bluuebunny/crossref_metadata_2025_split huggingface dataset:
Body height in adult women and men in a cross-sectional population-based survey in Geneva: temporal trends, association with general health status and height loss after age 50
Authors: Schäppi Julia , Stringhini Silvia , Guessous Idris , Staub Kaspar , Matthes Katarina L 
Published: July 2022

ObjectiveOn the one hand, trends in average height in adulthood mirror changes in living standard and health status of a population and its subgroups; on the other hand, height in general, as well as the loss of height in older age in particular, are associated in different ways with outcomes for health. For these aspects, there is hardly any information for Switzerland based on representative and measured body height data.DesignRepeated cross-sectional survey study.SettingFully anonymised data from the representative population-based Geneva Bus Santé Study between 2005 and 2017 were analysed.MethodsData from N=8686 study participants were used in the trend analysis. Height was measured and sociodemographic information and self-rated health was collected via questionnaires. Follow-up (mean: 7.1 years) measurements from N=2112 participants were available to assess height loss after age 50.ResultsWomen were, on average, 166.2 cm (SD 6.5) tall and men 179.2 cm (SD 6.5). Among men and women, higher socioeconomic status was associated with taller average height. The flattening of the increase in height from the 1970s birth years appears to begin earlier in the subgroup with the highest education level. The tallest average height was measured for men and women from Central and Northern Europe, the shortest for South America and Asia. The likelihood that participants rated their health as ‘very good’ increased with greater body height. The follow-up data show that men lost −0.11 cm per follow-up year (95% CI −0.12 to −0.10), women −0.17 cm (95% CI −0.18 to 0.15).ConclusionsThe association of height and health status is currently understudied. Monitoring changes in average body height may indicate disparities in different subgroups of populations. Based on our study and a growing literature, we think that the multifaceted role of body height should be better considered in clinical practice.
Does awake prone positioning prevent the use of mechanical respiratory support or death in COVID-19 patients on standard oxygen therapy hospitalised in general wards? A multicentre randomised controlled trial: the PROVID-19 protocol
Authors: Nay Mai-Anh , Planquette Benjamin , Perrin Christophe , Clément Jérémy , Plantier Laurent , Sève Aymeric , Druelle Sylvie , Morrier Marine , Lainé Jean-Baptiste , Colombain Léa , Corvaisier Grégory , Bizien Nicolas , Pouget-Abadie Xavier , Bigot Adrien , Bernard Louis , Nyamankolly Elsa , Fossat Guillaume , Boulain Thierry 
Published: July 2022

IntroductionCOVID-19 is responsible of severe hypoxaemia and acute respiratory distress syndrome (ARDS). Prone positioning improves oxygenation and survival in sedated mechanically patients with ARDS not related to COVID-19. Awake prone positioning is a simple and safe technique which improves oxygenation in non-intubated COVID-19 patients. We hypothesised that early prone positioning in COVID-19 patients breathing spontaneously in medical wards could decrease the rates of intubation or need for noninvasive ventilation or death.Methods and analysisPROVID-19 is an investigator-initiated, prospective, multicentre randomised, controlled, superiority trial comparing awake prone positioning to standard of care in hypoxaemic COVID-19 patients in 20 medical wards in France and Monaco. Patients are randomised to receive either awake prone position plus usual care or usual care alone with stratification on centres, body mass index and severity of hypoxaemia.The study objective is to compare the rate of treatment failure defined as a composite endpoint comprising the need for non-invasive ventilation (at two pressure levels) or for intubation or death, between the intervention group (awake prone position plus usual care) and the usual care (usual care alone) group at 28 days.Ethics and disseminationThe protocol and amendments have been approved by the ethics committees (Comité de protection des personnes Ouest VI, France, no 1279 HPS2 and Comité Consultatif d’Ethique en matière de Recherche Biomédicale, Monaco, no 2020.8894 AP/jv), and patients are included after written informed consent. The results will be submitted for publication in peer-reviewed journals.Trial registration numberNCT04363463.
Adherence to face mask use during the COVID-19 pandemic among women seeking antenatal care in Kinshasa, Democratic Republic of Congo: a facility-based cross-sectional study
Authors: Nkamba Dalau Mukadi , Arena Patrick J , Gadoth Adva , Hoff Nicole A , Dzogang Camille , Kampilu David , Beya Michael , Wong Hui-Lee , Anderson Steven , Kaba Didine , Rimoin Anne W 
Published: July 2022

ObjectivesTo describe face mask use among pregnant women seeking antenatal care (ANC) in Kinshasa, Democratic Republic of Congo and to identify factors associated with masking adherence in this population.DesignFacility-based cross-sectional study nested within a prospective cohort study.SettingRandom sample of 10 health facilities, including 5 primary health centers and 5 secondary facilities or hospitals.ParticipantsA total of 934 pregnant women aged 18 years or above with a gestational age of at least 32 weeks were consecutively surveyed from 17 August 2020 to 31 January 2021.Primary and secondary outcome measuresWe estimated the proportions of pregnant women wearing a face mask and masking correctly (ie, over the mouth and nose), and assessed their knowledge regarding the COVID-19 pandemic. Multivariable logistic regression was employed to identify factors associated with overall and correct face mask use.ResultsOverall, 309 (33.1%) women wore a mask during the interview after their antenatal appointments, but only 33 (10.7%) wore a mask correctly. The odds of masking and correct mask use were significantly higher among women who had their ANC visit in a facility that provided COVID-19 care. Additionally, women who experienced COVID-19-like symptoms in the past 6 months had higher odds of wearing a mask correctly compared with those reporting no recent symptoms. Although 908 (97.2%) women were aware of the COVID-19 pandemic, only 611 (67.3%) thought that COVID-19 was circulating locally in Kinshasa.ConclusionOverall and correct face mask adherence levels were low among pregnant women attending ANC in Kinshasa. Our study highlights the need for improving adherence to correct face mask use in order to help control the spread of COVID-19 within Kinshasa alongside other control measures, like vaccination.
Socioeconomic differences in inpatient care expenditure in the last year of life among older people: a retrospective population-based study in Stockholm County
Authors: Doheny Megan , Schön Pär , Orsini Nicola , Walander Anders , Burström Bo , Agerholm J 
Published: July 2022

ObjectivesTo investigate the association between inpatient care expenditure (ICE) and income group and the effect of demographic factors, health status, healthcare and social care utilisation on ICE in the last year of life.DesignRetrospective population-based study.SettingStockholm County.ParticipantsDecedents ≥65 years in 2015 (N=13 538).OutcomeICE was calculated individually for the month of, and 12 months preceding death using healthcare register data from 2014 and 2015. ICE included the costs of admission and treatment in inpatient care adjusted for the price level in 2018.ResultsThere were difference between income groups and ICE incurred at the 75th percentile, while a social gradient was found at the 95th percentile where the highest income group incurred higher ICE (SEK45 307, 95% CI SEK12 055 to SEK79 559) compared with the lowest income groups. Incurring higher ICE at the 95th percentile was driven by greater morbidity (SEK20 333, 95% CI SEK12 673 to SEK29 993) and emergency department care visits (SEK77 995, 95% CI SEK64 442 to SEK79 549), while lower ICE across the distribution was associated with older age and residing in institutional care.ConclusionGaining insight into patterns of healthcare expenditure in the last year of life has important implications for policy, particularly as socioeconomic differences were visible in ICE at a time of greater care need for all. Future policies should focus on engaging in advanced care planning and strengthening the coordination of care for older people.
Online self-management fall prevention intervention for people with multiple sclerosis: a feasibility study protocol of a parallel group randomised trial
Authors: Kierkegaard Marie , Peterson Elizabeth , Tuvemo Johnson Susanna , Gottberg Kristina , Johansson Sverker , Elf Marie , Flink Maria , Ytterberg Charlotte 
Published: July 2022

IntroductionFalls among people with multiple sclerosis (PwMS) are common and associated with injuries, fear of falling and low health-related quality of life. Considerations of behavioural, environmental, psychological and physical influences (including ambulation status) are needed to meet fall prevention needs for PwMS. Thus, using a codesign process involving key stakeholders a novel online self-management fall prevention intervention was created specifically for ambulatory and non-ambulatory PwMS. The feasibility, acceptability, fidelity and outcome of this complex intervention will be explored. Findings will inform a future full-scale randomised controlled trial.Methods and analysisA mixed-method design will be used. Forty-eight PwMS, stratified for ambulation level, will be randomised to control (n=24) or intervention (n=24). Both groups will receive a brochure about fall risk factors and fall prevention. The intervention is group-based (eight PwMS in each group); will be delivered online; and involve six, 2-hour weekly sessions and a booster session 8 weeks after the sixth session. Each intervention group will be led by a trained facilitator. Data collection will be performed at baseline, and after seven and 18 weeks. Outcome measures will capture data on fall prevention behaviours, fear of falling, falls self-efficacy, social and everyday activities, perceived impact of MS and number of falls. Feasibility of recruitment process, data collection procedures, outcome measures, and delivery, and intervention acceptability, fidelity and outcomes will be evaluated. Both quantitative and qualitative methods will be used.Ethics and disseminationEthical approval has been obtained from the Swedish Ethical Review Authority (registration number 2021-04817). Results will be disseminated in peer-review journals, at conferences, research meetings, in social media and through the patient organisation Neuro Sweden.Trial registration numberNCT04317716.
Consensus on patient cases for hospitalised children with a high paediatric track and trigger tool score that raises no mounting concern: a Delphi process study
Authors: Jensen Claus Sixtus , Olesen Hanne Vebert , Kirkegaard Hans , Lisby Marianne 
Published: July 2022

BackgroundPaediatric track and trigger tools (PTTTs) based on vital parameters have been implemented in hospitals worldwide to help healthcare professionals identify signs of critical illness and incipient deterioration in hospitalised children. It has been documented that nurses do not use PTTT as intended, but deviate from PTTT protocols because, in some situations, PTTT observations make little sense to them. The present study aimed to reach consensus on whether automatically generated PTTT scores that are higher than deemed reasonable by healthcare professionals according to their professional experience and clinical expertise may be downgraded.MethodsA two-round modified Delphi technique was used to explore consensus on 14 patient cases for hospitalised children with a high PTTT score that did not raise concerns by systematically collating questionnaire responses. Participants rated their level of agreement on a 9-point Likert scale. IQR and median were calculated for each case.FindingsA total of 221 participants completed round 1 and 101 participants completed round 2. Across the two rounds, majority of the participants were from paediatric departments, nurses and women. In round 1, consensus on inclusion was reached on 2 of the 14 cases. In round 2, consensus was reached on one additional patient case. Three of the 11 non-consensus cases remaining after rounds 1 and 2 were included by the research group based on predefined criteria.ConclusionIn conclusion, a consensus opinion was achieved on six patient cases where the child had a high PTTT score but where the healthcare professionals were not as concerned as indicated by the PTTT score.
Comparison of ammonium, nitrate, and proton fluxes in mycorrhizal and nonmycorrhizal roots of lodgepole pine in contrasting nitrogen treatments
Authors: Hawkins Barbara J. , Robbins Samantha 
Published: July 2022

Relatively few comparative studies exist of nitrogen (N) uptake by ectomycorrhizal (EM) and nonmycorrhizal roots under controlled conditions. Instantaneous and long-term N uptake by EM and nonmycorrhizal roots of lodgepole pine seedlings ( Pinus contorta (Douglas) var. latifolia (Engelm.)) were compared after 9–12 months of preconditioning under high or low N supply, with NH4+ and NO3− in proportions of 90:10 and 10:90. EM roots were inoculated with Amphinema byssoides or Laccaria bicolor. Instantaneous net NH4+, NO3−, and H+ fluxes were measured simultaneously on seedling roots with a microelectrode ion flux measurement system, and seedling organ biomass and N content were measured to infer long-term N uptake. Net NH4+ uptake was observed in EM roots of lodgepole pine but NH4+ efflux was observed in nonmycorrhizal roots. Greater instantaneous N uptake in EM roots was supported by higher root and shoot N contents in seedlings associated with L. bicolor than in noninoculated seedlings. Absence of NH4+ efflux in EM roots suggests that root colonization by EM fungi has the potential to reduce futile cycling of NH4+. EM lodgepole pine appeared to prefer NH4+ over NO3− as an N source and instantaneous NH4+ uptake rates were higher in NH4-starved roots. H+ efflux was observed in most roots. Future work should focus on a greater variety of EM species to explore differences among species in N uptake.
YourAdvalue
Authors: Pachilakis Michalis , Papadopoulos Panagiotis , Laoutaris Nikolaos , Markatos Evangelos P. , Kourtellis Nicolas 
Published: July 2022

The Real Time Bidding (RTB) protocol is by now more than a decade old. During this time, a handful of measurement papers have looked at bidding strategies, personal information flow, and cost of display advertising through RTB. In this paper, we present YourAdvalue, a privacy-preserving tool for displaying to end-users in a simple and intuitive manner their advertising value as seen through RTB. Using YourAdvalue, we measure desktopRTB prices in the wild, and compare them with desktop and mobileRTB prices reported by past work. We present how it estimates ad prices that are encrypted, and how it preserves user privacy while reporting results back to a data-server for analysis. We deployed our system, disseminated its browser extension, and collected data from 200 users, including 12000 ad impressions over 11 months.
By analyzing this dataset, we show that desktop RTB prices have grown 4.6x over desktop RTB prices measured in 2013, and 3.8x over mobile RTB prices measured in 2015. We also study how user demographics associate with the intensity of RTB ecosystem tracking, leading to higher ad prices. We find that exchanging data between advertisers and/or data brokers through cookie- syncronization increases the median value of displayed ads by 19%. We also find that female and younger users are more targeted, suffering more tracking (via cookie synchronization) than male or elder users. As a result of this targeting in our dataset, the advertising value (i) of women is 2.4x higher than that of men, (ii) of 25-34 year-olds is 2.5x higher than that of 35-44 year-olds, (iii) is most expensive on weekends and early mornings.
Argus
Authors: Regmi Hem , Sur Sanjib 
Published: July 2022

We propose Argus, a system to enable millimeter-wave (mmWave) deployers to quickly complete site-surveys without sacrificing the accuracy and effectiveness of thorough network deployment surveys. Argus first models the mmWave reflection profile of an environment, considering dominant reflectors, and then uses this model to find locations that maximize the usability of the reflectors. The key component in Argus is an effective deep learning model that can map the visual data to the mmWave signal reflections of an environment and can accurately predict mmWave signal profile at any unobserved locations. It allows Argus to find the best picocell locations to provide maximum coverage and also lets users self-localize accurately anywhere in the environment. Furthermore, Argus allows mmWave picocells to predict device's orientation accurately and enables object tagging and retrieval for VR/AR applications.
We implement and validate Argus on two different buildings consisting of multiple different indoor environments. However, the generalization capability of Argus can easily update the model for unseen environments; so, Argus can be deployed to any indoor environment with little or no model fine-tuning.
PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma
Authors: Wang Jun-Cheng , Chen Dong-Ping , Lu Shi-Xun , Chen Jin-Bin , Wei Yuan , Liu Xue-Chao , Tang Yu-Hao , Zhang Rongxin , Chen Jian-Cong , Kan Anna , Xu Li , Zhang Yao-Jun , Hou Jiajie , Kuang Dong-Ming , Chen Min-Shan , Zhou Zhong-Guo 
Published: July 2022

Abstract

Cancer immunotherapy restores or enhances the effector function of T cells in the tumor microenvironment, but the efficacy of immunotherapy has been hindered by therapeutic resistance. Here, we identify the proto-oncogene serine/threonine protein kinase PIM2 as a novel negative feedback regulator of IFNγ-elicited tumor inflammation, thus endowing cancer cells with aggressive features. Mechanistically, IL1β derived from IFNγ-polarized tumor macrophages triggered PIM2 expression in cancer cells via the p38 MAPK/Erk and NF-κB signaling pathways. PIM2+ cancer cells generated by proinflammatory macrophages acquired the capability to survive, metastasize, and resist T-cell cytotoxicity and immunotherapy. A therapeutic strategy combining immune checkpoint blockade (ICB) with IL1β blockade or PIM2 kinase inhibition in vivo effectively and successfully elicited tumor regression. These results provide insight into the regulatory and functional features of PIM2+ tumors and suggest that strategies to influence the functional activities of inflammatory cells or PIM2 kinase may improve the efficacy of immunotherapy.

Significance:
Cross-talk between T cells and macrophages regulates cancer cell PIM2 expression to promote cancer aggressiveness, revealing translational approaches to improve response to ICB in hepatocellular carcinoma.
DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome
Authors: Guidry Kayla , Vasudevaraja Varshini , Labbe Kristen , Mohamed Hussein , Serrano Jonathan , Guidry Brett W. , DeLorenzo Michael , Zhang Hua , Deng Jiehui , Sahu Soumyadip , Almonte Christina , Moreira Andre L. , Tsirigos Aristotelis , Papagiannakopoulos Thales , Pass Harvey , Snuderl Matija , Wong Kwok-Kin 
Published: July 2022

Abstract

Purpose:
Lung adenocarcinoma (LUAD) is a clinically heterogeneous disease, which is highlighted by the unpredictable recurrence in low-stage tumors and highly variable responses observed in patients treated with immunotherapies, which cannot be explained by mutational profiles. DNA methylation–based classification and understanding of microenviromental heterogeneity may allow stratification into clinically relevant molecular subtypes of LUADs.

Experimental Design:
We characterize the genome-wide DNA methylation landscape of 88 resected LUAD tumors. Exome sequencing focusing on a panel of cancer-related genes was used to genotype these adenocarcinoma samples. Bioinformatic and statistical tools, the immune cell composition, DNA methylation age (DNAm age), and DNA methylation clustering were used to identify clinically relevant subgroups.

Results:
Deconvolution of DNA methylation data identified immunologically hot and cold subsets of LUADs. In addition, concurrent factors were analyzed that could affect the immune microenvironment, such as smoking history, ethnicity, or presence of KRAS or TP53 mutations. When the DNAm age was calculated, a lower DNAm age was correlated with the presence of a set of oncogenic drivers, poor overall survival, and specific immune cell populations. Unsupervised DNA methylation clustering identified six molecular subgroups of LUAD tumors with distinct clinical and microenvironmental characteristics.

Conclusions:
Our results demonstrate that DNA methylation signatures can stratify LUAD into clinically relevant subtypes, and thus such classification of LUAD at the time of resection may lead to better methods in predicting tumor recurrence and therapy responses.
Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma
Authors: Denize Thomas , Hou Yue , Pignon Jean-Christophe , Walton Emily , West Destiny J. , Freeman Gordon J. , Braun David A. , Wu Catherine J. , Gupta Saurabh , Motzer Robert J. , Atkins Michael B. , McDermott David , Choueiri Toni K. , Shukla Sachet A. , Signoretti Sabina 
Published: July 2022

Abstract

Purpose:
PD-L1 expression on tumor cells (TC) is associated with response to anti-PD-1-based therapies in some tumor types, but its significance in clear cell renal cell carcinoma (ccRCC) is uncertain. We leveraged tumor heterogeneity to identify molecular correlates of TC PD-L1 expression in ccRCC and assessed their role in predicting response to anti-PD-1 monotherapy.

Experimental Design:
RNA sequencing was performed on paired TC PD-L1 positive and negative areas isolated from eight ccRCC tumors and transcriptomic features associated with PD-L1 status were identified. A cohort of 232 patients with metastatic ccRCC from the randomized CheckMate-025 (CM-025) trial was used to confirm the findings and correlate transcriptomic profiles with clinical outcomes.

Results:
In both the paired samples and the CM-025 cohort, TC PD-L1 expression was associated with combined overexpression of immune- and cell proliferation–related pathways, upregulation of T-cell activation signatures, and increased tumor-infiltrating immune cells. In the CM-025 cohort, TC PD-L1 expression was not associated with clinical outcomes. A molecular RCC subtype characterized by combined overexpression of immune- and cell proliferation–related pathways (previously defined by unsupervised clustering of transcriptomic data) was enriched in TC PD-L1 positive tumors and displayed longer progression-free survival (HR, 0.32; 95% confidence interval, 0.13–0.83) and higher objective response rate (30% vs. 0%, P = 0.04) on nivolumab compared with everolimus.

Conclusions:
Both TC-extrinsic (immune-related) and TC-intrinsic (cell proliferation–related) mechanisms are likely intertwined in the regulation of TC PD-L1 expression in ccRCC. The quantitation of these transcriptional programs may better predict benefit from anti-PD-1-based therapy compared with TC PD-L1 expression alone in ccRCC.