bluuebunny/crossref_metadata_2025_split huggingface dataset:
NaSICON: A promising solid electrolyte for solid‐state sodium batteries
Authors: Li Chi , Li Rui , Liu Kaining , Si Rui , Zhang Zhizhen , Hu Yong‐Sheng 
Published: July 2022

AbstractA surge of interest has been brought to all‐solid‐state batteries (ASSBs) as they show great prospects for enabling higher energy density and improved safety compared to conventional liquid batteries. Na Super Ionic CONductors (NaSICONs) proposed by Goodenough and Hong in 1976 are the most promising materials class for Na‐based ASSBs owing to their excellent ion conductivity (>1 mS cm−1), high thermal and chemical/electrochemical stability, as well as good chemical/electrochemical compatibility with electrode materials. The major challenge facing NaSICON‐type electrolytes is the generally high interfacial resistance and thus sluggish charge transfer kinetics across the NaSICON/cathode interface. Great endeavors in the past few years have led to progress in the improvement of the ion‐conducting property, and a dramatic decrease in the NaSICON/electrode interface resistance. Excellent cycling performance and rate capability have been achieved through interface engineering. In this review article, we summarize the state‐of‐the‐art findings for various derivatives of NaSICON structured solid electrolytes, with the aim of providing a deeper understanding of the underlying mechanism for the improvement of ion conductivity, and the intrinsic reasons for the enhanced interface charge transfer kinetics. These strategies can be readily extended to other solid electrolytes. We hope this review will inspire more work on NaSICON‐type solid electrolytes and solid‐state batteries.
Versatile aza‐BODIPY‐based low‐bandgap conjugated small molecule for light harvesting and near‐infrared photodetection
Authors: Bhat Gurudutt , Kielar Marcin , Rao Haixia , Gholami Mahnaz D. , Mathers Isabel , Larin Astrid C. R. , Flanagan Thomas , Erdenebileg Enkhtur , Bruno Annalisa , Pannu Amandeep Singh , Fairfull‐Smith Kathryn E. , Izake Emad L. , Sah Pankaj , Lam Yeng Ming , Pandey Ajay K. , Sonar Prashant 
Published: July 2022

AbstractThe versatile nature of organic conjugated materials renders their flawless integration into a diverse family of optoelectronic devices with light‐harvesting, photodetection, or light‐emitting capabilities. Classes of materials that offer the possibilities of two or more distinct optoelectronic functions are particularly attractive as they enable smart applications while providing the benefits of the ease of fabrication using low‐cost processes. Here, we develop a novel, multi‐purpose conjugated small molecule by combining boron‐azadipyrromethene (aza‐BODIPY) as electron acceptor with triphenylamine (TPA) as end‐capping donor units. The implemented donor–acceptor–donor (D–A–D) configuration, in the form of TPA‐azaBODIPY‐TPA, preserves ideal charge transfer characteristics with appropriate excitation energy levels, with the additional ability to be used as either a charge transporting interlayer or light‐sensing semiconducting layer in optoelectronic devices. To demonstrate its versatility, we first show that TPA‐azaBODIPY‐TPA can act as an excellent hole transport layer in methylammonium lead triiodide (MAPbI3)‐based perovskite solar cells with measured power conversion efficiencies exceeding 17%, outperforming control solar cells with PEDOT:PSS by nearly 60%. Furthermore, the optical bandgap of 1.49 eV is shown to provide significant photodetection in the wavelength range of up to 800 nm where TPA‐azaBODIPY‐TPA functions as donor in near‐infrared organic photodetectors (OPDs) composed of fullerene derivatives. Overall, the established versatility of TPA‐azaBODIPY‐TPA, combined with its robust thermal stability as well as excellent solubility and processability, provides a new guide for developing highly efficient multi‐purpose electronic materials for the next‐generation of smart optoelectronic devices.image
Higher Testosterone Dose Impairs Sperm Suppression Induced by a Combined Androgen‐Progestin Regimen
Authors: MERIGGIOLA M. CRISTINA , COSTANTINO ANTONIETTA , BREMNER WILLIAM J. , MORSELLI‐LABATE ANTONIO M. 
Published: July 2022

ABSTRACTIn this study we compared the effects of high‐dose and low‐dose testosterone enanthate (TE) administered with the same dose of cyproterone acetate (CPA). Eighteen men aged 21–45 were treated with CPA 5 mg/day and with TE 100 mg/week (n = 9; CPA‐5–100) or TE 200 mg/week (n = 9; CPA‐5–200) for 16 weeks. Semen analyses were performed every 2 weeks; physical examination and chemistry, hematology, gonadotropin, and testosterone measurements were performed every 4 weeks. At week 16 of treatment, sperm counts were significantly more suppressed in the CPA‐5–100 group than in the CPA‐5–200 group. Sperm counts returned to baseline in all subjects after hormone administration ceased. No difference in gonadotropin levels was found at any time between the 2 groups. During the treatment phase, testosterone levels were significantly higher in the CPA‐5–200 group than in the CPA‐5–100 group. The present study confirms that CPA/TE administration induces profound sperm suppression. An increase in the dose of androgen resulted in less profound sperm suppression despite no difference in gonadotropin suppression. These data suggest that high testosterone levels can maintain sperm production in men.
Realgar‐induced nephrotoxicity via ferroptosis in mice
Authors: Zhang Sheng , Cao Shuai , Zhou Heng , Li Limin , Hu Qing , Mao Xiuhong , Ji Shen 
Published: July 2022

AbstractFerroptosis is a novel form of iron‐dependent cell death that is involved in arsenic‐induced toxicity. Realgar is an arsenic‐containing Chinese medicine, which can result in nephrotoxicity because of long‐term exposure. However, it remains scientifically unknown whether Realgar is an inducer of ferroptosis in the kidney. This study investigated the role of ferroptosis in Realgar‐induced kidney toxicity in mice. ICR mice were exposed to Realgar for 28 days, and HK2 cells were exposed to Realgar in the presence or absence of treatment with ferrostatin‐1, a ferroptosis inhibitor. The ferroptosis‐related indicators were further evaluated. Realgar can cause nephrotoxicity in mice by continuous gavage for 28 days, accompanied by an increase in iron accumulation and reactive oxygen species (ROS). The reduced expression of Slc7A11 and Gpx4 further confirmed the ferroptosis mediated by Realgar. Meanwhile, Realgar disrupted the antioxidant system as evidenced by the formation of ROS leading to the inactivation of antioxidant enzymes. Realgar caused ferroptosis in a dose‐dependent manner, which was significantly reduced by ferrostatin‐1 in HK2 cells. This study revealed that Realgar‐induced ferroptosis triggered nephrotoxicity in mice and provided new clues to elucidate the mechanism of Realgar‐induced nephrotoxicity.
A review on preparation, surface enhancement and adsorption mechanism of biochar‐supported nano zero‐valent iron adsorbent for hazardous heavy metals
Authors: Awang Nor Asikin , Wan Salleh Wan Norharyati , Aziz Farhana , Yusof Norhaniza , Ismail Ahmad Fauzi 
Published: July 2022

AbstractHeavy metal pollution of water is a global concern, which adversely affects human health because of its resistance to biodegradation and thus its transmission in the food chain via bioaccumulation. Nano zerovalent iron (nZVI) is very effective for the removal of heavy metals and is cost effective in terms of production. However, the main problems of nZVI are agglomeration and ease of oxidation. Several stabilization materials have been implemented to limit the aggregation of nZVI, such as silica, activated carbon and biochar. In comparison, as a support material, biochar possesses a large surface area, high stability and strong adsorption capacity, as well as being obtainable from various types of materials. Thus, this work aims to establish the opportunities available on the use of biochar‐supported nZVI in utilizing its ability to stabilize and immobilize the nZVI. This review also reports the preparation, modification and surface enhancement of biochar, nZVI and biochar‐nZVI for practical use as adsorbents. This review shows that modifications of the nZVI surface can help in their stabilization and reduction of aggregation. Additionally, this review is able to increase one's understanding of heavy metal sorption behavior by biochar‐supported nZVI as it is the important as heavy metal sorption is driven based on biochar‐nZVI type and heavy metal species which involve numerous mechanisms, including physical binding, complexation, ion exchange, surface precipitation and electrostatic interactions. Furthermore, this research reviews the adsorption parameters, including the crucial adsorption mechanism of heavy metals onto biochar‐nZVI; the reusability of the biochar‐nZVI is also discussed in this work. © 2022 Society of Chemical Industry (SCI).
Quantification of geogenic carbon in anthropogenic alluvial coal soils of the Susquehanna River
Authors: Williams Elizabeth K. , Ricker Matthew C. , Plante Alain F. 
Published: July 2022

AbstractAlluvial riparian soils act as a filtration system, improving the environmental quality of downstream soils and waters. In areas affected by coal mining, alluvial soils also serve as a modern “sink” of fossil carbon (C). To date, little research has been done on ecosystem services provided by alluvial landscapes (i.e., river islands and tributary deltas) in the retention of coal in coal‐mining regions. The objective of this study was to distinguish between and quantify geogenic and neogenetic C in alluvial soils of the North Branch of the Susquehanna River (NBSR). To investigate this, we compared five thermal analysis methods to quantify geogenic (coal) C in soils. Our results indicate that multivariate curve resolution of ramped thermal combustion data provided the most accurate estimate of coal content in soils. Our analysis found that NBSR alluvial soils have accumulated ∼375 Gg of anthropogenic, geogenic C (upper 1 m). In these soils, an average of ∼11% of soil mass is attributable to coal, yet ∼73% of the total soil C is attributable to geogenic C. These soil organic C stocks are substantially greater than locally mapped riparian soils unaffected by coal mining and are greater than regional organic soils (Histosols). Quantification of microbial decomposition of coal in alluvial soils and vulnerability to extreme flood events (potential remobilization) requires further investigation and will be important in determining the fate of this C sink.
Longitudinal follow‐up of HPV16 sequence after cervical infection: Low intrahost variation and no correlation with clinical evolution
Authors: Debernardi Alice , Valot Benoit , Almarcha Julien , Guenat David , Hocquet Didier , Algros Marie‐Paule , Riethmuller Didier , Ramanah Rajeev , Mougin Christiane , Prétet Jean‐Luc , Lepiller Quentin 
Published: July 2022

AbstractHuman papillomavirus (HPV) 16 exhibits different variants that may differ in their carcinogenic risk. To identify some high‐risk variants, we sequenced and compared HPV16 whole genomes obtained from a longitudinal cohort of 34 HPV16‐infected women who had either spontaneously cleared their infection (clearance group or “C”), or developed cervical high‐grade lesions following a viral persistence (group persistence or “P”). Phylogenetic analysis of paired samples obtained at the beginning (C0 or P0) and at the end (C2 or P2) of the follow‐up (median intervals between C0–C2 and between P0–P2 were 16 and 36.5 months, respectively) revealed a low genetic variability within the host compared to the genetic interhost diversity. By comparing our HPV16 sequences to a reference sequence, we observed 301 different substitutions, more often transitions (60.9%) than transversions (39.1%), that occurred throughout the viral genome, but with a low frequency in E6 and E7 oncogenes (10 and 9 substitutions), suggesting a high conservation of these genes. Deletions and insertions were mostly observed in intergenic regions of the virus. The only significant substitution found between the subgroups C2 and P2 was observed in the L2 gene (L330F), with an unclear biological relevance. Our results suggest a low longitudinal intrahost evolution of HPV16 sequences and no correlation between genetic variations and clinical evolution.
The variant‐specific burden of SARS‐CoV‐2 in Michigan: March 2020 through November 2021
Authors: Petrie Joshua G. , Eisenberg Marisa C. , Lauring Adam S. , Gilbert Julie , Harrison Samantha M. , DeJonge Peter M. , Martin Emily T. 
Published: July 2022

AbstractAccurate estimates of the total burden of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are needed to inform policy, planning, and response. We sought to quantify SARS‐CoV‐2 cases, hospitalizations, and deaths by age in Michigan. Coronavirus disease 2019 cases reported to the Michigan Disease Surveillance System were multiplied by age and time‐specific adjustment factors to correct for under‐detection. Adjustment factors were estimated in a model fit to incidence data and seroprevalence estimates. Age‐specific incidence of SARS‐CoV‐2 hospitalization, death, vaccination, and variant proportions were estimated from publicly available data. We estimated substantial under‐detection of infection that varied by age and time. Accounting for under‐detection, we estimate the cumulative incidence of infection in Michigan reached 75% by mid‐November 2021, and over 87% of Michigan residents were estimated to have had ≥1 vaccination dose and/or previous infection. Comparing pandemic waves, the relative burden among children increased over time. In general, the proportion of cases who were hospitalized or who died decreased over time. Our results highlight the ongoing risk of periods of high SARS‐CoV‐2 incidence despite widespread prior infection and vaccination. This underscores the need for long‐term planning for surveillance, vaccination, and other mitigation measures amidst continued response to the acute pandemic.
Reconstruction of oral cavity defects using myogenous‐only scapular tip free‐flaps
Authors: Barton Blair M. , Pappa Andrew K. , Blumberg Jeffrey , Patel Samip 
Published: July 2022

AbstractBackgroundOral cavity reconstruction is very challenging anatomical subsite to reconstruct. Large defects often require free tissue reconstruction to provide the best chance of form and function. Additionally, free tissue reconstruction aids to prevent fistula formation. We aimed to determine outcomes of oral cavity defect reconstruction using scapular tip free flaps with a myogenous intraoral component.MethodsAll patients with a mandibular or maxillary bony defect that included a disruption of the intraoral mucosa component between 07/1/14 and 07/31/17. Patients were reconstructed with a scapular tip free flap, which included a muscular component that was used to recreate the oral mucosa. The primary study outcomes were flap success rates, development of orocutaneous or oronasal fistula, rate of resuming oral diet as well as the occurrence of medical and surgical complications in the first month following surgery. The tested hypothesis was formulated before data collection began.ResultsTwenty‐five patients were identified by the study criteria. There was one (4%) flap that failed, while orocutaneous fistula occurred in two patients (8%). Prior history of osteoradionecrosis was a statistically significant predictor of overall complication (p < .05).ConclusionsIntraoral myogenous reconstruction allows for re‐mucosalization of the oral cavity defect and is associated with high viability and low‐complication rates. In patients with amenable oral mucosal defects, a myogenous scapular tip free flap is a suitable reconstructive option.
2D FEM simulation and experimental verification of Al 7075‐T6 during turning process
Authors: Mohan Kumar A. , Rajasekar R. , Parameshwaran R. 
Published: July 2022

AbstractIn this work, temperature distribution, effective stress and strain distribution in Al 7075‐T6 material and plastic flow of materials during turning process have been studied using Deform 3D v11.0 software. The four different points (P1, P2, P3, and P4) were chosen at the different locations in the cylindrical workpiece and the graph has been plotted with different parameters namely, temperature distribution, effective stress and strain. For temperature distribution, a good agreement has been found between simulation and experimental results at P4. The following results obtained from the simulation: In tertiary zone, the maximum temperature of specimen reaches upto 142 °C at points P1 due to friction between the tool rack face and the lower surface of chip. Maximum effective stress value reaches upto 650 MPa and 704 MPa at P1 and P4 respectively in the first sticking zone due to the combined effect of high normal force by tool edge and ploughing force. The effective strain value at P1 and P4 obtained, strain at P4 reaches maximum compare to P1 due to friction and unven temperature distribution. Additionally, chip analysis has been performed with microscopic image.
Metallic surface architectures realized through plastically deformed micro‐volumes
Authors: Raducanu D. , Cojocaru V.D. , Raducanu V.A. , Cojocaru M.E. , Nocivin A. , Irimescu R.E. , Galbinasu B.M. 
Published: July 2022

AbstractFor developing performing medical devices, the biomechanical adaptation plays a key role for both, the bulk material (at macro scale) and surfaces (at micro/nano scale). As concerning the interaction of living cells with artificial surfaces, the cellular mechano‐sensitivity has direct effects on tissue structure and functions. In this work, surfaces architectures, obtained by self‐nano‐crystallization, were realized on a gum‐alloy as substrate (titanium‐niobium‐zirconium‐iron‐oxygen), using silicone masks with micrometric patterns/perforations, on which a near‐surface‐severe‐plastic‐deformation process was applied. For finding 3D suitable geometries of the perforations and their distribution on the masks, generative design algorithms were developed using dedicated software tools. The masks were obtained by 3D printing using the fused filament fabrication method. Multidirectional repeated mechanical impacts on the sample surface with high velocity balls at high strain rates were applied. Deeper compressive residual stresses are generated, creating a superficial self‐nano‐crystallized structure on un‐covered areas, due to small volume‐multidirectional local plastic deformation. The applied parameters have a direct effect on local micro‐topography and microstructure evolution.
RNA‐sequencing reveals genes linked with oocyte developmental potential in bovine cumulus cells
Authors: Martínez‐Moro Álvaro , González‐Brusi Leopoldo , Lamas‐Toranzo Ismael , O'Callaghan Elena , Esteve‐Codina Anna , Lonergan Pat , Bermejo‐Álvarez Pablo 
Published: July 2022

AbstractCumulus cells provide an interesting biological material to perform analyses to understand the molecular clues determining oocyte competence. The objective of this study was to analyze the transcriptional differences between cumulus cells from oocytes exhibiting different developmental potentials following individual in vitro embryo production by RNA‐seq. Cumulus cells were allocated into three groups according to the developmental potential of the oocyte following fertilization: (1) oocytes developing to blastocysts (Bl+), (2) oocytes cleaving but arresting development before the blastocyst stage (Bl−), and (3) oocytes not cleaving (Cl−). RNAseq was performed on 4 (Cl−) or 5 samples (Bl+ and Bl−) of cumulus cells pooled from 10 cumulus‐oocyte complexes per group. A total of 49, 50, and 18 differentially expressed genes (DEGs) were detected in the comparisons Bl+ versus Bl−, Bl+ versus Cl− and Bl‐ versus Cl−, respectively, showing a fold change greater than 1.5 at an adjusted p value <0.05. Focussing on DEGs in cumulus cells from Bl+ group, 10 DEGs were common to both comparisons (10/49 from Bl+ vs. Bl−, 10/50 from Bl+ vs. Cl−). These DEGs correspond to 6 upregulated genes (HBE1, ITGA1, PAPPA, AKAP12, ITGA5, and SLC1A4), and 4 downregulated genes (GSTA1, PSMB8, FMOD, and SFRP4) in Bl+ compared to the other groups, from which 7 were validated by quantitative PCR (HBE1, ITGA1, PAPPA, AKAP12, ITGA5, PSMB8 and SFRP4). These genes are involved in critical biological functions such as integrin‐mediated cell adhesion, oxygen availability, IGF and Wnt signaling or PKA pathway, highlighting specific biological processes altered in incompetent in vitro maturation oocytes.
Long‐term treatment effects of inotersen on health‐related quality of life in patients with hATTR amyloidosis with polyneuropathy: Analysis of the open‐label extension of the NEURO‐TTR trial
Authors: Karam Chafic , Brown Duncan , Yang Min , Done Nicolae , Zhu Jing Jing , Greatsinger Alexandra , Bozas Ana , Vera‐Llonch Montserrat , Signorovitch James 
Published: July 2022

AbstractIntroduction/AimsHereditary transthyretin‐mediated amyloidosis with polyneuropathy (hATTR‐PN) progressively affects patients' functionality and compromises health‐related quality of life (HRQL). The aim of this study was to quantify the projected long‐term treatment effects of inotersen vs placebo on HRQL measures.MethodsThe inotersen phase 2/3 randomized, double‐blind, placebo‐controlled trial NEURO‐TTR (NCT01737398, 65 weeks) and its subsequent open‐label extension (OLE; NCT02175004, 104 weeks) included 172 (112 inotersen and 60 placebo) patients. Placebo double‐blind period and overall inotersen‐inotersen (double‐blind/OLE) treatment period (170 weeks) data were used to extrapolate the long‐term placebo‐placebo effect using mixed‐effects models with repeated measures. Changes from baseline in the Norfolk Quality of Life‐Diabetic Neuropathy (QoL‐DN) and 36‐Item Short Form Health Survey version 2 (SF‐36v2) in hATTR‐PN were estimated. Differences in changes were compared between the inotersen‐inotersen and extrapolated placebo‐placebo arms.ResultsInotersen‐inotersen patients maintained their HRQL with an observed change ranging from 10.3% improvement (Norfolk QoL‐DN item “Pain kept you awake at night”) to 11.6% deterioration (SF‐36v2 Activities of Daily Living subdomain). The extrapolated placebo‐placebo results suggest greater deterioration over time compared with inotersen‐inotersen treatment on Norfolk QoL‐DN total score (23.6; 95% confidence interval [CI], 8.9‐38.3; P < .01), Activities of Daily Living (4.6; 95% CI, 2.0‐7.3; P < .001), and “Pain kept you awake at night” (1.2; 95% CI, 0.4‐1.9; P < .01). Similarly, greater deterioration was expected for the SF‐36v2 Physical Component Summary (8.0; 95% CI, 3.2‐12.8, P < .01), Bodily Pain (7.8; 95% CI, 2.0‐13.5; P < .01), and Physical Functioning (10.6; 95% CI, 5.5‐15.6; P < .0001).DiscussionLong‐term (>3 years) inotersen treatment was associated with slowing and, in some domains, halting of deterioration in key HRQL outcome measures, particularly physical functioning and pain.