bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of International Buyout Investments
Authors: Aldatmaz Serdar , Brown Greg W. , Demirgüç-Kunt Asli 
Published: April 2022

AbstractUsing a proprietary data set on international private equity activity, we study the determinants of buyout investments across 61 countries and 19 industries over the period of 1990 to 2017. We find that countries with cyclically strong economies, more active stock and credit markets, and better rule of law experience more buyout activity. Countries also receive more buyout capital following investor protection and contract enforcement reforms. The set of determinants we identify appear somewhat unique to buyout investments, because other forms of investment such as foreign direct investment, gross capital formation, investments in R&D, and M&A activity do not respond similarly to these factors.
CEO Marketability, Employment Opportunities, and Compensation: Evidence from Compensation Peer Citations
Authors: Choi Daewoung , Cicero David , Mobbs Shawn 
Published: April 2022

AbstractMandatory disclosure of CEO compensation peers signals potential outside opportunities for the cited CEOs by revealing which companies view them as viable executive candidates. CEOs cited often as compensation peers (especially by larger firms, which represent attractive employment opportunities) are more likely to leave for better positions or receive compensation increases. Equity-based awards following cites by larger firms have shorter vesting periods, suggesting these CEOs gain negotiating power relative to their boards. The disclosure requirement enhanced labor market transparency and led to higher compensation for highly cited CEOs without penalizing less cited CEOs, putting upward pressure on CEO compensation.
Comparison of executive dysfunction, proinflammatory cytokines, and appetite hormones between first-episode and multiple-episode bipolar disorders
Authors: Huang Kai-Lin , Chen Mu-Hong , Hsu Ju-Wei , Tsai Shih-Jen , Bai Ya-Mei 
Published: April 2022

AbstractBackgroundEvidence has demonstrated associations of bipolar disorder (BD) with cognitive impairment, dysregulated proinflammatory cytokines, and appetite hormones.AimTo compare executive dysfunction, proinflammatory cytokines, and appetite hormones between patients with first-episode and multiple-episode BDs.MethodsThis cross-sectional study included young adults aged 18 to 39 years who were diagnosed as having type 1 BD in the first or recurrent episode and a group of age-/sex-matched healthy controls. Data regarding patient characteristics, clinical symptoms, cytokines (C-reactive protein [CRP], interleukin-6, and tumor necrosis factor [TNF]-α), appetite hormones (leptin, adiponectin, ghrelin, and insulin), and executive function evaluated using the Wisconsin Card Sorting Test (WCST) were collected.ResultsA total of 112 participants (38 patients in the multiple-episode BD group, 31 patients in the first-episode BD group, and 43 in the control group) were included. Multivariate analysis revealed that patients in the multiple-episode BD group performed significantly worse in the WCST (P < .05) and had higher levels of ghrelin (P = .002), and lower levels of CRP (P = .040) than those in the first-episode BD group. Patients with BD had significantly higher TNF-α and ghrelin levels compared with the healthy controls. No significant associations of CRP, TNF-α, and ghrelin levels with executive function were observed.ConclusionsProfiles in proinflammatory cytokines and appetite hormones as well as executive function significantly differed between patients with first-episode and multiple-episode BDs and controls, which may suggest their potential roles in the clinical stages and pathophysiology of type 1 BD.
Mandatory pension savings and long-run debt accumulation: evidence from Danish low-wage earners
Authors: Andersen Henrik Yde , Hansen Niels Lynggård , Kuchler Andreas 
Published: April 2022

AbstractBased on two decades of Danish register data at the individual level, this paper finds that a 1-dollar increase in pension wealth leads to a 42-cent rise in total debt for a group of low-wage earners. Collective bargaining in the labor market provides time-sector variation in mandatory pension contribution rates, which we exploit in two empirical research designs; an event study and a cross-sectional instrumental variable regression model. Both methods demonstrate that the debt rise is accompanied by increased housing wealth and homeownership rates. Together, the empirical evidence indicates that mandatory pension contributions lead to a significant increase in net wealth, as well as in gross debt.
Random Forest Predictions of Fine Ash Concentration and Charging Processes From Experimentally Generated Volcanic Discharges
Authors: Rayborn L. , Jellinek A. M. 
Published: April 2022

AbstractExplosive volcanic plume rise is governed by the rate at which ambient air is ingested and heated by turbulent entrainment and mixing processes. A daunting observational challenge is to constrain the character of the underlying physical processes and their dependence on complex particle‐particle and particle‐gas interactions. Important clues may lie in the particle‐particle momentum exchange that gives rise to related electrical discharges near the vent during supersonic eruptions. Recent laboratory studies of positive and negative shock‐tube‐generated volcanic discharges show a correlation between fine ash concentration and the magnitude and number of positive discharges. Charge generation via collisions (triboelectrification) is hypothesized to be more efficient with high ash concentrations and at high decompression rates because collisions between particles become more frequent under these conditions. To understand the experimental data in greater detail, we train and implement a regression‐based random forest algorithm to quantitatively predict concentrations of fine ash using discharge count, magnitude and polarity as predictors. Using a metric for variable importance, we find in all, high pressure (HP, ≥10 MPa), and high ash mass experiments (HM, >22g) that positive discharge properties are most important when predicting fine ash concentration, consistent with triboelectrification as the predominant charging process under these conditions. This mechanism is not constrained for low‐pressure (LP, <10 MPa) conditions, suggesting a potential threshold decompression rate condition for this class of charging. This result provides insight into why near‐vent lightning is not a ubiquitous feature of explosive eruptions.
Linking Coherent Anticyclonic Eddies in the Iceland Basin to Decadal Oceanic Variability in the Subpolar North Atlantic
Authors: Kondetharayil Soman Arunraj , Chafik Léon , Nilsson Johan 
Published: April 2022

AbstractThe Iceland Basin in the eastern Subpolar North Atlantic is an eddy‐rich region characterized by intense anticyclonic eddy activity. Our study present the variability of coherent Anticyclonic Eddies (AEs) generated in this region, using satellite altimetry and two ocean eddy tracking algorithms. The yearly count of AEs in the Iceland Basin reveals a decadal variability similar to that of ocean heat content change in the eastern subpolar gyre. Periods with higher number of AEs coincide with periods of increased ocean heat content, and vice versa. However, both algorithms agree that more than 50% of the detected AEs are confined to the central Iceland Basin. The annual number of AEs also tracks zonal shifts of the subpolar front, a variable that can explain about 53 (77)% of the interannual (decadal) variability of AEs in the Iceland Basin. Finally, a Lagrangian approach is used to demonstrate that the amount of subtropical versus subpolar water masses reaching the Iceland Basin appears to influence, via baroclinic instability, the generation of AEs.
OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor
Authors: Fan Chuannan , Wang Qian , van der Zon Gerard , Ren Jiang , Agaser Cedrick , Slieker Roderick C. , Iyengar Prasanna Vasudevan , Mei Hailiang , ten Dijke Peter 
Published: April 2022

AbstractOvo-like transcriptional repressor 1 (OVOL1) is a key mediator of epithelial lineage determination and mesenchymal–epithelial transition (MET). The cytokines transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP) control the epithelial–mesenchymal plasticity (EMP) of cancer cells, but whether this occurs through interplay with OVOL1 is not known. Here, we show that OVOL1 is inversely correlated with the epithelial–mesenchymal transition (EMT) signature, and is an indicator of a favorable prognosis for breast cancer patients. OVOL1 suppresses EMT, migration, extravasation, and early metastatic events of breast cancer cells. Importantly, BMP strongly promotes the expression of OVOL1, which enhances BMP signaling in turn. This positive feedback loop is established through the inhibition of TGF-β receptor signaling by OVOL1. Mechanistically, OVOL1 interacts with and prevents the ubiquitination and degradation of SMAD family member 7 (SMAD7), which is a negative regulator of TGF-β type I receptor stability. Moreover, a small-molecule compound 6-formylindolo(3,2-b)carbazole (FICZ) was identified to activate OVOL1 expression and thereby antagonizing (at least in part) TGF-β-mediated EMT and migration in breast cancer cells. Our results uncover a novel mechanism by which OVOL1 attenuates TGF-β/SMAD signaling and maintains the epithelial identity of breast cancer cells.
Treatment of SARS-CoV-2-induced pneumonia with NAD+ and NMN in two mouse models
Authors: Jiang Yisheng , Deng Yongqiang , Pang Huanhuan , Ma Tiantian , Ye Qing , Chen Qi , Chen Haiyang , Hu Zeping , Qin Cheng-Feng , Xu Zhiheng 
Published: April 2022

AbstractThe global COVID-19 epidemic has spread rapidly around the world and caused the death of more than 5 million people. It is urgent to develop effective strategies to treat COVID-19 patients. Here, we revealed that SARS-CoV-2 infection resulted in the dysregulation of genes associated with NAD+ metabolism, immune response, and cell death in mice, similar to that in COVID-19 patients. We therefore investigated the effect of treatment with NAD+ and its intermediate (NMN) and found that the pneumonia phenotypes, including excessive inflammatory cell infiltration, hemolysis, and embolization in SARS-CoV-2-infected lungs were significantly rescued. Cell death was suppressed substantially by NAD+ and NMN supplementation. More strikingly, NMN supplementation can protect 30% of aged mice infected with the lethal mouse-adapted SARS-CoV-2 from death. Mechanically, we found that NAD+ or NMN supplementation partially rescued the disturbed gene expression and metabolism caused by SARS-CoV-2 infection. Thus, our in vivo mouse study supports trials for treating COVID-19 patients by targeting the NAD+ pathway.
Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson’s disease
Authors: Si Xiaoli , Guo Tao , Wang Zhiyun , Fang Yi , Gu Luyan , Cao Lanxiao , Yang Wenyi , Gao Ting , Song Zhe , Tian Jun , Yin Xinzhen , Guan Xiaojun , Zhou Cheng , Wu Jingjing , Bai Xueqin , Liu Xiaocao , Zhao Guohua , Zhang Minming , Pu Jiali , Zhang Baorong 
Published: April 2022

AbstractAlpha-synucleinopathy is postulated to be central to both idiopathic rapid eye movement sleep behaviour disorder (iRBD) and Parkinson’s disease (PD). Growing evidence suggests an association between the diminished clearance of α-synuclein and glymphatic system dysfunction. However, evidence accumulating primarily based on clinical data to support glymphatic system dysfunction in patients with iRBD and PD is currently insufficient. This study aimed to use diffusion tensor image analysis along the perivascular space (DTI-ALPS) to evaluate glymphatic system activity and its relationship to clinical scores of disease severity in patients with possible iRBD (piRBDs) and those with PD. Further, we validated the correlation between the ALPS index and the prognosis of PD longitudinally. Overall, 168 patients with PD, 119 piRBDs, and 129 healthy controls were enroled. Among them, 50 patients with PD had been longitudinally reexamined. Patients with PD exhibited a lower ALPS index than those with piRBDs (P = 0.036), and both patient groups showed a lower ALPS index than healthy controls (P < 0.001 andP = 0.001). The ALPS index and elevated disease severity were negatively correlated in the piRBD and PD subgroups. Moreover, the ALPS index was correlated with cognitive decline in patients with PD in the longitudinal analyses. In conclusion, DTI-ALPS provided neuroimaging evidence of glymphatic system dysfunction in piRBDs and patients with PD; however, the potential of assessing the pathological progress of α-synucleinopathies as an indicator is worth verifying. Further development of imaging methods for glymphatic system function is also warranted.
Modelling the effect of SMP production and external carbon addition on S-driven autotrophic denitrification
Authors: Guerriero Grazia , Mattei Maria Rosaria , Papirio Stefano , Esposito Giovanni , Frunzo Luigi 
Published: April 2022

AbstractThe aim of this study was to develop a mathematical model to assess the effect of soluble microbial products production and external carbon source addition on the performance of a sulfur-driven autotrophic denitrification (SdAD) process. During SdAD, the growth of autotrophic biomass (AUT) was accompanied by the proliferation of heterotrophic biomass mainly consisting of heterotrophic denitrifiers (HD) and sulfate-reducing bacteria (SRB), which are able to grow on both the SMP derived from the microbial activities and on an external carbon source. The process was supposed to occur in a sequencing batch reactor to investigate the effects of the COD injection on both heterotrophic species and to enhance the production and consumption of SMP. The mathematical model was built on mass balance considerations and consists of a system of nonlinear impulsive differential equations, which have been solved numerically. Different simulation scenarios have been investigated by varying the main operational parameters: cycle duration, day of COD injection and quantity of COD injected. For cycle durations of more than 15 days and a COD injection after the half-cycle duration, SdAD represents the prevailing process and the SRB represent the main heterotrophic family. For shorter cycle duration and COD injections earlier than the middle of the cycle, the same performance can be achieved increasing the quantity of COD added, which results in an increased activity of HD. In all the performed simulation even in the case of COD addition, AUT remain the prevailing microbial family in the reactor.
Bio-strengthening of cementitious composites from incinerated sugarcane filter cake by a calcifying bacterium Lysinibacillus sp. WH
Authors: Ditta Zerlinda Mara , Tanapongpisit Nantawat , Saenrang Wittawat , Fongkaew Ittipon , Chainakun Poemwai , Seemakram Wasan , Boonlue Sophon , Sata Vanchai , Ekprasert Jindarat 
Published: April 2022

AbstractThis study investigated Microbially Induced Calcite Precipitation (MICP) technology to improve the mechanical properties of cementitious composites containing incinerated sugarcane filter cake (IFC) using a calcifying bacteriumLysinibacillussp. WH. Both IFC obtained after the first and second clarification processes, referred to as white (IWFC) and black (IBFC), were experimented. This is the first work to investigate the use of IBFC as a cement replacement. According to the X-ray fluorescence (XRF) results, the main element of IWFC and IBFC was CaO (91.52%) and SiO2(58.80%), respectively. This is also the first work to investigate the use of IBFC as a cement replacement. We found that the addition of strain WH could further enhance the strength of both cementitious composites up to ~ 31%, while reduced water absorption and void. Microstructures of the composites were visualized using a scanning electron microscope (SEM). The cement hydration products were determined using X-ray diffraction (XRD) followed by Rietveld analysis. The results indicated that biogenic CaCO3was the main composition in enhancing strength of the IBFC composite, whereas induce tricalcium silicate (C3S) formation promoting the strength of IWFC composite. This work provided strong evidence that the mechanical properties of the cementitious composites could be significantly improved through the application of MICP. In fact, the strength of IFC-based cementitious composites after boosting by strain WH is only 10% smaller than that of the conventional Portland cement. While using IFC as a cement substitute is a greener way to produce environmentally friendly materials, it also provides a solution to long-term agro-industrial waste pollution problems.
Foregut organ progenitors and their niche display distinct viscoelastic properties in vivo during early morphogenesis stages
Authors: Dzementsei Aliaksandr , Barooji Younes F. , Ober Elke A. , Oddershede Lene B. 
Published: April 2022

AbstractMaterial properties of living matter play an important role for biological function and development. Yet, quantification of material properties of internal organs in vivo, without causing physiological damage, remains challenging. Here, we present a non-invasive approach based on modified optical tweezers for quantifying sub-cellular material properties deep inside living zebrafish embryos. Material properties of cells within the foregut region are quantified as deep as 150 µm into the biological tissue through measurements of the positions of an inert tracer. This yields an exponent, α, which characterizes the scaling behavior of the positional power spectra and the complex shear moduli. The measurements demonstrate differential mechanical properties: at the time when the developing organs undergo substantial displacements during morphogenesis, gut progenitors are more elastic (α = 0.57 ± 0.07) than the neighboring yolk (α = 0.73 ± 0.08), liver (α = 0.66 ± 0.06) and two mesodermal (α = 0.68 ± 0.06, α = 0.64 ± 0.06) progenitor cell populations. The higher elasticity of gut progenitors correlates with an increased cellular concentration of microtubules. The results infer a role of material properties during morphogenesis and the approach paves the way for quantitative material investigations in vivo of embryos, explants, or organoids.
Phase separation driven by interchangeable properties in the intrinsically disordered regions of protein paralogs
Authors: Chiu Shih-Hui , Ho Wen-Lin , Sun Yung-Chen , Kuo Jean-Cheng , Huang Jie-rong 
Published: April 2022

AbstractParalogs, arising from gene duplications, increase the functional diversity of proteins. Protein functions in paralog families have been extensively studied, but little is known about the roles that intrinsically disordered regions (IDRs) play in their paralogs. Without a folded structure to restrain them, IDRs mutate more diversely along with evolution. However, how the diversity of IDRs in a paralog family affects their functions is unexplored. Using the RNA-binding protein Musashi family as an example, we applied multiple structural techniques and phylogenetic analysis to show how members in a paralog family have evolved their IDRs to different physicochemical properties but converge to the same function. In this example, the lower prion-like tendency of Musashi-1’s IDRs, rather than Musashi-2’s, is compensated by its higher α-helical propensity to assist their assembly. Our work suggests that, no matter how diverse they become, IDRs could evolve different traits to a converged function, such as liquid-liquid phase separation.
Sexual behaviour during COVID-19: a repeated cross-sectional survey in Victoria, Australia
Authors: Goller Jane L. , Bittleston Helen , Kong Fabian Yuh Shiong , Bourchier Louise , Williams Henrietta , Malta Sue , Vaisey Alaina , Lau Andrew , Hocking Jane S. , Coombe Jacqueline 
Published: April 2022

Background During 2020, the State of Victoria (Australia) experienced two COVID-19 waves. Both resulted in community lockdowns followed by eased restrictions. We examined variation of sexual behaviour in Victorians over time during COVID-19. Methods We conducted a repeated online survey at four timepoints corresponding with two lockdown (LD1, LD2) and two reduced restriction (RR1, RR2) periods in Victoria. A convenience sample of participants aged ≥18 years was recruited via social media and asked about their recent (past 4 weeks) sexual behaviour. Using multivariable logistic regression, we investigated variation in sexual behaviour between surveys. Results A total of 1828 surveys were completed; 72% identified as female, 69% were aged 18–29 years, 90% were metropolitan residents. The proportion reporting recent partnered sex ranged from 54.9% (LD2) to 70.2% (RR1). Across all timepoints, the most common sexual partners were regular (81.5%, n = 842) and 10.8% (n = 111) reported casual partners (e.g. hook-ups). Compared with LD1, respondents were >2-fold more likely to report casual partner(s) during reduced restrictions (RR1: aOR 2.0; 95% CI 1.1–3.7; RR2: aOR 2.8; 95% CI 1.3–5.9). Across all timepoints, 26.6% (n = 486) reported using dating apps. Compared with LD1, dating app use for face-to-face activities (e.g. dates, hook-ups) was >4-fold higher during reduced restrictions (RR1: aOR 4.3; 95% CI 2.3–8.0; RR2: aOR 4.1; 95% CI 1.9–8.8). App use for distanced activities (e.g. sexting, virtual dates) was highest during LD1 (48.8%) than other periods. Conclusions In this convenience sample, self-reported sexual behaviours fluctuated between lockdowns and reduced restrictions. While dating apps may provide a mechanism for virtual connections, this may be temporary until physical connections are possible.
Conserved and divergent chaperoning effects of Hsp60/10 chaperonins on protein folding landscapes
Authors: Sadat Anwar , Tiwari Satyam , Sunidhi S. , Chaphalkar Aseem , Kochar Manisha , Ali Mudassar , Zaidi Zainab , Sharma Akanksha , Verma Kanika , Narayana Rao Kannan Boosi , Tripathi Manjul , Ghosh Asmita , Gautam Deepika , Atul  , Ray Arjun , Mapa Koyeli , Chakraborty Kausik 
Published: April 2022

Significance
Hsp60/10 chaperonins are critical for cellular proteostasis in all kingdoms of life. In this study, we present that Hsp60/10 across different species have differences in the cavity properties and correlatively in their capability to remove entropic traps in folding pathways of GroEL/ES substrates; this is affected majorly by differences in the negative-charge density inside the chaperonin cavity. This dissimilarity leads to a remarkable difference between Hsp60/10 homologs in buffering mutational variations. However, most of them can remove nonnative contacts during folding of their substrates and alter the way the polypeptide chain undergoes hydrophobic collapse. We show that these homologs may have evolved specific modes of folding assistance by modulating cavity properties according to the requirements of their substrates.
Anomalous phase separation in a correlated electron system: Machine-learning–enabled large-scale kinetic Monte Carlo simulations
Authors: Zhang Sheng , Zhang Puhan , Chern Gia-Wei 
Published: April 2022

SignificancePhase separation is crucial to the functionalities of many correlated electron materials with notable examples including colossal magnetoresistance in manganites and high-Tcsuperconductivity in cuprates. However, the nonequilibrium phase-separation dynamics in such systems are poorly understood theoretically, partly because the required multiscale modeling is computationally very demanding. With the aid of machine-learning methods, we have achieved large-scale dynamical simulations in a representative correlated electron system. We observe an unusual relaxation process that is beyond the framework of classical phase-ordering theories. We also uncover a correlation-induced freezing behavior, which could be a generic feature of phase separation in correlated electron systems.