bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of Administrative Databases and Big Data on Understanding Glioma Treatment—A Systematic Review
Authors: Owens Monica-Rae , Nguyen Sarah , Karsy Michael 
Published: February 2022

Abstract
Background Gliomas are a heterogeneous group of tumors where large multicenter clinical and genetic studies have become increasingly popular in their understanding. We reviewed and analyzed the findings from large databases in gliomas, seeking to understand clinically relevant information.
Methods A systematic review was performed for gliomas studied using large administrative databases up to January 2020 (e.g., National Inpatient Sample [NIS], National Surgical Quality Improvement Program [NSQIP], and Surveillance, Epidemiology, and End Results Program [SEER], National Cancer Database [NCDB], and others).
Results Out of 390 screened studies, 122 were analyzed. Studies included a wide range of gliomas including low- and high-grade gliomas. The SEER database (n = 83) was the most used database followed by NCDB (n = 28). The most common pathologies included glioblastoma multiforme (GBM) (n = 67), with the next category including mixes of grades II to IV glioma (n = 31). Common study themes involved evaluation of descriptive epidemiological trends, prognostic factors, comparison of different pathologies, and evaluation of outcome trends over time. Persistent health care disparities in patient outcomes were frequently seen depending on race, marital status, insurance status, hospital volume, and location, which did not change over time. Most studies showed improvement in survival because of advances in surgical and adjuvant treatments.
Conclusions This study helps summarize the use of clinical administrative databases in gliomas research, informing on socioeconomic issues, surgical outcomes, and adjuvant treatments over time on a national level. Large databases allow for some study questions that would not be possible with single institution data; however, limitations remain in data curation, analysis, and reporting methods.
Dual-Energy Computed Tomography in Diffuse Liver Diseases
Authors: Marri Uday Kumar , Madhusudhan Kumble Seetharama 
Published: February 2022

AbstractDual-energy computed tomography (DECT) is an advancement in the field of CT, where images are acquired at two energies. Materials are identified and quantified based on their attenuation pattern at two different energy beams using various material decomposition algorithms. With its ability to identify and quantify materials such as fat, calcium, iron, and iodine, DECT adds great value to conventional CT and has innumerable applications in body imaging. Continuous technological advances in CT scanner hardware, material decomposition algorithms, and image reconstruction software have led to considerable growth of these applications. Among all organs, the liver is the most widely investigated by DECT, and DECT has shown promising results in most liver applications. In this article, we aim to provide an overview of the role of DECT in the assessment of diffuse liver diseases, mainly the deposition of fat, fibrosis, and iron and review the most relevant literature.
The pattern of breeding and management within the New Zealand Thoroughbred breeding industry 2005–2015. 1. The stallion population
Authors: Chin Y. Y. , Rogers C. W. , Gee E. K. , Stafford K. J. , Cameron E. Z. 
Published: February 2022

Context There has been a contraction within the New Zealand Thoroughbred racing industry and there are limited data demonstrating how this has affected, or been reflected, within the breeding industry that supplies horses for the racing industry. A reduction in the breeding industry, to a greater extent in the sector servicing domestic rather than export market has been speculated. Aim To describe the demographics, breeding pattern, reproductive career and workload of New Zealand Thoroughbred stallions between 2005 and 2015. Methods The breeding records of all Thoroughbred stallions covering >10 mares during 2005/2006–2015/2016 breeding seasons and the lifetime breeding records of all the mares covered by these stallions were extracted from the New Zealand Thoroughbred Racing website. The demographics, population numbers, career pattern, and 10-year trend in market share of stallions in different stud fee categories were examined using descriptive analysis. The stallion’s reproductive workload was modelled deterministically. Results The breeding population reduced over the 10 years examined (mares by 20%, sires by 32%). This industry consolidation was almost entirely due to the 50% reduction in the number of mares mated to the low-priced stallions, which generated horses for the domestic market. The relative proportion of mares sent to medium- and high-priced stallions (breed to sell and export sector) doubled. The commercial breeding career of low- and medium-priced stallions and shuttle stallions was short (4–5 years). The number of mares covered by a stallion increased with stud fee category. Stallions covered a greater number of mares in October and November than in September and December because of the restricted opportunity to cover foaled mares early in the season, caused by the long gestation length of mares and the need to cover mares before December. Conclusions Findings in this study support that the contraction in the New Zealand Thoroughbred breeding industry was due to a reduction in the industry sector that focuses primarily on supplying horses for domestic racing. Commercial pressure and biological constraints heavily influenced the reproductive management of the breeding industry. The breeding management of stallions during the season is heavily influenced by stallion service fee category, which reflects his book size and the commercial appeal of the resultant progeny. Implications The contraction within the domestic sector of the breeding industry was reflected in the concurrent contraction within New Zealands domestic racing population and fewer colts and geldings entering racing. Industry breeding trends demonstrate that economic viability and optimisation of revenue depend on the breeding industry focusing on the export rather than domestic market.
Finding alternative uses for Australian rosella (
Authors: Batley Ryan J. , Johnson Joel B. , Mani Janice S. , Broszczak Daniel A. , Naiker Mani 
Published: February 2022

Context Rosella (Hibiscus sabdariffa L.) is a relatively new crop in Australia, with only a few commercial producers. The calyces are harvested for human consumption, with the seed pods often discarded as a waste byproduct. However, this material may have potential as a livestock feed supplement or as a value-added product in the food processing industry. Aims This study aimed to investigate the nutritional potential of rosella pods for use as a feed supplement, including an in vitro assessment of their digestibility in beef cattle. Methods Samples of rosella plants were separated into leaves, pods and calyces, then freeze-dried and ground. These products were measured in duplicate for their antioxidant capacity, as well as protein, metal, phenolic and anthocyanin content. Samples of the dried rosella pods (n = 3) underwent in vitro digestibility analysis using rumen/pepsin digestions and were compared with samples of commercial feedstock (n = 3). The resulting simulated gastrointestinal fluids from these digestions were tested for antioxidant capacity and phenolic content. Key results The highest antioxidant and phenolic contents of plant parts were observed in the pods (14 300 mg Trolox equivalents and 2960 mg gallic acid equivalents 100 g−1, respectively), highlighting their potential for human or animal nutrition. The pods also contained moderate to high levels of minerals including calcium, potassium, sodium, magnesium, copper, iron, manganese and zinc. Although the in vitro dry matter digestibility was lower (P < 0.001) than that of a conventional grain feedstock, the rosella pod substrate released significantly higher (P = 0.02) levels of antioxidants upon digestion than the commercial feedstock. Conclusion Although rosella pod digestibility was lower than that of a conventional grain feedstock, it was comparable to mean values for Australian hays and silages. Given the higher levels of antioxidants released during digestion, rosella waste product has potential to be used in small amounts as a feed supplement, with the added benefit of enhancing free radical quenching ability. Implications This study provides evidence for further investigation of the use of rosella waste as an animal feed, which would improve sustainability in agriculture as well as potentially improve animal health.
The death of political possibility? Reading State and society in Nigeria 40 years on
Authors: Roelofs Portia 
Published: February 2022

ABSTRACT
In this 2019 reboot of his collection of essays from the 1970s, Gavin Williams traces the lingering the impact of colonialism and international capital on Nigeria’s political economy, the shaky development of an indigenous industrial class and the changing role of the state in national development. However, reading the book, it is not clear what such an analysis is for. Is it intended as a diagnosis? An indictment? Williams leftist commitments are clear, but amid the painstaking analysis one can ask: what is the point of studying politics? In this review article the author unpicks Williams’ at times contradictory answers to this question and argues that the book demonstrates the relevance of mid twentieth-century Nigerian politics to readers today. She poses the question of how we can navigate the possibility and risks of newly volatile twenty-first-century politics, unchained as it is from the liberal orthodoxy of the past 40 years.
Improved sustainability assessment of the G20’s supply chains of materials, fuels, and food
Authors: Cabernard Livia , Pfister Stephan , Hellweg Stefanie 
Published: February 2022

Abstract
Transparency in global value chains of materials, fuels, and food is critical for the implementation of sustainability policies. Such policies should be led by the G20, who represent more than 80% of global material, fuel, and food consumption. Multi-regional input–output analysis plays an important role for consumption-based assessment, including supply chains and their environmental impacts. However, previous accounting schemes were unable to fully assess the impacts of materials, fuels, and food. To close this gap, we provide an improved method to map key aspects of sustainability along value chains of materials, fuels, and food. The results show that the rise in global coal-related greenhouse gas (GHG) emissions between 1995 and 2015 was driven by the G20’s metals and construction materials industry. In 2015, the G20 accounted for 96% of global coal-related GHG emissions, of which almost half was from the extraction and processing of metals and construction materials in China and India. Major drivers include China’s rising infrastructure and exports of metals embodied in machinery, transport, and electronics consumed by other G20 members. In 2015, the vast majority (70%–95%) of the GHG emissions of metals consumed by the EU, USA, Canada, Australia, and other G20 members were emitted abroad, mostly in China. In contrast, hotspots in the impact displacement of water stress, land-use related biodiversity loss, and low-paid workforce involve the G20’s food imports from non-G20 members. Particularly high-income members have contributed to the G20’s rising environmental footprints by their increasing demand for materials, food, and fuels extracted and processed in lower-income regions with less strict environmental policies, higher water stress, and more biodiversity loss. Our results underline the G20’s importance of switching to renewable energy, substituting high-impact materials, improving supply chains, and using site-specific competitive advantages to reduce impacts on water and ecosystems.
General truncated linear statistics for the top eigenvalues of random matrices
Authors: Grabsch Aurélien 
Published: February 2022

Abstract
Invariant ensembles, which are characterised by the joint distribution of eigenvalues P(λ
1, …, λ

N
), play a central role in random matrix theory. We consider the truncated linear statistics

L

K

=

∑

n
=
1

K

f

(

λ

n

)

with 1 ⩽ K ⩽ N, λ
1 > λ
2 > ⋯ > λ

N
and f a given function. This quantity has been studied recently in the case where the function f is monotonous. Here, we consider the general case, where this function can be non-monotonous. Motivated by the physics of cold atoms, we study the example f(λ) = λ
2 in the Gaussian ensembles of random matrix theory. Using the Coulomb gas method, we obtain the distribution of the truncated linear statistics, in the limit N → ∞ and K → ∞, with κ = K/N fixed. We show that the distribution presents two essential singularities, which arise from two infinite order phase transitions for the underlying Coulomb gas. We further argue that this mechanism is universal, as it depends neither on the choice of the ensemble, nor on the function f.
On the green aurora emission of Ar atmospheric pressure plasma
Authors: LIU Fengwu , NIE Lanlan , LU Xinpei 
Published: February 2022

Abstract
The Ar atmospheric pressure plasma was found to be an excellent laboratorial source for green aurora emission. However, the characteristic and production mechanism of the green aurora emission of the Ar atmospheric pressure plasma are still not clear. In this work, an Ar plasma in a long glass tube which emits intense green aurora light is investigated. With the long glass tube, it can be concluded that the green aurora emission in the Ar plasma is not owing to the mixture of Ar plasma plume with the surrounding air. It is also found that the green aurora emission often appeared beyond the active electrode when the active electrode is placed at the downstream of the gas flow. The green emission disappears when the traces amount of O2 or N2 (about 0.05%–0.07%) is added to Ar. This is because the O2 molecules deactivate the upper state O(1S), which results in the decrease of the green emission. On the other hand, when N2 is added, Ar metastable atoms are quenched by N2, which results in the decrease of O atoms and eventually leads to the decrease of the green emission intensity. The intensity of the green aurora emission increases when the driving voltage frequency increases from 1 to 10 kHz. More importantly, it is found that the green aurora emission is not affected when a grounded stainless steel needle is in contact with the plasma plume. Thus, the green emission is not driven electrically. All these findings are helpful for the understanding of the physics and its applications of atmospheric pressure plasma jet in space physics, laser physics and other application areas.
Kidney health for all: bridging the gap in kidney health education and literacy
Authors: Langham Robyn G , Kalantar-Zadeh Kamyar , Bonner Ann , Balducci Alessandro , Hsiao Li-Li , Kumaraswami Latha A , Laffin Paul , Liakopoulos Vassilios , Saadi Gamal , Tantisattamo Ekamol , Ulasi Ifeoma , Lui Siu-Fai ,   The World Kidney Day Joint Steering Committee, Langham Robyn G , Kalantar-Zadeh Kamyar , Balducci Alessandro , Hsiao Li-Li , Kumaraswami Latha A , Laffin Paul , Liakopoulos Vassilios , Saadi Gamal , Ulasi Ifeoma , Lui Siu-Fai 
Published: February 2022

Abstract
The high burden of kidney disease, global disparities in kidney care and poor outcomes of kidney failure bring a concomitant growing burden to persons affected, their families and caregivers and the community at large. Health literacy is the degree to which persons and organizations have or equitably enable individuals to have the ability to find, understand and use information and services to make informed health-related decisions and actions for themselves and others. Rather than viewing health literacy as a patient deficit, improving health literacy largely rests with healthcare providers communicating and educating effectively in codesigned partnership with those with kidney disease. For kidney policymakers, health literacy provides the imperative to shift organizations to a culture that places the person at the center of healthcare. The growing capability of and access to technology provides new opportunities to enhance education and awareness of kidney disease for all stakeholders. Advances in telecommunication, including social media platforms, can be leveraged to enhance persons’ and providers’ education. The World Kidney Day declares 2022 as the year of ‘Kidney Health for All’ to promote global teamwork in advancing strategies in bridging the gap in kidney health education and literacy. Kidney organizations should work toward shifting the patient-deficit health literacy narrative to that of being the responsibility of healthcare providers and health policymakers. By engaging in and supporting kidney health–centered policymaking, community health planning and health literacy approaches for all, the kidney communities strive to prevent kidney diseases and enable living well with kidney disease.
Global burden of heart failure: a comprehensive and updated review of epidemiology
Authors: Savarese Gianluigi , Becher Peter Moritz , Lund Lars H , Seferovic Petar , Rosano Giuseppe M C , Coats Andrew J S 
Published: February 2022

Abstract
Heart Failure (HF) is a multi-faceted and life-threatening syndrome characterized by significant morbidity and mortality, poor functional capacity and quality of life, and high costs. HF affects more than 64 million people worldwide. Therefore, attempts to decrease its social and economic burden have become a major global public health priority. While the incidence of HF has stabilized and seems to be declining in industrialized countries, the prevalence is increasing due to the ageing of the population, improved treatment of and survival with ischaemic heart disease, and the availability of effective evidence-based therapies prolonging life in patients with HF. There are geographical variations in HF epidemiology. There is substantial lack of data from developing countries, where HF exhibits different features compared with that observed in the Western world. In this review, we provide a contemporary overview on the global burden of HF, providing updated estimates on prevalence, incidence, outcomes, and costs worldwide.
Additive prognostic and diagnostic value of diastolic exercise parameters in patients referred for exercise echocardiography
Authors: Peteiro Jesús , Bouzas-Mosquera Alberto , Barbeito-Caamaño Cayetana , Martin-Alvarez Esteban , Souto-Cainzos Borja , Vazquez-Rodriguez Jose M 
Published: February 2022

Abstract

Aims
Exercise echocardiography (ExE) may evaluate left ventricular (LV) systolic and diastolic function. We aimed to assess the value of diastolic parameters at exercise [early LV inflow velocity to early tissue Doppler annulus velocity (E/e′)] in patients with normal or abnormal resting diastolic function (DF) referred for a clinically indicated ExE.

Methods and results
LV systolic and DF according to ASE/EACVI guidelines and mitral regurgitation (MR) were evaluated at rest in 772 patients (age 67 ± 12 years) with preserved LV ejection fraction (LVEF ≥ 50%). We assessed regional/global LV systolic function at peak exercise, while MR and E/e′ where evaluated in the immediate post-exercise period. Abnormal ExE was defined as ischaemia or fixed wall motion abnormalities, and raised E/e′ values as &gt;15 at rest and at exercise (e′ at the septal level). Patients were grouped as complaining or not of dyspnoea. Events were overall mortality, myocardial infarction, admission for unstable angina or cardiac failure, and coronary revascularization. DF was abnormal at rest in 221 patients (29%) and indeterminate in 77 (10%), with similar percentages in patients with and without dyspnoea. Exercise E/e′ &gt;15 was found in 37% of patients with abnormal DF, 21% with indeterminate DF, and 6% with normal DF (P &lt; 0.001). Patients with abnormal ExE had more often abnormal resting DF (39% vs. 25%, P = 0.001) and exercise E/e′ &gt;15 (25% vs. 13%, P &lt; 0.001) than those with normal ExE. During a median follow-up of 1.68 years, there were 132 events. Independent predictors included peak exercise LVEF [hazard ratio (HR) = 0.93, 95% confidence interval (CI) = 0.91–0.94, P &lt; 0.001], and exercise E/e′ (HR= 1.04, 95% CI = 1.01–1.07, P = 0.01). Neither resting E/e′ values nor resting abnormal DF by ASE/EACVI guidelines, were independent predictors. Annualized event-rates were 43.2% in patients with (+) ExE plus (+) exercise E/e′, 23.8% in those with (+) ExE and (−) exercise E/e′, 7.9% in (−) ExE and (+) exercise E/e′, and 3.6% with both variables normal.

Conclusions
The results of diastolic dysfunction at rest and at exercise were similar between patients with or without dyspnoea referred for ExE, but they were associated with abnormal ExE. Exercise E/e′ reclassified 21% of patients with indeterminate DF and further predicted outcome on top of ExE results.
Wearable cardioverter defibrillator multicentre experience in a large cardiac surgery cohort at transient risk of sudden cardiac death
Authors: Kuehn Christian , Ruemke Stefan , Rellecke Philipp , Lichtenberg Artur , Joskowiak Dominik , Hagl Christian , Hassan Mohamed , Leyh Rainer G , Erler Stefan , Garbade Jens , Eifert Sandra , Grieshaber Philippe , Boening Andreas , Doenst Torsten , Velichkov Ilia , Madej Tomas , Knaut Michael , Hain Andreas , Burger Heiko 
Published: February 2022

AbstractOBJECTIVESThe wearable cardioverter defibrillator (WCD) is an established, safe, effective solution, protecting patients at risk of sudden cardiac death. We specifically investigated WCD use in cardiac surgery patients since data for this patient group are rare.METHODSRetrospective data analysis in 10 German cardiac surgery centres was performed. Cardiac surgery patients with left ventricular ejection fraction (LVEF) ≤35% or after implantable cardioverter defibrillator (ICD) explantation who received WCD between 2010 and 2020 were assessed using LifeVest Network data.RESULTSA total of 1168 patients with a median age of 66 years [interquartile range (IQR) 57–73] were enrolled; 87% were male. Clinical indications included coronary artery bypass grafting (43%), valve surgery (16%), combined coronary artery bypass graft/valve surgery (15%), ICD explantation (24%) and miscellaneous (2%). The median wear time of WCD was 23.4 h/day (IQR 21.7–23.8). A total of 106 patients (9.1%) exhibited ventricular tachycardia. A total of 93.2% of episodes occurred within the first 3 months. Eighteen patients (1.5%) received 26 adequate shocks. The inadequate shock rate was low (8 patients, 0.7%). LVEF improved from a median of 28% (IQR 22–32%) before WCD prescription to 35% (IQR 28–42%) during follow-up. Excluding ICD explant patients, 37% of patients received an ICD.CONCLUSIONSThe risk of sudden cardiac death is substantial within the first 3 months after cardiac surgery. Patients were protected effectively by WCD. Due to significant LVEF improvement, the majority did not require ICD implantation after WCD use. Compliance was high despite sternotomy. This multicentre experience confirms existing data regarding effectiveness, safety and compliance. Therefore, WCD should be considered in cardiac surgery patients with severely reduced LVEF.