bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dihydroartemisinin Inhibits Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular AMD
Authors: Li Xun , Gao Sheng , Zhang Yun , Xin Mei , Zuo Cheng , Yan Naihong , Xia Qingjie , Zhang Meixia 
Published: February 2022

Purpose: Choroidal neovascularization (CNV) is the main pathogenic process and a leading cause of severe vision loss in neovascular age-related macular degeneration (AMD). We investigated the antiangiogenic efficacy of dihydroartemisinin (DHA) in an experimental laser-induced CNV mouse model.Methods: After fluorescein angiography confirmed that CNV was induced by laser photocoagulation in C57BL/6J mice, DHA or vehicle was given by intragastric administration once a day. On day 6 and day 12, fluorescein angiography, optic coherence tomography, and flat-mounting analysis were performed to grade CNV leakage, measure CNV thickness and evaluate CNV areas, respectively. Immunofluorescence staining and Western blot analysis were performed to evaluate the expression of NF-κB, VEGF, and VEGFR2. To confirm the safety of intragastric DHA application, changes in retinal morphology and neural cell apoptosis were tested by histopathological examination and TUNEL assay, and retinal function was determined by electroretinogram (ERG).Results: Intragastric administration of DHA significantly suppressed CNV leakage and CNV formation in both thickness and area. Immunofluorescence showed that DHA suppressed VEGFR2 and NF-κB p65 expression in laser-induced lesions. Compared to the normal group, the protein expression of VEGF, VGFER2, NF-κB p65, and NF-κB1 p50 increased significantly in the vehicle group after laser photocoagulation, while it was profoundly inhibited by DHA treatment. In addition, histopathological examination, TUNEL analysis, and ERG test showed no obvious evidence of retinal toxicity caused by DHA.Conclusion: Systemic administration of DHA can effectively inhibit laser-induced CNV formation in mice, which might be due to the suppression of the classic NF-κB signaling pathway and downregulation of VEGFR2 and VEGF expression. The current results suggest that DHA could be a natural potential alternative therapeutic strategy for neovascular AMD.
Unequal Bandpass Filtering Power Divider Based on Hybrid HMSIW-SSPP Modes
Authors: Pan Bai Cao , Yu Ping , Guo Ben Jian , Qian Ya Hui , Luo Guo Qing 
Published: February 2022

This letter presents a novel unequal bandpass filtering power divider based on hybrid-mode of half mode substrate integrated waveguide (HMSIW) and spoof surface plasmon polaritons (SSPPs). Bandpass response is achieved by combining the transmission properties of HMSIW and SSPPs simultaneously. The operating bandwidth can be designed in a wide range by simply optimizing the dimensions of HMSIW and SSPPs. In addition, defected ground structures (DGSs) are etched on the bottom of the substrate to improve out-of-band suppression. The power division ratio of the proposed unequal power divider is finally optimized to 1:3. The measured results agree with the simulated one. Such design provides a stable power division within wide frequency range from 6.5 to 9.5 GHz.
Application of the RE-AIM Framework for the Pediatric Mild Traumatic Brain Injury Evaluation and Management Intervention: A Study Protocol for Program Evaluation
Authors: Tucker Paula W. , Bull Rachel , Hall Alex , Moran Tim P. , Jain Shabnam , Sathian Usha , Simon Harold K. , Gioia Gerard A. , Ratcliff Jonathan J. , Wright David W. 
Published: February 2022

BackgroundChildren who experience a mild Traumatic Brain Injury (mTBI) may encounter cognitive and behavioral changes that often negatively impact school performance. Communication linkages between the various healthcare systems and school systems are rarely well-coordinated, placing children with an mTBI at risk for prolonged recovery, adverse impact on learning, and mTBI re-exposure. The objective of this study is to rigorously appraise the pediatric Mild Traumatic Brain Injury Evaluation and Management (TEaM) Intervention that was designed to enhance diagnosis and management of pediatric mTBI through enhanced patient discharge instructions and communication linkages between school and primary care providers.MethodsThis is a combined randomized and 2 × 2 quasi-experimental study design with educational and technology interventions occurring at the clinician level with patient and school outcomes as key endpoints. The RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance) framework will be utilized as a mix methods approach to appraise a multi-disciplinary, multi-setting intervention with the intent of improving outcomes for children who have experienced mTBI.DiscussionUtilization of the RE-AIM framework complemented with qualitative inquiry is suitable for evaluating effectiveness of the TEaM Intervention with the aim of emphasizing priorities regarding pediatric mTBI. This program evaluation has the potential to support the knowledge needed to critically appraise the impact of mTBI recovery interventions across multiple settings, enabling uptake of the best-available evidence within clinical practice.
Microplastic Pollution in Surface Waters of Urban Watersheds in Central Texas, United States: A Comparison of Sites With and Without Treated Wastewater Effluent
Authors: Stovall Jasmine K. , Bratton Susan Power 
Published: February 2022

Most studies of microplastics in freshwater have investigated presence in creeks and rivers below sewage effluents and storm drains. This study examines microplastic distribution in surface waters, including springs and primary streams, located within small, urban Karst watersheds, with and without sources of wastewater treatment discharge. Study locales were in Texas, United States, either in Waco on the Brazos River or in or downstream from San Marcos on the San Marcos River. Research teams collected 800 ml surface water from four different small watersheds and an urban pond (n = 779) and filtered them through 53 μm Nitex mesh. Teams collected samples from springs or primary streams to the lower end of creeks and across stream transects based on distance from the bank and the presence of vegetation and debris. Teams also replicated samples seasonally. Stereo microscopy examined each filter for microplastic particles and subsequently color and type (i.e., fragment, fiber, or sphere). Additionally, we analyzed the influence of urbanization and land use on the origin and transport of the microplastics. Overall, the filters recovered 1,198 microplastic fibers and fragments. On average, 56.7% of all samples at each study locale contained microplastics. Particle abundance was the highest at Proctor Springs (x¯=3.38) and lowest at the pond (x¯=0.98), both headwaters. Local human use and runoff were thus potentially important factors in microplastic presence, while sewage discharge was not unilaterally the primary determinant of microplastic abundance. Peak pollution events occurred in June, September, and October, indicating seasonality of rainfall and recreation affected microplastic frequency and type.
Risk Factor of Posthemorrhagic Hydrocephalus: Cerebrospinal Fluid Total Protein
Authors: Wang Zhiwen , Chen Yuxin , Zhou Xinhui , Wang Changfeng , Chen Xianjun , Min Feixiang , Liu Ruen , Xiang Hui 
Published: February 2022

ObjectiveCerebrospinal fluid total protein (CSF-TP) levels in adults with posthemorrhagic hydrocephalus (PHH) are poorly studied. The objective of this study was to explore the characteristics of CSF-TP levels in patients with PHH.MethodsThe clinical data of 156 patients with hemorrhagic brain disease were retrospectively studied and divided into PHH and NPHH groups. Single-factor and multi-factor analyses were performed, and the key role of CSF-TP was evaluated using linear analysis.ResultsAmong the 156 patients, 85 (54.5%) had PHH and 34 (21.8%) underwent surgeries. Hypertension (p = 0.017), days [total fever time when body temperature ≥ 38.5°C (p = 0.04)], Glasgow Coma Scale (GCS) score (p &lt; 0.001), and time (from the onset of the disease to the obtainment of CSF-TP after lumbar puncture (p &lt; 0.001) were important factors for PHH. Logistic regression analysis revealed that GCS score &lt; 8 [odds ratio (OR) = 2.943 (1.421–6.097), p = 0.004] and CSF-TP × time ≥ 9,600 [OR = 2.317 (1.108–4.849), p = 0.026] were independent risk factors for PHH. All CSF-TP values were averaged every 2 days. CSF-TP was negatively correlated with time. Linear analysis showed that CSF-TP in the PHH group was higher than that in the NPHH group at the same onset time, and that the duration of detectionin the CSF was longer.ConclusionCerebrospinal fluid total protein (CSF-TP) × time ≥ 9,600 and GCS score &lt;8 were independent risk factors for PHH. CSF-TP was higher in the PHH group than in the NPHH group.
Pathological Features and Prognosis of Thymoma With or Without Myasthenia Gravis
Authors: Zhang Yunfeng , Yu Lei , Ke Ji 
Published: February 2022

IntroductionTo evaluate the different pathological and clinical characters of thymoma with and without myasthenia gravis (MG) and to determine whether the presence of MG influences the prognosis in patients with thymoma.MethodsFour hundred and twenty-five consecutive patients operated was analyzed. A median sternotomy was used in 189 cases, and video-assisted thoracoscopic thymectomy was used in 236 cases. These patients with thymoma were subdivided into two groups: thymoma with myasthenia gravis MG (n = 220) and thymoma without MG (n = 205). All thymic epithelial tumors were classified according to the WHO histologic classification and the Masaoka clinical staging system. The result was evaluated according to the Myasthenia Gravis Foundation of America's criterion. The clinical features of the 2 test were compared between the two groups, and the survival analysis of Cox treatment effects was compared between the two groups.ResultsThere were no perioperative deaths. The proportions of type A and thymic carcinoma were 0% in the group with MG and 10.7% (22/205) and 11.2% (23/205), respectively, in the group without MG. Thymic hyperplasia around the thymoma was 29.1% (64/220) in patients with MG and only 6.3% (13/205) in patients without MG (χ2 = 23.63, P = 0.000). The overall survival curve showed that the 5- and 10-year survival rates in the group without MG were 89.2 and 77.4%, respectively, while those in the MG group were 91.1 and 80.5%.ConclusionsThe existence of MG has little influence on the prognosis of thymomas, but it is suitable for early diagnosis and treatment. Extended thymectomy should be performed on all patients with thymoma, whether they have MG or not.
The Top-Cited Articles With a Focus on Barrett's Esophagus: A Bibliometric Analysis
Authors: Gan Peiling , Fan Wentao , Zhang Hailong , Zhong Chunyu , Xia Huifang , Lü Muhan , Zhou Xian , Tang Xiaowei 
Published: February 2022

BackgroundBecause the number of published literatures with a focus on Barrett's esophagus (BE) that researchers must be familiar with has quickly increased in recent years, the significance of selective searching and summarization of bibliometrics is also increasing. It is, thus, very important to find a method that can quickly and effectively search the most influential medical science articles. Therefore, the objective of this study was to use bibliometric analysis to assess and characterize the most influential articles involving BE research.MethodsPublications on BE research were retrieved from the Web of Science Core Collection using the term “Barrett's esophagus.” Microsoft Excel 2016 and VOSviewer were used to further analyzed each article's citation number, title, journal, country, organization, category, and authorship.ResultsOn 14 June 2020, 5,389 records of BE research published until 2020 were retrieved. The citation number of the top 100 most-cited articles ranged from 208 to 824. Gastroenterology published 29 articles, which accounted for the largest number of top 100 articles (29%); however, among the top 500 most-cited articles, the American Journal of Gastroenterology published the largest number. Of the top-cited articles, the USA was by far the leading country in BE research and contributed most of the articles (n = 72). Among the academic institutions that produced the top 100 most-cited articles, the University of Washington (n = 12) was dominant. Sharma Prateek (n = 6) authored the largest number of most-cited articles. The USA contributed the most articles per year, and the time trend of the number of top 500 articles increased by 38-fold between 1987 and 2000. “Adenocarcinoma,” “high-grade dysplasia,” “cancer,” “diagnosis,” and “dysplasia” were the most influential keywords.ConclusionsThis study not only presents a historical perspective but also facilitated the recognition of the significant advances in this area by researchers. Furthermore, the current study serves as a guide in decision clinical practice decision-making and provides a valuable reference for further research.
Sigmoid Colon Cancer Masquerading as a Right Incarcerated Inguinal Hernia: A Case Study and Literature Review
Authors: Zhang Jianfeng , Tang Yujie , Wu Xueliang , Wang Guiying , Li Tian 
Published: February 2022

BackgroundIndirect inguinal hernia and sigmoid colon cancer are both common diseases, but carcinoma within the hernia sac is rare. We present a case of sigmoid colon cancer masquerading as a right incarcerated inguinal hernia. Since such a presentation is rare, and the correct diagnosis is usually made intraoperatively, there is still no consensus on the best treatment modality for such patients.Case PresentationA 70-year-old man presented to our hospital on September 20, 2020, with a right inguinal mass that had been painful for half a month, accompanied by symptoms of difficult defecation. The bulge was originally found at least 60 years before admission. There was no pain at the time; however, the mass enlarged progressively during the last 3 years. The right scrotum and groin area were obviously enlarged (~20 × 20 cm) and tender. Inside the scrotum, a circumscribed medium-hard mass (diameter 5 cm) that was palpable, with ill-defined borders and translational mobility was detected. The computed tomography (CT) scan showed a right blood vessel-containing strangulated inguinal hernia; the sigmoid colon showed focal wall thickening as it was in proximity to the inguinal hernia. Based on the biopsy results, a pathologic diagnosis of high-grade intraepithelial neoplasia was made. The preliminary diagnosis was that of sigmoid carcinoma and right incarcerated inguinal hernia. Emergency laparoscopic exploration, open sigmoid radical resection andright inguinal hernia repair were performed under general anesthesia. The patient recovered successfully and was discharged 1 week after the operation. One month after surgery, no discomfort and signs of recurrence were found.ConclusionsThe combination of colorectal cancer and inguinal hernia is uncommon, and detailed preoperative physical examination and imaging studies may contribute to the establishment of a correct diagnosis. The selection of appropriate surgical methods ensures good therapeutic results.
Analysis of the Effect of Phacoemulsification and Intraocular Lens Implantation Combined With Trabeculectomy on Cataract and Its Influence on Corneal Endothelium
Authors: Wang Bin , Tang Liqin 
Published: February 2022

ObjectiveThis study aimed to discuss the effect of phacoemulsification and intraocular lens implantation (PHACO + IOL) combined with trabeculectomy (TRAB) on cataracts and its influence on the corneal endothelium.MethodsWe selected 120 cataract patients admitted to our hospital from January 2018 to January 2021. According to different surgical methods, they were divided into the control group and the observation group. The observation group was treated with PHACO + IOL combined with TRAB, the control group only received PHACO. The clinical effect, ophthalmic-related parameters, corneal endothelium, complications, the satisfaction of the two groups were observed.ResultsThe total effective rate and total satisfaction rate of the observation group were significantly higher than the control group (P &lt; 0.05). One month after the operation, the vision and central anterior chamber depth of the observation group were higher than those of the control group, and intraocular pressure (IOP) was lower than that of the control group (P &lt; 0.05). One month after the operation, the corneal endothelial cell area and cell density in the observation group were not significantly different from those before operation (P &gt; 0.05). There was no significant difference in the total incidence of complications between the two groups (P &gt; 0.05).ConclusionThis study concluded that PHACO + IOL combined with TRAB has a good curative effect in the treatment of cataracts, which can improve the patients' vision and IOP, keep the functional integrity of corneal endothelial cells, and does not increase the occurrence of complications, the patients' satisfaction is high.
Nowe Stare Miasto w Elblągu – wieloaspektowość interwencji w obszarze zabytkowym
Authors: Wiśniewska Katarzyna 
Published: February 2022

Celem niniejszego artykułu jest przegląd zasad ingerencji w obszarze zabytkowym poprzez chronologiczne przedstawienie różnych koncepcji odbudowy Starego Miasta w Elblągu, jako teoretycznych podstaw odbudowy oraz ukazanie przemian w podejściu do projektowania nowej zabudowy w obszarze zabytkowym. Konsekwentna odbudowa Starego Miasta w Elblągu od prawie czterech dekad jest ugruntowana teoretycznie i dostosowana do współczesności. Poprzez przykłady i określenie faz odbudowy Starego Miasta w Elblągu, chciałabym poddać refleksji, czy retrowersja jest procesem dostosowującym się każdorazowo do nowych współczesnych potrzeb, czy raczej retrowersja jako autorska metoda zakończyła się w 2002 roku wraz z zaprzestaniem nadzorowania projektów przez jej autorkę i od dziewiętnastu lat obserwujemy po prostu proces budowy Nowego Starego Miasta.
PENGARUH TERAPI BERMAIN (MEWARNAI) TERHADAP TINGKAT STRES PADA ANAK USIA SEKOLAH YANG MENJALANI PHYSICAL DISTANCING DI RW 03 KELURAHAN KEDUNGDORO KECAMATAN TEGALSARI SURABAYA
Authors: Permatasari Galuh , Ernawati Dwi , Dwi Anggoro Sapto 
Published: February 2022

Abstract : Physical distancing is an action that used to stop the spread of covid-19 desease. Nowadays, the Physical distancing which is done have the impact of the children psychology problems such as stress. The purpose of this research is to examine the influence of coloring play therapy toward children's stress levels in a school age who is through the physical distancing at RW 03, kedungdoro village, Tegal sari districts, Surabaya city. The type of research was using quasy-eksperimental method with pre test-post control group design approach. The number of samples on this research were 52 children of school age and divided into 26 respondents into the intervention group and 26 respondents into the control group, by using simple random sampling techniques and questionnaire as a measuring instrument. The data analysis was using Mann Whitney and Wilcoxon Signed Rank Test. The result of this research showed that p value 0,001 (p < 0,05) had an influenced of coloring play theraphy toward children's stress level in a school age who was through physical distancing at RW 03, kedungdoro village, Tegal sari districts, Surabaya city. The implications of this research was to reduced stress in a school age who was through physical distancing by doing the coloring play therapy everyday during 20-30 minutes in a free time.
PERAN SUJOK DALAM REHABILITASI PECANDU NARKOBA DI PONPRES SALAFIYAH SABILUL HIKMAH MALANG
Authors: Wulandari Mayang , Mahadini Chantika 
Published: February 2022

Narkoba merupakan ancaman besar bagi generasi muda bangsa Indonesia. Survei dari Badan Narkotika Nasional (BNN) dan Lembaga Ilmu Pengetahuan Indonesia (LIPI) menunjukkan 2,3 juta pelajar atau mahasiswa di Indonesia pernah mengonsumsi narkotika. Sujok adalah metode di mana tangan dan kaki digunakan untuk perawatan medis. Tangan dan kaki memiliki sistem penyembuhan yang tepat untuk menyembuhkan penyakit pada tubuh manusia dalam hal ini akan digunakan untuk mengatasi kecemasan pada pecandu narkoba. Tujuan umum dari penelitian ini adalah untuk Menganalisis Pengaruh Intervensi Sujok Untuk Membantu Kesiapan Pecandu Narkoba Dalam Menjalani Rehabilitasi Di Ponpes Salafiyah Sabilul Hikmah Malang. Desain penelitian yang digunakan dalam penelitian ini merupakan pre-experimental design dengan pretest-postest design. Responden adalah 14 orang santri Ponpes Sabilul Hikmah yang mengalami kecanduan narkoba, data diambil dengan menggunakan URICA untuk mengetahui kesiapan responden dalam menjalani rehabilitasi dengan terapi sujok media cincin, hasil yang didapatkan adalah ada pengaruh terapi sujok menggunakan cincin pijat dalam mendukung kesiapan pecandu narkoba untuk mengikuti rehabilitasi. Bagi akademik, penelitian ini diharapkan dapat memberikan informasi baru tentang Intervensi Sujok Untuk Membantu Kesiapan Pecandu Narkoba Dalam Menjalani Rehabilitasi dan membuka kesempatan pengembangan keilmuan berkelanjutan melalui penelitian berikutnya tentang kecemasan pecandu narkoba.
System of scientific and information support of agricultural complex of Ukraine
Authors: Kapralyuk Oksana 
Published: February 2022

The article analyzes the current state of information resources formed at different levels of government. The characteristics of the national system of scientific and technical information on agriculture are presented. It is stated that the main users of scientific and technical information in the field of agriculture are the following three categories, selected according to the nature of activity: scientists; commodity producers; executives, managers. Features of their information support are given. It is noted that among the sectoral information systems, information systems play an important role in the development of the agro-industrial complex of the country: the Ministry of Economy, Trade and Agriculture of Ukraine, Ministry of Education and Science of Ukraine, National Academy of Agrarian Sciences of Ukraine and the systems of their subordinate organizations and institutions, as well as agricultural libraries, advisory services, UkrINTEI, State Enterprise "Ukrainian Research and Training Center for Standardization, Certification and Quality", the State Statistics Committee, industry associations, information portals and others. Together, they form an integrated information system. Effective and high-quality provision of information needs of agricultural specialists is impossible without the information resources, which are traditionally handled by the agricultural libraries headed by the National Scientific Agricultural Library (NSAL) of the National Academy of Sciences of Ukraine. The main priority of the latter is the disclosure and presentation of existing documents, as well as access to a wide range of physical and virtual users. In this direction, the active creation of its own electronic database "online catalog Ukragroteka" is active, with a total volume of more than 550 thousand records, of which 52 thousand — full-text publications. The tasks for the creation of the national agricultural bibliography, presented by 13 biobibliographic series, are successfully implemented. Since 1999 the systematic quarterly abstract journal "Agroindustrial Complex of Ukraine" has been published quarterly.