bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Role of SUMO and SUMOylation in the Pathogenesis of
Diabetes Mellitus
Authors: Sadeghi Mahvash , Dehnavi Sajad , Shohan Mojtaba , Jamialahmadi Tannaz , Sathyapalan Thozhukat , Sahebkar Amirhossein 
Published: August 2022

Abstract:
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and associated with multiple organ systems complications. The incidence and prevalence of diabetes are increasing in an epidemic proportion worldwide. In addition to environmental factors, some epigenetic and post-translational modifications have critical roles in the pathogenesis of diabetes and its complications. Reversible covalent modification such as SUMOylation by SUMO (Small Ubiquitin-like Modifier) has emerged as a new mechanism that affects the dynamic regulation of proteins. In this review, we initially focus on the function of SUMO and SUMOylation. Subsequently, we assess the potential effects of this process in the pathogenesis of type 1 and 2 diabetes mellitus.
Hymenoptera Venom Allergy and Anaphylaxis
Authors: Bilò Maria Beatrice , Martini Matteo , Danieli Maria Giovanna , Moroncini Gianluca 
Published: August 2022

Abstract:
Hymenoptera stings can induce allergic and occasionally fatal reactions, and are responsible for significant
morbidity and deterioration in health-related quality of life. The diagnostic work-up must consider the
medical history of patients, in the context of venom allergy epidemiology and Hymenoptera taxonomy, and the
clinical manifestations of the reactions, to channel the available in vivo and in vitro tests towards the most accurate
diagnosis and the consequent appropriate management, also considering the risk profile of the patients on a
precision-medicine approach. All these aspects are covered by this work that aims at providing an up-to-date
review to increase the awareness of this topic among interested stakeholders, like healthcare professionals and
political decision makers, who can contribute to the proper immediate and long-term management of venom
allergy and anaphylaxis.
A Sciatic Neuralgia Case of an Entrapment Neuropathy Mimicking
Piriformis Syndrome Due to Soft Tissue Hemangioma
Authors: Arik Şeref Barbaros , Günaydin Elif 
Published: August 2022

Background:
Lumbosacral pain is commonly seen in daily clinical practice. In fact, entrapment of the part of the sciatic nerve after the sacral foramen causes some of these pains, which should not be overlooked. The sciatic nerve may be compressed during its course after the sacral foramen for a variety of reasons. We aimed in this article to review extra-spinal compressive sciatic neuropathy reasons and abnormal magnetic resonance imaging (MRI) by presenting a sciatic neuralgia case of an entrapment neuropathy mimicking piriformis syndrome due to soft tissue hemangioma.

Case Presentation:
A 30-year-old male patient was admitted with complaints of lumbosacral pain
spreading to the leg that had been worsening over the previous 10 days. With the preliminary diagnosis
of labral damage and piriformis syndrome, the patient was referred to the radiology clinic for a hip
MRI. In the hip MR images, a mass lesion suggestive of heterogeneously enhanced soft tissue hemangioma
after the injection of paramagnetic contrast material was observed in the proximal left thigh.
The soft tissue hemangioma extends towards the obturator foramen and compresses the sciatic nerve
proximal to the femur after the sciatic foramen.

Conclusion:
The diagnosis of lower extremity entrapment neuropathy is frequently misdiagnosed. In these cases, MRI becomes more important for accurate diagnosis The radiologists' knowledge of the sciatic nerve in MRI, regional anatomy during the course of the sciatic nerve, and abnormal nerve imaging findings will aid in the diagnosis.
Influence of Morphology Change on Photoelectrochemical Activity of
Cerium Oxide Nanostructures
Authors: Padalkar Sonal , Fallatah Ahmad , Kuku Mohammed , De Penning Rebekah , Almomtan Mohammed 
Published: August 2022

Aims:
Photocatalysis has become a crucial area in the field of energy generation

Background:
The conversion of solar energy into chemical or thermal energy for various energy related applications has taken precedence over many traditional research areas. Objective: The urgency to become independent of non-renewable energy resources is paramount due to issues of global warming.

Objective:
The urgency to become independent of non-renewable energy resources is paramount due to issues of global warming.

Method:
To that end, researchers are exploring various material systems, geometries and material combinations to obtain ideal photocatalysts for efficient solar conversion. Here, the nanostructures were fabricated via electrodeposition.

Results and Discussion:
The morphology was controlled by varying the concentration of chemical additive, namely dimethyl sulfoxide, during the deposition process. The morphology controlled cerium oxide nanostructures were thoroughly characterized and tested for their photoelectrochemical performances.

Conclusion:
Our present investigation contributes to this area of research by studying the influence of morphology on the photoelectrochemical activity of cerium oxide nanostructures.
Protein-Based Drug Delivery Nanomedicine Platforms: Recent Developments
Authors: Aljabali Alaa A.A. , Rezigue Meriem , Alsharedeh Rawan H. , Obeid Mohammad A. , Mishra Vijay , Serrano-Aroca Ángel , Tambuwala Murtaza M. 
Published: August 2022

Background:
Naturally occurring protein cages, both viral and non-viral assemblies,
have been developed for various pharmaceutical applications. Protein cages are ideal platforms as
they are compatible, biodegradable, bioavailable, and amenable to chemical and genetic modification
to impart new functionalities for selective targeting or tracking of proteins. The ferritin/
apoferritin protein cage, plant-derived viral capsids, the small Heat shock protein, albumin,
soy and whey protein, collagen, and gelatin have all been exploited and characterized as drugdelivery
vehicles. Protein cages come in many shapes and types with unique features such as
unmatched uniformity, size, and conjugations.

Objectives:
The recent strategic development of drug delivery will be covered in this review,
emphasizing polymer-based, specifically protein-based, drug delivery nanomedicine platforms.
The potential and drawbacks of each kind of protein-based drug-delivery system will also be
highlighted.

Methods:
Research examining the usability of nanomaterials in the pharmaceutical and medical
sectors were identified by employing bibliographic databases and web search engines.

Results:
Rings, tubes, and cages are unique protein structures that occur in the biological environment
and might serve as building blocks for nanomachines. Furthermore, numerous virions
can undergo reversible structural conformational changes that open or close gated pores, allowing
customizable accessibility to their core and ideal delivery vehicles.

Conclusion:
Protein cages' biocompatibility and their ability to be precisely engineered indicate
they have significant potential in drug delivery and intracellular administration.
SEDDS Basic Design and Recent Formulation Advancement: A Concurrent
Review
Authors: Panigrahi K.C. , Patra C.N. , Rao M.E.B. , Jena G.K. , Sahoo L. 
Published: August 2022

Abstract:
In the present scenario, lipid-based novel drug delivery systems are the area of interest for
the formulation scientist in order to improve the bioavailability of poorly water-soluble drugs. A selfemulsifying
drug delivery system (SEDDS) upon contact with the gastrointestinal fluid, forms an o/w
emulsion. SEDDS has gained popularity as a potential platform for improving the bioavailability of
the lipophilic drug by overcoming several challenges. The various advantages like improved solubility,
bypassing lymphatic transport, and improvement in bioavailability are associated with SMEDDS or
SNEDDS. The extent of the formation of stable SEDDS depends on a specific combination of surfactant,
co-surfactant, and oil. The present review highlighted the different aspects of formulation design
along with optimization and characterization of SEDDS formulation. It also gives a brief description
of the various aspects of the excipients used in SEDDS formulation. This review also includes the
conflict between types of SEDDS based on droplet size. There is an extensive review of various research
regarding different solidification techniques used for SEDDS in the last three years.
A Comprehensive Review on the Medicinal Benefits of Honey with an Emphasis
on Unani Medicine
Authors: Husain Nazim , Khalid Mohd , Rahmatullah Md , Alam Abrar , Beg Mohd Uzair 
Published: August 2022

Background:
Honey has been used medicinally in folk medicine since the dawn of civilization. It is a necessary component of medicine and food in a wide variety of cultures. It has been used in Unani Medicine for centuries to treat a variety of ailments.

Objective:
This review article aims to explore the medicinal characteristics of honey in view of Unani and modern concepts; to highlight its potential in the treatment of the ailments stated in Unani medical literature; and also to explore the relevant evidence-based phytochemistry, pharmacological, and clinical data.

Methods:
The authors searched classical texts exhaustively for information on the temperament (Mizāj), pharmacological activities, mechanism of action, and therapeutic benefits of honey. Additionally, a comprehensive search of internet databases was conducted to compile all available information on the physicochemical, phytochemical, and pharmacological properties of this compound.

Results:
Evidence suggests that honey contains about 180 different types of various compounds including carbohydrates, proteins, enzymes, flavonoids, and other chemical substances. In Unani classical literature, it exerts important pharmacological actions besides its immense nutritional significance. Unani physicians advocated many tested/experimented prescriptions and formulations, which still have their relevance in the amelioration of various diseases.

Conclusion:
This analysis concludes that honey has been successfully utilized in Unani medicine for centuries to treat a variety of maladies and is a potential natural source of remedy for a variety of medical disorders. Future research on honey should include a combination of Unani and modern principles.
Research on Electromagnetic Suspension Characteristics of 12-slot 6-Pole
Single-winding BL-BLDCM
Authors: Bu Wenshao , Zhang Fei 
Published: August 2022

Background:
The independent suspension winding in the dual-winding bearingless motor
reduces the power density of the motor, and the amplitude of radial magnetic suspension force
is affected by the limited slot space. As for the single-winding bearingless brushless direct current
motor (BL-BLDCM), although preliminary researches have been carried out, a detailed analysis of
its electromagnetic suspension characteristics is lacking.

Objective:
The magnetic suspension force mathematical model and electromagnetic suspension
characteristics are analyzed through a single winding BL-BLDCM with a 12-slot/tooth stator and a
6-pole permanent magnet (PM) rotor.

Method:
First, the structure and working principle of the motor are introduced, and the mathematical
model of the magnetic suspension is derived. Then, through Maxwell software, a twodimensional
finite element model of the single-winding BL-BLDCM is established. Finally, the
variation of the controllable magnetic suspension force and the coupling radial force along the vertical
axis with the key structural parameters such as the air gap length, the PM pole arc coefficient,
and the PM thickness are studied.

Results:
The law of radial controllable magnetic suspension force and the coupling radial force
along the vertical axis changing with related parameters is given, and the analytical model of radial
magnetic suspension force is verified.

Conclusion:
The proposed radial suspension force mathematical model is effective; the analysis
results of electromagnetic suspension characteristics can provide a reference for the optimal design
of single winding BL-BLDCM.
Pesquisa-Formação em Etnocomunicação no Contexto Contemporâneo
Authors: Zenha Leonardo 
Published: August 2022

O artigo em questão faz parte de pesquisa de Pós-Doutorado em diálogo com parceiras do Projeto omitido segundo as normas da revista A proposta resulta de experiências de ensino, pesquisa, extensão e atuação na pós-graduação, tendo como método a pesquisa-formação multirreferencial (SANTOS, 2019; ARDOINO,1998) no campo da educação e comunicação com os povos indígenas do Brasil. Objetiva discutir questões envolvendo a etnocomunicação como dispositivo de luta identitária, ancestral e decolonial, e os diferentes usos das Tecnologias Digitais de Informação e Comunicação (TDICs). A metodologia utilizada é a pesquisa-formação com imersão nos movimentos assumidos pelos povos originários, no movimento nacional de luta por direitos constitucionais e da terra, e com ações articuladas ao projeto de formação de professores indígenas ASIE. Pistas iniciais nos levam a compreender que as tecnologias digitais contemporâneas são apropriadas para comunicação, mas ainda pouco inseridas nas práticas educativas no contexto investigado.
Apprentices’ Attitudes Toward Using a Mental Health Mobile App to Support Healthy Coping: Mixed Methods Study
Authors: Choi Isabella , Petrie Katherine , Einboden Rochelle , Collins Daniel , Ryan Rose , Johnston David , Harvey Samuel B , Glozier Nicholas , Wray Alexis , Deady Mark 
Published: August 2022

Background
Apprenticeships are a common pathway for young people transitioning into the workforce. Apprentices often face many employment-related challenges and have high levels of psychological distress, drug and alcohol use, and suicidal ideation. Little is known about the attitudes of apprentices toward using smartphone apps to support their mental health and the content that would engage them.

Objective
This study explored (1) apprentices’ interest in using an app to support their mental health and (2) the healthy coping strategies used to manage their mental well-being in the face of workplace challenges, in order to inform future app content.

Methods
A mixed methods study was conducted with 54 apprentices (50/54 male, 93%) with a mean age of 22.7 (SD 5.7) years. Participants completed a survey on preferred ways of using an app to support mental health. Across 8 focus groups, participants were asked to describe healthy strategies they used to cope with occupational stressors.

Results
Only 11% (6/54) of participants currently used a well-being app, but there was high interest in using an app to support their friends (47/54 participants, 87%) and develop self-help strategies to manage or prevent mental health issues (42/54 participants, 78%). Four major types of coping behaviors were identified: (1) social connection for disclosure, advice, and socializing; (2) pleasurable activities, such as engaging in hobbies, time-outs, and developing work-life separation; (3) cognitive approaches, including defusing from thoughts and cognitive reframing; and (4) self-care approaches, including exercise, a healthy diet, and getting adequate sleep.

Conclusions
There is interest among apprentices to use an app with a positive well-being focus that helps them to develop self-management skills and support their friends. Apprentices utilized a range of healthy behaviors to cope with workplace stressors that can be incorporated into mental health apps to improve uptake and engagement. However, many of the preferred coping strategies identified are not those focused on by currently available apps, indicating the need for more targeted digital interventions for this group.
Efficacy of Virtual Care for Depressive Disorders: Systematic Review and Meta-analysis
Authors: Schiller Crystal Edler , Prim Julianna , Bauer Anna E , Lux Linda , Lundegard Laura Claire , Kang Michelle , Hellberg Samantha , Thompson Katherine , Webber Theresa , Teklezghi Adonay , Pettee Noah , Gaffney Katherine , Hodgins Gabrielle , Rahman Fariha , Steinsiek J Nikki , Modi Anita , Gaynes Bradley N 
Published: August 2022

Background
The COVID-19 pandemic has created an epidemic of distress-related mental disorders such as depression, while simultaneously necessitating a shift to virtual domains of mental health care; yet, the evidence to support the use of virtual interventions is unclear.

Objective
The purpose of this study was to evaluate the efficacy of virtual interventions for depressive disorders by addressing three key questions: (1) Does virtual intervention provide better outcomes than no treatment or other control conditions (ie, waitlist, treatment as usual [TAU], or attention control)? (2) Does in-person intervention provide better outcomes than virtual intervention? (3) Does one type of virtual intervention provide better outcomes than another?

Methods
We searched the PubMed, EMBASE, and PsycINFO databases for trials published from January 1, 2010, to October 30, 2021. We included randomized controlled trials of adults with depressive disorders that tested a virtual intervention and used a validated depression measure. Primary outcomes were defined as remission (ie, no longer meeting the clinical cutoff for depression), response (ie, a clinically significant reduction in depressive symptoms), and depression severity at posttreatment. Two researchers independently selected studies and extracted data using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Risk of bias was evaluated based on Agency for Healthcare and Research Quality guidelines. We calculated odds ratios (ORs) for binary outcomes and standardized mean differences (SMDs) for continuous outcomes.

Results
We identified 3797 references, 24 of which were eligible. Compared with waitlist, virtual intervention had higher odds of remission (OR 10.30, 95% CI 5.70-18.60; N=619 patients) and lower posttreatment symptom severity (SMD 0.81, 95% CI 0.52-1.10; N=1071). Compared with TAU and virtual attention control conditions, virtual intervention had higher odds of remission (OR 2.27, 95% CI 1.10-3.35; N=512) and lower posttreatment symptom severity (SMD 0.25, 95% CI 0.09-0.42; N=573). In-person intervention outcomes were not significantly different from virtual intervention outcomes (eg, remission OR 0.84, CI 0.51-1.37; N=789). No eligible studies directly compared one active virtual intervention to another.

Conclusions
Virtual interventions were efficacious compared with control conditions, including waitlist control, TAU, and attention control. Although the number of studies was relatively small, the strength of evidence was moderate that in-person interventions did not yield significantly better outcomes than virtual interventions for depressive disorders.
Resilience in Web-Based Mental Health Communities: Building a Resilience Dictionary With Semiautomatic Text Analysis
Authors: Kang Yong-Bin , McCosker Anthony , Kamstra Peter , Farmer Jane 
Published: August 2022

Background
Resilience is an accepted strengths-based concept that responds to change, adversity, and crises. This concept underpins both personal and community-based preventive approaches to mental health issues and shapes digital interventions. Online mental health peer-support forums have played a prominent role in enhancing resilience by providing accessible places for sharing lived experiences of mental issues and finding support. However, little research has been conducted on whether and how resilience is realized, hindering service providers’ ability to optimize resilience outcomes.

Objective
This study aimed to create a resilience dictionary that reflects the characteristics and realization of resilience within online mental health peer-support forums. The findings can be used to guide further analysis and improve resilience outcomes in mental health forums through targeted moderation and management.

Methods
A semiautomatic approach to creating a resilience dictionary was proposed using topic modeling and qualitative content analysis. We present a systematic 4-phase analysis pipeline that preprocesses raw forum posts, discovers core themes, conceptualizes resilience indicators, and generates a resilience dictionary. Our approach was applied to a mental health forum run by SANE (Schizophrenia: A National Emergency) Australia, with 70,179 forum posts between 2018 and 2020 by 2357 users being analyzed.

Results
The resilience dictionary and taxonomy developed in this study, reveal how resilience indicators (ie, “social capital,” “belonging,” “learning,” “adaptive capacity,” and “self-efficacy”) are characterized by themes commonly discussed in the forums; each theme’s top 10 most relevant descriptive terms and their synonyms; and the relatedness of resilience, reflecting a taxonomy of indicators that are more comprehensive (or compound) and more likely to facilitate the realization of others. The study showed that the resilience indicators “learning,” “belonging,” and “social capital” were more commonly realized, and “belonging” and “learning” served as foundations for “social capital” and “adaptive capacity” across the 2-year study period.

Conclusions
This study presents a resilience dictionary that improves our understanding of how aspects of resilience are realized in web-based mental health forums. The dictionary provides novel guidance on how to improve training to support and enhance automated systems for moderating mental health forum discussions.
THE EFFECT OF ORGANIZATIONAL CLIMATE AND COMPENSATION ON JOB SATISFACTION OF ADMINISTRATIVE EMPLOYEES UIN AR-RANIRY BANDA ACEH
Authors: Yulindawati Yulindawati 
Published: August 2022

The purpose of this study was to determine the compensation of the organizational climate and job satisfaction partially or simultaneously to the administration of employee performance UIN Ar-Raniry Banda Aceh. The population in this study was done by using Proportional Stratified Random Sampling by the number of employees 162 people made in the research sample. The analysis methods used were data instrument tests which are data validity as well .The results showed a positive relationship between organizational climate variables and compensation effect on job satisfaction UIN Ar-Raniry Administration Banda Aceh.
KAJIAN YURIDIS SUMBER-SUMBER HUKUM
Authors: Abdullah Arifin 
Published: August 2022

Dalam karya ilmiah ini sedikit menbahas tentang sumber hukum dalam arti formil dan dalam arti matril, kemudian dilanjutkan dengan penafsiran hukum dan macam, macam penafsiran hukum, artikel ini masih jauh sekali dari sempurna, karena keterbatasan pemakalah, namun dari itu saya sadari bahwa demi kesempurnaan makalah ini mohon krikan dan saran dai teman-teman semua, terkhusu kepada dosem pengasuk Mata kuliah ini. Dilihat secara normatif yuridis, melihat aturan-aturan dan pendapat ahli tentang sumber-sumber hukum
PERANCANGAN GAME EDUKASI MATERI SISTEM TATA SURYA
Authors: Belanof Derio 
Published: August 2022

Tujuan penelitian ini untuk mengetahui hasil perancangan aplikasi game edukasi materi sistem tata surya. Dalam penelitian ini metode yang digunakan adalah research and development (R&D) dengan menggunakan model pengembangan luther yang terdiri dari enam tahapan yaitu: konsep, perancangan pengumpulan bahan, pembuatan, pengujian dan distribusi. Game tersebut divalidasi oleh dua ahli yaitu ahli media dan juga ahli materi untuk mengetahui kelayakannya dan kemudian diuji coba kepada siswa. Penelitian ini dilakukan di smp 4 banda aceh dengan melibatkan 18 siswa. Metode pengambilan data menggunakan angket dan data tersebut di analisis secara deskriptif untuk mengetahui kelayakannya. Penelitian ini menghasilkan kelayakan dari ahli media dengan nilai persentase 84,6%, dari ahli materi dengan nilai persentase 90%, dan dari hasil uji coba dari siswa diperoleh dengan nilai persentase 86,6% Maka dari perolehan di atas maka aplikasi ini layak digunakan sebagai media pembelajaran.