bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of Excellent Learning at Elderly Pesantren of Nurul Iman in Karanganyar Regency
Authors: Naj'ma Dinar Bela Ayu , Bakri Syamsul 
Published: December 2022

This study purposes to (1) determine the implementation of al-Qur'an learning for the Elderly Pesantren Nurul Iman of Karanganyar, (2) describe the implementation of worship fiqih learning for the elderly, and (3) explain the process of character education for the Elderly Pesantren Nurul Iman of Karanganyar. This research was conducted in August 2020 – January 2021. The subjects in this study were all asatidz (teachers) and elderly students of Pesantren Nurul Iman in Karanganyar Regency. Meanwhile, the selected research informants were caregivers, asatidz, students, local government and pesantren education experts. This research applied qualitative methods and case studies.
The results reveal that: (1) The implementation of learning the Qur’an for the elderly at Pesantren Nurul Iman Karanganyar is carried out using the Iqro method and the tsaqifa method. Class grouping is based on the individual abilities of elderly students and does not use the average model as the class system in general. This shows that learning the Qur'an for the elderly needs to have attention in the abilities of each elderly student, so that the superior learning method is very relevant to use. (2) The implementation of worship fiqh learning for the elderly at Pesantren Nurul Iman Karanganyar is carried out with the bandongan model. To evaluate the success of learning fiqh of worship, a practicum method is used, namely the practice of fiqh of worship, especially the practice of pasolatan fiqh. With this mentoring model, the process of learning fiqh worship becomes effective, not only in fiqh knowledge but also in worship practices. (3) The process of character education for the elderly at the Elderly Pesantren of Nurul Iman Karanganyar is carried out through integrating character education in rituals and dzikr, sports and arts, in addition to character building through lectures delivered in each study activity. This shows that character education can be effective if it is carried out with affective activities not just cognitive.
The Influence of the Role of the School Committee on the Implementation of School-Based Management
Authors: Jumirin Jumirin , Murniati Ngurah Ayu Nyoman , Wuryandini Endang 
Published: December 2022

This study aims to determine the influence of the role of school committees on the implementation of school-based management (SBM) in private elementary schools in Pemalang district. The method used in this study is a descriptive method with a quantitative approach, namely research with quantitative data which is then processed and analyzed for conclusions. The first step before the research is taken is to conduct a theoretical study, then the following stages are carried out; first, compiling research instruments, secondly testing the validity and reliability of instruments, thirdly the process of data retrieval, fourth tabulation of data, data processing and interpretation of data, fifth drawing conclusions. The results showed that; first, The role of the school committee as a judge, supporter, mediator and controller of the implementation of SBM obtained a minimum score of 69 and a maximum score of 202 with a score range of 133. The data can be described as saying that out of 100 respondents who stated that the role of the school committee was good, 13 people were equivalent to 13%, stated that 37 people played a good role. 37%, stated that 39 people played a role equivalent to 3 9% stated that they played less role as many as 9 people equivalent to 9% and respondents who stated that they did not play a role as many as 2 people were equivalent to 2%. With a mean value of 149.27 and a mode value of 162, the value is included in the interval class 150 – 176 in the good/high category. The conclusion of this study is that the level of SBM implementation in Pemalang District Private Primary School is influenced by the level of role of the school committee. The higher the role of the school committee, the more the implementation of SBM will increase. Similarly, if the role of the school committee is low or lacks a role, then the level of implementation of SBM will also decrease.
Non-steroidal anti-inflammatory drug-induced anaphylaxis infrequent in 388 patients with mastocytosis: A two-center retrospective cohort study
Authors: Bonadonna Patrizia , Olivieri Francesco , Jarkvist Jesper , Nalin Francesca , Zanotti Roberta , Maclachlan Laura , Gülen Theo 
Published: December 2022

BackgroundAnaphylaxis is a well-known feature of mastocytosis, particularly in relation to hymenoptera venom stings. It is therefore hypothesized that mastocytosis patients may also be predisposed to severe hypersensitivity reactions to certain medications including non-steroidal anti-inflammatory drugs (NSAIDs). For this reason, these patients are usually discouraged from using these drugs. The current study aimed to determine the prevalence and evaluate the severity of NSAID-related hypersensitivity reactions among patients with mastocytosis.MethodsA retrospective study was conducted among a total of 388 (≥18 years old) consecutive patients from two independent European mastocytosis centers, in Sweden and Italy. Patients underwent a thorough allergy work-up where self-reported NSAID-hypersensitivity reactions were re-evaluated by an allergist in the first cohort (202 patients) and results were validated in the second cohort (186 patients).ResultsOverall frequency of NSAID-hypersensitivity was 11.3% in the total study cohort. Most patients reacted with cutaneous symptoms (89%), whereas severe hypersensitivity reactions were infrequent with only 11 patients (2.8%) experiencing anaphylaxis. All NSAID-related hypersensitivity reactions had occurred before mastocytosis was diagnosed. There was no difference between the groups regarding gender, baseline tryptase levels or presence of atopy, asthma/rhinitis.ConclusionOur study indicates an approximate 4-fold increased prevalence of NSAID hypersensitivity among mastocytosis patients compared to the general population. However, most NSAID reactions were limited to the skin as the prevalence of overall anaphylaxis was infrequent. Our results support that mastocytosis patients with a known tolerance to NSAIDs can continue using these medications without special precautions, whereas those with a prior reaction to NSAIDs should undergo thorough allergy work-up, including drug challenges.
The hybrid model of autoregressive integrated moving average and fuzzy time series Markov chain on long-memory data
Authors: Devianto Dodi , Ramadani Kiki , Maiyastri  , Asdi Yudiantri , Yollanda Mutia 
Published: December 2022

IntroductionThe price of crude oil as an essential commodity in the world economy shows a pattern and identifies the component factors that influence it in the short and long term. The long pattern of the price movement of crude oil is identified by a fractionally time series model where the accuracy can still be improved by making a hybrid residual model using a fuzzy time series approach.MethodsTime series data containing long-memory elements can be modified into a stationary model through the autoregressive fractional integrated moving average (ARFIMA). This fractional model can provide better accuracy on long-memory data than the classic autoregressive integrated moving average (ARIMA) model. The long-memory data are indicated by a high level of fluctuation and the autocorrelation value between lags that decreases slowly. However, a more accurate model is proposed as a hybridization time series model with fuzzy time series Markov chain (FTSMC).ResultsThe time series data collected from the monthly period of West Texas Intermediate (WTI) oil price as the standard for world oil prices for the 2003–2021 time period. The data of WTI oil price has a long-memory data pattern to be modeled fractionally, and subsequently their hybrids. The times series model of crude oil price is obtained as the new target model of hybrid ARIMA and ARFIMA with FTSMC, denoted as ARIMA-FTSMC and ARFIMA-FTSMC, respectively.DiscussionThe accuracy model measured by MAE, RMSE, and MAPE shows that the hybrid model of ARIMA-FTSMC has better performance than ARIMA and ARFIMA, but the hybrid model of ARFIMA-FTSMC provides the best accuracy compared to all models. The superiority of the hybrid time series model of ARFIMA-FTSMC on long-memory data provides an opportunity for the hybrid model as the best and more precise forecasting method.
Binding mechanism and SERS spectra of 5-fluorouracil on gold clusters
Authors: Si Nguyen Thanh , Nhat Pham Vu , Nguyen Minh Tho 
Published: December 2022

The adsorption behaviour of the 5-fluorouracil (5FU) on small gold clusters AuN with N = 6, 8, 20 was evaluated by means of density functional theory using the PBE-D3 functional in combination with a mixed basis set, i.e. cc-pVDZ-PP for gold atoms and cc-pVTZ for non-metal elements. The binding energies between 5FU and gold clusters were determined in the range of 16–24 and 11–19 kcal/mol in gas-phase and aqueous media, respectively. The corresponding Gibbs energies were found to be around -7 to -10 kcal/mol in vacum and sigificantly reduced to -1 to -6 kcal/mol in water solution, indicating that both the association and dissociation processes are likely spontaneous. An analysis on the charge density difference tends to confirm the existence of a charge transfer from the 5FU molecule to Au atoms. Analysis of the surface-enhanced Raman scattering (SERS) spectra of 5FU adsorbed on the Au surfaces shows that the stretching vibrations of N−H and C=O bonds play a major role in the SERS phenomenon. A mechanism for the drug releasing from the gold surfaces is also proposed. The process is triggered by either the low pH in cancerous tumors or the presence of cysteine residues in protein matrices.
Anti-hyperglycemic contours of Madhugrit are robustly translated in the Caenorhabditis elegans model of lipid accumulation by regulating oxidative stress and inflammatory response
Authors: Balkrishna Acharya , Gohel Vivek , Pathak Nishit , Tomer Meenu , Rawat Malini , Dev Rishabh , Varshney Anurag 
Published: December 2022

BackgroundThe prevalence of diabetes has considerably increased in recent years. In the long run, use of dual therapy of anti-diabetic agents becomes mandatory to attain euglycemia. Also, the incidences of diabetes-related co-morbidities have warranted the search for new therapeutic approaches for the management of the disease. Traditional herbo-mineral, anti-diabetic agents like Madhugrit are often prescribed to mitigate diabetes and related complications. The present study aimed to thoroughly characterize the pharmacological applications of Madhugrit.MethodsPhytometabolite characterization of Madhugrit was performed by ultra-high performance liquid chromatography. Evaluation of cell viability, α-amylase inhibition, glucose uptake, inflammation, and wound healing was performed by in vitro model systems using AR42J, L6, THP1, HaCaT cells, and reporter cell lines namely NF-κB, TNF-α, and IL-1β. The formation of advanced glycation end products was determined by cell-free assay. In addition, the therapeutic potential of Madhugrit was also analyzed in the in vivo Caenorhabditis elegans model system. Parameters like brood size, % curling, glucose and triglyceride accumulation, lipid deposition, ROS generation, and lipid peroxidation were determined under hyperglycemic conditions induced by the addition of supraphysiological glucose levels.ResultsMadhugrit treatment significantly reduced the α-amylase release, enhanced glucose uptake, decreased AGEs formation, reduced differentiation of monocyte to macrophage, lowered the pro-inflammatory cytokine release, and enhanced wound healing in the in vitro hyperglycemic (glucose; 25 mM) conditions. In C. elegans stimulated with 100 mM glucose, Madhugrit (30 µg/ml) treatment normalized brood size, reduced curling behavior, decreased accumulation of glucose, triglycerides, and lowered oxidative stress.ConclusionsMadhugrit showed multimodal approaches in combating hyperglycemia and related complications due to the presence of anti-diabetic, anti-inflammatory, anti-oxidant, wound healing, and lipid-lowering phytoconstituents in its arsenal. The study warrants the translational use of Madhugrit as an effective medicine for diabetes and associated co-morbidities.
Ovarian cancer subtypes based on the regulatory genes of RNA modifications: Novel prediction model of prognosis
Authors: Zheng Peixian , Li Na , Zhan Xianquan 
Published: December 2022

BackgroundOvarian cancer (OC) is a female reproductive system tumor. RNA modifications play key roles in gene expression regulation. The growing evidence demonstrates that RNA methylation is critical for various biological functions, and that its dysregulation is related to the progression of cancer in human.MethodOC samples were classified into different subtypes (Clusters 1 and 2) based on various RNA-modification regulatory genes (RRGs) in the process of RNA modifications (m1A, m6A, m6Am, m5C, m7G, ac4C, m3C, and Ψ) by nonnegative matrix factorization method (NMF). Based on differently expressed RRGs (DERRGs) between clusters, a pathologically specific RNA-modification regulatory gene signature was constructed with Lasso regression. Kaplan-Meier analysis and receiver operating characteristic (ROC) curves were used to evaluate the prognostic ability of the identified model. The correlations of clinicopathological features, immune subtypes, immune scores, immune cells, and tumor mutation burden (TMB) were also estimated between different NMF clusters and riskscore groups.ResultsIn this study, 59 RRGs in the process of RNA modifications (m1A, m6A, m6Am, m5C, m7G, ac4C, m3C, and Ψ) were obtained from TCGA database. These RRGs were interactional, and sample clusters based on these regulators were significantly correlated with survival rate, clinical characteristics (involving survival status and pathologic stage), drug sensibility, and immune microenvironment. Furthermore, Lasso regression based on these 21 DERRGs between clusters 1 and 2 constructed a four-DERRG signature (ALYREF, ZC3H13, WTAP, and METTL1). Based on this signature, 307 OC patients were classified into high- and low-risk groups based on median value of riskscores from lasso regression. This identified signature was significantly associated with overall survival, radiation therapy, age, clinical stage, cancer status, and immune cells (involving CD4+ memory resting T cells, plasma cells, and Macrophages M1) of ovarian cancer patients. Further, GSEA revealed that multiple biological behaviors were significantly enriched in different groups.ConclusionsOC patients were classified into two subtypes per these RRGs. This study identified four-DERRG signature (ALYREF, ZC3H13, WTAP, and METTL1) in OC, which was an independent prognostic model for patient stratification, prognostic evaluation, and prediction of response to immunotherapy in ovarian cancer by classifying OC patients into high- and low-risk groups.
Metformin Use Was Associated With Reduced Risk of Incidental Sjögren's Syndrome in Patients With Type 2 Diabetes: A Population-Based Cohort Study
Authors: Wang Cheng-You , Lai Jung-Nien , Liu Chin-Hsiu , Hu Kai-Chieh , Sheu Kai-Lun , Wei James Cheng-Chung 
Published: December 2022

Purpose:Previous studies have shown that metformin exhibits an anti-inflammatory effect and may decrease the risk of incidental diabetes. But the effect of metformin on incidental Sjögren's syndrome is unknown. The aim of the study was to examine the association between metformin exposure and Sjögren's syndrome in diabetic patients.Methods:The dataset in this retrospective cohort study was obtained from the National Health Insurance Research Database (2000–2013) in Taiwan. In total, 15,098 type 2 diabetic patients under metformin treatment and an equivalent number without metformin treatment matched for comparison were included. The primary endpoint was the incidence of Sjogren's syndrome. Univariate and multivariate Cox proportional hazards models were used for data analysis. A subgroup analysis and sensitivity test were also performed.Results:The incidence rate of Sjögren's syndrome in non-metformin controls was 40.83 per 100,000 person-years and 16.82 per 100,000 person-years in metformin users. The adjusted hazard ratio (aHR) in diabetic patients under metformin treatment was 0.46 (95% CI, 0.23 to 0.92). In subgroup analysis, men had a lower risk of developing Sjögren's syndrome than women [aHR = 0.15, 95% CI = (0.05, 0.41)]. After prescribing metformin to type 2 diabetic patients aged 60 years or more, those patients had a lower risk of developing Sjögren's syndrome [aHR = 0.34, 95% CI = (0.12, 0.96)].Conclusion:In this large population-based cohort study, metformin exposure was associated with a reduced risk of developing Sjögren's syndrome in type 2 diabetic patients.
The effects of intravenous tramadol vs. intravenous ketamine in the prevention of shivering during spinal anesthesia: A meta-analysis of randomized controlled trials
Authors: Fenta Efrem , Kibret Simegnew , Hunie Metages , Tamire Tadese , Fentie Yewlsew , Seid Shimelis , Teshome Diriba 
Published: December 2022

BackgroundShivering is a common complication after subarachnoid administration of local anesthetics. Intravenous ketamine and tramadol are widely available anti-shivering drugs, especially in developing settings. This meta-analysis aimed to compare the effects of intravenous ketamine vs. tramadol for post-spinal anesthesia shivering.Materials and methodsPubMed/MEDLINE, Web of Science, Cochrane Library, Embase, and Google Scholar databases were used to search for relevant articles for this study. Mean difference (MD) with 95% confidence interval (CI) was used to analyze continuous outcomes, and risk ratio (RR) with 95% CI to analyze categorical results. The heterogeneity of the included studies was assessed using the I2 test. We utilized Review Manager 5.4.1 to perform statistical analysis.ResultsThirteen studies involving 1,532 patients were included in this meta-analysis. Ketamine had comparable effects in preventing post-spinal anesthetics shivering [RR = 1.06; 95% CI (0.94, 1.20), P = 0.33, I2 = 77], and onset of shivering [MD = −0.10; 95%CI (– 2.68, 2.48), P = 0.94, I2 = 0%], lower incidences of nausea and vomiting [RR = 0.51; 95%CI (0.26, 0.99), P = 0.05, I2 = 67%], and lower incidences of bradycardia [RR = 0.16; 95%CI (0.05, 0.47), P = 0.001, I2 = 33%], higher incidence of hallucinations [RR = 12; 95%CI (1.58, 91.40), P = 0.02, I2 = 0%], and comparable effects regarding the incidences of hypotension [RR = 0.60; 95%CI (0.30, 1.21), P = 0.15, I2 = 54%] as compared to tramadol.ConclusionsIntravenous ketamine and tramadol are comparable in the prevention of post-spinal anesthetic shivering. Ketamine had a better outcome with less occurrences of nausea, vomiting, and bradycardia. However, ketamine was associated with higher incidences of hallucinations than tramadol.
Fertilization drives distinct biotic and abiotic factors in regulating functional groups of protists in a 5-year fertilization system
Authors: Zhang Siyu , Zhang Haifang , Liu Hongmei , Wang Hui , Xiu Weiming , Li Gang , Zhang Guilong , Zhou Zhongkai , Jiang Na , Zhang Hao , Zhao Jianning , Yang Dianlin 
Published: December 2022

IntroductionProtists play an important role in nutrient cycling, microbiome stability and soil fertility maintenance. However, the driving force of protistan functional groups remains poorly understood in agricultural ecosystems.MethodsWe investigated the impacts of fertilization regimes on the diversity, composition and functional groups of protists and further disentangled the effects of multiple factors shaping the community composition of functional groups in a 5-year fertilization regime (CK, no fertilization; M, organic fertilization; MNPK, combined inorganic and organic fertilization; NPK, inorganic fertilization).ResultsFertilization significantly changed the community composition of protists rather than diversity. The MNPK treatment significantly increased the relative abundance of phototrophs and decreased that of the parasites and consumers. Partial least squares path modeling indicated that fertilization indirectly regulated protistan consumers via changes in the P content, which affected the composition of consumers mainly by regulating fungal community composition. Soil moisture (SM) and available phosphorus (AP) were identified as the top predictors for the composition of parasites, and the composition of phototrophs was mainly affected by SM, indicating that parasites and phototrophs were more sensitive to abiotic factors in the fertilization system.DiscussionTaken together, our findings highlight that fertilization significantly affects the composition of functional groups of protists and their biotic or abiotic regulatory processes, which have implications for the potential changes in their ecosystem functions for soil management systems.
Selective vulnerability of the intermediate retinal capillary plexus precedes retinal ganglion cell loss in ocular hypertension
Authors: Pitale Priyamvada M. , Shen Guofu , Sigireddi Rohini R. , Polo-Prieto Maria , Park Yong H. , Gibson Solomon E. , Westenskow Peter D. , Channa Roomasa , Frankfort Benjamin J. 
Published: December 2022

Introduction: Glaucoma, a disease of retinal ganglion cell (RGC) injury and potentially devastating vision loss, is associated with both ocular hypertension (OHT) and reduced ocular blood flow. However, the relationship between OHT and retinal capillary architecture is not well understood. In this project, we studied microvasculature damage in mice exposed to mild levels of induced OHT.Methods: Mild OHT was induced with the microbead model for 2 weeks. At this time point, some retinas were immunostained with CD31 (endothelium), Collagen IV (basement membrane), and RBPMS (RGCs) for z-stack confocal microscopy. We processed these confocal images to distinguish the three retinal capillary plexi (superficial, intermediate, and deep). We manually counted RGC density, analyzed vascular complexity, and identified topographical and spatial vascular features of the retinal capillaries using a combination of novel manual and automated workflows. Other retinas were dissociated and immunopanned to isolate RGCs and amacrine cells (ACs) for hypoxia gene array analysis.Results: RGC counts were normal but there was decreased overall retinal capillary complexity. This reduced complexity could be explained by abnormalities in the intermediate retinal capillary plexus (IRCP) that spared the other plexi. Capillary junction density, vessel length, and vascular area were all significantly reduced, and the number of acellular capillaries was dramatically increased. ACs, which share a neurovascular unit (NVU) with the IRCP, displayed a marked increase in the relative expression of many hypoxia-related genes compared to RGCs from the same preparations.Discussion: We have discovered a rapidly occurring, IRCP-specific, OHT-induced vascular phenotype that precedes RGC loss. AC/IRCP NVU dysfunction may be a mechanistic link for early vascular remodeling in glaucoma.