bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into the Effect of the Adsorption Preference of Additives on the Anisotropic Growth of ZSM‐5 Zeolite
Authors: Shi Jing , Du Yujue , He Wanren , Zhao Guoliang , Qin Yucai , Song Lijuan , Hu Jun , Guan Yong , Zhu Junfa , Wang Chuanming , Teng Jiawei , Xie Zaiku 
Published: August 2022

AbstractZeolite morphology plays a crucial role in affecting catalytic performance, while is persistently challenging to tailor through crystal anisotropic growth. It has been recognized that specific additives can be introduced into the synthesis of zeolites to achieve anisotropic growth, however their role and the underlying mechanism are not well understood. Herein, the effect of eight specific additives on the anisotropic growth of the ZSM‐5 zeolite is unveiled within the framework of crystallization engineering. Either an inhibition effect or a promotion effect is revealed for each additive according to the crystallization kinetics. The adsorption preference of typical additives on different surfaces was demonstrated by total internal reflection fluorescence microscopy (TIRFM) and transmission X‐ray microscopy (TXM) together with 3D reconstruction. The calculated adsorption energy difference between MFI [100]/[101] and [010] surfaces was proposed as a key descriptor to estimate the possible morphology induced by additive. ZSM‐5 zeolites varying from sphere‐like, plate‐like to noodle‐like morphology could be synthesized by employing specific additives with increasing adsorption strength difference on distinct surfaces.
Temperature‐Controlled Selective Mono‐ vs. Di‐ortho‐Arylation for the Synthesis of Arylhydrazine Derivatives
Authors: Gulia Nurbey , Fornalski Jarosław , Gumienna Adrianna , Ambroziak Małgorzata , Szafert Sławomir 
Published: August 2022

AbstractA method of palladium‐catalyzed C−H arylation assisted with a 3,4,4‐trimethylpyrazol‐5‐on directing group, selectively providing mono‐ and di‐ortho‐arylated products is reported. Steric hindrance appearing between the directing group and the already introduced aryl substituent enables control of mono‐ vs. diarylation selectivity by the temperature of the reaction. Taking advantage of this, a series of monosubstituted and disubstituted derivatives were obtained in good yields. Moreover, unsymmetrical double‐arylation in a one‐pot procedure was developed to give corresponding products in reasonable yields. Additionally, synthesis and X‐ray study of intermediate palladium metallacycles of both, the first and second arylation reactions, were conducted. X‐ray structure comparison emphasizes the geometrical differences that were consistent with the observed reactivity. Finally, decarboxylative cleavage of the pyrazolone directing group under mild conditions gave synthetically useful hydrazones. The presented solution opens the alternative synthetic way to such ortho arylated derivatives of arylhydrazines.
Formation of a CoMn‐Layered Double Hydroxide/Graphite Supercapacitor by a Single Electrochemical Step
Authors: Roy Atanu , Schoetz Theresa , Gordon Leo W. , Yen Hung‐Ju , Hao Qingli , Mandler Daniel 
Published: August 2022

AbstractHybrid electric storage systems that combine capacitive and faradaic materials need to be well designed to benefit from the advantages of batteries and supercapacitors. The ultimate capacitive material is graphite (GR), yet high capacitance is usually not achieved due to restacking of its sheets. Therefore, an appealing approach to achieve high power and energy systems is to embed a faradaic 2D material in between the graphite sheets. Here, a simple one‐step approach was developed, whereby a faradaic material [layered double hydroxide (LDH)] was electrochemically formed inside electrochemically exfoliated graphite. Specifically, GR was exfoliated under negative potentials by CoII and, in the presence of MnII, formed GR‐CoMn‐LDH, which exhibited a high areal capacitance and energy density. The high areal capacitance was attributed to the exfoliation of the graphite at very negative potentials to form a 3D foam‐like structure driven by hydrogen evolution as well as the deposition of CoMn‐LDH due to hydroxide ion generation inside the GR sheets. The ratio between the CoII and MnII in the CoMn‐LDH was optimized and analyzed, and the electrochemical performance was studied. Analysis of a cross‐section of the GR‐CoMn‐LDH confirmed the deposition of LDH inside the GR layers. The areal capacitance of the electrode was 186 mF cm−2 at a scan rate of 2 mV s−1. Finally, an asymmetric supercapacitor was assembled with GR‐CoMn‐LDH and exfoliated graphite as the positive and negative electrodes, respectively, yielding an energy density of 96.1 μWh cm−3 and a power density of 5 mW cm−3.
Weight loss in a cardiovascular trial population identifies people at future risk of dementia
Authors: van der Veere Pieter , Hammami Imen , Buck Georgina , Greenland Melanie , Offer Alison , Nunn Michelle , Whiteley William , Bulbulia Richard , Collins Rory , Armitage Jane , Mafham Marion , Parish Sarah ,   the Heart Protection Study Collaborative Group
Published: August 2022

AbstractIntroductionPopulations at increased risk of dementia need to be identified for well‐powered trials of preventive interventions. Weight loss, which often occurs in pre‐clinical dementia, could identify a population at sufficiently high dementia risk.MethodsIn 12,975 survivors in the Heart Protection Study statin trial of people with, or at high risk of, cardiovascular disease, the association of weight change over 5 years during the trial with post‐trial dementia recorded in electronic hospital admission and death records (n = 784) was assessed, after adjustment for age, sex, treatment allocation, and deprivation measures.ResultsAmong the 60% without substantial weight gain (≤2 kg weight gain), each 1 kg weight loss was associated with a risk ratio for dementia of 1.04 (95% confidence interval, 1.02–1.07). Weight loss ≥4 kg and cognitive function below the mean identified participants aged ≥67 years with a 13% 10‐year dementia risk.DiscussionThe combination of weight loss and high vascular risk identified individuals at high risk of dementia who could be recruited to dementia prevention trials.
Efficient autonomous feedback controller parameter design considering robust stability for galvanometer scanner
Authors: Kuroda Eitaro , Maeda Yoshihiro , Iwasaki Makoto 
Published: August 2022

AbstractRobust stable feedback (FB) controller design against plant perturbation is crucial for industrial servo systems. However, since the controller parameter design generally requires expert skills and/or considerable labor by engineers, an autonomous controller design technology would be promising. This paper presents an efficient autonomous design method that optimizes the parameters of a cascade structure FB controller to achieve robust stabilization. Conventionally, robust stabilization is realized by imposing stability constraints on all the perturbed plant model sets in a parameter optimization problem. As a result, the design time would be much longer owing to the complicated optimization problem. The proposed method makes the parameter optimization considering robust stability more efficient than the conventional method, by simplifying the stability constraint definition and optimizing the specified circle radius for the stability constraint based on a bisection method. The effectiveness of the proposed method is evaluated through an example FB controller design for a laboratory galvanometer scanner.
A study of odor reproduction using multi‐component olfactory display
Authors: Iseki Masaaki , Prasetyawan Dani , Yokoshiki Yasufumi , Nakamoto Takamichi 
Published: August 2022

AbstractA sensory test experiment (triangle difference test) was conducted using the 20‐component olfactory display to confirm odor reproduction based on odor components. The essential oils used were lemon, palmarosa, carrot seed, elemi, lavender, cypress and mentha arvensis. Each one was selected from seven essential oil categories. The sensory test reveals that it was difficult to distinguish between the reproduced odor and the target one. Thus, the odor reproduction by olfactory display based on odor components was generally possible. Furthermore, we found that the participants used its features or intensities as clues to distinguish between the blended odor and the target one from a survey of the free comments on the questionnaire sheets.
Effects of homoarginine supplementation on heart and skeletal muscle of rats with heart failure with preserved ejection fraction
Authors: Büttner Petra , Adams Volker , Werner Sarah , Ossmann Susann , Besler Christian , Schwedhelm Edzard , Thiele Holger 
Published: August 2022

AbstractAimHeart failure with preserved ejection fraction (HFpEF) is associated with left ventricular stiffness, impaired diastolic relaxation, and severe exercise intolerance. Decreased homoarginine (hArg) levels are an independent predictor of mortality in cardiovascular disease and correlate with impaired exercise performance. We recently reported alterations in arginine, hArg, and related amino acids in obese ZSF1 rats (O‐ZSF1), with a HFpEF phenotype. Although low hArg is associated with diastolic dysfunction in humans, potential effects of hArg supplementation were not tested yet.Methods and resultsAt an age of 6 weeks, 12 O‐ZSF1 were randomized into two groups: (1) O‐ZSF1 rats supplemented with hArg in their drinking water (sO‐ZSF1) or (2) O‐ZSF1 rats receiving no hArg supplementation (O‐ZSF1). At an age of 32 weeks, effects of primary prevention by hArg supplementation on echocardiographic, histological, and functional parameters of heart and skeletal muscle were determined. Lean ZSF1 rats (L‐ZSF1) served as controls. hArg supplementation did not prevent impairment of diastolic relaxation (E/e′: O‐ZSF1 21 ± 3 vs. sO‐ZSF1 22 ± 3, P = 0.954, L‐ZSF1 18 ± 5) but resulted in more cardiac fibrosis (histological collagen staining: +57% in sO‐ZSF1 vs. O‐ZSF1, P = 0.027) and increased collagen gene expression (Col1a1: +48% in sO‐ZSF1 vs. O‐ZSF1, P = 0.026). In contrary, right ventricular function was preserved by hArg supplementation (TAPSE (mm): O‐ZSF1 1.2 ± 0.3 vs. sO‐ZSF1 1.7 ± 0.3, P = 0.020, L‐ZSF1 1.8 ± 0.4). Musculus soleus maximal specific muscle force (N/cm2) in O‐ZSF1 (30.4 ± 0.8) and sO‐ZSF1 (31.9 ± 0.9) was comparable but significantly reduced compared with L‐ZSF1 (36.4 ± 0.7; both P < 0.05). Maximal absolute muscle force (g) (O‐ZSF1: 177.6 ± 7.8, sO‐ZSF1: 187.8 ± 5.0, L‐ZSF1: 181.5 ± 7.9, all P > 0.05) and cross‐sectional fibre area (arbitrary units) (O‐ZSF1: 1697 ± 57, sO‐ZSF1: 1965 ± 121, L‐ZSF1: 1691 ± 104, all P > 0.05) were not altered.ConclusionsPreservation of physiological hArg level in HFpEF may not be suited to prevent alterations in left ventricular and skeletal muscle function and structure. However, hArg supplementation may be beneficial for right ventricular function especially in pulmonary hypertension in HFpEF. We may speculate that clinically observed decreased hArg level are not the cause but the consequence of a yet unrecognized pathomechanism that underpins HFpEF.
SARS‐CoV‐2‐related Multisystem Inflammatory Syndrome in Adult complicated by myocarditis and cardiogenic shock
Authors: De Smet M.A.J. , Fierens J. , Vanhulle L. , Vande Weygaerde Y. , Malfait T.L.A. , Devos D. , Haerynck F. , Gevaert S. 
Published: August 2022

AbstractMultisystem Inflammatory Syndrome in Adult (MIS‐A) is a rare COVID‐19 complication, presenting as fever with laboratory evidence of inflammation, severe illness requiring hospitalization and multisystem organ involvement. We report on a 25‐year‐old man presenting with fever, rash, abdominal pain, diarrhoea and vomiting following prior asymptomatic COVID‐19 infection. He developed refractory shock and type 1 respiratory insufficiency requiring mechanical ventilation. Diagnostic testing revealed significant inflammation, anemia, thrombocytopenia, acute kidney injury, hepatosplenomegaly, colitis, lymphadenopathy and myocarditis necessitating inotropy. Ventilatory, vasopressor and inotropic support was weaned following pulse corticosteroids and intravenous immunoglobulins. Heart failure therapy was started. Short‐term follow‐up shows resolution of inflammation and cardiac dysfunction.
Magnetic ion‐imprinted microspheres for the removal of heavy metal ions from aqueous solution
Authors: Zhao Zhonghua , Zou Xinquan , Zhao Yu , Shi Jinshuo , Huang Yicheng , Wang Jikui 
Published: August 2022

AbstractMagnetic ion‐imprinted microspheres (IIM) with core‐shell structure were successfully prepared by reverse emulsion polymerization and applied to adsorb heavy metal ions from sewage. The semi‐interpenetrating polymer network composed of cross‐linked polyacrylamide (PAM) and linear chitosan (CTS) was used as the microgel shell of microspheres, which can not only fully retain the active sites of CTS but also tightly encapsulate magnetic particle nuclei. In addition, ion imprinting technology was used to further improve the adsorption capacity. In this study, the effects of PAM to CTS ratio on the thermal stability, magnetic properties, and microstructure of microspheres were investigated. Adsorption studies showed that IIM exhibited excellent selective adsorption of Cu(II), and the effects of initial concentration of metal ions, adsorption time, adsorbent dosage, pH, ionic strength, and cycle times on adsorption of Cu(II) by IIM‐2 were also studied. In addition, it was revealed that pseudo‐second‐order kinetic model and Langmuir isotherm model could better simulate the adsorption kinetic and isotherm of IIM‐2 for Cu(II), respectively. At 30°C and pH 5.0, the theoretical maximum adsorption capacities for Cu(II) by IIM‐2 were 151.13 mg/g. X‐ray photoelectron spectroscopy and Zeta potential study showed that the adsorption mechanism of IIM‐2 was a combination of electrostatic interaction and ion exchange.
CCR7 alterations associated with inferior outcome of adult T‐cell leukemia/lymphoma under mogamulizumab treatment
Authors: Sakamoto Yuma , Ishida Takashi , Masaki Ayako , Murase Takayuki , Ohtsuka Eiichi , Takeshita Morishige , Muto Reiji , Iwasaki Hiromi , Ito Asahi , Kusumoto Shigeru , Nakano Nobuaki , Tokunaga Masahito , Yonekura Kentaro , Tashiro Yukie , Iida Shinsuke , Utsunomiya Atae , Ueda Ryuzo , Inagaki Hiroshi 
Published: August 2022

AbstractAdult T‐cell leukemia/lymphoma (ATL) patients have a very poor prognosis. The humanized anti‐CCR4 therapeutic monoclonal antibody, mogamulizumab, is a key agent for ATL treatment. Our previous integrated molecular analysis demonstrated that among all the driver genes in ATL, CCR7 gene alterations were significantly associated with clinical response to mogamulizumab. Accordingly, here we investigated the detailed clinical impact of CCR7 alterations in a larger cohort of ATL patients. These CCR7 alterations, most of which lead to C‐terminus truncations, were observed in 27 of 223 patients (12%). For patients receiving mogamulizumab but not allogeneic hematopoietic stem cell transplantation (HSCT), CCR7 alterations were significantly associated with worse survival (median survival from the first dose of mogamulizumab of 0.7 years for 12 patients with CCR7 alterations vs. 1.6 years for 72 patients without, p = 0.020). On the other hand, the presence or absence of CCR7 alterations had no significant impact on survival in the entire cohort (median overall survival of 1.4 and 1.8 years, respectively, p = 0.901), or on the survival of patients receiving allogeneic HSCT (median survival from the day of transplantation of 0.9 years for 6 patients with CCR7 alterations and 1.4 years for 48 without, p = 0.543). Multivariate analysis indicated that patients with CCR4 alterations but lacking CCR7 alterations (n = 20) had significantly better survival after receiving mogamulizumab‐containing treatments (hazard ratio for survival, 0.437, 95% confidence interval, 0.192–0.994). This study contributes to the establishment of precision medicine for ATL.
Biomarker adoption in developmental science: A data‐driven modelling of trends from 90 biomarkers across 20 years
Authors: Qian Weiqiang , Zhang Chao , Piersiak Hannah A. , Humphreys Kathryn L. , Mitchell Colter 
Published: August 2022

AbstractDevelopmental scientists have adopted numerous biomarkers in their research to better understand the biological underpinnings of development, environmental exposures, and variation in long‐term health. Yet, adoption patterns merit investigation given the substantial resources used to collect, analyse, and train to use biomarkers in research with infants and children. We document trends in use of 90 biomarkers between 2000 and 2020 from approximately 430,000 publications indexed by the Web of Science. We provide a tool for researchers to examine each of these biomarkers individually using a data‐driven approach to estimate the biomarker growth trajectory based on yearly publication number, publication growth rate, number of author affiliations, National Institutes of Health dedicated funding resources, journal impact factor, and years since the first publication. Results indicate that most biomarkers fit a “learning curve” trajectory (i.e., experience rapid growth followed by a plateau), though a small subset decline in use over time.
Reassessing the dependence between economic growth and financial conditions since 1973
Authors: Chernis Tony , Coe Patrick J. , Vahey Shaun P. 
Published: August 2022

SummaryAdrian, Boyarchenko and Giannone ((2019), ABG) adapt quantile regression (QR) methods to examine the relationship between US economic growth and financial conditions. We confirm their empirical findings, using their methodology and their pre‐2016 sample. Mindful of the importance of the Covid‐19 pandemic, we extend the sample to 2021Q3 and find attenuation of the key estimated coefficients using ABG's empirical methods. Given the pandemic observations, we provide robust QR analysis of dependence based on ranked data and explain the relationship with extant copula modelling methods.
Three‐dimensional speckle tracking echocardiography to evaluate left ventricular function in patients with acute ST‐segment elevation myocardial infarction after percutaneous coronary intervention following Tongxinluo treatment
Authors: Qin Wenjuan , Tian Ruimeng , Feng Jia , Zhai Zijing , Wang Zhen , Huang Lei , Lu Guilin , Dong Shanshan 
Published: August 2022

AbstractObjectiveBying comparing the correlation between three‐dimensional speckle tracking echocardiography (3D‐STE) and troponin I (cTn I), three‐dimensional left ventricular ejection fraction (3D‐LVEF), to explore the 3D‐STE to evaluate the left ventricle of patients with acute ST‐segment elevation myocardial infarction (AMI) after percutaneous coronary intervention (PCI) following routine treatment with Tongxinluo drugs.MethodsAltogether, 61 patients with AMI and 30 healthy adults were selected, and the patients were divided into the routine group and the Tongxinluo group. The serum creatine kinase isoenzyme (CK‐MB) and troponin I (cTn I) levels were detected in all patients after admission. All patients underwent PCI, and routine echocardiography and 3D‐STE assessments were performed for each group 72 h after PCI and 12 months after PCI to obtain the following left ventricular‐related functional parameters: left ventricular end‐diastolic diameter (LVEDD), end‐ventricular septal end‐diastolic thickness (IVSD), left ventricular posterior wall end‐diastolic thickness (LVPWD), left ventricular short axis shortening fraction (LVFS), Simpson's left ventricular ejection fraction (Simpson's LVEF), three‐dimensional left ventricular ejection fraction (3D‐LVEF), global longitudinal strain (GLS), global circumferential strain (GCS), left ventricular twist angle (LVtw), Torsion (Tor), peak strain dispersion (PSD), and myocardial comprehensive index (MCI). The same parameters were collected in the control group, the results were compared. The correlation analysis between 3D‐STE parameters and 3D‐LVE, cTn I was performed. A total of 10 individuals were selected for repeatability testing.ResultsCompared with the control group, the LVFS, LVEF (Simpson), 3D‐LVEF, GLS, GCS, LVtw, Tor, and MCI significantly decreased in patients with STEMI after PCI, while the PSD significantly increased (p < 0.05). Compared with the values 72 h after PCI, the LVEDD, LVFS, LVEF (Simpson), 3D‐LVEF, GLS, GCS, LVtw, Tor, and MCI significantly increased at 12 m after PCI, while PSD significantly decreased (p < 0.05). No significant difference was observed between the two groups at 72 h after PCI (p > 0.05). At 12 months after PCI, the LVEF, GLS, GCS, LVtw, Tor, and MCI of the Tongxinluo group were higher than those of the routine group. The PSD was significantly lower in the Tongxinluo group (p < 0.05). MCI and 3D‐LVEF, cTn I have the strongest correlation and the highest consistency, which can best reflect the changes in the left ventricular function in patients with AMI after PCI.Conclusion3D‐STE can be used to evaluate the protective effect of Tongxinluo on the left ventricular function in patients with AMI after PCI.
Release of VAMP5‐positive extracellular vesicles by retinal Müller glia in vivo
Authors: Demais Valerie , Pohl Anne , Wunderlich Kirsten A. , Pfaller Anna M. , Kaplan Lew , Barthélémy Amelie , Dittrich Robin , Puig Berta , Giebel Bernd , Hauck Stefanie M. , Pfrieger Frank W. , Grosche Antje 
Published: August 2022

AbstractCell‐cell interactions in the central nervous system are based on the release of molecules mediating signal exchange and providing structural and trophic support through vesicular exocytosis and the formation of extracellular vesicles. The specific mechanisms employed by each cell type in the brain are incompletely understood. Here, we explored the means of communication used by Müller cells, a type of radial glial cells in the retina, which forms part of the central nervous system. Using immunohistochemical, electron microscopic, and molecular analyses, we provide evidence for the release of distinct extracellular vesicles from endfeet and microvilli of retinal Müller cells in adult mice in vivo. We identify VAMP5 as a Müller cell‐specific SNARE component that is part of extracellular vesicles and responsive to ischemia, and we reveal differences between the secretomes of immunoaffinity‐purified Müller cells and neurons in vitro. Our findings suggest extracellular vesicle‐based communication as an important mediator of cellular interactions in the retina.