bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of epigenetic and metabolomic biomarkers indicating biological age
Authors: Kuiper Lieke M. , Polinder-Bos Harmke A. , Bizzarri Daniele , Vojinovic Dina , Vallerga Costanza L. , Beekman Marian , Dollé Martijn E.T. , Ghanbari Mohsen , Voortman Trudy , Reinders Marcel J.T. , Verschuren W.M. Monique , Slagboom P. Eline , van den Akker Erik B. , van Meurs Joyce B.J. 
Published: December 2022

AbstractBiological age captures a person’s age-related risk of unfavorable outcomes using biophysiological information. Multivariate biological age measures include frailty scores and molecular biomarkers. These measures are often studied in isolation, but here we present a large-scale study comparing them.In two prospective cohorts (n=3,196), we compared epigenetic (DNAm Horvath, DNAm Hannum, DNAm PhenoAge, DNAm GrimAge) and metabolomic-based (MetaboAge, MetaboHealth) biomarkers in reflection of biological age, as represented by five frailty measures and overall mortality.We observed that mortality-trained biological age markers, DNAm GrimAge and MetaboHealth, outperformed age-trained biomarkers in frailty reflection and mortality prediction. The associations of DNAm GrimAge and MetaboHealth with frailty and mortality were independent of each other and of the frailty score mimicking clinical geriatric assessment.Epigenetic, metabolomic, and clinical biological age markers seem to capture different aspects of aging. These findings suggest that mortality-trained molecular markers may provide novel phenotype reflecting biological age and strengthen current clinical geriatric health and well-being assessment.
Comprehension of acoustically degraded speech in Alzheimer’s disease and primary progressive aphasia
Authors: Jiang Jessica , Johnson Jeremy CS , Requena-Komuro Maï-Carmen , Benhamou Elia , Sivasathiaseelan Harri , Chokesuwattanaskul Anthipa , Nelson Annabel , Nortley Ross , Weil Rimona S , Volkmer Anna , Marshall Charles R , Bamiou Doris–Eva , Warren Jason D , Hardy Chris JD 
Published: December 2022

ABSTRACTSuccessful communication in daily life frequently depends on accurate decoding of speech signals that are acoustically degraded by challenging listening conditions. This process presents the brain with a demanding computational task that is vulnerable to neurodegenerative pathologies. However, despite recent intense interest in the link between hearing impairment and dementia, daily hearing measures (such as degraded speech comprehension) in these diseases remain poorly defined. Here we addressed this issue in a cohort of 19 patients with typical Alzheimer’s disease (AD) and 31 patients representing canonical syndromes of primary progressive aphasia (PPA), in relation to 25 healthy age-matched controls. As a model paradigm for the acoustically degraded speech signals of daily life, we used noise-vocoding: synthetic division of the speech signal into a variable number of frequency channels constituted from amplitude-modulated white noise, such that fewer channels convey less spectrotemporal detail thereby reducing intelligibility. We investigated the impact of noise-vocoding on recognition of spoken three-digit numbers and used psychometric modelling to ascertain the threshold number of noise-vocoding channels required for 50% intelligibility by each participant. Associations of noise-vocoded speech intelligibility threshold with general demographic, clinical and neuropsychological characteristics and regional grey matter volume (defined by voxel-based morphometry of patients’ brain MR images) were also assessed. Compared with healthy older controls, all patient groups had a significantly higher mean noise-vocoded speech intelligibility threshold, particularly marked in logopenic variant and nonfluent-agrammatic variant PPA and significantly higher in AD than in semantic variant PPA (all p<0.05). Noise-vocoded intelligibility threshold discriminated dementia syndromes (in particular, Alzheimer’s disease) well from healthy controls. Further, this central hearing measure correlated with overall disease severity but not with measures of peripheral hearing or clear speech perception. Neuroanatomically, after correcting for multiple voxel-wise comparisons in pre-defined regions of interest, impaired noise-vocoded speech comprehension across dementia syndromes was significantly associated (p<0.05) with atrophy of left planum temporale, angular gyrus and anterior cingulate gyrus: a cortical network widely implicated in processing degraded speech signals. Taken together, our findings suggest that the comprehension of acoustically altered speech captures a central process relevant to daily hearing and communication in major dementia syndromes, with novel diagnostic and therapeutic implications.
Brain activation by a VR-based motor imagery and observation task: An fMRI study
Authors: Nunes João D. , Vourvopoulos Athanasios , Blanco-Mora Diego Andrés , Jorge Carolina , Fernandes Jean-Claude , i Badia Sergi Bermudez , Figueiredo Patrícia 
Published: December 2022

AbstractTraining motor imagery (MI) and motor observation (MO) tasks is being intensively exploited to promote brain plasticity in the context of post-stroke rehabilitation strategies. The desired brain plasticity mechanisms may benefit from the use of closed-loop neurofeedback, embedded in brain-computer interfaces (BCIs) to provide an alternative non-muscular channel. These can be further augmented through embodied feedback delivered through virtual reality (VR). Here, we used functional magnetic resonance imaging (fMRI) to map brain activation elicited by a VR-based MI-MO BCI task called NeuRow and compared with a conventional non-VR, and MI-only, task based on the Graz BCI paradigm. We found that, in healthy adults, NeuRow elicits stronger brain activation when compared to the Graz task, as well as to an overt motor execution task, recruiting large portions of the parietal and occipital cortices in addition to the motor and premotor cortices. In particular, NeuRow activates the mirror neuron system (MNS), associated with action observation, as well as visual areas related with visual attention and motion processing. We studied a cohort of healthy adults including younger and older subgroups, and found no significant age-related effects in the measured brain activity. Overall, our findings suggest that the virtual representation of the arms in a bimanual MI-MO task engage the brain beyond conventional MI tasks, even in older adults, which we propose could be explored for effective neurorehabilitation protocols.
IFNγ protects motor neurons from oxidative stress via enhanced global protein synthesis in FUS-associated Amyotrophic Lateral Sclerosis
Authors: Assoni Amanda Faria , Guerrero Erika N. , Wardenaar René , Oliveira Danyllo , Bakker Petra L. , Carvalho Valdemir Melechco , Okamoto Oswaldo Keith , Zatz Mayana , Foijer Floris 
Published: December 2022

AbstractAmyotrophic lateral sclerosis type 6 (ALS6) is a familial subtype of ALS linked to Fused in Sarcoma (FUS) gene mutation. FUS mutations lead to decreased global protein synthesis, but the mechanism that drives this has not been established. Here, we used ALS6 patient-derived induced pluripotent stem cells (hIPSCs) to study the effect of the ALS6 FUSR521Hmutation on the translation machinery in motor neurons (MNs). We find, in agreement with findings of others, that protein synthesis is decreased in ALS6 MNs. Furthermore, ALS6 MNs are more sensitive to oxidative stress and display reduced expression of TGF-β and mTORC gene pathways when stressed. Finally, we show that IFNγtreatment reduces apoptosis of ALS6 MNs exposed to oxidative stress and partially restores the translation rates in ALS6 MNs. Overall, these findings suggest that a functional IFNγresponse is important for FUS-mediated protein synthesis, possibly by FUS nuclear translocation in ALS6.Highlights and eTOC blurbALS6 patient-derived motor neurons show decreased viability and reduced production of innate immune cytokines following oxidative stressFUS cytoplasmic localization coincides with decreased protein synthesis ratesIFNγtreatment of ALS6 patient-derived motor neurons reduces apoptosis and ameliorates translation rates resulting from oxidative stress
Informal learning for employees’ protection behavior in organizations
Authors: Sundaram Ranjany , Shetty Snehal , Palakkeel Prashobhan 
Published: December 2022

Purpose
The purpose of this study is to examine the impact of informal and formal learning processes on protection behavior with a focus on the role of resilience as a potential mediator.

Design/Methodology/Approach
Using web-based survey questionnaires on informal and formal learning, protection behavior, and resilience the survey collected information from 329 employees working in various organizations in India. Structural equation modeling was used to analyze employees’ protection behavior in protecting organization resources.

Findings
Findings indicate that informal learning has a significant positive effect on employees’ protection behavior, in protecting organization information. Further, resilience is found to be having a small mediation effect on informal learning and protection behavior relationships. Formal learning has no impact on employees’ protection behavior.

Originality/value
One of the scarce empirical research works that have substantiated the informal learning effect on organization protection behavior among employees.

Practical implications
Informal learning increasing the protection behavior has implications for the organizations in promoting social interactions. Formal learning not impacting protection behavior implies that organizations may reduce the expenses of sending their employees to formal training on information protection behavior.
BIM and real estate valuation: challenges, potentials and lessons for future directions
Authors: Jafary Peyman , Shojaei Davood , Rajabifard Abbas , Ngo Tuan 
Published: December 2022

PurposeBuilding information modeling (BIM) is a striking development in the architecture, engineering and construction (AEC) industry, which provides in-depth information on different stages of the building lifecycle. Real estate valuation, as a fully interconnected field with the AEC industry, can benefit from 3D technical achievements in BIM technologies. Some studies have attempted to use BIM for real estate valuation procedures. However, there is still a limited understanding of appropriate mechanisms to utilize BIM for valuation purposes and the consequent impact that BIM can have on decreasing the existing uncertainties in the valuation methods. Therefore, the paper aims to analyze the literature on BIM for real estate valuation practices.Design/methodology/approachThis paper presents a systematic review to analyze existing utilizations of BIM for real estate valuation practices, discovers the challenges, limitations and gaps of the current applications and presents potential domains for future investigations. Research was conducted on the Web of Science, Scopus and Google Scholar databases to find relevant references that could contribute to the study. A total of 52 publications including journal papers, conference papers and proceedings, book chapters and PhD and master's theses were identified and thoroughly reviewed. There was no limitation on the starting date of research, but the end date was May 2022.FindingsFour domains of application have been identified: (1) developing machine learning-based valuation models using the variables that could directly be captured through BIM and industry foundation classes (IFC) data instances of building objects and their attributes; (2) evaluating the capacity of 3D factors extractable from BIM and 3D GIS in increasing the accuracy of existing valuation models; (3) employing BIM for accurate estimation of components of cost approach-based valuation practices; and (4) extraction of useful visual features for real estate valuation from BIM representations instead of 2D images through deep learning and computer vision.Originality/valueThis paper contributes to research efforts on utilization of 3D modeling in real estate valuation practices. In this regard, this paper presents a broad overview of the current applications of BIM for valuation procedures and provides potential ways forward for future investigations.
Females’ customer engagement with eco-friendly restaurants in Instagram: the role of past visits
Authors: Ballester Estefania , Ruiz-Mafé Carla , Rubio Natalia 
Published: December 2022

Purpose
The purpose of this study is to examine the effect on the customer brand engagement (CBE) of followers of an eco-friendly restaurant of their perceptions of the originality of the firm-generated content posted online by the restaurant and the effect of CBE on brand advocacy and behavioural intentions to visit the restaurant, paying special attention to the moderating role of past visits to the restaurant.

Design/methodology/approach
The hypotheses were tested using structural equation modelling with a sample of 491 female Instagram users who follow the online account of a particular eco-friendly dining establishment. Two group comparisons were conducted to test the moderating effects in relationships between CBE and consumer–brand interactions (behavioural intentions to visit the restaurant and brand advocacy).

Findings
Followers’ perceptions of the originality of the material posted by the eco-friendly restaurant had a positive influence on CBE which, in turn, affected brand advocacy and behavioural intentions to visit the restaurant. Past visits moderated the relationship between CBE and consumer–brand interactions.

Practical implications
This study offers restaurants an understanding of how to develop marketing strategies targeted at females on visual-based social networks; it is shown that original posts encourage favourable responses, such as CBE, brand advocacy and behavioural intentions. Managers should organise events and invite their female followers to visit the restaurant.

Originality/value
This study adds to the knowledge about customer engagement by explaining how firm-generated content posted on Instagram drives CBE and provides specific suggestions as to how restauranteurs might engage online with their clients. This study goes beyond direct effects and analyses the moderating role of past visits to the restaurant on the relationships between CBE and consumer–brand interactions (visiting intentions and brand advocacy).
Trade misinvoicing and domestic resource mobilization in Nigeria
Authors: Afolabi Joshua Adeyemi 
Published: December 2022

Purpose
Mobilizing domestic resources has been a daunting task for the Nigerian government given its growing fiscal responsibilities and the limited domestic resources at its disposal. However, little is known empirically about the role trade misinvoicing plays in this regard. Hence, this study evaluates the effect of trade misinvoicing on domestic resource mobilization in Nigeria.

Design/methodology/approach
Sourcing annual data spanning 1981–2018 on key variables of interest, this study adopts the Dynamic Ordinary Least Squares (DOLS) estimation method to evaluate the effect of trade misinvoicing on domestic resource mobilization in Nigeria.

Findings
In conformity with extant studies, the result reveals that trade misinvoicing adversely affects domestic resource mobilization. It also showed that domestic resources are highly sensitive to the dynamics of trade misinvoicing in Nigeria. Other determinants of domestic resource mobilization in Nigeria include public debt, official development assistance, trade openness and inflation.

Practical implications
The study suggests the need to take expeditious and pragmatic actions against the rising tides of trade misinvoicing in Nigeria with a view to improving the volume of domestic resources required for financing development objectives. This will facilitate the achievement of the Sustainable Development Goals (SDGs) and enable Nigeria to maximally enjoy gains from trade.

Originality/value
There is an overwhelming evidence on the effect of foreign capital inflows on the Nigerian economy but, little is known about the effects of foreign capital outflows. Specifically, there is a dearth of studies on the effect of trade misinvoicing on domestic resource mobilization, particularly for Nigeria. Therefore, this study fills this knowledge gap by evaluating the effect of trade misinvoicing on domestic resource mobilization in Nigeria.
Too emotional to succeed: entrepreneurial narratives in a prosocial setting
Authors: Naimi Asma , Arenas Daniel , Kickul Jill , Awan Sahar 
Published: December 2022

PurposeThe purpose of this paper is to provide insight into the effectiveness of cognitive and emotional appeals to mobilize resources in prosocial crowdfunding settings that combine the creation of economic and social value.Design/methodology/approachThe authors quantitatively measure the effectiveness of cognitive and emotional appeals in the entrepreneurial narratives of 2,098 entrepreneurs from 55 countries shared via the Kiva platform by performing multiple regression analysis.FindingsThe findings suggest that using cognitive appeals can attract more resources than using emotional appeals. In fact, using affective language in general, and negative emotion words specifically, can be detrimental and attract fewer resources.Originality/valueThe authors contribute to the entrepreneurship and social entrepreneurship literature by linking insights from the Elaboration Likelihood Model (ELM) of persuasion and motivational framing to understand resource mobilization in prosocial settings. This study demonstrates that cognitive and emotional appeals could lead to different outcomes in contexts where entrepreneurial narratives are all framed as “doing good” and individuals allocating resources are highly socially motivated.
Mentoring leaders of tomorrow: insights on the role of college directors
Authors: Kamarudin Fadzliyati , Adams Donnie 
Published: December 2022

PurposeMentoring is a crucial aspect of leadership development. However, the knowledge base about mentoring with regard to student leadership development is still emerging and has yet to be explored in depth. Thus, this paper explores college directors' mentorship, as a form of faculty mentoring, in developing students' leadership in Malaysia.Design/methodology/approachA qualitative research design was utilized, by which semi-structured interviews were used to collect data from four college directors. Data were analyzed and coded using ATLAS.ti 9.FindingsThe findings provide new insights into how college directors mentor students to develop them as leaders. Specifically, the findings show that directors, as transformational leaders, can play a significant mentoring function in enhancing students' leadership via role-modeling for students to accumulate leadership-related knowledge and skills.Research limitations/implicationsThis study centered on the role of college directors who are transformational leaders, mentoring with authority, vision and role-modeling for student leaders' leadership development.Originality/valueThe study offers empirical evidence about the significance of college directors' mentorship in enhancing student leadership in Malaysia.
Using bug-in-ear technology as a coaching technique: a scoping review
Authors: Gander Tim , Dann Christopher 
Published: December 2022

PurposeThis scoping review discusses how bug-in-ear (BIE) technology has been used to coach teachers and pre-service teachers in special education, general education and initial teacher education (ITE). The purpose of the review is to identify the range of practices in implementing BIE technology and the potential impacts on teachers, learners, coaches and professional learning and development (PLD) providers.Design/methodology/approachThe PRISMA framework guided the structure of the scoping review. Four leading educational database searches informed initial results. Peer review ensured that inclusion and exclusion requirements were rigorously followed. Two screenings, a hand search and snowballing found 20 relevant studies for review.FindingsBIE coaching is a cost-effective approach to support the development of teachers and pre-service teachers, with the potential to improve learner outcomes. Delivering coaching remotely yields the widest range of benefits for PLD providers. Technology issues persist; therefore, simple approaches work most effectively. There are opportunities to explore coaching attributes required for BIE coaching and how BIE feedback can differ from in-person feedback.Practical implicationsPLD should be based on available resources; however, it is possible to train participants to use BIE in a short amount of time. Pre-determined prompts should be co-constructed between the coach and the teacher. Prompts should be delivered within 3–5 s of the teaching behaviour and consist of positive, corrective, questioning and goal-orientated statements.Originality/valueThis is the first evidence-based review of BIE coaching that highlights effective practices in special education, general education and ITE. This review also explores how BIE coaching is used with teachers, which has not been covered in detail.
Asymmetric investments in exchange relationships, perceived supplier shirking and cross-functional information sharing as a moderator
Authors: Pandey Rahul , Rungtusanatham Manus , Oppong-Tawiah Divinus 
Published: December 2022

PurposeWith asymmetric investments in exchange (i.e. sourcing) relationships, both sourcing firms and suppliers invest but one party invests more than the other. This paper aims to examine the associations between asymmetric (i.e. unequal) investments in exchange relationships and the tendency of the strategic supplier base to shirk as perceived by the sourcing firm, as well as the moderation effects of cross-functional information sharing within a sourcing firm on these associations.Design/methodology/approachThe authors analyzed survey data from 500 US middle-market manufacturers via ordinary least squares (OLS) estimation. Besides appropriate controls, the authors also employed the heteroskedasticity-based instrumental variable approach to ensure that analytical inferences are not influenced by endogeneity.FindingsOn average, when a sourcing firm invests more than its strategic supplier base into their exchange relationships, the perceived tendency of the strategic supplier base to shirk decreases. This negative association is more pronounced when a sourcing firm facilitates cross-functional information sharing. Conversely, when the strategic supplier base invests more than the sourcing firm into their exchange relationships, the perceived tendency of the strategic supply base to shirk is not detected unless the sourcing firm facilitates cross-functional information sharing.Originality/valuePrior research reveals that investments by a sourcing firm or by suppliers influence supplier shirking. This paper provides new evidence as to how and why asymmetric investments in exchange relationships relate to the perceived tendency of the strategic supplier base to shirk and new evidence as to how and why cross-functional information sharing safeguards against this tendency when investments in exchange relationships are unequal.