bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mediators, Moderators, and Covariates: Matching Analysis Approach for Improved Precision in Cognitive-Communication Rehabilitation Research
Authors: Morrow Emily L. , Duff Melissa C. , Mayberry Lindsay S. 
Published: October 2022

Purpose:
The dual goals of this tutorial are (a) to increase awareness and use of mediation and moderation models in cognitive-communication rehabilitation research by describing options, benefits, and attainable analytic approaches for researchers with limited resources and sample sizes and (b) to describe how these findings may be interpreted for clinicians consuming research to inform clinical care.

Method:
We highlight key insights from the social sciences literature pointing to the risks of common approaches to linear modeling, which may slow progress in clinical–translational research and reduce the clinical utility of our work. We discuss the potential of mediation and moderation analyses to reduce the research-to-practice gap and describe how researchers may begin to implement these models, even in smaller sample sizes. We discuss how these preliminary analyses can help focus resources for larger trials to fully encapsulate the heterogeneity of individuals with cognitive-communication disorders.

Results:
In rehabilitation research, we study groups, but we use the findings from those studies to treat individuals. The most functional clinical research is about more than establishing only whether a given effect exists for an “average person” in the group of interest. It is critical to understand the active ingredients and mechanisms of action by which a given treatment works (mediation) and to know which circumstances, contexts, or individual characteristics might make that treatment most beneficial (moderation).

Conclusions:
Increased adoption of mediation and moderation approaches, executed in appropriate steps, could accelerate progress in cognitive-communication rehabilitation research and lead to the development of targeted treatments that work for more clients. In a field that has made limited progress in developing successful interventions for the last several decades, it is critical that we harness new approaches to advance clinical–translational research results for complex, heterogeneous groups with cognitive-communication disorders.
Acoustic and Kinematic Assessment of Motor Speech Impairment in Patients With Suspected Four-Repeat Tauopathies
Authors: Cordella Claire , Gutz Sarah E. , Eshghi Marziye , Stipancic Kaila L. , Schliep Megan , Dickerson Bradford C. , Green Jordan R. 
Published: October 2022

Purpose:
The aim of this study was to use acoustic and kinematic speech measures to characterize type of motor speech impairment—apraxia of speech (AOS) versus dysarthria—in individuals with four-repeat tauopathy (4RT)–associated syndromes, including nonfluent variant primary progressive aphasia (nfvPPA), primary progressive AOS (PPAOS), corticobasal syndrome (CBS), and progressive supranuclear palsy syndrome (PSPs).

Method:
Twenty patient participants were recruited and stratified into two groups: (a) a motor-speech–impaired group of individuals with nfvPPA, PPAOS, CBS, or PSPs and suspected 4RT pathology (“MSI+”) and (b) a non–motor-speech-impaired group of individuals with logopenic variant primary progressive aphasia (“MSI−”). Ten healthy, age-matched controls also participated in the study. Participants completed a battery of speech tasks, and 15 acoustic and kinematic speech measures were derived. Quantitative speech measures were grouped into feature categories (“AOS features,” “dysarthria features,” “shared features”). In addition to quantitative speech measures, two certified speech-language pathologists made independent, blinded auditory-perceptual ratings of motor speech impairment. A principal component analysis (PCA) was conducted to investigate the relative contributions of quantitative features.

Results:
Quantitative speech measures were generally concordant with independent clinician ratings of motor speech impairment severity. Hypothesis-driven groupings of quantitative measures differentiated predominantly apraxic from predominantly dysarthric presentations within the MSI+ group. PCA results provided additional evidence for differential profiles of motor speech impairment in the MSI+ group; heterogeneity across individuals is explained in large part by varying levels of overall severity—captured by the shared feature variable group—and degree of apraxia severity, as measured by the AOS feature variable group.

Conclusions:
Quantitative features reveal heterogeneity of MSI in the 4RT group in terms of both overall severity and subtype of MSI. Results suggest the potential for acoustic and kinematic speech assessment methods to inform characterization of motor speech impairment in 4RT-associated syndromes.

Supplemental Material:

https://doi.org/10.23641/asha.21401778
Dissemination Research in Communication Sciences and Disorders: A Tutorial
Authors: Feuerstein Julie L. , Douglas Natalie F. , Olswang Lesley B. 
Published: October 2022

Purpose:
The purpose of this tutorial is threefold: (a) to bring attention to the role and value of dissemination research in communication sciences and disorders (CSD), (b) to introduce a model that can be used to guide dissemination research, and (c) to demonstrate strategic steps toward generating research questions and planning methods for dissemination research using an example from the authors' work.

Method:
This tutorial begins with a discussion of the role of dissemination in clinical research, with emphasis on differentiating the unique value of dissemination within the broader context of dissemination and implementation (D&I) research. The tutorial next presents a model of dissemination from the extant literature and describes how this model can be applied in CSD using examples from the authors' respective programs of clinical research. This is followed by an example that illustrates how the model can be used to determine research questions and guide the development of methods. Finally, the tutorial ends by discussing the potential impact of dissemination research for advancing efforts in CSD for closing the research-to-practice gap.

Conclusions:
Dissemination research is an often overlooked but critical component of D&I efforts. When approached systematically and rigorously, dissemination can make meaningful contributions to clinical research in CSD.
Harmonic resonance analysis in high‐renewable‐energy‐penetrated power systems considering frequency coupling
Authors: Wang Yang , Chen Haimeng , Gao Bo , Xiao Xianyong , Torquato Ricardo , Trindade Fernanda C. L. 
Published: October 2022

AbstractRenewable energy is a key solution to address the challenges of energy shortages and climate change. Consequently, high‐renewable‐energy‐penetrated power systems (HREPPS) have become a popular trend. This has led to the increasing use of voltage‐source converters (VSCs) as renewable‐energy interfaces. Meanwhile, other VSC‐based applications such as flexible alternating current transmission systems (FACTS) are used for supporting the energy conversion of renewable energy. With the large integration of VSC‐interfaced devices, there is a rising concern regarding their impact on the harmonic resonance of power systems. In this study, a new harmonically coupled impedance model is proposed to inspect the harmonic resonance caused by VSC‐interfaced devices in HREPPS. The model is derived based on the penetration of a multifrequency harmonic, enabling it to fully reveal the frequency coupling effect in the system. Research has shown that frequency coupling plays an important role in harmonic resonance analysis. The correctness of the proposed harmonic impedance model and its effectiveness on harmonic resonance analysis were verified using time‐domain simulations of a real‐life photovoltaic integrated system.
Molecular Docking Study of Isoxazole Indole Derivatives (B2A2 Series)
as Promising Selective Estrogen Receptor Modulators & Anticancer
Drugs
Authors: Iyer Jayashree Monikanta , Khare Aradhana , Pandey Jaya , Yadav Manish 
Published: October 2022

AbstractA series of 7 compounds with isoxazole – indole –
γ-resorcylic acid scaffold, segregated into B2 & A2 series,
wherein, B2 comprises Compounds: 13, 14, 15 & 16 and A2 comprises
Compounds: 10, 11 & 12, on the basis of the variable substituents at the
indole, resorcinol and isoxazole end of the scaffold as in Figure: 1, were
designed and docked with human estrogen receptor: 1ERRα. The Binding
affinity (BA) and the interacting amino acids compared with reference selective
estrogen receptor modulators (SERM’s) such as Raloxifene, Estradiol,
Bazedoxifene, Bisphenol, Genistein, Daidzein, Ormiloxifene, Tamoxifen,
6-hydroxy-naphthalen-2yl-benzo(D)-isoxazol-6-ol(1) using PyRx software and their
ADME properties predicted with SWISS ADME online tool. Significant similarities
and minor differences in the binding pattern between the key interacting
aminoacids such as Arg 394, Glu 353, Asp 351, Leu 346, Leu 525, Trp 383, Phe
404, Ala 350, Leu 387, Met 421 responsible for ER agonist/antagonist
affinity found in the binding cavity of a 1 Errα -Bazedoxifene/1
Errα -raloxifene/1 Errα -estradiol docked complex AND 1
Errα -isoxazole-indole- resorcinol docked complex indicate their
promising potential to serve as potent ER agonists in bone or ER antagonists
against breast cancer and other cancer diseases. The Compounds with highest BA
is of the order: BA (A1series)>B1series>/<BA(A2
series)>/=BA (B2 series) exceptions: compounds: 4, 5 of
B1 series & compound:13 of B2 series with identical and least BA
values.BA(6)=BA(8)>BA(7)>BA(2)>BA(9)=BA(1)>BA(12)>BA(10)=BA(15)=BA(11)=BA(3)>BA(14)=BA(16)>BA(4)=BA(5)=BA(13).
Nontraumatic Intracranial Epidural Hematoma: Systematic Review of the Literature
Authors: Souza Joilson Francisco de , Medeiros Luiz Eduardo Dantas Cerqueira , Pereira Carlos Umberto 
Published: October 2022

Abstract
Introduction Epidural hematoma (EDH) is generally a direct sequela of head injury. Spontaneous EDH is rarely described in the literature. Spontaneous EDH can be caused by infections of adjacent regions, vascular malformations of the dura mater, metastases to the bone skull, and disorders of blood coagulation. The preferred treatment is surgical. The prognosis is directly related to the size, location, and Glasgow Coma Scale score on admission and the underlying disease.
Methods A systematic literature review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We performed the search in the PubMed/MEDLINE, Embase, and Scopus databases. Abstracts and articles were screened according to our inclusion and exclusion criteria.
Results The literature review yielded 1,156 records from the databases, of which a total of 164 full-text articles were included in the final synthesis, plus 22 additional relevant studies. A total of 89 case report studies were included, providing 95 unique patients. There was a predominance of coagulopathies as the main etiology of spontaneous EDH. A total of 45.3% of the patients presented lesions in > 1 brain lobe. The frontal lobe was the most prevalent location of EDH. The most used neuroimaging exam was computed tomography (CT). Surgical intervention was the most common treatment performed. A total of 24.2% of the patients died.
Conclusion Nontraumatic EDH represents an uncommon manifestation of several pathologies. Clinical investigation should be aware of such a possibility. Healthcare professionals should value the physical examination and clinical history of the patient. Given the scarcity of information on the pathogenesis of spontaneous EDH, further studies are needed to better define intervention strategies and therapies for these patients.
Phenotypic causal networks between boar taint compounds measured in biopsies and carcasses
Authors: Botelho Margareth Evangelista , Lopes Marcos Soares , Mathur Pramod K. , Knol Egbert F. , Marques Daniele B. D. , Lopes Paulo Sávio , Silva Fabyano Fonseca e , Guimarães Simone Eliza Facioni , Veroneze Renata 
Published: October 2022

Context Boar taint compounds (androstenone, skatole and indole) can be measured in pig carcasses, after slaughter or, alternatively, in biopsies of subcutaneous adipose tissue from selected living pigs. Measuring these compounds via biopsy enables data collection in selected animals and high standardisation regarding tissue-collection procedures for phenotyping. Because different analytical methods can be used to measure boar taint compounds, it is important to better understand the relationship between boar taint compounds measured in biopsies and in carcasses. Aims This research aimed to identify the causal relationship and causal effects among boar taint compounds (androstenone, skatole and indole) measured in pig adipose tissue from carcasses and biopsies. Methods The concentrations of androstenone (AC), skatole (SC) and indole (IC) measured in adipose tissue from pig carcasses and the concentrations of androstenone (AB), skatole (SB) and indole (IB) measured in biopsies were used to fit a multi-trait Structural Equation Model (SEM) considering causal network graphs obtained via inductive causation algorithm with or without a priori information. Models were compared using the deviance information criterion (DIC). Key results The best DIC was obtained in a model with a causal structure built using a priori information; however, this model was considered inappropriate, because it returned several null genetic correlations among traits described as positively correlated. The best structure returned using only inductive causation algorithm was IB → SC ← AB ← AC ← SB: SC → IC, which was obtained with an 80–70% high-probability distribution interval. This model returned positive genetic correlations and improved goodness-of-fit compared with the multi-trait model in all cases. Several causal relationships among boar taint compounds in carcasses and biopsies were identified. Conclusion Boar taint compounds measured in biopsies have direct effects on boar taint compounds measured in carcasses. Implications Knowledge concerning the causal structure of boar taint compounds may be used in breeding programs, helping in the formulation of selection indexes and improving the ability for prediction and selection of this complex trait (boar taint).
Characterising fish habitat use of fringing oyster reefs using acoustic imaging
Authors: Dunn Robert P. , Kimball Matthew E. , O’Brien Caitlin G. , Adams Nathan T. 
Published: October 2022

Context Oysters provide structured habitat along coastal margins, but owing to the high turbidity of many estuaries, characterising the faunal communities that utilise oyster reefs typically requires direct capture, which is potentially lethal or destructive. Acoustic imaging sonar can non-destructively sample the abundance and size of swimming organisms (nekton), but collection of data from acoustic imaging files requires substantial processing time following field sampling. Aims We compared five alternate data examination protocols that could be applied to acoustic imaging files from intertidal oyster reefs and identified a protocol (analysing randomly chosen 3 of 5 min of imagery recordings) that reduces parameter estimation bias and processing time. Methods To demonstrate the utility of this protocol, we investigated diel differences in fish use of fringing oyster reefs. Key results During day-time and night-time sampling, we respectively recorded 4535 and 1924 fish across a size range of 1–52 cm. We found no difference between day and night in relative abundance, mean size, or size-spectra of the fish community inhabiting reefs. Conclusions and implications Active acoustic imaging can be an effective, non-destructive method to characterise faunal communities in shallow, turbid habitats and can be used to test hypotheses regarding the ecology of these ecosystems.
High sensitivity concave-shaped photonic crystal fiber sensor based on surface plasmon resonance
Authors: Du Zhenhua , Liu Huilong , Xia Jing , Lü Yanfei 
Published: October 2022

Abstract
A novel concave-shaped photonic crystal fiber sensor with double loss peaks based on surface plasmon resonance is proposed, whose properties are investigated by the finite element method. Gold can be utilized to generate excitation between the core mode and surface plasmon polariton mode. The simulation results indicate that in the wavelength range of 1.2 to 2.2 μm, the proposed sensor could detect the refractive index (RI) in the range of 1.18–1.30, the wavelength sensitivity of the primary loss peak could reach up to 18 000 nm/RIU and the corresponding resolution is 5.56 × 10−6 RIU in the RI range from 1.26 to 1.27. In addition, the double loss peaks could improve the detection accuracy, and the trough wavelength variation range is small, indicating that the proposed sensor is relatively stable, which improves the practicability of the sensor. This work could have a wide application value in the detection of medical testing, biomolecules, and organic chemistry.
A new method of layered superposition reconstruction modeling on grinding-shot peening surfaces
Authors: Tang Jinyuan , Chen Jiling , Yang Duo , Li Lin , Zhao Jiuyue , Guo Minzhi 
Published: October 2022

Abstract
Shot peening for semi-finished or finished parts is a high-performance precision manufacturing process, and the final micro-surface morphology has layered superposition features, that is, the original surface features and shot peening features coexist on the part surface. The existing layered superposition theory is based on the idea that the surface is superimposed under different baselines, but it cannot characterize the two-process surface where the characteristic baseline cannot be separated after shot peening. To solve this problem, a new layered surface superposition modeling method is proposed in this paper with the grinding-shot peening surface as the research object. In this method, the main texture features of the grinding surface are extracted by B-spline surface fitting, and the spatial distribution of craters in the shot peening surface is adjusted by this texture feature. The initial profile of the grinding-shot peening surface is constructed according to the Pawlus superposition theory, and its height parameters are adjusted by the time-frequency iteration method. In this paper, the modeling method is verified by the measured grinding-shot peening surfaces with a coverage of 100% and 200%. The results show that this method can not only ensure the uniformity of crater texture on the reconstructed surface, but also ensure that the maximum error of spatial parameters is less than 2%. Moreover, the symmetrical autocorrelation functions of the reconstructed surface are consistent with the characteristics of the measured surface.
Achievement of virologic suppression with HIV antiretroviral therapy in a patient also taking multiple daily cation supplement doses: A case report and review of the literature
Authors: Buscemi Lindsey , Mossholder Benjamin 
Published: October 2022

AbstractPurposeTo describe a case report of antiretroviral regimen selection, with considerations for drug-supplement interactions, for a patient living with HIV with complicated nutrition needs.SummaryA 56-year-old white female with a history of sleeve gastrectomy was initiated on coformulated bictegravir/emtricitabine/tenofovir alafenamide for treatment of HIV infection. Her baseline HIV viral load was 139,790 RNA copies/mL, and the baseline CD4 cell count was 544 cells/mm3. The patient additionally had a nutritional supplement regimen of twice-daily calcium and twice-daily multivitamins with minerals following sleeve gastrectomy. Due to binding interactions between polyvalent cations and bictegravir and the potential impact on antiretroviral efficacy, construction of a daily medication schedule to avoid interactions between the antiretroviral regimen and the supplements while promoting optimal dosing of each supplement was necessary; however there is currently no guidance on twice-daily cation dosing with coadministered bictegravir and limited guidance on multivitamin coadministration in this context. A review of the available literature on bictegravir interactions and pharmacokinetic parameters was performed. A dose separation strategy was utilized to design a regimen that maximized separation of doses of supplements from doses of bictegravir/emtricitabine/tenofovir alafenamide while minimizing interaction potential. At follow-up 8 weeks after regimen initiation, the HIV viral load was undetectable (&lt;40 copies/mL) and the CD4 cell count had increased to 821 cells/mm3.ConclusionIntegrase strand transferase inhibitor interactions with polyvalent cations in nutritional supplements can be avoided or mitigated with attention to timing of each dose and optimizing separation strategies. This case report shows the potential for alleviating such interactions through optimal dose scheduling.
Capture of mammal excreta byNepenthesis an effective heterotrophic nutrition strategy
Authors: Cross Adam T , van der Ent Antony , Wickmann Miriam , Skates Laura M , Sumail Sukaibin , Gebauer Gerhard , Robinson Alastair 
Published: October 2022

AbstractBackground and aimsWhile isotopic enrichment of nitrogen (15N) and carbon (13C) is often used to determine whether carnivorous plant species capture and assimilate nutrients from supplemental sources such as invertebrate prey or mammal excreta (heterotrophic nutrition), little is known about how successful the different strategies deployed by carnivorous plants are at obtaining supplemental nutrition. The collection of mammalian faeces by Nepenthes (tropical pitcher plants) is the result of a highly specialized biological mutualism that results in heterotrophic nitrogen gain; however, it remains unknown how effective this strategy is in comparison to Nepenthes species not known to collect mammalian faeces.MethodsWe examined how isotopic enrichment varied in the diverse genus Nepenthes, among species producing pitchers for invertebrate capture and species exhibiting mutualisms for the collection of mammal excreta. Enrichment factors were calculated from δ15N and δ13C values from eight Nepenthes species and naturally occurring hybrids along with co-occurring reference (non-carnivorous) plants from three mountain massifs in Borneo: Mount Kinabalu, Mount Tambuyukon and Mount Trus Madi.ResultsAll Nepenthes examined, except N. edwardsiana, were significantly enriched in 15N compared to co-occurring non-carnivorous plants, and 15N enrichment was more than two-fold higher in species with adaptations for the collection of mammal excreta compared with other Nepenthes.ConclusionsThe collection of mammal faeces clearly represents a highly effective strategy for heterotrophic nitrogen gain in Nepenthes. Species with adaptations for capturing mammal excreta occur exclusively at high elevation (i.e. are typically summit-occurring) where previous studies suggest invertebrate prey are less abundant and less frequently captured. As such, we propose this strategy may maximize nutritional return by specializing towards ensuring the collection and retention of few but higher-value N sources in environments where invertebrate prey may be scarce.