bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatic Steatosis and High-Normal Fasting Glucose as Risk Factors for Incident Prediabetes
Authors: Aizawa Toru , Nakasone Yasuto , Murai Norimitsu , Oka Rie , Nagasaka Shoichiro , Yamashita Koh , Sakuma Takahiro , Kiyosawa Kendo 
Published: July 2022

Abstract

Context
The role of hepatic steatosis (HS) in the initial stages of developing type 2 diabetes remains unclear.

Objective
We aimed to clarify the impact of HS indexed by Fatty Liver Index (FLI) and high-normal fasting plasma glucose (FPG) as risk factors for incident prediabetes in a nonobese cohort.

Methods
Data from 1125 participants with ADA-defined normal glucose metabolism (median age 52 years; BMI 23.1 kg/m2) were used for retrospective analysis. In the entire population, correlation between normal FPG and FLI was evaluated by multiple regression adjusted for age and sex. Follow-up data from 599 participants in whom 75-g OGTT was repeated 3.7 years later showed that 169 developed prediabetes. This was analyzed by the multivariate Cox proportional hazards model.

Results
In the entire population, FLI was positively correlated with FPG (P &lt; 0.01): mean FLI increased from 15.8 at FPG 4.2 mmol/L to 31.6 at FPG 5.5 mmol/L. Analysis of the 599 participants (2061 person-years) by Cox model, adjusted for sex, age, family history of diabetes, ISIMATSUDA, and Stumvoll-1, clarified an increased risk of prediabetes with high-normal FPG and FLI. Risk was increased 2.2 times with FLI ≥ 16.5 vs FLI &lt; 16.5, P &lt; 0.001, and increased 2.1 times in participants with FPG ≥ 5.3 mmol/L, P &lt; 0.001. Cutoff values (unadjusted) were obtained by ROC at the point of the largest Youden’s index using the entire range of the variables.

Conclusion
Even among nonobese individuals, HS indexed by FLI and a high-normal FPG (≥ 5.3 mmol/L) are risk factors for prediabetes, independently from insulin.
Opinions on the impact of studying/working remotely on vision impairment and the use of eye hygiene principles
Authors: Sowa Magdalena , Pulnik Karolina , Jurkiewicz Beata 
Published: August 2022

Introduction. The COVID-19 pandemic has forced the introduction of remote learning and working. Symptoms of digital eye fatigue are increasingly reducing the quality of life.
The aim of the study was to collect opinions on the impact of studying/working remotely on vision impairment and to find out the eye hygiene methods used by the respondents.
Material and methods. An original questionnaire consisting of 20 closed-ended questions was used for the study. The form was filled out by 194 people aged 18-55 years (mean: 23.15 ± 6.91 years) who were studying or working at least partially remotely.
Results. Respondents working remotely were most likely to spend more than 8 hours a day in front of the computer (49.02%), those working hybrid most often marked 5-6 hours (38.04%). Less than half - 44.85% - had a subjective feeling that their eyesight had deteriorated since they started learning/working remotely, and 19.07% declared that the deterioration of their eyesight had been confirmed by an examination with a specialist. Since starting to study/work online, respondents most often complained of eye fatigue (52.58%), dry eyes (34.54%), and sore/burning eyeballs (25.78%). Among eye hygiene rules, the largest percentage declared using a matte screen (48.97%), using "night mode" on an electronic device after dark (51.55%), sleeping for 7-9 hours (45.36%), and taking a break from the screen by blinking (41.24%). Few people are familiar with and use the exercise of closing and shading their eyes (6.70%) the 20-20-20 rule (4.12%), and do not use a smartphone/computer immediately before bed (2.58%).
Conclusions. Most of the respondents stated subjectively, or confirmed by a specialist, that their eyesight had deteriorated, and they associate this with learning/working remotely. The most common ocular symptom in the surveyed group was eye fatigue. There is a large deficit in the knowledge and application of eye hygiene principles that can benefit the organ of vision.
Management and outcomes of femoral periprosthetic fractures at the hip
Authors:   The COMPOSE Study Team
Published: July 2022

Aims The aim of this study was to describe the management and associated outcomes of patients sustaining a femoral hip periprosthetic fracture (PPF) in the UK population. Methods This was a multicentre retrospective cohort study including adult patients who presented to 27 NHS hospitals with 539 new PPFs between 1 January 2018 and 31 December 2018. Data collected included: management strategy (operative and nonoperative), length of stay, discharge destination, and details of post-treatment outcomes (reoperation, readmission, and 30-day and 12-month mortality). Descriptive analysis by fracture type was performed, and predictors of PPF management and outcomes were assessed using mixed-effects logistic regression. Results In all, 417 fractures (77%) were managed operatively and 122 (23%) conservatively. The median time to surgery was four days (interquartile range (IQR) 2 to 7). Of those undergoing surgery, 246 (59%) underwent revision and/or fixation and 169 (41%) fixation alone. The surgical strategy used differed by Unified Classification System for PPF type, with the highest rate of revision in B2/B3 fractures (both 77%, 176/228 and 24/31, respectively) and the highest rate of fixation alone in B1- (55/78; 71%) and C-type (49/65; 75%) fractures. Cemented stem fixation (odds ratio (OR) 2.66 (95% confidence interval (CI) 1.42 to 4.99); p = 0.002) and B2/B3 fracture type (OR 7.56 (95% CI 4.14 to 13.78); p < 0.001) were predictors of operative management. The median length of stay was 15 days (IQR 9 to 23), 12-month reoperation rate was 5.6% (n = 30), and 30-day readmission rate was 8.4% (n = 45). The 30-day and 12-month mortality rates were 5.2% (n = 28) and 21.0% (n = 113). Nonoperative treatment, older age, male sex, admission from residential or nursing care, and sustaining the PPF around a revision prosthesis were significant predictors of an increased 12-month mortality. Conclusion Femoral hip PPFs have mortality, reoperation, and readmission rates comparable with hip fracture patients. However, they have a longer wait for surgery, and surgical treatment is more complex. There is a need to create a national framework for data collection for this heterogeneous group of patients in order to understand the outcomes of different approaches to treatment. Cite this article: Bone Joint J 2022;104-B(8):997–1008 .
The Fragility Fracture Postoperative Mobilisation multicentre audit
Authors: Richardson Charlotte , Bretherton Christopher P. , Raza Mohsen , Zargaran Alexander , Eardley William G. P. , Trompeter Alex J. ,   on behalf of the FFPOM Collaborators
Published: July 2022

Aims The purpose of this study was to determine the weightbearing practice of operatively managed fragility fractures in the setting of publically funded health services in the UK and Ireland. Methods The Fragility Fracture Postoperative Mobilisation (FFPOM) multicentre audit included all patients aged 60 years and older undergoing surgery for a fragility fracture of the lower limb between 1 January 2019 and 30 June 2019, and 1 February 2021 and 14 March 2021. Fractures arising from high-energy transfer trauma, patients with multiple injuries, and those associated with metastatic deposits or infection were excluded. We analyzed this patient cohort to determine adherence to the British Orthopaedic Association Standard, “all surgery in the frail patient should be performed to allow full weight-bearing for activities required for daily living ”. Results A total of 19,557 patients (mean age 82 years (SD 9), 16,241 having a hip fracture) were included. Overall, 16,614 patients (85.0%) were instructed to perform weightbearing where required for daily living immediately postoperatively (15,543 (95.7%) hip fracture and 1,071 (32.3%) non-hip fracture patients). The median length of stay was 12.2 days (interquartile range (IQR) 7.9 to 20.0) (12.6 days (IQR 8.2 to 20.4) for hip fracture and 10.3 days (IQR 5.5 to 18.7) for non-hip fracture patients). Conclusion Non-hip fracture patients experienced more postoperative weightbearing restrictions, although they had a shorter hospital stay. Patients sustaining fractures of the shaft and distal femur had a longer median length of stay than demographically similar patients who received hip fracture surgery. We have shown a significant disparity in weightbearing restrictions placed on patients with fragility fractures, despite the publication of a national guideline. Surgeons intentionally restrict postoperative weightbearing in the majority of non-hip fractures, yet are content with unrestricted weightbearing following operations for hip fractures. Cite this article: Bone Joint J 2022;104-B(8):972–979.
Artificial intelligence and computer vision in orthopaedic trauma
Authors: Prijs Jasper , Liao Zhibin , Ashkani-Esfahani Soheil , Olczak Jakub , Gordon Max , Jayakumar Prakash , Jutte Paul C. , Jaarsma Ruurd L. , IJpma Frank F. A. , Doornberg Job N. ,   on behalf of the Machine Learning Consortium
Published: July 2022

Artificial intelligence (AI) is, in essence, the concept of ‘computer thinking’, encompassing methods that train computers to perform and learn from executing certain tasks, called machine learning, and methods to build intricate computer models that both learn and adapt, called complex neural networks. Computer vision is a function of AI by which machine learning and complex neural networks can be applied to enable computers to capture, analyze, and interpret information from clinical images and visual inputs. This annotation summarizes key considerations and future perspectives concerning computer vision, questioning the need for this technology (the ‘why’), the current applications (the ‘what’), and the approach to unlocking its full potential (the ‘how’). Cite this article: Bone Joint J 2022;104-B(8):911–914.
Artificial intelligence for image analysis in total hip and total knee arthroplasty
Authors: Gurung Binay , Liu Perry , Harris Peter D. R. , Sagi Amit , Field Richard E. , Sochart David H. , Tucker Keith , Asopa Vipin 
Published: July 2022

Aims Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are common orthopaedic procedures requiring postoperative radiographs to confirm implant positioning and identify complications. Artificial intelligence (AI)-based image analysis has the potential to automate this postoperative surveillance. The aim of this study was to prepare a scoping review to investigate how AI is being used in the analysis of radiographs following THA and TKA, and how accurate these tools are. Methods The Embase, MEDLINE, and PubMed libraries were systematically searched to identify relevant articles. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews and Arksey and O’Malley framework were followed. Study quality was assessed using a modified Methodological Index for Non-Randomized Studies tool. AI performance was reported using either the area under the curve (AUC) or accuracy. Results Of the 455 studies identified, only 12 were suitable for inclusion. Nine reported implant identification and three described predicting risk of implant failure. Of the 12, three studies compared AI performance with orthopaedic surgeons. AI-based implant identification achieved AUC 0.992 to 1, and most algorithms reported an accuracy > 90%, using 550 to 320,000 training radiographs. AI prediction of dislocation risk post-THA, determined after five-year follow-up, was satisfactory (AUC 76.67; 8,500 training radiographs). Diagnosis of hip implant loosening was good (accuracy 88.3%; 420 training radiographs) and measurement of postoperative acetabular angles was comparable to humans (mean absolute difference 1.35° to 1.39°). However, 11 of the 12 studies had several methodological limitations introducing a high risk of bias. None of the studies were externally validated. Conclusion These studies show that AI is promising. While it already has the ability to analyze images with significant precision, there is currently insufficient high-level evidence to support its widespread clinical use. Further research to design robust studies that follow standard reporting guidelines should be encouraged to develop AI models that could be easily translated into real-world conditions. Cite this article: Bone Joint J 2022;104-B(8):929–937.
Arthroscopic bone graft and fixation for proximal scaphoid nonunions
Authors: Wu Feiran , Zhang Yuhao , Liu Bo 
Published: July 2022

Aims This study aims to report the outcomes in the treatment of unstable proximal third scaphoid nonunions with arthroscopic curettage, non-vascularized bone grafting, and percutaneous fixation. Methods This was a retrospective analysis of 20 patients. All cases were delayed presentations (n = 15) or failed nonoperatively managed scaphoid fractures (n = 5). Surgery was performed at a mean duration of 27 months (7 to 120) following injury with arthroscopic debridement and arthroscopic iliac crest autograft. Fracture fixation was performed percutaneously with Kirschner (K)-wires in 12 wrists, a headless screw in six, and a combination of a headless screw and single K-wire in two. Clinical outcomes were assessed using grip strength, patient-reported outcome measures, and wrist range of motion (ROM) measurements. Results Intraoperatively, established avascular necrosis of the proximal fragment was identified in ten scaphoids. All fractures united within 16 weeks, confirmed by CT. At a mean follow-up of 31 months (12 to 64), there were significant improvements in the Patient-Rated Wrist Evaluation, Mayo Wrist Score, abbreviated Disabilities of the Arm, Shoulder and Hand score, wrist ROM, grip strength, and the patients’ subjective pain score. No peri- or postoperative complications were encountered. Conclusion Our data indicate that arthroscopic bone grafting and fixation with cancellous autograft is a viable method in the treatment of proximal third scaphoid nonunions, regardless of the vascularity of the proximal fragment. Cite this article: Bone Joint J 2022;104-B(8):946–952.
Cost-utility analysis of cemented hemiarthroplasty versus hydroxyapatite-coated uncemented hemiarthroplasty for the treatment of displaced intracapsular hip fractures
Authors: Png May Ee , Petrou Stavros , Fernandez Miguel A. , Achten Juul , Parsons Nicholas , McGibbon Alwin , Gould Jenny , Griffin Xavier L. , Costa Matthew L. ,   on behalf of the WHiTE 5 trial collaborators
Published: July 2022

AimsThe aim of this study was to compare the cost-effectiveness of cemented hemiarthroplasty (HA) versus hydroxyapatite-coated uncemented HA for the treatment of displaced intracapsular hip fractures in older adults.MethodsA within-trial economic evaluation was conducted based on data collected from the World Hip Trauma Evaluation 5 (WHiTE 5) multicentre randomized controlled trial in the UK. Resource use was measured over 12 months post-randomization using trial case report forms and participant-completed questionnaires. Cost-effectiveness was reported in terms of incremental cost per quality-adjusted life year (QALY) gained from the NHS and personal social service perspective. Methodological uncertainty was addressed using sensitivity analysis, while decision uncertainty was represented graphically using confidence ellipses and cost-effectiveness acceptability curves.ResultsThe base-case analysis showed that cemented implants were cost-saving (mean cost difference -£961 (95% confidence interval (CI) -£2,292 to £370)) and increased QALYs (mean QALY difference 0.010 (95% CI 0.002 to 0.017)) when compared to uncemented implants. The probability of the cemented implant being cost-effective approximated between 95% and 97% at alternative cost-effectiveness thresholds held by decision-makers, and its net monetary benefit was positive. The findings remained robust against all the pre-planned sensitivity analyses.ConclusionThis study shows that cemented HA is cost-effective compared with hydroxyapatite-coated uncemented HA in older adults with displaced intracapsular hip fractures. Cite this article: Bone Joint J 2022;104-B(8):922–928.
Beta-caryophyllene prevents the defects in trabecular bone caused by Vitamin D deficiency through pathways instated by increased expression of klotho
Authors: Dong Wei , Postlethwaite Bradley C. , Wheller Patricia A. , Brand David , Jiao Yan , Li Wei , Myers Linda K. , Gu Weikuan 
Published: August 2022

Aims This study investigated the effects of β-caryophyllene (BCP) on protecting bone from vitamin D deficiency in mice fed on a diet either lacking (D-) or containing (D+) vitamin D. Methods A total of 40 female mice were assigned to four treatment groups (n = 10/group): D+ diet with propylene glycol control, D+ diet with BCP, D-deficient diet with control, and D-deficient diet with BCP. The D+ diet is a commercial basal diet, while the D-deficient diet contains 0.47% calcium, 0.3% phosphorus, and no vitamin D. All the mice were housed in conditions without ultraviolet light. Bone properties were evaluated by X-ray micro-CT. Serum levels of klotho were measured by enzyme-linked immunosorbent assay. Results Under these conditions, the D-deficient diet enhanced the length of femur and tibia bones (p < 0.050), and increased bone volume (BV; p < 0.010) and trabecular bone volume fraction (BV/TV; p < 0.010) compared to D+ diet. With a diet containing BCP, the mice exhibited higher BV and bone mineral density (BMD; p < 0.050) than control group. The trabecular and cortical bone were also affected by vitamin D and BCP. In addition, inclusion of dietary BCP improved the serum concentrations of klotho (p < 0.050). In mice, klotho regulates the expression level of cannabinoid type 2 receptor (Cnr2) and fibroblast growth factor 23 (Fgf23) through CD300a. In humans, data suggest that klotho is connected to BMD. The expression of klotho is also associated with bone markers. Conclusion These data indicate that BCP enhances the serum level of klotho, leading to improved bone properties and mineralization in an experimental mouse model. Cite this article: Bone Joint Res 2022;11(8):528–540.
El papel del ocio en la intervención psicosocial con víctimas de la trata: una revisión sistemática
Authors: Chacón Alexandra , Codina Nuria 
Published: July 2022

Introducción: La trata de personas con finalidad de explotación sexual es una práctica esclavista que acarrea un excelso grado de violencia; requiriendo que la intervención psicosocial preste recursos centrados en la recuperación psicológica de las víctimas. En este sentido, el ocio es un recurso terapéutico que permite afrontar los estresores traumáticos y abordar el desarraigo y los estigmas que sufren las víctimas sexuales; alejándose así de las extendidas intervenciones asistencialistas y paliativas. Sin embargo, parecen poco generalizadas las intervenciones que incorporan el ocio terapéutico. Objetivo: Realizar una revisión sistemática de los trabajos publicados respecto a intervenciones con mujeres víctimas de explotación sexual que contemplan el ocio terapéutico. Metodología: Se revisan las bases de datos Psicodoc, PsycInfo y Sociological Abstracts, utilizando las palabras claves, en castellano, víctimas sexuales o prostitutas, intervención, ocio y en inglés, sexual victim o prostitute, intervention, leisure.Resultados: Se identificaron un total de 725 publicaciones mayoritariamente de orientación sociológica. Después de los cribados quedaron 19 trabajos, los cuales también fueron descartados tras un análisis del contenido de los mismos. Discusión: Los resultados reflejan como la intervención psicosocial orientada a recuperar en su integridad a las víctimas de la violencia sexual no está documentada ni registrada en bases de datos científicas. Conclusiones: Habiendo evidenciado el significativo grado de desatención a la recuperación integral de las víctimas de la trata, se reclama la necesidad de difundir y facilitar experiencias en la gestión del ocio terapéutico como herramienta para intervenir en este colectivo.
Subjectivities and the Space of Possibilities in Youth Programs: Countering Majoritarian Stories as Social Change in the Australian Context
Authors: Keast Samuel P , Sonn Christopher C 
Published: July 2022

The status quo of many not-for-profit organisations is well-intentioned service provision often coupled with an absence of critical understanding sustained by the restricting nature of neoliberal bureaucracy and funding. In this context, programs aimed at assisting young people from marginalised communities can become mired in individualistic thinking that constrains the space of possibilities for young people through depoliticisation and decontextualization of their realities and thus the kinds of subjectivities available to them. The challenge for the evaluation we discuss in this paper was not only to evaluate the outcomes of the program, but to promote community narratives about the realities for young racialized people in Australia that counter majoritarian stories. We conclude that social change begins within the multidirectional relationships and contact zones of the stakeholders, participants and researchers of youth programs. This means, extending the focus beyond generic youth development and moving toward engaging young people in critical social analysis and empowering them as future social change agents in their communities.
Correlates of bike share use and its association with weight status at an urban university
Authors: Stahley Lawrence H. , Camhi Sarah M. , Wright Julie A. , Troped Philip J. 
Published: August 2022

Background
Research on the influences on bike share use and potential favorable relationships between use and obesity is limited, particularly in the U.S. context. Therefore, the aims of this exploratory study were to examine correlates of awareness and use of Boston’s Bluebikes bike share system and assess the association between use and weight status.

Methods
Students, faculty, and staff (n = 256) at a public urban university completed an online survey that assessed sociodemographic, behavioral, and physical activity characteristics, Bluebikes awareness, and use of Bluebikes and personal bikes. Multivariable logistic regression models were estimated to examine associations between sociodemographic and behavioral factors and bike share awareness and use; and between use and overweight/obesity status.

Results
Respondents were mostly students (72.2%), female (69.1%), White (62.1%), and the mean age was 32.4±13.8 years. The percentage of respondents classified as aware of Bluebikes was 33.6% with only 12.9% reporting any use of the system. Living in a community where bike share stations were located (odds ratio (OR) = 2.01, 95% confidence interval (CI): 1.10, 3.67), personal bike ownership (OR = 2.27, 95% CI:1.27, 4.45), and not exclusively commuting to campus via car (OR = 3.19, 95% CI:1.63, 6.22) had significant positive associations with awareness. Living in a bike share community (OR = 2.34; 95% CI:1.04, 5.27) and personal bike ownership (OR = 3.09; 95% CI:1.27, 7.52) were positively associated with bike share use. Any reported use of Bluebikes was associated with 60% lower odds of being overweight/obese (OR = 0.40; 95% CI:0.17, 0.93).

Conclusions
Several environmental and behavioral variables, including access to stations and personal bicycle ownership, were significantly associated with Bluebikes awareness and use. Findings also suggest a potential benefit to bike share users in terms of maintaining a healthy weight, though further longitudinal studies are needed to rule out the possibility that more active and leaner individuals tend to use bike share more frequently.