bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heavy long-lived coannihilation partner from inelastic Dark Matter model and its signatures at the LHC
Authors: Guo Jinhui , He Yuxuan , Liu Jia , Wang Xiao-Ping 
Published: April 2022

Abstract
The coannihilation mechanism is a well-motivated alternative to the simple thermal freeze-out mechanism, where the dark matter relic density can be obtained through the coannihilation with a partner particle of similar mass with dark matter. When the partner particle is neutral, the inelastic nature of dark matter can help it to escape the direct detection limits. In this work, we focus on the coannihilation scenario in which the annihilation cross section is dominated by the partner-partner pair annihilation. We pay special interest on the parameter space where the coannihilation partner is long-lived, which leads to displaced signatures at the collider. In such case, it opens the heavy mass parameter space for the coannihilation dark matter, comparing with those dominated by the partner-dark matter annihilation. Specifically, we study an inelastic scalar dark matter model with a specific parameter space, which realizes the domination of partner-partner pair annihilation. Then, we study two different realizations of the coannihilation partner decay and the existing constraints from the relic abundance, direct and indirect dark matter detection and the collider searches. We focus on the channel that the long-lived coannihilation partner decays to dark matter plus leptons. The high-luminosity LHC can reach good sensitivities for such heavy dark matter and coannihilation partner around 100–700 GeV.
Add-on-LUCAS2™-Reanimation am NEF Innsbruck
Authors: Schwaiger D. , Zanvettor A. , Neumayr A. , Baubin M. 
Published: April 2022

Zusammenfassung
Studienziel
Ziele sind die Verlaufsanalyse und der Vergleich mit ausschließlich manuell reanimierten Patienten sowie die Erfassung der Einflussfaktoren bei Patienten, bei denen die mechanische Thoraxkompressionshilfe Lund University Cardiac Assist System (LUCAS2TM) als Add-on-Therapie am Notarzteinsatzfahrzeug (NEF) Innsbruck verwendet wurde.

Material und Methodik
Retrospektive Verlaufsdatenanalyse von Patienten im Studienzeitraum 01.01.2014 bis 31.12.2019 des NEF Innsbruck aus dem Deutschen Reanimationsregister (GRR), bei denen LUCAS2™ nach notärztlicher Anordnung als Add-on-Therapie verwendet wurde.

Ergebnis
Bei 653 Reanimationen kam es zu 123 Add-on-LUCAS2™-Anwendungen (18,8 %). Von allen Patienten überlebten 16,2 % die ersten 30 Tage. Mithilfe der Add-on-LUCAS2TM Anwendung überlebten 7,3 % (9/123) aller Add-on-LUCAS2™-Reanimationen bzw. 1,4 % (n = 9) aller CPRs. Bei 8/9 Add-On-LUCAS2™-„30 Tage-Überlebenden“ war der Herz-Kreislauf-Stillstand (HKS) beobachtet, und eine Laien-CPR wurde durchgeführt. Als Primärrhythmus wiesen 8/9 Kammerflimmern auf.
Im Vergleich zur ausschließlich manuellen CPR wurde eine Add-on-LUCAS2™-Reanimation hoch signifikant (p < 0,001) häufiger bei jüngeren, bei männlichen Patienten, in der Öffentlichkeit, bei schockbarem Erstrhythmus und beim Transport eingesetzt sowie signifikant häufiger bei beobachteten HKS (p < 0,05).
Die 30-Tage-Mortalität bei additiver Lysetherapie betrug 100 %.

Diskussion
Durch die Verwendung der Add-on-LUCAS2™-CPR kann eine prozentuelle Erhöhung der Überlebensrate erzielt werden und erscheint somit vorteilhaft (1,4 % in dieser Studie). Durch diese kann bei Patienten mit günstigen Prognosefaktoren eine hochwertige HDM auch bei technisch aufwendiger Bergung (Drehleiter, Stiegenhaus, Transport im RTW) durchgeführt und somit ein Transport ermöglicht werden. Jedoch kommt es dabei zu einer höheren Aufnahmerate unter CPR und somit zur Verlagerung der Therapiezielentscheidung in den Schockraum.
Aktuelle Praxis der empirischen Antibiotikatherapie bei Spondylodiszitis
Authors: Lang Siegmund , Walter Nike , Neumann Carsten , Bärtl Susanne , Simon Michaela , Ehrenschwender Martin , Hitzenbichler Florian , Alt Volker , Rupp Markus 
Published: April 2022

ZusammenfassungHintergrund und FragestellungBei der pyogenen Spondylodiszitis gewinnen Infektionen mit Koagulase-negativen Staphylokokken zunehmend an Bedeutung. Eine empirische Antibiose ist insbesondere bei Patienten mit schweren oder progredienten neurologischen Ausfällen sowie hämodynamischer Instabilität und im Falle von kulturnegativen Spondylodiszitiden notwendig. Ob es in Deutschland einheitliche, an das Resistenzprofil angepasste Standards der empirische Antibotikatherapie gibt, ist unklar.Studiendesign und UntersuchungsmethodenEs wurde an deutschen Universitäts- und berufsgenossenschaftlichen Kliniken, jeweils in den Fachbereichen Orthopädie und Unfallchirurgie, eine Umfrage zur empirischen Antibiotikatherapie bei pyogener Spondylodiszitis durchgeführt. Die Umfrageergebnisse wurden auf das Resistenzprofil der Erreger von 45 Spondylodiszitispatienten, die zwischen 2013 und 2020 in unserer Klinik behandelt wurden, angewandt. Dadurch wurden potenzielle Sensibilitäts- und Resistenzraten für die angegebenen antibiotischen Therapien errechnet.ErgebnisseVon den 71 angefragten Kliniken antworteten insgesamt 44 (62,0 %). Sechzehn verschiedene Antibiotikatherapien wurden als jeweiliger Standard berichtet. Darunter wurden 14 verschiedene Kombinationstherapien als Therapiestandard angegeben. Die am häufigsten angegebenen empirischen Substanzen, nämlich Amoxicillin-Clavulansäure oder Ampicillin/Sulbactam (29,5 %) und Cephalosporine (18,2 %) zeigten in Bezug auf das zuvor veröffentliche Resistenzprofil hohe potenzielle Resistenzraten von 20,0 % bzw. 35,6 %. Die höchsten potenziellen Sensibilitätsraten wurden durch die Kombinationen Vancomycin + Ampicillin/Sulbactam (91,1 % sensible Erreger), Vancomycin + Piperacillin/Tazobactam (91,1 % sensible Erreger) und Ampicillin/Sulbactam + Teicoplanin (95,6 % sensible Erreger) erreicht. Eine dieser Kombinationen wurde von drei Kliniken (6,8 %) als Standard angegeben.SchlussfolgerungDie deutschlandweite Umfrage zur empirischen Antibiose bei pyogener Spondylodiszitis hat eine große Heterogenität der Standardtherapien ergeben. Eine Kombination aus einem Breitspektrum-β-Laktam-Antibiotikum mit einem zusätzlichen Glykopeptidantibiotikum kann sinnvoll sein.
A tailored intervention does not reduce low value MRI’s and arthroscopies in degenerative knee disease when the secular time trend is taken into account: a difference-in-difference analysis
Authors: Rietbergen T. , Marang-van de Mheen P. J. , de Graaf J. , Diercks R. L. , Janssen R. P. A. , van der Linden-van der Zwaag H. M. J. , van den Akker-van Marle M. E. , Steyerberg E. W. , Nelissen R. G. H. H. , van Bodegom-Vos L. ,   for the SMART study group, Pander P. , Hofstee D. J. , van Geenen R. C. I. , Koenraadt K. L. M. , Onderwater J. P. A. H. , Kleinlugtenbelt Y. V. , Gosens T. , Klos T. V. S. , Rijk P. C. , Dijkstra B. , Zeegers A. V. C. M. , Hoogeslag R. A. G. , Veld M. H. A. Huis in’t , Polak A. A. , Pereira N. R. Paulino , Vervest T. M. J. S. , van der Veen H. C. , Lopuhaä N. 
Published: April 2022

Abstract
Purpose
To evaluate the effectiveness of a tailored intervention to reduce low value MRIs and arthroscopies among patients ≥ 50 years with degenerative knee disease in 13 Dutch orthopaedic centers (intervention group) compared with all other Dutch orthopaedic centers (control group).

Methods
All patients with degenerative knee disease ≥ 50 years admitted to Dutch orthopaedic centers from January 2016 to December 2018 were included. The tailored intervention included participation of clinical champions, education on the Dutch Choosing Wisely recommendation for MRI’s and arthroscopies in degenerative knee disease, training of orthopaedic surgeons to manage patient expectations, performance feedback, and provision of a patient brochure. A difference-in-difference analysis was used to compare the time trend before (admitted January 2016–June 2017) and after introduction of the intervention (July 2017–December 2018) between intervention and control hospitals. Primary outcome was the monthly percentage of patients receiving a MRI or knee arthroscopy, weighted by type of hospital.

Results
136,446 patients were included, of whom 32,163 were treated in the intervention hospitals. The weighted percentage of patients receiving a MRI on average declined by 0.15% per month (β =  − 0.15, P < 0.001) and by 0.19% per month for arthroscopy (β =  − 0.19, P < 0.001). However, these changes over time did not differ between intervention and control hospitals, neither for MRI (β =  − 0.74, P = 0.228) nor arthroscopy (β = 0.13, P = 0.688).

Conclusions
The extent to which patients ≥ 50 years with degenerative knee disease received a MRI or arthroscopy declined significantly over time, but could not be attributed to the tailored intervention. This secular downward time trend may reflect anoverall focus of reducing low value care in The Netherlands.

Level of evidence
III.
Higher Order Deformed Elliptic Ruijsenaars Operators
Authors: Hallnäs Martin , Langmann Edwin , Noumi Masatoshi , Rosengren Hjalmar 
Published: April 2022

AbstractWe present four infinite families of mutually commuting difference operators which include the deformed elliptic Ruijsenaars operators. The trigonometric limit of this kind of operators was previously introduced by Feigin and Silantyev. They provide a quantum mechanical description of two kinds of relativistic quantum mechanical particles which can be identified with particles and anti-particles in an underlying quantum field theory. We give direct proofs of the commutativity of our operators and of some other fundamental properties such as kernel function identities. In particular, we give a rigorous proof of the quantum integrability of the deformed Ruijsenaars model.
The role of herbivores in shaping subtropical coral communities in warming oceans
Authors: Zarzyczny Karolina Magdalena , Watson Katie Margaret , Verduyn Clare Elizabeth , Reimer James Davis , Mezaki Takuma , Beger Maria 
Published: April 2022

AbstractTropicalization is rapidly restructuring subtropical marine communities. A key driver for tropicalization is changes in herbivory pressure that are linked with degrading ecosystem stability. Consequently, subtropical algal beds are being displaced by climate-mediated colonisation of coral communities. This process is thought to be aided by the elevated herbivory resulting from tropicalization, but the relative contribution to herbivory by different taxa is not fully understood. Evaluating herbivory pressure and its effect on coral cover and rugosity across a subtropical latitudinal gradient will help predict how these processes may change with further tropicalization and ocean warming. Herbivory pressure exerted by fishes and urchins across this subtropical latitudinal gradient remains unquantified. Using in-situ feeding observations, we quantify fish and urchin herbivory pressure at seven sites across non-accreting coral communities, and warmer accreting coral reefs in southern Japan. We then relate herbivory pressure to respective fish and urchin community structure and coral cover and rugosity. Urchin herbivory is greater on non-accreting coral communities than on true coral accreting reefs; a result which is reversed for fish herbivory. Overall, herbivory pressure is greater on accreting coral reefs than on coral non-accreting communities, but is dependent on reef characteristics as community structures differ more strongly among reefs than between regions. These factors are linked to coral cover and rugosity that differ between reefs, but not between climatic regions, further emphasising the influence of local factors on the benthic cover and the associated fish and urchin community, and thus herbivory pressure. Our findings provide a foundation for understanding how non-accreting coral communities may respond to ongoing tropicalization, given the fish and invertebrate herbivores they host.
Captive Breeding and Trichomonas gallinae Alter the Oral Microbiome of Bonelli’s Eagle Chicks
Authors: Alba Claudio , Sansano-Maestre José , Cid Vázquez María Dolores , Martínez-Herrero María del Carmen , Garijo-Toledo María Magdalena , Azami-Conesa Iris , Moraleda Fernández Virginia , Gómez-Muñoz María Teresa , Rodríguez Juan Miguel 
Published: April 2022

Abstract
Bonelli’s eagle (Aquila fasciata) is an endangered raptor species in Europe, and trichomonosis is one of the menaces affecting chicks at nest. In this paper, we attempt to describe the oral microbiome of Bonelli’s eagle nestlings and evaluate the influence of several factors, such as captivity breeding, Trichomonas gallinae infection, and the presence of lesions at the oropharynx. The core oral microbiome of Bonelli’s eagle is composed of Firmicutes, Bacteroidota, Fusobacteria and Proteobacteria as the most abundant phyla, and Megamonas and Bacteroides as the most abundant genera. None of the factors analysed showed a significant influence on alfa diversity, but beta diversity was affected for some of them. Captivity breeding exerted a high influence on the composition of the oral microbiome, with significant differences in the four most abundant phyla, with a relative increase of Proteobacteria and a decrease of the other three phyla in comparison with chicks bred at nest. Some genera were more abundant in captivity bred chicks, such as Escherichia-Shigella, Enterococcus, Lactobacillus, Corynebacterium, Clostridium and Staphylococcus, while Bacteroides, Oceanivirga, Peptostreptococcus, Gemella, Veillonella, Mycoplasma, Suttonella, Alloscardovia, Varibaculum and Campylobacter were more abundant in nest raised chicks. T. gallinae infection slightly influenced the composition of the microbiome, but chicks displaying trichomonosis lesions had a higher relative abundance of Bacteroides and Gemella, being the last one an opportunistic pathogen of abscess complications in humans. Raptor’s microbiomes are scarcely studied. This is the first study on the factors that influence the oral microbiome of Bonelli’s eagle.
EANM guideline on quality risk management for radiopharmaceuticals
Authors: Gillings Nic , Hjelstuen Olaug , Behe Martin , Decristoforo Clemens , Elsinga Philip H. , Ferrari Valentina , Kiss Oliver C. , Kolenc Petra , Koziorowski Jacek , Laverman Peter , Mindt Thomas L. , Ocak Meltem , Patt Marianne , Todde Sergio , Walte Almut 
Published: April 2022

AbstractThis document is intended as a supplement to the EANM “Guidelines on current Good Radiopharmacy Practice (cGRPP)” issued by the Radiopharmacy Committee of the EANM (Gillings et al. in EJNMMI Radiopharm Chem. 6:8, 2021). The aim of the EANM Radiopharmacy Committee is to provide a document that describes how to manage risks associated with small-scale “in-house” preparation of radiopharmaceuticals, not intended for commercial purposes or distribution.
Quantification of amyloid PET for future clinical use: a state-of-the-art review
Authors: Pemberton Hugh G. , Collij Lyduine E. , Heeman Fiona , Bollack Ariane , Shekari Mahnaz , Salvadó Gemma , Alves Isadora Lopes , Garcia David Vallez , Battle Mark , Buckley Christopher , Stephens Andrew W. , Bullich Santiago , Garibotto Valentina , Barkhof Frederik , Gispert Juan Domingo , Farrar Gill ,   on behalf of the AMYPAD consortium
Published: April 2022

AbstractAmyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer’s disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be determined in vivo using positron emission tomography (PET), for which three fluorine-18 labelled radiotracers have been approved for clinical use. In clinical practice, trained readers will categorise scans as either Aβ positive or negative, based on visual inspection. Diagnostic decisions are often based on these reads and patient selection for clinical trials is increasingly guided by amyloid status. However, tracer deposition in the grey matter as a function of amyloid load is an inherently continuous process, which is not sufficiently appreciated through binary cut-offs alone. State-of-the-art methods for amyloid PET quantification can generate tracer-independent measures of Aβ burden. Recent research has shown the ability of these quantitative measures to highlight pathological changes at the earliest stages of the AD continuum and generate more sensitive thresholds, as well as improving diagnostic confidence around established binary cut-offs. With the recent FDA approval of aducanumab and more candidate drugs on the horizon, early identification of amyloid burden using quantitative measures is critical for enrolling appropriate subjects to help establish the optimal window for therapeutic intervention and secondary prevention. In addition, quantitative amyloid measurements are used for treatment response monitoring in clinical trials. In clinical settings, large multi-centre studies have shown that amyloid PET results change both diagnosis and patient management and that quantification can accurately predict rates of cognitive decline. Whether these changes in management reflect an improvement in clinical outcomes is yet to be determined and further validation work is required to establish the utility of quantification for supporting treatment endpoint decisions. In this state-of-the-art review, several tools and measures available for amyloid PET quantification are summarised and discussed. Use of these methods is growing both clinically and in the research domain. Concurrently, there is a duty of care to the wider dementia community to increase visibility and understanding of these methods.
Quality of life of children during distraction osteogenesis: a comparison between intramedullary magnetic lengthening nails and external fixators
Authors: Hafez Mohamed , Nicolaou Nicolas , Offiah Amaka , Offorha Bright , Giles Stephen , Madan Sanjeev , Fernandes James A. 
Published: April 2022

Abstract
Background
Distraction osteogenesis is a very demanding process. For decades, external fixation was the only reliable option for gradual deformity correction. Recently, intramedullary magnetic nails have gained popularity. This research aimed to assess the quality of life in children during gradual deformity correction using intramedullary lengthening nails compared to external fixation.

Method
Prospective analysis included children who had gradual lower limb deformity correction between 2017 and 2019. Group A included children who had magnetic lengthening nails; patients in group B had external fixation devices. Child health utility 9D (CHU- 9D) and EuroQol 5D youth (EQ- 5D-Y) were used to measure the quality of life at fixed points during the distraction osteogenesis process. The results were used to calculate the utility at each milestone and the overall quality of life adjusted years (QALYs).

Results
Thirty-four children were recruited, group A had 16 patients, whilst group B had 18 patients. The average ages were 16.0 years and 14.7 years for groups A and B, respectively. Group A patients reported significantly better utility compared to group B. This was observed during all stages of treatment (P = 0.00016). QALYs were better for group A (0.44) compared to group B (0.34) (P < 0.0001).

Conclusion
The quality of life was generally better in group A compared to group B. In most patients, the health utility progressively improved throughout treatment. In the same way, QALYs were better with the lengthening nails compared to external fixators. The magnetic lengthening devices (PRECICE nails) which were used in this research were recently relabelled to restrict their applications in children; this study was conducted before these restrictions.
Development and validation of a self-administered questionnaire measuring essential knowledge in patients with rheumatoid arthritis
Authors: Rodère Malory , Pereira Bruno , Soubrier Martin , Fayet Françoise , Piperno Muriel , Pallot-Prades Béatrice , Pouplin Sophie , Baudens Guy , Cohen Jean-David , Coquerelle Pascal , Grange Laurent , Sordet Christelle , Tropé Sonia , Gossec Laure , Beauvais Catherine 
Published: April 2022

AbstractTo develop and validate a questionnaire assessing patient knowledge in rheumatoid arthritis (RA). Knowledge considered essential for patients with RA was identified through a series of Delphi rounds among rheumatologists, health professionals (HPs), patients, and then reformulated to construct the knowledge questionnaire. Cross-sectional multicenter validation was performed in 12 rheumatology departments to assess internal validity (Kuder–Richardson coefficient), external validity, acceptability, reproducibility (Lin’s concordance correlation coefficient) and sensitivity to change (difference in total score before and after patient education sessions). Associations between patient variables and knowledge levels were evaluated. RAKE (RA Knowledge questionnairE) is a self-administered 45-item questionnaire scored 0–100, with a 32-item short-form survey assessing knowledge of disease, comorbidity, pharmacological treatments, non-pharmacological treatments, self-care and adaptative skills. Of 130 patients included in the validation study, 108 were women. Acceptability was good with < 5% missing data. Internal validity coefficient was 0.90. Mean (standard deviation) long-form score was 72.8 ± 17.8, with lower scores in comorbidity and self-care and higher scores in adaptive skills. Reproducibility was good (0.86 [0.80; 0.92]). RAKE score was positively correlated with the patients’ level of education and the HPs’ opinion on the patients’ knowledge. RAKE score showed good sensitivity to change: 66.8 ± 16.4 then 83.8 ± 12.7, representing a hedges effect size of 1.14 [95% CI 0.73; 1.55]. RAKE is an updated questionnaire assessing essential knowledge for patients with RA to enhance self-management according to current guidelines and the patients’ perspective. RAKE can usefully inform patient education interventions, routine care and research.
Regional analysis of inflammation and contractile function in reperfused acute myocardial infarction by in vivo 19F cardiovascular magnetic resonance in pigs
Authors: Bönner Florian , Gastl M. , Nienhaus F. , Rothe M. , Jahn A. , Pfeiler S. , Gross U. , Schultheiss H.-P. , Ibanez B. , Kozerke S. , Szendroedi J. , Roden M. , Westenfeld R. , Schrader J. , Flögel U. , Heusch G. , Kelm M. 
Published: April 2022

AbstractInflammatory cell infiltration is central to healing after acute myocardial infarction (AMI). The relation of regional inflammation to edema, infarct size (IS), microvascular obstruction (MVO), intramyocardial hemorrhage (IMH), and regional and global LV function is not clear. Here we noninvasively characterized regional inflammation and contractile function in reperfused AMI in pigs using fluorine (19F) cardiovascular magnetic resonance (CMR). Adult anesthetized pigs underwent left anterior descending coronary artery instrumentation with either 90 min occlusion (n = 17) or without occlusion (sham, n = 5). After 3 days, in surviving animals a perfluorooctyl bromide nanoemulsion was infused intravenously to label monocytes/macrophages. At day 6, in vivo 1H-CMR was performed with cine, T2 and T2* weighted imaging, T2 and T1 mapping, perfusion and late gadolinium enhancement followed by 19F-CMR. Pigs were sacrificed for subsequent ex vivo scans and histology. Edema extent was 35 ± 8% and IS was 22 ± 6% of LV mass. Six of ten surviving AMI animals displayed both MVO and IMH (3.3 ± 1.6% and 1.9 ± 0.8% of LV mass). The 19F signal, reflecting the presence and density of monocytes/macrophages, was consistently smaller than edema volume or IS and not apparent in remote areas. The 19F signal-to-noise ratio (SNR) > 8 in the infarct border zone was associated with impaired remote systolic wall thickening. A whole heart value of 19F integral (19F SNR × milliliter) > 200 was related to initial LV remodeling independently of edema, IS, MVO, and IMH. Thus, 19F-CMR quantitatively characterizes regional inflammation after AMI and its relation to edema, IS, MVO, IMH and regional and global LV function and remodeling.