bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated cardiovascular disease risk in low-income women with a history of pregnancy loss
Authors: Tsulukidze Maka , Reardon David , Craver Christopher 
Published: June 2022

ObjectivePregnancy is associated with elevated risk of cardiovascular diseases (CVD), but little is known regarding the association between CVD and specific types of pregnancy losses. The aim of this study is to investigate the effects of pregnancy loss on the risk of subsequent CVD of any type.MethodsThis prospective longitudinal study examines medical records between 1999 and 2014 for Medicaid beneficiaries born after 1982 who lived in a state that funds all reproductive health services, including induced abortion. Unique pregnancy outcomes, history of diabetes, hyperlipidaemia or CVD (International Classification of Diseases, Ninth Revision (ICD-9): 401–459) prior to their first pregnancy outcome for each woman. Cumulative incidence rates of a first CVD diagnosis following a first pregnancy were calculated for the observed period, exceeding 12 years.ResultsA history of pregnancy loss was associated with 38% (OR=1.38; 95% CI=1.37 to 1.40) higher risk of a CVD diagnosis in the period observed. After controlling for history of diabetes, hyperlipidaemia, age, year of first pregnancy, race, state of residence, months of eligibility, number of pregnancies, births, number of losses before and after the first live birth, exposure to any pregnancy loss was associated with an 18% (adjusted OR=1.18; 95% CI=1.15 to 1.21) increased risk of CVD. Our analyses also reveal an important temporal relationship between the CVD and pregnancy loss. Immediate and short-term increased CVD risk is more characteristic for women whose first pregnancy ended in live birth while a delayed and more prolonged increased risk of CVD is associated with a first pregnancy loss.ConclusionsOur findings corroborate previous research showing that pregnancy loss is an independent risk factor for CVD, especially for diseases more chronic in nature. Our research contributes to understanding the specific needs for cardiovascular health monitoring for pregnant women and developing a consistent, evidence-based screening tools for both short-term and long-term follow-up.
Changes in dental wear and breakage in arctic foxes (Vulpes lagopus) across space and time: evidence for anthropogenic food subsidies?
Authors: Ungar P.S. , Van Valkenburgh B. , Sokolova N. , Fufachev I. , Filippova V. , Shklyar K. , Sokolov A. 
Published: June 2022

Increased human presence in the Arctic may affect its vulnerable ecosystems. Effects on arctic and red foxes provide notable examples. Both have been documented to take anthropogenic subsidies when available, which can change diet and ranging patterns in complex ways that can either benefit or harm populations, depending on the situation. Understanding this complexity requires new tools to study impacts of increasing human presence on endemic mammals at high latitudes. We propose that dental ecology, specifically tooth wear and breakage, can offer important clues. Based on samples of arctic foxes ( Vulpes lagopus (Linnaeus, 1758)) trapped prior to ( n = 78) and following ( n = 57) rapidly growing human presence on the Yamal Peninsula, Russia, we found that foxes trapped recently in proximity to human settlement had significantly less tooth wear and breakage. This is likely explained by a dietary shift from consumption of reindeer ( Rangifer tarandus (Linnaeus, 1758)) carcasses including bone to softer human-derived foods, especially when preferred smaller prey (e.g., West Siberian lemmings, Lemmus sibiricus (Kerr, 1792), and arctic lemmings, Dicrostonyx torquatus (Pallas, 1778)) are unavailable. These results suggest that tooth wear and breakage can be a useful indicator of the consumption of anthropogenic foods by arctic foxes.
The Improved Cooperative Particle Swarm Optimization (ICPSO) with Dynamic Information Adjustment and Controllable Speed and Its Application in Neural Network Optimization
Authors: Fu Li-Hui , Dai Junfeng 
Published: June 2022

In view of the premature convergence of particle swarm optimization (PSO) that is often caused by the loss of diversity, an improved cooperative PSO (ICPSO) is proposed. The method can dynamically combine the optimum values of the particles themselves, the global particles and the optimum values in groups, use the current optimization stage to dynamically adjust the shared proportion of information and effectively fuse various reference information, which can obtain superior global and local optimization performance. Additionally, to improve the diversity of the algorithm, a dynamic adjustment method using the grouping coefficient [Formula: see text] for the convergence rate is put forward. This method makes the algorithm have a more appropriate convergence rate while improving the convergence precision and enhancing the performance of the algorithm. Finally, the algorithm is used to optimize a neural network. The convergence condition and convergence rate of the algorithm are assessed by theoretical analysis and simulation experiments. The results show that ICPSO has more advantages in its diversity and the adjustment of the convergence rate compared to other related algorithms. Regarding neural network optimization, the training speed and optimization precision of the ICPSO-BP neural network are the highest, which has reached the best and average level of classification accuracy 98.5%, 96.3% for 20 iterations in Iris, and 98.7%, 95.1% in Wine. Its average iteration times score the best in five problems out of six.
Intravesical VAX014 Synergizes with PD-L1 Blockade to Enhance Local and Systemic Control of Bladder Cancer
Authors: Tsuji Shingo , Reil Katherine , Nelson Kinsey , Proclivo Veronica H. , McGuire Kathleen L. , Giacalone Matthew J. 
Published: June 2022

Abstract

Emerging clinical evidence indicates that the combination of local administration of immunotherapy with systemic immune-checkpoint blockade targeting the PD-1/PD-L1 pathway improves response rates in select solid tumor indications; however, limited clinical experience with this approach exists in advanced bladder cancer patients. VAX014 is a novel bacterial minicell-based, integrin-targeted oncolytic agent undergoing clinical investigation for intravesical (IVE) treatment of nonmuscle-invasive bladder cancer. Here, we demonstrated that the antitumor activity of VAX014 following IVE administration was dependent upon CD4+ and CD8+ T cells in two syngeneic orthotopic bladder tumor models (MB49 and MBT-2). PD-L1 upregulation was found to be an acquired immune-resistance mechanism in the MB49 model, and the combination of VAX014 with systemic PD-L1 blockade resulted in a significant improvement in bladder tumor clearance rates and development of protective antitumor immunologic memory. Combination treatment also led to enhanced systemic antitumor immune responses capable of clearing distal intradermal tumors and controlling pulmonary metastasis. Distal tumors actively responding to combination therapy demonstrated a phenotypic shift from regulatory T cell to Th1 in intratumoral CD4+ T cells, which was accompanied by a higher percentage of activated CD8+ T cells and higher IFNγ. Finally, VAX014’s target integrins α3β1 and α5β1 were overexpressed in tumor biopsies from advanced-stage bladder cancer patients, as well as in both the MB49 and MBT-2 orthotopic mouse models of bladder cancer. These collective findings provide a rationale for the clinical investigation of VAX014 and systemic PD-1/PD-L1 blockade in advanced-stage bladder cancer.
TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies
Authors: Carideo Cunniff Elizabeth , Sato Yosuke , Mai Doanh , Appleman Vicky A. , Iwasaki Shinji , Kolev Vihren , Matsuda Atsushi , Shi Judy , Mochizuki Michiyo , Yoshikawa Masato , Huang Jian , Shen Luhua , Haridas Satyajeet , Shinde Vaishali , Gemski Chris , Roberts Emily R. , Ghasemi Omid , Bazzazi Hojjat , Menon Saurabh , Traore Tary , Shi Pu , Thelen Tennille D. , Conlon Joseph , Abu-Yousif Adnan O. , Arendt Christopher , Shaw Michael H. , Okaniwa Masanori 
Published: June 2022

Oncology therapies targeting the immune system have improved patient outcomes across a wide range of tumor types, but resistance due to an inadequate T-cell response in a suppressive tumor microenvironment (TME) remains a significant problem. New therapies that activate an innate immune response and relieve this suppression may be beneficial to overcome this hurdle. TAK-676 is a synthetic novel stimulator of interferon genes (STING) agonist designed for intravenous administration. Here we demonstrate that TAK-676 dose-dependently triggers activation of the STING signaling pathway and activation of type I interferons. Furthermore, we show that TAK-676 is a highly potent modulator of both the innate and adaptive immune system and that it promotes the activation of dendritic cells, natural killer cells, and T cells in preclinical models. In syngeneic murine tumor models in vivo, TAK-676 induces dose-dependent cytokine responses and increases the activation and proliferation of immune cells within the TME and tumor-associated lymphoid tissue. We also demonstrate that TAK-676 dosing results in significant STING-dependent antitumor activity, including complete regressions and durable memory T-cell immunity. We show that TAK-676 is well tolerated, exhibits dose-proportional pharmacokinetics in plasma, and exhibits higher exposure in tumor. The intravenous administration of TAK-676 provides potential treatment benefit in a broad range of tumor types. Further study of TAK-676 in first-in-human phase I trials is ongoing.Significance:TAK-676 is a novel systemic STING agonist demonstrating robust activation of innate and adaptive immune activity resulting in durable antitumor responses within multiple syngeneic tumor models. Clinical investigation of TAK-676 is ongoing.
Replication Stress Defines Distinct Molecular Subtypes Across Cancers
Authors: Takahashi Nobuyuki , Kim Sehyun , Schultz Christopher W. , Rajapakse Vinodh N. , Zhang Yang , Redon Christophe E. , Fu Haiqing , Pongor Lorinc , Kumar Suresh , Pommier Yves , Aladjem Mirit I. , Thomas Anish 
Published: June 2022

Endogenous replication stress is a major driver of genomic instability. Current assessments of replication stress are low throughput precluding its comprehensive assessment across tumors. Here we develop and validate a transcriptional profile of replication stress by leveraging established cellular characteristics that portend replication stress. The repstress gene signature defines a subset of tumors across lineages characterized by activated oncogenes, aneuploidy, extrachromosomal DNA amplification, immune evasion, high genomic instability, and poor survival, and importantly predicts response to agents targeting replication stress more robustly than previously reported transcriptomic measures of replication stress. Repstress score profiles the dual roles of replication stress during tumorigenesis and in established cancers and defines distinct molecular subtypes within cancers that may be more vulnerable to drugs targeting this dependency. Altogether, our study provides a molecular profile of replication stress, providing novel biological insights of the replication stress phenotype, with clinical implications.Significance:We develop a transcriptional profile of replication stress which characterizes replication stress and its cellular response, revealing phenotypes of replication stress across cancer types. We envision the repstress score to serve as an effective discovery platform to predict efficacy of agents targeting replication stress and clinical outcomes.
CURRENT DIAGNOSIS, PREVENTION AND TREATMENT OF DRY SOCKET
Authors: Hutor N. S. 
Published: June 2022

Background. Tooth extraction is the most common surgical intervention in the outpatient practice of a dental surgeon. In most cases, bone wound healing is uncomplicated. However, in some patients the course of healing is complicated by acute inflammatory process of dry socket (alveolar osteitis), the frequency of which increases with increasing trauma of surgery. In dentally healthy patients with typical tooth extraction, dry socket occurs in 2.55%, with difficult – in 9.84%, with atypical extraction of the lower wisdom tooth – in 31.03% of cases. In the presence of diabetes, the incidence of dry socket with typical removal is much higher and according to various authors it is 9.7-13.5%.
Objective. The aim of the research was to study the publications and their analysis on the current diagnosis, prevention and treatment of patients with dry socket.
Methods. Scientific sources were the articles in world periodicals on dental surgery and therapy, microbiology as well as some electronic resources and patents.
Results. At present, many techniques, methods, schemes, compositions for treatment of various forms of dry socket are established. Most often, antibacterial drugs or their combinations with other drugs are used. However, antibacterial drugs do not always have a pronounced anti-inflammatory effect due to the high resistance of the oral microflora. In these cases, contemporary drugs in the form of a composition with long-term antiseptic, anti-inflammatory and analgesic action are rational.
Conclusions. The action of a Flupetsal composition, which contains antimicrobial and immunomodulatory drug flurenizide, was clinically proven for treatment of patients with dry socket; the properties of the available ingredients provide a high disinfectant effect, prevent development of inflammation in the tissues and its transition to purulence. A contemporary effective method of treating patients with dry socket is carried out according to the developed method.
Left-Sided Degenerative Valvular Heart Disease in Type 1 and Type 2 Diabetes
Authors: Rawshani Araz , Sattar Naveed , McGuire Darren K. , Wallström Oskar , Smith Ulf , Borén Jan , Bergström Göran , Omerovic Elmir , Rosengren Annika , Eliasson Björn , Bhatt Deepak L. , Rawshani Aidin 
Published: June 2022

Background:
The role of diabetes in the development of valvular heart disease, and, in particular, the relation with risk factor control, has not been extensively studied.

Methods:
We included 715 143 patients with diabetes registered in the Swedish National Diabetes Register and compared them with 2 732 333 matched controls randomly selected from the general population. First, trends were analyzed with incidence rates and Cox regression, which was also used to assess diabetes as a risk factor compared with controls, and, second, separately in patients with diabetes according to the presence of 5 risk factors.

Results:
The incidence of valvular outcomes is increasing among patients with diabetes and the general population. In type 2 diabetes, systolic blood pressure, body mass index, and renal function were associated with valvular lesions. Hazard ratios for patients with type 2 diabetes who had nearly all risk factors within target ranges, compared with controls, were as follows: aortic stenosis 1.34 (95% CI, 1.31–1.38), aortic regurgitation 0.67 (95% CI, 0.64–0.70), mitral stenosis 1.95 (95% CI, 1.76–2.20), and mitral regurgitation 0.82 (95% CI, 0.79–0.85). Hazard ratios for patients with type 1 diabetes and nearly optimal risk factor control were as follows: aortic stenosis 2.01 (95% CI, 1.58–2.56), aortic regurgitation 0.63 (95% CI, 0.43–0.94), and mitral stenosis 3.47 (95% CI, 1.37–8.84). Excess risk in patients with type 2 diabetes for stenotic lesions showed hazard ratios for aortic stenosis 1.62 (95% CI, 1.59–1.65), mitral stenosis 2.28 (95% CI, 2.08–2.50), and excess risk in patients with type 1 diabetes showed hazard ratios of 2.59 (95% CI, 2.21–3.05) and 11.43 (95% CI, 6.18–21.15), respectively. Risk for aortic and mitral regurgitation was lower in type 2 diabetes: 0.81 (95% CI, 0.78–0.84) and 0.95 (95% CI, 0.92–0.98), respectively.

Conclusions:
Individuals with type 1 and 2 diabetes have greater risk for stenotic lesions, whereas risk for valvular regurgitation was lower in patients with type 2 diabetes. Patients with well-controlled cardiovascular risk factors continued to display higher risk for valvular stenosis, without a clear stepwise decrease in risk between various degrees of risk factor control.
How to interpret algorithmically constructed topical structures of scientific fields? A case study of citation-based mappings of the research specialty of invasion biology
Authors: Held Matthias , Velden Theresa 
Published: June 2022

Abstract
Often, bibliometric mapping studies remain at a very abstract level when assessing the validity or accuracy of the generated maps. In this case study of citation-based mappings of a research specialty, we dig deeper into the topical structures generated by the chosen mapping approaches and examine their correspondence to a sociologically informed understanding of the research specialty in question. Starting from a lexically delineated bibliometric field data set, we create an internal map of invasion biology by clustering the direct citation network with the Leiden algorithm. We obtain a topic structure that seems largely ordered by the empirical objects studied (species and habitat). To complement this view, we generate an external map of invasion biology by projecting the field data set onto the global Centre for Science and Technology Studies (CWTS) field classification. To better understand the representation of invasion biology by this global map, we use a manually coded set of invasion biological publications and investigate their citation-based interlinking with the fields defined by the global field classification. Our analysis highlights the variety of types of topical relatedness and epistemic interdependency that citations can stand for. Unless we assume that invasion biology is unique in this regard, our analysis suggests that global algorithmic field classification approaches that use citation links indiscriminately may struggle to reconstruct research specialties.
Towards theorizing peer review
Authors: Hug Sven E. 
Published: June 2022

Abstract
Academic peer review is seriously undertheorized because peer review studies focus on discovering and confirming phenomena, such as biases, and are much less concerned with explaining, predicting, or controlling phenomena on a theoretical basis. In this paper, I therefore advocate for more theorizing in research on peer review. I first describe the main characteristics of the peer review literature, which focuses mainly on journal and grant peer review. Based on these characteristics, I then argue why theory is useful in research on peer review, and I present some theoretical efforts on peer review. I conclude by encouraging peer review researchers to be more theoretically engaged and outline activities that theoretical work on peer review could involve. This invitation to theory-building complements recent roadmaps and calls that have emphasized that we need to have better access to peer review data, improve research design and statistical analysis in peer review studies, experiment with innovative approaches to peer review, and provide more funding for peer review research.
A case of male filicide in farmed European fallow deer (Dama dama)
Authors: Repnik Anja , Skok Janko 
Published: June 2022

Abstract
Male infanticide is a widespread phenomenon in mammals and is usually directed against non-filial infants. In cervids, reports on male infanticide remain very rare. This article reports a case of male filicide (filial infanticide) in farmed European fallow deer (Dama dama). The conflict between the buck and his male offspring took place at the feeding station during the rut and was recorded on camera. Several times (about 7) a fawn entered the feeding station but was repeatedly chased away by the buck. On the last occasion, the buck struck/stabbed the fawn with his antlers. Post-mortem examination revealed penetrating abdominal trauma with gastrointestinal perforation. This is the first record of male infanticide in fallow deer, although it differs from other cases in cervids where the attacks were clearly intentional. Therefore, we cannot provide a firm explanation, although it was likely a non-adaptive/pathological behaviour under the specific (unnatural) circumstances.
Morphology and mating behaviour in the millipede Megaphyllum unilineatum (C.L. Koch, 1838) (Myriapoda, Diplopoda, Julida) under laboratory conditions
Authors: Vujić Vukica , Milovanović Jelena , Jovanović Zvezdana , Dudić Boris , Makarov Slobodan , Pavković-Lučić Sofija , Ilić Bojan 
Published: June 2022

Abstract
Although morphological variation may have an effect on behaviour, there are only a few studies on julid millipedes in which the influence of the variability of some morphological traits on mating success has been explored. Hence, objectives of this study were to investigate mating behaviour in laboratory conditions and identify traits that could possibly be the target of pre-copulatory selection in the julid species Megaphyllum unilineatum. Behavioural sequences were quantified in three types of tests: a mating arena test, a female choice test, and a male choice test. Although the number of contacts with the first chosen partner (from the mating arena test) was greater than with newly offered individuals in choice tests, values of the sexual selection coefficient did not statistically confirm this preference. In addition, analyses of linear measurements (trunk height and width, length of the whole body, antennae, walking legs, and gonopod flagella) in individuals of different mating status were also conducted, as well as geometric morphometric analyses of size and shape of the antennae, heads, walking legs, and gonopod promeres and opisthomeres in such individuals. Antennal length and shape, head shape, and the walking legs shape, differed significantly, depending on the mating status of females. In males of different mating status, statistical significance was established only in the promere centroid size. The differences in certain behavioural sequences in M. unilineatum are similar to those previously reported in M. bosniense, while such similarity is not detected with respect to morphological variation in the mentioned species.
Bone Tool Proxy Evidence for Coiled Basketry Production in the North African Palaeolithic
Authors: Desmond Abigail 
Published: June 2022

Abstract
Bone tools from Taforalt Cave constitute the largest North African Later Stone Age (LSA) bone tool technocomplex recovered to-date. Use-trace analyses show that the small, pointed forms which dominate the assemblage show microtopographic patterning consistent with ethnographic bone tools used to make coiled basketry. The presence of coiled basketry likely scaffolded emergent cultural forms reflected in increased sedentism, resource intensification, and greater population density at Taforalt. This study explores the relationship between coiled basketry and archaeologically co-occurring technologies. Ethnographic analogies derived from Indigenous Californian groups provide a model for how resource-specific collection, processing, storage, and preparation requirements may have been supported technologically.