bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the Conceptualization and Operationalization of Trauma‐Informed Care Within and Across Systems: A Critical Interpretive Synthesis
Authors: BARGEMAN MARIA , ABELSON JULIA , MULVALE GILLIAN , NIEC ANNE , THEUER ANIA , MOLL SANDRA 
Published: September 2022

Policy Points
In order to achieve successful operationalization of trauma‐informed care (TIC), TIC policies must include conceptual clarity regarding the definition of both trauma and TIC. Furthermore, TIC requires clear and cohesive policies that address operational factors such as clearly delineated roles of service providers, protocol for positive trauma screens, necessary financial infrastructure, and mechanisms of intersectoral collaboration.
Additionally, policy procedures need to be considered for how TIC is provided at the program and service level as well as what TIC means at the organizational, system, and intersectoral level.
ContextIncreased recognition of the epidemiology of trauma and its impact on individuals within and across human service delivery systems has contributed to the development of trauma‐informed care (TIC). How TIC can be conceptualized and implemented, however, remains unclear. This study seeks to review and analyze the TIC literature from within and across systems of care and to generate a conceptual framework regarding TIC.MethodsOur study followed a critical interpretive synthesis methodology. We searched multiple databases (Campbell Collaboration, Econlit, Health Systems Evidence, Embase, ERIC, HealthSTAR, IPSA, JSTOR, Medline, PsychINFO, Social Sciences Abstracts, Sociological Abstracts and Web of Science),as well as relevant gray literature and information‐rich websites. We used a coding tool, adapted to the TIC literature, for data extraction.FindingsElectronic database searches yielded 2,439 results and after inclusion/exclusion criteria were applied, a purposive sample of 98 information‐rich articles was generated. Conceptual clarity and definitional understanding of TIC is lacking in the literature, which has led to poor operationalization of TIC. Additionally, infrastructural and ideological barriers, such as insufficient funding and service provider “buy‐in,” have hindered TIC implementation. The resulting conceptual framework defines trauma and depicts critical elements of vertical TIC, including the bidirectional relationship between the trauma‐affected individual and the system, and horizontal TIC, which requires intersectoral collaboration, an established referral network, and standardized TIC language.ConclusionsSuccessful operationalization of TIC requires policies that address current gaps in systems arrangements, such as the lack of funding structures for TIC, and political factors, such as the role of policy legacies. The emergent conceptual framework acknowledges critical factors affecting operationalization.
Maternal plasma diacylglycerols and triacylglycerols in the prediction of gestational diabetes mellitus
Authors: Hou Guixue , Gao Ya , Poon Liona C. , Ren Yan , Zeng Chunwei , Wen Bo , Syngelaki Argyro , Lin Liang , Zi Jin , Su Fengxia , Xie Weiwei , Chen Fang , Nicolaides Kypros H. 
Published: September 2022

AbstractObjectiveTo define the lipidomic profile in plasma across pregnancy, and identify lipid biomarkers for gestational diabetes mellitus (GDM) prediction in early pregnancy.DesignCase–control study.SettingTertiary referral maternity unit.Population or SamplePlasma samples from 100 GDM and 100 normal glucose tolerance (NGT) women, divided into a training set (GDM first trimester = 50, GDM second trimester = 40, NGT first trimester = 50, NGT second trimester = 50) and a validation set (GDM first trimester = 45, GDM second trimester = 34, NGT first trimester = 44, NGT second trimester = 40).MethodsPlasma samples were collected in the first (11+0 to 13+6 weeks), second (19+0 to 24+6 weeks), and third trimesters (30+0 to 34+6 weeks), and tested by ultra‐high‐performance liquid chromatography coupled with electrospray ionisation‐quadrupole‐time of flight‐mass spectrometry; The GDM prediction model was established by the machine‐learning method of random forest.Main outcome measuresGestational diabetes mellitus.ResultsIn both the GDM and NGT group, lyso‐glycerophospholipids were down‐regulated, whereas ceramides, sphingomyelins, cholesteryl ester, diacylglycerols (DGs) and triacylglycerols (TGs) and glucosylceramide were up‐regulated across the three trimesters of pregnancy. In the training dataset, seven TGs and five DGs demonstrated good performance in the prediction of GDM in the first and second trimesters (area under the curve [AUC] = 0.96 with 95% confidence interval [CI] of 0.93–1 and AUC = 0.97 with 95% CI of 0.95–1, respectively), independent of maternal body mass index (BMI) and ethnicity. In the validation dataset, the predictive model achieved an AUC of 0.88 and 0.94 at the first and second trimesters, respectively.ConclusionsOur results have proposed new lipid biomarkers for the first trimester prediction of GDM, independent of ethnicity and BMI.
What does democratic management do in Chinese workplaces? Evidence from matched employer–employee data
Authors: Chen Liwen , Su Zhong‐Xing , Wang Guanghua 
Published: September 2022

AbstractDemocratic management (DM) is an important set of statutory employee participation institutions that goes beyond trade unions in Chinese workplaces; however, its effects on pay and performance are unstudied. Using data from the China Employer–Employee Matched Survey, this study examines how DM is associated with pay and performance levels in China. The study finds that DM is positively associated with workers' hourly wages, fringe benefits, and firms' labour productivity on average, suggesting that it is not merely ‘window‐dressing’ as perceived by conventional wisdom. This study also reveals that workplace transparency mediates the relationship between DM and employees' earnings, while the industrial relations climate mediates the relationship between DM and firms' productivity.
Corporate social responsibility: A review of empirical research using Thomson Reuters Asset4 data
Authors: de Villiers Charl , Jia Jing , Li Zhongtian 
Published: September 2022

AbstractThomson Reuters Asset4 (Asset4) is a leading corporate social responsibility (CSR) database often used by practitioners and researchers. This review offers a precise understanding of prior studies using Asset4 and their justification for selecting Asset4, and identifies research opportunities. We review 285 studies using Asset4 data published in quality academic journals, analysing: (1) the usage of Asset4 pillars, categories, data points, and indicators; (2) the justification for using Asset4; and (3) research themes. Our findings provide valuable information for practitioners and researchers who (plan to) use CSR databases, including our guidance on promising avenues for future studies.
Use of tobacco purge in a therapeutic community for the treatment of substance use disorders
Authors: Rumlerová Tereza , Kube Eric , Simonet Nahuel , Friso Fabio , Politi Matteo 
Published: September 2022

AbstractIn the Peruvian Amazon, tobacco (Nicotiana rustica) is considered a master plant and is the main curing tool of local healers. Among its several medicinal uses, we find drinking tobacco juice with the purpose of purging in order to heal on a physical, mental, and spiritual level. This specific practice is part of the addiction treatment protocol developed at Takiwasi Center. The goal of this investigation was to focus on the effects of the tobacco purge as reported by therapists at Takiwasi and to elaborate its relevance within the context of addiction treatment. In order to obtain information on this topic, we performed research fieldwork based on a participant‐observation approach, and retrospective data analysis on information from interviews conducted by psychotherapists with patients. As alleged effects of the tobacco purge, therapists reported that patients experienced feelings of mental clarity with the greatest frequency (n = 80), followed by noteworthy physical effects including discomfort and intoxication (n = 63). An effect on sleep and dreams was also common (n = 36) and many found the experience directly related to addiction treatment and the desire to consume substances (n = 20).
Experiences of Listening to Icaros during Ayahuasca Ceremonies at Centro Takiwasi:An Interpretive Phenomenological Analysis
Authors: Graham Owain J. , Saucedo Gary Rojas , Politi Matteo 
Published: September 2022

AbstractResearch on psychedelic‐assisted psychotherapy has shown that music affects therapeutic outcomes at a fundamental level. The development of such therapies calls for research on the use of music with consciousness‐altering substances, especially in contexts informed by their traditional use. Informed by ethnographic reports, our project answers this call, investigating the phenomenology of listening toicaros(medicine songs) during ayahuasca ceremonies as reported by addiction rehabilitation patients at Perú’s Centro Takiwasi. We found that icaros were therapeutically significant. They elicited experiences of healing by modulating patients’ emotions and the altered state induced by ayahuasca. They helped patients feel safe while guiding them through difficult memories and emotions, and facilitating experiences of healing and learning about their addictions. Thus, similar therapies must carefully consider how they incorporate music in their protocols. We suggest further research to better understand the synergistic, therapeutic effects of music and altered states of consciousness, especially in cross‐cultural environments.
Organizational leadership: How much does it matter?
Authors: Haile Getinet Astatike 
Published: September 2022

AbstractI study the influence of leadership on organizational performance and worker wellbeing using data from the 2004 and 2011 Workplace Employment Relations Survey (WERS). Our most conservative estimates from fixed effects regressions on a panel of organizations reveal that virtuous leadership is significantly and positively linked to an upbeat assessment of organizational performance, and an increase in worker wellbeing. Specifically, the estimates reveal that an increase in leadership quality by one standard deviation increases organizational performance and worker job satisfaction by 0.27 and 0.73 standard deviations, respectively, while it leads to a fall in worker job anxiety by 0.13 standard deviations. The results support the hypothesis that good leadership is vital for the success of business, including worker wellbeing, which organizational policymakers ought to heed. There is a dearth of empirical evidence on organizational leadership as an institution and its influence on organizational outcomes, which this article aims to address.
Outcomes of alpha‐blockers as medical expulsive therapy following shockwave lithotripsy: a systematic review and meta‐analysis
Authors: Brain Eleanor , Geraghty Robert M. , Tzelves Lazaros , Mourmouris Panagiotis , Chatzikrachtis Nikolaos , Karavitakis Markos , Skolarikos Andreas , Somani Bhaskar K. 
Published: September 2022

ObjectivesTo determine stone‐free rate following shockwave lithotripsy (SWL) with/without alpha‐blockers as well as complication rates (individual and classified using the Clavien–Dindo system).Materials and MethodsWe performed a systematic review of all randomized controlled trials that included more than 20 patients (age > 18 years) and examined the use of alpha‐blockers after SWL. Meta‐analysis was performed using ‘metafor’ in R. We report risk ratios (RRs) with 95% confidence intervals (95% CIs). The PROSPERO ID for the trial was: CRD42021248108.ResultsWe assessed 158 full‐text articles and included a total of 21 studies in our review. There were 1445 patients receiving alpha‐blockers and 1478 control patients. Those receiving alpha‐blockers were significantly more likely to be stone‐free (RR 1.12, 95% CI 1.07–1.16; P < 0.001). This effect was robust to ‘trim‐and‐fill’ adjustment. In those taking alpha‐blockers there was a significant reduction in Clavien III–V complications and, on trim‐and‐fill adjustment, a significant reduction in Clavien I–II complications. There were also significant reduction in rates of steinstrasse, pain and requirement for auxiliary procedures. There was no significant difference in retreatment rates. These effects were robust to trim‐and‐fill adjustment.ConclusionsThere is a modest increase in stone‐free rates in those receiving alpha‐blockers following SWL, with a reciprocal modest risk reduction for steinstrasse, pain and auxiliary procedures. However, alpha‐blockers do not reduce the risk of requiring retreatment.
Innate immune activation without immune cell infiltration in brains of murine models of Aicardi‐Goutières Syndrome
Authors: Wiley Clayton A. , Steinman Richard A. , Wang Qingde 
Published: September 2022

AbstractChronic inflammation is frequently invoked as a mechanism of neurodegeneration and yet inflammatory cell infiltrates are seldom seen in brains of these disorders. Different disciplines utilize different technologies and methodologies to describe what is immunologically defined as the innate immune response (IIR). We examined murine models of the human neurodegenerative disease Aicardi‐Goutières Syndrome, where an IIR is initiated by aberrant RNA metabolism secondary to a mutation in adenosine deaminase acting on RNA gene (ADAR1). We previously showed that these mice demonstrated a deficit in RNA editing that lead to MDA‐5 mediated RNA sensing pathway activation of the IIR with massive interferon stimulated gene transcription and translation. As early as 2 weeks of age, in situ hybridization demonstrated that different central nervous system (CNS) cell lineages expressed very high levels of distinct interferon stimulated genes (ISGs) in the absence of interferon and absence of immune cell infiltrates. We have expanded these studies to more completely describe the breadth of ISG expression systemically and in CNS using double label in situ hybridization. Within the CNS aberrant ISG expression was mostly limited to neurons, microglia, ependyma, choroid plexus, and endothelial cells with little expression in oligodendroglia and astrocytes except for STAT1. Wild type controls showed a similar pattern of ISG expression but only in aged mice and at levels minimally detectable by in situ hybridization. Despite months of elevated ISG expression in mutant mice, there was essentially no inflammatory infiltrate, no interferon production and minimal glial reaction. Histomorphological neurodegenerative pathology of ventricular dilatation and deep gray matter mineralization were evident in mutant mice 8–13 months of age but this did not show a spatial relationship to ISG expression. This IIR without immune cell infiltration leads to neurodegeneration through non‐canonical pathways that may accentuate normal aging pathways.
COVID‐19 stressors and symptoms of anxiety and depression in a community sample of children and adolescents
Authors: Watson Kelly H. , Coiro Mary Jo , Ciriegio Abagail E. , Dakkak Angelique , Jones Maile T. , Reisman Jennie , Kujawa Autumn , Compas Bruce E. 
Published: September 2022

BackgroundThe COVID‐19 public health crisis has created abrupt and unparalleled disruptions to the daily lives of children and adolescents across the world, placing them at significant risk for developing symptoms of anxiety and depression.MethodThe current study used two data collection periods to determine which types of COVID‐19‐related stressors were associated with the greatest risk of anxiety and depression symptoms in a community sample of children and adolescents in the United States (U.S.) from May–August 2020 (T1) to February–April 2021 (T2). Seventy‐nine youth (ages 10–17; M = 13.41, SD = 2.10; 54.4% female) completed a battery of online standardized questionnaires about COVID‐19 stress and psychiatric symptoms at T1 and 56 of these also participated at T2.ResultsThe majority of children and adolescents reported experiencing the COVID‐19‐related stressors in multiple domains including daily routines, interpersonal relationships, education, finances, and health. A substantial proportion of the sample reported clinical levels of depression and anxiety symptoms at both T1 and T2. Multiple linear regression analyses revealed that, controlling for T1 anxiety and depression symptoms, T2 interpersonal stressors were significantly associated with elevated depression and anxiety scores at T2.ConclusionsThe findings highlight the salience of social connection for children and adolescents, and may also underscore the risk associated with lockdown restrictions, social distancing, and school closures during the pandemic.
Frequency and impact of musculoskeletal symptoms on quality of life in MEN2B
Authors: Henderson James W. , Montebello Annalisa , Grey Joanna , Druce Maralyn 
Published: September 2022

AbstractObjectiveTo investigate the impact of musculoskeletal (MSK)‐related symptoms on the quality of life of patients with multiple endocrine neoplasia Type 2b (MEN2B).DesignAn online survey was distributed by the Association for Multiple Endocrine Neoplasia Disorders (AMEND) to their members and worldwide via a social media group for MEN2B patients.MethodsThe survey consisted of a detailed questionnaire analysing the MSK‐related symptoms and structural deformities of MEN2B patients and their impact on patient's lives.ParticipantsForty‐eight participants completed the survey.ResultsParticipants reported several musculoskeletal complaints; the most prevalent being musculoskeletal weakness at 73% (n = 35) and pain 58% (n = 28). The median pain score was 7 (interquartile range [IQR]: 5–8) and the frequency of pain was daily in 44% (n = 15) and constant in 21% (n = 7). Structural complaints were common with 63% (n = 30) stating their physique was ‘different' and 40% (n = 19) describing marfanoid body features. Spinal curvature and foot deformities were the commonest structural abnormalities with scoliosis 70% (n = 16) and pes cavus 63% (n = 22) prevailing. Dental problems were mentioned by 69% (n = 33) with interdental spacing being the most common complaint at 61% (n = 20). The musculoskeletal symptoms of MEN2B had a median impact of 6 (IQR: 3–9) on quality of life (QOL) with structural deformities 53% (n = 18) and pain 26% (n = 9) listed as having the highest impact. Poor MSK health affected exercise, work and mobility.ConclusionsWe report a high prevalence of musculoskeletal‐related complaints in MEN2B which significantly affects QOL. This suggests a need to provide better holistic care including a multidisciplinary team with physiotherapist, orthopaedic and dental specialist input.
Loss‐of‐function mutations in SGCE found in Japanese patients with myoclonus‐dystonia
Authors: Azuma Kenko , Horisawa Shiro , Mashimo Hideaki , Fukuda Mitsumasa , Kumada Satoko , Kawamata Takakazu , Taira Takaomi , Akagawa Hiroyuki 
Published: September 2022

AbstractSGCE myoclonus‐dystonia is a monogenic form of dystonia with an autosomal dominant mode of inheritance that co‐occurs with a myoclonic jerk. In this study, we present 12 Japanese patients from nine families with this disease. Targeted next‐generation sequencing covering major causative genes for monogenic dystonias identified nine distinct SGCE mutations from each of the families: three nonsense, two frameshift, two missense, one in‐frame 15 bp deletion, and one splice donor site mutations, of which four were previously unreported. One missense mutation (c.662G>T, p.Gly221Val) was located at the 3′ end of exon 5 (NM_001099400), which was predicted to cause aberrant splicing according to in silico predictions. Minigene assays performed together with the c.825+1G>C mutation demonstrated complete skipping of exon 5 and 6, respectively, in their transcripts. The other missense (c.1345A>G, p.Met449Val) and 15 bp deletion (c.168_182del, p.Phe58_Leu62del) mutations showed a significant reduction in cell membrane expression via HiBiT bioluminescence assay. Therefore, we concluded that all the detected mutations were disease‐causing. Unlike the other detected mutations, p.Met449Val affects only isoform 3 (NP_001092870 encoded by NM_001099400) among the variously known isoforms of SGCE. This isoform is brain‐specific and is mostly expressed in the cerebellum, which supports recent studies showing that cerebellar dysfunction is a key element in the pathophysiology of SGCE myoclonus‐dystonia.
Diagnostik und Therapie von Mycobacterium‐marinum‐Infektionen: Ergebnisse einer retrospektiven monozentrischen Studie
Authors: Strobel Katharina , Sickenberger Christina , Schoen Christoph , Kneitz Hermann , Kolb‐Mäurer Annette , Goebeler Matthias 
Published: September 2022

ZusammenfassungHintergrund und Ziele: In Europa sind Infektionen mit Mycobacterium (M.) marinum selten. Wir führten eine retrospektive Studie durch, um klinisches Spektrum sowie Diagnostik, Therapie und Ergebnisse von M.‐marinum‐Infektionen unter praxisnahen Bedingungen zu analysieren.Patienten und Methodik: In der Datenbank des Universitätsklinikums Würzburg wurden zwischen 1998 und 2018 18 Patienten mit M.‐marinum‐Infektionen identifiziert.Ergebnisse: Zwölf Betroffene berichteten über eine Exposition gegenüber Zierfischaquarien oder Teichen. Sechzehn Patienten präsentierten Hautläsionen an den oberen Extremitäten. Es wurden keine invasiven Infektionen beobachtet. Der durchschnittliche Zeitraum bis zur Diagnosestellung betrug 15 Wochen. Bei 14 Patienten ergab die Histologie eine granulomatöse Entzündung. In 16 Fällen gelang der kulturelle Nachweis. Die meisten Patienten erhielten eine Antibiotika‐Monotherapie (14/18), in vier Fällen wurde eine Kombinationstherapie verabreicht. Die Behandlung (mediane Dauer von 10 Wochen) war bei 13 Patienten erfolgreich. Fünf Patienten stellten sich im Therapieverlauf nicht wieder vor.Schlussfolgerungen: Unsere retrospektive Analyse von M.‐marinum‐Infektionen an einem tertiären Referenzzentrum in Deutschland zeigte eine erhebliche zeitliche Verzögerung in der Diagnosestellung und belegt die Bedeutung von mikrobiologischer Kultur, PCR und Histologie. Eine Monotherapie mit Clarithromycin (anstelle von Doxycyclin) erwies sich als geeignet, während die Behandlung bei immunsupprimierten oder ‐geschwächten Patienten und bei ausgedehnten Befunden durch eine Kombinationstherapie ergänzt wurde.