bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pan-cancer analysis reveals DDX21 as a potential biomarker for the prognosis of multiple tumor types
Authors: Hu Ankang , Wang Yonghui , Tian Jiahao , Chen Zihan , Chen Renjin , Han Xufeng , Chen Yang , Liu Tingjun , Chen Quangang 
Published: November 2022

BackgroundDExD-box helicase 21 (DDX21) is an essential member of the RNA helicase family. DDX21 is involved in the carcinogenesis of various malignancies, but there has been no comprehensive research on its involvement in different types of cancer.MethodThis study used TCGA, CPTAC, GTEx, GEO, FANTOM5, BioGRID, TIMER2, GEPIA2, cBioPortal, STRING, and Metascape databases and Survival ROC software to evaluate DDX21 gene expression, protein expression, immunohistochemistry, gene mutation, immune infiltration, and protein phosphorylation in 33 TCGA tumor types, as well as the prognostic relationship between DDX21 and different tumors, by survival analysis and similar gene enrichment analysis. Furthermore, Cell Counting Kit-8 (CCK-8) and Transwell studies were employed to assess the effect of DDX21 expression on lung adenocarcinoma (LUAD) cell proliferation and migration.ResultThe DDX21 gene was highly expressed in most cancers, and overexpression was associated with poor overall survival (OS) and disease-free survival (DFS). DDX21 mutations were most common in uterine corpus endometrial carcinoma (UCEC; &gt;5%), and DDX21 expression was positively correlated with the degree of infiltration of CAF and CD8+ cells in several tumor types. Numerous genes were co-expressed with DDX21. Gene enrichment analysis revealed close links between DDX21, RNA metabolism, and ribosomal protein production. In vitro analysis of LUAD cells showed that DDX21 expression was positively correlated with cell proliferation and migration capacity, consistent with prior bioinformatics studies.ConclusionsDDX21 is overexpressed in a variety of cancers, and overexpression in some cancers is associated with poor prognosis. Immune infiltration and DDX21-related gene enrichment analyses indicated that DDX21 may affect cancer development through mechanisms that regulate tumor immunity, RNA metabolism, and ribosomal protein synthesis. This pan-cancer study revealed the prognostic value and the oncogenic role of DDX21.
Vacuum-assisted staged omphalocele reduction: A preliminary report
Authors: Nissen Matthias , Romanova Anna , Weigl Elena , Petrikowski Laura , Alrefai Mohamad , Hubertus Jochen 
Published: November 2022

IntroductionOmphalocele represents a rare congenital abdominal wall defect. In giant omphalocele, due to the viscero-abdominal disproportion, gradual reintegration of eviscerated organs is often associated with medical challenges. We report our preliminary experience combining staged gravitational reduction with vacuum (VAC) therapy as a novel approach for treatment of giant omphalocele.Patients and methodsRetrospective chart review of six patients (five females) born between September 2018 and May 2022 who underwent staged reduction of giant omphalocele in conjunction with VAC therapy was conducted. Treatment was performed at two German third-level Pediatric Surgery Departments. Biometric and periprocedural data were assessed. Main outcome measure was the feasibility of VAC therapy for giant omphalocele. Data are reported as median and interquartile range (Q1–Q3).ResultsGestational age was 37 (37–38) weeks, and birth weight was 2700 (2500–3000) g. VAC dressing was changed every 3 (3–4) days until abdominal fascia closure at the age of 9 (3–13) days. Time to first/full oral feeds was 3 (1–5)/20 (12–24) days with a hospital stay of 22 (17–30) days. Follow-up was 8 (5–22) months and complications were of minor extent (none: n = 2; Clavien–Dindo I: n = 3; Clavien–Dindo II: n = 1), comprising a delayed neo-umbilical cord rest separation (n = 2) and/or concomitant neo-umbilical site infection (n = 2) with no repeat surgery.ConclusionIn neonates with giant omphalocele, VAC constitutes a promising and technically feasible enhancement of the staged gravitational reduction method. This study shows evidence that VAC may accelerate restoration of the abdominal wall integrity in giant omphalocele, thus minimizing associated comorbidities inherent to a prolonged hospitalization.
Sanguisorba officinalis L. suppresses non-small cell lung cancer via downregulating the PI3K/AKT/mTOR signaling pathway based on network pharmacology and experimental investigation
Authors: Li Hong , Lin Jing , Yang Fei , Deng Junzhu , Lai Jia , Zeng Jing , Zou Wenjun , Jiang Nan , Huang Qianqian , Li Hua , Liu Jian , Li Mao , Zhong Zhirong , Wu Jianming 
Published: November 2022

Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Sanguisorba officinalis L. (SOL), a traditional Chinese herbal medicine called Diyu, has been shown to have potent antitumor effects. However, the role of SOL in suppressing NSCLC remains unknown.Methods: Network pharmacology was employed for acquiring the potential targets and mechanisms of SOL in NSCLC. Based on the predictions of network pharmacology, we used CCK8 and EdU assays to investigate cell proliferation, flow cytometry to investigate apoptosis, wound healing assay to investigate cell migration, and transwell assay to investigate cell invasion in vitro. Western blot was employed for detecting the potential proteins, including signaling pathways and apoptosis. The A549-bearing athymic nude mice were employed to verify the effect on cell proliferation and apoptosis in vivo.Results: SOL significantly inhibited the proliferation, migration and invasion of NSCLC cells in a dose-dependent manner. Flow cytometry showed that the apoptotic ratio and ROS level of NSCLC cells increased significantly with increasing concentrations. AKT and the PI3K-AKT signaling pathway were analyzed as the most relevant target and pathway via network pharmacology predictions. Western blotting revealed that the expression levels of p-PI3K, p-AKT, and p-mTOR in NSCLC cells treated with SOL were significantly downregulated, while cleaved PARP-1 and caspase-3 were upregulated in a dose-dependent manner. The results in the mouse xenograft model were consistent with those in NSCLC cell lines.Conclusion: SOL downregulated the PI3K/AKT/mTOR signaling pathway to suppress NSCLC.
Enneagram typologies and healthy personality to psychosocial stress: A network approach
Authors: Ramos-Vera Cristian , Barrientos Antonio Serpa , Baños-Chaparro Jonatan , Saldarriaga José Vallejos , Saintila Jacksaint 
Published: November 2022

IntroductionEnneagram typologies may impact psychological well-being and stressful situations in college students. However, the literature is still limited in the study of dynamic personality models such as the Enneagram in Spanish-speaking university students, and a better understanding is needed.ObjectiveTo analyze network associations and centrality measures of Enneagram personality typologies in Peruvian university students.MethodsA total of 859 Peruvian university students responded to two instruments assessing: The Pangrazzi’s Enneagram personality types and healthy personality to psychosocial stress. All instruments showed good psychometric values (validity and consistency). A regularized cross-sectional network structure was estimated with Gaussian graphical model and the graphical LASSO.ResultsEnneagram types 4, 5, and 6 presented the highest and positive associations in the network structure. Type 6 emerged as the node with the highest predictability. The healthy personality and type 7 acted as bridges between the communities, with types 6, 7, and 8 being the most central nodes.ConclusionThe findings suggest that Enneagram type 7 with healthy personality to psychosocial stress plays an important role in the development of the causal activation of the network model. The network shows causal associations between psychosocial stress and types 6, 7, 8, and 9.
The stress response of intensive care unit medical doctors facing repeated severe emergencies
Authors: Ciuffini Roberta , Marrelli Alfonso , Leuter Cinzia , Stratta Paolo , Paladini Antonella , Ciccozzi Alessandra , Marsili Ida , Marinangeli Franco , Piroli Alba 
Published: November 2022

ObjectivesThis study assesses the psychopathological distress experienced by doctors working in an Intensive care unit (ICU) during the COVID-19 pandemic. These doctors were the same who faced the consequences of a previous natural disaster, a severe 6.3 magnitude earthquake. A second objective is to evaluate their current mental attitude, professional performances and coping strategies adopted in the pandemic in relation to the conditioning effect of that first emergency, the earthquake.MethodsThirty-seven ICU medical doctors were recruited and assessed using Rapid Stress Assessment (RSA) rating scale, Symptom Checklist-90 Revised (SCL-90-R), Zung Self-Rating Anxiety Scale, Beck Depression Inventory, Beck Hopelessness Scale, Millon Clinical Multiaxial Inventory III. Comparison between exposure to the earthquake and COVID pandemic has been made in terms of professional role and psychological burden.ResultsComparison between 2009 earthquake catastrophe and COVID pandemic conditions evidenced relevant changes in professional role, team, environment, shifts, and work organization.ConclusionThe doctors, who already experienced the 2009 earthquake reported a feeling of greater insecurity facing this latter catastrophe, the COVID pandemic, as well as perception of greater concern for their family and the global situation. However, having participated in the medical management of another emergency (the 2009 earthquake) appears to have contributed to limiting demoralization and psychological distress. The feeling of having greater decision-making possibilities and participation in the organization of work, strengthen coping skills in the face of the emergency.
The viewpoints of residents of Kerman, Iran regarding the challenges and barriers of preparing households against earthquakes: A theory-guided qualitative content analysis
Authors: Rezabeigi Davarani Esmat , Farahmandnia Hojjat , Khanjani Narges , Nekoei-Moghadam Mahmood 
Published: November 2022

IntroductionEarthquakes cause a lot of damage and casualties. For various reasons, most households are not prepared for earthquakes. This study aims to identify the challenges and barriers to households' preparedness against earthquakes from the viewpoint of Kerman residents.MethodsThis qualitative-directed content analysis study was conducted from December 2021 to May 2022 in the city of Kerman in southeast Iran. Data was collected by purposive sampling through in-depth and semi-structured individual face-to-face interviews with 48 households.ResultsAfter multiple rounds of analyzing and summarizing the data based on the social-cognitive theory and taking into consideration similarities and differences, five main categories and 19 subcategories created based on the results of data analysis and including (1) Challenges related to cognitive factors (2) Challenges related to behavioral factors (3) Challenges related to the physical environment (4) Challenges related to the social environment and (5) Challenges related to financial factors.ConclusionAlthough the participants listed many challenges and barriers in different fields, in order to overcome the barriers and challenges of preparing households for an earthquake, the support of the authorities and the cooperation of the residents are necessary.
Potential of native and bioprocessed brewers' spent grains as organic soil amendments
Authors: Cacace Claudio , Cocozza Claudio , Traversa Andreina , Coda Rossana , Rizzello Carlo Giuseppe , Pontonio Erica , De Mastro Francesco , Brunetti Gennaro , Verni Michela 
Published: November 2022

IntroductionThe use of novel soil amendments and the exploitation of plant growth-promoting microorganisms are considered promising tools for developing a more sustainable agriculture in times when ensuring high-yield productions with limited resources is essential.MethodsIn this study, the potential of brewers' spent grain (BSG), the major by-product of the brewing industry, as organic soil amendment, was investigated. Bioprocessed BSG, obtained by an enzymatic treatment coupled with fermentation, together with native BSG, were used as amendments in a pot-trial. An integrated analytical approach aimed at assessing the modification of the physicochemical properties of a typical Mediterranean alkaline agricultural soil, and the plant growth-promoting effect on escarole (Cichorium endivia var. Cuartana), was carried out.ResultsThe use of biomasses led to soil organic content and total nitrogen content up to 72 and 42% higher, compared to the unamended soils. Moreover, the lower pH and the higher organic acids content doubled phosphorus availability. Although the number of leaves per plant in escaroles from pots amended with native and bioprocessed BSG did not show any difference compared to plants cultivated on unamended pots, the average fresh weight per escarole head, was higher in pots amended with bioprocessed BSG.DiscussionHence, the results collected so far encourage BSG application for agricultural purpose, while solving the problem of disposing of such abundant side stream.
Bacteriocins Revitalize Non-Effective Penicillin G to Overcome Methicillin-Resistant Staphylococcus pseudintermedius
Authors: Ovchinnikov Kirill V. , Kranjec Christian , Thorstensen Tage , Carlsen Harald , Diep Dzung B. 
Published: November 2022

The rise of antibiotic-resistant bacteria is among the biggest challenges in human and veterinary medicine. One of the major factors that contributes to resistance is use of frontline clinical antibiotics in veterinary practices. To avoid this problem, searching for antimicrobials aimed at veterinary applications is becoming especially important. Thiopeptide micrococcin P1 and leaderless peptide EntEJ97s are two different bacteriocins that are very active against many gram-positive bacteria; however, sensitive bacteria can rapidly develop resistance towards those bacteriocins. To overcome this problem, we searched for synergy between those bacteriocins and conventional antibiotics against methicillin-resistant Staphylococcus pseudintermedius (MRSP): a common pathogen in animal skin infections. The two bacteriocins acted synergistically with each other and with penicillin G against MRSP clinical isolates in both planktonic and biofilm assays; they also prevented resistance development. The therapeutic potential was further validated in a murine skin infection model that showed that a combination of micrococcin P1, EntEJ97s and penicillin G reduced cell-forming units of MRSP by 2-log10 CFU/g. Taken together, our data show that a combination of bacteriocins with conventional antibiotics can not only prevent resistance development but also pave the way to revitalize some old, less useful antibiotics, such as penicillin, which by itself has no effect on methicillin-resistant pathogens.
Acoustic Roughness Measurement of Railway Tracks: Implementation of a Chord-Based Optical Measurement System on a Train
Authors: Mauz Florian , Wigger Remo , Wahl Tobias , Kuffa Michal , Wegener Konrad 
Published: November 2022

A large part of the noise emissions from rail traffic originates from rolling noise. This is significantly determined by the surface roughness of the wheel and the rail. To quantitatively assess the noise generation from the wheel–rail contact, it is necessary to measure the surface roughness of the rail network. Direct measurements via trolley devices are usually associated with the need for a free track and limitation in velocity. Indirect measurements of rail roughness, such as measuring axle-box accelerations, enable operation during regular passage but only estimate the acoustic roughness. In this study, the potential of an optical and consequently contact-free measurement method using laser triangulation sensors to measure rail roughness from the train is investigated. The approach can combine the advantage of operation during regular passage with the characteristics of a direct measurement, enabling large-scale monitoring of the rail network. A measurement run with a train was carried out on a meter-gauge track at speeds up to 80 km h−1 The results of the optical measurement approach were compared with a tactile reference measurement on the track. The results show good agreement of the new measurement setup for dry rail surface conditions at 50 km h−1, with a mean deviation of 1.48 dB.
Applicability of American College of Radiology Appropriateness Criteria Decision-Making Model for Acute Appendicitis Diagnosis in Children
Authors: Tuncyurek Ozum , Kadam Koray , Uzun Berna , Uzun Ozsahin Dilber 
Published: November 2022

Acute appendicitis is one of the most common causes of abdominal pain in the emergency department and the most common surgical emergency reason for children younger than 15 years of age, which could be enormously dangerous when ruptured. The choice of radiological approach is very important for the diagnosis. In this way, unnecessary surgery is avoided. The aim of this study was to examine the validity of the American College of Radiology appropriateness criteria for radiological imaging in diagnosing acute appendicitis with multivariate decision criteria. In our study, pediatric patients who presented to the emergency department with abdominal pain were grouped according to the Appendicitis Inflammatory Response (AIR) score and the choice of radiological examinations was evaluated with fuzzy-based Preference Ranking Organization Method for Enrichment Evaluation (PROMETHEE) and with the fuzzy-based Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) model for the validation of the results. As a result of this study, non-contrast computed tomography (CT) was recommended as the first choice for patients with low AIR score (where Φnet=0.0733) and with high AIR scores (where Φnet=0.0702) while ultrasound (US) examination was ranked third in patients with high scores. While computed tomography is at the forefront with many criteria used in the study, it is still a remarkable practice that US examination is in the first place in daily routine. Even though there are studies showing the strengths of these tools, this study is unique in that it provides analytical ranking results for this complex decision-making issue and shows the strengths and weaknesses of each alternative for different scenarios, even considering vague information for the acute appendicitis diagnosis in children for different scenarios.
Influence of outdoor advertisements on architecture in the City of Lublin
Authors: Kozak Małgorzata 
Published: November 2022

Polish cities are currently facing an issue of intrusive billboards obstructing the faacades of buildings. While the majority of articles on this subject focus on the negative impact this phenomenon, little attention is drawn to the destructive technical effects the advertisements have on the facades. This article addresses phenomenon of visual pollution examins the influence of based on the example of selected buildings located in Lublin’s City Centre. The article analyses the placement of advertising signs, and categorizes of most technical and social problems that it entails. The relation between the occurrence of outdoor advertising and the increase in anti-social behaviour in commercialised space, raised in the article, could be a very important topic for further research. The results of the conducted study reveal that the installation of advertising billboards irreversibly damages the facades of buildings, which is especially visible when the advertisements are removed. The article complements the study on outdoor advertising, drawing attention to one of its little-discussed, technical aspects. Consequently, it may serve as a starting point for further discussion on the subject.
Comparison of robust machine-learning and deep-learning models for midterm electrical load forecasting
Authors: YAPRAKDAL Fatma , BAL Fatih 
Published: November 2022

Electrical load forecasting (ELF) is gaining importance especially due to the severe impact of climate change on electrical energy usage and dynamically evolving smart grid technologies in the last decades. In this regard, medium-term load forecasting, a crucial need for power system planning (generation optimization and outages plan) and operation control, has become prominent in particular. Machine learning and deep learning-based techniques are currently trending approaches in electrical load estimation due to their capability to model complex non-linearity, feature abstraction and high accuracy, especially in the smart power systems environment.
In this study, several load forecasting models based on machine learning methods which comprise linear regression (LR), decision tree (DT), random forest (RF), gradient boosting, adaBoost, and deep learning techniques such as recurrent neural network (RNN) and long short-term memory (LSTM) are studied for medium-term electrical load demand forecasting at an aggregated level. Performance metric results of these analyzes are presented in detail. State-of-the-art feature selection models are examined on the dataset and their effects on these forecasting methods are evaluated. Numerical results show that forecasting performance can be significantly improved. These results are validated by the results of other studies on the subject and found to be superior.
Sur la corde raide : La Cimade en rétention
Authors: Jacques Geneviève , Lochak Danièle , Rodier Claire 
Published: November 2022

Geneviève Jacques a milité dès les années 1960 au sein de La Cimade dont elle a été la secrétaire générale de 1988 à 1996, puis présidente de 2013 à 2018. Elle retrace l’histoire conflictuelle – en interne comme dans ses relations avec les pouvoirs publics et le secteur associatif – de la défense des personnes étrangères placées en rétention, non sans pointer les contradictions et les limites de l’expression d’une parole critique depuis l’intérieur de ces lieux d’enfermement.
Determining The Authenticity Of Immunacea Bio Tablets With Immunomodulatory Action
Authors: Z.A. Zuparova , G.M. Ismoilova  
Published: November 2022

Modern pharmaceutical practices are characterized by a variety of available dosage forms, but among all dosage forms, tablets are a dominant form.
This work is a dedicated determination of the authenticity of tablets developed based on raw materials of the medicinal plant Echinacea purpurea with immunomodulatory action. The purposeful preparation of drugs with immunomodulatory effects that are capable of nonspecifically stimulating the immune system and increasing the body's resistance to any pathogens is of particular importance.
In this work, the optimal composition of excipients was selected to provide necessary quality indicators for the developed tablets; the quality of the proposed and selected composition of tablets based on dried E. purpurea juice was determined.
The studied tablets called "Immunacea bio" are round, flat-cylindrical, and light brown in colour with patches and smell of vanillin.
In terms of appearance, average weight and deviations from the average weight, disintegration, authenticity and microbiological purity, these tablets comply with regulatory documents. This article developed a method for determining the authenticity of active ingredients and excipients by thin-layer chromatography and determined optimal chromatography conditions, and developers of the active ingredients and excipients.