bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parameters of Ethnic Minorhood
Authors: Hai Peng 
Published: October 2022

Abstract
The current crisis in China’s ethnic frontiers is animating intense discussion as to whether the present moment is a déjà vu of antecedents or an aberration of the Chinese ethno-political normative. Whereas the bulk of new scholarship focuses on the post-Mao era, few studies exist to elucidate the visuality of ethnic relations in the early PRC when state-building was still unfolding in the ethnic frontiers. This paper investigates how an ethnic hierarchy based on a majority-minority binarism was visually constructed during the formative decade of the socialist era (1949–59). Examining several films featuring Inner Mongolia and the socio-political interaction between Mongol indigenes and Han expeditionary personnel, this paper contends that constructing the visuality of Han superiority as adult guardian overlooking ethnic minors who must answer the interpellation of attaining the likeness of the Han was the centrepiece in substantiating a majority-minority binarism beyond a static ethno- demographic condition.
Statistical Downscaling to Improve the Subseasonal Predictions of Energy-Relevant Surface Variables
Authors: Goutham Naveen , Plougonven Riwal , Omrani Hiba , Tantet Alexis , Parey Sylvie , Tankov Peter , Hitchcock Peter , Drobinski Philippe 
Published: October 2022

Abstract
Owing to the increasing share of variable renewable energies in the electricity mix, the European energy sector is becoming more weather sensitive. In this regard, skillful subseasonal predictions of essential climate variables can provide considerable socioeconomic benefits to the energy sector. The aim of this study is therefore to improve the European subseasonal predictions of 100-m wind speed and 2-m temperature, which we achieve through statistical downscaling. We employ redundancy analysis (RDA) to estimate spatial patterns of variability from large-scale fields that allow for the best prediction of surface fields. We compare explanatory powers between the patterns obtained using RDA against those derived using principal component analysis (PCA), when used as predictors in multilinear regression models to predict surface fields, and show that the explanatory power of the former is superior to that of the latter. Subsequently, we employ the estimated relationship between RDA patterns and surface fields to produce statistical probabilistic predictions of gridded surface fields using dynamical ensemble predictions of RDA patterns. We finally demonstrate how a simple combination of dynamical and statistical predictions of surface fields significantly improves the accuracy of subseasonal predictions of both variables over a large part of Europe. We attribute the improved accuracy of these combined predictions to improvements in reliability and resolution.
PrimedSherlock: a tool for rapid design of highly specific CRISPR-Cas12 crRNAs
Authors: Mann James G. , Pitts R. Jason 
Published: October 2022

Abstract
Background
CRISPR-Cas based diagnostic assays provide a portable solution which bridges the benefits of qRT-PCR and serological assays in terms of portability, specificity and ease of use. CRISPR-Cas assays are rapidly fieldable, specific and have been rigorously validated against a number of targets, including HIV and vector-borne pathogens. Recently, CRISPR-Cas12 and CRISPR-Cas13 diagnostic assays have been granted FDA approval for the detection of SARS-CoV-2. A critical step in utilizing this technology requires the design of highly-specific and efficient CRISPR RNAs (crRNAs) and isothermal primers. This process involves intensive manual curation and stringent parameters for design in order to minimize off-target detection while also preserving detection across divergent strains. As such, a single, streamlined bioinformatics platform for rapidly designing crRNAs for use with the CRISPR-Cas12 platform is needed. Here we offer PrimedSherlock, an automated, computer guided process for selecting highly-specific crRNAs and primers for targets of interest.

Results
Utilizing PrimedSherlock and publicly available databases, crRNAs were designed against a selection of Flavivirus genomes, including West Nile, Zika and all four serotypes of Dengue. Using outputs from PrimedSherlock in concert with both wildtype A.s Cas12a and Alt-R Cas12a Ultra nucleases, we demonstrated sensitive detection of nucleic acids of each respective arbovirus in in-vitro fluorescence assays. Moreover, primer and crRNA combinations facilitated the detection of their intended targets with minimal off-target background noise.

Conclusions
PrimedSherlock is a novel crRNA design tool, specific for CRISPR-Cas12 diagnostic platforms. It allows for the rapid identification of highly conserved crRNA targets from user-provided primer pairs or PrimedRPA output files. Initial testing of crRNAs against arboviruses of medical importance demonstrated a robust ability to distinguish multiple strains by exploiting polymorphisms within otherwise highly conserved genomic regions. As a freely-accessible software package, PrimedSherlock could significantly increase the efficiency of CRISPR-Cas12 diagnostics. Conceptually, the portability of detection kits could also be enhanced when coupled with isothermal amplification technologies.
Normalization of technology for social contact in a Norwegian care facility during COVID-19
Authors: Badawy Abeer , Solberg Mads , Obstfelder Aud Uhlen , Alnes Rigmor Einang 
Published: October 2022

Abstract
Background
The COVID-19 pandemic has seen unprecedented growth in the use of interactive technologies in care facilities for social contact between residents and their close contacts due to the need for social distancing. As the pandemic is transitioning into a new phase, there is a need to critically examine the new practices associated with technology usage.

Objective
Our analysis is based on a case study of how a care facility in western Norway adopted a novel technology called KOMP. We empirically investigate the stability of practices with KOMP for maintaining social communication between residents and their relatives and consider whether these practices are likely to last beyond the pandemic. We draw on normalization process theory (NPT) to interpret our findings and critically examine how stable embedding of new technologies for social communication occurs under extraordinary circumstances.

Methods
We conducted a case study based on participant observation and interviews, and the data were analyzed through inductive thematic analysis. Participants are health care professionals from a public care facility in western Norway.

Results
Four major themes emerged from the data. The first revolved around the pressing need for communications between residents and relatives with a suitable tool. Second, staff showed engagement through motivation to learn and adapt the technology in their practices. A third theme centered on how staff and the organization could work effectively to embed KOMP in daily practice. Our fourth theme suggested that the professionals continuously assessed their own use of the technology.

Conclusion
From the perspective of NPT, practices with KOMP have been partially embedded by developing a shared understanding, engaging through cognitive participation, working collectively with staff and the organization, and reflexively monitoring the benefits of using KOMP. However, staff engagement with the technology was continuously threatened by factors related to diverging staff preferences, the burden of facilitating KOMP for residents with impaired cognitive and physical abilities, issues of privacy and ethics, and the technical skills of the residents’ relatives. Our analysis suggests that caring practices via KOMP have become relatively stable despite barriers to engagement and are therefore likely to persist beyond the pandemic.
Ooencyrtus pityocampae Mercet (Hymenoptera: Encyrtidae): a potential biocontrol agent of the seed bug, Leptoglossus occidentalis Heidemann (Heteroptera: Coreidae)
Authors: Tunca Cosic Hilal , Tabone Elisabeth , Çaycı Damla , Cosic Benjamin , Toprak Özgür , Emin Akın 
Published: October 2022

Abstract
Background
Western conifer seed bug, Leptoglossus occidentalis Heidemann (Hemiptera: Coreidae), is an invasive polyphagous pest of coniferous trees. It causes serious economic losses in pine kernel production. Biocontrol of L. occidentalis through the egg parasitoid Ooencyrtus pityocampae Mercet (Hymenoptera: Encyrtidae) seems to be sustainable solution to reduce economic losses of the pest. In this study, the biology of O. pityocampae was investigated on its natural host, L. occidentalis, under laboratory conditions.

Results
In this context, the effects of host age, female age, and temperature on parasitism rate, emergence rate, developmental time, and longevity were investigated. Female age had a great influence on the parasitism rate. Parasitism rates were 8.0, 17.0, and 37.3% in 1-, 3-, and 5-day-old females, respectively. There was no effect of host age or female age on emergence rates at the two different temperatures (25 and 30 °C). Emergence rate ranged from 74.0 to 88.3%. The longest developmental time (17.9 d) was obtained on 3-day-old hosts at 25 °C. The longevity, which was one of the important criteria of the parasitoid, was significantly affected by temperature.

Conclusion
The results of this study on the biology of O. pityocampae may contribute significantly to the biological control studies of L. occidentalis. This egg parasitoid can be mass-produced on lepidopteran hosts for field releases against L. occidentalis.
A case series of premenstrual disorders presenting to the UK's National Female Hormone Clinic
Authors: Reilly Thomas J. , Knox Clare-Louise , Marsh Michael S. , Craig Michael C. 
Published: October 2022

Aims and methodWe aimed to describe the clinical characteristics of female patients presenting with premenstrual disorders to a tertiary service in the UK. We conducted a retrospective case-note review of referrals to the National Female Hormone Clinic from April 2014 to August 2020. Based on clinical assessment, we determined whether the patient met criteria for premenstrual dysphoric disorder or premenstrual exacerbation of an underlying psychiatric disorder.ResultsOf 146 patients seen in clinic for premenstrual disorders, an ICD-10 psychiatric diagnosis was made in 130 (89.0%); a minority 16 (11.0%) did not have a psychiatric diagnosis. Following assessment, 94 patients (64.4%) met criteria for premenstrual dysphoric disorder and 67 (45.6%) had exacerbation of a psychiatric disorder.Clinical implicationsPatients presenting to this specialist service had complex psychiatric comorbidity; almost half presented with exacerbation of a psychiatric disorder.
Work More Tomorrow: Resolving Present Bias in Project Management
Authors: Shi Yun , Hall Nicholas G. , Cui Xiangyu 
Published: October 2022

Explaining and Resolving Delays in Projects Project management is responsible for 30% of the world’s economic activity, with an annual value of $27 trillion. Yet, despite half a century of research and the training of millions of project managers, many projects are delivered late. This is typically attributed to Parkinson’s Law, meaning the expansion of work to fill available time. However, in “Work More Tomorrow: Resolving Present Bias in Project Management,” Shi, Hall, and Cui identify and demonstrate the alternative explanation of time-inconsistent behavior, that is, present bias. Under present bias, a decision maker values immediate costs and rewards more than future ones. The authors show that this behavioral issue is responsible for procrastination by project workers and overall project delay. Borrowing concepts from popular employee savings schemes, they develop an incentive scheme that mitigates present bias and significantly enhances project performance, as measured by on-time frequency and expected project tardiness.
Pyoderma gangrenosum and dehydrated human amnion/chorion membrane: a potential tool for an orphan disease
Authors: Alston Dylan , Eggiman Evan , Forsyth R Allyn , Tettelbach William H 
Published: October 2022

Objective: Pyoderma gangrenosum (PG) is an often-misdiagnosed, painful, inflammatory and ulcerative skin disorder. It is an orphan disease, where standard wound treatments such as sharp surgical debridement are contraindicated. This retrospective case series sought to evaluate the application of dehydrated human amnion/chorion membrane (DHACM) as a skin substitute in cases that were refractory to a range of standard-of-care techniques. Method: This retrospective case series involved wounds which failed to close with standard escalating treatments, including anti-inflammatory and immunosuppressive therapies. Subjects were transitioned to DHACM and wound sizes were monitored until closure. Results: Wounds (n=5) for all three subjects had stalled with standard therapies for at least 2.5 months but responded quickly to routinely applied DHACM treatments, and closure was achieved in each case. Conclusion: This retrospective pilot case series examined the use of DHACM as an alternative wound treatment for PG patients failing standard therapies. DHACM treatments re-initiated the trajectory towards wound closure for each stalled PG ulcer. The results suggest a treatment algorithm starting with early recognition, wound closure via treatment escalation, and lastly a gradual reduction in treatment for durable closure. DHACM treatment should be formally evaluated as an adjunct to PG ulcers that have remained refractory to more commonly used immunomodulating therapies.
Expression of nucleolin, nucleophosmin, upstream binding transcription factor genes and propolis in wound models
Authors: Kaya Murat , Eroz Recep , Kabakliogli Murat 
Published: October 2022

Objective: Nucleolar proteins have important functions in the regulation of cell homeostasis and play a crucial role in sensing various types of stress, such as genotoxic stress. Propolis has epithelial, analgesic, antibacterial, antifungal and antiviral effects. This study aimed to evaluate the gene expression levels of nucleolar proteins: nucleolin (NCL); nucleophosmin (NPM1); and upstream binding transcription factor (UBTF), as well as the benefits of propolis in wound healing. Method: This experimental study was conducted by creating clean and clean–contaminated wounds according to the Surgical Site Infection Guidelines, 2016. A total of seven animal groups were included in the study: control; laparotomy; anastomosis; fucidic acid with/without anastomosis; propolis with/without anastomosis Results: Statistically significant differences of levels of gene expression among the groups were detected for NCL (p=0.004), NPM1 (p=0.011) and UBTF (p=0.000). When the expression levels of the related genes and blood parameters are considered, the relationship between NCL, NPM1 and UBTF expression levels and blood parameters (NE, EO, NE(%), LY, LY(%), EO, EO(%), MO, MO(%), RBC, HB, HCT, MCV, MCHC, RDW, RDW(%), PLT, PDW and PCT) were statistically significant. Conclusion: The nucleolar proteins such as NCL, NPM1 and UBTF have important functions in cell viability and its maintenance under various condition such as stress and injury. Additionally, propolis has positive benefits in wound healing and in the prevention of wound infection. Our findings provide the first insights into the putative role of those proteins in wound healing.
Person‐centered, high‐quality care from a distance: A qualitative study of patient experiences of TelAbortion, a model for direct‐to‐patient medication abortion by mail in the United States
Authors: Kerestes Courtney , Delafield Rebecca , Elia Jennifer , Shochet Tara , Kaneshiro Bliss , Soon Reni 
Published: October 2022

AbstractContextDirect‐to‐patient telemedicine abortion allows people to receive mifepristone and misoprostol for medication abortion in their home without requiring an in‐person visit with a healthcare provider. This method has high efficacy and safety, but less is known about the person‐centered quality of care provided with telemedicine.MethodsWe interviewed 45 participants from the TelAbortion study of direct‐to‐patient telemedicine abortion in the United States from January to July 2020. Semi‐structured qualitative interviews queried their choices, barriers to care, expectations for care, actual abortion experience, and suggestions for improvement. We developed a codebook through an iterative, inductive process and performed content and thematic analyses.ResultsThe experience of direct‐to‐patient telemedicine abortion met the person‐centered domains of dignity, autonomy, privacy, communication, social support, supportive care, trust, and environment. Four themes relate to the person‐centered framework for reproductive health equity: (1) Participants felt well‐supported and safe with TelAbortion; (2) Participants had autonomy in their care which led to feelings of empowerment; (3) TelAbortion exceeded expectations; and (4) Challenges arose when interfacing with the healthcare system outside of TelAbortion. Participants perceived abortion stigma which often led them to avoid traditional care and experienced enacted stigma during encounters with non‐study healthcare workers.ConclusionTelAbortion is a high quality, person‐centered care model that can empower patients seeking care in an increasingly challenging abortion context.
Long-term glucose-lowering effect of intermittently scanned continuous glucose monitoring for type 1 diabetes patients in poor glycaemic control from Region North Denmark: An observational real-world cohort study
Authors: Jensen Morten Hasselstrøm , Cichosz Simon Lebech , Gustenhoff Peter , Nikontovic Amar , Hejlesen Ole , Vestergaard Peter 
Published: October 2022

Background
Lowering glucose levels is a complex task for patients with type 1 diabetes, and they often lack contact with health care professionals. Intermittently scanned continuous glucose monitoring (isCGM) has the potential to aid them with blood glucose management at home. The aim of this study was to investigate the long-term effect of isCGM on HbA1c in type 1 diabetes patients with poor glycaemic control in a region-wide real-world setting.

Methods
All patients with type 1 diabetes receiving an isCGM due to poor glycaemic control (≥70 mmol/mol [≥8.6%]) in the period of 2020–21 in Region North Denmark (“T1D-CGM”) were compared with all type 1 diabetes patients without isCGM (“T1D-NOCGM”) in the same period. A multiple linear regression model adjusted for age, sex, diabetes duration and use of continuous subcutaneous insulin infusion was constructed to estimate the difference in change from baseline HbA1c between the two groups and within subgroups of T1D-CGM.

Results
A total of 2,527 patients (T1D-CGM: 897; T1D-NOCGM: 1,630) were included in the study. The estimated adjusted difference in change from baseline HbA1c between T1D-CGM vs T1D-NOCGM was -5.68 mmol/mol (95% CI: (-6.69 to -4.67 mmol/mol; p<0.0001)). Older patients using isCGM dropped less in HbA1c.

Conclusions
Our results indicate that patients with type 1 diabetes in poor glycaemic control from Region North Denmark in general benefit from using isCGM with a sustained 24-month improvement in HbA1c, but the effect on HbA1c may be less pronounced for older patients.
Frequency and patient attributes associated with emergency department visits after discharge: Retrospective cohort study
Authors: Salgado Rita , Moita Bruno , Lopes Sílvia 
Published: October 2022

Background
The utilization of emergency department (ED) during the post-discharge period may provide relevant insights to reduce fragmentation of care, particularly in a context of general intense use. We aimed to describe frequency and patient attributes associated with emergency department (ED) visits within 30 days of inpatient discharge in a Portuguese health region–Algarve.

Methods
Secondary data on inpatient and emergency care, for adult patients discharged in 2016. To analyse the association between outcome–ED visit within 30 days of discharge–and selected variables (admission type and groups of or individual illnesses/conditions), we used age- and sex-adjusted odds ratios (aOR). We included all adult patients (aged ≥18 years) discharged during 2016 from the region’s public hospital inpatient departments. The period for ED visits also included January 2017.

Results
For 21,744 adults discharged in 2016 (mean age: 58 years; 60% female), 23 percent visited ED at least once within 30 days of discharge. Seventy-five percent of those visits were triaged with high clinical priority. Patients with more comorbidities or specific groups of illnesses/conditions had a significant increased risk of returning ED (aOR and 95% confidence intervals–endocrine: 1.566; 1.256–1.951; mental illness: 1.421; 1.180–1.713; respiratory: 1.308; 1.136–1.505).

Conclusion
Patients returned ED after inpatient discharge frequently and for severe reasons. Patients with more comorbidities or specific groups of illnesses/conditions (endocrine, mental illness or respiratory) had an increased risk of returning ED, so these groups may be prioritized in further research and health system initiatives to improve care before and after discharge.
Noninvasive evaluation of the hemodynamic status in patients after heart transplantation or left ventricular assist device implantation
Authors: Roth Sebastian , Fox Henrik , M’Pembele René , Morshuis Michiel , Lurati Buse Giovanna , Hollmann Markus W. , Huhn Ragnar , Bitter Thomas 
Published: October 2022

Introduction
Hemodynamic assessment is crucial after heart transplantation (HTX) or left ventricular assist device (LVAD) implantation. Gold-standard is invasive assessment via thermodilution (TD). Noninvasive pulse contour analysis (NPCA) is a new technology that is supposed to determine hemodynamics completely noninvasive. We aimed to validate this technology in HTX and LVAD patients and conducted a prospective single-center cohort study.

Methods
Patients after HTX or LVAD implantation underwent right heart catheterization including TD. NPCA using the CNAP Monitor (V.5.2.14; CNSystems Medizintechnik AG, Graz, Austria) was performed simultaneously. Three TD measurements were compared with simultaneous NPCA measurements for hemodynamic assessment. To describe the agreement between TD and NPCA, Bland–Altman analysis was done.

Results
In total, 28 patients were prospectively enrolled (HTX: n = 10, LVAD: n = 18). Bland-Altman analysis revealed a mean bias of +1.05 l/min (limits of agreement ± 4.09 l/min, percentage error 62.1%) for cardiac output (CO). In LVAD patients, no adequate NPCA signal could be obtained. In 5 patients (27.8%), any NPCA signal could be detected, but was considered as low signal quality.

Conclusion
In conclusion, according to our limited data in a small cohort of HTX and LVAD patients, NPCA using the CNAP Monitor seems not to be suitable for noninvasive evaluation of the hemodynamic status.
First record of Selaginella kraussiana (Kunze) A. Braun in Western Ukraine (Eastern Europe)
Authors: Shalimov Alexander P. 
Published: October 2022

Based on examination of herbarium specimen that was previously misidentified as Selaginella helvetica (L.) Spring, we report the first voucher-based record of S. kraussiana (Kunze) A. Braun from the eastern Carpathian Mountains in West Ukraine. A morphological comparison of S. kraussiana with S. helvetica and S. selaginoides occurring in this region is given. Selaginella kraussiana differs from them in habit, vegetative leaves and strobili structure.