bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental Bonding and College Freshmen’s Depression Symptoms in China: The Mediating Role of Neuroticism
Authors: Yu Tengxu , Hu Jinsheng , Zhang Longfei 
Published: February 2022

Abstract
Background: This study aims to examine the influence of parental bonding on depression symptoms and the mediating role of neuroticism in their association among college freshmen. Methods: A sample of 2636 first-year college students from a university in Liaoning province, China were recruited. The care and control subscales of Parental Bonding Instrument (PBI), Beck Depression Inventory-II (BDI–Ⅱ), and the neuroticism scale of Eysenck Personality Questionnaire (EPQ) were used to measure parental bonding, depression symptoms, and neuroticism, respectively. Results: Structural equation models indicated that maternal or paternal care negatively predicted depression symptoms, while maternal control had a significant and positive prediction of depression symptoms. Additionally, the interaction effects between care and control from both mothers and fathers on depression symptoms were also significant. The negative predictive effects of parental (maternal or paternal) care on depression symptoms were greater when parental (maternal or paternal) control was at a high level. Finally, neuroticism partially mediated the relationships between maternal care or control and depressive symptoms, paternal care and depressive symptoms; while served as a full mediator in the association between paternal control and depression symptoms. Conclusion: Parental bonding can directly affect college freshmen’s depression symptoms, and have indirect effects via the mediating role of neuroticism. These results may advance our understanding of the influence of family environment on college freshmen’s depression symptoms and its mechanisms.
Returning to the Simplest Way: Clinical Results of Patients Undergoing Ivf in Natural Vs Modified Natural Cycles
Authors: Lopez Enrique Garcia , Calzada Alfonso Bermejo de la , Cabada Nereida Galajares , Martin Barbara Castro 
Published: February 2022

Abstract
Background
In recent years, natural cycle IVF has been undergoing a revival, gaining recognition as a safer, cheaper, and more comfortable option for patients. we define natural cicle IVF as the treatment in which oocytes are obtained from a spontaneous ovulatory cycle. When oral drugs are used (usually clomiphene citrate or letrozole), the process is referred to as modified natural cycle IVF. The aim of this study is to clarify whether the introduction of oral medication is beneficial for patients.
Methods
We retrospectively analysed all natural or modified IVF treatments that took place in our clinic during the studied period (January 2016 - December 2020). Descriptive variables were analysed with a t-test, and a chi-square test was performed on result variables.
Results
We found significant differences in the number of oocytes obtained after oocyte retrieval was (1.03 vs 1.63, p<0.001), number of mature oocytes (0.9 vs 1.3, p < 0.01), fertilization rate (0.7 vs 1.1, p < 0.01), and number of embryos available for transfer (0.5 vs 0.7, p < 0.01).However, we did not found signficant differences in terms of pregnancy rate (26,3% vs 19,6%, p=0.251) or live birth rate (16.3% vs 14,3%, p=0.7806)
Conclusions
although the numbers of oocytes and embryos available were higher in the group that used oral medication (which is similar to that obtained in previous studies), we did not find any differences in success rates in terms of pregnancy or live birth rate. Adding oral medication to natural cycle IVF, although reducing cancellation rates, does not seem to have an impact on the clinical results of the cycle. More studies are necessary, but we could reconsider the need to add oral medication since they suppose a higher cost for the patient.
Detection of Lysosomal Acid Lipase Deficiency in Tertiary Referral Centres
Authors: Kwok See , Soran Handrean , Barr Marianne 
Published: February 2022

Abstract
BackgroundLysosomal acid lipase deficiency (LALD) is a rare autosomal recessive metabolic disorder. Mutations in the LIPA gene that encodes LAL result in disrupted triglyceride metabolism. Presentations and severity of the disorder are diverse and are often non-specific. Characterisations of LALD include dyslipidaemia and abnormal liver function which can overlap with conditions such as familial hypercholesterolaemia and non-alcoholic fatty liver disease (NAFLD). The rarity of LALD may mean that the condition is unrecognised or misdiagnosed. The development of effective enzyme replacement therapy for LALD has provided motivation for identifying the condition clinically. Diagnosis of LALD by genetic testing is costly. However the relatively inexpensive assay of LAL activity in dried blood spot (DBS) has made the diagnosis of LALD in clinical practice more available. We studied LALD screening in 3 cohorts: patients from hospital Lipid and Diabetes Clinics selected using the current recommended criteria,1 patients from hospital Liver Clinic who either had histological features in their liver biopsies that were consistent with LALD or who had diagnoses of non-alcoholic steatohepatitis (NASH), NAFLD or cryptogenic cirrhosis, and genetic testing for patients found to have reduced LAL activity to detect LALD carriers.MethodEligible patients were consented for LALD screening. A single sample of blood was obtained either from a finger prick or from a venous blood sample. The blood was transferred to a DBS filter paper for processing. LAL activity <0.03 nmol/punch/h was diagnostic of LALD.Patients with reduced LAL activity were offered genetic testing. Consenting patients gave a venous blood sample of 3ml.Results1730 patients were screened for LALD from 8 centres in the UK. None of the patients in the cohort tested positive for LALD. 27 patients consented to have genetic testing. No abnormalities were detected. 100 patients in the Liver cohort were screened for LALD and none was positive for LALD.ConclusionUsing the eligibility criteria we adopted, the detection rate of LALD was meagre. In our cohorts, we did not identify any patient with undiagnosed LALD in hospital Lipid, Diabetes or Liver clinics.
Prevalence of subclinical mastitis, its associated bacterial isolates and risk factors among cattle in Africa: a systematic review and meta-analysis
Authors: Khasapane Ntelekwane George , Thekisoe Oriel Moeti Molifi , Byaruhanga Charles , Khumalo Zamantungwa , Nkhebenyane Sebolelo Jane 
Published: February 2022

Abstract
Background: Subclinical mastitis (SCM) is one of the most economically important diseases affecting the dairy industry. The SCM does not cause visible changes in the udder or physical changes of the milk as compared to clinical mastitis, and a clear overview of the prevalence and risk factors in the different regions of Africa is still lacking. The objective of this study was to investigate the prevalence of SCM and assess the associated risk factors and dominant bacterial pathogens among cattle in Africa. Materials and methods: Using a systematic review and meta-analysis approach, we gathered literature concerning SCM among cattle in Africa, published from 2020 through 2021in five databases. Results: A total of 1,560 records were retrieved and at the end of the screening, 38 studies were eligible for inclusion in the meta-analysis. The random-effects meta-analysis model showed that the weighted pooled prevalence of SCM in cattle in Africa was 51.5% (95% CI: 44.0-58.9%). Heterogeneity was high and significant as I2 (proportion of observed variation) was 98.4% (95% CI: 97.6-99.0%), τ2 was 0.0533 (95% CI: 0.035-0.089), and the Cochran Q statistic was 2244.97 (p<0.0001). Sub-group and meta-regression analyses showed that West Africa had the highest point estimate (85.3%), followed by East Africa (64.1%), and the least was for southern Africa (16.3%) (p=0.007). Other significant moderators for SCM were age (p<0.0001), breed (p=0.015) and parity (p=0.0001) of cattle. Staphylococcus species were the most predominant pathogens, followed by Streptococcus and Escherichia spp. Conclusions: The present study showed a high variation of subclinical mastitis prevalence in various parts of Africa. There is a need for more data on subclinical mastitis in some regions on the continent. The information gathered in this paper may be used to guide a multidisciplinary approach to the management, control and reduction of this infection.
The long non-coding RNA ‘TRASH’ is essential for cell survival in MAPK-driven melanoma
Authors: Feichtenschlager Valentin , Chen Linan , Zheng Yixuan , Ho Wilson , Sanlorenzo Martina , Vujic Igor , Fewings Eleanor , Lee Albert , Chen Christopher , Lin Kevin , Callanan Ciara , Vujic Marin , Hwang Yeonjoo , Lai Kevin , Chen Stephanie , Nguyen Thuan , Muñoz Denise , Kohwi Yoshinori , Posch Christian , Daud Adil , Rappersberger Klemens , Kohwi-Shigematsu Terumi , Coppé Jean-Philippe , Ortiz-Urda Susana 
Published: February 2022

Abstract
MAPK-pathway up-regulation is responsible for over 40% of human cancer cases. Finding effective therapeutic targets for melanoma therapy continues to be a challenge due to drug resistance. Using a computational and experimental pipeline, we discovered the nuclear enriched long non-coding RNA (lncRNA) TRASH, which is induced upon MAPK-pathway-activation in melanoma. LncRNA hold essential regulatory functions in many cancer types. TRASH-targeting Antisense Oligonucleotides (TRASH-ASOs) greatly reduced cell-growth of melanoma cells in culture and systemic TRASH-ASO treatment significantly inhibited tumor growth of melanoma cell-line and patient-derived tumor xenografts without apparent side effects. We found that TRASH is essential for protein stability of the MAPK-pathway-regulating and apoptosis-inhibiting oncogene hnRNPA2/B1. TRASH knockdown induced apoptosis by down-regulating anti-apoptotic kinase activity and pro-survival signaling pathways. Compared to the well-studied oncogenic lncRNA MALAT1, the unique feature of TRASH is that it governs tumor cell-survival through maintaining activity of anti-apoptotic kinases and pro-survival signaling pathways in melanoma cells. TRASH-ASO treatment can bypass MEK-inhibitor (MEKi) resistance, and unlike MEKi, it does not induce early-onset treatment resistance. Furthermore, TRASH-ASO and MEKi combinations confer synergistic effects in melanoma treatment. Our findings show that TRASH-ASO treatment presents promising features for long lasting RNA-targeting melanoma therapy.
New paleoclimatic evidence of an extraordinary rise in temperature in the Northern Hemisphere in the last 3-4 decades.
Authors: Ogurtsov Maxim 
Published: February 2022

Abstract
Prognosis of temperature changes in the Northern Hemisphere for the period 1980-2020 was made using four temperature paleoreconstructions covering the last 1-2 millennia and ending 1979-1993. A part of paleodata before 1860 (prior to the beginning of a noticeable anthropogenic impact) was used as an information bank. Forecasts were made using nonlinear prediction method which is based on the reconstruction of the trajectory of the predicted series dynamic system in a pseudo-phase space. In all four cases, the forecast gave either a decrease or a very slight increase in temperature during 1980-2020. Statistical experiments performed with using prediction errors have shown that a rise in temperature by 0.15-0.20°C degrees in the indicated epoch is not excluded, but its probability is low (P <0.15). This means that if the climate in the 20th - early 21st century was controlled by the same dynamic system as before 1860, the noticeable warming of the Northern Hemisphere in 1980-2020 should not be observed. While the actual rise of the recorded temperature is sharp and reaches 1.0°C. Such divergence indicates that the climate of the Northern Hemisphere in the last 30-40 years was significantly affected by an additional factor that did not act in the previous 1-2 millennia. The possible influence of the problem of divergence in tree-ring research on the result obtained is discussed.
Gene Network Inference from Single-Cell Omics Data and Domain Knowledge for Constructing COVID-19-Specific ICAM1-Associated Pathways
Authors: Odaka Mitsuhiro , Magnin Morgan , Inoue Katsumi 
Published: February 2022

Abstract
ICAM-1 is critical for interactions between cells. Previous studies have suggested that ICAM-1 triggers cell-to-cell transmission of HIV-1 or HTLV-1. SARS-CoV-2 shares several features with these viruses in interactions between cells, and SARS-CoV-2 cell-to-cell transmission is associated with COVID-19 severity. However, ICAM-1 and its associated pathways are not identified as essential factors in interactions between cells in COVID-19. For example, the current COVID-19 Disease Map has no entry for those pathways. Therefore, discovering unknown ICAM-1 pathways will be indispensable for clarifying the mechanism of COVID-19. This study builds ICAM1-associated pathways by gene network inference from single-cell omics data and multiple knowledge bases. First, data analyses extracted coexpressed genes with significant differences in expression levels with spurious correlations removed. Second, knowledge bases validate models. Finally, mapping the models onto existing pathways identifies new ICAM1-associated pathways. These pathways indicate that (1) upstream pathways include proteins in noncanonical NF-kappaB pathway and that (2) downstream pathways contain integrins and cytoskeleton or motor proteins for cell transformation. In this way, data-driven and knowledge-based approaches are integrated into gene network inference for ICAM1-associated pathway construction. The results can contribute to repairing and completing the COVID-19 Disease Map, thereby improving our understanding of the mechanisms of COVID-19.
A Radiometrically Dated Record of Antarctic Ice Sheet Response to Millennial-Scale Climate Cycles during Glacials and Interglacials
Authors: Piccione Gavin , Blackburn Terrence , Tulaczyk Slawek , Rasbury Troy , Hain Mathis , Ibarra Daniel , Methner Katharina , Tinglof Chloe , Cheney Brandon , Northrup Paul , Licht Kathy 
Published: February 2022

Abstract
Records of changing ice mass in offshore sediments and ice cores suggest that the West Antarctic ice sheet experienced millennial-scale ice loss during the last termination. However, the distal location and short temporal coverage of these records leads to uncertainty in both the spatial footprint of ice response, and whether this response persists outside of glacial terminations. Here we present a >100kyr archive of episodic Antarctic ice sheet basal melt events recorded by mineralogic variation in subglacial precipitates. 234U-230Th dates for two precipitates are used to build a time series of 32 opal-calcite transitions that correspond to Late Pleistocene millennial-scale climate cycles, with precipitation of opal during cold periods and calcite during warm periods. Geochemical data indicate that opal precipitation occurs via cryoconcentration of silica in brines beneath the ice sheet margin, while calcite precipitation is triggered by the addition of subglacial meltwater originating from the ice sheet interior. These freeze-flush cycles represent changes in subglacial hydrologic-connectivity driven by ice sheet velocity fluctuations, which likely occur in response to Southern Ocean thermal forcing acting on grounding lines within the Ross Embayment. Our results suggest that oscillating temperatures in the Southern Ocean affect the mass of the Antarctic ice sheet by regulating the delivery of heat to buttressing ice shelves and grounding lines on millennial timescales, regardless of the background climate state.
Numerical Study on Dynamic Response of RC Slabs Subjected to Cyclic Blast Loading
Authors: Wang Xinyu , Dong Bin , Gao Xicai , Hu Bin , Liang Yaozhe , Wang Junbo 
Published: February 2022

Abstract
Finite element (FE) model which can be used to investigate accumulated damage of the reinforced concrete (RC) slabs under cyclic blast loading is proposed. Firstly, accuracy of the FE model is verified through an experiment. Secondly, effects of the explosive inclination angle, standoff distance, and the explosive mass on the dynamic response of RC slabs are studied. At last, accumulated damage of the reinforced concrete (RC) slabs under cyclic blast loading is presented using the FE model. It is indicated that parameters of the explosive inclination angle, the scale distance, and the explosive mass have strong influences on the dynamic behavior of RC slabs. Under cyclic blast loading with small explosive charge, damage of the RC slab mainly appears in the first blast cycle. Displacement of the RC slab, axial force and strain of the rebars increase remarkably, which could be the mainly reason that damage evolution of the RC slab is not obvious, in the second blast cycle.
Parent training effects on emotion recognition in mothers rearing children with attention-deficit/hyperactivity disorder: A randomized controlled functional magnetic resonance imaging study
Authors: Makita Kai , Yao Akiko , Shimada Koji , Kasaba Ryoko , Fujisawa Takashi X , Mizuno Yoshifumi , Tomoda Akemi 
Published: February 2022

Abstract
This randomized controlled study aimed to examine neurological changes in socioemotional processing skills through parent training in caregivers of children with attention-deficit/hyperactivity disorder. Thirty mothers of children with ADHD were stratified into parental training and non-parental training groups. Functional magnetic resonance imaging was performed during the ‘Reading the Mind in the Eyes’ test, and parenting difficulties were evaluated using the Parenting Stress Index and Parenting Scale twice—before and after parental training. Parenting Stress Index and Parenting Scale scores significantly decreased after parental training. Activity in the left occipital fusiform gyrus increased during the task to estimate emotions from facial pictures, with decreased response time only seen after parental training. Therefore, brain activity changes and enhanced responses after parental training might reflect an increased sensitivity and responsivity to others’ mental state. The present results suggest that parental training promotes mothers’ understanding of problematic behavior in children with attention-deficit/hyperactivity disorder, which could help build a more nurturing environment, reduce parenting stress and a maladaptive parenting style, and improve the mother-child relationship.
Early Urine Infection Prediction Framework using XGBoost Ensemble Model in IoT-Fog Environment
Authors: Gupta Aditya , Singh Amritpal 
Published: February 2022

Abstract
Urine infections are one of the most prevalent concerns for the healthcare industry that may impair the functioning of the kidney and other renal organs. As a result, early diagnosis and treatment of such infections are essential to avert any future complications. Conspicuously, in the current work, an intelligent system for the early prediction of urine infections has been presented. The proposed framework uses IoTbased sensors for data collection, followed by data encoding and Infectious Risk Factor computation using the XGBoost algorithm over the fog computing platform. Finally, the analysis results along with the healthrelated information of users are stored in the cloud repository for future analysis. For performance validation, extensive experiments have been carried out and results are calculated based on real-time patients’ data. The statistical results of accuracy(91.45%), specificity(95.96%), sensitivity(84.79%), precision(95.49%), and f-score(90.12%) reveal the significantly improved performance of the proposed strategy over other baseline techniques.
A Heterogeneous Spatial Correlation Model for WSN Applications
Authors: kumar deo , kumar Sanjeet 
Published: February 2022

Abstract
In densely deployed Wireless Sensor Network, a large number of sensor nodes in an event area observes the event information and sends information to the sink. Due to physical properties related to sensed event, the sensor observations are highly spatially correlated with respect to location of sensor nodes. In this paper we have proposed a heterogeneous correlation model that exploits the spatial correlation between each sensor nodes. Heterogeneous WSNs consists of normal nodes and advance nodes with different sensing range. With the help of sensor coverage model and location of sensor nodes, heterogeneous correlation functions are derived to analyze the correlation characteristics of observed information’s by sensor nodes. The case studies using heterogeneous correlation functions are performed to study the spatial relationship among sensor nodes. Finally, a correlated clustering algorithm is proposed for efficient medium access and clustering protocol for heterogeneous WSNs.
TLR3 Gene Regulates Cataract-Related Mechanisms Through The Jagged-1/Notch Signaling Pathway
Authors: Chen Yu , Yang Rui 
Published: February 2022

Abstract
Objective: Epithelial-mesenchymal transition (EMT) is the main cause of organ fibrosis and a common pathogenesis of most cataracts. Therefore, TLR3 may play a vital role in the progress of PCO EMT. This study aims to explore the molecular mechanism of TLR3 in the occurrence and development of post-cataract EMT, and to provide new ideas for the prevention and treatment of posterior capsule opacification (PCO).Materials and Methods: The expression of TLR3 and EMT-related factors in samples from normal and PCO patients was measured by qPCR. In the presence or absence of TLR3, human lens epithelial cell line SRA01/04 are treated with TGF-β2. The CCK-8 method measures cell proliferation, and the Transwell method detects migration and invasion. The expression of EMT-related molecules and Jagged-1/Notch signaling pathway was analyzed by Western blot and qPC experiments.Result: In terms of mechanism, the functional gain and loss experiments of human LEC show that TLR3 regulates the proliferation, migration, invasion of LEC and EMT induced by TGF-β2 by targeting the Jagged-1/Notch signaling pathway to affect the development of fibrotic cataract.Conclusion: These findings indicate that TLR3 prevents the progression of lens fibrosis by targeting the Jagged-1/Notch signaling pathway to regulate LEC proliferation, migration, invasion and TGF-β2-induced EMT. "TLR3-Jagged-1/Notch" signal axis may be a therapeutic target for the treatment of fibrotic cataract.