bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of body mass index and its relationship with breast cancer survival in a clinical oncology service in the Federal District
Authors: Ferreira Kamila Fernandes , Weis Luiza Nardin , Assunção Leandro Almeida , Oliveira Eduarda Sabá Cordeiro de , Castro Rafael Amaral de 
Published: October 2022

ABSTRACT
Objective: The purpose of this study was to analyze the relationship between obesity and clinical outcomes in breast cancer patients by evaluating the mean body mass index (BMI) and overall survival.
Material and Methods: The research's method consisted of a retrospective observational and descriptive study without intervention, carried out in a public oncology service in Brazils Federal District. We selected breast cancer patients with hormonal expression positivity in follow-up from January 2016 to December 2020.
Results: 305 female patients were evaluated, aged between 33 and 92 years old (average age of 59). Most patients were over 55 years old (63.3%). The mean weight of the patients was 71.70±9.10 kilograms. Regarding BMI, 38.7% of patients were classified as obese. As for the immunohistochemical classification (IHC), 72.9% of the patients were luminal B. Among the patients in which the initial treatment was registered, 56.1% received hormone therapy, while 43.9% received chemotherapy. The intention to treat in most patients was curative. Most patients had disease staging between II and III. As for the outcome, most patients were still undergoing treatment (83.0%) at the time of data collection. Correlating the IHC classification with patient survival, there was no significant difference between patient's classified as luminal A and those classified as luminal B (p: 0.342). There was also no significant difference between non-obese and obese patients in the assessment of overall survival and weight (p: 0.917).
Conclusion: Despite the high prevalence of obesity in the studied population, the overall survival of this group did not differ from the non-obese group, even in the analyzes by IHC profile.
Reseña. Iberia vaciada. Despoblación, decrecimiento, colapso
Authors: Henkel Hannah , Pla-Bañuls Jaume 
Published: October 2022

Resumen: En la obra reseñada el autor, Carlos Taibo, describe las realidades sociodemográficas de las zonas rurales de la Península Ibérica, dando además lugar a una discusión sobre el modelo económico protagonista de las mismas, el cual nos lleva hacia el colapso ambiental de nuestras sociedades. Ante esta situación, el autor plantea una serie de actuaciones necesarias para garantizar que la sociedad pueda hacer frente al colapso, siempre desde la mirada del decrecimiento y la ruptura del sistema actual (y que presenta alrededor de cuatro herramientas conceptuales, a saber: “preservación”, “recuperación”, “introducción” y “rechazo”). Y aunque algunas conceptualizaciones nos resulten un tanto tradicionales o limitadas (como ocurre al tratar la perspectiva de género), la lectura de este libro resulta novedosa debido a la constante opinión crítica del autor a lo largo del libro, en donde propone ciertas ideas que pretenden romper de forma radical con la situación o realidad actual, dejando con urgencia el capitalismo (desde nuestro punto de vista, algo que en función de nuestra interconexión global constante e instantánea resulta, hoy por hoy, relativamente utópico).

Palabras clave: colapso, decrecimiento, despoblación, neorruralidad, Iberia vaciada.
Reseña. Cómo hacer click hacia una nueva economía. Una revolución circular con el ser humano en el centro
Authors: García García María Del Mar 
Published: October 2022

Resumen: En la obra reseñada se presenta la economía circular como la herramienta que puede permitirnos cambiar el rumbo de nuestro actual modelo y sistema económico, con el objetivo de encontrar un mayor equilibrio entre nuestros recursos ambientales y humanos. O en palabras de su autor, Luis Lehmann, “un camino de reactivación sostenible”, partiendo a su vez, del “concepto de responsabilidad aplicado al desarrollo económico” que tiene el ser humano como fuente y solución de los problemas.

Palabras clave: economía circular, cambio climático, sostenibilidad, revolución, ODS, empleo circular.
Proyecto de cooperación LEADER: CRE-A Rural. Red valenciana rural de emprendimiento
Authors: Asociación para la Sostenibilidad e Innovación Rural GAL 
Published: October 2022

Resumen: El proyecto “Red Valenciana Rural de Emprendimiento: CRE- A RURAL” es resultado de la cooperación establecida en el marco de la Medida 19 LEADER del Programa de Desarrollo Rural de la Comunidad Valenciana (PDR-CV) 2014-2020 entre la Asociación para la Sostenibilidad e Innovación Rural –ASIR, el GAL Rural Muntanya d’Alacant, RURABLE y el GAL Castellón Sur 14-20. Esta iniciativa de cooperación respondió a la necesidad de revertir la tendencia socio económica de los territorios rurales de la Comunidad Valenciana (despoblación, envejecimiento, elevada tasa de desempleo, pérdida de actividad, escaso dinamismo empresarial, etc.), agravada en la fase de pandemia mundial, fomentando iniciativas de forma conjunta para elevar el atractivo de la zona para atraer y retener a la población, así como para generar un ecosistema emprendedor que dinamice la economía rural. Para ello, se desarrollaron dos líneas de acción, una dirigida al diagnóstico con el que conocer experiencias previas sobre los factores que afectan a la toma de decisiones de emprendedores, profesionales y empresas a la hora de decidir instalarse en el espacio rural; y otra, enmarcada en un programa de mentorización en base a nuevos proyectos de emprendedores y empresas en el medio rural en base a criterios de sostenibilidad, innovación y de respuesta a necesidades u oportunidades de cada territorio. Los resultados del proyecto nos permiten considerar la continuidad de las líneas de trabajo iniciadas, actuando de forma complementaria, desde el ámbito territorial y en el del emprendimiento.

Palabras clave: espacios rurales, desarrollo territorial, despoblación, (auto)evaluación, mentorización.
Reseña. (In)Justicias urbanas, ciudades (In)justas. Políticas urbanas, mercantilización y turistificación en ciudades de América Latina y España
Authors: Iturrino-Guerrero Javier 
Published: October 2022

Resumen: La obra “(In)Justicias urbanas, ciudades (In)justas. Políticas urbanas, mercantilización y turistificación en ciudades de América Latina y España” reúne un conjunto de artículos científicos resultado de diferentes proyectos de investigación dictaminados por pares expertos de, principalmente, un amplio grupo de instituciones universitaria. Los diecisiete artículos se agrupan en tres bloques. El primero indaga sobre las ciudades (in)justas, las políticas públicas y los gobiernos locales. El segundo bloque muestra las tensiones producidas por la mercantilización de la ciudad, mientras que el último bloque pone ejemplos sobre los conflictos urbanos producto de la creciente actividad turística.

Palabras clave: derecho a la ciudad, movilidad urbana, turistificación urbana, municipalismo y políticas urbanas, neoliberalismo y mercantilización urbana.
Reseña. Estrategias, espacios y redes para la innovación urbana
Authors: Sánchez-Cabrera José Vicente 
Published: October 2022

Resumen: Los días 15 y 16 de octubre del año 2020, en el marco de los proyectos de investigación del Plan Nacional I+D+I “Atracción del talento, innovación y creatividad para el desarrollo inteligente de la ciudad-región de Madrid” y “Sostenibilidad social, conectividad global y economía creativa como estrategias de desarrollo en el Área Metropolitana de Valencia”, se celebró el seminario de investigación “Estrategias, espacios y redes para la innovación urbana”. Unas jornadas organizadas por la Universidad de Complutense de Madrid y el espacio de innovación ‘La Nave’ del Ayuntamiento de esta ciudad. La oportunidad del evento merece, sin lugar a dudas, la edición de un libro resumen de carácter colectivo. Reúne la contribución de diversos especialistas en torno al pasado reciente, presente y sobre todo el futuro que seguramente le espera a la innovación en las regiones y ciudades del siglo XXI. En realidad, se trata de una edición de bolsillo que recopila de forma sintética, la imposibilidad de desligar el macroconcepto de la innovación y la inteligencia, de otros factores espaciales y que normalmente se concretan en áreas metropolitanas y ahora también en el corazón de las ciudades. La obra se estructura a partir de una introducción inicial y un capítulo final de conclusiones, para dejar en su nudo una selección de casos focalizados en distintas ciudades que están planteando sus estrategias innovadoras. La publicación tampoco olvida seleccionar una colección de temáticas que son entendidas como clave, para la mejor comprensión del mundo y de la innovación en un contexto de crisis casi permanente. No hay que olvidar, según los autores, que la innovación surge con más facilidad en tiempos o coyunturas de máxima dificultad como es el actual. Una publicación que contextualiza los riesgos de no apostar, o de no contar con los necesarios procesos de innovación que marcan las oportunidades en una liga de ciudades mundial que pugnan por ser más sostenibles, competitivas y socialmente justas.

Palabras clave: innovación social, creatividad, startup, gobernanza, participación, solidaridad, ciudad, región, smart city, tecnología, inversión, capital humano, empresas, calidad de vida, clúster, economía, solución, creatividad, crisis, COVID.
Reseña. Innovación y sociedad
Authors: Bergua Jorge 
Published: October 2022

Resumen: Desde un enfoque sociológico se presenta una exploración de las opiniones, actitudes, capacidades y comportamientos innovadores de la población española: innovación (como cambio intencional basado en el conocimiento), valores, condiciones socioeconómicas y comportamientos agregados que pueden adoptarse y tener una extensión beneficiosa en el tejido social de un país. El estudio se construye a través de un análisis macrosocial y la metodología de encuesta mediante una entrevista personal, y busca ofrecer una base para explorar la situación en España.

Palabras clave: innovación; opiniones; actitudes; capacidad de acción; España.
The cloacal microbiome of a cavity-nesting raptor, the lesser kestrel (Falco naumanni)
Authors: Costanzo Alessandra , Ambrosini Roberto , Franzetti Andrea , Romano Andrea , Cecere Jacopo G. , Morganti Michelangelo , Rubolini Diego , Gandolfi Isabella 
Published: October 2022

Background
Microbial communities are found on any part of animal bodies exposed to the environment, and are particularly prominent in the gut, where they play such a major role in the host metabolism and physiology to be considered a “second genome”. These communities, collectively known as “microbiome”, are well studied in humans and model species, while studies on wild animals have lagged behind. This is unfortunate, as different studies suggested the central role of the gut microbiome in shaping the evolutionary trajectories of species and their population dynamics. Among bird species, only few descriptions of raptor gut microbiomes are available, and mainly carried out on captive individuals.

Objectives
In this study, we aimed at improving the knowledge of raptor microbiomes by providing the first description of the gut microbiome of the lesser kestrel (Falco naumanni), a cavity-nesting raptor.

Results
The gut microbiome of the lesser kestrel was dominated by Actinobacteria (83.9%), Proteobacteria (8.6%) and Firmicutes (4.3%). We detected no differences in microbiome composition between males and females. Furthermore, the general composition of the microbiome appears similar to that of phylogenetically distant cavity-nesting species.

Conclusions
Our results broaden the knowledge of raptor gut microbial communities and let us hypothesize that the distinct nest environment in terms of microclimate and presence of organic material from previous breeding attempts, to which cavity-nesting species that reuse the nest are exposed, might be an important driver shaping microbiomes.
The Male to Female Ratio in Treatment-Warranted Retinopathy of Prematurity
Authors: Hoyek Sandra , Peacker Bryan L. , Acaba-Berrocal Luis A. , Al-Khersan Hasenin , Zhao Yan , Hartnett Mary Elizabeth , Berrocal Audina M. , Patel Nimesh A. 
Published: October 2022

ImportanceLiterature and anecdotal evidence suggest a relationship between male sex and retinopathy of prematurity (ROP). It is not known whether a difference, if present, is sex-related pathophysiologic predisposition or sex difference in meeting ROP screening criteria.ObjectiveTo evaluate the association of sex with the development of treatment-warranted ROP.Data SourcesPubMed, Embase, and Web of Science databases were searched from 2000 to 2022. The search strategy used keywords including retinopathy of prematurity or ROP or retrolental fibroplasia and treatment or anti-VEGF or bevacizumab or ranibizumab or aflibercept or conbercept or laser or cryotherapy and gender or sex or male or female and medical subject headings terms.Study SelectionAll studies reporting on treatment with anti–vascular endothelial growth factor, laser photocoagulation, and/or cryotherapy for ROP were identified. Studies reporting sex distribution in the treatment group were included in the meta-analysis. Exclusion criteria included case reports, case series of fewer than 10 treated patients, systematic reviews, conference abstracts, letters to the editor, animal studies, and non-English records.Data Extraction and SynthesisTwo reviewers independently screened and extracted the data following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The proportions of treated male and female infants were combined using random-effects meta-analysis.Main Outcomes and MeasuresNumbers and percentages of male and female infants treated for ROP.ResultsOf 11 368 identified studies, 316 met inclusion criteria, yielding a total of 31 026 treated patients. A higher percentage of male infants were treated for ROP (55% [95% CI, 0.54%-0.55%]), with low heterogeneity between studies (I2 = 34%; P &amp;lt; .001). Thirty-eight studies reported sex distribution in the screened population (170 053 patients; 92 612 [53%] male vs 77 441 [47%] female). There was no significant difference in the odds of receiving treatment between screened male and female infants (pooled odds ratio, 1.04 [95% CI, 0.91-1.18]; P = .67).Conclusions and RelevanceMore male infants are treated for ROP than female infants. This could be due to a known relative pathophysiological fragility of preterm male infants in addition to a difference in ROP screening rates, with more male infants meeting the criteria than female infants. These findings have implications for future studies and may prompt more careful clinical monitoring of male neonates.
Impact of heat generation and use of experimental instruments in a fume hood on pollutant capture efficiency
Authors: Muta Ryota , Ito Kazuhide 
Published: October 2022

AbstractA fume hood is a local ventilation system that is typically installed in a laboratory space to ensure the safety of workers from chemical exposure. A fume hood is designed to capture hazardous gas‐phase pollutants generated inside a box‐like enclosure, and the pollutant capture efficiency is regulated by the average opening surface air velocity. However, few cases exist in which the pollutant capture efficiency inside the fume hood is precisely analyzed and quantitatively visualized. In this study, the capture performance of a fume hood under actual use conditions was evaluated using computational fluid dynamics (CFD). The factors that could affect the performance, that is, the exhaust airflow rate, experimental instruments inside, worker in front, and heat source within the fume hood, were parametrically considered. The numerical analyses revealed that experimental instruments near the opening surface significantly affected the airflow into the fume hood and decreased its capture performance. Under the inadequate condition of a low exhaust airflow rate, pollutant leakage inside the chamber was observed due to the presence of a worker in front of the fume hood and the heat source inside. Furthermore, the pollutant capture performance was slightly improved by changing the layout/position of the experimental instrument.
Architectural characteristics and management of group homes for persons with disabilities
Authors: Matsuda Yuji , Tobimatsu Taketo , Fujii Risa 
Published: October 2022

AbstractJapan's group homes, where usually three to seven people with disabilities live in a community residence, are gradually increasing in number as a residence for persons with disabilities. However, it remains unclear what challenges exist in opening and operating such homes, and how the challenges differ depending on the type of resident disability. A questionnaire survey was administered among corporations operating group homes for persons with disabilities (GHD) in Japan's Kanto region regarding issues during opening and operation of GHDs, as well as the condition of the buildings. The results revealed the following issues. First, in metropolitan areas such as Tokyo, it is difficult to construct or lease a building with sufficient space. Second, GHDs, where people with intellectual disabilities live, are often positioned as permanent residences. Furthermore, in GHDs where the residents primarily have physically disabilities, it is often difficult to achieve sufficient floor space. In addition, in GHDs primarily housing people with mental disabilities, they are often positioned as temporary residences prior to living alone in apartments, etc., and understanding from neighborhood residents constitutes a major issue.
Rhodium‐Catalyzed CH Functionalization to Construct Annulated Molecules
Authors: Mahato Sujit , Sarkar Writhabrata , Naskar Koushik , Deb Indubhusan 
Published: October 2022

Abstract

Rhodium complexes are exceptionally significant in homogeneous catalysis. The synthetic community observed the rapid burgeoning of such rhodium catalysis since the discovery of Wilkinson's catalyst. Rhodium‐catalyzed tandem C(sp
2
)H/C(sp
3
)H activation and annulation with alkenes, alkynes, arenes, and other reactive partners is a rapidly growing research field to obtain a new class of heterocycles and thereby generates potential biologically active pharmacophores. Superior reactivity of rhodium catalysts is attributed due to its good π‐acceptor character that favors the CH bond activation reaction of substrates containing a wide range of directing groups, such as amides, imines, carboxylic acid (derivatives), benzylic alcohols, ketones, various heterocycles and shown efficiency toward annulation reaction with various befitting partners; even undirected CH activations have also been achieved. This article provides a brief account of the recent developments in rhodium‐catalyzed CH activation/annulation reactions for the synthesis of new classes of fused cyclic scaffolds using suitable coupling partners. For the rhodium‐catalyzed annulation strategies, different types of cyclization reactions, namely, oxidative, redox‐neutral, photoredox, electrochemical reactions are discussed. In addition, the enantioselective synthesis of annulated molecules using chiral rhodium catalysts has also been highlighted.
Green Solvents for CH Functionalization
Authors: Santoro Stefano , Brufani Giulia , Rossini Gabriele , Vaccaro Luigi 
Published: October 2022

Abstract
Organic solvents are ubiquitous in most of the synthetic processes and play a crucial role in influencing the chemical behavior of catalytic system and/or reactive species. Modern chemistry inevitably includes an evaluation of the chemical efficiency and the environmental impact of a desired procedure. CH functionalization processes represent an important advance in terms of chemical efficiency to form new CC and CX bonds, and also for this type of transformation there is a great deal of interest for the use of safer/greener solvents that could replace the classic toxic ones. In this article, the current state of the art on the use of greener solvents as media for accessing chemically and environmentally efficient protocols for CH functionalization processes is summarized.
Manganese‐Catalyzed Regioselective CH Allylation, Allenylation, Halogenation, Dehydrogenative Annulation, and Amidation
Authors: Parmar Diksha , Sharma Upendra 
Published: October 2022

Abstract
In recent years, CH bond activation/functionalization directed by noble transition metals has arisen as a versatile platform in organic synthesis. Second‐row transition metals such as ruthenium, rhodium, and palladium have shown exceptional potential. However, due to the reasonably high prices of these noble transition metals, developing economic and earth‐abundant first‐row transition metals as alternate catalysts is appealing. In this context, manganese‐based catalysts are promising, considering the abundance of manganese in the earth's crust. In addition, manganese is a vital nutrient in all living beings and also presents as a cofactor in a range of enzymes, including oxidoreductases, transferases, and hydrolases, thus implying that it is safe to use. In this article, manganese‐catalyzed CH functionalization, including allylation, allenylation, halogenation, dehydrogenative annulation, and amidation through CH activation reported since 2016, has been summarized, with major emphasis on the mechanistic aspects. Few examples on manganese‐catalyzed annulations reported in 2014 and 2015 have also been discussed.
Asymmetric Alkene Hydroarylation via CH Functionalization
Authors: Wang Zi‐Chao , Shi Shi‐Liang 
Published: October 2022

Abstract
Asymmetric alkene hydroarylation through aromatic CH functionalization constitutes one of the most direct methods for the preparation of enantioenriched alkylated arenes. These reactions have many advantageous features, such as excellent atom‐, step‐, and redox‐economy, using simple feedstock chemicals, and without the generation of by‐products. We herein summarize recent advances in transition metal‐catalyzed enantioselective alkene hydroarylation via CH functionalization.
Chiral Cyclopentadienyl Ligand for Asymmetric CH Activation
Authors: Sun Jiaqiong , Zheng Guangfan 
Published: October 2022

Abstract

Asymmetric CH activation is a highly efficient and practical synthetic methodology for the direct construction of value‐added chiral organic molecular from simple starting materials. The chiral cyclopentadienyl ligand and its analogs are of great significance in asymmetric catalysis. Since the pioneering work by Cramer and Rovis, numerous efforts have been achieved in the design and synthesis of novel chiral cyclopentadienyl (Cp
X
) ligands as well as their metal complexes, which cause eruptive development of Cp
X
M‐catalyzed asymmetric CH functionalization. This article highlights the recent significant progress in the realm of direct and convenient creation of chiral elements via chiral Cp
X
M complex‐catalyzed CH functionalization, including the creation of central chirality (carbon and heteroatom central chirality), axial chirality, planar chirality, and helical chirality.