bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion and prominent epidermal involvement: A case report
Authors: Vest Blake E. , Harview Christina L. , Liu Vincent , Swick Brian L. , Berrebi Kristen G. , Olivares Shantel , Stone Mary S. , Sargen Michael R. , Gerami Pedram 
Published: June 2022

AbstractCutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMCT) is a recently described entity with only 13 cases reported in the literature. Histopathologically, the neoplasm consists of atypical epithelioid to spindled cells that form a well‐circumscribed nodule usually confined to the dermis and subcutis with cytological features including large vesicular nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. Immunohistochemistry shows variable expressivity of melanocytic markers. Currently, there are limited data regarding long‐term outcomes of this newly described entity. Most cases have done well, but there is one case reported with an adverse event. Hence, further studies are needed to accurately classify this tumor. Definitive diagnosis is made by laboratory evidence of CMCT. Herein, we report the first case of CMCT with epidermal involvement in the youngest patient known to be affected to date.
Droplet nuclei are generated during colonoscopy and are decreased by the use of carbon dioxide and water immersion technique
Authors: Chan Shannon Melissa , Ma Tsz Wah , Chu Simon , Fei Hon Sok , Futaba Kaori , Yip Hon Chi , Teoh Anthony Yuen Bun , Wong Martin Chi‐Sang , Ng Simon Siu Man , Ng Enders Kwok Wai , Chiu Philip Wai Yan 
Published: June 2022

ObjectivesThe COVID‐19 pandemic has raised concerns on whether colonoscopies (CS) carry a transmission risk. The aim was to determine whether CS are aerosol‐generating procedures.MethodsThis was a prospective observational trial including all patients undergoing CS at the Prince of Wales Hospital from 1 June to 31 July 2020. Three particle counters were placed 10 cm from each patient’s anus and near the mouth of endoscopists and nurses. The particle counter recorded the number of particles of size 0.3, 0.5, 0.7, 1, 5, and 10 μm. Patient demographics, seniority of endoscopists, use of CO2 and water immersion technique, and air particle count (particles/cubic foot, dCF) were recorded. Multilevel modeling was used to test all the hypotheses with a post‐hoc analysis.ResultsA total of 117 patients were recruited. During CS, the level of 5 μm and 10 μm were significantly higher than the baseline period (P = 0.002). Procedures performed by trainees had a higher level of aerosols when compared to specialists (0.3 μm, P < 0.001; 0.5 μm and 0.7 μm, P < 0.001). The use of CO2 and water immersion techniques had significantly lower aerosols generated when compared to air (CO2: 0.3, 0.5, and 0.7 μm: P < 0.001; water immersion: 0.3 μm: P = 0.048; 0.7 μm: P = 0.03). There were no significant increases in any particle sizes during the procedure at the endoscopists' and nurses' mouth. However, 8/117 (6.83%) particle count tracings showed a simultaneous surge of all particle sizes at the patient's anus and endoscopists' and nurses' level during rectal extubation.ConclusionColonoscopy generates droplet nuclei especially during rectal extubation. The use of CO2 and water immersion techniques may mitigate these risks.
The impact of socio‐economic deprivation on access to diabetes technology in adults with type 1 diabetes
Authors: Fallon Ciara , Jones Emma , Oliver Nick , Reddy Monika , Avari Parizad 
Published: June 2022

AbstractBackgroundWith advances in technology, there is an emerging concern that inequalities exist in provision and diabetes outcomes in areas of greater deprivation. We assess the relationship between socio‐economic status and deprivation with access to diabetes technology and their outcomes in adults with type 1 diabetes.MethodsRetrospective, observational analysis of adults attending a tertiary centre, comprising three urban hospitals in the UK. Socio‐economic deprivation was assessed by the English Indices of Deprivation 2019. Data analysis was performed using one‐way ANOVAs and chi‐squared tests.ResultsIn total, 1631 adults aged 44 ± 15 years and 758 (47%) women were included, with 391 (24%) using continuous subcutaneous insulin infusion, 312 (19%) using real‐time continuous glucose monitoring and 558 (34%) using intermittently scanned continuous glucose monitoring. The highest use of diabetes technology was in the least deprived quintile compared to the most deprived quintile (67% vs. 45%, respectively; p < 0.001). HbA1c outcomes were available in 400 participants; no association with deprivation was observed (p = 0.872). Participation in structured education was almost twice as high from the most deprived to the least deprived groups (23% vs. 43%; p < 0.001). Adults with white or mixed ethnicity were more likely to use technology compared to black ethnicity (60% vs. 40%; p < 0.001).ConclusionsAdults living in the most deprived quintile had less technology use. Irrespective of socio‐economic status or ethnicity, glycaemia was positively affected in all groups. It is imperative that health disparities are further addressed.
Giant coronary aneurysms in an infant: Dilemma of MIS‐C
Authors: Drury Alexandra , Wold Kelsey , Healan Steven , Garg Ashish 
Published: June 2022

AbstractCOVID‐19 related multisystem inflammatory syndrome in children (MIS‐C) can present with cardiovascular complications like shock, arrhythmias, pericardial effusion, and coronary artery dilatation. The majority of MIS‐C associated coronary artery abnormalities are dilation or small aneurysms which are transient and resolve in a few weeks. We present here a case of a 3‐month‐old child who was noted to have giant aneurysms of her coronary arteries (LAD and RCA) 26 days after testing positive for COVID‐19. She was treated with IVIG, infliximab, and glucocorticoids along with aspirin, clopidogrel, and enoxaparin. She did not show any signs of coronary ischemia or cardiac dysfunction but continued to have persistent giant coronary artery aneurysms involving the LAD (z‐score ∼35) and RCA (z‐score ∼30). This study emphasizes the importance of early detection and aggressive management of MIS‐C to prevent potentially life‐threatening consequences.
Prevalance and course of tobacco use among individuals receiving coordinated specialty care for first‐episode psychosis
Authors: Rogers R. Tyler , Marino Leslie , Scodes Jennifer , Wall Melanie , Nossel Ilana , Dixon Lisa 
Published: June 2022

AbstractAimTobacco use is decreasing among the general population, but persistent use among individuals in treatment for first‐episode psychosis (FEP) remains a problem. This study aimed to measure the prevalence and course of tobacco use and explore the associations between tobacco use and clinical outcomes in a FEP sample located in New York State (NYS).MethodsParticipants (N = 870) were from the OnTrackNY system of coordinated specialty care clinics in NYS. Participant data were collected at admission to the program and at every 3 months of follow‐up using standardized forms based on reports from clients, client families and chart review. Course of tobacco use was categorized into four groups: no‐use, cessation, persistent and initiation over 1 year of follow‐up.ResultsThe prevalence of tobacco use was 12.8% at baseline and 19.9% at 1‐year follow‐up. Only 3.8% of tobacco users stopped by 1 year follow‐up, and 4.9% initiated use. Urbanicity of clinic location (p < .001); age at admission (p = .044); gender (p = .015); ethnoracial group (p = .007); baseline education/employment status (p = .004); and baseline use of any non‐tobacco substances (p < .001), including alcohol (p < .001) and cannabis (p < .001), were associated with tobacco course. Findings suggest an association between tobacco use and reduced improvement in symptoms.ConclusionDespite a lower prevalence of tobacco use among OnTrack participants than in other comparable samples, tobacco cessation was minimal and more individuals initiated tobacco use than ceased over the course of follow‐up. Efforts to implement tobacco cessation interventions in coordinated specialty care are warranted, since tobacco use is associated with poor health outcomes.
Integrating closed‐loop principles in supply chains in emerging markets: The case of the Russian waste management industry
Authors: Aray Yulia , Veselova Anna , Knatko Dmitri , Levchenko Anna 
Published: June 2022

AbstractsThe integration of closed‐loop (CL) principles in supply chain management plays an important role for business and society. The CL supply chain can serve as a good example of an environment‐friendly and sustainable solution because it assumes waste reduction and further usage in production. Hence, the notion of the CL supply chain is premised on the design, control and operation of a system that creates extra value using the entire product life cycle and capture value recovery from various returns over time. In practice, a successful integration of CL principles depends on many contextual factors. This study aimed to identify the factors that support and discourage CL supply chain innovations in emerging markets. The study employed institutional theory as theoretical background and conducted an in‐depth case analysis of a Russian waste management company to present empirical evidence. The results showed that cooperation with an experienced and legitimate partner can drive the introduction of a CL initiative. Meanwhile, a low level of knowledge and trust might become a serious impediment. Thus, investment in knowledge dissemination and reputation building are crucial in an emerging market.
Long‐term outcome after COVID‐19 infection in multiple sclerosis: A nation‐wide multicenter matched‐control study
Authors: Bsteh Gabriel , Assar Hamid , Gradl Christiane , Heschl Bettina , Hiller Maria‐Sophie , Krajnc Nik , Di Pauli Franziska , Hegen Harald , Traxler Gerhard , Leutmezer Fritz , Wipfler Peter , Zulehner Gudrun , Guger Michael , Enzinger Christian , Berger Thomas ,   for the AUT‐MuSC‐19 investigators
Published: June 2022

AbstractBackground and purposeLong‐term outcome after COVID‐19 in patients with multiple sclerosis (pwMS) has scarcely been studied, and controlled data are lacking. The objective of this study was to compare long‐term outcome after COVID‐19 in pwMS to a matched control group of pwMS without COVID‐19.MethodsWe included pwMS with polymerase chain reaction‐confirmed diagnosis of COVID‐19 and ≥6 months of follow‐up and, as a control group, pwMS matched 1:1 for age, sex, disability level, and disease‐modifying treatment type.ResultsOf 211 pwMS with COVID‐19 (mean age = 42.6 years [SD = 12.2], 69% female, median Expanded Disability Status Scale = 1.5 [range = 0–7.5], 16% anti‐CD20), 90.5% initially had a mild COVID‐19 course. At follow‐up, 70% had recovered completely 3 months (M3) after COVID‐19, 83% after 6 months (M6), and 94% after 12 months (M12). Mild initial COVID‐19 course was the only significant predictor of complete recovery (odds ratio [OR] = 10.5, p < 0.001). The most frequent residual symptoms were fatigue (M3: 18.5%, M6: 13.7%, M12: 7.3%), hyposmia (M3: 13.7%, M6: 5.2%, M12: 1.7%), and dyspnea (M3: 7.1%, M6: 6.6%, M12: 2.8%). Compared to matched controls, fatigue, hyposmia, and dyspnea were significantly more frequent at M3 and still slightly more frequent at M6, whereas there was no difference at M12. pwMS with COVID‐19 had neither a significantly increased risk for relapses (OR = 1.1, p = 0.70) nor disability worsening (OR = 0.96, p = 0.60).ConclusionsLong‐term outcome of COVID‐19 is favorable in a large majority of pwMS, with only a small proportion of patients suffering from persistent symptoms usually resolving after 3–6 months. COVID‐19 is not associated with increased risk of relapse or disability.
Learning to Deal with Disagreement on Ethical Issues
Authors: Sinn Simone 
Published: June 2022

AbstractThis article deals with a new study document, Churches and Moral Discernment: Facilitating Dialogue to Build Koinonia, adopted by the Commission on Faith and Order of the World Council of Churches in 2021. This document addresses basic issues of moral discernment in ecumenical relations and seeks to spell out how churches can deal constructively with disagreement on ethical issues. Such disagreement can lead to tensions that threaten division within churches and can become a burden in ecumenical cooperation between churches. Underlying the specific ethical questions and the complexity of church relations is often the question of the place and self‐understanding of churches in their specific society at a specific time. Thus, it is a question about dealing with the historicity of the public witness of the churches and their reference and relationship to the world. This touches not only on fundamental questions of ethics, but also on the understanding of the church and of ecumenism.
An Ecumenical Theology of Justice for and within Creation
Authors: Culp Kristine A. 
Published: June 2022

AbstractIn 2020, the Commission on Faith and Order of the World Council of Churches (WCC) published Cultivate and Care: An Ecumenical Theology of Justice for and within Creation. This article offers an introduction to Cultivate and Care, highlighting its central themes and aspects, placing it in the context of two related Faith and Order documents, and evaluating its special contributions. The article also looks at the longer trajectory of theological themes that have informed the work of the Faith and Order Commission. Cultivate and Care was developed in conjunction with theological resources for the WCC’s Pilgrimage of Justice and Peace and, in that sense, it is a statement “on the way” to the hope for transformation within the horizon of the ultimate reign of God.
Pilgrimage toward a Common Vision of the Church
Authors: Wondra Ellen K. 
Published: June 2022

AbstractIn 2013, the World Council of Churches (WCC) published its second convergence statement, The Church: Towards a Common Vision (TCTCV), and invited churches, ecumenical councils and groups, and others to respond officially with their assessment of the extent to which convergence had been reached in many areas. After offering an outline of the process in the WCC and its Commission on Faith and Order that led to this statement, this article discusses the process of evaluating the responses to the document and the main issues that were raised in the responses. The article notes the uneven nature of the responses in that no responses were received from Latin America or Africa and very few responses came from Pentecostal, evangelical, charismatic, or independent churches and movements. The article concludes by affirming the need for changes in the methodology of Faith and Order to more readily and clearly hear those churches and peoples who have long and often been marginalized.
Toward an Ecumenical Theology of Companionship
Authors: Enns Fernando 
Published: June 2022

AbstractFollowing the launch of the Pilgrimage of Justice and Peace at the 10th Assembly of the World Council of Churches in Busan, South Korea, in 2013, the Pilgrimage has offered a programmatic perspective for the whole of the global ecumenical fellowship. This article explores the experiences gained in the Pilgrimage in which four common themes emerged: (1) truth and trauma, (2) land and displacement, (3) gender justice, and (4) racial justice. The article goes on to explore theological reflections emerging from these experiences and proposes an ecumenical theology of companionship as a response. The development of such an ecumenical theology of companionship can help to give expression and orientation to the ethos, as well as the responsibility and mission, of those who go on pilgrimage.
Struggling Along in Nigeria: Depression, Treatment, and Morality
Authors: Otto Merel , van Roekel Eva 
Published: June 2022

AbstractIn this article, we analyze the multiple ways of moral beingwithdepression in urban Nigeria, including those of the ethnographer. This approach fits recent theorizing in moral anthropology and mental health that aims at uncovering how mental illness and ethical being come into being in between patients and meaningful others. We argue that the Nigerian experience of depression does not follow the Heideggerian model of moral breakdown and ethical performance but is rather a shared experience of struggling along without the ideal of a full recovery. By proposing a radical reconsideration of existing care models that are largely based on cure and correction, struggling along draws attention to the unfinishedness of depression. This is best described as a heightened everyday awareness that lingers in between reflective and unreflective modes of being that comprise both the physical and metaphysical worlds young Nigerians inhabit and allows for moral being with mental health struggles.
The landscape of genetic alterations of UVB‐induced skin tumors in DNA repair‐deficient mice
Authors: Yoshioka Ai , Nakaoka Hirofumi , Fukumoto Takeshi , Inoue Ituro , Nishigori Chikako , Kunisada Makoto 
Published: June 2022

AbstractNon‐melanoma skin cancer (NMSC) is mainly caused by ultraviolet (UV)‐induced somatic mutations and is characterized by UV signature modifications. Xeroderma pigmentosum group A (Xpa) knockout mice exhibit extreme UV‐induced photo‐skin carcinogenesis, along with a photosensitive phenotype. We performed whole‐exome sequencing (WES) of squamous cell carcinoma (SCC) samples after repetitive ultraviolet B (UVB) exposure to investigate the differences in the landscape of somatic mutations between Xpa knockout and wild‐type mice. Although the tumors that developed in mice harboured UV signature mutations in a similar set of cancer‐related genes, the pattern of transcriptional strand asymmetry was largely different; UV signature mutations in Xpa knockout and wild‐type mice preferentially occurred in transcribed and non‐transcribed strands, respectively, reflecting a deficiency in transcription‐coupled nucleotide excision repair in Xpa knockout mice. Serial time point analyses of WES for a tumor induced by only a single UVB exposure showed pathogenic mutations in Kras, Fat1, and Kmt2c, which may be driver genes for the initiation and promotion of SCC in Xpa knockout mice. Furthermore, the inhibitory effects on tumor production in Xpa knockout mice by the anti‐inflammatory CXCL1 monoclonal antibody affected the pattern of somatic mutations, wherein the transcriptional strand asymmetry was attenuated and the activated signal transduction was shifted from the RAS/RAF/MAPK to the PIK3CA pathway.
Prognostic values of muscle mass assessed by dual‐energy X‐ray absorptiometry and bioelectrical impedance analysis in older patients with heart failure
Authors: Saito Hiroshi , Matsue Yuya , Maeda Daichi , Kasai Takatoshi , Kagiyama Nobuyuki , Endo Yoshiko , Zoda Masato , Mizukami Akira , Yoshioka Kenji , Hashimoto Tomoaki , Ishikawa Kazuya , Minamino Tohru 
Published: June 2022

AimThis study aimed to compare bioelectrical impedance analysis (BIA) and dual‐energy X‐ray absorptiometry (DEXA) in measuring skeletal muscle mass (MM), and its prognostic implications in old patients with heart failure.MethodsWe prospectively evaluated MM measured by both BIA and DEXA in 226 hospitalized elderly (≥65 years) patients with heart failure. The cut‐off values proposed by the Asian Working Group in Sarcopenia were used to define low MM. The prognostic endpoint was all‐cause death.ResultsThe median age of the cohort was 82 years (interquartile range: 75–87), and 51.8% of patients were men. According to the BIA and DEXA, 177 (78.3%) and 120 (53.1%) patients were diagnosed with low MM, respectively, and the two assessment tools showed poor agreement (Cohen's kappa coefficient: 0.294). During the follow‐up, 32 patients (14.2%) died; only low MM defined by DEXA (hazard ratio 2.45, 95% confidence interval 1.05–5.72, P = 0.039), but not BIA (hazard ratio 1.03, 95% confidence interval 0.35–3.06, P = 0.955), was associated with poor prognosis after adjusting for pre‐existing risk factors. Moreover, low MM defined by DEXA (net reclassification improvement: 0.58, P < 0.001), but not BIA (net reclassification improvement: −0.005, P = 0.975), provides incremental prognostic predictability when considered with pre‐existing risk factors and brain natriuretic peptide level at discharge.ConclusionsIn elderly hospitalized patients with heart failure, low MM defined by DEXA and BIA show significant discordance. The MM defined by DEXA, but not BIA, provides additional prognostic value to pre‐existing prognostic models. Geriatr Gerontol Int 2022; 22: 610–615.
Virtual Site Investigation to Evaluate Conceptual Site Model Development at DNAPL‐Impacted Sites
Authors: Mumford Kevin G. , Bryck Sean , Kueper Bernard H. , Mancini Silvia , Kavanaugh Michael , Reynolds David 
Published: June 2022

AbstractThe development of a conceptual site model (CSM) is essential to support decision making for the investigation and remediation of contaminated sites, including sites impacted by dense nonaqueous phase liquids (DNAPLs). Dynamic investigation strategies using high‐resolution site investigation tools can be used to increase the accuracy, and increase the precision (reduce the uncertainty) of a CSM, while balancing life‐cycle costs. However, the evaluation of CSM accuracy is limited by the hydrogeological and biogeochemical complexities inherent in subsurface systems. This study simulated DNAPL migration, dissolution, and reactive transport to create three high‐resolution “virtual sites” composed of 0.4–1 billion parameter values each, which were investigated by teams of leading practitioners. Use of these virtual sites allowed key hydrogeological and biogeochemical parameters to be known by the model developers but not the investigation teams. Comparison of the CSMs developed by these practitioners to the simulated values across multiple metrics (e.g., dissolved concentrations, DNAPL mass, and mass discharge) showed that 92% of those metrics were estimated within a factor of 10 and 63% were within a factor of 3 of the true (simulated) values. Furthermore, estimates of dissolved phase plume footprint were often more accurate than estimates of DNAPL source footprint, and the approaches used for investigation and data analysis were both important for CSM development. Overall, none of the site investigation approaches used to develop the CSMs resulted in the highest accuracy for all metrics, which demonstrates the need to establish best‐practices that draw from multiple approaches and vary depending on investigation objectives.