bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silence and the city: an examination of the power of architectural form
Authors: Lyons Frank 
Published: October 2022

The article suggests that the misuse of architectural form is the major threat to our cities. Form has power and form used mindlessly has indiscriminate consequences for the urban environment and its citizens.To explore this ‘silent’ power of form, the article takes Louis Kahn’s lecture on ‘Silence and Light’ as its opening text. Kahn‘s distinction between the ‘measurable’ and ‘unmeasurable’ dimensions of architecture is compared to similar distinctions made by Kant, and extended by Schopenhauer at the turn of the nineteenth century. We learn that it is the ‘unmeasurable’ aspect of reality that gives form its power and in the second part of the article, using detailed analyses of Frank Lloyd Wright’s work, we are able to explain how the ‘unmeasurable’ is revealed within the ‘measurable’ and how such carefully balanced use of form can make a significant contribution to the health of our cities.
Effects of early-life voluntary exercise and fructose on adult activity levels, body composition, aerobic capacity, and organ masses in mice bred for high voluntary wheel-running behavior
Authors: Cadney Marcell D. , Albuquerque Ralph L. , Schwartz Nicole E. , McNamara Monica P. , Castro Alberto A. , Schmill Margaret P. , Hillis David A. , Garland Theodore 
Published: October 2022

AbstractFructose (C6H12O6) is acutely obesogenic and is a risk factor for hypertension, cardiovascular disease, and nonalcoholic fatty liver disease. However, the possible long-lasting effects of early-life fructose consumption have not been studied. We tested for effects of early-life fructose and/or wheel access (voluntary exercise) in a line of selectively bred High Runner (HR) mice and a non-selected Control (C) line. Exposures began at weaning and continued for 3 weeks to sexual maturity, followed by a 23-week "washout" period (equivalent to ∼17 human years). Fructose increased total caloric intake, body mass, and body fat during juvenile exposure, but had no effect on juvenile wheel running and no important lasting effects on adult physical activity or body weight/composition. Interestingly, adult maximal aerobic capacity (VO2max) was reduced in mice that had early-life fructose and wheel access. Consistent with previous studies, early-life exercise promoted adult wheel running. In a 3-way interaction, C mice that had early-life fructose and no wheel access gained body mass in response to 2 weeks of adult wheel access, while all other groups lost mass. Overall, we found some long-lasting positive effects of early-life exercise, but minimal effects of early-life fructose, regardless of the mouse line.
The effect of a movable headrest in shoulder assist device for overhead work
Authors: Ishii Chiharu , Hirasawa Kanta 
Published: October 2022

Abstract
Recently, many kinds of shoulder-support exoskeletons have been developed and some of them are commercially available. However, to the best of our knowledge, shoulder-support exoskeletons that have neck-support mechanism have not been found. During the overhead work, physical strain is added to not only upper limb and shoulder but also neck of workers since the workers work keeping their face raised. Therefore, in this study, to reduce the physical strain on the neck during the overhead work, a movable headrest that can be attached to the shoulder assist device was developed, which has reclining and slide functions of a head. The main purpose of this article was to evaluate usefulness of the proposed movable headrest. To this end, measurements of electromyogram were carried out under simulating an overhead work activity, and the reduction effect for physical strain of the neck was compared among three types of headrests: (a) slide-type headrest which can slide the head backward and forward, (b) reclining-type headrest which can recline the head, and (c) reclining and slide-type headrest which can recline and slide the head. In addition, usefulness of the shoulder assist device with the proposed headrest was evaluated for a realistic overhead work activity through measurements of muscular stiffness of neck and shoulder. The experimental results showed that the existence of the headrest in the shoulder assist device is effective to reduce the physical strain to the workers, and that (c) reclining and slide-type headrest is the most effective among these three types of headrests.
An Imaging Evidence of the East Wall Structuring of Eastward Drifting Depletions Observed Near the EIA Crest in India
Authors: Padincharapad Saranya , Parihar Navin , Taori Alok , Sripathi Samireddipalle 
Published: October 2022

AbstractStructuring on the west (east) wall of eastward (westward) drifting airglow depletion under quiet (storm) time is common. Here, we report for the first time the rare occurrence of the east wall structuring of an eastward drifting depletion near the crest of equatorial ionization anomaly (EIA) in India on 16 April 2012 under quiet geomagnetic conditions. We observed a linear depletion having a westward tilt of ∼25° and eastward drift speed of ∼129 m/s in the beginning. First prominent structuring occurred on its west wall that later swiftly surged poleward within next 6–12 min and bifurcated, that is, behaved like a secondary depletion growing on the primary one. Second west wall structuring then occurred but had considerably subdued growth. Meanwhile, main depletion bent slightly eastward above its branching node, and two structuring appeared on the east wall in succession. Secondary depletion then slightly contracted equatorward, and structuring emerged from its east wall, too, that later stretched eastward, got linked with main depletion and formed grid mesh shaped feature. Second structuring on the west wall started fading; while, those on the east wall swiftly evolved, surged poleward and gained prominence. Also, their westward tilt decreased. During the occurrence of these events, gravity waves (GWs) and the retreat of EIA were active overhead. Current study serves as first imaging evidence of Zalesak et al. (1982, https://doi.org/10.1029/JA087iA01p00151) simulations that the east wall of a westward tilted depletion can become unstable and host secondary instabilities. Possibly these structuring were excited by GWs via Rayleigh‐Taylor instability.
Blood levels of T-Cell Receptor Excision Circles (TRECs) provide an index of exposure to traumatic stress in mice and humans
Authors: McCullough Kenneth M. , Katrinli Seyma , Hartmann Jakob , Lori Adriana , Klengel Claudia , Missig Galen , Klengel Torsten , Langford Nicole A. , Newman Emily L. , Anderson Kasey J. , Smith Alicia K. , Carroll F. Ivy , Ressler Kerry J. , Carlezon William A. 
Published: October 2022

AbstractExposure to stress triggers biological changes throughout the body. Accumulating evidence indicates that alterations in immune system function are associated with the development of stress-associated illnesses such as major depressive disorder and post-traumatic stress disorder, increasing interest in identifying immune markers that provide insight into mental health. Recombination events during T-cell receptor rearrangement and T-cell maturation in the thymus produce circular DNA fragments called T-cell receptor excision circles (TRECs) that can be utilized as indicators of thymic function and numbers of newly emigrating T-cells. Given data suggesting that stress affects thymus function, we examined whether blood levels of TRECs might serve as a quantitative peripheral index of cumulative stress exposure and its physiological correlates. We hypothesized that chronic stress exposure would compromise thymus function and produce corresponding decreases in levels of TRECs. In male mice, exposure to chronic social defeat stress (CSDS) produced thymic involution, adrenal hypertrophy, and decreased levels of TRECs in blood. Extending these studies to humans revealed robust inverse correlations between levels of circulating TRECs and childhood emotional and physical abuse. Cell-type specific analyses also revealed associations between TREC levels and blood cell composition, as well as cell-type specific methylation changes in CD4T + and CD8T + cells. Additionally, TREC levels correlated with epigenetic age acceleration, a common biomarker of stress exposure. Our findings demonstrate alignment between findings in mice and humans and suggest that blood-borne TRECs are a translationally-relevant biomarker that correlates with, and provides insight into, the cumulative physiological and immune-related impacts of stress exposure in mammals.
Impact of high-access exercise prior to and during early adolescence on later vulnerability to opioid use and relapse in male rats
Authors: Lynch Wendy J. , Bakhti-Suroosh Anousheh , Abel Jean M. 
Published: October 2022

AbstractMiddle- and high-school athletes participating in certain team sports are at greater risk of opioid misuse and addiction than those who do not. While this risk is thought to be due to increased access to opioids, in this study we explored the possibility that the sensitizing effects of discontinued high-intensity exercise may also contribute. Specifically, using male rat models with fentanyl, we tested the hypothesis that high-access exercise (24 h/day access to a running wheel) during pre/early adolescence (two weeks, postnatal-day 24–37) would enhance vulnerability to opioid use and relapse during late adolescence/adulthood. Rats with a history of high-access exercise showed stronger fentanyl-associated lever discrimination during acquisition, greater motivation to obtain infusions of fentanyl following acquisition, and had an enhanced sensitivity to the reinstating effects of fentanyl-associated cues following extended (24 h/day), intermittent-access self-administration and protracted abstinence (14 days) compared to sedentary controls. In contrast, sedentary rats had greater overall responding (active- and inactive-lever) during acquisition and greater non-specific (inactive-lever) responding during extended-access self-administration. Molecular markers associated with opioid seeking/relapse were also differentially expressed in the nucleus accumbens core of rats with versus without a history of high-access exercise following relapse testing (e.g., Bdnf-IV and Drd2 expression). Together, these findings demonstrate that high-access exercise prior to and throughout early-adolescence enhances vulnerability to the reinforcing and cue-induced reinstating effects of opioids during later adolescence/adulthood. Thus, it is possible that the discontinuation of high intensity exercise contributes to the enhanced vulnerability observed in middle- and high-school athletes.
Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1
Authors: Kholmanskikh Stanislav , Singh Shawn , Ross M. Elizabeth 
Published: October 2022

AbstractRegulation of Rho GTPases remains a topic of active investigation as they are essential participants in cell biology and the pathophysiology of many human diseases. Non-degrading ubiquitination (NDU) is a critical regulator of the Ras superfamily, but its relevance to Rho proteins remains unknown. We show that RhoC, but not RhoA, is a target of NDU by E3 ubiquitin ligase, LNX1. Furthermore, LNX1 ubiquitination of RhoC is negatively regulated by LIS1 (aka, PAFAH1B1). Despite multiple reports of functional interaction between LIS1 and activity of Rho proteins, a robust mechanism linking the two has been lacking. Here, LIS1 inhibition of LNX1 effects on RhoGDI-RhoC interaction provides a molecular mechanism underpinning the enhanced activity of Rho proteins observed upon reduction in LIS1 protein levels. Since LNX1 and RhoC are only found in vertebrates, the LIS1-LNX1-RhoC module represents an evolutionarily acquired function of the highly conserved LIS1. While these nearly identical proteins have several distinct RhoA and RhoC downstream effectors, our data provide a rare example of Rho-isoform specific, upstream regulation that opens new therapeutic opportunities.
Ultrasound-assessed diaphragm dysfunction predicts clinical outcomes in hemodialysis patients
Authors: Zheng Jing , Yin Qing , Wang Shi-yuan , Wang Ying-Yan , Xiao Jing-jie , Tang Tao-tao , Ni Wei-jie , Ren Li-qun , Liu Hong , Zhang Xiao-liang , Liu Bi-Cheng , Wang Bin 
Published: October 2022

AbstractSkeletal muscle atrophy is prevalent and remarkably increases the risk of cardiovascular (CV) events and mortality in hemodialysis (HD) patients. However, whether diaphragm dysfunction predicts clinical outcomes in HD patients is unknown. This was a prospective cohort study of 103 HD patients. After assessment of diaphragm function by ultrasonography and collection of other baseline data, a 36-month follow-up was then initiated. Participants were divided into diaphragm dysfunction (DD+) group and normal diaphragm function (DD−) group, according to cutoff value of thickening ratio (i.e. the change ratio of diaphragm thickness) at force respiration. The primary endpoint was the first nonfatal CV event or all-cause mortality. A secondary endpoint was less serious CV events (LSCEs, a composite of heart failure readmission, cardiac arrhythmia or myocardial ischemia needed pharmacological intervention in hospital). 98 patients were eligible to analysis and 57 (58.16%) were men. 28 of 44 patients(63.64%) in DD+ group and 23 of 54 patients (42.59%) in DD− group had at least one nonfatal CV event or death (p = 0.038). Compared to DD− group, DD+ group had significantly higher incidence of LSCEs (21 vs.14, p = 0.025) and shorter survival time (22.02 ± 12.98 months vs. 26.74 ± 12.59 months, p = 0.046). Kaplan–Meier analysis revealed significantly higher risks of primary endpoint (p = 0.039), and LSCEs (p = 0.040) in DD+ group. Multivariate hazard analysis showed that DD+ group had significantly higher risk of primary endpoint [hazard ratio (HR) 1.59; 95% confident interval (CI) 1.54–1.63], and LSCEs (HR 1.47; 95%CI 1.40–1.55). Ultrasound-assessed diaphragm dysfunction predicts clinical outcomes in HD patients.Trial registration: This study was registered with Chinese Clinical Trials Registry (www.chictr.org.cn) as ChiCTR1800016500 on Jun 05, 2018.
Case growth analysis to inform local response to COVID-19 epidemic in a diverse U.S community
Authors: de Oliveira Otto Marcia C. , Brito Frances A. , Tark Ji Yun , Bakota Eric , Yamal Jose-Miguel , Marko Dritana , Sharma Shreela V. , Brown Michael R. , Appana Savitri N. , Rector Alison M. , Linder Stephen H. , Kiger Jennifer , Tseng Karen C. , Morrison Alanna C. , Boerwinkle Eric 
Published: October 2022

AbstractEarly detection of new outbreak waves is critical for effective and sustained response to the COVID-19 pandemic. We conducted a growth rate analysis using local community and inpatient records from seven hospital systems to characterize distinct phases in SARS-CoV-2 outbreak waves in the Greater Houston area. We determined the transition times from rapid spread of infection in the community to surge in the number of inpatients in local hospitals. We identified 193,237 residents who tested positive for SARS-CoV-2 via molecular testing from April 8, 2020 to June 30, 2021, and 30,031 residents admitted within local healthcare institutions with a positive SARS-CoV-2 test, including emergency cases. We detected two distinct COVID-19 waves: May 12, 2020–September 6, 2020 and September 27, 2020–May 15, 2021; each encompassed four growth phases: lagging, exponential/rapid growth, deceleration, and stationary/linear. Our findings showed that, during early stages of the pandemic, the surge in the number of daily cases in the community preceded that of inpatients admitted to local hospitals by 12–36 days. Rapid decline in hospitalized cases was an early indicator of transition to deceleration in the community. Our real-time analysis informed local pandemic response in one of the largest U.S. metropolitan areas, providing an operationalized framework to support robust real-world surveillance for outbreak preparedness.
Design and performance study of grease spool-less relief valve
Authors: Gong Guoqing , Wang Youmin , Zhou Bin 
Published: October 2022

AbstractThe high resistance characteristic of the grease delivery process makes the centralized lubrication system easy to cause pipeline blockage during the grease supply process. The main objective of the present article is to design a non-spool relief valve device based on the round pipe. The plug shape characteristics of the grease flow in the tube are established by combining the hydrodynamic equation and the grease rheological model. The mathematical model, whose relationship between velocity and flow is derived, is established with the core pipe of the grease spool-less relief valve of flow resistance, so the factors affecting grease pipe flow are obtained. The numerical simulation method is used to simulate the lipid overflow process of the simplified model with different influence parameters. Tecplot 360 EX 2015 R1 is used as a post-processing software to derive velocity and pressure clouds for grease flow in a circular tube, to investigate the factors influencing the relief pressure and relief capacity of the relief valve, to derive general rules for grease relief pressure, grease relief capacity and grease flow pattern distribution, and to establish an evaluation model for the relief pressure and relief capacity of the relief valve. The performance research test platform of the grease spool-less relief valve is built, and NLGI1 lithium grease is selected to carry out the experimental study on the performance of the grease relief valve under different influence parameters. The safety, stability, and feasibility of the overflow valve working with the pumping system are verified.
A one-pot rotational DC-bipolar approach for fabricating artistic metallic carpets
Authors: Gholami Fereshte , Shamsipur Mojtaba , Pashabadi Afshin 
Published: October 2022

AbstractThis is a brief report on the fabrication of concentric multi-element metallic carpets through a one-pot rotational bipolar electro-engineering procedure. A suspended piece of nickel foam as a bipolar electrode (BPE) is rotated in an aqueous solution containing a ternary mixture of metal ions when sufficient DC potential is applied to driving electrodes. The customizable tools of this art are potential gradient, rotation, and concentration/kinetic polarizations. Creating the multi-element radial gradient is typically tested in a one-pot artistic jewelry electroplating.
Temperature and salinity preferences of endangered Delta Smelt (Hypomesus transpacificus, Actinopterygii, Osmeridae)
Authors: Hung Tien-Chieh , Hammock Bruce G. , Sandford Marade , Stillway Marie , Park Michael , Lindberg Joan C. , Teh Swee J. 
Published: October 2022

AbstractTemperature and salinity often define the distributions of aquatic organisms. This is at least partially true for Delta Smelt, an imperiled species endemic to the upper San Francisco Estuary. While much is known about the tolerances and distribution of Delta Smelt in relation to these parameters, little is known regarding the temperature and salinity preferences of the species. Therefore, the temperature and salinity preferences of sub-adult Delta Smelt were investigated across a wide range of thermal (8–28 °C) and salinity (0–23 ppt) conditions. Replicates of ten fish were allowed to swim between two circular chambers with different temperature or salinity, and the distribution of fish between the chambers was recorded. We found that Delta Smelt showed no temperature preference below 15 °C, a modest aversion to the warmer tank from 15 to 28 °C, and a strong aversion to the warmer tank with elevated mortality at temperatures above 28 °C. Delta Smelt also preferred lower salinities, and this preference became more pronounced as salinity increased toward 23 ppt. These results indicate that Delta Smelt can tolerate high temperatures and salinities for a short time, and that their preferences for lower temperature and salinity strengthens as these variables increase.
Allostatic load predicts racial disparities in intracerebral hemorrhage cognitive outcomes
Authors: Harris Jennifer , Boehme Amelia , Chan Luisa , Moats Harmon , Dugue Rachelle , Izeogu Chigozirim , Pavol Marykay A. , Naqvi Imama A. , Williams Olajide , Marshall Randolph S. 
Published: October 2022

AbstractA large portion of stroke disparities remains unexplained, even after adjusting for demographic, comorbidity, and health care access variables. There is a critical need to close this knowledge gap by investigating novel factors that may contribute to stroke disparities. Allostatic load (AL) is the lifetime adverse physiologic impact of needing to adjust to socially structured stressors such as racism. AL has been shown to increase health vulnerability and worsen outcomes in marginalized populations. We sought to assess the differential impact of AL on cognitive outcomes post intracerebral hemorrhage (ICH) across race-ethnicity. The Intracerebral Hemorrhage Outcomes Project (ICHOP) prospectively collected data from patients presenting to Columbia Medical Center with ICH from 3/2009 to 5/2016. Data included demographics, stroke scores, labs, complications, neuroimaging, medical history, and discharge data. Five markers of AL (HbA1c, WBC, SBP, HR, ALB) were obtained. An AL score was generated by summing the elements in each patient that fell outside normal ranges, with AL score ranging 0–5. A linear regression model, adjusted for stroke severity and ICH volumes, was used to evaluate the relationship between AL and Modified Telephone Interview for Cognitive Status (TICS-m) at discharge, stratified by race-ethnicity. Among 248 white, 195 black, and 261 Hispanic ICH patients, neither mean AL nor mean TICS differed by race/ethnicity (p = 0.51, p = 0.79 respectively). In the overall cohort AL did not predict TICS at discharge (Beta -1.0, SE 1.1, p = 0.353). In Whites (beta 1.18, SE 2.5, p = 0.646) and Hispanics (beta -0.95, SE 1.6, p = 0.552) AL was not associated with TICS at discharge. In Black patients, higher AL was associated with a decrease in TICS at discharge (beta -3.2, SE 1.5, p = 0.049). AL is an important determinant of post ICH outcomes for certain minority populations. AL may explain some of the unexplained health disparities in stroke populations.
Avalanche photodiodes with multiple multiplication layers for coherent detection
Authors: Ahmad Zohauddin , Wang Po-Shun , Naseem  , Huang Yu-Cyuan , Chang Yan-Chieh , Chang You-Chia , Lee Yi-Shan , Shi Jin-Wei 
Published: October 2022

AbstractWe demonstrate a novel avalanche photodiode (APD) design which fundamentally relaxes the trade-off between responsivity and saturation-current performance at receiver end in coherent system. Our triple In0.52Al0.48As based multiplication (M-) layers with a stepped electric (E-) field inside has more pronounced avalanche process with significantly less effective critical-field than the dual M-layer. Reduced E-field in active M-layers ensures stronger E-field allocation to the thick absorption-layer with a smaller breakdown voltage (Vbr) resulting in less serious space-charge screening effect, less device heating at high output photocurrent. Compared to the dual M-layer reference sample, the demonstrated APD exhibits lower punch-through (− 9 vs. − 24 V)/breakdown voltages (− 43 vs. − 51 V), higher responsivity (19.6 vs. 13.5 A/W), higher maximum gain (230 vs. 130), and higher 1-dB saturation-current (> 5.6 vs. 2.5 mA) under 0.95 Vbr operation. Extremely high saturation-current (> 14.6 mA), high responsivity (7.3 A/W), and decent O-E bandwidth (1.4 GHz) can be simultaneously achieved using the demonstrated APD with a 200 µm active window diameter. In coherent FMCW LiDAR test bed, this novel APD exhibits a larger signal-to-noise ratio and high-quality 3-D images than the reference dual M-layer and high-performance commercial p-i-n PD modules, while requiring significantly less optical local-oscillator (LO) power (0.5 vs 4 mW).