bluuebunny/crossref_metadata_2025_split huggingface dataset:
The genetic diversity and variation in crude protein content of wheat (Triticum aestivum L.) promising cultivars for breeding in Albania
Authors: Dervishi Aida , Rumano Merita , Ruzi Panajota , Çakalli Adriatik 
Published: November 2022

The genetic diversity and variation in crude protein content among eleven wheat genotypes, comprising three elite local genotypes and eight wheat genotypes of foreign origin were investigated in the present study. Variability was evidenced in grain protein content estimated by biuret test, it ranged from 9.5 to 13.9% with mean of 11.58%. Comparative analysis between local and introduced wheat genotypes revealed that the local genotypes had lower protein content than those of foreign origin. Fourteen polymorphic RAPD markers were used to assess genetic diversity among selected wheat varieties. The mean similarity among wheat genotypes was 67%. Genetic similarity among local wheat varieties was higher (83%) than among those of foreign origin (66%). The wheat genotypes were grouped into two main clusters on UPGMA dendrogram constructed based on Dice similarity coefficients. A clear clustering of genotypes according to the origin wasobserved. This clustering was also supported by principal coordinate analysis (PCoA) results. There was no observed clustering based on the protein content. The data revealed that local wheat genetic had narrow genetic diversity, however the wheat genotypes of foreign origin constitute a promising material to be employed in breeding programs aiming the increase of wheat protein content and genetic diversity.
Extending Environments to Measure Self-reflection in Reinforcement Learning
Authors: Alexander Samuel Allen , Castaneda Michael , Compher Kevin , Martinez Oscar 
Published: November 2022

Abstract
We consider an extended notion of reinforcement learning in which the environment can simulate the agent and base its outputs on the agent’s hypothetical behavior. Since good performance usually requires paying attention to whatever things the environment’s outputs are based on, we argue that for an agent to achieve on-average good performance across many such extended environments, it is necessary for the agent to self-reflect. Thus weighted-average performance over the space of all suitably well-behaved extended environments could be considered a way of measuring how self-reflective an agent is. We give examples of extended environments and introduce a simple transformation which experimentally seems to increase some standard RL agents’ performance in a certain type of extended environment.
Parricídio e psicose
Authors: Valença Alexandre Martins , Telles Lisieux Elaine de Borba , Silva Antônio Geraldo da , Alexandre Milena Ferreira de França 
Published: November 2022

O artigo objetiva realizar uma revisão sobre o tema de parricídio e doença mental, e descrever o caso de um homem com transtorno psicótico que assassinou o genitor. É discutida a imputabilidade penal e a importância do tratamento psiquiátrico para a prevenção desses casos.
USING DUOLINGO APPS TO IMPROVE ENGLISH READING COMPREHENSION OF ENGINEERING STUDENTS IN UNIVERSITAS BORNEO TARAKAN
Authors: Ajisoko Pangkuh 
Published: November 2022

Learning English is matter of learning language components and language skills. Reading is the most difficult learning that plays important role in mastering English Language. Learning reading is quite challenging. It needs various techniques and applications. The transformation of English language learning is mostly affected by technological advances. The development of English Language Teaching (ELT) resources, Duolingo participates to transform method of English language learning on smartphone. The aim of this study is to find out the impact of Duolingo in ELT as extensive learning. Pre-experimental design with pre-test and post-test was used in this research. The researcher involved 15 students as sample with 2 months practicing duolingo apps with 20 xp on each day intensity of practice. The researcher used reading tests as pre-test and post-test and questionnaire to see students’ perception. According to the results, there was massive improvement on students score. Students also felt that Duolingo is useful apps to use everyday to learn English.
Uma análise diacrônica das formas pronominais contigo e com você em cartas pessoais
Authors: Silva Thaissa Frota Teixeira de Araujo 
Published: November 2022

O presente trabalho apresenta uma análise das variantes oblíquas de 2SG com destaque para a alternância contigo ~ com você em cartas pessoais fluminenses datadas entre fins do século XIX e decorrer do século XX. Levamos em conta os princípios da sociolinguística histórica (HERNÀNDEX-CAMPOY; CONDE SILVESTRE, 2012) para análise de um corpus diacrônico. Os resultados evidenciam que a alternância contigo ~ com você se coloca de maneira mais equilibrada que a oposição prep.+ti ~ prep.+você. Além disso, a forma contigo é predominante entre missivas trocadas entre familiares e há indícios de que seja, no terceiro período de tempo analisado, mais resistente a entradas das formas de você do que as demais estratégias oblíquas do paradigma de tu.
Організація дистанційного навчання учнів на уроках біології
Authors: Нікітченко Лілія , Баюрко Наталія 
Published: November 2022

The article deals with the organization of distance education in biology classes, which is today the only way for students to obtain the necessary knowledge. The organization of the educational process by means of distance education is based on the use of both the best traditional teaching methods and new information and telecommunication technologies, as well as on the principles of independent learning of students. Online learning at school offers students a wide selection of educational videos, created both in the format of traditional lessons and in the form of small popular science films. Such tools significantly expand the possibilities of teaching biology, offer a fundamentally new approach to acquiring knowledge in general. To date, distance learning has become an integral part of the learning process in institutions of general secondary education. Of course, distance learning cannot completely replace the process of traditional learning in school classes, but distance technologies are quite capable of playing the role of convenient and effective tools for teaching biology at school.
The article describes the services that helped diversify biology lessons during distance learning. The model of students' competence formation in biology lessons using distance learning technologies is also described. When building the model, the most essential properties and interrelationships of the learning process of students in biology classes in institutions of general secondary education with the help of distance learning technologies were taken into account. We constructed a model for training schoolchildren using distance learning technologies based on the following components: purpose, principles, content blocks, practical blocks, components of readiness and their corresponding criterion indicators, levels of students' competence development, and the result. the proposed model is based on the idea of a comprehensive approach to the process of teaching students in biology classes in remote mode and is implemented through a rational combination of the existing pedagogical experience of the teacher with innovative and information technologies, which are aimed at mastering the competencies of students in the process of educational activities in institutions of general secondary education.
EFEITOS DOS CONTROLES INFORMAIS E DA IDENTIFICAÇÃO ORGANIZACIONAL NO COMPROMETIMENTO AFETIVO
Authors: Monteiro Januário José , Lunkes Rogério João 
Published: November 2022

O objetivo do estudo é analisar os efeitos dos controles informais e da identificação organizacional no comprometimento afetivo em empresa familiar. Uma Survey foi realizada com 102 funcionários, e as hipóteses foram analisadas por meio de modelagem de equações estruturais e Fuzzy set qualitative comparative analysis. Os resultados mostram que os controles informais influenciam positivamente na identificação organizacional e no comprometimento afetivo.Verificou-se ainda a mediação parcial da identificação organizacional na relação entre os controles informais e o comprometimento afetivo. A abordagem assimétrica aponta que os controles informais e a identificação organizacional são elementos centrais na previsão de alto comprometimento afetivo.
GASTOS E EFICIÊNCIA DAS POLÍTICAS PÚBLICAS EM EDUCAÇÃO NA MICRORREGIÃO DE PARANAGUÁ
Authors: Bonatto Hamilton , Da Silva Christian Luiz , Da Silva Nogueira Sónia Paula , Baptista Ribeiro Nuno Adriano , Lima Nilton Cesar 
Published: November 2022

O objetivo da pesquisa é avaliar a evolução dos gastos públicos e analisar a eficiência das políticas públicas na função educação nos municípios da microrregião de Paranaguá-PR. Foi realizada uma revisão bibliográfica e instrumentalizados os dados oficiais financeiros dos municípios através do Data Envelopment Analysis – DEA (Análise Envoltória de Dados). As análises foram realizadas pelos métodos de Retorno Constante de Escala – CCR e Retornos Variáveis de Escala – BCC, ambos orientados para os outputs, no período compreendido entre 2008 e 2016, em intervalo de quatro anos. Como resultado, observou-se que a qualidade da função pública de educação é diretamente proporcional ao investimento nessas políticas públicas municipais e, quanto à eficiência, observa-se que tanto pelo método CCR como pelo BCC, há considerável homogeneidade entre os municípios.
Forms of special knowledge used during the investigation of secret theft of someone else's property
Authors: Haidar O. V. 
Published: November 2022

The concept of special knowledge forms used during pre-trial investigation is considered. The views of scientists regarding the classification of special knowledge forms used during the investigation of criminal proceedings are analyzed. The opinion of the majority of scientists regarding the division of forms of special knowledge into procedural and non-procedural ones is highlighted. In addition, besides procedural and non-procedural forms of special knowledge, the statement on the selection of such a form as mixed, which combines the features of the two forms indicated above, is considered. Another division of special knowledge by forms is also analyzed. Each form of special knowledge is explored in more detail.
Statistical studies of scientists regarding the use of forms of special knowledge in practical activities are presented. Scientific views on conducting forensic examinations in criminal proceedings are analyzed. Peculiarities of appointment of examinations are considered. Aspects of the expediency of using advisory and reference information during the investigation of criminal offenses, in particular theft, are highlighted. The positive consequences of the involvement of specialists in conducting investigative (research) actions as a form of special knowledge are clarified.
The main goals of special knowledge used during the investigation of secret theft of someone else's property are determined. Forms of special knowledge, which are used during the inspection of the scene at the beginning of the pre-trial investigation, are revealed. Judicial practice in criminal cases based on the fact of theft regarding the use of forms of special knowledge during pre-trial investigation is selectively considered. The forms of special knowledge used during the investigation of the secret theft of someone else’s property are analyzed.
The need to involve specialists in inspecting the scene during the investigation of thefts is revealed. It is emphasized that it is mandatory to appoint a commodity expert when investigating the secret theft of someone else’s property. The expediency of involving experts and specialists in the investigative (search) actions carried out during the investigation of the above offenses is analyzed. Attention is paid to consultations and references that can carry important information and influence the receipt of substantive evidence.
A combined anterior cruciate ligament/Meniscal injury alters the patellofemoral joint kinematics of anterior cruciate ligament-deficient knees during a single-leg lunge exercise: A cross-sectional study
Authors: Huang Wenhan , Zeng Xiaolong , Li Mengyuan , Chen Haobin , Lai Huahao , Yan Yuan , Zhong Hua , Zhang Yu 
Published: November 2022

Anterior cruciate ligament deficiency (ACLD) is often accompanied by concomitant meniscal tears. The study aimed to assess the kinematic alterations of patellofemoral joint (PFJ) in anterior cruciate ligament deficiency knees with or without meniscal tears during a single-leg lunge. Sixty unilateral anterior cruciate ligament deficiency patients were recruited for the study, including 15 isolated anterior cruciate ligament deficiency patients (group 1), 15 anterior cruciate ligament deficiency patients with medial meniscal tears (group 2), 15 patients with lateral meniscal tears (group 3) and 15 patients with combined medial/lateral meniscal tears (group 4). The patellofemoral joint kinematics were determined by a single fluoroscopic image system. Patellofemoral joint kinematics of contralateral anterior cruciate ligament-intact (ACLI) and anterior cruciate ligament deficiency knees were compared. With or without meniscal tears, anterior cruciate ligament deficiency knees had significantly smaller patellar flexion than the anterior cruciate ligament-intact knees (∼5°–10°; p &lt; 0.05). anterior cruciate ligament deficiency knees had more patellar lateral tilting by approximately 1°–2° than the anterior cruciate ligament-intact knees (p &lt; 0.05) in groups 2, 3, and 4. anterior cruciate ligament deficiency groups with medial meniscal deficiencies showed consistent increased lateral patellar translations (2–4 mm) compared to the anterior cruciate ligament-intact group during a single-leg lunge. The results indicate that meniscal tears alter anterior cruciate ligament deficiency patients’ patellofemoral joint kinematics and the types of the meniscal injuries also affect the patellofemoral joint kinematics. Considering the varying effects of meniscal tears on the patellofemoral joint kinematics, specific treatments for anterior cruciate ligament deficiency patients with meniscal tears should be proposed in some closed kinetic chain (CKC) exercise programs, such as single-leg lunge.
Temperature- and pH-responsive injectable chitosan hydrogels loaded with doxorubicin and curcumin as long-lasting release platforms for the treatment of solid tumors
Authors: Li Na , Lin Jianjun , Liu Chunping , Zhang Qian , Li Riwang , Wang Chuang , Zhao Chaochao , Lu Lu , Zhou Changren , Tian Jinhuan , Ding Shan 
Published: November 2022

The efficacy of treating solid tumors with chemotherapy is primarily hindered by dose-limiting toxicity due to off-target effects and the heterogeneous drug distribution caused by the dense extracellular matrix. The enhanced permeability and retention (EPR) effect within tumors restricts the circulation and diffusion of drugs. To overcome these obstacles, hydrogels formed in situ at the tumor site have been proposed to promote drug accumulation, retention, and long-lasting release. We developed a thiolated chitosan (CSSH) hydrogel with a gelation point of 37°C. Due to the pH-sensitive characteristics of disulfides, the prepared hydrogel facilitated drug release in the acidic tumor environment. A drug release system composed of hydrophilic doxorubicin (Dox) and hydrophobic liposome-encapsulated curcumin (Cur–Lip) was designed to enhance the long-lasting therapeutic impacts and reduce adverse side effects. These composite gels possess a suitable gelation time of approximately 8–12 min under physiological conditions. The cumulative release ratio was higher at pH = 5.5 than at pH = 7.4 over the first 24 h, during which approximately 10% of the Dox was released, and Cur was released slowly over the following 24–120 h. Cell assays indicated that the Cur–Lip/Dox/CSSH gels effectively inhibited the growth of cancer cells. These in situ-formed Cur–Lip/Dox gels with long-term drug release capabilities have potential applications for tumor suppression and tissue regeneration after surgical tumor resection.
Comparative genomics analysis of the multidrug-resistant Aeromonas hydrophila MX16A providing insights into antibiotic resistance genes
Authors: Guo Yuxin , Zeng Chenxi , Ma Chenjie , Cai Hongjiao , Jiang Xinglong , Zhai Shaowei , Xu Xiaojin , Lin Mao 
Published: November 2022

In this paper, the whole genome of the multidrug-resistant Aeromonas hydrophila MX16A was comprehensively analyzed and compared after sequencing by PacBio RS II. To shed light on the drug resistance mechanism of A. hydrophila MX16A, a Kirby-Bauer disk diffusion method was used to assess the phenotypic drug susceptibility. Importantly, resistance against β-lactam, sulfonamides, rifamycins, macrolides, tetracyclines and chloramphenicols was largely consistent with the prediction analysis results of drug resistance genes in the CARD database. The varied types of resistance genes identified from A. hydrophila MX16A revealed multiple resistance mechanisms, including enzyme inactivation, gene mutation and active effusion. The publicly available complete genomes of 35 Aeromonas hydrophila strains on NCBI, including MX16A, were downloaded for genomic comparison and analysis. The analysis of 33 genomes with ANI greater than 95% showed that the pan-genome consisted of 9556 genes, and the core genes converged to 3485 genes. In summary, the obtained results showed that A. hydrophila exhibited a great genomic diversity as well as diverse metabolic function and it is believed that frequent exchanges between strains lead to the horizontal transfer of drug resistance genes.
Preoperative left atrial volume index may be associated with postoperative atrial fibrillation in non-cardiac surgery
Authors: Oh Ah Ran , Lee Sung Ho , Park Jungchan , Lee Jong-Hwan , Cha Dahye , Yang Kwangmo , Choi Jin-Ho , Ahn Joonghyun , Sung Ji Dong , Choi Bogeum , Lee Seung-Hwa 
Published: November 2022

BackgroundPostoperative atrial fibrillation (POAF) is related to mortality after non-cardiac surgery. Left atrial volume index (LAVI) is known to be associated with prognosis and development of atrial fibrillation, but it has not been fully investigated in patients undergoing non-cardiac surgery.Materials and methodsA total of 203,787 consecutive adult patients underwent non-cardiac surgery at our institution between January 2011 and June 2019. After identifying those with available LAVI estimated during preoperative echocardiography, we divided them into those with LAVI higher and lower than 34 mL/m2. The primary outcome was incidence of POAF.ResultsA total of 83,097 patients were enrolled in this study. The study patients were divided into the low (57,838 [69.6%]) and high (25,259 [30.4%]) LAVI groups. After an adjustment, higher LAVI was associated with increased incidence of POAF (5.1% vs. 8.1%; odds ratio [OR], 1.33; 95% confidence interval [CI], 1.25–1.41; p &lt; 0.001). In 24,549 pairs of propensity-score-matched population, the result was similar (6.2% vs. 7.9%; OR, 1.30; 95% CI, 1.21–1.39; p &lt; 0.001). The estimated threshold of LAVI associated with POAF was 36.4 mL/m2 with an area under the curve of 0.571. Subgroup analysis in non-thoracic and thoracic surgery showed that the association between preoperative LAVI and POAF significantly interacted with diastolic dysfunction (p for interaction &lt; 0.001), and the observed association was valid in patients without diastolic dysfunction.ConclusionPreoperative LAVI was shown to be associated with POAF in non-cardiac surgery. Our result needs verification in further studies.
Drug-coated balloon in the treatment of coronary left main true bifurcation lesion: A patient-level propensity-matched analysis
Authors: Pan Liang , Lu Wenjie , Han Zhanying , Pan Sancong , Wang Xi , Shan Yingguang , Peng Meng , Qin Xiaofei , Sun Guoju , Zhang Peisheng , Dong Jianzeng , Qiu Chunguang 
Published: November 2022

AimsAn increasing body of evidence suggests that drug-coated balloon (DCB) angioplasty represents a valuable option for revascularization in selected patients with coronary bifurcation disease. However, there remains a paucity of real-world observational evidence on the efficacy of DCB in left main (LM) true bifurcation lesion. We compared clinical and angiographic outcomes of hybrid [DCB + drug-eluting stent (DES)] versus DES-only strategy (provisional stenting or two-stent strategies) in de novo LM true bifurcated lesions.MethodsThe primary endpoint was the 2-year composite rate of target lesion failure (TLF): cardiac death, target vessel myocardial infarction (TVMI), or clinically driven target lesion revascularization (CD-TLR). A routine 1-year angiographic follow-up was scheduled. Propensity-score matching was utilized to assemble a cohort of patients with similar baseline characteristics.ResultsAmong 1077 eligible patients, 199 who received DCB treatment and 398 who were assigned to DES therapy had similar propensity scores and were included in the analysis. TLF within 2 years occurred in 13 patients (7.56%) assigned to DCB group, and 52 patients (14.36%) assigned to DES group (odds ratio: 0.487; 95% confidence interval: 0.258–0.922; P = 0.025; Log-rank P = 0.024). Compared with the DES group, the DCB group resulted in a lower rate of CD-TLR (2.91% vs. 9.42%; P = 0.007). Cardiac death, TVMI, all-cause mortality, and stent thrombosis were comparable between both groups. Patients treated with DES-only were associated with a higher late lumen loss (0.42 ± 0.62 mm vs. 0.13 ± 0.42 mm, P &lt; 0.001) compared with the DCB group at 1 year. In sensitivity analysis, the DCB group also presented a lower incidence of TLF, CD-TLR and stent thrombosis both compared to the two-stent strategy and compared to provisional stenting (Ps &lt; 0.05).ConclusionThe 2-year results of PCI utilizing DCB for LM true bifurcation lesions are superior to employing DES alone in terms of safety and effectiveness.