bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penta-Helix Model of E-Government in Combating Corruption in Indonesia and Malaysia: Religiosity as a Moderating Role
Authors: Purnamasari Pupung , Amran Noor Afza , Nu'man A. Harits , Frendika Rusman , Nor Mohamad Naimi Mohamad , Ismail Mohamad Sharofi 
Published: August 2022

Background: E-government is an initiative taken by governments worldwide to align the administration of their countries. Governments have utilized the internet as part of a transition into a globalized economy. This helps reduce red tape and procedures in dealing with people in government agencies. This study aims to develop an e-government model as an anti-corruption strategy by applying the Penta-helix model and religiosity as the moderating variable. Methods: The data was gathered from government officials, representatives in business, media, academia, and NGOs, in Indonesia and Malaysia in 2021. Online questionnaires were distributed to 240 respondents from Indonesia and Malaysia. In addition, SPSS v.25 and SEM AMOS v.25 were used to analyze the data. Results: The findings indicate that the Penta-helix elements and religiosity could help to reduce corruption in Indonesia. Meanwhile, Malaysia must increase its human resource competency and embed the religiosity element as a tool to reduce corruption. Conclusion: Penta-helix and religious factors should be incorporated by organizations in Malaysia and Indonesia as part of their strategy in combating corruption.
A quantitative analysis of trauma patients having undergone plastic surgery
Authors: Lim Nam Kyu , Yoon Jae Hee 
Published: August 2022

PurposeWhile plastic surgeons have been historically indispensable in reconstruction of posttraumatic defects, their role in Level I trauma centers around the world has not yet been clearly approved. This study aims to assess the contribution of plastic surgeons in major trauma care by evaluating the characteristics of trauma patients underwent plastic surgery at a Level I trauma center.MethodFrom November 2014 to October 2020, we conducted a retrospective review of our hospital’s Trauma Registry System for patients with an Injury Severity Score (ISS) of 9 or higher. Of all of 7174 patients, the plastic surgery (PS) department treated 870 patients; the 6304 patients not treated by the PS were classified as the Non-PS. Then, we performed propensity score matching to reduce the statistical bias, after the death in the emergency room and the missing value were considered exclusion criteria.ResultThe mean ISS showed no significant difference between two groups (16.29 ± 7.04 in the PS vs. 16.68 ± 9.16 in the Non-PS,p= 0.3221). According to investigate the Abbreviated Injury Scale, both head and neck (65.0%) and face (46.4%) categories showed significantly higher in the PS group than the Non-PS group (p< 0.0001), and its contribution ratio was 2.151 and 21.822 times, respectively.ConclusionThis study revealed the specialty of plastic surgery was face area in trauma care. We thus argue that plastic surgical care is imperative for trauma patients, and expect to be implicated in trauma system planning.
Clients satisfaction at primary healthcare facilities and its association with implementation of client service charter in Tanzania
Authors: Kinyenje Erick S. , Yahya Talhiya A. , Degeh Mbwana M. , German Chrisogone C. , Hokororo Joseph C. , Mohamed Mohamed A. , Nassoro Omary A. , Bahegwa Radenta P. , Msigwa Yohanes S. , Ngowi Ruth R. , Marandu Laura E. , Mwaisengela Syabo M. , Eliakimu Eliudi S. 
Published: August 2022

Background
Client service charter (CSC) provides information about what people can expect in a facility’s services; what is expected of clients and service providers. Tanzania implemented Star Rating Assessment (SRA) of primary health care (PHC) facilities in 2015/16 and 2017/18 using SRA tools with 12 service areas. This paper assesses the status of service area 7, namely client focus that checked if client was satisfied with services provided and implementation of CSC through three indicators–if: CSC was displayed; CSC was monitored; client feedback mechanism and complaints handling was in place.

Methods
We extracted and performed a cross-sectional secondary data analysis of data related to clients’ focus that are found in national SRA database of 2017/2018 using STATA version 15. Client satisfaction was regarded as dependent variable while facility characteristics plus three indicators of CSC as independent variables. Multivariate logistic regression with p-value of 5% and 95% confidence interval (CI) were applied.

Results
A total of 4,523 facilities met our inclusion criteria; 3,987 (88.2%) were dispensaries, 408 (9.0%) health centres and 128 (2.8%) hospitals. CSC was displayed in 69.1% facilities, monitored in 32.4% facilities, and 32.5% of the facilities had mechanisms for clients’ feedback and handling complaints. The overall prevalence of clients’ satisfaction was 72.8%. Clients’ satisfaction was strongly associated with all implementation indicators of CSC. Clients from urban-based facilities had 21% increased satisfaction compared rural-based facilities (AOR 1.21; 95%CI: 1.00–1.46); and clients from hospitals had 39% increased satisfaction compared to dispensaries (AOR 1.39; 95%CI: 1.10–1.77).

Conclusion
The implementation of CSC is low among Tanzanian PHC facilities. Clients are more satisfied if received healthcare services from facilities that display the charter, monitor its implementation, have mechanisms to obtain clients feedback and handle complaints. Clients’ satisfaction at PHC could be improved through adoption and implementation of CSC.
Utility of automated data-adaptive propensity score method for confounding by indication in comparative effectiveness study in real world Medicare and registry data
Authors: Kumamaru Hiraku , Jalbert Jessica J. , Nguyen Louis L. , Williams Lauren A. , Miyata Hiroaki , Setoguchi Soko 
Published: August 2022

Background
Confounding by indication is a serious threat to comparative studies using real world data. We assessed the utility of automated data-adaptive analytic approach for confounding adjustment when both claims and clinical registry data are available.

Methods
We used a comparative study example of carotid artery stenting (CAS) vs. carotid endarterectomy (CEA) in 2005–2008 when CAS was only indicated for patients with high surgical risk. We included Medicare beneficiaries linked to the Society for Vascular Surgery’s Vascular Registry >65 years old undergoing CAS/CEA. We compared hazard ratios (HRs) for death while adjusting for confounding by combining various 1) Propensity score (PS) modeling strategies (investigator-specified [IS-PS] vs. automated data-adaptive [ada-PS]); 2) data sources (claims-only, registry-only and claims-plus-registry); and 3) PS adjustment approaches (matching vs. quintiles-adjustment with/without trimming). An HR of 1.0 was used as a benchmark effect estimate based on CREST trial.

Results
The cohort included 1,999 CAS and 3,255 CEA patients (mean age 76). CAS patients were more likely symptomatic and at high surgical risk, and experienced higher mortality (crude HR = 1.82 for CAS vs. CEA). HRs from PS-quintile adjustment without trimming were 1.48 and 1.52 for claims-only IS-PS and ada-PS, 1.51 and 1.42 for registry-only IS-PS and ada-PS, and 1.34 and 1.23 for claims-plus-registry IS-PS and ada-PS, respectively. Estimates from other PS adjustment approaches showed similar patterns.

Conclusions
In a comparative effectiveness study of CAS vs. CEA with strong confounding by indication, ada-PS performed better than IS-PS in general, but both claims and registry data were needed to adequately control for bias.
A pilot cost-benefit analysis of a children’s spectacle reimbursement scheme: Evidence for Including children’s spectacles in Mongolia’s Social Health Insurance
Authors: Yong Ai Chee , Chuluunkhuu Chimgee , Chan Ving Fai , Stephan Tai , Congdon Nathan , O’Neill Ciaran 
Published: August 2022

Background and aim
Globally, 12.8 million children have vision impairment due to uncorrected refractive error (URE). In Mongolia, one in five children needs but do not have access to spectacles. This pilot cost-benefit analysis aims to estimate the net benefits of a children’s spectacles reimbursement scheme in Mongolia.

Methods
A willingness-to-pay (WTP) survey using the contingent valuation method was administered to rural and urban Mongolia respondents. The survey assessed WTP in additional annual taxes for any child with refractive error to be provided government-subsidised spectacles. Net benefits were then calculated based on mean WTP (i.e. benefit) and cost of spectacles.

Results
The survey recruited 50 respondents (mean age 40.2 ± 9.86 years; 78.0% women; 100% response rate) from rural and urban Mongolia. Mean WTP was US$24.00 ± 5.15 (95% CI US$22.55 to 25.35). The average cost of a pair of spectacles in Mongolia is US$15.00. Subtracting the average cost of spectacles from mean WTP yielded a mean positive net benefit of US$9.00.

Conclusion
A spectacle reimbursement scheme is potentially a cost-effective intervention to address childhood vision impairment due to URE in Mongolia. These preliminary findings support the proposal of the inclusion of children’s spectacles into existing Social Health Insurance. A much larger random sample could be employed in future research to increase the precision and generalisability of findings.
Chemically modified Teucrium polium (Lamiaceae) plant act as an effective adsorbent tool for potassium permanganate (KMnO4) in wastewater remediation
Authors: AL-Aoh Hatem A. , Alamrani Nasser A. 
Published: August 2022

Abstract
Powdered Teucrium polium leaves (S1) were modified with zinc chloride (ZnCl2) (S2), a mixture of copper sulfide (CuS) and ZnCl2 (S3), and oxalic acid (H2C2O4) (S4). The porosity, surface area, and functional groups of these four samples, along with their ability to uptake KMnO4 from solutions, were inspected to identify the optimal adsorbent. For KMnO4 adsorption by the ideal adsorbent (S2), the pHZPC (pH value at which the adsorbent surface is uncharged), influences of experimental circumstances, and dynamic, isotherm, and thermodynamic parameters were examined. According to the results, the surface area, pore size, pore volume, and pHZPC of the optimum adsorbent (S2) are 3.689 m2/g, 570.20 Å, 0.01776 cm3/g, and 6.4, respectively. The optimal S2 dose, the ideal value of pH solution, and equilibrium time are 0.05 g, 5.5, and 192 min, respectively. The Langmuir and second-order models are appropriate for modeling this adsorption. Furthermore, increasing the temperature from 27 to 57°C increases the maximum adsorption capacity (q
max) from 833.33 to 1000.00 mg/g. According to the thermodynamic data, this adsorption is both endothermic and spontaneous.
Almost-complex invariants of families of six-dimensional solvmanifolds
Authors: Tardini Nicoletta , Tomassini Adriano 
Published: August 2022

Abstract
We compute almost-complex invariants

h

∂
¯

p
,
o

h_{\bar \partial }^{p,o}

,

h

D
o
l

p
,
o

h_{Dol}^{p,o}

and almost-Hermitian invariants

h

δ
¯

p
,
o

h_{\bar \delta }^{p,o}

on families of almost-Kähler and almost-Hermitian 6-dimensional solvmanifolds. Finally, as a consequence of almost-Kähler identities we provide an obstruction to the existence of a compatible symplectic structure on a given compact almost-complex manifold. Notice that, when (X, J, g, ω) is a compact almost Hermitian manifold of real dimension greater than four, not much is known concerning the numbers

h

∂
¯

p
,
q

h_{\bar \partial }^{p,q}

.
Synthesis of enhanced lipid solubility of indomethacin derivatives for topical formulations
Authors: Abualhasan Murad , Jaradat Nidal , Maslamani Raghad , Nofal Dana , Omar Linda 
Published: August 2022

Abstract
Indomethacin is a nonselective nonsteroidal anti-inflammatory drug with serious side effects such as depression, hallucination, and gastrointestinal irritation. This study aims to enhance indomethacin lipid solubility of indomethacin derivative to use it for the topical formulation since topical formulation may lower the unwanted side effects. The lipid solubility was achieved by adding various alkyl groups (methyl, ethyl, propyl, and isopropyl) to the drug via an ester linkage. The measured log p of these compounds was higher compared to the underivatized indomethacin. Furthermore, an ointment of each ester was formulated and was tested on mice skin using Franz diffusion. The best absorption was observed for methyl indomethacin with threefold increase in permeability compared to indomethacin. This study approves using derivatized indomethacin as a topical formulation with improved efficacy compared to the present gel formulation in the market.
Geopolitical Risk and the LNG-LPG Trade
Authors: Michail Nektarios A. , Melas Konstantinos D. 
Published: August 2022

Abstract
We explore the relationship between Liquified Natural Gas (LNG) and Liquified Petroleum Gas (LPG) carrier freight rates and global geopolitical risk, while also controlling for the macro environment. Our results show that a shock in geopolitical risk significantly increases the cost of the spot charter rates for both LNG and LPG carriers, with the impact reaching around 25% for the former and 18% for the latter. Our results bear significant implications for both the companies and the countries involved in the liquefied gas trade, with its importance growing as the use of this energy source is likely to continue substituting other fossil fuels in the future.
Constricted migration is associated with stable 3D genome structure differences in cancer cells
Authors: Golloshi Rosela , Playter Christopher , Freeman Trevor F , Das Priyojit , Raines Thomas Isaac , Garretson Joshua H , Thurston Delaney , McCord Rachel Patton 
Published: August 2022

AbstractTo spread from a localized tumor, metastatic cancer cells must squeeze through constrictions that cause major nuclear deformations. Since chromosome structure affects nucleus stiffness, gene regulation, and DNA repair, here, we investigate the relationship between 3D genome structure and constricted migration in cancer cells. Using melanoma (A375) cells, we identify phenotypic differences in cells that have undergone multiple rounds of constricted migration. These cells display a stably higher migration efficiency, elongated morphology, and differences in the distribution of Lamin A/C and heterochromatin. Hi‐C experiments reveal differences in chromosome spatial compartmentalization specific to cells that have passed through constrictions and related alterations in expression of genes associated with migration and metastasis. Certain features of the 3D genome structure changes, such as a loss of B compartment interaction strength, are consistently observed after constricted migration in clonal populations of A375 cells and in MDA‐MB‐231 breast cancer cells. Our observations suggest that consistent types of chromosome structure changes are induced or selected by passage through constrictions and that these may epigenetically encode stable differences in gene expression and cellular migration phenotype.
The effect of controlled ovarian hyperstimulation on ovarian reserve via PTEN pathway
Authors: Sezginer Perihan , Elmas Cigdem , Yıldız Fatma 
Published: August 2022

Graphical abstract

Abstract
This study was carried out to investigate whether repeated controlled ovarian hyperstimulation (COH) affects ovarian reserve. For this reason, we aimed to show possible changes in the expression of PTEN and FOXO3, which are involved in preserving the over-reserve, after applying the COH protocol methods. For this purpose, 18 young Wistar albino female rats (8 weeks old) were randomly assigned as group 1 (control), group 2, and group 3 as 6 subjects in each group. Experimental groups were treated with 10 IU/0.1 mL pregnant mare’s serum gonadotropin and a COH protocol consisting of 10 IU/0.1 mL human chorionic gonadotropin injection after 48 h. This procedure was applied three and five times to group 2 and group 3, respectively. For the control groups, the same procedures were performed with 0.1 mL of 0.9% sodium chloride solution. At the end of the experiment, the ovarium tissues were placed in a 10% neutral formaldehyde solution for light microscopic examinations. In histological sections stained with hematoxylin and eosin, the number of ovarian follicles was determined using the physical dissector method. However, the expression of PTEN, FOXO3, and LH-R molecules was evaluated by immunohistochemical methods. As a result of our study, it was concluded that COH administration reduces the expression levels of PTEN and FOXO3 proteins and LH-R, which are among the essential components of the PIK3 intracellular signaling pathway and also increased the levels of hormones such as follicle-stimulating hormone, estradiol, and luteinizing hormone, which are over-reserve markers, and causes adverse effects on the histological structure, oocyte morphology, and number of ovaries.

Lay summary
Today, approximately 10–15% of couples experience fertility problems. However, assisted reproductive techniques help people with fertility problems to get pregnant. The main purpose of these techniques is to put the sperm and egg together outside the woman’s body where the eggs are fertilized and then to return the fertilized eggs (embryos) to the womb. During a woman’s menstrual cycle, several hormones influence the growth of the eggs. This process can be mimicked by using various medications. Medication is given to increase the number of eggs that develop. However, this method is not the same as normal ovulation. Therefore, in our study, we wanted to examine the effect that developing multiple follicles has on the number and quality of eggs remaining for the future.
Structures at Buck Mountain, Nevada: Establishing the Southeastern Extent of Mid-Pennsylvanian Tectonism
Authors: Whitmore Ross J. , Cashman Patricia H. , Sturmer Daniel M. 
Published: August 2022

This paper reports the structural and stratigraphic history of Buck Mountain, Nevada, and its regional significance in the development of southwestern Laurentia during the late Paleozoic. The two distinct generations of folding have similar style and/or timing to other fold sets in late Paleozoic strata of northern Nevada. Unconformities in the upper Paleozoic strata at Buck Mountain are consistent with unconformities documented in northern and east-central Nevada.
Northwest-vergent folds (F1) in the Morrowan–Atokan Ely Limestone are erosionally truncated and unconformably overlain by the middle Desmoinesian Hogan Formation and middle Wolfcampian (Sakmarian) Upper Strathearn Formation. This upper Paleozoic stratigraphic package was subsequently refolded by the Buck Mountain Syncline and associated mesoscale folds (F2). F2 folds lack tight age control but are interpreted to be associated with the Cretaceous central Nevada thrust belt. Critically, none of these structures are localized above or below low-angle faults.
The unconformity between the Ely and Hogan formations is consistent with the C5 regional unconformity. Importantly, it constrains the age of northwest-vergent deformation on Buck Mountain. West-vergent folds and west-directed thrusts are documented at several locations in northern and east-central Nevada, but because of the dominance of the C6 unconformity and/or lack of robust age control, the age of these structures has not been tightly constrained. The evidence at Buck Mountain indicates that west-vergent structures predate the C5 unconformity.
Buck Mountain is important because it: (1) precisely brackets the age of west-vergent deformation in Nevada to pre–mid-Desmoinesian (sub C5-unconformity) and (2) defines a southeastern edge to the late Paleozoic west-vergent deformation in northern and east-central Nevada.
Computational prediction of Carica papaya phytocompounds as potential drug agent against RdRp and spike protein of SARS-nCoV2 by molecular docking and dynamics simulation approaches
Authors: Saif Rashid , Zafar Muhammad Osama , Raza Muhammad Hassan , Zia Saeeda , Qureshi Abdul Rasheed 
Published: August 2022

Abstract
The emergence of the COVID-19 outbreak caused by SARS-nCoV2 led to mass-scale mortalities worldwide. The need of the hour is to develop strategies and design drugs/vaccines to control this contagion. Current research predicted the promising drug agents from the Carica papaya compounds by docking and MD simulations approaches with two major drug target proteins of spike receptor-binding domain and RNA-dependent RNA polymerase of SARS-nCoV2. MOE & PyRx softwares were used for ligand-protein interactions and docking scores predictions. Additionally, MD simulation analysis was performed on the ligands with the lowest binding energies using the NAMD/VMD softwares to compute the stability of the best complexes. Furthermore, SwissADME analysis was also performed to check Lipinski's physiochemical parameters of ligands. Our docking results showed the best binding energies of Lutein & β-cryptoxanthin ligands with both of the proteins followed by MDS analysis to check the complex stability and physical perturbations to determine the fitness of these complexes as a potential drug agent against COVID-19 infection. The findings of the current study need experimental validations to proceed further for clinical trials.
Capacitive Sensing for Natural Environment Rehabilitation Monitoring
Authors: Pearl Owen , Rokhmanova Nataliya , Dankovich Louis , Faille Summer , Bergbreiter Sarah , Halilaj Eni 
Published: August 2022

Abstract

Inexpensive wearable sensors are expected to transform both research and clinical practice by monitoring patient movement outside of the laboratory and helping personalize the treatment of mobility impairments [1]. To meet these expectations, wearable sensors need to be benchmarked against clinical standards, be robust to placement errors by non-experts, and provide reliable data over long periods of time. Inertial sensing remains the only wearable technology that has been comprehensively characterized and benchmarked against gold-standard biomechanical measurements, but it is sensitive to both drift and placement error [2] and does not provide estimations of muscle activity, which are relevant to numerous mobility impairments. Here we characterize capacitive touch sensing [3] as a gait rehabilitation monitoring technology for the first time, finding that it captures clinically relevant biomechanical measures with the fidelity of laboratory tools. We also show that a circumferential lower-limb capacitive sensing sleeve is more effective than electromyography and musculoskeletal simulations at detecting therapeutically relevant gait modifications used to prevent osteoarthritis progression. Finally, we show that our capacitive sensing approach is robust to placement errors and measurement drift over a 6-hour trial, both of which are insignificant to tracking adherence to therapeutic gait prescriptions. Our results indicate that capacitive sensing wearables could make rehabilitation monitoring outside laboratory environments more feasible and could be used synergistically with other emerging wearable technologies to provide real-time feedback to patients during daily life [4]. We expect this foundational study of capacitive sensing for rehabilitation monitoring to be translatable to other parts of the body and applicable to a wide range of mobility-related pathologies and emerging human-in-the-loop wearable health technologies [5–7].