bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-licensure medical students’ knowledge and views on interprofessional learning: A qualitative concept analysis based on real-world data
Authors: Berger-Estilita Joana , Merlo Sofia , Guttormsen Sissel , Fuchs Alexander , Greif Robert , Chiang Hsin 
Published: August 2022

BackgroundThe several definitions of Interprofessional Education (IPE) allow for different interpretations and interchangeable terms. This study aims to determine the characteristics and attributes of the definition of IPE.Materials and methodsIn November 2019, 31 medical students (64.5% female) from a single institution took part in nine semi-structured interviews. We created a deductive three-level code system followed by an inductive code system based on several known IPE definitions. We extracted the main entities of the concept of IPE according to both code systems to create a framework. We used MaxQDA software for qualitative analysis. Verification of codes and categories was attained through sequential peer-debrief.ResultsParticipants correctly named the WHO’s definition of IPE, and outlined its four main dimensions according to the Interprofessional Education Collaborative report. We found new IPE attributes and demonstrated the weight of communication and role recognition. Two-thirds of medical students mentioned IPE activities that we classified as a contrary model (without collaboration or patient-centeredness) and a minimum weight was given to the importance of patient-centeredness.ConclusionMedical students’ understanding of the concept of IPE is coherent. We deepened the understanding of previously identified definitions of IPE, and we identified new attributes of the concept. Finally, we added “well-being” as a component of interprofessionality.Clinical Trial Registration[https://www.isrctn.com/], identifier [ISRCTN41715934].
Predictors of consciousness improvement in patients with hypoglycemic encephalopathy
Authors: Lee Yu Eun , Lee Eun Ja , Lee Seung Eun , Park Jinkyeong 
Published: August 2022

AimsHypoglycemic encephalopathy (HE) can cause long-lasting mental changes, disability, and even death. We aimed to investigate prognostic factors for HE and to determine when the treatment of HE becomes futile.MethodsWe retrospectively evaluated the data of patients admitted for prolonged HE at Dongguk University Ilsan Hospital between December 2005 and July 2021. We assessed the Glasgow Outcome Scale (GOS) to assess functional outcome.ResultsForty-four patients were enrolled in the study. Thirty-two of these showed the improvement on GOS after treatment. Patients with improved consciousness had a shorter duration of hypoglycemia (1.6±1.4 vs. 7.8±15.0 hours, p = 0.04) and a lower incidence of brain lesions than those without improvements in consciousness (76.0% vs. 25.0%, p &lt; 0.01). Patients whose lesions were detected in initial MRIs were 1.3 times less likely to recover consciousness after HE (odds ratios, 1.28; 95% CI, 1.09-1.52; p &lt; 0.01). None of the patients recovered consciousness after 320 h. Maximum time spent to recover was 194 in patients without brain lesions and 319 in those with lesions.ConclusionsHypoglycemic brain injury detected in initial MRIs predicted poorer HE prognosis. Nevertheless, treatment should be provided for at least for 14 days after admission.
Nexus Between Equity Pricing Models and Equity Price Fragility: Empirical Insights From Pakistan
Authors: Anser Muhammad Khalid , Yusop Zulkornain , Abbas Shujaat , Ali Sajid , Ahmad Munir 
Published: August 2022

Purpose: The study tests conventional and behavioral pricing multifactor impact on price fragility from the equity market of Pakistan.Methodology: The positivist approach is used to deduct study rationale via probability sampling. At the same time, systematic sampling for data collection of PSX is tested in parallel to mean-variance random walk theory.Findings: The impact of conventional factors is significant on price fragility in the short run and vice versa in the long run. Specifically, herd behavior and disposition effects are found to be insignificant. But size, value, illiquidity, and price earning had a significant impact on price fragility in the short run.Limitations: The current research has not covered the desired scope of the topic due to time limitations, lack of harmony in corporate data on databases, and literature on price fragility being very scarce.Implication: In PSX, there is a need to develop a corporate culture to promote the standard modern financial practice to enhance financial productivity and sustainability. For corporate culture to be established, corporate governance boards should be established, and family governance systems should be replaced by an independent democratic board. Mispricing and arbitragers need serious control.Originality: The value of the research is that little research currently exists on about pricing multifactor impact on price fragility.
Base-flow segmentation and character analysis of the Huangfuchuan Basin in the middle reaches of the Yellow River, China
Authors: Zhang Yaru , He Yi , Mu Xingmin , Jia Liping , Li Yanlin 
Published: August 2022

In recent years, with the deterioration of the ecological environment, runoff in the Yellow River has been decreasing. Given these phenomena, it is necessary to research the base-flow segmentation methods and its characteristics. The Huangfuchuan Basin in the middle reaches of the Yellow River basin was selected as the research area. This paper calculated the base-flow with commonly used base-flow segmentation methods, including Base-flow index method (BFI), Hydrograph-separation techniques (HYSEP), and the digital filtering methods, and compared the applicability of these methods in the study area. Then the variation characteristics, abrupt change year, periodic change, and future trend of the base-flow were analyzed. The results are as follows: 1) Through the analysis and comparison of several common base-flow segmentation methods, these methods had a marked difference in base-flow segmentation. The variance and extreme-ratio of DF4 in the digital filtering methods were small. The correlation between DF4 and other methods was high. DF4 in the digital filtering methods was the most appropriate method in the research area. 2)The runoff and base-flow index presented a decreasing trend. The annual average runoff was 1,100.27 × 104 m3, and the maximum base-flow was 0.21. The base-flow also showed a significant decrease trend by the Mann-Kendall trend test, the average base-flow was 10,578.35 × 104 m3. 3) The base-flow had periodic variations of 3–6, 7–18, and 19–32. In the 19–32 years time scale, three oscillations alternated between abundant and dry. The whole time was 31 years as the center of the periodic change, the first primary cycle of base-flow change. 4) The base-flow mutation occurred in 1986. The Hurst index of base-flow in the Huangfuchuan Basin was 0.84. It was shown that the trend of future development is positively correlated with past change, showing a trend of continuous decrease. Selecting the appropriate method of base-flow segmentation and reasonably analyzing the variation characteristics of base-flow can provide scientific guidance for the ecological environment construction and water resource evaluation in the Huangfuchuan Basin and even the Yellow River Basin.
Systematic review of gastric cancer-associated genetic variants, gene-based meta-analysis, and gene-level functional analysis to identify candidate genes for drug development
Authors: Lee Sangjun , Yang Han-Kwang , Lee Hyuk-Joon , Park Do Joong , Kong Seong-Ho , Park Sue K. 
Published: August 2022

Objective: Despite being a powerful tool to identify novel variants, genome-wide association studies (GWAS) are not sufficient to explain the biological function of variants. In this study, we aimed to elucidate at the gene level the biological mechanisms involved in gastric cancer (GC) development and to identify candidate drug target genes.Materials and methods: We conducted a systematic review for GWAS on GC following the PRISMA guidelines. Single nucleotide polymorphism (SNP)-level meta-analysis and gene-based analysis (GBA) were performed to identify SNPs and genes significantly associated with GC. Expression quantitative trait loci (eQTL), disease network, pathway enrichment, gene ontology, gene-drug, and chemical interaction analyses were conducted to elucidate the function of the genes identified by GBA.Results: A review of GWAS on GC identified 226 SNPs located in 91 genes. In the comprehensive GBA, 44 genes associated with GC were identified, among which 12 genes (THBS3, GBAP1, KRTCAP2, TRIM46, HCN3, MUC1, DAP3, EFNA1, MTX1, PRKAA1, PSCA, and ABO) were eQTL. Using disease network and pathway analyses, we identified that PRKAA, THBS3, and EFNA1 were significantly associated with the PI3K-Alt-mTOR-signaling pathway, which is involved in various oncogenic processes, and that MUC1 acts as a regulator in both the PI3K-Alt-mTOR and P53 signaling pathways. Furthermore, RPKAA1 had the highest number of interactions with drugs and chemicals.Conclusion: Our study suggests that PRKAA1, a gene in the PI3K-Alt-mTOR-signaling pathway, could be a potential target gene for drug development associated with GC in the future.Systematic Review Registration: website, identifier registration number.
Comprehensive circular RNA expression profile of lung adenocarcinoma with bone metastasis: Identification of potential biomarkers
Authors: Cai Ying , Zhu Chunlan , Wang Yanfei , Jiang Yiqian , Zhu Zhongxin 
Published: August 2022

Background: Lung adenocarcinoma (LUAD) has a significant tendency to metastasize to the bone, with severe comorbidities. Recent studies have reported that circular RNAs (circRNAs) are involved in various cancer metastasis-related physiological cellular processes. However, their role in LUAD with bone metastasis (LUAD-BM) remains unknown.Methods: Bone metastasis (BM) circRNAs were identified using high-throughput sequencing and validated by quantitative reverse transcription-PCR (qRT-PCR). Bioinformatic analyses were used to predict the potential functions of the differentially expressed circRNAs. The effects of circ_0096442 on the growth and metastasis of A549 cells were detected in a co-culture system of A549 and bone marrow-derived cells.Results: There were 598 (238 upregulated and 360 downregulated) 390 (187 upregulated and 203 downregulated) and 644 (336 upregulated and 308 downregulated) differentially expressed circRNAs between LUAD-BM and LUAD, LUAD-BM and healthy individuals, and LUAD and healthy individuals, respectively. These differentially expressed circRNAs play important roles in cellular components, biological processes, and molecular functions. Moreover, they map several pathways related to BM, including DNA repair, DNA damage, and osteoclast differentiation. The results validated by qRT-PCR for the five most dysregulated circRNAs are consistent with the sequencing data. Additionally, circ_0096442 was found to promote the growth and metastasis of LUAD in a bone microenvironment.Conclusion: Our findings provide a novel and important circRNA expression profile of LUAD-BM and suggest that circ_0096442 may be a biomarker for LUAD-BM.
Effect of macular vascular density on visual quality in young myopic adults
Authors: Wang Xueqing , Xia Likun 
Published: August 2022

ObjectiveTo evaluate macular vascular density using optical coherence tomography angiography (OCTA) and to investigate its impact on best-corrected visual acuity (BCVA), contrast sensitivity function (CSF), and higher-order aberrations (HOAs) in young myopic adults.MethodsThis cross-sectional study included 109 eyes with axial length (AL) between 22 and 26 mm in the medium AL group and 90 eyes with AL &gt; 26 mm in the long AL group. OCTA was used to obtain 3 × 3 mm en face images, and the vessel length density (VLD), perfusion density (PD), and fovea avascular zone (FAZ) of the superficial layer were evaluated. Visual quality was assessed using the CSF and HOAs.ResultsSignificant differences were found in the inferior VLD, parafoveal PD, and FAZ areas between the groups. AL and macular vascular density showed negative correlations in the inferior and nasal areas. The spherical correction (SE) also showed a positive correlation with vascular density in these two areas. FAZ area and perimeter had a significant negative association with AL, and FAZ circularity was correlated with SE. CSF with bright around 6 and 12 spatial frequencies showed positive correlations with nasal PD. The parafoveal PD showed a significant correlation with BCVA after adjusting for other factors.ConclusionThe superficial macular vascular density of young myopic adults decreased with lower SE and longer AL in the parafovea area. An eye with a long AL has a smaller FAZ, and myopia decreases the FAZ circularity index. The decrease in vessel density could contribute to worse BCVA and may be correlated with lower CSF, but not with HOAs.
Perspectives and mechanisms for targeting ferroptosis in the treatment of hepatocellular carcinoma
Authors: Li Lanqing , Wang Xiaoqiang , Xu Haiying , Liu Xianqiong , Xu Kang 
Published: August 2022

Ferroptosis is a novel process of regulated cell death discovered in recent years, mainly caused by intracellular lipid peroxidation. It is morphologically manifested as shrinking of mitochondria, swelling of cytoplasm and organelles, rupture of plasma membrane, and formation of double-membrane vesicles. Work done in the past 5 years indicates that induction of ferroptosis is a promising strategy in the treatment of hepatocellular carcinoma (HCC). System xc-/GSH/GPX4, iron metabolism, p53 and lipid peroxidation pathways are the main focus areas in ferroptosis research. In this paper, we analyze the ferroptosis-inducing drugs and experimental agents that have been used in the last 5 years in the treatment of HCC. We summarize four different key molecular mechanisms that induce ferroptosis, i.e., system xc-/GSH/GPX4, iron metabolism, p53 and lipid peroxidation. Finally, we outline the prognostic analysis associated with ferroptosis in HCC. The findings summarized suggest that ferroptosis induction can serve as a promising new therapeutic approach for HCC and can provide a basis for clinical diagnosis and prevention of this disease.
Galanin analogs prevent mortality from seizure-induced respiratory arrest in mice
Authors: Collard Ryley , Aziz Miriam C. , Rapp Kevin , Cutshall Connor , Duyvesteyn Evalien , Metcalf Cameron S. 
Published: August 2022

ObjectiveSudden Unexpected Death in Epilepsy (SUDEP) accounts for 20% of mortality in those with recurrent seizures. While risk factors, monitoring systems, and standard practices are in place, the pathophysiology of SUDEP is still not well understood. Better knowledge of SUDEP and its potential mechanisms of action is crucial to reducing risk in this patient population and developing potential treatment options. Clinical studies and animal models of SUDEP suggest that diminished post-ictal respiratory control may be the dominant mechanism contributing to mortality. Recently, it was demonstrated that the depletion of the neuropeptide galanin in the amygdala occurs in human SUDEP. The amygdala plays a key role in the central integration of respiratory signaling; the depletion of galanin may represent a critical change that predisposes individuals to SUDEP.Materials and methodsTo evaluate the impact of enhancing galaninergic signaling to potentially protect against SUDEP, we studied seizure-induced respiratory arrest (S-IRA) following central (intracerebroventricular, intra-amygdala) and systemic (intraperitoneal, subcutaneous) administration of galanin analogs. Seizure naïve and seizure experienced (fully kindled) mice were tested.ResultsCentral and systemically administered galanin analogs protect against S-IRA in naïve C57Bl/6J mice. Differential efficacy between receptor subtype-selective analogs varied based on the route of administration. Sub-chronic systemic administration at doses that reduced 6 Hz seizures also protected against S-IRA. Acute treatment benefits also extended to fully kindled mice experiencing tonic extension.SignificanceThese data demonstrate that galanin analogs may be protective against post-ictal respiratory collapse.
The effect of denture-wearing on physical activity is associated with cognitive impairment in the elderly: A cross-sectional study based on the CHARLS database
Authors: Chen Yisheng , Luo Zhiwen , Sun Yaying , Zhou Yifan , Han Zhihua , Yang Xiaojie , Kang Xueran , Lin Jinrong , Qi Beijie , Lin Wei-Wei , Guo Haoran , Guo Chenyang , Go Ken , Sun Chenyu , Li Xiubin , Chen Jiwu , Chen Shiyi 
Published: August 2022

BackgroundCurrently, only a few studies have examined the link between dental health, cognitive impairment, and physical activity. The current study examined the relationship between denture use and physical activity in elderly patients with different cognitive abilities.MethodsThe study data was sourced from the 2018 China Health and Retirement Longitudinal Study (CHARLS) database, which included information on denture use and amount of daily physical activity undertaken by older persons. Physical activity was categorized into three levels using the International Physical Activity General Questionnaire and the International Physical Activity Scale (IPAQ) rubric. The relationship between denture use and physical activity in middle-aged and older persons with varying degrees of cognitive functioning was studied using logistic regression models.ResultsA total of 5,892 older people with varying cognitive abilities were included. Denture use was linked to physical activity in the cognitively healthy 60 + age group (p = 0.004). Denture use was positively related with moderate physical activity in the population (odds ratio, OR: 1.336, 95% confidence interval: 1.173–1.520, p &lt; 0.001), according to a multivariate logistic regression analysis, a finding that was supported by the calibration curve. Furthermore, the moderate physical activity group was more likely to wear dentures than the mild physical activity group among age-adjusted cognitively unimpaired middle-aged and older persons (OR: 1.213, 95% CI: 1.053–1.397, p &lt; 0.01). In a fully adjusted logistic regression model, moderate physical activity population had increased ORs of 1.163 (95% CI: 1.008–1.341, p &lt; 0.05) of dentures and vigorous physical activity population had not increased ORs of 1.016 (95% CI: 0.853–1.210, p &gt; 0.05), compared with mild physical activity population.ConclusionThis findings revealed that wearing dentures affects physical activity differently in older persons with different cognitive conditions. In cognitively unimpaired older adults, wearing dentures was associated with an active and appropriate physical activity status.
Identification of PLAUR-related ceRNA and immune prognostic signature for kidney renal clear cell carcinoma
Authors: Wang Yu , Sun Zhuolun , Lu Shuo , Zhang Xu , Xiao Chutian , Li Tengcheng , Wu Jieying 
Published: August 2022

Kidney renal clear cell carcinoma (KIRC) represents one of the most fatal cancers, usually showing malignant progression and a high tumor recurrence rate. The urokinase-type plasminogen activator receptor (PLAUR) plays a critical role in the initiation and progression of several cancers, including KIRC. However, the function and mechanism of PLAUR in patients with KIRC are still unclear and require further investigation. In the present study, we first explored the expression profile and prognostic values of PLAUR in pan-cancer based on The Cancer Genome Atlas and Genotype-Tissue Expression databases. PLAUR was upregulated in multiple cancers and was significantly associated with poor overall survival and disease-free survival only in patients with KIRC. Subsequently, the PVT1/SNHG15-hsa-miR-532-3p axis was identified as the most potential upstream regulatory network of PLAUR in KIRC. In addition, PLAUR expression was closely associated with tumor-infiltrating immune cells, tumor immunity biomarkers, and immunomodulator expression. Furthermore, we constructed a multiple-gene risk prediction signature according to the PLAUR-related immunomodulators (PRIs). A prognostic nomogram was then developed to predict the 1-, 3-, and 5-year survival probabilities of individuals. In conclusion, our study identified the PVT1/SNHG15-hsa-miR-532-3p-PLAUR axis and a prognostic signature of PRIs, which could be a reference for future clinical research.
Applications of diffusion tensor imaging integrated with neuronavigation to prevent visual damage during tumor resection in the optic radiation area
Authors: Shi Jianwei , Lu Dafeng , Pan Ruihan , Chen Hairong , Teng Hong , Xu Yang , Bo Fuduo , Zhou Qi , Zhang Yansong 
Published: August 2022

BackgroundIntracranial tumors involving the temporo-occipital lobe often compress or destroy the optic radiation (OpR), resulting in decreased visual function. The aim of this study is to explore the value of diffusion tensor imaging (DTI) tractography integrated with neuronavigation to prevent visual damage when resecting tumors involving the OpR and find potential factors affecting patients’ visual function and quality of life (QOL).MethodsOur study is a cross-sectional study that included 28 patients with intracranial tumors in close morphological relationship with the OpR recruited between January 2020 and February 2022. The surgical incision and approach were preoperatively designed and adjusted according to the DTI tractography results and visual function scores. All patients underwent examinations of visual acuity (VA) and visual field index (VFI) and completed visual function and QOL scales at admission and 2 months after discharge. Logistic regression and linear regression analysis were conducted to evaluate clinical factors potentially affecting pre/postoperative OpR morphology, VA, VFI, visual function, and QOL.ResultsLesion size was the main factor found to affect visual function (β = -0.74, 95%CI: -1.12~-0.36, P = 0.05), VA (left: β = -0.11, 95%CI: -0.14~-0.08, P &lt; 0.001; right: β = -0.15, 95%CI: -0.17~-0.13, P &lt; 0.001), and VFI (left: β = -0.11, 95%CI: -0.14~-0.08, P &lt; 0.001; right: β = -0.14, 95%CI: -0.16~-0.12, P &lt; 0.001). Lesion size, edema, and involvement of the lateral ventricle temporal horn were factors affecting OpR morphology and QOL. The 28 patients showed significantly improved VA, VFI, visual function, and QOL results (P &lt; 0.05) 2 months after discharge.ConclusionsCombining DTI of OpR mapping and microscopic-based neuronavigation aided precise mapping and thus preservation of visual function in patients undergoing tumor resection. Potential clinical factors affecting patients’ visual function and QOL scores were identified which are useful for assessing a patient’s condition and predicting prognosis.