intervals over 3 weeks in July–August, approximately 4‐to‐5 weeks post‐germination. Across all three harvests, buckwheat, Japanese millet, and the summer mix produced greater forage mass than oat, while chickling vetch and teff produced the least. Conversely, chickling vetch had greater crude protein (CP), acid detergent fiber, and neutral detergent fiber compared with oat, while buckwheat had the lowest CP, in vitro true dry matter digestibility, and in vitro neutral detergent fiber digestibility of all the species assessed. Japanese millet produced greater forage mass while providing similar nutritive value as oat, making it a good alternative warm‐season annual forage for use under cool, short growing seasons.
BrainForge: An online data analysis platform for integrative neuroimaging acquisition, analysis, and sharing
Authors: Verner Eric , Petropoulos Helen , Baker Bradley , Bockholt Henry Jeremy , Fries Jill , Bohsali Anastasia , Raja Rajikha , Trinh Duc Hoai , Calhoun Vince 
Published: January 2022

AbstractBrainForge is a cloud‐enabled, web‐based analysis platform for neuroimaging research. This website allows users to archive data from a study and effortlessly process data on a high‐performance computing cluster. After analyses are completed, results can be quickly shared with colleagues. BrainForge solves multiple problems for researchers who want to analyze neuroimaging data, including issues related to software, reproducibility, computational resources, and data sharing. BrainForge can currently process structural, functional, diffusion, and arterial spin labeling MRI modalities, including preprocessing and group level analyses. Additional pipelines are currently being added, and the pipelines can accept the BIDS format. Analyses are conducted completely inside of Singularity containers and utilize popular software packages including Nipype, Statistical Parametric Mapping, the Group ICA of fMRI Toolbox, and FreeSurfer. BrainForge also features several interfaces for group analysis, including a fully automated adaptive ICA approach.
A harmonized country‐level dataset to support the global stocktake regarding loss and damage from climate change
Authors: Scown Murray W. , Chaffin Brian C. , Triyanti Annisa , Boyd Emily 
Published: January 2022

AbstractUnder the Paris Agreement, parties should undertake a global stocktake of progress toward meeting the goals of the agreement and tackling climate change. The first global stocktake will be undertaken in 2023, and an assessment of loss and damage from climate change is an important part of the process. Loss and damage refer to the impacts of climate change felt when mitigation and adaptation efforts are inadequate or absent. Much data, including metrics and indicators relevant for loss and damage, are held in existing global databases, but these are disparate and cannot easily be combined and compared to support the global stocktake. We combine relevant primary data sources to provide a harmonized country‐level global dataset containing relevant indicators of recorded losses and damages from climate‐related events; exposure to climate‐related events; country vulnerability and adaptation readiness; scientific studies of climate change attribution; financial support for climate adaptation; and contextual governance conditions. The indicators are standardized against country population and GDP where relevant. We describe original data sources, processing steps, and an overview of key indicators in the dataset. We also compare the assembled data to existing global risk databases; namely, the INFORM risk index and the World Risk Index. This comparison, provided in the Supporting Information, shows a large amount of redundancy among vulnerability and governance indicators, and we suggest that creators of new databases and risk indices be clear about data limitations and the gaps that specific indices attempt to fill in the global data landscape. We recommend the standard use of ISO codes in future databases of this nature, as well as clear metadata regarding how overseas territories are treated relative to their sovereign state, and information on dissolution and creation of states over time.