bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse reaction signals mining and hemorrhagic signals comparison of ticagrelor and clopidogrel: A pharmacovigilance study based on FAERS
Authors: Tang Shu , Wu Zhanshen , Xu Liqing , Wen Qiang , Zhang Xiaojian 
Published: October 2022

Background: Ticagrelor and clopidogrel are commonly used antiplatelet agents, and we conducted a pharmacovigilance analysis using the Food and Drug Administration Adverse Event Reporting System (FAERS) to provide a reference for safe and reasonable clinical use.Methods: Data were collected in FAERS from 2012 Q1 to 2022 Q2 for data cleaning. We used system organ classes (SOCs) and prefer terms (PTs) from the Medical Dictionary of Regulatory Activity (MedDRA version 25.1). Adverse event reports were retrieved at the PT level. Adverse reaction (ADR) signals of ticagrelor and clopidogrel were mined by calculating reporting odds ratios (ROR), proportional reporting ratios (PRR), information component (IC) and empirical Bayesian geometric mean (EBGM). After that, further analysis of the hemorrhagic signals and their clinical information were performed.Results: The number of ADR reports where the primary suspect (PS) drugs were 15,133 for ticagrelor and 23,860 for clopidogrel. Significant ADR signals were identified by the SOC analysis for ticagrelor including cardiac disorders (ROR 4.87, PRR 4.46), respiratory disorders (ROR 2.45, PRR 2.28), and vascular disorders (ROR 2.22, PRR 2.16). Clopidogrel included blood disorders (ROR 2.86, PRR 2.77), vascular disorders (ROR 2.71, PRR 2.61), and cardiac disorders (ROR 2.29, PRR 2.22). At the PT level, the more frequent ADR signals for ticagrelor were dyspnoea, contusion, and haemorrhage, while clopidogrel were gastrointestinal haemorrhage, anaemia, and drug interaction. The hemorrhagic signals of both were mainly focused on the SOC level of gastrointestinal disorders, injury disorders and vascular disorders and nervous system disorders. The death and life-threatening rate of ticagrelor was 7.76 percentage higher than that of clopidogrel.Conclusion: Clinicians need to pay attention to not only common ADRs but also be alert to new ADR signals when choosing to use ticagrelor and clopidogrel. This study provides a reference for the reasonable and safe clinical use of ticagrelor and clopidogrel.
Efficacy and safety of eight types Salvia miltiorrhiza injections in the treatment of unstable angina pectoris: A network meta-analysis
Authors: Li Mingxuan , Li Hongdian , Liu Hongxu , Lai Xiaolei , Xing Wenlong 
Published: October 2022

Background:Salvia miltiorrhiza Bunge. [Lamiaceae, danshen] injection classes (SMIC) is widely used in the treatment of unstable angina (UA). However, it is uncertain which SMIC is more effective in terms of UA efficacy. The purpose of this Network Meta-analysis (NMA) was to compare the treatment effects of various SMIC to determine the best SMIC for the treatment of UA.Methods: The China National Knowledge Infrastructure (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), Chinese Biomedical Literature Database (CBM), PubMed, Web of Science, and Cochrane Library databases were searched to screen randomized controlled trials (RCTs) of SMIC for UA. The search time frame was all from the establishment of the database to May 2022. RevMan 5.3 and Stata 14.0 software were used for NMA.Results: A total of 148 studies including 14,979 patients, including 7,584 cases in the experimental group and 7,395 cases in the control group were included, and eight SMIC were extracted, namely:Danshen injection, Fufang Danshen injection, Guanxinning injection, Danshenchuanxiongqin injection, Danhong injection, Danshentong IIA Huangsuanna injection, Shenxiong Putaotang injection, and Danshenduofensuanyan injection. The results of NMA showed that, in terms of total effective rate, Shenxiong Putaotang injection and Danshenchuanxiongqin injection have the advantage; In terms of ECG efficiency, Danshentong IIA Huangsuanna injection and Danshen injection have an advantage; Danshenchuanxiongqin injection and Danshenduofensuanyan injection were more effective than other SMIC in improving angina pectoris attacks; Shenxiong Putaotang injection has an advantage in improving hs-CRP; Shenxiong Putaotang injection and Danshentong IIA Huangsuanna injection have advantages in improving TC and TG, respectively.Conclusion: The eight SMIC included in the current study were effective in treating UA, Shenxiong Putaotang injection and Danshentong IIA Huangsuanna injection were both superior in improving all outcome indicators. However, there is still a need for larger samples and high-quality randomized controlled trials for more refined comparisons of various SMIC.Systematic Review Registration: [PROSPERO], identifier [CRD42022350872]
Dupilumab efficacy and safety in patients with moderate to severe asthma: A systematic review and meta-analysis
Authors: Zaazouee Mohamed Sayed , Alwarraqi Asmaa Gomaa , Mohammed Yasmine Adel , Badheeb Mohamed A. , Farhat Abdullah Mohamed , Eleyan Mohammed , Morad Afnan , Zeid Marwa Abdel-Aziz , Mohamed Aya Shaban , AbuEl-Enien Hazem , Abdelalim Ahmed , Elsnhory Ahmed Bostamy , Hrizat Yasmin S. M. , Altahir Nagat Taha , Atef Doaa , Elshanbary Alaa Ahmed , Alsharif Khalaf F. , Alzahrani Khalid J. , Algahtani Mohammad , Theyab Abdulrahman , Hawsawi Yousef M. , Aldarmahi Ahmed A. , Abdel-Daim Mohamed M. 
Published: October 2022

Background: Dupilumab is a human monoclonal antibody directed against the alpha subunit of the interleukin-4 receptor and inhibits the signaling of IL-4 and IL-13. It is approved for treating asthma and other type-2 inflammatory diseases. There is a conflict in the literature regarding the safety and efficacy of dupilumab. Thus, we aimed to assess the safety and efficacy of dupilumab in patients with moderate to severe asthma.Methods: Six databases (PubMed, Embase, Scopus, Web of Science, Cochrane library, and clinicaltrials.gov registry) were searched until January 2022. We included randomized controlled trials that compared dupilumab with the placebo in moderate to severe asthma patients. We extracted the data at 12 and 24 weeks and analyzed them using review manager 5.4.Findings: Thirteen trials were included. Dupilumab significantly improved the forced expiratory volume in 1 s, asthma control questionnaire score, the fraction of exhaled nitric oxide level, and immunoglobulin E level at 12 and 24 weeks (p &lt; 0.05). However, it was associated with increased blood eosinophils at 12 and 24 weeks. Dupilumab was generally a safe agent for asthmatic patients. It showed no significant difference compared with the placebo regarding most adverse events.Conclusion: Dupilumab improves pulmonary function and reduces local and systemic inflammatory markers with minimal adverse events in patients with moderate to severe asthma.
The edge-coupler of fiber-to-chip with ultra-low coupling loss based on double-layer silicon waveguides
Authors: Ma Xiaoyue , Hu Heming , Liu Shiping , Dong Runyu , Fang Qing , Chen Hua 
Published: October 2022

The edge-coupler of fiber-to-chip with ultra-low coupling loss is demonstrated on SOI platform. The edge-coupler is consisted of the cantilevered SiO2 waveguide, the amorphous silicon (α-Si) nano taper and the crystal silicon (c-Si) nano tapers. The thin α-Si layer is deposited on the c-Si layer to improve the pattern matching with fiber. The optical input signal from the optical fiber is launched into the suspended SiO2 waveguide, then coupled into the α-Si nano taper at the center of the SiO2 waveguide, and finally coupled into the c-Si nano taper. We characterized the cantilevered edge-coupler using cleaved single-mode optical fiber with a mode field diameter of 10.5 μm. The measured coupling loss is as low as -1.7 dB per facet for TE mode without index matching liquid at 1550 nm. The 1 dB bandwidth is more than 100 nm with 1 dB alignment tolerances of ±2.0 μm in both horizontal and vertical directions. Besides, potential hybrid optical integration could also be allowed with this results in the future.
High scintillation yield and fast response to alpha particles from thin perovskite films deposited by pulsed laser deposition
Authors: Caricato Anna Paola , Moretto Sandra , Guascito Maria Rachele , Quarta Gianluca , Mazzeo Marco , Favaro Matteo , Rizwan Aziz Muhammad , Provenzano Chiara , Marra Marcella , Cesaria Maura , Polo Matteo , Delgado Jessica , Pino Felix , Martino Maurizio , Calcagnile Lucio , Quaranta Alberto 
Published: October 2022

Although the field of solar cells is the most popular application of perovskite materials, their use in radiation detection applications is emerging. The success of perovskites as radiation detectors rests partly on the same material properties that have led to successful optoelectronics applications, meaning that other specific properties, like large stopping power, high mobility lifetime product, fast response, and large bulk resistance, play a role. In this respect, inorganic perovskites are attracting a lot of attention as scintillator materials with performances sensitive to material shape (single crystals, nanocrystals, and thin films) and growth methods. In this study, we report on the morphological, structural, and optical response of thin CsPbBr3-based perovskite films, deposited by Pulsed Laser Deposition (PLD) and post-growth annealed at 350°C in air, following excitation by different particle sources. The annealing treatment resulted in a prompt structural refinement, grain growth, and oxygen bonding to the Pb phase together with an enrichment of the surface in chemo-adsorbed oxygen probably due to Cs–O interactions, as evidenced by X-ray photoelectron spectroscopy. The film behavior under 2 MeV H+ ion beam irradiation at different fluences was analyzed together with its scintillation properties following an interaction with α particles from an Am-241 radioactive source demonstrating a very fast response for an inorganic material (∼5ns) and a photoelectron yield of about ∼47% with respect to a commercial CsI:Tl scintillator.
Comprehensive training load monitoring with biomarkers, performance testing, local positioning data, and questionnaires - first results from elite youth soccer
Authors: Haller Nils , Blumkaitis Julia C. , Strepp Tilmann , Schmuttermair Anna , Aglas Lorenz , Simon Perikles , Neuberger Elmo , Kranzinger Christina , Kranzinger Stefan , O’Brien James , Ergoth Bernd , Raffetseder Stefan , Fail Christian , Düring Manfred , Stöggl Thomas 
Published: October 2022

Load management, i.e., prescribing, monitoring, and adjusting training load, is primarily aimed at preventing injury and maximizing performance. The search for objective monitoring tools to assess the external and internal load of athletes is of great interest for sports science research. In this 4-week pilot study, we assessed the feasibility and acceptance of an extensive monitoring approach using biomarkers, neuromuscular performance, and questionnaires in an elite youth soccer setting. Eight male players (mean ± SD: age: 17.0 ± 0.6 years, weight: 69.6 ± 8.2 kg, height: 177 ± 7 cm, VO2max: 62.2 ± 3.8 ml/min/kg) were monitored with a local positioning system (e.g., distance covered, sprints), biomarkers (cell-free DNA, creatine kinase), questionnaires, neuromuscular performance testing (counter-movement jump) and further strength testing (Nordic hamstring exercise, hip abduction and adduction). Feasibility was high with no substantial impact on the training routine and no adverse events such as injuries during monitoring. Adherence to the performance tests was high, but adherence to the daily questionnaires was low, and decreased across the study period. Occasional significant correlations were observed between questionnaire scores and training load data, as well as between questionnaire scores and neuromuscular performance. However, due to the small sample size, these findings should be treated with caution. These preliminary results highlight the feasibility of the approach in elite soccer, but also indicate that modifications are needed in further large-scale studies, particularly in relation to the length of the questionnaire.
A multi-center study on the association between serum magnesium levels and allostatic load in hemodialysis patients
Authors: Zhang Yingxin , Yang Zhengling , Yang Huan , Li Xiuyong , Liu Zhi , Bai Youwei , Qian Guangrong , Wu Han , Li Ji , Guo Yuwen , Yang Shanfei , Chen Lei , Yang Jian , Han Jiuhuai , Ma Shengyin , Yang Jing , Yu Linfei , Shui Runzhi , Jin Xiping , Wang Hongyu , Zhang Fan , Chen Tianhao , Li Xinke , Zong Xiaoying , Liu Li , Fan Jihui , Wang Wei , Zhang Yong , Shi Guangcai , Wang Deguang , Tao Shuman 
Published: October 2022

Objective: Serum magnesium (Mg2+) levels are associated with insulin resistance, hypertension, lipid abnormalities, and inflammation. However, limited studies have indicated the relationship between Mg2+ and multiple system indexes. The purpose of this study was to investigate the association between Mg2+ and allostatic load (AL) in hemodialysis patients.Methods: A cross-sectional survey was conducted on hemodialysis patients from different centers in Anhui Province, China, between January and December 2020. A total of 3,025 hemodialysis patients were recruited. Their clinical data were measured before hemodialysis. Information was collected by an online self-reported questionnaire and medical record. Serum Mg2+ was divided into three groups by tertiles. A score of AL greater than or equal to 3 was defined as high AL. A binary logistic regression model was applied to examine the relationship between serum Mg2+ and AL.Results: A total of 1,222 patients undergoing hemodialysis were included, 60% of whom were males (733/1,222). The mean (standard deviation) age of patients was 55.90 (12.75). The median level of serum Mg2+ was 1.22 mmol/L. The rate of high AL levels was 23.4%. Serum Mg2+ was negatively correlated with body mass index, fasting blood glucose (Glu), and C-reactive protein and positively correlated with high-density lipoprotein, low-density lipoprotein, total cholesterol, diastolic blood pressure (DBP), and serum phosphorus. After adjusting for gender, anxiety, diabetes, family residence, lipid-lowering agents, antihypertensive medications, albumin, and Glu, the binary logistic regression model showed that patients with lower levels of serum Mg2+ were more likely have high AL (OR for the T1 group of serum Mg2+:1.945, 95% CI: 1.365–2.773, and OR for the T2 group of serum Mg2+:1.556, 95% CI: 1.099–2.201).Conclusion: Our data support the hypothesis that higher serum Mg2+ concentrations may contribute to lower health risk in hemodialysis populations. Further randomized controlled trials and cohort studies are warranted to verify whether Mg2+ supplementation could be part of routine examinations in hemodialysis populations.
Examine the Moderating Role of Teacher’s Self-Efficacy in the Relationship Between the Job Satisfaction and Professional Learning Community in China
Authors: Li Qiang-tian 
Published: October 2022

AbstractPurposeThe study aimed in examining the impact of the professional learning community, and teachers’ self-efficacy on the job satisfaction of teachers. Additionally, the study has also examined the moderating role of teachers’ self-efficacy in the relationship between the professional learning community (PLC) and job satisfaction.MethodThe SEM-PLS is employed for the data analysis. The response rate of the study is 50%. The study is carried out on the primary teachers in China.ResultsThree research questions were developed in the current study. The questions were related to the job satisfaction level of PE teachers, which was far beyond the level of satisfaction. As a result, teachers of PE classes had low performance. It was found by the study that professional learning community, job satisfaction of teachers, and self-efficacy are linked with each other. However, the results are inconclusive because of the limitation of the sample.ImplicationsThe study has several implications among researchers, practitioners, and teachers.SignificanceThe study is among the few earlier studies on the issues related to Job Satisfaction and the professional learning community in China.Originality/ValueThe study has highlighted an important issue related to the Job Satisfaction and professional learning community in China.
Is maternal negative affectivity related to psychosocial behavior of preterm and term-born toddlers through mother–child interaction?
Authors: Krijnen L. J. G. , Verhoeven M. , van Baar A. L. 
Published: October 2022

IntroductionChildren born moderately to late preterm (MLP) are more prone to psychosocial difficulties than their term-born counterparts. Maternal negative affectivity (NA)–a relatively stable personality trait characterized by the tendency to experience negative thoughts, feelings and emotions–has been related to more psychosocial problems in their offspring, and to a lower quality of mother–child interactions. As MLP children seem more sensitive to their early caregiving environment, they might be more affected by maternal NA and interaction style than their term-born peers. The current study investigated whether maternal NA predicted child’s psychosocial outcomes through quality of mother–child interaction, and if these associations differed between MLP and term-born children.MethodsThe sample consisted of 108 MLP and 92 term-born children and their mothers. At 18 months corrected age, maternal NA was measured using a self-report questionnaire and mother–child interaction was observed during two structured tasks. Five subscales of mother–child interaction were assessed: negative interaction, reciprocal engagement, emotional support, maternal stimulation and mother-led interaction. At 24 months corrected age, social–emotional difficulties, internalizing, and externalizing problems were assessed using mother-report.ResultsFor MLP children, maternal NA directly, positively, predicted social–emotional difficulties (b = 0.57) and internalizing problems (b = 0.45), but no mediation effect of mother–child interaction was found. For term-born children, no direct effect but a mediation effect of mother-led interaction was found. Higher levels of maternal NA predicted less mother-led interaction which in turn predicted more problems. Birth status did not moderate any of the relationships, showing that the differences in patterns of effects found within the MLP and term-born group did not reach statistical significance.DiscussionMaternal NA was found to be a risk factor for psychosocial outcomes in toddlers, either directly for MLP children or indirectly through mother-led interaction for term-born children. These findings suggest that the process through which maternal NA affects psychosocial outcomes may be different for MLP and term-born children. However, as the examined moderation effects of birth status did not reach statistical significance, more research using larger sample sizes is needed to study mother–child interaction in greater detail.
Unveiling mechanisms of change in digital interventions for depression: Study protocol for a systematic review and individual participant data meta-analysis
Authors: Domhardt Matthias , Grund Simon , Mayer Axel , Büscher Rebekka , Ebert David D. , Sander Lasse B. , Karyotaki Eirini , Cuijpers Pim , Baumeister Harald 
Published: October 2022

IntroductionThe efficacy and effectiveness of digital interventions for depression are both well-established. However, precise effect size estimates for mediators transmitting the effects of digital interventions are not available; and integrative insights on the specific mechanisms of change in internet- and mobile-based interventions (IMIs)—as related to key features like delivery type, accompanying support and theoretical foundation—are largely pending.ObjectiveWe will conduct a systematic review and individual participant data meta-analysis (IPD-MA) evaluating the mediators associated with therapeutic change in various IMIs for depression in adults.MethodsWe will use three electronic databases (i.e., Embase, Medline/PubMed, PsycINFO) as well as an already established database of IPD to identify relevant published and unpublished studies. We will include (1) randomized controlled trials that examine (2) mediators of (3) guided and unguided (4) IMIs with (5) various theoretical orientations for (6) adults with (7) clinically relevant symptoms of depression (8) compared to an active or passive control condition (9) with depression symptom severity as primary outcome. Study selection, data extraction, as well as quality and risk of bias (RoB) assessment will be done independently by two reviewers. Corresponding authors of eligible primary studies will be invited to share their IPD for this meta-analytic study. In a 1-stage IPD-MA, mediation analyses (e.g., on potential mediators like self-efficacy, emotion regulation or problem solving) will be performed using a multilevel structural equation modeling approach within a random-effects framework. Indirect effects will be estimated, with multiple imputation for missing data; the overall model fit will be evaluated and statistical heterogeneity will be assessed. Furthermore, we will investigate if indirect effects are moderated by different variables on participant- (e.g., age, sex/gender, symptom severity), study- (e.g., quality, studies evaluating the temporal ordering of changes in mediators and outcomes), and intervention-level (e.g., theoretical foundation, delivery type, guidance).DiscussionThis systematic review and IPD-MA will generate comprehensive information on the differential strength of mediators and associated therapeutic processes in digital interventions for depression. The findings might contribute to the empirically-informed advancement of psychotherapeutic interventions, leading to more effective interventions and improved treatment outcomes in digital mental health. Besides, with our novel approach to mediation analyses with IPD-MA, we might also add to a methodological progression of evidence-synthesis in psychotherapy process research.Study registration with Open Science Framework (OSF)https://osf.io/md7pq/.