bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Diccionario Maya Cordemex: A Cooperative Project in Mayan Linguistics
Authors: Moseley Edward H. 
Published: October 2022

In May 1975, Alfredo Barrera Vásquez, noted scholar of the Mayan language and culture, was meeting with a group of graduate students; suddenly he looked at his watch and said: “In a few minutes I must go to the dictionary.”Only then did I become aware of a project that, after six years of intensive work, would result in one of the most valuable contributions to the field of Mayan linguistics in the twentieth century. Each weekday at four p.m., a group of highly talented specialists met in a small building in Mérida to labor on the dictionary. The team worked with a sense of dedication and purpose, and those of us fortunate enough to visit the project became filled with a feeling of excitement. The resulting publication, issued in January 1980, was the Diccionario Maya Cordemex: Maya-Español, Español-Maya (Mérida, Yucatán: Ediciones Cordemex, 1980). It is not the first dictionary of the Mayan language, but is in many ways the culmination of all previous studies relating to the subject.
Differential Migration of Cuban Social Races: A Review and Interpretation of the Problem
Authors: Aguirre Benigno E. 
Published: October 2022

In the aftermath of the 1959 revolutionary triumph there began a massive impelled migration to the United States, paralleled in Cuban history only by the great exodus during the nineteenth-century wars of independence. Close to 500,000 Cubans had migrated to the United States by 1972.The migration has shifted in size and has occurred intermittently since 1959, a consequence of the turbulent relations between the United States and Cuban governments. From January 1959 to October 1962, regular commercial flights existed between the United States and Cuba. During much of this period, American visas could be obtained in the United States embassy in Havana and in the Santiago de Cuba consulate. However, after diplomatic relations were severed (3 January 1961), the United States government generally waived the visa requirements for Cubans desiring to migrate. During this period, 153,534 Cubans registered with the Miami Cuban Refugee Center arld close to 200,000 had arrived in the United States by the time of the 1962 October missile crisis.
Traversing the Social Pyramid: A Comparative Review of Income Distribution in Latin America
Authors: Weisskoff Richard , Figueroa Adolfo 
Published: October 2022

DUKE:
Her madness hath the oddest frame of sense,Such a dependency of thing on thing,As e'er I heard in madness.ISABEL:
O a gracious Duke,Harp not on that! nor do not banish reasonFor inequality, but let your reason serveTo make the truth appear where it seems hidAnd hide the false seems true!Shakespeare, Measure for MeasureThe study of the distribution of income summarizes a nation's social organization and the outcome of the forces of social change. The measurement of income distribution itself yields a type of social scorecard, the resolution of claims by competing groups for the economy's output. As an indication of social justice, income distribution measures as well the extent to which different groups share in a nation's economic progress.
An improved Kalman particle swarm optimization for modeling and optimizing of boiler combustion characteristics
Authors: Liang Jing , Guo Hao , Chen Ke , Yu Kunjie , Yue Caitong , Li Xia 
Published: October 2022

AbstractWith the rapid development of the national economy, the demand for electricity is also growing. Thermal power generation accounts for the highest proportion of power generation, and coal is the most commonly used combustion material. The massive combustion of coal has led to serious environmental pollution. It is significant to improve energy conversion efficiency and reduce pollutant emissions effectively. In this paper, an extreme learning machine model based on improved Kalman particle swarm optimization (ELM-IKPSO) is proposed to establish the boiler combustion model. The proposed modeling method is applied to the combustion modeling process of a 300 MWe pulverized coal boiler. The simulation results show that compared with the same type of modeling method, ELM-IKPSO can better predict the boiler thermal efficiency and NOx emission concentration and also show better generalization performance. Finally, multi-objective optimization is carried out on the established model, and a set of mutually non-dominated boiler combustion solutions is obtained.
Colony stimulating factor 2 protects the preimplantation bovine embryo from heat shock
Authors: Sosa Froylan , Hansen Peter J. 
Published: October 2022

SummaryHeat stress can have severe deleterious effects on embryo development and survival. The present study evaluated whether CSF2 can protect the developmental competence of the bovine embryo following exposure to a heat shock of 41°C at the zygote and morula stages. In the first experiment, putative zygotes and 2-cell embryos were assigned to receive either 10 ng/ml CSF2 or vehicle, and then cultured for 15 h at either 38.5°C or 41°C and then at 38.5°C until day 7.5. Heat shock reduced blastocyst development for embryos treated with vehicle but not for embryos cultured with CSF2. In the second experiment, day 5 embryos (morula) were treated with CSF2 or vehicle and then cultured for 15 h at either 38.5°C or 41°C and then at 38.5°C until day 7.5. Temperature treatment did not affect development to the blastocyst stage and there was no effect of CSF2 treatment or the interaction. Results indicate that CSF2 can reduce the deleterious effects of heat shock at the zygote or two-cell stage when the embryo is transcriptionally inactive.
Collaborating on Research with Undergraduate Students: A Comparative Institutional-Racial Analysis
Authors: Mangum Maruice 
Published: October 2022

ABSTRACTThis article describes my experiences in collaborating with undergraduate students on research projects, including published works in peer-reviewed outlets. The article discusses the courses and assignments that engendered the collaborations and compares the institutions and students. By describing several significant similarities and differences, I compare and contrast white students in The Midwest at Predominantly White Institutions with African American students at Historically Black Colleges and Universities in The South.
The role of integrin beta in schizophrenia: a preliminary exploration
Authors: He Binshan , Wang Yuhan , Li Huang , Huang Yuanshuai 
Published: October 2022

AbstractIntegrins are transmembrane heterodimeric (αβ) receptors that transduce mechanical signals between the extracellular milieu and the cell in a bidirectional manner. Extensive research has shown that the integrin beta (β) family is widely expressed in the brain and that they control various aspects of brain development and function. Schizophrenia is a relatively common neurological disorder of unknown etiology and has been found to be closely related to neurodevelopment and neurochemicals in neuropathological studies of schizophrenia. Here, we review literature from recent years that shows that schizophrenia involves multiple signaling pathways related to neuronal migration, axon guidance, cell adhesion, and actin cytoskeleton dynamics, and that dysregulation of these processes affects the normal function of neurons and synapses. In fact, alterations in integrin β structure, expression and signaling for neural circuits, cortex, and synapses are likely to be associated with schizophrenia. We explored several aspects of the possible association between integrin β and schizophrenia in an attempt to demonstrate the role of integrin β in schizophrenia, which may help to provide new insights into the study of the pathogenesis and treatment of schizophrenia.
Food availability and affordability in a Mediterranean urban context: associations by store type and area-level socio-economic status
Authors: Fernández-Escobar Carlos , Díez Julia , Martínez-García Alba , Bilal Usama , O’Flaherty Martin , Franco Manuel 
Published: October 2022

AbstractObjective:Although food environments have been highlighted as potentially effective targets to improve population diets, evidence on Mediterranean food environments is lacking. We examined differences in food availability and affordability in Madrid (Spain) by store type and area-level socio-economic status (SES).Design:Cross-sectional study. Trained researchers conducted food store audits using the validated Nutrition Environment Measures Survey in Stores for Mediterranean contexts (NEMS-S-MED) tool to measure the availability and price of twelve food groups (specific foods = 35). We computed NEMS-S-MED scores and summarised price data with a Relative Price Index (RPI, comparing prices across stores) and an Affordability Index (normalising prices by area-level income). We compared the availability and affordability of ‘healthier–less healthy’ food pairs, scores between food store types (supermarkets, specialised, convenience stores and others) and area-level SES using ANOVA and multi-level regression models.Setting:City of Madrid. 2016 and 2019 to cover a representative sample.Participants:Food stores within a socio-economically diverse sample of sixty-three census tracts (n 151).Results:Supermarkets had higher food availability (37·5/49 NEMS-S-MED points), compared to convenience stores (13·5/49) and specialised stores (8/49). Supermarkets offered lower prices (RPI: 0·83) than specialised stores (RPI: 0·97) and convenience stores (RPI: 2·06). Both ‘healthy’ and ‘less healthy’ items were more available in supermarkets. We found no differences in food availability or price by area-level SES, but affordability was higher in higher-income areas.Conclusions:Supermarkets offered higher food availability and affordability for healthy and less healthy food items. Promoting healthy food availability through supermarkets and specialised stores and/or limiting access to convenience stores are promising policy options to achieve a healthier food environment.
Response to Bishop Keith Joseph’s ‘The Challenge of Gafcon to the Unity of the Anglican Communion’
Authors: Condie Richard 
Published: October 2022

AbstractThis is a response by Bishop Richard Condie, the Bishop of Tasmania and Chairman of Gafcon Australia, to the article by Bishop Keith Joseph (the Bishop of North Queensland, Australia) published in the Journal of Anglican Studies in May 2022. It engages with the nature and limits of unity in the Anglican Church before discussing the unique context of the Jerusalem Declaration and recent developments in the Anglican Church of Australia.
The authoritarian challenge: liberal thinking on autocracy and international relations, 1930–45
Authors: Draper Matthew , Haggard Stephan 
Published: October 2022

AbstractThe return of authoritarian great powers, the slowing of the democratic wave, and outright reversion to authoritarian rule pose important questions for international theory. What are the implications of an international system populated with more autocracies? This question was posed by a diverse array of social scientists, public intellectuals, and policy analysts in response to the autocratic wave in Europe in the 1920s and 1930s. We show that a series of conversations emanating from quite diverse intellectual priors – from Christian realists to international lawyers and disaffected Marxists – converged on the risks these autocratic regimes posed to democratic regimes and the international order they sought to forge. These risks included unconstrained rulers, an inability to sustain international commitments and political processes that undermined rational deliberation at home and spread disinformation abroad. The reading of this work suggests an under-appreciated strand of liberal international relations theory, and these debates have direct implications for liberal arguments about the democratic peace. Rather than theorizing why democracies avoid war, they underscore the importance of understanding why authoritarian and democratic countries are particularly prone to conflict.
Concurrence of novel mutations causing Gilbert’s and Dubin–Johnson syndrome with poor clinical outcomes in a Han Chinese family
Authors: Zhou Tai-Cheng , Li Xiao , Li Hui , Liu Feng-Wei , Zhang Si-Hang , Fan Jing-Hua , Yang Wen-Xiu , Yang Ya-Li , Zhang Liang , Wei Jia 
Published: October 2022

AbstractDual-hereditary jaundice (Dubin–Johnson syndrome (DJS) and Gilbert’s syndrome (GS)) is a rare clinical entity resulting from defects of the ATP binding cassette subfamily C member 2 (ABCC2) and UDP glucuronosyltransferase family 1 member A1 (UGT1A1) genes with autosomal recessive inheritance. In this study, we aimed to investigate the mutation profiles and characterize the phenotypes in a Han Chinese family with DJS and GS. Genetic screening for variants in the ABCC2 and UGT1A1, immunohistochemistry for expression of ABCC2, and histopathological examination were carried out. The proband and his brother had unconjugated and conjugated hyperbilirubinemia after birth. The proband’s sister had only conjugated hyperbilirubinemia after birth. The proband developed into pleural effusions and ascites, pericardial thickening, intrahepatic and extrahepatic biliary duct dilatation, and enlarged gallbladder at age 50. Hepatocellular carcinoma occurred in the proband’s brother at age 46. Seven compound defects of the ABCC2 gene [c.2414delG, p.(Ile1489Gly), p.(Thr1490Pro), and p.(Ile1491Gln)] and the UGT1A1 gene (c.-3279T>G, p.(Gly71Arg), and p.(Pro451Leu)) were identified in family members. Accumulation of pigment in hepatocytes characteristic of that in DJS was present in the proband and his brother. Expression of ABCC2 protein was markedly diminished in the patient’s liver. Our results show a different genetic profile of DJS and GS in a Han Chinese family, indicating a more complex pattern of dual-hereditary jaundice among different populations. The present study illuminates the underpinnings of DJS and GS and extends the mutation profiles and phenotypes of these two syndromes in dual-hereditary jaundice.
Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins
Authors: van Leeuwen Jenna E. , Ba-Alawi Wail , Branchard Emily , Cruickshank Jennifer , Schormann Wiebke , Longo Joseph , Silvester Jennifer , Gross Peter L. , Andrews David W. , Cescon David W. , Haibe-Kains Benjamin , Penn Linda Z. , Gendoo Deena M. A. 
Published: October 2022

AbstractStatins, a family of FDA-approved cholesterol-lowering drugs that inhibit the rate-limiting enzyme of the mevalonate metabolic pathway, have demonstrated anticancer activity. Evidence shows that dipyridamole potentiates statin-induced cancer cell death by blocking a restorative feedback loop triggered by statin treatment. Leveraging this knowledge, we develop an integrative pharmacogenomics pipeline to identify compounds similar to dipyridamole at the level of drug structure, cell sensitivity and molecular perturbation. To overcome the complex polypharmacology of dipyridamole, we focus our pharmacogenomics pipeline on mevalonate pathway genes, which we name mevalonate drug-network fusion (MVA-DNF). We validate top-ranked compounds, nelfinavir and honokiol, and identify that low expression of the canonical epithelial cell marker, E-cadherin, is associated with statin-compound synergy. Analysis of remaining prioritized hits led to the validation of additional compounds, clotrimazole and vemurafenib. Thus, our computational pharmacogenomic approach identifies actionable compounds with pathway-specific activities.
Ribosome-mediated biosynthesis of pyridazinone oligomers in vitro
Authors: Lee Joongoo , Coronado Jaime N. , Cho Namjin , Lim Jongdoo , Hosford Brandon M. , Seo Sangwon , Kim Do Soon , Kofman Camila , Moore Jeffrey S. , Ellington Andrew D. , Anslyn Eric V. , Jewett Michael C. 
Published: October 2022

AbstractThe ribosome is a macromolecular machine that catalyzes the sequence-defined polymerization of L-α-amino acids into polypeptides. The catalysis of peptide bond formation between amino acid substrates is based on entropy trapping, wherein the adjacency of transfer RNA (tRNA)-coupled acyl bonds in the P-site and the α-amino groups in the A-site aligns the substrates for coupling. The plasticity of this catalytic mechanism has been observed in both remnants of the evolution of the genetic code and modern efforts to reprogram the genetic code (e.g., ribosomal incorporation of non-canonical amino acids, ribosomal ester formation). However, the limits of ribosome-mediated polymerization are underexplored. Here, rather than peptide bonds, we demonstrate ribosome-mediated polymerization of pyridazinone bonds via a cyclocondensation reaction between activated γ-keto and α-hydrazino ester monomers. In addition, we demonstrate the ribosome-catalyzed synthesis of peptide-hybrid oligomers composed of multiple sequence-defined alternating pyridazinone linkages. Our results highlight the plasticity of the ribosome’s ancient bond-formation mechanism, expand the range of non-canonical polymeric backbones that can be synthesized by the ribosome, and open the door to new applications in synthetic biology.
Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer
Authors: Villar Victor H. , Allega Maria Francesca , Deshmukh Ruhi , Ackermann Tobias , Nakasone Mark A. , Vande Voorde Johan , Drake Thomas M. , Oetjen Janina , Bloom Algernon , Nixon Colin , Müller Miryam , May Stephanie , Tan Ee Hong , Vereecke Lars , Jans Maude , Blancke Gillian , Murphy Daniel J. , Huang Danny T. , Lewis David Y. , Bird Thomas G. , Sansom Owen J. , Blyth Karen , Sumpton David , Tardito Saverio 
Published: October 2022

AbstractGlutamine synthetase (GS) activity is conserved from prokaryotes to humans, where the ATP-dependent production of glutamine from glutamate and ammonia is essential for neurotransmission and ammonia detoxification. Here, we show that mammalian GS uses glutamate and methylamine to produce a methylated glutamine analog,N5-methylglutamine. Untargeted metabolomics revealed that liver-specific GS deletion and its pharmacological inhibition in mice suppress hepatic and circulating levels ofN5-methylglutamine. This alternative activity of GS was confirmed in human recombinant enzyme and cells, where a pathogenic mutation in the active site (R324C) promoted the synthesis ofN5-methylglutamine over glutamine.N5-methylglutamine is detected in the circulation, and its levels are sustained by the microbiome, as demonstrated by using germ-free mice. Finally, we show that urine levels ofN5-methylglutamine correlate with tumor burden and GS expression in a β-catenin-driven model of liver cancer, highlighting the translational potential of this uncharacterized metabolite.
Caveolin-1 is a primary determinant of endothelial stiffening associated with dyslipidemia, disturbed flow, and ageing
Authors: Le Master Elizabeth , Paul Amit , Lazarko Dana , Aguilar Victor , Ahn Sang Joon , Lee James C. , Minshall Richard D. , Levitan Irena 
Published: October 2022

AbstractEndothelial stiffness is emerging as a major determinant in endothelial function. Here, we analyzed the role of caveolin-1 (Cav-1) in determining the stiffness of endothelial cells (EC) exposed to oxidized low density lipoprotein (oxLDL) under static and hemodynamic conditions in vitro and of aortic endothelium in vivo in mouse models of dyslipidemia and ageing. Elastic moduli of cultured ECs and of the endothelial monolayer of freshly isolated mouse aortas were measured using atomic force microscopy (AFM). We found that a loss of Cav-1 abrogates the uptake of oxLDL and oxLDL-induced endothelial stiffening, as well as endothelial stiffening induced by disturbed flow (DF), which was also oxLDL dependent. Mechanistically, Cav-1 is required for the expression of CD36 (cluster of differentiation 36) scavenger receptor. Genetic deletion of Cav-1 abrogated endothelial stiffening observed in the DF region of the aortic arch, and induced by a high fat diet (4–6 weeks) and significantly blunted endothelial stiffening that develops with advanced age. This effect was independent of stiffening of the sub-endothelium layer. Additionally, Cav-1 expression significantly increased with age. No differences in elastic modulus were observed between the sexes in advanced aged wild type and Cav-1 knockout mice. Taken together, this study demonstrates that Cav-1 plays a critical role in endothelial stiffening induced by oxLDL in vitro and by dyslipidemia, disturbed flow and ageing in vivo.
Protection status, human disturbance, snow cover and trapping drive density of a declining wolverine population in the Canadian Rocky Mountains
Authors: Barrueto Mirjam , Forshner Anne , Whittington Jesse , Clevenger Anthony P. , Musiani Marco 
Published: October 2022

AbstractProtected areas are important in species conservation, but high rates of human-caused mortality outside their borders and increasing popularity for recreation can negatively affect wildlife populations. We quantified wolverine (Gulo gulo) population trends from 2011 to 2020 in > 14,000 km2 protected and non-protected habitat in southwestern Canada. We conducted wolverine and multi-species surveys using non-invasive DNA and remote camera-based methods. We developed Bayesian integrated models combining spatial capture-recapture data of marked and unmarked individuals with occupancy data. Wolverine density and occupancy declined by 39%, with an annual population growth rate of 0.925. Density within protected areas was 3 times higher than outside and declined between 2011 (3.6 wolverines/1000 km2) and 2020 (2.1 wolverines/1000 km2). Wolverine density and detection probability increased with snow cover and decreased near development. Detection probability also decreased with human recreational activity. The annual harvest rate of ≥ 13% was above the maximum sustainable rate. We conclude that humans negatively affected the population through direct mortality, sub-lethal effects and habitat impacts. Our study exemplifies the need to monitor population trends for species at risk—within and between protected areas—as steep declines can occur unnoticed if key conservation concerns are not identified and addressed.