bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arquitectura y olvido : el Jockey Club de Goiás de Paulo Mendes da Rocha = Architecture and oblivion: the Jockey Club of Goiás by Paulo Mendes da Rocha
Authors: Mora Pereira Caixeta Eline Maria , Ramos Mahler Christine 
Published: February 2022

ResumenEste artículo presenta el estudio de una obra de Paulo Mendes da Rocha: el Jockey Club de Goiás, ubicado en el interior de Brasil. El objeto está poco explorado en las publicacio­nes, carece de una comprensión más profunda de sus valores materiales e inmateriales. El enfoque se centra en la trayectoria del edificio, contextualizando su diseño y construcción, con una mirada a la apropiación del espacio, desde el auge hasta la decadencia de este equipamiento urbano social y deportivo, con miras a su conservación y reinserción urbana. El objetivo es demostrar su importancia cultural, ya sea a través de la escala urbana, la ubicación estratégica, la calidad tectónica y el valor ambiental. Estos atributos justifican y posibilitan su reinserción en la ciudad del siglo XXI, con la absorción de nuevos usos rela­cionados a su vocación original. La discusión abre el camino para prácticas de conservación de edificios modernos en Brasil, más allá de la restauración. AbstractThis paper presents the case of one of Paulo Mendes da Rocha’s works: the Jockey Club of Goiás, located in the interior of Brazil. The object is little explored in publications, lacking a deeper understanding for its material and immaterial values. The approach focuses on the building’s trajectory, contextualizing its design and construction, with a look at the appro­priation of space, from the heyday to the decadence of this urban social and sporting equi­pment, with a view to its conservation and urban reintegration. The aim is to demonstrate its cultural significance, whether through urban scale strategic location, tectonic quality and environmental value. These attributes justify and enable its insertion in the 21s century city with the absorption of new uses related to its original vocation. The discussion opens the way for conservation practices of modern buildings in Brazil, beyond restoration.
Digital Entrepreneurship in the Last Decade: A Systematic Review
Authors: Amadi Chimezie , Zubairu Umaru Mustapha , Busra Sakariyan Olalekan , Imam Paiko Isah 
Published: February 2022

The objective of this paper is to investigate the effects ICT has on the sustainability of Digital Entrepreneurship in Nigeria. Furthermore, this paper seeks to determine if the utilization of ICT can forecast the rate of start-ups in the Digital Entrepreneurship sector and interrogate the characteristics and inter-relationships inherent in Digital Entrepreneurship. To achieve this objective, a systematic literature review using the Systematic Quantitative Assessment Technique (SQAT) was the methodology used to review 45 DE articles published over the last decade (2012 – 2021). To provide a thorough, impartial amalgam of the reviewed articles, this paper analysed the time distribution, geographic distribution, types and data collection methods of the 45 DE articles. The review revealed that existing research has been both empirical and conceptual in equal measure with only one instance in mixed mode. The parity suggests that future researchers should endeavour to conduct more conceptual research to underpin the envisaged accelerated growth of DE.
A single-institution study of so-called “non-secreting” intracranial germinomas: neurological characteristics, treatment procedures, and clinical outcomes
Authors: Zhou Jiajun , Lei Ting , Zuo Jinyi , Wu Chenxing , Liu Rui , Li Shouwei 
Published: February 2022

Abstract
Background and PurposeIntracranial germinomas are rare brain tumors. In the present study, we collected data of patients with histology-proven germinomas, and analyzed their neurological characteristics, treatment procedures, and clinical short-term outcomes.MethodsWe reviewed the data of patients with “non-secreting” intracranial germinomas from January 2012 to June 2021 in our institution from Beijing, China.ResultsThere were 162 (69.8%) male patients and 70 (30.2%) female patients. Pineal germinomas were mainly found in male patients (98.3%), and germinomas in sellar/suprasellar region were often observed in female patients (67.5%). The most common clinical presentations were polyuria/polydipsia (42.7%), headache (40.5%), visual disturbance (37.5%), and motor impairment (28.4%). The symptoms of endocrinological alteration had significantly longer duration before hospital admission. Patients with pure germinoma had a higher serum beta-human chorionic gonadotropin (β-HCG) level than the germinoma with syncytiotrophoblastic giant cells (STGCs) (P=0.001), and no significant difference was noted in serum alpha-fetoprotein (AFP) level between the two groups (P=0.540). Tumors with multiple lesions such as bifocal and multifocal diseases had a higher tendency to intracranial dissemination and spinal seeding at diagnosis (P<0.001 and P<0.001, respectively). The mean duration of open craniotomy was 268.8 min with an average volume of blood loss of 316.9 mL, compared with 27.0 min and 6.2 mL in cases who received stereotactic biopsy (P<0.001 and P<0.001). The most common complication in both groups was postoperative hemorrhage (7.0% and 8.5%). Patients who received biopsy had higher KPS scores at hospital discharge than on admission in contrast to open craniotomy (P=0.047). Deterioration of KPS at hospital discharge than on admission was observed in 29 and 1 cases who received craniotomy and biopsy (P<0.001).ConclusionsEndocrinological alteration has longer duration before diagnosis. Patients with multiple lesions such as bifocal and multifocal germinomas have a higher tendency of dissemination, and additional attention should be paid to the imaging findings. Patients may not necessarily benefit from the surgical resection because of the surgical trauma and the postoperative complications, and stereotactic biopsy is highly significant in clinical practice.
Numerical Investigation and Design of Optical on Chip Waveguide With Engineered Dispersion for Generation of Supercontinuum Based Frequency Combs
Authors: Alizadeh Mohammad Reza , Olyaee Saeed , Seifouri Mahmood 
Published: February 2022

Abstract
In this paper, with dispersion engineering, two waveguides with silicon core and SiO2 cladding are proposed to generation the supercontinuum spectrum and optical frequency combs. By injecting a pulse with a peak power of 800 (W) and a pulse duration of 50 (fs), the output supercontinuum spectrum is obtained from a wavelength of 1100 (nm) to 4000 (nm). Also, by applying a maximum power of 1 KW and a pulse width of 100 (fs), optical frequency combs based on a supercontinuum with a broadband frequency combs have been obtained. Our proposed structure has good potential for engineering and achieving flatness dispersion which there are two zero dispersion wavelengths at 1890 (nm) and 2850 (nm). This flat dispersion can be very useful to achieve the desired output spectrum. Due to the materials used and the flat structure of the proposed waveguides, these waveguides can be used for integrated optical circuits as well as applications in optical communications, spectroscopy, and sensors.
Applicability and Effectiveness of Ultrasound Combined Nerve Stimulator-Guided Lumbosacral Plexus Block in Supine Versus Lateral Position During Surgeries for Lower Limb Fracture-A Prospective Randomized Controlled Trial
Authors: Xu Yuting , Song Jie , Xia Xiaoqiong , Hu Xianwen , Li Yawen , Yu Yongbo , Wang Liang , Tao Zhiguo 
Published: February 2022

Abstract
Background:To compare the applicability and effectiveness of ultrasound combined nerve stimulator-guided lumbosacral plexus block (LSPB) in supine versus lateral position during the lower limb fracture surgery. Methods:Patients who underwent elective internal fixation for lower limb fracture were divided into the S group and the L group by the random number table method and received LSPB guided by ultrasound combined nerve stimulator in supine and lateral positions, respectively. The primary outcome examined was the dose of sufentanil used in surgery and the secondary outcomes were the maximum VAS pain score at position placing for LSPB, the time of position placing, the time for nerve block and the number of puncture attempts.Results:The maximum pain score at position placing, the time of position placing for nerve block, the time for lumbar plexus block and the time of puncture attempts were significantly lower in the S group compared with those of the L group (all P<0.05). However, the time for sacral plexus block was higher in the S group compared with that of the L group (P<0.05). The heart rate and mean arterial pressure at different time points, times of puncture attempts for sacral plexus, dose of sufentanil used, VAS scores, the satisfactory postoperative degree to analgesia and adverse events of nerve block did not significantly differ between the two groups (all P>0.05). Conclusions:LSPB in the supine position is simple to apply and has definite anesthetic effects. Meanwhile, it has a high comfort level and therefore should be widely applied. The trial was registered prior to patient enrollment at the Chinese Clinical Trail Registry (Date:11/03/2021 Number: ChiCTR2100044117).
Productivity, Global Value Chains and Cross-industry Spillovers in Turkey
Authors: dine Nasser Dine Nasser 
Published: February 2022

Abstract
This study examines the spillovers in productivity across industries and the impact of GVC participation, through backward and forward linkages, by estimating a spatial autoregressive model (SAR) using data drawn from the World Input-Output Dataset and Socio-Economic Accounts. We find that positive changes in productivity in one sector are significantly associated with higher productivity across sectors connected through input-output linkages. We find that productivity rises with forward linkages with a significant positive spillover across sectors through input-output connections, while backward linkages lead to declining productivity. A sectoral analysis shows that productivity benefits from forward linkages with positive spillover effects across service sectors but weakens with backward linkages within and across manufacturing sectors. This study empirically demonstrates that ignoring the spillovers effects in productivity leads to underestimating the impact of GVC participation on productivity.
Reliability Levels of Motor Competence In Youth Athletes
Authors: Silva Ana Filipa , Nobari Hadi , Badicu Georgian , Ceylan Halil Ibrahim , Lima Ricardo , Lagoa Maria João , Luz Carlos , Clemente Filipe Manuel 
Published: February 2022

Abstract
This study aimed to analyze the reliability of the tests included in the motor competence assessment (MCA) battery and compare the effects of the number of trials per test. Thirty female volleyball players (14.6±1.3 years of age) were tested. The participants performed two or three trials of each test. Intra-class correlation (ICC) was calculated, and a paired sample t-test analyzed the variations between trials (1st vs. 2nd vs. 3rd). Results revealed a significant difference between the first and the second trials for jumping sideways [t(29)=-4.108, p<0.01], standing long jump [t(29)=-3.643, p<0.01], and shuttle run [t(29)=-3.139, p<0.01]. No significant result was registered in the shifting platforms, ball throwing and kicking between the first and second trials. Hence, any difference was recorded between the second and third trial. High ICC values were registered among the three repetitions of shuttle run, ball throwing, and ball kicking, while almost perfect values were recorded for the standing long jump. Nevertheless, there seems to be a learning effect between the first and the second repetition—no differences were registered only considering the two manipulative tests. In conclusion, except for jumping sideways, the MCA tests are reliable and only need to be performed two times instead of three.
Learning Patient-Level Prediction Models Across Multiple Healthcare Databases: Evaluation of Ensembles for Increasing Model Transportability
Authors: Reps Jenna Marie , Williams Ross D. , Schuemie Martijn J. , Ryan Patrick B. , Rijnbeek Peter R. 
Published: February 2022

Abstract
Background: Prognostic models that are accurate could help aid medical decision making. Large observational databases often contain temporal medical data for large and diverse populations of patients. It may be possible to learn prognostic models using the large observational data. Often the performance of a prognostic model undesirably worsens when transported to a different database (or into a clinical setting). In this study we investigate different ensemble approaches that combine prognostic models independently developed using different databases (a simple distributed learning approach) to determine whether ensembles that combine models developed across databases can improve model transportability (perform better in new data than single database models)?Methods: For a given prediction question we independently trained five single database models each using a different observational healthcare database. We then developed and investigated numerous ensemble models (fusion, stacking and mixture of experts) that combined the different database models. Performance of each model was investigated via discrimination and calibration using a leave one dataset out technique, i.e., hold out one database to use for validation and use the remaining four datasets for model development. The internal validation of a model developed using the hold out database was calculated and presented as the ‘hypothetical optimum’ for comparison. Results: In this study the fusion ensembles generally outperformed the single database models when transported to a previously unseen database and the performances were more consistent across unseen databases. Stacking ensembles performed poorly in terms of discrimination when the labels in the unseen database were limited. Calibration was consistently poor when both ensembles and single database models were applied to previously unseen databases. Conclusion: A simple distributed learning approach that implements ensemble techniques to combine models independently developed across different databases for the same prediction question may improve the discriminative performance in new data (new database or clinical setting) but will need to be recalibrated using the new data. This could help medical decision making by improving prognostic model performance.
Quantum teleportation of an image
Authors: Qiu Xiaodong , Guo Haoxu , Chen Lixiang 
Published: February 2022

Abstract
Quantum teleportation lies at the heart of a variety of quantum technologies, most of which, however, focused on 2-dimensional qubit states only. A fundamental open challenge remains as to whether we can teleport multilevel qudit states with bipartite entanglement. Here, we demonstrate such a high-dimensional teleportation using photonic orbital angular momentum (OAM). We exploit “perfect vortices” for preparing high-dimensional yet maximal OAM entanglement and for performing faithful high-dimensional Bell sate measurements (HDBSM) based on sum-frequency generation. We experimentally achieve the average teleportation fidelity 0.8788±0.048 for a complete set of 3-dimensional mutually unbiased bases. More importantly, we succeed in realizing the first quantum teleportation of optical images, with the effective channel capacity κ > 100. Our scheme holds promise for future high-volume quantum image transmission.
Toxicological Evaluation of Biological and Electrochemical Treatments of Coal Mine-impacted Water (MIW) on Duckweed Landoltia Punctata
Authors: Rodrigues Caroline , Lalau Cristina M. , Núñez-Gómez Dámaris , Puerari Rodrigo C. , Follmann Hioná V. D. M. , Oscar Bianca V. , Lapolli Flávio R. , Matias William Gerson , Lobo-Recio María Ángeles 
Published: February 2022

Abstract

Two different coal mine-impacted water (MIW) treatments (biological via biostimulation of sulfate-reducing bacteria (SRB), and electrocoagulation (elC)) were proposed, reaching efficiencies of up to 99.79% in relation to SO42-, Fe, Mn, and Al ions, as well as acidity removals. Thus, toxicological assays with duckweed Landoltia punctata were performed, in order to verify the safeness and usability of the two treated waters. Therefore, duckweeds were exposed to different dilutions (0, 25, 50, 75, and 100% of samples) of the two treated waters, and the growth (r) and inhibition of growth (G) rates were calculated, based on 50% effect concentration (EC50). The water from the biological treatment (microcosm assay) presented the highest toxicity (EC50 = 33.42%), even higher when compared to the raw MIW (EC50 = 42.78%), probably due to the hydrogen sulfide, that even after a purge removal, remained in solution. The results showed that this water, despite being within the standards in physicochemical terms, demonstrated risks in terms of toxicity. The water from electrocoagulation (elC) treatment, in the opposite way, showed much less toxicity, even lower than the control, and therefore not reaching EC50, also suggesting a possible nutrient function of the treated water. Consequently, the treated water by elC could, for example, have a non-potable use. The study made it possible to prove the efficiency of elC treatment, the importance of post-treatment toxicological assessments, and the potential of the duckweeds as an option for a test organism in these types of evaluations.
Clinical Development of Anticancer Drugs Can Be enhanced Using Efficacy Data of Small Population Clinical Trials
Authors: Sawachi Keiichi , Matsumaru Naoki , Tsukamoto Katsura 
Published: February 2022

Abstract
Background

Although there are accelerated approval pathways based on the data of small populations and surrogate endpoints, the concern that these pathways authorize the use of inefficacious drugs based on limited data from earlier phase clinical trials remains. We retrospectively investigated the efficacy of anticancer drugs in small and large clinical trials and verified whether small clinical trials could reflect the efficacy results of large clinical trials.
Design:

All anticancer drugs approved in Japan or whose development was terminated from 2015 to 2019 were searched. The median overall survival (OS), median progression-free survival (PFS), and overall response rates (ORR) between small clinical trials (sample size ≤100) and large clinical trials (sample size >100) with identical target populations and treatment settings were compared. Simple linear regression and Spearman’s correlation analyses were performed.
Results

A total of 61 comparable small and large clinical trials were identified. For all endpoints, significant linear trend and correlation were detected (P < 0.001). In particular, the correlation coefficients of median OS and ORR were high (0.852 and 0.873, respectively).
Conclusion

The median OS, median PFS, and ORR data of small clinical trials precisely reflected the efficacy data of large clinical trials. Thus, the efficacy data of small clinical trials can be used to predict the efficacy data of a large population. These results support the accelerated approval pathway based on promising efficacy data of small populations in anticancer drug development.
Development and Verification of Ferroptosis-Related Gene Signature for Predicting the Prognosis and Immune Microenvironment in Gastric Cancer
Authors: Song Siyuan , Shu Peng 
Published: February 2022

Abstract
Objective:The study is to explore the role of ferroptosis-related genes (FRGs) in the occurrence and development of gastric cancer (GC), and to construct a new prognosis signature to predict the prognosis and immune microenvironment in GC.Method:We downloaded RNA sequencing data and related clinical information of GC from the Cancer Genome Atlas (TCGA-STAD) database as a training cohort. Microarray GSE84426 and GSE84437 were downloaded from Gene expression synthesis (GEO) database as validation cohorts. FRGs were come from FerDb. Prognostic genes associated with ferroptosis were identified in the training cohort using univariate Cox analysis and venn diagram, and two different molecular subtypes were identified by consistent clustering. Kaplan-Meier survival curve verified the prognostic value. ESTIMATE, CIBERSORT, McpCounter and TIMER algorithm were used to analyze the infiltration of immune cells in each sample. LASSO algorithm and multiple Cox regression analysis were used to construct a prognostic risk signature and verified it. Finally, gene set enrichment analysis (GSEA) revealed several important ways to participate in GC.Result: We obtained 16 prognostic genes for GC associated with ferroptosis, and divided GC patients into two subgroups by consistent clustering. Cluster C2 showed obvious median survival advantage, while Cluster C1 showed poor prognosis. Compared with Cluster C2, GC patients in Cluster C1 have significantly higher ESTIMATE score, higher immune cell infiltration and higher matrix score. MCPCounter, TIMER and CIBERSORT algorithms also showed that Cluster C1 had more immune cell infiltration, suggesting that the tumor immune microenvironment (TIME) of GC patients in high-risk group Cluster C1 accorded with immune exclusion subtype. Based on LASSO analysis, a risk signature was established, and it was found that TUBE1, NFE2L2 and ACSL4 genes were protective factors, while ZFP36, NOX5 and MIR9-3 genes were risk factors. Through the verification of GEO cohort, the risk signature of FRGs had a great potential to predict the prognosis of GC patients, and it was a strong correlation between the prognosis signature and GC immunity. The nomogram combined with risk signature and clinical features can accurately predict the prognosis of GC patients. GSEA analysis showed that compared with Cluster C2, Cluster C1 had lower expression in lipid metabolism and glutathione metabolism, which may be related to poor prognosis of GC patients. Conclusion: We constructed a new prognostic signature based on ferroptosis-related prognostic genes to predict the prognosis and TIME in GC, and the development of this signature had provided a new clue for determining the relationship between ferroptosis and immunity, which can be used to accurately predict the prognosis of GC patients and provide new strategies for immunotherapy of GC patients.