bluuebunny/crossref_metadata_2025_split huggingface dataset:
The FAST VAN for Field Identification of Large Vessel Occlusion in Acute Stroke
Authors: Wasyliw Sanchea , Whelan Ruth , Davy Kim , Kelly Michael E. , Graham Brett , Gould Layla , Hunter Gary 
Published: May 2022

ABSTRACT:Background:There is definitive evidence for effectiveness of thrombectomy for acute stroke with large vessel occlusion (LVO). A clinical tool to identify patients with LVO is therefore required for effective triage and prehospital decision making. We developed the FAST VAN tool, which follows from the Heart and Stroke Foundation FAST stroke screen, with the addition of cortical features of vision, aphasia, and neglect, to differentiate from lacunar syndromes.Methods:Consecutive acute stroke alerts initiated by emergency medical services (EMS) were prospectively analyzed from April 2017 to Jan 2021. FAST VAN signs were recorded by first responders who had received online education about the tool. These findings were compared to the presence or absence of LVO on CT angiography. Analysis was also performed by appropriateness for comprehensive stroke centers (CSC) transfer if no LVO was present. EMS providers were surveyed regarding ease of use in terms of learning the tool and using in real-world practice.Results:Data from 1080 consecutive acute strokes included 440 patients considered to have VAN signs by EMS. Fifty-four percent of VAN-positive patients showed LVO on CTA. Sensitivity, specificity, and accuracy were 86%, 75%, and 77%, respectively. In 204 false-positive cases, 143 (70%) were considered appropriate for evaluation at the CSC. EMS providers reported high satisfaction with learning and using the tool.Discussion:The FAST VAN tool for identification of LVO meets desired characteristics of an effective screening tool in ease of use, efficiency, and accuracy. Aphasia remains the most challenging cortical feature to identify accurately.
Economic losses in dairy farms due to heat stress in sub-tropics: evidence from North Indian Plains
Authors: Choudhary Bishwa Bhaskar , Sirohi Smita 
Published: May 2022

AbstractThe present study assesses the sensitivity of dairy animals to thermal stress, and projects the economic losses due to heat stress in the Trans and Upper Gangetic plains region of India with Representative Concentration Pathway (RCP) 4.5 climate scenario for the time slice 2010–2039 and two subperiods, 2020–2029 and 2030–2039. The projections were carried out for two different scenarios of population and productivity growth of dairy animals, Business-as-Usual (BAU) and Alternate, whereby land, feed and fodder constraints were applied. The potential annual loss in milk production due to heat stress in the region was estimated to be around 361 and 377 thousand tons for the time slice 2010–2039 under BAU and Alternate scenario, respectively. In economic terms these losses, at current prices, would be equivalent to INR 11.93 billion and INR 12.44 billion, respectively. This gives an indication of the level of financial investment that can be made in adaptation measures to arrest the loss due to climate change.
Probability of clinically significant hearing recovery following salvage intratympanic steroids for sudden sensorineural hearing loss in the ‘real world’
Authors: Li L Q , Bennett A M D 
Published: May 2022

AbstractObjectiveThis study aimed to determine the probability of hearing recovery in patients with idiopathic sudden sensorineural hearing loss following salvage intratympanic steroidsMethodA retrospective review of all patients receiving salvage intratympanic steroid injections for idiopathic sudden sensorineural hearing loss was performed (January 2014 to December 2019). Twenty-two patients were identified, of whom 15 met inclusion criteria. Pre- and post-treatment audiograms were compared with the unaffected ear. Hearing recovery was categorised based on American Academy of Otolaryngology Head and Neck Surgery criteria.ResultsOnly 1 patient out of 15 (6.7 per cent) made a partial recovery, and the remainder were non-responders. The median duration of time between symptom onset and first salvage intratympanic steroid treatment was 52 days (range, 14–81 days). No adverse reactions were observed.Conclusion‘Real world’ patients with idiopathic sudden sensorineural hearing loss present differently to those in the literature. Sudden sensorineural hearing loss should be diagnosed with care and intratympanic steroid injections initiated early if considered appropriate. Patients should make an informed decision on treatment based on prognostic factors and local success rates.
Blockchain’s potential in forest offsets, the voluntary carbon markets and REDD+
Authors: Kotsialou Grammateia , Kuralbayeva Karlygash , Laing Timothy 
Published: May 2022

SummaryIncreasing net-zero commitments by individuals, companies and governments have been accompanied by the growth of the voluntary offset market, including Reducing Emissions from Deforestation and Forest Degradation (REDD+). Technologies, notably blockchain, are starting to enter the REDD+ space and may have the potential to address issues such as additionality, permanence, leakage and property and community rights. In this Perspective, we first examine voluntary markets and the role forest carbon offsets have played within them, highlighting the evolution of REDD+ and the issues that have hindered its development. We then examine the potential of blockchain to address each of the issues, using the literature and emerging experience from the use of blockchain in the forestry space. We find that the technology may have the potential to improve verifiability, reduce transaction costs and, to a lesser degree, aid in addressing additionality and permanence concerns. However, greater learning from the emerging use of blockchain in pilot projects is needed to fully assess and maximize its potential.
Prognostic utility of echocardiographically derived left ventricular strain in assessing neonatal enteroviral myocarditis outcome
Authors: Bigg Hugh F. , Kindel Steven J. , Kuhn Evelyn , Frommelt Peter C. 
Published: May 2022

AbstractBackground:Neonatal enteroviral myocarditis is a rare but potentially fatal illness. We sought to identify echocardiographic markers at diagnosis that could help risk-stratify infants for poor outcome and to characterise late sequelae.Methods:We reviewed data for infants <30 days of age diagnosed with enteroviral myocarditis between 1999 and 2019 at Children’s Wisconsin. Echo measures were collected retrospectively from the initial neonatal study including left ventricular ejection fraction, shortening fraction, diastolic and systolic dimensions, and peak global circumferential and longitudinal strain.Results:Fourteen neonates were diagnosed at an average age of 11 days. All had abnormal left ventricular ejection fraction (mean 38%; range 22–53%) at diagnosis. Three infants died, and one required transplantation during initial hospital. The 10 transplant-free survivors had significantly better global circumferential strain and global longitudinal strain at the initial echo compared to the 4 who died or needed transplant (global circumferential strain −13.2% versus −6.8%, p = 0.005; global longitudinal strain −8.8% versus −4.7%, p = 0.016). All other measures of left ventricular systolic function/dimensions were similar between the two groups. Follow-up data were available for 8/10 survivors; 5/8 had a persistently abnormal echo at an average interval of 8.3 years. 4/8 developed a left ventricular aneurysm that was consistently localised to the posterior basal wall.Conclusions:Neonatal enteroviral myocarditis carries a high risk of early mortality and late morbidity. Echo-derived left ventricular strain measures have utility in risk stratifying infants with enteroviral myocarditis. Most survivors continue to have late dysfunction necessitating cardiology surveillance and medical therapy.
‘I Knew I Should Stop, but I Couldn’t Control Myself’: a qualitative study to explore the factors influencing adolescents’ consumption of sugar-sweetened beverages and sugary snacks from a socio-ecological perspective
Authors: Wang Chia-Wen , Chen Duan-Rung , Chan Chang-Chuan , Yeh Yen-Po , Chen Hsiu-Hsi 
Published: May 2022

AbstractObjective:To explore the factors influencing Taiwanese adolescents’ consumption of sugar-sweetened beverages (SSB) and sugary snacks from a socio-ecological perspective.Design:This study adopted a qualitative design by using face-to-face, in-depth interviews guided by a semistructured questionnaire.Setting:Eight junior high schools in New Taipei City and Changhua County, Taiwan, September to November 2018.Participants:Fifty-nine participants aged 12–14 years participated in this study.Results:Reflexive thematic analysis was used to analyse the data. This study identified four themes to address the multifaceted factors that influence adolescents’ consumption of SSB and sugary snacks. At the intrapersonal level, physiological factors, psychological factors, individual economic factors and taste preferences were mentioned in connection with people’s consumption of SSB and sugary snacks. Positive or negative influences of parents, siblings, peers and teachers on SSB and sugary snack intake were identified at the interpersonal level. The availability of SSB and sugary snacks at home, their availability in vending machines or in school stores in the school environment and participants’ access to convenience stores and hand-shaken drink shops in the broader community influenced SSB and sugary snack consumption. Additionally, food culture and food advertising were identified as influencing societal factors.Conclusions:Overall, this qualitative study determined not only that the consumption of SSB and sugary snacks is influenced by intrapersonal factors but also that interpersonal, environmental and societal factors affect adolescents’ increased sugar intake. The findings are helpful to broaden the options for designing and developing interventions to decrease SSB and sugary snack consumption by adolescents.
Change in hyper-palatable food availability in the US food system over 30 years: 1988–2018
Authors: Demeke Saron , Rohde Kaitlyn , Chollet-Hinton Lynn , Sutton Cassandra , Kong Kai Ling , Fazzino Tera L 
Published: May 2022

AbstractObjective:To quantify the change in availability of hyper-palatable foods (HPF) in the US foods system over 30 years (1988–2018).Design:Three datasets considered representative of the US food system were used in analyses to represent years 1988, 2001 and 2018. A standardised definition from Fazzino et al. (2019) that specifies combinations of nutrients was used to identify HPF.Setting:Analysis of food-item level data was conducted. Differences in the prevalence of HPF were characterised by Cochran’s Q and McNemar’s tests. Generalised linear mixed models with a fixed effect for time and random intercept for food item estimated change in the likelihood that a food was classified as hyper-palatable over time.Participants:No participant data were used.Results:The prevalence of HPF increased 20 % from 1988 to 2018 (from 49 % to 69 %; P < 0·0001). The most prominent difference was in the availability of HPF high in fat and Na, which evidenced a 17 % higher prevalence in 2018 compared with 1988 (P < 0·0001). Compared with 1988, the same food items were >2 times more likely to be hyper-palatable in 2001, and the same food items were >4 times more likely to be classified as hyper-palatable in 2018 compared with 1988 (P values < 0·0001).Conclusions:The availability of HPF in the US food system increased substantially over 30 years. Existing food products in the food system may have been reformulated over time to enhance their palatability.
IS CAUSAL REASONING HARDER THAN PROBABILISTIC REASONING?
Authors: MOSSÉ MILAN , IBELING DULIGUR , ICARD THOMAS 
Published: May 2022

AbstractMany tasks in statistical and causal inference can be construed as problems of entailment in a suitable formal language. We ask whether those problems are more difficult, from a computational perspective, for causal probabilistic languages than for pure probabilistic (or “associational”) languages. Despite several senses in which causal reasoning is indeed more complex—both expressively and inferentially—we show that causal entailment (or satisfiability) problems can be systematically and robustly reduced to purely probabilistic problems. Thus there is no jump in computational complexity. Along the way we answer several open problems concerning the complexity of well-known probability logics, in particular demonstrating the
${\exists \mathbb {R}}$
-completeness of a polynomial probability calculus, as well as a seemingly much simpler system, the logic of comparative conditional probability.
Revealing Bias of Cloud Radiative Effect in WRF Simulation: Bias Quantification and Source Attribution
Authors: Shan Yunpeng , Shi Hongrong , Fan Jiwen , Lin Lin , Gao Lan , He Cenlin , Gao Meng , Miao Lijuan , Zhang Lei , Xia Xiangao , Chen Hongbin 
Published: May 2022

AbstractAccurate prediction of cloud radiative effect (CRE) is important to weather forecast and climate projection, and solar energy production—a major renewable energy source toward decarbonization. Here, we evaluate the capability of the Weather Research and Forecast (WRF) model to simulate solar irradiance on a short‐term timescale (days) against observations in a remote region in north China. Results illustrate that our WRF simulation systematically underestimates the CRE and three error sources are identified: (a) incorrectly predicted cloud occurrence (i.e., missed clouds and false clouds), (b) underestimated cloud condensate mass, and (c) simplified parameterization of solar irradiance extinction. The incorrect cloud occurrence is the leading bias source, because it occurred most frequently and results in a substantial magnitude of errors. The cloud occurrence bias is subject to simulations of large‐scale air ascends and planetary boundary layer turbulence. Even when cloud occurrence is correctly simulated, our WRF simulation still underestimates CRE. This is because (a) the shallow convection scheme and cloud microphysics scheme underestimate cloud condensate mass and (b) cloud water path that feeds in the radiation scheme neglects precipitating cloud condensates (i.e., raindrops and graupels). Furthermore, an evaluation of cases with small bias in cloud condensate mass and effective radius demonstrates the parameterization of solar irradiance extinction for clouds induces a mean root mean square deviation of 110 W/m2. A possible reason is the simplified calculation of cloud extinction efficiency by applying Monte Carlo integration. The gained knowledge is important for understanding CRE simulation and solar irradiance forecast.
The Dashui Subduction Complex in the Eastern Tianshan‐Beishan Orogen (NW China): Long‐Lasting Subduction‐Accretion Terminated by Unique Mid‐Triassic Strike‐Slip Juxtaposition of Arcs in the Southern Altaids
Authors: Wang Kai , Xiao Wenjiao , Windley Brian F. , Mao Qigui , Ji Wenhua , Sang Miao , Huang Peng , Wang Ping 
Published: May 2022

AbstractComprehensive studies of the tectonic nature and the formation age of the Dashui complex in the Eastern Tianshan‐Beishan Orogen may address and help to better understand the complicated accretionary tectonics of the southern Altaids. Based on our detailed geological mapping, structural analysis, and understanding of new geochemistry and detrital zircon U‐Pb dating of critical samples, the Dashui complex can be subdivided into one mélange (Central Zone) and two units of forearc basin and slope basin (Northern and Southern Zones). The Northern Zone is composed of debris flows and turbidites. The Central Zone has a “block‐in‐matrix” structure, and the blocks of basalts have E‐MORB or N‐MORB geochemical signatures. The Southern Zone is characterized by debris flows. Therefore, we name these rocks Dashui subduction complex. Detrital zircons from the three zones show a major single age peak at ca. 460–420 Ma and a minor age peak at ca. 280–260 Ma, and the maximum depositional ages from north to south are: 264, 244 and 246 Ma, respectively, indicate that the Dashui subduction complex developed independently within an overall intra‐oceanic arc until ca. 244 Ma, and there must have been a large‐scale tectonic separation between the Central Tianshan Arc to the north and the Shuangyingshan Arc to the south. The structural geometry and kinematics of the Dashui complex and adjacent areas indicate that this complex likely experienced syn‐subduction thrusting and strike‐slip deformation. In particular, the late Xingxingxia strike‐slip faulting finally juxtaposed the Central Tianshan, Mazongshan, and Shuangyingshan arcs.
Particle Nonresolved DNS‐DEM Study of Flocculation Dynamics of Cohesive Sediment in Homogeneous Isotropic Turbulence
Authors: Yu Minglan , Yu Xiao , Balachandar S. 
Published: May 2022

AbstractA two‐phase Euler‐Lagrangian framework was implemented to investigate the flocculation dynamics of cohesive sediment in isotropic turbulence. The primary particles are modeled as sticky soft spheres using the discrete element method (DEM). The attractive van der Waals forces are modeled by the DLVO theory and the JKR adhesive contact theory. The near steady state equilibrium floc size distribution (FSD) strongly depends on the ratio of the turbulent shear to the floc strength (or particle stickiness). When turbulence is strong, a single peak around the Kolmogorov length scale appears in the FSD, and the distribution fits the Weibull distribution well. A power‐law floc size distribution develops when the floc strength is greater than the destabilizing effect of turbulent shear. Sediment concentration does not significantly affect the shape of FSD or the average floc size. The average apparent floc settling velocity Ws increases with the average floc size. Fractal dimension of flocs decreases with the floc size following a power‐law relation for large flocs. Settling velocity of flocs as a function of floc size also follows a power‐law relation. Deviation from the power‐law relationship is found for large flocs because of their porous nature. At equilibrium stage, the construction by aggregation is balanced with the destruction by breakup, and the construction by breakup is balanced with the destruction by aggregation. The aggregation kernel by turbulent shear and power‐law breakup kernel can describe the dynamics reasonably well for the flocculation of cohesive sediment in homogeneous isotropic turbulence.
Diagnostic Framework for Evaluating How Parametric Uncertainty Influences Agro‐Hydrologic Model Projections of Crop Yields Under Climate Change
Authors: Karimi Tina , Reed Patrick , Malek Keyvan , Adam Jennifer 
Published: May 2022

AbstractDespite the prevalence of climate change assessments of crop yields, there are significant limits to our understanding of how parametric uncertainty in the underlying agro‐hydrologic models as well as the stationarity assumptions tacit to their commonly employed calibration procedures are influencing projections. This study addresses this knowledge gap by clarifying how parametric uncertainty in agro‐hydrologic models influences yield projections under changing future climate. We focus on rain‐fed winter wheat systems in the drylands of United States Pacific Northwest. We use a tightly coupled agro‐hydrologic model, VIC‐CropSyst, as a representative of this class of models. Our contributed diagnostic global sensitivity analysis framework identifies differences in how influential factors (e.g., temperature during early growth stages or the growing degree‐day required to reach peak leaf area index) vary across zones during historical and future periods. Our results show that the dominant parametric controls for yield projection and their sensitivities change subject to agro‐climatic zones and differences in the specific temperature‐precipitation trends in future climate scenarios. Our results also indicate that the stationarity assumptions tacit to using historical observations to calibrate agro‐hydrologic model parameters and their subsequent use in future yield projections may introduce significant bias. Employing the stationarity assumption in future projections problematically ignores how shifts in climate influence the relative dominance of underlying agro‐hydrologic processes in the model. This study's contributed diagnostic exploratory modeling framework has promise for advancing our understanding of how calibration, parametric uncertainties, and climate induced changes in the dominance of model biophysical processes shape crop yield projections.
Modelling sexual violence in male rats: the sexual aggression test (SxAT)
Authors: de M. Oliveira Vinícius E. , de Jong Trynke R. , Neumann Inga D. 
Published: May 2022

AbstractSexual assault and rape are crimes that impact victims worldwide. Although the psychosocial and eco-evolutionary factors associated with this antisocial behavior have repeatedly been studied, the underlying neurobiological mechanisms are still largely unknown. Here, we established a novel paradigm to provoke and subsequently assess sexual aggression (SxA) in adult male Wistar rats: the sexual aggression test (SxAT). Briefly, male Wistar rats are sexually aroused by a receptive female, which is exchanged by a non-receptive female immediately after the first intromission. This protocol elicits forced mounting and aggressive behavior toward the non-receptive female to different degrees, which can be scored. In a series of experiments we have shown that SxA behavior is a relatively stable trait in rats and correlates positively with sexual motivation. Rats with innate abnormal anxiety and aggressive behavior also show abnormal SxA behavior. In addition, central infusion of oxytocin moderately inhibits aggressive behavior, but increases forced mounting. Finally, we identified the agranular insular cortex to be specifically activated by SxA, however, inhibition of this region did not significantly alter behavior in the SxAT. Altogether, the SxAT is a paradigm that can be readily implemented in behavioral laboratories as a valuable tool to find answers regarding the biological mechanisms underlying SxA in humans, as well as social decision-making in general.