bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic sleeve gastrectomy for treatment of type 2 diabetes mellitus in adolescents
Authors: Mostafa Mohamed Saber , Youssef Ahmed Abdelhaseeb , Soliman Mohamed Hisham 
Published: January 2022

Abstract
Background
Metabolic diseases have been associated with childhood obesity no longer restricted to adults as previously known. Hypertension and diabetes mellitus (DM) have been reported in children with morbid obesity. Laparoscopic sleeve gastrectomy (LSG) has been used as a primary procedure for weight control among children and adolescents with acceptable records of effective weight loss together with evidence of improvement of associated co-morbidities.

Results
Thirty-two patients were diagnosed with morbid obesity and DM presented to obesity and nutrition clinic and were included in this study. Laparoscopic sleeve gastrectomy (LSG) was the chosen operation to treat their obesity and associated co-morbidities. Fasting blood sugar and HbA1c were measured before the operation and 1 year after surgery. Twenty-seven patients had significant improvement of their glycemic profile and managed to stop the hypoglycemic medication.

Conclusion
LSG may play an important role as a metabolic control procedure rather than a bariatric restrictive procedure only.
Prevalence, predictors and types of unpleasant and adverse effects of meditation in regular meditators: international cross-sectional study
Authors: Pauly Luca , Bergmann Niklas , Hahne Inge , Pux Sarah , Hahn Eric , Ta Thi Minh Tam , Rapp Michael , Böge Kerem 
Published: January 2022

BackgroundMeditation is commonly implemented in psychological therapies since the ‘third wave’ of cognitive–behavioural therapy has increased the focus on mindfulness-based interventions. Although extensive research literature demonstrates its benefits, little is known about potential adverse effects.AimsThe aim of this study is to report the prevalence, type and severity of particularly unpleasant meditation-related experiences in the largest cross-sectional study on this topic to date, with 1370 regular meditators.MethodThe participants were asked whether they ever encountered particularly unpleasant experiences as a result of their meditation experience. For the first time, the type and severity of those experiences were assessed and the association with several predictors, such as pre-existing mental disorders, were explored via logistic and linear regression.ResultsSimilar to previous studies, 22% of participants (95% CI 20–24) reported having encountered unpleasant meditation-related experiences, and 13% of participants (95% CI 3–5) reported experiences that were categorised as adverse. Those were mostly of affective, somatic and cognitive nature. Unpleasant meditation-related experiences were more likely to occur in participants with pre-existing mental illnesses (P= 0.000, 95% CI 1.25–2.12).ConclusionsThis study demonstrates that unpleasant meditation-related experiences are prevalent among meditators and, to a relevant extent, severe enough to warrant further scientific inquiry. Longitudinal studies are needed to examine whether the unpleasant meditation-related experiences are merely negative and thus should be avoided, or are an inherent part of the contemplative path.
Effectiveness of a program of the comprehensive correction of foot arch disorders in young athletes aged 7-8 years specialised in taekwon-Do I.T.F.
Authors: Danyshchuk Andrii , Ivanyshyn Iryna 
Published: January 2022

Introduction. A number of scientists have proven the positive effect of taekwon-Do I.T.F. on the physical state of people of all ages, the state of their musculoskeletal system. However, in the scientific literature there is no data on the effectiveness of taekwon-Do I.T.F. use in the programs of correction of foot arch (FA) disorders of young athletes. Similarly, no studies have been conducted on the effect of taekwon-Do I.T.F. exercises on the development of myofacsical kinematic chain (MFKC) of the lower limb and its role in the foot maintenance and correction in foot arch disorders. The purpose is to experimentally test the effectiveness of a comprehensive program for the foot arch disorders correction of young athletes by means of taekwon-Do I.T.F. Material and method. The following instrumental methods were used in the work: plantography (baropodograph using computer device “DIERS FAAMUS” (Germany)); electroneuromyography ("Neuro-EMG-Micro" made by "Neurosoft" (Russia)); photometry; myotonometry; formative consistent pedagogical experiment; methods of statistical data processing (Statistics 6.0 (StatSoft, USA)). Young athletes aged 7–8 with FA disorders and a normal foot took part in a 12-month formative experiment. Results. The value of the Friedland index, which characterizes the functional foot reserves, increased statistically significantly among EG1 young athletes who practiced according to the program developed by us, compared with those who were training according to the traditional program – by 6.48% against 3.85%, respectively. Conclusions. Analysis of FA morphological parameters of young athletes aged 7-8 years shows that the positive changes are statistically significantly more performed in young athletes who were training in the sports center "Taekwon-Do I.T.F." on a program of comprehensive correction, which is confirmed by FA changes.
Influence of fat-free, fat and sucrose diets on rat periodont condition
Authors: Pupin T. I. 
Published: January 2022

Aim. To investigate the effect of consumption of diets with different content of fat and sugar on the state of the periodontium of rats.Methods. The rats received a semi-synthetic fat-free diet (FFD), a fat diet (5 % sunflower oil), and a sucrose diet (50 % sucrose) for 30 days. Determined the degree of periodontal atrophy, tooth decay and in the gum homogenate - the activity of elastase, catalase, urease, lysozyme and the content of malondialdehyde (MDA).Results. Sugar diet increases the degree of periodontal atrophy and tooth decay, but decreases elastase activity in the gums and increases catalase activity. Fat diet does not affect periodontal atrophy and tooth decay, but it reduces catalase activity.Conclusion. The increase in the intensity of caries and periodontal atrophy under the influence of a sucrose diet is probably due to the stimulation of the formation of lactic acid. Fat nutrition does not affect the intensity of dental caries and the degree of periodontal atrophy.
A new algorithm of preoperative preparation of patients with focal lesions of the biliopancreatic area complicated by mechanical jaundice
Authors: Мuraviov Рetro , Zaporozhchenko Boris , Borodaev Igor , Shevcheko Valeria , Harhouri Makrem 
Published: January 2022

Pancreatoduodenal resection (PDR) represents one of the most demanding procedures which is required in patients with a tumoral lesion at this level. The aim of the present article was to report the results of 272 patients submitted to such surgical procedures. All patients were divided into two groups: the main group, for whom the optimized decompression algorithm was used (n=112) and the control group, for whom preparation for PDR was carried out according to generally accepted standards (n=160). Upon admission to the hospital, the total bilirubin level in the main group was 274.6±5.9 µmol/l while in the control group this level was 270.4±4.6 µmol/l. PDR was performed in 272 of the patients. Whipple’s terminolateral anastomosis was performed in 38/160 (23.7%) of patients in the control group; termino-terminal anastomosis according to Shalimov-Kopchak’s method was imposed in 40/160 (25.0%) patients of the control group. Pancreatojejunoanastomosis with the imposition of a ductomucosal anastomosis was performed in 128 patients in total with 73 cases in the main group and in 55 cases in the control one. Pancreatogastroanastomosis with plunging of the pancreatic stump into the stomach stump was performed in 35 patients in total with 19 patients in the main group and 16 in the control group. Pancreatogastroanastomosis with plunging of the pancreatic stump into the ‘stomach sleeve’ was performed in 32 patients in total with 20 patients in the main group and 12 in the control group. The mortality rate in the main group was 6.3% (7 patients), and in the control group, 11.9% (19 patients). In conclusion, biliary decompression may improve the postoperative outcomes after pancreatic resection.
Abbreviations: CEA, carcinoembryonic antigen; CA, cancer antigen; PDR, pancreatoduodenal resection; MRI, magnetic resonance imaging
Cognitive symptoms associated with antipsychotic course experience in residual schizophrenia
Authors: Safonov D. 
Published: January 2022

Urgency. The cognitive symptoms of schizophrenia are recognized either as a part of a negative complex of symptomatic, where cognitive malfunction seem to be the secondary complication of emotional and motivational dysregulation; or as a separate group of schizophrenia manifestations that constitutes a massive part of a residual condition. Aim – to evaluate the cognitive functioning and analyze its violation levels in association with antipsychotic course experience in patients with residual schizophrenia. Results. The assessment of cognitive functions was established by direct testing in clinical setting. Education in years varied from 9 to 16, mean 11,27±2,12 in the population under study. The basic level of cognitive impairment was established: verbal memory test result was 31,6±11,6; digit sequencing test result was 13,4±5,7; token motor task test result was 40,1±18,3; verbal fluency test result was 41,2±10,7; symbol coding test result was 30,6±13,1; tower of london test result was 12,2±4,5. Some correlations were found: for chlorpromazine we can assume minor negative impact on token motor task (r= -0,22) and verbal fluency test (r= -0,27) results; for haloperidol we can assume more pronounced but still minor impact on token motor task (r= -0,22), verbal fluency test (r= -0,27), verbal memory test (r= -0,28) and tower of London test (r= -0,20) results; for trifluoperazine we can see minor negative impact on verbal fluency test (r= -0,26); for clozapine we can’t find any representative correlations with cognitive tests; chlorprothixene as we can assume have minor negative impact on verbal memory test (r= -0,32) result, but minor positive – on tower of London test (r= 0,21) result; for risperidone also assume minor positive impact on sequence coding test (r= 0,25), but other tests in battery show no significant correlations; for zuclopenthixol we can assume minor negative impact on token motor task (r= -0,22) and verbal fluency test (r= -0,31) results.
Metabolic syndrome: review
Authors: Bobrova M. , Vorona S. , Koval S. , Savytskyi I. , Merza Y. , Savytskyi V. 
Published: January 2022

The psychosomatic component of the metabolic syndrome, historical aspect of the problem under study, physiological and biochemical mechanisms of pathogenesis are considered in the article. The symptomatic components of the metabolic syndrome and their interrelation are outlined, the ways of diagnosis and therapy and directions of modern research in this field are outlined.
State of proteolytic and fibrinolytic processes in the brain of rats with experimental diabetes mellitus complicated by cerebrovascular accident in the basin of the carotid arteries
Authors: Tkachuk S. , Tkachuk O. , Povar M. , Yasinska O. , Denysenko O. 
Published: January 2022

Introduction. The imbalance in the protease-antiprotease system is an integral part of the pathogenesis of acute disorder of cerebrovascular circulation and diabetes mellitus (DM), but its manifestations in the complication of diabetes by ischemia-reperfusion of the brain have not been investigated yet.
The objective of the work – to study the dynamics of carotid ischemia-reperfusion effect on the proteo- and fibrinolytic activity in brain structures of rats with experimental DM.
Rats with the four-month streptozotocin DM were modeled bilateral carotene ischemia during 20 minutes. In homogenates of brain structures, indicators of proteo- fibrinolytic activity were determined after 1 hour from the beginning of reperfusion and during the 12th day of the post-ischemic period. In the absence of DM, the proteolytic activity of all or individual indicators il increased in both periods of the post-ischemic period in the cortex of the frontal and occipital lobes, the fields of hippocampus CA2 and CA3, and during the 12th day in the field CA1.
Results. In rats with diabetes, in all brain structures, there are no changes in the lysis of azo-albumin and azo-casein in both terms of observation and lysis of collagen progressively decreases. In rats without DM in the cortex of the studied particles, fields of the hippocampus CA1 and CA2, all or separate indices of fibrinolytic activity are increased in both periods of the post-ischemic period, in the field CA3 – all indices at the 12th day. In the presence of diabetes in the cortex of both studied lobes and the field CA1, the fibrinolytic activity decreases in the late post-ischemic period, in the fields of CA2 and CA3 – during both observation periods.
Conclusion. In the brain structures under investigation at both time intervals, the DM eliminates the reaction of low and high molecular weight proteins to the ischemia-reperfusion and suppresses fibrinolytic activity.
Conservative treatment of the longitudinal flatfeet in children
Authors: Shulga O. 
Published: January 2022

Introduction. A significant percentage of the musculoskeletal system pathology in children is currently fall on the foot pathology – longitudinal flatfeet, which is not only a medical, but also a social problem. The incidence of this pathology is up to 58% of the total orthopedic foot pathology.
Traditional methods of treatment and prevention of mild (I– II severity) longitudinal flatfeet (LF), which are known today (massage, physiotherapy exercises, the use of orthopedic devices, electromyostimulation) do not give a significant effect and a stable, long-term result. This makes us look for more effective methods of conservative treatment of LF of the I– II severity degree, which have a pathogenic orientation and physiological effect.
Purpose of the work: to develop the most effective algorithm for the complex conservative treatment of LF, depending on the severity, hemodynamic disorders, deformity options, foot rigidity.
Materials and methods. Conservative treatment was carried out in 62 patients aged 10– 18 years with LF of the I– II severity degree. Depending on the clinical manifestations and examination results, the treatment was carried out in two stages. At the first stage, serial casting was used (in the presence of concomitant deformations – silicone pelottes were used).
Results. The results of the two-stage conservative treatment of LF demonstrate the effectiveness of serial casting in combination with the use of silicone pelottes and biostimulators in comparison with traditional methods of foot correction.
Conclusions. Algorithms for conservative treatment of LF were developed, depending on the severity, nature of the deformity, hemodynamic disorders and muscle tone of the lower leg and foot.
"Krajoznawstwo” in relation to different forms of active and cognitive tourism
Authors: Poczta Joanna , Rozmiarek Mateusz 
Published: January 2022

The main goal of the manuscript is an attempt to show that contemporary trends in tourism are based on forms in which cognitive, adventure and educational tourism is becoming more and more important. All these forms are based on the natural, cultural and historical heritage of the regions. In Poland, “krajoznawstwo” is an important trend, which for years has been based on the educational, cognitive and active tourism functions. It turns out that it is very difficult to find an equivalent of this word in English, but the message "get to know your country" can be carried out anywhere, in any part of the world. We decided to use the word "touring" in the text.
Therapeutic and preventive effect of feed additives on the state of periodonts of rats with experimental dysbiosis
Authors: Levitsky A. , Markov A. , Pupin T. , Selivanskaya I. , Lapinskaya A. 
Published: January 2022

Aim. Determine the therapeutic and prophylactic effect of feed additives on the condition of the periodontium in case of dysbiosis.
Methods. As feed additives, we used flour from pea straw (FPS), oilcake from ordinary (high-linoleic) sunflower seeds (OOS) and oilcake from high-oleic sunflower seeds (OHOS), which were added to the composition of feed for rats in an amount of 10% instead of the same amount of grain wheat. The duration of feeding was 18 days. Experimental dysbiosis was reproduced using the antibiotic lincomycin. The activity of urease, lysozyme, catalase, elastase and the content of malondialdehyde (MDA) were determined in the gums of rats.
Results. An increase in the level of urease, elastase, MDA and a slight decrease in the activity of lysozyme and catalase were found in rats with dysbiosis. The consumption of FPS and OOS had little effect on the biochemical parameters of the gums; however, the consumption of OHOS significantly reduced the activity of elastase, the level of MDA and normalized the level of urease.
Conclusion. Under conditions of dysbiosis, periodontitis develops, which can be prevented by consuming high-oleic sunflower oilcake.
The role of microbiota in pathogenesis and development of viral infections
Authors: Maksymowicz Marcela , Ręka Gabriela , Machowiec Piotr , Piecewicz-Szczęsna Halina 
Published: January 2022

Introduction and purpose
The microbiota plays an important role in human metabolism, immune system, and development of many chronic diseases, cancers, and infectious diseases. The aim of the study is to present the role of gut microbiota in viral infections, including HBV, Herpesviridae, HIV, and SARS-CoV-2. The newest publications from the last 5 years available on the PubMed database were taken into account.
A brief description of the state of knowledge
The mechanism by which bacterias have an impact on viral infection is based on a synthesis of specific short-chain fatty acids (SCFAs) and modulation of cytokine release and immune system function by bacterias. Domination of Gardnerella vaginalis and lack of Lactobacillus in the vaginal microbiome increased the risk of HSV-2 infection in women. Inflammation of the genital tract can influence susceptibility to HIV infection, but probiotics via enhancement of the gut barrier integrity, change TH17/Treg ratio, can restore microbiome composition. LPS - component of the structure of Gram-negative bacteria can be a marker of HBV infection. In the airway microbiome of patients with COVID-19 opportunistic microorganisms were identified.
Conclusions
Diet, intake of probiotics, fecal microbiota transplantation (FMT) are interventions that might be efficient methods in prophylaxis and treatment of viral diseases. Further studies are needed to evaluate the mechanism of action of microbiome in pathogenesis of infectious diseases.
Effects of ashwagandha root extract on physical performance – a clinical review
Authors: Mazur Karol , Lewicki Marcin , Mazur Dominika , Tyniec Mateusz , Smoleń Agata 
Published: January 2022

Sport is an important aspect of human life, affecting mental and physical health. Physical activity is one of the most effective ways of preventing the diseases of civilisation, such as coronary heart disease, hypertension, obesity and diabetes. There are many substances and methods that are used by athletes to improve physical performance, increase muscle mass and strength, increase concentration or suppress excessive emotions or reduce body weight to improve sports results. However, there is a need for research to find natural substances of plant origin, the use of which will lead to an increase in physical performance and will be fully legal and without side effects. Some scientists are conducting research into the use of ashwagandha root extract to improve physical performance.
The aim of this study was to assess the efficacy and safety of ashwagandha root extract in the treatment of insomnia, anxiety and in reducing stress. Our study material consisted of publications, which were found in PubMed, ResearchGate and Google Scholar databases. In order to find the proper publications, the search has been conducted with the use of a combination of key words like: ''ashawagandha'', ''physical performance'', ''physical endurance'', ''muscle strength". The first step was to find proper publications from the last 15 years. The second step was to carry out an overview of the found publications.
Anxiety in Angelman Syndrome
Authors: Grebe Stacey C. , Limon Danica L. , McNeel Morgan M. , Guzick Andrew , Peters Sarika U. , Tan Wen-Hann , Sadhwani Anjali , Bacino Carlos A. , Bird Lynne M. , Samaco Rodney C. , Berry Leandra N. , Goodman Wayne K. , Schneider Sophie C. , Storch Eric A. 
Published: January 2022

Abstract
Angelman Syndrome (AS) is a neurodevelopmental disorder most commonly caused by the impaired expression of the maternal UBE3A gene on chromosome 15. Though anxiety has been identified as a frequently present characteristic in AS, there are limited studies examining anxiety in this population. Studies of anxiety in other neurodevelopmental disorders have found disorder specific symptoms of anxiety and age specific displays of anxiety symptoms. However, there is a consistent challenge in identifying anxiety in people with neurodevelopmental disorders given the lack of measurement instruments specifically designed for this population. Given the limited information about AS and anxiety, the aims of the current project were to (a) examine symptoms of anxiety in children with AS and (b) determine the correlates of anxiety in children with AS. Participants included 42 adult caregivers of youth with AS in the AS Natural History study who completed the Developmental Behavior Checklist (DBC). The results found that 26% of the sample demonstrated elevated symptoms of anxiety and established a relationship between elevated anxiety in youth with AS and higher levels of irritability, hyperactivity, self-absorbed behaviors, and disruptive/antisocial behaviors. Findings from this research provide a foundation for tailoring evidence-based assessments and treatments for youth with AS and anxiety.
Narrative Analysis in Adolescents With Fragile X Syndrome
Authors: Neal Corinne N. , Brady Nancy C. , Fleming Kandace K. 
Published: January 2022

Abstract
This study analyzed narratives of male and female adolescents with fragile X syndrome (FXS). The impact of structural language, cognition and autism symptomatology on narrative skills and the association between narratives and literacy were examined. Narratives from 32 adolescents with FXS (24 males, 8 females) were analyzed for macrostructure. Relationships between narrative macrostructure, language scores, cognitive scores, Childhood Autism Rating Scale-Second Edition scores and literacy skills were examined. Males produced more simplistic narratives, whereas the females' narratives were more complex. Language scores predicted narrative scores above and beyond nonverbal cognitive skills and autism symptomatology. Narrative scores correlated with literacy scores. Narrative skills in FXS are predicted by language skills and are correlated with literacy skills. Investigation into narrative interventions in FXS is needed.