bluuebunny/crossref_metadata_2025_split huggingface dataset:
The core bacterial microbiome of banana (Musa spp.)
Authors: Birt Henry W. G. , Pattison Anthony B. , Skarshewski Adam , Daniells Jeff , Raghavendra Anil , Dennis Paul G. 
Published: September 2022

Abstract
Background
Bananas (Musa spp.) are a globally significant crop and are severely afflicted by diseases for which there are no effective chemical controls. Banana microbiomes may provide novel solutions to these constraints but are difficult to manage due to their high diversity and variability between locations. Hence ‘common core’ taxa, which are a subset of the microbiome that frequent all, or most, individuals of a host species, represent logical targets for the development of microbiome management approaches. Here, we first performed a pot experiment to characterise the effects of two factors that are likely to differ between farms (viz. edaphic conditions and host genotype) on bacterial diversity in bulk soil and seven plant compartments. From this experiment, we created shortlisted core ‘candidates’ that were then refined using a survey of 52 field-grown Musa spp. We confirmed the importance of the core through network analysis and by comparing the sequences of our core taxa with those reported in 22 previous studies.

Results
Diversity was found to differ between plant compartments and soils, but not genotypes. Therefore, we identified populations that were frequent across most plants irrespective of the soil in which they were grown. This led to the selection of 36 ‘common core’ bacteria, that represented 65–95% of the dominant taxa in field-grown plants and were identified as highly interconnected ‘hubs’ using network analysis – a characteristic shown to be indicative of microbes that influence host fitness in studies of other plants. Lastly, we demonstrated that the core taxa are closely related to banana-associated bacteria observed on five other continents.

Conclusions
Our study provides a robust list of common core bacterial taxa for Musa spp. Further research may now focus on how changes in the frequencies and activities of these most persistent taxa influence host fitness. Notably, for several of our core taxa, highly similar populations have already been isolated in previous studies and may be amenable to such experimentation. This contribution should help to accelerate the development of effective Musa spp. microbiome management practices.
Alpha radionuclide-chelated radioimmunotherapy promoters enable local radiotherapy/chemodynamic therapy to discourage cancer progression
Authors: Zhang Jiajia , Li Feize , Yin Yuzhen , Liu Ning , Zhu Mengqin , Zhang Han , Liu Weihao , Yang Mengdie , Qin Shanshan , Fan Xin , Yang Yuanyou , Zhang Kun , Yu Fei 
Published: September 2022

Abstract

Background
Astatine-211 is an α-emitter with high-energy α-ray and high cytotoxicity for cancer cells. However, the targeted alpha therapy (TAT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis and relapse. Combined immune checkpoint blockade (ICB) with chemodynamic therapy (CDT) could boost antitumor immunity, which may magnify the immune responses of TAT. This study aims to discourage tumor metastasis and relapse by tri-model TAT-CDT-ICB strategy.

Methods

We successfully designed Mn-based radioimmunotherapy promoters (
211
At-ATE-MnO
2
-BSA), which are consisting of
211
At, MnO
2
and bovine serum albumin (BSA). The efficacy of
211
At-ATE-MnO
2
-BSA was studied as monotherapy or in combination with anti-PD-L1 in both metastatic and relapse models. The immune effects of radioimmunotherapy promoters on cytotoxic T lymphocytes and dendritic cells (DCs) were analyzed by flow cytometry. Enzyme-linked immunosorbent assay and immunofluorescence were used to explore the underlying mechanism.

Results

Such radioimmunotherapy promoters could not only enhance the therapeutic outcomes of TAT and CDT, but also induce robust anti-cancer immune activity by activating dendritic cells. More intriguingly,
211
At-ATE-MnO
2
-BSA could effectively suppress the growths of primary tumors and distant tumors when combined with immune checkpoint inhibitors.

Conclusions
The tri-model TAT-CDT-ICB strategy provides a long-term immunological memory, which can protect against tumor rechallenge after eliminating original tumors. Therefore, this work presents a novel approach for TAT-CDT-ICB tri-modal cancer therapy with repressed metastasis and relapse in clinics.
Time series aggregation for energy system design: review and extension of modelling seasonal storages
Authors: Blanke Tobias , Schmidt Katharina S. , Göttsche Joachim , Döring Bernd , Frisch Jérôme , van Treeck Christoph 
Published: September 2022

AbstractUsing optimization to design a renewable energy system has become a computationally demanding task as the high temporal fluctuations of demand and supply arise within the considered time series. The aggregation of typical operation periods has become a popular method to reduce effort. These operation periods are modelled independently and cannot interact in most cases. Consequently, seasonal storage is not reproducible. This inability can lead to a significant error, especially for energy systems with a high share of fluctuating renewable energy. The previous paper, “Time series aggregation for energy system design: Modeling seasonal storage”, has developed a seasonal storage model to address this issue. Simultaneously, the paper “Optimal design of multi-energy systems with seasonal storage” has developed a different approach. This paper aims to review these models and extend the first model. The extension is a mathematical reformulation to decrease the number of variables and constraints. Furthermore, it aims to reduce the calculation time while achieving the same results.
Types of indigenous vegetables consumed, preparation, preferences and perceived benefits in Ghana
Authors: Atuna Richard A. , Djah Jemima , Achaglinkame Matthew A. , Bakker Sanne , Dari Linda , Osei-Kwarteng Mildred , Mahunu Gustav K. , Koomen Irene , Amagloh Francis K. 
Published: September 2022

AbstractIndigenous vegetables (IVs) are rich sources of essential nutrients, particularly vitamins and minerals, and other non-nutritive phytochemicals. IVs play a critical role in the food culture of the Ghanaian people. Despite their importance, they have over the years been mostly associated with the resource-poor. In this study, the types of IVs, preparation preferences, frequency of consumption and some perceived benefits ascribed by some Ghanaian consumers (n = 1393) were investigated in a cross-sectional survey. Descriptive analysis and a chi-square test of independence were conducted to summarise and determine the relationship between gender, age and consumption frequency of the IVs. The study identified okra (Abelmoschus esculentus), cocoyam (Xanthosoma sagittifolium) leaves, jute mallow (Corchorus olitorius) and garden egg (Solanum melongena) as the popular IVs consumed by respondents. Among these, about 13.3% of women and 15.3% of men indicated they consume okra. Eight per cent of the women respondents and 6.7% of the men consumed jute mallow. Almost 57% of the respondents said the IVs were used to prepare stew and soup. More than a third (39%) of the respondents indicated that they consumed the IVs either daily or more than once a week. Women respondents’ frequency of IVs consumption was significantly different [X2 (4, n = 1393) = 30.11, p = 0.000] from the men. The frequency of consumption of IVs for the elderly was significantly higher [X2 (12, n = 1393) = 30.53, p = 0.002] as compared to the younger respondents. The main perceived benefits of IVs were nutrition- and health-related. The major barriers to the consumption of IVs were cost, non-availability, palatability and cultural. The IVs were largely wet-cooked and consumed as stews or sauces and soups. These findings form good bases for further empirical studies on the nutritional and other health-benefiting attributes of the specific IVs found in this study for sustainable promotion and utilisation in Ghana.
Research on co-disposal and utilization of ferrous packaging containers contaminated with hazardous wastes by steel converter
Authors: Wang Yi , Chen Junfu , Fu Benquan , Zhang Lei , Liu Heng , Huang Yanjun , Song Guangsen 
Published: September 2022

AbstractThe disposal of waste oil, paint and coating barrels (WOPCBs) after use is an ongoing social and environmental problem. In this paper, a novel technological scheme using steel converter co-processing is proposed for the safe disposal and resource utilization of WOPCBs. The scheme is mainly composed of WOPCBs pretreatment and converter disposal, focusing on the impact of converter co-processing WOPCBs on the environment and production process. Compared to the traditional technology, the scheme presented takes full advantages of the production process and environmental protection facilities of steel converter, and has many advantages, such as a large disposal capacity, low cost, highly efficient and environmentally friendly. The industrial trials results show that after adding 180–540 kg WOPCBs to each furnace load (nominal capacity 250 t), the converter operation is safe and controllable, and all the pollutant emission indicators generated in the process meet the Chinese national standards. In addition, WOPCBs are suitable to be used as a supplementary material for scrap steel. Therefore, this study provides important insights for sustainable resource utilization from WOPCBs.
Outcomes of urgent coronary artery bypass grafting in patients who have recently recovered from COVID-19 infection, with a median follow-up period of twelve months: our experience
Authors: Bhattacharya Sudipto , Bandyopadhyay Ashok , Pahari Satyabrata , Das Sankha , Dey Ashim Kumar 
Published: September 2022

Abstract
Background
The Coronavirus disease 2019 (COVID-19) was declared a worldwide pandemic in 2020 by the World Health Organization (WHO). Certain individuals are at higher risk, (age > 65 years, pre-existing lung or heart conditions, diabetes and obesity) especially those requiring cardiac surgery, including Coronary Artery Bypass Grafting (CABG). Here we present a case series of 11 patients, operated between April 2020 and April 2022, all of whom had recently recovered from COVID-19, who presented with unstable angina, and therefore required urgent Coronary Artery Bypass Grafting (CABG). Similar cases reported in the past, have had a high morbidity and mortality rate.

Case presentation
The study included 11 males, and their age varied between 53 and 68 years (median of 65 years). They were either partially or fully vaccinated. All of them had a history of recent mild COVID-19 infection. The European system for cardiac operative risk evaluation, EuroSCORE II in-hospital mortality risk at admission, varied between 1.48% and 5.12%. Six out of 11 patients (54.55%) had a recent Acute Coronary Syndrome (ACS) which is associated with a higher risk and poor prognosis. All of them underwent urgent CABG (10 of them, 90.91% cases, using the off-pump technique and one patient had to be converted to the on-pump beating heart surgery technique during surgery). Ten of the 11 patients were operated using the off-pump technique, and there was one death (9.09%). All surviving patients made an uneventful recovery and have been followed up with a median follow-up period of 12 months.

Conclusions
Previous studies on a similar group of patients have resulted in high morbidity and mortality. A conscious effort was made to perform all surgeries off-pump, thereby eliminating the inflammatory effects and other hazards of cardiopulmonary bypass in this case series, with only one out of 11 (9.09%) being converted to the on-pump beating heart technique due to the hemodynamic instability faced during surgery. Our findings show a mortality rate of 9.09%, with the surviving patients doing well at a median follow-up period of 12 months, suggesting that it is a safe procedure in this patient subset.
Differences in Pretreatment Frailty Across Gastrointestinal Cancers in Older Adults: Results From the Cancer and Aging Resilience Evaluation Registry
Authors: Arora Sankalp , Fowler Mackenzie E. , Harmon Christian , Al-Obaidi Mustafa , Outlaw Darryl , Hollis Robert , Gbolahan Olumide , Khushman Moh'd , Giri Smith , Williams Grant R. 
Published: September 2022

PURPOSE: Frailty predicts poor outcomes in older adults with cancer, but how it differs between different cancer types is unknown. We examined differences in pretreatment frailty between colorectal (CRC), pancreatic, and hepatobiliary cancers. METHODS: We included older adults age 60 years or older with the above cancer types enrolled in the Cancer and Aging Resilience Evaluation registry. Frailty was defined using a 44-item Cancer and Aging Resilience Evaluation frailty index constructed on the basis of the principles of deficit accumulation (including several geriatric assessment impairments encompassing malnutrition, functional status, comorbidities, anxiety, depression, cognitive complaints, health-related quality of life, falls, ability to walk one block, interference in social activities, and polypharmacy). Multivariable logistic regression models were used to examine the adjusted odds ratio (aOR) of frailty between cancer types. RESULTS: A total of 505 patients were included (mean age 70 years, 59% male): 211 (41.8%) CRC, 178 (35.2%)pancreatic cancer, and 116 (23.0%) hepatobiliary cancer. Patients with pancreatic cancer had the highest prevalence of frailty (23.3% CRC, 40.6% pancreatic, 34.3% hepatobiliary; P = .001). Both pancreatic (aOR, 2.18; 95% CI, 1.38 to 3.45), and hepatobiliary cancer (aOR, 1.73; 95% CI, 1.03 to 2.93) were independently associated with higher odds of frailty relative to CRC. Frailty was driven by higher rates of malnutrition and instrumental activities of daily living impairments in patients with pancreatic cancer and higher number of comorbidities in patients with hepatobiliary cancer. CONCLUSION: Older adults with pancreatic and hepatobiliary cancers are at high-risk of pretreatment frailty. Early interventions to improve nutritional and functional status and optimization of comorbidities may help improve outcomes.
Toward a “Global” History of Music Theory
Authors: Martin Nathan John 
Published: September 2022

AbstractThe history of music theory, as it has usually been taught in the United States, has focused on a small canon of texts written mostly in Latin, Italian, French, and German. This article advocates a more expansive view of the subdiscipline's remit by way of three case studies. The first considers the distinction that Abū Naṣr Muḥammad ibn Muḥammad al-Fārābī draws between the speculative and active parts of music theory and its influence on the formation of the discipline in the Latin-speaking world. The second considers entanglement between French and Chinese music theorizing in the later eighteenth century. The third treats the international contexts of Hugo Riemann's thought. I present these three case studies, together with more general reflections on the possible scope of research on historical music theory, with the aim of inviting reflection on the subdiscipline's past, present, and future.
Interpretive Difficulty and Emergent Structure in Contemporary Music
Authors: Duinker Ben 
Published: September 2022

AbstractThis article explores the notion of interpretive difficulty in contemporary music, treating it as a structural, tangible aspect of analysis. Interpretive difficulty comprises any challenge a performer may encounter—physical, cognitive, emotional, specific to a musical passage, or generalized across a repertoire or performance idiom. Five professional performers who specialize in contemporary music are interviewed about their experiences learning and performing specific works—Crimson (Rebecca Saunders, 2005), Taurangi (Gillian Whitehead, 1999), Mani.Δίκη (Pierluigi Billone, 2012), Sept papillons (Kaija Saariaho, 2000), and La Nativité du Seigneur (Olivier Messiaen, 1935)—focusing on how interpretive difficulty and musical structure intersect in their practice. These interviews illuminate a relationship between interpretive difficulty and musical structure that manifests in several domains: accuracy, interpretive latitude, narrative, and control. While difficulty is uniquely determined by any musician's physical, cognitive, environmental, or cultural context, using these domains as a theoretical framework establishes relationships among works, performers, and idioms that might otherwise appear to have little in common—a particularly appealing prospect for recently composed repertoire. In subscribing to Nicholas Cook's (2013) recharacterization of the score as a “script” that is interpreted, supplemented, and molded in performance, this research encourages the treatment of performers' contributions as a fundamental object of analysis.
Targeting firing rate neuronal homeostasis can prevent seizures
Authors: Mulroe Fred , Lin Wei-Hsiang , Mackenzie-Gray Scott Connie , Aourz Najat , Fan Yuen Ngan , Coutts Graham , Parrish R. Ryley , Smolders Ilse , Trevelyan Andrew , Wykes Robert C. , Allan Stuart , Freeman Sally , Baines Richard A. 
Published: September 2022

ABSTRACT
Manipulating firing-rate neuronal homeostasis, which enables neurons to regulate their intrinsic excitability, offers an attractive opportunity to prevent seizures. However, to date, no drug-based interventions have been reported that manipulate this type of neuronal homeostatic mechanism. Here, we used a combination of Drosophila and mouse, and, in the latter, both a pentylenetetrazole (PTZ)-induced seizure model and an electrically induced seizure model for refractory seizures to evaluate the anticonvulsant efficacy of a novel class of anticonvulsant compounds, based on 4-tert-butyl-benzaldehyde (4-TBB). The mode of action included increased expression of the firing rate homeostatic regulator Pumilio (PUM). Knockdown of pum expression, in Drosophila, blocked anticonvulsive effects of 4-TBB, while analysis of validated PUM targets in mouse brain revealed significant reductions following exposure to this compound. A structure-activity study identified the active parts of the molecule and, further, showed that the pyrazole analogue demonstrates highest efficacy, being active against both PTZ-induced and electrically induced seizures. This study provides a proof of principle that anticonvulsant effects can be achieved through regulation of firing rate neuronal homeostasis and identifies a possible chemical compound for future development.
Synergizing liver systemic treatments with interventional oncology: friend or foe?
Authors: Jost Raphaël , Al-Shatti Nael , Ghosn Mario , Bonnet Baptiste , Champiat Stephane , Deschamps Frederic , Gelli Maximiliano , Boige Valérie , Danlos Francois-Xavier , Susini Sandrine , Hollebecque Antoine , Ammari Samy , Marabelle Aurelien , de Baere Thierry , Tselikas Lambros 
Published: September 2022

Interventional radiology techniques provide excellent local tumor control for small tumors in various organs, but several limitations can hamper the oncological outcomes such as the tumor size or the number of lesions. Technical improvements, optimal patient selection and combination with systemic therapies, including immune checkpoint inhibitors, have been successfully developed to overcome these barriers.
In this setting, chemotherapy and targeted therapies aim to diminish the tumor burden in addition to local treatments, while immunotherapies may have a synergistic effect in terms of mechanism of action on the tumor cell as well as the immune environment, with multiple treatment combinations being available. Finally, interventional Rrdiology treatments often increase tumor antigen exposure to the immune system, and thus stimulate a specific antitumor immune response that can act beyond the treated site. Notwithstanding their many benefits, combination treatment may also result in complications, the most feared may be auto-immune-related adverse events.
In early studies, several combined therapies have shown promising levels of safety and efficacy, particularly in hepatocellular carcinoma.
This review provides a comprehensive and up-to-date overview of results of combined therapies for primary and secondary liver malignancies. Recent advances and future perspectives will be discussed.
Many-Server Heavy-Traffic Limits for Queueing Systems with Perfectly Correlated Service and Patience Times
Authors: Yu Lun , Perry Ohad 
Published: September 2022

We characterize heavy-traffic process and steady-state limits for systems staffed according to the square-root safety rule, when the service requirements of the customers are perfectly correlated with their individual patience for waiting in queue. Under the usual many-server diffusion scaling, we show that the system is asymptotically equivalent to a system with no abandonment. In particular, the limit is the Halfin-Whitt diffusion for the [Formula: see text] queue when the traffic intensity approaches its critical value 1 from below, and is otherwise a transient diffusion, despite the fact that the prelimit is positive recurrent. To obtain a refined measure of the congestion due to the correlation, we characterize a lower-order fluid (LOF) limit for the case in which the diffusion limit is transient, demonstrating that the queue in this case scales like [Formula: see text]. Under both the diffusion and LOF scalings, we show that the stationary distributions converge weakly to the time-limiting behavior of the corresponding process limit. Funding: This work was supported by the National Natural Science Foundation of China [Grant 72188101] and the Division of Civil, Mechanical and Manufacturing Innovation [Grants 1763100 and 2006350].
Stochastic Zeroth-Order Riemannian Derivative Estimation and Optimization
Authors: Li Jiaxiang , Balasubramanian Krishnakumar , Ma Shiqian 
Published: September 2022

We consider stochastic zeroth-order optimization over Riemannian submanifolds embedded in Euclidean space, where the task is to solve Riemannian optimization problems with only noisy objective function evaluations. Toward this, our main contribution is to propose estimators of the Riemannian gradient and Hessian from noisy objective function evaluations, based on a Riemannian version of the Gaussian smoothing technique. The proposed estimators overcome the difficulty of nonlinearity of the manifold constraint and issues that arise in using Euclidean Gaussian smoothing techniques when the function is defined only over the manifold. We use the proposed estimators to solve Riemannian optimization problems in the following settings for the objective function: (i) stochastic and gradient-Lipschitz (in both nonconvex and geodesic convex settings), (ii) sum of gradient-Lipschitz and nonsmooth functions, and (iii) Hessian-Lipschitz. For these settings, we analyze the oracle complexity of our algorithms to obtain appropriately defined notions of ϵ-stationary point or ϵ-approximate local minimizer. Notably, our complexities are independent of the dimension of the ambient Euclidean space and depend only on the intrinsic dimension of the manifold under consideration. We demonstrate the applicability of our algorithms by simulation results and real-world applications on black-box stiffness control for robotics and black-box attacks to neural networks. Funding: J. Li and S. Ma acknowledge the support of the National Science Foundation (NSF) [Grants DMS-1953210, CCF-1934568, and CCF-2007797]. K. Balasubramanian acknowledges the support of the NSF [Grant DMS-2053918]. K. Balasubramanian and S. Ma acknowledge the support of the UC Davis CeDAR (Center for Data Science and Artificial Intelligence Research) Innovative Data Science Seed Funding Program.