bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peritoneal M2 macrophage-derived extracellular vesicles as natural multi-target nanotherapeutics to attenuate cytokine storm after severe infections
Authors: Wang Yizhuo , Liu Shuyun , Li Lan , Li Ling , Zhou Xueli , Wan Meihua , Lou Peng , Zhao Meng , Lv Ke , Yuan Yujia , Chen Younan , Lu Yanrong , Cheng Jingqiu , Liu Jingping 
Published: March 2022

AbstractCytokine storm is a primary cause for multiple organ damage and death after severe infections, such as SARS-CoV-2. However, current single cytokine-targeted strategies display limited therapeutic efficacy. Here, we report that peritoneal M2 macrophages-derived extracellular vesicles (M2-EVs) are multi-target nanotherapeutics to resolve cytokine storm. In detail, primary peritoneal M2 macrophages exhibited superior anti-inflammatory potential than immobilized cell lines. Systemically administrated M2-EVs entered major organs and were taken up by phagocytes (e.g., macrophages). M2-EVs treatment effectively reduced excessive cytokine (e.g., TNF-α and IL-6) releasein vitroandin vivo, thereby attenuated oxidative stress and multiple organ (lung, liver, spleen and kidney) damage in endotoxin-induced cytokine storm. Moreover, M2-EVs simultaneously inhibited multiple key proinflammatory pathways (e.g., NF-κB, JAK-STAT and p38 MAPK) by regulating complex miRNA-gene and gene-gene networks, and this effect was collectively mediated by many functional cargos (miRNAs and proteins) in EVs. In addition to the direct anti-inflammatory role, human peritoneal M2-EVs expressed angiotensin-converting enzyme 2 (ACE2), a receptor of SARS-CoV-2 spike protein, and thus could serve as nanodecoys to prevent SARS-CoV-2 pseudovirus infectionin vitro. As cell-derived nanomaterials, the therapeutic index of M2-EVs can be further improved by genetic/chemical modification or loading with specific drugs. This study highlights that peritoneal M2-EVs are promising multifunctional nanotherapeutics to attenuate infectious diseases-related cytokine storm.
Lnc956-TRIM28-HSP90B1 complex on replication forks promotes CMG helicase retention to ensure stem cell genomic stability and embryogenesis
Authors: Zhang Weidao , Tang Min , Wang Lin , Zhou Hu , Gao Jing , Chen Zhongliang , Zhao Bo , Zheng Ping 
Published: March 2022

AbstractReplication stress is a major source of endogenous DNA damage. Despite that numerous proteins have been identified on replication forks to modulate fork or replication machinery activities, it remains unexplored whether non-coding RNAs can localize on stalled forks and play critical regulatory roles. Here we identify an uncharacterized lncRNA NONMMUT028956 (Lnc956 for short) predominantly expressed in mouse embryonic stem cells. Lnc956 is recruited to stalled replication forks to prevent fork collapse and preserve genomic stability, and is essential for mouse embryogenesis. Mechanistically, it drives assembly of the Lnc956-TRIM28-HSP90B1 ribonucleoprotein (RNP) complex on stalled forks in an inter-dependent manner downstream of ATR signaling. This RNP complex physically associates with MCM2-7 hexamer via TRIM28 and directly regulates the CMG helicase retention on chromatin. The regulation of RNP on CMG retention is mediated by HSP90B1’s chaperoning function. These findings reveal a novel pathway which actively regulates replisome retention to prevent fork collapse.
Independent effect and joint effect of polygenic liabilities for schizophrenia and bipolar disorder on cognitive aging and education attainment
Authors: Wu Chi-Shin , Hsu Chia-Lin , Lin Mei-Chen , Su Mei-Hsin , Lin Yen-Feng , Chen Chia-Yen , Hsiao Po-Chang , Pan Yi-Jiun , Chen Pei-Chun , Huang Yen-Tsung , Wang Shi-Heng 
Published: March 2022

AbstractTo elucidate the specific and shared genetic background of schizophrenia (SCZ) and bipolar disorder (BPD) to better understand their nosology, this study explored the independent and joint effects of polygenic liabilities for SCZ and BPD on cognitive aging and educational attainment among a collection of 80318 unrelated community participants from the Taiwan Biobank. Using the Psychiatric Genomics Consortium meta-analysis as a discovery sample, we calculated the polygenic risk score (PRS) for SCZ (PRSSCZ) and BPD (PRSBPD), shared PRS between SCZ and BPD (PRSSCZ+BPD), and SCZ-specific, differentiated from BPD, PRS (PRSSCZvsBPD). Based on the sign concordance of the susceptibility variants with SCZ and BPD, PRSSCZ was split into PRSSCZ_concordant and PRSSCZ_discordant and PRSBPD was split into PRSBPD_concordant and PRSBPD_discordant. Linear regression models were used to estimate the association with cognitive aging as measured by the Mini-Mental State Examination (MMSE) in individuals aged ≥ 60 years. Ordinal logistic regression models were used to estimate the association with educational attainment. PRSSCZ was negatively associated with MMSE (beta=-0.063, p<0.001), while PRSBPD was positively associated with MMSE (beta=0.04, p=0.01). A larger difference between PRSSCZ and PRSBPD was associated with lower MMSE scores (beta=-0.052, p<0.001). Both PRSSCZ_concordant and PRSSCZ_discordant were negatively associated with MMSE scores, without a synergistic effect. There was a complex interaction between PRSBPD_concordant and PRSBPD_discordant on the MMSE scores. PRSSCZ+BPD (beta=-0.09, p=0.01) and PRSSCZvsBPD (beta=-0.13, p<0.001) predicted a decrease in MMSE scores during the follow-up. PRSSCZ, PRSBPD, and PRSSCZ+BPD were positively associated with educational attainment, whereas PRSSCZvs BPD was negatively associated with educational attainment. This study provides evidence for the contrasting effect of polygenic liabilities for SCZ and BPD on cognitive aging and partially supports the hypothesis that the heterogeneity of SCZ and the positive association of polygenic liability for SCZ with education might be attributed to the shared part with BPD.
Obesity, hypertension and tobacco use associated with left ventricular remodelling and hypertrophy in South African Women: Birth to Twenty Plus Cohort
Authors: Kolkenbeck-Ruh Andrea , Soepnel Larske M. , Crouch Simone H. , Naidoo Sanushka , Smith Wayne , Norris Shane A. , Davies Justine , Ware Lisa J. 
Published: March 2022

AbstractBackgroundLeft ventricular hypertrophy (LVH) is a known marker of increased risk in developing future life-threating CVD, though it is unclear how health risk factors, such as obesity, blood pressure and tobacco use, associate with left ventricular (LV) remodelling and LVH across generations of urban African populations.MethodsBlack female adults (n=123; age: 29-68 years) and their children (n=64; age: 4-10; 55% female) were recruited from the Birth to Twenty Plus Cohort in Soweto, South Africa. Tobacco and alcohol use, physical activity, presence of diabetes mellitus, heart disease and medication were self-reported. Height, weight, and blood pressure were measured in triplicate. Echocardiography was used to assess LV mass at end-diastole, perpendicular to the long axis of the LV and indexed to body surface area to determine LVH.ResultsHypertension and obesity prevalence were 35.8% and 59.3% for adults and 45.3% and 6.3% for children. Self-reported tobacco use in adults was 22.8%. LVH prevalence was 35.8% (n=44) in adults (75% eccentric; 25% concentric), and 6.3% (n=4) in children (all eccentric). Prevalence of concentric remodelling was 15.4% (n=19) in adults and observed in one child. In adults, obesity (OR: 2.54 (1.07-6.02; p=0.02) and hypertension (3.39 (1.08-10.62; p=0.04) significantly increased the odds of LVH, specifically eccentric LVH, while concentric LVH was associated with self-reported tobacco use (OR: 4.58 (1.18-17.73; p=0.03; n=11). Although no logistic regression was run within children, of the four children LVH, three had elevated blood pressure and the child with normal blood pressure was overweight.ConclusionsThe association between obesity, hypertension, tobacco use and LVH in adults, and the 6% prevalence of LVH in children, calls for stronger public health efforts to control risk factors and monitor children at who are risk.
Plasma monopole antenna array
Authors: Papadimopoulos Athanasios , Di Iorio Alessio 
Published: March 2022

Purpose
This study aims to investigate different configurations of plasma antenna arrays and multiple combinations based on whether the plasma dischargers are set ON or OFF, to assess the coupling, interference and overall performance of these plasma antenna arrays.

Design/methodology/approach
In this paper, the authors investigate the operation and performance of the combined use of sets of antennas and plasma antenna elements in plasma monopole antenna arrays.

Findings
The authors find that there can be significant modifications of the plasma antenna arrays’ gain and pattern in multiple ways, merely by switching different combinations of plasma columns ON and OFF.

Originality/value
High-density plasma antenna arrays have been examined in this paper and it has been shown that they are capable of reaching high antenna gain. Moreover, the overall antenna array’s gain and pattern can be considerably transformed in multiple ways by turning ON and OFF different combinations of plasma antenna elements. Finally, the electromagnetic coupling and interference coming from these plasma antennas can be greatly reduced.
A viable MBA for BoP students: PiMS in rural Kasaragod, Kerala
Authors: John Kishore Thomas , Kamala Raghavan Ajith Kumar 
Published: March 2022

Learning outcomes
Participants will learn to analyze the basis of consumer segmentation in management education. It will specifically highlight the importance of positioning in influencing the marketing strategy of a firm and discuss the importance of a differentiated-low cost strategy to gain competitive advantage. The case will familiarize students with the business environment of rural India, and the applicability of the 4A’s and the 5D’s framework. Finally, the case will help participants understand the difference between a rural market and a Bottom-of-Pyramid (BoP) market.

Case overview/synopsis
A rural MBA institute for BoP students is grappling with the problem of low admissions, leading to an existential crisis. Two divergent options are presented to the protagonist. The first is to close down the B-school and use the infrastructure and facilities for a well-funded government skill development program which is vocational and intended for creating blue-collar workers. The second is to find ways to bolster the B-school to ensure that it gets adequate student enrollment, thereby leading to profitability.

Complexity academic level
This case is suitable for an undergraduate or MBA course in marketing management, rural marketing in India, South-Asian marketing or strategic marketing.

Supplementary materials
Teaching notes are available for educators only. Please contact your library to gain login details or e-mail support@emeraldinsight.com to request teaching notes. There is an accompanying spreadsheet with the case for studying the market. It contains relevant market data that would support analysis of the case. Comments are added for easy understanding. Instructors can access the separate spreadsheet that works out the break-even calculations for the fee structure of the institute. Instructions on calculations as well as comments are added for easy understanding.

Subject code
CSS 8: Marketing.
A deeper understanding of student preferences for in-class video use: a segmentation analyses of needs, group differences and preference clusters
Authors: Salehudin Imam , Alpert Frank 
Published: March 2022

PurposeThis study analyzed segment differences of student preference for video use in lecture classes and university use of video lecture classes. The authors then conducted novel gap analyses to identify gaps between student segments' preferences for videos versus their level of exposure to in-class videos. Multivariate analysis of variance (MANOVA) was used to identify significant factors that explain the gaps.Design/methodology/approachSegment differences of student preference for video use in lecture classes and university use of video lecture classes were analyzed. Novel gap analyses were then conducted to identify gaps between student segments' preferences for videos versus their level of exposure to in-class videos. MANOVA was used to identify significant factors that explain the gaps.FindingsGap analysis of video preference relative to video exposure showed a bimodal distribution, with an approximately even split between students with an overall deficit (44.5%) and surplus (47%) of in-class videos. Deficit means students preferred to see more videos than what the lecturer showed them. Surplus means the lecturer showed students more videos than they preferred to see. Further analyses break down the deficits and surpluses based on the type of videos shown.Practical implicationsResults are useful as an effective diagnostic tool for education managers because they are not at the individual student level but rather by course level. One implication for educational managers is that a one-size-fits-all approach for all courses will benefit some students and annoy others.Originality/valueThis paper extends Alpert and Hodkinson’s (2019) findings by identifying preference clusters and performing segmentation analyses based on finer-grained disaggregated data analysis.
Enhancing the quality of project management through action research
Authors: Coghlan David , Shani Abraham B. (Rami) , Coughlan Paul 
Published: March 2022

PurposeThe article brings the quality characteristics of action research to project management and explores how these quality characteristics of well-designed and executed action research can inform and enhance the practice of project management.Design/methodology/approachA reflective paper.FindingsThe article identifies five imperatives in bringing together action research and project management. The authors argue that project management may be conducted in a manner that is rigorous, reflective and relevant.Research limitations/implicationsThe integration of project management and action research is not empirically described. Therefore, researchers are encouraged to test and further develop the model in relation to the design and management of projects.Practical implicationsPractical questions are posed for implementation.Social implicationsThe integration of action research and project management is a collaborative venture and the engagement imperative emphasizes that collaboration.Originality/valueBy bringing together action research and project management the article integrates five imperatives: design, engagement, improvement, action and research and quality characteristics of action research to enhance project management as rigorous, reflective and relevant.
Giving over selling: advertising for the social enterprise
Authors: Coleman Joshua T. 
Published: March 2022

PurposeA social enterprise is a hybrid business organization which pursues both profit maximization and social change. This study aims to explore effective ways to communicate authentic motives through social enterprise advertisements.Design/methodology/approachFour sets of advertisements were created to explore the effects of different message cues on perceived authenticity. These ads were presented through internet surveys in varying combinations.FindingsPer cue congruency theory, when both giving and selling cues are presented together, they contradict one another, thereby neutralizing any positive feelings which would otherwise be gained through the use of a giving cue. Thus, the highest perceptions of authentic motives underlying an advertisement are gained when only giving cues are used.Practical implicationsSocial entrepreneurs should recognize the limitations of presenting both giving and selling cues in tandem with one another. Doing so may help increase profitability and sales, but it will decrease the authenticity of a perceived message. To communicate authenticity through advertising, the social entrepreneur should highlight the social enterprise’s mission and giving characteristics rather than the products or services being sold.Originality/valueTo the best of the author’s knowledge, this research is among the first to explore authenticity in marketing messages for the social enterprise. Further, while extant research identifies methods of overcoming contradictory message appeals, the novel findings of this research demonstrate the effectiveness of avoiding the potential for negative reactions altogether.
Launching the Internet of Things: how to ensure a successful debut
Authors: Gimpel Gregory , Vander Weerdt Candice M. 
Published: March 2022

Purpose
Companies that leverage the Internet-of-things (IoT) will gain significant competitive advantages over the competition; however, few businesses have active IoT initiatives. This paper aims to provide principles to guide executives as they launch or scale-up IoT initiatives.

Design/methodology/approach
This paper draws upon data from original expert interviews and an extensive study of existing scholarly literature, management publications and white papers from leading strategy and technology firms.

Findings
Close cooperation among a company’s operations, business strategy and information technology units creates a trifecta of skills, vision and budgeting that can successfully bring major IoT initiatives to fruition. Unfortunately, many companies face a misalignment among these departments. The way to overcome this misalignment is to create a cross-functional team dedicated to IoT initiatives. Leaders should build these teams on the principles of autonomy, rational compensation, equality and diversity.

Practical implications
This paper provides strategic advice for business leaders as well as four guiding principles with which to execute their IoT strategies.

Originality/value
Much of the writing about IoT advocates initiatives by teaching about the many business benefits of IoT or provides a use case for a specific type of IoT technology. This paper focuses on removing a major obstacle faced by many business leaders who want to embrace the IoT but find themselves unable to do so.
The development of Islamic accounting education in the UAE and its challenges: an institutional perspective
Authors: Grassa Rihab , Khlif Hichem , Khelil Imen 
Published: March 2022

Purpose
This paper aims to examine the development of Islamic accounting education and discuss the main challenges facing this specific type of accounting education in the United Arab Emirates (UAE).

Design/methodology/approach
The paper uses institutional theory to analyze the development of Islamic accounting education in the UAE. The collection of information in this study is based on secondary data available from published sources and websites.

Findings
This study identifies three types of institutional pressures. First, coercive pressures that were directed by the government, the UAE's Central Bank and other professional bodies [e.g. Accounting and Auditing Organization of Islamic Financial Institutions (AAOIFI)] involved in the Islamic banking industry have contributed to the development of Islamic accounting education in the UAE. Second, mimetic pressures exerted by other countries that have already established Islamic accounting training and programs (e.g. Indonesia, Iran, Kingdom of Saudi Arabia and Pakistan) have incentivized the UAE business schools to implement Islamic accounting training and programs to meet Emirati Islamic banking industry expectations. Third, normative pressures are exerted by Big 4 auditors who have an active position as faculty members, influencing status in AAOIFI and a dominant position in the Islamic banking industry’s audit market. The paper also discusses the main challenges facing Islamic accounting education in this country.

Originality/value
This paper contributes to accounting literature in general and accounting education literature in particular in the following two ways. First, this study applies an institutional analysis to Islamic accounting education in the UAE to gain more understanding about the current status of the development of Islamic accounting education in the UAE. Second, by identifying the factors that may constrain the development of Islamic accounting education in the UAE, this study provides recommendations to financial and higher education authorities to undertake proactive actions to position the UAE as a leading center in Islamic accounting education and training.
Need for distinction moderates customer responses to preferential treatment
Authors: Pontes Vivian , Greer Dominique A. , Pontes Nicolas , Beatson Amanda 
Published: March 2022

PurposeThis paper aims to examine how individuals’ need for distinction moderates the effect of perceived harm to others as a result of preferential treatment on customers’ attitudes towards the service provider.Design/methodology/approachTwo experiments test the hypothesis that when a customer receives preferential treatment, the effect of perceived harm to others on the customer’s attitudes towards the service provider is moderated by their need for distinction and mediated by negative moral emotions, such that mediation occurs for customers with a lower (but not higher) need for distinction.FindingsWhen customers have a lower need for distinction, they scan the environment to seek information about others when judging their own experience. In contrast, customers with a higher need for distinction tend to disregard others’ opinions and feelings, focusing solely on the benefits they receive from the service provider and avoiding moral emotions. Our results show that customers with a higher need for distinction tend to evaluate the service provider more favourably than those with a lower need for distinction in scenarios where the benefit given to an advantage customer imposes a disadvantage on other customers.Originality/valueTo the best of author’s knowledge, this research is the first to examine the interaction between perceived harm to others and one’s need for distinction as drivers of customers’ response to preferential treatment. The authors are the first to show that negative moral emotions may arise for customers with a lower need for distinction but not for those with a higher need for distinction.
A comparative study of corrosion resistance of epoxy-based coating incorporated chitosan, silica and hybrid compound of chitosan/silica on mild steel
Authors: Wonnie Ma Iling Aema , Kumar Sachin Sharma Ashok , Kasi Ramesh , Shafaamri Ammar , Subramaniam Ramesh 
Published: March 2022

Purpose
This study aims to propose that the corrosion resistance of the neat epoxy coating can be further enhanced by incorporating reinforcing agents.

Design/methodology/approach
Chitosan, silica and their hybrid compound were used to study the subject of corrosion resistance of epoxy coating systems. This work used 3.5 Wt.% NaCl solution as the electrolyte, and electrochemical impedance spectroscopy (EIS) was used to investigate the electrochemical behaviour of the studied coating systems. Standard and accelerated states were used without and with scratch on the coating layer.

Findings
It was found that the impedance value of composite coating incorporated with the hybrid compound was significantly higher at 1010 Ω after 14 days of exposure in both testing states. The breakpoint frequency (fb) determination also proves with large capacitive region at low-to-high frequency of impedance plots corresponding to the high corrosion resistance.

Originality/value
The hybrid compound consisting of chitosan as organic biopolymer and silica as inorganic material, respectively, served as a promising reinforcing agent for composite coating as a promising corrosion inhibitor. Different states of EIS measurement were used which are standard (without scratch) and accelerated (with scratch) states associated with the fb values.