bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of respirator versus surgical masks on SARS-CoV-2 acquisition in healthcare workers: a prospective multicentre cohort
Authors: Haller Sabine , Güsewell Sabine , Egger Thomas , Scanferla Giulia , Thoma Reto , Leal-Neto Onicio B. , Flury Domenica , Brucher Angela , Lemmenmeier Eva , Möller J. Carsten , Rieder Philip , Rütti Markus , Stocker Reto , Vuichard-Gysin Danielle , Wiggli Benedikt , Besold Ulrike , Kuster Stefan P. , McGeer Allison , Risch Lorenz , Schlegel Matthias , Friedl Andrée , Vernazza Pietro , Kahlert Christian R. , Kohler Philipp 
Published: February 2022

Abstract
Background
There is insufficient evidence regarding the role of respirators in the prevention of SARS-CoV-2 infection. We analysed the impact of filtering facepiece class 2 (FFP2) versus surgical masks on the risk of SARS-CoV-2 acquisition among Swiss healthcare workers (HCW).

Methods
Our prospective multicentre cohort enrolled HCW from June to August 2020. Participants were asked about COVID-19 risk exposures/behaviours, including preferentially worn mask type when caring for COVID-19 patients outside of aerosol-generating procedures. The impact of FFP2 on (1) self-reported SARS-CoV-2-positive nasopharyngeal PCR/rapid antigen tests captured during weekly surveys, and (2) SARS-CoV-2 seroconversion between baseline and January/February 2021 was assessed.

Results
We enrolled 3259 participants from nine healthcare institutions, whereof 716 (22%) preferentially used FFP2. Among these, 81/716 (11%) reported a SARS-CoV-2-positive swab, compared to 352/2543 (14%) surgical mask users; seroconversion was documented in 85/656 (13%) FFP2 and 426/2255 (19%) surgical mask users. Adjusted for baseline characteristics, COVID-19 exposure, and risk behaviour, FFP2 use was non-significantly associated with decreased risk for SARS-CoV-2-positive swab (adjusted hazard ratio [aHR] 0.8, 95% CI 0.6–1.0) and seroconversion (adjusted odds ratio [aOR] 0.7, 95% CI 0.5–1.0); household exposure was the strongest risk factor (aHR 10.1, 95% CI 7.5–13.5; aOR 5.0, 95% CI 3.9–6.5). In subgroup analysis, FFP2 use was clearly protective among those with frequent (> 20 patients) COVID-19 exposure (aHR 0.7 for positive swab, 95% CI 0.5–0.8; aOR 0.6 for seroconversion, 95% CI 0.4–1.0).

Conclusions
Respirators compared to surgical masks may convey additional protection from SARS-CoV-2 for HCW with frequent exposure to COVID-19 patients.
Calcined Attapulgite Clay as Supplementary Cementing Material: Thermal Treatment, Hydration Activity and Mechanical Properties
Authors: Shi Tao , Liu Yanming , Zhang Yanlin , Lan Yingjia , Zhao Qifan , Zhao Yujing , Wang Haobo 
Published: February 2022

AbstractThe present paper studied the effects of calcination temperatures (200–800 °C) on the appearance, mineral composition, and active SiO2 content in attapulgite and investigated the effects of attapulgite before and after calcination on the chemically bonded water content, the degree of reaction of cement paste, and the mechanical properties such as the flexural strength, compressive strength, and splitting-tensile strength of cement mortar. The results indicate that the calcination temperature changes the mineral composition of attapulgite, thereby affecting the hydration activity of cement-based materials. The attapulgite calcined at 500 °C (AT500) has the best enhancement on the hydration activity of cement-based materials. The calcination at 500 °C is most beneficial to the dissolution of SiO2, and the content of SiO2 reaches 20.96%. The contents of chemically bonded water in the samples incorporated with calcined attapulgite reduced and that of the samples incorporated with AT500 at 28 d is the same as that of the control group. The reaction degree of AT500 is 78.61% at 28 days. Calcined attapulgite clay can reduce the energy consumption of the cement industry and promote the sustainable development of attapulgite clay.
Routine and preventive health care use in the community among women sentenced to probation
Authors: Lorvick Jennifer , Hemberg Jordana L. , Browne Erica N. , Comfort Megan L. 
Published: February 2022

Abstract
Background
Women involved in the criminal legal (CL) system in the United States have much higher levels of chronic and infectious illness than women in the general population. Over 80% of women in the CL system are on community supervision, which means they receive health care in community settings. While the use of Emergency Department care among CL involved populations has been examined fairly extensively, less is known about engagement in routine and preventive medical care among people on community supervision.

Methods
We conducted a longitudinal study of health care utilization among women with Medicaid who were currently or previously sentenced to probation in Alameda County, CA (N = 328). At baseline, 6- and 12-months, we interviewed participants about every medical care visit in the six months prior, and about potential influences on health care utilization based on the Behavioral Model for Vulnerable Populations (BMVP). Associations between BMVP factors and utilization of routine or preventive care were estimated using Poisson regression models with robust standard errors. Generalized estimating equations (GEE) were used account for repeated measures over time.

Results
A diagnosis of one or more chronic illnesses was reported by 82% of participants. Two-thirds (62%) of women engaged in routine or preventive care in the six months prior to interview. A quarter of women engaging in routine or preventive care did not have a primary care provider (PCP). Having a PCP doubled the likelihood of using routine or preventive care (adjusted Relative Risk [adjRR] 2.27, p < 0.001). Subsistence difficulty (adjRR 0.74, p = 0.01) and unmet mental health care need (adjRR 0.83, p = 0.001) were associated with a lower likelihood of using routine or preventive care.

Conclusion
Findings underscore the importance of meeting the basic needs of women on community supervision and of connecting them with primary health care providers.
Landscape characteristics influence ranging behavior of Asian elephants at the human-wildlands interface in Myanmar
Authors: Chan A. N. , Wittemyer G. , McEvoy J. , Williams A. C. , Cox N. , Soe P. , Grindley M. , Shwe N. M. , Chit A. M. , Oo Z. M. , Leimgruber P. 
Published: February 2022

AbstractContextAsian elephant numbers are declining across much of their range driven largely by serious threats from land use change resulting in habitat loss and fragmentation. Myanmar, holding critical range for the species, is undergoing major developments due to recent sociopolitical changes. To effectively manage and conserve the remaining populations of endangered elephants in the country, it is crucial to understand their ranging behavior.ObjectivesOur objectives were to (1) estimate the sizes of dry, wet, and annual ranges of wild elephants in Myanmar; and quantify the relationship between dry season (the period when human-elephant interactions are the most likely to occur) range size and configurations of agriculture and natural vegetation within the range, and (2) evaluate how percentage of agriculture within dry core range (50% AKDE range) of elephants relates to their daily distance traveled.MethodsWe used autocorrelated kernel density estimator (AKDE) based on a continuous-time movement modeling (ctmm) framework to estimate dry season (26 ranges from 22 different individuals), wet season (12 ranges from 10 different individuals), and annual range sizes (8 individuals), and reported the 95%, 50% AKDE, and 95% Minimum Convex Polygon (MCP) range sizes. We assessed how landscape characteristics influenced range size based on a broad array of 48 landscape metrics characterizing aspects of vegetation, water, and human features and their juxtaposition in the study areas. To identify the most relevant landscape metrics and simplify our candidate set of informative metrics, we relied on exploratory factor analysis and Spearman’s rank correlation coefficient. Based on this analysis we adopted a final set of metrics into our regression analysis. In a multiple regression framework, we developed candidate models to explain the variation in AKDE dry season range sizes based on the previously identified, salient metrics of landscape composition.ResultsElephant dry season ranges were highly variable averaging 792.0 km2and 184.2 km2for the 95% and 50% AKDE home ranges, respectively. We found both the shape and spatial configuration of agriculture and natural vegetation patches within an individual elephant’s range play a significant role in determining the size of its range. We also found that elephants are moving more (larger energy expenditure) in ranges with higher percentages of agricultural area.ConclusionOur results provide baseline information on elephant spatial requirements and the factors affecting them in Myanmar. This information is important for advancing future land use planning that takes into account space-use requirements for elephants. Failing to do so may further endanger already declining elephant populations in Myanmar and across the species’ range.
Hereditary oral squamous cell carcinoma associated with CDKN2A germline mutation: A case report
Authors: Jeong Ah-Reum , Forbes Kimberly , Orosco Ryan K. , Cohen Ezra E. W. 
Published: February 2022

Background Germline CDKN2A mutations are a well-known cause of familial atypical multiple mole melanoma (OMIM #155601) and melanoma-pancreatic cancer syndrome (OMIM #606719). Increased risk of head and neck squamous cell carcinoma (HNSCC), particularly oral squamous cell carcinoma (OSCC) in those with germline CDKN2A mutations, has been described. However, screening for HNSCC is not a routine practice in patients with CDKN2A germline mutations and these mutations are not a conventional test for HNSCC patients without obvious risk factors. Case presentation We describe a female with no smoking history who developed oral squamous cell carcinoma at age 39 and had a complex clinical course of recurrent multifocal squamous cell carcinoma (SCC) and carcinoma in situ of the oral cavity and oropharynx. Detailed family history demonstrated that her mother was diagnosed with OSCC and melanoma in her 40 s, and her maternal grandfather was diagnosed with metastatic melanoma in his 40 s. Genetic testing of the patient and her mother revealed CDKN2A c.301G>T mutation. She was referred to genetic counseling as well as to dermatology, gastroenterology, and neurology for cancer surveillance. She was treated with resections and has no evidence of disease 3 years after diagnosis. Conclusions We report a family with a CDKN2A c.301 G>T mutation who also have significant history of OSCC, adding to the growing body of literature suggesting increased risk of HNSCC, particularly OSCC, in CDKN2A germline mutation carriers. It is important to consider CDKN2A mutation testing in familial HNSCC and young patients without obvious risk factors. Moreover, surveillance for HNSCC should be routine practice in those with a CDKN2A germline mutation. Graphical abstract
Normal range of motion at the hip show different pressure behavior in the lateral and acetabular compartments: a cadaveric investigation
Authors: St-Pierre Marc-Olivier , Lavoie Félix-Antoine , Hoffmann Marion , Begon Mickaël , Bertrand-Grenier Antony , Sobczak Stéphane 
Published: February 2022

Abstract
Purpose
The techniques used previously to assess intracapsular pressures did not allow the assessment of pressure variations in both compartments throughout the entire range of motion without puncturing the capsular tissue. Our hypothesis was that the intra-capsular pressure would be different in the lateral and acetabular compartment depending on the movement assessed.

Methods
Eight hip joints from four cadaveric specimens (78.5 ± 7.9 years) were assessed using intra-osseous tunnels reaching the lateral and acetabular compartments. Using injector adaptors, 2.7 ml of liquid were inserted in both compartments to simulate synovial liquid. Optic pressure transducers were used to measure pressure variations. We manually performed hip adduction, abduction, extension, flexion and internal rotation at 90° of flexion.

Results
Hip extension and internal rotation show the highest intra-capsular pressures in the lateral compartment with increases of 20.56 ± 19.29 and 19.27 ± 18.96 mmHg, respectively. Hip abduction and hip internal rotation showed depressurisations of − 16.86 ± 18.01 and − 31.88 ± 30.71 mmHg in the acetabular compartment, respectively. The pressures measured in the lateral compartment and in the acetabular compartment were significantly (P < 0.05) different for the hip abduction, 90° of flexion and internal rotation. Pressure variations showed that maximum intracapsular fluid pressures in the lateral compartment occur at maximum range of motion for all movements.

Conclusion
As an increase in pressure may produce hip pain, clinician should assess pain at maximum range of motion in the lateral compartment. The pressure measured in the acetabular compartment vary depending on the hip position. The movements assessed are used in clinical practice to evaluate hip integrity and might bring pain. The pressure variations throughout the entire range of motion are a relevant information during hip clinical assessment and might help clinicians to better understand the manifestations of pain.
Performance evaluation of the IRIS XL-220 PET/CT system, a new camera dedicated to non-human primates
Authors: Boisson Frédéric , Serriere Sophie , Cao Liji , Bodard Sylvie , Pilleri Alessandro , Thomas Lionel , Sportelli Giancarlo , Vercouillie Johnny , Emond Patrick , Tauber Clovis , Belcari Nicola , Lefaucheur Jean-Luc , Brasse David , Galineau Laurent 
Published: February 2022

AbstractBackgroundNon-human primates (NHP) are critical in biomedical research to better understand the pathophysiology of diseases and develop new therapies. Based on its translational and longitudinal abilities along with its non-invasiveness, PET/CT systems dedicated to non-human primates can play an important role for future discoveries in medical research. The aim of this study was to evaluate the performance of a new PET/CT system dedicated to NHP imaging, the IRIS XL-220 developed by Inviscan SAS. This was performed based on the National Electrical Manufacturers Association (NEMA) NU 4-2008 standard recommendations (NEMA) to characterize the spatial resolution, the scatter fraction, the sensitivity, the count rate, and the image quality of the system. Besides, the system was evaluated in real conditions with two NHP with18F-FDG and (-)-[18F]FEOBV which targets the vesicular acetylcholine transporter, and one rat using18F-FDG.ResultsThe full width at half maximum obtained with the 3D OSEM algorithm ranged between 0.89 and 2.11 mm in the field of view. Maximum sensitivity in the 400–620 keV and 250–750 keV energy windows were 2.37% (22 cps/kBq) and 2.81% (25 cps/kBq), respectively. The maximum noise equivalent count rate (NEC) for a rat phantom was 82 kcps at 75 MBq and 88 kcps at 75 MBq for energy window of 250–750 and 400–620 keV, respectively. For the monkey phantom, the maximum NEC was 18 kcps at 126 MBq and 19 kcps at 126 MBq for energy window of 250–750 and 400–620 keV, respectively. The IRIS XL provided an excellent quality of images in non-human primates and rats using18F-FDG. The images acquired using (-)-[18F]FEOBV were consistent with those previously reported in non-human primates.ConclusionsTaken together, these results showed that the IRIS XL-220 is a high-resolution system well suited for PET/CT imaging in non-human primates.
Might Gendering Ski Binding Settings be Helpful for the Prevention of ACL Injuries Among Female Recreational Alpine Skiers?
Authors: Posch Markus , Ruedl Gerhard , Tecklenburg Katja , Burtscher Martin 
Published: February 2022

AbstractWhen interpreting sex differences in the injury risk during sport activities, potential gender effects are often overlooked. This might actually be the case with regard to the higher injury risk of the anterior cruciate ligament (ACL) in female skiers. A higher failure rate of ski binding releases has been suggested at least partly to explain the more frequent ACL injuries in female skiers. However, as males seem to be predominantly responsible for the development of standards for ski binding settings, one might speculate that they could rather make standards for males than females. If true, the inclusion of female engineers could actually represent an appropriate approach to reduce ACL injures in female recreational skiers.
Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered
circPRMT5
siRNA
Authors: Yu Chunping , Zhang Yi , Wang Ning , Wei Wensu , Cao Ke , Zhang Qun , Ma Peiying , Xie Dan , Wu Pei , Liu Biao , Liu Jiahao , Xiang Wei , Hu Xing , Liu Xuewen , Xie Jianfei , Tang Jin , Long Zhi , Wang Long , Zeng Hongliang , Liu Jianye 
Published: February 2022

Abstract

Background

Circular RNAs (circRNAs) have important functions in many fields of cancer biology. In particular, we previously reported that the oncogenic circRNA,
circPRMT5
, has a major role in bladder cancer progression. Therapy based on circRNAs have good prospects as anticancer strategies. While anti-circRNAs are emerging as therapeutics, the specific in vivo delivery of anti-circRNAs into cancer cells has not been reported and remains challenging.

Methods
Synthesized chrysotile nanotubes (SCNTs) with a relatively uniform length (~ 200 nm) have been designed to deliver an siRNA against the oncogenic circPRMT5 (si-circPRMT5) inhibit circPRMT5. In addition, the antitumor effects and safety evaluation of SCNTs/si-circPRMT5 was assessed with a series of in vitro and in vivo assays.

Results

The results showed that SCNTs/si-circPRMT5 nanomaterials prolong si-circPRMT5’s half-life in circulation, enhance its specific uptake by tumor cells, and maximize the silencing efficiency of
circPRMT5
. In vitro, SCNTs encapsulating si-circPRMT5 could inhibit bladder cancer cell growth and progression. In vivo, SCNTs/si-circPRMT5 inhibited growth and metastasis in three bladder tumor models (a subcutaneous model, a tail vein injection lung metastatic model, and an in situ model) without obvious toxicities. Mechanistic study showed that SCNTs/si-circPRMT5 regulated the miR-30c/SNAIL1/E-cadherin axis, inhibiting bladder cancer growth and progression.

Conclusion
The results highlight the potential therapeutic utility of SCNTs/si-circPRMT5 to deliver si-circPRMT5 to treat bladder cancer.
The impact of maritime transport financing on total trade in South Africa
Authors: Matekenya W. , Ncwadi R. 
Published: February 2022

AbstractThe study explored the impact of maritime transport financing on trade in South Africa. Using the Autoregressive Distribution lag model, we examine the impact of maritime transport financing on total trade in South Africa during the period 1994 to 2019. The results confirm a long and short-run positive relationship between maritime transport financing and total trade. The findings suggest an overall, substantial investment in maritime transport has the potential to promote trade flows in South Africa. We recommend more investments towards maritime transport infrastructure to ensure a significant increase in exports, and to stimulate economic development in South Africa.
Do COVID-19 containment measures work? Evidence from Switzerland
Authors: Pleninger Regina , Streicher Sina , Sturm Jan-Egbert 
Published: February 2022

AbstractWe study the interplay of non-pharmaceutical containment measures, human behavior, and the spread of COVID-19 in Switzerland. First, we collect sub-national data and construct indices that capture the stringency of containment measures at the cantonal level. Second, we use a vector autoregressive model to analyze feedback effects between our variables of interest via structural impulse responses. Our results suggest that increases in the stringency of containment measures lead to a significant reduction in weekly infections as well as debit card transactions, which serve as a proxy for behavioral changes in the population. Furthermore, analyzing different policy measures individually shows that business closures, recommendations to work from home, and restrictions on gatherings have been particularly effective in containing the spread of COVID-19 in Switzerland. Finally, our findings indicate a sizeable voluntary reduction in debit card transactions in response to a positive infection shock.
Relation between Helicoverpa armigera (Hubner) (Lepidoptera/Noctuidae) mortality and entomopathogenic fungi persistence in soybean leaflets
Authors: de Souza Tamires Doroteo , Fernandes Fabricio Oliveira , Sanches Ariadne Costa , do Nascimento Joacir , Pinto Antonio Alves , Polanczyk Ricardo Antônio 
Published: February 2022

Abstract
​Background
Entomopathogenic fungi have low persistence in the field because of UV light, high temperatures and low humidity. Thus, this study's objective was to correlate the persistence of Beauveria bassiana and Metarhizium anisopliae in soybean leaf by measuring the mortality and sub-lethal effects of Helicoverpa armigera (Hubner) (Lepidoptera/Noctuidae). In the 2017–2018 and 2019–2020 soybean seasons, the experiments were conducted on plots subdivided in a completely randomized design. After spraying each plot with the fungal, either B. bassiana or M. anisopliae, leaves were collected hourly for 8 h after application and transferred to the laboratory. The local air temperature was recorded each time. For persistence assessment, the fungal suspension was prepared from the leaf disks; thereafter, 150 µl of the suspension was removed and poured into a plate. After 72 h of inoculation, colony-forming units (CFUs) were counted. For the mortality test, the leaf disks were placed individually in pots and offered to second instar larvae of H. armigera. The surviving larvae were evaluated for sub-lethal effects and biological parameters.

Results
Beauveria bassiana was more persistent than M. anisopliae, which persisted for 3 h in the first year and 5 h in the second year when temperatures were milder; B. bassiana persisted throughout the evaluation period (8 h). The mortality of H. armigera decreased with an increase in the time since application fungal suspension, presenting a range of 86–30% for B. bassiana and 78–4.2% for M. anisopliae.

Conclusion
Assessments of sublethal effects showed an inverse correlation between CFUs and parameters such as fertility and weight.
Whole lung lavage in pulmonary alveolar proteinosis: anesthetic management and challenges
Authors: Manohar Manisha , Bansal Priyanka 
Published: February 2022

Abstract
Background
Pulmonary alveolar proteinosis is a rare disorder characterized by alveolar obstruction secondary to the collection of lipoproteinaceous material in the alveoli leading to a spectrum of respiratory illness ranging from mild to severe respiratory failure. Whole lung lavage considered the gold standard for the treatment of PAP is performed under general anesthesia and presents a unique set of challenges to the anesthesiologist. The procedure involves manually removing the lipoproteinacious material by repeating aliquots of fluids and draining periodically after percussion. When done effectively it is quite effective and life-saving procedure.

Case presentation
A 39-year-old female presented with history of gradually progressive shortness of breath, diagnosed to have primary pulmonary alveolar proteinosis for which bilateral whole lung lavage was planned. During the lavage cycles, patient had episodes of desaturation to 60% during which the double lung ventilation was resumed. Her serial ABG revealed a deteriorating oxygenation. In view of increased oxygen requirements, the procedure was carried out in two stages. She made a complete recovery after the procedure.

Conclusions
A multidisciplinary team working with good communication, use of adequate back up plans, meticulous lung separation with double lumen tube, vigilant intraoperative monitoring, short-term postoperative ventilation go a long way in achieving adequate gas exchange in patients with respiratory failure due to pulmonary alveolar proteinosis.