bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delay-on-Squash: Stopping Microarchitectural Replay Attacks in Their Tracks
Authors: Sakalis Christos , Kaxiras Stefanos , Själander Magnus 
Published: September 2022

MicroScope and other similar microarchitectural replay attacks take advantage of the characteristics of speculative execution to trap the execution of the victim application in a loop, enabling the attacker to amplify a side-channel attack by executing it indefinitely. Due to the nature of the replay, it can be used to effectively attack software that are shielded against replay, even under conditions where a side-channel attack would not be possible (e.g., in secure enclaves). At the same time, unlike speculative side-channel attacks, microarchitectural replay attacks can be used to amplify the correct path of execution, rendering many existing speculative side-channel defenses ineffective.
In this work, we generalize microarchitectural replay attacks beyond MicroScope and present an efficient defense against them. We make the observation that such attacks rely on repeated squashes of so-called “replay handles” and that the instructions causing the side-channel must reside in the same reorder buffer window as the handles. We propose Delay-on-Squash, a hardware-only technique for tracking squashed instructions and preventing them from being replayed by speculative replay handles. Our evaluation shows that it is possible to achieve full security against microarchitectural replay attacks with very modest hardware requirements while still maintaining 97% of the insecure baseline performance.
Mineral and Phenolic Composition of Erodium guttatum Extracts and Investigation of Their Antioxidant Properties in Diabetic Mice
Authors: Benrahou Kaoutar , Mrabti Hanae Naceiri , Fettach Saad , Kachmar Mohamed Reda , Kouach Mostafa , Goossens Jean-François , Doudach Latifa , Mahmud Shafi , Alshahrani Mohammed Merae , Al Awadh Ahmed Abdullah , Bouyahya Abdelhakim , Faouzi My El Abbes 
Published: September 2022

Erodium guttatum is widely used in folk medicine in many countries to treat various ailments such as urinary inflammation, diabetes, constipation, and eczema. The aim of this study is the determination of mineral and phenolic compounds of E. guttatum extracts as well as the investigation of their antidiabetic and antioxidant properties. The mineral composition was determined by the methods of inductively coupled plasma atomic emission spectroscopy analysis. Phytochemical contents of total polyphenols, total flavonoids, and catechic tannins were estimated by colorimetric dosages. The phenolic composition was identified by high-resolution mass spectrometry (HRMS) analysis. The antioxidant activity of E. guttatum extracts was measured in vitro by five methods (DPPH, ABTS, FRAP, H2O2, and xanthine oxidase) and in vivo by assaying the malondialdehyde marker (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). The obtained results showed that the root plant material is rich in minerals such as k, Ca, and Mg. The methanolic extract of E. guttatum is the richest in polyphenols (

389.20
±
1.55

mg

EAG/gE), tannins (

289.70
±
3.57

mg

EC/gE), and flavonoids (

432.5
±
3.21

mg

ER/gE). Concerning the ESI-HRMS analysis, it showed the presence of numerous bioactive compounds, including shikimic acid, rottlerine, gallic acid, and vanillic acid. Moreover, the aqueous and alcoholic extracts of E. guttatum exhibited antiradical and antioxidant activity in five tests used, with the best effect of the methanolic extract. Moreover, findings showed that in vivo investigations confirmed those obtained in vitro. On the other hand, E. guttatum showed important antidiabetic effects in vivo. Indeed, diabetic mice treated with extracts of E. guttatum were able to significantly reduce MDA levels and increase the secretion of enzymatic and nonenzymatic antioxidants (SOD, CAT, and GSH, respectively). However, the antioxidant activity of the extracts might be attributed to the abundance of bioactive molecules; as results, this work serves as a foundation for additional pharmacological research.
Digital Future of Emergency Medical Services: Envisioning and Usability of Electronic Patient Care Report System
Authors: Al Haliq Samer , Al Jumaan Mohammed 
Published: September 2022

Despite the efforts of emerging technologies in the healthcare system, there is still a slower rate of acceleration in prehospital settings compared with the hospitals in digital transformation adaptation. The acknowledgment that digital transformation is significant to healthcare is reflected in planning for the future of digital healthcare. Thus, this study aimed to measure the usability of the electronic patient care report (ePCR) system among emergency medical services (EMS) staff who work in prehospital settings. A descriptive cross-sectional correlation study was used. Two hundred fifty EMS staff who are working in the prehospital setting at Saudi Red Crescent Authority in the Kingdom of Saudi Arabia were surveyed, and the response rate was 79.2% (198). An adapted tool of the Computer System Usability Questionnaire survey was used to collect data. The data were coded numerically and subjected to descriptive and inferential statistical analysis including Pearson’s correlation coefficient using the statistical software (SPSS 21). The majority of the participants rate their ePCR system as “useable” at a high level with a score of 3.41 (SD = 1.021). The overall mean of the ePCR system’s three subscales: system usefulness, information quality, interface quality, and overall satisfaction were 3.39 (SD = 1.152), 3.30 (SD = 1.052), 3.57 (SD = 1.064), and 3.37 (SD = 1.239), respectively. The least liked aspect of ePCR system software was information quality 81 (40.9%). Furthermore, there was a significant correlation between the age of EMS staff and the usability of the ePCR system (r = −0.150

∗

,

P
=
0.035

). The results suggest that healthcare institutions’ policy and decision-makers pay close attention to performing standardized training for the staff on their ePCR system before going to the field to increase efficiency and productivity. Furthermore, the users in this study identified other system features that, if included, could have enhanced usability, and improved functions and capabilities of the design to meet the EMS staff’s expectations.
Natural Coevolution of Tumor and Immunoenvironment in Glioblastoma
Authors: Wu Lingxiang , Wu Wei , Zhang Junxia , Zhao Zheng , Li Liangyu , Zhu Mengyan , Wu Min , Wu Fan , Zhou Fengqi , Du Yuxin , Chai Rui-Chao , Zhang Wei , Qiu Xiaoguang , Liu Quanzhong , Wang Ziyu , Li Jie , Li Kening , Chen Apeng , Jiang Yinan , Xiao Xiangwei , Zou Han , Srivastava Rashmi , Zhang Tingting , Cai Yun , Liang Yuan , Huang Bin , Zhang Ruohan , Lin Fan , Hu Lang , Wang Xiuxing , Qian Xu , Lv Sali , Hu Baoli , Zheng Siyuan , Hu Zhibin , Shen Hongbing , You Yongping , Verhaak Roel G.W. , Jiang Tao , Wang Qianghu 
Published: September 2022

Abstract

Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) has a dismal prognosis. A better understanding of tumor evolution holds the key to developing more effective treatment. Here we study GBM's natural evolutionary trajectory by using rare multifocal samples. We sequenced 61,062 single cells from eight multifocal IDH wild-type primary GBMs and defined a natural evolution signature (NES) of the tumor. We show that the NES significantly associates with the activation of transcription factors that regulate brain development, including MYBL2 and FOSL2. Hypoxia is involved in inducing NES transition potentially via activation of the HIF1A–FOSL2 axis. High-NES tumor cells could recruit and polarize bone marrow–derived macrophages through activation of the FOSL2–ANXA1–FPR1/3 axis. These polarized macrophages can efficiently suppress T-cell activity and accelerate NES transition in tumor cells. Moreover, the polarized macrophages could upregulate CCL2 to induce tumor cell migration.

Significance:
GBM progression could be induced by hypoxia via the HIF1A–FOSL2 axis. Tumor-derived ANXA1 is associated with recruitment and polarization of bone marrow–derived macrophages to suppress the immunoenvironment. The polarized macrophages promote tumor cell NES transition and migration.
This article is highlighted in the In This Issue feature, p. 2711
Second Language Immersion Experience Could Help the Brain Response to Second Language Reading for Native Chinese Speakers
Authors: Wang Cuicui , Flemming Krystal , Yang Zhen , Cortiana Giulia , Lammert Jessica , Rafat Yasaman , Tao Sha , Joanisse Marc F. 
Published: September 2022

Abstract
Native language background exerts constraints on the individual's brain automatic response while learning a second language. It remains unclear, however, whether second language immersion experience could help the brain overcome such constraints and meet the requirements of a second language. This study compared native Chinese speakers with English-as-a-second-language immersion experience (immersive English learners), native Chinese speakers without English-as-a-second-language immersion experience (nonimmersive English learners), and native English speakers with an ERP cross-modal MMN paradigm. The results found that English-as-a-second-language immersion could benefit speech perception for native Chinese speakers. In addition, both immersive English learners and native English speakers showed enhanced cross-modal MMN, indicating that second language immersion could help native Chinese speakers successfully integrate English letter–sound like native English speakers. The present study further revealed that English listening and speaking exposure in an immersive environment is important in English letter–sound integration for immersive English learners.
A Critical Test of Deep Convolutional Neural Networks' Ability to Capture Recurrent Processing in the Brain Using Visual Masking
Authors: Loke Jessica , Seijdel Noor , Snoek Lukas , van der Meer Matthew , van de Klundert Ron , Quispel Eva , Cappaert Natalie , Scholte H. Steven 
Published: September 2022

Abstract
Recurrent processing is a crucial feature in human visual processing supporting perceptual grouping, figure-ground segmentation, and recognition under challenging conditions. There is a clear need to incorporate recurrent processing in deep convolutional neural networks, but the computations underlying recurrent processing remain unclear. In this article, we tested a form of recurrence in deep residual networks (ResNets) to capture recurrent processing signals in the human brain. Although ResNets are feedforward networks, they approximate an excitatory additive form of recurrence. Essentially, this form of recurrence consists of repeating excitatory activations in response to a static stimulus. Here, we used ResNets of varying depths (reflecting varying levels of recurrent processing) to explain EEG activity within a visual masking paradigm. Sixty-two humans and 50 artificial agents (10 ResNet models of depths −4, 6, 10, 18, and 34) completed an object categorization task. We show that deeper networks explained more variance in brain activity compared with shallower networks. Furthermore, all ResNets captured differences in brain activity between unmasked and masked trials, with differences starting at ∼98 msec (from stimulus onset). These early differences indicated that EEG activity reflected “pure” feedforward signals only briefly (up to ∼98 msec). After ∼98 msec, deeper networks showed a significant increase in explained variance, which peaks at ∼200 msec, but only within unmasked trials, not masked trials. In summary, we provided clear evidence that excitatory additive recurrent processing in ResNets captures some of the recurrent processing in humans.
The Angular Gyrus as a Hub for Modulation of Language-related Cortex by Distinct Prefrontal Executive Control Regions
Authors: Kim Hyojeong , Wang Kai , Cutting Laurie E. , Willcutt Erik G. , Petrill Stephen A. , Leopold Daniel R. , Reineberg Andrew E. , Thompson Lee A. , Banich Marie T. 
Published: September 2022

Abstract
It has become clear in recent years that reading, while relying on domain-specific language processing regions, also involves regions that implement executive processes more broadly. Such executive control is generally considered to be implemented by prefrontal regions, which exert control via connectivity that allows them to modulate processing in target brain regions. The present study examined whether three previously identified and distinct executive control regions in the pFC [Wang, K., Banich, M. T., Reineberg, A. E., Leopold, D. R., Willcutt, E. G., Cutting, L. E., et al. Left posterior prefrontal regions support domain-general executive processes needed for both reading and math. Journal of Neuropsychology, 14, 467–495, 2020] show similar patterns of functional connectivity (FC) during a reading comprehension task as compared with a symbol identification condition. Our FC results in a sample of adolescents (n = 120) suggest all three regions commonly show associations with activity in “classic” left hemisphere reading areas, including the angular and supramarginal gyri, yet each exhibits differential connectivity as well. In particular, precentral regions show differential FC to parietal portions of the dorsal language stream, the inferior frontal junction shows differential FC to middle temporal regions of the right hemisphere and other regions involved in semantic processing, and portions of the inferior frontal gyrus show differential FC to an extensive set of right hemisphere prefrontal regions. These results suggest that prefrontal control over language-related regions occurs in a coordinated yet discrete manner.
Graph theoretical approach to brain remodeling in multiple sclerosis
Authors: Abdolalizadeh AmirHussein , Ohadi Mohammad Amin Dabbagh , Ershadi Amir Sasan Bayani , Aarabi Mohammad Hadi 
Published: September 2022

Abstract
Multiple sclerosis (MS) is a neuroinflammatory disorder damaging structural connectivity. Natural remodeling processes of the nervous system can, to some extent, restore the damage caused. However, there is a lack of biomarkers to evaluate remodeling in MS. Our objective is to evaluate graph theory metrics (especially modularity) as a biomarker of remodeling and cognition in MS. We recruited 60 relapsing-remitting MS and 26 healthy controls. Structural and diffusion MRI, plus cognitive and disability evaluations, were done. We calculated modularity and global efficiency from the tractography-derived connectivity matrices. Association of graph metrics with T2 lesion load, cognition, and disability was evaluated using general linear models adjusting for age, gender, and disease duration wherever applicable. We showed that MS subjects had higher modularity and lower global efficiency compared with controls. In the MS group, modularity was inversely associated with cognitive performance but positively associated with T2 lesion load. Our results indicate that modularity increase is due to the disruption of intermodular connections in MS because of the lesions, with no improvement or preserving of cognitive functions.
The Northern Australia Climate Program: Overview and Selected Highlights
Authors: Lavender Sally L. , Cowan Tim , Hawcroft Matthew , Wheeler Matthew C. , Jarvis Chelsea , Cobon David , Nguyen Hanh , Hudson Debra , Sharmila S. , Marshall Andrew G. , de Burgh-Day Catherine , Milton Sean , Stirling Alison , Alves Oscar , Hendon Harry H. 
Published: September 2022

Abstract
Since 2017, the Northern Australia Climate Program (NACP) has assisted the pastoral grazing industry to better manage drought risk and climate variability. The NACP funding is sourced from the beef cattle industry, government, and academia, representing the program’s broad range of aims and target beneficiaries. The program funds scientists in the United Kingdom and Australia, in addition to extension advisers called “Climate Mates” across a region that supports 15 million head of cattle. Many Climate Mates are employed in the cattle sector and have existing relationships in their communities and capacity to meaningfully engage with the program’s intended beneficiaries—red meat producers. The NACP is a prime example of a successful end-to-end program, integrating climate model improvements (research) with tailored forecast products (development), through to direct stakeholder engagement (extension), on-ground application of technologies (adoption), and improvement in industry and community resilience (impact). The climate information needs of stakeholders also feed back to the research and development components, ensuring the scientific research directly addresses end-user requirements. For any scientific research program, ensuring that research output has measurable real-world impact represents a key challenge. This is more difficult in cases where the scientific research is several steps away from the customer’s needs. This paper gives an overview of the NACP and research highlights, discussing how the end-to-end framework could be adapted and applied in other regions and industries. It seeks to provide a roadmap for other groups to follow to produce more targeted research with identifiable real-world benefits.
Low-Level Circulation and Its Coupling with Free-Tropospheric Variability as a Mechanism of Spontaneous Aggregation of Moist Convection
Authors: Yanase Tomoro , Nishizawa Seiya , Miura Hiroaki , Takemi Tetsuya , Tomita Hirofumi 
Published: September 2022

Abstract
The organization of clouds has been widely studied by numerical modeling as an essential problem in climate science. Convective self-aggregation (CSA) occurs in radiative–convective equilibrium when the model domain size is sufficiently large. However, we have not yet reached a comprehensive understanding of the mechanism of CSA onset. This study argues that low-level circulation is responsible for horizontal moisture transport and that its coupling with variabilities of diabatic heating and moisture in the free troposphere is essential. We simulated scattered and aggregated convection by varying the domain size as a control parameter constraining the horizontal scale associated with the CSA onset. Based on a new analysis method quantifying the circulation spanning dry and moist regions, we found that 1) the upgradient moisture transport in the aggregated cases is associated with low-level circulation development, amplifying the horizontal moisture contrast; 2) the horizontal buoyancy gradient due to strong radiative cooling in the dry region intensifies the low-level circulation; 3) the free-tropospheric subsidence intrudes into the boundary layer in the dry region preceding the intensification of low-level circulation; and 4) the subsidence intrusion is due to a weakening of convective heating in the free troposphere associated with the moisture variability at a larger horizontal scale. This study provides new insights into the organization mechanism of clouds unifying the different mechanisms impacting CSA: the free-tropospheric moisture, radiation, convection, and low-level circulation.
Multiple Equilibria in a Coupled Climate–Carbon Model
Authors: Zhu Fangze , Rose Brian E. J. 
Published: September 2022

Abstract
Multiple stable equilibria are intrinsic to many complex dynamical systems, and have been identified in a hierarchy of climate models. Motivated by the idea that the Quaternary glacial–interglacial cycles could have resulted from orbitally forced transitions between multiple stable states mediated by internal feedbacks, this study investigates the existence and mechanisms of multiple equilibria in an idealized, energy-conserving atmosphere–ocean–sea ice general circulation model with a fully coupled carbon cycle. Four stable climates are found for identical insolation and global carbon inventory: an ice-free Warm climate, two intermediate climates (Cold and Waterbelt), and a fully ice-covered Snowball climate. A fifth state, a small ice cap state between Warm and Cold, is found to be barely unstable. Using custom radiative kernels and a thorough sampling of the model’s internal variability, three equilibria are investigated through the state dependence of radiative feedback processes. For fast feedbacks, the systematic decrease in surface albedo feedback from Cold to Warm states is offset by a similar increase in longwave water vapor feedback. At longer time scales, the key role of the carbon cycle is a dramatic lengthening of the adjustment time comparable to orbital forcings near the Warm state. The dynamics of the coupled climate–carbon system are thus not well separated in time from orbital forcings, raising interesting possibilities for nonlinear triggers for large climate changes.

Significance Statement
How do carbon cycle and other physical processes affect the physical and mathematical properties of the climate system? We use a complex climate model coupled with a carbon cycle to simulate the climate evolution under different initial conditions. Four stable climate states are possible, from the Snowball Earth, in which ice covers the whole planet, to the Warm state, an ice-free world. The carbon cycle drives the global climate change at an extremely slower pace after sea ice retreats. Sea ice and water vapor, on the other hand, constitute the major contributing factors that accelerate faster climate change.
Eradicating extreme poverty in Africa through productive inclusion: A comparative assessment of two social protection programmes in Ghana
Authors: Amofa Seth Kwakye , Owusu Godfred Matthew Yaw , Bawole Justice Nyigmah , Atta Moses 
Published: September 2022

Ghana has experimented with two social protection programmes: the Livelihood Empowerment Against Poverty (LEAP) programme, and the Japan Social Development Fund (JSDF) pilot project aimed at reducing extreme poverty and enhancing the standard of living of beneficiaries. This study comparatively assessed how the LEAP programme and the JSDF-LEAP project have contributed to improving the standard of living of beneficiaries. A sample of 167 respondents, comprising 81 LEAP households, 82 JSDF-LEAP beneficiaries and four District Social Welfare Officers took part in the study. The study findings suggest that cash transfers alone such as the LEAP programme may not yield significant improvement in the standard of living of the extremely poor without complementary programmes such as the JSDF-LEAP project to address the livelihood and other socio-economic challenges that they encounter. The study recommends a holistic approach to tackling extreme poverty through ‘cash plus’ programmes. Points for practitioners The findings of this study highlight the need for public administration practitioners involved in poverty eradication programmes to pursue a simultaneous design involving the implementation of both cash transfers and productive inclusion programmes as the preferred strategy for improving the standard of living of the extremely poor. Moreover, this research has also revealed that for social protection programmes to be successfully implemented, carefully designed systems and structures must be put in place at the national level, through the regional, district and community levels at the design and implementation phases of such interventions.