bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collection of cancer Patient Reported Outcome Measures (PROMS) to link with primary and secondary electronic care records to understand and improve long term cancer outcomes: A protocol paper
Authors: Stamp Elizabeth , Clarke Gemma , Wright Penny , Velikova Galina , Crossfield Samantha S. R. , Zucker Kieran , McInerney Ciarán , Bojke Chris , Martin Adam , Baxter Paul , Woroncow Barbara , Wilson David , Warrington Lorraine , Absolom Kate , Burke Dermot , Stables Graeme I. , Mitra Angana , Hutson Richard , Glaser Adam W. , Hall Geoff 
Published: April 2022

Introduction
More people are living with and beyond a cancer diagnosis. There is limited understanding of the long-term effects of cancer and cancer treatment on quality of life and personal and household finances when compared to people without cancer. In a separate protocol we have proposed to link de-identified data from electronic primary care and hospital records for a large population of cancer survivors and matched controls. In this current protocol, we propose the linkage of Patient Reported Outcomes Measures data to the above data for a subset of this population. The aim of this study is to investigate the full impact of living with and beyond a cancer diagnosis compared to age and gender matched controls. A secondary aim is to test the feasibility of the collection of Patient Reported Outcomes Measures (PROMS) data and the linkage procedures of the PROMs data to electronic health records data.

Materials and methods
This is a cross-sectional study, aiming to recruit participants treated at the Leeds Teaching Hospitals National Health Service Trust. Eligible patients will be cancer survivors at around 5 years post-diagnosis (breast, colorectal and ovarian cancer) and non-cancer patient matched controls attending dermatology out-patient clinics. They will be identified by running a query on the Leeds Teaching Hospitals Trust patient records system. Approximately 6000 patients (2000 cases and 4000 controls) will be invited to participate via post. Participants will be invited to complete PROMs assessing factors such as quality of life and finances, which can be completed on paper or online (surveys includes established instruments, and bespoke instruments (demographics, financial costs). This PROMs data will then be linked to routinely collected de-identified data from patient’s electronic primary care and hospital records.

Discussion
This innovative work aims to create a truly ‘comprehensive patient record’ to provide a broad picture of what happens to cancer patients across their cancer pathway, and the long-term impact of cancer treatment. Comparisons can be made between the cases and controls, to identify the aspects of life that has had the greatest impact following a cancer diagnosis. The feasibility of linking PROMs data to electronic health records can also be assessed. This work can inform future support offered to people living with and beyond a cancer diagnosis, clinical practice, and future research methodologies.
Predictors of histopathological esophagitis in infants and adolescents with esophageal atresia within a national follow-up programme
Authors: Donoso Felipe , Beckman Anna , Malinovschi Andrei , Engstrand Lilja Helene 
Published: April 2022

Purpose
Esophageal atresia (EA) is a congenital anomaly of the foregut. Although the survival has improved over the years there is a significant gastrointestinal morbidity affecting physical function and health-related quality of life. The aims of the study were to identify and evaluate predictors of histopathological esophagitis in infants and adolescents with EA.

Methods
Single centre, cross-sectional study including one and 15-year-old patients operated for EA that participated in the national follow-up programme between 2012 and 2020 according to a pre-established protocol including upper endoscopy with oesophageal biopsies and 24h-pH-test. Data was collected from patients’ medical records and pH-analysis software. Regression models were used to identify predictors of histopathological oesophagitis. Possible predictors were abnormal reflux index, endoscopic esophagitis, hiatal hernia, symptoms of gastroesophageal reflux (GER) and age.

Results
65 patients were included, 47 children and 18 adolescents. All children were treated with PPI during their first year of life. Symptoms of GER were reported by 13 (31.7%) of the infant’s caregivers, 34 of the children (72.3%) had abnormal reflux index and 32 (68.1%) had histopathological esophagitis. The corresponding numbers for adolescents were 8 (50%), 15 (83.3%) and 10 (55.6%). We found no significant associations between histopathological esophagitis and endoscopic esophagitis, symptoms of GER, hiatus hernia or age group. Abnormal reflux index was an independent predictor of histopathological esophagitis. Seven patients with normal reflux index had histopathological esophagitis, all grade I.

Conclusions
We found a high prevalence of histopathological esophagitis despite PPI treatment in accordance with recommendations. No significant difference between the two age groups was seen. Abnormal reflux index was an independent predictor of histopathological esophagitis. However, we cannot recommend the use of pH-metry as a substitute for esophageal biopsies; future studies are needed to elucidate if esophageal biopsies might be postponed in infants with normal reflux index.
To assess the determinants of family planning uptake among women of reproductive age in rural settings, Morogoro Region, Tanzania. Protocol for a cross-sectional study
Authors: Machange Margareth Danielistan , Munyogwa Mariam John 
Published: April 2022

Background
Maternal health outcomes in Tanzania had continued to be of great concern. According the Tanzania Demographic and Health surveys, maternal mortality is still unacceptable higher. Effective use of family planning is reported to prevent maternal deaths by more than 30%. However, the prevalence of family planning uptake is still lower especially in rural areas of this country despite the fact that family planning services are provided freely and at a subsidized cost in all public and private health care facilities respectively.

Objective of the study
The broad objective is to assess the determinants of family planning uptake among women of reproductive age in rural settings, Morogoro Region, Tanzania.

Methods
This study will be a cross-sectional study that will be conducted in rural areas of Morogoro Region. Study population will be women of reproductive age. Qualitative and quantitative approaches will be used to collect the data. Sampling techniques will involve stratification of urban and rural wards, simple and systematic random sampling for selection wards and households respectively and kish selection table for the selection one participant from a household. Purposive sampling will be applied to get participants for qualitative data. Data collection will be done by using semi-structured questionnaire and interview guide. Frequencies, percentages, chi-square test and logistic regression will be used to analyze the quantitative data whereas codes and themes formation will be used to analyze the qualitative data.
The impact of subject positioning on body composition assessments by air displacement plethysmography evaluated in a heterogeneous sample
Authors: Horhat Raluca , Miclos-Balica Monica , Muntean Paul , Popa Sandra , Sima Irina , Glisici Bogdan , Cîrja Onisim , Neagu Adrian , Neagu Monica 
Published: April 2022

Introduction
This study sought to evaluate the impact of subject positioning on body composition assessments by air displacement plethysmography using the BOD POD®.

Methods
Eighty-two adults (42 men and 40 women), aged 26.1 ± 8.4 y (mean ± standard deviation), body mass index = 23.6 ± 4.8 kg/m2, were assessed by repeated measurements in two different positions: relaxed (legs apart, back away from the rear) and compact (legs together, arms near the body, back touching the rear). We relied on Bland-Altman analysis to quantify the agreement between results recorded in the two positions. Using body surface charts, we tested the hypothesis that posture-induced variability stems from differences in exposed skin area.

Results
Switching from compact to relaxed position resulted in a bias of -197 mL for body volume, -1.53% for percent body fat, and 1.085 kg for fat-free mass. The body surface area in contact with air was larger in relaxed position by 3632 ± 522 cm2. When body volume was expressed in terms of the actual area of exposed skin in the compact position, the percent body fat bias became 0.08%, with a 95% confidence interval of (-0.14, 0.29)%.

Conclusions
Subject posture is a source of significant variability in air displacement plethysmography. The disagreement between results obtained in different positions can be eliminated by adjusting the surface area artifact, suggesting that subject positioning in the BOD POD® should be controlled to avoid changes in the amount of air maintained under isothermal conditions by the body.
Understanding child disability: Factors associated with child disability at the Iganga-Mayuge Health and Demographic Surveillance Site in Uganda
Authors: Zia Nukhba , Bachani Abdulgafoor M. , Kajungu Dan , Galiwango Edward , Loeb Mitchell , Diener-West Marie , Wegener Stephen , Pariyo George , Hyder Adnan A. 
Published: April 2022

Introduction
There is scarcity of data on children with disabilities living in low-and-middle-income countries, including Uganda. This study describes disability prevalence and explores factors associated with different disability categories. It highlights the value of using a standardized, easy-to-use tool to determine disability in children and contextualizing disability in children in light of their developmental needs.

Methods
A cross-sectional study was conducted between September 2018–January 2019 at the Iganga-Mayuge Health and Demographic Surveillance Site in Uganda. Respondents were caregivers of children between 5–17 years and were administered an in-depth Child Functioning Module (CFM). The outcome variable, disability, was defined as an ordered categorical variable with three categories–mild, moderate, and severe. Generalized ordered logit model was applied to explore factors associated with disability categories.

Results
Out of 1,842 caregivers approached for the study, 1,439 (response: 78.1%) agreed to participate in the study. Out of these 1,439, some level of disability was reported by 67.89% (n = 977) of caregivers. Of these 977 children with disability, 48.01% (n = 692) had mild disability and 15.84% (n = 228) had moderate disability, while 3.96% (n = 57) had severe disability. The mean (SD) score for mild disability was 2.22±1.17, with a median of 2. The mean and median for moderate disability was 5.26±3.28 and 4 (IQR:3–6), and for severe disability was 14.23±9.51 and 12 (IQR:6–22). The most common disabilities reported were depression (54.83%) and anxiety (50.87%). Statistically significant association was found for completion of immunization status and school enrollment when controlled for a child’s age, sex, having a primary caregiver, age of mother at child’s birth, family system, family size and household wealth quintile.

Conclusion
This study suggests association between incomplete immunization status and school enrollment for children with disability. These are areas for further exploration to ensure inclusive health and inclusive education of children with disabilities in Uganda.
Severe community-acquired pneumonia in Reunion Island: Epidemiological, clinical, and microbiological characteristics, 2016–2018
Authors: de Mangou Axel , Combe Agathe , Coolen-Allou Nathalie , Miltgen Guillaume , Traversier Nicolas , Belmonte Olivier , Vandroux David , Bohrer Michel , Cousty Julien , Caron Margot , Vidal Charles , Allyn Jérôme , Allou Nicolas 
Published: April 2022

Purpose
No data are available on severe community-acquired pneumonia (CAP) in the French overseas department of Reunion Island. This is unfortunate as the microorganisms responsible for the disease are likely to differ from those in temperate regions due to a tropical climate and proximity to other islands of the Indian Ocean region. The aim of this study was to assess the epidemiological, clinical, prognosis, and microbiological characteristics of patients with severe CAP in Reunion Island.

Materials and methods
This retrospective study evaluated all patients with CAP aged >18 years and hospitalized in one of the two intensive care units of Reunion Island between 2016 and 2018. Microorganisms were identified by culture from blood and respiratory samples, multiplex polymerase chain reaction from respiratory samples, urinary antigen tests, and serology.

Results
Over the study period, 573 cases of severe CAP were recorded, with a mean incidence of 22 per 100,000 person-years. The most frequently isolated microorganism was influenza (21.9%) followed by Streptococcus pneumoniae (12%). The influenza virus was detected in affected patients all year round. Twenty-four patients with severe CAP came from another island of the Indian Ocean region (4.2%), mainly Madagascar (>50%). Two of these patients presented with melioidosis and 4 were infected with Acinetobacter spp.

Conclusions
Our findings have major implications for the management of severe CAP in tropical regions. The most frequently isolated microorganism in patients with severe CAP in Reunion Island is influenza followed by S. pneumoniae. Physicians should be aware that influenza is the main cause of severe CAP in patients living in or returning from Reunion Island, where this virus circulates all year round.
Prevalence and associated factors of diabetes mellitus among Governmental Civil Servants at Guji Zone, Oromia Region, Ethiopia, 2021. A community-based cross-sectional study
Authors: Utura Takala , Fikrie Anteneh 
Published: April 2022

BackgroundDespite it being easily preventable, still diabetes mellitus is found in every population in the world and all regions, with the greatest escalation in low and middle-income countries. Moreover, undiagnosed or poorly controlled diabetes can lead to lower limb amputation, blindness, and kidney disease. However, there is a paucity of information on the magnitude and associated factors among adult populations in rural pastoral areas. Therefore, this study aimed to assess the magnitude of diabetes mellitus and associated factors among Guji Zone Government Civil Servants, Southern Ethiopia.MethodsCross-sectional study was conducted from March 1-14/2018, among 437 randomly selected Government employees of Guji Zone. A self-administered questionnaire was used to collect data. Data were coded and entered using Epi-data version 3.1 and exported to SPSS version 20 for analysis. Multivariable logistic regression analysis was done to identify significant factors associated with the magnitude of DM. P<0.05 was used to declare statistical significance and odds ratio with 95% confidence interval were calculated.ResultThe median (±IQR) age of participants was 33 (±14) years of age. Overall, the prevalence of DM in the study population was found to be 16 (3.9%) [95% CI: 2.2–5.6%]. The prevalence of DM among males and females was 3.8% and 4.2% respectively. Age (<35 years) [0.21 (0.04–0.94)], increasing salt amount in dietary feeding [14.31(1.28–159.2)], Consumption of vegetable &fruit once per week [23.38(2.01–269.17)], diagnosed with HTN [21.35(2.28–199.37)], and Family history of DM [9.42(1.72–51.42)] were significantly associated with DM.ConclusionComparably lower prevalence of previously undiagnosed DM was found by this study. Being old, excess salt consumption, intake of vegetables & fruit once per week, hypertension, and family history of DM were significantly associated with DM. Therefore, the zonal Health department should enhance and strengthen the provision of health education programs and counseling about nutrition, weight control, and appropriate physical activity and advised the communities for mass screening for diabetes.
Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysis
Authors: Jung Hae Do , Cho Kang Su , Moon Young Joon , Chung Doo Yong , Kang Dong Hyuk , Lee Joo Yong 
Published: April 2022

Introduction
A single dose of preventive antibiotics is known to be sufficient to reduce the rate of infection-related complications in percutaneous nephrolithotomy (PCNL). However, some studies reported that the extended dose showed lower complications for high-risk groups. Therefore, we performed a systematic review and meta-analysis comparing single- and extended-dose antibiotic prophylaxis for PCNL.

Materials and methods
Relevant studies that compared single- and extended-dose antibiotic prophylactic therapies were identified. Articles were selected from PubMed, EMBASE, KoreaMed, and Google Scholar up to September 2021. Fever and systemic inflammatory response syndrome (SIRS) were compared by meta-analysis. A subgroup analysis was performed according to the degree of risk to the patient.

Results
A total of 10 articles were included in this study. There were no significant differences between single dose and extended dose in the rate of fever [p = 0.93, OR = 0.96, 95% confidence interval (CI) 0.44–2.13, I2 = 64%]. Extended dose showed lower rate of SIRS compared to single dose (p = 0.0005, OR = 1.81, 95% CI 1.30–2.53, I2 = 53%); in the subgroup analysis, extended dose also showed lower rates of SIRS compared to single dose in high-risk patients (p <0.0001, OR = 3.53, 95% CI 1.91–6.54, I2 = 36%).

Conclusions
The results of our meta-analysis showed that single-dose antibiotic prophylaxis can be effective for PCNL, but extended-dose antibiotics can be required in high-risk patients to reduce post-PCNL infection-related complications.
Berber Memories: Women and Jewellery in Morocco, Michel Draguet (2021)
Authors: Bernabei Roberta 
Published: April 2022

Review of: Berber Memories: Women and Jewellery in Morocco, Michel Draguet (2021)
Brussels: Mercatorfonds and Yale University Press, 600 pp.,
ISBN 978-0-30025-395-5, h/bk, £65.00s
Pengaruh Peran Orang Tua dan Aksesibilitas Buah dan Sayuran terhadap Rendahnya Konsumsi Buah dan Sayur pada Anak Pra Sekolah di Kota Bima Nusa Tenggara Barat
Authors: Rostinah Rostinah , Nelly Nelly 
Published: April 2022

Early childhood is critical to the development of lifelong food habits. Given the high proportion of children with inadequate fruit and vegetable consumption, identification of modifiable factors associated with higher consumption may be useful in developing interventions to address this public health issue. The aim of the present study was to investigate factors that affect fruit and vegetable consumption in a sample of Mpunda districts preschool children. Methods using A cross-sectional telephone survey and questioner was conducted with 60 parents of 3 to 5 year-old children. Children’s fruit and vegetable consumption was measured using a valid and reliable subscale from the Children’s Dietary Questionnaire. Associations were investigated between children’s fruit and vegetable intake and characteristics of the home food environment including parental role-modeling, parental providing behaviour, fruit and vegetable availability, fruit and vegetable accessibility, pressure to eat, education and knowlwdge, family mealtime practices. Characteristics of the home food environment that showed evidence of an association with children’s fruit and vegetable consumption in simple regression models were entered into a backwards stepwise multiple regression analysis. The multiple regression analysis found positive associations between children’s fruit and vegetable consumption and parental fruit and vegetable intake (p = 0.004), and accessibility (p = 0.002).
Approximating coarse Ricci curvature on submanifolds of Euclidean space
Authors: Ache Antonio G. , Warren Micah W. 
Published: April 2022

Abstract
For an embedded submanifold Σ ⊂ ℝ
N
, Belkin and Niyogi showed that one can approximate the Laplacian operator using heat kernels. Using a definition of coarse Ricci curvature derived by iterating Laplacians, we approximate the coarse Ricci curvature of submanifolds Σ in the same way. For this purpose, we derive asymptotics for the approximation of the Ricci curvature proposed in [2]. Specifically, we prove Proposition 3.2 in [2].
Calculation of the estimated glomerular filtration rate using the 2021 CKD-EPI creatinine equation and whole blood creatinine values measured with Radiometer ABL 827 FLEX
Authors: Song Lu , Buggs Vincent , Samara Vishnu Amaram , Bahri Shadfar 
Published: April 2022

Abstract

Objectives
Estimated glomerular filtration rate (eGFR) can be calculated using serum/plasma creatinine measured with automated chemistry analyzers. It is unclear whether eGFR can be calculated using creatinine values measured in whole blood (WB creatinine). The aim of this study is to determine the comparability between the eGFR calculated using WB creatinine and plasma creatinine.

Methods
Blood samples from 1,073 patients presented to the emergency department (ED), perioperative areas, intensive care unit (ICU) or nuclear medicine were used to determine the accuracy of WB creatinine. For each sample, WB creatinine was first measured with Radiometer ABL827 FLEX blood gas analyzer, then plasma creatinine was measured with Roche Cobas702 chemistry analyzer after samples were centrifuged. In a subset of 247 samples with the information of age and sex, whole blood eGFR (WB eGFR) and plasma eGFR were calculated using WB creatinine and plasma creatinine and the 2021 chronic kidney disease epidemiology collaboration (CKD-EPI) creatinine equation, respectively.

Results
WB creatinine correlated with plasma creatinine linearly with a slope of 1.06 and an intercept of −0.01. The coefficient of determination (R2) was 0.99. WB eGFR correlated with plasma eGFR linearly with a slope of 0.95, intercept of −1.63, and R2 of 0.97. Comparing to plasma eGFR, the sensitivity and specificity for WB eGFR to identify those with high risk (eGFR<30 mL/min/1.73 m2) and low risk (eGFR>45 mL/min/1.73 m2) for kidney injuries was 100 and 92.2%, respectively. The overall concordance in classifying the four stages of kidney damage between WB eGFR and plasma eGFR was 87.9%.

Conclusions
WB creatinine measured with Radiometer ABL827 Flex can be used to calculate eGFR using the 2021 CKD-EPI creatinine equation. The sensitivity and specificity for WB eGFR to identify those with high and low risks for potential kidney injuries are acceptable in patients needing rapid assessment of their kidney functions.
Verbs of motion and intermediate source domains of modality: the understudied case of Italian occorrere ‘to be necessary, to be needed’
Authors: Dell’Oro Francesca 
Published: April 2022

Abstract
Though the emergence of modality from verbs of motion is a well-attested phenomenon, the assessment of cross-linguistically valid pathways still remains a desideratum. In this paper I offer an outline of the pathway followed by the understudied Italian modal verb occorrere ‘to happen; to be necessary/needed’ (from Latin occurrere, originally ‘to run towards, into something or someone’). Based on the analysis of two large corpora, this paper reconstructs the emergence of the impersonal constructions ‘occorre + INF’ and ‘occorre che + SBJV’ vis-à-vis the personal one (‘to be needed’). The data and their analysis confirm the complexity of the pathway: in fact, the emergence of modality is strongly interlaced with the co-presence of the ancient meaning ‘to happen’, but also with the emergence of a deontic construction in which occorrere assumes the function of the auxiliary essere (‘to be’) as well as with the later evolution of another construction with negative polarity and in which occorrere is a telic metaphoric verb of motion. Though the pathway followed by Italian occorrere could be idiosyncratic in a cross-linguistic perspective, its in-depth study sheds new light on the question of how modality emerges and in particular on its source domains and their relations.