bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nature or nurture: a latent ossification of the posterior longitudinal ligament after atlantoaxial fusion. Illustrative case
Authors: Tzeng Shih-Wei , Kuo Yi-Hsuan , Kuo Chao-Hung , Chang Hsuan-Kan , Ko Chin-Chu , Tu Tsung-Hsi , Chang Chih-Chang , Cheng Henrich , Huang Wen-Cheng , Wu Jau-Ching 
Published: August 2022

BACKGROUND
The natural history of ossification of the posterior longitudinal ligament (OPLL) remains poorly understood and multiple etiologies have been reported. However, most have focused on the characteristics of the patient rather than alternation of mechanical stress after spinal fusion.

OBSERVATIONS
This report describes, for the first time, a de novo OPLL found at the subaxial cervical spine 7 years after an atlantoaxial fusion surgery. A 57-year-old female initially required atlantoaxial arthrodesis for os odontoideum and stenosis that caused myelopathy. The posterior fusion surgery went smoothly without complications and the patient had good recovery of neurological functions. There was no associated instability, trauma, or reoperations during the follow-up. Seven years later, the patient presented with slight neck pain and a newly developed OPLL at C3–4 caudal to the C1–2 fusion construct.

LESSONS
Conflicting with the conventional concept that OPLL is common in elderly men with genetic or hormonal factors, or associated spondyloarthropathies, OPLL could develop in women even after solid C1–2 fusion. The adjacent subaxial cervical spine is not free of risks for subsequent development of OPLL and cervical spondylotic myelopathy. This case illustration extends the scope of etiologies of OPLL within the present literature.
HUBUNGAN GAYA HIDUP DAN POLA MAKAN TERHADAP KEJADIAN HIPERTENSI SELAMA MASA NEW NORMAL DITENGAH PANDEMI COVID 19
Authors: Efendi Zulham , Adha Dedi , Febriyanti Febriyanti 
Published: August 2022

Hipertensi merupakan salah satu penyakit tidak menular yang menjadi masalah kesehatan penting di seluruh dunia karena prevalensinya yang tinggi sebesar 22% pada kelompok usia ≥18 tahun pada tahun 2014 dan terus meningkat, serta hubungannya dengan penyakit kardiovaskuler, stroke, retinopati, dan penyakit ginjal. Hipertensi merupakan salah satu penyakit penyerta atau komorbiditas utama dari kasus positif dan kasus meninggal Covid-19. Berdasarkan data yang dikeluarkan Kementerian Kesehatan (Kemenkes) per kondisi 24 Juli 2020, Hipertensi menempati urutan pertama dari komorbiditas Covid 19. Sedangkan di Wilayah Kerja Puskesmas Ambacang Kuranji Padang ditemukan kasus selama masa new normal ditengah Pandemi COVID 19 tahun 2020 sebanyak 1.248 kasus. Tujuan penelitian ini adalah untuk mengetahui hubungan gaya hidup dan pola makan selama masa new normal di tengah pandemi covid 19 di Wilayah kerja Puskesmas Ambacang Kuranji Padang. Jenis Penelitian yang digunakan adalah non eksperimen dengan metode kuantitatif, desain menggunakan deskriptif corelational pendekatan cross sectional, dengan teknik pengambilan sampel purposive sampling. Pengolahan data dengan analisis data univariat dan bivariat dengan Chi-Square. Hasil penelitian terdapat tidak ada hubungan antara kejadian hipertensi dengan gaya hidup dan pola makan dengan nilai p-value > 0.05
Depresión, un trastorno que afecta a niños y adolescentes ¿Cuál fue su impacto durante el aislamiento por pandemia?
Authors: Vanegas Marcela 
Published: August 2022

En el presente trabajo se aborda el constructo de depresión basado en la etapa de la niñez y adolescencia, como así también en relación a ello, los diferentes estilos de afrontamientos. La información desarrollada, proviene de diversos informes científicos realizados, previos a la pandemia y durante la pandemia, en esta última etapa, cabe destacar que los trastornos como la depresión en el marco infanto juvenil, se ubicó entre los primeros resultados de las estadísticas.
ANALISA STRATEGI SISTEM INFORMASI MENGGUNAKAN PENDEKATAN METODESWOT DI BANDUNGINSIGHT
Authors: Yusman Nova Indrayana 
Published: August 2022

Bandung Insight is a company that has just been established in mid 2018, and has just begun in the field of information systems. For a new company, and of course there are still many shortcomings in various fields. And according to the observations of the author, the system that is used today is just working alternately, because it has not found the right information system that will be used in the future.In this system, data retrieval uses survey methods in collecting and processing information data to contain an overview of the situation in the object of the studies. As for the design of the information system, the author tries to use the SWOT analysis approach. Why? Because the reasoning of this system will be useful if its implementation is in accordance with the goals, vision and mission of the company by implementing information strategies and business strategies.
PENENTUAN SANTRI TELADAN MELALUI SISTEM PENDUKUNG KEPUTUSAN MENGGUNAKAN METODE PROFILE MATCHING (STUDI KASUS DI PONDOK PESANTREN AT-TAQWA CIREBON)
Authors: Alfian Shandy , Suarna Nana , Astuti Rini 
Published: August 2022

The education system in Islamic boarding schools is one way in which students will be selected as exemplary students and given awards annually. The selection process so far has not used a computerized assessment system, so that every part that requires assessment cannot quickly get an objective result in determining the assessment of the exemplary santri. The decision support system for the exemplary santri election was an alternative solution. This decision-making system can take into account all the criteria for selecting students quickly, easily in the data processing decision making process to determine the exemplary students. The method used in the design of this system uses the profile maching method through the PHP programming language and MySQL database. From this research the hypothesis p value (sig) 0,000 <0.5 and t-count (36,982> 1,699) t-table is obtained, so H0 is rejected, Ha is accepted. so it can be concluded that the profile matching method can make it easier to determine exemplary santri.
Pengaruh Kepemimpinan Transformasional dan Kompensasi terhadap Loyalitas Karyawan di Bank bjb Syariah KCP Majalaya
Authors: Fitriana Dewi Ratu , Rakhman Faisal , Dimyati Dadang 
Published: August 2022

The results of this study indicate that there is no significant influence between transformational leadership on employee loyalty at Bank BJB Syariah KCP Majalaya, with the results of the t-test where the value of tcount > ttabel (8,111 > 2,160), there is a significant effect between compensation on employee loyalty at Bank BJB Syariah KCP Majalaya with the result of the t-test where the value of tcount > ttabel (6,460 > 2,160) and simultaneously there is a significant influence between transformational leadership and compensation on employee loyalty with the result of the F-test, namely Fcount > Ftabel (32,302 > 3,74).
Sistem Informasi Pembayaran Rumah Kost Berbasis Website pada Elin Kost Garut
Authors: Rosliani Elin Rosliani , Fahmidin Cecep , Nurul Ikrimah 
Published: August 2022

Increasing technological developments can be utilized properly through various systems. However, some managers and prospective tenants of boarding house rental businesses will still have difficulty in having an integrated system. Many of them still make reservations for boarding houses directly at the location where the boarding house is located and there is limited information about the types and facilities of the rooms available. Elin Kost is one of the many boarding houses in Garut Regency that have not used the internet as a transaction medium in it. In making room reservation transactions, payments are made manually without using the internet, making it difficult for boarding house residents to view payment transaction history. The information system development method used is the waterfall method, namely needs analysis, system design, implementation, testing & testing, and uses SWOT analysis (Strength, Weakness, Opportunities, Threats) to find the source of the problem. Data collection methods are observation and literature study. The results showed that the application of a payment information system was able to help increase Elin Kost sales because it facilitated the payment process. In addition, there is a need for development in the system so that it can provide more satisfying services to users.
Problematika Anak Tidak Sekolah (ATS) sebagai Faktor Pemicu Kemiskinan Ekstrim dan Stunting
Authors: Kurniawan Rizqi Hary , Lestari Eka Sefia , Azizi Sofian Ahmad , Pranoto Tri Aji , Aza Muhammad Adrokal , Fuad Fuad , Latifah Siti , Kustiana Melda , Mubaroh Saniatul , Aulia Lana Syifa , Lestiyanawati Rochyani 
Published: August 2022

Problematika Anak Tidak Sekolah (ATS) sebagai salah satu faktor pemicu Kemiskinan Ekstrim dan Stunting merupakan bagian yang perlu dibahas dimana ini merupakan contoh yang bisa secara gamblang dirasakan dampaknya dari sisi Pendidikan untuk kepentingan Ekonomi dan juga Kesehatan. Adanya problematika anak tidak sekolah (ATS) ini baik karena faktor ekonomi, moral, dan penyebab lainnya harus benar-benar diperhatikan tidak hanya oleh Pemerintahan tetapi juga oleh Masyarakat itu sendiri sehingga pemicu dari Kemiskinan Ekstrim maupun Stunting ini dapat dicegah sedini mungkin. Fakta ini didapatkan dari hasil Verval Pendataan Anak Tidak Sekolah (ATS) pada tahun 2022, yang terlaksana selama masa Kuliah Pengabdian Masyarakat di Desa Jengkol, Kecamatan Garung, Kabupaten Wonosobo. Verval dilakukan dengan Pengumpulan Data Anak Usia 7-18 tahun di Desa Jengkol, mengidentifikasi Status Anak Tidak Sekolah (ATS), dan dieksekusi dengan interview secara langsung dengan Responden, dan dari data-data yang dikumpulkan didapatkan fakta-fakta yang nantinya bisa menjadi modal dalam penanganan Anak Tidak Sekolah (ATS) sebagai bentuk penanggulangan Kemiskinan Ekstrim dan Stunting.
Strategi Penanggulangan Dampak Pandemi pada Kondisi Sosio-Ekonomi dan Pendidikan di Desa Tambak Cemandi, Sedati, Sidoarjo
Authors: Aulia Fa'iqotur , Yudha Ana Toni Roby Candra , Dharmawan Ferry , Saputra Gery Akbar , Wahid Muhammad Ilham , Rosidhah Nafi Ngatur 
Published: August 2022

Adanya COVID 19 menyebabkan banyak dampak pada segala aspek, termasuk ekonomi, sosial dan pendidikan. Hal itu terjadi dan dirasakan oleh semua wilayah di Indonesia, tidak tercuali Desa Tambak Cemandi, Sidoarjo. Tujuan studi ini adalah untuk memberikan alternatif model strategi dalam meredakan permasalahan akibat pandemi COVID 19. Metode yang digunakan adalah kualitatif fenomenologi, yaitu melalui proses penggalian data, mengkaji, dan interaksi sosial selama 1 bulan bersama masyarakat setempat. Hasil studi yang didapatkan adalah adanya tren penurunan kualitas ekonomi dalam hal daya beli, peluang kerja, pendapatan dan konsumsi selama masa pandemi COVID 19. Hal ini terlihat dari penurunan aktivitas melaut dan tangkapan yang diperoleh. Atas hal tersebut maka, perlu adanya strategi penaggulangan dampak bantuan informasi dengan mencarikan calon pembeli atau konsumen dengan melibatkan semua pemangku kepentingan di daerah Desa Tambak Cemandi. Sehingga saran yang bersesuaian dengan hasil tersebut adalah perlu adanya kerjasama berkesinambungan dengan perangkat desa setempat agar mendapat perhatian dan alternatif cara untuk menjual hasil tangkapan lautnya.
Clinician communication strategies associated with increased uptake of the human papillomavirus (HPV) vaccine: A systematic review
Authors: Constable Catherine , Ferguson Kyle , Nicholson Joey , Quinn Gwendolyn P. 
Published: August 2022

AbstractHuman papillomavirus (HPV) is currently linked to almost 35,000 new cases of cancer in women and men each year in the United States. Gardasil‐9 (Merck & Company), the only HPV vaccine now available in the United States, is nearly 100% effective at preventing precancers caused by oncogenic HPV types. In the United States, however, only about one half of adolescents are up to date with HPV vaccination. It is well known that health care clinicians’ recommendations play a significant role in parents’ decisions regarding HPV vaccination. A growing body of literature examines specific communication strategies for promoting uptake of the HPV vaccine. A comprehensive review of the evidence for each of these strategies is needed. The authors searched the PubMed, EMBASE, Cochrane Central Register of Controlled Trials, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, and Web of Science Complete databases for original articles with a defined clinician communication strategy and an outcome of HPV vaccine uptake or intention to vaccinate (PROSPERO registry no. CRD42020107602). In total, 46 studies were included. The authors identified two main strategies with strong evidence supporting their positive impact on vaccine uptake: strong recommendation and presumptive recommendation. Determinations about a causal relationship were limited by the small numbers of randomized controlled trials. There is also opportunity for more research to determine the effects of motivational interviewing and cancer‐prevention messaging.
PROPOSED IMPROVEMENT OF FAJAR DAILY NEWSPAPER PRODUCTS WITH A SIX SIGMA APPROACH
Authors: Syamsul Nadzirah Ikasari , Amar Kifayah , Bahri Syamsul , Mansur Mario Alif 
Published: August 2022

In Indonesia, many manufacturing industry companies large and small are trying to make products of good quality to the market. This is because only companies that have good product quality can compete and survive. PT. Fajar Makassar Grafika is a subsidiary of Fajar Group that specifically handles newspaper printing production, in carrying out the process of newspaper production there are still many problems with product defects that are not by the standards of the company.The method used in this study is the Six sigma method using DMAIC stages (define, measure, analyze, improve and control). Six Sigma is one of the tools commonly used in product quality control. This method has the concept of setting quality standards until it reaches 3.4 rejects per one million possibilities.Based on the results of analysis with the Six Sigma method it has been known that in the production process there are 5 types of defects, namely blurred mold defects, dirty prints, not registers, folded and torn newspapers with sigma levels obtained at 3.92 with an average damage rate of 7760 for one million productions (DPMO). From the analysis of fishbone diagrams can be known the causal factors of defective products derived from machine, material and human factors. The proposed improvement is done using Failure Mode and Effect Analysis (FMEA) analysis, so that the company can take precautions and improvements to reduce defective products and improve product quality
Changes in stiffness of the specific regions of knee extensor mechanism after static stretching
Authors: Zhu Yuanchun , Feng Yanan , Huang Fangchao , Li Yapeng , Wang Wenjing , Wang Xueqiang , Cao Xiangyang , Zhang Zhijie 
Published: August 2022

Decreased muscle stiffness could reduce musculotendinous injury risk in sports and rehabilitation settings. Static stretching (SS) has been used to increase the flexibility of muscles and reduce muscle stiffness, but the effects of SS on the stiffness of specific regions of the knee extensor mechanism are unclear. The quadriceps femoris and patellar tendon are essential components of the knee extensor mechanism and play an important role in knee motion. Therefore, we explored the acute and prolonged effects of SS on the stiffness of the quadriceps femoris and patellar tendon and knee flexion range of motion (ROM). Thirty healthy male subjects participated in the study. Three 60-s SS with 30-s intervals were conducted in right knee flexion with 30° hip extension. We measured the ROM and stiffness of the vastus medialis (VM), vastus lateralis (VL), and rectus femoris (RF) and the proximal-(PPT), middle-(MPT), and distal-(DPT) region stiffness of the patellar tendon before and immediately after SS intervention, or 5 and 10 min after SS. The stiffness of the quadriceps muscle and patellar tendon were measured using MyotonPRO, and the knee flexion ROM was evaluated using a medical goniometer. Our outcomes showed that the ROM was increased after SS intervention in all-time conditions (p &lt; 0.01). Additionally, the results showed that the stiffness of RF (p &lt; 0.01) and PPT (p = 0.03) were decreased immediately after SS intervention. These results suggested that SS intervention could be useful to increase knee flexion ROM and temporarily reduce the stiffness of specific regions of the knee extensor mechanism.
Baduanjin exercise in the treatment of hypertension: A systematic review and meta-analysis
Authors: Ma Zhen , Lei Honghui , Tian Kexin , Liu ZhiZe , Chen Ying , Yang Haoqi , Zhu Xiangyu 
Published: August 2022

BackgroundAs a therapy to prevent and treat hypertension, exercise is widely used in clinical practice. But due to the lack of documentary evidence, Baduanjin as a relaxed and convenient mode of exercise is not currently recommended by professional health organizations to treat hypertension. The purpose of this article is to examine the efficacy of Baduanjin as an antihypertensive exercise therapy.MethodsOur systematic retrieved of the entire relevant literatures in 12 databases. Finally, 28 eligible trials involving Baduanjin intervention in hypertension were included. After the quality assessment and bias risk assessment of the included trials, we analyzed the blood pressure values before and after the intervention, and performed meta-analysis on the random effect results. In order to explore the factors influencing the decrease of blood pressure, we also performed a subgroup analysis of the results.ResultsParticipants (n = 2121) were adults (61.74 ± 5.85years of age, mean ± SD), with baseline blood pressure (systolic blood pressure (SBP) = 150.7 ± 9.2 mmHg, diastolic blood pressure (DBP) = 93.2 ± 8.8 mmHg). Baduanjin was practiced 7.5 ± 3.8 sessions / week for 28.2 ± 12.8 min /session for 16.7 ± 9.2 weeks. Overall, Baduanjin resulted in SBP (−9.3 mmHg, d = −1.49, 95%CI: −1.73 to −1.13) and DBP (−6.3 mmHg, d = −1.20, 95%CI: −1.51 to −0.88) vs. the control group (p &lt; 0.001). After a subgroup analysis of age, we found that SBP heterogeneity was significantly reduced in the elderly group.ConclusionOur results indicate that Baduanjin can effectively reduce blood pressure (i.e., 9.3 mmHg and 6.3 mmHg of SBP and DBP reductions, respectively), and reduce the incidence rate of cardiovascular disease in hypertensive patients. In addition, we will be more likely to recommend that the elderly exercise Baduanjin.
Association of FLG mutation with tumor mutation load and clinical outcomes in patients with gastric cancer
Authors: Yicheng Fu , Xin Liu , Tian Yu , Huilin Liu 
Published: August 2022

Background: Stomach adenocarcinoma (STAD) is one of the most frequently diagnosed cancers in the world with a poor prognosis due to genetic heterogeneity. The present study aimed to explore potential prognostic predictors and therapeutic targets that can be used for STAD treatment.Methods: We collected relevant data of STAD patients from the Cancer Genome Atlas (TCGA), including somatic mutation, transcriptome, and survival data. We performed a series of analyses such as tumor mutational burden (TMB), immune infiltration, and copy number variation (CNV) analysis to evaluate the potential mechanism of filaggrin (FLG) mutation in gastric cancer. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and gene set enrichment analysis (GSEA) were performed for annotation of differentially expressed genes (DEGs). The STRING online database was used to construct the protein–protein interaction (PPI) and ceRNA network and hub genes were identified. Univariate and multivariate Cox regression analyses were used to determine the effect of selected DEGs on tumor prognosis.Results: The FLG-mutant group (FLG-MT) showed a higher mutation load and immunogenicity in gastric cancer. GO and KEGG analyses identified and ranked unique biologic processes and immune-related pathway maps that correlated with the FLG-mutant target. GSEA analysis showed that several tumorigenesis and metastasis-related pathways were indeed enriched in FLG-mutant tumor tissue. Both cell cycle–related pathways and the DNA damage and repair associated pathways were also enriched in the FLG-MT group. The FLG mutations resulted in increased gastric cancer sensitivity to 24 chemotherapeutic drugs. The ceRNA network was established using Cytoscape and the PPI network was established in the STRING database. The results of the prognostic information further demonstrated that the OS and DFS were significantly higher in FLG mutation carriers, and the FLG gene mutation might be a protective factor.Conclusion: The multiple molecular mechanisms of the FLG gene in STAD are worthy of further investigation and may reveal novel therapeutic targets and biomarkers for STAD treatment.
Prognosis analysis of necroptosis-related genes in colorectal cancer based on bioinformatic analysis
Authors: Liang Xiaojie , Cheng Zhaoxiang , Chen Xinhao , Li Jun 
Published: August 2022

Background: Colorectal cancer (CRC) is one gastrointestinal malignancy, accounting for 10% of cancer diagnoses and cancer-related deaths worldwide each year. Therefore, it is urgent to identify genes involved in CRC predicting the prognosis.Methods: CRC’s data were acquired from the Gene Expression Omnibus (GEO) database (GSE39582 and GSE41258 datasets) and The Cancer Genome Atlas (TCGA) database. The differentially expressed necroptosis-related genes (DENRGs) were sorted out between tumor and normal tissues. Univariate Cox regression analysis and least absolute shrinkage and selectionator operator (LASSO) analysis were applied to selected DENRGs concerning patients’ overall survival and to construct a prognostic biomarker. The effectiveness of this biomarker was assessed by the Kaplan–Meier curve and the receiver operating characteristic (ROC) analysis. The GSE39582 dataset was utilized as external validation for the prognostic signature. Moreover, using univariate and multivariate Cox regression analyses, independent prognostic factors were identified to construct a prognostic nomogram. Next, signaling pathways regulated by the signature were explored through the gene set enrichment analysis (GSEA). The single sample gene set enrichment analysis (ssGSEA) algorithm and tumor immune dysfunction and exclusion (TIDE) were used to explore immune correlation in the two groups, high-risk and low-risk ones. Finally, prognostic genes’ expression was examined in the GSE41258 dataset.Results: In total, 27 DENRGs were filtered, and a necroptosis-related prognostic signature based on 6 DENRGs was constructed, which may better understand the overall survival (OS) of CRC. The Kaplan–Meier curve manifested the effectiveness of the prognostic signature, and the ROC curve showed the same result. In addition, univariate and multivariate Cox regression analyses revealed that age, pathology T, and risk score were independent prognostic factors, and a nomogram was established. Furthermore, the prognostic signature was most significantly associated with the apoptosis pathway. Meanwhile, 24 immune cells represented significant differences between two groups, like the activated B cell. Furthermore, 32 immune checkpoints, TIDE scores, PD-L1 scores, and T-cell exclusion scores were significantly different between the two groups. Finally, a 6-gene prognostic signature represented different expression levels between tumor and normal samples significantly in the GSE41258 dataset.Conclusion: Our study established a signature including 6 genes and a prognostic nomogram that could significantly assess the prognosis of patients with CRC.