bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERAN SULTAN DAYANU IKHSANUDDIN DALAM PENYEBARAN AGAMA ISLAM DI BARATA KULISUSU: 1597-1631
Authors: Hidhayati Rini , Hayari Hayari 
Published: April 2022

Artikel ini mengkaji tentang peran Sultan Dayanu Ikhsanuddin dalam penyebaran agama Islam di Barata Kulisusu: 1597-1631 dengan tujuan untuk: (1) Mengetahui proses masuknya Agama Islam di Barata Kulisusu (2) Mengetahui peran Sultan Dayanu Ikhsanuddin dalam menyebarkan agama Islam di Barata Kulisusu (3) Mengetahui dampak penyebaran agama Islam terhadap kehidupan masyarakat di Barata Kulisusu. Metode yang digunakan dalam penelitian ini adalah metode sejarah yang terdiri dari lima tahapan yakni: (1) Pemilihan topik, (2) Heuristik sumber, (3) Verifikasi sumber, (4) Interpretasi, dan (5) Historiografi. Hasil penelitian menunjukkan, (1) Masuknya agama Islam di Barata Kulisusu pada masa Sultan Dayanu Ikhsanuddin dibawa oleh Syekh Gau Malanga/Buraku. Terjadinya proses islamisasi di Barata Kulisusu ketika Syekh Gau Malanga/Buraku mulai mengikuti ajaran dan menikah dengan masyarakat pribumi. Pernihakan Syekh Gau Malanga/Buraku mendapat kepercayaan dari masyarakat terutama dari anggota keluarga dan kerabat dekat istrinya. Posisi inilah yang digunakan Syekh Gau Malanga/Buraku untuk menanamkan ajaran Islam pada masyarakat Kulisusu secara perlahan-lahan sampai akhirnya Islam menjadi agama yang dianut masyarakat Kulisusu. (2) Peran Sultan Dayanu Ikhsanuddin dalam penyebaran Islam di Barata Kulisusu melaui jalur pernikahan dengan Wa Ode Bilahi (3) Penyebaran agama Islam memiliki dampak dalam kehidupan masyarakat Kulisusu yaitu: sosial, politik, serta ekonomi.
The Role of Organizational Commitment and Organization Culture Toward Job Performance
Authors: Tuti Setyorini  , Janri Delastriani Manafe  , Indawati Jauhar Nino  
Published: April 2022

This study seeks to find out the factors that affect lecturers’ performance in Indonesia. Data were collected through a questionnaire participated by 178 active lecturers at the State Polytechnic of Kupang. The present study is important since it may give solutions to enhance the performance of Kupang State Polytechnic lecturers. Data analysis was conducted using the principles of Structural Equation Modeling (SEM). The results of this study demonstrated that there are direct and indirect influences of organizational culture and commitment toward lecturer performance as mediated by Organizational Citizenship Behavior (OCB). This shows the importance of OCB as a situational factor that can improve the performance of teaching staff in an educational institution.

AbstrakPenelitian ini menyelidiki faktor-faktor yang berpengaruh terhadap kinerja dosen di Indonesia. Pengumpulan data dilakukan dengan kuesioner dengan 178 dosen aktif Politeknik Negeri Kupang sebagai responden. Penelitian ini penting karena dapat memberikan solusi bagi peningkatan kinerja dosen di Politeknik Negeri Kupang. Data dianalisa dengan menggunakan Structural Equation Modeling (SEM). Secara langsung maupun tidak langsung terdapat pengaruh dari budaya dan komitmen organisasi terhadap kinerja dosen yang diperantarai oleh Organizational Citizenship Behavior (OCB). Penelitian ini mengetengahkan pentingnya OCB sebagai faktor situasional yang dapat meningkatkan kinerja tenaga pengajar di suatu lembaga pendidikan.
Coherent Control of Molecular Dissociation by Selective Excitation of Nuclear Wave Packets
Authors: López Peña Hugo A. , Shusterman Jacob M. , Ampadu Boateng Derrick , Lao Ka Un , Tibbetts Katharine Moore 
Published: April 2022

We report on pump-probe control schemes to manipulate fragmentation product yields in p-nitrotoluene (PNT) cation. Strong field ionization of PNT prepares the parent cation in the ground electronic state, with coherent vibrational excitation along two normal modes: the C–C–N–O torsional mode at 80 cm−1 and the in-plane ring-stretching mode at 650 cm−1. Both vibrational wave packets are observed as oscillations in parent and fragment ion yields in the mass spectrum upon optical excitation. Excitation with 650 nm selectively fragments the PNT cation into C7H7+, whereas excitation with 400 nm selectively produces C5H5+ and C3H3+. In both cases the ion yield oscillations result from torsional wave packet excitation, but 650 and 400 nm excitation produce oscillations with opposite phases. Ab initio calculations of the ground and excited electronic potential energy surfaces of PNT cation along the C–C–N–O dihedral angle reveal that 400 nm excitation accesses an allowed transition from D0 to D6 at 0° dihedral angle, whereas 650 nm excitation accesses a strongly allowed transition from D0 to D4 at a dihedral angle of 90°. This ability to access different electronic excited states at different locations along the potential energy surface accounts for the selective fragmentation observed with different probe wavelengths. The ring-stretching mode, only observed using 800 nm excitation, is attributed to a D0 to D2 transition at a geometry with 90° dihedral angle and elongated C–N bond length. Collectively, these results demonstrate that strong field ionization induces multimode coherent excitation and that the vibrational wave packets can be excited with specific photon energies at different points on their potential energy surfaces to induce selective fragmentation.
The Role of RNA-Binding Protein HuR in Lung Cancer by RNA Sequencing Analysis
Authors: Ye Xiong , Fu Qiang , Xiao Hui 
Published: April 2022

Background: The overexpression of human antigen R (HuR) has been proven in various types of cancer and is associated with the poor survival lung cancer patients. HuR overexpression stabilizes the mRNA of tumor-promoting genes by binding with 3′-UTR AU-rich elements. However, the role of HuR in the proliferation of lung cancer is unclear.Methods: HuR expression was assessed using immunohistochemistry of tumor tissue samples from ten patients with lung cancer and ten patients with benign lung disease. Gene, protein, mRNA, and lncRNA changes in A549 HuR knockdown (KD) cells were assessed by single-cell RNA sequencing analysis. Furthermore, cell proliferation, migration, and invasion were determined by Cell Counting Kit-8 (CCK-8) assays and Transwell assays with or without Matrigel. The cell cycle was assessed by propidium iodide staining. The protein level, mRNA level and half-life of PLK1 were detected by western blotting and RT-qPCR.Results: In clinical patients, the expression of HuR was significantly higher in lung cancer patients than in patients with benign lung disease. RNA sequencing analysis of A549 HuR knockdown cells revealed that the main function of HuR was related to ribonucleoprotein complex biogenesis. HuR was found to regulate signaling pathways mainly related to the spliceosome, RNA transport and the cell cycle. HuR KD suppressed the proliferation, migration and invasion of A549 cells, indicating its promotive role in these processes.Conclusion: These results demonstrate that HuR plays an important role in the progression of lung cancer.
The Nutritional Intervention of Resveratrol Can Effectively Alleviate the Intestinal Inflammation Associated With Celiac Disease Induced by Wheat Gluten
Authors: Yu Tian , Xie Yiting , Yuan Juanli , Gao Jinyan , Xiao Zhiwen , Wu Yong , Chen Hongbing 
Published: April 2022

Background and AimsWheat gluten is a critical trigger for celiac disease, often causing inflammatory lesions and oxidative stress damage in the intestines of patients. In daily life, it is difficult for celiac disease patients to strictly avoid the dietary intake of gluten, which makes complementary preventive therapy particularly urgent. As such, we investigated the alleviating effects of resveratrol in vivo and in vitro models of celiac disease.MethodsWe established in vivo and in vitro models of gluten protein-induced celiac disease. The intervention effect of resveratrol was defined well based on relevant indicators of inflammation, immunity and oxidative stress, and its possible involvement in signaling pathways and genes were also identified.ResultsResveratrol was effective in reducing intestinal oxidative stress and inflammatory damage induced by wheat gluten in both cell and mouse models for celiac disease. We identified correlations between the genes (Fgf15, Nr0b2, Aire and Ubd) and signaling pathways (PPAR, AMPK and FoxO) in which resveratrol performed critical roles.ConclusionsResveratrol contributed to regulate development of autoimmunity through up-regulation of Aire and Ubd genes and promote nutrient absorption in intestine through down-regulation of Fgf15 and Nr0b2 genes, as well as played a role in regulating complex response system of oxidative stress, inflammatory response and immune response in intestine by activating PPAR, AMPK and FoxO signaling pathways, thus effectively alleviating the intestinal symptoms of celiac disease.
Ultra-High-Field MRI in the Diagnosis and Management of Gliomas: A Systematic Review
Authors: Shaffer Annabelle , Kwok Susanna S. , Naik Anant , Anderson Aaron T. , Lam Fan , Wszalek Tracey , Arnold Paul M. , Hassaneen Wael 
Published: April 2022

Importance:Gliomas, tumors of the central nervous system, are classically diagnosed through invasive surgical biopsy and subsequent histopathological study. Innovations in ultra-high field (UHF) imaging, namely 7-Tesla magnetic resonance imaging (7T MRI) are advancing preoperative tumor grading, visualization of intratumoral structures, and appreciation of small brain structures and lesions.ObjectiveSummarize current innovative uses of UHF imaging techniques in glioma diagnostics and treatment.MethodsA systematic review in accordance with PRISMA guidelines was performed utilizing PubMed. Case reports and series, observational clinical trials, and randomized clinical trials written in English were included. After removing unrelated studies and those with non-human subjects, only those related to 7T MRI were independently reviewed and summarized for data extraction. Some preclinical animal models are briefly described to demonstrate future usages of ultra-high-field imaging.ResultsWe reviewed 46 studies (43 human and 3 animal models) which reported clinical usages of UHF MRI in the diagnosis and management of gliomas. Current literature generally supports greater resolution imaging from 7T compared to 1.5T or 3T MRI, improving visualization of cerebral microbleeds and white and gray matter, and providing more precise localization for radiotherapy targeting. Additionally, studies found that diffusion or susceptibility-weighted imaging techniques applied to 7T MRI, may be used to predict tumor grade, reveal intratumoral structures such as neovasculature and microstructures like axons, and indicate isocitrate dehydrogenase 1 mutation status in preoperative imaging. Similarly, newer imaging techniques such as magnetic resonance spectroscopy and chemical exchange saturation transfer imaging can be performed on 7T MRI to predict tumor grading and treatment efficacy. Geometrical distortion, a known challenge of 7T MRI, was at a tolerable level in all included studies.ConclusionUHF imaging has the potential to preoperatively and non-invasively grade gliomas, provide precise therapy target areas, and visualize lesions not seen on conventional MRI.
Long-Term Results of a Phase 2 Study of Definitive Chemoradiation Therapy Using S-1 for Esophageal Squamous Cell Carcinoma Patients Who Were Elderly or With Serious Comorbidities
Authors: Chen Yun , Zhu Zhengfei , Zhao Weixin , Liu Qi , Zhang Junhua , Deng Jiaying , Ai Dashan , Lu Saiquan , Jiang Liuqing , Tseng Ihsuan , Jia Huixun , Zhao Kuaile 
Published: April 2022

BackgroundThe optimal evidence-based management for the subsets of locally advanced esophageal squamous cell carcinoma (ESCC) patients who rejected or were intolerant to intravenous chemotherapy due to old age or serious comorbidities is currently lacking. This study aimed to assess the safety and local control rate (LCR) of S-1 (tegafur–gimeracil–oteracil potassium) combined with radiotherapy in these subsets of ESCC patients.MethodsLocally advanced ESCC patients who rejected or were intolerant to intravenous chemotherapy due to age &gt;75 years or serious comorbidities were enrolled in a prospective, single-arm, phase 2 trial. The patients were treated with definitive concurrent chemoradiotherapy with S-1, which was administered orally twice daily for 28 days. The radiotherapy dose was 61.2 Gy delivered in 34 fractions. The primary end-point was the 3-year LCR.ResultsOne hundred five ESCC patients were recruited between March 2013 and October 2015. At the median follow-up of 73.1 months (IQR 65.5–81.4 months), 3-year LCR was 61.1%, and 1, 3, and 5-year overall survival was 77.9, 42.3, and 24.8% respectively. For safety analysis, ≥grade 3 acute adverse events included thrombocytopenia (6.7%), leukopenia (2.9%), anemia (1.0%), anorexia (1.0%), fatigue (10.5%), hiccup (1.0%), pneumonitis (4.8%), and esophagitis (3.8%). Two patients (1.9%) died of late esophageal hemorrhage, and one patient (1.0%) died of late radiation-induced pneumonitis.ConclusionS-1 is a promising regimen in concurrent chemoradiotherapy with low toxicity and a favorable LCR in ESCC patients who rejected or were intolerant to intravenous chemotherapy due to old age or serious comorbidities.Clinical Trial RegistrationClinicalTrials.gov, NCT01831531.
Cerebrospinal Fluid Histamine Levels in Healthy Children and Potential Implication for SIDS: Observational Study in a French Tertiary Care Hospital
Authors: Plancoulaine Sabine , Guyon Aurore , Inocente Clara-Odilia , Germe Philippine , Zhang Min , Robert Philippe , Lin Jian-Sheng , Franco Patricia 
Published: April 2022

ObjectiveA defect of the waking systems could constitute a factor of vulnerability for sudden infant death syndrome (SIDS). A decrease in orexin levels, which promotes wakefulness and activates histaminergic neurons (another hypothalamic wake-promoting system) has already been demonstrated between 2 and 6 months. This work aims to study the levels of histamine (HA), tele-methylhistamine (t-MeHA), its direct metabolite, and t-MeHA/HA ratio in the cerebrospinal fluid (CSF) of healthy children, to evaluate the maturation of the histaminergic system and its possible involvement in SIDS.MethodsSeventy Eight French children between 0 and 20 years (48.7% boys) were included, all of whom had a clinical indication for lumbar puncture, but subsequently found to be normal. Measurements of HA and t-MeHA in CSF were performed by reverse phase liquid chromatography coupled to mass spectrometry detection. Statistical analyses were performed using Spearman correlations and Non-parametric pairwise ranking tests.ResultsA negative correlation was found between age and CSF HA (r = −0.44, p &lt; 10−4) and t-MeHA (r = −0.70, p &lt; 10−4) levels. In pairwise comparisons, no difference in CSF HA and t-MeHA levels was observed between youngest age groups (i.e., 0–2 mo vs. 3–6 mo), but CSF HA and t-MeHA levels were significantly lower in older children (i.e., &gt;6 mo vs. 0–6 mo). The CSF HA decrease with age was only observed in boys, who also presented global lower CSF HA levels than girls.ConclusionCSF HA and t-MeHA levels decrease with age in boys, and global levels are lower in boys than in girls. These results reveal changes in histaminergic transmission and metabolism during maturation. Whether lower CSF histamine values in boys compared to girls could contribute to their higher risk of SIDS warrants further research.
Application of Argon Plasma Coagulation for Gastrointestinal Angiodysplasia in Children— Experience From a Tertiary Center
Authors: Yeh Pai-Jui , Le Puo-Hsien , Chen Chien-Chang , Chao Hsun-Chin , Lai Ming-Wei 
Published: April 2022

BackgroundArgon plasma coagulation (APC) has been applied in adults to treat various diseases, including vascular lesions in the gastrointestinal (GI) tract. However, angiodysplasia (AD) is an uncommon cause of pediatric GI bleeding, while the experience of treating AD with APC was rarely reported.MethodsFive children with AD in the GI tract successfully treated with APC were reviewed.ResultsThree of the five patients were girls, and the age at diagnosis ranged from 1.5 months to 10.5 years of age. One patient with gastric AD manifested with tarry stool, and the rest had colonic AD, which caused various degrees of bloody stool. Three patients had evident anemia. All patients received an endoscopic diagnosis, and two had compatible findings in radiographic exams. Each patient underwent one APC treatment session, and none encountered procedure-related complications or re-bleeding.ConclusionAD can be an etiology of GI bleeding even in neonates. APC is an effective and safe therapy for symptomatic AD in children.
Efficacy of Systemic Biologic Drugs in Pediatric Psoriasis: Evidence From Five Selected Randomized Clinical Trials
Authors: Di Lernia Vito , Macca Laura , Peterle Lucia , Ingrasciotta Ylenia , Trifirò Gianluca , Guarneri Claudio 
Published: April 2022

Background: Psoriasis is a chronic, immune-mediated skin disease that may occur at any age. Prevalence in children ranges between 0.5 and 1.0% across Europe. Approximately 10–20% of paediatric psoriasis patients are moderate-to-severe in severity and may require the use of systemic therapy.Objective: Recently, newer targeted, systemic therapies have been licensed for treatment of moderate-to-severe paediatric psoriasis. The objective of this study was to evaluate the short-term efficacy of available antipsoriatic systemic drugs in children with a narrative synthesis of key efficacy from randomized clinical trials.Methods: A systematic review of literature was performed on Medline and embase databases and the Cochrane Central Register of Controlled Trials. Randomized clinical trials investigating the efficacy of treatments licensed by the US Food and Drug Administration and/or the European Medicines Agency for paediatric and adolescent psoriatic population were retrieved and analyzed. Data from this literature review was assessed in line with GRADE (grading of recommendations, assessment, development and evaluations). The short-term (12-16 weeks) clinical efficacy from baseline was evaluated according to the Psoriasis Area and Severity Index (PASI) 75 and 90 compared to baseline. Illustrative comparative risks, relative risk (RR) and the number needed to treat (NNT) for response on PASI 75 and PASI 90 were extracted.Results: A total of five relevant studies were identified on two TNF-alpha blockers (etanercept and adalimumab), the IL12/23 inhibitor ustekinumab and two IL-17 inhibitors (ixekizumab, secukinumab). Comparators were placebo (3 studies), placebo and etanercept (1 study) methotrexate (1 study). All examined drugs resulted efficacious. The probability to achieve PASI 75 and PASI 90 was higher for the IL-12/23 and IL-17 inhibitors. Overall, the anti-IL17s and the anti-IL12/23 antibodies showed a more favourable NNT for PASI 75, whereas IL-17 inhibitors for PASI 90.Conclusion: The approved biological therapies may be beneficial for the treatment of moderate to severe plaque psoriasis in children and adolescents. Since psoriasis is a chronic and often challenging condition with no definitive solution, systematic evaluations of long-term efficacy, drug survival and adverse effects may help careful, individualized, patient-centered clinical decision making.
Ventricular-Vascular Uncoupling in Heart Failure: Effects of Arterial Baroreflex-Induced Sympathoexcitation at Rest and During Exercise
Authors: Mannozzi Joseph , Al-Hassan Mohamed-Hussein , Kaur Jasdeep , Lessanework Beruk , Alvarez Alberto , Massoud Louis , Bhatti Tauheed , O’Leary Donal S. 
Published: April 2022

Autonomic alterations in blood pressure are primarily a result of arterial baroreflex modulation of systemic vascular resistance and cardiac output on a beat-by-beat basis. The combined central and peripheral control by the baroreflex likely acts to maintain efficient energy transfer from the heart to the systemic vasculature; termed ventricular-vascular coupling. This level of control is maintained whether at rest or during exercise in healthy subjects. During heart failure, the ventricular-vascular relationship is uncoupled and baroreflex dysfunction is apparent. We investigated if baroreflex dysfunction in heart failure exacerbated ventricular-vascular uncoupling at rest, and during exercise in response to baroreceptor unloading by performing bilateral carotid occlusions in chronically instrumented conscious canines. We observed in healthy subjects that baroreceptor unloading caused significant increases in effective arterial elastance (Ea) at rest (1.2 ± 0.3 mmHg/ml) and during exercise (1.3 ± 0.2 mmHg/ml) that coincided with significant increases in stroke work (SW) (1.5 ± 0.2 mmHg/ml) and (1.6 ± 0.2 mmHg/ml) suggesting maintained ventricular-vascular coupling. Heart Failure significantly increased the effect of baroreceptor unloading on Ea at rest (3.1 ± 0.7 mmHg/ml) and during exercise (2.3 ± 0.5 mmHg/ml) whereas no significant increases in stroke work occurred, thus signifying further ventricular-vascular uncoupling. We believe that the enhanced ventricular-vascular uncoupling observed during baroreceptor unloading only worsens the already challenged orthostatic and exercise tolerance and thereby contributes to poor exercise performance and quality of life for heart failure patients.
Cognitive Dysfunction of Chikungunya Virus Infection in Older Adults
Authors: Peixoto Vanessa Giffoni M. N. P. , Azevedo Julianna P. , Luz Kleber G. , Almondes Katie M. 
Published: April 2022

BackgroundChikungunya fever is a disabling articular disease caused by chikungunya virus (CHIKV). In the past decade it has affected millions of people across America, Africa, Asia, and Europe, turning this infection into a public health concern. The acute phase of chikungunya infection is usually self-limiting, characterized by severe arthralgia, fever, chills, myalgia, headache, and rash. CHIKV neurovirulence is evident and seems to be higher among elders. Considering their susceptibility to cognitive decline and dementia, the aim of our study was to investigate whether CHIKV infection might cause long-term cognitive impairment in aged people.MethodsA cross-sectional study was conducted with volunteers aged from 60 to 90 who had been affected by chikungunya and also with healthy controls. A structured questionnaire was used to record demographic and clinical data, functional status, and depression. Global cognitive function was assessed through MoCA. A comprehensive neuropsychological battery was performed to assess specific cognitive functions.ResultsSubjective memory complaints were present in 70% of subjects with previous chikungunya. This group had a poorer performance in MoCA (p = 0.000) and specific cognitive tests: Semantic (p = 0.05) and Phonemic Verbal Fluency (p = 0.003), 5-Digit (choice, reading, counting and alternance, p = 0.003, p = 0.014, p = 0.021, and p = 0.021, respectively), Stroop test (time, errors and interference, p = 0.000, p = 0.027 and p = 0.015, respectively), and RAVLT (word total session p = 0.05). These tests reflect performance on general executive functions, cognitive flexibility, inhibitory control, processing speed, semantic memory and episodic memory.ConclusionOur data suggest that CHIKV infection may cause long-term cognitive decline in aged people and might be a risk factor for future dementia in this population.