bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain Catastrophizing and Substance Misuse: A Scoping Review of the Literature
Authors: Bichon Juliette A. , Bailey Allen J. , Ford Stephanie Friree , Lesser Victoria S. , McHugh R. Kathryn 
Published: January 2025

Abstract

Background
Pain catastrophizing, or the interpretation of pain as unbearable or intolerable, can increase pain-related anxiety and severity. High levels of pain catastrophizing have also been linked to substance use, particularly for substances with analgesic properties. Importantly, behavioral treatments can reduce pain catastrophizing, making them promising interventions for mitigating pain-related substance use. The aim of this scoping review is to summarize literature investigating the relationship between pain catastrophizing and substance use in adults.

Methods
We performed a scoping review of peer-reviewed literature. Included articles had both a measurement of pain catastrophizing and substance use, and reported analyses characterizing the relationship between the two.

Results
Of the 341 abstracts identified, 47 articles met eligibility criteria. Most studies focused on people with chronic pain. Some studies also considered samples with substance use disorders (with and without chronic pain) or acute pain, and general population samples. There was generally a positive association between pain catastrophizing and substance misuse; this association was consistent across multiple samples and substances. Most studies were cross-sectional, although associations were also detected in longitudinal studies. The magnitude of associations tended to be stronger for higher severity substance use and more proximal tests of association. More longitudinal and experimental studies are needed, however, to better delineate these effects.

Discussion
Findings indicate a consistent positive association between pain catastrophizing and substance use, highlighting the potential for interventions targeting pain catastrophizing to reduce negative substance-related consequences.
Evaluation of Retinal Capillary Density using OCT Angiography according to Acute Ischemic Stroke Etiologies - A Matched Case –Control Study
Authors: Debourdeau Eloi , Chamard Chloe , Ayrignac Xavier , Varnier Quentin , Crowdy Hannah , Villain Max , Arquizan Caroline , Daien Vincent , Schiphorst Adrien Ter 
Published: January 2025

Purpose:
To investigate retinal microvascular changes in ischemic stroke patients using optical coherence tomography angiography (OCT-A) and assess these alterations based on stroke etiology.

Methods:
Case–control study conducted at Montpellier University Hospital from May 2021 to March 2022 (IRB: 202000607). Retinal vascular features were compared between strokes patients and age- and sex- matched controls. OCT-A was performed using RTVue-XR-Avanti with AngioVue (Optovue). Multivariate mixed-effects ANCOVA models adjusted for age, sex, intraocular pressure (IOP), and cardiovascular risk factors were used.

Results:
92 eyes were included: 21 with micro/macro-angiopathy stroke, 12 with etiologically ambiguous stroke, 13 with cardioembolic stroke and 46 eyes from control subjects. After adjusting for age, sex, and IOP, stroke patients had significantly lower parafoveal SCP-VD (p = 0.013) and SCP Flow Index (p = 0.023) compared to controls, especially in the macro/micro-angiopathy subgroup. When cardiovascular risk factors were included, only the SCP Flow Index difference remained significant (p = 0.023). OCT-A’s diagnostic accuracy was validated with an AUROC of 0.83.

Conclusion:
OCT-A effectively detects retinal microvascular alterations in stroke patients, with persistent alterations in macro/micro-angiopathy strokes after adjusting for cardiovascular risk factors. These findings support OCT-A’s role in stroke subtype classification.
Laudable Pus, Cocaine, and the Evolution of Wound Management
Authors: Custer Philip L. 
Published: January 2025

Purpose:
To review the long history of wound management, including the methods of skin closure, asepsis, and anesthesia. Periocular techniques will be emphasized.

Methods:
Literature searches and cross-referencing were used to identify historic reports addressing the management of wounds. Foreign language manuscripts were translated using online resources.

Results:
The first written description of suturing dates to around 3000 BC and involved the repair of an eyebrow wound. A wide variety of materials have since been used as ligatures or stitches, including animal intestines, tendons, hair, silk, linen, plant fibers, and metal wire. For much of recorded history, sutures were a primary cause of wound infection and morbidity. There was a time when the resultant drainage was viewed as being beneficial (laudable pus). Many of the discoveries that ultimately led to the practice of asepsis were coincidental. Prior to the development of infiltrative anesthesia in 1894, patients had to endure the discomfort of surgery, occasionally with the sedative effects of wine or cannabis.

Conclusions:
The history of wound closure is a fascinating tale. While there has been a constant evolution, silk and catgut sutures, ligatures, surgical knots, and layered closure have been used for several millennium. Advances in asepsis, in addition to the development of anesthesia, antibiotics, and synthetic sutures, ushered in the modern age of surgery. A knowledge of the past will give us, as oculofacial surgeons, a greater understanding and appreciation of the techniques we use today.
Trends in Demographic, Clinical, Socioeconomic, and Facility-Specific Factors Linked to Eyelid Melanoma Survival: A National Cancer Database Analysis
Authors: Robbins James O. , Huck Nolan A. , Khosravi Pooya , Torabi Sina J. , Woodward Julie A. , Kuan Edward C. , Dermarkarian Christopher R. 
Published: January 2025

Purpose:
This study aimed to analyze demographic, clinical, socioeconomic, and facility-specific factors affecting the survival outcomes of patients diagnosed with eyelid melanoma (EM) between 2004 and 2017 using data from the National Cancer Database.

Methods:
Cases of EM diagnosed between 2004 and 2017 were identified using the National Cancer Database. Patient demographic data, tumor stage (American Joint Committee on Cancer TNM classification), treatment modalities, and socioeconomic variables were collected. Facility-specific variables included patient volume and academic status. Kaplan-Meier survival analyses and multivariate Cox regression models were used to assess 10-year survival and identify significant predictors of mortality.

Results:
A total of 3,235 patients with EM were eligible for demographic analysis. The majority of patients were over 60 years of age and predominantly male. Kaplan-Meier analysis showed a significant decrease in 10-year overall survival with increasing age at diagnosis (p < 0.001), T clinical stage (p < 0.001), and male sex (p = 0.001). Additionally, patients with higher income (p = 0.01), private insurance (p < 0.001), and those treated at high-volume (p = 0.006) and academic facilities (p = 0.005) had improved 10-year overall survival. Multivariate Cox regression identifying independent predictors of EM mortality corroborated these findings.

Conclusions:
Eyelid melanoma survival outcomes were significantly influenced by age, tumor stage, socioeconomic status, and facility characteristics. Treatment at high-volume centers confers a survival advantage, emphasizing the importance of specialized care. These findings underscore the need for early detection and equitable access to improve EM outcomes.
Progress of Baggy Eyelid: An Anatomical Study
Authors: Kakizaki Hirohiko , Ambat Jose Miguel , Naito Munekazu , Takahashi Yasuhiro 
Published: January 2025

Purpose:
To examine microscopically the progress of baggy eyelid formation in the lower eyelid.

Methods:
Histological evaluation of 17 central lower eyelids (11 right and 6 left) from 13 Japanese cadavers (age range: 36–97 years, average: 73.0 years) was performed. The specimens were fixed in 10% formalin and stained with Masson’s Trichrome. The following characteristics were examined: 1) presence of baggy eyelid, 2) thickness of the orbital septum, 3) presence of anterior protrusion of fat and/or orbicularis oculi muscle (OOM), 4) thickness of OOM and subcutaneous tissue at the widest anterior protrusion, and 5) skin thickness.

Results:
The findings were divided into 4 stages: stage 0 (2 eyelids in 1 specimen) absent baggy eyelid, all tissues normal, stage 1 (1 eyelid in 1 specimen) absent baggy eyelid, intermediate orbital septum, anterior dome-like protrusion of fat but minimal OOM projection, thick OOM, subcutaneous tissue, and skin, stage 2 (9 eyelids in 7 specimens) absent or minimal baggy eyelid, intermediate orbital septum, anterior dome like protrusion of fat and OOM, intermediate OOM, with thick subcutaneous tissue and skin, stage 3 (5 eyelids in 4 specimens) with present baggy eyelid, thin orbital septum, severe anterior dome like protrusion of fat and OOM, with thin OOM, subcutaneous tissue and thick skin in mild type, with thin skin in severe type.

Conclusions:
Baggy eyelid appears to be triggered by the anterior protrusion of fat, followed by thinning of the orbital septum, OOM, and subcutaneous tissue in order. Thinner skin may promote severe entity.
Association between diabetes and characteristics of hospitalization in patients with acute pancreatitis
Authors: Kirzhner Alena , Green Hefziba , Lin Guy , Khadija Haitham abu , Cohen Ramon , Mari Andaleeb , Schiller Tal 
Published: January 2025

Objective:
Data on the influence of diabetes and the prognosis of acute pancreatitis (AP) remains limited. We aimed to characterize the clinical course and prognosis of patients hospitalized with a principal diagnosis of AP with and without diabetes.

Methods:
This was a single-center hospital-based observational retrospective cohort study of adult patients admitted to the Department of General Surgery at Kaplan Medical Center with AP between 2017 and 2022. Elaborated data were retrieved from the electronic medical records. The main adverse outcomes included infections, necrotizing pancreatitis, surgery due to these complications, organ failure, intensive care unit admission, in-hospital mortality, length of hospitalization, and three months of all-cause readmission after the index hospitalization.

Results:
350 adult patients with AP were included, of which 101 (29%) had diabetes. Diabetic patients were older and had a higher prevalence of comorbidities. Despite these differences, the presence of diabetes did not correlate with any of the adverse hospitalization outcomes except a three-fold higher risk for re-admissions in the three months post-discharge due to AP complications (9% vs 3%, p=0.025). Using logistic regression, the risk factors significantly associated with unfavorable outcomes among diabetic patients included age, background congestive heart failure (OR 5.064, 95% CI 1.036–24.742, p = 0.045), and hyperglycemia during hospitalization (OR 4.382, 95% CI 1.108–17.325, p = 0.035). Patients who used DPP4 inhibitors at admission were 19 times more likely to have an adverse outcome (OR 18.637, 95% CI 2.510–138.374, p = 0.004), while Metformin and unknown etiology of AP had a protective effect.

Conclusion:
Although diabetic patients had less favorable characteristics at baseline most hospitalization outcomes were comparable to patients without diabetes.
Nevus of Hori in African patients: an entity that is most likely underdiagnosed in clinical practice
Authors: Maruma Frans , Dlova Ncoza , Mofokeng Thabiso Rafaki Petrus , Moloabi Boitshoko Claudia 
Published: January 2025

Background:
Nevus of Hori (HN) has been primarily reported in patients of Eastern Asian descent, with a paucity of data regarding HN occurring in African patients. In this study, we report on South African patients with HN initially thought to have melasma.

Objective:
To characterize the histopathological and clinical phenotypes of HN in African patients.

Methods:
Retrospective data were collected from patients who met the inclusion criteria. These data entailed the clinical distribution, demographic data, Fitzpatrick skin phototype, and histopathologic features of African patients diagnosed with HN from a single private aesthetic center in Bloemfontein, South Africa.

Results:
Thirty patients with an average age of 49 ± 7.37 were included in this analysis. The majority of patients were female (n = 29; 96.67%), and most patients were of Fitzpatrick skin phototype V (n = 22; 73.3%). The most common clinical distribution pattern was bitemporal (76.7%), followed by the zygomatic pattern (20%), mixed type (16.7%), and finally the central forehead pattern (3.3%). Histopathologically, the dendritic cell type of melanocytes was observed in the majority of patients (n = 25; 83.3%), while spindle-shaped cells were observed in few patients (n = 7; 23.33%), and none of the patients had bipolar-type melanocytes.

Limitations:
This study has limitations inherent to small sample size and its inability to accurately generalize the findings.

Conclusion:
HN can clinically mimic melasma in African patients. The most common clinical presentation was bitemporal. To our knowledge, this study is the largest regarding the clinicopathological profile of HN in African patients and it is likely to be the first to report these compelling findings.
Comparison of Clinical and Pathologic Features of Antimitochondrial Antibodies-negative Primary Biliary Cirrhosis and Cholestatic Type Drug-induced Liver Injury
Authors: Xiaohan Ma , Lixia Yang , Xiangyu Zeng , Wanting Liu 
Published: January 2025

Aim:
To compare the respective clinical and pathologic features of antimitochondrial antibodies-negative (AMA-negative) primary biliary cirrhosis (PBC) and cholestatic type drug-induced liver injury (DILI) for clinical differential diagnosis.

Patients and Methods:
Clinical data from 23 patients with AMA-negative PBC and 39 patients with cholestatic type DILI, treated at our hospital between January 2013 and January 2024, were collected and retrospectively analyzed.

Results:
The cholestatic type DILI group exhibited a higher incidence of malaise and abdominal pain compared with the AMA-negative PBC group. Alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, low-density lipoprotein cholesterol, globulin, immunoglobulin G, immunoglobulin M, and anti-gp210/anti-Sp100 antibodies were higher in the AMA-negative PBC group compared with the cholestatic type DILI group. There were differences in the stages of inflammation and fibrosis between the cholestatic type DILI group and the AMA-negative PBC group. Lymphocyte and plasma cell infiltration in the confluent areas was more pronounced in the AMA-negative PBC group, while monocyte infiltration was greater in the cholestatic type DILI group. In the small bile duct reaction, the positive rate was higher in the AMA-negative PBC group compared with the cholestatic DILI group. Conversely, the positive rate of D-PAS staining was greater in the cholestatic type DILI group than in the AMA-negative PBC group. All of these differences were statistically significant (P < 0.05).

Conclusions:
Comparing the AMA-negative PBC with the cholestatic type DILI revealed differences in liver function, lipid profiles, immunoglobulins, autoantibodies, and hepatic histopathologic features. These distinctions facilitate the clinical differentiation between the 2 conditions.
West Nile Neuroinvasive Disease: Case Series and Review of the Literature
Authors: Alter Rachel , Juretschko Stefan , Smith Miriam A. 
Published: January 2025

Background:
West Nile virus (WNV), although underdiagnosed, is the most common mosquito-borne disease and the second most common cause of viral encephalitis in the United States. Fewer than 1% of those infected develop neuroinvasive disease.

Methods:
We present a cluster of 3 cases of neuroinvasive WNV that occurred between August and September 2023 and a review of the literature for neurologic involvement with this virus.

Data Sources:
Sunrise Electronic Health Record; PubMed; Google; Division of Infectious Disease Diagnostics, Northwell Health Laboratories, Little Neck, NY.

Results:
The patients in all 3 cases were admitted with acute encephalopathy and other neurologic impairment. All 3 patients had a serum serologic diagnosis consistent with WNV. However, only one of 3 of the patients underwent a lumbar puncture with cerebrospinal fluid confirmation of WNV.

Areas of Uncertainty:
Clinical and laboratory guidelines have been described for the diagnosis of neuroinvasive WNV infection. This is especially important in patients who do not have cerebrospinal fluid confirmation.

Conclusions:
WNV is underdiagnosed. Furthermore, although neuroinvasive WNV infection is uncommon, this diagnosis should be considered in patients presenting with abnormal neurologic signs and symptoms during the summer months in geographic areas where potential transmission is of concern.
Characteristics of Peripheral Intravenous Catheter Cannulation in Older Japanese Inpatients
Authors: Kitada Motoko , Yamamura Shigeo , Ninomiya Ayako , Kabashima Minoru , Tateno Kazuko , Hori Etsuro 
Published: January 2025

Age-related physiological changes affect various aspects of peripheral intravenous catheter (PIVC) cannulation. However, the characteristics of PIVCs, especially in older patients, have been poorly investigated. In the current cross-sectional observational study, PIVC sizes, PIVC sites, the number of attempts until successful insertion, and the degree of venodilation upon insertion among hospital inpatients aged ≥65 years were investigated, along with measurements of the vessel diameter and depth using ultrasound. In total, 91 PIVC insertions were analyzed. The vessel diameter was estimated to be smaller than that in domestic adult inpatients. Most of the catheters were placed at the ideal site on the first attempt. However, considering the optimal vein-to-catheter ratio, most of the cannulations were oversized and would be oversized even when using a 24-gauge catheter. In addition, obvious differences were found in the vessel diameter, catheter size, and catheter site compared with previous studies conducted outside of Asia. The current study indicates the need for further research on the identification of appropriate veins, and the definition of “appropriate” approaches might vary among countries.
A Conservative Crease-Height-Adjustable Asian Double Eyelid Surgery Technique Based on Live Anatomical Studies
Authors: Yu Arthur Y. , Yu Abigail A. , Boonipat Thanapoon , Pu Lee L.Q. 
Published: January 2025

Background:
Ideal methods for double eyelid crease creation in Asian upper eyelids remain controversial due to the complexity of Asian upper eyelid anatomies. Key confusions include the underestimation of tarsal height and the septum/aponeurosis fusion point height (FPH), which may underlie the unnaturally high creases in many classic double eyelid procedures.

Methods:
A total of 1272 patients had tarsal heights measured. Among 386 patients with orbital septa opened, FPHs and other anatomic findings were also documented. Based on the anatomical findings, a novel method for double eyelid crease formation was designed. This method involves preserving the pretarsal fibrofatty tissue and using horizontal mattress sutures to connect the orbicularis oculi muscle (OOM), through the pretarsal fibrofatty tissue and levator aponeurosis, to the pretarsal membrane (MAP method) as the linkage mechanism.

Results:
Tarsal height levels were higher than reported in many previous studies. In the supine position, all FPHs were higher than the tarsi. Eyelid creases using the MAP method are created below the superior tarsal edges at varying heights, accommodating individual patient requests while achieving well-formed creases and improved eyelid mechanics. The recovery was brief, and the results were long-lasting with a minimal failure rate.

Conclusions:
Tarsal heights and FPHs are not as low as previously thought, which could explain why many ‘classic’ surgeries encounter various issues. Our proposed MAP method for Asian double eyelid blepharoplasty allows conservative crease-height-adjustability with results that are dynamic, natural, and durable.
Differences in Clinical Profiles and Biologic Treatment Approaches for Autoimmune Rheumatic Diseases Across Regions in Mexico
Authors: Rivera Terán Vijaya , Saavedra Miguel Ángel , Colunga Pedraza Iris Jazmín , Vega Morales David , Irazoque Palazuelos Fedra , Carrillo Vázquez Sandra , Xibillé Friedmann Daniel , Castillo Ortiz Angel Alejandro , Torres Valdez Estefanía , Sicsik Ayala Sandra , Miranda Hernández Dafhne , Casasola Vargas Julio César , Muñoz Monroy Omar , Valdés Corona Luis Francisco , Mendieta Zerón Samara , Merayo Chalico Javier , Durán Barragán Sergio , Ramos Sánchez Azucena , Paz Viscarra Aleni , Zamora Tehozol Erick , Torres Jiménez Alfonso , Torres-Ruiz Jiram , Alpízar Rodríguez Deshiré 
Published: January 2025

Objective
Being Mexico a very diverse developing country, the access to health care varies among geographical regions. We aimed to assess the differences in clinical features and treatment prescription in 3 regions of Mexico using data from the Mexican Adverse Events Registry (BIOBADAMEX).

Methods
We included all BIOBADAMEX patients from 2016 to 2023, compared the prescription patterns, the sociodemographic, clinical, and treatment characteristics between the northern (NR), central (CR), and southern regions (SR), and addressed the treatment survival by calculating hazards ratios (HRs).

Results
A total of 1084 patients were included: 389 (35.9%) from the NR, 569 (52.5%) from the CR, and 126 (11.6%) from the SR. The most common diagnosis was rheumatoid arthritis (61.0%). Patients from NR had longer disease duration (p = 0.03); those from SR had higher BMI (p < 0.001), DAS28 (p < 0.001), BASDAI scores (p = 0.02), and used more frequently glucocorticoids (p < 0.001). Patients from CR had more comorbidities (p = 0.001) and more regularly used conventional DMARDs (p = 0.007). Among patients with at least 2 assessments (n = 441), treatment with bDMARDs and tsDMARDs was discontinued in 247 (56%), 53% due to lack of efficacy. There was no association between the country region and treatment survival, but the main factors related to treatment discontinuation were disease duration (HR, 0.9; 95% confidence interval, 0.6–0.9) and lack of response (HR, 1.4; 95% confidence interval, 1.2–1.7).

Conclusions
In Mexico, patients with rheumatic diseases show regional differences in their clinical features and prescription patterns, which may be related to regional disparities in health care access and sociodemographic characteristics.