bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary Inflammatory Index and osteoporosis: the National Health and Nutrition Examination Survey, 2017–2018
Authors: Jin Lina , Yang Shuman , Zhao Saisai , Tong Li , Gao Wenhui , Sun Mengzi , he yue , wang yanfang , zhang yuan , xu yan , fang jiaxin 
Published: June 2022

Abstract
Purpose: The dietary inflammatory index (DII) is a scoring system to quantify the inflammatory effects of nutrients and foods, while inflammation could affect osteoporosis. The purpose of this study was to further explore the relationships between DII and BMD and osteoporosis in both women and men. Methods: This study was involved 1070 women and 1136 men (age ≥ 50) in the US National Health and Nutrition Survey (NHANES) from 2017 to 2018. Multivariable linear regression models were used to estimate the associations between DII and BMD. And the correlations of DII and the risk of osteoporosis were estimated with multivariable logistic regression models. Results: In women, DII was negatively associated with lumbar spine, total hip and femoral neck BMD after adjusting for covariates in model 3, respectively (P<0.05). In men, DII was negatively associated with lumbar spine BMD (P<0.05). Multiple logistic regression analyses revealed that in women DII was positively associated with the risk of osteoporosis in models (P<0.05). The significantly increased odds ratios (ORs) (95% CI) of the model 3 between the risk of osteoporosis and DII across quartiles 2, 3 and 4 compared with quartile 1 were 3.071 (95% CI 1.168,8.070), 5.631 (95% CI 2.808,11.293), and 6.169(95% CI 2.964,12.838), respectively. But no significant association was observed in men. Conclusions: This study revealed that higher DII score was associated with higher osteoporosis risk in women, while no association was found in men. more pro-inflammatory diets might be associated with lower BMD in both women and men.
Fabrication of nanocomposite membrane based on post-synthetic modification of two-dimensional metal-organic framework nanosheet
Authors: Zhang Liying , Li Mengchu , Wang Xuanhe , Zhang Xuemin , Wang Tieqiang , Fan Fuqiang , Fu Yu 
Published: June 2022

Abstract
Two-dimensional metal-organic framework (2D MOF) nanosheet is becoming as an attractive type of 2D materials. And Post-synthetic modification (PSM) provides a powerful method to modify the structure of MOF without altering its crystal topology, which can generate functional MOFs not accessible from direct synthesis and improve the compatibility between MOFs and other components in MOF-based composite materials, especially in MOF/polymer composite. In this work, a facile method based on PSM of 2D MOF with polymers is conducted to prepare functional nanocomposite membrane. First, the amino-functioned 2D MOF nanosheet, CuBDC-NH2 (BDC-NH2 is 2-amino-1,4-benzenedicarboxylate), is prepared by a feasible and convenient method as the PSM precursors. Then CuBDC-NH2 nanosheet reacts with isocyanate-terminated polyurethane (PU) oligomer through PSM to obtain CuBDC-NH2/PU nanocomposite membrane. As-prepared nanocomposite membrane shows over 93.0% removal rate for dye removal, such as methylene blue, Rhodamine B and Eosin Y, which paves new ways for the application of 2D MOF by facilely fabrication of functional 2D MOF-based nanocomposite membrane through PSM.
The expression, prognostic value and potential mechanism of PLCB2 in clear cell renal cell carcinoma
Authors: Ji Xing , Zhu Zhenpeng , Cai Tianyu , Xu Chunru , Lin Jian 
Published: June 2022

Abstract
Objective: Clear cell renal cell carcinoma (ccRCC) is a malignant tumor with dismay outcome. Probing the potential mechanisms of tumorigenesis and progression, identifying valid diagnostic and prognostic biomarkers of ccRCC remain urgent. This study aimed to screen out novel biomarkers and potential therapeutic targets of ccRCC. Methods: In this study, based on our own database and public databases such as TCGA, GEO, GTEx, CPTAC and CCLE, we performed a systematic study of the expression and prognostic value of PLCB2. The differentially expressed genes (DEGs) between ccRCC and normal tissues were explored for further functional enrichment analysis includes Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA). Afterward, immune cell infiltrates analysis was established to evaluate the correlation between PLCB2 expression and immune cell infiltration level. Results: PLCB2 weas significantly higher in tumors than in normal tissues not only at transcriptional but translational levels in various cancers, including ccRCC. Logistic regression analysis revealed that higher expression level of PLCB2 was significantly correlated with worse clinicopathological characteristics. Furthermore, Kaplan-Meier survival analysis demonstrated that ccRCC cases with high PLCB2 expression had poor OS. Cox regression demonstrated that the transcriptional level of PLCB2 was confirmed to be an independent prognostic factor for OS in ccRCC patients. In functional enrichment analysis, except for classical oncogenic signaling pathways, most DEGs were enriched in immune response related pathways, indicating that PLCB2 may influence the occurrence and progression of ccRCC by regulating immune infiltration. Afterward, immune cell infiltrates analysis comfirmed that the expression level of PLCB2 has a significantly relationship with the infiltration levels of CD8+ T cells, which indicated that PLCB2 might be a candidate target for cancer immunotherapy. Conclusions: Our study provides valuable insights into the role of PLCB2 as a new diagnostic and prognostic biomarker and novel therapeutic target for ccRCC.
Efficacy and safety of nitazoxanide in treating SARS-CoV-2 infection: A systematic review and meta-analysis of blinded, placebo- controlled, randomized clinical trials
Authors: Martins-Filho Paulo Ricardo , Nascimento-Júnior Edmundo Marques do , Barreto-Alves José Antônio , Fakhouri Ricardo , Ferreira Lis Campos 
Published: June 2022

Abstract
Purpose: Nitazoxanide is a broad-spectrum antiparasitic that has been tested for COVID-19 due to its anti-inflammatory effects and in vitro antiviral activity. This study synthesized the best evidence on the efficacy and safety of nitazoxanide in COVID-19. Methods: Searches for studies were performed in peer-reviewed and grey-literature. The following elements were used to define eligibility criteria: (1) Population, individuals with COVID-19; (2) Intervention, nitazoxanide; (3) Comparison, placebo; (4) Outcomes: viral load, positive RT-PCR status, composite measure of disease progression (ICU admission or invasive mechanical ventilation), death, serum biomarkers of inflammation, and any adverse events; (5) Study type: blinded, placebo-controlled, randomized clinical trials (RCTs). Results: Five blinded, placebo-controlled RCTs were included and enrolled individuals with mild or moderate SARS-CoV-2 infection. We found no difference between nitazoxanide and placebo in reducing viral load and frequency of positive RTP-PCR results. In addition, there was no decreased risk for disease progression and death among patients receiving nitazoxanide. Patients with COVID-19 treated with nitazoxanide had decreased levels of white blood cells, lactate dehydrogenase, and D-dimer compared to placebo, but the magnitude of effect was considered small to moderate. Conclusion: Available evidence based on the results of blinded, placebo-controlled, RCTs showed no clinical benefits of nitazoxanide in COVID-19.
Heart rhythm complexity impairment in end stage renal disease patients receiving haemodialysis
Authors: Sun Weiwei , Xiong Hui , Peng Chung-Kang , Ahn Andrew C. , Liu Qingqing , Yan Runze , Wu Qiaoru , Wei Shuwu , Yuan Kai , Zhou Jingwei 
Published: June 2022

Abstract
Cardiovascular disease (CVD) is one of the most common complications of end stage renal disease (ESRD) patients receiving haemodialysis (HD). A better understanding of the relationship between CVD and HD is important to improve life expectancy and reduce the mortality risk of ESRD patients receiving HD. Heart rate variability (HRV), also known as variations in heart rate, is a useful method to measure the autonomic nervous system dys-regulation with 24-h electrocardiogram (ECG). The variables of heart rhythm complexity could be acquired with multi-scale entropy analysis (MSE). We enrolled 31 ESRD patients receiving HD in this study. MSE was used as non-linear heart rate variability (HRV) in our study. MSE area was negative correlated with age. MSE area 10-20 was positive correlated with Kt/V, albumin (ALB) and hemoglobin (Hb). Furthermore, we found that the MSE area before HD was higher than the MSE area after HD. We also found that increased age was a deleterious factor of HRV in ESRD patients receiving HD. Kt/V, ALB, and Hb were beneficial factors of HRV in ESRD patients receiving HD. HD seemed to be a harmful factor of HRV in ESRD patients.
Status, threats, and overlap of globally important pangolins and threatened small carnivores in a disturbed wetland mosaic of southern Vietnam
Authors: Gray Russell , Nguyen Tan , Cao Long Nhat , Trinh Mai Thi , Pham Thong , Nguyen Huyen Thi Thanh , Willcox Daniel , Le Dzung , Nguyen Thai Van 
Published: June 2022

Abstract
The U Minh wetlands of southern Vietnam in Ca Mau and Kieng Giang provinces are a degraded, peat-swamp wetland mosaic known to retain several globally threatened species. We deployed intensive, targeted camera-traps across U Minh Thuong National Park and U Minh Ha National Park from December 2019 to May 2020, and from November 2020 to June 2021, respectively. Our aim was to detect threatened otters, wild cats, and pangolins in each protected area, to identify what potential threats they may face, and to inform conservation priorities for park managers. Our results showed that both protected areas harbour significant regionally important populations of globally threatened Sunda pangolins (Manis javanica), and Hairy-nosed otters (Lutra sumatrana). However, Fishing cats (Prionailurus viverrinus) and Large-spotted civet (Viverra megaspila) previously recorded from U Minh Thuong National Park, were not observed. Other than wide-ranging species insensitive to human disturbance (i.e., Common palm civets and Leopard cats), all small carnivores were most active in Melaleuca and swamp/Melaleuca habitats in U Minh Thuong, and both the wetland plantations and disturbed forests of U Minh Ha according to their photographic rates. Human and domestic dogs’ activity periods in both protected areas overlapped strongly with Hairy-nosed otters, which could influence their dispersal abilities and access to resources. Furthermore, dogs in this part of southern Vietnam are often used for hunting, so there is a strong possibility the overlap could lead to deadly interactions as well. Long-term and short-term threats are discussed with relevance to U Minh ecosystem health and future recommendations.
Single port thoracoscopic pulmonary metastasectomy can improve survival in esophageal cancer patients with pulmonary metastasis
Authors: Lo Chien-Ming , Chuang Kai-Hao , Lai Hsing-Hua , Chen Yu , Chen Li-Chun , Lu Hung-I , Chen Yen-Hao , Li Shau-Hsuan 
Published: June 2022

Abstract
Objectives:Esophageal cancer with pulmonary metastasis has a poor prognosis. Pulmonary metastasectomy provides benefits in selected patients; however, currently, there is no literature regarding single port surgery for these patients. We reviewed our institution’s data and analyzed patient outcomes after single port pulmonary metastasectomy.Methods:We retrospectively reviewed our patients with esophageal cancer and pulmonary metastasis. We categorized them into two groups - the pulmonary resection group and the systemic treatment group. We compared the overall survival and progression-free survival between groups and also analyzed the surgical modality, which includes single or multiple port surgery.Results:The analysis included 44 patients, 14 of whom received pulmonary metastasectomy. Ten patients underwent single port surgery. Single port pulmonary metastasectomy showed significant benefits on overall survival (p=0.0009), while all pulmonary resection demonstrated benefits on overall survival (p<0.0001) and progression-free survival (p=0.038).Conclusions:Single port pulmonary metastasectomy in patients with esophageal cancer demonstrated survival benefits even when this procedure was performed for tissue diagnosis.
Nonintrusive Measurement on Temporal and Spatial Features of Microservice Inferences
Authors: Li Xiaoyong , Yao Ruobing , Liu Biyong , Hu Haichuan , Xu Zichen , Tan Shuang , Tan Yusong , Xu Chenren 
Published: June 2022

Abstract
The high flexibility of microservice architecture provides notable divergence among the internal software stack within the same application. Microservice-based application are commonly deployed in data center from users yet they have no cue where or what existly are provided from the service provider. In this case, there could exist those providers could be able to replace the internal software without noticing, making a contract level fault and offloading risks to users. To better profile the microservice, we propose a framework that provides non-intrusive measurements on microservice inference, or MEME, to detect fraudulent behaviors of cloud service providers on microservice-based applications. We design MEME using performance portrait and fast Fourier transform (FFT). We model the microservice-based application with a set of cohorts and use FFT to obtain the signal formed by the main frequency components of average response time. Our model represents the performance portrait of the microservice-based application. The performance portrait is similar to a fingerprint that Nonintrusive Measurement of Microservice Inferences carries internal software information. In our experiments, we take a two-tier microservice-based application containing databases as an example. Empirical results show that MEME can provide a distinguishable profile of the performance portrait of data services in a temporal and spatial manner, which allows us to identify the software type.
Digital Health Technologies During COVID-19: A New Normal in Primary Health Care Delivery
Authors: Ndayishimiye Costase , Lopes Henrique , Middleton John 
Published: June 2022

Abstract
The primary health care (PHC) in the Alma-Ata Declaration of 1978, revisited in the Astana Declaration of 2018, underpins the fundamental goal of achieving universal healthcare coverage. The 2019 coronavirus pandemic (COVID-19) shows that rapidly spreading outbreaks can significantly hamper the provision of PHC. This study investigates how digital health technologies (DHTs) evolved to support the PHC sector during COVID-19 and lessons for the future improvement of PHC. A systematic review was conducted through database searches (PubMed, Scopus, and Google Scholar) and hand-searching of grey documents published in English between December 2019 and December 2021. The study employed thematic content analysis and synthesis. The final synthesis included 46 documents: 40 articles; one book; two book chapters; one working paper; and two technical reports. Around 19 major theme categories were found, with the top three being the eHealth category, comprising themes like telemedicine, e-prescription, telepsychiatry, and telehealth visits; the mHealth category, such as App-based telemedicine and mobile electronic patient records connecting patients, physicians, and health systems; and the device category, such as wearable technologies, telemedical stethoscopes, telemedical ECGs, and remote monitoring devices. Finally, 20 areas of use of DHTs were identified and then grouped into five main areas: 1st) provision of health services, such as general care (teleconsultations, diagnosis, testing, etc.) and managing chronic conditions; 2nd) communicating, informing, and educating roles (e.g., preventing vaccine hesitancy) and digital health literacy; 3rd) monitoring and surveillance roles (e.g., symptoms’ monitoring); 4th) vaccination and drug purposes (e.g. e-prescription, adverse-drug-reaction monitoring, etc.); and 5th) enhancing system decision-making. DHTs have the potential to solve some of the challenges that have plagued us even before COVID-19. Therefore, this study puts forward recommendations to further stimulate the use of evidence based DHT, making it more inclusive, educative, and satisfying to people's needs, both under normal conditions and during outbreaks. More research is required, with a focus on quality assurance in the use of digital health; technical aspects (standards for digital health tools, infrastructure, and platforms); and financial perspectives (payment for digital health services and adoption incentives).
Causes and treatment strategies of unilateral leaflet shedding of bileaflet mechanical prosthetic heart valves after surgery
Authors: Wang Xianzhi , QIU Jiawei , MU Cunfu , ZHANG Wenlin , XUE Chunzhu , HE Yang , MU Qinglin , FU Chunyang , LI Dianyuan 
Published: June 2022

Abstract
Objective: Unilateral leaflet shedding is a rare complication. This paper discusses the causes and treatment strategies of unilateral leaflet shedding of bileaflet mechanical prosthetic heart valves after surgery. Methods: This study was a retrospective study that included 1 case of unilateral leaflet shedding after mechanical valve replacement of the aortic valve in Fuwai Hospital in 2010 and 1 case of unilateral leaflet shedding after mechanical valve replacement of the mitral valve in the First People’s Hospital of Guangyuan in 2021. The new mechanical valves were replaced during subsequent surgeries. data were collected, and the patients were followed up for 10 years and 3 months after the operations, respectively. Results: The patient with an aortic valve replacement was a male; the patient with a mitral valve replacement was a female; and they had an average STS risk score of 3.9%. Both patients had severe regurgitation, and the results of the reoperations were satisfactory. After the operations, the echocardiograms showed that there was no regurgitation in either of the valve replacements. There were no changes in the ankle-brachial index (ABI) before and after the operation in either of the two patients, and no complications or deaths occurred during follow-up. Conclusion: The reason for the leaflet sheddings may be related to the valve design and the leaflet materia. If the detached leaflets are damaged and if the distal blood vessels are affected, simultaneous surgical treatment is required. Those patients whose vessels were not damaged by the valve lobe should be carefully monitored.
A study to assess the decision making power regarding postnatal diet, exclusive breast-feeding and family planning methods among postnatal women in selected rural communities of West Bengal
Authors: Maji Riku 
Published: June 2022

Abstract
A descriptive study was conducted to assess the decision making power regarding postnatal diet, exclusive breast feeding and family planning methods among postnatal women in selected communities of West Bengal. The conceptual framework was based on women autonomy which is adopted from the study “Women’s’ autonomy and reproductive healthcare-seeking behaviour” conducted in Ethiopia by Yohannes Dibaba Wado. Population was postnatal women who had children of six months of age group.. 180 samples were taken from the rural communities under Kelejora B.P.H.C. A validated and reliable structured interview schedule was used to assess the decision making power of postnatal women regarding postnatal diet, exclusive breast feeding and family planning methods. The findings of the study revealed that most of postnatal women ÷(97.8%) had strong decision making power in exclusive breast feeding whereas only 31.1% postnatal women had strong decision making power in family planning methods. Majority of (76.1%) postnatal women had strong decision making power regarding postnatal diet. Statistically significant association was observed between decision making power of postnatal women regarding postnatal diet and religion (÷2 = 12.0742, at df 4) at 0.05 level of significance. In the area of exclusive breast feeding there was significant association between decision making power regarding exclusive breast feeding and religion (÷2 = 23.28, at df 2) at 0.05 level of significance. There was statistical significant association between decision making power of postnatal women regarding family planning methods and age of women(÷2 = 17.7, at df 2) and parity of women (÷2 = 6.97, at df 2) at 0.05 level of significance. The study has a great implication in Nursing service, education, research and administration. Based on the findings the recommendation is made for a study to find out knowledge and practice regarding postnatal diet, exclusive breast feeding and family planning methods. It is concluded that the magnitude of women’s decision making power on postnatal diet and exclusive breast feeding is high in this study whereas the decision making power regarding family planning methods among postnatal women is very low.
Using Verbal Behavior Transfer Procedures to Increase Phonological Awareness
Authors: Reed Nathan , Kerr Madison 
Published: June 2022

Abstract
Verbal behavior is used when programming instruction for students with Autism to increase language repertoires and motivation to communicate. However, using verbal behavior to provide academic instruction is used less frequently. Reading is defined as the textual operant in Skinner’s 1957 analysis. The skills which lead to textual behavior such as phonological awareness have not received the attention that other non-verbal stimuli have received as an antecedent for evoking tacts. The current research uses ABAB design to determine the effectiveness of using verbal behavior transfer procedures to teach phonological awareness. · Echoic to Tact Transfer provides errorless phonological instruction.· Explicit 1:1 instruction with scheduled reinforcement was used.· Students possessed both an echoic and tact repertoire.· Sessions included target stimuli and previously mastered stimuli for instruction.
Relativistic effect inside matter. Obtaining a new dispersion formula.
Authors: Chernov Andrey 
Published: June 2022

Abstract
The main prerequisite for this study was the external similarity of such physical processes as the refraction of light in a transparent substance and the deflection of light by the gravitational field of massive cosmic bodies. Based on the external similarity, the author put forward a hypothesis about the internal similarity of these two physical processes. This made it possible to integrate Einstein's well-known relativistic formula into the process of light propagation in electron clouds (fields) of a transparent substance. As a result of the transformations carried out, a new physical dispersion formula with a wide spectrum of action was obtained from the Einstein formula. According to the new dispersion formula, 26 refractive indices of light were calculated in 5 transparent substances in 3 states of aggregation. Comparison of the obtained indicators with laboratory indicators showed the high accuracy of the new physical formula, which amounted to ±10 -7−10 -5 in the calculated sections of the wave ranges over 100 nm. The successful application of the relativistic formula to the process of light refraction in transparent substances indicates that relativistic effects are present at the atomic-molecular level.