bluuebunny/crossref_metadata_2025_split huggingface dataset:
Will career plateau lead to employee silence? A moderated mediation model
Authors: Jing Song , Zeng Yue , Xu Tian , Yin Qun , Ogbu Kenneth O. , Huang Ju 
Published: October 2022

Purpose
Career plateau and employee silence are negative employee management phenomena that should be overcome but are challenging. However, relatively speaking, when employees reach a particular career stage, it is inevitable that the hierarchical plateau in the career plateau will occur, while the phenomena of employee silence have the chance to improve. This paper aims to study the influence mechanism of the career plateau on employee silence in an uncertain environment and then provides theoretical support for enhancing the organizational phenomenon of employee silence.

Design/methodology/approach
After considering the effects of career plateau and social desirability of employee silence, this paper obtained 313 samples based on the pilot survey, which were collected anonymously online and offline. Based on passing the data quality test, this experiment uses hierarchical regression, Bootstrap method, interaction graph and slope test to test the mediating variable

Findings
The results show a significant positive correlation between career plateau and employees' silent behavior. Affective commitment plays a partial mediating role between career plateau and employees' silent behavior. Organizational justice not only negatively moderated the relationship between career plateau and affective commitment but also negatively moderated the indirect effect of career plateau on silent behavior through affective commitment.

Originality/value
First, based on the theory of uncertainty management and social exchange theory, this paper develops a behavioral response to the organizational environment based on the principle of fair exchange when employees perceive an uncertain environment. This study innovatively applied the two theories together in one study, establishing a link between the two theories. Second, this study explores the influence of career plateau on employee silence and empirically tests the silent behavior based on the previous division of three dimensions of career plateau. The third study explores affective commitment, the black box of the relationship between career plateau and employee silence. This research also enriches the related research on affective commitment.
Ulinastatin affects focal cerebral ischemia–reperfusion injury via SOCS1‐mediated JAK2/STAT3 signalling pathway
Authors: Chen Xiaoxi , Li Peng , Huang Renming , Zhang Juan , Ouyang Xingzhi , Tan Dianxiang 
Published: October 2022

AbstractCerebral ischemia results in loss of cerebral blood flow, which contributes to neuronal damage, neurocognitive impairment, as well as learning and memory difficulties. Although reperfusion is necessary to restore the blood supply to the brain, it also leads to several detrimental effects on the brain. The purpose of this study was to assess the effects of ulinastatin (UTI) on preventing focal cerebral ischemia/reperfusion‐induced injury (FCIRI). First, a rat model of FCIRI was established and treated with UTI. The effects of UTI on FCIRI in rats were evaluated using Morris water maze assay, triphenyl tetrazolium chloride staining, TUNEL, western blot assay, and enzyme‐linked immunosorbent assay analysis. UTI was found to improve the learning memory ability, reduce infarction area, inhibit apoptosis and decrease inflammation in FCIRI rats. Messenger RNA microarray analysis of hippocampal tissues revealed that suppressor of cytokine signalling‐1 (SOCS1) was the downstream target of UTI in FCIRI. SOCS1 depletion impaired the protective effect of UTI on FCIRI in rats. SOCS1 blocked the activation of the JAK2/STAT3 pathway. JAK2 inhibitor caused the JAK2/STAT3 pathway deficit, hence reversing the effect of sh‐SOCS1 on FCIRI in rats. Taken together, our results demonstrate that UTI alleviated FCIRI in rats, which was, to some extent, related to SOCS1‐mediated JAK2/STAT3 pathway.
Impact of salinity origin on microbial communities in saline springs within the Illinois Basin, USA
Authors: Zhao Linduo , Shao Hongbo , Zhang Li , Panno Samuel V. , Kelly Walton R. , Lin Tzu‐Yu , Liu Wen‐Tso , Flynn Theodore M. , Berger Peter 
Published: October 2022

AbstractSaline springs within the Illinois Basin result from the discharge of deep‐seated evaporated seawater (brine) and likely contain diverse and complex microbial communities that are poorly understood. In this study, seven saline/mineral springs with different geochemical characteristics and salinity origins were investigated using geochemical and molecular microbiological analyses to reveal the composition of microbial communities inhabiting springs and their key controlling factors. The 16S rRNA sequencing results demonstrated that each spring harbours a unique microbial community influenced by its geochemical properties and subsurface conditions. The microbial communities in springs that originated from Cambrian/Ordovician strata, which are deep confined units that have limited recharge from overlying formations, share a greater similarity in community composition and have a higher species richness and more overlapped taxa than those that originated from shallower Pennsylvanian strata, which are subject to extensive regional surface and groundwater recharge. The microbial distribution along the spring flow paths at the surface indicates that 59.8%–94.2% of total sequences in sedimentary samples originated from spring water, highlighting the role of springs in influencing microbiota in the immediate terrestrial environment. The results indicate that the springs introduce microbiota with a high biodiversity into surface terrestrial or aquatic ecosystems, potentially affecting microbial reservoirs in downstream ecosystems.
Illuminating the dark metabolome of Pseudo‐nitzschia–microbiome associations
Authors: Koester Irina , Quinlan Zachary A. , Nothias Louis‐Félix , White Margot E. , Rabines Ariel , Petras Daniel , Brunson John K. , Dührkop Kai , Ludwig Marcus , Böcker Sebastian , Azam Farooq , Allen Andrew E. , Dorrestein Pieter C. , Aluwihare Lihini I. 
Published: October 2022

AbstractThe exchange of metabolites mediates algal and bacterial interactions that maintain ecosystem function. Yet, while thousands of metabolites are produced, only a few molecules have been identified in these associations. Using the ubiquitous microalgae Pseudo‐nitzschia sp., as a model, we employed an untargeted metabolomics strategy to assign structural characteristics to the metabolites that distinguished specific diatom‐microbiome associations. We cultured five species of Pseudo‐nitzschia, including two species that produced the toxin domoic acid, and examined their microbiomes and metabolomes. A total of 4826 molecular features were detected by tandem mass spectrometry. Only 229 of these could be annotated using available mass spectral libraries, but by applying new in silico annotation tools, characterization was expanded to 2710 features. The metabolomes of the Pseudo‐nitzschia‐microbiome associations were distinct and distinguished by structurally diverse nitrogen compounds, ranging from simple amines and amides to cyclic compounds such as imidazoles, pyrrolidines and lactams. By illuminating the dark metabolomes, this study expands our capacity to discover new chemical targets that facilitate microbial partnerships and uncovers the chemical diversity that underpins algae‐bacteria interactions.
Agricultural diversification, productivity, and food security across time and space
Authors: Chavas Jean‐Paul , Rivieccio Giorgia , Di Falco Salvatore , De Luca Giovanni , Capitanio Fabian 
Published: October 2022

AbstractThis article presents an investigation of agricultural production risk over time and across space and its implications for food security. The econometric approach involves a Quantile Autoregressive (QAR) model and a copula to provide a flexible representation of the distribution of yield risk and its evolution over time and across space. The analysis relies on a two‐step estimation method to evaluate the multivariate yield distribution and its spatial and temporal evolution. Linkages between agricultural production risk and the economics of food security are explored, with implications for the welfare cost of food insecurity. The approach is illustrated in an econometric application to regional wheat and corn yields in Italy. The analysis provides new and useful information on the evolving linkages between agricultural production risk, productivity, and food security. Our integrated approach documents the role of regional diversification and of productivity growth along with their effects on food security.
The association of smoking, use of snuff, and preconception alcohol consumption with spontaneous abortion: A population‐based cohort study
Authors: Skogsdal Yvonne , Karlsson Jan , Tydén Tanja , Patil Snehal , Backman Helena 
Published: October 2022

AbstractIntroductionIt is unclear whether tobacco in early pregnancy and alcohol use preceding pregnancy are associated with spontaneous abortion. The purpose was to investigate if use of tobacco and/or alcohol is associated with spontaneous abortion among women attending antenatal care, and if age and body mass index (BMI) attenuate the risk.Material and MethodsA population‐based cohort study based on data from the Swedish Pregnancy Register. All pregnant women having had the first antenatal visit from January 2014 to July 2018 were included (n = 525 604). The register had information about smoking and use of snuff before and in early pregnancy, as well as data on alcohol habits before pregnancy, measured by the Alcohol Use Disorders Identification Test (AUDIT), a validated questionnaire. Logistic regression analysis was used to estimate the association between lifestyle factors and spontaneous abortion, and multiple imputation was used to impute missing data.ResultsIn total, 34 867 (6.6%) pregnancies ended in a spontaneous abortion after the first visit to maternal health care. At the first maternal healthcare visit, daily smoking was reported by 24 214 (5.1%), and 6403 (1.2%) used snuff. For 19 837 (4.2%) women, a high alcohol score was reported for the year preceding pregnancy. After adjusting for potential confounders and multiple imputation, use of tobacco was associated with spontaneous abortion; smoking 1–9 cigarettes/day (adjusted odds ratio [aOR] 1.11, 95% confidence interval [CI] 1.04–1.18), smoking 10 or more cigarettes/day (aOR 1.12, 95% CI 1.–1.26), and use of snuff (aOR 1.20, 95% CI 1.06–1.37). Higher AUDIT scores were not significantly associated with spontaneous abortion (AUDIT 6–9: aOR 1.03, 95% CI 0.97–1.10 and AUDIT 10 or more: aOR 1.07, 95% CI 0.94–1.22). Increasing maternal age showed the highest risk of spontaneous abortion from the age of 35, and BMI of 30 kg/m2 or more increased the risk. There were interactions between different lifestyle factors associated with spontaneous abortion that could either increase or decrease the risk of spontaneous abortion.ConclusionsSmoking and use of snuff were associated with an increased risk of spontaneous abortion. The AUDIT scores preceding pregnancy were not associated with an increased risk of spontaneous abortion, which contradicts the results from previous studies.
Population pharmacokinetics of sublingually administered tacrolimus in infants and young children with liver transplantation
Authors: Riva Natalia , Ibarra Manuel , Parra‐Guillen Zinnia P. , Galván Maria Eugenia , Pérez Erika , Trezeguet Renatti Guido , Cáceres Guido Paulo , Lopez Clarisa , Licciardone Nieves , Halac Esteban , Dip Marcelo , Cruz Alejandro , Imventarza Oscar , Buamscha Daniel , Troconiz Iñaki F. , Schaiquevich Paula 
Published: October 2022

AimsPharmacokinetics of tacrolimus after sublingual administration is not characterized in paediatric liver transplant patients. Therefore, we aimed to develop a population pharmacokinetic model of sublingually administered tacrolimus in patients who cannot swallow the capsules due to their age, sedation status and/or mechanical ventilation during the first weeks post‐transplantation.MethodsDemographic, clinical and pharmacological variables, including tacrolimus whole blood concentrations obtained from therapeutic drug monitoring and data from dense‐sampling pharmacokinetic profiles, were recorded in 26 paediatric patients with biliary atresia who underwent liver transplantation between 2016 and 2021. Population pharmacokinetic analysis was performed with NONMEM v7.4.ResultsDisposition of tacrolimus was best characterized by a 2‐compartment model with clearance achieving half of the maximum elimination capacity (CLMAX = 4.1 L/h) at 4.6 days post‐transplantation (T50). Compared to sedated patients, nonsedated status showed an increased first‐order absorption rate constant (1.1 vs. 0.1 h−1) and a 24% reduction in bioavailability (FNS) at 14 days post‐transplant. The model was able to explain the oral absorption pattern in nonsedated patients as the result of gut bioavailability (0.9) and hepatic extraction ratio, with the latter being responsible for first‐pass effects. Estimates of interindividual variability remained moderate (25.9% for the gut bioavailability) to high (79.8% for the apparent volume of distribution of the central compartment, and 101% for T50).ConclusionA population pharmacokinetic model of sublingually administered tacrolimus in paediatric patients was developed to characterize different absorption mechanisms. Once the model is externally validated, the effect of post‐transplant time on clearance and the sedation status may be considered in routine dosing management.
The psychology of income wealth threshold estimations: A registered report
Authors: Rinn Robin , Krishna Anand , Deutsch Roland 
Published: October 2022

AbstractHow do people estimate the income that is needed to be rich? Two correlative survey studies (Study 1 and 2, N = 568) and one registered experimental study (Study 3, N = 500) examined the cognitive mechanisms that are used to derive an answer to this question. We tested whether individuals use their personal income (PI) as a self‐generated anchor to derive an estimate of the income needed to be rich (= income wealth threshold estimation, IWTE). On a bivariate level, we found the expected positive relationship between one's PI and IWTE and, in line with previous findings, we found that people do not consider themselves rich. Furthermore, we predicted that individuals additionally use information about their social status within their social circles to make an IWTE. The findings from study 2 support this notion and show that only self‐reported high‐income individuals show different IWTEs depending on relative social status: Individuals in this group who self‐reported a high status produced higher IWTEs than individuals who self‐reported low status. The registered experimental study could not replicate this pattern robustly, although the results trended non‐significantly in the same direction. Together, the findings revealed that the income of individuals as well as the social environment are used as sources of information to make IWTE judgements, although they are likely not the only important predictors.
Developmental changes in students' use of dimensional comparisons to form ability self‐concepts in math and verbal domains
Authors: Wan Sirui , Lauermann Fani , Bailey Drew H. , Eccles Jacquelynne S. 
Published: October 2022

AbstractDimensional comparisons (i.e., comparing own performances across domains) may drive an increasing differentiation in students' math and verbal self‐concepts over time, but little longitudinal research has directly tested this assumption. Using cross‐sequential data spanning Grades 1–12 (N = 1069, ages 6–18, 92% White, 2% Black, 51% female, collected 1987–1996), this study charted age‐related changes in the role of dimensional comparisons in students' ability self‐concept formation. It used three types of self‐concept measures: peer comparisons, cross‐domain comparisons, and no comparisons. Results indicated that the increase in students' use of dimensional comparisons in self‐evaluations substantially contributed to the increasing differentiation in students' math and verbal self‐concepts over time. Findings highlight the importance of dimensional comparisons in the development of students' ability self‐concepts.
Clinical evaluations of alveolar ridge preservation in compromised extraction sockets with cortical‐lamina anchoring technique: Case series study
Authors: Guo Zehong , Yang Liqing , Kang Yujie , Wang Zhiping , Ren Fei , Sun Xuan , Yang Hong , Zhang Zhaoqiang 
Published: October 2022

AbstractObjectiveThe objective of this study is to retrospectively evaluate the clinical outcomes of alveolar ridge preservation (ARP) in the compromised extraction sockets using autogenous cortical‐lamina anchoring technique (CAT).Material and methodsTwenty patients were treated with ARP in the compromised extraction sockets by applying CAT. Then implant placement and crown delivery was performed. A planned follow‐up was performed by analyzing various outcome measures to evaluate the clinical outcomes, including primary outcome measures [radiographic assessment of residual alveolar ridge height (RARH) and residual alveolar ridge width (RARW)] and secondary outcome measures [clinical assessment of the healing of the soft and hard tissue, survival rates of implants, marginal bone loss (MBL) evaluation of implants, buccal bone thickness (BBT), and esthetic treatment outcomes].ResultsAmong the 20 patients, 17 were consecutively treated and 3 dropped out after implant crown delivery because of loss to follow‐up. After the ARP, the initial RARH (12.37 mm) significantly increased to 19.29 mm (P < .05). No significant difference was detected in the RARW before (7.92 ± 1.18 mm) and after (7.92 ± 1.18 mm) the ARP, but reduce to 6.99 ± 1.18 mm at the implant placement and 6.64 ± 0.77 mm at the 3‐year follow‐up (P < .05). The MBL at the implant crown delivery (0.13 ± 0.12 mm) significantly increased to 0.31 ± 0.14 mm at 1‐year follow‐up and 0.56 ± 0.23 mm at 3‐year follow‐up, respectively. The bone loss was limited (<1 mm) but statistically significant (P < .05). The BBT at the implant placement (2.53 ± 0.56 mm) significantly reduced to 2.23 ± 0.44 mm at implant crown delivery and 2.14 ± 0.40 mm at 3‐year follow‐up, respectively. The bone loss was also limited (<0.5 mm) but statistically significant (P < .05). Each implant site showed acceptable aesthetic outcome and the average score was 16.4. The incisions healed uneventful in all patients and the implant survival rate was 100% during the 3‐year follow‐up.ConclusionAutogenous CAT was successfully applied to preserve the height and width of alveolar ridge in the compromised extraction sockets.
Immunohistochemical comparison of lateral bone augmentation using a synthetic TiO2 block or a xenogeneic graft in chronic alveolar defects
Authors: Thieu Minh Khai Le , Stoetzel Sabine , Rahmati Maryam , El Khassawna Thaqif , Verket Anders , Sanz‐Esporrin Javier , Sanz Mariano , Ellingsen Jan Eirik , Haugen Håvard Jostein 
Published: October 2022

AbstractObjectivesTo evaluate osteogenic markers and alveolar ridge profile changes in guided bone regeneration (GBR) of chronic noncontained bone defects using a nonresorbable TiO2 block.Materials and MethodsThree buccal bone defects were created in each hemimandible of eight beagle dogs and allowed to heal for 8 weeks before GBR. Treatment was assigned by block randomization: TiO2 block: TiO2‐scaffold and a collagen membrane, DBBM particulates: Deproteinized bovine bone mineral (DBBM) and a collagen membrane, Empty control: Only collagen membrane. Bone regeneration was assessed on two different healing timepoints: early (4 weeks) and late healing (12 weeks) using several immunohistochemistry markers including alpha‐smooth muscle actin (α‐SMA), osteopontin, osteocalcin, tartrate‐resistant acid phosphatase, and collagen type I. Histomorphometry was performed on Movat Pentachrome‐stained and Von Kossa/Van Gieson‐stained sections. Stereolithographic (STL) models were used to compare alveolar profile changes.ResultsThe percentage of α‐SMA and osteopontin increased in TiO2 group after 12 weeks of healing at the bone‐scaffold interface, while collagen type I increased in the empty control group. In the defect area, α‐SMA decreased in the empty control group, while collagen type I increased in the DBBM group. All groups maintained alveolar profile from 4 to 12 weeks, but TiO2 group demonstrated the widest soft tissue contour profile.ConclusionsThe present findings suggested contact osteogenesis when GBR is performed with a TiO2 block or DBBM particulates. The increase in osteopontin indicated a potential for bone formation beyond 12 weeks. The alveolar profile data indicated a sustained lateral increase in lateral bone augmentation using a TiO2 block and a collagen membrane, as compared with DBBM and a collagen membrane or a collagen membrane alone.
Risk and survival in colorectal cancer with increasing body mass index: A nationwide population‐based cohort study
Authors: Saeed Usman , Myklebust Tor Å. , Robsahm Trude E. , Kielland Marlene F. , Møller Bjørn , Skålhegg Bjørn S. , Mala Tom , Yaqub Sheraz 
Published: October 2022

AbstractAimThe aim was to explore potential associations between the body mass index (BMI) and the risk of colorectal cancer (CRC), including subsites of the colon, and cancer‐specific death.MethodsA registry‐based cohort study was conducted with baseline data gathered from the Norwegian Tuberculosis Screening Programme, collected between 1963 and 1975, and linked to follow‐up data from the Cancer Registry of Norway and the Norwegian Cause of Death Registry. Cox regression models were used to explore associations between BMI and CRC risk and cancer‐specific death.ResultsOf 1 723 692 included individuals, 76 616 developed CRC during 55 370 707 person‐years of follow‐up. In men, a 5 kg/m2 increase in BMI was associated with an increased risk of colon cancer, including both right and left subsites, and rectal cancer. Allowing for nonlinearities, we found a U‐shaped association for the right colon and an inverse U‐shape for the left colon and rectum cancer. In women, a 5 kg/m2 increase in BMI in early adulthood was associated with increased risk of colon cancer, including both subsites. In women, an increased risk of CRC death with increasing BMI was found for colon cancer.ConclusionsMen of all ages have an increased risk of CRC with increasing BMI, with the highest risk for right‐sided colon cancer. An increased risk for colon cancer was also found in women with high BMI in early adulthood. Furthermore, women of all age groups appeared to have an increased risk of CRC death with higher BMI.