bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Significance of Volume Status in Body Composition and Physical Performance Measurements in Hemodialysis Patients
Authors: Kim Jun Chul , Do Jun Young , Kang Seok Hui 
Published: March 2022

IntroductionThis study aimed to evaluate the association between volume status and body composition or physical performance measurements in hemodialysis patients.MethodsA total of 84 patients were enrolled in this study. The participants were divided into tertiles based on the edema index (extracellular water/total body water): low, middle, and high tertiles. Serum albumin and serum high-sensitivity C-reactive protein levels were measured. The appendicular lean mass index (ALM/Ht2, kg/m2) was measured using dual-energy X-ray absorptiometry. The thigh muscle area index (TMA/Ht2, cm2/m2) was measured using CT. Extracellular and total body water and phase angles were obtained using bioimpedance analysis. The results of the subjective global assessment (SGA), hand-grip strength (HGS), gait speed (GS), short physical performance battery (SPPB), sit-to-stand for 30-second (STS30) test, timed up and go (TUG), sit-to-stand test performed five times (STS5), and 6-minute walk (6-MW) tests were also evaluated.ResultsOn the univariate analysis, the SGA score and phase angle in the high tertile group were the lowest among the three groups. On multivariate analysis, TMA/Ht2 and phase angle in the high tertile were the lowest among the three groups. Inverse correlations were observed between edema index and TMA/Ht2, SGA score, phase angle, HGS, GS, SPPB, STS30, or 6-MW. Positive correlations were observed between the edema index and the STS5 or TUG test. The sensitivity and specificity for predicting low GS were 34.5 and 89.7%, respectively. The values for predicting low SPPB were 68.0 and 79.7%, respectively.ConclusionThis study demonstrates that high volume status may be associated with decreased muscle mass and physical performance regardless of inflammatory or nutritional status.
Lipid-Lowering Efficacy of the Capsaicin in Patients With Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Jiang Zhonghui , Qu Hua , Lin Gongyu , Shi Dazhuo , Chen Keji , Gao Zhuye 
Published: March 2022

BackgroundPatients with metabolic syndrome (MetS) have increased cardiovascular risk. Capsaicin (CAP) has been shown to reduce lipids, but efficacy for patients with MetS is unknown.MethodsA systematic review was performed according to PRISMA guidelines, to compare the effects of CAP against a placebo. Differences in the weight mean difference (WMD) with 95% confidence intervals (95% CI) were then pooled using a random effects model.ResultsNine randomized controlled trials including 461 patients were identified in the overall analysis. CAP significantly decreased total cholesterol (TC) (WMD = −0.48, 95% CI: −0.63 to −0.34, I2= 0.00%) and low-density lipoprotein cholesterol (LDL-C) (WMD = −0.23, 95% CI: −0.45 to −0.02, I2 = 68.27%) among patients with MetS. No significant effects of CAP were found on triglycerides (TG) or high-density lipoprotein cholesterol (HDL-C) (WMD = −0.40, 95% CI: −1.50 to 0.71, I2 = 98.32%; WMD = −0.08, 95% CI: −0.21 to 0.04, I2 = 86.06%). Subgroup analyses indicated that sex and intervention period were sources of heterogeneity. The results revealed that CAP decreased TG levels in women (WMD = −0.59, 95% CI: −1.07 to −0.10) and intervention period &lt;12 weeks (WMD = −0.65; 95% CI: −1.10 to −0.20). And there was no potential publication bias according to funnel plot, Begg' test and Egger regression test.ConclusionsCAP supplementation is a promising approach to decreasing TC and LCL-C levels in patients with MetS. However, short-term (&lt;12 weeks) use of CAP in women may also reduce TG levels.Systematic Review RegistrationIdentifier: CRD42021228032.
The Chaperone Protein GRP78 Promotes Survival and Migration of Head and Neck Cancer After Direct Radiation Exposure and Extracellular Vesicle-Transfer
Authors: Schneider Michael , Winkler Klaudia , Kell Rosemarie , Pfaffl Michael W. , Atkinson Michael J. , Moertl Simone 
Published: March 2022

Background and PurposeIncreased levels of the chaperone protein GRP78 have been implicated in poorer outcomes of cancer therapy. We have therefore explored the functional connection between the expression of GRP78 and the development of radioresistance and metastatic behavior in HNSCC.Material and MethodsThe association between gene expression of GRP78 and survival in HNSCC patients was examined using the TCGA database. The influence of ionizing radiation on the GRP78 levels in HNSCC cell lines, their secreted extracellular vesicles (EV) and non-irradiated EV-recipient cells was investigated by Western Blot and FACS. The consequences of chemical inhibition or experimental overexpression of GRP78 on radioresistance and migration of HNSCC cells were analyzed by clonogenic survival and gap closure assays.ResultsElevated levels of GRP78 RNA in HNSCC correlated with poorer overall survival. Radiation increased GRP78 protein expression on the surface of HNSCC cell lines. Experimental overexpression of GRP78 increased both radioresistance and migratory potential. Chemical inhibition of GRP78 impaired cell migration. EVs were identified as a potential source of increased GRP78 content as elevated levels of surface GRP78 were found in EVs released by irradiated cells. These vesicles transferred GRP78 to non-irradiated recipient cells during co-cultivation.ConclusionsWe have identified the chaperone protein GRP78 as a potential driver of increased radioresistance and motility in HNSCC. The uptake of GRP78-rich EVs originating from irradiated cells may contribute to a poorer prognosis through bystander effects mediated by the transfer of GRP78 to non-irradiated cells. Therefore, we consider the chaperone protein GRP78 to be an attractive target for improving radiotherapy strategies.
Systematic Review of Olaparib in the Treatment of Recurrent Platinum Sensitive Ovarian Cancer
Authors: Chen Qian , Li Xiaoli , Zhang Zhen , Wu Tong 
Published: March 2022

ObjectiveTo systematically evaluate the efficacy and safety of olaparib in the treatment of recurrent platinum-sensitive ovarian cancer.MethodsThe Cochrane Library, PubMed, Chinese Biomedical Literature Database, CNKI, VIP Database, Wanfang Science and Technology Database were searched for randomized controlled trials (RCTs) of olaparib in the treatment of recurrent platinum-sensitive ovarian cancer from the establishment of each database to January 2022. Two reviewers independently evaluated the quality of the literature, extracted the data, and cross-checked the methodological quality. Meta-analysis was performed using RevMan 5.4 software.ResultsA total of 7 RCTs were included, including 2406 patients, There were 1497 patients in treatment groups and 909 patients in the control group. Meta-analysis results showed that in terms of effectiveness, the overall survival time of patients in the olaparib group [HR=1.24, 95%CI(1.06, 1.45), P=0.006]; in terms of safety, for all grades of adverse events (including nausea, fatigue, vomiting, diarrhea, abdominal pain, and headache), [HR=1.54, 95%CI(1.38, 1.71), P=0.0002], for grade 3 or higher adverse events (including nausea, fatigue, vomiting, diarrhea, abdominal pain, and headache), [HR=2.13, 95%CI(1.61, 2.81), P=0.003], there were significant differences compared with the control group, suggesting that the risk of adverse reactions in the experimental group was higher than that in the control group. Subgroup analysis showed that only abdominal pain, headache and vomiting were not statistically significant, and other adverse reactions were statistically significant.ConclusionBased on the existing clinical evidence, olaparib in the treatment of recurrent platinum-sensitive ovarian cancer has a longer overall survival than the control group. It is an ideal regimen, but the incidence of adverse reactions is high.
The Clinical Outcomes, Prognostic Factors and Nomogram Models for Primary Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy
Authors: Luo Li-Mei , Wang Ying , Lin Pei-Xian , Su Chuang-Huang , Huang Bao-Tian 
Published: March 2022

PurposeStereotactic body radiation therapy (SBRT) is a standard treatment for early primary lung cancer patients. However, there are few simple models for predicting the clinical outcomes of these patients. Our study analyzed the clinical outcomes, identified the prognostic factors, and developed prediction nomogram models for these patients.Materials and MethodsWe retrospectively analyzed 114 patients with primary lung cancer treated with SBRT from 2012 to 2020 at our institutions and assessed patient’s clinical outcomes and levels of toxicity. Kaplan–Meier analysis with a log-rank test was used to generate the survival curve. The cut-off values of continuous factors were calculated with the X-tile tool. Potential independent prognostic factors for clinical outcomes were explored using cox regression analysis. Nomograms for clinical outcomes prediction were established with identified factors and assessed by calibration curves.ResultsThe median overall survival (OS) was 40.6 months, with 3-year OS, local recurrence free survival (LRFS), distant disease-free survival (DDFS) and progression free survival (PFS) of 56.3%, 61.3%, 72.9% and 35.8%, respectively, with grade 3 or higher toxicity rate of 7%. The cox regression analysis revealed that the clinical stage, immobilization device, and the prescription dose covering 95% of the target area (D95) were independent prognostic factors associated with OS. Moreover, the clinical stage, and immobilization device were independent prognostic factors of LRFS and PFS. The smoking status, hemoglobin (Hb) and immobilization device were significant prognostic factors for DDFS. The nomograms and calibration curves incorporating the above factors indicated good predictive accuracy.ConclusionsSBRT is effective and safe for primary lung cancer. The prognostic factors associated with OS, LRFS, DDFS and PFS are proposed, and the nomograms we proposed are suitable for clinical outcomes prediction.
Associations Between Parental Occupational Balance, Subjective Health, and Clinical Characteristics of VLBW Infants
Authors: Dür Mona , Röschel Anna , Oberleitner-Leeb Christiane , Herrmanns Verena , Pichler-Stachl Elisabeth , Mattner Barbara , Pernter Silvia-Desiree , Wald Martin , Urlesberger Berndt , Kurz Herbert , Frischer Thomas , Zwiauer Karl , Matter Inu Sarah , Berger Angelika 
Published: March 2022

ObjectiveVery low birthweight (VLBW) infants have an increased risk of mortality and frequently suffer from complications, which affects parental occupational balance. Occupational balance is the satisfaction with one's meaningful activities, which include everyday activities that people need to, want to, and are expected to do. In contrast to work-life balance, the construct of occupational balance addresses different activities equally and it applies to all persons, regardless of whether they are working or not. Parental occupational balance might be related to parents' and VLBW infants' health. Therefore, the objective of this study was to investigate associations between parental occupational balance, subjective health, and clinical characteristics of VLBW infants.MethodsA cross-sectional multicenter study was conducted in six Austrian neonatal intensive care units. Occupational balance and subjective health of parents of VLBW infants were assessed with six self-reported questionnaires. The following clinical characteristics of VLBW infants were extracted from medical records: gestational age, birthweight, Apgar scores, Clinical Risk for Babies II Score, and complications of prematurity. Spearman's rank coefficients were calculated.ResultsIn total, 270 parents, 168 (62%) female and their VLBW infants, 120 (44%) female, were included in this study. Parents' mean age was 33.7 (±6.0) years, mean gestational age of VLBW infants was 27 + 3 (±2) weeks. Associations between parental occupational balance, subjective health, and clinical characteristics of VLBW infants were identified (rs = 0.13 – 0.56; p ≤ 0.05), such as the correlation between occupational areas (rs = 0.22, p ≤ 0.01), occupational characteristics (rs = 0.17, p = 0.01), and occupational resilience (rs = 0.18, p ≤ 0.01) with bronchopulmonary dysplasia of VLBW infants.ConclusionOccupational balance is associated with parents' and VLBW infants' health. Interventions to strengthen parental occupational balance might increase parental health and thereby also improve health and developmental outcomes of their VLBW infants.
Overview of Cannabis including Kampo Medicine and Therapy for Treatment of Dementia: A Review
Authors: Wenger Tibor , Watanabe Kazuhito , Sasaki Yui , Kanazawa Keiko , Shimizu Koichi , Sirikantaramas Supaart , Shoyama Yoshinari , Taura Futoshi , Morimoto Satoshi , Shoyama Yukihiro 
Published: March 2022

Cannabis sativa L. is an annual herb oldest cultivated plants as a source of fiber since about 5000 B.C. On the other hand, the cannabis flower and seed are listed in Shennong’s classic Materia Medica approximately 2000 years ago. The formulas prescribed with cannabis in Kampo medicine have been summarized. Cannabidiol (CBD) and tetrahydrocannabinol (THC) are the major neurological and psychiatric cannabinoids, and develop to drugs. It becomes evident that the therapeutic CBD and/or THC are the important candidate of anti-dementia drugs having different mechanism for Alzheimer’s patients. Two receptors and endocannabinoids are also discussed for underlying mechanism of action. In order to promote the breeding of cannabis plant containing higher concentration of target cannabinoid the biosynthetic enzymes were isolated, cloning and the tertiary structure of THCA synthase determined by x-ray analysis resulting in the possibility of molecular breeding for cannabinoids.
Gender Differences in Burnout Among Endocrinologists in China
Authors: Wang Jing , Zhang Lufa , Jiang Feng , Liu Yuanli , Wang Mingxiao , Wu Yinuo , Tang Yi-Lang 
Published: March 2022

ObjectiveTo survey the prevalence of burnout in a national sample of endocrinologists in China and to examine its correlates, with a special focus on gender differences.MethodsAn anonymous online survey was conducted among endocrinologists in 31 provincial government-owned “People’s Hospitals” of each province in mainland China. Demographic and work-related factors were collected from participants. The Maslach Burnout Inventory-Human Services Survey (MBI-HSS) was used to assess burnout, including emotional exhaustion (EE), depersonalization (DP), and reduced personal accomplishment (PA).ResultsA total of 711 endocrinologists (72.1% were female and mean age was 39.63 ± 8.51 years old) completed the survey. Burnout was reported by 32.8% of the participants. There were no significant gender differences in the overall prevalence of burnout or EE, DP, and PA (all p &gt; 0.05). A multi-level linear regression revealed: (1) In male participants, PA was significantly associated with age (β = 0.03, p = 0.003), DP was inversely associated with age (β = −0.06, p = 0.005), EE was significantly associated with shorter sleep duration (β = −0.25, p = 0.006), and longer work hours (β = 0.01, p = 0.016). (2) In females, PA was significantly associated with age (β = 0.01, p = 0.038), EE and DP were both significantly associated with shorter sleep duration (β = −0.19, p = 0.001; and β = −0.15, p = 0.011, respectively). EE and DP were also associated with work hours (β = 0.02, p &lt; 0.001; and β = 0.01, p &lt; 0.001, respectively).ConclusionNearly one-third of endocrinologists in China experienced burnout. Although there were no significant gender differences in the prevalence of overall burnout or EE, DP, and PA scores, male and female participants differed in factors associated with EE, DP, and PA. Interventions need to be tailored to target different aspects in male and female endocrinologists and target different subgroups.
THE EFFECT OF CAPITAL ADEQUACY RATIO (CAR), COST EFFICIENCY RATIO (CER), AND NET INTEREST MARGIN (NIM) ON PROFITABILITY (Study on Sub-Sector Banking Companies Listed on the Indonesia Stock Exchange for the period 2017-2019)
Authors: Pratama Aldi , Lilia Wirda 
Published: March 2022

Abstract
The purpose of this study was to analyze the effect of the variable Capital Adequacy Ratio (CAR), Cost Efficiency Ratio (CER), and Net Interest Margin (NIM) on the profitability of sub-sector banking companies listed on the Indonesia Stock Exchange for the period 2017-2019. This type of research uses quantitative methods. This study uses a sample of companies in the sub-sector banking listed on the Indonesia Stock Exchange. Based on the purposive sampling technique, it was obtained a sample of 27 companies by 43 companies of total population. The data used in this study are secondary data in the form of corporate financial reports obtained from the website www.idx.co.id. The results showed that partially and simultaneously the CAR, CER, and NIM variables had a significant effect on profitability.

Keywords: Capital Adequacy Ratio (CAR), Cost Efficiency Ratio (CER), Net Interest Margin (NIM), Profitability.
İnsan Endometriyum Epitel Hücrelerinde Farklı Kontrollü Ovaryan Hipersitümulasyonu Protokollerinin Eksozom Belirteci CD63 Üzerine Etkisi
Authors: ÖZGÜL ÖNAL Melike , UYAR Yıldız , ÖZTÜRK Ulviye Cansu , VATANSEVER Seda 
Published: March 2022

Giriş ve Amaç: Eksozomlar; protein, mRNA ve miRNA’ları taşıyan ve hedefledikleri hücrelerde/dokularda fonksiyonel değişikliklere neden olan kargo sistemleridir. CD63, eksozomların tanımlanması ve izolasyonu için anahtar proteindir. Kontrollü ovaryan hiperstimülasyonu (KOH) protokollerinde kullanılan farmakolojik ajanların oosit sayısını ve kalitesini arttırarak ovulasyonu indüklediği bilinmekte fakat endometriyum hücreleri üzerindeki etkileri tam olarak bilinmemektedir. Bu çalışmada; CRL-1671 insan endometriyum hücrelerinde, KOH protokollerinde kullanılan ilaçlarının eksozom belirteci olan CD63 üzerine etkilerinin değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntemler: CRL-1671 hücreleri; kontrol grubu, büyüme hormonu (GH) uygulanan grup, Gonadotropin (GnTR) uygulanan grup, GH+GnTR uygulanan grup, Letrozol (L)+GnTR uygulanan grup ve üçlü kombine (L+GnTR+GH) grubu olacak şekilde 8 gün boyunca kültüre edildi. İnkübasyon sonunda hücrelerde CD63 dağılımı indirekt-immunositokimya tekniği ile incelendi.
Bulgular: CD63 immunoreaktivitesinin kontrol grubunda orta (++), GnTR ve L+GnTR gruplarında kuvvetli (+++) ve diğer ilaç uygulanan gruplarda orta (++) şiddette olduğu gözlendi. H-score değerleri sırası ile 298 ± 6,71; 300 ± 5; 397 ± 12,55; 303 ± 2,74; 302 ± 5,70 ve 391 ± 4,18 olarak hesaplandı. Kontrol grubu ile karşılaştırıldığında GnTR ve L+GnTR uygulanan gruplarda istatistiksel anlamlı farklılık belirlendi (p
Manisa Yöresinde Beta-Talasemi Mutasyon Dağılımı
Authors: KADER Şebnem , GULEN Huseyin , TANELİ Fatma 
Published: March 2022

Giriş ve Amaç: Beta (β)-talasemi, Türkiye’deki en yaygın genetik bozukluklardan biridir. Bu çalışmanın amacı Manisa ili ve çevresindeki β-talasemi mutasyonlarının tipini ve dağılımını tespit etmek, Manisa'nın Türkiye β-talasemi mutasyon haritasındaki yerini belirlemektir.
Gereç ve Yöntemler: Bu çalışma; Etik Kurul onayı alındıktan sonra Celal Bayar Üniversitesi Üniversitesi Tıp Fakültesi, Çocuk Hematoloji Bilim Dalı’ nda prospektif olarak gerçekleştirildi. Çalışmaya, β-talasemi major ve β-talasemi taşıyıcılığı tanısıyla takip edilen 85 hasta alındı. β-talasemi taşıyıcılarında çalışmaya dahil edilme kriteri olarak HbA2 düzeyinin % 3.5’in üzerinde olması dikkate alındı. Beta Globin Strip Assay yöntemi ile beta globin geninde sıklıkla görülen ve Akdeniz ülkelerine özgü 22 mutasyon tarandı.
Bulgular: Çalışmaya dahil edilen 85 hastanın 15’inde, taranan 22 mutasyondan hiç birinde pozitiflik saptanmadı. Kalan 70 hastanın 2 tanesinin birleşik heterozigot formunda (%2.8), 1 hastanın homozigot formunda (1.4), 67 hastanın da heterozigot formunda (%95.8) mutant allel taşıdığı tespit edildi. En yaygın görülen β-talasemi mutasyonu, Türkiye genelinde olduğu gibi IVS1-110 (% 35.3) olarak bulundu. Bunu sırasıyla IVS2-1 (%14.1), codon 39 (%8.2), IVS2-745 (%7.1), IVS1-6 (%5.9), IVS1-1 (%3.5), codon 5 (%2.4), codon 8 (%3.5), codon 44 (%2.4), -87 (%1.2), codon 36/37 (%1.2) mutasyonları takip etti.
-30, HbC, HbS, codon 6, codon 8/9, codon 22, codon 30, IVS1-2, IVS1-5, IVS1-116, IVS1-25, codon 44 mutasyonları hiçbir hastamızda tespit edilmedi.
Sonuç: Çalışmamızda beta globin strip assay testinin sensivitesi % 82.3 oranında bulundu. Beta-Talasemi mutasyonları açısından Türkiye’deki genel ortalamanın Manisa’da da değişmediği, IVS1-110 mutasyon tipinin Manisa’da da en sık mutasyon olduğu bulundu. Manisa ilinde talasemi taşıyıcılığının % 4.5 gibi yüksek bir oranda bulunmasının yanı sıra en çok göç alan iller arasında yer alan ilimizde akraba evliliğinin fazla görülmesinden dolayı prenatal tanı merkezlerinin arttırılması ve bir halk sağlığı sorunu olan bu konu üzerinde aktif olarak çalışılması gerektiğini düşünmekteyiz.
Platelet Variability İndex’in Serebrovasküler Olaylardaki Tanısal Değerinin Değerlendirilmesi Ve Önemi
Authors: ŞİMŞEK Bora , SAĞLAM GÜRMEN Ekim 
Published: March 2022

Giriş ve Amaç: Akut inmeye bağlı mortalite ve morbidite oranları yüksek olduğundan bu hastaların erken prognoz öngörüsünü yapmak önemlidir. Acil serviste iskemik ya da hemorajik inme tanısı alan hastaların Ortalama trombosit hacmi (MPV), Platelet (PLT) ve MPV/PLT değerleri ile hastaların demografik özellikleri, triaj kodu, sonlanımı, hastaların vital parametreleri ve Glaskow Koma Skalası (GKS) arasındaki ilişki değerlendirilmeye çalışılmıştır.
Gereç ve Yöntemler: Bu çalışma 3. Basamak Üniversite Hastanesi Acil servisine başvuran 18 yaş üstü, yapılan tetkikler neticesinde iskemik veya hemorajik inme tanısı alan 200 hasta üzerinde retrospektif olarak yapılmıştır.
Bulgular: Çalışmamıza 116 (%58)’sı erkek olmak üzere toplam 200 hasta dahil edilmiştir. Hastaların yaş ortalaması 68 yıl olarak tespit edilmiştir. Hastaların 178 (%89)’inin iskemik, 22 (%11)’sinin hemorajik inme tanısı aldığı görüldü. Hastaların yaşı ve MPV/PLT oranları arasında korelasyon bulunmuştur (p
Pre-menopozal Dönemdeki Kadınlarda Dairesel Antrenman Eğitiminin Vücut Kompozisyonuna Etkisi
Authors: BASKAN Özden , BASKAN Emre , YAĞCI Nesrin 
Published: March 2022

Giriş ve Amaç: Çalışmamız premenopozal dönemdeki kadınlarda dairesel antrenman eğitiminin vücut kompozisyonuna etkisini araştırmak amacıyla planlanmıştır.
Gereç ve Yöntemler: Bu çalışmaya Denizli’de yaşayan premenopozal dönemde olan 35-53 yaşları arasında 49 kadın (ortalama yaş: 39,32±4,16 yıl.) dâhil edilmiştir. Kadınlara 8 hafta dairesel antrenman eğitimi (haftada 5 gün, günde 1 kez 30 dakika) bir Fizyoterapist tarafından verilmiştir. Bu eğitim kişilerin kendi kapasite ve hızlarına uygun olarak 9 adet izokinetik istasyon çalışması ve aerobik egzersizlerden oluşmaktadır. Çalışma, 30 saniye yüklenme, 30 saniye aerobik egzersizden oluşmuştur. Egzersiz istasyonları abdominal, sırt, kalça, diz, omuz ve dirsek çalışmalarını içermektedir. Eğitimden önce ve 8 hafta sonra vücut kompozisyonuna ait ölçümler (göğüs, bel, kalça, üst ekstremite ve alt ekstremite çevre ölçümleri ve baskül ile vücut ağırlığı, yağ ve su miktarı) alınmıştır.
Nutrisyonel Risk Taraması Ölçeği (Nutritional Risk Screening) kullanılarak toplanmıştır.
Bulgular: 8 haftalık eğitim sonunda çalışmaya alınan kadınların vücut ağırlığı önemli düzeyde azalmıştır (p=0,0001). Vücut kompozisyonuna ait ölçümler karşılaştırıldığında su ve kas miktarı (p>0,05) hariç tüm ölçümlerde eğitim sonunda önemli düzeyde azalma meydana gelmiştir (p=0,0001).
Sonuç: Çalışmamızın sonuçları göstermiştir ki premenopozal dönemdeki kadınlarda dairesel antrenman eğitimi vücut kompozisyonuna olumlu yönde etki etmektedir.