bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated With an Intra-articular Infection After Anterior Cruciate Ligament Reconstruction: A Large Single-Institution Cohort Study
Authors: Marom Niv , Kapadia Milan , Nguyen Joseph T. , Ammerman Brittany , Boyle Caroline , Wolfe Isabel , Halvorsen Kristin C. , Miller Andy O. , Henry Michael W. , Brause Barry D. , Hannafin Jo A. , Marx Robert G. , Ranawat Anil S. 
Published: March 2022

Background: An intra-articular infection after anterior cruciate ligament (ACL) reconstruction (ACLR) is a rare complication but one with potentially devastating consequences. The rare nature of this complication raises difficulties in detecting risk factors associated with it and with worse outcomes after one has occurred. Purpose: To (1) evaluate the association between an infection after ACLR and potential risk factors in a large single-center cohort of patients who had undergone ACLR and (2) assess the factors associated with ACL graft retention versus removal. Study Design: Case-control study; Level of evidence, 3. Methods: All ACLR procedures performed at our institution between January 2010 and December 2018 were reviewed; a total of 11,451 procedures were identified. A retrospective medical record review was performed to determine the incidence of infections, patient and procedure characteristics associated with an infection, infection characteristics, incidence of ACL graft retention, and factors associated with the retention versus removal of an ACL graft. Multivariable logistic regression analysis was used to identify potential risk factors for an infection after ACLR. Results: Of the 11,451 ACLR procedures, 48 infections were identified (0.42%). Multivariable logistic regression analysis revealed revision ACLR (odds ratio [OR], 3.13 [95% CI, 1.55-6.32]; P = .001) and younger age (OR, 1.06 [95% CI, 1.02-1.10]; P = .001) as risk factors for an infection. Compared with bone–patellar tendon–bone autografts, both hamstring tendon autografts (OR, 4.39 [95% CI, 2.15-8.96]; P < .001) and allografts (OR, 5.27 [95% CI, 1.81-15.35]; P = .002) were independently associated with an increased risk of infections. Overall, 15 ACL grafts were removed (31.3%). No statistically significant differences besides the number of irrigation and debridement procedures were found for retained versus removed grafts, although some trends were identified ( P = .054). Conclusion: In a large single-center cohort of patients who had undergone ACLR and those with an infection after ACLR, patients with revision cases and younger patients were found to have a higher incidence of infection. The use of bone–patellar tendon–bone autografts was found to be associated with the lowest risk of infection after ACLR compared with both hamstring tendon autografts and allografts. Larger cohorts with a larger number of infection cases are needed to determine the factors associated with graft retention versus removal.
Evaluation of voriconazole related adverse events in pediatric patients with hematological malignancies
Authors: Ertem Ozge , Tufekci Ozlem , Oren Hale , Tuncok Yesim , Ergon Mahmut Cem , Gumustekin Mukaddes 
Published: March 2022

Background Despite therapeutic drug monitoring and pharmacogenetic-guided dose selection are recommended for pediatric patients, safety of voriconazole is mostly monitored by clinical assessment. Having comprehensive knowledge of safety profile and distinguishing incidental events from the reactions that are truly related to voriconazole use are crucial for safer and uninterrupted treatment. Objectives This study aimed to address adverse reactions during the first month of voriconazole use by systematically evaluating retrospective records of all adverse events. Patients/Methods: It is a single-center, retrospective analysis of patients who received voriconazole from 1 September 2010 to 1 September 2020. Severity of abnormal findings in medical records were systematically graded. Causality between voriconazole and the events was evaluated by Liverpool Causality Assessment Tool (LCAT), Naranjo Algorithm and World Health Organization Causality Assessment System. The events with possible or probable causal relation to voriconazole are classified as adverse reaction. Results Records of 45 patients included in the study. The overall frequency of adverse reactions was 51.1%. Hepatobiliary laboratory adverse reactions identified in 48.9% of the patients and led to treatment discontinuation in 20.0%. Amylase and lipase elevation (2.2%), ventricular extra systoles (2.2%), hallucination and nightmares (2.2%) were other adverse reactions. Conclusions Hepatobiliary abnormalities were the most common adverse reactions and the most common cause of treatment discontinuation. For safer treatment in critically ill patients, the dose should be personalized. To clearly identify the accurate frequency and the causality of all adverse reactions, prospective studies with much larger sample size are needed.
Serum neurofilament light-chain levels in children with monophasic myelin oligodendrocyte glycoprotein-associated disease, multiple sclerosis, and other acquired demyelinating syndrome
Authors: Wendel Eva-Maria , Bertolini Annikki , Kousoulos Lampros , Rauchenzauner Markus , Schanda Kathrin , Wegener-Panzer Andreas , Baumann Matthias , Reindl Markus , Otto Markus , Rostásy Kevin 
Published: March 2022

Objective: To assess the diagnostic and prognostic potential of serum neurofilament light chain (sNfL) in children with first acquired demyelinating syndrome (ADS). Methods: We selected 129 children with first ADS including 19 children with myelin oligodendrocyte glycoprotein (MOG)-antibody associated disease (MOGAD), 36 MOG/AQP4-seronegative ADS, and 74 with multiple sclerosis (MS) from the BIOMARKER study cohort. All children had a complete set of clinical, radiological, laboratory data and serum for NfL measurement using a highly sensitive digital ELISA (SIMOA). A control group of 35 children with non-inflammatory neurological diseases was included. sNfL levels were compared across patient groups according to clinical, laboratory, neuroradiological features and outcome after 2 years. Results: sNfL levels were significantly increased in MOGAD, seronegative ADS and MS compared to controls ( p-value < 0.001), in particular in children with an acute disseminated encephalomyelitis (ADEM)-like magnetic resonance imaging (MRI) pattern ( p < 0.001) or longitudinally extensive myelitis ( p < 0.01). In pediatric MS, elevated sNfL levels were significantly associated with higher numbers of cerebral ( p < 0.001) and presence of spinal ( p < 0.05) MRI lesions at baseline and predicted a higher number of relapses ( p < 0.05). Conclusion: sNfL levels are significantly elevated in all three studied pediatric ADS subtypes indicating neuroaxonal injury. In pediatric MS high levels of sNfL are associated with risk factors for disease progression.
Unsteady characteristics of sleeping thermal comfort during defrosting of a T-ASHP system
Authors: Mao Ning , Yu Hao , He Tianbiao , Xu Yingjie 
Published: March 2022

Defrosting is necessary for the normal operation of air source heat pump (ASHP) units to solve the frosting in the winter, which deteriorates the performance of ASHP. During this defrosting period, the ASHP cannot provide heat to the indoor space, leading to adverse thermal comfort, which may reduce the sleep quality. Hence, a task/ambient ASHP (T-ASHP) system was designed in this study, and the transient thermal environment was investigated through a computational fluid dynamic (CFD) method. The duration of t oz (average air temperature in the occupied zone) increase period was 4.33 times as long as t oz decrease period, although the duration of the phase 1 heating period was 1.9 times as that of defrosting period. During the defrosting procedure, the PMV value decreased to the lowest value of −0.83, and the period of feeling cool and slightly cool lasted for 45.4 min. The hand, foot and leg parts were much cooler than the whole body, and the non-uniformity of the PMV value on body parts was obviously enlarged during the defrosting period. Higher draught risk around 22% near the head and trunk regions was found during the defrosting period and was significantly reduced in the follow-up heating period. Practical application: The results from this study emphasize the sleeping thermal comfort during defrosting of air source heat pumps. The present study gave a map of transient thermal comfortable levels influenced by the operating of defrosting and re-heating. These results should serve as a recommendation to air source heat pump designers to determine suitable defrosting technology to maintain normal indoor thermal comfort.
Predictors of Digital Amputation in Diabetic Patients With Surgically Treated Finger Infections
Authors: Gibson Ella , Bettlach Carrie R. , Payne Emma , Daines John , Vuong Linh , Merrill Corinne , Fox Ida K. , Pet Mitchell A. 
Published: March 2022

Background: Diabetes is a well-established risk factor for severe digital infection, and patients are more likely to require digital amputation for adequate source control. This study aims to identify factors predictive of digital amputation compared with preservation in patients with diabetes who present with surgically treated finger infections. Methods: Current Procedural Terminology (CPT) and International Classification of Diseases Versions 9 and 10 (ICD-9/10) databases from a single academic medical center were queried to identify patients with type 1 or type 2 diabetes mellitus who underwent surgical treatment in the operating room for treatment of a digital infection from 2010 to 2020. Electronic medical records were reviewed to obtain historical and acute clinical variables at the time of hospital presentation. Bivariate and multivariable regression were used to identify factors associated with amputation. Results: In total, 145 patients (61 digital amputation, 84 digital preservation) met inclusion criteria for this retrospective cohort study. Mean hospital stay was 6 days, and the average patient underwent 2 operations. Multivariable analysis revealed that the presence of osteomyelitis, ipsilateral upper extremity dialysis fistula, end-stage renal disease, and vascular disease each had significant independent predictive value for amputation rather than digital preservation. Conclusions: Digital amputation is common in the setting of diabetic finger infection. The 4 variables found to independently predict the outcome of amputation can be understood as factors which decrease the likelihood of successful digital salvage and increase the potential consequence of ongoing uncontrolled infection. Further study should focus on clinical factors affecting surgical decision making and how the treatment rendered affects patient outcomes.
Benefit from successful recanalization in an Italian cohort of stroke patients receiving endovascular treatments according to the DIRECT-MT trial criteria
Authors: Cappellari Manuel , Saia Valentina , Pracucci Giovanni , Sallustio Fabrizio , Zini Andrea , Bergui Mauro , Zivelonghi Cecilia , Mangiafico Salvatore , Toni Danilo 
Published: March 2022

Introduction To identify predictors of 3-month mRS score and to estimate the benefit from successful recanalization across baseline subgroups of Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS) cohort of stroke patients receiving endovascular treatments according to the DIRECT-MT criteria. Methods Using a model of propensity score matching, we retrospectively identified an IRETAS cohort of 137 patients receiving bridging who were matched with 137 patients receiving MT alone according to the DIRECT-MT criteria. Results Differences were found between DIRECT-MT and IRETAS cohorts for 3-month mRS score 0 to 1 (23.5% vs. 33.1%) and 0 to 2 (36.7% vs. 47.1%), successful (82% vs. 76.7%) and complete recanalization (32.3% vs. 58.8%). Among unfavorable predictors for 3-month mRS shift, diabetes mellitus (18.9% vs. 13.9%) and asymptomatic intracerebral hemorhage (ICH) (34.8% vs. 25.5%) were more frequent in the DIRECT-MT, whereas age ≥80 years (23.7% vs. 15.3%) and pre-stroke mRS score >0 (16.1% vs. 7.8%) were more frequent in the IRETAS. The direction of effect on the 3-month mRS shift (6 to 0) favored successful recanalization across all strata. Greatest benefit from successful recanalization was observed in patients with most severe strokes (NIHSS ≥20, OR:4.002; 16–19, OR:3.292; 2–5, OR:2.470) and most proximal occlusion site (intra-cranial ICA, OR:4.092; M1-MCA, OR:3.705; M2-MCA, OR:2.001), in younger patients (18–59 years, OR:3.677; 60–79, OR:3.267; ≥80, OR:1.993), and in patients who started the treatment earlier (onset-to-groin time ≤205 min, OR:4.361; onset-to-groin time >205, OR:2.326). Conclusions The benefit from successful recanalization for 3-month mRS shift in the direction of favorable outcome was different across baseline subgroups.
Puerperal sepsis-related knowledge and reported self-care practices among postpartum women in Dar es salaam, Tanzania
Authors: Nchimbi Dorice B , Joho Angelina A 
Published: March 2022

Background: Knowledge and reported self-care practices of postpartum women are important for early detection, prevention and treatment of puerperal sepsis. Objectives: This study analyzes the knowledge and self-care practices for prevention of puerperal sepsis and their determinants among postpartum women. Methods: A hospital-based analytical cross-sectional study which included 343 postpartum women was conducted from February to March 2021. Data were collected using interviewer-administered questionnaire. Predictors of knowledge and self-care reported practice were determined using binary logistic regression. p < 0.05 was considered significant. Results: More than half ( n = 213, 62.1%) of the postpartum women had adequate knowledge on prevention of puerperal sepsis. Only 39 (11.4%) of the women reported adequate self-care practices toward prevention of puerperal sepsis. Secondary education (adjusted odds ratio = 0.18, 95% confidence interval = 0.06–0.49, p = 0.001), tertiary education (adjusted odds ratio = 0.52, 95% confidence interval = 0.19–1.38, p = 0.021) and getting information from healthcare providers (adjusted odds ratio = 1.06, 95% confidence interval = 0.55–2.06, p = 0.049) were significant determinants of knowledge on prevention of puerperal sepsis. Also, secondary education (adjusted odds ratio = 0.11, 95% confidence interval = 0.04–0.30, p = 0.001), tertiary education (adjusted odds ratio = 0.16, 95% confidence interval = 0.06–0.39, p = 0.001), and having more than four antenatal care visits (adjusted odds ratio = 1.21, 95% confidence interval = 0.49–3.27, p = 0.041) were significant determinants of reported self-care practices for prevention of puerperal sepsis. Conclusion: A significant gap in reported self-care practices to prevent puerperal sepsis was evidence. Secondary and tertiary education were significant predictors for both knowledge and self-care reported practices. Special attention should be given to women with low education level.
The Whiston Snare Technique for Loop Extraction of Stents (WHISTLES): A novel technique for the intraureteric assembly of a loop snare for the retrograde extraction of a migrated ureteric stent
Authors: Napier-Hemy Timothy Peter , Floyd Michael S , Samsudin Azizan 
Published: March 2022

Background: While ureteric stent removal remains a frequently performed endourological procedure stent migration either proximally or distally can present the endourologist with a significant intraoperative dilemma. In cases where the stent is of large calibre or impacted into the mucosa of the ureter, retrieval may prove refractory to traditional approaches. Objective: To present a further novel procedure: The Whiston Snare Technique for Loop Extraction of Stents (WHISTLES) which allows for intraureteric assembly of a tightening loop through a ureteric catheter thus permitting safe retrieval of a migrated stent. Methods: We describe the procedure as it was performed and have recreated the steps in a laboratory environment. This demonstrates an adaptation of existing materials readily found in most urological theatres and is not a prototypical device. Results: The procedure was successfully performed to allow extraction of the migrated ureteric stent. Conclusion: WHISTLES is a reproducible method for the retrieval of migrated ureteric stents where traditional techniques have failed. Level of evidence: 5
Indoor positioning systems in hospitals: A scoping review
Authors: Wichmann Johannes 
Published: March 2022

BackgroundIndoor navigation within closed facilities has been subject of studies with different application areas, particularly in recent years (e.g. the navigation requirements of people or the location of objects). Hospitals are of specific interest in this regard as the multitude of technical equipment used is potentially interfering with navigation systems.ObjectiveThis research examines relevant studies regarding Indoor Positioning Systems (IPS) in hospitals and IPS that are designed for hospitals and in preparation for implementation, by investigating the respective technologies, techniques, prediction-improving methods, evaluation results, and limitations of the IPS.MethodsTo gather current and future IPS in hospitals, the methodology of a Scoping Review was used. The study has been conducted by applying the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Framework to the context of IPS in hospitals. The results and limitations concerning current and future IPS in hospitals were gathered and structured by using a highly cited evaluation framework for IPS.ResultsThirty-eight studies were considered for this research. The IPS technologies investigated were Bluetooth Low Energy ( n = 17), Wireless-Fidelity ( n = 10), Hybrids ( n = 4), Radio-Frequency Identification ( n = 4), Ultra-Wideband ( n = 1), Infrared ( n = 1) and ZigBee ( n = 1).ConclusionsThis study presents current and future IPS in hospitals. For future IPS research and IPS in hospitals, the theoretical implications contribute to our knowledge about IPS technologies, techniques, prediction-improving methods, evaluation results and limitations during testing/implementing IPS in hospitals. As practical implications, the insights of this study can be used by developers to improve IPS and by hospitals to facilitate IPS implementation.
Subjective theories of illness in fibroid and endometriosis patients: Similarities, differences, and influencing factors
Authors: Münch Friederike , Ebert Andreas D , Mechsner Sylvia , Richter Rolf , David Matthias 
Published: March 2022

Introduction: The aim of this study was to compare the subjective theories of illness in patients with fibroids and patients with endometriosis, and to identify potential factors influencing them. Methodology: Participating patients were recruited via three specialized centers for fibroids and endometriosis. To assess their subjective theories concerning the cause of their illness, we used a questionnaire based on the revised Illness Perceptions Questionnaire (IPQ-R). We also gathered and evaluated data relating to sociodemographic factors and psychological distress or possible anxieties using the Kessler Psychological Distress Scale (K10) and the Generalised Anxiety Disorder Assessment (GAD-7). Results: We were able to analyze data from 201 patients with fibroids and 212 patients with endometriosis. About 94.4% of the patients had one or more subjective theories concerning the cause of their illness. Both groups perceived “stress or worry” to be the most probable cause of their illness. Compared to endometriosis patients, patients with fibroids were more likely to assume “aging” and “heredity” as the cause of their illness. Endometriosis patients, on the other hand, were more likely to choose theories pertaining to the “environmental influences and immune system” category. The patients’ age, formal education, and conspicuous score values in the K10 or GAD-7 questionnaire proved to be important factors influencing their beliefs about the cause of illness. Conclusion: Patients perceive stress and psychological strain as possible causes for their illness. It might be beneficial to take this information into account in conversations between doctors and patients and when drawing up psychosomatic-gynecological treatment plans.
How I manage pregnancy in women with Glanzmann thrombasthenia
Authors: Fiore Mathieu , Sentilhes Loïc , d’Oiron Roseline 
Published: March 2022

AbstractGlanzmann thrombasthenia (GT) is a rare inherited platelet function disorder caused by a quantitative and/or qualitative defect of the αIIbβ3 integrin. Pregnancy and delivery are recognized risk periods for bleeding in women with GT. The newborn may also be affected by fetal and neonatal immune thrombocytopenia induced by the transplacental passage of maternal anti-αIIbβ3 antibodies, which can lead to severe hemorrhage and fetal loss. Pregnancy in women with GT thus requires a multidisciplinary approach, including prepregnancy counseling and a treatment plan for delivery for both the mother and child. In this article, we summarize the current knowledge on pregnancy in women with GT and describe how we manage this severe platelet disorder in our clinical practice.
HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression
Authors: Li Liping , Kim Jung-Hyun , Lu Wenyan , Williams Donna M. , Kim Joseph , Cope Leslie , Rampal Raajit K. , Koche Richard P. , Xian Lingling , Luo Li Z. , Vasiljevic Marija , Matson Daniel R. , Zhao Zhizhuang Joe , Rogers Ophelia , Stubbs Matthew C. , Reddy Karen , Romero Antonio-Rodriguez , Psaila Bethan , Spivak Jerry L. , Moliterno Alison R. , Resar Linda M. S. 
Published: March 2022

Abstract
Myeloproliferative neoplasms (MPNs) transform to myelofibrosis (MF) and highly lethal acute myeloid leukemia (AML), although the actionable mechanisms driving progression remain elusive. Here, we elucidate the role of the high mobility group A1 (HMGA1) chromatin regulator as a novel driver of MPN progression. HMGA1 is upregulated in MPN, with highest levels after transformation to MF or AML. To define HMGA1 function, we disrupted gene expression via CRISPR/Cas9, short hairpin RNA, or genetic deletion in MPN models. HMGA1 depletion in JAK2V617F AML cell lines disrupts proliferation, clonogenicity, and leukemic engraftment. Surprisingly, loss of just a single Hmga1 allele prevents progression to MF in JAK2V617F mice, decreasing erythrocytosis, thrombocytosis, megakaryocyte hyperplasia, and expansion of stem and progenitors, while preventing splenomegaly and fibrosis within the spleen and BM. RNA-sequencing and chromatin immunoprecipitation sequencing revealed HMGA1 transcriptional networks and chromatin occupancy at genes that govern proliferation (E2F, G2M, mitotic spindle) and cell fate, including the GATA2 master regulatory gene. Silencing GATA2 recapitulates most phenotypes observed with HMGA1 depletion, whereas GATA2 re-expression partially rescues leukemogenesis. HMGA1 transactivates GATA2 through sequences near the developmental enhancer (+9.5), increasing chromatin accessibility and recruiting active histone marks. Further, HMGA1 transcriptional networks, including proliferation pathways and GATA2, are activated in human MF and MPN leukemic transformation. Importantly, HMGA1 depletion enhances responses to the JAK2 inhibitor, ruxolitinib, preventing MF and prolonging survival in murine models of JAK2V617F AML. These findings illuminate HMGA1 as a key epigenetic switch involved in MPN transformation and a promising therapeutic target to treat or prevent disease progression.