bluuebunny/crossref_metadata_2025_split huggingface dataset:
4‐triphenylmethylaniline substituted cyclotriphosphazene derivatives assisted by multiple phenyl rings
Authors: Mutlu Balcı Ceylan , Palabıyık Duygu 
Published: April 2022

AbstractIn the present study, nucleophilic substitution reactions of hexachlorocyclotriphosphazene (1) and 4‐triphenylmethylaniline (2) were carried out under different mole ratios. As a result of the reactions, mono (3), bis geminal (4), tetrakis geminal (5), and hexakis substituted (6) cyclotriphosphazene derivatives formed. The product diversity and yields of new cyclotriphosphazene derivatives (3–6) were comprehensively investigated by using the proton‐decoupled 31P Nuclear Magnetic Resonance (NMR) spectra of the reaction mixtures. Pure cyclotriphosphazene derivatives (3–5) have been characterized by 1H, 13C and 31P NMR, MALDI‐TOF mass and elemental analyses. The structure of compound 4 was also elucidated by single crystal X‐ray diffraction technique. Along with the spectroscopic techniques, the thermal stabilities of 4‐triphenylmethylaniline substituted cyclotriphosphazene derivatives (4 and 5) were determined by thermogravimetric analysis (TGA) technique.
SLC2A3 variants in familial and sporadic congenital heart diseases in a Chinese Yunnan population
Authors: Ma Lijing , Xu Jiaxin , Tang Qisheng , Cao Yu , Kong Ruize , Li Kunlin , Liu Jie , Jiang Lihong 
Published: April 2022

AbstractBackgroundSolute carrier family 2 member 3 (SLC2A3), is a member of a superfamily of transport protein genes. SLC2A3 played an important role in embryonic development. Previous research reported SLC2A3 duplication was reportedly associated with congenital syndromic heart defects. However, it is not clear whether the gene is associated with non‐syndromic congenital heart disease. Our study aimed to elucidate the relationship between its variation and congenital heart disease.MethodsGenomic DNA extracted from the peripheral blood leukocytes of two families with CHD were sequenced with whole‐exome sequencing to identify variations, used Sanger sequencing to investigate SLC2A3 variants in 494 Chinese patients with CHD and 576 healthy unrelated individuals.ResultsIn members from the two families, three with CHD had the SLC2A3 (rs3931701) C > T variant. Of the 494 patients with CHD, 394 had gene variants (86 had the TT type and 308 had the CT type). Of the 576 healthy controls, 272 participants had gene variants (36 had the TT type and 236 had the CT type). The TT type [p < 0.0001, odds ratio (OR) =7.262, 95% confidence interval (CI) =4.631–11.388] and CT type (p < 0.0001, OR =3.967, 95% CI =2.991–5.263) of SLC2A3 (rs3931701) significantly increased the risk of sporadic ASD in a Chinese Yunnan population.ConclusionsSingle nucleotide variations of SLC2A3, particularly, the SLC2A3 (rs3931701) C > T variant increased the risk of CHD among the studied population.
Disclosure of suicidal thoughts and behaviors: The impact of suicide event type
Authors: Ammerman Brooke A. , Park Yeonsoo , O'Loughlin Caitlin M. 
Published: April 2022

AbstractObjectivesDespite its importance, limited work has investigated the nuances of suicidal thoughts and behavior self‐disclosure. The present study aimed to examine potential differences in self‐disclosure based on whether an individual has disclosed suicidal thinking versus behavior.MethodsTwo hundred and four participants having disclosed their suicidal thoughts or behaviors completed a battery of online questionnaires assessing several key aspects of disclosure (i.e., disclosure recipient, perceived helpfulness of disclosure, impact on treatment seeking), as it pertained to both one's first and overall disclosure experiences.ResultsIndividuals who disclosed a suicide attempt, versus ideation, were more likely to have disclosed to a formal support (i.e., health professional) and to seek professional help following disclosure. No significant group differences in perceived helpfulness of experiences were found.ConclusionIt may be beneficial to increase opportunities for disclosure of suicidal thinking. Overall, disclosures were perceived as helpful and may not impede future help‐seeking behavior.
New reactions of 3,4‐dihydro‐6,7‐dimethoxyisoquinoline ylide with nitrile derivatives
Authors: Molnár Márk , Treuerne Balázs Krisztina E. , Madarász Zoltán , Nyerges Miklós 
Published: April 2022

AbstractNovel examples for dipolar cycloaddition of isoquinolinium ylides to nitriles leading to new imidazo[2,1‐a]isoquinolines were described and the potential of this reaction in synthetic chemistry was explored. As a by‐product of this research, a number of N‐substituted, 3,4‐dihydro‐1H‐isoquinoline‐1‐carbonitriles were synthesized by a simple, efficient reaction of a series of isoquinolinium bromides and ethyl cyanoformate in the presence of triethylamine.
Automated radiochemical synthesis of pharmaceutical grade [18F]FLT using 3‐N‐Boc‐5′‐O‐dimethoxytrityl‐3′‐O‐nosyl‐thymidine precursor and its Sep‐Pak® purification employing selective elution from reversed phase
Authors: Mitra Arpit , Chakraborty Avik , Upadhye Trupti , Tawate Megha , Lad Sangita , Sahu Sudeep , Rajesh Chinagandham , Bagul Swati , Pawar Yogita , Ray Mukti Kant , Banerjee Sharmila 
Published: April 2022

Pharmaceutical grade 3′‐deoxy‐3′‐[18F]fluorothymidine [18F]FLT was synthesized using 3‐N‐Boc‐5′‐O‐dimethoxytrityl‐3′‐O‐nosyl‐thymidine (BOC‐Nosyl) precursor, in the general purpose TRACERlab FX modules. Purification of [18F]FLT, via solid phase extraction (SPE) after radiosynthesis, using a combination of different SPE cartridges, yielded satisfactory results, with radiochemical and chemical purity >99%. While the non‐decay corrected radiochemical yield (RCY) with 20 mg (24 μmole) of BOC‐Nosyl precursor was found to be 6.80 ± 0.16%, the decay corrected radiochemical yield (RCY) was 9.95 ± 0.24%. Residual acetone, acetonitrile, and ethanol levels were found to be 22.97 ± 0.76, 109.08 ± 0.93, and 7,666.45 ± 3.7 ppm, respectively. A simplified method for solid‐phase purification of [18F]FLT was developed, circumventing the need for HPLC purification. Biodistribution in C57BL/6 mice with B16F10 cell line‐induced melanoma showed tumor to blood ratio of ~3.8 at 90 min. PET/CT imaging of normal rabbit injected with [18F]FLT shows selective uptake in the bone marrow and small intestine. [18F]FLT was found to be excreted through the kidneys and get collected in the urinary bladder, 120 min post injection. PET/CT imaging performed in rabbit model at 30, 60, 90, and 120 min post [18F]FLT injections showed concordance with tissue distribution kinetics of mice tumor model.
Comparison of hematologic abnormalities between hospitalized coronavirus disease 2019 positive and negative patients with correlation to disease severity and outcome
Authors: Jain Swasti , Meena Rachana , Kumar Vijay , Kaur Ranvinder , Tiwari Umesh 
Published: April 2022

AbstractPeripheral blood smear (PBS) changes in coronavirus disease 2019 (COVID‐19) are diverse and have been reported in the literature in the form of case series with relatively smaller sample sizes and with a handful of studies showing the association between PBS and clinical severity. This study aims to highlight the numerical and morphological changes in peripheral blood of COVID‐19 patients and to compare the same in intensive care unit (ICU) and non‐ICU settings as well as with disease severity and outcome. The study included 80 COVID‐19 positive (41 ICU and 39 non‐ICU) patients and 32 COVID‐19 negative ICU patients. Complete blood counts (CBCs) and PBS findings were studied and scored by two pathologists blindfolded. Absolute lymphocyte count (ALC) and absolute eosinophil count (AEC) were significantly lower in COVID‐19 positive cases as compared to the COVID‐19 negative group (p = 0.001 and p = 0.001). COVID‐19 positive group showed significant left myeloid shift (p = 0.021), Dohle bodies (p = 0.025) with significant prominence of acquired pseudo–Pelger–Huët anomaly, ring‐shaped neutrophils, monolobate neutrophils, and plasmacytoid lymphocytes as compared to control group (p = 0.000, p = 0.009, p = 0.046, and p = 0.011, respectively). The overall mean white blood cell (WBC) counts were higher in COVID‐19 positive ICU patients as compared to non‐ICU COVID patients with significant shift to left, presence of ring‐shaped neutrophils, monocyte vacuolation, and large granular lymphocytes (p = 0.017, p = 0.007, p = 0.008, and p = 0.004, respectively). Deceased group showed significantly higher WBC count (p = 0.018) with marked neutrophilia (p = 0.024) and toxic granulation (p = 0.01) with prominence of monocyte vacuolization, ring‐shaped neutrophils, large granular lymphocytes, and reactive lymphocytes. Parameters like myeloid left shift, ring‐shaped neutrophils, monocyte vacuolation, and large granular lymphocytes emerged as highly sensitive markers of disease severity. Therefore, serial CBC with comprehensive PBS analysis should be done in every newly diagnosed hospitalized COVID‐19 patient which potentially predicts the course of the disease.
Gender diversity and team performance under time pressure: The role of team withdrawal and information elaboration
Authors: Kearney Eric , Razinskas Stefan , Weiss Matthias , Hoegl Martin 
Published: April 2022

SummaryFindings in the extant literature are mixed concerning when and how gender diversity benefits team performance. We develop and test a model that posits that gender‐diverse teams outperform gender‐homogeneous teams when perceived time pressure is low, whereas the opposite is the case when perceived time pressure is high. Drawing on the categorization‐elaboration model (CEM; van Knippenberg, De Dreu, & Homan, 2004), we begin with the assumption that information elaboration is the process whereby gender diversity fosters positive effects on team performance. However, also in line with the CEM, we argue that this process can be disrupted by adverse team dynamics. Specifically, we argue that as time pressure increases, higher gender diversity leads to more team withdrawal, which, in turn, moderates the positive indirect effect of gender diversity on team performance via information elaboration such that this effect becomes weaker as team withdrawal increases. In an experimental study of 142 four‐person teams, we found support for this model that explains why perceived time pressure affects the performance of gender‐diverse teams more negatively than that of gender‐homogeneous teams. Our study sheds new light on when and how gender diversity can become either an asset or a liability for team performance.
Inkjet‐printed multi‐color arrays based on eco‐friendly quantum dot light emitting diodes with tailored hole transport layer
Authors: Zhan Shijie , Suh Yo‐Han , Fan Xiang‐Bing , Yang Jiajie , Ni Limeng , Kim Yoonwoo , Jo Jeong‐Wan , Choi Hyung Woo , Jung Sung‐Min , Shin Dong‐Wook , Lee Sanghyo , Kim Jong Min 
Published: April 2022

AbstractCadmium‐free quantum dot light‐emitting diodes (QLEDs) have held the potential to revolutionize the next‐generation displays with their advantages in color gamut, luminance intensity, and solution processibility. As a promising way of realizing large‐area QLED display production, inkjet printing has been intensively studied on Cd‐based QLEDs but lacks exploration in fabricating Cd‐free devices. Here, we developed Cd‐free RGB inkjet‐printed QLEDs with tailored hole transport layers (t‐HTLs) using Cd‐free QDs including InP/ZnSeS red and green QDs and ZnTeSe/ZnSe/ZnS blue QDs. With the t‐HTLs, QD ink erosion on the bottom charge transport layer was remarkably suppressed, while the efficient hole transport was maintained, which kept high device performance, especially in the QLED lifetime. With bank structures, Cd‐free QLED pixels were well defined within the size of 60 μm × 160 μm. Based on the t‐HTL structure and the bank structures, inkjet‐printed Cd‐free RGB QLED pixel arrays were demonstrated. This study bridges the gap between existing Cd‐free QLED technologies and the future commercialization of Cd‐free self‐emissive QD displays.
Polymerized Naphthalimide Derivatives as Remarkable Electron‐Transport Layers for Inverted Organic Solar Cells
Authors: Wang Linqiao , Chen Yaoqiong , Tao Wuxi , Wang Ke , Peng Zeyan , Zheng Xiaolong , Xiang Changhao , Zhang Jian , Huang Meihua , Zhao Bin 
Published: April 2022

AbstractTwo polymerized naphthalimide derivatives, named as N‐TBHOB and N‐DBH, are prepared by quaternization. They exhibit excellent performance as electron‐transport layers (ETLs) in inverted organic solar cells (i‐OSCs). The results indicate N‐TBHOB with a reticulated structure owns a superior performance on electron extraction, electron transport, thickness tolerance, and less carrier recombination compared with N‐DBH with linear structure. The i‐OSCs based on N‐TBHOB with PTB7‐Th:PC71BM as the active layer achieve power conversion efficiencies (PCEs) of 10.72% and 10.03% under the thickness of 11 and 48 nm respectively, which indicates N‐TBHOB possesses better thickness tolerance than most of organic ETLs in i‐OSCs. N‐TBHOB also shows more competent performance than N‐DBH and ZnO in nonfullerene i‐OSCs for comprehensively improved Jsc, Voc, and fill factor (FF) values. Its i‐OSC with PM6:Y6 blend presents a high PCE of 16.78%. The study provides an efficient strategy to prepare ETLs by combining conjugated and nonconjugated units with a reticulated structure in the backbone for high‐performance i‐OSCs.
Bilateral Focused Ultrasound Pallidotomy for Parkinson‐Related Facial Dyskinesia—A Case Report
Authors: Stieglitz Lennart H. , Mahendran Sujitha , Oertel Markus F. , Baumann Christian R. 
Published: April 2022

AbstractBackgroundFor safety reasons, both magnetic resonance‐guided high‐intensity focused ultrasound (MRgHiFUS) thalamotomy and pallidotomy are currently approved exclusively for unilateral treatment, but axial symptoms like levodopa‐induced orofacial dyskinesia require a bilateral approach.ObjectivesWe report the first case of successful bilateral MRgHiFUS pallidotomy for peak‐dose dyskinesia in a patient with Parkinson's disease (PD).MethodsThe treatment decision was based on the patient's reluctance toward brain implants and pump therapies and the fact that he had limited access to a deep brain stimulation center in his home country. The treatment was planned as staged procedure with an interval of 18 months because of travel restrictions because of the coronavirus disease (COVID)‐19 pandemic.ResultsAfter the second treatment, levodopa‐induced orofacial dyskinesia remitted and improved bradykinesia and rigidity with stable gait and good postural reflexes.ConclusionsThis promising result suggests that in selected PD patients with dyskinesia, staged bilateral MRgHiFUS pallidotomy might be considered.
Paradigm Shift: Applying Capture–Recapture Techniques to Electronic Licensing System Data to Estimate Chinook Salmon Harvest
Authors: Riggers Brian L. , Jones Michelle K. 
Published: April 2022

Abstract
Implementing creel surveys that produce robust and unbiased estimates of harvest can be complicated, expensive, and labor intensive. Additionally, field personnel often face safety risks associated with traversing roads and highways, occasionally under inclement travel conditions. Here, we develop an alternative method to estimate recreational fish harvest using a hybrid creel that employs capture–recapture techniques in conjunction with data collected from the Oregon Department of Fish and Wildlife's electronic licensing system. We evaluated the method by comparing harvest estimates between the new approach (e-creel) and estimates from a traditional roving creel conducted on four of Oregon's coastal Chinook Salmon Oncorhynchus tshawytscha populations in 2019. Our results indicated that Chinook Salmon harvest estimates derived from our hybrid creel approach were more precise than estimates using traditional creel methods. Both methods generated statistically equivalent estimates of Chinook Salmon recreational harvest, differing by only 3.4%. Estimated mean harvest was 1,264 Chinook Salmon based on the e-creel approach versus 1,258 based on the traditional creel approach. On average, the e-creel estimates reduced the SE by 41% relative to traditional creel estimates. Post hoc assessment of spending associated with creel projects in 2019 suggested that a total savings of US$74,525 in personnel and operational cost, corresponding to an average 15% budget reduction per investigation, could be realized by transitioning from a traditional creel design to an e-creel design.
Time‐adaptive Adomian decomposition‐based numerical scheme for Euler equations
Authors: Garcia‐Beristain Imanol , Remaki Lakhdar 
Published: April 2022

AbstractTime efficiency is one of the more critical concerns in computational fluid dynamics simulations of industrial applications. Extensive research has been conducted to improve the underlying numerical schemes to achieve time process reduction. Within this context, this paper presents a new time discretization method based on the Adomian decomposition technique for Euler equations. The obtained scheme is time‐order adaptive; the order is automatically adjusted at each time step and over the space domain, leading to significant processing time reduction. The scheme is formulated in an appropriate recursive formula, and its efficiency is demonstrated through numerical tests by comparison to exact solutions and the popular Runge–Kutta‐discontinuous Galerkin method.
Untargeted metabolomics identifies the potential role of monocarboxylate transporter 6 (MCT6/SLC16A5) in lipid and amino acid metabolism pathways
Authors: Ren Tianjing , Jones Robert S. , Morris Marilyn E. 
Published: April 2022

AbstractMonocarboxylate transporter 6 (MCT6; SLC16A5) is an orphan transporter protein with expression in multiple tissues. The endogenous function of MCT6 related to human health and disease remains unknown. Our previous transcriptomic and proteomic analyses in Mct6 knockout (KO) mice suggested that MCT6 may play a role in lipid and glucose homeostasis, but additional evidence is required. Thus, the objective of this study was to further explore the impact of MCT6 on metabolic function using untargeted metabolomic analysis in Mct6 KO mice. The plasma from male and female mice and livers from male mice were submitted for global metabolomics analysis to assess the relative changes in endogenous small molecules across the liver and systemic circulation associated with absence of Mct6. More than 782 compounds were detected with 101 and 51 metabolites significantly changed in plasma of male and female mice, respectively, and 100 metabolites significantly changed in the livers of male mice (p < .05). Significant perturbations in lipid metabolism were annotated in the plasma and liver metabolome, with additional alterations in the amino acid metabolism pathway in plasma samples from male and female mice. Elevated lipid diacylglycerol and altered fatty acid metabolite concentrations were found in liver and plasma samples of male Mct6 KO mice. Significant reduction of N‐terminal acetylated amino acids was found in plasma samples of male and female Mct6 KO mice. In summary, the present study confirmed the significant role of MCT6 in lipid and amino acid homeostasis, suggesting its contribution in metabolic diseases.
On‐Site Preparation of Natural Deep Eutectic Solvents Using Solar Energy
Authors: Dazat Ricardo Elia , Vidal Ezequiel , Lorenzetti Anabela S. , García Carlos D. , Domini Claudia , Silva María F. , Gomez Federico J. V. 
Published: April 2022

AbstractNatural Deep Eutectic Solvents (NADES) are currently one of the greenest solvents for both academic and industrial purposes. Despite their advantages with respect to traditional solvents, their synthesis typically requires access to power, limiting their applicability to address problems in remote locations. Addressing this shortcoming, this report describes the possibility to use a 3D‐printed solar concentrator for the on‐site preparation of NADES, approach that not only provides a simple way to adjust synthetic conditions but also represents the greenest method for their synthesis reported to date. To highlight the advantages of the approach, the preparation of twelve representative NADES was performed and benchmarked against one of the most traditional methods, involving heating and stirring. According to our results, most of the NADES tested could be prepared on‐site in <40 min and with minimal hardware requirements. Additionally, the NADES prepared were used for the extraction of chlorophyll from Vitis vinifera leaves, prior to its quantification using a smartphone and a 3D printed fluorometer. The greenness of the proposed method (calculated using the AGREE software) rendered a score of 0.86, the best reported to date.
Highly Efficient Removal of Congo Red from Aqueous Solution by Lime‐Preconditioned Phosphogypsum
Authors: Deng Qiulin , Luo Qin , Li Ming , Tu Junhong , Guo Liqing , Wu Liangxian , Zhang Tao , Shi Lianjun , Zhang Hong , Dong Faqin 
Published: April 2022

AbstractPhosphogypsum (PG) modified by milk of lime (namely lime‐preconditioned phosphogypsum, PPG) is investigated to evaluate the adsorption thereof for removing Congo Red (CR) from aqueous solution. The experimental parameters, such as adsorbent dosage, pH, adsorption temperature, initial CR concentration and contact time, are carefully studied in the batch system. FT‐IR, XRD, BET and SEM are used to characterize the structure and morphology of PPG in the various conditions. The adsorption kinetic and isotherm of PPG onto CR from aqueous solution are fitted using quasi‐first‐order and quasi‐second‐order kinetic equations, and Langmuir and Freundlich models, respectively. The quasi‐second‐order kinetic equation is more suitable to describe the adsorption kinetics of CR by PPG than the quasi‐first‐order kinetic equation. The equilibrium data of CR is found to best fit to the Langmuir model. The adsorption capacity for CR achieved 79.5 mg/g according to Langmuir model. Further, the thermodynamic results show that the adsorption is an endothermic and spontaneous process. Meanwhile, desorption experiments are performed to verify and reveal the adsorption behavior. And the packed micro‐channel is firstly applied to remove CR from aqueous solution. Finally, the adsorption mechanism is speculated according the structure of CR and PPG. PG can be employed as waste‐recycling alternatives for recalcitrant dye removal from aqueous solution.
A New Zinc‐Based Metal‐Organic Framework for Catalytic Synthesis of N‐Substituted Pyrroles
Authors: Tran Y B. N. , Nguyen Phuong T. K. 
Published: April 2022

AbstractA new zinc‐based metal‐organic framework (MOF) Zn2(OAB) [OAB4−=4,4′‐(oxalylbis(azanediyl))bis(2‐oxidobenzoate)), analogous to a well‐studied MOF‐74 structure, was solvothermal synthesized and characterized. The Zn2(OAB) frameworks exhibited accessible mesopore channels (24 Å) and high porosity (SBET=3115 m2 g−1). The presence of the high density of both Lewis acidic Zn sites and −NH− groups derived from the organic OAB4− unit make Zn2(OAB) a promising candidate for catalysis Paal‐Knorr N‐substituted pyrroles synthesis. As such, Zn2(OAB) exhibited excellent catalytic activity in the synthesis of 2,5‐dimethyl‐1‐phenyl‐1H‐pyrrole with a yield of 96 % at 70 °C for 16 min. Notably, the catalytic activity of Zn2(OAB) outperformed that of homogeneous, heterogeneous catalysts, and representative Zn‐based MOFs (ZIF‐8, MOF‐5, Zn‐MOF‐74). The Zn2(OAB) was also demonstrated to be reused up to eight times without noteworthy loss of its activity.