bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Acute Calcium Intake on Bone Turnover Markers during a Training Day in Elite Male Rowers
Authors: LUNDY BRONWEN , MCKAY ALANNAH K. A. , FENSHAM NIKITA C. , TEE NICOLIN , ANDERSON BRYCE , MORABITO AIMEE , ROSS MEGAN L. R. , SIM MARC , ACKERMAN KATHRYN E. , BURKE LOUISE M. 
Published: August 2022

ABSTRACT

Introduction
Although an acute exercise session typically increases bone turnover markers (BTM), the impact of subsequent sessions and the interaction with preexercise calcium intake remain unclear despite the application to the “real-life” training of many competitive athletes.

Methods
Using a randomized crossover design, elite male rowers (n = 16) completed two trials, a week apart, consisting of two 90-min rowing ergometer sessions (EX1, EX2) separated by 150 min. Before each trial, participants consumed a high (CAL; ~1000 mg) or isocaloric low (CON; <10 mg) calcium meal. Biochemical markers including parathyroid hormone (PTH), serum ionized calcium (iCa) and BTMs (C-terminal telopeptide of type I collagen, osteocalcin) were monitored from baseline to 3 h after EX2.

Results
Although each session caused perturbances of serum iCa, CAL maintained calcium concentrations above those of CON for most time points, 4.5% and 2.4% higher after EX1 and EX2, respectively. The decrease in iCa in CON was associated with an elevation of blood PTH (P < 0.05) and C-terminal telopeptide of type I collagen (P < 0.0001) over this period of repeated training sessions and their recovery, particularly during and after EX2. Preexercise intake of calcium-rich foods lowered BTM over the course of a day with several training sessions.

Conclusions
Preexercise intake of a calcium-rich meal before training sessions undertaken within the same day had a cumulative and prolonged effect on the stabilization of blood iCa during exercise. In turn, this reduced the postexercise PTH response, potentially attenuating the increase in markers of bone resorption. Such practical strategies may be integrated into the athlete’s overall sports nutrition plan, with the potential to safeguard long-term bone health and reduce the risk of bone stress injuries.
Study on the clinical correlation between the expression of serum TNF-α and iNOS as well as cognitive impairment and disease burden in patients with schizophrenia
Authors: Peng Shouning , Liang Changcai , Deng Shimin , Fu Yanbo 
Published: August 2022

Objectives: To investigate the clinical correlation between the expression of serum tumor necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS) as well as cognitive impairment and disease burden in patients with first-episode schizophrenia.
Methods: A total of 102 patients with first-episode schizophrenia admitted to the Department of Psychiatry, Hainan Province Anning Hospital from June 2018 to June 2020 were randomly selected as the observation group, and 102 healthy people who underwent physical examination in our hospital during the same period were selected as the control group. Enzyme-linked immunosorbent assay (ELISA) was used to detect the expression level of serum TNF-α in each group, and the colorimetric method was adopted for detecting the expression level of serum iNOS in each group; Moreover, cognitive function of patients was assessed by MATRICS Consensus Cognitive Battery (MCCB), disease burden was assessed by Family Burden of Disease Scale (FBS), and the correlation between the expression of serum TNF-α and iNOS as well as cognitive impairment and disease burden was analyzed by Pearson method.
Results: The serum levels of TNF-α, iNOS, trail making test scores and FBS scores of the observation group were significantly higher than those of the control group (p<0.05), while the scores of symbolic coding, verbal memory, maze, visual memory, and semantic fluency were significantly lower than those of the control group (p<0.05); Pearson correlation analysis results showed that the serum levels of serum TNF-α and iNOS in the observation group were positively correlated with the trail making test and FBS scores respectively (p<0.05), and negatively correlated with the scores of symbolic coding, verbal memory, maze, visual memory, and semantic fluency (p<0.05).
Conclusions: Patients with first-episode schizophrenia have remarkably increased expression levels of serum TNF-α and iNOS, which is associated with cognitive impairment and disease burden.
doi: https://doi.org/10.12669/pjms.38.7.5326
How to cite this:Peng S, Liang C, Deng S, Fu Y. Study on the clinical correlation between the expression of serum TNF-α and iNOS as well as cognitive impairment and disease burden in patients with schizophrenia. Pak J Med Sci. 2022;38(7):---------. doi: https://doi.org/10.12669/pjms.38.7.5326
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Passenger-Centric Slot Allocation at Schedule-Coordinated Airports
Authors: Birolini Sebastian , Jacquillat Alexandre , Schmedeman Phillip , Ribeiro Nuno 
Published: August 2022

Schedule coordination is the primary form of demand management used at busy airports. At its core, slot allocation involves a highly complex combinatorial problem. In response, optimization models have been developed to minimize the displacement of flight schedules from airline requests, subject to physical and administrative constraints. Existing approaches, however, may not result in the best itineraries for passengers. This paper proposes an original passenger-centric approach to airport slot allocation to maximize available itineraries and minimize connecting times. Because of the uncertainty regarding passenger demand, the proposed approach combines predictive analytics to forecast passenger flows in flight networks from historical data and prescriptive analytics to optimize airport slot assignments in view of flight-centric and passenger-centric considerations. The problem is formulated as a mixed-integer nonconvex optimization model. To solve it, we propose an approximation scheme that alternates between flight-scheduling and passenger-accommodation modules and embed it into a large-scale neighborhood search algorithm. Using real-world data from the Singapore Changi and Lisbon Airports, we show that the proposed model and algorithm return solutions in acceptable computational times. Results suggest that slot-allocation outcomes can be made much more consistent with passenger flows at a relatively small cost in terms of flight displacement. Ultimately, this paper provides a new paradigm that can create more attractive flight schedules by bringing together airport-level considerations, airline-level considerations, and, for the first time, passenger-level considerations. Funding: Financial support from the Civil Aviation Authority of Singapore [Project on Airfield Management and Economics] is gratefully acknowledged. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2022.1165 .
Study on forbidden pitch in plasmonic lithography: taking 365 nm wavelength thin silver film-based superlens imaging lithography as an example
Authors: Ding Huwen , Liu Lihong , Dong Lisong , Han Dandan , Fan Taian , Zhang Libin , Wei Yayi 
Published: August 2022

Plasmonic lithography can make the evanescent wave at the mask be resonantly amplified by exciting surface plasmon polariton (SPP) and participate in imaging, which can break through the diffraction limit in conventional lithography. It provides a reliable technical way for the study of low-cost, large-area and efficient nanolithography technology. However, there is also a phenomenon in plasmonic lithography similar to the forbidden pitch in conventional projection lithography. In this paper, combined with the imaging model and the optical transfer function (OTF), the theoretical analysis points out the reasons for the existence of the phenomenon of forbidden pitch in plasmonic lithography. Taking the 365 nm wavelength Ag thin film-based superlens imaging lithography as an example, the positions of the forbidden pitches of the 1:1 mask, the bright-field mask and the dark-field mask are calculated separately, and the key factors affecting their positions are pointed out. Simulation is carried out through commercial software, and the correctness of theoretical analysis is verified. Finally, we summarize and give some possible suggestions for solving this problem, including exploring better illumination methods, avoiding the patterns with forbidden pitch in the design, or by adding assistant feature to the design.
Antithrombotic therapy for secondary prevention in patients with stroke or transient ischemic attack: A multiple treatment network meta-analysis of randomized controlled trials
Authors: Tornyos Dániel , Komócsi András , Bálint Alexandra , Kupó Péter , El Abdallaoui Oumaima El Alaoui , Szapáry László , Szapáry László Botond 
Published: August 2022

Objective
As stroke represents one of the leading causes of mortality and disability worldwide, we aimed to determine the preventive effect of different antiplatelet therapies after an ischemic stroke or transient ischemic attack.

Methods
Network meta-analysis evaluating antiplatelet regimes after an ischemic stroke or transient ischemic attack. Searches were conducted in MEDLINE, EMBASE, and Cochrane Library databases until Nov. 23, 2021, for randomized controlled trials. Direct comparisons within trials were combined with indirect evidence from other trials by using a frequentist model. An additive network meta-analysis model was used to evaluate the influence of individual components. The primary efficacy endpoint was a recurrent stroke, the main safety outcomes were the risk of major bleeding and mortality at the longest available follow-up.

Results
58 randomized controlled trials (175,730 patients) were analyzed. The analysis involved 20 antithrombotic strategies including different antiplatelet agents, combinations with aspirin, and anticoagulant therapies. Cilostazol proved to be the most efficacious in reducing stroke recurrence and the risk of bleeding (RR = 0.66, 95%CI = 0.55–0.80 and RR = 0.39, 95%CI = 0.08–2.01) compared to aspirin, respectively. Intensification with combinations of aspirin with ticagrelor or clopidogrel resulted in a lower risk of stroke recurrence (RR = 0.79, 95%CI = 0.67–0.93 and RR = 0.79, 95%CI = 0.72–0.87) but carried a higher bleeding risk (RR = 3.01, 95%CI = 1.65–5.49 and RR = 1.78 95%CI = 1.49–2.13).

Conclusion
The prognosis of patients with an ischemic stroke or transient ischemic attack is improved with antiplatelets. Cilostazol showed the best risk-benefit characteristics without trade-off with the risk of major bleeding. Improved stroke recurrence with intensified antiplatelet regimens is counterbalanced with higher bleeding risk, and consequently, mortality remains unaffected. Treatment decisions in stroke survivals should integrate the assessment of bleeding risk for better identification of patients with the highest benefit of treatment intensification.

Systematic review registration
Prospero registration number: CRD42020197143, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=197143.
A Comparative Study of the Efficacy of Intravenous Bolus of Mephentermine and Phenylephrine in Maintaining Arterial Blood Pressure During Spinal Anaesthesia in Caesarean Section
Authors: Ranika Manhas  , Khushboo Jain  , Prerna Attal  , Jyoti Priya  , Neel Pankaj  
Published: August 2022

BACKGROUND
Spinal anaesthesia is the most popular and elegant approach for obstetric patients undergoing caesarean section due to its several advantages. Hypotension resulting from sympathectomy due to subarachnoid block can have detrimental effects on the foetus as well as the mother, so needs to be prevented and treated adequately. Vasopressors for the treatment of hypotension have a well-established role as vasodilatation is the primary cause of the reduction in arterial blood pressure. The primary objective of the study was to compare mephentermine and phenylephrine with respect to their clinical efficacy in maintaining arterial blood pressure during spinal anaesthesia in caesarean section and the secondary objective was to determine any untoward effects of the study drugs on the mother and foetus.
METHODS
This prospective, randomized, comparative, double-blind study was conducted among 90 pregnant women of ASA-I physical status having singleton pregnancies in the age group of 18-30 years undergoing elective as well as emergency caesarean section and were randomly allocated in to two groups. Group M (n=45), received 6 mg of mephenterine as an intravenous bolus (volume made up to 1 ml) and Group P (n=45), received 100 g of phenylephrine as intravenous bolus (volume made up to 1 ml) whenever hypotension occurred after spinal anaesthesia. A comparison of the mean values among the two groups was done using a student t-test. To compare more than two variables, ANOVA test was used. The p-values of less than 0.05 were considered statistically significant.
RESULTS
The systolic blood pressure, diastolic blood pressure and mean arterial pressure remained significantly high (P < 0.05) in the phenylephrine group as compared to the mephentermine group. The phenylephrine group also showed a significant fall (P < 0.05) in heart rate as compared to the mephentermine group.
CONCLUSIONS
Both the drugs were effective in treating the hypotension caused by spinal anaesthesia without any adverse effects on the mother as well as on neonatal outcome but phenylephrine had a quicker onset, better maintenance of blood pressure and can be preferred in patients in whom tachycardia is undesirable.
Long non-coding RNA HOXB-AS1 is a prognostic marker and promotes hepatocellular carcinoma cells’ proliferation and invasion
Authors: Chen Yubin , Wang Na , Cao Liangqi , Zhang Dawei , Peng Heping , Xue Ping 
Published: August 2022

Abstract
Long non-coding RNAs (lncRNAs) are broadly transcribed in the genome of human and play critical roles in the progression of multiple diseases. Long non-coding HOXB cluster antisense RNA 1 (HOXB-AS1) is a tumor exciter in various cancers. This study aimed to investigate the involvement of HOXB-AS1 in hepatocellular carcinoma (HCC). In the following study, HOXB-AS1 was unveiled to be highly expressed in HCC tissues as opposed to normal tissues. Silencing of HOXB-AS1 led to the loss of proliferation, migration, and invasiveness of HCC cells, namely Hep3B and Huh7. Moreover, the data showed that expression levels of HOXB-AS1 contribute significantly to the patient’s survival rates. Otherwise, HOXB-AS1 levels in the serum of patients proved HOXB-AS1 as a biomarker for analysis and treatment of HCC. In summary, this study highlights HOXB-AS1 as key upregulated lncRNA in HCC which being an oncogene can cause proliferation and metastasis of HCC cells. The results also highlighted HOXB-AS1 as a promising biomarker for early diagnosis and prognosis of patients with HCC.
Nasopharyngeal tuberculosis: A case report
Authors: Yang Yang , Fang Yuan , Yang GuoNing 
Published: August 2022

Abstract
Nasopharyngeal tuberculosis is a rare disease. Even in areas where tuberculosis is endemic, its incidence is also extremely low. Here, we will report a rare case of nasopharyngeal tuberculosis. A 29-year-old male patient presented with a 2-month history of sore throat, nasal congestion, dysphagia, and low-grade fever. Thickened mucosa in the posterior wall of the nasopharynx was shown from nasopharyngoscopy, covered with a thick, yellowish, purulent secretion that was not easily removed. Computed tomography of the nasopharynx showed thickening of the mucosa in the right and left bilateral walls and the posterior wall with indistinct margins. Histopathological examination diagnosed nasopharyngeal tuberculosis granuloma. Nasopharyngeal tuberculosis is rare and has atypical symptoms. When a new organism appears in the nasopharynx, it should be differentiated from tuberculosis, autoimmune diseases, and tumors, and a tissue biopsy of the new organism should be performed to make a final diagnosis based on histopathology.
Characterization and evaluation of anti-Salmonella enteritidisactivity of indigenous probiotic lactobacilli in mice
Authors: Mustafa Amina , Nawaz Muhammad , Rabbani Masood , Tayyab Muhammad , Khan Madiha 
Published: August 2022

AbstractLactobacilli (n= 24), isolated from human infants and yogurt, showed variablein vitroactivity againstSalmonella enteritidis(8.0 ± 1.0 to 16.6 ± 0.5 mm) and other gut pathogens (9.0 ± 1.0 to 15.3 ± 0.5 mm), as determined by a well diffusion assay. The isolates were identified asLimosilactobacillus fermentum(FY1, FY3, FY4, IL2, and IL5),Lactobacillus delbrueckii(FY6 and FY7),Lactobacillussp. (IL7), andLactobacillus gasseri(IL12). All isolates showed variablein vitrotolerance to acidic pH for 3 h and visible growth at pH 4 and in the presence of 0.3% ox-bile. The antibiotic susceptibility profile ofLactobacillusisolates indicated resistance against vancomycin, ciprofloxacin, streptomycin, and lincomycin. Isolates had variable auto-aggregation and showed variable capabilities to co-aggregate withS. enteritidis. Based on all tested parameters,L. fermentumIL2,L. fermentumIL5, andL. gasseriIL12 were selected for co-culture experiments, followed byin vivoevaluation in Balb/c mice. All the selected isolates resulted in a 100% reduction inS. enteritidisin broth.Lactobacillusisolates efficiently colonized mouse guts and inhibitedS. enteritidiscolonization. Overall, there was ≥99.06% and ≤4.32 Mean log10reduction inSalmonellacounts in mice feces within 7 days. The study, thus, provided characterized lactobacilli that could be considered as potential ingredients for probiotic formulations intended to preventS. enteritidisinfection in humans.
Proteomic analysis of the liver regulating lipid metabolism in Chaohu ducks using two-dimensional electrophoresis
Authors: Ge Kai , Geng Zhaoyu 
Published: August 2022

Abstract
In this study, we aimed to characterize the liver protein profile of Chaohu ducks using two-dimensional electrophoresis and proteomics. The livers were quickly collected from 120 healthy, 84-day-old Chaohu ducks. The intramuscular fat (IMF) content of the left pectoralis muscle was determined using the Soxhlet extraction method. The total protein of liver tissues from the high and low IMF groups was extracted for proteomics. Functional enrichment analysis of the differentially expressed proteins (DEPs) was conducted using gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG). In total, 43 DEPs were identified. Functional enrichment analysis indicated that these DEPs were significantly related to four lipid metabolic processes: carboxylic acid metabolic process, ATP metabolic process, oxoacid metabolic process, and organic acid metabolic process. Three pathways correlated with lipid metabolism were identified using KEGG analysis: glycolysis/gluconeogenesis, pentose phosphate pathway, fructose, and mannose metabolism. Eight key proteins associated with lipid metabolism were identified: ALDOB, GAPDH, ENO1, RGN, TPI1, HSPA9, PRDX1, and GPX1. Protein–protein interaction analysis revealed that the glycolysis/gluconeogenesis pathway mediated the interaction relationship. Key proteins and metabolic pathways were closely related to lipid metabolism and showed a strong interaction in Chaohu ducks.
Early predictors of abnormal MRI patterns in asphyxiated infants: S100B protein urine levels
Authors: Bersani Iliana , Gasparroni Giorgia , Bashir Moataza , Aboulgar Hanna , Mufeed Hala , Iskander Iman , Kornacka Maria , Gruzfeld Darek , Dotta Andrea , Campi Francesca , Longo Daniela , Savarese Immacolata , Braguglia Annabella , Tina Lucia Gabriella , Nigro Francesco , Serpero Laura , Strozzi Maria Chiara , Maconi Antonio , Ianniello Patrizia , Di Battista Caterina , D’Adamo Ebe , Gavilanes Danilo , Gazzolo Diego 
Published: August 2022

Abstract

Objectives
The early detection and stratification of asphyxiated infants at higher risk for impaired neurodevelopment is challenging. S100B protein is a well-established biomarker of brain damage, but lacks conclusive validation according to the “gold standard” methodology for hypoxic-ischemic encephalopathy (HIE) prognostication, i.e. brain MRI. The aim of the present study was to investigate the predictive role of urinary S100B concentrations, assessed in a cohort of HIE infants receiving therapeutic hypothermia (TH), compared to brain MRI.

Methods
Assessment of urine S100B concentrations was performed by immunoluminometric assay at first void and at 4, 8, 12, 16, 20, 24, 48, 72, 96, 108 and 120-h after birth. Neurologic evaluation, routine laboratory parameters, amplitude-integrated electroencephalography, and cerebral ultrasound were performed according to standard protocols. Brain MRI was performed at 7–10 days of life.

Results
Overall, 74 HIE neonates receiving TH were included in the study. S100B correlated, already at first void, with the MRI patterns with higher concentrations in infants with the most severe MRI lesions.

Conclusions
High S100B urine levels soon after birth constitute trustable predictors of brain injury as confirmed by MRI. Results support the reliability of S100B in clinical daily practice and open the way to its inclusion in the panel of parameters used for the selection of cases suitable for TH treatment.
Efficiency analysis of photovoltaic systems installed in different geographical locations
Authors: Demirkiran Muhammet , Karakaya Abdulhakim 
Published: August 2022

Abstract
Many forms of energy are used in daily life. The most needed of these different forms is electricity. If this energy continues to be met with limited resources, it is clearly seen that sufficient energy needs will not be met in the future. Therefore, in the generation of electrical energy, existing resources must be used extremely efficiently. With the development of technology, electrical energy production is carried out more efficiently with non-renewable energy sources. These technological developments, which come to a certain point, can meet the demanded energy need up to a certain level. For this reason, many studies are carried out on renewable energy sources in order to respond to the needed energy demands. Therefore, in this study, the effect of geographical conditions on panel efficiency in electricity generation with solar panels, which is one of the renewable energy sources, was analyzed. Analyzes were carried out with power plant models installed in four different geographical regions of Turkey using the design and simulation software for photovoltaic systems program for PV systems. The effects of latitude, altitude and temperature on electrical energy production were investigated using the established power plant models.