bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and synthesis of novel lanthanide MOFs by unique in situ organic and inorganic reactions
Authors: Yoon Jung Heum , Lee Woo Ram , Lee Jeong Tae , Song Jeong Hwa , Lee Giseong , Lim Kwang Soo 
Published: August 2022

AbstractFour novel metal–organic frameworks (MOFs), H3O[Ln(Ox)1.5(formate)] (Ln = Tb (1), Dy (2), Ho (3), Er (4), Ox = oxalate) were synthesized, and their structures and properties were analyzed. They were prepared by solvothermal reaction under acidic condition with structure‐directing agents (H4dobpdc; 4,4′‐dihydroxy‐[1,1′‐biphenyl]‐3,3′‐dicarboxylic acid) and the corresponding Ln metal ion(s). Single‐crystal X‐ray diffraction analysis revealed that 1 and 2 (Group I) are isostructural as Cmca space group to 3 and 4 (Group II) as Pnma space group, respectively. This result probably comes from the change in structure according to the size of the lanthanide metal. TGA showed that the framework is thermally stable up to about 300 °C for all 1–4. Furthermore, we measured N2 adsorption at 77 K and CO2 adsorption at 195 K, and compound 2–4 had a type I adsorption isotherm graph and adsorbed CO2. In the study, we prepared and characterized four novel Ln‐MOFs, H3O[Ln(Ox)1.5(formate)] (Ln = Tb (1), Dy (2), Ho (3), Er (4), Ox = oxalate) by an unique in situ synthetic method.
New quantification method for monitoring 18 l‐amino acids levels in schizophrenic patients by high‐performance liquid chromatography coupled to tandem quadrupole mass spectrometer
Authors: Kaddah Mohamed M. Y. , Ali Heba M. , Hammad Sherin F. , El‐Malla Samah F. 
Published: July 2022

AbstractA fast, uncomplicated, sensitive and fully validated high‐performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) method has been developed for estimating l‐amino acids in the plasma of schizophrenic patients. The gradient‐elution chromatographic method was implemented with the Luna® PFP column (50 × 2.0 mm, 5 μm), and a mobile phase of 0.1% formic acid in water and methanol was used. The intra‐ and interday variability of the l‐amino acids was <13.11%, their accuracy ranged from 85.14 to 116.75% at the quality control levels and the lower limit of quantification ranged from 2.5 to 15 nm. The extraction efficiency (apparent recovery) of amino acids from healthy plasma was employed by spiking the plasma with standard amino acids at the quality control levels. Their percentage recoveries ranged from 80.4 to 119.94%. Our method has a short run time and fast sample preparation compared with existing methods, which suffer from long preparative steps and/or time‐consuming analysis, restricted reagents and the suboptimal performance characteristics of presently available technologies. Therefore, the proposed HPLC–MS/MS method was effectively applied for monitoring the l‐amino acids in the plasma of schizophrenic patients and healthy volunteers.
Impact of comprehensive family history and genetic analysis in the multidisciplinary pancreatic tumor clinic setting
Authors: Everett Jessica N. , Sanoba Shenin A. , Jing Xiaohong , Stender Cody , Schmitter Madeleine , Baptiste Ariele , Chun Jennifer , Kawaler Emily A. , Khanna Lauren G. , Gross Seth A. , Gonda Tamas A. , Beri Nina , Oberstein Paul E. , Simeone Diane M. 
Published: July 2022

AbstractBackgroundGenetic testing is recommended for all pancreatic ductal adenocarcinoma (PDAC) patients. Prior research demonstrates that multidisciplinary pancreatic cancer clinics (MDPCs) improve treatment‐ and survival‐related outcomes for PDAC patients. However, limited information exists regarding the utility of integrated genetics in the MDPC setting. We hypothesized that incorporating genetics in an MDPC serving both PDAC patients and high‐risk individuals (HRI) could: (1) improve compliance with guideline‐based genetic testing for PDAC patients, and (2) optimize HRI identification and PDAC surveillance participation to improve early detection and survival.MethodsDemographics, genetic testing results, and pedigrees were reviewed for PDAC patients and HRI at one institution over 45 months. Genetic testing analyzed 16 PDAC‐associated genes at minimum.ResultsOverall, 969 MDPC subjects were evaluated during the study period; another 56 PDAC patients were seen outside the MDPC. Among 425 MDPC PDAC patients, 333 (78.4%) completed genetic testing; 29 (8.7%) carried a PDAC‐related pathogenic germline variant (PGV). Additionally, 32 (9.6%) met familial pancreatic cancer (FPC) criteria. These PDAC patients had 191 relatives eligible for surveillance or genetic testing. Only 2/56 (3.6%) non‐MDPC PDAC patients completed genetic testing (p < 0.01). Among 544 HRI, 253 (46.5%) had a known PGV or a designation of FPC, and were eligible for surveillance at baseline; of the remainder, 15/291 (5.2%) were eligible following genetic testing and PGV identification.ConclusionIntegrating genetics into the multidisciplinary setting significantly improved genetic testing compliance by reducing logistical barriers for PDAC patients, and clarified cancer risks for their relatives while conserving clinical resources. Overall, we identified 206 individuals newly eligible for surveillance or genetic testing (191 relatives of MDPC PDAC patients, and 15 HRI from this cohort), enabling continuity of care for PDAC patients and at‐risk relatives in one clinic.
Synchroner Startschuss in Europa und Asien
Authors: Oestreich Volker 
Published: July 2022

AbstractMit der Eröffnung der Customer Solutions Center in Brühl und Singapur schafft HIMA völlig neue Möglichkeiten, um Safety‐ und Security‐Lösungen zu erleben, zu testen und gemeinsam mit Anwendern weiterzuentwickeln. Durch die Bündelung der Expertise können Anwender‐Fragestellungen zielgerichtet beleuchtet und validiert werden.
Integraler Ex‐Schutz für die komplette LNG‐Versorgungskette
Authors: Emde Ingo 
Published: July 2022

AbstractIm Zuge der Energiewende kann verflüssigtes Erdgas (LNG) als übergangslösung einen wichtigen Beitrag für die Versorgungssicherheit leisten. Da das geförderte und verflüssigte Erdgas hochentzündlich ist, muss der Explosionsschutz über die gesamte Wertschöpfungskette gewährleistet sein.
Prozessoptimierung durch Online‐Analysen
Authors: Mahler Harald , Reisinger Thorsten 
Published: July 2022

AbstractDie Prozessanalytik (PAT) spielt zusammen mit einer ausgeklügelten Systemintegration eine wichtige Rolle für den effizienten Betrieb chemischer Produktionsanlagen. Ein praktisches Beispiel einer Destillation liefert Einblicke in die technische Umsetzung und den ROI.
Cloudbasiertes Fluidmanagement
Authors: Sharpe Markus 
Published: July 2022

AbstractCloudbasierte, smarte Gesamtlösungen ermöglichen eine transparente, digitale Kommunikation. Mit einer webbasierten Plattform bietet Prominent eine sichere und ortsunabhängige überwachung von Pumpenzuständen und Prozessdaten in der Cloud. Dadurch können Betreiber die Wartung effizienter gestalten und damit die Anlagenverfügbarkeit steigern.
Mehr Sicherheit rund um SIL und PL
Authors: Garbsch Matthias 
Published: July 2022

AbstractFür Anwender ist es oft eine komplexe Herausforderung, sich im “Dschungel der Normen” für Anlagensicherheit und SIL zurechtzufinden. JUMO bündelt deshalb die Produkt‐ und Lösungskompetenz zu diesen Themen in der Marke JSP (JUMO Safety Performance) und will damit Engineeringkosten sparen.
Optimale Prozesshygiene durch Chlordioxid
Authors: Zimmermann Janina 
Published: July 2022

AbstractEine gute Wasserqualität ist unerlässlich für moderne Produktionsprozesse in einer Vielzahl von Branchen. Das Clorious2‐Desinfektionssystem ermöglicht, für diesen Zweck die bewährten Vorteile von Chlordioxid zu nutzen. Das schafft nicht nur dauerhaft biofilmfreie und hygienische Bedingungen, sondern eröffnet auch neue Optimierungs‐ und Einsparmöglichkeiten in der Desinfektion.
Erdbebensichere Chemieanlagen
Authors: Wirth Stefan 
Published: July 2022

AbstractDurch die Einführung des neuen Erdbeben Eurocodes DIN EN 1998‐1/NA müssen die Gefahren in Chemieanlagen und deren Auswirkungen auf die Tragstrukturen, Einbauten und Versorgungsbauwerke neu bewertet werden.
Design, Synthesis and Biological Evaluation of Potent and Selective S1PR1 Agonists for the Treatment of Ulcerative Colitis
Authors: He Huan , Xie Mengting , Zhang Mengting , Zhang Haiqin , Zhu Huan , Fang Yuxian , Shen Zihao , Wang Rui , Zhao Zhenjiang , Zhu Lili , Qian Xuhong , Li Honglin 
Published: July 2022

Comprehensive SummaryThe binding of Sphingosine‐1‐phosphate (S1P) with the S1PR1‐5 plays a fundamental physiological role in a number of processes including vascular development and stabilization, lymphocyte migration and distribution. S1P‐S1PR1 signal axis established roles in immune cell trafficking thus playing a therapeutic role in multiple sclerosis and inflammatory bowel disease. In this study, a series of oxadiazole derivatives were designed and synthesized as S1PR1 agonists based on rational drug design. Among them, compound 9i was identified as a potent and selective S1PR1 agonist with activities on β‐arrestin recruitment (EC50 = 0.36 nmol/L) and receptor internalization (EC50 = 8.09 nmol/L). Meanwhile, compound 9i displayed an oral bioavailability up to 93.6%. Based on its excellent activity to S1PR1 and pharmacokinetic properties, compound 9i effectively alleviated dextran sulfate sodium (DSS)‐induced ulcerative colitis in mice at a dose of 0.1 mg/kg.
Axolotl: A resourceful vertebrate model for regeneration and beyond
Authors: Bölük Aydın , Yavuz Mervenur , Demircan Turan 
Published: July 2022

AbstractThe regenerative capacity varies significantly among the animal kingdom. Successful regeneration program in some animals results in the functional restoration of tissues and lost structures. Among the highly regenerative animals, axolotl provides multiple experimental advantages with its many extraordinary characteristics. It has been positioned as a regeneration model organism due to its exceptional renewal capacity, including the internal organs, central nervous system, and appendages, in a scar‐free manner. In addition to this unique regeneration ability, the observed low cancer incidence, its resistance to carcinogens, and the reversing effect of its cell extract on neoplasms strongly suggest its usability in cancer research. Axolotl's longevity and efficient utilization of several anti‐aging mechanisms underline its potential to be employed in aging studies.
Ecological drivers of avian diversity in a subtropical landscape: Effects of habitat diversity, primary productivity and anthropogenic disturbance
Authors: Shuai Ling‐Ying , Xiao Shu‐Ping , Xie Yan‐Ping , Chen Xing‐Min , Song Xiang‐Rong , Fan Tian‐Qiao , Xie Yun‐Hua , Liu Wei 
Published: July 2022

AbstractUnderstanding the roles of ecological drivers in shaping biodiversity is fundamental for conservation practice. In this study, we explored the effects of elevation, conservation status, primary productivity, habitat diversity and anthropogenic disturbance (represented by human population density and birding history) on taxonomic, phylogenetic and functional avian diversity in a subtropical landscape in southeastern China. We conducted bird surveys using 1‐km transects across a total of 30 sites, of which 10 sites were located within a natural reserve. Metrics of functional diversity were calculated based on six functional traits (body mass, clutch size, dispersal ratio, sociality, diet and foraging stratum). We built simultaneous autoregression models to assess the association between the ecological factors and diversity of the local avian communities. Local avian diversity generally increased with increasing habitat diversity, human population density and primary productivity. We also detected phylogenetic and functional clustering in these communities, suggesting that the avian assemblages were structured mainly by environmental filtering, rather than interspecific competition. Compared with sites outside the natural reserve, sites within the natural reserve had relatively lower avian diversity but a higher level of phylogenetic heterogeneity.
Asymmetric generalizability of multimodal brain‐behavior associations across age‐groups
Authors: Yu Junhong , Fischer Nastassja L. 
Published: July 2022

AbstractMachine learning methods have increasingly been used to map out brain‐behavior associations (BBA), and to predict out‐of‐scanner behavior of unseen subjects. Given the brain changes that occur in the context of aging, the accuracy of these predictions is likely to depend on how similar the training and testing data sets are in terms of age. To this end, we examined how well BBAs derived from an age‐group generalize to other age‐groups. We partitioned the CAM‐CAN data set (N = 550) into the young, middle, and old age‐groups, then used the young and old age‐groups to construct prediction models for 11 behavioral outcomes using multimodal neuroimaging features (i.e., structural and resting‐state functional connectivity, and gray matter volume/cortical thickness). These models were then applied to all three age‐groups to predict their behavioral scores. When the young‐derived models were used, a graded pattern of age‐generalization was generally observed across most behavioral outcomes—predictions are the most accurate in the young subjects in the testing data set, followed by the middle and then old‐aged subjects. Conversely, when the old‐derived models were used, the disparity in the predictive accuracy across age‐groups was mostly negligible. These findings hold across different imaging modalities. These results suggest the asymmetric age‐generalization of BBAs—old‐derived BBAs generalized well to all age‐groups, however young‐derived BBAs generalized poorly beyond their own age‐group.
Mirror neuron brain regions contribute to identifying actions, but not intentions
Authors: Thompson Emma L. , Bird Geoffrey , Catmur Caroline 
Published: July 2022

AbstractPrevious studies have struggled to determine the relationship between mirror neuron brain regions and two distinct “action understanding” processes: identifying actions and identifying the intentions underlying those actions. This may be because the identification of intentions from others' actions requires an initial action identification process. Disruptive transcranial magnetic stimulation was administered to left inferior frontal gyrus (lIFG) during a novel cognitive task to determine which of these “action understanding” processes is subserved by mirror neuron brain regions. Participants identified either the actions performed by observed hand actions or the intentions underlying those actions. The extent to which intention identification was disrupted by lIFG (vs. control site) stimulation was dependent on the level of disruption to action identification. We subsequently performed functional magnetic resonance imaging during the same task. During action identification, responses were widespread within mirror neuron areas including lIFG and inferior parietal lobule. However, no independent responses were found in mirror neuron brain regions during intention identification. Instead, responses occurred in brain regions associated with two distinct mentalizing localizer tasks. This supports an account in which mirror neuron brain regions are involved in an initial action identification process, but the subsequent identification of intentions requires additional processing in mentalizing brain regions.
Metastatic neuroendocrine carcinoma of right adrenal gland successfully treated with laparoscopic adrenalectomy after multimodal therapy
Authors: Yamagata Yusuke , Abe Takashige , Iwahara Naoya , Takada Kohichi , Hida Yasuhiro , Takakuwa Emi , Kikuchi Hiroshi , Matsumoto Ryuji , Osawa Takahiro , Shinohara Nobuo 
Published: July 2022

AbstractIntroductionWe report a case of laparoscopic adrenalectomy in a salvage setting after multiple chemotherapies for neuroendocrine carcinoma.Case presentationA 49‐year‐old man was diagnosed with unknown primary carcinoma with single brain metastasis, and right supraclavicular and mediastinal lymph node metastases. After stereotactic radiotherapy of the brain metastasis and systemic chemotherapy, lymphadanectomy was performed. The pathologic diagnosis was neuroendocrine carcinoma. At 11 months after surgery, computed tomography revealed right adrenal metastasis. Local radiotherapy initially resulted in complete remission. However, adrenal recurrence was noted 10 months later. Laparoscopic adrenalectomy was performed with curative intent. The patient is currently alive without recurrence at 20 months after the operation.ConclusionAdrenalectomy can become a treatment option if other metastases are well‐controlled with systemic therapy. Surgical elimination of oligometastases can offer long‐term disease control in selected patients as part of a multimodal approach.
A pilot study investigating the role of 18F‐FDG‐PET in the early identification of chemoradiotherapy response in anal cancer
Authors: Smith Drew , Joon Daryl Lim , Knight Kellie , Sim Jenny , Schneider Michal , Lau Eddie , Foroudi Farshad , Khoo Vincent 
Published: July 2022

AbstractIntroductionAnal cancer (AC) is 18F‐FDG‐PET avid and has been used to evaluate treatment response several months after chemoradiotherapy. This pilot study aimed to assess the utility of semi‐automated contouring methods and quantitative measures of treatment response using 18F‐FDG‐PET imaging at the early time point of 1‐month post‐chemoradiotherapy.MethodsEleven patients with AC referred for chemoradiotherapy were prospectively enrolled into this study, with 10 meeting eligibility requirements. 18F‐FDG‐PET imaging was obtained pre‐chemoradiotherapy (TP1), and then 1‐month (TP2), 3–6 months (TP3) and 9–12 months (TP4) post‐chemoradiotherapy. Manual and semi‐automated (Threshold) contouring methods were used to define the primary tumour on all 18F‐FDG‐PET images. Resultant contours from each method were interrogated using quantitative measures, including volume, response index (RI), total lesion glycolysis (TLG), SUVmax, SUVmedian and SUVmean. Response was assessed quantitatively as reductions in these measures and also qualitatively against established criteria.ResultsNine patients were qualitatively classified as complete metabolic responders at TP2 and all 10 at TP3. All quantitative measures demonstrated significant (P < 0.05) reductions at TP2 for both Manual and Threshold methods. All reduced further at TP3 and again at TP4 for Threshold methods. TLG showed the highest reduction at all post‐chemoradiotherapy time points and classified the most responders for each method at each time point. All patients are recurrence‐free at minimum 4‐year follow‐up.ConclusionBased on our small sample size, semi‐automated methods of disease definition using 18F‐FDG‐PET imaging are feasible and appear to facilitate quantitative response classification of AC as early as 1‐month post‐chemoradiotherapy. Early identification of treatment response may potentially improve disease management.
Distinct immune responses in the early phase to natural SARS‐CoV‐2 infection or vaccination
Authors: Peng Pai , Deng Haijun , Li Zhihong , Chen Yao , Fang Liang , Hu Jie , Wu Kang , Xue Jianjiang , Wang Deqiang , Liu Beizhong , Long Quanxin , Chen Juan , Wang Kai , Tang Ni , Huang Ai‐long 
Published: July 2022

AbstractImmune responses elicited by viral infection or vaccination play key roles in the viral elimination and the prevention of reinfection, as well as the protection of healthy persons. As one of the most widely used Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines, there have been increasing concerns about the necessity of additional doses of inactivated vaccines, due to the waning immune response several months after vaccination. To further optimize inactivated SARS‐CoV‐2 vaccines, we compared immune responses to SARS‐CoV‐2 elicited by natural infection and immunization with inactivated vaccines in the early phase. We observed the lower antibody levels against SARS‐CoV‐2 spike (S) and nucleocapsid (N) proteins in the early phase of postvaccination with a slow increase, compared to the acute phase of SARS‐CoV‐2 natural infection. Specifically, IgA antibodies have the most significant differences. Moreover, we further analyzed cytokine expression between these two groups. A wide variety of cytokines presented high expression in the infected individuals, while a few cytokines were elicited by inactivated vaccines. The differences in antibody responses and cytokine levels between natural SARS‐CoV‐2 infection and vaccination with the inactivated vaccines may provide implications for the optimization of inactivated SARS‐CoV‐2 vaccines and the additional application of serological tests.
Effect of the Trans‐Volcanic Axis on meridional propagation of summer precipitation in western Mexico
Authors: Brito‐Castillo Luis , Farfán Luis M. , Antemate‐Velasco Geimond Jarumi 
Published: July 2022

AbstractThe Trans‐Volcanic Axis (TVA)—comprising ridges and terrain elevations above 1,900 m—strongly affects meridional propagation of summer precipitation in western Mexico. This barrier modifies atmospheric moisture content and changes the annual precipitation cycle configuration, which distinguishes it from the precipitation cycle on both sides of the TVA. Using upper‐air observations and rainfall records, this study demonstrates that the TVA is the region where the North American monsoon (NAM) and the mid‐summer drought (MSD) influence intersections regarding precipitation. This region affects both northward extent of double precipitation maxima with the MSD and the southward extent of the NAM single precipitation peak. This study proposes that the forcing mechanism that controls the annual precipitation cycle in the TVA region relies on latent heat loss via ground cooling by reducing air temperature below dewpoint temperature in the 700–500 hPa layer, consistent with local terrain elevations. The orographic effect increases specific humidity in the atmospheric column—sufficiently large to enhance local precipitation accumulation—resulting in a mid‐summer drought intensity decline but not enough to yield a single peak in precipitation. Consequently, the TVA becomes an uncategorized region that does not display the NAM nor the characteristic features of the MSD.
Impact of Socioeconomic Demographics and Race on Laryngotracheal Stenosis Etiology and Outcomes
Authors: Plocienniczak Michal , Sambhu Krishna Madhav , Noordzij J. Pieter , Tracy Lauren 
Published: July 2022

ObjectiveCertain sociodemographic variables are known to result in health care disparities. This study investigates potential differences in outcomes for patients with laryngotracheal stenosis (LTS) based on racial backgrounds and socioeconomic variables including insurance status and English language‐Proficiency.MethodsPatients with LTS from 2016 to 2021were identified by relevant ICD codes. Variables including race, age, gender, language preference and insurance status were collected from medical records. Risk factors for LTS including COPD, smoking history, diabetes, GERD, and BMI were obtained. Etiology of LTS was categorized as autoimmune, traumatic, iatrogenic, or idiopathic. Need for temporary tracheostomy and tracheostomy dependence were determined at last follow‐up visit.Results129 patients were included for review. 70% of Black patients had iatrogenic LTS, whereas 65% of the White patient cohort had autoimmune or idiopathic LTS. Black patients were more strongly associated with temporary tracheostomy and tracheostomy dependence compared to White patients. Public health insurance and co‐morbid GERD were associated with tracheostomy dependence for White patients only.ConclusionThis study identified a disproportionate representation of Black patients in the iatrogenic etiology of LTS. Although controlling for risk factors of LTS, this cohort had an increased need for temporary tracheostomy and tracheostomy dependence compared to White and Latinx cohorts. This finding merits further study.Level of Evidence3 Laryngoscope, 133:908–913, 2023