bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodality imaging to assess severity and outcome in asymptomatic patients with aortic stenosis: a medium-long term follow-up study
Authors: Zito C , Manganaro R , De Sarro R , Licordari R , Bursi F , Mantovani F , Benfari G , Malagoli A , Bertolacelli Y , D'Angelo T , Antonini-Canterin F , Carerj S , Barbieri A 
Published: October 2022

Abstract

Background
Multimodality imaging approach is becoming more and more common in evaluating the severity and outcome of aortic stenosis (AS).

Aim
To assess the outcome of asymptomatic AS and the usefulness of aortic calcium score (CS) by computed tomography (CT) for solving the dilemma of low flow, low gradients (LFLG) severe AS.

Methods
70 (81.4±8.4 years) prospective asymptomatic patients with AS were followed for 2.77±2.01 years with a trans-thoracic echo (TTE) every 6 months. End-points were all cause mortality, aortic valve replacement (AVR or TAVR), aortic velocity and gradients progression and symptoms occurrence. Prevalence of LFLG-AS was investigated and these patients underwent CT for CS calculation at the end of follow-up (FU), Figure 1.

Results
Baseline TTE results from the 70 pts were: peak velocity 3.1±0.8m/sec; peak gradient 44±21mmHg; mean gradient 26±14 mmHg; AVA 1±0.3 cm2; DVI 0.31±0.1; Svi 33.8±18 ml/m2; EF: 55±9% with an AS being mild in 32.9%, moderate in 28.4%, severe in 27.1%; 36.8% of severe AS were LFLG. During FU, 23 (32.8%) pts died (5.7% LFLG) and 13 (18.5%) underwent AVR/TAVR. Predictors of mortality were aortic gradients (p=0.03), AVA (p=0.008), DVI (p&lt;0.001), pulse pressure (p=0.005) and dilated ascending aorta (p&lt;0001). Predictors of AVR/TAVR were: gradients (p=0.003), peak aortic velocity (p=0.02) and dilated ascendent aorta (p=0.01). The best cut-off to predict survival was AVA = 1 cm2 (100% sensitivity and 80% specificity). In 34 pts ending FU we found an overall progression of AS severity (peak velocity 3.6±0.9m/sec; peak gradient 50±24 mmHg; mean gradient 33±15 mmHg; AVA 0.7±0.3 cm2; DVI 0.25±0.08; Svi 36±10 ml/m2; EF 54±10%; p&lt;0.05 for all vs baseline) with 24 (70.5%) pts with severe AS and 10 (29.5%) with not severe AS. 18 (75%) of progressive severe AS were LFLG, 12 asymptomatic and 6 symptomatic and all underwent CS revealing that AS was not severe in 6 (1233±1123 AU; 622±55 AU/m2) and true severe in 12 (3388±1188 AU; 1858±795 AU/m2; p=0.005 and p=0.002, respectively). Symptomatic severe LFLG AS were all true severe according to CS (Figure 1). Table 1 shows the main CS correlations.

Conclusions
Asymptomatic AS in elderly people is associated with high mortality risk and rapid progression. AVA remains the best predictor of outcome. In severe LFLG AS, calcium score correlates with symptoms occurrence, progression of valve disease, LV hypertrophy and function and also with RV function.

Funding Acknowledgement
Type of funding sources: None.
Revealing the dynamics of magnetosphere, atmosphere, and interior of solar system objects with the Square Kilometre Array
Authors: Kimura Tomoki , Fujii Yuka , Kita Hajime , Tsuchiya Fuminori , Sagawa Hideo ,   SKA-Japan Planetary Science Team
Published: October 2022

Abstract
Bodies such as planets, moons, and asteroids in our solar system are the brightest objects in the low-frequency radio astronomy at ≲10 GHz. The low-frequency radio emissions from our solar system bodies exhibit various observed characteristics in the spectrum, polarization, periodicity, and flux. The observed characteristics are essential probes for explorations of the bodies’ magnetosphere, atmosphere, surface, and even their interior. Generation and propagation theories of the radio emissions associate the characteristics with fundamental physics embedded in the environments: e.g., auroral electron acceleration, betatron acceleration, and atmospheric momentum transfer. Here we review previous studies on the low-frequency radio emissions from our solar system bodies to unveil some outstanding key questions on the dynamics and evolution of the bodies. To address the key questions by the future observations with the Square Kilometre Array (SKA), we made feasibility studies for detection and imaging of the radio emissions. Possible extensions of the solar system observations with SKA to the exoplanets are also proposed in the summary.
An Anisotropic Elastic Solid With an Elliptical Inhomogeneity Under a Non-Uniform In-Plane And Anti-Plane Remote Loading
Authors: Wang Xu , Schiavone Peter 
Published: October 2022

Summary
We consider the case of an anisotropic elastic elliptical inhomogeneity embedded in an infinite anisotropic elastic matrix subjected to a non-uniform remote loading described by remote stresses and strains which are linear functions of the two in-plane coordinates. The internal stresses and strains within the elliptical inhomogeneity are found to be linear functions of the two in-plane coordinates. In addition, we obtain explicit real-form solutions describing the elastic field inside the inhomogeneity as well as hoop stress vectors and hoop stresses on the matrix side and on the inhomogeneity side. We also obtain the corresponding solutions for the two limiting cases in which the elliptical inhomogeneity takes the form of a hole or a rigid inhomogeneity. The solution method presented here can be extended to accommodate the more general scenario in which the remote applied stresses and strains are arbitrary-order polynomials of the two in-plane coordinates.
Is there a role for secondary debulking in ovarian cancer? A review of the current literature
Authors: Krause Danielle , Richardson Debra L. 
Published: October 2022

Purpose of review
Until recently, no data was available from randomized, controlled trials (RCT) to assess the role of secondary cytoreductive surgery (CRS) in the management of recurrent epithelial ovarian cancer. This review highlights results from the three completed RCTs, and other recent literature on this topic.

Recent findings
Both the AGO and iMODEL criteria predict high rates of complete gross resection at the time of secondary CRS. Overall survival (OS) was improved in the surgical arms in both DESKTOP 3 and SOC-1. In contrast, surgery did not improve OS in GOG 213, but greater than 80% of patients received bevacizumab with chemotherapy in GOG 213.

Summary
Secondary cytoreduction for recurrent ovarian cancer can be considered in patients who meet specific criteria. Available data supports improvement in OS for patients not receiving bevacizumab, who achieve complete gross resection. Surgery is harmful to patients with gross residual disease.
Effect of comprehensive nursing intervention for congenital heart disease in children: A meta-analysis
Authors: Ding Xueying , Wen Jiaxuan , Yue Xinxin , Zhao Yudan , Qi Cuiping , Wang Di , Wei Xiuhong 
Published: October 2022

Objectives:
This meta-analysis aimed to assess the impact of nursing interventions (e.g., educational and empathic interviewing, motor exercise, therapeutic play interventions) on the perioperative outcome of children with congenital heart disease (CHD).

Methods:
We searched PubMed, Embase, Web of Science, Scopus, Cochrane, EBSCO, The Chinese National Knowledge Infrastructure, Wan Fang Data and the VIP Chinese Journal Service platform from the date of database creation to August 2021. Our study adhered to the recommendations of the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. RevMan 5.4 and Stata 16.0 were used to complete the meta-analysis.

Results:
This meta-analysis showed that comprehensive nursing intervention reduced both the length of hospital stay (weighted mean difference [WMD] = −1.982, 95%CI [−2.329, −1.634], P < .001) and the related risk of post-operative complications [OR = 0.345, 95%CI (0.225, 0.528), P < .001]. In addition, nursing intervention increased parental satisfaction with the care provided [OR = 0.308, 95%CI (1.923, 6.863), P < .001]. Nursing interventions have also had a positive impact in reducing preoperative anxiety [WMD = −6.721, 95% CI (−7.194, −6.249), P < .001] and postoperative pain [WMD = −7.103, 95% CI (−7.103, −7.663), P < .001] in children.

Conclusions:
This meta-analysis confirms the beneficial effects of comprehensive nursing interventions in terms of reduced complication rates and shorter hospital stays. The effectiveness of comprehensive nursing in reducing anxiety and pain levels was also demonstrated. The findings support the implementation of comprehensive care interventions in the perioperative period for children with CHD to improve clinical outcomes.
Dispersive currents from narrow windows of time explain patterns of population connectivity in an ecologically and economically important fish
Authors: Schraidt Claire , Ackiss Amanda S. , Larson Wesley A. , Rowe Mark D. , Höök Tomas O. , Christie Mark R. 
Published: October 2022

AbstractIdentifying the drivers of population connectivity remains a fundamental question in ecology and evolution. Answering this question can be challenging in aquatic environments where dynamic lake and ocean currents, high variance in reproductive success, and above average rates of dispersal and gene flow can increase noise. We developed a novel, integrative approach that couples detailed biophysical models with eco-genetic individual-based models to generate ‘predictive’ values of genetic differentiation. We also used RAD-Seq to genotype 960 yellow perch (Perca flavescens), a species with an ∼30-day pelagic larval duration (PLD), collected from 20 sites circumscribing Lake Michigan. By comparing predictive and empirical values of genetic differentiation, we estimated the relative contributions for known drivers of population connectivity (e.g., currents, behavior, PLD). For the main basin populations (i.e., the largest contiguous portion of the lake), we found that high gene flow led to low overall levels of genetic differentiation among populations (FST= 0.003). By far the best predictors of genetic differentiation were connectivity matrices that1.came from a specific week and year, and2.resulted in high population connectivity. Thus, these narrow windows of time during which highly dispersive currents occur are driving the patterns of population connectivity in this system. We also found that populations from the northern and southern main basin are slightly divergent from one another, while those from Green Bay and the main basin are highly divergent (FST= 0.11). By integrating biophysical and eco-genetic models with genome-wide data, we illustrate that the drivers of population connectivity can be identified in high gene flow systems.
Identification of putative GATA3 regulatory elements and comparison of GATA3 distribution in cochleae of mice, rats, macaques, and humans
Authors: Ghosh Sumana , Wineski Robert , Lopez Ivan A. , Ishiyama Akira , Thapa Punam , Walters Bradley J. 
Published: October 2022

ABSTRACTThe transcription factor GATA3 plays a critical role in the development of neurons and sensory epithelia of the inner ear. In mouse cochleae, GATA3 is downregulated in certain supporting cells (SCs) and in type I spiral ganglion neurons (SGNs) after development. This reduction of GATA3 in SCs severely limitsAtoh1-induced hair cell (HC) regeneration and suggests that a similar downregulation in human cochleae may be limiting for regenerative therapies. However, it is unknown whether GATA3 is similarly or differentially regulated in primates versus rodents. Using CAGE-seq data, we compared over 40 putativeGATA3regulatory elements across species and found both conserved and non-conserved sequences. To assess whether cochlear GATA3 distribution is similar or different between rodents and primates, we immunostained cochleae from mice, rats, macaques, and humans using antibodies raised against highly conserved GATA3 peptide sequences. GATA3 immunostaining in the organs of Corti from all four species revealed a large degree of conservation, where SCs medial and lateral to cochlear HCs exhibited robust nuclear GATA3 immunolabeling, but pillar and Deiters cells had significantly reduced GATA3 immunoreactivity. In all four species, GATA3 was expressed in a subset of SGNs that largely co-expressed peripherin suggesting they were type II SGNs. Only one difference emerged, wherein human cochlear inner hair cells were not GATA3 immunoreactive despite being so in the other species. Overall, the pattern of GATA3 expression in primates appears similar to rodents and reinforces the notion that ATOH1 mediated regenerative therapies may be limited by reduced GATA3 expression in adult SCs.
The CRL4B E3 ligase regulates mitosis by recruiting phospho-specific DCAFs
Authors: Stier Anna , Gilberto Samuel , Mohamed Weaam I. , Helenius Jonne , Mikicic Ivan , Sajic Tatjana , Beli Petra , Müller Daniel J. , Peter Matthias 
Published: October 2022

AbstractThe cullin-4 paralogs CUL4A and CUL4B assemble E3 ubiquitin ligase complexes regulating multiple chromatin-associated cellular functions. Although they are structurally similar, we found that the unique N-terminal extension of CUL4B is heavily phosphorylated during mitosis, and the phosphorylation pattern is perturbed in the CUL4B-P50L mutation causing X-linked intellectual disability (XLID). Phenotypic characterization and mutational analysis revealed that CUL4B phosphorylation is required for efficient progression through mitosis, controlling spindle positioning and cortical tension. Interestingly, while CUL4B phosphorylation triggers chromatin exclusion, it critically promotes binding to actin regulators and two previously unrecognized, CUL4B-specific DCAFs, LIS1 and WDR1. Indeed, co-immunoprecipitation experiments and biochemical analysis revealed that LIS1 and WDR1 interact with DDB1, but their binding requires the phosphorylated N-terminal domain of CUL4B. Together, our study uncovers previously unrecognized DCAFs relevant for mitosis and brain development that specifically bind CUL4B, but not the CUL4B-P50L patient mutant, by a phosphorylation-dependent mechanism.
Morning Star BrandCom: combating Covid-19 vaccine hesitancy
Authors: Dwivedi Vineeta , Krishna Malay , Arora Sunny Vijay 
Published: October 2022

Learning outcomes
This case is intended to help students of business communication and public relations to trace the effects of communication by public figures and understand essential elements of designing effective communication. After working through the case and assignment questions, the students will be able to:understand the drivers of vaccine hesitancy;analyze the effects of mass communication on public sentiment, in a fast-changing public health situation; anddesign interventions to influence public awareness and action, using a simple model (5W) for mass communication.

Case overview/synopsis
As the vaccines first arrived after the devastating first wave of the Covid-19 pandemic, Indians hesitated to take the shot. Vaccine hesitancy, a worldwide phenomenon, hampered the uptake of the first Covid vaccines despite the dark clouds of the lethal disease. The case looks at the massive problem of vaccine hesitancy and how an integrated communication strategy could overcome and mitigate the challenge. The case protagonist, the leader of a communications agency, looks at the messaging, medium and platforms needed for strategic communication pitch to combat this vaccine hesitancy.

Complexity academic level
The case was designed for use in a graduate-level course in business communication. This case may be positioned toward the middle or end of the course to illustrate mass communication strategy for pressing and sensitive challenges. The case may also be used in a course on public relations, both at graduate and undergraduate levels.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 8: Marketing.
Vakrangee: changing lives in rural India
Authors: Mehta Ritu , Mathur Mahima 
Published: October 2022

Learning outcomes
The learning outcomes are as follows: to design an appropriate strategy for firms to succeed in low-income, price-sensitive markets; to appreciate how business model innovation can help to overcome the obstacles faced by firms when serving rural and semi-urban markets in an emerging economy; to identify possible threats to the business model and evaluate strategies to sustain growth in a dynamic environment; and to allow students to consider sources for competitive advantage and how to build a sustainable business model in low-income markets.

Case overview/synopsis
The case details the growth story of Vakrangee Limited (Vakrangee) from a technology consultancy firm to a technology-driven firm focused on creating the largest last-mile retail network providing various services in underserved parts of India, mainly rural India. The firm launched retail outlets called Vakrangee Kendras (VKs) in 2011 that evolved from non-exclusive stores offering a single line of e-governance services into technology-enabled franchisee-based exclusive stores that offered a multiple line of services such as banking, finance, insurance, ATM, e-commerce and logistics. VK however is witnessing competition from different players in different segments. Additionally, the dynamic business environment such as the growing penetration of smartphones and internet usage, heterogeneous needs of customers and government policies pose further threat to the company’s growth in the future. In the wake of these challenges, what should Vakrangee do to sustain its growth? Should it focus on cost-leadership or differentiation for strategic positioning?

Complexity academic level
This case can be used in an MBA or an executive management program, in courses on strategic management, entrepreneurship, services marketing and rural marketing.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 3: Entrepreneurship.
The technological intervention in e-health management: evidence from Thailand
Authors: Raza Mohsin , Khalid Rimsha , Wisetsri Worakamol , Cavaliere Luigi Pio Leonardo , Alnawafleh Hamza Subhi Mohammad , Guzman-Avalos Magna 
Published: October 2022

Purpose
The e-health services came up as an effective tool to mitigate effects of COVID-19 and following social distance norms. This study highlighted an issue of contentious usage intentions of e-health services among Thai older citizens. This study aims to examine the relationship of social influence (SI), information quality (IQ) and the digital literacy (DL) to contentious usage intentions.

Design/methodology/approach
This study follows quantitative techniques, and the sample size is 140 to analyze, that is collected from the older Thai citizens. The convenient sampling technique was used to collect the data and the items were measured by using a five-point Likert scale.

Findings
The findings of this study are having mixed results. The effect of DL and satisfaction (SAT) on continuous usage intention (CUI) is significant. The effect of IQ and SI on CUI is non-significant. The effect of IQ and SI on SAT is significant. Further, the mediating effect of SAT between IQ and CUI is non-significant. However, the mediating effect of SAT between SI and CUI is significant.

Originality/value
This study contributes to knowledge by empirical testing of DL and usage of the medicine. Furthermore, to the best of the authors’ knowledge, this study is one of the rare studies that incorporate technological intervention for drug usage intentions.
Relational resources for innovation ambidexterity within coopetitive relationships: the contingent role of managerial ambidexterity
Authors: Seepana Chandrasekararao , Paulraj Antony , Smart Palie 
Published: October 2022

PurposeWhile the performance benefits of relational resources and managerial ambidexterity have been widely discussed in coopetition literature, there is only limited evidence that illustrates the underlying relationships between these relational resources and managerial ambidexterity. Against this background, this paper aims to investigate how managerial ambidexterity moderates the innovation ambidexterity effects of relational resources (i.e. reciprocal investments and complementary resources).Design/methodology/approachThis study forwards various hypotheses that are grounded within the theoretical tenets of the relational view and the dynamic capabilities perspective. To test the hypotheses, this study uses survey data provided by 313 firms that pursue horizontal coopetition relationships.FindingsThe research findings offer important insights in that while reciprocal investments lead to innovation ambidexterity, complementary resources do not result in such benefits. Additionally, managerial ambidexterity complements the relational resources to develop innovation ambidexterity if and only if both managerial exploration and exploitation are applied simultaneously.Originality/valueAs opposed to widely-held beliefs, this study finds that firms' use of complementary resources is not likely to lead to innovation ambidexterity even though such resources can help in developing strong relationships. In addition, although often overlooked, managerial ambidexterity plays a vital role in transforming relational resources into useful innovations for firms involved in coopetition relationships. It is crucial for firms that their managers balance their ambidextrous activities of exploration and exploitation so as to develop innovation ambidexterity.
A tripartite approach to social inclusion in selected slums in Lagos State, Nigeria
Authors: Popogbe Oluwaseyi Omowunmi , Akinleye Simeon Oludiran , Oke David Mautin 
Published: October 2022

PurposeThis study aims to examine the social inclusiveness of slum dwellers by focusing on three key institutions which are social relations, government and the labour market. The literature emphasises the activities of these three institutions as indicators of social inclusion. Also, they accurately describe the social interactions of slum inhabitants at different levels.Design/methodology/approachThree large slums (Makoko, Ilaje and Iwaya) in Lagos State were purposively selected for this study. Using a multi-stage sampling technique, there was the first level of cluster sampling across the communities and second-level random sampling of household heads in the clusters. In all, 400 respondents were sampled but 388 valid responses were used for the analysis.FindingsThe study found minimal levels of inclusion in many of the indicators. However, Makoko had a higher degree of inclusion with respect to social relations and political participation compared to the other locations. Due to the poor level of governance, the resilience of slum dwellers has waned.Research limitations/implicationsThe study was limited to three of the largest slums in Lagos State. Moreover, due to threats of eviction in recent times, many respondents were reluctant to provide adequate answers to some of the questions asked. However, the responses gotten were adequate to provide appropriate awareness and relevant recommendations.Originality/valueThe use of primary data made it possible for novel results to be generated on social inclusiveness in selected slums. The study extends the frontier of knowledge on social inclusion.