bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of sagittal angle of posterior malleolus fracture on ankle joint stability：a retrospective study of 87 cases
Authors: Zhang Lei , Yang Yuening , Su Fan , Peng Xiaoyao , Xiong Jixiang , Sun Xinghao , Xia Zhangrong , Wu Duolu , Chen Hongren , Xiong Bin , Wang Guoyou 
Published: March 2022

Abstract
BackgroundPrevious studies have studied more factors on the ankle stability of the posterior ankle fracture, which is related to a stereostructure of the fracture fragment. Previous studies have shown that the ankle stability may be affected by the sagittal surface of the fracture block, with less research in this field. The aim of this study was to explore the influence of the sagittal angle(SA) on ankle joint stability by scanning and reconstructing three types of posterior malleolus fractures(PMFs) with different sagittal angle (SA).MethodsThe CT data of 87 patients with PMFs were collected retrospectively and reconstructed. PMFs were divided into three types: posterolateral-oblique type (type I), medial-extension type (type II) and small-shell type (type III).The collected sagittal angle data were statistically analyzed with the posterior fragment area, fragment area ratio (FAR), fragment transverse diameter ratio (FWR), fragment length ratio (FLR), fragment height (FH), and contact area (CA).Results(1)SA was positively correlated with posterior fragment area(r = 0.804,P < 0.01),with regression equation s = 0.085*SA + 0.34;(2)SA was positively correlated with FAR(r = 0.392,P < 0.01),with regression equation FAR = 0.004*SA + 0.092;(3)SA was positively correlated with FWR(r = 0.261,P < 0.05), with regression equation FWR = 0.03*SA + 0.4624;(4)SA was positively correlated with FLR(r = 0.481,P < 0.01), with regression equation FLR = 0.05*SA + 0.209;(5) SA was positively correlated with CA (r = 0.474, P < 0.01),with regression equation CA = 7.942*SA + 160.866;(6)SA was positively correlated with FH(r = 0.474,P < 0.01), with regression equation FH = 0.046*SA + 1.406.ConclusionThe sagittal angle was positively correlated with posterolateral-oblique type (type I) of Posterior malleolus fractures, and SA could be considered to reflect the ankle joint stability of PMFs.Level of evidence: Level III, retrospective comparative study.
The Effect of Strategy Performance Management Methods on Employee Wellbeing: A Case Study Analyzing the Effects of Balanced Scorecard
Authors: CIGNITAS CEREN PERI , Arevalo Juan Antonio Torrents , Crusells Jordi Vilajosana 
Published: March 2022

Abstract
The study investigates the effect of the Balanced Scorecard, one of the performance measurement systems, on employee well-being (EWB) in organizations. As a result of the literature research, it is seen that employee welfare is examined in 3 different areas: Job Satisfaction, Organizational Commitment, and Job Engagement. One of the most important factors for the success of an organization is the happy employees who contribute tremendously to the improvement of the organization's performance. Both qualitative and quantitative measurement methods were used for this study. The surveys that have used for this study included 27334 employees in the state of Michigan and the surveys data were analyzed by Statistical Package for Social Sciences (SPSS) 28. The study revealed that the BSC strategies implemented in the State of Michigan improved organizational performance in the four perspectives of financial, customer, internal process, and learning & growth. The statistical results of employee satisfaction surveys show that BSC increases job satisfaction by 68.30% (R-squared: 0.683), work engagement by 71.00% (R-squared: 0.710), and organizational commitment by 21.30% (R-squared: 0.213). With the BSC strategy and learning-growth perspective that has been in effect for 20 years, employee satisfaction has been increased, organizational commitment and job engagement have been prioritized in the State of Michigan. The result of this study will help leaders and HR departments measure and increase employee well-being with performance measurement tools.
The Impact of Brain Lesion Characteristics and the Corticospinal Tract Wiring on Mirror Movements in Unilateral Cerebral Palsy
Authors: Simon-Martinez Cristina , Decraene Lisa , Zielinski Ingar , Hoare Brian , Williams Jacqueline , Mailleux Lisa , Steenbergen Bert , Ortibus Els , Feys Hilde , Klingels Katrijn 
Published: March 2022

Abstract
Background. Mirror movements (MM) influence bimanual performance in children with unilateral cerebral palsy (uCP). Whilst MM are related to brain lesion characteristics and the corticospinal tract (CST) wiring pattern, the combined impact of these neurological factors remains unknown.Methods. Forty-nine children with uCP (mean age 10y6mo) performed a repetitive squeezing task to quantify similarity (MM-similarity) and strength (MM-intensity) of the MM activity. We used MRI data to evaluate lesion type (periventricular white matter, N=30; cortico-subcortical, N=19), extent of ipsilesional damage, presence of bilateral lesions, and damage to basal ganglia, thalamus and corpus callosum. The CST wiring was assessed with Transcranial Magnetic Stimulation (17 CSTcontralateral, 16 CSTipsilateral, 16 CSTbilateral). Data was analyzed with regression analyses. Results. In the more-affected hand, MM-similarity was higher with more damage to the corpus callosum. MM-intensity was higher in children with a CSTcontralateral wiring pattern with damage to the basal ganglia and thalamus. In the less-affected hand, MM-similarity was related with the interaction between lesion type and CST wiring pattern, with higher MM-similarity in children with cortico-subcortical lesions in the CSTcontralateral group. MM-intensity was higher with larger damage to the corpus callosum and unilateral lesions. Conclusions. A complex combination of neurological factors influences MM characteristics, and the mechanisms differ between hands.
Impact of initial explants on in vitro propagation of native potato (Solanum tuberosum, Andigena group)
Authors: Mora Lenny Yojana Correa , Tarazona Daicy Yaneth Galvis , Quintero Maria de los Angeles Bohórquez , Barrera Eyda Johanna Araque , Ruíz Johan Sebastian Urquijo , Moreno Diana Marcela Arias , Pérez Zaida Zarely Ojeda 
Published: March 2022

Abstract
The high nutritional potential of native potatoes makes them an invaluable genetic resource for breeding. However, pathogens have caused both yield and industrial quality losses, and plant tissue culture is a promising alternative to obtain clean plant material. We compared distinct segments excised from apical and lateral sprouts taken from tubers as initial explants for in vitro culture of sixteen native potato genotypes. Thus, apical-distal (AD), mid-apical (MA), lateral-distal (LD), and mid-lateral (ML) segments were all grown on Murashige & Skoog (MS) medium. These explants were aseptic, reactive, and viable for all genotypes (with a probability greater than 30%), yielding cumulative proliferation rates of up to 1:10 individualizable segments, and about 86% of in vitro plants with 2 to 11 roots of up to 117 mm long. Responses were genotype-dependent during all stages of cultivation, and the best responding genotypes were Maravillosa, Duraznillo and Pepina Rodeo. On the other hand, AD sprouts were the best sprout type and segment for in vitro establishment, regardless of genotype. This is the first study of its kind with such a large range of Andean potato genotypes and should contribute to their germplasm conservation and increased multiplication efficiency.
Predictive value of peripheral neutrophil count on admission for in- hospital adverse events in young patients with acute coronary syndrome
Authors: Li Tingting , Zang Xiwen , Liu Xiangchun , Li Qi , Li Zhuqing , Yin Xuemei , Lu Chengzhi 
Published: March 2022

Abstract
Background: In recent years, the incidence of acute coronary syndrome (ACS) in young people has been increasing gradually. Although the reperfusion strategy has improved the therapeutic effect, the prognosis of ACS is still not satisfactory.The relationship between neutrophil level and cardiovascular adverse events and left heart function during hospitalization in young patients with ACS has been rarely reported. This study explored the relationship between neutrophil count at admission and in-hospital major adverse cardiac and cerebrovascular events ( MACEE ) and left ventricular ejection fraction ( LVEF ) in young ACS.Methods：This study included 207 young ACS patients (＜45 years old) who underwent coronary angiography. According to the median neutrophil count at admission, the patients were divided into two groups. The relationship between neutrophil count and MACEE and LVEF during hospitalization was analyzed by univariate and multivariate regression, and receiver operating characteristic (ROC)curve analysis was adopted.Results：Neutrophil count was an independent risk factor of in-hospital MACEE (OR: 1.446, 95% CI: 1.136-1.842, P = 0.003) and LVEF＜50%(OR: 1.381, 95% CI: 1.117–1.708, P = 0.003).The cutoff value of neutrophil count for predicting the occurrence of in-hospital MACEE was 6.94*10^9/L with a sensitivity of 93% and specificity of 54% (AUC: 0.798,95% CI: 0.714-0.881, P < 0.001), and for identifying the LVEF＜50% was 8.36*10^9/L with a sensitivity of 70% and specificity of 76% (AUC: 0.748, 95% CI: 0.648-0.848, P < 0.001).Conclusion：Peripheral blood neutrophil count at admission is an independent predictor of MACEE and LVEF in young ACS patients during hospitalization, providing important information for predicting the poor prognosis of young ACS patients.
Prognostic Value of LDHD and Its Correlation With Immune Infiltrates in Thyroid Cancer
Authors: Tang Weiqiang , Chen Zuyao , Liao Yajie , Fang Yuan , Xia Min , Zu Xuyu , Wen Gebo , Zhong Jing 
Published: March 2022

Abstract
Background: LDHD is a subtype of the LDH family that can participate in D-lactate metabolism. However, the expression of LDHD in tumors and its role in tumor immunity currently unknown. The objective of this research was to estimate the expression and prognosis of LDHD in pan-cancer, and to explore the communication between LDHD expression level and tumor immune infiltration.Methods: LDHD expression level in pan-cancer was explored by TIMER and UALCAN databases and the prognostic value of LDHD was explored by Kaplan Meier plotter and PrognoScan databases. Then, the correlation between LDHD expression level and immune cell infiltration was evaluated by TIMER database. In addition, the relationship between LDHD expression and clinical features of THCA was verified in TCGA database. Results: The expression of LDHD mRNA or protein is downregulated in varied tumor types, and LDHD expression level is significantly related to the prognosis in tumors. Moreover, the downregulation of LDHD was found related to increased immune-cell infiltration and worse clinical features, especially in thyroid cancer.Conclusion: LDHD may be a potential pan-cancer prognostic biomarker. In thyroid cancer, loss of expression of LDHD may mediate tumor initiation and progression by affecting immune cell infiltration.
BCG revaccination qualitatively and quantitatively enhances SARS-CoV-2 spike-specific neutralizing antibody and T cell responses induced by the COVISHIELDTM vaccine in SARS-CoV-2 seronegative young Indian adults
Authors: Rakshit Srabanti , Adiga Vasista , Ahmed Asma , Parthiban Chaitra , Kumar Nirutha , Shivalingaiah Sudarshan , Rao Srishti , D'Souza George , Dwarkanath Pratibha , Dias Mary , Maguire Thomas , Doores Katie , Dasgupta Prokar , Babji Sudhir , Ottenhoff Tom , Stuart Kenneth , De Rosa Stephen , McElrath M. Juliana , Vyakarnam Annapurna 
Published: March 2022

Abstract
This study tested if prior BCG revaccination can further boost immune responses subsequently induced by an otherwise efficacious Oxford/AstraZeneca ChAdOx1nCoV-19 vaccine, referred to as COVISHIELDTM in India. We compared COVISHIELDTM induced longitudinal immune responses in 21 BCG re-vaccinees (BCG-RV) and 13 BCG-non-revaccinees (BCG-NRV), all of whom were BCG vaccinated at birth and latent tuberculosis negative, after COVISHIELDTM prime and boost with baseline samples that were collected pre-pandemic and pre-BCG revaccination. Compared to BCG-NRV, BCG-RV displayed significantly higher magnitude of spike-specific Ab and T cell responses, including a greater proportion of high responders; better quality polyfunctional CD4 and CD8 T cells that persisted and a more robust Ab and T cell response to the Delta mutant of SARS-CoV-2 highlighting greater breadth. Mechanistically, BCG adjuvant effects on COVISHIELDTM induced adaptive responses was associated with more robust innate responses to pathogen-associated-molecular-patterns through TNF-α and IL-1β secretion. This study highlights the potential of using a cheap and globally available vaccine as an adjuvant to enhance heterologous adaptive immune responses induced by COVIDSHIELDTM and other emerging vaccines.
Syndemic analysis of the pandemic Covid-19 crisis: A multidisciplinary “Understand - Anticipate – Propose” meta-method
Authors: Lepelletier Didier , Souhard Camille , Chidiac Christian , Chauvin Franck , Mansour Zeina 
Published: March 2022

Abstract
Background. In order to understand the pandemic COVID-19 crisis in a forward-looking way, the French High Council for public health (HCSP) has designed a conceptual scheme for public health planning based on L. Green's model in order to better understand the issues at stake, by identifying dangers and levers for action. The final aim was to establish priorities and guidelines in order to anticipate the collateral consequences of the management of the crisis and be better prepared for the next one. Method. A public health conceptual framework PROCEED-PRECCED adapted to the Covid-19 health crisis was developed using both a graphic (concept map) and analytic (to make the conceptual scheme functional) approaches. Then, a "meta-method" was applied using three distinct cognitive stages: understanding, anticipation and proposals of action.Results. The conceptual framework was broken down into 10 technical sheets covering essential diagnoses and integrating different public health determinants. Each of these was broken down into three cognitive stages, allowing for a diagnosis of understanding, a scenario of anticipation and a strategic analysis of action according to the chronology: understand-anticipate-propose. From these 10 technical sheets, 32 guidelines have been proposed.Conclusion. This work is intended to allow reflections on public health approaches to strengthen and anticipate health crisis management and health planning by politic managers working at national or sub-national level.
Application Value of BALF mNGS for Screening Patients With Mycobacterium Tuberculosis Infection in General Hospitals
Authors: Wang Yafei , Zhou Ying , Cao Xing , Li Xueying , Ye Shenglan 
Published: March 2022

Abstract
BackgroundTo evaluate the diagnostic value of metagenomic next-generation sequencing (mNGS) in patients with Mycobacterium tuberculosis infection.MethodsPatients hospitalized for pneumonia in the Department of Pulmonary and Critical Care Medicine of Wuhan Central Hospital from January to June 2021 were enrolled in the study. Patients were examined by mNGS and divided into two groups according to the M. tuberculosis infection. We compared the clinical indicators of infected patients of both groups. All patients in the M. tuberculosis infection group underwent bronchoalveolar lavage (BAL). Different detection methods were used to detect pathogenic bacteria. ResultsA total of 111 patients agreed to undergo mNGS. Of these, 15 were eventually enrolled in the study group. We found that patients with decreased white blood cells had a higher risk of infection with M. tuberculosis than those infected with other pathogens (OR=0.807, 95%CI: 0.672–0.969, P=0.022). We also found that mNGS had a higher positive rate of M. tuberculosis infection detection than traditional detection methods. The positive detection rates of TB-DNA-PCR, Xpert MTB, and T-SPOT. TB were 69.23%, 83.33%, 77.77%, respectively.ConclusionsBALF mNGS assay could quickly and effectively detect M. tuberculosis complex in patients with pulmonary infection in a general hospital setting.
Urinary Stable Nitrogen Isotopes Ratios Are Responsive to Controlled Short-Term Calorie Restriction
Authors: Wasserfurth Paulina , Huelsemann Frank , Koehler Karsten 
Published: March 2022

Abstract
Purpose
Increased nitrogen losses observed during periods of energy deficiency are attributed to increased breakdown of endogenous proteins. Stable nitrogen isotope ratios (δ15N) measured in human hair have previously been shown to reflect prolonged periods of increased protein breakdown. The goal of this study was to determine whether stable nitrogen isotopes measured from urinary urea (δ15Nurea) represent a potential biomarker of more immediate changes in endogenous protein utilization.
Methods
We analyzed samples from recreationally active males (n = 6, 25.2 ± 1.0 years, BMI: 23.5 ± 0.6 kg/m2) who took part in a repeated measures cross-over study during which they underwent 4 days of calorie restriction (~ 15 kcal/kg FFM) without and with exercise (CR-EX, CR + EX) and two control conditions in energy balance (CON-EX, CON + EX). δ15Nurea was analyzed from urine samples. In addition, the trophic shift (Δ15N) was calculated as δ15Nurea - δ15Ndiet, with δ15Ndiet obtained from food logs.
Results
δ15Nurea was significantly elevated in CR-EX (4.35 ± 0.16‰) when compared to CR + EX (3.84 ± 0.14‰; p = 0.050, d = 1.56), CON-EX (3.65 ± 0.09‰; p = 0.026, d = 1.63) and CON + EX (3.34 ± 0.13‰, p = 0.001, d = 3.52). δ15Nurea was also significantly higher in CR + EX when compared to CON + EX (p = 0.050, d = 1.5). Δ15N was positive in CR-EX (0.24 ± 0.15‰) and negative in all other conditions (CR + EX: -0.55 ± 0.46‰; CON-EX: -0.96 ± 0.19; CON + EX: -1.1 ± 0.15). CR-EX differed significantly from CON-EX (p = 0.005, d = 2.55) and CON + EX (p = 0.006, d = 2.3).
Conclusion
Results from this analysis suggest that δ15Nurea as well as Δ15N can serve as alternative tools to monitor changes in endogenous protein turnover during phases of calorie restriction.
Knowledge and experience of physicians during the COVID-19 Pandemic: A global cross-sectional study
Authors: Mansour Rania , Rallapalli Smrithi , Baidwan Hamreet Kaur , Razai Mohammad S , Abou-Abbas Linda 
Published: March 2022

Abstract
Physicians are on the frontline of the COVID-19 pandemic with responsibility to manage the disease. The aim of this study is to investigate physicians’ knowledge, attitudes, and preventative practices regarding the COVID-19 pandemic and COVID-19 vaccinations, as well as explore physicians’ recommendations for future pandemics. A mixed-methods online survey was disseminated to physicians globally. The survey was distributed via social media from August 9–30, 2021. Data collected included sociodemographic characteristics, knowledge, attitudes, and practices towards COVID-19, concerns regarding vaccinations, and perspectives on policies implemented. Descriptive statistics were reported, and qualitative data were analysed using inductive thematic analysis. A total of 399 physicians from 62 countries completed the survey, with similar participation from High Income Countries and Low- or Middle-Income Countries. Most physicians (87%) revealed a good level of knowledge while only half (54%) reported adhering to adequate preventative measures. More than half of participants (56%) indicated that the policies implemented to handle COVID-19 by their public health agencies were insufficient or disorganised. While most physicians reported increased mental stress (61%) and described their experience with COVID-19 using negative terminology (63%), the majority of physicians (87%) indicated they are willing to continue working in healthcare. Physicians globally possessed good knowledge of COVID-19 and vaccinations; yet improvements in ensuring compliance with preventative practices is warranted. Findings from this study have important implications. As recommended by physicians, efforts to manage pandemics should involve (1) strengthening health systems, (2) minimising adverse effects of infodemics, (3) delegating decision-making roles appropriately, and (4) acknowledging global responsibility.
Left Ventricular End Diastolic Loading: Comparison of Cardiac MR with Echocardiography
Authors: Rumer Christopher , Qiao Erica , Linker David , Dubinsky Theodore 
Published: March 2022

Abstract
PurposeIn a prior publication, loss of myocardial bounce was highly associated with systolic and diastolic dysfunction. The bounce is the rapid change in LV volume at the end of diastole during atrial contraction just prior to systolic ejection. This study attempts to determine if bounce is associated with diastolic dysfunction determined by echocardiography.Methods135 patients with an echocardiogram and a cardiac MR were selected with 38% of those paired of studies within three months of each other. The bounce was graded by 3 blinded observers into categories of 0=none, 1=minimal/reduced, and 2=normal bounce.ResultsInter-reader agreement was summarized using the intraclass correlation coefficient (ICC) and ratings was moderate [ICC 0.60, 95% confidence interval (0.51-0.68)]. The sensitivity and specificity of lack of bounce (grade 0 or 1) as a screen for diastolic dysfunction on echo were 89% and 47%, respectively.ConclusionThe simple observation of a normal myocardial bounce in MRs was predictive of normal diastolic function and lack of was highly associated with dysfunction determined via echocardiography. Systolic function remains normal in some of these patients and this finding may represent diastolic dysfunction. Further studies examining the relationship between bounce with different types of diastolic function is needed. This updated study confirms myocardial bounce seen on various cardiac imaging modalities may be a simple useful tool for detecting cardiac dysfunction.
Identifying effective sink node combinations in spacecraft data transfer networks
Authors: Clark Ruaridh , McGrath Ciara Nora , Macdonald Malcolm 
Published: March 2022

Abstract
Complex networks are emerging in low-Earth-orbit as the communication architectures of inter-linked space systems. These data transfer networks vary based on spacecraft interaction with targets and ground stations, which respectively represent source and sink nodes for data flowing through the network. We demonstrate how networks can be used to identify effective sink node selections that, in combination, provide source coverage, high data throughput, and low latency connections for intermittently connected, store-and-forward space systems. The challenge in this work is to account for the changing data transfer network that varies significantly depending on the ground stations selected -- given a system where data is downlinked by spacecraft at the first opportunity. Therefore, passed-on networks are created to capture the redistribution of data following a sink node's removal from the system, a problem of relevance to traffic management in a variety of flow network applications. Modelling the system using consensus dynamics, enables sink node selections to be evaluated in terms of their source coverage and data throughput. While restrictions in the depth of propagation when defining passed-on networks, ensures the optimisation implicitly rewards lower latency connections. This is a beneficial by-product for both space system design and store-and-forward data networks in general.The passed-on networks also provide an insight into the relationship between sink nodes, with eigenvector embedding-based communities identifying sink node divisions that correspond with differences in source node coverage.