bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatially averaged stratigraphic data to inform watershed sediment routing: An example from the Mid-Atlantic United States
Authors: Pizzuto J.E. , Skalak K.J. , Benthem A. , Mahan S.A. , Sherif M. , Pearson A.J. 
Published: May 2022

AbstractNew and previously published stratigraphic data define Holocene to present sediment storage time scales for Mid-Atlantic river corridors. Empirical distributions of deposit ages and thicknesses were randomly sampled to create synthetic age-depth records. Deposits predating European settlement accumulated at a (median) rate of 0.06 cm yr–1, range from ∼18,000 to 225 yr old, and represent 39% (median) of the total accumulation. Sediments deposited from 1750 to 1950 (“legacy sediments”) accumulated at a (median) rate of 0.39 cm yr–1 and comprise 47% (median) of the total, while “modern sediments” (1950–present) represent 11% of the total and accumulated at a (median) rate of 0.25 cm yr–1. Synthetic stratigraphic sequences, recast as age distributions for the presettlement period, in 1900 A.D., and at present, reflect rapid postsettlement alluviation, with enhanced preservation of younger sediments related to postsettlement watershed disturbance. An averaged present age distribution for vertically accreted sediment has modal, median, and mean ages of 190, 230, and 630 yr, reflecting the predominance of stored legacy sediments and the influence of relatively few, much older early Holocene deposits. The present age distribution, if represented by an exponential approximation (mean age ∼300 yr), and naively assumed to represent steady-state conditions, implies median sediment travel times on the order of centuries for travel distances greater than ∼100 km. The percentage of sediment reaching the watershed outlet in 30 yr (a reasonable time horizon to achieve watershed restoration efficacy) is ∼60% for a distance of 50 km, but this decreases to &lt;20% for distances greater than 200 km. Age distributions, evaluated through time, not only encapsulate the history of sediment storage, but they also provide data for calibrating watershed-scale sediment-routing models over geological time scales.
The role of screening and surveillance in the detection of childhood vision impairment and blindness in the UK
Authors: Solebo Ameenat Lola , Teoh Lucinda , Rahi Jugnoo Sangeeta 
Published: May 2022

ObjectiveUnderstanding pathways to detection for childhood visual impairment (VI) is critical for planning services. We aimed to describe patterns of detection for childhood VI.Design and settingCross-sectional study using data from British Childhood Visual Impairment and Blindness Study 2.PatientsChildren newly diagnosed with VI, severe vision impairment or blindness (SVI/BL)—that is, visual acuity worse than logMAR 0.5 in both eyes—were identified through active surveillance, with data collection at diagnosis and 1 year later.Outcome measureMethod of detection of vision/eyes problem.Results784 children (45%, 356 girls) were identified, of whom 313 (40%) had VI, 471 (60%) had SVI/BL. Additional non-ophthalmic disorders or impairments (VI/SVI/BL ‘plus’), were diagnosed in 72% (559/784). Of the 784, 173 children were detected through routine screening (22%), 248 through targeted examinations (32%) and 280 through family self-referral (36%). Parents and carers had only reported symptoms in 55% of children who manifested them, with evidence that families living in socioeconomically deprived areas were less likely to report concerns. Paediatricians were the professionals most likely to raise initial suspicion of visual disability.ConclusionsOur findings show that targeted screening and surveillance is important for the detection of full spectrum childhood visual impairment (VI/SVI/BL), as a significant proportion of children will not have symptoms, or their parents or carers will not report symptoms. As paediatricians were the professionals most commonly involved in detection, it would be helpful if their core competencies included the skills needed to undertake simple assessments of vision.
Specific location of ocular adnexal lymphoma and mortality: an international multicentre retrospective study
Authors: Vest Stine Dahl , Coupland Sarah E. , Esmaeli Bita , Finger Paul T. , Graue Gerardo F. , Grossniklaus Hans E. , Hindso Tine Gadegaard , Holm Frederik , Honavar Santosh G. , Khong Jwu Jin , Kirkegaard Marina Knudsen , McKelvie Penelope A. , Mikkelsen Lauge Hjorth , Mulay Kaustubh , Rasmussen Peter Kristian , Siersma Volkert , Sjö Lene Dissing , Sniegowski Matthew C. , Thuro Bradley A. , Vemuganti Geeta K. , Heegaard Steffen 
Published: May 2022

AimsTo examine whether the specific location of ocular adnexal lymphoma (OAL) and the American Joint Committee on Cancer (AJCC) TNM tumour stage are prognostic factors for mortality in the main OAL subtypes.MethodsClinical and survival data were retrospectively collected from seven international eye cancer centres. All patients from 1980 to 2017 with histologically verified primary or secondary OAL were included. Cox regression was used to compare the ocular adnexal tumour locations on all-cause mortality and disease-specific mortality.ResultsOAL was identified in 1168 patients. The most frequent lymphoma subtypes were extranodal marginal zone B-cell lymphoma (EMZL) (n=688, 59%); follicular lymphoma (FL) (n=150, 13%); diffuse large B-cell lymphoma (DLBCL) (n=131, 11%); and mantle cell lymphoma (MCL) (n=89, 8%). AJCC/TNM tumour-stage (T-stage) was significantly associated with disease-specific mortality in primary ocular adnexal EMZL and increased through T-categories from T1 to T3 disease. No associations between AJCC/TNM T-stage and mortality were found in primary ocular adnexal FL, DLBCL, or MCL. EMZL located in the eyelid had a significantly increased disease-specific mortality compared with orbital and conjunctival EMZL, in both primary EMZL and the full EMZL cohort. In DLBCL, eyelid location had a significantly higher disease-specific mortality compared with an orbital or lacrimal gland location.ConclusionDisease-specific mortality is associated with AJCC/TNM T-stage in primary ocular adnexal EMZL patients. Lymphoma of the eyelid has the highest disease-specific mortality in primary EMZL, and in the full cohort of EMZL and DLBCL patients.
Variation in revascularisation use and outcomes of patients in hospital with acute myocardial infarction across six high income countries: cross sectional cohort study
Authors: Cram Peter , Hatfield Laura A , Bakx Pieter , Banerjee Amitava , Fu Christina , Gordon Michal , Heine Renaud , Huang Nicole , Ko Dennis , Lix Lisa M , Novack Victor , Pasea Laura , Qiu Feng , Stukel Therese A , de Groot Carin Uyl , Yan Lin , Landon Bruce 
Published: May 2022

AbstractObjectivesTo compare treatment and outcomes for patients admitted to hospital with a primary diagnosis of ST elevation or non-ST elevation myocardial infarction (STEMI or NSTEMI) in six high income countries with very different healthcare delivery systems.DesignRetrospective cross sectional cohort study.SettingPatient level administrative data from the United States, Canada (Ontario and Manitoba), England, the Netherlands, Israel, and Taiwan.ParticipantsAdults aged 66 years and older admitted to hospital with STEMI or NSTEMI between 1 January 2011 and 31 December 2017.Outcomes measuresThe three categories of outcomes were coronary revascularisation (percutaneous coronary intervention or coronary artery bypass graft surgery), mortality, and efficiency (hospital length of stay and 30 day readmission). Rates were standardised to the age and sex distribution of the US acute myocardial infarction population in 2017. Outcomes were assessed separately for STEMI and NSTEMI. Performance was evaluated longitudinally (over time) and cross sectionally (between countries).ResultsThe total number of hospital admissions ranged from 19 043 in Israel to 1 064 099 in the US. Large differences were found between countries for all outcomes. For example, the proportion of patients admitted to hospital with STEMI who received percutaneous coronary intervention in hospital during 2017 ranged from 36.9% (England) to 78.6% (Canada; 71.8% in the US); use of percutaneous coronary intervention for STEMI increased in all countries between 2011 and 2017, with particularly large rises in Israel (48.4-65.9%) and Taiwan (49.4-70.2%). The proportion of patients with NSTEMI who underwent coronary artery bypass graft surgery within 90 days of admission during 2017 was lowest in the Netherlands (3.5%) and highest in the US (11.7%). Death within one year of admission for STEMI in 2017 ranged from 18.9% (Netherlands) to 27.8% (US) and 32.3% (Taiwan). Mean hospital length of stay in 2017 for STEMI was lowest in the Netherlands and the US (5.0 and 5.1 days) and highest in Taiwan (8.5 days); 30 day readmission for STEMI was lowest in Taiwan (11.7%) and the US (12.2%) and highest in England (23.1%).ConclusionsIn an analysis of myocardial infarction in six high income countries, all countries had areas of high performance, but no country excelled in all three domains. Our findings suggest that countries could learn from each other by using international comparisons of patient level nationally representative data.
Right ventricular remodelling in pulmonary arterial hypertension predicts treatment response
Authors: Goh Ze Ming , Balasubramanian Nithin , Alabed Samer , Dwivedi Krit , Shahin Yousef , Rothman Alexander M K , Garg Pankaj , Lawrie Allan , Capener David , Thompson A A Roger , Alandejani Faisal , Wild Jim M , Johns Christopher S , Lewis Robert A , Gosling Rebecca , Sharkey Michael , Condliffe Robin , Kiely David G , Swift Andrew J 
Published: May 2022

ObjectivesTo determine the prognostic value of patterns of right ventricular adaptation in patients with pulmonary arterial hypertension (PAH), assessed using cardiac magnetic resonance (CMR) imaging at baseline and follow-up.MethodsPatients attending the Sheffield Pulmonary Vascular Disease Unit with suspected pulmonary hypertension were recruited into the ASPIRE (Assessing the Spectrum of Pulmonary hypertension Identified at a REferral Centre) Registry. With exclusion of congenital heart disease, consecutive patients with PAH were followed up until the date of census or death. Right ventricular end-systolic volume index adjusted for age and sex and ventricular mass index were used to categorise patients into four different volume/mass groups: low-volume-low-mass, low-volume-high-mass, high-volume-low-mass and high-volume-high-mass. The prognostic value of the groups was assessed with one-way analysis of variance and Kaplan-Meier plots. Transition of the groups was studied.ResultsA total of 505 patients with PAH were identified, 239 (47.3%) of whom have died at follow-up (median 4.85 years, IQR 4.05). The mean age of the patients was 59±16 and 161 (32.7%) were male. Low-volume-low-mass was associated with CMR and right heart catheterisation metrics predictive of improved prognosis. There were 124 patients who underwent follow-up CMR (median 1.11 years, IQR 0.78). At both baseline and follow-up, the high-volume-low-mass group had worse prognosis than the low-volume-low-mass group (p<0.001). With PAH therapy, 73.5% of low-volume-low-mass patients remained in this group, whereas only 17.4% of high-volume-low-mass patients transitioned into low-volume-low-mass.ConclusionsRight ventricular adaptation assessed using CMR has prognostic value in patients with PAH. Patients with maladaptive remodelling (high-volume-low-mass) are at high risk of treatment failure.
Examining the protective effects of social capital and social support on the perpetration of violence among a national sample of adolescents
Authors: Schober Daniel J. 
Published: May 2022

IntroductionMillions of children witness violence and are victims of violence each year. Previous research suggests that this is a risk factor for perpetrating violence. There is a paucity of studies that examine factors that protect violence-exposed youth from perpetrating violence.MethodsThis study used a panel design to measure the effects of exposure to violence on the perpetration of violence. It examined the protective effects of social support and school social capital on the risk of exposure to violence, using multivariate logistic regression modelling. The sample was weighted to reflect a national population.ResultsThe median age of the sample was 15. When considering risk factors only, those who ‘saw someone shoot or stab another person’ were at 4.77 times (95% CI 3.19 to 7.13) greater risk for perpetrating interpersonal violence. In the full model (risk and protective factors, (N=8375)), those with lower school social capital were at 2.43 (95% CI 1.15 to 5.15) to 2.91 (95% CI 1.02 to 8.29) times greater risk of perpetrating violence compared with those with the highest school social capital; adding the protective factors into the model reduced the odds of perpetrating violence from 4.77 times to 3.47 times (95% CI 1.97 to 6.11) (p<0.001).ConclusionOn a national level, the protective effects of school social capital could translate to a substantial reduction of violence. School-wide policies and programmes that reach all adolescents in a school and promote social capital should be pursued as a strategy to prevent the perpetration of interpersonal violence.
One-third of patients with lupus nephritis classified as complete responders continue to accrue progressive renal damage despite resolution of proteinuria
Authors: Weeding Emma , Fava Andrea , Magder Laurence , Goldman Daniel , Petri Michelle 
Published: May 2022

ObjectiveTreatment response in lupus nephritis (LN) is defined based on proteinuria, yet protocol kidney biopsy studies have shown that patients with lupus can have active nephritis in the absence of proteinuria. Using estimated glomerular filtration rate (eGFR) trajectories, we characterised early chronic kidney disease in LN and examined whether certain patients continue to accrue renal damage despite proteinuric response.MethodsWe conducted a single-centre study of patients diagnosed with their first episode of biopsy-proven class III, IV, and/or V LN (n=37). For each patient, eGFR trajectory was graphed over 5 years following renal biopsy. Participants were divided into those with progressive eGFR loss (eGFR slope <−5 mL/min/1.73 m2/year) versus those with stable eGFR. Participant demographics, renal biopsy features and response status at 1 year (urine protein to creatinine ratio <500 mg/g) were compared between eGFR trajectory groups.ResultsOverall, 30% (n=11) of participants accrued progressive eGFR loss despite standard of care therapy over the first 5 years following renal biopsy. There were no significant differences in baseline renal biopsy features, medication regimens or comorbidities between eGFR trajectory groups. Resolution of proteinuria at 1 year did not differentiate between groups: 6 of 18 (33%) of complete responders continued to accrue renal damage compared with 5 of 17 (29%) of non-responders. Response status could not be assigned for two participants in the stable eGFR group due to missing clinical information at 1 year.ConclusionsWe identified an understudied category of patients with LN who accrue progressive renal damage despite apparent response to standard of care therapy. Better definitions and biomarkers of response are needed to improve renal outcomes and trial design.
Weekend versus weekday hospitalization and clinical outcomes in atrial fibrillation patients with and without stroke
Authors: Hu Wei Syun , Lin Cheng-Li 
Published: May 2022

Abstract

Purpose
The relation between hospitalization timing and risk of clinical outcomes among patients with atrial fibrillation (AF) with and without stroke remained undetermined.

Methods
Rehospitalization due to AF, cardiovascular (CV) death and all-cause mortality were the outcomes of interest in this study. Multivariable Cox proportional hazard model was applied to estimate the adjusted hazard ratio (HR) and 95% confidence interval (CI).

Results
While considering patients with AF hospitalized during weekdays without stroke as the reference group, patients with AF hospitalized during weekends with stroke had the risk of AF rehospitalization, CV death and all-cause death by 1.48 (95% CI 1.44 to 1.51), 1.77 (95% CI 1.71 to 1.83) and 1.17 (95% CI 1.15 to 1.19) times, respectively.

Conclusion
Patients with AF hospitalized during weekends with stroke had the worst clinical outcomes.
Blue phosphorescent platinum(IV) complex bearing bipyridine ligand for potential application in organic light-emitting diodes (OLEDs)
Authors: Kang Jisu , Moon Suk-Hee , Paek Sanghyun , Kang Youngjin 
Published: May 2022

A cyclometalated Pt(IV) compound, Pt(dfpypy)2(Me)Cl (1), with blue phosphorescence was prepared using 2′,6′-difluoro-2,3′-bipyridine (dfpypy) as a C^N chelate ligand. Compound 1 exhibits distorted octahedral geometries around the platinum ion and has strong intermolecular interactions via interatomic contacts (H···N/F/Cl) involving hydrogen bond interactions based on Hirshfeld surface analysis. This compound shows bright blue phosphorescence emissions with λmax = 427 and 455 nm and a high photoluminescence quantum efficiency (ΦPL = 0.60). Furthermore, a good blue colour purity with Commission Internationale de L'Eclairage (1931) coordinates ( x, y) of (0.14, 0.17) was observed in the thin film, which was close to pure blue. TD-DFT calculations revealed that the electronic transition can be attributed to a combination of intraligand charge transfer (πbpy–π*bpy) and ligand-to-ligand charge transfer [pz(Cl)–π*(dfpypy)] with a small contribution from metal-to-ligand charge transfer (Ptd−π*bpy). Owing to the introduction of the electronegative C^N chelate dfpypy, the emission of compound 1 was blueshifted by 20 nm compared with its analog [Pt(ppy)2(Me)Cl] ( λmax = 447), where ppy is 2-phenylpyridine.
Paraclostridium benzoelyticum Bacterium-Mediated Zinc Oxide Nanoparticles and Their In Vivo Multiple Biological Applications
Authors: Faisal Shah , Abdullah  , Rizwan Muhammad , Ullah Riaz , Alotaibi Amal , Khattak Aishma , Bibi Nadia , Idrees Muhammad 
Published: May 2022

We presented a low-cost, eco-friendly, and efficient bacterium-mediated synthesis of zinc oxide nanoparticles (ZnO-NPs) utilizing Paraclostridium benzoelyticum strain 5610 as a capping and reducing agent. Scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, energy-dispersive X-ray, and UV-vis spectroscopy were used to physiochemically characterize the biosynthesized ZnO-NPs. A major narrow peak at 441 nm was observed using UV-visible spectroscopy, verifying the presence of nanoparticles. According to SEM and TEM studies, the average dimensions of ZnO-NPs was 50 nm. The crystal size of 48.22 nm was determined by XRD analysis. FTIR analysis confirmed the presence of various reducing metabolites on the surface of ZnO-NPs. The synthesized nanoparticles were investigated for biological activity against Helicobacter suis, Helicobacter bizzozeronii, Helicobacter felis, and Helicobacter salomonis. Helicobacter suis was the most vulnerable strain, with an inhibitory zone of

19.53
±
0.62

mm at 5 mg/mL dosage. The anti-inflammatory and the findings of the rat paw edema experiments revealed that the bacterium-mediated ZnO-NPs had a strong inhibitory action. In the arthritis model, the solution of ZnO-NPs showed

87.62
±
0.12

% inhibitory effect of edema after 21 days when linked with that of the standard drug. In the antidiabetic assay, ZnO-NPs sharply reduced glucose level in STZ-induced diabetic mice. In this study, the particle biocompatibility by human red blood cells was also determined. Keeping in view the biological importance of ZnO-NPs, we may readily get the conclusion that Paraclostridium benzoelyticum strain 5610-mediated ZnO-NPs will be a prospective antidiabetic, antibacterial, antiarthritic, and anti-inflammatory agent in vivo experimental models and can be used as a potent antidiabetic drug.
Retrieve Fast, Rerank Smart: Cooperative and Joint Approaches for Improved Cross-Modal Retrieval
Authors: Geigle Gregor , Pfeiffer Jonas , Reimers Nils , Vulić Ivan , Gurevych Iryna 
Published: May 2022

Abstract
Current state-of-the-art approaches to cross- modal retrieval process text and visual input jointly, relying on Transformer-based architectures with cross-attention mechanisms that attend over all words and objects in an image. While offering unmatched retrieval performance, such models: 1) are typically pretrained from scratch and thus less scalable, 2) suffer from huge retrieval latency and inefficiency issues, which makes them impractical in realistic applications. To address these crucial gaps towards both improved and efficient cross- modal retrieval, we propose a novel fine-tuning framework that turns any pretrained text-image multi-modal model into an efficient retrieval model. The framework is based on a cooperative retrieve-and-rerank approach that combines: 1) twin networks (i.e., a bi-encoder) to separately encode all items of a corpus, enabling efficient initial retrieval, and 2) a cross-encoder component for a more nuanced (i.e., smarter) ranking of the retrieved small set of items. We also propose to jointly fine- tune the two components with shared weights, yielding a more parameter-efficient model. Our experiments on a series of standard cross-modal retrieval benchmarks in monolingual, multilingual, and zero-shot setups, demonstrate improved accuracy and huge efficiency benefits over the state-of-the-art cross- encoders.1
♫ MuSiQue: Multihop Questions via Single-hop Question Composition
Authors: Trivedi Harsh , Balasubramanian Niranjan , Khot Tushar , Sabharwal Ashish 
Published: May 2022

Abstract
Multihop reasoning remains an elusive goal as existing multihop benchmarks are known to be largely solvable via shortcuts. Can we create a question answering (QA) dataset that, by construction, requires proper multihop reasoning? To this end, we introduce a bottom–up approach that systematically selects composable pairs of single-hop questions that are connected, that is, where one reasoning step critically relies on information from another. This bottom–up methodology lets us explore a vast space of questions and add stringent filters as well as other mechanisms targeting connected reasoning. It provides fine-grained control over the construction process and the properties of the resulting k-hop questions. We use this methodology to create MuSiQue-Ans, a new multihop QA dataset with 25K 2–4 hop questions. Relative to existing datasets, MuSiQue-Ans is more difficult overall (3× increase in human–machine gap), and harder to cheat via disconnected reasoning (e.g., a single-hop model has a 30-point drop in F1). We further add unanswerable contrast questions to produce a more stringent dataset, MuSiQue-Full. We hope our datasets will help the NLP community develop models that perform genuine multihop reasoning.1
Relational Memory-Augmented Language Models
Authors: Liu Qi , Yogatama Dani , Blunsom Phil 
Published: May 2022

Abstract
We present a memory-augmented approach to condition an autoregressive language model on a knowledge graph. We represent the graph as a collection of relation triples and retrieve relevant relations for a given context to improve text generation. Experiments on WikiText-103, WMT19, and enwik8 English datasets demonstrate that our approach produces a better language model in terms of perplexity and bits per character. We also show that relational memory improves coherence, is complementary to token-based memory, and enables causal interventions. Our model provides a simple yet effective way to combine an autoregressive language model and a knowledge graph for more coherent and logical generation.