bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epithelial-mesenchymal transition-related genes in coronary artery disease
Authors: Xu Xiang , Zou Renchao , Liu Xiaoyong , Liu Jia , Su Qianqian 
Published: April 2022

Abstract
Epithelial-mesenchymal transition (EMT) is critical in the development of coronary artery disease (CAD). However, landscapes of EMT-related genes have not been fully established in CAD. We identified the differentially expressed mRNAs and lncRNAs (DElncRNAs) from the Gene Expression Omnibus database. Pearson’s correlation analysis, the least absolute shrinkage and selection operator regression, and support vector machine reverse feature elimination algorithms were used to screen EMT-related lncRNAs. The cis–trans regulatory networks were constructed based on EMT-related lncRNAs. Quantitative real-time polymerase chain reaction was performed to validate the expression of EMT-related genes in a cohort of six patients with CAD and six healthy controls. We further estimated the infiltration of the immune cells in CAD patients with five algorithms, and the correlation between EMT-related genes and infiltrating immune cells was analyzed. We identified eight EMT-related lncRNAs in CAD. The area under curve value was greater than 0.95. The immune analysis revealed significant CD8 T cells, monocytes, and NK cells in CAD and found that EMT-related lncRNAs were correlated with these immune cell subsets. Moreover, SNAI2, an EMT-TF gene, was found in the trans-regulatory network of EMT-related lncRNAs. Further, we found SNAI2 as a biomarker for the diagnosis of CAD but it also had a close correlation with immune cell subsets in CAD. Eight EMT-related lncRNAs and SNAI2 have important significance in the diagnosis of CAD patients.
The crystal structure of bis(μ2-5-chloro-2-oxido-N-(1-oxidopropylidene)benzohydrazonato-κ5
N,O,O′:N′,O′′)-octakis(pyridine-κ1
N)trinickel(II) C60H56Cl2N12Ni3O6
Authors: Xin Wang , Liguo Yang , Yizhuo Dong , Yanlin Ye , Yifan Wang 
Published: April 2022

Abstract
C60H56Cl2N12Ni3O6, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 12.684(5) Å, b = 12.827(5) Å, c = 19.100(7) Å, α = 84.641(4)°, β = 81.178(4)°, γ = 85.471(4)°, V = 3050.7(19) Å3, Z = 2, R

gt
(F) = 0.0267, wR

ref
(F
2) = 0.0735, T = 298 K.
Electrical and Transport Properties of Cement Mortar Made Using Portland Limestone Cement
Authors: Choudhary Antara , Ghantous Rita M. , Bharadwaj Keshav , Opdahl Oliver Hudson , Isgor O. Burkan , Weiss W. Jason 
Published: April 2022

Abstract
This study examines the performance of cementitious systems made using clinker that is typically used to make Type II/V cement, limestone, and supplementary cementitious materials (SCMs). The porosity, formation factor, and pore connectivity of mortars are examined. The mortars are made with ordinary portland cement (OPC), OPC+limestone (LS), and portland limestone cement (PLC) with and without typical commercial SCMs (silica fume, fly ash, and slag). The porosity of both the PLC and OPC+LS mortars is approximately 4 % higher than the porosity of commercial OPC (which typically contains 2–3 % interground limestone) mortar. The porosity of PLC+SCM and OPC+LS+SCM mortars is also 2–6 % higher than the porosity of commercial OPC+ SCM mortars. The mixtures containing SCMs with alumina showed less of an increase in porosity because the limestone reacted with alumina to form carbo-aluminate reaction products. Despite the increase in porosity, there is no statistically significant difference between the formation factor of the PLC, OPC+LS, and OPC mortars without SCM. The PLC+SCM, OPC+LS+SCM, and OPC+SCM mortars had a higher formation factor than the plain OPC/PLC/OPC+LS mortars because of pore refinement. Pore refinement is also observed in PLC and OPC+LS mortars containing SCMs with alumina. The results of this study indicate that PLCs (ASTM C595/C595M-20, Standard Specification for Blended Hydraulic Cements) can be used as a direct replacement for OPCs (ASTM C150/C150M-20, Standard Specification for Portland Cement) without any significant reduction in performance as related to transport.
Analytical and Numerical Study of the Ring Expansion Testing Technique
Authors: Abdelgawad Khaled , Nassef Ahmed , Eraky Mohamed T. 
Published: April 2022

Abstract
This article presents a design development for the ring expansion test as an alternative technique of burst test to determine the mechanical properties of circular homogeneous thin-walled tubes in the hoop direction where it is supposed to fail. This is done by replacing the internal fluid pressure in burst test by a solid mandrel partitioned into an equal number of pieces. The numerical analyses were carried out using the commercial finite element method (FEM) package ABAQUS/CAE. The testing system consists of a multispecies mandrel assembled with two identical cones from top and bottom, and the ring specimen circumscribes the mandrel, which expands radially as a result of the cone’s axial displacement. The FEM was used to optimize the proposed design in terms of the minimum number of pieces in use. In addition, the effects of friction between the cones/the mandrel and between the ring/the mandrel are investigated. The FEM revealed that eight mandrel pieces or more are needed to preserve a uniform hoop stress throughout the ring circumference. Moreover, the FEM results in conjunction with theoretical formulas revealed that eight mandrel pieces at a minimum are required to minimize the power dissipated because of friction to a nuance value of 2 %. It is concluded that the higher the number of pieces used, the more uniform the hoop stress generated in the ring specimen. Moreover, it can effectively decrease friction effect at the ring/mandrel interface. The FEM also makes a great contribution in estimating the friction coefficients as it is restricted to be evaluated experimentally.
“It was a Shock to the Whole Family”: Challenges of Ukrainian Families Raising a Child with Autism
Authors: Semigina Tetyana , Stoliaryk Olha 
Published: April 2022

Based on the family-centered approach and a consumer perspective this research examines the overall level of satisfaction with educational and social services of the families raising children with autism or autism spectrum disorders (ASD) in Lviv (Ukraine) and the challenges in interactions of such families with services. The survey (90 parents who are social work clients) and individual semi-structured interviews (30 parents) were used.
The findings indicate the respondents’ evaluation of the services they receive and inclusive education could not be qualified as favorable. Key challenges identified within the study are: problems of staff preparedness and lack of information about services; personal feelings of emotional burnout; unrealistic expectations from services; social stigma related to autism and social isolation of parents raising a child with ASD.
It is important for social workers to consider the need to collaboratively create the so-called social routers for families raising children with developmental disabilities during the early stages of family work. Verified information may reduce the parents’ stress and consolidate their efforts, help to avoid dubious treatments that are detrimental to the child’s health and are a significant financial burden to the family.
Controlling the obesity pandemic: Geoffrey Rose revisited
Authors: Frank John W. 
Published: April 2022

AbstractThe ongoing obesity pandemic threatens the health of hundreds of millions globally. However, to date, no country has had much success in limiting its growth, let alone reversing it. This commentary demonstrates the relevance to the obesity pandemic of the public health conceptual framework of epidemiologist Geoffrey Rose, first published as “Sick Individuals and Sick Populations” in 1985. That framework provides a useful way to analyze the pandemic’s prevention and control options, based on the notions of primordial, primary, secondary and tertiary prevention—the full spectrum of “more upstream and more downstream” approaches, each with its pros and cons. Based on an analysis of key studies to date, this commentary argues strongly that only the primordial prevention approach is likely to be successful against the obesity pandemic—but its onerous requirements for society-wide behavioural and cultural change may make that public health struggle a long one.
Recursos psicosociales para la permanencia de los estudiantes de la Universidad de Antioquia
Authors: López Bedoya Julia Beatriz , Cardona Quitián Herwin Eduardo 
Published: April 2022

Este estudio es una aproximación reflexiva a los recursos psicosociales que favorecen la permanencia de estudiantes de los cuatro primeros semestres de diferentes programas académicos de la Universidad de Antioquia. Se sustenta metodológicamente en el modelo teórico del desarrollo positivo, el método cualitativo y el procedimiento hermenéutico. En el estudio participaron veinte estudiantes: diez mujeres y diez hombres, con edades entre dieciséis y veinte años; la información fue recogida en dos grupos focales y cuatro entrevistas individuales semiestructuradas. A lo largo del estudio se analiza la relación entre la permanencia y los recursos internos y externos derivados del apoyo familiar y la adecuada relación con los pares, la institución y la comunidad, todo ello con el fin de orientar programas para el bienestar estudiantil, desde las experiencias de los estudiantes.
Conservación de la atención a pesar de la privación de sueño en estudiantes de Psicología
Authors: Prado Rivera Mayerli Andrea , Morris Camacho Juliana Valentina , Martínez Díaz Laura Valentina , Sierra Ramírez Adriana Andrea 
Published: April 2022

El objetivo del estudio es identificar los efectos de privación total o parcial del sueño sobre una tarea de atención en 49 estudiantes de psicología de la Corporación Universitaria Minuto de Dios —Uniminuto—, quienes fueron asignados a uno de los cuatro grupos, con diferentes horas de sueño durante una noche. El día siguiente, al dormir el número de horas según el grupo respectivo (G1: 0 h; G2: 0,5-3 h; G3: 3,5-6 h; G4: > 6 h), cada participante diligenció una ficha de registro y realizó la prueba de atención sostenida d2. Se encontró que no existen diferencias entre grupos para ningún indicador, exceptuando el promedio de errores de comisión. Los estudiantes con privación parcial cometieron menos errores que aquellos con privación total y sin privación de sueño. Se discute si los patrones de sueño sumados a posibles mecanismos cerebrales compensatorios pueden mantener, a corto plazo, la capacidad atencional ante la privación de sueño.
PERIOPERATIVE INCIDENCE OF IATROGENIC GALLBLADDER PERFORATION DURING LAPAROSCOPIC CHOLECYSTECTOMY IN SULAIMANIYAH TEACHING HOSPITAL
Authors: Tofiq Sarkhel , Shareef Seerwan 
Published: April 2022

Background
Iatrogenic perforation of the gallbladder has been reported in 28% of those patients who undergo laparoscopic cholecystectomy. It has been pointed out that gallbladder perforation can result in spillage out gallstones and bile.
Objectives
To investigate the perioperative incidence of iatrogenic gallbladder perforation during laparoscopic cholecystectomy in Sulaimani Teaching Hospital.
Patients and Methods
The present investigation was a single-centre, prospective observational study that was carried out in Sulaimani Teaching Hospital in 2018-2019. The study sample included 99 patients who had undergone elective cholecystectomy by multiple surgeons.
Required data on the possible risk factors and early outcomes and the patients’ demographics, including age, BMI, and gender, were collected. The collected data were analyzed through the Statistical Package for the Social Sciences (version 22.0).
Results
The results revealed that 80% of the patients were females. Also, 42.4% had no chronic diseases. At the same time, diabetes mellitus (DM), DM along with hypertension (HT), and HT were the most prevalent chronic diseases among them with 18.2%, 16.2%, and 10.1% of prevalence, respectively. (Multiple attacks of cholestasis). Only 17.2% of the patients had an abdominal operation before, and acute cholestasis and chronic cholestasis were seen respectively in 13% and 17% of them. The most common causes of gallbladder perforation (GP) were found to be electrocautery (16.2%) and grasper (7.1%). 33.3% of the patients were overweight (BMI between 25 and 29.9), 45.5% were obese (BMI between 30 and 34.9), and 20.2% had a BMI of over 35. (Overweight or obese patients have a problematic view in laparoscopy) Most of the patients were aged 30 to 49 (62.6%). A majority of the patients (94.9%) were found to have gallstones.
Conclusion
Iatrogenic gallbladder perforation is prevalent among patients who undergo laparoscopic cholecystectomy. However, laparoscopic cholecystectomy is still a better choice and is associated with fewer complications than open cholecystectomy. Required measures need to be adopted for patients with perforated gallbladder to minimize spillage and remove as much spilt gallbladder content as possible.
Recent Surface Rupturing Earthquakes along the South Flank of the Greater Caucasus near Tbilisi, Georgia
Authors: Stahl Timothy A. , Cowgill Eric , Boichenko Giorgi , Vasey Dylan A. , Godoladze Tea 
Published: April 2022

ABSTRACTFault characterization is a critical step toward improving seismic hazard assessment in the Georgian Greater Caucasus but is largely absent from the region. Here, a paleoseismic trench near the capital city of Tbilisi revealed evidence for recurring surface rupture on a shallowly north-dipping thrust fault. The fault has broken through the overturned forelimb of a fault-propagation anticline that folds a sequence of soils and deposits. Stratigraphic relationships and radiocarbon dating of terrestrial gastropod shells corrected for “old carbon” age anomalies loosely constrain three surface-deforming earthquakes on this fault between ∼40 and ∼3 ka, with variable dip-slip displacements ranging between 0.35 and ∼3 m, and a cumulative displacement of 6.5 ± 0.85 m. Single event slips and recurrence intervals (11, 25, and 3 ka open interval) at this site demonstrate apparent slip rate variations of 3−7× over the last two earthquake cycles on the fault, which we attribute to possible rupture complexity involved in crustal thrust fault earthquakes. This study provides a structural and geochronologic template for future paleoseismic investigations in the Greater Caucasus while highlighting some of the challenges of conducting seismic source characterization in this region.
The Far Side of Mars: Two Distant Marsquakes Detected by InSight
Authors: Horleston Anna C. , Clinton John F. , Ceylan Savas , Giardini Domenico , Charalambous Constantinos , Irving Jessica C. E. , Lognonné Philippe , Stähler Simon C. , Zenhäusern Géraldine , Dahmen Nikolaj L. , Duran Cecilia , Kawamura Taichi , Khan Amir , Kim Doyeon , Plasman Matthieu , Euchner Fabian , Beghein Caroline , Beucler Éric , Huang Quancheng , Knapmeyer Martin , Knapmeyer-Endrun Brigitte , Lekić Vedran , Li Jiaqi , Perrin Clément , Schimmel Martin , Schmerr Nicholas C. , Stott Alexander E. , Stutzmann Eléonore , Teanby Nicholas A. , Xu Zongbo , Panning Mark , Banerdt William B. 
Published: April 2022

Abstract
For over three Earth years the Marsquake Service has been analyzing the data sent back from the Seismic Experiment for Interior Structure—the seismometer placed on the surface of Mars by NASA’s InSight lander. Although by October 2021, the Mars seismic catalog included 951 events, until recently all these events have been assessed as lying within a radius of 100° of InSight. Here we report two distant events that occurred within days of each other, located on the far side of Mars, giving us our first glimpse into Mars’ core shadow zone. The first event, recorded on 25 August 2021 (InSight sol 976), shows clear polarized arrivals that we interpret to be PP and SS phases at low frequencies and locates to Valles Marineris, 146° ± 7° from InSight. The second event, occurring on 18 September 2021 (sol 1000), has significantly more broadband energy with emergent PP and SS arrivals, and a weak phase arriving before PP that we interpret as Pdiff. Considering uncertain pick times and poorly constrained travel times for Pdiff, we estimate this event is at a distance between 107° and 147° from InSight. With magnitudes of MwMa 4.2 and 4.1, respectively, these are the largest seismic events recorded so far on Mars.
Effect of intravenous fentanyl versus intravenous fentanyl and paracetamol in attenuating the hemodynamic response to laryngoscopy and endotracheal intubation
Authors: Suresh Priyanka , Emani Aishwarya 
Published: April 2022

Laryngoscopy and endotracheal intubation are potent stimuli causing increased sympathoadrenal activity. The objective of this study is to assess and compare the effects of intravenous fentanyl versus a combination of intravenous fentanyl and paracetamol in blunting the hemodynamic responses to laryngoscopy and endotracheal intubation. Sixty patients of ASA status I and II, aged 18-60 years of either sex posted for surgeries under general anaesthesia were selected. Patients in group A received intravenous fentanyl 2mcg/kg. Patients in group B received intravenous fentanyl 2mcg/kg and paracetamol 15mg/kg. After intubation vital parameters were recorded at 1, 2, 4 and 6 minute and later once every 10minutes.: After intubation, there was an initial increase in heart rate in both groups. However, this was significantly higher (p=0.004) with group A as compared to group B and remained significantly high for another 6 minutes(p=0.03).There was an increase of mean arterial pressure after intubation in both the groups, however, this was significantly higher in group A and remained significantly high for 6 minutes as compared to group B[p=0.003]. Mean SpO2 was similar in both the groups, and there were no complications during the study. Intravenous fentanyl and paracetamol is more effective in blunting the hemodynamic responses due to laryngoscopy and endotracheal intubation when compared to intravenous fentanyl alone.
Comparison of intrathecal tramadol and Magnesium sulphate for the prevention of post-spinal shivering in infra umbilical surgeries: A randomized, double blinded and controlled study
Authors: Poovathai Raja , Sundararaju Sathis C , Ramalingam Kadirvelu S 
Published: April 2022

: Post anesthesia shivering is a common complication after spinal anesthesia. Intrathecal Magnesium sulphate (MgSO4) and tramadol are the most effective and safe adjuvants with minimal side effects. The aim of this study was to compare the effect of intrathecal tramadol versus intrathecal MgSO4 with bupivacaine for the prevention of post-spinal anesthesia shivering. : In this prospective randomized, double-blinded controlled study, 105 patients scheduled for infraumbilical surgeries were randomly allocated into three groups. Group C(35) received 3.0ml of hyperbaric bupivacaine 0.5% (15mg)+0.5ml of normal saline, Group T (35) received 3.0ml of hyperbaric bupivacaine 0.5% (15mg)+25mg of tramadol in 0.5ml saline, and Group M (35) received 3.0ml of hyperbaric bupivacaine 0.5% (15mg)+100mg of magnesium sulphate in 0.5ml saline. The primary outcomes were to find the incidence and intensity of shivering. The secondary outcome was to find out the incidence of complications.: All the 3 groups were comparable with respect to demographic characteristics. Shivering was observed in 68.6% of the patients in Group C, 48.6% patients in Group T and 40% patients in Group M. The incidence of shivering were statistically significant between Groups C and T (P= 0.003) and Groups C and M (P=0.001) but not between Groups T and M (P=0.480). The incidence of complications such as hypotension, bradycardia, nausea, vomiting,itching and respiratory depression were not statistically significant in between the groups.: This study concluded that both intrathecal MgSO4 100mg and tramadol 25mg with hyperbaric bupivacaine reduces the incidence and intensity of shivering compared to control group after spinal anesthesia.
Comparative evaluation of incidence of post operative sore throat after nebulization with ketamine and magnesium sulfate in patients undergoing general anaesthesia requiring endotracheal intubation
Authors: Dhuliya Sandeep , Patel Neepa , Shah Divyang 
Published: April 2022

Post-operative pharyngeal discomfort or sore throat is unavoidable outcome of endotracheal intubation. There are some pharmacological and non-pharmacological methods for prevention of postoperative sore throat. Nebulization is better than gargle or other methods as small volume of drug required for effect, easy way of administration, better patient compliance and most importantly no risk of aspiration as seen with gargle. In our study, 88 patients of ASA grading I- Ⅲ, aged between 18-65 years undergoing general anaesthesia on elective basis were randomly divided into two groups. 44 patients received pre-operative nebulization with 1ml ketamine(50mg) with 1ml normal saline while others received nebulization with 500mg Magnesium sulfate with 1ml normal saline. General anaesthesia was given. Number of intubation attempts, duration of laryngoscopy and duration of surgery were recorded. Patients were evaluated for post-operative sore throat, hoarseness of voice and cough at 0hr, 2hr, 4hr, 12hr, and 24hr in postoperative period. Incidence of post-operative sore throat, cough and hoarseness of voice was reduced statistically significantly with ketamine nebulization when compared to magnesium sulphate nebulization (p=&#60;0.05). There were no systemic side effects with any drug. Ketamine nebulization was superior than magnesium nebulization in prevention of sore throat.
Foreign direct investments in U.S. agricultural land
Authors: Korotkikh Alla 
Published: April 2022

U.S. agricultural land remains attractive to foreign investors. As of December 31, 2020, foreign direct investment in this property amounted to $4.5 million, which is three times higher than in 2014. Foreign individuals and companies currently held an interest in nearly 15.2 million hectares of US agricultural land. This represents 2.9 percent of all privately owned agricultural land in the United States.
Almost half of the reported foreign interest holdings of U.S. land are arable land and pastures, with timber and forestland accounting for 46 percent of the total acreage, which are mainly used by timber and &quot;green&quot; energy companies.
Canadian investors own the largest amount of reported foreign-held agricultural land, with 32 percent. Foreign persons from an additional four countries, the Netherlands, Italy, the United Kingdom, and Germany collectively held 31 percent of the foreign-held acreages in the United States.
The state of Texas has the largest amount of foreign-held U.S. agricultural land. Maine has the second, Alabama - the third largest amount of foreign-held agricultural land. Three states collectively held more than 25% of the reported foreign-held agricultural land in the United States, the vast majority of which is forestland.
Current law imposes no restrictions on the amount of private U.S. agricultural land that can be foreign owned. However, several states have imposed certain prohibitions or restrictions on foreign ownership, but do not significantly inhibit foreign farmland ownership, while most states expressly allow foreign ownership.
The US government controls direct investment flows. Federal law requires foreign persons and entities to disclose to USDA information related to foreign investment and ownership of U.S. agricultural land. The Agricultural Foreign Investment Disclosure Act of 1978 (AFIDA) and its federal regulations, implemented by USDA, established a nationwide system for the collection of information pertaining to foreign ownership of U.S. agricultural land. At the federal level, the Committee on Foreign Investment (CFIUS) authorized to review certain transactions involving foreign investment in the United States in order to determine the effect of such transactions on U.S. national security.