bluuebunny/crossref_metadata_2025_split huggingface dataset:
Roles of necroptosis in alcoholic liver disease and hepatic pathogenesis
Authors: Zhou Ying , Wu Ruoman , Wang Xinqi , Bao Xiaofeng , Lu Chunfeng 
Published: January 2022

AbstractChronic alcohol consumption can cause alcoholic liver disease (ALD), leading to morbidity and mortality worldwide. Complex disease progression of ALD varies from alcoholic fatty liver to alcoholic steatohepatitis, eventually contributing to fibrosis and cirrhosis. Accumulating evidence revealed that necroptosis, a way of programmed cell death different from apoptosis and traditional necrosis, is involved in the underlying pathogenic molecular mechanism of ALD. Receptor‐interacting protein kinase 1 (RIPK1), RIPK3 and mixed‐lineage kinase domain‐like pseudokinase have been implicated as key mediators to execute necroptosis. Also, necroptosis has gained increasing attention due to its potential association with primary pathological hallmarks of ALD, including oxidative stress, hepatic steatosis and inflammation. This review summarizes the recent progress on the roles and mechanisms of necroptosis and focuses on the crosstalk between necroptosis and the other pathogenesis of ALD, providing a theoretical basis for targeting necroptosis as a novel treatment for ALD.
Comparative evaluation of bite force in patients treated for unilateral mandibular condylar fractures by open and closed methods
Authors: Patel K. N. A. , Girish G. , Akarsh R. , Nikhila G. , Bhat Preethi , Shabadi Nikita 
Published: January 2022

AbstractBackground/AimCondylar fractures account for a large proportion (20% to 52%) of mandibular injuries. The goal of treating these fractures is to restore the occlusion, thereby re‐establishing the masticatory function as close as possible to the patient's pre‐trauma state. The aim of this study was to compare the bite forces following unilateral condylar fractures treated by open reduction and internal fixation (ORIF) with those managed by the closed method.MethodPatients with unilateral mandibular condylar fractures were divided into two groups (n = 20) using a simple randomization method. Patients in group I were treated by open reduction and internal fixation (ORIF) using titanium miniplates and screws. Patients in group II were treated by the closed method with inter‐maxillary fixation. Patients in both groups were evaluated pre‐operatively and then post‐operatively at one week, one month and three months for maximum bite force achieved at the central incisor, premolar and molar regions.ResultsPre‐operative bite forces on the unaffected site were significantly higher than the affected site in both groups, whereas no significant difference was observed in bite forces between the unaffected and affected sites in both groups post‐operatively. The bite forces achieved at both the unaffected and affected sites in the ORIF group were significantly higher than in the closed group.ConclusionMaximum bite forces differed significantly when the treatment was done with the open method, and the patients treated with the open method needed less time to achieve the maximum bite forces, thereby making an earlier return to function.
A unique sense of smell: development and evolution of a sexually dimorphic antennal lobe – a review
Authors: Williams Aidan T. , Verhulst Eveline C. , Haverkamp Alexander 
Published: January 2022

AbstractPheromones are pivotal to sexual communication in insects. These chemical signals are processed by sexually dimorphic circuitries in the antennal lobe (AL) of the insect brain. However, there is limited understanding of how these circuitries form during AL development. Our review addresses this issue by comparing how circuitries develop throughout the growth processes of peripheral and deutocerebral neurons in various insect orders. Olfactory sensory neurons (OSNs) expressing novel pheromone receptors are eligible candidates to initiate new sexually‐dimorphic circuitries when these OSNs survive programmed cell death and match the physiological properties of pheromone‐sensing sensilla. The probability of these OSNs forming new glomeruli is largely determined by the degree of glia‐OSN interactions and projection neuron (PN) prepatterning. The relative contribution of either of these processes determines the degree of evolutionary neuroplasticity, which is particularly prevalent in those species with complex ALs lacking specific macroglomerular structures. The extent of sexual dimorphism is determined by sex‐determination genes, such as Doublesex and Fruitless, that regulate factors inducing OSN programmed cell death. Currently, these mechanisms are largely unexplored. This review, therefore, aims to provide a solid foundation for ongoing research into the evolution of AL sexual dimorphism and formation of pheromone circuitries in the light of insect sex determination.
Association between case management and longitudinal decrease in negative symptoms in patients with first episode psychosis: A 2‐year follow‐up
Authors: Pelizza Lorenzo , Maestri Davide , Leuci Emanuela , Quattrone Emanuela , Azzali Silvia , Paulillo Giuseppina , Pellegrini Pietro 
Published: January 2022

AbstractAimNegative symptoms (NS) severely affect daily functioning already at the psychosis onset. However, most studies investigating beneficial effects of specific treatments for NS mainly included individuals with prolonged psychotic disorders. Furthermore, evidence on psychosocial rehabilitation for NS in early psychosis is still relatively poor. The aims of this study therefore were (A) to longitudinally examine NS stability in people with first episode psychosis (FEP) along a 2‐year follow‐up period, and (B) to overtime explore any relevant association of NS levels with the specific intervention components of an ‘early intervention in psychosis’ (EIP) protocol during the follow‐up.MethodsAt baseline, 266 FEP subjects (aged 12–35 years) completed the positive and negative syndrome scale (PANSS). Multiple linear regression analyses were then performed.ResultsAlong the follow‐up, FEP participants had a relevant improvement in NS levels. This was specifically predicted by the total number of case management sessions offered within our 2‐year EIP protocol, as well as by shorter duration of untreated psychosis at entry and by longitudinal reduction in PANSS depressive and positive symptom dimension levels. No association with antipsychotic medication was found.ConclusionsNS are clinically relevant in FEP, already at the recruitment time in specialized EIP services. However, their severity appears to improve over time together with the delivery of patient‐tailored, integrated EIP case management.
Attachment status is associated with grey matter recovery in adolescent anorexia nervosa: Findings from a longitudinal study
Authors: Lenhart Lukas , Gander Manuela , Steiger Ruth , Dabkowska‐Mika Angieszka , Mangesius Stephanie , Haid‐Stecher Nina , Fuchs Martin , Buchheim Anna , Sevecke Kathrin , Gizewski Elke Ruth 
Published: January 2022

AbstractThe aim of the present study was to investigate whether grey matter (GM) reductions in acute anorexia nervosa (AN) are (i) valid for adolescents (age 14–18 years), (ii) reversible following short‐term psychotherapeutic and nutritional therapy and (iii) depend on psychological components like attachment trauma. 3T MRI including a high‐resolution T1 MPRAGE was performed in 22 female adolescents in the acute state of AN (age: 15.2 ± 1.2 years) and after weight restoration (duration: 2.6 ± 1 months, n = 18) and compared with 18 gender‐matched healthy controls. The Adult Attachment Projective Picture System was used to classify resolved and unresolved attachment patterns. GM decreases were localized in extensive cortical areas including the insula, prefrontal and cingulate cortices as well as subcortical regions during acute AN, which partially increased after therapy with a relative sparing of the hippocampus and parahippocampal gyrus. The resolved group showed more GM recovery in regions of the left hippocampus and parahippocampal gyrus, bilateral cerebellar regions, right precuneus and adjacent cingulate cortices relative to the unresolved pattern. Structural anomalies in adolescent AN that recovered after treatment may be primarily the consequence of malnutrition, whereas several regions did not display significant recovery. Attachment status seems to influence region‐specific GM recovery.
Tight coupling between primary productivity, export production, and the growth of benthic scallops in the coastal region of the Okhotsk Sea along Hokkaido
Authors: Terumoto Takayuki , Kudo Isao , Miyoshi Koji , Shinada Akiyoshi , Miyazono Akira 
Published: January 2022

AbstractScallop culture is conducted worldwide, nonfeeding and depending on the natural phytoplankton production for the diet. It is necessary for sustainable culture of this species to understand how the phytoplankton production and subsequent vertical transport to the bottom (export production) are regulated by environmental factors. A 3‐year time series monitoring of chlorophyll and temperature, as well as sinking particle flux, was conducted to elucidate the relationship between surface primary production, the subsequent export, and the growth of benthic cultured scallops in spring in the coastal region of the Okhotsk Sea along Hokkaido, Japan. Five times larger export fluxes were observed in 2013 than those in other years. Coscinodiscus spp., diameter >200 μm, was the quantitatively dominant phytoplankton in 2013. This species contributed to the high export flux due to a higher settling velocity. The sudden drops in temperature by >2°C were observed during the study period. These indicated that the supply of nutrients from Intermediate Cold Water (ICW), a cold and nutrients rich water mass, accelerated the primary productivity in this area. This intensity was strongest in 2013, contributing to the high export flux. The large export flux in 2013 provided a more sufficient food to the benthic cultured scallops, resulting in a two times higher growth of the scallops than in other years. This study demonstrated that the size of the dominant diatom species and the supply from ICW strongly influenced the export ratio and the growth of cultured scallops.
Parental‐progeny‐based best linear unbiased prediction for determining maize single‐cross performance and resistance to Pythium root and stalk rot
Authors: Mitsuhashi Shohei , Tamaki Hiroyuki 
Published: January 2022

AbstractRoot and stalk rot (RSR) of maize (Zea mays L.) plants, caused by soil‐borne disease pathogens of the genus Pythium, can get worse in global warming. It has been known that the resistance of F1 hybrids often disaccords with those of their parental inbreds, which makes it difficult to develop resistant hybrids effectively. Best linear unbiased prediction (BLUP) is a standard mixed model equation, which is fitted for predicting hybrid performance by the parental inbreds of maize. The objective of this study was to evaluate simple parental‐progeny‐based BLUP in predicting single‐cross performance and to determine the importance of general combining ability of the resistance to Pythium RSR. The performance prediction of the parental inbreds from BLUP was consistent with empirical knowledge and was determined mostly useful, despite not using a coefficient of coancestry. Correlation coefficients between breeding values from BLUP and actual field data for hybrids, across different experiments from 2018 to 2019, were relatively high (R = 0.854 and 0.703, respectively). These results indicate the potential of the parental‐progeny‐based BLUP for maize single‐cross performance. This is the first report in predicting the resistance to this disease with BLUP, and the findings can be applied to routine breeding programs as well as to genome‐wide molecular polymorphism data to contribute to the future breeding programs.
New perspectives and analytical approaches to better understand academic inbreeding
Authors: Horta Hugo , Tavares Orlanda , Amaral Alberto , Sin Cristina 
Published: January 2022

AbstractThis is the introduction to a special issue focused on offering new perspectives and analytical approaches to better understand academic inbreeding. The seven papers of this special issue offer original analyses and new avenues of research on this highly resilient social phenomenon in academic settings. The findings and arguments forwarded by these papers can be used to further develop future studies and policies to curtail this practice, known to be detrimental to academia and scholarship.
A self‐portrait: Design opportunities for a tool that supports children's involvement in brain‐related health care
Authors: Meulendijks Paul , van Haren Neeltje E. M. , Gielen Mathieu A. , van Veelen‐Vincent Marie‐Lise C. 
Published: January 2022

AbstractIntroductionPaediatric patients with disorders that involve brain functioning are particularly vulnerable with respect to including them in shared decision‐making. Current tools are mostly paper or digital patient information. We lay the groundwork for improving engagement with a concept that we coined ‘the Self‐Portrait’. The main goals were to identify (1) obstacles and (2) design parameters that enable patient participation.MethodsA research‐through‐design approach was utilized in nine patients with brain‐related disorders (4–12 years), 15 parents and 15 medical professionals, involving contextual research (interviews and observations) within the paediatric hospital and patients' homes and codesign. Sensitizing materials and early instances of design solutions were deployed as catalysts for communication. Five rounds of enriched interviews and design reviews were thematically analysed to answer the research questions.ResultsObstacles to child involvement were related to children's level of understanding, the time and energy necessary for information processing and lack of perceived relevance of the information. Patients' engagement is supported by design features that extend the time frame of interaction beyond the consultation, transfer information interactively and give control and influence during the consultation.ConclusionObstacles were detected that complicate child engagement, which differ between stakeholders. Promising design features were identified that have the potential to play an important role in enabling active child involvement. These findings show that applying principles of human‐centred design research and codesign can bring together patients, parents and medical professionals around a tool that provides a shared language and focus, which are prerequisites to increase child engagement.Patient or Public ContributionPatients, parents and clinicians contributed as design informants during contextual research and design reviews. Clinicians provided feedback on the initial outcomes of thematic analysis. Two researchers assisted in consensus sessions during the thematic analysis.
Advancing literature review methodology through rigour, generativity, scope and transparency
Authors: Fan Di , Breslin Dermot , Callahan Jamie L. , Iszatt‐White Marian 
Published: January 2022

AbstractThe International Journal of Management Reviews (IJMR) is proud to offer a special section for articles that address methods and methodologies associated with undertaking literature reviews. In this editorial, we share our goals and aspirations for this special section. Drawing upon the motivations and objectives set out in 2020 and 2021 IJMR editorials, this editorial first discusses what potential benefits such an ongoing special section can bring to management and organization research in the longer term. In the next two sections, we detail what editors expect to see in the submissions we receive, and we also elaborate on some general and specific publication criteria as to how editors and reviewers will assess submissions related to methodology discussion. We hope this editorial will help authors avoid the disappointment of a rejection and encourage them to develop rigorous, innovative and impactful methodological advances and discussion.
The revival of nationalism in Europe and the immigration challenges in France
Authors: Berdiyev Ahmet , Can Nurettin 
Published: January 2022

AbstractThe European continent has been facing a significant challenge causing social, economic and political inequality among not only the countries, regions and cities but also the community members. What would be problematic within this broad context is to formulate a European immigration policy irrespective of framing a European immigration policy. Some primary issues, such as economic and employment integration, public goods sharing, ethnic and cultural diversity, social and political participation should be discussed in terms of the EU policy goals. Having applied the nationalism theory, this research scrutinizes nationalism and immigration influx in France. The study analysed that the French policy‐making process and the political rhetoric that influenced the immigration flow in France; those policies did not integrate the immigrants or stabilize France's situation. This analysis illustrates that France is becoming one of the toughest countries in Western Europe concerning its immigration laws and measures, which trigger the nationalistic sentiments. Nationalism, nevertheless, and its naturally opposing organization can also mutually boost anxieties and disputes in Europe, especially in France. The paper concludes that there is a paradigm shift in understanding immigration as a concept; throughout the twentieth century, it was considered a positive factor that proves France's attractiveness, which altered the perception of nation and the citizenship.
Prospective 5‐year clinical evaluation of posterior zirconia fixed dental prostheses veneered with milled lithium disilicate (CADon)
Authors: Blatz Markus B. , Hariton‐Gross Karina , Anadioti Evanthia , Mante Francis , Zhang Yu , Saleh Najeed 
Published: January 2022

AbstractObjectiveBi‐layer zirconia‐based posterior fixed dental prostheses (FDPs) have reportedly a high incidence of veneering ceramic fractures. The CADon technique employs zirconia frameworks veneered with milled lithium disilicate glass–ceramic to overcome these shortcomings but long‐term clinical studies are missing. This study evaluated the clinical efficacy of posterior 3‐unit CADOn FDPs over a 5‐year period.Materials and MethodsA total of 25 patients, 16 male and 9 female with a mean age of 55.6 years, received a total of 25 posterior three‐unit CADOn FDPs. Patients were recalled for baseline and for follow‐up visits at 6, 12, 24, and 60 months. Parameters evaluated were fracture, marginal adaptation, marginal discoloration, wear, polish, color match, surface staining, and retention of these restorations as well as secondary caries of the abutment teeth.ResultsA total of 21 FDPs evaluated at 60‐months revealed a 100% survival rate. All evaluated clinical parameters were satisfactory (alpha or bravo) and there was no statistically significant difference at different time points, except for surface staining, which was also worse at 60 months compared to baseline (p 0.001).ConclusionsCADOn three‐unit posterior FDPs demonstrate excellent fracture resistance after 5 years of clinical function. All evaluated clinical parameters were satisfactory, except for surface stain, which also increased over time.Clinical SignificanceConventionally veneered bi‐layer zirconia‐based posterior FDPs have limited clinical success. Based on this study, alternative methods such as zirconia frameworks veneered with milled lithium disilicate glass–ceramic provide a viable alternative with excellent long‐term clinical outcomes.
Multidisciplinary design: Creating a common perspective in complex cases
Authors: Cofar Florin , Barbur Ioan , Giordani Gustavo , Giordani Marcelo , Popp Ioana , Lascu Gabriela , Van Dooren Eric , Bratu Tiberiu , Blatz Markus 
Published: January 2022

AbstractObjectiveThis clinical report describes and illustrates digital treatment planning and interdisciplinary orthodontic, surgical, and prosthetic treatment in a highly complex clinical case.Clinical ConsiderationsAnalogue design protocols through wax ups are highly variable, technique sensitive, and operator dependent. Digital smile design and treatment planning tools facilitate simplified processes through the use of natural tooth libraries, based on the specific esthetic and functional needs of the individual patient. The vast information compiled in the virtual patient and the treatment plan consolidated in the initial digital design facilitate true interdisciplinary treatment planning and execution, with all dental specialties involved, from orthodontic to surgical and prosthetic treatment.ConclusionsDigital protocols and design tools provide clear clinical roadmaps for increased efficiency, precision, and predictability, vastly improving the quality of interdisciplinary patient care.Clinical SignificanceWhile analogue protocols are technique sensitive and largely dependent on the operator, digital smile design, and treatment planning tools offer opportunities for truly patient‐centered individualized care and interdisciplinary treatment.
Labor‐eliminating technology, wage inequality, and trade protectionism
Authors: Gilbert John , Koska Onur A. , Oladi Reza 
Published: January 2022

AbstractRapid automation in manufacturing has raised pressing questions in public and policy discourse regarding the effects of labor‐eliminating technical progress in an industry. We address the implications of a labor‐eliminating technology adopted in manufacturing for factor price changes, the skilled–unskilled wage gap, and for trade policies intended to protect workers. Using an otherwise traditional multisector general equilibrium model, we derive the conditions under which a labor‐eliminating technology will be adopted in manufacturing, and show that such a technical change will increase the rate of return on capital, and decrease both skilled and unskilled labor wages. We derive conditions under which wage inequality increases, and most importantly, show that implementing protectionist trade policies in the industry experiencing labor‐eliminating technical progress will, paradoxically, hurt the workers that the policy is meant to protect.
A retrospective multi‐center study of treatment, outcome, and prognostic factors in 34 dogs with disseminated aspergillosis in Australia
Authors: Lim Yi Yu , Mansfield Caroline , Stevenson Mark , Thompson Mary , Davies David , Whitney Joanna , James Fleur , Tebb Anna , Fry Darren , Buob Sibylle , Hambrook Lydia , Boo Gladys , Dandrieux Julien R. S. 
Published: January 2022

AbstractBackgroundDisseminated aspergillosis (DA) in dogs has a guarded prognosis and there is a lack of a gold standard treatment protocol.ObjectiveTo retrospectively assess survival times and factors influencing survival times.AnimalsDogs diagnosed with DA from January 2007 to June 2017.MethodsDisseminated aspergillosis case data were retrieved from 13 Australian veterinary referral centers, with a diagnosis confirmed with culture or PCR. Factors influencing survival time after diagnosis were quantified using a Cox proportional hazards regression model.ResultsThirty‐four dogs met the study inclusion criteria. Twenty‐two dogs were treated with antifungal treatment and 12 dogs received no antifungal treatment. Accounting for censoring of dogs that were either still alive on the date of data collection or were loss to follow‐up, dogs treated with itraconazole alone (n = 8) had a median survival time (MST) of 63 (95% CI: 20−272) days compared to 830 (95% CI: 267‐1259) days for the n = 14 dogs that received multimodal antifungal therapy ( test statistic 8.6; = 1;P < .01). The daily hazard of death (DHOD) for dogs with abnormally high serum creatinine concentration at the time of diagnosis was 7.4 (95% CI: 1.9‐29) times that of dogs with serum creatinine within the reference interval.Conclusion and Clinical ImportanceSerum creatinine concentration at the time of diagnosis is a useful prognostic indicator for survival after a diagnosis of DA. The MST for dogs treated with multimodal antifungal therapy is longer than itraconazole alone and warrant further investigation (P < .01).