bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic investigation reveals that Ishihara et al.’s (2008) STEARC effect only emerges when time is directly assessed
Authors: Mariconda Alberto , Prpic Valter , Mingolo Serena , Sors Fabrizio , Agostini Tiziano , Murgia Mauro 
Published: November 2022

AbstractThe Spatial–TEmporal Association of Response Codes (STEARC) effect (Ishihara et al. in Cortex 44:454–461, 2008) is evidence that time is spatially coded along the horizontal axis. It consists in faster left-hand responses to early onset timing and faster right-hand responses to late onset timing. This effect has only been established using tasks that directly required to assess onset timing, while no studies investigated whether this association occurs automatically in the auditory modality. The current study investigated the occurrence of the STEARC effect by using a procedure similar to Ishihara and colleagues. Experiment 1 was a conceptual replication of the original study, in which participants directly discriminated the onset timing (early vs. late) of a target sound after listening to a sequence of auditory clicks. This experiment successfully replicated the STEARC effect and revealed that the onset timing is mapped categorically. In Experiments 2, 3a and 3b participants were asked to discriminate the timbre of the stimuli instead of directly assessing the onset timing. In these experiments, no STEARC effect was observed. This suggests that the auditory STEARC effect is only elicited when time is explicitly processed, thus questioning the automaticity of this phenomenon.
The g3mclass is a practical software for multiclass classification on biomarkers
Authors: Guvakova Marina A. , Sokol Serguei 
Published: November 2022

AbstractThe analytes qualified as biomarkers are potent tools to diagnose various diseases, monitor therapy responses, and design therapeutic interventions. The early assessment of the diverseness of human disease is essential for the speedy and cost-efficient implementation of personalized medicine. We developedg3mclass, the Gaussian mixture modeling software for molecular assay data classification. This software automates the validated multiclass classifier applicable to single analyte tests and multiplexing assays. Theg3mclassachieves automation using the original semi-constrained expectation–maximization (EM) algorithm that allows inference from the test, control, and query data that human experts cannot interpret. In this study, we used real-world clinical data and gene expression datasets (ERBB2, ESR1, PGR) to provide examples of howg3mclassmay help overcome the problems of over-/underdiagnosis and equivocal results in diagnostic tests for breast cancer. We showed theg3mclassoutput’s accuracy, robustness, scalability, and interpretability. The user-friendly interface and free dissemination of this multi-platform software aim to ease its use by research laboratories, biomedical pharma, companion diagnostic developers, and healthcare regulators. Furthermore, theg3mclassautomatic extracting information through probabilistic modeling is adaptable for blending with machine learning and artificial intelligence.
The valance state of vanadium-key factor in the flexibility of potassium vanadates structure as cathode materials in Li-ion batteries
Authors: Prześniak-Welenc M. , Nadolska M. , Jurak K. , Li J. , Górnicka K. , Mielewczyk-Gryń A. , Rutkowska M. , Nowak A. P. 
Published: November 2022

AbstractPotassium hexavanadate (K2V6O16·nH2O) nanobelts have been synthesized by the LPE-IonEx method, which is dedicated to synthesis of transition metal oxide bronzes with controlled morphology and structure. The electrochemical performance of K2V6O16·nH2O as a cathode material for lithium-ion batteries has been evaluated. The KVO nanobelts demonstrated a high discharge capacity of 260 mAh g−1, and long-term cyclic stability up to 100 cycles at 1 A g−1. The effect of the vanadium valence state and unusual construction of the nanobelts, composed of crystalline and amorphous domains arranged alternately were also discussed in this work. The ex-situ measurements of discharged electrode materials by XRD, MP-AES, XAS and XPS show that during the subsequent charge/discharge cycle the potassium in the K2V6O16·nH2O structure are replacing by lithium. The structural stability of the potassium hexavandate during cycling depends on the initial vanadium valence state on the sample surface and the presence of the “fringe free” domains in the K2V6O16·nH2O nanobelts.
Reconfigurable broadband metasurfaces with nearly perfect absorption and high efficiency polarization conversion in THz range
Authors: Nguyen Thi Minh , Vu Dinh Lam , Nguyen Thi Quynh Hoa , Kim Jung-Mu 
Published: November 2022

AbstractReconfigurable metasurfaces (RMSs) that enable the switching function of absorption and polarization conversion have attracted increasing attention. However, the design of RMSs to achieve wideband and high efficiency for both absorption and polarization conversion functions simultaneously remains a great challenge. Here, we propose the design of a RMS structure with a high-efficiency cross-polarization conversion and nearly perfect absorption. The reconfiguration between different functions of polarization conversion and absorption is obtained based on the reversible insulator-to-metal phase transition of Vanadium dioxide (VO$$_{2}$$

2

). When the VO$$_{2}$$

2

is in insulator state, the RMS realizes the cross-polarization conversion function in the wideband of 1.04–3.75 THz with a relative bandwidth up to 113 $$\%$$
%
due to the multi-resonant modes of electric and magnetic resonances. Meanwhile, the nearly-perfect absorption is achieved in the range of 1.36–3.38 THz with the corresponding relative bandwidth up to 85 $$\%$$
%
for the VO$$_{2}$$

2

in metallic state. Specially, the wideband and high-efficiency performance of these functionalities is maintained for a wide angle incidence. The capability of bi-functional switch and integration with polarization conversion and absorption in a single metasurface structure endowed with both wideband and high-efficiency characteristics for a wide incident angle is very promising for emerging RMS devices in the terahertz region.
Testosterone promotion effect of Eucommia ulmoides staminate flower via the steroidogenic pathway and potential hormonal mechanism
Authors: Li Zihan , Yang Ping , Xue Shan , Yuan Shijun , Yuan Lin , Yan Renyi , Tang Ding , Li Juan 
Published: November 2022

AbstractEucommia ulmoides staminate flowers (EUF), a newly approved functional food in China, have great potential for hormonal regulation. Herein, we aim to demonstrate the chemical composition and pharmacological activity of EUF in testosterone production and hormonal regulation. EUF extract and its components, kaempferol and geniposidic acid, exhibited a strong stimulating effect by increasing testosterone secretion, reducing ROS production, or promoting viability in Leydig cells. Meanwhile, the increased testosterone production was related to the upregulation of mRNA and protein expression of the steroidogenic pathway, such as steroidogenic acute-regulatory protein (StAR), 3β -hydroxysteroid dehydrogenase type 1 (HSD3B1), 17α-hydroxylase/17,20-lyase (CYP17A1), and nuclear receptor subfamily 5 group A member 1 (NR5A1). However, PKA inhibitor H89 or adenylyl cyclase inhibitor SQ22536 could block their effect. The results of transgenic yeast models showed the androgenic agonistic effects of kaempferol and naringenin and the estrogenic agonistic effects of rutin. These results indicated that the testosterone promotional effect of EUF was related to the activation of the steroidogenic pathway and potential hormonal regulation. Kaempferol and geniposidic acid might be the key active ingredients.
Physical activity and daily steps cut offs points for overweight/obesity prevention among eight Latin American countries
Authors: Ferrero-Hernández Paloma , Farías-Valenzuela Claudio , Jofré-Saldía Emilio , Marques Adilson , Kovalskys Irina , Gómez Georgina , Rigotti Attilio , Cortés Lilia Yadira , García Martha Yépez , Pareja Rossina G. , Herrera-Cuenca Marianella , Fisberg Mauro , Silva Danilo R. , Sadarangani Kabir P. , Ferrari Gerson 
Published: November 2022

AbstractThis study aims to establish cut-off points for the number of minutes of physical activity intensity and the number of daily steps that identify overweight/obesity in adolescents, adults, and older adults. This study examined data from 2737 participants. Physical activity intensity and the number of daily steps were assessed using GT3X+ ActiGraph model accelerometers. Body mass index, waist-to-height ratio, and waist-to-hip ratio were used as indicators of overweight/obesity. The cut-off points for moderate-to-vigorous physical activity for the prevention of overweight/obesity according to body mass index in women ranged from 15.1 to 30.2 min/day; in men, the values were from 15.4 to 33.8 min/day. The lowest cut-off point for daily steps was established in the adolescent group for women and men (7304 and 5162). The highest value in women was 11,412 (51–65 years) and 13,234 in men (18–30 years). Results from measurements different from BMI, show average cut-off points for moderate-to-vigorous physical activity and daily steps of 29.1/8348 and 43.5/10,456 according to waist-to-height ratio; and results of 29.3/11,900 and 44.3/11,056 according to the waist-to-hip ratio; in women and men respectively. A more specific recommendation of physical activity and daily steps adjusted by sex and age range is suggested to prevent overweight/obesity.
Evaluation of dosimetric characteristics of a ternary nanocomposite based on High Density Polyethylene/Bismuth Oxide/Graphene Oxide for gamma-rays
Authors: Veiskarami Amir , Sardari Dariush , Malekie Shahryar , Mofrad Farshid Babapour , Kashian Sedigheh 
Published: November 2022

AbstractThis research aims to investigate a ternary nanocomposite based on High Density Polyethylene/ Bismuth Oxide/Graphene Oxide (HDPE/Bi2O3/GO) at various concentrations. Solution method was used to fabricate the samples. FESEM-EDX mapping, AFM, TEM, XRD, XPS, FTIR, and TGA/DTG analyses were carried out on the samples. XRD analysis demonstrated a semi-crystalline behavior for the samples. TEM analysis exhibited a cauliflower-like structure of the material. The sample was irradiated by gamma-rays of60Co source over the dose rate of 30–254 mGy/min and the electric current was measured as the response of the real-time dosimeter. Thus, various dosimetric characteristics were performed, namely linearity, angular dependence, energy dependence, bias-polarity, field size, and repeatability of the data. Results showed that response of the dosimeter was linear in the range of the investigated dose rate. The sensitivity of the 60 wt% Bi2O3sample was measured as 3.4 nC·mGy−1. The angular response variation was 20% for normal beam incidence. The response of the dosimeter to assess the energy dependency was obtained as 2.2% at the radiation field of the137Cs and60Co beams. The dosimeter response was dependent on the bias-polarity, with maximum discrepancy of 11.1%. The dosimetry response was highly dependent upon the radiation field size. The repeatability of the dosimeter response was measured with standard deviation less than 1%. As well, the dosimeter response during the one-hour irradiation was stable with a standard deviation of 0.66%. Results showed that considering some correction factors, this material can be used for dosimetry of gamma-rays at the therapy level.
Systems pharmacology approach to investigate the mechanism of Artemisia argyi in treating rheumatic diseases
Authors: Huang Yuanzhi , Jin Xupeng , Liu Jiayi , Wu Wei , Wang Huiping 
Published: November 2022

AbstractArtemisia argyi (AA) has been proven to be effective in the adjuvant treatment of rheumatism (RA), but the mechanism of its action in RA is not clear. This study aims to clarify the molecular mechanism of AA as a potential therapy for RA by using network pharmacology. The TCM systems pharmacology (TCMSP) was used to screen the active components of AA, and identification of the potential target genes of active compounds and rheumatism was performed with PharmMapper and GeneCards, respectively. Construction of complex target networks and protein–protein interaction networks was based on the Cytoscape software. The biological functions and pathway analysis of targets and effective targets were analyzed using DAVID. Our study demonstrated that 105 target genes were associated with these active compounds and RA. ALB, AKT1, and MAPK1 were the first three hub genes, and the metabolic and signaling pathways related to these hub genes were remarkably abundant. Results showed that AA might play a role in RA by affecting multiple targets and multiple ways, reflecting that TCM was characterized by multicomponents and multitargets. AA has the potential to be a promising new candidate for the treatment of RA and has value for further research and development.
Characterization of the plastid genome of Cratoxylum species (Hypericaceae) and new insights into phylogenetic relationships
Authors: Sudmoon Runglawan , Kaewdaungdee Sanit , Tanee Tawatchai , Siripiyasing Pornnarong , Ameamsri Unchaleeporn , Syazwan Samsuddin Ahmad , Lee Shiou Yih , Chaveerach Arunrat 
Published: November 2022

AbstractTo expand the genomic information of Hypericaceae, particularly on Cratoxylum, we characterized seven novel complete plastid genomes (plastomes) of five Cratoxylum and two of its allied taxa, including C. arborescens, C. formosum subsp. formosum, C. formosum subsp. pruniflorum, C. maingayi, C. sumatranum, Hypericum hookerianum, and Triadenum breviflorum. For Cratoxylum, the plastomes ranged from 156,962 to 157,792 bp in length. Genomic structure and gene contents were observed in the five plastomes, and were comprised of 128–129 genes, which includes 83–84 protein-coding (CDS), 37 tRNA, and eight rRNA genes. The plastomes of H. hookerianum and T. breviflorum were 138,260 bp and 167,693 bp, respectively. A total of 110 and 127 genes included 72 and 82 CDS, 34 and 37 tRNA, as well as four and eight rRNA genes. The reconstruction of the phylogenetic trees using maximum likelihood (ML) and Bayesian inference (BI) trees based on the concatenated CDS and internal transcribed spacer (ITS) sequences that were analyzed separately have revealed the same topology structure at genus level; Cratoxylum is monophyletic. However, C. formosum subsp. pruniflorum was not clustered together with its origin, raising doubt that it should be treated as a distinct species, C. pruniflorum based on molecular evidence that was supported by morphological descriptions.
Acute severe hypoxia induces apoptosis of human pluripotent stem cells by a HIF-1α and P53 independent mechanism
Authors: Mucci Sofía , Isaja Luciana , Rodríguez-Varela María Soledad , Ferriol-Laffouillere Sofía Luján , Marazita Mariela , Videla-Richardson Guillermo Agustín , Sevlever Gustavo Emilio , Scassa María Elida , Romorini Leonardo 
Published: November 2022

AbstractHuman embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (hPSCs) that can differentiate into a wide range of specialized cells. Although moderate hypoxia (5% O2) improves hPSC self-renewal, pluripotency, and cell survival, the effect of acute severe hypoxia (1% O2) on hPSC viability is still not fully elucidated. In this sense, we explore the consequences of acute hypoxia on hPSC survival by culturing them under acute (maximum of 24 h) physical severe hypoxia (1% O2). After 24 h of hypoxia, we observed HIF-1α stabilization concomitant with a decrease in cell viability. We also observed an increase in the apoptotic rate (western blot analysis revealed activation of CASPASE-9, CASPASE-3, and PARP cleavage after hypoxia induction). Besides, siRNA-mediated downregulation of HIF-1α and P53 did not significantly alter hPSC apoptosis induced by hypoxia. Finally, the analysis of BCL-2 family protein expression levels disclosed a shift in the balance between pro- and anti-apoptotic proteins (evidenced by an increase in BAX/MCL-1 ratio) caused by hypoxia. We demonstrated that acute physical hypoxia reduced hPSC survival and triggered apoptosis by a HIF-1α and P53 independent mechanism.
Extracellular volume and left ventricular hypertrophy by cardiac magnetic resonance are independent predictors of cardiovascular outcome in obesity
Authors: Lertlaksameewilai Panuwat , Songsangjinda Thammarak , Kaolawanich Yodying , Yindeengam Ahthit , Krittayaphong Rungroj 
Published: November 2022

AbstractThis retrospective cohort study investigated for association between increased extracellular volume (ECV) and left ventricular hypertrophy (LVH) by cardiac magnetic resonance (CMR) and cardiovascular composite outcomes in obesity. Native T1 was measured at the ventricular septum. ECV was calculated from native and post-contrast T1 and hematocrit. Cardiovascular (CV) composite outcomes included acute myocardial infarction, unstable angina requiring hospitalization, myocardial revascularization (excluding early revascularization), heart failure, and CV death. A total of 456 patients with a mean follow-up of 2.1 ± 0.4 years were enrolled. LGE and LVH was detected in 30.5% and 9.2%. 107 patients (23.5%) had the composite outcomes. Multivariable analysis revealed that LGE, LVH, and high ECV as independent predictors for cardiovascular composite outcomes The event rate in the LVH and high ECV, the LVH alone, the high ECV alone, and the no-LVH with lower ECV group was 57.1%, 38.1%, 32.6%, and 17.7%, respectively. Assessment of incremental prognostic value by comparing global chi-square showed that high ECV had additional prognostic value on top of LGE, and LVH. LVH and high ECV are independent predictors of CV composite outcomes in obesity. This is the first study that demonstrate the prognostic value of ECV in obese population.
Abnormal peripheral blood cell counts in neurofibromatosis type 1
Authors: Nobeyama Yoshimasa , Yasuda Ken-ichi , Asahina Akihiko 
Published: November 2022

AbstractNeurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is an autosomal dominant disease characterized by neurofibromas with infiltration of mast cells. Neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR) and basophil-to-lymphocyte ratio (BLR) are examined as markers for various diseases. However, these parameters have not yet been assessed for NF1. This study therefore examined these parameters in NF1 patients. We recruited 153 NF patients (78 males, 75 females) and 51 control patients (31 males, 20 females). Complete blood counts were performed, then NLR, LMR, PLR and BLR were calculated. Neutrophil count was significantly higher in male NF1 patients than in male controls. Lymphocyte count was significantly lower in NF1 patients than in controls for both sexes. Monocyte count was significantly higher in male NF1 patients than in male controls. Basophil count was significantly higher in male NF1 patients than in male controls. NLR, PLR and BLR were significantly higher in NF1 patients than in controls for both sexes. LMR was significantly lower in NF1 patients than in controls for both sexes. NF1 shows high NLR, PLR and BLR and low lymphocyte count and LMR.
Microgravity effect of inter-seismic crustal dilatation
Authors: Kabirzadeh Hojjat , Kim Jeong Woo , Hadi Najafabadi Arezou , Henton Joe , Kao Ricky , Sideris Michael G. 
Published: November 2022

AbstractChanges in the density of the shallow crust has been previously related to co-seismic strain release during earthquakes, however, the influence of inter-seismic deformation on crustal density variations is poorly understood. Here we present gravity observations from the iGrav superconducting gravimeter in southern Vancouver Island, British Columbia, Canada which reveal a substantial gravity increase between July 2012 and April 2015. We identify a negative correlation between this gravity increase and crustal dilatation strain derived from horizontal GPS velocities. The overall increasing gravity trend is caused by the gravity increase during and immediately before and after episodic tremor and slip events, which is partially compensated by gravity decrease occurring between the events. We conclude that the observed gravity increase results from a density increase due to crustal compression and that this is mostly a result of inter-seismic strain accumulation during the subduction of the Juan de Fuca plate beneath the North American plate.
A probabilistic approach for optimal operation of wind‐integrated power systems including UPFC
Authors: Rezaeian‐Marjani Saeed , Jalalat Sajjad Miralizadeh , Tousi Behrouz , Galvani Sadjad , Talavat Vahid 
Published: November 2022

AbstractThe optimal location and setting of the unified power flow controller (UPFC) along with power plant generators' output parameters to enhance power systems reliability in the presence of uncertain variables are determined in this paper. For this purpose, the expected power not served (EPNS) is used as a reliability index based on the total required load shedding at all buses in case of single contingencies such as the outage of lines or generators. The EPNS and components of system's normal operating conditions such as active power losses, voltage deviation index (VDI), as well as economic components, namely, the cost of power generation and UPFC allocation, are taken into consideration in the objective function. The particle swarm optimization (PSO) algorithm optimizes this objective function. Afterward, the firefly algorithm (FA) determines the minimum quantity of required load shedding based on all possible solutions obtained by PSO. Because of the probabilistic nature of loads and renewable generations like wind power generation (WPG), an accurate probabilistic assessment is essential. Therefore, the two‐point estimate method (2PEM) is used, and its performance is compared with the Latin hypercube sampling (LHS) method. The proposed solution method is evaluated on the IEEE 14‐bus and the IEEE 57‐bus test systems and results are discussed.
A real‐time fine echo generation method of extended false target with radially high‐speed moving
Authors: Lei Wei , Zhang Yue , Chen Zengping 
Published: November 2022

AbstractThe false‐target echo generation to Inverse Synthetic Aperture Radar (ISAR) is significant in jamming the enemy ISAR and promoting ISAR development. Generally, it requires false‐target echo coherent with the radar, real time and fine. However, conventional methods, such as digital image synthesizer (DIS), cannot meet those requirements. Moreover, existing methods do not consider the target's radial moving. To meet those demands, we propose an improved method in this study. We equivalently model echo formation as the synthesizer of two independent parts: (1) echo of remote target with radial moving and (2) echo of nearby extended target. In part one, accuracy is improved by utilising the Inner Pulse Motion (IPM) model and complexity is simplified by deducing it as a frequency offset modulation. In part two, the fine extended target echo is constructed by using convolution filtering whose resources consumption can be greatly reduced by separating it into an offline stage and a real‐time stage. Our method is verified by algorithm simulations and actual experiments. The results indicate that it can build the fine false‐target echo in real‐time and can adapt to the target's radial velocity, different resolution and size. Compared with the conventional DIS method, our method reduces the computational complexity significantly and has more comprehensive functions.