bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical research capability enhanced for medical undergraduates: an innovative simulation-based clinical research curriculum development
Authors: Yan Siyu , Huang Qiao , Huang Jiao , Wang Yu , Li Xuhui , Wang Yongbo , Luo Lisha , Wang Yunyun , Guo Yi , Zeng Xiantao , Jin Yinghui 
Published: July 2022

AbstractBackgroundClinical research has frequently not been taught in a practical way, often resulting in a very didactic approach rendering it not very accessible for medical undergraduates. Simulation can provide an immersive, interactive, and reflective experience and may be applied to the clinical research curriculum.MethodsA 7-step model, modified from Kern’s six-step approach and Khamis’s stepwise model, was used to develop the curriculum. A questionnaire survey on undergraduates’ attitude towards, knowledge and practice of clinical research and simulation education was conducted to generate a targeted needs assessment. The simulation framework was integrated into the development of educational strategies. Experts were consulted to assess the curriculum prior to implementation.ResultsTalent construction in China needs an innovative capability-enhanced clinical research curriculum. Sixty-six clinical undergraduates in our school completed the survey. 89.39% (59/66) of them hadn’t participated in clinical research, while 93.94% (62/66) would like to conduct clinical trials if possible. 75.76% of respondents didn’t have knowledge of or practical abilities in clinical trials. The mean score for practical ability (2.02 ± 0.92) was lower than that of knowledge (2.20 ± 0.93) (P < 0.01). The dimension of case report form got the lowest score among the five dimensions. Participating in clinical research (P = 0.04) and learning for themselves (P < 0.01) by a few students may have increased the total score. The curriculum was designed to simulate the whole process from protocol writing, registration, ethical approval, implementation, and data analysis to reporting based on one case study, and was divided into two parts to simulate different types of research: randomized controlled trials and observational studies. It was conducted in semesters 5 and 7 respectively, both including 16 sessions. After expert consultation, one session having a 29.01% coefficient of variation was adjusted and replaced. The final simulation class design scenario scripts are provided for reference.ConclusionsThe targeted needs assessment exposed medical undergraduates’ poor knowledge of and abilities in clinical research. This is the first report of a simulation-based clinical research curriculum developed in China, and adds curriculum development and design details to the limited related published studies.
Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
Authors: Zhao Hui , Ming Tianqi , Tang Shun , Ren Shan , Yang Han , Liu Maolun , Tao Qiu , Xu Haibo 
Published: July 2022

AbstractBackgroundThe Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic development and cancer, but is also involved in normal physiological processes in adults. The canonical Wnt signaling pathway regulates cell pluripotency and determines the differentiation fate of cells during development. The canonical Wnt signaling pathway (also known as the Wnt/β-catenin signaling pathway) is a recognized driver of colon cancer and one of the most representative signaling pathways. As a functional effector molecule of Wnt signaling, the modification and degradation of β-catenin are key events in the Wnt signaling pathway and the development and progression of colon cancer. Therefore, the Wnt signaling pathway plays an important role in the pathogenesis of diseases, especially the pathogenesis of colorectal cancer (CRC).ObjectiveInhibit the Wnt signaling pathway to explore the therapeutic targets of colorectal cancer.MethodsBased on studying the Wnt pathway, master the biochemical processes related to the Wnt pathway, and analyze the relevant targets when drugs or inhibitors act on the Wnt pathway, to clarify the medication ideas of drugs or inhibitors for the treatment of diseases, especially colorectal cancer.ResultsWnt signaling pathways include: Wnt/β-catenin or canonical Wnt signaling pathway, planar cell polarity (Wnt-PCP) pathway and Wnt-Ca2+signaling pathway. The Wnt signaling pathway is closely related to cancer cell proliferation, stemness, apoptosis, autophagy, metabolism, inflammation and immunization, microenvironment, resistance, ion channel, heterogeneity, EMT/migration/invasion/metastasis. Drugs/phytochemicals and molecular preparations for the Wnt pathway of CRC treatment have now been developed. Wnt inhibitors are also commonly used clinically for the treatment of CRC.ConclusionThe development of drugs/phytochemicals and molecular inhibitors targeting the Wnt pathway can effectively treat colorectal cancer clinically.
Prognostic prediction of systemic immune-inflammation status for patients with colorectal cancer: a novel pyroptosis-related model
Authors: Hu Jun , Tian Caijuan , Zhao Yanpeng , Guo Yixian , Chen Shuo 
Published: July 2022

AbstractPyroptosis and related gasdermin family proteins play an important role in the tumorigenesis of colorectal cancer (CRC). However, the prognostic roles of pyroptosis-related genes (PRGs) and their relation to infiltrates of immune cells in the pathogenesis of CRC remain unclear. Using this study, we set up a prognostic gene pattern on the basis of 13 PRGs (AIM2, CASP1, CASP5, CASP6, CASP8, CASP9, ELANE, GPX4, GSDMD, NLRP7, NOD2, PJVK, and PRKACA) for CRC patients. A comprehensive bioinformatics analysis based on these genes was then performed. With the good AUC prediction value of the ROC curves, the group with high hazard first had a poorer survival prognosis than the group with low hazard. Second, we found that PRGs were significantly related to inflammation-associated genes and immune-associated genes in CRC. Then, we identified a correlation of PRGs with immune infiltrations in CRC. For instance, the abundances of resting NK cells resting and neutrophils were higher in the low hazard group than in the high hazard group. Overall, this work indicated that PRGs contributed to generate heterogeneity of the tumor microenvironment (TME) in CRC. This prognostic PRG model may provide a starting point for the early diagnosis and medication use of CRC.
Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents
Authors: Huang Mengqi , Lv Qian , Xie Jingyan 
Published: July 2022

AbstractBilateral ovarian epithelial neoplasms in adolescents are rare. Moreover, borderline mucinous neoplasms with local intraepithelial carcinoma with anaplastic carcinoma are even more infrequent. Herein, we presented a single case (a 17-year-old female) with regular menstrual cycles and stomach pain when eating who was diagnosed with a left ovarian tumor accompanied by mural nodules. The right ovarian cyst, the left ovary, and the fallopian tube were removed by surgery. Intraoperative diagnosis suggested a bilateral ovarian tumor with mural nodules, which include three different pathological types: sarcomatoid transformation, anaplastic carcinoma, and sarcoma. Paclitaxel combined with carboplatin was given for 6 cycles after an operation, and gonadotropin-releasing hormone agonist (GnRHa) was given at the beginning of chemotherapy for 3 cycles for ovarian function protection. Regular follow-up (the last follow-up was performed 48 months after the operation) of gynecological ultrasound and tumor indicators did not indicate recurrence. In clinical practice, it is necessary to pay attention to the symptoms such as abdominal pain in adolescent females. Routine non-invasive pelvic ultrasound is recommended to fully evaluate the nature of the tumor before surgery, and decide the operation mode. Also, intraoperative frozen pathology of the tissue should be performed as soon as possible.
Understanding the dog population in the Republic of Ireland: insight from existing data sources?
Authors: More Simon J. , Collins Daniel M. , Meunier Natascha V. , Messam Locksley L. McV. , Doyle Rob , Maguire Aiden , Murray Sean , Reilly Patricia , Lawler Catherine 
Published: July 2022

Abstract
Background
Reliable information about national pet dog populations is an important contributor to informed decision-making, both by governments and national dog welfare organisations. In some countries, there is an improved understanding of aspects of the national pet dog population, but as yet limited published information is available in Ireland. The current study reviews the utility of existing data to inform our understanding of recent changes to the pet dog population in Ireland, including both biological and organisational processes.

Results
Based on national data on dog licencing and microchipping registration, pet dog numbers have remained relatively stable in recent years (ie prior to the COVID-19 pandemic). Since 2015, there has been a substantial decrease in the number of dogs managed through dog control centres. Although the completeness of the data are likely variable, there appears to be substantial, and increasing, number of dogs moving from Ireland to other countries, including UK, Sweden, Italy, Germany and Singapore. We also note an increase (albeit much smaller) in the number of dogs being moved into Ireland.

Conclusions
This study highlights the challenges faced when using existing national data to gain insights into the dog population of Ireland. The linking of existing national databases (individual dog identification, dog licencing, dog control statistics) has the potential to improve both the representativeness and accuracy of information about the Irish pet dog population. In the next phases of our work, we will focus on the work of dog welfare organisations, given both the increased role played by these organisations and the substantial public funding that has been committed in this sector.
Optimization algorithm for feedback and feedforward policies towards robot control robust to sensing failures
Authors: Kobayashi Taisuke , Yoshizawa Kenta 
Published: July 2022

Abstract
Background and problem statement
Model-free or learning-based control, in particular, reinforcement learning (RL), is expected to be applied for complex robotic tasks. Traditional RL requires that a policy to be optimized is state-dependent, that means, the policy is a kind of feedback (FB) controllers. Due to the necessity of correct state observation in such a FB controller, it is sensitive to sensing failures. To alleviate this drawback of the FB controllers, feedback error learning integrates one of them with a feedforward (FF) controller. RL can be improved by dealing with the FB/FF policies, but to the best of our knowledge, a methodology for learning them in a unified manner has not been developed.

Contribution
In this paper, we propose a new optimization problem for optimizing both the FB/FF policies simultaneously. Inspired by control as inference, the proposed optimization problem considers minimization/maximization of divergences between trajectories, one is predicted by the composed policy and a stochastic dynamics model, and others are inferred as optimal/non-optimal ones. By approximating the stochastic dynamics model using variational method, we naturally derive a regularization between the FB/FF policies. In numerical simulations and a robot experiment, we verified that the proposed method can stably optimize the composed policy even with the different learning law from the traditional RL. In addition, we demonstrated that the FF policy is robust to the sensing failures and can hold the optimal motion.
Assessment of salivary alpha amylase and mucin-4 before and after non-surgical treatment of peri-implant mucositis
Authors: Aldulaijan Hajer A. , Al-Zawawi Abeer S. , Shaheen Marwa Y. , Ali Dena , Divakar Darshan Devang , Basudan Amani M. 
Published: July 2022

Abstract
Background
The present study was based on the null hypothesis that there is no difference in clinicoradiographic parameters and whole salivary alpha amylase (AA) and mucin-4 levels before and after non-surgical mechanical debridement (NSMD) of patients with peri-implant mucositis (PM). The aim was to assess whole salivary AA and mucin-4 levels before and after treatment of PM.

Methods
Patients with PM (Group-1) and individuals without peri-implant diseases (Group-2) were included. Demographic data was collected and peri-implant modified plaque and bleeding indices (mPI and mBI, respectively), probing depth (PD) and crestal bone loss were measured at baseline. Levels of AA and mucin-4 were assessed in unstimulated whole saliva samples. All patients underwent full-mouth non-surgical periodontal therapy (NSPT) and NSMD; and clinical parameters and salivary biomarkers were re-assessed after 3 months. Level of significance was set at P < 0.01.

Results
Twenty-six and 32 individuals were included in groups 1 and 2, respectively. None of the participants had periodontitis. At baseline clinical periodontal parameters (PI [P < 0.001], GI [P < 0.001], clinical AL [P < 0.001] and PD [P < 0.001]) were significantly high in Group-1 than Group-2. At 3-month follow-up, there was a statistically significant reduction in clinical periodontal and peri-implant parameters (PI [P < 0.01], GI [P < 0.01], and PD [P < 0.01]) in Group-1 compared with their baseline values. At baseline, salivary AA levels were significantly high in Group-1 than Group-2 (P < 0.01). At 3-month follow-up, there was no significant difference in whole salivary AA levels among patients in groups 1 and 2.

Conclusions
The AA and mucin-4 levels are potential biomarkers for evaluation of peri-implant diseases including PM. Mechanical instrumentation continues to be the most predictable treatment option for the management of peri-implant diseases.
Does union type make a difference when you separate? Frequency of father–child contact and father’s satisfaction with the relation
Authors: Zilincikova Zuzana , Albertini Marco 
Published: July 2022

AbstractGrowing separation and divorce rates have attracted scholars’ attention to the association between relationship breakup and the relations between fathers and their minor children. Pre-separation life course events and characteristics may influence this relationship. One important characteristic to be considered is the type of union in which ex-partners were in. In this article, we study the association between previous union type and post-dissolution father–child face-to-face contact and father’s satisfaction with the relationship, before and after controlling for factors related to selection into a cohabiting union. Using pooled data from the first wave of the Generations and Gender Survey for 11 European countries, it is shown that, models that do not control for characteristics typically connected with selection into different union types suggest that previously cohabiting fathers have less intensive contact with their child(ren) and are less satisfied with the relationship with their minor children. Taking into consideration the main socio-demographic father and child’s characteristics, this difference turns out not to be statistically significant. This research suggests that union type does not make a difference, confirming most previous studies of single European countries.
Characteristics, causes and impact of headache among a sample of physicians working during COVID-19 pandemic
Authors: Farag Sherien , ElSadek Ahmed , Salah-Eldin Waleed , Georgy Shady Samy , Fathy Mai 
Published: July 2022

Abstract
Background
Headache is considered a common health problem affecting physicians during Coronavirus disease-19 (COVID-19) pandemic and has direct impact on their productivity. Wearing personal protective equipment (PPE), stress and lack of sleep are common factors affecting their headache.

Results
Out of 165 participants, 38(23%) experienced new onset headache. Participants using Combined Face and eye PPE usage were at higher risk of developing headache compared to single PPE users, Participants wearing face shield were at higher risk of developing headache compared to eyewear non users.

Conclusion
COVID-19 hospital’s physicians may experience new-onset headache or change in their previously existing headache, mostly disposed by PPE eyewear and combined face and eye PPE.
In-situ formation of co particles encapsulated by graphene layers
Authors: Lee Minjeong , Kim Gyutae , Jeong Gyu Hyun , Yoon Aram , Lee Zonghoon , Ryu Gyeong Hee 
Published: July 2022

AbstractThe process of encapsulating cobalt nanoparticles using a graphene layer is mainly direct pyrolysis. The encapsulation structure of hybrids prepared in this way improves the catalyst stability, which greatly reduces the leaching of non-metals and prevents metal nanoparticles from growing beyond a certain size. In this study, cobalt particles surrounded by graphene layers were formed by increasing the temperature in a transmission electron microscope, and they were analyzed using scanning transmission electron microscopy (STEM). Synthesized cobalt hydroxide nanosheets were used to obtain cobalt particles using an in-situ heating holder inside a TEM column. The cobalt nanoparticles are surrounded by layers of graphene, and the number of layers increases as the temperature increases. The interlayer spacing of the graphene layers was also investigated using atomic imaging. The success achieved in the encapsulation of metallic nanoparticles in graphene layers paves the way for the design of highly active and reusable heterogeneous catalysts for more challenging molecules.
A single-nucleotide polymorphism of IL12A gene (rs582537 A/C/G) and susceptibility to chronic hepatitis B virus infection among Iraqi patients
Authors: Mohsen Rana T. , Al-Azzawi Raghad H. , Ad’hiah Ali H. 
Published: July 2022

AbstractA case–control study (80 patients with chronic hepatitis B virus [HBV] infection and 96 controls) was performed to evaluate the association of an IL12A gene variant (rs582537 A/C/G) with HBV infection. Allele G showed a significantly lower frequency in patients compared to controls (31.2 vs. 46.9%; probability [p] = 0.009; corrected p [pc] = 0.027) and was associated with a lower risk of HBV infection (odds ratio [OR] = 0.49; 95% confidence interval [CI] = 0.29–0.83). A similar lower risk was associated with genotypes CG (17.5 vs. 29.2; OR = 0.25; 95% CI = 0.08–0.81; p = 0.02) and GG (10.0 vs. 16.7; OR = 0.25; 95% CI = 0.07–0.91; p = 0.036), but the pc value was not significant (0.12 and 0.126, respectively). Serum IL-35 levels showed significant differences between individuals of different genotypes (p = 0.007). The highest median was associated with CA genotype (286.5 pg/mL), followed by genotypes CG (227.0 pg/mL), GG (206.5 pg/mL), CC (169.0 pg/mL), AA (137.5 pg/mL) and finally AG (125.0 pg/mL). In conclusion, rs582537 appears to be an important genetic variant that may influence not only susceptibility to HBV infection but IL-35 levels.
Radiotherapy or Autologous Stem-Cell Transplantation for Primary CNS Lymphoma in Patients Age 60 Years and Younger: Long-Term Results of the Randomized Phase II PRECIS Study
Authors: Houillier Caroline , Dureau Sylvain , Taillandier Luc , Houot Roch , Chinot Olivier , Moluçon-Chabrot Cécile , Schmitt Anna , Gressin Rémy , Choquet Sylvain , Damaj Gandhi , Peyrade Frédéric , Abraham Julie , Delwail Vincent , Gyan Emmanuel , Sanhes Laurence , Cornillon Jérôme , Garidi Reda , Delmer Alain , Al Jijakli Ahmad , Morel Pierre , Waultier Agathe , Paillassa Jérôme , Chauchet Adrien , Gastinne Thomas , Laadhari Mouna , Plissonnier Anne-Sophie , Feuvret Loïc , Cassoux Nathalie , Touitou Valérie , Ricard Damien , Hoang-Xuan Khê , Soussain Carole ,   on behalf of the LOC Network for CNS Lymphoma
Published: July 2022

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. We previously reported the results of a randomized phase II study in patients with newly diagnosed primary CNS lymphoma (age 18-60 years). Patients were treated with high-dose methotrexate-based induction chemotherapy followed by whole-brain radiotherapy (WBRT) or high-dose chemotherapy (thiotepa-busulfan-cyclophosphamide) with autologous stem-cell transplantation (ASCT). The median follow-up was 33 months. In this report, we provide long-term data (median follow-up, 8 years) regarding the outcomes and toxicities. Fifty-three and 44 patients received induction chemotherapy followed by WBRT or ASCT, respectively. Their 8-year event-free survival from random assignment was 67% and 39% in the ASCT and WBRT arms, respectively ( P = .03), with a significantly lower risk of relapse after ASCT (hazard ratio, 0.13; P < .001). One third of patients who relapsed after WBRT were alive after salvage treatment. Five and four patients died of ASCT and WBRT-related toxicities, respectively. The 8-year overall survival was 69% and 65% in the ASCT and WBRT arms, respectively (not significant). Balance (52% v 10%, P ≤ 0.001) and neurocognition (64% v 13%, P < .001) significantly deteriorated after WBRT compared with ASCT during the follow-up. This study shows that 40 Gy WBRT should be avoided in first-line treatment because of its neurotoxicity and suboptimal efficacy in reducing relapses while ASCT appears to be highly efficient in preventing relapses.
“Postreros acentos de la lira indiana”: The Discovery of the Cantares mexicanos in the Nineteenth Century
Authors: Colmenares David Horacio 
Published: July 2022

Abstract
The exhumation, in 1895, of the manuscript known as Cantares mexicanos y otros opúsculos in the Biblioteca Nacional de México made available for the first time authentic examples of sixteenth-century Nahua song (cuicatl). This article traces the history of the rediscovery of this manuscript and, more broadly, the history of the literary recuperation—through editing, translation, and study—of Nahua verbal art during the nineteenth century. By studying earlier unsuccessful attempts at incorporating the Cantares mexicanos into the emerging canon of Mexican literature, the article reconstructs the changing epistemic conditions and disciplinary realignments between Mexico and the United States that eventually made the 1895 exhumation possible. The Porfirian encounter with the Cantares not only made Nahua song available for an international audience but also established a paradigm of literary interpretation that continues to shape our understanding of this form of Indigenous verbal art to this day.
Good Neighbor, Bad Neighbor: Fact and Fiction in an FBI Investigation of Brazilian Literature during World War II
Authors: Gatti Maria G. 
Published: July 2022

AbstractBrazilian novelist Érico Veríssimo (1905–75) was an ambiguous subject of the Good Neighbor Policy: invited to the United States by the Department of State, he was also accused of anti-Americanism by the Federal Bureau of Investigation (FBI). An international police investigation into Veríssimo shows a Brazilian-US network in which literature is questioned both as a potential vehicle for subversion and as representative of its political context. Archival sources related to this investigation reveal how police agents searched for clues within fiction and how ideology often got lost in translation. Through a close reading of these sources, I explore the function of literature and the processes for its interpretation in political culture. This essay, by probing the contradictions of the Good Neighbor Policy and the transition from World War II to the Cold War, reveals how Brazilian and US police in collaboration applied the anti-Axis counterintelligence apparatus to the surveillance of Allied literature.