bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuronal density and expression of calcium‐binding proteins across the layers of the superior colliculus in the common marmoset (Callithrix jacchus)
Authors: Chong Melissa H. Y. , Worthy Katrina H. , Rosa Marcello G. P. , Atapour Nafiseh 
Published: July 2022

AbstractThe superior colliculus (SC) is a layered midbrain structure with functions that include polysensory and sensorimotor integration. Here, we describe the distribution of different immunohistochemically identified classes of neurons in the SC of adult marmoset monkeys (Callithrix jacchus). Neuronal nuclei (NeuN) staining was used to determine the overall neuronal density in the different SC layers. In addition, we studied the distribution of neurons expressing different calcium‐binding proteins (calbindin [CB], parvalbumin [PV] and calretinin [CR]). Our results indicate that neuronal density in the SC decreases from superficial to deep layers. Although the neuronal density within the same layer varies little across the mediolateral axis, it tends to be lower at rostral levels, compared to caudal levels. Cells expressing different calcium‐binding proteins display differential gradients of density according to depth. Both CB‐ and CR‐expressing neurons show markedly higher densities in the stratum griseum superficiale (SGS), compared to the stratum opticum and intermediate and deep layers. However, CR‐expressing neurons are twice as common as CB‐expressing neurons outside the SGS. The distribution of PV‐expressing cells follows a shallow density gradient from superficial to deep layers. When normalized relative to total neuronal density, the proportion of CR‐expressing neurons increases between the superficial and intermediate layers, whereas that of CB‐expressing neurons declines toward the deep layers. The proportion of PV‐expressing neurons remains constant across layers. Our data provide layer‐specific and accurate estimates of neuronal density, which may be important for the generation of biophysical models of how the primate SC transforms sensory inputs into motor signals.
Bio‐oil upgrading via ketonization of carboxylic acids on Na promoted Ca/AlOx catalysts
Authors: Wang Zichun , Arstad Bjørnar , Wang Leizhi , Ling Huajuan , Shi Jeffrey , Stampfl Catherine , Jiang Yijiao , Huang Jun 
Published: July 2022

AbstractKetonization of carboxylic acids is valuable for bio‐oil upgrading and producing bio‐derived chemicals. Ca/AlOx metal oxides with various Ca/Al ratios have been prepared by the low‐cost and natural abundant metals in the process. The addition of alkaline or alkaline‐earth metals could significantly improve the activity of Ca/AlOx catalysts by base‐catalyzed ketonization of carboxylic acids. However, the active sites on alkaline‐metal‐doped Ca/AlOx catalysts are still under debate, and the commercialization of these catalysts often suffers from deactivation in long‐term use. Here Ca(Na)/AlOx catalysts with various Ca/Al molar ratios were prepared and evaluated for the ketonization of acetic acid. Sodium addition resulting in the formation of NaAlO2 has higher basicity than CaO. These strong basic sites could significantly promote the ketonization of acetic acid via the thermal decomposition of carboxylates. The Ca(Na)/AlOx catalyst with NaAlO2 populated on the surface could provide 100% acetone selectivity at the complete conversion of acetic acid at 400°C and exhibit no activity loss after a 400 h reaction, which is the most active and stable catalyst for ketonization reaction hitherto. These Ca(Na)/AlOx catalysts are also stable by adding major bio‐oil model compounds (e.g., phenol) into the reaction mixture, which are promising for future bio‐oil upgrading applications.
Parallel computational tree logic model‐checking on pushdown systems
Authors: Ye Xin , Shi Jianqi , Huang Yanhong , Li Qin , Wei Hansheng , Chen Xinyu 
Published: July 2022

SummaryModel checking and static analysis have been well studied for program verification. Because of the ability to describe the stack, the pushdown system (PDS) has become a perfect model that is able to accurately model procedure calls and mimic the program's stack. Thus, it is not only a good model for sequential programs but for malware detection as well. However, with the increase of the complexity of programs, the size of models becomes huge as well. Thus, the model‐checking problem is expensive to solve. The computational tree logic (CTL) is a widely used logic and its model checking problem of PDSs can be reduced to the emptiness analysis of an alternating Büchi pushdown system (ABPDS) by determining whether there is an accepting run. When the size of a PDS is huge, the computations can be time‐consuming. To overcome this limitation, we propose a parallel solution. We propose a parallel framework based on the Compute Unified Device Architecture and the corresponding parallel algorithms to solve the emptiness problem of ABPDSs. Moreover, in order to effectively utilize the graphics processing unit, we design a new data structure of variables and an algorithm of management of thread scheduling for the parallel model. We implement our algorithms in a tool and compare our tool to a CTL model checker for PDS as a benchmark. The comparison results indicate an encouraging performance speedup.
Environmental, social and governance ratings and firm performance: The moderating role of internal control quality
Authors: Boulhaga Mounia , Bouri Abdelfettah , Elamer Ahmed A. , Ibrahim Bassam A. 
Published: July 2022

AbstractDespite the burgeoning interest in environmental, social and governance (ESG) ratings, current results regarding ESG rating‐performance relationship are inconclusive. Since what affects this disagreement is ambiguous, we examine how internal control weaknesses (ICW) may affect the relationship between ESG rating and a firm's performance. In fact, employing a sample of French listed firms during the period between 2012 and 2018, we predicted and found that both ICW and ESG ratings have a positive and significant influence on a firm's performance. In addition, the results indicate that ICW negatively and significantly moderates the relationship between ESG ratings and corporate performance. Moreover, the robustness of the results is checked through the generalized method of moments regression. We also offer theoretical and practical implications to drive policymakers and businesses to assure sustainable development. We expect that our study can help managers to strengthen their internal resources, such as the internal control (IC) and ESG ratings to improve a firm's performance.
Therapeutic induction of Bcl2‐associated athanogene 3‐mediated autophagy in idiopathic pulmonary fibrosis
Authors: Chillappagari Shashipavan , Schwarz Julian , Kesireddy Vidyasagar , Knoell Jessica , Korfei Martina , Hoetzenecker Konrad , Schmitz M. Lienhard , Behl Christian , Bellusci Saverio , Guenther Andreas , Mahavadi Poornima 
Published: July 2022

AbstractBackgroundExaggerated fibroblast proliferation is a well‐known feature in idiopathic pulmonary fibrosis (IPF) which may be – in part – due to insufficient autophagy, a lysosome dependent cellular surveillance pathway. Bcl2‐associated athanogene 3 (BAG3) is a pivotal co‐chaperone of the autophagy pathway. Here, we studied whether therapeutic modulation of BAG3‐mediated autophagy can rescue insufficient autophagy and impact IPF fibroblast proliferation.MethodsPrimary interstitial fibroblasts or precision cut lung slices (PCLS) of IPF lungs were treated with (1) the antifibrotic drug pirfenidone (Pirf), (2) the demethylating agent 5‐azacytidine (Aza), (3) the BAG3 modulator cantharidin (Ctd). Autophagy flux was measured following pretreatment with the autophagy inhibitors or by GFP‐RFP‐LC3B transfection followed by drug treatments. Proliferation was measured by 5‐bromo‐2′‐deoxyuridine assay. BAG3, filamin C (FLNC), proliferating‐cell‐nuclear‐antigen (PCNA), collagen1A1 (COL1A1) and autophagy proteins were assessed by immunoblotting or immunofluorescence. Loss of function experiments were performed by siRNA mediated knockdown of BAG3.ResultsIn comparison with healthy donors, increased BAG3 protein was observed in IPF lung homogenates and IPF fibroblasts. In addition, the substrate of BAG3‐mediated autophagy, FLNC, was increased in IPF fibroblasts, implying insufficient activation of BAG3‐dependent autophagy. Therapeutic modulation of this pathway using Aza and Ctd alone or in combination with the IPF therapy drug Pirf rescued the insufficient BAG3‐mediated autophagy and decreased fibroblast proliferation. Such effects were observed upon therapeutic modulation of BAG3 but not upon knock down of BAG3 per se in IPF fibroblasts. Similarly, PCLS of IPF patients showed a significant decrease in collagen deposition in response to these drugs, either alone or in a more potent form in combination with Pirf.ConclusionsOur study reveals that repurposing drugs that modulate autophagy regulating proteins render therapeutic benefits in IPF. Fine tuning of this pathway may hence signify a promising therapeutic strategy to ameliorate antifibrotic properties and augment the efficacy of current IPF therapy.
Ex‐vivo investigation of radiofrequency ablation in pancreatic adenocarcinoma after neoadjuvant chemotherapy
Authors: Rossi Gemma , Petrone Maria Chiara , Schiavo Lena Marco , Albarello Luca , Palumbo Diego , Testoni Sabrina Gloria Giulia , Archibugi Livia , Tacelli Matteo , Zaccari Piera , Vanella Giuseppe , Apadula Laura , Crippa Stefano , Belfiori Giulio , Reni Michele , Falconi Massimo , Doglioni Claudio , De Cobelli Francesco , Healey Andrew J , Capurso Gabriele , Arcidiacono Paolo Giorgio 
Published: July 2022

AbstractObjectiveEndoscopic ultrasound (US)‐guided radiofrequency ablation (RFA) has been investigated for pancreatic ductal adenocarcinoma (PDAC) but studies are limited and heterogeneous. Computed tomography (CT) scan features may predict RFA response after chemotherapy but their role is unexplored. The primary aim was to investigate the efficacy of ex‐vivo application of a dedicated RFA system at three power on surgically resected PDAC in patients who underwent neoadjuvant chemotherapy. The secondary aim was to explore the association between pre‐treatment CT‐based quantitative features and RFA response.MethodsFifteen ex‐vivo PDAC samples were treated by RFA under US control at three power groups (10, 30, and 50 W). Short axis necrosis diameter was measured by two expert blinded pathologists as the primary outcome. Two radiologists independently reviewed preoperative CT images.ResultsEighty percent of specimens showed coagulative necrosis consisting of few millimeters: 5.7 ± 3.9 mm at 10 W, 3.7 ± 2.2 mm at 30 W, and 3.5 ± 2.4 mm at 50 W (p = 0.3), without a significant correlation between power setting and mean necrosis short axis (rho = –0.28; p = 0.30). Good agreement was seen between pathologists (k = 0.76; 95% confidence interval 0.55–0.98). Logistic regression analysis did not show associations between CT features and RFA response.ConclusionsRFA causes histologically evident damage with coagulative necrosis of a few millimeters in 80% of ex‐vivo PDAC samples after chemotherapy and no clinical or pre‐operative CT features can predict efficacy. Power settings do not correlate with the histological ablation area. These results are of relevance when employing RFA in vivo and planning clinical trials on its role in PDAC patients.
Perovskite semiconductors for ionizing radiation detection
Authors: Hu Hao , Niu Guangda , Zheng Zhiping , Xu Ling , Liu Linyue , Tang Jiang 
Published: July 2022

AbstractThe detection of ionizing radiation such as X‐ray, γ‐ray, α‐particle, and neutrons has been widely required in medical and industrial areas. Perovskite semiconductor detectors are arousing widespread interest and achieving significant progresses in this area. Unique material strengths, such as large attenuation coefficient, defect tolerant nature, balanced carrier mobilities, and feasible preparation techniques, make perovskite semiconductor detector a strong competitor to existing commercial products. Inspired by the booming development of this area, we review the current achievements of ionizing radiation detection with perovskite semiconductors. Firstly, a comprehensive summary of the device preparation techniques is provided, followed by a profound discussion of the detector physics. Then, the broad applications of perovskite semiconductor detectors are illustrated. Finally, we give an outlook of the current challenges pending to be tackled for commercialized applications. We believe the perovskite semiconductor detectors will be new blood to the current ionizing radiation detection market.image
Partial deoxygenation of pyrolysis intermediates toward fossil fuel miscible bioliquids
Authors: Santander José A. , Diez Alejandra , Gutierrez Victoria , Volpe María Alicia 
Published: July 2022

AbstractCatalytic fast pyrolysis of sunflower seed shells was performed using a two‐stage fixed bed reactor to produce partially deoxygenated bio‐oils. Ketonization and aldol condensation reactions were performed in a dual bed reactor using a CeO2 catalyst followed by a bifunctional Cu/Ni/ZrO2 catalyst. An ethanol‐saturated N2 stream was supplied to increase the H/C ratio of the pyrolysis intermediates. The oxygen content decreased from 23 to 13 wt % over the CeO2 fixed‐bed due to the almost complete conversion of methoxy phenols and the formation of ketones and alkyl‐substituted phenols. The Cu/Ni/ZrO2 catalyst in the presence of ethanol vapor increased the fraction of alkanes in the condensed product and favored the formation of larger ketones and higher molecular weight species. Miscibility tests showed that the partially upgraded bio‐oil could be homogeneously blended with fossil fuel oil in a 1:4 mass ratio. The oily fraction of the non‐catalytic pyrolysis bioliquid (oxygen content up to 23 wt %) was also partially miscible with the petroleum‐derived fuel.
The age‐related changes in 40 Hz Auditory Steady‐State Response and sustained Event‐Related Fields to the same amplitude‐modulated tones in typically developing children: A magnetoencephalography study
Authors: Arutiunian Vardan , Arcara Giorgio , Buyanova Irina , Gomozova Militina , Dragoy Olga 
Published: July 2022

AbstractRecent studies have revealed that gamma‐band oscillatory and transient evoked potentials may change with age during childhood. It is hypothesized that these changes can be associated with a maturation of GABAergic neurotransmission and, subsequently, the age‐related changes of excitation–inhibition balance in the neural circuits. One of the reliable paradigms for investigating these effects in the auditory cortex is 40 Hz Auditory Steady‐State Response (ASSR), where participants are presented with the periodic auditory stimuli. It is known that such stimuli evoke two types of responses in magnetoencephalography (MEG)—40 Hz steady‐state gamma response (or 40 Hz ASSR) and auditory evoked response called sustained Event‐Related Field (ERF). Although several studies have been conducted in children, focusing on the changes of 40 Hz ASSR with age, almost nothing is known about the age‐related changes of the sustained ERF to the same periodic stimuli and their relationships with changes in the gamma strength. Using MEG, we investigated the association between 40 Hz steady‐state gamma response and sustained ERF response to the same stimuli and also their age‐related changes in the group of 30 typically developing 7‐to‐12‐year‐old children. The results revealed a tight relationship between 40 Hz ASSR and ERF, indicating that the age‐related increase in strength of 40 Hz ASSR was associated with the age‐related decrease of the amplitude of ERF. These effects were discussed in the light of the maturation of the GABAergic system and excitation–inhibition balance development, which may contribute to the changes in ASSR and ERF.
Hepatic patatin‐like phospholipase domain‐containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans
Authors: Ericson Elke , Bergenholm Linnéa , Andréasson Anne‐Christine , Dix Carly I. , Knöchel Jane , Hansson Sara F. , Lee Richard , Schumi Jennifer , Antonsson Madeleine , Fjellström Ola , Nasr Patrik , Liljeblad Mathias , Carlsson Björn , Kechagias Stergios , Lindén Daniel , Ekstedt Mattias 
Published: July 2022

Abstract
In nonalcoholic fatty liver disease (NAFLD) the patatin‐like phospholipase domain‐containing 3 (PNPLA3) rs738409 variant is a contributor. In mice, the Pnpla3 148M variant accumulates on lipid droplets and probably leads to sequestration of a lipase cofactor leading to impaired mobilization of triglycerides. To advance our understanding of the localization and abundance of PNPLA3 protein in humans, we used liver biopsies from patients with NAFLD to investigate the link to NAFLD and the PNPLA3 148M genotype. We experimentally qualified an antibody against human PNPLA3. Hepatic PNPLA3 protein fractional area and localization were determined by immunohistochemistry in biopsies from a well‐characterized NAFLD cohort of 67 patients. Potential differences in hepatic PNPLA3 protein levels among patients related to degree of steatosis, lobular inflammation, ballooning, and fibrosis, and PNPLA3 I148M gene variants were assessed. Immunohistochemistry staining in biopsies from patients with NAFLD showed that hepatic PNPLA3 protein was predominantly localized to the membranes of small and large lipid droplets in hepatocytes. PNPLA3 protein levels correlated strongly with steatosis grade (p = 0.000027) and were also significantly higher in patients with lobular inflammation (p = 0.009), ballooning (p = 0.022), and significant fibrosis (stage 2–4, p = 0.014). In addition, PNPLA3 levels were higher in PNPLA3 rs738409 148M (CG, GG) risk allele carriers compared to 148I (CC) nonrisk allele carriers (p = 0.0029). Conclusion: PNPLA3 protein levels were associated with increased hepatic lipid content and disease severity in patients with NAFLD and were higher in PNPLA3 rs738409 (148M) risk allele carriers. Our hypothesis that increased hepatic levels of PNPLA3 may be part of the pathophysiological mechanism of NAFLD is supported.
Toward a non‐organizational theory of human resource management? A complex adaptive systems perspective on the human resource management ecosystem in (con)temporary organizing
Authors: Burke Catriona M. , Morley Michael J. 
Published: July 2022

AbstractThe emergence of the temporary organization has ushered in a new logic of organizing accompanied by paradigm‐shifting challenges with respect to how the evolving nature of work, workers, and collective effort are to be understood. To capture the complexity inherent in this new order, and to broaden our focus from the organization to the enfolding ecosystem within which temporary organizing must be situated and understood, we engage in problematization to develop a multi‐level framework for theorizing the contemporary human resource management ecosystem. Curating insights from complexity science, we conceptualize this ecosystem as a complex adaptive one and we propose a framework that integrates key structural (open boundaries and relational constitution), emergent (contextual and complex causality), and temporal (dynamic and adaptive) properties. To deepen lines of inquiry around these defining elements, we advance a series of propositions for testing, and we outline a range of theoretical, methodological, and practical implications that arise from our work.
The advanced lung cancer inflammation index is the optimal inflammatory biomarker of overall survival in patients with lung cancer
Authors: Song Mengmeng , Zhang Qi , Song Chunhua , Liu Tong , Zhang Xi , Ruan Guotian , Tang Meng , Xie Hailun , Zhang Heyang , Ge Yizhong , Li Xiangrui , Zhang Kangping , Yang Ming , Li Qinqin , Liu Xiaoyue , Lin Shiqi , Xu Yu , Xu Hongxia , Wang Kunhua , Li Wei , Shi Hanping 
Published: July 2022

AbstractBackgroundsMalnutrition and systemic inflammatory responses are associated with poor overall survival (OS) in lung cancer patients, but it remains unclear which biomarkers are better for predicting their prognosis. This study tried to determine the best one among the existing common nutrition/inflammation‐based indicators of OS for patients with lung cancer.Materials and methodsThere were 16 nutrition or systemic inflammation‐based indicators included in this study. The cut‐off points for the indicators were calculated using maximally selected rank statistics. The OS was evaluated using the Kaplan–Meier estimator, and univariate and multivariate Cox proportional hazard models were used to determine the relationship between the indicators and OS. A time‐dependent receiver operating characteristic curves (time‐ROC) and C‐index were calculated to assess the predictive ability of the different indicators.ResultsThere were 1772 patients with lung cancer included in this study. In univariate analysis, all 16 indicators were significantly associated with OS of the patients (all P < 0.001). Except for platelet‐to‐lymphocyte ratio, all other indicators were independent predictors of OS in multivariate analysis (all P < 0.05). Low advanced lung cancer inflammation index (ALI) was associated with higher mortality risk of lung cancer [hazard ratio, 1.30; 95% confidence interval (CI), 1.13–1.49]. The results of the time‐AUC and C‐index analyses indicated that the ALI (C‐index: 0.611) had the best predictive ability on the OS in patients with lung cancer. In different sub‐groups, the ALI was the best indicator for predicting the OS of lung cancer patients regardless of sex (C‐index, 0.609 for men and 0.613 for women) or smoking status (C‐index, 0.629 for non‐smoker and 0.601 for smoker) and in patients aged <65 years (C‐index, 0.613). However, the modified Glasgow prognostic score was superior to the other indicators in non‐small cell lung cancer patients (C‐index, 0.639) or patients aged ≥65 years (C‐index, 0.610), and the glucose‐to‐lymphocyte ratio performed better prognostic ability in patients with small cell lung cancer (C‐index, 0.601).ConclusionsThe prognostic ability of the ALI is superior to the other inflammation/nutrition‐based indicators for all patients with lung cancer.
Toward understanding the regioselectivity of the one‐pot reaction of phenylene diamines with aldehydes and cyclopentadiene (Povarov reaction). Combined experimental and theoretical approaches
Authors: Savchenko Rimma G. , Limantceva Regina M. , Khursan Sergey L. , Mesheriakova Kathetine S. , Tolstikov Alexander G. , Odinokov Victor N. 
Published: July 2022

AbstractThree‐component acid‐catalyzed cyclocondensation of isomeric phenylenediamines with aldehydes and cyclopentadiene (CPD) was studied. In the M06‐2X//B3LYP/6–311 + G(d,p) + IEFPCM(SMD) approximation, a quantum chemical model was developed, energies of the PES stationary points were determined, and activation barriers were found for the CPD addition to the protonated Schiff base (rate‐limiting step) and for electrophilic carbocation cyclization to give endo, endo (syn)‐ or endo, exo (anti)‐cyclopentene‐annulated octahydropyridoquinoline‐ and octahydrophenanthroline‐based cycloadducts. The calculation results are in full agreement with the experimental data, which indicate that the cyclocondensation involving p‐phenylenediamine affords both types of cycloadducts, whereas the reactions of o‐ or m‐phenylenediamine lead to regioselective formation of octahydro‐1,10‐phenanthroline‐ or octahydropyridoquinoline‐based product, respectively. According to homo‐ and heteronuclear correlation 1Н and 13С NMR experiments and X‐ray diffraction data, the newly formed asymmetric centers of the cyclopentene‐annulated tetrahydroquinoline moiety in the polycyclic products have exo (endo)‐cis‐orientation.