bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computer-assisted correction of incongruent distal radioulnar joints in patients with symptomatic ulnar-minus variance
Authors: Estermann Lea , Urbanschitz Lukas , Reissner Lisa , Schweizer Andreas 
Published: June 2022

Our study described a computer-assisted, three-dimensional (3-D), planned surgical technique of a radial shortening osteotomy. The osteotomy of the distal radius was planned with computer assistance on 3-D bone models based on computed tomography data. The objective was to maximize the contact zone of the sigmoid notch with the ulnar head. Between 2012 and 2020 we treated 14 wrists in 11 patients with symptomatic ulnar-minus variance with a mean follow-up of 44 months (range 8 to 98) and a mean age of 28 years (range 19 to 38). Postoperatively, patients showed a decrease in pain at rest and during effort (numeric rating scale from 4.4 to 0 and 7.5 to 4.5, respectively). The range of motion postoperatively was similar to the contralateral side. Grip strength increased from 24 kg to 30 kg. The Disability of the Arm, Shoulder, and Hand and the Patient-Rated Wrist Evaluation scores were 28 and 35 postoperatively, respectively. Our technique of 3-D computer-assisted distal radioulnar joint reconstruction led to a pain reduction and improvement of the hand function in patients with symptomatic ulnar-minus variance. Level of evidence: IV
Detection of Meals and Physical Activity Events From Free-Living Data of People With Diabetes
Authors: Askari Mohammad Reza , Rashid Mudassir , Sun Xiaoyu , Sevil Mert , Shahidehpour Andrew , Kawaji Keigo , Cinar Ali 
Published: June 2022

Background: Predicting carbohydrate intake and physical activity in people with diabetes is crucial for improving blood glucose concentration regulation. Patterns of individual behavior can be detected from historical free-living data to predict meal and exercise times. Data collected in free-living may have missing values and forgotten manual entries. While machine learning (ML) can capture meal and exercise times, missing values, noise, and errors in data can reduce the accuracy of ML algorithms. Methods: Two recurrent neural networks (RNNs) are developed with original and imputed data sets to assess detection accuracy of meal and exercise events. Continuous glucose monitoring (CGM) data, insulin infused from pump data, and manual meal and exercise entries from free-living data are used to predict meals, exercise, and their concurrent occurrence. They contain missing values of various lengths in time, noise, and outliers. Results: The accuracy of RNN models range from 89.9% to 95.7% for identifying the state of event (meal, exercise, both, or neither) for various users. “No meal or exercise” state is determined with 94.58% accuracy by using the best RNN (long short-term memory [LSTM] with 1D Convolution). Detection accuracy with this RNN is 98.05% for meals, 93.42% for exercise, and 55.56% for concurrent meal-exercise events. Conclusions: The meal and exercise times detected by the RNN models can be used to warn people for entering meal and exercise information to hybrid closed-loop automated insulin delivery systems. Reliable accuracy for event detection necessitates powerful ML and large data sets. The use of additional sensors and algorithms for detecting these events and their characteristics provides a more accurate alternative.
Noncanonical Sonic Hedgehog signaling amplifies platelet reactivity and thrombogenicity
Authors: Tiwari Arundhati , Gautam Deepa , Kulkarni Paresh P. , Ekhlak Mohammad , Sonkar Vijay K. , Agrawal Vikas , Dash Debabrata 
Published: June 2022

Abstract
Sonic Hedgehog (Shh) is a morphogen in vertebrate embryos that is also associated with organ homeostasis in adults. We report here that human platelets, though enucleate, synthesize Shh from preexisting mRNAs upon agonist stimulation, and mobilize it for surface expression and release on extracellular vesicles, thus alluding to its putative role in platelet activation. Shh, in turn, induced a wave of noncanonical signaling in platelets leading to activation of small GTPase Ras homolog family member A and phosphorylation of myosin light chain in activated protein kinase-dependent manner. Remarkably, agonist-induced thrombogenic responses in platelets, which include platelet aggregation, granule secretion, and spreading on immobilized fibrinogen, were significantly attenuated by inhibition of Hedgehog signaling, thus, implicating inputs from Shh in potentiation of agonist-mediated platelet activation. In consistence, inhibition of the Shh pathway significantly impaired arterial thrombosis in mice. Taken together, the above observations strongly support a feed-forward loop of platelet stimulation triggered locally by Shh, similar to ADP and thromboxane A2, that contributes significantly to the stability of occlusive arterial thrombus and that can be investigated as a potential therapeutic target in thrombotic disorders.
A pilot study examining the suitability of the mental arithmetic task and single-item measures of affective states to assess affective, physiological, and attention restoration at a wooden desk
Authors: Lipovac Dean , Žitnik Jure , Burnard Michael D. 
Published: June 2022

AbstractPeople seem to function and feel better in indoor natural environments, including spaces furnished with wood. When restorative effects of indoor spaces are not detected, suboptimal methodological approaches may be responsible, including stress-inducing activities and measures of affective states and cognitive performance. Our primary objectives were to test (1) whether the Mental Arithmetic Task (MAT) can reliably induce stress and measure cognitive performance, and (2) whether two single-item measures of pleasure and arousal can detect changes in affective states in restoration research. Our secondary objective was to examine whether stress recovery and cognitive performance differ between indoor settings furnished with or without wood. Twenty-two participants, allocated to a space furnished with either a wooden or a white desktop, completed MAT twice, while their electrodermal and cardiovascular activity and affective states were monitored. Participants on average responded to MAT with increased subjective arousal but unchanged subjective pleasure, and with increased physiological arousal on some but not all parameters, suggesting that MAT was effortful but not necessarily stressful. Scores on MAT improved at the 2nd administration, suggesting that MAT did not induce cognitive fatigue at the 1st administration and that its role as a cognitive task in restoration research may be limited. The items assessing affective states performed well. The measured outcomes did not differ between the wooden and non-wooden setting, suggesting that substantial restorative effects of a wooden desktop are unlikely, and that higher wood coverage is needed to increase the chances of observing restorative effects.
Selenium Uptake, Transport, Metabolism, Reutilization, and Biofortification in Rice
Authors: Zhang Lianhe , Chu Chengcai 
Published: June 2022

AbstractSelenium (Se) is an essential trace element for humans and other animals. The human body mainly acquires Se from plant foods, especially cereal grains. Rice is the staple food for more than half of the world’s population. Increasing the Se concentration of rice grains can increase the average human dietary Se intake. This review summarizes recent advances in the molecular mechanisms of Se uptake, transport, subcellular distribution, retranslocation, volatilization, and Se-containing protein degradation in plants, especially rice. The strategies for improving Se concentration in rice grains by increasing Se accumulation, reducing Se volatilization, and optimizing Se form were proposed, which provide new insight into Se biofortification in rice by improving the utilization efficiency of Se.
Digging deep—implementation, standardisation and interpretation of a total oxidisable precursor (TOP) assay within the regulatory context of per- and polyfluoroalkyl substances (PFASs) in soil
Authors: Göckener Bernd , Lange Frank Thomas , Lesmeister Lukas , Gökçe Emine , Dahme Hans Ulrich , Bandow Nicole , Biegel-Engler Annegret 
Published: June 2022

AbstractOver the past decades, thousands of different per- and polyfluoroalkyl substances (PFASs) have been produced and applied in various industrial processes and consumer products. Their structural diversity has reached a level that cannot be covered by classical target screening methods for individual compounds. Large-scale contaminations of soil, however, require the need to adapt new analytical methods that can describe a contamination more comprehensively. While sum parameters such as the total oxidisable precursor (TOP) assay have been developed in the past years, they are not yet applied in the regulatory context of PFASs.In this commentary, we provide an overview on different approaches of the TOP assay as well as its benefits and disadvantages to other sum parameters for PFASs in soil samples. Furthermore, we elaborate its opportunities and its challenges that need to be tackled to implement the TOP assay as a regulatory tool. With several different approaches of the TOP assay being available, a sound and standardised method needs to be agreed upon and more research is necessary to better describe the method. Although the complexity of PFAS contaminations in soil cannot be fully covered by any analytical method alone, the TOP assay can provide valuable data to detect and characterise soil contamination as an inventory for subsequent remediation measures. Therefore, the TOP assay should be implemented as a useful tool both in research and in the regulatory context of PFASs.
Elucidating gene expression patterns across multiple biological contexts through a large-scale investigation of transcriptomic datasets
Authors: Figueiredo Rebeca Queiroz , del Ser Sara Díaz , Raschka Tamara , Hofmann-Apitius Martin , Kodamullil Alpha Tom , Mubeen Sarah , Domingo-Fernández Daniel 
Published: June 2022

AbstractDistinct gene expression patterns within cells are foundational for the diversity of functions and unique characteristics observed in specific contexts, such as human tissues and cell types. Though some biological processes commonly occur across contexts, by harnessing the vast amounts of available gene expression data, we can decipher the processes that are unique to a specific context. Therefore, with the goal of developing a portrait of context-specific patterns to better elucidate how they govern distinct biological processes, this work presents a large-scale exploration of transcriptomic signatures across three different contexts (i.e., tissues, cell types, and cell lines) by leveraging over 600 gene expression datasets categorized into 98 subcontexts. The strongest pairwise correlations between genes from these subcontexts are used for the construction of co-expression networks. Using a network-based approach, we then pinpoint patterns that are unique and common across these subcontexts. First, we focused on patterns at the level of individual nodes and evaluated their functional roles using a human protein–protein interactome as a referential network. Next, within each context, we systematically overlaid the co-expression networks to identify specific and shared correlations as well as relations already described in scientific literature. Additionally, in a pathway-level analysis, we overlaid node and edge sets from co-expression networks against pathway knowledge to identify biological processes that are related to specific subcontexts or groups of them. Finally, we have released our data and scripts athttps://zenodo.org/record/5831786andhttps://github.com/ContNeXt/, respectively and developed ContNeXt (https://contnext.scai.fraunhofer.de/), a web application to explore the networks generated in this work.
Long-term time trends in reactivated herpes simplex infections and treatment in Sweden
Authors: Lopatko Lindman Karin , Lockman-Lundgren Judith , Weidung Bodil , Olsson Jan , Elgh Fredrik , Lövheim Hugo 
Published: June 2022

Abstract
Background
Our aim was to describe the annual prevalence of herpes simplex virus (HSV) reactivation in relation to solar ultraviolet (UV) radiation and antiviral drug use in the Swedish adult population.

Methods
The study comprised 2879 anti-HSV-1 immunoglobulin (Ig) G positive subjects from five different cohorts who had donated serum from 1988 to 2010. The sera were analyzed for anti-HSV IgM using enzyme-linked immunosorbent assay. Associations between the presence of anti-HSV IgM antibodies, the apolipoprotein E ε4 allele and the serum sampling year were assessed by logistic regression. Seasonality of anti-HSV IgM was evaluated in a UV radiation model.
Data of antiviral drugs for the entire Swedish population were compiled from two different nationwide databases: the Swedish Prescribed Drug Register and the Swedish Association of the Pharmaceutical Industry.

Results
Cross-sectional and longitudinal analyses indicated that the prevalence of anti-HSV IgM antibodies declined between 1988 and 2010 (odds ratio [OR] = 0.912, p < .001), while the total annual use of antiviral drugs in Sweden gradually increased from 1984 to 2017. Higher UV radiation was associated with higher prevalence of anti-HSV IgM antibodies (OR = 1.071, p = .043).

Conclusion
The declining time trend of HSV reactivation in a Swedish cohort coincides with a steady increase of antiviral drug use in the Swedish general population.
Association between pre-pregnancy body mass index and gestational weight gain on pregnancy outcomes: a cohort study in Indonesian pregnant women
Authors: Aji Arif Sabta , Lipoeto Nur Indrawaty , Yusrawati Yusrawati , Malik Safarina G. , Kusmayanti Nur Aini , Susanto Isman , Majidah Nur Mukhlishoh , Nurunniyah Siti , Alfiana Ratih Devi , Wahyuningsih Wahyuningsih , Vimaleswaran Karani S. 
Published: June 2022

Abstract
Background
Pre-pregnancy BMI (PP BMI) and gestational weight gain (GWG) are prominent anthropometric indicators for maternal nutritional status and are related to an increased risk of adverse pregnancy outcomes. This study aimed to determine the factors affecting total GWG, PP BMI and pregnancy outcomes among pregnant women in West Sumatra, Indonesia.

Methods
This observational analysis was conducted among healthy women in the Vitamin D Pregnant Mother (VDPM) cohort study. A total of 195 pregnant women and their newborn babies were enrolled, and information regarding their socio-demographic characteristics, obstetric history, dietary intake and anthropometric data were assessed through direct interviews. Furthermore, the Institute of Medicine (IOM) 2009 guidelines were used to obtain the total GWG.

Results
PP BMI was used to categorise the 195 pregnant women as overweight/obese (43.1%), normal (46.7%) and underweight (10.2%). There were 53.3%, 34.4% and 12.3% of women who had inadequate, adequate and excessive GWG, respectively. The multinomial logistic regression model indicated that overweight or obese women at the pre-pregnancy stage were 4.09 times more likely to have an excessive rate of GWG (AOR = 4.09, 95% CI: 1.38–12.12, p = 0.011) than those whose weight was normal. Furthermore, women with excessive GWG were 27.11 times more likely to have a baby with macrosomia (AOR = 27.11, 95% CI: 2.99–245.14) (p = 0.001) and those with inadequate GWG were 9.6 times more likely to give birth to a baby with low birth weight (LBW) (AOR = 9.60, 95% CI; 0.88–105.2) (p = 0.002).

Conclusions
This study demonstrates that the malnutrition status prior to pregnancy and inadequate or excessive GWG status during pregnancy as significant risk factors for developing adverse pregnancy outcomes. These findings highlight the importance of providing information, preconception counselling and health education on weight management for healthy pregnancies.
Questionnaire-based computational screening of adult ADHD
Authors: Trognon Arthur , Richard Manon 
Published: June 2022

Abstract
Background
ADHD is classically seen as a childhood disease, although it persists in one out of two cases in adults. The diagnosis is based on a long and multidisciplinary process, involving different health professionals, leading to an under-diagnosis of adult ADHD individuals. We therefore present a psychometric screening scale for the identification of adult ADHD which could be used both in clinical and experimental settings.

Method
We designed the scale from the DSM-5 and administered it to n = 110 control individuals and n = 110 ADHD individuals. The number of items was reduced using multiple regression procedures. We then performed factorial analyses and a machine learning assessment of the predictive power of the scale in comparison with other clinical scales measuring common ADHD comorbidities.

Results
Internal consistency coefficients were calculated satisfactorily for TRAQ10, with Cronbach’s alpha measured at .9. The 2-factor model tested was confirmed, a high correlation between the items and their belonging factor. Finally, a machine-learning analysis showed that classification algorithms could identify subjects’ group membership with high accuracy, statistically superior to the performances obtained using comorbidity scales.

Conclusions
The scale showed sufficient performance for its use in clinical and experimental settings for hypothesis testing or screening purpose, although its generalizability is limited by the age and gender biases present in the data analyzed.
Relationship of cash transfers with risk of overweight and obesity in children and adults: a systematic review
Authors: Semba Richard D. , Manley James , Rosman Lori , Rahman Nihaal , Bloem Martin W. 
Published: June 2022

AbstractBackgroundCash transfer (CT) programs are an important type of social protection meant to reduce poverty. Whether CT programs increase the risk of overweight and obesity is unclear. The objective was to characterize the relationship between CT programs and the risk of overweight and obesity in children and adults.MethodsWe searched articles in PubMed, Embase, Cochrane, EconLit, Global Health, CINAHL Plus, IBSS, Health & Medical Collection, Scopus, Web of Science, and WHO Global Index Medicus in August 2021. Studies involving CT as the intervention, a control group, body mass index, overweight, or obesity as an outcome, and sample size > 300 were included. The Newcastle–Ottawa Scale was used for quality assessment.ResultsOf 2355 articles identified, 20 met the inclusion criteria. Because of marked heterogeneity in methodology, a narrative synthesis was used to present results. Thirteen of the studies reported that CT programs were associated with a significantly lower risk of overweight and obesity, eight studies showed no significant association, and one study reported a significantly increased risk of obesity in women. Quality assessment showed that most studies lacked sample size and power calculations, validation of exposure, descriptions of non-respondents or those lost to follow-up, and blinded outcome assessment.ConclusionsOverall, the studies were suggestive that CT programs either have no impact or decrease the risk of overweight and/or obesity in children, adolescents, and adults, but no firm conclusions can be drawn from the available evidence. This review demonstrated limitations in the available studies of CT programs and overweight/obesity.
The dilemma of 12/14F ureteral access sheath (UAS) usage: a case control study
Authors: Ozimek Tomasz , Wiessmeyer Judith R. , Struck Julian P. , Roesch Marie C. , Gilbert Nils , Laturnus Jan M. , Merseburger Axel S. , Kramer Mario W. 
Published: June 2022

Abstract
Background
The insertion of a ureteral access sheath (UAS) is a frequent procedure during flexible ureteroscopy (fURS) to facilitate kidney stone treatment. The aim of this study was to investigate the influence of 12/14 French (F) UAS on fURS outcomes.

Methods
We performed a retrospective monocentric analysis of fURS procedures conducted at the Department of Urology (University Hospital Schleswig–Holstein, Lübeck, Germany) for kidney stone treatment via lithotripsy or basket stone retrieval between September 2013 and June 2017. Uni- and multivariate analyses were done with the help of RStudio (Version 1.0.136) software.

Results
In total, 283 consecutive fURS were analyzed. UAS was applied in 98 cases (34.63%). The insertion of UAS was preferred in cases with multiple kidney stones and larger median maximal stone diameter (p < 0.05). UAS usage correlated with elevated radiation exposure in seconds (94 vs. 61; p < 0.0001), prolonged operation time in minutes (99 vs. 66, p < 0.0001), length of hospital stay over 48 h (LOS, 22.49% vs. 10.81%; p = 0.015), more frequent postoperative systemic inflammatory response syndrome (SIRS, 13.27% vs. 4.32%; p = 0.013) and lower postoperative stone-free rates (60.20% vs. 78.92%; p = 0.0013). Moreover, we conducted uni- and multivariate subgroup analysis for cases with multiple kidney stones (≥ 2) and comparable stone burden; UAS was inserted in 48.3% of these cases (71/147). On multivariate logistic regression, UAS insertion was statistically associated with prolonged operation time in minutes (101 vs. 77; p = 0.004). No statistical differences regarding radiation exposure, stone-free rates, postoperative SIRS rates or LOS were noted between UAS and non-UAS patients with multiple kidney stones of similar size (p > 0.05).

Conclusions
12/14F UAS does not seem to improve overall outcomes in fURS for kidney stones. In patients with multiple kidney stones it may be associated with elevated operation time without a clear benefit in terms of improved stone-free status or reduced perioperative complication rate. Further prospective randomized studies to specify the indications for UAS usage are urgently needed.
Fluoroscopy-guided trans-urethral exchange of double-J ureteral stents
Authors: Kwak JungWon , Cho Sung Bum 
Published: June 2022

Abstract
Background
For patients with malignant ureteral obstruction or stricture who require long-term internal drainage, plastic double-J stents (DJ stents) represent the mainstay of therapeutic strategies. DJ stents should be replaced at least once every 6 months to avoid infection or obstruction. Although DJ stents are generally replaced under cystoscopy, successful fluoroscopy-guided retrograde replacement of DJ stents in the interventional suite has been described in the literature.

Methods
Between April 2004 and May 2020, we exchanged 143 DJ stents in 19 male and 22 female patients under fluoroscopic guidance using Nelaton catheters, snare catheters, and 8F DJ stents. All procedures were performed with patients under sedation and local anesthesia. There were 39 patients with malignant ureteral obstruction and two patients with benign ureteral strictures. This study was approved by the Institutional Review Board. Technical success, clinical success, complications, procedure time, and mean interval between two procedures were retrospectively reviewed, and the factors affecting the success rate of the procedure were analyzed.

Results
Obstruction was detected at the abdominal ureter in 4 patients, pelvic ureter in 29 patients, and intravesical ureter in 8 patients. Twenty-six patients underwent two or more sessions of the procedures, whereas 15 patients underwent single-session procedures. Total 34 outpatient-based procedures and 109 inpatient-based procedures were performed. Technical success and clinical success were achieved in 94.4% (135/143) and 93.3% (126/135) procedures, respectively. Mean procedure time was 21.5 min (range 9–192 min). Mean procedure interval was 101.8 days (range 5–306 days). Technical success was negatively affected by male sex and obstruction at the pelvic ureter and was positively affected by previous successful exchange. Left-sided ureteral stent placement and old age negatively influenced clinical success. Septic shock occurred in one patient and was treated with antibiotics.

Conclusion
Fluoroscopy-guided trans-urethral exchange of DJ stents is an effective and less painful procedure.