bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher Minimum Wages Reduce Capital Expenditures
Authors: T. Gustafson Matthew , D. Kotter Jason 
Published: May 2022

Using cross-state and intertemporal variation in whether a state’s minimum wage is bound by the federal minimum wage, we provide evidence that minimum wage increases lead U.S. public firms in minimum-wage-sensitive industries (i.e., retail, restaurant, and entertainment) to cut capital expenditures. These effects are concentrated one to two years after the law goes into effect. Prior to the minimum wage increase, investment trends are similar across minimum-wage-sensitive firms in bound versus unbound states, and we find little evidence that minimum wage changes affect U.S. public firm investment outside of these industries. This paper was accepted by Victoria Ivashina, finance. Supplemental Material: The internet appendix is available at https://doi.org/10.1287/mnsc.2022.4430 .
Outcomes following surgical management of proximal hamstring tendon avulsions
Authors: Hillier-Smith Ryan , Paton Bruce 
Published: May 2022

Aims Avulsion of the proximal hamstring tendon origin can result in significant functional impairment, with surgical re-attachment of the tendons becoming an increasingly recognized treatment. The aim of this study was to assess the outcomes of surgical management of proximal hamstring tendon avulsions, and to compare the results between acute and chronic repairs, as well as between partial and complete injuries. Methods PubMed, CINAHL, SPORTdiscuss, Cochrane Library, EMBASE, and Web of Science were searched. Studies were screened and quality assessed. Results In all, 35 studies (1,530 surgically-repaired hamstrings) were included. Mean age at time of repair was 44.7 years (12 to 78). A total of 846 tears were acute, and 684 were chronic, with 520 tears being defined as partial, and 916 as complete. Overall, 92.6% of patients were satisfied with the outcome of their surgery. Mean Lower Extremity Functional Score was 74.7, and was significantly higher in the partial injury group. Mean postoperative hamstring strength was 87.0% of the uninjured limb, and was higher in the partial group. The return to sport (RTS) rate was 84.5%, averaging at a return of 6.5 months. RTS was quicker in the acute group. Re-rupture rate was 1.2% overall, and was lower in the acute group. Sciatic nerve dysfunction rate was 3.5% overall, and lower in the acute group (p < 0.05 in all cases). Conclusion Surgical treatment results in high satisfaction rates, with good functional outcomes, restoration of muscle strength, and RTS. Partial injuries could expect a higher functional outcome and muscle strength return. Acute repairs result in a quicker RTS with a reduced rate of re-rupture and sciatic nerve dysfunction. Cite this article: Bone Jt Open 2022;3(5):415–422.
Carbon Analysis of Wood Composite Panels
Authors: Puettmann Maureen Elaine 
Published: May 2022

Abstract
Wood composite panels (WCP) are well known for their environmentally friendly attributes of being sustainable, renewable, biodegradable, and predominantly made from wood residues generated during lumber and plywood production. This paper focuses on the ability of WCPs to store carbon for long periods of time in nonstructural applications such as cabinets, furniture, and flooring. WCPs, include particleboard, medium density fiberboard (MDF), and hardboard–engineered wood siding and trim (EWST). These panels are anticipated to have an average service life of 25–30 years. In 2019, there was an estimated 291 million cubic meters (m3) of WCPs in use in North America that corresponds to a carbon pool of 354 million metric tons of carbon dioxide equivalents. This WCP carbon pool is enough to offset 24 years of cradle-to-gate cumulative carbon emissions (fossil and biogenic sources) emitted during production of these panels. In other words, producing and using WCPs stores carbon for long periods because the amount of carbon emitted during the production of the panels is far less than what the panels themselves are capable of storing over their lifetime of product use.
Effects of room temperature and cold storage on the metabolic and haemostatic properties of whole blood for acute normovolaemic haemodilution
Authors: Ichikawa Junko , Kouta Masaki , Oogushi Masako , Komori Makiko 
Published: May 2022

Background
Acute normovolaemic haemodilution (ANH), as a blood-conservation technique, avoids the need for allogeneic blood transfusions. The historic practice of cold-storing type-O whole blood (WB) in military fields popularised the transfusion of refrigerated WB to treat acute bleeding. In this study, we compared the effects of room temperature (RT) and refrigeration up to 24 hours on the coagulation properties of WB for ANH.

Materials and methods
Each WB sample, collected from 12 male volunteers, was divided into two parts, one stored at RT and the other refrigerated for 24 hours. Complete blood counts (CBC), blood gas levels, and coagulation profiles were measured, and rotational thromboelastometry (ROTEM) measurements were performed at the initial collection time point (baseline) and at 6, 12, and 24 hours after initial collection.

Results
The preservation of platelet aggregation response induced by arachidonic acid and adenosine diphosphate was better in cold-stored WB compared to that in RT-stored WB. The platelet aggregation response induced by thrombin receptor-activating peptide 6 was significantly decreased in all samples after 24 hours of storage when compared with that at baseline. The lactate levels in WB stored at RT increased significantly after 6 hours of storage compared to that of cold-stored samples. There were no significant differences in CBC, coagulation parameters, and ROTEM variables between the cold-stored and RT-stored WB samples.

Conclusion
WB for ANH stored in the refrigerator showed better metabolic characteristics after 6 hours of storage and better aggregation response after 12 hours of storage than WB stored at RT.
Dealing with inconclusive SARS-CoV-2 PCR samples—Our experience
Authors: Stoykova Zhivka , Kostadinova Tsvetelina , Todorova Tatina , Niyazi Denis , Bozhkova Milena , Bizheva Svetomira , Stoeva Temenuga 
Published: May 2022

Purpose
Early confirmation of SARS-CoV-2 is a key point in the timely management of infected patients and contact persons. Routine diagnostics of COVID-19 cases relies on RT-PCR detection of two or three unique sequences of the virus. A serious problem for the laboratories is how to interpret inconclusive samples which are positive for only one of the SARS-CoV-2 specific genes.

Materials and methods
A total of 16364 naso-oropharyngeal swabs were collected and tested with SARS-CoV-2 Real-TM kit (Sacace Biotechnologies, Italy) between May and September 2020. We retrospectively analyzed their amplification plots to determine the number of inconclusive samples. We also reviewed the medical records to summarize the patient’s COVID-19 testing history and basic demographic characteristics.

Results
We obtained 136 (0.8%) inconclusive samples with amplification signal only for the N-gene. Thirty-nine of the samples were excluded from further analysis as no additional data were available for them. Of the rest of the samples, the majority– 48% (95% CI 38–59%) had a previous history of SARS-CoV-2 positivity, 14% (95% CI 8–23%)–a subsequent history of positivity and 37% (95% CI 28–48%) were considered as false positive.

Conclusion
A substantial proportion of the inconclusive results should be considered as positive samples at the beginning or the end of the infection. However, the number of false-positive results is also significant and each patient’s result should be analyzed separately following the clinical symptoms and epidemiological data.
Does it come from tobacco? Young adults’ interpretations of the term “tobacco-free nicotine” in a cross-sectional national survey sample
Authors: Morean Meghan E. , Bold Krysten W. , Davis Danielle R. , Kong Grace , Krishnan-Sarin Suchitra , Camenga Deepa R. 
Published: May 2022

Background
“Tobacco-free” nicotine (TFN) e-cigarettes and nicotine pouches containing synthetic nicotine are increasingly available. The term TFN may lead to reduced risk perceptions and increased use intentions relative to tobacco-derived nicotine products. Effectively communicating messages about TFN may depend on the public’s ability to differentiate TFN from tobacco-derived nicotine. Our goals were to examine knowledge about the source(s) of nicotine in commonly used products and beliefs about what TFN means.

Methods
In 2021 we surveyed 2464 young adults (18–25 years) online. Participants reported whether cigarettes, smokeless tobacco, e-cigarettes, and nicotine pouches contain nicotine that comes from tobacco (always, sometimes, never). Correct responses were “always” for cigarettes/smokeless and “sometimes” for e-cigarettes/pouches. Participants also reported “what [they] think TFN e-cigarettes/vapes contain” (nicotine only; tobacco only; both nicotine and tobacco; neither nicotine nor tobacco). We ran unadjusted and adjusted models examining correct responses for nicotine source and TFN contents by past-month product use status (cigarettes, smokeless, e-cigarettes, pouches).

Results
Rates of correctly identifying nicotine source were modest (23.6% pouches—61.9% cigarettes). Except smokeless tobacco, using a given product was associated with identifying its nicotine source correctly in unadjusted models. Participants reported “TFN” means a product contains nicotine only (57.8%), tobacco only (10.8%), both (14.1%), or neither (17.1%).

Conclusions
There is confusion about the source of nicotine in products, and many young adults incorrectly interpreted TFN to mean something other than containing nicotine but no tobacco. Regulatory efforts may be needed to restrict using the term “tobacco-free nicotine” on product labeling and advertising.
Long-term oncological outcomes after oral cancer surgery using propofol-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia: A retrospective cohort study
Authors: Miao Lingju , Lv Xiang , Huang Can , Li Ping , Sun Yu , Jiang Hong 
Published: May 2022

Background
Previous studies have shown that the anesthetic technique may influence long-term outcomes after cancer surgery. However, the association between the anesthetic technique and long-term oncological outcomes after oral cancer surgery remains unclear. Therefore, we conducted this study to address this gap.

Methods
We reviewed the electronic medical records of patients who underwent elective oral cancer surgery between January 2014 and December 2015. The patients were grouped based on the anesthesia maintenance: either propofol or sevoflurane. Propensity score matching in a 1:1 ratio was performed to deal with the potential confounding effects of baseline characteristics. Univariate and multivariate Cox regression analyses were performed to compare hazard ratios (HRs) and identify the risk factors for death and recurrence. Survival analysis was performed using the Kaplan–Meier method, and survival curves were constructed from the date of surgery to death.

Results
In total, 1347 patients were eligible for analysis, with 343 and 1004 patients in the propofol and sevoflurane groups, respectively. After propensity score matching, 302 patients remained in each group. Kaplan–Meier survival curves demonstrated the 5-year overall and recurrence-free survival rates of 59.3% and 56.0% and 62.7% and 56.5% in the propofol and sevoflurane groups, respectively. There was no significant difference in overall survival or recurrence-free survival between the groups. The multivariate Cox analysis verified this conclusion with HRs of 1.10 and 1.11 for overall survival and recurrence-free survival, respectively, in the sevoflurane group. Older age, advanced tumor-node-metastasis (TNM) stage, and American Society of Anesthesiologists class III were associated with poor overall survival. Patients with advanced TNM stage and poorly differentiated squamous cell carcinoma had a higher recurrence risk than their counterparts.

Conclusion
The overall and recurrence-free survival rates were similar between propofol-based intravenous anesthesia and sevoflurane volatile anesthesia in patients who underwent oral cancer surgery.
ESTIMASI PARAMETER DAN PENGUJIAN HIPOTESIS MODEL GEOGRAPHICALLY WEIGHTED GENERALIZED GAMMA REGRESSION
Authors: Yasin Hasbi , Purhadi Purhadi , Choiruddin Achmad 
Published: May 2022

Each location has unique characteristics, which are different from other locations which give rise to spatial effects between locations. Therefore, the Generalized Gamma Regression (GGR) model is not suitable to be applied to this problem. The solution is to use a Geographically Weighted Generalized Gamma Regression (GWGGR) model which produces different parameters for each observation location. This study aims to estimate GWGGR parameters using the Berndt-Hall-Hall-Hausman (BHHH) algorithm. After parameter estimation is performed, the hypothesis testing procedure is used to test the similarity of parameters between the generalized gamma regression and GWGGR and to test the significance of the independent variables in the model, either simultaneously using the Maximum Likelihood Ratio Test (MLRT) or partially using the Z-test. Keywords: BHHH, Generalized Gamma, GGR, GWGGR, MLRT.
Sirt1 overexpression attenuates Western‐style diet‐induced aortic stiffening in mice
Authors: Gogulamudi Venkateswara R. , Machin Daniel R. , Henson Grant D. , Lim Jisok , Bramwell Richard C. , Durrant Jessica R. , Donato Anthony J. , Lesniewski Lisa A. 
Published: May 2022

AbstractIncreased arterial stiffness is a cardiovascular disease risk factor in the setting of advancing age and Western diet (WD) induced obesity. Increases in large artery stiffness, as measured by pulse wave velocity (PWV), occur within 8 weeks of WD feeding in mice. Sirtuin‐1 (Sirt1), a NAD‐dependent deacetylase, regulates cellular metabolic activity and activation of this protein has been associated with vasoprotection in aged mice. The aim of the study was to elucidate the effect of global Sirt1 overexpression (Sirttg) on WD‐induced arterial stiffening. Sirt1 overexpression did not influence PWV in normal chow (NC) fed mice. However, PWV was higher in wild‐type (WT) mice (p < 0.04), but not in Sirttg mice, after 12 weeks of WD and this effect was independent of changes in blood pressure or the passive pressure diameter relation in the carotid artery. Overexpression of Sirt1 was associated with lower collagen and higher elastin mRNA expression in the aorta of WD fed mice (both p < 0.05). Although MMP2 and MMP3 mRNA were both upregulated in WT mice after WD (both p < 0.05), this effect was reversed in Sirttg mice compared to WT mice fed WD (both p < 0.05). Surprisingly, histologically assessed collagen and elastin quality were unchanged in the aortas of WT or Sirttg mice after WD. However, Sirttg mice were protected from WD‐induced glucose intolerance, although there was no difference in insulin tolerance between groups. These findings demonstrate a vasoprotective effect of Sirt1 overexpression that limits the increase in arterial stiffness in response to consumption of a WD.
Phytoremediation of pollutants from wastewater: A concise review
Authors: Khan Atta Ullah , Khan Allah Nawaz , Waris Abdul , Ilyas Muhammad , Zamel Doaa 
Published: May 2022

Abstract
As there is a global water crisis facing the whole world, it is important to find alternative solutions to treat wastewater for reuse. Hence, plants have an effective role in removing pollutants from wastewater, which has been emphasized in this review article. Biological treatment of wastewater can be considered an eco-friendly and cost-effective process that depends on in the future. Living organisms, including plants, can remediate pollutants in wastewater, especially in agricultural fields, such as dyes, heavy metals, hydrocarbons, pharmaceuticals, and pesticides. This review discusses the different activities of plants in pollutant elimination from wastewater and sheds light on the utilization of plants in this scope. This review focuses on the remediation of the most common contaminants present in wastewater, which are difficult to the removal with microorganisms, such as bacteria, fungi, and algae. Moreover, it covers the major role of plants in wastewater treatment and the potential of phytoremediation as a possible solution for the global water crisis.
Between Rack Rents and Paternalism: Economic Behaviour and the Lease Market in Westphalia, with a Particular Focus on the 19th Century
Authors: Bracht Johannes , Scholten-Buschhoff Friederike 
Published: May 2022

Abstract
Departing from research on Westphalian leases between 1600 and 1900 the paper discusses the lease market of and price determination on three Westphalian estates. While economic history approaches suppose that leases can be seen as market relations and are therefore useful indicators to measure agricultural productivity, a more anthropological perspective emphasises the social relations between lessor (here: noble estate owner) and leaseholders. The choice of an adequate perspective has significant implications for research on agricultural productivity based on rents and leases. Our results indicate that the contractual arrangement of leasehold (well defined duration, announcement, auctions) was used to achieve the highest possible leases. However, at least until the 1830s, demand for leasehold land was rather low and leaseholders could benefit from a lack of competition. Price determination of leases resulted in rents below the Ricardian rent. Therefore, we argue that important assumptions of the established price approach, which uses leases as proxies for productivity, are not met and the analysis of agricultural productivity requires additional evidence on the leaseholder’s income and profit.
Global perspective on pediatric growth hormone registries: a systematic review
Authors: Eslami Parisa , Sayarifard Fatemeh , Safdari Reza , Shahmoradi Leila , Karbasi Zahra 
Published: May 2022

Abstract

Background
Registries are considered valuable data sources for identification of pediatric conditions treated with growth hormone (GH), and their follow-up. Currently, there is no systematic literature review on the scope and characteristics of pediatric GH registries. Therefore, the purpose of this systematic review is to identify worldwide registries reported on pediatric GH treatment and to provide a summary of their main characteristics.

Content
Pediatric GH registries were identified through a systematic literature review. The search was performed on all related literature published up to January 30th, 2021. Basic information on pediatric GH registries, their type and scope, purpose, sources of data, target conditions, reported outcomes, and important variables were analyzed and presented.

Summary
Twenty two articles, reporting on 20 pediatric GH registries, were included in this review. Industrial funding was the most common funding source. The main target conditions included in the pediatric GH registries were: growth hormone deficiency, Turner syndrome, Prader Willi syndrome, small for gestational age, idiopathic short stature, and chronic renal insufficiency. The main objectives in establishing and running pediatric GH registries were assessing the safety and effectiveness of the treatment, describing the epidemiological aspects of target growth conditions and populations, serving public health surveillance, predicting and measuring treatment outcomes, exploring new and useful aspects of GH treatment, and improving the quality of patient care.

Outlook
This systematic review provides a global perspective on pediatric GH registries which can be used as a basis for the design and development of new GH registry systems at both national and international levels.
The effect of advanced maternal age on perinatal outcomes in nulliparous pregnancies
Authors: Elçi Gülhan , Çakmak Ayşegül , Elçi Erkan , Sayan Sena 
Published: May 2022

Abstract

Objectives
In the current study, we aimed to evaluate the effect of advanced maternal age on perinatal outcomes in nulliparous singleton pregnancy.

Methods
The perinatal outcome data of 11,366 patients who gave birth between 2015 and 2020 were evaluated retrospectively. Patients were subgrouped according to their age as control group (C) (20–29 years), late advanced maternal age group (30–34 years), advanced maternal age group (35–39 years), and very advanced maternal age group (≥40 years). Multinomial logistic regression analyses were performed to test the possible independent role of maternal age as a risk factor for adverse pregnancy outcomes.

Results
Statistically significant difference was observed between the control group and the other groups in terms of preterm delivery, preeclampsia, gestational diabetes mellitus (GDM), small gestational age (SGA), large gestational age (LGA), premature rupture of membranes (PROM), high birth weight (HBW), and perinatal mortality rates (p<0.05). An increased risk of the need for neonatal intensive care unit (NICU) and perinatal mortality was observed in groups over 35 years old.

Conclusions
Age poses a risk in terms of preterm delivery, preeclampsia, LGA, GDM, and HBW in the groups over 30 years of maternal age. The rates of PROM, NICU, and perinatal mortality increase in addition to those perinatal results in the groups above 35 years of maternal age.
Lidocaine ameliorates chronic constriction injury-induced neuropathic pain through regulating M1/M2 microglia polarization
Authors: Yuan Jiaqi , Fei Yue 
Published: May 2022

Abstract
This study is intended to explore the mechanism that lidocaine ameliorates chronic constriction injury (CCI)-induced neuropathic pain (NP) related to the polarization of M1 and M2 microglia. CCI rats were established by surgery to induce NP. The mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) of rats were determined. Microglial line HAPI cells were polarized into M1 or M2 cells using lipopolysaccharide (LPS) or interleukin (IL)-4, respectively. Immunofluorescence staining was performed to determine the Iba1/CD86- and Iba1/CD206-positive cells. Markers of M1 and M2 microglia were assessed using flow cytometry. Real-time polymerase chain reaction and enzyme-linked immunosorbent assay were performed to detect the level of mRNA and inflammatory factors. Lidocaine ameliorates CCI-induced NP, evidenced by the markedly increased values of MWT and TWL in NP rats. Lidocaine inhibited M1 microglia polarization but promoted M2 microglia polarization in a rat model of CCI-induced NP. Besides, in the in vitro experiment, lidocaine regulated M1/M2 polarization in LPS- or IL-4-treated HAPI microglia. Lidocaine ameliorates CCI-induced NP by regulating M1/M2 microglia polarization. This study investigated the biological role of lidocaine in regulating NP in rats, which may be helpful for revealing the pathogenic mechanisms of NP and provide a potential therapeutic factor.
Crystal structure of the cocrystal 1,3,5,7-tetranitro-1,3,5,7-tetrazoctane ─ 2,3-dihydroindole (1/1), C12H17N9O8
Authors: Liu Penghua , Xing Jiangtao , Wang Zhiqiang , Wang Baomin 
Published: May 2022

Abstract
C12H17N9O8, orthorhombic, Pna21 (no. 33), a = 11.376(4) Å, b = 7.966(2) Å, c = 19.076(6) Å, V = 1728.6(9) Å3, Z = 4, R

gt
(F) = 0.0373, wR

ref
(F
2) = 0.0908, T = 296 K.