bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon Isotope Effects in Relation to CO2 Assimilation by Tree Canopies
Authors: Cernusak Lucas A. , Ubierna Nerea 
Published: June 2022

AbstractThe carbon atoms deposited in tree rings originate from the CO2 in the atmosphere to which the tree’s canopy is exposed. Thus, the first control on the stable carbon-isotope composition of tree rings is by δ13C of atmospheric CO2. There has been an inter-annual trend of decreasing δ13C of atmospheric CO2 over the past two centuries as a result of combustion of fossil fuels and land-use change. Atmospheric CO2 is, for the most part, well mixed, but the sub-canopy air space can become depleted in 13C due to inputs from soil and plant respiration when turbulent exchange with the troposphere is hindered, for example by a high leaf area index at night. This is less likely to occur during daytime when turbulence is higher and photosynthesis takes place. Discrimination against 13C (∆13C) occurs upon assimilation of atmospheric CO2 by C3 photosynthesis. Trees using the C3 photosynthetic pathway comprise the overwhelming majority of all trees. The primary control on the extent of discrimination during C3 photosynthesis is the drawdown in CO2 concentration from the air outside the leaf to the site of carboxylation in the chloroplast. Part of this drawdown is captured by ci/ca, that is, the ratio of intercellular to ambient CO2 concentrations. The ci/ca represents the balance between the CO2 supply by stomata and its demand by photosynthesis. It can be related to water-use efficiency, the amount of CO2 taken up by photosynthesis for a given amount of water loss to the atmosphere, assuming a given evaporative demand. To predict time-averaged ci/ca from wood ∆13C, a simplified, linear model can be employed. In this linear model, the slope is determined by $$\overline{b }$$

b

¯

, the effective enzymatic discrimination. The value of $$\overline{b }$$

b

¯

can be estimated by comparing wood ∆13C to representative measurements of ci/ca. The $$\overline{b }$$

b

¯

was originally estimated from observations of leaf tissue to have a value of 27‰. We compiled data for woody stem tissue here, and our analysis suggests that a lower $$\overline{b }$$

b

¯

should be used in the simplified model for wood ($$\overline{b }$$

b

¯

= 25.5‰) than for leaves ($$\overline{b }$$

b

¯

= 27‰). This is also consistent with widespread observations that woody tissues are enriched in 13C compared to leaves.
Mapping
Authors: Modica Marcello 
Published: June 2022

AbstractThe first scale of analysis sets to outline a comprehensive and actual overview of Alpine brownfields. To this purpose, a territorial census of existing and potentially future sites is developed, integrated by a qualitative stakeholder survey addressed to national, regional and local planning institutions in brownfield-affected contexts. The emerging brownfield geography provides a first ever transnational and concrete insight on the territorial incidence of industrial decline in the Alpine macro-region, while also suggesting how to interpret the challenge of redevelopment across the different regional contexts and local situations.
SETD2: from chromatin modifier to multipronged regulator of the genome and beyond
Authors: Molenaar Thom M. , van Leeuwen Fred 
Published: June 2022

AbstractHistone modifying enzymes play critical roles in many key cellular processes and are appealing proteins for targeting by small molecules in disease. However, while the functions of histone modifying enzymes are often linked to epigenetic regulation of the genome, an emerging theme is that these enzymes often also act by non-catalytic and/or non-epigenetic mechanisms. SETD2 (Set2 in yeast) is best known for associating with the transcription machinery and methylating histone H3 on lysine 36 (H3K36) during transcription. This well-characterized molecular function of SETD2 plays a role in fine-tuning transcription, maintaining chromatin integrity, and mRNA processing. Here we give an overview of the various molecular functions and mechanisms of regulation of H3K36 methylation by Set2/SETD2. These fundamental insights are important to understand SETD2’s role in disease, most notably in cancer in which SETD2 is frequently inactivated. SETD2 also methylates non-histone substrates such as α-tubulin which may promote genome stability and contribute to the tumor-suppressor function of SETD2. Thus, to understand its role in disease, it is important to understand and dissect the multiple roles of SETD2 within the cell. In this review we discuss how histone methylation by Set2/SETD2 has led the way in connecting histone modifications in active regions of the genome to chromatin functions and how SETD2 is leading the way to showing that we also have to look beyond histones to truly understand the physiological role of an ‘epigenetic’ writer enzyme in normal cells and in disease.
Therapeutic value of tafamidis in patients with wild-type transthyretin amyloidosis (ATTRwt) with cardiomyopathy based on cardiovascular magnetic resonance (CMR) imaging
Authors: Chamling Bishwas , Bietenbeck Michael , Korthals Dennis , Drakos Stefanos , Vehof Volker , Stalling Philipp , Meier Claudia , Yilmaz Ali 
Published: June 2022

Abstract
Objectives
The purpose of this study was to carefully analyse the therapeutic benefit of tafamidis in patients with wild-type transthyretin amyloidosis (ATTRwt) and cardiomyopathy (ATTRwt-CM) after one year of therapy based on serial multi-parametric cardiovascular magnetic resonance (CMR) imaging.

Background
Non-sponsored data based on multi-parametric CMR regarding the effect of tafamidis on the cardiac phenotype of patients with ATTRwt-CM are not available so far.

Methods
The present study comprised N = 40 patients with ATTRwt-CM who underwent two serial multi-parametric CMR studies within a follow-up period of 12 ± 3 months. Baseline (BL) clinical parameters, serum biomarkers and CMR findings were compared to follow-up (FU) values in patients treated “with” tafamidis 61 mg daily (n = 20, group A) and those “without” tafamidis therapy (n = 20, group B). CMR studies were performed on a 1.5-T system and comprised cine-imaging, pre- and post-contrast T1-mapping and additional calculation of extracellular volume fraction (ECV) values.

Results
While left ventricular ejection fraction (LV-EF), left ventricular mass index (LVMi), left ventricular wall thickness (LVWT), native T1- and ECV values remained unchanged in the tafamidis group A, a slight reduction in LV-EF (p = 0.003) as well as a subtle increase in LVMi (p = 0.034), in LVWT (p = 0.001), in native T1- (p = 0.038) and ECV-values (p = 0.017) were observed in the untreated group B. Serum NT-proBNP levels showed an overall increase in both groups, however, with the untreated group B showing a relatively higher increase compared to the treated group A. Assessment of NYHA class did not result in significant intra-group differences when BL were compared with FU, but a trend to improvement in the treated group A compared to a worsening trend in the untreated group B (∆p = 0.005).

Conclusion
As expected, tafamidis does not improve cardiac phenotype in patients with ATTRwt-CM after one year of therapy. However, tafamidis seems to slow down cardiac disease progression in patients with ATTRwt-CM compared to those without tafamidis therapy based on multi-parametric CMR data already after one year of therapy.
Minimally invasive mesohepatectomy for centrally located liver lesions—a case series
Authors: Birgin Emrullah , Hartwig Vanessa , Rasbach Erik , Seyfried Steffen , Rahbari Mohammad , Reeg Alina , Jentschura Sina-Luisa , Téoule Patrick , Reißfelder Christoph , Rahbari Nuh N. 
Published: June 2022

Abstract
Background
Resection of centrally located liver lesions remains a technically demanding procedure. To date, there are limited data on the effectiveness and safety of minimally invasive mesohepatectomy for benign and malignant lesions. It was therefore the objective of this study to evaluate the perioperative outcomes of minimally invasive mesohepatectomy for liver tumors at a tertiary care hospital.

Methods
Consecutive patients who underwent a minimally invasive anatomic mesohepatectomy using a Glissonean pedicle approach from April 2018 to November 2021 were identified from a prospective database. Demographics, operative details, and postoperative outcomes were analyzed using descriptive statistics for continuous and categorical variables.

Results
A total of ten patients were included, of whom five patients had hepatocellular carcinoma, one patient had cholangiocarcinoma, three patients had colorectal liver metastases, and one patient had a hydatid cyst. Two and eight patients underwent robotic-assisted and laparoscopic resections, respectively. The median operative time was 393 min (interquartile range (IQR) 298–573 min). Conversion to laparotomy was required in one case. The median lesion size was 60 mm and all cases had negative resection margins on final histopathological analysis. The median total blood loss was 550 ml (IQR 413–850 ml). One patient had a grade III complication. The median length of stay was 7 days (IQR 5–12 days). Time-to-functional recovery was achieved after a median of 2 days (IQR 1–4 days). There were no readmissions within 90 days after surgery.

Conclusion
Minimally invasive mesohepatectomy is a feasible and safe approach in selected patients with benign and malignant liver lesions.
Brain Reactions to Opening and Closing the Eyes: Salivary Cortisol and Functional Connectivity
Authors: Chang Shen-Da , Kuo Po-Chih , Zilles Karl , Duong Tim Q. , Eickhoff Simon B. , Huang Andrew C. W. , Tsai Arthur C. , Cheng Philip E. , Liou Michelle 
Published: June 2022

AbstractThis study empirically assessed the strength and duration of short-term effects induced by brain reactions to closing/opening the eyes on a few well-known resting-state networks. We also examined the association between these reactions and subjects’ cortisol levels. A total of 55 young adults underwent 8-min resting-state fMRI (rs-fMRI) scans under 4-min eyes-closed and 4-min eyes-open conditions. Saliva samples were collected from 25 of the 55 subjects before and after the fMRI sessions and assayed for cortisol levels. Our empirical results indicate that when the subjects were relaxed with their eyes closed, the effect of opening the eyes on conventional resting-state networks (e.g., default-mode, frontal-parietal, and saliency networks) lasted for roughly 60-s, during which we observed a short-term increase in activity in rs-fMRI time courses. Moreover, brain reactions to opening the eyes had a pronounced effect on time courses in the temporo-parietal lobes and limbic structures, both of which presented a prolonged decrease in activity. After controlling for demographic factors, we observed a significantly positive correlation between pre-scan cortisol levels and connectivity in the limbic structures under both conditions. Under the eyes-closed condition, the temporo-parietal lobes presented significant connectivity to limbic structures and a significantly positive correlation with pre-scan cortisol levels. Future research on rs-fMRI could consider the eyes-closed condition when probing resting-state connectivity and its neuroendocrine correlates, such as cortisol levels. It also appears that abrupt instructions to open the eyes while the subject is resting quietly with eyes closed could be used to probe brain reactivity to aversive stimuli in the ventral hippocampus and other limbic structures.
Detecting latent topics and trends in blended learning using LDA topic modeling
Authors: Yin Bin , Yuan Chih-Hung 
Published: June 2022

AbstractWith the rapid application of blended learning around the world, a large amount of literature has been accumulated. The analysis of the main research topics and development trends based on a large amount of literature is of great significance. To address this issue, this paper collected abstracts from 3772 eligible papers published between 2003 and 2021 from the Web of Science core collection. Through LDA topic modeling, abstract text content was analyzed, then 7 well-defined research topics were obtained. According to the topic development trends analysis results, the emphasis of topic research shifted from the initial courses about health, medicine, nursing, chemistry and mathematics to learning key elements such as learning outcomes, teacher factors, and presences. Among 7 research topics, the popularity of presences increased significantly, while formative assessment was a rare topic requiring careful intervention. The other five topics had no significant increase or decrease trends, but still accounted for a considerable proportion. Through word cloud analysis technology, the keyword characteristics of each stage and research focus changes of research were obtained. This study provides useful insights and implications for blended learning related research.
Genetic variation and QTL analysis of saturated fatty acids in two doubled haploid populations of oilseed rape (Brassica napus L.)
Authors: Yusuf Abdusaheed Olabisi , Richter Jan-Christoph , Möllers Christian 
Published: June 2022

AbstractConsumption of foodstuff with low contents of saturated fatty acids is considered beneficial for human health. Reducing saturated fatty acid content in oilseed rape (canola) and other oil and protein crops is a relevant breeding aim. The objective of this work was to study the genetic variation and inheritance of saturated fatty acids in two DH populations of oilseed rape, to map QTL and to identify candidate genes. In addition, the correlation to other seed quality traits was studied. To this end, two half-sib DH populations were tested in up to five field environments in north-western Europe and seeds harvested from open-pollinated seeds were analyzed. Genotyping was performed using Illumina Brassica 15 K SNP chip. In both populations, significant effects for the genotypes and for the environments were detected, and heritability ranged from 68 to 89% for the predominant palmitic acid and stearic acid content. Up to 48 QTL for different fatty acids, oil and acid detergent lignin (ADL) content were mapped in the two populations. Co-locating QTL for palmitic acid, stearic acid, the C16/18 fatty acid ratio, the FATB/A ratio, oil and ADL content were identified on different chromosomes. A large number of candidate genes were identified within the vicinity of QTL flanking markers. Identification of several co-locating QTL positions, of associated candidate genes and SNP markers should facilitate oilseed rape breeding for low saturated fatty acid content.
Derivation from Bloch Equation to von Neumann Equation to Schrödinger–Pauli Equation
Authors: Wang Lihong V. 
Published: June 2022

AbstractThe transition from classical physics to quantum mechanics has been mysterious. Here, we mathematically derive the space-independent von Neumann equation for electron spin from the classical Bloch equation. Subsequently, the space-independent Schrödinger–Pauli equation is derived in both the quantum mechanical and recently developed co-quantum dynamic frameworks.
Bacterial Species Associated with Highly Allergenic Plant Pollen Yield a High Level of Endotoxins and Induce Chemokine and Cytokine Release from Human A549 Cells
Authors: Ambika Manirajan Binoy , Hinrichs Ann-Kathrin , Ratering Stefan , Rusch Volker , Schwiertz Andreas , Geissler-Plaum Rita , Eichner Gerrit , Cardinale Massimiliano , Kuntz Sabine , Schnell Sylvia 
Published: June 2022

AbstractSensitization to pollen allergens has been increasing in Europe every year. Most studies in this field are related to climate change, phenology, allergens associated with different pollens, and allergic disorders. As a plant microhabitat, pollen is colonized by diverse microorganisms, including endotoxin-producing bacteria which may contribute to pollen allergy (pollinosis). Therefore, bacteria isolated from high allergenic and low allergenic plant pollen, as well as the pollen itself with all microbial inhabitants, were used to assess the effect of the pollen by measuring the endotoxins lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations and their effect on chemokine and cytokine release from transwell cultured epithelial A549 cells as a model of epithelial lung barrier. High allergenic pollen showed a significantly higher level of bacterial endotoxins; interestingly, the endotoxin level found in the bacterial isolates from high allergenic pollen was significantly higher compared to that of bacteria from low allergenic pollen. Moreover, bacterial LPS concentrations across different pollen species positively correlated with the LPS concentration across their corresponding bacterial isolates. Selected bacterial isolates from hazel pollen (HA5, HA13, and HA7) co-cultured with A549 cells induced a potent concentration-dependent release of the chemokine interleukin-8 and monocyte chemotactic protein-1 as well as the cytokine TNF-alpha and interleukin-2 to both apical and basal compartments of the transwell model. This study clearly shows the role of bacteria and bacterial endotoxins in the pollen allergy as well as seasonal allergic rhinitis.
Viscoelastic Characterization and Degradation Stability Investigation of Poly(butylene-adipate-co-terephthalate) – Calcium-Phosphate Glass Composites
Authors: Togliatti Elena , Milanese Daniel , Pugliese Diego , Sciancalepore Corrado 
Published: June 2022

AbstractIn this work new biodegradable composite materials based on poly(butylene-adipate-co-terephthalate) (PBAT) reinforced with water-soluble calcium-phosphate glass (CPG) microparticles at different filler concentration (0, 4, 10, 20 and 40 wt%) were characterized by dynamic-mechanical analysis (DMA), aging and fragmentation tests. DMA results showed increasing storage modulus (E′) values with the filler content, without a significant modification of the glass transition temperature (Tg), translating in a reinforcing effect of the filler particles with good interphase adhesion. The creep compliance decreased with the increase of the CPG content, confirming a greater resistance of the composites to deformation under constant stress. The stability to weathering agents and the degree of fragmentation in laboratory-scale composting conditions were also tested, obtaining a higher sensitivity to degradation of the PBAT-based composites with the increase of CPG content. Overall, the addition of CPG particles in a PBAT matrix produced stiffer composites, with modulation of the properties based on the filler content, enhancing at the same time their degradation rate, making them a promising and more sustainable alternative to traditional polymers.
Graphical Abstract
Seismic sequence stratigraphy and depositional evolution of the Cretaceous-Paleogene sedimentary successions in the offshore Taranaki Basin, New Zealand: implications for hydrocarbon exploration
Authors: Leila Mahmoud , El-Sheikh Islam , Abdelmaksoud Ahmed , Radwan Ahmed A. 
Published: June 2022

AbstractThe seismic stratigraphy and sedimentary facies of the Cretaceous and Paleogene sedimentary successions in north-eastern offshore part of Taranaki Basin, New Zealand have been investigated in order to unravel their depositional evolution and identify the potential hydrocarbon plays. Interpretation of regional seismic lines covering the entire shelf-slope and deepwater regions as well as integrating seismic and sedimentary facies allows the identification of several seismic-stratigraphic sequences within the studied successions. Early Cretaceous syn-rift successions (C1 sequence) were deposited in the structural lows near the present-day slope as swamp and marsh facies changing basinwards into turbidites and marine shales. The post-rift Cretaceous sequences (C2, C3 sequences) started with the progradation of the Taranaki delta (C2A-C2D units) followed by sedimentation of the transgressive C3A-E facies accumulated in response to thermal subsidence and high-rates of clastic supply. Extensive shelf conditions prevailed during the deposition of C2 and C3 Cretaceous sequences continued during the Paleogene with deposition of uniform marine shales throughout the basin. Rates of sediment supply substantially decreased during Oligocene prompting the deposition of marine micrite-rich carbonate. Variation in fossil content confirms the occurrence of several cycles of sea level fluctuations and episodic variations in terrigenous input. Organic-rich facies could be associated with the prograding clinoforms of the C2B unit and probably contain, basinward, large amount of gas and oil prone kerogen. The transgressive facies of C2D unit may also contain organic-rich shales basinward and coal near the present day Taranaki shelf. Potential reservoirs are hosted on the C3 transgressive estuarine sandstones. Paleogene mudstones are excellent regional seals for the hydrocarbons generated and trapped in the underlying Late Cretaceous facies.
Building a three-level multimodal emotion recognition framework
Authors: Garcia-Garcia Jose Maria , Lozano Maria Dolores , Penichet Victor M. R. , Law Effie Lai-Chong 
Published: June 2022

AbstractMultimodal emotion detection has been one of the main lines of research in the field of Affective Computing (AC) in recent years. Multimodal detectors aggregate information coming from different channels or modalities to determine what emotion users are expressing with a higher degree of accuracy. However, despite the benefits offered by this kind of detectors, their presence in real implementations is still scarce for various reasons. In this paper, we propose a technology-agnostic framework, HERA, to facilitate the creation of multimodal emotion detectors, offering a tool characterized by its modularity and the interface-based programming approach adopted in its development. HERA (Heterogeneous Emotional Results Aggregator) offers an architecture to integrate different emotion detection services and aggregate their heterogeneous results to produce a final result using a common format. This proposal constitutes a step forward in the development of multimodal detectors, providing an architecture to manage different detectors and fuse the results produced by them in a sensible way. We assessed the validity of the proposal by testing the system with several developers with no previous knowledge about affective technology and emotion detection. The assessment was performed applying the Computer System Usability Questionnaire and the Twelve Cognitive Dimensions Questionnaire, used by The Visual Studio Usability group at Microsoft, obtaining positive results and important feedback for future versions of the system.