bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response of soil-pile-superstructure-quay wall system to lateral displacement under horizontal and vertical earthquake excitations
Authors: chen weiyun , Xu Ling-Yu , Cai Fei , Song Zhu , Pan Jing-Min , Chen Guo-Xing 
Published: April 2022

Abstract
The excess pore water pressure (EPWP) generated under the combined vertical and horizontal earthquake excitations is generally greater than that under the unidirectional excitation, which may further affect the dynamic response of soil-pile-superstructure-quay wall (SPSQ) system. This study conducted a coupled effective-stress analysis for the response of SPSQ system to liquefaction-induced lateral displacement under horizontal and vertical earthquake excitations. To accurately describe the lateral displacement behind the quay wall, the liquefaction behavior of soils was described by a modified generalized plasticity model with parameters properly determined from laboratory tests. The numerical model of the SPSQ system was validated against the previously reported centrifuge model tests. The results show that the earthquake excitation with abundant low-frequency component causes greater residual lateral displacements of footing (ux,RF) and quay wall (ux,RQ ) than that with abundant high-frequency component. The ux,RF and ux,RQ tend to increase as the peak vertical acceleration increases for both vertical and inclined piles. Increasing the fixity of the quay wall significantly reduces the influence of vertical ground motion on the ux,RF and ux,RQ. The polarity reversal of the vertical ground motion also has a significant effect on the ux,RF and ux,RQ and should be considered in the analyses. In addition, the lateral displacement of liquefied ground causes an amount of rotation of the cap of the inclined pile, probably leading to the potential shear failure at the head of piles.
Successful treatment of inflammatory myofibroblastic tumor with surgery and radiochemotherapy and review of the literature
Authors: Guo Haiwei , Jiang Mingyun , Cai Juanjuan , Liu Ruiqi , Yao Weiping , Liang Xiaodong , Zhang Haibo 
Published: April 2022

Abstract
Background
Inflammatory myofibroblastic tumors (IMTs) are rare soft-tissue neoplasms. Accordingly, there is no standardized therapy for unresectable or advanced IMT. Chemotherapy, radiotherapy, and targeted molecular therapy play an important role in unresectable or advanced IMT.
Case presentation:
We present a 54-year-old man with a cough and chest distress case report. The positron emission tomography/computed tomography (PET/CT) showed that the occupying lesion was about 7.2 x 6.7 x 6.1 cm, with the SUVmax about 13.4. The thoracic surgeon performed the right upper pulmonary occupying lesion wedge resection and enlarged lymph node excision biopsy. Pathologic diagnosis revealed that the morphology of "right upper lung mass" was considered as Inflammatory Myofibroblastic Tumor (IMT). Radiotherapy was indicated at a high dose: 5400cGy in 27 fractions of 2Gy over 5 weeks were delivered combined with cisplatin. The side effects of concurrent radiochemotherapy were grade I myelosuppression with WBC 3.22 x10^9/L during concurrent radiochemotherapy and grade I radiation pneumonitis 6 months after radiochemotherapy. The patient was given a CT/MRI and hematological index every 3 months and experienced no more adverse events. The patient survives with no tumor recurrence as of the last follow-up. Progression-free survival (PFS) exceeded 48 months.
Conclusions
We have reviewed the literature and summarized and discussed the radiotherapy treatment options and challenges for IMT. Radiotherapy played an essential role in unresectable or advanced IMT. We first reported surgery and high-dose radiotherapy combined with chemotherapy treatment for local advanced IMT. Surgery is the first choice for IMT, Concurrent radiochemotherapy may be considered an intensive treatment for local progress, local recurrence, and nonresectable IMT patients.
Improvements in classification of left and right foot motor intention using modulated steady-state somatosensory evoked potential induced by electrical stimulation and motor imagery
Authors: Bian Yan , Zhao Li , Li Jiaying , Guo Tong , Fu Xing , Qi Hongzhi 
Published: April 2022

Abstract
Background
In recent years, motor imagery-based brain-computer interface (MI-BCI) has been applied to motor rehabilitation in patients with motor dysfunction. However, traditional MI-BCI is rarely used for foot motor intention recognition because the motor cortex regions of both feet are anatomically close to each other, and traditional event-related desynchronization (ERD) patterns for MI-BCI have insufficient spatial discrimination.
Methods
This study introduced steady-state somatosensory evoked potentials (SSSEPs) by synchronous bilateral feet electrical stimulation at different frequencies, which were used as carrier signals modulated by unilateral foot motor intention. Fifteen subjects participated in MI and MI-SSSEP tasks. A Riemannian geometry classifier with a task-related component analysis (TRCA) spatial filter was proposed to demodulate the variation in SSSEP features and discriminate the left and right foot motor intentions.
Results
The feature outcomes indicated that the amplitude and phase synchronization of the SSSEPs could be well modulated by unilateral foot MI tasks under the MI-SSSEP paradigm. The classification results revealed that the modulated SSSEP features played an important role in the recognition of left-right foot discrimination. Moreover, the proposed TRCA-based method outperformed the other three methods and improved the foot average classification accuracy to 81.07 ± 13.29%, with the highest accuracy attained at 97.00%. Compared with the traditional MI paradigm, the foot motor intention recognition accuracy of the MI-SSSEP paradigm was significantly improved, from nearly 60% to more than 80%.
Conclusions
This work provides a practical method for left-right foot motor intention recognition and expands the application of MI-BCI in the field of lower-extremity motor function rehabilitation.
Choroidal thickness and vascularity index in Chinese children with high hypermetropia using optical coherence tomography (OCT)
Authors: zhu Dehai , Wang Hui , Li Ruoshi , Wen Jing , Li Ruiying , Zhao Jingjing 
Published: April 2022

Abstract
Objectives: The current study was to evaluate the choroidal thickness and vascularity index in Chinese children with high hypermetropia through enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: Cross-sectional study. A total of 21 children with high hypermetropia and 29 children with normal refractive status were retrospectively enrolled in the study. The measurement of the macular choroidal thickness（CT）, 7 points: the sub-foveal area point, the temporal and nasal points at a radius of 0.5-mm, 1.5-mm, and 3-mm were measured. After binarization of the OCT images, the total choroidal area (TCA), stromal area (SA) as well as the luminal area (LA) were identified and measured. The Choroidal vascularity index (CVI)was defined as the ratio of LA to TCA. The independent t-test for normal distributions and Kruskal-Wallis tests for non-normal distributions were used to compare other parameters between groups. The Tamhane's T2 test was performed to adjust for multiple comparisons between groups within each analysis.Results: The SFCT in the high hypermetropic group was significantly thicker than that in normal controls (371.32 ± 63.09 μm vs. 325.03 ± 56.67 μm, P = 0.002). At 0.5mm, 1.5 mm, and 3.0mm in diameter, the nasal choroidal sectors of the high hypermetropia eyes were significantly thicker than that of the control (P < 0.05). For the choroidal vascular parameters, S.A. values were 1101604.39± 209973.14 μm2 in the high hypermetropia eyes and 1072580.21 ± 229841.25μm2 in the control eyes; L.A. values were 2018339.60 ± 324292.51μm2, and 1786624.19 ± 238875.62μm2 in the two groups, respectively; TCA were 3112626.91 ± 521392.85μm2 and 2859204.39 ± 442897.88μm2 in the two groups. L.A. and TCA of the high hypermetropia eyes were significantly larger than that of the normal controls (P = 0.037, P = 0.002). The CVI differed significantly in the two groups (P = 0.001).Conclusion: The thicker choroidal thickness, rather than topographic features, is a biomarker of high hyperopia, but CVI is another more robust indicator.
Isolation and characterization of marine actinomycetes – bioprospecting for antimicrobial, antioxidant and anticancer properties
Authors: Kalimuthu Kasinathan , Kumaravel Mohanya , Haldar Dibyajyoti , Perumal Arumugam 
Published: April 2022

Abstract
The novel therapeutic agents are frequently produced from marine actinomycetes and are still being explored due to their vast diversity. In this research, we isolated five marine actinomycetes (BN01, BN12, BN13, BN14 and GB15) from the soil sediments of the coastal region of Chennai, Tamil Nadu, India. The morphological and physicochemical properties of the isolates were characterized. The 16S rRNA sequencing analysis showed that the isolates were belonging to two genera namely Streptomyces and Saccharopolyspora. The extracellular crude secondary metabolites were extracted from the culture filtrate of all the marine actinomycetes isolated and tested for the antimicrobial, antioxidant and anticancer potential adopting standard methods. The results revealed that the extracts of the isolates BN01, BN14, and GB15 exhibited antimicrobial activity against M. luteus, E. coli, and S. aureus, with the maximum zone of inhibition of 19 mm, 21 mm, and 27 mm respectively, at the concentration of 10 mg/mL. The extract of the isolate BN12 showed excellent radical scavenging activity of 97.75 % at the concentration of 60 µg/mL and has the half-maximal inhibitory concentration (IC50) of 8.66 µg/mL. The anticancer activity results showed that the extract of the isolate BN12 had better inhibitory activity against the MCF 7 cell line with the IC50 value of 261.01 µg/µL.
A Method for Comparing and Selecting Static Code Analysis Tools in Software Development Projects
Authors: Haertel Christian , Pohl Matthias , Staegemann Daniel , Turowski Klaus 
Published: April 2022

Abstract
To enable reliable software releases, automated concepts are increasingly being sought as part of the necessary test processes to be able to detect potential errors at an early stage. Static code analysis tools (SCATs) are especially suited for this purpose, as these testing tools perform their checks without actually executing the software. Thus, they represent an important part in the test suite. For the problem of carefully selecting such a tool for project use, a method for the construction of SCAT comparison catalogs is developed in this article to allow to contrast different tools and to evaluate them with respect to derived criteria. While the comparison categories are derived from established software quality models by taking into account the specifics of SCATs, multi criteria decision making procedures employing linguistic predicates are used to determine the most suitable test tool for each case. The artifact is demonstrated and evaluated in an artificial SCAT selection process which involves FindBugs, checkstyle, and PMD. A Method for Comparing and Selecting Static Code Analysis Tools Finally, potential extensions of the proposed method are outlined and its simple modifiability to other software decision situations is set forth.
Virtual Reality in the Intensive Care Unit to improve Noninvasive Ventilation Tolerance: a case report
Authors: Bataille Benoît , Iozzia Jean Christophe , Cocquet Pierre , Silva Stein 
Published: April 2022

Abstract
PurposeThis case report describes the use of virtual reality (VR) to improve noninvasive ventilation (NIV) tolerance in the intensive care unit (ICU).Clinical FeaturesA 65-yr-old man was admitted to the ICU with hypercapnic respiratory failure resulting from an acute exacerbation of COPD. He had type-2 diabetes mellitus and post-smoking COPD but no history of psychiatric disease. Carbon dioxide narcosis required NIV and resulted in the recovery of normal consciousness. However, the tolerance and comfort of the patient during the 1-hour sessions repeated twice a day were moderate, leading us to propose virtual reality to improve his well-being. To combine VR with NIV, a Bridge-free NIV mask was necessary. The tolerability of NIV was significantly improved and the patient was very satisfied and enthusiastic, demonstrating the possibility of effectively combining VR with NIV to improve patient well-being.ConclusionsThis case paves the way to combine advantageously VR with NIV to improve the well-being of ICU patients.
SARS-CoV-2 BA.1 and BA.2 co-infection detected by genomic surveillance in Brazil, January 2022
Authors: Oliveira Cristina , Romano Camila Malta , Sussuchi Luciane , Cota Bianca Della Croce Vieira , Levi José Eduardo 
Published: April 2022

Abstract
In January 2022, the genomic surveillance of DASA laboratories identified a SARS-CoV-2 BA.1 and BA.2 co-infection in a sample from a patient resident in Brazil. The bioinformatics protocols using DragenTM Covid Lineage App do not allow the detection of recombinants or mixed-infections. Therefore, the number of co-infections is certainly underestimated.
Population health and burden of disease profile in Sierra Leone from 1990 to 2017
Authors: Zembe Jolleen , Senkubuge Flavia , Cronje Tanita , Achoki Tom 
Published: April 2022

Abstract
Background
Sierra Leone, in West Africa, is one of the poorest developing countries in the world. Sierra Leone has experienced several recent challenges namely, a civil war from 1991 to 2002, a massive Ebola outbreak from 2014 to 2016, followed by floods and landslides in 2017.In this study, we quantified the burden of disease in Sierra Leone over a 27-year period, from 1990 to 2017.
Methodology
In this cross-sectional analysis, we analysed secondary data from the Institute of Health Metrics and Evaluation, Global Burden of Disease (GBD) study. We quantified patterns of burden of disease, injuries, and risk factors in Sierra Leone. We report GBD metrics including mortality rates, years of life lost and risk factors for all ages and both sexes from 1990 to 2017.
Results
From 1990 to 2017, mortality rates for all ages and sexes have declined in Sierra Leone although mortality rates remain some of the highest when compared to other developing countries. The burden of communicable, maternal, neonatal, and nutritional (CMNN) diseases are greater than the burden of non-communicable diseases (NCDs) due to the prevalence of endemic diseases in Sierra Leone. The most important CMNNs associated with premature mortality included respiratory infections, neglected tropical diseases, malaria and HIV-Aids. Life expectancy has increased from 37 years to 52 years
Conclusion
Sierra Leone’s health status is gradually improving following the civil war and Ebola outbreak. Sierra Leone has a double burden of disease with CMNNs leading and NCDs progressively increasing. Despite these challenges, Sierra Leone has promising initiatives and programs pursuing the Universal Health Coverage 2030 Sustainable Developmental Goals Agenda. There is need for accountability of available resources, clear rules and expected roles for non-governmental organisations to ensure a level playing field for all actors to rebuild the health system.
Medium-Temperature-Oxidized GeO Resistive-Switching Random-Access Memory and Its Applicability in Processing-in-Memory Computing
Authors: Mohanan Kannan Udaya , Cho Seongjae , Park Byung-Gook 
Published: April 2022

Abstract
Processing-in-memory (PIM) is emerging as a new computing paradigm to replace the existing von Neumann computer architecture for data-intensive processing. For the higher end-user mobility, low-power operation capability is more increasingly required and components need to be renovated to make a way out of the conventional software-driven artificial intelligence. In this work, we investigate the hardware performances of PIM architecture that can be presumably constructed by resistive-switching random-access memory (ReRAM) synapse fabricated with a relatively larger thermal budget in the full Si processing compatibility. By introducing a medium-temperature oxidation (MTO) in which the sputtered Ge atoms are oxidized at a relatively higher temperature compared with the ReRAM devices fabricated by physical vapor deposition (PVD) at room temperature, higher device reliability has been acquired. Based on the empirically obtained device parameters, a PIM architecture has been conceived and a system-level evaluations have been performed in this work. Considerations include the cycle-to-cycle variation in the GeOx ReRAM synapse, analog-to-digital converter (ADC) resolution, synaptic array size, and interconnect latency for the system-level evaluation with the Canadian Institute for Advance Research (CIFAR)-10 dataset. A fully Si processing compatible and robust ReRAM synapse and its applicability for PIM are demonstrated.
Boosting visible-light-driven hydrogen evolution of polymer photocatalysts by a universal main-chain-engineering strategy of hydrophilic non-conjugated building blocks
Authors: Chang Chih-Li , Lin Wei-Cheng , Ting Li-Yu , Shih Chin-Hsuan , Chen Shin-Yuan , Huang Tse-Fu , Tateno Hiroyuki , Jayakumar Jayachandran , Chu Che-Yi , Chen Chin-Wen , Yu Chi-Hua , Lu Yu-Jung , Mochizuki Takehisa , Chou Ho-Hsiu 
Published: April 2022

Abstract
Photocatalytic water splitting is attracting considerable interest because it enables abundant solar energy to be converted into hydrogen for use as a zero-emission fuel or chemical feedstock. Herein, we present a universal approach for inserting hydrophilic non-conjugated building blocks into the main-chain of conjugated polymers to produce a series of discontinuously conjugated polymer (DCP) photocatalysts. Water can effectively be brought into the interior of DCPs through these hydrophilic non-conjugated building blocks, resulting in effective water/polymer interfaces inside the bulk DCPs in both thin-film and solution. P-10HEG with 10 mol% ethylene glycol-based hydrophilic building blocks achieved a record high apparent quantum yield of 17.82% under 460 nm monochromatic light irradiation in solution and an excellent hydrogen evolution rate of 16.8 mmol m− 2 h− 1 in thin-film. Molecular dynamics simulation shows a trend similar to that in experiments, which confirms that main-chain engineering increases the possibility of a water-DCP interaction. Unlike the previous strategy of maintaining a long conjugation length, our approach results in DCP photocatalysts with an interrupted conjugation length that remains efficient photocatalysis.
Correlation between health promotion behavior and quality of life in survivors of stanford B aortic dissection
Authors: Zhou Jiamei , Tu Jianxin , Wang Fei , Yin Furong , Zhao benli , Zhang Linxue 
Published: April 2022

Abstract
Background:To understand the current situation of health promotion behavior and quality of life of aortic dissection survivors and the correlation between them. Methods: The associations between stanford B aortic dissection survivors’health promotion behavior scores and health status questionnaire (SF-36) scores was determined with pearson correlation coefficients. Associations between health promotion behaviorscores and health status questionnaire (SF-36) scores were analyzed with multivariable regression analysis. Results: 131 stanford B aortic dissection survivors were evaluated with the self-developed aortic dissection patient health promotion behavior scale and health status questionnaire (SF-36) , the score of aortic dissection health promotion behavior (85.05±11.28), The score of quality of life (61.44±18.41) showed that the health promotion behavior of stanford B AD survivors was positively correlated with the quality of life (r=0.403，P＜0.01). Regression analysis showed that age, education, sick time，behavior motivation and exercise entered the regression equation of quality of life (R2=0.464，P＜0.01) . Conclusion:Stanford B AD survivors had a lower quality of life, Medical staff can formulate intervention measures from two aspects of behavioral motivation and exercise to improve the quality of life of ad survivors.
The primary goblet cell adenocarcinoma of the rectum: A Case Report
Authors: Fan Ruirui , Gao Jie , Zeng Dehua , Fu Xiaoyu , Lu Mingzhi 
Published: April 2022

Abstract
Goblet cell adenocarcinoma (GCA) is a rare tumor, and it is characterized by its unique combination of neuroendocrine and adenocarcinoma. GCA occurs mainly in the appendix. Currently, there is no primary GCA of the rectum in the 2019 World Health Organization classification of colorectal tumors. Here, we report a case of the primary GCA of the rectum that combined examinations via histological morphology, immunohistochemistry, transmission electron microscopy (TEM), and molecular detection. We demonstrate that this tumor is the primary rectum GCA for the first time worldwide. Our work will help to improve the diagnosis of the primary GCA of the rectum and avoid misdiagnosis and mistreatment.
Locally advanced rectal cancer receiving total neoadjuvant therapy combined with nivolumab: A case report and literature review.
Authors: Mori Ryota , Uemura Mamoru , Sekido Yuki , Hata Tsuyoshi , Ogino Takayuki , Takahashi Hidekazu , Miyoshi Norikatsu , Mizushima Tsunekazu , Doki Yuichiro , Eguchi Hidetoshi 
Published: April 2022

Abstract
Background: The standard treatment for locally advanced rectal cancer (LARC) is preoperative chemoradiotherapy (CRT) followed by surgery and adjuvant chemotherapy. However, it has been suggested that intensification of neoadjuvant treatment with polychemotherapy added before CRT instead of as an adjuvant chemotherapy is better tolerated and associated with a higher pathological complete response (pCR) rate. This concept is known as total neoadjuvant therapy (TNT). Recently, the addition of immunotherapy to preoperative CRT has been reported to be useful in LARC patients with mismatch-repair-deficiency and high levels of microsatellite instability (MSI-H), but there are no reports showing the therapeutic effect of nivolumab in combination with TNT.Case presentation: A 23-year-old man had frequent diarrhea. Preoperative examination revealed two adenocarcinomas in the rectum. The larger tumor was located at the peritoneal reflection, and its anterior border close to the prostate (<1 mm); there were eight enlarged pararectal lymph nodes. Considering the size and depth of the tumor, it was judged that radical resection with sufficient margins would be difficult. Therefore, it was decided that TNT would be performed. At first, CAPOX (capecitabine and L-OHP) was administered, followed by[AK1] preoperative CRT(RT:50.4 Gy and capecitabine). During this period, genetic testing diagnosed this patient as MSI-H, so additional nivolumab was administered after CRT. Colonoscopy revealed that the larger tumor was no longer detectable, so robot-assisted intersphincteric resection and bilateral lateral lymph node dissection was performed. The diagnosis of pCR was made for the larger tumor and partial response was achieved for the smaller tumor, and no lymph node metastasis was found. Major complications were not observed and the patient was discharged on the 14th day after surgery. He was followed up without adjuvant chemotherapy and is alive and recurrence free after 9 months.Conclusion: A case of LARC with MSI-H was treated with TNT with nivolumab, resulting in pCR and complete radical resection. This result suggests that nivolumab in addition to TNT can be an option as a preoperative strategy for LARC with MSI-H. [AK1]We edited this sentence for concision.