bluuebunny/crossref_metadata_2025_split huggingface dataset:
ECONOMIC ASSESSMENT OF INCREASING THERMAL PROTECTION OF MUNICIPAL BUILDINGS TO MODERN EUROPEAN REQUIREMENTS
Authors: Deshko Valerii , Buyak Nadiya , Bilous Inna , Naumchuk Olena 
Published: July 2022

According to the plan to reduce carbon dioxide emissions in Ukraine, there is a need to replace traditional energy sources and, accordingly, types of fuel. The paper highlights the main differences between the current regulatory documents in the field of energy efficiency of buildings, analyzes the dynamics of the energy demand of a public building during its thermal modernization to the normative indicators in force in Ukraine and Europe, and the regulation of the heating and ventilation schedule. The energy consumption assessment is based on the results of calculations in accordance with the current standard DSTU A.2.2 - 12:2015 and the building model in the DesignBuilder software environment. Using DesignBuilder helps evaluate new and existing building environmental performance, energy and comfort, HVAC, daylighting, cost, design optimization, CFD, BREEAM/LEED credits and reports that meet multiple national building codes and certification standards.
The influence of the economic indicators of Ukraine and Europe on the overall sensitivity of the project to increase the thermal protection of a public building is studied, taking into account the historical increase in energy prices in the countries under consideration. The work is the basis for further analysis and development of the concept of buildings with almost zero energy consumption in Ukraine.
Data-constrained analytical model for the propagation of a penny-shaped hydraulic fracture under true triaxial stresses
Authors: Feng Runhua , Sarout Joel , Dautriat Jeremie , Zhang Jiecheng , Roshan Hamid , Rezaee Reza , Sarmadivaleh Mohammad 
Published: July 2022

Abstract
Hydraulic fracturing is a coupled multi-physics and scale-dependent process requiring an extensive numerical-laboratory appraisal to assess feasibility in the field. Developing a robust model of hydraulic fracture propagation requires knowledge of the time evolution of the fracture’s geometrical attributes, e.g., width/aperture and length/radius. However, it is inherently challenging to directly measure even the simplest fracture attribute (i.e., radius) within a rock sample subjected to in-situ stresses in the laboratory, let alone in the field. In this study, an analytical model is developed to predict the time evolution of the radius for a penny-shaped hydraulic fracture. This model (Rd) predicts the fracture opening and internal pressure gradient using Poiseuille’s law and assuming a self-similar propagation. Scaling laws and dimensional analysis are used to define propagation regimes; and non-linear hydro-mechanical coupling is accounted for in the near-tip region. We also quantify the growth of the fracture radius using linear elastic fracture growth model (RE); and tip asymptotic solutions (RV and RT). A comparison of the three analytical models with published experimental data reveal that (i) the asymptotic solutions are limited to linearly elastic and homogeneous materials, i.e., PMMA; (ii) the performance of the linear elastic model (RE) poorly matches the experimental data, especially for unstable propagation situations; (iii) the new Rd model takes advantage of a robust reconstruction of the temporal radius growth of hydraulic fracture problems under realistic stress conditions, and including multiscale propagation regimes, cohesive effects, as well as stable and unstable propagation regimes of geomaterials.
The effect of volunteer-led activities on the quality of life of volunteers, residents, and employees of a long-term care institution: a cohort study
Authors: de Sandes-Guimarães Luisa Veras , Santos Patrícia Carla dos , Alves Carla Patricia Grossi Palácio , Cervato Carina Junqueira , Silva Ana Paula Alves , Leão Eliseth Ribeiro 
Published: July 2022

Abstract
Background: The COVID-19 pandemic primarily impacted long-term care facilities by restricting visiting and circulation, affecting the quality of life (QoL) of older adults living in these institutions. Volunteer activities, essential for older adults’ daily life, were also interrupted and potentially negatively impacted the QoL of older adults, volunteers themselves, and also employees in these institutions, although this three-fold effect was not yet investigated. In this context, this study aims to evaluate the impact of the return of volunteer-led activities in a long-term care institution on the QoL of older adult residents, employees, and volunteers. Methods: This study used a pre-test and post-test design within the same group. The first round of data collection was conducted before volunteer-led activities return and the second round after one month of return. The instrument used to assess QoL was the EUROHIS-QoL-8 scale. This study was conducted within a nursing home in São Paulo, Brazil, created in 1937 by members of the Israeli community living in Brazil. Volunteer-led activities were part of residents’ daily life before the COVID-19 pandemic, when these activities were interrupted for about 20 months. A total of 79 individuals participated in both rounds (pre and post), of which: 29 residents, 27 volunteers, and 23 employees of the long-term care institution. Results: Using a Wilcoxon signed-rank test, the analyses indicated improvements after the one month return in different QoL aspects for the three groups. Volunteers improved their personal relationships (Z -2.332, p< .05), residents their overall health (Z -2.409, p< .05) and employees in their overall QoL perception (Z -2.714, p< .05). Influencing factors for residents were the number of activities (3 or more), gender (male), and education (undergraduate/graduate). For employees, those who assumed additional activities due to the volunteer-led activities interruption had a significant impact on their overall QoL. Conclusions: Evidence from this study suggests that volunteers’ return positively impacted different QoL aspects for volunteers, residents, and employees.
25-Hydroxycholesterol Regulates Lysosome AMPK Activation and Metabolism Reprograming to Educate Immunosuppressive Macrophages
Authors: Wang Hongyan , Xiao Jun , Wang Shuang , Chen Longlong , Tang Huiru , Ding Xinyu , Ye Youqiong , Yang Dan , Zheng Yuxiao , Li Na , Dong Chen , Shen Huan , Hu Miao , Li Weiyun , Wei Bin 
Published: July 2022

Abstract
Different macrophage subsets exhibit anti-tumor or immunosuppression to regulate tumor progression. Cholesterol metabolism is vital to manipulate macrophage function. Here, we screened cholesterol enzymes and metabolites in three types of immunosuppressive macrophages, which all upregulated cholesterol-25-hydroxylase (Ch25h) expression to cause 25-hydroxycholesterol (25HC) accumulation. scRNA-seq data confirmed that MARCO+ and LYVE1+ macrophage subsets from various human cancers were Ch25hhigh subsets, correlated to lower survival rates. TEM including lactic Acid, Acidic pH and IL4/IL13 enhanced Ch25h expression, and targeting Ch25h abrogated macrophage immunosuppressive function to convert cold tumor into hot tumor, which also synergized with anti-PD1 therapy to improve antitumor efficacy. Critically, 25HC accumulation in lysosome acted as a novel AMPKα agonist, which enhances mitochondrial function and oxidative phosphorylation. We therefore propose Ch25h as an immunometabolic checkpoint and a drug target for tumor immunotherapy, which manipulates macrophage polarization and reshapes TME.
Computerized text and voice analysis - a quantitative single case study of seven chronically schizophrenic patients in art therapy
Authors: Sprotte Yvonne 
Published: July 2022

Abstract
This explorative study of chronic schizophrenic patients aims to clarify whether group art therapy followed by a therapist-guided picture review could influence the patients' communication behavior. Characteristics of voice and speech were obtained via objective technological instruments and selected as indicators of communication behavior. Seven patients were recruited to participate in weekly group art therapy over a period of six months. Three days after each group meeting, they talked about their last picture during a standardized interview that was digitally recorded. The audio documents were evaluated using validated computer-assisted procedures, the transcribed texts using the German version of LIWC2015, and the voices using the audio analysis software VocEmoApI. The dual methodological approach was intended to form an internal control of the study results. An exploratory factor analysis of the complete sets of output parameters was carried out in the expectation of obtaining disease typical characteristics in speech and voice that map barriers to communication. The parameters of both methods were thus processed into five factors each, i.e., into a quantitative digitized classification of the texts and voices. The scores of the factors were subjected to a linear regression analysis to capture possible process-related changes. Most patients continued to participate in the study. This resulted in high quality data sets for statistical analysis. In answer to the study question, two results were summarized: A text analysis factor called presence proved a potential surrogate parameter for positive language development. Quantitative changes in vocal emotional factors were detected, demonstrating differentiated activation patterns of emotions. These results can presumably be interpreted as an expression of a cathartic healing process. The methods presented in this study make a potentially significant contribution to quantitative research into the effectiveness and mode of action of art therapy.Trial Registration: ISRCTN12365070Acronym: Linguistic and Voice inquiry of patients talking about their own Pictures (LiVoPict)
Addressing the effect of meteorological factors and agricultural subsidy on agricultural productivity in India: A roadmap towards environmental sustainability
Authors: Baig Imran Ali , Irfan Muhammad , Salam Md. Abdus , Işik Cem 
Published: July 2022

Abstract
In the last two decades, the extensive literature that has measured agricultural productivity and growth rate remains controversial and provides few strategies about its main determinants. The present study aims to find out the key determinants of food grain yield (FGY) and examine the role of climate change and agricultural subsidy (SUB) in the context of India using annually data spanning from 1991 to 2018. The current study applied the ARDL modelling to investigate the impacts of climatic factors (average rainfall (RF), mean temperature (AT), and carbon emission (CO2) and agricultural subsidy (SUB) on food grain yield (FGY) in the short-and long-term in India. The estimated outcomes indicate that climatic factors such as RF have a positive impact while AT and CO2 have a negative effect on FGY. Similarly, non-climate variables such as gross capital formation (GCF) and fertilizer usage (FERT) positively contributed to FGY, while the area under crop (LUC), SUB, and employment (AL) negatively affected FGY in India. The results from Granger causality divulge that climatic and non-climatic elements are the main determinants of food grain yield, which have been playing play a significant role in enhancing food grain production and ensuring food security in India. Based on empirical outcomes and findings, some key policy implications emerged. Precisely, government and policy developers should focus on technological innovation and precision agriculture to increase agriculture production and productivity. Government should create funds to curb the climate change problem and promote eco-friendly renewable energy.
Feasibility and Acceptability of a New Web-based Cognitive Training Platform for Older Adults: the Breakfast Task
Authors: Simon Sharon Sanz , Ben-Eliezer Daniel , Pondikos Maria , Stern Yaakov , Gopher Daniel 
Published: July 2022

Abstract
Background: Developing efficient cognitive training for the older population is a major public health goal due to its potential cognitive benefits. A promising training target is executive control, critical for multitasking in everyday life. The aim of this pilot study was to establish the feasibility and acceptability of the Breakfast Task training in older adults, a new web-based cognitive training platform that simulates real-life multitasking demands. Methods: A community-based sample of 24 cognitively healthy participants aged between 60 and 75 ( M = 69.12, SD = 3.83) underwent 5-session cognitive training protocol, delivered online. Each session lasted 45 minutes and occurred twice a week at participant’s homes. Performance was recorded, and participants completed questionnaires at baseline and after the intervention. Results: Feasibility metrics showed overall high recruitment (82.7%), adherence and retention rates (100%). Acceptability was considered good based on participant`s quantitative and qualitative responses. On average, participants rated the game as interesting, enjoyable and did not report difficulties in accessing the game online without supervision or in understanding the instructions. Participants showed a learning curve across sessions, suggesting improvement in the game outcomes and potential benefits from the emphasis change training approach. The study identified relevant areas that need improvements and adjustments, such as technical issues, session’s structure and dose. Conclusions: The findings provide preliminary support for the feasibility and acceptability of the Breakfast Task training platform in cognitively healthy older adults, with promising potential cognitive benefits. Results suggest the value of further research investigating the Breakfast Task training features and dose-response relationship, as well as its potential efficacy in older adults via larger randomized controlled trials. Trial Registration: ClinicalTrials.gov : NCT04195230 (Registered 11 December 2019). https://clinicaltrials.gov/ct2/show/NCT04195230
Improving the Photovoltaic Characteristics for n-CdS/p-Cu 2 ZnSnS 4 Solar Cells by annealing: Structural, Morphological and Optical Properties
Authors: Aboraia A. M. , Saad Mohamed , ALMohiy Hussain , Shaaban E. R. 
Published: July 2022

Abstract
Owing to its direct bandgap in the range to be used as an absorbent material and due to its high absorption rate, kesterite Cu2ZnSnS4 (CZTS) is a p-type prospective absorber material for solar cell applications. Kesterite Cu2ZnSnS4 (CZTS) thin films were prepared using the thermal evaporation technique. Thermogravimetric analysis (TGA) was first performed for the (CZTS) nanoparticles. The (CZTS) thin films were annealed at different annealing temperatures chosen according to TGA analysis in the range of (400oC, 450oC, 475oC, and 500oC). The influence of annealing temperatures on the structural, morphology and optical properties of the CZTS was studied. The XRD patterns and Raman spectra have exposed the creation of CZTS thin with a high-quality crystal structure. The refractive index n, and extinction coefficient, k therefore energy gap are assessed from mathematical model of spectroscopic ellipsometry. The n and k values of the CZTS /glass films established from SE model rise with increasing the annealing temperature owing to the growth of the crystallites size. It is observed that the direct optical transition with energy gap is compressed from 1.73 eV at RT to 1.51 eV at maximum crystallization 500 oC. The photovoltaic traits of the fabricated n-CdS/p-CZTS junction were investigated for a solar cell. The heterojunction of Ni/n-CdSe/p-CdTe/Pt has been well constructed. The dark and illumination (current-voltage) traits of assembled heterojunctions had been recommended at distinctive different annealing of CZTS layer and the voltages ranging from − 2 to 2 volts.
Evaluation of strategies for the occupational health risk assessment of chemical toxicants in the workplace based on a quantitative analysis model
Authors: Cao Yiyao , Zou Hua , Zhang Meibian , Xu Lingtong , Ren Hong , Wang Peng , Yuan Weiming , Shao Xincun , Zhou Zhen , Xu Qiuliang 
Published: July 2022

Abstract
Objectives: The commonly used methods for the occupational health risk assessment (OHRA) of chemical toxicants cannot fully meet the needs of practical work. This study evaluated OHRA strategies for chemical toxicants in the workplace by establishing a quantitative analysis model. Methods: Five typical industries in China that implement OHRA using the six common models (the Environmental Protection Agency, Australian, Romanian, Singaporean, International Council on Mining and Metals, and the Control of Substances Hazardous to Health models) were selected as the research objects. We established a quantitative analysis model to compare the six models and applied it to compare the results obtained using each model and preliminarily analyze the advantages, limitations, and application scope of each method. Results: The risk ratio (RR) values of the six methods decreased in the following order: RR EPA > RR COSHH > RR ICMM > RR Australia > RR Singaporean > RR Romanian (P < 0.05). Among the six models, the Singaporean model had the strongest RR correlation with the other models (P < 0.01). The sequence of RRs obtained from the Singaporean, ICMM, Australian, and Romanian models in the five industries was consistent with the sequence of the three inherent risk levels in those industries. Only the Romanian model could distinguish between the RRs of all five industries. The EPA and Singaporean models could effectively distinguish the differences in inherent risk for four hazard factors (manganese and inorganic compounds, benzene, xylene, and ethyl acetate), with the assessment accuracy being higher for the EPA model.Conclusions: The EPA model had the highest accuracy in assessing chemical toxicants followed by the Singaporean model. The EPA and Romanian models were strongest in differentiating the differences in toxicity risk.
Establishment of a scoring model for the differential diagnosis of white coat hypertension and sustained hypertension
Authors: Cai Peng , Lin Qingshu , Zhang Jing , Lv Dan , Wang Yan , Wang Xukai 
Published: July 2022

Abstract
This study aimed to establish a scoring model for the differential diagnosis of white coat hypertension (WCH) and sustained hypertension (SHT). 553 adults with elevated office blood pressure, normal renal function and no antihypertensive drugs were included in this study. 17 parameters, such as gender and age, were obtained by questionnaire investigation and biochemical detection. WCH and SHT were distinguished by 24-hour ambulatory blood pressure monitoring. Participants were randomly divided into a training set (445 cases) and a validation set (108 cases). In the training set, the above parameters were screened by LASSO regression and univariate logistic regression analysis, then, the scoring model was constructed through multivariate logistic regression analysis. ROC curve and calibration curve were used to discuss the discrimination and calibration of this scoring model respectively. 6 parameters were finally selected, namely isolated systolic hypertension, systolic blood pressure, diastolic blood pressure, triglyceride, serum creatinine, and cardiovascular and cerebrovascular diseases. Multivariate logistic regression was used to establish the scoring model. The R2 and AUC of the scoring model in the training set were 0.163 and 0.705, respectively. In the validation set, the R2 of the scoring model was 0.206, and AUC was 0.718. The calibration test results showed that the scoring model had good stability in both training set and validation set (MSE = 0. 001, MAE = 0. 014; MSE = 0. 001, MAE = 0. 025, respectively). A stable scoring model for distinguishing WCH can be established, which can assist clinician to identify WCH at the first diagnosis.
Nano-composite based Smart Electrochromic Device with escalated transmittance
Authors: Talukdar Silpee , Dhar Rudra Sankar 
Published: July 2022

Abstract
Nanocomposites based Electrochromic Membrane Device (EMD) is fabricated by using DC sputtering with differently doped nanomembranes WO3 doped Ag NW and Li+, PEO, and H+Nb2O5 which undergoes optical and electrochemical characteristics so as to be capabale for smart applications. Highest bleaching transmittance of this device is evaluated to be 96.1% at 549nm and 93.1% at 825nm in the visible and IR spectra. Average colouration transmittance is observed to be 11.1% over visible range and 2.6% over IR range. A comparison with existing devices are also studied and analysed to understand the benefit of the EMD device. Dimming fastness of EMD on 500, 550 and 600nm upon a certain wavelength counted as 105, 111 and 150sec, respectively. Both transmittance modulation and optical density are also computed as 85% and 0.94. Cyclic voltammetry of each film and the whole nanostructured device arrangement is carried out for 50mV/s over +1.5V to 1.5V in the standard environment, which overlayed the understanding of the quantum tunnelling and carrier confinement effects in the device that leads to enhanced device performance. Whole experimentation of EMD stands out as an imperative accomplishment for standard requirements to be fit for future smart applications.
Free Flap Friday: Interdisciplinary clinic implementation and outcomes for patients undergoing head and neck cancer surgery
Authors: Scheel Teddy , Sedki Sarah , O'Riordan David , Yang Sky , Conto Mandy , Sheedy Trina , Macaire Greta , Rabow Michael , Ha Patrick 
Published: July 2022

Abstract
Purpose:Patients with complex head and neck cancer benefit from preoperative education and multidisciplinary support. However, such care may not adequately address the need for advance care planning (ACP) in the preoperative setting. We evaluated the feasibility and impact of “Free Flap Fridays” (FFF), a comprehensive preoperative education program that offers recommendations to patients undergoing head and neck surgery with free flap reconstruction. The program is led by an interdisciplinary team comprised of social work, surgical nursing, speech and language pathology, nutrition, and specialty palliative care. Methods: This study was a quantitative, retrospective chart review analysis at an academic cancer center. We compared demographics pre- and post-surgical engagement with the interdisciplinary team, and ACP outcomes, among 48 patients who participated in FFF and 44 patients who received usual care prior to the launch of the FFF clinic. Results:Preoperative involvement of each of the five disciplines included in the interdisciplinary team increased among the intervention group. Engagement with FFF increased rates of advance care planning discussions (66.7% vs. 4.5%, p<0.0001). Documentation of a durable power of attorney also increased between the groups (72.9% vs. 31.8%, p<0.0001), although there was no difference in completed advance care documents, including advance directives or Physician Orders for Life Sustaining Treatment (POLST) documents. Conclusions:Implementation of an interdisciplinary, preoperative clinic for patients undergoing free flap reconstruction for head and neck cancer is feasible and leads to increased patient engagement and preoperative ACP discussions.