bluuebunny/crossref_metadata_2025_split huggingface dataset:
Holocene shore‐level changes, southern Lolland and the Femern Belt, Denmark
Authors: Bennike Ole , Philippsen Bente , Groẞ Daniel , Jessen Catherine 
Published: October 2022

ABSTRACTWe propose a new shore‐level displacement curve for southern Lolland and the Femern Belt in south‐eastern Denmark based on 94 new and four published radiocarbon ages of organic material and shells of marine molluscs. Mires existed in the deeper parts of the Femern Belt during the Early Holocene, and a large lake formed as the water level gradually rose. The lake phase was followed first by a brackish‐water phase from c. 8500 cal a
bp and by a marine phase after c. 7800 cal a
bp when the relative sea level was ~8 m lower than at present. Over the past 6500 years the sea level has gradually risen by ~2 m and reached its highest level in recent times. There are no indications of a higher than present sea level in the area and no indications of 1–2 m sea‐level oscillations as reported from other parts of the region. The relative sea‐level curve for southern Lolland differs from relative sea‐level curves from northern parts of Denmark, which are more influenced by glacio‐isostatic uplift. Southern Lolland has been uplifted by 4–5 m over the last 8000 years, whereas the Limfjord region in northern Denmark has been uplifted by around 12 m during the same period.
Single‐Port Transaxillary Robotic Modified Radical Neck Dissection (STAR‐RND): Initial Experiences
Authors: Ho Joon , Kim Donggyu , Lee Ji‐Eun , Kim Jin Kyong , Lee Cho Rok , Kang Sang‐Wook , Jeong Jong Ju , Nam Kee‐Hyun , Chung Woong Youn 
Published: October 2022

ObjectivesThis study aimed to demonstrate the usefulness of single‐port transaxillary robotic modified radical neck dissection (STAR‐RND) for metastatic thyroid cancer, and its potential to make small and invisible surgical wounds possible compared to open modified radical neck dissection.MethodsBetween January 2020 and July 2021, 30 thyroid cancer patients who underwent lateral neck dissection surgery with the da Vinci SP at Yonsei University Health System (Seoul, Korea) were studied.ResultsAll 30 patients, diagnosed with papillary thyroid cancer were women. The average operating time was 293.80 ± 36.58 (min), and the average postoperative hospital stay was 4.77 ± 0.57 (days). All patients were discharged after the expected number of hospitalization days without major complications.ConclusionSTAR‐RND is technically feasible and safe with a short length of the incision. To our knowledge, this is the first report on the use of a single‐port robotic system for modified radical neck dissection.Level of Evidence by Using 2011 OCEBM4 Laryngoscope, 133:709–714, 2023
Clinical and mycological investigations of post‐COVID‐19 acute invasive fungal sinusitis
Authors: Eldsouky Samah Mahmoud , Shahat Amany K. , AL‐Tabbakh AL‐Shaimaa M. , El Rahman Shaymaa M. Abd , Marei Yasmin M. , Mohammed Lina Abdelhady , El‐Shimi Ola Samir , Abdelmotaleb Dina Saad , Marei Yomna Mohammed , Elsayed Mohamed Sabry Abd Elraheam 
Published: October 2022

AbstractObjectivesAn increased incidence of acute invasive fungal sinusitis associated with the recent COVID‐19 pandemic has been observed, which is considered a public health concern. This study aims to detect the incidence, risk factors, causative agents, clinical presentations, outcomes, and susceptibility rate of various antifungals.MethodsIn this cross‐sectional cohort study, a total of 30 patients showing acute invasive fungal rhinosinusitis following a COVID‐19 infection were investigated. Histopathological biopsies, culture identification, and molecular confirmation of the causative agents were conducted. The demographic data, risk factors, clinical presentations, treatment regimen and its outcomes, and efficacy of antifungals were listed and analyzed.ResultsA total of 30 cases with a mean age of 59.6 ± 11.9 years were included. Diabetes mellitus was the most recorded comorbidity with a rate of 86.7%, whereas most of the patients received corticosteroids. The mycological examination confirmed the existence of Mucor (Rhizopus oryzae) and Aspergillus (Aspergillus niger) in 96.7% and 3.3% of the cases, respectively. Various stages of sinonasal involvement (ethmoid, maxillary, sphenoid, and inferior turbinate) represented 100%, 83.3%, 66.7%, and 86.7% of the cases, respectively. Headache and facial pain, ophthalmoplegia, visual loss, and blindness represented 100%, 66.7%, 90%, and 53.3% of the cases, respectively. All the cases were simultaneously treated with surgical debridement and amphotericin B. Moreover, R. oryzae was susceptible to it, whereas A. niger was sensitive to voriconazole, resulting in a survival rate of 86.7% (26/30). The R. oryzae and A. niger isolates were proven to be sensitive to acetic acid, ethyl alcohol, formalin, and isopropyl alcohol.ConclusionsIn patients with COVID‐19, the diagnosis of acute invasive fungal sinusitis and prompt treatment with antifungal medicine and surgical debridement are important in achieving better outcomes and survival rates.Level of Evidence4
Synthetic‐to‐real domain adaptation with deep learning for fitting the intravoxel incoherent motion model of diffusion‐weighted imaging
Authors: Huang Haoyuan , Liu Baoer , Xu Yikai , Zhou Wu 
Published: October 2022

AbstractBackgroundIntravoxel incoherent motion (IVIM) is a type of diffusion‐weighted imaging (DWI), and IVIM model parameters (water molecule diffusion rate Dt, pseudo‐diffusion coefficient Dp, and tissue perfusion fraction Fp) have been widely used in the diagnosis and characterization of malignant lesions.PurposeThis study proposes a deep‐learning model with synthetic‐to‐real domain adaptation to fit the IVIM model parameters of DWI.MethodsNinety‐eight consecutive patients diagnosed with hepatocellular carcinoma between January 2017 and September 2020 were included in the study, and routine IVIM–DWI serial examinations were performed using a 3.0 T magnetic resonance imaging system in preoperative MR imaging. The proposed method is mainly composed of two modules: a convolutional neural network–based IVIM model fitting network to map b‐value images to the IVIM parameter maps and a domain discriminator to improve the accuracy of the IVIM parameter maps in the real data. The proposed method was compared with previously reported fitting methods, including the nonlinear least squares (NLSs), IVIM‐NEToptim, and self‐supervised U‐network methods. The IVIM parameter‐fitting performance was assessed by measuring the DWI reconstruction performance and testing the robustness of each method against noise using noise‐corrupted data.ResultsThe DWI reconstruction performance demonstrates that the proposed method has better reconstruction accuracy for DWI with a low signal‐to‐noise ratio, which implies that the proposed method improves the fitting accuracy of the IVIM parameters. Noise‐corrupt experiments show that the proposed method is more robust against noise‐corrupted signals. With the proposed method, no outliers were found in Dt, and outliers were reduced for Fp in the abnormal regions (proposed method: 1.85%; NLS: 5.90%; IVIM‐NEToptim: 6.61%; and self‐U‐net: 25.36%). Moreover, experiments show that the proposed method has a more stable parameter estimation performance than the existing methods in the absence of real data.ConclusionsIVIM parameters can be estimated using a synthetic‐to‐real domain‐adaptation framework with deep learning, and the proposed method outperforms previously reported methods.
A simple Eulerian–Lagrangian weakly compressible smoothed particle hydrodynamics method for fluid flow and heat transfer
Authors: Yoo Hee Sang , Jo Young Beom , Kim Jin Woo , Kim Eung Soo , Choi Tae Soo 
Published: October 2022

AbstractIn this article, we propose a simple, consistent, and robust Eulerian–Lagrangian weakly compressible smoothed particle hydrodynamics (EL‐WCSPH) for the simulation of hydrodynamics and convection heat transfer problems. First, the basic governing equation is formulated using the ALE‐SPH framework. The universal formulation is similar to the standard WCSPH, but the degree of Eulerian and Lagrangian schemes can be controlled by inserting a pre‐defined arbitrary parameter . To alleviate potential numerical errors and inconsistency, particle mass correction is proposed along with particle disorder correction. Then, an algorithm is introduced, in which only a slight modification is necessary compared to the standard WCSPH. Finally, extensive benchmark simulations are conducted to validate the proposed method. As a result, the proposed method is found to perform well in hydrodynamics problems with various flow conditions (pipe flow, lid‐driven problem, Taylor–Green vortex, vortex shedding problem, and water sloshing) and thermal‐hydraulics problems (natural convection in a square cavity).
Computation of eigenvalues of a real, symmetric 3 × 3 matrix with particular reference to the pernicious case of two nearly equal eigenvalues
Authors: Harari Isaac , Albocher Uri 
Published: October 2022

AbstractStandard, closed‐form solutions for eigenvalues of symmetric, real‐valued matrices are susceptible to loss of significance in floating point computation in the case of two nearly equal eigenvalues. The non‐negative discriminant of the cubic characteristic polynomial vanishes as these two eigenvalues merge. Turning points of the cubic curve reveal two non‐negative invariant factors of the discriminant. These factors are defined in the favorable form of sums of squares by the Cayley–Hamilton theorem, to be used as numerically stable invariants instead of the determinant. Full numerical stability of the procedure is attained by expressing the angular coordinate in terms of the tangent function rather than the cosine, enhanced by range reduction obtained by considering the half angle. This approach combines robust performance in floating point computation with run times that are on par with conventional schemes.
Radiation‐sensitive nanogel‐incorporated Fricke hydrogel dosimeters with reduced diffusion rates
Authors: Wang Kaikai , Zhang Wei , Qi Yameng , Hu Xiaodan , Zhang Xiaohong , Chang Shuquan , Zhang Haiqian 
Published: October 2022

AbstractFricke gel dosimeters have great potential for three‐dimensional (3D) dose verification in radiation therapy; however, they suffer from time‐dependent ion diffusion after irradiation, severely affecting their stability and reliability. In this work, a pullulan‐based amphiphilic molecule was synthesized, characterized, and self‐assembled into nanogels. Nanogel structures were embedded into gel dosimeters to reduce the diffusion rates, and radiation‐sensitive nanogel‐incorporated Fricke hydrogel nanocomposites were prepared successfully. The results demonstrated that the diffusion coefficient of improved dosimeters was reduced to 0.125 ± 0.001 mm2 h−1, while maintaining the high optical dose sensitivity (0.0410 ± 0.0004 Gy−1 cm−1). It provides a powerful tool toward the practical application of 3D dosimeters.
“The simple life experiences that every other human gets”: Desire for normalcy among adolescents and young adults with advanced cancer
Authors: Umaretiya Puja J. , Fisher Lauren , Altschuler Andrea , Kushi Lawrence H. , Chao Chun R. , Vega Brenda , Rodrigues Gilda , Josephs Isabel , Brock Katharine E. , Buchanan Susan , Casperson Mallory , Fasciano Karen M. , Kolevska Tatjana , Lakin Joshua R. , Lefebvre Anna , Schwartz Corey M. , Shalman Dov M. , Wall Catherine B. , Wiener Lori , Bona Kira , Mack Jennifer W. 
Published: October 2022

AbstractBackgroundAdolescents and young adults (AYAs) with advanced cancer identify normalcy as an important component of quality end‐of‐life care. We sought to define domains of normalcy and identify ways in which clinicians facilitate or hinder normalcy during advanced cancer care.ProcedureThis was a secondary analysis of a qualitative study that aimed to identify priority domains for end‐of‐life care. Content analysis of semi‐structured interviews among AYAs aged 12–39 years with advanced cancer, caregivers, and clinicians was used to evaluate transcripts. Coded excerpts were reviewed to identify themes related to normalcy.ResultsParticipants included 23 AYAs with advanced cancer, 28 caregivers, and 29 clinicians. Participants identified five domains of normalcy including relationships, activities, career/school, milestones, and appearance. AYAs and caregivers identified that clinicians facilitate normalcy through exploration of these domains with AYAs, allowing flexibility in care plans, identification of short‐term and long‐term goals across normalcy domains, and recognizing losses of normalcy that occur during cancer care.ConclusionsAYAs with cancer experience multiple threats to normalcy during advanced cancer care. Clinicians can attend to normalcy and improve AYA quality of life by acknowledging these losses through ongoing discussions on how best to support domains of normalcy and by reinforcing AYA identities beyond a cancer diagnosis.
Role of regional anesthesia in patients with acute sickle cell pain: A scoping review
Authors: Rizvi Munaza B. , Kessler David O. , Rabiner Joni E. 
Published: October 2022

AbstractSickle cell disease is the most prevalent inherited blood disorder in the world, with significant morbidity and mortality. Patients often have recurrent painful vaso‐occlusive episodes, and the American Society of Hematology gives a conditional recommendation for the use of regional anesthesia for acute sickle cell pain management. This scoping review summarizes the current evidence and identifies gaps for future research. Our screening process is outlined, and articles that mentioned the use of regional anesthesia for acute sickle cell crises were included. We present and interpret our results and highlight opportunities for future investigation.
A retrospective investigation of the relationship between neuroblastoma response to anti‐GD2 monoclonal antibodies and exposure to opioids for pain management
Authors: Morgan Kyle J. , Dudas Andrew , Furman Wayne L. , McCarville M. Beth , Shulkin Barry L. , Lu Zhaohua , Darji Himani , Anghelescu Doralina L. 
Published: October 2022

AbstractObjectiveRecent increased awareness and research studies reflect possible associations between opioid exposure and cancer outcomes. Children with neuroblastoma (NB) often require opioid treatment for pain. However, associations between tumor response to chemotherapy and opioid exposure have not been investigated in clinical settings.MethodsThis is a single‐institution retrospective review of patients with NB treated between 2013 and 2016. We evaluated opioid consumption quantified in morphine equivalent doses (mg/kg) based on nurse‐ or patient‐controlled analgesia during antibody infusions. We also analyzed their associations with change in primary tumor volume and total tumor burden.ResultsOf 42 patients given opioids for pain related to anti‐disialoganglioside monoclonal antibodies (anti‐GD2 mAb), data completion was achieved for 36, and details of statistical analyses were entered. Median total weight‐based morphine equivalent (over 8 days) was 4.71 mg/kg (interquartile range 3.49–7.96). We found a statistically insignificant weak negative relationship between total weight‐based morphine equivalents and tumor volume ratio (correlation coefficient −.0103, p‐value .9525) and a statistically insignificant weak positive relationship between total weight‐based morphine equivalent and Curie score ratio (correlation coefficient .1096, p‐value .5247).ConclusionOur study found no statistically significant correlation between opioid consumption and natural killer (NK) cell‐mediated killing of NB cells as measured by effects on tumor volume/tumor load.
Prenatal diagnosis of fetal ectopia cordis by fetal cardiovascular magnetic resonance imaging
Authors: Liu Ke , Zhu Ming , Dong Su‐Zhen 
Published: October 2022

AbstractObjectiveThe purpose of this retrospective study was to report our cases of fetal ectopia cordis (EC) and to evaluate the utility of fetal cardiovascular magnetic resonance imaging (MRI) for the diagnosis of this rare anomaly.MethodThis retrospective study included 11 fetuses with EC. The multiplane steady‐state free precession (SSFP) sequence, single‐shot turbo spin‐echo sequence and non‐gated SSFP cine cardiovascular magnetic resonance were used to evaluate the fetal heart and abdomen.ResultsThe 11 fetal cases with EC were examined by fetal cardiovascular MRI and confirmed by postnatal or post‐mortem findings. Of these 11 cases, two were isolated thoracic EC, six had pentalogy of Cantrell, and three had an omphalocele and EC. Among all 11 fetuses, nine were associated with congenital heart defects. In four cases, fetal MRI added additional information compared to fetal ultrasound, however, in two cases, fetal MRI missed the diagnosis of a ventricular septal defect noted by echocardiography.ConclusionFetal MRI combined with prenatal echocardiography can improve the accuracy of the prenatal diagnosis of EC.
Composite films with low dielectric constant and dielectric loss factor at high frequency prepared from polyimide and polytetrafluoroethylene
Authors: Zhang Wang , Jiang Hanzhou , Nie Yong , Fang Xingzhong , Chen Guofei 
Published: October 2022

AbstractA series of polyimide/polytetrafluoroethylene (PI/PTFE) hybrid films were synthesized by blending water‐soluble polyamide acid salts with water‐based PTFE dispersion and thermal imidization to enhance the dielectric proprieties of PI. The relationship between PTFE filler content and the properties of films has been investigated. The results showed that the dielectric properties of PI were effectively improved by PTFE fillers and all films showed excellent heat resistance. When the addition of PTFE filler was 30 wt%, the PI and PTFE in PI/PTFE‐30 hybrid film still showed good compatibility and dispersity. The dielectric constant and dielectric loss factor were decreased to 2.42 and 0.0044 at 10 GHz, respectively. Meanwhile, the film PI/PTFE‐30 had the lowest water absorption (0.11%) and maximum water contact angle (95.3°).
Aromaticity of the triplet states of corannulene and coronene
Authors: Govorov Dmitrii , Pitawela Niroodha R. , Gudmundsdottir Anna D. 
Published: October 2022

AbstractSunlight‐driven photochemical reactions are an important tool for sustainable organic synthesis. However, compared with ground states, for which the effects of structure on properties and reactivity are well established, the understanding of excited states is limited. In particular, an improved understanding of aromaticity and antiaromaticity in excited states is necessary to develop strategic photochemical methods for synthesizing polycyclic aromatic compounds. Herein, using density functional theory (DFT)‐optimized structures, the ground singlet (S0) and lowest triplet (T1) states of coronene and corannulene were compared. Bond length analysis demonstrated that both triplet corannulene and triplet coronene bear a partial resemblance to benzene. Nucleus‐independent chemical shift (NICS(0), NICS(1.7)ZZ, NICS scans) and anisotropy of the induced current density (ACID) calculations were carried out to compare the induced magnetic currents in these molecules. This analysis demonstrated rather weak π‐conjugation and partial antiaromaticity in the S0 state of each molecule. In contrast, a combination of circular induced currents and pronounced antiaromaticity was found in the T1 state of each molecule. However, the T1 of corannulene exhibited higher stability, which should facilitate functionalization. Consequently, corannulene is considered more suitable for photochemical applications.
Quality of life of long‐term childhood acute lymphoblastic leukemia survivors: Comparison with healthy controls
Authors: Chantziara Sofia , Musoro Jammbe , Rowsell Alison C. , Sleurs Charlotte , Coens Corneel , Pe Madeline , Suciu Stefan , Kicinski Michal , Missotten Pierre , Vandecruys Els , Uyttebroeck Anne , Dresse Marie‐Françoise , Pluchart Claire , Ferster Alina , Freycon Claire , Bosch Jutte Van Der Werff ten , Rohrlich Pierre , Benoit Yves , Darlington Anne‐Sophie , Piette Caroline ,   European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QLG) and Children's Leukemia Group (CLG)
Published: October 2022

AbstractObjectiveImproved treatment landscape has led to better outcomes for paediatric acute lymphoblastic leukemia (ALL) survivors. As the number of survivors increase, we need to elucidate the long‐term quality of life (QoL) and domains of complaints in these patients. Furthermore, the main priorities of these patients need to be clarified. We assessed long‐term QoL outcomes of survivors of childhood ALL compared to matched population controls.MethodsQoL data were collected from survivors recruited in France and Belgium between 2012 and 2017, including the Short Form Health Survey (SF‐12) and the Quality of Life Systemic Inventory (QLSI). The Wilcoxon test was used to compare SF‐12 scale scores between survivors and matched population controls. For the QLSI, comparisons were mainly descriptive.ResultsOne hundred and eighty‐six survivors (mean age: 27.6 years; range: 18.1–52.8) at follow‐up completed QoL measures, amongst whom 180 were matched to controls. Overall, survivors had higher QoL on all SF12 scale scores, indicating that they had better functioning compared to controls. Statistically significant differences on the SF12 were observed for Vitality, Social Functioning, Role Limitations due to Emotional Problems and Mental Health scales. QLSI outcomes suggested that survivors were happier than controls with Couple and Social Relations. Controls were unhappiest compared to survivors with Money, Love life, Self‐esteem, Nutrition and Paid Work.ConclusionsOur findings suggest that survivors of childhood ALL have better QoL outcomes on some domains compared to the general population, specifically around social and emotional functioning, and that they tend to prioritize their relationships more. Interventions for improving QoL outcomes, might build on existing positive experiences with family, friends and partners.
Seed germination responses to temperature and water availability in weedy rice
Authors: Fukuda Monrawee , Imaizumi Toshiyuki , Koarai Akira 
Published: October 2022

AbstractBACKGROUNDWeedy rice is one of the main agricultural weeds infesting transplanted and direct‐seeded rice cultures across Japan. However, the environmental factors that facilitate its proliferation are largely unknown. This study investigated the effects of temperature and water availability on seed germination of Japanese weedy and cultivated rice strains differing in degree of seed dormancy and after‐ripening. This information could help predict weedy rice infestation and design efficacious control measures.RESULTSThe germination responses of weedy rice to temperature and water availability varied among strains and after‐ripening duration. The germination rate varied inversely with the degree of dormancy, increased with water availability, and fluctuated between low and high temperatures. The shallow‐dormant tropical japonica‐derived strawhull weedy rice (TRJ) germinated at 10 °C unlike the temperate japonica‐derived weedy rice strains, namely, the intermediate‐dormant blackhull (BH) and the deep‐dormant strawhull (SH). Seeds of all plant strains germinated below the permanent wilting point of clay loam soil, but the germination rates were higher for TRJ and BH than for cultivated rice. SH germination was more synchronous with rice than the other weedy rice strains.CONCLUSIONThis study has confirmed the overall robustness of germination cold tolerance at 10 °C in TRJ, high germinability at low‐water availability and high temperature in TRJ and BH, and relatively more synchronous germination between SH and cultivated rice in seeds grown in different years. These observed characteristics are considered advantageous to the coexistence of weedy rice with cultivated rice. © 2022 Society of Chemical Industry.