bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Spectral Extent of Phasic Suppression of Loudness and Distortion-Product Otoacoustic Emissions by Infrasound and Low-Frequency Tones
Authors: Jurado Carlos , Chow Man Yui Pat , Leung Ka Man Lydia , Larrea Marcelo , Vizuete Juan , de Cheveigné Alain , Marquardt Torsten 
Published: February 2022

AbstractWe investigated the effect of a biasing tone close to 5, 15, or 30 Hz on the response to higher-frequency probe tones, behaviorally, and by measuring distortion-product otoacoustic emissions (DPOAEs). The amplitude of the biasing tone was adjusted for criterion suppression of cubic DPOAE elicited by probe tones presented between 0.7 and 8 kHz, or criterion loudness suppression of a train of tone-pip probes in the range 0.125–8 kHz. For DPOAEs, the biasing-tone level for criterion suppression increased with probe-tone frequency by 8–9 dB/octave, consistent with an apex-to-base gradient of biasing-tone-induced basilar membrane displacement, as we verified by computational simulation. In contrast, the biasing-tone level for criterion loudness suppression increased with probe frequency by only 1–3 dB/octave, reminiscent of previously published data on low-side suppression of auditory nerve responses to characteristic frequency tones. These slopes were independent of biasing-tone frequency, but the biasing-tone sensation level required for criterion suppression was ~ 10 dB lower for the two infrasound biasing tones than for the 30-Hz biasing tone. On average, biasing-tone sensation levels as low as 5 dB were sufficient to modulate the perception of higher frequency sounds. Our results are relevant for recent debates on perceptual effects of environmental noise with very low-frequency content and might offer insight into the mechanism underlying low-side suppression.
The Influence of Fall Direction and Hip Protector on Fracture Risk: FE Model Predictions Driven by Experimental Data
Authors: Galliker Ellie S. , Laing Andrew C. , Ferguson Stephen J. , Helgason Benedikt , Fleps Ingmar 
Published: February 2022

AbstractHip fractures in older adults, which often lead to lasting impairments and an increased risk of mortality, are a major public health concern. Hip fracture risk is multi-factorial, affected by the risk of falling, the load acting on the femur, and the load the femur can withstand. This study investigates the influence of impact direction on hip fracture risk and hip protector efficacy. We simulated falls for 4 subjects, in 7 different impact directions (15° and 30° anterior, lateral, and 15°, 30°, 60°, and 90° posterior) at two different impact velocities (2.1 and 3.1 m/s), all with and without hip protector, using previously validated biofidelic finite element models. We found the highest number of fractures and highest fragility ratios in lateral and 15° posterior impacts. The hip protector attenuated femur forces by 23–49 % for slim subjects under impact directions that resulted in fractures (30° anterior to 30° posterior). The hip protector prevented all fractures (6/6) for 2.1 m/s impacts, but only 10% of fractures for 3.1 m/s impacts. Our results provide evidence that, regarding hip fracture risk, posterior-lateral impacts are as dangerous as lateral impacts, and they support the efficacy of soft-shell hip protectors for anterior- and posterior-lateral impacts.
Impaired left and right systolic ventricular capacity in corrected atrial septal defect patients
Authors: Karunanithi Zarmiga , Andersen Mads Jønsson , Mellemkjær Søren , Alstrup Mathias , Waziri Farhad , Clemmensen Tor Skibsted , Hjortdal Vibeke Elisabeth , Poulsen Steen Hvitfeldt 
Published: February 2022

AbstractResting right ventricular (RV) systolic function has in some studies been shown to be impaired after correction of an atrial septal defect (ASD) whereas impairment of left ventricular (LV) systolic function is uncertain. In the present study we examine the LV and RV systolic response to exercise in patients with a previously corrected ASD in order to investigate the myocardial capacity. Thirty-six adult ASD patients with a corrected isolated secundum ASD and eighteen adult age-matched controls underent a semi-supine exercise stress echocardiographic examination. At rest, LV parameters were comparable between groups, and RV global longitudinal strain (RV-GLS) was lower for the ASD group (−18.5%, 9﻿5% CI −20.0—−17.0%) compared with controls (−24.5%, 95% CI −27.7—−22.4%, p < 0.001). At peak exercise, LV ejection fraction (LVEF) was lower for ASD patients (61%, 95% CI 58–65%) compared with controls (68%, 95% CI 64–73% p = 0.01). Peak LV global longitudinal strain (LV-GLS) was borderline significantly lower (ASD: -18.4%, 95% CI −20.2—−16.6%, controls: −21.3%, 95% CI −23.6—−19.0%, p = 0.059). Both RVEF (ASD: 64%, 95% CI 60–68%, controls: 73%, 95% CI 65–80%, p = 0.05) and tricuspid annular plane systolic excursion (TAPSE) (ASD: 2.5 cm, 95% CI 2.3–2.7 cm, controls: 3.2 cm, 95% CI 2.9–3.6 cm, p < 0.001) at peak exercise were lower for ASD patients. Exercise assessed peak oxygen uptake was comparable between groups (ASD: 32.8 mL O2/kg/min, 95% CI 30.3–35.5 mL O2/kg/min, controls: 35.2 mL O2/kg/min, 95% CI 31.6–38.8 mL O2/kg/min, p = 0.3). Corrected ASD patients demonstrate a reduced LV and RV systolic exercise response decades after ASD correction whereas resting parameters of LV and RV systolic function were within normal range. The presence of subclinical systolic myocardial dysfunction during exercise might be associated with the long-term morbidities documented in this patient group.
Dry Reforming of Methane with Ni Supported on Mechanically Mixed Yttria-Zirconia Support
Authors: Ibrahim Ahmed Aidid , Kasim Samsudeen Olajide , Fakeeha Anis Hamza , Lanre Mahmud Sofiu , Abasaeed Ahmed Elhag , Abu-Dahrieh Jehad K. , Al-Fatesh Ahmed Sadeq 
Published: February 2022

AbstractThis study focuses on CH4 reforming with CO2 over Ni supported on yttria mixed with zirconia support. Different loading of yttria was used to enhance the performance of Ni towards achieving the optimum activity. The physicochemical properties of both fresh calcined and used catalysts were studied using a range of characterization techniques. The specific surface area measurement by the BET method showed a progressive increase in the area with an increase in yttria loading. The monoclinic (m- ZrO2) and tetragonal (t- ZrO2) phases were identified on all the samples by the XRD analysis. A reduction in the intensity of m- ZrO2 was observed on adding Ni to the catalysts while the diffraction pattern of crystalline yttria was not identified. The reducibility analysis showed the influence of yttria. It induces the formation of NiYO3 species with stronger active metal-support interaction. From the catalytic test, 5Ni/10Y-Z-3215 had the highest feed conversion of about 68 and 88% for CH4 and CO2 respectively. The TEM analysis showed a uniform dispersion of NiO particles over the mixed yttria-zirconia support with no agglomeration of the active metal particles after the reaction. The measurement of the quantity of carbon deposits by the TGA revealed that the increase in yttria loading enhanced the gasification of carbon deposits with 5Ni/20Y-Z-3215 recording the lowest weight loss of about 28%.
Graphical Abstract
Pareto Optimal Pension Risk Allocations
Authors: Muns Sander , Werker Bas J. M. 
Published: February 2022

AbstractWe consider a funded pension system where collective risks, in a simple Black-Scholes financial market, are allocated to the retirement savings of individual participants. In particular, we consider an allocation in such a way that the relative effect on total retirement wealth, that is, the sum of financial wealth and human capital, is the same for each participant. We show that this allocation is Pareto efficient. This stylized life-cycle fact inspired the new Dutch retirement system. Subsequently, we extend the allocation rule to a setting that includes annuity risk. This risk can be a traded risk (e.g., interest rate risk) as well as a non-traded risk (e.g., longevity risk). From our closed-form solutions, we identify the similarities between our optimal allocation rule and the allocation rule in the new Dutch retirement system. A numerical example illustrates our findings.
Construction, Characterization and Measurement of Fe–C and Pd–C HTFPs at CEM
Authors: Martín M. J. , Mantilla J. M. , Garcia-Izquierdo C. , del Campo D. 
Published: February 2022

AbstractThe current state of the art for temperature realization and dissemination above 1300 K is through the MeP-K-19 [1]. A limited set of high-temperature fixed points (HTFPs), an essential component of the MeP-K-19, has their temperature determined (Co–C (1597 K), Pt–C (1011 K) and Re–C (2747 K)). It is really a need to increase the HTFPs available for realization and dissemination of the high-temperature MeP-K. Fe–C (1426 K) and Pd–C (1765 K) has been less investigated, their thermodynamic temperature hasn’t been definitively determined, and they have been considered good candidates for their inclusion in the MeP-K in the EMPIR project “Real-K” [2]. This paper describes the construction, characterization, and measurement of HTFPs of Fe–C and Pd–C at Centro Español de Metrología as part of its contribution to the EMPIR project “Real-K”. Cells made have hybrid-type crucibles and they have been filled applying the piston method. A series of 6 HTFPs has been constructed: 3 Fe–C and 3 Pd–C. Points of inflection of the melting plateaux are repeatable after several initial measurement cycles. Their corresponding International Temperature Scale (ITS-90) temperatures (t90), referenced to a Cu fixed point, and thermodynamic temperatures (t), by means of the spectral responsivity calibration, have been calculated. Additionally, the influence of the furnace in the temperature assigned to the cells has been determined for different furnaces types (one zone and three zone) and different temperature profiles.
Mandatory vaccination and the ‘seat belt analogy’ argument: a critical analysis in the context of the Covid-19 pandemic
Authors: de Miguel Beriain Iñigo 
Published: February 2022

AbstractThe seat belt analogy argument is aimed at furthering the success of coercive vaccination efforts on the basis that the latter is similar to compulsory use of seat belts. However, this article demonstrated that this argument does not work so well in practice due to several reasons. The possibility of saving resources in health care does not usually apply in our societies, and the paternalist mentality that contributed to the implementation of seat belt–wearing obligation was predominant 30 years ago, but it does not apply at this moment. Furthermore, the risk/benefit analysis is totally different in both scenarios. In the case of seat belts, there is no way to discriminate between the users. In the case of vaccines, individuals present with unique circumstances that may differ substantially from those of another and might be foreseen a priori. This means that an analysis must be performed individually before vaccination is imposed. Finally, one must keep in mind that seat belts are often the only way in which we can protect third parties against a tragic hit by the occupant of another vehicle and are very efficient tools for this purpose. Vaccines, in contrast, do not always create sterilising immunity and are definitely not the only way by which we can avoid spreading a virus; immunity certificates, isolation, or even confinement may also serve as viable methods to achieve this purpose.
A queuing theory model for fog computing
Authors: Mas Lluís , Vilaplana Jordi , Mateo Jordi , Solsona Francesc 
Published: February 2022

AbstractUnder many scenarios where resources may be scarce or a good Quality of Service is a requirement, appropriately sizing components and devices is one of the main challenges. New scenarios, such as IoT, mobile cloud computing, mobile edge computing or fog computing, have emerged recently. The ability to design, model and simulate those infrastructures is critical to dimension them correctly. Queuing theory models provide a good approach to understanding how a given architecture would behave for a given set of parameters, thus helping to detect possible bottlenecks and performance issues in advance. This work presents a fog-computing modelling framework based on queuing theory. The proposed framework was used to simulate a given scenario allowing the possibility of adjusting the system by means of user-defined parameters. The results show that the proposed model is a good tool for designing optimal fog architectures regarding QoS requirements. It can also be used to fine-tune the designs to detect possible bottlenecks or improve the performance parameters of the overall environment.
Circumcentering Reflection Methods for Nonconvex Feasibility Problems
Authors: Dizon Neil D. , Hogan Jeffrey A. , Lindstrom Scott B. 
Published: February 2022

AbstractRecently, circumcentering reflection method (CRM) has been introduced for solving the feasibility problem of finding a point in the intersection of closed constraint sets. It is closely related with Douglas–Rachford method (DR). We prove local convergence of CRM in the same prototypical settings of most theoretical analysis of regular nonconvex DR, whose consideration is made natural by the geometry of the phase retrieval problem. For the purpose, we show that CRM is related to the method of subgradient projections. For many cases when DR is known to converge to a feasible point, we establish that CRM locally provides a better convergence rate. As a root finder, we show that CRM has local convergence whenever Newton–Raphson method does, has quadratic rate whenever Newton–Raphson method does, and exhibits superlinear convergence in many cases when Newton–Raphson method fails to converge at all. We also obtain explicit regions of convergence. As an interesting aside, we demonstrate local convergence of CRM to feasible points in cases when DR converges to fixed points that are not feasible. We demonstrate an extension in higher dimensions, and use it to obtain convergence rate guarantees for sphere and subspace feasibility problems. Armed with these guarantees, we experimentally discover that CRM is highly sensitive to compounding numerical error that may cause it to achieve worse rates than those guaranteed by theory. We then introduce a numerical modification that enables CRM to achieve the theoretically guaranteed rates. Any future works that study CRM for product space formulations of feasibility problems should take note of this sensitivity and account for it in numerical implementations.
Displacement based seismic assessment of base restrained retaining walls
Authors: Tiwari Rohit , Lam Nelson 
Published: February 2022

AbstractThe present work deals with assessment of earthquake-induced displacement of the base restrained retaining walls (RW’s). A detailed and rigorous finite element (FE) investigation has been carried out following the shaking table experiments on a scaled-down RW model. The FE simulations were performed by conducting several nonlinear time history analyses on a two-dimensional (2D) plane strain FE model of a prototype RW. The hardening and softening of backfill have been simulated by calibrating the Mohr Coulomb material model against the triaxial test results. Role of different backfill into the seismic performance of base restrained RW has also been investigated. It was observed that the cohesionless backfill has a slight influence on the earthquake induced displacement of base restrained RW’s. Amplification of horizontal acceleration in backfill has been observed with no direct correlation with the applied earthquake excitation. The understanding and findings based on shaking table experiment and FE simulations have been used for development of an analytical model for estimation of earthquake induced displacement of base restrained RW. The validity of proposed analytical model has also been examined against the shaking table experiment and FE simulation results.
A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability
Authors: Sher Anna , Niederer Steven A. , Mirams Gary R. , Kirpichnikova Anna , Allen Richard , Pathmanathan Pras , Gavaghan David J. , van der Graaf Piet H. , Noble Denis 
Published: February 2022

AbstractThere is an inherent tension in Quantitative Systems Pharmacology (QSP) between the need to incorporate mathematical descriptions of complex physiology and drug targets with the necessity of developing robust, predictive and well-constrained models. In addition to this, there is no “gold standard” for model development and assessment in QSP. Moreover, there can be confusion over terminology such as model and parameter identifiability; complex and simple models; virtual populations; and other concepts, which leads to potential miscommunication and misapplication of methodologies within modeling communities, both the QSP community and related disciplines. This perspective article highlights the pros and cons of using simple (often identifiable) vs. complex (more physiologically detailed but often non-identifiable) models, as well as aspects of parameter identifiability, sensitivity and inference methodologies for model development and analysis. The paper distills the central themes of the issue of identifiability and optimal model size and discusses open challenges.
Drug-related emergency department visits: prevalence and risk factors
Authors: Nymoen Lisbeth Damlien , Björk Malin , Flatebø Trude Eline , Nilsen Merethe , Godø Aasmund , Øie Erik , Viktil Kirsten Kilvik 
Published: February 2022

AbstractThe study aimed to investigate the prevalence of drug-related emergency department (ED) visits and associated risk factors. This retrospective cohort study was conducted in the ED, Diakonhjemmet Hospital, Oslo, Norway. From April 2017 to May 2018, 402 patients allocated to the intervention group in a randomized controlled trial were included in this sub-study. During their ED visit, these patients received medication reconciliation and medication review conducted by study pharmacists, in addition to standard care. Retrospectively, an interdisciplinary team assessed the reconciled drug list and identified drug-related issues alongside demographics, final diagnosis, and laboratory tests for all patients to determine whether their ED visit was drug-related. The study population’s median age was 67 years (IQR 27, range 19–96), and patients used a median of 4 regular drugs (IQR 6, range 0–19). In total, 79 (19.7%) patients had a drug-related ED visits, and identified risk factors were increasing age, increasing number of regular drugs and medical referral reason. Adverse effects (72.2%) and non-adherence (16.5%) were the most common causes of drug-related ED visits. Antithrombotic agents were most frequently involved in drug-related ED visits, while immunosuppressants had the highest relative frequency. Only 11.4% of the identified drug-related ED visits were documented by physicians during ED/hospital stay. In the investigated population, 19.7% had a drug-related ED visit, indicating that drug-related ED visits are a major concern. If not recognized and handled, this could be a threat against patient safety. Identified risk factors can be used to identify patients in need of additional attention regarding their drug list during the ED visit.
Alcohol Consumption and Cardiovascular Disease Risk: Placing New Data in Context
Authors: Hoek Anna G. , van Oort Sabine , Mukamal Kenneth J. , Beulens Joline W. J. 
Published: February 2022

Abstract

Purpose of Review
A clear link between excessive alcohol consumption and cardiovascular disease (CVD) has been established, but no consensus exists on the effects of moderate alcohol consumption on CVD.

Recent Findings
A lower risk of coronary heart disease and myocardial infarction among moderate drinkers compared to abstainers has been consistently observed in epidemiological studies and meta-analyses of these studies. However, ambiguity remains on the effect of alcohol on other CVDs and all-cause mortality. Short-term randomized controlled trials (RCT) have identified potentially beneficial effects of alcohol consumption on cardiovascular risk factors, but studies investigating genetic polymorphisms that influence alcohol consumption (i.e., Mendelian randomization) have yielded inconclusive results. To date, a long-term RCT providing causal evidence is lacking but urgently needed.

Summary
Triangulation of evidence from different study designs, including long-term RCTs, pragmatic trials and the evaluation of policy measures, combined will lead to the best available evidence.
Intergroup Contacts, Neighborhood Diversity, and Community Trust: the Asymmetrical Impact of Negative and Positive Experiences
Authors: Lundåsen Susanne Wallman 
Published: February 2022

AbstractIntergroup contacts can occur in many different places but are often studied only limited to a specific context. This study contributes with data that taps intergroup contacts that occur in both the private and the public sphere, using data from a large-scale survey directed towards individuals nested within 36 different municipalities and over 1,250 different neighborhoods with varying levels of visible minorities. The results also showed that just using the mere frequency of intergroup contacts is not sufficient to understand its association with community trust. Intergroup contacts that occurred in the neighborhood and in civil society organizations had a statistically significant association with community trust, while intergroup contacts that occurred in schools/workplaces and at home did not. The results also indicated that the neighborhood context moderated the impact of intergroup contacts. Whether contacts generated negative experiences mattered. Negative experiences mattered more for community trust especially for those who lived in diverse neighborhoods. The results indicated an asymmetry between the importance of positive and negative experiences of intergroup contacts for community trust.
Thermodynamic Modeling of Phosphorus Recovery from Wastewater
Authors: Keller Alexander , Burger Jakob , Steinmetz Heidrun , Hasse Hans , Kohns Maximilian 
Published: February 2022

AbstractMunicipal wastewater is an interesting source of phosphorus and several processes for the recovery of phosphorus from this source have been described. These processes yield magnesium ammonium phosphate (MAP), a valuable fertilizer. In these processes, pH shifts and the addition of chemicals are used to influence the species distribution in the solution such as to finally obtain the desired product and to prevent the co-precipitation of salts of heavy metal ions. Elucidating these species distributions experimentally is a challenging and cumbersome task. Therefore, in the present work, a thermodynamic model was developed that can be used for predicting the species distributions in the various steps of the recovery process. The model combines the extended Debye-Hückel equation for the prediction of activity coefficients with dissociation constants and solubility product data from the literature and contains no parameters that need to be adjusted to process data. The model was successfully tested by comparison to experimental data for the Stuttgart process from the literature and used for analyzing the different process steps. Furthermore, it was demonstrated how the model can be used for optimizing the process.
Graphical Abstract