bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testing Spacetime Orientability
Authors: Bielińska Marta , Read James 
Published: November 2022

AbstractHistorically, a great deal of attention has been addressed to the question of what it would take to test experimentally the metrical structure of spacetime. Arguably, however, consideration of this question has been at the expense of comparable investigations into what it would take to test other structural features of spacetime. In this article, we critique and expand substantially upon an article by Hadley (Hadley in Class Quantum Gravity, 19:4565–4571, 2002), which constitutes one of the best-known paper-length studies of what it would take to test the orientability of spacetime. In so doing, we seek to clarify a number of matters which remain unclear in the wake of Hadley’s article, thereby allowing the literature on this topic to progress. More positively, we also present, compare, and evaluate a number of other potential approaches to testing the orientability of spacetime which have arisen in the recent physics literature.
Eco-friendly Synthesis of Carbon Quantum Dots as an Effective Adsorbent
Authors: Tohamy Hebat‑Allah S. , El‑Sakhawy Mohamed , Kamel Samir 
Published: November 2022

AbstractFluorescent carbon quantum dots (CQDs) were prepared by an economical, green, and single-step procedure with the assistance of microwave heating of urea with bagasse (SCB), cellulose (C), or carboxymethyl cellulose (CMC). The prepared CQDs were characterized using a series of spectroscopic techniques, and they had petite size, intense absorption in the UV, and excitation wavelength-dependent fluorescence. The prepared CQDs were used for Pb(II) adsorption from an aqueous solution. The removal efficiency percentages (R %) were 99.16, 96.36, and 98.48% for QCMC, QC, and QSCB, respectively. The findings validated the efficiency of CQDs synthesized from CMC, cellulose, and SCB as excellent materials for further utilization in the environmental fields of wastewater pollution detection, adsorption, and chemical sensing applications. The kinetics and isotherms studied found that all CQDs isotherms fit well with the Langmuir model than Freundlich and Temkin models. According to R2, the pseudo-second-order fits the adsorption of QCMC, while the first-order one fits with QC and QSCB.
Single-Molecule Characterization of Cy3.5 -Cy5.5 Dye Pair for FRET Studies of Nucleic Acids and Nucleosomes
Authors: Ghoneim Mohamed , Musselman Catherine A. 
Published: November 2022

AbstractSingle molecule FRET (Forster resonance energy transfer) is very powerful method for studying biomolecular binding dynamics and conformational transitions. Only a few donor - acceptor dye pairs have been characterized for use in single-molecule FRET (smFRET) studies. Hence, introducing and characterizing additional FRET dye pairs is important in order to widen the scope of applications of single-molecule FRET in biomolecular studies. Here we characterize the properties of the Cy3.5 and Cy5.5 dye pair under FRET at the single-molecule level using naked double-stranded DNA (dsDNA) and the nucleosome. We show that this pair of dyes is photostable for ~ 5 min under continuous illumination. We also report Cy3.5-Cy5.5 FRET proximity dependence and stability in the presence of several biochemical buffers and photoprotective reagents in the context of double-stranded DNA. Finally, we demonstrate compatibility of the Cy3.5-Cy5.5 pair for smFRET in vitro studies of nucleosomes.
Synergistic effect of cerium and structure directing agent on drug release behavior and kinetics
Authors: Farag M. M. , Al-Rashidy Z. M. 
Published: November 2022

AbstractThis work was mainly aimed at the study of the dual effect of cerium and structure directing agent template concentration, on vancomycin release profiles and kinetics from Ce-substituted mesoporous bioactive glasses (MBGs). MBG based on (20-x) B2O3 - 55 SiO2 – 20 CaO – 5 P2O5 – x Ce2O (x = 0, 1 and 3 mol %) was synthesized by the evaporation-induced self-assembly process using two molar ratios (0.01 and 0.02 molar ratio) of nonionic block copolymer Pluronic® 123 (P123) surfactant. The TGA-DTA, FTIR, and textural features analyses were carried out for the glasses. Moreover, the in vitro bone-forming activity and degradation analysis were tested using simulated body fluid (SBF). The drug loading capacity, drug release profile, and kinetics (using different kinetic models such as first order, Higuchi, Hixson-Crowell, and Baker-Lonsdale models) were determined using vancomycin as a drug model. The results showed that the isotherms of all MBGs fit with type IV isotherms, and the surface area of MBGs synthesized by 0.02 M template was higher than that prepared by 0.01 M, where it ranged from 174.05 m2.g−1 to 256.73 m2.g−1. The pore size diameter was decreased as cerium content increased in all MBGs (decreased from 5.44 to 3.54 nm). Moreover, the MBGs induced the formation of a bone-like apatite layer, and their biodegradation properties can be tailored by controlling glass composition. Furthermore, Ce-free MBGs showed the lowest drug adsorption and the highest drug release percentage. The drug release kinetic was best fitted with Higuchi and Baker-Lonsdale models which denoted that the mechanism of drug release from MBGs was a diffusion release from spherical particles. In conclusion, vancomycin release was controlled by the glass composition. Meanwhile, the MBGs synthesized in this study are proposed to be applied for bone regeneration, bone cancer treatment, and reducing the bacterial activity around the tumor site.
Racial Capitalism and the Dialectics of Development: Exposing the Limits and Lies of International Economic Law
Authors: Attar Mohsen al , Smith Claire 
Published: November 2022

AbstractInternational economic law is peculiar. It claims universal character, yet eschews engagement with many, if not all, the racialised features of the global political economy. Its scholars mostly ignore imperialism, colonialism, and capitalism; they exclude slavery, predation, and racism altogether. In the following article, we draw upon Walter Rodney’s dialectics of development to offer a racial capitalist critique of international economic law. The disciplinary boundaries and operative logic normalised by its denizens corral us in a white, Eurocentric episteme. Ahistoricism, decontextualisation, and externalisation are three epistemic devices at the forefront of the exclusionary discourse of IEL. In this space, the histories and epistemologies of Black peoples are ghettoised, treated as alien to the framework. After identifying this bias, we use the Black Radical Tradition to evaluate IEL’s amenability to the racial capitalism critique.
From Sagen to Henriques: Legal Challenges to Olympic Event Selection Decisions and the Role of the Court of Arbitration for Sport
Authors: Mazzucco Marcus , Findlay Hilary 
Published: November 2022

AbstractThe interests of athletes are a fundamental aspect of the Olympic Movement. Yet, athletes face jurisdictional barriers when attempting to advance their interests and challenge the International Olympic Committee (IOC)’s exercise of authority over the Olympic Movement, including the IOC’s decisions regarding which sport events are included in the Olympic Games. Previous attempts to challenge the IOC’s selection of sport events for the Olympic Games have been unsuccessful in national courts, as seen in the case of Sagen v. Vancouver Organizing Committee for the 2010 Olympic and Paralympic Winter Games (“Sagen”) involving women’s ski jumping. Following the outcome in Sagen, academics theorized that athletes might have better success challenging Olympic event selection decisions at the Court of Arbitration for Sport (CAS), as CAS has several jurisdictional advantages over national courts. A recent CAS decision in Henriques v. IOC (“Henriques”), involving the exclusion of women’s 50 km race walking from the 2020 Olympic Games, casts doubt on this approach as CAS dismissed the application due to the lack of an arbitration agreement between the appellants and the IOC. However, the outcome in Henriques should not deter athletes from using CAS to challenge the IOC’s Olympic event selection decisions in future cases. It is arguable that the CAS panel’s reasoning in Henriques did not properly consider how the arbitration clause in the Olympic Charter could form the basis of an arbitration agreement between the appellants and the IOC under Swiss law. Additionally, the CAS panel’s decision in Henriques can be used to inform legal strategies in subsequent disputes to ensure that CAS is able to hold the IOC accountable for Olympic event selection decisions that are discriminatory or otherwise unlawful.
Identification of eIF6 as a prognostic factor that drives tumor progression and predicts arsenic trioxide efficacy in lung adenocarcinoma
Authors: Shen Yan , Zhang Ruihong , Li Xiangrui 
Published: November 2022

Abstract
Background
Lung cancer is the leading cause of cancer-related mortality worldwide. Dysregulation of mRNA translation can contribute to the development and progression of cancer whilst also having an impact on the prognosis of different types of malignancies. Eukaryotic translation initiation factors (eIFs) have been reported to serve a key role in the initiation of mRNA translation. However, little was known about the association between eIF6 and lung adenocarcinoma (LUAD) progression. We aimed to elucidate the roles of eIF6 in LUAD tumorigenesis.

Methods
Bioinformatic analysis was conducted to assess the clinical significance of eIF6 in LUAD. CCK-8, colony formation assays were used to evaluate the biological roles of eIF6. The subcutaneous model was used to assess the in vivo roles of eIF6.

Results
In the present study, it was found that eIF6 expression was significantly higher in LUAD samples compared with that in normal lung tissues. Higher expression levels of eIF6 were found to be associated with more advanced clinical stages of LUAD and poorer prognoses in patients with LUAD. Subsequently, overexpression of eIF6 was demonstrated to promote LUAD cell proliferation, migration and invasion, which are features of metastasis, in vitro. By contrast, inhibition of eIF6 induced cell cycle arrest and apoptosis in LUAD cells. Further bioinformatics analysis and experimental assays revealed that eIF6 expression positively correlated with the mRNA expression of stemness-associated genes in LUAD cells. Targeting eIF6 suppressed the sphere formation capacity of LUAD cells. In addition, data from the subcutaneous xenograft model in vivo also suggested that eIF6 deficiency could significantly delay tumor growth and improve the prognosis of mice. Targeting eIF6 rendered LUAD cells sensitive to arsenic trioxide treatment.

Conclusion
The present study suggest that eIF6 can serve as a prognostic biomarker and a potential therapeutic target for patients with LUAD.
Pathways to policy integration: a subsystem approach
Authors: Cejudo Guillermo M. , Trein Philipp 
Published: November 2022

AbstractResearchers in public policy and public administration agree that policy integration is a process. Nevertheless, scholars have given limited attention to political aspects that facilitate or impede integration. This paper aims at filling that gap, by looking at how different theories of the policy process can help in explaining the process of policy integration as shaped by policy subsystems. By building on insights from theories of the policy process, we develop pathways regarding adoption and implementation in policy integration that account for the politicization and the role of actors and subsystems in the policy process. Our main argument is that policy integration is in permanent political tension with the sectoral logic of policymaking, which predominantly happens between actors in subsystems. Policy integration is, thus, not a single moment when those tensions are solved once and for all, but a political process that requires deliberate efforts to overcome the pull toward sector-specific problem definition, policymaking, implementation, and evaluation.
Regulatory Artifacts: Prescribing, Constituting, Steering
Authors: Lorini Giuseppe , Moroni Stefano , Loddo Olimpia Giuliana 
Published: November 2022

AbstractGenerally, when thinking of artifacts, one imagines “technical artifacts”. Technical artifacts are those artifacts that perform a mere causal function. Their purpose is to instrumentally help and support an action, not to change behaviour. However, technical artifacts do not exhaust the set of artifacts. Alongside technical artifacts there are also artifacts that we can call “cognitive artifacts”. Cognitive artifacts are all those artifacts that operate upon information in order to improve human cognitive performances. Artifacts of a further, different kind are what we may call “regulatory artifacts”; that is, material artifacts devised and made to regulate behaviour. Consider a roundabout, a traffic light or a speed bump. These artifacts do not make us stronger, faster, or more intelligent. They are placed on the road surface to regulate traffic. This article investigates artifacts of this third kind and, especially, the functions that they perform.
The Shadow of Affectivity Inside the ‘Is/Ought’ Debate’: Siniscalchi, Fuller, Manderson and Vico’s Ghosts in the Legal Machine
Authors: Heritier Paolo 
Published: November 2022

AbstractThe article reconstructs the is/ought debate in legal theory through a phenomenological reading of the concept of normality. An analysis of Siniscalchi, Fuller and Manderson looks at the issue from the perspective of law and literature, and then applies Giambattista Vico’s rhetorical methodology within the contemporary debate. The question: “is Hume’s law really visible within Hume’s thought?” also paradoxically poses the figure of phantoms and fictions at the heart of the current theoretical debate on law. A history of the phantom placed at the centre of the history of Western institutions still remains to be written, but a comparison of very diverse and incongrous approaches such as the extended order of Hayek, the dogmatic anthropology of Legendre, the eunomics of Fuller and the new science of Vico shows how the mystery of consciousness and the mystery of institutions are inextricably entwined. It is impossible at the moment to draw a coherent doctrine from these conflicting perspectives, but their convocation is sufficient to demonstrate how the theory of law is always suspended between the unknown and the human attempt to inhabit it, moving us toward an affective turn that has yet to be fully conceived in the theory of law, following the iconic turn. The anthropological primacy of fictio and the aesthetic-legal dimension in the constitution of language is not that of a logic and separation from the body and meaning, but the exact inverse, even in the unavoidable constant tension between the two poles: logic is born through the gesture of the body that precedes it, as myth precedes the foundation of the State; the origin of the concept is affective, as Hume, and perhaps Vico himself, would have passionately affirmed.
Exploring the knowledge structure of entrepreneurship education and entrepreneurial intention
Authors: Nájera-Sánchez Juan-José , Pérez-Pérez Cristina , González-Torres Thais 
Published: November 2022

AbstractThe literature has widely recognized entrepreneurial intention as the best variable for predicting entrepreneurial behaviour. Entrepreneurial education represents a possible way to foster that intention. The interest in stimulating entrepreneurship activity has led to a growth in the number and disparity of publications that analyse the entrepreneurship education-entrepreneurial intention. This paper carries out a bibliometric analysis using bibliographic coupling to map the field’s knowledge structure. This study’s results contribute to the field complementing the previous literature reviews by addressing and verifying the development of the research lines proposed by them. Our approach is methodologically original, analysing the clusters in the network, including a characterization of each of them and the most significant and representative cited references for each group. Among the main conclusions, we find that although the theoretical base of most of the studies is found in classic theories, some alternative approaches dealing with emotional variables, mentality approaches, or psychological traits are more frequent in recent years and can play an important role in the future of the field, as the factors related to the intention-to-behaviour transition are a central focus of current research. Additionally, the contradictory results in past studies have focused the new developments around the influence of contextual factors that constitute an essential new direction for this research.
Female chatbots are helpful, male chatbots are competent?
Authors: Bastiansen Mathilde H. A. , Kroon Anne C. , Araujo Theo 
Published: November 2022

AbstractChatbots have in recent years increasingly been used by organizations to interact with their customers. Interestingly, most of these chatbots are gendered as female, displaying stereotypical notions in their avatars, profile pictures and language. Considering the harmful effects associated with gender-based stereotyping at a societal level—and in particular the detrimental effects to women—it is crucial to understand the effects of such stereotyping when transferred and perpetuated by chatbots. The current study draws on the Stereotype Content Model (SCM) and explores how the warmth (high vs. low) of a chatbot’s language and the chatbot’s assigned gender elicit stereotypes that affect the perceived trust, helpfulness, and competence of the chatbot. In doing so, this study shows how established stereotype theory can be used as a framework for human-machine communication research. Moreover, its results can serve as a foundation to explore ways of mitigating the perpetuation of stereotyping and bring forward a broader discussion on ethical considerations for human-machine communication.
Single-cell RNA-Seq analysis of diabetic wound macrophages in STZ-induced mice
Authors: Ma Jiaxu , Song Ru , Liu Chunyan , Cao Guoqi , Zhang Guang , Wu Zhenjie , Zhang Huayu , Sun Rui , Chen Aoyu , Wang Yibing , Yin Siyuan 
Published: November 2022

AbstractThe crucial role of macrophages in the healing of chronic diabetic wounds is widely known, but previous in vitro classification and marker genes of macrophages may not be fully applicable to cells in the microenvironment of chronic wounds. The heterogeneity of macrophages was studied and classified at the single-cell level in a chronic wound model. We performed single-cell sequencing of CD45 + immune cells within the wound edge and obtained 17 clusters of cells, including 4 clusters of macrophages. One of these clusters is a previously undescribed population of macrophages possessing osteoclast gene expression, for which analysis of differential genes revealed possible functions. We also analysed the differences in gene expression between groups of macrophages in the control and diabetic wound groups at different sampling times. We described the differentiation profile of mononuclear macrophages, which has provided an important reference for the study of immune-related mechanisms in diabetic chronic wounds.
Graphical Abstract
From Spatial Forms to Perception: Reassessing Georg Simmel’s Theory of Space
Authors: Berger Viktor 
Published: November 2022

AbstractAmong the founders of sociology, it was Georg Simmel who provided the most thorough analysis and theory of space. This paper aims to reconstruct Simmel’s spatial theory and his observations of spatial relations. The German sociologist engaged with spatiality in a threefold way. First, he tried to provide a systematic social theory of space; second, analyzing spatial relations was important for his diagnosis of modernity; third, he dealt with the subjective constitutions of space in his shorter, essayistic writings. This paper argues that the importance of the third strand for a sociological understanding of space has seldom been recognized in sociology. In addition, it also shows that despite the diversity in perspectives, there is an underlying coherence to Simmel’s theory of space. As a result, it becomes evident that Simmel was not only ground-breaking in conceptualizing space from a sociological point of view, but that his theory of space continues to be inspirational and relevant to this day for interpreting the entanglement of social and spatial relations.
Global longitudinal strain: an early marker for cardiotoxicity in patients treated for breast cancer
Authors: van der Linde D. , van Hagen I. , Veen K. , Zuetenhorst H. , van Dalen B. 
Published: November 2022

Abstract
Background
Patients treated with anthracyclines and trastuzumab are at increased risk of developing heart failure. Early diagnosis and treatment may prevent irreversible left ventricular (LV) dysfunction. This study investigates whether subclinical deterioration of global longitudinal strain (GLS) is a more reliable early predictor for LV dysfunction than three-dimensional (3D) LV ejection fraction (LVEF).

Methods
Adult patients receiving anthracyclines and trastuzumab for breast cancer who had serial echocardiographic follow-up were included in this retrospective study. The primary endpoint was the necessity to temporarily pause chemo- or immunotherapy due to declining LVEF (decline in 3D LVEF of > 10 percentage points to < 53%). Linear mixed-effects models were used to assess the longitudinal evolution of 3D LVEF and GLS over time.

Results
Fifty-one women were included, mean age 54 (50.5–57.6) years, with a total of 216 follow-up echocardiograms (mean follow-up 1.1 ± 0.45 years). GLS and 3D LVEF were significantly correlated (Spearman’s rho: −0.36, p < 0.001). A decrease in GLS significantly predicted a lower LVEF on the subsequent echocardiogram [ß −0.6, 95% confidence interval (CI) (−1.0 to −0.2), p < 0.006]. Conversely, prior LVEF did not significantly predict GLS on the subsequent echocardiogram [ß −0.04, 95% CI −0.1 to −0.01, p = 0.12]. Nine patients reached the primary endpoint. On average, patients who reached the primary endpoint had a relative decrease of 15% GLS at day 205 and an absolute 10% decrease of LVEF to LVEF < 53% at day 235.

Discussion
GLS is able to identify subclinical LV dysfunction earlier than 3D LVEF measurement in women undergoing treatment for breast cancer with anthracyclines followed by trastuzumab.
Desmoplakin cardiomyopathy—an inherited cardiomyopathy presenting with recurrent episodes of acute myocardial injury
Authors: Schoonvelde S. A. C. , Hirsch A. , Yap S. C. , Verhagen J. M. A. , van Slegtenhorst M. A. , Segers D. , van Loon J. E. , Michels M. 
Published: November 2022

AbstractWe present two female patients with recurrent episodes of myocardial injury, consisting of acute chest pain and elevated cardiac markers without coronary artery disease. Cardiovascular magnetic resonance imaging identified extensive late gadolinium enhancement suggestive of an inherited cardiomyopathy. Genetic testing showed heterozygous pathogenic variants in the desmoplakin (DSP) gene, the gene coding for the desmoplakin protein, a structural protein found in the cardiac desmosome. Pathogenic variants in the DSP gene are associated with dilated and arrhythmogenic cardiomyopathy. DSP cardiomyopathies may cause recurring myocardial injury mimicking an acute coronary syndrome or myocarditis. Cardiac magnetic resonance imaging is key in its diagnosis due to its specifying imaging features. Genetic testing is essential for the evaluation and confirmation of the diagnosis.