bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecule transfer mechanism in two‐dimensional heterostructured lamellar membranes: The effects of dissolution and diffusion
Authors: Chen Chongchong , Wu Xiaoli , Zhang Jie , Chen Jingjing , Cui Xulin , Li Wenpeng , Wu Wenjia , Wang Jingtao 
Published: June 2022

AbstractTwo‐dimensional lamellar membranes are promising for efficient molecule transfer, while the underlying transfer mechanism is rarely elucidated. Herein, heterostructured nanosheets are prepared by self‐assembling small‐sized hydrophilic cyanuric acid melamine and hydrophobic g‐C3N4 nanosheets. Resultant lamellar membranes show comparable affinity to polar and nonpolar solvents, allowing them to dissolve on membrane surface and diffuse through membrane channels. Results demonstrate that for lamellar membranes with distinct wettability, the permeance difference for polar solvents is originated from dissolution and diffusion processes, while that for nonpolar solvents is stemmed from dissolution process. Accordingly, corresponding equations which are suitable for heterostructured lamellar membranes are established. Importantly, polar solvents are induced to form ordered arrangement in hydrophilic nanodomains and then maintain the ordered state in hydrophobic nanodomains, affording a low‐resistance transfer and high acetonitrile permeance of 1025 L m−2 h−1 bar−1. In contrast, nonpolar solvents with disordered arrangement exhibit lower permeance than that of polar ones.
Synthesis of pyrido[2,3‐d:5,6‐d′]dipyrimidines using CuFe2O4/KCC‐1/PMA as a novel and efficient nanocatalyst under solvent‐free conditions
Authors: Sadeghi Seyyed Hojjat , Yaghoobi Morteza , Ghasemzadeh Mohammad Ali 
Published: June 2022

AbstractIn this research, the synthesis of pyrido[2,3‐d:5,6‐d′]dipyrimidines by CuFe2O4/KCC‐1/PMA magnetic nanoparticles was reported. Synthesis of pyrido[2,3‐d:5,6‐d′]dipyrimidines was performed under solvent‐free conditions with good to excellent yields. The prepared nanocatalyst was synthesized in three steps and also was characterized by Fourier transform infrared (FT‐IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy‐dispersive X‐ray spectroscopy (EDX), X‐ray diffraction (XRD), vibrating sample magnetometry (VSM), and N2 adsorption–desorption measurement (Brunauer–Emmett–Teller [BET]) analyses. In addition, the reusability studies of CuFe2O4/KCC‐1/PMA showed that the recovered catalyst could be used for several times.
Isoconversional models toward the curing kinetics of self‐healable epoxy resin TGDDM and acid anhydride
Authors: Ma Zhihang , Wang Xiao , Li Junru , Li Xinlin , Zhang Chuanwei , Zhang Ruyi , Gu Yan , Zhang Pengfei 
Published: June 2022

AbstractThe reaction process and curing mechanism of self‐healable epoxy resin TGDDM and curing agent TA are complicated. In this paper, the curing reaction kinetic mechanism of the system is studied from the perspective of isoconversional models. The nth‐order model and autocatalysis model are established for observations of heat flow versus temperature and time during real‐time curing obtained by non‐isothermal differential scanning calorimetry (DSC), and evaluated under the standards of MSE, RMSE, and R‐square. Under the guidance of least squares fitting, the pre‐exponential factor (A), the activation energy (), the order of models (n, m) and other parameters in of the model are mainly estimated by Kissinger method, Ozawa method, Malek method, and other methods. The correlation between the activation energy () of the reaction and the degree of conversion also analyzed by the Flynn‐Wall‐Ozawa method. The chemical reaction of the system is studied by Fourier transform infrared (FTIR) and the self‐healing property of the system is characterized by scanning electron microscope (SEM). It was found that the esterification reaction occurred in the system, and the realization of the self‐healing property was also due to the transesterification reaction. In addition, the effect of the accelerator on the system is analyzed by the established autocatalysis model and dynamic mechanical analysis (DMA). The result shows that the addition of the accelerator does not change the curing reaction mechanism of the system, but accelerated the reaction process and increased the glass transition temperature.
Differential influence of YAP1 and TAZ on differentiation of intestinal epithelial cell: A review
Authors: Fallah Sepideh , Beaulieu Jean‐François 
Published: June 2022

AbstractIntestinal cell stemness, proliferation and differentiation are complex processes all occurring in distinct compartments of the crypt that need to be closely regulated to ensure proper epithelial renewal. The involvement of the Hippo pathway in intestinal epithelial proliferation and regeneration after injury via the regulation of its effectors YAP1 and TAZ has been well‐documented over the last decade. The implication of YAP1 and TAZ on intestinal epithelial cell differentiation is less clear. Using intestinal cell models in which the expression of YAP1 and TAZ can be modulated, our group showed that YAP1 inhibits differentiation of the two main intestinal epithelial cell types, goblet and absorptive cells through a specific mechanism involving the repression of prodifferentiation transcription factor CDX2 expression. Further analysis provided evidence that the repressive effect of YAP1 on intestinal differentiation is mediated by regulation of the Hippo pathway by Src family kinase activity. Interestingly, the TAZ paralog does not seem to be involved in this process, which provides another example of the lack of perfect complementarity of the two main Hippo effectors.
Supramolecular Ensembles Formed via Calix[5]arene‐Fullerene Host‐Guest Interactions
Authors: Hirao Takehiro , Haino Takeharu 
Published: June 2022

AbstractThis Review introduces the research directions for the synthesis of supramolecular fullerene polymers. First, the discovery of host‐guest complexes of pristine fullerenes is briefly outlined. We focus on progress in supramolecular fullerene polymers directed by the use of calix[5]arene‐fullerene interactions, which comprise linear, networked, helical arrays of fullerenes in supramolecular ensembles. The unique self‐sorting behavior of right‐handed and left‐handed helical supramolecular fullerene arrays is discussed. Thereafter, an extensive investigation of the calix[5]arene‐fullerene interaction for control over the chain structures of covalent polymers is introduced.
Changes in water demand resulting from pandemic mitigations in Southeast Michigan
Authors: Fritsche Jessica R. , Whitby Patricia , Griffin Eric , Norton John W. , Alfahham Nuha , Kuhns Timothy , Bell Katherine Y. 
Published: June 2022

AbstractThe COVID‐19 pandemic impacted many dimensions of daily life; including how and where people used water. These changes have important implications for water management and utility planning. This study quantifies regional water demand changes across 75 utilities in Southeast Michigan throughout 2020. Deviations were not uniform, with both increases and decreases noted in indoor base flow and average day demands. Effects on diurnal patterns included peak use decreasing but occurring later in the morning and lasting longer. Utility demand changes are statistically correlated to community characteristics of income, population density, job density, and daytime population as well as altered movement trends in response to shutdowns. Commuter communities and those with employment centers experienced greater demand deviations. Understanding the socio‐demographic factors behind the changes will help determine which patterns will be permanent or prevail post‐pandemic. Utilities will be able to better plan for water supplies, capital improvements, operations, and finances.
Identifying critical success factors for the agri‐food cold chain's sustainable development: When the strategy system comes into play
Authors: Su Miao , Woo Su‐Han , Chen Xiaochun , Park Keun‐sik 
Published: June 2022

AbstractWith serious environmental, cost, and social concerns arising from emerging countries' rapid growth in agricultural food cold chain (AFCC), AFCC firms urgently require a set of comprehensive sustainable strategic solutions. Therefore, this research identified and modeled the critical success factors (CSFs) that support the sustainable development of AFCCs. The study integrated institutional theory, stakeholder theory, and the triple bottom line model; it also surveyed cold chain experts from 16 different organizations in China and applied the adversarial interpretation structure model (AISM). This comprehensive analysis indicates that managing stakeholder pressure is the most motivating CSF of all strategies. This strategy eventually contributes to the sustainability of AFCC in China by driving other CSFs. Additionally, the study determined the degree of interdependence and dominance of different strategies. Thus, this study establishes a theoretical foundation for the sustainable improvement of AFCC organizations' business strategies and environmental policies.
Pan‐cancer analysis identifies CD300 molecules as potential immune regulators and promising therapeutic targets in acute myeloid leukemia
Authors: Xu Zi‐jun , Jin Ye , Zhang Xin‐long , Xia Pei‐hui , Wen Xiang‐mei , Ma Ji‐chun , Lin Jiang , Qian Jun 
Published: June 2022

AbstractBackgroundCD300s are a group of proteins playing vital roles in immune responses. However, much is yet to be elucidated regarding the expression patterns and clinical significances of CD300s in cancers.MethodsIn this study, we comprehensively investigated CD300s in a pan‐cancer manner using multi‐omic data from The Cancer Genome Atlas. We also studied the relationship between CD300s and the immune landscape of AML.ResultsWe found that CD300A‐CD300LF were generally overexpressed in tumors (especially AML), whereas CD300LG was more often downregulated. In AML, transactivation of CD300A was not mediated by genetic alterations but by histone modification. Survival analyses revealed that high CD300A‐CD300LF expression predicted poor outcome in AML patients; the prognostic value of CD300A was validated in seven independent datasets and a meta dataset including 1115 AML patients. Furthermore, we demonstrated that CD300A expression could add prognostic value in refining existing risk models in AML. Importantly, CD300A‐CD300LF expression was closely associated with T‐cell dysfunction score and could predict response to AML immunotherapy. Also, CD300A was found to be positively associated with HLA genes and critical immune checkpoints in AML, such as VISTA, CD86, CD200R1, Tim‐3, and the LILRB family genes.ConclusionsOur study demonstrated CD300s as potential prognostic biomarker and an ideal immunotherapy target in AML, which warrants future functional and clinical studies.
Localized CO2 laser treatment of a recalcitrant oral ulceration in pemphigus vulgaris
Authors: Chainani‐Wu Nita , Gopal‐Murthy Vinitha , Wu Aadi , Marinkovich M. Peter 
Published: June 2022

AbstractIntroductionRecalcitrant oral lesions of pemphigus vulgaris (PV), an autoimmune blistering disease, can result in significant discomfort, difficulty in eating, and maintaining oral hygiene. Increasing the dosage of systemic medications to control such localized lesions results in an increased risk of adverse effects.Case PresentationWe describe a male patient diagnosed at age 51 with PV by oral biopsy that included a direct immunofluorescence examination. After further baseline laboratory testing, he was started on prednisone and mycophenolate. These medications were slowly tapered with adjustments guided by clinical signs. Mycophenolate was replaced with intravenous immunoglobulin monthly infusions due to adverse effects about 2 years after initiation. During the 4.5‐year follow‐up period after diagnosis, his oral and skin lesions were well‐controlled apart from minor transient flares. However, a painful ulcerated lesion on the facial gingiva between #11 and 12 was nonresponsive, even with the use of topical clobetasol in trays. A carbon dioxide (CO2) laser was used to vaporize the recalcitrant lesion under local anesthesia. The procedure resulted in complete healing of ulceration with no recurrence until the most recent examination, 2 years postlaser surgery.ConclusionAdjunctive procedures that can facilitate a decrease in the cumulative dosage of corticosteroids and immunosuppressants have great value in the management of PV. CO2 laser vaporization is safe, with minimal morbidity and no long‐term side effects. It should be considered an adjunctive treatment option for the management of recalcitrant lesions in patients with oral PV.Key pointsWhy is this case new information?

To our knowledge, this is the second report on the use of a CO2 laser in the treatment of recalcitrant oral lesions of PV and the first report with a documented long‐term resolution of the treated lesions.
What are the keys to the successful management of this case?

A localized recalcitrant lesion was treated with this approach. All other mucosal and cutaneous sites were well controlled on the patient's systemic medication regimen.
What are the primary limitations to success in this case?

This approach is only relevant for the management of recalcitrant lesions in patients whose disease activity is otherwise well controlled. The availability of specialized equipment and trained clinicians is necessary.
Intelligent recognition of portrait sketch components for child autism assessment
Authors: Shen Yang , Wang Xinyu , Chen Zhangmeng , Sun Qi , Zhang Xu , Liang Hui , Pan Junjun 
Published: June 2022

AbstractFor autistic children with slow language function, it is a classic and easy way to understand the development of their cognitive ability through simple painting experiments. Due to the lack of professional evaluators for painting assessment of autistic children, this article research and implement an intelligent assessment system for child autism through recognition of portrait sketch components. A portrait sketch database is constructed with the sample size of 30,400 after data expansion. The data consists of two formats: stroke vector sequence and 2D image. Then we propose a joint model coupled with LSTM and CNN features to automatically segment the portrait sketch components. It can perform better segmentation for exaggerated proportion and incomplete components samples. Finally, according to the evaluation criteria of the painting, we design an assessment model for child autism. The experiments are conducted in cooperation with relevant rehabilitation institutions to verify the effectiveness of the system. The analysis results show that our painting assessment system has a good ability to identify autistic tendencies. It can accurately evaluate children's autistic tendencies through “draw‐a‐man” experiments.
Thermal conductivity of salvaged fused cast alumina used in the glass industry
Authors: Wang Hsin , Hemrick James G. 
Published: June 2022

AbstractFused cast alumina (FCA) has been and continues to be used as a refractory material in energy intensive industries such as glass melting and chemical processing. In‐service degradation due to high temperature exposure in harsh environment affects the designed furnace thermal profiles and energy consumption. Phase transformation may occur at the refractory hot face during glass melting altering the properties. Three FCA blocks recovered from industrial furnaces were investigated in this study. The as‐received FCA consists primarily of a mixture of alpha (α) and beta (β) alumina that has a thermal conductivity value of 5–6 W/mK. The Hot Disk method was used to obtain thermal conductivity directly on the refractory blocks. At the hot face, a transformation from β to α alumina occurred and was confirmed by an X‐ray diffraction study. Thermal conductivity measurements as a function of position also showed a clear transition from β to α alumina at both ends of a complete block with no voids. Thermal conductivity of the α alumina tripled compared to β alumina. This study provides important information of heat transfer and thermal conductivity evolution to refractory manufacturers and users.
Hochdruck‐geeignete AM‐Konstruktionselemente mit hierarchisch‐funktionalen Metallstrukturen
Authors: Kiener Christoph , Boschert Stefan , Küsters Yves , Nicolai Alexander , Otto Robert 
Published: June 2022

AbstractUnter den Methoden der additiven Fertigung (AM) bietet insbesondere das Metallpulverbett‐Laserstrahlschmelzen PBF‐LB/M die Möglichkeit, Bauteile für die Prozessverfahrenstechnik mit funktionalen Strukturen auszustatten: Aus dem digitalen 3D‐Modell entsteht direkt, ohne Einsatz mechanischer Werkzeuge, ein Bauteil mit mehreren funktionalen Kompartimenten. Dabei kann die prozesstechnische Funktionalität über mehrere geometrische Hierarchien („von 50 µm bis 50 cm”) gezielt adressiert und ortsaufgelöst in korrosions‐ und temperaturresistenten, hochdruckgeeigneten Legierungen gefertigt werden.
Zeitenwende in der Wirtschaft
Authors: Meyer Jens‐Uwe 
Published: June 2022

AbstractUkrainekrieg, Corona, Klimawandel, Lieferkettenprobleme – was viele Unternehmen aktuell erleben, ist eine Zeitenwende. Sie müssen ihre Geschäftsmodelle radikal überdenken und zum Teil neu erfinden, denn: Viele alte Wahrheiten gelten nicht mehr. Es bedarf eines “Reset” bzw. Neustarts auf allen Ebenen.
Bionische Optimierung im Druckbehälterbau
Authors: Becker Daniel , Gerling Sina , Kockmann Norbert 
Published: June 2022

AbstractBei der mechanischen Auslegung von chemischen Prozessapparaten sind bionische Leichtbaumethoden bisher nicht weit verbreitet. Die bionische Topologieoptimierung von Behälter‐Stutzen‐Verbindungen soll eine höhere Festigkeit der Geometrien bei gleichzeitig geringerem Gewicht ermöglichen. Die Ergebnisse der Optimierung ergeben mithilfe von FEM Simulationen eine Spannungsreduktion von ca. 5 %, während das Gewicht um 59,9 % verringert werden konnte. Prototypen der optimierten Geometrien werden anschließend in 3D‐Druckverfahren produziert.
Alle Anforderungen erfüllt
Authors: Häffner Markus 
Published: June 2022

AbstractBei einem Austausch oder bei Neuanlagen in der Chemieindustrie ist es sinnvoll, schon vor Ende der übergangsfrist 2025 die Anforderungen der neuen TA‐Luft zu berücksichtigen. Ineos hat deshalb in seiner neuen Chemieanlage TA‐Luft‐konforme Armaturen gemäß der Novelle von 2021 von AS‐Schneider installiert.
Grundlage für eine effiziente Digitalisierung
Authors: Glas Thilo , Spiegel Christoph , Diewald Christian 
Published: June 2022

AbstractNOA und OPC UA ebnen den Weg zu Industrie 4.0 in der Prozessindustrie. Smarte IoT‐Tools warten lediglich auf die nötigen Daten. Längst sind in Brownfield‐Anlagen Tausende von intelligenten Feldgeräten installiert, die diese liefern könnten. Wie Diagnoseinformationen und Prozessmesswerte ohne großen Aufwand ihren Weg auf IoT‐Plattformen finden, zeigt eine skalierbare, sichere Best‐of‐Breed‐Lösung von drei erfahrenen Anbietern – die OT‐IT‐Bridge.
Mit Kraftmesstechnik Logistikkosten und CO2 sparen
Authors: Heidl Markus 
Published: June 2022

AbstractDas Reduzieren von Kraftfahrzeugabgasen durch effizientere Logistikprozesse kann einen wesentlichen Beitrag leisten, um klimafreundlicher und CO2‐ärmer zu produzieren. Kraftmesstechnik mit Funksensoren und IIoT‐Infrastruktur schafft die dazu notwendige Voraussetzung – sogar auf dem Weg der Nachrüstung.
Local Anesthetics via Multicomponent Reactions
Authors: Thomaidi Maria , Vagiaki Lida‐Evmorfia , Tripolitsiotis Nikolaos P. , Angeli Giasemi K. , Zarganes‐Tzitzikas Tryfon , Sidiropoulou Kyriaki , Neochoritis Constantinos G. 
Published: June 2022

AbstractLocal anesthetics occupy a prime position in clinical medicine as they temporarily relieve the pain by blocking voltage‐gated sodium channels. However, limited structural diversity, problems with the efficiency of syntheses and increasing toxicity, mean that alternative scaffolds with improved chemical syntheses are urgently needed. Here, we demonstrate a multicomponent reaction (MCR)‐based approach both towards the synthesis of commercial local anesthetics and towards novel derivatives as potential anesthesia candidates via scaffold hopping. The reactions are efficient and scalable, and several single‐crystal structures have been obtained. In addition, our methodology has been applied to the synthesis of the antianginal drug ranolazine, via an Ugi three‐component reaction. Representative derivatives from our libraries were evaluated as neuronal activity inhibitors using local field potential recordings (LFPs) in mouse hippocampal brain slices and showed very promising results. This study highlights new opportunities in drug discovery targeting local anesthetics.
Circulating tumor and invasive cell expression profiling predicts effective therapy in pancreatic cancer
Authors: Yu Kenneth H. , Park Jennifer , Mittal Avni , Abou‐Alfa Ghassan K. , El Dika Imane , Epstein Andrew S. , Ilson David H. , Kelsen David P. , Ku Geoffrey Y. , Li Jia , Park Wungki , Varghese Anna M. , Chou Joanne F‐L , Capanu Marinela , Cooper Brandon , Bartlett Andrew , McCarthy Devan , Sangar Vineet , McCarthy Brian , O'Reilly Eileen M. 
Published: June 2022

BackgroundPancreatic adenocarcinoma (PDAC) remains a refractory disease; however, modern cytotoxic chemotherapeutics can induce tumor regression and extend life. A blood‐based, pharmacogenomic, chemosensitivity assay using gene expression profiling of circulating tumor and invasive cells (CTICs) to predict treatment response was previously developed. The combination regimen of 5‐fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) and gemcitabine/nab‐paclitaxel (G/nab‐P) are established frontline approaches for treating advanced PDAC; however, there are no validated biomarkers for treatment selection. A similar unmet need exists for choosing second‐line therapy.MethodsThe chemosensitivity assay was evaluated in metastatic PDAC patients presenting for frontline treatment. A prospective study enrolled patients (n = 70) before receiving either FOLFIRINOX or G/nab‐P at a 1:1 ratio. Six milliliters of peripheral blood was collected at baseline and at time of disease progression. CTICs were isolated, gene‐expression profiling was performed, and the assay was used to predict effective and ineffective chemotherapeutic agents. Treating physicians were blinded to the assay prediction results.ResultsPatients receiving an effective regimen as predicted by the chemosensitivity assay experienced significantly longer median progression‐free survival (mPFS; 7.8 months vs. 4.2 months; hazard ratio [HR], 0.35; p = .0002) and median overall survival (mOS; 21.0 months vs. 9.7 months; HR, 0.40; p = .005), compared with an ineffective regimen. Assay prediction for effective second‐line therapy was explored. The entire study cohort experienced favorable outcomes compared with historical controls, 7.1‐month mPFS and 12.3‐month mOS.ConclusionsChemosensitivity assay profiling is a promising tool for guiding therapy in advanced PDAC. Further prospective validation is under way (clinicaltrials.gov NCT03033927).