bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Level of Sustainability Reporting of Malaysian IPO Companies
Authors: Abbas Yasir Abdullah , Mehmood Waqas , Manhal Mohammed H. , Aman-Ullah Attia 
Published: March 2022

Abstract
Purpose –
This paper aims to determine the level of sustainability reporting (SR) in Malaysian initial public offering (IPO) companies. Due to the general poor awareness about SR and its dimensions, these aspects have not been receiving the necessary push from the public domain.
Design/methodology/approach –
This study is exploratory in nature employing secondary data through the content analysis of the annual reports of 139 sampled IPOs listed on Bursa Malaysia for the period of 2007–2017. The data was analysed using descriptive statistics, whilst extent and quality were used as measures of SR.
Findings –
The results show that the extent and quality of SR in Malaysian IPO companies have improved over the years with a small improvement from one year to the next. The extent of SR was at 20.70% with society disclosure at 32.77% and energy disclosure at 22.48%, while employee disclosure showed the highest prevalence at 34.87% and product disclosure recorded the lowest prevalence at 9.88%. The quality of SR was at 32.04% with society disclosure recording the highest prevalence at 36.09%, energy disclosure at 20.28%, employee disclosure at 34.13%, and finally product disclosure indicating the lowest prevalence at 9.50%.
Research limitations/implications –
The dimensions of SR namely society, energy, employee, and product issues received little interest from most of the companies. This study proposes the need for additional studies investigating SR in IPO companies.
Originality/value –
This study makes a significant contribution to the information related to SR in Malaysian IPO companies. The findings can facilitate financial institutions and regulatory agencies in driving responsibility on the part of companies regarding SR issues.
A multifaceted strategy to improve recombinant expression and structure determination of complex proteins: A Trypanosoma surface protein as an example
Authors: Sülzen Hagen , Votrubova Jitka , Dhillon Arun , Zoll Sebastian 
Published: March 2022

Abstract
Identification of a protein minimal fragment amenable to crystallisation can be time- and labour intensive especially if large amounts are required and the protein has a complex fold and functionally important post-translational modifications. In addition, a lack of homologues and structural information can further complicate the design of a minimal expression construct. Recombinant expression in E. coli promises high yields, low costs and fast turnover times, but falls short for many extracellular, eukaryotic proteins. Eukaryotic expression systems provide an alternative but are costly, slow and require special handling and equipment. Using a member of a structurally uncharacterized, eukaryotic receptor family as an example we employ hydrogen-deuterium exchange mass spectrometry (HDX-MS) guided construct design in conjunction with truncation scanning and targeted expression host switching to identify a minimal expression construct that can be produced with high yields and low costs.
Wood quality of Astronium fraxinifolium and Enterolobium gummiferum for charcoal production
Authors: Santos Vaniele Bento dos , Baraúna Edy Eime Pereira , Colen Fernando , Baldin Talita , Monteiro Thiago Campos , Arantes Marina Donária Chaves 
Published: March 2022

Abstract
This paper aimed to evaluate the quality of wood and charcoal of Astronium fraxinifolium and Enterolobium gummiferum from Brazilian savannas (Cerrado). Discs from three trees of each species were removed at a height of 1.30 m above ground level. The samples were prepared for the analysis of the energy density and chemical components of the wood and for the production of charcoal at two final carbonization temperatures (350 and 450 ºC). After characterizing the charcoal, the carbonization yield and charcoal productivity per unit of wood volume were calculated. The wood of native species had potential for energy purposes. E. gummiferum charcoal stood out for its low ash content, and A. fraxinifolium wood presented higher apparent density and, consequently, higher carbonization yield and charcoal productivity per unit of wood volume. Charcoals produced at the two final carbonization temperatures presented adequate parameters for the steel industry and domestic use. The final temperature of 350 ºC is indicated as it presents higher gravimetric yield and energy yield of carbonization.
Efficacy and safety of different neoadjuvant radiation doses in patients with local advanced rectal cancer：A retrospective study
Authors: Xu Yuyan , Zou Haizhou , Shao Zhenyong , Zhang Xuebang , Ren XiaoLin , He Huijuan , Zhang Dahai , Du Dexi , Zou Changlin 
Published: March 2022

Abstract
Background: The research aimed to evaluate the efficacy and safety of different radiation doses (45Gy and 50.4Gy) on neoadjuvant in patients with LARC.Methods: Patients with LARC between January 2016 and June 2021 were retrospectively enrolled in the study, all of them underwent neoadjuvant chemoradiotherapy and radical surgical. XELOX regimen was administered for two cycles before nCRT. 72 patients received radiation dose with 50.4Gy while 45 patients with 45Gy. During radiotherapy, concurrent chemotherapy was employed as capecitabine alone. Surgery was performed within 5-12 weeks after nCRT.Results: Baseline characteristics in both groups were not statistically significant. The rate of well pathological regression in the 50.4Gy group was 59.72% (43/72) while in the 45Gy group was 64.58% (31/48) (P>0.05). The rate of radiographic remission in the 50.4Gy group was 70.83% (51/72), compared with 68.75% (33/48) in the 45Gy group(P>0.05). Significant differences existed in the incidence of several adverse events (radioactive proctitis, myelosuppression and intestinal obstruction or perforation) between the 50.4Gy group and the 45Gy group(P<0.05).Conclusions: Higher radiation dose could increase the incidence of several adverse events, meanwhile, it failed to improve the rate of pathological regression and imaging remission.
Roseomonas rosulenta sp. nov., isolated from rice paddy soil
Authors: Lee Hyo-Jin , Whang Kyung-Sook 
Published: March 2022

Abstract
Three bacterial isolates, Gram-stain-negative, non-motile, coccobacilli-shaped bacteria, strains OP-27T, OP-5 and OP-30, were isolated from rice paddy soil. Phylogenetic analyses based on 16S rRNA gene sequences revealed that three isolates belonged to the genus Roseomonas, showing the highest sequence similarities to Roseomonas sediminicola FW-3T (98.1%), Roseomonas lacus TH-G33T (98.0%), Roseomonas soli 5N26 T (97.8%), Roseomonas eburnea BUT-5T (97.5%), Roseomonas alkaliterrae YIM 78007T (97.4%), Roseomonas oryzicola YC6724T (97.4%), Roseomonas rubea MO17T (97.4%) and Roseomonas terrae DS-48T (97.1%) and less than 94.3% similarities to other species of the genus Roseomonas. The genome size of strain OP-27T was 5.2 Mb in a single contig with DNA G+C content of 71.2%. The genome included 5164 predicted protein-coding genes, as well as 48 tRNA, 4 rRNA and 4 mRNA genes. The average nucleotide identity value between strain OP-27T and type strains of related species of the genus Roseomonas were 81.1-83.1%, and the digital DNA–DNA hybridization values of strain OP-27T and the related strains were 24.6~26.8%, respectively. The DNA–DNA hybridization values between strains OP-27T, OP-5 and OP-30 were 84-100% and its closest relative, Roseomonas sediminicola KACC 16616T was 21.1%. The major fatty acids were C18:1 ω7c, C18:1 2-OH and C16:0 and predominant quinone was Q-10. Based on its distinctive phenotypic, phylogenetic, and chemotaxonomic characteristics, the three strains are considered to represent novel species of the genus Roseomonas, for which the name for which the name Roseomonas rosulenta sp. nov. is proposed. The type strain is OP-27T (=KACC 21501T=NBRC 114497T).
Abemaciclib plus fulvestrant for the treatment of hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer with cystic brain metastases: a case report and literature review
Authors: chu zhaohui 
Published: March 2022

Abstract
Cystic brain metastases in patients with breast cancer are rare. They have a worse prognosis than solid brain metastases, and they are less sensitive to radiotherapy. We report a case of hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) metastatic breast cancer with cystic brain metastases. The patient underwent treatment with docetaxel combined with capecitabine for 5 months, followed by anastrozole maintenance therapy for 10 months and palbociclib combined with exemestane for 22 months. Cystic brain metastases emerged and bone metastases increased in number. A missense mutation in PIK3CA (exon 10, c.1633G > A [p.Glu545Lys]) was detected by whole-exome next-generation sequencing of peripheral blood samples. After whole-brain radiotherapy (40 Gy/20 fx) combined with 3 months of treatment with everolimus and fulvestrant, cystic brain metastases demonstrated partial regression (PR), but extracranial bone metastases continued to increase in number. Thus, the patient underwent fourth-line treatment with abemaciclib (100 mg bid) combined with fulvestrant (500 mg). Three months later, cystic brain metastases significantly demonstrated PR and extracranial bone metastases were stable, without obvious adverse effects. This is the first report of abemaciclib combined with fulvestrant in the treatment of cystic brain metastases in a patient with HR+/HER2 − breast cancer.
A Geospatial Analysis of the Relationship Between Land Surface Temperature and Land Use/Land Cover Indices in Raiganj Municipality, West Bengal, India
Authors: Sarkar Bapi , Patra Sribas 
Published: March 2022

Abstract
The current research focuses on estimating land surface temperature (LST) in Raiganj Municipality, India, with their relationships of different land use and land cover (LULC) indices such as Normalized difference vegetation index (NDVI), Normalized difference water index (NDWI), and normalized difference built-up index (NDBI). Data were pre-processing Using ERDAS Imagine 14 and Arc GIS 10.3 software for layer stacking, mosaicking and clipping of the Landsat images. The analysis was based on Landsat TM 5 and Landsat 8 OLI satellite images of 2001, 2011, and 2021.The study observed that the values of LST, and NDBI were increased by 0.9˚C, and 0.71 from 2001 to 2021. And the values of NDVI, and NDWI were decreased by -0.20, and − 0.34 from 2001 to 2011. High land surface temperature is primarily located on the buildup area and LST level is low significantly due to the presence of vegetation and water bodies. The result indicates relationship between LST and the LULC indices, while LST has a significant positive association with NDBI, while NDVI and NDWI have a moderate to strong negative correlation. The study also found that changing land surface temperature has a significant influence on the ecosystem and loss of green space.
RECTAL LYMPHOMA: A RARE CASE REPORT WITH REVIEW OF LITERATURE
Authors: . Sunigdha , Kang Manraj S , Garg Pardeep , Banipal Raja P S , Gupta Neha 
Published: March 2022

Introduction: Colorectal lymphoma is an extremely rare disease. The disease is usually
diagnosed in the advanced stages because of its primary nonspecific symptoms. Treatment
modality of primary lymphoma of the rectum remains uncertain.
Case History: A 45-year-old male presented with rectal bleeding, pain in perianal region and
alteration in bowel habits along with fungating and circumferential mass in the rectum. The
histopathology and immunohistochemistry confirmed the diagnosis of Plasmablastic
Lymphoma. He was planned six cycles of CHOP regime. On follow up the residual disease was
managed with second line of chemotherapy (DHAP regimen). The patient was started on
Metronomic chemotherapy (Chlorambucil & Etoposide) in view of persistent residual disease.
Conclusion: Optimal treatment for rectal lymphoma needs to be established.
Adding Mobile Elements to Online Physical Activity Interventions Targeted at Adults Aged 50 Years and Older: Protocol for a Systematic Design
Authors: Collombon Eline H G M , Bolman Catherine A W , Peels Denise A , de Bruijn Gert-Jan , de Groot Renate H M , Lechner Lilian 
Published: March 2022

Background
Physical activity (PA) can increase mental and physical health in adults aged 50 years and older. However, it has been shown that PA guidelines are often not met within this population. Therefore, our research group developed 2 computer-tailored intervention programs in the last decade to stimulate PA: Active Plus and I Move. Although these programs were proven effective, positive effects diminished over time and attrition rates were relatively high. To respond to this, we will integrate 3 interactive mobile elements into the existing programs: activity tracker, ecological momentary intervention program, and virtual coach app.

Objective
The goal of the research is to define systematic and evidence-based steps for extending our online computer-based PA intervention programs with 3 interactive mobile elements.

Methods
Components often included in other (eHealth) design models were identified as key components and served as a base for the definition of systematic steps: exploration of context, involvement of the target population, prototype and intervention testing, and implementation. Based on these key components, 10 systematic steps were defined. The initial step is a literature search, with the results serving as a base for development of the low-fidelity prototypes in step 2. The pilot phase comprises the 3rd to 6th steps and includes semistructured interviews, pilot tests, and adaptations of the prototypes with intensive involvement of the target population of adults aged 50 years and older, where particular attention will be paid to lower educated persons. The 7th step is an effect evaluation in the form of a randomized controlled trial. During the 8th step, the most effective intervention programs will be selected and reinforced. These reinforced intervention programs will be used during the design of an implementation plan in the 9th step and the subsequent field study in the 10th step.

Results
The project will be executed from December 2019 to December 2023. During this period, the systematic approach presented will be practically executed according to the methodological procedures described.

Conclusions
Based on the 4 identified key components, we were able to design an evidence-based systematic design approach for separately adding 3 mobile elements to our existing online PA intervention programs. The 10 steps are presented as a useful approach to guide future eHealth design studies.

International Registered Report Identifier (IRRID)
DERR1-10.2196/31677
Safety of Triage Self-assessment Using a Symptom Assessment App for Walk-in Patients in the Emergency Care Setting: Observational Prospective Cross-sectional Study
Authors: Cotte Fabienne , Mueller Tobias , Gilbert Stephen , Blümke Bibiana , Multmeier Jan , Hirsch Martin Christian , Wicks Paul , Wolanski Joseph , Tutschkow Darja , Schade Brittinger Carmen , Timmermann Lars , Jerrentrup Andreas 
Published: March 2022

Background
Increasing use of emergency departments (EDs) by patients with low urgency, combined with limited availability of medical staff, results in extended waiting times and delayed care. Technological approaches could possibly increase efficiency by providing urgency advice and symptom assessments.

Objective
The purpose of this study is to evaluate the safety of urgency advice provided by a symptom assessment app, Ada, in an ED.

Methods
The study was conducted at the interdisciplinary ED of Marburg University Hospital, with data collection performed between August 2019 and March 2020. This study had a single-center cross-sectional prospective observational design and included 378 patients. The app’s urgency recommendation was compared with an established triage concept (Manchester Triage System [MTS]), including patients from the lower 3 MTS categories only. For all patients who were undertriaged, an expert physician panel assessed the case to detect potential avoidable hazardous situations (AHSs).

Results
Of 378 participants, 344 (91%) were triaged the same or more conservatively and 34 (8.9%) were undertriaged by the app. Of the 378 patients, 14 (3.7%) had received safe advice determined by the expert panel and 20 (5.3%) were considered to be potential AHS. Therefore, the assessment could be considered safe in 94.7% (358/378) of the patients when compared with the MTS assessment. From the 3 lowest MTS categories, 43.4% (164/378) of patients were not considered as emergency cases by the app, but could have been safely treated by a general practitioner or would not have required a physician consultation at all.

Conclusions
The app provided urgency advice after patient self-triage that has a high rate of safety, a rate of undertriage, and a rate of triage with potential to be an AHS, equivalent to telephone triage by health care professionals while still being more conservative than direct ED triage. A large proportion of patients in the ED were not considered as emergency cases, which could possibly relieve ED burden if used at home. Further research should be conducted in the at-home setting to evaluate this hypothesis.

Trial Registration
German Clinical Trial Registration DRKS00024909; https://www.drks.de/drks_web/navigate.do? navigationId=trial.HTML&TRIAL_ID=DRKS00024909
Self-reliance, Social Norms, and Self-stigma as Barriers to Psychosocial Help-Seeking Among Rural Cancer Survivors With Cancer-Related Distress: Qualitative Interview Study
Authors: DeGuzman Pamela Baker , Vogel David L , Bernacchi Veronica , Scudder Margaret A , Jameson Mark J 
Published: March 2022

Background
Even when technology allows rural cancer survivors to connect with supportive care providers from a distance, uptake of psychosocial referrals is low. Fewer than one-third of participants in a telemedicine intervention for identifying rural survivors with high distress and connecting them with care accepted psychosocial referral.

Objective
The purpose of this research was to examine the reasons for which rural cancer survivors did not accept a psychosocial referral.

Methods
We utilized a qualitative design to address the research purpose. We interviewed participants who had been offered psychosocial referral. Semistructured interviews were conducted 6 weeks later (n=14), and structured interviews were conducted 9 months later (n=6). Data were analyzed descriptively using an inductive approach.

Results
Ultimately, none of the rural cancer survivors (0/14, 0%) engaged with a psychosocial care provider, including those who had originally accepted referrals (0/4, 0%) for further psychosocial care. When explaining their decisions, survivors minimized their distress, emphasizing their self-reliance and the need to handle distress on their own. They expressed a preference for dealing with distress via informal support networks, which was often limited to close family members. No survivors endorsed public stigma as a barrier to accepting psychosocial help, but several suggested that self-stigma associated with not being able to handle their own distress was a reason for not seeking care.

Conclusions
Rural cancer survivors’ willingness to accept a psychosocial referral may be mediated by the rural cultural norm of self-reliance and by self-stigma. Interventions to address referral uptake may benefit from further illumination of these relationships as well as a strength-based approach that emphasizes positive aspects of the rural community and individual self-affirmation.
First Report of Phytopythium vexans (de Barry) Abad, de Cock, Bala, Robideau, Lodhi & Lévesque Causing Potato Tuber Rot in Indonesia
Authors: Santika Islaminati Anna , Widiastuti Ani , Wibowo Arif 
Published: March 2022

Phytopythium vexans (de Barry) Abad, de Cock, Bala, Robideau, Lodhi & Lévesque was successfully isolated from the soil of the potatoes field in Ngablak, Magelang. This research aimed to obtain the knowledge and potency of P. vexans as a pathogen in potatoes, identify the morphology and molecular of P. vexans compared with the Oomycetes, Phytophthora and Pythium. The morphological observation was conducted based on a macroscopic colony pattern that grew for five days on the PDA medium and microscopic observation on its hyphae, sporangia, papillate, and chlamydospore. The molecular identification was conducted using multigene analysis, ITS and LSU. The in vitro pathogenicity test was obtained by inoculating P. vexans inoculum to the healthy potatoes leaves and tubers. The results of morphological observation showed that P. vexans had a stellate pattern, aseptate hyphae, and sporangium with an ovoid shape completed with semipapillate. Chlamydospore as a survival form was also found. This research revealed that the morphology of P. vexans was between Pythium and Phytophthora. Whereas, based on the molecular analysis using ITS and LSU, the Phytopythium spp. are more closely related to Phytophthora spp. rather than Pythium spp. The pathogenicity test of P. vexans showed that it could infect the flesh of potato tubers showing a brown lesions symptom
Effect of low-level laser therapy on the time needed for leveling and alignment of mandibular anterior crowding:
Authors: Ghaffar Yasmine Khaled Abdel , El Sharaby Fouad A. , Negm Ibrahim Mazen 
Published: March 2022

ABSTRACT

Objectives
To assess the effect of low-level laser therapy (LLLT) on overall leveling and alignment time of mandibular anterior crowding and associated pain after initial archwire placement.

Materials and Methods
Thirty-two females (18-25 years) with mandibular anterior crowding were randomly allocated into laser and control groups. Eligibility criteria included Angle Class I molar relationship and Little's irregularity index (LII) from 4 to 10 mm. Randomization was accomplished with a computer-generated random list. A 0.014-inch copper-nickel-titanium (Cu-NiTi) wire was inserted immediately after bonding of 0.022-inch Roth brackets followed by 0.016-inch Cu-NiTi, 0.016 × 0.022-inch NiTi then 0.017 × 0.025-inch stainless steel wire after completion of alignment. In-Ga-As laser was applied to the mandibular anterior segment in the laser group on days 3, 7, and 14, then at 1 month followed by every 2 weeks until completion of leveling and alignment. Visual analogue scale questionnaires were completed by each patient over 7 days from initial archwire placement. Digital models were used to monitor changes in the irregularity index. Blinding was applicable for outcome assessors only.

Results
The mean time for leveling and alignment was significantly lower in the laser compared to the control group (68.2 ± 28.7 and 109.5 ± 34.7 days, respectively). The laser group displayed a significantly higher mean alignment improvement percentage as well as lower pain scores compared to the control group.

Conclusions
Within the constraints of the current study, LLLT has a potential for acceleration of anterior segment alignment as well as reduction of the pain associated with placement of initial archwires.