bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluralaner Baits Reduce the Infestation of Peromyscus spp. Mice (Rodentia: Cricetidae) by Ixodes scapularis (Acari: Ixodidae) Larvae and Nymphs in a Natural Environment
Authors: Pelletier Jérôme , Rocheleau Jean-Philippe , Aenishaenslin Cécile , Dimitri Masson Gabrielle , Lindsay L Robbin , Ogden Nicholas H , Bouchard Catherine , Leighton Patrick A 
Published: August 2022

AbstractThe development of interventions that reduce Lyme disease incidence remains a challenge. Reservoir-targeted approaches aiming to reduce tick densities or tick infection prevalence with Borrelia burgdorferi have emerged as promising ways to reduce the density of infected ticks. Acaricides of the isoxazoline family offer high potential for reducing infestation of ticks on small mammals as they have high efficacy at killing feeding ticks for a long period. Fluralaner baits were recently demonstrated as effective, in the laboratory, at killing Ixodes scapularis larvae infesting Peromyscus mice, the main reservoir for B. burgdorferi in northeastern North America. Here, effectiveness of this approach for reducing the infestation of small mammals by immature stages of I. scapularis was tested in a natural environment. Two densities of fluralaner baits (2.1 baits/1,000 m2 and 4.4 baits/1,000 m2) were used during three years in forest plots. The number of I. scapularis larvae and nymphs per mouse from treated and control plots were compared. Fluralaner baiting reduced the number of larvae per mouse by 68% (CI95: 51–79%) at 2.1 baits/1,000 m2 and by 86% (CI95: 77–92%) at 4.4 baits/1,000 m2. The number of nymphs per mouse was reduced by 72% (CI95: 22–90%) at 4.4 baits/1,000 m2 but was not significantly reduced at 2.1 baits/1,000 m2. Reduction of Peromyscus mouse infestation by immature stages of I. scapularis supports the hypothesis that an approach targeting reservoirs of B. burgdorferi with isoxazolines has the potential to reduce tick-borne disease risk by decreasing the density of infected ticks in the environment.
Unclosure: The international law of seabed mining and the systemic cycles of capital accumulation
Authors: Tedeschini Michele 
Published: August 2022

Abstract
The growing electric vehicle industry is heavily reliant on minerals like lithium, cobalt, nickel, and copper. As corporations scramble to access vast deposits of those minerals lying in the ocean floor, the international law of seabed mining has come under scrutiny. This article situates negotiations concerning that law, which took place between 1973 and 1994, within Giovanni Arrighi’s historiographical framework of the systemic cycles of capital accumulation. It argues that the legal regime in question was shaped by the Reagan administration, as part of a strategy to solve a profitability crisis affecting US nationals. While temporarily diverting wealth towards American financial markets, however, the legal arrangements that the United States imposed could not affect the dynamics of capital accumulation on a global scale.
ON GESTATION AND MOTHERHOOD
Authors: Mahmoud Zaina , Romanis Elizabeth Chloe 
Published: August 2022

Abstract
In English law, legal motherhood is allocated to the person who gestated. However, we argue that gestation—legally denoted as the “natural” source of parenting obligations—is often constructed as mothering, rather than the precursor to it. This means that women and pregnant people are treated as mothers prior to birth in legal and medical contexts. Since legal motherhood is an important status, defining the role an individual plays in a child’s life, the conflation of gestation and motherhood does not reflect that, legally, a fetus does not have personhood. This blurring between gestation and motherhood is metaphysically incoherent, as a fetus is not an entity that can be parented. This conflation poses a real harm to pregnant people’s autonomy, specifically those who do not intend to parent or who do not identify as women. More broadly, the medico-legal conflation of gestation and mothering is autonomy-limiting for all pregnant people as, resultantly, they may be coerced into obstetric intervention through legal processes. We argue for a better recognition of the differences between gestation and mothering, to promote autonomy and reflect the very different ways families may be formed.
Very-high-energy flat spectral radio quasar candidates
Authors: Malik Zahoor , Sahayanathan Sunder , Shah Zahir , Iqbal Naseer , Manzoor Aaqib 
Published: August 2022

ABSTRACT
The attenuation of very-high-energy (VHE) photons by the extragalactic background light (EBL) prevents the observation of high-redshift flat spectrum radio quasars (FSRQs). However, the correlation of the VHE spectral index with source redshift suggests that the EBL intensity may be less than what is predicted. This deviation can draw new constraints on the opacity of the Universe to VHE gamma-rays. Therefore, more FSRQs may fall above the sensitivity of the forthcoming VHE telescopes than the ones predicted by the existing EBL models. In order to account for the lower EBL intensity predicted by the index–redshift correlation, we introduce a redshift-dependent correction factor to the opacity, estimated from a commonly used cosmological EBL model. Considering this modified opacity, we identify the plausible VHE FSRQ candidates by linearly extrapolating the Fermi gamma-ray spectrum at 10 GeV to the VHE regime. Our study suggests that among 744 FSRQs reported in the Fermi Fourth Catalogue Data Release 2, 32 FSRQs will be detectable by the Cherenkov Telescope Array Observatory (CTAO). Because FSRQs are proven to be highly variable, we assume a scenario where the average Fermi gamma-ray flux increases by a factor of 10, and this predicts an additional 90 FSRQs that can be detected by the CTAO.
Photohadronic interpretations of the different incarnations of 1ES 2344+514
Authors: Sahu Sarira , Valadez Polanco Isabel Abigail , Rajpoot Subhash 
Published: August 2022

ABSTRACT
Since its discovery in 1995, the high-energy peaked blazar 1ES 2344+514 has undergone several episodes of GeV–TeV flaring and has been observed in the multiwavelength by several telescopes. The observed X-ray spectrum of 1996 and the flaring event of 2016 establish that 1ES 2344+514 has a temporary behaviour like that of an extremely high-energy peaked BL Lacertae object (EHBL). Such behaviour has also been observed in several nearby high-energy peaked blazars. We use the photohadronic model to account for the GeV–TeV flaring observed events of 1995 and 2007. Also, a recently proposed two-zone photohadronic model, which is successful in explaining the multi-TeV flaring events of many transient EHBL-like sources, is employed to explain the GeV–TeV flaring spectra of MJD 57611 and MJD 57612. We find that the zone-2 parameters of the two-zone photohadronic model play a central role in explaining these spectra. This is probably an indication of a new type of transient EHBL-like source. We find that our fits to the observed spectra are comparable or better than the other leptonic and hadronic models employed in the literature to address the same issue.
Regulation of nuclear DNA damage response by mitochondrial morphofunctional pathway
Authors: Oanh Nguyen Thi Kim , Lee Ho-Soo , Kim Yong-Hyun , Min Sunwoo , Park Yeon-Ji , Heo June , Park Yong-Yea , Lim Won-Chung , Cho Hyeseong 
Published: August 2022

Abstract
Cells are constantly challenged by genotoxic stresses that can lead to genome instability. The integrity of the nuclear genome is preserved by the DNA damage response (DDR) and repair. Additionally, these stresses can induce mitochondria to transiently hyperfuse; however, it remains unclear whether canonical DDR is linked to these mitochondrial morphological changes. Here, we report that the abolition of mitochondrial fusion causes a substantial defect in the ATM-mediated DDR signaling. This deficiency is overcome by the restoration of mitochondria fusion. In cells with fragmented mitochondria, genotoxic stress-induced activation of JNK and its translocation to DNA lesion are lost. Importantly, the mitochondrial fusion machinery of MFN1/MFN2 associates with Sab (SH3BP5) and JNK, and these interactions are indispensable for the Sab-mediated activation of JNK and the ATM-mediated DDR signaling. Accordingly, the formation of BRCA1 and 53BP1 foci, as well as homology and end-joining repair are impaired in cells with fragmented mitochondria. Together, these data show that mitochondrial fusion-dependent JNK signaling is essential for the DDR, providing vital insight into the integration of nuclear and cytoplasmic stress signals.
Structural basis of 3′-end poly(A) RNA recognition by LARP1
Authors: Kozlov Guennadi , Mattijssen Sandy , Jiang Jianning , Nyandwi Samuel , Sprules Tara , Iben James R , Coon Steven L , Gaidamakov Sergei , Noronha Anne M , Wilds Christopher J , Maraia Richard J , Gehring Kalle 
Published: August 2022

Abstract
La-related proteins (LARPs) comprise a family of RNA-binding proteins involved in a wide range of posttranscriptional regulatory activities. LARPs share a unique tandem of two RNA-binding domains, La motif (LaM) and RNA recognition motif (RRM), together referred to as a La-module, but vary in member-specific regions. Prior structural studies of La-modules reveal they are pliable platforms for RNA recognition in diverse contexts. Here, we characterize the La-module of LARP1, which plays an important role in regulating synthesis of ribosomal proteins in response to mTOR signaling and mRNA stabilization. LARP1 has been well characterized functionally but no structural information exists for its La-module. We show that unlike other LARPs, the La-module in LARP1 does not contain an RRM domain. The LaM alone is sufficient for binding poly(A) RNA with submicromolar affinity and specificity. Multiple high-resolution crystal structures of the LARP1 LaM domain in complex with poly(A) show that it is highly specific for the RNA 3′-end, and identify LaM residues Q333, Y336 and F348 as the most critical for binding. Use of a quantitative mRNA stabilization assay and poly(A) tail-sequencing demonstrate functional relevance of LARP1 RNA binding in cells and provide novel insight into its poly(A) 3′ protection activity.
Efficacy of Cabozantinib in Metastatic MiT Family Translocation Renal Cell Carcinomas
Authors: Thouvenin Jonathan , Alhalabi Omar , Carlo Maria , Carril-Ajuria Lucia , Hirsch Laure , Martinez-Chanza Nieves , Négrier Sylvie , Campedel Luca , Martini Dylan , Borchiellini Delphine , Chahoud Jad , Lodi Massimo , Barthélémy Philippe , Hasanov Elshad , Hahn Andrew W , Gil Thierry , Viswanathan Srinivas R , Bakouny Ziad , Msaouel Pavlos , Asim Bilen Mehmet , Choueiri Toni K , Albiges Laurence , Tannir Nizar M , Malouf Gabriel G 
Published: August 2022

Abstract

Background
MiT family translocation renal cell carcinoma (TRCC) is a rare and aggressive subgroup of renal cell carcinoma harboring high expression of c-MET. While TRCC response rates to VEGF receptor tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors are limited, efficacy of cabozantinib (a VEGFR, MET, and AXL inhibitor) in this subgroup is unclear.

Methods
We performed a multicenter, retrospective, international cohort study of patients with TRCC treated with cabozantinib. The main objectives were to estimate response rate according to RECIST 1.1 and to analyze progression-free survival (PFS) and overall survival (OS).

Results
Fifty-two patients with metastatic TRCC treated in the participating centers and evaluable for response were included. Median age at metastatic diagnosis was 40 years (IQR 28.5-53). Patients’ IMDC risk groups at diagnosis were favorable (9/52), intermediate (35/52), and poor (8/52). Eleven (21.2%) patients received cabozantinib as frontline therapy, 15 (28.8%) at second line, and 26 (50%) at third line and beyond. The proportion of patients who achieved an objective response was 17.3%, including 2 complete responses and 7 partial responses. For 26 (50%) patients, stable disease was the best response. With a median follow-up of 25.1 months (IQR 12.6-39), median PFS was 6.8 months (95%CI 4.6-16.3) and median OS was 18.3 months (95%CI 17.0-30.6). No difference of response was identified according to fusion transcript features.

Conclusion
This real-world study provides evidence of the activity of cabozantinib in TRCC, with more durable responses than those observed historically with other VEGFR-TKIs or ICIs.
Alginate hydrogel cross-linked by Ca2+ to promote spinal cord neural stem/progenitor cell differentiation and functional recovery after a spinal cord injuryhh
Authors: Zhou Jun , Wu Yaqi , Tang Zhijian , Zou Kaipeng , Chen Juan , Lei Zuowei , Wan Xueyan , Liu Yanchao , Zhang Huaqiu , Wang Yu , Blesch Armin , Lei Ting , Liu Shengwen 
Published: August 2022

Abstract
Alginate capillary hydrogels seeded with differentiated cells can fill the lesion cavity and promote axonal regeneration after grafting into the injured spinal cord. Neural stem/progenitor cells (NSPCs) can potentially repair the spinal cord; however, effects of alginate hydrogels (AHs) on NSPCs remain unknown. In this study, we fabricated AHs cross-linked by Ca2+ and seeded hydrogels with rat embryonic day 14 NSPCs. Immunocytochemistry and electron microscopy show that NSPCs survive, proliferate and differentiate into neurons in vitro within the capillaries. After transplantation into an acute T8 complete spinal cord transection site in adult rats, approximately one-third (38.3%) of grafted cells survive and differentiate into neurons (40.7%), astrocytes (26.6%) and oligodendrocytes (28.4%) at 8 weeks post-grafting. NSPCs promote the growth of host axons within the capillaries in a time-dependent manner. Host axons make synapse-like contacts with NSPC-derived neurons within the hydrogel channels, and graft-derived axons extend into the host white and gray matter making putative synapses. This is paralleled by improved electrophysiological conductivity across the lesion and partial hindlimb locomotor recovery.
‘The Last Shot’—the shared and distinct brain regions involved in processing unexpectedness of success and failure in the context of social cooperation
Authors: Li Peng , Wang Jing , Liu Yi 
Published: August 2022

AbstractIndividual success and failure in social cooperation matter not only to oneself but also to teammates. However, the common and distinct neural activities underlying salient success and failure in social cooperation are unclear. In this functional magnetic resonance imaging (fMRI) study, participants in the social group (Experiment one) cooperated with two human beings during a dice-gambling task, whereas those in the nonsocial group (Experiment two) cooperated with two computers. The social group reported more pride in success and more guilt in failure. The fMRI results in Experiment one demonstrate that left temporoparietal junction (LTPJ) activation increased exclusively with linearly changing unexpected success, whereas increasing anterior cingulate cortex (ACC) activation was only coupled with increasing unexpectedness of failure. Moreover, the dorsal medial prefrontal cortex (dMPFC) and left anterior insula were recruited in both success and failure feedback conditions. Dynamic causality model analysis suggested that the dMPFC first received information from the LTPJ and ACC separately and then returned information to these regions. The between-experiment comparison showed more dMPFC activity in social vs nonsocial contexts irrespective of success and failure feedback. Our findings shed light on the common and distinct neural substrates involved in processing success and failure feedback in social cooperation.
Measuring the response to visually presented faces in the human lateral prefrontal cortex
Authors: Nikel Lara , Sliwinska Magdalena W , Kucuk Emel , Ungerleider Leslie G , Pitcher David 
Published: August 2022

Abstract
Neuroimaging studies identify multiple face-selective areas in the human brain. In the current study, we compared the functional response of the face area in the lateral prefrontal cortex to that of other face-selective areas. In Experiment 1, participants (n = 32) were scanned viewing videos containing faces, bodies, scenes, objects, and scrambled objects. We identified a face-selective area in the right inferior frontal gyrus (rIFG). In Experiment 2, participants (n = 24) viewed the same videos or static images. Results showed that the rIFG, right posterior superior temporal sulcus (rpSTS), and right occipital face area (rOFA) exhibited a greater response to moving than static faces. In Experiment 3, participants (n = 18) viewed face videos in the contralateral and ipsilateral visual fields. Results showed that the rIFG and rpSTS showed no visual field bias, while the rOFA and right fusiform face area (rFFA) showed a contralateral bias. These experiments suggest two conclusions; firstly, in all three experiments, the face area in the IFG was not as reliably identified as face areas in the occipitotemporal cortex. Secondly, the similarity of the response profiles in the IFG and pSTS suggests the areas may perform similar cognitive functions, a conclusion consistent with prior neuroanatomical and functional connectivity evidence.
Physical Activity and Nutrition-Related Beliefs, Behaviors, and Challenges in Individuals Living With Cancer and Their Caregivers
Authors: Packel Lora , Dychtwald Dan , Pontiggia Laura , Deutsch Jonathan , Milliron Brandy-Joe 
Published: August 2022

Background and Purpose:
This study explored physical activity and nutrition beliefs, behaviors, and challenges; examined dyadic interactions; and explored lifestyle programming preferences to inform future interventions to improve the physical and mental health of patients with cancer and their caregivers.

Methods:
A convergent mixed-methods design with structured surveys and interviews. Descriptive statistics and quantitative comparisons were performed using SAS. Interviews were analyzed using inductive and deductive thematic analysis.

Setting:
Hope Lodge Cheltenham, Pennsylvania.

Participants:
Caregivers (n = 52) and patients (n = 50).

Intervention and Measurements:
The Godin Leisure Time Questionnaire, theory of planned behavior, and the National Cancer Institute's Food Attitudes and Behaviors Survey were embedded in structured surveys.

Results:
The sample was physically active with no significant changes postdiagnosis. Physical activity was lower in patients with higher fatigue, while it was higher in those with stronger intention and perceived behavioral control. Most participants believed that dietary intake was linked to health; however, there was confusion toward national recommendations. Higher levels of nutrition self-efficacy were associated with lower perceived barriers to nutrition in both groups. Participants wanted information tailored to cancer type provided in a variety of mediums by health care providers, researchers, and cancer centers.

Limitations:
Physically active sample of convenience, recall bias with questionnaires.

Conclusions:
Perceived behavioral control, intention to exercise, and education about using exercise for fatigue management and mental health should be emphasized. Nutrition interventions should focus on addressing barriers, clarifying guidelines, and operationalizing recommendations. Information should be specific to cancer type and include support for caregivers.
Rehabilitation Course and Management of Intravascular Lymphoma Presenting as Recurrent Strokes: A Case Report
Authors: Thomas Jade , Britton-Carpenter Amanda , Rucker Jason 
Published: August 2022

Background and Purpose:
Intravascular lymphoma (IVL) is characterized by the proliferation of lymphoma cells within small blood vessels. Diagnosis of IVL is difficult, and neurologic manifestations of the disease are common. Currently, there is little information related to the clinical course and rehabilitation of patients with IVL. This case report describes the presentation and treatment of an individual with IVL presenting as recurrent strokes.

Case Description:
A 53-year-old man was admitted for treatment of bilateral multifocal infarcts in cerebral watershed areas. Initial assessments indicated that he required minimal assistance for functional activities, and he was discharged home with outpatient services. He was readmitted 7 days later with worsening confusion, left hemiparesis, and deteriorating functional mobility. Rehabilitation team concerns related to the patient's progressive functional decline led to additional testing, resulting in a diagnosis of IVL.

Outcomes:
The patient initially required relatively little assistance with most functional activities, scoring 23 to 24/24 and 21/24 on the Activity Measure for Post-Acute Care (AM-PAC) Basic Mobility and Daily Activity Scales, respectively, 46/56 on the Berg Balance Scale (BBS), and 19/30 on the Montreal Cognitive Assessment (MoCA). He was subsequently readmitted and demonstrated a rapid functional decline, as evidenced by AM-PAC and BBS scores of 7/24 and 6/56, respectively.

Discussion:
This patient presented with neurological deficits and an initial diagnosis of bilateral multifocal infarcts. Documentation of his progressive functional decline and decreasing AM-PAC and BBS scores facilitated interdisciplinary communication and led to additional diagnostic testing, resulting in a final diagnosis of IVL and appropriate medical intervention.
Clinical Outcomes of Combined Anterior Cruciate Ligament Reconstruction and Lateral Extra-articular Tenodesis Procedures in Skeletally Immature Patients: A Systematic Review From the SANTI Study Group
Authors: Carrozzo Alessandro , Monaco Edoardo , Saithna Adnan , Annibaldi Alessandro , Guy Sylvain , Ferreira Alexandre , Vieira Thais Dutra , Ferretti Andrea , Sonnery-Cottet Bertrand 
Published: August 2022

Background:The treatment of anterior cruciate ligament (ACL) tears in the pediatric population has changed significantly in the past few decades. Pediatric patients who underwent ACL reconstruction (ACLR) have a high risk of rerupture of up to 32%. The addition of lateral extra-articular procedures [lateral extra-articular tenodesis (LET)], already shown to be effective in reducing the risk of rerupture in adults, may also be effective in pediatric patients. The purpose of this study was to systematically review the clinical outcomes of ACLR+LET tenodesis in pediatric patients.Methods:Data were collected from Pubmed, MEDLINE, Cochrane, and Scopus Databases according to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Studies reporting the clinical outcomes of ACLR+LET in the pediatric population using autograft, return to play, growth disturbances, failure rate, and surgical complications were included.Results:A total of 5 studies comprising 381 pediatric patients were included. Three main surgical techniques with common features were used. The mean age of all pediatric patients in the included studies was 11.73 years (range, 5.6 to 16) with a mean follow-up of 50.1 months. The overall graft failure rate of the included studies was 4.65%. The return to play was 95.11%. The mean Lysholm score was 94.51 and the mean Pediatric International Knee Documentation Committee (Pedi-IKDC) was 93.39. In all, 1.9% of the patients had a coronal plane deformity and 0.8% had a limb length discrepancy. 4.6% of the patients had a contralateral ACL tear.Conclusions:A combined ACLR+LET in pediatric patients showed a graft failure ranging from 0% to 13.6% at a mean follow-up of 50.1 months. This low graft failure rate is consistent with ACLR+LET in adults. Further investigations are needed to validate these findings and the potential role of LET in reducing graft rupture rates in this population.Level of Evidence:Level IV—systematic review of level IV studies.