bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post‐procedural bleeding rate and haemostatic treatment use for dental procedures before and after the implementation of a standardized protocol for people with inherited bleeding disorders
Authors: Champagne Pier‐Ann , Bourassa Michelle , Desjardins Marie‐Pier , Cloutier Stéphanie , Demers Christine , Singbo Narcisse Ulrich , Néron Hélène , Pelland‐Marcotte Marie‐Claude 
Published: June 2022

AbstractIntroductionPersons with inherited bleeding disorders are at a substantial risk of bleeding following dental procedures.AimTo compare the outcomes and use of haemostatic treatment pre‐ and post‐implementation of a standardized protocol for dental procedures at a Hemophilia Treatment Centre.MethodsWe conducted a retrospective cohort study of outpatient and inpatient dental procedures and maxillofacial surgeries sustained by people with bleeding disorders treated at a comprehensive Hemophilia Treatment Centre (2013‐2020), comparing patients’ outcomes before and after the introduction of the protocol in 2018. The protocol, built using a multidisciplinary approach, suggested haemostatic treatment based on the invasiveness of the dental procedure and the proposed anaesthesia. Our primary outcome was the rate of procedural bleeding leading to medical or dental reintervention within 10 days. Secondary outcomes included the use of systemic haemostatic treatment and treatment‐related adverse effects.ResultsOverall, 137 dental procedures in 95 patients (median age: 29 years; 78% males; 74% haemophilia, 14% von Willebrand disease, 12% other disorders) were included.Seventeen procedural bleedings were reported (12.4%). Procedural bleeding occurred in 14.8% and 8.9% of patients in the control and intervention groups (p = .304). No major bleeding occurred. Tranexamic acid was used more consistently after protocol implementation (72.8% vs. 89.3%, p = .019), while factor concentrates use decreased (65.4% vs. 44.6%, p = .016), and desmopressin use remained constant (46.4% vs. 32.1%, p = .100). No treatment‐related adverse effects were reported.ConclusionThe use of a standardized protocol increased the use of tranexamic acid, with a nonstatistically significant reduction in procedural bleeding rate.
Including the voice of paediatric patients: Cocreation of an engagement game
Authors: Teela Lorynn , Verhagen Lieke E. , Gruppen Mariken P. , Santana Maria J. , Grootenhuis Martha A. , Haverman Lotte 
Published: June 2022

AbstractBackgroundEngaging patients in health care, research and policy is essential to improving patient‐important health outcomes and the quality of care. Although the importance of patient engagement is increasingly acknowledged, clinicians and researchers still find it difficult to engage patients, especially paediatric patients. To facilitate the engagement of children and adolescents in health care, the aim of this project is to develop an engagement game.MethodsA user‐centred design was used to develop a patient engagement game in three steps: (1) identification of important themes for adolescents regarding their illness, treatment and hospital care, (2) evaluation of the draft version of the game and (3) testing usability in clinical practice. Adolescents (12–18 years) were engaged in all steps of the development process through focus groups, interviews or a workshop. These were audio‐recorded, transcribed verbatim and analysed in MAXQDA.Results(1) The important themes for adolescents (N = 15) were included: visiting the hospital, participating, disease and treatment, social environment, feelings, dealing with staff, acceptation, autonomy, disclosure and chronically ill peers. (2) Then, based on these themes, the engagement game was developed and the draft version was evaluated by 13 adolescents. Based on their feedback, changes were made to the game (e.g., adjusting the images and changing the game rules). (3) Regarding usability, the pilot version was evaluated positively. The game helped adolescents to give their opinion. Based on the feedback of adolescents, some last adjustments (e.g., changing colours and adding a game board) were made, which led to the final version of the game, All Voices Count.ConclusionsWorking together with adolescents, All Voices Count, a patient engagement game was developed. This game provides clinicians with a tool that supports shared decision‐making to address adolescents' wishes and needs.Patient or Public ContributionPaediatric patients, clinicians, researchers, youth panel of Fonds NutsOhra and patient associations (Patient Alliance for Rare and Genetic Diseases, Dutch Childhood Cancer Organization) were involved in all phases of the development of the patient engagement game—from writing the project plan to the final version of the game.
Wear behavior of (Mo–Nb–Ta–V–W)C high‐entropy carbide
Authors: Medved' Dávid , Ivor Michal , Kovalčíková Alexandra , Múdra Erika , Csanádi Tamás , Sedlák Richard , Ünsal Hakan , Tatarko Peter , Tatarková Monika , Šajgalík Pavol , Dusza Ján 
Published: June 2022

AbstractWear characteristics of an (Mo–Nb–Ta–V–W)C high‐entropy carbide were investigated using ball‐on‐flat technique. The experimental material with a high relative density of 99.0%, single phase, average grain diameter of 10.7 μm, and nanohardness of grains 28.6 GPa was prepared by ball‐milling and two‐step field‐assisted sintering. The tribological test was realized during dry sliding in air with the SiC ball as tribological partner at applied loads 5, 25, and 50 N. The microstructure, deformation, and damage characteristics were studied using scanning electron microscopy and confocal electron microscopy. The friction coefficient values during the test with 5 and 25 N were very similar and stable, with a value of approximately .4, whereas during the test with 50 N, it decreased from the value of .48–.42. The specific wear rate increased with increasing load from 3.71 × 10–7 mm3/N m at 5 N to 2.59 × 10–6 mm3/N m at 50 N. The dominant wear mechanism was mechanical wear with intensive grains pullout, fracture, and powder formation, without visible tribochemical reactions and tribo‐layer formation. The wear rate decreased due to the created rolling contacts among the tribopartners thanks to the hard and spherical nanopowders present.
Slurry erosion behavior of thermally sprayed ceramic nanocomposite coatings on turbine steel
Authors: Kumar Rajinder , Goyal Khushdeep , Bhandari Deepak 
Published: June 2022

AbstractThe aim of the present study is to investigate the slurry erosion behavior of nano‐yttria‐stabilized zirconia (YSZ) reinforced Cr3C2–25NiCr ceramic nanocomposite coatings deposited on turbine steel. The Cr3C2–25NiCr coating powder, 95% (Cr3C2–25NiCr) + 5% YSZ, and 90% (Cr3C2–25NiCr) + 10% YSZ nanocomposite coating powder deposited on CA6NM steel samples by using high‐velocity oxy‐fuel coating technique. L9orthogonal array Taguchi method was used to design the experiment. Erosion tests were performed on erosion test rig under hydro accelerated conditions at different levels of various parameters. Erosion tests and analysis of variance resulted that for coated samples, velocity is the major influencing factor followed by slurry concentration, impact angle, and particle size. Velocity was the largest contributor to the mass loss, whereas particle size has the least contribution to mass loss of the coated samples. The scanning electron microscopy analysis of eroded samples revealed that craters, micropores, platelets, plowing, spalling, and so on were responsible for the mass loss of uncoated and coated samples. The incorporation of YSZ nanoparticles decreased the porosity; erodent particles cannot penetrate more deeply inside the workpiece and resulted in less erosion. It has been resulted that 95% (Cr3C2–25NiCr) + 5% YSZ and 90% (Cr3C2–25NiCr) + 10% YSZ ceramic nanocomposite coatings exhibited better erosion resistance as compared to Cr3C2–25NiCr coatings due to high microhardness and low porosity.
Disaster selfies: How ethical reminders can mitigate morally questionable consumption practices
Authors: Akin Tugce , von Schuckmann Julia 
Published: June 2022

AbstractJoyful selfies taken at disaster sites create a controversial topic in terms of moral boundaries in digital life. While some consider it acceptable to take smiley selfies in a tragedy zone, others find this behaviour morally questionable. This article demonstrates empirically that excessive time spent on social media explains, at least partially, a greater tendency to like morally ambiguous content on social media. Specifically, this article shows that consumers tend to like more questionable content (such as smiley disaster selfies) on social media when they spend more time online. Further, this article shows that this effect is mediated by increased individualistic thinking. Responses to the survey experiment (N = 206) compared the tendency to like morally ambiguous content between groups of little, moderate and excessive use of social media, and tested for the mediating role of individualistic thinking on the relationship between time spent and liking behaviour. Second, the moderating role of an ethical reminder on time spent and the fact of liking morally ambiguous contents is demonstrated. In the presence of an ethical reminder, the effect of time spent on social media and liking morally ambiguous content becomes insignificant. This article contributes to theory on social media consumption by offering a novel underlying mechanism, such as increased individualistic thinking, as one variable that partly explains the liking for morally ambiguous content. This article also offers practical contributions for social media platforms and policy makers, showing that ethical reminders could be a possible and simple nudge to help consumers act more morally or become aware of morally questionable content.
Child ADHD and autistic traits, eating behaviours and weight: A population‐based study
Authors: Harris Holly A. , Bowling April , Santos Susana , Greaves‐Lord Kirstin , Jansen Pauline W. 
Published: June 2022

SummaryBackgroundChildren with Autism Spectrum Disorder (ASD) and Attention‐Deficit/Hyperactivity Disorder (ADHD) have an increased obesity risk. Although these conditions commonly co‐occur, shared factors relating to obesity risk are unknown.ObjectivesTo examine the shared and unique associations of ADHD and autistic traits with eating behaviours and BMI.MethodsChildren (N = 4134) from the population‐based Generation R Study were categorized into subgroups based on parent‐reported ADHD and autistic traits scores at 6 years: ADHDHigh, ASDHigh, ADHD+ASDHigh and REF (reference group: ADHD+ASDLow). Multiple linear regressions examined the associations between subgroups and eating behaviours (at 10 years) and BMIz (at 14 years), relative to REF. Mediation analyses tested the indirect effect of subgroup and BMIz through eating behaviours.ResultsADHD + ASDHigh children expressed both food approach (increased food responsiveness and emotional overeating) and avoidant eating behaviours (increased emotional undereating, satiety responsiveness/ slowness in eating and picky eating, and decreased enjoyment in food). ASDHigh children were more food avoidant, while ADHDHigh children had more food approach behaviours and greater BMIz. ADHDHigh and BMIz were indirectly associated with food responsiveness and emotional overeating.ConclusionsADHD and autistic trait phenotypes show distinct associations with potential obesity risk factors, and further research is needed to improve targeted early intervention.
How to deal with negative online employer reviews: An application of image repair theory
Authors: Kollitz Rouven , Ruhle Sascha , Wilhelmy Annika 
Published: June 2022

AbstractAlthough negative employer reviews pose a threat to employers by reducing organizational attractiveness, employers can respond to reviews to avert these threats. However, we lack a clear understanding of the response strategies and factors that determine response strategies' impact. To address this issue, we introduce image repair theory (IRT) as a promising theoretical foundation in the study of employer response. Using an experimental design, we tested the effects of IRT's general image repair strategies (i.e., Denial, Evasion of Responsibility, Reducing Offensiveness, Corrective Action, and Mortification) and the mechanisms underlying these effects according to IRT. Moreover, we explored the role of review content (i.e., the type of employer image information the review entails) as a contingency factor. We found differences between Denial, Corrective Action, and Mortification, which show that the choice of response strategies can matter and that the relationship between response strategy and potential applicants' perceptions of organizational attractiveness is mediated by attributions of responsibility rather than by perceived offensiveness. In addition, our results suggest that when negative reviews contain information about instrumental rather than symbolic employer image attributes, potential applicants can attribute more responsibility to the employer. Furthermore, only the effects of Reducing Offensiveness and Mortification were dependent on the review's content. We discuss theoretical implications and practical recommendations for employers that respond to negative employer reviews.
Mineralocorticoid receptor deficiency in Treg cells ameliorates DSS‐induced colitis in a gut microbiota‐dependent manner
Authors: Liu Ting , Li Yu‐Lin , Zhou Lu‐Jun , Sun Xue‐Nan , Wang Yong‐Li , Du Lin‐Juan , Liu Yuan , Zhu Hong , Chen Bo‐Yan , Sun Jian‐Yong , Liu Yan , Xu Shuo , Ye Hui‐Lin , Huang Shi‐Jia , Wang Xiaoxia , Li Bin , Duan Sheng‐Zhong 
Published: June 2022

AbstractMineralocorticoid receptor (MR) is a classic nuclear receptor and an effective drug target in the cardiovascular system. The function of MR in immune cells such as macrophages and T cells has been increasingly appreciated. The aim of this study was to investigate the function of Treg MR in the process of inflammatory bowel disease (IBD). We treated Treg MR‐deficient (MRflox/floxFoxp3YFP‐Cre, KO) mice and control (Foxp3YFP‐Cre, WT) mice with dextran sodium sulphate (DSS) to induce colitis and found that the severity of DSS‐induced colitis was markedly alleviated in Treg MR‐deficient mice, accompanied by reduced production of inflammatory cytokines, and relieved infiltration of monocytes, neutrophils and interferon γ+ T cells in colon lamina propria. Faecal microbiota of mice with colitis was analysed by 16S rRNA gene sequencing and the composition of gut microbiota was vastly changed in Treg MR‐deficient mice. Furthermore, depletion of gut microbiota by antibiotics abolished the protective effects of Treg MR deficiency and resulted in similar severity of DSS‐induced colitis in WT and KO mice. Faecal microbiota transplantation from KO mice attenuated DSS‐induced colitis characterized by alleviated inflammatory infiltration compared to that from WT mice. Hence, our study demonstrates that Treg MR deficiency protects against DSS‐induced colitis by attenuation of colonic inflammatory infiltration. Gut microbiota is both sufficient and necessary for Treg MR deficiency to exert the beneficial effects.
Antibody‐dependent cell‐mediated cytotoxicity using T cells with NK‐like phenotype in combination with avelumab, an anti‐PD‐L1 antibody
Authors: Liu Dong , Hu Yuefeng , Wei Jian , Zhang Wen , Piao Chunmei , Lu Yongcheng , Wang Yue , Liu Jingwei , Lu Xu 
Published: June 2022

AbstractThough the PD‐L1 checkpoint inhibitor avelumab has shown efficacy in the treatment of some types of cancer, improved treatment strategies are desperately needed. We evaluated whether combined treatment with avelumab and adoptively transferred T‐NK cells can provide enhanced anti‐cancer effects for treating PD‐L1‐expressing tumours. Our results demonstrate that avelumab specifically targets tumour cells with high PD‐L1 expression, and that cytolytic effects are mediated by T‐NK effector cells cultured from patient peripheral blood monocytic cell populations. The effects were dependent on CD16 and the perforin/granzyme pathway, supporting a role for the T‐NK subpopulation. In vivo assays verified the efficacy of T‐NK cells in combination with avelumab in reducing tumour growth. Furthermore, T‐NK + avelumab prolonged survival in a mouse orthotopic xenograft model. Collectively, our findings provide a basis for the combined use of adoptively transferred T‐NK cells with avelumab as a novel strategy for cancer treatment.
Multi‐responsive mesoporous polydopamine composite nanorods cooperate with nano‐enzyme and photosensitiser for intensive immunotherapy of bladder cancer
Authors: Wu Xiang , Wei Yongbao , Lin Rongcheng , Chen Pingzhou , Hong Zhiwei , Zeng Rong , Xu Qingjiang , Li Tao 
Published: June 2022

AbstractBladder cancer is a common malignancy in the urinary system. Defects of drug molecules in bladder during treatment, such as passive diffusion, rapid clearance of periodic urination, poor adhesion and permeation abilities, lead to low delivery efficiency of conventional drugs and high recurrence rate of disease. In this study, we designed multi‐responsive mesoporous polydopamine (PDA) composite nanorods cooperating with nano‐enzyme and photosensitiser for intensive immunotherapy of bladder cancer. The strongly adhesive mesoporous PDA with wheat germ agglutinin on nanoparticles could specifically adhere to epithelial glycocalyx and made the nanoparticles aggregate in urinary pathways. Meanwhile, 2,3‐dimethylmaleic anhydride could be hydrolysed in acidic conditions of tumour microenvironment, giving it a positive charge (charge reversal), which is more amenable to enter cancer cells. Afterwards, manganese dioxide nanorods could catalyse the reaction of excess H2O2 in tumour microenvironment to generate active oxygen, so as to change the hypoxic environment in tumour, and achieve a pH‐responsive for slow release of PD‐L1. After the ICG was irradiated by infrared light, a large amount of singlet oxygen was generated, thereby enhancing the therapeutic effect and reducing toxicity in vivo. Besides, mesoporous PDA with indocyanine green photothermal agent could have a local heat up quickly under the near‐infrared light to kill cancer cells, thereby enhancing therapeutic efficacy. Accordingly, this mesoporous PDA composite nanorods shed a light on bladder tumour treatment.
Comparison of the immunogenicity of five COVID‐19 vaccines in Sri Lanka
Authors: Jeewandara Chandima , Aberathna Inoka Sepali , Danasekara Saubhagya , Gomes Laksiri , Fernando Suranga , Guruge Dinuka , Ranasinghe Thushali , Gunasekera Banuri , Kamaladasa Achala , Kuruppu Heshan , Somathilake Gayasha , Jayamali Jeewantha , Jayathilaka Deshni , Wijayatilake Helanka Dinesh Kumara , Pushpakumara Pradeep Darshana , Harvie Michael , Nimasha Thashmi , de Silva Shiromi Devika Grace , Wijayamuni Ruwan , Schimanski Lisa , Rijal Pramila , Tan Jack , Townsend Alain , Ogg Graham S. , Malavige Gathsaurie Neelika 
Published: June 2022

AbstractTo determine the antibody responses elicited by different vaccines against SARS‐CoV‐2, we compared antibody responses in individuals 3 months post‐vaccination in those who had received different vaccines in Sri Lanka. Abs to the receptor binding domain (RBD) of the ancestral (wild type) virus (WT) as well as to variants of concern (VoCs), and ACE2 blocking Abs, were assessed in individuals vaccinated with Moderna (n = 225), Sputnik V (n = 128) or Sputnik light (n = 184) and the results were compared with previously reported data on Sinopharm and AZD1222 vaccinees. A total of 99.5% of Moderna, >94% of AZD1222 or Sputnik V and >70% of Sputnik light, >60% of Sinopharm vaccine recipients, had a positive response to ACE2 blocking antibodies. The ACE2 blocking antibody levels were highest to lowest was Moderna > Sputnik V/AZD1222 (had equal levels) > Sputnik light > Sinopharm. All Moderna recipients had antibodies to the RBD of WT, alpha and beta, while positivity rates for delta variant was 80%. The positivity rates for Sputnik V vaccinees for the WT and VoCs were higher than for AZD1222 vaccinees while those who received Sinopharm had the lowest positivity rates (<16.7%). The total antibodies to the RBD were highest for the Sputnik V and AZD1222 vaccinees. The Moderna vaccine elicited the highest ACE2 blocking antibody levels followed by Sputnik V/AZD1222, while those who received Sinopharm had the lowest levels. These findings highlight the need for further studies to understand the effects on clinical outcomes.
International Nurses Day: Nurses can change the world, given the investment and support they deserve
Authors: Catton Howard 
Published: June 2022

AbstractEvery year on International Nurses Day (IND), the International Council of Nurses (ICN) releases a report with resources that can be used by nurses around the world. This year's report responds to the World Health Organization's (WHO) latest strategy for nursing and midwifery, and the findings of the State of the World's Nursing report. In this article, ICN Chief Executive Officer Howard Catton describes the main points of the IND report and recommends that nurses everywhere read it, alongside the WHO strategy, and use that information to increase their knowledge of the global nursing workforce and influence global healthcare policy. It is a toolkit that can assist nurses, other healthcare providers, governments and international organisations to turn global strategy into meaningful local action and improved clinical practice on the ground.
Nurses' experiences of workplace violence in the emergency department
Authors: Al‐Natour Ahlam , Abuziad Lubna , Hweidi Lama Issa 
Published: June 2022

AbstractThe aimTo describe nurses’ perceptions about predisposing factors, nurses’ roles and effective strategies to combat workplace violence (WPV) in the emergency department (ED).BackgroundVarious forms of WPV against nurses is highly prevelent in EDs in Jordan and elsewhere. There is a dearth of information about predisposing factors for WPV and what strategies nurses use to counter this.MethodA qualitative descriptive design was used to describe nurses’ perceptions about their roles and effective strategies regarding WPV. A purposive sample of 24 nurses (12 male and 12 female) who were working in the ED at two Jordanian hospitals participated in this study. Semi‐structured interviews were conducted for each participant. The data were analysed using Colaizzi's narrative analysis steps and the Lincoln and Guba's framework to ensure credibility and trustworthiness.ResultsThree major themes emerged from the analysis of the data: (1) predisposing factors for WPV in ED, (2) the roles adopted by nurses in WPV incidents and (3) beneficial strategies to counter WPV.ConclusionParticipant nurses provided insights into the predisposing factors of WPV in Jordanian EDs. A range of strategies and roles used by nurses to counter WPV in health institutions and community contexts were identified. However, the effective strategies used by nurses confronted by WPV did not emerge from having been trained or educated for such crises and therefore WPV remains underestimated and underreported.Implication for nursing policymakersViolence of all types is a crime and laws need to be not only strong but also appropriately enforced. Employers have a legal responsibility to provide a safe workplace for staff. Their organizational policies about workplace safety must reflect national laws as well as the human rights of people who come to work in their organizations. Workplace policies need to emphasise safety measures, professional training and education for assuring a safe hospital environment. It is crucial to conduct culturally competent programmes for preventing and countering WPV, taking into consideration the nurses’ Jordanian cultural backgrounds and context.