bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ornithinibacillus
Authors: Wenning Mareike , Scherer Siegfried 
Published: December 2022

AbstractOrnithinibacillus(Or.ni.thi.ni.ba.cil'lus. N.L. neut. n.ornithinum, ornithine; L. masc. n.bacillus, a small staff, a wand; N.L. masc. n.Ornithinibacillus, a rod with ornithine).Bacillota / Bacilli / Bacillales / Bacillaceae / OrnithinibacillusThe genusOrnithinibacilluswas proposed in 2006 with the description ofOrnithinibacillus(O.)bavariensisandOrnithinibacillus californiensisthat originated from pasteurized milk and coastal surface sediment. Currently, 10 species with validly published names have been described, and soil and saline environments seem to be the preferred habitats of this genus.Ornithinibacillusspecies are rod‐shaped Gram‐positive cells, 0.2–1 × 1–20 μm in size and mostly, but not in all cases, motile by peritrichous flagella. Terminal spores are produced in swollen sporangia. Colonies are often colored brownish orange or beige‐brownish but may also be creamy white or translucent. All species are strictly aerobic and halotolerant or slightly halophilic and display hemolytic activity. The quinone system contains MK‐7 as the dominating menaquinone. The fatty acid composition of most species is characterized by a dominance of iso‐C15:0or anteiso‐C15:0; some species, however, contain larger amounts of iso‐C16:0or anteiso‐C17:0.Ornithinibacillusis genetically closely related to its neighbor genusOceanobacillus, and a clear distinction is possible only by the analysis of the peptidoglycan type. The defining characteristic forOrnithinibacillusis the A4β (l‐Orn–d‐Asp) or A4α (l‐Lys–d‐Asp) peptidoglycan type, whileOceanobacillusdisplays an A1γ type withmeso‐DAP as the diagnostic amino acid.DNA G + C content (mol%): 35.9–40.4.Type species:Ornithinibacillus bavariensisMayr et al. 2006VP.
Tepidibacillus
Authors: Slobodkina Galina 
Published: December 2022

Abstract

Te.pi.di.ba.cil'lus. L. masc. adj.
tepidus
, warm; L. masc. n.
bacillus
, small rod; N.L. masc. n.
Tepidibacillus
, a small rod from a warm habitat.

Firmicutes / Bacilli / Bacillales / Bacillaceae / Tepidibacillus

The genus
Tepidibacillus
accommodates Gram‐stain‐positive, spore‐forming, and rod‐shaped motile bacteria. Species of the genus are facultatively anaerobic and microaerobic, neutrophilic moderate thermophiles. They grow chemoorganoheterotrophically with a number of carbohydrates, proteinaceous substrates, organic acids, and alcohols either by respiration or fermentation. The major cellular fatty acids are C
15:0
, anteiso‐C
15:0
, iso‐C
15:0
, C
16:0
, iso‐C
16:0
, and C
18:0
. The genus
Tepidibacillus
is a member of the family
Bacillaceae
and class “
Bacilli
.” The main habitats of the genus are subsurface ecosystems. The type species,
Tepidibacillus fermentans
, was isolated from the production water of an underground gas storage reservoir (North Caucasus Region, Russia).

DNA G + C content (mol%):
35.4–36.6 (genome data).

Type species
:
Tepidibacillus fermentans
Slobodkina et al. 2013, VL155.
Herodes Atticus
Authors: Bowie Ewen L. 
Published: December 2022

AbstractBorn ca. 101ce, Herodes Atticus combined Athenian and Roman careers, becomingconsul ordinariusin 143. The premier sophist of Philostratus’Lives, Herodes taught many sophists later prominent. His huge wealth was augmented by that of his wife Regilla: together they built a nymphaeum at Olympia; on her death he commemorated her by the Athens Odeion; he also built at Corinth, Canusium, and Alexandria. Ca. 174 quarrels with Athenians caused his exile until Marcus Aurelius brokered a reconciliation. On his death (177) he was buried in the Panathenaic stadium he had clad in marble for the Panathenaea of 140.
Development of Mitochondria Targeting AIE‐Active Cyclometalated Iridium Complexes as Potent Antimalarial Agents
Authors: Kumari Geeta , Gupta Ajay , Sah Raj Kumar , Gautam Aryan , Saini Monika , Gupta Aashima , Kushawaha Akhilesh K. , Singh Shailja , Sasmal Pijus K. 
Published: December 2022

AbstractThe emergence of resistance to conventional antimalarial treatments remains a major cause for concern. New drugs that target the distinct development stages of Plasmodium parasites are required to address this risk. Herein, water‐soluble aggregation‐induced emission active cyclometalated iridium(III) polypyridyl complexes (Ir1–Ir12) are developed for the elimination of malaria parasites. Remarkably, these complexes show potent antimalarial activity in low nanomolar range against 3D7 (chloroquine and artemisinin sensitive strain), RKL9 (chloroquine resistant strain), and R539T (artemisinin resistant strains) strains of Plasmodium falciparum with faster killing rate of malaria parasites. Concomitantly, these complexes exhibit efficient in vivo antimalarial activity against both the asexual and gametocyte stages of Plasmodium berghei malaria parasite, suggesting promising transmission‐blocking potential. The complexes tend to localize into mitochondria of P. falciparum determined by image and cell‐based assay. The mechanistic studies reveal that these complexes exert their antimalarial activity by increasing reactive oxygen species levels and disrupting its mitochondrial membrane potential. Furthermore, the mitochondrial‐dependent antimalarial activity of these complexes is confirmed in yeast model. Thus, this study for the first time highlights the potential role of targeting P. falciparum mitochondria by iridium complexes in discovering and developing the next‐generation antimalarial agents for treating multidrug resistant malaria parasites.
Photomagnetically Powered Spiky Nanomachines with Thermal Control of Viscosity for Enhanced Cancer Mechanotherapy
Authors: Xu Chang , Liu Yali , Li Jiayan , Ning Peng , Shi Zhong , Zhang Wei , Li Zhenguang , Zhou Ruimei , Tong Yifan , Li Yingze , Lv Cheng , Shen Yajing , Cheng Qian , He Bin , Cheng Yu 
Published: December 2022

AbstractNanomachines with active propulsion have emerged as an intelligent platform for targeted cancer therapy. Achieving an efficient locomotion performance using an external energy conversion is a key requirement in the design of nanomachines. In this study, inspired by diverse spiky structures in nature, a photomagnetically powered nanomachine (PMN) with a spiky surface and thermally dependent viscosity tunability is proposed to facilitate mechanical motion in lysosomes for cancer mechanotherapy. The hybrid nanomachine is integrated with magnetic nanoparticles as the core and covered with gold nanotips. Physical simulations and experimental results prove that the spiky structure endows nanomachines with an obvious photomagnetic coupling effect in the NIR‐II region through the alignment and orienting movement of plasmons on the gold tips. Using a coupling‐enhanced magnetic field, PMNs are efficiently assembled into chain‐like structures to further elevate energy conversion efficiency. Notably, PMNs with the thermal control of viscosity are efficiently propelled under simultaneously applied dual external energy sources in cell lysosomes. Enhanced mechanical destruction of cancer cells via PMNs is confirmed both in vitro and in vivo under photomagnetic treatment. This study provides a new direction for designing integrated nanomachines with active adaptability to physiological environments for cancer treatment.
Nano‐Confined Growth of Perovskite Quantum Dots in Transparent Nanoporous Glass for Luminescent Chemical Sensing
Authors: Hu Zhiping , Jiang Yiguang , Zhou Fengxian , Chen Chunlin , He Jin , Zhan Zijun , Liu Zhengzheng , Du Juan , Zhang Long , Leng Yuxin 
Published: December 2022

AbstractPrior nano‐confined matrices for perovskite quantum dots (QDs) dealt only with powders or thin films, which usually suffer from poor handling properties and high transparency limitations for integrating into optical devices. Here, the nano‐confined growth of perovskite QDs in an optically transparent, robust, and monolithic matrix by using nanoporous glass (NG) as a nano‐reactor is demonstrated. Owing to quantum confinement effects in the inherent nanoporous network, rapid nanoconfined low‐temperature solution‐processed perovskite QDs could synthesize spontaneously. The binding energy of CsPbBr3 QDs in NG has been enhanced to ≈177.2 meV due to the confinement effect. The nano‐channels enable the tunable mono/multi‐color emission in full visible range via pore size tailoring or post‐halide exchange. Considering the fast diffusion of nanoporous channels and enhanced stability in this processable monolithic composite, a rapid‐response and reusable red‐green switching light‐emitting diode (LED) sensor for halomethanes is demonstrated. The rational design of perovskite NG via this efficient nano‐confined route results in a new optoelectronic device‐relevant material platform.
A 3D‐Bioprinted Functional Module Based on Decellularized Extracellular Matrix Bioink for Periodontal Regeneration
Authors: Yang Xueting , Ma Yue , Wang Xiuting , Yuan Shengmeng , Huo Fangjun , Yi Genzheng , Zhang Jingyi , Yang Bo , Tian Weidong 
Published: December 2022

AbstractPoor fiber orientation and mismatched bone–ligament interface fusion have plagued the regeneration of periodontal defects by cell‐based scaffolds. A 3D bioprinted biomimetic periodontal module is designed with high architectural integrity using a methacrylate gelatin/decellularized extracellular matrix (GelMA/dECM) cell‐laden bioink. The module presents favorable mechanical properties and orientation guidance by high‐precision topographical cues and provides a biochemical environment conducive to regulating encapsulated cell behavior. The dECM features robust immunomodulatory activity, reducing the release of proinflammatory factors by M1 macrophages and decreasing local inflammation in Sprague Dawley rats. In a clinically relevant critical‐size periodontal defect model, the bioprinted module significantly enhances the regeneration of hybrid periodontal tissues in beagles, especially the anchoring structures of the bone–ligament interface, well‐aligned periodontal fibers, and highly mineralized alveolar bone. This demonstrates the effectiveness and feasibility of 3D bioprinting combined with a dental follicle‐specific dECM bioink for periodontium regeneration, providing new avenues for future clinical practice.
Grazing intensity and nitrogen fertilization effects on biomass and morphology of black oat roots in an integrated crop–livestock system
Authors: Ribeiro Ricardo Henrique , Ibarr Mariana Alves , Bratti Felipe , Pinheiro Denis , Auler André Carlos , Chiavegato Marília Barbosa , Piva Jonatas Thiago , Dieckow Jeferson 
Published: December 2022

AbstractGrazing stimulates root and forage mass of perennial pastures, but few studies have addressed the effects of grazing on annual pastures which are often grown in short periods within integrated crop–livestock systems (ICLS). In these pastures, N fertilization is a common practice to increase forage mass, but its effects on root morphology are unclear. In a field experiment, we evaluated how grazing intensities (ungrazed, moderate, and heavy grazing) and N fertilization rates (0, 75, and 150 kg N ha−1) affected morphological attributes of oat (Avena strigosa Schreb.) roots and forage accumulation in ICLS in Brazilian subtropics. Forage mass was evaluated in each grazing cycle and roots were sampled to a 30‐cm depth at the end of the grazing season in 2 years. Heavy and moderate grazing reduced (p < 0.05) forage accumulation by 15%–37% compared to ungrazed (4867 kg DM ha−1) in the first year, characterized by extended periods of water deficit, but in the second year forage accumulation from grazed and ungrazed was similar (p > 0.05), averaging 4273 kg ha−1. N fertilization increased forage accumulation in both the years, without differences between 75 and 150 kg N ha−1 in grazed treatments. Grazing and N rates mainly reduced root diameter and increased root N concentration. Increasing N fertilization rates increased root length but it was more expressive in the first year. Nitrogen fertilization with 75 or 150 kg N ha−1 on moderately grazed oat is an alternative to increase forage accumulation as it stimulates fine root development and increase N uptake, mainly when adverse climatic conditions can affect pasture growth.
Towards tunable polymer foam fabrication: A case study to advance green materials development in limited data scenarios
Authors: Pollard Zoe A. , Roshandelpoor Athar , Vakili Pirooz , Ryan Emily , Goldfarb Jillian L. 
Published: December 2022

AbstractEarly phases of green material development can be accelerated by identifying driving factors that control material properties to understand potential tradeoffs. Full investigation of fabrication variables is often prohibitively expensive. We propose a pared‐down design of experiments (DOE) approach to identify driving variables in limited data scenarios using tunable polydimethylsiloxane (PDMS) foams made via sacrificial templating as an example system. This new approach systematically determines the dependencies of porosity, transparency, and fluid flow by varying the template particle size and packing while using a more sustainable solvent. Factor screening identified template particle size and packing density as the driving factors for foam performance by controlling pore size and interconnectivity. The framework developed provides a robust, foundational understanding of how to green and tune a novel material's properties using an efficient and effective exploration of the design space. Recommendations for applying this method to a broad suite of experiments are provided.
Liquid‐liquid heterogeneous mixing efficiency in a rotating packed bed reactor
Authors: Zhang Yi‐Dong , Zhang Liang‐Liang , Wang Ze‐Xin , Sun Bao‐Chang , Chu Guang‐Wen , Chen Jian‐Feng 
Published: December 2022

AbstractMixing of two immiscible liquids consists of two sections that are liquid‐liquid dispersion and mass transfer intraphase or interphase. It plays a crucial role in the liquid‐liquid heterogeneous reactions. Here, the liquid‐liquid heterogeneous mixing efficiency in RPB reactor is experimentally assessed by a consecutive‐competitive chemical probe system. The diameters of dispersed phase droplets in RPB were measured and a correlation to predict the mean diameters were obtained. Based on the dispersed phase size and mass transfer characteristic, a model for predicting the segregation index of liquid‐liquid heterogeneous mixing in RPB was established with a deviation <20%. Based on this model, the characteristic time of liquid‐liquid heterogeneous mixing in RPB is determined to be in the range of 0.01–1 s. RPB exhibits a great process intensification potential for heterogeneous mixing process.
Management of nutritional and gastrointestinal issues in RASopathies: A narrative review
Authors: Onesimo Roberta , Giorgio Valentina , Viscogliosi Germana , Sforza Elisabetta , Kuczynska Eliza , Margiotta Gaia , Iademarco Mariella , Proli Francesco , Rigante Donato , Zampino Giuseppe , Leoni Chiara 
Published: December 2022

AbstractNoonan, Costello, and cardio‐facio‐cutaneous syndrome are neurodevelopmental disorders belonging to the RASopathies, a group of syndromes caused by alterations in the RAS/MAPK pathway. They are characterized by similar clinical features, among which feeding difficulties, growth delay, and gastro‐intestinal disorders are frequent, causing pain and discomfort in patients. Hereby, we describe the main nutritional and gastrointestinal issues reported in individuals with RASopathies, specifically in Noonan syndrome, Noonan syndrome‐related disorders, Costello, and cardio‐facio‐cutaneous syndromes. Fifty percent of children with Noonan syndrome may experience feeding difficulties that usually have a spontaneous resolution by the second year of life, especially associated to genes different than PTPN11 and SOS1. More severe manifestations often require artificial enteral nutrition in infancy are observed in Costello syndrome, mostly associated to c.34G>A substitution in the HRAS gene. In cardio‐facio‐cutaneous syndrome feeding issues are usually present (90–100% of cases), especially in individuals carrying variants in BRAF, MAP2K1, and MAP2K2 genes, and artificial enteral intervention, even after scholar age, may be required. Moreover, disorders associated with gastrointestinal dysmotility as gastro‐esophageal reflux and constipation are commonly reported in all the above‐mentioned syndromes. Given the impact on growth and on the quality of life of these patients, early evaluation and prompt personalized management plans are fundamental.
Charge‐Assisted Halogen Bonding in an Ionic Cavity of a Coordination Cage Based on a Copper(I) Iodide Cluster
Authors: Peuronen Anssi , Taponen Anni I. , Kalenius Elina , Lehtonen Ari , Lahtinen Manu 
Published: December 2022

AbstractThe design of molecular containers capable of selectively binding specific guest molecules presents an interesting synthetic challenge in supramolecular chemistry. Here, we report the synthesis and structure of a coordination cage assembled from Cu3I4− clusters and tripodal cationic N‐donor ligands. Owing to the localized permanent charges in the ligand core the cage binds iodide anions in specific regions within the cage through ionic interactions. This allows the selective binding of bromomethanes as secondary guest species within the cage promoted by halogen bonding, which was confirmed by single‐crystal X‐ray diffraction.
Ligand‐Controlled Nickel‐Catalyzed Regiodivergent Cross‐Electrophile Alkyl‐Alkyl Couplings of Alkyl Halides
Authors: Zhao Wen‐Tao , Meng Huan , Lin Jia‐Ni , Shu Wei 
Published: December 2022

AbstractFunctionalizing specific positions on a saturated alkyl molecule is a key challenge in synthetic chemistry. Herein, a ligand‐controlled regiodivergent alkylations of alkyl bromides at different positions by Ni‐catalyzed alkyl‐alkyl cross‐electrophile coupling with the second alkyl bromides has been developed. The reaction undergoes site‐selective isomerization on one alkyl bromides in a controlled manner, providing switchable access to diverse alkylated structures at different sites of alkyl bromides. The reaction occurs at three similar positions with excellent chemo‐ and regioselectivity, representing a remarkable ligand tuned reactivity between alkyl‐alkyl cross‐coupling and nickel migration along the hydrocarbon side chain. This reaction offers a catalytic platform to diverse saturated architectures by alkyl‐alkyl bond‐formation from identical starting materials.
Conjugated and Non‐conjugated Polymers Containing Two‐Electron Redox Dihydrophenazines for Lithium‐Organic Batteries
Authors: Zhao Xiang , Qiu Xuan , Xue Haodong , Liu Si , Liang Dingli , Yan Chuan , Chen Weinan , Wang Yonggang , Zhou Gang 
Published: December 2022

AbstractOrganic p‐type cathode materials have recently attracted increasing attention due to their higher redox potentials and rate capabilities in comparison to n‐type cathodes. However, most of the p‐type cathodes based on one‐electron redox still suffer from limited stability and low specific capacity (<150 mAh g−1). Herein, two polymers, conjugated poly(diethyldihydrophenazine vinylene) (CPP) and non‐conjugated poly(diethyldihydrophenazine ethylidene) (NCPP) containing two‐electron redox dihydrophenazine, have been developed as p‐type cathode materials. It is experimentally and theoretically found that the conjugated linkage among the redox centers in polymer CPP is more favorable for the effective charge delocalization on the conjugated polymer backbone and the sufficient oxidation in the higher potential region (3.3–4.2 V vs. Li/Li+). Consequently, the CPP cathode displays a higher reversible specific capacity of 184 mAh g−1 with excellent cycling stability.
Elastic Moduli: a Tool for Understanding Chemical Bonding and Thermal Transport in Thermoelectric Materials
Authors: Isotta Eleonora , Peng Wanyue , Balodhi Ashiwini , Zevalkink Alexandra 
Published: December 2022

AbstractThe elastic behavior of a material can be a powerful tool to decipher thermal transport. In thermoelectrics, measuring the elastic moduli—directly tied to sound velocity—is critical to understand trends in lattice thermal conductivity, as well as study bond anharmonicity and phase transitions, given the sensitivity of elastic moduli to the chemical bonding. In this review, we introduce the basics of elasticity and explain the origin of high‐temperature lattice softening from a bonding perspective. We then review elasticity data throughout classes of thermoelectrics, and explore trends in sound velocity, anharmonicity, and thermal conductivity. We reveal how experimental sound velocities can improve the accuracy of common thermal conductivity models and present a critical discussion of Grüneisen parameter estimates from elastic moduli. Readers will be equipped with tools to leverage elasticity measurements or calculations to accurately interpret thermal transport trends.
A Fluorogenic Inhibitor of the Mitochondrial Calcium Uniporter
Authors: Huang Zhouyang , MacMillan Samantha N. , Wilson Justin J. 
Published: December 2022

AbstractInhibitors of the mitochondrial calcium uniporter (MCU) are valuable tools for studying the role of mitochondrial Ca2+in various pathophysiological conditions. In this study, a new fluorogenic MCU inhibitor,RuOCou, is presented. This compound is an analogue of the known MCU inhibitor Ru265 that contains fluorescent axial coumarin carboxylate ligands. Upon aquation ofRuOCouand release of the axial coumarin ligands, a simultaneous increase in its MCU‐inhibitory activity and fluorescence intensity is observed. The fluorescence response of this compound enabled its aquation to be monitored in both HeLa cell lysates and live HeLa cells. This fluorogenic prodrug represents a potential theranostic MCU inhibitor that can be leveraged for the treatment of human diseases related to MCU activity.
Controlled Growth and Chemical Engineering of FeSe‐Based Superconducting Films
Authors: Huang Yulong , Ren Shenqiang 
Published: December 2022

AbstractChemical engineering tailors functional materials to meet the demands of physical and chemical properties, accelerating materials discovery and design in a multidisciplinary field. However, stereotyped synthetic paradigms in physical and chemical approaches obstruct the effective integration of multiple advantages of respective materials exploration methods. Solid state reaction is often considered separately with wet chemistry synthesis route, such as film growth using physical vapor deposition and hydrothermal methods. Here, the controlled growth of FeSe thin films by physical deposition techniques followed by the chemical engineering to create heterogenous interface in FeSe films via a solution‐based environment is demonstrated. The two‐step route allows an expanded crystal structure and enhanced superconducting transition temperature from 3.6 to 38 K, providing a new strategy to design functional hybrid materials.