bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of renal function after adrenalectomy in patients with Cushing or subclinical Cushing syndrome
Authors: Kufukihara Ryohei , Takeda Toshikazu , Hakozaki Kyohei , Yasumizu Yota , Tanaka Nobuyuki , Matsumoto Kazuhiro , Morita Shinya , Kosaka Takeo , Mizuno Ryuichi , Asanuma Hiroshi , Miyashita Kazutoshi , Kurihara Isao , Oya Mototsugu 
Published: August 2022

PurposeThe postoperative course of renal function remains unclear in Cushing syndrome. We examined changes in renal function after adrenalectomy in patients with Cushing syndrome and attempted to identify predictors of renal impairment.MethodsThe study population comprised 76 patients who underwent adrenalectomy for Cushing and subclinical Cushing syndrome between 2001 and 2018. Renal function and other factors were evaluated pre‐operation, at 1 postoperative month, and 1 postoperative year. We defined a ≥10% decrease in the estimated glomerular filtration rate at 1 postoperative year as renal impairment, and predictors associated with this reduction were investigated. The relationship between renal function and steroid replacement after surgery was also examined.ResultsMean pre‐operative estimated glomerular filtration rate was 82.2 ml/min/1.73 m2. While mean estimated glomerular filtration rate was significantly lower at 1 postoperative month than the pre‐operative value (71.7 ml/min/1.73 m2 [89.1%], p < 0.001), no significant differences were observed between 1 postoperative year and pre‐operation (79.5 ml/min/1.73 m2 [97.6%], p = 0.108). Twenty‐six patients (34.2%) developed renal impairment. A multivariate analysis identified a low pre‐operative adrenocorticotropic hormone level as an independent predictor of renal impairment (odds ratio 6.30, p = 0.031). Among 43 patients with available records of steroid replacement history, 18 (41.9%) developed renal impairment. The ratio of patients with a reduced steroid replacement dose at 1 postoperative month was significantly lower among patients with renal impairment than those without (22.2% vs. 56.0%, p = 0.027).ConclusionsThe pre‐operative adrenocorticotropic hormone level was a predictor of renal function after adrenalectomy in patients with Cushing or subclinical Cushing syndrome.
Advance selling under uncertain supply and demand: a robust newsvendor perspective
Authors: Yu Hui , Yan Xiaoli 
Published: August 2022

AbstractConsidering the restriction of supply risk on optimal profit realization in advance selling, we discuss three selling strategies of a seller who produces and sells a seasonal product to a consumer under uncertain supply and demand: all advance selling, partial advance selling, and non‐advance selling. The robust newsvendor model is designed to solve the problem. Our results show that implementing an advance selling strategy is always beneficial from the demand uncertainty perspective to the seller. However, sellers should choose advance selling carefully from the standpoint of supply uncertainty: sellers will non‐advance selling under certain conditions. This condition is contingent on the market, capacity level, selling price, supply–demand correlation, consumer characteristics, and seller's pricing power. Interestingly, pricing power is the key driver to stimulate advance selling under supply uncertainty. In addition, the impact of supply and demand uncertainty and supply–demand correlation on these strategies are related to price discounts.
Utilization of a topical autologous blood clot for treatment of pressure ulcers
Authors: Landau Zvi , Whitacre Katie Lyn , Leewood Charles , Hawkins Jessie , Wachuku Chinenye D. 
Published: August 2022

AbstractManagement and treatment of pressure ulcers (PUs) are met with great difficulty due to various factors that cause vulnerability of the soft tissue such as location, limited mobility, increased friction and shearing forces, as well as other comorbidities that may delay or halt wound healing. The topical autologous blood clot therapy (TABCT) is a point‐of‐care treatment used as a blood clot to assist in recreating and repairing the extracellular matrix (ECM). The mechanism of action consists of reconstruction of the ECM by incorporating into the ulcer, providing protection from further external destruction, while assisting in advancement through the wound healing phases via interaction of necessary growth factors, mediators, and chemokines. This study aims to assess the efficacy of the TABCT in the treatment of PUs in comparison to standard of care (SOC) treatment. Twenty‐four patients, 18 years or older, with PUs ranging from stage 1 to 4, were included in this study. TABCT was created by using the patient's own peripheral blood in a point of care setting. Efficacy in percent area reduction (PAR) on weeks 4 and 12 with TABCT over SOC was assessed. Treatment using TABCT in PUs resulted in 77.9% of the patients achieving a 50% PAR on week 4. The mean PAR on week 12 was 96.23% with 45% of the wounds treated with TABCT achieving complete wound closure. TABCT exhibited efficacy in PAR of PUs. In addition, TABCT use prompted granulation tissue formation over vital structures, such as bone, which is often present in later stage PUs. The potential of bringing an affordable, cost‐effective, advanced biologic bedside treatment that is efficacious in resolution of these complex wounds has the potential to drastically reduce the burden of treatment on the health system.
Ontogenetic changes in cortical bone vascular microstructure in the domestic duck (Anas platyrhynchos) and ring‐necked pheasant (Phasianus colchicus)
Authors: Williams Katherine A. , Gostling Neil J. , Oreffo Richard O. C. , Schneider Philipp 
Published: August 2022

AbstractAge‐related changes in bone microstructure can inform our understanding the biology of both extant and fossil birds, but to date, histological work in birds, and particularly work using high‐resolution 3D imaging, has largely been restricted to limited growth stages. We used minimally destructive synchrotron radiation‐based X‐ray computed tomography to visualise and measure key morphological and histological traits in 3D across development in the domestic duck and ring‐necked pheasant. We use these measurements to build on the database of key reference material for interpreting bone histology. We found that growth patterns differed between the two species, with the ducks showing rapid growth in their lower limbs and early lower limb maturation, while pheasants grew more slowly, reflecting their later age at maturity. In the pheasant, both walking and flight occur early and their upper and lower limbs grew at similar rates. In the duck, flight and wing development are delayed until the bird is almost at full body mass. Through juvenile development, the second moment of area for the duck wing was low but increased rapidly towards the age of flight, at which point it became significantly greater than that of the lower limb, or the pheasant. On a microstructural level, both cortical porosity and canal diameter were related to cortical bone deposition rate. In terms of orientation, vascular canals in the bone cortex were more laminar in the humerus and femur compared with the tibiotarsus, and laminarity increased through juvenile development in the humerus, but not the tibiotarsus, possibly reflecting torsional vs compressive loading. These age‐related changes in cortical bone vascular microstructure of the domestic duck and pheasant will help understanding the biology of both extant and fossil birds, including age estimation, growth rate and growth patterns, and limb function.
We, campesinos: The potentials and pitfalls of agrarian populism in Colombia's agrarian strike
Authors: Sankey Kyla 
Published: August 2022

AbstractThis contribution aims to explore the potentials and pitfalls for the emergence of a popular agrarian movement capable of offering a progressive alternative to the far‐right. Taking the case of Colombia's national agrarian strike, the paper argues that food sovereignty can offer a mobilizing framework for a multiclass, antineoliberal agrarian coalition. However, the possibilities for building a counter‐hegemonic movement should be taken with more caution. An examination of the class differentiation between and within campesino movements reveals how the interests of certain groups may be prioritized over others. While agrarian populism may offer an important political strategy for building coalitions and framing demands, a closer class analysis points to limits to its transformative potential.
Artificial intelligence in melanoma: A systematic review
Authors: Zhang Shu , Wang Yuanzhuo , Zheng Qingyue , Li Jiarui , Huang Jiuzuo , Long Xiao 
Published: August 2022

AbstractBackgroundMelanoma accounts for the majority of skin cancer deaths. Artificial intelligence has been applied in many types of cancers, and in melanoma in recent years. However, no systematic review summarized the application of artificial intelligence in melanoma.AimsThis study aims to systematically review previously published articles to explore the application of artificial intelligence in melanoma.Materials & MethodsPubMed database was used to search the eligible publications on August 1, 2020. The query term was “artificial intelligence” and “melanoma.”ResultsA total of 51 articles were included in this review. Artificial intelligence technique is mainly used in the evaluation of dermoscopic images, other image segmentation and processing, and artificial intelligence diagnosis system.DiscussionArtificial intelligence is also applied in metastasis prediction, drug response prediction, and prognosis of melanoma. Besides, patients' perspectives of artificial intelligence and collaboration of human and artificial intelligence in melanoma also attracted attention. The query term might not include all articles, and we could not examine the algorithms that were built without publication.ConclusionThe performance of artificial intelligence in melanoma is satisfactory and the future for potential applications is enormous.
Maternal overweight and obesity and its associated factors and outcomes in human immunodeficiency virus (HIV)‐infected and HIV‐uninfected black South African pregnant women
Authors: Erasmus Christen R. , Chuturgoon Anil A. , Maharaj Niren R. 
Published: August 2022

AbstractAimThis study aimed to investigate various variables between maternal overweight and/or obesity versus normal‐weight pregnant black South African women living with and without human immunodeficiency virus (HIV).MethodsA cross‐sectional study design was employed. A total of 200 pregnant women were enrolled in the study, categorized according to body mass index (BMI) (kg/m2) into two groups: (1) overweight/obese (≥25 kg/m2) (n = 97); and (2) nonoverweight/nonobese (<25 kg/m2) (n = 103), where 90 were HIV‐infected and 110 were HIV‐uninfected. The differences between the maternal BMI categories were assessed using Fisher's exact t‐test and the χ2 test. Simple and multiple logistic regression analyses were used to determine factors associated with maternal overweight and obesity.ResultsMultiple logistic regression analysis showed that maternal age (odds ratio [OR]: 1.061; 95% confidence interval [CI] 1.008–1.117; p = 0.023) and gestational age (OR: 1.121; 95% CI 1.005–1.251; p = 0.041) were significantly associated with maternal overweight/obesity in both HIV‐infected and HIV‐uninfected. For maternal health outcomes, multiple logistic regression analysis showed that hypertensive disorders (OR: 0.273; 95% CI 0.124–0.601; p = 0.001) and anemia (OR: 2.420; 95% CI 1.283–4.563; p = 0.006) were significantly associated with maternal overweight/obesity in both HIV‐infected and HIV‐uninfected. The overweight/obese HIV‐infected participants (OR: 0.233; 95% CI 0.075–0.717; p = 0.011) had increased odds for developing hypertensive disorders compared to HIV‐uninfected overweight/obese participants (OR: 0.471; 95% CI 0.172–1.291; p = 0.143).ConclusionsMaternal overweight/obesity in both HIV‐infected and HIV‐uninfected pregnant black South African women was significantly associated with maternal age, gestational age, HPT disorders, and anemia. Maternal overweight/obesity decreased the odds for anemia, but increased the odds for the development of HPT disorders, especially in the HIV‐infected pregnant women.
Percutaneous ultrasound‐guided microwave ablation for treatment of hepatocellular carcinomas in dogs: four cases (2019‐2020)
Authors: Locatelli A. , Treggiari E. , Innocenti M. , Romanelli G. 
Published: August 2022

ObjectivesTo describe ultrasound‐guided microwave ablation as a minimally invasive treatment option for primary or metastatic hepatocellular carcinomas.MethodsFour client‐owned dogs underwent percutaneous ultrasound‐guided microwave ablation of three primary and one metastatic hepatocellular carcinoma, diagnosed on cytology/histopathology. In each case, multiple ultrasound‐guided thermal lesions were created in a 10 to 40 minutes ablation at 30 to 35 W. Real‐time monitoring was performed using 10 MHz diagnostic ultrasound transducers. The procedures were performed without complication and CT scans or abdominal ultrasounds were repeated immediately after. Patients were discharged on oral analgesia on the same day or 24 hours later.ResultsHepatocellular carcinomas were successfully ablated, which in some cases resulted in an improvement in clinical signs and laboratory values. The patients were followed up for a time ranging between 39 and 649 days and no evidence of disease progression was found. Three out of four patients are still alive at the time of writing.Clinical SignificanceIn these four patients, minimally invasive ultrasound‐guided microwave ablation was feasible and resulted in no immediate complications. Regular imaging follow‐up is recommended after the procedure and further studies on microwave ablation are warranted to establish its effectiveness in dogs with hepatocellular carcinomas.
Developmental evidence for parental conflict in driving Mimulus species barriers
Authors: Sandstedt Gabrielle D. , Sweigart Andrea L. 
Published: August 2022

Summary

The endosperm, a tissue that nourishes the embryo in the seeds of flowering plants, is often disrupted in inviable hybrid seeds of closely related species. A key question is whether parental conflict is a major driver of this common form of reproductive isolation.

Here, we performed reciprocal crosses between pairs of three monkeyflower species (Mimulus caespitosa, Mimulus tilingii, and Mimulus guttatus). The severity of hybrid seed inviability varies among these crosses, which we inferred to be due to species divergence in effective ploidy. By performing a time series experiment of seed development, we discovered parent‐of‐origin phenotypes that provide strong evidence for parental conflict in shaping endosperm evolution.

We found that the chalazal haustorium, a tissue within the endosperm that is found at the maternal–filial boundary, shows pronounced differences between reciprocal hybrid seeds formed from Mimulus species that differ in effective ploidy. These parent‐of‐origin effects suggest that the chalazal haustorium might act as a mediator of parental conflict, potentially by controlling sucrose movement from the maternal parent into the endosperm.

Our study suggests that parental conflict in the endosperm may function as a driver of speciation by targeting regions and developmental stages critical for resource allocation and thus proper seed development.
Effects of Chemical Sterilization and Gamma Irradiation on the Biochemical and Biomechanical Properties of Human Tendon Allografts In Vitro Study
Authors: Zhang Hao‐ran , Xu Ming‐you , Zhang Lei , Zhang Hao , Yang Li , Liu Jie , Zhang Jing‐yu , Hu Yong‐cheng 
Published: August 2022

ObjectivePre‐implantation sterilization procedures for tendons are important measures to reduce the risk of disease transmission, however these procedures may compromise tendon microarchitecture and biomechanical properties to varying degrees. We explore the effects of different sterilization procedures on the micro‐histology, biomechanical strength and biochemical properties of human tendon allografts in vitro study.MethodsThe tendon allografts were harvested from cadaveric donors after the donors were serologically screened by antibody or nucleic acid testing of infectious agents. All samples were divided into five groups, which were fresh‐frozen group (control group), 15 kGy gamma irradiation group, 25 kGy gamma irradiation group, 70% ethanol group, and peracetic acid‐ethanol group. Each group included 10 tendons for testing. Histological staining and transmission electron microscopy were applied to observe the internal structure and arrangement of tendon collagen fibers, while the machine learning classifier was trained to distinguish the darker cross‐sections of collagen fibers and brighter backgrounds of the electron micrograph to detect the distribution of diameters of tendon collagen fibers. The viscoelasticity, mechanical properties and material properties of tendon allografts were examined to detect the influence of different intervention factors on the biomechanical properties of tendons.ResultsHistological staining and transmission electron microscopy showed that the structure of fresh‐frozen tendons was similar to the structures of other experimental groups, and no obvious fiber disorder or delamination was observed. In the uniaxial cyclic test, the cyclic creep of 25 kGy irradiation group (1.5%) and peracetic acid‐ethanol group (1.5%) were significantly lower than that of the control group (3.6%, F = 1.52, P = 0.039) while in the load‐to‐failure test, the maximum elongation and maximum strain of the peracetic acid‐ethanol group were significantly higher than those of the control group (F = 4.60, P = 0.010), and there was no significant difference in other biomechanical indicators. According to the experimental results of denatured collagen, it could be seen that no matter which disinfection procedure was used, the denaturation of the tendon sample would be promoted (F = 1.97, P = 0.186), and high‐dose irradiation seemed to cause more damage to collagen fibers than the other two disinfection procedures (296.2 vs 171.1 vs 212.9 μg/g).ConclusionBiomechanical experiments and collagen denaturation tests showed that 15 kGy gamma irradiation and 70% ethanol can preserve the biomechanical strength and biochemical properties of tendons to the greatest extent, and these two sterilization methods are worthy of further promotion.
The Sense of Scriptural Authority
Authors: Kim H. Jong 
Published: August 2022

AbstractStarting with the puzzlement M O.C. Drury and Rush Rhees felt about Wittgenstein's admonition that believers ought not to pick and choose among the passages of the bible, this paper seeks to clarify the sense of scriptural authority in the Judeo‐Christian traditions. This paper argues that (1) picking and choosing, imposing certain criteria external to the Scripture, is grammatically constitutive of accepting the authority of Scripture and (2) such a picking and choosing is guided by a tradition and its grammar. It notes that Wittgenstein's stance on Scripture is itself based on (1) and (2).
Stakeholders’ perceptions of barriers and facilitators for dental and mental health referrals of HIV/AIDS clinic patients
Authors: Bhanat Namrata , McIntosh Scott , Khanal Prasida , Ghosh Sucharu , Gajendra Sangeeta 
Published: August 2022

AbstractIntroductionPersons living with HIV/AIDS (PLWHA) are understudied and underserved with respect to both dental and mental health services. The coexistence of psychiatric and dental problems in PLWHA leads to more complex diagnostic assessments and treatments compared to the general population. The aim of the present study was to identify relevant themes from the perspectives of important stakeholders regarding the barriers to and facilitators of patient referral to these services.MethodSemi‐structured Key Informant Interviews (KIIs) were conducted with nine program directors and other key staff from New York State HIV clinics to examine barriers to and facilitators of successful dental and mental health referrals and factors that affect patient motivation.ResultsPrimary themes crystalized around dental and mental health referral, subject knowledge and perspective, patient barriers, and strategies to overcome barriers. Identified barriers included mental health and HIV status stigma, social determinants of health, fear, disconnectedness, and inconsistent access for dental care. Facilitators identified included case management, integrated one‐stop‐shop care, and interprofessional awareness and collaboration. Potential patient motivators included process improvement strategies such as transportation support, case management, incentives, and building trust.ConclusionSpecific strategies to facilitate patient motivation such as care coordination and interprofessional collaboration is useful for improving dental and mental health referrals.
Empowering girls in STEM: Impact of the girls meet science project
Authors: Yabas Defne , Kurutas Busra Sumeyye , Corlu Mehmet Sencer 
Published: August 2022

AbstractGender equity is a critical agenda for Science, Technology, Engineering and Mathematics (STEM) education to increase women involvement in the STEM pathway. Our study is about the impact of a project in which all‐girl teams participated to an educational robotics program. We used quantitative and qualitative data to determine the impact and understand the girls' program experiences. After the participation of the program, the mean scores have increased in interest in STEM, interest in STEM careers, STEM identity, and understanding of STEM scales. The groups underlined their problem solving and group work experiences, as well as their excitement and motivation related with the STEM activities.
Systematic Review and Classification of the Engineering for Global Development Literature Based on Design Tools and Methods for Social Impact Consideration
Authors: Armstrong Andrew G. , Suk Hailie , Mabey Christopher S. , Mattson Christopher A. , Hall John , Salmon John L. 
Published: August 2022

AbstractWhile many tools and methodologies for assessing social impact exist and are used in the social science and global development fields, there is a lack of standard methods for considering the broader social impact of products in the engineering community. Some reasons these methods are not as widely used in the engineering community include designers not being aware of the methods, or methods not being widely applicable. The purpose of this research is to help designers and researchers find relevant design tools and methods for implementing social impact considerations. This is done through the classification of 374 papers in the Engineering for Global Development (EGD) literature along several dimensions including method purpose, industry sector, social impacts considered, sustainable development goals, paper setting, and data inputs required. This article describes how designers and researchers can use this set of classified papers to locate relevant design tools and methods to improve social impact considerations in their work.