bluuebunny/crossref_metadata_2025_split huggingface dataset:
Possible strategies for use of artificial intelligence in screen-reading of mammograms, based on retrospective data from 122,969 screening examinations
Authors: Larsen Marthe , Aglen Camilla F. , Hoff Solveig R. , Lund-Hanssen Håkon , Hofvind Solveig 
Published: June 2022

Abstract
Objectives
Artificial intelligence (AI) has shown promising results when used on retrospective data from mammographic screening. However, few studies have explored the possible consequences of different strategies for combining AI and radiologists in screen-reading.

Methods
A total of 122,969 digital screening examinations performed between 2009 and 2018 in BreastScreen Norway were retrospectively processed by an AI system, which scored the examinations from 1 to 10; 1 indicated low suspicion of malignancy and 10 high suspicion. Results were merged with information about screening outcome and used to explore consensus, recall, and cancer detection for 11 different scenarios of combining AI and radiologists.

Results
Recall was 3.2%, screen-detected cancer 0.61% and interval cancer 0.17% after independent double reading and served as reference values. In a scenario where examinations with AI scores 1–5 were considered negative and 6–10 resulted in standard independent double reading, the estimated recall was 2.6% and screen-detected cancer 0.60%. When scores 1–9 were considered negative and score 10 double read, recall was 1.2% and screen-detected cancer 0.53%. In these two scenarios, potential rates of screen-detected cancer could be up to 0.63% and 0.56%, if the interval cancers selected for consensus were detected at screening. In the former scenario, screen-reading volume would be reduced by 50%, while the latter would reduce the volume by 90%.

Conclusion
Several theoretical scenarios with AI and radiologists have the potential to reduce the volume in screen-reading without affecting cancer detection substantially. Possible influence on recall and interval cancers must be evaluated in prospective studies.

Key Points
• Different scenarios using artificial intelligence in combination with radiologists could reduce the screen-reading volume by 50% and result in a rate of screen-detected cancer ranging from 0.59% to 0.60%, compared to 0.61% after standard independent double reading
• The use of artificial intelligence in combination with radiologists has the potential to identify negative screening examinations with high precision in mammographic screening and to reduce the rate of interval cancer
DHA status influences effects of B-vitamin supplementation on cognitive ageing: a post-hoc analysis of the B-proof trial
Authors: van Soest Annick P. M. , van de Rest Ondine , Witkamp Renger F. , Cederholm Tommy , de Groot Lisette C. P. G. M. 
Published: June 2022

Abstract
Purpose
Trials aiming to lower homocysteine by B-vitamin supplementation have reported mixed results on slowing cognitive decline. We investigated if efficacy of B-vitamin supplementation is affected by baseline plasma omega-3 fatty acid levels.

Methods
This post-hoc analysis of the B-proof trial included 191 adults aged 65 years or older with baseline plasma total homocysteine ≥ 12 μmol/L, randomly assigned to 400 µg folic acid and 500 µg vitamin B12 or placebo daily for 2 years. Global and domain-specific cognitive functioning were assessed at baseline and after 2 years. The effect of B-vitamin supplementation was analyzed according to tertiles of baseline plasma omega-3 fatty acids concentrations combined, and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) individually using multiple linear regression analyses.

Results
The mean ± SD age of the participants was 71.6 ± 5.9 years and median [IQR] Mini-Mental State Examination was 29 [28–30]. The treatment effect of B-vitamins on global cognition was larger in participants in the high compared to the middle DHA tertile (difference in z-score, mean ± SE 0.22 ± 0.10, p = 0.03). There was no significant interaction between B-vitamin supplementation and combined omega-3 fatty acid (p = 0.49) and EPA (p = 0.99) tertiles. Similarly, the efficacy of B-vitamin treatment on domain-specific cognitive functioning did not link to omega-3 fatty acid, DHA, or EPA plasma levels.

Conclusion
This post-hoc analysis indicated that efficacy of B-vitamin supplementation in slowing cognitive decline relates to DHA status, with individuals with higher plasma DHA levels benefitting more from vitamin B12 and folic acid use. The results support earlier observations that positive effects of B-vitamins in cognitive ageing may be subgroup-specific.
Trial registration: Registered at clinicaltrials.gov (NCT00696514) on June 12, 2008.
Presurgical video-EEG monitoring with foramen ovale and epidural peg electrodes: a 25-year perspective
Authors: Miron Gadi , Dehnicke Christoph , Meencke Heinz-Joachim , Onken Julia , Holtkamp Martin 
Published: June 2022

Abstract
Background
Epilepsy surgery cases are becoming more complex and increasingly require invasive video-EEG monitoring (VEM) with intracranial subdural or intracerebral electrodes, exposing patients to substantial risks. We assessed the utility and safety of using foramen ovale (FO) and epidural peg electrodes (FOP) as a next step diagnostic approach following scalp VEM.

Methods
We analyzed clinical, electrophysiological, and imaging characteristics of 180 consecutive patients that underwent FOP VEM between 1996 and 2021. Multivariate logistic regression was used to assess predictors of clinical and electrophysiological outcomes.

Results
FOP VEM allowed for immediate resection recommendation in 36 patients (20.0%) and excluded this option in 85 (47.2%). Fifty-nine (32.8%) patients required additional invasive EEG investigations; however, only eight with bilateral recordings. FOP VEM identified the ictal onset in 137 patients, compared to 96 during prior scalp VEM, p = .004. Predictors for determination of ictal onset were temporal lobe epilepsy (OR 2.9, p = .03) and lesional imaging (OR 3.1, p = .01). Predictors for surgery recommendation were temporal lobe epilepsy (OR 6.8, p < .001), FO seizure onset (OR 6.1, p = .002), and unilateral interictal epileptic activity (OR 3.8, p = .02). One-year postsurgical seizure freedom (53.3% of patients) was predicted by FO ictal onset (OR 5.8, p = .01). Two patients experienced intracerebral bleeding without persisting neurologic sequelae.

Conclusion
FOP VEM adds clinically significant electrophysiological information leading to treatment decisions in two-thirds of cases with a good benefit–risk profile. Predictors identified for electrophysiological and clinical outcome can assist in optimally selecting patients for this safe diagnostic approach.
Semi-uniform input-to-state stability of infinite-dimensional systems
Authors: Wakaiki Masashi 
Published: June 2022

AbstractWe introduce the notions of semi-uniform input-to-state stability and its subclass, polynomial input-to-state stability, for infinite-dimensional systems. We establish a characterization of semi-uniform input-to-state stability based on attractivity properties as in the uniform case. Sufficient conditions for linear systems to be polynomially input-to-state stable are provided, which restrict the range of the input operator depending on the rate of polynomial decay of the product of the semigroup and the resolvent of its generator. We also show that a class of bilinear systems are polynomially integral input-to-state stable under a certain smoothness assumption on nonlinear operators.
Using three scenarios to explain life expectancy in advanced cancer: attitudes of patients, family members, and other healthcare professionals
Authors: Nahm Sharon H. , Stockler Martin R. , Martin Andrew J. , Grimison Peter , Fox Peter , Zielinski Rob , Hawson Geoffrey AT. , Tattersall Martin HN. , Kiely Belinda E. 
Published: June 2022

Abstract

Aim
To evaluate a web-based tool for estimating and explaining three scenarios for expected survival time to people with advanced cancer (patients), their family members (FMs), and other healthcare professionals (HCPs).

Methods
Thirty-three oncologists estimated the “median survival of a group of similar patients” for patients seeking quantitative prognostic information. The web-based tool generated worst-case, most likely, and best-case scenarios for survival based on the oncologist’s estimate. Oncologists presented the scenarios to each patient and provided a printed summary to patients, FMs, and HCPs. Attitudes to the information were assessed by questionnaires. Observed survival for each patient was compared with the oncologist’s estimated survival and the three scenarios.

Results
Prognosis was discussed with 222 patients: median age 67 years; 61% male; most common primary sites pancreas 15%, non-small-cell lung 15%, and colorectal 12%. The median (range) for observed survival times was 9 months (0.5–43) and for oncologist’s estimated survival times was 12 months (2–96). Ninety-one percent of patients, 91% of FMs, and 84% of HCPs agreed that it was helpful having life expectancy explained as three scenarios. The majority (77%) of patients judged the information presented about their life expectancy to be the same or better than they had expected before the consultation. The survival estimates met a priori criteria for calibration, precision, and accuracy.

Conclusions
Patients, FMs, and HCPs found it helpful to receive personalized prognostic information formatted as three scenarios for survival. It was feasible, acceptable, and safe to use a web-based resource to do this.
Screening of orange peel waste on valuable compounds by gradient multiple development diode-array high-performance thin-layer chromatography
Authors: Spangenberg Bernd , Seigel Andrea , Brämer Regina 
Published: June 2022

AbstractHigh-performance thin-layer chromatography (HPTLC), as the modern form of TLC (thin-layer chromatography), is suitable for detecting pharmaceutically active compounds over a wide polarity range using the gradient multiple development (GMD) technique. Diode-array detection (DAD) in conjunction with HPTLC can simultaneously acquire ultraviolet‒visible (UV‒VIS) and fluorescence spectra directly from the plate. Visualization as a contour plot helps to identify separated zones. An orange peel extract is used as an example to show how GMD‒DAD‒HPTLC in seven different developments with seven different solvents can provide an overview of the entire sample. More than 50 compounds in the extract can be separated on a 6-cm HPTLC plate. Such separations take place in the biologically inert stationary phase of HPTLC, making it a suitable method for effect-directed analysis (EDA). HPTLC‒EDA can even be performed with living organism, as confirmed by the use of Aliivibrio fischeri bacteria to detect bioluminescence as a measure of toxicity. The combining of gradient multiple development planar chromatography with diode-array detection and effect-directed analysis (GMD‒DAD‒HPTLC‒EDA) in conjunction with specific staining methods and time-of-flight mass spectrometry (TOF‒MS) will be the method of choice to find new chemical structures from plant extracts that can serve as the basic structure for new pharmaceutically active compounds.
Validity and reliability of the Arabic version of the Self-Efficacy for Managing Chronic Disease scale in rheumatoid arthritis patients
Authors: Sarhan Shymaa A. , Kamal Doaa E. , Hamed Mona S. , Mostafa Dalia I. 
Published: June 2022

AbstractBackground and objectivesRheumatoid arthritis (RA) is an autoimmune inflammatory condition that causing disability and affection of patient’s quality of life (QoL). Self-efficacy investigation helps us to detect the requirements of chronically affected patients and evaluation of self-care management programs. The aim of our study was to test validity and reliability of Self-Efficacy for Managing Chronic Disease (SEMCD-Arabic) in RA patients.MethodThis study included 248 RA patients, carried out at Rheumatology and Rehabilitation Department. The SEMCD-Arabic Validity was assessed by correlating the SEMCD-Arabic scale with the validated Arabic version of the modified Health Assessment Questionnaire HAQ (MHAQ), the Arabic version of the Multidimensional Assessment of Fatigue (MAF) scale, and the Arabic version of Short Form 36 version 2 for quality of life (SF QoL). Internal consistency, test–retest reliability was assessed.ResultsConvergent validity was confirmed by a positive correlation between (physical, mental) component of SF QoL and SEMCD-Arabic (r = 0.918,r = 0.925) respectively, and negative correlation between MAF and SEMCD-Arabic (r =  − 0.657) and MHAQ with SEMCD-Arabic (r =  − 0.595). Discriminant validity confirmed by a significant negative correlation between visual analogue scale (VAS) for pain, disease activity scale (DAS28), Morning stiffness, patient health, physician health, age, duration, and SEMCD-Arabic (r =  − 0.1–0.7) (P < 0.001). Test–retest reliability was estimated which revealed a high interclass correlation coefficient (ICC = 0.87–0.997) indicating excellent agreement and internal consistency is acceptable as the Cronbach’s alpha value (0.660 to 0.78).ConclusionThe SEMCD-Arabic questionnaire can be used as a valid and reliable measure for assessment of patient’s self-efficacy in RA.Key Points• The SEMCD-Arabic questionnaire has a statistically significant validity in correlation with different clinical manifestations MHAQ, SF QoL, and MAF.• The Arabic SEMCD is highly reliable with a Cronbach’s alpha of 0.660 to 0.78.
Constraint-evading surrogacy: the missing piece in Radical Embodied Cognition’s non-representationalist account of intentionality?
Authors: Robinson Andrew , Southgate Christopher 
Published: June 2022

AbstractRadical Embodied Cognition (REC) is an anti-representationalist approach to the nature of basic cognition proposed by Daniel Hutto and Erik Myin. While endorsing REC’s arguments against a role for contentful representations in basic cognition we suggest that REC’s ‘teleosemiotic’ approach to intentional targeting results in a ‘grey area’ in which it is not clear what kind of causal-explanatory concept is involved. We propose the concept of constraint-evading surrogacy as a conceptual basis for REC’s account of intentional targeting. The argument is developed via a reconsideration of Peter Godfrey-Smith’s ‘environmental complexity thesis’. We show how constraint-evading surrogacy clarifies REC’s account of intentionality by specifying the role of external natural signs and certain internal states (REC’s ‘Local Indexical Guides’). We argue that the resulting view of intentionality can be extended to proto-biotic autocatalytic systems, offering support for the life-mind continuity thesis. We leave open the question of whether it is helpful to consider constraint-evading surrogacy to be a form of (non-contentful) representation, but we suggest that there is a prima facie case for such a view.
Aerosol mass and size-resolved metal content in urban Bangkok, Thailand
Authors: Matthews James C. , Navasumrit Panida , Wright Matthew D. , Chaisatra Krittinee , Chompoobut Chalida , Arbon Robert , Khan M. Anwar H. , Ruchirawat Mathuros , Shallcross Dudley E. 
Published: June 2022

AbstractInhalable particulate matter (PM) is a health concern, and people living in large cities such as Bangkok are exposed to high concentrations. This exposure has been linked to respiratory and cardiac diseases and cancers of the lung and brain. Throughout 2018, PM was measured in northern Bangkok near a toll road (13.87°N, 100.58°E) covering all three seasons (cool, hot and rainy). PM10 was measured in 24- and 72-h samples. On selected dates aerodynamic size and mass distribution were measured as 3-day samples from a fixed 5th floor inlet. Particle number concentration was measured from the 5th floor inlet and in roadside survey measurements. There was a large fraction of particle number concentration in the sub-micron range, which showed the greatest variability compared with larger fractions. Metals associated with combustion sources were most found on the smaller size fraction of particles, which may have implications for associated adverse health outcomes because of the likely location of aerosol deposition in the distal airways of the lung. PM10 samples varied between 30 and 100 μg m−3, with highest concentrations in the cool season. The largest metal fractions present in the PM10 measurements were calcium, iron and magnesium during the hot season with average airborne concentrations of 13.2, 3.6 and 2.0 μg m−3, respectively. Copper, zinc, arsenic, selenium, molybdenum, cadmium, antimony and lead had large non-crustal sources. Principal component analysis (PCA) identified likely sources of the metals as crustal minerals, tailpipe exhaust and non-combustion traffic. A health risk analysis showed a higher risk of both carcinogenic and non-carcinogenic health effects in the drier seasons than the wet season due to ingestion of nickel, arsenic, cadmium and lead.
Graphical abstract
The EPINetz Twitter Politicians Dataset 2021. A New Resource for the Study of the German Twittersphere and Its Application for the 2021 Federal Elections
Authors: König Tim , Schünemann Wolf J. , Brand Alexander , Freyberg Julian , Gertz Michael 
Published: June 2022

AbstractThis research note introduces the EPINetz Twitter Politicians Dataset, a comprehensive dataset of 2449 Twitter accounts of German parliamentarians, minsters, state secretaries, parties, and ministries on a state, federal, and European Union level for the year 2021. This hand-curated dataset not only provides up-to-date information on elected officials, but it also includes additional variables such as their party affiliation, age, and gender. Furthermore, it provides linkages to additional data sources by providing the accounts’ Wikidata and Abgeordnetenwatch (Parliamentwatch) IDs. While it does not provide actual tweet data, the dataset will be a valuable resource for researchers by providing easy access to elected German politicians. We demonstrate some of the dataset’s uses with an analysis of the 2021 German Federal Elections. The full dataset can be accessed via https://doi.org/10.7802/2415.
Covariant constancy of quantum Steenrod operations
Authors: Seidel Paul , Wilkins Nicholas 
Published: June 2022

AbstractWe prove a relationship between quantum Steenrod operations and the quantum connection. In particular, there are operations extending the quantum Steenrod power operations that, when viewed as endomorphisms of equivariant quantum cohomology, are covariantly constant. We demonstrate how this property is used in computations of examples.
Supporting family carers in Ireland: the role of the general practitioner
Authors: Cronin Mary , McGilloway Sinead 
Published: June 2022

Abstract
Background

Ireland has over half a million family carers who provide care to a family member or loved one. Internationally, it is recognised that general practitioners (GPs) have a critical role to play in the identification and support of family carers, but, to date, no guidelines exist in Ireland to support GPs in this role.

Aims
The aim of this study was to examine how carers are currently supported (or not) by healthcare professionals in Ireland, with a particular focus on the role of the GP.

Methods
A mixed method design was used, involving a national online survey (N = 132) of family carers in Ireland and one-to-one interviews with 10 stakeholders (4 GPs; 6 carers). The quantitative data were analysed using a series of descriptive and inferential statistics; the interview data were analysed using framework analysis.

Results
Sixty-one per cent of the carer sample reported experiencing psychological distress, more than two-thirds of whom (69%) reported ‘rarely’ or ‘never’ being asked about their own health and wellbeing. Sixty-one per cent also felt misunderstood in terms of the challenges they face in their caring role. Three key themes were identified from the interview data including (1) GP role ambiguity; (2) navigating informal processes and (3) changing needs along the care trajectory.

Conclusions
The findings suggest important gaps in terms of the role of GPs vis-à-vis their support of family carers. GPs themselves indicated that they need both greater clarity regarding their role with family carers and more training and resources in this regard. A requirement for more streamlined communication and information provision was also highlighted by both GPs and carers. Carers reported a need for more information on the role of GPs in supporting carers as well as more support in addressing, in particular, the psychological complexities of carer identity and help seeking.
Police Dyads Within an Operational Simulation: an Empirical Test of the Research Propositions Made in the “Big Five” Teamwork Approach
Authors: Espevik Roar , Johnsen Bjørn Helge , Hystad Sigurd W. 
Published: June 2022

AbstractBased on the impact of the theoretical big five of teamwork model proposed by Salas et al. (2005), the present study aimed at investigating the model within an operational police simulation. One hundred and sixty-seven frontline police officers participated in the study. Based on path analyses, a reduced model excluding trust and leadership obtained a good fit with the data.The results provided some support for the model by confirming six out of 10 proposed direct effects and four out of seven indirect pathways. Shared mental models directly affected team adaptability, and backup behavior affects adaptability and team effectiveness. Team orientation affects mutual performance monitoring and backup behavior, and finally, reciprocal monitoring affects backup behavior. Monitoring influenced both team effectiveness and adaptability through backup behavior. Two paths from team orientation towards effectiveness were found. One flowing through monitoring and another through back-up behavior. Our study expands former knowledge of the big five theory by empirically testing the totality of the model and identifying important pathways.
Hyperkalaemia in Heart Failure: Consequences for Outcome and Sequencing of Therapy
Authors: Murphy Daniel , Banerjee Debasish 
Published: June 2022

Abstract
Purpose of Review

Heart failure (HF), in conjunction with common comorbidities such as chronic kidney disease and diabetes and medical therapies such as RAASi, predisposes to hyperkalaemia which may lead to hospitalisation and death. This paper aims to review the most current evidence surrounding the risks and management of hyperkalaemia in HF, with particular focus on recent research into RAASi including novel selective mineralocorticoid receptor blockers and novel potassium binders.

Recent Findings
The most recent evidence shows that even moderate hyperkalaemia may predispose to adverse outcomes such as hospitalisation and death. Furthermore, it may prevent patients from receiving optimal medical therapy for HF by reducing prescription of RAASi therapy. Novel potassium binders such as sodium zirconium cyclosilicate (SZC) and patiromer present potential options to reduce and prevent hyperkalaemia as well as maintain optimal RAASi dosing in HF.

Summary
Management of hyperkalaemia in HF has advanced in recent years. New therapies such as SZC and patiromer are contributing to the management of acute hyperkalaemia and also access to life-saving RAASi therapies by tackling and preventing hyperkalaemia in the community.