bluuebunny/crossref_metadata_2025_split huggingface dataset:
Missing Bullets: Bullet Embolization Case Series and Review of the Literature
Authors: Castater Christine , Noorbakhsh Soroosh , Harousseau William , Klingensmith Nathan , Koganti Deepika , Nguyen Jonathan , Smith Randi N. , Benarroch-Gampel Jaime , Ramos Christopher R. , Rajani Ravi , Sciarretta Jason D. 
Published: November 2022

Purpose Bullet embolization is a rare but dangerous phenomenon. Based on the location of embolization, migration of bullets can cause limb or intra-abdominal ischemia, pulmonary infarction, cardiac valve injury, or cerebrovascular accident. Bullet emboli can present a diagnostic challenge given the varied nature of complications based on location of embolization, which may not coincide with the site of initial injury. The purpose of this study is to present several cases of bullet embolization from our busy urban trauma center and make recommendations for management. Methods We present 3 cases of bullet embolization seen in injured patients at our Level 1 trauma center. We describe our management of these injuries and make recommendations for management in the context of our institutional experience and comment on the available literature regarding bullet embolization. Results Two of our patients presented in extremis and required operative intervention to achieve stability. The intravascular missile was discovered intraoperatively in one patient and removed in the operating room, while the missile was discovered on postoperative imaging in another patient and again removed operatively after an unsuccessful attempt at minimally invasive retrieval. Our third patient remained hemodynamically stable throughout his hospitalization and had endovascular management of his bullet embolus. Conclusion Bullet emboli present a challenging complication of penetrating trauma. We recommend removal of all arterial bullet emboli and those within the pulmonary venous system. In hemodynamically stable patients, we recommend initial attempts of endovascular retrieval followed by open surgical removal. We recommend open removal in cases of hemodynamic instability.
Sports Participation After Reverse Total Shoulder Replacement
Authors: Al Housni Hilal S.A. , Lam Patrick H. , Latif Joseph W. , Murrell George A.C. 
Published: November 2022

Background: Reverse total shoulder replacement (RTSR) is becoming a popular and reliable treatment for rotator cuff arthropathy. However, little is known about the ability to participate in sports after surgery. Purpose: To determine to what extent RTSR will allow patients to participate in sporting activities and identify the associated factors that could affect postoperative sports participation. Study Design: Case series; Level of evidence, 4. Methods: Data were collected prospectively from patients who underwent RTSR over a 10-year period from April 2009 to May 2019. Patients were assessed before surgery, at 6 months after surgery, and at the final follow-up. Patients were asked within a validated shoulder questionnaire to rank their current highest level of sports participation, overall shoulder status, frequency of pain, level of pain, and functional levels. Their shoulder range of motion and strength were assessed before surgery and at 6 months after surgery. Results: The study included 108 shoulders (106 patients). The mean age was 74 years (range, 51-88 years), with 44 men and 64 women. The mean follow-up was 4 years. Overall shoulder satisfaction, frequency and levels of pain, and shoulder function improved significantly at 6 months and 4 years ( P < .0001). External rotation, abduction, and forward flexion range of motion improved significantly at 6 months ( P < .05 for all). The strength of internal rotation, external rotation, abduction, and adduction improved significantly at 6 months ( P < .001 for all). The rate of return to sports was 67% at 6 months and 48% at 4 years. Multiple significantly associated factors were identified with return to sports at 6 months, including sex and age. Conclusion: The rate of return to sports after RTSR is high. Around two-thirds of patients can return to sports at 6 months postoperatively, although the results slightly deteriorate over time (48% at 4 years).
Postnatal Care Utilization Coverage and its Associated Factors Among Mothers in South Gondar Zone, Northwest Ethiopia: A Cross-Sectional Study
Authors: Fenta Setegn Muche , Moyehodie Yikeber Abebaw , Belay Alebachew Taye , Biresaw Hailegebrael Birhan , Fentaw Kenaw Derebe , Yalew Mequanint Melkam , Muluneh Mitiku Wale , Mulugeta Solomon Sisay , Mekie Maru 
Published: November 2022

Background Postnatal care (PNC) is critical for both the mother and the infant to treat delivery complications and provide the mother with important information on caring for herself and her baby. However, only 17% of women and 13% of newborns in Ethiopia received a postnatal checkup within the first two days of birth. This figure is significantly lower than the least developed countries. This study aimed to assess the coverage and associated factors of PNC service utilization in South Gondar Zone, Northwest Ethiopia. Method A community-based cross-sectional study was conducted from September 2020 to May 2021. The data were gathered using an interviewer-administered structured questionnaire. A total of 434 women who gave birth within 2 years of the study were included in the analysis. Bivariable and multivariable logistic regression model was used to identify factors associated with PNC service utilization. Result The prevalence of women who used PNC services was 36.4%. The study showed that antenatal care visit, husbands who have a secondary education, women with a secondary education, daily laborer women, husbands working for the government or non-profit sector, delivered in a health institution, nearby hospitals, travel by car to the nearest health facility were positively associated with PNC utilization. While, not having a cell phone, rural women and not having road access to a health facility, have not been receiving counseling were negatively associated with PNC utilization. Conclusion The coverage of PNC service utilization in the study area was extremely low. Therefore, government and health care departments should pay special attention to uneducated women, women in rural areas, and women who are unemployed, are not exposed to mass media, and do not have access to transportation to improve PNC service utilization. Furthermore, programs educating mothers on the benefits of antenatal checkups and safer places of childbirth should be considered to increase PNC service utilization.
New arsenate minerals from the Arsenatnaya fumarole, Tolbachik volcano, Kamchatka, Russia. XIX. Axelite, Na14Cu7(AsO4)8F2Cl2
Authors: Pekov Igor V. , Zubkova Natalia V. , Agakhanov Atali A. , Yapaskurt Vasiliy O. , Belakovskiy Dmitry I. , Britvin Sergey N. , Sidorov Evgeny G. , Kutyrev Anton V. , Pushcharovsky Dmitry Yu. 
Published: November 2022

AbstractThe new mineral axelite, ideally Na14Cu7(AsO4)8F2Cl2, was found in the Arsenatnaya fumarole at the Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka, Russia. It is associated with sylvite, halite, arsmirandite, bradaczekite, johillerite, tilasite, ericlaxmanite, lammerite, hematite, tenorite, cassiterite, pseudobrookite, aphthitalite-group sulfates, anhydrite, fluoborite, sanidine and fluorophlogopite. Axelite occurs as tabular, quadratic, rectangular or stronger distorted crystals up to 0.02 × 0.1 × 0.1 mm, sometimes combined in interrupted crusts up to 0.4 mm across overgrowing sylvite. It is transparent, sky-blue, with vitreous lustre. Cleavage was not observed. Dcalc is 3.662 g cm–3. Axelite is optically uniaxial (–), ɛ = 1.650(4) and ω = 1.678(4). Chemical composition (wt.%, electron microprobe data) is: Na2O 22.54, K2O 0.08, CaO 0.04, MgO 0.05, CuO 26.69, P2O5 1.75, V2O5 0.15, As2O5 44.14, SO3 0.04, F 1.57, Cl 3.60, –O=(F,Cl) –1.47, total 99.18. The empirical formula based on O+F+Cl=36 apfu is Na14.37K0.03Ca0.01Mg0.02Cu6.63P0.49V0.03As7.59S0.01O32.36F1.63Cl2.01. Axelite is tetragonal, P4bm, a = 14.5957(2), c = 8.34370(18) Å, V = 1777.51(6) Å3 and Z = 2. The strongest reflections of the powder X-ray diffraction (XRD) pattern [d,Å(I)(hkl)] are: 8.32(44)(001), 5.156(47)(220), 4.168(21)(002), 3.246(34)(222), 3.180(61)(331), 2.747(100)(402), 2.709(36)(511) and 2.580(29)(440). The crystal structure, solved from single-crystal XRD data (R = 4.50%), is unique. It is based on the heteropolyhedral chains built by clusters formed by CuO4Cl square pyramids connected with AsO4 tetrahedra. Adjacent chains are connected via common vertices of AsO4 tetrahedra with CuO4Cl pyramids to form a heteropolyhedral pseudo-framework. Axelite is remotely related, in both structural and chemical aspects, to lavendulan-like minerals and synthetic compounds. The mineral is named in honour of the outstanding Finnish–Russian crystallographer, mineralogist and material scientist Axel Gadolin (1828–1892).
Open-label pilot study of romiplostim for thrombocytopenia after autologous hematopoietic cell transplantation
Authors: Scordo Michael , Gilbert Leah J. , Hanley Danielle M. , Flynn Jessica R. , Devlin Sean M. , Nguyen Linh K. , Ruiz Josel D. , Shah Gunjan L. , Sauter Craig S. , Chung David J. , Landau Heather J. , Lahoud Oscar B. , Lin Richard J. , Dahi Parastoo B. , Perales Miguel-Angel , Giralt Sergio A. , Soff Gerald A. 
Published: November 2022

Abstract
There are no standard treatments to prevent or hasten the recovery from severe conditioning-regimen–induced thrombocytopenia occurring after autologous hematopoietic cell transplantation (auto-HCT). We conducted an open-label, single-arm pilot study of romiplostim, a thrombopoietin receptor agonist, to enhance platelet recovery in patients with multiple myeloma or lymphoma undergoing auto-HCT. All patients were treated weekly with romiplostim starting day +1 after auto-HCT until the platelet count was &gt;50 × 109/L without transfusion. Compared with contemporary retrospective data from romiplostim-naïve patients (N = 853), romiplostim-treated patients (N = 59) had a similar median number of days of grade 4 thrombocytopenia or days requiring transfusions, time to platelet engraftment, and number of platelets transfusions during the auto-HCT. However, romiplostim-treated patients had enhanced platelet recovery to normal values beginning at approximately day +15. In matched cohort multivariable analyses, romiplostim treatment was associated with higher platelet counts by an average of 40 × 109/L (95% confidence interval (CI) (14, 67), P = .003) and 118 × 109/L (95% CI [84, 152], P&lt;.001) at days +21 and +30, respectively, compared with those of no romiplostim. Only 1 adverse event was deemed possibly attributable to romiplostim: a low-risk pulmonary embolism in a patient with multiple myeloma. In conclusion, romiplostim showed promising activity and safety after auto-HCT, but the improvement in platelet counts occurred later than the goal of shortening the duration and depth of the platelet nadir. This trial was registered at www.clinicaltrials.gov (#NCT04478123).
Peripheral blood monocyte count is a dynamic prognostic biomarker in multiple myeloma
Authors: Edwards Camille V. , Hassan Hamza , Yildirim Cenk , Ferri Grace , Verma Karina P. , Murray Horwitz Mara E. , Fillmore Nathanael R. , Munshi Nikhil C. 
Published: November 2022

Abstract
With the growing knowledge of multiple myeloma (MM) pathobiology and the introduction of novel therapies, risk stratification continues to evolve. Myeloid-derived suppressor cells and tumor-associated macrophages, derived from peripheral blood monocytes, support malignant plasma cell proliferation in the bone marrow. Because peripheral blood absolute monocyte count (AMC) is thought to reflect the bone marrow microenvironment, we sought to evaluate the prognostic significance of AMC in MM. We retrospectively analyzed 10 822 patients newly diagnosed with MM between 2000 and 2019 at Veteran’s Administration hospitals. We obtained AMC closest to diagnosis and every 3 months thereafter up to 2.5 years. Patients were stratified into 4 groups: low, normal, elevated, and severely elevated AMC (&lt;0.2, 0.2-&lt;0.8, 0.8-&lt;1.25, and ≥1.25 × 103/mm3, respectively). Abnormal AMC at diagnosis was observed in 25.3% of the patients and was associated with an inferior overall survival (OS). In patients with low, severely elevated, elevated, and normal AMC, respectively, median OS at diagnosis was 2.3, 2.7, 3.1, and 3.6 years (P &lt; .001) and at 2.5 years was 2.0, 2.6, 3.4, and 3.9 years (P &lt; .001). Patients with normal AMC at diagnosis who developed an abnormal AMC &gt;1 year after diagnosis also had an inferior OS relative to patients who maintained a normal AMC. Abnormal AMC was also associated with inferior OS independent of validated prognostic markers, including the international staging system and lactate dehydrogenase. Our findings provide novel clues for future prospective studies on the functional role of monocytes in MM, which could be a readily available metric for risk stratification.
Fabrication of Ordered Micro/Nanostructures Using Probe-Based Force-Controlled Micromachining System
Authors: Geng Yanquan , Wang Yuzhang , Cai Jianxiong , Zhang Jingran , Yan Yongda 
Published: November 2022

AbstractThis paper presents a probe-based force-controlled nanoindentation method to fabricate ordered micro/nanostructures. Both the experimental and finite element simulation approaches are employed to investigate the influence of the interval between the adjacent indentations and the rotation angle of the probe on the formed micro/nanostructures. The non-contacting part between indenter and the sample material and the height of the material pile-up are two competing factors to determine the depth relationship between the adjacent indentations. For the one array indentations, nanostructures with good depth consistency and periodicity can be formed after the depth of the indentation becoming stable, and the variation of the rotation angle results in the large difference between the morphology of the formed nanostructures at the bottom of the one array indentation. In addition, for the indentation arrays, the nanostructures with good consistency and periodicity of the shape and depth can be generated with the spacing greater than 1 μm. Finally, Raman tests are also carried out based on the obtained ordered micro/nanostructures with Rhodamine probe molecule. The indentation arrays with a smaller spacing lead to better the enhancement effect of the substrate, which has the potential applications in the fields of biological or chemical molecular detection.
Fuel and material utilization of a waste shiitake (Lentinula edodes) mushroom bed derived from hardwood chips II thermal conductivity of compression-dried waste mushroom beds
Authors: Jiang Zhuoqiu , Sekino Noboru 
Published: November 2022

AbstractThis study investigated using waste mushroom beds as insulation material and applied compression-drying to eliminate the coarse voids that are unfavorable for insulation. The relationship between air-dry density and thermal conductivity was investigated. The mean air-dry density of the uncompacted waste mushroom beds was approximately 200 kg/m3, which increased to approximately 550 kg/m3 after four levels of compression-drying. A linear relationship was recognized between the air-dry density and thermal conductivity of the waste mushroom bed. Comparing this relationship to those of wood and mat-formed wood-based panels showed that the thermal conductivity of a waste mushroom bed is similar to that of wood at low densities and mat-formed wood-based panels at high densities. Furthermore, the thermal conductivity of heat bridges was estimated using a series–parallel heat-flow model for voids and substances, and the substance thermal conductivity was in the order of wood (0.218 W/mK), waste mushroom bed (0.288 W/mK), and mycelium (0.368 W/mK). The same heat-flow model was applied to a waste mushroom bed to obtain the substance thermal conductivity along the heat-flow direction. The results show that the waste mushroom bed substance also has an anisotropic thermal conductivity.
An Enzyme-Free Sandwich Amperometry-Type Immunosensor Based on Au/Pt Nanoparticle-Functionalized Graphene for the Rapid Detection of Avian Influenza Virus H9 Subtype
Authors: Huang Jiaoling , Xie Zhixun , Li Meng , Luo Sisi , Deng Xianwen , Xie Liji , Fan Qing , Zeng Tingting , Zhang Yanfang , Zhang Minxiu , Wang Sheng , Xie Zhiqin , Li Dan 
Published: November 2022

AbstractAvian influenza virus H9 subtype (AIV H9) has contributed to enormous economic losses. Effective diagnosis is key to controlling the spread of AIV H9. In this study, a nonenzymatic highly electrocatalytic material was prepared using chitosan (Chi)-modified graphene sheet (GS)-functionalized Au/Pt nanoparticles (GS-Chi-Au/Pt), followed by the construction of a novel enzyme-free sandwich electrochemical immunosensor for the detection of AIV H9 using GS-Chi-Au/Pt and graphene–chitosan (GS-Chi) nanocomposites as a nonenzymatic highly electrocatalytic material and a substrate material to immobilize capture antibodies (avian influenza virus H9-monoclonal antibody, AIV H9/MAb), respectively. GS, which has a large specific surface area and many accessible active sites, permitted multiple Au/Pt nanoparticles to be attached to its surface, resulting in substantially improved conductivity and catalytic ability. Au/Pt nanoparticles can provide modified active sites for avian influenza virus H9-polyclonal antibody (AIV H9/PAb) immobilization as signal labels. Upon establishing the electrocatalytic activity of Au/Pt nanoparticles on graphene towards hydrogen peroxide (H2O2) reduction for signal amplification and optimizing the experimental parameters, we developed an AIV H9 electrochemical immunosensor, which showed a wide linear range from 101.37 EID50 mL−1 to 106.37 EID50 mL−1 and a detection limit of 100.82 EID50 mL−1. This sandwich electrochemical immunosensor also exhibited high selectivity, reproducibility and stability.
Identification of crucial genes and metabolites regulating the eggshell brownness in chicken
Authors: Yang Jing , Mao Zhiqiong , Wang Xiqiong , Zhuang Jingjie , Gong Sijia , Gao Zhouyang , Xu Guiyun , Yang Ning , Sun Congjiao 
Published: November 2022

Abstract
Background
Protoporphyrin IX (Pp IX) is the primary pigment for brown eggshells. However, the regulatory mechanisms directing Pp IX synthesis, transport, and genetic regulation during eggshell calcification in chickens remain obscure. In this study, we investigated the mechanism of brown eggshell formation at different times following oviposition, using White Leghorn hens (WS group), Rhode Island Red light brown eggshell line hens (LBS group) and Rhode Island Red dark brown eggshell line hens (DBS group).

Results
At 4, 16 and 22 h following oviposition, Pp IX concentrations in LBS and DBS groups were significantly higher in shell glands than in liver (P < 0.05). Pp IX concentrations in shell glands of LBS and DBS groups at 16 and 22 h following oviposition were significantly higher than WS group (P < 0.05). In comparative transcriptome analysis, δ-aminolevulinate synthase 1 (ALAS1), solute carrier family 25 member 38 (SLC25A38), ATP binding cassette subfamily G member 2 (ABCG2) and feline leukemia virus subgroup C cellular receptor 1 (FLVCR1), which were associated with Pp IX synthesis, were identified as differentially expressed genes (DEGs). RT-qPCR results showed that the expression level of ALAS1 in shell glands was significantly higher in DBS group than in WS group at 16 and 22 h following oviposition (P < 0.05). In addition, four single nucleotide polymorphisms (SNPs) in ALAS1 gene that were significantly associated with eggshell brownness were identified. By identifying the differential metabolites in LBS and DBS groups, we found 11-hydroxy-E4-neuroprostane in shell glands and 15-dehydro-prostaglandin E1(1-) and prostaglandin G2 2-glyceryl ester in uterine fluid were related to eggshell pigment secretion.

Conclusions
In this study, the regulatory mechanisms of eggshell brownness were studied comprehensively by different eggshell color and time following oviposition. Results show that Pp IX is synthesized de novo and stored in shell gland, and ALAS1 is a key gene regulating Pp IX synthesis in the shell gland. We found three transporters in Pp IX pathway and three metabolites in shell glands and uterine fluid that may influence eggshell browning.
Patient and hospital characteristics predict prolonged emergency department length of stay and in-hospital mortality: a nationwide analysis in Korea
Authors: Lee Kyung-Shin , Min Hye Sook , Moon Jae Young , Lim Daesung , Kim Younghwan , Ko Eunsil , Kim You Sun , Kim Joohae , Lee Jeehye , Sung Ho Kyung 
Published: November 2022

AbstractBackgroundProlonged emergency department length of stay (EDLOS) in critically ill patients leads to increased mortality. This nationwide study investigated patient and hospital characteristics associated with prolonged EDLOS and in-hospital mortality in adult patients admitted from the emergency department (ED) to the intensive care unit (ICU).MethodsWe conducted a retrospective cohort study using data from the National Emergency Department Information System. Prolonged EDLOS was defined as an EDLOS of ≥ 6 h. We constructed multivariate logistic regression models of patient and hospital variables as predictors of prolonged EDLOS and in-hospital mortality.ResultsBetween 2016 and 2019, 657,622 adult patients were admitted to the ICU from the ED, representing 2.4% of all ED presentations. The median EDLOS of the overall study population was 3.3 h (interquartile range, 1.9–6.1 h) and 25.3% of patients had a prolonged EDLOS. Patient characteristics associated with prolonged EDLOS included night-time ED presentation and Charlson comorbidity index (CCI) score of 1 or higher. Hospital characteristics associated with prolonged EDLOS included a greater number of staffed beds and a higher ED level. Prolonged EDLOS was associated with in-hospital mortality after adjustment for selected confounders (adjusted odds ratio: 1.18, 95% confidence interval: 1.16–1.20). Patient characteristics associated with in-hospital mortality included age ≥ 65 years, transferred-in, artificially ventilated in the ED, assignment of initial triage to more urgency, and CCI score of 1 or higher. Hospital characteristics associated with in-hospital mortality included a lesser number of staffed beds and a lower ED level.ConclusionsIn this nationwide study, 25.3% of adult patients admitted to the ICU from the ED had a prolonged EDLOS, which in turn was significantly associated with an increased in-hospital mortality risk. Hospital characteristics, including the number of staffed beds and the ED level, were associated with prolonged EDLOS and in-hospital mortality.