bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining resuscitation outcomes in combat casualties: Design of the Deployed Hemostatic Emergency Resuscitation of Traumatic Exsanguinating Shock (Deployed HEROES) study
Authors: Gurney Jennifer M. , Staudt Amanda M. , del Junco Deborah J. , Holcomb John , Martin Matthew , Spinella Phil , Trevino Jennifer D. , Corley Jason B. , Taylor Audra L. , Rohrer Andrew , Schreiber Martin , Cap Andrew 
Published: May 2022

BACKGROUND
During the course of the recent conflicts, the recommendations for resuscitation practices have evolved, but there has been no comprehensive comparative effectiveness study of these resuscitation strategies. The objective of this study was to describe the development and study design of the Deployed Hemostatic Emergency Resuscitation of Traumatic Exsanguinating Shock (Deployed HEROES) study—the first comprehensive analysis of military resuscitation practices in the deployed environment from October 2001 to October 2019.

METHODS
This retrospective cohort study uses the Department of Defense Trauma Registry, Armed Services Blood Program database, and Military Trauma Mortality Review, while abstractors will use Theater Medical Data Store and Web Interface Patient Records to collect transfusion timing data. This study includes patients, who received blood products or died before receiving blood, treated at US military medical treatment facilities. The primary endpoints are survival at 6 hours, 24 hours, and 30 days postinjury. Secondary outcomes include infection, renal dysfunction, pulmonary dysfunction, and thromboembolic event. Exposure will be defined by blood product transfusion. Study groups will be frequency matched. Cox proportional hazards will compare patients who received warm fresh whole blood, low titer type-O whole blood, or only component therapy, while using adjustment for type of blood product transfused as a time-dependent covariate. Multilevel mixed-effects logistic regression will determine the effect of incompatible plasma in low titer type-O whole blood.

RESULTS
An analysis plan for the Deployed HEROES study was developed with the aim of minimizing bias.

CONCLUSION
This study will inform the optimal resuscitation strategies, which will potentially have a substantial impact on combat mortality. If whole blood is found to be the optimal transfusion strategy, this finding will be crucial in future operating environments involving dispersed medical assets. These results will provide critical information necessary for combat casualty care guidelines.

LEVEL OF EVIDENCE
Prognostic and epidemiological; Level III.
Management of the open abdomen: A systematic review with meta-analysis and practice management guideline from the Eastern Association for the Surgery of Trauma
Authors: Mahoney Eric J. , Bugaev Nikolay , Appelbaum Rachel , Goldenberg-Sandau Anna , Baltazar Gerard A. , Posluszny Joseph , Dultz Linda , Kartiko Susan , Kasotakis George , Como John , Klein Eric 
Published: May 2022

BACKGROUND
Multiple techniques describe the management of the open abdomen (OA) and restoration of abdominal wall integrity after damage-control laparotomy (DCL). It is unclear which operative technique provides the best method of achieving primary myofascial closure at the index hospitalization.

METHODS
A writing group from the Eastern Association for the Surgery of Trauma performed a systematic review and meta-analysis of the current literature regarding OA management strategies in the adult population after DCL. The group sought to understand if fascial traction techniques or techniques to reduce visceral edema improved the outcomes in these patients. The Grading of Recommendations Assessment, Development and Evaluation methodology was utilized, meta-analyses were performed, and an evidence profile was generated.

RESULTS
Nineteen studies met inclusion criteria. Overall, the use of fascial traction techniques was associated with improved primary myofascial closure during the index admission (relative risk, 0.32) and fewer hernias (relative risk, 0.11.) The use of fascial traction techniques did not increase the risk of enterocutaneous fistula formation nor mortality. Techniques to reduce visceral edema may improve the rate of closure; however, these studies were very limited and suffered significant heterogeneity.

CONCLUSION
We conditionally recommend the use of a fascial traction system over routine care when treating a patient with an OA after DCL. This recommendation is based on the benefit of improved primary myofascial closure without worsening mortality or enterocutaneous fistula formation. We are unable to make any recommendations regarding techniques to reduce visceral edema.

LEVEL OF EVIDENCE
Systematic Review and Meta-Analysis; Level IV.
Blunt splenic injury in adults: Association between volumetric quantitative CT parameters and intervention
Authors: Dreizin David , Champ Kathryn , Dattwyler Matthew , Bodanapally Uttam , Smith Elana B. , Li Guang , Singh Rohan , Wang Ze , Liang Yuanyuan 
Published: May 2022

Computed tomography volumetry of blunt splenic injury-related features predicts splenectomy and angioembolization in adults and identifies clinically important target features for computer vision and automation research.

BACKGROUND
Several ordinal grading systems are used in deciding whether to perform angioembolization (AE) or splenectomy following blunt splenic injury (BSI). The 2018 American Association for the Surgery of Trauma (AAST) Organ Injury Scale incorporates vascular lesions but not hemoperitoneum, which is considered in the Thompson classifier. Granular and verifiable quantitative measurements of these features may have a future role in facilitating objective decision making.

PURPOSE
The purpose of this study is to compare performance of computed tomography (CT) volumetry-based quantitative modeling to the 1994 and 2018 AAST Organ Injury Scale and Thompson classifier for the following endpoints: decision to perform splenectomy (SPY), and the composite of SPY or AE.

MATERIALS AND METHODS
Adult BSI patients (age ≥18 years) scanned with dual-phase CT prior to intervention at a single Level I trauma center from 2017 to 2019 were included in this retrospective study (n = 174). Scoring using 2018 AAST, 1994 AAST, and Thompson systems was performed retrospectively by two radiologists and arbitrated by a third. Endpoints included (1) SPY and (2) the composite of SPY or AE. Logistic regression models were developed from segmented active bleed, contained vascular lesion, splenic parenchymal disruption, and hemoperitoneum volumes. Area under the receiver operating characteristic curve (AUC) for ordinal systems and volumetric models were compared.

RESULTS
Forty-seven BSI patients (27%) underwent SPY, and 87 patients (50%) underwent SPY or AE. Quantitative model AUCs (0.85—SPY, 0.82—composite) were not significantly different from 2018 AAST AUCs (0.81, 0.88, p = 0.66, 0.14) for both endpoints and were significantly improved over Thompson scoring (0.76, p = 0.02; 0.77, p = 0.04).

CONCLUSION
Quantitative CT volumetry can be used to model intervention for BSI with accuracy comparable to 2018 AAST scoring and significantly higher than Thompson scoring.

LEVEL OF EVIDENCE
Prognostic and Epidemiological; Level IV.
A de novo transcription-dependent TAD boundary underpins critical multiway interactions during antibody class switch recombination
Authors: Costea Julia , Schoeberl Ursula E. , Malzl Daniel , von der Linde Maximilian , Fitz Johanna , Makharova Marina , Goloborodko Anton , Pavri Rushad 
Published: May 2022

ABSTRACTConflicts between transcription and cohesin-mediated loop extrusion can majorly influence 3D chromatin architecture but whether these structural changes affect biological function is unknown. Here, we show that a critical step in antibody class switch recombination (CSR) in activated B cells, namely, the juxtaposition (synapsis) of donor and acceptor switch (S) recombination sequences at the immunoglobulin heavy chain locus (Igh), occurs at the interface of a de novo topologically associating domain (TAD) boundary formed via transcriptional activity at acceptor S regions. Using Tri-C to capture higher-order multiway chromatin conformations, we find that synapsis occurs predominantly in the proximity of distal 3’ CTCF-binding sites and that this multiway conformation is abolished upon downregulation of transcription and loss of the TAD boundary at the acceptor S region. Thus, an insulating de novo TAD boundary created by the conflict between transcription and loop extrusion plays a direct role in the mechanism of CSR.
Decreased cerebral blood flow in non-hospitalized adults who self-isolated due to COVID-19
Authors: Kim William S.H. , Ji Xiang , Roudaia Eugenie , Chen J. Jean , Gilboa Asaf , Sekuler Allison , Gao Fuqiang , Lin Zhongmin , Jegatheesan Aravinthan , Masellis Mario , Goubran Maged , Rabin Jennifer S. , Lam Benjamin , Cheng Ivy , Fowler Robert , Heyn Chris , Black Sandra E. , Graham Simon J. , MacIntosh Bradley J. 
Published: May 2022

AbstractThe long-term consequences of coronavirus disease 2019 (COVID-19) on brain physiology and function are not yet well understood. From the recently described NeuroCOVID-19 study, we examined cerebral blood flow (CBF) in 50 participants recruited to one of two groups: 1) adults who previously self-isolated at home due to COVID-19 (n = 39; 116.5 ± 62.2 days since positive diagnosis), or 2) controls who experienced flu-like symptoms but had a negative COVID-19 diagnosis (n = 11). Participants underwent arterial spin labeling magnetic resonance imaging at 3 T to yield measures of CBF. Voxel-wise analyses of CBF were performed to assess for between-group differences, after controlling for age and sex. Relative to controls, the COVID-19 group exhibited decreased CBF in the thalamus, orbitofrontal cortex, and regions of the basal ganglia. Within the COVID-19 group, CBF differences in occipital and parietal regions were observed between those with (n = 11) and without (n = 28) self-reported on-going fatigue. These results suggest long-term changes in brain physiology in adults across the post-COVID-19 timeframe. Moreover, CBF may aid in understanding the heterogeneous symptoms of the post-COVID-19 condition. Future longitudinal studies are needed to further characterize the consequences of COVID-19 on the brain.
A quasi-experimental evaluation of a financial incentive for first-dose COVID-19 vaccination among adults aged ≥ 60 years in South Africa
Authors: Chetty-Makkan Candice M , Thirumurthy Harsha , Bair Elizabeth F , Bokolo Simamkele , Day Candy , Wapenaar Korstiaan , Werner Jesse , Long Lawrence , Maughan-Brown Brendan , Miot Jacqui , Pascoe Sophie J S , Buttenheim Alison M 
Published: May 2022

AbstractIntroductionCOVID-19 vaccination coverage in South Africa (RSA) remains low despite increased access to vaccines. On November 1, 2021, RSA introduced the Vooma Voucher program which provided a small guaranteed financial incentive, a Vooma Voucher redeemable at grocery stores, for COVID-19 vaccination among older adults, a population most vulnerable to serious illness, hospitalization, and death. However, the association of financial incentives with vaccination coverage remains unclear.MethodsWe evaluated the association of the conditional economic incentive program with first-dose vaccination rates among adults (aged ≥60 years) through a quasi-experimental cohort study. The Vooma Voucher program was a nationwide vaccination incentive program implemented for adults aged ≥60 years from November 1, 2021 to February 28, 2022. We ran interrupted time series models to evaluate the Vooma Voucher program at national and provincial levels. We used data between October 1, 2021 and November 27, 2021 in models estimated at the daily level. Individuals who received their first vaccine dose received a text message to access a ZAR100 ($∼7) voucher that was redeemable at grocery stores.ResultsThe Vooma Voucher program was associated with a 7.15-12.01% increase in daily first-dose vaccinations in November 2021 compared to late October 2021. Overall, the incentive accounted for 6,476-10,874 additional first vaccine doses from November 1-27, 2021, or 8.31-13.95% of all doses administered to those aged ≥60 years during that period. This result is robust to the inclusion of controls for the number of active vaccine delivery sites and for the nationwide Vooma vaccination weekend initiative (November 12-14), both of which also increased vaccinations through expanded access to vaccines and demand creation activities.ConclusionsFinancial incentives for COVID-19 vaccination led to a modest increase in first dose vaccinations among older adults in RSA. Financial incentives and expanded access to vaccines may result in higher vaccination coverage.Trial registration number (SANCTR)DOH-27-012022-9116Key points (3-5 sentences)What is already known about this topic?There is a lack of evidence on whether financial incentives for COVID-19 vaccinations are effective in low- and middle-income countries.What does this study add?We found that a ZAR100 (∼US$7) incentive for adults aged ≥60 years increased additional first vaccine doses between November 1-27, 2021 to those aged ≥60 years during that period.How this study might affect research, practice or policy?Small guaranteed financial incentives may be an effective strategy to increase vaccine demand among older adults in low- and middle-income countries.
The effects of topic familiarity on college students' learning search process
Authors: Chen Yijin , Qiu Yue , Lin Hanming , Zhao Yiming 
Published: May 2022

PurposeThis study aims to explore the influence of topic familiarity on the four stages of college students' learning search process.Design/methodology/approachThis study clarified the effects of topic familiarity on students' learning search process by conducting a simulation experiment based on query formulation, information item selection, information sources and learning output.FindingsThe results characterized users' interaction behaviors in increasing topic familiarity through their use of more task descriptions as queries, increased reformulation of queries, construction of more purposeful query formulation, reduced attention to a topic's basic concept content and increased exploration of academic platform contents.Originality/valueThis study proposed three innovative indicators which were proposed to evaluate the effects of topic familiarity on college students' learning search process, and the adopted metrics were useful for observing differences in college students' learning output as their topic familiarity increased. It contributes to the understanding of a user's search process and learning output to support the optimization function of learning-related information search systems and improve their effect on the user's search process for learning.
Exploring consumer purchase intention in cross-border e-commerce: evidence from ‘belt and road’ countries
Authors: Jian Jie , Lv Ling , Wan Li 
Published: May 2022

PurposeThe purpose of this paper is to explore the determinants of consumer purchase intention (CPI) of cross-border e-commerce (CBEC) in the countries of the Belt and Road Initiative (BRI).Design/methodology/approachThis study proposes a research model of the antecedents of CPI on CBEC in BRI countries. Study participants were consumers with CBEC shopping experience in BRI-associated countries (n = 278). Structural equation modeling was used to test the research model.FindingsTrust has the greatest effect on CPI, while perceived security has the least effect. In addition, in BRI-associated countries, in contrast to the previous study, product presentation was found to have a significant positive influence on CPI in CBEC. Platform simplicity and logistic service have a significant positive influence on CPI. Practical implicationsThese findings offer important implications for CBEC. Consumers' trust in product providers has the greatest impact on CPI. Simplicity, timely shipment tracking and the fast delivery speed of the platform will increase CPI. The results suggest a highly successful tactic for enhancing consumers' perceptions of product authenticity and interest. Finally, this study provides insights into BRI. Originality/valueThis study contributes to the literature on CBEC. It explores the multilevel (i.e. product presentation, platform simplicity, logistic service, perceived security, and trust) determinants of CPI on CBEC. The study provides insights into the determinants of CPI in BRI countries.
Local sourcing and MNC subsidiary performance: a legitimacy perspective
Authors: Oki Kiyohiro , Kawai Norifumi 
Published: May 2022

PurposeBased on a legitimacy perspective, this study aims to investigate when local sourcing, as a strategic legitimacy action, improves or impairs subsidiary performance. The authors investigate the moderating role of regulatory/normative institutional distance in the relationship between local sourcing and subsidiary performance. Particularly, departing from prior relevant research, the authors reflect on the direction of institutional distance, categorizing it as either upward or downward institutional distance.Design/methodology/approachUsing Japanese governmental data, this study performs a panel data analysis using a sample of 1,054 Japanese subsidiaries operating in 37 host countries over a 5-year observation period.FindingsThe authors reveal that downward regulatory/normative institutional distance more positively moderates the relationship between local sourcing and subsidiary performance than upward regulatory/normative distance.Originality/valueThere is little research that specifically discusses the performance effects of local sourcing while considering legitimacy concerns. Moreover, the results of analyses of the relationship between local sourcing and subsidiary performance in existing studies are inconsistent, suggesting that it is necessary to identify the boundary conditions under which local sourcing improves or impairs subsidiary performance. To fill these gaps, this study clarifies when local sourcing improves or impairs subsidiary performance based on a legitimacy perspective. The authors’ finding makes a clear contribution to the literature on strategic legitimacy actions and input localization in multinational corporations.
Framework for improving usage of library services and resources in the private higher education in South Africa
Authors: Muzvondiwa Ishewakatipa , Marutha Ngoako Solomon 
Published: May 2022

Purpose
This study aims to investigate a framework for improving library services and resource usage in a private higher education institution in South Africa. Marketing of library services and resources has a great impact on their usage. If marketing is not properly applied, libraries can turn into the unused institution, render useless or unused services, no matter how good their available services and resources are.

Design/methodology/approach
This multi-method study used questionnaires to collect data from both staff and students at the private higher education institution concerned. The questionnaire was augmented with data collected from staff using group interviews. It is unfortunate that the target institution approved the conducting of the study only on the condition that their name could not be disclosed or used in any study reports. On this basis, the institution is referred to as Campus A for the purposes of this paper.

Findings
The study discovered that Campus A lacked key marketing tools, such as a marketing policy for the library, and that it also failed to take advantage of new platforms such as social media and other available computer software and technologies. This has resulted in its users being unaware of certain important services and resources rendered by the library.

Originality/value
The study proposed a framework for library marketing practices to improve services and resources usage as a benchmark for libraries. The study also recommends that the management of Campus A library come together to gather information for the development of an appropriate library marketing policy and also ensure that their marketing strategies take advantage of the latest technology, including social media, by means of which their clients may be easily reached.
H-BIM applications for vernacular architecture: a historic rural house case study in Bursa, Turkey
Authors: Savaşkan Mustafa Onur , Özener Ozan Önder 
Published: May 2022

PurposeThis article presents a case study on the Heritage Building Information Modeling (H-BIM) application in a historic village in Bursa, Turkey. The study addresses how tailor-made and highly structured H-BIM approaches can effectively be implemented in preservation applications for historic vernacular buildings in the rural architecture context.Design/methodology/approachUsing inexpensive digital photogrammetry techniques tightly combined with an object-oriented BIM ontology, parametric meta-modeling and object/system propagation methods, the study employed a holistic H-BIM approach for capturing the materiality, building object behaviors and indigenous construction principles of a characteristic vernacular house that were synthesized in a parametric H-BIM model. The followed stages, steps and connected methods were systematized and articulated in a prototypical H-BIM implementation framework.FindingsThe study findings suggested that the developed parametric H-BIM approach can return effective results with the combined use of low-cost and practical digital photogrammetry with BIM methods. The flexibility and adaptability of the parametric H-BIM implementation framework facilitated the synthesis of a comprehensive H-BIM model and allowed an in-depth evaluation of local architectural heritage with its physical, spatial and environmental characteristics. The proposed H-BIM approach also provided significant documentation and system-specific assessment benefits for preserving the vernacular examples which are prone to extinction especially due to structural and systemic deterioration.Originality/valueThe study proposes a feasible, practical and replicable H-BIM implementation methodology for vernacular preservation applications. The knowledge-embedded H-BIM approach, flows and techniques presented in this study provide a holistic and systematic H-BIM framework – with the integrated use of digital photogrammetry and parametric meta-modeling methods – that has the potential for the democratization of H-BIM applications in education and practice.
Appropriately organized work and employees' concerns related to work from home during the COVID-19 pandemic: the case in Slovenia
Authors: Rožman Maja , Čančer Vesna 
Published: May 2022

PurposeThe main aim of the paper is to establish the effects of appropriately organized work as well as the effects of the employees' concerns related to work during the COVID-19 pandemic on work efficiency and work satisfaction among employees working from home during this period. The empirical research includes 619 employees in Slovenia, who participated in the survey during the COVID-19 pandemic.Design/methodology/approachStructural equation modeling was used in exploring the effects between constructs.FindingsBased on the results, the authors found that appropriately organized work during the COVID-19 pandemic has a positive effect not only on the work efficiency of employees who work from home during the COVID-19 pandemic in Slovenia but also on their work satisfaction. Also, based on the results, the authors found that the employees' concerns related to work during the COVID-19 pandemic have a negative effect on the work efficiency and on the work satisfaction of employees who work from home during this period in Slovenia.Originality/valueThe COVID-19 pandemic dramatically changed the way we live and work; therefore, this paper contributes to the creation of new working conditions and employee management during and also after the COVID-19 pandemic.