bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using resilience and passion to overcome bullying and lack of meaning at work: a pathway to change-oriented citizenship
Authors: De Clercq Dirk , Pereira Renato 
Published: October 2022

PurposeThis study adds to human resource management research by addressing relevant questions about how and when employees' suffering from workplace bullying may direct them away from voluntary efforts to improve the organizational status quo. It postulates a mediating role of beliefs about work meaningfulness deprivation, as well as beneficial, moderating roles of two personal resources (resilience and passion for work) in this link.Design/methodology/approachThe research hypotheses were tested with survey data collected among employees who work in the construction retail sector.FindingsA critical reason that bullying victims refuse to exhibit change-oriented voluntarism is that they develop beliefs that their organization deprives them of meaningful work, which, as the authors theorize, enables them to protect their self-esteem resources. The extent to which employees can bounce back from challenging situations or feel passionate about work subdues this detrimental effect.Practical implicationsWhen employees feel upset about being bullied at work, their adverse work conditions may translate into work-related indifference (tarnished change-oriented citizenship), which then compromises employees' and the organization's ability to overcome the difficult situation. Managers should recognize how employees' personal resources can serve as protective shields against this risk.Originality/valueThis study details the detrimental role of demeaning workplace treatment in relation to employees' change-oriented organizational citizenship, as explained by their convictions that their organization operates in ways that make their work unimportant. It is mitigated by energy-enhancing personal resources.
Nicorandil mitigates amiodarone‐induced pulmonary toxicity and fibrosis in association with the inhibition of lung TGF‐β1/PI3K/Akt1‐p/mTOR axis in rats
Authors: Harb Inas , Ashour Hend , Rashed Laila A. , Mostafa Abeer , Samir Mai , Aboulhoda Basma Emad , El‐hanbuli Hala , Rashwan Eman , Mahmoud Heba 
Published: October 2022

AbstractThe long‐term side effect of the antiarrhythmic drug, amiodarone (AMIO), such as lung toxicity, remains a critical clinical issue. The previous knowledge denotes diverse antioxidant, anti‐inflammatory, and antifibrotic properties of the anti‐anginal drug, nicorandil (NI). Therefore, we aimed to investigate the possible protective effect of NI on pulmonary tissue remodelling following AMIO‐induced lung toxicity. The included rats were assigned into four equal groups (n = 8): (1) control, (2) control group that received NI 10 mg kg−1 day−1, (3) model group that received AMIO in a dose of 60 mg kg−1 day−1, and (4) treated group (AMIO‐NI) that were treated with AMIO plus NI as shown above. Drug administration continued for 10 weeks. AMIO resulted in deteriorated (p < 0.001) pulmonary functions accompanied by respiratory acidosis. AMIO showed an obvious histological injury score with intense collagen deposition, disturbed nitric oxide synthase enzymes (NOS/iNOS), and increased alpha smooth muscle actin expression. Furthermore, AMIO upregulated the transforming growth factor (TGF‐β1)/phosphoinositide‐3 kinase (PI3K)‐Akt1‐p/mammalian target of rapamycin (mTOR) axis, which determined the possible mechanism of AMIO on pulmonary remodelling. NI treatment significantly (p < 0.001) prevented the AMIO‐induced lung toxicity, as well as inhibited the TGF‐β1/PI3K/Akt1‐p/mTOR axis in the lung tissue of rats. The results were confirmed by an in‐vitro study.ConclusionThe current results revealed that NI was effective in preserving the lung structure and functions. Amelioration of the oxidative stress and modulation of TGF‐β1/PI3K/Akt1‐p/mTOR have been achieved. This study suggests NI administration as a preventive therapy from the serious pulmonary fibrosis side effect of AMIO.
The Role of Multi‐Level Governance in Shaping Regional Growth and Competitiveness in the Basque Country
Authors: Gray Caroline 
Published: October 2022

AbstractIn light of ongoing debates in England over the urgency of new devolution deals to ‘level up’ the country, this article investigates how devolved powers have been used to transform and sustain the economy in one of the most economically successful regions in Europe: the Basque Country. Drawing upon interviews conducted with Basque politicians, researchers and practitioners, the article examines the role that multi‐level governance and public‐private collaboration have played in shaping the region's economic development, as well as the challenges that derive from its complex institutional structure. The article concludes by suggesting that one of the most significant takeaways from the Basque experience is the importance of using devolution to build a collaborative web of actors and institutions at regional and local level with an enduring common knowledge and purpose that far outlives any one government, as well as the social capital needed to sustain that.
A prospective cohort study of cigarette smoking, alcohol drinking and liver cancer incidence in Chinese men
Authors: Zhang Yan , Li Zhuo Ying , Shen Qiu Ming , Tuo Jia Yi , Tan Jing Yu , Tan Yu Ting , Li Hong Lan , Xiang Yong Bing 
Published: October 2022

ObjectivesPopulation‐based prospective studies on the associations of cigarette smoking, alcohol drinking, and primary liver cancer remain limited in Mainland China. Our study was designed to evaluate such relationships in middle‐aged Chinese men.MethodsSelf‐reported habits of cigarette smoking and alcohol drinking were obtained from all cohort members at the baseline survey. The outcomes were identified through in‐person follow‐up and annual record linkage to multiple statistics of vital and cancer registration. Age‐adjusted and multivariable‐adjusted hazard ratio (HR) and their corresponding 95% confidence interval (CI) were estimated utilizing the Cox regression model.ResultsAfter a median follow‐up of 12.31 years, 329 cases of incident primary liver cancer occurred among 45 266 male participants. Compared with never smoker, former smoker was positively associated with liver cancer risk, with a multivariable‐adjusted HR of 1.42 (95% CI 1.02–1.98). Individuals who had smoked for more than 40 years had a 49% increased risk of liver cancer (HR≥40 years 1.49, 95% CI 1.04–2.14). The association of alcohol drinking with liver cancer showed no statistical significance.ConclusionsOur study provided evidence that cigarette smoking was positively associated with an increased liver cancer risk among Chinese men. Attention to such non‐viral modifiable risk factors to prevent liver cancer effectively is needed.
Novel nomogram model for predicting 6‐week mortality in liver cirrhosis patients with acute upper gastrointestinal bleeding
Authors: Zhou Yu Fen , Xu Ying , Ding Yan Fei , Yu Xiao Jun , Wu Yun Lin , Chen Ping , Zou Duo Wu 
Published: October 2022

ObjectiveTo develop and validate a nomogram for predicting 6‐week mortality in patients with liver cirrhosis and acute upper gastrointestinal bleeding (UGIB) and to compare it with other commonly used scoring systems.MethodsThis retrospective study included cirrhotic patients with acute UGIB hospitalized between January 2013 and December 2020. Random sampling was used to divide patients into the training (n = 676) and validation cohorts (n = 291) at a 7:3 ratio. Multivariate logistic stepwise regression was used to establish a model for predicting 6‐week mortality. Multiple indicators were used to validate the nomogram, including the area under the receiver operating characteristic curve (AUROC), calibration curve, and decision curve analysis (DCA).ResultsIn the training cohort, total bilirubin (TBIL) (odds ratio [OR] 1.75, 95% confidence interval [CI] 1.22–2.50), hemoglobin (Hb) (OR 0.97, 95% CI 0.95–0.99), C‐reactive protein (OR 2.79, 95% CI 1.30–6.07), prothrombin time (OR 1.17, 95% CI 1.05–1.30), and hepatic encephalopathy (stage I–II: OR 4.15, 95% CI 1.73–9.61; stage III–IV: OR 19.6, 95% CI 5.33–76.8) were identified as independent factors of 6‐week mortality. The AUROC of the UGIB‐LC score was 0.873 (95% CI 0.820–0.927), which was higher than that of the Child–Pugh score (0.781), model for end‐stage liver disease score (0.766), and neutrophil‐to‐lymphocyte ratio (0.716).ConclusionThe UGIB‐LC score is useful for predicting 6‐week mortality in patients with liver cirrhosis and acute UGIB, which is superior to the other three scoring systems.
An electrogenetic toggle switch model
Authors: Grozinger Lewis , Heidrich Elizabeth , Goñi‐Moreno Ángel 
Published: October 2022

AbstractSynthetic biology uses molecular biology to implement genetic circuits that perform computations. These circuits can process inputs and deliver outputs according to predefined rules that are encoded, often entirely, into genetic parts. However, the field has recently begun to focus on using mechanisms beyond the realm of genetic parts for engineering biological circuits. We analyse the use of electrogenic processes for circuit design and present a model for a merged genetic and electrogenetic toggle switch operating in a biofilm attached to an electrode. Computational simulations explore conditions under which bistability emerges in order to identify the circuit design principles for best switch performance. The results provide a basis for the rational design and implementation of hybrid devices that can be measured and controlled both genetically and electronically.
Nodule‐type pneumonitis mimicking lung abscess or tumor recurrence on chest computed tomography identified as osimertinib‐induced pneumonitis: A case report
Authors: Otsuki Ayumu , Homma Yuya , Yoshimi Michinori , Ito Hiroyuki , Nakashima Kei 
Published: October 2022

AbstractOsimertinib‐induced pneumonitis usually manifests as ground glass opacities (GGO) on chest computed tomography (CT) scans. Here, we encountered a case involving a 42‐year‐old woman who had nodule‐type pneumonitis mimicking lung abscess or tumor recurrence caused by osimertinib. When a nodular pattern is seen on the chest CT scan of a patient receiving osimertinib treatment, drug‐induced pneumonitis should be considered as a differential diagnosis. To the best of our knowledge, this is the first case of osimertinib‐induced pneumonitis that manifested as a nodule‐type pneumonitis mimicking lung abscess or tumor recurrence on chest CT scan.
Validity and test–retest reliability of the Ugandan version of the Pediatric Evaluation of Disability Inventory (PEDI‐UG) in children and youth with cerebral palsy
Authors: Amer Ahmed , Hermansson Liselotte , Jarl Gustav , Kamusiime Sauba , Forssberg Hans , Andrews Carin , Kakooza‐Mwesige Angelina , Eliasson Ann Christin 
Published: October 2022

AbstractBackgroundValidity of the Ugandan version of the Pediatric Evaluation of Disability Inventory (PEDI‐UG) was previously investigated on typically developing children. This study aimed to investigate the validity, test–retest reliability and minimal detectable change (MDC) of the PEDI‐UG in children and youth (C&Y) with cerebral palsy (CP).MethodA cross‐sectional study design with 118 C&Y with CP (44.7% girls) aged 10 months–22.5 years were included in the study; 37 of them completed the PEDI‐UG twice to investigate test–retest reliability, determined by calculating the intraclass correlation coefficient (ICC). Additionally, data from 249 typically developing children were used for differential item functioning (DIF) analysis. The validity of the PEDI‐UG was investigated by Rasch analysis. The Kruskal–Wallis test and Spearman's correlation coefficient were calculated to investigate associations between PEDI‐UG scores and external classification systems.ResultsThe principal component analysis of residuals indicated unidimensionality in all domains. The ICC values were excellent (0.98–0.99), and the MDCs were less than 6 and 13 (on a 0–100 scale) for the functional skills and caregiver assistance parts, respectively. The four‐category caregiver assistance rating scale fulfilled the criteria for the analysis of rating scale functioning. In total, 78 of 189 items in the functional skills domain and two items in the caregiver assistance domain demonstrated DIF between C&Y with CP and TD children. The Kruskal–Wallis test (p < 0.05) and Spearman's correlation (coefficients of −0.93 to −0.78) supported the validity of PEDI‐UG.ConclusionThe current diagnose‐specific version of PEDI‐UG demonstrates evidence for validity as a measure of ability in C&Y with CP in Uganda and other similar settings, being a promising tool for use in clinical practice and research. Conversion tables and MDC values are provided to facilitate clinical adoption of the measure.
Hypo‐ or hyperarousal? The mechanisms underlying social information processing in autism
Authors: Yi Li , Wang Qiandong , Song Ci , Han Zhuo Rachel 
Published: October 2022

AbstractAutistic children tend to show divergent social information processing, and controversies exist regarding the mechanisms underlying this processing. In this article, we summarize and categorize the current theories and evidence related to hypo‐ and hyperarousal accounts of social information processing in autism. The hypo‐arousal account proposes reduced motivation or sensitivity to process social information and is supported by behavioral, eye‐tracking, and neuroimaging studies. Recent evidence has challenged this account, highlighting the role of eye gaze in interpreting the hypo‐brain activation. The hyperarousal account posits that social context could evoke anxiety and discomfort in autistic children, which could interfere with their social information processing and result in social avoidance. Most research in this field has studied children and adolescents, but some studies have included adults since autism is a lifelong condition. Here, we highlight the importance of considering the heterogeneity of arousal patterns in autistic children when developing individualized supporting protocols.
‘My World, a click’: Preschool children photograph spaces of their daily lives
Authors: Askouni Nelli , Fakou Emilia , Vouvousira Stefania 
Published: October 2022

AbstractThe paper examines the ways in which preschool children represent the spaces of their daily lives. It is based on the analysis of photographs taken by pupils from two kindergartens located in non‐privileged neighbourhoods of Athens. The children photographed the spaces where they live and move, and talked about their photos. The analysis maps these spaces and explores the social parameters (social class, ethnicity) that shape the children's relationship with private and public space. Thus, photographs become tools that provide a deeper understanding of the children's social worlds and highlight the importance of the social spaces where their practices and experiences are shaped.
Self‐withdrawal from scheduled bariatric surgery: Qualitative study exploring patient and healthcare provider perspectives
Authors: Martin Mary I. , Ha Vanessa , Fasola Laurie , Dalgarno Nancy , Zevin Boris 
Published: October 2022

SummaryThe objective of the study was to explore the experience of patients who self‐withdrew from their scheduled bariatric surgery (BS) after completing the lengthy multidisciplinary assessment and optimization process, and to examine how these withdrawals affect healthcare providers (HCPs) in a Bariatric Centre of Excellence (BCoE). Interviews were conducted with patients who self‐withdrew, within 1 month, from scheduled BS. Additionally, a focus group with HCPs from the same BCoE was completed. The data were analysed using an inductive, emergent thematic approach with open coding in NVivo 12, with comparative analysis to identify common themes between groups. Eleven patients and 14 HCPs participated. HCPs identified several behavioural and logistical red flags among patients who self‐withdrew from scheduled BS. Patients and HCPs felt the decision was appropriate, owing to a patient's lack of mental preparedness for change, social supports, or fears of postoperative complications. HCPs reported frustration and described negative impacts on clinic efficiency. Additional mental health resources for patients contemplating self‐withdrawal, such as peer support, were suggested. In conclusion, a patient's decision to self‐withdraw from a scheduled BS is often sudden, definite, and associated with anxiety, fear of surgical risks and post‐operative complications. Additional mental health resources at a BCoE may be beneficial to support patients at risk of self‐withdrawal from scheduled BS.
Bi‐directional relations between behavioral problems and executive function: Assessing the longitudinal development of self‐regulation
Authors: Li Chen , Hart Emma R. , Duncan Robert J. , Watts Tyler W. 
Published: October 2022

AbstractDuring childhood, the ability to limit problem behaviors (i.e., externalizing) and the capacity for cognitive regulation (i.e., executive function) are often understood to develop in tandem, and together constitute two major components of self‐regulation research. The current study examines bi‐directional relations between behavioral problems and executive function over the course of childhood and adolescence. Relying on a diverse sample of children growing up in low‐income neighborhoods, we applied a random intercept cross‐lagged panel model to longitudinally test associations between behavioral problems and executive function from age 4 through age 16. With this approach, which disaggregated between‐ and within‐child variation, we did not observe significant cross‐lagged paths, suggesting that within‐child development in one domain did not strongly relate to development in the other. We also observed a moderate correlation between the stable between‐child components of behavioral problems and executive function over time in our preferred model, suggesting that these two domains may be relatively distinct when modeled from early childhood through adolescence.
Progressive slowing of clonic phase predicts postictal generalized EEG suppression
Authors: Vlachou Maria , Ryvlin Philippe , Arbune Anca Adriana , Armand Larsen Sidsel , Skræp Sidaros Annette , Cacic Hribljan Melita , Fabricius Martin , Beniczky Sándor 
Published: October 2022

AbstractObjectivePostictal generalized electroencephalography (EEG) suppression (PGES) is a surrogate marker of sudden unexpected death in epilepsy (SUDEP). It is still unclear which ictal phenomena lead to prolonged PGES and increased risk of SUDEP. Semiology features of generalized convulsive seizure (GCS type 1) have been reported as a predictor of prolonged PGES. Progressive slowing of clonic phase (PSCP) has been observed in GCSs, with gradually increasing inhibitory periods interrupting the tonic contractions. We hypothesized that PSCP is associated with prolonged PGES.MethodsWe analyzed 90 bilateral convulsive seizures in 50 consecutive patients (21 female; age: 11–62 years, median: 31 years) recruited to video‐EEG monitoring. Five raters, blinded to all other data, independently assessed the presence of PSCP. PGES and seizure semiology were evaluated independently. We determined inter‐rater agreement (IRA) for the presence of PSCP, and we evaluated its association, as well as that of other ictal features, with the occurrence of PGES, prolonged PGES (≥20 s) and very prolonged PGES (≥50 s) using multivariate logistic regression analysis.ResultsWe found substantial IRA for the presence of PSCP (percent agreement: 80%; beyond‐chance agreement coefficient: .655). PSCP was an independent predictor of the occurrence of PGES and prolonged PGES (p < .001). All seizures with very prolonged PGES had PSCP. GCS type 1 was an independent predictor of occurrence of PGES (p = .02) and prolonged PGES (p = .03) but not of very prolonged PGES. Only half of the seizures with very prolonged PGES were GCS type 1.SignificancePSCP predicts prolonged PGES, emphasizing the importance of gradually increasing inhibitory phenomena at the end of the seizures. Our findings shed more light on the ictal phenomena leading to increased risk of SUDEP. These phenomena may provide basis for algorithms implemented into wearable devices for identifying GCS with increased risk of SUDEP.
Do Merkel complexes initiate mechanical itch?
Authors: Bataille‐Savattier Adeline , Le Gall‐Ianotto Christelle , Lebonvallet Nicolas , Misery Laurent , Talagas Matthieu 
Published: October 2022

AbstractItch is a common sensation which is amenable to disabling patients' life under pathological and chronic conditions. Shared assertion easily limits itch to chemical itch, without considering mechanical itch and alloknesis, its pathological counterpart. However, in recent years, our understanding of the mechanical itch pathway, particularly in the central nervous system, has been enhanced. In addition, Merkel complexes, conventionally considered as tactile end organs only responsible for light touch perception due to Piezo2 expressed by both Merkel cells and SA1 Aβ‐fibres ‐ low threshold mechanical receptors (LTMRs) ‐, have recently been identified as modulators of mechanical itch. However, the tactile end organs responsible for initiating mechanical itch remain unexplored. The consensus is that some LTMRs, either SA1 Aβ‐ or A∂‐ and C‐, are cutaneous initiators of mechanical itch, even though they are not self‐sufficient to finely detect and encode light mechanical stimuli into sensory perceptions, which depend on the entire hosting tactile end organ. Consequently, to enlighten our understanding of mechanical itch initiation, this article discusses the opportunity to consider Merkel complexes as potential tactile end organs responsible for initiating mechanical itch, under both healthy and pathological conditions. Their unsuspected modulatory abilities indeed show that they are tuned to detect and encode light mechanical stimuli leading to mechanical itch, especially as they host not only SA1 Aβ‐LTMRs but also A∂‐ and C‐fibres.
Classify nodes based on their degree distribution: A more scalable method for influence maximization
Authors: Boroujeni Rouhollah Javadpour , Soleimani Seyfollah 
Published: October 2022

AbstractOne of the main problems in viral marketing is influence maximization (IM). With a social network and a predefined propagation model, the aim is to seek a subset of nodes that spread the influence widely into the network. Most scalable methods with provable approximation guarantees are presented for this problem based on the reverse influence sampling (RIS) framework. The RIS framework has two phases: sampling and node selection. The sampling phase encountered two challenges in the sampling phase: the number of required samples and the sampling method. Most methods have focused on the first challenge, that is, sample size, and have tried to provide a rigid sample size. In this paper, we focus on the second challenge: how to improve the precision of sampling. We propose to use stratified sampling rather than simple random sampling. Since the degree of each node is one of the affecting factors in the diffusion process. This issue leads us to use stratified sampling based on a degree distribution. The results show that with the application of the proposed method, the solution can estimate with fewer samples, which is faster than the state‐of‐the‐art methods.