bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chinese herbal medicine is associated with higher body weight reduction than liraglutide among the obese population: A real-world comparative cohort study
Authors: Liao Yu-Ning , Chen Hsing-Yu , Yang Ching-Wei , Lee Pai-Wei , Hsu Chiu-Yi , Huang Yu-Tung , Yang Tsung-Hsien 
Published: September 2022

Introduction: In Taiwan, many people receive Chinese herbal medicine (CHM) as an alternative choice to help control body weight. However, the clinical effectiveness of CHM on weight control has not been well studied, while potential risks and adverse effects are still unknown. The aim of our study is to find out a safe and efficient treatment model of CHM for weight control compared to liraglutide in a real-world setting.Methods: we retrospectively analyzed obese subjects [body mass index (BMI)≧25 kg/m2] from Chang Gung Research Database (2013–2018). We evaluated the effect on body weight and BMI changes in obese groups receiving CHM or western medicine (WM, represented liraglutide) within 180 days. The proportion of subjects who achieved 5 and 10% weight reduction was calculated as well. Furthermore, the potential adverse events were analyzed during the study period. Overlap weighting was used to balance the baseline differences between CHM and WM groups.Results: The full cohort comprised 1,360 participants: 701 in the CHM group and 659 in the WM group. At baseline, the CHM group was younger (42.75 ± 12.12 years old in CHM vs. 52.31 ± 11.7 years old in WM, p-value &lt;0.001) and has more female subjects (77.6% in CHM vs. 53.0% in WM, p-value &lt;0.001). On the other hand, CHM users had lower body weight (79.83 ± 15.66 kg vs. 84.68 ± 17.14 kg, p-value &lt;0.001) and BMI (30.58 ± 5.20 vs. 32.84 ± 6.95, p-value &lt;0.001). At day 180, CHM users lost more body weight (−4.5 ± 4.07 kg vs. −2.15 ± 4.05 kg, p-value &lt;0.001) and higher reduction in BMI (−1.77 ± 1.73 vs. −0.9 ± 2.14, p-value &lt;0.001). A total of 53.21% (n = 373) CHM users lost at least 5% of body weight (22.46% for WM users, p-value &lt;0.001), and 18.97% (n = 132) lost at least 10% of body weight (4.55% for WM users, p-value &lt;0.001). The benefit remained consistent with and without overlap weighting. For adverse events, 18 cases of hypertension occurred in 659 subjects in the WM group (2.7%) in comparison to 1 of 701 subjects in the CHM group (0.1%).Conclusion: CHM led to clinically meaningful weight loss without serious adverse events in a real-world setting. Further clinical trials are warranted to validate this result.
QishenYiqi dripping pill protects against myocardial ischemia/reperfusion injury via suppressing excessive autophagy and NLRP3 inflammasome based on network pharmacology and experimental pharmacology
Authors: Li Meng , Wang Yueyao , Qi Zhongwen , Yuan Zhuo , Lv Shichao , Zheng Yawei , Yan Zhipeng , Wang Mingyang , Fu Huanjie , Fan Xinbiao , Ji Nan , Liu Ming , Fang Zhuyuan 
Published: September 2022

Background: Myocardial ischemia/reperfusion (I/R) injury is associated with multiple serious clinical manifestations. Autophagy is upregulated in a short period of ischemia and further enhanced during reperfusion phase, which was considered as a “double-edged sword” in the pathological process of myocardial I/R injury. In addition, NLRP3 inflammasome triggers myocardial inflammatory response, which leads to cardiomyocyte death via pyroptosis and promotes subsequent myocardial remodelling. Qishen Yiqi Dripping Pill (QSYQ) has been recognized as a potential protective agent of cardiovascular diseases.Objective: We predicted the bioactive compounds, targets and pathways of OSYQ intervening on myocardial I/R injury by network pharmacology. Furthermore, we investigated the effect of QSYQ on myocardial I/R injury and explored its underlying mechanism via autophagy and NLRP3 Inflammasome.Methods: Bioactive compounds, targets of QSYQ and relevant targets of myocardial I/R injury were collected from public databases. The protein-protein interaction network, Gene ontology and KEGG pathway enrichment analysis were carried out to screen the key compounds, target genes, functional annotation and pivotal pathways. Molecular docking was used to validate the binding association between target genes and key bioactive ingredients. Furthermore, sixty SD rats were randomized into four groups: 1) sham, 2) model, 3) captopril and 4) QSYQ pretreatment (14 days before and after surgery). Each arm was subjected to ischemia/reperfusion surgery except sham arm (30 min coronary ligation, then reperfusion). Left ventricular (LV) function were evaluated and the hearts were used to evaluate size of myocardial infarction, cardiomyocyte fibrosis, and myocardial autophagosomes.Results: The network pharmacology revealed the mechanism of QSYQ intervening on myocardial I/R injury might be related to NOD-like receptor signaling pathway, PI3K-Akt signaling pathway, autophagy-animal, etc., Molecular-docking suggested the core target proteins had good binding association with bioactive compounds of QSYQ. The experiment confirmed that QSYQ attenuated myocardial infarct size, decreased inflammatory infiltration and collagen fiber deposition and alleviated the autophagosome and myocardium ultrastructure injury, leading to LV systolic function improvement. The possible mechanism of cardioprotection was due to regulating autophagy-related proteins, activating PI3K/Akt-mTOR signaling pathway, and inhibiting activation and assembly of NLRP3 inflammasome.Conclusion: QSYQ ameliorated myocardial I/R injury via suppressing excessive autophagy and NLRP3 Inflammasome.
Electronic global-shutter one-thin-film-transistor active pixel sensor array with a pixel pitch of 50 μm and photoconductive gain greater than 100 for large-area dynamic imaging
Authors: Hu Yunfeng , Xu Yangbing , Liu Jinming , Qi Yihong , Wang Kai 
Published: September 2022

In large-area dynamic imaging, an active pixel sensor (APS) is proposed. However, there is a trade-off between signal-to-noise ratio (SNR) and spatial resolution. To resolve this, a 256 × 256 active pixel image sensor array based on a 3-D dual-gate photosensitive thin-film transistor (TFT) is presented in this work, with a pixel pitch of 50 μm, pixel fill factor of 63%, photoconductive gain of 102–104 and spatial resolution of 505 ppi. An electronic global shutter is enabled by dual-gate biasing without additional a shutter TFT. Such an array is capable of dynamic imaging at a frame rate of 34 Hz.
Stable soliton dual-microcomb generation via sideband thermal compensation for spectroscopy
Authors: Miao Runlin , Yin Ke , Zhang Chenxi , Yu Zhuopei , Cheng Xiang’ai , Jiang Tian 
Published: September 2022

Microcombs—generated by coherently pumping nonlinear microresonators—have emerged as a state-of-the-art scheme at the chip scale. Dual-comb spectroscopy (DCS) technology further takes advantage of the miniature system, and has been demonstrated as a powerful tool for real-time and broadband optical sampling of molecular spectra. Here, a novel soliton dual-microcomb generation method by rapid frequency sweep and sideband thermal compensation is put forward, and dual-microcomb optical spectra range beyond 200-nm has been successfully demonstrated in two microresonators with moderate quality factors. Compared to the dual-microcomb with a weak thermal compensation effect, the demonstrated dual-microcomb shows much lower-noise RF beat notes (&lt;10 kHz) and smaller Allan deviations (1.0 × 10–4 at 1 ms) by increasing sideband power. Moreover, the dual-microcomb has been utilized in the gas absorption detection of H12CN for demonstration with high signal-to-noise ratios (SNRs) and fast acquisition rates. This work also lays a technical foundation for other dual-microcomb applications of ranging and microwave photonics.
Comparison of the acute physiological and perceptual responses between resistance-type and cycling high-intensity interval training
Authors: Mao Jun , Wang Tao , Zhang Li , Li Qing , Bo Shumin 
Published: September 2022

Purpose:The purpose of the present study was to compare the acute physiological and perceptual responses between resistance-type high-intensity interval training (R-HIIT)and cycling high-intensity interval training (C-HIIT).Methods:Twelve healthy and active men randomly performed C-HIIT and R-HIIT. The C-HIIT protocol was performed on a cycle ergometer and consisted of ten 60 s working intervals at 90% PPO separated by a 60 s active recovery at 25% PPO. The R-HIIT protocol consisted of ten 60 s working intervals (barbell back squat with a load of 20% bodyweight, maximum 30 reps) separated by 60 s passive recovery period in an unloaded standing position. Oxygen consumption (V˙O2), heart rate (HR), energy expenditure (EE) and rating of perceived exertion (RPE) were measured during exercise. Blood lactate concentration (Blac), serum testosterone and cortisol, and heart rate variability (HRV) were measured before and after exercise.Results:Peak (p&lt; 0.05) and averageV˙O2(p&lt; 0.001), aerobic (p&lt; 0.001) and total EE (p&lt; 0.05) were higher during C-HIIT compared to R-HIIT. Blac after exercise (p&lt; 0.05) and anaerobic glycolytic EE (p&lt; 0.05) during exercise were higher in R-HIIT compared to C-HIIT. No differences (p&gt; 0.05) in peak and average HR, serum testosterone and cortisol, HRV, and RPE responses were observed between C-HIIT and R-HIIT.Conclusion:The R-HIIT protocol can elicit similar cardiovascular, hormones, and perceptual responses as C-HIIT but with a higher contribution to the anaerobic glycolysis energy system. In contrast, C-HIIT is superior to R-HIIT for increasing oxygen consumption during exercise. Therefore, the two types of HIIT may lead to different metabolic and neuromuscular adaptations.
Assessing the needs and perspectives of patients with obesity and obstructive sleep apnea syndrome following continuous positive airway pressure therapy to inform health care practice: A focus group study
Authors: Rapelli Giada , Pietrabissa Giada , Angeli Licia , Bastoni Ilaria , Tovaglieri Ilaria , Fanari Paolo , Castelnuovo Gianluca 
Published: September 2022

ObjectiveThis study aims to investigate the lived experience in patients with obstructive sleep apnea syndrome (OSAS) and comorbid obesity following after continuous positive airway pressure (CPAP) therapy made with the disease the device, and to identify barriers and facilitators to the use of CPAP to improve rehabilitation provision and aid in disease self-management.MethodsQualitative research was conducted using three focus groups with a representative sample of 32 inpatients (37% female) undergoing a 1-month pulmonary rehabilitation program at the IRCSS Istituto Auxologico Italiano San Giuseppe Hospital, Verbania, Italy. The focus groups were recorded on tape, and contemporaneous notes were made. The tapes were transcribed verbatim, and Interpretative Phenomenological Analysis was used to develop themes.ResultsSix main themes were extracted: (1) Living the diagnosis as a shock; (2) You should not sleep on it: the importance of prevention; (3) The adjustment to CPAP; (4) Barriers and facilitators to the use of CPAP; (5) Three in a bed; and (6) The relationship with the healthcare system.ConclusionResults of this study suggest potential avenues for interventions to increase adherence to CPAP, including the provision of information and continued support. Individual counseling providing strategies aimed at helping the person to cope with the emotional problem and relational difficulties associated with the use of CPAP, and at strengthening self-efficacy and self-management skills are also encouraged for optimal care during the rehabilitation program.
Is aripiprazole similar to quetiapine for treatment of bipolar depression? Results from meta-analysis of Chinese data
Authors: Tao Hejian , Wang Jiawei , Shen Dong , Sun Fengli , Jin Weidong 
Published: September 2022

ObjectiveTo study the similarities and differences in the clinical efficacy of aripiprazole and quetiapine in Chinese patients with bipolar depression through meta-analysis. Additionally, to provide evidence of aripiprazole in treatment for bipolar depression.MethodsWe searched Chinese literature related to the study of aripiprazole and quetiapine in treatment for bipolar depression, among which results such as comments, letters, reviews, and case reports were excluded. The clinical efficacy between aripiprazole and quetiapine was synthesized and discussed.ResultA total of 1,546 subjects were included in 17 studies. The random effect model was used to review the data by RevMan 5.2. The results showed that there was no significant difference in the remission rate between patients treated with aripiprazole and quetiapine evidenced by the scale used to evaluate the patients being treated for bipolar depression (221/501 vs. 193/501, Z = 1.12, P = 0.26). But the results also showed that the remission rate of aripiprazole with lithium carbonate was significantly higher than quetiapine with lithium carbonate in the treatment of bipolar depression (111/232 vs. 69/232, Z = 3.92, P &lt; 0.0001). The results showed that the effective rate of aripiprazole was similar to quetiapine (426/572 vs. 386/572, Z = 2.70, P = 0.007). Overall, there was no difference in the Hamilton Rating Scale for Depression (HAMD) score between patients treated with aripiprazole and quetiapine (Z = 1.68, P = 0.09). The results also show that the drop-out rate of aripiprazole was similar to quetiapine in the treatment of patients with bipolar depression (Z = 1.80, P = 0.07).ConclusionAs an atypical antipsychotic, aripiprazole may be similar to quetiapine for treating bipolar depression with similar drop-out and higher remission rates when combined with lithium carbonate. However, the results of this study need to be read with caution given the poor quality of collected/analyzed literature.
Prevalence of overweight/obesity and associated factors among under-five children in Ethiopia: A multilevel analysis of nationally representative sample
Authors: Gebremichael Mathewos Alemu , Mengesha Melkamu Merid , Hailegebreal Samuel , Abdulkadir Hanan , Arja Asrat , Wolde Biruk Bogale 
Published: September 2022

BackgroundChildhood overweight and obesity are emerging public health challenges of the twety-first century. There was a 24% increase in the number of overweight children under the age of 5 years in low-income countries. Despite the significant risk of childhood overweight/obesity for non-communicable diseases, premature death, disability, and reproductive disorders in their adult life, little attention has been given. Therefore, we aimed to assess the prevalence of overweight/obesity and associated factors among under-five children.MethodsThis study was conducted using data from a nationally representative sample of the 2019 Ethiopia Mini Demographic and Health Survey (EMDHS). The Mini EDHS was a community-based cross-sectional study that covered all the administrative regions of Ethiopia. The data collection was conducted between March 21, 2019 and June 28, 2019. Both descriptive and analytic findings were produced. The overweight/obesity was measured by the weight-for-height (WFH) index, more than two standard deviations (+2 SD) above the median of the reference population based on the BMI Z-score. To identify significantly assoResultsA total of 5,164 under-five children were included in this study cited factors of overweight/obesity, a multilevel binary logistic regression model was fitted to account for the hierarchical nature of the data. Adjusted odds ratio (aOR) with a corresponding 95% confidence interval (CI) was reported to show the strength of association and statistical significance. The overall prevalence of overweight/obesity was 2.14% (95% CI: 1.74–2.53). The odds of overweight/obesity was higher among children aged &lt;6 months (aOR = 5.19; 95% CI: 2.98–9.04), 6–24 months (aOR = 1.97; 95% CI: 1.18–3.29), delivered by cesarean section (aOR = 1.75; 95% CI: 1.84–3.65), living in Addis Ababa city (aOR = 2.16; 95% CI: 1.59–7.81), Oromia region (aOR = 1.93; 95% CI: 1.71–5.24), having mothers with the age 40–49 years (aOR = 3.91; 95% CI: 1.90–16.92), uses traditional contraceptive methods (aOR = 2.63; 95% CI: 1.66–10.47) and households headed by male (aOR = 1.71; 95% CI: 1.84–3.48).ConclusionThis study showed that the prevalence of overweight/obesity among under-five was low in Ethiopia. There were several factors that affect childhood overweight/obesity including child age, maternal age, mode of delivery, sex of head of household, contraception use, and geography of residence. Therefore, strategies to reduce childhood overweight and obesity should consider an identified multitude of contributing factors.
The impact of comprehensive public hospital reforms on the direct medical cost of inpatients with coronary heart disease
Authors: Liu Liming , Xu Yue , Yu Jingfei , Man Xiaowei , Jiang Yan , Zhao Liying , Cheng Wei 
Published: September 2022

ObjectivesTo curb the unreasonable growth of medical expenses and reduce the burden of medical treatment, Beijing launched two rounds of comprehensive reform of public hospitals. In the two reforms, the addition of drugs and consumables was canceled successively. This study compared the changes in the direct medical cost of inpatients with coronary heart disease (CHD) in the three stages of two comprehensive public hospital reforms in Beijing and provides data support for health reform policies.SettingCHD diagnosis and treatment data were extracted from the Hospital Information System (HIS) of 33 public hospitals. The total amount and composition of the direct medical expenses of CHD inpatients in the three stages were calculated. Interrupted time series analysis was used to study the instantaneous changes and trend changes in the three stages.ParticipantsThe data were obtained from the HIS system of 33 public hospitals above the second level in Beijing. A total of 66,647 medical and diagnosis records and 24,371,139 charge detail records were included.ResultsAfter the two reforms, the total cost for CHD inpatients with most clinical classifications and treatment methods decreased. The proportion of drug and consumable costs decreased significantly, whereas the proportion of medical consultation service costs increased. Drug-treated patients were mainly affected by the instantaneous reforms, percutaneous coronary intervention-treated patients were simultaneously affected by instantaneous and trending effects, and coronary artery bypass graft-treated patients were mainly affected by the reform trend.ConclusionThe overall change in the direct medical cost of CHD inpatients was consistent with the goal of the comprehensive medical reform of public hospitals in Beijing, which is “total control and structural adjustment.”
Healthcare quality and safety assessment based on annual scorekeeping
Authors: Liang Guo-Mo , Xie Wen-Chao , Gan Mei , Gao Jiao-Wei , Liang Qing , Zeng Zhi-Yu 
Published: September 2022

ObjectiveTo explore the practice of medical quality and safety evaluation system based on annual score under the background of establishing modern hospital management system and strengthening national public hospital performance evaluation.MethodsStatistical analysis was used to study the improvement of medical quality and safety in hospitals after the implementation of score evaluation, and the existing problems were analyzed according to the actual situation and related requirements.ResultsThe hospital's medical quality and safety evaluation system ran smoothly, the evaluation indexes could be implemented, and the evaluation results were used properly. The improvement of hospital medical quality and operation efficiency has achieved good results.ConclusionThe evaluation system of medical quality and safety for physicians and medical technicians based on annual score can achieve the whole process, all-round, personalized and information-based evaluation, and promote the high-quality development of hospitals. It is necessary to further improve the range of evaluation and carry out the evaluation of the evaluation system by relevant personnel.
Economic evaluation of margetuximab vs. trastuzumab for pretreated ERBB2-positive advanced breast cancer in the US and China
Authors: Tang Zhiyuan , Xu Xin , Gao Jie , Chen Ling , Zhu Qiuyan , Wang Jinli , Yan Xiaoyu , Chen Bohua , Zhu Yumei 
Published: September 2022

ObjectiveTo assess the economic evaluation of margetuximab plus chemotherapy over trastuzumab plus chemotherapy for women with pretreated ERBB2-positive advanced breast cancer in the United States (US) and China.MethodsBased on the SOPHIA trial, a three-state Markov model was developed to compare the cost and efficacy of margetuximab to trastuzumab for previously treated women with ERBB2-positive advanced breast cancer. The model inputs were derived from existing literature and the US life table. Primary outcomes included lifetime costs in US dollars, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratio (ICER). Deterministic and probabilistic sensitivity analyses were conducted to evaluate the impact of uncertainty.ResultsThe base case analyses demonstrated that margetuximab plus chemotherapy had an increasing cost of $68,132 and $20,540 over trastuzumab plus chemotherapy in the US and China, respectively, with a gain of 0.11 and 0.09 QALYs both favored margetuximab. The ICERs for two treatment strategies were $260,176 in the US and $630,777 in China, resulting in a poor cost-effectiveness at their respective threshold of willingness to play. One-way sensitivity analyses showed that the results to be most sensitive to the price of margetuximab and that of trastuzumab. And an 11 and 82% price reduction of margetuximab would make this regimen cost-effective in the US and China, respectively.ConclusionIn the US and China, margetuximab plus chemotherapy is not likely to be cost-effective for women with pretreated ERBB2-positive advanced breast cancer, whereas price reduction effectively improves insufficient cost-effectiveness.
Development and validation of a novel short-form nutrition literacy measurement tool for Chinese college students
Authors: Mo Guangju , Han Siyue , Gao Tianjing , Sun Qing , Zhang Min , Liu Huaqing 
Published: September 2022

ObjectivesTo develop and validate a short-form nutrition literacy (NL) assessment tool for Chinese college students based on a 43-item NL measurement scale.MethodsTo develop and validate short-form NL scale, 1359 college students were surveyed, the data were analyzed using exploratory factor analysis, linear regression analysis, Item analysis, confirmatory factor analysis, and Pearson correlation.ResultsThe 12-item short-form NL scale (NL-SF12) was developed using factor analysis and regression analysis, which accounted for 96.4% of the variance. The correlation coefficient between the NL-SF12 and NL-43 was 0.969, indicating satisfactory criterion-related validity. The NL-SF12 had a Cronbach's α of 0.890, suggesting strong internal consistency reliability, and content validity index was greater than 0.9, indicating that each domain accurately reflects the connotation of nutrition literacy. The model–data fit and convergent validity of the confirmatory factor analysis results were both good.ConclusionThe NL-SF12 is an effective measurement tool with a good reliability and acceptable validity to assess comprehensively NL for college students, and is applicable to quick, widespread use in population study and practice with low respondent burden.