bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Cognitive Functioning After Surgical Resection of Language-related, Eloquent-area, High-grade Gliomas Under Awake Craniotomy
Authors: Hendi Kasra , Rahmani Mohamad , Larijani Amirhossein , Ajam Zibadi Hamideh , Raminfard Samira , Shariat Moharari Reza , Gerganov Venelin , Alimohamadi Maysam 
Published: April 2022

Background:
Dominant-hemisphere tumors, especially gliomas, as infiltrative tumors, frequently affect cognitive functioning. Establishing a balance between extensive resection, which is proven to result in longer survival, and less extensive resection, in order to maintain more cognitive abilities, is challenging.

Objective:
To evaluate changes in cognitive functioning before and after surgical resection of language-related, eloquent-area, high-grade gliomas under awake craniotomy.

Method:
We provided individuals with newly diagnosed high-grade gliomas of the language-related eloquent areas with the same standard of care, including surgical resection of the glioma using intraoperative sensory-motor and cognitive mapping under awake craniotomy, and the same protocol for chemoradiotherapy. Cognitive functioning was assessed using Addenbrooke’s Cognitive Examination—Revised (ACE–R) at four time points (preoperatively, early after surgery, and 3 and 6 months postoperatively).

Results:
The preoperative evaluation revealed a range of cognitive impairments in 70.7% of the individuals, affecting all of the cognitive subdomains (mostly attention and visuospatial abilities). Overall cognitive functioning (ie, ACE–R score) dropped by 13.5% (P = 0.169) early postoperatively. At the 3-month evaluation, an average of 15.3% (P = 0.182) recovery in cognitive functioning was observed (mostly in verbal fluency: 39.1%). This recovery improved further, reaching 29% (P < 0.001) at the 6-month evaluation. The greatest improvement occurred in verbal fluency: 68.8%, P = 0.001.

Conclusion:
Extensive resection of eloquent-area gliomas with the aid of modern neuroimaging and neuromonitoring techniques under awake craniotomy is possible without significant long-term cognitive sequela.
Ambulatory detection of isolated REM sleep behavior disorder combining actigraphy and questionnaire
Authors: Brink-Kjaer Andreas , Gupta Niraj , Marin Eric , Zitser Jennifer , Sum-Ping Oliver , Hekmat Anahid , Bueno Flavia , Cahuas Ana , Langston James , Jennum Poul , Sorensen Helge B.D. , Mignot Emmanuel , During Emmanuel 
Published: April 2022

ABSTRACTBackgroundIsolated rapid-eye-movement sleep behavior disorder (iRBD) is in most cases a prodrome of neurodegenerative synucleinopathies, affecting 1-2% of middle-aged and older adults, however accurate ambulatory diagnostic methods are lacking. Questionnaires lack specificity in non-clinic populations. Wrist actigraphy can detect characteristic features in individuals with RBD, however high frequency actigraphy has rarely been used.ObjectivesTo develop a machine learning classifier using high frequency (1-second resolution) actigraphy and a short patient survey for detecting iRBD with high accuracy and precision.MethodsAnalysis of ≥7 nights home actigraphy data and 9-item questionnaire (RBD Innsbruck inventory and 3 synucleinopathy prodromes of subjective hyposmia, constipation and orthostatic dizziness) in a dataset including 42 patients with iRBD, 21 sleep clinic patients with other sleep disorders, and 21 community controls.ResultsThe actigraphy classifier achieved 95.2% (95% CI: 88.3 - 98.7) sensitivity and 90.9% (95% CI: 82.1 - 95.8) precision. The questionnaire classifier achieved 90.6% accuracy and 92.7% precision, exceeding performance of RBD-I and prodromal questionnaire alone. Concordant predictions between actigraphy and questionnaire reached specificity and precision of 100% (95% CI: 95.7 - 100.0) with 88.1% sensitivity (95% CI: 79.2 - 94.1) and outperformed any combination of actigraphy plus single question on RBD or prodromal symptoms.ConclusionsActigraphy detected iRBD with high accuracy in a mixed clinical and community cohort. This cost-effective fully remote procedure can be used to diagnose iRBD in specialty outpatient settings and has potential for large scale screening of iRBD in the general population.
Effect of two methods of soft tissue augmentation for socket closure on soft tissue landmarks and ridge dimensions- Results from software-based analysis of clinical data
Authors: Chandra Rampalli Viswa , Bhagyasree Medisetty , Sathwika Pulijala , Reddy Aileni Amarender 
Published: April 2022

ABSTRACTPurposeThe aim of this study was to evaluate the effect of connective tissue grafts (CTG) and pediculated connective tissue grafts (P-CTG) for extraction socket closure on soft tissue landmarks and ridge dimensions.Methods45 subjects were randomized into two groups, where the soft tissue closure of extraction sockets was done by pediculated connective tissue grafts (P-CTG group) and connective tissue grafts (CTG group). On photographs taken at different time-points, four markers corresponding to marginal gingiva (MG), mucogingival junction (MGJ), mesial papilla (MP) and distal papilla (DP) were placed. After image alignment and stacking, the markers were tracked through five photographs taken during the course of the therapy. The displacement, total displacement (TD), divergence and angle of maximum divergence (AMD) for each marker were recorded. Buccolingual and mesiodistal dimensions of edentulous sites were measured, and the difference from the baseline to 6-months in both the dimensions was calculated and was described as buccolingual gain (BL gain) and mesiodistal gain (ML gain) respectively.ResultsIntergroup comparison of displacement and divergence of markers across both the groups showed varying levels of significance. P-CTG resulted in higher buccolingual dimensions at 3 months (P=0.001) and 6 months (P=0.002) when compared to the CTG group. From baseline to 6-months, the BL and MD gains were 2.82±1.29mm & 1.68±1.12mm and 1.27±0.65mm & 1.48±0.67mm in P-CTG and CTG group respectively. In the P-CTG group, TD (r=0.4;P=0.001) & AMD (r=0.5;P=0.05) of MG and TD (r=0.2;P=0.005) of MGJ resulted in BL gains. In the CTG group, TD (r=0.7;P=0.004) and AMD (r=0.3;P=0.004) of MP and AMD of MGJ was associated with a significant BL gain.ConclusionsP-CTG and CTG had significant effects on displacement and divergence of soft tissue landmarks respectively. The relocation of these landmarks, seem to result in an improvement in the buccolingual dimensions of the post-extraction ridge.
Clinical evaluation of an automated, rapid mariPOC® antigen test in screening of symptomatics and asymptomatics for SARS-CoV-2 infections
Authors: Gunell Marianne , Rantasärkkä Kaisa , Arjonen Rita , Sandén Antti , Vuorinen Tytti 
Published: April 2022

AbstractA novel automated mariPOC® SARS-CoV-2 antigen test was evaluated in a Health care center laboratory among symptomatic and asymptomatic individuals seeking SARS-CoV-2 testing. According to the national testing strategy, RT-PCR was used as a reference method. A total of 962 subjects were included in this study, 4.8% (46/962) of their samples were SARS-CoV-2 RT-PCR positive, and 87% (40/46) of these were from symptomatics. Among the symptomatics, the overall sensitivity of the mariPOC® SARS-CoV-2 test was 82.5% (33/40), though the sensitivity increased to 97.1% (33/34) in samples with a Ct value <30. The mariPOC® SARS-CoV-2 test detected 2/6 PCR positive samples among the asymptomatics, four cases that remained antigen test negative had Ct values between 28 and 36. The specificity of the mariPOC® SARS-CoV-2 test was 100% (916/916). The evaluation showed that the mariPOC® SARS-CoV-2 rapid antigen test is very sensitive and specific for the detection of individuals who most probably are contagious.
Analytical performance of 17 commercially available point-of-care tests for CRP to support patient management at lower levels of the health system
Authors: Calarco Serafina , Fernandez-Carballo B. Leticia , Keller Thomas , Weber Stephan , Jakobi Meike , Marsall Patrick , Schneiderhan-Marra Nicole , Dittrich Sabine 
Published: April 2022

AbstractAccurate and precise point-of-care (POC) testing for C-reactive protein (CRP) can help support healthcare providers in the clinical management of patients. Here, we compared the analytical performance of 17 commercially available POC CRP tests to enable more decentralized use of the tool. The following CRP tests were evaluated. Eight quantitative tests: QuikRead go (Aidian), INCLIX (Sugentech), Spinit (Biosurfit), LS4000 (Lansionbio), GS 1200 (Gensure Biotech), Standard F200 (SD Biosensor), Epithod 616 (DxGen), IFP-3000 (Xincheng Biological); and nine semi-quantitative tests: Actim CRP (ACTIM), NADAL Dipstick (nal von minden), NADAL cassette (nal von minden), ALLTEST Dipstick (Hangzhou Alltest Biotech), ALLTEST Cassette cut-off 10-40-80 (Hangzhou Alltest Biotech), ALLTEST Cassette cut-off 10-30 (Hangzhou Alltest Biotech), Biotest (Hangzhou Biotest Biotech), BTNX Quad Line (BTNX), BTNX Tri Line (BTNX). Stored samples (n=660) had previously been tested for CRP using Cobas 8000 Modular analyzer (Roche Diagnostics International AG, Rotkreuz, Switzerland (reference standards). CRP values represented the clinically relevant range (10-100 mg/L) and were grouped into four categories (<10 mg/L, 10–40 mg/L or 10-30 mg/L, 40–80 mg/L or 30-80 mg/L, and > 80mg/L) for majority of the semi-quantitative tests. Among the eight quantitative POC tests evaluated, QuikRead go and Spinit exhibited better agreement with the reference method, showing slopes of 0.963 and 0.921, respectively. Semi-quantitative tests with the four categories showed a poor percentage agreement for the intermediate categories and higher percentage agreement for the lower and upper limit categories. Analytical performance varied considerably for the semi-quantitative tests, especially among the different categories of CRP values. Our findings suggest that quantitative tests might represent the best choice for a variety of use cases, as they can be used across a broad range of CRP categories.
Non-pharmacological measures for the treatment of iron deficiency anemia: A systematic review and meta-analysis
Authors: Brasileiro Gomes Francisca Mayara , Nogueira Arcanjo Francisco Plácido , Fonteles Moreira Francisco Leandro , Holanda Cunha Barreto Ivana Cristina de , de Andrade Luiz Odorico Monteiro , de Oliveira Thiago Corrêa , Vellozo Eliana Pereira , Kopelman Benjamin Israel , Arcanjo Freire Cecília Costa , Costa Arcanjo Caio Plácido , Zanetti Passos Maria Aparecida 
Published: April 2022

AbstractObjectiveTo conduct a systematic review and meta-analysis to evaluate the effectiveness of non-pharmacological measures for the treatment of iron-deficiency anemia (IDA).Data sourcesMEDLINE (via PubMed), Cochrane library, SciELO/LILACS and EMBASE up to June 2021Study selection and data extractionWe identified all randomized controlled trials (RCTs) that used non-pharmacological measures to treat IDA including iron pots/ingots, or food use were included. The outcomes of interest were hemoglobin (Hb) concentrations and prevalence of anemia.Results479 studies were retrieved from the databases, of which 4 duplicate records were removed. After, all titles and abstracts were reviewed, 23 articles were considered potentially relevant, and were read in full and checked for eligibility. Three articles met all inclusion criteria. We also conducted a manual search for citations and a further 8 records were identified and checked for eligibility. Eleven RCTs were included in this review. Estimates showed that the use of non-pharmacological measures was associated with a statistically significant overall increase in mean Hb (MD +0.45 g/dL, 95% CI 0.05 to 0.85, p=0.03). The effect of non-pharmacological measures on the prevalence of IDA was analyzed in only 5 RCTs. Participants in the intervention groups were 2.78 times less likely to suffer from IDA than those in the control groups, OR=2.78, 95% CI 0.93, 8.29, however without significance for the overall effect (p=0.07).ConclusionNon-pharmacological therapies have a positive effect on iron balance, and can a useful adjunct to programs to prevent and treat IDA in at-risk populations. (PROSPERO registration number CRD42021261773).
Uncovering the linguistic characteristics of psychotherapy: a computational approach to measure therapist language timing, responsiveness, and consistency
Authors: Miner Adam S , Fleming Scott L , Haque Albert , Fries Jason A , Althoff Tim , Wilfley Denise E , Agras W. Stewart , Milstein Arnold , Hancock Jeff , Ash Steven M , Stirman Shannon Wiltsey , Arnow Bruce A. , Shah Nigam H. 
Published: April 2022

AbstractAlthough individual psychotherapy is generally effective for a range of mental health conditions, little is known about the moment-to-moment language use of effective therapists. Increased access to computational power, coupled with a rise in computer-mediated communication (telehealth), makes feasible the large-scale analyses of language use during psychotherapy. Transparent methodological approaches are lacking, however. Here we present novel methods to increase the efficiency of efforts to examine language use in psychotherapy. We evaluate three important aspects of therapist language use - timing, responsiveness, and consistency - across five clinically relevant language domains: pronouns, time orientation, emotional polarity, therapist tactics, and paralinguistic style. We find therapist language is dynamic within sessions, responds to patient language, and relates to patient symptom diagnosis but not symptom severity. Our results demonstrate that analyzing therapist language at scale is feasible and may help answer longstanding questions about specific behaviors of effective therapists.
Using genotyping and whole-exome sequencing data to improve genetic risk prediction in deep venous thrombosis
Authors: Lo Faro Valeria , Johansson Therese , Höglund Julia , Hadizadeh Fatemeh , Johansson Åsa 
Published: April 2022

ABSTRACTBackgroundDeep Vein Thrombosis (DVT) is a common disease that can lead to serious complications such as pulmonary embolism and in-hospital mortality. More than 60% of DVT risk is influenced by genetic factors, such as Factor V Leiden (FVL) and prothrombin G20210A mutations (PTM). Characterising the genetic contribution and stratifying participants based on their genetic makeup can favourably impact risk prediction. Therefore, we aimed to develop and evaluate a genetic-based prediction model for DVT based on polygenic risk score (PRS) in the UK Biobank cohort.MethodsWe performed a genome-wide association study (GWAS) and constructed a PRS in the 60% (N=284,591) of the UK Biobank cohort. The remaining 40% (N=147,164) was employed to evaluate the PRS and to perform gene-based tests on exome-sequencing data to identify effects by rare variants.ResultsIn the GWAS, we discovered and replicated a novel variant (rs11604583) near TRIM51 gene and in the exome-sequencing data, and we identified a novel rare variant (rs187725533) located near CREB3L1, associated with 2.2-fold higher risk of DVT. In our PRS model, the top decile is associated with 3.4-fold increased risk of DVT, an effect that is 2.3-fold, when excluding FVL carriers. In the top PRS decile, cumulative risk of DVT at age of 80 years is 10% for FVL carriers, contraposed to 5% for FVL non-carriers.ConclusionWe showed that common and rare variants influence DVT risk and that the PRS improves risk prediction on top of FVL. This suggests that individuals classified with high PRS scores could benefit from early genetic screening.
Do panic values cause panic? Reporting of critical laboratory results in a tertiary hospital in Kenya
Authors: Mwogi Thomas , Mercer Tim , (Tina) Tran Dan N. , Tonui Ronald , Tylleskar Thorkild , Were Martin C. 
Published: April 2022

AbstractPrompt communication of critical laboratory results is important for patient safety. Various standardisation bodies have proposed procedures for handling critical results, with notification parameters outlined. However, few studies exist in low- and middle-income countries (LMIC) to document how critical results are handled. We tracked 12 types of laboratory tests over a three-week period in December 2018 and documented if and how critical test results were communicated, the time-frame for communication, and evidence of action taken on the results. During the period, 331 of 5,500 (6.1%) test results were identified as critical. Only 71 (21%) of the critical results were documented as having been communicated to the destination departments. Of the communicated results, clinicians were unaware of 21 (29.6%). Of the 12 test types, critical results were only communicated for three tests namely: potassium, haemoglobin and positive malaria tests. Communication of critical results to inpatient settings was significantly higher than to outpatient settings (p <0.05), with communication rates decreasing as the week progressed, during weekends and around holidays. The observed poor communication of critical results in an LMIC setting raise significant patient safety concerns. Laboratories in these settings need to adhere to international standards, like ISO 15189:2009, to assure safe practice. Training of staff, establishment of standard operating procedures guiding these results, and implementation of fail-proof critical result dissemination mechanisms are essential. It is important that all critical results are communicated within one hour of availability. Implementation of Order Entry and Laboratory systems should be highly considered.
Blood-brain barrier dysfunction promotes astrocyte senescence through albumin-induced TGFβ signaling activation
Authors: Preininger Marcela K. , Zaytseva Dasha , Lin Jessica May , Kaufer Daniela 
Published: April 2022

AbstractBlood-brain barrier dysfunction (BBBD) and accumulation of senescent astrocytes occur during brain aging and contribute to neuroinflammation and disease. Here, we explored the relationship between these two age-related events, hypothesizing that chronic hippocampal exposure to the blood-borne protein serum albumin could induce stress-induced premature senescence (SIPS) in astrocytes via transforming growth factor beta 1 (TGFβ) signaling. We found that one week of albumin exposure significantly increased TGFβ1 and senescence marker expression in cultured rat hippocampal astrocytes. These changes were preventable by pharmacological inhibition of the type I TGFβ receptor (TGFβR) ALK5. To study these effects in vivo, we utilized an animal model of BBBD in which albumin was continuously infused into the lateral ventricles of adult mice. Consistent with our in vitro results, one week of albumin infusion significantly increased TGFβ signaling activation and the burden of senescent astrocytes in hippocampal tissue. Pharmacological inhibition of TGFβR ALK5 or conditional genetic knockdown of astrocytic TGFβR prior to albumin infusion was sufficient to prevent albumin-induced astrocyte senescence. Together, these results establish a link between TGFβ signaling activation and astrocyte senescence and suggest that prolonged exposure to serum albumin due to BBBD can trigger these phenotypic changes.
Feasibility of an online antigen self-testing strategy for SARS-CoV-2 addressed to health care and education professionals in Catalonia (Spain). The TESTA’T-COVID Project
Authors: Agustí Cristina , Martínez-Riveros Héctor , González Victoria , Fernández-Rivas Gema , Díaz Yesika , Montoro-Fernandez Marcos , Moreno-Fornés Sergio , Romano-deGea Pol , Muntada Esteve , Calvo Beatriz , Casabona Jordi 
Published: April 2022

AbstractWe aimed to implement a pilot intervention based on offering online COVID-19 selftest kits addressed to healthcare and education professionals in Spain during the peak of the 6th wave caused by Omicron variant. Kits were ordered online and sent by mail, participants answered an online acceptability/usability survey and uploaded the picture of results. 492 participants ordered a test, 304 uploaded the picture (61.8%). Eighteen positive cases were detected (5.9%). 92.2% were satisfied/very satisfied with the intervention; and 92.5% found performing the test easy/very easy. We demonstrated that implementing online COVID-19 self-testing in schools and healthcare settings in Spain is feasible.Key findingsWe implemented a pilot intervention based on offering online COVID-19 selftest kits in Spain.We demonstrated the feasibility of the intervention during the peak of the 6th wave caused by Omicron variant.The intervention counted with high acceptability among healthcare and education professionals in Spain.Our results may contribute to define screening strategies addressed to key populations, particularly during peaks of high community transmission of SARS-CoV-2.
Immediate, remote smoking cessation intervention in participants undergoing a targeted lung health check: QuLIT2 a randomised controlled trial
Authors: Williams Parris J , Philip Keir EJ , Gill Navjot Kaur , Flannery Deirdre , Buttery Sara , Bartlett Emily C , Devaraj Anand , Kemp Samuel V , Addis Jamie , Derbyshire Jane , Chen Michelle , Morris Katie , Laverty Anthony A. , Hopkinson Nicholas S 
Published: April 2022

AbstractBackgroundLung cancer screening programs provide an opportunity to support smokers to quit, but the most appropriate model for delivery remains to be determined. Immediate face to face smoking cessation support for people undergoing screening can increase quit rates, but it is not known whether remote delivery of immediate smoking cessation counselling and pharmacotherapy in this context is also effective.Materials and MethodsIn a single-blind randomised controlled trial, smokers aged 55-75 years attending a Targeted Lung Health Check (TLHC) were allocated by day of attendance to receive either immediate telephone smoking cessation support (TSI) (starting immediately and lasting for 6 weeks) with appropriate pharmacotherapy, or usual care (very brief advice to quit and signposting to smoking cessation services) (UC). The primary outcome was self-reported 7-day point prevalence smoking abstinence at three months. Differences between groups were assessed using logistic regression.Results315 current smokers taking part in the screening programme, mean (SD) age 63(5.4) years, 48% female, were randomised to telephone smoking cessation (n=152) or usual care (n=163). The two groups were well-matched at baseline. Self-reported quit rates were higher in the intervention arm, 21.1% vs 8.9% (odds ratio [OR]: 2.83, 95% CI 1.44-5.61, p=0.002). Controlling for participant demographics, baseline smoking characteristics or the discovery of abnormalities on low dose CT scanning did not modify the effect of the intervention.ConclusionImmediate provision of an intensive telephone-based smoking cessation intervention, delivered within a targeted lung screening context, is associated with increased smoking abstinence at three months.Trial registrationThis study is registered online: ISRCTN12455871.Take home messageProviding immediate, telephone smoking cessation support with pharmacotherapy to smokers enrolled in a TLHC program increases quit rates in this population by almost a third.