bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of hypertension therapy based on 2020 International Society of Hypertension guidelines in Ethiopia from a societal perspective
Authors: Davari Majid , Sorato Mende Mensa , Kebriaeezadeh Abbas , Sarrafzadegan Nizal 
Published: August 2022

Introduction
There is inadequate information on the cost-effectiveness of hypertension based on evidence-based guidelines. Therefore, this study was conducted to evaluate the cost-effectiveness of hypertension treatment based on 2020 International Society of Hypertension (ISH) guidelines from a societal perspective.

Methods
We developed a state-transition Markov model based on the cardiovascular disease policy model adapted to the Sub-Saharan African perspective to simulate costs of treated and untreated hypertension and disability-adjusted life-years (DALYs) averted by treating previously untreated adults above 30 years from a societal perspective for a lifetime.

Results
The full implementation of the ISH 2020 hypertension guidelines can prevent approximately 22,348.66 total productive life-year losses annually. The incremental net monetary benefit of treating hypertension based was $128,520,077.61 US by considering a willingness-to-pay threshold of $50,000 US per DALY averted. The incremental cost-effectiveness ratio (ICER) of treating hypertension when compared with null was $1,125.44 US per DALY averted. Treating hypertension among adults aged 40–64 years was very cost-effective 625.27 USD per DALY averted. Treating hypertensive adults aged 40–64 years with diabetes and CKD is very cost-effective in both women and men (i.e., 559.48 USD and 905.40 USD/DALY averted respectively).

Conclusion
The implementation of the ISH 2020 guidelines among hypertensive adults in Southern Ethiopia could result in $9,574,118.47 US economic savings. Controlling hypertension in all patients with or with diabetes and or CKD could be effective and cost-saving. Therefore, improving treatment coverage, blood pressure control rate, and adherence to treatment by involving all relevant stakeholders is critical to saving scarce health resources.
Seasickness among Icelandic seamen
Authors: Arnardottir Nanna Yr , Jonsdottir Sigridur Sia , Petersen Hannes 
Published: August 2022

Introduction
The working environment abroad a ship is unique, with constant stimuli such as rolling of the vessel, noise, and vibration. Fishing industry is important for Icelandic economy, still the effect of seasickness-related symptoms on seamen´s health is not fully understood. Thus, the objective of this study is to explore the impact of seasickness-related symptoms, i.e., seasickness, seasickness symptoms and mal de débarquement on seaman´s health, and how their working environment may affect those factors.

Methods
Cross-sectional data was collected from 262 seamen answering questionnaire. Majority of the seamen participated while attending a compulsory course held by the Maritime Safety and Survival Training Centre. The majority of participants were men. A chi-square test was used to detect the difference between variables.

Results
The majority of seamen had experienced seasickness (87.8%) or mal de débarquement (85.8%). Having a history of tension headache (38.1%) and tinnitus (37.9%) was quite common. A total of 30.6% of the participants had been admitted to hospital once or more due to mishaps or accidents on land.

Discussion
Seasickness and seasickness symptoms together with mal de débarquement are common in Icelandic seamen. Working conditions at sea are demanding and seam to affect the seamen´s health both at sea and ashore, making further research needed.
Mutational analysis in sodium-borate cotransporter SLC4A11 in consanguineous families from Punjab, Pakistan
Authors: Iqbal Afia , Naz Shagufta , Kaul Haiba , Sharif Saima , Khushbakht Aysha , Naeem Muhammad Asif , Iqtedar Mehwish , Kaleem Afshan , Firasat Sabika , Manzoor Farkhanda 
Published: August 2022

Aim
To identify the molecular basis of Congenital Hereditary Endothelial Dystrophy CHED caused by mutations in SLC4A11, in the consanguineous Pakistani families.

Methods
A total of 7 consanguineous families affected with Congenital Hereditary Endothelial Dystrophy were diagnosed and registered with the help of ophthalmologists. Blood samples were collected from affected and unaffected members of the enrolled families. Mutational analysis was carried out by DNA sequencing using both Sanger and Whole Exome Sequencing (WES). Probands of each pedigree from the 7 families were used for WES. Results were analyzed with the help of different bioinformatics tools.

Results
The sequencing results demonstrated three known homozygous mutations in gene SLC4A11 in probands of 7 families. These mutations p.Glu675Ala, p.Val824Met, and p.Arg158fs include 2 missense and 1 frameshift mutation. The mutations result in amino acids that were highly conserved in SLC4A11 across different species. The mutations were segregated with the disease phenotype in the families.

Conclusion
This study reports 3 mutations in 7 families. One of the pathogenic mutations (p.R158fs) was identified for the first time in the Pakistani population. However, two mutations (p.Glu675Ala, p.Val824Met) were previously reported in two and one Pakistani family respectively. As these mutations segregate with the disease phenotype and bioinformatics tool also liable them as pathogenic, they are deemed as probable cause of underlying disease.
Barriers and enablers to the effective implementation of robotic assisted surgery
Authors: Lawrie Louisa , Gillies Katie , Duncan Eilidh , Davies Loretta , Beard David , Campbell Marion K. 
Published: August 2022

Background
Implementation of Robotic Assisted Surgery (RAS) is complex as it requires adjustments to associated physical infrastructure, but also changes to processes and behaviours. With the global objective of optimising and improving RAS implementation, this study aimed to: 1) Explore the barriers and enablers to RAS service adoption, incorporating an assessment of behavioural influences; 2) Provide an optimised plan for effective RAS implementation, with the incorporation of theory-informed implementation strategies that have been adapted to address the barriers/enablers that affect RAS service adoption.

Methods
Semi-structured interviews were conducted with RAS personnel and stakeholders, including: surgeons, theatre staff, managers, industry representatives, and policy-makers/commissioners. The Theoretical Domains Framework (TDF) and the Consolidated Framework for Implementation Research (CFIR) was used to identify barriers and enablers that represent individual behaviours, capabilities, attitudes, beliefs, and external organisational factors that influence the implementation of RAS.

Results
Findings suggest that implementation planning has three separate phases–pre-, early, and late implementation. For pre-implementation, barriers and enablers identified included the cost of RAS equipment and issues of economic viability, weak outcome evidence for RAS, a preponderance of an eminence driven model, the clinician/manager relationship, and views around the uptake and expansion of RAS in the future. Early implementation findings revealed role changes for theatre personnel and an enhanced team approach, reliance on industry for training provision, and changes in skill sets and attentional processes. Late implementation factors included equipment maintenance costs, technological limitations, changes to cognition during RAS routine use, and benefits to institutions/healthcare professionals (such as ergonomic improvement).

Conclusion
Together, findings suggest the factors that affect RAS implementation are multi-faceted and change across the life-cycle of intervention adoption. Theory-informed strategies are suggested which can optimise implementation of RAS. Optimisation strategies need planning from the outset.
Knowledge of oral health during pregnancy and associated factors among pregnant mothers attending antenatal care at South Omo Zone public hospitals, Southern Ethiopia, 2021
Authors: Wassihun Biresaw , Ayinalem Abayineh , Beyene Kassaw 
Published: August 2022

BackgroundThe awareness of women towards oral health during pregnancy is an important aspect of her general health. It can compromise pregnancy outcomes, as well as it may affect the newborn’s overall health. Every pregnant woman plays a critical role in shaping the oral hygiene habits adopted by her if she is aware of pregnancy-related oral health and result in good perinatal outcomes. This study aimed to assess knowledge of oral health during pregnancy and associated factors among pregnant mothers who attend antenatal care at South Omo Zone public hospitals, Southern Ethiopia, 2021.MethodsAn institution-based cross-sectional study was conducted among pregnant women attending routine antenatal care from October 01 to November 30. A systematic random sampling method was conducted to select study participants. Data had been collected through face-to-face interviews using semi-structured questionnaires. Data were entered using epi data version 3.1 and exported to Statistical Package for the Social Sciences version 25 for data analysis. Descriptive statistics had calculated for each variable, and binary logistic regression analysis with 95% confidence intervals was carried out to assess the factors associated with the outcome variables. Variables with P-value less than 0.05 were used to declare statistical significance.ResultOverall good knowledge of pregnant mothers regarding oral health was 34.1% with 95% CI, (32.76, 35.44). Having access to health facility (AOR = 2.60, 95% CI, 1.44, 4.70), having the educational status of secondary and above (AOR 1.37, 95% CI, 1.44, 4.31), having the educational status of primary education (AOR = 0.43, 95% CI, 0.20, 0.92), having a median income of > = 1500 Ethiopian birr (AOR = 0.41, 95% CI, 0.23, 0.72), being governmental employee (AOR = 0.11, 95% CI, 0.03, 0.41), received oral health hygiene counseling during pregnancy (AOR = 1.33, 95% CI, 1.62, 2.84) were significantly associated with good knowledge of oral health of pregnant mothers.ConclusionThis study showed that the knowledge of pregnant mothers about oral health was 34.1%. Educational status, monthly income, occupation, access to health services, and receiving counseling on oral hygiene at antenatal care were some factors associated with good knowledge of oral health during pregnancy. Therefore strengthening counseling during antenatal care, improving access to a health facility, improving educational status, monthly income, and being government employee are crucial to enhance knowledge of women towards oral health during pregnancy.
A scoping review protocol to elucidate outcomes following abiraterone versus enzalutamide for prostate cancer
Authors: Shah Yash B. , Shaver Amy L. , Kelly William Kevin , Lu-Yao Grace 
Published: August 2022

Introduction
Abiraterone acetate and enzalutamide are commonly employed in prostate cancer therapy in an interchangeable manner. These drugs are highly efficacious in androgen antagonism to improve patient outcomes, but they also carry noteworthy risk of adverse effects. Common toxicities vary amongst the two drugs and may have differential interactions with patient co-morbidities, but these patterns are unclear as co-morbidities typically serve as exclusion criteria in clinical trials. Hence, there is no existing guidance on how clinicians may tailor treatment based on patient-specific factors. Analysis of differential patient outcomes between these two drugs can inform future systematic reviews, new clinical studies, and clinical decision making.

Method and analysis
The framework for this methodology was informed by the Joanna Briggs Institute methodology for scoping reviews. Title and abstract screening will be performed by two independent researchers to create an initial study inventory. This will be followed by full-text screening for study inclusion. Population-based studies describing patient outcomes, common toxicities, and associations with patient co-morbidities following abiraterone or enzalutamide therapy will be included. After data is extracted, it will be summarized for presentation.

Ethics and dissemination
The findings of this scoping review will be published in a peer-reviewed journal. The results will be used to inform future studies on patient-specific factors informing treatment choice between abiraterone and enzalutamide for castration-resistant prostate cancer. All data are from published openly accessible sources, and therefore, no ethical clearance is necessary. The protocol is also registered at https://doi.org/10.6084/m9.figshare.19149227.
Interpolation inequalities for partial regularity
Authors: Hamburger Christoph 
Published: August 2022

Abstract
We propose two new direct methods for proving partial regularity of
solutions of nonlinear elliptic or parabolic systems. The methods are based
on two similar interpolation inequalities for solutions of linear systems
with constant coefficient. The first results from an interpolation
inequality of

L
p

{L^{p}}

norms in combination with an

L
p

{L^{p}}

estimate with low
exponent

p
>
1

{p>1}

. For the second, we provide a functional-analytic proof, that
also sheds light upon the A-harmonic approximation lemma of Duzaar and
Steffen. Both methods use a Caccioppoli inequality and avoid higher
integrability. We illustrate the methods in detail for the case of a quasilinear elliptic system.
Mullā Ṣadrā on free will and freedom
Authors: Azadani Zakieh 
Published: August 2022

Abstract
Although even before the coming of Islam, a “predestinarian view” could be identified in the Arabic tradition, and so apparently Arabs were not unfamiliar with the conflict between human free will (iḫtiyār) and predestination, after the emergence of Islam and the emphasis of Qurʾān on God’s omnipotence, this question arose more seriously in different forms in the Islamic world. It was during the Umayyad period of Islamic history that the problem of destiny became the subject of discussion between two groups of thought, the so-called Qadariyya and Ǧabriyya, and some questions raised explicitly: If human will is entirely determined by God, how would God’s justice be justified? What would happen to human responsibility for his sins? Adherents of Qadariyya believed that man is free and the agent of his own actions, and so is responsible for his deeds. In contrary, according to Ǧabriyya, man is determined by God in all his actions.
Performance of dual one-way measurements and precise orbit determination for BDSviainter-satellite link
Authors: Zhu Jun , Li Hengnian , Li Jie , Ruan Rengui , Zhai Min 
Published: August 2022

AbstractThe continuous full operation of the constellation of BeiDou navigation satellite system (BDS) provides favorable conditions for the performance evaluation of the BDS inter-satellite links (ISLs). The primary features of ISLs that affect the precision of precise orbit determination (POD) and time synchronization include (i) the spatiotemporal coverage or continuity of observations; (ii) the observational accuracy, such as observation noise and bias; and (iii) the observational geometry represented by dilution of precision. After comparing some technical features and the current status of the Global Navigation Satellite Systems ISLs, the measurement principle of dual one-way ISLs for BDS and its data processing methods are presented. The performance evaluation involving the above three aspects was carried out using 14 days of ISL data, with some typical indicators derived. POD based on data fusion of ISLs and ground-based L-band monitoring stations was conducted, with root-mean-square of posterior residuals of about 5.0 cm, and MEO radial accuracy better than 1.0 cm. The results show that ISLs offer crucial support for BDS to provide global high-precision services under regional monitoring network conditions.
Being and becoming an international student: the inter-relation between language socialization and identities
Authors: Soltani Behnam , Tran Ly , Reza Amir 
Published: August 2022

Abstract
This article draws on Lefebvre’s production of space to understand the cultural negotiations and underlying meanings of being and becoming an international student. Rich and multiple data sources including video/audio recordings of classroom interactions, field notes, interviews, diaries, and institutional documents from a Vietnamese student’s participation in English for Academic Purposes (EAP) and mainstream courses in a New Zealand university (NZU) were drawn upon. The findings of this study show that the student’s engagement in both the new social space and academic environment of NZU is mediated through negotiations and reflections of her Vietnamese-ness and constant comparison of the host culture with that of Vietnam and how her experience of navigating the social space of New Zealand influences her perceptions of Vietnamese-ness. International students’ socialization is mediated through engagement with materialities of space, mastering the norms of their social space, participating in activities, and reflecting on their own life and learning trajectories.
How Does the Combination of Factors Influence Entrepreneurs’ Decision-Making Logic? A Qualitative Comparative analysis
Authors: Xu Yongfei , Baranchenko Yevhen , Lin Zhibin , Wu Qin , Arakpogun Emmanuel 
Published: August 2022

Abstract
This study explores the different paths that lead to the effectuation and causation of entrepreneurial decision-making logic. Data were collected from a sample of 300 entrepreneurs in China in January and March 2018 and analyzed using crisp-set qualitative comparative analysis (csQCA). The results reveal various combinations of four key factors, i.e., environmental uncertainty, entrepreneurial experience, organizational slack, and centralization of decision-making factors, determine the effectuation or causation logics. No antecedent condition alone is necessary to produce the outcome, although several factors are identified as sufficient for the presence of effectual or causal decision-making logics. This study advances the entrepreneurship literature by revealing the combinations of factors that Knowledge of how the factors interact in the decision-making process determine entrepreneurial decision-making logic. The study findings can help entrepreneurs to better communicate, discuss and justify their decisions.
Computation and analysis of anisotropic solar radiation model for India
Authors: Makhija Amandeep Singh , Bohra Shabbir S. 
Published: August 2022

Abstract
The solar radiation data are a very important parameter to forecast generation from any solar PV (Photo Voltaic) plant to be installed at a suitable location, though it is not readily available for many locations because of the costly measurement instruments, and their maintenance, and calibration issues. The solar irradiation data available from NASA and Meteonorm has the prediction topology of consolidating 20–25 years old irradiation data which has the question of reliability. Furthermore, at various locations in India, the irradiance value of Meteonorm is overestimated than actual. In this research study an attempt has been made to develop an algorithm for the anisotropic solar radiation model by coalescing Gopinathan empirical parameter, Klucher anisotropic model, and Collares-Pereira & Rabl (GKCR) empirical parameter which gives the best results of forecasted daily and monthly solar radiation at almost every location in India. The computed results are compared with Meteonorm and the NASA database for three distinct locations (New Delhi, Chennai, and Kolkata) at different azimuths and tilt angles. The results obtained i.e., solar tilted radiation and tilt gain were very close to that simulated using PVsyst software using Meteonorm and NASA database. The computed results were compared using various statistical tools with measured irradiance values for four distinctly located solar PV plants. The computed result shows the least error compared to actual data for two locations. Employing the GKCR empirical algorithm mentioned in the research article, hourly irradiance data for the next day, for any specific tilt and azimuth angle can be estimated using available weather forecast data (sunshine duration) and can circumvent the penalty levied by the Load dispatch Centre. Furthermore, by using monthly data anticipated by the algorithm, the question of data reliability of chargeable Meteo sources working on coalescing data of antiquated years like NASA and Meteonorm can be solved.
Multi-frequency control with fuzzy 2DOFPI in HVBTB converter of LF-HVAC system
Authors: Anand Mukul , Goswami Swapan Kumar , Chatterjee Debashis 
Published: August 2022

Abstract
This paper illustrates the design of closed-loop controllers operating High Voltage Back to Back three-phase converter for frequency stabilization and power quality improvement. Simulations of the converter with Multi-frequency control with the proposed Fuzzy-2DOFPI (two degrees of freedom) are carried out in Simulink/MATLAB. Performance parameters such as frequency stabilization and source voltage total harmonic distortion (THD) are considered for comparison of the controllers with conventional ones. The fuzzy-tuned 2DOFPI controller with multi-frequency provides a better result, with a source-voltage THD of 0.23% and acts as a source-side filter for the converter. Finally, the fuzzy-tuned 2DOFPI with multi-frequency controller combination is implemented in an OPAL-RT 5650 real-time simulator for experimental validation of power quality enhancement and frequency stabilization.
Reconstruction of polytopes from the modulus of the Fourier transform with small wave length
Authors: Engel Konrad , Laasch Bastian 
Published: August 2022

AbstractLet𝒫{\mathcal{P}}be ann-dimensional convex polytope and let𝒮{\mathcal{S}}be a hypersurface inℝn{\mathbb{R}^{n}}. This paper investigates potentials to reconstruct𝒫{\mathcal{P}}, or at least to compute significant properties of𝒫{\mathcal{P}}, if the modulus of the Fourier transform of𝒫{\mathcal{P}}on𝒮{\mathcal{S}}with wave length λ, i.e.,|∫𝒫e-i⁢1λ⁢𝐬⋅𝐱⁢𝐝𝐱| for ⁢𝐬∈𝒮,\biggl{\lvert}\int_{\mathcal{P}}e^{-i\frac{1}{\lambda}\mathbf{s}\cdot\mathbf{x% }}\,\mathbf{dx}\biggr{\rvert}\quad\text{for }\mathbf{s}\in\mathcal{S},is given, λ is sufficiently small and𝒫{\mathcal{P}}and𝒮{\mathcal{S}}have some well-defined properties. The main tool is an asymptotic formula for the Fourier transform of𝒫{\mathcal{P}}with wave length λ whenλ→0{\lambda\rightarrow 0}. The theory of X-ray scattering of nanoparticles motivates this study, since the modulus of the Fourier transform of the reflected beam wave vectors is approximately measurable on a half sphere in experiments.
Using papyrus fiber ash as a sustainable filler modifier in preparing low moisture sensitivity HMA mixtures
Authors: Hashim Tameem Mohammed , Abbas Ghadeer Haider , Al-Khafaji Fatimah Fahem , Alwash Ali Abdul Ameer , Al-Mulali Mohammed Zuhear , Ali Yasar Ameer 
Published: August 2022

Abstract
In this study, a sustainable filler made from papyrus fiber ash (PFA) is used as a partial cement replacement in hot mix asphalt mixtures (HMA). The replacement levels used are 0, 5, 10, and 15% by weight of ordinary Portland cement. The hot mix asphalt samples were subjected to Marshal volumetric properties (stability, flow, and air voids) and service tests (tensile strength ratio test and immersion compression test) to predict the influence of the used filler modifier on the moisture sensitivity of blended HMA. Best results have been achieved by using 10% of PFA, whereas all the prepared samples with the mentioned percentage of the filler modifier showed a lower sensitivity to moisture in comparison with the control samples, which contained 0% of PFA. The used technique proved to be very efficient in keeping the pavement safe from deformation caused by moisture. At the same time, using sustainable filler materials proved to be an environmentally eco-friendly method.