bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of host factor with virological response to direct-acting antiviral treatment in hepatitis C patients
Authors: Rusman Resha Dermawansyah , Daud Nu’man AS , Parewangi Muhammad Luthfi , Bakri Syakib , Aman Andi Makbul , Rasyid Haerani , Seweng Arifin , Tahir Akiko Syawalidhany 
Published: September 2022

Abstract
Background
Hepatitis C virus (HCV) infection is the global epidemic of this century, affecting almost 100 million people, and it is now the leading cause of liver-related mortality and liver transplantation. Interferon (IFN)-α was introduced as the first treatment for chronic hepatitis C but had several limitations, including factors that cause unresponsiveness to therapy, such as viral and host factors. The availability of non-interferon antiviral agents, direct-acting antivirals (DAAs), has led to a major paradigm shift in the treatment of HCV infection. This therapy has been shown to achieve higher cure rates and minimal side effect profiles in clinical trials. This study is aimed to determine the correlation between host factors, such as age, gender, and body mass index (BMI) with virological response to DAA treatment in hepatitis C patients.

Result
Observational research with a retrospective cohort approach was conducted at Wahidin Sudirohusodo Hospital, Makassar, Indonesia, from April 2021 to October 2021. The virological response was assessed using HCV-RNA quantitative and sustained virological response (SVR) 12 weeks after therapy. The research was conducted on 86 subjects consisting of 57 men and 29 women with a mean age of 48.69±13.94 years and mean BMI of 23.17±3.71 kg/m2, with SVR12 up to 90.7%. Study analysis did not find a significant correlation between age, gender, and BMI, with virological response SVR12 of chronic hepatitis C patients with direct-acting antiviral (p>0.05).

Conclusion
Age, gender, and body mass index do not influence the success of DAA therapy.
Language profile in different kinds of apraxia in post-stroke patients
Authors: Sheikhany Ayaatallah R. , Othman Dalia M. , Elshebl Omnia Z. , Abdelhady Aisha F. 
Published: September 2022

AbstractBackgroundStroke affects all aspects of communication of patients by causing disorders of motor control (dysarthria or apraxia) or language (dysphasia) or both. The aim of this study is to evaluate language skills in patients post-stroke presented with comorbidity with different types of apraxia.MethodsAn analytical cross-sectional study was carried out, and a number of 58 stroke adults with comorbid apraxic manifestations of various types were included after assessing them using the protocol of motor programming skills that was extracted from thesis titled “Assessment protocol of motor programming skills after cerebrovascular insults” from October 2016 to July 2018. They were subjected to the interview and personal history taking, and a modified comprehensive aphasia test to determine their language profile.ResultsPatients with verbal apraxia showed difficulty with tasks tapping verbal fluency, repetition, and picture description. The language deficits in ideational apraxia patients included cognition tasks, verbal fluency, sentence comprehension, and naming. Constructional apraxia patients showed language deficits in word comprehension, complex word repetition, and naming. Limb apraxia showed greater deficits on tasks tapping working memory and processing speed while buccofacial apraxia was accompanied by fewer language deficits in reading and repeating complex words.ConclusionHeterogeneous language profile was found in different types of apraxia.
Seismic performance of cable-stayed bridges with different geometric conditions
Authors: Fawzy Ahmed M. , El-Kashif Khaled F. , Abdalla Hany A. 
Published: September 2022

AbstractCable-stayed bridges have gained greater coverage in the last few decades. This study focuses mainly on two parameters. Firstly, the shape of pylons; the performance of many shapes is investigated after being exposed to an earthquake. Secondly, the effect of changing deck width of an inverted Y-shaped pylon with variation in main span length. The numerical study was performed using MIDAS civil software. It was concluded that the most efficient pylon shape in terms of seismic performance was that of pyramid shape followed by a delta shape. In addition, it was found that changing deck width for the same main span gives a negligible difference to normalized shear force.
Revolution qua Restoration
Authors: Tomba Massimiliano 
Published: September 2022

Abstract
Revolution and restoration are usually understood as opposite terms. This article aims to disarticulate this binary. Suppose the modern concept of revolution can be defined as a project of social reorganization led by the state or by a constituent power that aims to become the state. In that case, the restoration is a defense of society, institutions, traditions, and customs from the state. However, restoration is also an expression of a different political orientation of the revolutionary trajectory. The temporality of revolution is mainly future oriented, whereas the restorative temporality implies continuity, the reactivation of institutions from the past, and their experimentation in everyday life. These two temporal dimensions are intertwined. They can either combine in new political configurations or oppose each other in progress and regress, forward and backward. This article examines the Zapatista insurgency in Chiapas as an example that combines the two temporal dimensions.
Intracranial Artery Morphology in Pediatric Moya Moya Disease and Moya Moya Syndrome
Authors: Yedavalli Vivek S. , Quon Jennifer L. , Tong Elizabeth , van Staalduinen Eric K. , Mouches Pauline , Kim Lily H. , Steinberg Gary K. , Grant Gerald A. , Yeom Kristen W. , Forkert Nils D. 
Published: September 2022

BACKGROUND:
Moya Moya disease (MMD) and Moya Moya syndrome (MMS) are cerebrovascular disorders, which affect the internal carotid arteries (ICAs). Diagnosis and surveillance of MMD/MMS in children mostly rely on qualitative evaluation of vascular imaging, especially MR angiography (MRA).

OBJECTIVE:
To quantitatively characterize arterial differences in pediatric patients with MMD/MMS compared with normal controls.

METHODS:
MRA data sets from 17 presurgery MMD/MMS (10M/7F, mean age = 10.0 years) patients were retrospectively collected and compared with MRA data sets of 98 children with normal vessel morphology (49 male patients; mean age = 10.6 years). Using a level set segmentation method with anisotropic energy weights, the cerebral arteries were automatically extracted and used to compute the radius of the ICA, middle cerebral artery (MCA), anterior cerebral artery (ACA), posterior cerebral artery (PCA), and basilar artery (BA). Moreover, the density and the average radius of all arteries in the MCA, ACA, and PCA flow territories were quantified.

RESULTS:
Statistical analysis revealed significant differences comparing children with MMD/MMS and those with normal vasculature (P < .001), whereas post hoc analyses identified significantly smaller radii of the ICA, MCA-M1, MCA-M2, and ACA (P < .001) in the MMD/MMS group. No significant differences were found for the radii of the PCA and BA or any artery density and average artery radius measurement in the flow territories (P > .05).

CONCLUSION:
His study describes the results of an automatic approach for quantitative characterization of the cerebrovascular system in patients with MMD/MMS with promising preliminary results for quantitative surveillance in pediatric MMD/MMS management.
Impact of BRCA Mutation Status on Tumor Dissemination Pattern, Surgical Outcome and Patient Survival in Primary and Recurrent High-Grade Serous Ovarian Cancer: A Multicenter Retrospective Study by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium
Authors: Glajzer Jacek , Castillo-Tong Dan Cacsire , Richter Rolf , Vergote Ignace , Kulbe Hagen , Vanderstichele Adriaan , Ruscito Ilary , Trillsch Fabian , Mustea Alexander , Kreuzinger Caroline , Gourley Charlie , Gabra Hani , Taube Eliane T. , Dorigo Oliver , Horst David , Keunecke Carlotta , Baum Joanna , Angelotti Timothy , Sehouli Jalid , Braicu Elena Ioana 
Published: September 2022

Abstract
Background
This study seeks to evaluate the impact of breast cancer (BRCA) gene status on tumor dissemination pattern, surgical outcome and survival in a multicenter cohort of paired primary ovarian cancer (pOC) and recurrent ovarian cancer (rOC).

Patients and Methods
Medical records and follow-up data from 190 patients were gathered retrospectively. All patients had surgery at pOC and at least one further rOC surgery at four European high-volume centers. Patients were divided into one cohort with confirmed mutation for BRCA1 and/or BRCA2 (BRCAmut) and a second cohort with BRCA wild type or unknown (BRCAwt). Patterns of tumor presentation, surgical outcome and survival data were analyzed between the two groups.

Results
Patients with BRCAmut disease were on average 4 years younger and had significantly more tumor involvement upon diagnosis. Patients with BRCAmut disease showed higher debulking rates at all stages. Multivariate analysis showed that only patient age had significant predictive value for complete tumor resection in pOC. At rOC, however, only BRCAmut status significantly correlated with optimal debulking. Patients with BRCAmut disease showed significantly prolonged overall survival (OS) by 24.3 months. Progression-free survival (PFS) was prolonged in the BRCAmut group at all stages as well, reaching statistical significance during recurrence.

Conclusions
Patients with BRCAmut disease showed a more aggressive course of disease with earlier onset and more extensive tumor dissemination at pOC. However, surgical outcome and OS were significantly better in patients with BRCAmut disease compared with patients with BRCAwt disease. We therefore propose to consider BRCAmut status in regard to patient selection for cytoreductive surgery, especially in rOC.
Expanding our concept of simulation in radiology: a “Radiology Requesting” session for undergraduate medical students
Authors: Hartley James , Agrawal Bobby , Narang Karamveer , Kelliher Edel , Lunn Elizabeth , Bhudia Roshni 
Published: September 2022

Objectives: Whilst radiology is central to the modern practice of medicine, graduating doctors often feel unprepared for radiology in practice. Traditional radiological education focuses on image interpretation. Key areas which are undertaught include communication skills relating to the radiology department. We sought to design teaching to fill this important gap. Methods: We developed a small group session using in situ simulation to enable final and penultimate year medical students to develop radiology-related communication and reasoning skills. Students were given realistic cases, and then challenged to gather further information and decide on appropriate radiology before having the opportunity to call a consultant radiologist on a hospital phone and simulate requesting the appropriate imaging with high fidelity. We evaluated the impact of the teaching through before-and-after Likert scales asking students about their confidence with various aspects of requesting imaging, and qualitatively through open-ended short answer questionnaires. Results: The session was delivered to 99 students over 24 sessions. Self-reported confidence in discussing imaging increased from an average of 1.7/5 to 3.4/5 as a result of the teaching (p < 0.001) and students perceived that they had developed key skills in identifying and communicating relevant information. Conclusions: The success of this innovative session suggests that it could form a key part of future undergraduate radiology education, and that the method could be applied in other areas to broaden the application of simulation. Advances in knowledge: This study highlights a gap in undergraduate medical education. It describes and demonstrates the effectiveness of an intervention to fill this gap.
Osgood-Schlatter disease and potential treatment
Authors: Wojcik Bartlomiej , Fabis Mateusz , Remjasz Klaudia , Kuchnicka Julia , Zadrożna Karolina , Aleksandrowicz Jakub , Siedlecki Wojciech 
Published: September 2022

Background: Aseptic necrosis of the tibial tuberosity, also known as Osgood-Schlatter disease, is one of the more common causes of pain in the tibia area in children and adolescents. The pathology is much more common in boys than in girls. Young athletes, including training footballers, basketball players and volleyball players, as well as children who actively spend their free time are particularly exposed to the development of the disease.
Material and methods: This paper was based on medical articles collected in PubMed , medical websites and books. The research has been done by looking through key words such as:’’ Osgood-Schlatter disease”,’’Osgood-Schlatter treatment”
Results: Osgood-Schlatter disease is usually self-limiting. In the absence of symptom relief, there are operational methods, which, however, are ambiguous.
Conclusions: Treatment of OSD patients and a challenge for healthcare professionals.
Diagnostic ability of a computer algorithm to identify prehospital STEMI
Authors: Funder Jordan L , Bowles Kelly-Ann , Ross Linda J 
Published: September 2022

Background: Acute myocardial infarction (AMI) accounts for 43% of deaths related to ischaemic heart disease, with ST-segment elevation myocardial infarction (STEMI) accounting for 25%–40% of all AMI presentations. Given the impact of these diseases, there is a strong prehospital focus on early identification, treatment and transport of patients with acute coronary syndrome. The main aim of the STEMI system of care is to reduce the time to reperfusion of the myocardium, thereby improving morbidity and mortality rates. Therefore, the identification of STEMI by paramedics can have a dramatic effect on patients' long-term health outcomes. Ambulance Victoria paramedics play a crucial role in the care provided to AMI patients across the state, with the assistance of a computer-automated interpretation of 12-lead electrocardiograms (ECGs) to aid STEMI identification. Objectives: This study's objective is to analyse the diagnostic capability of the computer-automated interpretation to diagnose STEMI in the out-of-hospital setting. Methods: Quantitative data from January 2018 to December 2019 was sourced from the Victorian Ambulance STEMI Quality Initiative. These data were periodically matched with hospital outcome and diagnosis data from the Victorian Cardiac Outcomes Registry to compare provisional paramedic diagnoses with the final hospital diagnoses. Results: Of the 5269 cases of suspected STEMI, 765 (14.5%) could be matched with outcome data. Of these 765 cases, 88.9% were correctly identified as STEMI. The remaining 10% were categorised as either non-STEMI or unstable angina. No data were available for 1.1%. Conclusions: The diagnostic capability of the Zoll Inovise 12L interpretive algorithm to diagnose STEMI in the out-of-hospital setting appears safe and feasible. However, because of limited data matching paramedic findings with patient outcomes in hospital, no hard conclusions can be drawn. Furthermore, there is no way to ascertain how many false positives the Zoll monitor is interpreting. Further investigation is required to assess the true diagnostic capability of the Zoll Inovise 12L interpretive algorithm.
TMExplorer: A tumour microenvironment single-cell RNAseq database and search tool
Authors: Christensen Erik , Naidas Alaine , Chen David , Husic Mia , Shooshtari Parisa 
Published: September 2022

Motivation
The tumour microenvironment (TME) contains various cells including stromal fibroblasts, immune and malignant cells, and its composition can be elucidated using single-cell RNA sequencing (scRNA-seq). scRNA-seq datasets from several cancer types are available, yet we lack a comprehensive database to collect and present related TME data in an easily accessible format.

Results
We therefore built a TME scRNA-seq database, and created the R package TMExplorer to facilitate investigation of the TME. TMExplorer provides an interface to easily access all available datasets and their metadata. The users can search for datasets using a thorough range of characteristics. The TMExplorer allows for examination of the TME using scRNA-seq in a way that is streamlined and allows for easy integration into already existing scRNA-seq analysis pipelines.
Procalcitonin as a predictive marker in COVID-19: A systematic review and meta-analysis
Authors: Kumar Amit , Karn Era , Trivedi Kiran , Kumar Pramod , Chauhan Ganesh , Kumari Aradhana , Pant Pragya , Munisamy Murali , Prakash Jay , Sarkar Prattay Guha , Prasad Kameshwar , Prasad Anupa 
Published: September 2022

BackgroundCoronavirus disease 2019 has emerged as a global pandemic causing millions of critical cases and deaths. Early identification of at-risk patients is crucial for planning triage and treatment strategies.Methods and findingsWe performed this systematic review and meta-analysis to determine the pooled prognostic significance of procalcitonin in predicting mortality and severity in patients with COVID-19 using a robust methodology and clear clinical implications.DesignWe used Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Cochrane Handbook for Systematic Reviews of Interventions guidelines. We included thirty-two prospective and retrospective cohort studies involving 13,154 patients.ResultsThe diagnostic odds ratio of procalcitonin for predicting mortality were estimated to be 11 (95% CI: 7 to 17) with sensitivity, specificity, and summary area under the curveof 0.83 (95% CI: 0.70 to 0.91), 0.69 (95% CI: 0.58 to 0.79), and 0.83 (95% CI: 0.79 to 0.86) respectively. While for identifying severe cases of COVID-19, the odds ratio was 8.0 (95% CI 5.0 to 12.0) with sensitivity, specificity, and summary area under the curve of 0.73 (95% CI 0.67 to 0.78), 0.74 (0.66 to 0.81), and 0.78 (95% CI 0.74 to 0.82) respectively.ConclusionProcalcitonin has good discriminatory power for predicting mortality and disease severity in COVID-19 patients. Therefore, procalcitonin measurement may help identify potentially severe cases and thus decrease mortality by offering early aggressive treatment.
COVID-19 symptom relationship to antibody response and ACE2 neutralization in recovered health systems employees before and after mRNA BNT162b2 COVID-19 vaccine
Authors: Huhn Gregory , Poorbaugh Josh , Zhang Lin , Beasley Stephanie , Nirula Ajay , Brothers Jennifer , Welbel Sharon , Wilson James , Gillani Sheena , Weber Kathleen M. , Morack Ralph , Keckler Kody , Benschop Robert J. 
Published: September 2022

Background
The humoral response to SARS-CoV-2 can provide immunity and prevent reinfection. However, less is known about how the diversity, magnitude, and length of the antibody response after a primary infection is associated with symptoms, post-infection immunity, and post-vaccinated immunity.

Methods
Cook County Health employees provided blood samples and completed an online survey 8–10 weeks after a PCR-confirmed positive SARS-CoV-2 test (pre-vaccinated, N = 41) and again, 1–4 weeks after completion of a 2-dose series mRNA BNT162b2 COVID-19 vaccine (post-vaccinated, N = 27). Associations were evaluated between SARS-CoV-2 antibody titers, participant demographics, and clinical characteristics. Antibody titers and angiotensin-converting enzyme 2 (ACE2) neutralization were compared before and after the mRNA BNT162b2 COVID-19 vaccine.

Results
Antibody titers to the spike protein (ST4), receptor binding domain (RBD), and RBD mutant D614G were significantly associated with anosmia and ageusia, cough, and fever. Spike protein antibody titers and ACE2 neutralization were significantly higher in participants that presented with these symptoms. Antibody titers to the spike protein N-terminal domain (NTD), RBD, and ST4, and ACE2 IC50 were significantly higher in all post-vaccinated participant samples compared to pre-vaccinated participant sample, and not dependent on previously reported symptoms.

Conclusions
Spike protein antibody titers and ACE2 neutralization are associated with the presentation of anosmia and ageusia, cough, and fever after SARS-CoV-2 infection. Symptom response to previous SARS-CoV-2 infection did not influence the antibody response from subsequent vaccination. These results suggest a relationship between infection severity and the magnitude of the immune response and provide meaningful insights into COVID-19 immunity according to discrete symptom presentation.
The effects of laryngeal mask airway versus endotracheal tube on atelectasis in patients undergoing general anesthesia assessed by lung ultrasound: A protocol for a prospective, randomized controlled trial
Authors: Li Xuebin , Liu Bin , Wang Yaxin , Xiong Wei , Zhang Yuan , Bao Di , Liang Yi , Li Ling , Liu Gaifen , Jin Xu 
Published: September 2022

Background
The incidence of atelectasis is high in patients undergoing general anesthesia. This may cause oxygenation impairment and further contribute to postoperative pulmonary complications (PPCs). As important airway management devices for general anesthesia, few studies have compared the effects of laryngeal mask airway (LMA) and endotracheal tube (ETT) on atelectasis. Additionally, lung ultrasound has been increasingly used for bedside atelectasis diagnosis. For the above considerations, this trial is designed to compare the effects of LMA and ETT on atelectasis assessed by lung ultrasound scores, further providing more powerful clinical evidence for perioperative respiratory management of non-laparoscopic elective lower abdominal surgery under general anesthesia.

Methods
This is a prospective, single-center, single-blind, randomized controlled trial. From July 2021 to July 2022, 180 patients undergoing elective non-laparoscopic lower abdominal surgery under general anesthesia will be recruited and randomly divided into the ETT and LMA groups at a ratio of 1:1. The primary outcome is the total atelectasis LUS of 12 lung regions 15 min after the establishment of the artificial airway. The total atelectasis LUS at the end of surgery and 30 min after extubation, oxygenation index, postoperative airway complications, PPCs, and length of stay will be analyzed as secondary indicators.

Trial registration
ClinicalTrials.gov identifier: ChiCTR1900020818. Registered on January 20, 2019. Registered with the name of “Laryngeal mask airway versus endotracheal tube for atelectasis.” URL: https://www.chictr.org.cn/showproj.aspx?proj=35143.