bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis of disruptive mood dysregulation disorder in offsprings of bipolar parents
Authors: Sabri Youmna 
Published: March 2022

Abstract
Background
Disruptive mood dysregulation disorder (DMDD) was introduced in (DSM-5) as a new diagnostic category to get control on the exaggerated diagnosis of bipolar disorder in children and adolescents which was elevated more than 40 times in the last decade. Few studies were done recently to explore the role of family history of bipolar disorder in the occurrence of DMDD in children and adolescents. Unfortunately, there is limited number of studies about the familial transmission of DMDD.
The aim of this study is to examine the presence of a relation between DMDD and the presence of a family history of bipolar disorder through comparing the diagnosis of DMDD in offspring of parents with (a) bipolar disorder and (b) a control group.

Results
The distribution of psychiatric disorders among the studied groups highlighted that DMDD and depressive disorder are significantly present in the offsprings of bipolar parents more than in the offsprings of control parents. DMDD is significantly present among offsprings of bipolar parents aged ≤ 11 years old (p = 0.008*). Also, DMDD is significantly (p = 0.02) present among male offsprings of bipolar parents. Also, depressive disorder is significantly (p = 0.002) present among female offsprings of control parents. While significant comorbidity between DMDD and depressive disorders (p = 0.018*) was detected.

Conclusions
This study revealed that DMDD and depressive disorders are significantly present in the offsprings of bipolar parents higher than in the offsprings of control parents. DMDD is significantly present among the offsprings of bipolar parents aged ≤ 11 years old.
The relation between sex and affective disorders among the offsprings was also assessed revealing that DMDD is significantly present among male offsprings of bipolar parents. Also, depressive disorders are significantly present among female offsprings of control parents.
Potential implications
This study has several clinical implications. This study draws attention to the importance of the careful assessment of the offsprings of bipolar patients to check the presence of different childhood psychiatric disorders such as DMDD. Also, symptoms of temper outbursts and persistent irritability in childhood require the necessary of psychiatric evaluation not only for the patients but also for their families. In addition, this study highlights the need for accurate updated diagnostic instruments to differentiate between these overlapping symptoms.
As regards implications for future research, following-up of children diagnosed with DMDD to recognize the prognostic outcome of this new diagnostic category is necessary.
Assessment of variceal bleeding in cirrhotic patients: accuracy of multi-detector computed tomography
Authors: Samy Marwa , Gamal Doaa , Othman Mostafa H. M. , Ahmed Shimaa Abdalla 
Published: March 2022

Abstract
Background
Esophageal variceal hemorrhage (EVH) has been shown to be a leading cause of mortality in patients with portal hypertension. Our purpose was to assess the utility of multi-detector computed tomography (MDCT) features in the assessment of esophageal varices (EVs) and esophageal variceal hemorrhage (EVH). This prospective study included 85 cirrhotic patients who underwent MDCT and Upper Gastrointestinal Tract (UGIT) endoscopy within 2 weeks. Four radiologists evaluated the presence of EVs and the presence and size of different collaterals. Multivariable logistic regression analysis was calculated to investigate the significant predictors influencing EV and EVH.

Results
Findings of EV with MDCT were the best predictor of EV or EVH. The presence (and/or size) of following collaterals had significant association with both EV and EVH: paraesophageal (p < 0.001, < 0.001), short gastric (p = 0.024, 0.010), gastric varicosities (p < 0.001, < 0.001), coronary (p < 0.001, < 0.001), and main coronary vein (MCV) (p < 0.001, = 0.011). We proposed an imaging-based model (presence of coronary collaterals, main coronary vein size > 3.5 mm, presence of short gastric collaterals, presence of gastric varicosities, size > 1.5 mm) with 97% sensitivity, 91% specificity, and 94% accuracy to predict EVs. We suggested another model (presence of paraesophageal collaterals, presence of short gastric vein (SGC), SGC size > 2.5 mm, main coronary vein size > 3.5 mm, gastric varicosities size > 1.5 mm, size of EVs > 4 mm, and Child C score) to predict EVH with 98% sensitivity, 81% specificity, and 89.5% accuracy. Inter-observer agreement was high in the detection of EVs (W. Kappa = 0.71–0.88).

Conclusion
MDCT is an effective modality in the diagnosis of EVs. At MDCT, the presence and/or size of various collaterals including para-esophageal, short gastric, coronary collaterals, and gastric varicosities are accurate predictors for either EVs existence or EVH. We suggested two computed tomography imaging-based models with high reproducibility and acceptable accuracy for the prediction of EV and EVH. With cirrhotic patients, we recommend that radiologists report collaterals in their daily practice.
Investigation into corrosion-induced bond degradation between concrete and steel rebar with acoustic emission and 3D laser scan techniques
Authors: Tang Fujian , Lin Zhibin , Qu Hongya , Chen Genda 
Published: March 2022

AbstractCorrosion-induced bond degradation of deformed steel rebar in concrete is experimentally investigated with acoustic emission (AE) and 3D laser scan technique. Concrete specimens were fabricated and subjected to direct pullout test after being corroded to different levels. The number and width of cracks present during the corrosion tests and the pull-out tests were recorded. The energy released during the pullout tests were captured with AE probes, and the frequency characteristics was analyzed. After pullout tests, the surface morphology of corroded steel rebars was determined with a 3D laser scanner. A modified bond deterioration model was proposed and the parameters associated with the model were analyzed. Results indicated that two types of AE signals were acquired during pullout tests: concrete cracking in high frequency range of 35 ~ 41 kHz and steel-concrete friction in low frequency range of 3 ~ 15 kHz. The bond strength and the bond-slip characteristics depend upon the level of corrosion as well as the number and width of cracks. The reduction factor of the bond-slip model exponentially decreases as a function of the average cross-sectional area loss and linearly decreases with an increase of the rib area loss.
Inherited metabolic disorders in a cohort of Egyptian children
Authors: Abdelsattar Shimaa , Obada Manar , El-Hawy Mahmoud A. , Abd El Naby Sameh A. , Zaki Osama K. , Elsaid Hala 
Published: March 2022

Abstract
Background
Inborn errors of metabolism (IEMs) represent a special challenge in pediatric practice. Despite the unquestionable clinical significance of newborn screening, it just offers a snapshot of an extremely minor subgroup of metabolic disorders. So, it is crucial to use multiple techniques for accurate diagnosis of a wider spectrum of IEMs early in infancy to prevent overwhelming irreversible neurological complications in a cohort of high-risk Egyptian pediatrics. This study included four thousand and eighty suspected IEMs patients. They were referred to the Chromatography Unit, Clinical Biochemistry and Molecular Diagnostics Laboratories, National Liver Institute (NLI) for laboratory assessment in the period from March 2016 to November 2020. Separation of amino acids and acylcarnitines using tandem mass spectrometry (LC/MS) and organic acids using gas chromatography mass spectrometry (GC/MS) was done.

Results
Three hundred and twenty (320/4080, 7.8%) patients were diagnosed with IEMs. The following disorders were identified: organic acidopathies—200 (62.5%) including methylmalonic acidemia (MMA) (48/320, 15%), glutaric academia (GA) (40/320, 12, 5%), propionic acidemia (PA), (32/320, 10%), isovaleric acidemia (IVA) (40/320, 12.5%), methylcrotonyl glyceinuria (16/320, 5%), and orotic acidemia (24/320, 7.5%); amino acidopathies—80 (25%) including maple syrup urine disease (MSUD) (32/320, 10%), phenylketonuria (24/320, 7.5%), homocystinuria (16/320, 5%), and nonketotic hyperglycinemia (8/320, 2.5%) in addition to fatty acid disorders (FAO): 24 (7.5%) and lactic academia (LA), 16 (5%).

Conclusion
Early detection of IEMs by rapid non-invasive techniques. LC/MS and GC/MS. is a crucial process for early diagnosis of different types of IEMs to install therapeutic clue in a group of high-risk Egyptian pediatrics for proper treatment and better outcome
Targeted newborn hearing screening in the neonatal intensive care unit of Assiut University Hospital
Authors: Omar Kholoud Mohamed , Mohamed Enass Sayed , Said Eman Abdel Fattah , AbdelAziz Nafisa H. R. , Aly Maha Abdelgaber A. 
Published: March 2022

Abstract
Background
Early detection of congenital hearing loss (HL) and appropriate intervention is essential to minimize its dramatic impact. Target-based newborn hearing screening (TNHS) was initially targeted high-risk register (HRR) newborn. The advance techniques in neonatology in neonatal intensive care unit (NICU) lead to decrease mortality among low birth weight and preterm infants, but significant morbidities including hearing loss persist. In this study, we aimed to assess the prevalence of hearing loss and the percentage of different risk factors among the HRR neonates admitted to NICU at Assiut University Hospital.

Results
The prevalence of hearing loss among the study group is 1%. The most common risk factor present between the study group was prematurity associated with the low birth weight (57%). The combination of preterm and low birth weight has statistically significant effect on hearing loss (p < 0.006). There was statistically significant difference in the pass rate of the transient evoked otoacoustic emission (TEOAE) frequencies included in the screening program. The highest pass rate 91% and 85% was at 4 KH and 3 KH, respectively, while the least pass rate was at 1 KH (11.5%).

Conclusion
TEOAE screener is safe, noninvasive, and doesn’t require sedation and cost-effective method in the newborn hearing screening at NICU. For HRR, it is better to do screening before hospital discharge so allowing enough time for comorbidities of the neonate to improve. Neonatal hearing screening in high-risk neonates in NICU allows early identification of children with hearing loss with early intervention.
Probabilistic analysis of land subsidence due to pumping by Biot poroelasticity and random field theory
Authors: Deng Sirui , Yang Haoqing , Chen Xiaoying , Wei Xin 
Published: March 2022

AbstractLand subsidence is a global problem in urban areas. The main cause of land subsidence is the pumping of subsurface water. It is of great significance to study the subsurface settlement and water flow of the lands due to pumping. In this study, the probabilistic analysis of land subsidence due to pumping is performed by Biot’s poroelasticity and random field theory based on a case study. The results show that the change of deformation of the aquifer is far less significant than the hydraulic head over the years. When considering the spatial variability of soil strength, the land subsidence suffers from great uncertainty when the correlation length is large. Nevertheless, the spatial variability of soil strength on the uncertainty of hydraulic head can be ignored. When considering the spatial variability of soil hydraulic conductivity, the uncertainty of the hydraulic head is mainly located near the bedrock and increases markedly along with the rise of the correlation length. Time is another important factor to increase the uncertainty of the hydraulic head. However, its contribution to the uncertainty of displacement is insignificant.
The effect of the COVID-19 pandemic on mental health in individuals with pre-existing mental illness
Authors: Lewis Katie J. S. , Lewis Catrin , Roberts Alice , Richards Natalie A. , Evison Claudia , Pearce Holly A. , Lloyd Keith , Meudell Alan , Edwards Bethan M. , Robinson Catherine A. , Poole Rob , John Ann , Bisson Jonathan I. , Jones Ian 
Published: March 2022

BackgroundThere is evidence that the COVID-19 pandemic has negatively affected mental health, but most studies have been conducted in the general population.AimsTo identify factors associated with mental health during the COVID-19 pandemic in individuals with pre-existing mental illness.MethodParticipants (N= 2869, 78% women, ages 18–94 years) from a UK cohort (the National Centre for Mental Health) with a history of mental illness completed a cross-sectional online survey in June to August 2020. Mental health assessments were the GAD-7 (anxiety), PHQ-9 (depression) and WHO-5 (well-being) questionnaires, and a self-report question on whether their mental health had changed during the pandemic. Regressions examined associations between mental health outcomes and hypothesised risk factors. Secondary analyses examined associations between specific mental health diagnoses and mental health.ResultsA total of 60% of participants reported that mental health had worsened during the pandemic. Younger age, difficulty accessing mental health services, low income, income affected by COVID-19, worry about COVID-19, reduced sleep and increased alcohol/drug use were associated with increased depression and anxiety symptoms and reduced well-being. Feeling socially supported by friends/family/services was associated with better mental health and well-being. Participants with a history of anxiety, depression, post-traumatic stress disorder or eating disorder were more likely to report that mental health had worsened during the pandemic than individuals without a history of these diagnoses.ConclusionsWe identified factors associated with worse mental health during the COVID-19 pandemic in individuals with pre-existing mental illness, in addition to specific groups potentially at elevated risk of poor mental health during the pandemic.
Say's Second Visit to Britain: A Career Turning Point
Authors: Alcouffe Alain , Le Bris David 
Published: March 2022

Abstract
Economist turned entrepreneur Say was uncertain about his future in 1814 when he was commissioned by the French government to document British industrial progress at a critical point of the industrial takeoff. This trip offered the opportunity to observe the economic life of a different country and to deepen his knowledge of the economic consequences of parliamentarism or the Corn Laws. He also developed a specific understanding of the changes occurring in Britain stressing economies of scale, the role of coal for steam, and the horrific situation of the working class. As key causes, he identified British naval domination of the seas and, more surprisingly, the general distortion induced by very heavy taxation. Through his travel, Say also imported new views about education that he disseminated in France before turning himself to the teaching of economics, starting, at forty-eight years of age, an academic career.
Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications
Authors: Pacetti Miriam , De Conti Laura , Marasco Luciano E. , Romano Maurizio , Rashid Mohammad M. , Nubiè Martina , Baralle Francisco E. , Baralle Marco 
Published: March 2022

ABSTRACT
The cellular level of TDP-43 (also known as TARDBP) is tightly regulated; increases or decreases in TDP-43 have deleterious effects in cells. The predominant mechanism responsible for the regulation of the level of TDP-43 is an autoregulatory negative feedback loop. In this study, we identified an in vivo cause-effect relationship between Tardbp gene promoter methylation and specific histone modification and the TDP-43 level in tissues of mice at two different ages. Furthermore, epigenetic control was observed in mouse and human cultured cell lines. In amyotrophic lateral sclerosis, the formation of TDP-43-containing brain inclusions removes functional protein from the system. This phenomenon is continuous but compensated by newly synthesized protein. The balance between sequestration and new synthesis might become critical with ageing, if accompanied by an epigenetic modification-regulated decrease in newly synthesized TDP-43. Sequestration by aggregates would then decrease the amount of functional TDP-43 to a level lower than those needed by the cell and thereby trigger the onset of symptoms.
Population attributable risk for colorectal and breast cancer in England, Wales, Scotland, Northern Ireland, and the United Kingdom
Authors: Goon Shatabdi , Kim Hanseul , Giovannucci Edward L. 
Published: March 2022

Background: The population attributable risk (PAR) is a statistic commonly used for quantifying preventability of cancer. We report here PAR estimates for the United Kingdom (UK) along with its constituent countries for up-to-date risk factor-attributable colorectal cancer (CRC) and breast cancer (BC), focusing on diet and nutrition related factors and tobacco (CRC) using representative national surveys. Methods: The PAR was calculated using established, modifiable risk factors by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR): physical activity, body mass index (BMI), alcoholic drinks, red meat, processed meat, dietary fiber, dietary calcium, as well as cigarette smoking for CRC, and physical activity, BMI, alcoholic drinks, and fruits and vegetable consumption for BC. National prevalence estimates and relative risks (RRs) for CRC and BC were obtained from meta-analyses or large pooled analyses. Results: Based on eight dietary and lifestyle risk factors, the estimates for attributable cases of CRC for males and females, respectively, were as follows: England: 67% and 60%; Scotland: 68% and 59%, Wales: 66% and 61%; Northern Ireland: 67% and 61%; and UK: 67% and 60%. Excluding smoking, the PAR for the UK was 61% for men and 52% for women. Based on four dietary and lifestyle risk factors, the estimates for BC were as follows: England: 26%, Scotland: 27%; Wales: 25%; Northern Ireland: 26%; and UK: 27%. Conclusion: Up to 67% for CRC and 27% of BC were attributable to modifiable dietary and lifestyle factors in the UK. Moderate differences in PAR are observed between countries due to different prevalence of exposure to risk factors.
The Man of the Shroud of Turin: Is He Dead or Alive?
Authors: Hontanilla Calatayud Bernardo 
Published: March 2022

It has been assumed that the person represented on the Shroud of Turin is dead and the image corresponds to a person dead from crucifixion. We have conducted an analysis of the cadaveric data of a body and the presence of face life signs and we could think that the image could corresponds to a living person. Therefore, it might correspond to a man starting a getting up gesture. If we examine the Gospels, a remarkable symmetry is found between the data obtained from the image and the events described in the Gospels, regarding the death and resurrection of Jesus.
Rationality and Human Fulfilment Clarified by a Thomistic Metaphysics of Participation
Authors: Mullins Andy 
Published: March 2022

A Thomistic metaphysics of participation in being offers an account of rationality that is more complete and coherent than that of nonreductive physicalism. It is a reasoned understanding of how an embodied intellectual subject shares in being and intellectual life. This metaphysical framework supports an understanding of rationality as a participated power, and an essential property of human nature empowering persons to know reality and make choices accordingly. Human fulfilment in truth and love is a consequence of the grounding of the transcendentals of truth and goodness in being. In contrast, nonreductive physicalism reduces rationality to processes and subjective experiences and can offer no priority between human material and spiritual fulfilment. Although a Thomistic metaphysics of participation in being has been effectively absent from Anglo-American hylomorphic philosophy of mind, this paper suggests it is time to reassess the benefits it offers.
The Rectangular Bin Challenge: Using 3D Simulation to Explore New Bin Filler Methods for Apple Harvest Platforms
Authors: Halali Nadav , Reshef Liad , Salzer Yael 
Published: March 2022

HighlightsBin filler design and bin dimensions determine the apple distribution in the bin.The performance of new apple distribution systems was estimated with 3D simulations.A simulated lemniscate path showed improved apple distribution in rectangular bins.3D simulation provides an efficient tool for design decisions before prototype production.Abstract. Mechanical harvest platforms equipped with conveyors are meant to replace the traditional apple-picking ladders and buckets; however, their feasibility has not yet been exhaustively established. The conveyors transport picked apples to the bin filler, which distributes the fruit into the bins. Commercial harvest platforms are designed to perform well with square bins; however, Israeli apple industry bins are rectangular. This results in non-uniform apple distribution, which requires human intervention and contributes to apple bruising and economic loss. In this study, 3D simulation was used to quantitatively evaluate the performance of three novel bin filler designs (back-and-forth, double disk, and lemniscate) and compare them to commercial bin fillers. The bin filler models were tested for the uniformity of the apple distribution in square and rectangular bins. The angle of repose and the standard deviation of the height of the top layer of apples were calculated. The commercial bin filler model performed better when filling a square bin (angle = 12°, SD height = 31 mm) than a rectangular bin (angle = 18°, SD height = 71 mm). The lemniscate model (angle = 10°, SD height = 41 mm) outperformed the two other novel models as well as the commercial bin filler model (angle = 18°, SD height = 67 mm). A machine design for the lemniscate model is proposed. The quantitative method described in this study illustrates the potential benefit of 3D simulation as an inexpensive means to explore the feasibility of new harvest devices. Keywords: 3D simulation, Apple, Bin filler, Fruit distribution, Harvest, Mechanical platform.
Tunable liquid crystal core refractive index sensor based on surface
plasmon resonance in gold nanofilm coated photonic crystal fiber
Authors: Fan Zhenkai , Chu Shichao , Qin Jianye , Zhang Yinping , Liu Haishan 
Published: March 2022

We propose, to the best of our knowledge, a novel kind of tunable liquid crystal core refractive index (RI) sensor based on photonic crystal fiber (PCF) covered with a nanoring gold film. The finite element method is used to discuss and analyze the sensing performance of the RI sensor. Gold is used as the excitation material for surface plasmon resonance, and a gold nanoring is embedded around the first cladding of the PCF. The liquid analytes penetrate the outermost layer of the cladding, and the central hole is filled with liquid crystal E7. Complete coupling and incomplete coupling are excited as the analyte RI increases, and the resonance strength of complete coupling is stronger than that of incomplete coupling. It can be proved by calculation that at different wavelengths, resonant coupling of fifth-order and sixth-order surface plasmon polaritons is obtained. The RI of liquid analytes ranges from 1.405 to 1.445. The diameters of the liquid crystal cores are 0.2, 0.4, 0.6, and 0.8 µm; their average sensitivities are 10700, 10566, 10167, and 9166 nm/RIU; and the linear fitting constants are 0.98025, 0.97387, 0.96597, and 0.95507, respectively. In short, the RI sensor has the advantages of tunability, wide range, and high sensitivity, and is expected to be applied in various fields.