bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of Neonates Born to COVID-19 Positive Mothers at a Tertiary Centre: A Retrospective Cohort Study
Authors: Hariharan S. , Manikumar S. , Muthukumaran N. , Ramya S. 
Published: June 2022

Introduction: In the context of the COVID-19 pandemic, studies on perinatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection play an essential role in the understanding of the disease which in turn is necessary for optimal management of affected neonates. Aim and Objective: To determine the clinical outcomes in neonates born to mothers with SARS-CoV-2 infection and to identify possible risk factors in perinatal transmission. Materials and Methods: This was a retrospective cohort study performed at level-3 teaching Neonatal Intensive Care Unit (NICU) in South India. Medical records of all mothers who delivered in the COVID-19 facility and neonates born to COVID-19 confirmed mothers from April 15, 2020, to September 15, 2021, were collected and analyzed. Results: Of 15,720 deliveries, 556 mothers who tested positive for COVID-19 delivered 563 babies (7 twins), of which 6.3% were positive for SARS-CoV-2. Out of 563 babies, 14.5% were preterm and 95% were asymptomatic. Among COVID-19 positive mothers, cesarean was the most common mode of delivery (73.5% and 88% in COVID-19 positive and negative neonates respectively; P value = .01) and most of the babies were roomed-in (85.2% in COVID-19 positive and 94.6% in COVID-19 negative neonates; P value = .02). COVID-19 positive neonates had significantly high probability of pneumonia ( P value = .003), sepsis ( P value = .03), septic shock ( P value = .01), and abnormal CXR ( P value = .01). There was no significant difference in the mortality rate. Conclusion: COVID-19 positive status of the mother is not associated with increased risk of preterm birth, neonatal admission, morbidity, or mortality. The risk of transmission was not found to be associated with direct breastfeeding or rooming-in.
The Efficacy and Safety of Anticoagulants in the Treatment of Cirrhotic Portal Vein Thrombosis: A Systematic Review and Meta-Analysis
Authors: Zhang Zhiqi , Zhao Ying , Han Baofeng , Zhu Zhijun , Sun Liying , Cui Xiangli 
Published: June 2022

Objective To evaluate the efficacy and safety of anticoagulant therapy in patients with cirrhotic PVT, and compare differences in efficacy and safety among different anticoagulants. Methods We comprehensively searched Pubmed, Cochrane Library, EMBASE, and ClinicalTrials.gov from inception to April 2022 for studies using anticoagulants for cirrhotic PVT. Meta-analysis was performed to calculate odds ratios (ORs) with 95% confidence intervals (CIs). Results 3 RCTs and 14 cohort studies involving 1270 patients were included. Anticoagulant therapy can increase the recanalization rate compared with non-anticoagulation therapy (OR 4.44, 95% CI 3.11-6.32, I2 = 2.5%) and can decrease the extension rate of cirrhotic PVT (OR 0.33, 95% CI 0.18-0.62, I2 = 41.0%), without increasing the incidence of total bleeding (OR 1.21, 95% CI 0.75-1.97, I2 = 9.8%), major bleeding (OR 0.98, 95% CI 0.49-1.95, I2 = 19.7%), and variceal bleeding (OR 0.35, 95% CI 0.12-1.01, I2 = 39.9%). Subgroup analysis showed that VKA, LMWH, and DOACs could increase the recanalization rate of PVT and were not associated with the risk of bleeding. Studies that compared direct oral anticoagulants (DOACs) with warfarin directly showed that the recanalization rate of PVT in the DOACs group might be higher than that in the warfarin group (OR 30.99, 95% CI 7.39-129.87, I2 = 0.0%), and there was no difference in the rate of total bleeding (OR 0.30, 95% CI 0.01-8.65, I2 = 79.6%). Conclusions Anticoagulants are safe and effective in patients with cirrhotic PVT. The rate of PVT recanalization associated with DOACs may be higher than warfarin.
Performance gaps between English speakers and Chinese-English speakers on classic semantic, action, and emotional verbal fluency
Authors: Lam Boji P. W. , Marquardt Thomas P. 
Published: June 2022

Aims and objectives: Semantic verbal fluency taps into vocabulary knowledge but often elicits poorer performance in bilingual speakers tested in a second language (L2). Few studies have examined verbal fluency tasks that target abstract words and examined test–retest reliability. The present study examined the performance gap between English speakers and Chinese-English speakers on classic semantic, action, and emotional verbal fluency. Methodology: English data were collected for six verbal fluency tasks from 41 English speakers and 18 Chinese-English speakers who spoke English as L2. Verbal fluency performance was reassessed one week later to examine test–retest reliability. Data and analysis: Verbal productivity, valence and arousal, test–retest reliability, and cross-session consistency in producing similar responses in repeated testing were analyzed. Morphological complexity of verbal responses also was compared because Chinese is morphologically simpler than English and emotional verbal fluency may trigger morphologically complex words. Findings/conclusions: Productivity gaps between groups were reliable for all tasks despite practice effects but were smaller for action and emotional verbal fluency. Words produced by Chinese-English speakers were more positive generally and less arousing for specific categories (e.g., “happy”). Both speaker groups were equally likely to produce variable responses with repeated testing, especially for emotional verbal fluency. Words produced by Chinese-English speakers were morphologically simpler than those produced by English speakers for emotional verbal fluency. Originality: Past work on semantic verbal fluency has focused on the retrieval of neutral and concrete words. This is the first study to assess the reliability in performance gaps between speakers tested in L1 and speakers tested in L2 on verbal fluency that targets the retrieval of abstract and emotional-laden words. Significance: Verbal fluency is one of the most frequently employed tasks in neuropsychological assessments. The findings demonstrate the effects of language proficiency on performance across verbal fluency variants, group differences in valence and arousal, the effects of repeated testing, and the effects of linguistic features on responses produced.
Study design of ‘Move More’: Development and feasibility of a social-prescribing intervention to increase physical activity among inactive Danes
Authors: Rasmussen Lene Gissel , Nielsen Rasmus Oestergaard , Kallestrup Per , Hawkins Jemma , Ryom Knud 
Published: June 2022

Aim: This paper describes the design of the ‘Move More’ study, which aims to develop and assess the feasibility of a social-prescribing intervention to increase physical activity among physically inactive Danes. Background: Physical inactivity constitutes a public-health challenge in Denmark. Social prescribing may be a promising tool to tackle physical inactivity by linking physical activity support from general practitioners with community-based activities in sports clubs, as this may help physically inactive citizens become more physically active. Given the range of stakeholders and behaviours required for social prescribing of physical activity, an intervention that harnesses this approach may constitute a complex intervention. The methods and decisions made in the stages of developing complex interventions are seldom reported. The present study enabled us to describe how co-creation can be used in a pragmatic development process for a complex intervention that considers the needs of stakeholders and the conditions of the delivery context. Methods: The study is based on the core elements of the development and feasibility phases of the Medical Research Council Framework for Developing and Evaluating Complex Interventions. Additionally, it is informed by a framework for the co-creation and prototyping of public-health interventions, drawing from a scoping review, stakeholder consultations and co-creation workshops. Ultimately, a feasibility study will be conducted to refine the programme theory by introducing the proposed intervention in case studies. Perspectives: The study will result in a prototype intervention manual and recommendations for implementation of an adapted social-prescribing intervention targeting physical inactivity in Denmark.
Design and characterization of a cotton fabric antenna for on-body thermotherapy
Authors: Mukai Yusuke , Suh Minyoung 
Published: June 2022

As a non-invasive therapeutic modality, microwave hyperthermia has gained increasing prominence in recent breast cancer research. In microwave hyperthermia, the temperature of a cancerous lesion is raised to 39–45°C by microwave irradiation to shrink tumors. Currently available applicators in clinics are aperture antennas (or waveguides) that are bulky and stationary; as such, patients are required to stay in an uncomfortable position for an extended period of time. On this account, this paper introduces the design and characterization of a novel cotton fabric antenna for a truly wearable and patient-friendly breast hyperthermia therapy. The developed antenna, consisting of cotton and copper-plated polyester fabrics, offers flexibility, tenacity, moisture-absorbing properties and breathability desirable for potential integration into intimate apparel. On the other hand, the use of cotton fabric brings about a major concern: moisture is documented to alter the dielectric properties of cotton fabrics and hence could impact the antenna performance. Therefore, for the purpose of concept and design validation, this research investigated the impedance matching and heating performance at three levels (20%, 65% and 80%) of relative humidity (RH). From both simulations and measurements, the RH was found to shift the resonant frequency slightly, but did not critically affect the impedance matching and the heating performance – the measured temperature rises were 4.7–4.9°C and 2.3–2.5°C at the depths of 5 mm and 15 mm, respectively. These theoretical and experimental insights cast light on the feasibility and benefits of moisture-absorbing, cotton-based medical textiles for administration of highly patient-friendly breast hyperthermia.
Accuracy and Safety of Non-Image Guided Trigger Finger Injections: A Cadaveric Study
Authors: Binz Daniel D. , Mitchell Thomas W. , Mitchell Scott A. 
Published: June 2022

Background: Stenosing flexor tenosynovitis is commonly treated by injection of corticosteroids into the flexor tendon sheath. However, there is no consensus in the literature regarding the optimal technique, specifically when not utilizing ultrasound guidance. Here, we present a cadaver study in which 3 common techniques of flexor sheath injection were compared with regard to their accuracy and safety profiles. Methods: Fifteen fresh-frozen cadaver hands (60 digits) were evenly divided into 3 groups (20 digits per group). Digits in each group were injected with methylene blue dye using 1 of the 3 techniques (palmar-to-bone, palmar supra-tendinous, and mid-axial). The fingers were then dissected and were inspected for location of dye, as well as injury to tendon or digital nerves. Results: The mid-axial technique demonstrated the greatest accuracy with the highest rate of all intra-sheath injection, 15 of 20 digits (75%), while the palmar-to-bone technique produced the most combined intra- and extra-sheath injections, 13 of 20 digits, (65%) and the palmar supra-tendinous technique resulted in the most all extra-sheath injections, 9 of 20 digits (45%). The difference in rates of all intra-sheath injection was significant ( P = .01). The mid-axial technique also produced the fewest intra-tendinous injections 0 of 20, although this result did not reach statistical significance ( P = .15). Conclusions: Compared to other common non-image guided flexor tendon sheath injection techniques, the mid-axial injection technique was found to be the most accurate in producing all intra-sheath injection and least likely to result in intra-tendinous injection.
Incidence of (Osteo)Chondral Lesions of the Ankle in Isolated Syndesmotic Injuries: A Systematic Review and Meta-Analysis
Authors: Dahmen Jari , Jaddi Sohaib , Hagemeijer Noortje C. , Lubberts Bart , Sierevelt Inger N. , Stufkens Sjoerd A.S. , d’Hooghe Pieter , Kennedy John G. , Calder James D. F. , DiGiovanni Christopher W. , Kerkhoffs Gino M. M. J. 
Published: June 2022

Objective To determine and compare the incidence rate of (osteo)chondral lesions of the ankle in patients with acute and chronic isolated syndesmotic injuries. Design A literature search was conducted in the PubMed (MEDLINE) and EMBASE (Ovid) databases from 2000 to September 2021. Two authors independently screened the search results, and risk of bias was assessed using the MINORS (Methodological Index for Non-Randomized Studies) criteria. Studies on acute and chronic isolated syndesmotic injuries with pre-operative or intra-operative imaging were included. The primary outcome was the incidence rate with corresponding 95% confidence intervals (CIs) of (osteo)chondral lesions of the ankle in combined and separate groups of acute and chronic syndesmotic injuries. Secondary outcomes were anatomic distribution and mean size of the (osteo)chondral lesions. Results Nine articles (402 syndesmotic injuries) were included in the final analysis. Overall (osteo)chondral lesion incidence was 20.7% (95% CI: 13.7%-29.9%). This rate was 22.0% (95% CI: 17.1-27.7) and 24.1% (95% CI: 15.6-35.2) for acute and chronic syndesmotic injuries, respectively. In the combined acute and chronic syndesmotic injury group, 95.4% of the lesions were located on the talar dome and 4.5% of the lesions were located on the distal tibia. (Osteo)chondral lesion size was not reported in any of the studies. Conclusions This meta-analysis shows that (osteo)chondral lesions of the ankle are present in 21% of the patients with isolated syndesmotic injuries. No difference in incidence rate was found between the different syndesmotic injury types and it can be concluded that the majority of lesions are located on the talar dome. PROSPERO Registration Number: CRD42020176641
Is Nonoperative Treatment Appropriate for All Patients With Type 1 Tibial Spine Fractures? A Multicenter Study of the Tibial Spine Research Interest Group
Authors: Shimberg Jilan L. , Leska Tomasina M. , Cruz Aristides I. , Ellis Henry B. , Patel Neeraj M. , Yen Yi-Meng ,   Tibial Spine Research Interest Group, Schmale Gregory A. , Mistovich R. Justin , Fabricant Peter D. , Ganley Theodore J. , Green Daniel W. , Johnson Benjamin , Kushare Indranil , Lee R. Jay , McKay Scott D. , Milbrandt Todd A. , Rhodes Jason , Sachleben Brant , Traver Jessica L. 
Published: June 2022

Background: Type 1 tibial spine fractures are nondisplaced or ≤2 mm–displaced fractures of the tibial eminence and anterior cruciate ligament (ACL) insertion that are traditionally managed nonoperatively with immobilization. Hypothesis: Type 1 fractures do not carry a significant risk of associated injuries and therefore do not require advanced imaging or additional interventions aside from immobilization. Study Design: Case series; Level of evidence, 4. Methods: We reviewed 52 patients who were classified by their treating institution with type 1 tibial spine fractures. Patients aged ≤18 years with pretreatment plain radiographs and ≤ 1 year of follow-up were included. Pretreatment imaging was reviewed by 4 authors to assess classification agreement among the treating institutions. Patients were categorized into 2 groups to ensure that outcomes represented classic type 1 fracture patterns. Any patient with universal agreement among the 4 authors that the fracture did not appear consistent with a type 1 classification were assigned to the type 1+ (T1+) group; all other patients were assigned to the true type 1 (TT1) group. We evaluated the rates of pretreatment imaging, concomitant injuries, and need for operative interventions as well as treatment outcomes overall and for each group independently. Results: A total of 48 patients met inclusion criteria; 40 were in the TT1 group, while 8 were in the T1+ group, indicating less than universal agreement in the classification of these fractures. Overall, 12 (25%) underwent surgical treatment, and 12 (25%) had concomitant injuries. Also, 8 patients required additional surgical management including ACL reconstruction (n = 4), lateral meniscal repair (n = 2), lateral meniscectomy (n = 1), freeing an incarcerated medial meniscus (n = 1), and medial meniscectomy (n = 1). Conclusion: The classification of type 1 fractures can be challenging. Contrary to prior thought, a substantial number of patients with these fractures (>20%) were found to have concomitant injuries. Overall, surgical management was performed in 25% of patients in our cohort.
Optical Coherence Tomography Angiography in Pediatric Retinal Disorders
Authors: Ponugoti Arathi , Baumal Caroline R. , Vajzovic Lejla 
Published: June 2022

Purpose: The rapid and noninvasive nature of optical coherence tomography angiography (OCTA) makes it a potentially valuable tool for imaging the retina in children. With the optimization of tabletop systems and the development of experimental handheld OCTA devices, there is expanded potential for OCTA in the clinic and the operating room. This article reviews the utility of OCTA in some of the most common pediatric retinal disorders. Methods: A thorough computerized PubMed search was performed to review relevant published journal articles to contextualize and identify the role of OCTA in common retinal disorders with vascular involvement affecting children. Pertinent results and findings from original investigations and case reports were summarized. Results: The ability to quickly collect both qualitative and quantitative information about retinal microvasculature, in both the clinic and operating room settings, with OCTA, has led to the uncovering of microvascular features and morphologic changes in many pediatric retinal disorders such as Coats Disease, familial exudative vitreoretinopathy, incontinentia pigmenti, sickle cell retinopathy, Stargardt Disease, X-linked juvenile retinoschisis, retinopathy of prematurity, diabetic retinopathy in type 1 diabetes, pediatric retinal tumors, and choroidal neovascularization. Conclusions: OCTA is a relevant tool to aid early detection, guide intervention, monitor treatment response, and understand pathogenesis in a number of pediatric retinal disorders.
Microstructural and mechanical characterization of steel-DP780/Al-5052 joints formed using resistance element welding with concealed rivet cover
Authors: Cai Wanyue , Chen Qi , Wang Yijin , Dong Shijie , Luo Ping 
Published: June 2022

Resistance element welding (REW) with a concealed rivet cover (Q235) was used to join steel-DP780 and Al-5052. The macroscopic morphology and the microstructure were observed using optical microscopy and scanning electron microscopy. The mechanical properties of the joint were also tested. The results show that the intermetallic compound (IMC) formed at the Q235/Al interface is FeAl3, while the IMCs formed at the DP780/Al interface are Fe2Al5 and FeAl3. The welding current has a significant influence on the nugget size, peak load, average hardness of aluminum heat-affected zone, and the bearing area of the aluminum plate. There are three fracture models of the countersunk rivet REW joint under a tensile-shear force: the interface failure fracture model, the fusion pullout failure fracture model, and the heat-affected zone failure fracture model. At a welding current of 18 kA, the nugget pullout failure mode is observed, and the best mechanical properties of the joint are obtained. The shear resistance of the joint can reach up to 5712 N.
Effects of a history of headache and migraine treatment on baseline neurocognitive function in young athletes
Authors: McCarthy Lily , Hannah Theodore C. , Li Adam Y. , Schupper Alexander J. , Hrabarchuk Eugene , Kalagara Roshini , Ali Muhammad , Gometz Alex , Lovell Mark R. , Choudhri Tanvir F. 
Published: June 2022

Abstract
Objective/background
Despite the prevalence of concussions in young athletes, the impact of headaches on neurocognitive function at baseline is poorly understood. We analyze the effects of a history of headache treatment on baseline ImPACT composite scores in young athletes.

Methods
A total of 11,563 baseline ImPACT tests taken by 7,453 student-athletes ages 12-22 between 2009 and 2019 were reviewed. The first baseline test was included. There were 960 subjects who reported a history of treatment for headache and/or migraine (HA) and 5,715 controls (CT). The HA cohort included all subjects who self-reported a history of treatment for migraine or other type of headache on the standardized questionnaire. Chi-squared tests were used to compare demographic differences. Univariate and multivariate regression analyses were used to assess differences in baseline composite scores between cohorts while controlling for demographic differences and symptom burden.

Results
Unadjusted analyses demonstrated that HA was associated with increased symptoms (β=2.30, 95% CI: 2.18-2.41, p<.0001), decreased visual memory (β=-1.35, 95% CI: -2.62 to -0.43, p=.004), and increased visual motor speed (β=0.71, 95% CI: 0.23-1.19, p=.004) composite scores. Baseline scores for verbal memory, reaction time, and impulse control were not significantly different between cohorts. Adjusted analyses demonstrated similar results with HA patients having greater symptom burden (β=1.40, 95% CI: 1.10-1.70, p<.0001), lower visual memory (β=-1.25, 95% CI: -2.22 to -0.27, p=.01), and enhanced visual motor speed (β=0.60, 95% CI: 0.11-1.10, p=.02) scores.

Conclusion
HA affected symptom, visual motor speed, and visual memory ImPACT composite scores. Visual memory scores and symptom burden were significantly worse in the HA group while visual motor speed scores were better, which may have been due to higher stimulant use in the HA group. The effects of HA on visual motor speed and visual memory scores were independent of the effects of the increased symptom burden.