bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment, outcome and re-vaccination of patients with SARS-CoV-2 vaccine-associated immune thrombocytopenia
Authors: Ruzicka Michael , Wurm Sonja , Lindner Lars , Dreyling Martin , von Bergwelt-Baildon Michael , Boeck Stefan , Giessen-Jung Clemens , Milani Valeria , Stemmler Joachim H. , Subklewe Marion , Weigert Oliver , Spiekermann Karsten 
Published: October 2022

Abstract
Purpose
Following the emergency use authorization of BNT162b2 by the Food and Drug administration (FDA) in early December 2020, mRNA- and vector-based vaccines became an important means of reducing the spread and mortality of the COVID-19 pandemic. The European Medicines Agency labelled immune thrombocytopenia (ITP) as a rare adverse reaction of unknown frequency after vector-, but not mRNA-vaccination. Here, we report on the long-term outcome of 6 patients who were diagnosed with de-novo, vaccine-associated ITP (VA-ITP), and on the outcome of subsequent SARS-CoV-2 re-vaccinations.

Methods
Patients were included after presenting to our emergency department. Therapy was applied according to ITP guidelines. Follow-up data were obtained from outpatient departments. Both mRNA- or vector-based vaccines were each used in 3 cases, respectively.

Results
In all patients, the onset of symptoms occurred after the 1st dose of vaccine was applied. 5 patients required treatment, 3 of them 2nd line therapy. All patients showed a complete response eventually. After up to 359 days of follow-up, 2 patients were still under 2nd line therapy with thrombopoietin receptor agonists. 5 patients have been re-vaccinated with up to 3 consecutive doses of SARS-CoV-2 vaccines, 4 of them showing stable platelet counts hereafter.

Conclusion
Thrombocytopenia after COVID-19 vaccination should trigger a diagnostic workup to exclude vaccine-induced immune thrombotic thrombocytopenia (VITT) and, if confirmed, VA-ITP should be treated according to current ITP guidelines. Re-vaccination of patients seems feasible under close monitoring of blood counts and using a vaccine that differs from the one triggering the initial episode of VA-ITP.
Optimizing BLDC motor drive performance using particle swarm algorithm-tuned fuzzy logic controller
Authors: Shi Jun , Mi Qingtao , Cao Weifeng , Zhou Lintao 
Published: October 2022

Abstract
A brushless DC (BLDC) motor is synchronous motor with trapezoidal/square wave counter-electromotive force, which is a typical example of highly coupled nonlinear systems. In industrial control, BLDC motor drive usually uses proportional–integral (PI) controller to control the speed, but it is very difficult to adjust the scale factors. In this study, we present a particle swarm algorithm-tuned fuzzy logic-PI (PF-PI) controller applied to the speed control system. The objective of this paper is to optimally tune the PI controller parameters to obtain the best drive response. The scale factors are optimized using particle swarm optimized-PI (P-PI) controller and PF-PI controller. The three performance indicators integral time absolute error (ITAE), integral time square error (ITSE) and integral square error (ISE) are used to measure the effectiveness of PF-PI controller optimization. The results show that the optimal torque ripple and speed response curves are obtained by using ITAE as the performance indicator. The conclusions demonstrate that the proposed method provides superior dynamic performance for BLDC motor.

Highlights

In terms of research content, we propose a new PF-PI controller driven control system based on the traditional BLDC speed control system, and the applicability of three performance indicators on the controller is discussed.

In terms of research method, we compare the no-load start, variable speed and sudden addition disturbance load start capabilities of P-PI controller and PF-PI controller, and verify the fast and robustness of PF-PI controller.

In the research significance, the PI controller structure is improved and the dynamic performance of BLDC speed control system is enhanced.
The Africa-Diaspora Orbit: Anani Dzidzienyo’s Contributions to African/Black Studies and Black Liberation
Authors: Gyamfi Bright 
Published: October 2022

AbstractDrawing on interviews and archival and published materials, Gyamfi reinterprets Anani Dzidzienyo’s significance as a Black Studies scholar and activist. Dzidzienyo was a pioneer in academic African diaspora studies who institutionalized the inclusion of Africa and Brazil. For fifty years, Dzidzienyo created Black Studies and Afro-Latin American programs, designed Afro-Brazilian courses that expanded Portuguese and Brazilian Studies, and supported freedom struggles in Africa and Brazil. In so doing, he built a transnational network of scholar-activists and institutions. Yet, for all this, scholars have mostly neglected Dzidzienyo’s work and wide influence on multiple fields of study and liberation movements.
A new species of the Ordovician horseshoe crab Lunataspis
Authors: Lamsdell James C. , Isotalo Phillip A. , Rudkin David M. , Martin Markus J. 
Published: October 2022

AbstractHorseshoe crabs as a group are renowned for their morphological conservatism punctuated by marked shifts in morphology associated with the occupation of non-marine environments and have been suggested to exhibit a consistent developmental trajectory throughout their evolutionary history. Here, we report a new species of horseshoe crab from the Ordovician (Late Sandbian) of Kingston, Ontario, Canada, from juvenile and adult material. This new species provides critical insight into the ontogeny and morphology of the earliest horseshoe crabs, indicating that at least some Palaeozoic forms had freely articulating tergites anterior to the fused thoracetron and an opisthosoma comprising 13 segments.
Disease, DPs, and DDT: A Global Health Perspective on the History of Refugee Relief
Authors: Bailey Roderick 
Published: October 2022

AbstractAt the end of the Second World War, millions of men, women, and children shared a similar experience: delousing, at the hands of Allied armies and relief agencies, to prevent the spread of infectious disease. The procedure lasted seconds. In studies of displaced populations in this period, its effects upon them are commonly presented as invasive, humiliating, and, for some, reminiscent of Nazi abuse. Adopting a wider lens, this article explores how events and developments in a global range of settings shaped demands for effective delousing as well as the character of measures devised to achieve it. Harnessing fresh perspectives on how delousing was managed, delivered, and experienced, the article also advances understanding of how refugees responded to it.
Health risk and the welfare effects of Social Security
Authors: Bagchi Shantanu , Jung Juergen 
Published: October 2022

AbstractWe quantify the importance of idiosyncratic health risk in a calibrated general equilibrium model of Social Security. We construct an overlapping generations model with rational-expectations households, idiosyncratic labor income and health risk, profit-maximizing firms, incomplete insurance markets, and a government that provides pensions and health insurance. We calibrate this model to the US economy and perform two computational experiments:
$\left (i\right)$
cutting Social Security’s payroll tax, and
$\left (ii\right)$
modifying Social Security’s benefit-earnings rule. Our findings suggest that health risk amplifies the welfare implications of both experiments: downsizing Social Security always leads to higher overall welfare, but the welfare gain is larger when we account for health risk, and increasing the progressivity of Social Security’s benefit-earnings rule has a larger positive effect on welfare in the presence of health risk. We also find that allowing households additional tools to self-insure against health risk weakens the precautionary motive, so our experiments have similar welfare implications both with and without health risk.
Characterizing sorghum (Sorghum bicolor [L.] Moench) varieties diversity to identify those with contrasting traits of interest for intercropping systems in the Sudano-Sahelian zone of West Africa
Authors: Ganeme Aminata , Kondombo Clarisse Pulchérie , Raboin Louis-Marie , Dusserre Julie , Kabore Roger , Adam Myriam , Traoré Salifou 
Published: October 2022

AbstractSorghum is an important staple crop in Sub-Saharan Africa. In the Sudano-Sahelian zone of West Africa, sorghum is mainly intercropped with cowpea, but these intercropping systems are facing low-productivity problems. The overall aim of this research was to identify sorghum varieties with different agro-morphological and physiological traits that could improve the performance of the intercropping systems. We followed a two-step methodology comprising (i) identification of varieties and plant traits of interest in intercropping systems, using participatory methods, and (ii) agro-morpho-physiological characterization of 50 sorghum varieties, to examine the range of variation in traits of interest. The results show that landraces are the varieties most widely used by farmers, and that 82.5% of farmers consider the variety type they choose for intercropping to be important. Farmers mentioned plant height, number of leaves and stem diameter as important traits to consider. Analysis of variance showed significant differences between varieties for half of the 24 agro-morpho-physiological traits studied. Hierarchical clustering identified three main groups of varieties, distinguished by morphological traits such as stem diameter, total number and size of leaves (group 1), root traits (depth, growth angle, dry matter) and relative chlorophyll content (groups 2 and 3). Based on this classification, we recommend several varieties from each of the three groups, exhibiting contrasting traits, for an assessment of their performances in intercropping systems.
The Effect of Surface Heating Heterogeneity on Boundary Layer Height and Its Dependence on Background Wind Speed
Authors: Liu Rui , Liu Shaofeng , Huang Huishan , Dai Yongjiu , Zeng Xubin , Yuan Hua , Wei Zhongwang , Lu Xingjie , Wei Nan , Zhang Shupeng , Wei Junhong 
Published: October 2022

AbstractThe planetary boundary layer height (PBLH) is a fundamental variable of the planetary boundary layer (PBL). The effect of surface heterogeneity is challenging in the PBL parameterization for numerical weather and climate models. Here we use large eddy simulation data to investigate the impact of surface heating heterogeneity on the PBLH spatial variations and mean values over a domain of typical mesoscale model grid size. It is found that this impact depends on background wind condition. Variance decomposition and Fourier spectra both reveal that for the fully developed sheared convective PBL, surface heterogeneity contributes little to the spatial variation of PBLH, except for the case with heterogeneity scale of 14.4 km. This suggests that surface heterogeneity with length scales less than ∼10 km, which is typical for mesoscale modeling, does not induce significant subgrid spatial variation of PBLH. The domain‐averaged PBLH is found to generally increase as surface heterogeneity scale decreases, until reaching the scale on the order of PBLH. The findings can be used to inform the parameterization development of PBL processes over heterogeneous surface.
Tidal Constraints on the Martian Interior
Authors: Pou L. , Nimmo F. , Rivoldini A. , Khan A. , Bagheri A. , Gray T. , Samuel H. , Lognonné P. , Plesa A.‐C. , Gudkova T. , Giardini D. 
Published: October 2022

AbstractWe compare several recent Martian interior models and evaluate how these are impacted by the tidal constraints provided by the Love number k2 and the secular acceleration in longitude s of its main moon, Phobos. The expression of the latter is developed up to harmonic degree 5 to match the accuracy of the current observations. We match a number of current interior structure models to the recent measurements of the tidal parameters and derive estimations of the possible core radius, temperature profile, and attenuation in the Martian interior. Our estimation of the core radius is 1,820 ± 80 km, consistent with recent seismic measurements. The attenuation profiles in the Martian interior at the main tidal period of Phobos are similar between the considered models, giving a range for the degree‐2 bulk tidal attenuation Q2 = 93.0 ± 8.40 but diverge at seismic frequencies. At seismic frequencies, model shear attenuation Qμ ranges between 100 and 4,000 in the lower mantle, so that a measurement of seismic shear attenuation could be used as an effective means for distinguishing between the models considered. Other constraints such as elastic lithosphere thickness and Chandler Wobble period favor a thicker elastic lithosphere and models with a frequency dependence α of the shear attenuation between 0.15 and 0.4. Improved constraints on the Martian interior should be possible with additional seismic and radio observations from the InSight mission.
Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer
Authors: Tang Xiaolong , Liang Yahang , Sun Guorui , He Qingsi , Hou Zhenyu , Jiang Xingzhi , Gao Peng , Qu Hui 
Published: October 2022

AbstractOxaliplatin is the main chemotherapy drug for gastric cancer (GC), but quite a few patients are resistant to oxaliplatin, which contributes to the poor prognosis of GC patients. There is therefore an urgent need to identify potential targets for reversing chemotherapy resistance in GC patients. In this study, we analyzed the tumor samples of GC patients who received neoadjuvant chemotherapy based on oxaliplatin through quantitative proteomics and identified the potential chemoresistance-related protein cellular retinoic acid binding protein 2 (CRABP2). CRABP2 was significantly upregulated in the tumor tissues of chemoresistant GC patients and was closely related to prognosis. The results of cell function experiments showed that CRABP2 can promote the oxaliplatin resistance of GC cells in vitro. Coimmunoprecipitation and GST pulldown assays showed that CRAPB2 expedited the binding of BAX and PARKIN in GC cells and facilitated the ubiquitination-mediated degradation of BAX. Furthermore, both the in vitro assay and cell-derived xenograft (CDX) in vivo model verified that CRABP2 promoted oxaliplatin resistance by inhibiting BAX-dependent cell apoptosis. Further experiments proved that the abnormally high expression of CRABP2 in oxaliplatin-resistant GC cells was affected by TET1-mediated DNA hydroxymethylation. The patient-derived xenograft (PDX) model suggested that interference with CRABP2 reversed oxaliplatin resistance in GC in vivo. In conclusion, the results of our study show that CRABP2 was a key molecule in oxaliplatin resistance regulation and could be a new target for reversing the chemoresistance of GC.
Integrated stress response is involved in the 24(S)-hydroxycholesterol-induced unconventional cell death mechanism
Authors: Urano Yasuomi , Osaki Shoya , Chiba Ren , Noguchi Noriko 
Published: October 2022

AbstractPerturbation of proteostasis triggers the adaptive responses that contribute to the homeostatic pro-survival response, whereas disruption of proteostasis can ultimately lead to cell death. Brain-specific oxysterol—i.e., 24(S)-hydroxycholesterol (24S-OHC)—has been shown to cause cytotoxicity when esterified by acyl-CoA:cholesterol acyltransferase 1 (ACAT1) in the endoplasmic reticulum (ER). Here, we show that the accumulation of 24S-OHC esters caused phosphorylation of eukaryotic translation initiator factor 2α (eIF2α), dissociation of polysomes, and formation of stress granules (SG), resulting in robust downregulation of global protein de novo synthesis in human neuroblastoma SH-SY5Y cells. We also found that integrated stress response (ISR) activation through PERK and GCN2 activation induced by 24S-OHC treatment caused eIF2α phosphorylation. 24S-OHC-inducible SG formation and cell death were suppressed by inhibition of ISR. These results show that ACAT1-mediated 24S-OHC esterification induced ISR and formation of SG, which play crucial roles in 24S-OHC-inducible protein synthesis inhibition and unconventional cell death.
Proteotoxic stress-induced apoptosis in cancer cells: understanding the susceptibility and enhancing the potency
Authors: Iuliano Luca , Dalla Emiliano , Picco Raffaella , Mallavarapu Showmeya , Minisini Martina , Malavasi Eleonora , Brancolini Claudio 
Published: October 2022

AbstractLeiomyosarcoma (LMS) is aggressive cancer with few therapeutic options. LMS cells are more sensitive to proteotoxic stress compared to normal smooth muscle cells. We used small compound 2c to induce proteotoxic stress and compare the transcriptomic adaptations of immortalized human uterine smooth muscle cells (HUtSMC) and LMS cells SK-UT-1. We found that the expression of the heat shock proteins (HSPs) gene family is upregulated with higher efficiency in normal cells. In contrast, the upregulation of BH3-only proteins is higher in LMS cells. HSF1, the master regulator of HSP transcription, is sequestered into transcriptionally incompetent nuclear foci only in LMS cells, which explains the lower HSP upregulation. We also found that several compounds can enhance the cell death response to proteotoxic stress. Specifically, when low doses were used, an inhibitor of salt-inducible kinases (SIKs) and the inhibitor of IRE1α, a key element of the unfolded protein response (UPR), support proteotoxic-induced cell death with strength in LMS cells and without effects on the survival of normal cells. Overall, our data provide an explanation for the higher susceptibility of LMS cells to proteotoxic stress and suggest a potential option for co-treatment strategies.
Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease
Authors: De Chiara Letizia , Conte Carolina , Semeraro Roberto , Diaz-Bulnes Paula , Angelotti Maria Lucia , Mazzinghi Benedetta , Molli Alice , Antonelli Giulia , Landini Samuela , Melica Maria Elena , Peired Anna Julie , Maggi Laura , Donati Marta , La Regina Gilda , Allinovi Marco , Ravaglia Fiammetta , Guasti Daniele , Bani Daniele , Cirillo Luigi , Becherucci Francesca , Guzzi Francesco , Magi Alberto , Annunziato Francesco , Lasagni Laura , Anders Hans-Joachim , Lazzeri Elena , Romagnani Paola 
Published: October 2022

AbstractAcute kidney injury (AKI) is frequent, often fatal and, for lack of specific therapies, can leave survivors with chronic kidney disease (CKD). We characterize the distribution of tubular cells (TC) undergoing polyploidy along AKI by DNA content analysis and single cell RNA-sequencing. Furthermore, we study the functional roles of polyploidization using transgenic models and drug interventions. We identify YAP1-driven TC polyploidization outside the site of injury as a rapid way to sustain residual kidney function early during AKI. This survival mechanism comes at the cost of senescence of polyploid TC promoting interstitial fibrosis and CKD in AKI survivors. However, targeting TC polyploidization after the early AKI phase can prevent AKI-CKD transition without influencing AKI lethality. Senolytic treatment prevents CKD by blocking repeated TC polyploidization cycles. These results revise the current pathophysiological concept of how the kidney responds to acute injury and identify a novel druggable target to improve prognosis in AKI survivors.
Wax worm saliva and the enzymes therein are the key to polyethylene degradation by Galleria mellonella
Authors: Sanluis-Verdes A. , Colomer-Vidal P. , Rodriguez-Ventura F. , Bello-Villarino M. , Spinola-Amilibia M. , Ruiz-Lopez E. , Illanes-Vicioso R. , Castroviejo P. , Aiese Cigliano R. , Montoya M. , Falabella P. , Pesquera C. , Gonzalez-Legarreta L. , Arias-Palomo E. , Solà M. , Torroba T. , Arias C. F. , Bertocchini F. 
Published: October 2022

AbstractPlastic degradation by biological systems with re-utilization of the by-products could be a future solution to the global threat of plastic waste accumulation. Here, we report that the saliva of Galleria mellonella larvae (wax worms) is capable of oxidizing and depolymerizing polyethylene (PE), one of the most produced and sturdy polyolefin-derived plastics. This effect is achieved after a few hours’ exposure at room temperature under physiological conditions (neutral pH). The wax worm saliva can overcome the bottleneck step in PE biodegradation, namely the initial oxidation step. Within the saliva, we identify two enzymes, belonging to the phenol oxidase family, that can reproduce the same effect. To the best of our knowledge, these enzymes are the first animal enzymes with this capability, opening the way to potential solutions for plastic waste management through bio-recycling/up-cycling.
Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage
Authors: Arakawa Noriaki , Ushiki Atsuhito , Abe Mitsuhiro , Matsuyama Shinichiro , Saito Yoshinobu , Kashiwada Takeru , Horimasu Yasushi , Gemma Akihiko , Tatsumi Koichiro , Hattori Noboru , Tsushima Kenji , Miyashita Keiko , Saito Kosuke , Nakamura Ryosuke , Toyoda Takeshi , Ogawa Kumiko , Sato Motonobu , Takamatsu Kazuhiko , Mori Kazuhiko , Nishiya Takayoshi , Izumi Takashi , Ohno Yasuo , Saito Yoshiro , Hanaoka Masayuki 
Published: October 2022

AbstractAmong the various histopathological patterns of drug-induced interstitial lung disease (DILD), diffuse alveolar damage (DAD) is associated with poor prognosis. However, there is no reliable biomarker for its accurate diagnosis. Here, we show stratifin/14-3-3σ (SFN) as a biomarker candidate found in a proteomic analysis. The study includes two independent cohorts (including totally 26 patients with DAD) and controls (total 432 samples). SFN is specifically elevated in DILD patients with DAD, and is superior to the known biomarkers, KL-6 and SP-D, in discrimination of DILD patients with DAD from patients with other DILD patterns or other lung diseases. SFN is also increased in serum from patients with idiopathic DAD, and in lung tissues and bronchoalveolar lavage fluid of patients with DAD. In vitro analysis using cultured lung epithelial cells suggests that extracellular release of SFN occurs via p53-dependent apoptosis. We conclude that serum SFN is a promising biomarker for DAD diagnosis.
Global forestation and deforestation affect remote climate via adjusted atmosphere and ocean circulation
Authors: Portmann Raphael , Beyerle Urs , Davin Edouard , Fischer Erich M. , De Hertog Steven , Schemm Sebastian 
Published: October 2022

AbstractForests can store large amounts of carbon and provide essential ecosystem services. Massive tree planting is thus sometimes portrayed as a panacea to mitigate climate change and related impacts. Recent controversies about the potential benefits and drawbacks of forestation have centered on the carbon storage potential of forests and the local or global thermodynamic impacts. Here we discuss how global-scale forestation and deforestation change the Earth’s energy balance, thereby affect the global atmospheric circulation and even have profound effects on the ocean circulation. We perform multicentury coupled climate model simulations in which preindustrial vegetation cover is either completely forested or deforested and carbon dioxide mixing ratio is kept constant. We show that global-scale forestation leads to a weakening and poleward shift of the Northern mid-latitude circulation, slows-down the Atlantic meridional overturning circulation, and affects the strength of the Hadley cell, whereas deforestation leads to reversed changes. Consequently, both land surface changes substantially affect regional precipitation, temperature, clouds, and surface wind patterns across the globe. The design process of large-scale forestation projects thus needs to take into account global circulation adjustments and their influence on remote climate.