bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bipartite-Tracking Quasi-Consensus of Nonlinear Uncertain Multi-Agent Systems: Neural Network-Based Adaptive State-Constraint Impulsive Control Approach
Authors: Xu Ziqiang , Li Yun , Zhan Xisheng , Yan Huaicheng 
Published: October 2022

Abstract
In the engineering application of multi-agent systems (MASs), the uncertain dynamic and the actuator saturation are inevitable. Considering these factors, the bipartite-tracking quasi-consensus of nonlinear uncertain MASs over signed graph is discussed in this paper. Two kinds of neural network-based adaptive state-constraint impulsive control protocols are proposed, where the communication instant between the leader and followers only takes place at some discrete time. Considering radial basis function neural networks (RBFNNs) having superior approximation ability, we design an adaptive weight updating strategy to compensate the uncertain nonlinear dynamic of the system. By means of linear matrix inequality (LMI), convex analysis, impulsive system theory and Lyapunov stability theory, we derive some simple sufficient conditions for the bipartite-tracking quasi-consensus under the assumption that the communication topology is structurally balanced. Further, we estimate the region of attraction of the error system between the leader and followers. Two simulation examples are also provided to show the effectiveness of the proposed protocols.
Nomogram Model for Screening the Risk of Frailty in Elderly Atrial Fibrillation Patients: A cross-sectional study
Authors: Lin Hairong , Sun Dingce , Xu Zhiying , Yuan Zhifang , Ding Xin , Lin Mei 
Published: October 2022

Abstract
Background
Frailty is common in atrial fibrillation(AF)patients, but its related risk factors need to be further investigated. Furthermore, a risk prediction model based on risk factors urgently needed to be established to remind risk among AF patients.
Purpose
This study aimed to explore the multiple risk factors of frailty in elderly patients with atrial fibrillation(AF) and then construct and validate a nomogram risk prediction model to remind frailty events in this population.
Methods
A total of 337 hospitalized patients over 60(average age: 69, 53.1% male)with AF in Tianjin Medical University General Hospital from November 2021 to August 2022 were recruited. Patients were assessed for frailty with the FRAIL scale and then assigned into the groups, robust, pre-frail, and frail. The Least absolute shrinkage and selection operator (LASSO) and the Ordinal regression were utilized to screen independent risk factors. Subsequently, gather the factors in a nomogram to predict the risk among the AF population. The concordance index (C-index) and calibration curves were utilized to evaluate the performance of the nomogram model.
Results
The prevalence of frail and pre-frail were 23.1% and 52.2% among AF patients, respectively. A total of six predictors for frailty were screened out containing age, gender, history of coronary heart disease, number of chronic diseases, sleep disruption, and mental health status. The C-index of internal and external validation for the nomogram model were 0.821(95%CI: 0.778–0.864; bias corrected C-index: 0.795) and 0.837(95%CI: 0.780–0.893; bias corrected C-index: 0.774), respectively, indicating its favourable discriminative ability. Both internally and externally validated calibration charts were highly consistent with the ideal curve, illustrating that the model had a good predictive ability.
Conclusion
Frailty was common in the AF population, and the nomogram model has a great discriminative and predictive probability which can identify frailty risk incidents in elderly AF patients.
Candidatus Alkanophaga archaea from heated hydrothermal vent sediment oxidize petroleum alkanes
Authors: Zehnle Hanna , Laso-Pérez Rafael , Lipp Julius , Teske Andreas , Wegener Gunter 
Published: October 2022

AbstractThe methyl-coenzyme M reductase (Mcr) enables archaea to produce and oxidize methane, critically impacting the global greenhouse gas budget. Recently cultured archaea activate short- and long-chainn-alkanes with divergent Mcr variants, termed alkyl-coenzyme M reductases (Acrs). Here, we probed the anaerobic oxidation of mid-chain petroleum alkanes at 70°C using oil-rich sediments from the Guaymas Basin. Incubations with alkanes from pentane to tetradecane produced active cultures. In these cultures, archaea of the genusCandidatusAlkanophaga activate the alkanes with Acrs and completely oxidize the alkyl groups to CO2.Ca.Alkanophaga form a deep-branching sister clade to the methanotrophs ANME-1 and are closely related to the short-chain alkane oxidizersCa.Syntrophoarchaeum. This suggests that multi-carbon alkane metabolism preceded methane metabolism in the class Syntrophoarchaeia.Ca.Alkanophaga shuttle the electrons from alkane oxidation to sulfate-reducingThermodesulfobacteria. The two partners form consortia that are potential key players in petroleum degradation in heated oil reservoirs.
Prevalence and impact of dental caries and consequences of non-treatment on the quality of life of schoolchildren.
Authors: Giacomin Angela , Miroski Bruna , Klein Daniele , de Vasconcelos Fernanda Maria Torres , Konrath Andrea , Cardoso Mariane , Bolan Michele 
Published: October 2022

Abstract
Background: Several oral alterations such as dental caries can affect the quality of life of children, adolescents and their families. The objective of the present study was to identify the prevalence of dental caries and the consequences of non-treatment and the impact on the quality of life of schoolchildren 8-10 years of age.
Methods: The sample was comprised of 1,315 schoolchildren belonging to 24 municipal schools. The prevalence of caries and the consequences of untreated caries were obtained by the DMFT/deft and PUFA/pufa indexes, respectively, and categorized in schoolchildren as: caries free, caries history, carious and consequences of untreated caries. Quality of life was assessed by the Child Perceptions Questionnaire (CPQ8-10). Data were analyzed descriptively and by logistic regression analysis with a 95% level of significance.
Results: The DMFT / deft was 1.43 (± 1.958) / 0.28 (± 0.693) and PUFA / pufa was 0.22 (± 0.689) / 0.01 (± 0.106) with a prevalence of 44 2% and 13.6%, respectively. The oral condition related to dental caries has an impact on the quality of life (p <0.001), children with caries (OR = 1.75; 95% CI: 1.301 to 2.367) and consequences of non- treatment (OR = 2.33; 95% CI: 1.599 to 3.418) is more likely to have a worse impact on the quality of life.
Conclusion: It is concluded that the prevalence of dental caries is 44.2%, and the consequence of untreated caries is 13.6%. The oral condition related to dental caries has an impact on the quality of life, dental caries and the consequences of untreated caries increase the chances of a negative impact.
Six-dimensional structured optical tweezers synthetized by rigid-body emulation
Authors: Shen Yijie , Zhu Liuhao , Tai Yuping , Li Hehe , Hu Huajie , Li Xinzhong , Cai Yangjian 
Published: October 2022

Abstract
Structuring light with more extended degrees of freedom (DoFs) and in higher dimensions is increasingly gaining traction and leading to breakthroughs such as super-resolution imaging, larger-capacity communication, especially ultraprecise optical trapping or tweezers. More DoFs when manipulating an object can access more maneuvers and radically increase maneuvering precision, which is of significance in biology and related microscopic detection. However, manipulating particles beyond the three-dimensional (3D) spatial manipulation by using current all-optical tweezers technology remains difficult. To overcome this limitation, we theoretically and experimentally present six-dimensional (6D) structured optical tweezers based on tailoring structured light emulating rigid-body mechanics. Our method facilitates the evaluation of the methodology of rigid-body mechanics to synthesize six independent DoFs in a structured optical trapping system, akin to six-axis rigid-body manipulation, including surge, sway, heave, roll, pitch, and yaw. In contrast to previous 3D optical tweezers, our 6D structured optical tweezers significantly improved the flexibility of the path design of complex trajectories, thereby laying the foundation for next-generation functional optical manipulation, assembly, and micromechanics.
Pre Exposure to Enriched Environment Alleviates Brain Injury after Ischemia-Reperfusion by inhibiting p38MAPK/STAT1 pathway
Authors: Shen Xin-Ya , Han Yu , Gao Zhen-Kun , Han Ping-Ping , Bi Xia 
Published: October 2022

Abstract
Background.
Stroke is one of the major diseases that endangers human health. It is widely reported that enriched environment (EE) can improve the neurological function in different brain injury models. Recently, relevant researches have indicated that MAPK pathway is closely related to the inflammatory response in nervous system related diseases. However, whether pre exposure to EE (EE pretreatment) has a preventive effect, and its mechanism are not clear. Therefore, this study aimed to determine the possible benefits and related mechanisms of EE in preventing brain injury after ischemia-reperfusion.
Methods.
Adult Sprague Dawley rats were kept in enriched or standardized environments for 21 days. Then the middle cerebral artery of rats was occluded for one hour and 30 minutes, and then reperfusion was performed. Then their neurological deficit score was evaluated. Cerebral edema, along with ELISA and protein quantities of p38MAPK, JNK, ERK, IL-1β, TNF-α, and co-localization of Iba1 were assessed. Changes in neuroinflammation and apoptosis were also detected in the penumbra cortex.
Results.
Our research showed that EE pretreatment significantly alleviated cerebral ischemia-reperfusion injury in rats. Including the reduction of brain edema and apoptosis, and the improvement of neurological scores. In addition, the protein level of p38MAPK was significantly down regulated in EE pretreatment group, and the downstream protein STAT1 had the same trend. In addition, immunofluorescence results showed that Iba1 in EE pretreatment group decreased, the ELISA results showed that the classical proinflammatory cytokines increased significantly, while anti-inflammatory cytokines in EE pretreatment group increased, and the same results were obtained by Western blot analysis.
Conclusion.
On the whole, our research demonstrated that EE pretreatment can have a protective effect on the organism by inhibiting the p38 MAPK / STAT1 pathway. Thus, EE can be one of the most promising means of disease prevention. Secondly, p38MAPK / STAT1 pathway may be a latent target for the prevention of ischemic stroke.
Uniportal video-assisted thoracoscopic surgery without drainage-tube placement for pulmonary wedge resection: a single-center retrospective study
Authors: Ahn Seha , Moon Youngkyu 
Published: October 2022

Abstract
Background
Uniportal video-assisted thoracoscopic surgery without drainage-tube placement has been demonstrated to be safe and feasible for select situations. The purpose of this study is to assess the demographic, baseline, and intraoperative characteristics of patients who developed residual pneumothorax after thoracic surgery without drainage-tube placement.
Methods
We reviewed the records of all patients who underwent pulmonary wedge resection via uniportal video-assisted thoracoscopic surgery without drainage-tube placement between May 2019 and May 2022. The decision to omit chest-tube drainage was originally made on a case-by-case basis, using internal criteria. Postoperative chest radiography was performed on the day of surgery, on postoperative day 1, at the first outpatient visit, and at 1 month after surgery.
Results
A total of 134 patients met the selection criteria; 23 (17.2%) had residual pneumothorax on chest radiography on postoperative day 1, and 5 (3.7%) had residual pneumothorax at the first outpatient visit. Only 1 patient (0.7%) had residual pneumothorax on chest radiography at 1 month after surgery; this patient did not require chest-tube insertion or any other intervention. The presence of partial pleural adhesions independently increased the risk for postoperative residual pneumothorax on chest radiography, whereas older patient age reduced the risk.
Conclusions
Uniportal video-assisted thoracoscopic surgery for pulmonary wedge resection without drainage-tube placement is both safe and feasible for carefully selected patients. Most patients with residual pneumothorax in our study experienced spontaneous resolution, and none required reintervention.
Nonlinear Rayleigh wave propagation in thermoelastic media in dual-phase-lag.
Authors: Youssef Aya A. , Amein Nehad K. , Abdelrahman Nora S. , Abou-Dina Moustafa S. , Ghaleb Ahmed F. 
Published: October 2022

Abstract
A model of generalized thermoelasticity within dual-phase-lag is used to investigate nonlinear Rayleigh wave propagation in a half-space of a transversely isotropic elastic material. It is assumed that the coefficient of heat conduction is temperature-dependent, a fact that plays an important role in the coupling behaviour analysis of thermoelastic and piezo-thermoelastic solids. Taking such a dependence into account becomes a necessity at higher temperatures, when the material properties can no longer be considered as constants. Normal mode analysis is applied to find a particular solution to the problem under consideration. A concrete case is solved under prescribed boundary conditions and tentative values of the different material coefficients. The results are discussed to reveal the effect of temperature dependence of the heat conduction coefficient, as well as the thermal relaxation times, on nonlinear Rayleigh wave propagation. All quantities of practical interest are illustrated in two-and three-dimensional plots. The presented results may be useful in the detection of the second harmonic amplitudes through measurements related to the propagating heat wave.
Harnessing Adaptive Bistable Stiffness Inspired by Hair- Cell-Bundle Structure in Human Cochlea
Authors: Yoon Jong-Yun , Kim Gi-Woo 
Published: October 2022

Abstract
This study presents an initial study on the adaptive bistable stiffness of hair cell bundle structure in a human cochlea and aims to harness its bistable nonlinearity that features a negative stiffness region. Typically, hair cell bundle structures inside the human auditory system comprise a conical bundle structure constituting multiple tiny long cylinders called Stereocilia. Their primary function is to send electrical impulse signals to the brain in response to the vertical oscillation produced by the travelling wave propagation on the basilar membrane of the cochlea and to shift the region of better sensitivity through their mechanical adaption capability. In this study, the harmonic balance method was employed to understand the amplifying of the movements of hair cells over broad frequency ranges, and hair cell’s dynamic behaviors induced by bistable stiffness characteristics are projected on phase diagrams, and Poincare maps concerning the bifurcation. In this study, we investigate the nonlinear frequency responses of the hair cell bundle structure, deducing that the transferred sound signals can be significantly amplified, as observed in the super- and subharmonic response regimes. This study offers promising potential engineering applications to harness adaptive bistable stiffness.
Genome wide association analysis for grain moisture content and dehydration rate on maize hybrids
Authors: Dong Yuan , Feng Zhiqian , Ye Fan , Li Ting , Li Guoliang , Li Zhoushuai , Hao Yinchuan , Zhang Xinghua , Liu Wenxin , Xue JiQuan , Xu Shutu 
Published: October 2022

Abstract
For mechanized maize production, a low grain water content (GWC) at harvest is necessary. However, as a complex quantitative trait, the genetic mechanism of GWC remains unclear, especially in hybrids. In this study, a hybrid population through two environments including 442 F1 was used for genome-wide association analysis of GWC and the grain dehydration rate (GDR), using the area under the dry down curve (AUDDC) as the index. Then, we identified 19 and 17 associated SNPs for GWC and AUDDC, including 10 co-localized SNPs, along with 64 and 77 pairs of epistatic SNPs for GWC and AUDDC, respectively. These loci could explain 11.39–68.2% of the total phenotypic variation for GWC and 41.07–67.02% for AUDDC at different stages, whose major effect was the additive and epistatic effect. By exploring the candidate genes around the significant sites, a total of 398 and 457 possible protein-coding genes were screened, including autophagy pathway and auxin regulation related genes, and five inbred lines with the potential to reduce GWC in the combined F1 hybrid were identified. Our research not only provides a certain reference for the genetic mechanism analysis of GWC in hybrids but also provides an added reference for breeding low-GWC materials.
NDVI, nutrient accumulation and yield of onion fertilized with amorphous silica in a semiarid setting in Brazil
Authors: Nascimento Clistenes Williams Araujo do , Barros Marcos Kleber Dias , Silva Fernando Bruno Vieira da , Lima Luiz Henrique Vieira , Silva Franklone Lima da , Veloso Venâncio de Lima , Silva Josévaldo Ribeiro , Lins Simone Aparecida da Silva 
Published: October 2022

Abstract
Purpose
Silicon (Si) can reduce abiotic stresses in plants and increase crop yield in semiarid climates. We aimed to assess the effect of an amorphous silica-based fertilizer (ASF) applied to soil on the yield, mineral nutrition, and health of an onion crop grown in northeast Brazil.
Methods
The ASF was applied at the rates of 0, 75, 125, 175, and 225 kg ha− 1. Yield and quality of bulbs as well as leaf concentrations of Si and nutrients were evaluated. Stress amelioration was assessed through Normalized Difference Vegetation Index (NDVI).
Results
ASF increased the yield of onions and enhanced the concentration of Si, N, P, K, Ca, Mg, B, Mn, Zn, and Cu in leaves. There was no ASF effect on bulb quality. NDVI indicated that applying 225 kg ha− 1 ASF to soil promoted healthier onion plants and the highest yield.
Conclusions
Silicon increased the yield of onions due to improved plant nutrition and stress amelioration.
Association between allostatic load and adverse outcomes among older patients with heart failure with preserved ejection fraction
Authors: Hao Benchuan , Chen Jianqiao , Cai Yulun , Li Huiying , Zhu Zifan , Xu Weihao , Liu Hongbin 
Published: October 2022

Abstract
Background
The present study aimed to investigate the association between allostatic load (AL) and adverse outcomes, including mortality and heart failure (HF) admission, among elderly male patients who had heart failure with preserved ejection fraction (HFpEF).
Methods
A prospective cohort study of 1111 elderly male patients with HFpEF, diagnosed between 2015 and 2019 and followed up through 2021. We constructed an AL measure using a combination of 10 biomarkers, including fasting glucose, hemoglobin, systolic blood pressure, diastolic blood pressure, heart rate, total cholesterol, triglycerides, highdensity lipoprotein cholesterol, neutrophil-to-lymphocyte ratio, and creatinine. The diagnosis of HFpEF was made according to the 2016 European Society of Cardiology guidelines. A Cox proportional hazards model was used to determine the associations between AL and adverse outcomes.
Results
In multivariate analysis, AL was significantly associated with increased risk of all-cause mortality (medium AL: adjusted hazard ratio [HR] = 2.75; 95% confidence interval [CI] 1.31–5.75; high AL: HR = 3.22; 95% CI 1.44–7.19; per-score increase: HR = 1.27; 95% CI 1.13–1.43), cardiovascular mortality (medium AL: HR = 3.42; 95% CI 1.16–10.13; high AL: HR = 4.14; 95% CI 1.27–13.43; per-score increase: HR = 1.28; 95% CI 1.07–1.53), non-cardiovascular mortality (medium AL: HR = 2.96; 95% CI 1.05–8.32; high AL: HR = 3.53; 95% CI 1.12–11.14; per-score increase: HR = 1.33; 95% CI 1.13–1.57), and HF admission (medium AL: HR = 2.32; 95% CI 1.10–4.87; high AL: HR = 3.03; 95% CI 1.33–6.92; per-score increase: HR = 1.24; 95% CI 1.10–1.40). Consistent results were found in multiple subgroup analyses.
Conclusions
A higher AL burden was associated with increased risk for poor prognosis in elderly men with HFpEF. AL relies on information that is easily obtained in regular physical examinations and can be assessed in various care and clinical settings to determine risk and help improve prognosis in patients with HFpEF.
Efficacy of Mirabegron in Medical Expulsive Therapy for Ureteral Stones: A Systematic Review and Updated Meta-analysis
Authors: Liu Qiang , Zhu Shuxia , Huang Chaoyou 
Published: October 2022

AbstractThe possibility of using mirabegron as a new medical expulsive therapy agent for ureteral stones has been studied owing to its relaxant effects on the ureteral smooth muscle. The objective of this study was to update the evidence regarding the efficacy of mirabegron in medical expulsive therapy for the management of ureteral calculi. We systematically searched PubMed, Cochrane library and Embase to collect the clinical trials from inception dates to August 2022. Meta-analysis and forest-plot figures were calculated with the software review manager v5.0. Six studies with 462 patients were eligible for inclusion. Mirabegron achieved significantly higher expulsion rate than control (pooled RR: 1.44, 95% CI: 1.12, 1.86; P = 0.004). A subgroup analyses showed that mirabegron has a significantly higher expulsion rate on stone sizes smaller than 5/6 mm (RR 1.4; 95% CI: 1.11–1.77; P = 0.005). The superior effect was not observed on stone sizes > 5/6 mm (RR 1.04; 95% CI: 0.80–1.35; P = 0.77). The pooled data showed no significant difference in the expulsion time between mirabegron and control group (MD: -0.53, 95% CI -5.77–4.71; P = 0.84). There was no significant difference between the mirabegron group and the control group in the episodes of renal colic (MD -0.18; 95% CI -0.39–0.02; P = 0.08). But patients receiving mirabegron had less analgesic consumption. No serious adverse events were reported with mirabegron treatment. This systematic review shows that mirabegron is an effective and safe medical expulsive therapy agent in patients with ureteral stones.
The evaluation of acute, sub-acute toxicity and safety of hydro-alcoholic leaf extract of Putranjiva roxburghii in rat
Authors: Chauhan Jayhind Kumar , Ayesha Safia , Rai Sangeeta , Sahu Alakh N , Dubey Pawan K , Tripathi Anima 
Published: October 2022

Abstract
Putranjiva rouxburghii is an herbal plant that has been used to improve female reproductive health in ancient Indian ayurveda based medicinal system. Despite the widespread use, no scientific evidence is available to support its safety. In this study, we evaluated the acute and sub acute toxicity of P. roxburghii hydro-alcoholic leaf extracts in rat animal model. In acute toxicity, healthy rats were given 2000mg/kg body weight of P.roxburghii leaf extract for 14 days. In a sub acute toxicity experiment, healthy rats were divided into four groups and group A was given plane water whereas, group B, C and D was given 100, 200 and 400 mg/kg bodyweight leaf extract for 28 days. At intervals of 7 days, bodyweight, feed consumption, water intake, biochemical, pathological and molecular parameters were evaluated. The dose 2000mg/kg bodyweight used in acute toxicity study showed there were no clinical signs of toxicity. The LD50 of the P.roxburghii extract was anticipated to be above 2000mg/kg. All experimental groups had no significant differences (P<0.05) in body weight changes, feed consumption, or water intake. The biochemical parameters results showed no significant differences between the experimental groups. The organ tissues were examined grossly and histopathological study, there were no significant difference found between untreated and test rats. Our in-vitro study suggest that P.roxburghii leaf extract exerts pro-apoptotic effect on endometrial primary cells which further confirmed by AO/PI staining. It is concluded that hydro-alcoholic extracts of P.roxburghii leaf are potentially safe and may use for the cure of reproductive disorders.