bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracing the Development of the Proportionality Analysis in Relation to Forced Evictions under the ICESCR
Authors: Grohmann Nils-Hendrik 
Published: August 2022

Abstract
Since 2013, the Committee on Economic, Social and Cultural Rights can examine individual communications under the Optional Protocol to the International Covenant on Economic, Social and Cultural Rights (ICESCR). This opens up the possibility to interpret Covenant provisions in a thorough manner. With regard to forced evictions and the right to housing under Article 11 ICESCR, one can discern a fast-developing approach concerning the proportionality analysis of evictions, entailing the establishment of specific criteria that may guide such analysis. This paper seeks to delineate these developments and will also shed light on possible general trends on the topic of limitations within the Committee’s emerging jurisprudence. In doing so, the paper will address if, and how, the developing proportionality analysis under the individual complaints procedure takes into consideration multi-discriminatory dimensions of State measures and how it specifically relates to or incorporates other ICESCR-concepts, such as minimum core obligations or the reasonableness review under Article 8(4) OP ICESCR.
Postvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD
Authors: Li Dalin , Debbas Philip , Mujukian Angela , Cheng Susan , Braun Jonathan , McGovern Dermot P B , Melmed Gil Y ,   CORALE-IBD Study Group, Banty Andrea , Feldman Edward , Ha Christina , Lee Susie , Rabizadeh Shervin , Stein Theodore , Solomon Theodore , Syal Gaurav , Targan Stephan , Vasiliauskas Eric , Ziring David , Bonthala Niru , Botwin Gregory S , Hampton Melissa , Mengesha Emebet , Khanishian Elizabeth , Pozdnyakova Valeriya , Gu Phillip , White Shane , Zamudio Cindy , Gonzalez Daniel , Parry Alyssa , Hanna Mary , Chan Justin , Ebinger Joe , Joung Sandy , Wu Min , Hoang Amy , Wynter Timothy , Sun Nancy , Figueiredo Jane C , Merchant Akil , Merin Noah , Reckamp Karen L , Appel Keren , Kumar Rashmi , Boland Brigid , Charabaty Aline , Chiorean Michael , Cohen Erica , Flynn Ann , Valentine John , Ehrlich Adam C , Fudman David , Horizon Arash , Karayev Dmitry , Kretzmann Benjamin , Hou Jason , Hwang Caroline , Lazarev Mark , Lum Donald , Fausel Rebecca , Reddy Swapna , McConnell Ryan , Mattar Mark C , Metwally Mark , Ostrov Arthur , Parekh Nimisha , Raffals Laura , Rubin David T , Sheibani Sarah , Siegel Corey A , Wolf Douglas , Younes Ziad , Damas Oriana 
Published: August 2022

AbstractBackgroundThe safety of a third dose of SARS-CoV-2 mRNA vaccination in patients with inflammatory bowel disease is unknown.MethodsWe compared symptoms following a third SARS-CoV-2 mRNA vaccine dose with symptoms after the second dose in IBD.ResultsThe study group included 594 patients (70% female, 58% BNT162b2). Overall, 41% reported symptoms after a third dose. Symptom frequency and severity were lower after the third dose relative to the second dose for every organ system, except for gastrointestinal symptoms which were marginally worse.ConclusionThe frequency and severity of symptoms after a third mRNA vaccine dose are generally similar or milder than after a second dose for most organ systems.
Porcelain aorta does not mean inoperability but needs special strategies
Authors: Carrel Thierry , Vogt Paul Robert 
Published: August 2022

Abstract
Porcelain aorta is not an absolute contraindication for aortic valve and/or coronary bypass grafting but it requires a special strategy and individualized approach to minimize the risk of embolic complications and technical problems during opening and/or closing the aortotomy.
Radiological unilateral pleuroparenchymal fibroelastosis as a notable late complication after lung cancer surgery: incidence and perioperative associated factors
Authors: Inafuku Kenji , Sekine Akimasa , Arai Hiromasa , Hagiwara Eri , Komatsu Shigeru , Iwasawa Tae , Misumi Toshihiro , Kikunishi Noritake , Tajiri Michihiko , Okudela Koji , Rino Yasushi , Ogura Takashi 
Published: August 2022

Abstract

OBJECTIVES
Pleuroparenchymal fibroelastosis (PPFE) is a rare idiopathic interstitial pneumonia characterized by pleural-parenchymal involvement, predominantly in the upper lobes. Unilateral upper lung field pulmonary fibrosis (upper-PF) that is radiologically consistent with PPFE reportedly develops after lung cancer surgery in the operated side and presents many clinical characteristics in common with PPFE. However, the incidence and perioperative associated factors remain unclear.

METHODS
All consecutive patients with lung cancer resected completely from 2008 to 2016 were investigated retrospectively. Pre-/postoperative characteristics were compared between patients with and without unilateral upper-PF. Cumulative incidence curves were estimated using competing risk analysis.

RESULTS
Among the 587 included patients, 25 patients (4.3%) were diagnosed as unilateral upper-PF. The 3-, 5- and 10-year cumulative incidence of unilateral upper-PF was 2.3%, 3.3% and 5.3%, respectively. In multivariable analysis, male sex, presence of a pulmonary apical cap, lobar resection and low % vital capacity (%VC &lt; 80%) were independent perioperative associated factors. The 10-year cumulative incidence was 6.3% in patients treated with lobar resection, 8.0% in male patients, 10.3% in patients with pulmonary apical cap and 14.5% in patients with low %VC. Postoperative pleural effusion at 6 months after surgery was much more common in the patients who later developed unilateral upper-PF (96.0% vs 24.2%). This pleural effusion persisted and was accompanied thereafter by pleural thickening and subpleural pulmonary fibrosis. During the clinical courses of 25 patients with unilateral upper-PF, 18 patients presented symptoms related to upper-PF and 6 patients died.

CONCLUSIONS
Unilateral upper-PF is an occasional but under-recognized late complication after lung cancer surgery.
A Participant-Level Integrative Data Analysis of Differential Placebo Response for Suicidal Ideation and Nonsuicidal Depressive Symptoms in Clinical Trials of Intravenous Racemic Ketamine
Authors: Bloomfield-Clagett Bartholt , Ballard Elizabeth D , Greenstein Deanna K , Wilkinson Samuel T , Grunebaum Michael F , Murrough James W , Mathew Sanjay J , Phillips Jennifer L , Fava Maurizio , Sanacora Gerard , Zarate Carlos A 
Published: August 2022

Abstract

Background
Clinical trials of intravenous (IV) racemic (R,S)-ketamine (hereafter referred to as IV ketamine) have consistently reported rapid and substantial reductions in overall depressive symptoms compared with saline (inactive placebo) or midazolam (active placebo). The evidence for IV ketamine’s specific effects on suicidal ideation is less clear, however. This study sought to examine whether differential placebo (saline or midazolam) response to overall depressive symptoms vs suicidal ideation may help explain these divergent findings.

Methods
Data for this participant-level integrative data analysis were drawn from 151 participants across 10 studies, and linear regression was used to examine the relationship between placebo response for suicidal ideation vs other depressive symptoms indexed from standard rating scales—specifically, depressed mood, anhedonia, anxiety, and guilt—over time.

Results
For participants receiving saline placebo (n = 46), greater placebo response was observed for suicidal ideation compared with other symptoms indexed from standard depression rating scales, except for anxiety. For those receiving midazolam placebo (n = 105), greater placebo response was observed for suicidal ideation compared with depressed mood or anhedonia, and no significant differences were observed when comparing suicidal ideation with anxiety or guilt.

Conclusions
Taken together, the results provide preliminary evidence of a differential placebo response for suicidal ideation vs other depressive symptoms, while anxiety and suicidal ideation appear to produce similar placebo response profiles. These findings may help explain the more modest findings in clinical IV ketamine trials for suicidal ideation than overall depression.
CCR4 plays a pivotal role in Th17 cell recruitment and expansion in a mouse model of rheumatoid arthritis
Authors: Honzawa Tatsuma , Matsuo Kazuhiko , Hosokawa Shunya , Kamimura Mayu , Kaibori Yuichiro , Hara Yuta , Nagakubo Daisuke , Oiso Naoki , Kawada Akira , Otsuka Atsushi , Yoshie Osamu , Nakayama Takashi 
Published: August 2022

Abstract
T helper 17 (Th17) cells express CC chemokine receptor 4 (CCR4) and secrete cytokines such as interleukin-17A (IL-17A) and granulocyte macrophage colony-stimulating factor (GM-CSF), while dendritic cells (DCs) produce CC chemokine ligand 22 (CCL22), a CCR4 ligand, upon stimulation with GM-CSF. Th17 cells are known to play a critical role in the pathogenesis of rheumatoid arthritis (RA). CCL22 has also been shown to be up-regulated in the synovial tissues of RA patients. Here, we investigated the role of CCR4 in collagen-induced arthritis (CIA), a mouse model of RA. DBA/1J mice efficiently developed CIA as shown by erythema, paw swelling, joint rigidity, and joint destruction. Th17 cells were increased in the arthritic joints and regional lymph nodes (LNs) of CIA mice. A fraction of Th17 cells were also shown to produce GM-CSF. On the other hand, we observed no significant increases of Th2 cells or Treg cells, the T cell subsets also known to express CCR4, in these tissues. We further observed clusters of CCR4-expressing memory Th17 cells and CCL22-producing DCs in the regional LNs of CIA mice, supporting the role of the CCR4-CCL22 axis in the expansion of Th17 cells in the regional LNs. Compound 22, a CCR4 inhibitor, ameliorated the disease severity with reduction of Th17 cells in the arthritic joints and regional LNs and Th17-DC clusters in the regional LNs. We further confirmed that CCR4-deficient mice in the C57BL/6J background were highly resistant to CIA induction compared with wild-type mice. Collectively, CCR4 contributes to the pathogenesis of CIA and may thus represent a new therapeutic target for RA.
Clinical and microbiological evaluation of temocillin for bloodstream infections with Enterobacterales: a Belgian single-centre retrospective study
Authors: Oosterbos Julie , Schalkwijk Maaike , Thiessen Steven , Oris Els , Coppens Guy , Lagrou Katrien , Steensels Deborah 
Published: August 2022

Abstract

Background
Expanding the use of temocillin could be an important weapon in the fight against antimicrobial resistance. However, EUCAST defined clinical breakpoints for a limited number of species and only for urinary tract infections (UTI), including urosepsis but excluding severe sepsis and septic shock. Moreover, a dosage of 2 g q8h is advised in most cases.

Objectives
Evaluation of temocillin use for the treatment of bacteraemia, correlating clinical and microbiological outcomes with infection site, infection severity, temocillin dosage, Enterobacterales species and MIC.

Patients and methods
All adult patients with blood cultures positive for temocillin-susceptible Enterobacterales and treated with temocillin for ≥72 h from June 2018 until June 2021 were considered for inclusion. The primary outcome was clinical success, defined as resolution of infection signs, no relapse of the same infection and no antibiotic switch due to insufficient clinical improvement. The secondary outcome was microbiological success.

Results
In total, 182 episodes were included [140 UTI versus 42 non-UTI, 171 Escherichia coli, Klebsiella species (except Klebsiella aerogenes) and Proteus mirabilis (EKPs) versus 11 non-EKPs]. Clinical and microbiological failure were low (8% and 3%, respectively). No difference in outcome was observed for dosages of 2 g q12h versus 2 g q8h, either for EKP versus non-EKP isolates or MIC values ≤8 versus 16 mg/L. Considering only bacteraemia episodes of UTI origin, using the 16 mg/L breakpoint, there was no difference in success rate between regimens of 2 g q12h and 2 g q8h.

Conclusions
Temocillin 2 g q12h can be successfully used for the treatment of systemic UTI. Prospective studies are needed to assess outcomes and evaluate non-inferiority compared with other broad-spectrum antibiotics in non-UTI infections, including bacteraemia.
Statistical Capacity Matters: The Long-Term Effects of Africa’s Slave Trade on Development Reflected by Nighttime Light Intensity
Authors: Gören Erkan , Winkler Adalbert 
Published: August 2022

Abstract
Empirical research depends on reliable data. Yet, in many countries, statistical agencies do not have the capacity to collect high-quality data on economic development. This is especially the case in Africa, where the capacity to collect such data is affected by the same historical factors that explain economic development—in particular, the slave trade. We hypothesise that the impact of the slave trade on economic development in Africa is biased because cross-country heterogeneity in statistical capacity related to the slave trade creates a non-classical measurement error in gross domestic product (GDP) per capita. Our empirical evidence supports this view. When replacing GDP per capita by nighttime light intensity per capita—an indicator of economic development unrelated to statistical capacity—the impact of the slave trade on economic development drops by a factor of 2–4 depending on model specification and estimation methodology (OLS, IV and high-dimensional sparse models). Various robustness tests further corroborate our main hypothesis.
The effects of supplementation of noni (Morinda citrifolia L.) fruit polysaccharides-rich extract on antioxidant status and immune function in cashmere goats
Authors: Zhang Qingyue , Li Yinhao , Yin Guolin , Li Yuan , Zhao Yanli , Guo Xiaoyu , Guo Yongmei , Yan Sumei 
Published: August 2022

Abstract
This experiment was designed to examine the effects of a dietary supplementation of polysaccharides-rich noni (Morinda citrifolia L.) fruit extract (NFP) on the anti-oxidant enzyme activities, cytokines level, and expression of corresponding genes in blood of cashmere goats. Twelve castrated, 2-yr-old male cashmere goats (45.44 ± 3.30 kg of BW ± SD) were used in a 2 × 2 crossover design: the basal diet with or without (CON) supplementation of NFP at 4 g per kg DM (0.4%). Each period lasted for 29 d, including 1 wk for diet transition, 20 d for adaptation, and the last 2 d for sampling. The results showed that NFP supplementation increased (P &lt; 0.05) the levels of nitric oxide, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), and the activities of catalase (CAT), glutathione peroxidase (GPx), thioredoxin reductase (TrxR), and total superoxide dismutase (T-SOD) in serum. The expressions of CAT, GPx4, TrxR, SOD1, IL-6, and TNF-α genes were upregulated (P &lt; 0.05), whereas the levels of malondialdehyde (P = 0.015) and reactive oxygen species (P = 0.051) in serum were reduced. The body weight gain of goats was increased (P = 0.006) with a nonsignificant increase of feed intake with NFP supplementation. In conclusion, dietary NFP supplementation enhanced the antioxidant status and immune function in blood of cashmere goats.
The Ambrosia BeetleMegaplatypus mutatus: A Threat to Global Broad-Leaved Forest Resources
Authors: Ceriani-Nakamurakare Esteban , Robles Carolina , González-Audino Paola , Dolinko Andrés , Mc Cargo Patricia , Corley Juan , Allison Jeremy , Carmarán Cecilia 
Published: August 2022

AbstractWe provide scientists and decision-makers with up-to-date information on Megaplatypus mutatus (Coleoptera: Curculionidae: Platypodinae), a forest insect native to South America that has invaded other regions. Emphasis is given to information that may prove relevant for the development of early detection, containment and management programs and improved risk analyses. The increase in global movement of people and goods, coupled with expected climatic scenarios, suggests that M. mutatus may arrive and establish populations in new areas. The major impact of this forest pest has always been reported in exotic tree species, even within its native range. The absence of a coevolutionary history with ‘naïve’ host trees is a relevant factor when analyzing and understanding the magnitude of the problem posed by this beetle and fungi associated with it. Notably, among preferred hosts are the widely planted Eucalyptus and Populus spp., facilitating the invasion of this insect into new regions and posing a threat to commercial forestry.
Muslim saints contested: Ibn Taymiyya’s critique of al-Qushayrī’s Risāla
Authors: Gasimov Kamal 
Published: August 2022

Abstract
This article analyses Ibn Taymiyya’s neglected commentary on ʿAbū al-Qāsim al-Qushayrī ’s Epistle on Sufism (al-Risāla al-Qushayriyya fī ʿilm al-taṣawwuf), in which he wages several intellectual battles simultaneously: with Ashʿarī theologians of earlier centuries, such as al-Qushayrī himself; with his Ashʿarī contemporaries like Ibn Jahbal al-Kilābī; and with advocates in Damascus and Cairo of Ibn al-ʿArabī’s monistic teachings. Ibn Taymiyya deploys a set of historical and discursive arguments rooted in the early Sufi historiography to argue that both Ashaʿrīs and monistic-minded Sufis do not have a rightful claim to the heritage of the early Sufi authorities. In the struggle to define ‘Islamic orthodoxy’, Ashaʿrīs and Ḥanbalīs evince two radically different approaches to Sufi sayings. Al-Qushayrī and Ibn Jahbal affirm the harmony between Sufi utterances and the rational proofs of speculative theology (kalām), while, in stark contrast, Ibn Taymiyya accentuates their ascetic-mystical connotations. This Ḥanbalī–Ashʿarī debate comprised two conflicting attitudes to the notion of ‘Muslim sainthood’ (wilāya): the Ashʿarīs insisted that early Sufi saintly figures (awliyāʾ) mastered the principles of kalām in order to explain the nature of God to different classes of the Muslim community, while Ibn Taymiyya believed that this type of theological reasoning undermined the very foundations of the spiritual teachings of the early Sufis and retarded the spiritual growth of those who undertook the Sufi path. These polemical exchanges demonstrate that Sufi figures, concepts, images, and texts became central to the articulation of theological arguments during the early Mamluk sultanate.
Anti-tumor effects of Thymus Caramanicus Jalas extract in mice through oxidative stress, inflammation and apoptosis
Authors: Hassanshahi Jalal , Hajializadeh Zahra , Niknia Seddigheh , Mahmoodi Mehdi , Kaeidi Ayat 
Published: August 2022

Abstract

Objective
Breast cancer causes death in women. Thymus Caramanicus Jalas (TCJ) as a polyphenolic plant has an antiproliferative effect. Accordingly, this investigation studied the TCJ extract anti-tumor effects in a breast cancer model.

Methods
Twenty-four female BALB/c mice were used in 4 groups including (1) breast cancer (control); (2), (3) and (4) breast cancer + 100, 300 and 500 mg/kg of TCJ extract (once daily for 20-days after breast tumor induction). The breast tumour was induced by 4T1 cell carcinoma injection. Then tumor size and weight were measured. Tumor necrosis factor-α (TNF-α), nuclear factor κ-B (NF-κB), interleukin-6 (IL-6) as inflammatory markers and also Bcl-2, Bax, cytosolic cytochrome-c, apoptosis-inducing factor, and cleaved caspase-3 as biochemical apoptosis markers were evaluated in tumor tissue with western blotting analysis. Also, malondialdehyde (MDA) concentration, hydrogen peroxidase (H2O2), catalase, glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were exanimated.

Key findings
Treatment with TCJ extract (500 mg/kg) decreased the tumor volume, tumor weight, GPx, SOD, and catalase enzyme activity versus the control group (P &lt; 0.05). Also, TCJ (500 mg/kg) extract increased MDA, H2O2, inflammatory and apoptosis markers versus control (P &lt; 0.05).

Conclusions
Current study showed that TCJ can induce anti-tumour effects via promoting inflammation, apoptosis, and oxidative stress in breast tumour tissue.
Characterization of the PHOSPHATE RESPONSE 2-dependent and -independent Pi-starvation response secretome in rice
Authors: Du Zezhen , Deng Suren , Wu Zixuan , Cai Hongmei , Xu Fangsen , Shi Lei , Wang Sheliang , Ding Guangda , Wang Chuang 
Published: August 2022

Abstract
Many proteins secreted from plant cells into the surrounding extracellular space help maintain cell structure and regulate stress responses in the external environment. In this study, under Pi-replete and depleted conditions, 652 high-confidence secreted proteins were quantified from wild-type (WT) and PHOSPHATE RESPONSE 2 (OsPHR2)-overexpressing suspension-cultured cells (SCCs). These proteins were functionally grouped as phosphatases, signal transduction proteins, pathogen-related (PR) proteins, cell wall-remodeling proteins, and reactive oxygen species (ROS) metabolism proteins. Although PHOSPHATE RESPONSE (PHR) transcription factors regulate two-thirds of Pi-responsive genes at the transcriptional level, only 30.6% of the Pi-starvation-regulated secreted proteins showed significant changes in OsPHR2-overexpressing SCCs. The OsPHR2-dependent systemic Pi signaling pathway mainly regulates phosphatases and PR proteins, which are involved in the utilization of organophosphate, pathogen resistance, and colonization by rhizosphere microorganisms. The OsPHR2-independent local Pi signaling pathway, on the other hand, largely regulated ROS metabolism proteins, cell wall-remodeling proteins, and signal transduction proteins, which are involved in modifying cell wall structure and root architecture. The functions of differentially expressed secreted proteins between WT and OsPHR2-overexpressing plants under Pi-sufficient and Pi-deficient conditions were further confirmed by analysis of the acid phosphatase activity, ROS content, and cell wall composition.
ASAS-SN follow-up of IceCube high-energy neutrino alerts
Authors: Necker Jannis , de Jaeger Thomas , Stein Robert , Franckowiak Anna , Shappee Benjamin J , Kowalski Marek , Kochanek Christopher S , Stanek Krzysztof Z , Beacom John F , Desai Dhvanil D , Neumann Kyle , Jayasinghe Tharindu , Holoien T W-S , Thompson Todd A , Holmbo Simon 
Published: August 2022

ABSTRACT
We report on the search for optical counterparts to IceCube neutrino alerts released between 2016 April and 2021 August with the All-Sky Automated Survey for SuperNovae (ASAS-SN). Despite the discovery of a diffuse astrophysical high-energy neutrino flux in 2013, the source of those neutrinos remains largely unknown. Since 2016, IceCube has published likely astrophysical neutrinos as public real-time alerts. Through a combination of normal survey and triggered target-of-opportunity observations, ASAS-SN obtained images within 1 h of the neutrino detection for 20 per cent (11) of all observable IceCube alerts and within one day for another 57 per cent (32). For all observable alerts, we obtained images within at least two weeks from the neutrino alert. ASAS-SN provides the only optical follow-up for about 17 per cent of IceCube’s neutrino alerts. We recover the two previously claimed counterparts to neutrino alerts, the flaring-blazar TXS 0506 + 056 and the tidal disruption event AT2019dsg. We investigate the light curves of previously detected transients in the alert footprints, but do not identify any further candidate neutrino sources. We also analysed the optical light curves of Fermi 4FGL sources coincident with high-energy neutrino alerts, but do not identify any contemporaneous flaring activity. Finally, we derive constraints on the luminosity functions of neutrino sources for a range of assumed evolution models.