bluuebunny/crossref_metadata_2025_split huggingface dataset:
The epidemiology of rare types of hepatobiliary and pancreatic cancer from national cancer registry
Authors: Satake Tomoyuki , Morizane Chigusa , Rikitake Ryoko , Higashi Takahiro , Okusaka Takuji , Kawai Akira 
Published: September 2022

Abstract
Background
Information on rare hepatobiliary and pancreatic (HBP) subtypes of cancer is scarce. We aimed to elucidate the incidence and clinical features of rare tumors in Japan using the National Cancer Registry (NCR), a new nationwide integrated population-based registry.

Methods
The data of patients diagnosed in 2016–2017 were extracted from the NCR database, and classified by topography: liver cells, intrahepatic bile duct, gallbladder, extrahepatic bile duct, ampulla of Vater, and pancreas. Data were described and analyzed using the World Health Organization and General Rules tumor classifications. The incidences for all rare tumors including hepatoblastoma and adenosquamous cell carcinoma were calculated as the number of new cases divided by the corresponding total person years.

Results
The NCR data yielded 8,239 patients with rare HBP tumors between 2016 and 2017. The ratios of rare tumors to all cancer types were 0.5%, 0.7%, 3.9%, 1.6%, 0.8%, and 7.2% in the liver, intrahepatic bile duct, gallbladder, extrahepatic bile duct, ampulla of Vater, and pancreas, respectively. Rare tumors occurred more frequently in men, except for gallbladder tumors. The main tumor stage was localized in liver cells (42.4%) and the intrahepatic bile duct (51.6%); more patients were diagnosed in advanced stage with gallbladder (84.1%) and extrahepatic bile duct (74.4%) tumors. Approximately equal percentage of patients were diagnosed at designated cancer care hospitals (DCCHs) and non-DCCHs, whereas 60% to 70% patients received treatment at DCCHs.

Conclusion
This is the first report to provide comprehensive information on the epidemiological status of rare HBP tumors in Japan by utilizing population-based NCR data.
Uptake of USPSTF recommendation to refer pregnant individuals for therapy or counseling to prevent perinatal depression
Authors: Felder Jennifer N. , Mirchandaney Riya , Dimidjian Sona 
Published: September 2022

Abstract

Purpose
Perinatal depression is the most common complication of pregnancy and childbirth, and it is associated with adverse consequences. The United States Preventive Services Task Force (USPSTF) recommends that pregnant and postpartum (i.e., perinatal) individuals at risk for depression be referred for therapy or counseling interventions; however, it is unclear to what extent this recommendation has been implemented.

Methods
Pregnant individuals were recruited via advertisements on a pregnancy app and a separate study on sleep. Respondents completed the initial screening questions to determine their risk for perinatal depression, defined as self-reported history of depression; recent stressors; history of emotional, sexual, or physical abuse; mild depressive symptoms; anxiety symptoms; single; diabetes diagnosis; or unwanted pregnancy. Eligible respondents reported their providers’ recommendations for preventing depression, and their utilization of interventions to prevent depression (n = 303).

Results
Fewer than 15% of participants reported that a provider referred them for therapy or counseling to prevent depression; recommendations included cognitive behavioral therapy (4%), interpersonal psychotherapy (2.3%), mindfulness-based cognitive therapy (4.3%), or other/unknown (6.6%). Approximately 12% reported that a provider recommended medication to prevent depression. Provider referral rates varied by risk factor, but not by patient demographics. Nearly 20% of participants reported using therapy or counseling to prevent depression, and nearly 13% reported using medication to prevent depression.

Conclusions
We explore potential factors affecting the uptake of the USPSTF recommendation and underscore the importance of preventing perinatal depression.
Artificial intelligence in medico-dental diagnostics of the face: a narrative review of opportunities and challenges
Authors: Patcas Raphael , Bornstein Michael M. , Schätzle Marc A. , Timofte Radu 
Published: September 2022

Abstract
Objectives
This review aims to share the current developments of artificial intelligence (AI) solutions in the field of medico-dental diagnostics of the face. The primary focus of this review is to present the applicability of artificial neural networks (ANN) to interpret medical images, together with the associated opportunities, obstacles, and ethico-legal concerns.

Material and methods
Narrative literature review.

Results
Narrative literature review.

Conclusion
Curated facial images are widely available and easily accessible and are as such particularly suitable big data for ANN training. New AI solutions have the potential to change contemporary dentistry by optimizing existing processes and enriching dental care with the introduction of new tools for assessment or treatment planning. The analyses of health-related big data may also contribute to revolutionize personalized medicine through the detection of previously unknown associations. In regard to facial images, advances in medico-dental AI-based diagnostics include software solutions for the detection and classification of pathologies, for rating attractiveness and for the prediction of age or gender. In order for an ANN to be suitable for medical diagnostics of the face, the arising challenges regarding computation and management of the software are discussed, with special emphasis on the use of non-medical big data for ANN training. The legal and ethical ramifications of feeding patients’ facial images to a neural network for diagnostic purposes are related to patient consent, data privacy, data security, liability, and intellectual property. Current ethico-legal regulation practices seem incapable of addressing all concerns and ensuring accountability.

Clinical significance
While this review confirms the many benefits derived from AI solutions used for the diagnosis of medical images, it highlights the evident lack of regulatory oversight, the urgent need to establish licensing protocols, and the imperative to investigate the moral quality of new norms set with the implementation of AI applications in medico-dental diagnostics.
Models of integrated care for young people experiencing medical emergencies related to mental illness: a realist systematic review
Authors: Otis Michaela , Barber Susan , Amet Mona , Nicholls Dasha 
Published: September 2022

AbstractMental illness heightens risk of medical emergencies, emergency hospitalisation, and readmissions. Innovations for integrated medical–psychiatric care within paediatric emergency settings may help adolescents with acute mental disorders to get well quicker and stay well enough to remain out of hospital. We assessed models of integrated acute care for adolescents experiencing medical emergencies related to mental illness (MHR). We conducted a systematic review by searching MEDLINE, PsychINFO, Embase, and Web of Science for quantitative studies within paediatric emergency medicine, internationally. We included populations aged 8–25 years. Our outcomes were length of hospital stay (LOS), emergency hospital admissions, and rehospitalisation. Limits were imposed on dates: 1990 to June 2021. We present a narrative synthesis. This study is registered on PROSPERO: 254,359. 1667 studies were screened, 22 met eligibility, comprising 39,346 patients. Emergency triage innovations reduced admissions between 4 and 16%, including multidisciplinary staffing and training for psychiatric assessment (F(3,42) = 4.6, P < 0.05, N = 682), and telepsychiatry consultations (aOR = 0.41, 95% CI 0.28–0.58; P < 0.001, N = 597). Psychological therapies delivered in emergency departments reduced admissions 8–40%, including psychoeducation (aOR = 0.35, 95% CI 0.17–0.71, P < 0.01, N = 212), risk-reduction counselling for suicide prevention (OR = 2.78, 95% CI 0.55–14.10, N = 348), and telephone follow-up (OR = 0.45, 95% CI 0.33–0.60, P < 0.001, N = 980). Innovations on acute wards reduced readmissions, including guided meal supervision for eating disorders (P = 0.27), therapeutic skills for anxiety disorders, and a dedicated psychiatric crisis unit (22.2 vs 8.5% (P = 0.008). Integrated pathway innovations reduced readmissions between 8 and 37% including family-based therapy (FBT) for eating disorders (X2(1,326) = 8.40, P = 0.004, N = 326), and risk-targeted telephone follow-up or outpatients for all mental disorders (29.5 vs. 5%, P = 0.03, N = 1316). Studies occurred in the USA, Canada, or Australia. Integrated care pathways to psychiatric consultations, psychological therapies, and multidisciplinary follow-up within emergency paediatric services prevented lengthy and repeat hospitalisation for MHR emergencies. Only six of 22 studies adjusted for illness severity and clinical history between before- and after-intervention cohorts and only one reported socio-demographic intervention effects.
p-Kähler and balanced structures on nilmanifolds with nilpotent complex structures
Authors: Sferruzza Tommaso , Tardini Nicoletta 
Published: September 2022

AbstractLet (X, J) be a nilmanifold with an invariant nilpotent complex structure. We study the existence of p-Kähler structures (which include Kähler and balanced metrics) on X. More precisely, we determine an optimal p such that there are no p-Kähler structures on X. Finally, we show that, contrarily to the Kähler case, on compact complex manifolds there is no relation between the existence of balanced metrics and the degeneracy step of the Frölicher spectral sequence. More precisely, on balanced manifolds the degeneracy step can be arbitrarily large.
The protective role of iodine and MS-222 against stress response and bacterial infections during Nile tilapia (Oreochromis niloticus) transportation
Authors: Sherif Ahmed H. , Eldessouki Elsayed A. , Sabry Nader M. , Ali Nadia G. 
Published: September 2022

Abstract
Fish transportation is a regular farming and experimental practice that mainly results in stress conditions that may extend to induce a high mortality rate. In the present experimental simulation, Oreochromis niloticus were transported for 2 h and maintained for another 6 h in transportation containers to assess the effect of tranquilization with tricaine methanesulfonate (MS-222) and/or the addition of iodine on mortality rate and restoring the normal physiological functions. Experimental fish were divided into four groups: group 1 (control) was transported in farm water without MS-222 or iodine, group (2) was transported in farm water supplemented with 40 mg/L of MS-222, fish in group (3) were transported in farm water supplemented with 40 mg/L of MS-222 + 10 ppm iodine, and fish in group (4) were transported in farm water containing 10 ppm iodine. Blood samples were collected for the determination of serum cortisol and glucose, while skin mucus was collected for assaying lysozyme, peroxidase and antibacterial activity; cumulative mortality rate; and food reflexes which were assessed at 0 h, 1 h, 6 h, 48 h, 7 days and 14 days post 2 h transportation. The results indicated that fish tranquilization with MS-222 and/or treatment with iodine mitigated the stress condition associated with transportation and accelerate restoration of the normal physiological and immunological status. So, it was recommended to use the MS-222 as a tranquillizer together with iodine as an antiseptic during transportation of O. niloticus.
Clinical significance of the neutrophil-to-lymphocyte ratio in oligometastatic breast cancer
Authors: Inoue Yuka , Fujishima Makoto , Ono Makiko , Masuda Jun , Ozaki Yukinori , Maeda Tetsuyo , Uehiro Natsue , Takahashi Yoko , Kobayashi Takayuki , Sakai Takehiko , Osako Tomo , Ueno Takayuki , Ohno Shinji 
Published: September 2022

Abstract
Purpose
This study investigated the clinical impact of pretreatment neutrophil-to-lymphocyte ratio (NLR) on survival in patients with oligometastatic breast cancer.

Patients and methods
We collected data from 397 patients who underwent primary breast surgery from 2004 to 2015 and developed recurrence during the follow-up. We reviewed the images and clinical information and defined OMD according to the European Society for Medical Oncology advanced breast cancer guidelines. The NLR was calculated using pretreatment data of primary breast cancer. The cutoff value of the NLR was determined by receiver operating characteristic curve with Youden Index.

Results
Among 397 patients, 131 had OMD at recurrence. The low-NLR group included patients of significantly older age at primary cancer than those in the high-NLR group. A low NLR indicated a better overall survival (p = 0.023) after adjusting for relevant factors, including estrogen receptor status, surgical resection of metastatic disease, metastatic organ number, disease-free interval, and liver metastasis than did the high-NLR group. We developed prognostic models for OMD using six independent prognostic factors, including the NLR. The number of factors was associated with overall survival; patients with all six favorable factors showed a good overall survival of 90.9% at 8 years and those with four or more factors showed 70.4%.

Conclusions
The NLR was an independent prognostic factor for overall survival in OMD. The number of favorable prognostic factors was associated with overall survival. A prognostic model, including the NLR, will help identify patients with a favorable prognosis.
Parent and Friend Relationship Quality and Links to Trajectories of Loneliness During the First Year of College
Authors: Calderon Leon Maria D. , Guassi Moreira João F. , Saragosa-Harris Natalie M. , Waizman Yael H. , Sedykin Anna , Peris Tara S. , Silvers Jennifer A. 
Published: September 2022

AbstractBeginning college involves changes that can increase one’s vulnerability to loneliness and associated negative outcomes. Parent and friend relationships are potential protective factors against loneliness given their positive association with adjustment. The present longitudinal study, with data collection at baseline, 1 month, and 2 months later, assessed the comparative effects of self-reported parent and friend relationship quality on loneliness in first-year college students (N = 101; 80 female, Mage = 18.36). At baseline, parent and friend relationship quality were negatively associated with loneliness. Longitudinal data revealed that friend relationship quality interacted with time, such that its effects on loneliness attenuated over the course of 2 months. By contrast, parent relationship quality continued to predict lower loneliness 2 months post-baseline. These results highlight the importance of close relationships and suggest that targeting relationship quality could be effective in helping youth transition to college.
TOUGH3-FLAC3D: a modeling approach for parallel computing of fluid flow and geomechanics
Authors: Rinaldi Antonio P. , Rutqvist Jonny , Luu Keurfon , Blanco-Martín Laura , Hu Mengsu , Sentís Manuel L. , Eberle Leandra , Kaestli Philipp 
Published: September 2022

AbstractThe recent development of the TOUGH3 code allows for a faster and more reliable fluid flow simulator. At the same time, new versions of FLAC3D are released periodically, allowing for new features and faster execution. In this paper, we present the first implementation of the coupling between TOUGH3 and FLAC3Dv6/7, maintaining parallel computing capabilities for the coupled fluid flow and geomechanical codes. We compare the newly developed version with analytical solutions and with the previous approach, and provide some performance analysis on different meshes and varying the number of running processors. Finally, we present two case studies related to fault reactivation during CO2 sequestration and nuclear waste disposal. The use of parallel computing allows for meshes with a larger number of elements, and hence more detailed understanding of thermo-hydro-mechanical processes occurring at depth.
Risky business: food fraud vulnerability assessments
Authors: Huisman Wim , van Ruth Saskia 
Published: September 2022

AbstractMajor food fraud scandals of the last decade have created awareness of the need to strengthen companies’ ability to combat fraud within their own organizations and across their supply chains. The scandals compelled food companies and the food industry as a whole to take action and to protect companies and industries against the threat of food fraud. Stakeholders expect food companies to act proactively to mitigate food fraud risks. Certification schemes expect food producers to consider food fraud and to undertake food fraud vulnerability assessments and prepare control plans to mitigate fraud risks. This paper examines how vulnerability for food fraud on company level and supply chain level can be assessed using criminological theory. First, the paper discusses how such theory can be applied for assessing motivations and opportunities for internal and external actors to commit food fraud and assessing existing control measures to mitigate these vulnerabilities. Second, the paper discusses the SSAFE-tool in which these elements have been used in a survey for assessing food fraud vulnerability of companies in food supply chains. Third, the paper evaluates the results of the application of the SSAFE-tool to several food supply chain and tiers, including milk, spices, extra olive oil, organic foods and the food service industry.
The relationship between natural rain intensity and Ascochyta blight in chickpea development
Authors: Khaliq Ihsanul , Moore Kevin , Sparks Adam H. 
Published: September 2022

AbstractAscochyta blight management strategy in chickpea standing crops in Australia is solely based on applying protective fungicides before a forecast rainfall event. Despite this, studies on the likely interaction between natural rain (as well as simulated rain) amount, duration and Ascochyta blight development are rare. This study was conducted to investigate the relationship between natural rain intensity (mm/h) and Ascochyta blight development. Infested chickpea residue were placed at the soil surface, and three pots of a susceptible chickpea cultivar were randomly placed on each side of the plot (total 12 pots and 36 plants), preceding a forecast rainfall event. Trap plants were transferred to a controlled temperature room after rain events. After a 48 h incubation period, trap plants were transferred to a glasshouse to allow lesion development. The number of lesions on all plant parts were counted after two weeks. Lesions developed in rain amounts as low as 1.4 mm and rain durations as short as 0.7 h. The number of lesions significantly increased with increasing rain amount. There was a positive effect of increasing rain duration and a negative effect of increasing wind speed. This study suggests that small rain amounts, shorter duration rains or a limited amount of primary inoculum are not barriers to conidial dispersal or host infection, and that the current value of a rainfallthreshold (2 mm) for conidial spread and host infection is not accurate for susceptible cultivars.
Bridge Principles and Epistemic Norms
Authors: Field Claire , Jacinto Bruno 
Published: September 2022

AbstractIs logic normative for belief? A standard approach to answering this question has been to investigate bridge principles relating claims of logical consequence to norms for belief. Although the question is naturally an epistemic one, bridge principles have typically been investigated in isolation from epistemic debates over the correct norms for belief. In this paper we tackle the question of whether logic is normative for belief by proposing a Kripkean model theory accounting for the interaction between logical, doxastic, epistemic and deontic notions and using this model theory to show which bridge principles are implied by epistemic norms that we have independent reason to accept, for example, the knowledge norm and the truth norm. We propose a preliminary theory of the interaction between logical, doxastic, epistemic and deontic notions that has among its commitments bridge principles expressing how logic is normative for belief. We also show how our framework suggests that logic is exceptionally normative.
Linguistic Interventions and the Ethics of Conceptual Disruption
Authors: Löhr Guido 
Published: September 2022

AbstractSeveral authors in psychology and philosophy have recently raised the following question: when is it permissible to intentionally change the meaning and use of our words and concepts? I argue that an arguably prior question has received much less attention: Even if there were good moral or epistemic reasons for conceptual or semantic changes, this does not yet justify pushing or lobbying for such changes if they are socially and conceptually disruptive. In this paper, I develop the beginnings of an ethics of conceptual disruption as well as a set of norms of linguistic interventions based on it.
Determinants of adherence to recommendations on physical activity, red and processed meat intake, and body weight among lynch syndrome patients
Authors: Hoedjes M , Vrieling A , de Brauwer L , Visser A , Gómez García E , Hoogerbrugge N , Kampman E 
Published: September 2022

AbstractThis study aimed to identify determinants of adherence to lifestyle and body weight recommendations for cancer prevention among Lynch Syndrome (LS) patients. Cross-sectional baseline data of LS patients participating in the Lifestyle & Lynch (LiLy) study was used to assess determinants of adherence to the World Cancer Research Fund cancer prevention recommendations on body weight, physical activity, and red and processed meat intake. Adherence and potential determinants of adherence were assessed using questionnaires. Multivariable logistic regression analyses were conducted to identify determinants of adherence. Of the 211 participants, 50.2% adhered to the body weight recommendation, 78.7% adhered to the physical activity recommendation, and 33.6% adhered to the red and processed meat recommendation. Being younger and having a higher level of education were associated with adherence to the recommendation on body weight. Having knowledge about the recommendation was associated with adherence to the recommendations on physical activity and red and processed meat. Results confirm that knowledge about recommendations for cancer prevention is an important determinant for adherence and suggest that strategies to increase knowledge should be included in lifestyle promotion targeted at LS patients, along with behavior change techniques influencing other modifiable determinants.