bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simple and effective screening strategy for early multiple system atrophy diagnosis and α-Synuclein forms in erythrocytes
Authors: Jiang Ying , Jin Jianing , Piao Yingshan , Yin Yixuan , Tang Lian , Guan Qixuan , Gao Yang , Feng Tao , Wang Zhan 
Published: February 2025

BackgroundUrinary dysfunction is an early manifestation of autonomic dysfunction in Multiple System Atrophy (MSA) and often precedes orthostatic hypotension. This study investigated the diagnostic efficacy of post-void residual (PVR) urine volume in differentiating possible MSA from early-stage Parkinson’s disease (PD) and sought to identify a feasible combination of autonomic nervous system indicators for clinical use. The distribution of α-Synuclein (α-Syn) forms in erythrocyte was preliminary explored.MethodsThis study included 70 patients with MSA-P, 73 with MSA-C, and 71 with PD. All participants underwent assessments including bladder residual urine ultrasound, the supine-to-standing test (STS), external anal sphincter electromyography (EAS-EMG), brain MRI, Mini-Mental State Examination (MMSE), and Montreal Cognitive Assessment (MoCA). Receiver operating characteristic (ROC) curves determined the diagnostic value of PVR urine volume and other autonomic indicators for possible MSA. Immunofluorescence staining of α-Syn forms in red blood cells (RBCs) was also performed.ResultsPVR urine volume, ΔSBP and ΔDBP (at 1 and 3 min), and EAS-EMG parameters were significantly increased in MSA-P and MSA-C patients compared to PD (p &lt; 0.01), with similar differences observed between possible MSA-P/MSA-C and early-stage PD patients. ROC analysis showed that PVR urine volume had diagnostic value in differentiating possible MSA-P (AUC = 0.668, cut-off 24.5 mL) and MSA-C (AUC = 0.759, cut-off 47.5 mL) form early-stage PD patients. ΔSBP at 1 and 3 min also distinguished possible MSA-P (AUC = 0.702, 0.730) and MSA-C (AUC = 0.707, 0.718) from early-stage PD. Combining PVR urine volume and ΔSBP (at 1 and 3 min) further improved diagnostic accuracy, with an AUC of 0.817 (sensitivity 57.1%, specificity 96.8%) for possible MSA-P and an AUC of 0.794 (sensitivity 68.6%, specificity 87.1%) for MSA-C from early-stage PD. On a molecular level, oligo-α-Syn predominantly localized to RBC membrane fractions in MSA patients, while α-Syn pS129 was primarily detected in the RBC cytoplasm of PD patients.ConclusionCombining PVR urine volume and ΔSBP (at 1 and 3 min) is an easily accessible and effective method for distinguishing possible MSA from early-stage PD. This combination should be considered for routine assessment in Parkinsonism. Distinct α-Syn forms distribution in erythrocytes could be considered as a useful biomarker for differential diagnosis.
Effects of happy sensation training group on the symptom of anxiety, depression and sleep structure: a randomized controlled trial
Authors: Yan Deping , Wang Yunqiong , Li Jia , Wang Ling , Yao Yongping , Deng Jing 
Published: February 2025

BackgroundNon-drug therapy is a common clinical treatment for chronic insomnia, and the effect of happiness perception training group based on five senses therapy on chronic insomnia has not been evaluated.ObjectiveThis study investigated the effects of happy sensation training group on anxiety, depression and insomnia symptoms in patients with chronic insomnia disorder.MethodsA prospective, assessor-blind, randomized controlled design was used. Adult patients with chronic insomnia were recruited from the Sleep Medicine Center of Sichuan Provincial Center for Mental Health. Participants in the training group received 10 sessions of hospital-based happy sensation training group therapy and three months of home exercises. The control group received health instruction. Results included anxiety, depression, and insomnia and were assessed at baseline, 2-week intervention, and 3-month follow-up. Polysomnography was performed at baseline and 2-week intervention. Two-way repeated measure ANOVA and Nonparametric test were used for data analysis.Results42 patients in the training group and 43 patients in the control group accomplished 3-month follow-up. There was no significant difference in anxiety, depression, insomnia and sleep Characteristics between training group and control group at baseline (P &gt; 0.05). Compared with the control group, anxiety, depression and insomnia were improved in the training group after 2 weeks and at the 3-month follow-up (P &lt; 0.05), sleep latency was shortened (P &lt; 0.001), and sleep efficiency, total sleep time and N2 phase sleep were increased (P &lt; 0.05).ConclusionHappiness sensation training group can effectively improve the anxiety and depression of chronic insomnia patients, so as to improve insomnia. Given its acceptability and practicality, the program could be incorporated into routine treatment.Clinical trial registrationhttps://www.chictr.org.cn/bin/project/edit?pid=210919, identifier ChiCTR2400082199.
Exploration of risk factors and characteristics of COVID-19 infection among patients with hematological malignancies in Suzhou, China: a retrospective study
Authors: Yao Yao , Di Wenjuan , He Fangkai , Liu Bin , Chen Xue , Guan Xiaojun , Huang Zhou , Wang Ying , Wu Depei 
Published: February 2025

Background and aimPatients diagnosed with cancer, particularly those with hematologic malignancies, frequently exhibit a state of immunosuppression. Currently, there remains a scarcity of dependable biomarkers for assessing the severity of COVID-19 in individuals with hematologic malignancies. We conducted a retrospective study of morbidity and mortality in patients with hematological malignancies (HM) who had contracted COVID-19. The aim was to offer a reference for clinical diagnosis and treatment.MethodsA total of 71 patients with HM-confirmed COVID-19 were enrolled from December 2022 to May 2023. Clinical symptoms, laboratory findings, and treatment approaches were collected and documented. Patients were classified into survival and death groups based on their COVID-19 outcomes, and statistical analysis was performed on the clinical data from both groups.ResultsAmong the 71 patients, 57 (80.3%) were alive, and 14 (19.7%) had died. The mean age of patients in the death group was significantly higher than that of the survival group (51.29 ± 20.76 vs. 49.47 ± 13.04, P=0.030). The proportion of patients receiving mechanical ventilation was significantly higher in the death group (P&lt;0.001). The mortality rate was significantly higher in the critically severe group compared to the mild, moderate, and severe groups (P&lt;0.001). Correlation analysis revealed that certain laboratory indicators lactic acid dehydrogenase (LDH), albumin (ALB), creatine kinase (CK), troponin T (TnT), N-terminal pro-brain natriuretic peptide (NT-proBNP) and fibrin degradation product (FDP), which exhibited significant differences between groups, were significantly correlated with COVID-19-related mortality (all P&lt;0.05). The Cox proportional hazards model indicated that LDH was an independent risk factor associated with the prognosis of HM-confirmed COVID-19.ConclusionPatients with hematologic malignancies suffer severe morbidity and mortality due to COVID-19 infection. LDH may serve as a risk factor associated with prognosis in the treatment of COVID-19. Monitoring variations in LDH levels can assist healthcare providers in evaluating disease progression, adjusting treatment plans in a timely manner, and predicting patient outcomes.
Predicting new-onset stroke with machine learning: development of a model integrating traditional Chinese and western medicine
Authors: Wang Liuding , Shi Jingzi , Miao Lina , Chen Yifan , Wei Jingjing , Jia Min , Gong Zhiyi , Yang Ze , Lyu Jian , Zhang Yunling , Liang Xiao 
Published: February 2025

IntroductionThe integration of traditional Chinese medicine (TCM) and Western medicine has demonstrated effectiveness in the primary prevention of stroke. Therefore, our study aims to utilize TCM syndromes alongside conventional risk factors as predictive variables to construct a machine learning model for assessing the risk of new-onset stroke.MethodsWe conducted a ten-year follow-up study encompassing 4,511 participants from multiple Chinese community hospitals. The dependent variable was the occurrence of the new-onset stroke, while independent variables included age, gender, systolic blood pressure (SBP), diabetes, blood lipids, carotid atherosclerosis, smoking status, and TCM syndromes. We developed the models using XGBoost in conjunction with SHapley Additive exPlanations (SHAP) for interpretability, and logistic regression with a nomogram for clinical application.ResultsA total of 1,783 individuals were included (1,248 in the training set and 535 in the validation set), with 110 patients diagnosed with new-onset stroke. The logistic model demonstrated an AUC of 0.746 (95% CI: 0.719–0.774) in the training set and 0.658 (95% CI: 0.572–0.745) in the validation set. The XGBoost model achieved a training set AUC of 0.811 (95% CI: 0.788–0.834) and a validation set AUC of 0.628 (95% CI: 0.537–0.719). SHAP analysis showed that elevated SBP, Fire syndrome in TCM, and carotid atherosclerosis were the three most important features for predicting the new-onset stroke.ConclusionUnder identical traditional risk factors, Chinese residents with Fire syndrome may have a higher risk of new-onset stroke. In high-risk populations for stroke, it is recommended to prioritize the screening and management of hypertension, Fire syndrome, and carotid atherosclerosis. However, future high-performance TCM predictive models require more objective and larger datasets for optimization.
Who gets frustrated? Identifying individuals prone to frustration using a latent profile analysis
Authors: Yazdi Hannaneh , Ljung Aust Mikael , Wickman Casper , Bujacz Aleksandra , Kowalski Leo , Lundström Johan N. 
Published: February 2025

IntroductionFrustration is a complex negative emotion with multifaceted components that significantly influence cognitive and behavioral responses. While previous studies have explored frustration, identifying distinct groups of individuals prone to frustration has yielded inconsistent findings. This study employs a person-centered approach to identify clusters of drivers based on frustration triggers and emotional responses to frustrating events.MethodsA total of 2,219 drivers participated in an online survey assessing frustration experiences in various frustrating scenarios. Latent Profile Analysis (LPA) was conducted to identify subgroups based on frustration triggers and emotional responses. Predictor variables included Driving Behavior Dimensions (violations, errors, and lapses), user group categories (car-sharing, ownership, leasing), and demographic factors (age and gender).ResultsLPA identified four distinct frustration profiles: Minimal, Low, Moderate, and Severe. These profiles were associated with different frustration triggers (i.e., goal blockage, limited control) and emotional responses (i.e., anger, stress, and irritation). The Severe profile, characterized by a high probability of individuals being highly prone to frustration, exhibited the highest frustration levels and was predominantly composed of older drivers (&gt;45 years), particularly women, from car-sharing and leasing user groups. Emotional response patterns and the likelihood of frustration arousal are consistent across profiles, varying primarily in intensity.DiscussionThese findings offer insights into frustration susceptibility and underscore the need for targeted interventions to enhance emotion regulation in driving contexts. Future research should explore personalized strategies to mitigate frustration based on individual and group characteristics.
The impact of core training combined with breathing exercises on individuals with chronic non-specific low back pain
Authors: Li Ying , Zhao Qian , Zhang Xiao , E Yan , Su Yuqin 
Published: February 2025

BackgroundChronic non-specific low back pain (CNLBP) is a common condition, defined as pain lasting more than 3 months between the lower thoracic margin and gluteal folds, without identifiable tissue damage. Despite its low disability rate, the complex etiology and high recurrence impose significant health and socioeconomic burdens. According to European LBP guidelines, exercise therapy is the preferred treatment for CNLBP. This study evaluates the efficacy of core training combined with breathing exercises as a therapeutic intervention for CNLBP.MethodsEighteen CNLBP patients were randomly assigned to three groups: core training only, core training with breathing exercises, and a control group. A 12-week intervention included VAS, ODI scores, and muscle strength tests.ResultsThe combined group showed significantly greater pain reduction, functional improvement, and muscle strength enhancement compared to the other groups.ConclusionCore training with breathing exercises is more effective in alleviating CNLBP symptoms, highlighting the added value of integrating breathing exercises.
Exploring the relationship between physical activity and smartphone addiction among college students in Western China
Authors: Lai Chun , Cai Peiling , Liao Junyi , Li Xiwei , Wang Yuanyuan , Wang Mengping , Ye Peng , Chen Xinwei , Hambly Brett D. , Yu Xiaoping , Bao Shisan , Zhang Haifeng 
Published: February 2025

BackgroundSmartphone addiction (SA) refers to a behavioral disorder characterized by an irresistible compulsion to excessively engage with mobile devices. Currently, the evidence regarding the relationship between physical activity (PA), exercise intensity (EI), and SA is limited, particularly within Chinese populations. This study aims to explore the correlation between PA, EI, and SA, specifically investigating how PA and EI impact SA to better understand the nature of this relationship.MethodsA cross-sectional study was conducted involving college students from over 20 universities in Western China. Data were collected on participants’ engagement in PA, EI, and SA. Additionally, covariates such as age, gender, ethnicity, academic classification, university location, discipline, year of study, hometown region, sibling status, relationship status, and social interactions were recorded. Multivariate logistic regression models were used to assess the association between PA, EI, and SA. Stratified and interaction analyses were performed to examine whether the relationship remained consistent across different subgroups.ResultsOf the 3,506 college students surveyed, 1,905 (54.3%) experienced SA. The prevalence of SA was 11.3% lower in the group that engaged in PA compared to those who did not. In the fully adjusted model, PA was negatively associated with SA (OR = 0.70, 95% CI: 0.59–0.82, p &lt; 0.001). EI was also inversely associated with SA. Moderate- and vigorous-intensity exercise had odds ratios of 0.81 (95% CI: 0.67–0.98, p = 0.034) and 0.83 (95% CI: 0.68–1.00, p = 0.046), respectively, compared with low-intensity exercise. Similar patterns were observed in subgroup analyses (all p values for interaction &gt;0.05).ConclusionThe findings indicate a significant negative association between PA, EI, and SA, highlighting the potential of promoting PA and higher EI as strategies to reduce SA among college students.
Biological Activity and Chemical Composition of Essential Oil from Leaves and Fruits of Zanthoxylum mantaro (J.F.Macbr.) J.F.Macbr
Authors: Morocho Vladimir , Eras Odalis , Rojas Teresa , Jiménez Britany , Roa María Fernanda , Cartuche Luis 
Published: February 2025

Objective: In this study, the chemical composition and biological activities of the essential oils extracted from the leaves and fruits of Zanthoxylum mantaro were analyzed. Methods: The essential oils were obtained through hydrodistillation using a Clevenger-type apparatus. Chemical composition was determined by gas chromatography coupled with mass spectrometry (GC-MS) and gas chromatography with a flame ionization detector (GC-FID). The antimicrobial activity was evaluated against four Gram-positive bacteria, three Gram-negative bacteria, and two fungi using the broth microdilution method. Antioxidant activity was assessed using the ABTS (2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid) and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assays. Additionally, the acetylcholinesterase inhibitory effect of the essential oils was measured by a spectrophotometric method. Results and Conclusions: A total of 23 compounds were identified in the essential oil from the fruits, while 47 compounds were found in the essential oil from the leaves. The major constituents of the fruit essential oil were α-thujone (39.85%), β-thujone (25.04%), sabinene (10.71%), and terpinen-4-ol (4.38%), whereas the main compounds in the leaf essential oil were germacrene D (21.75%), nerolidol (E) (12.39%), and pentadecanal (7.14%). The essential oil from the fruits exhibited antifungal activity against Aspergillus niger (ATCC 6275), with a minimum inhibitory concentration (MIC) of 1000 μg/mL. Both the fruit and leaf essential oils showed moderate antioxidant activity in the ABTS assay, with SC50 values of 274.14 ± 1.06 μg/mL and 2798.85 ± 15.69 μg/mL, respectively. Furthermore, the fruit essential oil demonstrated considerable acetylcholinesterase inhibitory activity with an IC50 value of 65.46 ± 1.01 μg/mL, while the leaf essential oil exhibited an IC50 value of 158.2 ± 1.02 μg/mL.
Impact of Teleparallelism on Addressing Current Tensions and Exploring the GW Cosmology
Authors: Mishra Sai Swagat , Kavya N. S. , Sahoo P. K. , Venkatesha V. 
Published: February 2025

Abstract
The H
0 and S
8 tensions highlight critical discrepancies in modern cosmology, challenging the standard Lambda cold dark matter model. The H
0 tension arises from conflicting measurements between local probes and early-Universe predictions. Similarly, the S
8 tension, related to the amplitude of matter clustering, exposes inconsistencies between cosmic microwave background data and weak gravitational lensing surveys. The primary goal of this work is to address these tensions by modifying the underlying geometric framework. Specifically, we test two f(T) gravity models using cosmic chronometers, baryonic acoustic oscillations, gamma-ray bursts, and Pantheon+SH0ES data sets and compare the results with gravitational-wave data for validation. Both teleparallel models demonstrate promising performance in simultaneously alleviating the H
0 and S
8 tensions.
Torsional Alfvén Shock Waves in Stratified Coronal Loops
Authors: Hejazi S. M. , Vasheghani Farahani S. , Hajisharifi K. 
Published: February 2025

Abstract
The evolution of weakly nonlinear Alfvén waves in coronal loops in the density structuring both across and along the field while experiencing dissipation is highlighted. Energy transfer due to shock formation in coronal loops provides the basis for the context of the present study. Coronal loops are modeled analytically using the magnetohydrodynamic (MHD) theory in cylindrical geometry, incorporating stratification and viscosity. The effects of the external medium, along with equilibrium conditions, are considered, with the background magnetic field aligned parallel to the loop axis. The second-order thin flux tube approximation is employed to derive a Cohen–Kulsrud–Burgers type of evolutionary equation that highlights the influences of nonlinear, dissipative, and stratification terms, alongside the effect of the external medium. The Alfvén wave speed in coronal loops reaches its maximum when shocks are experienced. If not due to low amplitudes, the maximum is observed at the other footpoint. The location of shock formation is determined by the ratio of the Alfvén wave amplitude and the background Alfvén wave speed. The existence of energy transfer mechanisms due to MHD shocks at various locations of coronal loops, especially loop footpoints, brings to mind that observed energy transfers in the case of coronal loops or a set of loops not only provide coronal heating but also provide transition region heating subject to conditions. For high plasma-β values at lower altitudes, shock formation is less dependent on the external medium and depends strongly on the loop’s internal dynamics. This is contrary to open magnetic structures.
Dataset of Grey plover (Pluvialis squatarola) diet composition on the SW Black Sea coast using DNA metabarcoding
Authors: Vassileva Liliana , Lozanova Lyudmila , Marinov Martin , Morinière Jérôme , Neov Boyko , Nikolov Boris , Simov Nikolay , Klayn Stefania 
Published: February 2025

Food quality and availability at migration stopover sites is crucial for wader migration success, particularly nowadays with their populations in decline due to widespread anthropogenic habitat degradation and loss.
We studied the diet composition and preferences of the Grey plover (Pluvialis squatarola) at a stopover site on the Black Sea-Meditteranean Flyway - Pomorie Lake, SW Black Sea coast, Bulgaria, - through DNA metabarcoding of faeces. The study aimed to determine the bird's feeding strategy, coastal habitat use, and possible seasonal variations as a result of local prey availability.
The dataset includes new data on Grey plover (Pluvialis squatarola) prey items on the south-western Black Sea coast, Bulgaria. The diet composition data provides valuable insights on coastal biodiversity in the area as "sampled" by this generalist invertivore, and contributes to the knowledge of Grey plover prey choice and habitat use in a little-studied microtidal marine region.
Quelle place pour le captage et le stockage géologique de carbone dans la stratégie de décarbonation française ? Débats et promesses autour de l’avis de l’Ademe de 2020
Authors: Marchand Guillaume , Chailleux Sébastien 
Published: February 2025

Les technologies de captage et de stockage géologique de carbone (csc) s’inscrivent pleinement dans l’idéal de modernisation écologique, puisqu’elles devraient permettre de mettre en œuvre une transition écologique plus douce, ne nécessitant pas de transformation profonde des comportements et de l’appareil productif et pouvant offrir des pistes de reconversion à l’industrie pétrolière et gazière. Après une période de relative difficulté au cours des années 2010, les technologies de captage et de stockage géologique du carbone ont opéré un retour à la fin de cette décennie dans les agendas politiques et les stratégies industrielles européennes liés à la transition écologique. Cependant, en juillet 2020, l’Ademe a publié un avis technique pointant le potentiel limité de cette technologie pour la décarbonation de l’économie française. Nous nous intéressons dans cet article à la façon dont les principaux promoteurs de cette technologie ont reçu cet avis et les échanges qu’il a générés au sein de cette coalition. En nous appuyant sur l’économie des promesses technoscientifiques, nous mettons en avant trois fragilités du discours de promotion du csc que la note de l’Ademe donne à voir : 1) une fragilité de la crédibilité scientifique à travers un désalignement des acteurs au sein de la coalition et la mise en avant d’incertitudes ; 2) une fragilité de l’horizon des attentes entre un gouvernement français qui voit dans le csc un outil marginal et des acteurs industriels, en particulier pétrogaziers, qui en font un instrument plus central dans la transition énergétique ; 3) une fragilité dans le soutien politique et industriel que la marginalité de la solution fait peser sur la filière.