bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Asthma and Reduced Androgen Receptor Expression in Airways
Authors: McManus Jeffrey M , Gaston Benjamin , Zein Joe , Sharifi Nima 
Published: March 2022

AbstractA growing body of evidence suggests a role for androgens in asthma and asthma control. This includes a sex discordance in disease rates that changes with puberty, experiments in mice showing androgens reduce airway inflammation, and a reported association between airway androgen receptor (AR) expression and disease severity in asthma patients. We set out to determine whether airway AR expression differs between asthma patients and healthy controls. We analyzed data from 8 publicly available data sets with gene expression profiling from airway epithelial cells obtained both from asthma patients and control individuals. We found that airway AR expression was lower in asthma patients than in controls in both sexes, and that having AR expression below the median in the pooled data set was associated with substantially elevated odds of asthma vs having AR expression above the median (odds ratio 4.89; 95% CI, 3.13-7.65, P &lt; .0001). In addition, our results suggest that whereas the association between asthma and AR expression is present in both sexes in most of the age range analyzed, the association may be absent in prepubescent children and postmenopausal women. Our results add to the existing body of evidence suggesting a role for androgens in asthma control.
Archaeology, Wage Labor, and Kinship in Rural Mexico, 1934–1974
Authors: Holley-Kline Sam 
Published: March 2022

Abstract
This article assesses the relationships between archaeology and wage labor in twentieth-century Mexico through an analysis of governmental payroll records from El Tajín, Veracruz. For Indigenous Totonac workers, the long-term presence of archaeological labor provided opportunities for income and social mobility in a context of dispossession and proletarianization while contributing to socioeconomic stratification. In a region where the traditional agricultural base declined during the twentieth century, participation in wage labor provided a source of regular cash income and opportunities for skill development and social mobility. Participation, however, depended on intermediaries and their kin and social networks, meaning that not all had access. The analysis suggests that state-run archaeology must be understood in practical and economic terms as well as in a regional context.
“We're Here! We're Queer! Fuck the Banks!”
Authors: Reed Alison Rose 
Published: March 2022

Abstract
Literalizing the metaphor of José Esteban Muñoz's famous statement, “Queerness is not yet here. . . . The here and now is a prison house,” this essay argues that the process of affectively reorienting space and minds toward abolition is a queer act. It posits that abolition and queerness overlap in their refusal to maintain faith in institutions to effect change, specifically through legal reforms that redouble the status quo while shunning broader visions of liberation. Queer abolitionist affects reorient space toward decolonial futures by challenging normative paradigms of power and its critique. In messy and imperfect ways, a queer abolitionist analysis understands love and collectivity more capaciously beyond the nuclear family unit to social relations not of domination but of transformation. By exploring the affective dimensions of queer abolition, this essay takes up the spatial and symbolic relationship between the Pride parade and the prison industrial complex. It brings together an analysis of public protest against the colonial-carceral state and prison education, specifically the Humanities Behind Bars program, in order to engage how queer affects strengthen and sustain the relationships so vital to abolitionist world making.
Delayed Presentations and Worse Outcomes After Aneurysmal Subarachnoid Hemorrhage in the Early COVID-19 Era
Authors: Akbik Feras , Yang Chris , Howard Brian M. , Grossberg Jonathan A. , Danyluk Lisa , Martin Kathleen S. , Alawieh Ali , Rindler Rima S. , Tong Frank C. , Barrow Daniel L. , Cawley C. Michael , Samuels Owen B. , Sadan Ofer 
Published: March 2022

BACKGROUND:
The early phase of the COVID-19 pandemic led to significant healthcare avoidance, perhaps explaining some of the excess reported deaths that exceeded known infections. The impact of the early COVID-19 era on aneurysmal subarachnoid hemorrhage (aSAH) care remains unclear.

OBJECTIVE:
To determine the impact of the early phase of the COVID-19 pandemic on latency to presentation, neurological complications, and clinical outcomes after aSAH.

METHODS:
We performed a retrospective cohort study from March 2, 2012, to June 30, 2021, of all patients with aSAH admitted to our center. The early COVID-19 era was defined as March 2, 2020, through June 30, 2020. The pre–COVID-19 era was defined as the same interval in 2012 to 2019.

RESULTS:
Among 499 patients with aSAH, 37 presented in the early COVID-19 era. Compared with the pre–COVID-19 era patients, patients presenting during this early phase of the pandemic were more likely to delay presentation after ictus (median, interquartile range; 1 [0-4] vs 0 [0-1] days, respectively, P < .001). Radiographic-delayed cerebral ischemia (29.7% vs 10.2%, P < .001) was more common in the early COVID-19 era. In adjusted analyses, presentation in the early COVID-19 era was independently associated with increased inhospital death or hospice disposition (adjusted odds ratio 3.29 [1.02–10.65], P = .046). Both latency and adverse outcomes returned to baseline in 2021.

CONCLUSION:
aSAH in the early COVID-19 era was associated with delayed presentation, neurological complications, and worse outcomes at our center. These data highlight how healthcare avoidance may have increased morbidity and mortality in non–COVID-19-related neurosurgical disease.
Molecular contribution to embryonic aneuploidy and karyotypic complexity in initial cleavage divisions of mammalian development
Authors: Brooks Kelsey E. , Daughtry Brittany L. , Davis Brett , Yan Melissa Y. , Fei Suzanne S. , Shepherd Selma , Carbone Lucia , Chavez Shawn L. 
Published: March 2022

ABSTRACT
Embryonic aneuploidy is highly complex, often leading to developmental arrest, implantation failure or spontaneous miscarriage in both natural and assisted reproduction. Despite our knowledge of mitotic mis-segregation in somatic cells, the molecular pathways regulating chromosome fidelity during the error-prone cleavage-stage of mammalian embryogenesis remain largely undefined. Using bovine embryos and live-cell fluorescent imaging, we observed frequent micro-/multi-nucleation of mis-segregated chromosomes in initial mitotic divisions that underwent unilateral inheritance, re-fused with the primary nucleus or formed a chromatin bridge with neighboring cells. A correlation between a lack of syngamy, multipolar divisions and asymmetric genome partitioning was also revealed, and single-cell DNA-seq showed propagation of primarily non-reciprocal mitotic errors. Depletion of the mitotic checkpoint protein BUB1B (also known as BUBR1) resulted in similarly abnormal nuclear structures and cell divisions, as well as chaotic aneuploidy and dysregulation of the kinase-substrate network that mediates mitotic progression, all before zygotic genome activation. This demonstrates that embryonic micronuclei sustain multiple fates, provides an explanation for blastomeres with uniparental origins, and substantiates defective checkpoints and likely other maternally derived factors as major contributors to the karyotypic complexity afflicting mammalian preimplantation development.
Svep1 stabilises developmental vascular anastomosis in reduced flow conditions
Authors: Coxam Baptiste , Collins Russell T. , Hußmann Melina , Huisman Yvonne , Meier Katja , Jung Simone , Bartels-Klein Eireen , Szymborska Anna , Finotto Lise , Helker Christian S. M. , Stainier Didier Y. R. , Schulte-Merker Stefan , Gerhardt Holger 
Published: March 2022

ABSTRACTMolecular mechanisms controlling the formation, stabilisation and maintenance of blood vessel connections remain poorly defined. Here, we identify blood flow and the large extracellular protein Svep1 as co-modulators of vessel anastomosis during developmental angiogenesis in zebrafish embryos. Both loss of Svep1 and blood flow reduction contribute to defective anastomosis of intersegmental vessels. The reduced formation and lumenisation of the dorsal longitudinal anastomotic vessel (DLAV) is associated with a compensatory increase in Vegfa/Vegfr pERK signalling, concomittant expansion of apelin-positive tip cells, but reduced expression of klf2a. Experimentally, further increasing Vegfa/Vegfr signalling can rescue the DLAV formation and lumenisation defects, whereas its inhibition dramatically exacerbates the loss of connectivity. Mechanistically, our results suggest that flow and Svep1 co-regulate the stabilisation of vascular connections, in part by modulating the Vegfa/Vegfr signalling pathway.
Thyroid cancer incidences in the United Arab Emirates: a retrospective study on association with age and gender
Authors: Almansoori Asma , Busch Hauke , Bendardaf Riyad , Hamoudi Rifat 
Published: March 2022

Background: Thyroid cancer is the ninth most common malignancy worldwide, but the third most common malignancy in the United Arab Emirates (UAE). To our knowledge, this is the first UAE nationwide study aimed at presenting incidence rates of thyroid cancer at the national level of UAE based upon data from the national cancer registry and GLOBOCAN. Methods: Between 2011 and 2017, a total of 2036 thyroid cancer cases from UAE patients were registered, of which 75.3% were female and 24.7% male patients. Results: The results showed 6.6% increase in thyroid cancer cases in the UAE from 2011 to 2017 (p < 0.001) with a rise of approximately 400 cases per year from 2011 to 2040. Age standardized rate calculations showed increase in prevalence from 1.18 in 2011 to 4.32 in 2017 but decreases in incidence from 1.05 in 2011 to 0.15 in 2017. This trend is confirmed by the predictive model showing increase in incidence from 0.15 in 2017 to 0.64 by 2040. Gender was shown to be significantly associated with thyroid cancer. The female to male ratio was significantly higher in Emirati patients (4.86:1) (p < 0.001) than expat patients (2.47:1) (p < 0.01). Interestingly, expat patients contributed to the majority of thyroid cancer cases despite having lower female to male ratio. The age at diagnosis was significantly associated with thyroid cancer (p = 0.03) with the highest frequency diagnosed at 35-39 years of age. Globally, data from the predictive model showed that Asia had the highest rate of increase per year and UAE the lowest. Conclusions: The slight increase in thyroid cancer prevalence and incidence, together with the different female to male ratio and diagnosis at younger age warrants further investigation at the molecular level from UAE thyroid cancer patients to elucidate the molecular basis of thyroid cancer.
Methodological approaches for developing and reporting living evidence synthesis: a study protocol
Authors: Auladell-Rispau Ariadna , Bendersky Josefina , Santafe Angie , Buchanan Cecilia , Rigau Comas David , Verdugo Francisca , Ávila Camila , Alonso Pablo , Urrutia Gerard , Rada Gabriel , Rojas-Reyes María Ximena 
Published: March 2022

Background: Living evidence (LE) refers to the methodological processes that permit new research findings to be continually incorporated into evidence synthesis. This approach is of great value in the resolution of relevant and rapidly changing clinical questions. To date, the methods to carry out this type of synthesis are not completely defined, and great variability is observed in the approaches used by different groups of authors. Objective: To identify, evaluate and summarise the current methods used for living evidence synthesis Methods: We will conduct a methodological study based on a systematic literature search to identify any type of evidence synthesis such as systematic reviews, network metanalyses and overviews that used “living evidence synthesis” as part of their methods. The search will be conducted in Medline (via PubMed) and Epistemonikos databases. Additionally, we will search websites of the organisations publishing any living evidence synthesis retrieved in the two databases, in order to identify unpublished subsequent reports. Two reviewers will independently assess each article against the selection criteria, extract data on methods and procedures, and assess the methodological quality of each publication. Data will be analysed descriptively.
Promotion of data sharing needs more than an emergency: An analysis of trends across clinical trials registered on the International Clinical Trials Registry Platform
Authors: Merson Laura , Ndwandwe Duduzile , Malinga Thobile , Paparella Giuseppe , Oneil Kwame , Karam Ghassan , Terry Robert F. 
Published: March 2022

BACKGROUND: A growing body of evidence shows that sharing health research data with other researchers for secondary analyses can contribute to better health. This is especially important in the context of a public health emergency when stopping a pandemic depends on accelerating science. METHODS: We analysed the information on data sharing collected by the 18 clinical trial registries included in the WHO International Clinical Trials Registry Platform (ICTRP) to understand the reporting of data sharing plans and which studies were and were not planning to share data. Data on sponsor and funder organisations, country of recruitment, registry, and condition of study were standardised to compare the sharing of information and data across these facets. This represents the first ever comprehensive study of the complete data set contained in ICTRP. RESULTS: Across 132,545 studies registered between January 2019 and December 2020, 11.2% of studies stated that individual patient data (IPD) would be shared. Plans to share IPD varied across the 18 contributing registries– information on data sharing was missing in >95% of study records across 7/18 registries. In the 26,851 (20.3%) studies that were funded or sponsored by a commercial entity, intention to share IPD was similar to those that were not (11.5% vs 11.2%). Intention to share IPD was most common in studies recruiting across both high-income and low- or middle-income countries (21.4%) and in those recruiting in Sub-Saharan Africa (50.3%). Studies of COVID-19 had similar levels of data sharing to studies of other non-pandemic diseases in 2020 (13.7% vs 11.7%). CONCLUSIONS: Rates of planned IPD sharing vary between clinical trial registries and economic regions, and are similar whether commercial or non-commercial agencies are involved. Despite many calls to action, plans to share IPD have not increased significantly and remain below 14% for diseases causing public health emergencies.
Characterising the persistence of RT-PCR positivity and incidence in a community survey of SARS-CoV-2
Authors: Eales Oliver , Walters Caroline E. , Wang Haowei , Haw David , Ainslie Kylie E. C. , Atchison Christina J. , Page Andrew J. , Prosolek Sophie , Trotter Alexander J. , Le Viet Thanh , Alikhan Nabil-Fareed , Jackson Leigh M. , Ludden Catherine ,   COVID-19 Genomics UK Consortium, Ashby Deborah , Donnelly Christl A. , Cooke Graham , Barclay Wendy , Ward Helen , Darzi Ara , Elliott Paul , Riley Steven 
Published: March 2022

Background:The REal-time Assessment of Community Transmission-1 (REACT-1) study has provided unbiased estimates of swab-positivity in England approximately monthly since May 2020 using RT-PCR testing of self-administered throat and nose swabs. However, estimating infection incidence requires an understanding of the persistence of RT-PCR swab-positivity in the community.Methods:During round 8 of REACT-1 from 6 January to 22 January 2021, we collected up to two additional swabs from 896 initially RT-PCR positive individuals approximately 6 and 9 days after their initial swab.Results:Test sensitivity and duration of positivity were estimated using an exponential decay model, for all participants and for subsets by initial N-gene cycle threshold (Ct) value, symptom status, lineage and age. A P-spline model was used to estimate infection incidence for the entire duration of the REACT-1 study. REACT-1 test sensitivity was estimated at 0.79 (0.77, 0.81) with median duration of positivity at 9.7 (8.9, 10.6) days. We found greater duration of positivity in those exhibiting symptoms, with low N-gene Ct values, or infected with the Alpha variant. Test sensitivity was found to be higher for those who were pre-symptomatic or with low N-gene Ct values. Compared to swab-positivity, our estimates of infection incidence included sharper features with evident transient increases around the time of changes in social distancing measures.Conclusions:These results validate previous efforts to estimate incidence of SARS-CoV-2 from swab-positivity data and provide a reliable means to obtain community infection estimates to inform policy response.
SOMATOFORM DYSFUNCTION OF THE AUTONOMIC NERVOUS SYSTEM IN ADOLESCENTS: VEGETATIVE HOMEOSTASIS AND ERYTHROCYTE MEMBRANE REACTIVITY
Authors: Zaitseva Zhanna G. , Zaitseva Olga I. , Kolodyazhnaya Tatyana A. 
Published: March 2022

Aim. To study autonomic homeostasis and reactivity of erythrocyte membranes to bioregulators of the autonomic nervous system in adolescents with somatoform dysfunction of the autonomic nervous system to predict the course of the disease and assess adaptive capabilities.
Materials and methods. Clinical, instrumental and laboratory examination of adolescents with somatoform dysfunction of the autonomic nervous system and healthy adolescents was carried out.
Results. In adolescents with somatoform dysfunction of the autonomic nervous system, dysregulatory types of autonomic response were revealed at the level of erythrocyte membranes. Significant biophysical risk factors for the paroxysmal course of the disease have been identified: low peak and rate fluorescence values with acetylcholine, as well as low peak fluorescence values with adrenaline.
Conclusion. Identification of autonomic dysregulation at the level of cell membranes in adolescents with somatoform dysfunction of the autonomic nervous system is an important factor determining the course of the disease, as well as the adaptive capabilities of the adolescent’s body. Establishment of significant membrane risk factors for a complicated course of the disease is necessary for a personalized approach to the implementation of therapeutic and prophylactic measures.
AGE-DEPENDENT VARIABILITY OF THE DYNAMICS OF LINEAR GROWTH OF SALIX TRIANDRA SHOOTS
Authors: Afonin Alexey A. 
Published: March 2022

Salix triandra (almond willow) is an established crop, grown for basket-making materials. This species is also used for a wide range of environmental projects. The paper aimed to comparative analysis of the seasonal dynamics of linear growth of shoots in S. triandra clones on stools of different ages. The object of the study is a model inbred-clonal population of S. triandra. Our study analyzed the growing annual shoots on saplings from cuttings. To obtain the material, one- and two-year-old stools of four clones were used. The observations were carried out in the conditions of the vegetative period in the year 2021. The development of shoots occurred in conditions of extremely excessive atmospheric moisture at the beginning of the growing season. The study also assessed the impact of ruderal vegetation.
As a result of our observations, it was found that the length of shoots on annual stools reached 210-220 cm, on biennial stools – 300-340 cm. The average daily increment of shoots on annual stools was 2.01±0.052 cm/day (with a maximum of 3.8-4.4 cm/day), on biennial stools – 2.88±0.069 cm/day (with a maximum of 5.0-6.1 cm/day). The root mean square amplitude of oscillation in the daily growth of shoots on annual stools was 0.79 cm/day, on biennial stools – 1.34 cm/day. The results showed that, regardless of the age of the stool, there is a cyclic development of shoots, which is due to the alternation of the maximum and minimum daily growth. The greatest degree of synchronization of maximum and minimum values of daily shoots increment in spring and early summer is revealed. A clone has been identified that gives consistently high increment of shoots. It is recommended to use such clones to create sustainable and multifunctional crops of almond willow.
Grado de información percibida por los tutores legales en el Consentimiento Informado en el servicio de Neumología y Alergia Infantil
Authors: Jang Dah Tay , Oishi Konari Miriam Natsuki , Costa Daalmans Irene , Mazón Ramos Ángel 
Published: March 2022

Introducción: Existe escasa información sobre el grado de información percibida por los tutores legales en el Consentimiento informado (CI) en el ámbito pediátrico. Objetivos: Evaluar el grado de información percibida por los tutores legales en el CI de pruebas de provocación en Alergia Pediátrica. Métodos y Materiales: Estudio descriptivo, observacional y transversal de valoración de información mediante cuestionario, en el período de abril-mayo de 2021. El cuestionario fue desarrollado por el autor y su equipo, tomando como base un cuestionario disponible en la literatura. Se realizó estudio estadístico descriptivo y analítico mediante el software SPSS 15.0. Resultados: Se reclutaron 99 tutores con una edad media de 41 años, con formación universitaria 52%, profesional 27%, secundaria 17% y primaria 4%. Más del 70% de la muestra calificó positivamente el grado de información proporcionada en relación al procedimiento, su objetivo, su riesgo-beneficio y el tiempo de dedicación y de decisión. Un 50% de los tutores calificó negativamente la información proporcionada en cuanto al tratamiento alternativo, posibilidad de negar y revocar el CI. La consistencia interna del cuestionario fue muy buena, con un valor de la alfa de Cronbach de 0.88. No se encontró correlación entre el grado de percepción y diversas variables demográficas o clínicas. Conclusiones: El grado de información percibida por los tutores es en general muy bueno. Las informaciones en relación a los procedimientos alternativos, la posibilidad de rechazo y revocación del CI fueron los puntos mejorables.