bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare case of a retrocrural lymph node metastasis from a chromophobe renal cell cancer: complete thoracoscopic resection with a new multi-joint articulating surgical instrument
Authors: Kern Alexander , Thomas Christian , Holotiuk Olaf , Drewes Steffen 
Published: July 2022

Abstract
We report a rare case of a 69-year-old man with a solitary retrocrural lymph node metastasis in the posterior mediastinum of an oligo-metastatic chromophobe renal cell cancer that was radically resected in a curative intent using new articulating Artisential® instruments.
Sustainability and textile ideas implementation
Authors: Al-Qahtani Laila Amer , Al-Jumaily Ahmed 
Published: July 2022

AbstractThe textile industries in the Kingdom of Saudi Arabia are considered one of the important industries in which the produced parts are linked to the consumer who may choose them later to buy them. The culture of preserving fabric sustainability in the living room is not intended to retain the history of fabric. Therefore, it was necessary to think of more sustainable ways of implementing and manufacturing textiles by involving consumers in the manufacturing processes. The production of textile pieces in a way that meets his needs and fulfills his own desires and inclinations is the reason for creating that link between them, which makes him aware of the importance of each piece and thus the necessity of preserving it and striving for its sustainability by creating that sense of responsibility towards it. Among them, the aim of the research was to search for the most important different methods of implementing textile manufacturing in internal spaces and highlighting them through a comparison of five different methods. The research followed the analytical and comparative methodology, whereby each method was studied separately and analysed, then a comparison was made between the five different methods. After that, a set of important points were drawn up in the form of research recommendations in the process of sustaining industrial implementation.
Heuristic power flow optimization of hybrid power systems integrated with bulk renewable energy sources and battery storage
Authors: Laly M J , Cheriyan Elizabeth P , Sunitha R , Alhelou Hassan Haes 
Published: July 2022

Abstract
The integration of various types of renewable energy sources and storage systems into power system increases the complexity of the conventional power system, necessitating a comprehensive optimal power flow (OPF) analysis with multiple and/or competing objectives. From this viewpoint, the paper proposes optimal utilization of different power system entities, by solving the OPF problem using the heuristic particle swarm optimization technique. The proposed methodology optimizes the power flow of a complex, nonlinear hybrid power system to fulfill several objectives, viz., line loss minimization, cost minimization and profit maximization under varying environmental conditions and system attributes. A modified IEEE system replacing conventional sources with renewables and storage system is considered for study. Results corroborate the effectiveness of the strategy.
In Utero Activation of Natural Killer Cells in Congenital Cytomegalovirus Infection
Authors: Vaaben Anna V , Levan Justine , Nguyen Catherine B T , Callaway Perri C , Prahl Mary , Warrier Lakshmi , Nankya Felistas , Musinguzi Kenneth , Kakuru Abel , Muhindo Mary K , Dorsey Grant , Kamya Moses R , Feeney Margaret E 
Published: July 2022

AbstractBackgroundCongenital cytomegalovirus (CMV) infection is the most common infectious cause of birth defects and neurological damage in newborns. Despite a well-established role for natural killer (NK) cells in control of CMV infection in older children and adults, it remains unknown whether fetal NK cells can sense and respond to CMV infection acquired in utero.MethodsHere, we investigate the impact of congenital CMV infection on the neonatal NK-cell repertoire by assessing the frequency, phenotype, and functional profile of NK cells in cord blood samples from newborns with congenital CMV and from uninfected controls enrolled in a birth cohort of Ugandan mothers and infants.ResultsWe find that neonatal NK cells from congenitally CMV infected newborns show increased expression of cytotoxic mediators, signs of maturation and activation, and an expansion of mature CD56− NK cells, an NK-cell subset associated with chronic viral infections in adults. Activation was particularly prominent in NK cell subsets expressing the Fcγ receptor CD16, indicating a role for antibody-mediated immunity against CMV in utero.ConclusionsThese findings demonstrate that NK cells can be activated in utero and suggest that NK cells may be an important component of the fetal and infant immune response against CMV.Clinical Trials RegistrationNCT02793622.
21st Century Cures Act: ethical recommendations for new patient-facing products
Authors: Durieux Brigitte N , DeCamp Matthew , Lindvall Charlotta 
Published: July 2022

Abstract

Background
Recent legislation ensuring patient access to their electronic health records represents a promising national commitment to patient empowerment. Access and interoperability rules seek to empower individuals as well as increase opportunities for data sharing by hospitals, apps, and other parties for research and innovation. However, there are trade-offs between data accessibility and oversight. Some third-party apps may not be covered by federal regulations, and receiving records directly from individuals may render some services in possession of health data. To promote consumer trust, these services should follow ethical standards regardless of regulatory status.

Actionable Principles
This Perspective proposes 3 actionable principles, grounded in medical ethics, for services making use of health data: services should (1) provide informed, dynamic, regular consent, including control over data sharing, (2) promote inclusivity and equity, and (3) intentionally focus on consumer trust and the perception of value in the service provided.
Study on HPLC Fingerprint, Network Pharmacology, and Antifungal Activity of Rumex japonicus Houtt
Authors: Xiao Dandan , Wang Juntong , Zhong Yuan , Sun He , Wang Mengtong , Wang Xueyu , Ding Yuling , Li Yong , Wang Ye 
Published: July 2022

Abstract

Background
Rumex japonicus Houtt (R. japonicus) is used mainly to treat various skin diseases in Southeast Asia. However, there are few studies on its quality evaluation methods and antifungal activity.

Objective
To establish the quality control criteria for the effective parts from R. japonicus against psoriasis.

Methods
High-performance liquid chromatography (HPLC) was established for its fingerprint, and the similarity evaluation, cluster analysis (CA) and principal component analysis (PCA) were used to reveal the differences of those fingerprints among the tested R. japonicus. Network pharmacology analyzed the relationship between the components and psoriasis, revealing the potential targets of R. japonicus. Oxford cup anti-C. albicans experiment was used to verify the antifungal activity of R. japonicus.

Results
HPLC was developed for the R. japonicus fingerprint by optimizing for 10 batches of quinquennial R. japonicus from different habitats; the 18 common peaks were identified with 10 characteristic peaks such as rutin, quercetin, aloe-emodin, nepodin, emodin, musizin-8-O-β-D-glucoside, chrysophanol, emodin-8-O-β-D-glucopyranoside, chrysophanol-8-O-β-D-glucopyranoside, and aloin, respectively. The network pharmacology-based analysis showed a high correlation between R. japonicus and psoriasis, revealing the potential targets of R. japonicus. The oxford cup anti-Candida albicans experiment displayed a significant activity response to emodin-8-O-β-D-glucopyranoside and the ethyl acetate fraction of R. japonicus acidic aqueous extract.

Conclusions
A new and optimized HPLC method was created, and the research provides an experimental basis for the development of effective drugs related to C. albicans.

Highlights
The fingerprint of R. japonicus was organically combined with network pharmacology to further clarify its criteria for quality control.
Deep Learning vs Traditional Breast Cancer Risk Models to Support Risk-Based Mammography Screening
Authors: Lehman Constance D , Mercaldo Sarah , Lamb Leslie R , King Tari A , Ellisen Leif W , Specht Michelle , Tamimi Rulla M 
Published: July 2022

Abstract

Background
Deep learning breast cancer risk models demonstrate improved accuracy compared with traditional risk models but have not been prospectively tested. We compared the accuracy of a deep learning risk score derived from the patient’s prior mammogram to traditional risk scores to prospectively identify patients with cancer in a cohort due for screening.

Methods
We collected data on 119 139 bilateral screening mammograms in 57 617 consecutive patients screened at 5 facilities between September 18, 2017, and February 1, 2021. Patient demographics were retrieved from electronic medical records, cancer outcomes determined through regional tumor registry linkage, and comparisons made across risk models using Wilcoxon and Pearson χ2 2-sided tests. Deep learning, Tyrer-Cuzick, and National Cancer Institute Breast Cancer Risk Assessment Tool (NCI BCRAT) risk models were compared with respect to performance metrics and area under the receiver operating characteristic curves.

Results
Cancers detected per thousand patients screened were higher in patients at increased risk by the deep learning model (8.6, 95% confidence interval [CI] = 7.9 to 9.4) compared with Tyrer-Cuzick (4.4, 95% CI = 3.9 to 4.9) and NCI BCRAT (3.8, 95% CI = 3.3 to 4.3) models (P &lt; .001). Area under the receiver operating characteristic curves of the deep learning model (0.68, 95% CI = 0.66 to 0.70) was higher compared with Tyrer-Cuzick (0.57, 95% CI = 0.54 to 0.60) and NCI BCRAT (0.57, 95% CI = 0.54 to 0.60) models. Simulated screening of the top 50th percentile risk by the deep learning model captured statistically significantly more patients with cancer compared with Tyrer-Cuzick and NCI BCRAT models (P &lt; .001).

Conclusions
A deep learning model to assess breast cancer risk can support feasible and effective risk-based screening and is superior to traditional models to identify patients destined to develop cancer in large screening cohorts.
Trends in imported malaria during the COVID-19 pandemic, Spain (+Redivi Collaborative Network)
Authors: Norman Francesca F , Treviño-Maruri Begoña , Ruiz Giardín José Manuel , Gullón-Peña Beatriz , Salvador Fernando , Serre Nuria , Díaz-Menéndez Marta , Calabuig Eva , Rodriguez-Guardado Azucena , Lombide Itxaso , Pérez-Ayala Ana , Torrús Diego , Goikoetxea Josune , García-Rodriguez Magdalena , Pérez-Molina Jose A ,   for the +Redivi Study Group
Published: July 2022

Abstract

Introduction
The COVID-19 pandemic has caused disruptions in prevention and management strategies for malaria globally. Currently, data analysing trends in travel-related infections during the pandemic years are scarce. The objective of this analysis was to describe the epidemiological and clinical characteristics of patients with imported malaria within the +Redivi network in Spain, focusing on yearly trends from pre-pandemic years to date.

Methods
Cases recorded in +Redivi from October 2009 to December 2021 were analysed and patients with a diagnosis of malaria (standard diagnostic methods using thick/thin peripheral blood smears, with/without a malaria rapid diagnostic test and/or Plasmodium spp. polymerase chain reaction) were identified. The total number of malaria cases, cases according to type of patient and severe cases, per year, were analysed.

Results
In total, 1751 cases of malaria (1751/26 601, 6.6%) were identified. The majority occurred in males (1041, 59.5%), median age was 36.3 (interquartile range: 27–44.7) years and most occurred in visiting friends and relatives (VFR)-immigrants (872, 49.8%). Most infections were acquired in sub-Saharan Africa (1.660, 94.8%) and were due to Plasmodium falciparum (81.3%). There were 64 cases of severe malaria (3.7%) and 4 patients died (0.2% mortality, all in pre-pandemic years). A significant increase in cases of severe malaria was observed during the study period (P &lt; 0.001) (attributable to the increase in 2021). There were 16/93 severe cases in 2021 (17.2%), all due to Plasmodium falciparum, (compared with ≤ 5% in previous years), which mainly occurred in travellers and VFR-immigrants (10/16, 62.5% and 5/16, 31.3%, respectively).

Conclusions
After an initial decline associated with travel restrictions due to the ongoing COVID-19 pandemic, an increase in imported malaria and a significant increase in cases of severe malaria was observed. Patients with imported malaria may present and/or be diagnosed late during this public health crisis and health care professionals should be alerted to the recent increase in severe cases.
Using search engines as a retrieval tool for translating newly coined expressions and terminology between Chinese and English
Authors: Wang Zheng 
Published: July 2022

AbstractTranslating terminology and newly coined expressions is a daunting challenge for technical translators. Translation of such words or phrases between, e.g. Chinese and English has received little help from dictionaries. With this as motivation, this study explores four methods by analysing results from an experiment with search engines as a retrieval tool for tackling such translation tasks. Specifically, taking 700 new terminologies from The Oxford English Dictionary as the research objects, this study experimentally examines the four terminology translation extraction methods. For each method, the effectiveness is assessed. This article finds that template-based and dictionary-based translation extraction methods have the highest accuracy rates of 86 and 89%, respectively. The semantic prediction search method proves to be the most flexible with the highest retrieval rate of 95%, although its results are not always accurate. Based on the results, this study proposes a model for quantitatively and qualitatively verifying the accuracy of translation results obtained from search engines. The quantitative analysis examines the use frequency of all translations obtained, while the qualitative analysis looks into their contexts. These findings have implications for translating, via search engine retrieval tools, terminology between other language pairs.
The fall of CSS100217: a tidal disruption-induced low state in an apparently hostless active galactic nucleus
Authors: Cannizzaro G , Levan A J , van Velzen S , Brown G 
Published: July 2022

ABSTRACT
CSS100217 was a nuclear, rapid, and luminous flare in a narrow-line seyfert 1 galaxy, whose initial interpretation as a supernova is now debated between variability of the active galactic nucleus (AGN) and a tidal disruption event (TDE). In this paper, we present and discuss new evidence in favour of a TDE or extreme flaring episode scenario. After the decay of the flare, the galaxy entered a long-term low luminosity state, 0.4 mag lower than the pre-outburst emission in the V band. We attribute this to the creation of a cavity in the accretion disc after the tidal disruption of a star in a retrograde orbit with respect to the accretion disc rotation, making a TDE our favoured interpretation of the flare. We also show how the host galaxy shows a point-like, compact profile, no evidence for an extended component and a relatively low mass, unlike what expected from an AGN host galaxy at z = 0.147. A compact host galaxy may result in an increased TDE rate, strengthening our interpretation of the event.
Study of 2021 outburst of the recurrent nova RS Ophiuchi: Photoionization and morphokinematic modelling
Authors: Pandey Ruchi , Habtie Gesesew R , Bandyopadhyay Rahul , Das Ramkrishna , Teyssier François , Guarro Fló Joan 
Published: July 2022

ABSTRACT
We present the evolution of the optical spectra of the 2021 outburst of RS Ophiuchi (RS Oph) over about a month after the outburst. The spectral evolution is similar to the previous outbursts. Early spectra show prominent P Cygni profiles of hydrogen Balmer, Fe ii, and He i lines. The emission lines were very broad during the initial days, which later became narrower and sharper as the nova evolved. This is interpreted as the expanding shocked material into the winds of the red giant companion. We find that the nova ejecta expanded freely for ∼4 d, and afterwards, the shock velocity decreased monotonically with time as v ∝ t−0.6. The physical and chemical parameters associated with the system are derived using the photoionization code cloudy. The best-fitting cloudy model shows the presence of a hot central white dwarf source with a roughly constant luminosity of ∼1.00 × 1037 erg s−1. The best-fitting photoionization models yield absolute abundance values by number, relative to solar of He/H ∼1.4–1.9, N/H = 70–95, O/H = 0.60–2.60, and Fe/H ∼1.0–1.9 for the ejecta during the first month after the outburst. Nitrogen is found to be heavily overabundant in the ejecta. The ejected hydrogen shell mass of the system is estimated to be in the range of $3.54 - 3.83 \times 10^{-6}\, {\rm M}_{\odot }$. The 3D morphokinematic modelling shows a bipolar morphology and an inclination angle of i = 30° for the RS Oph binary system.
Multiple phase spirals suggest multiple origins in Gaia DR3
Authors: Hunt Jason A S , Price-Whelan Adrian M , Johnston Kathryn V , Darragh-Ford Elise 
Published: July 2022

ABSTRACT
Gaia Data Release 2 revealed that the Milky Way contains significant indications of departures from equilibrium in the form of asymmetric features in the phase space density of stars in the Solar neighbourhood. One such feature is the z–vz phase spiral, interpreted as the response of the disc to the influence of a perturbation perpendicular to the disc plane, which could be external (e.g. a satellite) or internal (e.g. the bar or spiral arms). In this work, we use Gaia Data Release 3 to dissect the phase spiral by dividing the local data set into groups with similar azimuthal actions, Jϕ, and conjugate angles, θϕ, which selects stars on similar orbits and at similar orbital phases, thus having experienced similar perturbations in the past. These divisions allow us to explore areas of the Galactic disc larger than the surveyed region. The separation improves the clarity of the z–vz phase spiral and exposes changes to its morphology across the different action-angle groups. In particular, we discover a transition to two armed ‘breathing spirals’ in the inner Milky Way. We conclude that the local data contain signatures of not one, but multiple perturbations with the prospect to use their distinct properties to infer the properties of the interactions that caused them.
Bell’s palsy with facial bone involvement: A rare presentation of chronic nonbacterial osteomyelitis with literature review
Authors: Ailumerab Haider A , Aguiar Cassyanne L 
Published: July 2022

ABSTRACT
Chronic nonbacterial osteomyelitis (CNO) is a chronic, sterile, inflammatory disease. It primarily presents with nonspecific bone pain and swelling but ultimately can cause bone destruction and deformities, if left untreated. The involvement of the cranial bones (apart from the mandible) is rare in CNO. In this report, we present a rare case of CNO affecting facial and cranial bones presenting as facial palsy with a review of the literature about similar affection. A 10-year-old, previously healthy female was initially evaluated for swelling of the left side of her face with slight tenderness on palpation, but no fever. Her complete blood count was unremarkable, her inflammatory markers were elevated (C-reactive protein 7.5 mg/dl and erythrocyte sedimentation rate 104 mm/h), and CT of facial and skull bones and MRI of brain showed a destructive osseous process involving the left maxillary, zygomatic, sphenoid bones and the clivus. Bone biopsy of the left maxilla showed fibrous dysplasia with abscess formation, most consistent with an infectious aetiology (acute osteomyelitis). She was started on oral clindamycin for a 3-month course. The facial swelling improved after starting clindamycin, but on her sixth week of treatment, she developed right-sided Bell’s palsy. An MRI of the brain showed hyperenhancement of the right seventh cranial nerve. A month later, she was evaluated for right wrist and knee swelling, pain, and limitation of movement. Skeletal survey and MRI showed multifocal lesions with mixed sclerosis and lucency. Her inflammatory markers continued to be elevated. Another bone biopsy of the right radius showed similar findings of destruction with no evidence of malignancy. She was ultimately diagnosed with CNO. She was started on nonsteroidal anti-inflammatory drugs with gastric protection and regular follow-up. Over more than a year of follow-up, the patient’s inflammatory markers remain normal, and joint swelling/limitation has remained in remission. We found five additional cases in the literature that presented with a similar presentation. To our knowledge, our patient is the first reported case in the USA involving the cranial/facial bones apart from the mandible presenting with facial palsy. The affection of the facial bones (apart from the mandible) in CNO is very rare, but the awareness of such a presentation by the clinician is an important aspect of reaching the diagnosis.
Vitamin B6 based Pt(II) complexes: biomolecule derived potential cytotoxic agents for thyroid cancer
Authors: Ming Jialin , Bhatti Muhammad Zeeshan , Ali Amjad , Zhang Zeqing , Wang Na , Mohyuddin Aisha , Chen Jiwu , Zhang Yongmin , Rahman Faiz-Ur 
Published: July 2022

Abstract
Vitamin B6 is an essential vitamin that serves as a co-enzyme in a number of enzymatic reactions in metabolism of lipids, amino acids, and glucose. In the current study, we synthesized vitamin B6 derived ligand (L) and its complex Pt(L)Cl (C1). The ancillary chloride ligand of C1 was exchanged with pyridine co-ligand and another complex Pt(L)(py).BF4 (C2) was obtained. Both these complexes were obtained in excellent isolated yields and characterized thoroughly by different analytical methods. Thyroid cancer is one of the most common malignancies of the endocrine system, we studied the in vitro anticancer activity and mechanism of these vitamin B6 derived L and Pt(II) complexes in thyroid cancer cell line (FTC). Based on MTT assay, cell proliferation rate was reduced in a dose-dependent manner. According to apoptosis analysis, vitamin B6 based Pt(II) complexes treated cells depicted necrotic effect and TUNEL based apoptosis was observed in cancer cells. Furthermore, qRT-PCR analyses of cancer cells treated with C1 and/or C2 showed regulated expression of anti-apoptotic, pro-apoptosis and autophagy related genes. Western blot results demonstrated that C1 and C2 induced the activation of p53 and the cleavage of Poly (ADP-ribose) polymerase (PARP). These results suggest that these complexes inhibit the growth of FTC cells and induce apoptosis through p53 signaling. Thus, vitamin B6 derived Pt(II) complexes C1 and C2 may be potential cytotoxic agents for the treatment of thyroid cancer.