bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differentiation of hemangioblastoma from brain metastasis using MR amide proton transfer imaging
Authors: Kamimura Kiyohisa , Nakajo Masanori , Gohara Misaki , Kawaji Kodai , Bohara Manisha , Fukukura Yoshihiko , Uchida Hiroyuki , Tabata Kazuhiro , Iwanaga Takashi , Akamine Yuta , Keupp Jochen , Fukami Tomoaki , Yoshiura Takashi 
Published: June 2022

AbstractBackground and PurposeDifferentiation between hemangioblastoma and brain metastasis remains a challenge in neuroradiology using conventional MRI. Amide proton transfer (APT) imaging can provide unique molecular information. This study aimed to evaluate the usefulness of APT imaging in differentiating hemangioblastomas from brain metastases and compare APT imaging with diffusion‐weighted imaging and dynamic susceptibility contrast perfusion‐weighted imaging.MethodsThis retrospective study included 11 patients with hemangioblastoma and 20 patients with brain metastases. Region‐of‐interest analyses were employed to obtain the mean, minimum, and maximum values of APT signal intensity, apparent diffusion coefficient (ADC), and relative cerebral blood volume (rCBV), and these indices were compared between hemangioblastomas and brain metastases using the unpaired t‐test and Mann‐Whitney U test. Their diagnostic performances were evaluated using receiver operating characteristic (ROC) analysis and area under the ROC curve (AUC). AUCs were compared using DeLong's method.ResultsAll MRI‐derived indices were significantly higher in hemangioblastoma than in brain metastasis. ROC analysis revealed the best performance with APT‐related indices (AUC = 1.000), although pairwise comparisons showed no significant difference between the mean ADC and mean rCBV.ConclusionsAPT imaging is a useful and robust imaging tool for differentiating hemangioblastoma from metastasis.
Effects of soybean oil on rheological characteristics of dough under high hydrostatic pressure
Authors: Jia Shuqi , Cao Jian , Dai Yangyong , Cui Bo , Yuan Chao , Hou Hanxue , Ding Xiuzhen , Wang Wentao , Zhang Hui , Zhao Luping 
Published: June 2022

AbstractIn order to improve the stability of dough with soybean oil, this article explored the effect of soybean oil addition on the rheological characteristics of dough under high hydrostatic pressure. The results showed that, compared with the dough without soybean oil, the β‐sheet, disulfide bonds content, and gauche‐gauche‐gauche in the dough increased by 4.23%, 0.85 μmol/g, and 4.16%, respectively when the dough was added with 6% soybean oil, which improved the degree of cross‐linking polymerization of gluten protein and the stability of gluten network. Meanwhile, the dough had the highest elastic modulus and the lowest maximum creep compliance (6.85 × 10−4 Pa−1 ), indicating that 6% soybean oil significantly increased the elasticity and hardness of the dough. The results of short‐range ordered structure and paste properties showed that with the addition of soybean oil, the ordered structure and paste viscosity decreased with the increase of soybean oil.
A case of successful renal transplantation of Charcot‐Marie‐Tooth disease associated with FSGS due to mutation of the INF2 gene
Authors: Matsuoka Chika , Taira Yuki , Sasaki Ryo , Matsumoto Namiko , Tadokoro Koh , Nomura Emi , Kawahara Yuko , Takemoto Mami , Morihara Ryuta , Hashiguchi Akihiro , Takashima Hiroshi , Takeuchi Hidemi , Araki Motoo , Abe Koji , Yamashita Toru 
Published: June 2022

AbstractFocal and segmental areas of glomerular sclerosis (FSGS) have various subcategories. Here, we report on a 35‐year‐old man who suffered from Charcot‐Marie‐Tooth disease (CMT) with FSGS carrying the INF2 mutation (c.206 T > C, p.L69P). The INF2 mutation might cause abnormal actin filaments of the podocytes and Schwann cells, leading to CMT associated with FSGS. He successfully underwent living donor kidney transplantation from a mother with a normal INF2 gene without any serious adverse events. Following genetic testing, the identification of the INF2 mutation allows a recipient to reduce the use of immunosuppressive drugs. Genetic testing may provide a treatment plan for kidney transplantation.
USE OF CLAYSTONE, ZEOLITE, AND ACTIVATED CARBON AS A COMPOSITE TO REMOVE HEAVY METALS FROM ACID MINE DRAINAGE IN COAL MINING
Authors: Paradise Mycelia , Nursanto Edy , Nurkhamim Nurkhamim , Haq Shofa Rijalul 
Published: June 2022

Acid mine drainage is an environmental issue impairing water sources globally. Efficient and continuous treatment in mining regions is urgently required. Therefore, this research aimed to evaluate the use of claystone from coal overburden, zeolite, and activated carbon from coconut shell as a composite to remove Fe and Mn from acid mine drainage. XRD, BET, and SEM characterized the adsorbent. The X-Ray Diffraction analysis showed the types of mineral in claystone were kaolinite, zeolite: mordenite, and activated carbon: cristobalite. Composite made with three ratios (Claystone:Zeolite:Activated carbon) = 50:25:25; 25:25:50; and 25:50:25. According to the surface area analyzer, composite with a 25:25:50 ratio had the largest surface area (62,44 m2/g). SEM-EDX analysis showed that composite had porous morphology and active sites such as Al and Si. Adsorption was carried out using a hot plate stirrer with various contact time: 30,60,90,120 and 150 minutes. The results showed that composite succeeded in increasing pH from 2.6 to 7.0 and reducing Fe concentration from 13.006 to 0.1484 ppm (98,86%) and Mn concentration from 30.59 to 20.283 ppm (33,69%). The adsorption capacities of the composite were 1,286 mg/g for Fe and 1,031 mg/g for Mn. It can be concluded that composite is a good adsorbent for removing iron from acid mine drainage.
Apuntes sobre las relaciones entre materialidades y realidades digitales
Authors: R. Rossi Luis Sebastián 
Published: June 2022

Desde inicios de la década de 1990 comenzará a resquebrajarse la noción de inmaterialidad asociada a las realidades digitales. Este artículo presenta un esquema interpretativo que permite acceder a tres vertientes discursivas que han construido distintas formas de pensar las relaciones entre realidades digitales y materialidades en el campo de la comunicación. En primer lugar, el estudio se detiene en discursos que, en contacto con prácticas de diseño, inscriben como vórtice de sus problematizaciones al carácter encarnado de la producción de sentido. En segundo lugar, la investigación examina perspectivas sobre las dinámicas entre hardware y software (giro material, arqueologías de los medios), al tiempo que aborda trabajos sobre la infraestructura de los sistemas de información y de comunicación. Por último, el artículo interpela el vínculo entre materialidad de los medios (milieux), información y objetos digitales, así como sus consecuencias para pensar la individuación psíquica y colectiva en el capitalismo contemporáneo.
Gender Differences in Cervical Spine Motions and Loads With Head Supported Mass Using Finite Element Models
Authors: Purushothaman Yuvaraj , Yoganandan Narayan 
Published: June 2022

Abstract
While many studies have been conducted to delineate the role of gender in rear impact via experiments, clinical investigations, modeling, and epidemiological research, the effect of the added head mass on segmental motions has received less attention. The objective of the study is to determine the role of the head supported mass on the segmental motions and loads on the cervical spinal column from rear impact loading. The study used finite element modeling. The model was subjected to mesh convergence studies. It was validated with human cadaver experimental data by applying the rear impact acceleration pulse to the base of the spine. At all levels of the subaxial spinal column, a comparison was made between male and female spines and with and without the use of an army combat helmet. For this purpose, segmental motions, forces, and bending moments were used as biomechanical parameters. Results showed that female spines responded with increased motions than males, and the presence of a helmet increased motions and loads in males and female spines at all levels. Numerical data are given. Head supported mass affects spine responses at all levels. The present computational modeling study, from one geometry for the male spine and one geometry for the female spine (limitations are addressed in the paper), provided insights into the mechanisms of the internal load transfer with the presence of head supported mass, prevalent in certain civilian occupations and active-duty Service members in the military.
A Review of Battery Thermal Management Methods for Electric Vehicles
Authors: Ding Yuhang , Zheng Yadan , Li Songyu , Dong Tingyue , Gao Zhenhai , Zhang Tianyao , Li Weifeng , Rao Shun , Xiao Yang , Chen Yupeng , Zhang Yajun 
Published: June 2022

Abstract
Being one of the core power units of electric vehicles, the lithium-ion batteries (LIBs) are broadly concerned. However, in the cases of abuses, LIBs may counter thermal runaway, threatening the personal and property safety of users. In order to avoid the occurrence of thermal runaway, the battery thermal management system (BTMS) has been introduced to improve the safety, optimize the efficiency and prolong the service life of lithium-ion batteries. In this review, feasible thermal management schemes of LIBs system were summarized chronically, different thermal management schemes were evaluated, and case studies were made. The schemes of controlling the internal reaction control in the battery are highlighted as well. This review offers a comprehensive view of BTMS and proposes a promising future for the employment of lithium-ion batteries.
Indicators of Improvement in Performing Activities of Daily Living Among Older Patients Undergoing Rehabilitation Following Hip Fractures
Authors: Nishiomasu Koki , Ogawa Takahiro , Sato Keisuke 
Published: June 2022

This study aimed to evaluate the relationship between improvement in activities of daily living (ADL) and cognitive status during rehabilitation and assess factors associated with ADL improvement among older patients undergoing rehabilitation after hip fractures. This retrospective cohort study comprised 306 patients aged ≥80 years who underwent hip fracture rehabilitation. The functional independence measure gain during rehabilitation was significantly lower in the group with abnormal cognition than in the group with normal cognition. Mini-Mental State Examination, Charlson Comorbidity Index, daily duration of rehabilitation, and length of hospitalization for rehabilitation were independent factors associated with functional independence measure gain during rehabilitation in the multivariate regression analysis. Although older patients with cognitive impairment had lower ADL improvements during hip fracture rehabilitation, such patients may be able to improve their ADL by undergoing intensive and long rehabilitation programs. They should not refrain from such rehabilitation programs due to older age, fracture, and cognitive impairment.
Advanced chronic kidney disease among UK children
Authors: Plumb Lucy , Magadi Winnie , Casula Anna , Reynolds Ben C , Convery Mairead , Haq Shuman , Hegde Shivaram , Lunn Andrew , Malina Michal , Morgan Henry , Muorah Mordi , Tyerman Kay , Sinha Manish D , Wallace Dean , Inward Carol , Marks Stephen , Nitsch Dorothea , Medcalf James 
Published: June 2022

The UK Renal Registry currently collects information on UK children with kidney failure requiring long-term kidney replacement therapy (KRT), which supports disease surveillance and auditing of care and outcomes; however, data are limited on children with chronic kidney disease (CKD) not on KRT.MethodsIn March 2020, all UK Paediatric Nephrology centres submitted data on children aged <16 years with severely reduced kidney function as of December 2019, defined as an estimated glomerular filtration rate <30 mL/min/1.73 m2.ResultsIn total, 1031 children had severe CKD, the majority of whom (80.7%) were on KRT. The overall prevalence was 81.2 (95% CI 76.3 to 86.3) per million of the age-related population.ConclusionsThe prevalence of severe CKD among UK children is largely due to a high proportion of children on long-term KRT. Expanding data capture to include children with CKD before reaching failure will provide greater understanding of the CKD burden in childhood.
Transitions in health service use among women with poor mental health: a 7-year follow-up
Authors: Dolja-Gore Xenia , Loxton Deborah , D'Este Catherine , Byles Julie E 
Published: June 2022

ObjectiveWomen suffering from mental health problems require varied needs of mental health service utilisation. Transition between general practitioner and mental health services use are available through the Better Access Scheme initiative, for those in need of treatment. The study’s aim was to identify trajectories of mental health service utilisation by Australian women.DesignThe Australian Longitudinal Study on Women’s Health data linked to the administrative medical claims dataset were used to identify subgroups of women profiled by their mental health service use from 2006 to 2013. Latent growth mixture model is a statistical method to profile subgroups of individuals based on their responses to a set of observed variables allowing for changes over time. Latent class groups were identified, and used to examine predisposing factors associated with patterns of mental health service use change over time.SettingThis study was conducted in Australia.ParticipantsNational representative sample of women of born in 1973–1978, who were aged between 28 and 33 years at the start of our study period.ResultsSix latent class trajectories of women’s mental health service use were identified over the period 2006–2013. Approximately, one-quarter of the sample were classified as the most recent users, while approximate equal proportions were identified as either early users, late/low user or late-high users. Additional, subgroups were defined as the consistent-reduced user and the late-high users, over time. Only 7.2% of the sample was classified as consistent high users who potentially used the services each year.ConclusionThese findings suggest that use of the Better Access Scheme mental health services through primary care was varied over time and may be tailored to each individual’s needs for the treatment of depressive symptoms.
Increased risk of cardiovascular events and death in the initial phase after discontinuation of febuxostat or allopurinol: another story of the CARES trial
Authors: Ghang Byeong-zu , Lee Ji Sung , Choi Jihye , Kim Jinseok , Yoo Bin 
Published: June 2022

ObjectivesThe Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout (CARES) trial suggested a higher risk of cardiovascular (CV) death from febuxostat than from allopurinol. However, a significant number of patients died after discontinuation of febuxostat or allopurinol. We investigated whether major adverse cardiovascular events (MACE) and CV death were increased because of discontinuation of febuxostat or allopurinol using the CARES trial data.MethodsWe compared the MACE that occurred during administration and after discontinuation in the initial phase after discontinuation, and we compared the CV and non-CV mortality rates in the initial phase after discontinuation to determine the impact of discontinuation of febuxostat or allopurinol.ResultsAmong 6190 patients, the incidence rate per 100 person-years for MACE was 3.11 during administration and 6.71 after discontinuation. MACE was significantly increased after discontinuation compared with that during administration within 1 month (HR 7.40; 95% CI 5.38 to 10.17) and 6 months (HR 5.22; 95% CI 4.26 to 6.39). In the analysis excluding death induced by adverse events that occurred up to 1 day after the last medication, the CV mortality rate was higher than the non-CV mortality rate within 6 months (45.7% vs 27.9%, p=0.0001). In addition, changes in serum uric acid levels from baseline to the last measurement before discontinuation were significantly associated with higher MACE risk after drug discontinuation (HR 1.14; 95% CI 1.04 to 1.26).ConclusionsMACE and CV death were increased in the initial stage after discontinuation of febuxostat or allopurinol in patients with gout.
Low-dose CT hounsfield units: a reliable methodology for assessing vertebral bone density in radiographic axial spondyloarthritis
Authors: Marques Mary Lucy , Pereira da Silva Nuno , van der Heijde Desirée , Reijnierse Monique , Baraliakos Xenofon , Braun Juergen , van Gaalen Floris A , Ramiro Sofia 
Published: June 2022

ObjectiveStudying vertebral bone loss in radiographic axial spondyloarthritis (r-axSpA) has been challenging due to ectopic bone formation. We cross-sectionally analysed low-dose CT (ldCT) trabecular bone density Hounsfield units (HU) measurements and calculated inter-reader reliability at the vertebral level in patients with r-axSpA.MethodsLdCT scans of 50 patients with r-axSpA from the sensitive imaging in ankylosing spondylitis study, a multicentre 2-year prospective cohort were included. Trabecular bone HU taken from a region of interest at the centre of each vertebra (C3-L5) were independently assessed by two trained readers. HU mean (SD), and range were provided at the vertebral level, for each reader and centre separately. Inter-reader reliability and agreement were assessed using intraclass correlation coefficients (ICC; single measurements, absolute agreement, two-way mixed effects models); smallest detectable difference and Bland-Altman plots.ResultsOverall, 1100 vertebrae were assessed by each reader. HU values decreased from cranial to caudal vertebrae. For readers 1 and 2 respectively, the highest mean (SD) HU value was obtained at C3 (354(106) and 355(108)), and the lowest at L3 (153(65) and 150 (65)). Inter-reader reliability was excellent (ICC(2,1):0.89 to 1.00). SDD varied from 4 to 8. For most vertebrae, reader 1 scored somewhat higher than reader 2 (mean difference of scores ranging from −0.6 to 2.9 HU). Bland-Altman plots showed homoscedasticity.ConclusionLdCT measurement of HU is a feasible method to assess vertebral bone density in r-axSpA with excellent inter-reader reliability from C3 to L5. These results warrant further validation and longitudinal assessment of reliability.
Clinical and laboratory aspects of condylomata lata lesions of syphilis
Authors: Towns Janet M , Denham Ian , Chow Eric P F , Graves Stephen , Fairley Christopher K , Williamson Deborah , Azzato Francesca , Chen Marcus Y 
Published: June 2022

ObjectivesCondylomata lata are a less common but distinctive syphilitic lesion. Variable theories as to their nature and origin exist. The aim of this study was to determine the clinical and laboratory characteristics of condylomata lata by determining (1): the most closely aligned stage of syphilis, based on the rapid plasma reagin (RPR) titre; (2) symptom duration and (3) Treponema pallidum PCR cycle threshold (CT) values, as an indicator of organism load.MethodsThis was a retrospective study of patients with T. pallidum PCR-positive condylomata lata lesions, attending a clinic in Melbourne, Australia, between 2011 and 2021. Syphilis serology was undertaken and RPR titres compared between condylomata lata, primary and secondary syphilis cases.Results51 cases with T. pallidum PCR-positive condylomata lata were included. 41 cases were in men, 40 of whom were men who have sex with men (MSM), and 10 in women. Twelve of 51 (24%) cases were in HIV-positive MSM. Thirty-three of 51 (65%) had other mucocutaneous signs of secondary syphilis; 18 (35%) had no other signs of secondary syphilis. The median RPR titre among the 51 condylomata lata cases was 1:128, compared with the median RPR titre of primary syphilis (1:4) and of secondary syphilis (1:128). The median duration of lesions was 24 (IQR 10–60) days, with no significant difference between those with and without other signs of secondary syphilis (p=0.75). Median CT values for condylomata lata (CT=31) and primary syphilis (CT=31) were significantly lower than for other secondary syphilis lesion types (CT=33), indicating higher T. pallidum loads for condylomata lata and primary lesions compared with other secondary syphilis lesion types.DiscussionThese findings support condylomata lata as lesions that occur during the secondary stage of syphilis and which are likely to be highly infectious.
Superintegrability in $$\beta $$-deformed Gaussian Hermitian matrix model from W-operators
Authors: Mishnyakov V. , Oreshina A. 
Published: June 2022

AbstractThis paper is devoted to the phenomenon of superintegrability. This phenomenon is manifested in the existence of a formula for character averages, expressed through the same characters at special points and of its various generalization. In this paper we develop a method of proving such formulas from first principle from Virasoro constraints and W-representation. We apply it to prove the formula for the Jack functions averages – appropriate analogue of characters for the $$\beta $$
β
-deformed Hermitian Gaussian matrix model. We also sketch the construction of W-operators from Calogero–Ruijsenaars Hamiltonians.
Approximate counting and NP search problems
Authors: Kołodziejczyk Leszek Aleksander , Thapen Neil 
Published: June 2022

We study a new class of NP search problems, those which can be proved total using standard combinatorial reasoning based on approximate counting. Our model for this kind of reasoning is the bounded arithmetic theory [Formula: see text] of [E. Jeřábek, Approximate counting by hashing in bounded arithmetic, J. Symb. Log. 74(3) (2009) 829–860]. In particular, the Ramsey and weak pigeonhole search problems lie in the new class. We give a purely computational characterization of this class and show that, relative to an oracle, it does not contain the problem CPLS, a strengthening of PLS. As CPLS is provably total in the theory [Formula: see text], this shows that [Formula: see text] does not prove every [Formula: see text] sentence which is provable in bounded arithmetic. This answers the question posed in [S. Buss, L. A. Kołodziejczyk and N. Thapen, Fragments of approximate counting, J. Symb. Log. 79(2) (2014) 496–525] and represents some progress in the program of separating the levels of the bounded arithmetic hierarchy by low-complexity sentences. Our main technical tool is an extension of the “fixing lemma” from [P. Pudlák and N. Thapen, Random resolution refutations, Comput. Complexity, 28(2) (2019) 185–239], a form of switching lemma, which we use to show that a random partial oracle from a certain distribution will, with high probability, determine an entire computation of a [Formula: see text] oracle machine. The introduction to the paper is intended to make the statements and context of the results accessible to someone unfamiliar with NP search problems or with bounded arithmetic.