bluuebunny/crossref_metadata_2025_split huggingface dataset:
NNMT‐DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition
Authors: Wu Changqing , Liu Yu'e , Liu Wenju , Zou Tianhui , Lu Shaojuan , Zhu Chengjie , He Le , Chen Jie , Fang Lan , Zou Lin , Wang Ping , Fan Lihong , Wang Hongxiang , You Han , Chen Juxiang , Fang Jing‐Yuan , Jiang Cizhong , Shi Yufeng 
Published: November 2022

AbstractLacking a clear understanding of the molecular mechanism determining cancer cell sensitivity to oxidative phosphorylation (OXPHOS) inhibition limits the development of OXPHOS‐targeting cancer treatment. Here, cancer cell lines sensitive or resistant to OXPHOS inhibition are identified by screening. OXPHOS inhibition‐sensitive cancer cells possess increased OXPHOS activity and silenced nicotinamide N‐methyltransferase (NNMT) expression. NNMT expression negatively correlates with OXPHOS inhibition sensitivity and functionally downregulates the intracellular levels of S‐adenosyl methionine (SAM). Expression of DNA methyltransferase 1 (DNMT1), a SAM consumer, positively correlates with OXPHOS inhibition sensitivity. NNMT overexpression and DNMT1 inhibition render OXPHOS inhibition‐sensitive cancer cells resistant. Importantly, treatments of OXPHOS inhibitors (Gboxin and Berberine) hamper the growth of mouse tumor xenografts by OXPHOS inhibition sensitive but not resistant cancer cells. What's more, the retrospective study of 62 tumor samples from a clinical trial demonstrates that administration of Berberine reduces the tumor recurrence rate of NNMTlow/DNMT1high but not NNMThigh/DNMT1low colorectal adenomas (CRAs). These results thus reveal a critical role of the NNMT‐DNMT1 axis in determining cancer cell reliance on mitochondrial OXPHOS and suggest that NNMT and DNMT1 are faithful biomarkers for OXPHOS‐targeting cancer therapies.
Genetic polymorphism of fatty acid binding protein‐2 in hyperlipidemic Asian Indians in North India
Authors: Meena Kiran , Misra Anoop , Vikram Naval , Ali Shakir , Upadhyay Ashish Datt , Luthra Kalpana 
Published: November 2022

AbstractBackgroundFatty acid binding protein‐2 (FABP‐2) is involved in the metabolism of lipids in the intestine. FABP‐2 Ala54Thr polymorphism involves a transition of G to A at codon 54 of FABP‐2, resulting in an amino acid substitution Ala54 to Thr54 and is associated with elevated fasting triglycerides in some hyperlipidemic populations.In current genome builds and gene databases the variant of the Ala54Thr FABP‐2 (rs 1 799 883) is annotated as c.163A>G (p. Thr55Ala).Aim and ObjectiveThe status of this polymorphism in hyperlipidemic Asian Indians from North India has not been investigated. This study was aimed to evaluate the distribution of the polymorphic variants of the Ala54Thr FABP‐2 and their association with lipids in hyperlipidemic subjects.MethodsAla54Thr FABP‐2 polymorphism in both hyperlipidemic (n = 210) and normolipidemic (n = 342) subjects was assessed by PCR‐RFLP.ResultsAla54Thr genotypes and alleles distribution did not differ between the hyperlipidemic and normolipidemic groups.The heterozygous genotype FABP‐2 Ala/Thr was significantly associated with higher levels of triglycerides and very low‐density lipoproteins as compared to the homozygous variant (Thr/Thr) genotype and the wild type homozygous (Ala/Ala) genotype.ConclusionsThe heterozygous genotype FABP‐2 Ala54Thr is a risk factor for the development of hypertriglyceridemia and increased levels of VLDL‐c in Asian Indians from North India.
Growth charts for Marfan syndrome in the Netherlands and analysis of genotype–phenotype relationships
Authors: Lauffer Peter , Pals Gerard , Zwinderman Aeilko H. , Postema Floor A. M. , Baars Marieke J. H. , Dulfer Eelco , Hilhorst‐Hofstee Yvonne , Houweling Arjan C. , Kempers Marlies , Krapels Ingrid P. C. , van de Laar Ingrid M. B. H. , Loeys Bart , Spaans Alexander M. J. , Warnink‐Kavelaars Jessica , de Waard Vivian , Wit Jan M. , Menke Leonie A. 
Published: November 2022

AbstractTo optimize care for children with Marfan syndrome (MFS) in the Netherlands, Dutch MFS growth charts were constructed. Additionally, we aimed to investigate the effect of FBN1 variant type (haploinsufficiency [HI]/dominant negative [DN]) on growth, and compare MFS‐related height increase across populations. Height and weight data of individuals with MFS aged 0–21 years were retrospectively collected. Generalized Additive Models for Location, Scale and Shape (GAMLSS) was used for growth chart modeling. To investigate genotype–phenotype relationships, FBN1 variant type was included as an independent variable in height‐for‐age and BMI‐for‐age models. MFS‐related height increase was compared with that of previous MFS growth studies from the United States, Korea, and France. Height and weight data of 389 individuals with MFS were included (210 males). Height‐for‐age, BMI‐for‐age, and weight‐for‐height charts reflected the tall and slender MFS habitus throughout childhood. Mean increase in height of individuals with MFS compared with the general Dutch population was significantly lower than in the other three MFS populations compared to their reference populations. FBN1‐HI variants were associated with taller height in both sexes, and decreased BMI in females (p‐values <0.05). This Dutch MFS growth study broadens the notion that genetic background and MFS variant type (HI/DN) influence tall and slender stature in MFS.
Azaarenes: 13 Ringe in einer Reihe durch Cyclopentanellierung
Authors: Maier Steffen , Hippchen Nikolai , Jester Fabian , Dodds Marcus , Weber Michel , Skarjan Leon , Rominger Frank , Freudenberg Jan , Bunz Uwe H. F. 
Published: November 2022

AbstractEine Cyclopentanellierungsstrategie wird für den Zugang zu langen, stabilen Azaarenen vorgestellt. Buchwald–Hartwig‐Kupplung von literaturbekannten di‐ und tetrabromierten cyclopentaneliertenN,N′‐Dihydrotetraazapentacenen lieferte stabile Azaarene mit bis zu 13 linear anellierten Benzolringen und einer Länge von 3.1 nm. Ihre optoelektronischen und halbleitenden Eigenschaften sowie ihre Aromatizität wurden untersucht.
Site‐Selective Electrochemical C−H Carboxylation of Arenes with CO2
Authors: Zhao Zhiwei , Liu Yin , Wang Siyi , Tang Shunyao , Ma Dengke , Zhu Zile , Guo Chengcheng , Qiu Youai 
Published: November 2022

AbstractHerein, a direct, metal‐free, and site‐selective electrochemical C−H carboxylation of arenes by reductive activation using CO2as the economic and abundant carboxylic source was reported. The electrocarboxylation was carried out in an operationally simple manner with high chemo‐ and regioselectivity, setting the stage for the challenging site‐selective C−H carboxylation of unactivated (hetero)arenes. The robust nature of the electrochemical strategy was reflected by a broad scope of substrates with excellent atom economy and unique selectivity. Notably, the direct and selective C−H carboxylation of various challenging arenes worked well in this approach, including electron‐deficient naphthalenes, pyridines, simple phenyl derivatives, and substituted quinolines. The method benefits from being externally catalyst‐free, metal‐free and base‐free, which makes it extremely attractive for potential applications.
Unlocking Charge Transfer Limitations for Extreme Fast Charging of Li‐Ion Batteries
Authors: Yao Yu‐Xing , Chen Xiang , Yao Nan , Gao Jin‐Hui , Xu Gang , Ding Jun‐Fan , Song Chun‐Liang , Cai Wen‐Long , Yan Chong , Zhang Qiang 
Published: November 2022

AbstractExtreme fast charging (XFC) of high‐energy Li‐ion batteries is a key enabler of electrified transportation. While previous studies mainly focused on improving Li ion mass transport in electrodes and electrolytes, the limitations of charge transfer across electrode–electrolyte interfaces remain underexplored. Herein we unravel how charge transfer kinetics dictates the fast rechargeability of Li‐ion cells. Li ion transfer across the cathode–electrolyte interface is found to be rate‐limiting during XFC, but the charge transfer energy barrier at both the cathode and anode have to be reduced simultaneously to prevent Li plating, which is achieved through electrolyte engineering. By unlocking charge transfer limitations, 184 Wh kg−1 pouch cells demonstrate stable XFC (10‐min charge to 80 %) which is otherwise unachievable, and the lifetime of 245 Wh kg−1 21700 cells is quintupled during fast charging (25‐min charge to 80 %).
Molecular/Ionic Designs in the Electrolyte and Interphases for Lithium Metal Anode
Authors: Yin Xiangkai , Li Xinyang , Cui Xiaofeng , Liu Limin , Weng Xianjun , Ding Shujiang , Yu Wei 
Published: November 2022

AbstractThe undesirable interactions between the charge carriers (Li+) and various objects in the special microenvironment of batteries would cause uneven lithium (Li) metal deposition behavior, which severely impedes the application of Li metal batteries (LMBs). In recent years, many works focus on optimizing these interactions by functional molecules/ions modification. Nevertheless, related reviews are still absent. Here, this review introduces the regulation methods of Li metal deposition from molecular/ionic designs, which is a new perspective including Li+ flux homogenization, the de‐solvation process regulation, optimizing the solid electrolyte interphase (SEI) in conventional solvation structure and anion‐rich solvation structure. Also, the general design principles are studied in each mechanism and some suggestions are proposed in the prospective future directions, aiming to guide the development of molecular/ionic designs and the actual application of LMBs with high energy densities.
In the Shadow of the 1919 Total Solar Eclipse: The Two British Expeditions and the Politics of Invisibility**
Authors: Simões Ana 
Published: November 2022

AbstractThis paper addresses the legendary total solar eclipse of 29 May 1919. Two British teams confirmed the light bending prediction by Albert Einstein: Charles R. Davidson and Andrew C. C. Crommelin in Sobral, Brazil and Arthur S. Eddington and Edwin T. Cottingham on the African island of Príncipe, then part of the Portuguese empire.By jointly analyzing the two astronomical expeditions supported by written and visual sources, I show how, despite extensive scholarship on this famous historical episode and the historiographical emphasis on the plural dimensions of knowledge construction, many human and non‐human actors have been kept in the shadow of the eclipse. I do so by focusing on what I call knowledge from the periphery together with knowledge from below, grounded literally on how localities (sites) affect choices and events, and growing outward to encompass a wide range of participants. I show how the geopolitical status of the two nations where the observational sites were located, and specifically Portugal's condition of colonial power, affected main decisions and events, while highlighting the active role of participants, ranging from experts from the peripheries and those involved in the travels to local elites and anonymous peoples, some of whom contributed to the observation of totality.
Comparison of mechanistic and hybrid modeling approaches for characterization of a CHO cultivation process: Requirements, pitfalls and solution paths
Authors: Bayer Benjamin , Duerkop Mark , Pörtner Ralf , Möller Johannes 
Published: November 2022

AbstractDespite the advantages of mathematical bioprocess modeling, successful model implementation already starts with experimental planning and accordingly can fail at this early stage. For this study, two different modeling approaches (mechanistic and hybrid) based on a four‐dimensional antibody‐producing CHO fed‐batch process are compared. Overall, 33 experiments are performed in the fractional factorial four‐dimensional design space and separated into four different complex data partitions subsequently used for model comparison and evaluation. The mechanistic model demonstrates the advantage of prior knowledge (i.e., known equations) to get informative value relatively independently of the utilized data partition. The hybrid approach displayes a higher data dependency but simultaneously yielded a higher accuracy on all data partitions. Furthermore, our results demonstrate that independent of the chosen modeling framework, a smart selection of only four initial experiments can already yield a very good representation of a full design space independent of the chosen modeling structure. Academic and industry researchers are recommended to pay more attention to experimental planning to maximize the process understanding obtained from mathematical modeling.
Climate change performance and financial distress
Authors: Alshahrani Faisal , Eulaiwi Baban , Duong Lien , Taylor Grantley 
Published: November 2022

AbstractGiven the crucial role that environmental accounting plays in sustainable development, this study investigates the relationship between climate change disclosure performance (CCDP) and financial distress as well as the moderating impact of litigation, the existence of a risk committee, the employment of Big4 auditing firms and the level of audit fees. Utilising a sample of the top 300 Australian Securities Exchange (ASX)‐listed non‐financial firms over the period 2008–2019 and ordinary least squares (OLS) regression analysis with fixed effects, it is found that higher levels of CCDP are related to lower levels of financial distress. Additionally, the significant association between CCDP and financial distress is manifested in firms with low litigation risk, firms with a risk committee, firms that employ Big4 auditing firms and firms that incur a higher level of audit fees. Additional tests that mitigate self‐selection and endogeneity, such as propensity score matching (PSM) and the system generalised method of moments (GMM), show that our findings are robust. Finally, our findings shed light on managers' strategic behaviour in relation to the consideration of, and transparency around, climate change risks.
‘I wanna be sustainable, but I don't wanna show it!’: The effect of sustainability cues on young adult consumers' preferences
Authors: Fani Virginia , Mazzoli Valentina , Acuti Diletta 
Published: November 2022

AbstractGiven the urgent need to address plastic pollution, fashion companies are implementing diverse strategies to reduce plastic in their production processes. To communicate their commitment to plastic waste reduction, companies have started including symbols on their products (i.e., sustainability cues). However, the effect of these symbols on consumer behaviour remains unclear. Thus, through a mixed method involving three focus groups and two online experiments, we investigate the effect of sustainability cues on consumers' preferences. Our findings show that including sustainability cues on a product is not always an effective business strategy. Hence, we expand the ongoing debate on the effects of environmental strategies, offering new insights into consumers' perceptions of sustainability cues and demonstrating the importance of perceived proximity and environmental concern in enhancing or reducing buying intentions towards sustainable products. For fashion companies, we reveal if and how sustainability cues can represent a competitive leverage prompting environmentally friendly purchases.
A Newabeo‐Icetexane‐Type Diterpenoid from the Stem Barks ofTaxus wallichiana
Authors: Dang Phu Hoang , Nguyen Hai Xuan , Le Tho Huu , Van Do Truong Nhat , Nguyen Mai Thanh Thi , Nguyen Nhan Trung 
Published: November 2022

AbstractFrom a CH2Cl2‐soluble fraction of the stem barks ofTaxus wallichiana, one newabeo‐icetexane‐type diterpenoid, taxamairin I (1), was isolated. Its absolute configuration was elucidated based on spectroscopic interpretation and time‐dependent density functional theory (TD‐DFT) calculation of optical rotation. In addition, the plausible biosynthesis pathway for the formation of the newabeo‐icetexane‐type diterpenoid was proposed. Taxamairin I (1), at a concentration of 100 μM, did not show cytotoxicity against Hep3B human liver cancer cell lines.
Comparative Study on Volatile Oils among Bupleuri radix Species and Habitats: Yields, Chemical Characterization and Antipyretic Activities
Authors: Chen Ruoqiao , Wang Xiaoshuang , Xu Hongting , Zhao Ruizhi , Hu Qiaohong 
Published: November 2022

AbstractVolatile oils from several Bupleuri radix (BR) are reported as potential sources of drugs. To provide evidence for the application of BR, the volatile oils from 19 batches of different species and habitats of BR including Bupleurum chinese DC. (BCD), Bupleurum scorzonerifolium Willd. (BSW), Bupleurum bicaule Helm (BBH), Bupleurum marginatum var. stenophyllum (Wolff) Shan et Y.Li (BMS), Bupleurum marginatum Wall.ex DC. (BMW) and Bupleurum falcatum L. (BFL) were investigated. The composition of BR volatile oils was determined by GC/MS. Samples were clustered by hierarchical cluster analysis (HCA). Fever was induced by Lipopolysaccharide (LPS), and antipyretic activities of BR volatile oils were evaluated with Chaihu injection (CI) as the positive control. The yields of volatile oils were among 360–5320 ppm. A total of 229 components were identified by GC/MS. Samples could be divided into 4 clusters by HCA. 4 representative samples, one for each cluster, were selected to further compare their antipyretic activities. For the highest content of volatile oil (5320 ppm) and the best activity, BSW has great potential for utilization.
Binding Properties of Photosynthetic Herbicides: Photosynthetic Activity and Molecular Docking Approach towards 1,4‐Dihydropyridines Derivatives
Authors: Soares Luís T. X. M. G. , Basso Marcelo A. F. , dos Santos Clarice M. R. , Ali Akbar , Vasconcelos Leonardo G. , Dall'Oglio Evandro L. , Sampaio Olívia M. , Vieira Lucas C. C. 
Published: November 2022

AbstractIn the current work, we describe the synthesis of 1,4‐dihydropyridine (1,4‐DHP) derivatives via Hantzsch multicomponent reaction and their evaluation as photosystem II (PSII) inhibitors through chlorophyll a fluorescence bioassay. Among all the compounds tested, 1,1′‐(2,4,6‐trimethyl‐1,4‐dihydropyridine‐3,5‐diyl)bis(ethan‐1‐one) (4b) showed best results, reducing the parameters performance index on absorption basis (PIabs) and electron transport per reaction center by 61 % and 49 %, respectively, as compared to the control. These results indicate the inhibitory activity of PSII over the electron transport chain. Additionally, a molecular docking approach using the protein D1 (PDB code 4V82) was performed in order to assess the structure‐activity relationship among the 1,4‐DHP derivatives over the PSII, which revealed that both, size of the group at position 4 and the carbonyl groups at the dihydropyridine ring are important for the ligand's interaction, particularly for the hydrogen‐bonding interaction with the residues His215, Ser264, and Phe265. Thus, the optimization of these molecular features is the aim of our research group to extend the knowledge of PSII electron chain inhibitors and the establishment of new potent bioactive molecular scaffolds.
Beneficial Effect of β‐Cyclodextrin Assisted Synthesis of CuO/Hydroxyapatite Catalyst in Toluene Oxidation
Authors: Ibrahim Maya , Labaki Madona , Ponchel Anne , Giraudon Jean‐Marc , Gardoll Olivier , Lamonier Jean‐François 
Published: November 2022

AbstractTwo hydroxyapatite supported CuO (10 wt% Cu) catalysts were prepared using the wet impregnation method via the conventional process and with the addition of native β‐cyclodextrin using Cu(NO3)2.3H2O as copper precursor and adopting a ratio of β‐cyclodextrin to copper of 0.1. After the impregnation step, the materials were dried at 80 °C and calcined in flowing dry air at 400 °C. The copper supported materials were characterized in the dried state and after calcination by means of conventional methods including X‐ray diffraction, TG‐MS, H2‐TPR‐MS, Raman spectroscopy, UV‐vis‐DR, ToF‐SIMS and XPS. It was found that β‐cyclodextrin hasd a profound impact on the final properties of the catalysts, both in terms of reducibility and dispersion of active species. It is suggested that at the early stages of the calcination, some hydroxyl groups of the β‐CD units in close contact with Ca2+ of hydroxyapatite could play the role of spacers between the copper‐based entities thus minimizing the aggregation process of the CuO nanoparticles. Finally, these copper oxide catalysts prepared from β‐cyclodextrin were able to oxidize toluene more efficiently than the conventional catalyst. The copper oxide particles generated by the thermal decomposition of Cu2(OH)3(NO3) were smaller than those formed with copper nitrate alone and exhibited a higher reducibility, two key determinants for VOC total oxidation on transition metal oxides.
Stereodirecting Effects of 4‐O‐ortho‐cyanobenzyl Ether on Chemical Glycosylation with Glucopyranosyl Donor
Authors: Zhang Han , Guo Aoxin , Meng Youhui , Wang Yue , Gao Jian , Liu Xue‐Wei 
Published: November 2022

Comprehensive SummaryHere we report a systematic investigation on the stereodirecting effects of a 4‐O‐ortho‐cyanobenzyl ether (oBCN) group with a glucopyranosyl donor. Experimental studies revealed that the glycosylation reactions using this donor generally show dual‐stereoselectivities depending on the acceptor nucleophilicity, that is, glycosylation of weak nucleophile acceptors generally affords α‐glycosides specifically while glycosylation of strong nucleophile acceptors affords β‐glycosides preferentially. DFT computations suggested that strong nucleophiles preferentially attack the predominant covalent α‐glycosyl triflate intermediate in an SN2‐like manner, while weak nucleophiles preferentially attack the less stable and more reactive β‐glycosyl triflate with H‐bond mediated direction. The first and facile synthesis of a hexasaccharide repeating unit of serotype IV group B Streptococcus capsular polysaccharide demonstrated the versatile utility of glucosyl building blocks with an oBCN functionality in carbohydrate chemistry.
Association of genetic variants and survival in patients with acute myeloid leukemia in rural Appalachia
Authors: Shultz Carl , Gates Christopher , Petros William , Ross Kelly , Veltri Laruen , Craig Michael , Wen Sijin , Primerano Donald A. , Hazlehurst Lori , Denvir James , Sdrimas Konstantinos 
Published: November 2022

AbstractBackgroundPrevious population health studies examining adults with acute myeloid leukemia (AML); however many of these, such as the Cancer Genome Atlas, are derived from databases collected by large urban centers. Due to its unique industry and environmental exposures, we hypothesized the West Virginia Appalachian population may have different mutational trends and clinical outcomes.AimsTo address the concern of under‐representation of rural minorities in cancer genomic databases, we performed exploratory whole exome sequencing in patients with newly diagnosed AML in rural Appalachia.Methods & ResultsCorrelations between genetic variants and clinical outcome variables were examined via retrospective chart review. A total of 26 patients were identified and whole exome sequencing was performed. Median age was 68 years old. Twenty‐one patients had de novo AML (84%). As per European LeukemiaNet (ELN) criteria, 8 patients were favorable (32%), 12 were intermediate (48%), and 5 were adverse risk (20%). Eight patients proceeded to transplant. The median progression‐free survival and overall survival were 16.5 months and 26.6 months, respectively. We noted an increased tumor mutation burden and a higher frequency of specific known driver mutations when compared to The Cancer Genome Atlas database; we also found novel mutations in MUC3A, MUC5AC, HCAR3, ORT2B, and PABPC. Survival outcomes were slightly lower than national average and BCOR mutation correlated with inferior outcomes.ConclusionOur findings provide novel insight into detrimental mutations in AML in a rural, underrepresented population. We discovered several novel mutations and higher frequency of some known driver mutations, which will help us identify therapeutic targets to improve patient outcomes.