bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is early exposure to cannabis associated with bipolar disorder? Results from a Finnish birth cohort study
Authors: Denissoff Alexander , Mustonen Antti , Alakokkare Anni‐Emilia , Scott James G. , Sami Musa B. , Miettunen Jouko , Niemelä Solja 
Published: March 2022

AbstractBackground and aimsThere are few longitudinal studies assessing the association of cannabis use and subsequent onset of bipolar disorder. We aimed to measure the association between early cannabis exposure and subsequent bipolar disorder.Design, Setting and ParticipantsObservational study linking a sample from the northern Finland birth cohort 1986 (n = 6325) to nation‐wide register data to examine the association of life‐time cannabis exposure at age 15/16 years and subsequent bipolar disorder until age 33 (until the end of 2018); 6325 individuals (48.8% males) were included in the analysis.MeasurementsCannabis exposure was measured via self‐report. Bipolar disorder was measured via bipolar disorder‐related diagnostic codes (ICD‐10: F30.xx, F31.xx) collected from the Care Register for Health Care 2001–18, the Register of Primary Health Care Visits 2011–18, the medication reimbursement register of the Social Insurance Institution of Finland 2001–05 and the disability pensions of the Finnish Center for Pensions 2001–16. Potential confounders included demographic characteristics, parental psychiatric disorders, emotional and behavioral problems and other substance use.FindingsThree hundred and fifty‐two adolescents (5.6%) reported any cannabis use until the age of 15–16 years. Of the whole sample, 66 (1.0%) were diagnosed with bipolar disorder. Adolescent cannabis use was associated with bipolar disorder [hazard ratio (HR) = 3.46; 95% confidence interval (CI) = 1.81–6.61]. This association remained statistically significant after adjusting for sex, family structure and parental psychiatric disorders (HR = 3.00; 95% CI = 1.47–6.13) and after further adjusting for adolescent emotional and behavioral problems (HR = 2.34; 95% CI = 1.11–4.94). Further adjustments for frequent alcohol intoxications, daily smoking and lifetime illicit drug use attenuated the associations to statistically non‐significant.ConclusionsIn Finland, the positive association between early cannabis exposure and subsequent development of bipolar disorder appears to be confounded by other substance use.
Videofluoroscopy compared with clinical feeding evaluation in children with suspected aspiration
Authors: Stafler Patrick , Akel Khaled , Eshel Yuliana , Shimoni Adi , Grozovski Sylvia , Mei‐Zahav Meir , Levine Hagit , Gendler Yulia , Blau Hannah , Prais Dario 
Published: March 2022

AbstractAimVideofluoroscopy swallow studies (VFSS) are gold standard to diagnose aspiration in children but require resources and radiation compared with clinical feeding evaluation (CFE). We evaluated their added value for diagnosis, feeding management and clinical status.MethodsA retrospective single‐centre cross‐sectional study of children aged 0–18 years, with respiratory morbidity, referred for VFSS at a tertiary pediatric hospital.ResultsA total of 113 children, median age (range) 2.2 years (0.1–17.9), underwent VFSS. Diagnosis included chronic pulmonary aspiration (CPA), 87 (77%); neurological, 73 (64%); gastrointestinal, 73 (64%) and congenital heart disease, 42 (37%), not mutually exclusive. Forty‐six (41%) aspirated, 9 (8%) only overtly and 37 (33%) including silent aspirations. Those with CPA or cerebral palsy were more likely to have VFSS aspiration, OR 3.2 and 9.8 respectively.Feeding recommendations after VFSS differed significantly from those based on prior CFE, p < 0.001: The rate of exclusively orally fed children rose from 65% to 79%, p = 0.006; exclusively enterally fed children from 10% to 14%; p = 0.005. During the year after VFSS, there were significantly less antibiotic courses, total and respiratory admissions.ConclusionIn this population with high prevalence of clinically suspected CPA, VFSS altered feeding management compared with CFE and may have contributed to subsequent clinical improvement.
Predicting factors of clinically significant urological anomalies after initial urinary tract infection among 2‐ to 24‐month‐old children
Authors: Banno Yoshinori , Sugiyama Takehiro 
Published: March 2022

AbstractAimTo find more effective criteria to identify clinically significant urological anomalies after initial urinary tract infection among children.MethodsChildren aged 2–24 months with an initial urinary tract infection were consecutively recruited in a Japanese hospital from 2013 to 2019. Voiding cystourethrography, 99mTc dimercaptosuccinic acid scan and ultrasound were intended to perform for all cases. Clinically significant urological anomalies were defined as high‐grade vesicoureteral reflux, obstructive and abnormal urinary tract lesions, need for surgical intervention, renal hypoplasia and scarring. Using classification and regression tree analysis, we sought the associated factors. We developed new criteria with these factors, retrospectively applied them to the original data, and calculated the sensitivity and specificity.ResultsOne hundred sixty‐seven patients were eligible, and 39 had clinically significant urological anomalies. Classification and regression tree analysis showed that the associated factors were non‐E. coli infections, serum creatinine levels and ultrasound abnormalities. When the gold standards were performed on children with non‐E. coli infections or serum creatinine levels ≥0.21 mg/dl, sensitivity and specificity were 0.82 and 0.68, respectively.ConclusionThe criteria including non‐E. coli infections and high‐normal or higher serum creatinine levels may efficiently predict clinically significant urological anomalies after initial urinary tract infections.
Mental health prior to and during the COVID‐19 pandemic in individuals with bipolar disorder: Insights from prospective longitudinal data
Authors: Lewis Katie J. S. , Gordon‐Smith Katherine , Saunders Kate E. A. , Dolman Clare , South Matthew , Geddes John , Craddock Nick , Di Florio Arianna , Jones Ian , Jones Lisa 
Published: March 2022

AbstractObjectivesMany studies have examined the impact of COVID‐19 on the mental health of the public, but few have focused on individuals with existing severe mental illness with longitudinal data before and during the pandemic. Aims: To investigate the impact of the COVID‐19 pandemic on the mental health of people with bipolar disorder (BD).MethodsIn an ongoing study of people with BD who used an online mood monitoring tool, True Colours, 356 participants provided weekly data on their mental health. Symptoms of depression, mania, insomnia, and suicidal thoughts were compared in 2019 and 2020. From May 2020, participants also provided weekly data on the effect of the COVID‐19 pandemic on anxiety, coping strategies, access to care, and medications.ResultsOn average, symptoms of depression, mania, insomnia, and suicidal thoughts did not significantly differ in 2020 compared to 2019, but there was evidence of heterogeneity. There were high rates of anxiety about the pandemic and its impact on coping strategies, which increased to over 70% of responders in January 2021. A significant proportion of participants reported difficulty accessing routine care (27%) and medications (21%).ConclusionsAlthough mood symptoms did not significantly increase during the pandemic overall, we observed heterogeneity among our BD sample and other impacted areas. Individuals' unique histories and psychosocial circumstances are key and should be explored in future qualitative studies. The significant impacts of the pandemic may take time to manifest, particularly among those who are socioeconomically disadvantaged, highlighting the need for further long‐term prospective studies.
Pathogenic variant‐based preconception carrier screening in the Israeli Jewish population
Authors: Davidov Bella , Levon Amit , Volkov Hadas , Orenstein Naama , Karo Racheli , Fatal Gazit Inbal , Magal Nurit , Basel‐Salmon Lina , Golan Mashiach Michal 
Published: March 2022

AbstractPreconception carrier screening allows identification of couples at risk to have offspring with autosomal recessive and X‐linked disorders. In a current multiethnic world, screening based on self‐reported ancestry has limitations. Here we describe the findings of a comprehensive pan‐ethnic variant‐based carrier screening, using the Israeli Jewish population as a model. The cohort included 1696 individuals (848 couples) tested with the ‘MyScreen’ multigene panel. The panel covers 1206 variants spanning 385 genes, known in different Jewish ethnicities and local Arab, Druze and Bedouin populations. Out of these, 205 variants in 143 genes are Jewish founder variants. We identified 859 (50.6%), carriers of at least one variant in 151 genes. Importantly, 569 (66.2%) of carriers could be missed by the current Israeli screening program. In total, 1:40 (2.5%) of carrier couples were identified by the ‘MyScreen’ panel, compared with 1:144 (0.7%) found by the ethnicity‐based screening. Surprisingly, 90 individuals (10.5%) were carriers of variants “unexpected” for their reported origin, and 16 variants were previously unreported in Jewish patients. Our results support the advantages of variant‐based comprehensive carrier screening for detection of carriers and at‐risk couples in a diverse population with many founder disease‐causing variants.
Effect of lateral bone augmentation procedures in correcting peri‐implant bone dehiscence and fenestration defects: A systematic review and network meta‐analysis
Authors: Severi Mattia , Simonelli Anna , Farina Roberto , Tu Yu‐Kang , Lan Cheng‐Hsiang , Shih Ming‐Chieh , Trombelli Leonardo 
Published: March 2022

AbstractPurposeThe aim of the present systematic review was to evaluate the effect of different lateral bone augmentation (LBA) procedures on the complete correction of a peri‐implant bone dehiscence (BD) or fenestration (BF) from implant placement to implant surgical uncovering.MethodsElectronic (Medline, Scopus, and Cochrane databases) and hand literature searches were performed for studies including at least one treatment arm where any LBA had been applied to correct a BD/BF at implant placement (T0). Studies where BD/BF was left untreated were also retrieved as negative control. Data from 24 selected articles were used to perform a network meta‐analysis. Based on the proportion of nonresolved BD/BF at implant surgical uncovering (T1), a hierarchy of LBA procedures, and was determined. Spontaneous healing (i.e., exposed implant surface covered by a full‐thickness flap; SELF) was also included in the hierarchy. Resorbable membrane + bone graft (RM + BG) was used as reference group. An analysis on the effect of nonhuman (NHBS) vs human (HBS) derived bone substitutes was also performed. NHBS was used as the reference group.ResultsNo statistically significant differences were found among treatments for the proportion of nonresolved BD/BF. SELF performed substantially worse compared to RM + BG (OR: 5.78 × 10, CI: 4.83 × 10 – 1.3 × 1086). Treatment based on a combination of a graft material and membrane/periosteum appeared to perform slightly better than treatments using graft material or membrane alone. NHBS appeared to perform better than HBS.SELF had the worst effect among all treatments for both BD/BF height reduction (BDH) and BD/BF width reduction (BDW). Nonresorbable membrane (NRM) and patient's own periosteum (PERI) + BG showed greater increases in buccal bone thickness than RM + BG.ConclusionReconstructive treatment (including use of graft alone, membrane alone, or combinations of grafts and either membrane or patient's own periosteum) of a BD/BF at implant placement favorably and significantly impacts on the probability to obtain complete correction of the BD/BF at implant uncovering when compared to full‐thickness flap repositioning on the BD/BF. When using a bone substitute, a nonhuman derived one may be suggested.
Microvesicles released from activated CD4+ T cells alter microvascular endothelial cell function
Authors: Vdovenko Daria , Balbi Carolina , Di Silvestre Dario , Passignani Giulia , Puspitasari Yustina M. , Zarak‐Crnkovic Martina , Mauri Pierluigi , Camici Giovanni G. , Lüscher Thomas F. , Eriksson Urs , Vassalli Giuseppe 
Published: March 2022

AbstractBackgroundMicrovesicles are vesicles shed by plasma membranes following cell activation and apoptosis. The role of lymphocyte‐derived microvesicles in endothelial function remains poorly understood.MethodsCD4+ T cells isolated from peripheral blood of healthy human donors were stimulated using anti‐CD3/anti‐CD28‐coated beads. Proteomic profiling of microvesicles was performed using linear discriminant analysis (LDA) from activated T cells (MV.Act) and nonactivated T cells (MV.NAct). In addition, data processing analysis was performed using MaxQUANT workflow. Differentially expressed proteins found in MV.Act or MV.NAct samples with identification frequency = 100%, which were selected by both LDA (p < .01) and MaxQUANT (p < .01) workflows, were defined as “high‐confidence” differentially expressed proteins. Functional effects of MV.Act on human primary microvascular endothelial cells were analysed.ResultsT cells released large amounts of microvesicles upon stimulation. Proteomic profiling of microvesicles using LDA identified 2279 proteins (n = 2110 and n = 851 proteins in MV.Act and MV.NAct, respectively). Protein–protein interaction network models reconstructed from both differentially expressed proteins (n = 594; LDA p ≤ .01) and “high‐confidence” differentially expressed proteins (n = 98; p ≤ .01) revealed that MV.Act were enriched with proteins related to immune responses, protein translation, cytoskeleton organisation and TNFα‐induced apoptosis. For instance, MV.Act were highly enriched with IFN‐γ, a key proinflammatory pathway related to effector CD4+ T cells. Endothelial cell incubation with MV.Act induced superoxide generation, apoptosis, endothelial wound healing impairment and endothelial monolayer barrier disruption.ConclusionsT cell receptor‐mediated activation of CD4+ T cells stimulates the release of microvesicles enriched with proteins involved in immune responses, inflammation and apoptosis. T cell‐derived microvesicles alter microvascular endothelial function and barrier permeability, potentially promoting tissue inflammation.
Introgression of domesticated salmon changes life history and phenology of a wild salmon population
Authors: Besnier Francois , Ayllon Fernando , Skaala Øystein , Solberg Monica Favnebøe , Fjeldheim Per Tommy , Anderson Kaja , Knutar Sofie , Glover Kevin Alan 
Published: March 2022

AbstractThe release of domesticated conspecifics into the natural environment, whether deliberate or accidental, has the potential to alter the genetic integrity and evolutionary trajectory of wild populations. This widespread challenge is of particular concern for wild Atlantic salmon. By investigating phenotypic differences between the offspring of domesticated, hybrid, and wild Atlantic salmon released into the natural environment, earlier studies have documented the short‐term consequences of introgression from domesticated fish into wild salmon populations. However, few studies have investigated the joined product of introgression and natural selection after several generations. Here, we investigated the phenotypic response of an Atlantic salmon population that has been subjected to an average of 24% genetic admixture by domesticated conspecifics escaping from fish farms over three decades (approximately 6–7 generations). Individual levels of admixture were positively correlated with increased size at the smolt and adult stages for both sexes, a decrease in the age of male smolts, and a decrease in the age at maturity for males. These life history changes are presumably the consequence of the well‐documented directional selection for increased growth in domesticated salmon and are likely maladaptive. However, the most novel result of this study is that admixture was positively linked with delayed date of return to the river, with highly admixed fish arriving up to 26 days later than nonadmixed fish. Potentially, this phenological change provides admixed individuals with a survival advantage in the later phase of the life cycle as it reduces their period of exposure to selection through rod and line angling. We, therefore, conclude that while gene flow from domesticated conspecifics changes life history and phenological traits of wild Atlantic salmon populations, most of which are likely to be maladaptive, when pressured by additional anthropogenic challenges, some changes may confer a fitness advantage for a short part of the life cycle.
Sphalerite and Zinc Metal Nugget Reference Materials for In Situ Zinc Isotope Ratio Determination Using fsLA‐MC‐ICP‐MS
Authors: Bao Zhian , Nie Xiaojuan , Chen Kaiyun , Zong Chunlei , Lv Nan , Yuan Honglin 
Published: March 2022

This study examined the micro‐homogeneity of zinc isotope composition of the NIST SRM 683 and NBS 123 reference materials using femtosecond laser ablation multi‐collector inductively coupled plasma‐mass spectrometry (fsLA‐MC‐ICP‐MS). NIST SRM 683 and NBS 123 are homogeneous in Zn isotope composition based on numerous measurements performed on twenty chips and four mounts of sphalerite using solution nebulisation (SN)‐MC‐ICP‐MS and fsLA‐MC‐ICP‐MS. The mean δ66ZnJMC‐Lyon values of NIST SRM 683 and NBS 123 determined by SN‐MC‐ICP‐MS were 0.11 ± 0.02‰ (2 standard deviation (2s), n = 100) and 0.16 ± 0.02‰ (2s, n = 62), respectively. The mean δ66ZnJMC‐Lyon values determined by fsLA‐MC‐ICP‐MS analyses for NIST SRM 683 and NBS 123 were 0.12 ± 0.05‰ (2s, n = 200) and 0.16 ± 0.05‰ (2s, n = 212), consistent with the bulk isotope compositions within uncertainty. The in situ measurement precision for NIST SRM 683 and NBS 123 was better than 0.06‰ (2s), suggesting NIST SRM 683 and NBS 123 are suitable to serve as microanalytical reference materials for Zn isotope measurement. Zinc isotopic compositions of Zn‐rich materials were also determined using fsLA‐MC‐ICP‐MS under wet/dry plasma conditions. Their δ66ZnJMC‐Lyon values were in agreement with those obtained by SN‐MC‐ICP‐MS analysis, suggesting that fsLA‐MC‐ICP‐MS is suitable to measure Zn isotopic ratios in Zn‐rich materials. Thus, this method could potentially analyse spatially resolved Zn isotope compositions at the mineral or even sub‐mineral scale, such as to address the process of ore formation or Zn redistribution in near‐surface environments.
BAFF rs9514828 gene polymorphism and the risk of the development of inhibitors in children with severe haemophilia A
Authors: Hodeib Hossam , El Amrousy Doaa , Youssef Amira , Elaskary Eman , Fouda Mohamed H. 
Published: March 2022

AbstractIntroductionHaemophilia A (HA) is an x‐linked recessive disease due to deficiency of coagulation factor VIII (FVIII). The development of neutralizing antibodies (inhibitors) against infused FVIII is a major concern. B cell activating factor (BAFF) has been implicated in several autoimmune diseases.AimWe aimed to evaluate the possible association of BAFF rs9514828 gene polymorphism and the risk of the development of FVIII inhibitor in children with severe HA.MethodsThis cohort study was carried out on 100 newly diagnosed boys with severe HA who were never treated before with FVIII concentrate. Assessment of serum levels of BAFF and BAFF rs9514828 genotyping at first diagnosis was performed and the patients were followed up for the completion of a total of 50 exposure days or the development of inhibitors whichever occurred first. The patients were divided as positive or negative according to the presence or absence of inhibitors.ResultsThe risk allele for BAFF rs9514828 (T) was significantly more frequent in the inhibitor positive patients than the inhibitor negative patients (P = .003). In addition, CT+TT genotypes were associated with increased risk of FVIII inhibitor development. Receiver operating characteristics (ROC) analysis showed that BAFF levels could predict the development of FVIII inhibitors at a cut‐off value of ≥ .92 with a sensitivity of 85.9% and a specificity of 80.2%.ConclusionBAFF rs9514828 gene polymorphism could be independent risk factor and elevated BAFF levels might be useful prognostic marker for the development of FVIII inhibitor in newly diagnosed children with severe HA.
Globalizing higher education through internationalization and multiculturalism: The case of Indonesia
Authors: Sibawaihi Sibawaihi , Fernandes Venesser 
Published: March 2022

AbstractAs part of the efforts to globalize higher education in Indonesia, internationalization and multiculturalism are two globalization behaviors that have been promoted across higher education institutions. This study investigated both these behaviors through a qualitative case study analysis of four state universities in the country. The authors found that firstly, the autonomy of state higher education institutions played a significant role for the implementation of internationalization programs which is related not only to the flexibility in designing international programs, opening study programs, or recruiting foreign lecturers, but also to the budget amount allocations by the government. Secondly, in developing multiculturalism serious considerations on the cultural stance of the institution and the unique ideology of that institution needs to be undertaken and integrated with the national ideology. Thirdly, the role of the government in making policies and encouraging state higher education institutions to be more autonomous is essential to advance higher education in internationalization and multiculturalism.
Restorative justice and the culture of control
Authors: Johnstone Gerry 
Published: March 2022

AbstractA profound change has occurred, during the last half century, in patterns and strategies for handling crime in modern societies. During the same period, the campaign for restorative justice has increasingly influenced penal policy and practice. In stories about correctional change, these developments are often linked by suggestions that the success of the campaign for restorative justice puts in question notions that we are experiencing relentless penal regression. This article argues for a different narrative, in which the rise of restorative justice is located within a broader disenchantment with large‐scale, institutionalised ways of handling crime.
Challenging co‐optive criminalisation: Feminist‐centred decarceration strategies for interpersonal and sexualised violence
Authors: Pali Brunilda , Canning Victoria 
Published: March 2022

AbstractFeminism and prison abolitionism are not theoretically or politically homogenous, and yet in their mainstream versions they are often situated at polar ends of the debate on how to respond to domestic and sexualised violence. The disproportionately gendered nature of sexualised and interpersonal violence has largely centralised such abuses in feminist movements. However, histories of abolitionism – particularly in continental Europe – have largely failed to address the severity of this violence and its impacts. In this article, we highlight the implications of so‐called ‘carceral’ feminism on ending sexualised and interpersonal violence, while addressing key – and reasonable – critiques of abolitionism. Our central argument is that criminal justice has failed to significantly reduce and/or end sexualised or interpersonal violence. As such, we explore feminist‐centred, restorative, and transformative alternatives, not only to prison, but to societies that continue to embed systematic levels of sexualised and interpersonal violence.