bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in the development of industrial production in Russia: regional aspect
Authors: Измайлов М.К. 
Published: March 2022

В статье проведено исследование региональной дифференциации промышленного производства России. Проведен подробный анализ статистических данных с разбивкой по отдельным федеральным округам, отражающий динамику и структуру объемов промышленного производства, объемов производства по отрасли добычи полезных ископаемых и по обрабатывающей промышленности. Обоснована необходимость использования в региональной промышленной политике концепции умной специализации, отражены ее основные принципы и направления реализации в условиях российской экономики.
The article studies the regional differentiation of industrial production in Russia. A detailed analysis of statistical data is carried out, broken down by individual federal districts, reflecting the dynamics and structure of industrial production volumes, production volumes by the mining industry and by the manufacturing industry. The necessity of using the concept of smart specialization in regional industrial policy is substantiated, its basic principles and directions of implementation in the conditions of the Russian economy are reflected.
Simulation tools for approach selection when solving the multicriteria traveling salesman problem
Authors: Светушков Н.Н. , Перепелица К.А. 
Published: March 2022

Развитие глобальной экономики приводит к возникновению различных логистических задач по оптимизации как маршрутов доставки, так и необходимости уложиться в заданные временные интервалы для каждого из клиентов. Полный перебор при большом количестве заказчиков, как известно, вызывается определённые проблемы даже на современной вычислительной базе. Поэтому методы решения классической задачи коммивояжёра остаются актуальными, тем более, что возникают специализированные программные среды, которые позволяют не только отобразить найденный маршрут, но и привязать его к реальной карте местности. Дополнительное преимущество, связанное с имитационным моделированием оптимизации процессов доставки, является возможность найти не один маршрут, а целый набора с различными, но близкими по значению критериями оптимальности, что может помочь глубже проанализировать текущую задачу в случае возникновения каких-либо непредвиденных ситуаций. В статье анализируются возможности программной среды имитационного моделирования AnyLogic и предлагается новый алгоритм перебора, основанный на выделении отдельных групп клиентов. Совмещение предлагаемого алгоритма с возможностями AnyLogic позволит создать законченное информационное приложение, которое можно использовать при практической работе в логистических компаниях.
Тhe development of the global economy leads to the emergence of various logistics tasks to optimize both delivery routes and the need to meet the specified time intervals for each of the customers. Completely full search with a large number of customers, as is known, might to cause certain problems even on a modern computing base. Therefore, methods for solving the classic traveling salesman problem remain relevant, especially since specialized software environments are emerging that allow not only displaying the found route, but also linking it to a real map of the area. An additional advantage associated with simulation modeling of the optimization of delivery processes is the ability to find not one route, but a whole set with different but similar optimality criteria, which can help to analyze the current task in depth in the event of any unforeseen situations . The article analyzes the capabilities of the software environment for simulation AnyLogic and proposes a new search algorithm based on the selection of individual groups of clients. Combining the proposed algorithm with the capabilities of AnyLogic will create a complete information application that can be used in practical work in logistics companies.
Conceptual foundations of the numerical expert method of synergetic optimization of complex rocket and space objects during their research advance design
Authors: Вокин Г.Г. , Егоров О.В. 
Published: March 2022

В статье излагаются основы предлагаемого метода выбора параметров сложных проектируемых объектов в заданных диапазонах их значений, которые отыскиваются, исходя из условия, что ведущие показатели эффективности будут достигать максимальных значений, а сопутствующие показатели будут находиться в заданных диапазонах ограничений. Метод является, по существу, инструментом компьютерной поддержки проектантов при поисковом исследовательском аванпроектировании сложных технических объектов, нацелен в конечном итоге на выбор синергетически оптимальных конструкторских решений и сокращение трудозатрат на этапе поиска и формирования предпочтительных вариантов технических обликов проектируемых изделий ракетно-космической техники.
The article outlines the basics of the proposed method for selecting the parameters of complex projected objects in the specified ranges of their values, which are found based on the condition that the leading performance indicators will reach the maximum values, and the accompanying indicators will be in the specified ranges of values. The method is, in essence, a tool for computer support of designers in the search and research design of complex technical objects, aimed ultimately at choosing synergistically optimal design solutions and reducing labor costs at the stage of searching and forming preferred variants of the technical appearance of the designed products of rocket and space technology.
AİLE EĞİTİM PROGRAMI (AEP) VE EBEVEYNLİK BECERİLERİ ARASINDAKİ İLİŞKİLERİN YARARLANICILARIN GÖZÜNDEN İNCELENMESİ: KONTROL GRUPLU BİR ÇALIŞMA
Authors: ŞEN KARADAĞ Öznur , TUNCAY Tarık 
Published: March 2022

Bu araştırma Aile ve Sosyal Hizmetler Bakanlığınca düzenlenen Aile Eğitim Programı’nın (AEP) yararlanıcılarda pozitif ebeveyn-çocuk ilişkisi kurma ve ebeveynlik becerilerini geliştirmeyle olan ilişkisini incelemek amacıyla gerçekleştirilmiştir. Araştırmada kontrol gruplu nicel desen kullanılmıştır. Katılımcılar Karabük ilinde AEP’e katılan 77 kişiden oluşan uygulama grubu ve bu eğitime katılmamış 100 kişiden oluşan kontrol grubunu içermektedir.
Uygulama ve kontrol grubunun sosyo-demografik özelliklerinin birbiriyle benzer olduğu, ebeveyn bilgi formu ve Çocuk-Anababa İlişki Ölçeği kullanılarak yapılan karşılaştırmada, uygulama grubunun kontrol grubuna göre çocuğun gelişim dönemleriyle ilgili daha fazla bilgi sahibi olduğu, daha az olumsuz disiplin yöntemleri kullandığı, daha demokratik tutumlar benimsediği ve daha olumlu bir ebeveyn-çocuk ilişkisi kurduğu görülmüştür. Bu araştırma yoluyla ulaşılan sonuçlar doğrultusunda; aile eğitim programının yaygınlaşarak daha çok kişiye ulaşılması, ebeveynlik becerilerinin geliştirilmesinde ve çocukların riskli davranışlarının azaltılmasında katkılar sağlanacağı düşünülmektedir.
Perceptions of drinking water access and quality in rural indigenous villages in Fiji
Authors: Nelson Sarah , Thomas Jacqueline , Jenkins Aaron , Naivalu Kelera , Naivalulevu Timoci , Naivalulevu Vilisi , Mailautoka Kinikoto , Anthony Shylett , Ravoka Mereia , Jupiter Stacy D. , Mangubhai Sangeeta , Horwitz Pierre , Abimbola Seye , Negin Joel 
Published: March 2022

Abstract
Poor rural water quality is a health challenge in Fiji. A mixed-methods study in six iTaukei (Indigenous Fijian) villages was conducted to understand local perceptions of drinking water access and quality, how this changes drinking water source choices, and impacts of age and gender. Seventy-two household surveys, 30 key informant interviews (KIIs) and 12 focus group discussions (FGDs) were conducted. Household surveys revealed 41.7% of community members perceived their water as dirty and 76.4% perceived their water as clean. Two-thirds of households reported that they always or usually had enough water. FGDs and KIIs revealed water access and quality was influenced by population size, seasonality, and rainfall. Perceptions of water quality caused villages to shift to alternative water sources. Alignment of the qualitative and quantitative data identified four themes: sources and infrastructure, access, quality and contamination. There was mixed alignment of perceptions between access and quality between the household surveys, and KIIs and FGDs with partial agreement sources and infrastructure, and quality. Gender was found to influence perceptions of dirty water, contamination, and supply and demand. Perceptions of water quality and access shape decisions and choices for water sources and can be used to inform resilience and inclusive water strategies.
Adsorption of humic acid fractions by a magnetic ion exchange resin
Authors: Ding Lei , Wang Dandan , Li Ling , Jia Yunhan , Ma Jiangya , Wang Feifei , van der Hoek Jan Peter 
Published: March 2022

AbstractNatural organic matter in waters varies in different fractions. To better understand the removal of different fractions by a magnetic ion exchange (MIEX) resin and the mechanism behind it, this study investigated adsorption kinetics, equilibrium and thermodynamics of humic acid (HA) fractions with different hydrophilic–hydrophobic properties and molecular weights on MIEX resin through a series of batch experiments. MIEX resin can effectively remove approximately 40% of hydrophilic and 30% of hydrophobic HA components, as well as approximately 44% of molecular weight (MW) &lt;10 kDa to some degree. The removal efficiency of HA fractions by MIEX resin reduced with the increase of pH from 6 to 9. Adsorption kinetics of different HA fractions on MIEX resin fitted the pseudo-second-order model well. With the increase of MW of HA from &lt;1 kDa to &gt;10 kDa, the time to reach adsorption equilibrium reduced from 180 to 120 min. It took more time for the hydrophilic fractions (140 min) to reach the equilibrium than for hydrophobic HA fractions (120 min). The Sips model fitted the adsorption equilibrium data of HA fractions on MIEX resin well. It was revealed that the adsorption of HA fractions on MIEX resin was spontaneous, endothermic and an entropy driven process, and the chemisorption might dominate the adsorption of HA components on MIEX resin. This study is of great significance to the design of magnetic ion exchange resin reactors and the optimization of operational parameters for the removal of natural organic matter with different hydrophilic–hydrophobic properties and molecular weights in different water sources.
Anthracene-9,10-Diones and Aza Bioisosteres as Antitumor Agents
Authors: Krapcho A. Paul , Maresch Martin J. , Hacker Miles P. , Hazelhurst Lori , Menta Ernesto , Oliva Ambrogio , Spinelli Silvana , Beggiolin Gino , Giuliani Fernando C. , Pezzoni Gabriella , Tognella Sergio 
Published: March 2022

Abstract:
Naturally occurring quinones which structurally consist of an anthracene-9,10-dione chromophore are important antitumor agents. The anthracycline antibiotics, in particular, doxorubicin, are major chemothera­
peutic agents. The pluramycins and the ene-diynes antibiotics also show pro­	i mise as antitumor drugs. The synthetic anthracene-9,10-diones such as mitoxantrone are potent antitumor agents. Analogues related to mitoxantrone have been synthesized and biologically evaluated. Aza and diaza bioisosteres related to the anthracene-9,10-diones have
been prepared and evaluated and several of these chemotypes show promise for development as anticancer agents. This review will discuss the discovery of cytotoxic anthracene-9,10-diones and the synthesis and antitumor properties of the related aza and diaza bioisosteres.
Biologically Active Cyclopropanes and Cyclopropenes
Authors: Salaon J. , Baird M.S. 
Published: March 2022

Abstract:
The variety of biological systems which are modulated by naturally occurring cyclopropanes has only been realized recently. They range from antibiotic, antiviral, antifungal and insecticidal activities, control of plant growth and fruit ripening, antimycotic, thyromimetic, hormonal, carcinogenic or antitumoral activities, enzyme and gluconeogenesis inhibitions, to neuro­ chemical activity. Cyclopropanes are also major components of membranes,
for instance in tuberculosis cells, and key intermediates in many biosynthetic processes. Many synthetic drugs include cyclopropanes in their structure and they are also widely used to probe the mechanisms of biological processes.
Naturally occurring cyclopropenes are known to be potent enzyme inhibitors controlling key processes on the fatty acid desaturation cycle and, in one case, to be an antibacterial agent. Synthetic analogues similarly inhibit pheromone production in insects, and the production of bacterial membranes, and interfere with the behaviour of insects by blocking pheromone receptors.
When they have been demonstrated, the mechanisms responsible for the specific bioactivity of these systems are also reviewed.
Targeting Growth Factor Receptors with Bispecific Molecules
Authors: Mokotoff Michael , Chen Jian , Zhou Jie-Hua , Ball Edward D. 
Published: March 2022

Abstract:
Peptide growth factor receptors on the surface of malignant cells bind to their ligands with high affinity, resulting in intracellular responses which cause differentiation, growth, and the survival of these cells. Peptide growth factors, or monoclonal antibodies (mAbs) which target growth factor receptors, have been conjugated to drugs, toxins, radionuclides, or other
mAbs that recognize/activate effector cells which can phagocytose or kill. These types of conjugated products, whrch have the ability to kill malignant cells, we call bispecific molecules (BsMol) and is the basis of this review article. The growth factors/receptors covered include α- and β-melanocyte stimulating hormone (MSH), bombesin/gastrin releasing peptide (BN/GRP), epidermal growth factor (EGF), HER-2/neu oncogene protein (p185HER2), interleukin-2, and somatostatin. The preparation and biological use/activity of the following BsMol are discussed:
β-MSH-daunomycin, [Nie4,D-Phe7]MSH-anti-CD3, 111In-DTPA-bis-α -MSH, DAB389-MSH, mAb22-Lys-BN, mAb22-Antag1, anti-EGFR/anti-CD3, DOXER2, DAB389EGF, 1111n-DTPA-225, anti- p185HER2-SAP, 2B1, MDX-210, humAb4D5-8 x humAbUCHT1, DAB 486 1L-2,1111n-DTPA-
octreotide (OctreoScan® ), OX-26-NGF, and IVA039.1.
Recent Developments Cannabinoids in the Medicinal Chemistry of Cannabinoids
Authors: Huffman J. W. , Lainton J. A. H. 
Published: March 2022

Abstract:
As a result of the recognition of a cannabinoid receptor, the isolation of the first endogenous cannabinoid and, more recently, the significant discovery of a cannabinoid antagonist, there has been a resurgence of interest in the medicinal chemistry of cannabinoids. This has included inter alia investigations into the effects of side chain substitution and overall molecular geometry on the biological activity of traditional cannabi­
noids, which are partially reduced dibenzopyrans, as well as the design and synthesis of a
variety of non-traditional cannabinoids. These compounds include indole and pyrrole derivatives, which are agonists, a diarylpyrazole, which is the first cannabinoid antagonist, and various amides of arachidonic acid. The latter compounds are patterned on anandamide (arachidonic acid ethanolamide), the first endogenous cannabinoid isolated from mammalian brain tissue. Modeling studies of the cannabinoid receptor are beginning to provide some insight into the interaction of various agonists with the receptor. This article will review recent developments in the medicinal chemistry of cannabinoids with an emphasis on work reported since 1992.
Tuftsin and Tuftsin	Analogs:	Biology, Synthesis and Design Theory
Authors: Nishioka Kenji , McMurray John , AI	Obeidi Fahad , Pettitf B. Montgomery 
Published: March 2022

Abstract:
We have reviewed aspects of the medicinal chemistry of Tuftsin. Biochemical and clinical aspects including physioogy and assays are briefly
accounted for. Structure-activity relationships found in the literature provide a link between the
synthetic/design strategies and the biological response. Directed rational design and synthetic techniques are reviewed for both tuftsin and its analogs.
Metabolic Activation and Detoxification of Arylamines
Authors: Hanna Patrick E. 
Published: March 2022

Abstract:
A number of important therapeutic agents, such as the sulfonamide antibacterials, dapsone, and procainamide are primary arylamines. Human exposure to arylamines also occurs through smoking tobacco and consuming cooked meat, and in various occupational settings. The principal detoxification pathway for most primary arylamines involves metabolic conversion to an arylamide in an acetyl coenzyme A-dependent,
N-acetyltransferase-catalyzed reaction. Although arylamines produce a wide range of toxicological responses, including hypersensitivity reactions and carcinogenesis, metabolic transformation to an N-hydroxyarylamine is required for most such compounds to manifest their untoward effects. Further conjugative metabolism of the N-hydroxylated arylamines is often involved in the production of reactive, electrophilic metabolites which form covalent adducts with biological macromolecules. This review describes the roles of specific enzyme systems in the biotransformation of arylamines and the chemical characteristics of arylamine metabolites that influence their toxicity, fate and disposition. The influence of interindividual genetic variability on the toxification and detoxification of arylamines is also addressed. In particular, genetic regulation of acetyltransferase activity is an important determinant of susceptibility to the toxicity and carcinogenicity of arylamines.
FIGNL1 Expression and its Prognostic Significance in Pan-cancer Analysis
Authors: Li Minghao , Zhen Zicheng , Zhong Muyan , Ye Liqun , Ma Xiaofang 
Published: March 2022

Background:
Fidgetin-like 1 (FIGNL1), a subfamily member of ATPases, is associated
with diverse cellular activities (AAA proteins). FIGNL1 is involved in DNA repair. However, the
latest study has indicated that FIGNL1 plays a crucial role in the occurrence and development of
malignant tumors.

Methods:
FIGNL1 expression was analyzed via Oncomine and GEPIA databases, and its prognostic
potential was analyzed using OncoLnc, UALCAN, and GEPIA databases. Moreover, the promoter
methylation of FIGNL1 was analyzed through the UALCAN database. FIGNL1-related gene
network was found within STRING. Gene Ontology (GO) annotation and Kyoto Encyclopedia of
Genes and Genomes (KEGG) pathways were investigated across WebGestalt. FIGNL1 correlation
with cancer immune infiltrates was estimated using the Tumor Immune Estimation Resource
(TIMER) database.

Results:
We found that FIGNL1 is widely overexpressed in multiple human cancers, and its high
expression was correlated with the poor prognosis of patients with kidney renal clear-cell carcinoma
(KIRP), low-grade glioma (LGG) of brain and liver hepatocellular carcinoma (LIHC). Additionally,
the promoter methylation level of FIGNL1 showed a statistical significance between normal
and primary tissues in KIRP and LGG via the UALCAN (P < 0.0001). FIGNL1 expression
was highly correlated with the infiltrating levels of CD8+ T and CD4+ T cells, dendritic cells
(DCs), macrophages, and neutrophils in LIHC.

Conclusions:
In this study, the correlation of FIGNL1 expression with the prognosis, promoter
methylation, and immune infiltrates in KIRP, LGG, and LIHC was revealed. These findings suggested
that FIGNL1 promised to be a prognostic biomarker for KIRP, LGG, and LIHC.
The Emerging Role of Janus Kinase Inhibitors in the Treatment of Cancer
Authors: Karati Dipanjan , Mahadik Kakasaheb Ramoo , Trivedi Piyush , Kumar Dileep 
Published: March 2022

Abstract:
Cancer is a leading cause of death worldwide. The Janus kinase (JAK) signal transducer
and activator of transcription (STAT) signalling pathway are activated abnormally, which promotes
carcinogenesis. Several cytokines are important cancer drivers. These proteins bind to receptors and
use the Janus kinase (JAK) and STAT pathways to communicate their responses. Cancer risks are
linked to genetic differences in the JAK-STAT system. JAK inhibitors have been shown to reduce
STAT initiation, tissue propagation, and cell existence in preclinical investigations involving solid
tumour cell line models. JAK inhibitors, notably ruxolitinib, JAK1 or 2 blockers, make cell lines and
mouse models more susceptible to radiotherapy, biological response modifier therapy, and oncolytic
viral treatment. Numerous JAK antagonists have been or are now being evaluated in cancerous patients
as monotherapy or by combining with other drugs in clinical studies. In preclinical investigations,
certain JAK inhibitors showed promising anticancer effects; however, clinical trials explicitly
evaluating their effectiveness against the JAK/STAT system in solid tumours have yet to be completed.
JAK inhibition is a promising strategy to target the JAK/STAT system in solid tumours, and
it deserves to be tested further in clinical studies. The function of directing Janus kinases (JAKs), an
upstream accelerator of STATs, as a technique for lowering STAT activity in various malignant circumstances
is summarized in this article, which will help scientists to generate more specific drug
molecules in the future.
Highly Reactive Heterogeneous Nanofibers Catalyst based on [Mo154] Clusters
for Green Aerobic Oxidation of Sulfur Mustard Analogues under Ambient
Conditions
Authors: Haddad Reza 
Published: March 2022

Background:
Due to the increasing chemical and biological threats posed by terrorist attacks, there is a need to design and prepare nanofibers (NFs) with the ability to neutralize CWAs. For this purpose polyacrylonitrile NFs and polyoxomolybdate [Mo154] (abbreviated as PAN NFs/[Mo154]) as a heterogeneous catalyst was prepared by electrospinning method with a diameter of about 100nm.

Objective:
The PAN NFs/[Mo154] catalyze the selective aerobic oxidation of sulfur mustard stim-ulants, such as 2-chloroethyl ethyl sulfide (2-CEES) and 2-chloroethyl phenyl sulfide (2-CEPS) under green and “ambient” conditions (25 oC, 1atm O2) in the presence of ethanol with high efficiency and selectivity. 2-CEES was selected as a model reaction to optimize the parameters of the reaction.

Method:
The progress of the reaction was evaluated after different times using GC-FID, GC-MS and TLC. The reaction product was also confirmed by 1H-NMR spectroscopy.

Result:
The aerobic oxidation results of 2-CEES showed that PAN NFs/[Mo154] have a conver-sion of 98% to produce only a nontoxic product, 2-CEESO with the selectivity of 100% after 45min. The results were performed using [Mo154] without any PAN NFs for comparison whereas [Mo154] converts only 52% of 2-CEES under identical conditions.

Conclusion:
Heterogeneous PAN NFs/[Mo154] catalyst was reused after washing with solvent up to 5 steps without leaching of [Mo154] from PAN NFs and without any loss in efficiency due to the morphology of NFs. In addition to the recovery of PAN NFs/[Mo154] in different cycles, the use of FT-IR, UV-Vis and TEM techniques confirms the stability and morphology of PAN NFs/[Mo154] after the fifth cycle, 2-CEES oxidation. According to our information, this report is the first use of PAN NFs enriched with [Mo154] for aerobic oxidation of sulfur mustard simulants.