bluuebunny/crossref_metadata_2025_split huggingface dataset:
Including Children with Autism Spectrum Disorder in mainstream Early Childhood Settings: What teachers do.
Authors: Higginson Raewyn 
Published: September 2022

Abstract
Autism Spectrum Disorder (ASD) is a label given to a neurological condition that causes people to act and think differently from neurotypical people. While there are New Zealand/Aotearoa studies reporting on children with ASD in more formal educational, compulsory settings, little is known about including children with ASD in mainstream early childhood settings. In this article the research focuses on investigating children with ASD who are included within three mainstream early childhood settings within one region of New Zealand/ Aotearoa, using case study methodology. The data collected included observations of teachers interacting with the child with ASD, semi-structured interviews with the key teacher, centre manager and the family/whānau of the child as well as collecting documents supporting the child within the centre. The findings indicate that all three ECE settings mostly included the child, while addressing some of their learning needs. However, it also highlighted the need for all teachers to have professional development when teaching children with ASD.
A Method of Identification of SARS-CoV-2 Variant Using NCBI BLAST-2 100% Homology Search with Specific Oligonucleotides Selected at the Deletion Boundaries of S, N, ORF7a, ORF8 and ORF1ab Proteins
Authors: CHAKRABORTY ASIT KUMAR 
Published: September 2022

Abstract
Genomic sequencing of many SARS-CoV-2 variants with higher transmission and immune-escape were reported due to point mutations and deletions. Thus, whether a newly sequenced SARS-CoV-2 belongs to Alpha, Beta, Gamma, Delta, or Omicron (BA.1, BA.2, BA.4 and BA.5) variants must be known. We multi-aligned the different Spike, ORF1ab and Nucleocapsid proteins of those corona virus variants and detected different lineage specific deletions and point mutations. Different COVID-19 sequences were aligned with CLUSTAL Omega software and oligonucleotides from deletion boundary were selected. BLAST search using those oligonucleotides clearly predicted the specific variant type with 100% homology and was very useful for new corona virus sequence characterization. Selection of sub-variants were done by oligonucleotides selected at the specific point mutation boundaries leading to amino acid change. COVID-19 variant status was not reported in most published corona virus sequences and this method would be very useful application to understand the nature of expected prognosis of corona virus infected patients in less technology-equipped countries.
Diagnostic, Prognostic, and Immunological Roles of CD177 in Cervical Cancer
Authors: Liao Wenxin , Li Wei , Li Yang , Liu Tingting , Wang Ying , Feng Dan , Shen Fujin 
Published: September 2022

Abstract
Background.
CD177, an indicator of prognosis in diverse cancers, is involved in the physiological processes of various tumor cells, and acts as an immune molecule with novel functions in cancer pathogenesis. However, the diagnostic, prognostic and immunological role of CD177 in cervical cancer remains unclear.
Methods.
Utilizing publicly available databases and integrating several bioinformatics analysis methods, we evaluated the expression level of CD177 in cervical cancer by GENT2, HPA and GEO databases. The Kaplan–Meier Plotter database, Xena Shiny and the constructed of a nomogram were clearly demonstrated its prognostic value for patients. Gene set enrichment analysis explored the relationship between CD177 and cervical cancer immune responses and immune cells infiltration level. In addition, we investigated the association between CD177 expression and stromalscore, immunescore, immune checkpoint and drug sensitivity by TCGA RNA-seq data.
Results.
CD177 was apparently expressed at low levels in cervical cancer and predicted a poor survival rate for patients. CD177 significantly activated immune-related signaling pathways and had a positive relationship with immune cell infiltration level. The high CD177 expression group possessed the high stromalscore and immunescore. CD177 had potential interactions with CTLA4, CD27, BLTA, CD200R1, CD80, NRP1, TNFRSF25, TIGIT, ICOS and TNFSF9 checkpoint markers. And CD177 expression was positively relevant with drug sensitivity for Lapatinib, Belinostat, ATRA, Gefitinib, Navitoclax and Tamoxifen.
Significance.
These findings may shed light on the vital role of CD177 in cervical cancer diagnosis, prognosis, and immunological function, and it may be a promising predictor and potential factor for cervical cancer patients.
Effect of Rapamycin Treatment in Human Seminoma TCam-2 Cells through Inhibition of G1-S Transition
Authors: Onel Tugce , Erdogan Cihan S. , Aru Basak , Yildirim Ecem , Demirel Gulderen Yanikkaya , Yaba Aylin 
Published: September 2022

Abstract
Introduction: Mammalian Target of Rapamycin (mTOR) is an important serine/threonine kinase that plays a critical role in several processes including cell cycle, protein synthesis and energy metabolism. Due to its multiple roles and general dysregulation in cancer, the mTOR pathway is an important target in cancer therapy. However, studies on mTOR activity in seminoma are limited. Therefore, our aim was to investigate the expression of mTOR signaling pathway proteins in the TCam-2 cell line after rapamycin treatment.
Methods: TCam-2 cells were treated with different concentrations of rapamycin (control (no rapamycin treatment), 4 nM, 20 nM, 100 nM, 500 nM and 1000 nM rapamycin) for 48 h and 72 h. mTOR, p-mTOR, P70S6K, p-P70S6K, proliferating cell nuclear antigen (PCNA) and Caspase-3 expression levels were analyzed by western blot. Apotosis and cell cycle were analyzed by flow cytometry.
Results: After 48 hours of rapamycin administration, mTOR activity was significantly decreased at 1000 nM (p<0.05). In addition, P70S6K acitivity significantly decreased in groups at all rapamycin concentrations (***p<0.001, ****p<0.0001). After 72 hours of rapamycin administration, mTOR pathway activity were significantly decreased at 100, 500 and 1000 nM rapamycin-treated groups (p<0.05). Moreover, P70S6K expression decreased in all treatment groups (****p<0.0001). Caspase-3 expression were similar in all groups. While PCNA expression tended to decrease at 48 h in a dose-dependent manner, this decrease was not significant. We detected decreased PCNA expression at 1000 nM rapamycin at 72 h (p<0.05). The rate of apoptosis increased especially at 1000 nM rapamycin at 72 hours (***p<0.001). On the other hand, according to the results of the cell cycle experiment, G1 phase arrest was detected at all rapamycin doses at 48 and 72 hours (***p<0.001).
Conclusion: our study indicated that 1000 nM rapamycin may inhibit TCam-2 seminoma cells growth by halting cell proliferation through inhibition of G1-S transition. Therefore we believe that the findings obtained will contribute to the development of new treatment approaches for seminoma patients in the future and in the process of restoring testicular functions and preserving fertility.
A new decision-marking model to improve the performance of technological innovation project
Authors: Chien Li-Chih , Liu Feng-Lang , Chang Ching-Ter 
Published: September 2022

Abstract
The promotion of technical and management capabilities is one of the important strategies in government policy to enhance the competitiveness of small and medium enterprises (SMEs). A serial of efficient and accurate decision-making models is then required to achieve this strategic goal. The construction machinery industry belongs to SMEs. It is also essential for infrastructure construction in Taiwan. This study aims to show the ways to improve the performance of SMEs in an uncertain environment. To deal with this issue, the Fuzzy Delphi method and fuzzy analytic hierarchy process (FAHP) are used to find key success factors (KSFs) of SMEs. TOPSIS method is used to find the best project leader for their projects. Also, the MCGP-U method is used to find the optimal resource allocations. In addition, the “plan-do-check-action cycle” is used to emphasize the importance of sustainable improvement. The contributions of the proposed model are as follows: (1) it considers multi-faceted of SMEs to avoid wrong decisions; (2) it can easily obtain the SEM’s KSFs to improve the performance of SMEs; and (3) the results of the study can be used to improve SEMs' managerial fitness and effectiveness.
Outcome of Primary Management of Scleral Rupture without Vitrectomy Jakarta Eye Trauma Study
Authors: Simanjuntak Gilbert W.S , Raju Biju , Simanjuntak Golda A.M , Natali Reinne 
Published: September 2022

Introduction:
To report the outcome of primary management of scleral rupture without vitrectomy.

Methods:
Descriptive retrospective study of primary surgical management of scleral rupture located anterior to the equator. Initial and final visual acuity (FVA, intra ocular pressure, type of injury (sharp/blunt/projectile), wound length, time interval between the incident and primary repair and cause of injury were recorded. Encircling scleral buckle was placed in case of scleral laceration reaching muscle insertion. Patients who had a follow up of 3 months after the primary repair were included in the study .

Results:
There were 41 patients out of 78 who had scleral rupture anterior to the equator. The average age was 21.27 + 9.73 years (range 3-50 years). Thirty-three (80.4%) were males and eight (19.6%) were females. Rupture was located superiorly) in 28 (68.3%) patients, and inferiorly in 13 (31.7%) patients. Eight patients underwent encircling buckle. The time interval from the injury till the primary repair less than 8 hours (p 0.000) and 8-24 hours (p 0.000) were associated significantly with FVA improvements. Initial VA correlated with FVA improvement significantly (p 0.001). Two patients with initial VA of LP became NLP, and they had a wound length 11 mm and 12 mm respectively.

Conclusion:
The primary management of scleral rupture anterior to the equator, without vitrectomy, improves VA significantly. Time interval less than 24 hours and shorter wound length correlated with significant improvement of final VA.
Features of Medical Care Providing to Patients with Digestive Diseases in the Krasnodar Region during the COVID-19 Pandemic
Authors: Korochanskaya N. V. , Durleshter V. M. , Gabriel S. A. , Kovalevskaya O. V. , Serikova S. N. , Basenko M. A. 
Published: September 2022

The aim of the study: optimization the medical care provision to patients with diseases of the digestive system (DD) in the Krasnodar Region during the COVID-19 pandemic.Material and methods. The analysis of the features of the DD course in the Krasnodar Region was carried out according to the data of form C 51 “Distribution of the dead by sex, age groups and causes of death” of the Territorial Federal State Statistics Service in the Krasnodar Region, as well as monitoring the quality of medical care for patients with DD for the period from 2019 to 2021 years.Results. During the COVID-19 pandemic, the routing of gastroenterological patients, dispensary observation and preventive measures have undergone some changes. In the structure of total mortality in the Krasnodar Region, mortality from DD was 21.6 % in 2020 and 4.0 % in 2021. The decrease in the growth of mortality rate, including from DD, in the second year of the pandemic is associated with the completed healthcare systems reformatting. The increase in hospital mortality in patients with gastric and duodenal ulcers, ulcerative colitis, and diverticular disease had a significant impact on mortality rates from DD. The decreasing number of hospitalizations was explained due to the conversion of a number of hospitals into hospitals for the treatment of patients with COVID-19. The hospitalization was mainly carried out for emergency indications and patients with a more severe course of the disease. The pandemic has increased the need for telemedicine: 378 tele-consultations on the gastroenterological profile was carried out in the Krasnodar Region in 2021.Conclusion. Healthcare system workload in the Krasnodar Region increased significantly during the coronavirus pandemic that required a number of structural adjustments. In recent times, the regional health care is returning to the planned mode of providing medical care.
Desordens orais potencialmente malignas: uma análise bibliométrica dos trabalhos apresentados na Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
Authors: Oliveira Cruz Ana Karoliny , Marques Barbosa Geanderson José , Viana Gabriel Toscano , Costa Úrsula , Firmino Ramon Targino , Silva e Farias Ilky Pollansky , Goes Gonzaga Amanda Katarinny 
Published: September 2022

Objetivo: as Desordens Orais Potencialmente Malignas (DOPMs) consistem em lesões e condições epiteliais que apresentam risco aumentado de malignidade. Nessa pesquisa, buscou-se identificar o perfil da produção científica brasileira sobre as DOPMs, a partir de uma análise bibliométrica dos trabalhos apresentados nas Reuniões da Sociedade Brasileira de Pesquisa Odontológica (SBPqO). Materiais e Métodos: foi realizado um estudo bibliométrico, em que foram analisados os anais das reuniões anuais da SBPqO realizadas entre 2015 a 2019. Incluiu-se resumos sobre DOPMs apresentados em qualquer categoria e as seguintes informações foram extraídas: ano, desenho do estudo, tipo de DOPM, unidade federativa, localização e instituição de ensino superior de origem. Os dados foram analisados por meio de estatística descritiva. Resultados: foram identificados 91 resumos. A maior parte foi publicada em 2015 (24,2%) e por autores do estado de São Paulo (22%). A leucoplasia foi a desordem mais frequente (36,2%), seguida pela queilite actínica (35,2%). A maioria dos estudos foi de autoria de pesquisadores das regiões Sudeste (29%) e Sul (28%). Em relação à instituição de ensino, grande parte (68,1%) foi proveniente de universidades públicas. O tipo de estudo mais frequente foi pesquisa laboratorial básica (57,1%). Discussão: os achados do estudo indicam que o número de pesquisas sobre as DOPMs apresentadas nas Reuniões da SBPqO ainda é reduzido, concentrados na região sudeste e nas universidades públicas. Conclusão: realizar novas pesquisas a respeito desse tema é muito importante, pois permite a descoberta de informações relevantes para a saúde dos indivíduos frente a essa neoplasia.
Pengaruh Pemanfaatan Teori Super Dalam Layanan Penempatan Dan Penyaluranterhadap Pengambilan Keputusan Karir Siswa
Authors: Zaleha Zaleha , Subhan Muhammad 
Published: September 2022

Career decision-making was an important step for high school students. In career decision-making should also be adapted to the capabilities of the students themselves. This research aimed at knowing the influence of utilization of Super theory on Placement and Distribution service toward student career decision-making at Vocational High School of Multi Mekanik Masmur Pekanbaru students. Quantitative method was used in this research with simple linear regression data analysis technique. The eleventh-grade students were the population of this research. Simple random sampling technique was used in this research. Questionnaire and documentation were the techniques of collecting the data. The requirements to use simple linear regression analysis were implemented. The results of this study there is the influence of variable X on variable Y can be seen by looking at the value of R Squere which is 0.157 which means that the variable X to the variable Y is 15.7%. In other words, the use of the Super theory in placement and channeling services has a 15.7% effect on career decision making for students of the Multi Mechanic Vocational High School of the Masmur Pekanbaru, and 84.3% was influenced by other factors. It was recommended to the next researchers to study about other variables, except the variable studied.
Konseling Individual Dengan Teknik Pemberian Nasehat Dalam Memecahkan Masalah Kedisiplinan Siswa
Authors: Wulandari Indri Yuli , Suhertina Suhertina 
Published: September 2022

This research aimed at knowing the use of giving advices technique by guiding and counseling teacher on individual counseling services to solve student discipline problems and the factors influencing the use of giving advices technique on individual counseling services as to solve student discipline problems and the characteristics of student who were not discipline. The subjects of the research were 1 guiding and counseling teacher, and 3 students often violating disciplines. The object of the research was the individual counseling by giving advices technique in solving student discipline problems. The supporting informant of this research was 1 homeroom teacher. This research was a qualitative research with a case study design. Interview, observation and documentation techniques were used for collecting the data. Qualitative descriptive were used for analyzing the data. The finding of this research showed that the use of giving advices technique by guiding and counseling teacher on individual counseling services was that a way to direct students not violate disciplines. Giving advices technique was used by guidance and counseling teacher for students often violating disciplines-- showing students both the better and worse behaviors. After giving advices, it was expected that students could make decisions for themselves, especially in solving discipline problems. The factors influencing the use of giving advices technique by guiding and counseling teacher on individual counseling services as to solve student discipline problems were caused by two factors--internal and external factors. Internal factors (from themselves) and from teacher him/herself, the teacher was not a graduate of guidance and counseling education. While the external factors ( family invironment), and characteristics of student who wer not discipline were such as student often come late, sleep in classroom, come late, doing homework at school and lack attention to the teacher explanation.
Efektivitas Pendekatan Rational Emotive Therapy Dalam Layanan Konseling Kelompok Untuk Mengatasi Gangguan Emosional Siswa
Authors: Aisyah Siti , Tohirin Tohirin 
Published: September 2022

This research aimed at knowing the effectiveness of Rational Emotive Therapy approach on group counseling service in overcoming student emotional disturbance. Quantitative pre-experimental research method was used in this research with pretest posttest one group design. The subjects of this research were the students experiencing high emotional disturbance, and the object was Rational Emotive Therapy approach on group counseling service in overcoming student emotional disturbance. Questionnaire, observation, and documentation were the techniques of collecting the data. Pearson product moment was used to test the questionnaire validity and Alpha Cronbach was for testing the reliability. The data were analyzed by using Wilcoxon test to know whether Rational Emotive Therapy approach on group counseling service in overcoming student emotional disturbance could be implemented. The research findings showed the mean score of student emotional disturbance before the treatment (pretest) was 112.9, and the mean score after the treatment (posttest) was 76.5. Based on the hypothesis test using Wilcoxon test, it was obtained that the probability score of Asymp. Sig. (2-tailed) 0.005 was lower than 0.05, it meant that Null hypothesis (H0) was rejected and Alternative hypothesis (Ha) was accepted. It could be concluded that Rational Emotive Therapy approach on group counseling service could be implemented to decrease student emotional disturbance.
Efektifitas Layanan Konseling Kelompok Dengan Pendekatan Behevioral Teknik Relaksasi Untuk Mengatasi Kejenuhan Belajar Siswa
Authors: Hartono Rudi , Subhan Mhd 
Published: September 2022

This research aimed at knowing how effective group counseling service with behavioral approach to relaxation technique in overcoming student learning saturation. Pre-experimental research method was used in this research with Pretest Posttest One Group design. The subjects were the students experiencing highlearning saturation, and the object was group counseling service with behavioral approach to relaxation technique in overcoming student learning saturation. Questionnaire, observation, and documentation were the techniques of collecting the data. Pearson product moment was used for questionnaire validity test and Alpha Cronbach was used for reliability test. The data analysis that was Wilcoxon test was used to know whether group counseling service with behavioral approach to relaxation technique could be implemented in overcoming student learning saturation. The research findings showed the mean score of student learning saturation before being given treatment group counseling service with behavioral approach to relaxation technique 68.4, and the mean score was 48.4. It could that relaxation technique could be implemented in overcoming student learning saturation.
Pengaruh Komunikasi Efektif terhadap Loyalitas Guru di Sekolah Menengah Kejuruan Negeri Pertanian Terpadu Provinsi Riau
Authors: Thohiroh Siti , Syafaruddin Syafaruddin 
Published: September 2022

This research aimed at knowing the level of effective communication, teacher loyalty, and the influence of effective communication toward teacher loyalty at State Agriculture Integrated Vocational High School Riau Province. The data that were collected by questioner to 75 persons of samples were analyzed by using simple linear regression analysis technique, it was done by using SPSS 21.0 for Windows application program. Based on the analysis, it could be known that the correlation score (rxy) was 0.607 and Fhit (Fchange) was 42.489 with the significant level (p-value) 0.000 that was lower than 0.05. It was compared to rtable 0.227 at 5% significant level (n=75), so Ha was accepted and H0 was rejected. It showed that effective communication variable (X) influenced teacher loyalty variable (Y) significantly. The coefficient of determination (R square) based on the regression test result was 0.368, and it meant that 36.8% of teacher loyalty variable could be influenced by effective communication variable, and the rest 63.2% was influenced by other variables such as: compensation, working satisfaction, working participation, the health implementation, motivation, and others. Therefore, it could be stated that increasing teacher loyalty at State Agriculture Integrated Vocational High School Riau Province could be done by increasing the level of effective communication at the school.
Meningkatkan Kompetensi Guru Dalam Mengelola Administrasi Pembelajaran Melalui Supervisi Klinis di MA Maarif Kota Pekanbaru
Authors: Putri Elza 
Published: September 2022

Penelitian ini dilakukan dua siklus, masing-masing siklus terdiri dari tahapan perencanaan, pelaksanaan, observasi dan refleksi yang meliputi supervisi akademik secara klinis dengan melakukan wawancara langsung. pada Siklus I guru yang berkategori baik dalam mengelola administrasi pembelajaran adalah 28 % dan yang berkategori kuang adalah 72% . Berarti lebih dari masih banyak guru yang belum memahami tentang administrasi pembelajaran yang sangat dibutuhkan dalam proses belajar mengajar dan kemajuan siswa dalam pembelajaran dan (2) sedangkan pada hasil penelitian Siklus II guru yang berkategori baik dalam mengelola administrasi pembelajaran mengalami peningkatan yang signifikan yaitu 78 % dan yang berkategori kurang adalah 22%. Sehingga dari hasil penelitian Siklus I dan Siklus II, penelitian ini sudah berhasil, karena sudah mencapai 78% indikator keberhasilannya, sehingga dapat disimpulkan bahwa dengan pembinaan dengan supervisi klinis secara berkelanjutan yang dilakukan pengawas madrasah dapat meningkatkan kompetensi guru dalam mengelola administrasi pembelajaran di MA Maarif Kota Pekanbaru.