bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Adding Social Cognitive Remediation Therapy to Neurocognitive Remediation Therapy Improve Outcomes in Young People With a Severe Mental Illness?—The Advantage Trial
Authors: Harris Anthony W. F. , Kightley Michelle , Williams Joanna , Ma Cassandra , Dodds Carlie 
Published: March 2022

IntroductionCognitive impairments are a common and significant issue for young people with a severe mental illness. Young people with schizophrenia, bipolar disorder and major depression all experience significant cognitive problems that impede their ability to return to work or study. These neurocognitive problems are frequently exacerbated by social cognitive deficits that interfere with their ability to integrate into the community and understand the social and emotional nuances about them. This study aimed to assess if the addition of a social cognitive remediation treatment to a neurocognitive remediation therapy improved functional outcome.MethodsFive youth mental health services were trained in both the Neuropsychological Educational Approach to Remediation (NEAR) and the Social Cognition and Interaction Training (SCIT) treatments. Participants were randomised between receiving either NEAR + SCIT or NEAR + treatment as usual (TAU) over a 20-week period, with all participants receiving the NEAR treatment first. Symptoms, neurocognition, social cognition and functioning were examined at baseline, end of treatment and at 3 months follow-up and compared between the two arms of the study. The primary outcome was function.ResultsThirty-nine participants were randomised to treatment (Schizophrenia spectrum = 28, Bipolar disorder = 7, Major Depression = 2). The trial was curtailed by Covid-related service restrictions. There was an overall significant improvement in function over time with a trend towards a greater improvement in the NEAR + SCIT arm. No changes in symptoms, neurocognitive or social cognitive measures were seen. While 74% completed treatment only 49% agreed to follow up at 3 months affecting our ability to interpret the findings. Attrition did not differ by arm.ConclusionsIn a pragmatic, service-based research project, treatment aimed at improving cognition enhanced functional outcome in young people with a range of severe mental illnesses. There was a trend towards improved function in young people who had a combined NEAR + SCIT approach.Clinical Trial RegistrationIdentifier: ACTRN12622000192785.
Clinical Guidelines of the Egyptian Psychiatric Association for the Management of Treatment-Resistant Unipolar Depression in Egypt
Authors: Abdel-Wahab Momtaz , Okasha Tarek , Shaheen Mostafa , Nasr Mohamed , Molokheya Tarek , Omar Abd ElNasser , Rabie Menan A. , Samy Victor , Hamed Hany , Ali Mohamed 
Published: March 2022

BackgroundMajor depressive disorder (MDD) is a public health burden that creates a strain not only on individuals, but also on the economy. Treatment-resistant depression in the course of major depressive disorder represents a clinically challenging condition that is defined as insufficient response to two or more antidepressant trails with antidepressants of the same or different classes that were administered at adequate daily doses for at least 4 weeks.Objective/HypothesisTo develop a treatment guideline for Treatment Resistant Depression (TRD).MethodologyExperts in the field gathered and reviewed the available evidence about the subject. Then, a series of meetings were held to create recommendations that can be utilized by Egyptian psychiatrists.ResultsThe guidelines provide recommendations in various clinical settings. It evaluates different situations, such as patients at risk of resistance, those with resistance and recommends strategies to resolve the clinical case.ConclusionThe consensus guidelines will improve the outcomes of patients, as they provide recommendations across various domains that are of concern for the practicing psychiatrist.
Process Evaluation of an Application-Based Salt Reduction Intervention in School Children and Their Families (AppSalt) in China: A Mixed-Methods Study
Authors: Sun Yuewen , Li Yuan , He Feng J. , Liu Hueiming , Sun Jingwen , Luo Rong , Guo Chunlei , Zhang Puhong 
Published: March 2022

BackgroundSalt reduction is a cost-effective, and rather challenging public health strategy for controlling chronic diseases. The AppSalt program is a school-based multi-component mobile health (mhealth) salt reduction program designed to tackle the high salt intake in China. This mixed-methods process evaluation was conducted to investigate the implementation of this program across sites, identify factors associated with the implementation, and collect evidence to optimize the intervention design for future scale-up.MethodsMixed methods were used sequentially to collect data regarding five process evaluation dimensions: fidelity, dose delivered, dose received, reach, and context. Quantitative data were collected during the intervention process. Participation rate of intervention activities was calculated and compared across cities. The quantitative data was used for the selection of representative intervention participants for the qualitative interviews. Qualitative data were collected in face-to-face semi-structured interviews with purposively selected students (n = 33), adult family members (n = 33), teachers (n = 9), heads of schools (n = 9), key informants from local health, and education departments (n = 8). Thematic analysis technique was applied to analyze the interview transcripts using NVivo. The qualitative data were triangulated with the quantitative data during the interpretation phase.ResultsThe total number of families recruited for the intervention was 1,124. The overall retention rate of the AppSalt program was 97%. The intervention was implemented to a high level of fidelity against the protocol. About 80% of intervention participants completed all the app-based salt reduction courses, with a significant difference across the three cities (Shijiazhuang: 95%; Luzhou: 73%; Yueyang: 64%). The smartphone app in this program was perceived as a feasible and engaging health education tool by most intervention participants and key stakeholders. Through the interviews with participants and key stakeholders, we identified some barriers to implementing this program at primary schools, including the left-behind children who usually live with their grandparents and have limited access of smartphones; perceived adverse effects of smartphones on children (e.g., eyesight damage); and overlooked health education curriculum at Chinese primary schools.ConclusionThis process evaluation demonstrated the feasibility and acceptability of using smartphone applications delivered through the education system to engage families in China to reduce excessive salt intake.Clinical Trial RegistrationThe AppSalt study was registered at www.chictr.org.cn, identifier: ChiCTR1800017553. The date of registration is August 3, 2018.
A School Intervention's Impact on Adolescents' Health-Related Knowledge and Behavior
Authors: Nagy-Pénzes Gabriella , Vincze Ferenc , Bíró Éva 
Published: March 2022

BackgroundMany factors can influence health behavior during adolescence, and the lifestyle of adolescents is associated with health behavior during adulthood. Therefore, their behavior can determine not only present, but also later health status.ObjectiveWe aimed to develop an intervention program to improve high school students' health behavior and to evaluate its effectiveness.MethodsWe performed our study at a secondary school in a rural town in East Hungary between 2016 and 2020. Sessions about healthy lifestyles were organized regularly for the intervention group to improve students' knowledge, to help them acquire the right skills and attitudes, and to shape their behavior accordingly. Data collection was carried out via self-administered, anonymous questionnaires (n = 192; boys = 49.5%; girls = 50.5%; age range: 14–16). To determine the intervention-specific effect, we took into account the differences between baseline and post-intervention status, and between the intervention and control groups using individual follow-up data. We used generalized estimating equations to assess the effectiveness of our health promotion program.ResultsOur health promotion program had a positive effect on the students' health-related knowledge and health behavior in the case of unhealthy eating, moderate to vigorous physical activity, and alcohol consumption.ConclusionOur findings suggest that school health promotion can be effective in knowledge transfer and lifestyle modification. To achieve a more positive impact on health behavior, preventive actions must use a complex approach during implementation.
Irinotecan (CPT-11) Treatment Induces Mild Gonadotoxicity
Authors: Levi Mattan , Ben-Aharon Irit , Shalgi Ruth 
Published: March 2022

Background:Gonadal toxicity following chemotherapy is an important issue among the population of young cancer survivors. The inhibitor of DNA topoisomerase I, irinotecan (CPT-11), is widely used for several cancer types. However, little is known about the effect of irinotecan on the fertility of both genders. Thus, the aim of the present study was to evaluate irinotecan gonadotoxicity, using a mouse model.MethodsMature male and female mice were injected intraperitoneally with either saline (), irinotecan (100 mg/kg) or cyclophosphamide (100 mg/kg); and sacrificed one week or three months later for an acute or long-term toxicity assessment, respectively. We used thorough and advanced fertility assessment by already established methods: Gonadal and epididymal weights, as well as sperm count and sperm motility were determined; serum anti-Müllerian hormone (AMH) was measured by ELISA. Immunohistochemistry (Ki-67), immunofluorescence (PCNA, CD34), terminal transferase-mediated deoxyuridine 5-triphosphate nick-end labeling (TUNEL) and computerized analysis were performed to examine gonadal proliferation, apoptosis and vascularization. qPCR was used to assess the amount of testicular spermatogonia (Id4 and Gafra1 mRNA) and ovarian primordial oocytes reserves (Sohlh2, Nobox and Figla mRNA).ResultsFemales: Irinotecan administration induced acute ovarian apoptosis and decreased vascularity, as well as a mild, statistically significant, long-term decrease in the number of growing follicles, ovarian weight, and ovarian reserve. Males: Irinotecan administration caused an acute testicular apoptosis and reduced testicular spermatogenesis, but had no effect on vascularity. Irinotecan induced long-term decrease of testicular weight, sperm count and testicular spermatogonia and caused elevated serum AMH.ConclusionOur findings imply a mild, though irreversible effect of irinotecan on mice gonads.
QM/MM Study of the H2 Formation on the Surface of a Water Ice Grain Doped With Formaldehyde: Molecular Dynamics and Reaction Kinetics
Authors: Kerkeni Boutheïna , Boukallaba Malek , Hechmi Mariem , Duflot Denis , Toubin Céline 
Published: March 2022

Formaldehyde has been widely observed in the icy mantle of interstellar grains. H2CO may be formed from successive hydrogenations of CO and may further contribute to the chemical complexity of the Interstellar medium (ISM) participating to heterogeneous reactions with colliding gas phase atoms. Within this context, Eley-Rideal and Langmuir-Hinshelwood rate constants of H2 formation on a formaldehyde doped amorphous water ice grain model of the ISM, were computed over a wide temperature range [15–2000 K]. We used classical molecular dynamics (MD) simulations to build the model of the H2CO doped ice surface. Then we studied theoretically by means of hybrid QM/MM ab initio and molecular mechanics methodology (ONIOM) H atoms abstraction from formaldehyde molecules and the H2 formation. Specifically, we investigate the reactivity of the gas phase H atom toward one formaldehyde molecule lying at one of the slab surfaces. The reaction path and the energetics are predicted, the mechanism is found to be exothermic by 14.89 kcal/mol and the barrier is 6.75 kcal/mol at the QM level CBS/DLPNO-CCSD(T)//ONIOM/aug-cc-pVTZ. We employ two approaches that take into account tunnelling and non-classical reflection effects by means of the Zero Curvature Tunnelling (ZCT), and the Small Curvature Tunnelling (SCT) which all provided comparable results to predict the kinetics of the reaction path. The rate constants show important quantum tunnelling effects at low temperatures when compared to rates obtained from the purely classical transition-state theory (TST) and from the canonical variational transition state theory (CVT). Corner cutting effects are highlighted in the SCT calculations by 4 to 5 orders of magnitude with respect to ZCT rate constants at low temperatures.
Clinical Features of Craniopharyngioma With Tumoral Hemorrhage: A Retrospective Case-Controlled Study
Authors: Chen Yusi , Hu Feng , Wang Junwen , Huang Kuan , Liu Weihua , Tan Yutang , Zhao Kai , Xiao Qungen , Lei Ting , Shu Kai 
Published: March 2022

BackgroundCraniopharyngioma (CP) with tumoral hemorrhage is a very rare syndrome presenting with various manifestation and unfavorable outcomes. The current retrospective study was performed to summarize the clinical features of CP with tumoral hemorrhage.MethodsIn this study, 185 patients with pathological diagnosis of CP (18 patients with hemorrhage) were enrolled. Clinical characteristics, radiological and surgical treatments, and post-operative complications were analyzed. In addition, the correlations between sexual hormones and tumor volume were explored.ResultsDrowsiness, acute syndrome, and pituitary deficiency were more frequent in patients with hemorrhage patients. Prothrombin time (PT) were higher in patients with hemorrhage. Luteinizing hormone (LH) and testosterone (T) were lower in male patients with hemorrhage. Post-operative electrolyte disturbances, hypothalamic syndrome, and death appeared more frequently in the hemorrhage group. Moreover, prolactin (PRL) and cortisol 8AM were found to be correlated with the volume of the tumor and the hematoma, respectively.ConclusionThe current study presented the clinical features of CP apoplexy from the aspects of clinical characteristics, radiography, surgical treatment, and post-operative complications. Patients with CP apoplexy could benefit from the proper processing of peritumoral hemorrhage and post-operative monitoring of the electrolyte.
The Global Status of Research in Ankle Fracture: A Bibliometric and Visualized Study
Authors: Zeng Jianshuang , Xu Cheng , Xu Gaoxiang , Wang Daofeng , Zhang Wupeng , Li Hua , Gan Xuewen , Xiong Ying , Li Jiantao , Zhang Licheng , Tang Peifu 
Published: March 2022

BackgroundAnkle fractures are common lower extremity fractures that pose a significant economic and social burden. This study analyzed the ankle fracture research literature between 2000 and 2021 to clarify the current status of ankle fracture research and predict future research trends.MethodsPublications related to ankle fractures published between 2000 and 2021 were retrieved from the Web of Science Core Collection. Then Bibliometric analysis and Visualized Study were performed by VOSviewer software.ResultsA total of 2656 publications were retrieved. The number of publications related to ankle fractures is increasing every year. The top countries and journals in terms of the total number of publications, number of citations, and H-index ranking were USA and foot and ankle int. Lorich DG had the most publications in this field. University of Amsterdam's research group had the biggest number of publications in this field. Co-occurrence analysis clustered the keywords into seven clusters: survival analysis and prognosis study, internal fixation treatment study, treatment study of combined deltoid ligament rupture, treatment study of combined inferior tibiofibular ligament injury, treatment study of posterior ankle fracture, treatment study of postoperative traumatic arthritis of ankle fracture, and treatment study of ankle injury in children.ConclusionsThe importance of ankle fractures is increasing year by year with the aging process, and the number of publications related to ankle fractures will not continue to increase in the future. Survival and prognosis studies, internal fixation studies, combined deltoid ligament rupture studies, and combined inferior tibiofibular ligament injury studies may become the future research hotspots in the field of ankle fractures.
Clinical Classification, Pregnancy Outcomes and Risk Factors Analysis of Severe Preeclampsia Complicated With HELLP Syndrome
Authors: Huang Hui , Liu Bo , Gao Xia , Wang Yunju 
Published: March 2022

PurposeTo investigate the clinical classification, pregnancy outcomes and risk factors of pregnant women with severe preeclampsia (SPE) complicated with HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.MethodsThe clinical data of 50 pregnant women diagnosed with SPE complicated with HELLP syndrome in our hospital from January 2014 to January 2021 were retrospectively analyzed, and they were selected as the observation group. An additional 50 maternities diagnosed with preeclampsia (PE) during the same period were selected as the control group. The clinical classification and pregnancy outcomes of pregnant women in the observation group were recorded. The age and gestational age of onset of pregnancy were recorded and compared between the two groups. Univariate analysis and multivariate logistic regression model were used to analyze the risk factors for its occurrence.ResultsAmong the 50 maternities in the observation group, there were 10 cases of type I, accounting for 20.00%; 35 cases of type II, accounting for 70.00%; 5 cases of type III, accounting for 10.00%. Partial 33 cases, the composition ratio of 66.00%; complete 17 cases, the composition ratio of 34.00%. Among the fetuses of 50 maternities in the observation group, 35 were premature, accounting for 70.00%; 13 had fetal growth restriction, accounting for 26.00%; and 2 died during perinatal period, accounting for 4.00%. Among the 50 maternities in the observation group, 48 cases were cesarean section, the composition ratio was 96.00%; 2 cases were induced labor, the composition ratio was 4.00%; there was no natural birth, the composition ratio was 0.00%. Univariate analysis showed that age, gestational age at onset, gestational age at termination of pregnancy, HGB, LDH, ALT, AST, TBIL, PLT, PT, and FIB were all associated with the occurrence of SPE complicated with HELLP syndrome (P &lt; 0.05). Multivariate logistic analysis showed that gestational age at onset, gestational age at termination of pregnancy, HGB, LDH, ALT, AST, TBIL, PLT, and FIB were independent risk factors for SPE complicated with HELLP syndrome (P &lt; 0.05).ConclusionSPE complicated with HELLP syndrome has significantly increased adverse pregnancy outcomes. Understanding its clinical classification is of great significance for the preventive application of platelet transfusion therapy and the selection of transfusion timing. Gestational age at onset and gestational age at termination of pregnancy are independent risk factors for its occurrence. Fully understanding the high-risk factors of HELLP syndrome, taking preventive measures in time, and carrying out targeted nursing can effectively improve the prognosis of pregnant women and reduce the risk of HELLP syndrome.
TUMBUH KEMBANG OPTIMAL DENGAN STIMULASI PERKEMBANGAN PADA BALITA
Authors: Sofiyanti Ida , Astuti Fitria Primi , Salafas Eti 
Published: March 2022

Perkembangan Bayi/Balita seharusnya sesuai dengan tahapan perkembangan. Stimulasi perkembangan hendaknya dilakukan secara rutin sehingga bayi/balita tidak mengalami keterlambatan. Jumlah Bayi/Balita di Kelurahan Candirejo per Oktober 2017 adalah 345 anak. Terdapat 5 posyandu dengan 25 kader posyandu. Kader dan orang tua bayi balita kurang mengetahui tahapan perkembangan dan stimulasi perkembangan yang harus dilakukan. Tujuan kegiatan pengabdian masyarakat ini adalah memberikan penyuluhan tentang stimulasi perkembangan pada balita sesuai dengan tahapan perkembangan. Metode kegiatan dilakukan dengan dua tahap yaitu penyuluhan tentang stimulasi perkembangan bayi/balita pada kader posyandu dan pelaksanaan stimulasi perkembangan oleh orangtua. Sasaran kegiatan ini adalah kader posyandu Kelurahan Candirejo dan orangtua/pengasuh. Alat ukur yang digunakan adalah kuesioner pengetahuan kaderPosyandutentang stimulasi perkembangan dan kartu kendali.Hasil kegiatan ini yaitu adanya peningkatan rata-rata pengetahuan kader tentang stimulasi perkembangan sebanyak 2 angka dengan nilai minimal 6 dan maksimal 10. Stimulasi yang harus dilakukan oleh orangtua/pengasuh sebagian besar pada aspek bahasa dan personal sosial. Orangtua/pengasuh melakukan stimulasi perkembangan setiap hari. Diharapkan kader Posyandu selalu memberikan penyuluhan stimulasi sesuai dengan tahapan perkembangan dan melaporkan ke bidan desa apabila menemukan keterlambatan perkembangan pada balita di wilayah Posyandunya. Orangtua/pengasuh disarankan untuk selalu melakukan stimulasi perkembangan sesuai dengan tahapan perkembangan anak. Kata Kunci : Stimulasi Perkembangan, Kader Posyandu, Bayi/Balita
The Description of Stress Levels among Medical Students
Authors: Ndoen Della Rovita , Anakaka Dian Lestari , Aipipidely Diana 
Published: March 2022

Abstract. Stress is the body’s reaction to any change that requires an adjustment or response. The body reacts to these changes with physical, mental, and emotional responses. This research aims to comprehend the stress levels of students in the medical faculty of Nusa Cendana University, Kupang based on sex and years. The design in this research is descriptive quantitative by collecting data used stress scale (consisted of 40 items) compiled by the researcher. The trial results of the measuring instruments shows that the value of Cronbach’s Alpha is 0.936. The participants are 173 students. The result shows that medical students have a moderate stress level that seen from the percentage is 85.5%, and female students have a higher stress level than male based on sex, then last year students have a higher stress level than the other students based on year.
Abstrak. Stres adalah reaksi tubuh terhadap setiap perubahan yang membutuhkan penyesuaian atau respons. Tubuh bereaksi terhadap perubahan ini dengan tanggapan fisik, mental, dan emosional. Penelitian ini bertujuan untuk mengetahui tingkat stres mahasiswa Fakultas Kedokteran Universitas Nusa Cendana Kupang berdasarkan jenis kelamin dan umur. Desain dalam penelitian ini adalah deskriptif kuantitatif dengan pengumpulan data menggunakan skala stres (terdiri dari 40 item) yang disusun oleh peneliti. Hasil uji coba alat ukur menunjukkan bahwa nilai Cronbach's Alpha adalah 0,936. Pesertanya 173 siswa. Hasil penelitian menunjukkan bahwa mahasiswa kedokteran memiliki tingkat stres yang sedang dilihat dari persentase 85,5%, dan mahasiswa perempuan memiliki tingkat stres yang lebih tinggi dibandingkan laki-laki berdasarkan jenis kelamin, maka tahun lalu mahasiswa memiliki tingkat stres yang lebih tinggi dibandingkan mahasiswa lain berdasarkan tahun.