bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Pengaruh Electronic Word of Mouth melalui Instagram terhadap Brand Image dan Purchase Intention
Authors: Andriyani Bianka , Fitriani Ni  Made , Rahardja Conny Tjandra 
Published: August 2022

Penelitian ini bertujuan untuk menganalisis pengaruh electronic word of mouth terhadap brand image dan purchase intention serta pengaruh variabel brand image terhadap purchase intention pada Karsa Moyang.
Sampel dalam penelitian ini adalah pengguna aktif Instagram pengikut brand Karsamoyang dan terdapat 84 sampel yang digunakan. Data yang digunakan adalah data primer. Metode pemilihan sampel yang digunakan dalam penelitian ini adalah metode purposive sampling. Metode analisis yang digunakan adalah SEM Warppls dengan melakukan perhitungan nilai goodness of fit dan pengujian hipotesis.
Setelah melakukan pengujian, peneliti mendapatkan kesimpulan yaitu variabel electronic word of mouth memberikan pengaruh positif dan signifikan terhadap brand image. Variabel electronic word of mouth memberikan pengaruh positif dan signifikan terhadap purchase intention. Variabel brand image memberikan pengaruh positif dan signifikan terhadap purchase intention.
Kata Kunci: electronic word of mouth, brand image, purchase intention.
STRATEGI PEMBELAJARAN IPS MASA PANDEMI COVID-19 DI SMP LABORATORIUM KOTA JAMBI
Authors: Satriyo Pamungkas Herlina Andriani, 
Published: August 2022

AbstrakPeneltian berawal dari fenomena non alam yang terjadi berupa virus covid-19 yang berdampak pada pendidikan untuk melaksanakan proses pembelajaran secara daring atau belajar dari rumah yang diterapkan pada setiap lembaga pendidikan termasuk di SMP Laboratorium Kota Jambi. Penelitian ini bertujaun untuk mengetahui strategi pembelajaran yang diterapkan dalam pembelajaran IPS sudah efektif dan mengetahui strategi yang diterapkan guru dan pihak sekolah dalam mengatasi kendala dalam pelaksanaan pembelajaran. Metode penelitian yang digunakan dalam penelitian ini adalah kualitatif deskriptif yang dilaksanakan di SMP Laboratorium Kota Jambi. Subjek dalam penelitian ini adalah guru, siswa, dan kepala sekolah. Teknik pengumpulan data dilakukan dengan observasi, wawancara, dan dokumentasi. Berdasarkan hasil penelitian yang dilakukan menunjukkan bahwa, strategi yang digunakan guru IPS dalam pelaksanaan pembelajaran memanfaatkan produk teknologi, strategi pembelajaran yang digunakan yaitu strategi ekspositori, Strategi Pembelajaran Inkuiri, dan strategi pengembangan berpikir. Kurangnya sarana dan prasarana yang disebabkan oleh faktor ekonomi sekolah, dan adanya biaya anggaran tambahan yang harus dikeluarkan orang tua siswaKata Kunci: Pembelajaran Daring, Mata Pelajaran IPS. AbstractThe research started from a non-natural phenomenon that occurred in the form of the covid-19 virus which had an impact on education to carry out the online learning process or study from home which was applied to every educational institution, including the Jambi City Laboratory Junior High School. This study aims to find out the learning strategies applied in social studies learning have been effective and to find out the strategies applied by teachers and schools in overcoming obstacles in the implementation of learning. The research method used in this research is descriptive qualitative which was carried out at the Jambi City Laboratory Junior High School. The subjects in this study were teachers, students, and school principals. Data collection techniques were carried out by observation, interviews, and documentation. Based on the results of the research conducted, it shows that the strategies used by social studies teachers in implementing learning utilize technology products, the learning strategies used are expository strategies, inquiry learning strategies, and thinking development strategies. Lack of facilities and infrastructure caused by school economic factors, and additional budget costs that must be paid by parentsKeywords: Online Learning, Social Studies Subjects.
Knowledge and Attitude to Biomedical Research of the Post-Graduate Medical Students in Bangladesh
Authors: Yasmin Nelofar , Paul Shubhra Prakash , Haque Md Jawadul , Karim Md Rizwanul , Kumer Shathi , Kamal Rawsan , Syem Md Abu , Ullah Shah Amanath , Parvin Most Firoza , Kowsarunnahar - 
Published: August 2022

Background: Research is the integral part of post-graduation course curriculum. If steps are not taken at an early stage by medical postgraduates who will walk in the path of research in future, the quality of research and its application may be compromised. Students had variable perceptions towards research. The findings of this study could provide insights to improve research training.
Objectives: The aim of this study was to assess knowledge and to find out attitude to biomedical research of the post-graduate medical students in Bangladesh. Materials & Methods: This cross-sectional type of descriptive study was carried out in the community Medicine Department of Rajshahi Medical College over a period of 12 months from January to December 2020 among the post-graduate students of different medical colleges. Approval from the Ethical Review Committee (ERC) was obtained prior to the commencement of the study. Purposive sampling technique was used. Pre-designed, validated, structured questionnaire was used to gather information from 325 participants on knowledge and 5-point Likert scale was used for assessment of attitude.
Results: In this study excellent knowledge was considered in ≥ 80% correct answers and positive attitude was considered in ≥ 60 score. Out of the 325 study respondents, majority (53.5%) of them were male and pursuing post-graduation in different subjects. Among the respondents, 145 (44.6%) of students had good knowledge, 119 (36.60%) of students had excellent knowledge and 190 (58.5%) had positive attitude toward medical research. Relationship of level of knowledge on biomedical research was not statistically significant for age, sex, religion, marital status, parental and spouse educational status (P>0.05). But association of knowledge was statistically significant for running post-graduation course, type of research involvement and type of medical college of MBBS passing (P < 0.05). Relationship of attitude to biomedical research of the respondents was not statistically significant for age, religion, type of research involvement, type of medical college of MBBS passing, running post-graduation course, marital status, parental and spouse educational status (P>0.05). But male had more positive attitude to biomedical research than female (P<0.05).
Conclusion: The study revealed that the respondents had a good knowledge and positive attitude toward biomedical research but they were not able to transform their knowledge and attitude into actual practices.
TAJ 2022; 35: No-1: 51-61
A prática clínica do enfermeiro na reabilitação estética de pacientes mastectomizadas
Authors: Cesário Jonas Magno dos Santos , Hernandes Luana de Oliveira , Botion Beatriz Mees , Silva Giselle Katrina Aguiar da , Cunha Amanda Priscilla da , Gomes Daiana Moreira , Vitorino Priscila Gramata da Silva , Flauzino Victor Hugo de Paula 
Published: August 2022

O Instituto Nacional de Câncer, o câncer de mama é o segundo tipo de câncer mais comum entre as mulheres no Brasil e no mundo, depois do câncer de pele não melanoma. A mastectomia, mesmo acompanhada de reconstrução mamária imediata, pode ser uma experiência traumática para as mulheres e pode ser percebida como uma mutilação, impactando significativamente sua autoestima e estabilidade emocional. O enfermeiro no processo de reabilitação apresenta uma função de destaque durante o tratamento, na prevenção e na gestão das complicações que podem comprometer a funcionalidade e afetar a qualidade de vida da mulher. O objetivo do trabalho foi identificar as ações do enfermeiro que recuperem a autoestima em pacientes submetidas a mastectomia. A metodologia utilizada foi uma revisão bibliográfica na banca de dados do Google Acadêmico, BVS e SciELO, publicadas entre 2016 e 2022, disponíveis de forma completa. Inicialmente foram encontrados 157 estudos e após a aplicação dos filtros, conforme os critérios de inclusão e exclusão, foram eliminados 138 estudos. Não foram considerados estudos duplicados, monografias, apostilas e livros. Ao final foram incluídos 18 artigos científicos .A desconstrução da imagem feminina pela retirada da mama impacta emocionalmente e psicologicamente a vida das mulheres, neste caso o enfermeiro deve atuar como um facilitador da melhoria da qualidade de ida dessas mulheres e na capacidade de aceitação. Um dos principais objetivos do trabalho do enfermeiro é o de promover uma melhor adaptação da mulher ao novo cenário ao qual ela se encontra. A família pode ser uma grande aliada no apoio emocional as pacientes mastectomizadas, e o enfermeiro deve dar o suporte educacional e emocional necessário nesses casos.
Tratamento conservador da gravidez ectópica íntegra com metotrexato
Authors: Oliveira Isabel Andretto de , Soares Leila Cristina , Monteiro Denise Leite Maia 
Published: August 2022

Introdução: A gravidez ectópica (GE) é definida, de forma geral, como a implantação do blastocisto fora da cavidade uterina, sinônimo de gravidez extrauterina. Objetivo: Analisar a eficácia do tratamento conservador com metotrexato (MTX) na GE íntegra. Métodos: Trata-se de revisão sistemática realizada através de ampla pesquisa na literatura médica utilizando as bases de dados eletrônicas: Medline (PubMed) e LILACS, com a seguinte estratégia de busca: ("Pregnancy, Ectopic"[Majr] AND "Drug Therapy"[Mesh]). Resultados: Os estudos selecionados convergem para a demonstração da eficácia do tratamento conservador com MTX na GE íntegra e foram agrupados em três grupos principais: Pacientes submetidas ao tratamento conservador com MTX no protocolo de dose única (DU), pacientes submetidas ao protocolo de dose dupla (DD) e pacientes submetidas ao tratamento conservador e que não atendem os critérios do protocolo para o uso do MTX. Os resultados mostraram que protocolo de DU de MTX tem eficácia suficiente no tratamento da GE, porém em pacientes fora dos parâmetros exigidos pelo protocolo atual o sucesso do tratamento aumenta com o uso do método de DD ou dose múltipla. Conclusões: O protocolo de DU com a opção de elaborar para uma segunda dose em caso de falha do tratamento pode ser o tratamento ideal para GE íntegra.
Study of key amino acid residues of GH66 dextranase for producing high-degree polymerized isomaltooligosaccharides and improving of thermostability
Authors: Lin Qianru , Wang Huanyu , Xu Yingying , Dong Dongxue , Miao Qingzhen , Lu Jing , Lyu Mingsheng , Wang Shujun 
Published: August 2022

Obtaining high-degree polymerized isomaltose is more difficult while achieving better prebiotic effects. We investigated the mutation specificity and enzymatic properties of SP5-Badex, a dextranase from the GH66 family of Bacillus aquimaris SP5, and determined its mutation sites through molecular docking to obtain five mutants, namely E454K, E454G, Y539F, N369F, and Y153N. Among them, Y539F and Y153N exhibited no enzymatic activity, but their hydrolysates included isomaltotetraose (IMO4). The enzymatic activity of E454G was 1.96 U/ml, which was 3.08 times higher than that before mutation. Moreover, 70% of the enzymatic activity could be retained after holding at 45°C for 180 min, which was 40% higher than that of SP5-Badex. Furthermore, its IMO4 content was 5.62% higher than that of SP5-Badex after hydrolysis at 30°C for 180 min. To investigate the effect of different amino acids on the same mutation site, saturation mutation was induced at site Y153, and the results showed that the enzyme activity of Y153W could be increased by 2 times, and some of the enzyme activity could still be retained at 50°C. Moreover, the enzyme activity increased by 50% compared with that of SP5-Badex after holding at 45°C for 180 min, and the IMO4 content of Y153W was approximately 64.97% after hydrolysis at 30°C for 180 min, which increased by approximately 12.47% compared with that of SP5-Badex. This site is hypothesized to rigidly bind to nonpolar (hydrophobic) amino acids to improve the stability of the protein structure, which in turn improves the thermal stability and simultaneously increases the IMO4 yield.
Process study of ceramic membrane-coupled mixed-cell fermentation for the production of adenine
Authors: Sun Pengjie , Li Changgeng , Gong Yu , Wang Jinduo , Xu Qingyang 
Published: August 2022

In order to solve the problems of high complexity, many by-products, high pollution and difficult extraction of the existing adenine production process, in this study, ceramic membrane-coupled mixed cell fermentation was used to produce adenine while reducing the synthesis of by-products and simplifying the production process of adenine. Nucleoside hydrolase (encoded by the rihC gene) was used to produce adenine by coordinated fermentation with the adenosine-producing bacterium Bacillus Subtilis XGL. The adenosine hydrolase (AdHy)-expressing strain Escherichia coli BL21-AdHy was successfully employed and the highest activity of the crude enzyme solution was found by orthogonal experiments at 170 W power, 42% duty cycle, and 8 min of sonication. The highest AdHy activity was found after 18 h of induction incubation. E. coli BL21-AdHy was induced for 18 h and sonicated under the above ultrasonic conditions and the resulting crude enzyme solution was used for co-fermentation of the strain and enzyme. Moreover, 15% (v/v) of the AdHy crude enzyme solution was added to fermentation of B. subtilis XGL after 35 h. Finally, the whole fermentation system was dialyzed using coupled ceramic membranes for 45 and 75 h, followed by the addition of fresh medium. In contrast, the AdHy crude enzyme solution was added after 35, 65, and 90 h of B. subtilis fermentation, with three additions of 15, 15, and 10% of the B. subtilis XGL fermentation system. The process was validated in a 5 L fermenter and 14 ± 0.25 g/L of adenine was obtained, with no accumulation of adenosine and d-ribose as by-products. The enzymatic activity of the AdHy crude solution treated with ultrasound was greatly improved. It also reduced the cellular activity of E. coli BL21-AdHy and reduced effects on bacterial co-fermentation. Membrane-coupled dialysis solved the problem of decreased yield due to poor bacterial survival and decreased viability, and eliminated inhibition of the product synthesis pathway by adenosine. The batch addition of crude enzyme broth allowed the continuous conversion of adenosine to adenine. This production method provides the highest yield of biologically produced adenine reported to date, reduces the cost of adenine production, and has positive implications for the industrial production of adenine by fermentation. And it provides a reference for producing other high-value-added products made by fermentation.
Cardiovascular adverse events induced by immune checkpoint inhibitors: A real world study from 2018 to 2022
Authors: Wu Si , Bai Hansheng , Zhang Ling , He Jiamin , Luo Xiangru , Wang Shiyi , Fan Guangjun , Sun Na 
Published: August 2022

BackgroundThe reported rate of cardiovascular adverse events (CAE) caused by immune checkpoint inhibitors (ICI) is low but potentially fatal. Assess the risk of CAE in cancer patients and compare the incidence of CAE between Chinese developed ICIs and imported ICIs.MethodsA retrospective analysis was performed on cancer patients treated with ICI for at least four cycles in the Second Affiliated Hospital of Dalian Medical University from January 2018 to March 2022. Baseline characteristics, physiological and biochemical values, electrocardiographic and echocardiographic findings were compared between patients with and without CAE.ResultsAmong 495 patients treated with ICIs, CAEs occurred in 64 patients (12.93%). The median time to the event was 105 days (61–202). The patients with low neutrophil-to-lymphocyte ratio (L-NLR) were significantly associated with the risk of developing CAE (hazard ratio HR 3.64, 95% confidence ratio CI 1.86–7.15, P = 0.000). Patients with higher comorbidity burden significantly increased the risk of developing CAE (HR 1.30, 95% CI 1.05–1.61, P = 0.014). Those who received a combination of ICI and vascular endothelial growth factor receptor (VEGFR) inhibitors (HR 2.57, 95% CI 1.37–4.84, P = 0.003) or thoracic radiation therapy (HR 32.93, 95% CI 8.81–123.14, P = 0.000) were at a significantly increased risk of developing CAE. Compared to baseline values, creatine kinase is -oenzymes (CK-MB) (95% CI -9.73 to -2.20, P = 0.003) and cardiac troponin I (cTnI) (95% CI -1.06 to -0.06, P = 0.028) were elevated, and the QTc interval prolonged (95% CI -27.07 to -6.49, P = 0.002). Using nivolumab as a control, there was no difference in CAE risk among the eight ICIs investigated. However, the results of the propensity matching showed that programmed death-ligand 1 (PD-L1) inhibitors had lower CAE occurrence compared with programmed cell death protein 1 (PD-1) inhibitors (adjusted HR = 0.38, P = 0.045).ConclusionPatients who received concurrent VEGFR inhibitors and ICIs had a history of thoracic radiation therapy, L-NLR, and higher comorbidity burden had an increased risk of CAEs. Elevated cTnI, CK-MB, and QTc, can be used to monitor CAEs. There was no significant difference in CAE risks between Chinese domestic and imported ICIs. PD-L1 inhibitors had lower CAE occurrence than PD-1 inhibitors.
Effects of oral anticoagulant therapy in patients with pulmonary diseases
Authors: Lai Jiying , Feng Shenghui , Xu Shuo , Liu Xin 
Published: August 2022

BackgroundTo evaluate the effect of oral anticoagulants (OACs) therapy, including vitamin K antagonist (VKA) and direct oral anticoagulants (DOAC) in patients with pulmonary diseases.MethodsLiterature from PubMed, MEDLINE, and Cochrane Library were screened until June 2022. Studies assessing OACs for pulmonary hypertension (PH), pulmonary embolism (PE), pulmonary fibrosis (PF), or chronic obstructive pulmonary disease (COPD) were evaluated for inclusion.ResultsOur study indicated that in patients with PH, PE, and COPD, OACs could significantly reduce the mortality risk, and the effects of VKA and DOACs without statistical difference in reducing the risk of recurrent embolism events. In patients with sclerosis-associated pulmonary arterial hypertension (SSc-PAH) or idiopathic pulmonary fibrosis (IPF), vitamin K antagonist (warfarin) significantly increased the mortality risk, while DOACs were not. As for the safety outcome of OACs, existing studies indicate that compared with patients treated with warfarin, the users of DOAC have a lower risk of major bleeding, while there is no statistical significance between them in non-major bleeding events. In current guidelines, the anticoagulation regimen for patients with pulmonary disease has not been defined. The results of our study confirm that DOACs (apixaban, rivaroxaban, dabigatran, and edoxaban) are superior to VKAs in the efficacy and safety outcomes of patients with pulmonary disease.ConclusionsOral anticoagulant therapy brings benefits to patients with PH, PE, or COPD, while the anticoagulation regimen for patients with SSc-PAH or IPF requires serious consideration. Compared with VKA, DOAC is a non-inferior option for anticoagulation in pulmonary disease treatment. Further studies are still needed to provide more reliable evidence about the safety outcome of pulmonary disease anticoagulation.
Applicability evaluation of multiple sets of soil moisture data on the tibetan plateau
Authors: Dong Xuefeng , Lai Xin , Wang Yingsi , Dong Wei , Zhu Jun , Dong Li , Cen Sixian 
Published: August 2022

Based on the in situ data of the soil moisture-observation networks established at Maqu, Naqu, Ali, and Shiquanhe (Sq) on the Tibetan Plateau (TP), and using five evaluation indices [Pearson correlation coefficient (R), root mean square error (RMSE), mean deviation (bias), standard deviation ratio (SDV), and unbiased RMSE (ubRMSE)], the applicability of soil moisture datasets [COMBINED, ACTIVE, PASSIVE, ERA5, ERA5-Land (LAND), ERA-Interim (INTERIM), CLSM, and NOAH] was comprehensively evaluated. The results showed that, at the observation-network scale, ACTIVE exhibited the best applicability in Maqu (R = 0.704, ubRMSE = 0.040 m3/m3), COMBINED performed best in Naqu (R = 0.803, bias = 0.016 m3/m3), LAND displayed the best consistency with observations in Ali (R = 0.734, bias = −0.035 m3/m3), and ERA5 not only showed the best performance in Sq (R = 0.793, bias = −0.037 m3/m3) but also exhibited good results in the other three observation networks (R &gt; 0.6). In a smaller-scale evaluation in Maqu, ACTIVE performed best, followed by ERA5. The COMBINED and PASSIVE products had serious gaps in Ali and Sq, and had the worst applicability in the western TP. In conclusion, considering the correlation results and temporal and spatial continuities, ERA5 is the most suitable soil moisture dataset for the TP.
A novel ferroptosis-related gene prognostic index for prognosis and response to immunotherapy in patients with prostate cancer
Authors: Wang Yuliang , Fan Jiaqi , Chen Tao , Xu Lele , Liu Pengyu , Xiao Lijia , Wu Tao , Zhou Qingchun , Zheng Qingyou , Liu Chunxiao , Chan Franky Leung , Wu Dinglan 
Published: August 2022

BackgroundProstate cancer (PCa) is among the leading causes of cancer death worldwide. Ferroptosis refers to an iron-dependent form of regulated cell death and is involved in prostate tumorigenesis. A few ferroptosis-related gene signatures have been developed to predict the prognosis for PCa patients. However, previous signatures were typically established based on biochemical recurrence-free survival, which has proven not to be a good surrogate for overall survival (OS). This study aimed to construct a novel ferroptosis-related gene prognostic index (FRGPI) to predict disease-free survival (DFS) and response to immunotherapy for PCa patients after radical prostatectomy.MethodsGene expression and clinicopathological data on PCa patients were obtained from the TCGA database. Ferroptosis-related hub genes associated with DFS of PCa patients were identified by an in-depth bioinformatics analysis using a novel and comprehensive algorithm based on functional enrichment, consensus clustering, weighted gene co-expression network analysis (WGCNA), and protein-protein interaction (PPI) network construction. The FRGPI was established on the basis of the genes selected using multivariate cox regression analysis and further validated in two additional PCa cohorts. Next, the clinicopathological, molecular, and immune profiles were characterized and compared between FRGPI-high and FRGPI-low subgroups. Finally, the predictive role of the FRGPI in response to immunotherapy was estimated using a metastatic urothelial cancer cohort treated with an anti-PD-L1 agent.ResultsThe FRGPI was constructed based on four genes (E2F1, CDC20, TYMS, and NUP85), and FRGPI-high patients had worse DFS than FRGPI-low patients. Multivariate cox regression analysis revealed that FRGPI could act as an independent prognostic factor for PCa patients after radical prostatectomy. A prognostic nomogram comprising the FRGPI and other clinicopathological parameters was established to predict the DFS for PCa patients quantitatively. In addition, comprehensive results demonstrated that high FRGPI scores showed a significantly positive correlation with worse clinicopathological features, higher mutation counts, increased frequency of copy number variations (CNVs), higher homologous recombination deficiency (HRD) and immune scores, higher mRNAsi, and more importantly, enhanced sensitivity to immunotherapy.ConclusionsFRGPI is not only a promising and robust prognostic biomarker, but also a potential indicator of immunotherapeutic outcomes for PCa patients after radical prostatectomy.