bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe alveolar bone resorption in Felty syndrome: a case report
Authors: Morikawa Satoru , Miyashita Yoko , Nasu Mana , Shibazaki Shunichi , Usuda Satoshi , Tsunoda Kazuyuki , Nakagawa Taneaki 
Published: December 2022

Abstract
Background
Felty syndrome is defined by three conditions: neutropenia, rheumatoid arthritis, and splenomegaly. Neutropenia associated with pancytopenia may further affect the dental condition of a patient. Periodontal treatment and surgery in patients with Felty syndrome necessitates cooperation with a hematologist. Here we present a case of a patient with Felty syndrome who was initially referred to the oral surgery hospital attached to the School of Dentistry for extensive periodontitis. She was effectively treated in collaboration with the hematology department.

Case presentation
A 55-year-old Asian woman visited our department with concerns of worsening tooth mobility, discomfort, and spontaneous gingival bleeding. Initial periodontal examination revealed generalized severe periodontitis (Stage IV Grade C) resulting from leukopenia/neutropenia and poor oral hygiene. A thorough treatment strategy involving comprehensive dental procedures, such as multiple extractions and extensive prosthetic treatment, was implemented. Following the diagnosis of Felty syndrome, the patient was started on treatment with oral prednisolone 40 mg/day, which effectively controlled the disease. Furthermore, there was no recurrence of severe periodontitis after the periodontal treatment.

Conclusions
Dentists and physicians should be aware that immunocompromised individuals with pancytopenia and poor oral hygiene are at risk of developing extensive periodontitis. If their susceptibility to infection and pancytopenia-related bleeding can be managed, such patients can still receive comprehensive dental treatment, including teeth extractions and periodontal therapy. Cooperation among the dentist, hematologist, and patient is necessary to improve treatment outcomes and the patient’s quality of life.
Impact of COVID-19 pandemic on the mental health of university students in the United Arab Emirates: a cross-sectional study
Authors: Vajpeyi Misra Anamika , Mamdouh Heba M. , Dani Anita , Mitchell Vivienne , Hussain Hamid Y. , Ibrahim Gamal M. , Alnakhi Wafa K. 
Published: December 2022

Abstract
Background
The COVID-19 pandemic had a significant impact on the mental well-being of students worldwide. There is a scarcity of information on the mental health impact of the COVID-19 pandemic on university students in the United Arab Emirates (UAE). This study aimed to investigate the mental health impact of the COVID-19, including depression, anxiety and resilience among a sample of university students in the UAE.

Methods
A cross-sectional study using an online survey was conducted from September to November 2021. The patient health questionnaire (PHQ-9), generalized anxiety disorder-7 (GAD-7) and Connor–Davidson Resilience Scale (CD-RISC-10) were used to assess depression, anxiety, and resilience. The COVID-19 impact was assessed using a list of questions.

Results
Only, 798 students completed the survey and were analyzed for this study. Overall, 74.8% of the students were females, 91.2% were never married, and 66.3% were UAE-nationals. Based on PHQ-9 and GAD-7 cut-off scores (≥ 10), four out of ten of the students self-reported moderate to severe depression (40.9%) and anxiety (39.1%). Significantly higher mean PHQ-9 and GAD-7 scores were found among students who were impacted by COVID-19 than those non-impacted (mean PHQ-9 = 9.51 ± 6.39 and 6.80 ± 6.34; p = 0.001, respectively) and (mean GAD-7 = 9.03 ± 6.00 and 8.54 ± 6.02; respectively, p < 0.001). Female students who were impacted by COVID-19 had statistically significant higher depression and anxiety scores (mean PHQ-9 of 9.14 ± 5.86 vs. 6.83 ± 6.25, respectively; p < 0.001) than the non-impacted females (mean GAD-7 of 9.57 ± 6.32 vs. 5.15 ± 3.88, respectively; p = 0.005). Never married students had significantly higher PHQ-9 and GAD-7 scores than ever-married (9.31 ± 6.37 vs. 6.93 ± 5.47, P = 0.003) and (8.89 ± 6.11 vs. 7.13 ± 5.49, respectively; p = 0.017).

Conclusions
The results of this study demonstrate that the COVID-19 pandemic has negatively impacted the mental health of this sample of university students in terms of depression and anxiety. The results highlight the need to adopt culturally appropriate interventions for university students and focus on vulnerable groups.
An exploration into the relationship between mineral elements (nitrogen and phosphorus) and nutritional quality in soil-watermelon (Citrullus lanatus) system
Authors: He Shan , Zhao Yuyan , Liu Chuanpeng , Li Zhenghe , Zhang Zeyu , Li Bing , Tang Xiaodan 
Published: December 2022

AbstractTo fundamentally explore the correlation between crop nutritional quality and mineral elements, specific tests and accurate analysis were carried out on all organs and root soil of watermelon (Citrullus lanatus). The results showed that the distribution patterns of nitrogen and phosphorus at watermelon maturity were similar, and the average nitrogen and phosphorus contents were in the orders of leaf and seed > stem, peel, root > pulp > root soil, and peel > seed > root, stem, leaf > root soil > pulp, respectively. From the perspective of element geochemistry, biophile and lithophile elements had the strongest correlation with nitrogen and phosphorus, and watermelon did not antagonize soil nitrogen and phosphorus uptake. The prediction model of nitrogen translocation factor in watermelon organs to total acid was established by partial least squares with R2 = 0.81. Significantly, when the isometric log-ratio of nitrogen to phosphorus in watermelon leaves was 1.97 to 2.19, the watermelon pulp showed better quality with total acid > 0.5%, total sugar > 5% and soluble solids > 10%. Therefore, the characterization of nitrogen and phosphorus in watermelon leaves can serve as a non-destructive analysis to predict watermelon fruit quality.
Ultrasensitive thrombin sensing platform based on three-way junction initiated dual signal amplification
Authors: Yang Hongxiu , Hou Lixuan , Liu Chunjing , Liu Wei , Li Lihua 
Published: December 2022

AbstractThe sensitive and precise quantitative determination of thrombin is important for both fundamental research and clinical diagnostics of hypoxic ischemic encephalopathy because it is a key biological molecule in hemostasis and hemolysis. Herein, we depict a sensitive and label-free thrombin detection approach by taking the advantages of aptamer’s superior capability to bind with thrombin and the high efficiency of three-way junction initiated dual signal recycle. In this method, a capture probe which is inserted with an aptamer sequence is designed to specifically identify thrombin molecule and facilitate the signal amplification. Based on the DNA polymerase and endonuclease Nb.BbvCI-assisted chain extension, a large amount of single-strand DNA sequences that can fold into G-quadruplex are produced to specifically recognize commercial fluorescent dye thioflavin T for signal generation. Consequently, the approach exhibits a high detection sensitivity with the limit of detection as low as 768 fM, holding a great promise for detection of thrombin and disease diagnosis in the clinic.
“Are you there?”: Teaching presence and interaction in large online literature classes
Authors: Li Fang 
Published: December 2022

AbstractIncreasing interaction in large online classes is a challenge that many teachers are facing in the post-pandemic era. This study, rooted in Garrison et al.’s CoI (Community of Inquiry) framework, employs both quantitative and qualitative methods to explore what a teacher can do in large online literature classes to promote interaction by way of enhancing teaching presence. The correlation and regression analysis of the questionnaire survey indicates that the teacher’s strategies lead to high levels of teaching, social and cognitive presence, and in turn facilitate students’ online interaction, resulting in their strong sense of satisfaction. Besides, it suggests teaching presence has stronger relationship with cognitive presence than social presence. In addition, social and cognitive presences are strong predictors for learning outcomes which account for 68% of the explained variance in this study. Students’ online interaction in the form of postings show that they are more cognitively engaged rather than socially involved, which implies that students are more focused on the construction of knowledge rather than try to be connected in the community. The limited peer interaction in spite of students’ acknowledgement that peer interaction plays a unique role in pushing them towards better understanding of the texts poses the teacher another challenge for enhancing social presence.
The bumblebee field excitations in a cosmological braneworld
Authors: Lessa L. A. , Silva J. E. G. , Almeida C. A. S. 
Published: December 2022

Abstract
We investigate the effects of the spacetime curvature and extra dimensions on the excitations of the Lorentz violating bumblebee field B

μ
. By assuming the bumblebee field living in a five-dimensional AdS
5 bulk, we found an exponential suppression of the bumblebee self-interacting constant λ and of the bumblebee vacuum expectation value (VEV) b

M
along the fifth extra dimension. The fluctuations of the bumblebee field upon the VEV can be decomposed into transverse and longitudinal modes with respect to b

M
. For a spacelike b

M
along the extra dimension and assuming a thin FRW 3-brane embedded in the AdS
5, the transverse mode is localized on the brane. The bulk geometry leads to a propagating and unbound longitudinal mode along the extra dimension. On the brane, the cosmological expansion leads to the decay of the longitudinal mode in time, as Δt ≈ H
−1.
Middle Ear Condition at the Time of Pediatric Myringotomy Tube Placement: Pain Associations Following Intraoperative Fentanyl/Ketorolac and Seasonal Variation
Authors: Cohen William G. , Zhang Bingqing , Lee David R. , Ampah Steve B. , Sobol Steven E. , Cook-Sather Scott D. 
Published: December 2022

BACKGROUND:
Ketorolac-refractory pain behavior following bilateral myringotomy and pressure equalization tube placement (BMT) is associated with the absence of middle ear fluid. Intraoperative fentanyl/ketorolac affords more reliable pain control than ketorolac alone. We hypothesized that middle ear condition would correlate with postoperative pain despite such combination therapy. We further sought to demonstrate seasonal variation in ear condition and its influence on pain.

METHODS:
We conducted a single-institution retrospective cohort study of healthy children (9 months–7 years), who underwent BMT by a single surgeon from 2015 to 2020. Anesthetic care included sevoflurane/nitrous oxide/oxygen/air by mask and intramuscular fentanyl/ketorolac. Left/right middle ear fluid status was recorded at the time of BMT, and ear condition (primary exposure) was dichotomized as bilateral infected (mucoid or purulent) or normal/unilateral infected. The primary outcome was maximum postanesthesia care unit Face, Legs, Activity, Cry, and Consolability (FLACC) score: 4–10 (moderate-to-severe pain) versus 0–3 (no-to-low pain). Rescue oxycodone, acetaminophen administration, and emergence agitation were secondary outcomes. Statistical analysis incorporated generalized linear mixed-effect models (GLMMs) with random intercepts to account for clustering by anesthesia provider. A year-over-year monthly time-series analysis was conducted using an autoregressive integrated moving average (ARIMA) regression model.

RESULTS:
Excluding recurrent cases, 1149 unique evaluable subjects remained. Bilateral infection prevalence was 39.8% (457/1149; 95% confidence interval [CI], 37.0–42.6). Probability of moderate-to-severe pain behavior was 23.5% (270/1149; 95% CI, 21.1–26.0) overall. Compared to patients with bilateral infected middle ears, those with normal/unilateral infected ears were more likely to have a FLACC score ≥4 (26.7% [185/692] versus 18.6% [85/457]; odds ratio [95% CI], 1.7 [1.2–2.3]; P = .002). Variability in pain outcome explained by the multivariable GLMM was 4.7%. Fentanyl dose response was evidenced by oxycodone administration differences (P ≤ 0.002). Moderate-to-severe pain and emergence agitation were more likely with reduced fentanyl dosing. Bilateral infection prevalence exhibited seasonality, peaking in March and nadiring in July. However, pain outcomes did not vary by season.

CONCLUSIONS:
Normal/unilateral infected ears at time of pediatric BMT are associated with higher incidence of moderate-to-severe postoperative pain following intraoperative fentanyl/ketorolac administration, but the predictive value of ear condition on pain is limited. Infections were less common in the summer.
Foxd1-dependent induction of a temporal retinal character is required for visual function
Authors: Hernández-Bejarano María , Gestri Gaia , Monfries Clinton , Tucker Lisa , Dragomir Elena I. , Bianco Isaac H. , Bovolenta Paola , Wilson Stephen W. , Cavodeassi Florencia 
Published: December 2022

ABSTRACT
Appropriate patterning of the retina during embryonic development is assumed to underlie the establishment of spatially localised specialisations that mediate the perception of specific visual features. For example, in zebrafish, an area involved in high acuity vision (HAA) is thought to be present in the ventro-temporal retina. Here, we show that the interplay of the transcription factor Rx3 with Fibroblast Growth Factor and Hedgehog signals initiates and restricts foxd1 expression to the prospective temporal retina, initiating naso-temporal regionalisation of the retina. Abrogation of Foxd1 results in the loss of temporal and expansion of nasal retinal character, and consequent absence of the HAA. These structural defects correlate with severe visual defects, as assessed in optokinetic and optomotor response assays. In contrast, optokinetic responses are unaffected in the opposite condition, in which nasal retinal character is lost at the expense of expanded temporal character. Our study indicates that the establishment of temporal retinal character during early retinal development is required for the specification of the HAA, and suggests a prominent role of the temporal retina in controlling specific visual functions.
Energy security as a research area of international security
Authors: Misiągiewicz Justyna 
Published: December 2022

Energy security is the basic analytical category for this conducted study and its findings that are included in the article. This category defines the scope and the specific character of research and its relation to security studies. It is an important element of the epistemic layer of the conducted research. On the other hand, in terms of social reality and ontology, energy security is a foreign policy objective, an international value, and a dynamic process. It concerns various types of actors: from individuals to large social groups, institutions, states, nations, and international systems. Therefore, energy security policy aims to protect the state and society against numerous threats, the multitude, unpredictability, and complexity of which result from the polyarchic international system. The research objective of the study is to analyse the essence and specificity of energy security in the light of research on international security. Thus, various theoretical approaches, useful in the analysis of energy security issues, were taken into account. Their usefulness was also determined in the case of the analysis of the specificity of the contemporary energy market. The analysis allows us to conclude that energy security issues take into account long-term development trends as well as unpredictable events related to the functioning of energy market and energy technology. Thus, unexpected, sudden phenomena resulting from the dynamics of the international environment gain in importance. The dilemma related to non-linear thinking often ignores a variety of solutions that, taken together, can cause a radical turn in the energy security concept and its evolution.
Deep Learning for Commodity Procurement: Nonlinear Data-Driven Optimization of Hedging Decisions
Authors: Busch Nicolas , Crönert Tobias , Minner Stefan , Rettinger Moritz , Sel Burakhan 
Published: December 2022

As the number of exchange-traded commodity contracts and their volatility increase, risk management through financial hedging gains importance for commodity-purchasing firms. Existing data-driven optimization approaches for hedging decisions include linear regression-based techniques. As such, they assume linear price–feature relationships and, thus, do not automatically detect nonlinear feature effects. We propose an alternative, nonlinear data-driven approach to commodity procurement based on deep learning. The prescriptive algorithm uses artificial neural networks to allow for universal approximation and requires no a priori knowledge regarding underlying price processes. We reformulate the periodic review procurement problem as a multilabel time series classification problem as the optimal bang-bang type procurement policy allows us to treat the hedging decision for each demand period as an individual subproblem that is independent of the other periods. Thereby, we are differentiating between optimal and suboptimal hedging decisions in each period and introduce a novel opportunity cost–sensitive loss function. We train maximum likelihood classifiers based on different deep learning architectures and test their performance in numerical experiments and case studies for natural gas, crude oil, nickel, and copper procurement. We show comparable performance to the state of the art for linear price–feature relationships and considerable advantages in the nonlinear case. Funding: Financial support received through the DFG as part of the AdONE GRK2201 [Grant 277991500] is gratefully acknowledged.
Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study
Authors: Amadi Casmir E. , Mbakwem Amam C. , Duro Dolapo C. , Udenze Ifeoma C. , Akinsola Clement M. , Ajuluchukwu Jayne N. , Wale Oke David A. 
Published: December 2022

Background
Simultaneous presence of elevated waist circumference and hypertriglyceridemia (HTGW) is a simple and low-cost measure of visceral obesity, and it is associated with a plethora of cardio-metabolic abnormalities that can increase the risk of cardiovascular diseases and incident Type 2 diabetes mellitus. We decided to study the prevalence, patterns, and predictors of metabolic abnormalities in Nigerian hypertensives with the HTGW phenotype.

Methods
The medical records of 582 hypertensives with complete data of interest were retrieved and analyzed for the study. Their socio-demographic data, anthropometric data, and booking blood pressure values were retrieved. The results of their fasting plasma glucose, lipid profile, uric acid and serum creatinine were also retrieved for analysis.

Results
The mean age of the study population was 56.2 ±13.6, with 53.1% being males. The prevalence of smoking and use of alcohol was 4.3% and 26.5% respectively. The prevalence of the HTGW phenotype was 23.4% and were predominantly males (61%). Subjects with the HTGW phenotype were more obese assessed by waist circumference (WC) and body mass index (BMI). Mean serum total cholesterol, triglyceride, very low-density lipoprotein, uric acid, and creatinine were significantly higher in the HTGW phenotype (p = 0.003; <0.001; <0.001; 0.002 and <0.001 respectively). The prevalence of newly diagnosed Type 2 diabetes was 28.7%. There was also a preponderance of cardio-metabolic abnormalities (obesity, dyslipidaemia, hyperuricemia) in the HTGW phenotype. In both males and females, the HGTW phenotype was significantly associated with elevated Tc, TG, VLDL, hyperuricemia and atherogenic index of plasma.

Conclusion
The HTGW phenotype is common amongst Nigerian hypertensives, and it is associated with metabolic abnormalities.
Can a knee sleeve influence ground reaction forces and knee joint power during a step-down hop in participants following anterior cruciate ligament reconstruction? A secondary analysis
Authors: Sole Gisela , Pataky Todd , Hammer Niels , Lamb Peter 
Published: December 2022

Purpose
Elastic knee sleeves are often worn following anterior cruciate ligament (ACL) reconstruction. The study aimed to define immediate and 6-week effects of wearing a knee sleeve on ground reaction forces (GRF) and knee joint power during a step-down hop task.

Methods
Using a cross-over design, we estimated GRF and knee kinematics and kinetics during a step-down hop for 30 participants following ACL reconstruction (median 16 months post-surgery) with and without wearing a knee sleeve. In a subsequent randomised clinical trial, participants in the ‘Sleeve Group’ (n = 9) wore the sleeve for 6 weeks at least 1 hour daily, while a ‘Control Group’ (n = 9) did not wear the sleeve. We compared the following outcomes using statistical parametric mapping (SPM): (1) GRF and knee joint power trajectories between three conditions at baseline (uninjured side, unsleeved injured and sleeved injured side); (2) GRF and knee joint power trajectories within-participant changes from baseline to follow-up between groups. We also compared discrete peak GRFs and power, rate of (vertical) force development, and mean knee joint power in the first 5% of stance phase.

Results
SPM showed no differences for GRF for the (unsleeved) injured compared to the uninjured sides; when wearing the sleeve, injured side mean power in the first 5% of stance increased significantly from a concentric to an eccentric power. Discrete variables showed lower peak anterior (propulsive) GRF, mean power in the first 5% of stance, peak eccentric and concentric power for the injured compared to the uninjured sides. After six weeks, a directional change for vertical GRF differed showed slightly decreased forces for the Control Group and increased forces for the Sleeve Group.

Conclusion
Wearing a knee sleeve on the anterior cruciate ligament injured knee improved knee power during the first 5% of stance during the step-down hop. No consistent changes were observed for ground reaction forces for SPM and discrete variable analyses. Wearing the knee sleeve at least one hour daily for 6-weeks lead to a directional change of increased vertical GRF for the Sleeve Group at follow-up.

Trial registration
The trial was prospectively registered with the Australia New Zealand Clinical Trials Registry No: ACTRN12618001083280, 28/06/2018. https: //anzctr.org.au/Trial/Registration/TrialReview.aspx?id=375347&isClinicalTrial=False.