bluuebunny/crossref_metadata_2025_split huggingface dataset:
“I was a soccer mom—high or not”: The intersecting roles of parenting and recovery
Authors: Day Elizabeth , Mihalec‐Adkins Brittany P. , Morrissey Mary Beth , Vescia Francesca , Tach Laura 
Published: October 2022

AbstractObjectiveThe overarching goal of this study was to analyze qualitatively how parents in a state‐mandated family treatment court (FTC) intervention revised and performed their parental role while navigating a novel recovery role.BackgroundA large proportion of parents are involved with the child welfare system for reasons related to substance misuse. Prior literature makes clear that navigating child welfare interventions is incredibly challenging given the many requirements and expectations parents must meet to resume parenting without state oversight. No work to date has explored the role strain arguably inherent to the experience of being tasked with simultaneously revising the parental role and adopting and performing a new recovery role in the context of nonvoluntary state intervention.MethodData came from transcripts of in‐depth, semistructured interviews with 21 parents who were former participants in FTC. Interview questions were designed to elicit rich, personal narratives, with probes for concrete examples wherever possible.ResultsVariation in parents' role definitions and trajectories of both parental and recovery role performance were used to develop a typology of roles: role enactors, role revisors, and role rejectors. The three groups differed in how closely their views around substance misuse, parenting, and recovery aligned with the role expectations put forth by the state, leading to varying degrees of role strain and conflict across groups.ConclusionFindings shed light on the experiences of parents involuntarily participating in both child protective interventions and substance use treatment—a growing proportion of parents that have been largely ignored in prior literature.
The fall of the summer truffle: Recurring hot, dry summers result in declining fruitbody production of Tuber aestivum in Central Europe
Authors: Steidinger Brian S. , Büntgen Ulf , Stobbe Uli , Tegel Willy , Sproll Ludger , Haeni Matthias , Moser Barbara , Bagi István , Bonet José‐Antonio , Buée Marc , Dauphin Benjamin , Martínez‐Peña Fernando , Molinier Virginie , Zweifel Roman , Egli Simon , Peter Martina 
Published: October 2022

AbstractGlobal warming is pushing populations outside their range of physiological tolerance. According to the environmental envelope framework, the most vulnerable populations occur near the climatic edge of their species' distributions. In contrast, populations from the climatic center of the species range should be relatively buffered against climate warming. We tested this latter prediction using a combination of linear mixed effects and machine learning algorithms on an extensive, citizen‐scientist generated dataset on the fruitbody productivity of the Burgundy (aka summer) truffle (Tuber aestivum Vittad.), a keystone, ectomycorrhizal tree‐symbiont occurring on a wide range of temperate climates. T. aestivum's fruitbody productivity was monitored at 3‐week resolution over up to 8 continuous years at 20 sites distributed in the climatic center of its European distribution in southwest Germany and Switzerland. We found that T. aestivum fruitbody production is more sensitive to summer drought than would be expected from the breadth of its species' climatic niche. The monitored populations occurring nearly 5°C colder than the edge of their species' climatic distribution. However, interannual fruitbody productivity (truffle mass year−1) fell by a median loss of 22% for every 1°C increase in summer temperature over a site's 30‐year mean. Among the most productive monitored populations, the temperature sensitivity was even higher, with single summer temperature anomalies of 3°C sufficient to stop fruitbody production altogether. Interannual truffle productivity was also related to the phenology of host trees, with ~22 g less truffle mass for each 1‐day reduction in the length of the tree growing season. Increasing summer drought extremes are therefore likely to reduce fruiting among summer truffle populations throughout Central Europe. Our results suggest that European T. aestivum may be a mosaic of vulnerable populations, sensitive to climate‐driven declines at lower thresholds than implied by its species distribution model.
Migraine and infertility, merging concepts in women's reproductive health: A narrative review
Authors: Harpe Jasmin , Bernstein Carolyn , Harriott Andrea 
Published: October 2022

AbstractObjectiveThe objective is to examine issues around treating infertility in patients with migraine.BackgroundWomen outnumber men in migraine diagnosis with a 3:1 ratio; the disease is commonly expressed in women of child‐bearing age and is influenced by changes in circulating hormones. Infertility is also common, and the use of treatment options, such as assisted reproductive technology, have expanded exponentially in recent years.MethodsWe summarized the literature around the effect of infertility treatments on headache in the general population and migraine population. We also discuss sociobehavioral, economic, and biological factors affecting fertility in patients with migraine, describe infertility protocols, and propose areas of focus for future research. We searched PubMed for the combined key terms in vitro fertilization or assisted reproductive technology AND migraine, or headache. The search included all dates and specified English‐language results only.ResultsMigraine may negatively influence family planning and fertility. Patients face obstacles stemming from the impact of migraine on social relationships and the interference of preventive medications on pregnancy. Migraine may also be associated with an increased prevalence of endocrine disorders which in turn affect fertility. Moreover, infertility treatments are associated with mild headache as a side effect. In addition, we found only one retrospective study demonstrating an increase in headache frequency during in vitro fertilization in the migraine population.ConclusionsWe determined that there is little research focused specifically on migraine headache exacerbation and other migraine‐associated health outcomes with infertility treatment. This topic merits further interdisciplinary exploration.
Undergraduate dental students' perception of paediatric dental teaching in an urban and rural Australian dental school
Authors: Hossain Nadeem , Kaur Harmeet , Mohanasundaram Divyadarshini , Calache Hanny , Zafar Sobia 
Published: October 2022

AbstractBackgroundConfidence in performing paediatric dental treatment is important as it ensures better oral health outcomes in the patient's adulthood.AimTo investigate the confidence and attitudes of final year dentistry students, attending an urban and rural dental programme, towards their paediatric dentistry training.DesignA questionnaire was distributed to final year dentistry students at the urban‐based university, The University of Queensland, and at the rural‐based university, La Trobe University. The questionnaire collected information using 5‐point Likert scale and short‐answer questions, which explored the theoretical, observational, preclinical and clinical aspects of students' paediatric dentistry training. Jamovi and GraphPad Prism were used for data analysis and the creation of graphs.ResultsThe questionnaire was completed by 32 rural students and 47 urban students, with a response rate of 79%. Rural students were found to be less confident with the theory on restorative procedures than urban students. Observations of a dentist performing treatment on child were completed by a significantly larger proportion of urban students (70.2%) than rural students (46.9%). Students from both universities reported to have developed the least confidence in the preclinical training of pulp therapies and expressed the need for additional preclinical sessions for more training. At both universities, students indicated they were the least confident in the clinical practice of pulp therapies and management of traumatic dental injuries. Urban students were found to be more confident than their rural counterparts in the clinical practice of examination, treatment planning and preventative procedures, as well as in restorative procedures.ConclusionsBoth urban and rural students were found to have the least confidence in preclinical and clinical skills related to pulp therapies. Restorative dentistry was an area in which urban students were significantly more confident than rural students in both the theoretical and the clinical aspects.
A nomogram for accurately predicting the surgical site infection following transforaminal lumbar interbody fusion in type 2 diabetes patients, based on glycemic variability
Authors: Liu Hang , Zhang Wei , Hu Qiang , Liu Lei , Xie Zhiyang , Xu Yuzhu , Jing Genyang , Wang Yuntao 
Published: October 2022

AbstractSurgical site infection (SSI) is a common and serious complication of transforaminal lumbar interbody fusion (TLIF), and the occurrence of SSI usually leads to prolonged hospitalisation, increased medical costs, poor prognosis, and even death. The objectives of this study were to compare the incidence of SSI in patients with type 2 diabetes, investigate the correlation between perioperative glycemic variability and postoperative SSI, and develop a nomogram model to predict the risk of SSI. This study retrospectively analysed 339 patients with type 2 diabetes who underwent TLIF in the spinal surgery department of the Affiliated Zhongda Hospital of Southeast University from January 2018 to September 2021. The medical records of all patients were collected, and postoperative infection cases were determined according to the diagnostic criteria of surgical site infection. The risk factors for postoperative SSI were analysed by univariate and multivariate logistic regression. And Nomogram prediction model was established and validated. The nomogram incorporated seven independent predictors. Preoperative FPG‐CV was the most important independent risk predictor of SSI, followed by preoperative MFBG, duration of drain placement, postoperative FPG‐CV, preoperative blood glucose control scheme, duration of diabetes >5 years, and the number of fused vertebrae ≥2. The nomogram showed good diagnostic accuracy for the SS of both the training cohort and the validation cohort (AUC = 0.915 and AUC = 0.890). The calibration curves for the two cohorts both showed optimal agreement between nomogram prediction and actual observation. In conclusion, preoperative and postoperative glycemic variability is closely related to the occurrence of SSI. We developed and validated a nomogram to accurately predict the risk of SSI after TLIF surgery. It's helpful for spinal surgeons to formulate reasonable treatment plans and prevention strategies for type 2 diabetes patients.
Association of vitamin D status withall‐causemortality and outcomes among Chinese individuals with diabetic foot ulcers
Authors: Tang Weiwei , Chen Lihong , Ma Wanxia , Liu Guanjian , Chen Dawei , Wang Chun , Gao Yun , Ran Xingwu 
Published: October 2022

AbstractAims/IntroductionThe aim of this study was to examine the correlation between serum vitamin D concentrations and prognosis among Chinese individuals with diabetic foot ulcers (DFUs).Materials and MethodsWe retrospectively recruited 488 adults with DFUs in West China Hospital from 1 January 2012 to 31 December 2019. After telephone follow up, 275 patients were finally included. We compared serum vitamin D concentrations among DFUs patients with different prognostic status, and examined the association of vitamin D status with prognostic variables by Kaplan–Meier analysis. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals for all‐cause mortality.ResultsThe median concentration of serum vitamin D of patients with DFUs was 37.78 nmol/L (interquartile range 27.91–50.66 nmol/L), with 31.6% having vitamin D deficiency (<30 nmol/L) and 42.2% having insufficient vitamin D (<50 nmol/L). During a median follow‐up period of 52 months, 65 patients died, with an all‐cause mortality of 23.64%. Vitamin D deficiency was independently linked to increased all‐cause mortality after multivariable adjustments (hazard ratio 0.565, 95% confidence interval 0.338–0.946,P = 0.030). There were no significant differences between vitamin D concentrations and other outcomes of DFUs. Patients who suffered amputations had a tendency of lower vitamin D concentrations (34.00 [interquartile range 26.90–41.81] vs 40.21 [interquartile range 29.60–53.96] nmol/L,P = 0.053).ConclusionsVitamin D deficiency was significantly associated with increased all‐cause mortality in Chinese individuals with DFUs. Vitamin D supplementation might be a potential therapy for DFUs to prevent premature death and improve outcomes.
Sex differences in predictive factors for onset of type 2 diabetes in Japanese individuals: A 15‐year follow‐up study
Authors: Yoshimoto Mei , Sakuma Yukie , Ogino Jun , Iwai Rie , Watanabe Saburo , Inoue Takeshi , Takahashi Haruo , Suzuki Yoshifumi , Kinoshita Daisuke , Takemura Koji , Takahashi Hidenori , Shimura Haruhisa , Babazono Tetsuya , Yoshida Shouji , Hashimoto Naotake 
Published: October 2022

AbstractAims/IntroductionThe increase in the number of patients with type 2 diabetes mellitus is an important concern worldwide. The goal of this study was to investigate factors involved in the onset of type 2 diabetes mellitus, and sex differences in long‐term follow up of people with normal glucose tolerance.Materials and MethodsOf 1,309 individuals who underwent screening at our facility in 2004, 748 individuals without diabetes were enrolled. Correlations of metabolic markers including serum adiponectin (APN) with onset of type 2 diabetes mellitus were examined over 15 years in these individuals.ResultsThe Kaplan–Meier curve for onset of type 2 diabetes mellitus for 15 years in the decreased APN group was examined. Hazard ratios for the APN concentration for onset of diabetes were 1.78 (95% confidence interval [CI] 1.20–2.63, P = 0.004) in all participants, 1.48 (95% CI 0.96–2.29, P = 0.078) for men and 3.01 (95% CI 1.37–6.59, P = 0.006) for women. During the follow‐up period of 15 years, body mass index, estimated glomerular filtration rate, fatty liver, C‐reactive protein and alanine aminotransferase in men were significant in univariate analysis, but only estimated glomerular filtration rate and fatty liver were significantly related to onset of type 2 diabetes mellitus in multivariate analysis. In women, body mass index, systolic blood pressure, triglyceride, fatty liver and APN were significant in univariate analysis, and APN was the only significant risk factor in multivariate analysis (P < 0.05).ConclusionsThere are differences between men and women with regard to targets for intervention to prevent the onset of type 2 diabetes mellitus. Individuals requiring intensive intervention should be selected with this finding to maximize the use of limited social and economic resources.
Design and evaluation of a community and impact‐based site‐specific early warning system (SS‐EWS): The SS‐EWS framework
Authors: Meléndez‐Landaverde Erika R. , Sempere‐Torres Daniel 
Published: October 2022

AbstractThe recent extreme rainfall events in Spain such as the storm Gloria have highlighted the gaps in emergency communication, particularly the disconnect between the available impact‐based early warning systems (IBEWSs) and the steps communities take during emergencies. This paper presents a community‐centred framework named ‘site‐specific early warning system’ (SS‐EWS) to co‐design and co‐evaluate with communities an IBEWS for vulnerable locations within high‐risk areas. The components of the framework guide communities in identifying and evaluating local impacts; establishing impact and advisory tables; deriving impact‐based rainfall thresholds and warning levels; and configuring the SS‐EWS with radar‐based nowcasting and numerical weather prediction (NWP) models. A first implementation and evaluation of the SS‐EWS have been done for a public school, two ford crossings and the city of Terrassa, Spain. The SS‐EWS shows promising results in triggering location‐based or site‐specific warnings compatible with the reported impacts and proposing actions to reduce the local risk. Furthermore, the combination of NWP and radar‐based nowcasting improved the capacity of the SS‐EWS to monitor the evolution of the precipitation and capture highly intense rainfall. The SS‐EWS can be a straightforward and cost‐efficient complement for regional EWS to increase the preparedness of communities.
Age‐dependent effects of diabetes and obesity on liver‐related events in non‐alcoholic fatty liver disease: Subanalysis of CLIONE in Asia
Authors: Seko Yuya , Kawanaka Miwa , Fujii Hideki , Iwaki Michihiro , Hayashi Hideki , Toyoda Hidenori , Oeda Satoshi , Hyogo Hideyuki , Morishita Asahiro , Munekage Kensuke , Kawata Kazuhito , Yamamura Sakura , Sawada Koji , Maeshiro Tatsuji , Tobita Hiroshi , Yoshida Yuichi , Naito Masafumi , Araki Asuka , Arakaki Shingo , Kawaguchi Takumi , Noritake Hidenao , Ono Masafumi , Masaki Tsutomu , Yasuda Satoshi , Tomita Eiichi , Yoneda Masato , Tokushige Akihiro , Kamada Yoshihiro , Takahashi Hirokazu , Ueda Shinichiro , Aishima Shinichi , Sumida Yoshio , Okanoue Takeshi , Itoh Yoshito , Nakajima Atsushi ,   Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG‐NAFLD)
Published: October 2022

AbstractBackground and AimOlder age, type 2 diabetes mellitus (T2DM), and obesity are known risk factors for liver‐related events (LREs). We investigated the impacts of T2DM and obesity on LRE according to age in Japanese patients with non‐alcoholic fatty liver disease (NAFLD).MethodsWe performed a subanalysis of a retrospective cohort study (CLIONE in Asia), including 1395 patients with biopsy‐proven NAFLD. The median follow‐up was 4.6 years.ResultsThe median age was 57 years, and 36.2% had T2DM. The median body mass index (BMI) was 27.4, and 28.5% were severely obese (BMI ≥ 30). During follow‐up, 37 patients developed hepatocellular carcinoma (HCC), and 58 patients developed LRE. In patients younger than 65 years, advanced fibrosis (hazard ratio [HR] 7.69, P < 0.001) and T2DM (HR 3.37, P = 0.017) were HCC risk factors, and advanced fibrosis (HR 9.40, P < 0.001) and T2DM (HR 2.51, P = 0.016) were LRE risk factors. In patients 65 years and older, advanced fibrosis (HR 4.24, P = 0.010) and obesity (HR 4.60, P = 0.006) were HCC risk factors, and advanced fibrosis (HR 4.22, P = 0.002) and obesity (HR 4.22, P = 0.002) were LRE risk factors.ConclusionType 2 diabetes mellitus and obesity contributed to LRE in younger and older patients, respectively, along with advanced fibrosis. Therefore, controlling T2DM in patients younger than 65 years and controlling weight in patients 65 years and older could prevent LRE. The development of age‐dependent screening and management strategies is necessary for patients with NAFLD.
Implementation of an evidence‐based accidental tracheostomy dislodgement bundle in a community hospital critical care unit
Authors: Jung Dawn Ta Un , Grubb Lisa , Moser Chandler H. , Nazarian Jeanette T. M. , Patel Neesha , Seldon Lisa E. , Moore Kristin A. , McGrath Brendan A. , Brenner Michael J. , Pandian Vinciya 
Published: October 2022

AbstractBackgroundTracheostomy dislodgment can lead to catastrophic neurological injury or death. A fresh tracheostomy amplifies the risk of such events, where an immature tract predisposes to false passage. Unfortunately, few resources exist to prepare healthcare professionals to manage this airway emergency.AimTo create and implement an accidental tracheostomy dislodgement (ATD) bundle to improve knowledge and comfort when responding to ATD.Materials & MethodsA multidisciplinary team with expertise in tracheostomy developed a 3‐part ATD bundle including (1) Tracheostomy Dislodgement Algorithm, (2) Head of Bed Tracheostomy Communication Tool and (3) Emergency Tracheostomy Kit. The team tested the bundle during the COVID‐19 pandemic in a community hospital critical care unit with the engagement of nurses and Respiratory Care Practitioners. Baseline and post‐implementation knowledge and comfort levels were measured using Dorton's Tracheotomy Education Self‐Assessment Questionnaire, and adherence to protocol was assessed. Reporting follows the revised Standards for Quality Improvement Reporting Excellence (SQUIRE).ResultsTwenty‐four participants completed pre‐test and post‐test questionnaires. The median knowledge score on the Likert scale increased from 4.0 (IQR = 1.0) pre‐test to 5.0 (IQR = 1.0) post‐test. The median comfort level score increased from 38.0 (IQR = 7.0) pre‐test to 40.0 (IQR = 5.0) post‐test). In patient rooms, adherence was 100% for the Head of Bed Tracheostomy Communication Tool and Emergency Tracheostomy Kit. The adherence rate for using the Dislodgement Algorithm was 55% in ICU and 40% in SCU.DiscussionThis study addresses the void of tracheostomy research conducted in local community hospitals. The improvement in knowledge and comfort in managing ATD is reassuring, given the knowledge gap among practitioners demonstrated in prior literature. The ATD bundle assessed in this study represents a streamlined approach for bedside clinicians – definitive management of ATD should adhere to comprehensive multidisciplinary guidelines.ConclusionsATD bundle implementation increased knowledge and comfort levels with managing ATD. Further studies must assess whether ATD bundles and other standardised approaches to airway emergencies reduce adverse events.Relevance to Clinical PracticeA streamlined intervention bundle employed at the unit level can significantly improve knowledge and comfort in managing ATD, which may reduce morbidity and mortality in critically ill patients with tracheostomy.
Cellular communication network factor 1 interlinks autophagy and ERK signaling to promote osteogenesis of periodontal ligament stem cells
Authors: Li Zixuan , Wu Zuping , Xi Xun , Zhao Fang , Liu Hong , Liu Dongxu 
Published: October 2022

AbstractObjectivesTo investigate the effects of cellular communication network factor 1 (CCN1), a critical matricellular protein, on alveolar bone regeneration, and to elucidate the underlying molecular mechanism.BackgroundIn the process of orthodontic tooth movement, bone deposition on the tension side of human periodontal ligament stem cells (hPDLSCs) ensured high efficiency and long‐term stability of the treatment. The matricellular protein CCN1 is responsive to mechanical stimulation, exhibiting important tasks in bone homoeostasis. However, the role and mechanism of CCN1 on alveolar bone remodeling of hPDLSCs remains unclear.MethodsThe expression and distribution of CCN1 in rat periodontal ligament were detected by immunofluorescence staining and immunohistochemical staining. ELISA verified the secretion of CCN1 triggered by stretch loading. To examine the mineralization ability of hPDLSCs induced by CCN1, Western blotting, qRT‐PCR, ARS, and ALP staining were performed. CCK‐8 and cell migration assay were performed to detect the cell proliferation rate and the wound healing. PI3K/Akt, MAPK, and autophagy activation were examined via Western blotting and immunofluorescence.ResultsMechanical stimuli induced the release of CCN1 into extracellular environment by hPDLSCs. Knockdown of CCN1 attenuated the osteogenesis of hPDLSCs while rhCCN1 enhanced the expression of Runx2, Col 1, ALPL, and promoted the mineralization nodule formation. CCN1 activated PI3K/Akt and ERK signaling, and blockage of PI3K/Akt signaling reversed the accelerated cell migration triggered by CCN1. The enhanced osteogenesis induced by CCN1 was abolished by ERK signaling inhibitor PD98059 or autophagy inhibitor 3‐MA. Further investigation demonstrated PD98059 abrogated the activation of autophagy.ConclusionThis study demonstrated that CCN1 promotes osteogenesis in hPDLSCs via autophagy and MAPK/ERK pathway.