bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Sustainable Synthesis of functionalized Carbon Quantum Dots from Hair for the applications of Cytotoxicity study and In vitro bioimaging
Authors: Kamble Pranoti Anil , Gambhir Rutuja Prashant , Vibhute Anuja Arvind , Parkhe Vishakha Suryakant , Tiwari Arpita Pandey 
Published: September 2022

Abstract

A simple and low-cost approach for the sustainable synthesis of carbon quantum dots (CQDs) were developed by using hair as carbon source without using any chemicals. Interestingly, not only the carbon source of CQDs, the whole synthesis procedure is environmentally friendly, and the synthesized sustainable functionalized CQDs have shown many beneficial properties such as high fluorescence intensity, excellent photostability, and good water solubility. Sustainable functionalized CQDs which were firstly synthesized from hair by a microwave method. The functionalization agent used in sustainable functionalized CQDs synthesis was poly l-lysine (PLL) and characterized using UV-vis absorption spectroscopy, Fluorescence spectroscopy, Fourier transform infrared spectroscopy (FTIR) spectroscopy, Transmission electron microscopy (TEM)technique. The synthesized sustainable functionalized CQDs emit blue fluorescence under UV light (at 365nm). A microwave oven (350 watts) was used to prepare sustainable CQDs within 5–7 second. As a bioimaging probe, the potential application of the prepared sustainable functionalized CQD was assessed by treating MCF7 Cells and L929 cell. The biological activity of as-prepared sustainable functionalized CQDs has been tested with respect to its inherent cytotoxicity, where the sustainable functionalized CQDs exhibited significant anti-cancer property against breast cancer cell lines in vitro application.
Spirometric profile among detergents factory workers in Palestine: A Cross-Sectional Study
Authors: Rahhal Belal , Nazzal Zaher , Jamal Abrar , quqa Ola , makharze Tasneem , Aqel Noora 
Published: September 2022

Abstract
The exposure to chemicals in cleaning factories and companies, as some studies have shown negatively affect the health of their respiratory system. The aim of the study was to determine the effect of chemical substances on lung function of the factories' workers. Spirometry parameters were compared between chemical factories workers and non-workers.
Methods: A comparative cross-sectional study of employees of chemical cleaning materials companies and factories, including male's category. An interviewer-administered questionnaire was used to record workers' characteristics, and the data entered to the spirometry device. The spirometry test was performed to assess workers' lung functions; we recorded the forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, peak expiratory flow (PEF), forced expiratory flow between 25 and 75% of FVC (FEF25-75%), and lung age.
Results: A total of 94 apparently participants (28 workers and 66 nonworkers) were included in the study. Chemical factories workers showed significant decreasing in the values of FEV1, FEV1/FVC ratio, PEF, FEF25-75%, and lung age compared to non-workers group (P < 0.05 to P <0.001).
Conclusion: Exposure of workers to chemicals is associated with reduced spirometry parameters of the lung function in healthy adults with relatively limited working years.
Assessment of microbial indicators of water resources in the KooheHava and TangeKhoor Free Area in Iran
Authors: Alizadeh Abolhasan , Nowzari Haniyeh 
Published: September 2022

Abstract
In the wildlife management, maintaining water quality and quantity, especially in areas that are faced with relative constraints of water resouces, are considered as one of the planning pillars. Natural springs and artificial troughs in the Kooh Hava and Tange Khoor Free Area are the only sources of water suppliers for wildlife of the area. The aim of this study was to investigate the microbial indices of water resources used by wildlife in this areas and to compare them with the Iranian national standard limit. In this study, 12 water sources including ten springs and two troughs were selected and sampling was carried out in two seasons of summer and autumn of 2020 and three samples from each water resources and a total of 72 samples were collected throughout the study period. Finally, the samples were transferred to lab in the glass sterile containers, and the parameters of total coliform, fecal coliform, temperature, turbidity and pH were extracted. The results showed that the means of total coliform were higher than the standard limit in the all water resources with the exception of no. 4 and 12 springs (Kaftari and Mokhi springs) and the means of fecal coliform were higher than the standard limit in the all water resource with the exception of no. 2, 4, 8, 10, 11 and 12 water resources (Palangi, Kaftari, Tehran and Mokhi springs and Harar and Biro troughts) both during summer and autumn. In summer, with increasing evaporation, the amount of pollution load of water resources was higher, however in autumn, the number of polluted water resources was higher which was due to the transmission of microbial contaminations caused by human and animal feces via rain. The results of correlation showed decrease or increase of turbidity, temperature or pH did not affect the amount of coliforms because despite the strong correlation between total coliform and fecal coliform, no correlation was found between them and physicochemical factors of water. Therefore, considering the temporal and spatial variability of fecal coliforms and their effect on disease, death and reduction of wildlife populations, optimizing and disinfection of water resources with chlorine and dredging them are recommended.
Determination of subpicogram levels of airborne polycyclic aromatic hydrocarbons for personal exposure monitoring assessment
Authors: Drooge Barend L. , Prats Raimon M. , Flo Clara Jaén , Grimalt Joan O. 
Published: September 2022

Abstract
A method based on the use of GC coupled to Q-exactive Orbitrap Mass Spectrometry (GC-Orbitrap-MS) has been developed for the analysis of polycyclic aromatic hydrocarbons (PAHs) at sub-picogram levels. Outdoor ambient air particulate matter (PM2.5) and standard reference materials (SRM2260a) were analyzed in full scan mode showing low instrumental uncertainties (1% - 22%) and high linearity over a wide concentration range (0.5 pg and 500 pg/µL). Good reproducibility was obtained compared to the use of conventional single quadrupole GC-MS of PM samples. The quantification limit of the GC-Orbitrap-MS method for full scan analysis of PAHs in outdoor ambient air PM samples was 0.5 pg/µL. This low limit allowed the analysis of PAHs in samples collected with low volumes (<0.5 m3), such as punch samples from whole filters or filter strips from personal exposure monitoring equipment. PAHs were successfully analyzed in filter strips from real-time Aethalometer AE51 equivalent black carbon (eBC) analyzers used in urban and rural sites, and in personal exposure monitors of firefighters during prescribed burns. The correlations between PAHs and eBC in these analyses were very strong (r2 ≥ 0.93). However, the equations obtained reflected the dominance of different emission sources, such as traffic in urban areas, wood burning for domestic heating, or wildfires. The method reported here affords the analyses of PAHs in high precision studies of atmospheric PM samples, e.g., high frequency sampling of low volumes, affording personal exposure monitoring assessments.
Lymph node metastasis in muscle-invasive bladder cancer risk factors and the construction of a predictive model
Authors: xiong Dongwen , Wang Qinzhang 
Published: September 2022

Abstract
Background
Muscle invasive bladder cancer is a fatal malignancy, and the main reason for the current controversy over its surgical options is the inability to accurately know whether lymph node metastases are present, so it is crucial to clarify the preoperative lymph node status. The aim of this study was to construct a validated lymph node metastasis prediction model from patients' preoperative clinical data
Material and Methods
Clinicopathological data of 3789 patients diagnosed with muscle-invasive bladder cancer in the SEER database from 2010 to 2015 and 367 patients with GDC-BLCA in the TCGA database were collected and divided into training cohorts and validation cohorts. Independent risk factors for LNM in muscle-invasive bladder cancer were screened using univariate and multivariate logistic regression analyses and a nomogram model was produced. ROC curves, and calibration curves were used to assess the predictive accuracy and discriminatory power of the nomogram model, decision curve analysis to assess the clinical application value of the model, and internal validation of the model using 1000 bootstrap replicates.
Results
A total of 3789 patients with muscle-invasive bladder cancer were included in this study, of whom 807 had LNM. Multifactorial logistic analysis showed that race, age, T-stage and the presence of primary tumor were independent risk factors for predicting LNM in muscle-invasive bladder .The nomogram prediction model was constructed based on the above four indicators, and its consistency index was 0.725 (95% CI: 0.705–0.745) and 0.710 (95% CI: 0.657–0.762) for the training and validation cohorts, respectively. The calibration curves showed a good agreement between the predicted and actual probabilities. The clinical decision curve analysis showed that the column line graph had good clinical application value.
Conclusion
The nomogram of the risk of LNM in muscle-invasive bladder cancer constructed based on the SEER database has good predictive ability and helps clinicians make appropriate clinical decisions for patients with muscle-invasive bladder cancer.
Numerical and experimental determination of the interference coefficient of two side-by-side cylinders with a smooth and rough surface
Authors: Padewska-Jurczak Agnieszka , Szczepaniak Piotr , Walentyński Ryszard , Wiśniowski Maciej , Cornik Dawid 
Published: September 2022

AbstractThe aim of the work is to perform numerical and experimental analyses of the wind flow around two structures with a circular cross-section placed side by side. These structures can have a smooth and a rough surface. In that case, the values of interference coefficient presented in Eurocode differ from those obtained from the author's numerical analyses, concerning very large Reynolds numbers Re. The aerodynamic drag force of the cylinder systems is determined on the basis of numerical Finite Volume Method analyses using the Computational Fluid Dynamics (CFD) module. Velocity and pressure fields are also presented. In order to verify the results, experimental tests were carried out in a wind tunnel. The results obtained at all stages (numerical models with a large number of Re; experimental studies of models with a lower Re number; numerical models with a lower Re number) were compared with each other. Each of the flow ranges (turbulent, transitional, laminar) is characterized by a different behavior and therefore, the aim of the work is also the correct creation of numerical models. Thus it is necessary to adjust the parameters of the numerical model. These analyses are used for testing the possibility of estimating wind load acting on a fragment of a structure of more complex, curved shape (e.g., water slide) using simplified models (e.g., helices, toruses, and cylinders). Eurocode EN 1991-1-4 does not cover complex structures based on circular cylinders.
Study of physicochemical, flammability, and acoustic properties of Hookeri raphia natural from Cameroon
Authors: Mveh Jean de Dieu Briand Minsongui , Ligabue Rosane Angélica , Einloft Sandra Mara Oliveira , De Lima Jeane Estela Ayres 
Published: September 2022

Abstract

The development of new materials is ultimately associated with requirements such as strength, lightness, low production cost, and raw materials from renewable sources, seeking to meet the needs, research, and development of new technologies, which value the qualification of materials from vegetable sources as natural fibers. In this context, this study aimed to characterize the main physicochemical properties of the natural raffia fiber and its flammability and thermo-acoustic characteristics. These characterizations were performed using a combination of several techniques such as chemical composition analysis, density, moisture adsorption, SEM-EDS, FTIR, and TGA/DTG. The results showed that the morphology of the raffia fiber presents a similar shape to the beehive. The Elemental analysis of the natural fiber of raffia shows that carbon and oxygen contents are predominant representing a proportion of more than 90%. The results suggest that the fiber is composed of lignin, hemicellulose, cellulose, tannin, and extractives, with cellulose in a proportion of 80%. TGA presents a profile similar to that of large parts of untreated vegetable fibers. The acoustic test showed very good sound absorption coefficient (α) values at high frequencies, while the flammability test showed that natural raffia fiber is a good flame retardant.
Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea
Authors: Hu Xiaojie , Zhang Liyan , Xu Changling , Sun Qiuhan , Li Nianci , Chen Xin , Jiang lulu , Shi Yi , Chai Renjie , Qi Jieyu 
Published: September 2022

Abstract
Sensorineural hearing loss a result from hair cell damage, which is irreversible in mammals owing to the lack of hair cell regeneration, but recent researches have shown that Lgr5+ supporting cells are progenitors capable of regenerating hair cells. RPS14 (ribosomal protein S14) is a 40S ribosomal subunit component and is associated with erythrocyte differentiation, and in this study, we used a novel AAV-ie system to upregulate Rps14 expression in cultured hair cell progenitors and observed their ability to proliferate and differentiate into hair cells. Similarly, Rps14 overexpression in vivo could promote supporting cells proliferation by activating the Wnt signaling pathway. In addition, over-expressing Rps14 induced hair cells regeneration in the organ of Corti, and lineage tracing revealed showed that the neo- hair cells had transformed from Lgr5+ hair cell progenitors. Combined with RNA sequence analysis, signals regulated by Rps14 include cell cycle-related factors during supporting cell proliferation and Notch/TGF-β signaling during hair cell reprogramming. In conclusion, our analysis reveals the potential role of Rps14 in driving hair cell regeneration in mammalian.
Hypocalcemia is associated with adverse outcomes in patients hospitalized with COVID-19
Authors: Minasi Alessandro , Andreadi Aikaterini , Maiorino Alessio , Giudice Luca , De Taddeo Sofia , D’Ippolito Ilenia , de Guido Ilaria , Laitano Rossella , Romano Maria , Ruotolo Valeria , Magrini Andrea , Daniele Nicola Di , Rogliani Paola , Bellia Alfonso , Lauro Davide 
Published: September 2022

Abstract

Purpose
Calcium ions are involved in the regulation of several cellular processes and may also influence viral replication. Hypocalcemia has been frequently reported during infectious diseases and in critically ill patients, significantly related with the pro-inflammatory state and mortality. The aim of this study is to investigate the prevalence of hypocalcemia at admission in patients hospitalized for COVID-19 (Coronavirus disease 2019) and to evaluate association of hypocalcemia with in-hospital COVID-19 outcomes.
Methods
Retrospective analysis on 118 consecutive patients, hospitalized for COVID-19 between March and May 2020. Clinical characteristics, inflammation markers, biochemical routine and mineral metabolism parameters at admission were collected. Hypocalcemia was defined as total serum calcium < 2.2 mmol/L. Population was stratified by tertiles of total serum calcium. Primary outcome was the composite of in-hospital death or admission to intensive care unit (ICU). Secondary outcomes included in-hospital death, admission to ICU and need for non-invasive ventilation as separate events. Associations were tested by logistic regression and Cox-regression analysis with survival curves.
Results
Overall prevalence of hypocalcemia was 76.6%, with just 6.7% of patients reporting levels of 25-(OH)-vitamin D > 30 ng/ml. Total serum calcium was inversely related with selected inflammatory biomarkers (p < 0.05) and poorer outcome of COVID-19 during hospitalization. Lower tertile of total calcium (≤ 2.02 mmol/L) had increased risk of in-hospital mortality (HR 2.77; 1.28–6.03, p = 0.01) compared with other groups.
Conclusion
Total serum calcium detected on admission is inversely related with proinflammatory biomarkers of severe COVID-19 and may be useful to better define risk stratification for adverse in-hospital outcome.
Positive periodic solutions to a generalized Ermakov-Pinney equation with indefinite weights
Authors: Cheng Zhibo , Song Juan 
Published: September 2022

Abstract
We consider a generalized Ermakov-Pinney equation with indefinite weights
x" + α(t)x = h(t)/xρ,
where ρ is a real constant and ρ > 0, α, h ∈ L1(R/TZ). Using the positivity of Green'sfunction andKrasnoselskiĭ's-Guo fixed point theorem, we give sufficient conditionsguaranteeing the existence of at least one positive periodicsolution for Ermakov-Pinney equation with indefinite weights. Theresults are applicable to weak as well as strong singularities.
The Ratio of Monocytes to Lymphocytes Multiplying Platelet Predicts Incidence of Pulmonary Infection-Related Acute Kidney Injury
Authors: Shen Bo , Zou Zhouping , Li Yang , Jia Ping , Xie Yeqing , Gong Shaomin , Teng Jie , Xu Jiarui , Yang Cheng , Ding Xiaoqiang 
Published: September 2022

Abstract
Background: Inflammation is a crucial factor in the pathogenesis and development of acute kidney injury (AKI). Macrophages, as an important innate immune cell, regulate immune response and play a pathophysiological role in AKI. This study aimed to evaluate the predictive capacity of peripheral blood monocytes for the incidence of pulmonary infection-related AKI.
Methods: We recruited 1,038 hospitalized patients with pulmonary infections from January 1 to December 31, 2019 in Zhongshan Hospital, Fudan University. Patients were divided into derivation and validation cohorts. Data on demographic characteristics, disease history, and biochemical indexes were retrieved from the electronic medical system. The composite inflammatory indexes were calculated as monocyte / (lymphocyte × platelet ratio) (MLPR). We applied dose-response relationship analyses to delineate the non-linear odds ratio (OR) in different MLPR levels and integrated it into logistic model to predict the risk of AKI.
Results: The incidence of hospital-acquired AKI was 18.8% in the derivation cohort. Compared to non-AKI, the MLPR levels were significantly higher in AKI patients. Dose-response curve revealed that the increase of AKI risk was faster in the first half of MLPR and then tended to flatten. After classifying the MLPR levels into six groups, the AKI incidence increased from 4.5% to 55.3% with a peaking OR of 24.38. The AUC values of AKI model only included MLPR were 0.740, and after gradually integrating other covariates, the area under the receiver operating characteristic (AUC) value reached 0.867, which was significantly higher than the AUC of full models without MLPR (0.827). Moreover, the better prediction ability of AKI was observed in the external validation, with an AUC of 0.899.
Conclusion: MLPR has good predictive efficiency in AKI, which can be used as a simple and easy clinical composite index to effectively predict early pulmonary infection-related AKI.
Hyperphosphatemia in Patients with Chronic Kidney Disease (CKD)
Authors: kim jihyun 
Published: September 2022

Abstract
Background: Hemodialysis patients with chronic kidney disease have low glomerular filtration rates, and hyperphosphatemia develops due to difficulty reducing the phosphate load. Hyperphosphatemia can cause renal osteodystrophy, cardiovascular calcification, and secondary hyperparathyroidism.
Methods: This is a descriptive research study designed to identify factors influencing the development of hyperphosphatemia in patients diagnosed with chronic kidney disease. A convenience sample of 150 patients receiving hemodialysis was selected. Data were collected directly by the researchers from January to March 2022.
Results : The regression model was found to be significant (χ2 = 137.24, p<.001). Regression analysis among the general characteristics found that BMI was a predictive factor. The risk of hyperphosphatemia was 11.53 times (95% CI, 1.25-108.52) higher for a BMI ≥25 kg/m2 than for a BMI <18.5 kg/m2and 1.03 times (95% CI, 0.97-1.09) higher for a high BUN.
Conclusions: Results showed that high BMI and BUN levels were associated with a high risk of developing hyperphosphatemia. Therefore, to prevent and manage the development of hyperphosphatemia, it is necessary to regular monitoring for dietary and nutritional status as the disease progresses, individual dietary education should be provided based on each patient's clinical symptoms, biochemical parameters, and nutritional status. And it is necessary to improve self-care compliance by providing accurate information about the disease and providing systematic education.
Electrical resistivity tomography to detect ground loosened zone near excavation region in an urban site of ground subsidence, South Korea
Authors: Song Seo Young , Kim Bitnarae , Cho Ahyun , Jeong Juyeon , Lee Dongkweon , Nam Myung Jin 
Published: September 2022

Abstract
Ground subsidence in urban environment due to excessive development and deteriorated underground urban facilities is serious social problem. Geophysical surveys were applied to estimate distribution and scale of cavities and subsidence. In this study, electrical resistivity tomography (ERT) was performed near the subsidence occurred on road in urban area. The subsidence arose due to leak of groundwater and soil into neighboring excavation region. The survey line was located between the major subsidence area and excavation region. Since ERT data are affected by rapid topographic change or surrounding structure, influences of the excavation to data were analyzed through field-scale numerical modeling. The effect of excavation should be considered to interpret ERT data, as it can be estimated wrong anomaly. In 2D interpretation, a method of performing inversion after correcting the resistivity data including the effect of excavation was proposed. This method was proved first using the field-scale numerical model including excavation region and subsurface anomaly assuming loosened zone and then applied to field data. In addition, the ERT data were interpreted by using existing a 3D in-house algorithm, which can deal with excavation region. Both of inversion results demonstrated that conductive anomalies of loosen zone appeared stronger in more specific area compared to before considering the excavation effect.