bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recognition & management of varicella infections and accuracy of antimicrobial recommendations: Case vignettes study in the US
Authors: Fergie Jaime , Pawaskar Manjiri , Veeranki Phani , Samant Salome , Harley Carolyn , MacEwan Joanna , Schwartz Taylor T. , Surati Shikha , Conway James H. 
Published: June 2022

Background
In 1995, the CDC recommended one-dose routine varicella immunization for children <12 years of age, expanding its recommendation to two doses in 2006. Today, with widespread varicella vaccination coverage, an estimated 3.5 million cases of varicella, 9,000 hospitalizations, and 100 deaths are prevented annually in the United States. Since varicella infections are now uncommon, health care providers (HCPs) may not recognize varicella infections and may prescribe inappropriate treatment.

Methods
An online survey of HCPs was conducted to assess recognition and management of varicella infections. Responses to eight varicella vignettes describing patients with varying varicella symptoms were analyzed and descriptive analyses performed. Stratified analysis comparing responses of those licensed before and in/after 1996 was also performed.

Results
153 HCPs (50 nurse practitioners, 103 doctors) completed the survey. Mean age of respondents was 44 years. 62% were female, and 82% were licensed before 1996. Varicella infection was correctly diagnosed 79% of the time. HCPs correctly recognized uncomplicated varicella vignettes 85% of the time versus 61% of the time for complicated varicella vignettes. Antibiotics were recommended 17% of the time and antivirals 18% of the time, of which 25% and 69% (respectively) were not appropriate per guidelines. HCPs licensed before 1996 were better able to recognize varicella compared to those licensed later, but prescribed more antimicrobials medications to treat varicella.

Conclusions
Although most HCPs recognized varicella infection, a sizable proportion could not recognize cases with complications, and some of the varicella cases were inappropriately treated with antibiotics and/or antivirals. Additional HCP training and high vaccination coverage are important strategies to avoid inaccurate diagnoses and minimize unnecessary exposure to antimicrobial/antiviral therapies.
Spatial environmental factors predict cardiovascular and all-cause mortality: Results of the SPACE study
Authors: Hadley Michael B. , Nalini Mahdi , Adhikari Samrachana , Szymonifka Jackie , Etemadi Arash , Kamangar Farin , Khoshnia Masoud , McChane Tyler , Pourshams Akram , Poustchi Hossein , Sepanlou Sadaf G. , Abnet Christian , Freedman Neal D. , Boffetta Paolo , Malekzadeh Reza , Vedanthan Rajesh 
Published: June 2022

Background
Environmental exposures account for a growing proportion of global mortality. Large cohort studies are needed to characterize the independent impact of environmental exposures on mortality in low-income settings.

Methods
We collected data on individual and environmental risk factors for a multiethnic cohort of 50,045 individuals in a low-income region in Iran. Environmental risk factors included: ambient fine particular matter air pollution; household fuel use and ventilation; proximity to traffic; distance to percutaneous coronary intervention (PCI) center; socioeconomic environment; population density; local land use; and nighttime light exposure. We developed a spatial survival model to estimate the independent associations between these environmental exposures and all-cause and cardiovascular mortality.

Findings
Several environmental factors demonstrated associations with mortality after adjusting for individual risk factors. Ambient fine particulate matter air pollution predicted all-cause mortality (per μg/m3, HR 1.20, 95% CI 1.07, 1.36) and cardiovascular mortality (HR 1.17, 95% CI 0.98, 1.39). Biomass fuel use without chimney predicted all-cause mortality (reference = gas, HR 1.23, 95% CI 0.99, 1.53) and cardiovascular mortality (HR 1.36, 95% CI 0.99, 1.87). Kerosene fuel use without chimney predicted all-cause mortality (reference = gas, HR 1.09, 95% CI 0.97, 1.23) and cardiovascular mortality (HR 1.19, 95% CI 1.01, 1.41). Distance to PCI center predicted all-cause mortality (per 10km, HR 1.01, 95% CI 1.004, 1.022) and cardiovascular mortality (HR 1.02, 95% CI 1.004, 1.031). Additionally, proximity to traffic predicted all-cause mortality (HR 1.13, 95% CI 1.01, 1.27). In a separate validation cohort, the multivariable model effectively predicted both all-cause mortality (AUC 0.76) and cardiovascular mortality (AUC 0.81). Population attributable fractions demonstrated a high mortality burden attributable to environmental exposures.

Interpretation
Several environmental factors predicted cardiovascular and all-cause mortality, independent of each other and of individual risk factors. Mortality attributable to environmental factors represents a critical opportunity for targeted policies and programs.
Revealed consumers’ preferences for fresh produce attributes in Chinese online markets: A case of domestic and imported apples
Authors: Wang H. Holly , Han Xiao , Jiang Yu , Wu Guoyong 
Published: June 2022

Background
The online market is getting popular today, and consumers’ preferences about products are revealed differently in online and offline markets. Especially, fresh food purchasing online is very different from non-food products due to its unique features such as perishability, low cost and frequent purchases, low value-volume ratio, and highly relevance to safety and health. However, studies on online fresh food are rather few, and this study will fill the gap by investigating consumers’ preferences for fresh food online purchasing.

Methods
Using unique data observed from online stores, we conduct a hedonic analysis of fresh produce online market using apple market in China, avoiding hypothetical bias. Propensity Score Matching is used to check the online promotion effects. The data are apples transactions from Jingdong JD e-commerce platform with sample size 8,200, observed across six weeks from 11/26/2018 to 12/31/2018. Variables used include prices, promotions, varieties, places of origin, fruit size, labeled as organic or green food, watercore label, and customer reviews for the products as well as for the venders.

Results
We found place of origin, food safety and eco-certificates, and sensory features all influence apple prices which reflect consumer preferences. In addition to product features, store features such as former customers’ review for the store, a video post of the product, and other latent product features through former customers’ review for the product quality also influence consumers’ preference reflected by price.

Conclusions
In additional to product intrinsic features, consumer show preferences and valuation for online market special features.
Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia
Authors: Chandra Rashmi , Aryal Dipendra K. , Douros Jonathan D. , Shahid Rafiq , Davis Supriya J. , Campbell Jonathan E. , Ilkayeya Olga , White Phillip J. , Rodriguez Ramona , Newgard Christopher B. , Wetsel William C. , Liddle Rodger A. 
Published: June 2022

Objective
Immunoglobulin-like Domain-Containing Receptor 1 (ILDR1) is expressed on nutrient sensing cholecystokinin-positive enteroendocrine cells of the gastrointestinal tract and it has the unique ability to induce fat-mediated CCK secretion. However, the role of ILDR1 in CCK-mediated regulation of satiety is unknown. In this study, we examined the effects of ILDR1 on food intake and metabolic activity using mice with genetically-deleted Ildr1.

Methods
The expression of ILDR1 in murine tissues and the measurement of adipocyte cell size were evaluated by light and fluorescence confocal microscopy. The effects of Ildr1 deletion on mouse metabolism were quantitated using CLAMS chambers and by targeted metabolomics assays of multiple tissues. Hormone levels were measured by ELISA. The effects of Ildr1 gene deletion on glucose and insulin levels were determined using in vivo oral glucose tolerance, meal tolerance, and insulin tolerance tests, as well as ex vivo islet perifusion.

Results
ILDR1 is expressed in a wide range of tissues. Analysis of metabolic data revealed that although Ildr1-/- mice consumed more food than wild-type littermates, they gained less weight on a high fat diet and exhibited increased metabolic activity. Adipocytes in Ildr1-/- mice were significantly smaller than in wild-type mice fed either low or high fat diets. ILDR1 was expressed in both alpha and beta cells of pancreatic islets. Based on oral glucose and mixed meal tolerance tests, Ildr1-/- mice were more effective at lowering post-prandial glucose levels, had improved insulin sensitivity, and glucose-regulated insulin secretion was enhanced in mice lacking ILDR1.

Conclusion
Ildr1 loss significantly modified metabolic activity in these mutant mice. While Ildr1 gene deletion increased high fat food intake, it reduced weight gain and improved glucose tolerance. These findings indicate that ILDR1 modulates metabolic responses to feeding in mice.
Prognostic value of sarcopenia in patients with rectal cancer: A meta-analysis
Authors: Zhu Yueli , Guo Xiaoming , Zhang Qin , Yang Yunmei 
Published: June 2022

Background
Sarcopenia is usually characterized by the loss of skeletal muscle mass and impaired muscle function which is commonly seen in the elderly. It has been found to be associated with poorer prognoses in many types of cancer. Computed tomography (CT) scan is frequently used to assess skeletal muscle mass and further calculate skeletal muscle index (SMI) at the third lumbar vertebra level (L3), which is used to define sarcopenia. The purpose of this meta-analysis was to assess the prognostic value of sarcopenia for overall survival (OS) in patients with rectal cancer.

Methods
We performed a systematic search to find relevant studies published up to 14 January 2021 in PubMed, Embase, Web of science and Scopus. In our meta-analysis, studies comparing OS in rectal cancer patients with sarcopenia versus those without were included. Quality assessment for included studies was evaluated according to the Quality in Prognosis Studies (QUIPS) tool. We directly extracted hazard ratios (HRs) with 95% confidence intervals (CIs) in both univariate and multivariate analyses from each study. The Cochrane Collaboration’s Review Manager 5.4 software was applied to analyze data. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines and website GRADEpro.

Results
Finally, a total of 7 studies involving 2377 patients were included. The pooled HRs were 2.10 (95% CI 1.33–3.32, P = 0.001) and 2.37 (95% CI 1.13–4.98, P = 0.02) using random-effects models in univariate and multivariate analyses, respectively. The results showed a significant association between sarcopenia and OS in patients with rectal cancer. The quality of the evidence for OS was moderate for both univariate and multivariate analyses.

Conclusion
CT-defined sarcopenia is an independent predictor for worse OS in patients with rectal cancer. Future studies with a more stringent definition of sarcopenia are required to further confirm our findings.
Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death
Authors: Na Hyun Sik , Woo Jin Seok , Kim Ju Hwan , Lee Jeong Su , Um In Gyu , Cho Keun-Hyung , Kim Ga Hyeon , Cho Mi-La , Chung Sang J. , Park Sung-Hwan 
Published: June 2022

Background
Osteoarthritis (OA) is the most common degenerative joint disease and is characterized by breakdown of joint cartilage. Coenzyme Q10 (CoQ10) exerts diverse biological effects on bone and cartilage; observational studies have suggested that CoQ10 may slow OA progression and inflammation. However, any effect of CoQ10 on OA remains unclear. Here, we investigated the therapeutic utility of CoQ10-micelles.

Methods
Seven-week-old male Wistar rats were injected with monosodium iodoacetate (MIA) to induce OA. CoQ10-micelles were administered orally to MIA-induced OA rats; celecoxib served as the positive control. Pain, tissue destruction, and inflammation were measured. The expression levels of catabolic and inflammatory cell death markers were assayed in CoQ10-micelle-treated chondrocytes.

Results
Oral supplementation with CoQ10-micelles attenuated OA symptoms remarkably, including pain, tissue destruction, and inflammation. The expression levels of the inflammatory cytokines IL-1β, IL-6, and MMP-13, and of the inflammatory cell death markers RIP1, RIP3, and pMLKL in synovial tissues were significantly reduced by CoQ10-micelle supplementation, suggesting that CoQ10-micelles might attenuate the synovitis of OA. CoQ10-micelle addition to cultured OA chondrocytes reduced the expression levels of catabolic and inflammatory cell death markers.

Conclusions
CoQ10-micelles might usefully treat OA.
Calibration and analysis of discrete element simulation parameters of Chinese cabbage seeds
Authors: Wang Shengsheng , Mengqing Lu , Liu Xingyi , Ji Jiangtao , Chen Pan 
Published: June 2022

Objective
To improve the accuracy of parameters used in discrete element simulation test of Chinese cabbage seeds harvesting process.

Methods
Firstly, the key physical parameters of Chinese cabbage seeds were measured. According to the results, the discrete element simulation model was established and the value range of simulation test parameters was determined. Then, the actual repose angle of Chinese cabbage seeds was obtained by physical accumulation test using bottomless conical cylinder lifting method. Plackett-Burman test, steepest climb test, Box-Behnken test and parameter optimization test were carried out in sequence with the actual angle of repose as the response value. Finally, the obtained parameters are verified.

Results
1. The Plackett-Burman test showed that the seed-seed rolling friction coefficient, the seed-steel rolling friction coefficient, the seed-seed static friction coefficient, and the seed-steel static friction coefficient had significant effects on the repose angle of Chinese cabbage seeds (P<0.05). 2. The optimization test showed that the seed-seed rolling friction coefficient was 0.08, the seed-steel rolling friction coefficient was 0.109, the seed-seed static friction coefficient was 0.496, and the seed-steel static friction coefficient was 0.415. 3. The validation test showed that the repose angle of Chinese cabbage seeds under such parameter was 23.62°, and the error with the repose angle of the physical test was 0.73%.

Conclusion
The study show that the discrete element simulation parameters of Chinese cabbage seeds model and calibration are reliable, which can provide reference for the discrete element simulation of Chinese cabbage seeds.
Effects of supplemental oxygen on systemic and cerebral hemodynamics in experimental hypovolemia: Protocol for a randomized, double blinded crossover study
Authors: Lindvåg Lie Sole , Hisdal Jonny , Rehn Marius , Høiseth Lars Øivind 
Published: June 2022

Supplemental oxygen is widely administered in trauma patients, often leading to hyperoxia. However, the clinical evidence for providing supplemental oxygen in all trauma patients is scarce, and hyperoxia has been found to increase mortality in some patient populations. Hypovolemia is a common finding in trauma patients, which affects many hemodynamic parameters, but little is known about how supplemental oxygen affects systemic and cerebral hemodynamics during hypovolemia. We therefore plan to conduct an experimental, randomized, double blinded crossover study to investigate the effect of 100% oxygen compared to room air delivered by a face mask with reservoir on systemic and cerebral hemodynamics during simulated hypovolemia in the lower body negative pressure model in 15 healthy volunteers. We will measure cardiac output, stroke volume, blood pressure, middle cerebral artery velocity and tolerance to hypovolemia continuously in all subjects at two visits to investigate whether oxygen affects the cardiovascular response to simulated hypovolemia. The effect of oxygen on the outcome variables will be analyzed with mixed linear regression.
Trial registration: The study is registered in the European Union Drug Regulating Authorities Clinical Trials Database (EudraCT, registration number 2021-003238-35).
Menstrual cycle changes and mental health states of women hospitalized due to COVID-19
Authors: Muharam R. , Agiananda Feranindhya , Budiman Yuri Fitri , Harahap Juliana Sari , Prabowo Kevin Ardito , Azyati Mazaya , Putri Yuannita Ika , Pratama Gita , Sumapraja Kanadi 
Published: June 2022

Purpose
Many studies have evaluated the impact of the COVID-19 pandemic on women’s mental health and menstrual changes. However, most of these studies only included nonhospitalized COVID-19 patients, while information on hospitalized women is very limited. Thus, this study aimed to examine the mental health status and menstrual changes in hospitalized female COVID-19 patients.

Methods
A survey was administered to female COVID-19 patients in the isolation ward of a national referral hospital in Indonesia between January and August 2021, and the women were followed up 3 months after discharge. The survey evaluated menstrual patterns and mental health using the Self Reporting Questionnaire-29 (SRQ-29).

Results
The study enrolled 158 female patients. There was an increase in patients who had a cycle length of > 32 or < 24 days, and significant increases in menstrual irregularity and heavy menstrual bleeding were noted. Overall, 37.3% of the patients reported a change in menstrual pattern after infection with COVID-19. Based on SRQ-29 scores, 32.3% of the women had neurotic symptoms, 12.7% had psychotic symptoms, and 38.0% had symptoms of posttraumatic stress disorder. Patients with symptoms of mental health disorders were twice as likely to report a menstrual change (OR 2.17, 95% CI 1.12–4.22; p = 0.021).

Conclusion
Menstrual changes and increased symptoms of mental health disorders occur in hospitalized female COVID-19 patients. The length of isolation was the key factor affecting overall menstrual changes and mental health in hospitalized female COVID-19 patients.
Study of Oligohydramnios and Perinatal Outcome in Term Pregnancy
Authors: Naseema Beevi  , Sona Venugopal  , Smitha Sreenivas  , Shaheem  
Published: June 2022

BACKGROUND
Oligohydramnios is associated with an increased risk of adverse pregnancy outcomes. The perinatal mortality rate in oligohydramnios is high. Oligohydramnios is also associated with fetal heart conduction abnormalities, meconium staining of the amniotic fluid, umbilical cord compression, lower Apgar scores, poor tolerance of labour and fetal acidosis. We wanted to assess the perinatal outcome in term pregnancies complicated with oligohydramnios in this study.
METHODS
A prospective cohort study was conducted among 200 cases of pregnant women with singleton term pregnancy with intact membranes and AFI < 5cm admitted from January 2019 to June 2020 in the Department of Obstetrics and Gynaecology, Government Medical College, Kozhikode. Antenatal patients with oligohydramnios confirmed by USG were induced within 24 hrs based on the Bishops score. History and examination findings were recorded in a predesigned proforma. Mode of delivery and APGAR scores were also noted. Neonatal complications and the need for ICU admission were studied up until their NICU admission or hospital stay.
Statistical Analysis: Statistical tests of association using SPSS (version 20.0) were employed at the level of significance of 5 %.
RESULTS
The majority of patients in this study were primigravida (60.5 %) and belonged to the age group 20-29 yrs (73.5 %). There was a higher rate of induction (67.5 %) in oligohydramnios patients. Around 26 % had meconium-stained amniotic fluid. The rate of caesarean section was found to be 22.5 % and that of instrumental delivery was 3.5 %. Oligohydramnios was associated with a higher rate of NICU admission (27.5 %). The most common complications noted were jaundice (9.8 %), birth asphyxia (4.9 %), meconium aspiration syndrome (3.4 %) and respiratory distress syndrome (1 %). Only 1 case of neonatal mortality was seen in this study.
CONCLUSIONS
Oligohydramnios adversely affects the maternal and perinatal outcome. It is associated with higher rates of induction, caesarean section, meconium-stained amniotic fluid, low APGAR scores, fetal distress and perinatal morbidity and mortality. However, the outcome can be improved by good antepartum and intrapartum monitoring and neonatal care.
A Study of Pregnancy in a Non-Communicating Rudimentary Horn of the Uterus
Authors: Dhruva Somashekhar Patil  , Manisha Manish Laddad  , Somashekhar Veerangouda Patil  
Published: June 2022

BACKGROUND
Pregnancy in a non-communicating horn of the uterus is a very rare entity. Incidentally, we had 11 cases in the last 6 years presenting in various ways. In literature, cases presented on pregnancy in a non-communicating horn are not many. Hence we are analysing our cases. The objectives of our study were to diagnose and manage such cases at the earliest and sharing our experience to help for its early diagnosis and further management.
METHODS
Records of women diagnosed with ectopic pregnancy in the rudimentary horn, during the last 6 years, were reviewed for their diagnostic difficulties and the associated morbidity.
RESULTS
Cases diagnosed before laparotomy were 3, and cases diagnosed after laparotomy were 8. Amongst 8 cases, 2 were intact and the other 6 had already ruptured. Laparotomy with excision of rudimentary horn and salpingectomy was done in all cases.
CONCLUSIONS
Suspicion is the main tool for diagnosis. Its suspicion and clinical finding along with imaging technology are very important for its early diagnosis and management.
Assessment of Knowledge of Emergency Management of Ocular Trauma in a Tertiary Care Hospital
Authors: Angela Edith  , Nitin Batra  , Rohan Kapoor  
Published: June 2022

BACKGROUND
Ocular trauma is a major cause of preventable monocular blindness and visual impairment worldwide. Thorough knowledge of comprehensive management of all types of ocular trauma is of utmost importance in the visual prognosis of such patients. Nurses are an integral part of emergency care. The objectives of this study were to assess the knowledge of emergency management of ocular trauma among the nursing staff and final year B.Sc. nursing students at a tertiary care hospital in northern India and suggest methods to enhance the knowledge if required.
METHODS
This prospective questionnaire-based study was conducted in the Department of Ophthalmology, at a tertiary care hospital in northern India to assess the nursing staff and final year B.Sc. nursing students about their knowledge of emergency management of ocular trauma. A total of 82 participants were randomly selected from the nursing staff as well as the B.Sc. final year nursing students and were asked to answer a questionnaire, based on their knowledge of the emergency management of ocular trauma. Data recorded was analysed using SPSS version 26.
RESULTS
The maximum score was 30 for answering the questions in the questionnaire. The mean score was found to be 23 among the nursing staff and a mean score of 21 among nursing students. A better overall score was noted among subjects who had experience working in Ophthalmology and Emergency Care.
CONCLUSIONS
It was found that there was a significant relationship between knowledge about emergency management of ocular trauma and variables like gender and work experience in the Department of Ophthalmology and Emergency Care. However, there was no significant association between knowledge of management of ocular trauma and the total number of working years. Knowledge regarding concepts about chemical injury was found to be low in all groups. Training and updating of knowledge on all aspects of ocular trauma must be done with an emphasis on emergency management during their posting in the Department of Ophthalmology and Emergency Care.