bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant and antimicrobial properties of polyphenolics fromWithania adpressa(Coss.) Batt. against selected drug-resistant bacterial strains
Authors: Salamatullah Ahmad Mohammed 
Published: June 2022

AbstractWithania adpressa(Coss.) Batt. (W. adpressa) is a wild medicinal plant in the family Solanaceae, which is used as an alternative medicine. The present study aims to investigate the chemical composition, antioxidant, and antibacterial potentials of polyphenol-rich fraction from the leaves ofW. adpressa. Polyphenol-rich fraction was characterized by use of high-performance liquid chromatography (HPLC). Antioxidant potency was determined by use of 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and total antioxidant capacity (TAC) assays. Antibacterial activity was assessed against gram-positive and gram-negative bacteria by use of disc diffusion and microdilution assays. Chromatographic analysis by HPLC showed four compounds in the polyphenol-rich fraction including 1-O-Caffeoyl glucose, Luteolin-7-diglucuronide, Apigenin-O-pentoside, and Quercetin-3-O-glucuronide. Polyphenol-rich fraction exhibited important antioxidant activity as assessed by DPPH and FRAP assays, with IC50and EC50values of 14.27 ± 0.43 and 39.48 ± 0.81 µg/mL, respectively, while butylated hydroxytoluene (BHT) and Quercetin exhibited IC50values of 28.92 ± 0.24 and 22.48 ± 0.54 µg/mL. Results of TAC showed that the polyphenol-rich fraction scored 781.74 ± 2.83 µg AAE/mg. Polyphenol-rich fraction showed an important antibacterial effect vs gram-positive and gram-negative strains recording inhibition zone diameters varying from 19.5 to 29.2 mm, while antibiotics were almost ineffective toward all strains except forE. coli. It can be concluded thatW. adpressapolyphenol-rich fraction possesses promising phenols with strong antioxidant and antibacterial properties, which may help fight pathogenic bacteria and free radicals.
Cu-foil modification for anode-free lithium-ion battery from electronic cable waste
Authors: Ikhsanudin Muhammad Nur , Al Ichwan Abdur Rochim , Kuncoro Dimas Dwi , Muthi Annisa Salsabila Ghina , Jamaluddin Anif , Purwanto Agus 
Published: June 2022

Abstract
Batteries are a very efficient energy source used in an all-digital environment that adapts to today’s human mobility. The lithium-ion battery is one of the batteries used in various household appliances. There are some problems caused by the anode in terms of utility. This is due to high electrochemical reactivity, which can reduce battery performance. One of the innovations in lithium-ion batteries is anode-free Li-ion battery (AFLB). The working mechanism of this battery is the same as the previous Li-ion battery, but with a smaller anode capacity, so that it can reduce the volume (large) of the battery. The problem that arises is the growth of dendrites that interferes with the battery’s running mechanism, so it needs to be evaluated for its growth. The way that can be done is to modify the copper foil by adding Cu. The innovation of this research is to modify Cu-foil by adding Cu from cable waste. The research method used is leaching Cu from cable waste, followed by reducing Cu powder to form a modified Cu. This study’s data collection techniques include empirical research derived from previous studies and instrumental analysis using SEM, FTIR, and electrochemical performance tests. Electrochemical testing using a cylindrical battery with a current of 1 C (1 C = 430 mA g−1) and a voltage of 2.6–4.3 V obtained ALFB and ALFB Cu-modification batteries with a discharge capacity of 70 and 123 mA h g−1, respectively.
Polyurethane-based retanning agents with antimicrobial properties
Authors: Ding Sheng , Zhu Jinxing , Tian Saiqi 
Published: June 2022

Abstract
Polyurethane-based retanning agents with antimicrobial properties were synthesized by the chemical incorporation of ciprofloxacin (CPFX) units into polyurethane chains. The chemical structures were characterized by Fourier transform infrared (FTIR) and gel permeation chromatography (GPC). Then, the retanning agents were applied in the leather retanning process. Owing to the conjugation of CPFX into polyurethane chains, the molecular weight increases, further leading to the decrease in hydroxyl value and increase in particle size. The shrinkage temperature was improved after retanning. Owing to the filling of retanning agents in the gap of collagen fibers, the average thickness of leather increased by 65.8%. The mechanical properties of leather were visibly improved because of the large number of –COOH coordinate with Cr3+ and more hydrogen crosslinking with carboxyl group, amino group, and hydroxyl group of leather collagen. Furthermore, leather retanned by these polyurethane-based retanning agents presented good antimicrobial properties. The antibacterial activity could be conserved above 89% even after rinsing for ten times.
Embracing Donald Trump’s Big Lie and Making Voting Harder Are Republicans Sure They Know What They are Doing?
Authors: Stonecash Jeffrey M. 
Published: June 2022

Abstract
Following the 2020 presidential election Donald Trump claimed that the election had been stolen and that fraud was widespread. His voter base widely accepted that and that has prompted numerous state legislatures to enact laws creating hurdles that make voting more difficult. The presumption of most reactions to these laws is that they are directed at reducing non-white voting. This study suggests that they may also affect the white working class. The party needs their votes and they have a historical record of not voting at high levels. More hurdles may diminish their turnout. The analysis draws on voting patterns from 1952–2020.
Effects on hand-sheet paper properties of pH in deinking process
Authors: Sonmez Sinan , Wu Qingliu , Fleming Paul D. , Pekarovicova Alexandra 
Published: June 2022

Abstract
In today’s world where natural resources are rapidly decreasing, recycling printed papers, and their use in paper production will reduce the environmental pollution caused by waste paper. Thus, energy savings can be achieved with less energy consumption. Although many methods are used in the deinking of printed papers, the effectiveness of these methods varies depending on many parameters, such as the type of paper to be de-inked, the type of printed ink in the printing system, and the chemicals used in deinking. In this study, the effect of pH in the deinking process was studied. Electrophotographic printed papers were used as the printed paper in this study, and the INGEDE method was applied as the deinking method. In this method, 3 different pH environments were prepared and an ink removal process was carried out in this environment. Optical and physical properties were determined by producing hand-sheet papers from the deinked pulp. In addition, test prints were made to determine the printability of the produced hand-sheet papers in the electrophotographic printing system.
Scalable multi-distance measurement approach for the optical assessment of tooth-individual shape parameters of large gearings
Authors: Pillarz Marc , von Freyberg Axel , Fischer Andreas 
Published: June 2022

Abstract
The demand for scalable measuring systems for the fast measurement of tooth-individual shape parameters of large gears is increasing. Due to a limited measuring speed and a limited measuring volume, standard tactile gear measuring systems are only conditionally suitable for comprehensive measurements of large gears. Therefore, the applicability of a scalable optical multi-distance measurement approach consisting of an optical sensor and a rotary table with a model-based evaluation is studied. As a fundamental gear shape parameter, the base circle radius of a large gearing is evaluated and the achievable measurement uncertainty is estimated. As a result, the tooth-individual base circle radius is determined on average with an expanded measurement uncertainty (k = 2) of one quarter of the required tolerance, and the realized measurement setup enables the measurement of all teeth within 1 minute. Hence, the scalable optical multi-distance measurement approach is appliacable for the fast measurement of tooth-individual shape parameters of large gearings.
Conformity assessment of photo-optical measurement data registration in legal metrology
Authors: Esche Marko , Nischwitz Martin , Schmidt Manuel , Meyer Reinhard , Elfroth Marco 
Published: June 2022

Abstract
The rollout of smart meters in Europe requires solutions for the transition from the existing metering system to the digital metering infrastructure. Connecting legacy meters to the new digital backends is one of the major challenges for the transitory phase. Here, the requirements for performing valid registration of measurement values from legacy meters are derived from the legal metrological framework of the European Union. Threats on the process of registration are then determined based on these requirements and subsequently evaluated. A prototypical implementation, making use of photo-optical technology is presented, illustrating how applicable requirements may be covered. With the help of a risk assessment, the critical aspects of the implementation are identified to highlight how actual implementations might be further improved.
Preliminary study on pathogenic mechanism of first Chinese family with PNKD
Authors: Chen Feng , Zhang Shaohui , Liu Tinghong , Yuan Liu , Wang Yangshuo , Zhang Guojun , Liang Shuli 
Published: June 2022

Abstract

Background
The first Chinese family with paroxysmal non-kinesigenic dystonia (PNKD) was confirmed to harbour a PNKD mutation. However, the pathogenic mechanism of the PNKD-causing gene mutation was unclear.

Methods
Wild-type and mutant PNKD-L plasmids were prepared and transfected into the C6 cell line to study the distribution and stability of PNKD protein in C6 cells and its effect on the glutathione content. The blood and cerebrospinal fluid (CSF) of 3 PNKD patients and 3 healthy controls were collected. The differentially expressed proteins were identified using isobaric tags for relative and absolute quantitation. Furthermore, Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment analyses were performed, and the protein–protein interaction network was constructed.

Results
Wild-type PNKD protein was mainly distributed in the membranes, whereas mutant PNKD protein was distributed throughout the C6 cells. After transfection with mutant PNKD-L plasmid, the glutathione content decreased significantly in C6 cells; the stability of the mutant PNKD protein was significantly low. There were 172 and 163 differentially expressed proteins in CSF and plasma, respectively, of PNKD patients and healthy controls. For these proteins, blood microparticle and complex activation (classical pathway) were the common GO enrichment term, and complex and coordination cascade pathway were the common KEGG enrichment pathway. Recombinant mothers against decapentaplegic homolog 4 (SMAD4) was one of the differentially expressed proteins; it exhibited a relationship with the aforementioned enrichment GO terms and KEGG pathway.

Conclusion
PNKD protein was mainly distributed in cell membranes. PNKD-L mutation affected subcellular localisation, PNKD protein stability, and glutathione content. SMAD4 was found to be a potential biomarker for PNKD diagnosis.
Violencias basadas en el género (VBG), feminicidio y transfeminicidio: categorías de análisis sociológico necesarias para materializar una justicia con enfoque de género tras la pandemia del covid-19
Authors: Bahamón Jara Martha Lucía , Ruiz Aroyave Javier Omar , Tirado Acero Misael 
Published: June 2022

En el marco de la pandemia mundial de covid-19 y la cuarentena decretada desde el 24 de marzo del 2020 en el territorio nacional colombiano, como reacción y contención de la emergencia sanitaria, surge una segunda alerta nacional, esta vez por feminicidios en Colombia. La magnitud de las cifras de los feminicidios perpetrados y el hecho de que tan solo un día después de la declaración presidencial de cuarentena obligatoria se cometiera un triple feminicidio en la ciudad de Cartagena evidencian que la violencia contra las mujeres es otra emergencia mortal creciente y socialmente arraigada.
Por tanto, la investigación de la cual se deriva el presente texto busca incorporar al ejercicio jurídico un análisis sociológico de los feminicidios y transfeminicidios, para comprender las dificultades institucionales, la brecha entre las medidas de protección y la complejidad de la violencia patriarcal. Con esto se quiere fortalecer herramientas institucionales que materialicen el marco de derechos a las mujeres y personas diversas, a partir de la caracterización y comprensión de las condiciones que envuelven el fenómeno del feminicidio como expresión máxima de la violencia patriarcal, observando estudios doctrinales y normativos, como referentes jurisprudenciales. Así, se pretende contribuir a la discusión observando cómo la institucionalidad concibe y enfrenta al fenómeno del feminicidio, para impactar en los mecanismos de protección y la efectividad de la administración de justicia y enfrentar de manera idónea la actual alerta nacional por feminicidios.
La economía familiar en el contexto del covid-19
Authors: Ordaz Hernández Mónica Berenice , Antonio Pacheco Belizario , Alonso Guillén Amado 
Published: June 2022

El presente trabajo pretende diagnosticar la percepción de los estudiantes de la Facultad de Contaduría y Administración, Campus Coatzacoalcos, de la Universidad Veracruzana, con relación a su economía familiar en el contexto del covid-19. El estudio cuenta con un enfoque cuantitativo y con un alcance descriptivo y es de corte transversal. En cuestión a la construcción del instrumento, se fusionó la versión corta y adaptada del cuestionario diseñado por Cheung y Lucas (2014, citados en Romero y Matamoros, 2020) “Satisfaction with Life Scale” y la Encuesta sobre el impacto de la COVID-19 en las familias, realizada por Plena Inclusión Madrid (2020). Esta fusión resultó en un instrumento de 20 ítems, dividido en datos demográficos y en dos dimensiones que responden a la situación económica familiar y laboral en el contexto del covid-19. Entre los resultados, sobresalen que el 50 % de los hogares presentan reducción de los ingresos y aumento de gastos extras y afectación al acceso a los servicios básicos, que el 25 % ha sido separado de su empleo de manera definitiva y que el 28 % ha sido suspendido temporalmante, en ese sentido se concluye que, por parte del Estado, se deben fortalecer las politicas públicas.
Las perspectivas eclesiológicas del papa Francisco según la Fratelli tutti
Authors: Tabares Ríos Jorge Andrés 
Published: June 2022

Desde su elección en 2013, el Papa Francisco ha sorprendido al mundo por su espontaneidad, sus palabras y sus gestos. Ha renunciado a vestir de forma ostentosa, se interesa por los pobres, marginados, excluidos, y desea renovar la Institución eclesial. Sus primeros discursos se centraron en el concepto de la misericordia hasta el punto que convocó un jubileo extraordinario recordando que el ser misericordioso es la vocación principal de todo discípulo misionero de Jesús. El Papa Bergoglio tiene claro que la Iglesia debe estar abierta a la renovación, al cambio y como fruto de ese deseo eclesial es la Carta Encíclica Fratelli Tutti, publicada el 3 de octubre de 2020. En dicho documento no encontramos temas de índole teológico, dogmático, canónico, sacramental. El Papa no dice nada sobre la sinodalidad, ni denuncia pecados de moral sexual, ni se detiene en detalles de cómo recibir la comunión eucarística. Ese no ha sido su estilo. Lo que el Sumo Pontífice desea y espera de la Iglesia católica es que salga de su encierro y falsas seguridades, que no pase de lado, no ignore, ni se desentienda de los demás. Más bien, que esté al servicio de la fraternidad y amistad social.
Decolonial approach to the intercultural bilingual curriculum:
Authors: Soto Molina Jairo , Méndez Rivera Pilar Esther 
Published: June 2022

This reflection article is intended to reflect upon the benefits of a decolonial intercultural approach to the EFL curriculum. As interculturality is opposed to multiculturality, a distinction between these two frames is pivotal to cast light upon linguistic colonialism practices and other forms of power-knowledge colonial matrix in some curriculum designs. Interculturality suggests interaction, respect, and recognition among cultures, while multiculturality involves the co-presence of several separated cultures, competing to hegemonize or control other cultures. Although, the former has much more acceptance, the decolonial critique to interculturality might offer a problematization of a widely restrictive view of mainstream interculturality. With awareness of these counterforces, this article discusses how interculturality can be used to decolonize the only English curriculum to give other senses to the bilingual curriculum.
Pertinencia de la certificación de competencias laborales del instructor: caso de un centro de formación en diseño, confección y moda
Authors: Velásquez Restrepo Sandra Milena , Giraldo Vásquez Diego Hernán 
Published: June 2022

Este trabajo estudia el nivel de certificación en normas sectoriales de competencia laboral de los instructores de un centro de formación en diseño, confección y moda, y el aporte de dichas competencias a la formación impartida. Se analizó la cadena de valor del sector al que se asocian los programas de formación ofrecidos, se identificaron las normas de competencia requeridas para las ocupaciones misionales del sector y se diagnosticó el nivel de certificación de los instructores. Se encontró que la mayoría de instructores se habían certificado tanto en competencias específicas del sector como en competencias asociadas a su labor como educadores. También se identificó que hay una alta proporción de certificaciones vencidas y que en algunas normas no se cuenta con instructores certificados, por lo que se presenta una reflexión sobre la manera como la certificación de competencias de los instructores puede mejorar la pertinencia de la formación impartida.
The effect of Dulaglutide on glycemic and weight control in patients with type 2 diabetes
Authors: Ruda Alexandru Ioan , Ciobanu Dana Mihaela , Inceu Georgeta , Rusu Adriana , Roman Gabriela 
Published: June 2022

Background and aims. The objectives of type 2 diabetes treatment are to achieve adequate long-term glycemic control and to reduce the risk associated with comorbidities and complications. Once-weekly Dulaglutide showed a reduction in cardiovascular risk associated with diabetes in addition to improved glycemic control and bodyweight reduction in several clinical trials. We aimed to investigate the effect of Dulaglutide 1.5 mg on glycemic and weight control in type 2 diabetes patients inadequately controlled by antihyperglycemic treatment in real-world clinical practice.
Methods. We retrospectively reviewed the medical records of 50 patients with type 2 diabetes inadequately controlled by previous treatment and newly initiated on Dulaglutide. The data were collected at 6 months (n=50) and 12 months (n=40) after Dulaglutide therapy initiation.
Results. Dulaglutide treatment resulted in significant improvement of glycated hemoglobin (−1.3 %; p<0.001) after 6 months and after 12 months (−2.0 %; p<0.001). Significant bodyweight reduction was found after 6 months (−2.0 kg; p=0.002) and 12 months (−3.5 kg; p=0.001) of Dulaglutide treatment initiation. In addition, a reduction in insulin dose was observed.
Conclusions. Our clinical data showed that Dulaglutide 1.5 mg significantly improved glycemic and bodyweight control at 6 and 12 months after treatment initiation in patients with type 2 diabetes inadequately controlled by previous antihyperglycemic treatment.
Feasibility of a Centralized, Pharmacy-Led Penicillin Allergy Delabeling Program
Authors: Antoon James W. , Grijalva Carlos G. , Grisso Alison G. , Stone Cosby A. , Johnson Jakobi , Stassun Justine , Norton Allison E. , Kripalani Sunil , Williams Derek J. 
Published: June 2022

BACKGROUND
Penicillin allergy labels are often inaccurate in children and removing unnecessary labels results in improved outcomes and lower health care costs. Although the hospital setting is a frequent point of contact for children, strategies to evaluate penicillin allergies in the hospital are lacking.

METHODS
We performed a prospective pilot study to determine the feasibility of a centralized, pharmacy-led approach to penicillin allergy evaluation. Children with a reported history of penicillin allergy admitted to our children’s hospital were risk-stratified and those stratified as low-risk underwent a single-dose oral challenge by a central pharmacist, regardless of the need for antibiotics. After the completion of each patient’s delabeling process, surveys were distributed to health care personnel involved in the patient’s care to collect perceptions on the acceptability, appropriateness, and feasibility of this intervention. Measures were scored by using a 5-point Likert scale.

RESULTS
Of the 23 patients who screened as low-risk, 20 underwent a penicillin allergy evaluation and an oral challenge. Of these, the penicillin allergy label was removed in 19 (95%) patients (Fig 1). The median age was 7 years (range 11 months–18 years). Participants rated the risk stratification and delabeling favorably overall, with high ratings on all 3 implementation measures: acceptability (mean 4.55, ± standard deviation [STD] 0.65), appropriateness (mean 4.58, STD ± 0.6), and feasibility (mean 4.51, STD ± 0.73). Measures of acceptability, appropriateness, and feasibility remained high when stratified by health care worker type and provider type.

CONCLUSIONS
Our findings provide support for systemic implementation of penicillin allergy delabeling strategies in hospitalized children.
Bentuk Ajaran Syekh Maulana Ibrahim Al-Khalidi Kumpulan Dalam Menyebarkan Islam di Minangkabau (Tinjauan Historis)
Authors: Ayu Nanda Mustika  , Muslim Kori Lilie , Miswar Munir  
Published: June 2022

Penelitian ini dilatar belakangi oleh hilangnya arti perjuangan seorang ulama yang terdahulu karena konteks kehidupan saat ini semakin berkembang, orang-orang saat ini sudah mulai melupakan arti perjuangan seorang ulama terdahulu yaitu Syekh Maulana Ibrahim Al-Khalidi Kumpulan. Karena pada dasarnya Syekh Maulana Ibrahim Al-Khalidi telah berhasil melakukan perubahan ditengah-tengah masyarakat, yang pada masa itu berkembang kebiasaan-kebiasaan buruk yang bertentangan dengan ajaran agama Islam, seperti perjudian, menyabung ayam, mengisap madat (narkoba). Penelitian ini menggunakan metode sejarah dalam bentuk deskriptif naratif (kualitatif). Penelitian ini dilakukan di Nagari Kumpulan. Sumber primer yang digunakan yaitu naskah Syekh Said Bonjol dan melakukan teknik wawancara dan observasi.Hasil yang diperoleh dari penelitian, dalam proses menyebarkan agama Islam awalnya Syekh Maulana Ibrahim Al-Khalidi Kumpulan mendirikan intitusi sebagai tempat ia beraktifitas. Syekh Maulana Ibrahim Al-Khalidi mendirikan surau yang kemudian ia beri nama surau Kaciak(kecil), sesuai dengan bentuk dan ukurannya. Syekh Maulana Ibrahim Al-Khalidi Kumpulan menyebarkan agama Islam kepada masyarakat Kumpulan melalui ajaran tarekat Naqsyabandiyah. Ajaran yang dibawa oleh Maulana Ibrahim Al-Khalidi dalam menyebarkan Islam terhadap masyarakat Kumpulan, secara berangsur-angsur masyarakat Kumpulan mulai meninggalkan kebiasaan jelek melalui ajaran yang disampaikan oleh Syekh MaulanaIbrahim Al-Khalidi.