bluuebunny/crossref_metadata_2025_split huggingface dataset:
Matching Logic Based on Ownership Transfer
Authors: Wang Shangbei , Wang Yintong 
Published: November 2022

We combine “ownership transfer” with matching logic to reason about fault-free partial correctness of shared-memory concurrent programs. As we all know, what really gives separation logic (concurrent separation logic) an edge is the ownership transfer of the heap. Inspired by this, we use matching logic to realize variable ownership (permission) and its transfer mechanism, which reveals the hidden principle behind “protected variables” of resource and “rely set” in extended CSL. In addition, variable ownership can replace Dijkstra’s semaphore blocking technique to achieve the critical section. Soundness is important to us, we provide a semantic model that supports the separation property and demonstrate the soundness of our logic based on trace semantics.
First Randomized, Multicenter, Placebo-Controlled Study of Self-Administered Intranasal Etripamil for Acute Conversion of Spontaneous Paroxysmal Supraventricular Tachycardia (NODE-301)
Authors: Stambler Bruce S. , Plat Francis , Sager Philip T. , Shardonofsky Silvia , Wight Douglas , Potvin Diane , Pandey A. Shekhar , Ip James E. , Coutu Benoit , Mondésert Blandine , Sterns Laurence D. , Bennett Matthew , Anderson Jeffrey L. , Damle Roger , Haberman Ronald , Camm A. John 
Published: November 2022

Background:
Pharmacologic termination of paroxysmal supraventricular tachycardia (PSVT) often requires medically supervised intervention. Intranasal etripamil, is an investigational fast-acting, nondihydropyridine, L-type calcium channel blocker, designed for unsupervised self-administration to terminate atrioventricular nodal–dependent PSVT. Phase 2 results showed potential safety and efficacy of etripamil in 104 patients with PSVT.

Methods:
NODE-301, a phase 3, multicenter, double-blind, placebo-controlled study evaluated the efficacy and safety of etripamil nasal spray administered, unsupervised in patients with symptomatic sustained PSVT. After a medically supervised etripamil test dose while in sinus rhythm, patients were randomized 2:1 to receive etripamil 70 mg or placebo. When PSVT symptoms developed, patients applied a cardiac monitor and attempted a vagal maneuver; if symptoms persisted, they self-administered blinded treatment. An independent Adjudication Committee reviewed continuous electrocardiogram recordings. The primary efficacy endpoint was termination of adjudicated PSVT within 5 hours after study drug administration.

Results:

NODE-301 accrued 156 positively adjudicated PSVT events treated with etripamil (n=107) or placebo (n=49). The hazard ratio for the primary endpoint, time-to-conversion to sinus rhythm during the 5-hour observation period, was 1.086 (95% CI, 0.726–1.623;
P
=0.12). In predefined sensitivity analyses, etripamil effects (compared with placebo) occurred at 3, 5, 10, 20, and 30 minutes (
P
<0.05). For example, at 30 minutes, there was a 53.7% of SVT conversion in the treatment arm compared to 34.7% in the placebo arm (hazard ratio, 1.87 [95% CI, 1.09–3.22];
P
=0.02). Etripamil was well tolerated; adverse events were mainly related to transient nasal discomfort and congestion (19.6% and 8.0%, respectively, of randomized treatment-emergent adverse events.

Conclusions:
Although the primary 5-hour efficacy endpoint was not met, analyses at earlier time points indicated an etripamil treatment effect in terminating PSVT. Etripamil self-administration during PSVT was safe and well tolerated. These results support continued clinical development of etripamil nasal spray for self-administration during PSVT in a medically unsupervised setting.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03464019.
The Influence of the Dimensions of Perceived Value on Keepers’ Satisfaction and Intention to Abandon
Authors: Luna-Cortés Gonzalo 
Published: November 2022

Abstract
This research examines the effect of dimensions of keepers’ perceived value (utilitarian, emotional, social) of their dogs on the dogs’ behavioral problems, keepers’ satisfaction, and intent to abandon their dogs, using confirmatory factor analysis (CFA) and structural equation modeling (SEM). A questionnaire was administered to 330 keepers walking their dogs in a national park in Bogotá, Colombia, which examined their perceptions of and attitudes toward their dogs. Keepers who placed a higher utilitarian value on their dog were more satisfied with their dog. Positive feelings toward their dogs (emotional value) negatively affected the keepers’ intention to abandon their dogs. Contrary to prior findings, the social value of dogs did not influence dogs’ behavioral problems. Finally, as expected, dogs’ behavioral problems negatively influenced keepers’ satisfaction, which affected keepers’ intention to abandon their dogs. Theoretical and practical implications of the dimensions of perceived value in the field of dogs’ welfare are discussed.
Description and molecular characterisation of Ditylenchus pedrami n. sp. (Rhabditida: Anguinidae) from Iran
Authors: Azimi Sedighe , Abdolkhani Abbas 
Published: November 2022

Summary
Ditylenchus pedrami n. sp., recovered from the rhizospheric soil of date palm in Khuzestan province, southwest Iran, is described and illustrated based upon morphological and molecular data. The new species is characterised by having six lines in the lateral field, lip region smooth and continuous with body contour, stylet 9-11 μm long, median pharyngeal bulb oval with small valve, pharyngeal bulb offset from the intestine, V = 83.9 (80.2-88.1), conoid tail with a pointed, dull or rounded tip and males with 20.1 (17-24) μm long spicules. Morphologically, the new species comes close to D. africanus, D. anchilisposomus, D. australiae, D. clarus, D. clavicaudatus and D. parcevivens, mainly by having shared features like six lines in the lateral fields, stylet length and somewhat similar tail tip. The new species was also compared with D. stenurus and D. sarvarae, two species with close phylogenetic affinities to it. The phylogenetic relationships of the new species with representatives of the family Anguinidae were reconstructed and discussed using partial sequences of the small subunit, D2-D3 expansion segments of the large subunit, and internal transcribed spacer regions of ribosomal DNA (SSU, LSU D2-D3 and ITS rDNA) based on Bayesian inference (BI).
Of Men and Dogs
Authors: Minov Sergey 
Published: November 2022

Abstract
This article contains the unpublished Syriac text of the Story of the Dog Who Talked. Put down in writing by the West Syrian monk ʿAzīz bar Ṣlīḇā bar Bassūs in the year 1503, the Story is, arguably, the earliest datable specimen of the fairy tale genre of folklore attested in the Syriac language. The text of the Story, published on the basis of manuscript Mardin, Church of the Forty Martyrs, 350, is accompanied by an English translation and discussion.
The Epistemic Responsibilities of Voters: Towards an Assertion-Based Account
Authors: Giavazzi Michele 
Published: November 2022

Abstract
It is often claimed that democratic voters have epistemic responsibilities. However, it is not often specified why voters have such epistemic responsibilities.
In this paper, I contend that voters have epistemic responsibilities because voting is best understood as an act that bears assertoric force. More precisely, voters perform what I call an act of political advocacy whereby, like an asserter who states or affirms that something is the case, they state or affirm that a certain course of political action is the one that should be followed or enacted.
Consequently, the performance of acts of political advocacy such as voting should be understood as bounded by epistemic norms mirroring those binding the act of assertion and yield epistemic responsibilities mirroring the ones required to satisfy these norms.
The Biography of Muḥammad b. Ibrāhīm al-Nuʿmānī
Authors: Rezaei Azadeh 
Published: November 2022

Abstract
Muḥammad b. Ibrāhīm al-Nuʿmānī, al-Kātib, (d. before 360/971) is a venerable Imāmī traditionist for his celebrated work the Kitāb al-ghayba—a compilation of nearly 445 traditions to demonstrate the occultation of the twelfth Imam and his parousia in the last days of history. Although some monographical studies have been done on this author and his work, the biographical questions about the Imāmī community that he came from, the first places from where he started his Ḥadīth study, and the connection between his being kātib by profession and his learning traditions remained unanswered. The present article is an endeavor to present a more complete biography of al-Nuʿmānī. It consists of an examination of the socioreligious milieu of his hometown al-Nuʿmāniyya, the different places that he visited to his teachers, some fragmentary information about his grandson Abū l-Qāsim al-Maghribī, his stay in Aleppo, his works and pupils, and a more plausible date of his death in Aleppo.
Interpersonal stress mediates the relationship between childhood trauma and depressive symptoms: Findings from two culturally different samples
Authors: Fung Hong Wang , Lam Stanley Kam Ki , Chien Wai Tong , Hung Suet Lin , Ling Henry Wai-Hang , Lee Vincent Wan Ping , Wang Edward KS 
Published: November 2022

Objective: Childhood trauma is associated with adulthood depressive symptoms, but very few studies explored potential social and interpersonal mediators behind this association. This study made the first attempt to test the potential mediating effects of interpersonal stress in the associations between childhood betrayal and non-betrayal trauma and depressive symptoms. Method: We analyzed data in a sample of English-speaking adults from diverse backgrounds (from 19 different countries, mainly from Western countries) ( N = 468). We then replicated and compared the results with those in another convenience sample of Chinese-speaking younger adults with different cultural backgrounds and mental health status ( N = 205). Results: The results in both samples indicated that (1) childhood betrayal trauma had a stronger relationship with depressive symptoms than childhood non-betrayal trauma and that (2) interpersonal stress was a significant mediator in the relationship between childhood betrayal trauma and depressive symptoms, even when childhood non-betrayal trauma was included as a covariate. The indirect effect of childhood non-betrayal trauma on depressive symptoms through interpersonal stress was not consistent in two samples. Conclusions: Our findings point to the importance of taking social and interpersonal contexts into account when investigating, preventing and managing depression in trauma-exposed populations. Early social interventions such as family interventions, interpersonal skills training and building social resources may have the potential to change the trajectory of the development of mental health problems in trauma survivors.
Maximizing Probable Oil Field Profit: Uncertainties on Well Spacing
Authors: MacKay J.A. , Lerche I. 
Published: November 2022

The influence of uncertainties in field development costs, well costs, lifting costs, selling price, discount factor, and oil field reserves are evaluated for their impact on assessing probable ranges of uncertainty on present day worth PDW, oilfield lifetime τ2/3, optimum number of wells OWI, and the minimum (n-) and maximum (n+) number of wells to produce a PDW ≥ 0. The relative importance of different factors in contributing to the uncertainties in PDW, τ2/3, OWI, n- and n+ is also analyzed. Numerical illustrations indicate how the maximum PDW depends on the ranges of parameter values, drawn from probability distributions using Monte Carlo simulations. In addition, the procedure illustrates the relative importance of contributions of individual factors to the total uncertainty, so that one can assess where to place effort to improve ranges of uncertainty; while the volatility of each estimate allows one to determine when such effort is needful.
Utility of combined gadoxetic acid and ferumoxytol-enhanced liver MRI for preoperative detection of colorectal cancer liver metastases: a pilot study
Authors: Carney Benjamin W , Gholami Sepideh , Fananapazir Ghaneh , Sekhon Simran , Lamba Ramit , Loehfelm Thomas W , Wilson Machelle D , Corwin Michael T 
Published: November 2022

Background Colorectal cancer (CRC) is the second-leading cause of cancer-related death worldwide and resection of CRC metastases confined to the liver is the treatment of choice when feasible. Ferumoxytol is an off-label contrast agent that opacifies vasculature and may be helpful in distinguishing metastases from small hemangiomas and blood vessels on gadoxetic acid-enhanced magnetic resonance imaging (MRI). Purpose To compare the diagnostic accuracy of MRI using a standard gadoxetic acid protocol and a combined gadoxetic acid/ferumoxytol protocol in patients with suspected colorectal hepatic metastases. Material and Methods In this institutional review board-approved, single-institution, retrospective study, eight patients underwent gadoxetic acid-enhanced liver MRI, supplemented with additional T1-weighted ferumoxytol enhanced sequences. Two radiologists in consensus identified all metastases using all available sequences, which served as the reference standard. Two different radiologists reviewed each exam twice, once using the standard protocol and once with additional ferumoxytol sequences. The detection rate was estimated as the predicted probability of a metastasis along with the 95% confidence interval (CI) using hierarchical logistic regression models. Results A total of 49 metastases were identified. The mean diameter was 10 mm, measured in greatest axial dimension (median=7 mm; range=2–70 mm). Readers 1 and 2 had detection rates of 69.6% (95% CI = 48.2–85.0) and 53.1% (95% CI = 35.2–70.3) for gadoxetic acid alone and 98.0% (95% CI = 86.3–99.7) and 83.5% (95% CI = 59.3–94.7) for combined protocol. Conclusion In this preliminary investigation, adding ferumoxytol-enhanced sequences to gadoxetic acid liver MRI protocol increased the detection rate of CRC hepatic metastases and may aid in preoperative decision making.
Ultrasound-guided perineal laser ablation versus prostatic arterial embolization for benign prostatic hyperplasia: two similar short-term efficacies
Authors: Cai Huaijie , Zhu Conghui , Fang Jianhua 
Published: November 2022

Background There are many ways to treat prostatic hyperplasia; these are currently more inclined to minimally invasive treatment. We mainly compared the differences between two treatment methods， ultrasound-guided transperineal laser ablation (US-TPLA) and prostatic artery embolization (PAE). Purpose To evaluate the efficacy and safety of US-TPLA and PAE in the treatment of benign prostatic hyperplasia (BPH). Material and Methods The clinical information for 40 patients with BPH admitted to our hospital between June 2018 and January 2021 were retrospectively analyzed. The changes in International Prostate Symptom Score (IPSS), quality of life (QoL), maximum urinary flow rate (Qmax), postvoid residual (PVR), prostate volume (PV), and the incidence of complications were compared between groups. Results The IPSS ( P < 0.001; P < 0.001), QoL ( P < 0.001; P < 0.001), Qmax ( P < 0.001; P < 0.001), PVR ( P < 0.001; P < 0.001), and PV ( P < 0.001; P < 0.001) at three and six months after US-TPLA and PAE improved with respect to those before surgery. There was no significant difference in IPSS ( P = 0.235; P = 0.151), QoL ( P = 0.527; P = 0.294), Qmax ( P = 0.776; P = 0.420), PVR ( P = 0.745; P = 0.607), and PV ( P = 0.527; P = 0.573) between the groups at three and six months after surgery. No serious complications occurred in either group. Conclusion US-TPLA and PAE seem to have a similar short-term efficacy. The efficacy of the two procedures is comparable, and neither is associated with serious complications. US-TPLA and PAE are both effective complementary measures for the treatment of BPH.
Laparoscopic natural orifice specimen extraction, a minimally invasive surgical technique for mid-rectal cancers: Retrospective single-center analysis and single-surgeon experience of selected patients
Authors: Muhammad Shan , Gao YiBo , Guan Xu , QingChao Tang , Fei Shao , Wang Guiyu , Chen Yinggang , Liu Zheng , Jiang Zheng , Kaur Kavanjit , Tatiana Kamchedalova , Ul Ain Qurat , Wang Xishan , He Jie 
Published: November 2022

Objective To evaluate the feasibility, safety, and short-term outcomes of middle rectal resection followed by transanal specimen extraction. Methods Forty-four patients with small mid-rectal tumors underwent laparoscopic rectal resection followed by transanal specimen extraction. Results The procedure was successful in all patients without intraoperative conversion or additional access. The mean operation time was 182.7 minutes (range, 130–255 minutes), the mean blood loss was 26.5 mL (range, 5–120 mL), the mean postoperative exhaust time was 31.3 hours (range, 16–60 hours), and the mean length of hospital stay was 9.5 days (range, 8–19 days). One patient developed anastomotic leakage, which was treated by intravenous antibiotics and daily pelvic cavity flushes through the abdominal drainage tube. No infection-related complications or anal incontinence were observed. The mean tumor size was 2.1 cm (range, 1.6–3.2 cm), the mean number of harvested lymph nodes was 16.5 (range, 6–31), and the mean follow-up time was 8.5 months (range, 2–16 months). By the last follow-up, no signs of recurrence had been found in any patient. Conclusion The combination of standard laparoscopic proctectomy and transanal specimen extraction could become a well-established strategy for selected patients.
The metabolic phenotype of the patient influences the reduction in carotid intima-media thickness achieved following metabolic surgery
Authors: Melchor-López Alberto , Suárez-Cuenca Juan Antonio , Banderas-Lares Diana Zaineff , De la Peña-Sosa Gustavo , Salamanca-García Moisés , Vera-Gómez Eduardo , Hernández-Patricio Alejandro , Gutiérrez-Buendía Juan Ariel , Zamora-Alemán Carlos Ramiro , Alcaráz-Estrada Sofía Lizeth , Ortiz-Fernández Moisés , Montoya-Ramírez Jesús , Felipe Gaytán-Fuentes Omar , Escamilla-Tilch Mónica , Pineda-Juárez Juan Antonio , Antonio Téllez-González Mario , Rodríguez-Arellano Martha Eunice , Contreras-Ramos Alejandra , Hernández-Muñoz Rolando Efraín , Gutiérrez-Salinas José , García Silvia , Mondragón-Terán Paul 
Published: November 2022

Objectives To determine whether metabolic phenotype is associated with the change in carotid intima-media thickness (CIMT) in patients undergoing bariatric /metabolic surgery (BMS). Methods We performed a case-control study of BMS candidates who had metabolically unhealthy obesity (MUO) or metabolically healthy obesity (MHO). We measured the change in CIMT during the 9 months following BMS. The plasma tumor necrosis factor-α, interleukin-1β, adiponectin, leptin, nitric oxide (NO), vascular endothelial growth factor A (VEGF-A), and malondialdehyde concentrations were determined, adipocyte area was measured histologically, and adipose tissue area was estimated using computed tomography. Results Fifty-six patients (mean age 44.5 years, mean body mass index 44.9 kg/m2, 53% women, and 53% had MUO) were studied. Nine months following BMS, the MUO phenotype was not associated with a significant reduction in CIMT, and that of the MHO group was larger. In addition, fewer participants achieved a 10% reduction in CIMT in the MUO group. A CIMT reduction was associated with lower VEGF-A and NO in the MUO group, while that in the MHO group was associated with a higher NO concentration. Conclusion The metabolic phenotype of patients may influence their change in CIMT following BMS, probably through circulating vasodilatory and pro-inflammatory molecules.
The Impact of Trade Openness and FDI on Nigeria’s Economic Growth: Revisiting the Unsettled Debate
Authors: Ari Yılmaz Onur , Jibir Adamu , Hassan Aisha Adamu 
Published: November 2022

The association between trade openness, foreign direct investment (FDI) and economic growth has been thoroughly researched, producing contradictory and unsettled findings. The main reason behind such mixed results may be the lack of capital stock and labour force in the growth–trade relationship. In this study, we re-examine the impact of trade openness and FDI on economic growth. Hence, we used annual time series data for the period of 1996–2019. We evaluate the robustness of our findings by using more than one index of trade openness and by controlling relevant variables that are found significant in growth literature. The Autoregressive Distributed Lag (ARDL) model is used in this article. The results indicate that FDI and capital stock are linked to economic growth in the short and long term. Trade openness, on the other hand, has a negative impact not only on short-term but also on long-term growth. Furthermore, we discovered corruption, inflation and labour force to have significant negative association with economic growth. This connotes that openness to capital flows is more important to the Nigerian economy than trade openness. Thus, if complementary strategies are implemented, the negative association between economic growth and trade openness may be significantly reversed. These results, therefore, suggest the promotion of policies that support improvement in capital formation by private, public and foreign investors. JEL Classification C13, F10, F43, N17, O40
A Universal Device to Convert a Continuous Flow Assist Device to a Pulsatile Flow Device to Simulate Normal Blood Flow and Pressure Patterns
Authors: Gerrah Rabin 
Published: November 2022

Background Continuous follow assist devices (CFAD) are the most commonly used mechanical circulatory support devices. Compared to Pulsatile flow assist devices (PFAD), CFADs deliver a non-physiologic type of flow, which might contribute to complications related to lack of pulsatility in these devices. Moreover, lack of pulsatility complicates the clinical management of these patients who often present with good perfusion but with no palpable pulse and none or a negligible pulse pressure on blood pressure measurement. Methods and results Presented here is a concept of a universal converter device that can be added inline other CFADs to convert the flow from continuous to pulsatile, simulating a normal flow and pressure pattern. After initial implantation and stabilization with a CFAD, adding this converter might potentially provide the benefits of pulsatile physiologic flow. The device is made of 2 components connected in parallel, working in tandem in user determined cycles. The continuous flow through a specifically positioned openings create a smooth conversion to a pulsatile flow. This device can convert a continuous flow to a physiologic pulsatile flow to achieve a native-like flow pattern and potentially prevent some CFAD complications. Conclusion This paper presents the concept of pulsatility generation and simulation for other assist devices. Such a device can be a universal add-on or a supplemental option for CFADs.
Large thrombus in non-atherosclerotic thoracic ascending aorta as the source of acute upper limb ischemia in a young cocaine user
Authors: Lojo-Lendoiro Sara , Calvin-Álvarez Pablo , Mosquera-Barreiro Marta 
Published: November 2022

Objectives We present the case of a young woman cocaine user without other cardiovascular risk factors attended to the emergency service presenting signs of acute arterial ischemia on the right arm. Methods An angio-CT of the upper limb was performed, highlighting the occlusion of the radial and ulnar arteries and in addition revealed a floating thrombus in the posterior wall of the aortic arch. Results The patient underwent urgent surgery with transhumeral thrombectomy and four days later, she underwent surgery to remove the aortic thrombus. Conclusions A floating thrombus in a non-atherosclerotic ascending aorta conditioning peripheral embolism with upper limbs ischemia is a very rare entity that has to be evaluated finding and treating the origin of the pathology.