bluuebunny/crossref_metadata_2025_split huggingface dataset:
Durable response to afatinib rechallenge in a long‐term survivor of non‐small cell lung cancer harboring EGFR L858R and L747V mutations
Authors: Kanbe Mio , Sunaga Noriaki , Hara Kenichiro , Sawada Hiiru , Wakamatsu Ikuo , Hara Kentaro , Muto Sohei , Sawada Yuri , Masubuchi Hiroaki , Sato Mari , Miura Yosuke , Tsurumaki Hiroaki , Yatomi Masakiyo , Sakurai Reiko , Koga Yasuhiko , Ohtaki Yoichi , Nagashima Toshiteru , Okano Naoko , Kubo Nobuteru , Maeno Toshitaka , Hisada Takeshi 
Published: October 2022

AbstractEpidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitors are standard therapeutic agents for non‐small cell lung cancer (NSCLC) patients with major EGFR mutations such as exon 19 deletions and a L858R mutation, whereas treatment strategies for cases with uncommon EGFR mutations remain to be fully established. Here, we report a long‐term (≥20 years from initial diagnosis) NSCLC survivor carrying EGFR L858R and L747V mutations. The patient received gefitinib monotherapy, systemic chemotherapy/chemoimmunotherapy, and local consolidative therapies for oligometastatic lesions, and responded to afatinib rechallenge with a progression‐free survival of 12 months. The current case suggests that afatinib is effective in NSCLC patients with EGFR L858R and L747V mutations and that a therapeutic approach combining appropriately timed systemic therapies with local consolidative therapies for oligometastatic lesions improves long‐term survival.
Cocaine falls into oblivion during volitional initiation of choice trials
Authors: Vandaele Youna , Augier Eric , Vouillac‐Mendoza Caroline , Ahmed Serge H. 
Published: October 2022

AbstractWhen facing a choice, most animals quit drugs in favour of a variety of nondrug alternatives. We recently found, rather unexpectedly, that choice of the nondrug alternative is in fact inflexible and habitual. One possible contributing factor to habitual choice is the intermittency and uncontrollability of choice trials in previous studies. Here, we asked whether and to what extent volitional control over the occurrence of choice trials could change animals' preference by preventing habitual choice. To do so, rats were trained to nosepoke in a hole to trigger the presentation of two operant levers: one associated with cocaine, the other with saccharin. Rats were then free to choose among the two levers to obtain the corresponding reward, after which both levers retracted until rats self‐initiated the next choice trial. Overall, we found that volitional control over choice trials did not change preference. Most rats preferred saccharin over cocaine and selected this option almost exclusively. Intriguingly, after repeated choice and consumption of saccharin, rats transiently lost interest in this option (i.e., due to sensory‐specific satiety), but they did not switch to cocaine, preferring instead to pause during long periods of time before reinitiating a choice trial for saccharin. This finding suggests that during volitional initiation of a choice trial, rats fail to consider cocaine as an option. We discuss a possible associative mechanism to explain this perplexing behaviour.
The early diversification of ray‐finned fishes (Actinopterygii): hypotheses, challenges and future prospects
Authors: Henderson Struan , Dunne Emma M. , Fasey Sophie A. , Giles Sam 
Published: October 2022

ABSTRACTActinopterygii makes up half of living vertebrate diversity, and study of fossil members during their Palaeozoic rise to dominance has a long history of descriptive work. Although research interest into Palaeozoic actinopterygians has increased in recent years, broader patterns of diversity and diversity dynamics remain critically understudied. Past studies have investigated macroevolutionary trends in Palaeozoic actinopterygians in a piecemeal fashion, variably using existing compendia of vertebrates or literature‐based searches. Here, we present a comprehensive occurrence‐based dataset of actinopterygians spanning the whole of the Palaeozoic. We use this to produce the first through‐Palaeozoic trends in genus and species counts for Actinopterygii. Diversity through time generally tracks metrics for sampling, while major taxonomic problems pervading the Palaeozoic actinopterygian record obscure diversity trends. Many described species are concentrated in several particularly problematic ‘waste‐basket’ genera, hiding considerable morphological and taxonomic diversity. This taxonomic confusion also feeds into a limited understanding of phylogenetic relationships. A heavy sampling bias towards Europe and North America exists in both occurrence databases and available phylogenetic matrices, with other regions underrepresented despite yielding important data. Scrutiny of the extent to which spatial biases influence the actinopterygian record is lacking, as is research on other forms of bias. Low richness in some time periods may be linked to geological biases, while the effects of taphonomic biases on Palaeozoic actinopterygians have not yet been investigated. Efforts are already underway both to redescribe poorly defined taxa and to describe taxa from underrepresented regions, helping to address taxonomic issues and accuracy of occurrence data. New methods of sampling standardisation utilising up‐to‐date occurrence databases will be critical in teasing apart biological changes in diversity and those resulting from bias. Lastly, continued phylogenetic work will enable the use of phylogenetic comparative methods to elucidate the origins of actinopterygian biogeography and subsequent patterns of radiation throughout their rise to dominate aquatic faunas.
Securing permanence for children in care: A cross‐country analysis of citizen's view on adoption versus foster care
Authors: Skivenes Marit , Benbenishty Rami 
Published: October 2022

AbstractIf children in child protection cannot be cared for by their natural parents, should they be adopted or live in foster home? Results from a study of representative samples of populations (n = 12 330), in eight European countries—Austria, England, Estonia, Finland, Germany, Ireland, Norway and Spain—and California, USA, reveal that people would recommend adoption over foster care, if a child in public care cannot grow up with their natural parent(s). There are cross‐country differences between populations, and examining if institutional context such as type of child protection system explains differences, we find that child maltreatment‐oriented systems are more supportive of adoption than other types of systems. Citizens having little confidence in the child protection system were only weakly correlated with preference for adoption. In conclusion, people prefer adoption as placement options for children in care are more than foster homes, and possible this finding reflects a sort of refamalialization of children into the private sphere.
Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases
Authors: Chen Zhenlei , Yuan Ziqi , Yang Shangchen , Zhu Yufei , Xue Maoqiang , Zhang Jie , Leng Lige 
Published: October 2022

AbstractAstrocytes are the most abundant cells in the brain. They have many important functions in the central nervous system (CNS), including the maintenance of glutamate and ion homeostasis, the elimination of oxidative stress, energy storage in glycogen, tissue repair, regulating synaptic activity by releasing neurotransmitters, and participating in synaptic formation. Astrocytes have special highly ramified structure. Their branches contact with synapses of neurons inwardly, with fine structure and wrapping synapses; their feet contact with blood vessels of brain parenchyma outward, almost wrapping the whole brain. The adjacent astrocytes rarely overlap and communicate with each other through gap junction channels. The ideal location of astrocytes enables them to sense the weak changes of their surroundings and provide the structural basis for the energy supply of neurons. Neurons and astrocytes are closely coupled units of energy metabolism in the brain. Neurons consume a lot of ATPs in the process of neurotransmission. Astrocytes provide metabolic substrates for neurons, maintain high activity of neuron, and facilitate information transmission of neurons. This article reviews the characteristics of glucose metabolism, lipid metabolism, and amino acid metabolism of astrocytes. The metabolic interactions between astrocytes and neurons, astrocytes and microglia were also detailed discussed. Finally, we classified analyzed the role of metabolic disorder of astrocytes in the occurrence and development of neurodegenerative diseases.
Cannabis use for pain relief in the context of health service barriers: Accounts of street‐involved Nigerian women suffering chronic pain
Authors: Nelson Ediomo‐Ubong E. , Kitchen Chenai 
Published: October 2022

AbstractIntroductionThis study explored cannabis use for pain relief among socially marginalised Nigerian women in the context of barriers to pain management.MethodsThe study was designed as a qualitative exploratory study of pain experience and management. Sixteen in‐depth, individual interviews were conducted with street‐involved women who use drugs and had chronic pain. Transcripts were coded and analysed thematically.ResultsPain was experienced as a pervasive feature of everyday life that disrupted daily routines, affected economic activities, strained social relationships and had adverse effects on health and wellbeing. Participants sought treatment in health facilities, but faced social and health system barriers to service utilisation including financial cost of services, dismissal of symptoms by providers, stigma due to physical appearance, substance use and lack of social support. These barriers encouraged disengagement from services and reliance on cannabis (along with heroin and diverted prescription opioids) for pain management. Cannabis use relieved pain and improved daily functioning, enabling participants to undertake economic activities. However, using cannabis to enhance the effects of opioids and heavy and long‐term use owing to pain chronicity and disability generated concerns about harms.Discussion and ConclusionsFindings show the therapeutic benefits of cannabis in the face of barriers to pain management. This support calls to explore the potentials of cannabis for pain management for socially marginalised populations and to develop medical guidelines to reduce the risk of adverse health consequences. Therapeutic cannabis, provided based on medical guidance, could improve pain management for socially marginalised populations.
A gendered analysis of trends in the faith‐based provision of social services: Evidence from Egypt and Turkey
Authors: Çavdar Gamze 
Published: October 2022

AbstractThe involvement of faith‐based organizations in the provision of social welfare has been popular in discourse and policy over the last several decades. This policy is often recommended as a remedy to the underfunded and underdeveloped social welfare system in late industrializing countries. This paper aims to discuss the implications of this recommended policy on women in the MENA region. This question is significant because women in the MENA region need social services as they have the lowest labor market participation in the world and they have been disproportionately affected by poverty over the last decade, a trend exacerbated during the COVID‐19 pandemic. Based on fieldwork and utilizing both qualitative and quantitative sources, this paper discusses evidence from two country cases in the MENA region, Egypt and Turkey. The paper argues that the provision of social welfare by faith‐based organizations falls short in providing a substitute or alternative to publicly funded and universally provided social services for women because the provision of these services is inconsistent and unreliable and could be coopted by the government. Egypt represents a case in which the al‐Sisi regime adopted a confrontational strategy toward the Muslim Brotherhood and dismembered its services, while Turkey represents a case in which government coopts faith‐based organizations for political gain.
Implementation of occupational therapy within early intervention in psychosis services: Results from a national survey
Authors: Thomas Elizabeth C. , Read Halley , Neumann Nuriya , Zagorac Sarah , Taylor Caitlin , Kramer Ilyse , Fisher Ruth Marie , De Angelis Tina 
Published: October 2022

AbstractAimOccupational therapy plays an important role in fostering community participation in areas such as education, employment, leisure, and social relationships, yet its added value within early intervention in psychosis services, especially in the United States, remains poorly understood. The purpose of this research was to conduct a national survey of early intervention in psychosis programs to: (1) understand the role and unique contributions of occupational therapists to early intervention teams, and (2) identify barriers and supports to the implementation of occupational therapy services within these programs.MethodsFifty‐one senior leaders from U.S.‐based early intervention in psychosis programs participated in the national survey. The survey consisted of a series of closed and open‐ended questions related to program staffing, the presence of specific services that fall within the occupational therapy scope of practice, and implementation barriers and supports.ResultsDespite there being strong interest in employing occupational therapists, a small proportion of programs (31%) reported having them on staff. Occupational therapists supported clients across multiple life areas and were significantly more likely than other team members to promote daily living activities (e.g., cooking) and to address sensory processing needs and challenges. Implementation was influenced by environmental/organizational and staff factors; the primary barrier was funding.ConclusionsFindings support the role occupational therapists may play in facilitating the community participation of clients of early intervention services, but significant barriers to implementation of occupational therapy services remain. Additional research is needed to further identify the impact of occupational therapy services within the early intervention model.
Are genetic variation and demographic performance linked?
Authors: Carley Lauren N. , Morris William F. , Walsh Roberta , Riebe Donna , Mitchell‐Olds Tom 
Published: October 2022

AbstractQuantifying relationships between genetic variation and population viability is important from both basic biological and applied conservation perspectives, yet few populations have been monitored with both long‐term demographic and population genetics approaches. To empirically test whether and how genetic variation and population dynamics are related, we present one such paired approach. First, we use eight years of historical demographic data from five populations of Boechera fecunda (Brassicaceae), a rare, self‐compatible perennial plant endemic to Montana, USA, and use integral projection models to estimate the stochastic population growth rate (λS) and extinction risk of each population. We then combine these demographic estimates with previously published metrics of genetic variation in the same populations to test whether genetic diversity within populations is linked to demographic performance. Our results show that in this predominantly inbred species, standing genetic variation and demography are weakly positively correlated. However, the inbreeding coefficient was not strongly correlated with demographic performance, suggesting that more inbred populations are not necessarily less viable or at higher extinction risk than less inbred populations. A contemporary re‐census of these populations revealed that neither genetic nor demographic parameters were consistently strong predictors of current population density, although populations showing lower probabilities of extinction in demographic models had larger population sizes at present. In the absence of evidence for inbreeding depression decreasing population viability in this species, we recommend conservation of distinct, potentially locally adapted populations of B. fecunda rather than alternatives such as translocations or reintroductions.
Major league baseball and the exploitation of Latin American children: Confronting baseball's greatest sin
Authors: Shimshi Stephen 
Published: October 2022

AbstractOn April 1, 2021, Major League Baseball celebrated its 145th Opening Day. Across the 30 clubs, 256 players represented 20 different countries and territories outside of the United States. The 256 players accounted for 28.3% of total players on Opening Day rosters and inactive lists. This number of foreign‐born players marked the second highest all‐time total on Opening Day rosters for a full season. Like never before, baseball has become global. Fans are routinely enthralled by the passion and flare these players bring to the game, but few are aware of the childhood exploitation they must overcome along the way.
Leadership development, gender and race: Intersectional insights from South Africa
Authors: Lewis Clif P 
Published: October 2022

AbstractThis research explores the existence of differential group‐level experiences in a South African retail group's leadership development programme (LDP). Primary data were collected with semistructured intersectional focus groups. Findings were triangulated with secondary data from organizational document analysis. Emerging themes were identified with Thematic and Axial coding. Gender‐ and race identity shape how content, development needs, peer interactions, and support are experienced within the LDP. Additionally, certain findings also contradict existing knowledge of LDPs, such as the prevalence of mistrust between participants in a mixed‐group programme. Findings indicate a need for further research to explore the differential effects of intersectional identities on the experience of LDPs. Findings challenge psychologically and behaviourally focused conceptions of leadership development by demonstrating how multiple identities interdependently influence the experience of an LDP. Concurrently, the study challenges existing knowledge of group dynamics within mixed‐group development programmes by highlighting essentialist assumptions about gender and race in the context of leadership development. An analysis of the qualitative data also produced the counterintuitive finding that intersecting bases of privilege might actually result in negative outcomes within a learning context. Finally, the study also contributes to the body of knowledge of intersectionality by demonstrating its utility in leadership development research.
Ph5GT silencing alters flower color and flavonoids metabolome profile in petunia
Authors: Li Xin , Cao Jiahao , Zhao Huina , Jiang Guiyun , Liu Juanxu , Yu Yixun 
Published: October 2022

AbstractAnthocyanins are important pigments in plants and glycosylation plays an important role in the stability of anthocyanins. Anthocyanin 5‐O‐glucosyltransferase (5GT) can glycosylate anthocyanin at the 5‐O‐position. Till now, the enzymatic activity characteristics of 5GT had been studied in vitro in a variety of plants. However, the subcellular localization of 5GT protein still remained unclear, and little genetic evidence on the roles of 5GT in plants has been reported. The full‐length Ph5GT gene from petunia (Petunia hybrida) was isolated in this study. Green fluorescent fusion protein assays revealed that Ph5GT protein was localized to the cytoplasm. Ph5GT was found to be highly expressed in flowers, with highest levels of expression occurring during the coloring stage of flower development. Furthermore, Ph5GT silencing led to the change in flower color from purple to light purple and a significant reduction in total anthocyanin content. The metabolome analysis revealed that the content of malvidins and petunidins modified by glycosylation at the 5‐O‐position was significantly reduced, while the content of their precursor without glycosylation was significantly increased, implying that Ph5GT could glycosylate malvidin and petunidin derivatives and that the substrate types of Ph5GT were expanded in comparison to previous studies.
Optimal Approximate Choice Designs for a Two-step Coffee Choice, Taste and Choice Again Experiment
Authors: Nikiforova Nedka Dechkova , Berni Rossella , López-Fidalgo Jesús Fernando 
Published: October 2022

AbstractThis work deals with consumers' preferences about coffee. Firstly, a choice experiment is performed on a sample of potential consumers. Following this, a sensory test involving the tasting of two varieties of coffee is carried out with the respondents, after which the same choice experiment is supplied to them again. An innovative approach for building heterogeneous choice designs is specifically developed for the case-study, based on approximate design theory and compound design criterion. Panel Mixed Logit models are used, thereby allowing for the inclusion of correlation among consumers' responses; choice-sets are supplied to a proportion of respondents according to optimal weights. The estimation results of the Panel Mixed Logit model are satisfactory, confirming the validity of the proposed approach.
Special issue: Nationalism and the integration of migrant children
Authors: Gornik Barbara 
Published: October 2022

AbstractWhen it comes to academic debates about the integration of migrant children, the field is thoroughly heterogeneous in terms of the methods used and topics discussed. Research ranges from questions of belonging, acculturation, and hybrid identities to a focus on education, religion, family, well‐being and mental health, peer dynamics, integration support measures, nationalism, xenophobia, and discrimination. The initiative to publish a special issue on the integration of migrant children emerged from the project Migrant Children and Communities in a Transforming Europe (MiCREATE), a Horizon 2020 Research and Innovation Action, which aimed to identify effective child‐centred integration approaches for use in education and at the policy level across the European Union. The overarching goal of this special issue is to reflect on how nationalism manifests itself at different levels of social life and how it is reproduced in integration practices. The articles collected here examine how migrant children, education professionals, and policy‐makers understand, navigate, and experience the processes of integration, and how these processes are in turn influenced by discourses on nationalism and multiculturalism.
(Methodological) nationalism and academic debates on the integration of migrant children
Authors: Gornik Barbara 
Published: October 2022

AbstractThe article takes up current academic debates on the integration of migrant children and reflects on how they accommodate the discourse of nationalism; it discusses how nationalism functions as a practical category, as a classification scheme, and as a cognitive framework, as well as what counter‐hegemonic views can be found in the existing scholarship. The article shows that academic debates about the integration of migrant children are firmly situated on the conceptual map of nationalism, but navigate this field in different ways. Principally, these debates 1) maintain migrant identity as the main analytical category; 2) focus on the gap exhibited by migrant children in various aspects where non‐migrant children are used as the standard of ‘normality’; 3) view ethnic diversity as a ‘problem’ and therefore approach it as something ‘pathological’; and 4) examine migrant children in relation to nationalizing practices that touch on issues of identity, language, community, and belonging; yet also 5) offer critical counter‐hegemonic views concerning the integration of migrant children and deconstruct the power relations and commonly held classification schemes within the discourse of nationalism.