bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal Epilepsy and Long‐term Offspring Mortality: A Nationwide Cohort Study
Authors: Christensen Jakob , Antonsen Sussie , Sun Yuelian , Dreier Julie W. 
Published: February 2022

ObjectiveWe examined how maternal epilepsy and use of antiseizure medications in pregnancy was associated with offspring mortality.MethodsThis population‐based cohort study included all live‐ and stillborn singletons in Denmark between 1981 and 2016. We used nation‐wide registers to retrieve information on pregnancy characteristics, epilepsy diagnoses, use of antiseizure medications, and mortality. Adjusted mortality rate ratios (MRR) were estimated using log‐linear Poisson regression.ResultsThe cohort consisted of 1,862,474 children. In total, 12,026 live‐born children died during follow‐up, of whom 170 (1.4%) were offspring of mothers with epilepsy. Overall mortality was increased in offspring of mothers with epilepsy compared to offspring of mothers without epilepsy (MRR = 1.46, 95% CI: 1.23–1.71), driven by an excess mortality only in the first year of life. Mortality was increased for natural deaths (MRR = 1.50, 95% CI: 1.25–1.78) but not from unnatural deaths (MRR = 1.38, 95% CI: 0.84–2.14), and only in offspring of women with epilepsy who used antiseizure medications during pregnancy (MRR = 1.51, 95% CI: 1.00–2.17), but not in offspring of women with epilepsy who did not use antiseizure medications while pregnant (MRR = 0.97, 95% CI: 0.69–1.31). When analyses were restricted to children born from 2000 and onwards, the excess mortality that was observed in the first year of life among children of mothers with epilepsy, was no longer evident.InterpretationDuring the 1981 to 1999 epoch, offspring of women with epilepsy were at increased risk of dying in the first year of life. However, this risk did not extend to children born after 2000. Future retrospective studies of the effects of maternal epilepsy on the health of the offspring should take this difference into account. ANN NEUROL 2022;91:455–465
Interfacial Fe−O−Ni−O−Fe Bonding Regulates the Active Ni Sites of Ni‐MOFs via Iron Doping and Decorating with FeOOH for Super‐Efficient Oxygen Evolution
Authors: Li Cheng‐Fei , Xie Ling‐Jie , Zhao Jia‐Wei , Gu Lin‐Fei , Tang Hai‐Bo , Zheng Lirong , Li Gao‐Ren 
Published: February 2022

AbstractThe integration of Fe dopant and interfacial FeOOH into Ni‐MOFs [Fe‐doped‐(Ni‐MOFs)/FeOOH] to construct Fe−O−Ni−O−Fe bonding is demonstrated and the origin of remarkable electrocatalytic performance of Ni‐MOFs is elucidated. X‐ray absorption/photoelectron spectroscopy and theoretical calculation results indicate that Fe‐O−Ni−O−Fe bonding can facilitate the distorted coordinated structure of the Ni site with a short nickel–oxygen bond and low coordination number, and can promote the redistribution of Ni/Fe charge density to efficiently regulate the adsorption behavior of key intermediates with a near‐optimal d‐band center. Here the Fe‐doped‐(Ni‐MOFs)/FeOOH with interfacial Fe−O−Ni−O−Fe bonding shows superior catalytic performance for OER with a low overpotential of 210 mV at 15 mA cm−2 and excellent stability with ≈3 % attenuation after a 120 h cycle test. This study provides a novel strategy to design high‐performance Ni/Fe‐based electrocatalysts for OER in alkaline media.
Important areas for cetaceans in Russian Far East waters
Authors: Filatova Olga A. , Hoyt Erich , Burdin Alexander M. , Burkanov Vladimir N. , Fedutin Ivan D. , Ovsyanikova Ekaterina N. , Shpak Olga V. , Shulezhko Tatiana S. , Titova Olga V. 
Published: February 2022

Abstract

Cetacean species are highly mobile, most of them regularly travelling over long distances, thereby presenting complex obstacles to their conservation. Identification of their critical habitats, specifically those parts of a cetacean’s range that are essential for day‐to‐day survival and for maintaining a healthy population growth rate, is necessary for their effective protection.
This study presents a summary of the data on cetacean sightings during surveys that covered substantial parts of the Russian Far East coastal waters from the Okhotsk Sea to Chukotka in order to determine important areas for particular cetacean species. Sixteen cetacean species were registered during the surveys, and for 12 of them with sufficient numbers of sightings, zones with maximum sighting rates were identified.
Only 13% of all cetacean sightings and 22% of sightings of protected species occurred within marine protected areas (MPAs). The highest sighting rates for protected species were concentrated off north‐eastern Sakhalin Island, in the Shantar Area, in Anadyr Gulf, in Kresta Bay and in the waters off eastern Chukotka. The analysis of the distribution patterns of various cetacean species in Russian Far East seas provides a solid base for future conservation planning. Lack of specific MPAs for protection of cetaceans and associated biodiversity hinders marine conservation in Russian Far East seas.
The study highlights the specific zones important for various cetacean species and suggests the extension of some existing MPAs and the creation of new MPAs for future spatial habitat protection measures.
Copper‐Catalyzed Aerobic Cross‐Dehydrogenative Coupling of β‐Oxime Ether Furan with Indole
Authors: Fernandes Rushil , Mhaske Krishna , Balhara Reena , Jindal Garima , Narayan Rishikesh 
Published: February 2022

AbstractHeterobiaryls serve as relevant structural motifs in many fields of high applicative importance such as drugs, agrochemicals, organic functional materials etc. Cross‐dehydrogenative coupling involving direct oxidation of two C−H bonds to construct a C−C bond is actively being pursued as a more benign and ‘greener’ alternative for synthesizing heterobiaryls. Herein, we report a Cu(I)‐catalyzed cross‐dehydrogenative coupling of indoles and furans, two of the most important aromatic heterocycles using air as the terminal oxidant. The reaction proceeds with regio‐ and chemoselectivity to give the cross‐coupled products in good to excellent yields generally. A broad substrate scope with respect to both the coupling partners has been demonstrated to prove the generality of this reaction. This represents the hitherto unexplored cross‐dehydrogenative coupling methodology to obtain an indole‐furan biaryl motif.
High‐gain observer‐based adaptive fuzzy finite‐time prescribed performance tracking control for linear stepping motor with event‐triggered strategy
Authors: Zhou Xin , Gao Chuang , Li Zhi‐gang , Yang Yong‐hui , Wu Li‐bing 
Published: February 2022

AbstractThis paper considers the tracking problem of linear stepping motor system with unmeasurable states, and a finite‐time prescribed performance controller is designed with dynamic surface control scheme and event‐triggered strategy. In the adaptive backstepping recursive design, fuzzy logic system is used to approximate the nonlinear function, and a high‐gain observer is introduced to estimate the unmeasured states. A finite‐time performance function is developed to improve the transient and transient performance of the system, and a relative threshold event‐triggered strategy is proposed to reduce the communication burden. In addition, the inherent complexity explosion problem of the backstepping process is solved by the dynamic surface control method. Finally, the simulation results prove the effectiveness of the scheme.
Ultra‐Small Ferromagnetic Fe3O4 Nanoparticles Modified Separator for High‐Rate and Long Cycling Lithium‐Sulfur Batteries
Authors: Yue Wence , Li Xue , Zhao Jie , Gao Yibo , Gao Ning , Li Bao , Xia Guangming , Zheng Shumin , Wang Bao 
Published: February 2022

AbstractAs a promising energy storage system with high specific capacity, lithium‐sulfur (Li−S) battery is striving for a high‐rate and longer lifetime. Whereas the slow redox kinetics and the shuttle effect of polysulfides (PSs) still severely restrict the performance of Li−S batteries. Here, a rational designed ferromagnetic Fe3O4 nanoparticles (FM‐Fe3O4 NPs) modified separator is engineered for Li−S batteries. Moreover, the particle size of FM‐Fe3O4 NPs was tuned to enhance the energy storage performance. Consequently, the cells with FM‐Fe3O4 NPs modified separator achieved a high‐rate and long cycling performance, the specific capacity could reach 672.8 mAh g−1 and a low fading rate (0.028 % per cycle over 700 cycles) at a high rate of 5 C. Experimental results reveals that FM‐Fe3O4 NPs could mitigate shuttle effect, enable efficient redox reactions, and protect the Li anode from severe corrosion. The performance‐enhanced mechanism is further discovered by DFT calculations, the results show that FM‐Fe3O4 NPs act as mediators of redox reaction to block PSs shuttle and dynamically facilitate conversion via changing the molecular structure of PSs and reducing reaction barrier. This work provides a new pathway to improving Li−S batteries based on ferromagnetic materials, which may be generalized to other advanced batteries.
Monodisperse Porous Carbon Nanospheres with Ultra‐High Surface Area for Energy Storage in Electrochemical Capacitors
Authors: Díez Noel , Sevilla Marta , Fombona‐Pascual Alba , Fuertes Antonio B. 
Published: February 2022

AbstractInvited for this month's cover picture is the group of Dr. Noel Díez. The Front Cover illustrates the use of monodisperse, highly porous carbon nanoparticles derived from polypyrrole as the electrode material in high power supercapacitors. The highly porous nanoparticles were employed to construct supercapacitors with practical mass loadings that showed a fast response in different types of electrolyte systems. Read the full text of the Article at 10.1002/batt.202100169.
A material‐based panspermia hypothesis: The potential of polymer gels and membraneless droplets
Authors: Sithamparam Mahendran , Satthiyasilan Nirmell , Chen Chen , Jia Tony Z. , Chandru Kuhan 
Published: February 2022

AbstractThe Panspermia hypothesis posits that either life's building blocks (molecular Panspermia) or life itself (organism‐based Panspermia) may have been interplanetarily transferred to facilitate the origins of life (OoL) on a given planet, complementing several current OoL frameworks. Although many spaceflight experiments were performed in the past to test for potential terrestrial organisms as Panspermia seeds, it is uncertain whether such organisms will likely “seed” a new planet even if they are able to survive spaceflight. Therefore, rather than using organisms, using abiotic chemicals as seeds has been proposed as part of the molecular Panspermia hypothesis. Here, as an extension of this hypothesis, we introduce and review the plausibility of a polymeric material‐based Panspermia seed (M‐BPS) as a theoretical concept, where the type of polymeric material that can function as a M‐BPS must be able to: (1) survive spaceflight and (2) “function”, i.e., contingently drive chemical evolution toward some form of abiogenesis once arriving on a foreign planet. We use polymeric gels as a model example of a potential M‐BPS. Polymeric gels that can be prebiotically synthesized on one planet (such as polyester gels) could be transferred to another planet via meteoritic transfer, where upon landing on a liquid bearing planet, can assemble into structures containing cellular‐like characteristics and functionalities. Such features presupposed that these gels can assemble into compartments through phase separation to accomplish relevant functions such as encapsulation of primitive metabolic, genetic and catalytic materials, exchange of these materials, motion, coalescence, and evolution. All of these functions can result in the gels' capability to alter local geochemical niches on other planets, thereby allowing chemical evolution to lead to OoL events.
CEO foreign experience and corporate sustainable development: Evidence from China
Authors: Wang Yu , Qiu Yetaotao , Luo Yi 
Published: February 2022

AbstractThis study examines the impact of CEO foreign experience on corporate sustainable development from the angle of firm green innovation. Using manually collected data of CEOs' foreign experience, we find that CEO foreign experience is positively associated with firm green innovation in China. The positive relationship between CEO foreign experience and green innovation (including green invention patents and green utility model patents) is more significant when the firm is state owned, when the firm has better corporate governance, and when the firm is subject to a better institutional environment. Further analyses indicate that both foreign work and foreign educational experiences matter; relative to experiences gained in underdeveloped countries, those related to developed economies tend to be more influential in facilitating green innovation. Finally, the documented association is robust to a series of robustness checks, including propensity score matching, instrumental variable approach, Heckman two‐stage model, and the inclusion of firm fixed effects. Overall, this paper contributes to the upper echelons perspective, and it also offers clear practical implications through showing that hiring returnee CEOs can enhance firms' sustainable development, which could be of interest to policy makers in other emerging markets.
Some Antioxidant Properties of Components from the Flower of Ochna integerrima and Their Beneficial Effects on HaCaT Keratinocytes and in Silico Analysis on Tyrosinase
Authors: Buranasudja Visarut , Kobtrakul Khwanlada , Vimolmangkang Sornkanok , Binalee Asma , Sanookpan Kittipong , Vu Thien‐Y. , Vu Huynh Kim Long , Le Bao , Nguyen Huy Truong , Do Kiep Minh , Dang Van Son , Nguyen Hien Minh 
Published: February 2022

AbstractFour compounds, luteolin (1), 6‐γ,γ‐dimethylallylquercetin 7‐O‐β‐D‐glucopyranoside (2), 6‐γ,γ‐dimethylallylkaempferol 7‐O‐β‐D‐glucopyranoside (3), and 6‐γ,γ‐dimethylallyldihydrokaempferol 7‐O‐β‐D‐glucoside (4), were isolated for the first time from AcOEt extract of the O. integerrima flower. We then evaluated the antioxidant effects of AcOEt, butanol, and MeOH extracts and their effects on H2O2 against oxidative stress in HaCaT keratinocyte cell lines. Furthermore, 2,2‐diphenyl‐1‐picrylhydrazyl hydrate (DPPH⋅) radical scavenging activities of 1–4 were determined and their mechanisms of action on tyrosinase were predicted by in silico studies. The results revealed that the AcOEt extract and 1–3 exhibited good DPPH⋅ radical scavenging activity. Furthermore, this extract also had a significant protective effect against H2O2‐induced oxidative stress in HaCaT cells. In silico studies indicated that the activity of 1–3 may be due to tyrosinase inhibition with MM‐GBSA free binding energies of −78.9, −70.1, and −71.1 kcal mol−1, respectively, compared to 4 with an energy −56.9 kcal mol−1.
Dibenzocyclooctyne‐Branched Primer Assembled Gene Nanovector and Its Potential Applications in Genome Editing
Authors: Lu Liqing , Rao Dunkang , Niu Cuili , Cheng Longhuai , Ma Dejun , Xi Zhen 
Published: February 2022

AbstractThe CRISPR/Cas9 system has been widely used as an efficient genome editing toolkit for gene therapy. The delivery of vectors encoding the full CRISPR/Cas9 components including Cas9 gene and gRNA expression element into cells is the crucial step to effective genome editing. However, the cargo gene sequence for genome editing is usually large, which reduces the cargo encapsulation efficiency and affects the vector size. To obtain a nanovector with high cargo gene loading capacity and biocompatible size, we report the construction of a gene nanovector from branch‐PCR with a dibenzocyclooctyne (DBCO)‐branched primer and establish the correlation mapping between gene length and nanovector size. The results show that the size of nanovectors can be tuned according to the gene length. According to the findings, we constructed nanovectors carrying the full CRISPR/Cas9 components in 100–200 nm and validated their application in genome editing. The results show that this kind of nanovector exhibits higher serum stability than plasmids and can reach comparable genome editing efficiency with plasmids. Hence, this type of gene nanovector obtained through branch‐PCR can carry large gene cargos and maintain a biocompatible nanoscale size, which we envisage will expand its medical applications in gene therapy.
Spontaneous pneumothorax and pneumomediastinum in patients with COVID‐19: A case series from Iran
Authors: Yassin Zeynab , Ebrahimian Mohammad , Motamedi Omid , Afshar Hale , Aloosh Oldooz , Sayyahfar Shirin , Maleki Donya , Ghorbi Mojtaba 
Published: February 2022

AbstractHere, we report six cases of spontaneous pneumothorax and pneumomediastinitis in patients with COVID‐19 in Iran, which were treated with different drugs such as hydroxychloroquine, sofosbuvir, atazanavir, and remdesivir as antiviral agents. Despite the differences in the type of drugs, pneumothorax occurred in all patients.
Safety in Laboratories – Evaluation of Experimental Competencies of Chemistry Teacher Students
Authors: Poensgen Fabian , Reiners Christiane S. 
Published: February 2022

AbstractChemielehrer:innen sind für Schüler:innen oft die einzigen professionell ausgebildeten Vorbilder beim sicheren Umgang mit gefährlichen Materialien, Geräten und Chemikalien und entfalten somit eine Wirkung auch über den Unterricht hinaus. Der laborpraktischen Bildung Lehramtsstudierender kommt insofern eine Schlüsselrolle für sicheres Experimentieren insgesamt zu. Um herauszufinden, was genau Chemielehramtsstudierende können (sollen), wurden sicherheitsbezogene experimentelle Kompetenzen modelliert und mithilfe eines videographierten, praktischen Prüfverfahrens erfasst. Die Ergebnisse der qualitativen Auswertung legen nahe, dass Sicherheit im Kontext des Experimentierprozesses erst durch ein Zusammenspiel mehrerer Faktoren möglich wird: Über die sichere Handhabung von Stoffen und Materialien hinaus sind Wissensbestände und Fähigkeiten erforderlich, Informationen auf korrektem Wege auszuwählen und zu verstehen. Grundlegend für sicheres Experimentieren im Labor und damit später in der Schule ist allerdings ein Bewusstsein für die Bedeutung von Sicherheit im experimentellen Prozess überhaupt.
Lithium‐sulfur batteries – a promising and challenging energy storage device for the future of electromobility
Authors: Lüke Dennis , Oetken Marco 
Published: February 2022

AbstractDurch die Bemühungen zur Mobilitätswende gewinnen Energiespeicher mit hoher Energiedichte zunehmend an Bedeutung. In diesem Kontext zählen Lithium‐Schwefel‐Batterien zu den vielversprechendsten Energiespeichern der Zukunft. Vor der kommerziellen Nutzung dieses spannenden Energiespeichers sind jedoch noch zahlreiche Probleme zu lösen. Einige dieser Umsetzungsschwierigkeiten lassen sich in Modellversuchen ebenso veranschaulichen, wie die Funktionsweise der Lithium‐Schwefel‐Batterie.
Recent Advances in Dual BRD4‐Kinase Inhibitors Based on Polypharmacology
Authors: Chen Li , Liu Zhao‐Peng , Li Xun 
Published: February 2022

AbstractThe epigenetic reader BRD4 is involved in chromatin remodelling and transcriptional regulation, making it a promising therapeutic target. However, over the past decades, many BRD4 inhibitors that entered clinical trials were, in the main, unsatisfactory, due to some therapeutic limitations such as off‐target effects and drug resistance. Combining a BRD4 inhibitor with another drug was expected to be an ideal option to overcome these hurdles and to improve therapeutic outcomes. However, such combination therapy could trigger toxicity caused by drug‐drug interactions, complex pharmacokinetics, and additive effects. Recently, the application of dual‐target drugs targeting BRD4 and other kinases has become an attractive approach to remedy the defects of a single BRD4 inhibitor. This review focuses on recent advances in the discovery of dual BRD4‐kinase inhibitors, with an emphasis on their co‐crystal structures and structure‐activity relationships (SARs), as well as future perspectives in this field.
Sulfurized Steel Nanoparticles: A Degradative Byproduct of ZrS2CVD with Promising Fenton‐Type Catalytic Activity
Authors: Currie Taylor M. , Narkar Ameya R. , Rudawski Nicholas G. , Bryant Jacob T. , Uribe‐Romo Fernando J. , Shultz Lorianne R. , Jurca Titel 
Published: February 2022

AbstractChemical vapor deposition (CVD), is an attractive method for the growth of two‐dimensional (2D) materials such as transition metal dichalcogenides (TMDCs). However, it is an inherently wasteful process; the majority of chemical precursors end up in the waste stream and their corrosive nature deteriorates reactor components. While exploring the thermal CVD growth of ZrS2, the resulting corrosion build up on the downstream stainless‐steel (SS) reactor components was collected and studied. Characterization of this material confirmed the presence of nanoplates composed of evenly distributed elements that constitute SS along with Cl, S, and trace Zr from the precursors. The material proved remarkably active as a photo‐Fenton type catalyst for the aqueous degradation of methylene blue. Harvesting and upcycling this overlooked nanomaterial will reduce waste and concomitantly add value and enhance the sustainability of the overall TMDC fabrication process.
An optimal asthma disease detection technique for voice signal using hybrid machine learning technique
Authors: Asim Iqbal Mohammed , Devarajan Krishnamoorthy , Ahmed Syed Musthak 
Published: February 2022

AbstractCurrent clinical practice in the treatment of chronic respiratory diseases does not have an effective method that allows patients and caregivers to constantly monitor the severity of respiratory symptoms. This is the “asthma breath” that occurs in the respiratory tract. In this article, we propose an optimal asthma disease detection technique for voice signal using hybrid machine learning (OADD‐HML) technique. In OADD‐HML technique, we used the improved weed optimization (IWO) algorithm for asthma detection and forecasting. We analyze whether the scattered signal pattern follows the frequency of normal and abnormal breathing sounds. Second, we illustrate an enhanced hunting search (EHS) algorithm for feature extraction and selection process. Then, deep Q neural network (DQNN) classifier used to identify the asthma, crackle, and normal speech. After performing the function recovery and classification using DQNN, the respiratory number classes will be identified. The test results show several classifications of specific OADD‐HML breathing sounds, respectively, using accuracy, sensitivity, and specificity. Comparison results of asthma and non‐asthma classification of respiratory sounds suggest that the particular method works better than usual existing state‐of‐art.
On the Sensitivity to Density‐Functional Approximations for CO Binding Energies of Single‐Atom Catalysts in Nitrogen‐Doped Graphene
Authors: Wu Qin , Wang Guangjin , Liu Mingjie 
Published: February 2022

AbstractDensity functional theory (DFT) methods are the working horse in screening new catalytic materials. They are widely used to predict trends in binding energies, which are then used to compare the activity of different materials. The binding strength of CO is an important descriptor to the CO2 reduction catalytic activity of the single transition metal atoms embedded on nitrogen‐doped graphene (TM/NG). In this work, however, we show that CO binding strengths in different TM/NG has very different sensitivity to DFT methods. Specifically, Fe/NG CO binding energy changes dramatically with the percentage of exact exchange in the functional; Co/NG does less so, while Ni/NG nearly has no change. Such varying behaviors is a direct result of different local spin configurations, similar to the performance of DFT methods for metal porphyrin complexes. Therefore, caution should be exercised when using DFT binding energies for quantitative predictions in TM/NG single atom catalysis.