bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Usaha Batik Pada Ibu PKK Di Desa Sebanen Kecamatan Kalisat Kabupaten Jember
Authors: Rahmawati Erna Ipak , Lailia Faidatul 
Published: April 2022

Batik merupakan kerajianan yang memiliki nilai seni yang tinggi dan menjadi icon dari budaya Indonesia itu sendiri. Jember merupakan salah satu kota yang belakangan menghasilkan pembatik yang coraknya dikenal dengan “batik tembakau”. Dengan potensi yang dimiliki tidak serta merta diikuti oleh dengan Permasalahan yang dihadapi pemilik usaha batik yaitu kesulitan dalam modal dan pendanaan yang cukup, kurangnya inovasi produk dan pemanfaatan teknologi informasi dalam pemasaran produk, kurangnya peralatan produksi, kurangnya penyerapan dan pemberdayaan tenaga kerja, rencana pengembangan usaha. Harus ada usaha untuk pengembangan dan pemberdayaan masyarakat untuk memajukan usaha pengembangan batik kearah yang lebih baik dan juga mengenalkan batik Jember di Tingkat Nasional dan Internasional. Usaha dan metode yang digunakan pada pengembangan usaha batik ini adalah pelatihan dan promosi produk batik. Metode pelatihan menggunakan teknik ceramah dan demonstration and example, sedangkan pemasaran produk dengan melakukan pendampingan pada pengelolaan akun-akun media sosial. Hasil pelatihan dapat disimpulkan bahwa bahwa ibu-ibu PKK di desa Sebanen setelah mengikuti pelatihan pembuatan batik dalam rangka pengembangan usaha desa Sebanen Kecamatan Kalisat kabupaten Jember berjalan baik dan lancar. Sehingga ibu-ibu PKK mampu membuat batik dan mampu mengembangkan potensi desa tersebut yang bertujuan membantu perekonomian desa maupun personal.
Trends in the full blood count blood test and colorectal cancer detection: a longitudinal, case-control study of UK primary care patient data
Authors: Virdee Pradeep S. , Patnick Julietta , Watkinson Peter , Birks Jacqueline , Holt Tim 
Published: April 2022

Background: The full blood count (FBC) is a common blood test performed in general practice. It consists of many individual parameters that may change over time due to colorectal cancer. Such changes are likely missed in practice. We identified trends in these FBC parameters to facilitate early detection of colorectal cancer. Methods: We performed a retrospective, case-control, longitudinal analysis of UK primary care patient data. LOWESS smoothing and mixed effects models were derived to compare trends in each FBC parameter between patients diagnosed and not diagnosed over a prior 10-year period. Results: There were 399,405 males (2.3%, n = 9,255 diagnosed) and 540,544 females (1.5%, n = 8,153 diagnosed) in the study. There was no difference between cases and controls in FBC trends between 10 and four years before diagnosis. Within four years of diagnosis, trends in many FBC levels statistically significantly differed between cases and controls, including red blood cell count, haemoglobin, white blood cell count, and platelets (interaction between time and colorectal cancer presence: p <0.05). FBC trends were similar between Duke’s Stage A and D colorectal tumours, but started around one year earlier in Stage D diagnoses. Conclusions: Trends in FBC parameters are different between patients with and without colorectal cancer for up to four years prior to diagnosis. Such trends could help earlier identification.
Factores asociados al tiempo de adopción de perros procedentes de refugios en Ecuador. Un estudio observacional longitudinal
Authors: Vinueza Veloz Pamela , Fernando Vinueza Andrés , Aldaz Pachacama Nelson Renato , Álvarez Almeida Kenny Michelle 
Published: April 2022

Introducción. El abandono de perros tiene implicaciones para el bienestar animal y es un problema de salud pública. Los refugios caninos han surgido en respuesta a dicho problema y tienen el objetivo de acoger a perros callejeros para luego darlos en adopción. Desafortunadamente, la falta de políticas públicas para minimizar el abandono y reducir la sobrepoblación canina ha ocasionado, que los refugios se conviertan en sitios de estancia permanente. Objetivo. El objetivo del presente estudio fue identificar factores que moderan el tiempo de adopción de perros callejeros en la región Sierra y Oriente de Ecuador. Metodología. Para ello, se recolectó información de cuatro refugios caninos de Ecuador, de manera retrospectiva. Se estudio la relación entre las variables explicativas (sexo, edad, color de pelaje y raza) y la variable respuesta (tiempo de adopción) aplicando modelos de supervivencia de Kaplan-Meier. Resultados. La población evaluada (n=207 perros) estuvo compuesta en su mayoría por adultos (n= 62, 52.1%), hembras (n=115, 56%), mestizos (n=185, 89%) y, por perros de pelaje amarillo (n=59, 29%). El tiempo promedio de adopción fue de 188 días (DE=18,0). El principal factor que se asoció al tiempo de adopción fue la edad, siendo los cachorros y juveniles los que fueron adoptados en menor tiempo. Adicionalmente, factores como el sexo, raza o color de pelaje no se asociaron de manera estadísticamente significativa con el tiempo de adopción. Conclusión.
System Performance and User Feedback Regarding Wearable Bioimpedance System for Multi-Site Knee Tissue Monitoring: Free-Living Pilot Study With Healthy Adults
Authors: Critcher Shelby , Freeborn Todd J. 
Published: April 2022

Knee-focused wearable devices have the potential to support personalized rehabilitation therapies by monitoring localized tissue alterations related to activities that reduce functional symptoms and pain. However, supporting these applications requires reported data to be reliable and accurate which can be challenging in the unsupervised free-living conditions that wearable devices are deployed. This pilot study has assessed a knee-focused wearable sensor system to quantify 1) system performance (operation, rates of data artifacts, environment impacts) to estimate realistic targets for reliable data with this system and 2) user experiences (comfort, fit, usability) to help inform future designs to increase usability and adoption of knee-focused wearables. Study data was collected from five healthy adult participants over 2 days, with 84.5 and 35.9% of artifact free data for longitudinal and transverse electrode configurations. Small to moderate positive correlations were also identified between changes in resistance, temperature, and humidity with respect to acceleration to highlight how this system can be used to explore relationships between knee tissues and environmental/activity context.
rs3806265 and rs4612666 of the NLRP3 Gene Are Associated With the Titer of Glutamic Acid Decarboxylase Antibody in Type 1 Diabetes
Authors: Sun Xiaoxiao , Xu Linling , Xia Ying , Luo Shuoming , Lin Jian , Xiao Yang , Huang Gan , Li Xia , Xie Zhiguo , Zhou Zhiguang 
Published: April 2022

Background and AimsThe NLRP3 gene is reportedly associated with several autoimmune diseases. However, in the Chinese Han population, whether NLRP3 polymorphisms are associated with type 1 diabetes (T1D) is unclear. Therefore, this study examined the associations of rs3806265 and rs4612666 of the NLRP3 gene with T1D susceptibility and the clinical characteristics of Chinese Han T1D patients.MethodsIn total, 510 classic T1D patients and 531 healthy controls from the Chinese Han population were recruited for a case-control study. rs3806265 and rs4612666 of the NLRP3 gene were genotyped by MassARRAY. Logistic regression analysis and the chi-square test were used to compare the distributions of the alleles and genotypes of rs3806265 and rs4612666. The relationships between rs3806265 and rs4612666 and the clinical characteristics of T1D patients were analyzed by Kruskal-Wallis one-way ANOVA. Student’s t test was used to analyze normally distributed data. Bonferroni correction was used for multiple comparisons.Results1) rs3806265 was associated with glutamic acid decarboxylase antibody (GADA) titers (P = 0.02), and patients with the CC genotype had higher GADA titers than patients with the TT genotype. 2) rs4612666 was also associated with GADA titers (P=0.041). Compared with patients with the CC genotype, patients with the TT genotype had higher GADA titers. 3) rs3806265 and rs4612666 of the NLRP3 gene were not significantly associated with T1D susceptibility under different genetic models.Conclusionrs3806265 and rs4612666 of the NLRP3 gene were significantly associated with GADA titers in Chinese Han T1D patients.
Abnormal BMI in Male and/or Female Partners Are Deleterious for Embryonic Development and Pregnancy Outcome During ART Process: A Retrospective Study
Authors: Qi Lin , Liu Ya-ping , Wang Shi-ming , Shi Hao , Chen Xiao-li , Wang Ning-ning , Su Ying-chun 
Published: April 2022

ObjectiveTo investigate the effect of BMI in male and/or female partners on embryo development and clinical pregnancy outcome during ART.MethodsData of 11,130 cycles between January 2018 and December 2020 were retrospectively analyzed. They were divided into Group A, B, C, and D based on couples’ BMI values, also were divided into Group I, II, III and IV in IVF cycles and Group i, ii, iii, and iv in ICSI cycles. After grouping, inter-group indicators comparisons and logistic regression analysis were performed.ResultsIn IVF cycles, CPR in Group I and Group III were higher than Group IV. In Group III, it was higher than Group II. The AR in Group IV was higher, but the LBR was lower than Group I, Group II, and Group III. Logistic regression analysis results suggested that AR in Group IV was higher than that in Group I in IVF cycles, whereas LBR was lower.In ICSI cycles, high-quality embryo rate in Group i and Group ii were both higher than that in Group iii and Group iv. The CPR in Group i was higher than Group ii and Group iv, and in Group iii was higher than Group ii and Group iv. The AR in Group i was lower than Group iii and Group iv, and AR in Group ii was lower than Group iv. LBR, in Group I it was higher than Group ii, Group iii, and Group iv. Logistic regression analysis results suggested CPR in Group ii was significantly lower than that in Group i. AR in Group iii was considerably higher than that in Group i. LBR in Group ii and Group iv were significantly lower than that in Group i.ConclusionFemale higher BMI was not conducive to the formation of high-quality embryos in ICSI cycle. Female and/or male BMI affected AR and LBR more than CPR not only in IVF cycles, but also in ICSI cycles.
Case Report: Acute Pancreatitis Associated With Tacrolimus in Kidney Transplantation and a Review of the Literature
Authors: Ding Yixuan , Qu Chang , He Huan , Cao Feng , Ou Tongwen , Li Fei 
Published: April 2022

BackgroundDrug-induced pancreatitis is a rare cause of acute pancreatitis. Tacrolimus has been used as an immunosuppressant agent in patients after organ transplantation. However, only a few case reports of tacrolimus-induced acute pancreatitis in kidney transplantation have been reported. The purpose of this case report is to alert clinicians that tacrolimus-induced acute pancreatitis may occur during tacrolimus therapy in kidney transplant patients.Case PresentationWe present the case of a 38-year-old woman who underwent kidney transplantation and received immunosuppressive therapy with tacrolimus; on day 20 post-transplantation, she presented with acute abdominal pain in the middle and left areas of the abdomen accompanied by diarrhea, nausea, and vomiting. We excluded gallstone disease, alcohol, hypertriglyceridemia, and other possible causes, and speculated that tacrolimus was the probable cause of pancreatitis because of the extremely high blood concentration of tacrolimus. After tacrolimus was changed to cyclosporine, her symptoms were gradually improved, and she was discharged home without relapse.ConclusionTacrolimus is a rare cause of pancreatitis after kidney transplantation. It is important to note that tacrolimus-induced acute pancreatitis may occur during tacrolimus therapy in kidney transplantation patients.
Mycoplasma pneumonia Infection Is Associated With an Increased Risk of Systemic Lupus Erythematosus: A Nationwide, Retrospective Cohort Study
Authors: Chu Kuo-An , Ou Ting-Yun , Hung Wei-Hsin , Sung Jie , Chen Weishan , Lin Cheng-Li , Hung Yao-Min , Wei James Cheng-Chung 
Published: April 2022

BackgroundInfections may play a role in the development of systemic lupus erythematosus (SLE).ObjectiveTo assess the link between Mycoplasma pneumonia (M. pneumonia) infection and the incidence of SLE.MethodWe conducted a retrospective cohort study, which identified 116,043 hospitalized patients with M. pneumoniae between 2000 and 2012 from the Taiwan National Health Insurance Research Database and compared them with 447,839 matched inpatients who had never been diagnosed with M. pneumonia infection (at a 1:4 ratio, matched by age, gender, and index year). Their comparative risk of developing SLE was evaluated. The follow-up period was defined as the time from the initial diagnosis of M. pneumonia infection to the date of SLE diagnosis, or December 31, 2013. The incidence rates of SLE were assessed in people with and without M. pneumoniae infection. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs), with the uninfected group used as the reference.ResultsThe adjusted HR of SLE for the M. pneumoniae group was 2.97 with 95% CI = 2.18–4.05 compared with the uninfected group. The risk was most significantly higher within 0.5 years after the M. pneumoniae infection with an adjusted HR of 6.18 (95% CI = 3.82–9.97, p &lt; 0.01). The adjusted HR for SLE from 0.5 to 2 years and from 2 to 5 years after M. pneumoniae infection was 1.59 (95% CI = 0.70–3.59, p = 0.27) and 2.42 (95% CI = 1.22–4.81, p = 0.01), respectively.ConclusionThe incidence of SLE was significantly higher in subjects infected with M. pneumoniae.
Diagnostic Performance of Generative Adversarial Network-Based Deep Learning Methods for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Authors: Qu Changxing , Zou Yinxi , Ma Yingqiao , Chen Qin , Luo Jiawei , Fan Huiyong , Jia Zhiyun , Gong Qiyong , Chen Taolin 
Published: April 2022

Alzheimer’s disease (AD) is the most common form of dementia. Currently, only symptomatic management is available, and early diagnosis and intervention are crucial for AD treatment. As a recent deep learning strategy, generative adversarial networks (GANs) are expected to benefit AD diagnosis, but their performance remains to be verified. This study provided a systematic review on the application of the GAN-based deep learning method in the diagnosis of AD and conducted a meta-analysis to evaluate its diagnostic performance. A search of the following electronic databases was performed by two researchers independently in August 2021: MEDLINE (PubMed), Cochrane Library, EMBASE, and Web of Science. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool was applied to assess the quality of the included studies. The accuracy of the model applied in the diagnosis of AD was determined by calculating odds ratios (ORs) with 95% confidence intervals (CIs). A bivariate random-effects model was used to calculate the pooled sensitivity and specificity with their 95% CIs. Fourteen studies were included, 11 of which were included in the meta-analysis. The overall quality of the included studies was high according to the QUADAS-2 assessment. For the AD vs. cognitively normal (CN) classification, the GAN-based deep learning method exhibited better performance than the non-GAN method, with significantly higher accuracy (OR 1.425, 95% CI: 1.150–1.766, P = 0.001), pooled sensitivity (0.88 vs. 0.83), pooled specificity (0.93 vs. 0.89), and area under the curve (AUC) of the summary receiver operating characteristic curve (SROC) (0.96 vs. 0.93). For the progressing MCI (pMCI) vs. stable MCI (sMCI) classification, the GAN method exhibited no significant increase in the accuracy (OR 1.149, 95% CI: 0.878–1.505, P = 0.310) or the pooled sensitivity (0.66 vs. 0.66). The pooled specificity and AUC of the SROC in the GAN group were slightly higher than those in the non-GAN group (0.81 vs. 0.78 and 0.81 vs. 0.80, respectively). The present results suggested that the GAN-based deep learning method performed well in the task of AD vs. CN classification. However, the diagnostic performance of GAN in the task of pMCI vs. sMCI classification needs to be improved.Systematic Review Registration: [PROSPERO], Identifier: [CRD42021275294].
Elevations in Tumor Necrosis Factor Alpha and Interleukin 6 From Neuronal-Derived Extracellular Vesicles in Repeated Low-Level Blast Exposed Personnel
Authors: Edwards Katie A. , Leete Jacqueline J. , Smith Ethan G. , Quick Alycia , Modica Claire M. , Wassermann Eric M. , Polejaeva Elena , Dell Kristine C. , LoPresti Matthew , Walker Peter , O'Brien Meghan , Lai Chen , Qu Bao-Xi , Devoto Christina , Carr Walter , Stone James R. , Ahlers Stephen T. , Gill Jessica M. 
Published: April 2022

ObjectiveThe purpose of this pilot study was to determine if military service members with histories of hundreds to thousands of low-level blast exposures (i. e., experienced breachers) had different levels of serum and neuronal-derived extracellular vesicle (EV) concentrations of interleukin (IL)-6, IL-10, and tumor necrosis factor alpha (TNFα), compared to matched controls, and if these biomarkers related to neurobehavioral symptoms.MethodsParticipants were experienced breachers (n = 20) and matched controls without blast exposures (n = 14). Neuronal-derived EVs were isolated from serum and identified with mouse anti-human CD171. Serum and neuronal-derived EVs were analyzed for IL-6, IL-10, and TNFα using an ultra-sensitive assay.ResultsSerum TNFα concentrations were decreased in breachers when compared to control concentrations (p &lt; 0.01). There were no differences in serum concentrations of IL-6, IL-10, or the IL-6/IL-10 ratio between breachers and controls (p's &gt; 0.01). In neuronal-derived EVs, TNFα and IL-6 levels were increased in breachers compared to controls (p's &lt; 0.01), and IL-10 levels were decreased in the breacher group compared to controls (p &lt; 0.01). In breachers the IL-6/IL-10 ratio in neuronal-derived EVs was higher compared to controls, which correlated with higher total Rivermead Post-concussion Questionnaire (RPQ) scores (p's &lt; 0.05).ConclusionsThese findings suggest that exposure of personnel to high numbers of low-level blast over a career may result in enduring central inflammation that is associated with chronic neurological symptoms. The data also suggest that peripheral markers of inflammation are not necessarily adequate surrogates for central neuroinflammation.
Association Between Partial Pressure of Carbon Dioxide and Immediate Seizures in Patients With Primary Intracerebral Hemorrhage: A Propensity-Matched Analysis
Authors: Pan Zhiming , Zhong Qiuli , Wang Chaoying , Wang Jianqun , Chen Xiaoyan , Li Xiaoyan , Zhang Xintong , Zhang Yibin 
Published: April 2022

PurposeTo explore the value of partial pressure of carbon dioxide (PaCO2) levels in arterial blood for predicting immediate seizures (ISs) in patients with primary intracerebral hemorrhage (ICH).MethodsDemographic information and clinical data from patients with primary ICH were prospectively collected, including arterial blood gas analysis. Immediate seizures (ISs) were determined as seizures in the first 24 h after admission. Univariate and multivariate analyses were performed to assess the association of PaCO2 levels with ISs. Propensity-score matching (PSM) analyses were adopted to reduce the baseline difference between ISs and non-ISs groups.ResultsA total of 596 patients with primary ICH were initially screened in this clinical study, 368 of whom fulfilled all the inclusion criteria [mean age, (60.46 ±12.78) years; 57.9% female patients]. ISs occurred in 30 of the 368 (8.15%) patients with primary ICH of this cohort. Patients with ISs had significantly lower PaCO2 levels [34.35(32.38–37.53) vs. 39.45(35.90–43.43), mmHg, p &lt; 0.001] and were younger than those without ISs [(54.57±12.15 vs. 60.99 ±12.72) years, p = 0.008]. Multivariate analysis showed that lower initial PaCO2 (≤37.2 mmHg) level was a significant independent predictor of ISs [odds ratios (OR) 0.141, 95% confidence interval (CI) 0.057–0.351, p &lt; 0.001], as well as younger age (OR 0.961, 95% CI 0.928–0.995, p = 0.023) and hematoma expansion (OR 0.340, 95% CI 0.134–0.863, p = 0.023). Receiver operating characteristic curve (ROC) analysis demonstrated that the optimal cutoff value of PaCO2 level for predicting ISs was 37.20 mmHg in patients with primary ICH (the area under the curve (AUC) was 0.760 with a corresponding sensitivity of 76.67% and specificity of 67.46%, 95%CI = 0.713–0.802, p &lt; 0.001). After PSM, the matched ISs group had significantly lower PaCO2 levels compared with the matched non-ISs group [34.45(32.43–38.18) vs. 41.75(35.85–43.98) mmHg, p &lt; 0.05] in the univariate analysis. The lower initial PaCO2 level was still independent of ISs following primary ICH.ConclusionsThe lower initial PaCO2 level was associated with an increased risk of ISs in patients with primary ICH.
Neoadjuvant Chemoradiotherapy Changes the Landscape of Soluble Immune Checkpoint Molecules in Patients With Locally Advanced Rectal Cancer
Authors: Liu Chao , Wang Peiliang , Sun Yi , Dou Xue , Hu Xiaoyu , Zou Wenxue , Sun Yanlai , Hu Qinyong , Yue Jinbo 
Published: April 2022

BackgroundWe aimed to investigate clinical implications of specific soluble immune checkpoint molecules (sICMs) in locally advanced rectal cancer (LARC) patients treated with neoadjuvant chemoradiotherapy (nCRT).MethodsWe prospectively enrolled 30 LARC patients treated with nCRT and collected blood samples from them before, during, and after nCRT for prospective studies. Immune checkpoints often refer to T cell surface molecules influencing the immune response. Immune checkpoints, in the form of a soluble monomeric form, is widely present in blood. In the study, eight immune checkpoint-related plasma proteins, including programmed death-ligand 1 (PD-L1), CD80, CD86, CD28, CD27, glucocorticoid-induced tumor necrosis factor receptor (GITR), GITR ligand (GITRL), and inducible T-cell costimulator (ICOS), were measured using the Luminex platform. Two independent pathologists categorized patients as the good responders and the poor responders according to Dworak tumor regression grade (TRG).ResultsOf the 30 patients, the levels of sPD-L1, sCD80, sCD86, sCD28, sGITR, sGITRL, sCD27, and sICOS decreased during nCRT (Pre-nCRT vs. During-nCRT, all p&lt;0.05) but were restored after nCRT treatment (Pre-nCRT vs. Post-nCRT, all p&gt;0.05). In the 14 good responders, the levels of sICMs, other than sGITR (p=0.081) and sGITRL (p=0.071), decreased significantly during nCRT (Pre-nCRT vs. During-nCRT, p&lt;0.05), but they were all significantly increased after nCRT (During-nCRT vs. Post-nCRT, all p&lt;0.05). In the 16 poor responders, only sCD80 was significantly reduced during nCRT (Pre-nCRT vs. During-nCRT, p&lt;0.05), and none was significantly increased after nCRT (During-nCRT vs. Post-nCRT, all p&lt;0.05). High levels of sICMs before nCRT were associated with poor response (all OR≥1). The Pre-model that incorporated the 8 sICMs before nCRT yielded a good predictive value (AUC, 0.848) and was identified as an independent predictor of treatment response (OR, 2.62; 95% CI, 1.11-6.18; p=0.027).ConclusionOur results suggest chemoradiotherapy could influence the change of sPD-L1, sCD80, sCD86, sCD28, sGITR, sGITRL, sCD27, and sICOS in patients with LARC. The levels of the majority of soluble immune checkpoint molecules were reduced during nCRT and then restored at the end of nCRT, particularly in patients who responded well to nCRT. Combined baseline sICMs can be developed to predict treatment response.