bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Risk Factors Are Associated With Disability Prevalence – Results From 17 States in the 2017 Behavioral Risk Factor Surveillance System
Authors: Sharpe Jason A. , Miller Rachel , Cook Chad E. , Hastings Susan N. , Rethorn Timothy J. , Allen Kelli D. , Rethorn Zachary D. 
Published: October 2022

Purpose Determine the association between incremental increases in the number of social risk factors and the prevalence of any disability and disability type. Design The cross-sectional analysis was conducted using 2017 Behavioral Risk Factor Surveillance System data from states whose surveys included items about social risk factors. Setting Respondents from 17 US states. Subjects Respondents included 136 432 adults. Measures Dichotomized social risk factors included food, housing, and financial insecurity, unsafe neighborhood, and healthcare access hardship. Analysis Weighted χ2 and logistic regression analyses adjusted for demographic characteristics, measures of socioeconomic position, and comorbid health conditions were used to examine differences in the prevalence of disability by social risk factor and via a social risk index created by summing the social risk factors. Results Compared to those reporting 0 social risk factors, respondents reporting ≥4 had more than thrice the odds of reporting a cognition ((adjusted odds ratio [AOR]=3.37; 95%CI [2.75-4.13]), independent living (AOR=3.24 [2.52-4.15]), self-care (AOR=3.33 [2.55-4.34]), or any disability (AOR=3.90 [3.24-4.70]); more than twice the odds of reporting a vision (AOR=2.61 [1.93-3.52]) or mobility (AOR=2.72 [2.16-3.41]) disability; and more than 1.5 times the odds of reporting a hearing disability (AOR=1.59 [1.22-2.07]). Conclusions Incremental increases in the number of social risk factors were independently associated with higher odds of disability. Intervention efforts should address the social context of US adults with disabilities to improve health outcomes.
A 13-Year Time-Lagged Description of General Cognitive and Functional Abilities in Older Men: A Cross-Lagged Panel Model
Authors: Martin Peter , Poon Leonard W. , Lee Gina , Obhi Hardeep K. , Kallianpur Kalpana J. , Willcox Bradley , Masaki Kamal 
Published: October 2022

Objectives: The purpose of this study was to evaluate a cross-lagged panel model of general cognition and functional abilities over 13 years. The goal was to determine whether general cognitive abilities predict or precede functional decline versus functional abilities predicting cognitive decline. Methods: The sample included 3508 men (71–93 years of age at baseline) of the Kuakini Honolulu-Asia Aging Study who were tested repeatedly using a global cognitive test and an assessment of functional capacity. Education and age served as covariates. Cross-lagged models were tested, assessing stationarity of stability and cross-lags. Results: The overall model fit the data well. Cognitive scores had better stability than functional abilities and predicted functional abilities more strongly than functional abilities predicted cognitive scores over time. The strength of all cross-lags increased over time. Discussion: These longitudinal data show that cognitive scores predicted functional decline in a population-based study of older men.
Before reliable near infrared spectroscopic analysis - the critical sampling proviso. Part 2: Particular requirements for near infrared spectroscopy
Authors: Esbensen Kim H , Abu-Khalaf Nawaf 
Published: October 2022

Non-representative sampling of materials, lots and processes intended for NIR analysis is often fraught with hidden contributions to the full Measurement Uncertainty MUtotal = TSE + TAENIR. The Total Sampling Error (TSE) can dominate over the Total Analytical Error TAENIR by factors of 5 to 10 to even 25 times, depending on the degree of material heterogeneity and the specific sampling procedures employed to produce the minuscule aliquot, which is the only material actually analysed. Part 1 presented a brief of all sampling uncertainty elements in the “lot-to-aliquot” pathway, which must be identified and correctly managed (eliminated or reduced maximally), especially the sampling bias, as a prerequisite to achieve fully representative sampling. The key for this is the Theory of Sampling (TOS), which is presented in two parts in a novel compact fashion. Part 2 introduces (i) application of TOS to process sampling, specifically addressing and illustrating how this manifests itself in the realm of PAT, Process Analytical Technology, and (ii) an empirical safeguard facility, termed the Replication Experiment (RE), with which to estimate the effective sampling-plus-analysis uncertainty level (MUtotal) associated with NIR analysis. The RE is a defence against compromising the analytical responsibilities. Ignorance, either caused by lack of awareness or training, or by wilful neglect, of the demand for TSE minimisation, is a breach of due diligence concerning analysis QC/QA. Part 2 ends with a special focus on: “What does all this TOS mean specifically for NIR analysis?”. The answer to this question will perhaps surprise many. There is nothing special that need worrying NIR analysts relative to professionals from all other analytical modalities; all that is needed is embedded in the general TOS framework. Still, this review concludes by answering a set of typical concerns from NIR practitioners.
Perceived Causes of Cancer and Corresponding Behavioral Changes: A Qualitative Study on Breast Cancer Survivors in Taiwan
Authors: Niu Jasmine , Chen Duan-Rung , Lo Chiao , Cheng Shao-Yi , Huang Chiun-Sheng 
Published: October 2022

Objectives Breast cancer is the most common cancer among women in Taiwan, and treatment and coping with the disease become prominent features in a survivor’s life. Here, we examined Taiwanese survivors’ perceived causes of breast cancer, the influence of support networks on their perceptions, and the behavioral changes they made to prevent recurrences. Methods In this qualitative study, we used an explanatory approach involving semi-structured in-depth interviews based on grounded theory. We recruited (via physician referrals) 29 survivors aged ≥20 who had received their initial diagnosis at least 6 months earlier. Results Although the participants had made behavioral changes in many areas of their lives after diagnosis, most still believed that “stress and emotions” were the most crucial factor in causing cancer. They strongly emphasized reducing stress levels to prevent recurrences. However, when maintaining healthy behaviors became stressful, they chose to level off healthy lifestyles for the sake of their emotional well-being. They made career changes to improve their quality of life yet continued to experience a deep fear of recurrence. Adopting behavioral changes leading to healthy lifestyles and following regular follow-ups helped to reduce their anxiety concerning recurrence. Conclusion The participants’ behavioral changes were strongly associated with the perceived causes of cancer. Health-promotion programs aimed at breast cancer prevention should focus on participants’ subjective perception of the cause of cancer.
Squamous Cell Carcinoma of Skin Cancer Margin Classification From Digital Histopathology Images Using Deep Learning
Authors: Wako Beshatu Debela , Dese Kokeb , Ulfata Roba Elala , Nigatu Tilahun Alemayehu , Turunbedu Solomon Kebede , Kwa Timothy 
Published: October 2022

Objectives Now a days, squamous cell carcinoma (SCC) margin assessment is done by examining histopathology images and inspection of whole slide images (WSI) using a conventional microscope. This is time-consuming, tedious, and depends on experts’ experience which may lead to misdiagnosis and mistreatment plans. This study aims to develop a system for the automatic diagnosis of skin cancer margin for squamous cell carcinoma from histopathology microscopic images by applying deep learning techniques. Methods The system was trained, validated, and tested using histopathology images of SCC cancer locally acquired from Jimma Medical Center Pathology Department from seven different skin sites using an Olympus digital microscope. All images were preprocessed and trained with transfer learning pre-trained models by fine-tuning the hyper-parameter of the selected models. Results The overall best training accuracy of the models become 95.3%, 97.1%, 89.8%, and 89.9% on EffecientNetB0, MobileNetv2, ResNet50, VGG16 respectively. In addition to this, the best validation accuracy of the models was 94.7%, 91.8%, 87.8%, and 86.7% respectively. The best testing accuracy of the models at the same epoch was 95.2%, 91.5%, 87%, and 85.5% respectively. From these models, EfficientNetB0 showed the best average training and testing accuracy than the other models. Conclusions The system assists the pathologist during the margin assessment of SCC by decreasing the diagnosis time from an average of 25 minutes to less than a minute.
The Modified Five-Item Frailty Index to Predict Hand and Wrist Surgical Repair Postoperative Outcomes: An ACS-NSQIP Analysis of 11 369 Patients
Authors: Ibelli Taylor J. , Alerte Eric , Akhavan Arya , Liu Helen , Kuruvilla Annet , Katz Abigail , Etigunta Suhas , Taub Peter J. 
Published: October 2022

Background: Hand and wrist injuries can cause painful, everyday obstacles for patients. Carefully indexing preoperative patient health conditions may better inform surgical care, leading to improved postoperative outcomes. The purpose of the present study is to evaluate if the Modified Five-Item Frailty Index (mFI-5) can accurately predict postoperative complications for hand and wrist surgical repair. Methods: A retrospective review of the American College of Surgeons’ National Surgical Quality Improvement Program database was conducted to investigate patients who underwent hand and wrist surgical repair from January 2013 to December 2019. Patient demographics, comorbidities, surgical logistics, and 30-day readmission due to postoperative complications were extracted. Surgical risk proxies including the mFI-5, age, body mass index (BMI), smoking status within 1 year, the Modified Charlson Comorbidity Index (mCCI), comorbidities, and American Society of Anaesthesiologists Physical Status Classification (ASA class) were calculated. Results: A total of 11 369 patients were included. Thirty-day readmission for total postoperative complications (n = 258) was significantly associated with all surgical risk proxies. However, age, mFI-5 > 2, mCCI > 2, comorbidities > 1, and ASA class 2/3 had the highest statistical significance ( P = <.001). Thirty-day readmission rates for surgical site infections (n = 118) had the highest statistical significance with age, BMI, mFI-5 > 2, and ASA class 2/3 ( P = <.001). A Clavien-Dindo score > 1 (n = 224) had the highest statistical significance with age, mCCI > 2, comorbidity of 1, and an ASA class 3 ( P = <.001). Conclusions: The mFI-5 may have value in predicting 30-day readmission due to postoperative complications after surgical repair of hand and wrist injuries.
A qualitative study of factors influencing COVID-19 vaccine hesitancy among South Asians in London
Authors: Chandok Raj S. , Madar Poonam , Majeed Azeem 
Published: October 2022

Objectives This qualitative study sought to elicit the views and experiences of patients and health-care professionals to identify the factors associated with COVID-19 vaccine hesitancy among South Asians in London. Design In-depth semi-structured telephone and virtual interviews. Setting UK. Participants Convenience and purposive sample of 12 individuals including patients, clinicians, and a medical receptionist. Main Outcome Measures Our dataset identifies and explains the reasons for distinguishing between those individuals who are COVID-19 vaccine-hesitant, and those who are COVID-19 vaccine-anxious. Results COVID-19 vaccine hesitancy and the decision on whether to - or not to – vaccinate against COVID-19 involves ongoing and unresolved inner conflict about COVID-19 vaccines. Our findings therefore suggest that some individuals may be existing in a state of inbetweeness; where they are neither pro nor anti vaccination, while simultaneously questioning the many ‘truths’ surrounding COVID-19 and not just one truth such as the safety of COVID-19 vaccines. We argue that this in-between state is intensified by technology and social media; culminating in the Rashomon Effect, whereby a combination of truths, fractured truths, subjective realities, and unreliable or contradictory sources impact on our perceptions of COVID-19. Conclusions Given the complexities arising from the multiple factors influencing vaccine hesitancy and scepticism, ‘quick fixes’ and ‘one size fits all’ solutions to address COVID-19 vaccine hesitancy will be ineffective. Therefore, promoting trust and prioritising good after-care as well as on-going care as a response to the effects of the pandemic is vital.
Quantitative bone SPECT/CT for evaluating treatment response in patient with sternoclavicular arthritis
Authors: Komoto Hisashi , Kitajima Kazuhiro , Azuma Naoto , Tamura Masao , Yokoyama Hiroyuki , Tsuchitani Tatsuya , Yamakado Koichiro 
Published: October 2022

We report here a case of sternoclavicular arthritis due to SAPHO syndrome in a 60-year-old female in which quantitative values determined using bone SPECT/CT were useful to evaluate response. After celecoxib and alendronate sodium hydrate therapy, the chief complaints were well relieved and post-treatment Tc-99m HMDP bone SPECT/CT examination showed decreased uptake. The maximum standardized uptake value (SUV), peak SUV, mean SUV, metabolic bone volume, and total bone uptake of the untreated lesion were 18, 16, 10, 17 mL, and 180, respectively, which were decreased to 8, 7, 5, 15 mL, and 75, respectively, after the treatment. In comparison with pre-treatment situation, those parameters were decreased by −56%, −56%, −50%, −12%, and −58%, respectively, following celecoxib and alendronate sodium hydrate therapy, likely reflecting treatment response. Quantitative bone SPECT/CT may be useful to evaluate joint inflammatory activity and treatment response in a patient with osteoartritis.
Revision Anterior Cruciate Ligament Reconstruction Using Bone Dowels
Authors: Ignozzi Anthony J. , MacLean Ian , Miller Mark 
Published: October 2022

Background: Revision anterior cruciate ligament (ACL) reconstruction is technically challenging and may require the use of bone dowels in either 1 or 2 stages. Indications: The indications for bone dowels include tibial or femoral tunnel malposition or widening of the tunnels. In the patient case, the tibial tunnel aperture was positioned far medial to the native ACL insertion with a horizontal tunnel trajectory and the femoral tunnel was vertical. In addition, there was tunnel widening to 12 mm of both tibial and femoral tunnels. Technique Description: A bone-patellar tendon-bone autograft was harvested and diagnostic arthroscopy was performed. The previous tibial tunnel was sequentially reamed from 8 to 12 mm to adequately overdrill the previous widened tunnel. Next, the femoral tunnel was reamed to 12 mm in similar fashion. Using a tamp and guide pin, a 12 × 30-mm allograft bone dowel was then malleted into the femoral tunnel until it was flush with the medial aspect of the lateral femoral condyle. Another 12 × 30-mm bone dowel was then advanced into the tibial tunnel until it was just below the native articular margin. With the bone dowels securely in place, the ACL reconstruction using the harvested bone-patellar tendon-bone autograft was performed. Results: Werner et al reported a study of 12 patients who had excellent incorporation of femoral tunnel allograft bone dowels and comparable objective and subjective scoring to 2-stage techniques. Dragoo et al reported a study of 18 patients with tibial tunnel allograft bone dowels that demonstrated significant increases in patient-reported outcome measures and a significant decrease in tunnel widening. Discussion/Conclusion: Revision ACL reconstruction may require bone dowels if there are malpositioned tunnels or if there is tunnel widening. Overall, the literature demonstrates that 1-stage revision outcomes have been comparable to reported 2-stage revision outcomes, both of which are satisfactory.
Comprehensive collection of genes and comparative analysis of full-length transcriptome sequences from Japanese larch (Larix kaempferi) and Kuril larch (Larix gmelinii var. japonica)
Authors: Mishima Kentaro , Hirakawa Hideki , Iki Taiichi , Fukuda Yoko , Hirao Tomonori , Tamura Akira , Takahashi Makoto 
Published: October 2022

Abstract
Background
Japanese larch (Larix kaempferi) is an economically important deciduous conifer species that grows in cool-temperate forests and is endemic to Japan. Kuril larch (L. gmelinii var. japonica) is a variety of Dahurian larch that is naturally distributed in the Kuril Islands and Sakhalin. The hybrid larch (L. gmelinii var. japonica × L. kaempferi) exhibits heterosis, which manifests as rapid juvenile growth and high resistance to vole grazing. Since these superior characteristics have been valued by forestry managers, the hybrid larch is one of the most important plantation species in Hokkaido. To accelerate molecular breeding in these species, we collected and compared full-length cDNA isoforms (Iso-Seq) and RNA-Seq short-read, and merged them to construct candidate gene as reference for both Larix species. To validate the results, candidate protein-coding genes (ORFs) related to some flowering signal-related genes ​were screened from the reference sequences, and the phylogenetic relationship with closely related species was elucidated.

Results
Using the isoform sequencing of PacBio RS ll and the de novo assembly of RNA-Seq short-read sequences, we identified 50,690 and 38,684 ORFs in Japanese larch and Kuril larch, respectively. BUSCO completeness values were 90.5% and 92.1% in the Japanese and Kuril larches, respectively. After comparing the collected ORFs from the two larch species, a total of 19,813 clusters, comprising 22,571 Japanese larch ORFs and 22,667 Kuril larch ORFs, were contained in the intersection of the Venn diagram. In addition, we screened several ORFs related to flowering signals (SUPPRESSER OF OVEREXPRESSION OF CO1: SOC1, LEAFY: LFY, FLOWERING Locus T: FT, CONSTANCE: CO) from both reference sequences, and very similar found in other species.

Conclusions
The collected ORFs will be useful as reference sequences for molecular breeding of Japanese and Kuril larches, and also for clarifying the evolution of the conifer genome and investigating functional genomics.
Management of oesophageal foreign bodies in children: a 10-year retrospective analysis from a tertiary care center
Authors: Xu Guo , Chen Yong-chao , Chen Jing , Jia De-sheng , Wu Ze-bin , Li Lan 
Published: October 2022

Abstract
Objective
Oesophageal foreign bodies (EFBs) are a common emergency issue in paediatrics, and few studies have revealed its clinical features and treatment methods. We conducted this retrospective study to provide our 10-year clinical evidence for the diagnosis and treatment of EFB and reduce the incidence of complications.

Methods
We retrospectively reviewed all paediatric cases diagnosed with EFB from January 2012 to December 2021 at Shenzhen Children’s Hospital. The age and sex of the patients, types of foreign bodies (FBs), preoperative examination, location and duration of FB impaction, clinical symptoms, surgical methods, therapeutic effects and complications were analysed.

Results
Among the 1355 cases, 759 were boys and 596 were girls, with a median age of 2.9 years (4 months to 16 years). The shortest FB lodged time was 1 hour, while the longest time was 3 months. The types of foreign bodies included coins and blunt objects (812,59.9%), bones and sharp objects (278,20.5%), button batteries (86,6.3%), food impactions (84,6.2%), toys (51,3.8%) and plastic objects (44,3.2%). A total of 720 of 812 cases impacted by coins and blunt subjects were successfully treated with a Foley catheter without any complications. A total of 558 patients underwent rigid oesophageal endoscopy under general anaesthesia, and foreign bodies were successfully removed in 525 cases. No FB was found in 33 cases, and FBs pushed into the lower digestive tract during operation in 5 cases. Oesophageal injury was found in 130 cases (23.3%). Our study showed that the age of the patient, time of foreign body incarceration, type of foreign body, location of the lodged foreign body, and fever or cough were risk factors leading to oesophageal foreign body complications, and the differences were statistically significant (P < 0.05).

Conclusion
Children with EFB have a risk of complications, especially if the FB is a button battery. The appropriate surgical method should be selected through the analysis of the clinical characteristics of the foreign body in the oesophagus and the risk factors for complications to reduce the incidence of complications. Health education and effective care are the keys to the prevention of EFB.
Pathogen load and species monitored by droplet digital PCR in patients with bloodstream infections: A prospective case series study
Authors: Shao Ziqiang , Zhu Jingwen , Wei Yanyan , Jin Jun , Zheng Yang , Liu Jingquan , Zhang Run , Sun Renhua , Hu Bangchuan 
Published: October 2022

Abstract
Background and objectives:
Bloodstream infection (BSI) is a life-threatening condition in critically ill patients, but pathogen quantification techniques during treatment are laborious. This study aimed to explore the impact of monitoring pathogen DNA load changes and polymicrobial infection in blood by droplet digital polymerase chain reaction (ddPCR) on the prognosis of patients with BSIs.

Methods
This prospective case series study was conducted in the general intensive care unit of the Zhejiang Provincial People’s Hospital and included patients with BSIs from May 2020 to January 2021. Pathogens DNA load and presence of polymicrobial BSIs were dynamically monitored by ddPCR.

Results
Sixteen patients with BSIs proven by blood culture were recruited (87.5% men; mean age, 69.3 ± 13.7 years). All pathogens identified by blood culture were Gram-negative bacteria, among which seven were multidrug-resistant strains. The 28-day mortality rate was 62.5%. Compared to the 28-day survivors, the non-survivors were older (P = 0.04), had higher pathogen DNA load on the second (day 3–4) and third (day 6–7) ddPCR assay (P < 0.01 in both cases). In addition, the changes of pathogen DNA load in the 28-day survivors had a downward trend in the first three ddPCR assay, whereas stable load or an upward trend was observed in the 28-day non-survivors. Moreover, the number of pathogen species in patients with BSIs in the 28-day survivors decreased during the period of effective antibiotic treatment.

Conclusion
The changes of pathogen DNA load and species monitored in blood by ddPCR may be used to determine antibiotic efficacy and make a more accurate prognostic assessment in patients with BSIs.