bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-Reported Outcome Dashboards Within the Electronic Health Record to Support Shared Decision-making: Protocol for Co-design and Clinical Evaluation With Patients With Advanced Cancer and Chronic Kidney Disease
Authors: Perry Laura M , Morken Victoria , Peipert John D , Yanez Betina , Garcia Sofia F , Barnard Cynthia , Hirschhorn Lisa R , Linder Jeffrey A , Jordan Neil , Ackermann Ronald T , Harris Alexandra , Kircher Sheetal , Mohindra Nisha , Aggarwal Vikram , Frazier Rebecca , Coughlin Ava , Bedjeti Katy , Weitzel Melissa , Nelson Eugene C , Elwyn Glyn , Van Citters Aricca D , O'Connor Mary , Cella David 
Published: September 2022

Background
Patient-reported outcomes—symptoms, treatment side effects, and health-related quality of life—are important to consider in chronic illness care. The increasing availability of health IT to collect patient-reported outcomes and integrate results within the electronic health record provides an unprecedented opportunity to support patients’ symptom monitoring, shared decision-making, and effective use of the health care system.

Objective
The objectives of this study are to co-design a dashboard that displays patient-reported outcomes along with other clinical data (eg, laboratory tests, medications, and appointments) within an electronic health record and conduct a longitudinal demonstration trial to evaluate whether the dashboard is associated with improved shared decision-making and disease management outcomes.

Methods
Co-design teams comprising study investigators, patients with advanced cancer or chronic kidney disease, their care partners, and their clinicians will collaborate to develop the dashboard. Investigators will work with clinic staff to implement the co-designed dashboard for clinical testing during a demonstration trial. The primary outcome of the demonstration trial is whether the quality of shared decision-making increases from baseline to the 3-month follow-up. Secondary outcomes include longitudinal changes in satisfaction with care, self-efficacy in managing treatments and symptoms, health-related quality of life, and use of costly and potentially avoidable health care services. Implementation outcomes (ie, fidelity, appropriateness, acceptability, feasibility, reach, adoption, and sustainability) during the co-design process and demonstration trial will also be collected and summarized.

Results
The dashboard co-design process was completed in May 2020, and data collection for the demonstration trial is anticipated to be completed by the end of July 2022. The results will be disseminated in at least one manuscript per study objective.

Conclusions
This protocol combines stakeholder engagement, health care coproduction frameworks, and health IT to develop a clinically feasible model of person-centered care delivery. The results will inform our current understanding of how best to integrate patient-reported outcome measures into clinical workflows to improve outcomes and reduce the burden of chronic disease on patients and health care systems.

International Registered Report Identifier (IRRID)
DERR1-10.2196/38461
A NOVEL RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF A POTENTIAL ANTI-DIABETIC DRUG METFORMIN HYDROCHLORIDE IN TABLET DOSAGE FORM
Authors: HIREMATH JAYASHREE A. , KUMAR HARISH 
Published: September 2022

Objective: This study was conducted to develop a simple, economical, linear, rapid method for the assay studies of Metformin HCl by RP-HPLC method and to carry out the method validation.
Methods: A simple, robust and accurate method to carryout assay of Metformin hydrochloride tablet(500 mg) by RP-HPLC method in which the stationary phase used is Shimadzu shim-pack GIST C18 column with specification (5μm×4.6×250 mm). This method involves isocratic elution of mobile phase containing 70% buffer and 30% acetonitrile. The buffer used for analysis is Tetra-Butyl Ammonium Hydroxide (0.002%), the flow rate was maintained at 0.5 ml/min. detection was done at 232 nm. Principal peak for Metformin was observed at 3.5 min and the runtime for each injection was set to 10 min. The standard solutions of Metformin were prepared using purified water (milli-Q water) and scanned from 190 nm to 400 nm. Sharp peaks were observed in the range of 232 nm and thus, wavelength of 232 nm was selected and used throughout the validation process.
Results: Linearity graph generated was found acceptable and accurate and the graph was generated in the range of 50% to 150% concentration. The regression coefficient was found to be 0.999(acceptable range). Validation was carried out according to ICH guidelines and found to be acceptable.
Conclusion: This developed method was found to be simple, robust, economical, accurate, linear and can be used in the assay of Metformin tablet using RP-HPLC.
The Association of High COVID-19 Cases and Mortality with Anomalous High Surface Ozone Concentration in Moscow City in Summer 2021
Authors: Stepanov E. V. , Andreev V. V. , Chuprov D. V. , Ivashkin V. T. 
Published: September 2022

Aim: to compare statistical data on the frequency of COVID-19 and deaths from it with the ozone content in the surface atmosphere of Moscow in the summer of 2021.Materials and methods. We used data on the frequency of daily COVID-19 cases and mortality from COVID-19 in Moscow in 2020–2021 published by Rospotrebnadzor. Data on the ozone content in the surface layer of the atmosphere were obtained by an automatic monitoring station using a chemiluminescent analyzer.Results. The waves of high frequency of COVID-19 cases and mortality from COVID-19 in Moscow in the summer of 2021 were compared with abnormally high concentrations of ozone in the surface atmosphere of the megalopolis. Variations of these parameters were found to be markedly correlated. The coefficients of correlation of the COVID-19 cases and mortality with the concentration of ground-level ozone were 0,59 (p < 0.01) and 0.60 (p < 0.01), respectively.Conclusion. The observed noticeable relationship may be due to the combined pathological effect of high concentrations of ozone and the SARS-CoV-2 on the respiratory and circulatory organs, which can lead to both easier transmission of infection and a more severe course of the disease with increased mortality.
Prevalence of Small Intestinal Bacterial Overgrowth Syndrome in Patients with Irritable Bowel Syndrome who Have Suffered COVID-19
Authors: Nalyotov A. V. , Guz N. P. 
Published: September 2022

Aim. To study the prevalence of the small intestinal bacterial overgrowth syndrome in patients with irritable bowel syndrome with diarrhea who have had COVID-19 infection.Materials and methods. 60 patients with irritable bowel syndrome with diarrhea were examined. In 30 patients, irritable bowel syndrome was diagnosed after COVID-19 infection (main group). The comparison group consisted of 30 patients with classical stress-induced irritable bowel syndrome. The small intestinal bacterial overgrowth syndrome was diagnosed using a hydrogen breath test with lactulose loading in all patients.Results. In main group the small intestinal bacterial overgrowth syndrome was diagnosed in 93.3 % patients, which was statistically significantly higher (p < 0.01) relative to the comparison group — 60.0 % patientsConclusion. Irritable bowel syndrome in patients who have undergone COVID-19 occurs against the background of the small intestinal bacterial overgrowth syndrome development.
Modern Approaches to Vaccination of Patients with Chronic Liver Diseases and Inflammatory Bowel Diseases against a Novel Coronavirus Infection
Authors: Sheptulin A. A. , Ivashkin V. T. 
Published: September 2022

Aim. To analyze the literature data on the peculiarities of vaccination of patients with chronic liver diseases (CLD) and inflammatory bowel diseases (IBD) against COVID-19 infection.Key findings. It has been shown that many patients with CLD (cirrhosis of the liver, non-alcoholic fatty liver disease) have a higher risk of severe course of a novel coronavirus infection, which necessitates their vaccination. IBD patients are also subject to vaccination, although the immunomodulatory drugs which they take may reduce its effectiveness. In addition, the correct timing of the vaccine administration is of great importance. Vaccination of patients with CLD and IBD is safe, and the frequency of side effects during its implementation does not differ from that in the general population.Conclusion. Analysis of literature data shows that patients with CLD and IBD are subject to vaccination against COVID-19 infection, which is effective and safe.
Pelatihan dan Pembuatan Video Pembelajaran pada TK AL-Islam Tambak Bayan Yogyakarta
Authors: Hetty Primasari Clara , Sitepu Roberto Reno , Virgi Yandi Saputra Lutgarda , Suryo Prayogo Thomas Edwin , Hansel Emmanuel , Odie Kristiawan Bernardinus , Wahyu Sedana I Gede 
Published: September 2022

Pengabdian ini di latar belakangi oleh kesulitan dalam mengajar di era pandemi yang membuat para guru harus mengadaptasi seluruh kegiatan belajar mengajar menjadi daring. Adaptasi pembelajaran secara daring menjadi tantangan tersendiri khususnya bagi guru TK AL-Islam Tambak Bayan. Siswa TK masih belum bisa memahami kompleksitas yang ada pada pembelajaran secara daring. Oleh karena itu, banyak metode yang kurang cocok dan ketidakmampuan guru dalam menerapkan teknologi informasi dalam kegiatan belajar mengajar. Hal ini menyebabkan kegiatan belajar mengajar menjadi seadanya saja sehingga tidak dapat berjalan dengan baik. Tujuan pengabdian ini yakni untuk membantu serta melatih guru TK AL-Islam Tambak Bayan dalam menyajikan materi pembelajaran melalui video animasi yang menarik sehingga siswa TK memiliki kemauan untuk belajar. Metode yang digunakan yaitu pelatihan dan pembuatan video pembelajaran dengan menggunakan Animaker, untuk kemudian video tersebut dapat diakses secara daring. Hasil yang didapatkan dari pengabdian ini adalah para guru TK AL-Islam Tambak Bayan mampu memahami fitur dan cara menggunakan Animaker serta dapat membuat video pembelajaran animasi yang menarik dan mudah dipahami bagi murid TK.
Analisis Kadar Rada'ah yang Mengharamkan Pernikahan Dalam Perspektif Hukum Islam
Authors: Adminfamilia Ali Zainal Abidin 
Published: September 2022

Salah satu makanan terbaik yang dianugrahkan oleh Allah SWT adalah asi buat seorang bayi melalui perantara seorang ibu agar dapat terjamin kelangsungan hidupnya dikemudian hari, dan perempuan yang menyusukan tersebut menjadi ibunya dan diharamkan pernikahan denganya dan segenap keturunannya, itu konsekuensi atau efek hukum yang diatur oleh syariat. Perdebatan para ulama mazhab jumhur dan ibn hazm dan mazhab syafii dan mazhab imam ahmad bin hanbal, pasalnya apakah hubungan susuan terjadi seketika ketika bayi minum susu wanita? Jawabannya tidak karena harus melihat kadar susuan yang diminum bayi tersebut dan berapakah umur bayi yang menyusui? beberapa dalil dari al-Quran dan Hadis yang masih menjadi perdebatan di kalangan ulama dalam membahas masalah ini.
Manifestations of ENT Caused By Gastroesophageal Reflux Disease
Authors: Andreea Hagi , Gurgas Leonard , Victor Lupascu Mihai 
Published: September 2022

Abstract
Introduction. The presence of gastric reflux in the pharynx and larynx causes reflux laryngopharyngitis. The incidence of laryngopharyngeal reflux has increased dramatically in recent years, but with the introduction of flexible fiber optic esophagoscopy, evidence-based research on gastroesophageal reflux disease has evolved greatly. Laryngoscopy is the main investigation to be performed to establish the diagnosis of reflux.
Material and methods. This study is both retrospective and prospective, the first being performed on a group of 175 patients, who presented in the ENT outpatient clinic, within the County Emergency Clinical Hospital “St. Andrew the Apostle” Constanta.
The aim of this paper is to evaluate and compare the manifestations of ENT caused by reflux disease but also to establish the correct therapeutic conduct.
Polarized Microscopy Study of 10 Cases of Lichen Sclerosus Using Picro-Sirius Red Stain
Authors: Liliana Mocanu , Elena Munteanu-David Ramona , Sorin Deacu 
Published: September 2022

Abstract
Lichen sclerosus (LS) is a chronic mucocutaneous sclerosis most commonly affecting the genital area, although extragenital localizations have also been described1, with unknown pathogenesis.
Our study aims to analyze the morphopathological aspects of LS through the prism of polarized microscopy and with the help of histochemical information provided by special Van Gieson stain for elastic tissue and Picro-Sirius Red special stain.
Picro-Sirius Red staining allows observation of the type of collagen synthesized in pathological conditions such as LS, as well as the appearance of mature hyalinization through loss of elastic tissue, and also the disappearing of piloerectile muscles.
Does the Death Anxiety of Nurses Providing Care for Patients with Covid-19 Affect their Commitment to the Profession? A Correlational Descriptive Study
Authors: Güven Şefika Dilek 
Published: September 2022

Nurses make up the largest group of healthcare professionals fighting Covid-19, and they frequently face patients with Covid-19 from hospitalisation to discharge. For this reason, they are exposed to several psychological pressures and occupational hazards. This study aimed to determine the relationship between death anxiety and commitment to the profession in nurses providing nursing care for patients with Covid-19 in Turkey. A correlational descriptive study was conducted with 130 nurses giving nursing care to patients with Covid-19 in a hospital in Turkey providing care to Covid-19 patients. A personal information form, the Turkish Death Anxiety Scale, and the Nursing Professional Commitment Scale were used to collect the study data. Descriptive statistical methods were used to summarise the general information. The data are expressed as “mean ± standard deviation (X ± SD)” or “frequency and percentage.” Correlations between the scales were determined using Spearman’s correlation test. The statistical significance level was accepted as p < 05. The mean score of nurses from the Turkish Death Anxiety Scale was 76.00 ± 23.44, and their mean score from the Nursing Professional Commitment Scale was 57.00 ± 14.60. No significant relationship was found between the Turkish Death Anxiety Scale and the Nursing Professional Commitment Scale scores (r = 0.085, p = .336). The findings of the study showed that nurses had a high death anxiety level, their commitment to the profession was moderate, and that no significant relationship was found between their death anxiety and commitment to the profession. Nurses should be supported by employers to enhance their professional commitment and reduce death anxiety during the Covid-19 pandemic.
Fostering Clinical Judgement Ability among Nursing Students by Application of Concept Mapping in the City of Bangalore, India
Authors: Joseph Jasmine , Ravi Hemalatha 
Published: September 2022

Each clinical encounter demands competent clinical skills and expertise from a student nurse. This period also becomes the most challenging as many have trouble linking theory with practice. Thus, they experience less confidence at the bedside of patients. Delivering high-quality, safe nursing care at the bedside requires sound clinical judgement. Nurses with clinical judgement have evidence-based knowledge enabling them to identify intuitively salient patient care information and respond accordingly. Developing these critical clinical judgement abilities takes time, and many new nurses lack them. Concept mapping is a robust instructional technique that may assist novice nurses in making links between many aspects of nursing care concepts, allowing for the development of clinical judgement. This study aimed to determine the usefulness of the concept mapping approach to foster clinical judgement among nursing students in Bangalore, India. A quantitative, quasi-experimental pretest-post-test design with a control group was implemented among Bachelor of Science in Nursing students. The subjects were undergoing medical-surgical nursing courses in four nursing colleges in an urban setting. The allocation of four colleges to the control and experimental group was random. A sample size of 300 participants completed a questionnaire on baseline characteristics and the Lasater Clinical Judgement Rubric. The experimental group was taught using the concept mapping technique, and participants prepared a concept map for their assigned patient in the clinical area. The intervention group’s mean pretest clinical judgement score was 18.24 (SD = 3.17), while the control group’s was 20.18 (SD = 4.85). The intervention group’s mean post-test clinical judgement score (29.56, SD = 5.42) is greater than the control group’s (22.33, SD = 4.63). The experimental group had a substantially higher post-test clinical judgement score (t = 3.99, P<0.001) than the control group. The findings imply that concept mapping will help nursing students improve their clinical judgement abilities.
Students’ Digital Readiness for – and Satisfaction with – Online Learning: A Case Study of the University of KwaZulu-Natal, South Africa
Authors: Subban Mogie , Soni Sanjay , Padayachee Indira 
Published: September 2022

The Covid-19 (acronym for the coronavirus disease of 2019) pandemic has signalled significance for online teaching and learning in higher education institutions (HEIs) both locally and internationally. This article reports on an empirically approved study that aimed to assess students’ digital readiness for online learning at the University of KwaZulu-Natal (UKZN), South Africa. The article presents the main areas examined to assess intrinsic and extrinsic factors influencing students’ online readiness with respect to their technical requirements; engagement with learning tools and resources; digital readiness; and satisfaction with the Moodle (acronym for Modular Object-Oriented Dynamic Learning Environment) online learning tool. Understanding students’ online learning readiness was deemed necessary for assisting UKZN in understanding such interventions and making improvements. The study drew on 400 students’ responses to a descriptive research design questionnaire to collect data from convenience-based purposive sampling. The constructs under study were measured for reliability using Cronbach’s alpha. The results indicated that most of the students used laptops to access learning resources, followed by smartphones. Technically, the students did not express difficulties with reliable electricity supply access and university data packages, but the noted deficiencies of network coverage, internet connectivity and provision of specialised software. While the students seemed ready to engage learning tools, nevertheless improvements could be made in participating in discussion forums and working in groups. Moodle received strong support, particularly for its continuous availability and flexibility. Interestingly, the study showed that the students were digitally ready for online learning, barring some improvement areas for readiness, although wider perspectives in tracking online learning are envisaged.
A Parenting Skills Programme to Enhance School Readiness of Grade R Learners in South Africa: A Social Work Perspective
Authors: Brown Jeanne , Van der Merwe Mariette 
Published: September 2022

Parenting plays a determining role in the development of school readiness. Socio-economic adversity often has a detrimental effect on the quality of parenting, which in turn has a negative impact on the school readiness of children. Intervention research was done to develop and implement a parenting skills programme for parents of Grade R learners in two resource-poor communities in South Africa. The findings indicate that parents can improve in the important areas of parenting, namely, the quality of the parent–child relationship, parent–child interaction, and creating a home-learning environment that could enhance the school readiness of their Grade R children. Social workers are in the ideal position to implement such a parenting skills programme. It will be part of their preventive work to limit later psychosocial problems in clients linked to lack of schooling, behavioural problems and unemployment.
The eye wash technique: A simple and effective technique for intraoperative ocular surface lavage
Authors: Rosatelli Neto 
Published: September 2022

Objectives:
The author proposes an extremely effective and practical method of ocular surface hydrating and cleaning during anterior segment surgery, the Eye Wash Technique (EWT), in substitution for the traditional methods employing a syringe and cannula for ocular irrigation.

Materials and Methods:
The EWT utilizes the intraocular irrigating solution (IS) used in the surgery. It is performed by employing the irrigating line of the phacoemulsification (phaco) machine or the irrigating fluid IV drip in case of manual cataract surgery. The eye irrigation is performed directly from the Luer end attachment of these irrigating lines, which is positioned above the inner cantus pointing to the globe’s nasal limbal region. With the phaco machine pedal in position 1 (irrigation only) or in panel continuous irrigation mode in case of phaco surgery, or by opening the roller clamp of the IV drip line in case of manual surgery, IS flow ensues and is directed to the eye from a nasal direction to provide a steady flow to wash the exposed eye surface as well as the lid margins and lid speculum. The irrigation is maintained for two to five seconds with side-to-side jiggling if needed, to ensure complete ocular surface coverage. Cornea hydration is achieved and any unwanted material on the ocular surface is washed out.

Results:
The EWT was easily incorporated into the surgical routine with no difficulty in adaptation to the technique or in its employment. The surgical time was not prolonged when employing the technique. The EWT effectively provided both corneal hydration and ocular surface cleaning every time it was used, with no need to resort to the traditional syringe and cannula irrigation method at any time.

Conclusion:
The EWT should be incorporated into the anterior segment surgical routine and performed at the beginning of surgery, before inserting the intraocular lens, and at the end of the surgery; also, at any time during surgery should the need arise, enhancing anterior segment surgical visualization and safety.