bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relative Handgrip Strength and Incidence of Hypertension: A Case-Cohort Study From Ravansar Non-Communicable Diseases Cohort
Authors: Najafi Farid , Darbandi Mitra , Rezaeian Shahab , Hamzeh Behrooz , Moradinazar Mehdi , Shakiba Ebrahim , Pasdar Yahya 
Published: September 2022

Background: The present study assessed the association between relative handgrip strength (RHGS) and hypertension incidence in healthy adults. Methods: We performed a case-cohort study on 3784 participants from Ravansar Non-Communicable Diseases cohort study. The absolute HGS was measured using a digital dynamometer. Hypertension was defined as systolic/diastolic blood pressure ≥140/90 mm Hg and/or use of antihypertensive medications. Cox regression analysis was utilized to estimate hazard ratios of incident hypertension events with RHGS. Results: Physical activity was significantly higher in the participants with hypertension compared with nonhypertensive participants (P < .001). High-level physical activity in the subjects with lower, middle, and upper RHGS was 19.6%, 33.1%, and 47.3%, respectively (P < .001). RHGS was significantly higher in individuals with greater skeletal muscle mass (P < .001). The men and women with the upper RHGS, had an 80% (hazard ratio: 0.2; 95% confidence interval, 0.1–0.3) and 70% (hazard ratio: 0.3; 95% confidence interval, 0.1–1.2), were lower risk of hypertension compared with those with the lower RHGS, respectively. This association remains significant after adjustment for confounding factors in men. Conclusion: The study demonstrated that middle and upper levels of RHGS were associated with a lower risk of hypertension incidence. RHGS may be a protective factor for hypertension. We suggested muscle strengthening exercises.
Comparative analysis of the health status of military police officers and firefighters: a cross-sectional study in the State of Paraná, Brazil
Authors: Santos Alexandra Ramos dos , Ihlenfeld Mauro Fernando Kürten , Olandoski Márcia , Barreto Fellype Carvalho 
Published: September 2022

ObjectivesTo evaluate the health-condition of military police officers and firefighters. To identify risk factors for not being medically ready for duty.DesignCross-sectional study.SettingData were extracted from medical records during annual periodic health assessments of police officers and firefighters serving with the military police in Paraná, Brazil.Participants6621 police officers (5927 men and 694 women) and 1347 firefighters (1257 men and 90 women) who underwent health assessments between July 2018 and June 2019 were analysed. Pregnant women were excluded.Outcome measuresData included variables such as sex, age, anthropometric measurements, lifestyle, comorbidities and laboratory tests. Multiple logistic regression was used to estimate the probability of not being medically ready for active duty.ResultsOverall, police officers had worse health status than firefighters and greater prevalence of overweight and obesity, regardless of sex. Musculoskeletal diseases were the most commonly reported disease by police officers and firefighters of both sexes. Among men, hypertension was the second most prevalent disease, followed by psychiatric diseases and dyslipidaemia. Among women, psychiatric diseases were the second most prevalent. Male police officers ≥40 years old presented the highest probability of not being considered ready for duty (40.1%). The probability of male police officers between the ages of 31 and 40 not being ready was similar to that for male firefighters >40 years old. There was a higher chance of not being medically ready professionals with diseases such as diabetes mellitus (OR 2.95, 95% CI 1.97 to 5.03), dyslipidaemia (OR 2.65, 95% CI 1.96 to 3.58), hypertension (OR 2.29, 95% CI 1.85 to 4.70), high total cholesterol (OR 2.16, 95% CI 1.93 to 2.42), and heart disease (OR 2.13, 95% CI 1.32 to 3.45).ConclusionsThere was a high prevalence of chronic diseases and modifiable cardiovascular risk factors among police officers and firefighters. Healthy protective measures should be offered frequently, particularly to police officers at an earlier age.
Pre-emptive oral cholera vaccine (OCV) mass vaccination campaign in Cuamba District, Niassa Province, Mozambique: feasibility, vaccination coverage and delivery costs using CholTool
Authors: Elias Chitio Jucunú J , Baltazar Cynthia S , Langa José Paulo , Baloi Liliana Dengo , Mboane Ramos B J , Manuel José Alberto , Assane Sadate , Omar Alide , Manso Mariana , Capitine Igor , Van Rensburg Craig , Luiz Naira , Mogasale Vittal , Marks Florian , Park Se Eun , Beck Namseon S 
Published: September 2022

IntroductionMozambique suffers from regular floods along its principal river basins and periodic cyclones that resulted in several cholera epidemics during the last decades. Cholera outbreaks in the recent 5 years affected particularly the northern provinces of the country including Nampula and Niassa provinces. A pre-emptive oral cholera vaccine (OCV) mass vaccination campaign was conducted in Cuamba District, Niassa Province, and the feasibility, costs, and vaccination coverage assessed.MethodsWHO prequalified OCV (Euvichol-Plus), a killed whole-cell bivalent vaccine containingVibrio choleraeO1 (classical and El Tor) and O139, was administered in two doses with a 15-day interval during 7–31 August 2018, targeting around 180 000 people aged above 1 year in Cuamba District. Microplanning, community sensitisation, and training of local public health professionals and field enumerators were conducted. Feasibility and costs of vaccination were assessed using CholTool. Vaccination coverage and barriers were assessed through community surveys.ResultsThe administrative coverage of the first and second rounds of the campaign were 98.9% (194 581) and 98.8% (194 325), respectively, based on the available population data that estimated total 196 652 inhabitants in the target area. The vaccination coverage survey exhibited 75.9% (±2.2%) and 68.5% (±3.3%) coverage for the first and second rounds, respectively. Overall, 60.4% (±3.4%) of the target population received full two doses of OCV. Barriers to vaccination included incompatibility between working hours and campaign time. No severe adverse events were notified. The total financial cost per dose delivered was US$0.60 without vaccine cost and US$1.98 including vaccine costs.ConclusionThe pre-emptive OCV mass vaccination campaign in remote setting in Mozambique was feasible with reasonable full-dose vaccination coverage to confer sufficient herd immunity for at least the next 3 to 5 years. The delivery cost estimate indicates that the OCV campaign is affordable as it is comparable with Gavi’s operational support for vaccination campaigns.
Adductor Strengthening Programme is successfully adopted but frequently modified in Norwegian male professional football teams: a cross-sectional study
Authors: Stensø Joakim , Andersen Thor Einar , Harøy Joar 
Published: September 2022

ObjectivesGroin injuries represent a substantial problem in male football, with the Adductor Strengthening Programme (ASP) being the only exercise programme demonstrated to significantly reduce the risk of groin problems. We aimed first, to use the Reach Adoption Effectiveness Implementation Maintenance (RE-AIM) framework to investigate attitudes, beliefs and behaviour to the ASP among primary delivery agents of injury prevention exercises in Norwegian male professional football teams. Second, we aimed to identify a real-world application of the ASP protocol used in a professional team setting.DesignA descriptive cross-sectional survey, using a questionnaire designed to cover all five dimensions of the RE-AIM framework.SettingThe top two divisions of Norwegian male professional football.Participants32 primary injury prevention delivery agents.Primary and secondary outcome measuresPrimarily, the proportion of respondents being aware of the ASP and its effect; having adopted it; having implemented it as intended; and considering maintaining using it. Secondary, the most often used ASP modifications.ResultsTwenty-nine (91%) participants responded. All (100%) respondents were aware of the ASP and its injury preventive effect. The two most stated reasons for using the ASP were its injury preventive effect and that it does not require equipment. The ASP was adopted by all (100%) delivery agents, but only 10% used it in accordance with the original protocol. The main modifications were that the players in 72% of the teams were instructed to perform a non-progressive number of repetitions during pre-season, and in 86% of the teams instructed to perform more sets, but fewer repetitions per set, during in season. In total, 97% of the delivery agents planned to continue using the ASP.ConclusionThe delivery agents have positive attitudes and beliefs to the ASP, but they frequently modify it. We identified and reported a real-world application of the ASP protocol.
Emergency care for older people living with frailty: patient and carer perspectives
Authors: Regen Emma , Phelps Kay , van Oppen James David , Riley Peter , Lalseta Jagruti , Martin Graham , Mason Suzanne M , Conroy Simon 
Published: September 2022

BackgroundLittle is known about how frailty impacts on older people’s experiences of emergency care, despite patient experience being essential to providing person-centred care. This qualitative study reports on the experiences of older people with frailty in the ED and their and their carers’ preferences for emergency care.MethodsOlder people (aged 75+ years) who were at least mildly frail and/or their carers, with current or recent experience of emergency care, were recruited from three EDs in England between January and June 2019. Data were collected via semi-structured in-depth interviews which explored participants’ views on their recent experience of emergency care and their priorities and preferred outcomes. Interviews were audio-recorded, transcribed verbatim and analysed following the principles of the Framework approach.ResultsForty participants were interviewed: 24 patients and 16 carers who, between them, described ED attendances for 28 patients across the three sites. Often informed by previous negative experiences, there was a strong desire to avoid conveyance to EDs, and a sense of helplessness or acquiescence to attend. Although staff attitudes were on the whole seen as positive, the ED experience was dominated by negative experiences relating to very basic issues such as a lack of help with eating, drinking, toileting and discomfort from long waits on hard trolleys. Participants reported that communication and involvement in decision making could be improved, including involving next of kin, who were viewed as critical to supporting vulnerable older people during sometimes very protracted waits.ConclusionFrailty reflects a vulnerability and a need for support in basic activities of daily living, which EDs in this study, and perhaps more widely, are not set up to provide. Changes at the levels of clinical practice and service design are required to deliver even the most basic care for older people with frailty in the ED environment.
Randomised, controlled crossover trial of intermittent and continuous transcutaneous electrical stimulation of the genioglossus muscle for obstructive sleep apnoea
Authors: Wu Xiaofeng , Zhao Dong , Hu Weihua , Zheng Zhishui , Zha Shiqian , Zhang Qingfeng , Hu Ke 
Published: September 2022

PurposeContinuous transcutaneous electrical stimulation (CTES) of the genioglossus muscle may benefit patients with obstructive sleep apnoea (OSA). However, the therapeutic value of intermittent transcutaneous electrical stimulation (ITES) for OSA is unclear.MethodsThis was a randomised, controlled, crossover study to compare the effects of ITES and CTES of the genioglossus muscle. Over three single-night sessions, participants were alternately subjected to three genioglossus stimulation modalities during sleep (sham, CTES and ITES). The apnoea-hypopnoea index (AHI) and oxygen desaturation index (ODI) were used for OSA diagnosis and to evaluate efficacy. A responder was defined as an individual with a ≥50% reduction in AHI together with <10 AHI events per hour and/or an ODI reduction of ≥25% between sham stimulation and electrical stimulation nights.ResultsFifteen men with OSA completed the study. Compared with sham, the median AHI with ITES decreased by 13.3 events/hour (95% CI 3.1 to 23.5, p=0.030) and by 7.3 events/hour (95% CI −3.9 to 18.5, p=0.825) with CTES. The median ODI was reduced by 9.25 events/hour (95% CI 0.5 to 18.0) with ITES and 3.3 events/hour (95% CI −5.6 to 12.2) with CTES; however, there was no significant difference between groups. Furthermore, ITES outperformed CTES with respect to longest apnoea duration (median (95% CI), 9.5 (0.0 to 19.0), p=0.011)) and the highest sleep efficiency (12.2 (2.7 to 21.7), p=0.009). Of the 15 participants, 8 responded to ITES and 3 responded to CTES (p=0.058), of whom all eight cases and two out of three cases had ODIs <5 events/hour, respectively. All participants tolerated ITES well.ConclusionsITES improved upper airway obstruction in patients with OSA, suggesting that further prospective validation of the intermittent approach is warranted.Trial registration numberChiCTR2100050138.
Analyzing powers at low nucleon–nucleon relative energies in proton–deuteron breakup reaction
Authors: Mohammadi-Dadkan M. , Amir-Ahmadi H. R. , Bayat M. T. , Deltuva A. , Eslami-Kalantari M. , Golak J. , Kalantar-Nayestanaki N. , Kistryn St. , Kozela A. , Mardanpour H. , Mehmandoost-Khajeh-dad A. A. , Messchendorp J. G. , Ramazani-Moghaddam-Arani A. , Ramazani-Sharifabadi R. , Skibiński R. , Stephan E. , Tavakoli-Zaniani H. , Witała H. 
Published: September 2022

AbstractVector analyzing powers for the $$d(\vec {p},pp)n$$

d
(

p
→

,
p
p
)
n

reaction have been measured at KVI for different kinematical configurations using a polarized proton beam with an energy of 190 MeV. We compared our data with different theoretical calculations at extremely low relative energies of the proton–proton and proton–neutron systems in the final state. For the proton–neutron case, we used the information of the two detected protons in the final state in which one of them scattered to an angle smaller than $$40^{\circ }$$

40
∘

and the other one to an angle larger than $$100^{\circ }$$

100
∘

in the laboratory frame. We extrapolated our measurements towards a kinematical configuration to a vanishing relative energy. Our results show that none of the theoretical models presented here is able to reproduce experimental data for the proton–proton case at very low relative energies. For the proton–neutron case, we were not able to provide a reliable extrapolation to small relative energies of less than 1 MeV. Present results are the basis for future investigations of spin-isospin dependencies in the nuclear many-body force.
Association of Plasma Anion Gap with 28-Day Inhospital Mortality and 1-Year Mortality of Patients with Alcohol Use Disorder at ICU Admission: A Retrospective Cohort Study
Authors: Pan Yu , Miao Xiaoyang , Jin Ou , Pan Jingye , Dong Yihua 
Published: September 2022

Background. Alcohol use disorder (AUD) is common in critically ill patients. Plasma anion gap (AG) was known as a feasible parameter and was associated with outcomes of various diseases. This study is intended to explore whether AG is related to 28-day inhospital mortality and 1-year mortality of critically ill patients with AUD. Method. We extracted data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The association of plasma AG with 28-day inhospital mortality and 1-year mortality of critically ill AUD patients was assessed using Cox proportional hazard regression models and stratification analyses, allowing AG as a time-varying covariate in the models. To evaluate the accuracy of AG in predicting different endpoints, receiver operator characteristic (ROC) curves were used. Result. Among the 3993 critically ill patients with AUD, AG was positively associated with 28-day inhospital mortality and 1-year mortality after adjusting confounders (

p
<
0.001

for all). Compared with lower AG (<12 mmol/L), patients in different groups (

12
≤
AG
<
14

mmol/L,

14
≤
AG
<
17

mmol/L,

17
≤
AG
<
20

mmol/L, and

AG
≥
20

mmol/L) had different HRs (95% CIs) for 28-day inhospital mortality (1.105, (0.906, 1.347); 1.171, (0.981, 1.398); 1.320, (1.108, 1.573); and 1.487, (1.254, 1.763), respectively) and 1-year mortality (1.037 (0.898, 1.196); 1.091 (0.955, 1.246); 1.201 (1.052, 1.371); and 1.3093 (1.149, 1.492), respectively). Conclusion. Increased AG is associated with greater 28-day inhospital mortality and 1-year mortality. The effect of AG on all-cause mortality is linear in critically ill AUD patients.
ALKBH5-Mediated m6A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer
Authors: Liu Hao , Lyu Hui , Jiang Guanmin , Chen Danyang , Ruan Sanbao , Liu Shuang , Zhou Lukun , Yang Minqiang , Zeng Shanshan , He Zhimin , Wang Hongsheng , Li Hongsheng , Zheng Guopei , Liu Bolin 
Published: September 2022

Abstract

Resistance to HER2-targeted therapy represents a significant challenge for the successful treatment of patients with breast cancer with HER2-positive tumors. Through a global mass spectrometry–based proteomics approach, we discovered that the expression of the N6-methyladenosine (m6A) demethylase ALKBH5 was significantly upregulated in HER2-targeted therapy-resistant breast cancer cells. Elevated expression of ALKBH5 was sufficient to confer resistance to HER2-targeted therapy, and specific knockdown of ALKBH5 rescued the efficacy of trastuzumab and lapatinib in resistant breast cancer cells. Mechanistically, ALKBH5 promoted m6A demethylation of GLUT4 mRNA and increased GLUT4 mRNA stability in a YTHDF2-dependent manner, resulting in enhanced glycolysis in resistant breast cancer cells. In breast cancer tissues obtained from patients with poor response to HER2-targeted therapy, increased expression of ALKBH5 or GLUT4 was observed and was significantly associated with poor prognosis in the patients. Moreover, suppression of GLUT4 via genetic knockdown or pharmacologic targeting with a specific inhibitor profoundly restored the response of resistant breast cancer cells to trastuzumab and lapatinib, both in vitro and in vivo. In conclusion, ALKBH5-mediated m6A demethylation of GLUT4 mRNA promotes resistance to HER2-targeted therapy, and targeting the ALKBH5/GLUT4 axis has therapeutic potential for treating patients with breast cancer refractory to HER2-targeted therapies.

Significance:
GLUT4 upregulation by ALKBH5-mediated m6A demethylation induces glycolysis and resistance to HER2-targeted therapy and represents a potential therapeutic target for treating HER2-positive breast cancer.
Abstract P005: Treatment And Clinical Implications Of Vascular Endothelial Growth Factor (VEGF) Inhibitor-induced Blood Pressure Rise: A Clinical Cohort Study
Authors: Van Dorst Daan C , Kabadayi Sumeyye , Oomen-de Hoop Esther , Danser Jan H , Mathijssen Ron , Versmissen Jorie 
Published: September 2022

Vascular endothelial growth factor inhibitors (VEGFI) are highly effective anti-cancer agents, but frequently induce a rise in blood pressure (BP). The optimal treatment of this BP rise is currently unknown, and risk factors for this rise and its association with survival remain unclear.
To this end, baseline characteristics and BP readings were collected from electronic medical records from oncology patients who received oral VEGFI treatment (sorafenib, sunitinib, pazopanib, regorafenib, lenvatinib or cabozantinib) in the period of 2008 until 2020. Risk factors for a clinically relevant BP rise, defined as an increase of ≥20mmHg in systolic BP (SBP) and/or ≥10mmHg in diastolic BP (DBP), were investigated via logistic regression, and their association with survival via Cox regression analysis.

In total, 343 patients were included of whom 162 (47%) developed a clinically relevant rise in BP ≥ 7 days after VEGFI treatment initiation. Both calcium channel blockers (CCB) and renin-angiotensin system inhibitors (RASI) effectively reduced SBP (-24.1mmHg and -18,2mmHg, respectively) and DBP (-12.0mmHg and -11mmHg, respectively) when started during VEGFI therapy. Pazopanib therapy (OR: 2.67, 95% CI 1.33-5.34,
P
=0.006, compared to sorafenib) and eGFR < 60ml/min/1.73m
2
(OR: 1.77, 95% CI 1.00-3.11,
P
=0.049) were risk factors for a BP rise, whereas a baseline BP of >140/90mmHg was associated with a lower risk (OR: 0.39, 95% CI 0.25-0.62,
P
<0.001). Only for renal cell carcinoma (RCC) patients, BP rise was associated with substantially improved overall survival (OS) compared to patients without BP rise (median OS 45.4 versus 20.3 months, respectively,
P
=0.003). No significant difference in OS between patients with and without new antihypertensives during VEGFI therapy was found (median OS 21.9 vs. 18.5 months, respectively,
P
= 0.143). In conclusion, the VEGFI-induced BP rise is determined by the type of VEGFI, baseline BP, and baseline eGFR. Both CCB and RASI can be used as effective antihypertensive treatment without impairing OS. Our study identified unique risk factors for a VEGFI-induced BP rise and demonstrated that this rise is an indication of treatment efficacy in RCC patients.
Abstract P091: Role Of Gata3 In Renin Cell Identity
Authors: Neyra Jesus S , Medrano Silvia , Sequeira Lopez Maria , Gomez Roberto A 
Published: September 2022

Renin cells act as precursors for other cell types in the kidney vasculature and show high plasticity in postnatal life in response to challenges to homeostasis. Our scRNA-seq studies revealed that the dual-zinc finger transcription factor (TF) Gata3, important for cell lineage commitment and differentiation in several tissues, is expressed in mouse renin cells under normal conditions and homeostatic threat. In addition, we found an enhancer associated with Gata3 in renin cells leading us to hypothesize that GATA3 is important for renin cell identity. We studied 60 and 76 day-old mice carrying a conditional deletion of Gata3 in renin cells: Gata3fl/fl;Ren1dCre/+ (Gata3 cKO), and control Gata3fl/fl;Ren1+/+ counterparts. Gata3 cKO mice exhibited increased BUN (43±4.6mg/dl) vs. control mice (BUN: 21±2mg/dl), suggestive of hypovolemia and/or compromised renal function. By immunostaining, renin expressing cells appeared very thin compared to the normal plump shape in control mice. Renin signal was abnormally localized to the Bowman’s capsule in some glomeruli, and there was an atypical strong Acta2 signal in the mesangium and Bowman’s capsule in Gata3 cKO mice. Distal tubules showed dilated morphology without visible intraluminal casts whereas proximal tubules appeared normal. Gata3 cKO recruited mice exhibited marked reductions in Ren1+ cells compared to controls by an 87% reduction of Ren1 mRNA levels by RT-qPCR (1.68 ± 0.11 vs 12.98 ± 0.98, p=0.0006). H&E, PAS, and Mason’s Trichrome reactions demonstrated increased glomerular fusion, absent cubical epithelial cells in Bowman’s capsule, and intraglomerular aneurysms.
In summary, we found abnormal expression and localization of Ren1 and Acta2 and abnormal morphology of kidneys in Gata3 cKO mice. Our results suggest a role of Gata3 in the identity of cells of the renin lineage. Future studies will investigate the role of Gata3 during development and in older animals.