bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concurrent anxiety in patients with major depression and cerebral serotonin 4 receptor binding. A NeuroPharm-1 study
Authors: Köhler-Forsberg Kristin , Ozenne Brice , Larsen Søren V. , Poulsen Asbjørn S. , Landman Elizabeth B. , Dam Vibeke H. , Ip Cheng-Teng , Jørgensen Anders , Svarer Claus , Knudsen Gitte M. , Frokjaer Vibe G. , Jørgensen Martin B. 
Published: July 2022

AbstractConcurrent anxiety is frequent in major depressive disorder and a shared pathophysiological mechanism between anxiety and other depressive symptoms is plausible. The serotonin 4 receptor (5-HT4R) has been implicated in both depression and anxiety. This is the first study to investigate the association between the cerebral 5-HT4R binding and anxiety in patients with depression before and after antidepressant treatment and the association to treatment response. Ninety-one drug-free patients with depression were positron emission tomography scanned with the 5-HT4R ligand [11C]-SB207145. Depression severity and concurrent anxiety was measured at baseline and throughout 8 weeks of antidepressant treatment. Anxiety measures included four domains: anxiety/somatization factor score; Generalized Anxiety Disorder 10-items (GAD-10) score; anxiety/somatization factor score ≥7 (anxious depression) and syndromal anxious depression. Forty patients were rescanned at week 8. At baseline, we found a negative association between global 5-HT4R binding and both GAD-10 score (p < 0.01) and anxiety/somatization factor score (p = 0.06). Further, remitters had a higher baseline anxiety/somatization factor score compared with non-responders (p = 0.04). At rescan, patients with syndromal anxious depression had a greater change in binding relative to patients with non-syndromal depression (p = 0.04). Concurrent anxiety in patients with depression measured by GAD-10 score and anxiety/somatization factor score is negatively associated with cerebral 5-HT4R binding. A lower binding may represent a subtype with reduced natural resilience against anxiety in a depressed state, and concurrent anxiety may influence the effect on the 5-HT4R from serotonergic antidepressants. The 5-HT4R is a promising neuroreceptor for further understanding the underpinnings of concurrent anxiety in patients with depression.
Psychiatric symptoms are not associated with circulating CRP concentrations after controlling for medical, social, and demographic factors
Authors: Figueroa-Hall Leandra K. , Xu Bohan , Kuplicki Rayus , Ford Bart N. , Burrows Kaiping , Teague T. Kent , Sen Sandip , Yeh Hung-Wen , Irwin Michael R. , Savitz Jonathan , Paulus Martin P. 
Published: July 2022

AbstractElevated serum concentrations (>3 mg/L) of the acute-phase protein, C-reactive protein (CRP), is used as a clinical marker of inflammation and is reported to be a strong risk factor for cardiovascular disease. In psychiatric populations, CRP concentration is reported to be higher in depressed versus healthy individuals. Positive associations between CRP and depression have been established in both clinical and community samples, but effect sizes are attenuated after controlling for confounding variables. Similarly, emerging research has begun to draw a link between inflammation, symptoms of anxiety, and substance abuse. Given the high level of comorbid anxiety and substance use disorders in many depressed populations, this study examined whether depression (Patient Health Questionnaire 9 [PHQ-9]) and substance use-related (Drug Abuse Screening Test [DAST]) symptoms were associated with CRP concentrations in the blood after adjusting for relevant medical, social, and demographic covariates in a large sample undergoing screening for several transdiagnostic psychiatric research studies. A total of 1,724 participants were analyzed for association of CRP with variables using multivariate linear regression. An unadjusted model with no covariates showed that PHQ-9 was significantly associated with CRP in All (β = 0.125), Female (β = 0.091), and Male (β = 0.154) participants, but DAST was significantly associated with CRP in males only (β = 0.120). For the adjusted model, in both males and females, mood-stabilizer treatment (β = 0.630), opioid medication (β = 0.360), body mass index (β = 0.244), percent body fat (β = 0.289), nicotine use (β = 0.063), and self-reported sleep disturbance (β = 0.061) were significantly associated with increased CRP concentrations. In females, oral contraceptive use (β = 0.576), and waist-to-hip ratio (β = 0.086), and in males, non-steroidal anti-inflammatory drug use (β = 0.367) were also associated with increased CRP concentrations. There was no significant association between CRP and individual depressive, anxiety, or substance use-related symptoms when covariates were included in the regression models. These results suggest that associations between circulating CRP and the severity of psychiatric symptoms are dependent on the type of covariates controlled for in statistical analyses.
A scoring system for AML patients aged 70 years or older, eligible for intensive chemotherapy: a study based on a large European data set using the DATAML, SAL, and PETHEMA registries
Authors: Bérard Emilie , Röllig Christoph , Bertoli Sarah , Pigneux Arnaud , Tavitian Suzanne , Kramer Michael , Serve Hubert , Bornhäuser Martin , Platzbecker Uwe , Müller-Tidow Carsten , Baldus Claudia D. , Martínez-Cuadrón David , Serrano Josefina , Martínez-Sánchez Pilar , Arbolí Eduardo Rodríguez , Gil Cristina , Bergua Juan , Bernal Teresa , de la Fuente Burguera Adolfo , Delabesse Eric , Bidet Audrey , Dumas Pierre-Yves , Montesinos Pau , Récher Christian 
Published: July 2022

AbstractIn a context of therapeutic revolution in older adults with AML, it is becoming increasingly important to select patients for the various treatment options by taking account of short-term efficacy and toxicity as well as long-term survival. Here, the data from three European registries for 1,199 AML patients aged 70 years or older treated with intensive chemotherapy were used to develop a prognostic scoring system. The median follow-up was 50.8 months. In the training set of 636 patients, age, performance status, secondary AML, leukocytosis, and cytogenetics, as well as NPM1 mutations (without FLT3-ITD), were all significantly associated with overall survival, albeit not to the same degree. These factors were used to develop a score that predicts long-term overall survival. Three risk-groups were identified: a lower, intermediate and higher-risk score with predicted 5-year overall survival (OS) probabilities of ≥12% (n = 283, 51%; median OS = 18 months), 3–12% (n = 226, 41%; median OS = 9 months) and <3% (n = 47, 8%; median OS = 3 months), respectively. This scoring system was also significantly associated with complete remission, early death and relapse-free survival; performed similarly in the external validation cohort (n = 563) and showed a lower false-positive rate than previously published scores. The European Scoring System ≥70, easy for routine calculation, predicts long-term survival in older AML patients considered for intensive chemotherapy.
A unique Smith-Magenis patient with a de novo intragenic deletion on the maternally inherited overexpressed RAI1 allele
Authors: Sironi Alessandra , Bestetti Ilaria , Masciadri Maura , Tumiatti Francesca , Crippa Milena , Pantaleoni Chiara , Russo Silvia , D’Arrigo Stefano , Milani Donatella , Larizza Lidia , Finelli Palma 
Published: July 2022

AbstractRAI1 is a dosage-sensitive gene whose decreased or increased expression by recurrent and non-recurrent 17p11.2 deletions or duplications causes Smith-Magenis (SMS) or Potocki-Lupski syndromes (PTLS), respectively. Here we report on a 21-year-old female patient showing SMS phenotype who was found to carry a 3.4 kb de novo intragenic RAI1 deletion. Interestingly, a significant increase in RAI1 transcript levels was identified in the patient’s, brother’s and mother’s peripheral blood cells. Allele-specific dosage analysis revealed that the patient’s maternally inherited overexpressed RAI1 allele harbors the intragenic deletion, confirming the SMS diagnosis due to the presence of a single wild-type RAI1 functional allele. The mother and brother do not present any PTLS neurologic/behavioral clinical features. Extensive sequencing of RAI1 promoter and predicted regulatory regions showed no potential causative variants accounting for gene overexpression. However, the mother and both children share a novel private missense variant in RAI1 exon 3, currently classified as a VUS (uncertain significance), though predicted by two bioinformatic tools to disrupt the binding site of one specific transcription factor. The reported familial case, the second showing RAI1 overexpression in the absence of RAI1 duplication, may help to understand the regulation of RAI1 dosage sensitivity although its phenotypic effect remains to be determined.
Atomic-resolution structures from polycrystalline covalent organic frameworks with enhanced cryo-cRED
Authors: Li Jian , Lin Cong , Ma Tianqiong , Sun Junliang 
Published: July 2022

AbstractThe pursuit of atomic precision structure of porous covalent organic frameworks (COFs) is the key to understanding the relationship between structures and properties, and further developing new materials with superior performance. Yet, a challenge of how to determine their atomic structures has always existed since the first COFs reported seventeen years ago. Here, we present a universal method for ab initio structure determination of polycrystalline three-dimensional (3D) COFs at atomic level using enhanced cryo-continuous rotation electron diffraction (cryo-cRED), which combines hierarchical cluster analysis with cryo-EM technique. The high-quality datasets possess not only up to 0.79-angstrom resolution but more than 90% completeness, leading to unambiguous solution and precise refinement with anisotropic temperature factors. With such a powerful method, the dynamic structures with flexible linkers, degree of interpenetration, position of functional groups, and arrangement of ordered guest molecules are successfully revealed with atomic precision in five 3D COFs, which are almost impossible to be obtained without atomic resolution structure solution. This study demonstrates a practicable strategy for determining the structures of polycrystalline COFs and other beam-sensitive materials and to help in the future discovery of novel materials on the other.
Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles
Authors: Li Jingchao , Luo Yu , Zeng Ziling , Cui Dong , Huang Jiaguo , Xu Chenjie , Li Liping , Pu Kanyi , Zhang Ruiping 
Published: July 2022

AbstractNanomedicine holds promise to enhance cancer immunotherapy; however, its potential to elicit highly specific anti-tumor immunity without compromising immune tolerance has yet to be fully unlocked. This study develops deep-tissue activatable cancer sono-immunotherapy based on the discovery of a semiconducting polymer that generates sonodynamic singlet oxygen (1O2) substantially higher than other sonosensitizers. Conjugation of two immunomodulators via 1O2-cleavable linkers onto this polymer affords semiconducting polymer immunomodulatory nanoparticles (SPINs) whose immunotherapeutic actions are largely inhibited. Under ultrasound irradiation, SPINs generate 1O2 not only to directly debulk tumors and reprogram tumor microenvironment to enhance tumor immunogenicity, but also to remotely release the immunomodulators specifically at tumor site. Such a precision sono-immunotherapy eliminates tumors and prevents relapse in pancreatic mouse tumor model. SPINs show effective antitumor efficacy even in a rabbit tumor model. Moreover, the sonodynamic activation of SPINs confines immunotherapeutic action primarily to tumors, reducing the sign of immune-related adverse events.
Relativistic Bohmian trajectories of photons via weak measurements
Authors: Foo Joshua , Asmodelle Estelle , Lund Austin P. , Ralph Timothy C. 
Published: July 2022

AbstractBohmian mechanics is a nonlocal hidden-variable interpretation of quantum theory which predicts that particles follow deterministic trajectories in spacetime. Historically, the study of Bohmian trajectories has mainly been restricted to nonrelativistic regimes due to the widely held belief that the theory is incompatible with special relativity. Here, we present an approach for constructing the relativistic Bohmian-type velocity field of single particles. The advantage of our proposal is that it is operational in nature, grounded in weak measurements of the particle’s momentum and energy. We apply our weak measurement formalism to obtain the relativistic spacetime trajectories of photons in a Michelson–Sagnac interferometer. The trajectories satisfy quantum-mechanical continuity and the relativistic velocity addition rule. We propose a modified Alcubierre metric which could give rise to these trajectories within the paradigm of general relativity.
Anisotropic magnon damping by zero-temperature quantum fluctuations in ferromagnetic CrGeTe3
Authors: Chen Lebing , Mao Chengjie , Chung Jae-Ho , Stone Matthew B. , Kolesnikov Alexander I. , Wang Xiaoping , Murai Naoki , Gao Bin , Delaire Olivier , Dai Pengcheng 
Published: July 2022

AbstractSpin and lattice are two fundamental degrees of freedom in a solid, and their fluctuations about the equilibrium values in a magnetic ordered crystalline lattice form quasiparticles termed magnons (spin waves) and phonons (lattice waves), respectively. In most materials with strong spin-lattice coupling (SLC), the interaction of spin and lattice induces energy gaps in the spin wave dispersion at the nominal intersections of magnon and phonon modes. Here we use neutron scattering to show that in the two-dimensional (2D) van der Waals honeycomb lattice ferromagnetic CrGeTe3, spin waves propagating within the 2D plane exhibit an anomalous dispersion, damping, and breakdown of quasiparticle conservation, while magnons along the c axis behave as expected for a local moment ferromagnet. These results indicate the presence of dynamical SLC arising from the zero-temperature quantum fluctuations in CrGeTe3, suggesting that the observed in-plane spin waves are mixed spin and lattice quasiparticles fundamentally different from pure magnons and phonons.
Enhancing fibre-optic distributed acoustic sensing capabilities with blind near-field array signal processing
Authors: Muñoz Felipe , Soto Marcelo A. 
Published: July 2022

AbstractDistributed acoustic sensors (DAS) can monitor mechanical vibrations along thousands independent locations using an optical fibre. The measured acoustic waveform highly varies along the sensing fibre due to the intrinsic uneven DAS longitudinal response and distortions originated during mechanical wave propagation. Here, we propose a fully blind method based on near-field acoustic array processing that considers the nonuniform response of DAS channels and can be used with any optical fibre positioning geometry having angular diversity. With no source and fibre location information, the method can reduce signal distortions and provide relevant signal-to-noise ratio enhancement through sparse beamforming spatial filtering. The method also allows the localisation of the two-dimensional spatial coordinates of acoustic sources, requiring no specific fibre installation design. The method offers distributed analysis capabilities of the entire acoustic field outside the sensing fibre, enabling DAS systems to characterise vibration sources placed in areas far from the optical fibre.
A randomized phase 3 trial of Gemcitabine or Nab-paclitaxel combined with cisPlatin as first-line treatment in patients with metastatic triple-negative breast cancer
Authors: Wang Biyun , Sun Tao , Zhao Yannan , Wang Shusen , Zhang Jian , Wang Zhonghua , Teng Yue-E , Cai Li , Yan Min , Wang Xiaojia , Jiang Zefei , Pan Yueyin , Luo Jianfeng , Shao Zhimin , Wu Jiong , Guo Xiaomao , Hu Xichun 
Published: July 2022

AbstractPlatinum is recommended in combination with gemcitabine in the treatment of metastatic triple-negative breast cancer (mTNBC). We conduct a randomized phase 3, controlled, open-label trial to compare nab-paclitaxel/cisplatin (AP) with gemcitabine/cisplatin (GP) in mTNBC patients (ClinicalTrials.gov NCT02546934). 254 patients with untreated mTNBC randomly receive AP (nab-paclitaxel 125 mg/m² on day 1, 8 and cisplatin 75 mg/m² on day 1) or GP (gemcitabine 1250 mg/m² on day 1, 8 and cisplatin 75 mg/m² on day 1) intravenously every 3 weeks until progression disease, intolerable toxicity or withdrawal of consent. The primary endpoint is progression-free survival (PFS); secondary endpoints are objective response rate (ORR), safety and overall survival (OS). The trial has met pre-specified endpoints. The median PFS is 9.8 months with AP as compared to 7.4 months with GP (stratified HR, 0.67; 95% CI, 0.50–0.88; P = 0.004). AP significantly increases ORR (81.1% vs. 56.3%, P < 0.001) and prolongs OS (stratified HR, 0.62; 95% CI, 0.44–0.90; P = 0.010) to GP. Of grade 3 or 4 adverse events, a significantly higher incidence of neuropathy in AP and thrombocytopenia in GP is noted. These findings warrant further assessment of adding novel agents to the nab-paclitaxel/platinum backbone due to its high potency for patients with mTNBC.
On the role of Al/Nb in the SCC of AFA stainless steels in supercritical CO2
Authors: Cong Shuo , Ma Zhaodandan , Liu Zhu , Duan Zhengang , Zhou Zhangjian , Zhang Lefu , Guo Xianglong 
Published: July 2022

AbstractSCC of a series of AFA stainless steels with different Al and Nb contents were studied in supercritical CO2 by SSRT. The results show that Nb element plays a precipitation strengthening on the mechanical properties, while it shows few effects on the corrosion properties. The surface oxide film of the Al-free material only consisted of amorphous Cr2O3 and Cr-rich spinel. With the addition of Al, the Al2O3 layers are formed and significantly decreases the element diffusion, thus inhibiting the initiation of SCC. Fe3O4 fills the interior of cracks of both Al-free and Al-containing materials. The Al2O3 layer is formed at the crack tip of Al-containing materials. Because the matrix grains are large, the protective Al2O3 layer can only be formed at the crack tip, which cannot completely hinder the outward diffusion of ions on the crack walls and its protective effect on the crack propagation is limited.
The control of waterborne pathogenic bacteria in fresh water using a biologically active filter
Authors: Steven Joshua A. C. , Thorn Robin M. S. , Robinson Gareth M. , Turner Dann , Lee Jack E. , Reynolds Darren M. 
Published: July 2022

AbstractThe aim of this study was to investigate the control of three species of bacteria commonly associated with biologically contaminated water, using biofiltration. In this study, a laboratory-scale biofilter system was used to investigate the control of Escherichia coli, Enterococcus faecalis, and Pseudomonas aeruginosa in fresh water. Simulated fresh water was inoculated with the test pathogens at a starting inocula of ~1000 CFU 100 mL−1 to challenge the biofilters. Biofilter systems operating within a recirculation configuration demonstrated significant reduction of E. coli (99%), E. faecalis (99%), and P. aeruginosa (92%) after 24 h. Conversely, all sterile control systems did not show any significant reduction in pathogens. Subsequent analysis of the biofilter media after circulation showed that 0% of E. coli was recovered from the biofilter, whereas 0.06% and 1.26% of E. faecalis and P. aeruginosa were recovered respectively. Further investigation demonstrated the reduction of E. coli and enterococci from an environmentally-derived surface water of 99.8% and 99.4% respectively. In conclusion, this work demonstrates that biofilter systems can be used to significantly reduce waterborne pathogenic bacteria within fresh water. The potential application of low-cost, energy efficient biofilter systems for the management of waterborne bacterial pathogens in water supplies is discussed.
Transatlantic spread of highly pathogenic avian influenza H5N1 by wild birds from Europe to North America in 2021
Authors: Caliendo V. , Lewis N. S. , Pohlmann A. , Baillie S. R. , Banyard A. C. , Beer M. , Brown I. H. , Fouchier R. A. M. , Hansen R. D. E. , Lameris T. K. , Lang A. S. , Laurendeau S. , Lung O. , Robertson G. , van der Jeugd H. , Alkie T. N. , Thorup K. , van Toor M. L. , Waldenström J. , Yason C. , Kuiken T. , Berhane Y. 
Published: July 2022

AbstractHighly pathogenic avian influenza (HPAI) viruses of the A/Goose/Guangdong/1/1996 lineage (GsGd), which threaten the health of poultry, wildlife and humans, are spreading across Asia, Europe, Africa and North America but are currently absent from South America and Oceania. In December 2021, H5N1 HPAI viruses were detected in poultry and a free-living gull in St. John’s, Newfoundland and Labrador, Canada. Our phylogenetic analysis showed that these viruses were most closely related to HPAI GsGd viruses circulating in northwestern Europe in spring 2021. Our analysis of wild bird migration suggested that these viruses may have been carried across the Atlantic via Iceland, Greenland/Arctic or pelagic routes. The here documented incursion of HPAI GsGd viruses into North America raises concern for further virus spread across the Americas by wild bird migration.
Impact of squid predation on juvenile fish survival
Authors: Takahashi Motomitsu , Sakamoto Tatsuya , Sassa Chiyuki , Yoda Mari 
Published: July 2022

AbstractPredation is a major source of mortality during the early life stages of marine fishes; however, few studies have demonstrated its impact—especially that of squid predation—on survival processes. Here, we examined the feeding habits and predation impacts of swordtip squid on a major prey fish, juveniles of jack mackerel, in the East China Sea. Otoliths of the juveniles extracted from the squid stomach were used to reconstruct the age–length relationship and the growth trajectory of the consumed juveniles, and they were compared to those of juveniles collected with a net using a newly developed statistical framework. The juveniles consumed by squid had significantly shorter body lengths and smaller body sizes during the late larval and early juvenile stages than the netted juveniles, suggesting that smaller juveniles with slower growth rates have a higher probability to be selected. The body mass ratio of the predator squid to prey juveniles (predator–prey mass ratio, PPMR) ranged from 7 to 700, which was remarkably lower than the PPMR reported in various marine ecosystems based on analyses of fishes. Our findings demonstrate that squid predation can significantly impact the early life survival of fish and the trophodynamics in marine ecosystems.