bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lymphedema as a Meteoropathic Disease Based on a Retrospective Study in a Single Institute: a Preliminary Report
Authors: Suzuki Motomu , Koukichi Koukichi , Mikami Taro , Yabuki Yuichiro , Asano Saori , Kitayama Shinya , Kagimoto Shintaro , Iwai Toshinori , Sugiyama Satomi , Yasumura Kazunori , Maegawa Jiro 
Published: January 2022

Abstract
Since cellulitis is one of the most important factors for the prognosis of lymphedema, the prevention and prediction of cellulitis are considered to be critical in controlling lymphedema. We hypothesized that patients with lymphedema might show meteoropathy, as abdominal aortic aneurysm ruptures are considered to be influenced by climatic conditions, and the lymphatic system is one of the circulation systems. Thus, we aimed to determine if the onset of cellulitis in limbs affected by lymphedema is related to climatic conditions. We reviewed the clinical records of patients with lymphedema admitted for cellulitis at our institute between January 2007 and December 2017. We identified 40 patients, 25 of whom lived in the same area. We examined the association between the number of patient admissions according to season and meteorological data obtained from the Japan Meteorological Agency database. Thirteen of 25 patients were admitted in summer, whereas only one patient was admitted in winter. Both higher temperature and lower atmospheric pressure around the day of admission were associated with the occurrence of cellulitis. Lymphedema may be regarded as a meteoropathic disease, as climatic conditions were shown to be associated with cellulitis in limbs affected by lymphedema.
Acetylated African Oil Bean Seed Pod For Crude Oil Spill Mop
Authors: Obi Amalachukwu Ifeyinwa , Ajiwe Vincent Ishmael 
Published: January 2022

Abstract
Oil spill remediation has continued to be a challenge in the world today. Thus efforts are still been made to develop more efficient oil spill mop up techniques. Natural adsorption with agricultural wastes, which otherwise constitute environmental pollution, has become an attractive technique for oil spill mop. Acetylation using acetic anhydride with iodine catalyst was carried out to improve the hydrophobicity of African oil bean seed pod (AOBSP), which is a lignocellulosic material and as such is naturally hydrophilic. Characterization of the raw and acetylated AOBSP were done using SEM, BET and FTIR analyses. Batch crude oil sorption tests were performed using both the raw and acetylated AOBSP. Isotherm, kinetic and thermodynamic studies were also carried out. FTIR analysis showed evidence of successful acetylation of AOBSP and adsorption of crude oil onto the raw and acetylated AOBSP. SEM and BET analyses showed improvement of the surface properties of AOBSP by the acetylation process. The BET surface area increased from 226.4 m2/g for the raw AOBSP to 310.0 m2/g for the acetylated AOBSP. Oil sorption was found to be by monolayer coverage, with monolayer sorption capacity of 5000mg/g and 12500mg/g for raw and acetylated AOBSP, respectively. The rate-controlling mechanism for the sorption processes was chemisorption. Negative values of ΔGo, ΔHo and ΔSo were obtained, showing that the sorption processes were feasible, spontaneous and exothermic, with a degree of orderliness at the solid–mixture interface. The results obtained from this study show that both raw and acetylated AOBSP are efficient oil sorbents with potentials for further improvement for oil spill mop.
Silk Microlens Array
Authors: Choi Seung Ho , Ho Tien Son , Effah Elijah , Nettey-Oppong Ezekiel Edward , Choi Seungyeop , Choi Ji Hyeon , Jung Byungjo , Lee Sang Woo , Kim Kee Young , Kim Seong-Wan , Byun Kyung Min 
Published: January 2022

Abstract
Optics that are capable of merging with biomaterials create a variety of opportunities for sensing disease, for therapeutics, and for augmenting brain-machine interface. The FDA has approved silk devices for sutures and reconstructive surgery. Recently, a silk product made from regenerated silk protein is FDA approved for orthopedic application, as the understanding of structure and processing technologies of silk fibroin has been improved. Here, we report a facile fabrication process to construct silk microlens array. The process includes preparation of regenerated silk solution and casting on a micropatterned poly(dimethylsiloxane) (PDMS) master. Due to the identical surface area of a unit patterned regime, the silk solution exhibits a partial wetting state in the vicinity of the silk solution–PDMS–vapor interface with same contact angle, and after drying, produces consistent radius of curvature within the microlens array. This in turn provides highly uniform focal length, focal spot diameter, and imaging performance of individual lens. Our results provide the foundation for biophotonic microlens adding new capabilities for implantable and degradable devices from regenerated silk protein.
Infant and Young child feeding practice and associated factors among 0-23 months of children in irrigated and non-irrigated area of Dangila district, North West of Ethiopia
Authors: Belayneh Melesse , Tirfie Mulat , Mekonen wasihun 
Published: January 2022

Abstract
Background

Infant and young child feeding practice is a cornerstone of care for child development mentally and growth physically. Failure to proper infant and young child feeding practice is associated with increased risk of childhood morbidity and mortality.
Objective

To assess the prevalence of infant and young child feeding practice among 0-23 months of age children in irrigated and non-irrigated area of Dangila Woreda, North-west Ethiopia, 2021.
Methods

Community based comparative cross-sectional study was conducted from Dec 1, 2020 to Jun 1, 2021 with a total of 823 mothers who have infant and young children 0-23monthes of age in 9 selected Keebles were included in the study. Stratified sampling technic was implemented to select irrigated and non- irrigated kebeles and study units. Data was collected by face to face interview method. bivariate and multivariate analysis were used, variables with p<0.05, was taken as statistically significant and independently associated with infant and young child feeding practice. Adjusted odds ratio along with 95% confidence interval was used to assess the strength of the association.
Result

Among 823 households visited, 802 participants gave complete responses with response rate of 97.4%. The overall prevalence infant and young child feeding practice was 62.5%, of these 72.8%(95%CI: 67.5%, 76.1%)from irrigated and 52.2%(95%CI: 47.8%, 57.4%), from non-irrigated area had good practice of IYCF. Moreover, the study identified that ANC (AOR= 2.138, 95% CI: 1.085, 4.210), knowledge (AOR= 2.43, 95% CI: 0.275, 0.612), attitude (AOR= 1.687, 95% CI: 1.129, 2.520), PNC (AOR= 1.606, 95% CI: 1.154, 2.360) and women’s decision making (AOR= 1.941, 95% CI: 1.305, 2.888) were significant predictor for IYCF among 0-23months of age children.
Conclusion

The overall prevalence of infant and young child feeding practice was (62.5%) in the study area and had shown significant variation between irrigated and non-irrigated area. Infant and young child feeding practice is high as compared previous study. Women’s decision making, ANC follow up, PNC follow up, attitude and knowledge were identified as the intervention areas..
The Relationship Between Structural Analysis of the Hand and Clinical Characteristics in Psoriatic Arthritis
Authors: Pfeil Alexander , Heinz Marcus , Hoffmann Tobias , Weise Tobias , Renz Diane , Franz Marcus , Malich Ansgar , Driesch Dominik , Oelzner Peter , Wolf Gunter , Böttcher Joachim 
Published: January 2022

Abstract
Background:Up to now, there is only limited information available on a possible relationship between clinical characteristics and the mineralization of metacarpal bones and finger joint space distance (JSD) in patients with psoriasis arthritis (PsA). Computerized digital imaging techniques like digital X-ray radiogrammetry (DXR) and computer-aided joint space analysis (CAJSA) have significantly improved the structural analysis of hand radiographs and facilitate the recognition of radiographic damage. The objective of this study was to evaluate clinical features which potentially influence periarticular mineralization of the metacarpal bones and finger JSD in PsA-patients. Methods:201 patients with PsA underwent computerized measurements of the metacarpal bone mineral density (BMD) with DXR and JSD of all finger joints by CAJSA. DXR-BMD and JSD were compared with clinical features such as age and sex, disease duration, C-reactive protein (CRP) as well as treatment with prednisone and disease-modifying antirheumatic drugs (DMARDs).Results:A longer disease duration and an elevated CRP value were associated with a significant reduction of DXR-BMD, whereas JSD-parameters were not affected by both parameters. DXR-BMD was significantly reduced in the prednisone group (-6.6%), but prednisone showed no impact on finger JSD. Patients under the treatment with bDMARDs presented significant lower DXR-BMD (-9.1%), JSDMCP (-16.8%), and JSDPIP (-12.4%) values. Conclusion:Metacarpal BMD was influenced by inflammatory activity, prednisone use, and DMARDs. In contrast, finger JSD showed only a change compared to baseline therapy. Therefore, metacarpal BMD as well as finger JSD represent radiographic destruction under different aspects.
COVID-19 vaccination is highly effective to prevent SARS-CoV-2 circulation
Authors: Mattiuzzi Camilla , Lippi Giuseppe 
Published: January 2022

Abstract
Background: We provide here an analysis of effectiveness of primary coronavirus disease 2019 (COVID-19) vaccination and COVID-19 vaccine booster doses in preventing severe acute respiratory syndrome coronavirus 2 (COVID-19) infection.Methods: We retrieved information on COVID-19 vaccination and newly diagnosed cases of SARS-CoV-2 infection from the weekly official report of the Italian National Institute of Health (Istituto Superiore di Sanità, ISS; Last available update, January 1, 2022).Results: At the time of our analysis, 39.9 million people completed a primary COVID-19 vaccination cycle, of whom 13.6 million (34.0%) <5 months from the last dose, whilst 5.7 million had also received COVID-19 vaccine booster doses. The risk of SARS-CoV-2 infection was 71% (OR, 0.29; 95%CI, 0.29-0.29) and 86% (OR, 0.14; 95%CI, 0.14-0.14) lower in people who received primary vaccination <5 months and booster doses <5 months compared to the unvaccinated population, but was also half (OR, 0.49; 95%CI, 0.48-0.49) in those who received booster doses <5 months compared to those who completed the primary vaccination <5 months.Conclusions: These results attest that COVID-19 vaccines not only reduce the risk of developing severe illness in patients with SARS-CoV-2 infection, but shall also be considered reliable and effective means to limit virus circulation within the general population.
Nanoplasmonic Pyramidal Metamaterial Absorber at Optical Frequencies
Authors: Amin Muhammad , Basamed Saleh Abdullah , Qniqoon Ahmed Salem , Alshabibi Faisal Aied , Raean Saleh Mohammed Ba , Aldhlea Hamad Edhah 
Published: January 2022

Abstract
A pyramidal shaped metamaterial absorber (PMA) supports broadband and polarization independent resonant absorption at optical frequencies. The PMA is designed by stack of alternative plasmonic/dielectric multilayers. These nanoplasmonic pyramids offers resonant absorption characteristics at wide range of optical frequencies. The optimized PMA structure allows 76% spectral absorption and nearly perfect absorption (over 90%) at several bands between range of 400 nm – 1500 nm wavelength. These light absorption characteristics of PMA are useful for photodetection, thermal imaging, thermal emitters, and solar cells etc.
miR-489 Confines Uncontrolled Estrogen Signaling Through a Negative Feedback Mechanism and Regulates Tamoxifen Resistance in Breast Cancer
Authors: Soni Mithil , Saatci Ozge , Gupta Gourab , Patel Yogin , Raja Manikanda Raja Keerthi , Li Jie , Liu Xinfeng , Xu Peisheng , Wang Hongjun , Fan Daping , Sahin Ozgur , Chen Hexin 
Published: January 2022

Abstract
Background: Approximately 75% of diagnosed breast cancer tumors are estrogen-receptor (ER) positive tumors and are associated with better prognosis due to their response to hormonal therapies. However, around 40% of patients relapse after hormonal therapies. In the current study, we aim to evaluate miR-489 as a novel molecular target to combat tamoxifen resistance. Methods: Genomic analysis of gene expression profiles in primary breast cancers and tamoxifen resistant cell lines unveiled the potential role of miR-489 in regulation of estrogen signaling and development of tamoxifen resistance. We manipulated miR-489 expression in breast cancer cell lines by transient transfection of a miR-489 mimic or establishment of knockout cell lines using the CRISPR/Cas9 system to study the reciprocal regulation of miR-489 and estrogen/ER signaling pathways. Cell proliferation assays, Sphere-formation assays and flow cytometry analysis were conducted to investigate the role of miR-489 in estrogen-induced cell proliferation, cancer stem cell expansion and development of tamoxifen resistance. Results: miR-489 expression was significantly downregulated in tamoxifen-resistant cell lines. Low levels of miR-489 were associated with poor clinical outcomes in patients with hormone treatment. In vitro analysis showed that loss of miR-489 expression promoted tamoxifen resistance while overexpression of miR-489 in tamoxifen-resistant cells restored tamoxifen sensitivity. Mechanistically, we found that miR-489 is an estrogen regulated miRNA that negatively regulated estrogen receptor signaling by using at least the following two mechanisms: i) modulation of ER phosphorylation status by inhibiting MAPK and AKT kinase activities and downregulating SHP2 expression; ii) regulation of nucleus to cytosol translocation of estrogen receptor α (ERα) by decreasing p38 expression and consequently ER phosphorylation. In addition, miR-489 could break the positive feed-forward loop between the estrogen-ERα axis and p38 MAPK in breast cancer cells, which was necessary for its function as a transcription factor. Conclusion: Our study unveiled the underlying molecular mechanism by which miR-489 regulates estrogen signaling pathway through a negative feedback loop and uncovered its role in both the development of and overcoming of tamoxifen resistance in breast cancers.
Discrete Equilibrium Optimizer Combined with Simulated Annealing for Feature Selection
Authors: Guha Ritam , Ghosh Kushal Kanti , Bera Suman Kumar , Sarkar Ram , Mirjalili Seyedali 
Published: January 2022

Abstract
This paper proposes a binary adaptation of the recently proposed meta-heuristic, Equilibrium Optimizer (EO), called Discrete EO (DEO) to solve binary optimization problems. A U-shaped transfer function has been used to map the continuous values of EO into the binary domain. To further improve the exploitation capability of DEO, Simulated Annealing (SA) has been used as a local search procedure and the combination has been named as DEOSA. The proposed DEOSA algorithm has been applied over 18 well-known UCI datasets and compared with a wide range of algorithms. The results have been statistically validated using Wilcoxon rank-sum test. In order to test the scalability and robustness of DEOSA, it has been additionally tested over 7 high-dimensional Microarray datasets and 25 binary Knapsack problems. The results clearly demonstrate the superiority and merits of DEOSA when solving binary optimization problems.
Fuzzy Proximity based Robust Data Hiding Scheme with Interval Threshold
Authors: Singh Prabhas Kumar , Jana Biswapati , Datta Kakali 
Published: January 2022

Abstract
In 2020, Ashraf et al. proposed an interval type-2 fuzzy logic based block similarity calculation using color proximity relations of neighboring pixels in a steganographic scheme. Their method works well for detecting similarity, but it has drawbacks in terms of visual quality, imperceptibility, security, and robustness. Using Mamdani fuzzy logic to identify color proximity at the block level, as well as a shared secret key and post-processing system, this paper attempts to develop a robust data hiding scheme with similarity measure to ensure good visual quality, robustness, imperceptibility, and enhance the security. Further, the block color proximity is graded using an interval threshold. Accordingly, data embedding is processed in the sequence generated by the shared secret keys. In order to increase the quality and accuracy of the recovered secret message, the tampering coincidence problem is solved through a post-processing approach. The experimental analysis, steganalysis and comparisons clearly illustrate the effectiveness of the proposed scheme in terms of visual quality, structural similarity, recoverability and robustness.
Beyond “Sex Prediction”: Estimating and Interpreting Multivariate Sex Differences and Similarities in the Brain
Authors: Sanchis-Segura Carla , Aguirre Naiara , Cruz-Gómez Álvaro Javier , Félix Sonia , Forn Cristina 
Published: January 2022

Abstract
Previous studies have shown that machine-learning (ML) algorithms can “predict” sex based on brain anatomical/ functional features. The high classification accuracy achieved by ML algorithms is often interpreted as revealing large differences between the brains of males and females and as confirming the existence of “male/female brains”. However, classification and estimation are quite different concepts, and using classification metrics as surrogate estimates of between-group differences results in major statistical and interpretative distortions. The present study illustrates these distortions and provides a novel and detailed assessment of multivariate sex differences in gray matter volume (GMVOL) that does not rely on classification metrics. Moreover, modeling and clustering techniques and analyses of similarities (ANOSIM) were used to identify the brain areas that contribute the most to these multivariate differences, and to empirically assess whether they assemble into two sex-typical profiles. Results revealed that multivariate sex differences in GMVOL: 1) are “large” if not adjusted for total intracranial volume (TIV) variation, but “small” when controlling for this variable; 2) differ in size between individuals and also depends on the ML algorithm used for their calculation 3) do not stem from two sex-typical profiles, and so describing them in terms of “male/female brains” is misleading.
Effects of Long-Acting Muscarinic Antagonists on Promoting Ciliary Function in Airway Epithelium
Authors: Katsumata Mineo , Fujisawa Tomoyuki , Kamiya Yosuke , Tanaka Yuko , Kamiya Chiaki , Inoue Yusuke , Hozumi Hironao , Karayama Masato , Suzuki Yuzo , Furuhashi Kazuki , Enomoto Noriyuki , Nakamura Yutaro , Inui Naoki , Maekawa Masato , Setou Mitsutoshi , Watanabe Hiroshi , Ikegami Koji , Suda Takafumi 
Published: January 2022

Abstract
Background

Mucociliary clearance (MCC) is an essential defense mechanism in airway epithelia for removing pathogens from the respiratory tract. Impaired ciliary functions and MCC have been demonstrated in asthma and chronic obstructive pulmonary disease (COPD). Long-acting muscarinic antagonists (LAMAs) are a major class of inhaled bronchodilators, which are used for treating asthma and COPD; however, the effects of LAMAs on ciliary function remain unclear. This study aimed to identify the effects of LAMAs on airway ciliary functions.
Methods

Wild-type BALB/c mice were treated with daily intranasal administrations of glycopyrronium for 7 days, and tracheal samples were collected. Cilia-driven flow and ciliary activity, including ciliary beat frequency (CBF), ciliary beating amplitude, effective stroke velocity, recovery stroke velocity and the ratio of effective stroke velocity to recovery stroke velocity, were analyzed by imaging techniques. Using in vitro murine models, tracheal tissues were transiently cultured in media with/without LAMAs, glycopyrronium or tiotropium, for 60 min. Cilia-driven flow and ciliary activity were then analyzed. Well-differentiated normal human bronchial epithelial (NHBE) cells were treated with glycopyrronium, tiotropium, or vehicle for 60 min, and CBF was evaluated. Several mechanistic analyses were performed.
Results

Intranasal glycopyrronium administration for 7 days significantly increased cilia-driven flow and ciliary activity in murine airway epithelium. In the murine tracheal organ culture models, treatment with glycopyrronium or tiotropium for 60 min significantly increased cilia-driven flow and ciliary activity in airway epithelium. Further, we confirmed that 60-min treatment with glycopyrronium or tiotropium directly increased CBF in well-differentiated NHBE cells. In the mechanistic analyses, neither treatment with glycopyrronium nor tiotropium affected intracellular calcium ion concentrations in well-differentiated NHBE cells. Glycopyrronium did not increase protein kinase A activity in well-differentiated NHBE cells. Moreover, glycopyrronium had no effect on extracellular adenosine triphosphate concentration.
Conclusions

LAMAs exert a direct effect on airway epithelium to enhance ciliary function, which may improve impaired MCC in asthma and COPD. Further investigations are warranted to elucidate the underlying mechanisms of the effects of LAMAs on the promotion of airway ciliary function.
Pilimiction, A Rare Presentation of Ovarian Teratoma: A Case Report
Authors: Issack Feysel Hassen , Hassen Seid Mohammed , Hassen Seid Kedir , Gebreselassie Kaleab Habtemichael , Mummed Ferid Ousman , Hassen Ibsa Kedir 
Published: January 2022

Abstract
Background: Adnexal teratoma involving the urinary bladder is a very rare condition. Presentation is variable ranging from irritative LUTS (lower urinary tract symptoms) to pilimiction or trichiuria (passage of hair in the urine).Case presentation: We report a case of a 42-year-old woman who presented with pilimiction and lower abdominal pain. Contrast-enhanced computed tomography scan (CECT) and Cystoscopy were used for the diagnosis. Tumor markers were negative. Right side salpingo-oophorectomy and partial bladder wall excision were performed. Histopathology of the specimen showed features consistent with mature teratoma. The Patient-reported improvement of symptoms in the subsequent follow-up visits.Conclusion: Pilimiction is a pathognomonic sign of bladder teratomas. Therefore, it is wise to think of this pathology in patients who report the passage of hair through the urine (trichiuria or pilimiction), as in our case. Cystoscopy and cross-sectional imaging aided in the initial diagnosis. However, a definitive diagnosis was provided by histopathology.We performed right-side salpingo-oophorectomy and partial cystectomy. Transurethral resection is associated with a high recurrence rate and is not recommended for secondary bladder teratomas.