bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerliponase alfa in the treatment of patients with classic and atypical late infantile neuronal ceroid lipofuscinosis in Latin America
Authors: Guelbert Norberto , Segura Oscar M Espitia , Amoretti Carolina , Arteaga Angélica Arteaga , Atanacio Nora G , Bazan Natacha S , Carvalho Ellaine D.F , de Andrade María D. F Carvalho , Denzler Inés M , Durand Consuelo , Ribeiro Erlane M , Giugni Juan C , González Gabriel , Moron Dolores González , Guelbert Guillermo , Rodriguez Zulma J Hernández , Embiruçu Emilia K , Kauffman Marcelo A , Mancilla Nury I , Marcon Laureano , Pereira Alessandra Marques , de Souza Carolina F Fischinger Moura , Muñoz Victor A , Florez Ricardo A Naranjo , Pessoa André L , Ruiz Maria V , Villareal Martha M Solano , Spécola Norma , Tavera Lina M , Tello Javiera , Schifferli Mónica Troncoso , Urgrina Sonia , Vaccarezza María M , Vergara Diane , Villanueva María M 
Published: November 2022

Abstract

Introduction: Late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), is a neurodegenerative autosomal recessive disease caused by TPP1 gene variants, with a spectrum of classic and atypical phenotypes. The aim of treatment is to slow functional decline as early as possible, improving quality of life and survival. This study describes the clinical characteristics as well as response to treatment with cerliponase alfa.
Materials and Methods: A retrospective study was conducted in five Latin-American countries, based on clinical records from patients with CLN2. Clinical follow-up and treatment variables are described. A descriptive and bivariate statistical analysis was performed.
Results: A total of 36 patients are reported with a mean age of symptom onset and time to first specialized consultation of 4.7±2.3 and 6±3.1 years, respectively. Seizures were the predominant symptom (80.6%). In a subgroup analysis, most patients with the classic phenotype exhibited regression in language (90%), while the patients with the atypical phenotype had seizures as the predominant symptom (87%). The mean age of symptom onset and time to first specialized consultation was 3.5±2.0 and 4.9±3.2 years, respectively, in patients with the classic phenotype and 6.2±1.8 and 7.5±2.4 in patients with the atypical phenotype. The mean time interval between onset of symptoms and treatment initiation was 3.8 years in patients with classic phenotype and 7.4 in patients with atypical phenotype. All patients were treated with cerliponase alfa, maintaining overall functional stability as compared to pretreatment values.
Discussion and conclusion: This study reports at this time the largest number of patients with CLN2 in treatment with cerliponase alfa in the world. Data show a higher frequency of patients with atypical phenotype and a high allelic proportion of intron variants in our region. There was evidence of long intervals until first specialized consultation, diagnosis, and enzyme replacement therapy. Follow-up after the initiation of cerliponase alfa showed slower-to-no-progression of the disease, associated with adequate clinical outcomes and stable functional scores. These improvements were consistent in both clinical phenotypes.
Skill-biased Technical Change and Intergenerational Education Mobility
Authors: Aziz Imran 
Published: November 2022

Abstract
This paper analyzes the impact of skill-biased technological change (SBTC) on intergenerational education mobility. I set up an SBTC model with an overlapping generations framework, where heterogeneously-skilled households invest in their children's education to make them skilled. Technology incentivizes these investments by creating both pecuniary (higher skill-premium) and non-pecuniary (improved life skills) benefits; it constrains investments among low-income households by increasing inequality. I show there is a critical technology range within which SBTC shocks can increase investments by both high-income and low-income households, improving absolute education mobility. Moreover, the relative increase in transfers can be larger for the low-income group who initially have lower investment levels, which can help their children catch-up. I test the predictions of the model using data from Chetty et al. (2014) which show how college attendance rates of children in U.S. commuting zones (CZs) are linked to the rank of their families in the national income distribution. A technology measure is constructed for each CZ using its share of STEM workers, which I instrument using a Bartik-type IV to deal with endogeneity concerns. From 2SLS estimations, I find that college attendance rates of children from households in the same income rank improve if households are located in higher technology CZs, with the improvement being larger among lower-ranked households. Thus, SBTC is found to improve both absolute and relative intergenerational education mobility.
JEL Codes: J24, J31, J62, I24, O33
Behavioural hormoligosis in oviposition preference of Bemisia tabaci Gennadius on egg plant
Authors: Dumra Neeru , Rolania Krishna , Yadav Surender Singh , Mandhania Shivani 
Published: November 2022

Abstract

The study tests the impact of sublethal dose on oviposition preference in Bemisia tabaci (Gennadius) on treated brinjal plant using the multiple-choice test during 2019 and 2020 season. Diafenthiuron 50% WP (150, 210, and 300 g a.i./ha), fenpropathrin 30% EC (50, 70, and 100 g a.i./ha), thiamethoxam 25% WG (25, 35 and 50 g a.i./ha) and deltamethrin 2.8% EC (7.5, 10.5 and 15 g a.i./ha) were repeatedly sprayed on brinjal plants (var. Hisar Shyamal) growing in pots. The effectiveness of these insecticides was assessed based on the preference of B. tabaci (whitefly) for oviposition on treated plants. Additionally, this study tested variations in the biochemical components of treated brinjal leaves and their relationship to the propensity for oviposition. The results revealed that fenpropathrin 30% EC and deltamethrin 2.8% EC treated plants were more preferred by whitefly for oviposition. Maximum number of eggs were laid on sublethal dose of fenpropathrin30% EC treated plants at 50 g a.i./ha (42.93 eggs/ leaf) and deltamethrin 2.8% EC at 7.5 g a.i./ha (39.57 eggs/leaf) followed by fenpropathrin30% EC at 70 g a.i./ha (39.02 eggs/ leaf) compared to untreated control (26.74 eggs/leaf). An almost similar trend of results was observed in the repeated experiment in 2020. The results obtained from biochemical studies revealed that all the insecticidal treatments caused a reduction in total sugars and amino acids except lower dose of fenpropathrin 30% EC, and deltamethrin 2.8% EC. Also, all the insecticides caused a reduction in total phenol content and brought significant changes in crude protein content. Hence, fenpropathrin 30% EC and deltamethrin 2.8% EC treated brinjal plant is nutritionally superior host for whitefly and led to behavioural hormoligosis in oviposition preference by whitefly. The results of this study would benefit agricultural practitoners and farmers.
Self-rationing and small business success: the moderate role of informal finance
Authors: ERIOLA Jesse Akitola , HOUNKOU Emmanuel Cossi 
Published: November 2022

Abstract
This study investigates the relationship between small business success and formal finance self-rationing by highlighting the moderate effect of informal financing. A structural equation method is realized using questionnaire survey data from a sample of 293 Beninese small business managers. Overall, the study shows that the majority (more than 65%) of small businesses are self-rationed. Almost 40% of respondents have got financing support from their family or friends and about 38% apply for tontine. Additionally, we find that self-rationing negatively and significantly affects small business success. We also find that informal financing moderates the relationship between self-rationing and small business success. Thus, When the managers perceive more guarantees required, high costs, and difficulties in the application process for formal financing, they use informal funding to overcome these difficulties to reach success. Furthermore, our findings suggest that the government should target and organize informal financing, especially tontine. Formal institutions especially banks are to consider interpersonal factors to facilitate the financing conditions for small businesses instead of always focusing their attention only on the classic process to resolve the higher cost of financing problem and reduce the asymmetric information problem.
Value Chain Hygiene Practices and Microbial Contamination of Street and Market Vended Ready-to-Eat grasshopper, Ruspolia differens in Uganda: Implications for food safety and public health
Authors: Rutaro Karlmax , Hawumba Joseph , Nakimuli Jane , Mulindwa Julius , Malinga Geoffrey M. , Baingana Rhona 
Published: November 2022

Abstract
Background
Food safety is a major public health issue, particularly in developing countries. Ready-to-eat street-vended foods contribute to daily dietary life, but with elevated food safety burden. Here, hygiene and food safety practices as well as the microbial contamination in Uganda's edible grasshopper value chain was evaluated.
Methods
This was a cross-sectional mixed methods study with both qualitative and quantitative approaches. A face-to-face administered questionnaire and observational checklists were used to collect data. A total of 29 households (Kampala; 12 and Masaka; 17) participated, and grasshopper samples collected along the value chain. Indicator pathogens were analysed using standard microbiological methods.
Results
Sociodemographic characteristics reveal that two-thirds of households in Kampala and 53% in Masaka were female headed. In Kampala and Masaka, respectively, 50% and 12% of households had earth or sand floors. All households in Kampala were one or two-roomed dwellings with no separate room as a kitchen, and shared a toilet compared to 43%, 65% and 53%, respectively, in Masaka. 83% households in Kampala and 56% in Masaka obtained drinking water from public taps. Handwashing was inadequate and none of the actors was observed to wash their hands after taking a break or handling waste. Only 8.3% respondents had raised racks for drying utensils. For vendors, wearing protective clothing was not common, with only 28.5% in Kampala and 30.8% in Masaka wearing an apron. Containers for vending grasshoppers were largely uncovered and the utensils (spoon or cup) for measuring the grasshoppers were left mainly uncovered during the observation period. Indicator organisms, E. coli and Salmonella typhimurium, were detected. E. coli was the most common contaminant, but with lower levels in Masaka compared to Kampala. Salmonella typhimurium was mainly a burden in Kampala.
Conclusions
Our findings demonstrate that there are enormous contributors to poor hygiene and sanitation along the value chain. The existence of pathogenic bacteria such as E. coli in ready-to-eat foods imply that their consumption pose a health risk. There is an urgent need to create awareness among the actors,through regular trainings on food safety and personal hygiene practices in food handling and inspection to prevent foodborne disease outbreaks.
Optimization of land suitability evaluation, using fuzzy analytic hierarchy process(FAHP) base on parametric evaluation method
Authors: Hoseini Yaser 
Published: November 2022

Abstract
New irrigation field assessment strategies can be used to improve water use performance in agriculture. In this study, the fuzzy Analysis Hierarchical Process (FAHP) for qualitative soil suitability for drip irrigation is used and compared with conventional parametric approaches. An assessment based primarily on a fully parametric approach identified sites with approximately 2941 hectares (57%) of land to be 'Very Suitable (S1)'. and an area of about 247 hectares (5%) of areas, was “Partly appropriate (S2)” and about 798 hectares (15%) were “Approximately appropriate (S3)”. “Permanently inappropriate (N2)” included about 452 hectares (9%) and “Inappropriate in present condition (N1)” suitability matched 737 hectares (14%) in the study zone. Based on the Fuzzy Analytic Hierarchical Process(FAHP), (S1) suitability included an area of about 2873 hectares (56%) and the parts with (S2) suitability, also included an area of about 2100 hectares (41%). Moreover, areas of about 130 hectares (3%) were “Approximately appropriate (S3)”. Some southwest and west parts of the plain were “Inappropriate in present condition (N1)”, that included an area of about 72 hectares (1%). Also, there were no “Permanently inappropriate (N2)” regions in the plane based on the FAHP method. As a result, there was no significant difference between the two methods in terms of "highly suitable lands”. However, in the fields with (S2) fitness, the differences between the methods are very large, with the FAHP method showing higher field fitness than the conventional parametric method. We point out that FAHP assessment is more accurate than traditional parametric methods of assessing soil suitability, considering the gradual changes in soil properties. Considering the slow changes in the soil-influencing parameters and the variable membership functions of these parameters, and the different weightings of the indices influencing the evaluation, the anomalous influence of the factors on the final characterization was reduced by the FAHP method and the evaluation approaches its true value.
Determinants of household rural poverty in Tenta Woreda, South Wollo Zone, Ethiopia
Authors: Bekele Ayisheshim , kassa Mengesha 
Published: November 2022

Abstract
Poverty in Ethiopia is multidimensional caused by a set of factors ranging from those related to past macro-economic policies and socio-political history of the country. This study examines rural poverty and its determinant at household level. Primary data were collected by using structured questionnaires, interview and focus group discussion. Secondary data also used from different published and unpublished materials. The results are based on the data collected from three selected peasant associations about 196 rural household were taken by simple random sampling. The researcher used Foster Greer-Thorbecke, binary logistic regression model, descriptive statistics and Cost Basic Needs- to find out the determinants of rural poverty at household level. The result of the analysis indicates that poverty status is strongly associated with almost all variables. Household head sex, household family size, and land holding size, oxen and other livestock, small ruminant holding size are significantly important determinants of rural poverty in the study area i.e. households headed by females and big size of the family experience more poverty in the study area. On the other hand, variables such as land, oxen, livestock and small ruminant holding size negatively related with poverty so that households with larger number of land, oxen, livestock and small ruminant are better off than those with smaller number. It is recommended that integrated agricultural research and extension program, family planning, reducing gender based labor division, land distribution and promotion of effecting resettlement program would have indispensable role to reduce poverty in the area.
Revision to the chronology of the early transgressive phase of Lake Bonneville
Authors: Oviatt C. G. 
Published: November 2022

Abstract
Newly available 14C and U-Th ages for microbialites at Death Point (on the shore of Great Salt Lake at Lakeside, UT; Jour Quat Sci 2022) call for a major revision of the Lake Bonneville hydrograph. At the beginning of the Lake Bonneville cycle, the lake experienced an abrupt rise about 30,000 cal yr BP, then dropped back down to levels near the modern elevation of Great Salt Lake, then over the ensuing 6 thousands of years the lake experienced a series of fluctuations, up to levels a few 10s of meters higher than average Great Salt Lake levels then down again. The exact timing and amplitudes of those fluctuations are not known at this time, but importantly the lake did not rise to levels near the Stansbury shoreline until after about 24,000 cal yr BP. Although the Stansbury oscillation(s) occurred during the transgressive phase of Lake Bonneville, not during the regressive phase, as was traditionally thought, the oscillation(s) were younger than 24,000 cal yr BP. This interpretation conflicts with previously published chronologies.
PRKCB is a novel and potential biomarker in colon cancer and shapes an inflamed tumor immune microenvironment
Authors: Wen Su , Zeng Hao , An Kangli , Wu Shuang , Huang Xueqing , Shao Zhuo , Bai Jing , Yin Tiejun 
Published: November 2022

Abstract
Background
Only a small subset of colon cancer patients with mismatch repair deficiency may also benefit from Immune checkpoint inhibitors (ICIs). New biomarkers correlated with ICIs responsiveness need to be explored.
Methods
The study data were obtained from TCGA, GEO, cBioPortal, UALCAN, UCSC Xena browser, and CPTAC databases. Protein kinase C beta (PRKCB) was screened via weighted gene co-expression network analysis (WGCNA), survival analysis and differential expression analysis. The biological and immune landscape of PRKCB was explored by performing bioinformatics and immunohistochemical analyses. These findings were used to predict responsiveness to immunotherapy.
Results
Yellow module in WGCNA, as a hub module, was strongly positively correlated with infiltrated CD8 + T cell and Immune Score. PRKCB was an essential member of the yellow module, downregulated in colon cancer tissue, and associated with poor prognosis. GO, KEGG, REACTOME enrichment analysis showed PRKCB was associated with Cytokine-cytokine receptor interaction, Chemokine signaling pathway, T cell receptor signaling pathway, NF-κB signal pathway, Natural killer cell mediated cytotoxicity, and PD-L1 signaling. Meanwhile, the PRKCB expression was highly positively correlated with the infiltration of the CD4 + T cells, CD8 + T cells, and NK cells. Moreover, the immunohistochemistry analysis of tissue microarray demonstrated that PRKCB expression was positively correlated with infiltrated CD8 + T cell and PD-L1 expression. As expected, the TIDE and SubMap algorithm verified that ICIs could be effective in PRKCB-high patients.
Conclusion
PRKCB-high was associated with good prognoses in colon cancer patients. PRKCB-high was an indicator of inflamed TIME, which correlated with high responsiveness to immunotherapy in colon cancer patients.
Pinocembrin inhibits migration and invasion of non-small cell lung cancer cells by inhibiting STAT3 signaling
Authors: Zhang Jing , Xue Zhiqiang , Wang Bin , Wen Jiaxin , Wang Yunxi 
Published: November 2022

Abstract
Background
STAT3 activation plays a pivotal role in promoting ETM-mediated tumor progression and metastasis and has been considered as a target for the treatment of cancer. Pinocembrin, a natural dihydroxyflavanone found in propolis and honey, has antioxidant and vasodilating properties. In this study, we aim to investigate the role of pinocembrin in inhibiting cells migration and invasion via regulating STAT3 signaling in non-small cell lung cancer cells.
Methods
A549 cells migration and invasion were determined by hematoxylin staining. Relative expression of ETM-related proteins and invasive proteins in A549 cells were determined by western blot. STAT3 activity was evaluated by luciferase assay. Overexpression of STAT3 were used to assess the role of pinocembrin in regulating STAT3.
Results
The number of migrating and invasive cells were significantly reduced by the treatment of pinocembrin. The protein level of E-cadherin was upregulated, and the protein levels of N-cadherin and vimentin were downregulated by pinocembrin. The phosphorylation and activation of STAT3 were blocked by pinocembrin. Overexpression of STAT3 reversed the inhibitory effects of pinocembrin on cells migration and invasion.
Conclusion
Our results suggested that pinocembrin can inhibit STAT3 activation mediated ETM transformation, thereby attenuating migration and invasion in non-small lung cancer cells. Given the significance of STAT3 activation, our findings showed that pinocembrin, by inhibiting STAT3 activation mechanistically, could potentially serve as an effective therapeutic approach for the treatment and management of lung cancer in clinical.
Bounded Rational Bidding Decision for Land Auction in the Context of Real Estate Economic Transformation and Upgrading
Authors: Liao Rujin , Zhang Jing , Tan Ruwen , Wu Yilin , Yu Minjiu 
Published: November 2022

Abstract

Unlike the rapid growth period of China's real estate market, full rational bidding decisions can no longer provide a sufficient theoretical basis for developers’ bidding decisions in land auctions under the transforming and upgrading market. Based on the first-price sealed-bid auction, this paper firstly establishes the standard model where bidders are fully rational, then referring to the research results of behavioral finance, creatively proposes two models under the assumption of bounded rationality of bidders to explain the current situation of the land auction, namely the reference utility model and the Subjective decision probability model. And we analyze the differences between the fully rational assumption model and the bounded rationality assumption models by comparing them. The main conclusions are 1) The assumption of bounded rationality is more consistent with the state of the current market; 2) Land grantors should consider developers' profit margins according to the market background; 3) Under the influence of subjective decisions, the competition of cost advantage developers will intensify while the cost disadvantage developers will be indifferent.
Electrospinning of NH 2 -MIL-88B(Fe)/TiO 2 /PAN (NMTP) nanofiber membranes：photocatalytic degradation tetracycline and efficient oil-water separation applications
Authors: Guo Ruibin , Wang Bingjie , Li Li , Niu Hewen , Guo Wei , Pei Hebing , Chen Qianglong , Liu Nijuan , Mo Zunli 
Published: November 2022

Abstract
Excessive discharge of TC poses a threat to the environment and human health, while finding a cost-effective treatment method to remove TC from water still remains a challenge. In this study, NH2-MIL-88B(Fe)/TiO2/PAN (NMTP) electrospinning nanofibrous membranes (ENMs) were prepared, and the NMTP ENMs were characterized by SEM, XRD, UV-vis and other characterization methods. The results show that the introduction of NH2-MIL-88B(Fe) expands the photoresponse range of ENMs and improves the hydrophilicity of the membranes, NMTP ENMs exhibit excellent photocatalytic performance during the photocatalytic process, and the best sample has excellent photocatalytic performance for TC. The degradation efficiency can reach 93.0%. After 4 times of photocatalytic regeneration, the removal rate still remains about 80%, and its recovery performance is high. The best degradation efficiency of CTC and OTC can reach 94.9% and 86.5%, respectively. In the oil-water separation experiment, the NMTP ENMs exhibited excellent separation performance and high throughput for oil-in-water emulsions, with separation efficiencies of 98.15%, 97.43% and 84.87% for toluene-in-water, n-heptane-in-water and n-hexane-in-water emulsions, respectively. Based on the above results, this study provides a new strategy for developing efficient and stable technologies for simultaneous catalysis and separation of oil-in-water emulsions.