bluuebunny/crossref_metadata_2025_split huggingface dataset:
ЖИТТЄВІ ЦІННОСТІ ТА ОРІЄНТАЦІЇ ЯК ЧИННИК САМОРОЗВИТКУ ПЕДАГОГА
Authors: Бакуменко Т. К. , Доля І. В. , Холостенко Ю. В. 
Published: January 2022

У статті проаналізовано проблему саморозвитку педагога в контексті його життєвих цінностей та сенсожиттєвих орієнтацій. Трансформування освітнього простору в сучасній Україні вимагає від фахівців розвитку професійно важливих якостей, формування здатності до самовдосконалення та зростання, які неможливі без усвідомлення сенсів власного життя та діяльності. Саморозвиток педагога розглядається авторами як здатність до постійного пошуку та засвоєння нових знань, набуття нових умінь та навичок, організації освітнього процесу для суб’єктів професійної діяльності, ефективне управління ресурсами та інформаційними потоками, вміння моделювати індивідуальну професійну траєкторію, оцінювати й прогнозувати результати власної діяльності. Для педагога важливим є усвідомлення сутності, значення та завдань власної педагогічної діяльності, її мети, вміння постійно співвідносити поточні педагогічні завдання із перспективами. Залежно від сенсу, який надає фахівець власній діяльності, визначаються цілі життя та розвиток внутрішніх потреб.
Проведене дослідження переконливо доводить, що педагоги з розвиненою здатністю до саморозвитку мають життєві цінності та сенсожиттєві орієнтації, які суттєво відрізняються від аналогічних утворювань у фахівців, які зупинилися у розвитку або цей процес у них дуже сповільнився. Педагоги з високим рівнем здатності до саморозвитку мають потребу в об'єктивній інформації про власну особистість, прагнуть самопізнання, самовдосконалення; мають відповідальне ставлення до обов'язків; відрізняються поблажливістю до людей та їх недоліків і вимогливістю до себе, загальною конструктивністю особистості; професійна діяльність для них є пріоритетною, також для них важливими є проблеми родини та суспільного життя. У зв’язку з цим постає актуальне питання для подальших наукових розвідок, а саме – як стимулювати процес саморозвитку педагога, які психологічні технології для цього використовувати, як оцінювати отримані результати тощо.
Andragogic strategies for English language oral communication improvement
Authors: Remache Carrillo Noemi Mercedes , Porras Pumalema Sandra Paulina , Rodríguez Durán María Eugenia , Moyota Amaguaya Patricia Pilar 
Published: January 2022

Introduction: taking into consideration that university students are young adults, another way of teaching is needed. In this context, andragogic strategies must be applied to enhance their English language learning process. Objective: this research aims to apply andragogic strategies in the context of telework for the improvement of English oral communication of first-semester students of the industrial maintenance career of the Higher Polytechnic School of Chimborazo during the academic period October 2020 - March 2021. Methodology: This study implemented a quasi-experimental, descriptive, and mixed research. To achieve the purpose of this research, two focal groups took part. 80 students from the first semester of the Industrial Maintenance participated. The students belonging the parallel A formed the control group and the students who were registered in the parallel B formed the experimental group. The groups had the same number of students. At the beginning of the semester, the students took a pre-test; after that, the results were condensed and analyzed. Due to the low scores, the researchers planned a classroom intervention that focused the use of andragogic strategies namely discussions, problem solving, simulations, projects and analysis, to improve the students’ oral communication skills. After finishing the intervention, the students took the post-test with the same characteristics. The pre-test and the post-test had the speaking part of the PET (Preliminary English Exam). Results: After gathering data, they were analyzed through a statistical software. The means of each group were compared for the pre-test and the post-test as well. In the pre-test an equal level of English oral performance was evidenced; however, in the post test, a significant difference existed. The students belonging the experimental group obtained a mean of 5.48 for the pre-test; on the contrary, they obtained 11.40 in the post-test. On the other hand, the students who belonged the control group, kept the same level of English performance. Conclusion: Andragogic strategies are suitable and helpful to be used in the higher education to improve the students’ oral communication skills; therefore, teachers must use them to contribute with their improvement.
Identification and Validation of a Novel Genomic Instability-Associated Long Non-Coding RNA Prognostic Signature in Head and Neck Squamous Cell Carcinoma
Authors: Chen Yun , Zhao Yaqiong , Lu Ruohuang , Zhao Han , Guo Yue 
Published: January 2022

Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive malignant cancers worldwide, and accurate prognostic models are urgently needed. Emerging evidence revealed that long non-coding RNAs (lncRNAs) are related to genomic instability. We sought to identify and validate a genomic instability-associated lncRNA prognostic signature to assess HNSCC patient survival outcomes.Methods: RNA-sequencing data, somatic mutation files, and patient clinical data were downloaded from The Cancer Genome Atlas database. A total of 491 patients with completely clinical files were randomly divided into training and testing sets. In the training set, genomic instability-associated lncRNAs were screened through univariate Cox regression analyses and least absolute shrinkage and selection operator regression analyses to build a genomic instability-associated lncRNA signature (GILncSig). In addition, time-dependent receiver operating characteristic (ROC) curve, Kaplan-Meier survival curve, and clinical stratification analyses were used to evaluate the signature’s reliability. Finally, in situ hybridization experiments were performed to validate GILncSig expression levels between adjacent non-tumor tissues and tumor tissues from HNSCC patients.Results: Four genomic instability-associated lncRNAs (AC023310.4, AC091729.1, LINC01564, and MIR3142HG) were selected for the prognostic signature. The model was successfully validated using the testing cohort. ROC analysis demonstrated its strong predictive ability for HNSCC prognosis. Univariate and multivariate Cox analyses revealed that the GILncSig was an independent predictor of prognosis. HNSCC patients with a low-risk score showed a substantially better prognosis than the high-risk groups. The in situ hybridization experiments using human HNSCC tissue revealed high GILncSig expression in HNSCC tissues compared with adjacent non-tumor tissues.Conclusion: We developed a novel GILncSig for prognosis prediction in HNSCC patients, and the components of that signature might be therapeutic targets for HNSCC.
A Novel Prognostic Tool for Glioma Based on Enhancer RNA-Regulated Immune Genes
Authors: Tian Wei , Chen Kegong , Yan Guangcan , Han Xinhao , Liu Yanlong , Zhang Qiuju , Liu Meina 
Published: January 2022

Background: Gliomas are the most malignant tumors of the nervous system. Even though their survival outcome is closely affected by immune-related genes (IRGs) in the tumor microenvironment (TME), the corresponding regulatory mechanism remains poorly characterized.Methods: Specific enhancer RNAs (eRNAs) can be found in tumors, where they control downstream genes. The present study aimed to identify eRNA-regulated IRGs, evaluate their influence on the TME, and use them to construct a novel prognostic model for gliomas.Results: Thirteen target genes (ADCYAP1R1, BMP2, BMPR1A, CD4, DDX17, ELN, FGF13, MAPT, PDIA2, PSMB8, PTPN6, SEMA6C, and SSTR5) were identified and integrated into a comprehensive risk signature, which distinguished two risk subclasses. Discrepancies between these subclasses were compared to explore potential mechanisms attributed to eRNA-regulated genes, including immune cell infiltration, clinicopathological features, survival outcomes, and chemotherapeutic drug sensitivity. Furthermore, the risk signature was used to construct a prognostic tool that was evaluated by calibration curve, clinical utility, Harrell’s concordance index (0.87; 95% CI: 0.84–0.90), and time-dependent receiver operator characteristic curves (AUCs: 0.93 and 0.89 at 3 and 5 years, respectively). The strong reliability and robustness of the established prognostic tool were validated in another independent cohort. Finally, potential subtypes were explored in patients with grade III tumors.Conclusion: Overall, eRNAs were associated with immune-related dysfunctions in the TME. Targeting of IRGs regulated by eRNAs could improve immunotherapeutic/therapeutic outcomes.
Kinetics of the Photoexcited States in Thin Films of Metallo-Supramolecular Polymers With Ditopic Thiophene-Bridged Terpyridine Ligands
Authors: Menšík Miroslav , Rais David , Thottappali Muhammed Arshad , Güloğlu Pinar , Toman Petr , Vohlídal Jiří , Pfleger Jiří 
Published: January 2022

Managing the excited-state decay by a supramolecular structure is a crucial issue for organic photovoltaics. We show that in thin films of metallo-supramolecular polymers made of bis(terpyridine-4′-yl)terthiophenes and Zn2+ coupling ions, the photoexcited states generated by ultrashort laser pulses at the wavelength of 440 nm decay by the bi-molecular annihilation predominantly controlled by the Förster transfer between singlet states. During this bi-molecular annihilation of singlet states, intermediate hot triplet pairs are formed, which subsequently dissociate into long-living diffusing triplet states. It explains a significant shortening of the triplet state rise time with increasing pump fluence. The diffusion coefficient of triplets showed power-law time dependence, with its exponent proportional to the pump fluence, decreasing thus the diffusivity of triplets.
Optimal Low-Density Lipoprotein Cholesterol Levels in Adults Without Diabetes Mellitus: A Nationwide Population-Based Study Including More Than 4 Million Individuals From South Korea
Authors: Huh Ji Hye , Park Sang Wook , Go Tae-Hwa , Kang Dae Ryong , Lee Sang-Hak , Kim Jang-Young 
Published: January 2022

BackgroundAlthough the strong association between low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD) is well-known, the threshold LDL-C level at which the risk of CVD begins to increase in individuals without diabetes mellitus (DM) remains unknown. We aimed to evaluate the association between incident CVD and serum LDL-C levels with or without statin use in individuals without DM.MethodsWe identified 4,182,117 individuals without previous CVD who underwent a health screening examination in 2009 and 2011 from the Korean National Health Insurance Cohort database. The primary endpoint was a composite of cardiovascular deaths, myocardial infarction (MI) cases, and ischemic stroke cases.ResultsDuring the median follow-up of 6 years, there were 51,961 CVD events that included 17,392 MI cases, 33,779 ischemic stroke cases, and 2,039 cardiovascular deaths. The LDL-C levels that were associated with an increased risk of CVD were ≥100 mg/dL in non-statin users and ≥130 mg/dL in statin users. However, even in individuals with lower LDL-C levels, all those with fasting plasma glucose (FPG) levels ≥110 mg/dL had a significantly higher risk of CVD.ConclusionsWe demonstrated that LDL-C levels ≥100 mg/dL were correlated with an increased risk of CVD in individuals without DM and a history of CVD. We found that a glucose, cholesterol interaction increased CVD risk, and modestly elevated FPG levels (110–125 mg/dL) were associated with a higher CVD risk even in individuals with well-controlled LDL-C levels.
Differential Expression of Metabolism-Related Genes in Plateau Pika (Ochotona curzoniae) at Different Altitudes on the Qinghai–Tibet Plateau
Authors: Zhu Hongjuan , Zhong Liang , Li Jing , Wang Suqin , Qu Jiapeng 
Published: January 2022

According to life history theory, animals living in extreme environments have evolved specific behavioral and physiological strategies for survival. However, the genetic mechanisms underpinning these strategies are unclear. As the highest geographical unit on Earth, the Qinghai–Tibet Plateau is characterized by an extreme environment and climate. During long-term evolutionary processes, animals that inhabit the plateau have evolved specialized morphological and physiological traits. The plateau pika (Ochotona curzoniae), one of the native small mammals that evolved on the Qinghai–Tibet Plateau, has adapted well to this cold and hypoxic environment. To explore the genetic mechanisms underlying the physiological adaptations of plateau pika to extremely cold ambient temperatures, we measured the differences in resting metabolic rate (RMR) and metabolism-related gene expression in individuals inhabiting three distinct altitudes (i.e., 3,321, 3,663, and 4,194 m). Results showed that the body mass and RMR of plateau pika at high- and medium-altitudes were significantly higher than those at the low-altitude. The expression levels of peroxisome proliferator-activated receptor α (pparα), peroxisome proliferator-activated receptor-γ coactivator-1α (pgc-1α), and the PR domain-containing 16 (PRDM16) in white (WAT) and brown (BAT) adipose tissues of plateau pika from high- and medium-altitudes were significantly higher than in pika from the low-altitude region. The enhanced expression levels of pgc-1α and pparα genes in the WAT of pika at high-altitude showed that WAT underwent “browning” and increased thermogenic properties. An increase in the expression of uncoupling protein 1 (UCP1) in the BAT of pika at high altitude indicated that BAT increased their thermogenic properties. The gene expression levels of pparα and pgc-1α in skeletal muscles were significantly higher in high-altitude pika. Simultaneously, the expression of the sarcolipin (SLN) gene in skeletal muscles significantly increased in high-altitude pika. Our results suggest that plateau pika adapted to an extremely cold environment via browning WAT, thereby activating BAT and enhancing SLN expression to increase non-shivering thermogenesis. This study demonstrates that plateau pika can increase thermogenic gene expression and energy metabolism to adapt to the extreme environments on the plateau.
Trends of the Global, Regional, and National Incidence of Measles, Vaccine Coverage, and Risk Factors in 204 Countries From 1990 to 2019
Authors: Wang Ruitong , Jing Wenzhan , Liu Min , Liu Jue 
Published: January 2022

BackgroundMeasles is a highly contagious disease that has caused global morbidity and mortality. Though great progress has been made in measles elimination, the resurgence of measles has been observed in recent years. As extant literature were mainly confined to data of local area, we conducted a systematic analysis to explore the trends of the incidence of measles, coverage rate, and the risk factors from 1990 to 2019 on global, regional, and national levels.MethodsData on cases of incidence, age standardized rate (ASR), vaccine coverage, and risk factors of measles were retrieved from the Global Burden of Disease (GBD) Study 2019 database. Estimated averaged percentage change (EAPC) of ASR was calculated to quantify the trends of measles incidence. Pearson correlation was applied to assess the association of EAPC and measles-containing vaccine coverage rate with socio-demographic index (SDI) in 2019, and the correlation between ASR and measles-containing vaccine coverage rate.ResultsGlobally, there was a significant decrease in the number (84.18%) and ASR (6.13%, 95% CI: 5.41–6.84%) of measles incidence from 1990 to 2019. More than 80% of incidence cases were attributed to children under 5 and the proportion was highest in low SDI region. Countries and territories with low ASRs are mostly clustered in North America, Southern Latin America, and Western Europe, whereas those with high ASRs are mainly clustered in Africa, East Asia, and South Asia. Lower SDI was associated with higher ASR and lower vaccine coverage rate. The more the SDI value was further away from 0.6, the smaller the absolute value did EAPC have. Child wasting accounted for the most measles-related death cases, followed by child underweight, child stunting, and vitamin A deficiency.ConclusionsMeasles eradication is feasible, but urgently demands political commitment, financial support, and public engagement. In the context of COVID-19 pandemic and the global resurgence of measles, surveillance systems and routine immunization programs should be improved, while vaccine hesitancy needs to be addressed.
Abnormal Static and Dynamic Functional Connectivity in Left and Right Temporal Lobe Epilepsy
Authors: Pang Xiaomin , Liang Xiulin , Zhao Jingyuan , Wu Peirong , Li Xinrong , Wei Wutong , Nie Liluo , Chang Weiwei , Lv Zongxia , Zheng Jinou 
Published: January 2022

ObjectiveTemporal lobe epilepsy (TLE) can be conceptualized as a network disease. However, the network characteristics in lateralization remain controversial.MethodsIn this study, resting-state functional MRI scans were acquired from 53 TLE patients [22 with left-side TLE (LTLE) and 31 with right-side TLE (RTLE)] and 37 matched healthy controls. We focused on the characteristics of static and dynamic functional connectivity, including static connectivity patterns and topological properties, as well as temporal properties of the dynamic connectivity state and the variability of the dynamic connectivity and network topological organization. Correlation analyses were conducted between abnormal static and dynamic properties and cognitive performances.ResultsThe static functional connectivity analysis presented a significantly decreased cortical-cortical connectivity pattern and increased subcortical-cortical connectivity pattern in RTLE. The global-level network in RTLE showed a significant decrease in global efficiency. The dynamic functional connectivity analysis revealed that RTLE patients exhibited aberrant connectivity states, as well as increased variability in the subcortical-cortical connectivity. The global-level network in RTLE revealed increased variance in global efficiency and local efficiency. The static or dynamic functional connectivity in LTLE did not show any significant abnormalities. The altered dynamic properties were associated with worsening cognitive performance in language and conceptual thinking by the TLE patients.ConclusionOur findings demonstrated the presence of abnormalities in the static and dynamic functional connectivity of TLE patients. RTLE patients exhibited more pronounced aberrant connectivity patterns and topological properties, which might represent a mechanism for reconfiguration of brain networks in RTLE patients. These observations extended our understanding of the pathophysiological network mechanisms of TLE.
Fibrates for the Treatment of Primary Biliary Cholangitis Unresponsive to Ursodeoxycholic Acid: An Exploratory Study
Authors: Cançado Guilherme Grossi Lopes , Couto Cláudia Alves , Guedes Laura Vilar , Braga Michelle Harriz , Terrabuio Débora Raquel Benedita , Cançado Eduardo Luiz Rachid , Ferraz Maria Lucia Gomes , Villela-Nogueira Cristiane Alves , Nardelli Mateus Jorge , Faria Luciana Costa , Oliveira Elze Maria Gomes de , Rotman Vivian , Mazo Daniel Ferraz de Campos , Borges Valéria Ferreira de Almeida e , Mendes Liliana Sampaio Costa , Codes Liana , Pessoa Mario Guimarães , Signorelli Izabelle Venturini , Levy Cynthia , Bittencourt Paulo Lisboa 
Published: January 2022

Aim: Up to 40% of patients with primary biliary cholangitis (PBC) will have a suboptimal biochemical response to ursodeoxycholic acid (UDCA), which can be improved by the addition of fibrates. This exploratory study aims to evaluate the long-term real-life biochemical response of different fibrates, including ciprofibrate, in subjects with UDCA-unresponsive PBC.Methods: The Brazilian Cholestasis Study Group multicenter database was reviewed to assess the response rates to UDCA plus fibrates in patients with UDCA-unresponsive PBC 1 and 2 years after treatment initiation by different validated criteria.Results: In total, 27 patients (100% women, mean age 48.9 ± 9.2 years) with PBC were included. Overall response rates to fibrates by each validated criterion varied from 39 to 60% and 39–76% at 12 and 24 months after treatment combination, respectively. Combination therapy resulted in a significant decrease in ALT and ALP only after 2 years, while GGT significantly improved in the first year of treatment. Treatment response rates at 1 and 2 years appear to be comparable between ciprofibrate and bezafibrate using all available criteria.Conclusion: Our findings endorse the efficacy of fibrate add-on treatment in PBC patients with suboptimal response to UDCA. Ciprofibrate appears to be at least as effective as bezafibrate and should be assessed in large clinical trials as a possibly new, cheaper, and promising option for treatment of UDCA-unresponsive PBC patients.
Acute/Chronic Responses of Combined Training on Serum Pro-thermogenic/Anti-inflammatory Inducers and Its Relation With Fed and Fasting State in Overweight Type 2 Diabetic Individuals
Authors: Bonfante Ivan Luiz Padilha , Duft Renata Garbellini , Mateus Keryma Chaves da Silva , Trombeta Joice Cristina dos Santos , Finardi Enrico Antonio Rautenberg , Ramkrapes Ana Paula Boito , Brunelli Diego Trevisan , Mori Marcelo Alves da Silva , Chacon-Mikahil Mara Patricia Traina , Velloso Licio Augusto , Cavaglieri Cláudia Regina 
Published: January 2022

Concentrations of pro-thermogenic/anti-inflammatory inductors are influenced by fed/fasting, sedentary/trained states, and metabolic pattern. However, there is a lack of information on the interactions of these conditions, especially in humans. Thus, the present study aimed to evaluate the chronic and acute training responses as well as the fed/fasted states of serum pro-thermogenic/anti-inflammatory inducers in overweight type 2 diabetics individuals. Fifteen individuals with type 2 diabetes [body mass index (BMI): 29.61 ± 3.60 kg/m2; age: 50.67 ± 3.97 years] participated in the study. In the pre- and post-experimental periods, baseline clinical parameters analyses were performed. Pro-thermogenic/anti-inflammatory inductors were evaluated pre/post-baseline and before, shortly after, and after 30′ and 60′ in the first and last sessions of a 16-week combined training (CT) period. These inducers were also compared for fasting and feeding before and after the training period. CT has improved baseline physical fitness, metabolic pattern, and it has also increased interleukin (IL)33 and FNDC5/irisin. In the first training session, there was a decrease in IL4, IL13, and IL33, besides an increase in FNDC5/irisin, and natriuretic peptides. In the last training session, there was an increase in natriuretic peptides and bone morphogenic protein 4 (BMP4). Differences in responses between the first and last training sessions were observed at certain post-session times for IL4, IL33, and natriuretic peptides, always with higher concentrations occurring in the last session. In evaluating the area under the curve (AUC) of the first and last training session, FNDC5/irisin, natriuretics peptides, and meteorin-like showed increased areas in the last training session. The pre-training fed state showed an increase in IL4 and IL33, while in fasting there was an increase in meteorin-like, natriuretic peptides, and FNDC5/irisin. In the post-training, IL4, IL13, and IL33 were increased in the fed state, while meteorin-like, natriuretic peptides, and FNDC5/irisin remained increased in the fast. Adaptation to physical training and a better metabolic pattern favor an improvement in the acute secretory pattern in part of pro-thermogenic and anti-inflammatory substances analyzed. The fed and fasting states also interfere differently in these substances, where fasting interferes with the increase of myokines, while the fed state induces an increase in interleukins.Clinical Trial Registration: [http://www.ensaiosclinicos.gov.br/rg/RBR-62n5qn/], identifier [U1111-1202-1476].