bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Survey Methods to Effectively Sample Juvenile Red Snapper along the Atlantic Coast of Florida
Authors: Brodie Russell B. , Solomon Justin J. , Paperno Richard , Switzer Theodore S. , Swanson Christopher E. 
Published: August 2022

AbstractUnderstanding of the early life history of Red Snapper Lutjanus campechanus throughout the U.S. Atlantic Ocean (hereafter, “Atlantic”) is limited, in part, due to the paucity of juveniles (<150 mm TL) collected in long‐term fishery‐independent surveys in the region. This is in sharp contrast to the Gulf of Mexico (hereafter, “Gulf”), where juvenile Red Snapper have been consistently collected in surveys. This apparent regional disparity is poorly understood. Red Snapper nursery habitats may differ between the Atlantic and the Gulf, previous Atlantic surveys may not have included important nursery habitat, or sampling gear used in the Atlantic may not be effective at collecting juveniles. A 2‐year fishery‐independent study was conducted along the Atlantic coast of Florida to test whether juvenile Red Snapper could be effectively sampled with two types of gear not commonly used there: a semi‐balloon trawl like those used in long‐term groundfish surveys in the Gulf and small‐mesh Z‐traps. In total, 194 Red Snapper were collected in the trawl samples and 202 Red Snapper were collected in the Z‐trap samples—mostly juveniles (age 0 and age 1) captured in nearshore waters (<30 m deep). Like the Gulf, shallow coastal waters in the Atlantic likely function as nursery habitat for Red Snapper. Primarily small age‐0 Red Snapper were collected during trawl sampling, which targeted unconsolidated nonreef habitats, whereas larger age‐0 and age‐1 and older Red Snapper were collected during trap sampling, which targeted hard‐bottom reef habitats. Although this study represents the most successful sampling of juvenile Red Snapper in the Atlantic to date, further research is required to delineate the northern and southern extents of Red Snapper nursery grounds. Nevertheless, our results provide a framework for developing a fishery‐independent survey that targets juvenile Red Snapper in the Atlantic to provide valuable data for quantifying recruitment and monitoring the status and recovery of this economically important species.
Holomorphic Family of Dirac–Coulomb Hamiltonians in Arbitrary Dimension
Authors: Dereziński Jan , Ruba Błażej 
Published: August 2022

AbstractWe study massless one-dimensional Dirac–Coulomb Hamiltonians, that is, operators on the half-line of the form $$D_{\omega ,\lambda }:=\begin{bmatrix} -\frac{\lambda +\omega }{x} &{} - \partial _x \\ \partial _x &{} -\frac{\lambda -\omega }{x} \end{bmatrix}$$

D

ω
,
λ

:
=

-

λ
+
ω

x

-

∂
x

∂
x

-

λ
-
ω

x

. We describe their closed realizations in the sense of the Hilbert space $$L^2(\mathbb {R}_+,\mathbb {C}^2)$$

L
2

(

R
+

,

C

2

)

, allowing for complex values of the parameters $$\lambda ,\omega $$

λ
,
ω

. In physical situations, $$\lambda $$
λ
is proportional to the electric charge and $$\omega $$
ω
is related to the angular momentum. We focus on realizations of $$D_{\omega ,\lambda }$$

D

ω
,
λ

homogeneous of degree $$-1$$

-
1

. They can be organized in a single holomorphic family of closed operators parametrized by a certain two-dimensional complex manifold. We describe the spectrum and the numerical range of these realizations. We give an explicit formula for the integral kernel of their resolvent in terms of Whittaker functions. We also describe their stationary scattering theory, providing formulas for a natural pair of diagonalizing operators and for the scattering operator. We describe the point spectrum of their nonhomogeneous realizations. It is well-known that $$D_{\omega ,\lambda }$$

D

ω
,
λ

arise after separation of variables of the Dirac–Coulomb operator in dimension 3. We give a simple argument why this is still true in any dimension. Furthermore, we explain the relationship of spherically symmetric Dirac operators with the Dirac operator on the sphere and its eigenproblem. Our work is mainly motivated by a large literature devoted to distinguished self-adjoint realizations of Dirac–Coulomb Hamiltonians. We show that these realizations arise naturally if the holomorphy is taken as the guiding principle. Furthermore, they are infrared attractive fixed points of the scaling action. Beside applications in relativistic quantum mechanics, Dirac–Coulomb Hamiltonians are argued to provide a natural setting for the study of Whittaker (or, equivalently, confluent hypergeometric) functions.
The Exceptional Tits Quadrangles Revisited
Authors: Mühlherr Bernhard , Weiss Richard M. 
Published: August 2022

AbstractTits polygons are generalizations of Moufang polygons in which the neighborhood of each vertex is endowed with an “opposition relation.” There is a standard construction that produces a Tits polygon from an arbitrary irreducible spherical building of rank at least 3 when paired with a suitable Tits index. In this note, we complete the proof of a characterization of the Tits quadrangles that arise in this way from the spherical building associated to an exceptional algebraic group.
A pilot study to evaluate changes in pelvic floor muscle tone following pelvic organ prolapse surgery using a novel intra-vaginal pressure sensor device
Authors: McConnell James , Murtagh Lynsey , Lim Molly , Pedofsky Laura , Kruger Jennifer , Budgett David , Jha Swati 
Published: August 2022

Abstract
Introduction and hypothesis
Pelvic floor muscle weakness is a common cause of pelvic organ prolapse and urinary incontinence. Surgical repair of prolapse is commonly undertaken; however, the impact on pelvic floor muscle tone is unknown. The aim of this study was to compare the effect of anterior and posterior colporrhaphy on pelvic floor activation.

Methods
Patients aged under 70 undergoing primary anterior or posterior colporrhaphy were recruited. Intra-vaginal pressure was measured at rest and during pelvic floor contraction using the Femfit® device (an intra-vaginal pressure sensor device [IVPSD]). Peak pressure and mean pressure over 3 s were measured in millimetres of mercury. The pre- and post-operative measurements were compared. The difference between the means was assessed using Cohen’s D test, with significance set at p<0.05

Results
A total of 37 patients completed pre- and post-operative analysis, 25 in the anterior colporrhaphy group and 12 in the posterior colporrhaphy group. Anterior colporrhaphy showed no significant change in pelvic floor tone. Change in peak pressure was −1.71mmHg (−5.75 to 2.33; p=0.16) and change in mean pressure was −0.86 mmHg (−4.38 to 2.66; p=0.31). Posterior colporrhaphy showed a significant increase in peak pelvic floor muscle tone of 7.2 mmHg (0.82 to 13.58; p=0.005) and mean pressure of 4.19 mmHg (−0.09 to 8.47; p=0.016).

Conclusions
Posterior colporrhaphy significantly improves pelvic floor muscle tone, whereas anterior colporrhaphy does not. Improved understanding of the impact of pelvic floor surgery may guide future management options for other pelvic floor disorders. Further work is needed to confirm the association of this improvement in pelvic floor disorders.
The Watts Connectedness Scale: a new scale for measuring a sense of connectedness to self, others, and world
Authors: Watts Rosalind , Kettner Hannes , Geerts Dana , Gandy Sam , Kartner Laura , Mertens Lea , Timmermann Christopher , Nour Matthew M. , Kaelen Mendel , Nutt David , Carhart-Harris Robin , Roseman Leor 
Published: August 2022

AbstractRationaleA general feeling of disconnection has been associated with mental and emotional suffering. Improvements to a sense of connectedness to self, others and the wider world have been reported by participants in clinical trials of psychedelic therapy. Such accounts have led us to a definition of the psychological construct of ‘connectedness’ as ‘a state of feeling connected to self, others and the wider world’. Existing tools for measuring connectedness have focused on particular aspects of connectedness, such as ‘social connectedness’ or ‘nature connectedness’, which we hypothesise to be different expressions of a common factor of connectedness. Here, we sought to develop a new scale to measure connectedness as a construct with these multiple domains. We hypothesised that (1) our scale would measure three separable subscale factors pertaining to a felt connection to ‘self’, ‘others’ and ‘world’ and (2) improvements in total and subscale WCS scores would correlate with improved mental health outcomes post psychedelic use.ObjectivesTo validate and test the ‘Watts Connectedness Scale’ (WCS).MethodsPsychometric validation of the WCS was carried out using data from three independent studies. Firstly, we pooled data from two prospective observational online survey studies. The WCS was completed before and after a planned psychedelic experience. The total sample of completers from the online surveys wasN = 1226. Exploratory and confirmatory factor analysis were performed, and construct and criterion validity were tested. A third dataset was derived from a double-blind randomised controlled trial (RCT) comparing psilocybin-assisted therapy (n = 27) with 6 weeks of daily escitalopram (n = 25) for major depressive disorder (MDD), where the WCS was completed at baseline and at a 6-week primary endpoint.ResultsAs hypothesised, factor analysis of all WCS items revealed three main factors with good internal consistency. WCS showed good construct validity. Significant post-psychedelic increases were observed for total connectedness scores (η2 = 0.339,p < 0.0001), as well as on each of its subscales (p < 0.0001). Acute measures of ‘mystical experience’, ‘emotional breakthrough’, and ‘communitas’ correlated positively with post-psychedelic changes in connectedness (r = 0.42,r = 0.38,r = 0.42, respectively,p < 0.0001). In the RCT, psilocybin therapy was associated with greater increases in WCS scores compared with the escitalopram arm (ηp2 = 0.133, p = 0.009).ConclusionsThe WCS is a new 3-dimensional index of felt connectedness that may sensitively measure therapeutically relevant psychological changes post-psychedelic use. We believe that the operational definition of connectedness captured by the WCS may have broad relevance in mental health research.
Genetics and epigenetics: paternal adolescent ethanol consumption in serotonin transporter knock-out rats and offspring sensitivity to ethanol
Authors: Hussain Sahir , Lesscher Heidi M. D. , Day Darren J. , Ellenbroek Bart A. 
Published: August 2022

Abstract
Rationale
Alcohol use disorder (AUD) is shown to have an overall heritability of around 50%. One of the genes associated with AUD is SLC6A4 (solute carrier family 6 member A4) which codes for the serotonin transporter (SERT). The study looked at serotonin dysfunction on ethanol consumption in adolescents and the subsequent intergenerational effects of drinking by using a rat model: SERT+/+ (regular functioning), SERT+/− (50% transporter reduction) and SERT−/− (complete reduction).

Objectives
We investigated sex and genotype differences in ethanol consumption in SERT knock-out Wistar rats (F0) followed by studying behaviour in the offspring (F1) of the male drinkers to assess effects of paternal alcohol consumption.

Methods
An intermittent access two-bottle choice paradigm (IA2BC) was used to yield ethanol drinking behaviour in F0 adolescent Wistar rats. The highest drinking males were mated to alcohol-naive females and their offspring were compared with controls. Drinking behaviour (IA2BC) and ethanol-induced motor coordination effects (via rotarod) were measured in the F1s.

Results
F0 drinking saw no SERT genotype differences in males. However, females consumed higher volumes of ethanol compared to males, with SERT−/− females showing the highest intake. A clearer genotype effect was seen in the F1 animals, with reduction in SERT activity leading to enhanced ethanol intake in both sexes. Importantly, paternal exposure to ethanol significantly reduced the ethanol induced motor side effects in offspring, independent of sex and genotype.

Conclusions
These indicate a difference in the way genetic factors may act across sexes and suggest the involvement of epigenetic mechanisms in the intergenerational effects of alcohol.
SIRT in 2025
Authors: Ponziani Francesca Romana , Santopaolo Francesco , Posa Alessandro , Pompili Maurizio , Tanzilli Alessandro , Maestri Marta , Pallozzi Maria , Ibba Francesca , Manfredi Riccardo , Gasbarrini Antonio , Iezzi Roberto 
Published: August 2022

AbstractSelective internal radiation therapy represents an endovascular treatment option for patients with primary liver malignancies, in different clinical stages. Potential applications of this treatment are in early-stage hepatocellular carcinoma, as a curative option, or in combination with systemic treatments in intermediate and advanced-stages. This review, based on existing literature and ongoing trials, will focus on the future of this treatment in patients with hepatocellular carcinoma, in combination with systemic treatments, or with the use of new devices and technological developments; it will also describe new potential future indications and structural and organizational perspectives.
External validation of two mpMRI-risk calculators predicting risk of prostate cancer before biopsy
Authors: Pallauf Maximilian , Steinkohl Fabian , Zimmermann Georg , Horetzky Maximilian , Rajwa Pawel , Pradere Benjamin , Lindner Andrea Katharina , Pichler Renate , Kunit Thomas , Shariat Shahrokh F. , Lusuardi Lukas , Drerup Martin 
Published: August 2022

Abstract
Purpose
Risk calculators (RC) aim to improve prebiopsy risk stratification. Their latest versions now include multiparametric magnetic resonance imaging (mpMRI) findings. For their implementation into clinical practice, critical external validations are needed.

Methods
We retrospectively analyzed the patient data of 554 men who underwent ultrasound-guided targeted and systematic prostate biopsies at 2 centers. We validated the mpMRI-RCs of Radtke et al. (RC-R) and Alberts et al. (RC-A), previously shown to predict prostate cancer (PCa) and clinically significant PCa (csPCa). We assessed these RCs’ prediction accuracy by analyzing the receiver-operating characteristics (ROC) curve and evaluated their clinical utility using Decision Curve Analysis (DCA), including Net-Benefit and Net-Reduction curves.

Results
We found that the Area Under the ROC Curve (AUC) for predicting PCa was 0.681 [confidence interval (CI) 95% 0.635–0.727] for RC-A. The AUCs for predicting csPCa were 0.635 (CI 95% 0.583–0.686) for RC-A and 0.676 (CI 95% 0.627–0.725) for RC-R. For example, at a risk threshold of 12%, RC-A needs to assess 334 and RC-R 500 patients to detect one additional true positive PCa or csPCa patient, respectively. At the same risk threshold of 12%, RC-A only needs to assess 6 and RC-R 16 patients to detect one additional true negative PCa or csPCa patient.

Conclusion
The mpMRI-RCs, RC-R and RC-A, are robust and valuable tools for patient counseling. Although they do not improve PCa and csPCa detection rates by a clinically meaningful margin, they aid in avoiding unnecessary prostate biopsies. Their implementation could reduce overdiagnosis and reduce PCa screening morbidity.
Anatomist Hermann Stieve used Nazi victims for his research on the menstrual cycle, but did he also fabricate facts?
Authors: Winkelmann Andreas , Freiberger Isabel 
Published: August 2022

AbstractPurposeHermann Stieve (1886–1952), director of the Berlin Anatomical Institute from 1935, benefited from the rise of execution numbers during the “Third Reich”. He used organs and tissues from executed women for his histological research on the reproductive organs and investigated the influence of “nervous agitation” on the cyclical changes of endometrium and ovary. It is still controversial how he was able to acquire intimate data on the executed women and it was therefore suggested that some of his data may have been “invented”.MethodsNewly emerged dissection protocols and histological drawings from Stieve’s research, together with archived court records, enable a more detailed analysis of Stieve’s published data.ResultsWe extracted 304 case descriptions from Stieve’s publications. Of these, 88 could be linked with 33 identifiable women and related historical records. Nearly all reported causes of death and/or verdicts of executed women were false. Reported clinical data, particularly the day of the menstrual cycle and uterine bleeding shortly before death, are more difficult to verify. We found non-standardised documentation and possible confusions of cases, which may in part be attributable to war effects.ConclusionStieve actively concealed the fate of the executed women, mostly by inventing imaginary stories. This followed a request by the German and Soviet authorities after 1945 not to publish results from cases of political victims, but only from “dangerous criminals”. Scientifically relevant clinical data were not always reported correctly, but are not necessarily fraudulent as different interpretations of this finding can be suggested.
Improved preoperative risk stratification in endometrial carcinoma patients: external validation of the ENDORISK Bayesian network model in a large population-based case series
Authors: Grube Marcel , Reijnen Casper , Lucas Peter J. F. , Kommoss Frieder , Kommoss Felix K. F. , Brucker Sara Y. , Walter Christina B. , Oberlechner Ernst , Krämer Bernhard , Andress Jürgen , Neis Felix , Staebler Annette , Pijnenborg Johanna M. A. , Kommoss Stefan 
Published: August 2022

AbstractPurposePreoperative risk stratification of newly diagnosed endometrial carcinoma (EC) patients has been hindered by only moderate prediction performance for many years. Recently ENDORISK, a Bayesian network model, showed high predictive performance. It was the aim of this study to validate ENDORISK by applying the model to a population-based case series of EC patients.MethodsENDORISK was applied to a retrospective cohort of women surgically treated for EC from 2003 to 2013. Prediction accuracy for LNM as well as 5-year DSS was investigated. The model’s overall performance was quantified by the Brier score, discriminative performance by area under the curve (AUC).ResultsA complete dataset was evaluable from 247 patients. 78.1% cases were endometrioid histotype. The majority of patients (n = 156;63.2%) had stage IA disease. Overall, positive lymph nodes were found in 20 (8.1%) patients. Using ENDORISK predicted probabilities, most (n = 156;63.2%) patients have been assigned to low or very low risk group with a false-negative rate of 0.6%.AUC for LNM prediction was 0.851 [95% confidence interval (CI) 0.761–0.941] with a Brier score of 0.06. For 5-year DSS the AUC was 0.698 (95% CI 0.595–0.800) as Brier score has been calculated 0.09.ConclusionsWe were able to successfully validate ENDORISK for prediction of LNM and 5-year DSS. Next steps will now have to focus on ENDORISK performance in daily clinical practice. In addition, incorporating TCGA-derived molecular subtypes will be of key importance for future extended use. This study may support further promoting of data-based decision-making tools for personalized treatment of EC.
The prognostic impact of B7-H3 and B7-H4 in head and neck squamous cell carcinoma
Authors: Borgmann Mara , Oetting Agnes , Meyer Felix , Möckelmann Nikolaus , Droste Conrad , von Bargen Clara Marie , Möller-Koop Christina , Witt Melanie , Borgmann Kerstin , Rothkamm Kai , Betz Christian , Münscher Adrian , Clauditz Till Sebastian , Rieckmann Thorsten 
Published: August 2022

Abstract
Purpose
Immune checkpoint inhibition is a therapeutic option in many cancer entities. In head and neck squamous cell carcinoma (HNSCC) targeting of the PD-1/PD-L1 (B7-H1) axis is approved in recurrent/metastatic disease and is being explored in the curative setting. Here, we evaluated two related members of the B7 family, B7-H3 & B7-H4, for their prognostic impact under standard treatment.

Methods
A tissue microarray (TMA) of a single center HNSCC cohort was stained for B7-H3 and B7-H4. Staining intensity and the number of tumor cells stained were assessed, and the expression was scored according to an established algorithm. Staining scores were correlated with clinicopathological parameters and associated with patient survival. mRNA levels of both proteins were associated with patient outcome using the TCGA dataset.

Results
mRNA levels of B7-H3 and B7-H4 were not significantly associated with patient survival. TMA analysis revealed interpretable protein staining in 408 samples. Strong staining was the most frequent category for B7-H3 and no staining for B7-H4. In patients with p16-negative oropharyngeal SCC (OPSCC) and in a pooled cohort consisting of p16-negative OPSCC, laryngeal, hypopharyngeal and oral cavity SCC, strong B7-H3 expression was associated with better overall survival. For the latter cohort, this was in part due to reduced lymph node involvement. B7-H3 expression in p16-positive OPSCC and B7-H4 expression were not associated with outcome.

Conclusion
Despite a possible role in tumor immune escape, B7-H3 was associated with favorable prognosis in HPV-negative HNSCC in our cohort. The underlying mechanisms and a potential impact for B7-H3 targeting remain to be elucidated.
Combinatorics and Algorithms for Quasi-Chain Graphs
Authors: Alecu Bogdan , Atminas Aistis , Lozin Vadim , Malyshev Dmitriy 
Published: August 2022

AbstractThe class of quasi-chain graphs is an extension of the well-studied class of chain graphs. This latter class enjoys many nice and important properties, such as bounded clique-width, implicit representation, well-quasi-ordering by induced subgraphs, etc. The class of quasi-chain graphs is substantially more complex. In particular, this class is not well-quasi-ordered by induced subgraphs, and the clique-width is not bounded in it. In the present paper, we show that the universe of quasi-chain graphs is at least as complex as the universe of permutations by establishing a bijection between the class of all permutations and a subclass of quasi-chain graphs. This implies, in particular, that the induced subgraph isomorphism problem is NP-complete for quasi-chain graphs. On the other hand, we propose a decomposition theorem for quasi-chain graphs that implies an implicit representation for graphs in this class and efficient solutions for some algorithmic problems that are generally intractable.