bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Web-Based Intervention for Chronic Cancer-Related Fatigue Works Best for Whom? Explorative Moderation Analyses of a Randomized Controlled Trial.
Authors: Schellekens Melanie P. J. , Bruggeman-Everts Fieke Z , Wolvers Marije , Vollenbroek-Hutten Miriam M.R. , Lee Marije L. van der 
Published: February 2022

Abstract
Purpose: Approximately 25% of cancer patients suffers from chronic cancer-related fatigue (CCRF), which is a complex, multifactorial condition. While there are evidence-based interventions, it remains unclear what treatment works best for the individual patient. This study explored whether baseline characteristics moderated the effect of web-based Mindfulness-Based Cognitive Therapy (eMBCT) versus Ambulant Activity Feedback (AAF) and a psycho-education control group (PE) on fatigue in patients suffering from CCRF.Methods: In a randomized controlled trial, participant suffering from CCRF participated in either eMBCT, AAF or PE. Complete data of the treatment-adherent sample (≥6 sessions) was used to explore whether sociodemographic, clinical and psychological characteristics at baseline moderated the intervention effect on fatigue severity at 6 months. Results: A trend suggested that baseline fatigue severity and fatigue catastrophizing moderated the intervention effect. That is, at low levels of fatigue severity and catastrophizing, patients benefited more from AAF than from eMBCT and at high levels of fatigue severity and catastrophizing, patients benefited more from eMBCT than from PE. Conclusions: This study found some preliminary evidence on what treatment works best for the individual suffering from CCRF. These findings suggest a potential gain in effectiveness of personalizing treatment. An alternative and more person-centered approach that might help us further in answering the question ‘what treatment works best for whom?’ is discussed.
Chitosan-silanol groups functional magnetic nanoparticles for heavy metals and bacteria removal
Authors: Liu QiBo , Wang Yonghui , Liu Xueli , Li Shuang , Ren shuyue , Gao Zhixian , Han Tie , Xu Zhangrun , Zhou Huanying 
Published: February 2022

Abstract
Studies have shown that there are multiple co-existence pollutants in environmental water over recent years. In this study, we report the design and synthesis of magnetic adsorbents incorporating chitosan-silanol groups (Fe3O4@Si-OH@CS) with improved physicochemical properties for the removal of various heavy metals and bacteria from polluted water. Fe3O4@Si-OH@CS was synthesised using the co-precipitation method. Scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR), Brunauer-Emmett-Teller (BET), Vibrating sample magnetometer (VSM), and Zeta techniques were used to characterise. The effects of factors such as pH, adsorption time, and adsorbent dosage were optimised. The results indicated that Fe3O4@Si-OH@CS had high adsorption efficiency and adsorption capacity for Cr (VI), As, Hg and Se. Moreover, Cr (VI) and As have a preferential adsorption effect when multiple metal ions coexist. The adsorption performance of Fe3O4@Si-OH@CS to bacteria was verified using E. coli (gram-negative) and S. aureus (gram-positive). The developed adsorbent also showed good adsorption efficiency for both gram-negative and gram-positive bacteria. Overall, the synthesised Fe3O4@Si-OH@CS adsorbent showed high removal efficiency and adsorption capacity with a stable structure and easy separation. It has promising applications for the removal of heavy metals and bacteria from water.
Translating Evidence in a Priority Setting Partnership: Knowledge Gaps Between Healthcare Providers and Oesophageal Cancer Patients
Authors: McDonnell Sarah , Breslin Tara , Elnour Mawaheb , Mascan Bianca , Shahruddin Nur Shuhada , Fanning Michelle , Galvin Anthony , Moore Jennifer , Ravi Narayansamy , Reynolds John V , Donohoe Claire L 
Published: February 2022

Abstract
Despite the fact that medical information is now more accessible than ever, knowledge gaps remain between patients and healthcare providers (HCPs). To date, patients’ need for information following a diagnosis of oesophageal cancer have not been adequately met.Purpose: The purpose of this study was to identify why knowledge gaps exist between oesophageal cancer patients and HCPs and how to address them. Methods: A 7 set question series was developed for use in a patient/HCP focus group in addition to 11 individual phone interviews with survivors of oesophageal cancer. Qualitative semi structured interviews were conducted to explore oesophageal cancer patients’ access to information. The data was analysed thematically, which involved coding all patient transcripts before identifying and reviewing key themes. Results: The three primary themes that emerged were; Opportunity (HCP team factors and relationship development), Ability (Patient factors), and Priority (Pacing of Information Delivery). Conclusion: Effective communication between patients and HCPs was identified as an integral component to the enhancement of patient knowledge. HCP’s should continue to refine and improve methods of information delivery and encourage conversations regarding information preferences. Patients’ must be clearly encouraged to ask questions or raise concerns to ensure continuous access to information. A dedicated representative in place to relay these concerns may prove beneficial. Understanding patient values and the external factors that influence how patients understand their health may allow HCP’s to make evidence-based recommendations in a way that is individualised to the specific needs of the patient.
Nonlinear Control Design for Walking Assistance Training Robotic Systems
Authors: Liu Wei , Wang Shuoyu , Shi Peng 
Published: February 2022

Abstract
In this paper, the control problem for a novel walking assistance training robot is considered where the main objective is utilizing the robot to control the tilt angle and the position of a user. First, the novel walking assistance training robot together with a user is modeled as a nonlinear dynamical system in state space form with control input. Then, based on the nonlinear dynamical system and some results proposed in this paper, a feedback control system is developed, and a nonlinear state feedback control algorithm is designed where the control input includes two parts, namely, a dynamical part and a constant part. By doing this, it is ensured that the feedback control system is stable, and achieves the main objective under some limits for the control input. A simulation example is given to illustrate the effectiveness and performance of the proposed nonlinear state feedback control algorithm.
Children’s Healthy and Unhealthy Food Intake Related to Parental Fear of the Covid-19, Family Communication Patterns, and Parental Controlling Feeding Practices
Authors: Kim Kay W. , Wallander Jan 
Published: February 2022

Abstract
Background: The COVID-19 pandemic has caused abrupt changes in the daily lives of most families, including their food environments. Fear of COVID-19 and family communication patterns are hypothesized to influence parental feeding practices and ultimately children’s intake of healthy as well as unhealthy foods. Based on a conceptual model of direct and indirect effects among these variables, we test these hypotheses in an observational cross-sectional design.Methods: 306 parents (51% fathers) with children in the age range 5 - 12 were recruited via a Facebook snowball sampling method. They completed questionnaires online to measure fear of COVID-19, conversation- and conformity-oriented family communication patterns, and parental controlling feeding practices. In addition, they reported on the child’s intake of food categories marking healthy (fruits and vegetables) and unhealthy (juice, soda, sweets, fast foods) diets. The conceptual model was analyzed with structural equations modeling, including a multi-group analysis to discern differences between mothers and fathers. Results: There were significantly positive associations between parental fear of COVID-19 and both conversation and conformity family communication patterns, both of which in turn were positively associated with parental controlling feeding practices. Conversation communication pattern was associated with reduced unhealthy food intake in children. For the most part, these associations occurred for both mothers and fathers. However, whereas fathers’ communication patterns were not related to children’s food intake, mothers’ conversation pattern was negatively, and conformity pattern was positively, associated with children’s unhealthy food intake.Conclusion: COVID-19 has had a profound impact on families, including children’s dietary intake. These results underscore that general family patterns play an important role for children’s dietary intake. Therefore, it may be useful to help parents adopt general positive parenting approaches to influence their children’s healthy development, including dietary intake.
Multi-omics analysis on seasonal variations of the biofilm microbial community in a full-scale pre-denitrification biofilter
Authors: Tian Lu , Wang Lin , Zhang Xiaofeng , Huang Xuda , Wang Fuhao , Zhu Sifu , Li Xueqiang , Guan Ying 
Published: February 2022

Abstract
The seasonal variations of biofilm communities in a municipal wastewater treatment plant were investigated using multi-omics techniques. The abundance of the main phyla of microorganisms varied with season considerably, the Bacteroidetes enriched in winter and Chloroflexi in summer. The results of metaproteomic and metagenomic showed that most of the functional microorganisms belonged to the Betaproteobacteria class, and the abundance of Flavobacteria class enriched in winter make sure the denitrification performance to some extent. Seasonal variations affected the proteomic expression profiling, a total of 2835 differentially expressed proteins identified were significantly enriched in quorum sensing, two−component system, ribosome, benzoate degradation, butanoate metabolism, citrate cycle (TCA cycle), and cysteine and methionine metabolism pathways. With the expression of nitrogen metabolic proteins decreases in winter, the overall expression of denitrification-related enzymes in winter was much lower than that in summer, the nitrogen metabolism pathway varied significantly. Seasonal variations also induced the alteration of the biofilm metabolite profile; a total of 66 differential metabolites, 8 potential biomarkers, and 8 perturbed metabolic pathways such as TCA cycle were detected. It was found that most of the perturbed pathways are directly related to nitrogen metabolism, and several amino acids and organic acids associated with the TCA cycle were significantly perturbed, the accumulation of TCA cycle intermediates, ornithine and L-histidine in winter might be conducive to resisting cold temperatures. Furthermore, the correlation between biofilm microbial communities and metabolites was identified by the combined analysis of metabolomic and metaproteomic. The differences of microbial community structure, function and metabolism between winter and summer in a full-scale pre-denitrification biofilter were revealed for the first time, strengthening our understanding of the microbial ecology of biofilm communities.
Crowberry Inhibits Cell Proliferation and Migration Through a Molecular Mechanism that Includes Inhibition of DEK and Akt Signaling in Cholangiocarcinoma
Authors: Wang Xue , Zhang Ludan , Zhang Xin , Zhou Xuebing , Yang Chunyu , Piao Yingshi , Zhao Jinhua , Jin Lili , Jin Guihua , An Renbo , ren xiangshan 
Published: February 2022

Abstract
Background: Cholangiocarcinoma (CCA) is a rare biliary adenocarcinoma related to poor clinical prognosis. Crowberry is an herbal medicine used to control inflammatory diseases and reestablish antioxidant enzyme activity. Although crowberry shows significant therapeutic efficacy in various tumors and diseases, its anticancer effects and specific molecular mechanisms in CCA are poorly understood. Aim of the study: This study was conducted to characterize crowberry effects on CCA cells behavior.Materials and methods: The chemical profiles of crowberry extract was qualitatively analyzed by high-performance liquid chromatography (HPLC) and HPLC--tandem mass spectrometry. MTT, colony formation and EdU assays were performed to measure cell proliferation. The effect of crowberry treatment on CCA cell migration was assessed by wound healing and migration assays. Moreover, Hoechst staining assay and flow cytometry were performed to assess the cell apoptosis rate. Western blotting was used to assess the protein expression levels of key factors associated with apoptosis, the Akt signaling pathway, and the epithelial-mesenchymal transition. A xenograft model was established and immunohistochemical and H&E staining was performed to assess crowberry antitumor effects in vivo.Results: Crowberry clearly inhibited CCA cells proliferation and migration in a dose-dependent manner and induced apoptosis in vitro. Crowberry inactivated the PI3K/Akt signaling pathway by regulating DEK in vitro and significantly inhibited tumor growth by downregulating the DEK expression in xenograft models. Conclusion: Crowberry inhibits CCA cells proliferation and migration through a molecular mechanism that includes inhibition of DEK and Akt signaling pathway inhibition in vitro and in vivo.
Cardiac MRI Segmentation Using Deep Learning
Authors: Das Niharika , Das Sujoy 
Published: February 2022

Abstract
Cardiovascular diseases (CVDs) remain the principal cause of all global death and disabilities worldwide. Cardiac MR Images play an important role in diagnosing and treating cardiac ailments in patients. Automatic segmentation of Cardiac Magnetic Resonance Imaging (Cardiac MRI) is an essential application in clinical practice. In this paper, Cardiac MRI segmentation is performed using a convolutional neural network. ACDC Challenge 2017 dataset is used the training and testing purpose. It consists of data of 100 subjects, including the End Systole and End Diastole phase. The model's performance is measured using the Dice coefficient, achieving an accuracy of 0.90. The results for basal as well as with apical slices are pretty encouraging.
Evidence for Anti-inflammatory Effects and Modulation of Neurotransmitter Metabolism by Salvia Officinalis L.
Authors: Margetts Gemma , Kleidonas Sotirios , Zaibi Nawel S. , Zaibi Mohamed S. , Edwards Kieron D. 
Published: February 2022

Abstract
Background: Cognitive health is of great interest to society, with neuroinflammation and systemic inflammation as age-related risk factors linked to declines in cognitive performance. Several botanical ingredients have been suggested to have benefits in this area including sage (Salvia officinalis), which has shown anti-inflammatory effects and exhibited promising cognitive improvements in multiple human studies. The current study aims to further investigate sage’s anti-inflammatory effects in human cells and uncover other relevant biological activities.Methods: The release of multiple Cytokine and Chemokines was measured in human primary intestinal epithelial cells treated with sage extract, with or without LPS stimulation, and Blood Brain Barrier (BBB) cells in presence or absence of recombinant IL-17A and/or Human IL-17RA/IL-17R Antibody. Antioxidant effects were also assessed in BBB cells incubated with the extract and H2O2. The anti-inflammatory effects of sage extract were further assessed based on clinically-relevant biomarker readouts across twelve human primary cell-based disease models of the BioMAP® Diversity PLUS® Panel. Results: Sage showed significant attenuation of the release of most cytokines/chemokines into apical media in LPS-stimulated intestinal cells, but small increases of in the release of markers including IL-6, IL-8 in basolateral media; where TNF-α was the only marker to be significantly reduced. Sage attenuated the release of CRP and VCAM-1 from BBB cells under IL-17A induced conditions, as well as the basal level of release of MCP-1, and also decreased H2O2 induced ROS overproduction in these cells. Phenotypic profiling with the BioMAP® Diversity PLUS® Panel identified additional anti-inflammatory mediators, and based on a similarity search analysis suggested potential mechanistic similarity to caffeic acid and drugs known to inhibit COMT and MAO activity to modulate monoamine metabolism. Subsequent in vitro assessment showed that sage was able to inhibit the activity of these same enzymes. Conclusions: Sage extract showed anti-inflammatory effects across multiple human cell lines, which could potentially reduce peripheral inflammation and support cognitive health. Sage extract also showed the ability to inhibit enzymes related to the metabolism of monoamine neurotransmitters, suggesting possible dopaminergic and serotonergic effects acting alongside proposed cholinergic effects to mediate acute cognitive performance benefits previously demonstrated for the extract.
A Single-Arm Clinical Study Assessing Safety and Effectiveness of Path Removal for Delayed Patch Infection After Inguinal Hernioplasty
Authors: yue yumin , Cai Xiangreng , guo xin , Chen Xi , Zheng Bobo 
Published: February 2022

Abstract
Introduction: Patch infection after inguinal hernioplasty as an annoyance perplexed surgeon, Because its processing is very tricky. When conservative treatment fails, the surgical that played a pivotal role in the future therapies. Our target was to evaluate the safety and effectiveness of path removal for delayed patch infection after inguinal hernioplasty and give a summary of our experience in surgical treatment.Methods: A retrospective cross-sectional study was undertaken at the Department of General Surgery from March 2018 to May 2021 to gather the clinical data of 35 patients with delayed cloth patch infection following tension-free hernioplasty. Record clinical information about the patient which included patient age, underlying disease, primary hernia repair, meantime of infection diagnosis, patient clinical symptoms, the intraoperative complications included the relevant postoperative conditions, the placement and time of drainage tubes, the postoperative hospital stay, the bacterial culture results of patch infection, and the choice and use of antibiotics.The follow-up included postoperative reinfection and long-term complications. Patients or their families were contacted by telephone to understand their postoperative recovery as well as any long-term complications. Results: All patients have undergone laparoscopic or open surgical operation were smooth and steady. All patients with postoperative infection after tension-free repair of inguinal Hernia received patch removal, all of them were treated with antibiotics, open wound drainage or negative pressure drainage, 2 cases had a perforation of a sigmoid foreign body. The mean postoperative hospital stay was (23.74±15.91) days. A total of 35 patients with patch infection were followed up postoperatively During the follow-up period, no postoperative complications occurred. There was no recurrence of inguinal hernia during postoperative follow-up. Conclusion: When dealing with patch infection after tension-free repair of an inguinal hernia, it is safe and efficacious to perform patch extraction.
Role of Soluble Triggering Receptors Expressed on Myeloid Cells -1 and 25-Hydroxy Vitamin D as Early Predictors of Neonatal Ventilator Associated Pneumonia
Authors: El-Sheikh Mai Rabie , Elmahdy Heba Said , Nassar Mohammed Abd Ellatif , Fouda Mohamed Hosni , ibrahim Ashraf 
Published: February 2022

Abstract
Ventilator associated pneumonia (VAP) is considered one of the most nosocomial pneumoniae in ventilated neonates. Yet, its diagnosis is very difficult due to non-specific clinical parameters and the lack of sensitive biomarker. The main objective of this study was to assess comparison between soluble triggering receptors expressed on myeloid cells -1 (sTREM-1) and 25-hydroxy vitamin D as early predictors of neonatal VAP. This prospective cohort study included 85 ventilated neonates who were divided into two groups; VAP group (n = 33) and non-VAP group (n = 52). sTREM-1 level in the endotracheal aspirate (ETA) and serum 25-Hydroxy vitamin D were measured on the third and seventh days following mechanical ventilation. sTREM-1 cutoff value of > 0.46 and > 0.44 ng/ml at 3 and 7 days had a sensitivity of 93.94% and 96.97%, a specificity of 92.31% and 100%, and area under the receiver operating characteristic curve (AUC) of 0.963 and 0.993 respectively to predict the development of neonatal VAP. A cutoff value of ≤17.5 ng/ml for serum 25-Hydroxy vitamin D at 3 and 7 days had a sensitivity of 90.91% and 81.82%, a specificity of 75% and 78.85%, and AUC of 0.877 and 0.939 respectively.Conclusion: Both sTREM-1 in ETA and serum 25-Hydroxy vitamin D could be used as early predictors of neonatal VAP, but sTREM-1 appears to be more useful.
Psychogenic Fever and Postural Tachycardia Syndrome Among School-aged Children and Adolescents With Fever of Unknown Origin
Authors: Ishizaki Yuko , Yanagimoto Yoshitoki , Fujii Yuri , Yamamoto Mana , Kaneko Kazunari 
Published: February 2022

Abstract
Background: Although fever is a common symptom in pediatric practice, its origin is often unknown in pediatric patients. Psychogenic fever is a stress-related, psychosomatic disease observed especially in young women. This study aimed to estimate the prevalence of psychogenic fever in pediatric patients with fever of unknown origin by surveying the medical records of school-aged children and adolescents.Methods: The study subjects included 47 patients aged 6–15 years who visited the Department of Pediatrics in Kansai Medical University Medical Center between January 2006 and December 2020 with fever of unknown origin. Data on age, sex, final estimated diagnosis, and comorbid psychosocial issues were collected from the medical records. Results: The study subjects was composed of 47 patients, including 22 male and 25 female patients (male/female ratio, 1:1.36). The mean age was 10.1 (standard deviation, 2.4) years in boys and 11.6 (standard deviation, 2.7) years in girls (p = .047). The final estimated diagnoses were psychogenic fever, physical disorder, infection of unknown origin, and miscellaneous in 18, 12, 12, and 5 patients, respectively. The most common comorbidity in pediatric patients with psychogenic fever was postural tachycardia syndrome. Conclusion: Psychogenic fever was a common cause in pediatric patients with fever of unknown origin, and postural tachycardia was prevalent among children with psychogenic fever. Enhanced sympathetic response to stress might play an important role in both psychogenic fever and postural tachycardia.