bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug resistance-associated mutations in Plasmodium UBP-1 disrupt ubiquitin hydrolysis
Authors: Smith Cameron , Henrici Ryan , Karpiyevich Maryia , Ansbro Megan R. , Hoshizaki Johanna , van der Heden van Noort Gerbrand J. , Ascher David B. , Sutherland Colin J. , Lee Marcus C.S. , Artavanis-Tsakonas Katerina 
Published: September 2022

ABSTRACTDeubiquitinating enzymes function to cleave ubiquitin moieties from modified proteins, serving to maintain the pool of free ubiquitin in the cell while simultaneously impacting the fate and function of a target protein. Like all eukaryotes, Plasmodium parasites rely on the dynamic addition and removal of ubiquitin for their own growth and survival. While humans possess around 100 DUBs, Plasmodium contains ∼20 putative ubiquitin hydrolases, many of which bear little to no resemblance to those of other organisms. In this study, we characterize PfUBP-1, a large ubiquitin hydrolase unique to Plasmodium spp that has been linked to endocytosis and drug resistance. We demonstrate its ubiquitin activity, linkage specificity and assess the repercussions of point mutations associated with drug resistance on catalytic activity and parasite fitness.
Proposal of BPMN extension with a view to effective modeling of clinical pathways
Authors: Szelągowski Marek , Biernacki Piotr , Berniak-Woźny Justyna , Lipinski Cezary Radosław 
Published: September 2022

PurposeThe aim of the article is to propose BPMN extensions that facilitate the modeling of Clinical Pathways in a way that enables for various groups of users, the transfer of a much wider range of information in the form of process models without compromising their readability and usefulness.Design/methodology/approachThe paper uses the design science research methodology (DSRM) and covers phases of a design-oriented research project extending BPMN notation for clinical pathway modeling.FindingsThe article proposes extensions of BPMN in 5 areas, enabling standardization of the description of business processes of different natures and complexity and in turn meeting the needs and requirements of modeling clinical pathways and, more broadly speaking, knowledge-intensive business processes (kiBPs) in general. As shown by the evaluation carried out among medical personnel, the proposed extensions allow for the readable transfer of a considerably larger body of information relevant to the planned, conducted and assessed therapy (kiBPs) than the current BPMN 2.0 standard.Originality/valueThe BPMN extensions proposed in the article fill the gaps in this notation and do not require users to know many notations, which in practice is unrealistic. Defined extensions to the BPMN specification makes it possible to standardise the description of processes of different natures and levels of complexity. In this way, both simplified models (and views of models) dedicated to users unfamiliar with BPMN and models (or views) using advanced possibilities provided by BPMN can be based on one standard, even if they use only a small part of its possibilities.
Supply chain resilience: the role of supplier development in the form of contract farming in fast-food outlets in Zimbabwe
Authors: Mukucha Paul , Chari Felix 
Published: September 2022

PurposeThe study sought to determine the possibility of supplier development in the form of contract farming as a determinant of supply chain resilience in fast-food outlets. This is against the background of the restaurant having been designated as one of the industries that remained operational when the other industries were affected by the two-decade-long economic meltdown and more recently COVID-19 pandemic.Design/methodology/approachData were collected using questionnaires from the consenting restaurants with the most senior procurement personnel in target restaurants as the informants and analysed using analysis of moment structures (AMOS) software.FindingsThe results revealed that indeed supplier development in the form of contract farming leads to supply chain resilience as indicated by improved supply chain visibility, supply chain flexibility, and supply chain redundancy. Fast-food restaurant businesses that have not yet adopted supplier development in the form of contract farming are therefore encouraged to adopt it as a way of enhancing their resilience to traditional supply chain disruptions such as transport shortages, droughts, and more recently COVID-19 pandemic.Originality/valueIt is to the best knowledge of these researchers, that no studies have attempted to analyse the three drivers of supply chain resilience, namely supply chain redundancy, supply chain flexibility, and supply chain visibility in a single study and link them to a single antecedent.
The effects of visual technology on price discovery for residential listings and transactions
Authors: Ong Seow Eng , Wong Woei Chyuan , Wang Davin , Lai Choon Peng 
Published: September 2022

Purpose
The purpose of this paper is to examine the effect of visual technology on the price discovery process in listings of residential properties in Singapore from 2015 to 2018.

Design/methodology/approach
The authors empirically model the effects of 360 virtual tours and drone video on four dimensions in price discovery – buyers’ arrival rate, sale probability, transaction prices and time-on-market – using a comprehensive data set for the residential properties in Singapore.

Findings
The analysis shows that the availability of virtual tours or drone video in a listing increases the arrival rate from potential buyers, the probability of a successful sale and the selling price. These findings are consistent with the hypothesis that technologically enhanced tools improve the quality of information and the marketability of property. However, listings with virtual tours tend to be associated with longer marketing time, which is consistent with the prediction of the information overload hypothesis.

Research limitations/implications
This paper extends the housing and price discovery literature by examining how technologically enabled new information affects property transactions.

Originality/value
To the best of the authors’ knowledge, this is the first paper to consider the impact of drone video on property market outcome.
Micro-takāful scheme for the protection of houses belonging to low-income groups in Malaysia
Authors: Mohd Fauzi Puteri Nur Farah Naadia , Laldin Mohamad Akram 
Published: September 2022

PurposeThis study aims to assess the availability of micro-takāful (micro-Islamic insurance) schemes for the protection of houses belonging to low-income groups in Malaysia.Design/methodology/approachThe study is conducted via desk research and interview discussions with representatives from takāful operators and key stakeholders.FindingsFindings of the study confirm the importance of micro-takāful as a scheme for the protection of low-income groups. Micro-takāful schemes in Malaysia are, however, skewed towards the protection of health, life and family. The study finds little industry interest in the provision of micro-takāful schemes for the protection of houses for low-income groups. This represents another important area that takāful operators should take into consideration in their planning.Research limitations/implicationsThe paper will help the Majlis Agama Islam Negeri-Negeri (MAINs), the regulator, takāful operators and government agencies such as Jabatan Wakaf, Zakat dan Haji (JAWHAR) to generate awareness and promote the offering of micro-takāful schemes for the protection of houses belonging to low-income groups in Malaysia.Practical implicationsIn light of the limited availability of micro-takāful schemes for the protection of houses for low-income groups, this study argues that takāful operators should offer and promote them.Social implicationsThe study is significant for fulfilling the need of low-income groups in Malaysia to protect their houses in the event of catastrophes so that they will not suffer significant losses. Rather, micro-takāful will assist them in improving their standard of living.Originality/valueThis study promotes the idea that it is essential to facilitate the low-income groups with appropriate coverage made available to them; micro-takāful schemes in protecting their houses and home contents, should any defined calamities occur. The outcomes are necessary for further development of micro-takāful models, specifically for the protection of properties. The developed model shall be proposed for application in the Malaysian takāful and housing industry to facilitate low-income groups to obtain protection for their household and home contents.
HRM practices and employee engagement: role of personal resources- a study among nurses
Authors: Jose Geetha , P.M. Nimmi , Kuriakose Vijay 
Published: September 2022

PurposeThe study aims to look into the mechanism by which perceived human resource management (HRM) practices impact nurses' engagement, by specifically looking into the role of psychological availability and psychological safety.Design/methodology/approachA cross-sectional questionnaire survey was conducted among nurses (n = 465). Data were collected from nurses of National Accreditation Board for Hospitals and Healthcare Providers (NABH) accredited hospitals by employing two stage sampling.FindingsResults indicate significant positive association between HRM practices and employee engagement. Role of psychological safety and psychological availability as mediators was also confirmed. The study supported the proposition that HRM practices affected employee engagement through psychological safety and then psychological availability thus approving serial mediation.Originality/valueThis research also contributes to a more comprehensive understanding of the ways to achieve employees' psychological safety, availability, and thus nurse engagement.
Factors influencing the adoption of improved rice varieties: a case of smallholder farmers in Quang Dien district of Vietnam
Authors: Hoang Hung Gia , Nguyen Dung Trong 
Published: September 2022

PurposeThe purpose of this study is to examine factors that affect smallholders' adoption of improved rice varieties in Vietnam.Design/methodology/approachThis study used a cross-sectional survey design. A random sample size of 257 was drawn from a total of 725 smallholders. Descriptive statistics and a binary logistic regression were used to analyse the data.FindingsThis study concludes that younger smallholders who participate in credit and training programs have a high level of education, receive government support, have both owned and rented land for growing rice and those who have a larger farm size have a greater tendency to adopt improved rice varieties. In addition, if improved rice varieties have higher productivity potential, palatability and marketability compared with the traditional ones as perceived by smallholders and seed of these rice varieties are available in local markets, then they are likely to be adopted by smallholders.Research limitations/implicationsA combination of socio-technological characteristics of smallholders should be considered when promoting smallholders' adoption of improved rice varieties and when choosing agricultural extension strategies to improve small-scale farmers' uptake of improved crop varieties in developing countries.Originality/valueThis research provides important understanding of the determinants of smallholders' adoption of improved rice varieties and highlights factors that need to be considered when designing policies to enhance the uptake of improved rice varieties in developing countries.
Exploring learning opportunities for students in open data portal use across data literacy levels
Authors: Li Ak Wai , Sinnamon Luanne S. , Kopak Rick 
Published: September 2022

Purpose
The purpose of this study is to explore open data portals as data literacy learning environments. The authors examined the obstacles faced and strategies used by university students as non-expert open data portal users with different levels of data literacy, to inform the design of portals intended to scaffold informal and situated learning.

Design/methodology/approach
The authors conducted an observational user study, in which 14 student participants grouped by self-reported data literacy measures carried out assigned tasks in an open data portal. Data were collected through screen capture, think-aloud protocols and post-session interviews.

Findings
Participants experienced numerous challenges in finding and using data, with some variation shown between the different literacy groups. The higher data literacy group primarily faced challenges using unfamiliar tools, which may be addressed by improving system usability, while the lower data literacy group struggled due to gaps in basic understanding, which may be addressed by increasing point of need instruction and guidance. Participants used several learning strategies but primarily relied upon trial and error, which was less effective for low data literacy users.

Originality/value
This study is unique in comparing open data portal use among adult students across data literacy levels through an empirical user study. It contributes methodologically by proposing an instrument for data literacy assessment. It offers a novel perspective on information systems as sites for informal learning and skills development, beyond the immediate goals of system use, and offers concrete suggestions for the future design of open data portals for students and non-expert, citizen users.
Does financial development affect human capital? Evidence from Vietnam
Authors: Ha Nguyen Minh , Hoang Ngoc Bui , Vo Duc Hong 
Published: September 2022

Purpose
The purpose of this study is to explore the relationship among financial development (FD), economic growth, urbanization and human capital (HC) in Vietnam.

Design/methodology/approach
This study uses various wavelet tools, including wavelet coherence, wavelet correlation and scale-by-scale Granger causality test, to re-visit the lead–lag structure among economic growth, FD, urbanization and HC in Vietnam from 1980 to 2017.

Findings
The main findings indicate that economic growth and urbanization improve HC at the medium and low frequencies, whereas FD negatively affects HC from 1989 to 2017. Furthermore, the scale-by-scale Granger causality results confirm a uni-directional causality relationship between economic growth to HC at low and high frequencies. In contrast, a bi-directional causality relationship between urbanization and HC is found in the long run.

Research limitations/implications
Policy implications have emerged based on the empirical results from this study. The Vietnamese Government should continue supporting economic integration, implementing investment promotion policies and focussing on foreign direct investment using green technologies.

Originality/value
The impact of FD on HC at different time scales has largely been ignored in Vietnam. This study substantially contributes to the existing literature regarding HC and FD. This analysis is one of the earliest attempts to examine the effects of economic indicators on HC in the time-frequency analysis.
Family influence and succession strategies in private businesses at the cusp of leadership change: comparison between family firms and lone founder enterprises
Authors: Motylska-Kuzma Anna , Szymanska Izabela , Safin Krzysztof 
Published: September 2022

PurposeThis paper investigates the impact of family influence measured by the F-PEC scale on private enterprise (both family firms and lone founders) leadership succession strategy.Design/methodology/approachThe research dataset is comprised of 390 private enterprises whose head offices were situated in the voivodeships of Lower Silesia and Wielkopolska in Poland. The authors collected data through CAPI (computer-assisted personal interviewing) method, as well as through comprehensive, structured interviews with company owners. Data were analysed using hierarchical logistic regression for each type of succession strategy.FindingsThe results suggest that increased family influence does not necessarily lead to intra-family leadership succession in private enterprises. Importantly, a range of findings contradicted authors' predictions. The relationship between the overall F-PEC scale values signifying the multi-faceted family influence over the business and the choice of internal successor was weakly negative for the total sample; also, the higher the overlap between family and business values and the higher the commitment to family business, as evidenced by the Culture subscale, the lower was the occurrence of intra-family successor choice in the population of lone founders. The Culture subscale also increased the prevalence of lack of succession planning in the sample of lone founders.Originality/valueWhile several studies suggests that family firms may be more prone to choose an intra-family succession scenario, it remains unclear how lower levels of business and succession experience, may influence the successor choice. Indeed, some studies suggest that a strong family influence over a business, may stimulate family firms to choose a family outsider as a business leader. Therefore, the key contribution of this study is contextualizing the response to an ongoing succession debate. This study investigates the strategic choices of companies in the first generation of ownership operating in Poland, which serves as an example of a post-transition economy. While the characteristics of this economic environment may be unique, the authors discuss how the surprising findings may add to the understanding of the general succession processes present in private enterprises.
GSK3β inhibitor TDZD8 ameliorates brain damage through both ROS scavenging and inhibition of apoptosis in hyperglycaemic subarachnoid haemorrhage rats
Authors: Hao Shuangying , Chen Xingying , Zhang Dingding , Song Wenting , Zhou Yan , Yuan Zhiqing , Liu Zhiqiang , Yue Xiaojing , Yuan Shuai 
Published: September 2022

AbstractHyperglycaemia is known to be associated with unfavourable outcomes in subarachnoid haemorrhage (SAH), but the pathogenic mechanism is unclear, and there is also a lack of effective therapeutic drugs in clinical practice. Phosphorylation of GSK3β at serine 9 can inhibit its activity to further worsen SAH. The aim of the present study was to evaluate the protective effect and the potential mechanism of the GSK3β inhibitor TDZD8 on brain injury in a hyperglycaemic SAH rat model. Hyperglycaemia was induced by intraperitoneal injection of streptozocin for 3 days. The SAH model was established by injecting fresh autologous femoral artery blood into the prechiasmatic cistern. p‐GSK3β (Ser9) expression was induced by intraperitoneal injection of TDZD8 (30 min post‐SAH). The expression levels of GSK3β, p‐GSK3β, SOD1/2, caspase 3, Bax and Bcl‐2 were detected by western blot analysis. Terminal deoxynucleotidyl transferase dUTP nick end‐labelling (TUNEL) staining was used to detect neuronal apoptosis of basal temporal lobe. Neurological scores were calculated to determine behavioural recovery. Neuronal survival was detected by Nissl staining. Hyperglycaemia significantly decreased p‐GSK3β expression, further exacerbated neurobehavioural deficits and increased oxidative stress and neuronal apoptosis in the brain after SAH compared to normal glycaemic SAH rats and hyperglycaemic rats. In addition, hyperglycaemic SAH rats had obvious oxidative stress and apoptosis. However, TDZD8 effectively decreased cleaved caspase 3 expression and TUNEL‐positive cells and increased the Bcl2/Bax ratio, expression of SOD1/2 and activity of superoxide dismutase (SOD) enzyme compared with hyperglycaemic SAH rats. The GSK3β inhibitor TDZD8 has therapeutic potential for hyperglycaemic SAH. The neuroprotective effect of TDZD8 appears to be mediated through its antioxidative and antiapoptotic activity.
Family functioning in the Mozambican context: Results of a psychometric study of the SCORE‐15 scale
Authors: Bié Domingos , Narciso Isabel , Crespo Carla , Roberto Magda 
Published: September 2022

AbstractThe Systemic Clinical Outcome and Routine Evaluation (SCORE)‐15 scale is a widely used tool for measuring family functioning across three dimensions: strengths and adaptability, overwhelmed by difficulties, and disrupted communication. This study assessed the factorial validity and reliability of the SCORE‐15 in the Mozambican context. Four‐hundred university students completed the SCORE‐15 scale and the depression, anxiety and hostility subscales of the Brief Symptom Inventory (BSI). The confirmatory factor analysis supported a three‐factor structure that presented adequate model fit and reliability indexes. Poorer family functioning was correlated with psychopathological symptoms, except for the association between depression and disrupted communication. Women revealed higher levels of disrupted communication, while being single was associated with lower levels of being overwhelmed by difficulties and disrupted communication. Age was positively associated with being overwhelmed by difficulties and disrupted communication. The Mozambican version of the SCORE‐15 showed good factorial validity and reliability and can be used in this national diverse socio‐cultural context.
Practitioner points

SCORE‐15 is a systemic self‐report measure for routine clinical use and research on family relationships.

In this study, SCORE‐15 showed evidence of reliability and validity in Mozambique.
Lin28A alleviates ovariectomy‐induced osteoporosis through activation of the AMP‐activated protein kinase pathway in rats
Authors: Cai Liang , Gao Zhanwang , Gu Zhiping 
Published: September 2022

AbstractAimTo investigate the role of Lin28A in ovariectomy‐induced osteoporosis and to elucidate the underlying molecular mechanism.MethodsBilateral ovariectomy was conducted to generate an ovariectomy (OVX) rat model. Western blotting was performed to assess the relative expression levels of Lin28A, osteocalcin (OCN), runt‐related transcription factor 2 (RUNX2), adenosine monophosphate‐activated protein kinase (AMPK) and phosphorylated AMPK (p‐AMPK) proteins. Enzyme‐linked immunosorbent assays were performed to detect the serum levels of calcium, E2, alkaline phosphatase (ALP) and interleukin (IL)‐1β. Three‐point bending test was used to assess biomechanical parameters of left femoral diaphysis. Hematoxylin and eosin (HE) staining was conducted to detect the trabecular structure of bone tissue. Dihydroethidium assay kit was used to measure the intracellular reactive oxygen species (ROS) level in osteoclasts. Alizarin red staining revealed the calcium deposit in bone marrow stromal cells (BMSC).ResultsThe expression levels of Lin28A, OCN, RUNX2, AMPK and p‐AMPK proteins were significantly decreased in OVX rats. The serum levels of calcium, E2, ALP and IL‐1β were significantly declined in OVX rats. Biomechanical parameters of left femoral diaphysis were significantly decreased in OVX rats. OVX‐induced trabecular abnormalities. ROS level was dramatically increased in the bone tissue of OVX rats, and calcium deposit was dramatically decreased in BMSC cells of OVX rats. These effects induced by OVX could be prevented by overexpression of Lin28A.ConclusionLin28A alleviates ovariectomy‐induced osteoporosis through activation of AMPK pathway in rats.