bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family literacy practices and their contribution to emergent literacy skills during the COVID-19 pandemic
Authors: Cruz Joana , Mackaaij Maria , Bilimória Helena , Gandra Daniela 
Published: December 2022

Abstract
To develop emergent literacy skills, preschool children need to be supported by adults in a rich and stimulating
environment. During the first lockdown due to the SARS-CoV2 virus, there were several social, family, technological, and
individual barriers to promote family literacy and emergent literacy. In the present study, we aimed to provide insight on the
relationship between family literacy practices and emergent literacy skills among preschool children after the first confinement
due to COVID-19 pandemic. This study included 102 participants, which consisted of parents (90.2% mothers) and one preschool child
per parent. Results showed evidence of a higher frequency of training and teaching activities than family literacy playful
activities. There were statistically significant differences in emergent skills, according to the frequency of family playful
activities and family training and teaching activities. Results suggest that different family literacy practices are significantly
correlated to all the emergent literacy skills evaluated.
The contribution of full tone marking to oral reading fluency and comprehension in Yoruba and Ife
Authors: Roberts David , Harley Matthew , Walter Stephen L. 
Published: December 2022

Abstract
Orthographic depth is a key concept in literacy acquisition and can be measured separately for completeness, simplicity and
consistency. The first of these is pertinent to discussions about whether tone should be marked in African
orthographies, because a zero tone representation is relatively incomplete and deep whereas a full tone orthography is relatively
complete and shallow. We undertook a series of literacy experiments in ten Niger-Congo languages to test the extent to which full
tone marking contributes to reading and writing skills. In a within-subject design that closely follows Bird (1999b), participants orally read two full tone and two zero tone texts and also added tone accents
to unmarked versions of two of the texts. Speed, accuracy, comprehension, as well as a range of linguistic, ethno-literacy,
demographic and L2 literacy variables were tracked. The present article narrows the scope of the wider research project (Roberts & Walter 2021) to two of the languages, Yoruba and Ife, which are
linguistically similar, yet have highly dissimilar results. In Yoruba, full tone marking does not contribute to any improvement in
reading measurements, and tone writing skills are generally poor. In Ife, on the other hand, full tone marking contributes to
speed, accuracy and comprehension, and tone writing is the most accurate of all the languages. The results suggest that the social
profile of the participant and the ethno-literacy profile of the language community are more predictive of reading and writing
performance than is the linguistic profile of the language.
From a single silicon carbide detector to pixelated structure for radiation imaging camera
Authors: Zat'ko B. , Šagátová A. , Gál N. , Novák A. , Osvald J. , Boháček P. , Polansky Š. , Jakůbek J. , Kováčová E. 
Published: December 2022

Abstract
In this work, Schottky detectors based on a high-quality 4H-SiC epitaxial layer with a thickness of 50 µm were prepared. The Schottky contact of Ni/Au metallization with a 3 mm diameter was made. Reverse current-voltage characteristics were measured up to a voltage of 300 V with a leakage current of 40 pA at room temperature. Using an α-particle radiation source, the spectrometric characteristics of the 4H-SiC detector were tested. The best energy resolution in the FWHM (Full Width and Half Maximum) about 15 keV for 5.5 MeV α-particles was observed. Furthermore, a 4H-SiC pixel sensor (256 × 256) for the Timepix3 reading chip was prepared. The spectrometric and imaging properties of the new Timepix3 detector based on the 4H-SiC sensor were tested. The results showed high energy resolution and also high-quality X-ray imaging of the biological object.
Basic Consideration for Facial Aging: Age-Related Changes of the Bony Orbit and Orbicularis Oculi Muscle in East Asians
Authors: Okuda Itsuko , Akita Keiichi , Komemushi Takayoshi , Imaizumi Kazuhiko , Jinzaki Masahiro , Ohjimi Hiroyuki 
Published: December 2022

Abstract

Background
Age-related changes in the periocular areas are mainly caused by anatomic changes of the bony orbit and orbicularis oculi muscle (OOM). To achieve effective rejuvenation, it is necessary to understand the age-related aspects of these anatomic changes.

Objectives
The aim of this study was to analyze the configuration of the bony orbit and OOM with computed tomography (CT) and to evaluate the effects of aging on these structures.

Methods
A total of 220 orbits and OOMs of 110 Japanese participants (55 males, 55 females) aged 20 to 87 years were enrolled. The long diameter of the orbits, orbital ellipticity, OOM thickness, and OOM attachment to the inferior orbital rim were analyzed. These variables were statistically evaluated for their relationship with age.

Results
The long diameter of the orbit was significantly longer in those over than in those under 60 years, with a moderate and significant positive correlation between orbital ellipticity and age. OOM thickness and age showed a strong negative correlation. The degree of OOM attachment to the inferior orbital rim decreased significantly with age.

Conclusions
This study showed that age-related changes of the bony orbit in Japanese individuals tended to be the same as those in Caucasians, but there were differences in the degree of changes observed. As a new finding in the Japanese population, the OOM not only thins with aging, but also gradually loosens from the facial bone. In the elderly, only the nasal side of the OOM was attached to the bone. In clinical applications, this knowledge could contribute to the development of cosmetic surgeries.
Blowup of Dyadic MHD Models with Forward Energy Cascade
Authors: Dai Mimi 
Published: December 2022

Abstract
A particular type of dyadic model for the magnetohydrodynamics (MHD) with dominating forward energy cascade is studied. The model includes intermittency dimension $\delta $ in the nonlinear scales. It is shown that when $\delta $ is small, positive solution with large initial data for either the dyadic MHD or the dyadic Hall MHD model develops blowup in finite time. Moreover, for a class of positive initial data with large velocity components and small magnetic field components, we prove that there exists a positive solution that blows up at a finite time.
Mutation of the polyadenylation complex subunit CstF77 reveals that mRNA 3′ end formation and HSP101 levels are critical for a robust heat stress response
Authors: Kim Minsoo , Swenson John , McLoughlin Fionn , Vierling Elizabeth 
Published: December 2022

Abstract
Heat shock protein 101 (HSP101) in plants, and bacterial and yeast orthologs, is essential for thermotolerance. To investigate thermotolerance mechanisms involving HSP101, we performed a suppressor screen in Arabidopsis thaliana of a missense HSP101 allele (hot1–4). hot1–4 plants are sensitive to acclimation heat treatments that are otherwise permissive for HSP101 null mutants, indicating that the hot1–4 protein is toxic. We report one suppressor (shot2, suppressor of hot1–4 2) has a missense mutation of a conserved residue in CLEAVAGE STIMULATION FACTOR77 (CstF77), a subunit of the polyadenylation complex critical for mRNA 3′ end maturation. We performed ribosomal RNA depletion RNA-Seq and captured transcriptional readthrough with a custom bioinformatics pipeline. Acclimation heat treatment caused transcriptional readthrough in hot1–4 shot2, with more readthrough in heat-induced genes, reducing the levels of toxic hot1–4 protein and suppressing hot1–4 heat sensitivity. Although shot2 mutants develop like the wild type in the absence of stress and survive mild heat stress, reduction of heat-induced genes and decreased HSP accumulation makes shot2 in HSP101 null and wild-type backgrounds sensitive to severe heat stress. Our study reveals the critical function of CstF77 for 3′ end formation of mRNA and the dominant role of HSP101 in dictating the outcome of severe heat stress.
Gamma Radioactivity Detection Limits and Associated Radionuclide Intakes Study in Artificial Human Urine Using Sodium-iodide and High-purity Germanium Detectors
Authors: Burn Adam G. , Haines Douglas K. , Khan Abdul J. , Torres Miguel A. , Faye Sherry A. , Costello Cynthia A. , Hoffman Timothy J. , Chu Liang T. , Bradt Clayton J. , Semkow Thomas M. 
Published: December 2022

Abstract
The performance of several gamma detectors was investigated for emergency urine bioassay screening of two radionuclides of concern: 131I and 137Cs. Unspiked artificial urine samples were measured for 10 min each on four different gamma detectors: 80% relative efficiency high-purity Ge detector in standard shielding, 102% low-background high-purity Ge detector equipped with top muon shield, 78% high-purity Ge well detector in standard shielding, and 4″ × 4″ NaI well detector in standard shielding. The measured gamma spectra were analyzed in two ways: (1) for the 364-keV peak region of 131I and 662-keV peak region of 137Cs and (2) for the total counts in the full energy spectrum (50-2,048 keV). The results were analyzed using the principles of signal detection theory according to the Currie’s formalism extended by a complete uncertainty propagation. This enabled calculation of the detection capability in terms of detection limit (Bq L−1) of urine, the latter referred to as minimum detectable activity. The NaI well detector had the lowest minimum detectable activities for total spectra, whereas the high-purity Ge well detector had the lowest peak minimum detectable activity values. Minimum detectable inhalation and ingestion intakes from urine bioassay were calculated from the minimum detectable activity values for urine collection 1 d, 1 wk, and 1 mo past the initial intake. The calculated intakes were compared with annual limits on intake. The results are interpreted with respect to a large-scale radiological emergency response.
Parental Participation in Preterm Infant Feeding in the Neonatal Intensive Care Unit
Authors: Nist Marliese Dion , Robinson Audrey , Pickler Rita H. 
Published: December 2022

Abstract

Purpose:
To identify factors associated with parental participation in the feeding care of hospitalized preterm infants and determine associations between parental participation in feeding and infant neurobehavioral outcomes.

Study Design and Methods:
Secondary analysis of data collected during a larger study of preterm infants. Parental participation in gavage and oral feeding was measured as a proportion of all feeding opportunities. Neurobehavioral outcomes were measured using a neurobehavioral assessment and feeding milestones. Other data were collected from the electronic health record.

Results:
Parental participation in feeding was low. There were associations between parental participation in gavage feeding and infant sex, insurance type, maternal race, infant gestational age at birth, and birthweight. There were associations between parental participation in oral feeding and infant sex, insurance type, maternal race, and study group. Greater parental participation in feeding was associated with earlier achievement of some feeding milestones.

Clinical Implications:
Parental participation in feeding can decrease the time required for infants to achieve feeding milestones, possibly leading to decreased length of hospitalization. Nurses should encourage parents to participate in caregiving for their preterm infants. Interventions are needed to remove barriers to parental participation in caregiving.
A New Magnetic Resonance Imaging Method for 2 Tissue Suppression: Double Tissue Suppression With Multiecho Acquisition and Single Inversion Time Combining High-Intensity Reduction (DOMUST-HIRE)
Authors: Sakoda Kazuya , Baba Shogo , Nakazono Rena , Maekawa Yui , Kuroki Yuta 
Published: December 2022

Introduction
The fluid-attenuated inversion recovery (FLAIR) method is one of the most important magnetic resonance imaging techniques for the brain, and the high-intensity reduction (HIRE) method is an imaging technique to obtain cerebrospinal fluid suppression images by subtracting long echo time images from short echo time images. In contrast, the double inversion recovery technique suppresses 2 types of tissue signals with different T1 values by applying 2 inversion recovery pulses with different inversion times. However, the double inversion recovery method requires the setting of 2 inversion times in a sequence; thus, its use is limited to relatively high-specification equipment. Here, we propose a new sequence called double tissue suppression with multiecho acquisition and single inversion time combining high-intensity reduction (DOMUST-HIRE) that suppresses the 2 tissues by adding single inversion recovery pulses to a sequence based on the HIRE method.

Methods
In this small clinical study, we performed physical evaluation by imaging a subject's head with FLAIR and DOMUST-HIRE method.

Results
The DOMUST-HIRE method can increase the contrast ratio and the contrast-to-noise ratio between white matter (WM) and gray matter, whereas the signal-to-noise ratio between WM and gray matter decreased than with FLAIR method.

Conclusions
The DOMUST-HIRE method can be used to suppress WM and cerebrospinal fluid signals.
Relative Impact of Pain and Disease Activity on Improvements in Fatigue
Authors: Fautrel Bruno , Wu Jianmin , Wang Duzhe , Haladyj Ewa , van de Laar Mart A. F. J. , Takeuchi Tsutomu 
Published: December 2022

Abstract

Background/Objective
Fatigue is common in patients with rheumatoid arthritis (RA). We assessed the relative impact of pain and disease activity on improvements in fatigue in 2 phase 3 baricitinib clinical trials.

Methods
RA-BEAM (NCT01710358) and RA-BEACON (NCT01721044) were randomized, double-blind, placebo-controlled studies in adults with moderate to severe RA. RA-BEAM assessed baricitinib + methotrexate (MTX) and adalimumab + MTX in patients with prior inadequate response/intolerance (IR) to MTX (MTX-IR). RA-BEACON assessed patients with IR to ≥1 biologic disease-modifying antirheumatic drug (bDMARD-IR). Measures included the Functional Assessment of Chronic Illness Therapy—Fatigue scale, Clinical Disease Activity Index (CDAI) for RA, and pain visual analog scale (VAS). Analyses were implemented separately for each study.

Results
Significant improvements were seen in disease activity and pain, which were greater with baricitinib versus adalimumab. A statistically significant improvement was seen in fatigue with both active treatments versus placebo. Moderate correlations were observed between improvements in disease activity and fatigue and between improvements in pain and fatigue in both MTX-IR and bDMARD-IR patients. Reductions in pain (≥50%) and remission or low disease activity (CDAI ≤10) had significant associations with fatigue improvement at week 24. In mediation analysis, improvements in fatigue attributable to CDAI and pain VAS in MTX-IR patients were 31% and 52%, respectively, for baricitinib, and 30% and 47%, respectively, for adalimumab. In bDMARD-IR patients, improvement in fatigue was attributed 48% to CDAI and 48% to pain VAS.

Conclusions
In both MTX-IR and bDMARD-IR patients, a large proportion of improvements in fatigue across treatment arms were accounted for by improvements in pain and disease activity.
Deep learning application to automatic classification of pharmacist interventions
Authors: Alkanj Ahmad , Godet Julien , Johns Erin , Gourieux Bénédicte , Michel Bruno 
Published: December 2022

ABSTRACTBackgroundPharmacist Interventions (PIs) are actions proposed by pharmacists during the prescription review process to address non-optimal drug use. PIs must be triggered by drug-related problems (DRP) but can also be recommendations for better prescribing and administration practices. PIs are produced daily text documents and messages forwarded to prescribers. Although they could be used retrospectively to build on safeguards for preventing DRP, the reuse of the PIs data is under-exploited.ObjectiveThe objective of this work is to train a deep learning algorithm able to automatically categorize PIs to value this large amount of data.Materials and MethodsThe study was conducted at the University Hospital of Strasbourg. PIs data was collected over the year 2017. Data from the first six months of 2017 was labelled by two pharmacists, who manually assigned one of the 29 possible classes from the French Society of Clinical Pharmacy classification. A deep neural network classifier was trained to learn to automatically predict the class of PIs from the processed text data.Results27,699 labelled PIs were used to train and evaluate a classifier. The accuracy of the prediction calculated on the validation dataset was 78.0%. We predicted classes for the PIs collected in the second half of 2017. Of the 4,460 predictions checked manually, 67 required corrections. These verified data was concatenated with the original dataset to create an extended dataset to re-train the neural network. The accuracy achieved was 81.0 %, showing that the prediction process can be further improved as the amount of data increases.ConclusionsPIs classification is beneficial for assessing and improving pharmaceutical care practice. Here we report a high-performance automatic classification of PIs based on deep learning that could find a place in highlighting the clinical relevance of the drug prescription review performed daily by hospital pharmacists.
Perception and knowledge of artificial intelligence in healthcare, therapy and diagnostics: A population-representative survey
Authors: Wittal Cornelius G. , Hammer Doerte , Klein Farina , Rittchen Joachim 
Published: December 2022

AbstractArtificial intelligence (AI) is understood as a system’s ability to correctly interpret and learn from data, and to achieve specific goals and tasks through flexible adaptation to those learnings. Despite a broad range of available applications for artificial intelligence in medicine, healthcare professionals are reluctant to implement AI-powered devices. Data on the perception of medical AI in the German general public are currently rare. Therefore, two online surveys were conducted in 2021 in Germany to assess knowledge and perception of artificial intelligence in general and in medicine, including the handling of data in medicine. A total of 1,001 and 1,000 adults, respectively, participated in the surveys. The survey results stress the need to improve education and perception of medical AI applications by increasing awareness, highlighting the potentials, and ensuring compliance with guidelines and regulations to handle data protection. This survey provides first insights into this relevant topic within the German population.
Cost-effectiveness analysis comparing repetitive transcranial magnetic stimulation therapy with antidepressant treatment in patients with treatment-resistant depression in Japan
Authors: Noda Yoshihiro , Miyashita Chiaki , Komatsu Yoko , Kito Shinsuke , Mimura Masaru 
Published: December 2022

AbstractBackgroundIn Japan, repetitive transcranial magnetic stimulation (rTMS) for patients with treatment-resistant depression (TRD) became covered by the National Health Insurance (NHI) in 2019. While the usefulness of rTMS for TRD has been established, the cost-effectiveness of rTMS versus antidepressants has not been thoroughly analyzed in Japan. This study aimed to evaluate the cost-effectiveness of rTMS for TRD under the NHI system.MethodsCost-effectiveness of rTMS versus antidepressants was analyzed using a microsimulation model to compare the direct costs and quality-adjusted life years (QALYs) in patients with moderate to severe depression who had failed one or more antidepressants over their lifetime. Model inputs of clinical parameters and the utility were derived from published literature. Cost parameters were estimated from the Japanese Claim Database. In addition, the robustness of the analysis results was evaluated using sensitivity analysis and scenario analysis.ResultsThe analysis estimated that rTMS increased effectiveness by 0.101QALYs and total cost by ¥94,370 ($689) compared with antidepressant medications. As a result, the incremental cost-effectiveness ratio (ICER) of rTMS was estimated to be ¥935,984 ($6,832)/QALY. In the sensitivity and scenario analyses, ICER did not exceed ¥5 million ($36,496)/QALY as the reference value of the Japanese public cost-effectiveness evaluation system.LimitationsFor the portion of the rTMS for which data were not available under the NHI system in Japan, foreign data and estimates were extrapolated.ConclusionsrTMS showed the potential to be a cost-effective treatment strategy for TRD compared with antidepressants under the NHI system in Japan.
Common predators and factors influencing their abundance inAnopheles funestusaquatic habitats in rural south-eastern Tanzania
Authors: Mahenge Herieth H. , Muyaga Letus L. , Nkya Joel D. , Kifungo Khamis S. , Kahamba Najat F. , Ngowo Halfan S. , Kaindoa Emmanuel W. 
Published: December 2022

AbstractBackgroundThe role that larval predators play in regulating the population of malaria vectors remains relatively unknown. This study aimed to investigate the common predators that co-exist withAnopheles funestusgroup larvae and evaluate factors that influence their abundance in rural south-eastern Tanzania.MethodsMosquito larvae and predators were sampled concurrently using standard dipper (350 ml) or 10 L bucket in nine villages in southern Tanzania. Predators were identified using standard identification keys. All positive habitats were geo-located and their physical features characterized. Water physicochemical parameters such as dissolved oxygen (DO), pH, electrical conductivity (EC), total dissolved solids (TDS) and temperature were also recorded.ResultsA total of 85 previously identifiedAn. funestusaquatic habitats were sampled for larvae and potential predators. A total of 8,295 predators were sampled. Of these Coenagrionidae 57.7% (n=4785), Corixidae 12.8% (n=1,060), Notonectidae 9.9% (n=822), Aeshnidae 4.9% (n=405), Amphibian 4.5% (n=370), Dytiscidae 3.8% (n=313) were common. A total of 5,260 mosquito larvae were sampled, wherebyAnopheles funestusgroup were 60.3% (n= 3,170),Culexspp. 24.3% (n= 1,279),An. gambie s.l. 8.3% (n= 438) and other anophelines 7.1% (n= 373). Permanent and aquatic habitats larger than 100m2were positively associated withAn. funestusgroup larvae (P<0.05) and predator abundance (P<0.05). Habitats with submerged vegetation were negative associated withAn. funestusgroup larvae (P<0.05). Only dissolved oxygen (DO) was positively and significantly affect the abundance ofAn. funestusgroup larvae (P<0.05). While predators abundance were not impacted by all physicochemical parameters.ConclusionSix potential predator families were common in aquatic habitats ofAn. funestuslarvae group. Additional studies are needed to demonstrate the efficacy of different predators on larval density and adult fitness traits. Interventions leveraging the interaction between mosquitoes and predators can be established to disrupt the transmission potential and survival of theAn. funestusmosquitoes.