bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adipose Tissue Mesenchymal Stem Cells Exposed To Oxytocin and Sunitinib are Synergistically Dystrophic
Authors: SOFU Meliz , GOKER BAGCA Bakiye , ERISIK Derya , AVCI Cigir Bıray , UYANIKGIL Yigit 
Published: September 2022

Objective: Mesenchymal stem cells (MSCs) are also promising in immunosuppressed patients after organ and tissue transplantation, in addition to their current wide range of uses and research areas. Sunitinib is a receptor tyrosine kinase with immunosuppressive properties and its cytotoxic activity in different types of cells is known. Our study aimed to elucidate the effect of oxytocin on sunitinib-treated MSCs.
Methods: For this purpose, commercially available rat adipose tissue-derived MSC (ADMSCs) was used. The individual or combinational effect of the active substances on viability was evaluated with WST-1, the effect on apoptosis Annexin V, the effect on oxidative stress markers MDA, CAT, GPX, and SOD ELISA tests.
Results: The IC50 value of sunitinib was determined as 44.57 μM at the 48th hour, and it was determined that oxytocin had no cytotoxic effect in doses up to 100 μM. Treatment of the two agents in combination increased the cytotoxic effect of sunitinib. Oxytocin attenuated the effect of sunitinib on apoptosis and lipid peroxidation.
Conclusion: It is important to investigate the efficacy of these two substances individually and in combination with ADMSCs with further experiments to evaluate the potential use of oxytocin in organ and tissue transplantations.
Adölesan Obezlerde Kan Lipid Profilinin Karotis İntima Media Kalınlığına Etkisi
Authors: TEKİN Suat , GÖZÜ PİRİNÇÇİOĞLU Ayfer , ÜNAL Edip , AKIN Alper , TÜRE Mehmet 
Published: September 2022

Giriş: Çocukluk ve adölesan dönem obezitesi erişkin dönem obezite riskini arttırmaktadır. Bu da aterosklerotik hastalık riski oluşturmaktadır. Karotis intima media kalınlığı (KIMK) ölçümleri erken, preklinik aterosklerozun tespiti için kullanılan yeni belirteçlerdendir. Son çalışmalar, ailesel hiperkolesterolemi ve ciddi obezitesi olan çocuklarda KIMK’nın artmış olduğunu göstermektedir.
Amaç: Bu çalışmamızın amacı obezitesi olan adölesanlarda kan lipid profili ve KIMK arasındaki ilişkinin incelenmesi ve KIMK’nın preklinik ateroskleroz belirteci olarak kullanılabilirliğini değerlendirmektir.
Yöntemler: Çalışmaya yaşları 10-20 arasında değişen ve vücut kitle indeksi (VKİ) yaşa ve cinse göre 95. persentilin üzerinde olan 108 obez hasta çalışma grubu, VKİ 85. persentilin altında olan 101 sağlıklı birey kontrol grubu olarak alındı. Çalışma grubundan en az 12 saatlik açlık sonrası kan glikozu, lipid profili (trigliserit, LDL, VLDL, HDL, total kolesterol) tespiti için kan örneği alındı. Çalışmaya alınan hastaların KIMK değerleri ekokardiyografi cihazı ile ölçüldü.
Bulgular: Kontrol grubu ile kıyaslandığında çalışma grubunda KIMK ve VKİ daha yüksek tespit edildi. Gruplar kan lipid profili yönünden kıyaslandığında trigliserit, LDL ve total kolesterol düzeyleri obez grupta daha yüksek, HDL düzeyi daha düşük tespit edildi. Obez grupta kan lipid profili ile KIMK arasında istatiksel olarak anlamlı bir ilişki saptanmadı.
Sonuç: Çalışmamızda adölesan obezlerde KIMK normal popülasyona göre artmış saptandı. Ancak lipid profili ile KIMK arasında herhangi bir ilişki saptanmadı. Bu nedenle obez adölesanlarda aterosklerozun erken belirlenmesi ve buna yönelik tedbirlerin alınması açısından kan lipid profili normal olsa bile KIMK ölçümünü önermekteyiz.
Ailesel Hiperkolesterolemi Hastalarında Qt Dispersiyonun Değerlendirilmesi
Authors: HATEM Engin , ASLAN Onur 
Published: September 2022

Giriş ve Amaç: Ailesel hiperkolesterolemi (AH), erken kardiyovasküler hastalığa yol açabilen, yüksek düşük yoğunluklu lipoprotein kolesterol (LDL-C) seviyeleri ile ilişkili otozomal dominant geçişli genetik bir hastalıktır. Aterosklerotik etkisinin dışında çeşitli mekanizmalarla kardiyak disfonksiyona neden olabilmektedir. QT dispersiyonu ventriküler repolarizasyonun heterojenitesini yansıtan bir ölçümdür ki çeşitli patolojilerde erken veya önemli bir belirteç olarak araştırılmıştır. Bizim bu çalışmadaki amacımız; ailesel hiperkolesterolemi hastalarında QT dispersiyonunun ve olası klinik etkilerinin araştırılmasıdır.
Yöntemler: Çalışmamıza 30.10.2018-01.11.2019 tarihleri arasında Mersin Şehir Eğitim ve Araştırma Hastanesi kardiyoloji ve endokrinoloji polikliniklerine başvuran 18 yaş üstü ailesel hiperkolesterolemi tanısı alan hastalar dahil edilmiştir. Aterosklerotik risk faktörü ve yerleşik hastalığı olan hastalar çalışma dışında bırakılmıştır. Hastaların EKG’leri dijital ortama aktarılarak iki farklı kardiyoloji uzmanı tarafından değerlendirilmiş ve ortalamaları kaydedilmiştir. Kontrol grubu ile bu değerler kıyaslanmıştır. Sonuçlar SPSS 20.0 paket programına kaydedilerek istatistiksel analiz yapılmıştır.
Bulgular: Çalışmaya toplam 200 hasta dahil edilmiştir. 120(%60)’si kadın, yaş ortalaması 32,28±7,90’dır. Hiperkolesterolemi olan grubun LDL, total kolesterol ve trigliserit değerleri diğer gruba göre anlamlı derecede yüksekti (p
Las metáforas en la deconstrucción del trastorno mental. Análisis del discurso metafórico de Radio Nikosia
Authors: Rojo Pardo María del Carmen , Iñiguez-Rueda Lupicinio 
Published: September 2022

Desde una perspectiva pragmática y del desarrollo teórico de la metáfora como constituyentes de la realidad, las interacciones y las acciones comunicativas, el objetivo de este artículo es identificar el efecto de las estrategias argumentativas en la deconstrucción de la identidad del trastorno mental de personas diagnosticadas con un trastorno mental. El corpus de estudio está formado por materiales de dominio público de Radio Nikosia, y está compuesto por un conjunto de textos extraídos de varias fuentes de producción discursiva en las que se han inferido las metáforas conceptuales observando su correspondencia con el dominio destino. Los resultados han mostrado que el/la hablante organiza estrategias para desenmascarar los procesos de dominación que históricamente han influido en el discurso hegemónico de la psiquiatría. Así mismo, destaca estrategias discursivas en las que las personas participantes se autorepresentan ubicándose en el rol de enfermo/a mental. El estudio de la metáfora conceptual hizo posible mostrar su influencia en los procesos argumentativos y, en concreto, la emergencia de un discurso disidente que lucha contra el estigma social del trastorno mental.
From a pragmatic perspective and from the theoretical development of metaphor as constituents of reality, interactions and communicative actions, the objective of this article is to identify the effect of argumentative strategies in the deconstruction of identity in mental disorders. of people diagnosed with a mental disorder. The study corpus is made up of public domain materials from Radio Ni-kosia, and is made up of a set of texts extracted from various sources of discursive production in which conceptual metaphors have been inferred by observing their correspondence with the target domain. The results have shown that the speaker organizes strategies to unmask the domination processes that have historically influenced the hegemonic discourse of psychiatry. Likewise, it highlights discursive strategies in which the participants represent themselves by placing themselves in the role of mentally ill person. The study of conceptual metaphor made it possible to show its influence on argumentative processes and, specifically, the emergence of a dissident discourse that fights against the social stigma of mental disorders.
Vessel Design Considerations to Limit Motion-Induced Sickness and Interruptions
Authors: Ross Jonathan 
Published: September 2022

By their very essence, modern vessels in general, and many of today’s advanced vessel in particular, forge new frontiers in hull form, propulsion, and materials. The resulting enhancements are enticing, but potential dangers lurk for the human passengers and crew when the new vessels put to sea. Problems can range from bothersome to debilitating, from seasickness to spinal injuries.
Vessel owners, operators, and designers are beginning to address these human element problems. In fact, two compelling trends combined in the first several years of the twenty-first century, pulling the human element from relative obscurity to the forefront of marine vehicle design and operation. The first of these trends, observed by all in the marine industry, was the move toward reduced crew sizes. This trend is driven by the high cost of qualified personnel and the increasing capability and availability of automation, used to replace people with remote sensors and controls. The trend is further advanced through enhanced maintenance practices, which focus on less maintenance at sea by the crew.
Along with the trend toward reduced crew sizes on marine vehicles, recent years have witnessed a dramatic increase in computer modelling capabilities. These capabilities are impressive in the field of design in general, and equally so in the specialized fields of computer-aided modelling and simulation. Simulation enables the prediction of technical parameters such as speed, power, and vessel motions. Simulation also has advanced in the field of human performance, with models addressing task allocation among vehicle operators, as well as learning how people function when stressed by sleep loss, noise, and temperature extremes. Finally, the capability to link the myriad software programs has increased exponentially, enabling designers to link vessel behavior programs and human performance programs.
This paper focuses on how the vessel designer can address two particular categories of the human element: Motion Sickness Incidence and Motion Induced Interruptions. Not considered within the scope of the paper are sopite syndrome, fatigue, sleep loss, injury, and human error.
A Decision Making Process for the Selection of Better Ship Main Dimensions with the Fuel EEDI Requirements
Authors: Calisal Sander , Yurdakul Onur , Kucuksu Gozde , Saydam Ziya 
Published: September 2022

Initial ship design necessitates the evaluation of main ship parameters in order to obtain a feasible design solution satisfying the design objectives. Traditionally, relationships between the main dimensions and design parameters of proven designs provided the basis of a successful and safe solution. This approach restrains the designer from improving the design with respect to possible conflicting design criteria. Pareto frontier technique has widely been utilized in the design of ships, mainly at the advanced design stages for multi-objective optimization problems. As the principal dimensions of a ship, are vital on the performance of a vessel, major improvements in performance may be achieved by selecting “better” principal dimensions. This paper proposes to integrate in the Pareto technique studied earlier by the authors, the EEDI perspective at an early stage in the a decision-making process for the selection of better main dimensions with respect to multiple conflicting criteria. The previous work on the subject showed that rather promising results could be obtained for fishing boats, naval ships and planning hulls. In this case additional requirements are included in the selection using the expected fuel consumption into the owner requirements. The study is now limited to displacement type vessels and well known and tested resistance, seakeeping and propeller algorithms. A Pareto Front has been observed for all cases studied and is seen as a technological barrier for the ship performance with respect to main dimensions.
We believe that the procedure developed reduces future conflicts in the design along the design spiral and satisfying the EEDI fuel reduction requirements. The improved performance of the design with respect to the conflicting design criteria at the initial stage of design also serves as a better basis for further optimization.
Reshaping Digital Twin in Technology Developments for Enhancing Marine Systems Design
Authors: Garcia Agis Jose Jorge , Brett Per Olaf , Erikstad Stein Ove , Gaspar Henrique 
Published: September 2022

The digital twin technology platform has not yet achieved the expected acceptance and wider implementation in the maritime industry. So far, most of the focus of the digital twin application discussions have centred around what to learn from big data in ship operation, and to a lesser extent, has anybody extended this discussion to include the benefits such new technology can contribute to the enhancement of the upstream ship concept and basic design activities, as well as detailed engineering. This paper particularly pays attention to this latter, partly forgotten, application area. There could be many reasons behind such a reluctance to take on new technology and utilize it to its full potential. It is hypothesized and argued by this article that the development has focused on applications that are too complex, too expensive and reflect, to a little extent, real-life needs. Lack of effective data transfer and transaction interphases among relevant stakeholders is another important factor creating these inefficiencies. This paper document how and why such inefficiencies in novel digitization technology adoption and adaptation exist and hamper the progress of achieving noticeable benefits of such implementations and how such development hurdles can be eliminated.
Real-life user cases and several contributions in the professional literature suggest that more effective implementation of digital twin technology requires further discussions and investigations relating to three important aspects: i) a common and accepted definition of what is a digital twin; ii) an agreed-upon scalable and systemic approach to what is the solution space for a digital twin solution and iii) which systemic method to be used for digital twin development. Digital-twin technology must combine effective ship in operation and ship design feedback and feed forwarding, including their inherent people involvement and market behaviour. This article reviews the status of digital twin technology in the maritime domain and proposes a common definition of the digital twin. The latter part of the article proposes a systemic perspective for effective digital twin development and a method for a goal-oriented digital twin development in the novel ship design domain as well for ships in operations. Real-life user-case examples are elaborated upon to support our suggestions for improvement.
The paper summarizes that, in its current form, the success rate of the digital twin technology implementation is so far, limited. Thus, the short- and long-term benefits to be achieved from digital twin applications in relation to vessel operations and their designs are also limited. This paper advises ways for improvement of the present situation.
Naval Wargaming as a Teaching Tool for Warship Design Engineers
Authors: Bradbeer Nick 
Published: September 2022

There is growing interest in the use of wargaming as an educational tool. Typically this has been used to train military personnel or students of defence or international relations, with a focus on the decisions made during a conflict. Wargaming offers several advantages as a pedagogical tool, in particular that it immerses students in a decision-making process in a way which can help develop deeper understanding. UCL has been using wargaming as a teaching tool within its Naval Architecture and Marine Engineering MSc programs for several years. They are used to develop student awareness of the naval domain, to explore the sensitivity of warship capabilities to various design choices, and to informally assess the capability of students’ final capstone designs. This requires wargames which reflect the impact of detailed design decisions like watertight subdivision, damaged stability performance and arrangement of auxiliary supplies and distribution networks. Since no commercially available wargames could be found that offered sufficient granularity in those areas, a family of architecture-focussed wargames was developed in-house between 2015 and 2021. These games were used in teaching seminars, in student study groups and in informal class-wide wargame nights at the end of design exercises. This paper presents a summary of the UCL wargame development program and draws out lessons learned and suggestions for educators considering a similar approach.
Impact of Life-Cycle Considerations on Internal Ship Layout for Damage Stability Protection
Authors: Vassalos Dracos , Paterson Donald , Papanikolaou Apostolos 
Published: September 2022

Historically speaking, the primary driving force behind vessel layout has come in the form of rules and regulations. In such instances, change has occurred slowly, often in a reactive manner in the wake of accidents. The nature of internal layout that is favourable for operation is often in conflict with that for safety and hence objectives pertaining to each generally lie in antithesis. For this reason, the rate of safety progression has often been slowed due to industry resistance on the grounds that their ability to operate a viable business would be impaired. This, in turn, is indicative of a greater problem relating to the efficiency and variety of existing design changes for risk reduction and control. It would appear that there is an urgent need to start seeking alternative and more effective solutions, rather than continued sole reliance on conventional measures such as watertight subdivision. In order to achieve this aim, one must consider the vessel throughout its entire life-cycle (design, operation, emergency response) and understand the requirements within each stage. This would involve consideration of the constraints and conflicting requirements that each stage brings to the decision-making process in relation to the optimal configuration of the internal ship space. Only then, can one hope to provide solutions capable of achieving this aim. The paper presents a framework to address this imbalance with specific applications on design, operation and emergency response on a large passenger ship.
Radiographic Outcomes from Minimally Invasive Bunion Surgery in Australia: A Retrospective Cohort Analysis of 169 Procedures Using the Minimally Invasive Chevron Akin (MICA) Procedure
Authors: Knox Andrew F. , Studdert Nicholas J. , Knox Natasha R. 
Published: September 2022

Abstract
Background: The emergence of minimally invasive techniques in foot and ankle surgery has aimed to reduce iatrogenic tissue insult by utilising the smallest possible incision area to achieve maximum correction of pathological structures. The objective of this study was to assess whether adequate hallux valgus correction can be achieved via the minimally invasive chevron akin (MICA) procedure.
Methods: A retrospective analysis was conducted for a single-surgeon case series of 169 MICA procedures between June 2018 and June 2021 in Australia. Radiographic parameters were evaluated independently by two researchers using 1-2 intermetatarsal angle (1-2 IMA) and hallux valgus angle (HVA) as key measures of procedural outcome.
Results: 95% of participant-operations resulted in normal 1-2 IMA and HVA being obtained post-operatively in a cohort that largely consisted of moderate hallux valgus deformities; 1-2 IMA Reduction: 6.38° ± 3.24 (95% CI 5.89 to 6.87) and HVA Reduction: 20.17° ± 7.69 (95% CI 19.01 to 21.33).
Conclusion: The results of this study help to further strengthen support for the use of minimally invasive bunion surgery as a primary treatment approach in mild to moderate hallux valgus.
Diffractive Entanglements and Readings with/of Data
Authors: Cannon Susan O. 
Published: September 2022

Taking up Haraway’s (1997, 2016) and Barad’s (2007) diffraction I, co-constituted with theory, participant, audio, text, materials, perform an embodied diffractive analysis of the data from one research study. I begin by reckoning with Barad’s objectivity in knowledge production connecting her thinking back through Heisenberg and Bohr. Then, I attend to the specific material arrangements of data production across interconnecting levels. Next, I describe a thought experiment in diffractive methodology. The result is my embodied engagement with and reading across and through the research productions to draw attention to and attend to the differences produced through various material arrangements (https://youtu.be/7JzIeiozzVM).
Internal Control in the Public Sector of Ghana: A Case Study
Authors: Bannerman Jacob , Ebenezer Nii Djan , Obeng Hollack 
Published: September 2022

Internal control is considered to be a key corporate governance mechanism. The purpose of this study is to provide an account of the internal control activities and their challenges from the staff perspective and an insight into the process from the Internal Auditor within the context of the Kumasi Office of Ghana Highways Authority (GHA). The data was obtained from the staff through questionnaire administration and interviewing the Internal Auditor on the process.
The data analysis was descriptive and inferential statistics while the interview responses were analyzed via an interpretative approach. The results revealed that staffs are familiar with the existence of systems for internal control. The purpose of internal controls at GHA was the most critical aspect of its internal control activities. Internal control activities suggest that the tender committee formed to evaluate tender documents and goods bought through contracts are appropriately recorded in books had the majority consensus respectively. The internal auditor suggested that enforcing the formation of an Audit Committee in the region and provision of adequate logistics for internal auditors will improve the internal control activities of GHA. The study recommends that the management of GHA at the regional office must create an environment that can positively influence the control consciousness of entity personnel.
Body Mass Index (BMI) and Cutaneous Lesions among the Elderly Patients in a Tertiary Hospital in Rivers State
Authors: Pepple E. F. , Amadi E. S. , Otike-Odibi B. , Bell-Gam H. I . 
Published: September 2022

Aims: The aim of the study is to highlight that cutaneous lesion can be markers of nutritional status in the elderly.
Study Design: This is a cross-sectional descriptive study.
Place and Duration of Study: This study took place within the wards of University of Port Harcourt Teaching Hospital over a 3 month period.
Methodology: A sample of 126 elderly patients were calculated as the sample size to be assessed for cutaneous lesions, of which 122 were fit enough to have their BMI assessed using standardized protocol of measuring height and weight. The BMI was calculated using the formula -BMI = kg/m2.
Results: Out of the total, 55 of them representing 45.1% had normal BMI, 13 representing 10.7% were underweight, 33 (27%) over weight and 21(17.2%) obese. Underweight elderly patients were more likely than those with normal weight to have xerosis, itching, wrinkles, idiopathic guttate hypomelanosis and ulcers. The elderly with overweight and obesity were more likely to have dermatosis papulosa nigra, signs of post-bleaching syndrome and surgical scars.
Conclusion: Complaints or observance of cutaneous lesions in elderly should be a reason to investigate nutrition and the solution may lie in nutrition based treatment. More research is however needed to further evaluate the association between cutaneous lesions and body mass index.