bluuebunny/crossref_metadata_2025_split huggingface dataset:
Holmium laser enucleation of the prostate in men on active surveillance for prostate cancer with refractory lower urinary tract symptoms secondary to enlarged prostates
Authors: Schober Jared P. , Stensland Kristian D. , Moinzadeh Alireza , Canes David , Mandeville Jessica 
Published: September 2022

AbstractIntroductionThe surgical treatment of men with lower urinary tract symptoms (LUTS) and significantly enlarged symptomatic prostates on active surveillance (AS) for low‐risk prostate cancer (PCa) is not well defined. We report our single‐institution initial experience with holmium laser enucleation of the prostate (HoLEP) for LUTS in men with low‐risk PCa being managed with AS.Materials and MethodsMen on AS who underwent HoLEP between 2013 and 2019 were identified. Data regarding preoperative cancer workup, prostate‐specific antigen (PSA), perioperative outcomes, and voiding parameters were analyzed. Postoperative surveillance for PCa including PSA nadir, prostate magnetic resonance imaging, prostate biopsy (PBx), and PSA at last follow‐up were evaluated.ResultsTwenty men met the inclusion criteria. Preoperative mean max flow 7.9 ml/s, median postvoid residual 101 cc, and mean transrectal ultrasound prostate size 99 cc. Patients had a median adjusted preoperative PSA of 8.5 (interquartile range [IQR]: 4.8–13.2) ng/ml. Mean resected tissue weight was 65.5 g with improved postoperative flow rate and significantly decreased residual. A total of 5/20 men had PCa in the specimen (all Gleason Grade Group 1). The median postoperative PSA nadir was 1.2 (IQR: 0.5–1.8) ng/ml at median of 5 months. At the last follow‐up (median 18.5 months, IQR: 10.5–37.8), the median postoperative PSA was 1.4 (IQR: 0.63–2.48) ng/ml. Nine men underwent postoperative multiparametric magnetic resonance imaging (mpMRI) with the identification of a new prostate imaging reporting and data system 5 lesion in one patient who underwent negative fusion biopsy. Five men underwent post‐HoLEP PBx with progression in two patients, who both successfully underwent radical prostatectomy.ConclusionsMen on AS for low‐risk PCa can safely undergo HoLEP with significantly improved voiding parameters. Postoperative monitoring with PSA, mpMRI, and PBx can detect disease progression requiring definitive treatment. Further research is needed to optimize surveillance strategies and long‐term cancer‐specific outcomes.
Prostate cancer aggressiveness and financial toxicity among prostate cancer patients
Authors: KC Madhav , Oral Evrim , Rung Ariane L. , Trapido Edward , Rozek Laura S. , Fontham Elizabeth T. H. , Bensen Jeannette T. , Farnan Laura , Steck Susan E. , Song Lixin , Mohler James L. , Khan Saira , Vohra Sanah , Peters Edward S. 
Published: September 2022

AbstractIntroductionFinancial toxicity (FT) is a growing concern among cancer survivors that adversely affects the quality of life and survival. Individuals diagnosed with aggressive cancers are often at a greater risk of experiencing FT. The objectives of this study were to estimate FT among prostate cancer (PCa) survivors after 10−15 years of diagnosis, assess the relationship between PCa aggressiveness at diagnosis and FT, and examine whether current cancer treatment status mediates the relationship between PCa aggressiveness and FT.MethodsPCa patients enrolled in the North Carolina‐Louisiana Prostate Cancer Project (PCaP) were recontacted for long‐term follow‐up. The prevalence of FT in the PCaP cohort was estimated. FT was estimated using the COmprehensive Score for Financial Toxicity, a validated measure of FT. The direct effect of PCa aggressiveness and an indirect effect through current cancer treatment on FT was examined using causal mediation analysis.ResultsMore than one‐third of PCa patients reported experiencing FT. PCa aggressiveness was significantly independently associated with high FT; high aggressive PCa at diagnosis had more than twice the risk of experiencing FT than those with low or intermediate aggressive PCa (adjusted odds ratio [aOR] = 2.13, 95% CI = 1.14−3.96). The proportion of the effect of PCa aggressiveness on FT, mediated by treatment status, was 10%, however, the adjusted odds ratio did not indicate significant evidence of mediation by treatment status (aOR = 1.05, 95% CI = 0.95−1.20).ConclusionsAggressive PCa was associated with high FT. Future studies should collect more information about the characteristics of men with high FT and identify additional risk factors of FT.
Calycosin protects against oxidative stress‐induced cardiomyocyte apoptosis by activating aldehyde dehydrogenase 2
Authors: Ding Wen‐jun , Chen Guang‐hong , Deng Sui‐hui , Zeng Ke‐feng , Lin Kai‐li , Deng Bo , Zhang Shuang‐wei , Tan Zhang‐Bin , Xu You‐cai , Chen Si , Chen Jun‐bang , Chen Ting‐fang , Tan Yong‐zhen , Zhou Ying‐chun , Zhang Jing‐zhi , Liu Bin 
Published: September 2022

AbstractMyocardial infarction (MI) is the leading cause of death worldwide, and oxidative stress is part of the process that causes MI. Calycosin, a naturally occurring substance with cardioprotective properties, is one of the major active constituents in Radix Astragali. In this study, effect of Calycosin was investigated in vivo and in vitro to determine whether it could alleviate oxidative stress and oxidative stress‐induced cardiac apoptosis in neonatal cardiomyocytes (NCMs) via activation of aldehyde dehydrogenase 2 (ALDH2). Calycosin protected against oxidative stress and oxidative stress‐induced apoptosis in NCMs. Molecular docking revealed that the ALDH2‐Calycosin complex had a binding energy of −9.885 kcal/mol. In addition, molecular docking simulations demonstrated that the ALDH2‐Calycosin complex was stable. Using BLI assays, we confirmed that Calycosin could interact with ALDH2 (KD = 1.9 × 10−4 M). Furthermore, an ALDH2 kinase activity test revealed that Calycosin increased ALDH2 activity, exhibiting an EC50 of 91.79 μM. Pre‐incubation with ALDH2 inhibitor (CVT‐10216 or disulfiram) reduced the cardio‐protective properties Calycosin. In mice with MI, Calycosin therapy substantially reduced myocardial apoptosis, oxidative stress, and activated ALDH2. Collectively, our findings clearly suggest that Calycosin reduces oxidative stress and oxidative stress‐induced apoptosis via the regulation of ALDH2 signaling, which supports potential therapeutic use in MI.
Synergistic Effect of Sr‐O Divacancy and Exposing Facets in SrTiO3 Micro/Nano Particle: Accelerating Exciton Formation and Splitting, Highly Efficient Co2+ Photooxidation
Authors: Jia Qibo , Wang Chuyu , Liu Jian , Cai Xiaojiao , Zhong Li , Chen Siming , Li Ting , Yu Gangqiang , Wu Li‐zhu , Duan Dongping 
Published: September 2022

AbstractAs a typical perovskite‐type crystal, polyhedral strontium titanate (SrTiO3) has shown anisotropic charge transport behavior in recent studies, however, the carrier transportation and transition of which has not been explained very clearly. This work present the existence of Sr and O divacancies in the novel rhombicuboctahedron SrTiO3 micro/nano particles (Sr1−xTiO3−x/TiO2−x) with exposing (100), (110) and (111) facets and the diameter of 300–700 nm synthesized via hydrothermal synthesis, and also summarizes the dissociation mechanism of self‐trapped excitons (STEs) caused by the divacancy and facet effect. In addition, most importantly, the metastable STEs with ultra‐low binding energy (Eb < 3 meV) under illumination are discovered. Combining the model of S‐scheme heterojunction, a conversion mechanism of photoinduced carriers is proposed. The photocatalytic reaction of Co2+ is used as the probe reaction, and the unique Sr1−xTiO3−x/TiO2−x possesses a high photooxidation efficiency of Co2+, by which 70.3% of Co2+ is oxidized to Co3+ (CoOOH) in 5 min. This finding may provide a guideline for an optimal design of the photocatalytic materials for the recovery and extraction of metal ions based on SrTiO3.
Surface Passivation of Layered MoSe2 via van der Waals Stacking of Amorphous Hydrocarbon
Authors: Lee Do‐Hyeon , Dongquoc Viet , Hong Seongin , Kim Seung‐Il , Kim Eunjeong , Cho Su‐yeon , Oh Chang‐Hwan , Je Yeonjin , Kwon Mi Ji , Hoang Vo Anh , Seo Dong‐Bum , Lee Jae Hyun , Kim Sunkook , Kim Eui‐Tae , Park Jun Hong 
Published: September 2022

AbstractDevelopment of efficient surface passivation methods for semiconductor devices is crucial to counter the degradation in their electrical performance owing to scattering or trapping of carriers in the channels induced by molecular adsorption from the ambient environment. However, conventional dielectric deposition involves the formation of additional interfacial defects associated with broken covalent bonds, resulting in accidental electrostatic doping or enhanced hysteretic behavior. In this study, centimeter‐scaled van der Waals passivation of transition metal dichalcogenides (TMDCs) is demonstrated by stacking hydrocarbon (HC) dielectrics onto MoSe2 field‐effect transistors (FETs), thereby enhancing the electric performance and stability of the device, accompanied with the suppression of chemical disorder at the HC/TMDCs interface. The stacking of HC onto MoSe2 FETs enhances the carrier mobility of MoSe2 FET by over 50% at the n‐branch, and a significant decrease in hysteresis, owing to the screening of molecular adsorption. The electron mobility and hysteresis of the HC/MoSe2 FETs are verified to be nearly intact compared to those of the fabricated HC/MoSe2 FETs after exposure to ambient environment for 3 months. Consequently, the proposed design can act as a model for developing advanced nanoelectronics applications based on layered materials for mass production.
Heterostructured V‐Doped Ni2P/Ni12P5 Electrocatalysts for Hydrogen Evolution in Anion Exchange Membrane Water Electrolyzers
Authors: Zhao Tingwen , Wang Shuhao , Li Yibing , Jia Chen , Su Zhen , Hao Derek , Ni Bing‐jie , Zhang Qiang , Zhao Chuan 
Published: September 2022

AbstractRegulating the electronic structure and intrinsic activity of catalysts’ active sites with optimal hydrogen intermediates adsorption is crucial to enhancing the hydrogen evolution reaction (HER) in alkaline media. Herein, a heterostructured V‐doped Ni2P/Ni12P5 (V–Ni2P/Ni12P5) electrocatalyst is fabricated through a hydrothermal treatment and controllable phosphidation process. In comparison with pure‐phase V–Ni2P, in/ex situ characterizations and theoretical calculations reveal a redistribution of electrons and active sites in V–Ni2P/Ni12P5 due to the V doping and heterointerfaces effect. The strong coupling between Ni2P and Ni12P5 at the interface leads to an increased electron density at interfacial Ni sites while depleting at P sites, with V‐doping further promoting the electron accumulation at Ni sites. This is accompanied by the change of active sites from the anionic P sites to the interfacial Ni–V bridge sites in V–Ni2P/Ni12P5. Benefiting from the interface electronic structure, increased number of active sites, and optimized H‐adsorption energy, the V‐Ni2P/Ni12P5 exhibits an overpotential of 62 mV to deliver 10 mA cm–2 and excellent long‐term stability for HER. The V–Ni2P/Ni12P5 catalyst is applied for anion exchange membrane water electrolysis to deliver superior performance with a current density of 500 mA cm–2 at a cell voltage of 1.79 V and excellent durability.
From legacy to microservices: A type‐based approach for microservices identification using machine learning and semantic analysis
Authors: Trabelsi Imen , Abdellatif Manel , Abubaker Abdalgader , Moha Naouel , Mosser Sébastien , Ebrahimi‐Kahou Samira , Guéhéneuc Yann‐Gaël 
Published: September 2022

AbstractThe microservices architecture (MSA) style has been gaining interest in recent years because of its high scalability, ability to be deployed in the cloud, and suitability for DevOps practices. While new applications can adopt MSA from their inception, many legacy monolithic systems must be migrated to an MSA to benefit from the advantages of this architectural style. To support the migration process, we propose MicroMiner, a microservices identification approach that is based on static‐relationship analyses between code elements as well as semantic analyses of the source code. Our approach relies on machine learning (ML) techniques and uses service types to guide the identification of microservices from legacy monolithic systems. We evaluate the efficiency of our approach on four systems and compare our results to ground‐truths and to those of two state‐of‐the‐art approaches. We perform a qualitative evaluation of the resulted microservices by analyzing the business capabilities of the identified microservices. Also a quantitative analysis using the state‐of‐the‐art metrics on independence of functionality and modularity of services was conducted. Our results show the effectiveness of our approach to automate one of the most time‐consuming steps in the migration of legacy systems to microservices. The proposed approach identifies architecturally significant microservices with a 68.15% precision and 77% recall.
Elemgasem nubilus: a new brachyrostran abelisaurid (Theropoda, Ceratosauria) from the Portezuelo Formation (Upper Cretaceous) of Patagonia, Argentina
Authors: Baiano Mattia A. , Pol Diego , Bellardini Flavio , Windholz Guillermo J. , Cerda Ignacio A. , Garrido Alberto C. , Coria Rodolfo A. 
Published: September 2022

AbstractAbelisaurids are medium–large‐sized theropod dinosaurs that were predominant in the carnivorous fauna during the Late Cretaceous of Gondwana. These predators are abundant in the Cretaceous fossil strata of Patagonia, which yield the best record for this group. In the Late Cretaceous, abelisaurids appear in almost all regions of Gondwana and in all stages, except for the Coniacian, in which they are globally unknown. Here we describe a new abelisaurid,Elemgasem nubilusgen. et sp. nov., from the Portezuelo Formation (Turonian–Coniacian), Patagonia, Argentina. The palaeohistology of the appendicular bones ofElemgasemshows that the holotype was a subadult individual, but had achieved sexual maturity. This taxon is based on several axial and appendicular elements, and is diagnosed by the presence of a marked pattern of rugosity on the lateral surface of the fibula and a dorsoventrally deep lateral wall of the calcaneum. Moreover, the posterior caudal vertebrae have a morphology slightly different from any other abelisaurid.Elemgasem nubilusis recovered as an unstable taxon within Brachyrostra, given that it was recovered as sister taxon of Furileusauria or in several positions within this clade. Despite the problematic phylogenetic relationships ofElemgasem nubilus, it is important because it is the first abelisaurid from the Turonian–Coniacian interval and it increases the diversity of this theropod family at a time of marked turnover in the tetrapod fauna of South America, global climate change, and mass extinction events recorded worldwide in the marine realm.
China's outward foreign direct investment in Southeast Asia: Analyzing the Chinese state's strategies and potential influence
Authors: Chiang Min‐Hua , de Micheaux Elsa Lafaye 
Published: September 2022

AbstractThrough a comparative study of China's global and regional outward foreign direct investment (OFDI), this article seeks to understand the Chinese state's motives behind such investment, and how it leverages its OFDI to influence the regional economy in the Association of Southeast Asian Nations (ASEAN). The analysis reveals several findings. First, the status of ASEAN states in China's global OFDI project have changed in the last decade from destinations for infrastructure investment to essential manufacturing hubs. The launch of the Belt and Road Initiative (BRI) did, in part, allow for this shift, insofar as it diversified the financial channels that facilitate the region's infrastructure development, thereby enabling China to concentrate its OFDI on manufacturing and service linkages throughout the region. Second, whereas China originally directed the majority of its OFDI to low‐income ASEAN countries, after 2013, it began to direct greater levels of OFDI to middle and high‐income ASEAN countries. This shift did not necessarily grant China greater influence in those countries owing to the much more inward FDI from other developed economies, while China has continued to leverage its OFDI in low‐income ASEAN countries to great effect. Third, China might enjoy greater influence in the infrastructure and manufacturing sectors in the region given its greater investment in these two sectors, as compared to that of other developed countries. China's influence in the regional service industry, meanwhile, continues to be less noteworthy, comparatively.
Associations between polymorphisms of LAP3 and SIRT1 genes with clinical mastitis and milk production traits in Sahiwal and Karan Fries dairy cattle
Authors: Worku Destaw , Gowane G. R. , Mukherjee Anupama , Alex Rani , Joshi Pooja , Verma Archana 
Published: September 2022

AbstractBackgroundBovine mastitis continues to remain as the most challenging disease in dairy cattle, as a result improvement of selection methods has great economic relevance while a deeper understanding of the genetic mechanisms regulating milk production traits and mastitis is of general scientific interest.ObjectivesThis study aimed to evaluate the association of SNPs of the LAP3 and SIRT1 genes with estimated breeding values (EBVs) of milk production traits and clinical mastitis in dairy cattle of Indian origin.MethodsDNA samples from 263 animals (Sahiwal and Karan Fries cattle) were genotyped by PCR‐RFLP to assess their pattern of genetic variation. EBVs of milk production traits and phenotypic records of incidences of clinical mastitis were used for association analysis.ResultsA total of 9 SNPs were identified, including three (rs110932626: A>G, rs716493845: C>T and rs43702363: C>T) in intron 12, four (g.24904G>C, rs110839532: G>T, rs43702361: T>C and rs41255599: C>T) in exon 13 and within 3’UTR of LAP3 gene and two (rs110250233: G>A and rs42140046: C>G) in the promoter region of SIRT1 gene. Eight of these identified SNPs were chosen for subsequent genotyping and association analyses. Association analysis revealed that SNP rs41255599: C>T was significantly associated with lactation milk yield, 305‐day milk yield, 305‐day fat yield, 305‐day solid not fat yield, lactation length and incidence of clinical mastitis (p < 0.05) in Sahiwal cattle. For Karan Fries cattle, two SNPs including rs110932626: A>G and rs43702363: C>T showed significant association with 305‐day milk yield.ConclusionOverall, these findings provide evidence for association of the LAP3 gene with milk production traits and clinical mastitis in dairy cattle, indicating the potential role of LAP3 variants in these traits.
Suspected lidocaine toxicity and the use of metoclopramide and neostigmine to treat post‐operative small intestinal ileus in a donkey
Authors: Wood Francesca , Loomes Kate 
Published: September 2022

AbstractA 17‐year‐old donkey underwent exploratory laparotomy to correct a caecal impaction via typhlotomy in combination with pelvic flexure enterotomy. Intravenous lidocaine (3 mg/kg/h; lidocaine 2% solution, BOVA Specials, London, UK) was administered throughout general anaesthesia following a loading dose (1.3 mg/kg, intravenously [IV]). The donkey recovered uneventfully. One hour after recovery, shortly after returning to the stable and commencement of lidocaine, the donkey showed ataxia, muscle fasciculations and tachycardia with progression to recumbency. Lidocaine toxicity was presumed, so the infusion was stopped and the donkey returned to standing. On Day 2 after surgery, post‐operative reflux was voluminous, so a metoclopramide infusion (0.04 mg/kg/h IV; metoclopramide 5 mg/ml injection, Siegfried Hameln, Hameln, Germany) was commenced. On Day 3, post‐operative reflux persisted, so a neostigmine infusion (0.008 mg/kg/h IV; neostigmine methylsulfate injection 2.5 mg/ml, Siegfried Hameln, Hameln, Germany) was also administered. Small intestinal motility improved by Day 5 and post‐operative reflux resolved by Day 6. Both infusions were stopped and food was re‐introduced. There was no further indication of gastrointestinal hypomotility and the donkey was discharged 11 days later.
Non‐coding RNAs in diseases with a focus on osteoarthritis
Authors: Pekáčová Aneta , Baloun Jiří , Švec Xiao , Šenolt Ladislav 
Published: September 2022

AbstractOsteoarthritis (OA) is a frequent musculoskeletal disorder affecting millions of people worldwide. Despite advances in understanding the pathogenesis of OA, prognostic biomarkers or effective targeted treatment are not currently available. Research on epigenetic factors has yielded some new insights as new technologies for their detection continue to emerge. In this context, non‐coding RNAs, including microRNAs, long non‐coding RNAs, circular RNAs, piwi‐interacting RNAs, and small nucleolar RNAs, regulate intracellular signaling pathways and biological processes that have a crucial role in the development of several diseases. In this review, we present current knowledge on the role of epigenetic factors with a focus on non‐coding RNAs in the development, prediction and treatment of OA.This article is categorized under:
RNA in Disease and Development > RNA in Disease
Catenated (Bi)n(n=2, 3, 4) Complexes with Formally Monovalent Bismuth Centres
Authors: Schwamm Ryan J. , Kilpatrick Alexander F. R. , Coles Martyn P. 
Published: September 2022

AbstractThe reduction of Bi(III) and Bi(II) compounds supported by the NONR‐ligand (NONR=[O(SiMe2NR)2]2−; R=Dipp=2,6‐iPr2C6H3,tBu) afforded species in which the metal was present in a range of formal oxidation‐states. Cyclic voltammetry performed on the Bi(II) radical [Bi(NONDipp)]⋅ indicated that the Bi(I) oxidation state was accessible, although the lifetime of the resultant species was short. Preparative scale reactions of Bi(NONDipp)Cl and excess LiBEt3H afforded the tetrametallic cluster Bi4(NONDipp)2, in which the bismuth atoms form a [1,2]‐edge missing tetrahedron. Reduction of the dibismuthane [Bi(NONtBu)]2with potassium in the presence of [2.2.2]‐cryptand generated a tribismuthinide salt containing the [{Bi(NONtBu)}2(μ‐Bi)]−anion and a non‐coordinating [K([2.2.2]‐crypt)]+cation. Reduction of isolated [Bi(NONDipp)]⋅ with the Mg(I) reagent [Mg(BDIDipp)]2(BDIDipp=[HC{C(Me)NDipp}2]−) formed the dibismuthene [Bi(μ‐NONDipp)Mg(BDIDipp)(THF)]2, with a crystallographically verified Bi=Bi multiple bond.
Vote Versus Veto
Authors: Duff Andrew 
Published: September 2022

AbstractAt the heart of the case for a federal Europe is the need to extend qualified majority voting (QMV) in the Council and co-decision with the European Parliament. Legislative procedures need simplification and clarification. All special laws of the Council should be replaced by introducing a formal class of organic law. Constraints on the use of the passerelle clauses should be eased, along with the relaxation of the provisions on enhanced cooperation to encourage the emergence of a vanguard. The procedures for future treaty revision should be liberalised, bringing them into line with other federal and international organisations.
Immigrant Work Integration: A Wicked Problem
Authors: Nardon Luciara , Hari Amrita 
Published: September 2022

AbstractThis introductory chapter discusses qualified immigrants’ (QIs) work integration as a wicked problem, highlighting their underemployment or unemployment despite receiving countries’ reported labor shortages and need for talent. We outline the goals of this book and establish sensemaking as an emerging yet underdeveloped theoretical approach to studying this wicked problem. We begin with some key definitions, provide specific examples from Canada (the primary site of our ongoing fieldwork), and sketch the structure of this book.