bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ABA INSENSITIVE (ABI) 4 transcription factor is stabilized by stress, ABA and phosphorylation
Authors: Maymon Tzofia , Eisner Nadav , Bar-Zvi Dudy 
Published: February 2022

SUMMARYThe Arabidopsis transcription factor ABSCISIC ACID INSENSITIVE 4 (ABI4) is a key player in the plant hormone abscisic acid (ABA) signaling pathway. ABI4 is also involved in seed development and germination, the response to abiotic stresses such as drought and salinity, control of lipid reserve mobilization in the embryo, lateral root formation, and redox control. Expression of the ABI4 gene is tightly regulated and basal expression is low. Maximal transcript levels occur during seed maturation and in the early stages of seed germination and are markedly reduced in other developmental stages. ABI4 is an unstable lowly expressed protein, resulting from tight post-transcriptional regulation. Here, we studied factors affecting the stability of the ABI4 protein using transgenic Arabidopsis plants expressing 35S::HA-FLAG-ABI4-eGFP. Despite the expression of eGFP-tagged ABI4 being driven by the highly active 35S CaMV promoter the steady-state levels of ABI4 were extremely low in the roots of seedling grown in optimal conditions. These levels were markedly enhanced upon exposure of the seedlings to abiotic stress and ABA. ABI4 is degraded rapidly by the 26S proteasome and we report on the role of phosphorylation of ABI4-serine 114 in regulating ABI4 stability. Our results indicate that ABI4 is tightly regulated both post-transcriptionally and post-translationally. Moreover, abiotic factors and plant hormones have similar effects on ABI4 transcripts and ABI4 protein levels. This double-check mechanism for controlling ABI4 reflects on its central role in plant development and cellular metabolism.SIGNIFICANCE STATEMENTWe show that stabilization of the ABI4 transcription factor by stress and hormones is mediated by phosphorylation of Serine 114 by MAP kinases. Transcription of ABI4 is also modulated by MAP kinases, suggesting that the same signals affect both transcript and protein levels, resulting in tight modulation of ABI4 activity.
Effect of channel integration quality on consumer responses within omni-channel retailing
Authors: Chen Tser Yieth , Yeh Tsai Lien , Wu Hsueh Ling , Deng Ssu 
Published: February 2022

PurposeThe aim of this research is to explore the influence of channel integration quality on consumer perception and response from the individual customer perspective.Design/methodology/approachThis study collected 517 online questionnaires from residents in Taipei (Taiwan) and Shenzhen (China) in 2020 based on quota sampling. The empirical study employed structural equation modeling.FindingsBased on the empirical results, the primary path indicated that channel-service configuration positively affected experience quality, which mainly positively affected customer engagement. The secondary path showed that channel-service configuration positively affected experience quality, which positively affected customer empowerment. Furthermore, experience quality and relationship proneness are mediating variables concerning the impact of channel integration quality on customer responses.Research limitations/implicationsThis study had time and budget limitations; thus, 517 questionnaires were collected from Taipei and Shenzhen. If the budget allows, it would be better to collect 1,000 questionnaires in total (500 from Taipei and 500 from Shenzhen).Practical implicationsRetailers should realize the core of omni-channel retailing, which is no longer concentrated on the “quantity” of channels but on consumers. When omni-channel retailers integrate online and offline channels, the retailers should try to understand what consumers want and then provide similar and diverse products and services in different channels so that consumers have more choices.Originality/valueThe novelty of this research is the investigation of the mediation effect of channel integration quality and consumer responses on retailers and consumers, and enriching current research on omni-channel retailing from the bottom-up perspective, as well as a comprehensive study on the two types of channel integration quality and two types of consumer responses.
Employability skills framework: a tripartite approach
Authors: Mahajan Renuka , Gupta Pragya , Misra Richa 
Published: February 2022

PurposeThe paper aims at examining the employability skills relevant in the unprecedented times of turbulence in businesses due to COVID-19 in the Indian context.Design/methodology/approachThe study examined the recent skills model through an extensive literature review. Exploratory factor analysis (EFA) is conducted to identify the employability skills perceived as important by multiple stakeholders. ANOVA was applied to examine the differences in perceived importance attached to these dimensions by the three stakeholders.FindingsThe ten-factorial solution was extracted based on the results of EFA The findings offer a fresh perspective on digital competencies perceived as most important to ensure successful long-term employability, followed by business fundamentals and behavioral skills.Research limitations/implicationsThe study has been able to map perceptions of employers, faculty and students based in Delhi-NCR regarding essential employability skills. It would be worthwhile to validate the proposed employability skills framework across different geographical sections of India and ascertain if the perceptions vary in the employment sector and employer size.Practical implicationsAlthough the study has put forth practical employability skills, there is a need for convergence between the business stakeholders and Higher Education Institutes (HEIs) to develop a broad skill-base for the fresh graduates. The study will prepare them for the volatile business environment.Originality/valueMany previous studies have lacked the employability skill framework in the Indian context from the multiple stakeholders' perspective. The HEIs can rethink their current employability, including the most prominent skills required in succeeding in a technology-enabled business environment transformed by the pandemic.
Pre-adolescent children's understanding of health and being healthy: a multidimensional perspective from the UK
Authors: Warburton Victoria E. , Beaumont Lee C. , Bishop Krystal C.M. 
Published: February 2022

PurposeThe authors applied a multidimensional conceptual lens that incorporated physical, emotional, social, intellectual and spiritual health dimensions to explore pre-adolescent children's understanding of health and what it means to be healthy.Design/methodology/approachForty-six children aged 9–11 years old completed a short questionnaire about their understanding of health and what it means to be healthy. Data analysis was completed through a deductive analysis applying a multidimensional conceptual lens and an inductive thematic analysis of the content of children's responses to each question.FindingsThe analysis of children's understandings of health and being healthy both revealed five common themes: Being well, physically active, fit and healthy; Healthy eating and body composition; Physical activity examples; Physical activity characteristics; and Unsure or ambiguous. Across both questions the majority of responses reflected the physical dimension of health, with only a few references to the social and emotional dimensions. There was no evidence of the intellectual or spiritual dimensions of health in children's responses to either question.Practical implicationsThe authors’ data suggest that the plateau in adolescent UK children's trajectory of understandings originates earlier in childhood, with children aged 9–11 showing a similarly limited understanding of health and being healthy as UK adolescents. Moreover, this focus on the physical dimension is narrower than previously considered as it is restricted to the movement category of this dimension only.Originality/valueThe authors’ findings have implications for the timing and focus of health education interventions for children.
Disinformation detox: teaching and learning about mis- and disinformation using socio-technical systems research perspectives
Authors: Paris Britt , Reynolds Rebecca , Marcello Gina 
Published: February 2022

PurposeThis paper aims to address some limitations in existing approaches to the study of mis- and dis-information and offers what the authors propose as a more comprehensive approach to framing and studying these issues, geared toward the undergraduate level of learner. In doing so, the authors prioritize social shaping of technology and critical informatics perspectives as lenses for explicating and understanding complex mis- and dis-information phenomena. One purpose is to offer readers an understanding of the mis- and dis-information studies landscape, and advocate for the merit of taking the given approach the authors outline.Design/methodology/approachThe paper builds upon design-based research (DBR) methods. In this paper, the authors present the actual curriculum that will be empirically researched in 2022 and beyond in a program of iterative DBR.FindingsFindings of this conceptual paper comprise a fully articulated undergraduate syllabus for a course the authors entitled, “Disinformation Detox.” The authors will iterate upon this curriculum development in ongoing situated studies conducted in undergraduate classrooms.Originality/valueThe value and originality of this article is in its contribution of the ontological “innovation” of a way of framing the mis- and dis-information knowledge domain in terms of social shaping and critical informatics theories. The authors argue that the proposed approach offers students the opportunity to cultivate a complex form of what Milner and Phillips describe as “ecological literacy” that is in keeping with the mis- and dis-information problem domain.
Managerial compensation and fixed intangible assets investment: the role of managerial ownership and firm characteristics
Authors: Adu-Ameyaw Emmanuel , Hickson Linda , Danso Albert 
Published: February 2022

PurposeThis study examines how cash and stock bonus compensations influence top executives to allocate a firm's resources to fixed intangible assets investment and the extent to which this relationship is conditional on executives' ownership, firm growth, internal cash flow and leverage.Design/methodology/approachUsing data from 213 non-financial and non-utility UK FTSE 350 firms for the period 2007–2015, generating a total of 1,748 firm-year observations, panel econometric methods are employed to test the authors’ model.FindingsThe authors observe that executives' cash bonus compensation positively impacts fixed intangible assets investment. However, executives' stock bonus compensation has a negative and significant influence on fixed intangible assets. The authors further observe that executives either cash bonus or stock bonus crucially invest more in fixed intangible assets when the firm has a growth potential. Also, both cash bonus and stock bonus executives in firms with lower internal cash flow spend less on fixed intangible assets. Similar results are also observed for those stock bonus-motivated executives with an increase in fixed intangible assets for low leverage firms but a decrease for high leverage ones.Research limitations/implicationsA key limitation of this study is its concentration on a single country (United Kingdom). Thus, future studies can expand the focus of this study by looking at it from the perspective of multiple countries.Practical implicationsThe practical relevance of the study results is that firms with high growth opportunity in fixed intangible assets activity can use more cash bonus compensation (risk-avoiding incentive) to induce corporate executives to invest more in such activity. This finding is particularly important given the increasing appetite of firms in this knowledge-based economy to create expansion through fixed intangible assets investment. That is, for firms to increase fixed intangible assets investment, this study suggests that executive cash bonus compensation cannot be ignored.Originality/valueWhile this paper builds on the classic Q theory of investment literature, it is the first – to the best of the authors’ knowledge – to explore how cash and stock bonus compensations influence top executives to allocate a firm's resources to fixed intangible assets investment and the extent to which this relationship is conditional on executives' ownership, firm growth, internal cash flow and leverage.
Development of a brand community engagement model: a service-dominant logic perspective
Authors: Haverila Kai , Haverila Matti , McLaughlin Caitlin 
Published: February 2022

Purpose
The purpose of this paper is to develop a model that examines motives as antecedents and consequences of brand community engagement (BCE) based on the recent service-dominant (S-D) logic framework, which considers the many actors involved in creating and consuming value in the context of brand communities (BCs).

Design/methodology/approach
Data were collected used an online survey and analyzed used partial least squares structural equation modeling.

Findings
The relationships and their significance were examined using S-D logic. The results indicate that motives of information, self-discovery, status enhancement and entertainment were positively and significantly related to BCE, except social integration. BCE was significantly related to relationship quality (RQ) and customer satisfaction (CS). Finally, CS had a significant positive impact on RQ.

Originality/value
The contribution stems from the incorporation of the recent iteration of S-D logic as a theoretical framework into the BC model and the assessment of the relationships in the structural model.
Fatal pediatric hyperthermia: A forensic review
Authors: Bushong Lee C. , Diao Zhu 
Published: February 2022

AbstractThis paper examines a pediatric hyperthermia homicide in which the decedent was placed into a room with only a diaper on and left unattended overnight. There were no furnishings in the room except for a 1500‐W space heater and a stroller. The following morning, emergency personnel were summoned to the residence. A caretaker said the decedent was playing normally 5 min before making the 911 call. The decedent’s initial rectal temperature was 42.2°C. Law enforcement asked how long the child had to be exposed to a high temperature in order to induce fatal hyperthermia in an empty bedroom. The scene was reconstructed using the child’s residence and the same heater. Environmental data were gathered over a 16‐h period. The thermal parameters of the room and environment were analyzed using a lumped‐element thermal model. These parameters were then fed into an adapted Gagge’s two‐node model of human thermal regulation, which provided a time‐window of exposure necessary to elicit hyperthermia, which in this case, depending on certain variables, ranged from 45 min to 4 h.
Hashish seizures in Algeria over the 2019–2020 period: The rise of potent hashish hybrids
Authors: Boumrah Yacine , Kermouche Wissam , Zarita Bouzid , Drardja El Djemai , Bouanani Sabrina 
Published: February 2022

AbstractIn Algeria, hashish is by far the most common illicit drug. This study explores Algerian hashish over a two‐year period (2019–2020). A total of 2583 hashish samples from 1707 seizures for a total quantity of 108 tons were analyzed using a validated high‐performance liquid chromatography–diode array detection method (HPLC–DAD). The yearly arithmetic mean tetrahydrocannabinol (THC) concentration shows relative stability—18.67% in 2019 and 19.03% in 2020 with an overall mean THC content of 18.87% and standard deviation of 10.99%. High‐potency hashish (THC content > 20%) is by far the most predominant type, representing almost 50% of the total Algerian hashish seizures (mean and median around 29%). The overall mean of cannabidiol (CBD) was 2.45%, and 12% of the total studied seizures were of very low CBD concentration (CBD content<1%). Three distinct hashish chemotypes were identified: Chemotype I described the traditional Moroccan hashish with THC content ranging from 0% to 16%, Chemotype II hashish included most of the seizures and characterized by THC content ranging from 16% to 30%, and Chemotype III was characterized by hashish potency higher than 30% and very low CBD content. The identified chemotypes I, II, and III were characterized in a ternary plot, and the relative contents (THC:CBD:CBN) were about 67%:29%:4%, 88%:9%:3%, and 96%:2%:2%, respectively.
The burden of illness of rheumatoid arthritis in Latin America—A systematic literature review
Authors: Papadimitropoulos Emmanuel , Brnabic Alan , Vorstenbosch Ellen , Leonardi Felice , Moyano Sebastian , Gomez Diana 
Published: February 2022

AbstractRheumatoid arthritis (RA) is a chronic autoimmune disease which, when left untreated, may result in the destruction of multiple joints and damage a wide variety of body systems, including the skin, eyes, lungs, heart, and blood vessels. The objective of this study was to conduct a systematic review of disease burden for RA in Argentina, Brazil, Colombia, Mexico, and Venezuela. PubMed/Medline, Embase, and Web of Science were searched for publications in English, Spanish, or Portuguese from 2008 through June 2018. A total of 1700 records were retrieved and 36 articles were included. The estimated prevalence of RA for these countries ranged from 0.15% (Colombia) to 2.8% (Mexico). The Global Burden of Disease initiative 2019 estimated that RA accounted for 0.13% of world disability‐adjusted life‐years. For Latin America, these figures were higher: Argentina 0.16%, Brazil 0.16%, Colombia 0.21%, Mexico 0.30%, and Venezuela 0.24%. RA has a negative impact on physical, mental, and emotional well‐being as shown by substantially lower scores on measures of quality of life (SF‐36) compared with the general population. The annual direct cost in Mexico was estimated at US$3599 per person. For patients with severe RA in Brazil these costs were approximately US$10 000. Data from other studied countries were similar. Though evidence of the full cost and impact of RA in Latin American countries is scarce and additional studies are needed, the burden of RA in these regions is significant and comparable to other parts the world.
Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock
Authors: Minteer Christopher , Morselli Marco , Meer Margarita , Cao Jian , Higgins‐Chen Albert , Lang Sabine M. , Pellegrini Matteo , Yan Qin , Levine Morgan E. 
Published: February 2022

AbstractAging is associated with dramatic changes to DNA methylation (DNAm), although the causes and consequences of such alterations are unknown. Our ability to experimentally uncover mechanisms of epigenetic aging will be greatly enhanced by our ability to study and manipulate these changes using in vitro models. However, it remains unclear whether the changes elicited by cells in culture can serve as a model of what is observed in aging tissues in vivo. To test this, we serially passaged mouse embryonic fibroblasts (MEFs) and assessed changes in DNAm at each time point via reduced representation bisulfite sequencing. By developing a measure that tracked cellular aging in vitro, we tested whether it tracked physiological aging in various mouse tissues and whether anti‐aging interventions modulate this measure. Our measure, termed CultureAGE, was shown to strongly increase with age when examined in multiple tissues (liver, lung, kidney, blood, and adipose). As a control, we confirmed that the measure was not a marker of cellular senescence, suggesting that it reflects a distinct yet progressive cellular aging phenomena that can be induced in vitro. Furthermore, we demonstrated slower epigenetic aging in animals undergoing caloric restriction and a resetting of our measure in lung and kidney fibroblasts when re‐programmed to iPSCs. Enrichment and clustering analysis implicated EED and Polycomb group (PcG) factors as potentially important chromatin regulators in translational culture aging phenotypes. Overall, this study supports the concept that physiologically relevant aging changes can be induced in vitro and used to uncover mechanistic insights into epigenetic aging.
What Drives Stock Market Underreaction to Liquidity Shocks? Evidence from Korea*
Authors: Jang Jeewon 
Published: February 2022

AbstractStock‐level liquidity shocks have a positive cross‐sectional relation to not only contemporaneous returns but also one‐month‐ahead returns in the Korean stock market, which implies that the stock market underreacts to liquidity shocks. However, the return continuation after the arrival of liquidity shocks is short‐lived and disappears in two months in Korea, unlike in the United States. The positive relation between liquidity shocks and one‐month‐ahead returns is most pronounced for illiquid stocks but not present for liquid stocks, independently of the level of investor attention. However, the effect of limited attention on the positive relation differs somewhat across alternative attention proxies and becomes insignificant after controlling for liquidity. This evidence suggests that the short‐lived underreaction to liquidity shocks in the Korean stock market is primarily driven not by inattention but by illiquidity.
Risk Aversion and the Gender Gap in the Vote for Populist Radical Right Parties
Authors: Oshri Odelia , Harsgor Liran , Itzkovitch‐Malka Reut , Tuttnauer Or 
Published: February 2022

AbstractPrevious research has established that men are more likely to vote for populist radical right parties (PRRPs) than women. This article shows how cross‐national and temporal variations in PRRPs’ electoral success interact with individuals’ risk propensity to affect this gender gap. We hypothesize that gender differences in the electoral support of PRRPs stem from disparities in risk‐taking. We conceptualize risk in terms of two components, social and electoral, and demonstrate that women are more risk‐averse regarding both. Our analysis is based on public opinion data from 14 countries (2002–16) combined with macrolevel data on PRRPs’ past parliamentary fortunes. To distinguish between the social and electoral components in risk‐taking, we use the illustrative case study of Germany. Findings demonstrate that gender differences in risk‐taking and, by implication, the differences between women's and men's responses to the electoral context are key to understanding the voting gender gap.