bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental investigations on water absorption and mechanical properties of expanded perlite mortar under accelerated and natural aging conditions
Authors: Ye Jin , Yuan Kelong , Xiong Houren , Bin Sha  , Wei Tingting , Wu Lihua , Gao Dong , Chen Jianwei 
Published: June 2022

Abstract
The objective of this paper is to study the variation in the physical and mechanical properties of expanded perlite mortar with environmental factors and analyze its deterioration mechanism. In this paper, the influence of the heat-rain cyclic and natural aging on the physical and mechanical properties of expanded perlite mortar has been studied. The expanded perlite mortar specimens were subjected to 80 heat-rain cycles (the maximum temperature rises to 70 °C, and the spray volume reaches 1 l/(m2 min)) and 60-day natural aging tests (the daily average temperature is 23 °C, with the maximum temperature reaching 36 °C). The corresponding mass loss rate, water absorption, and compressive strength of the specimens at every 10 heat-rain cycles and 10 days were determined. The results show that the mass loss rate gradually increases with the increase in heat-rain cycles and the natural aging days. The variation range was found as about 0.2%∼0.7% and −0.4%∼0.2%, respectively. The water absorption rate gradually decreases with the number of heat-rain cycles and natural aging days; however, the decay rate of the water absorption rate differs by orders of magnitude in the two weathering conditions. The compressive strength does not have an obvious change with the number of heat rain cycles, but it first increases and then decreases with the number of natural aging days. Under artificial and natural aging, the deterioration mechanism and aging speed of expanded perlite mortar are much different. The comparative analysis of the physical and mechanical properties of expanded perlite mortar under artificially accelerated and natural aging conditions can further reveal its evolution model and the corresponding relationships under the two conditions and provide a theoretical basis for establishing a more scientific and reasonable aging system.
Correlation of 24-Hour Urinary Microalbumin and Atrial Arrhythmia in Patients With Essential Hypertension
Authors: Naderemu Paermanjiang , Zhang Jun-shi , Liu Hai-ming , Xu Xin-juan 
Published: June 2022

Abstract

Background
To investigate the relationship between 24-hour urinary microalbumin (24h-UmAlb) and atrial arrhythmia in patients with essential hypertension (EH).

Methods
From March 2018 to January 2020, 917 EH patients at First Affiliated Hospital of Xinjiang Medical University were enrolled, and divided into nonatrial arrhythmia and atrial arrhythmia groups according to their 24-hour dynamic electrocardiography. The general clinical data and laboratory test parameters were compared.

Results
Compared with patients without atrial arrhythmia, the 24-UmAlb level was higher in patients with atrial arrhythmia (8.0, 5.0–19.7 vs. 7.5, 4.5–15.5 mg/24 hours, Z = −2.190, P &lt; 0.05). Multivariate regression analysis showed that positive 24-UmAlb (odds ratio = 1.649, 95% confidence interval 1.065–2.554) and supine angiotensin II (odds ratio = 1.407, 95% confidence interval 1.034–1.914) were the risk factor for atrial arrhythmia in patients with EH after adjusted for left atrial diameter, age, course of hypertension, 24-hour systolic and diastolic blood pressure.

Conclusions
24h-UmAlb is one of the risk factors for atrial arrhythmia in patients with EH.
How Can Research and Theory Enhance Understanding of Professional Decision-Making in Reviews of Cases of Child Death and Serious Injury?
Authors: Gillingham Philip , Whittaker Andrew 
Published: June 2022

Abstract
In most child protection jurisdictions, a case of child death or serious injury through the actions or inaction of a parent or carer is responded to with an inquiry into the circumstances that led to the death of the child. A key objective of such inquiries is to discern what may have been done by public agencies to prevent the child’s death or serious injury and this may, in turn, lead to changes in existing policies or the development of new policies. Such changes have, at times, been criticised as ‘knee jerk’ reactions and can lead to well-meaning but possibly counter-productive initiatives. A general observation is that, in some inquiry reports, there is little, if any, reference to research and theory about child protection practice and policy. In this article, an anonymised case study of a child death inquiry is used to analyse the decision-making processes of child protection practitioners using a range of theory and research. The aim is to demonstrate how the use of insights from theory and research can lead to an enhanced understanding of the circumstances that led to a child death or serious injury, one which is grounded in current knowledge and evidence.
Indicators of Suboptimal Treatment and Associated Healthcare Costs Among Patients With Crohn’s Disease Initiated on Biologic or Conventional Agents
Authors: Pilon Dominic , Ding Zhijie , Muser Erik , Manceur Ameur M , Vermette-Laforme Maude , Lafeuille Marie-Hélène , Lefebvre Patrick 
Published: June 2022

Abstract

Background
As the treatment landscape for Crohn’s disease (CD) evolves, an up-to-date understanding of the burden associated with indicators of suboptimal treatment is needed. The aim of this study was to describe suboptimal treatment indicators and associated healthcare costs among CD patients initiated on a biologic or conventional agent.

Methods
Adults with CD were identified in a US healthcare claims database (Optum’s Clinformatics Data Mart; 01/2004–03/2019). The first biologic or conventional agent claim within 12 months of a CD diagnosis was the index date/agent. Indicators of suboptimal treatment (nonadherence, dose escalation, chronic corticosteroid use, augmentation, ≥1 CD surgery, ≥2 CD emergency department visits, ≥1 CD inpatient (IP) stay, switch, cycling, restart, inadequate induction) were identified in the 12-month postindex landmark period. The mean per-patient-per-year (PPPY) healthcare costs (2019 USD) were evaluated in the year postlandmark.

Results
There were 5107 patients (mean age ~44 years, 56% female) in the biologic and 6072 patients (~51 years; 59% female) in the conventional cohort. In the biologic cohort, 79.4% of patients had ≥1 suboptimal treatment indicator. Mean PPPY healthcare costs increased with the number of suboptimal treatment indicators, from $46 100 (no indicator) to $68 572 (≥4 indicators). The conventional cohort had similar patterns: 72.5% of patients presented ≥1 suboptimal treatment indicator, and mean PPPY healthcare costs increased from $17 329 (no indicator) to $67 568 (≥4 indicators). In both cohorts, IP and outpatient medical costs (excluding biologics) contributed a major portion of the increase.

Conclusions
Among CD patients, suboptimal treatment indicators were common and were associated with an increased burden to the healthcare system.
Novel Budesonide Suppository and Standard Budesonide Rectal Foam Induce High Rates of Clinical Remission and Mucosal Healing in Active Ulcerative Proctitis: a Randomised, Controlled, Non-inferiority Trial
Authors: Kruis Wolfgang , Siegmund Britta , Lesniakowski Konrad , Simanenkov Vladimir , Khimion Ludmila , Sobon Marcin , Delmans Glebs , Maksyashina Svetlana V , Sablin Oleg A , Pokrotnieks Juris , Mostovoy Yuriy , Datsenko Olena , Abdulkhakov Sayar , Dorofeyev Andriy , Levchenko Olena , Alexeeva Olga , Andreev Pavel , Kolesnik Ivan P , Mihaly Emese , Abrahamovych Orest , Baluta Malgorzata , Kharchenko Nataliia , Viacheslav Neshta , Uspenskiy Yury , Vieth Michael , Mohrbacher Ralf , Mueller Ralph , Greinwald Roland 
Published: June 2022

Abstract

Background and Aims
Proctitis is the least extensive type of ulcerative colitis, for which rectal therapy is rarely studied and is underused. This study evaluated the efficacy, safety, and patient’s preference of a novel formulation of budesonide suppository 4 mg, compared with a commercially available budesonide rectal foam 2 mg, for the treatment of mild to moderate ulcerative proctitis.

Methods
This was a randomised, double-blind, double-dummy, active-controlled trial. Patients were randomly assigned in a 1:1 ratio to receive either budesonide 4 mg suppository or budesonide 2 mg foam once daily for 8 weeks. The co-primary endpoints were changes from baseline to Week 8 in clinical symptoms, for which clinical remission was defined as having a modified Ulcerative Colitis-Disease Activity Index [UC-DAI] subscore for stool frequency of 0 or 1 and a subscore for rectal bleeding of 0, and mucosal healing, defined as having a modified UC-DAI subscore for mucosal appearance of 0 or 1. Using a more stringent criterion, we additionally analysed deepened mucosal healing, which was defined as a mucosal appearance subscore of 0. Patient’s preference, physician’s global assessment, and quality of life were also assessed and analysed.

Results
Overall, 286 and 291 patients were included in the 4 mg suppository and 2 mg foam groups, respectively. Budesonide 4 mg suppository met the prespecified criterion for non-inferiority to the 2 mg foam in both co-primary endpoints of clinical remission and mucosal healing. Secondary endpoints consistently supported the non-inferiority of the suppository. Trends in favour of the suppository were observed in the subgroup of mesalazine non-responders. More patients reported a preference for the suppository over rectal foam.

Conclusions
In patients with ulcerative proctitis, budesonide 4 mg suppository was non-inferior to budesonide 2 mg foam in efficacy, and both were safe and well tolerated.
Percutaneous closure of a paravalvular leak from a prosthetic mitral valve dehiscence in a young high-risk patient: case report
Authors: Ozden Ozge , Kemal Hatice , Bingöl Gülsüm , Göktekin Ömer 
Published: June 2022

Abstract

Background
Paravalvular leak (PVL) is a common, serious complication related with prosthetic valve replacement. Although surgical closure reoperation is the choice of treatment, percutaneous device closure is a good alternative with good results in patients with very high surgical risk.

Case summary
In this case report, we present the percutaneous closure of PVL of mitral valve replacement (MVR), in a patient with cardiogenic shock who failed conservative medical treatment and was deemed inoperable due to recurrent operations. Successful closure of the PVL with the use of the four consecutive PVL closure devices was performed under general anaesthesia with guidance of 2D and 3D transoesophageal echocardiography. The procedure was performed with no complications and the patient has remained asymptomatic after 10 months following the PVL closure procedure with marked improvement in her NYHA class and echocardiographic values.

Discussion
Percutaneous PVL closure is a very challenging and high clinical skills requiring procedure, but has a good success and low complication rate in high-risk patients. It is not a standard procedure and the type and size of device should be tailored for each patient with a good 2D and 3D echocardiographic guidance.
The View from here – Teaching ‘Popular’ Nationalism in English
Authors: Bhattacharya Saradindu 
Published: June 2022

Abstract
This essay situates the academic enquiry into the ‘popular’ idea of the nation within the shifting disciplinary contours of English in India. Using the iconic Bharatbala music video ‘Vande Mataram’ (1998) as a case study, it demonstrates how methods of analysis derived from literary studies may be used to engage with the mediated nature of contemporary culture; the classroom experience of ‘reading’ together a popular cultural text reflects as well as instantiates the expansion of ‘English’ at the level of both content and form. The collaborative pedagogic exercise of decoding the ‘signs’ that constitute the audio-visual text through familiar literary terms such as imagery, symbolism, setting and character reveals how the cultural discourse of nationalism – in terms of its historical legacy as well as its current political resonance – can be ‘read’ contextually using disciplinary methods of ‘English’. I argue that the ‘literary’ can no longer be defined only in terms of the nature of the text one brings into the classroom – it is a mode of analysis that can be extended to examining cultural texts in other media formats too, especially if the enterprise of ‘doing’ English in a formal, academic set-up is to be anything more than a reiteration of the value of Anglo-American canonical literature. If the English canon has traditionally been a means of teaching students how to ask fundamental questions about cultural representation, the same aim is now achieved also through the use of texts from other, more familiar and local contexts and media.
Life-course income trajectories of men and women in Norway: implications for self-rated health in later life
Authors: Veenstra Marijke , Aartsen Marja 
Published: June 2022

Abstract

Background
Socioeconomic inequalities in health are well-established, but studies addressing lagged effects of income or of fluctuations in income over the life course are relatively rare. The current study aims to (i) identify and describe life-course income trajectories for men and women who are currently in later life; and (ii) assess the association of income trajectories with self-rated health in older adults.

Methods
The study sample consisted of 1625 men and 1634 women born between 1937 and 1955 who participated in the third wave of the Norwegian Life course, Ageing and Generation Study. Latent class growth analyses were used to estimate dominant income trajectories from ages 30 through 62 in men and women. Stepwise logistic regression analyses were specified to analyze the association of income trajectories with self-rated health in later life.

Results
Four trajectories in women and three trajectories in men were estimated as dominant patterns of income over the life course. Differences in the level of income were considerable at age 30 and accumulated over time. Continued exposure to low income showed statistically significant higher odds for poor self-rated health in older men and women. This association remained significant after taking differences in educational attainment, working life, family formation and accumulated wealth into account.

Conclusion
The findings suggested remarkable rigidity in income groups that had formed by age 30. A significant share of men and women remain mired in relatively low-income status across the life course with negative implications for health in later life.
CaveCrawler: an interactive analysis suite for cavefish bioinformatics
Authors: Perry Annabel , McGaugh Suzanne E , Keene Alex C , Blackmon Heath 
Published: June 2022

Abstract
The growing use of genomics in diverse organisms provides the basis for identifying genomic and transcriptional differences across species and experimental conditions. Databases containing genomic and functional data have played critical roles in the development of numerous genetic models but most emerging models lack such databases. The Mexican tetra, Astyanax mexicanus exists as 2 morphs: surface-dwelling and cave-dwelling. There exist at least 30 cave populations, providing a system to study convergent evolution. We have generated a web-based analysis suite that integrates datasets from different studies to identify how gene transcription and genetic markers of selection differ between populations and across experimental contexts. Results of diverse studies can be analyzed in conjunction with other genetic data (e.g. Gene Ontology information), to enable biological inference from cross-study patterns and identify future avenues of research. Furthermore, the framework that we have built for A. mexicanus can be adapted for other emerging model systems.
Isha is a su(Hw) mRNA-binding protein required for gypsy insulator function
Authors: Bag Indira , Chen Yang , D'Orazio Karole , Lopez Prisma , Wenzel Sabine , Takagi Yuichiro , Lei Elissa P 
Published: June 2022

Abstract
Chromatin insulators are DNA–protein complexes localized throughout the genome capable of establishing independent transcriptional domains. It was previously reported that the Drosophila su(Hw) mRNA physically associates with the gypsy chromatin insulator protein complex within the nucleus and may serve a noncoding function to affect insulator activity. However, how this mRNA is recruited to the gypsy complex is not known. Here, we utilized RNA-affinity pulldown coupled with mass spectrometry to identify a novel RNA-binding protein, Isha (CG4266), that associates with su(Hw) mRNA in vitro and in vivo. Isha harbors a conserved RNA recognition motif and RNA Polymerase II C-terminal domain-interacting domain (CID). We found that Isha physically interacts with total and elongating Polymerase II and associates with chromatin at the 5′ end of genes in an RNA-dependent manner. Furthermore, ChIP-seq analysis reveals Isha overlaps particularly with the core gypsy insulator component CP190 on chromatin. Depletion of Isha reduces enhancer-blocking and barrier activities of the gypsy insulator and disrupts the nuclear localization of insulator bodies. Our results reveal a novel factor Isha that promotes gypsy insulator activity that may act as a nuclear RNA-binding protein adapter for su(Hw) noncoding mRNA.
O-GlcNAc transferase maintains metabolic homeostasis in response to CDK9 inhibition
Authors: Gondane Aishwarya , Poulose Ninu , Walker Suzanne , Mills Ian G , Itkonen Harri M 
Published: June 2022

Abstract
Co-targeting of O-GlcNAc transferase (OGT) and the transcriptional kinase cyclin-dependent kinase 9 (CDK9) is toxic to prostate cancer cells. As OGT is an essential glycosyltransferase, identifying an alternative target showing similar effects is of great interest. Here, we used a multiomics approach (transcriptomics, metabolomics, and proteomics) to better understand the mechanistic basis of the combinatorial lethality between OGT and CDK9 inhibition. CDK9 inhibition preferentially affected transcription. In contrast, depletion of OGT activity predominantly remodeled the metabolome. Using an unbiased systems biology approach (weighted gene correlation network analysis), we discovered that CDK9 inhibition alters mitochondrial activity/flux, and high OGT activity is essential to maintain mitochondrial respiration when CDK9 activity is depleted. Our metabolite profiling data revealed that pantothenic acid (vitamin B5) is the metabolite that is most robustly induced by both OGT and OGT+CDK9 inhibitor treatments but not by CDK9 inhibition alone. Finally, supplementing prostate cancer cell lines with vitamin B5 in the presence of CDK9 inhibitor mimics the effects of co-targeting OGT and CDK9.
Premature transcription termination at the expanded GAA repeats and aberrant alternative polyadenylation contributes to theFrataxintranscriptional deficit in Friedreich’s ataxia
Authors: Li Yanjie , Li Jixue , Wang Jun , Zhang Siyuan , Giles Keith , Prakash Thazha P , Rigo Frank , Napierala Jill S , Napierala Marek 
Published: June 2022

AbstractFrataxin deficiency in Friedreich’s ataxia results from transcriptional downregulation of the FXN gene caused by expansion of the intronic trinucleotide guanine-adenine-adenine (GAA) repeats. We used multiple transcriptomic approaches to determine the molecular mechanism of transcription inhibition caused by long GAAs. We uncovered that transcription of FXN in patient cells is prematurely terminated upstream of the expanded repeats leading to the formation of a novel, truncated and stable RNA. This FXN early terminated transcript (FXN-ett) undergoes alternative, non-productive splicing and does not contribute to the synthesis of functional frataxin. The level the FXN-ett RNA directly correlates with the length of the longer of the two expanded GAA tracts. Targeting GAAs with antisense oligonucleotides or excision of the repeats eliminates the transcription impediment, diminishes expression of the aberrant FXN-ett, while increasing levels of FXN mRNA and frataxin. Non-productive transcription may represent a common phenomenon and attractive therapeutic target in diseases caused by repeat-mediated transcription aberrations.
Wargames Resurgent: The Hyperrealities of Military Gaming from Recruitment to Rehabilitation
Authors: Hirst Aggie 
Published: June 2022

Abstract
While games are commonly viewed as frivolous fun, their rapid proliferation across the US defense establishment compels us to think again. Spanning spheres as diverse as total immersion training, near-peer/cyber conflict, and future force strategies, a gaming renaissance is currently underway across the US military. Surprisingly, given international relations’ (IR) interest in the production and projection of military power, the discipline has neglected to engage with this revival. This article argues that hyperreal games—that is, games that produce realities—play an increasingly important role in the attraction, production, management, and recovery of warfighters. Drawing upon one hundred hours of interviews undertaken with US military games designers, trainers, trainees, and veterans between 2017 and 2019, the article documents first-hand experiences of hyperreal gaming in warfighter recruitment, training, deployment, and rehabilitation. The core argument developed is that unlike simulations, which model scenarios, games are productive of people, values, and identity. If it is to understand games’ use as a tool of warfighter subjectification, the article argues, IR must renew its focus on military gaming disaggregated from the broader hyperrealities of modeling, simulation, and exercises with which it has hitherto been conflated.
How Do Economic Sanctions Affect Public Opinion and Consumer Behavior in Target States? Evidence from China's Economic Sanctions on South Korea
Authors: Sung Rena , Park Jonghyuk 
Published: June 2022

Abstract
Previous research shows that economic sanctions affect three facets of public opinion in target states: support for the policy at issue, support for the target government, and hostility toward the sanctioner. We explore the dynamics between the facets of opinion and link them to consumer behavior. How do supportive opinions of the policy and the target government lead to hostility? How does this hostility affect consumers’ propensity to buy the sanctioner's branded products? We examine a case in which China imposed economic sanctions on South Korea in opposition to South Korea's decision to deploy Terminal High Altitude Area Defense. We collect comments from relevant newspaper articles and conduct attitude analysis using machine learning. We conduct difference-in-differences analyses using barcode-level data regarding monthly beer sales, for which we argue boycotts are more likely to occur. We find that a backlash effect in public opinion occurred with respect to two facets of opinion. However, despite the public antagonism, we observe no significant backlash in consumer behavior. These findings imply that effects of economic sanctions in target states are multidimensional and thus it is too simplistic to assess the effectiveness of economic sanctions only by looking at public opinion in target states.