bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tobacco Consumption Patterns among Iranian Adults: a National and Sub-national Update from the STEPS Survey 2021
Authors: Abbasi-Kangevari Mohsen , Ghanbari Ali , Malekpour Mohammad-Reza , Masinaei Masoud , Ahmadi Naser , Ghamari Seyyed-Hadi , Naderian Mohammadreza , Fattahi Nima , Rashidi Mohammad-Mahdi , Maleki Ali , Abbasi-Kangevari Zeinab , Rezaei Nazila , Mehr Elmira Foroutan , Moghimi Mana , Rezaei Negar , Farzadfar Farshad 
Published: November 2022

Abstract

Background and objective

Smoking is recognised as a critical public health priority due to its enormous health and economic consequences. Constant monitoring of the effectiveness of tobacco control programs calls for timely population-based data. This study reports the national and sub-national patterns in tobacco consumption among Iranian adults based on the results from the STEPwise approach to chronic disease risk factor surveillance (STEPS) survey 2021.

Methods

This study was performed through an analysis of the results of the STEPS survey 2021 which had been conducted as a nationally representative cross-sectional study. Participants included Iranian adults aged ≥ 18 years in all provinces of Iran, who were selected via multistage cluster sampling method. Data were analyzed via survey analysis while considering population weights.

Results

The total number of participants was 27874, including 15395 (55.23%) women and 12479 (44.77%) men. The all-ages prevalence (95% CI) of current tobacco smoking was 14.01% (13.56–14.48): 4.44% (4.09–4.82) among women and 25.88% (25.03–26.75) among men. The all-ages prevalence of current cigarette smoking was 9.33% (8.95–9.72): 0.77% (0.62–0.95) among women and 19.95% (19.17–20.75) among men. The all-ages prevalence of current hookah smoking was 4.5% (4.23–4.78): 3.64% (3.33, 3.98) among women and 5.56% (5.12–6.03) among men. The mean (SD) number of cigarettes smoked per day among current cigarettes smokers was 11.4 (9.82): 5.9 (6.76) among women and 11.65 (9.87) among men. The mean (SD) monthly times of hookah use was 23.87 (44.95): 29.93 (48.26) among women and 19.02 (41.52) among men. The national all-ages prevalence of second-hand smoking at home was 24.65 (24.06–25.25): 27.39 (26.6-28.19) among women and 20.28 (19.4-21.18) among men. The national all-ages prevalence of second-hand smoking at work was 20.73% (20.11–21.36): 17.96% (17.21–18.73) among women and 25.15% (24.07–26.26) among men.

Conclusion

The tobacco consumption in Iran remains alarmingly high, indicating the current tobacco control policy implementation level is ineffective and insufficient. This calls for adopting, implementing, and enforcing comprehensive packages of evidence-based tobacco control policies.
Compound heterozygous mutations in the TPP1 gene causes the rare Autosomal recessive spinocerebellar ataxia type 7 : A case report and review
Authors: Wang Xinyu , Wang Xingchen , Jia Yuanyuan , Liu Ruihan , Xia Min , Nie Qiong , Kong Qingxia 
Published: November 2022

Abstract
Background: Spinocerebellar ataxia type (SCA) type 7 is an inherited neurological disorder that can be inherited as autosomal dominant, autosomal recessive, X-linked, or mitochondrial. In clinical practice, the most common type of SCA7 is autosomal dominant, and the autosomal recessive spinocerebellar ataxia 7 (SCAR7) has been rarely reported. Here, we report the first case of SCAR7 from China with compound heterozygous missense mutations in the Tripeptidyl peptidase-I (TPP1) gene.
Case presentation: A 25-year-old female patient presented with difficulty in walking, easy falling, accompanied by limb shaking, unstable holding objects, slurred speech, choking and coughing when drinking water, palpitations, easy hunger, and hyper-eating without obvious causes 12 years ago. She was admitted to a tertiary general hospital for a cranial MRI examination, which showed cerebellar atrophy. The patient had dysarthria, and had horizontal nystagmus in both eyes for left vision. She was not stable and precise enough in the bilateral finger-nose test and heel and knee shin test and showed Romberg's sign (+). Wechsler Adult intelligence test suggested mild intelligence defect. Genetic testing showed that there were two compound heterozygous mutations in the TPP1 gene. The patient was diagnosed as SCAR7.
Conclusions: The results of autosome testing and sequencing showed that the SCAR7 case was caused by compound heterozygous mutations of the TPP1 gene (c.1468G>A p.Glu490Lys and c.1417G>A p.Gly473Ary). This mutation has not been reported in the Chinese population and is a rare novel mutation. This finding provides a new starting point for the study of the SCAR7 gene.
Constructing of a scientific fitness literacy evaluation model for adults
Authors: Zhang Yanfeng , Gao Yibo , Deng Pengyu , Wang Huan , Wu Dongming , Fu Jinmei , Zhang Fuhong , NAITO Hisashi , Lin Sen , Pan Xiang , Jiang Lupei , Zhao Shuangying , Zhang Aoyu , He Jin 
Published: November 2022

Abstract
COVID-19-associated lockdown has been implemented worldwide, potentially causing unfavorable changes in lifestyle and psychological health. Physical literacy, healthy diets, and lifestyles play important roles in mitigating the adverse effects. Therefore, this study aimed to enable individuals to understand their fitness literacy and establish a personalized exercise plan.
In this study, 903 adults aged 19－59 were surveyed based on the concept of scientific fitness literacy and the influencing factors in the context of the effective containment of COVID-19 before (2019) and during (2020) the pandemic. This study screened four factors from four dimensions–cognition, attitude, ability and skills, and behavior and habits–that can influence adults' scientific fitness literacy. Confirmatory factor analysis (CFA) and AMOS software were used to construct an evaluation index system of scientific fitness literacy for adults.
The model consisting 10 items with 4 factors to evaluation index system has good overall fitness, reliability, convergent validity, differential validity, and model stability and was able to analyze the factors that affect the scientific fitness literacy of individuals from different perspectives. This allowed individuals at different stages to have a deeper understanding of scientific fitness literacy.
Factors affecting pharmacists’ capacity to deliver pharmacy service in community pharmacies using Zhengzhou, China, as an example
Authors: Meng Wenxin , Wang Yanan , Shen Jian , Yan Mingxun , Hu Yuanjia , Jiang Rong 
Published: November 2022

Abstract
Background
This paper analyzed the factors influencing capacity to deliver pharmacy service, which had great significance in improving pharmacy service level and promoting people’s drug safety. This paper aimed to explore the relationship between ability of pharmacy service and income, career prospects, job satisfaction, cumulative hours of continuing education, and awareness of the need for continuing education among pharmacists in Zhengzhou community pharmacy based on the principal component regression analysis.
Methods
Through the random sampling method, a total of 124 pharmacists participated in the questionnaire survey. Principal component analysis was used to eliminate the correlation between factors. Regression analysis was used to study the influencing relationship between capacity of pharmacy service and the related factors.
Results
This study extracted two principal components, with a cumulative variance contribution rate of 56.604%. Further analysis revealed that cumulative hours of continuing education (0.1178), job satisfaction (0.0783), career prospects (0.042), awareness of the need for continuing education (0.0358), and income (0.0067) all had a positive impact on pharmacists’ abilities in pharmacy service. Among them, the degree of their influence gradually decreased.
Conclusion
To enhance pharmacists’ capacity to provide pharmacy service in community pharmacies, on the one hand, continuing education should be further strengthened to enhance pharmacists’ professionalism. On the other hand, the government should broaden their career prospects, improve their career treatment, and increase their job satisfaction, ultimately enhancing their capabilities to deliver pharmacy service.
Validation and Cultural Adaptation of a Greek Version of Pediatric Eating Assessment Tool 10 (Pedi – EAT – 10) in Greek-Cypriot Parents
Authors: Georgiou Rafaella , Papaleontiou Andri , Voniati Louiza , Siafaka Vasiliki , Ziavra Nafsika , Tafiadis Dionysios 
Published: November 2022

Abstract

Purpose:The Pediatric Eating Assessment Tool (Pedi - EAT - 10) is a clinical screening tool that has been designed to assess pediatric patients at risk of penetration and/or aspiration symptoms of dysphagia, reported by parents or caregivers. The aim of this study was to translate and validate Pedi-EAT-10 in Greek language and to correlate its results with the Penetration and Aspiration scale (PAS) and pharyngeal residue.
Methods: This study included sample of 222 parents or caregivers who have children with and without feeding and/or swallowing disorders. The children were randomly selected from cypriot public school, cypriot special public school, and the Speech, Language, and Hearing clinic of the European University of Cyprus; the children’s parents filled out the Pedi-EAΤ-10 questionnaire. For test-retest reliability, all participants administered the Pedi-EAT-10 again once more 2 weeks after the initial administration.
Results: Validity was established by comparing the scores of children with and without feeding and/or swallowing disorders. Internal consistency of Pedi-EAT-10 was high (Cronbach's alpha 0.801). The split-half reliability technique demonstrated very good Pedi-EAT-10 internal consistency (split-half reliability coefficient = 0.789). A test-retest reliability measure showed strong correlation (r= 0.998). The cut-off point of Pedi-EAT-10 total score and PAS scale was 11.00. Finally, Pedi-EAT-10 total score in predicting pharyngeal residue observed a cut-off of 8.00.
Conclusion:In conclusion, the Greek version of Pedi-EAT-10 is shown to be a clinically valid and reliable screening tool for the assessment of the pediatric population with a risk of dysphagia.
WITHDRAWN: SHOX variations in Idiopathic Short Stature in North India and its overall prevalence in Asia
Authors: Srivast Priyanka 
Published: November 2022

Abstract
Background
Short stature homeobox (SHOX) haploinsufficiency underlies idiopathic short stature (ISS) and Leri-Weill dyschondrosteosis (LWD). The worldwide prevalence of SHOX variations in ISS varies from 2.5–15%. This study aims to assess the implication of SHOX variation in ISS in North India and its overall prevalence in Asian population.
Methods
SHOX gene analysis carried out by Multiplex ligation dependent probe amplification (MLPA) followed by Sanger sequencing in 54 patients with variable phenotypes. Meta-analysis was done to evaluate its prevalence which comprises 11 previous studies including present, carried out on a total of 979 participants.
Results
SHOX gene analysis resulted in 12.9% of positivity (7.4% deletions and 5.5% duplications). SHOX association was seen significantly related to gender, with predominance in female sex (P-value: 0.047). Short arms and forearms were the only significantly associated trait seen in 51.85% of children. We have found a rare association of multiple exostosis with LWD in a child with deletion. The prevalence of SHOX variation came as 15.2% in Asians. No significant difference was found in geographical region-specific analysis.
Conclusion
This meta-analysis compiles findings from the last decade and provides an updated picture of the prevalence of SHOX variations in Asians, emphasizing their potential as therapeutic targets in ISS patients.
Synthesis of ZnxNi1-xFe2O4, MnxNi1-xFe2O4, MgxNi1-xFe2O4, CuxNi1-xFe2O4 and CaxNi1-xFe2O4 via co-precipitation method and their application for treatment of textile wastewater
Authors: Fatima Laiba , Munir Ruba , Noreen Saima , Ali Khuram 
Published: November 2022

Abstract
The discharge of synthetic dyes imparting serious consequences on life. Therefore, an environment-friendly co-precipitation method was utilized to prepare the nanocomposites of doped Nickel ferrite as novel adsorbents for eradication of DB-199 dye. The maximum pH for synthesized ZnxNi1-xFe2O4, MnxNi1-xFe2O4, MgxNi1-xFe2O4, CuxNi1-xFe2O4 and CaxNi1-xFe2O4 were reported to be 2 and 3 with 0.05 g/50 mL maximum adsorbent dosage of synthesized doped Nickel ferrite respectively. The optimum contact time was found at 60 min and 45 min. The maximum initial concentration of DB-199 Dye and the respective adsorption capacity for ZnxNi1-xFe2O4, MnxNi1-xFe2O4, MgxNi1-xFe2O4, CuxNi1-xFe2O4, and CaxNi1-xFe2O4 was found 50 mg L1- (33.169 mg g1-), 75 mg L1- (48.610 mg g1-), 75 mg L1- (46.657 mg g1-), 50 mg L1- (31.150 mg g1-) and 75 mg L1- (44.840 mg g1-) were acquired. All the adsorbents ZnxNi1-xFe2O4, MnxNi1-xFe2O4, MgxNi1-xFe2O4, CuxNi1-xFe2O4, and CaxNi1-xFe2O4 showed their optimum absorption 32.833 mg g1-, 38.892 mg g1-, 36.939 mg g1-, 30.880 mg g1- and 34.852 mg g1- respectively at 30 ºC. Among the applied Kinetics models, pseudo-first-order and pseudo-second-order while isotherm models, Langmuir and D-R models showed satisfactory fitness. The adsorption process for doped nickel ferrite nanoparticles was found to be exothermic in nature.
Effect of basic amino acid pretreatment on the quality of canned Antarctic krill
Authors: Sun Peizi , Zhang Xuedi , Ren Xiang , Cao Zhiqi , Zhao Yanfen , Man Hao , Li Dongmei 
Published: November 2022

Abstract
Antarctic krill (Euphausia Superba) has a high nutritional value; however, due to its autolysis characteristics and easy deterioration characteristics after heating, which leads to difficulties in processing, canned Antarctic krill is one of the few products that exist. However, canned Antarctic krill have a rough taste, high hardness, and poor palatability. Therefore, there is a need to improve its quality. In recent years, the good performance of basic amino acids as a Phosphate-free additives in improving the product quality of foods has indicated their broad application prospect. The purpose of this study was to evaluate the effect of basic amino acid (L-arginine (Arg), L-lysine (Lys), and L-histidine (His)) pretreatment on enhancing the quality of canned Antarctic krill. Low-field nuclear magnetic resonance, magnetic resonance imaging, and textural profile analyses, color, scanning electron microscopy, thiobarbituric acid reaction substances (TBARS), pH, and sensory evaluation were used to determine the indices of krill meat at different pretreatment conditions and processing stages. The results showed that compared to the sodium tripolyphosphate pretreatment group, krill meat pretreated with Lys had a larger peak area of immobile water, higher pseudo-color image brightness after sterilization of krill meat, a more complete microstructure network. Additionally, it had the best water-holding capacity, lower hardness and TBARS values, and significantly higher a* values, indicating that Lys effectively improved the texture and color of krill, protecting the microstructure, and reducing the degree of oxidation. Sensory evaluation results showed that the Lys-treated canned Antarctic krill had a better flavor and texture compared to other canned products. The results of this study suggest that Lys can provide a regulatory strategy for effectively enhancing the quality of canned Antarctic krill.
Impacts of Climate Change Impacts on the Biogeography of three Amnesic Shellfish Toxin-producing Diatom species
Authors: Borges Francisco O. , Lopes Vanessa M. , Santos Catarina Frazão , Costa Pedro Reis , Rosa Rui 
Published: November 2022

Abstract
Harmful algal blooms (HABs) are considered one of the main risks for marine ecosystems and human health worldwide. Climate change is projected to induce significant changes to species geographic distribution, and, in this sense, it is paramount to accurately predict how it will affect toxin-producing microalgae. In this context, the present study intends to project the potential biogeographical changes in habitat suitability and occurrence distribution of three key amnesic shellfish toxin (AST)-producing diatom species (i.e., Pseudo-nitzschia australis, P. seriata, and P. fraudulenta) under four different climate change scenarios (i.e., RCP-2.6, 4.5, 6.0, and 8.5) and up to 2050 and 2100. For this purpose, we applied species distribution models (SDMs) using four abiotic predictors (i.e., sea surface temperature, salinity, current velocity, and bathymetry), in a MaxEnt framework. Overall, considerable contraction and potential extirpation was projected for all species at lower latitudes, together with projected poleward expansions into higher latitudes, mainly in the northern hemisphere. The present study aims to contribute to further the knowledge on the impacts of climate change on the biogeography of toxin-producing microalgae species, while at the same time advising towards the correct environmental management of coastal habitats and ecosystems.
FOEH: Frequent Pattern Mining Performance Optimization over Large Transactional Data in Extended Hadoop MapReduce
Authors: S Guru Prasad M , N Naveen Kumar H , Shah Mohd Asif , K Raju , K Santhosh Kumar D , S Chandrappa 
Published: November 2022

Abstract
Frequent item mining is a process wherein we extract or mine frequent itemsets from a given input dataset. Apriori algorithms and FP-growth algorithms are two types of common pattern mining algorithms. Traditional implementations of such frequent item mining algorithms tend to be inefficient when it comes to mining frequent item sets over large transactional datasets, owing to the fact that they consume a greater amount of time in performing the same. In order to tackle the issues mentioned, large transaction datasets using the extended Hadoop MapReduce Framework are considered. On the same, a novel distributed, parallel processing, frequent item mining algorithm is integrated. The analysis of the performance of the implemented algorithm proves that the performance of frequent item analysis in relation to data uploading time, HDFS disk utilization, and data processing time has improved drastically.
Identification of Iron Metabolism-Related Gene Signatures for Predicting the Prognosis of Patients with Skin Cutaneous Melanoma
Authors: Guo Yuchen , Song Chuanjun , Zhang Lianghui , Han Zhihang , Zhu Lingjun 
Published: November 2022

Abstract
Background
Skin cutaneous melanoma (SKCM) is an aggressive form of skin cancer with an elevated risk of metastasis and high mortality rates. Current immunotherapies represented by immune checkpoint inhibitors (ICI), such as anti-CTLA-4 and anti-PD-1/L1, have achieved remarkable durable responses in SKCM treatment. Recent studies have highlighted the biological significance of iron metabolism modification in tumorigenicity and progression. However, there has been insufficient evidence to reveal the prognostic value of iron metabolism-related genes (IMRGs) in SKCM and its relationship with the immune microenvironment and the efficacy of immunotherapy.
Methods
In this study, we curated 85 iron metabolism-related genes and performed unsupervised consensus analysis to identify iron metabolism modification patterns and the IMRG signature in SKCM. We used the ssGSEA algorithms to quantify the infiltration levels of various immune cells. An IMRG scoring scheme based on the PCA algorithm was used to evaluate the iron metabolism modification patterns of individual tumors.
Results
We identified three distinct iron metabolism modification patterns among 685 SKCM samples, which were associated with different prognoses and biological pathways. Meanwhile, three distinct iron metabolism modification patterns of SKCM had different immune cell infiltration. Based on the IMRG score, SKCM patients can be divided into high and low score subgroups. Multivariate Cox regression analysis showed that the IMRG score was an independent prognostic indicator. It was concluded that patients with lower IMRG scores had prolonged survival time. We further proved that a lower IMRG score was correlated with PD-L1, PD-1, CTLA4 expression, and better immune responses.
Conclusions
Our study highlights that iron metabolism is significantly associated with prognosis and immune cell infiltration. What’s more, this analysis of different IMRG patterns in SKCM patients contributed to a deeper understanding of TME and provided new perspectives for predicting prognosis and designing individualized immunotherapy strategies for SKCM patients.
Investing in student wellbeing: A design-based educational research approach to develop a longitudinal proactive program to improve wellbeing of medical students
Authors: Hameleers Ron J.M.G. , Terlouw A. Jasmijn , Laan Roland F.J.M. , de Pol Marjolein H.J. van 
Published: November 2022

Abstract
Background
Many medical students suffer from psychosocial distress and mental health problems, raising concerns about their sustainable employability and subjective wellbeing. Therefore, our faculty decided to design a wellbeing program building on the paradigm that in order to sustainably take care of others and deliver high-quality and safe patient care, (future) health professionals should take care of their own wellbeing first. The aim of our research was to design a theory-informed program on student wellbeing allowing students to acquire skills in this regard. In this paper, we describe the iterative design process and the results of our longitudinal proactive wellbeing program.
Methods
We conducted an educational design approach in four phases to construct the program in order to simultaneously gain new insights and develop practical solutions. We implemented the phases of educational design research over the course of two academic years. Phase 1 consisted of a review of the literature and a context and needs analysis in order to draft design principles and requirements. Phase 2 consisted of the cyclical and iterative process of design, construction and interim evaluation and adjustments of the wellbeing program (WB-program). In phase 3, evaluation and reflection, the program was implemented and evaluated. Phase 4 consisted of ongoing maturation and theoretical understanding of the program.
Results
With our educational design-based approach to construct a WB-program, we were able to design, construct and evaluate an evidence-informed longitudinal proactive wellbeing program for all bachelor of medicine students at our faculty. The most noteworthy result thus far is that students who are exposed to a longitudinal program with recurring attention on improving and maintaining wellbeing learn to value the importance of self-care and wellbeing and develop skills in this regard.
Conclusion
Taken together, our study suggests that it is possible to integrate wellbeing in a core undergraduate curriculum on a large scale. We therefore consider the results of this educational design-based development of our WB-program as a proof of concept for a longitudinal integrated program to support student wellbeing.