bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occurrence, sources, and impact mechanisms of soil microplastics and adsorbed heavy metals in the Ebinur Lake Basin, northwest China
Authors: Zhaoyong Zhang , Jieyi Guo , Pengwei Wang 
Published: May 2022

Abstract
There is a lack of research on soil microplastics in arid oases considering the rapid economic development of northwest China and Central Asia. Here, we studied the occurrence forms, pollution status, and sources of microplastics in soils, as well as the relationship between microplastics and adsorbed heavy metals in the Ebinur Lake Basin, a typical oasis in an arid area. Results showed that (1) the average microplastic content in all soil samples was 36.15 ± 3.27 mg/kg. The contents of microplastics at different sampling points ranged between 3.89 ± 1.64 and 89.25 ± 2.98 mg/kg. Overall, the proportions of various microplastic shapes diminished in the order: film (54.25%) > fiber (18.56%) > particle (15.07%) > fragment (8.66%) > foam (3.46%). (2) Among all microplastic particles, white particles accounted for the largest proportion (52.93%), followed by green (24.15%), black (12.17%), transparent (7.16%), and yellow particles (3.59%). The proportions of microplastic particle size ranges across all soil samples diminished in the order: 1000–2000 µm (40.88%) > 500–1000 µm (26.75%) > 2000–5000 µm (12.30%) > 100–500 µm (12.92%) > 0–100 µm (7.15%). FTIR analyses showed that PET, PP, PC, PE, and PS occurred in the studied soils. (3) Random forest predictions showed that industrial and agricultural production activities and the discharge of domestic plastic waste were related to soil microplastic pollution. Agricultural plastic film was the most important factor in soil pollution in the study area. (4) Seven heavy metals extracted from microplastics in soil samples showed significant positive correlations with soil pH, EC, and total salt, N, P, and K contents (p < 0.01), indicating that these soil factors could significantly affect the contents of heavy metals carried by microplastics.
Anlotinib maintenance following adjuvant chemotherapy in newly diagnosed stage III–IV patients with epithelial ovarian cancer: a retrospective study
Authors: Ding Jianghua , Leng Zhaohui 
Published: May 2022

Abstract
Background and AimsAnti-angiogenesis therapy with bevacizumab maintenance marginally improved the median progression-free survival (mPFS) of 4.9 months in patients with advanced epithelial ovarian cancer (EOC). Anlotinib, an oral small-molecular anti-angiogenic agent, has been reported to treat platinum-resistant EOC. However, little is known about anlotinib maintenance therapy in newly diagnosed EOC.MethodsThis retrospective study included 20 patients with newly diagnosed EOC from a single hospital between January 2020 and December 2021. The primary endpoints were mPFS, the overall response rate (ORR), and the disease control rate (DCR). Adverse reactions to therapy were also assessed. ResultsAmong all EOC patients, the ORR was 65% (13/20) and the DCR was 95% (19/20), while the mPFS was 14.8 months (95% confidence interval, 11.5–18.0 months). Subgroup analysis revealed a trend toward a prolonged PFS among EOC patients with a wild-type status compared to those harboring BRCA1/2 mutations (14.8 vs. 11.8 months, P = 0.3621). Seven patients (35%) required a dose reduction because of grade 3 or 4 adverse events, which were manageable and tolerable. No anlotinib-related death events were observed.ConclusionFirst-line anlotinib maintenance following adjuvant chemotherapy might be a novel therapeutic strategy, especially for BRCA wild-type EOC patients.
Towards controlling mouse through Hand Gestures: A novel and efficient approach
Authors: Joshi Hritik , waybhase Nitin , Litoriya Ratnesh , Mangal Dharmendra 
Published: May 2022

Abstract
In today’s world, we tend to see a lot of development happening in the field of Technology. Today’s technology is combined with the technique known as computer science. This paper is additionally supported little a part of AI. This paper presents a Hand gesture-based virtual mouse on our computer’s window exploitation camera & handling the complete system by simply moving your fingers. Using finger detection ways for fast camera access and easy computer program makes it additional simply accessible. The system is employed to implement a motion tracking mouse. this technique reduces the employment of any physical mouse which saves time and additionally reduces effort.
A Multivalent Vaccine for Preventing Piglet Diarrhea A New Multivalent Vaccine Candidate Targeting Fimbriae and Enterotoxin of Enterotoxigenic Escherichia coli for Preventing Newborn Piglet Diarrhea
Authors: xu chongli , Peng Kun , She Yuhan , Fu Fengyang , Shi Qinhong , Lin Yimin Lin Yimin , Xu Chongbo 
Published: May 2022

Abstract
In order to develop the K88ac-3STa-LT2 trivalent genetically engineered inactivated vaccine, the recombinant strain BL21(DE3)(pXK88ac3STaLT2) was constructed. ELISA test showed that the K88ac-3STa-LT2 fusion protein could be recognized by STa monoclonal antibody, LT2 and K88ac antibody. The test of intragastric administration in the suckling mouse confirmed that the expressed fusion protein had lost the toxicity of the natural STa enterotoxin. The results of immune experiments showed that K88ac-3STa-LT2 fusion protein could induce rabbits to produce serum antibodies, which had the effect of neutralizing the toxicity of natural STa enterotoxin. Efficacy test of the K88ac-3STa-LT2 genetically engineered inactivated vaccine showed that the immune protection rate of the newborn piglets could reach 85% on the 1st day after suckling. At the same time, it was determined that the minimum immunization doses for mice and pregnant sows were 0.2 mL and 2.5mL respectively. This study provided scientific parameters for the industrialized production of the vaccine and showed that the K88ac-3STa-LT2 trivalent genetically engineered inactivated vaccine had a broad immune spectrum for E. coli diarrhea in newborn piglets. Through this research, a new genetic engineering vaccine candidate strain was provided for more effective prevention of E. coli diarrhea in piglets.
Projected changes in atmospheric moisture transport contributions associated with climate warming
Authors: Fernández-Alvarez Jose Carlos , Pérez-Alarcón Albenis , Rahimi Stefan , NIETO RAQUEL , Gimeno Luis 
Published: May 2022

Abstract
Global warming and associated changes in atmospheric circulation patterns are expected to alter the hydrological cycle, including the intensity and position of moisture sources. This study presents predicted changes for the middle and end of the 21st century under different climate scenarios for two important extratropical moisture sources: the North Atlantic Ocean (NATL) and Mediterranean Sea (MED). By the end of the century, moisture from the NATL will increase precipitation over eastern North America in winter, western Europe in spring, and northwestern Africa during winter and summer. Moisture from the MED will increase precipitation over the southern and western portions of the Mediterranean continental area. Precipitation associated with the MED will decrease over eastern Europe, while that associated with the NATL will decrease over western Europe and Africa. Precipitation recycling on the Iberian Peninsula will increase in all seasons except winter. Climate change, as simulated by CESM2 thus modifies atmospheric moisture transport, affecting regional hydrological cycles.
Biological survival optimizer: a new nature-inspired computation technique for engineering optimization
Authors: Zhang Qingyang , He Xiangyu , Jiang Shouyong , Dong Yongquan , Song Hui 
Published: May 2022

Abstract
This study proposes a novel and lightweight bio-inspired computation technique named biological survival optimizer (BSO), which simulates the escape behavior of prey in the natural environment. This algorithm consists of two important courses, escape phase and adjustment phase. Specifically, in the escape phase, each search agent is required to updates its location using the best, the worst and a neighboring individual of the population. The adjustment phase is implemented using the simplex algorithm for search better location of the worst agent within a small region. The effectiveness of the BSO is validated on the CEC2017 benchmark problems and three classical engineering structural problems. Simulation comparison results considering both convergence and accuracy simultaneously show that BSO can present competitive performance compared with other state-of-art optimization techniques.
A Universal Incision for Robot-assisted Thoracic Surgery
Authors: Jiao Jia , Guo Jinbao , Zhao Jia , Li Xiangnan , Du Ming 
Published: May 2022

Abstract
Objective This paper aimed to design and explore the versatility of robot-assisted in thoracic surgery incision.Methods The concept of universal incision was designed and put forward. The clinical data of 342 cases of robot-assisted thoracic surgery were summarized, including gender, age, clinical diagnosis, operative method, operative time, conversion to thoracotomy, intraoperative blood loss, number of lymph node dissection, postoperative pathology and stage, postoperative hospital stay, and postoperative complications of the patients.Results The 342 cases of robot-assisted surgery contained 78 cases of pulmonary surgery (including 54 cases of pulmonary lobectomy, 18 cases of segmental pulmonary resection, 6 cases of pulmonary wedge resection), 82 cases of esophageal surgery (including 77 cases of Mckeown approach, 5 cases of esophageal leiomyoma resection), 42 cases of mediastinal tumor (including 32 cases of anterior mediastinal tumor, 10 cases of posterior mediastinal tumor). Among them, 2 cases were converted to thoracotomy (both esophageal cases), and the rest were successful with no massive intraoperative bleeding and no perioperative death.Conclusion The universal incision of robot-assisted thoracic surgery is safe and feasible, and is suitable for most cases of thoracic surgery.
Time-lapse imaging reveals kinetics of megakaryocytic- erythroid progenitor self-renewal and differentiation
Authors: Scanlon Vanessa , Thompson Evrett , Lawton Betty R. , Kochugaeva Maria , Ta Kevin , Mayday Madeline Y , Xavier-Ferrucio Juliana , Kang Elaine , Eskow Nicole , Lu Yi-Chien , Kwon Nayoung , Laumas Anisha , Cenci Matthew , Lawrence Kalyani , Barden Katie , Larsuel Shannon , Reed Fiona , Carmona Gabriela Pena , Ubbelohde Ashley , Lee June P. , Boobalan Shakthi , Oppong Yvette , Anderson Rachel , Maynard Colby , Sahirul Kaylie , Lajeune Callista , Ivathraya Varsha , Addy Tiffany , Sanchez Patricia , Holbrook Colin , Ho Andrew Tri Van , Duncan James S. , Blau Helen , Levchenko Andre , Krause Diane S. 
Published: May 2022

Abstract
Single-cell assays have enriched our understanding of hematopoiesis and, more generally, stem and progenitor cell biology. However, these single-end-point approaches provide only a static snapshot of the state of a cell. To observe and measure dynamic changes that may instruct cell fate, we developed an approach for examining hematopoietic progenitor fate specification using long-term (> 7-day) single-cell time-lapse imaging for up to 13 generations with in situ fluorescence staining of primary human hematopoietic progenitors followed by algorithm-assisted lineage tracing. We analyzed progenitor cell dynamics, including the division rate, velocity, viability, and probability of lineage commitment, at the single-cell level over time. We established and evaluated the use of a novel U2-Net based network for automated cell segmentation and applied a Markov probabilistic model to predict progenitor division outcome over each generation in culture. We demonstrated the utility of this methodological pipeline by evaluating the effects of the cytokines thrombopoietin and erythropoietin on the dynamics of self-renewal and lineage specification in primary human bipotent megakaryocytic-erythroid progenitors (MEPs). Our data support the hypothesis that thrombopoietin and erythropoietin support the viability and self-renewal of MEPs, but do not affect fate specification. Thus, single-cell tracking of time-lapse imaged colony-forming unit assays provides a robust method for assessing the dynamics of progenitor self-renewal and lineage commitment.
A novel grinding method for the flute with the complex edge by standard wheel
Authors: Wang Hongyang , Liu Xianli , Yue Caixu , Wang Shipeng , Zheng Gaojun , Zhao Kaiwang 
Published: May 2022

Abstract
The flute plays an important role in the design process for tools. The complexity of the cutting edge is increasing continuously. Thus, it is difficult to grind flute precisely and efficiently. This paper presents a practical grinding method for the flute of tools. It solves the issue that how to grind the flute with the complex edge by standard wheels. It is summarized as follows: the curve of cutting edge and core are used as the designed parameters of the flute; We propose the fundamental conditions that the wheel doesn’t interfere with designed parameters; We can find the posture and position of wheel in the curve frame easily, thus obtain wheel trajectory. Finally, using a taper end mill as an example, the results show a good agreement between the CAM data and the model data. This proves the effectiveness of this method.
Research on synchronous characteristics of hydraulically expanded overhead cylinder of Automotive Torsion beam
Authors: Yang Kefan , Wang Youmin , Fu Kexun 
Published: May 2022

Abstract
The hydraulic bulging technology of tubes can provide hollow parts with special-shaped cross-sections. Its manufacturing process can effectively improve material utilization and product accuracy, and reduce the number and cost of molds. However, The design of hydraulic bulging die, especially the design of hydraulic system, is more complicated. The synchronization of the hydraulic system and the response of the system will affect the forming quality of parts. Aiming at the research of hydraulic system design and synchronous characteristics of hydraulic expansion mold of automobile torsion beam, this paper takes a hydraulic expansion mold of automobile closed torsion beam as the research object, CATIA software is used to design the structure of torsion beam products, and then the process loading route of parts processing is determined. Auto torsion beam hydraulic pressure expansion mould structure is designed, in view of the synchronization requirements on both sides of the hydraulic cylinder, design a new automatic correction of overhead cylinder hydraulic synchronous system, AMESIM is used to get two cylinder piston rod synchronous displacement curve, the system can adjust the bidirectional shunt follow up valve to realize the automatic adjustment function is validated, synchronization system mathematical model is established, The transfer function of the closed-loop control system is pushed to, and SIMULINK is used for simulation analysis of the system, the step response curve of the system is successfully obtained, which proves that the system performance is good, and the characteristics of the synchronization system of the overhead cylinder of the hydraulic expansion mold of the torsion beam are analyzed.
Quasi-acoustic impedance matching distributed optomechanical sensor with Aluminized coating optical fiber
Authors: Dong Yongkang , Ren Yuli , Shipulin Arkady , Zhou Dengwang , Li Tianfu , Zhang Hongying , Lin Dianyang , Ba Dexin 
Published: May 2022

Abstract
The uncoated optical fiber has been extensively researched as an optomechanical sensor since it can achieve substance identification of the surrounding media by exciting and detecting transverse acoustic waves via forward stimulated Brillouin scattering (FSBS), yet within danger of being easily broken. Although polyimide-coating fibers are reported to allow transverse acoustic waves transmission to the coating for reaching the ambient while maintaining the mechanical properties of the fiber, it still suffers from the problems of humidity sensitivity and spectral instability. Here, we propose for the first time a robust distributed FSBS-based optomechanical sensor using an aluminized coating optical fiber. Benefiting from the quasi-acoustic impedance matching condition of the aluminized coating and silica core-cladding, aluminized coating optical fibers not only have stronger mechanical properties and higher transverse acoustic wave transmission efficiency but also has a higher signal-to-noise ratio, compared to the polyimide-coating fibers. The distributed measurement ability is verified by identifying air and water around the aluminized coating optical fiber with a spatial resolution of 2 m. In addition, the proposed sensor is immune to the external relative humidity changes, which is a preponderance for liquid acoustic impedance measurements.
Analysis of the drivers of ASF introduction into pig compartments in South Africa and implications for the revision of biosecurity standards
Authors: Stoffel Carla , Buholzer Patrik , Fanelli Angela , De Nardi Marco 
Published: May 2022

Abstract
Background: While African Swine Fever (ASF) virus has historically circulated in wild pigs and in Ornithodoros ticks in parts of South Africa, the virus has spread among domestic pigs throughout the country since 2019. South Africa’s compartment system has been used as a mainstay approach to protecting the swine industry in the face of ASF. However, in 2020, two compartments broke down with ASF. The objectives of this study are to investigate the drivers for ASF introduction into the compartments, to categorize compartments by risk of ASF introduction, and to make corresponding recommendations. The relevance of risk factors for ASF introduction for each compartment were investigated among veterinarians and farm managers. The analysis of risk factors weighted according to an expert elicitation were used to categorize compartments into risk levels. Results: Drivers of disease related to human behaviors and to domestic pig management are perceived by farm managers and veterinarians of the compartments to be critical for ASF introduction into compartments in South Africa. Twenty-four units were categorized as high risk, forty-seven as medium risk, and twenty-four as low risk. “Insufficient boot and clothing biosecurity by animal health personnel” was identified as a relevant risk factor in all high risk units. Other prominent risk factors were “insufficient boot and clothing biosecurity by external people,” “underreporting of suspect ASF cases,” “improper hunting/ culling of wild suids inside the compartment,” “un-tested introductions into the herd,” and “entry and contact with free-roaming pigs.” The roles of wild pigs and competent vectors are considered minimal. There is a need for revision of the compartment standards and training of compartment personnel on the standards. The major gaps identified in the standards were absence of a monitoring programme to assess biosecurity implementation and suboptimal surveillance testing and audit strategies. Conclusions: The results of our study confirm that ASF is increasingly an anthropogenic problem. Updating the compartment standards and addressing gaps in the knowledge of compartment personnel on ASF are most critical. To enhance compliance with biosecurity measures and thus control the disease, close engagement with all stakeholders linked to the compartments is needed.
Circadian rhythm and hypothalamus-related symptoms of migraine: A prospective study
Authors: Duan Qiang , Chen Chunfu 
Published: May 2022

Abstract
Background: Hypothalamic symptoms and circadian rhythm in migraine are controversial。To use WeChat as a survey tool to explore the correlation between hypothalamus-related symptoms and migraine attacks and examine the circadian cycle of migraines. Methods: This prospective study enrolled migraine patients at the Headache Specialty Clinic, Neurology Department of Shandong Provincial Hospital, from November 2018 to January 2020. Each patient was required to report the migraine attack via WeChat for 3 months. At 08:00 every day, the WeChat mass texting function was used to send an inquiry about migraines in the past 24 h. If yes, a questionnaire was issued to obtain the details. The participants were assigned to the low (LFM) (≤5 days/month) and high (HFM) (>5 days/month) frequency migraine groups. Results: 162 participants completed the study. A total of 2875 migraine attacks were recorded. The HFM group showed more attacks at night (37.8% vs. 5.7%) and before dawn (25.5% vs. 7.9%) compared with the LFM group, while the LFM group had more attacks in the morning (53.5% vs. 11.7%) (P<0.001). Generally speaking, the two groups showed a reverse attack trend. Yawning was more frequent in the prodromal phase; facial sweating, conjunctival congestion, neck stiffness, photophobia, runny nose, nasal obstruction, and emotional changes were more frequent in the headache phase; inattention and fatigue were more frequent in the postdrome phase (all P<0.001). Conclusions: HFM and LFM display different migraine attack temporal patterns. Hypothalamus-related non-headache symptoms were present in all phases of migraine attacks. The rates of non-headache symptoms were significantly different in different phases.
Depression and anxiety among children and adolescents during the COVID-19 pandemic in Europe: A systematic review protocol
Authors: LUDWIG-WALZ Helena , DANNHEIM Indra , PFADENHAUER Lisa M. , FEGERT Jörg M. , BUJARD Martin 
Published: May 2022

Abstract
Background: A growing number of studies point to a high mental health burden among children and adolescents during the COVID-19 pandemic, particularly concerning depression and anxiety. However, the study quality and effect direction are heterogeneous in the existing studies with a lacking overview for the European continent. Therefore, research gaps exist particular regarding (1) the impact of the COVID-19 pandemic on depression and anxiety among children and adolescents in European countries with (2) a methodologically high-quality summarizing review of studies. Therefore, the planned systematic review aims to close these gaps. Methods: The systematic review was registered in the Prospective Register of Systematic Reviews (PROSPERO) and the protocol was prepared in accordance to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) statement. Search strategy was peer reviewed according to the evidence-based checklist Peer Review of Electronic Search Strategies (PRESS). Systematic search was conducted in six databases (MEDLINE, EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials, Web of Science and WHO COVID-19 database). Literature screening will be conducted independent by two authors, disagreement will be solved by a third author. Risk of bias (RoB) will be assessed using the RoB instrument for non-randomized studies of exposures. Certainty of evidence will be evaluated by using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach adapted to the use of non-randomized studies. Also, subgroup analysis, sensitivity analysis, and publication bias will be performed.Discussion: This systematic review will summarize the actual overall prevalence of depression and anxiety among children and adolescents in European countries compared to a pre-pandemic baseline with an expert opinion on the clinical relevance and extrapolation of depression and anxiety in children and adolescents in the next years. In addition, it aims identifying geographic and pandemic-policy differences and designate particularly vulnerable risk groups within European children and adolescents.