bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-institutional analysis of outcomes for thermosphere microwave ablation treatment of colorectal liver metastases: the SMAC study
Authors: De Cobelli Francesco , Calandri Marco , Della Corte Angelo , Sirovich Roberta , Gazzera Carlo , Della Vigna Paolo , Bonomo Guido , Varano Gianluca Maria , Maiettini Daniele , Mauri Giovanni , Camisassi Nicola , Steidler Stephanie , Ratti Francesca , Gusmini Simone , Ronzoni Monica , Aldrighetti Luca , Odisio Bruno C. , Racca Patrizia , Fonio Paolo , Veltri Andrea , Orsi Franco 
Published: January 2022

Abstract
Objectives
Oligometastatic colorectal cancer benefits of locoregional treatments but data concerning microwave ablation (MWA) are limited and interactions with systemic therapy are still debated. The aim of this study is to evaluate safety and effectiveness of Thermosphere™ MWA (T-MWA) of colorectal liver metastases (CLM) and factors affecting local tumor progression-free survival (LTPFS).

Methods
In this multi-institutional retrospective study (January 2015–September 2019), patients who underwent T-MWA for CLM were enrolled. Complications according to SIR classification were collected, primary efficacy and LTP were calculated. Analyzed variables included CLM size at diagnosis and at ablation, CLM number, ablation margins, intra-segment progression, chemotherapy before ablation (CBA), variations in size (ΔSDIA-ABL), and velocity of size variation (VDIA-ABL) between CLM diagnosis and ablation. Uni/multivariate analyses were performed using mixed effects Cox model to account for the hierarchical structure of data, patient/lesions.

Results
One hundred thirty-two patients with 213 CLM were evaluated. Complications were reported in 6/150 procedures (4%); no biliary complications occurred. Primary efficacy was achieved in 204/213 CLM (95.7%). LTP occurred in 58/204 CLM (28.4%). Six-, twelve-, and eighteen-month LTPFS were 88.2%, 75.8%, and 69.9%, respectively. At multivariate analysis, CLM size at ablation (p = 0.00045), CLM number (p = 0.046), ablation margin < 5 mm (p = 0.0035), and intra-segment progression (p < 0.0001) were statistically significant for LTPFS. ΔSDIA-ABL (p = 0.63) and VDIA-ABL (p = 0.38) did not affect LTPFS. Ablation margins in the chemo-naïve group were larger than those in the CBA group (p < 0.0001).

Conclusion
T-MWA is a safe and effective technology with adequate LTPFS rates. Intra-segment progression is significantly linked to LTPFS. CBA does not affect LTPFS. Anticipating ablation before chemotherapy may take the advantages of adequate tumor size with correct ablation margin planning.

Key Points
• Thermosphere™-Microwave ablation is a safe and effective treatment for colorectal liver metastases with no registered biliary complications in more than 200 ablations.
• Metastases size at time of ablation, intra-segment progression, and minimal ablation margin < 5 mm were found statistically significant for local tumor progression-free survival.
• Chemotherapy before ablation modifies kinetics growth of the lesions but deteriorates ablation margins and does not significantly impact local tumor progression-free survival.
Using an Automated Speech Recognition Approach to Differentiate Between Normal and Aspirating Swallowing Sounds Recorded from Digital Cervical Auscultation in Children
Authors: Frakking Thuy T. , Chang Anne B. , Carty Christopher , Newing Jade , Weir Kelly A. , Schwerin Belinda , So Stephen 
Published: January 2022

AbstractUse of machine learning to accurately detect aspirating swallowing sounds in children is an evolving field. Previously reported classifiers for the detection of aspirating swallowing sounds in children have reported sensitivities between 79 and 89%. This study aimed to investigate the accuracy of using an automatic speaker recognition approach to differentiate between normal and aspirating swallowing sounds recorded from digital cervical auscultation in children. We analysed 106 normal swallows from 23 healthy children (median 13 months; 52.1% male) and 18 aspirating swallows from 18 children (median 10.5 months; 61.1% male) who underwent concurrent videofluoroscopic swallow studies with digital cervical auscultation. All swallowing sounds were on thin fluids. A support vector machine classifier with a polynomial kernel was trained on feature vectors that comprised the mean and standard deviation of spectral subband centroids extracted from each swallowing sound in the training set. The trained support vector machine was then used to classify swallowing sounds in the test set. We found high accuracy in the differentiation of aspirating and normal swallowing sounds with 98% overall accuracy. Sensitivity for the detection of aspiration and normal swallowing sounds were 89% and 100%, respectively. There were consistent differences in time, power spectral density and spectral subband centroid features between aspirating and normal swallowing sounds in children. This study provides preliminary research evidence that aspirating and normal swallowing sounds in children can be differentiated accurately using machine learning techniques.
Difference of compliance rates for the recommendations in Japanese Guideline on Febrile Neutropenia according to respondents’ attributes: the second report on a questionnaire survey among hematology-oncology physicians and surgeons
Authors: Akiyama Nobu , Okamura Takuho , Yoshida Minoru , Kimura Shun-ichi , Yano Shingo , Yoshida Isao , Kusaba Hitoshi , Takahashi Kosuke , Fujita Hiroyuki , Fukushima Keitaro , Iwasaki Hiromichi , Tamura Kazuo , Saeki Toshiaki , Takamatsu Yasushi , Zenda Sadamoto 
Published: January 2022

Abstract
Purpose
The Japanese Society of Medical Oncology (JSMO) published a guideline (GL) on febrile neutropenia (FN) in 2017. This study aims to identify promoting factors and disincentives for complying with GL recommendations according to attributes of doctors providing chemotherapy.

Methods
A questionnaire survey was conducted with SurveyMonkey™ for physician members of the Japanese Association of Supportive Care in Cancer and relevant academic organizations. Each question had four options (always do, do in more than half of patients, do in less than half, do not at all) and a free description form. Responses were analyzed according to the respondents’ attributes.

Result
Seven hundred eighty-eight out of retrieved 801 responses were available for analysis. Multivariable analysis demonstrated that the percentage of GL users was higher among women and Japanese Society of Clinical Oncology members. The overall compliance rate was higher among women, JSMO members, and board-certified medical oncologists. Internists emphasized the significance of collecting blood cultures at FN onset, and surgeons stressed the importance of G-CSF prophylaxis. Hematologists were less likely to adhere to recommendations on risk assessment of FN by the Multinational Association of Supportive Care in Cancer score and administration of gammaglobulin products. However, those are acceptable due to the characteristics of their practice. Eight recommendations had no difference in compliance rates between users and non-users, some of whose statements were ambiguous and discretionary.

Conclusion
Women were more likely to use and adhere to GL. The recommendations should be developed considering the characteristics of specialty and subspecialty and avoiding ambiguity and discretionary statements.
Virtual reality and machine learning in the automatic photoparoxysmal response detection
Authors: Moncada Fernando , Martín Sofía , González Víctor M. , Álvarez Víctor M. , García-López Beatriz , Gómez-Menéndez Ana Isabel , Villar José R. 
Published: January 2022

AbstractPhotosensitivity, in relation to epilepsy, is a genetically determined condition in which patients have epileptic seizures of different severity provoked by visual stimuli. It can be diagnosed by detecting epileptiform discharges in their electroencephalogram (EEG), known as photoparoxysmal responses (PPR). The most accepted PPR detection method—a manual method—considered as the standard one, consists in submitting the subject to intermittent photic stimulation (IPS), i.e. a flashing light stimulation at increasing and decreasing flickering frequencies in a hospital room under controlled ambient conditions, while at the same time recording her/his brain response by means of EEG signals. This research focuses on introducing virtual reality (VR) in this context, adding, to the conventional infrastructure a more flexible one that can be programmed and that will allow developing a much wider and richer set of experiments in order to detect neurological illnesses, and to study subjects’ behaviours automatically. The loop includes the subject, the VR device, the EEG infrastructure and a computer to analyse and monitor the EEG signal and, in some cases, provide feedback to the VR. As will be shown, AI modelling will be needed in the automatic detection of PPR, but it would also be used in extending the functionality of this system with more advanced features. This system is currently in study with subjects at Burgos University Hospital, Spain.
Recurrent neural network model for high-speed train vibration prediction from time series
Authors: Siłka Jakub , Wieczorek Michał , Woźniak Marcin 
Published: January 2022

AbstractIn this article, we want to discuss the use of deep learning model to predict potential vibrations of high-speed trains. In our research, we have tested and developed deep learning model to predict potential vibrations from time series of recorded vibrations during travel. We have tested various training models, different time steps and potential error margins to examine how well we are able to predict situation on the track. Summarizing, in our article we have used the RNN-LSTM neural network model with hyperbolic tangent in hidden layers and rectified linear unit gate at the final layer in order to predict future values from the time series data. Results of our research show the our system is able to predict vibrations with Accuracy of above 99% in series of values forward.
The impact of ambulatory care spending, continuity and processes of care on ambulatory care sensitive hospitalizations
Authors: Schuettig Wiebke , Sundmacher Leonie 
Published: January 2022

AbstractAmbulatory care sensitive hospitalizations are widely considered as important measures of access to as well as quality and performance of primary care. In our study, we investigate the impact of spending, process quality and continuity of care in the ambulatory care sector on ambulatory care sensitive hospitalizations in patients with type 2 diabetes. We used observational data from Germany’s major association of insurance companies from 2012 to 2014 with 55,924 patients, as well as data from additional sources. We conducted negative binomial regression analyses with random effects at the district level. To control for potential endogeneity of spending and physician density in the ambulatory care sector, we used an instrumental variable approach. We controlled for a wide range of covariates, such as age, sex, and comorbidities. The results of our analysis suggest that spending in the ambulatory care sector has weak negative effects on ambulatory care sensitive hospitalizations. We also found that continuity of care was negatively associated with hospital admissions. Patients with type 2 diabetes are at increased risk of hospitalization resulting from ambulatory care sensitive conditions. Our study provides some evidence that increased spending and improved continuity of care while controlling for process quality in the ambulatory care sector may be effective ways to reduce the rate of potentially avoidable hospitalizations among patients with type 2 diabetes.
Haushaltspolitik der neuen Bundesregierung
Authors:   Überblick
Published: January 2022

ZusammenfassungDie neue Bundesregierung aus SPD, Bündnis 90/Die Grünen und FDP hat im Koalitionsvertrag ein „Jahrzehnt der Zukunftsinvestitionen“ in Aussicht gestellt. Bereits im Vorfeld der Koalitionsverhandlungen wurde kontrovers über die finanzpolitischen Möglichkeiten und Spielräume diskutiert. Die Vorhaben der neuen Koalition — Schuldenbremse einhalten, Reform der Grundsicherung, keine Steuererhöhungen, grüne Investitionen — waren dabei häufig als „Quadratur des Kreises“ gesehen worden. Die Autor:innen des Zeitgesprächs diskutieren, ob die im Koalitionsvertrag genannten Finanzierungsinstrumente geeignet sind, um die zentralen finanzpolitischen Herausforderungen in den kommenden Jahren zu bewältigen, und wie die Haushaltspläne mit der Schuldenbremse sowie den fiskalischen Regeln auf EU-Ebene in Einklang gebracht werden können.
Kommunen zentral für Jahrzehnt der Zukunftsinvestitionen
Authors: Rietzler Katja 
Published: January 2022

AbstractIn the coalition agreement, the new federal government holds out the prospect of a “decade of investment for the future”. It thus recognises that considerable additional investment-related government spending is necessary to overcome the investment backlog in Germany and promote the socio-ecological transformation. Based on current studies, a total of 600 to 800 billion euros over ten year seems plausible, with a significant share accruing at the municipal level. The new government addresses important problems of municipal finances including significant regional disparities, but further measures are needed to enable all local communities to invest sufficiently.
Wettbewerb im Deutschlandtakt
Authors: Kühling Jürgen , Greer Katja 
Published: January 2022

ZusammenfassungDie neue Bundesregierung hält an dem verkehrspolitischen Ziel einer Steigerung des Verkehrs auf der Schiene fest. Dazu sieht sie im Koalitionsvertrag neben einer weiteren Erhöhung der Investitionen in die Schieneninfrastruktur auch eine prioritäre Ausrichtung der Finanzierung auf den Deutschlandtakt vor. Damit durch die angestrebte Umgestaltung tatsächlich eine Verkehrsverlagerung auf die Schiene und eine Steigerung des Schienenverkehrs erreicht werden kann, sollte frühzeitig auf eine wettbewerbliche Ausgestaltung geachtet werden. Dafür sind regulatorische Anpassungen notwendig. Ein geeignetes Instrument ist die Umgestaltung des Schienenpersonenfernverkehrs hin zu einem Ausschreibungs- bzw. Konzessionsmodell. Hierdurch könnte die Bedienung der vordefinierten Deutschlandtakt-Strecken sichergestellt werden. Die Umgestaltung kann zudem zu einer Steigerung des Wettbewerbs, einem attraktiveren Bahnmarkt und somit auch zu einer Verkehrssteigerung auf der Schiene beitragen.
Obligatorische Versicherung gegen Schäden infolge von Naturkatastrophen
Authors: Becker Ann-Kristin , Oslislo Christoph 
Published: January 2022

ZusammenfassungWie schon die Hochwasserereignisse 2002 und 2013 haben auch die Folgen der Flutkatastrophe im Juli 2021 dramatisch die Notwendigkeit von gesellschaftlichen Klimaanpassungsstrategien in Deutschland aufgezeigt. Bund und Länder haben zum dritten Mal eine Arbeitsgruppe mit der verfassungsrechtlichen Prüfung einer Versicherungspflicht gegen Elementarschäden beauftragt. Während sich die grundsätzlichen Argumente in der Debatte um die Einführung wiederholen, lohnt sich ein Blick auf die zentralen Ausgestaltungsfragen einer potenziellen Versicherungspflicht. Die häufig vorgebrachten Kritikpunkte gegen eine Versicherungspflicht legen konkrete Ausgestaltungsannahmen zugrunde und sprechen daher nicht pauschal gegen das Instrument.
The concept of disability and its causal mechanisms in older people over time from a theoretical perspective: a literature review
Authors: Mouchaers Ines , Verbeek Hilde , Kempen Gertrudis I. J. M. , van Haastregt Jolanda C. M. , Vlaeyen Ellen , Goderis Geert , Metzelthin Silke F. 
Published: January 2022

AbstractAgeing with a disability increases the risk of hospitalization and nursing home admission. Ageing in place interventions aiming to reduce disability are often not sufficiently effective and inadequately theory-based. There are many models available on disability, but it is unclear how they define disability, what their differences are, and how they evolved throughout the years. This paper aims to provide an overview of the evolution of these models and to elaborate on the causal mechanisms of disability. A literature review was conducted as part of the TRANS-SENIOR international training and research network. PubMed and Google Scholar were searched, and snowball sampling was applied to eligible publications. Data were extracted from the included publications, and a thematic analysis was performed on the retrieved data. Overall, 29 publications were included in the final sample. All included models arose from three original models and could be divided into two types: linear models and models on the interaction between the person and the environment. Thematic analysis led to three distinct evolutionary trends: (1) from a unidirectional linear path to a multidirectional nonlinear path, (2) from the consequences of disease towards the consequences of person–environment interaction, and (3) from disability towards health and functioning. Our findings suggest that by optimizing the use of personal as well as environmental resources, and focusing on health and functioning, rather than disability, an older person’s independence and wellbeing can be improved, especially while performing meaningful daily activities in accordance with the person’s needs and preferences.
Application of the HYSPLIT model for birch pollen modelling in Poland
Authors: Bilińska-Prałat Daria , Werner Małgorzata , Kryza Maciej , Malkiewicz Małgorzata , Rapiejko Piotr , Chłopek Kazimiera , Dąbrowska-Zapart Katarzyna , Lipiec Agnieszka , Jurkiewicz Dariusz , Kalinowska Ewa , Majkowska-Wojciechowska Barbara , Myszkowska Dorota , Piotrowska-Weryszko Krystyna , Puc Małgorzata , Rapiejko Anna , Siergiejko Grzegorz , Weryszko-Chmielewska Elżbieta , Wieczorkiewicz Andrzej , Ziemianin Monika 
Published: January 2022

AbstractIn this work, the HYSPLIT model was used to reproduce birch pollen concentrations in Poland for the years 2015 and 2016, where there was significant variation in terms of pollen concentrations and start/end dates of the pollen season. The analysis of pollen observations showed that the seasonal pollen integral (SPIn) was low in 2015 with a shorter season compared to 2016. In 2016, SPIn was unusually high. The HYSPLIT model simulation, with a one-hour temporal resolution, was conducted during the birch pollen season (from March to May) for 2015 and 2016. Meteorological data were obtained from the WRF model. The birch coverage map of the European Forest Institute was used. The emission, introduced to the model, covered Central Europe with a resolution of 0.3° × 0.3°. The results were compared to data from 11 observation stations in Poland. The measured birch pollen concentrations for 2015 were overestimated by HYSPLIT at 8 of the 11 stations (normalized mean bias/NMB from 0.13 to 2.53) and underestimated for three stations (NMB from − 0.44 to − 0.15). For 2016, the model highly underestimated the pollen concentrations, with NMB ranging from − 0.45 to − 0.93. In general, the results show that the model can resolve the main peaks of pollen concentrations, which is a step forward in the application of the HYSPLIT model for birch pollen forecasting over Poland. We suggest the application of methods that can reduce the bias of temperature such as meteorological data assimilation or bias correction, which could improve calculation of the start of emissions and consequently the start of the pollen season as well as pollen concentrations.
AI-aided general clinical diagnoses verified by third-parties with dynamic uncertain causality graph extended to also include classification
Authors: Zhang Zhan , Jiao Yang , Zhang Mingxia , Wei Bing , Liu Xiao , Zhao Juan , Tian Fengwei , Hu Jie , Zhang Qin 
Published: January 2022

AbstractArtificial intelligence (AI)-aided general clinical diagnosis is helpful to primary clinicians. Machine learning approaches have problems of generalization, interpretability, etc. Dynamic Uncertain Causality Graph (DUCG) based on uncertain casual knowledge provided by clinical experts does not have these problems. This paper extends DUCG to include the representation and inference algorithm for non-causal classification relationships. As a part of general clinical diagnoses, six knowledge bases corresponding to six chief complaints (arthralgia, dyspnea, cough and expectoration, epistaxis, fever with rash and abdominal pain) were constructed through constructing subgraphs relevant to a chief complaint separately and synthesizing them together as the knowledge base of the chief complaint. A subgraph represents variables and causalities related to a single disease that may cause the chief complaint, regardless of which hospital department the disease belongs to. Verified by two groups of third-party hospitals independently, total diagnostic precisions of the six knowledge bases ranged in 96.5–100%, in which the precision for every disease was no less than 80%.
Effects of an oil-based substrate (The Water Cleanser™) and bacterial additives on nitrogen and phosphorous dynamics in freshwater crayfish (Cherax cainii, Austin and Ryan 2002) aquaculture
Authors: Cole Anthony J. , Tulsankar Smita S. , Saunders Benjamin J. , Fotedar Ravi 
Published: January 2022

AbstractTwo experiments were conducted to evaluate the efficacy of an oil-based substrate, The Water Cleanser™ (TWC). The first experiment studied the effects two substrates of different oil composition (TWC, TWC +), and a commercial bacterial additive (Bio-Aid) on concentrations of nitrogen and phosphorous in indoor aquaria. The second experiment studied the effects of TWC, a bacterial additive, and a combination (TWC + B) on concentrations of nitrogen and phosphorous, phytoplankton abundance and diversity in outdoor freshwater crayfish (Cherax cainii, Austin and Ryan, Invertebr Syst 16:357–367, 2002) tanks. In the first experiment, the concentration of TAN decreased more rapidly with Bio-Aid, whilst the maximum concentrations of NO2-N and NO3-N were reduced with the substrates. The concentration of orthophosphate was reduced in aquaria with TWC + . In the second experiment, concentrations of TAN, NO2-N, NO3-N and total phosphate were not significantly affected by TWC. After addition of TWC + B, there was a significant decrease in the concentrations of nitrate and total phosphate, and a higher abundance of phytoplankton was maintained than with other treatments. Additionally, a population Bacillus sp. was found on the substrate surface. TWC had no adverse effects on phytoplankton abundance or diversity, or C. cainii physiology, weight gain or survival. TWC and TWC + were effective bioremediators of eutrophic water, whilst a combination of TWC + B was effective in short term bioremediation and in promoting phytoplankton abundance in C. cainii tank culture.