bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beetles on the move: Not‐just‐a‐technical review of beetles' radio‐tracking
Authors: Růžičková Jana , Elek Zoltán 
Published: December 2022

AbstractRadio telemetry with very high‐frequency transmitters is a powerful tool for studying the movement patterns of animals. Although this tracking technology is widely utilized for various vertebrates, its application is limited to only a fraction of large‐bodied insect species. Among them, beetles are the most popular insect group used for radio‐tracking due to their relatively large body size, solid exoskeleton, and to some extent the well‐known ecological background of some species. Here, we review the available literature about radio telemetry applied to beetles, focusing on current methodological advantages and constraints to record their movement, as well as how this method can assist in understanding various ecological aspects of beetle life history. Regardless of the huge potential of radio‐tracking, the number of tracked beetle species is still very low, covering so far only 13 species belonging to five families that were studied almost exclusively in the Western Palearctic region. Most studies were descriptive, measuring simple trajectory parameters and examining movement behavior as a single strategy that is not triggered by any particular internal or external cues. Ecological aspects have been accessed to a lesser extent, especially in relation to the effects of abiotic factors and habitat use. There are still conceptual knowledge gaps: promising statistical approaches for movement analyses can connect movement patterns with specific habitat utilization but they are not yet used by entomologists. Moreover, knowing the movement patterns of many individuals and species can assist us to understand the composition and dynamics at the community level.
Job shadowing for early undergraduate dental students: Evaluation and validation of educational effectiveness using structural equation modelling
Authors: Abe Susumu , Matsuka Yoshizo , Murakami Ayu , Rodis Omar Marianito Maningo , Oka Kenji , Okawa Toshinori , Wada‐Mihara Chie , Shinohara Chihiro , Kawano Fumiaki 
Published: December 2022

AbstractIntroductionThis study aimed to evaluate and validate the educational effectiveness of a job shadowing class as a dental teaching programme for preclinical dental students through a questionnaire that assessed related student perceptions.Materials and MethodsA total of 124 preclinical (second year) dental students at Tokushima University participated in job shadowing placements from 2017 to 2019. Each student observed dental practice or surgery for 1 day in the university hospital. After shadowing, the students were requested to fill out a nine‐item questionnaire based on a five‐point scale. The first analysis was performed to calculate the correlation for each item. Furthermore, regression analysis for the categorical data was performed to show the relationship between eight questions (Items 1–8) and one question (Item 9: comprehensive evaluation). Next, factor analysis was performed to determine students' perceptions regarding the shadowing class.ResultsNinety‐eight students (response rate: 79%) completed the questionnaire. There was a strong relationship amongst Items 1, 8 and 9 (“interested in dentistry as a job,” “learning motivation” and “comprehensive evaluation” respectively) based on the results of the correlation and regression analysis. The factor analysis led to three student perceptions as latent factors, namely, “Interesting,” “Self‐awareness” and “Future Goal,” which had a relatively close inter‐factor correlation (0.465–0.772).ConclusionThe finding suggests that job shadowing may increase a students' interest in a dentistry career at an early stage of their education and learning motivation, along with generating self‐awareness. This programme may present possible educational effectiveness in dental education.
Characterizing SOD1 mutations in Spain: The impact of genotype, age and sex in the natural history of the disease
Authors: Vázquez‐Costa Juan F. , Borrego‐Hernández Daniel , Paradas Carmen , Gómez‐Caravaca María Teresa , Rojas‐Garcia Ricardo , Varona Luis , Povedano Mónica , García‐Sobrino Tania , Jericó Pascual Ivonne , Gutiérrez Antonio , Riancho Javier , Turon‐Sans Janina , Assialioui Abdelilah , Pérez‐Tur Jordi , Sevilla Teresa , Esteban Pérez Jesús , García‐Redondo Alberto ,   ALSGESCO
Published: December 2022

AbstractBackground and purposeThe aim of this study was to describe the frequency and distribution of SOD1 mutations in Spain, and to explore factors contributing to their phenotype and prognosis.MethodsSeventeen centres shared data on amyotrophic lateral sclerosis (ALS) patients carrying pathogenic or likely pathogenic SOD1 variants. Multivariable models were used to explore prognostic modifiers.ResultsIn 144 patients (from 88 families), 29 mutations (26 missense, 2 deletion/insertion and 1 frameshift) were found in all five exons of SOD1, including seven novel mutations. A total of 2.6% of ALS patients (including 17.7% familial and 1.3% sporadic) were estimated to carry SOD1 mutations. The frequency of this mutation varied considerably among regions, due to founder events. The most frequent mutation was p.Gly38Arg (n = 58), followed by p.Glu22Gly (n = 11), p.Asn140His (n = 10), and the novel p.Leu120Val (n = 10). Most mutations were characterized by a protracted course, and some of them by atypical phenotypes. Older age of onset was independently associated with faster disease progression (exp[Estimate] = 1.03 [0.01, 0.05], p = 0.001) and poorer survival (hazard ratio 1.05 [1.01, 1.08], p = 0.007), regardless of the underlying mutation. Female sex was independently associated with faster disease progression (exp[Estimate] = 2.1 [1.23, 3.65], p = 0.012) in patients carrying the p.Gly38Arg mutation, resulting in shorter survival compared with male carriers (236 vs. 301 months).ConclusionsThese data may help to evaluate the efficacy of SOD1 targeted treatments, and to expand the number of patients that might benefit from these treatments.
Research transparency in dental research: A programmatic analysis
Authors: Raittio Eero , Sofi‐Mahmudi Ahmad , Uribe Sergio E. 
Published: December 2022

AbstractWe assessed adherence to five transparency practices—data sharing, code sharing, conflict of interest disclosure, funding disclosure, and protocol registration—in articles in dental journals. We searched and exported the full text of all research articles from PubMed‐indexed dental journals available in the Europe PubMed Central database until the end of 2021. We programmatically assessed their adherence to the five transparency practices using a validated and automated tool. Journal‐ and article‐related information was retrieved from ScimagoJR and Journal Citation Reports. Of all 329,784 articles published in PubMed‐indexed dental journals, 10,659 (3.2%) were available to download. Of those, 77% included a conflict of interest disclosure, and 62% included a funding disclosure. Seven percent of the articles had a registered protocol. Data sharing (2.0%) and code sharing (0.1%) were rarer. Sixteen percent of articles did not adhere to any of the five transparency practices, 29% adhered to one, 48% adhered to two, 7.0% adhered to three, 0.3% adhered to four, and no article adhered to all five practices. Adherence to transparency practices increased over time; however, data and code sharing especially remained rare. Coordinated efforts involving all stakeholders are needed to change current transparency practices in dental research.
Daily resting‐state intracranial EEG connectivity for seizure risk forecasts
Authors: Cousyn Louis , Messaoud Rémy Ben , Lehongre Katia , Frazzini Valerio , Lambrecq Virginie , Adam Claude , Mathon Bertrand , Navarro Vincent , Chavez Mario 
Published: December 2022

AbstractForecasting seizure risk aims to detect proictal states in which seizures would be more likely to occur. Classical seizure prediction models are trained over long‐term electroencephalographic (EEG) recordings to detect specific preictal changes for each seizure, independently of those induced by shifts in states of vigilance. A daily single measure—during a vigilance‐controlled period—to estimate the risk of upcoming seizure(s) would be more convenient. Here, we evaluated whether intracranial EEG connectivity (phase‐locking value), estimated from daily vigilance‐controlled resting‐state recordings, could allow distinguishing interictal (no seizure) from preictal (seizure within the next 24 h) states. We also assessed its relevance for daily forecasts of seizure risk using machine learning models. Connectivity in the theta band was found to provide the best prediction performances (area under the curve ≥ .7 in 80% of patients), with accurate daily and prospective probabilistic forecasts (mean Brier score and Brier skill score of .13 and .72, respectively). More efficient ambulatory clinical application could be considered using mobile EEG or chronic implanted devices.
Latent class analysis of eHealth behaviors among adults with epilepsy
Authors: Kee Dustin , Jetté Nathalie , Blank Leah J. , Kummer Benjamin R. , Mazumdar Madhu , Agarwal Parul 
Published: December 2022

AbstractObjectiveThe objective of this study was to determine the proportions of uptake and factors associated with electronic health (eHealth) behaviors among adults with epilepsy.MethodsThe 2013, 2015, and 2017 National Health Interview Surveys were analyzed. We assessed the proportions of use of five domains of eHealth in those with epilepsy: looked up health information on the internet, filled a prescription on the internet, scheduled a medical appointment on the internet, communicated with a health care provider via email, and used chat groups to learn about health topics. Multivariate logistic regressions were conducted to identify factors associated with any eHealth behaviors among those with active epilepsy. Latent class analysis was performed to identify underlying patterns of eHealth activity. Survey participants were classified into three discrete classes: (1) frequent, (2) infrequent, and (3) nonusers of eHealth. Multinomial logistic regression was performed to identify factors associated with frequency of eHealth use.ResultsThere were 1770 adults with epilepsy, of whom 65.87% had at least one eHealth behavior in the prior year. By domain, 62.61% looked up health information on the internet, 15.81% filled a prescription on the internet, 14.95% scheduled a medical appointment on the internet, 17.20% communicated with a health care provider via email, and 8.27% used chat groups to learn about health topics. Among those with active epilepsy, female sex, more frequent computer usage, and internet usage were associated with any eHealth behavior. Female sex and frequent computer use were associated with frequent eHealth use as compared to nonusers.SignificanceA majority of persons with epilepsy were found to use at least one form of eHealth. Various technological and demographic factors were associated with eHealth behaviors. Individuals with lower eHealth behaviors should be provided with targeted interventions that address barriers to the adoption of these technologies.
Pharmacokinetics of single dose administration of three increasing doses of acetaminophen per os in 1–3‐month‐old foals
Authors: Gold Jenifer Robin , Grubb Tamara , Court Michael , Villarino Nicolas Francisco 
Published: December 2022

AbstractBackgroundAcetaminophen is a common analgesic and antipyretic drug used in human medicine and might be an alternative to nonsteroidal anti‐inflammatory drugs for treating pain and pyrexia in foals. The pharmacokinetics and safety of differing doses of acetaminophen have not been investigated in foals.ObjectivesTo determine the plasma pharmacokinetics and any changes in haematology and biochemistry profiles following oral administration of single doses of acetaminophen at 10, 20, and 40 mg/kg to foals.Study designRandomised cross‐over pharmacokinetic study.MethodsSix Quarter Horse (two colts and four fillies) foals received 10, 20, and 40 mg/kg acetaminophen orally once. Haematology and biochemistry profiles were performed before and 7 days after each drug administration. Blood samples were collected over 64 h after drug administration and were used to quantify plasma acetaminophen concentrations by liquid chromatography. Pharmacokinetic parameters were determined using compartmental analysis.ResultsMedian (range) acetaminophen plasma concentrations were 4.4 (1.8–5.1), 6.3 (2.6–12.6), and 14 (7.3–18) μg/ml for the 10, 20, and 40 mg/kg doses, respectively. Median acetaminophen area under the concentration versus time curve (AUC)0–∞ranged from 25 (11–32), 41 (22–74), and 105 (82–142) h × μg/ml for the 10, 20, and 40 mg/kg doses, respectively. Dose‐normalised maximal concentrations and AUC0–∞values were similar across dose concentrations (p > 0.05). Median terminal half‐life for all doses was 2.7–2.8 h. Haematology and biochemistry profiles were normal except for blood urea nitrogen and alkaline phosphatase concentrations.Main limitationsFoals were growing throughout the study, starting at 1 month and ending at 3 months. Deposition of drugs changes with age. The sample size was small and only single doses were evaluated. No liver biopsies were performed.ConclusionPlasma disposition of acetaminophen after a single oral dose of 10, 20, and 40 mg/kg to 1–3‐month‐old foals varies greatly with the dose. The analgesic and antipyretic effect in foals is unknown.
Robot facilitated rehabilitation of children with autism spectrum disorder: A 10 year scoping review
Authors: Kohli Manu , Kar Arpan Kumar , Sinha Shuchi 
Published: December 2022

AbstractBackgroundA severe shortage of skilled clinicians and infrastructure limits the delivery of early intervention programmes for autism spectrum disorder (ASD) children that are labour and duration intensive and most advantageous in the first 3 years.AimAssess the role of robot mediated intervention (RMI) role in the rehabilitation of ASD individuals by responding to five research questions in the area of (1) Technology maturity; (2) Skill improvement areas; (3) Research design including participant's demographics, datasets, intervention details, and evaluation tools; (4) Data gathering, analysis, and technology contribution, and (5) Role of Robots in intervention and its effectiveness.MethodsScoping review included RMI studies for ASD individuals published in PUBMED, SCOPUS, and IEEE‐Xplore databases between January 1, 2011, and December 31, 2020. The publications were evaluated utilizing the PRISMA scoping review criteria (PRISMA‐ScR) checklist and the Critical Appraisal Skills Program (CASP).ResultsThe 59 selected publications demonstrated that RMI improved skills for ASD individuals in 12 areas. During RMI, extensive joint attention stimuli were given to ASD individuals, and the therapy promoted ASD children's eye contact, imitation, socio‐communication, and academic skills. However, various ethical, privacy, and safety concerns were reported in the review.ConclusionRMI can improve access, quality, and affordability in ASD intervention. The acceptance and use of technology can be fast‐tracked by (1) incorporating statistically valid study designs; (2) carrying out field trials including diverse participant groups; (3) standardizing datasets with quality parameters; (4) recruiting statistically appropriate participant groups from ASD, Neuro Typical (NT) and diverse developmental disorder population; and (5) and addressing ethical, privacy, safety, trust, and other stakeholder concerns.
Parental COVID‐19–related health information practises, sources, evaluations and needs: A qualitative interview study
Authors: Altawil Hala , Klawunn Ronny , Dierks Marie‐Luise , Lander Jonas 
Published: December 2022

AbstractBackgroundParents of infants and young children may have specific health information needs and preferences, as they are responsible for their children's health. COVID‐19 posed many challenges for families, not least in terms of the constantly updated disease‐prevention guidelines. However, little is known about parents' experiences with this unprecedented situation, that is, how and where they seek, use and evaluate COVID‐19 (child)‐specific health information. We aimed to find out more about this to provide insights to health (information) providers when communicating pandemic information to parents.MethodsWe conducted semistructured telephone interviews (August to October 2020) with a purposively selected sample of 20 German‐speaking and 10 Arabic‐speaking parents of children up to 4 years old. Recruitment occurred through multiple channels, including childcare institutions and social media. Qualitative content analysis of the interview transcripts illustrates the main differences between the two groups.ResultsBy the time the interviews were conducted (mid‐2020), some parents reported to seek information less actively or not at all, compared to the beginning of COVID‐19. German speakers frequently used Google to obtain information, whereas Arabic speakers mentioned social media (particularly Facebook) as a central source. However, medical providers were the most trusted source for child health. Though determining the credibility of online information was difficult for some parents, others, mostly German speakers (middle–high education), were aware of some author‐related criteria. When deciding on information use, parents often rely on their own judgement and gut instinct. Besides the necessity to disseminate information via multiple outlets to reach all parents, Arabic speakers desired audio‐visual and translation tools to facilitate understanding.Discussion and Public ConclusionApart from education, language and knowledge of the health system and of the attributes of credible information may determine its quality and consequent decisions. There seems to be a considerable need to foster knowledge about reliable information sources, a greater understanding of the range of quality criteria and specific support for nonnative speakers, not least to better inform parents' decision‐making.Patient and Public ContributionA parent panel (n = 7) contributed to gathering ideas regarding recruitment, discussing initial results and the choice of topics and questions for a second interview phase.
Real‐world outcomes of pembrolizumab for platinum‐refractory advanced urothelial carcinoma: Efficacy, safety, and evidence for trial‐unfit patients
Authors: Ito Katsuhiro , Kita Yuki , Kobayashi Takashi 
Published: December 2022

AbstractPembrolizumab, monoclonal antibody targeting programmed cell death 1, is widely used for platinum‐refractory urothelial carcinoma (UC) patients. Although the survival benefit of pembrolizumab was proven in the well‐designed phase III trial, these data represent only a part of patients due to strictly defined eligibility criteria. The patients' characteristics in the clinical practice are much more heterogenous than those of trial participants. The real‐world experience is useful to validate the trial result and find suitable candidates for the treatment. Similarly, real‐world data plays a significant role in addressing the efficacy and safety of special populations, such as poor performance status or older patients. This review summarizes the real‐world evidence on pembrolizumab for platinum‐refractory UCs and discusses the clinical risk factors and efficacy for trial‐ineligible patients.
Unity that Liberates for an Embodied Mission
Authors: Oviedo Pablo Guillermo 
Published: December 2022

AbstractTaking into account the global and local challenges that we are going through, and from a theological‐historical perspective, the working hypothesis in this article is that the ecumenical movement (as part of missio Dei) helped to produce a scenario in 20th‐century Latin America that we could call “mission incarnated.” This is argued using two historical examples: the interaction and mutual enrichment between Latin American liberation theology and the theology of the Wesleyan tradition; and the ecclesial example of the Methodist Church in Argentina. Finally, some theological and missionary challenges that stem from this history are discussed, being important for the ecumenical movement and the Christian faith communities in Latin America at this key point in time.
The 1921 Founding of the International Missionary Council in the Life of John R. Mott
Authors: Hartley Benjamin L. 
Published: December 2022

AbstractThe beginning of the International Missionary Council (IMC) at Lake Mohonk, New York, in 1921 represented a pivot point in the life of John R. Mott (1865–1955). It symbolized for him and other participants a bold initiative in international missionary collaboration that had ramifications for liberal internationalism well beyond the Christian movement itself. World War I was devastating for millions throughout the world, but for Mott it was also a time where his influence in world affairs grew. This article focuses on the years after the war as a time of many challenges and disappointments for Mott as he struggled with nationalism, racism, and the dire effects of colonialism. Student movements which he championed (the YMCA, the World's Student Christian Federation, and the Student Volunteer Movement) also began to go in theological directions with which Mott sometimes disagreed. Mott further experienced setbacks during these post‐war years in his efforts to promote collaboration in mission. He nonetheless possessed hope for a new era of international missionary cooperation that the IMC had inaugurated.
The International Missionary Council
Authors: Stanley Brian 
Published: December 2022

AbstractThis article reflects on the 40‐year history of the International Missionary Council (IMC) from its formation at Lake Mohonk in 1921 to its integration within the World Council of Churches at the WCC's 3rd Assembly in New Delhi in 1961. It does so by analyzing the explicit or implicit answers that were given within IMC circles to three fundamental theological questions. The first question is: What is the theological basis and justification for the Christian mission to all of humanity? A second question came to be regarded by the first IMC secretary, J. H. Oldham, as of primary importance: What is a Christian view of race and racial justice? A third question lay at the heart of the changing relationship between the IMC and the WCC: To what extent does the mission of the church require its visible unity? In investigating the various answers to these questions given within IMC meetings between 1921 and 1961, the article also pursues a fourth question: What answers did non‐Western church and mission leaders give to these three questions, and were their answers heard by the white Europeans and Americans who directed the IMC throughout its history? The article pays particular attention to the Jerusalem meeting in March–April 1928 and the debates supporting and opposing integration within the WCC at what was technically the first assembly of the IMC in Ghana in December 1957–January 1958.
Pope Francis’ Theology of Mission
Authors: Gregory William P. 
Published: December 2022

AbstractSince his election in 2013, Pope Francis has embarked upon a significant program of teaching, exhortation, and internal church critique aimed at stimulating the missionary reform of the Catholic Church. This article provides an overview of his contributions in this area with attention to his efforts to promote the greater involvement of all the baptized in mission, a deeper spirituality of mission across the church, and renewed practices of proclamation and social outreach. The fundamentally practice‐oriented nature of Francis’ teaching is highlighted and a framework for conceiving the central facets of his mission theology is proposed.