bluuebunny/crossref_metadata_2025_split huggingface dataset:
ІНСТИТУЦІЙНІ ДЕТЕРМІНАНТИ КОНКУРЕНТНОЇ ПОЛІТИКИ НА РИНКУ ФІНАНСОВИХ ПОСЛУГ
Authors: УМАНЦІВ Юрій , ШКУРОПАДСЬКА Діана 
Published: December 2022

Проблематика інституційних детермінант конкурентної політики на ринку фінансових послуг являє собою актуальний і перспективний дослідницький напрям, важливий як у теоретичному контексті, так і в практичному вимірі. Обґрунтування напрямів реалізації конкурентної політики на ринку фінансових послуг є особливо актуальним у країнах з ринками, що формуються, до яких належить і Україна. Зроблено висновок, що протягом останніх років застосування регуляторних механізмів на ринку фінансових послуг стало основою цифрової трансформації підприємницької моделі його суб’єктів. Активізацію розвитку таких технологій обумовлено діями регуляторів, спрямованими на підвищення дієвості інструментів нагляду після фінансових криз і зростання витрат на дотримання нових нормативних вимог. Засадничими детермінантами досягнення належного рівня конкурентних відносин між суб’єктами ринку фінансових послуг є розроблення і реалізація адекватної та збалансованої конкурентної політики держави. В Україні створено законодавчу базу й сформовано організаційні засади для реалізації ефективної державної конкурентної політики, проте поглиблення ринкових перетворень постійно породжує нові проблеми у сфері конкурентної політики, які потребують удосконалених підходів до їх вирішення.
Дослідження інституційних детермінант конкурентної політики на ринку фінансових послуг дозволило визначити основні, серед яких зростання залежності від екзогенних чинників, недосконалість стандартів поширення інформації та її асиметрія, порушення прав споживачів, деформація норм і практик провадження підприємницької діяльності, низький рівень довіри до суб’єктів ринку, динамічний розвиток фінансових інновацій. Інституційне середовище детермінує особливості функціонування ринку фінансових послуг, при цьому розвиток національної економіки неможливий за умов його розбалансованості. Завдання вирішення ідентифікованих проблем покладається в першу чергу на державні інститути, водночас і споживачі фінансових послуг мають брати активну участь у здійсненні постійного моніторингу діяльності суб’єктів ринку.
Uso de bebidas alcoólicas entre estudantes adolescentes no município de Soure, Pará, Brasil
Authors: De Souza Samara Borges , Moreira Maria Paula Antunes Luz , Costa Franciane Ferreira , De Queiroz Jocilena Pamela Quadros , Silva-Oliveira Gláucia Caroline , Oliveira-Filho Aldemir B. 
Published: December 2022

Objetivos: Este estudo identificou prevalências e fatores associados ao uso de bebidas alcoólicas entre estudantes adolescentes no município de Soure, Pará, norte do Brasil. Materiais e métodos: Neste estudo transversal, 736 estudantes adolescentes, oriundos de escolas públicas de ensino médio, forneceram informações por meio de formulário estruturado. Os testes Qui-quadrado e Odds Ratio foram usados para identificar os fatores associados ao uso de bebidas alcoólicas. Resultados: No total, 376 (51,1%) adolescentes informaram ter usado bebida alcoólica na vida e outros 166 (22,6%) afirmaram ter usado frequentemente nos últimos 30 dias. Cerveja, cachaça e misturas de frutas com cachaça foram as bebidas alcoólicas utilizadas na última vez de consumo. O uso de drogas psicotrópicas pelos pais ou responsáveis e amigos (todos ou a maioria deles) foram os fatores associados ao uso na vida e nos últimos 30 dias, sendo idade > 16 anos também associado ao uso nos últimos 30 dias. Conclusões: As elevadas prevalências de uso de bebidas alcoólicas e a associação com uso de drogas psicotrópicas por pais e amigos indicam um cenário preocupante, no qual há necessidade urgente de ações para prevenção e controle de uso de drogas psicotrópicas em Soure.
Quinazoline alkylthio derivative targets norepinephrine and calcitonin gene-related peptide to improve behavior and radiographic score in the rat model of cervical vertigo
Authors: Qin Zifu , Sun Pingping , Lu Tong , Li Jianting 
Published: December 2022

The present study investigated the effect of quinazoline alkylthio derivative (QAD) on cervical vertigo in the rat model and explored the underlying mechanism. Treatment of the cervical vertigo rats with QAD led to a significant (P<0.05) improvement in balance beam score compared to the model group. Cervical vertigo-mediated reduction in CGRP level in rat plasma samples was effectively inhibited on treatment with QAD. Treatment with QAD led to a significant (P<0.05) reduction in cervical vertigo-induced increase in ET-1 and NE levels in rats. An increase in NO production by cervical vertigo induction showed a significant (P<0.05) decrease in rats by QAD treatment. The QAD treatment of the rats significantly (P<0.05) inhibited cervical vertigo-induced increase in radiographic score on day 56. The radiographic score in cervical vertigo rats was decreased to 0.42 on treatment with QAD compared to 8.2 in the model group. Therefore, QAD treatment of the cervical vertigo rats improves behavioral score and inhibits radiographic score. It upregulates CGRP expression and suppresses ET-1, NE and NO levels in a rat model of cervical vertigo. Thus, QAD can be used for the treatment of cervical vertigo however, further investigations are required to study the mechanism in detail.
Isolation, culture and, characterization of Cardiosphere-Derived Cells (CDCs)
Authors: Álvarez Verónica , Casado Javier García , Blázquez Rebeca , Marinaro Federica , de Pedro María de los Ángeles , Pulido María , Nieto Esther López 
Published: December 2022

Abstract
Cardiosphere-derived Cells (CDCs) can be isolated from cardiac tissues of pigs. The protocol begins with an enzymatic digestion followed by a pre-culture in a specific cell culture medium. Adherent cells from digested tissue are detached and seeded with the Cardiosphere Growing Medium (CGM). Under these conditions, cells clusters are formed and migrating cells are selected and seeded again to expand CDCs. Phenotypical, functional and molecular assays are necessary for the characterization of isolated cells. Phenotypic analysis is performed by flow cytometry to identify surface markers. For functional analysis, cells are in vitro differentiated using different culture media, then stained and observed by optical microscopy. Finally, PCR can be used to analyse the gene expression profile.This protocol is suitable for establishing a CDCs culture for multiples applications: in vitro assays, preclinical studies, “omics” analyses, etc.
Closed–loop Oxygen Control Improves Oxygenation in Paediatric Patients Under High–flow Nasal Oxygen––a randomised crossover study
Authors: Sandal Ozlem , Ceylan Gokhan , Topal Sevgi , Hepduman Pinar , Colak Mustafa , Novotni Dominik , Soydan Ekin , Karaarslan Utku , Schultz Marcus J. , Agin Hasan 
Published: December 2022

Abstract
Recently, high flow oxygen therapy (HFOT) is becoming more popular in the treatment of any kind of respiratory failure. Pediatric mechanical ventilation consensus conference (PEMVECC) guidelines suggest measuring oxygen saturation by pulse oximetry (SpO2) in all ventilated children and furthermore to measure partial arterial oxygen pressure (PaO2) in moderate‑to‑severe disease in order to prevent excessive use of oxygen while preventing hypoxemia and hyperoxemia. However, from a practical point of view, this may require frequent manual adjustments of the inspired oxygen, which might be unfeasible, especially in high-demand periods, such as the recent COVID19 pandemic. Moreover, the COVID19 pandemic has also highlighted the need for optimizing oxygen usage at the hospital level, since medical oxygen can become a scarce resource in high-demand periods, such as a pandemic. Two proof-of-concept studies showed that automatic oxygen titration (AOT) is feasible in patients receiving high flow nasal oxygen therapy (HFNT) in an exercise-induced desaturation model and in patients with mild acute hypoxemic respiratory failure. This study aims to compare the safety and efficacy of a closed- loop FiO2 controller with conventional manual control of FiO2 during HFOT of pediatric patients in a pediatric intensive care unit (PICU). The hypothesis of this study is: Close-loop FiO2 controller increases the time spent within clinically targeted SpO2 ranges and decreases the time spent outside clinical target SpO2 ranges as compared to manual oxygen control in PICU patients treated with HFOT. This study was registered to clinical trials with the registration number NCT05032365.
Cultivation, differentiation, and lentiviral transduction of human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons for studying human TAU
Authors: Buchholz Sarah , Bell-Simons Michael , Cakmak Cagla , Klimek Jennifer , Zempel Hans 
Published: December 2022

Abstract
TAU pathology is a major hallmark of many neurodegenerative diseases summarized under the term tauopathies. In most of these diseases, e.g., Alzheimer’s Disease, the neuronal axonal microtubule-binding TAU protein becomes mislocalized to the somatodendritic compartment. In human disease, this missorting of TAU is accompanied by an abnormally high phosphorylation state of the TAU protein, and several downstream pathological consequences (e.g. loss of microtubules, degradation of postsynaptic spines, impaired synaptic transmission, neuronal death). While some mechanisms of TAU sorting, missorting and associated pathologies have been addressed in rodent models, few studies have addressed human TAU in physiological disease-relevant human neurons. Suitable human-derived in vitro models are necessary. This protocol provides a simple step-by-step protocol for generating homogeneous cultures of cortical glutamatergic neurons using an engineered Ngn2 transgene carrying WTC11 iPSC line. We further demonstrate strategies to improve neuronal maturity, i.e., synapse formation, TAU isoform expression, and neuronal activity by co-culturing hiPSC-derived glutamatergic neurons with mouse-derived astrocytes. Finally, we explain a simple way for high-efficiency lentiviral transduction of hiPSC-derived neurons at almost all stages of differentiation.
Efficient Non-Linear Equalization Scheme for Performance Enhancement of MIMO-OFDM Communication Systems Using Walsh Transform
Authors: Ramadan Khaled 
Published: December 2022

Abstract
The Orthogonal Frequency Division Multiplexing (OFDM) scheme offers efficient spectrum use and simple frequency domain equalization. Instead of a bank of modulators or demodulators, the OFDM system can be implemented using the Inverse Fast Fourier Transform (IFFT) or FFT. The OFDM system can also be implemented using the Inverse Fast Walsh Hadamard Transform (IFWHT) or the Fast Walsh Hadamard Transform (FWHT). In this article, we use IFWHT and FWHT to implement the OFDM implementation. Following that, a suggestion for a Joint Low-Complexity Regularized Zero Forcing-Successive Interference Cancellation (JLCRZF-SIC) equalizer is made. With a low-complexity implementation, the suggested equalizer conducts both equalization and Carrier Frequency Offset (CFO) correction procedures. The simulation results reveal that the suggested equalizer plays a significant role in comparison to the traditional one.
Patients’ and healthcare professionals’ perceived facilitators and barriers for shared decision-making for frail and elderly patients in perioperative care: A scoping review
Authors: Vogel Amyn , Guinemer Camille , Fürstenau Daniel 
Published: December 2022

Abstract
BACKGROUND: Shared decision-making (SDM) in perioperative care, an organizational approach to instituting sharing of information and decision-making around surgery, aims at enabling patient-centric treatment and alignment of care to individual patient needs. Frail and elderly patients suffering from multiple health conditions and increased surgical vulnerability require individualized healthcare and may benefit. However, little is known about the facilitators and barriers to implementing SDM in perioperative care for the specific needs of frail and elderly patients.
Our objective is twofold: First, we aim at collecting and communicating facilitators and barriers. Second, we aim at collecting conceptual approaches and methods employed in determining and analyzing these facilitators and barriers.
METHODS: The search strategy focused on peer-reviewed studies. We employed a taxonomy which is based on the SPIDER framework and added the items general article information, stakeholder, barriers/facilitators, category, subcategory, and setting/contextual information. This taxonomy is based on preceding studies. The scoping review is reported under the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews. Based on the databases MEDLINE, Embase, CINAHL, and Web of Science, we identified and reviewed 13 original studies.
RESULTS: The major result is that patients want to be informed on their medical condition and procedures. The results further indicate that patients prefer sharing decisions over taking decisions on their own or physician induced decision-making. Communication barriers and asymmetric power relationships between patients and clinical healthcare professionals are barriers to SDM. Regarding the methodological approaches, the evaluation demonstrates that the selected articles are primarily concerned with the collection of determinants that enable or impede the implementation of SDM. These approaches lack employing a distinct theoretical framework for explaining these determinants. Second, the selected studies mainly used surveys and interviews, ethnographic studies are absent.
CONCLUSION: Diverging findings perceived by patients or clinical healthcare professionals were identified. These imply that SDM research related to elderly and frail patients should become more encompassing by employing research that incorporates theory-based qualitative analysis, and ethnographic studies of SDM consultations for understanding practices by patients and clinical healthcare professionals. Ethnographic studies are particularly relevant as these were not conducted.
REGISTRATION: https://osf.io/8fjnb/
Development and external validation of a clinical prediction model for predicting quality of recovery up to one week after surgery
Authors: Beek Stefan , Nieboer Daan , Klimek Markus , Stolker Robert Jan , Mijderwijk Hendrik-Jan 
Published: December 2022

Abstract
The Quality of Recovery Score-40 (QoR-40) has been increasingly used for assessing recovery after patients undergoing surgery. However, a prediction model estimating quality of recovery is lacking. The aim of the present study was to develop and externally validate a clinical prediction model that predicts quality of recovery up to one week after surgery. The modelling procedure consisted of two models of increasing complexity (basic and full model). To assess the internal validity of the developed model, bootstrapping (1000 times) was applied. At external validation, the model performance was evaluated according to measures for overall model performance (explained variance (R2)) and calibration (calibration plot and slope). The full model consisted of age, sex, previous surgery, BMI, ASA classification, duration of surgery, HADS and preoperative QoR-40 score. At model development, the R2 of the full model was 0.24. At external validation the R2 dropped as expected. The calibration analysis showed that the QoR-40 predictions provided by the developed prediction models are reliable. The presented models can be used as a starting point for future updating in prediction studies, to implement them clinically in the future.
Feasibility and acceptability of developing a culturally and linguistically congruent digital storytelling intervention among Vietnamese and Korean American mothers of HPV-vaccinated children
Authors: Kim Wonsun (Sunny) , Chen Angela Chia-Chen , Ou Lihong , Larkey Linda , Todd Michael , Han Yooro 
Published: December 2022

Abstract
Background
The high morbidity, mortality, and economic burden attributed to cancer-causing HPV call for researchers to address this public health concern through human papillomavirus (HPV) vaccination. Disparities of HPV-associated cancers in Vietnamese and Korean Americans (VA, KA) exist, yet their vaccination rates remain low. Evidence points to the importance of developing culturally and linguistically congruent interventions to improve their HPV vaccination rates. This paper aimed to assess feasibility acceptability and the process and mothers’ lived experience of creating and sharing personal stories.
Methods
Through community partner, social media and snowballing, we recruited two VA and six KA mothers (mean age = 41.4 years old; SD = 5.8) who had children vaccinated against HPV. Three virtual digital storytelling (DST) workshops were conducted between July 2021 and January 2022. Our team supported mothers to develop their own stories, practice digital editing and helped with editing by combining written and oral narratives, photos/images, voiceover, and soundtrack. Mothers filled out online surveys before and after the workshop and provided feedback on each other’s story ideas and the workshop experience. We used descriptive statistics to summarize the quantitative data and constant comparative analysis to analyze qualitative data collected in the workshop and field notes.
Results
Eight digital stories were developed in the DST workshops. They were well accepted, shown in the mothers’ overall satisfaction and relevant indicators (i.e., would recommend it to others, would watch more stories and attend a similar workshop, it was worth their time and appropriate; mean = 4.6–4.8, range 1–5). They found the process rewarding and appreciated the opportunity to share their stories in group settings and learn from each other. Six themes (e.g., cultural perspectives to healthcare and HPV vaccination) emerged from the data reflected the mothers’ rich personal experiences, attitudes, and perceptions about their child’s HPV vaccination.
Conclusions
Our findings suggest that virtual DST workshop is a highly feasible and acceptable approach to engage VA and KA immigrant mothers in developing culturally and linguistically congruent interventions. Further research is needed to test the efficacy and effectiveness of the digital stories as an intervention for promoting HPV vaccination among these populations.
Development of a patient assessment to meet the needs of patients suffering from advanced non-oncological diseases – the KOPAL study
Authors: Marx Gabriella , Mallon Tina , Stanze Henrikje , Zimansky Manuel , Schneider Nils , Nauck Friedemann , Scherer Martin , Pohontsch Nadine 
Published: December 2022

Abstract
Background
To develop an aide memoire for patients diagnosed with advanced non-oncological chronic diseases, the KOPAL conversation guide, to foster interprofessional counselling between GPs and specialist palliative home care teams.
Methods
As part of the multi-centre, two-arm, cluster randomised controlled KOPAL study, the draft of the conversation guide was discussed and consented in three focus groups with 4 patients, 7 health care providers, and 5 stakeholders.
Results
The final version of the KOPAL conversation guide contains eight key topics: living with the illness, physical situation, emotional situation, personal situation, social situation, information and communication, control and autonomy, emergency management. Each topic refers to different general points, which are listed on top of the respective thematic section. The conversation should start by addressing the patient’s today’s well-being and end by asking for the patient’s main topic based on the discussed issues.
Conclusions
The KOPAL conversation guide is a broad evaluation and communication tool that covers potential palliative care (PC) needs of non-oncological patients and provides a basis for interprofessional case planning and counselling. Applying the KOPAL conversation guide may help to bridge the communicative gap between general and specialist PC professionals and between professionals and patients.
Contrast Enhanced Mammography in Breast Cancer Surveillance
Authors: Elder Kenneth , Matheson Julia , Nickson Carolyn , Box Georgia , Ellis Jennifer , Mou Arlene , Shadbolt Clair , Park Allan , Tay Jia , Rose Allison , Mann Gregory Bruce 
Published: December 2022

Abstract
Purpose: Women with a personal history of breast cancer or DCIS (PHBC) are at increased risk of either a local recurrence or a new primary breast cancer. Adjunctive screening ultrasound or MRI is often used to supplement mammography. Contrast enhanced mammography (CEM) is reported to have higher sensitivity than MG and ultrasound, and similar performance with better accessibility than MRI.
Methods: We introduced CEM as a routine single imaging modality for surveillance of those with PHBC. This report is of the first surveillance round outcomes comparing CEM with digital mammography.
Results: 73/1191 (6.1%) patients were recalled for further assessment. 35 (48%) were true positives (TP), with 26 invasive cancers and 9 cases of DCIS, while 38 (52%) were false positive (FP) with a positive predictive value (PPV) 47.9%. 32/73 were recalled due to findings on MG, while 41/73 were only recalled due to Contrast. 14/73 had ‘minimal signs’ with a lesion identifiable with knowledge of the Contrast finding while 27/73 were ‘contrast only’. 41% (17/41) of those recalled due to contrast were TP. Contrast-only TPs were found in those with low and high mammographic density (MD). Bilateral screening breast US reduced by 55% in the year after routine surveillance CEM was implemented.
Conclusion: Compared to MG, CEM as a single surveillance modality for those with PHBC has higher sensitivity and comparable specificity, identifying additional malignant lesions that appear to be clinically significant. Further investigation of interval cancer and subsequent round cancer detection rates is warranted.