bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microstructure and long-term stability of Ni–YSZ anode supported fuel cells: a review
Authors: Vafaeenezhad Sajad , Hanifi Amir Reza , Laguna-Bercero Miguel A , Etsell Thomas H , Sarkar Partha 
Published: August 2022

Abstract
Nickel–yttria stabilized zirconia (Ni–YSZ) cermet is the most commonly used anode in solid oxide fuel cells (SOFCs). The current article provides an insight into parameters which affect cell performance and stability by reviewing and discussing the related publications in this field. Understanding the parameters which affect the microstructure of Ni–YSZ such as grain size (Leng et al 2003 J. Power Sources
117 26–34) and ratio of Ni to YSZ, volume fraction of porosity, pore size and its distribution, tortuosity factor, characteristic pathway diameter and density of triple phase boundaries is the key to designing a fuel cell which shows high electrochemical performance. Lack of stability has been the main barrier to commercialization of SOFC technology. Parameters influencing the degradation of Ni–YSZ supported SOFCs such as Ni migration inside the anode during prolonged operation are discussed. The longest Ni-supported SOFC tests reported so far are examined and the crucial role of chromium poisoning due to interconnects, stack design and operating conditions in degradation of SOFCs is highlighted. The importance of calcination and milling of YSZ to development of porous structures suitable for Ni infiltration is explained and several methods to improve the electrochemical performance and stability of Ni–YSZ anode supported SOFCs are suggested.
mBrainAligner-Web: a web server for cross-modal coherent registration of whole mouse brains
Authors: Li Yuanyuan , Wu Jun , Lu Donghuan , Xu Chao , Zheng Yefeng , Peng Hanchuan , Qu Lei 
Published: August 2022

AbstractSummaryRecent whole-brain mapping projects are collecting increasingly larger sets of high-resolution brain images using a variety of imaging, labeling and sample preparation techniques. Both mining and analysis of these data require reliable and robust cross-modal registration tools. We recently developed the mBrainAligner, a pipeline for performing cross-modal registration of the whole mouse brain. However, using this tool requires scripting or command-line skills to assemble and configure the different modules of mBrainAligner for accommodating different registration requirements and platform settings. In this application note, we present mBrainAligner-Web, a web server with a user-friendly interface that allows to configure and run mBrainAligner locally or remotely across platforms.Availability and implementationmBrainAligner-Web is available at http://mbrainaligner.ahu.edu.cn/ with source code at https://github.com/reaneyli/mBrainAligner-web.Supplementary informationSupplementary data are available at Bioinformatics online.
Financialisation as the development of fictitious capital in developing and developed economies
Authors: Mollo Maria de Lourdes Rollemberg , Dourado Fernando Fellows , Paraná Edemilson 
Published: August 2022

Abstract
In this paper, we discuss financialisation as the development of fictitious capital in more developed and less developed countries. The controversies surrounding the meaning of fictitious capital require a preliminary discussion on its conceptual definition, which is done by means of an analysis of the relationship between real and fictitious capital within the labour theory of value. Once theoretically explained why the relative autonomy of circulation from production supports financialisation as the development of fictitious capital, we focus on the limits of this relative autonomy, which is something objectified in economic crises. Relevant data were gathered to determine how the concentration of financial investments in fictitious capital in a few markets was able to underpin its enormous and lasting development, even though this fictitious capital, by definition, does not generate surplus or new (labour) value. Furthermore, the analysis of net capital flows between developed and developing countries also demonstrates that the latter are net donors of capital. Therefore, it is possible to verify the relationship between the development of fictitious capital and the increase of inequality between countries.
TopEx: topic exploration of COVID-19 corpora - Results from the BioCreative VII Challenge Track 4
Authors: Olex Amy L , French Evan , Burdette Peter , Sagiraju Srilakshmi , Neumann Thomas , Gal Tamas S , McInnes Bridget T 
Published: August 2022

Abstract

TopEx is a natural language processing application developed to facilitate the exploration of topics and key words in a set of texts through a user interface that requires no programming or natural language processing knowledge, thus enhancing the ability of nontechnical researchers to explore and analyze textual data. The underlying algorithm groups semantically similar sentences together followed by a topic analysis on each group to identify the key topics discussed in a collection of texts. Implementation is achieved via a Python library back end and a web application front end built with React and D3.js for visualizations. TopEx has been successfully used to identify themes, topics and key words in a variety of corpora, including Coronavirus disease 2019 (COVID-19) discharge summaries and tweets. Feedback from the BioCreative VII Challenge Track 4 concludes that TopEx is a useful tool for text exploration for a variety of users and tasks.

Databse URL
http://topex.cctr.vcu.edu
Stroke-induced changes to immune function and their relevance to increased risk of severe COVID-19 disease
Authors: McCulloch Laura , Mouat Isobel C , South Kieron , McColl Barry W , Allan Stuart M , Smith Craig J 
Published: August 2022

Abstract
As the COVID-19 pandemic moves towards endemic disease, it remains of key importance to identify groups of individuals vulnerable to severe infection and understand the biological factors that mediate this risk. Stroke patients are at increased risk of developing severe COVID-19, likely due to stroke-induced alterations to systemic immune function. Furthermore, immune responses associated with severe COVID-19 in patients without a history of stroke parallel many of the immune alterations induced by stroke, possibly resulting in a compounding effect that contributes to worsened disease severity. In this review, we discuss the changes to systemic immune function that likely contribute to augmented COVID-19 severity in patients with a history of stroke and the effects of COVID-19 on the immune system that may exacerbate these effects.
Transfemoral transcatheter aortic valve replacement for severe aortic stenosis with concomitant left ventricular diverticulum: a case report
Authors: Xi Siyu , Zhang Haishan , Chen Xin , Guo Liang 
Published: August 2022

Abstract

Background
Left ventricular diverticulum (LVD) is a rare cardiac malformation in patients with severe aortic stenosis (AS). Transcatheter aortic valve replacement (TAVR) is not recommended due to the risk of diverticulum injury. However, for patients considered inoperable or at high surgical risk, TAVR might be the only treatment option. The safety and feasibility of TAVR for severe AS with concomitant LVD are still unclear.

Case summary
An 80-year-old Asian woman complaining of shortness of breath was admitted to our hospital, whose echocardiogram showed calcified severe AS and a diverticulum in the left ventricular apex. A transfemoral 26 mm Venus-A prosthetic aortic valve was successfully implanted. Pre- and post-procedural cardiac magnetic resonance imaging revealed a remarkable volume reduction of LVD.

Discussion
Transfemoral TAVR was not preferred because the straight-tip hydrophilic wire and catheter tip could injure the fragile diverticulum wall. If we could avoid the injury of the diverticulum, TAVR would be a good option for patients at high surgical risk.
Evaluation of the risk factors for severe complications and surgery of intestinal foreign bodies in adults: a single-center experience with 180 cases
Authors: Hu Tingting , Zhang Jie , Liu Yang , Chen Lifang , Cen Wei , Wu Wenzhi , Huang Qingke , Sun Xuecheng , Stock Simon , Zippi Maddalena , Zimmer Vincent , Basharat Zarrin , Hong Wandong 
Published: August 2022

Abstract

Background
Foreign bodies (FBs) lodged in the intestine or causing intestinal complications are uncommon in clinical practice but may pose diagnostic difficulties and prove life-threatening. This study aimed to evaluate the risk factors for severe complications and surgery to aid clinicians in the diagnosis and management of intestinal FBs.

Methods
We performed a retrospective analysis of patients in whom FBs were lodged in the intestine or caused complications from 2010 to 2020 in the First Affiliated Hospital of Wenzhou Medical University (Zhejiang, China). The characteristics of the patients and FBs, symptoms, imaging findings, diagnostics, treatment strategies, and clinical outcomes were analysed. Furthermore, the risk factors for complications and surgery were investigated.

Results
In total, 180 patients were included in our study. Most patients (76.1%) were unable to provide a history of ingestion. Bezoars were the most common FBs (35.6%). The FBs were mainly located in the duodenum (32.8%) and the ileum (27.8%). Surgical removal of FBs was successful in 89 (49.4%) patients and endoscopic removal in 54 (30.0%) patients. Eleven with perforations were treated conservatively. FBs located in the jejunum or ileum were more likely to cause severe complications than those located in the duodenum. FBs located in the jejunum, ileum, or sigmoid colon were more likely to undergo surgery, and severe complications were an independent risk factor for surgery.

Conclusion
Intestinal FBs, often localized in angulation, are likely to be misdiagnosed because most patients do not provide a history of FB ingestion. Surgery and endoscopic therapy are the most commonly used treatment modalities. Surgery is not mandatory in clinically stable patients with small and contained perforations. FBs located in the jejunum or ileum are risk factors for both complications and surgery.
Intergenerational Social Mobility and Health in Later Life: Diagonal Reference Models Applied to the Lothian Birth Cohort 1936
Authors: Iveson Matthew H , Cox Simon R , Deary Ian J 
Published: August 2022

Abstract

Objective
Although commonly used to model associations between intergenerational social mobility and health, linear regression cannot estimate the contributions of origin, destination, and mobility independently. Nonlinear diagonal reference models (DRMs) have become a popular alternative and have been applied to various health outcomes, though few studies examine the impact of social mobility on later-life health.

Methods
This study revisits health outcomes examined in the Lothian Birth Cohort 1936, using DRMs to assess the association between intergenerational social mobility and satisfaction with life, self-rated health, depression, and mortality from age 68–82 years.

Results
After adjusting for sex, age, education, and childhood cognitive ability, there was no evidence of an association between intergenerational social mobility and later-life health; participants experiencing upward or downward mobility had similar odds of poor health outcomes as non-mobile participants. However, those from higher occupational social classes exhibited lower odds of mortality (p = .01), with a stronger contribution of adult (own) than of childhood (father’s) social class (weights = 0.75 vs. 0.25). No other outcomes demonstrated significant associations with socioeconomic position.

Discussion
This adds to evidence that social mobility does not influence variation in later-life health once other factors—including socioeconomic origins and destinations—are accounted for.
A Group Videogame-Based Physical Activity Program Improves Walking Speed in Older Adults Living With a Serious Mental Illness
Authors: Leutwyler Heather , Hubbard Erin , Cooper Bruce 
Published: August 2022

Abstract

Background and Objectives
One of the most overlooked populations in our society and in health care are middle-aged and older adults living with a serious mental illness (SMI) despite the growing numbers of this population. Health care communities, including both inpatient and outpatient mental health programs, have a responsibility to provide care that nurtures clients’ mental as well as physical health needs. Providing accessible and engaging physical activity programs is an excellent way to provide this type of holistic care. The purpose of this article is to describe the impact of a pilot videogame-based physical activity program on walking speed in older adults with SMI.

Research Design and Methods
A one-group pretest post-test pilot study was conducted with a sample of 52 older adults with SMI recruited from community-based mental health programs. Participants played an active videogame (using the Kinect for Xbox 360 game system; Microsoft, Redmond, WA) for 50-minute group sessions 3 times a week for 10 weeks. Walking speed was assessed with the timed 3-m walk from the Short Physical Performance Battery at enrollment, 5 weeks, and 10 weeks.

Results
Participants achieved statistically significant improvement in walking speed (0.10 m/s, bias-corrected confidence interval Lower Limit (LL) 0.04, Upper Limit (UL) 0.15) over a 10-week period. This change represents a clinically and statistically (p ≤ .05) significant improvement in walking speed. Best estimates for clinically meaningful changes in walking speed are 0.05 m/s for a small change and 0.10 m/s for a substantial change.

Discussion and Implications
Results suggest that engagement in a group videogame-based physical activity program has the potential to improve walking speed in older adults with SMI. In turn, walking speed is an important indicator of premature mortality and cardiorespiratory fitness.
Predicting Hospice Transitions in Dementia Caregiving Dyads: An Exploratory Machine Learning Approach
Authors: Sullivan Suzanne S , Bo Wei , Li Chin-Shang , Xu Wenyao , Chang Yu-Ping 
Published: August 2022

AbstractBackground and ObjectivesHospice programs assist people with serious illness and their caregivers with aging in place, avoiding unnecessary hospitalizations, and remaining at home through the end-of-life. While evidence is emerging of the myriad of factors influencing end-of-life care transitions among persons living with dementia, current research is primarily cross- sectional and does not account for the effect that changes over time have on hospice care uptake, access, and equity within dyads.Research Design and MethodsSecondary data analysis linking the National Health and Aging Trends Study to the National Study of Caregiving investigating important social determinants of health and quality-of-life factors of persons living with dementia and their primary caregivers (n = 117) on hospice utilization over 3 years (2015–2018). We employ cutting-edge machine learning approaches (correlation matrix analysis, principal component analysis, random forest [RF], and information gain ratio [IGR]).ResultsIGR indicators of hospice use include persons living with dementia having diabetes, a regular physician, a good memory rating, not relying on food stamps, not having chewing or swallowing problems, and whether health prevents them from enjoying life (accuracy = 0.685; sensitivity = 0.824; specificity = 0.537; area under the curve (AUC) = 0.743). RF indicates primary caregivers’ age, and the person living with dementia’s income, census division, number of days help provided by caregiver per month, and whether health prevents them from enjoying life predicts hospice use (accuracy = 0.624; sensitivity = 0.713; specificity = 0.557; AUC = 0.703).Discussion and ImplicationsOur exploratory models create a starting point for the future development of precision health approaches that may be integrated into learning health systems that prompt providers with actionable information about who may benefit from discussions around serious illness goals-for-care. Future work is necessary to investigate those not considered in this study—that is, persons living with dementia who do not use hospice care so additional insights can be gathered around barriers to care.
DeletingSnord115genes in mice remodels monoaminergic systems activity in the brain toward cortico-subcortical imbalances
Authors: Marty Virginie , Butler Jasmine J , Coutens Basile , Chargui Oumaima , Chagraoui Abdeslam , Guiard Bruno P , De Deurwaerdère Philippe , Cavaillé Jérôme 
Published: August 2022

AbstractThe neuronal-specific SNORD115 has gathered interest because its deficiency may contribute to the pathophysiology of Prader-Willi syndrome (PWS), possibly by altering post-transcriptional regulation of the gene encoding the serotonin (HTR2C) receptor. Yet, Snord115-KO mice do not resume the main symptoms of PWS, and only subtle-altered A-to-I RNA editing of Htr2c mRNAs was uncovered. Because HTR2C signaling fine-tunes the activity of monoaminergic neurons, we addressed the hypothesis that lack of Snord115 alters monoaminergic systems. We first showed that Snord115 was expressed in both monoaminergic and non-monoaminergic cells of the ventral tegmental area (VTA) and the dorsal raphe nucleus (DRN) harboring cell bodies of dopaminergic and serotonergic neurons, respectively. Measuring the tissue level of monoamines and metabolites, we found very few differences except that the content of homovanillic acid—a metabolite of dopamine—was decreased in the orbitofrontal and prefrontal cortex of Snord115-KO mice. The latter effects were, however, associated with a few changes in monoamine tissue content connectivity across the 12 sampled brain regions. Using in vivo single-cell extracellular recordings, we reported that the firing rate of VTA dopaminergic neurons and DRN serotonergic neurons was significantly increased in Snord115-KO mice. These neural circuit dysfunctions were not, however, associated with apparent defects in binge eating, conditioned place preference to cocaine, cocaine-induced hyperlocomotion or compulsive behavior. Altogether, our multiscale study shows that the absence of Snord115 impacts central monoaminergic circuits to an extent that does not elicit gross behavioral abnormalities.
Integration of machine learning into process-based modelling to improve simulation of complex crop responses
Authors: Droutsas Ioannis , Challinor Andrew J , Deva Chetan R , Wang Enli 
Published: August 2022

AbstractMachine learning (ML) is the most advanced field of predictive modelling and incorporating it into process-based crop modelling is a highly promising avenue for accurate predictions of plant growth, development and yield. Here, we embed ML algorithms into a process-based crop model. ML is used within GLAM-Parti for daily predictions of radiation use efficiency, the rate of change of harvest index and the days to anthesis and maturity. The GLAM-Parti-ML framework exhibited high skill for wheat growth and development in a wide range of temperature, solar radiation and atmospheric humidity conditions, including various levels of heat stress. The model exhibited less than 20 % error in simulating the above-ground biomass, grain yield and the days to anthesis and maturity of three wheat cultivars in six countries (USA, Mexico, Egypt, India, the Sudan and Bangladesh). Moreover, GLAM-Parti reproduced around three-quarters of the observed variance in wheat biomass and yield. Existing process-based crop models rely on empirical stress factors to limit growth potential in simulations of crop response to unfavourable environmental conditions. The incorporation of ML into GLAM-Parti eliminated all stress factors under high-temperature environments and reduced the physiological model parameters down to four. We conclude that the combination of process-based crop modelling with the predictive capacity of ML makes GLAM-Parti a highly promising framework for the next generation of crop models.
Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository
Authors: Louis Elan D , Iglesias-Hernandez Daniella , Hernandez Nora C , Flowers Xena , Kuo Sheng-Han , Vonsattel Jean Paul G , Faust Phyllis L 
Published: August 2022

Abstract
The Essential Tremor Centralized Brain Repository is the largest repository of prospectively collected essential tremor (ET) brains (n = 231). Hence, we are uniquely poised to address several questions: What proportion of ET cases has Lewy pathology (LP)? What is the nature of that pathology and how does it relate to other comorbidities? Each brain had a complete neuropathological assessment, including α-synuclein immunostaining. We created a 10-category classification scheme to fully encapsulate the patterns of LP observed. Four metrics of cerebellar pathology were also quantified. Mean age at death = 89.0 ± 6.4 years. Fifty-eight (25.1%) had LP and 46 (19.9%) had early to late stages of Parkinson disease (PD). LP was very heterogeneous. Of 58 cases with LP, 14 (24.1%) clinically developed possible PD or PD after a latency of 5 or more years. There was a similar degree of cerebellar pathology in ET cases both with and without LP. In summary, 1 in 4 ET cases had LP—a proportion that seems higher than expected based on studies among control populations. Heterogeneous LP likely reflects clinical associations between ET and PD, and ET with Alzheimer disease-type neuropathology. These data further our understanding of ET and its relatedness to other degenerative diseases.
The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian ageing in mice
Authors: Wang Xin-Ying , Zhang Xin-Ge , Sang Yong-Juan , Chong Dan-Yang , Sheng Xiao-Qiang , Wang Hai-Quan , Yang Chao-Fan , Yan GuiJun , Sun Hai-Xiang , Li Chao-Jun 
Published: August 2022

AbstractAdverse nutritional conditions during the perinatal stage are related to early menopause in adulthood; however, the underlying mechanism is still unclear. Herein, we revealed that colostrum-activated ketone body elevation during the postnatal stage regulated primordial follicle reservoir size and then affected ovarian ageing. We found that the expression of the ketogenesis rate-limiting enzyme 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2) was largely enhanced during primordial follicle pool formation after birth and might be activated in the ovaries by colostrum. Reactive oxygen species (ROS) elevation in the ovaries leads to follicle apoptosis to deplete damaged follicles, while Hmgcs2 deficiency enhances follicle apoptosis and thus decreases the size of the primordial follicle pool and leads to premature ovarian ageing (POA), which might be related to the activation of cellular endogenous antioxidant system. All these defects could be rescued by ketone body administration, which suppressed ROS-activated follicle apoptosis. Our results suggest that the internal metabolic homeostasis of newborn mice is critical for the primordial reservoir and that any intrauterine and perinatal undernutrition could result in POA.