bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic transorbital approach to the cavernous sinus: Cadaveric anatomy study and clinical application (‡SevEN-009)
Authors: Jung In-Ho , Yoo Jihwan , Choi Seonah , Lim Seung Hoon , Ko JaeSang , Roh Tae Hoon , Hong Je Beom , Kim Eui Hyun 
Published: August 2022

ObjectiveCavernous sinus (CS) invasion is frequently encountered in the management of skull base tumors. Surgical treatment of tumors in the CS is technically demanding, and selection of an optimal surgical approach is critical for maximal tumor removal and patient safety. We aimed to evaluate the feasibility of an endoscopic transorbital approach (ETOA) to the CS based on a cadaveric study.MethodsFive cadaveric heads were used for dissection under the ETOA in the comparison with the endoscopic endonasal approach (EEA) and the microscopic transcranial approach (TCA). The CS was exposed, accessed, and explored, first using the ETOA, followed by the EEA and TCA. A dedicated endoscopic system aided by neuronavigation guidance was used for the procedures. During the ETOA, neurovascular structures inside the CS were approached through different surgical triangles.ResultsAfter completing the ETOA with interdural dissection, the lateral wall of the CS was fully exposed. The lateral and posterior compartments of the CS, of which accessibility is greatly limited under the EEA, were effectively approached and explored under the ETOA. The anteromedial triangle was the largest window via which most of the lateral compartment was freely approached. The internal carotid artery and abducens nerve were also observed through the anteromedial triangle and just behind V1. During the ETOA, the approaching view through the supratrochlear and infratrochlear triangles was more directed towards the posterior compartment. After validation of the feasibility and safety based on the cadaveric study, ETOA was successfully performed in a patient with a pituitary adenoma with extensive CS invasion.ConclusionsBased on the cadaveric study, we demonstrated that the lateral CS wall was reliably accessed under the ETOA. The lateral and posterior compartments of the CS were effectively explored via surgical triangles under the ETOA. ETOA provides a unique and valuable surgical route to the CS with a promising synergy when used with EEA and TCA. Our experience with a clinical case convinces us of the efficacy of the ETOA during surgical management of skull base tumors with CS-invasion.
Case report: Novel compound heterozygous missense mutations in the DDHD2 gene in a Chinese patient associated with spastic paraplegia type 54
Authors: Xu Xin , Lu Fen , Du Senjie , Zhao Xiaoke , Li Hongying , Zhang Li , Tang Jian 
Published: August 2022

BackgroundSpastic paraplegia type 54 (SPG54) is a rare inherited autosomal recessive disorder, and a complex hereditary spastic paraplegia (HSP) caused by mutations in the phospholipase DDHD2 gene. SPG54 is characterized by early onset of spastic paraplegia, intellectual disability and dysplasia of corpus callosum.Case presentationWe report a 9 years and 5 months old Chinese girl with progressive spasm of the lower limbs, muscle weakness and intellectual disability. Brain magnetic resonance imaging (MRI) showed periventricular leukomalacia and thinning of the corpus callosum. According to the Wechsler Intelligence Scale, her IQ is 42. By whole exome sequencing, novel compound heterozygous missense mutations in the DDHD2 gene [c.168G&gt;C, p.(Trp56Cys) and c.1505T&gt;C, p.(Phe502Ser)] were identified in the proband. Comparative amino acid sequence alignment across different species revealed that Trp56 and Phe502 in the DDHD2 protein were highly conserved during evolution. And multiple in silico prediction tools suggested that both mutations were deleterious.ConclusionsOur study reports a very rare case of complicated HSP caused by two novel compound heterozygous mutations in the DDHD2 gene. Our findings expand the genetic spectrum of SPG54.
Examination on the risk factors of cholangiocarcinoma: A Mendelian randomization study
Authors: Chen Lanlan , Fan Zhongqi , Sun Xiaodong , Qiu Wei , Mu Wentao , Chai Kaiyuan , Cao Yannan , Wang Guangyi , Lv Guoyue 
Published: August 2022

Background: Several risk factors have been identified for CCA, however, whether such associations were causal remains unknown.Methods: Mendelian randomization (MR) has been applied to examine the causal relationship between 26 putative risk factors and CCA. The genetic variants for each risk factor were extracted from their corresponding genome-wide association study (GWAS) if they reached the genome-wide significance (p-value &lt; 5 × 10−8). The genetic associations with CCA were obtained from the publicly available GWAS with the largest sample size. Mainly, inverse-variance weighted (IVW) has been adopted to estimate the causal effect on CCA. Both multivariable and mediation MR analyses were carried out to detect independent factors.Results: Three putative risk factors can causally elevate the risk of CCA after FDR correction, including liver fat content (LFC), non-alcoholic fatty liver disease (NAFLD), and cholelithiasis. The odds of CCA would increase per 1-SD increase in the liver fat content (LFC) (OR = 2.12 [1.66, 2.71]) and logOR of NAFLD. The genetic liability to cholelithiasis would increase the risk of CCA as well (OR = 2.17 [1.47, 3.20]). They were still significant in other methods. The multivariable MR analysis indicated that genetically-elevated LFC should increase the risk of CCA independently of cholelithiasis (OR = 1.88 [1.39, 2.55]). In the mediation MR analysis, the indirect effect was not significant when treating cholelithiasis as the mediator (indirect OR = 0.95 [0.85, 1.07]).Conclusion: This MR study identified that gallstone and liver fat accumulation are two independent risk factors of CCA, suggesting two modifiable ways of preventing CCA.
Pharmacokinetic and pharmacodynamic similarity evaluation between an insulin glargine biosimilar product and Lantus® in healthy subjects: Pharmacokinetic parameters of both parent insulin glargine and M1 were used as endpoints
Authors: Wang Yiya , Zhou Ying , Ding Juefang , Li Xianjing , Guo Fengxue , Zhang Jianfei , Ding Li 
Published: August 2022

Insulin glargine is a long-acting insulin analog, which plays an important role in the treatment of diabetes mellitus. Biosimilar products of insulin glargine can provide patients with additional safe, high-quality, and potentially cost-effective options for treating diabetes. This article presents a randomized, double-blind, single-dose, two-treatment, four-period, replicate crossover, euglycemic clamp study which was designed to evaluate the PK and PD similarity between the recombinant insulin glargine developed by Wanbang (test) and Lantus® (reference) in healthy volunteers. Subjects received subcutaneous administration of the insulin glargine formulation (0.4 U/kg) on two occasions for the test and reference drug, respectively, and a 20% dextrose solution was infused at variable rate to clamp the blood glucose concentrations at 0.3 mmol/L below the subjects’ fasting glucose for 24 h. Taking advantage of the improved sensitivity of the bioanalytical method applied and the solution of the matrix stability problem, the parent insulin glargine was determined in the vast majority of plasma samples using a fully validated UHPLC-MS/MS method. The PK characteristics of the parent insulin glargine were revealed for the first time: after subcutaneous injection, concentrations of the parent insulin glargine increased to a relative high level within 3 h, and then, a relatively flat concentration–time profile lasting for at least 12 h post-dose was observed. For the first time, the pharmacokinetic parameters of the parent insulin glargine were used as endpoints for similarity evaluation, which complied with the regulatory guidance better and made the similarity conclusion more powerful. The ratios of geometric means of all PK and PD endpoints were close to 100.00%. For the PK endpoints (AUC0–24h, Cmax, AUC0–12h, and AUC12–24h of the parent insulin glargine and its metabolite M1), the 90% confidence intervals of geometric mean ratios of test to reference were entirely contained within 80.00%–125.00%. For the PD endpoints [AUCGIR(0–24h), GIRmax, AUCGIR(0–12h), and AUCGIR(12–24h)], the 95% confidence intervals of geometric mean ratios of test to reference were entirely contained within 80.00%–125.00%. Based on the above mentioned results, it can be concluded that the PK and PD characteristics of the biosimilar drug developed by Wanbang are similar to those of Lantus.
Application of physiologically-based pharmacokinetic/pharmacodynamic models to evaluate the interaction between nifedipine and apatinib
Authors: Liu Hongrui , Yu Yiqun , Liu Lu , Wang Chunyan , Guo Nan , Wang Xiaojuan , Xiang Xiaoqiang , Han Bing 
Published: August 2022

Aim: It has been found that the co-administration of nifedipine with apatinib could cause exposure changes of nifedipine in vivo. But, whether this pharmacokinetic drug-drug interaction (DDI) between nifedipine and apatinib could enhance the antihypertensive effect of nifedipine, causing sever changes of blood pressure was unknown. Therefore, the aim of the present study was to conduct the pharmacokinetic/pharmacodynamic (PK/PD) modelling to evaluate the effect of pharmacokinetic changes on the antihypertensive effect of nifedipine. Thus, the results could guide the co-administration of these two drugs in clinic.Methods: A physiologically-based pharmacokinetic (PBPK) model was first developed for nifedipine. The pharmacokinetic DDI between nifedipine and apatinib was evaluated. Then the verified PBPK models were linked to a PD model for investigating whether the exposure changes of nifedipine could cause severe changes in blood pressure. Furthermore, the changes in blood pressure caused by combination with apatinib were also assessed in patients with hepatic impairment via the PBPK/PD models.Results: The predicted area under plasma concentration-time profile (AUC), maximum concentration (Cmax), area under effect-time profile (AUE), and maximum reduction in systolic blood pressure (Rmax) are all within 0.5–2.0-fold of the observed data, indicating that the PBPK/PD models for nifedipine are successfully established. The increases of predicted AUC and Cmax of nifedipine in the presence of apatinib are 1.73 and 1.41-fold, respectively. Co-administration of nifedipine with apatinib could cause exposure changes of nifedipine in vivo. However, the predicted AUE and Rmax changes of nifedipine in the presence to the absence of apatinib in cancer patients as well as in patients with hepatic impairment are all within 1.25-fold. The results indicate that the exposure changes of nifedipine caused by combination of apatinib has little effect on the changes of systolic blood pressure both in cancer patients and patients with hepatic impairment.Conclusion: The pharmacokinetic changes of nifedipine caused by co-administration with apatinib has little impact on the antihypertensive effect of nifedipine. Apatinib is unlikely to cause severe pharmacodynamic DDI via inhibition of CYP3A4. It is suggested that nifedipine could be used in combination with apatinib without dose adjustment in clinic.
Ethnic and migration-related inequalities in health anxiety: A systematic review and meta-analysis
Authors: Barbek Rieke , Henning Sinje , Ludwig Julia , von dem Knesebeck Olaf 
Published: August 2022

BackgroundHealth anxiety exists on a continuum ranging from the absence of health awareness to the obsessive fear of having a serious illness despite reassurance. Its pathological manifestation can be diagnosed as hypochondriacal or illness anxiety or somatic symptom disorder. Health anxiety is associated with psychological distress and adverse life events, among others, and leads to considerable economic burden. Compared to the majority population, migrants, and ethnic minorities often face major health inequalities. Several mental illnesses and psychosomatic complaints are more common among these groups. To date, potential ethnic and migration-related inequalities in health anxiety have not been clearly described. However, they are of high relevance for the provision of adequate health care of this diverse and potentially vulnerable group. Thus, we conducted a systematic review and meta-analysis of health anxiety in migrants and ethnic minorities.MethodsA systematic literature search of PubMED, Web of Science, PsycINFO, and PSYNDEX was conducted, covering all studies published until 1st of December 2021. Studies were selected if they employed validated measurement tools of health anxiety and examined migrants and/or ethnic minorities in comparison with the majority population. Meta-analytic methods were applied by using a random-effect model. The study quality was assessed with the Effective Public Health Practice Project Quality Assessment Tool (EPHPP).ResultsWe identified 18 studies from 445 studies initially screened. Of these, 14 studies conducted in North America with a total number of 5,082 study participants were included in the meta-analysis. The pooled effect size indicated a higher risk of health anxiety in migrants and ethnic minorities compared to the majority population (OR 1.39, 95%-CI 1.01–1.92). The results proved not to be robust according to publication bias (adjusted OR 1.18, 95%-CI 0.83–1.69) and fail-safe N (2/3 &lt; benchmark N = 75) and are limited due to heterogeneity (I2 = 57%), small sample sizes and an overall low quality of included studies.ConclusionTo address the diversity of migrants and ethnic minorities, inter-sectional approaches across different countries are needed in research to shed further light on social inequalities in health anxiety linked to migration.Systematic review registrationPROSPERO, registration number CRD42022298458.
Prognostic nomograms for gastric carcinoma after surgery to assist decision-making for postoperative treatment with chemotherapy cycles <9 or chemotherapy cycles ≥9
Authors: Li Yifan , Zhang Xiaojuan 
Published: August 2022

ObjectiveWe sought to develop novel nomograms to accurately predict overall survival (OS) of chemotherapy cycles &lt;9 and chemotherapy cycles ≥9 and construct risk stratification to differentiate low-risk and high-risk of two cohorts.MethodsPatients who underwent curative-intent resection for gastric cancer between January 2002 and May 2020 at a single China institution were identified. Variables associated with OS were recorded and analyzed according to multivariable Cox models. Nomograms predicting 3- and 5-year OS were built according to variables resulting from multivariable Cox models. Discrimination ability was calculated using the Harrell's Concordance Index. The constructed nomogram was subjected to 1,000 resamples bootstrap for internal validation. Calibration curves for the new nomograms were used to test the consistency between the predicted and actual 3- and 5-year OS. Decision curve analysis (DCA) was performed to assess the clinical net benefit. The Concordance index (C-index) and time-dependent receiver operating characteristic (t-ROC) curves were used to evaluate and compare the discriminative abilities of the new nomograms. Finally, prognostic risk stratification of gastric cancer was conducted with X-tile software and nomograms converted into a risk-stratified prognosis model.ResultsFor the nomogram predict OS of chemotherapy cycles &lt;9, C-index was 0.711 (95% CI, 0.663–0.760) in internal validation and 0.722 (95% CI, 0.662–0.783) in external validation, which was better than AJCC 8th edition TNM staging (internal validation: 0.627, 95% CI, 0.585–0.670) and (external validation: 0.595,95% CI, 0.543–0.648). The C-index of the nomogram for chemotherapy cycles ≥9 in internal validation was 0.755 (95% CI, 0.728–0.782) and 0.785 (95% CI, 0.747–0.823) in external validation, which was superior to the AJCC 8th edition TNM staging (internal validation: 0.712 95% CI, 0.688–0.737) and (external validation 0.734, 95% CI, 0.699–0.770).The calibration curves, t-ROC curves and DCA of the two nomogram models show that the recognition performance of the two nomogram models was outstanding. The statistical differences in the prognosis among the two risk stratification groups further showed that our model had an excellent risk stratification performance.ConclusionThis is first reported risk stratification for chemotherapy cycles of gastric carcinoma. Our proposed nomograms can effectively evaluate postoperative prognosis of patients with different chemotherapy cycles of gastric carcinoma. Chemotherapy cycles ≥9 is therefore recommended for high-risk patients with chemotherapy cycles &lt;9, but not for low-risk patients. Meanwhile, combination with multiple therapies are essential to high-risk patients with chemotherapy cycles ≥9 and unnecessary for low-risk patients.
Mindfundless en atletas de alto rendimiento
Authors: García-Álvarez Aída Dinorah , Suarez-Jiménez Rosario del Carmen , Rebollo-Meza Jorge 
Published: August 2022

El mundo deportivo cuenta con un carácter multidimensional que requiere habilidades físicas y psicológicas para mejorar y optimización el rendimiento de los atletas, el mindfulness o atención plena funciona como una alternativa efectiva en el control de los eventos internos de un atleta de alto rendimiento al prestar atención al momento presente por medio de la apertura a las experiencias como una vivencia en sí misma.
En este artículo se busca destacar la importancia de una preparación psicológica con técnicas de mindfulness, la cual surge debido a que el objetivo del mindfulness no consiste como tal en tratar de controlar los pensamientos, sensaciones o sentimientos de los atletas, tampoco en modificarlos o cambiarlos, sino que permite dejarlos fluir libremente aceptando cualquier pensamiento, sentimiento, emoción o sensación fisiológica que pueda aparecer de forma espontánea y a su vez enseñar a los usuarios a mantener la concentración en lo que debe hacer en el momento de acuerdo a lo que ocurra sin pensar en lo que fue o pudo haber sido, y pensar en su experiencia presente.
Los beneficios que este tipo de preparación trae y que un entrenador provee a través del mindfulness, la motivación y los seguimientos oportunos son: la salud mental, la salud emocional, la salud física, y el aumento en el rendimiento deportivo de los atletas de alto rendimiento.
Gambaran Hasil Pengukuran Tekanan Darah Antara Posisi Klien Duduk dengan Berbaring di Desa Sambitan Kecamatan Pakel Kabupaten Tulungagung
Authors: YULIASTUTI WIWID , Prastyo Dwi Bagus , Aurellia Salsabilla 
Published: August 2022

Tekanan darah merupakan ukuran yang dapat menentukan seberapa kuat jantung memompa darah ke seluruh tubuh. Tekanan darah sendiri dapat dipengaruhi oleh beberapa faktor, seperti gaya hidup seseorang, usia, aktivitas yang dijalani, hingga emosi yang tengah dirasakan. Bahkan, tekanan darah dapat ditentukan dari jenis kelamin dan peningkatan seiring bertambahnya usia.. Jika pengukuran tekanan darah tidak dilakukan dengan benar, bisa salah diagnosis sebagai hipertensi. Tujuan dari penelitian ini adalah untuk mengetahui gambaran hasil pengukuran tekanan darah klien di Desa Sambitan Kecamatan Pakel Kabupaten Tulungagung dalam posisi duduk dan berbaring. Populasi dalam penelitian ini adalah 77 klien yang berdomisili di , Desa Sambitan, Kecamatan Pakel, Kabupaten Tulungagung. Sampel untuk penelitian ini termasuk 30 pasien. Metode analisis data yang digunakan adalah uji statistik “Paired T Test”. Hasil penelitian ini menunjukkan bahwa pengukuran tekanan darah pada posisi duduk menunjukkan nilai sistolik rata-rata 127 mmHg dan nilai diastolik 78 mmHg, dan pengukuran tekanan darah pada posisi berbaring menunjukkan nilai sistolik rata-rata 125 mmHg dan nilai diastolik. 75 mmHg. Dari hasil analisis diperoleh p(0,000)<α(0,05), maka Ho ditolak dan H1 diterima. Yang artinya "ada perbedaan hasil pengukuran tekanan darah antara posisi klien duduk dengan berbaring di Desa Sambitan Kecamatan Pakel Kabupaten Tulungagung".Kesimpulannya terdapat perbedaan hasil pengukuran tekanan darah antara posisi duduk dengan berbaring. Hasil pengukuran tekanan darah posisi berbaring lebih rendah dari pada posisi duduk
Is telemedicine a golden opportunity or a dangerous roundabout for chronic rheumatic diseases? A narrative review
Authors: Melis Maria Ramona , El Aoufy Khadija , Matucci-Cerinic Marco 
Published: August 2022

Introduction: Telemedicine (TM) reported a great increase from 50% to 150% in health care to RMDs patients during the COVID-19 period, but conflicting opinions in the literature are still present.
Aim: to investigate the results of literature on TM in terms of feasibility (patients’ satisfaction, accessibility, clinical outcomes and barriers), discussing its integration for the future in a nursing perspective during and after COVID-19 period.
Methods: the team that conducted the narrative review was composed by two rheumatology and research nurses (MRM, KEA) and a rheumatologist (MMC), who discussed the relevance of the research question and agreed on the search strategy. Pubmed and Google Scholar databases were searched. The inclusion criteria were: original and quantitative research papers in English with available abstract/full text, on adult patients with RMDs in accordance with the American College of Rheumatology (ACR) and/or European Alliance of Associations of Rheumatology (EULAR) classification criteria, exposed to any kind of technologies during and after COVID19 period, investigating any kind of patient/clinical reported outcomes.
Results: TM could be considered as an integration to standard clinical care in Rheumatology, especially for patients with a stable or low disease activity and rheumatic diagnosis. The choice of the candidates and the assessment of their E-health literacy level are necessary prior including them in TM programs. In addition, healthcare professionals need to be trained in this new modality of providing care.
Conclusion: hybrid models of telehealthcare might be a balanced solution, improving efficiency of the consultation, continuity of care and providing a patient-centred approach.
The Relationship Between Obstetric Factors and Postpartum Haemorrhage Maternal Deaths in Jember District
Authors: Gayatri Mergy , Pratiwi Dyah Krisnawati Satia , Pratiwi Nanda Agnesia Jati , Sutrisno Sutrisno , Arsana I Wayan Agung 
Published: August 2022

Maternal mortality remains public health issue. One of its leading causes is postpartum haemorrhage. The aim of this study is to test the relationship between haemoglobin levels, perineal tear, retained placenta, uterine atony, and maternal mortality from postpartum haemorrhage in Jember district, Indonesia. This case-control study comprised 43 mothers died from postpartum haemorrhage (cases), and 43 mothers survived from postpartum haemorrhage (controls) between from January 2017 and December 2019. Data were obtained from maternal verbal autopsies, complemented by birth registrations and medical records in 26 community health centres across Jember district. The chi-square, and multivariate logistic regression were administered to test the hypothesis. The results of this study indicate that Haemoglobin levels (p = 0.032, OR 6.372, 95% CI 1.172 - 34.626), retained placenta (p = 0.033, OR 4.578 95% CI 1.128 – 18.587), and atonia utery (p= 0.014, OR 4.578 95% 1.364 – 16.502) had significant relationship with maternal deaths from postpartum haemorrhage. However, perineal tear (p= 0.155, OR 0.347 95% 0.081 – 1.490) had no significant relationship with maternal deaths from postpartum haemorrhage. The conclusion in this study is Identifying obstetric factors are important. Therefore, conducting early detection screening during pregnancy is encouraged to reduce postpartum haemorrhage maternal death.