bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiome-Based Therapies in Parkinson’s Disease: Can Tuning the
Microbiota Become a Viable Therapeutic Strategy?
Authors: Onaolapo Adejoke Y. , Ojo Folusho O. , Olofinnade Anthony T. , Falade Joshua , Lawal Ismail A. , Onaolapo Olakunle J. 
Published: September 2022

Abstract:
Progressive neurodegenerative disorders such as Parkinson’s disease (PD) have continued
to baffle medical science, despite strides in the understanding of their pathology. The inability of currently
available therapies to halt disease progression is a testament to an incomplete understanding of
pathways crucial to disease initiation, progression and management. Science has continued to link the
activities and equilibrium of the gut microbiome to the health and proper functioning of brain neurons.
They also continue to stir interest in the potential applications of technologies that may shift the balance
of the gut microbiome towards achieving a favourable outcome in PD management. There have
been suggestions that an improved understanding of the roles of the gut microbiota is likely to lead to
the emergence of an era where their manipulation becomes a recognized strategy for PD management.
This review examines the current state of our journey in the quest to understand how gut microbiota
can influence several aspects of PD. We highlight the relationship between the gut microbiome/
microbiota and PD pathogenesis, as well as preclinical and clinical evidence evaluating the effect of
postbiotics, probiotics and prebiotics in PD management. This is with a view to ascertaining if we are
at the threshold of discovering the application of a usable tool in our quest for disease modifying therapies
in PD.
Protein Uncoupling as an Innovative Practice in Diabetes Mellitus
Treatment: A Metabolic Disorder
Authors: Chaudhary Rishabh , Gupta Sumeet , Chauhan Samrat 
Published: September 2022

Background:
Uncoupling proteins (UCPs) are unpaired electron carriers that uncouple
oxygen intake by the electron transport chain from ATP production in the inner membrane of the
mitochondria. The physiological activities of UCPs have been hotly contested, and the
involvement of UCPs in the pathogenesis and progression of diabetes mellitus is among the
greatest concerns. UCPs are hypothesised to be triggered by superoxide and then reduce
mitochondrial free radical production, potentially protecting diabetes mellitus patients who are
experiencing oxidative stress.

Objectives:
The objectives of the study are to find out the newest ways to treat diabetes mellitus
through protein uncoupling.

Methods:
Research and review papers are collected from different databases like google scholar,
PubMed, Mendeley, Scopus, Science Open, Directory of open access journals, and Education
Resources Information Center, using different keywords such as “uncoupling proteins in diabetes
mellitus treatment”, “UCP 1”, “UCP 2”, and ‘UCP 3”.

Results:
UCP1, UCP2, and UCP 3 are potential targets as uncoupling proteins for the treatment
of diabetes mellitus for new drugs. New drugs treat the disease by reducing oxidative stress
through thermogenesis and energy expenditure.

Conclusion:
UCP1, UCP2, and UCP3 have a role in fatty acid metabolism, negative control of
insulin production, and insulin sensitivity by beta-cells. Polymorphisms in the UCP 1, 2, and 3
genes significantly reduce the risk of developing diabetes mellitus. Protein uncoupling indirectly
targets the GPCR and islet of Langerhans. This review summarises the advances in understanding
the role of UCP1, UCP2, and UCP3 in diabetes mellitus.
Staff Nurses’ Perceptions of Barriers and Facilitators of Effective Nursing Leadership in a Major Saudi Hospital
Authors: Alenezi Ibrahim 
Published: September 2022

Background:
Leadership skills on the part of nursing managers are expected to improve care for patients under the care of registered nurses. To do so also requires all Saudi hospital nursing leaders to attract and retain qualified nursing staff during a time of global shortages.

Aim:
The purpose of this study is to explore and identify the staff nurse perceptions of the barriers to and facilitators of effective nurse leadership for a major Saudi hospital and make recommendations for change.

Methods:
An interpretative methodology guided by John Kotter’s change theory. Qualitative data were collected from 14 participants using semi-structured interviews in 2016 and analysed using content analysis.

Results:
Two main categories have been identified through the data analysis process. The first category was barriers to effective leadership, comprising an inadequate leadership education and skills development; a limited authority and clinical empowerment; an unawareness of the need for change; and poor communication. The second category was facilitators of effective leadership, encapsulated engaging and listening to staff and seeking their ideas; recognizing staff performance, and motivational strategies.

Conclusion:
Even though the staff nurses who participated in this study were dissatisfied with the quality of leadership shown by their nurse managers, nevertheless they proffered an abundance of data during the study which accentuated the variety of organizational obstacles encountered by their nursing managers. They also voiced opinions on the workplace factors which might serve to assist nurse managers to improve the efficacy of their guidance. These were included in the study recommendations which were forwarded to all nursing managers employed at the hospital.
Combined Bazedoxifene and Genistein Ameliorate Ovariectomy-Induced
Hippocampal Neuro-Alterations via Activating CREB/BDNF/TrkB
Signaling Pathway
Authors: Samak Mai A. , Abdelrahman Abeer A. , Samy Walaa , Abdelrahman Shaimaa A. 
Published: September 2022

Objectives:
The scientific research community devotes stupendous efforts to control
the arguable counterbalance between the undesirable effects of hormone replacement therapy
(HRT) and post-menopausal syndrome. The recent emergence of 3rd generation selective estrogen
receptor modulators and phytoestrogens has provided a promising alternative to HRT.
Hence, we assessed the potential effects of combined Bazedoxifene and Genistein on
hippocampal neuro-alterations induced by experimental ovariectomy.

Methods:
For this purpose, we utilized forty-eight healthy sexually mature female Wistar rats assorted
to control, ovariectomy (OVX), Genistein-treated ovariectomized (OVX+GEN) and
Bazedoxifene and Genistein-treated ovariectomized (OVX+BZA+GEN) groups. Hippocampi
samples from various groups were examined by H&E, silver stains and immunohistochemical
examination for calbindin-D28k, GFAP, and BAX proteins. We also assessed hippocampal
mRNA expression of ERK, CREB, BDNF and TrkB.

Results:
Our histopathological results confirmed that combined BZA+GEN induced restoration
of hippocampal neuronal architecture, significant reduction of GFAP and BAX mean area % and
significant upregulation of calbindin-D28k immunoexpression. Furthermore, we observed significant
upregulation of ERK, CREB, BDNF and TrkB mRNA expression in the BZA+GEN group
compared to the OVX group.

Conclusion:
Taken together, our findings have provided a comprehensive assessment of histological,
immunohistochemical and cyto-molecular basis of combined Genistein and Bazedoxifene
ameliorative impacts on hippocampal neuro-alterations of OVX rats via upregulation of
Calbindin, CERB, BDNF, Trk-B and ERK neuronal expression.
Peculiarities of Bioaccumulation and Toxic Effects Produced by Nanoparticles of Molybdenum (VI) Oxide under Multiple Oral Exposure of Rats: Examination and Comparative Assessment
Authors: Zaitseva Nina Vladimirovna , Zemlyanova Marina Aleksandrovna , Stepankov Mark Sergeevich , Ignatova Anna Mikhailovna , Pustovalova Olga Vasilievna , Nikolaeva Alyona Evgenievna 
Published: September 2022

Introduction:Molybdenum (VI) oxide nanoparticles (MoO3 NPs) are widely used in various economic activities. This creates elevated risks of exposure to this nanomaterial for workers and the population in general, and consequently, there can be an increased number of developing pathological changes caused by exposure to MoO3 NPs.Objective:The study aims to examine and comparatively assess peculiarities of bioaccumulation and toxic effects produced by MoO NPs under multiple oral introductions.Methods:We evaluated the sizes of analyzed particles by scanning electronic microscopy; the specific surface area was calculated by the method of Brunauer, Emmett and Taylor; the total pore volume by Barrett, Joyner and Halenda. Rats were exposed as per the scheme introduced by Lim with colleagues. We examined biochemical and hematological blood indicators, molybdenum concentrations, and pathomorphological changes in tissues of various organs 24 hours after the last exposure. The study involved a comparison with effects produced by MoO3 microparticles.Results:We evaluated the sizes of analyzed particles by scanning electronic microscopy; the specific surface area was calculated by the method of Brunauer, Emmett and Taylor; the total pore volume by Barrett, Joyner and Halenda. Rats were exposed as per the scheme introduced by Lim with colleagues. We examined biochemical and hematological blood indicators, molybdenum concentrations, and pathomorphological changes in tissues of various organs 24 hours after the last exposure. The study involved a comparison with effects produced by MoO3 microparticles.Conclusion:MoO3 NPs are more able to bioaccumulate and produce toxic effects compared with their microdispersed analogue under multiple oral introductions into the body.
Amalgamation of Nanoparticles within Drug Carriers: A Synergistic
Approach or a Futile Attempt?
Authors: Mehta Nikhil , Pai Rohan 
Published: September 2022

Abstract:
In recent years, nanotechnology has gained much attention from scientists for the
obtainment of significant advances in therapeutic potential. Nano-delivery systems have emerged
as an effective way to improve the therapeutic properties of drugs, including solubility, stability,
prolongation of half-life, as well as promoting the accumulation of drug at the target site. The
nanoparticles have also been incorporated into various conventional drug delivery systems. This
review study aims to introduce the amalgamation of nanoparticles into drug carriers. To overcome
the limitations of single nanoparticles, such as toxicity, high instability, rapid drug release as well
as limited drug loading capacity, a multi-component system is developed. Liposomes,
microparticles, nanofibers, dendrimers, etc., are promising drug carriers, having some limitations
that can be minimized, and the compilation of nanoparticles synergizes the properties. The
amalgamated nanocarriers are used for the diagnostic purpose as well as treatment of various
chronic diseases. It also increases the solubility of hydrophobic drugs. However, each system has
its advantages and disadvantages based on its physicochemical properties, efficacy, and other
parameters. This review details the past and present state of development for the fusion of
nanoparticles within drug carriers and future research works are needed for the same.
National Trends in the Us e of Herbal Medicines for the Treatm ent of
Hypertens ion Among Adults in Mongolia from Four Cross-Sectional Surveys
in 2005, 2009, 2013, and 2019
Authors: Peltzer Karl , Pengpid Supa 
Published: September 2022

Background:
The use of herbal and combined herbal and conventional treatments in people with chronic diseases, such as hypertension, is important. The aim of the present study was to assess national trends in using traditional medicines for the treatment of hypertension among adults in Mongolia from four cross-sectional surveys in 2005, 2009, 2013 and 2019.

Methods:
Cross-sectional data were analysed from 5,657 persons (15-64 years) of known hypertensives that participated in the 2005, 2009, 2013 or 2019 Mongolia STEPS surveys. Those who knew their hypertension status were asked about the past two weeks of intake of any drug (medication) for increased blood pressure prescribed by a doctor or other health worker, and the current intake of any herbal or traditional remedy for elevated blood pressure. Logistic regression was employed to assess the associations between sociodemographic and comorbid factors and herbal use and concurrent herbal and conventional treatment.

Results:
The prevalence of known hypertensives slightly increased from 19.0% in 2005 to 23.7% in 2019. The prevalence of current conventional treatment for hypertension among known hypertensives significantly decreased from 74.5% in 2005 to 40.1% in 2019. The proportion of current herbal treatment for hypertension among known hypertensives was overall 6.3% and decreased significantly from 11.7% in 2005 to 9.0% in 2019. The prevalence of current herbal and conventional treatment for hypertension among known hypertensives was overall 4.4%, and significantly decreased from 9.9% in 2005 to 6.0% in 2019. In the 2005 survey, the prevalence of herbal use was significantly higher among those with 12 or more years of education (p<0.01) and urban residence (p<0.001), while in the study years 2009, 2013 and 2019, no significant differences were found in terms of educational level and residence status and prevalence of herbal use.
In adjusted logistic regression analysis, inadequate fruit and vegetable consumption decreased the odds and older age increased the odds of herbal use and/or concurrent herbal and conventional treatment for hypertension among hypertensives.

Conclusion:
The prevalence of herbal and/or conventional treatment of hypertension among hypertensives has decreased among Mongolian adults over a 15-year period. Considering significant levels of herbal treatment in combination with conventional treatment for hypertension, negative drug-herb effects can be expected, and appropriate actions of health systems may be needed.
Recent Advancements in Hyperthermia-Driven Controlled Drug Delivery
from Nanotherapeutics
Authors: Baig Mirza Shahed , Haque Mohammad Akiful , Konatham Teja Kumar Reddy , Mohammad Badrud Duza , Yahya Barrawaz Aateka , Saffiruddin Shaikh Sana , Siddiqui Falak A. , Khan Sharuk L. 
Published: September 2022

Abstract:
Previous reviews of the works on magnetic nanoparticles for hyperthermia-induced treatment
concentrated mostly on magnetic fluid hyperthermia (MFH) employing monometallic/metal oxide
nanocomposites. In the literature, the word "hyperthermia" was also limited to the use of heat for
medicinal purposes. A number of articles have recently been published demonstrating that magnetic
nanoparticle-based hyperthermia may produce restricted high temperatures, resulting in the release of
medicines that are either connected to the magnetic nanoparticles or encased in polymer matrices. In
this debate, we propose broadening the concept of "hyperthermia" to encompass temperature-based
treatment as well as magnetically controlled medication delivery. The review also addresses core-shell
magnetic nanomaterials, particularly nanoshells made by stacked assembly, for the use of hyperthermia-
based treatment and precise administration of drugs. The primary objective of this review article
is to demonstrate how the combination of hyperthermia-induced therapy and on-demand' drug release
models may lead to effective applications in personalized medicine.
Colonization by Various Morphological Forms of Helicobacter
pylori in the Gingival Sulcus and Antrum of the Stomach
Authors: Gladyshev Nikita , Taame Maria , Ibiliev Askhab , Grukhin Yuriy , Kravtsov Viacheslav 
Published: September 2022

Background:
Helicobacter pylori eradication therapy can be considered effective
if the result of its implementation is removed including all roots and rootlets
from which surviving H. pylori can repopulate in the gastric mucosa. One of the reasons
for the ineffectiveness of eradication therapy can be the continuous presence of viable
coccoid forms of H. pylori in the oral cavity. Therefore, anti-Helicobacter eradication
therapy should be supplemented by the sanitation of the oral cavity.

Objectives:
The objective of this study is to determine the frequency of occurrence of H.
pylori in the gastric mucosa and in the oral cavity in patients with chronic periodontitis
or with chronic gastritis using immunocytochemical method and to evaluate the pathophysiological
relationship between periodontitis and HP-associated acid-dependent
stomach diseases mediated by H. pylori.

Methods:
A group of patients with chronic gastritis (70 participants, 46 women, 24
men, age: 24 - 55 years) and another group with chronic periodontitis before the start of
surgical treatment (61 participants, 30 women, 31 men, age: 20 - 60 years) were examined
for НР bacterial cells using immunocytochemical methods of staining gastric biopsy
and exfoliate samples from the gingival sulcus surface. The participants did not take
any antimicrobial medication before and during the examination. Routine staining was
also performed to view microbiota in smears for both groups.
The participants signed a voluntary consent agreement to undergo routine medical examinations
and join the study at the Nikiforov Russian Centre of Emergency and Radiation
Medicine, EMERCOM of Russia, where the ethical committee was made.

Results:
Immunocytochemical method could identify all stages of bacillary-coccoid
transformation of H. pylori which accounted for 63.4-67.5% of cases. HP-antigenpositive
bacteria were found in the oral cavity in both groups of examined patients. It
was apparent that spiral forms of H. pylori were dominant over coccoid forms in the
gastric mucosa in the antrum of the stomach, whereas coccoid forms of H. pylori were
frequently found more in the oral cavity. Helicobacteriosis in the oral cavity was identified
in chronic periodontitis.

Conclusion:
We found certain pathogenetic connections between inflammatory lesions
of the oral cavity and diseases of the internal organs of the gastrointestinal tract. Accordingly,
we suggest the necessity to use proper medication for oral cavity sanitation along with
anti-Helicobacter eradication therapy to influence the HP reservoir in the oral cavity and
gingival sulcus. Additionally, bacterial cells of HP reside in the oral cavity in coccoid forms;
therefore, the coccoid form of HP should become the second principal target in treating HP.
Analisa Quantity Take Off Dan Rencana Anggaran Biaya Dengan Metode Building Information Modeling (BIM) Menggunakan Software Autodeks Revit 2019 (Studi Kasus: Gedung LP3 Universitas Negeri Semarang)
Authors: Novita Rizki Dwi , Pangestuti Endah Kanti 
Published: September 2022

Perkembangan dunia konstruksi berkembang semakin pesat. Semua pihak yang terlibat dalam proyek konstruksi, baik itu kontraktor, konsultan, owner maupun pihak-pihak yang berkenpentingan dintutut supaya mampu mencari sebuah solusi untuk menyelesaikan proyek-proyek konstruksi dalam kurun waktu yang cepat. Di dalam sebuah proyek konstruksi perhitungan volume merupakan hal yang sangat penting. Apabila terjadi kesalahan dalam perhitungan volume pekerjaan maka dapat mengakibatkan kerugian yang sangat besar. Sehingga metode perhitungan volume secara konvesional yaitu dengan metode perhitungan berdasarkan pada gambar Autocad dengan dibantu Microsoft Excel yang berpedoman pada SMM (Standard Method of Measurement) yang saat ini masih dilakukan oleh beberapa pihak yang memungkinkan terjadi human error dan membutuhkan waktu yang cukup lama perlu diganti dengan metode Building Information Modeling (BIM) dengan menggunakan software Autodeks Revit yang dapat menghitung volume dan Rencana Anggaran Biaya (RAB) secara efektif dan efisien. Pada penelitian ini menggunakan cara atau metode perencanaan menggunakan Revit untuk mendesain bagian struktur (tanpa tangga) bangunan berupa pembetonan pondasi bore pile, pile cap, tie beam, kolom dan balok serta plat. Kemudian akan diperoleh volume dan Rencana Anggaran Biaya (RAB). Berdasarkan hasil penelitian yang telah dilakukan diperoleh hasil perhitungan dari Revit berupa volume total pembetonan sebesar 1647,99 m3 dan Rencana Anggaran Biaya (RAB) sebesar Rp 1.604.376.387,67
Pengendalian Ruang pada Kawasan Situ Cipondoh di Kota Tangerang, Provinsi Banten: Kajian Kebijakan
Authors: Tranggono Moch. 
Published: September 2022

Situ Cipondoh merupakan salah satu reservoir yang memiliki peranan penting di Kota TangerangProvinsi Banten. Perubahan kondisi sempadan dari waktu ke waktu sebagai akibatnya terjadinya peningkatan kebutuhan masyarakat terhadap lahan di kawasan perkotaan. Kajian ini bertujuan untuk: 1) melakukan telaah rangkaian model pengendalian instrument tata ruang terhadap kawasan Sempadan Situ Cipondoh; 2) Menyusun rangkaian rencana aksi dan sinkronisasi terhadap penegakan dan penertiban penggunaan lahan yang tidak sesuai dengan penetapan RTRW Provinsi Banten. Metode kajian yang digunakan dalam studi ini dilakukan melalui telaah regulasi sebagai dasar awal identifikasi kondisi RTRW Provinsi Banten, kemudian dilakukan survei sebagai tindak lanjut dengan terlebih dahulu melakukan penarikan garis sempadan sebagai dasar keruangan terhadap kondisi sempadan Situ Cipondoh. Kajian ini digunakan sebagai dasar pengambil keputusan dan rekomendasi untuk pengendalian tata ruang kawasan Situ Cipondoh.
Analisis Karakteristik dan Kebutuhan Parkir Kendaraan Pada Rumah Sakit Karima Utama Surakarta
Authors: Mulyono Gotot Slamet , Saputra Dwi Eko , Setiyaningsih Ika 
Published: September 2022

Rumah Sakit Karima Utama Surakarta adalah Rumah Sakit Khusus Bedah yang termasuk dalam Rumah Sakit dengan Tipe C untuk melayani kebutuhan medis masyarakat setempat. Fasilitas tersebut harus memiliki fasilitas parkir yang cukup luas. Karena rumah sakit umumnya memiliki tempat parkir yang terbatas, sebagian bahu jalan diubah menjadi tempat parkir. Tujuan dari penelitian ini adalah untuk mengetahui karakteristik parkir dan perlu diperhatikan dalam pengelolaan ruang parkir. Data yang digunakan adalah data sekunder berupa waktu masuk/keluar masing-masing kendaraan, diperoleh dalam format tabel dari server parkir rumah sakit mulai pukul 07.00 sd 19 18 dan 20 Januari 2020, 12 jam sehari. 00 WIB. Analisis didasarkan pada pedoman Direktur Perhubungan Darat 1998, termasuk akumulasi tempat parkir, pengindeksan tempat parkir, jam parkir, volume tempat parkir, roaming tempat parkir, dan permintaan tempat parkir. Menurut analisis hari Senin, kumulatif harian tertinggi adalah 132/15 menit dengan mobil dan 253/15 menit dengan sepeda motor. Rata-rata jumlah mobil per hari adalah 239/12 jam dengan mobil dan 540,5/12 jam dengan sepeda motor.. Indeks parkir tertinggi mobil penumpang sebesar 110.00% dan sepeda motor 110,48% dengan rata rata durasi parkir harian untuk mobil penumpang adalah 197,86 menit dan untuk sepeda motor 156,84 menit. Tingkat turnover parkir mobil penumpang dan sepeda motor tertinggi terjadi sebesar 2,45 dan sepeda motor sebesar 3,14.