bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gastroprotective Agents for the Prevention of NSAID-Induced Gastropathy
Authors: Ares Jeffrey J. , Outt Pamela E. 
Published: October 2022

Abstract:
Over 30 million people in the world take non-steroidal anti-inflammatory drugs (NSAID's). A large percentage of these individuals will develop gastric ulcers and related complications, a condition known as "NSAID gastropathy". NSAID gastropathy differs from classic peptic ulcer disease in many ways, and traditional peptic ulcer therapy is largely ineffective in preventing NSAID-induced gastropathy. The prostaglandin misoprostol has been shown to be effective and is approved for the prevention of NSAID gastropathy. However, misoprostol has side effects that limit its general use. For this
reason, considerable effort throughout the 1990's has focused on the identification of new gastroprotective molecules. Some synthetic •studies have been aimed at the preparation of new prostaglandins, prostacyclin mimetics, and thromboxane antagonists. New histamine H2 receptor antagonists have also been developed which, unlike cimetidine or ranitidine, now appear to couple true gastroprotective activity with antisecretory properties. One new H2 antagonist, ebrotidine, has shown clinical utility in preventing NSAID gastropathy. Many other types of structures (flavonoids, peptides, terpenoids, xanthines, others), as well as compounds displaying certain pharmacological actions (5-hydroxytryptamine receptor binding, adrenergic receptor binding, mast cell stabilization, others) have been linked in some way to gastroprotection. This article reviews many of these recent gastroprotection findings, with emphasis on those of potential use for prevention of NSAID gastropathy.
The Interaction between Hellenic and Persian Pharmacology: What's the output?
Authors: Khosravi Azam , Changizi-Ashtiyani Saeed , Amini Saeed 
Published: October 2022

Background:
Pharmacology has always been of utmost significance to Persian and Hellenic ancient scientists and presented their viewpoints in medical texts. The aim is to assess the interaction between Hellenic and Persian pharmacologists and the resulting output.

Methods:
Using descriptive-analytical method, primary Persian sources written by scholars such as Raban Tabari, Rhazes, Avicenna, and Jorjani, and also the works by prominent Greek scholars including Theophrastus, Hippocrates, Dioscorides, and Galen were searched using selected keywords, based on inclusion and exclusion critera, without time limit in domestic and foreign databases. Finally, the PRISMA diagram was drawn.

Results:
Studies show that Persian and Greek doctors have tried to develop the concepts of pharmacology and its applications interactively. In this research, pharmacology in Persian and Greek medical traditions is studied, and their mutual contributions are depicted. The concepts of medicine and pharmacology in Greek and Persian medicine are first analyzed. The reciprocal impacts of these two schools of pharmacology are explored, and at the end, the Persian scholars who have cited Greek scholars in their works are introduced.

Conclusion:
With the expansion of territories, ancient theories from the farthest lands entered the realm, introducing new drugs and ideas, which by the critical approach of the Persian scholars were sometimes modified and developed.
Effectiveness of Gamification in Knee Replacement Rehabilitation: Protocol for a Randomized Controlled Trial With a Qualitative Approach
Authors: Aartolahti Eeva , Janhunen Maarit , Katajapuu Niina , Paloneva Juha , Pamilo Konsta , Oksanen Airi , Keemu Hannes , Karvonen Mikko , Luimula Mika , Korpelainen Raija , Jämsä Timo , Mäkelä Keijo , Heinonen Ari 
Published: October 2022

Background
Exergames can provide encouraging exercise options. Currently, there is limited evidence regarding home-based exergaming in the postoperative phase of total knee replacement (TKR).

Objective
This study aimed to investigate the effects of a 4-month postoperative home-based exergame intervention with an 8-month follow-up on physical function and symptoms among older persons undergoing TKR compared with home exercise using a standard protocol. In addition, a concurrent embedded design of a mixed methods study was used by including a qualitative component within a quantitative study of exergame effects.

Methods
This was a dual-center, nonblinded, two-arm, parallel group randomized controlled trial with an embedded qualitative approach. This study aimed to recruit 100 patients who underwent their first unilateral TKR (aged 60-75 years). Participants were randomized to the exergame or standard home exercise arms. Participants followed a custom-made exergame program independently at their homes daily for 4 months. The primary outcomes at 4 months were function and pain related to the knee using the Oxford Knee Score questionnaire and mobility using the Timed Up and Go test. Other outcomes, in addition to physical function, symptoms, and disability, were game user experience, exercise adherence, physical activity, and satisfaction with the operated knee. Assessments were performed at the preoperative baseline and at 2, 4, and 12 months postoperatively. Exergame adherence was followed from game computers and using a structured diary. Self-reported standard exercise was followed for 4 months of intervention and physical activity was followed for 12 months using a structured diary. Qualitative data on patients’ perspectives on rehabilitation and exergames were collected through laddering interviews at 4 and 12 months.

Results
This study was funded in 2018. Data collection began in 2019 and was completed in January 2022. The COVID-19 pandemic caused an unavoidable situation in the study for recruitment, data collection, and statistical analysis. As of November 2020, a total of 52 participants had been enrolled in the study. Primary results are expected to be published by the end of 2022.

Conclusions
Our study provides new knowledge on the effects of postoperative exergame intervention among older patients with TKR. In addition, this study provides a new understanding of gamified postoperative rehabilitation, home exercise adherence, physical function, and physical activity among older adults undergoing TKR.

Trial Registration
ClinicalTrials.gov NCT03717727; https://clinicaltrials.gov/ct2/show/NCT03717727

International Registered Report Identifier (IRRID)
RR1-10.2196/38434
FDA Regulatory Implications for Co-crystals and recent Co-crystal Patents
Authors: Samuel Rigilin  , Kunjal Krishnananda Kamath , Thayyil Abdul Raheem , Shabaraya Ramakrishna 
Published: October 2022

One of the most crucial stages in the creation of a medicinal product is the characterization of an Active Pharmaceutical Ingredient (API). Unfortunately, not all APIs have the ideal characteristics for medicinal usage. Many freshly discovered active compounds, for example, have low solubility. However, various methods have been developed to change and improve an API's features to get desired physicochemical properties, which is an important tool in formulation development. The production of salt derivatives is a common technique for increasing the solubility of an active chemical. This method, however, has limits because not every API has the qualities to be transformed into a salt. In recent years, a novel engineering approach for creating new API forms with desirable features has been established. The development of pharmaceutical co-crystals is the result of these efforts which allow pharmaceutical companies to customise existing APIs or create new ones with specific properties. Aside from the scientific hurdles that come with developing a pharmaceutical, manufacturers are also faced with regulatory regulations that must be met in order to get approval and access the market. As pharmaceutical co-crystals are a relatively new API, little regulatory guidance for co-crystals has been developed for one of the world's largest pharmaceutical market the United States of America (USA).
This article will look at what regulatory standards must be met in order to employ pharmaceutical co-crystals in generic medications intended for use in the United States. It will also go over which data should be included in the common technical document to justify its existence. In addition to, a brief information of various patents on co-crystals have also been included for better knowledge of the reader.
Stability-Indicating Analytical Method Development and Validation of Thiocolchicoside and Ibuprofen in Tablet Dosage Form by RP-HPLC Method
Authors: Jadhav Ankush P. , Datar Prasanna A. , Kedar Tejashree R. , Kardile Deepak P. 
Published: October 2022

Objective: First time, a simple, specific, accurate and economic stability-indicating reverse phase high performance liquid chromatographic method was reported for the simultaneous estimation of THIO and IBU in tablet dosage form. Method: The method has shown adequate separation of THIO and IBU from their degradation products. Separation was achieved on an Inertsil, 3V ODS C18, 4.6 mm x 250 mm, 5μ column at wavelength of 248 nm, using a mobile phase Methanol: Dist. water (50:50, v/v) in a mode of isocratic elution at a flow rate of 1.0 ml/min. Results: This method results has minimum retention time for THIO and IBU i.e. 2.317 and 1.075 min. correspondingly, which gives fast separations of drugs furthermore both drug combinations are subjected to acidic, base, oxidation, thermal and photolytic stress environment. Thus stressed samples of these drugs are analyzed by the proposed analytical method. Quantitation was achieve with UV detection at 248 nm based on peak area with linear calibration curve at concentration range 100-600 ppm for THIO and 400-2400 ppm for IBU. The LOD's found 2.00 and 0.54 for THIO and IBU in addition to that LOQ's were found to be 6.08 and 1.63 resp. Conclusion: The statistical analysis proved that this novel proposed method was established to be specific, accurate, precise and stability-indicating study do not shows interfering peaks of degrades and excipient. The proposed method is therefore suitable for purpose in quality-control laboratories for quantitative analysis of THIO and IBU drugs individually and in combined dosage form, as it is performed and validated as per ICH Q2 (R1) and Q1A (R2) guideline and it meets to specific acceptance criteria.
Keywords: Thiocolchicoside (THIO), Ibuprofen (IBU), RP-HPLC, Stability-indicating, ICH.
ADMET informatics of Plant Derived n-Hexadecanoic Acid (Palmitic Acid) from ethyl acetate fraction of Moringa oleifera leaf extract
Authors: Krishnaveni K. , Murugan M. , Kalaimathi RV. , Basha AN. , Pallan GA. , Kandeepan C. , Senthilkumar N. , Mathialagan B. , Ramya S. , Jayakumararaj R. , Loganathan T. , Pandiarajan G. , Kaliraj P. , Dhakar Ram Chand 
Published: October 2022

Palmitic Acid (PA) is known to exert multiple fundamental biological functions at cellular and tissue levels and its steady concentration is guaranteed by its endogenous synthesis by DNL. PA has been for a long time negatively represented for its detrimental health effects tailing its essential physiological attributes. PA has been portrayed to serve as a signalling molecule regulating the progression and development of many diseases at molecular level. Controversial data on the association of dietary PA with detrimental health effects has been related to several parameters such as fatty acid/ macronutrient imbalance by altered lipid metabolism, positive energy balance, excessive intake of carbohydrates, imbalance of dietary PA/PUFA, physiopathological conditions, presence of enhanced DNL and sedentary lifestyle. This may result in dyslipidemia, hyperglycemia, increased ectopic fat accumulation and increased inflammatory tone indicating that clear understanding of system based PA metabolism is still lacking. In the present study an attempt has been made to bring out the absorption, distribution, metabolism, elimination and toxicity profile of PA. Results are expected to have some implications in elucidating the molecular mechanisms that regulates pathophysiological events involved in hyperglycemia/ hyperlipidemia-induced complications associated with diabesity and CVD. Besides it may provide a better understanding to identify key molecular targets for therapeutic management of PA induced metabolic disorders.
Keywords: Moringa oleifera; MOLE; Bioactive Secondary Metabolites; ADME/Tox; Natural Products (NPs); PBNPs; PDHA; n-Hexadecanoic Acid (nHDA); Palmitic Acid (PA)
Combination of Foot Massage and Compression Stocking (EDEFOCS) for Women with Edema in Pregnancy is Feasible Option
Authors: Hevrialni Rully 
Published: October 2022

Edema in pregnancy often occurs. Nearly 80% of all pregnancies can occur in leg edema which is a small problem that can provide initial symptoms for various diseases and pathological conditions and can be an indicator of serious chronic disease. Various methods of management to prevent and treat edema in pregnancy are by compression stocking and foot massage. The purpose of this study was to analyze the effect of foot massage and compression stocking on pain intensity and the degree of edema in pregnant women Trimester III. The type of research is quasi experiment and using a pretest-posttest control group design with 3 treatment groups, namely foot massage, compression stocking and a combination of foot massage and compression stocking. The population of this study was all Trimester III pregnant women with edema in Pekanbaru City. The sampling technique used purposive sampling with inclusion criteria. This research was conducted on April 9 to September 15, 2018 in Pekanbaru City Health Center namely Rumbai Health Center, Umbansari Health Center and Melur Health Center. Data analysis using Annova Test. The results showed that in the combination group of foot massage and compression stocking the decrease in the average pain intensity was 1.8 and the decrease in the average degree of edema was 1.6 mm. There is the effect of foot massage, compression stocking and a combination of foot massage and compression stocking on pain intensity and degree of edema (p -value = 0.00. The group that most significantly reduces pain intensity and the degree of edema is a combination of foot massage and compression stocking. Recommended for health workers in order to use the method of foot massage, compression stocking and a combination of foot massage and compression stocking in preventing and reducing edema in pregnant women.
Keywords: Foot massage, compression stocking, Pain intensity, Degree of edema, Third trimester of pregnancy
Rancang Bangun Aplikasi Media Pembelajaran Interaktif Pengenalan Komputer Dan Kuis Pilihan Ganda Berbasis Web
Authors: Permatasari Intan , Nugraha Nunu 
Published: October 2022

Penelitian ini bertujuan untuk merancang dan membangun apalikasi media pembelajaran berbasis flash pada mata pelajaran TIK dengan topik pengenalan komputer. Aplikasi ini dibuat sebagai media pembelajaran bagi siswa kelas XI MTs Al Ma’Mur Ciawigajah. Aplikasi media pembelajaran berbasis flash dapat digunakan sebagai salah satu alternatif media pembelajaran bagi siswa. Metode yang digunakan dalam merancang dan membangun aplikasi menggunakaan metode waterfall, terdiri dari lima tahap yaitu Requirement Analisis, System Design, Implementation, Integration Testing dan Operation Maintenance. Berdasarkan hasil implementasi dan pengujian aplikasi, bahwa aplikasi dapat berjalan dengan baik sesuai dengan spesifikasi yang dibutuhkan, dan dapat digunakan sebagai media pembelajaran siswa. Fitur kuis yang terdapat pada aplikasi pembelajaran dapat digunakan sebagai bahan evaluasi bagi guru dalam memberikan penilaian hasil belajar siswa. Kata kunci : Media, Pembelajaran, Flash, Komputer, Aplikasi
Investigator's Intuition: Conditions of Formation and the Possibility of Implementation of Artificial Intelligence
Authors: Tsvetkova Anna Denisovna 
Published: October 2022

The paper examines the issues of intuition in investigative practice. Relying on the positions of prominent forensic scientists, the importance of this heuristic mechanism for overcoming deadlocks caused not only by a shortage of information, but also by its overabundance is substantiated. The author suggests mechanisms for the development of intuition, the main of which is called the expansion of erudition, the accumulation of a large number of background knowledge. The second part of the article discusses the problems of artificial intelligence. Firstly, the topic of its potential to replace a person is covered. Secondly, the position existing in science is refuted, according to which the work of artificial neural networks is characterized as intuitive. Based on the analysis of practical examples and the synthesis of various scientific positions, the author formulated the following conclusions: 1. The intuitive decisions based on the probabilistic assumption assist the investigator in choosing specific investigative actions or tactics for their conduct. 2. Intuition is best developed among investigators with average work experience and broad erudition. 3. Intuition can and should be developed, mainly by expanding erudition, accumulating background experience. 4. The work of artificial neural networks cannot be called completely intuitive, since they act according to a given algorithm, even if generating a solution that is not accessible to human perception, whereas intuition is a creative process that goes beyond standard models. 5. To date, there is only a weak artificial intelligence, which is able to cover only situations of an overabundance of information, but not its deficit, although the latter very often require an appeal to intuition. 6. Intuition is a competitive advantage of humans over artificial intelligence, allowing our species to think more broadly, more versatile.
PRODUCTIVE DISPOAITION DITINJAU DARI KEMAMPUAN SISWA DALAM MENYELESAIKAN SOAL CERITA PADA MATERI PERBANDINGAN
Authors: Asmiyati Delta Minanti , Jamiah Yulis , B. Diah Ahmad 
Published: October 2022

Abstract This research is aimed to determine student productive disposition in terms of students' ability in solving story problems on the comparison material in Mts Negeri 1 Pontianak. The research method used was descriptive with a typical study research form. The sample of this research were students of class VII MTs Negeri 1 Pontianak which were taken as many as 4 students who have high ability in solving story questions and 4 students with low ability in solving story questions. Data collection techniques used in this study was test questions, questionnaires and interviews. Data were analyzed using SPSS 25.0 for windows. The results of the questionnaire show that students who have high productive disposition students have high productive disposition, while students who have low ability to solve story questions where 1 student has high productive disposition, 2 medium students and 1 low student. Keywords: Comparison Material, Productive disposition, Student Abilities
Avistamiento del mosquero garganta blanca (Empidonax albigularis) en el Distrito Federal, México
Authors: Gómez de Silva Garza Héctor , Oliveras de Ita Adán 
Published: October 2022

Sólo existe un registro de Empidonax albigularis para el Distrito Federal, México. Aquí reportamos tres registros más para la zona y uno para la parte adyacente del estado de Morelos.
VIDEO SYUR MIRIP GISELLA DALAM PERSPEKTIF ISLAM DI INDONESIA
Authors: Nurhuda Abid 
Published: October 2022

The media is a tool for disseminating information and news to the public. In addition, it is also used as a means of entertainment by the community so that various managers compete with each other to lure the public to become the most favorite media. But sometimes it is done with things that are not praiseworthy, such as showing pictures, videos or films that contain pornographic elements. Regarding this, the last few weeks of November, which were presented by the media, especially in the virtual universe, Twitter and which became a trending topic, were exciting videos similar to Gisella which caused pros and cons among the community. Exciting videos similar to gisella are a form of pornography and in the view of Islam, all those who are involved intentionally get reward / sin and the reward is the audience, the creator, the perpetrator, and the spreader. Meanwhile, the laws in Indonesia that are entangled with laws are the perpetrators, the creators or the disseminators of the video, either with the Pornography Law or the ITE Law.Media merupakan salah satu alat untuk menyebarkan informasi dan berita kepada masyarakat. Selain itu juga digunakan sebagai sarana hiburan oleh masyarakat sehingga berbagai pihak pengelola saling berlomba-lomba untuk memikat masyarakat agar menjadi media yang paling favorit. Namun terkadang dilakukan dengan hal-hal yang tidak terpuji seperti mempertontonkan gambar, video ataupun film yang mengandung unsur pornografi. Mengenai hal itu, Beberapa minggu terakhir dari bulan november ini yang disuguhkan oleh media khususnya di jagad maya twitter dan menjadi trending topic adalah video syur mirip dengan gisella yang menimbulkan pro dan kontra di kalangan masyarakat. Metode yang dugunakan dalam penelitian ini adalah kualitatif deskriptif yang mana mengumpulkan buku-buku atau referensi yang relevan dan akurat, serta membaca dan mempelajari untuk memperoleh sebuah data atau kesimpulan yang berkaitan dengan pembahasan tersebut diatas dengan melakukan analisis secara perspektif normatif untuk menemukan jawaban. Video syur mirip gisella merupakan bentuk pornografi dan dalam pandangan islam semua yang terlibat dengan sengaja maka mendapat ganjaran/dosa dan balasannya baik penonton, pembuat, pelaku, maupun penyebarnya. Sementara itu hukum di indonesia yang terjerat undang-undang adalah pelaku, pembuat ataupun penyebar video tersebut baik dengan UU Pornografi ataupun UU ITE. Untuk menanggulangi hal tersebut diperlukan 3 peran : Peran individu, Masyarakat dan Negara Indonesia.
Dukungan Jepang terhadap UN Women Terkait Pemberantasan Kekerasan Perempuan Pada Saat Pandemi Co – Vid 19
Authors: MAURA ZALIA SAFA 
Published: October 2022

This research discusses about Japan’s contribution to The United Nations that focused on UN Women in dealing with violence against woman. According data from Un Women’s about violence woman during lockdown , terdapat kenaikan data sebesar 75% during pandemic Co – Vod 19. So for against this problem, UN Women takes some actions for measure against violence woman in Co-Vid 19.Japan, a country that is active in activities to reduce violence against women in activities carried out by UN Women, has also actively contributed to preventing women's violence during the Co-Vid 19 pandemic. Japan’s promotion about “Human Security” for global is expected to be able and attract sympathies from others countries in the world and they will firm in making policies regarding human security especially protection of women in their country.. with this situation, Japan contributes to other countries whose societies are affected by violence against women during co-vids 19.Penelitian ini membahas tentang kontribusi Jepang terhadap PBB yang berfokus pada UN Women dalam menangani kekerasan terhadap perempuan. Menurut data dari Un Women tentang kekerasan perempuan saat lockdown, terdapat kenaikan data sebesar 75% selama pandemi Co – Vod 19. Maka untuk mengatasi masalah ini, UN Women mengambil beberapa tindakan untuk tindakan terhadap kekerasan perempuan di Co-Vid 19.Japan, sebuah negara yang aktif dalam kegiatan pengurangan kekerasan terhadap perempuan dalam kegiatan yang dilakukan oleh UN Women, juga aktif berkontribusi dalam pencegahan kekerasan terhadap perempuan di masa pandemi Co-Vid 19. Promosi Jepang tentang “Human Security” secara global diharapkan dapat menarik simpati dari negara-negara lain di dunia dan mereka akan tegas dalam membuat kebijakan mengenai keamanan manusia khususnya perlindungan perempuan di negara mereka. negara yang masyarakatnya terkena dampak kekerasan terhadap perempuan selama covid 19.