bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic significance of IKZF1 deletions and IKZF1plus profile in children with B‐cell precursor acute lymphoblastic leukemia treated according to the ALL‐IC BFM 2009 protocol
Authors: Braun Marcin , Pastorczak Agata , Sędek Łukasz , Taha Joanna , Madzio Joanna , Jatczak‐Pawlik Izabela , Wypyszczak Kamila , Matysiak Michał , Derwich Katarzyna , Lejman Monika , Kazanowska Bernarda , Szczepański Tomasz , Kowalczyk Jerzy R. , Mlynarski Wojciech ,   the Polish Pediatric Leukemia/Lymphoma Study Group
Published: February 2022

AbstractThe strongest predictors of outcome in pediatric B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) are minimal residual disease (MRD) and specific molecular abnormalities. One unfavorable prognostic factor is the presence of IKZF1 gene aberrations, particularly when co‐occurring with high MRD level at the end of induction treatment. The present study determines the predictive value of a recently‐defined IKZF1‐plus (IKZF1plus) microdeletion profile in 373 children with BCP‐ALL treated according to the ALL‐intercontinental Berlin‐Frankfurt‐Munster protocol 2009 protocol. IKZF1‐wild type (IKZF1wt) patients demonstrated lower leukemic burden parameters than those carrying IKZF1 deletion (IKZF1del [n = 26, 7.0%]) or IKZF1plus pattern (n = 34, 9.1%): (i) median blast percentage at diagnosis (78.0% vs. 86.9% vs. 86.0%; p = 0.021); (ii) median MRD level at day 15 of induction protocol (0.3% vs. 2.1% vs. 0.8%; p = 0.011); (iii) poor steroid response (7.6% vs. 26.5% vs. 12.5%; p = 0.010). Minimal residual disease level at day 33 (MRD33) exceeding 10−4 was more frequently observed in both the IKZF1del and IKZF1plus subgroups than in IKZF1wt patients (n = 9 [36.0%] vs. n = 13 [41.9%] vs. n = 70 [24.0%], p = 0.051). IKZF1plus individuals showed a tendency for a lower MRD reduction between day 15 and 33 compared to IKZF1del patients (p = 0.124). IKZF1del and IKZF1plus patients showed decreased relapse‐free survival (HR [95%CI] for IKZF1wt as reference = 2.72 [1.21–6.11] and 2.00 [0.87–4.49], respectively, p = 0.023). Both genetic markers including IKZF1del and IKZF1plus microdeletion profile provide additional predictive value of treatment outcome in childhood BCP‐ALL and may contribute to more efficient patient stratification; the same is true in MRD guided protocols, which are based on flow cytometric measurements on day 15 of induction protocol.
Likeability and perceived effectiveness of messages designed to encourage physical activity participation among older adults
Authors: Jongenelis Michelle I. , Jackson Ben , Newton Robert U. , Pettigrew Simone 
Published: February 2022

AbstractIssue addressedOlder adults are significantly less likely than their younger counterparts to engage in physical activity. Comprehensive policies to support healthy ageing thus need to include components encouraging greater participation in physical activity in later life. This study tested potential messages for use in health communication campaigns aimed at increasing physical activity among older adults.MethodsTwelve written messages designed to encourage older adults to increase their levels of physical activity were rated by Australians aged 60‐92 years (n = 369; 54% female) on the variables of likeability and perceived effectiveness.ResultsRatings for all the tested messages were high across both outcome variables. The message Move more, live longer scored most favourably, with large majorities of participants liking this message (87%) and considering it effective (81%). Messages featuring rhyming or alliteration were rated significantly higher on both outcomes than messages without these attributes (all Ps < .001).ConclusionsResults provide insights into the types of messages that are likely to be accepted by older adults. Statements that use the phonological patterns of rhyming or alliteration are likely to be especially well received.So What?Increasing participation in physical activity among older adults is critical to promoting the sustainability of health care systems and enhancing quality of life. The specific messaging attributes identified in the present study as being effective could be used by public health practitioners to inform their approach to physical activity messaging to older adults and incorporated into future health communication campaigns to increase their potential effectiveness with this target group.
Comparative analysis of 15 major reference evapotranspiration models based on weighing lysimeter measurements for two different grass species grown in three soil textures
Authors: Ahmadifar Vahdat , Delirhasannia Reza , Sadraddini Ali Ashraf 
Published: February 2022

AbstractIn this study, 15 models in the combination, radiation, and temperature‐based groups were evaluated for three consecutive years (2017–2019) with lysimetric measurements in a semi‐arid region of Iran. To investigate the effects of reference plant species and soil textures on the amounts of reference evapotranspiration (ET0), two grass species including Festuca arundianacea Schreb. and Lolium perenne in the three soil textures sandy loam, clay, and silt loam were planted in the weighing lysimeters. ET0 was affected by soil texture and grass species (p < .01). The highest amount of ET0 occurred in the clay soil and Festuca grass. Comparison of the models' results with Lolium grass lysimetric data showed that the minimum and maximum root mean square error (RMSE) values 1.27 and 3.5 mm d−1 were obtained for the Kimberly‐Penman‐1996 (KP) and DeBruin‐Keijman (DK) models, respectively. Regarding the Festuca grass lysimetric data, the minimum RMSE (1.36 mm d−1) was obtained for the KP and the maximum RMSE (3.6 mm d−1) for the DK model. Group comparison of models showed that the combination models performed better than the other groups' models. The estimated ET0 values by the models had a better match with the measured data of Lolium grass than those of the Festuca grass.
Determined Ag+ and Hg2+ by ethylenediamine perovskite or ethylenediamine perovskite/graphene oxide composite modified glassy carbon electrodes
Authors: Lei Longwen , Pan Yuxin , Dong Yanjie 
Published: February 2022

AbstractAn ethylenediamine perovskite material C2H4(NH3)2Pb2Br6NCs was designed and synthesized, and C2H4(NH3)2Pb2Br6NCs and C2H4(NH3)2Pb2Br6NCs/graphene oxide composite materials were used to modify glassy carbon electrodes. The cyclic voltammetry was used to determine metal ions; the results have shown good sensitivity and selectivity to Ag+ and Hg2+. In this paper, the optimizing experimental conditions are determined by investigating various control factors. This method was used to the determination of Ag+ concentration in wastewater samples from Tongling Nonferrous Metals Factory and Hg2+ concentration in water from Anqing Shitang Lake with a high recovery rate. The results are consistent with the results of inductively coupled plasma emission spectrometer measurement.
Pediatric and Adult Placebo Response Rates in Placebo‐Controlled Clinical Trials Submitted to the US Food and Drug Administration 2012–2020
Authors: Park Kyunghun , Tran Ngan K. , Momper Jeremiah D. , Green Dionna J. , Burckart Gilbert J. 
Published: February 2022

AbstractThe use of placebo concurrent control (placebo‐controlled) is the most rigorous method of evaluating the safety and efficacy of investigational treatments. However, the use of a placebo group in pediatric product development can be challenging due to ethical considerations and potential differences in placebo response rates between adults and children. This study reports the US Food and Drug Administration's experience with placebo response rates in the pediatric population. Products studied under the Best Pharmaceuticals for Children Act and the Pediatric Research Equity Act between 2012 and 2020 were screened. Study characteristics including study type, primary efficacy endpoint(s), placebo response rates for the primary efficacy endpoint(s) and studied age range were collected. A total of 71 drug products used a placebo‐controlled trial. Of these, thirteen products had an identical study design and trial characteristics including the primary efficacy endpoints between pediatric and adult studies. Fifteen products were studied in trials with identical study design but only different primary efficacy endpoints in pediatric and adult populations. Ten products had combined adolescent and adult trials with separate pediatric trials in younger age groups. In each of these cases, the pediatric placebo response was greater, for some trials, and less, for other trials, than the adult placebo response. The pediatric placebo response can vary within an age group for a drug product. Future studies should examine the factors leading to a similarity or dissimilarity in placebo response between pediatric patients and adults.
Family Input for Quality and Safety (FIQS): Using mobile technology for in‐hospital reporting from families and patients
Authors: Bardach Naomi S. , Stotts Jim R. , Fiore Darren M. , Sarkar Urmimala , Sharma Anjana E. , Boscardin W. John , Avina Lizette , Peralta‐Neel Caroline , Rosenbluth Glenn 
Published: February 2022

AbstractObjectiveDespite three decades of effort, ensuring inpatient safety remains elusive. Patients and family members are a potential source of safety observations, but systems gathering these are limited. Our goal was to test a system to gather safety observations from hospitalized patients and their family members via a real‐time mobile health tool.MethodsWe developed a mobile‐responsive website for reporting safety observations. We piloted the tool during June 2017–April 2018 on the medical–surgical unit of a children's hospital. Participants were English‐speaking family members and patients ≥13 years. We sent a daily text with a website link. We assessed: (1) face validity by comparing observations to incident reporting (IR) criteria and to hospital IRs and (2) associations between the number of safety observations/100 patient‐days and participant characteristics using Poisson regression.ResultsWe enrolled 235 patients (43.8% of 537 reviewed for eligibility), resulting in 8.15 safety reports/100 patient‐days, most frequently regarding medications (29% of reports) and communication (20% of reports). Fifty‐one (40% of 125) met IR criteria; only one (1.1%) had been reported via the IR system. Latinx participants submitted fewer observations than White participants (3.9 vs. 10.1, p = .002); participants with more prior hospitalizations submitted more observations (p < .001). In adjusted analyses, including measures of preference in decision making, and patient activation, the difference between Latinx and White participants diminished substantially (6.4 vs. 11.3, p = .16).ConclusionsWe demonstrated the feasibility of real‐time patient and family‐member technology‐enabled safety observation reporting and elicited reports not otherwise identified. Variation in reporting may potentially exacerbate disparities in safety if not addressed.
Collagenic architecture and morphotraits in a marine basal metazoan as a model for bioinspired applied research
Authors: Manconi Renata , Cubeddu Tiziana , Pronzato Roberto , Sanna Marina A. , Nieddu Gabriele , Gaino Elda , Stocchino Giacinta A. 
Published: February 2022

AbstractIn some Porifera (Demospongiae: Keratosa), prototypes of the connective system are almost exclusively based on collagenic networks. We studied the topographic distribution, spatial layout, microtraits, and/or morphogenesis of these collagenic structures in Ircinia retidermata (Dictyoceratida: Irciniidae). Analyses were carried out on a clonal strain from sustainable experimental mariculture by using light and scanning electron microscopy. Histology revealed new insights on the widely diversified and complex hierarchical assemblage of collagenic structures. Key evolutionary novelties in the organization of sponge connective system were found out. The aquiferous canals are shaped as corrugate‐like pipelines conferring plasticity to the water circulation system. Compact clusters of elongated cells are putatively involved in a nutrient transferring system. Knob‐ended filaments are characterized by a banding pattern and micro‐components. Ectosome and outer endosome districts are the active fibrogenetic areas, where exogenous material constitutes an axial condensation nucleus for the ensuing morphogenesis. The new data can be useful to understand not only the evolutionary novelties occurring in the target taxon but also the morpho‐functional significance of its adaptive collagenic anatomical traits. In addition, data may give insights on both marine collagen sustainable applied researches along with evolutionary and phylogenetic analyses, thus highlighting sponges as a key renewable source for inspired biomaterials. Therefore, we also promote bioresources sustainable exploitation with the aim to provide new donors of marine collagen, thereby supporting conservation of wild populations/species.
Storage duration and conditions change the phytate content and phytase activity of wheat grains
Authors: Schollenberger Margit , Sommerfeld Vera , Hartung Jens , Rodehutscord Markus 
Published: February 2022

AbstractBackgroundThe degree to which storage conditions and duration affect phytase activity and inositol phosphates (InsP) was evaluated in wheat. Three wheat cultivars were stored as whole or ground kernels at 20, 7, and −18°C for 13, 48, 118, 188, 265, and 349 days. Samples were analyzed for InsP3‐6 concentration and phytase activity.ResultsThe InsP6 concentration of whole wheat kernels stored at −18 and 7°C did not differ from that at time point 0. Storage of whole kernels at 20°C significantly reduced the InsP6 concentration at days 48, 188, 265, and 349, by up to 8.4%. The InsP6 concentration of ground wheat samples was reduced by up to 23.6% until day 349. The lower InsP isomers Ins(1,2,3,4,5)P5 and Ins(1,2,4,5,6)P5 were detected only at a storage temperature of 20°C and at day 118 or later. Phytase activity did not change over time in ground kernels stored at −18 and +7°C but was decreased in ground kernels at 20°C and in whole kernels independent of temperature. Probable cultivar effects were found regarding phytase activity over time, dependent on grinding and storage temperature.ConclusionTo avoid loss of InsP6 content, wheat samples should be stored as whole kernels at or below 7°C. Phytase activity is more stable in ground samples than in whole kernels. However, some cultivars likely are more prone than others to storage effects.
Perceptions of attractions, residents as “more knowledgeable others” and destination image: Evidence from two destinations
Authors: Stylidis Dimitrios , Woosnam Kyle Maurice , Kim Seongseop ( Sam) 
Published: February 2022

AbstractDrawing on work on the “more knowledgeable other” (MKO) and the mere exposure theory (MET), this study envisaged that visitors' engagement and interaction with key informants, along with their perceptions of the attractions visited, affect their image of and satisfaction with the destination. Findings drawn from two studies indicate that interaction with MKOs and perceptions of attractions determine cognitive, affective, and conative image along with overall satisfaction. Events held in local attractions that promote visitors' interaction with MKOs are proposed for tourists to gain better insights to the place and its locals.
Surgery and Adjuvant Therapy Improve Derkay Scores in Adult and Pediatric Respiratory Papillomatosis
Authors: Hock Kiefer , Kennedy Aimee , Howell Rebecca , Friedman Aaron , de Alarcon Alessandro , Khosla Sid 
Published: February 2022

Objectives/HypothesisComparing Derkay anatomical score at time of procedure, disease characteristics, and mean treatment interval among adult and pediatric patients with recurrent respiratory papillomatosis (RRP).Study DesignRestrospective study.MethodsRetrospective review of juvenile‐onset (JO) and adult‐onset (AO) RRP patients treated longitudinally at pediatric and adult institutions from 1999 to 2019. Patients were included if they had a tissue diagnosis of papilloma and had at least a 12‐month follow‐up.ResultsOne hundred and twelve patients met inclusion criteria (68 JO‐RRP and 44 AO‐RRP). All patients were stratified into either potassium titanyl phosphate (KTP) (n = 42), CO2 (n = 21), or microdebrider (n = 49) treatment groups. The Derkay score improved between first and last procedure in the KTP group (mean difference, 3.5; P < .001), CO2 group (mean difference, 4.4; P < .001), and microdebrider group (mean difference, 4.1; P < .001), but overall improvement did not differ across groups (P = .73). Baseline mean to last mean Derkay score improved for nine patients during bevacizumab treatments (mean difference, 3.0; P = .01) but did not improve for these same patients during an interval prior to receiving bevacizumab treatments. Baseline mean to last mean Derkay score improved for 19 patients during cidofovir treatments (mean difference, 3.84; P < .001) but did not improve for these same patients during the interval prior to receiving cidofovir treatments. The AO‐RRP population had more patients with dysplasia (50%) compared to JO‐RRP population (10%) (P < .001).ConclusionVarious surgical modalities appear to be equally effective treatments for RRP. Adult and pediatric patients have decreased recurrent disease burden when receiving bevacizumab or cidofovir. AO‐RRP patients have more concomitant dysplasia.Level of Evidence3 Laryngoscope, 132:2420–2426, 2022
Laser‐Triggered Interfacial Generation of ROS Promotes a Rapid Fabrication of Polydopamine Coating
Authors: Fang Yu , Wang Jing , Zou Ling‐Yun , Qian Hong‐Lin , Ren Ke‐Feng , Wang You‐Xiang , Ji Jian 
Published: February 2022

AbstractMussel‐inspired polydopamine (PDA) coating has been proved to be a universal surface modification strategy with remarkable versatility and active post‐modification ability. However, the traditional preparation of PDA coating shows low polymerization efficiency and alkaline environment dependency. Herein, a robust method to accelerate the in situ generation of PDA coating based on a photosensitizer entrapped substrate is reported. It is demonstrated that the chlorin e6 (Ce6)‐incorporated substrates induce sustained reactive oxygen species (ROS) production via laser irradiation at 660 nm, which dramatically promotes the preparation of PDA coating even in acidic conditions. The thickness of the PDA coating reaches over 4 nm with only 10 min irradiation (pH 6). Patterned PDA coatings can also be achieved by using a photomask. The functionality of this interfacial ROS‐induced PDA coating including photothermal ability and secondary modification ability is also verified. The obtained PDA coating realizes the reduction of Ag+ to Ag NPs, which shows excellent antibacterial ability. This interfacial ROS generation strategy offers a facile and efficient way to construct the PDA coating and expands the potential applications in the biomedical field.
Comprehensive variant calling from whole‐genome sequencing identifies a complex inversion that disrupts ZFPM2 in familial congenital diaphragmatic hernia
Authors: Nicholas Thomas J. , Al‐Sweel Najla , Farrell Andrew , Mao Rong , Bayrak‐Toydemir Pinar , Miller Christine E. , Bentley Dawn , Palmquist Rachel , Moore Barry , Hernandez Edgar J. , Cormier Michael J. , Fredrickson Eric , Noble Katherine , Rynearson Shawn , Holt Carson , Karren Mary Anne , Bonkowsky Joshua L. , Tristani‐Firouzi Martin , Yandell Mark , Marth Gabor , Quinlan Aaron R. , Brunelli Luca , Toydemir Reha M. , Shayota Brian J. , Carey John C. , Boyden Steven E. , Malone Jenkins Sabrina 
Published: February 2022

AbstractBackgroundGenetic disorders contribute to significant morbidity and mortality in critically ill newborns. Despite advances in genome sequencing technologies, a majority of neonatal cases remain unsolved. Complex structural variants (SVs) often elude conventional genome sequencing variant calling pipelines and will explain a portion of these unsolved cases.MethodsAs part of the Utah NeoSeq project, we used a research‐based, rapid whole‐genome sequencing (WGS) protocol to investigate the genomic etiology for a newborn with a left‐sided congenital diaphragmatic hernia (CDH) and cardiac malformations, whose mother also had a history of CDH and atrial septal defect.ResultsUsing both a novel, alignment‐free and traditional alignment‐based variant callers, we identified a maternally inherited complex SV on chromosome 8, consisting of an inversion flanked by deletions. This complex inversion, further confirmed using orthogonal molecular techniques, disrupts the ZFPM2 gene, which is associated with both CDH and various congenital heart defects.ConclusionsOur results demonstrate that complex structural events, which often are unidentifiable or not reported by clinically validated testing procedures, can be discovered and accurately characterized with conventional, short‐read sequencing and underscore the utility of WGS as a first‐line diagnostic tool.
A high‐performance empty substrate integrated waveguide filter with mixed electric and magnetic coupling
Authors: Qiang Jingxia , Xu Feng , Yang Ling , Liu Shui , Zhan Junlin , Li Min 
Published: February 2022

AbstractAn empty substrate integrated waveguide (ESIW) bandpass filter with enhanced electric and magnetic coupling is proposed in this letter. ESIW uses the air as dielectric in order to reduce the dielectric loss caused by usual medium materials. However, the existence of air cavities requires at least three layers of structure, which greatly increases the difficulty of designing complex circuits with high‐performance and multiple requirements. The proposed mixed coupling structure creates the finite transmission zeros based on ESIW technology for the first time, which makes it possible to realize complex high‐performance circuits with ESIW technology. Taking advantage of the multilayer structure of the ESIW, the proposed cross‐coupling is conveniently realized with higher frequency selectivity and lower insertion loss while maintaining the substrate of three layers and the self‐encapsulation characteristics of ESIW. A fourth‐order filter with an H‐shaped slot line on the top metal plane of two adjacent air cavities is produced. A good agreement between the measurements and simulations indicates that the proposed filter achieves an insertion loss as low as 0.7 dB and the 6.1% bandwidth at 9.85‐GHz X band. It demonstrates the improvement of insertion loss and frequency selectivity, which lays a foundation for the design of complex microwave devices.