bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Analysis of Spinal Metastasis Secondary to Lung Cancer after Surgeries: A Unicentric, Large‐Cohort, Retrospective Study
Authors: Zhai Shuheng , Hu Panpan , Liu Xiao , Li Zihe , Wang Ben , Zhou Hua , Liu Zhongjun , Liu Xiaoguang , Li Yan , Wei Feng 
Published: November 2022

PurposeSpinal metastases of lung cancer (SMLC) usually have high degree of malignancy and require surgical treatment. However, there are several controversies about the efficacy of surgery. This study aimed to investigate factors predicting prognosis of SMLC after surgery‐based comprehensive treatment.MethodsA cohort of 112 cases of SMLC who underwent surgical treatment between 2009 and 2020 were retrospectively reviewed and analyzed. The surgical strategies included total en‐bloc spondylectomy, debulking surgery, palliative decompression, and vertebral augmentation procedures. The patients were regularly followed‐up. Survival analysis was performed, as well as analysis of the patients' neurological recovery, pain relief, and improvement of Karnosky performance score (KPS). Cox regression was used to analyze influencing factors of survival time, and Kaplan–Meier method was performed in survival analysis.ResultsThe cohort included 63 males and 49 females, with an average age of 60.6 ± 10.6 years. Median survival time was 16 months. A total of 86.7% of paralysis patients' neurological function recovered and 83.9% of patients with low KPS score (10–40) improved. Surgical method was significantly correlated with improvement of neurological function (p < 0.001) and KPS (p < 0.001). The mean bleeding volume was 502 ml and operative time was 170 min. The survival rates at 3, 6, 12, 24, and 36 months were 92.0%, 80.4%, 63.4%, 63.4%, and 22.6%, respectively. Postoperative Frankel grade (p < 0.001), postoperative KPS score (p = 0.001), and application of molecular targeted drugs (p < 0.001) were significantly correlated with survival time in univariate analysis, while application of molecular targeted drugs was an independent predictor for a longer survival by a multivariate analysis.ConclusionSurgery‐based comprehensive treatment brought a fair outcome, with elongated survival time. Surgery can significantly improve patients' neurological function and physical performance status. Adjuvant targeted therapy is an independent positive factor for patients' survival.
Evaluating the Women's Empowerment and Leadership Initiative: Supporting mentorship, career satisfaction, and well‐being among pediatric anesthesiologists
Authors: Deutsch Nina , Yanofsky Samuel D. , Markowitz Scott D. , Tackett Sean , Berenstain Laura K. , Schwartz Lawrence I. , Flick Randall , Heitmiller Eugenie , Fiadjoe John , Lee Helen H. , Honkanen Anita , Malviya Shobha , Lee Jennifer K. , Schwartz Jamie McElrath 
Published: November 2022

AbstractThe Society for Pediatric Anesthesia launched the Women's Empowerment and Leadership Initiative (WELI) in 2018 to empower highly productive women pediatric anesthesiologists to achieve equity, promotion, and leadership. WELI is focused on six career development domains: promotion and leadership, networking, conceptualization and completion of projects, mentoring, career satisfaction, and sense of well‐being. We sought feedback about whether WELI supported members' career development by surveys emailed in November 2020 (baseline), May 2021 (6 months), and January 2022 (14 months). Program feedback was quantitatively evaluated by the Likert scale questions and qualitatively evaluated by extracting themes from free‐text question responses. The response rates were 60.5% (92 of 152) for the baseline, 51% (82 of 161) for the 6‐month, and 52% (96 of 185) for the 14‐month surveys. Five main themes were identified from the free‐text responses in the 6‐ and 14‐month surveys. Members reported that WELI helped them create meaningful connections through networking, obtain new career opportunities, find tools and projects that supported their career advancement and promotion, build the confidence to try new things beyond their comfort zone, and achieve better work–life integration. Frustration with the inability to connect in‐person during the coronavirus‐19 pandemic was highlighted. Advisors further stated that WELI helped them improve their mentorship skills and gave them insight into early career faculty issues. Relative to the baseline survey, protégés reported greater contributions from WELI at 6 months in helping them clarify their priorities, increase their sense of achievement, and get promoted. These benefits persisted through 14 months. Advisors reported a steady increase in forming new meaningful relationships and finding new collaborators through WELI over time. All the members reported that their self‐rated mentoring abilities improved at 6 months with sustained improvement at 14 months. Thus, programs such as WELI can assist women anesthesiologists and foster gender equity in career development, promotion, and leadership.
Relationship between turnover intention and workplace personal relations among care workers employed by elder care facilities
Authors: Takeda Shinya , Fukuzaki Toshiki 
Published: November 2022

BackgroundThis study focuses on care workers at elder care facilities to examine what factors (including workplace personal relations) influence turnover intention and to what extent. Based on this analysis, the study discusses the content of workplace personal relations problems in qualitative terms.MethodsThe study targeted care workers at elder care facilities. There were 406 participants with no missing data who were analyzed. The survey period ranged from September to November 2021. Questions consisted of basic attributes, turnover intention, problems with workplace personal relations, content of personal relation problems, and psychological distress.ResultsFemale care workers were 2.25 times more likely than male care workers to have turnover intention. Care workers with workplace personal relation problems were 1.97 times more likely than those without these problems to have high turnover intention. Moreover, with regard to psychological distress, the ratio increased to 4.99 times. The following six categories were extracted from the text data on workplace personal relation problems: insufficient communication, bullying, sense of unfair workload, different attitudes to care work, difficulty in guidance for subordinates/new staff, and labelling.ConclusionsGender, workplace personal relation problems, and psychological distress have shown to affect care workers' turnover intentions. To prevent care worker turnover, future studies should focus on the development and impact of strategies to improve workplace personal relations specific to care workers, targeting the six factors identified in this study.
Optimal designs for the development of personalized treatment rules
Authors: Azriel David , Rinott Yosef , Posch Martin 
Published: November 2022

AbstractWe study the design of multi‐armed parallel group clinical trials to estimate personalized treatment rules that identify the best treatment for a given patient with given covariates. Assuming that the outcomes in each treatment arm are given by a homoscedastic linear model, with possibly different variances between treatment arms, and that the trial subjects form a random sample from an unselected overall population, we optimize the (possibly randomized) treatment allocation allowing the allocation rates to depend on the covariates. We find that, for the case of two treatments, the approximately optimal allocation rule does not depend on the value of the covariates but only on the variances of the responses. In contrast, for the case of three treatments or more, the optimal treatment allocation does depend on the values of the covariates as well as the true regression coefficients. The methods are illustrated with a recently published dietary clinical trial.
A randomised controlled trial testing the rebound‐preventing benefit of four days of prednisolone during the induction of oclacitinib therapy in dogs with atopic dermatitis
Authors: Olivry Thierry , Lokianskiene Viktorija , Blanco Alejandro , Mestre Pablo Del , Bergvall Kerstin , Beco Luc 
Published: November 2022

AbstractBackgroundA rebound of pruritus occasionally occurs after oclacitinib dose reduction in dogs with atopic dermatitis (AD).ObjectivesTo determine whether an initial 4‐day course of prednisolone decreases the probability of a pruritus rebound after reducing the frequency of oclacitinib administration.AnimalsForty dogs with mild‐to‐moderate AD lesions and moderate‐to‐severe pruritus.Materials and MethodsDogs were randomised to receive oclacitinib at 0.4–0.6 mg/kg twice daily for 14 days then once daily, alone or with prednisolone at 0.5 mg/kg, orally, twice daily for the first 4 days. Clinicians graded the Canine Atopic Dermatitis Extent and Severity Index (CADESI)4 and 2D‐investigator global assessment (IGA) before and after 28 days; owners assessed the pruritis Visual Analog Scale (PVAS)10 and Owner Global Assessment of Treatment Efficacy (OGATE) on Day (D)0, D4, D14, D21 and D28. We considered a rebound any increase greater than one PVAS10 grade at D21 compared to D14.ResultsOn D21, there were significantly fewer rebounds in the dogs receiving prednisolone (three of 20, 15%) compared to those given oclacitinib alone (nine of 20, 45%; Fisher's test, p = 0.041). Compared to oclacitinib monotherapy, the concurrent administration of prednisolone for the first 4 days led to significantly lower PVAS10 on D4 and D28, CADESI4 and 2D‐IGA on D28, and OGATE on D21 and D28 (Wilcoxon–Mann–Whitney U‐tests). Adverse effects of therapy were minor, intermittent and self‐resolving.Conclusions and Clinical RelevanceThe initial addition of 4 days of prednisolone significantly decreased the probability of a rebound of pruritus 1 week after oclacitinib dose reduction. This short concomitant glucocorticoid administration led to a higher skin lesion improvement and improved perception of treatment efficacy with minimal adverse effects.
Analysis of Pressure Pulsation in Hypercompressor Pipeline
Authors: Geng Maofei , Xiao Jun , Qian Zegang , Liu Shuai , Zhang Chengyan , Wang Le , Yu Xiaoling , Wang Haihong 
Published: November 2022

Abstract
The discharge pressure of hypercompressors in Low Density Polyethylene (LDPE) Plants reaches 350 MPa or higher, its safety and reliability requirements are extremely high. The pipeline vibration is the most important factor that involves the safety of the compressor. The pressure pulsation in the pipeline system is the core cause of the pipeline vibration. For the reciprocating compressors whose discharge pressure is lower than 35MPa, there are relatively complete analysis and measurement methods for pressure pulsation and pipeline vibration in API618. Hypercompressors are often accompanied by big pressure pulsation, far exceed the requirements of API618, but these devices can operate stably for many years, which thanks to detailed acoustic analysis and cyclic stress analysis. In this paper, a LDPE plant pipeline is researched. For security and operability, a non-invasive pressure pulsation measurement method based on the external surface strain of the pipeline is introduced. A detailed acoustic analysis model is established, and based on the pressure pulsation data of more than 60 measuring points arranged in the hypercompressor pipeline, the accuracy of acoustic simulation analysis is verified. The pulsation control components such as buffer tank and orifice are analyzed, the cause of vibration is stripped and analyzed so that targeted control measures can be developed, then some suggestions are given.
Impact of Elevated Loading Rates on the Shape of the Master Curve (ASTM E1921) for a German RPV Steel
Authors: Tlatlik Johannes , Mayer Uwe 
Published: November 2022

Abstract
The Master Curve Methodology (ASTM E1921) experimentally assesses a materials temperature-dependent fracture toughness, predominantly for quasi-static testing conditions. The treatment of elevated loading rates is described by the annex A1 of ASTM E1921 and A14 of ASTM E1820. This paper presents results of the evaluation of a very large and standard-conforming database in order to verify the procedures recommended by the standard.
Testing involved C(T)- and SEN(B)-specimens of the RPV-steel 22NiMoCr3-7 (A508 Grade 2) for loading rates of 100 MPa√m/s ≤ dK/dt ≤ 104 MPa√m/s for the entire ductile to brittle transition region. It was found that the shape and underlying distribution of the Master Curve show stronger shortcomings with increased loading rate. The optimal shape factor p increases with dK/dt, yet the methodology can still show strong shortcomings regarding the underlying distribution. It is argued that the cause for the observations are linked to adiabatic heating and local crack arrest that severely influence macroscopic fracture behavior. It is recommended that fracture mechanics testing at elevated loading rates is performed close to or below T0 in order to minimize the influence of dynamic loading conditions on the assessment.
Validation of the Models in ASME CC N-830-1
Authors: Erickson Marjorie , Kirk Mark , Long Elliot J. 
Published: November 2022

Abstract
The ASME Section XI Working Group on Flaw Evaluation (WGFE) has an ongoing effort intended to implement the KJc Master Curve (MC), as defined in ASTM E1921, into Section XI of the ASME Code. Code Case (CC) N-830 was approved by ASME in 2014 and was the first direct implementation of the KJc MC into the ASME Code. The CC used the 5th percentile lower bound of the Wallin Master Curve as an alternative to the ASME KIc curve to characterize material resistance to fracture in flow evaluations. To take advantage of the best-estimate fracture toughness models developed over the last two decades, CC N-830 was later modified to include a suite of self-consistent fracture toughness models, all linked to T0, that describe material fracture toughness metrics from lower shelf, through transition, to upper shelf behavior (i.e., KJc, KIa, JIc, J0.1, and J-R). Validation efforts described in detail in EPRI MRP 418 Rev. 1 show that the best estimate models contained in CC N-830-1 provide a much more accurate and consistent representation of fracture toughness across all temperatures than do RTNDT/KIc and associated JIc, J-R and KIa methods currently adopted in the Code.
Validation studies in addition to those included in MRP 418-1 were recently performed specifically focusing on materials characterized as having low upper shelf behavior to address concerns raised by Staff from the US Nuclear Regulatory Commission (NRC) regarding the validity of the CC N-830-1 model predictions for materials with upper shelf energy, or USE, &lt; 68 J (50 ft-lbs). While data from such materials has been widely tested (e.g., irradiated Linde-80 weld) and used in the development of the JIc/J-R curve model, little such data was used to demonstrate the validity of the entire CC model (i.e., starting with an appropriate T0 value that is used to predict the J-R curve within the stated CC accuracy). In response to the NRC Staff concern, the Working Group conducted a careful and statistically rigorous analysis of additional low-upper shelf datasets, to provide a more compelling demonstration that no unconservative biases exist within the CC model for such materials. This paper describes the T0 to J-R Curve prediction model validation effort supporting consensus adoption of CC N-830-1 by ASME SC XI.
Utilization of a Sensor Array for the Risk-Aware Navigation in Industrial Plants at Risk of NaTech Accidents
Authors: O’Reilly Gerard J. , Shahnazaryan Davit , Nafeh Al Mouayad Bellah , Ozsarac Volkan , Sarigiannis Denis , Dubini Paolo , Dacarro Filippo , Gotti Alberto , Rosti Annalisa , Silvestri Davide , Brunesi Emanuele , Mascetti Sergio , Ducci Mattia , Carletti Davide , Ciucci Mariano , Marino Alessandra 
Published: November 2022

Abstract
This paper presents an overview of the ROSSINI project, illustrating its general objectives and how it places itself within the overall field of seismic risk-aware navigation systems. In particular, it describes the use of a sensor array for the integrated risk-aware navigation in industrial plants at risk of NaTech accidents. The integration of structural and environmental risks estimated and measured in different ways is presented as part of an integrated risk identification and evaluation (RIE) module. This module will be used along with a series of logic to combine and map the possible risks spatially within an industrial plant’s layout. It is seen how this information can then be used to not only compute the safest path to safety for a worker located within such a plant but also how mobile communications can be used to aid and guide them in different scenarios. All of this stems from the use of a sensor array network in a relatively novel way within this particular context. The paper discusses the progress to date and presents the ongoing results of a pilot case study application of the system to an industrial plant facility in Italy.
Development of a Robust Procedure for the Evaluation of Striation Spacings in Low Cycle Fatigue Specimens Tested in a Simulated PWR Environment
Authors: Howe Benjamin , Mann Jonathan , Que Zaiqing , Huotilainen Caitlin , Scenini Fabio , Burke Grace 
Published: November 2022

Abstract
A pressurized water reactor primary environment can have a deleterious effect on the fatigue lifetime of austenitic stainless steels. There is a need to develop a greater understanding behind the effect of a pressurized water reactor primary environment on the fatigue behaviour of austenitic stainless steels. One of the ways that we can improve our mechanistic understanding is by carrying out striation spacing analysis.
Striation counting is a widely used technique in fatigue failure investigations where it is typically used to infer information on crack progression, including the estimation of propagation rates and number of applied loading cycles. Standardised procedures for performing striation counting are uncommon, especially for environmental fatigue in a high temperature pressurized water reactor primary water environment where differences in fracture surface morphology and oxide coverage can lead to additional complications in performing an analysis.
One of the main goals of the EU Horizon 2020 INCEFA-SCALE project is to develop an improved mechanistic understanding of fatigue in these systems through extensive characterisation of laboratory tested specimens. As part of this work, this paper describes the development of a standardised and robust striation counting procedure for the low cycle fatigue of austenitic stainless steels operating in both air and simulated pressurized water reactor environments. Additionally, results are presented from round robin exercises that involved eight partners of the INCEFA-SCALE consortium.
Research on Defect Detection of Fully-Wrapped Carbon Fiber Reinforced Hydrogen Storage Cylinder With an Aluminum Liner by Industrial Computed Tomography
Authors: Shi Yan , Tang Ping , Miao Cunjian , Ling Zhangwei , Guo Weican , Yu Xuefen 
Published: November 2022

Abstract
Currently, on-board storage cylinders of compressed hydrogen for land vehicles primarily use fully-wrapped carbon fiber reinforced cylinders with an aluminum liner. Due to the multi-layer structure of the hydrogen storage cylinder, nondestructive testing of the cylinder is facing great challenges and the nondestructive testing methods given in the standard are mainly internal and external surface testing by using visual inspection or an endoscope, causing that many internal defects cannot be identified. Industrial computed tomography is able to intuitively display three-dimensional information of the examined object, and thus this technology is expected to detect internal defects of the cylinders. In this study, the loading system of the cylinder, including limit plates, support blocks and support columns, was designed and manufactured. The industrial computed tomography test method with the use of a filter was established, and the delamination defects at the cylinder neck, shoulder, and cylindrical shell were systematically researched. It was found that the delamination defect width at the neck was the largest, followed by the defect width at the shoulder, and the defect width at the cylindrical shell was the smallest. In addition, the whole cylinder was detected by using spiral scan, demonstrating that this test method had the potential to be a common tool to monitor the cylinder defects.
Prediction Concept of Ratchet-Induced Collapse Under Deadweight and Seismic Loading
Authors: Kai Satoru , Ichimiya Masakazu , Kasahara Naoto 
Published: November 2022

Abstract
The failure mode estimation of essential components in nuclear facilities under beyond design-basis events (BDBEs) is necessary to mitigate the consequences during severe accident conditions. The plastic collapse induced by ratcheting, defined as the ratchet-induced collapse in this study, is one of the failure modes of piping components under seismic loading. This failure mode was first confirmed in the Pipe-fitting dynamic reliability program (PFDRP) conducted by EPRI in the 1980s. However, the mechanism and occurrence condition of this failure remained unclear for decades because there were no methods to express the continuous transition of failure modes under seismic loading, as ratcheting turned into a plastic collapse behavior in the experiment. In this study, the mechanism of the ratchet-induced collapse is clarified using numerical analyses and experimental tests. The X-Y trajectory representing the transition of the stress levels of deadweight and seismic loading is introduced to express the significant effect of ratcheting. The seismic failure mode map, which has a similar classification of stresses with Bree’s diagram, is also extended to represent the occurrence condition of plastic collapse. The prediction method of the ratchet-induced collapse is proposed by combining the X-Y trajectory and the extended seismic failure mode map.