bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombolysis in central retinal artery occlusion: a retrospective observational study
Authors: Raber Florian Philipp , Gmeiner Florian Vincent , Dreyhaupt Jens , Wolf Armin , Ludolph Albert Christian , Werner Jens Ulrich , Kassubek Jan , Althaus Katharina 
Published: October 2022

Abstract
Background
There is no evidence-based therapy for non-arteritic central retinal artery occlusion (NA-CRAO). Intravenous thrombolysis (IVT) with alteplase in a time window < 4.5 h may lead to a favorable outcome. Purpose of this study was to investigate the feasibility, efficacy and safety of IVT in patients classified as functionally blind.

Methods
We conducted a retrospective observational study of NA-CRAO-patients. All patients underwent an ophthalmological and neurological examination including cerebral magnetic resonance imaging (MRI) for assessment of additional stroke lesions. Patients were treated either conservatively or with IVT within 4.5 h. Visual acuity (VA) was evaluated in logMAR and a categorical analysis was performed.

Results
Thirty-seven patients were included in the study, 21 patients in the conservative treatment group (CTG) and 16 patients in the IVT group. The median logMAR visual acuity at admission and discharge was similar in both groups. The medium symptom to treatment time in the IVT group was 158.0 min. 3 patients (19%) of the IVT group showed a favorable outcome, all CTG patients remained at the level of functional blindness. No serious adverse events were observed after IVT. MRI showed additional acute stroke in over one-third of the patients (n = 14).

Conclusions
Early intravenous thrombolysis therapy according to the current stroke protocol n a time window up to 4.5 h after the onset of symptoms was feasible and might be a potential treatment option for NA-CRAO. Patients with NA-CRAO are at very high risk of ischemic stroke and MRI should be done in all patients for optimized treatment and secondary stroke prevention. A prospective randomized study is required.
A single-center experience with linear accelerator-based stereotactic radiotherapy for meningiomas: hypofractionation and radiosurgery
Authors: Gawish Ahmed , Abdulayev Nurlan , El-Arayed Souhir , Röllich Burkard , Ochel Hans-Joachim , Brunner Thomas B. 
Published: October 2022

Abstract
Purpose
Meningioma is a common type of benign tumor that can be managed in several ways, ranging from close observation, surgical resection, and various types of radiation. We present here results from a 10 year experience treating meningiomas with a hypofractionated approach.

Materials and methods
To define the rate of tumor control and factors associated with the relief of symptoms and radiation-related complications after radiosurgery and hypofractionated radiosurgery for patients with imaging-defined intracranial meningiomas. We reviewed the charts of 48 patients treated with stereotactic radiosurgery (SRS) or hypofractionated stereotactic radiotherapy (SRT) from 2002 to 2018. A total of 37 (82%) patients had WHO Grade 1 disease, and 11 (22%) had Grade 2. Outcomes that were analyzed included local control rates and the rate and grade of any reported toxicity.

Results
Only 36 patients with 38 lesions, who underwent the follow-up regime, were enrolled in the retrospective analysis. The follow-up mean was 40 months (12–120 months). 25/34 patients had surgery before the radiotherapy. Sixteen underwent SRS with a median dose of 13, 5, and 20 received hypofractionated SBRT with a median dose of 26.9 (22-45 Gy) in median six fractions (5–13 fractions). Local control at 2 and 5 years for all patients was 90 and 70%, respectively. No patient suffered from toxicity > 2 CTC. 21/36 patients showed stable disease, while 8/36 patients showed partial Remission. 7/36 developed recurrent meningioma (five in-field), only one patient with grade 1 meningioma, in a median of 22 months (13–48 months).

Conclusion
SFRT was superior to SRS for local control in our analysis of Grade I meningiomas. This might be due to a tendency for higher EQD2 in the PTV with SFRT compared to SRS, which was reduced to avoid brain necrosis in large PTVs. Therefore, SFRT appears preferable for typical meningioma PTVs.
“It’s part of our life now”: a qualitative exploration of the social eating experiences of family members of patients living with head and neck cancer
Authors: Dornan Mark , Semple Cherith , Moorhead Anne 
Published: October 2022

Abstract
Purpose
Family members (FMs) of patients with head and neck cancer (HNC) report a change in their social eating experience. They miss out on the opportunities and benefits that eating with others provides. However, few studies investigate FM’s social eating experiences, with existing research primarily focusing on the patient experience. Therefore, the aim of this study was to explore the social eating experiences of FMs of patients who have had treatment for HNC.

Methods
A qualitative research design using semi-structured interviews was used to understand FM’s social eating experiences. Key themes were inductively developed from the data using reflexive thematic analysis.

Results
Twelve interviews were conducted with FMs, and three key themes were identified: (1) changes and challenges experienced by FMs due to HNC patients’ social eating difficulties, (2) living with social eating changes is a balancing act, and (3) FMs’ efforts to promote social eating for a patient with HNC. FMs expressed significant changes to their social eating habits within and outside the home, indicating the need for support to meet their own emotional, psychological and social needs.

Conclusion
FMs experience many demands and tensions, having to balance the psychological impact they experience, which are often minimised, whilst attempting to find the best ways to support, protect and encourage their loved ones to adjust and adapt to social eating changes. Therefore, interventions need to support FMs’ challenges and equip them to know how to best support patients living with HNC and themselves.
Aflibercept with FOLFIRI in Japanese patients with metastatic colorectal cancer: results of a post-marketing surveillance
Authors: Watanabe Jun , Terazawa Tetsuji , Yamane Shiho , Kazama Hirotaka , Uetake Hiroyuki , Yoshino Takayuki 
Published: October 2022

Abstract
Background
Safety and effectiveness of aflibercept with 5‐fluorouracil/levofolinate/irinotecan have not been reported in Japanese patients with metastatic colorectal cancer (mCRC) in a real-world clinical setting.

Methods
This post-marketing surveillance enrolled patients with un-resectable advanced or recurrent mCRC who were prescribed aflibercept from December 2017 to June 2019 in Japan. Data, collected up to 1 year from starting treatment, included patient background, safety, and effectiveness assessed by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or physician’s evaluation.

Results
Of 261 patients registered from 64 centers, 235 [53.2% male with a median age of 67 years (range 28–84)] received treatment and were included in the safety analysis. Aflibercept was received at 1st, 2nd, and ≥ 3rd line in 1.3%, 48.1%, and 50.2% of patients, respectively. Median number of treatment cycles was 6 (range 1–22) and relative dose intensity was 75.4% (range 14.3–101.8%). Adverse events (all grades) were reported in 88.5% of patients, including neutropenia (34.5%), proteinuria (24.7%), hypertension (17.0%), diarrhea (17.0%), and decreased appetite (15.3%). Three treatment-related deaths occurred by perforation of the digestive tract, pneumonia and gastrointestinal bleeding, and sudden death. The effectiveness analysis included 198 patients. Overall response rate was 6.1% (1st line, 0%; 2nd line, 10.1%; ≥ 3rd line, 2.1%) and disease control rate was 47.5% (1st line, 100%; 2nd line, 58.6%; ≥ 3rd line, 34.4%).

Conclusion
No new risks of aflibercept were identified in real clinical practice. Effectiveness in patients at the 2nd line was consistent with previous reports.
The role of cryptocurrencies in predicting oil prices pre and during COVID-19 pandemic using machine learning
Authors: Ibrahim Bassam A. , Elamer Ahmed A. , Abdou Hussein A. 
Published: October 2022

Abstract
This study aims to explore the role of cryptocurrencies and the US dollar in predicting oil prices pre and during COVID-19 pandemic. The study uses three machine learning models (i.e., Support vector machines, Multilayer Perceptron Neural Networks and Generalized regression neural networks (GRNN)) over the period from January 1, 2018, to July 5, 2021. Our results are threefold. First, our results indicate Bitcoin is the most influential in predicting oil prices during the bear and bull oil market before COVID-19 and during the downtrend during COVID-19. Second, COVID-19 variables became the most influential during the uptrend, especially the number of death cases. Third, our results also suggest that the most accurate model to predict the price of oil under the conditions of uncertainty that prevailed in the world during the bear and bull prices in the wake of COVID-19 is GRNN. Though the best prediction model under normal conditions before COVID-19 during an uptrend is SVM and during a downtrend is GRNN. Our results provide crucial evidence for investors, academics and policymakers, especially during global uncertainties.
Efficiently exploring for human robot interaction: partially observable Poisson processes
Authors: Jovan Ferdian , Tomy Milan , Hawes Nick , Wyatt Jeremy 
Published: October 2022

AbstractConsider a mobile robot exploring an office building with the aim of observing as much human activity as possible over several days. It must learn where and when people are to be found, count the observed activities, and revisit popular places at the right time. In this paper we present a series of Bayesian estimators for the levels of human activity that improve on simple counting. We then show how these estimators can be used to drive efficient exploration for human activities. The estimators arise from modelling the human activity counts as a partially observable Poisson process (POPP). This paper presents novel extensions to POPP for the following cases: (i) the robot’s sensors are correlated, (ii) the robot’s sensor model, itself built from data, is also unreliable, (iii) both are combined. It also combines the resulting Bayesian estimators with a simple, but effective solution to the exploration-exploitation trade-off faced by the robot in a real deployment. A series of 15 day robot deployments show how our approach boosts the number of human activities observed by 70% relative to a baseline and produces more accurate estimates of the level of human activity in each place and time.
Non-affine Fiber Reorientation in Finite Inelasticity
Authors: Ciambella Jacopo , Nardinocchi Paola 
Published: October 2022

AbstractThis paper introduces a model for the mechanical response of anisotropic soft materials undergoing large inelastic deformations. The material is considered made by a isotropic matrix with embedded fibers, each component having its own relaxation dynamics. The constitutive equations are provided in terms of the free energy density and the dissipation density, which are both required to be thermodynamically consistent and structural frame-indifferent, i.e., independent of a rotation overimposed on the intermediate natural state of both matrix and fibers. This is in contrast to many of the currently used anisotropic inelastic models, which do not deal with the lack of uniqueness of the intermediate state. This issue is thoroughly discussed and in terms of two possible choices satisfying structural-frame indifference and leading to different flow rules of the inelastic processes. It is shown that different models from the literature can be incorporated in the proposed formulation including anisotropic viscoelasticity and growth.
Pattern Labelling of Business Communication Data
Authors: Kaya Muhammed-Fatih 
Published: October 2022

AbstractSystematic pattern recognition as well as the corresponding description of determined patterns entail numerous challenges in the application context of high-dimensional communication data. These can cause increased effort, especially with regard to machine-based processing concerning the determination of regularities in underlying datasets. Due to the increased expansion of dimensions in multidimensional data spaces, determined patterns are no longer interpretable by humans. Taking these challenges into account, this paper investigates to what extent pre-defined communication patterns can be interpreted for the application area of high-dimensional business communication data. An analytical perspective is considered by taking into account a holistic research approach and by subsequently applying selected Machine Learning methods from Association Rule Discovery, Topic Modelling and Decision Trees with regard to the overall goal of semi-automated pattern labelling. The results show that meaningful descriptions can be derived for the interpretation of pre-defined patterns.
Do Journals Have Preferences? Insights from The Journal of Higher Education
Authors: Havey Nicholas , Chang Mitchell J. 
Published: October 2022

AbstractUsing five years of publishing data from the Journal of Higher Education, we describe the publication pipeline at the journal, explore trends with respect to topic, the geographic distribution of authors, and each paper's methodological approach. Following the presentation of these trends, we discuss implications for the field of higher education and those publishing within it.
Design and simulation of type-I graphene/Si quantum dot superlattice for intermediate-band solar cell applications
Authors: Sarkhoush Masumeh , Rasooli Saghai Hassan , Soofi Hadi 
Published: October 2022

AbstractRecent experiments suggest graphene-based materials as candidates for use in future electronic and optoelectronic devices. In this study, we propose a new multilayer quantum dot (QD) superlattice (SL) structure with graphene as the core and silicon (Si) as the shell of QD. The Slater–Koster tight-binding method based on Bloch theory is exploited to investigate the band structure and energy states of the graphene/Si QD. Results reveal that the graphene/Si QD is a type-I QD and the ground state is 0.6 eV above the valance band. The results also suggest that the graphene/Si QD can be potentially used to create a sub-bandgap in all Si-based intermediate-band solar cells (IBSC). The energy level hybridization in a SL of graphene/Si QDs is investigated and it is observed that the mini-band formation is under the influence of inter-dot spacing among QDs. To evaluate the impact of the graphene/Si QD SL on the performance of Si-based solar cells, we design an IBSC based on the graphene/Si QD (QDIBSC) and calculate its short-circuit current density (Jsc) and carrier generation rate (G) using the 2D finite difference time domain (FDTD) method. In comparison with the standard Si-based solar cell which records Jsc = 16.9067 mA/cm2 and G = 1.48943 × 1028 m−3⋅s−1, the graphene/Si QD IBSC with 2 layers of QDs presents Jsc = 36.4193 mA/cm2 and G = 7.94192 × 1028 m−3⋅s−1, offering considerable improvement. Finally, the effects of the number of QD layers (L) and the height of QD (H) on the performance of the graphene/Si QD IBSC are discussed.
Graphical abstract
Natural killer cell immunotherapy in glioblastoma
Authors: Hosseinalizadeh Hamed , Habibi Roudkenar Mehryar , Mohammadi Roushandeh Amaneh , Kuwahara Yoshikazu , Tomita Kazuo , Sato Tomoaki 
Published: October 2022

AbstractGlioblastoma (GBM) is one of the most difficult cancers to treat because GBM has the high therapeutic resistance. Recently, immunotherapies for GBM have been used instead of conventional treatments. Among them, Natural killer (NK) cell-based immunotherapy has the potential to treat GBM due to its properties such as the absence of restriction by antigen-antibody reaction and deep penetration into the tumor microenvironment. Especially, genetically engineered NK cells, such as chimeric antigen receptor (CAR)-NK cells, dual antigen-targeting CAR NK cells, and adapter chimeric antigen receptor NK cells are considered to be an important tool for GBM immunotherapy. Therefore, this review describes the recent efforts of NK cell-based immunotherapy in GBM patients. We also describe key receptors expressing on NK cells such as killer cell immunoglobulin-like receptor, CD16, and natural killer group 2, member D (NKG2DL) receptor and discuss the function and importance of these molecules.
Seasonal and diel activity patterns of small mammal guilds on the Pannonian Steppe: a step towards a better understanding of the ecology of the endangered Hungarian birch mouse (Sicista trizona) (Sminthidae, Rodentia)
Authors: Cserkész Tamás , Kiss Csaba , Sramkó Gábor 
Published: October 2022

AbstractTemporal activity differences facilitate species’ coexistence by reducing interspecific competition. Such patterns can be studied via diel activity analysis, but obtaining data in cryptic mammals is difficult. We investigated the annual and diel activity pattern of such a small mammal, the endangered Hungarian birch mouse (Sicista trizona trizona), in its only known habitat. We employ trail cameras for the first time to reveal the diel and annual activity of a sminthid species. Data acquisition included the spring and summer seasons between 2019 and 2022 and was extended to detect the activity overlaps with other common coexisting rodents and shrews. The diel activity results rely on 581 detections of S. trizona over 5670 trap-nights of camera trap deployment characterising also activity pattern of the small mammal community in this Central European grassland ecosystem. S. trizona was not recorded during the day but was active at dawn and night, and in comparison with other coexisting species, its activity level was high. The presumed cold sensitivity was not confirmed as we detected activity at −6 °C. Diel activity peaked in early May in the mating season. Although the diel activity pattern of co-occurring small mammal species was also nocturnal, activity overlaps were relatively high suggesting that temporal niche partitioning is limited within the habitat. Our work provides the first insight into temporal overlaps within a small mammal community in a natural European grassland, moreover, also the first documented research on the activity pattern of a sminthid in its natural habitat.
The final frontier: what is distinctive about the bioethics of space missions? The cases of human enhancement and human reproduction
Authors: Szocik Konrad , Reiss Michael J. 
Published: October 2022

AbstractWe examine the bioethical issues that arise from long-duration space missions, asking what there is that is distinctive about such issues. We pay particular attention to the possibility that such space missions, certainly if they lead to self-sustaining space settlements, may require human enhancement, and examine the significance of reproduction in space for bioethics. We conclude that while space bioethics raises important issues to do with human survival and reproduction in very hazardous environments, it raises no issues that are distinct from those in terrestrial bioethics. Rather, space bioethics raises extreme versions of bioethical issues that are already found in the military, when working in extreme environments (such as Antarctica), or when living in circumstances (such as in prison) where one’s autonomy is severely curtailed.
Considering Global Development? Insights from Applications for FDA Breakthrough Therapy and EMA PRIME Designations
Authors: Hanaizi Zahra , Kweder Sandra , Thor Shannon , Ribeiro Sonia , Marcal Anabela 
Published: October 2022

AbstractThe United States Food and Drug Administration and the European Medicines Agency (EMA) each have programs to expedite development of products identified as having potential to address unmet medical needs: the Breakthrough therapy (BT) and Regenerative Medicines Advanced Therapies designation programs in the US and the Priority Medicines (PRIME) scheme at EMA. We reviewed commonalities and differences in requests submitted and products designated through these programs, with the intent to explore ways to better support global development. During the period from PRIME’s launch in April 2016 to 31 December 2020, 151 requests were made to both BT and PRIME programs and the agencies reached concordant outcomes to grant or deny requests for almost two thirds of the cases (93/151, 62%), suggesting similar perspectives across international regulators on the potential of the products under study. Forty-two (42/151, 28%) products were granted both BT and PRIME, thus found by both Agencies to have the potential to address an unmet need for a serious condition, and thereby products for which efficient development would be highly desirable. Working toward better engagement on global development strategies is in the best interests of patients and public health. With this in mind, Agencies and sponsors should take advantage of existing collaborative opportunities, such as parallel scientific advice, and work to identify fresh approaches to support global development of products for unmet medical needs.
Perceived privacy in home office and musculoskeletal complaints: a test of family–work conflict, work–family conflict, and relaxation as mediators
Authors: Wütschert Milena Sina , Pereira Diana , Eggli Andrea , Schulze Hartmut , Elfering Achim 
Published: October 2022

AbstractMany employees have had to telework all year during the COVID-19 pandemic. Even though working from home has many advantages, there are also some disadvantages worth to consider. Lack of privacy is a relevant factor when it comes to the development of severe musculoskelatal issues. This study investigated the link between perceived privacy in home office and musculoskeletal complaints (MSCs). Family–work conflict (FWC), work–family conflict (WFC), and relaxation were tested as potential mediators for the relationship between perceived privacy and MSCs. The present study’s questionnaire was filled out by 287 teleworking employees. Hypotheses were tested via multiple mediation analyses examining levels of perceived privacy in home office, and its relationship on MSCs. Furthermore, the underlying effect of FWC, WFC, and MSCs were tested with a structural equation model. As assumed, lack of privacy while working at home was linked to individuals more frequently experiencing MSCs. However, the structural equation model showed no significant mediation effect. Work design efforts must address privacy while employees perform telework at home to prevent MSCs.
Urban rail transit FAO system: technological development and trends
Authors: Tang Tao , Liu Wentao , Ding Shukui , Gao Chunhai , Su Shuai 
Published: October 2022

AbstractThis paper introduces the worldwide history of fully automatic operation (FAO) system in urban rail transit, followed by the development status in China. Then, the architecture and characteristics of the FAO system are described, and the analysis method of system design requirements is proposed based on the human factors engineering. The key technologies are introduced from the aspects of signaling system, vehicle system, communication system, traffic integrated automation system and reliability, availability, maintainability, and safety (RAMS) assurance. Furthermore, based on the independent practical experience of the FAO system, this paper summarizes the management methods for the construction and operation of FAO lines and prospects its future development trends toward a more intelligent urban rail transit system.