bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hysteresis and Surface Shear Stresses During Snow-Particle Aeolian Transportation
Authors: Niiya Hirofumi , Nishimura Kouichi 
Published: February 2022

AbstractSurface shear stresses produced by wind and particle collision play a key role in aerodynamic entrainment and splash processes. The fluid shear stress at the surface during aeolian transport has been researched for decades; however, the equilibrium property reported in the literature, numerical simulations, and experiments is inconsistent. To discuss this discrepancy, this study investigates fluid and particle shear stresses at the surface during the aeolian transport of snow particles using a two-dimensional random-flight model of drifting snow. The simulations are performed for various friction velocities on a loose snow bed. By varying the wind conditions in stages, the transport hysteresis is confirmed, and the impact threshold is estimated from the particle transport rate ($$0.206\,\hbox {m\,s}^{-1}$$0.206ms-1). The friction velocity at the surface during transport decreases marginally with an increase in wind speed caused by the impact threshold, revealing that our results do not contradict Owen’s second hypothesis. The total shear stress, which is calculated by summing the fluid and particle shear stresses, is vertically uniform in the equilibrium state; thus, the increase in the particle shear stress decreases the fluid shear stress at the surface. The equilibrium property of the fluid shear stress near the surface changes significantly with height (from a decreasing trend to an increasing trend) because the particle shear stress decreases rapidly in the height range of 1–10 mm. Our findings suggest that it is difficult to accurately measure the fluid shear stress in the surface vicinity using anemometers, and a new methodology is needed.
Afatinib alone and in combination with vinorelbine or paclitaxel, in patients with HER2-positive breast cancer who failed or progressed on prior trastuzumab and/or lapatinib (LUX-Breast 2): an open-label, multicenter, phase II trial
Authors: Hickish Tamas , Mehta Ajay , Liu Mei-Ching , Huang Chiun-Sheng , Arora Rajendra Singh , Chang Yuan-Ching , Yang Youngsen , Vladimirov Vladimir , Jain Minish , Tsang Janice , Pemberton Karine , Sadrolhefazi Behbood , Jin Xidong , Tseng Ling-Ming 
Published: February 2022

Abstract
Purpose
Resistance to HER2 (ErbB2)-targeted therapy may be mediated by other members of the ErbB family. We investigated the efficacy and safety of the irreversible ErbB family blocker, afatinib, alone as first-line therapy in the advanced setting and in combination with vinorelbine or paclitaxel for those who progressed on afatinib monotherapy, in female patients with metastatic breast cancer who had failed or progressed on prior HER2-targeted therapy in the early disease setting.

Methods
In this phase II, single-arm, two-part study (ClinicalTrials.gov: NCT01271725), patients in part A received afatinib 40 mg/day in 21-day cycles until disease progression or intolerable adverse events (AEs). Patients with progressive disease could then receive afatinib plus weekly vinorelbine 25 mg/m2 or paclitaxel 80 mg/m2 until disease progression or intolerable AEs (part B). The primary endpoint was confirmed objective response rate (RECIST v1.1).

Results
Eighty-seven patients were enrolled and 74 were treated in part A (median age: 51 years [range 27–76]; 31 [42%] estrogen receptor-positive, 26 [35%] progesterone receptor-positive). Of these, 39 (53%) patients went on to receive afatinib plus vinorelbine (13 patients) or paclitaxel (26 patients) in part B. Thirteen (18%) and 12 (31%) patients achieved an objective response in parts A and B, respectively. The most common treatment-related AEs with afatinib monotherapy (any/grade ≥ 3) were diarrhea (68%/8%) and rash (49%/4%). Combination therapy was generally well tolerated, with no additive toxicity observed.

Conclusion
Afatinib treatment, alone or in combination with vinorelbine or paclitaxel, was associated with objective responses in ≥ 18% of patients with metastatic breast cancer for whom prior HER2-targeted therapy has failed. Treatment-related AEs were generally manageable, with few grade ≥ 3 AEs reported.

Trial registration
ClinicalTrials.gov, NCT01271725, registered 1 July 2011.
The semantically annotated corpus of Polish quantificational expressions
Authors: Szymanik Jakub , Kieraś Witold 
Published: February 2022

AbstractThe paper presents a manually annotated corpus of Polish quantificational expressions. The quantifier annotation was conducted on top of existing gold-standard data for Polish as its separate layer. This paper releases the data and gives an overview of the corpus and related tools. As far as we know, this is the first large-scale annotation of generalized quantifiers together with their crucial semantic properties, including monotonicity profile. We also discuss the potential further use of the corpus in linguistics and cognitive science.
Uniqueness of the inversive plane of order sixty-four
Authors: Penttila Tim 
Published: February 2022

AbstractThe uniqueness of the inversive plane of order sixty-four, up to isomorphism, is established. Equivalently, it is shown that every ovoid of $$\mathrm{PG}(3,64)$$

PG
(
3
,
64
)

is an elliptic quadric.
Balancing control and autonomy in master surgery scheduling: Benefits of ICU quotas for recovery units
Authors: Heider Steffen , Schoenfelder Jan , Koperna Thomas , Brunner Jens O. 
Published: February 2022

AbstractWhen scheduling surgeries in the operating theater, not only the resources within the operating theater have to be considered but also those in downstream units, e.g., the intensive care unit and regular bed wards of each medical specialty. We present an extension to the master surgery schedule, where the capacity for surgeries on ICU patients is controlled by introducing downstream-dependent block types – one for both ICU and ward patients and one where surgeries on ICU patients must not be performed. The goal is to provide better control over post-surgery patient flows through the hospital while preserving each medical specialty’s autonomy over its operational surgery scheduling. We propose a mixed-integer program to determine the allocation of the new block types within either a given or a new master surgery schedule to minimize the maximum workload in downstream units. Using a simulation model supported by seven years of data from the University Hospital Augsburg, we show that the maximum workload in the intensive care unit can be reduced by up to 11.22% with our approach while maintaining the existing master surgery schedule. We also show that our approach can achieve up to 79.85% of the maximum workload reduction in the intensive care unit that would result from a fully centralized approach. We analyze various hospital setting instances to show the generalizability of our results. Furthermore, we provide insights and data analysis from the implementation of a quota system at the University Hospital Augsburg.
Rate adaptive pacing in people with chronic heart failure increases peak heart rate but not peak exercise capacity: a systematic review
Authors: Clark H. I. , Pearson M. J. , Smart N. A. 
Published: February 2022

AbstractRate adaptive cardiac pacing (RAP) allows increased heart rate (HR) in response to metabolic demand in people with implantable electronic cardiac devices (IECD). The aim of this work was to conduct a systematic review to determine if RAP increases peak exercise capacity (peak VO2) in line with peak HR in people with chronic heart failure. We conducted a systematic literature search from 1980, when IECD and RAP were first introduced, until 31 July 2021. Databases searched include PubMed, Medline, EMBASE, EBSCO, and the Clinical Trials Register. A comprehensive search of the literature produced a total of 246 possible studies; of these, 14 studies were included. Studies and subsequent analyses were segregated according to comparison, specifically standard RAP (RAPON) vs fixed rate pacing (RAPOFF), and tailored RAP (TLD RAPON) vs standard RAP (RAPON). Pooled analyses were conducted for peak VO2 and peak HR for RAPON vs RAPOFF. Peak HR significantly increased by 15 bpm with RAPON compared to RAPOFF (95%CI, 7.98–21.97, P < 0.0001). There was no significant difference between pacing mode for peak VO2 0.45 ml kg−1 min−1 (95%CI, − 0.55–1.47, P = 0.38). This systematic review revealed RAP increased peak HR in people with CHF; however, there was no concomitant improvement in peak VO2. Rather RAP may provide benefits at submaximal intensities by controlling the rise in HR to optimise cardiac output at lower workloads. HR may be an important outcome of CHF management, reflecting myocardial efficiency.
Technological Innovation, Sustainable Green Practices and SMEs Sustainable Performance in Times of Crisis (COVID-19 pandemic)
Authors: Alraja Mansour Naser , Imran Rabia , Khashab Basel M. , Shah Mahmood 
Published: February 2022

AbstractCOVID-19 restrictions significantly affected SMEs, which have faced many challenges to their sustainability within this fragile new environment. This study proposes a holistic framework of sustainable performance by interrelating factors showing robust associations to produce this effect' for achieving sustainable performance in SMEs, through integrating the Technology Organisation Environment (TOE) and Resource Based View (RBV) models, to test how sustainable green practices can process the TOE factors when affecting sustainable performance. The research focuses on SMEs with worldwide employees and involves data collected from a range of different employees belonging to four different managerial levels. The process incorporated the analysis of 669 questionnaires to test the proposed hypotheses using structural equation modeling. Findings suggest that, together, TOE factors represent crucial inputs for green practices such as green training, green performance appraisal, that, in turn, mean critical processes lead to sustainable performance (output). Additionally, the findings should also inspire SMEs to focus even more effort on internal technological and organisational factors and to encourage an eco-friendly culture that would demand stakeholders adopt a more positive environmental stance.
Autistic Children Quickly Orient Away from Both Eyes and Mouths During Face Observation
Authors: Jónsdóttir Lilja Kristín , Neufeld Janina , Falck-Ytter Terje , Kleberg Johan Lundin 
Published: February 2022

AbstractStudies have supported two different hypotheses of reduced eye gaze in people with ASD; gaze avoidance and gaze indifference, while less is known about the role of anxiety. We tested these hypotheses using an eye-tracking paradigm that cued the eyes or mouth of emotional faces. Autistic children (n = 12, mean age 7 years) looked faster away from both eyes and mouths than controls (n = 22). This effect was not explained by anxiety symptoms. No difference was found in latency towards either area. These results indicate that attentional avoidance of autistic children is not specific to eyes, and that they do not show attentional indifference to eyes compared to controls. Atypicalities in visual scanning in ASD are possibly unrelated to specific facial areas.
Navigating the internationalization process: Strategic resources for early internationalizing firms
Authors: Breuillot Angélique , Bocquet Rachel , Favre-Bonté Véronique 
Published: February 2022

AbstractDespite an increasing number of studies identifying factors that influence the internationalization process for early internationalizing firms (EIFs), it remains unclear which of these numerous factors could play a strategic role and, more specifically, when. This paper develops a new conceptual framework anchored in the resource-based view to identify strategic resources that can explain EIFs’ internationalization process accurately over time. Building on a systematic literature review based on 102 papers covering a period of 29 years, we methodically present a phase-by-phase observation of EIFs’ internationalization process to identify the strategic relevance of different influential resources. The results highlight the importance of the shift from individual to organizational resources, which occurs at a critical phase of transition from the entry to the post-entry phase. Studying the evolution of strategic resources along four phases allows us to determine that the progress of EIFs through the phases of their internationalization process is closely linked to their resources’ development process. This study suggests some promising research avenues, at theoretical and methodological levels, and results in a series of concrete recommendations intended for entrepreneurs and/or managers of EIFs.
The Impact of Modifying Interpretive Bias on Contamination-Related Obsessive–Compulsive Symptoms
Authors: Wong Shiu F. , Scharfenberg Angela , Krause Sandra , Grisham Jessica R. 
Published: February 2022

AbstractCognitive-behavioural models of obsessive–compulsive disorder (OCD) propose that a tendency to negatively interpret ambiguous thoughts and situations plays a key role in maintaining the disorder. Moreover, some researchers have proposed that negative interpretive biases may share a common processing mechanism with attentional biases, with changes in one predicted to lead to changes in the other. The current study examined whether training positive (i.e., adaptive) interpretive bias of contamination-related OCD concerns using a cognitive bias modification paradigm (CBM-I) would lead to reductions in contamination concerns, as well as changes in contamination-related attentional bias. Undergraduate students with high levels of contamination-related OCD symptoms were randomly assigned to receive either positive (n = 31) or neutral (n = 33) CBM-I training. Participants in the positive training condition, relative to the neutral training condition, showed a significantly greater increase in positive interpretive bias, significantly less within-session behavioural avoidance of contaminants, and significantly reduced contamination-related cognitions (at one-week follow-up). Contrary to expectations, CBM-I training did not differentially impact attentional bias nor self-reported contamination-related OCD symptoms. We discuss future directions in applying CBM-I to contamination-related OCD.
Vaccine Hesitancy and Fear of COVID-19 Among Italian Medical Students: A Cross-Sectional Study
Authors: Lo Moro Giuseppina , Cugudda Eleonora , Bert Fabrizio , Raco Immacolata , Siliquini Roberta 
Published: February 2022

AbstractMedical students are in close contact with patients and should adhere to the same recommendations as healthcare workers. The study aimed to explore medical students' hesitancy towards COVID-19 vaccine and evaluate fear of COVID-19 and its relationship with hesitancy. A cross-sectional survey was conducted amongst a sample of medical students attending clinical years (November 2020–February 2021, Italy). Multivariable regressions were performed (p < 0.05 as significant). A total of 929 students participated (58.6% of eligible students). Hesitancy was reported by 6.7%; extreme fear of COVID-19 by 42.0%. Among hesitancy predictors, there were the survey completion before COVID-19 vaccine authorisation (adjOR = 6.43), adverse reactions after a vaccination (adjOR = 3.30), and receiving advice against COVID-19 vaccination from a relative (adjOR = 2.40). Students who received the recommended paediatric vaccinations (adjOR = 0.10), students with higher adherence to preventive measures (adjOR = 0.98), and students with fear of contracting COVID-19 with regard to the health of loved ones (adjOR = 0.17) were less likely to be hesitant. Females (adjOR = 1.85), students with poor health (adjOR = 1.64), students who had a loved one severely affected by COVID-19 (adjOR = 1.68), and students with fear of contracting flu (adjOR = 3.06) had a higher likelihood of reporting extreme fear. Hesitancy was remarkably lower than in similar studies. However, there is room for improvement in university activities that could deepen the competence in vaccines. Our focus on fear should not be overlooked, since the extent of extreme fear that we found might represent a substantial burden, considering the associations between fear and other health outcomes.
The choice of efficiency benchmarking metric in evaluating firm productivity and viability
Authors: West S. C. , Mugera A. W. , Kingwell R. S. 
Published: February 2022

AbstractThe Debreu–Farrell measure of technical efficiency is widely used to benchmark firm performance. A limitation of this measure is that it is orientation restricted and evaluates the performance of a decision-making unit in an explicit direction relative to the best-practice frontier and not the most productive point on the frontier. Therefore, the measure does not provide policy insight on how to direct decision-making units to achieve the best possible productivity level. Taking a departure from conventional nonparametric benchmarking studies, this study benchmarks the performance of commercial farm businesses in the Western Australia’s wheatbelt region using total factor productivity efficiency (‘TFP efficiency’) and compares the results to those when the conventional technical efficiency measures are applied. We find that the two measures of firm performance differ and are influenced by different sources of firm heterogeneity. Therefore, derived policy insights and prescriptions also differ. This is an important insight that policymakers and practitioners need to be aware of.
The Effects of Childhood Trauma on College Completion
Authors: Lecy Natalie , Osteen Philip 
Published: February 2022

AbstractThis study uses the National Longitudinal Study of Adolescent to Adult Health to examine the effect of childhood trauma experiences on college graduation rates. A longitudinal mediation path analysis with a binary logistic regression is performed using trauma as a mediator between race, gender, first-generation status and college completion. The analysis reveals that being female and a continuing-generation student are both associated with greater likelihood of graduating college and that trauma mediates the relationship between race, gender, first-generation status and college completion. The authors explore the implications for these findings for policy, practice, and future research.
Correlation Between Biomass Burning Tracers in Urban and Rural Particles in Silesia—Case Study
Authors: Janoszka Katarzyna , Czaplicka Marianna 
Published: February 2022

AbstractThe major biomass burning tracers are thermal degradation products from the biopolymer cellulose, namely the didehydromonosaccharide derivatives levoglucosan, galactosan, and mannosan and the resin acid derivative dehydroabietic acid, with a minor contribution from β-sitosterol. Levoglucosan, galactosan, and mannosan were measured at two sites in Silesia, a rural (Rokitno) and industry region (Zabrze), during the winter of 2017/2018. The results showed that mean concentrations of the total tracers determined were 737 ng/m3 for Zabrze and 465 ng/m3 for Rokitno. Levoglucosan was the most abundant tracer; it was 83.2% of the determined tracers in Zabrze and 78.1% in Rokitno. The relative proportions of levoglucosan to mannosan have been used for source reconstruction of combustion-derived byproducts in atmospheric aerosols. The levoglucosan to mannosan ratio for Zabrze was 8.9 and for Rokitno 5.3; the levoglucosan to sum of mannosan and galactosan ratio was 6.2 and 3.8 for Zabrze and Rokitno, respectively. The correlation between tracers is high (0.73 to 0.97) and shows linearity. In order to compare the fuel type (by the coefficient of divergence (CD)) between different sites, the results from a previous work in health resort Krynica were used. The CD between Krynica and Rokitno as well as Krynica and Zabrze was equal to 0.633 and 0.712, respectively. The CD between Rokitno and Zabrze was equal to 0.175. Despite the biomass burning tracer measurements are mostly local, they have a huge impact on air pollution and climate changes.
Genomics and adaptation in forest ecosystems
Authors: Neophytou Charalambos , Heer Katrin , Milesi Pascal , Peter Martina , Pyhäjärvi Tanja , Westergren Marjana , Rellstab Christian , Gugerli Felix 
Published: February 2022

Abstract
Rapid human-induced environmental changes like climate warming represent a challenge for forest ecosystems. Due to their biological complexity and the long generation time of their keystone tree species, genetic adaptation in these ecosystems might not be fast enough to keep track with conditions changing at such a fast pace. The study of adaptation to environmental change and its genetic mechanisms is therefore key for ensuring a sustainable support and management of forests. The 4-day conference of the European Research Group EvolTree (https://www.evoltree.eu) on the topic of “Genomics and Adaptation in Forest Ecosystems” brought together over 130 scientists to present and discuss the latest developments and findings in forest evolutionary research. Genomic studies in forest trees have long been hampered by the lack of high-quality genomics resources and affordable genotyping methods. This has dramatically changed in the last few years; the conference impressively showed how such tools are now being applied to study past demography, adaptation and interactions with associated organisms. Moreover, genomic studies are now finally also entering the world of conservation and forest management, for example by measuring the value or cost of interspecific hybridization and introgression, assessing the vulnerability of species and populations to future change, or accurately delineating evolutionary significant units. The newly launched conference series of EvolTree will hopefully play a key role in the exchange and synthesis of such important investigations.
Numerical evaluation of face masks for prevention of COVID-19 airborne transmission
Authors: Liu Jiaxing , Hao Ming , Chen Shulei , Yang Yang , Li Jian , Mei Qi , Bian Xin , Liu Kun 
Published: February 2022

AbstractThe COVID-19 pandemic has forced governments around the globe to apply various preventive measures for public health. One of the most effective measures is wearing face masks, which plays a vital role in blocking the transmission of droplets and aerosols. To understand the protective mechanism of face masks, especially in indoor environments, we apply a computational fluid dynamics technique to predict the lifetime of cough droplets. Therefore, we can assess the exposure risk in a ventilated room where an infected individual wears a face mask or not. We focus on the dynamic evaporation and diffusion of droplets in a human-cough process, which is a major cause for the spread of the virus. We find that wearing a face mask can effectively reduce the total mass and Sauter mean diameter of the residual droplets after a single cough. The mass concentration of virus-carrying droplets in the ventilated room decreases by 201, 43,786, and 307,060 times, corresponding to wearing cotton face masks, surgical face masks, and N95 face masks, respectively. However, the maximum travel distance of 80% droplets is insensitive to wearing a face mask or not. Therefore, the residual droplets are widely distributed due to the influence of indoor airflow. Furthermore, we study aerosol exposure risks in different areas of the room and find that high concentrations of aerosols occur in the streamline through an infected individual, especially next to the individual within 1.5 m. This strongly suggests a social distance despite the fact that the majority of droplets are filtered by face masks. This study explains the impact of face masks and airflow on indoor exposure risks and further inspires potential measures for public health, for example, no individuals should sit near the air supply opening.