bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Pancreatic Lesions by Computed Tomography Scan: A Study Protocol
Authors: Gulve Sharvari Shashikant , Parihar Pratap Singh , Dhande Rajasbala 
Published: February 2022

Background: The pancreas is a hidden organ and was one of the last organs in the abdomen to be analyzed by anatomists, physiologists, physicians, and surgeons. Pancreatic lesions may range from mild inflammation to malignancy. Ultrasound was the first cross-sectional technique that permitted direct imaging of the pancreas. It permitted precise visualization of pancreatic parenchyma, pancreatic ducts and bile ducts. This study aims to evaluate various pancreatic lesions using CT scan and assess their correlation with histopathological findings.
Methodology: This will be an observational study conducted at department of radiodiagnosis, AVBRH, Wardha. Total 180 patients with pancreatic disease confirmed by clinical, laboratory and ultrasonography will be enrolled in the study. All 180 patients will undergo plain and contrast enhanced CT scan. Results will be judged, based on the observations and finding on CT scan, biochemical and histopathological reports whenever possible. Modified CT Severity Index / Mortele Modified CTSI Scoring will be used to assess severity of acute pancreatitis and acute exacerbation of chronic pancreatitis.
Results: We expect to explore on the common etiological factors, gender and age distribution of various pancreatic diseases. Correlation between grade of acute pancreatitis according to modified CT severity index and clinical outcome of patients. In case of chronic will be evaluated.
Conclusion: CECT is excellent diagnostic modality to stage severity of inflammatory process and staging of neoplastic lesions. Severity grading in acute exacerbation of chronic pancreatitis will be meticulously observed and significant conclusive findings will be found. CECT imaging with its postprocessing techniques represents the image of choice for diagnosis and predicting pancreatic masses.
Evaluation and Comparison of Biomechanical Properties of a New “PRP Loop” with that of Opus Loop and L-Loop - a FEM Study
Authors: Kumari Smita , Niranjane Priyanka , Kamble Ranjit 
Published: February 2022

Introduction: Closure of space is a salient factor in orthodontic treatment. Friction and frictionless mechanics are the methods of extraction space closure. Retraction loops eg. T loop, Opus loop, K Sir loop, L loop etc used force system as frictionless mechanics. An attempt has been made to blend the design of both Opus and L loops to form a new loop called “PRP loop” so that the beneficial properties of L loop and Opus loop can be integrated into the new loop. This study is therefore undertaken to evaluate the biomechanical effect of PRP loop and compare it to the “L loop and Opus loop”.
Objectives: To evaluate and compare the moment to force ratio of PRP loop, Opus loop and L loop fabricated in “0.019×0.025 inch” and “0.017×0.025 inch” “TMA wire with and” without any “ preactivation bends” and to “compare the moment to force ratio” of PRP loop with “Opus loop”, and L loop fabricated in 0.019×0.025 wire with those fabricated in 0.017×0.025 wire.
Methodology: PRP loop, “L loop and Opus loop” will be fabricated in “0.019×0.025 and 0.017×0.025 inch TMA wire” without pre activation bends. Using the dHAL software moment to force ratio will be calculated for PRP loop of “0.019×0.025 inch” and “0.017×0.025 inch” “TMA wire with and” without different degrees of alpha pre-activation bends.
Ansys 16.0 finite element analysis software will be used to form the loops of three dimensional model after that the forces and moments in all three dimensions will be studied.
Expected Result: The moment to force of PRP loop will be evaluated to so that optimum force level can be determined to prove its clinical efficiency.
Conclusion: No such study has been done on PRP loop. Hence, a study is planned to evaluate and compare the ”biomechanical properties of PRP loop with that of Opus loop and L loop”
A Comparative Study on Changes in Postoperative Care of Patients Undergoing Emergency Surgeries in a Tertiary Care Centre between COVID and Non-COVID Patients
Authors: Kamaraja Kaviya , Rajesh S. 
Published: February 2022

Aim: To observe and analyze changes in postoperative management between COVID and non- COVID patients who undergo emergency surgeries in a tertiary care hospital in Kanchipuram, Chennai.
Objective: To analyze the postoperative care and compare the hospital stay, incision, drugs used and other system complications between COVID and non-Covid patients.
Materials and Methods: A retrospective observational study of 40 subjects who came to the general surgery department for emergency procedures were studied. The study duration was 4 months. The exclusion criteria were obstetric and orthopaedic emergencies and patients between the age of 16 years and above 60 years. All the emergencies in the general surgery department were done under anaesthesia.
Results: The postoperative outcome between the subjects who were COVID positive and negative was quite similar but an increased postoperative stay due to delay in wound healing was observed. This was not found to be directly caused by the COVID infection but mostly due to the drugs used in its management and the patient’s comorbidities and lifestyle choices.
The Effects of Lifestyle Modofications on Sperm DNA Fragmentation Index
Authors: Chauhan Vaishnavi Virendra Singh , More Akash , Gajbe Ujwal , Shrivastava Deepti 
Published: February 2022

Background: Most of the men go through infertility due to DNA defects in sperm. DNA defects in sperm can be measured by sperm DNA fragmentation test. Sperm DNA splitting have been correlated with sperm viability and its major impact on male infertility. Many studies have shown that men with disturbed lifestyle habits such as smoking ,alcoholic consumption ,poor diet have very poor DNA quality compared to the men with proper habits like good diet , exercise and a well maintained routine. There has been many tests to measure the DNA breakage after conducting proper semen examination and infertility duration. This can be treated with proper medications and regular exercise.
Objectives: 1. To predict the reason for male infertility by evaluating routine semen parameters.

To study the effects of daily lifestyle habits associated with SDF in patients who are not fertile.
To investigate the amount of sperm DNA splitting in men who are not fertile. 4.To investigate the association between DFI and semen quality, between DFI and IVF, between DFI and IUI. 5.To estimate the outcomes of sperm DNA fragmentation index and allow the patients to seek post infertility treatments.

Methods: This non-invasive methodology includes recording of treatment history and the indications of infertility. Proper counselling for the patients were done. A proforma were filled along with their consent showing the accuracy of smoking, alcohol consumption, stress levels and other mentioned factors and hence calculating the sperm breakage levels.
A Study on Short Segment Fixation for Thoracolumbar Fractures
Authors: Khan Sohael M. , Dasari Venkatesh , Samal Nitin , Bukhari Rameez , Gupta Suvarn , Waghmare Antariksh 
Published: February 2022

Background: Spine injury is being one of the commonest injuries which pose challenges to the patients and treating clinicians as well. Despite so much research and recent advances, there has not been unanimous consensus regarding the management of spinal injuries. However, the treatment aim of every injury to the spine is to restore of max possible function in patients. This study was conducted to assess the outcome of short segment fixation in fractures of the thoracolumbar spine.
Methods and Materials: This is a prospective cohort study done at our Tertiary Center during the period from April 2018 To September 2020. Patients with thoracolumbar spine injuries were, included in the study. Study on short-segment pedicle screw fixation and inter- transverse fusion for single-level acute thoracolumbar fracture.
Results: Mean age of the sample size was 40.58 years with male preponderance. The FRANKEL SCALE was used to grade the pre-op neurology; 17.2% were graded as E, 24.1% as D, 31% as C, 13.8 % as B, and 13.8% A. ASIA motor and sensory score preoperative and postoperative at one year follow up was compared was found to be significant (p<0.05). Preoperative VAS and Functional independent measures also showed significant improvement.
Conclusion: Surgical stabilization and decompression are essential strategies for further neuroprotection and recovery after a spine injury. Short segment fixation can be an option for thoracolumbar fracture. However, an unstable fracture may require extended fixation.
Awareness about Early Menarche and Its Associated Problems among Female Medical Students of a Tertiary Care Hospital in Chennai, Tamil Nadu
Authors: Siva V. K. , Archana . 
Published: February 2022

Background: In many developing countries, the age of menarche is declining due to various factors. Early pubertal development or early menarche among girls could be associated with higher risks of poor health, so it is important to bring awareness and gain knowledge about early menarche and it's associated problems.
Aim: To assess the awareness and knowledge about early menarche and its associated problems among female medical students.
Settings and Design: Cross-sectional study was done among the 1st year, 2nd year and 3rd year girls studying in a medical college in Chennai.
Methods: This study was conducted among 232 participants. A convenient sampling method was used. A pretested semi-stricter questionnaire was used to assess the knowledge and awareness about early menarche and its associated problems.
Statistical Analysis Used: Data was entered in an excel spreadsheet and analysed using SPSS software version 16, statistical analysis was done using the Chi-square test.
Results: Out of 232 participants 33.7% had good knowledge about early menarche and its associated problems. There was a significant association between the year of study and the level of knowledge of the participants. 42.35% were aware that “early menarche can lead to breast cancer and ischemic heart disease”.
Conclusion: Thus, this study helps us to bring more awareness about early menarche and its associated problems and to prevent it by gaining knowledge about the factors resulting in early menarche.
Role of Tocilizumab in Fighting COVID 19
Authors: Pani Anuttam Arijit , Joshi Abhishek 
Published: February 2022

Background: Tocilizumab is the repurposed drug used in the severely ill COVID-19 patients. A lot of traction has gain over the drug but more studies are awaited to ensure the efficacy of the drug with proper backing from empirical data. Tocilizumab, a drug which is used in treatment of rheumatoid arthritis suddenly came into limelight when it got listed as drugs used for the treatment of COVID-19 patients. As earlier discussed, many existing drugs which were already in use for treating other ailments were being tested if they are suitable to treat COVID-19 disease. Tocilizumab have the anti-inflammatory properties which were in particular were useful in COVID-19 which creates an inflammation all across the organs.
Summary: COVID-19 is the novel disease outbreak later progressed into deadly pandemic has presented the huge challenge to contain it clinically as no drug was available prior the outbreak of the disease. Vast amount of drugs can be used to at least suppress the viral spread which was found to be true. Although it was not hundred percent foolproof but it was an emergency situation and various drugs were used according to local ground conditions and patients response to the drug along with age and severity of the illness. Tocilizumab was one such drug which was repurposed for the treatment of COVID-19 patients. Many drugs such as Hydroxycholoroquine (HCQ), Tocilizumab were repurposed from their existing use. Tocilizumab is currently used in the treatment of rheumatoid arthritis. Various studies have shown the efficacy of the drug among the severely ill COVID-19 patients which ranges up to 66 percent. In certain cases worsening of the existing medical condition has been observed.
Conclusion: Vaccine nationalism must be set aside and low and middle income countries where most of the population of the world resides, should be vaccinated as even one case can culminate into another disaster as was seen during highly contagious COVID-19. More empirical data is needed from across the globe to ensure the assessment of the efficacy of the drug. Also certain cases of shortage of the said drug for non-COVID-19 purpose also looked into seriously has it can create a parallel disaster.
Astronaut Era: Does Your Child Patient Accept Your New Look and Practicality of Using Behaviour Modification Techniques in COVID Times?
Authors: Farooq Sana , Lone Nazia , Sidiq Mohsin 
Published: February 2022

Background: The coronavirus (COVID-19) has challenged health care professionals and dental professionals play a pivotal role in preventing transmission of COVID 19.
Aim: This study aimed to evaluate the knowledge, attitude, skills and preparedness of Pediatric dentist in managing a case in their dental operatory in COVID times.
Materials and Methodology: A cross-sectional survey was carried out in June 2020 on 52 dental specialists who were contacts of invigilator and had done post graduation in Pedodontics and Preventine Dentistry at Delhi NCR or were practicing Pedodontist in Jammu & Kashmir. A 10 question based questionnaire was developed to assess their knowledge, awareness and skills . Data were subjected to appropriate statistical measures and analyzed.
Result: Amongst 52 Pedodontist who took part in survey 23.08% were pedodontist with experience of three and more years where as 53.85% were still undergoing postgraduation in the speciality of Pedodontics and Preventive Dentistry.100% of pediatric dentist thought its pre requisite to screen the temperature of all the children and attendants using infrared thermometer before taking proper history and thought of conducting examination only after a preprocedural mouthrinse of 1% hydrogen peroxide.
Conclusion: An aware and knowledgeable pedodontist following the latest guidelines can handle children well in situation where behaviour modification techniques are hampered due to use of PPE(Personnal Protective Equipment). It is important to educate all the patients about coughing etiquettes and the dental professionals about modification required in a dental clinic set-up for managing cases requiring urgent dental care.
Study of Platelet Indices in Patients with Metabolic Syndromes: A Study Protocol
Authors: Shah Divit P. , Kumar Sunil , Acharya Sourya , Bawankule Shilpa 
Published: February 2022

Background: Metabolic syndrome is a syndrome of unified metabolic disorder which includes abdominal obesity (AO), hypertension, hypertriglyceridemia (HTG), hyperglycemia and decreased high-density lipoprotein (HDL). Metabolic syndrome subjects are exposed to greater chances to have insulin resistance, visceral fat accumulation, atherogenic changes to the vessels, abnormal lipid levels and abnormal functioning of endothelium. Platelets play a key role in hemostasis. The mean platelet volume (MPV) and platelet’s proportion are indicators of platelet function. This study aims to find the correlation between various platelet indices in patients with Metabolic syndromes.
Methods: This prospective study is planned to be conducted in AVBRH, Wardha. Patients anthropometric parameters like height, weight, blood pressure, waist circumference, hip circumference and biochemical parameters such as fasting blood glucose, serum triglycerides, serum HDL, and mean platelet volumes will be assessed. Total 130 subjects will be assessed and data will be analyzed to estimate a correlation between platelet indices and metabolic syndromes.
Expected Results: A significant correlation is expected between various platelet indices in patients of different metabolic syndromes.
Preparation of Mouth Wash Using Musa sapientum Mediated Silver Nanoparticles and Its Antimicrobial Activity
Authors: Roshan A. , Priyadharshini R. , Rajeshkumar S. , Sinduja Palati 
Published: February 2022

Introduction: Musa sapientum are primarily grown in tropical and subtropical countries, and are commonly used around the world for their nutritional values. Peels were examined for mineral, nutritional content. The product of the mineral content is that the concentration of potassium, calcium, magnesium, iron, manganese, bromine, and rubidium are high. M. sapientum pulp showed high antimicrobial activity against 13 gram-positive and gram-negative bacteria.
Materials and Methods: The plant extract was prepared. Silver nanoparticles were taken in the form of AgNO3. The plant extract was tested for its anti-inflammatory activity by protein denaturation assay. To assess the antimicrobial activity, the prepared extract was inoculated in different culture plates containing different microorganisms. The results obtained were collected and statistically analyzed in SPSS software and graphs were obtained.
Results: Analysis of antimicrobial activity shows The zone of inhibition in Mueller Hinton agar showed C. albicans zone of inhibition in the cultured plate with the diameter of 10 mm, 12 mm and 25 mm in 25 µL, 50 µL, and 100 µL respectively. S. mutans zone of inhibition in the cultured plate with the diameter of 15 mm, 18 mm, and 22 mm at 25 µL, 50 µL, and 100 µL respectively.
Conclusion: From the results obtained and analyzed we may conclude that silver nanoparticles synthesized using Musa sapientum extract can be used as a good anti-microbial agent. Its anti-microbial activity can be enhanced by increasing the concentration. Hence furt her advancements in this study could lead to producing and marketing natural product-based antimicrobial and anti-inflammatory agents.
New Perspectives on Clopidogrel Resistance Systematic Review and Meta-analysis
Authors: Alrahbeni Tahani 
Published: February 2022

Background: Clopidogrel resistance can be defined as the failure of clopidogrel to inhibit its target of action. The prevalence of clopidogrel resistance in various studies ranges between 5%–44%. Clopidogrel resistance is a serious scary condition whereby clopidogrel drug is less or not effective for some patients than expected. Hence the present Systematic review was conducted to explore the new perspectives of Clopidogrel and to evaluate the effect of genetic cytochrome CYP2C19 (CYP2C19*2, CYP2C19*3) of the key drug metabolizing enzymes on the response to the anti-platelet effect of clopidogrel. To provide insights into the commentary summarizes the clinical evidence on the pharmacokinetic determinants of clopidogrel efficacy.
Material and Method: Systematic review is a type of literature reviews that collects and critically analyzes multiple research studies using methods that are selected before one or more research questions are formulated and then finding and analyzing studies that relate to and answer those questions in a structured methodology.
Results: Accumulated information from suggested the presence of high incidence of clopidogrel resistance. Associated with acute coronary syndrome (ACS), Acute myocardial infarction (AMI) and stroke. There was no significant difference in the incidence of resistance according to the type of studies.
Conclusion: Accumulated information from previous studies and the present systematic review suggested the presence of high incidence of clopidogrel resistance. This resistance was associated with serious complications such as acute coronary syndrome (ACS), Acute myocardial infarction (AMI) and stroke.
Determination of Spectrum of Symptoms Observed Followed by Administration of 1st and 2nd Doses of COVISHIELD™ Vaccine in Datta Meghe Institute of Medical Sciences (Deemed to be University) – A Study Protocol
Authors: Mishra Gaurav , Dhande Rajasbala , Gaidhane Abhay , Singh Rohan Kumar , Patwa Prerna , Jumade Prashil 
Published: February 2022

Background: The 2019 novel coronavirus (2019-nCoV or SARS-CoV-2) was first detected in December 2019 in Wuhan City of Hubei, Province of China with population of 11 million, after outbreak of pneumonia. Present study deals with acceptability of newly manufactured vaccines against Covid 19 disease component of social misconceptions regarding the post vaccination symptoms and/or adverse events. Main rationale of this study is to list all post vaccination symptoms observed at multiple points of time to clear misconceptions resulting in possible increase in acceptability of newer vaccines.
Aim: To determine the spectrum of symptoms observed followed by administration of 1st and 2nd doses of COVISHIELD™ vaccine in Datta Meghe Institute of Medical Sciences (deemed to be university).
Methods: This will be a Prospective analytical cohort study conducted over a period of 5 years.
Procedure: Followed by letter of informed consent, pre validated questionnaire will be circulated amongst the healthcare professionals having been administered the 1st and 2nd doses of COVISHIELD™ vaccine filled and submitted to authorized email for further study and will be evaluated for enlisting post vaccination symptoms with time of onset and duration following 1st and 2nd doses of COVISHIELD™ vaccine. Follow up will maintained at regular intervals and questionnaire will be amongst participants at 6 months, 1 year, 2 years, 3 years, 4 years and 5 years after the 2nd dose of COVISHIELD™ vaccine.
Expected Outcome: Post vaccination symptoms following 1st and 2nd doses of COVISHIELD™ vaccine with range of time of onset and duration of the same will enhance status of the COVISHIELD™ vaccine awareness, social acceptability and willingness.
Conclusion: All conclusions will be drawn after proper statistical analysis.
Assessment of Awareness about Occupational Safety among Laboratory Staff in Healthcare Settings: A Study Protocol
Authors: Chiwande Ekta Sandip , Shinde Vitthal , Gudhe Vandana 
Published: February 2022

Background: Occupational health and safety is very important factor in the health care industries. The health care professionals are very important part of the hospital that provides number of services to the population. To provide better services to the community the health care professionals have to take care of themselves very well at their workplace. In this health care industries the health care professionals who are working in the diagnostic laboratories are the major factors. Health and safety of the health care professionals is very important aspect to reduce the risk factors. Medical diagnostic laboratories pose a lot of risks to the healthcare staff and awareness generation among the health care professionals to mitigate the hazards is important. This study aims to assess the awareness about occupational health safety measures among the laboratory staff and instil awareness about safety measures.
Methodology: This will be a cross-sectional study. Investigator will administer a structured questionnaire among selected study participants from Central laboratory at AVBRH . The data will be analysed with appropriate analytical software and statistical tests.
Expected Result: The expected outcome could reflect that the health care professionals are well aware of occupational hazards and health and safety issues at their work place.
Conclusion: The level of awareness about the health safety at the workplace among health care workers working in the central laboratory is the vital parameter to ensure occupational safety and security.