bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH SERVICE QUALITY DAN PATIENT SAFETY EXPECTATION TERHADAP CUSTOMER SATISFACTION DAN CUSTOMER LOYALTY PADA AIC MEDICAL CLINIC DI MASA PANDEMI COVID-19 [THE EFFECT OF SERVICE QUALITY AND PATIENT SAFETY EXPECTATION ON CUSTOMER SATISFACTION AND CUSTOMER LOYALTY ON AIC MEDICAL CLINIC DURING THE COVID-19 PANDEMIC]
Authors: Kho Ardi , Budianto Bernard , Antoni Irene 
Published: May 2022

<p>This study was conducted during the COVID-19 Pandemic when patients were afraid and avoided going to the clinic so there was a decrease in patient visits to AIC Medical. This study is to find out whether patients prefer patient safety expectations rather than service quality that affects customer satisfaction, and increases customer loyalty. This study was conducted in Jakarta involving 162 patients at AIC Medical Clinic. Data was collected by distributing questionnaires containing 40 statements using a Likert scale of 1–5 based on a non-probability sampling method with a saturation sampling technique. Data were analyzed using the PLS-based SEM method. The research results support some of the proposed models. The findings are service quality, patient safety expectations, and corporate CSR has a positive effect on customer satisfaction. Other research findings that support the relationship between service quality and customer loyalty are positive. The results show that the effect of cultural similarity on customer satisfaction is negative. The findings confirm that customer satisfaction is partial mediation of the relationship between service quality and customer loyalty.</p><p><strong>BAHASA INDONESIA ABSTRACT</strong></p><p>Penelitian ini dilakukan pada masa pandemi COVID-19 saat pasien takut dan menghindari untuk ke klinik sehingga terjadi penurunan kunjungan pasien ke AIC Medical Clinic. Penelitian ini untuk mengetahui apakah pasien lebih memilih keamanan atau <em>patient safety expectation</em> daripada <em>service quality</em> yang berpengaruh terhadap <em>customer satisfaction, </em>dan meningkat<em> customer loyalty. </em>Penelitian ini dilakukan di Jakarta dengan melibatkan 162 pasien di AIC Medical Clinic. Pengumpulan data dilakukan dengan menyebarkan kuesioner berisi 40 pernyataan dengan Skala Likert 1–5 berdasarkan metode <em>purposive sampling</em> dengan kriteria pasien yang datang di klinik saat pandemi COVID-19. Data dianalisis dengan metode SEM berbasiskan PLS. Hasil penelitian mendukung sebagian model yang diusulkan, <em>service quality, patient safety expectation</em> dan CSR perusahaan berpengaruh positif terhadap <em>customer satisfaction</em>. Temuan lain penelitian mendukung hubungan <em>service quality</em> terhadap <em>customer loyalty</em> adalah positif. Terdapat pengaruh<em> patient safety expectation </em>terhadap <em>customer satisfaction </em>lebih besar<em> </em>dibandingkan oleh pengaruh<em> service quality, </em>tetapi pengaruh <em>cultural similarity</em> terhadap <em>customer satisfaction</em> adalah negatif. Temuan mengonfirmasi mediasi <em>customer satisfaction</em> mempengaruhi <em>customer loyalty.</em></p>
Surface Groundwater Pollution Dynamics Over 2015-2020 in the Salt Drying Pond of Pademawu Subdistrict, Madura, Indonesia
Authors: Gemilang Wisnu Arya , Wisha Ulung Jantama , Mardyanto Mas Agus 
Published: May 2022

Pamekasan coastal area is the center of salt production concentrated in the Pademawu subdistrict with the ponds area of 740.96 ha. The sufficiently close distance of salt ponds to settlement areas allows several issues, such as shallow groundwater salinization. This study aimed to determine the salt pond’s degradation over five years (2015-2020) and its influence on the salinization issue in Pademawu. We compare groundwater quality parameters (conductivity, TDS, the depth of shallow surface groundwater, and salinity) surveyed in 2015 and 2020, correlated to salt pond area alterations. Over five years of measurement, it was found that conductivity declined, reaching 2779.94 µS/cm. Based on TDS deterioration, groundwater transformed from brackish to freshwater in 2020. By contrast, the depth of shallow groundwater-surface increased by almost one meter. The freshwater area also increased by 22% over five years based on conductivity classification. Groundwater quality dynamics are related to the alteration of the salt pond area. On the other hand, the significant increase in rainfall intensity, which is not beneficial for salt agriculture, results in the salt pond area deterioration, thereby declining surface groundwater salinity in Pademawu due to the less interaction between Cl and groundwater within aquifers. Although the groundwater pollution induced by seawater intrusion and salinization declined in 2020, re-organizing the distance between salt ponds and the settlement area in Pademawu is crucial to minimize further groundwater pollution.
Keywords : Dynamics; pollution; groundwater; salt agriculture; Pademawu

Copyright (c) 2022 Geosfera Indonesia and Department of Geography Education, University of Jember
This work is licensed under a Creative Commons Attribution-Share A like 4.0 International License
Performance of Soil Quality: Indicator-Based GIS Analysis of Jamuna-Dhaleshwari and Surma-Kushiyara Floodplain Regions, Bangladesh
Authors: Sarker Tanbi Tanaya , Begum Sameena , Khan Md. Shohel , Salam Mohammed Abdus , Tawsif Shehan 
Published: May 2022

Bangladesh is an agriculture based economic country formed by sediment deposition from upstream rivers. This riparian country covered with fertile soil that supports agricultural diversification. The study aimed to compare current soil quality of Jamuna-dhaleshwari (Manikganj) and Surma-kushiyara (Sylhet) floodplain physiographic regions to forecast about agricultural productivity. Soil quality was assessed through physical (soil texture and moisture), and chemical (pH, electrical conductivity (EC), salinity, soil nutrients (N, P, K), and organic matter content) indicators. A total of 36 soil samples in three different depths (0-15cm, 15-50cm, 50-100cm) from 12 sites were collected from Manikganj and Sylhet Districts. The average particle size and moisture content ratios of Manikganj: Sylhet were gravels (7.88:5.8), very coarse sand (6.85:8.53), coarse sand (7.45:13.2), medium sand (7.35:14), fine sand (6.12:16.4), very fine sand (24.3:19.9), silt (39.56:20.57), and clay (29.3:32.81), followed by, pH (7.61:6.31), and EC (0.24:0.18), respectively. The result revealed that the soil was bit alkaline for Manikganj, compared to range from alkaline to acidic in Sylhet and non-saline for both areas that was suitable for agriculture. The average concentration of nitrogen (N), phosphorous (P), potassium (K) nutrients in Manikganj and Sylhet Districts were 0.14%, 3.73 meq/100g, 0.07 µg/g; 0.16%, 3.11 meq/100g, 0.08 µg/g and organic matter were 3.65% and 4.7%, respectively. The results of nutrients in both areas indicated that nutrients were very poor but soil organic matter content was sufficient for agricultural activities. The study concluded that soil texture, pH, salinity and organic matter content in both areas were suitable for agricultural purposes, but a significant declined was found in soil moisture and nutrients quality. Finally, it was recommended that soils of Manikganj were more sustainable for agricultural activities.
Keywords : Soil quality; soil texture; organic matter; spatial distribution

Copyright (c) 2022 Geosfera Indonesia and Department of Geography Education, University of Jember
This work is licensed under a Creative Commons Attribution-Share A like 4.0 International License
MOTIVASI GENERASI MUDA DALAM MELAKUKAN USAHATANI DESA PANGKATREJO KABUPATEN LAMONGAN
Authors: Oktavia Sistri Etika , Suprapti Isdiana 
Published: May 2022

Petani dan buruh tani di Desa Pangkatrejo didominasi oleh penduduk yang berumur kisaran 45-65 tahun, pada umur tersebut petani sangat rentan dalam mengadopsi teknologi terbaru sehingga perlu adanya peran pemuda untuk melakukan usahatani. Tujuan dari penelitian ini yaitu (1) mengetahui persepsi generasi muda tentang pekerjaan pertanian (2) mengetahui faktor-faktor yang mempengaruhi motivasi generasi muda dalam melakukan usahatani (3) mengetahui hubungan antara persepsi tentang pertanian terhadap motivasi dalam melakukan usahatani. Penelitian menggunakan 42 responden yang diambil dengan purposive sampling. Data dikumpulkan dengan pengamatan, wawancara dan penyebaran kuisioner. Data dianalisis dengan regresi linear berganda dan korelasi. Persepsi pemuda tentang pekerjaan di sektor pertanian meliputi persepsi tentang pendapatan yang bernilai positif, persepsi tentang risiko usahatani yang bernilai negatif, dan persepsi tentang kenyamanan kerja bernilai negatif. Secara simultan variabel pendidikan, pengalaman berusahatani, pengaruh lingkungan sosial, pengaruh orang tua dan teknologi berpengaruh signifikan terhadap motivasi generasi muda dalam melakukan usahatani. Secara parsial variabel yang berpengaruh signifikan terhadap motivasi generasi muda dalam melakukan usahatani yaitu variabel pendidikan, pengaruh lingkungan sosial, dan teknologi. Tidak terdapat hubungan yang signifikan persepsi dengan motivasi generasi muda dalam melakukan usahatani. Saran yang bisa direkomendasikan adalah terkait faktor-faktor yang mempengaruhi motivasi. Sekolah harus mempunyai kegiatan yang memperkenalkan dunia pertanian sejak dini kepada pemuda. Penyuluhan di Desa Pangkatrejo harus lebih intensif lagi dengan cara memperkenalkan teknologi modern dan mengajak pemuda untuk gabung dalam kegiatan sosialisasi penyuluhan tentang pertanian.
Well Path Design and Optimization Using Composite Cubic Bezier Curves
Authors: Cao Jie , Sui Dan 
Published: May 2022

Summary
Well path design is a primary part of the well plan for well drilling. The main objective of well path design is to generate a continuous and smooth trajectory from a start point to a target point under various design constraints. The conventional approaches usually consist of a number of circular arcs and straight lines, representing build and turn sections and hold sections, respectively. This study presents a new methodology to generate a continuous and smooth well path trajectory with low dogleg severity (DLS) using composite Bezier curves. The trajectory consists of a number of piecewise cubic Bezier curves that satisfy C1 and/or C2 continuity conditions, meaning that the joining curves share the first and second derivatives at the joining points, respectively. The comprehensive methodology for determining the composite curve and the primary properties of the well trajectory is presented. Their advantages regarding feasibility and efficiency are demonstrated in case studies. The proposed method is also applied in a field case, where the automatically generated well path using composite Bezier curves is smoother with a smaller DLS. It can also be quickly updated if a real-time anticollision adjustment is required. The presented work has strong potential to be an efficient and automatic tool for path design and optimization in well planning.
Fabrication of covalently linked ruthenium complex onto carbon nitride nanotubes for the photocatalytic degradation of tetracycline antibiotic
Authors: Nejad Mohaddeseh Shahabi , Vakily Zahra , Mostafavi Ali , Sheibani Hassan 
Published: May 2022

Abstract
Due to the problem of direct disposal of effluents containing antibiotics to the environment and the emergence of resistant bacterial pathogens, the wastewater treatment of the pharmaceutical industry has been known as an important research background. In this study, the refinement and photodegradation ability of one of the most widely used antibiotics, “tetracycline” was investigated by ruthenium complex immobilized on the modified graphitic carbon nitride nanotubes. For this purpose, graphitic carbon nitride nanotubes (g-C3N4 NTs) were successfully synthesized by the hydrothermal method and functionalized with 1,10-Phenantroline-5,6-dione ligand during another step. Then, the functionalized g-C3N4 NTs were reinforced with immobilization of dichloro(p-cymene)ruthenium(II) dimer. The structure and morphology of the prepared photocatalyst was studied by X-ray diffraction (XRD), Fourier transform infrared (FT-IR), scanning, and transmission electron microscopy (SEM & TEM) analyses. In the following, the photocatalyst's ability to optically degrade the tetracycline antibiotics was performed in a suspension reactor equipped with a LED lamp (60 W), and effective parameters such as the amount of catalyst, and irradiation time, temperature, and pH were optimized. The results showed that the immobilization of Ru complex onto functionalized g-C3N4 NTs improved the photocatalytic activity and increased the degradation efficiencies to an amount of 43%. Furthermore, COD analysis has used the determination of the amount of mineralization and results showed that the mineralization of 10 mg/L tetracycline solution of about 90% can be performed using 20 mg of Ru (II) complex/ g-C3N4 NTs at pH = 7 after 480 min without any additive oxidant.
Periradicular repair after single- and two-visit root canal treatments using ultrasonic irrigant activation and calcium hydroxide dressing of teeth with apical periodontitis: study protocol for randomized controlled trials
Authors: Almeida Gustavo M. , Carvalho Vitor Hugo M , Silva Erika B. P. , Cançado Marco Antonio F , Barroso Leonardo S. , Queiroz Erica Lean , An Tien Li , Ribeiro Ana Paula D. , Carvalho-Junior Jacy R. , Leite Andre F. 
Published: May 2022

Abstract
Background
Traditionally, root canal treatment in teeth with apical periodontitis is performed in multiple-visits, with the use of intracanal dressing between visits, aiming to reduce microorganisms and their by-products of the root canal system prior to filling. However, in recent years, discussions have been growing about the real need for the use of intracanal dressing in these cases. The use of ultrasonic activation of the auxiliary chemical substance has increased the potential for decontamination promoted during the chemomechanical preparation of the root canal. Thus, this study is designed to explore whether the use of intracanal dressing between visits during endodontic treatment favors periradicular repair in teeth with apical periodontitis.
Methods
This is a randomized, prospective, double-blinded, controlled clinical trial designed to evaluate 3 distinct clinical approaches used during endodontic therapy. Group 1- Root canal treatment in a single-visit (RCT-SV); Group 2- Root canal treatment in two-visits with intracanal dressing (RCT-TVWD); Group 3- Root canal treatment in two-visits without intracanal dressing (RCT-TVWOD). A total of 150 adult patients ages 18 to 60, with at least one tooth diagnosed with asymptomatic apical periodontitis and periradicular lesion will be randomized and will undergo one of the types of clinical approaches during endodontic therapy. Patients' postoperative pain levels will also be recorded in periods of 24, 48, 72 hours and 7 days. Subsequently, clinical findings and long-term follow-up evaluations, with periradicular repair will be performed by periapical radiograph and cone beam computed tomography (CBCT) at 6, 12 and 24 months.
Discussion
This study will evaluate the periradicular repair of mandibular molar teeth with apical periodontitis, providing information about the efficacy, benefits and safety of performing endodontic treatment in a single- and two-visit, with and without the use of calcium hydroxide dressing. All endodontic therapy procedures will be performed under a dental operating microscope and using ultrasonic activation of auxiliary chemical substances. These results may contribute to changes in the clinical approaches adopted during endodontic therapy of teeth with apical periodontitis and reveal the potential of complementary approaches that aim to enhance the decontamination of the root canal system during the preparation stage.
Trial registration:
ClinicalTrials.gov NCT05256667. Registered on 24 February 2022
Encapsulation of Brunfelsia pauciflora microprogated shoots as a suitable conservation protocol
Authors: A Tarek A , Shaaban Shimaa A , Taha Lobna S , Mahgoub Mona H , Gabr Ahmed M.M , ibrahim awatef ibrahim 
Published: May 2022

Abstract
The current study aimed to establish an efficient in vitro propagation and conservation protocol for Brunfelsia pauciflora plant. The effect of plant growth regulators types (BAP, Kin, 2ip and NAA) and concentrations at 0.0, 1.0, and 2.0 mg/l were studied during establishment phase in comparing with hormonal-free medium. In vitro proliferated shootlets were encapsulated using various levels of sodium alginate at 1, 2 and 3% (W/V) and calcium chloride at 2.5,5 and 10 %. Regrowth ability of encapsulated explants was evaluated after conservation for 3, 5, and 7 weeks and compared with non-encapsulated buds. The findings of the current study proved that during establishment phase, applying BAP at 2.0 mg/l gave the best results during the three successive subcultures. The best treatment 2ip (2.0mg/l) + BAP (2.0mg/l) + NAA (2.0mg/l) that was considered ideal propagation protocol for shooting and rooting of Brunfelsia. Successful plant recovery from encapsulated explants using low concentrations of sodium alginate (1%) and calcium chloride at 2.5%, proved that the explants could to be survive at highest percent (100%) during conservation periods 3, 5 and 7weeks. Increasing calcium chloride to 5% with the same concentration of sodium alginate (1%) caused gradually reduced percent of survival to 53.33% with increasing conservations period (from 3 to 7weeks). It is the first paper of the application of syndetic seed technique on Brunfelsia for the shortest period conservation and successive renovation of shootlets whose genetic stabilization was evaluated by analysis of RAPD that proved that the genetic similarity ranged from 56.1 to 80%. These results were confirmed by anatomical sections made in Brunfelsia leaf blade.
Biochanin A protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/HO-1 axis and alleviates pain symptom in intervertebral disc degeneration rats
Authors: Pan Xiangxiang , Hu Sunli , Lin Jinhao , Zhang Chanqiong , Abdullah Al Mamun , Zhang Hongyuan , Jiang Zhichen , Lu Sisi , Du Jinhui , Sheng Sunren , Jin Haiming 
Published: May 2022

Abstract
Intervertebral disc degeneration (IVDD) is one of the major causes of severe back pain, but reasonable therapies are still lacking due to its complicated pathology. It has been proved that increased level of interleukin-1β (IL-1β) correlates closely with IVDD. Biochanin A (BCA) is a natural edible isoflavone owing to wide-ranging pharmacological effects such as anti-inflammatory and anti-tumor effects. Hence, we aimed to investigate the effects of BCA on rat nucleus pulposus cells (NPCs) under IL-1β stimulation in vitro and in a puncture-induced rat IVDD model in vivo. The effects of BCA on apoptosis, inflammation-related factors and extracellular matrix (ECM) metabolism were assessed in IL-1β-induced NPCs. Mechanistically, the nuclear factor-κB (NF-κB) signaling pathway and Nrf2/HO-1 (nuclear factor erythroid 2-related factor 2/heme oxygenase-1) axis were also evaluated. The results showed that BCA suppressed inflammatory mediators as well as apoptosis and ECM degradation induced by IL-1β treatment in NPCs. Moreover, molecular docking analysis indicated a great interaction energy value for interaction between BCA and Nrf2, as the mechanism study revealed that BCA may suppress the NF-κB pathway by activating Nrf2/HO-1 axis, thus inhibiting IL-1β-induced inflammation and catabolism in NPCs. Finally, in vivo study demonstrated that BCA could alleviate IVDD progression in rats and relieve associated pain symptom. Additionally, more severe ECM degradation were found in the IVDD group compared with sham group, but BCA-induced upregulation of Nrf2 reversed this pathology, consistent with in vitro results. Collectively, BCA may potentially alleviate IVDD progression and related pain, and the mechanism may relate to the activation of Nrf2/HO-1 axis.
CDK6 is upregulated and may be a potential therapeutic target in enzalutamide-resistant castration- resistant prostate cancer by bioinformatic analysis
Authors: Chen Xi , Wu Yechen , Wang Xinan , Xu Chengdang , Wang Licheng , Jian Jingang , Wu Denglong , Wu Gang 
Published: May 2022

Abstract
BackgroundAndrogen deprivation therapy (ADT) is still the first line treatment of prostate cancer (PCa). However, after a certain period of therapy, primary PCa inevitably progresses into castration-resistant PCa (CRPC). Enzalutamide (MDV3100) is an androgen receptor (AR) signal inhibitor which can delay the progression of CRPC and increase survival of patients with metastatic CRPC. However, the mechanisms involved in enzalutamide-resistant (EnzR) CRPC are still controversial. MethodsWe collected RNA-seq data of the EnzR CRPC cell line LNCaP (EnzR LNCaP) from GSE44905, GSE78201, and GSE150807. We found the hub genes from the three datasets. Then we tested the expression of the hub genes in the Cancer Genome Atlas (TCGA) database and the potential drugs that affect the hub genes. Finally, we verified the hub gene expression and drug function.ResultsFrom GSE44905, GSE78201 and GSE150807, we found 45 differently expressed genes (DEGs) between LNCaP and EnzR LNCaP. Ten hub genes were found in the protein-protein interaction (PPI) network. The hub genes expression and survival analysis were analyzed by GEPIA depend on the TCGA database. We found that cyclin-dependent kinase 6 (CDK6) was highly expressed in both the EnzR LNCaP cell and PCa patients. Ten potential small molecules could suppress CDK6 expression as per CMap findings. Finally, we found the expression of CDK6 increased in both PCa patients’ samples, CRPC cell lines and EnzR PCa cell lines. Three potential CDK6 inhibitors, namely apigenin, chrysin and fisetin, can decrease cell proliferation.ConclusionsThe study proved that CDK6 mutation may be a reason behind EnzR CRPC occurrence and suppression CDK6 expression may help treat EnzR CRPC.
HLA-G alleles impact the perinatal father-child HPV transmission
Authors: Suominen Nelli Tuulia , Roger Michel , Faucher Marie-Claude , Syrjänen Kari J , Grénman Seija E , Syrjänen Stina M , Louvanto Karolina 
Published: May 2022

Abstract
BackgroundThe host factors that influence the father-to-child human papillomavirus (HPV) transmission remain unknown. This study evaluated whether human leukocyte antigen (HLA)-G alleles are important in father-to-child HPV transmission during the perinatal period.MethodsAltogether, 134 father-newborn dyads from the Finnish Family HPV Study were included in the analyses. Oral, semen and urethral samples from the fathers were collected before the delivery, and oral samples from their offspring at delivery and postpartum at birth, day-3, at 1-, 2- and 6-month follow-up visits. HLA-G alleles were tested by direct sequencing. Unconditional logistic regression was used to determine the associations between the father-child HLA-G allele and genotype concordance and the father-child HPV prevalence and concordance at birth and during follow-up.ResultsHLA-G allele G*01:01:03 concordance was associated with father’s urethral and child’s oral high-risk (HR)-HPV concordance at birth (OR 17.00, 95%CI:1.24-232.22). Controversially at postpartum period G*01:01:03 discordance was associated with father’s urethral and child’s oral HR-HPV concordance (OR 6.67, 95%CI:1.08-40.97). HLA-G allele G*01:04:01 concordance increased the father’s oral and child’s postpartum oral any- and HR-HPV concordance, with OR 7.50 (95%CI:1.47-38.16) and OR 7.78 (95%CI:1.38-43.85), respectively. There was no association between different HLA-G genotypes and HPV concordance among the father-child dyads at birth or postpartum.ConclusionThe HLA-G allele concordance appears to impact the HPV transmission between the father and his offspring. This suggests that the father might have an important regulatory role in the natural history of his child’s oral HPV infection, which should be further explored.