bluuebunny/crossref_metadata_2025_split huggingface dataset:
Siap Sekolah dari Rumah: Stimulasi Aspek Sosial-Emosional pada Anak Usia Dini
Authors: Saptandari Edilburga Wulan , Febriani Arum , Kisriyani Ammik 
Published: August 2022

Anak yang memiliki keterampilan sosial-emosional yang baik cenderung bisa beradaptasi dengan lingkungan dan berhasil dalam pembelajaran. Namun, kondisi pandemi COVID-19 telah membuat interaksi sosial anak menjadi sangat terbatas. Studi ini adalah kajian literatur untuk mengetahui pentingnya kematangan sosial-emosional anak usia dini dalam persiapan memasuki Sekolah Dasar dan bagaimana cara stimulasinya. Studi ini diawali dengan menetapkan beberapa kata kunci yang relevan dengan topik penelitian, menerapkan kriteria inklusi pada artikel yang akan dicari, pencarian artikel, dan diakhiri dengan penulisan kajian literatur. Pada kondisi pandemi COVID-19, stimulasi berbasis rumah menjadi hal yang penting untuk dioptimalkan. Keterlibatan orangtua dan significant others, sebagai sistem terdekat anak (mikrosistem), sangat dibutuhkan agar anak bisa mencapai perkembangan sosial-emosional sesuai tahapan usianya. Implikasi dari hasil penelitian ini adalah dapat menjadi masukan bagi orangtua untuk terlibat aktif dalam memberikan stimulasi perkembangan sosial-emosional anak. Harapannya, stimulasi berbasis rumah ini akan dilakukan oleh orangtua secara konsisten, bukan hanya dalam kondisi pandemi COVID-19.
Strategi Guru Pendidikan Anak Usia Dini dalam Menghadapi era Society 5.0
Authors: Ruwaida Gina Asri , Setiasih Ocih 
Published: August 2022

Kemajuan teknologi dan informasi kini memasuki era Society 5.0. Kemajuan era Society 5.0 menunut guru untuk melakukan penyesuaian pembelajaran agar senantiasa sesuai dengan perkembangan zaman. Penelitian ini bertujuan untuk memaparkan strategi pembelajaran yang dilakukan guru pendidikan anak usia dini menghadapi era Society 5.0. Subjek penelitian merupakan guru Pendidikan Anak Usia Dini di Bandung yang berjumlah tiga orang. Metode penelitian yang digunakan pada penelitian ini yakni deskriptif kualitatif menggunakan studi kasus dengan wawancara mendalam. Hasil wawancara kemudian ditranskrip dan dilakukan pengkodean. Hasil penelitian menunjukkan bahwa strategi guru pendidikan anak usia dini dalam menghadapi era society 5.0 yakni menguasai perangkat digital untuk pembelajaran, senantiasa memperbaharui wawasan, melakukan pembelajaran blended/hybrid, menggunakan media pembelajaran yang dapat digunakan secara daring maupun tatap muka, serta saat pembelajaran tatap muka guru perlu mengoptimalkan interaksi anak dan guru secara langsung. Penelitian ini diharapkan mampu memberikan gambaran strategi yang perlu dilakukan guru pendidikan anak usia dini dalam menghadapi era society 5.0
Surgical management of high-grade lumbar spondylolisthesis associated with Hajdu-Cheney syndrome: illustrative case
Authors: Ndongo Sonfack Davaine J. , Bergeron David , Wang Zhi , Boubez Ghassan , Shedid Daniel , Yuh Sung-Joo 
Published: August 2022

BACKGROUND
Hajdu-Cheney syndrome (HCS) is a rare connective tissue disorder characterized by severe bone demineralization. In the spine, it is associated with the early onset of severe osteoporosis and can cause spondylolisthesis. Spinal instrumentation in the setting of severe osteoporosis is challenging because of poor resistance of vertebrae to biomechanical stress.

OBSERVATIONS
A 59-year-old woman with known idiopathic HCS presented with a grade 4 L5-S1 spondylolisthesis and right L5 pedicle fracture associated with a left L5 pars fracture, causing a progressive L5 radiculopathy that was worse on the left side than the right side and bilateral foot drop. The authors performed decompressive lumbar surgery, which included a complete L5 laminectomy and resection of the left L5 pedicle. This was followed by multilevel lumbosacral instrumentation using cement-augmented fenestrated pedicle screws as well as transdiscal sacral screws and bilateral alar-iliac fixation. Postoperatively, the radicular pain resolved, and the left foot drop partially recovered.

LESSONS
Stabilization of high-grade spondylolisthesis in the setting of bone demineralization disorders is challenging. The use of different instrumentation techniques is important because it increases biomechanical stability of the overall instrumentation construct.
Central nervous system mature teratoma producing carbohydrate antigen 19-9: illustrative case
Authors: Takeuchi Shu , Arakawa Yoshiki , Takeuchi Yasuhide , Minamiguchi Sachiko , Tanji Masahiro , Mineharu Yohei , Haga Hironori , Miyamoto Susumu 
Published: August 2022

BACKGROUND
Central nervous system (CNS) mature teratoma is a rare disease with symptoms that can vary according to tumor location. Most lesions are benign; rarely, malignancy can develop in any of the somatic components. Elevated levels of tumor markers such as α-fetoprotein and β-human chorionic gonadotropin are not usually found in patients with CNS mature teratoma, and no reports have described an association with carbohydrate antigen 19-9 (CA19-9).

OBSERVATIONS
A 64-year-old woman with headache was found to have a mass lesion in the anterior cranial fossa. Magnetic resonance imaging of the brain suggested a mature teratoma. Serum and cerebrospinal fluid (CSF) tests showed significant CA19-9 elevations (2,770 U/mL and 4,387 U/mL, respectively). Other examinations, including whole-body 18F-fluorodeoxyglucose positron emission tomography, did not detect the origin of elevated CA19-9, suggesting that the high CA19-9 levels were caused by intracranial tumor. The patient underwent tumor removal. The histopathological diagnosis was mature teratoma with positive CA19-9 staining. CA19-9 levels in serum and CSF decreased significantly after tumor removal.

LESSONS
The histopathological findings and postoperative decreased CA19-9 levels established the diagnosis of CA19-9–producing CNS mature teratoma. CNS mature teratoma can cause elevations in CA19-9 in cases with absence of neoplasms in the trunk.
PERANCANGAN SISTEM INFORMASI BERBASIS ORIENTASI OBJEK MENGGUNAKAN STAR UML DI CV NIASA BANDUNG
Authors: Yusman Nova Indrayana 
Published: August 2022

In terms of data processing information, in NIASA CV there is no permanent systemyet, did not use any application like Microsoft Excel and others. For the size of a company, according to the author's observations there are many weaknesses, and the system used so far is only the result of the calculation of the purchase of raw materials and the sale of finished goods. The report also took a long time to record it because there is no bookkeeping.In this design system using the method of survey in the collection and processing of data information to contain a picture of the situation in place of research object. As for system design, the author uses Unified Modeling Language (UML). UML it self are one of many tools under Object Oriented Programming, so safe to assume that Star UML will be the right tool for analyze. The design is now expected to facilitate users in reporting and the owners of Niasa CV can view or collect reports easily, quickly, and probably help the CV to have a permanent system.
PERENCANAAN ARSITEKTUR SISTEM INFORMASI PT. MA’SOEM ARIAS DENGAN MENGGUNAKAN ORACLE ENTERPRISE ARCHITECTURE FRAMEWORK
Authors: Purnama Soni Ayi 
Published: August 2022

Utilization of information systems and information technology is needed in supporting business processes of a company, because the information system is one of the important things in the key to success of a company. Along with the development of information systems have an information system architecture model, where the information system architecture is necessary to plan the information system architecture to be built in the future, where the information system architecture as a spear to improve the competitiveness of a company with other companies. PT. Ma'soem Arias is one of Pertamina lubricant distributor in West Java. The business activities carried out are to sell Pertamina lubricants to direct customers and direct lubricant procurement from Pertamina's producers. PT. Ma'soem Arias until now in carrying out its business process has not used the information system so needed an Enterprise Architecture planning for PT. Ma'soem Arias.Enterprise architecture model used in this research is by using Oracle Enterprise Architecture Framework (OEAF) model. The advantages of OEAF is to use object oriented concept, where the concept approaches the problem from the perspective of the object and not the perspective of the functional so it is easy to be understood. The method used is Oracle Architecture Development Process (OADP) method, where OADP method has several stages, ie from start of study about business architecture, architecture vision, current state architecture and future state architecture.The result of this research is recommendation of information system of PT. Ma'soem Arias is a blueprint for enterprise architecture planning that succeeds in defining 4 main business processes, the data architecture produces 24 entities, 4 applications and for its technological architecture produces technology architecture proposal.
Does Swallow Droppings and NPK Fertilizer Have a Good Impact on Onion Growth And Results on Peat?
Authors: Putra Adam Bramantara , Cahyono Erik 
Published: August 2022

Shallots are one of the horticultural commodities that are very often used to be a flavoring for dishes. Tanah peat as a medium for growing shallots has many obstacles including low nutrient availability, low pH, organic matter that has not been decomposed so that the nutrient content especially macro nutrient such as low N, P and K. Usaha to fix it is to give swallow manure and NPK compound fertilizer. The purpose ofthis research is toobtain the interaction of doses of swallow manure and NPK fertilizer for the best growth and yield of shallots on peatlands. This research was carried out on March 7, 2020 to May 9 2020 at Jalan Reformasi, Southeast Pontianak District, Kota Pontianak, West Kalimantan. The design used in this study is a Randomized Designof Factorial Group (RAKF) which consists of 2 factors , namely the first factor is the application of swallow feces consisting of 3 levels , and the second facto isthe application of NPK fertilizer, whose plotconsists of 3 levels with a total of 9 treatments including 20 tons / hectare of swallow manure and 400 kg / hectare of NPK fertilizer, 20 tons of swallow manure and 500 kg/hectare of NPK fertilizer, 20 tons/hectare of swallow manure and 600 kg/hectare of NPK fertilizer, 30 tons/hectare of swallowmanur and 400 kg/hectare of NPK fertilizer, 30 tons/hectare of manure swallows and 500 kg/hectare of NPK fertilizer, 30 tons of swallow manure and 600 kg/hectare of NPK fertilizer, 40 tons/hectare of swallow manure and 400 kg/hectare of NPK fertilizer, 40 tons/hectare of swallow manure and 500 kg/hectare NPK fertilizer, 40 tons/hectare of swallow manure and 600 kg/hectare of NPK fertilizer. The treatment was repeated 3 times, and each experimental unit consisted of 15 plant samples. The variables in this study were planting height, number of leaves per clump, number of saplings per clump, root volume, total dry weight per plant, fresh weight of tubers per clump, dry weight wind tubers per clump, yield per plot, The results of theian research showed that the application of 30 tons / hectare of swallow manure and 400 kg / hectare of NPK fertilizer on shallots was the best interaction dose to increase the yield of fresh weight of bulbs and wind dry weight of tubers.
Development of Mathematics Teaching Materials Based on Character Education in The New Normal Era
Authors: Nasrulloh M Farid , Verdianingsih Eliza , Hayati Indah Ismi 
Published: August 2022

The purpose of this research is to design appropriate character education-based teaching materials to help students learn and train math skills. This research uses Research and Development method adapted in ADDIE model development. The subjects of this study were grade VIII of students at MTs Al-Ihsan Kalikejambon school year 2020/2021. The data collection techniques are interviews and questionnaires. Researchers designed a teaching material in the form of teaching materials based on character education. The results of this study showed that (1) Validation of character education-based teaching materials developed by expert assessments obtained a percentage of 80.4% with a fairly valid category. (2) The practicality of character education-based teaching materials by the assessment of math teachers obtains a percentage of 83.63% with a very practical category. (3) The response of students to teaching materials based on character education gets a percentage of 82.94% with a very practical category. Based on the results of the above study, the researchers concluded that character education-based teaching materials are declared valid and practical based on the assessment of experts and learners, so that character education-based teaching materials are eligible for use in mathematics learning.
RETN Gene Single Nucleotide Polymorphism Profile on Triglyceride-Glucose Index as Insulin Resistance Proxy Among Cohort Population of Non-Communicable Diseases in Bogor
Authors: Dany Frans , Nikmah Uly Alfi , Rinendyaputri Ratih , Ernawati Fitrah , Kristanti Dewi , Retiaty Fifi 
Published: August 2022

Genetic factors such as single nucleotide polymorphisms (SNPs) are thought to contribute to the increasing incidence of diabetes mellitus (DM) through insulin resistance. SNPs in the RETN (resistin) gene encoding the resistin protein have been reported to play a role in causing abnormalities in blood glucose and lipid metabolism. Still, studies related to this have rarely been explored in cohort population models. This study aimed to evaluate the relationship of resistin gene SNPs to the trend of the triglyceride-glucose index (TyG) as a proxy for insulin resistance. The data were obtained from the results of the biomedical laboratory examination among participants of a cohort study in the Kebon Kalapa subdistrict, Bogor, every odd year period between 2015-2021 and from RETN genotyping (rs3745367). The generalized linear model (GLM) repeated measurement technique was used with the TyG index value as the dependent variable. The results of the GLM analysis showed that although there was a significant difference in the trend of the TyG index between the observation periods [F(2,87, 1671,1)=41,10, p-value <0.001], that’s not the case for RETN gene SNP [F(5,73, 1671,1) = 1.09, p-value = 0.367]. However, the multivariate test results suggested the association of these SNPs with age and DM status [F(4, 583)=2.48, p-value = 0.043]. In conclusion, RETN gene SNPs may require interaction with other factors or genes to induce insulin resistance or act by indirect glucose–fatty acid metabolic cycle mechanisms.
Multifunctional PEGylated Niosomal Nanoparticle-Loaded Herbal Drugs as a Novel Nano-Radiosensitizer and Stimuli-Sensitive Nanocarrier for Synergistic Cancer Therapy
Authors: Afereydoon Saeid , Haghiralsadat Fateme , Hamzian Nima , Shams Ali , Hemati Mahdie , Naghib Seyed Morteza , Shabani Masoud , Zandieh-doulabi Behrouz , Tofighi Davood 
Published: August 2022

Nowadays, radiotherapy is one of the most effective treatments for breast cancer. In order to overcome the radioresistance of cancer cells, radio-sensitizing agents can be used combined with irradiation to increase the therapeutic efficiency. Curcumin can enhance the radiosensitivity of cancer cells and decrease their viability by the accumulation of these cells in the G2 phase. The encapsulation of curcumin in a nanoniosomal delivery system increases aqueous solubility and bioavailability, resulting in increased radio sensitivity. The present study aimed to enhance the radio-sensitizing effect of the curcumin-containing nanoniosome (Cur-Nio) when combined with irradiation. Thus, curcumin (0.5 mg ml−1) was loaded on a PEGylated nanoniosome containing Tween 60, cholesterol, DOTAP, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) (DSPE-PEG) (at ratios of 70:30:10:5, respectively) by the thin-film hydration method. The particle size, zeta potential, entrapment efficiency, and drug-release rate of formulated nanoniosomes were determined. In order to assess cytotoxicity and apoptosis, different doses of irradiation along with various concentrations of free curcumin and Cur-Nio (single or in combination with irradiation) were treated with breast cancer cells. The particle size and zeta potential of Cur-Nio were reported to be 117.5 nm and −15.1 mV, respectively. The entrapment efficiency (EE%) and loading capacities were 72.3% and 6.68%, respectively. The drug-release rate during 6 h was 65.9%. Cell survival in the presence of curcumin at doses of 1 and 3 Gy showed a significant reduction compared with cells irradiated at 48 h and 72 h (p &lt; 0.000). Also, the rate of cytotoxicity and apoptosis was significantly higher in cells treated with the combination of curcumin-containing nanoniosomes and irradiation in comparison with those treated with free curcumin. These findings indicate that the efficacy of pre-treatment with Cur-Nio as a radiosensitizer during radiotherapy enhances irradiation-induced breast cancer cell apoptosis and is a useful strategy to increase the effectiveness of breast cancer therapy.
Construction of a combined hypoxia and EMT index for head and neck squamous cell carcinoma
Authors: Li Huan , Wang Jun , He Lei , Zhang Fengrui , Meng Qingzhe , Huang Junhong , Li Yahui , Liu Rong , Yang Xinjie , Wei Jianhua 
Published: August 2022

Objectives: In head and neck squamous cell carcinoma (HNSCC), the interaction between epithelial-mesenchymal transformation (EMT) and hypoxia has been confirmed, and corresponding treatment methods have been investigated. Few studies have examined its combined effects and its potential clinical use, however. As a result, we developed a new scoring system based on EMT and hypoxia.Methods: We combined 200 hypoxia-related genes with 1184 EMT-related genes and finally constructed a score risk model containing 14 characteristic factors named the comprehensive index of EMT and hypoxia (CIEH) by the Lasso-Cox regression and univariate Cox regression method, which is used to predict prognosis and to guide treatment planning in HNSCC patients. Furthermore, we examined HNSCC expression of CIEH-related genes using the human protein atlas database.Results: Based on survival analysis results, CIEH value had a high prognostic value in HNSCC patients, a high CIEH value carries a poor prognostic significance in HNSCC. It is noteworthy that the CIEH value was correlated with tumor immune infiltration. Moreover, the CIEH had significant differences in age, stage, N, laterality, and peripheral nerve invasion, and that the CIEH could be an independent prognostic factor.Conclusions: This study constructed a CIEH model containing 14 characteristic factors, including hypoxia-related genes and EMT genes, that may be able to serve as potential biomarkers for HNSCC. According to the 14 characteristic factors in the CIEH model, a diagnostic kit can be packaged in the future to evaluate the survival of patients before tumor surgery and guide the subsequent treatment plan.
Live functional assays reveal longitudinal maturation of transepithelial transport in kidney organoids
Authors: Rizki-Safitri Astia , Gupta Navin , Hiratsuka Ken , Kobayashi Kenichi , Zhang Chengcheng , Ida Kazumi , Satlin Lisa M. , Morizane Ryuji 
Published: August 2022

Kidney organoids derived from hPSCs have opened new opportunities to develop kidney models for preclinical studies and immunocompatible kidney tissues for regeneration. Organoids resemble native nephrons that consist of filtration units and tubules, yet little is known about the functional capacity of these organoid structures. Transcriptomic analyses provide insight into maturation and transporter activities that represent kidney functions. However, functional assays in organoids are necessary to demonstrate the activity of these transport proteins in live tissues. The three-dimensional (3D) architecture adds complexity to real-time assays in kidney organoids. Here, we develop a functional assay using live imaging to assess transepithelial transport of rhodamine 123 (Rh123), a fluorescent substrate of P-glycoprotein (P-gp), in organoids affixed to coverslip culture plates for accurate real-time observation. The identity of organoid structures was probed using Lotus Tetragonolobus Lectin (LTL), which binds to glycoproteins present on the surface of proximal tubules. Within 20 min of the addition of Rh123 to culture media, Rh123 accumulated in the tubular lumen of organoids. Basolateral-to-apical accumulation of the dye/marker was reduced by pharmacologic inhibition of MDR1 or OCT2, and OCT2 inhibition reduced the Rh123 uptake. The magnitude of Rh123 transport was maturation-dependent, consistent with MDR1 expression levels assessed by RNA-seq and immunohistochemistry. Specifically, organoids on day 21 exhibit less accumulation of Rh123 in the lumen unlike later-stage organoids from day 30 of differentiation. Our work establishes a live functional assessment in 3D kidney organoids, enabling the functional phenotyping of organoids in health and disease.
Assessing Concurrent Adherence to Combined Essential Medication and Clinical Outcomes in Patients With Acute Coronary Syndrome. A Population-Based, Real-World Study Using Group-Based Trajectory Models
Authors: Rodríguez-Bernal Clara L. , Sánchez-Saez Francisco , Bejarano-Quisoboni Daniel , Hurtado Isabel , García-Sempere Anibal , Peiró Salvador , Sanfélix-Gimeno Gabriel 
Published: August 2022

Graphical AbstractOur paper at a glance: assessing concurrent adherence to combined essential medication and clinical outcomes in acute coronary syndrome patients. A population-based, real-world study using group-based trajectory models.
High-resolution magnetostratigraphic records of the pliocene sedimentary successions in Yengisar section, NW China, and its tectonic implications
Authors: Zhou Zaizheng , Pei Junling , Li Jianfeng , Cai Yuhang , Hou Lifu 
Published: August 2022

The Neogene strata upward-coarsening sandstone and conglomerate sequences at the periphery of the Northeastern Pamir record the intense uplift of the paleosurface of the building mountains. To further improve our knowledge of source-sink processes, a detailed magnetostratigraphic investigation was carried out along the Yengisar section, which is located at the southwestern margin of the Tarim Basin. The new high-resolution magnetostratigraphic data revealed that the Artux Formation was deposited from 4.9 Ma to 1.9 Ma with three sedimentation rates changes. The variations in sedimentation rate may be due to the pulsating exhumation of the Western Kunlun Mountain, caused by the northward motion of the Pamir salient. By integrating the evidences from the seismic reflection profile and other magnetostratigraphic investigations in this region, the basal age of the Xiyu Formation and the early stages of growth strata deposition were estimated at ∼1.9 and 1.45 Ma, respectively. Based on the data, we propose that the progradation of the Xiyu Formation and the migration of the deformation front are the two independent responses of the sink region to the uplift events of the source region.