bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forest fire at the K-Pg boundary on the Pacific margin of Baja California, Mexico: timing and causes
Authors: Catharina Amanda Santa , Kneller Benjamin , Marques Juliana , McArthur Adam , Cevallos-Ferriz Sergio , Theurer Thomas , Kane Ian , Muirhead David 
Published: June 2022

Abstract
We report K-Pg-age deposits in Baja California, Mexico, consisting of terrestrial and shallow marine materials re-sedimented onto the continental slope, including corals, gastropods, bivalves, shocked quartz grains, an andesitic tuff with a SHRIMP U-Pb age (66.12 ± 0.65 Ma) indistinguishable from that of the K-Pg boundary, and charred tree trunks. The overlying mudstones show an iridium anomaly, and fungal and fern spores spikes. We interpret these heterogeneous deposits as a direct result of the Chicxulub impact, and a mega-tsunami in response to seismically-induced landsliding. The tsunami backwash carried the megaflora offshore in high-density flows, remobilizing shallow marine fauna and sediment en route. Charring of the trees at temperatures up to >1000°C took place in the interval between impact and arrival of the tsunami, which on the basis of seismic velocities and historic analogues amounted to only tens of minutes at most. This constrains the timing and causes of fires, and the minimum distance from the impact site over which fires may be ignited.
A lack of a definite correlation between male infertility and single nucleotide polymorphisms in sperm mitochondrial genes MT-CO3, MT-ATP6 and MT-ATP8
Authors: Jaweesh Mayyas saleh , Hammadeh Mohamad Eid , Dahadhah Fatina W. , Smadi Mohammad A. Al , Zoubi Mazhar Salim Al , Alarjah Manal Issam Abu , Amor Houda 
Published: June 2022

Abstract
An inability of a man to conceive in a potentially fertile woman is defined as male infertility. It is reported that 30–40% of males in their reproductive years have abnormalities in sperm production, either qualitatively or quantitatively, or both. However, genetic factors result in up to 15% of male infertility cases. The present study aimed to analyze the possible correlations between infertility and polymorphisms in sperm mitochondrial CO3, ATP6 and ATP8 genes in subfertile men. For 67 subfertile and 44 fertile male samples, Sanger sequencing of selected mitochondrial DNA genes was done. A total of twelve SNPs in the MT-CO3 gene: rs2248727, rs7520428, rs3134801, rs9743, rs28358272, rs2853824, rs2856985, rs2854139, rs41347846, rs28380140, rs3902407, and 28411821, fourteen SNPs in the MT-ATP6: rs2001031, rs2000975, rs2298011, rs7520428, rs9645429, rs112660509, rs6650105, rs6594033, rs6594034, rs6594035, rs3020563, rs28358887, rs2096044, and rs9283154, and ten SNPs in the MT-ATP8: rs9285835, rs9285836, rs9283154, rs8179289, rs121434446, rs1116906, rs2153588, rs1116905, rs1116907, and rs3020563 were detected in the case and control groups at different nucleotide positions. Only the rs7520428 in the MT-CO3 and MT-ATP6 showed a statistically significant difference between subfertile and fertile groups in the genotype’s and allele’s frequency test (P < 0.0001 for both). The results of our study suggest that male infertility is linked with rs7520428 SNP in MT-CO3 and MT-ATP6. The studied polymorphic variations in the MT-ATP8 gene, on the contrary, did not reveal any significant association with male infertility
Design of a Compact Tri-band Mimo Antenna With Reduced Mutual Coupling
Authors: rao srinivasa , Babu K. Jagadeesh , Prasad A. Mallikarjuna 
Published: June 2022

Abstract
The mutual coupling analysis in a tri-band MIMO antenna is the subject of this article. The suggested antenna has three frequencies of resonance: 5.8 GHz, 7.2 GHz, and 8.6 GHz. This mutual coupling study is performed in three ways: (1) without the use of any additional structure; (2) with the use of additional structure (2) Polarization diversity (3) Spatial diversity The mutual coupling is negated in the first technique because the current flow in adjacent arms is in the opposite direction. The second method involves altering the distance between them to do mutual coupling analysis. In the third method, mutual coupling analysis is performed for various antenna orientations. Finally, all three approaches are compared in terms of mutual coupling. The MIMO antenna's performance was further tested in terms of radiation pattern, ECC, gain, and efficiency. It's also worth noting that the simulation results match the measured ones.
Surgical management of traumatic spinal injuries in Sylvanus Olympio Teaching Hospital
Authors: Doléagbénou Agbéko Komlan , Djoubairou Ben Ousmanou , Ahanogbé Mensah Kodjo Hobli , Egu Komi , Békéti Anthony Katanga , Kpélao Essossimna , Abalo Anani 
Published: June 2022

Abstract
Introduction : Traumatic spinal injuries (TSI) is a global disease burden in low - and middle–income countries (LMIC). The burden of TSI is higher in LMICs than in developed countries. Despite improvements in TSI management, resource-constrained settings have not benefitted from this progress to the same extent as more developed countries. Hypothese : Spinal implants availability and early surgery are associated with improved neurologic function.Material and methods: This is a retrospective and descriptive study from November 2017 to October 2020. We included adult patients who presented with traumatic spine injury and who underwent surgery stabilization.Results: A total of 93 patients were studied. The population was young (35.92 ± 9.68 years old), men (91.4%). Road traffic accidents accounted for 85% of patients. At presentation, 59.1% of patients had an incomplete neurologic deficit (ASIA B-D). The cervical spine was the most common segment injured (57%). The median time from admission to the operating room was 21.06 ± 11.8 days. After surgery, 15.3% improved by at least 1 ASIA grade. Bedsores (14%) and superficial wound infection (10.8%) were the most typical complications in our series after surgery. Discussion : According to the AANS/CNS guideline, available literature has defined « early » surgery inconsistently, ranging from < 8 hours to < 72 hours. In our series, the median time from admission to the operating room was 21.06 ± 11.8 days (range 2-62). That finding could be explained by the fact that most low-income people have to pay out of their pocket because the rate of medical insurance coverage is low. In the study, only 17.2% of patients have public insurance, and 2.2% private insurance. We performed three types of surgery: anterior cervical discectomy and fusion, anterior cervical corporectomy with tricortical iliac crest graft and plate, and posterolateral thoracic/lumbar fusion. Implant availability for posterior cervical fusion was the principal driver of that decision in our limited resources.Type of study and level of proff: level 3, retrospective cohort study.
Supporting post-pandemic recovery: Capabilities, opportunities, and motivations of practitioners to deliver oral health promotion and behaviour change conversations to parents of young children in community settings.
Authors: Goldthorpe Joanna , Killbee Lauren , Pretty Iain , Cotterill Sarah , Hart Jo , Peters Sarah 
Published: June 2022

Abstract
The COVID-19 pandemic exacerbated vulnerabilities and inequalities in children’s oral health and treatment activity virtually ceased during periods of lockdown. However, opportunities to support the dental workforce through offering some preventative care in outreach settings may exist. This has the additional benefit of potentially reaching children who do not routinely see a dentist. The aim of this study was therefore to investigate views around upskilling practitioners working in strategic community settings to support families of pre-school aged children to adopt and maintain preventative oral health behaviours. Using the Capability, Opportunity and Motivation model of behaviour (COM-B) to structure our research, we conducted semi-structured interviews with 16 practitioners (dental and non-dental) and analysed the data using deductive framework analysis. The data was a good fit with the COM-B model and further themes were developed within each construct, representing insights from the data. Early years practitioners can reach vulnerable children who are not usually brought to see a dentist. Staff have the capability, opportunity and motivation to support the oral health behaviours of families. Further research is needed to identify training needs, acceptability to parents, and supporting dental practice teams to work in partnership with early years settings. In brief: · Preventative dental activity was greatly diminished during the COVID-19 pandemic however there may be opportunities for professionals based outside general dental practice to have oral health behaviour change conversations with parents· Early years practitioners in particular can potentially reach vulnerable children who are not routinely brought to dental check-ups and have the capability, opportunity and motivation to have oral health behaviour change conversations with parents.· Further research is needed to identify training requirements and how to develop supportive relationships with NHS dental teams
A numerical study of Two-Dimensional Magnetized Bioconvective Unsteady fluid flow in two Stretching Parallel Plates with Internal Heating and Chemical Reaction Effects
Authors: Khan Waris , Rasheed Haroon 
Published: June 2022

Abstract
Driven by scientific development, the bio-convection unsteady nanofluid flow has gained enormous attention in research due to its applications in various disciplines such as biosensors, biological polymer synthesis, pharmaceutics, microbial improved oil recovery, and environment-friendly applications. As such, this study aims to investigate the mixed bio-convective magnetized and electrically conducting 2-dimensional flow in view of two extended wall channels subjected to MHD, thermal radiation, and binary chemical reaction effects. A mathematical framework is developed underflow of a nonofluid based on certain conditions. The implication of Soret and Dufour impacts is considered in the model problem. Such a nonlinear mathematical model is tackled by invoking similarity solutions for mass conservation, momentum, temperature, concentration, and micro-organisms expressions. The dimensionless principles (ODEs) are addressed by the efficacy Nactsheim-Swigert shooting along with the iteration process, explicitly through shooting technique (RK-4). The outlines of distinguished emerging constraints on flow fields are offered through the plotted graphic visuals. The impact of physical quantities of engineering interest is offered numerically via tabulated values.
Associations of morbid obesity with late diagnosis of gestational diabetes, and with related obstetrical and neonatal outcomes
Authors: Shqara Raneen Abu , Or Shany , Francis Yara Nakhleh , Weiner Yifat , Lowenstein Lior , Wolf Maya Frank 
Published: June 2022

Abstract
Objective: To investigate associations of maternal obesity with late GDM diagnosis (>34 weeks) and related obstetrical and neonatal outcomes.Study Design: This was a retrospective cohort study of 238 women who underwent late oral glucose tolerance tests (OGTT) (>34 weeks) for suspected macrosomia or polyhydramnios. Obstetrical and perinatal outcomes were stratified by GDM and morbid obesity (BMI>35 kg/m2) status. Obstetrical complications included pre-eclampsia, induction of labor, cesarean delivery, shoulder dystocia, and third or fourth-degree perineal tear. Neonatal outcomes included Apgar score, arterial cord pH, neonatal hypoglycemia, jaundice, the need for phototherapy, and polycythemia. Results: Late GDM rate was 22.2% and increased the risk for macrosomia, large-for-gestational-age fetus, induction of labor; and neonatal hypoglycemia, jaundice, and need for phototherapy. Conclusion: Adverse pregnancy outcomes are related to morbid obesity in women with late GDM; this population requires special surveillance. Repeat GDM screening beyond 34 weeks should be considered.
Small airway dysfunction in idiopathic pulmonary fibrosis
Authors: Yin Chengsheng , Xie Huikang , He Xian , Zhang Yuan , Zhang Aihong , Li Huiping 
Published: June 2022

Abstract
The pathophysiology of IPF is generally considered to be impaired lung interstitium and alveoli but rare airway involvement. The objective of this study is to investigate the actual occurrence of IPF comorbid small airway dysfunction (SAD) and its impact on survival.Data from inpatients diagnosed with IPF at Shanghai Pulmonary Hospital (Shanghai, China) from 2011 to 2021 were retrospectively collected and analyzed. Lung function parameters were used to assess SAD. A total of 243 patients with IPF were included in this retrospective study, and 84 cases (84/243, 34.57%) were diagnosed with SAD. The lung histopathology showed that all 48 cases undergoing lung transplantation presented diversified degrees of airway lesions, of which 18 patients (18/48, 37.5%) diagnosed with SAD before lung transplantation had a higher proportion of airway distortion and obliteration. The possible risk factors associated with IPF comorbid SAD were smoking, male, younger age, and high CT fibrosis and emphysema scores. By univariate Fine-Grey regression, the hazard rate (HR) of IPF comorbid SAD was 1.725 (95% CI 1.071, 2.777, p<0.05). After adjusting the CTPF model and GAP model, the value of HR was 1.714 (95% CI 1.043, 2.816, p<0.05) and 1.731 (95% CI 1.074, 2.788, p <0.05), respectively. These findings suggested that IPF comorbid SAD was an independent risk factor for the mortality of IPF patients.
A Probabilistic Computational Framework for the Prediction of Corrosion-Induced Cracking in Large Structures
Authors: Qian Guofeng , Tantratian Karnpiwat , Chen Lei , Hu Zhen , Todd Michael D. 
Published: June 2022

Abstract
Corrosion can initiate cracking that leads to structural integrity reduction. Quantitative corrosion assessment is challenging, and the modeling of corrosion-induced crack initiation is essential for model-based corrosion reliability analysis of various structures. This paper proposes a probabilistic computational analysis framework for corrosion-to-crack transitions by integrating a phase-field model with machine learning and uncertainty quantification. An electro-chemo-mechanical phase-field model is developed to predict pitting corrosion evolution, in which stress is properly coupled into the electrode chemical potential. A crack initiation criterion based on morphology is proposed to quantify the pit-to-cracking transition. A spatio-temporal surrogate modeling method is developed to facilitate this, consisting of a Convolution Neural Network (CNN) to map corrosion morphology to latent spaces, and a Gaussian Process regression model with a nonlinear autoregressive exogenous model (NARX) architecture for prediction of corrosion dynamics in the latent space over time. It enables the real-time prediction of corrosion morphology and crack initiation behaviors (whether, when, and where the corrosion damage triggers the crack initiation), and thus makes it possible for probabilistic analysis, with uncertainty quantified. Examples at various stress and corrosion conditions are presented to demonstrate the proposed computational framework.
Looking for a magic island in the sea of agriculture: factors affecting forest patch attractiveness for wild boar in human-dominated landscape
Authors: Ferens Michał , Borkowski Jakub , Załuski Dariusz 
Published: June 2022

Abstract
Context Landscape fragmentation carries the risk of habitat loss for many animal species. This may include wild boars, which are one of the main culprits of conflicts with humans, while isolated patches of forest (forest islands) scattered in the agricultural landscape may affect its ecology and the pressure on the crops. Objectives This study aimed to understand the importance of small forest islands located in a human-dominated agricultural landscape in the ecology of wild boar. It explores what features, both of the interior and exterior of the islands, influence their use. Methods The study area covered approximately 220,000 ha of northern Poland, where wild boar use of 200 islands distributed across the agricultural landscape was investigated. For this purpose, the method of counting pellet groups was applied on transects of a total length of 51.6 km. In order to compare the use of islands with compact forest complexes, 84 km of transects were made in the latter, divided into developmental stages and forest type. Results Among the features of the interior of the islands, cover conditions and the main species of trees had a positive influence on the wild boar use. The utilization also depended on the presence of human settlements, other islands, and the type of agricultural crop around the island. When comparing island use to compact forest complexes, islands were used more often than forest regeneration sites and mature stands, but less often than pre-thickets. For the 25% most frequently used by wild boar, islands were more attractive than virtually all stand development stages in compact forest complexes. Conclusions Due to the cover conditions provided, the occurrence of islands in the agricultural space enables wild boars to use areas more distant from compact forest complexes. This may cause the spread of damage caused by wild boars in the fields, but on the other hand it may reduce the pressure on agricultural areas in the immediate vicinity of compact forest complexes. Intensification of hunting pressure in the vicinity of islands with specific characteristics (e.g. good cover conditions, considerable distance from human settlements) will increase the effectiveness of wild boar population control in the agricultural landscape and will have a limiting effect on the damage caused by this species in the fields.).
Analysis of the drainage effect of different incisions for high complex anal fistula based on FLUENT hydrodynamic simulation
Authors: Zhang Jiamin , Li Xiang , Ma Jiaze , Chen Peng , Ding Kang , Luo Qian 
Published: June 2022

Abstract
Purpose: The biomechanical characteristics of the trauma size and postoperative drainage of different incisions for high complex anal fistula surgery were compared by numerical simulation analysis to provide a theoretical basis for clinical selection of minimally invasive incisions for surgery.Methods: Using FLUENT finite element software, a typical incision finite element model was established to obtain incision areas, and the total mass outlet flow within 200 s was calculated to evaluate the drainage effect of each incision.Results: The incisions with the largest to smallest areas were the curved, spindle, and curved plus extended groove incision, indicating that the curved plus extended groove incision caused the least damage to the perianal skin muscles. Conversely, the incisions with the largest to smallest total outlet flow were as follows: curved plus extended groove, spindle, curved, and straight incision, suggesting that the curved plus extended groove model had the best diversion effect, and the curved incision had better diversion effect than that of the straight incision.Conclusion: The curved plus extended groove surgical incision had the smallest incision area, minimized damage to the perianal skin and muscle tissue, conformed to the concept of minimally invasive surgery, ensured adequate drainage of exudate, maintained the normal growth of granulation tissue on the wound surface, preserved the original form of the anus, and thus better protected the function of the anus. This improved the quality of life of patients requiring high complex anal fistulas.
DNMT1/PKR double knockdowned HepG2 (HepG2-DP) cells have high hepatic function and differentiation ability
Authors: Tanaka-Yachi Rieko , Aizawa Kazuko , Shimizu Kie , Akutsu Hidenori , Nakamura Kazuaki 
Published: June 2022

Abstract
HepG2 cells are widely used as a human hepatocytes model, but their functions, including drug metabolism, are inferior to primary hepatocytes. We previously reported that the hepatic gene expressions in HepG2 cells were upregulated by treatment with zebularine, which is an inhibitor of DNA methylation, through the inhibition of both DNA methyltransferase 1 (DNMT1) and double-stranded RNA-dependent protein kinase (PKR). In this study, we established a new HepG2 cell subline, HepG2-DP cells, by stable double knockdown of DNMT1 and PKR and evaluated its function. Albumin production, expression of CYP1A2 genes, and accumulation of lipid droplets were increased in HepG2-DP cells compared with the original HepG2 cells. Comprehensive gene expression analysis of transcription factors revealed that the expression of important genes for hepatic function, such as HNF4a, FOXA1, FOXA2, FOXA3, and various nuclear receptors, was upregulated in HepG2-DP cells. These results indicate that the newly established HepG2-DP cells are a highly functional hepatocyte cell line. In addition, we investigated whether HepG2-DP cells are able to mature by differentiation induction, since HepG2 cells are derived from hepatoblastoma. The gene expression of major CYPs and Phase II, III drug-metabolizing enzyme genes was significantly increased in HepG2-DP cells cultured in differentiation induction medium. These results suggest that HepG2-DP cells can be further matured by the induction of differentiation and could therefore be applied to studies of drug metabolism and pharmacokinetics.
Human γδ T cells induce CD8+ T cell antitumor responses via antigen-presenting effect through HSP90-MyD88-mediated activation of JNK
Authors: Wang Shengdong , Li Hengyuan , Chen Tao , Zhou Hao , Zhang Wenkan , Yu Xiaohua , Lou Yu , Li Binghao , Yinwang Eloy , Wang Zenan , Xue Yucheng , Qu Hao , Lin Peng , Sun Hangxiang , Teng Wangsiyuan , Mou Haochen , Chai Xupeng , Lin Nong , Cai Zhijian , Ye Zhaoming 
Published: June 2022

Abstract
Background
Human Vγ9Vδ2 T cells have attracted considerable attention as novel alternative antigen-presenting cells (APCs) with the potential to replace dendritic cells in antitumor immunotherapy owing to their high proliferative capacity and low cost. We seek to evaluate the effect of antigen-presenting γδ T cells (γδ T-APCs) in priming tumor-specific immune responses and clarify the mechanism by which γδ T cells develop antigen-presenting features.
Methods
The effect of γδ T-APCs in inducing antitumor responses of CD8+ T cells against osteosarcoma cells were tested both in vitro and in vivo. The mechanism by which γδ T cells develop APC features were further explored.
Results
Human γδ T cells stimulated by zoledronate markedly upregulated APC-related markers and effectively activated CD8+ T cells via cross-presentation of tumor antigen. γδ T-APCs were found to induce robust CD8+ T cell responses against osteosarcoma cells in vitro. In xenograft animal models, γδ T-APCs significantly suppressed osteosarcoma growth by priming CD8+ T cells. Mechanistically, activated γδ T cells produced increased HSP90 and fed back to upregulate MyD88, followed by JNK activation and subsequent improved CCL5 secretion, leading to enhanced CD8+ T cell cross-priming.
Conclusions
This study demonstrates the effect and mechanism of γδ T-APC-mediated cross-presentation in inducing the antitumor responses of CD8+ T cells. Our data suggest Vγ9Vδ2 T cells represent a promising alternative APC for the development of γδ T cell-based tumor immunotherapy.