bluuebunny/crossref_metadata_2025_split huggingface dataset:
Casual selling practice: a qualitative study of non-professional sellers' involvement on C2C social commerce platforms
Authors: Schwob Alexandre , de Kervenoael Ronan , Kirova Valentina , Vo-Thanh Tan 
Published: April 2022

PurposeRecent substantial developments of consumer-to-consumer social commerce platforms (C2C-SCPs) emboldened consumers/users to be involved as sellers. Considering C2C social networks that privilege local reach, this paper aim to explore how the practice-based view informs non-professional sellers' involvement.Design/methodology/approachUnderpinned by data from 29 semi-structured interviews with non-professional sellers on Kaskus, one of the largest local Indonesian C2C-SCPs, the study reveals the emergence of a novel structural practice that we call casual selling.FindingsThe findings show that casual selling allows non-professional sellers' involvement in C2C-SCPs through three broad categories of practices: priming oneself, producing commercial operations and valuing others. Within these three categories, non-professional sellers are found to generate both personal and collective involvement along nine situated market practices.Research limitations/implicationsThis paper adds to previous research by introducing the practice-based view to social commerce literature. In doing so, it deals with the under-investigated seller's perspective and activities that prevail in C2C-SCPs.Originality/valueIn C2C-SCPs, casual selling constitutes a distinct mode of involvement in social commerce in which established professional selling standards are suspended. As a structural practice, it entices non-professional sellers to consider a wider variety of situations in which they are in dialogue with other individuals (buyers and sellers) to shape s-commerce potential. In doing so, C2C-SCP users draw on a dynamic intertwining between digital technology and the socio-cultural environment surrounding s-commerce.
Perceived organizational authenticity in LGBTQ communication: the scale development and initial empirical findings
Authors: Lim Hayoung Sally , Ciszek Erica , Moon Won-Ki 
Published: April 2022

PurposeThe purpose of this study is to develop an integrative concept of perceived authenticity that captures a more nuanced perception of authenticity among LGBTQ stakeholders and to examine the effects of perceived organizational authenticity on Pride campaign evaluations.Design/methodology/approachWith 400 LGBTQ/non-LGBTQ participants, we developed a perceived organizational authenticity (POA) scale - adapted from marketing literature - adding representativeness as the fifth dimension to the context of LGBTQ communication. We also examined the differences between LGBTQ participants and non-LGBTQ participants in perceiving authenticity and evaluating the Pride 2020 campaign in terms of brand attitude, skepticism and purchase intention.FindingsOur scale development resulted in a 20-item POA scale measuring five dimensions: continuity, credibility, integrity, symbolism and representativeness. We also found that POA increases brand attitude and purchase intention while mitigating skepticism toward the Pride 2020 campaign.Research limitations/implicationsThis study provides not only empirical support for perceived authenticity literature across communication disciplines including marketing as well as public relations, but it also propels an interdisciplinary approach to POA scale development.Practical implicationsThe POA scale can be used to measure the effectiveness of organizational communication as well as stakeholder perception of authenticity. This research provides guidelines regarding how POA of LGBTQ communication might be enhanced.Originality/valueThis study developed a POA scale in the context of LGBTQ communication. This study is innovative in developing a POA scale that can be used to measure the effectiveness of public relations and communication efforts, as well as perceived authenticity of LGBTQ communication.
Pilot development: an empirical mixed-method analysis
Authors: Slottje Jonathan , Anderson Jason , Dickens John M. , Reiman Adam D. 
Published: April 2022

PurposePilot upgrade training is critical to aircraft and passenger safety. This study aims to identify variances in the US Air Force C-130J pilot upgrade training based on geographic location and provide a model to enhance policy that will impact future pilot training efforts that lower cost and increase operator quality and proficiency.Design/methodology/approachThis research employed a mixed-method approach. First, the authors collected data and analyzed 90 C-130J pilots' aviation records and then contextualized this analysis with interviews of experts. Finally, the authors present a modified version of Six Sigma's define–measure–analyze–improve–control (DMAIC) that identifies and reduces the variances in C-130J pilot training, translating into higher quality outcomes.FindingsThe results indicate significant statistical variances across geographically separated C-130J pilot training organizations. This leads some organizations to have higher proficiency levels in specific tasks and others with comparative deficiencies. Additionally, the data analysis in this study enabled a recommended number of flight hours in several distinct categories that should be obtained before upgrading a pilot to aircraft commander to enhance standards.Research limitations/implicationsThis research was limited to C-130J pilot upgrades, but these results can be implemented within any field that utilizes hours as a measure of experience. Implications from this research can be employed to scope policy that will influence pilot training requirements across all airframes in civilian and military aviation.Originality/valueThis research proposes a process improvement methodology that could be immediately implemented within the C-130J community and, more importantly, in any upgrade training where humans advance into higher echelons of a profession.
Computer-generated influencers: the rise of digital personalities
Authors: Mrad Mona , Ramadan Zahy , Nasr Lina Issam 
Published: April 2022

PurposeThe purpose of this study is to identify the key components pertaining and governing a Computer-Generated Influencer’s (CGI’s) identity and explores and analyzes the ensuing relationship between the CGI and its digital environment.Design/methodology/approachThis study follows an exploratory approach using in-depth interviews of CGI followers. A total of 37 in-depth interviews were then analyzed using an inductive thematic approach to steer data coding.FindingsCGIs are considered as brand entities that have a combination of components under their overall perceived identity. This study encompasses the different relational dimensions, whether from a follower’s followers, CGI-follower’s, CGI–human influencer’s or CGI-endorsed brand’s perspective.Originality/valueThis research contributes a seminal work in the field of virtual influencers.
Ungual seborrheic keratosis with longitudinal melanonychia: A case report
Authors: Kameda Eisuke , Togawa Yaei , Maru Yugo , Matsue Hiroyuki 
Published: April 2022

AbstractIn this paper, we report the case of a 71‐year‐old man with an 8‐year history of melanonychia on the right little finger, who referred to our hospital because the color of pigmented area had gradually darkened and the width had expanded. Physical examination revealed longitudinal melanonychia with brown color (4 mm in width). Dermoscopic examination revealed multiple white round clods and splinter hemorrhages. No micro‐Hutchinson sign was observed. We performed a punch biopsy (diameter 3 mm) of the nail matrix for diagnosis. Histopathological examination revealed irregular acanthosis of epithelium of the nail bed and distal matrix, which consisted of basaloid cells without nuclear atypia. Several zones exhibited cell whorls reminiscent of squamous eddies. The whorls were composed of large pink cells arranged in an onion peel‐like fashion. The basaloid cells tested negative for human papillomavirus in situ hybridization and p16 staining. The morphology of white round clods (milia‐like cysts in metaphoric term) observed in dermoscopic analysis corresponded to squamous eddies in histopathology. Considering these features, ungual seborrheic keratosis (SK) with longitudinal melanonychia was diagnosed, which is an atypical site for SK. We suggest that the dermoscopic finding of milia‐like cysts may be useful for the diagnosis of ungual SK.
Morphological adaptations linked to flight efficiency and aerial lifestyle determine natal dispersal distance in birds
Authors: Weeks Brian C. , O'Brien Bruce K. , Chu Jonathan J. , Claramunt Santiago , Sheard Catherine , Tobias Joseph A. 
Published: April 2022

Abstract

Natal dispersal—the movement from birthplace to breeding location—is often considered the most significant dispersal event in an animal's lifetime. Natal dispersal distances may be shaped by a variety of intrinsic and extrinsic factors, and remain poorly quantified in most groups, highlighting the need for indices that capture variation in dispersal among species.

In birds, it is hypothesized that dispersal distance can be predicted by flight efficiency, which can be estimated using wing morphology. However, the use of morphological indices to predict dispersal remains contentious and the mechanistic links between flight efficiency and natal dispersal are unclear.

Here, we use phylogenetic comparative models to test whether hand‐wing index (HWI, a morphological proxy for wing aspect ratio) predicts natal dispersal distance across a global sample of 114 bird species. In addition, we assess whether HWI is correlated with flight usage in foraging and daily routines.

We find that HWI is a strong predictor of both natal dispersal distance and a more aerial lifestyle.

Our results support the use of HWI as a valid proxy for relative natal dispersal distance, and also suggest that evolutionary adaptation to aerial lifestyles is a major factor connecting flight efficiency with patterns of natal dispersal.

Read the free Plain Language Summary for this article on the Journal blog.
Shift in harms and benefits of cervical cancer screening in the era of HPV screening and vaccination: a modelling study
Authors: Kaljouw Sylvia , Jansen Erik E. L. , Aitken Clare A. , de Kok Inge M. C. M. 
Published: April 2022

AbstractObjectiveTo calculate the changes in harms and benefits of cervical cancer screening over the first three screening rounds of the Dutch high‐risk human papillomavirus (hrHPV) screening programme.DesignMicrosimulation study.SettingDutch hrHPV screening programme; women are invited for screening every 5 or 10 years (depending on age and screening history) from age 30 to 65.PopulationPartly vaccinated population of 100 million Dutch women.MethodsMicrosimulation model MISCAN was used to estimate screening effects. Sensitivity analyses were performed on test characteristics and attendance.Main outcome measuresHarms (screening tests, unnecessary referrals, treatment‐related health problems), benefits (CIN2+ diagnoses) and programme efficiency (number needed to screen [NNS]) over the first (period 2017–2021), second (period 2022–2026) and third (period 2027–2031) rounds of hrHPV‐based screening.ResultsThe number of screening tests and CIN2+ diagnoses decreased from the first to the second round (−25.8% and −23.6%, respectively). In the third screening round, these numbers decreased further, albeit only slightly (−2.7% and −5.3%, respectively). NNS to detect a CIN2+ remained constant over the rounds; however, it increased in younger age groups while decreasing in older age groups.ConclusionBoth harms and benefits of hrHPV screening decreased over the first screening rounds. For younger women, the efficiency would decrease, whereas longer screening intervals would lead to increased efficiency in older women. Programme efficiency overall remained stable, showing the importance of longer intervals for low‐risk women.Tweetable abstract:Cervical cancer screening: both harms and benefits of hrHPV screening will decrease in the future.
An ancient truncated duplication of the anti‐Müllerian hormone receptor type 2 gene is a potential conserved master sex determinant in the Pangasiidae catfish family
Authors: Wen Ming , Pan Qiaowei , Jouanno Elodie , Montfort Jerome , Zahm Margot , Cabau Cédric , Klopp Christophe , Iampietro Carole , Roques Céline , Bouchez Olivier , Castinel Adrien , Donnadieu Cécile , Parrinello Hugues , Poncet Charles , Belmonte Elodie , Gautier Véronique , Avarre Jean‐Christophe , Dugue Remi , Gustiano Rudhy , Hà Trần Thị Thúy , Campet Marc , Sriphairoj Kednapat , Ribolli Josiane , de Almeida Fernanda L. , Desvignes Thomas , Postlethwait John H. , Bucao Christabel Floi , Robinson‐Rechavi Marc , Bobe Julien , Herpin Amaury , Guiguen Yann 
Published: April 2022

AbstractThe evolution of sex determination (SD) in teleosts is amazingly dynamic, as reflected by the variety of different master sex‐determining genes identified. Pangasiids are economically important catfishes in South Asian countries, but little is known about their SD system. Here, we generated novel genomic resources for 12 Pangasiids and characterized their SD system. Based on a Pangasianodon hypophthalmus chromosome‐scale genome assembly, we identified an anti‐Müllerian hormone receptor type Ⅱ gene (amhr2) duplication, which was further characterized as being sex‐linked in males and expressed only in testes. These results point to a Y chromosome male‐specific duplication (amhr2by) of the autosomal amhr2a. Sequence annotation revealed that the P. hypophthalmus Amhr2by is truncated in its N‐terminal domain, lacking the cysteine‐rich extracellular part of the receptor that is crucial for ligand binding, suggesting a potential route for its neofunctionalization. Reference‐guided assembly of 11 additional Pangasiids, along with sex‐linkage studies, revealed that this truncated amhr2by duplication is a male‐specific conserved gene in Pangasiids. Reconstructions of the amhr2 phylogeny suggested that amhr2by arose from an ancient duplication/insertion event at the root of the Siluroidei radiation that is dated to ~100 million years ago. Together these results bring multiple lines of evidence supporting that amhr2by is an ancient and conserved master sex‐determining gene in Pangasiids, a finding that highlights the recurrent use of the transforming growth factor β pathway, which is often used for the recruitment of teleost master SD genes, and provides another empirical case towards firther understanding of dynamics of SD systems.
Increased activation of cGAS‐STING pathway enhances radiosensitivity of non‐small cell lung cancer cells
Authors: Xue Aiying , Shang Yue , Jiao Peng , Zhang Songling , Zhu Changchun , He Xin , Feng Guoxing , Fan Saijun 
Published: April 2022

AbstractBackgroundRadiotherapy is an effective therapeutic approach widely used clinically in non‐small cell lung cancer (NSCLC), but radioresistance remains a major challenge. New and effective radiosensitizing approaches are thus urgently needed. The activation of DNA‐sensing cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) pathway has become an attractive therapeutic target, but the relationship between activation of cGAS‐STING pathway and radiosensitization of NSCLC cells remains unknown.MethodsConsidering low expression of cGAS‐STING pathway genes in NSCLC, including STING, we used an activator (STING agonist, dimeric amidobenzimidazole [diABZI]) of cGAS‐STING pathway and increased activation factor (DNA double strand breaks) of cGAS‐STING pathway to respectively reinforce the activation of cGAS‐STING pathway in NSCLC cells. We then investigated the effect of increased activation of cGAS‐STING pathway on the proliferation of H460 and A549 cells by CCK‐8 and colony formation assays, and revealed the underlying mechanism.ResultsWe found that both diABZI and the increased DNA double strand breaks could sensitize NSCLC cells to irradiation. Mechanically, our results showed that the increased activation of cGAS‐STING pathway enhanced radiosensitivity by promoting apoptosis in NSCLC cells.ConclusionTaken together, we concluded that diABZI could be used as a radiosensitizer in NSCLC cells, and targeting the activation of cGAS‐STING pathway has a potential to be a new approach for NSCLC radiosensitizing.
Mubritinib enhanced the inhibiting function of cisplatin in lung cancer by interfering with mitochondrial function
Authors: Dong Jingyao , Zhu Dongshan , Chen Mengmeng , Wang Taiwei , Gao Yan , Liu Wei 
Published: April 2022

AbstractBackgroundLung cancer is one of the most lethal cancers worldwide. Cisplatin, a widely used anti‐lung cancer drug, has been limited in clinical application due to its drug resistance. Medicines targeting mitochondrial electron transport chain (ETC) complexes may be effective candidates for cisplatin‐based chemotherapy.MethodsIn this study, the small molecule drug library from Food and Drug Administration FDA was used to screen for medicines targeting ETC. MTT and colony formation assays were used to investigate cell proliferation. Flow cytometry was employed to analyze cell cycle, apoptosis, reactive oxygen species (ROS), and mitochondrial membrane potential. Wound scratch and transwell assays were used to detect migration and invasion abilities. The activities of the ETC complex were tested using kits. Western blot analysis was used to investigate the expressions of related proteins. A mouse xenograft model was constructed to verify the antitumor effect in vivo.ResultsThe results showed that mubritinib can reduce the activation of the PI3K/mTOR signal pathway, disrupt mitochondrial function, significantly increase ROS levels and induce oxidative stress, and ultimately exert its antitumor effect against non‐small cell lung cancer (NSCLC) both in vivo and in vitro. In addition, the combination of cisplatin and mubritinib can improve the tumor‐suppressive effect of cisplatin.ConclusionMubritinib can upregulate intracellular ROS concentration and cell apoptosis, inhibit the PI3K signaling pathway and interfere with the function of mitochondria, thus reducing cell proliferation and increasing ROS induced apoptosis by reducing the activation of Nrf2 by PI3K.
COVID‐19 patients with documented alcohol use disorder or alcohol‐related complications are more likely to be hospitalized and have higher all‐cause mortality
Authors: Bailey Kristina L. , Sayles Harlan , Campbell James , Khalid Neha , Anglim Madyson , Ponce Jana , Wyatt Todd A. , McClay James C. , Burnham Ellen L. , Anzalone Alfred , Hanson Corrine 
Published: April 2022

AbstractBackgroundCoronavirus Disease 2019 (COVID‐19) has affected every country globally, with hundreds of millions of people infected with the SARS‐CoV‐2 virus and over 6 million deaths to date. It is unknown how alcohol use disorder (AUD) affects the severity and mortality of COVID‐19. AUD is known to increase the severity and mortality of bacterial pneumonia and the risk of developing acute respiratory distress syndrome. Our objective is to determine whether individuals with AUD have increased severity and mortality from COVID‐19.MethodsWe utilized a retrospective cohort study of inpatients and outpatients from 44 centers participating in the National COVID Cohort Collaborative. All were adult COVID‐19 patients with and without documented AUDs.ResultsWe identified 25,583 COVID‐19 patients with an AUD and 1,309,445 without. In unadjusted comparisons, those with AUD had higher odds of hospitalization (odds ratio [OR] 2.00, 95% confidence interval [CI] 1.94 to 2.06, p < 0.001). After adjustment for age, sex, race/ethnicity, smoking, body mass index, and comorbidities, individuals with an AUD still had higher odds of requiring hospitalization (adjusted OR [aOR] 1.51, CI 1.46 to 1.56, p < 0.001). In unadjusted comparisons, individuals with AUD had higher odds of all‐cause mortality (OR 2.18, CI 2.05 to 2.31, p < 0.001). After adjustment as above, individuals with an AUD still had higher odds of all‐cause mortality (aOR 1.55, CI 1.46 to 1.65, p < 0.001).ConclusionThis work suggests that AUD can increase the severity and mortality of COVID‐19 infection. This reinforces the need for clinicians to obtain an accurate alcohol history from patients hospitalized with COVID‐19. For this study, our results are limited by an inability to quantify the daily drinking habits of the participants. Studies are needed to determine the mechanisms by which AUD increases the severity and mortality of COVID‐19.
What is the optimum thiamine dose to treat or prevent Wernicke's encephalopathy or Wernicke–Korsakoff syndrome? Results of a randomized controlled trial
Authors: Dingwall Kylie M. , Delima Jennifer F. , Binks Paula , Batey Robert , Bowden Stephen C. 
Published: April 2022

AbstractBackgroundThe primary cause of Wernicke–Korsakoff syndrome (WKS) is thiamine deficiency, and more than 90% of cases are reported in alcohol‐dependent patients. While observational studies show parenteral thiamine administration drastically reduced WKS‐related mortality, relevant treatment trials have never been conducted to determine the optimum thiamine dose.MethodsTwo double‐blind, parallel groups, randomized controlled trials (RCTs) were conducted to determine the optimal thiamine dose required for (1) the prevention of Wernicke's encephalopathy (WE), the acute phase of WKS, in asymptomatic but “at‐risk” alcohol misuse patients (Study 1) and (2) the treatment of WE in symptomatic alcohol misuse patients (Study 2). Each study had a dosage regimen comprising three parenteral thiamine doses that were allocated at a ratio of 1:1:1. Study 1: Asymptomatic At‐Risk patients (N = 393) received either 100 mg daily, 100 mg thrice daily, or 300 mg thrice daily, for 3 days. Study 2: Symptomatic patients (N = 127) received either 100 mg thrice daily, 300 mg thrice daily, or 500 mg thrice daily, for 5 days. Cognitive function was the primary outcome, assessed using the Rowland Universal Dementia Assessment Scale, two Cogstate subtests, and an adapted Story Memory Recall test. Secondary analyses examined differences in neurological function (ataxia, oculomotor abnormalities, and confusion) at follow‐up.ResultsNo significant differences were observed between any of the dosage conditions for either Study 1 or Study 2 on cognition or neurological functioning. This real‐world study found that having a clinically unwell target population with high comorbidity and multiple presentations, coupled with challenges in cross‐cultural assessment is likely to complicate RCT findings.ConclusionsThe results of this study showed no clear benefit of high dose thiamine over intermediate or lower doses of thiamine, over the time intervals examined, for the treatment and prevention of cognitive and neurological abnormalities related to WKS. Several study limitations temper the interpretation of these findings. Nevertheless, the absence of conclusive evidence for the superiority of high‐dose thiamine supports a recommendation for patient‐specific treatment, while ensuring that the potential impact of other biochemical factors (e.g., magnesium and other B vitamin deficiencies) are considered and corrected if necessary.