bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the effect of fly ash content on the bonding performance of CFRP-concrete interface in sulfate environment
Authors: Liu Shengwei , Li Qi , Zhang Jiawei , Bai Chengyu , Zhao Kun , Jin Gaoming 
Published: September 2022

Abstract
The present study focuses on the investigation of the interfacial bond behavior of carbon fiber-reinforced polymer (CFRP)-concrete under dry-wet sulfate cycles by double-sided shear testing. Besides, the effects of fly ash content on the interfacial failure characteristics, interfacial debonding bearing capacity, CFRP strain distribution, and interfacial shear stress peak were analyzed. The interfacial debonding capacity, maximum CFRP strain, and peak value of interfacial shear stress of the CFRP-concrete interface decreased with increasing erosion time under the sulfate dry-wet cycle's action, according to the sulfate dry-wet cycle test results. The sulfate resistance of the CFRP-concrete interface increased after the addition of fly ash. However, the final decrease amplitude of interfacial debonding capacity, CFRP maximum strain, and maximum interfacial shear stress all reduced as the fly ash content increased. The effective bond length of the interface gradually increased with increasing erosion time; however, the change in fly ash content had little effect on the effective bond length, and the final effective bond length of the samples with different fly ash content was the same. Moreover, the CFRP-concrete interfacial bearing capacity model under the sulfate dry-wet cycle was established by introducing sulfate's comprehensive influence coefficient and considering fly ash content's influence. In conclusion, the comparative analysis of the prediction model and test results revealed that the prediction model could well reflect the degradation law of interfacial debonding bearing capacity with sulfate attack time.
GKLOMLI: A link prediction model for inferring miRNA-lncRNA interactions by using Gaussian kernel-based method on network profile and linear optimization algorithm
Authors: Wong Leon , Wang Lei , You Zhu-Hong , Yuan Chang-An , Huang Yu-An , Cao Mei-Yuan 
Published: September 2022

Abstract
Background
The limited knowledge of miRNA-lncRNA interactions is considered as an obstruction of revealing the regulatory mechanism. Accumulating evidence on Human diseases indicates that the modulation of gene expression has a great relationship with the interactions between miRNAs and lncRNAs. However, such interaction validation via CLIP-seq experiments inevitably costs too much money and time but with unsatisfactory results. Therefore, more and more computational prediction tools have been developed to offer many reliable candidates for a better design of further bio-experiments.
Methods
In this work, we proposed a novel link prediction model called GKLOMLI. Given an observed interaction profile without any test sample, the Gaussian kernel-based method was employed to output two similarity matrixes of miRNAs and lncRNAs. Based on the integrated matrix combined with similarity matrixes and the observed interaction network, a linear optimization-based link prediction model was trained for inferring miRNA-lncRNA interactions.
Results
To evaluate the performance of our proposed method, k-fold cross-validation (CV) and leave-one-out CV were implemented, in which each CV experiment was carried out 100 times on a training set generated randomly. The high AUCs at 0.8623 ± 0.0027 (2-fold CV), 0.9053 ± 0.0017 (5-fold CV), 0.9151 ± 0.0013 (10-fold CV), and 0.9236 (LOO-CV), illustrated the precision and reliability of our proposed method.
Conclusion
GKLOMLI with high performance is anticipated to be used to reveal underlying interactions between miRNA and their target lncRNAs and decipher the potential mechanisms of the complex diseases.
Model-predicted geometry variations to compensate material variability in the design of classical guitars
Authors: Brauchler Alexander , Gonzalez Sebastian , Vierneisel Manuel , Ziegler Pascal , Antonacci Fabio , Sarti Augusto , Eberhard Peter 
Published: September 2022

Abstract
Musical instrument making is often considered a mysterious form of art, its secrets still escaping scientific quantification. There is not yet a formula to make a good instrument, so historical examples are regarded as the pinnacle of the craft. This is the case of Stradivari’s violins or Torres guitars that serve as both models and examples to follow. Geometric copies of these instruments are still the preferred way of building new ones, yet reliably making acoustic copies of them remains elusive. One reason for this is that the variability of the wood used for instruments makes for a significant source of uncertainty -- no two pieces of wood are the same. In this article, using state-of-the-art methodologies, we show a method for matching the vibrational response of two guitar top plates made with slightly different materials. To validate our method, we build two guitar soundboards: one serving as a reference and the second acting as a copy to which we apply model-predicted geometry variations. The results are twofold. Firstly, we can experimentally validate the predictive capabilities of our numerical model regarding geometry changes. Secondly, we can significantly reduce the deviation between the two plates by these precisely predicted geometry variations. Although applied to guitars here, the methodology can be extended to other instruments, e.g. violins, in a similar fashion. The implications of such a methodology for the craft could be far-reaching by turning instrument-making more into a science than artistic craftsmanship and paving the way to accurately copy historical instruments of a high value.
Length-weight relationship and Condition factor of three freshwater eel fish species from Khan Sahib River, Tamil Nadu, India
Authors: Ponnuvel Mohanchander , Kaliyamoorthy Kalidasan , Narayanasamy Rajendran , M Ashiq Ur Rahman 
Published: September 2022

Abstract
The length-weight relationships (LWRs) and condition factor (Kn) for three freshwater fish species of Mastacembelidae (Synbranchiformes) lies in the Khan Sahib River is presented. Fishes were collected monthly from October 2017 to September 2018 using trap and drag nets of mesh sizes between 3.5 to 10 mm. The estimated parameters of ‘a’ and ‘b’ for the freshwater eels were ranged from − 4.101 to − 4.596 and 2.625 to 2.751, respectively. The mean and standard (Mean ± SE) relative condition factor (Kn) value ranged from 0.13 ± 0.01 to 0.34 ± 0.07 for Mastacembelus armatus, 0.14 ± 0.003 to 0.33 ± 0.08 for Macrognathus siamensis and 0.16 ± 0.01 to 0.26 ± 0.02 for Macrognathus aral. This work has provided a primary data base and calls for further studies of Mastacembelidae for deriving sustainable fishery strategies.
Patients' Attitudes towards Switching to National Volume-Based Procurement (NVBP) Drugs -A Qualitative Investigation in Wuhan, China
Authors: Tao Jinyi , Li Shihong , Xu Qiling , Gong Shiwei , Zeng Fang 
Published: September 2022

Abstract
Background
The implementation of the NVBP policy has generated considerable reductions in drug procurement prices and an increase in the market share of the NVBP drugs.This study aimed to investigate patients' attitudes towards switching to drugs of national volume-based procurement (NVBP) and identify their underlying influencing factors in Wuhan, China.
Methods
A total of 21 eligible patients from the Wuhan Union Hospital who were changed to use the NVBP medications between January 2022 and May 2022 were included in our study. Semi-structured face-to-face interviews were conducted to collect interview information and the interview data was analyzed by the Colaizzi seven-step method.
Results
Twenty-one semi-structured face-to-face interviews were conducted. The duration of each interview was 25–35 minutes and three themes related to patients' attitudes and their influencing factors were extracted, including (1) Patients' perception of the NVBP drugs; (2) Family and social influence to patients; (3) Medication habits of patients. This study found: 1) Most patients (n = 15) showed a positive attitude towards switching to NVBP medicines; 2)Almost all patients (n = 17) have felt a significant reduction in their medication cost after the implementation of the NVBP policy;3༉Advices from healthcare professionals and health insurance reimbursement policies showed great impacts on patient acceptance of the use of the NVBP drugs༛4༉Attitudes towards switching to the NVBP drugs varied considerably among patients with different severities of disease.
Conclusion
The implementation of the NVBP policy has significantly reduced the cost of healthcare for patients and has been supported by the majority of patients. However, some issues have been identified in the implementation of the policy in this study. Health professionals in general need to contribute more efforts to improve patients' preconceptions about the NVBP and boost their confidence in the NVBP drugs.
Evaluation And Applicability Of Tumour Budding And Poorly Differentiated Clusters As Additional Prognostic Markers In Colorectal Cancers
Authors: Sarkar Sagarika , Guha Rena , Mukherjee Srinjani , Kundu Sayan , Chakrabarti Sudipta 
Published: September 2022

Abstract
Purpose
Very few studies have assessed Tumour budding (TB) and poorly differentiated cell clusters (PDC) simultaneously in colorectal cancers (CRCs). The goal of this study is to establish a correlation between these two pertinent histological features and to reinforce the importance of their incorporation in routine histopathological reporting of CRC cases as a means to predict clinical outcome.
Methods
Resection specimens of colorectal carcinoma were included in the study. Patients who received presurgical therapy, or refused consent were excluded. PDC and TB were evaluated in routine haematoxylin and eosin stained histopathological sections taken from the advancing edge of the tumor. TB and PDC were reported by selecting a “hotspot” chosen after review of all available slides with invasive tumor. It was then followed by their correlation with other known prognostic factors.
Results
Spearman’s Rho calculator for strength of association between TB & PDC as well as association of TB and PDC individually with known prognostic factors revealed statistical significance. Correlation of TB and PDC with histologic grade, primary tumor (pT) and regional lymph node (pN) stage was done based on One-Way ANOVA Calculator, which yielded statistically significant results.
Conclusion
Evaluation of these two histological parameters in the same hotspot field at the tumor invasive front, plays a fundamental role in the definition of cancer aggressiveness and prediction of tumor behaviour.
A Study of Validity and Usability Evidence for Non-Technical Skills Assessment Tools in Simulated Adult Resuscitation Scenarios
Authors: Higham Helen , Greig Paul , Crabtree Nicholas , Hadjipavlou George , Young Duncan , Vincent Charles 
Published: September 2022

Abstract
Background:
Non-technical skills (NTS) assessment tools are widely used to provide formative and summative assessment for healthcare professionals and there are now many of them. This study has examined three different tools designed for similar settings and gathered evidence to test their validity and usability.
Methods:
Three NTS assessment tools designed for use in the UK were used by three experienced faculty to review standardized videos of simulated cardiac arrest scenarios: ANTS (Anesthetists’ Non-Technical Skills), Oxford NOTECHS (Oxford NOn-TECHnical Skills) and OSCAR (Observational Skill based Assessment tool for Resuscitation). Internal consistency, interrater reliability and quantitative and qualitative analysis of usability were analyzed for each tool.
Results:
Internal consistency and interrater reliability (IRR) varied considerably for the three tools across NTS categories and elements. Intraclass correlation scores of three expert raters ranged from poor (task management in ANTS [0.26] and situation awareness in Oxford NOTECHS [0.34]) to very good (problem solving in Oxford NOTECHS [0.81] and cooperation [0.84] and SA [0.87] in OSCAR). Furthermore, different statistical tests of IRR produced different results for each tool. Quantitative and qualitative examination of usability also revealed challenges in using each tool.
Conclusions:
The lack of standardization of NTS assessment tools and training in their use is unhelpful for healthcare educators and students. Educators require ongoing support in the use of NTS assessment tools for the evaluation of individual healthcare professionals or healthcare teams. Summative or high-stakes examinations using NTS assessment tools should be undertaken with at least two assessors to provide consensus scoring. In light of the renewed focus on simulation as an educational tool to support and enhance training recovery in the aftermath of COVID-19, it is even more important that assessment of these vital skills is standardized, simplified and supported with adequate training.
Conservation Priorities for the Genus Serjania (Sapindaceae, Paullinieae), a Key Component in the Secondary Succesion of the Seasonally Dry Tropical Forest in Bolivia
Authors: Coulleri Juan Pablo , Brem Marta C. 
Published: September 2022

AbstractBolivia is a country with a huge environmental variety, most of which are classified as seasonally dry forest, these ecosystems are threatened due land use, then subsequent abandonment promote the regrowth of the forest by secondary succession. Therefore, identify species that lead this process is key in order to protect them, being lianas good candidates as it theSerjaniagenus. Our objectives were defining conservation priorities ofSerjaniaspecies richness estimation; determine environmental factors that influence the distribution of these species and understand the dynamic of the SDTFs and secondary forest in America through present and futureSerjanianiche modelling. Our results set the conservation priorities in the Yungas slopes and the Chiquitano dry forest of Bolivia, these are the most diverse forests formations of the country, being the Chiquitano dry forest one of the most long-term stable American dry forests. Regarding to the environmental factors, for the species that only vegetate in the Chiquitano dry forest the temperature was the most important one, while the species that inhabit in the Yungas slope the precipitation regime represent the most influential variable for the presence of the species in these habitats. As for the dynamics of the Seasonally dry forest throughSerjaniadistribution modelling, an increase in the land coverage by these ones at the expense of their neighboring wet forest is projected, which also indicate the progression of the secondary forest due land use and climate change.
Influence of dentifrices containing tricalcium phosphate on dental enamel microhardness, color, and topography
Authors: Lopes Marina Paparotto , Gonçalves Iana Maria Costa , Garcia Raíssa Manoel , Sobral-Souza Danielle Ferreira , Aguiar Flávio Henrique Baggio , Lima Débora Alves Nunes Leite 
Published: September 2022

Abstract
Objetives: To evaluate the effect of using dentifrices containing tricalcium phosphate (β-TCP) on microhardness, enamel color, and topography before bleaching treatment with 35% hydrogen peroxide (HP).
Material and Methods: Fifty bovine incisor enamel/dentin blocks (4 × 4 × 2 mm) were randomized into five groups (n=10): negative control (no treatment; C), positive control (35% HP), Colgate Total 12 then 35% HP (CT 12 + 35% HP), Elmex Sensitive then 35% HP (ES + 35% HP), and Bianco Pro Clinical then 35% HP (BPC + 35% HP). Knoop microhardness (KHN) and scanning electron microscopy (SEM) were performed. The color was evaluated using CIELAB and CIEDE 2000. A significance of 5% was used.
Results: KHN was significantly higher in the BPC + 35% HP and ES + 35% HP groups than in the C and 35% HP groups (p=0.0295). ∆L was greater in the groups that received 35% HP than in the C group 24 hours after bleaching (p=0.0001). There was no significant difference between groups in ∆Eab* (p=0.0679) and ∆E00 (p=0.1463) 24 hours after bleaching.
Conclusion: Using dentifrices containing β-TCP before bleaching treatment with 35% HP increases enamel microhardness but does not significantly alter tooth color.
Clinical Relevance: Dentifrices containing β-TCP in their formulation increase enamel microhardness without interfering with substrate color when used with previous in-office tooth bleaching.
Anxiety, war exposure trauma and the mediating role of daily stressors in Romanian and Ukrainian civilians
Authors: Huțul Tudor-Daniel , Karner-Huțuleac Adina , Huțul Andreea 
Published: September 2022

Abstract
In this study, we want to point out the negative psychological impact on the population brought about by the war that started in Ukraine on February 24, 2022. In this research, we aimed to test for the mediating effect of daily stressors on the relationships between the centrality of the event and anxiety, respectively between the impact of the event and anxiety. The study was conducted on a sample of 738 people, the participants being individuals who lived either in Ukraine or outside Ukraine, but at a maximum distance of 100 km from the border (in Romania) when the conflict started. The results highlighted the mediating effect of daily stressors on the aforementioned relationships. At the end of the paper, we will list a number of limitations of the present study, as well as offer suggestions for future research.
Trigger Point Injections Followed by Immediate Myofascial Release in the Treatment of Myofascial Pelvic Pain
Authors: Lewis Gregory Kirk , Chen Anita , Craver Emily , Crook Julia , Carrubba Aakriti 
Published: September 2022

Abstract
Purpose
Pelvic floor physical therapy (PFPT) is first line therapy for treatment of myofascial pelvic pain (MFPP). Pelvic floor trigger point injections (PFTPI) are added if symptoms are refractive to conservative therapy or if patients experience a flare. The primary objective was to determine if a session of physical therapy with myofascial release immediately following PFTPI provides improved pain relief compared to trigger point injection alone.
Methods
This was a retrospective cohort analysis of 87 female patients with MFPP who underwent PFTPI alone or PFTPI immediately followed by PFPT. Visual analog scale (VAS) pain scores were recorded pre-treatment and 2 weeks post-treatment. The primary outcome was the change in VAS between patients who received PFTPI alone and those who received PFTPI followed by myofascial release.
Results
Of the 87 patients in this study, 22 received PFTPI alone and 65 patients received PFTPI followed by PFPT. The median pre-treatment VAS score was 8 for both groups. The median post-treatment score was 6 for the PFTPI only group and 4 for the PFTPI followed by PFPT group, showing a median change in VAS score of 2 and 4 respectively (p = 0.042). Seventy-seven percent of patients in the PFTPI followed by PFPT group had a VAS score improvement of 3 or more, while 45% of patients in the PFTPI only group had a VAS score improvement greater than 3 (p = 0.008).
Conclusions
PFTPI immediately followed by PFPT offered more improvement in pain for patients with MFPP. This may be due to greater tolerance of myofascial release immediately following injections.
Takeoff simulation of eVTOL airplane with coaxial propellers by fluid–rigid body interaction
Authors: Gomi Ritsuka , Takii Ayato , Yamakawa Masashi , Asao Shinichi , Takeuchi Seiichi , Nishimura Momoha 
Published: September 2022

Abstract
In this study, we adopt the coupled fluid–rigid body simulation using the moving computational domain method and the multi–axis sliding mesh method to the takeoff, hovering, and yawing flight of electric vertical takeoff and landing aircraft. The aircraft model has four pairs of coaxial propellers, and the computational domain is divided into three domains to move the aircraft and eight propeller domains to rotate the propellers. As a result, we clarify the behavior and aerodynamic force of the aircraft when the input values are determined by the automatic control. The results in the flow field also show that the downwash spreads in a crisscross pattern on the ground, that the wind reaches different ranges on the ground depending on the flight altitude, and that the coaxial propeller causes a asymmetry in the velocity field during yawing. Consequently, we conclude that this method is effective for the flight simulation of electric vertical takeoff and landing aircraft.
The impact of HIV on non-adherence for tamoxifen among women with breast cancer in South Africa
Authors: Ayeni Oluwatosin Adetayo , Chiwambutsa Shingirai , Chen Wenlong Carl , Kapungu Nyasha , Kanji Comfort , Thelingwani Roslyn , Murugan Nivashni , Mathiba Rofhiwa , Phakathi Boitumelo , Nietz Sarah , Ramiah Duvern , O’Neil Daniel S. , Jacobson Judith S. , Ruff Paul , Cubasch Herbert , Chirwa Tobias , Joffe Maureen , Masimirembwa Collen , Neugut Alfred I. 
Published: September 2022

Abstract
Purpose
Women living with HIV (WLWH) and breast cancer (BC) have worse overall survival than HIV-negative women with BC, and poor adherence to prescribed tamoxifen is known to contribute to poor survival.
Methods
Among 4,097 women diagnosed with breast cancer at six hospitals in the prospective South African Breast Cancer and HIV Outcomes (SABCHO) cohort study between July 2015 and December 2020, we focused on black women with stages I-III HR-positive breast cancer who were prescribed 20mg of adjuvant tamoxifen daily. We analyzed concentrations of tamoxifen and its metabolites using a triple quadruple mass spectrometer. We defined non-adherence as a tamoxifen level < 60ng/mL after 3 months of daily tamoxifen use. We compared tamoxifen-related side effects, and concurrent medication use among women with and without HIV and developed multivariable logistic regression models of tamoxifen non-adherence.
Results
Among 369 subjects, 78 (21.1%) were WLWH and 291 (78.9%) were HIV-negative. After a median (interquartile range) time of 13.0 (6.2–25.2) months since tamoxifen initiation, 208 (56.4%) women were non-adherent to tamoxifen. Women < 40 years of age were more likely to be non-adherent than women > 60 years (73.4% vs 52.6%, odds ratio (OR) = 2.49, 95% confidence interval (CI) = 1.26–4.94); likewise, WLWH (70.5% vs 52.6%, OR = 2.16, 95% CI = 1.26–3.70) than HIV-negative women. In an adjusted model WLWH had twice the odds of non-adherence to tamoxifen, compared to HIV-negative women (OR = 2.40, 95% CI = 1.11–5.20).
Conclusion
High rates of non-adherence to adjuvant tamoxifen may limit the overall survival of black South African women with HR-positive breast cancer, especially among WLWH.