bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychiatric clinical profiles and pharmacological interactions in COVID-19 inpatients referred to a consultation liaison psychiatry unit
Authors: Arbelo N. , Sagué M. , López-Pelayo H. , Madero S. , Pinzón-Espinosa J. , Anmella G. , Gomes-Da-Costa S. , Ilzarbe L. , Llach C. , Cámara M. , Imaz M.L. , Pintor L. 
Published: February 2022

IntroductionThe Coronavirus Disease 2019 (COVID-19) can affect mental health in different ways. There is little research about psychiatric complications in hospitalized patients with COVID-19.ObjectivesThe aim of the study was to describe the psychiatric clinical profile and pharmacological interactions in COVID-19 inpatients referred to a Consultation-Liaison Psychiatry (CLP) unit.MethodsThis is a cross-sectional retrospective study, carried out at a tertiary hospital in Spain, in inpatients admitted because of COVID-19 and referred to our CLP Unit from March 17,2020 to April 28,2020. Clinical data were extracted from electronic medical records. The patients were divided in three groups depending on psychiatric diagnosis: delirium, severe mental illness (SMI) and non-severe mental illness (NSMI).ResultsOf 71 patients included (median [ICR] age 64 [54-73] years; 70.4% male), 35.2% had a delirium, 18.3% had a SMI, and 46.5% had a NSMI. Compared to patients with delirium and NSMI, patients with SMI were younger, more likely to be institutionalized and were administered less anti-COVID19 drugs. Mortality was higher among patients with delirium (21.7%) than those with SMI (0%) or NSMI (9.45%). The rate of side effects due to interactions between anti-COVID19 and psychiatric drugs was low, mainly drowsiness (4.3%) and borderline QTc prolongation (1.5%).ConclusionsPatients affected by SMI were more often undertreated for COVID-19. However, the rate of interactions was very low, and avoidable with a proper evaluation and drug-dose adjustment. Half of the patients with SMI were institutionalized, suggesting that living conditions in residential facilities could make them more vulnerable to infection.DisclosureNo significant relationships.
Evaluation of anxiety symptoms and depression in the general albanian population during quarantine
Authors: Elezi F. , Tomori S. , Tafani G. 
Published: February 2022

IntroductionDuring the COVID-19 pandemic, the Albanian authorities declared mandatory stay-at-home measures, closing businesses, schools and public places.ObjectivesTo investigate the impact of these immediate changes on the mental wellbeing of the population.MethodsRespondents (N=1678) from 18 to 60 years old were selected through a convenient sampling method. Questionnaires were administered online reporting time spent daily in the COVID-19 topic and genealities; the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7.ResultsFindings suggest a significant negative correlation between age and anxiety scoring (r(n=1678)=-.121, p≤.001) and age and depression scoring (r(n=1678)=-.232, p≤.001), shown also on the ANOVA test for age and anxiety (F=6.019, p≤.05) and age and depression (F=20.326, p≤.05). Differences on the level of education resulted in a lower score of anxiety and depression respectively (F=3.524, p≤.05), (F=7.739, p≤.05) on respondents with higher education. Those who were jobless from the pandemic scored higher on anxiety and depression respectively (F=9.760, p≤.05) (M=6.21, ds=4.686) and (F=16.051, p≤.05) (M=8.18, ds=5.791). Significant differences were found related to different amounts of time spent on the COVID-19 topic, respectively for anxiety and depression (F=25.736, p≤.001), (F=5.936, p≤.003), with people who spend less than 1 hour scoring higher on depression (M=7.57, ds= 5.849) and those who spend more than 3 hours scoring higher on anxiety (M=6.76, ds=5.60).ConclusionsHigher education individuals, having a job and being in a romantic relationship relate to lower levels of depression during Covid-19 quarantine in Albania. Spending more time on the COVID-19 topic daily and being a female relate to higher level of anxiety.DisclosureNo significant relationships.
Clinical profile of patients admitted in an acute psychiatric ward before and during the COVID-19 lockdown
Authors: Palomo A. Giménez , Baldaquí N. , Colomer L. , Gutiérrez F. , Pujal E. , Barrio P. , Bioque M. , Vieta E. , Pacchiarotti I. 
Published: February 2022

IntroductionThe COVID-19 pandemic entailed several changes in health and medical assistance, economy, and lifestyle. In the Acute Psychiatric Ward of the Hospital Clínic of Barcelona, the implementation of restrictive measures was necessary in order to ensure patients’ safety.ObjectivesTo compare clinical profiles and course of hospitalization of patients admitted before and during the COVID-19 lockdown in our Acute Psychiatric Ward.MethodsAll patients admitted from January 7th to February 25th and from March 19th to May 7th of 2020 in the Acute Psychiatric Hospitalization Unit of Hospital Clínic of Barcelona, Spain, were retrospectively included for analysis and divided into two groups according to the period when they were admitted. Statistical analyses were performed using SPSS, 23.0 version.ResultsA total of 117 inpatients were included (73 admitted before lockdown and 44 during lockdown), being 50.4% male, with a mean age of 42.4 (SD 15.73). Patients from the first group presented a significantly higher proportion of antidepressants prescription at discharge (p<0.05) and more substance use disorders (p<0.05). Regarding the lockdown group, 51% of patients manifested COVID-19-related stress. Time of hospitalization was significantly lower in the lockdown group (p<0.05), even though a significantly higher proportion of patients were discharged at home (p<0.05) compared with the first group.ConclusionsThe situation of lockdown led to a series of changes in our unit and also in the profile of patients admitted, having shorter admissions, lower prescription of antidepressants, and often COVID-related stress. These differences should be considered in future situations in which restrictive measures may be necessary.DisclosureNo significant relationships.
The perception of individuals in society about protection measures from COVID-19 infection: The example of turkey
Authors: Oflaz F. , Atkan F. 
Published: February 2022

IntroductionThe course of the epidemics such as COVI9 -19 and SARS has taught us that the management of the epidemic depends primarily on people’s adherence to and implementation of the recommended measures.ObjectivesThis study aimed to determine the knowledge and opinions of individuals about COVID-19 and transmission methods, sources of information, application status about protection measures and related factors.Methods1444 people participated into the digital survey between March 22-April 6, 2020 for this descriptive study. For data collection, a 12-questions questionnaire consisting of questions about the sociodemographic characteristics, information sources they used about the COVID-19, their thoughts the practices to prevent the transmission of COVID-19 was conducted. Using descriptive statistics and comparison tests, individuals’ perceptions about methods of protection from Covid-19 and related variables were investigated.ResultsThe participants have had sufficient knowledge about Covid-19 and measures.They were using social media platforms, official web sites and TV news to get information about the COVID-19. The rates of believing and applying measures such as staying distant from people, washing hands, staying at home, avoiding from public transportation, using alcohol disinfectants were quite high. The women, people living in large cities, healthcare workers, regular commuters to work believed in measures more, however, their level of anxiety and seeing themselves and their environment at risk were higher.ConclusionsDespite all the positive results regarding coronavirus infection and protection measures, the fact that the epidemic is spreading rapidly indicates the need for studies to continuously evaluate what has changed in the process and as time increases.DisclosureNo significant relationships.
Two-eyed seeing as a philosophy to facilitate communication between indigenous counselors and psychiatry about mind and mental health
Authors: Mainguy B. , Mehl-Madrona L. 
Published: February 2022

IntroductionThe term “two-eyed seeing” is spreading across North America as a concept for explanatory pluralism. The concept was brought into academic science by Albert Marshall, a M’iqmaq from Nova, Scotia, Canada. It speaks to the idea that indigenous knowledge is an equally valid way of conceptualizing a phenomenon as is contemporary science. Marshall’s famous example compares a traditional M’iqmaq story about the origins of the large tides in the Bay of Fundy with contemporary oceanographic geology findings and simulations.ObjectivesWe wanted to explore how this two-eyed seeing model could be applied to mental health to facilitate a dialogue between psychiatry and traditional cultural healers.MethodsWe reviewed the existing literature on two-eyed seeing within mental health care using PubMed, IndexMedicus, OneSearch, and Google Scholar. We presented a course on two-eyed seeing for indigenous mental health services and two-eyed seeing for addressing trauma in indigenous communities and surveyed the participants about the two-eyed seeing concept. We offered this course primarily to providers within indigenous communities and also for other interested counsellors.ResultsParticipants in our trainings were enthusiastic about the role of two-eyed seeing for improving communication among indigenous providers and patients and non-indigenous providers. Most indigenous counselors had not heard of two-eyed seeing and were quite enthusiastic about its affirming nature and how it gave them a basis for dialogue with non-indigenous practitioners.ConclusionsTwo-eyed seeing allows a rich dialogue between European-derived practitioners and indigenous people that enabls each to appreciate the other’s perspectives, leading to greater cooperation and collaborative treatment.DisclosureNo significant relationships.
Baseline EEG-correlates of responders/non-responders to combined antidepressive treatment including transcranial magnetic stimulation
Authors: Iznak E. , Iznak A. , Oleichik I. 
Published: February 2022

IntroductionUse of combined antidepressive treatment included high-frequency rhythmic transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is one of the ways for overcoming of pharmaco-resistance in depressive patients.ObjectivesThe aim of the study was the search for possible EEG predictors of antidepressive effects of rTMS of the left DLPFC in combined treatment of depression.Methods30 female in-patients (F31.3, F33.0, F33.1, by ICD-10; 20-50 years, mean age 36.9±10.3) with pharmaco-resistant depression were enrolled in the study. Treatment included antidepressants (mainly SSRI) and a 3-week course of rTMS (20 Hz) of the left DLPFC. Correlations between pre-treatment EEG spectral power values, and post-treatment quantitative clinical assessments of patients were analyzed. Responders/non-responders were determined by standard criteria of 50% decrease in HDRS-17 scale total scores after treatment course.ResultsResponders (23 out of 30) revealed significant (p<0.05) negative correlations between post-treatment HDRS-17 scores and pre-treatment EEG spectral power in theta-2 (6-8 Hz) and alpha-1 (8-9 Hz) frequency sub-bands in the parietal-occipital-posterior temporal leads. Non-responders (7 out of 30) showed negative correlations between the post-treatment HDRS-17 scores and pre-treatment theta-2 EEG spectral power in the frontal-central-temporal regions of the right hemisphere.ConclusionsEven brief course of rTMS of the left DLPFC enhances the action of antidepressants, and allows overcoming partially the pharmaco-resistance in depressive patients. Baseline values of theta-2 and alpha-1 EEG spectral power may serve as possible predictors of the effects of combined antidepressive therapy including rTMS. The study supported by RBRF grant No.18-01-00029a.DisclosureNo significant relationships.
Individual dynamics of daily life functioning of reward system can predict future level of depressive symptoms
Authors: Kuranova A. , Martinez A. , Wichers M. , Wigman J. , Booij S. 
Published: February 2022

IntroductionThe reward system regulates the processes that motivate people to pursue evolutionary beneficial stimuli. Effective functioning of the reward system can protect against the development of anhedonia. In the daily life, the reward system can be expressed as the dynamic interplay of positive affect (liking), reward anticipation (wanting), and active behavior (engaging). Applying network analysis to daily life experience data allows us to identify such reward dynamics and use them to predict future depressive symptoms.ObjectivesWe investigated whether at baseline (i) higher network positive affect in-strength, reflecting how strongly positive affect is influenced by other components and hence the level of anhedonia, and (ii) higher network connectivity, reflecting overall functioning of the reward system, are associated with fewer depressive symptoms on follow-up.MethodsWe used data from 43 participants with mild depressive symptoms from the SMARTSCAN study. The dynamic interplay between momentary positive affect, reward anticipation, and active behavior was assessed with individual vector-autoregressive models and the network analysis. Network positive affect in-strength and connectivity indices were used to predict a six-month depressive symptoms trajectory.ResultsReward systems networks vary greatly between individuals. On the group level, higher positive affect in-strength (Beta=-3.66, p=0.05) and network connectivity (Beta=-4.06, p=0.03) at baseline were associated with fewer symptoms at follow-up.ConclusionsHigher influences of reward anticipation and active behavior on positive affect and stronger connections between reward cycle components are associated with fewer future symptoms, suggesting the importance of daily life reward cycle dynamics in depression.DisclosureNo significant relationships.
Potential of antithrombin III as a biomarker of antidepressive effect in major depressive disorder
Authors: Song R. , Shi Y. 
Published: February 2022

IntroductionPrevious study has identified increased antithrombin III (ATIII) in patients with major depressive disorder (MDD), supporting ATIII as a potential biomarker for depression diagnosis.ObjectivesThis study aimed to reveal the alteration of ATIII after occipital repetitive transcranial magnetic stimulation (rTMS), and illuminate its power to evaluate and predict the curative effects in MDD treatment.MethodsA total of 90 MDD patients were recruited and further intervened with rTMS in occipital for individualized, standard or sham treatment for five days. Those of 74 patients underwent entire detection, including clinical assessments, blood collection and protein measurement.ResultsAfter treatment, decreased ATIII were detected in both the individualized and the standard group (p=0.000 and 0.001, respectively) instead of the sham one. Especially, the reduction in ATIII in the individualized group was associated with improvements in several neuropsychological assessments. Besides, ATIII at baseline in the standard group and after the individualized rTMS showed high performance to evaluate or predict the response to the 5-day treatment (AUC=0.771, 95%CI, 0.571-0.971; AUC=0.875, 95%CI, 0.714-1.000, respectively) and the remission in follow-up (AUC=0.736, 95%CI, 0.529-0.943; AUC=0.828, 95%CI, 0.656-1.000, respectively). Furthermore, both baseline ATIII and change in ATIII involved in the prediction of 24-item Hamilton Depression Rating Scale in the follow-up study with significant predictive values (p=0.0240 and 0.0233, respectively).ConclusionsThis study detected a reduction in ATIII after occipital rTMS, further revealed the relationships between change in ATIII and therapeutic response, and ultimately provided evidence for the potential of ATIII as a biomarker for the evaluation and prediction of antidepressive effect.DisclosureNo significant relationships.
Identification of risk-factors for the development of depressive symptoms in perinatal period: A longitudinal study
Authors: Vece A. , Tarantino G. , Carfagno M. , Raia M. , Ciampi C. , Vincenzo M. Di , Pitocco A. , Sampogna G. , Luciano M. , Torella M. , Fiorillo A. 
Published: February 2022

IntroductionPerinatal depression is a severe and disabling condition, which affects negatively both mothers’ and children’s mental health and well-being. About 12.8% of pregnant women report depressive symptoms in the perinatal period.ObjectivesThe aims of the present study are to: 1) identify factors (socio-demographic and clinical) associated with an increased risk of developing PD; 2) promote a screening program on PD.MethodsAll pregnant women were assessed at each trimester of pregnancy, three days after the childbirth and after 1, 3, 6 and 12 months, with the Edinburgh Postpartum Depression Scale (EPDS). Women scoring ≥10 on the EPDS were invited to receive a full psychiatric evaluation to confirm the diagnosis.Results420 women were recruited. 52.9%, 27.6% and 31.6% of participants presented an EPDS≥ 10 score at The I, II and III trimester of pregnancy, respectively. The percentage of patients with and EPS score ≥19 is 16.6%, 6.8%, 6.8%, 11.3% and 7.8% in 3 days following the childbirth and after 3, 6, 9 and 12 months, respectively. Higher EPDS scores are predicted by the presence of anxiety symptoms before pregnancy and of depressive and anxiety symptoms in previous pregnancies (p<0.05). Women with family conflicts and with anxiety symptoms in the partner are more likely to report higher EPDS scores (p<0.001).ConclusionsOur results confirm that perinatal depression is a highly prevalent condition. An early identification of depressive symptoms during this period is crucial in order to reduce the long-term negative impact on the mothers, the newborn and other family members.DisclosureNo significant relationships.
A specific “at risk” profile related to recent stressful life events in euthymic major depressive disorder
Authors: Serafini G. , Gonda X. , Aguglia A. , Amerio A. , Canepa G. , Geoffroy P. , Pompili M. , Amore M. 
Published: February 2022

IntroductionStressful life events (SLE) may influence the illness course and outcome.ObjectivesThe present study aimed to characterize socio-demographic and clinical characteristics of euthymic major depressive disorder (MDD) outpatients with SLE relative to those without.MethodsThis sample included 628 (mean age=55.1 ± 16.1) currently euthymic MDD outpatients, among them 250 (39.8%) reported SLE and 378 (60.2%) did not.ResultsAfter univariate analyses, outpatients with SLE were most frequently widowed and lived predominantly with friends/others. Furthermore, compared to outpatients without SLE, those with SLE were more likely to have a family history of suicidal behavior, manifested melancholic characteristics and higher Coping Orientation to the Problems Experienced (COPE) positive reinterpretation/growth and less likely to manifest a comorbid panic disorder, residual interepisodic symptoms, have used psychiatric medications, and use current antidepressant medications. After regression analyses, having a family history of suicide (OR=9.697; p=≤.05), history of psychotropic medications use (OR=2.888; p=≤.05), and reduced use of antidepressants (OR=.321; p=.001) were significantly associated with SLE. Mediation analyses demonstrated that the association between current use of antidepressants and SLE was mediated by previous psychiatric medications.ConclusionsHaving a family history of suicide, history of psychotropic medications use, and reduced use of antidepressants may confer a specific “at risk” profile related to the enhanced vulnerability to experience SLE.DisclosureNo significant relationships.
Program esilence 1.0 - self-regulation program in food education via instagram-loricorps, study protocol
Authors: Lemieux V. , Monthuy-Blanc J. , Moreau N. 
Published: February 2022

IntroductionSocial medias are seen as a risk factor for mental health because they increase body dissatisfaction and decrease self-esteem. This program is based on alimentation and physical well-being by relying on integrated intuitive eating and physical self-esteem. This program, implemented in a community setting use social media (i.e. Instagram-Loricorps), is composed of 12 monthly 180-second video capsule that address themes related to the promotion of body sensations and intuitive movement.ObjectivesThe main objective of this study is to evaluate the effects of the program into the physical environment targeting the physical self-perceptions (PSP). Specifically, this study evaluates whether the eSILENCE 1.0 Program improves the level of PSP related to nutrition and explores the changes in the level and variability of the PSP.MethodsThis project is a mixed sequential explanatory study. 300 participants (Experimental Group [EG; N=200], Control Group [CG; N=100]) are targeted. Online nomothetic questionnaires evaluate occupational changes and PSP in relation to alimentation and are completed by the EG and the CG at pre-test, mid-test and post-test. Online idiographic questionnaires assess PSP and are completed by the EG before and after each video capsule and by the CG once a month without viewing the capsules. Following a preliminary analysis, a focus group will be formed to explain and deepen these results. Participants (N=5) will be recruited voluntarily into the EG.Resultsto come.ConclusionsAnalysis of quantitative data will be used to assess the effectiveness of the program and analysis of qualitative data will provide an in-depth understanding of the linkages between the variables.DisclosureNo significant relationships.
Dysregulated sexuality and childhood trauma in eating disorders: Psychopathological, biological, and behavioural correlates
Authors: D’Anna G. , Castellini G. , Rossi E. , Cassioli E. , Appignanesi C. , Monteleone A.M. , Rellini A.H. , Ricca V. 
Published: February 2022

IntroductionSexual dysfunction is common in eating disorders (EDs), but its relevance is often overlooked.ObjectivesTo describe different ED clinical subgroups in terms of psychopathology, putative biological correlates, and consequences of dysregulated sexuality, focusing on the role of childhood trauma.MethodsHealthy controls (n=60), binge-purging (n=38), and restricting patients (n=24) were compared (age- and BMI-adjusted ANOVA; Bonferroni post-hoc tests), using total scores of Eating Disorder Examination Questionnaire (EDE-Q), Emotional Eating Scale (EES), SCL-90-R Global Severity Index (GSI), Barratt Impulsiveness Scale (BIS-11), Difficulties in Emotion Regulation Scale (DERS), Childhood Trauma Questionnaire (CTQ), Female Sexual Functioning Index (FSFI), Hypersexual Behaviour Inventory (HBI), and patients’ hormonal profiles (gonadal and pituitary hormones, ghrelin). Self-reported voluntary termination of pregnancy (VTP) and promiscuous sexual activity were recorded. For ED patients (N=62), regression analyses between significant variables and HBI were carried, applying moderation models for different CTQ scores.ResultsTable 1 outlines significant between-group comparisons (°: different from controls; *: different from restricting patients; p<0.05). Binge-purging patients had higher FSH, LH, and ghrelin levels, more VTPs and promiscuity. HBI showed significant correlations with EES, SCL-90-R-GSI, DERS, CTQ, and ghrelin levels. CTQ moderated interactions for DERS and EES (Figure 1).Binge-purgingRestrictingControlsFEDE-Q3.86±1.20°3.41±1.64°0.85±0.8367.32EES40.85±22.74°*16.01±15.8819.87±15.217.01SCL-90-R GSI1.73±0.65°1.27±0.69°0.68±0.4420.32BIS-1162.47±9.91°60.81±8.5657.04±10.044.99DERS106.97±29.15°*83.97±33.1278.14±14.1210.21CTQ55.32±21.06°49.31±10.81°38.02±8.3215.24FSFI17.32±11.89°*11.70±10.98°29.32±7.4524.02HBI28.75±13.89*20.56±3.1226.11±4.904.92ConclusionsDysregulated sexuality is linked to emotion dysregulation and childhood trauma. Binge-purging patients experience adverse behavioural consequences.DisclosureNo significant relationships.