bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contamination Vulnerability Assessment of the Bambuí Karst Aquifer, in the Terra Ronca Region - Goiás, Brazil
Authors: Amaral Ana Karolyna Nunes , Silva Gisele Bispo , Rosa Lucas Espíndola , Cherem Luis Felipe Soares , Momoli Renata Santos , Zancopé Márcio Henrique de Campos 
Published: October 2022

Abstract

Karstic environments are characterized as areas of intense rock dissolution, which allows the generation of several typical features, such as sinkholes, resurgences, caves, and dolines. The spatial distribution of these features is of great importance to identify the contamination vulnerability of karst aquifers and serve as a basis for the application of assessment methods. This study aimed to identify and classify the areas vulnerable to underground contamination in the karstic region of the Terra Ronca State Park (PETeR) and its surroundings. The method chosen was the COP, which assesses the physical conditions of the environment (relief, lithology, soils, precipitation, karst features, and vegetation) to determine the areas naturally vulnerable to contamination. The analyses were performed in a GIS environment. The results indicated five categories of areas vulnerable to groundwater contamination: Very High to High (3.14%), Moderate (16.21%), and Low to Very Low (80.62%). The Terra Ronca State Park was the analysis unit with the highest vulnerability in the region (9.91%), due to the concentration of karstic features in the area. The acquired results aim to help in the underground water resources conservation as well as the speleological patrimony.
Control of Meloidogyne javanica with Pleurotus djamor spent mushroom substrate
Authors: Lopes Ana Daniela , Gomes Simone , Dias-Arieira Claudia Regina , Schwengber Raiane Pereira , Carpi Maria Claudia Guimarâes 
Published: October 2022

Abstract

Background
The interest in the development of ecologically correct products associated with the loss of efficiency of chemical nematicides for the control management of this pest is growing. Thus, the adoption of biological control or the use of biopesticides are excellent options for these products. Spent mushroom substrate (SMS), a product of the mushroom production industry, has great potential for biological control due to its high levels of mycelium, residual enzymes, high humidity and unique microbiota that may contain other nematode antagonists. For this reason, this study aimed to evaluate the potential of spent mushroom substrate (SMS) from Pleurotus djamor cultivation in the control of Meloidogyne javanica in lettuce and assess its effects on plant resistance enzymes and soil biological activity.
Results
SMS reduced nematode reproduction, and a plateau was reached at SMS concentrations above 15%. Higher concentrations of SMS caused phytotoxicity in lettuce, with reduction of vegetative variables, chlorophyll content and nitrogen balance in the leaves; however, SMS increases the anthocyanin content. Guaiacol peroxidase activity was highest in treatments containing 0% and 30% SMS and phenylalanine ammonia-lyase activity was highest in the 60% SMS treatment, suggesting induction of resistance to M. javanica. The maximum soil basal respiration was estimated to be achieved with 25.75% SMS, whereas the maximum soil metabolic quotient was estimated to be achieved with 8.8% SMS. Soil biomass carbon increased with increasing SMS proportion.
Conclusions
Spent substrate from P. djamor cultivation incorporated in soil at proportions of 15, 30, 45 e 60% is efficient in controlling M. javanica in lettuce.
A novel Sarcopenic Obesity Rat Model Based on Ageing and High-fat Diet
Authors: Zhu Huan , Sun Qianqian , Tang Huiyu , Chen Yanyu , Tan Ke , Xu Xu , Wang Shuang 
Published: October 2022

Abstract
Background
Sarcopenic obesity (SO) is defined as a combination of obesity and sarcopenia, leading to serious health consequences. However, lack of animal model has hampered research into this disorder.
Methods
Twelve-months-old male Sprague Dawley(SD) rats were fed a high-fat diet (HFD) from early to late adulthood, and their phenotypes were evaluated by determining age-related changes in muscle mass and strength, histopathology, HFD-induced adiposity, and metabolic parameter disturbances. The experimental animals results were compared with those obtained for two-month-old and twelve-month -old rats who were fed a standard diet.
Results
Aged non-obese rats (20 months, and fed standard diet) showed a decline in quadriceps cross-sectional area/body weight, forelimb grip strength, myofibre cross-sectional area and number, and intermyofibrillar mitochondria number(IFM), accompanied by increased myocyte apoptosis, without metabolic disorder. However, aged obese rats (20 months, and fed high-fat diet) exhibited increased visceral fat, remarkable glycolipid metabolic disorders, and insulin resistance, a more prominent loss of muscle mass and strength, accompanied with a more pronounced decline in myofibre number, IFM, increase in myocyte apoptosis.
Conclusion
Taken together, aged non-obese rats showed a typical sarcopenic phenotype with ageing. Obesity concomitant with sarcopenia aggravated the animal condition through visceral fat accumulation and insulin resistance. These results support the idea that the aged obese SD rat model represents certain features common with SO in humans and lays the foundation for further studies into the disorder.
Cahn-hilliard-navier-stokes Equations With Nonhomogeneous Boundary: Existence, Uniqueness, Regularity
Authors: BAG MANIKA , BISWAS TANIA , Dharmatti Sheetal 
Published: October 2022

Abstract
The evolution of two isothermal, incompressible, immisible fluids in a bounded domain is governed by Cahn-Hilliard-Navier-Stokes equations (CHNS System). In this work we study the well-posedness results for CHNS system with nonhomogeneous boundary condition for the velocity equation. We obtain existence of global weak solutions in the two dimensional bounded domain using semi Galerkin approximation. We further prove the continuous dependence of the solution on initial conditions and boundary data that will provide the uniqueness of the weak solution. The existence of strong solutions is also established in this work.
Mathematics Subject Classification (2020): 35A01, 35B65, 35Q35, 76D03, 76T06.
Immune checkpoints expression patterns predict prognosis and immune microenvironment remodeling in triple-negative breast cancer
Authors: Zhang Jinguo , Jin Hongwei , Pan Shuaikang , Han Chaoqiang , Sun Qingqing , Han Xinghua 
Published: October 2022

Abstract
Targeting immune checkpoint molecules holds great promise for triple-negative breast cancer (TNBC). However, the expression landscape of immune checkpoint genes (ICGs) in TNBC remains largely unknown. Herein, we systematically investigated the ICGs expression patterns in 422 TNBC samples. Molecular typings based on the ICGs expression profiled were identified and the associations between ICGs molecular typing and tumor immune characteristics, clinical significance, and response to immune checkpoint inhibitors (ICIs) were further explored. We identified two ICGs clusters and two ICGs-related gene clusters, which were were involved in different survival outcomes, biological roles and infiltration levels of immune cells. We also established and ICGs Riskscore quantification system to assess the ICGs expression patterns for individuals. TNBC patients with lower ICGs Riskscore were characterized by increased immune cell infiltration, favorable clinical outcome and high sensitivity to ICIs therapy. We also developed a nomogram model combining clinicopathological variables to predict OS in TNBC and the proposed nomogram presents good performance. Genomic features analysis revealed that high ICGs-related riskscore group presented an increased tumor mutation burden compared with the low ICGs-related riskscore group. Collectively, dissecting the ICGs expression patterns not only provides a new insight of subtype of TNBC but also deepens the understanding of ICGs in tumor immune microenvironment.
Quality of Life Assessment in Intestinal Stoma Patients in the Saudi Population: A Cross- sectional Study
Authors: Alharbi Reem A. , Ahmad Nadeem , Alhedaithy Fatemah Yasser , Alnajim Majdoleen Dakhil N , Waheed Naima , Alessa Aisha A , Khedr Banan A , Aleissa Marriyam A 
Published: October 2022

Abstract
BACKGROUND
A stoma requires a patient's lifestyle modifications and mental adjustment. It may hinder certain Islamic rituals that new appliances might overcome. The study aimed at measuring the quality of life in the modern era of stoma care in patients with unique sociocultural characteristics.
METHODS
Patients with an intestinal stoma for > 3 weeks were included. A modified City of Hope QoL ostomy questionnaire was used with dichotomous scoring on a 0 to 10 scale; rated 0-3 as severe, 4-6 as moderate, and 7-10 as severe. Data were analyzed by student’s t-test, one-way ANOVA, Spearman’s correlation, and multivariate linear regression.
RESULTS
The response rate was 46%, with 108 patients responding. The mean age was 40.8 years, and the male-to-female ratio 1.2:1.
QoL score and that in physical and spiritual domains were 6. In the social domain, it was 7, and in the psychological, 5. The impact was severe in 2%, moderate in 61%, and minimal in 37%. Younger patients, women, and those with benign diseases or without a job had lower scores. 90% of the patients had difficulty performing religious activities, resulting in a lower score. Regression analysis showed dietary and religious factors, leak, foul odor, constipation/diarrhea, poor stoma site, depression, anxiety, and concerns for disease, future, or pouch problems as the significant quality of life predictors.
CONCLUSION
Stoma patients had multiple impediments to their life quality despite advances in stoma care. Among these, physical and religious issues were significant, but psychological factors were the leading ones. The findings indicate adopting a holistic approach to managing stoma patients to let them have fulfilling lives.
Improvement of Liquefaction Resistance and Stiffness of Sandy Soils Using Fiber and Cement
Authors: El-Zamel Ahmed , Altahrany Ayman , Elmeligy Mahmoud 
Published: October 2022

Abstract
Seismically induced liquefaction concerns natural deposits of both loose sands (Dr <50%) and fine silty sands, which can be present both in the subsoil and in the slopes at medium-low depths.
This research shows the effect of random polypropylene fibers and cement in improving the resistance to liquefaction and shear modulus of loose sand deposits. A Series of laboratory undrained cyclic strain-controlled triaxial tests and cyclic stresscontrolled triaxial tests has been conducted as per
ASTM D3999 and ASTM D5311. Cemented specimens were prepared with different cement contents up to 5% by mass of dry sand, then cured for different periods of time. The fibers were added to dry sand–cement mixtures with contents of 0%, 0.5%, and 1.0% by weight. It was found that the shear modulus and liquefaction resistance of specimens increased as the fiber content, fiber length and cement content increased. The addition of 1% polypropylene fiber(PF) to 5% cement (C)increased the shear modulus by 955.20%. The percentage of increase of shear modulus of specimens increases as the cell pressure increases. The duration of the curing period has a significant effect on the shear modulus of reinforced sand specimens. The relative density has a great effect on decreasing the generation of the excess pore water pressure.
Rufy3 regulates anti-bacterial responses by controlling endolysosomes perinuclear positioning in activated phagocytes.
Authors: Char Remy , Liu Zhuangzhuang , Davieau Marion , Jacqueline Cedric , Delgado Maria-Graciela , Chapuy Raphael , Fallet Mathieu , Chasson Lionel , Camosseto Voahirana , Strock Eva , Rua Rejane , Almeida Catarina , Su Bing , Lennon-Dumenil Ana-Maria , Roquilly Antoine , Liang Yinming , Méresse Stéphane , Gatti Evelina , pierre philippe 
Published: October 2022

Abstract
Endo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RUN and FYVE domain-containing protein 3 exists as two alternative isoforms distinguishable by the presence of a C-terminal FYVE domain and by their affinity for PtdIns(3)P on endosomal membranes. The FYVE domain-bearing isoform (iRUFY3) is preferentially expressed in immune cells and up-regulated upon activation by microbes and cytokines. iRUFY3 is necessary for ARL8b+/LAMP1+ endo-lysosomes positioning in the pericentriolar organelles cloud of LPS-activated macrophages. We show that iRUFY3 controls macrophages migration, MHC II presentation and responses to Interferon-γ while being required for Intracellular Salmonella replication. Specific inactivation of Rufy3 in phagocytes leads to aggravated pathologies in mouse upon LPS injection or bacterial pneumonia. This study highlights iRUFY3 function, as a novel modulator of immunity, controlling endo-lysosomes dynamics, and ultimately regulating the function of activated phagocytes.
The temporal positivity rate of SARS-CoV-2 in different clinical samples
Authors: Alemu Fekadu , Mulu Andargachew , Kebede Eyerusalem Solomon , Alemayehu Dawit Hailu , Seyoum Tamirayehu , Tefera Dessalegn Abeje , Assefa Gebeyehu , Tesfaye Abebech , Habte Anteneh , Bedada Gadissa , Tegene Birhanemeskel , Yeshambaw Melese , Wassie Liya , Mihret Adane , Abdissa Alemseged , Beyene Getachew Tesfaye 
Published: October 2022

Abstract

The aim of this study is to evaluate the diagnostic value of different clinical samples from humans such as blood/serum, stool, and urine as compared to the routinely used nasopharyngeal swab samples for the detection of SARS-CoV2 in COVID-19 patients. We followed COVID-19 patients for three weeks and collected samples on three occasions that is, on the day of admission to the hospital (Day zero), after one week (Day-8), and after the second week (Day-15). The data shows that on the day of the admission of the patients, NPS has a 64% positivity rate, followed by stool, urine, and serum, 38%, 18%, and 17%, respectively. And we observed a nearly similar pattern of positivity rate in the subsequent week’s samples.
A fast accurate artificial boundary condition for the Euler-Bernoulli beam
Authors: Zheng Zijun , Pang Gang 
Published: October 2022

Abstract
It is difficult to propose boundary conditions for the PDEs with higher order space derivatives like Euler-Bernoulli beam. In this paper we use a absorbing boundary condition method to solve the Cauchy problem for one-dimensional Euler-Bernoulli beam with fast convolution boundary condition which is derived through the Padé approximation for the square root function. We also introduce a constant damping term to control the error between the resulting approximation Euler-Bernoulli system and the original one. Numerical examples verify the theoretical results and demonstrate the performance for the fast numerical method.
Chase and Escape Optimization Algorithm
Authors: Eesa Adel Sabry 
Published: October 2022

AbstractThis paper proposes a new optimization algorithm called Chase and Escape (CHE). The proposed CHE is based on a hunting strategy for a group of predators attacking a group of prey. The mathematical model of CHE algorithm is built on three phases. First, the predators begin by approaching and encircling the prey from all sides. The second phase is the attacking process, where the predator decides to attack the prey. Third, is the escape process, where the prey assesses the level of threat and decides whether to escape or remain in its alert zone. To assess the performance of the proposed algorithm, it is tested and evaluated on CEC-2017 benchmark functions, and its performance is compared to different cutting-edge optimization algorithms. Experimental results and Friedman mean rank test reveal that the proposed CHE outperforms the majority of the other algorithms. Furthermore, the proposed algorithm CHE is applied to four real-world engineering problems, and the results are compared with the state-of-the-art literature. The comparative results revealed that the proposed CHE algorithm is quite promising, producing better results than most of the similar recent work in the literature.
Geroprotective activity of trans-cinnamic acid isolated from the Baikal skullcap ( Scutellaria baicalensis)
Authors: Fedorova Anastasiya , Dyshlyuk Lyubov , Milentyeva Irina , Loseva Anna , Neverova Olga , Khelef Mohammed El Amine 
Published: October 2022

Trans-cinnamic acid is a phenolic compound with a wide range of bioactive properties, including antioxidant and antibacterial effects. It also has high potential in the food and cosmetic industries. We aimed to isolate trans-cinnamic acid from the Baikal skullcap (Scutellaria baicalensis) and study its geroprotective activity on Caenorhabditis elegans nematodes used as a model organism.
Our study objects included the S. baicalensis root culture and its extract, trans-cinnamic acid isolated from the extract, and C. elegans nematodes. Trans-cinnamic acid was isolated by high-performance liquid chromatography. The acid’s geroprotective activity was studied by evaluating its effect at concentrations of 10, 50, 100, and 200 μmol/L on the lifespan, stress resistance, and reproductivity of C. elegans. For the lifespan study, the nematodes were cultivated at 20°C for 61 days. To assess their resistance to oxidative stress, 15 μL of 1M paraquat was added to each well of the plate. Thermal stress resistance was determined by raising the temperature to 33°C. For the reproductivity study, the nematodes were cultivated in the S-medium with the addition of Escherichia coli OP50 and trans-cinnamic acid at required concentrations for 72 h.
The maximum increase in lifespan (9.8%) was observed in the nematodes treated with 50 μmol/L of trans-cinnamic acid. Under oxidative stress, all the concentrations of trans-cinnamic acid increased the survival of nematodes, while under thermal stress, trans-cinnamic acid reduced the percentage of surviving nematodes. At a concentration of 100 μmol/L, trans-cinnamic acid increased the nematodes’ reproduction by 1.48 times.
Based on our data, trans-cinnamic acid isolated from S. baicalensis can be recommended as a bioactive compound with geroprotective activity. However, further research is needed on other model organisms with detailed toxicity studies.
Isolated pressure zones based on GIS as a solution for water network problems
Authors: Hariri Asli Kian , Hariri Asli Kaveh 
Published: October 2022

Abstract
One of the most important accidents for water transmission lines occur by air entrance due to water hammer into the water pipeline at sub-atmospheric transient pressure. The air can be sucked into the water system causing repeated pipe breaks in sub-atmospheric transient pressure. This work aimed to improve the advanced techniques including remote sensing (RS), and the internet of things (IoT) to control the repeated pipe breaks. According to the geospatial information systems (GIS), the relationship classes between the spatial and non-spatial data were defined for the scaled model. By GIS the location of pipe breaks and sucking air into water pipeline was recognized during fluid instabilities. The location of pipe breaks was defined by the numerical modelling based on GIS. According to numerical analysis, the Courant number was equal to 0.977. In the field test, the surge velocity was 1084 m/s. The pressure wave was detected in 0.005 s by RS facilities equipped with water hammer sensors, advanced modems, and data loggers referring to the IoT technique. The result of this work led to a reduction of the non-revenue water (NRW) and the saving of drinking water.
COVID-19 and Alzheimer's Disease: Neuroinflammation, Oxidative
Stress, Ferroptosis, and Mechanisms Involved
Authors: Pomilio Alicia B. , Vitale Arturo A. , Lazarowski Alberto J. 
Published: October 2022

Abstract:
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized
by marked cognitive decline, memory loss, and spatio-temporal troubles and, in severe
cases, lack of recognition of family members. Neurological symptoms, cognitive disturbances,
and the inflammatory frame due to COVID-19, together with long-term effects,
have fueled renewed interest in AD based on similar damage. COVID-19 also
caused the acceleration of AD symptom onset. In this regard, the morbidity and mortality
of COVID-19 were reported to be increased in patients with AD due to multiple pathological
changes such as excessive expression of the viral receptor angiotensin-converting enzyme
2 (ACE2), comorbidities such as diabetes, hypertension, or drug-drug interactions
in patients receiving polypharmacy and the high presence of proinflammatory molecules.
Furthermore, the release of cytokines, neuroinflammation, oxidative stress, and ferroptosis
in both diseases showed common underlying mechanisms, which together worsen the
clinical picture and prognosis of these patients.
Targeting Nanotechnology and Nutraceuticals in Obesity: An Updated Approach
Authors: Sharma Neelam , Behl Tapan , Singh Sukhbir , Kaur Parneet , Zahoor Ishrat , Mohan Syam , Rachamalla Mahesh , Dailah Hamed Ghaleb , Almoshari Yosif , Salawi Ahmad , Alshamrani Meshal , Aleya Lotfi 
Published: October 2022

Hypothesis:
This review article represents a brief layout of the risk factors and pathophysiology responsible for obesity, customary treatment strategies, and nanotechnology-based nutraceutical for therapeutics of obesity.

Experiments:
An exhaustive search of the literature was done for this purpose, using Google Scholar, PubMed, and ScienceDirect databases. A study of the literature was conducted using publications published in peer-reviewed journals between the years 2000 and 2022.

Findings:
This was revealed that risk factors responsible for obesity were genetic abnormalities, environmental, and socio-economic factors. Number of research articles published between 2000 and 2022 were based on phytoconstituents based nanoformulation for obesity therapeutics and therefore, have been systematically compiled in this review. Various nutraceuticals like Garcinia cambogia, quercetin, resveratrol, capsaicin, Capsicum, Curcuma longa, Camella Sinensis, Zingiber officinalis, Citrus aurantium, Aegle marmelos, Coffea canephora, Asparagus officinalis, Gardenia jasminoides, Catha edulis, Clusia nemroisa, Rosmarinus officinalis, Cirsium setidens, Betula platyphylla, Tripterygium wilfordi possessing anti-obesity actions are discussed in this review along with their patents, clinical trials as well as their nanoformulation available.

Conclusion:
This review illustrates that the nanotechnology have a great propensity to impart promising role in the delivery of phytochemicals and nutraceuticals in management of obesity conditions and other related disorders.
Therapeutic Potential of HDAC Inhibitors in the Treatment of Cardiac
Diseases: A Short Review
Authors: Tiwari Vikas , Banerjee Sanjay Kumar 
Published: October 2022

Abstract:
Protein acetylation is a reversible central mechanism to control gene expression and cell signaling events. Current evidence suggests that pharmacological inhibitors for protein deacetyla-tion have already been used in various disease conditions. Accumulating reports showed that sever-al compounds that enhance histone acetylation in cells are in both the preclinical and clinical devel-opment stages targeting non-communicable diseases, which include cancerous and non-cancerous especially cardiovascular complications. These compounds are, in general, enzyme inhibitors and target a family of enzymes- called histone deacetylases (HDACs). Since HDAC inhibitors have shown to be helpful in preclinical models of cardiac complications, further research on developing novel compounds with high efficacy and low toxicity may be essential for treating cardiovascular diseases. In this review, we have highlighted the roles of HDAC and its inhibitors in cardiac com-plications.