bluuebunny/crossref_metadata_2025_split huggingface dataset:
Small Molecule‐Induced Differentiation As a Potential Therapy for Liver Cancer
Authors: Zhang Xu , Zhu Xiang‐Jie , Zhong Zhi , Du Jiang‐Chuan , Fang Guo‐Xu , Cui Xiu‐liang , Guan Ling‐Ting , Hu Yan‐Yu , Wang Hong‐Yang , Zhang Pei‐Lin 
Published: March 2022

AbstractDespite the efficacy demonstrated by immunotherapy recently, liver cancer still remains one of the deadliest cancers, mainly due to heterogeneity of this disease. Continuous exploration of new therapeutics is therefore necessary. Chemical‐induced cell differentiation can serve as a promising approach, with its ability to consistently remodel gene expression profile and alter cell fate. Inspired by advances in stem cell and reprogramming field, here it is reported that a small molecule cocktail (SMC) consisted of: SB431542 (TGFβ inhibitor), CHIR99021 (GSK3β inhibitor), BIX01294 (H3K9 methyltransferase/G9a inhibitor), and all‐trans retinoic acid (ATRA), can induce differentiation of liver cancer cells including cell lines, primary cancer cells, cancer stem cells, and drug resistant cells. Treated cells lose malignant characteristics and regain hepatocyte phenotype instead. When applied in vivo, SMC induces wide range of tissue necrosis or fibrosis within the tumors, while remaining tissues begin to express hepatic nuclear factor 4α (HNF4α), the hepatic nuclear marker. SMC also leads to tumor abrogation in orthotopic xenograft models and life span extension of animals. The powerful differentiation induction of SMC is exerted through modulation of Akt/mTOR/HIF1α signaling and metabolic reprogramming, as well as suppressing Snail and enhancing HNF4α expression. Together, these results highlight that chemical‐induced differentiation has the potential to effectively treat liver cancer disregard of heterogeneity.
Simple and Scalable Chemical Surface Patterning via Direct Deposition from Immobilized Plasma Filaments in a Dielectric Barrier Discharge
Authors: Demaude Annaëlle , Baert Kitty , Petitjean David , Zveny Juliette , Goormaghtigh Erik , Hauffman Tom , Gordon Michael J. , Reniers François 
Published: March 2022

AbstractIn this work, immobilization of the often unwanted filaments in dielectric barrier discharges (DBD) is achieved and used for one‐step deposition of patterned coatings. By texturing one of the dielectric surfaces, a discharge containing stationary plasma filaments is ignited in a mix of argon and propargyl methacrylate (PMA) in a reactor operating at atmospheric pressure. From PMA, hydrophobic and hydrophilic chemical and topographical contrasts at sub‐millimeter scale are obtained on silicon and glass substrates. Chemical and physical characterizations of the samples are performed by micrometer‐scale X‐ray photoelectron spectroscopy and infrared imaging and by water contact angle and profilometry, respectively. From the latter and additional information from high‐speed imaging of the plasma phase and electrical measurements, it is suggested that filaments, denser in energetic species, lead to higher deposition rate with higher fragmentation of the precursor, while surface discharges igniting outwards the filaments are leading to smoother and slower deposition. This work opens a new route for a one‐step large‐area chemical and morphological patterning of surfaces at sub‐millimeter scales. Moreover, the possibility to separately deposit coatings from filaments and the surrounding plasma phase can be helpful to better understand the processes occurring during plasma polymerization in filamentary DBD.
Thermally Activated Delayed Fluorescent Gain Materials: Harvesting Triplet Excitons for Lasing
Authors: Yan Chang‐Cun , Wang Xue‐Dong , Liao Liang‐Sheng 
Published: March 2022

AbstractThermally activated delayed fluorescent (TADF) materials have attracted increasing attention because of their ability to harvest triplet excitons via a reverse intersystem crossing process. TADF gain materials that can recycle triplet excitons for stimulated emission are considered for solving the triplet accumulation problem in electrically pumped organic solid‐state lasers (OSSLs). In this mini review, recent progress in TADF gain materials is summarized, and design principles are extracted from existing reports. The construction methods of resonators based on TADF gain materials are also introduced, and the challenges and perspectives for the future development of TADF gain materials are presented. It is hoped that this review will aid the advances in TADF gain materials and thus promote the development of electrically pumped OSSLs.
Degradable Pseudo Conjugated Polymer Nanoparticles with NIR‐II Photothermal Effect and Cationic Quaternary Phosphonium Structural Bacteriostasis for Anti‐Infection Therapy
Authors: Zhou Huiling , Tang Dongsheng , Kang Xiaoxu , Yuan Haitao , Yu Yingjie , Xiong Xiaolu , Wu Nier , Chen Fangzhou , Wang Xing , Xiao Haihua , Zhou Dongsheng 
Published: March 2022

AbstractPhotothermal therapy based on conjugated polymers represents a promising antibacterial strategy but still possesses notable limitations. Herein, degradable pseudo conjugated polymers (PCPs) containing photothermal molecular backbones and reactive oxygen species (ROS)‐sensitive thioketal bonds are designed. Triphenylphosphine (PPh3) is introduced into PCPs to generate phosphonium‐based PCPs (pPCPs), which further assembled with hyaluronic acid into pPCP nanoparticles (pPCP‐NPs). pPCP‐NPs with quaternary phosphonium cations selectively anchor on and destroy bacterial cell membranes through electrostatic action. Under 1064 nm laser irradiation, pPCP‐NPs (pPCP‐NPs/+L) produce near‐infrared‐II (NIR‐II) photothermal antibacterial effect, thereby killing bacteria in a sustained manner. pPCP‐NPs are readily degraded upon ROS abundant at infection sites, therefore exhibiting enough biosafety. pPCP‐NPs/+L display an almost 100% bacterial inhibition rate in vitro and resultin a nearly complete recovery of bacteria‐induced mouse wounds. A further metabolomics analysis denotes that pPCP‐NPs/+L work in a concerted way to induce bacterial DNA damage, inhibit bacterial carbon/nitrogen utilization and amino acid/nucleotide synthesis. Taken together, degradable pPCP‐NPs with both NIR‐II photothermal effect and cationic phosphonium structural bacteriostasis provide a new avenue for antibiotics‐alternative anti‐infection therapy.
Structural Reconstruction Driven by Oxygen Vacancies in Layered Ni‐Rich Cathodes
Authors: Qiu Lang , Song Yang , Zhang Mengke , Liu Yihua , Yang Zhiwei , Wu Zhenguo , Zhang Heng , Xiang Wei , Liu Yuxia , Wang Gongke , Sun Yan , Zhang Jun , Zhang Bin , Guo Xiaodong 
Published: March 2022

AbstractStructure reconstruction induced by the migration of Li, O, and transition metal (TM) ions plays a key role in the performance of Ni‐based cathodes, yet their interactions are still poorly understood. This work investigates systematically the structure transformation of the high‐temperature lithiation in air and oxygen rich atmosphere, charging process, and long‐term storage. Structural and electrochemical characterization of Li‐free/Li‐containing phases (Ni0.92Co0.04Mn0.04(OH)2 and LixNi0.92Co0.04Mn0.04Oy) and a series of detailed analyses provide an in‐depth understanding of the structural reconstruction induced by the interaction of Li, O, and TM ions, i.e., the shift of Li/TM ions in the lattice leads to structural reconstruction via a layered structure with oxygen vacancies.
Sequencing of Uniform Multifunctional Oligoesters via Random Chain Cleavages
Authors: Soete Matthieu , Du Prez Filip E. 
Published: March 2022

AbstractSequence‐defined polymers have been the object of many fascinating studies that focus on their implementation in both material and life science applications. In parallel, iterative synthetic methodologies have become more efficient, whereas the structure elucidation of these molecules is generally dependent on MS/MS analysis. Here, we report an alternative, simple strategy for the determination of the monomer order of uniform oligo(thioether ester)s. This approach, which relies on random cleavages of ester units within the macromolecular backbone via a basic treatment, enables the swift characterization of these macromolecules without the need for MS/MS. Consequently, this method can be used for decoding any information stored within the primary structure of oligoesters by means of ESI‐ or LC–MS. Finally, we speculate that a range of structurally diverse backbones could be susceptible towards this approach, which could promptly expand the library of chemically sequenceable macromolecules.
Intermolecular Carbosilylation of α‐Olefins with C(sp3)−C(sp) Bond Formation Involving Silylium‐Ion Regeneration
Authors: He Tao , Qu Zheng‐Wang , Klare Hendrik F. T. , Grimme Stefan , Oestreich Martin 
Published: March 2022

AbstractA regioselective addition of alkynylsilanes across unactivated, terminal alkenes is reported. The reaction is initiated by the capture of a sterically unhindered silylium ion by a silylated phenylacetylene derivative to form a bis(silylated) ketene‐like carbocation. This in situ‐generated key intermediate is the actual catalyst that maintains the catalytic cycle by a series of electrophilic addition reactions of silylium ions and β‐silicon‐stabilized carbocations. The computed reaction mechanism is fully consistent with the experimental findings. This unprecedented two‐component carbosilylation establishes a C(sp3)−C(sp) bond and a C(sp3)−Si bond in atom‐economic fashion.
Nanofibrous electroconductive nerve guide conduits based on polyaniline‐co‐polydopamine random copolymer for peripheral nerve regeneration
Authors: Moosaipour Majid , Pakinia Simin , Izadi Zhila , Khalilzadeh Balal , Jaymand Mehdi , Samadian Hadi 
Published: March 2022

AbstractThe main aim of the current study was to fabricate bio‐ and electro‐active electrospun nanofibrous neural conduits for peripheral nerve regeneration. At first, polyaniline‐co‐polydopamine (PANI‐co‐PDA) random copolymer was synthesized using a chemical oxidation polymerization method. The synthesized copolymer was blended with poly(vinyl alcohol) (PVA) and used for the electrospinning to afford nanofibrous neural conduits. The characterization showed that the fabricated nanofibers have a diameter in the range of 500–600 nm, and the incorporation of PANI‐co‐PDA slightly reduced the hydrophilicity, water absorption capacity, while the electrical conductivity and mechanical properties were increased. The in vitro studies revealed the biodegradability (evaluated using weight loss and morphology study), hemocompatibility (assessed using hemolysis measurement), and biocompatibility (investigated using MTT assay kit) of the fabricated nanofibers. Moreover, the assembled homemade conduit fabricating electrospinning setup resulted in a conduit with proper dimensions, 2 mm in diameter and 2 cm in length. It was found that the fabricated nanofibrous conduits confer proper biological, mechanical, and electrical properties and can be applied as the peripheral nerve regenerating construct.
Harmonic control of a dual‐valve hydraulic servo system with dynamically allocated flows
Authors: Su Shijie , Xue Ting , Chen Yun , Yang Hui 
Published: March 2022

AbstractModern industries face increasing demands to improve the precision and workability of equipment, leading to stringent requirements for hydraulic servo systems in terms of flow, accuracy, and output power. High‐flow servo valves and multi‐valve synchronous control methods have seen more applications in the industry to meet these demands. However, high‐flow servo valves are expensive and have unsatisfactory performance, and synchronous control methods require servo valves to have the same hydraulic characteristics, resulting in higher cost and lower accuracy of high‐flow hydraulic servo systems. Also, very little has been conducted on controlling single actuators using multiple valves. In this study, we design a novel dual‐valve hydraulic servo system structure with a high‐flow proportional directional valve that is connected in parallel with a low‐flow servo valve and further develop the mathematical model of this dual‐valve system. Next, a harmonic control scheme was proposed, which included a flow allocation layer and trajectory tracking layer. Thereby, we achieved optimal control of two valves, and robust performance was guaranteed. Finally, we investigate the relationships between the flows of two valves, the deadband of the proportional directional valve, and trajectory tracking errors. Experimental results show that the proposed control scheme can effectively adjust the output flow of each valve dynamically according to the tracking trajectory and the hydraulic characteristics of the two valves, and the tracking performance of the servo system is significantly improved. This method is promised to enable the realization of an economical, high‐flow, high‐precision hydraulic servo system that can be generally used in various fields, such as marine engineering and construction.
Hybridization of nickel oxide nanoparticles with carbon dots and its application for antibacterial activities
Authors: Nemera Dugasa Jabesa , Etefa Habtamu Fekadu , Kumar Vinod , Dejene Francis Birhanu 
Published: March 2022

AbstractA nickel oxide nanoparticle (NiO NP) composite with carbon dots (C‐dots), (NiO NPs@C‐dots) was synthesized, characterized, and then its antibacterial activity was evaluated. NiO NPs were prepared using Buddleja polystachya Fresen leaf extract and Ni(NO3)2.6H2O as precursors. The C‐dots were synthesized from benzene‐1,4‐diamine and citric acid. The cubic structure of the NiO NPs and NiO NPs@C‐dots was in phase with their average particle size distributions of 21.47 ± 0.56 and 21.61 ± 0.34 nm, respectively. The surface morphology of the NiO NPs@C‐dots was characterized using field emission scanning electron microscopy and also revealed a large surface area, which is advantageous for the specified application. The X‐ray diffraction result indicated a cubic face wurtzite structure and the crystalline nature of the NiO NPs. Carbon‐doped compounds had no influence on the crystal structure of the NiO compound and no new peaks were observed. The antibacterial activity of a composite made up of NiO NPs@C‐dots was tested, as well as the antibacterial activities of compounds produced against human photogenic bacterial strains. Both NiO NPs and NiO NPs@C‐dots were found to be powerful against all bacterial strains, based on the bioassay results. NiO NPs and NiO@C‐dots appeared to display strong to inhibitory effects of 14–20 mm and 17–23 mm, respectively.
Difficulty in predicting intra‐abdominal adhesion before cesarean section: A case report
Authors: Suzuki Nanao , Wakaki Yu , Watanabe Kaori , Kumasaka Yukiko , Suzuki Rika 
Published: March 2022

AbstractSevere adhesions between the bladder and uterus necessitated an atypical incision in the cesarean section of a woman with endometriosis. This could not be predicted with pre‐surgery MRI. No methods in the literature are able to predict adhesions with true certainty; it is therefore still difficult to diagnose intra‐abdominal adhesions.
PRISMA2020: An R package and Shiny app for producing PRISMA 2020‐compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis
Authors: Haddaway Neal R. , Page Matthew J. , Pritchard Chris C. , McGuinness Luke A. 
Published: March 2022

AbstractBackgroundReporting standards, such as PRISMA aim to ensure that the methods and results of systematic reviews are described in sufficient detail to allow full transparency. Flow diagrams in evidence syntheses allow the reader to rapidly understand the core procedures used in a review and examine the attrition of irrelevant records throughout the review process. Recent research suggests that use of flow diagrams in systematic reviews is poor and of low quality and called for standardised templates to facilitate better reporting in flow diagrams. The increasing options for interactivity provided by the Internet gives us an opportunity to support easy‐to‐use evidence synthesis tools, and here we report on the development of a tool for the production of PRISMA 2020‐compliant systematic review flow diagrams.Methods and FindingsWe developed a free‐to‐use, Open Source R package and web‐based Shiny app to allow users to design PRISMA flow diagrams for their own systematic reviews. Our tool allows users to produce standardised visualisations that transparently document the methods and results of a systematic review process in a variety of formats. In addition, we provide the opportunity to produce interactive, web‐based flow diagrams (exported as HTML files), that allow readers to click on boxes of the diagram and navigate to further details on methods, results or data files. We provide an interactive example here; https://prisma-flowdiagram.github.io/.ConclusionsWe have developed a user‐friendly tool for producing PRISMA 2020‐compliant flow diagrams for users with coding experience and, importantly, for users without prior experience in coding by making use of Shiny (https://estech.shinyapps.io/prisma_flowdiagram/). This free‐to‐use tool will make it easier to produce clear and PRISMA 2020‐compliant systematic review flow diagrams. Significantly, users can also produce interactive flow diagrams for the first time, allowing readers of their reviews to smoothly and swiftly explore and navigate to further details of the methods and results of a review. We believe this tool will increase use of PRISMA flow diagrams, improve the compliance and quality of flow diagrams, and facilitate strong science communication of the methods and results of systematic reviews by making use of interactivity. We encourage the systematic review community to make use of the tool, and provide feedback to streamline and improve their usability and efficiency.
High‐Efficiency and Stable Zn−Na3V2(PO4)3 Aqueous Battery Enabled by Electrolyte‐Induced Interphasial Engineering
Authors: Guo Gaoli , Tan Xiaoping , Wang Kaidi , Zhang Huang 
Published: March 2022

AbstractAqueous zinc batteries have been regarded as a promising energy storage technology due to their high energy, high material abundance, low toxicity, and intrinsic safety. NASICON‐type materials have been proposed as efficient cathodes for rechargeable batteries, yet they suffer from fast degradation and low Coulombic efficiency in aqueous batteries. Here we demonstrate that a rationally designed aqueous electrolyte containing a supporting Na salt and polymer additive can efficiently suppress the water activity through hydrogen bonding and facilitate the anion involvement in interfacial reactions, thus enabling the stable operation of sodium superionic conductor (NASICON) cathodes in aqueous zinc batteries. As exemplified by a Na3V2(PO4)3 cathode, the cell with zinc metal anode exhibits high cycling Coulombic efficiencies (around 99.9 % in average) with a steady output voltage and capacity retention for 300 cycles. This work addresses the potential issues with NASICON‐type cathodes in aqueous zinc batteries and proposes an effective solution via fundamental interphasial chemistry to design efficient and sustainable aqueous electrolytes.
Ubiquitylation of cyclin C by HACE1 regulates cisplatin‐associated sensitivity in gastric cancer
Authors: Jiang Hong‐yue , Chen Ying‐ling , Xu Xing‐xing , Li Chuan‐yin , Chen Yun , Li Dong‐ping , Zeng Xiao‐qing , Gao Hong 
Published: March 2022

AbstractBackgroundCyclin C (CCNC) was reported to take part in regulating mitochondria‐derived oxidative stress under cisplatin stimulation. However, its effect in gastric cancer is unknown. This study aimed to investigate the role of cyclin C and its ubiquitylation in regulating cisplatin resistance in gastric cancer.MethodsThe interaction between HECT domain and ankyrin repeat‐containing E3 ubiquitin‐protein ligase 1 (HACE1) and cyclin C was investigated by GST pull‐down assay, co‐immunoprecipitation and ubiquitylation assay. Mitochondria‐derived oxidative stress was studied by MitoSOX Red assay, seahorse assay and mitochondrial membrane potential measurement. Cyclin C‐associated cisplatin resistance was studied in vivo via xenograft.ResultsHACE1 catalysed the ubiquitylation of cyclin C by adding Lys11‐linked ubiquitin chains when cyclin C translocates to cytoplasm induced by cisplatin treatment. The ubiquitin‐modified cyclin C then anchor at mitochondira, which induced mitochondrial fission and ROS synthesis. Depleting CCNC or mutation on the ubiquitylation sites decreased mitochondrial ROS production and reduced cell apoptosis under cisplatin treatment. Xenograft study showed that disrupting cyclin C ubiquitylation by HACE1 conferred impairing cell apoptosis response upon cisplatin administration.ConclusionsCyclin C is a newly identified substrate of HACE1 E3 ligase. HACE1‐mediated ubiquitylation of cyclin C sheds light on a better understanding of cisplatin‐associated resistance in gastric cancer patients. Ubiquitylation of cyclin C by HACE1 regulates cisplatin‐associated sensitivity in gastric cancer. With cisplatin‐induced nuclear–mitochondrial translocation of cyclin C, its ubiquitylation by HACE1 increased mitochondrial fission and mitochondrial‐derived oxidative stress, leading to cell apoptosis.
Men and women show partly distinct effects of physical activity on brain integrity
Authors: Gonneaud Julie , Moreau Ilana , Felisatti Francesca , Arenaza‐Urquijo Eider , Ourry Valentin , Touron Edelweiss , de la Sayette Vincent , Vivien Denis , Chételat Gaël 
Published: March 2022

AbstractIntroductionPhysical inactivity and female sex are independently associated with increased Alzheimer's disease (AD) lifetime risk. This study investigates the possible interactions between sex and physical activity on neuroimaging biomarkers.MethodsIn 134 cognitively unimpaired older adults (≥65 years, 82 women) from the Age‐Well randomized controlled trial (baseline data), we investigated the association between physical activity and multimodal neuroimaging (gray matter volume, glucose metabolism, perfusion, and amyloid burden), and how sex modulates these associations.ResultsThe anterior cingulate cortex volume was independently associated with sex and physical activity. Sex and physical activity interacted on perfusion and amyloid deposition in medial parietal regions, such that physical activity was related to perfusion only in women, and to amyloid burden only in men.DiscussionPhysical activity has both sex‐dependent and sex‐independent associations with brain integrity. Our findings highlight partly distinct reserve mechanisms in men and women, which might in turn influence their risk of AD.Highlights
Sex and physical activity have been linked to Alzheimer's disease (AD) progression.
The association of sex and physical activity with brain health is partly independent.
Different reserve mechanisms exist in men and women.