bluuebunny/crossref_metadata_2025_split huggingface dataset:
External validity of the benign and malicious envy scale with Japanese undergraduate student and non-student samples
Authors: Inoue Yumi , Yokota Kunihiro 
Published: April 2022

AbstractThis study examined the validity of the Japanese version of the Benign and Malicious Envy Scale (BeMaS) with Japanese undergraduate student and non-student samples. Previous studies have identified two types of envy, benign and malicious, that motivate different types of behavior. However, the validity of the BeMaS, developed to measure two types of dispositional envy, has not been adequately confirmed in East Asian countries. Furthermore, it is unclear whether the two-factor structure of BeMaS is identical across various samples. Thus, in this study, we specified the Japanese words describing envy, namely, urayamashii or netamashii, suitable for the Japanese BeMaS. Additionally, we tested the validity of the scale’s two-factor model across undergraduate students and non-student samples. The questionnaire survey results showed that the validity of BeMaS’s two-factor structural model was confirmed in both samples and the goodness of fit was better for urayamashii than for netamashii. Moreover, measurement invariance across the two samples was established in configural and metric models.
Tannery wastewater treatment: conventional and promising processes, an updated 20-year review
Authors: Zhao Jun , Wu Qinglian , Tang Yuling , Zhou Jianfei , Guo Hongguang 
Published: April 2022

AbstractMismanagement of various wastes especially waste water produced by tanning processes has caused serious environmental problems and ultimately impaired human health. Constant efforts have been making to alleviate the pollution of tannery wastewater (TWW), yet terminal treatment still takes dominance. In this review, research on TWW treatment from 2000 to 2021 was summarized, and main methods such as coagulation and flocculation, adsorption, biological treatment, membrane filtration, advanced oxidation process were briefly discussed. More detailed introduction was given to the method of electrochemical treatment since it has excellent performance such as environmental friendliness and high efficiency, hence attracting more and more research attention in recent years. In view of the harsh physi-chemical conditions of TWW, integrated or combined treatment methods are accordingly recommended with better performance and multi-function, however comprehensive studies on optimization of methods combination and cost-effectiveness are needed. The certain issues that the residue Cr in treatment sludge and high salinity in effluent still remain were put forward in this work and potential solutions were provided. Moreover, this review proposed the perspective that realizing multi-function, recycling, and intensification should be the developing direction for future TWW treatment. This review is expected to provide a general guide for researchers who aspire to ameliorate TWW pollution problems and understand various methods utilized in this field.
Graphical abstract
Feminist urban living labs and social sustainability: lessons from Sweden
Authors: Wrangsten Caroline , Ferlander Sara , Borgström Sara 
Published: April 2022

AbstractA debate about emerging models of urban living labs (ULLs) 2.0 is taking place in the literature, highlighting the importance of social aspects. The aim of this paper is to examine feminist ULLs as a potential source of social sustainability. This is conducted through a case study of a feminist ULL in Sweden, where girls and young women, together with multiple professional stakeholders, used Minecraft to redesign a public square in their neighbourhood - a marginalised suburban area of Stockholm. Data was collected through participant observations of six experimental labs during 1 year, surveys of the ULL participants, and an analysis of the final Minecraft designs. The empirical findings reveal a process of mutual learning between girls and professional stakeholders, where the girls were viewed as place experts. The findings also reveal that the girls’ visions include a socially sustainable transition of the urban square: from patriarchal to inclusive, from grey to green, and from a transit area to a meeting-place. There were some differences between girls and professional stakeholders. Whereas the professionals tended to emphasise security in their visions, the girls emphasised liveability. Although more research is needed, this paper concludes that feminist ULLs can be a possible source of social sustainability. However, the ULL process must both be inclusive, and at the same time unlock long-term transformation in the physical environment.
Teaching during COVID-19: reflections of early-career science teachers
Authors: Wieselmann Jeanna R. , Crotty Elizabeth A. 
Published: April 2022

AbstractThe unique circumstances of the COVID-19 pandemic required that instruction be shifted online through asynchronous, synchronous, or hybrid models of instruction. This created a need for many K-12 teachers to dramatically rethink how teaching and learning occurred in their classrooms. In this study, we investigate the experiences of early-career science teachers who were in their first year of teaching when the pandemic struck. Using a comparative case study and an analytical framework focused on technology-related leader practices, we explore the unique opportunities for technology-based leadership that emerged for early-career teachers during the pandemic. We posit that the circumstances of the COVID-19 pandemic presented novel opportunities for early-career teachers to assume leadership roles that were embedded within the classroom teaching experience, which created unique opportunities for innovation and leadership in teaching.
Metaplastic breast carcinoma: an overview of the radio-pathologic features in retrospective cohort tertiary hospital
Authors: Alhaidary Amal Abdulwahab , Arabi Haitham , Elessawy Manar , Alkushi Abdulmohsen 
Published: April 2022

Abstract
Background
Metaplastic breast carcinoma (MBC) is a rare type of breast carcinoma. It accounts for 0.2–1% of all invasive breast carcinoma. The aim of this study is to investigate the radiological features of this tumor and correlate them with the pathological findings.

Results
Of the 22 patients with pathology-proven metaplastic cancers, 18 patients (81.82%) presented with a palpable mass. The majority of the mammogram findings were masses with irregular shapes (n = 12, 63.16%) and indistinct margins (n = 11, 57.89%). Similarly, the majority of the ultrasound studies showed masses with irregular shapes (n = 16, 72.73%) and indistinct margins (n = 8, 36.36%). Most of the echopatterns were complex or with heterogeneous textures, each presented in eight cases (36.36%). More than half of the cases had a posterior acoustic enhancement (n = 12, 54.55%). Most of the cases tested negative for estrogen receptors, progesterone receptors and HER2 protein, and they were high-grade tumors with a high proliferative index (Ki-67%) of > 15%.

Conclusion
MBC is a rare and distinct aggressive breast cancer with no definite characteristic imaging compared to other breast cancer. It shows a mass with irregular shape and indistinct margins in both mammogram and ultrasound. Additionally, it reveals posterior acoustic enhancement and rarely contains microcalcifications. The correlation with the pathological findings is crucial for the diagnosis and subsequent appropriate treatment.
Pragmatic considerations and approaches for measuring staff time as an implementation cost in health systems and clinics: key issues and applied examples
Authors: Huebschmann Amy G. , Trinkley Katy E. , Gritz Mark , Glasgow Russell E. 
Published: April 2022

Abstract
Background
As the field of implementation science wrestles with the need for system decision-makers to anticipate the budget impact of implementing new programs, there has been a push to report implementation costs more transparently. For this purpose, the method of time-driven activity-based costing (TDABC) has been heralded as a pragmatic advance. However, a recent TDABC review found that conventional methods for estimating staff time remain resource-intensive and called for simpler alternatives. Our objective was to conceptually compare conventional and emerging TDABC approaches to measuring staff time.

Methods
Our environmental scan of TDABC methods identified several categories of approaches for staff time estimation; across these categories, staff time was converted to cost as a pro-rated fraction of salary/benefits. Conventional approaches used a process map to identify each step of program delivery and estimated the staff time used at each step in one of 3 ways: (a) uniform estimates of time needed for commonly occurring tasks (self-report), (b) retrospective “time diary” (self-report), or (c) periodic direct observation. In contrast, novel semi-automated electronic health record (EHR) approaches “nudge” staff to self-report time for specific process map step(s)—serving as a contemporaneous time diary. Also, novel EHR-based automated approaches include timestamps to track specific steps in a process map. We compared the utility of these TDABC approach categories according to the 5 R’s model that measures domains of interest to system decision-makers: relevance, rapidity, rigor, resources, and replicability, and include two illustrative case examples.

Results
The 3 conventional TDABC staff time estimation methods are highly relevant to settings but have limited rapidity, variable rigor, are rather resource-intensive, and have varying replicability. In contrast to conventional TDABC methods, the semi-automated and automated EHR-based approaches have high rapidity, similar rigor, similar replicability, and are less resource-intensive, but have varying relevance to settings.

Conclusions
This synthesis and evaluation of conventional and emerging methods for staff time estimation by TDABC provides the field of implementation science with options beyond the current approaches. The field remains pressed to innovatively and pragmatically measure costs of program delivery that rate favorably across all of the 5 R’s domains.
High-Dose Treosulfan and Melphalan as Consolidation Therapy Versus Standard Therapy for High-Risk (Metastatic) Ewing Sarcoma
Authors: Koch Raphael , Gelderblom Hans , Haveman Lianne , Brichard Benedicte , Jürgens Heribert , Cyprova Sona , van den Berg Henk , Hassenpflug Wolf , Raciborska Anna , Ek Torben , Baumhoer Daniel , Egerer Gerlinde , Eich Hans Theodor , Renard Marleen , Hauser Peter , Burdach Stefan , Bovee Judith , Bonar Fiona , Reichardt Peter , Kruseova Jarmila , Hardes Jendrik , Kühne Thomas , Kessler Torsten , Collaud Stephane , Bernkopf Marie , Butterfaß-Bahloul Trude , Dhooge Catharina , Bauer Sebastian , Kiss János , Paulussen Michael , Hong Angela , Ranft Andreas , Timmermann Beate , Rascon Jelena , Vieth Volker , Kanerva Jukka , Faldum Andreas , Metzler Markus , Hartmann Wolfgang , Hjorth Lars , Bhadri Vivek , Dirksen Uta 
Published: April 2022

PURPOSE Ewing 2008R3 was conducted in 12 countries and evaluated the effect of treosulfan and melphalan high-dose chemotherapy (TreoMel-HDT) followed by reinfusion of autologous hematopoietic stem cells on event-free survival (EFS) and overall survival in high-risk Ewing sarcoma (EWS). METHODS Phase III, open-label, prospective, multicenter, randomized controlled clinical trial. Eligible patients had disseminated EWS with metastases to bone and/or other sites, excluding patients with only pulmonary metastases. Patients received six cycles of vincristine, ifosfamide, doxorubicin, and etoposide induction and eight cycles of vincristine, actinomycin D, and cyclophosphamide consolidation therapy. Patients were randomly assigned to receive additional TreoMel-HDT or no further treatment (control). The random assignment was stratified by number of bone metastases (1, 2-5, and > 5). The one-sided adaptive-inverse-normal-4-stage-design was changed after the first interim analysis via Müller-Schäfer method. RESULTS Between 2009 and 2018, 109 patients were randomly assigned, and 55 received TreoMel-HDT. With a median follow-up of 3.3 years, there was no significant difference in EFS between TreoMel-HDT and control in the adaptive design (hazard ratio [HR] 0.85; 95% CI, 0.55 to 1.32, intention-to-treat). Three-year EFS was 20.9% (95% CI, 11.5 to 37.9) in TreoMel-HDT and 19.2% (95% CI, 10.8 to 34.4) in control patients. The results were similar in the per-protocol collective. Males treated with TreoMel-HDT had better EFS compared with controls: median 1.0 years (95% CI, 0.8 to 2.2) versus 0.6 years (95% CI, 0.5 to 0.9); P = .035; HR 0.52 (0.28 to 0.97). Patients age < 14 years benefited from TreoMel-HDT with a 3-years EFS of 39.3% (95% CI, 20.4 to 75.8%) versus 9% (95% CI, 2.4 to 34); P = .016; HR 0.40 (0.19 to 0.87). These effects were similar in the per-protocol collective. This observation is supported by comparable results from the nonrandomized trial EE99R3. CONCLUSION In patients with very high-risk EWS, additional TreoMel-HDT was of no benefit for the entire cohort of patients. TreoMel-HDT may be of benefit for children age < 14 years.
Effects of Sevoflurane-Propofol–Balanced Anesthesia on Flash Visual Evoked Potential Monitoring in Spine Surgery: A Randomized Noninferiority Trial
Authors: Ma Jiajia , Xiong Wei , Guo Dongze , Wang Anxin , Qiao Hui , Han Ruquan 
Published: April 2022

BACKGROUND:
Intraoperative flash visual evoked potential (FVEP) can be used to monitor visual function during spine surgery. However, it is limited due to the previous perception of its sensitivity to inhalation anesthesia. We conducted this trial to test the noninferiority of sevoflurane-propofol–balanced anesthesia (BA) versus popular propofol-based total intravenous anesthesia (TIVA) on the amplitude of FVEP during spine surgery.

METHODS:
A total of 60 patients undergoing spine surgery were randomized to receive either sevoflurane-propofol–balanced anesthesia (BA group) or propofol-based total intravenous anesthesia (TIVA group) for anesthesia maintenance. We titrated the propofol plasma concentration to keep the bispectral index (BIS) values between 40 and 50. The primary outcome was the P100-N145 amplitudes of FVEP at 120 minutes after induction of anesthesia. The noninferiority margin (δ) was defined as 10% of the P100-N145 amplitude at 120 minutes after induction in the TIVA group. If the confidence interval (CI) for mean differences of P100-N145 amplitude at 120 minutes after induction between BA and TIVA groups lied above the lower limit of −δ with P < .025, we defined BA group was noninferior to TIVA group.

RESULTS:
Fifty-nine patients were included in the final analysis. The amplitude of P100-N145 at 120 minutes after anesthesia induction in group BA was noninferior to group TIVA (3.8 [1.3] µV vs 3.2 [1.6] µV, −δ = −0.32, mean difference, 0.57, 95% CI, −0.18 to 1.33, P for noninferiority = .015).

CONCLUSIONS:
The effect of 0.5 minimum alveolar concentration (MAC) of sevoflurane-propofol–balanced anesthesia on the P100-N145 amplitude of FVEP was noninferior to that of propofol-based TIVA under comparable BIS range.
Novel Opioid Analgesics for the Development of Transdermal Opioid Patches That Possess Morphine-Like Pharmacological Profiles Rather Than Fentanyl: Possible Opioid Switching Alternatives Among Patch Formula
Authors: Komatsu Akane , Miyano Kanako , Nakayama Daisuke , Mizobuchi Yusuke , Uezono Eiko , Ohshima Kaori , Karasawa Yusuke , Kuroda Yui , Nonaka Miki , Yamaguchi Keisuke , Iseki Masako , Uezono Yasuhito , Hayashida Masakazu 
Published: April 2022

BACKGROUND:
Transdermal fentanyl is widely used in the treatment of severe pain because of convenience, safety, and stable blood concentrations. Nevertheless, patients often develop tolerance to fentanyl, necessitating the use of other opioids; transdermal buprenorphine patch is widely used as an analgesic agent, though available formulation does not provide comparable analgesic effect as transdermal fentanyl patch. Opioids bind to the opioid receptor (OR) to activate both G protein–mediated and β-arrestin–mediated pathways. We synthesized morphine-related compounds with high transdermal absorbability (N1 and N2) and evaluated their OR activities pharmacologically in comparison with fentanyl and morphine.

METHODS:
In cells stably expressing μ-opioid receptor (MOR), δ-opioid receptor (DOR), and κ-opioid receptor (KOR), G protein–mediated pathways were assessed using the CellKey and an intracellular cyclic adenosine monophosphate (cAMP) assay, while β-arrestin–mediated pathways were analyzed with β-arrestin recruitment and receptor internalization assays. Furthermore, analgesic effects were evaluated using a tail-flick test in mice, and the analgesic effect on fentanyl-tolerant mice was evaluated.

RESULTS:
In the CellKey and cAMP assays, both N1 and N2 showed the highest affinity for MOR and acted as full agonists as well as partial agonists for DOR and KOR. In the β-arrestin and internalization assays, only fentanyl acted as a full agonist; N1 and N2 acted as partial agonists of MOR. In the mouse tail-flick test, N1 and N2 showed analgesic effects equivalent to those of fentanyl and morphine. In fentanyl-tolerant mice, fentanyl showed a diminished analgesic effect, whereas N1 and N2 as well as morphine retained their analgesic effects.

CONCLUSIONS:
While N1 and N2 have higher transdermal absorbability than fentanyl, they also have analgesic effects comparable to those of morphine, suggesting that they may be attractive compounds for the development of novel opioid patches for transitioning from fentanyl patches.
Prevalence and Outcomes of Opioid Use Disorder in Pediatric Surgical Patients: A Retrospective Cohort Study
Authors: Alalade Emmanuel , Mpody Christian , Owusu-Bediako Ekua , Tobias Joseph , Nafiu Olubukola O. 
Published: April 2022

BACKGROUND:
Chronic opioid use among adolescents is a leading preventable public health problem in the United States. Consequently, a sizable proportion of surgical patients in this age group may have a comorbid opioid use disorder (OUD). No previously published study has examined the prevalence of OUD and its impact on postoperative morbidity or mortality in the adolescent surgical population. Our objective was to investigate the prevalence of comorbid OUD and its association with surgical outcomes in a US adolescent surgical population. We hypothesized that OUD among adolescent surgical patients is on an upward trajectory and that the presence of OUD is associated with higher risk of postoperative morbidity or mortality.

METHODS:
Using the pediatric health information system, we performed a 1:1 propensity score-matched, retrospective cohort study of adolescents (10–18 years of age) undergoing inpatient surgery between 2004 and 2019. The primary outcome was inpatient mortality. The secondary outcomes were surgical complications and postoperative infection. We also evaluated indicators of resource utilization, including mechanical ventilation, intensive care unit (ICU) admission, and postoperative length of stay (LOS).

RESULTS:
Of 589,098 adolescents, 563 (0.1%) were diagnosed with comorbid OUD (563 were matched on OUD). The prevalence of OUD in adolescents undergoing surgery increased from 0.4 per 1000 cases in 2004 to 1.6 per 1000 cases in 2019, representing an average annual percent change (AAPC) of 9.7% (95% confidence interval [CI], 5.7–13.9; P value < .001). The overall postoperative mortality rate was 0.50% (n = 2941). On univariable analysis, mortality rate was significantly higher in adolescents with comorbid OUD than those without comorbid OUD (3.37% vs 0.50%; P < .001). Among propensity-matched pairs, comorbid OUD diagnosis was associated with an estimated 57% relative increase in the risk of surgical complications (adjusted relative risk [aRR], 1.57; 95% CI, 1.24–2.00; P < .001). The relative risk of postoperative infection was 2-fold higher in adolescents with comorbid OUD than in those without OUD (aRR, 2.02; 95% CI, 1.62–2.51; P < .001). Adolescents with comorbid OUD had an increased risk of ICU admission, mechanical ventilation, and extended postoperative LOS.

CONCLUSIONS:
OUD is becoming increasingly prevalent in adolescents presenting for surgery. Comorbid OUD is an important determinant of surgical complications, postoperative infection, and resource utilization, underscoring the need to consider OUD as a critical, independent risk factor for postsurgical morbidity.
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Management of Progressive Glioblastoma in Adults: Update of the 2014 Guidelines
Authors: Germano Isabelle M. , Johnson Derek R. , Patrick Hayes H. , Goodman Abigail L. , Ziu Mateo , Ormond D. Ryan , Olson Jeffrey J. 
Published: April 2022

BACKGROUND:
The Institute of Medicine best practice recommendation to review guidelines every 5 years is followed by the Congress of Neurological Surgeons Guidelines Committee. The aim of this work was to provide an updated literature review and evidence-based recommendations on the topic of diagnosis and treatment of patients with progressive glioblastoma (pGBM).

OBJECTIVE:
To review the literature published since the last guidelines on pGBM dated 2014, with literature search ending in June 2012.

METHODS:
PubMed, Embase, and Cochrane were searched for the period July 1, 2012, to March 31, 2019, using search terms and search strategies to identify pertinent abstracts. These were then screened using published exclusion/inclusion criteria to identify full-text review articles. Evidence tables were constructed using data derived from full-text reviews and recommendations made from the evidence derived.

RESULTS:
From the total 8786 abstracts identified by the search, 237 full-text articles met inclusion/exclusion criteria and were included in this update. Two new level II recommendations derived from this work. For the diagnosis of patients with GBM, the use of diffusion-weighted images is recommended to be included in the magnetic resonance images with and without contrast used for surveillance to detect pGBM. For the treatment of patients with pGBM, repeat cytoreductive surgery is recommended to improve overall survival. An additional 21 level III recommendations were provided.

CONCLUSION:
Recent published literature provides new recommendations for the diagnosis and treatment of pGBM. The Central Nervous System Guidelines Committee will continue to pursue timely updates to further improve the care of patients with diagnosis.

https://www.cns.org/guidelines/browse-guidelines-detail/guidelines-management-of-progressive-glioblastoma
Resection of Ependymomas Infiltrating the Fourth Ventricular Floor: Anatomosurgical and Stimulation Mapping Techniques
Authors: Sharma Priya , Sefcikova Viktoria , Sanders Brett , Soumpasis Christos , Waraich Manni , Samandouras George 
Published: April 2022

BACKGROUND:
Despite the importance of complete, gross total resection (GTR) of fourth ventricular ependymomas, significant morbidity and/or subtotal resections are reported, particularly when the ventricular floor is infiltrated. Step-by-step technique descriptions are lacking in the literature.

OBJECTIVE:
To describe monitoring and stimulation mapping techniques and surgical nuances in the challenging subgroup of infiltrating fourth ventricular ependymomas by a highly illustrated, step-by-step description. Superimposed outlines of cranial nerve nuclei on the surgical field demonstrate critical anatomy and facilitate understanding in a way not previously presented.

METHODS:
We reviewed the microanatomical and neurophysiological prerequisites of resecting a diffusively infiltrating fourth ventricular ependymoma.

RESULTS:
We achieved GTR with the use of reproducible stimulating mapping and accurate cranial nerve nuclei identification.

CONCLUSION:
Enhanced microanatomical understanding, reproducible stimulation mapping, and meticulous resection techniques can result in GTR, even in diffusively infiltrating ependymomas.