bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protein-Energy Nutritional Status of Moderately Low Protein Intake-Sago Diets Compared to Sufficiently Protein Intake-Rice Diets in Well-Nourished Lowlanders in Papua, Indonesia
Authors: Syauki A. Yasmin , Ogawa Aki , Simanjuntak Uli Rina Pelegia , Mangiwa Ingrid Gloria , Doi Miki , Kageyama Suzumi , Inoue Rikako , Taslim Nurpudji A. , Irie Yasuyuki 
Published: February 2022

Background: Protein inadequacy is prevalent in developing countries because of the high consumption of starchy staple foods. Sago, as a staple food in Papua Province, was eaten with less protein. This study aimed to analyze the nutritional status of protein-energy in well-nourished adults of the moderately low protein in-take (MLP)-sago group compared to the sufficient protein intake (SP)-rice group, in lowland Mimika, Papua. Methods: This cross-sectional-analytic study was conducted on 50 participants. Twenty-four-hour food recall, body composition, albumin, and complete blood count were used to assess the nutritional status. Results: There were no differences in the body compositions and albumin levels between the MLP-sago and SP-rice groups. Multivariate linear regression showed that the mean corpuscular volume (MCV) (β = -0.524, P = 0.007) was a predictive factor for albumin in the sago group, while in the rice group, hemoglobin (β = 0.354 P = 0.089) and white blood cell counts (β = 0.396, P = 0.059) were predictive factors. Conclusions: The MLP-sago and SP-rice groups exhibited no differences in the body and visceral protein; however different predictors of albumin were found be- tween the groups, suggesting an adaptive mechanism in the MLP-sago group to maintain normal albumin levels.
Promoting Mobile Payment with Price Incentives
Authors: Ho Chun-Yu , Kim Nayoung , Rong Ying , Tian Xin 
Published: February 2022

Using a proprietary data set containing more than 10 million transactions over 14 months from hundreds of grocery stores, we examine consumer payment choices at point of sale (POS) between cash and mobile, where the use of other methods (including cards) is minimal. We find that cash is the dominant method of payment. Nonetheless, the share of mobile payments has increased at the expense of cash payments over time. Importantly, we exploit price incentives for consumers using mobile payment to examine the price substitution between cash and mobile payments. Our results show that consumers are more likely to use mobile payment when they receive price incentives for doing so, and such an effect persists for a few days, even after the price incentive expires. Nonetheless, the price incentives are unlikely financed by additional transactions paid via mobile but subsidized by mobile payment providers. Interestingly, we find several factors that enhance and supplement the steering effect of price incentives. First, a larger monetary reward seems to induce a stronger impact of price incentive on mobile payment. Second, the steering effect of price incentive is stronger for stores that serve consumers who have frequently been using mobile payment and for price-sensitive consumers. Third, the additional mobile payments come from transactions that would not have occurred with price incentive and those that switch from cash transactions.This paper was accepted by Eric Anderson, marketing.
An Optimal Streaming Algorithm for Submodular Maximization with a Cardinality Constraint
Authors: Alaluf Naor , Ene Alina , Feldman Moran , Nguyen Huy L. , Suh Andrew 
Published: February 2022

We study the problem of maximizing a nonmonotone submodular function subject to a cardinality constraint in the streaming model. Our main contribution is a single-pass (semi) streaming algorithm that uses roughly [Formula: see text] memory, where k is the size constraint. At the end of the stream, our algorithm postprocesses its data structure using any off-line algorithm for submodular maximization and obtains a solution whose approximation guarantee is [Formula: see text], where α is the approximation of the off-line algorithm. If we use an exact (exponential time) postprocessing algorithm, this leads to [Formula: see text] approximation (which is nearly optimal). If we postprocess with the state-of-the-art offline approximation algorithm, whose guarantee is [Formula: see text], we obtain a 0.2779-approximation in polynomial time, improving over the previously best polynomial-time approximation of 0.1715. It is also worth mentioning that our algorithm is combinatorial and deterministic, which is rare for an algorithm for nonmonotone submodular maximization, and enjoys a fast update time of [Formula: see text] per element.
Echinococcus multilocularis specific antibody, systemic cytokine, and chemokine levels, as well as antigen-specific cellular responses in patients with progressive, stable, and cured alveolar echinococcosis: A 10-year follow-up
Authors: Grüner Beate , Peters Lynn , Hillenbrand Andreas , Voßberg Patrick , Schweiker Jonas , Rollmann Elisabeth G. , Rodriguez Laura H. , Blumhardt Jasmin , Burkert Sanne , Kern Peter , Köhler Carsten , Soboslay Peter T. 
Published: February 2022

BackgroundThe infestation withEchinococcus multilocularislarvae may persist in humans for up to decades without evident clinical symptoms. Longitudinal investigations are needed to understand the dynamic immunological processes in alveolar echinococcosis (AE) patients associated with an active and progressive, a stable or a regressive course of disease.Methodology/Principal findingsThis study evaluated theE.multilocularisspecific antibody responses, systemic cytokine, and chemokine serum levels over a 10-year follow-up period, as well as cellular responsiveness in AE patients. Our results demonstrate a rapid decrease in antibodies againstE.multilocularisspecific antigen Em2+. Especially in cured patients, these antibodies remained negative, making them a significant predictor for cured AE.E.multilocularisspecific IgG4, and indirect hemagglutination IHA decreased later in time, after around 5 years. While total IgE did not show significant dynamics over the course of disease,E.multilocularisspecific IgE decreased after one to two years, and increasing levels were a significant predictor of progressive disease. There was no significant change in systemic IL-8, IL-9, CCL18 or CCL20 serum levels over time. Univariate analysis across groups indicated lower IL-8 levels in cured patients; however, this result could not be confirmed by multivariate analysis. Levels of CCL17 decreased during treatment, especially in cured patients, and thus might serve as a predictive or risk factor for progressive disease. Levels of IL-10 and CCL13 decreased during disease, especially after five and ten years of intervention. TheE.multilocularisantigen (EmAg) inducible cellular productions of MCP1(CCL13), TARC(CCL17) and PARC(CCL18) were lowest in patients with cured AE and infection-free controls, while the EmAg inducible cellular production of IFN-γ increased after cure. Significant positive cytokine and chemokine correlations were observed in AE patients for IL-9, IL-10, CCL13(MCP-4), CCL17(TARC) and CCL20(LARC)(for all p<0.001).E.multilocularisspecific IgG4 response correlated positively with TARC (p<0.001). Both markers enhanced over time in progressive disease and decreased after cure. The levels of IL-8, IL-10, MCP4 and LARC enhanced with AE regression.Conclusions/SignificanceRepeated biomarker surveys are advisable to evaluate progression or regression of disease during longitudinal follow-up and such analyses can support imaging techniques and improve staging of AE patients.
RAVAL trial: Protocol of an international, multi-centered, blinded, randomized controlled trial comparing robotic-assisted versus video-assisted lobectomy for early-stage lung cancer
Authors: Patel Yogita S. , Hanna Waël C. , Fahim Christine , Shargall Yaron , Waddell Thomas K. , Yasufuku Kazuhiro , Machuca Tiago N. , Pipkin Mauricio , Baste Jean-Marc , Xie Feng , Shiwcharan Andrea , Foster Gary , Thabane Lehana 
Published: February 2022

Background
Retrospective data demonstrates that robotic-assisted thoracoscopic surgery provides many benefits, such as decreased postoperative pain, lower mortality, shorter length of stay, shorter chest tube duration, and reductions in the incidence of common postoperative pulmonary complications, when compared to video-assisted thoracoscopic surgery. Despite the potential benefits of robotic surgery, there are two major barriers against its widespread adoption in thoracic surgery: lack of high-quality prospective data, and the perceived higher cost of it. Therefore, in the face of these barriers, a prospective randomized controlled trial comparing robotic- to video-assisted thoracoscopic surgery is needed. The RAVAL trial is a two-phase, international, multi-centered, blinded, parallel, randomized controlled trial that is comparing robotic- to video-assisted lobectomy for early-stage non-small cell lung cancer that has been enrolling patients since 2016.

Methods
The RAVAL trial will be conducted in two phases: Phase A will enroll 186 early-stage non-small cell lung cancer patients who are candidates for minimally invasive pulmonary lobectomy; while Phase B will continue to recruit until 592 patients are enrolled. After consent, participants will be randomized in a 1:1 ratio to either robotic- or video-assisted lobectomy, and blinded to the type of surgery they are allocated to. Health-related quality of life questionnaires will be administered at baseline, postoperative day 1, weeks 3, 7, 12, months 6, 12, 18, 24, and years 3, 4, 5. The primary objective of the RAVAL trial is to determine the difference in patient-reported health-related quality of life outcomes between the robotic- and video-assisted lobectomy groups at 12 weeks. Secondary objectives include determining the differences in cost-effectiveness, and in the 5-year survival data between the two arms. The results of the primary objective will be reported once Phase A has completed accrual and the 12-month follow-ups are completed. The results of the secondary objectives will be reported once Phase B has completed accrual and the 5-year follow-ups are completed.

Discussion
If successfully completed, the RAVAL Trial will have studied patient-reported outcomes, cost-effectiveness, and survival of robotic- versus video-assisted lobectomy in a prospective, randomized, blinded fashion in an international setting.

Trial registration
ClinicalTrials.gov, NCT02617186. Registered 22-September-2015. https://clinicaltrials.gov/ct2/show/NCT02617186
Detection of SARS-CoV-2 infection prevalence in 860 cancer patients with a combined screening procedure including triage, molecular nasopharyngeal swabs and rapid serological test. A report from the first epidemic wave
Authors: Candoni Anna , Petruzzellis Giuseppe , Sperotto Alessandra , Andreotti Victoria , Giavarra Marco , Corvaja Carla , Minisini Alessandro , Comuzzi Chiara , Tascini Carlo , Fanin Renato , Fasola Gianpiero 
Published: February 2022

Introduction
Even if now we have available the weapon of vaccination against SARS-CoV-2, the patients with cancer remains a very frail population in which frequently the immunologic response to vaccination may be impaired. In this setting, the SARS-CoV-2 infection screening retains a great value. However, there are still limited data on the feasibility and efficacy of combined screening procedures to assess the prevalence of SARS-CoV-2 infection (including asymptomatic cases) in cancer outpatients undergoing antineoplastic therapy.

Patients and results
From May 1, 2020, to June 15, 2020, during the first wave of SARS-CoV-2 pandemic, 860 consecutive patients, undergoing active anticancer therapy, were evaluated and tested for SARS-CoV-2 with a combined screening procedure, including a self-report questionnaire, a molecular nasopharyngeal swab (NPS) and a rapid serological immunoassay (for anti-SARS-CoV-2 IgG/IgM antibodies). The primary endpoint of the study was to estimate the prevalence of SARS-CoV-2 infection (including asymptomatic cases) in consecutive and unselected cancer outpatients by a combined screening modality. A total of 2955 SARS-CoV-2 NPS and 860 serological tests, in 475 patients with hematologic cancers and in 386 with solid tumors, were performed. A total of 112 (13%) patients self-reported symptoms potentially COVID-19 related. In 1/860 cases (< 1%) SARS-CoV-2 NPS was positive and in 14 cases (1.62%) the specific serological test was positive (overall prevalence of SARS-CoV-2 infection 1.62%). Of the 112 cases who declared symptoms potentially COVID-19-related, only 2.7% (3/112) were found SARS-CoV-2 positive.

Conclusions
This is the largest study reporting the feasibility of a combined screening procedure (including triage, NPS and serologic test) to evaluate the prevalence of SARS-CoV-2 infection in cancer patients receiving active therapy, during the first epidemic wave and under the restrictive lockdown measures, in one of the active areas of the SARS-CoV-2 circulation. Lacking specific recommendations for the detection of asymptomatic SARS-CoV-2 cases, a combined diagnostic screening might be more effective to detect the exact prevalence of SARS-CoV-2 in neoplastic patient population. The prevalence can obviously change according to the territorial context, the entity of the restrictive measures adopted and the phase of the epidemic curve. However, its exact and real-time knowledge could be important to balance risks/benefits of oncologic treatments, avoiding (if the prevalence is low) the reduction of dose intensity or the selection of less intensive (but also less effective) anti-cancer therapies.
What are the trends in seeking health care for fever in children under-five in Sierra Leone? evidence from four population-based studies before and after the free health care initiative
Authors: Bognini Joel Dofinissery , Samadoulougou Sekou , Ouedraogo Mady , Smart Francis , Kankoye David Tiga , Sankoh Osman , Kirakoya-Samadoulougou Fati 
Published: February 2022

Background
In 2010, the government of Sierra Leone implemented the Free Health Care Initiative (FHCI) in the country with the objective of reducing the high maternal, infant, and child mortality rates and improving general health indicators. The objective of this study was to assess the trends in the prevalence of health care-seeking and to identify the determinants of healthcare service utilization by caregivers of children younger than five years.

Methods
The analysis of health-care-seeking behavior was done using data from four population-based surveys in Sierra Leone before (2008) and after (2013, 2016, 2019) the FHCI was implemented. Care-seeking behavior was assessed with regard to caregivers seeking care for children under-five in the two weeks prior to each survey. We compared the percentages of healthcare-seeking behavior change and identify factors associated with healthcare-seeking using a modified Poisson regression model with generalized estimating equations.

Results
In 2008, a total of 1208 children with fever were recorded, compared with 2823 children in 2013, 1633 in 2016, and 1464 in 2019. Care-seeking for children with fever was lowest in 2008 (51%; 95% CI (46.4−55.5)) than in 2013 (71.5%; 95% CI (68.4−74.5)), 2016 (70.3%; 95% CI (66.6−73.8)), and 2019 (74.6%; 95% CI (71.6−77.3)) (p < 0.001). Care-seeking in 2013, 2016 and 2019 was at least 1.4 time higher than in 2008 (p < 0.001) after adjusting for mother’s age, wealth, religion, education level, household head and the child’s age. Care-seeking was lowest for children older than 12 months, mothers older than 35 years, children living in the poorest households, and in the northern region. A trend was observed for the sex of the household head. The level of care-seeking was lowest when the household head was a man.

Conclusions
The increase in healthcare-seeking for children under-five with fever followed the introduction of the FHCI in Sierra Leone. Care-seeking for fever varied by the child’s age, caregiver’s age, household wealth, the sex of the household head and region. Maintaining the FHCI with adequate strategies to address other barriers beyond financial ones is essential to reduce disparities between age groups, regions and, households.
Immunogenicity of BNT162b2, BBIBP-CorV and Gam-COVID-Vac vaccines and immunity after natural SARS-CoV-2 infection—A comparative study from Novi Sad, Serbia
Authors: Petrović Vladimir , Vuković Vladimir , Patić Aleksandra , Marković Miloš , Ristić Mioljub 
Published: February 2022

Background
Mass vaccination is the key element in controlling current COVID-19 pandemic. Studies comparing immunogenicity of different COVID-19 vaccines are largely lacking. We aimed at measuring anti-S antibody (Ab) levels in individuals fully vaccinated with BNT162b2, BBIBP-CorV and Gam-COVID-Vac, as well as in COVID-19 convalescents.

Methods
In this cross-sectional study, serum was collected from 400 age- and sex-matched participants, 100 fully vaccinated with BNT162b2, 100 with BBIBP-CorV and 100 with Gam-COVID-Vac on the 28th day after the second vaccine dose, and 100 recovered from COVID-19 at least 28 days after symptom(s) resolution. Sera were analyzed using the LIAISON SARS-CoV-2 S1/S2 IgG assay (DiaSorin, Saluggia, Italy). Wilcoxon rank-sum or Kruskal–Wallis tests was used for comparison of Ab levels.

Results
Highest mean value (210.11, SD = 100.42) was measured in the BNT162b2 group, followed by Gam-COVID-Vac (171.11, SD = 120.69) and BBIBP-CorV (68.50, SD = 72.78) AU/mL (p<0.001). Significant differences in antibody levels were found between BNT162b2 and BBIBP-CorV (p<0.001), BNT162b2 and Gam-COVID-Vac (p = 0.001), as well as BBIBP-CorV and Gam-COVID-Vac groups (p<0.001). Percentage of seropositive was 81% in the convalescent group, 83% in BBIBP-CorV vaccinated and 100% in BNT162b2 and Gam-COVID-Vac. When comparing measured antibody levels in vaccinated to those in COVID-19 recovered, significantly higher antibody levels were found for vaccinated with BNT162b2 (p<0.001), and with Gam-COVID-Vac (p<0.001), while for BBIBP-CorV there was no statistically significant difference (p = 0.641).

Conclusions
All three investigated vaccines, BNT162b2, BBIBP-CorV and Gam-COVID-Vac, provide robust immune response 28 days after the second dose of vaccine, in the majority of participants. All individuals vaccinated with BNT162b2 and Gam-COVID-Vac seroconverted, while in vaccinated with BBIBP-CorV and COVID-19 recovered seroconversion rates were lower. Although less potent compared to other two vaccines, immune response after BBIBP-CorV was similar to response measured in convalescents. Challenge still remains to examine dynamics and durability of immunoprotection.
Zer dela-eta zahartzen gara?
Authors: Revuelta Miren , Moreno-Cugnon Leire , Matheu Ander 
Published: February 2022

Zahartzea izaki bizidun guztietan gertatzen den prozesu natural bat da, denbora igarotzearen ondoriozko gainbehera funtzional bezala defini daitekeena. Gaur egun, hainbat hipotesi proposatu dira zahartzearen zergatia azaltzeko, horien artean aurkitzen da zelula amen agortzearen ikerketa lerroa. Zelula amak, berritze gaitasuna dutenak eta ondorengo zelula diferentziatuak sortzeko gai direnak, zahartzaroarekin kopuruz murrizten doaz. Zehazki, zahartzaroak fisiologikoki gehien kaltetzen duen organoa garuna da, eta adinak eragindako garuneko zelula amen agortze honek neuronen berritzea zailtzen du, indibiduo helduetan ikus dezakegun gainbehera kognitiboa eraginez. Neurogenesia garuneko zonalde espezifikoetan gertatzen da, bentrikulu beheko zonaldean eta hipokanpoko granulu beheko zonaldean eta azken ikerketen arabera bai haurtzaroan zein zahartzaroan gertatzen den prozesu bat da. Beraz oso garrantzitsua da zahartzaroan zehar zelula ama hauen funtzioa nola mantendu daitekeen ikertzea alderdi kognitiboan emandako aldaketa hauek ekiditeko.
El Poder Local y la Modernización Autoritaria en Granada.
Authors: Hidalgo Álvarez Roque , Morente Muñoz Carmen , Pérez Serrano Julio 
Published: February 2022

Después de cinco años de administración local bajo la presidencia del marqués de Casablanca ninguno de los proyectos de modernización de Granada había comenzado. El alcalde-presidente se negó a solicitar empréstitos a entidades bancarias. Tras su dimisión un nuevo Ayuntamiento presidido por el abogado Mariano Fernández Sánchez-Puerta fue cooptado por el Directorio Civil para ejecutar los proyectos. Las prioridades fueron el alcantarillado, el agua potable, el ensanche de la ciudad y la construcción de un Camino de Ronda. El coste de la modernización se estimó en treinta y dos millones y medio de pesetas, incluyendo los dieciséis y medio del proyecto prioritario del alcantarillado y aguas potables. Tanto en la operación del empréstito como en la adjudicación de la contrata se aceptó la oferta más barata que pronto se demostró inviable. La modernización autoritaria impulsada por el Ayuntamiento no alcanzó ninguno de sus objetivos iniciales y resultó un rotundo fracaso
Psicologia Escolar, políticas educacionais e os impactos da pandemia de Covid-19: reflexões a partir do enfoque histórico-cultural
Authors: Souza Marilene Proença Rebello de 
Published: February 2022

Este artigo discute as políticas públicas de educação no Brasil e o papel da psicologia escolar e educacional tomando como fundamento a Psicologia Histórico-cultural no contexto da Pandemia de Covid-19. Apresenta brevemente os grandes desafios da educação básica centrados nas questões históricas de exclusão da e na escola e os processos de agravamento da desigualdade social com consequências para a escolarização. Sugere propostas para o enfrentamento em situações de crise por meio de ações que sejam interdisciplinares, multiprofissionais e intersetoriais, tais como: a) realizar um diagnóstico geral da situação escolar, baseando-se nos dados possíveis sobre a região, sobre as famílias e os estudantes, podendo realizar atividades que possibilitem conhecer mais de perto as dificuldades e possibilidades de acesso ao conhecimento e às necessidades sociais e econômicas apresentadas; b) repensar os espaços de convivência, as formas de estabelecer os currículos, de incentivar a participação de todos os segmentos da escola; c) viabilizar projetos coletivos, ações e estratégias que tenham as pessoas como protagonistas de suas histórias, trajetórias e dores que foram marcas dessa pandemia. Reafirma, por fim, o papel que vem desempenhando a Teoria Histórico-Cultural no processo de discussão de temáticas centrais para a educação básica, considerando o contexto social, político, econômico e cultural bem como os processos de subjetivação que constituem a humanização.