bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuberculosis, a Rare Cause of Hands Tenosynovitis: Two Case Reports
Authors: Çıracıoğlu Ayşe merve , Erdoğan Suheyla Dal , Sarıçimen Gizem , Özgen Merih 
Published: September 2022

Abstract
Introduction: A tenosynovitis is a rare form of tuberculosis. It may be overlooked or misdiagnosed due to non-specific findings. These delays in diagnosis and treatment can cause serious complications. Case Presentation: In these case reports, two patients with complaints of pain and swelling in the wrist flexor tendons received various diagnoses such as inflammatory arthritis and carpal tunnel syndrome. These patients who did not respond to the treatment were diagnosed with tuberculosis tenosynovitis as a result of the microbiological and histopathological evaluation. The patients showed significant improvement with antituberculosis treatment and surgical treatment was not needed. Conclusion: It is important for early diagnosis and prevention of appropriate complications in tuberculosis tenosynovitis.
Neoadjuvant Chemotherapy for Patients with International Federation of Gynecology and Obstetrics Stages IB3 and IIA2 Cervical Cancer: A Multicenter Prospective Trial
Authors: Hu Yingjie , Han Yingyan , Shen Yuanming , Chen Jing , Chen Yaheng , Chen Yile , Tang Junying , Xue Min , Hong Li , Cheng Wenjun , Wang Danbo , Liang Zhiqing , Wang Yifeng , Zhang Qinghua , Xing Hui , Zhang Yu , Yi Cunjian , Yu Zhiying , Chen Youguo , Cui Manhua , Ma Cailing , Yang Hongying , Li Ruizhen , Long Ping , Zhao Yu , Qu Pengpeng , Tao Guangshi , Yang Lihua , Wu Sufang , Liu Zhihua , Yang Ping , Lv Weiguo , Xie Xing , Ma Ding , Wang Hui , Li Kezhen 
Published: September 2022

Abstract
Background
Preoperative neoadjuvant chemotherapy (NACT) has been widely used in developing countries for the treatment of patients with International Federation of Gynecology and Obstetrics (FIGO) stages IB3 and IIA2 cervical cancer. However, the effectiveness of NACT and treatment options for NACT-insensitive patients have been concerning. This study will assess prognostic differences between NACT and primary surgery treatment (PST), determine factors associated with prognosis, and explore better adjuvant treatment modalities for NACT-insensitive patients.
Methods
This study analyzed clinical characteristics, pathological characteristics, treatment options, and follow-up information of 774 patients with FIGO stages IB3 and IIA2 cervical cancer from 28 centers from January 2016 to October 2019 who participated in a multicenter, prospective, randomized controlled trial.
Results
For patients undergoing NACT, the 5-year OS and PFS rate was 85.8% and 80.5% respectively. They were similar in the PST group. There was no significant difference in OS and PFS between clinical response (CR)/partial response (PR) groups and stable disease (SD)/progressive disease (PD) groups. Apart from deep cervical invasion affecting OS for patients undergoing NACT, no other clinical and pathological factors were associated with OS. 97.8% of NACT-insensitive patients opted for surgery. If these patients did not have intermediate- or high-risk factors, whether they had undergone postoperative adjuvant therapy was irrelevant to their prognosis, whereas for patients with intermediate- or high-risk factors, adjuvant chemotherapy resulted in better PFS (chemotherapy vs. no therapy, p<0.001; chemotherapy vs. radiotherapy, p=0.019) and OS (chemotherapy vs. no therapy, p<0.001; chemotherapy vs. radiotherapy, p=0.002).
Conclusions
NACT could be a choice for patients with FIGO stages IB3 and IIA2 cervical cancer. The main risk factor influencing prognosis in the NACT group is deep cervical invasion. After systematic treatment, insensitivity to NACT does not indicate a poorer prognosis. For NACT-insensitive patients, Chinese prefer surgery. Postoperative adjuvant therapy in patients with no intermediate- or high-risk factors does not improve prognosis, and chemotherapy in patients with intermediate- and high-risk factors is more effective than radiation therapy and other treatments.
Trial registration
The study was prospectively registered on ClinicalTrials.gov (NCT03308591); date of registration: 12/10/2017.
Digital Document Analysis Using Weighted Score Convolutional Neural Network and Arc Factored Graph Based Dependency Parsing
Authors: D Rekha D Rekha , V Ramaswamy V Ramaswamy 
Published: September 2022

Abstract
Digital document analysis is one where software analysts review documents for assessing an appraisal theme. Digital document analysis can be utilized for obtaining available documents in order to extract relevant data. Most of the research work focuses on a semi-supervised based framework for better parsing performance and traditional statistical setting. However, an inappropriate selection during digital documents analysis may lead to entire process being falsified there by reducing the overall accuracy. To address this issue, in our work, a novel method called, Weighted Score Convolutional Network and Arc-factored Graph-based Dependency Parsing (WSCN-AGDP) is proposed. WSCN-AGDP is split into two sections. First section is concerned with the extraction of relevant features (i.e., words from sentences) by employing Stouffer’s Weighted Score-based Convolutional Neural Network model. In the second section, using the extracted features, Graph-based Dependency Parsing is performed by utilizing Spearman Correlated Arc-Factored model. Four indices were calculated namely, digital document parsing time, parsing overhead, false positive rate and precision are being used to quantitatively assess and rate the algorithms. Different document sizes acquired from Reuters-21578 dataset are considered. Experiments have been conducted to analyze the methods.
Cellular gp96 upregulates AFP expression by blockade of NR5A2 SUMOylation and ubiquitination in HCC
Authors: Qian Liyuan , Liang Zhentao , Wang Jiuru , Li Xin , Zhao Jingmin , Li Zihai , Chen Lizhao , Liu Yongai , ju Ying , Li Changfei , Meng Songdong , Wang Zihao 
Published: September 2022

Abstract
AFP is the most widely used biomarker for the diagnosis of hepatocellular carcinoma. However, a substantial proportion of HCC patients have either normal or marginally increased AFP levels in serum, and the underlying mechanisms are not fully understood. In the present study, we provided in vitro as well as in vivo evidence that heat shock protein gp96 promoted AFP expression at the transcriptional level in HCC. NR5A2 was identified as a key transcription factor regulated by AFP and its stability was enhanced by gp96. A further mechanistic study by CO-IP, GST-pull down and molecular docking showed the competitive binding of gp96 and SUMO E3 ligase RanBP2 to NR5A2 at the sites spanning from aa 507 to 539. The binding of gp96 inhibited SUMOylating, ubiquitination, and subsequent degradation of NR5A2. In addition, clinical analysis of HCC patients indicated that gp96 expression was positively correlated to serum AFP levels in tumors. Therefore, our study uncovered the novel regulatory mechanism of gp96 on the stability of its client proteins by directly affecting their SUMOylation and ubiquitination. These findings will help in designing more accurate AFP-based HCC diagnosis and progression monitoring approaches.
Early ECMO Initiation as a Bridge for Central Airway Obstruction Patients Caused by Neck and Chest Tumors to Emergency Surgery Operations
Authors: Liang LianJing , Su ShiTong , He YaRong , Peng YaLan , Xu ShuYun , Liu Yang , Zhou YaXiong , Yu HaiFang 
Published: September 2022

Abstract
Central airway obstruction caused by neck and chest tumors is a very dangerous oncological emergency with high mortality. Unfortunately, due to its rare literature, no clear evidences or definitive guidelines are currently available for this life-threating condition. Providing effective airway managements, adequate ventilatory and emergency surgical interventions is very important. However, traditional airway managements and respiratory support has only limited effect. In our center, using extracorporeal membrane oxygenation (ECMO) as a novel approach to manage patient with central airway obstruction caused by neck and chest tumors has been adopted since 2021. We aim to show the feasibility: using early ECMO to manage difficult airway, provide oxygenation and support surgical procedure for patients with critical airway stenosis caused by neck and chest tumors. Clinical records of patients admitted for central airway obstruction caused by neck and chest tumors to the Emergency Department, West China Hospital, Sichuan University from January 2021 to December 2021 were collected. Clinico-pathological characteristics, details of ECMO, surgical management, and outcomes were analyzed. Three patients were admitted; Acute dyspnea and cyanosis were the most frequent symptoms at diagnosis. Laboratory findings showed abnormal descending arterial partial pressure of oxygen (PaO2). Meanwhile, CT always revealed abnormal findings: central airway obstruction caused by neck and chest tumor/mass. All cases (3/3) had definite difficult airway. All cases received ECMO support immediately and emergency surgical procedure. Venovenous ECMO was the common mode for all cases. 3 patients weaned off ECMO successfully without any ECMO-related complications. Mean duration of ECMO was 3 hours (range: 1.5–4.5 hours). Under early ECMO support, difficult airway management and emergency surgical procedure were finished successfully for all cases (3/3). The mean ICU stay was 3.3 days (range: 1–7 days), and the mean general ward stay was 3.3 days (range: 2–4 days). Pathological examination demonstrated the etiology of critical airway stenosis caused by tumors for 3 patients. All patients (3/3) were discharged from hospital and no patients had readmissions. We show that early ECMO initiation is a safe and feasible approach to manage difficult airway for patients with severe central airway obstruction caused by neck and chest tumors. Meanwhile, early ECMO initiation can provide security for airway surgical procedure.
Thrombocytosis in Thalassemia major
Authors: Naeem Mohammad Abdul , Aamir Mohammad , Ijaz Farhat , Amin Nayyar 
Published: September 2022

Abstract

BackgroundTo investigate underlying cause for thrombocytosis in children suffering from Thalassemia major.MethodsA cohort of (n=41) children suffering from Thalassemia major were included in the study. They had a persistent platelet count of > 400x109/l for a period of three months. Primary and secondary cause of thrombocytosis were sought as the underlying pathologies.ResultIn significant percentage (44%) of children no underlying cause for thrombocytosis was detected.ConclusionIn depth studies are required to find cause of thrombocytosis in children suffering from Thalassemia major.
Infection of neonatal mice with the murine norovirus strain WU23 is a robust model to study norovirus pathogenesis
Authors: Karst Stephanie , Peiper Amy , Helm Emily , Nguyen Quyen , Phillips Matthew , Williams Caroline , Shah Dhairya , Tatum Sarah , Iyer Neha , Baldridge Megan 
Published: September 2022

Abstract
Noroviruses are the leading cause of severe childhood diarrhea and foodborne disease worldwide. While they are a major cause of disease in all age groups, infections in the very young can be quite severe with annual estimates of 50,000-200,000 fatalities in children under 5 years old. In spite of the remarkable disease burden associated with norovirus infections in people, very little is known about the pathogenic mechanisms underlying norovirus diarrhea, principally because of the lack of tractable small animal models. The development of the murine norovirus (MNV) model nearly two decades ago has facilitated progress in understanding host-norovirus interactions and norovirus strain variability. However, the model remains limited because MNV strains tested thus far either do not cause intestinal disease or were isolated from extraintestinal tissue, raising concerns about translatability of research findings to human norovirus disease. Consequently, the field lacks a strong model of norovirus gastroenteritis and determinants of norovirus pathogenesis remain poorly defined. Herein, we provide a comprehensive characterization of a new small animal model system for the norovirus field that overcomes prior weaknesses. Specifically, we demonstrate that the WU23 MNV strain isolated from a mouse naturally presenting with diarrhea causes reduced weight gain and acute self-resolving diarrhea in neonatal mice of several inbred mouse lines. Moreover, our findings reveal that norovirus-induced diarrhea is associated with infection of subepithelial cells in the small intestine and systemic spread. Finally, type I interferons (IFN) are critical to protect hosts from norovirus-induced intestinal disease whereas type III IFNs exacerbate diarrhea. This latter finding is consistent with other emerging data implicating type III IFNs in the exacerbation of some viral diseases. This new model system should enable a detailed investigation of norovirus disease mechanisms and serve as a platform for testing antivirals.
Vitamin D attenuates cardiac hypertrophy in rats via mRNA regulation of IL- 6 and its receptor
Authors: Nikkholgh Ahad , Tavakoli Fatemeh , Alborzi Nasrin , Araste Fatemeh 
Published: September 2022

Abstract
Background: Interleukin-6 (IL-6), a pro-inflammatory cytokine, plays an important role in the pathogenesis of myocardial hypertrophy. By integrating its membrane receptor complex (gp-80), IL-6 activates the signal guidance components (gp-130) and activates the hypertrophic signaling pathways. There is some evidence that 1, 25 dihydroxyvitamin D exerts anti-hypertrophic effects, but the cellular and molecular mechanisms are not fully understood. The aim of this study was to evaluate the effect of calcitriol on the level of IL-6 and its receptor components in hypertrophied rat heart.
Methods: Male rats were divided into control, hypertrophy, vitamin D+hypertrophy, and propylene glycol+hypertrophy groups. The groups receiving vitamin D and propylene glycol were treated two weeks before induction of hypertrophy and two weeks after hypertrophy. Myocardial hypertrophy was induced by abdominal aortic stenosis. Mean arterial blood pressure was measured by cannulation of the left carotid artery and expression of genes was determined by RT-PCR.
Results: Blood pressure and heart to body weight ratio increased in hypertrophic groups compared to the control group (P<0. 01), but vitamin D administration decreased these parameters (P<0.05). Abdominal aortic stenosis increased IL-6 expression levels (P<0.001) and Vitamin-D decreased IL-6 mRNA levels (P<0.01). The expression of gp-80 in the hypertrophic group increased compared to the control group (P˂0.05) but vitamin D did not affect the expression of receptor subunits genes.
Conclusions: The data from this study suggest a possible mechanism for the anti-hypertrophic effects of vitamin D through the regulation of inflammatory responses during hypertrophy. Thus, vitamin D can reduce IL-6 expression levels, thereby reducing hypertrophy.
Oral ibuprofen versus oral ketorolac for children with moderate and severe acute traumatic pain: a randomized comparative study
Authors: Ghirardo Sergio , Trevisan Matteo , Ronfani Luca , Zanon Davide , Maestro Alessandra , Barbieri Francesca , De Nardi Laura , Amaddeo Alessandro , Barbi Egidio , Cozzi Giorgio 
Published: September 2022

Abstract
Purpose: Compare ibuprofen and ketorolac for children with trauma-related acute pain.
Methods: We conducted a multicentre randomized, double-blind, controlled trial in the Paediatric Emergency Department setting. We enrolled patients aged 8 to 17 who accessed the emergency department for pain related to a limb trauma that occurred in the previous 48 hours. At the admission, patients were classified based on numeric rating scale-11 (NRS-11) in moderate (NRS 4-6) and severe (NRS 7-10) pain groups. Each patient was randomized to receive either ibuprofen (10 mg/kg) or ketorolac (0.5 mg/kg) and the placebo of the not given drug in a double dummies design. NRS-11 was asked every 30 minutes until 2 hours after drug and placebo administration. The primary outcome was NRS-11 reduction at 60 minutes.
Results: Among 125 patients with severe pain, NRS-11 reduction after 60 minutes from drug administration was 2.0 (IQR 1.0-4.0) for ibuprofen and 1.0 (IQR 1.0-3.0) for ketorolac (p=0.36). Ibuprofen was significantly better, considering secondary outcomes, at 90 minutes with a lower median of NRS-11 (p 0.008), more patients with NRS-11 less than 4 (p 0.01) and a reduction of pain score of more than 3 NRS-11 points (p 0.01).
Among 87 patients with moderate pain, the NRS-11 reduction after 60 minutes from drug administration was 1.63 (±1.8) for ibuprofen and 1.8 (±1.6) for ketorolac, with no statistically significant difference.
Conclusions: Oral ibuprofen and ketorolac are similarly effective in children and adolescents with acute traumatic musculoskeletal pain.
ClinicalTrial.gov registration number: NCT04133623
Interaction between Polymorphism of MTHFR C677 Gene and Riboflavin Intake as the Risk of Hypertension in a Region with High Prevalence
Authors: Sukmawan Renan , Hendrik Praise , Zahara Rita , Harlyjoy Beta , Setiani Rissa , - Taofan , Zamroni Dian , Widyantoro Bambang 
Published: September 2022

Abstract
Methylenetetrahydrofolate Reductase (MTHFR) C677T gene polymorphism is associated with decreased MTHFR enzyme activity that leads to hyperhomocysteinemia and hypertension. The MTHFR C677T polymorphism is also associated with lower affinity and faster unbinding of flavin adenine dinucleotide, a riboflavin-derived cofactor for MTHFR enzyme. Natuna is a district which once reported has the highest prevalence of hypertension in Indonesia, based on a national basic health research. Therefore, this study aims to investigate the association between MTHFR C677T polymorphism and riboflavin intake with hypertension in the Natuna district population. An analytic cross-sectional population study was conducted in the region. Data of demographic, physical examination, and food recall, as well as MTHFR genotyping from blood samples of study subjects were collected. The subjects were 268 adults, among which 128 (45.9%) had hypertension, 49 (17.5%) had mutant allele of MTHFR genotype (CT or TT), and 158 (56.4%) had low daily riboflavin intake. There was association between MTHFR C677T polymorphism and hypertension [OR 3.387 (1.724 – 6.654), p = 0.001]. Post-hoc analysis showed that group of mutant MTHFR C677T genotype with low riboflavin intake showed strong association with hypertension [OR 19.320 (4.498–82.980), p<0.01]. Meanwhile, group with mutant MTHFR C677T genotype and normal riboflavin intake did not show a significant association with hypertension. As a conclusion, there was association between interaction of riboflavin intake and MTHFR C677T polymorphism with hypertension. This suggests possibility of riboflavin supplementation in population with high prevalence of hypertension especially those with MTHFR C677T gene polymorphism
A new SEIRPV mathematical model to study the evolution of Covid-19 in Morocco
Authors: BOUISSA Ayoub , TSOULI Najib 
Published: September 2022

Abstract
A new pandemic was discovered in Wuhan, China, in December 2019, this disease belongs to the coronavirus family and has spread rapidly to all countries in the world. As of March 05, more than 1161586 cases have been detected in Morocco, resulting in 16015 deaths with more than 1142892 recoveries. The objective of this paper is to propose a general fractional order SEIRPV model to study the dynamic behavior of COVID-19, and emphasizes the role of the environmental reservoir in the transmission and spread of this disease. This paper also allows us to study the effect of confinement of the susceptible population. Using some mathematical models and conditions, we can conclude that if R0 ≤ 1, the disease-free equilibrium point is unique and locally asymptotically stable as well as globally stable. When R0 > 1, the pandemic equilibrium point is also unique. In addition, the local asymptotic stability of the disease-free and pandemic equilibrium points exists, as well as the global stability. The theoretical results are validated through some numerical simulations to illustrate the evolution of the virus in Morocco using a Matlab program.
Balanced coexistence of reversible and irreversible covalent bonds in a conductive triple polymeric network enables stretchable hydrogel with high toughness and adhesiveness
Authors: Park Kyuha , Kang Kyumin , Kim Jungwoo , Jin Subin , Shin Mikyung , Son Donghee 
Published: September 2022

Abstract
The application of soft hydrogels to stretchable devices has attracted increasing attention in deformable bioelectronics owing to their unique characteristic, “modulus matching between material and organ.” Despite considerable progress, their low toughness, low conductivity, and absence of tissue adhesiveness remain substantial challenges associated with unstable skin-interfacing, where body movements undesirably disturb electrical signal acquisitions. Herein, we report a material design of a highly tough strain-dissipative and skin-adhesive conducting hydrogel fabricated through a facile one-step sol-gel transition and its application to an interactive human-machine interface. The hydrogel comprises a triple polymeric network where irreversible amide linkage of polyacrylamide (PAAm) with alginate (Alg) and dynamic covalent bonds entailing conjugated polymer chain of poly(3,4 ethylenedioxythiophene)-co-(3-thienylboronic acid) (p(EDOT-co-TBA)) are simultaneously capable of high stretchability (1,300% strain), efficient strain dissipation (36,209 J/m2), low electrical resistance (590 Ω), and even robust skin adhesiveness (35.0 ± 5.6 kPa). Based on such decent characteristics, the hydrogel was utilized as a multifunctional layer for successfully performing either electrophysiological cardiac/muscular on-skin sensors or an interactive stretchable human-machine-interface.
Learning from pandemic: IMCU as a more efficient model of pediatric critical care organization
Authors: Brisca Giacomo , Tardini Giacomo , Pirlo Daniela , RomanengoMD Marta , Buffoni Isabella , Mallamaci Marisa , Carrato Valentina , Lionetti Barbara , Molteni Marta , Castagnola Elio , Moscatelli Andrea 
Published: September 2022

Abstract
Purpose:A variable proportion of children with COVID-19-related illness required pediatric intensive care admission (ICU), although, in many cases, only for monitoring, frequent and complex therapies, or for concerns related to relevant comorbidities or young age. This may have determined inappropriate admissions, waste of resources, ICU overcrowding and psychological effects on children and families.
Pediatric Intermediate Care Unit (IMCU) may represent an appropriate unit to care for children who need monitoring and treatment beyond what can be offered in a general pediatric floor but do not qualify for pediatric ICU admission.
Methods:We conducted a single-center retrospective study of all patients aged 0-18 with acute COVID-19 or meeting diagnostic criteria for multisystem inflammatory syndrome in children, admitted to a newly established pediatric IMCU at Gaslini Hospital, Genoa, Italy, between 1 March 2020 and 31 January 2022.
Results:Among 550 patients hospitalized for acute COVID-19 or MIS-C, 106 (19.2%) were admitted to IMCU. Three patients (2.8%) needed escalation to intensive care. Overall, the need for pediatric ICU admission was considerably low for both acute COVID-19 patients (0.8%) and MIS-C patients (3.1%) compared to literature data.
Conclusions: The IMCU represented an adequate setting for COVID-19 children who needed a higher level of care, but not requiring critical care, thus allowing
better ICU bed utilization and cost savings. Further studies are needed to better assess the impact of an IMCU on hospital costs, ICU activity, and long-term psychological effect among children and their families.