bluuebunny/crossref_metadata_2025_split huggingface dataset:
Black hole shadow in f(R) gravity with nonlinear electrodynamics*
Authors: Sun Jiaojiao , Liu Yunqi , Qian Wei-Liang , Chen Songbai , Yue Ruihong 
Published: November 2022

Abstract
By analyzing the propagation of discontinuity in nonlinear electrodynamics, we numerically investigate the related black hole shadows of recently derived rotating black hole solutions in

gravity. In this context, the geodesic motion of the relevant perturbations is governed by an effective geometry, which is closely related to the underlying spacetime metric. We derive the effective geometry, and the latter is used to determine the trajectory of the propagation vector of an arbitrary finite discontinuity in the electrodynamic perturbations, namely, the photon. Subsequently, the image of the black hole is evaluated using the ray-tracing technique. Moreover, we discuss the physical relevance of metric parameters, such as the nonlinear coupling, spin, and charge, by studying their impact on the resultant black hole shadows.
Effects of the formation time of parton shower on jet quenching in heavy-ion collisions*
Authors: Zhang Mengxue , He Yang , Cao Shanshan , Yi Li 
Published: November 2022

Abstract
Jet quenching has successfully served as a hard probe to study the properties of Quark-Gluon Plasma (QGP). As a multi-particle system, jets require time to develop from a highly virtual parton to a group of partons close to mass shells. In this study, we present a systematical analysis on the effects of this formation time on jet quenching in relativistic nuclear collisions. Jets from initial hard scatterings were simulated with Pythia, and their interactions with QGP were described using a Linear Boltzmann Transport (LBT) model that incorporates both elastic and inelastic scatterings between jet partons and the thermal medium. Three different estimations of the jet formation time were implemented and compared, including instantaneous formation, formation from single splitting, and formation from sequential splittings, before which no jet-medium interaction was assumed. We found that deferring the jet-medium interaction with a longer formation time not only affects the overall magnitude of the nuclear modification factor of jets but also its dependence on the jet transverse momentum.
Tungsten doped diamond shells for record neutron yield inertial confinement fusion experiments at the National Ignition Facility
Authors: Braun T. , Kucheyev S.O. , Shin S.J. , Wang Y.M. , Ye J. , Teslich Jr N.E. , Saw C.K. , Bober D.B. , Sedillo E.M. , Rice N.G. , Sequoia K. , Huang H. , Requieron W. , Nikroo A. , Ho D.D. , Haan S.W. , Hamza A.V. , Wild C. , Biener J. 
Published: November 2022

Abstract
We report on fabrication and characterization of layered, tungsten doped, spherical about 2 mm diameter microcrystalline diamond ablator shells for inertial confinement fusion (ICF) experiments at the National Ignition Facility. As previously reported, diamond ICF ablator shells can be fabricated by chemical vapor deposition (CVD) on solid spherical silicon mandrels using an ellipsoidal microwave plasma reactor. In the present work, we further developed these ablator shells by embedding a W-doped diamond layer sandwiched between two undoped diamond regions. W incorporation in diamond was achieved by adding tungsten hexacarbonyl to the CH4/H2 CVD feed gas. We observe that the W doping concentration decreases with increasing deposition rate which, in turn, is controlled by adjusting the total gas pressure. Cross sectional microstructural analysis reveals sharp interfaces between doped and undoped regions of the diamond shell and uniform W distribution with concentrations up to about 0.3 at.%. At higher W concentrations (>0.3 at.%) formation of tungsten carbide precipitates is observed. Using a 3‐shock 1.6 MJ laser pulse, the targets described in this work produced the first laser driven implosion to break the 1 × 1016 neutron yield barrier, followed by experiments (described in future publications) with similar targets and slightly more laser energy producing yields as high as 4 × 1017.
Preliminary consideration of the beam screen for the super
proton-proton collider
Authors: Hui X.J. , Wang J. , Hu Y.C. , Wang S. 
Published: November 2022

Abstract
This study evaluates the functional requirements of the
Super Proton-proton Collider (SPPC) beam screen in view of the
CEPC-SPPC project about to be built in China and aims to prove the
feasibility of using the scaled FCC-type beam screen. Moreover, the
study puts forward several feasible updated schemes with
extra-cooling to optimize the cryogenic efficiency under the
12.8 W/m synchrotron radiation (SR) heat load and decrease the
leaked SR power to the cold bore. The power distribution calculated
by Synrad+ is imported into the Ansys workbench to get the exact
thermal profile. The results show that the new scheme can restrict
the temperature rise within 1 K, with a 30 g/s mass flow rate of
the coolants. Such a profile can save over 1.3 MW electric power
per turn.
Engineering thixotropic supramolecular gelatin-based hydrogel as an injectable scaffold for cell transplantation
Authors: Nishiguchi Akihiro , Taguchi Tetsushi 
Published: November 2022

Abstract
Despite many efforts focusing on regenerative medicine, there are few clinically-available cell-delivery carriers to improve the efficacy of cell transplantation due to the lack of adequate scaffolds. Herein, we report an injectable scaffold composed of functionalized gelatin for application in cell transplantation. Injectable functionalized gelatin-based hydrogels crosslinked with reversible hydrogen bonding based on supramolecular chemistry were designed. The hydrogel exhibited thixotropy, enabling single syringe injection of cell-encapsulating hydrogels. Highly biocompatible and cell-adhesive hydrogels provide cellular scaffolds that promote cellular adhesion, spreading, and migration. The in vivo degradation study revealed that the hydrogel gradually degraded for seven days, which may lead to prolonged retention of transplanted cells and efficient integration into host tissues. In volumetric muscle loss models of mice, cells were transplanted using hydrogels and proliferated in injured muscle tissues. Thixotropic and injectable hydrogels may serve as cell delivery scaffolds to improve graft survival in regenerative medicine.
Spatial and temporal changes in the coupling of ecological environment and tourism development: the case of Kyushu, Japan
Authors: Liu Yiming , Suk Sunhee , Cai Yanning 
Published: November 2022

Abstract
The relationship between the ecological environment and tourism development is extremely complex. Summarizing evolutionary trends, temporal patterns and spatial differences in time and space can contribute to the coordinated development of an ecological environment and tourism. Based on the Carrying capacity–Supporting capability–Attraction capability–Evolutional capability–Development capability model and the Pressure–State–Response model, this paper proposes a conceptual index system using the entropy weight method and the coupled coordination degree model. The coupling coordination relationship between the ecological environment and tourism development in seven prefectures in the Kyushu region of Japan from 2010 to 2019 was analyzed. Then, using the membership degree model, the coordinated development of each prefecture was further analyzed. The results mainly show that in the Kyushu region, the degree of coupling coordination between the ecological environment and the tourism development system changed from moderate coordination to marginal coordination during the study period, then steadily improved, with large differences between regions. Based on the analysis results, this paper puts forward specific suggestions for the prefectures with lagging tourism development and lagging ecological environment development, respectively, to provide a reference path for the sustainable development of the ecological environment and tourism in the Kyushu region. For prefectures in the ecological environment development lag-type stage, the following requirements were identified: (a) the need for the government to strengthen tourism infrastructures; (b) the need for the government to focus on developing regional ecotourism, focusing on the fragility of island ecosystems and the sustainability of resources in the Kyushu region; (c) the need for the government to scientifically formulate tourism-related policies and plan tourism-related investments. For prefectures in the tourism development lag-type stage, the following were identified: (a) the need for the government to develop a variety of tourism products and create regional tourism brands based on local conditions; (b) prefectures should determine the main tourism functions and themes it offers based on the specifics of their resource advantages.
Use of a Vanadate Oxidation Conjugated Bilirubin Assay to Reduce Test Cancellations Resulting from Hemolyzed Specimens in Pediatric Patients
Authors: Kaumeyer Benjamin A , Tjota Melissa Y , Parker Kyle , Chan Clarence W , Gant Kanegusuku Anastasia , Baldwin Angel D , Yeo Kiang-Teck J 
Published: November 2022

Abstract

Objectives
We sought to replace the highly hemolysis-susceptible diazo conjugated bilirubin (Bc) assay with the more robust vanadate oxidation method and determine its impact on test cancellation in the pediatric population.

Methods
Analytical validation of the Randox vanadate assay and comparison with the Roche diazo method were performed. The frequency of pediatric sample cancellation because of hemolysis was compared between the diazo and vanadate methods by retrospective analysis of clinical test data.

Results
The vanadate assay demonstrated no clinically significant interference from hemolysis up to a hemolysis index of 1,300 (approximately 13 g/L hemoglobin). There was a strong correlation with the diazo method (r2 = 0.97) but with a positive slope bias of 1.27. Implementing the vanadate method resulted in a significantly lower proportion of pediatric samples cancelled because of hemolysis compared with the diazo method (0.6% of 688 patients vs 30.6% of 10,464 patients, respectively; P &lt; .001), with a 0.6% (n = 513) vs 43.2% (n = 6,464) reduction in test cancellations (P &lt; .001) for children younger than 6 months of age.

Conclusions
The vanadate method showed robust performance against hemolysis. Its implementation resulted in a significant decrease in pediatric tests cancelled because of hemolysis.
Toward an Integrated Understanding of Language Use in Health Communication: Discourse-analytic and Message Design Approaches
Authors: Jia Mian 
Published: November 2022

Abstract
Applied linguists and Communication scholars have mainly adopted different yet complementary approaches to research on language and health communication. Using discourse-analytic (DA) approaches such as conversation analysis and corpus analysis, applied linguists tend to focus on describing and explicating health messaging techniques in naturally occurring interactions. In contrast, communication scholars favour message design (MD) approaches that compare the effects of different message features on participants’ perceptions, attitudes, and behavioural intentions. Drawing on examples from interpersonal medical consultation and public health campaign, I demonstrate that an integration of these two paradigms is beneficial for creating a holistic understanding of research on language and health communication. Specifically, the DA paradigm offers rich descriptions of social actions in terms of their organizational structures and linguistic realizations, whereas the MD paradigm quantitatively assess the impact of particular messaging strategies. The challenges and opportunities of this integration are also discussed.
A Canadian Experience With Off-the-Shelf, Aseptically Processed, Costal Cartilage Segment Allografts in Complex Rhinoplasty
Authors: Milkovich John , Ahmad Jamil 
Published: November 2022

Abstract

Background
Complex primary and secondary rhinoplasties usually necessitate grafting materials when native nasal cartilage is inadequate for reconstruction. Fresh frozen, aseptically processed, and nonterminally sterilized costal cartilage segment allografts (CCSAs) are a novel grafting material for such cases that avoid donor-site morbidity, improve operating efficiency, and mitigate the postoperative risks.

Objectives
To report the early experience using fresh frozen, aseptically processed, and nonterminally sterilized CCSAs used in complex primary and secondary rhinoplasties, in Canada.

Methods
We retrospectively reviewed 21 patients (17 female and 4 male patients) who underwent a primary or secondary rhinoplasty surgery using CCSAs from June 2019 to April 2022.

Results
The mean age was 39 years (range, 27-58 years), and the mean body mass index was 23.7 kg/m2 (range, 24-40 kg/m2). Of the 21 procedures, 11 were primary (52.4%) and 10 were secondary (47.6%) rhinoplasties. The mean operative time was 185 min (range, 85-330 min), with a mean follow-up time of 15.0 months (range, 2.0-37.8 months). At follow-up, 19 patients (90.5%) reported being “very satisfied” with their aesthetic results, and only 2 (9.5%) underwent revision surgery. No serious complications were reported, and only 1 case showed evidence of graft resorption.

Conclusions
Based on early experience, this CCSA avoids donor-site morbidity and reduces operative time while maintaining a low complication rate, providing a viable alternative to the use of autologous costal cartilage when indicated in complex primary or secondary rhinoplasties with inadequate native nasal cartilage.

Level of Evidence: 4
Benchmarking cell-type clustering methods for spatially resolved transcriptomics data
Authors: Cheng Andrew , Hu Guanyu , Li Wei Vivian 
Published: November 2022

AbstractSpatially resolved transcriptomics technologies enable the measurement of transcriptome information while retaining the spatial context at the regional, cellular or sub-cellular level. While previous computational methods have relied on gene expression information alone for clustering single-cell populations, more recent methods have begun to leverage spatial location and histology information to improve cell clustering and cell-type identification. In this study, using seven semi-synthetic datasets with real spatial locations, simulated gene expression and histology images as well as ground truth cell-type labels, we evaluate 15 clustering methods based on clustering accuracy, robustness to data variation and input parameters, computational efficiency, and software usability. Our analysis demonstrates that even though incorporating the additional spatial and histology information leads to increased accuracy in some datasets, it does not consistently improve clustering compared with using only gene expression data. Our results indicate that for the clustering of spatial transcriptomics data, there are still opportunities to enhance the overall accuracy and robustness by improving information extraction and feature selection from spatial and histology data.
Multiple errors correction for position-limited DNA sequences with GC balance and no homopolymer for DNA-based data storage
Authors: Li Xiayang , Chen Moxuan , Wu Huaming 
Published: November 2022

Abstract
Deoxyribonucleic acid (DNA) is an attractive medium for long-term digital data storage due to its extremely high storage density, low maintenance cost and longevity. However, during the process of synthesis, amplification and sequencing of DNA sequences with homopolymers of large run-length, three different types of errors, namely, insertion, deletion and substitution errors frequently occur. Meanwhile, DNA sequences with large imbalances between GC and AT content exhibit high dropout rates and are prone to errors. These limitations severely hinder the widespread use of DNA-based data storage. In order to reduce and correct these errors in DNA storage, this paper proposes a novel coding schema called DNA-LC, which converts binary sequences into DNA base sequences that satisfy both the GC balance and run-length constraints. Furthermore, our coding mode is able to detect and correct multiple errors with a higher error correction capability than the other methods targeting single error correction within a single strand. The decoding algorithm has been implemented in practice. Simulation results indicate that our proposed coding scheme can offer outstanding error protection to DNA sequences. The source code is freely accessible at https://github.com/XiayangLi2301/DNA.
GeoWaVe: geometric median clustering with weighted voting for ensemble clustering of cytometry data
Authors: Burton Ross J , Cuff Simone M , Morgan Matt P , Artemiou Andreas , Eberl Matthias 
Published: November 2022

Abstract

Motivation
Clustering is an unsupervised method for identifying structure in unlabelled data. In the context of cytometry, it is typically used to categorize cells into subpopulations of similar phenotypes. However, clustering is greatly dependent on hyperparameters and the data to which it is applied as each algorithm makes different assumptions and generates a different ‘view’ of the dataset. As such, the choice of clustering algorithm can significantly influence results, and there is often not one preferred method but different insights to be obtained from different methods. To overcome these limitations, consensus approaches are needed that directly address the effect of competing algorithms. To the best of our knowledge, consensus clustering algorithms designed specifically for the analysis of cytometry data are lacking.

Results
We present a novel ensemble clustering methodology based on geometric median clustering with weighted voting (GeoWaVe). Compared to graph ensemble clustering methods that have gained popularity in single-cell RNA sequencing analysis, GeoWaVe performed favourably on different sets of high-dimensional mass and flow cytometry data. Our findings provide proof of concept for the power of consensus methods to make the analysis, visualization and interpretation of cytometry data more robust and reproducible. The wide availability of ensemble clustering methods is likely to have a profound impact on our understanding of cellular responses, clinical conditions and therapeutic and diagnostic options.

Availability and implementation
GeoWaVe is available as part of the CytoCluster package https://github.com/burtonrj/CytoCluster and published on the Python Package Index https://pypi.org/project/cytocluster. Benchmarking data described are available from https://doi.org/10.5281/zenodo.7134723.

Supplementary information
Supplementary data are available at Bioinformatics online.
Role of feeding specialization in taste receptor loss: insights from sweet and umami receptor evolution in Carnivora
Authors: Wolsan Mieczyslaw , Sato Jun J 
Published: November 2022

AbstractControversy and misunderstanding surround the role of feeding specialization in taste receptor loss in vertebrates. We refined and tested the hypothesis that this loss is caused by feeding specializations. Specifically, feeding specializations were proposed to trigger time-dependent process of taste receptor loss through deprivation of benefit of using the receptor’s gustatory function. We propose that this process may be accelerated by abiotic environmental conditions or decelerated/stopped because of extragustatory functions of the receptor’s protein(s). As test case we used evolution of the sweet (TAS1R2+TAS1R3) and umami (TAS1R1+TAS1R3) receptors in Carnivora (dogs, cats, and kin). We predicted these receptors’ absence/presence using data on presence/absence of inactivating mutations in these receptors’ genes and data from behavioral sweet/umami preference tests. We identified 20 evolutionary events of sweet (11) or umami (9) receptor loss. These events affected species with feeding specializations predicted to favor sweet/umami receptor loss (27 and 22 species, respectively). All species with feeding habits predicted to favor sweet/umami receptor retention (11 and 24, respectively) were found to retain that receptor. Six species retained the sweet (5) or umami (1) receptor despite feeding specialization predicted to favor loss of that receptor, which can be explained by the time dependence of sweet/umami receptor loss process and the possible decelerating effect of TAS1R extragustatory functions so that the sweet/umami receptor process is ongoing in these species. Our findings support the idea that feeding specialization leads to taste receptor loss and is the main if not only triggering factor for evolutionary loss of taste receptors.
Communication-Aware Energy Consumption Model in Heterogeneous Computing Systems
Authors: Wang Zhuowei , Wang Hao , Song Xiaoyu , Wu JiaHui 
Published: November 2022

Abstract
Large heterogeneous computing systems are composed of conventional central processing units and graphics processing units (GPUs) where communication plays a crucial role for system performance. This paper presents an energy consumption analytical model in terms of communication perception for the communication–computing pipeline characterization of discrete GPUs systems. We propose a dynamically adaptive energy-efficient task assignment approach, which harnesses particle swarm optimization. Static energy optimization is addressed by optimal task partition granularity. The experimental results demonstrate that the communication-based energy optimization algorithms can be more energy-saving than those without communication consideration. For some application benchmarks, the energy consumption can be saved by up to 31%. This implies the potential that the energy-saving optimization methods can be incorporated in system engineering processes.
Addressing Detection Uncertainty inBombus affinis(Hymenoptera: Apidae) Surveys Can Improve Inferences Made From Monitoring
Authors: Otto Clint R V , Schrage Alma C , Bailey Larissa L , Mola John M , Smith Tamara A , Pearse Ian , Simanonok Stacy , Grundel Ralph 
Published: November 2022

AbstractThe U.S. Fish and Wildlife Service developed national guidelines to track species recovery of the endangered rusty patched bumble bee [Bombus affinis Cresson (Hymenoptera: Apidae)] and to investigate changes in species occupancy across space and time. As with other native bee monitoring efforts, managers have specifically acknowledged the need to address species detection uncertainty and determine the sampling effort required to infer species absence within sites. We used single-season, single-species occupancy models fit to field data collected in four states to estimate imperfect detection of B. affinis and to determine the survey effort required to achieve high confidence of species detection. Our analysis revealed a precipitous, seasonal, decline in B. affinis detection probability throughout the July through September sampling window in 2021. We estimated that six, 30-min surveys conducted in early July are required to achieve a 95% cumulative detection probability, whereas &gt;10 surveys would be required in early August to achieve the same level of confidence. Our analysis also showed B. affinis was less likely to be detected during hot and humid days and at patches of reduced habitat quality. Bombus affinis was frequently observed on Monarda fistulosa (Lamiales: Lamiaceae), followed by [Pycnanthemum virginianum Rob. and Fernald (Lamiales: Lamiaceae)], Eutrochium maculatum Lamont (Asterales: Asteraceae), and Veronicastrum virginicum Farw. (Lamiales: Plantaginaceae). Although our research is focused on B. affinis, it is relevant for monitoring other bumble bees of conservation concern, such as B. occidentalis Greene (Hymenoptera: Apidae) and B. terricola Kirby (Hymenoptera: Apidae) for which monitoring efforts have been recently initiated and occupancy is a variable of conservation interest.