bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of adult primary immune thrombocytopenia in England—An update
Authors: Doobaree Indraraj Umesh , Conway Katherine , Miah Haroon , Miah Atiqa , Makris Michael , Hill Quentin , Cooper Nicola , Bradbury Charlotte , Newland Adrian , Provan Drew , McDonald Vickie ,   UK adult ITP registry
Published: June 2022

AbstractBackgroundAdult primary immune thrombocytopenia (ITP) is a rare bleeding disorder of unknown cause. Recent estimates of its incidence and trend over time were acquired for England.MethodThe primary ITP population (using ICD 10 code D693 and excluding secondary ITP cases; positive predictive value: 82.6%) was sourced from NHS Digital inpatient and outpatient. Incidence rate (IR) for England and by age groups, sex, and regions were calculated and trends were assessed using average annual percent change (AAPC).ResultsA total of 25 805 patients (mean age 59 years; females 57.8%) diagnosed between 2003 and 2014 was identified. IRs increased from 4.2/100 000 to 6.4/100 000 over this period (AAPC:4.3%). For all sex‐specific age groups, the IRs significantly increased over time, except 18–29 years males. The greatest increase was among females aged 30–39 (AAPC:8.7%). In contrast, among ≥70 years, ITP was more common in males (highest IR among ≥80 years males: 23.9/100 000). England's average annual IR was 6.1/100 000 for 2010–14. An estimated 2.5/100 000 (based on UKITP Registry data) was estimated to require 1st line treatment whereas 2.4/100 000 would have 1st and 2nd line treatments within 6 months from diagnosis. IRs for London and East Midlands were the highest (6.5/100 000).ConclusionsThis study found a rising incidence of primary ITP, with sharp increases among young women and elderly men. These findings put in context the impact of ITP on patients' lives and the healthcare services in England, especially with 17%–50% who may develop chronic ITP and require long‐term care.
Bidirectional relationships between parenting stress and child behavior problems in multi‐stressed, single‐mother families: A cross‐lagged panel model
Authors: Jiang Qingyu , Wang Dan , Yang Zhenqiao , Choi Jeong‐Kyun 
Published: June 2022

AbstractInvestigations on the bidirectional relationships between parenting stress and child behavior problems are important to inform intervention strategies; however, prior research has provided inconsistent findings. Using a national sample of multi‐stressed single‐mother families from the Fragile Families and Child Wellbeing study, the present study examined the bidirectional relationships between maternal parenting stress and children's behavioral problems spanning from early childhood through adolescence at the child's ages 3, 5, 9, and 15. Reciprocal transactions were found between parenting stress and behavior problems in early childhood between the ages 3 and 5. From age 5 to age 15, our findings also suggest that children's behavior problems at an earlier time point predict mothers' parenting stress at a later time point. Unexpectedly, the lagged effects of parenting stress on child behavior problems in school ages were not significant in our sampled data. Early childhood interventions should address mitigating both parenting stress and their toddlers' behavior problems. During middle childhood and adolescence, interventions to directly address children's behavior problems are critical both to the well‐being of mothers and to assist in the reduction in levels of behavior problems.
Impact of bodyweight‐based starting doses on the safety and efficacy of lenvatinib in primarily Japanese patients with hepatocellular carcinoma
Authors: Okusaka Takuji , Kudo Masatoshi , Ikeda Kenji , Ikeda Masafumi , Okita Kiwamu , Sugawara Michiko , Tamai Toshiyuki , Ren Min , Saito Kenichi , Kumada Hiromitsu 
Published: June 2022

AbstractAimThe phase III REFLECT study utilized bodyweight‐based lenvatinib dosing in patients with unresectable hepatocellular carcinoma, based on results of the phase II Study 202. This post hoc analysis compared efficacy and safety in patients with lower and higher bodyweights.MethodsThis comparison included patients from Study 202 (Japanese, n = 43; Korean, n = 3) and Japanese patients from REFLECT (n = 81) who received lenvatinib. In Study 202, all patients received a starting dose of lenvatinib 12 mg/day; in REFLECT, patients received starting doses based on bodyweight (patients <60 kg, 8 mg/day; ≥60 kg, 12 mg/day). Safety and efficacy were assessed in both studies according to bodyweight.ResultsIn Study 202, treatment‐related, treatment‐emergent adverse events (TEAEs) led to dose reductions in 80.8% and 55.0% of patients in the lower and higher bodyweight groups, respectively. In REFLECT, treatment‐related TEAEs led to dose reductions in 52.5% and 70.7% of patients in the 8 and 12 mg groups, respectively. In Study 202, median overall survival (OS) was 16.2 months (95% confidence interval [CI], 9.8–25.1) and 21.3 months (95% CI, 10.1–not estimable) in the lower and higher bodyweight groups, respectively. In REFLECT, median OS was 15.8 months (95% CI, 10.4–27.6) and 18.2 months (95% CI, 11.3–26.9) in the 8 and 12 mg groups, respectively.ConclusionsComparison between patients in Study 202 and REFLECT demonstrates efficacy was maintained with improved safety in patients with lower bodyweights who received lenvatinib 8 mg/day in REFLECT versus patients who received lenvatinib 12 mg/day in Study 202.
Present status and future directions: Surgical endodontics
Authors: Setzer Frank C. , Kratchman Samuel I. 
Published: June 2022

AbstractEndodontic surgery encompasses several procedures for the treatment of teeth with a history of failed root canal treatment, such as root‐end surgery, crown and root resections, surgical perforation repair and intentional replantation. Endodontic microsurgery is the evolution of the traditional apicoectomy techniques and incorporates high magnification, ultrasonic root‐end preparation and root‐end filling with biocompatible filling materials. Modern endodontic surgery uses the dental operating microscope, incorporates cone‐beam computed tomography (CBCT) for preoperative diagnosis and treatment planning, and has adopted piezoelectric approaches to osteotomy and root manipulation. Crown and root resection techniques have benefitted from the same technological advances. This review focuses on the current state of root‐end surgery by comparing the techniques and materials applied during endodontic microsurgery to the most widely used earlier methods and materials. The most recent additions to the clinical protocol and technical improvements are discussed, and an outlook on future directions is given. Whilst nonsurgical retreatment remains the first choice to address most cases with a history of endodontic failure, modern endodontic microsurgery has become a predictable and minimally invasive alternative for the retention of natural teeth.
The Burden of Double Deviation in Services: A Systematic Review and Research Agenda
Authors: Suresh Priyanka , Chawla Vaibhav 
Published: June 2022

AbstractDouble deviation (failure to satisfactorily recover from a service failure) is a common phenomenon that has recently attracted significant research interest, but the academic literature lacks a study mapping and synthesizing the field. This article undertakes filling this gap by systematically reviewing the double deviation literature. The review classifies the literature into causes, consequences, moderators, and double service recovery and identifies research themes and future research directions within them. Key current research themes are ineffective recovery remedies and cognitive appraisal criteria as causes; emotivational goals, revengeful and reparative behaviours as consequences; firm–customer relationship‐based variables as moderators; and unique tactics of double service recovery. Reassessing the scope of double deviation, uncovering customers' discrete emotions during double deviation and ascertaining the commercial viability of double service recovery are some recommendations for future research.
Preparation, characterisation and in vitro digestibility of potato starch‐fatty acid complexes
Authors: Li Suhong , Wang Siyu , Wang Yanhua , Tian Yuxuan , Yu Siqi , Hu Xiaopei , Li Tuoping 
Published: June 2022

SummaryThe starch‐fatty acid (FA) complex belongs to a new type of resistant starch (RS5) and has become a prevalent research topic because of its slow‐digestion and enzymatic resistance properties. In this study, the starch‐FA complexes were prepared from potato starch (PS) and FAs with various carbon chain lengths and unsaturation by hydrothermal treatment (HT), alcohothermal treatment (AT) or ultrasound treatment (UT), and their physicochemical properties and digestibility were interpreted. The PS‐8% lauric acid (Lau) with the highest complex index value (approximately 95%) and RS content (approximately 31%) was obtained by HT; meanwhile, it had a slow glucose diffusion rate and a low free fatty acid release rate in simulated gastrointestinal digestion compared to native PS. Besides, the V‐type crystalline structure was formed obviously after HT, but it was too weak for AT and UT samples to be detected. The gelatinisation viscosity was reduced due to the physical combination of PS and Lau. Therefore, HT was a relatively efficient and safe approach to prepare starch‐FA complex with high RS content, and the obtained starch‐FA complex has the potential to become an alternative functional food ingredient.
Tecnologías de rastreo de contactos en el lugar de trabajo y marco de protección de datos de la Unión Europea: dónde está el límite
Authors: SUDER Seili , SIIBAK Andra 
Published: June 2022

ResumenSe exploran los posibles usos y riesgos en el lugar de trabajo de las aplicaciones de rastreo de contactos y otras tecnologías de vigilancia implantadas para contener la COVID‐19, tomando como referencia el Reglamento General de Protección de Datos de la Unión Europea. Dado el desequilibrio de poder inherente a la relación de trabajo, las legislaciones nacionales deberían reforzar la potestad de las y los empleados de rechazar dichas aplicaciones cuando finalice la pandemia. Serán necesarias normativas y orientaciones adicionales para evitar futuros problemas, como las desviaciones de uso de dichas tecnologías por parte de entidades empleadoras.
From Pareto to Weibull – A Constructive Review of Distributions on ℝ+
Authors: Sinner Corinne , Dominicy Yves , Trufin Julien , Waterschoot Wout , Weber Patrick , Ley Christophe 
Published: June 2022

SummaryPower laws and power laws with exponential cut‐off are two distinct families of distributions on the positive real half‐line. In the present paper, we propose a unified treatment of both families by building a family of distributions that interpolates between them, which we call Interpolating Family (IF) of distributions. Our original construction, which relies on techniques from statistical physics, provides a connection for hitherto unrelated distributions like the Pareto and Weibull distributions, and sheds new light on them. The IF also contains several distributions that are neither of power law nor of power law with exponential cut‐off type. We calculate quantile‐based properties, moments and modes for the IF. This allows us to review known properties of famous distributions on
and to provide in a single sweep these characteristics for various less known (and new) special cases of our Interpolating Family.
Meiofauna is an important, yet often overlooked, component of biodiversity in the ecosystem formed by Posidonia oceanica
Authors: García‐Gómez Guillermo , García‐Herrero Álvaro , Sánchez Nuria , Pardos Fernando , Izquierdo‐Muñoz Andrés , Fontaneto Diego , Martínez Alejandro 
Published: June 2022

AbstractThe ecosystem formed by the marine flowering plant Posidonia oceanica is a biodiversity reservoir and provides many ecosystem services in coastal Mediterranean regions. Marine meiofauna is also a major component of that biodiversity, and its study can be useful in addressing both theoretical and applied questions in ecology, evolution, and conservation. We review the meiofaunal diversity in the meadow ecosystem of P. oceanica by combining a literature review and a case study. First, we gathered records of 672 species from 71 published studies, as well as unpublished sources, highlighting 4 species exclusive to this ecosystem. Eighteen of those studies quantified the spatial and temporal changes in species composition, highlighting habitat‐specific assemblages that fluctuate following the annual changes experienced by these meadows. Hydrodynamics, habitat complexity, and food availability, all three inherently linked to the seagrass phenology, are recognized in the literature as the main factors shaping the complex distribution patterns of meiofauna in the meadows. These drivers have been identified mainly in studies of Copepoda and Nematoda, and their effect may depend ultimately on species‐specific preferences. Second, we tested the generality of these observations using marine mites as a model group, showing that similar ecological preferences might be found in other less abundant meiofaunal groups. Overall, our study highlights the high diversity of meiofauna in meadows of P. oceanica compared with algae and sessile macrofauna associated with this seagrass and shows the complexity of the interactions and habitat use by meiofauna associated with the seagrass.
A nursing socio‐environmental approach for acute pesticide poisoning: A qualitative focus group study
Authors: Rueda‐Ruzafa Lola , Ropero‐Padilla Carmen , Ruiz‐González Cristofer , Rodriguez‐Arrastia Miguel , Roman Pablo , Sánchez‐Labraca Nuria 
Published: June 2022

AbstractAimTo explore the experiences and perceptions of final‐year nursing students in assessing and managing acute pesticide poisoning using a socio‐environmental care approach in a primary health care simulation‐based scenario.DesignA qualitative descriptive study was conducted using focus groups.MethodsTwelve focus groups were held, with 114 fourth‐year nursing students. The study was carried out from September to November 2021. To grant an in‐depth analysis of the collected data, a thematic analysis was used.ResultsAfter our data analysis, three main themes emerged: (i) experiences of an acute pesticide poisoning case in a simulation‐based scenario; (ii) environmental health nursing competencies for a culturally competent practice and (iii) social factors in prevention strategies.ConclusionsUsing a socio‐environmental care approach with a primary care simulation‐based poisoning case can provide a realistic public health clinical experience for local problems and prepare the context for the development of global citizenship values, as well as offer numerous opportunities to facilitate transformative learning, including Sustainable Development Goals (SDGs) into local nursing clinical practice.ImpactNurse managers, policymakers and educators must collaborate together to broaden their reach in teaching the role of the environment and social determinants of health through evidence‐based care models, as well as actively contributing to the achievement of the SDGs to promote “glocal” competencies among nursing professionals.
Transseptal puncture for left atrial ablation: Risk factors for cardiac tamponade and a proposed causative classification system
Authors: Maclean Edd , Mahtani Karishma , Roelas Marina , Vyas Rohan , Butcher Charles , Ahluwalia Nikhil , Honarbakhsh Shohreh , Creta Antonio , Finlay Malcolm , Chow Anthony , Earley Mark , Sporton Simon , Lowe Martin , Sawhney Vinit , Ezzat Vivienne , Ahsan Syed , Khan Fakhar , Dhinoja Mehul , Lambiase Pier , Schilling Richard , Hunter Ross , Segal Oliver 
Published: June 2022

AbstractAimsCardiac tamponade is a high morbidity complication of transseptal puncture (TSP). We examined the associations of TSP‐related cardiac tamponade (TRCT) for all patients undergoing left atrial ablation at our center from 2016 to 2020.Methods and ResultsPatient and procedural variables were extracted retrospectively. Cases of cardiac tamponade were scrutinized to adjudicate TSP culpability. Adjusted multivariate analysis examined predictors of TRCT. A total of 3239 consecutive TSPs were performed; cardiac tamponade occurred in 51 patients (incidence: 1.6%) and was adjudicated as TSP‐related in 35 (incidence: 1.1%; 68.6% of all tamponades). Patients of above‐median age [odds ratio (OR): 2.4 (1.19–4.2), p = .006] and those undergoing re‐do procedures [OR: 1.95 (1.29–3.43, p = .042] were at higher risk of TRCT. Of the operator‐dependent variables, choice of transseptal needle (Endrys vs. Brockenbrough, p > .1) or puncture sheath (Swartz vs. Mullins vs. Agilis vs. Vizigo vs. Cryosheath, all p > .1) did not predict TRCT. Adjusting for operator, equipment and demographics, failure to cross the septum first pass increased TRCT risk [OR: 4.42 (2.45–8.2), p = .001], whilst top quartile operator experience [OR: 0.4 (0.17–0.85), p = .002], transoesophageal echocardiogram [TOE prevalence: 26%, OR: 0.51 (0.11–0.94), p = .023], and use of the SafeSept transseptal guidewire [OR: 0.22 (0.08–0.62), p = .001] reduced TRCT risk. An increase in transseptal guidewire use over time (2016: 15.6%, 2020: 60.2%) correlated with an annual reduction in TRCT (R2 = 0.72, p < .001) and was associated with a relative risk reduction of 70%.ConclusionsDuring left atrial ablation, the risk of TRCT was reduced by operator experience, TOE‐guidance, and use of a transseptal guidewire, and was increased by patient age, re‐do procedures, and failure to cross the septum first pass.
The European Semester: An Ordoliberal Construct?
Authors: Argyroulis Dimitrios 
Published: June 2022

AbstractThe outbreak of the COVID‐19 pandemic appears to have inflicted a decisive blow to ordoliberalism's influence on the economic governance of the Eurozone. This contribution shows that the decline of the ordoliberal ideas precedes the pandemic and can be traced in the management of the financial crisis of 2007–2009. Drawing on the theoretical approach of sociological institutionalism and using insights from 18 interviews with participants in the Economic and Financial Committee and the ECOFIN, this article analyses the evolution of policy‐makers' economic policy beliefs and their impact on the fiscal reform of 2010–2013. It is argued that the establishment of the European Semester was the institutional reflection of an intellectual shift from rules‐based to institutions‐based discipline. I find that the latter conflicts with core ordoliberal principles of the Freiburg economic school, opening the way for alternative institutional arrangements, such as the Recovery and Resilience Facility.
Soft sensor with deep feature extraction for a sugarcane milling system
Authors: Meng Yanmei , Chen Jie , Li Zhengyuan , Zhang Yue , Liang Lisheng , Zhu Jihong 
Published: June 2022

AbstractExtraction rate and energy consumption are two important indicators of the sugarcane milling system, which are calculated by offline experiments and inspection methods. Soft sensors are inferential models, which are enabling online prediction of these indicators. Selection of input variables is one of the most critical issues in soft sensors design. So a deep feature extraction method is proposed by combining mutual information theory and hybrid chicken swamp algorithm to determine the input and parameters of model. Then, input the obtained variables into the data‐driven model of deep kernal extreme learning machine (DK‐ELM) with optimized parameters to realize the prediction of extraction and hourly energy consumption. It combines the kernel method with the multi‐layer ELM. Experiments are conducted to verify the effectiveness and superiority of the modeling method. Comparing the proposed framework with the four experiments designed on a sugarcane milling system, the proposed framework for predicting extraction and energy consumption with better feasibility and effectiveness, and provided a good reference for end‐point control and judgment of quick direct tapping.Practical ApplicationsExtraction and energy consumption are two important indicators of the milling process and whether they meet standards will affect the smooth operation and economic benefits of sugar production. This study presents a novel modeling method to predict these indicators based on the deep feature extraction and deep kernal extreme learning machine. These methods provided a good reference for end‐point control and judgment of quick direct tapping. In addition, it a new concept for the design of soft sensors for such complex industrial processes.
End‐of‐life healthcare utilization and palliative care use among older adults with limited English proficiency
Authors: Abedini Nauzley C. , Downey Lois , Engelberg Ruth A. , Curtis J. Randall , Sharma Rashmi K. 
Published: June 2022

AbstractBackgroundLittle is known about end‐of‐life healthcare utilization and palliative care use among older adults with serious illness and limited English proficiency (LEP).MethodsWe conducted a retrospective analysis of seriously‐ill older adults (65+) with and without LEP, from a large health system, who died between 2010 and 2018. Primary outcomes were measures of healthcare utilization in the last 30 and 180 days of life: hospitalization, emergency department (ED) visits, intensive care unit (ICU) admission, and 30‐day readmission. Secondary outcomes were palliative care consultation and advance care planning documents. We used multivariate analyses adjusted for sociodemographic factors including race and ethnicity.ResultsAmong 18,490 decedents, 1363 had LEP. Patients with LEP were older at time of death (median age 80 vs 77 years), more likely to be female (48% vs 44%), of Asian descent (64% vs 4%), of Hispanic ethnicity (10% vs 2%), with <12th grade education (38% vs 9%), and Medicaid (36% vs 6%). In the last 30 days of life, patients with LEP had higher odds of ED visits (33% vs 20%; aOR 1.41, 95% CI 1.26–1.72; p < 0.001), readmission (12% vs 8%; aOR 1.64, 95% CI 1.30–2.07; p < 0.001), and in‐hospital death (45% vs 37%; aOR 1.24, 95% CI 1.07–1.44; p = 0.005) compared to patients without LEP. Findings were similar in the last 180‐days of life. Only 14% of patients with LEP and 10% of those without LEP received palliative care consultation in the last month of life. Patients with LEP were less likely to have advance care planning documents than patients without LEP (36% vs 40%; aOR 0.68, 95% CI 0.50–0.80; p < 0.001).ConclusionsOlder adults with serious illness and LEP have higher rates of end‐of‐life healthcare utilization. Additional research is needed to identify drivers of these differences and inform linguistically‐ and culturally‐appropriate interventions to improve end‐of‐life care in this population.