bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental Inequality in the American Mind: The Problem of Color-Blind Environmental Racism
Authors: Bugden Dylan 
Published: January 2022

Abstract
Despite research showing that public beliefs about the distribution of resources in society is a crucial factor in the reproduction of inequality, we do not know what Americans believe about environmental inequality or what factors structure those beliefs. Results of a novel national survey (n = 1000) show that Americans poorly understand environmental inequality, often view inequalities as fair, and are only marginally supportive of a range of key policy tools. Regression analyses reveal that the dominant factor explaining Americans’ views of environmental inequality is what I term color-blind environmental racism. Color-blind environmental racism refers to a specific manifestation of color-blind racial ideology, wherein belief in a post-racial society obfuscates and justifies environmental racism and reduces support for policy solutions. Given the pervasiveness of color-blind environmental racism in the American mind, it is likely a substantial cultural barrier facing the environmental justice movement, from local siting disputes to the passage of federal policy. Future research should build on this study to further explore the roles of public opinion and color-blind environmental racism as barriers to achieving environmental justice.
Three is Company, Four is a Crowd? Perceptions of Cultural Diversity in the Workplace
Authors: ORSINI Philippe , MAGNIER-WATANABE Remy 
Published: January 2022

AbstractCultural diversity has gained increased validation as a source of greater performance in the context of globalization. This paper examines whether there is an optimum number of foreign coworkers in order to maximize the perceived benefits and minimize the perceived threats of cultural diversity at work. Using a questionnaire survey of 572 Japanese, we found that for perceived benefits of cultural diversity at work, there is no difference between having zero or a token foreign coworker, while more foreign coworkers are associated with moderately higher perceived benefits. For perceived threats, there is a U-shaped relationship whereby interacting with zero or more than three foreign coworkers is linked to higher perceived threats compared to that of only a few foreign coworkers. Our findings reveal that in the Japanese context, interacting with about three foreign coworkers can maximize the perceived benefits while minimizing the perceived threats of cultural diversity in the workplace. Considering diversity in absolute rather than relative terms is an important contribution and implication for business and policy, as Japan and Japanese firms are increasingly dependent on globalization.
Ten-Eleven Translocation Ablation Impairs Cardiac Differentiation of Mouse Embryonic Stem Cells
Authors: Fang Shaohai , Cui Dan , Hong Tingting , Guo Lei , Lee Yi-Tsang , Lee Minjung , Isgandarova Sevinj , Martinez-Moczygemba Margarita , Zhou Yubin , Li Jia , Huang Yun 
Published: January 2022

Abstract
Ten-eleven Translocation (TET) dioxygenases mediated DNA methylation oxidation plays an important role in regulating the embryonic stem cells (ESCs) differentiation. Herein, we utilized a CRISPR/Cas9 based genome editing method to generate single, double, and triple Tet-deficient mouse ESCs (mESCs) and differentiated these cells toward cardiac progenitors. By using emerald green fluorescent protein (GFP; emGFP) expression under the control of Nkx2.5 promoter as marker for cardiac progenitor cells, we discovered that Tet1 and Tet2 depletion significantly impaired mESC-to-cardiac progenitor differentiation. Single-cell RNA-seq analysis further revealed that Tet deletion resulted in the accumulation of mesoderm progenitors to hamper cardiac differentiation. Re-expression of the Tet1 catalytic domain (Tet1CD) rescued the differentiation defect in Tet-triple knockout mESCs. Dead Cas9 (dCas9)-Tet1CD mediated loci-specific epigenome editing at the Hand1 loci validated the direct involvement of Tet-mediated epigenetic modifications in transcriptional regulation during cardiac differentiation. Our study establishes that Tet-mediated epigenetic remodeling is essential for maintaining proper transcriptional outputs to safeguard mESC-to-cardiac progenitor differentiation.
Evaluation of Black Soldier Fly larvae (Hermetia illucens) as a protein supplement for beef steers consuming low-quality forage
Authors: Fukuda Emma P , Cox Jodi R , Wickersham Tryon A , Drewery Merritt L 
Published: January 2022

Abstract
Black Soldier Fly larvae (BSFL; Hermetia illucens) has been the focus of recent feeding trials in poultry, swine, and fish; however, in vivo research has not yet been conducted in cattle. Accordingly, a study was conducted to evaluate the effects of BSFL as a protein supplement in beef steers. Six steers (603 ± 20 kg of BW, n = 3 and 404 ± 17 kg of BW, n = 3) consuming King Ranch bluestem hay (6.55% dry matter [DM] crude protein [CP]) ad libitum were used in two simultaneous 3 × 3 Latin squares. Steers were provided one of three treatments each period: 1) a control with no supplement (CON), 2) a supplement comprised of conventional feed ingredients with whole cottonseed and soybean meal as the main protein sources (CONV), and 3) a supplement with BSFL as the main protein source (BSFL). Three 14-d periods were conducted with 8 d to adapt to treatments, 5 d to measure intake and digestion, and 1 d to complete a ruminal fermentation profile. DM, organic matter (OM), CP, neutral detergent fiber (NDF), and acid detergent insoluble ash were determined in forage, supplement, ort, and fecal samples. Protein supplementation as CONV or BSFL stimulated forage OM intake (P ≤ 0.01) relative to CON with a trend for a difference (P = 0.08) between the supplements such that CONV steers consumed more FOMI than BSFL steers. Treatment affected total digestible OM intake (TDOMI; P ≤ 0.01); TDOMI for CON steers was 47.5 g/kg metabolic body weight (MBW) which was significantly less (P ≤ 0.01) than that of CONV or BSFL steers. Steers supplemented with CONV consumed significantly more TDOMI than BSFL steers (P = 0.05; 62.2 vs. 60.1 g/kg MBW, respectively). Treatment did not significantly affect digestibility of DM, OM, or NDF (P &gt; 0.32). There was also not a significant effect (P ≥ 0.17) of treatment on ruminal ammonia-N, total volatile fatty acids, or ruminal pH. Overall, these data indicate that BSFL may be an effective protein supplement for beef cattle consuming low-quality forage.
Environmental Exposure to Brominated Flame Retardants: Unraveling Endocrine and Mammary Gland Effects That May Increase Disease Risk
Authors: Gouesse Rita-Josiane , Plante Isabelle 
Published: January 2022

Abstract
Brominated flame retardants (BFR) are molecules added to consumer products to reduce fire hazards. They were banned in North America and Europe because of their persistence and biomagnification. However, BFR are still released in the environment due to continued use of products manufactured before restriction, and from waste and recycling processes of those products. As a result, they remain sources of chronic environmental and human exposure worldwide. BFR are well-characterized endocrine disruptors. They have been associated with a wide range of alterations in endocrine and reproductive systems both in humans and experimental models in vivo and in vitro. Paradoxically, the effects of BFR on mammary glands, whose development and carcinogenesis are mainly under hormonal dependency are poorly known. There is increasing weight of evidence that exposure to endocrine disruptors promotes breast cancer, especially if the exposure occurs during sensitivity windows. For the mammary gland, these windows include the perinatal life, puberty, and pregnancy, as important remodeling of the organ happens during those periods. The peak of exposure to BFRs happened during late 1990s and beginning of 2000s in most countries. Women who were pregnant at that time are reaching menopause while their daughters are 20–30 years old. It is thus important to better understand the effects of BFRs on mammary gland development and breast cancer to determine whether these women are more at risk. Thus, this review aims to propose a comprehensive review of data reporting the effects of exposure to BFR on female endocrine and reproductive systems, with a particular focus on mammary gland development and of a potential increased risk of breast cancer.
Diagnosis of Malnutrition in Children and Adolescents with Identified Developmental Disabilities (IDD) Using Subjective Global Nutrition Assessment (SGNA)
Authors: Ong Shu Hwa , Chen Seong Ting 
Published: January 2022

Abstract

Background
Children with identified developmental disabilities (IDD) experience a higher risk of growth retardation. Anthropometric indicator is one common objective measurement used to determine malnutrition in those children. A comprehensive nutritional assessment tool should be introduced to offer a more robust approach in understanding their nutritional problems.

Objective
To determine the use of Subjective Global Nutrition Assessment (SGNA) as a nutrition assessment tool for children with IDD in comparison to the anthropometric indicators.

Methods
This cross-sectional study was conducted in local community settings. IDD included in this study were autism spectrum disorder (ASD), Down syndrome (DS) and cerebral palsy (CP). SGNA and anthropometry measurements including weight, height, mid-upper arm circumference and triceps skinfolds were performed on 93 children with IDD (40 ASD, 26 DS and 27 CP) aged 5–18 years. Cohen’s Kappa, sensitivity, specificity and its 95% confidence interval were calculated between SGNA and anthropometric indicators for the agreement in determining malnutrition status of the children.

Results
SGNA identified a lower prevalence of malnutrition in children with IDD in comparison to the use of anthropometric indicators. SGNA obtained a moderate-to-fair agreement (above 80% agreement, except height-for-age parameter) and sensitivity (25.71–59.09%) against the use of a single anthropometric indicator in identifying the malnutrition status of the children.

Conclusions
The use of SGNA as an adjunct to body mass index-for-age as an anthropometric measurement for diagnosing malnutrition in children and adolescents with IDD is recommended.
Silent circulation of Zika and dengue virus in Aedes aegypti (Diptera: Culicidae) during a non-epidemic year in the state of Sergipe, northeastern Brazil
Authors: Jesus Myrela C S , Chagas Rynat D O , Santos Matheus L J , Santos Rafaela W F , La Corte Roseli , Storti-Melo Luciane M 
Published: January 2022

Abstract

Background
Dengue virus (DENV) and Zika virus (ZIKV) have a severe impact on human health worldwide. To understand the dynamics of these viruses in mosquito populations, it is necessary to maintain surveillance during non-epidemic years.

Methods
We aimed to assess the presence of DENV and ZIKV in Aedes aegypti females in the state of Sergipe, northeastern Brazil, during a non-epidemic year. The Ae. aegypti females collected were sectioned, and the heads and thorax were used to analyze the infection rate. Each female was first analyzed to detect Flavivirus using RT-PCR. Flavivirus-positive samples were further screened to detect ZIKV and DENV types 1, 2, 3 and 4.

Results
A total of 184 females were collected. ZIKV was identified in 5.4% of the sample and DENV in 7.1%, with the DENV-positive samples belonging to subtypes 2, 3 and 4. The presence of coinfected vectors was also observed. Of the four cities tested, only one was negative for all viruses.

Conclusions
These results show that the maintenance of vigilance during non-epidemic years can provide data on viruses circulating before the onset of outbreaks. This can enable the planning and implementation of local control measures to prevent the appearance of new outbreaks.
Supervisor Age and Embeddedness, Employee Embeddedness, and Job Performance
Authors: Ng Thomas W H , Koopmann Jaclyn , Lucianetti Lorenzo 
Published: January 2022

AbstractGuided by social information processing theory and regulatory focus theory, this study examines embeddedness contagion related to supervisors’ age. Older (vs. younger) supervisors are more likely to become embedded in their organizations, and when employees see these older supervisors as more embedded, they are likely to take this as a positive cue signaling them to become embedded in the organization, too. This tendency is an important topic within employee age research because it can strengthen employees’ regulatory focus, which in turn affects their job performance. Analysis of matched data collected from 406 employees and their supervisors showed that supervisors’ age was positively related to supervisors’ perceptions of their own organizational embeddedness, which then positively affected employees’ perceptions of supervisors’ and their own embeddedness. Employee embeddedness perceptions, in turn, were positively related to their promotion and prevention focus. Crucially, promotion focus, but not prevention focus, predicted a variety of performance outcomes. Thus, this study explains why employees are more likely to become organizationally embedded in the presence of older supervisors and shows that such embeddedness contagion enhances their work productivity.
Shedding light on species boundaries in small endogeic animals through an integrative approach: species delimitation in the centipedeClinopodes carinthiacus(Chilopoda: Geophilidae) in the south-eastern Alps
Authors: Peretti Emiliano , Cecchin Chiara , Fusco Giuseppe , Gregnanin Luca , Kos Ivan , Bonato Lucio 
Published: January 2022

AbstractThe investigation of species boundaries in strictly endogeic animals is challenging because they are prone to fine-scale genetic and phenotypic geographical differentiation owing to low dispersal ability. An integrative approach exploiting different sources of information has seldom been adopted in these animals and even more rarely by treating all data sources equally. We investigated species boundaries in the endogeic centipede Clinopodes carinthiacus across the south-eastern Alps by studying genetic and morphological differentiation in a sample of 66 specimens from 27 sites, complemented by the morphological examination of more than 1100 specimens from other sites. Hypotheses of species delimitation were obtained independently from the molecular sequences of three markers (mitochondrial 16S and COI and nuclear 28S) by means of different species discovery methods (automatic barcode gap discovery, assemble species by automatic partitioning, general mixed Yule coalescent and the Poisson tree process) and from ten morphological characters by means of a model-based cluster analysis and Bayesian model selection. We found strong support for the existence of at least two species: C. carinthiacus s.s. and Clinopodes strasseri, which was formerly described as a subspecies of another species, and later placed in synonymy with C. carinthiacus. The two species coexist in syntopy in at least one site.
How E-cigarettes and vaping can affect asthma in children and adolescents
Authors: Di Cicco Maria , Sepich Margherita , Beni Alessandra , Comberiati Pasquale , Peroni Diego G. 
Published: January 2022

Purpose of review
Electronic nicotine delivery systems such as e-cigarettes are commonly felt to be harmless devices when compared to traditional cigarettes. However, an increasing number of studies support the biological plausibility for the potential detrimental effects of vaping on the respiratory mucosa. To date, few human studies have been carried out on adult vapers showing a reduction in lung function testing, especially in those with asthma, whereas the effects of vaping on children and adolescents have not been elucidated so far.

Recent findings
Several cross-sectional, national, population-based studies on large groups of adolescents have been carried out showing an association between vape exposure and self-reported asthma diagnosis and/or respiratory symptoms in this age group. The effects of second and third-hand exposure together with those of active and passive exposure in pregnancy, are almost completely unknown.

Summary
This review outlines recent data on the potential effects of vaping on asthma, focusing on vape composition, reported effects on the respiratory mucosa, available data in adolescents, and reasons behind the current vaping epidemic. The evidence so far available both in animals and humans suggests that vaping is not harmless, and its exposure should be limited in children and adolescents, especially when affected by asthma.
Advances in hemorrhage control resuscitation
Authors: Muldowney Maeve , Aichholz Pudkrong , Nathwani Rajen , Stansbury Lynn G. , Hess John R. , Vavilala Monica S. 
Published: January 2022

Purpose of review
Despite significant advances in trauma management over the last twenty years, uncontrolled hemorrhage remains the leading cause of preventable death in trauma. We review recent changes affecting hemorrhage control resuscitation.

Recent findings
Early blood product usage has become well established as a standard of care in trauma hemorrhage control. To enable this, low titer group A liquid plasma and group O whole blood are increasingly utilized. Single donor apheresis platelets have now replaced pooled donor platelets in the USA and are often pathogen reduced, which has implications for trauma resuscitation. Further work is examining timing and dosing of tranexamic acid and the debate in factor concentrate usage in trauma induced coagulopathy continues to evolve. The ‘Stop the bleed’ campaign has highlighted how important the use of hemostatic dressings are in hemorrhage control, as too is the expanded use of endovascular aortic occlusion. We highlight the ongoing research into desmopressin use and the undetermined significance of ionized calcium levels in trauma. Finally, we discuss our own hospital experience with coagulation testing and the paucity of evidence of improved outcomes with viscoelastic testing.

Summary
Improving trauma coagulopathy diagnostics and hemorrhage control are vital if we are to decrease the mortality associated with trauma.
In Vitro Fertilization and Early Pregnancy Outcomes After Coronavirus Disease 2019 (COVID-19) Vaccination
Authors: Aharon Devora , Lederman Matthew , Ghofranian Atoosa , Hernandez-Nieto Carlos , Canon Chelsea , Hanley William , Gounko Dmitry , Lee Joseph A. , Stein Daniel , Buyuk Erkan , Copperman Alan B. 
Published: January 2022

OBJECTIVE:
To assess whether coronavirus disease 2019 (COVID-19) mRNA vaccination is associated with controlled ovarian hyperstimulation or early pregnancy outcomes.

METHODS:
This retrospective cohort study included patients who underwent controlled ovarian hyperstimulation or single euploid frozen-thawed embryo transfer at a single academic center. Patients fully vaccinated with a COVID-19 mRNA vaccine were compared with unvaccinated patients who cycled during the same time period. The primary outcome was the fertilization rate for controlled ovarian hyperstimulation and the clinical pregnancy rate for frozen-thawed embryo transfer. Secondary outcomes for controlled ovarian hyperstimulation included eggs retrieved, mature oocytes retrieved, mature oocytes ratio, blastulation rate, and euploid rate. Secondary outcomes for frozen-thawed embryo transfer included pregnancy rate, ongoing pregnancy rate, biochemical pregnancy loss rate, and clinical pregnancy loss rate.

RESULTS:
Among 222 vaccinated patients and 983 unvaccinated patients who underwent controlled ovarian hyperstimulation cycles between February and September 2021, there was no association on adjusted analysis between COVID-19 vaccination and fertilization rate (β=0.02±0.02, P=.20) or any of the secondary outcomes assessed: eggs retrieved (β=0.01±0.57, P=.99), mature oocytes retrieved (β=0.26±0.47, P=.58), mature oocytes ratio (β=0.02±0.01, P=.12), blastulation rate (β=0.02±0.02, P=.27), or euploid rate (β=0.05±0.03, P=.08). Among 214 vaccinated patients and 733 unvaccinated patients undergoing single euploid frozen-thawed embryo transfer, adjusted analysis demonstrated no significant association between vaccination and clinical pregnancy (adjusted odds ratio [aOR] 0.79, 95% CI 0.54–1.16) or any of the secondary outcomes: pregnancy (aOR 0.88, 95% CI 0.58–1.33), ongoing pregnancy (aOR 0.90, 95% CI 0.61–1.31), biochemical pregnancy loss (aOR 1.21, 95% CI 0.69–2.14), or clinical pregnancy loss (aOR 1.02, 95% CI 0.51–2.06).

CONCLUSION:
Administration of COVID-19 mRNA vaccines was not associated with an adverse effect on stimulation or early pregnancy outcomes after IVF. Our findings contribute to the growing body of evidence regarding the safety of COVID-19 vaccination in women who are trying to conceive.
Effects of Whole Pelvic Radiotherapy on the Distribution of Lymphocyte Subpopulations in Prostate Cancer Patients
Authors: Roviello Giandomenico , Nardone Valerio , Bonetta Alberto , Correale Pierpaolo , Molteni Alfredo , Lazzari Maria C. , Generali Daniele 
Published: January 2022

Introduction:
In the current study, we have investigated the effects of the different modalities of treatment (volume of radiotherapy [RT], previous surgery) as well as the Gleason score of prostate cancer (PC) on the lymphocyte composition of PC patients undergoing RT.

Methods:
This is a monoinstitutional study that prospectively included PC patients that underwent RT from January 2016 until December 2017. To compare the different evaluations, the Wilcoxon signed-rank test was used among 2 times (Timepoint 0 to Timepoint 1). Percentage variation was calculated for all the lymphocyte subpopulation and was correlated with clinical parameters (previous surgery, Gleason score, and pelvic irradiation) with the χ2 test. The statistical analysis was repeated also on the stratified dataset according to the above parameters (previous surgery, Gleason score, and whole pelvic radiotherapy [WPRT]).

Results:
One hundred and eleven patients were included in the present analysis. All the lymphocyte subpopulations resulted significantly lower after RT. The modifications of several lymphocyte subpopulations correlated with previous surgery, Gleason score, and WPRT, although stratified analysis demonstrated that WPRT showed the greatest correlation.

Conclusion:
Our results could be used to design a prospective trial in order to study the use of WPRT on the lymphocyte subpopulations.
The Role of Plastic Surgery in the Treatment of Recurrent and Large Penile Keloid
Authors: Alzeerelhouseini Hussam I.A. , Alzaro Rashad M. 
Published: January 2022

Summary:
Penile keloid is an extremely rare condition that most commonly occurs as a complication of circumcision. In this article, we describe a unique case of recurrent, large penile keloid formation after circumcision in an 11-year-old White boy. This was treated by surgical excision and reconstruction of penile shaft by skin graft followed by serial intradermal steroid injections. A good aesthetic outcome was achieved with no keloid recurrence during a 1-year follow-up. In addition, we extensively reviewed all available literature studies of penile keloid from 1966 to 2021 with their treatments and outcomes. We summarized all reported cases and presented them in a comprehensive table.