bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of geraniol and vitamin C on diethylnitrosamine induced experimental hepatocellular carcinogenesis
Authors: TAŞKIN ŞENOL Gamze , KAPLAN Halil Mahir , BOYAN Neslihan , OĞUZ Özkan , ŞİNGİRİK Ergin 
Published: June 2022

Purpose: This study aimed to investigate the protective effect of geraniol and vitamin C on the experimental hepatocellular carcinogenesis (HCC) model by inducing FL83B hepatocyte cell lines with diethylnitrosamine (DENA).
Materials and Methods: The cells prepared in the medium were incubated with DENA (5 μM), geraniol (5 μM), and vitamin C (50 μM) for 48 hours in an incubator at 37 °C and 5% CO2. Groups were designed as follows: Group 1 (Control), group 2 (DENA Control), group 3 (DENA+Geraniol), group 4 (DENA+Vitamin C), and group 5 (DENA+Geraniol+Vitamin C) on standard cell culture plates. Six plates from each experimental group were studied. After the homogenization was centrifuged, analyses of pathway mediators NF-ĸB, AIF, caspase-3, BCL-2, bax, gadd153, GRP78, and COX were performed by the Elisa method.
Results: The expression of Bax, caspase-3, COX-2, NFkB, GADD153, AIF, and GRP78 increased in cancer cells when compared to group 1 and decreased in other groups where antiproliferative agents were applied. Bcl-2 expression is decreased when compared to group 1, and expression is increased in other groups where antiproliferative agents are applied.
Conclusion: There was a significant hepatoprotective effect in the groups administered geraniol+vitamin C on pathway mediators in a DENA-induced HCC model.
Impact of Ergodic versus Nonergodic Seismic Hazard Estimation on the Risk Assessment of Liquefaction-Induced Ground Damage
Authors: Liu Chenying , Macedo Jorge 
Published: June 2022

ABSTRACT
The seismic risk assessment of liquefaction-induced ground damage requires the hazard estimation of ground-motion intensity measures (IMs) through probabilistic seismic hazard analyses (PSHA). Current practice implements PSHA using ground-motion models (GMMs) developed under the ergodic assumption, which considers that the distribution of ground-motion IMs over time at a single site is the same as the distribution of ground-motion IMs over space. With the rapid growth of ground-motion databases, recent efforts have shown that ground-motion recordings are affected by location-specific systematic and repeatable effects favoring the transition to nonergodic approaches. However, the impact of using ergodic versus nonergodic PSHA (accounting for source, path, and site repeatable effects) on the risk assessment of liquefaction-induced damage has not been explored, which is the objective of this study. We consider three sites in California with different availability of ground-motion data to investigate the effects of the amount of available information on constraining repeatable effects and how this affects the final risk estimates within a nonergodic approach. In this context, the nonergodic-based estimates are compared against their ergodic counterparts, and insights are shared. The results from site-specific and regional assessments show important differences between ergodic and nonergodic estimates in terms of the mean risk and its uncertainty; the differences are dependent on the amount of data, and highlight the value of information (i.e., data) in nonergodic approaches.
The effect of drip irrigation on the formation of the root system of raspberry seedlings in the conditions of the Non-black soil zone of Russia
Authors: Dubenok N. N. , Ilchenko K. Yu. , Gemonov A. V. 
Published: June 2022

Relevance. Currently, there is an acute problem of meeting the growing demand for berry and fruit products. One of the ways to intensify agricultural production in the field of horticulture and crop production is to increase the efficiency of environmental management through the use of resource-saving technologies. One of these technologies is drip irrigation, which improves the quality of crop production.Materials and methods. Field studies were carried out on the territory of the educational and experimental farm of the laboratory "Michurinsky Garden" of the Russian State Agrarian University – Moscow Timiryazev Agricultural Academy. The experiment was established in the fall of 2018 and is a two-factor study of various levels of moisture on the growth and development of raspberry seedlings. The first factor included options for maintaining soil moisture in the range: 1) control (without irrigation); 2) not less than 60% of the lowest moisture capacity; 3) not less than 70% of the lowest moisture capacity; 4) not less than 80% of the lowest moisture capacity. The second factor was the raspberry varieties Solnyshko and Nagrada.Results. Constructed moisture contours according to the study options showed that drip irrigation contributes to the optimum moisture concentration in the soil for seedlings. The most developed root system in comparison with the control was obtained on irrigated variants with maintaining a moisture content of at least 70 and 80% of the lowest moisture capacity. Here, the maximum values of the volume of the root system, the number of roots, and the average length of the root were obtained. It was revealed that in variants with irrigation, the root system of seedlings spreads in the upper layer (mainly 5-15 cm).
Phenolic compounds of cultivated chicory (<i>Cichorium intybus</i> L.)
Authors: Mavrina P. O. , Malankina E. L. 
Published: June 2022

Common chicory (Cichorium intybus L.) is widely known in traditional medicine of many countries, but in official medicine its use is limited as a part of biologically active additives. Despite the available information about pharmacological activity of leaf extracts, their use as a medicinal herbal raw material is almost not considered. The purpose of the work is to study the accumulation dynamics of phenolic compounds (PC) in the leaves of cultivated chicory to optimize the time of harvesting the above-ground mass. The article presents data on the accumulation dynamics of PC in the leaves of two varieties of cultivated chicory, and also compares the obtained data with similars of wild-growing chicory.Results. It was noted that the content of phenolic compounds in the leaves of cultivated chicory is 1,5-2 times higher in comparison with the raw materials of wild plants. The studied varieties differ in the content of PC by 8% in average. It has been established that the main phenolic compounds in the leaves of cultivated chicory are chicoric, chlorogenic and cafftaric acids; their total content in the obtained extracts is 55 %. It was noted that the period of maximum accumulation of PC in leaves falls on the end of september – beginning of october. The established chemical composition, a higher content of phenolic compounds compared to wild plants, as well as the coincidence of the maximum accumulation of PC in the leaves with the approximate date of harvesting chicory roots allows us to consider its cultivation in culture as a promising direction with the aim of the integrated use of the obtained raw materials for both food and pharmaceutical industry.
Photometric method of response to changes in potato varieties to nitrogen stress
Authors: Volkova E. N. , Sheloukhova N. A. 
Published: June 2022

Relevance. The use of non-invasive photometric methods for assessing the stress states of plants makes it possible to assess the physiological state and resistance of plants.Material and methods. In small-field and vegetation experiments, we studied the photometric indicators of the physiological response of potato varieties (reflection coefficients in different ranges) to nitrogen stress created by five doses of fertilizers using contact (N-tester) and remote (N-sensor) methods.Results. Potato varieties released for the conditions of the North-Western region of the Russian Federation were studied for their ability to withstand stress provided by low and high levels of nitrogen nutrition of plants and different weights of planting tubers. The resistance of plants of different genotypes to external and internal stressors was studied by the reflection coefficients measured in 4 channels, which characterized the differences in the physiological state of plants. Ensuring the potential genotypic resistance of the organism in the form of a decrease in FIS F1,3 corresponds to the inclusion of various mechanisms of plant adaptation to external or internal influences, depending on the genotype. In the vegetative experiment, of the studied photo-optical reflection coefficients, the most informative were the FIS F1,3 indicators, which showed that the overall viability of such varieties as Peterburgsky, Charodey and Kholmogorsky turned out to be increased. The reaction type of the Kholmogorsky variety is the most promising for growing plants under stress conditions.
Pengaruh Metode Bermain Peran terhadap Hasil Belajar PKN di SD Donorojo
Authors: Irawati Devi , Mukodi Mukodi , Suryatin Suryatin 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui adakah pengaruh metode bermain peran terhadap hasil belajar di SD kecamatan Donorojo pada mata pelajaran PKn materi bangga sebagai bangsa Indonesia. Jenis penelitian ini adalah Quasi Eksperimen. Penelitian ini dilakukan pada semester genap tahun pelajaran 2018. Subjek penelitian ini adalah SD yang dipilih secara random sampling. Pemgumpulan data menggunakan dokumentasi dan tes hasil belajar. Teknik analisis menggunakan bantuan Program SPSS for Windows 16. Hasil penelitian menunjukkan bahwa ada pengaruh signifikan pada hasil belajar siswa kelas eksperimen yang mendapatkan perlakuan khusus dengan metode bermain peran dibandingkan dengan kelas yang diberi perlakuan pembelajaran biasa menggunakan ceramah. Berdasarkan hasil rerata diperoleh kelas eksperimen memiliki rata-rata 88,33 yang berarti hasil rerata tersebut lebih tinggi daripada kelas kontrol dengan rata-rata 83,00. Berdasarkan hasil uji-t pada kelas kontrol dan kelas eksperimen diperoleh nilai t sig0.023, nilai sig<0,05 (0.023<0,05). Hal ini menunjukkan bahwa ada pengaruh metode bermain peran terhadap hasil belajar PKn di SDN Kecamatan Donorojo tahun pelajaran 2018.
Preparing of Active Recombinant AEP free of Acid-activation.
Authors: Ma Muge , Tang Simon TM , Luk Louis YP 
Published: June 2022

Abstract
Asparaginyl endopeptidase is a useful biocatalyst for site-specific protein bioconjugation. However, existing recombinant protocol is lengthy requiring cap removal of the zymogenic enzymes through acid activation and extra chromatographic steps. Here, we describe an activation-free approach for AEP preparation where the cap and core domains are prepared as separate entities during gene expression. An AEP variant from Oldenlandia affinis (OaAEP1b-C247A) can be prepared without the need of acid treatment giving a yield of ~1.5-2.2 mg of enzyme per litre of culture. Likely because of a decrease in chromatography time and an increase of homogeneity, activity of the split AEP was found to be ~3-fold higher than those obtained using existing protocols, highlighting its potential usefulness.
Left axillary cannulation for acute type A aortic dissection
Authors: Sun Yangxue , Meng MaoLong , Li Gang , Guo HongWei 
Published: June 2022

Abstract
The most commonly used arterial cannulation sites for type A aortic dissection are right axillary artery, femoral artery and both. Direct central aortic cannulation has also been reported. In rare cases, it is extremely difficult to choose an arterial cannulation site for type A aortic dissection due to involvement of the right axillary and both femoral arteries. Herein, we present a 39-year-old male with acute type A aortic dissection with involvement of the right axillary and both femoral arteries. Left axillary cannulation was made and selective cerebral perfusion was performed through direct left common carotid artery cannulation during circulatory arrest. Surgery was performed to replace the ascending aorta and total arch combined with a frozen elephant trunk implantation. The patient recovered uneventfully. To our knowledge, this is a rare case of total aortic arch replacement with frozen elephant trunk implantation through left axillary arterial cannulation for type A aortic dissection in the literature. Left axillary cannulation is a safe and useful choice for type A aortic dissection surgery when right axillary and femoral cannulation are not safe and reliable.
Stents versus Bypass Surgery – 3-Year Mortality Risk of Patients with Coronary Interventions Aged 50+ in Germany
Authors: Nestler Sophia , Kreft Daniel , Donndorf Peter , Ince Hüseyin , Doblhammer Gabriele 
Published: June 2022

Abstract
ObjectivesDue to demographic aging, the prevalence of coronary artery disease (CAD) is expected to increase in the future, resulting in a growing demand for stent and bypass interventions. This study aims to investigate the mortality risk of patients following conventional coronary artery bypass grafting (CABG) or endovascular procedure by the implantation of bare-metal stents (BMS) or drug-eluting stents (DES).MethodsBased on a random sample of 250,000 members of Germany’s largest health insurance ‘Allgemeine Ortskrankenkassen’ (AOK) from 2004 to 2015, incident CAD patients were analyzed by Cox Proportional-Hazard models. Risk adjustment was made for sex, age, other cardiac diseases, non-cardiovascular comorbidities and years since intervention. Due to later admission of DES and thus a shorter observation time, mortality was examined for 3 years since the intervention. ResultsBMS represented the most frequent procedure (48%). We found similar proportions of CABG (19%) and DES interventions (23%). After risk adjustment, the models showed a 21% (p=0.004) lower mortality risk of patients with DES and also a 21% (p=0.002) lower mortality risk of CABG patients compared to persons with BMS.ConclusionBased on a large-scale dataset, our study demonstrated survival advantages of CABG and DES interventions over BMS, with no differences between the DES and CABG groups. The results help to assess the risks of coronary interventions. Aspects of quality of life, severity of postoperative physical limitations, duration of rehabilitation, patients’ preferences, and aspects of cost-effectiveness for hospitals and society should be further considered.
A comparative LCA of external wall assemblies in context of Iranian market: considering embodied and operational energy through BIM application
Authors: Jafari Milad , Khoshand Afshin , Sadeghi Naimeh , Mirzanagh Pantea Abdollahi 
Published: June 2022

Abstract
Building envelopes have a critical role in the construction sector's sustainability. The main aim of this research is to assess the environmental impacts of typical exterior wall assemblies and present the best option to the Iranian market, taking into account both embodied and operational energy. Autodesk Green Building studio is used to determine the operating loads of each wall. Simapro, a life cycle assessment software, is used to help manage data on environmental impacts. The results show that the most severe damage category for all of the analyzed walls is human health. Also, the environmental impact of the end-of-life stage is insignificant in comparison with the production and use stages. If reducing carbon emissions is a major priority, replacing one square meter of masonry brick wall (the worst option) with Prefabricated extruded polystyrene (XPS) drywall (the best option) could save 1257.85 kgCO2eq. The operational phase of the specified walls has a wide range of environmental impacts. Prefabricated Knauf drywall and prefabricated XPS drywall consume less energy for the operating phase since they use a sufficient quantity of isolations, leading to better total environmental performance. In conclusion, the thermal performance of building materials should be given more attention.
Prevalence of Systemic Lupus Erythematosus and coexisting autoimmune diseases in Puerto Rico in the context of Hurricane Maria and the COVID-19 pandemic
Authors: Gilman Casey K. , Rivera Evián Pérez , Rincones Alexandra , Chervony Melyorise Sepúlveda , Lee Johanna , Marquez Alan , Castilla Christian , Santiago Michelle , Cortes Ada 
Published: June 2022

Abstract
Background: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that tends to coexist with other autoimmune conditions. The prevalence and etiology of the concurrent autoimmune diseases of SLE patients remains unknown. In Puerto Rico (PR) the prevalence of SLE was last reported in 2007 as a striking 159 per 100,000 individuals. The purpose of this investigation is to provide an updated prevalence of SLE and its autoimmune comorbidities in Puerto Rico in the setting of Hurricane Maria and the COVID-19 pandemic. Methods: Patient record information from the Puerto Rico Health Insurance Administration (PRHIA) was used to identify individuals with SLE between the years 2018 through 2020. Demographic characteristics such as age and sex were recorded. In addition, medications and comorbidities were evaluated. Prevalence was estimated.Results: A total of 12,918 cases of SLE were analyzed. Prevalence was estimated to be 536 per 100,000 individuals at its peak in 2019. In individuals with SLE, 3.6% had at least 1 additional autoimmune diagnosis. Patients who were female, aged 35 to 54, or with a record of using corticosteroids within the past three years were identified as more likely to be affected by an additional autoimmune disease.Conclusions: Our findings reveal an increased prevalence of SLE as compared to previous studies in both the United States and Puerto Rico. We also contributed to limited literature on the co-occurence of SLE with other autoimmune diseases and its associated factors.
Treatment of Extramedullary Plasmacytoma of the Rectum with Endoscopic Mucosal Resection: A Case Report and Literature Review
Authors: Fan Ling , Fu Yan , Liu Yi , Huang Hua 
Published: June 2022

Abstract
Background Extramedullary plasmacytoma (EMP) is an unusual plasma cell disease.We report a case of EMP arising in the rectum, which is fully removed using endoscopic mucosal resection (EMR).Methods The patient’s clinical, endoscopic, and histologic data were reviewed, as well as the past literature of rectal EMP with a focus on the clinical presentation, treatment and outcome.Results A 64-year-old woman was referred to our hospital with recurrent diarrhea for longer than half a month. She underwent colonoscopy which revealed a polypoid lesion. The lesion was fully excised using EMR, and histopathological examination coupled with immunohistochemistry of the endoscopic biopsy confirmed a primary EMP of the rectum. She did not receive radiotherapy or chemotherapy after being diagnosed with EMP and experienced no recurrence or progression during the 6-month follow-up period.Conclusions Rectal EMP is an extremely rare clinical entity, Only 14 cases have been reported in the English-language literature as far as we know. Clinical suspicion is infrequent owing to its location and nonspecific manifestations. The diagnosis of EMP requires biopsy-proven monoclonal plasma cell infiltration of a single lesion, and the exclusion of multiple myeloma. Although EMP is a highly radiosensitive tumor, endoscopic therapy is increasingly becoming a good option for colorectal EMP when complete endoscopic resection of the tumor is possible. Although rectal EMP has an indolent course and favorable prognosis, long-term follow-up is recommended due to the possibility of relapse or progression to multiple myeloma.
Water, water everywhere and not a streamflow gauge in sight: Estimating freshwater inflows in an ungauged watershed at the Big Boggy National Wildlife Refuge, USA
Authors: Madewell Matthew J. , Feagin Rusty A. , Huff Thomas P. , Balboa Bill 
Published: June 2022

Abstract
Bays and estuaries often rely on freshwater inflows to maintain the salinity balance necessary to sustain their fisheries. Reduced freshwater inflows, particularly during summer seasons, can be detrimental to the health of these systems. Despite an extensive network of streamflow gauges in the U.S., many coastal watersheds remain ungauged. Our objective was to identify a way to quickly build a water budget for an ungauged watershed, using limited data, to determine its freshwater inflow contributions to an estuary. We developed and tested this method for Big Boggy Creek, which flows into East Matagorda Bay (EMB), Texas. Streamflow into and out of Big Boggy Creek was quantified at key upstream and downstream points. Over the study period, we found average monthly freshwater inflows of 1,897 megaliters (ML). Historic and predicted freshwater inflows over a longer time period were calculated using a data-driven model, based on our water budget. Historic monthly inflows for this model averaged 2,000 ML from 1953 to 2019 for Big Boggy Creek. Predicted inflows followed three climate scenarios outlined by the Intergovernmental Panel on Climate Change. Using these findings, we developed an inflow decision tool to assist resource managers in assessing future freshwater inflows into EMB. We show two inflow improvement actions for EMB that can be informed by using this tool—purchasing water from the local river authority and increasing the effective watershed. The approaches developed in this study can be applied to similarly ungauged watersheds to budget, model, and predict their freshwater inflow contributions to estuaries.
Privacy-preserving, Efficient, and Effective Machine Learning
Authors: Wu Chuhan , Wu Fangzhao , Qi Tao , Huang Yongfeng , Xie Xing 
Published: June 2022

Abstract
Privacy protection is critical for responsible artificial intelligence. Federated learning is a privacy-aware machine learning paradigm, which is often combined with differential privacy to guarantee privacy protection. Unfortunately, existing methods cannot achieve a satisfactory tradeoff between privacy and utility when the models are large, and their computation and communication costs are also huge. Here, we present a differentially private, efficient, and effective machine learning method named FedPrompt to learn big models in a federated way via prompt tuning. It only learns, perturbs, and exchanges the small prompt models injected into the big models. FedPrompt is validated on five datasets. The results show FedPrompt can achieve 0.5%~34.7% better performance than standard federated learning under same privacy budgets, meanwhile saving 99% of communication cost, 75% of memory, and 64% of training time. FedPrompt offers a new direction to efficiently and effectively distributed machine learning with privacy guarantees.