bluuebunny/crossref_metadata_2025_split huggingface dataset:
CFDA-AM staining to assess the metabolic activity of Giardia duodenalis cysts inactivated by chlorine, boiling and ultraviolet irradiation
Authors: Rodrigues da Cunha Maria Júlia , Souza Freitas Bárbara Luíza , Nasser Fava Natália de Melo , Sabogal-Paz Lyda Patricia 
Published: August 2022

Abstract
Giardia duodenalis is responsible for several waterborne gastrointestinal outbreaks worldwide. In addition to limitations presented by the main disinfection methods, assessing the inactivation efficiency of cysts after the treatment also poses challenges. Thus, this study aimed to use the 5-carboxyfluorescein diacetate acetoxymethyl ester (CFDA-AM) staining protocol to evaluate the viability of G. duodenalis cysts inactivated by different UV and chlorination doses and boiling times. Under epifluorescent microscopy, metabolically active cysts that presented green fluorescence were considered viable. In contrast, when no green fluorescence could be observed, organisms were considered non-viable. Although statistical analysis revealed that increasing the UV dose did not significantly decrease the percentage of viable cysts, the fluorescence signal intensity decreased considerably when the cysts were irradiated with a dose equal to or greater than 80 mJ cm−2. Regarding chlorination and boiling treatments, this study demonstrated that no cyst showed fluorescence at the lowest NaClO concentration (0.5 mg/L) and in the shortest boiling time (2 min). Despite some limitations regarding the use of metabolic activity as a viability marker, this methodology is rapid, easy to run and cost-effective. Thus, we conclude that the CFDA-AM staining protocol has the potential to be used to assess Giardia cyst inactivation, although further research is required.
High-throughput Sequencing and Bioinformatics Analysis Reveals the
Neurogenesis Key Targets of Curcumin Action in Mouse Brain with
MCAO
Authors: Li Litao , Cheng Jinming , Ji Yingxiao , Liu Jihong , Zhai Rui , Wang Hebo 
Published: August 2022

Background:
Experimental studies have shown that curcumin exerts neuroprotective
effects in animal models with middle cerebral artery occlusion (MCAO). However, the mechanisms
of protective effects of curcumin in MCAO are not fully understood.

Objective:
This study aims to investigate the key neurogenesis targets of curcumin action in mouse
brain with MCAO.

Methods:
The MCAO models were established in mice. High-throughput sequencing was used to
identify differentially expressed mRNA, lncRNA, and circRNA. The reverse expressed mRNAs,
lncRNA, and circRNA in sham vs. MCAO and MCAO vs. curcumin were identified. Biological
functions were determined by gene ontology (GO) analyses. The protein-protein interaction (PPI)
network of neurogenesis-related genes was constructed. Next, neurogenesis-related lncRNA/
circRNA-miRNA-mRNA ceRNA networks were constructed.

Results:
The total of reverse expressed 1215 mRNAs, 32 lncRNAs, and 43 circRNAs were filtered
based on the 2 series (sham vs. MCAO and MCAO vs. Curcumin). The functional enrichment
analysis of 1215 reverse expressed mRNAs found that they were involved in neurogenesis, neuron
generation, neurogenesis regulation, and others. The PPI network of neurogenesis-related genes
consisted of 115 nodes, including 27 down-regulated genes and 36 up-regulated genes. Furthermore,
the neurogenesis-related lncRNA/circRNA-miRNA-mRNA ceRNAs networks were constructed,
and 5 lncRNA ceRNA networks and 3 circRNA ceRNA networks were explored.

Conclusion:
Our study revealed that curcumin exerts neuroprotective effects by regulating neurogenesis.
The neurogenesis-related lncRNA/circRNA-miRNA-mRNA ceRNA networks are potential
therapeutic targets of curcumin in MCAO. This study provided a theoretical basis for curcumin
exerting neuroprotective effects in MCAO.
MicroRNAs and Long Non-coding RNAs as Novel Targets in Anti-cancer
Drug Development
Authors: Çetinkaya Melisa , Baran Yusuf 
Published: August 2022

Abstract:
Non-coding RNAs comprise the majority of RNAs that have been transcribed from the human genome, and these non-coding RNAs have essential regulatory roles in the cellular processes. They have been discovered to influence the expression of the genes, including tumor-suppressive and oncogenes, that establish the non-coding RNAs as novel targets for anti-cancer drug development. Among non-coding RNAs, microRNAs have been extensively studied in terms of cancer biology, and some microRNA-based therapeutics have been reached in clinical studies. Even though most of the research regarding targeting non-coding RNAs for anti-cancer drug development focused on microRNAs, long non-coding RNAs have also started to gain importance as potential therapeutic targets for cancer therapy. In this chapter, the strategies and importance of targeting microRNAs and long non-coding RNAs will be described, along with the clinical studies that involve microRNA-based cancer therapeutics and preclinical studies that involve long non-coding RNA-based therapeutics. Finally, the delivery strategies that have great importance in the effective delivery of the non-coding RNA-based cancer therapeutics, hence the therapy's effectiveness, will be described.
Antioxidant, α-amylase and α-glucosidase Inhibitory Activities of Aqueous
and Methanolic Extracts From Athamanta sicula L.
Authors: Loucif Karima , Benchikh Fatima , Souici Chawki Ben , Amira Smain 
Published: August 2022

Introduction:
Oxidative stress plays a major role in developing diabetes complications;
therefore, it is possible to use natural antioxidants as therapeutic agents for diabetes.

Aims:
This study aimed to find an important source of phenolics from Athamanta sicula L. (A. sicula)
and confirm that this plant could be a significant source of medically important natural compounds by
confirming its antioxidant, α-amylase and α-glucosidase inhibitory potential.

Methods:
Antioxidant property was performed using 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical
scavenging, metal chelating, and cupric reducing antioxidant capacity methods. The α-amylase and α-
glucosidase inhibitory activities were investigated using an in vitro model. Moreover, polyphenols and
flavonoid contents of the tested extracts were carried out.

Results:
The methanolic extract exhibited the highest phenolic and flavonoid content compared to the
aqueous extract. However, aqueous extract possessed the strongest antioxidant activity (DPPH scavenging,
metal chelating, and Cupric ion reducing antioxidant capacities), α-amylase and α-glucosidase inhibitory
effects. No correlation between phenolic content and antioxidant and enzyme inhibitory activities
of A. sicula L. extracts was observed.

Conclusion:
The results showed that this plant could be a significant source of medically important natural
compounds.
Dolichos biflorus, Useful Food for Patients with Kidney Stones
Authors: Salari Roshanak , Manjiri Mohammad Azad , Asadpour Amir Abbas , Yousefi Mahdi , Ghazanfari Seyed Majid 
Published: August 2022

Abstract:
Urolithiasis is a common problem worldwide manifested with recurrent intermittent pain
episodes, which today is increasing due to changes in lifestyle patterns, including sedentary and
consumption of protein, fat, and fiber-free foods, as well as stress. Today, the role of nutrition in the
formation of kidney stones as well as in its prevention is recognized as a key factor. Dolichos Biflorus is one of the most famous plants that are known as a useful food in the prevention and treatment
of kidney stones. In this review study, electronic databases of PubMed, Scopus, Cochrane, Google
Scholar, and Web of science and Persian medicinal books such as Al- Hawi, Al-Shamel fi-Alsenaat
Altebbiah, Makhzan-al-Advia, and Tohfat al Momenin were searched to identify all the studies reporting the effects of Dolichos Biflorus on kidney stones.
Dolichos Biflorus seeds contain effective substances in preventing kidney stone formation. These
substances include Citrate, Magnesium, Potassium, and Vitamin B6. A protein has been identified in
Dolichos Biflorus grain that has antiseptic and inhibitory stone formation properties. In several studies, the effect of Dolichos Biflorus extract on the dissolution of kidney stones and their prevention
has been investigated.
Dolichos Biflorus seeds can be used as a useful and effective food in patients with kidney stones, in
addition to its nutritional role, as a harmless drug to prevent stone production.
Design and Performance Analysis of a Novel Hybrid PM Five-Phase Fault-
Tolerant Switched-Flux Memory Motor
Authors: Eduku Stephen , Odonkor Ebenezer Narh , Alhassan Mohammed Okoe , Sekyi-Ansah Joseph 
Published: August 2022

Background:
The existing literature depicts that since the advent of the hybrid permanent
magnet switched-flux memory motor (HPMSF-MM), comprehensive research is focused on the design
of three (3)-phase HPMSF-MM topologies, which limits their practical safety crucial design
application range or scope, namely, in electric vehicle (EV).

Objective:
This research work aims to design a novel five (5)-phase fault-tolerant HPMFS-MM using
the synergy of two key PMs, namely, a neodymium magnet (NdFeB) and Alnico magnet, also
known as low coercive force (LCF) with an intrinsic overload fault detection capacity and excellent
flux-regulation capacity to extend it practical application scope.

Methods:
This research paper employs finite element analysis (FEA) via ANSYS Maxwell electromagnetic
software in designing, simulation, and analyzing the proposed fault-tolerant HPMSF-MM.

Results:
The key merit of the Proposed HPMSF-MM is the exhibition of an overload fault protection
mechanism via an injection of a reversed temporary control pulse current into the field winding
(FW) in the event of an overload fault condition to demagnetize the Alnico PM configuration to ensure
that, almost all the generated flux are short-circuited via the design stator-core without linking
the designed rotor as in the case of normal operation is effectively verified via the flux-linkage analysis
in this paper.

Conclusion:
The proposed HPMFS-MM can effectively demonstrate its intrinsic overload fault detection
mechanism, due to its tremendous flux-regulating or weakening capacity, in addition to its
fault-tolerant teeth implementation merit of ensuring physical motor winding phase isolation in an
event of a fault.
Alignment Between Heart Rate Variability From Fitness Trackers and Perceived Stress: Perspectives From a Large-Scale In Situ Longitudinal Study of Information Workers
Authors: Martinez Gonzalo J , Grover Ted , Mattingly Stephen M , Mark Gloria , D’Mello Sidney , Aledavood Talayeh , Akbar Fatema , Robles-Granda Pablo , Striegel Aaron 
Published: August 2022

Background
Stress can have adverse effects on health and well-being. Informed by laboratory findings that heart rate variability (HRV) decreases in response to an induced stress response, recent efforts to monitor perceived stress in the wild have focused on HRV measured using wearable devices. However, it is not clear that the well-established association between perceived stress and HRV replicates in naturalistic settings without explicit stress inductions and research-grade sensors.

Objective
This study aims to quantify the strength of the associations between HRV and perceived daily stress using wearable devices in real-world settings.

Methods
In the main study, 657 participants wore a fitness tracker and completed 14,695 ecological momentary assessments (EMAs) assessing perceived stress, anxiety, positive affect, and negative affect across 8 weeks. In the follow-up study, approximately a year later, 49.8% (327/657) of the same participants wore the same fitness tracker and completed 1373 EMAs assessing perceived stress at the most stressful time of the day over a 1-week period. We used mixed-effects generalized linear models to predict EMA responses from HRV features calculated over varying time windows from 5 minutes to 24 hours.

Results
Across all time windows, the models explained an average of 1% (SD 0.5%; marginal R2) of the variance. Models using HRV features computed from an 8 AM to 6 PM time window (namely work hours) outperformed other time windows using HRV features calculated closer to the survey response time but still explained a small amount (2.2%) of the variance. HRV features that were associated with perceived stress were the low frequency to high frequency ratio, very low frequency power, triangular index, and SD of the averages of normal-to-normal intervals. In addition, we found that although HRV was also predictive of other related measures, namely, anxiety, negative affect, and positive affect, it was a significant predictor of stress after controlling for these other constructs. In the follow-up study, calculating HRV when participants reported their most stressful time of the day was less predictive and provided a worse fit (R2=0.022) than the work hours time window (R2=0.032).

Conclusions
A significant but small relationship between perceived stress and HRV was found. Thus, although HRV is associated with perceived stress in laboratory settings, the strength of that association diminishes in real-life settings. HRV might be more reflective of perceived stress in the presence of specific and isolated stressors and research-grade sensing. Relying on wearable-derived HRV alone might not be sufficient to detect stress in naturalistic settings and should not be considered a proxy for perceived stress but rather a component of a complex phenomenon.
Frackita-v1: un código en Matlab® para el análisis de fracturas geológicas en 1D
Authors: Vásquez-Serrano Alberto 
Published: August 2022

En este trabajo se presenta el código Frackita-v1 escrito en MATLAB®, el cual es una herramienta de análisis unidimensional de fracturas geológicas que automatiza los cálculos de parámetros tales como: dimensión de caja, dimensión de correlación, exponente de Lyapunov, exponente de frecuencia acumulada, coeficiente de variación e intensidad de fracturas. Dichos parámetros son fundamentales para conocer la distribución del tamaño de las fracturas, su cantidad, y arreglo. Esta última variable es importante porque está relacionada con el proceso de flujo de fluidos y con fenómenos como la deformación localizada. Frackita-v1 cubre la necesidad actual de un programa de análisis de fracturas en 1D para la enseñanza (educación), investigación o industria.
El código usa datos del espaciamiento entre fracturas obtenidos mediante el método de líneas de muestreo en cualquier escala, desde una lámina delgada hasta mapas de lineamientos morfológicos. Adicionalmente, Frackita-v1 también genera distribuciones sintéticas de fracturas que ayudan a comprender mejor el uso de los parámetros calculados.
Erratum to “Pleistocene volcanism along the margins of the Canal de Ballenas transform fault, Gulf of California”
Authors: Martín-Barajas Arturo , Schmitt Axel K. , Weber Bodo , López-Martínez Margarita 
Published: August 2022

In the above article, the data of the reference:
Schmitt, A.K., Martín, A., Stockli, D., Farley, K.A., Lovera, O.M., 2013, (U-Th)/He zircon and archaeological
ages for a late prehistoric eruption in the Salton Trough (California, USA): Geology, 2013, 41 (1), 7-10.
Are not correct, they must be:
Schmitt, A.K., Martín, A., Weber, B., Stockli, D.F., Zou, H., Shen, C.C., 2013, Ocean magmatism in sedimentary
basins of the northern Gulf of California rift: Geological Society of America Bulletin, 125(11-12), 1833-1850.

In-text citations to these authors remain unchanged.
This erratum has been attached to the online version of the paper on april 8th, 2022. The editors apologize for this mistake.

Original paper: DOI: http://dx.doi.org/10.22201/cgeo.20072902e.2022.1.1659
DETAILED ENGINEERING DESIGN ARSITEKTUR PADA PERANCANGAN MASJID BER-ARSITEKTUR LAMPUNG
Authors: Sesunan Mas Muhammad Hizbullah 
Published: August 2022

Kegiatan pengabdian ini berfokus pada pembutan gambar detailed engineering design (DED) arsitektural masjid yang menggunakan konsep arsitektur Lampung. Kegiatan diawali dengan survey lokasi masjid dan merangkum kebutuhan pihak pemilik masjid sehingga dapat dilakukan proses pra rancangan. Gambar desain skematis (schematic design) digunakan sebagai bahan diskusi hingga disetujui oleh pemilik, kemudian dikeluarkan gambar dan dokumen desain yang disetujui pemilik yang berisi gambar ilustrasi (3 dimensi) konseptual dan ukuran keterbangunan (conceptual drawing), pada tahap akhir dikbuatkan gambar DED sebagai gambar kerja untuk pekerjaan fisik. Perancangan Masjid dengan pendekatan arsitektur Lampung merupakan salah satu karakter arsitektur islami yang mengembalikan langgam bangunan kepada nilai-nilai keislaman yang bersumber pada Al-quran dan Hadits, yang mengambil beberapa aspek yang dapat dikembangkan pada desain masjid: efisiensi, egaliter, privasi dan kearifan lokal. Kearifan lokal ini sejalan dengan konsep arsitektur lampung pada bangunan masjid yang tanggap lokasi, dan merupakan salah satu cara meningkatkan performa bangunan. Penghawaan alami, arah bukaan bangunan dan pemilihan material, menjadi pertimbangan dalam proses perancangan masjid ini. Luaran bantuan teknis ini dapat dijadikan gambar dokumen pelaksanaan oleh pemilik. Selain itu luaran dapat digunakan untuk rencana pentahapan pembangunan dan ilustrasi pendanaan guna mencari donatur.
Kata kunci: Arsitektur Lampung, Passive Design, Arsitektur Islami, Perancangan Masjid, Pengabdian Kepada Masyarakat.
Memorias sonoras, prisión política y dictaduras en el Cono Sur. Reflexiones trasandinas sensibles
Authors: Cornejo Francisca , Lutowicz Analía , Polti Victoria 
Published: August 2022

El coloquio-conversatorio Memorias sonoras, prisión política y dictaduras en el Cono Sur. Reflexiones trasandinas sensibles se desarrolló el día 11 de septiembre de 2021, día de conmemoración de las víctimas de violencias políticas durante la dictadura militar chilena. Fue organizado por la línea Arte y Política del Núcleo de Sociología del Arte y las Prácticas Culturales de la Facultad de Ciencias Sociales de la Universidad de Chile, y contó con la participación de expositoras chilenas y argentinas: Analía Lutowicz, Victoria Polti, Katia Chornik y Francisca Cornejo. A continuación, presentamos tres de las ponencias propuestas para el conversatorio: “Memorias de canciones de Violeta Parra y la Nueva Canción Chilena en mujeres ex presas políticas en la cárcel del Buen Pastor de Valparaíso durante la dictadura militar chilena” a cargo de Francisca Cornejo, “La memoria sonora de las experiencias concentracionarias en Argentina. Escuchando las miradas que construyen los relatos del Terrorismo de Estado durante la última dictadura cívico-militar”, a cargo de Analía Lutowicz y “La performatividad del sonido y la escucha en contextos concentracionarios” de Victoria Polti.
PEMBELAJARAN BLENDED LEARNING DARING DAN LURING PADA MASA PANDEMI COVID-19 DI SDNEGERI BEKA KECAMATAN MARAWOLA KABUPATEN SIGI
Authors: Sunardy  , Gusnarib  , Darmawansyah  
Published: August 2022

Masuknya wabah covid-19 di Indonesia merubah kebiasaan dalam proses pembelajaran di sekolah maupun di perguruan tinggi, yang biasanya belajar dengan tatap muka kini berubah menjadi pembelajaran blended lerning daring dan luring yang bersifat wajib pada masa darurat covid-19. Berkenaan dengan hal tersebut, maka uraian dalam skipsi ini berangkat dari rumusan masalah: Bagaimana penerapan pembelajaran blended learning daring dan luring dan Apa faktor pendukung dan faktor penghambat penerapan pembelajaran blended learning daring dan luring pada masa pandemi covid-19
Penelitian menggunakan pendekatan kualitatif, jenis penelitian yaitu penelitian lapangan. Tekhnik pengumpulan datanya menggunakan tekhnik observasi, wawancara dan dokumentasi. Sumber datanya yaitu kepala sekolah, wali kelas, guru matapelajaran, dan beberapa peserta didik beserta sumber-sumber pendukung lainnya yang mempunyai relevansi dengan penelitian ini.
Hasil penelitian menunjukan bahwa dalam implementasinya SD Negeri Beka telah berhasil melakukan desain model pembelajaran yang menyesuaikan pada perkembangan zaman, khususnya pada masa pandemi covid-19. Mulai dari perencanaan, pelaksanaan, penilaian dan evaluasi. Hal ini memiliki nilai positif secara otomatis tenaga pendidik dan tenaga kependidikan dilatih dalam berkreatifitas, berinofasi mendesain model pembelajaran, dan meningkatkan pembelajaran berbasis teknologi untuk mencapai tujuan pembelajaran. Berdasarkan penerapanya, juga memiliki faktor pendorong dan penghambat yang sudah diurai dalam penelitian ini.
Implikasi dari penelitian ini yaitu kepala sekolah hendaknya menjadi supervisor yang baik dan memberikan pemahaman tentang kreativitas yang harus dimiliki bagi seluruh pendidik, untuk seluruh pendidik dan tenaga kependidikan diharap mampu membimbing dan memotivasi peserta didik dalam proses pembelajaran daring maupun luring, dan kepada peserta didik diharapkan lebih aktif dan semangat dalam menerima pelajaran.
Real Estate Economic Development Based on Logarithmic Growth Function Model
Authors: Ma Nan 
Published: August 2022

Abstract
This article uses a logarithmic growth model to analyze the correlation between the national economy and real estate. It reveals the Granger causality between the national economy and the real estate economy. The results show a long-term equilibrium relationship and a two-way Granger causality between real estate prices and economic growth. Excessive growth in real estate prices will create bubbles and will also drive economic growth backward.
Financial Crisis Early Warning Model of Listed Companies Based on Fisher Linear Discriminant Analysis
Authors: Li Jie , Alalkawi Talal 
Published: August 2022

Abstract
This article first uses a new method of nonlinear combination forecasting based on neural networks to construct a financial crisis early warning model and conduct an empirical study. The drafting article uses Fisher’s second-class linear discriminant analysis and binary logistic regression to establish a three-year early warning model for listed companies before the financial crisis. Empirical research shows that this early warning model applies to various industries. It can play a certain role in predicting and preventing the financial crisis of Chinese companies.
Optimal Solution of the Fractional Differential Equation to Solve the Bending Performance Test of Corroded Reinforced Concrete Beams under Prestressed Fatigue Load
Authors: Chen Cheng , Mohamed Hamdy 
Published: August 2022

Abstract
With the help of fractional differential equations, this article studies the failure morphology, fatigue strength, and fatigue life of corroded reinforced concrete beams under fatigue loading. Studies have shown that the mid-span deflection of low-corrosion reinforced concrete beams is smaller than that of uncorroded reinforced concrete beams. The corrosion-fatigue coupling effect accelerates the fatigue crack growth rate of steel bars. This reduces the fatigue modulus of concrete and causes the stiffness of the beam to degrade. The research results provide a theoretical basis for the fatigue performance evaluation of corroded reinforced concrete beams.
Part 2: Examining Heteronormativity, Reprocentricity, and Ecology
Authors: Brochu-Ingram Gordon Brent , Hobbs Peter , Sandilands Catriona 
Published: August 2022

This is a portion of a roundtable discussion on queer ecologies held on 11 September 2014. The roundtable is also available as a podcast and was produced in collaboration with CoHearence, an initiative of graduate students in the Faculty of Environmental Studies suppored by NiCHE (Network in Canadian History and Environment).