bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of acoustic characteristics of voluntary expiratory sounds produced before and immediately after swallowing
Authors: Hattori Shoma , Nozue Shinji , Ihara Yoshiaki , Takahashi Koji 
Published: January 2022

AbstractTo evaluate the expiratory sounds produced during swallowing recorded simultaneously with videofluorographic examination of swallowing (VF) using fast Fourier transform (FFT), and to examine the relationship between dysphagia and its acoustic characteristics. A total of 348 samples of expiratory sounds were collected from 61 patients with dysphagia whose expiratory sounds were recorded during VF. The VF results were evaluated by one dentist and categorized into three groups: safe group (SG), penetration group (PG), and aspiration group (AG). The duration and maximum amplitude of expiratory sounds produced were measured as the domain characteristics on the time waveform of these sounds and compared among the groups. Time window-length appropriate for FFT and acoustic discriminate values (AD values) of SG, PG, and AG were also investigated. The groups were analyzed using analysis of variance and Scheffé's multiple comparison method. The maximum amplitude of SG was significantly smaller than those of PG and AG. The mean duration in SG (2.05 s) was significantly longer than those in PG (0.84 s) and AG (0.96 s). The AD value in SG was significantly lower than those in PG and AG. AD value detects penetration or aspiration, and can be useful in screening for dysphagia.
Serious role of non-quarantined COVID-19 patients for random walk simulations
Authors: Nakagiri Nariyuki , Sato Kazunori , Sakisaka Yukio , Tainaka Kei-ichi 
Published: January 2022

AbstractThe infectious disease (COVID-19) causes serious damages and outbreaks. A large number of infected people have been reported in the world. However, such a number only represents those who have been tested; e.g. PCR test. We focus on the infected individuals who are not checked by inspections. The susceptible-infected-recovered (SIR) model is modified: infected people are divided into quarantined (Q) and non-quarantined (N) agents. Since N-agents behave like uninfected people, they can move around in a stochastic simulation. Both theory of well-mixed population and simulation of random-walk reveal that the total population size of Q-agents decrease in spite of increasing the number of tests. Such a paradox appears, when the ratio of Q exceeds a critical value. Random-walk simulations indicate that the infection hardly spreads, if the movement of all people is prohibited ("lockdown"). In this case the infected people are clustered and locally distributed within narrow spots. The similar result can be obtained, even when only non-infected people move around. However, when both N-agents and uninfected people move around, the infection spreads everywhere. Hence, it may be important to promote the inspections even for asymptomatic people, because most of N-agents are mild or asymptomatic.
Effect of electron and X-ray irradiation on microbiological and chemical parameters of chilled turkey
Authors: Bliznyuk Ulyana , Avdyukhina Valentina , Borshchegovskaya Polina , Bolotnik Timofey , Ipatova Victoria , Nikitina Zoya , Nikitchenko Alexander , Rodin Igor , Studenikin Felix , Chernyaev Alexander , Yurov Dmitry 
Published: January 2022

AbstractThe purpose of this work was to compare the effect of electron and X-ray irradiation on microbiological content and volatile organic compounds in chilled turkey meat. Dose ranges which significantly suppress the pathogenic microflora while maintaining the organoleptic properties of the turkey meat are different for electron and X-ray irradiation. According to the study it is recommended to treat chilled turkey using X-ray irradiation with the dose ranging from 0.5 to 0.75 kGy, while in electron irradiation permissible doses should be within 0.25–1 kGy. Three main groups of volatile compounds: alcohols, ketones, and aldehydes—were found in irradiated and non-irradiated samples of turkey meat. It was found that the total amount of aldehydes, which are responsible for the formation of a specific odor of irradiated meat products, increases exponentially with the increase in the absorbed dose for both types of irradiation. It was established that acetone can be used as a potential marker of the fact of exposure of low-fat meat products to ionizing radiation.
Feasibility study of immersive virtual prism adaptation therapy with depth-sensing camera using functional near-infrared spectroscopy in healthy adults
Authors: Cho Sungmin , Chang Won Kee , Park Jihong , Lee Seung Hyun , Lee Jongseung , Han Cheol E. , Paik Nam-Jong , Kim Won-Seok 
Published: January 2022

AbstractPrism Adaptation (PA) is used to alleviate spatial neglect. We combined immersive virtual reality with a depth-sensing camera to develop virtual prism adaptation therapy (VPAT), which block external visual cues and easily quantify and monitor errors than conventional PA. We conducted a feasibility study to investigate whether VPAT can induce behavioral adaptations by measuring after-effect and identifying which cortical areas were most significantly activated during VPAT using functional near-infrared spectroscopy (fNIRS). Fourteen healthy subjects participated in this study. The experiment consisted of four sequential phases (pre-VPAT, VPAT-10°, VPAT-20°, and post-VPAT). To compare the most significantly activated cortical areas during pointing in different phases against pointing during the pre-VPAT phase, we analyzed changes in oxyhemoglobin concentration using fNIRS during pointing. The pointing errors of the virtual hand deviated to the right-side during early pointing blocks in the VPAT-10° and VPAT-20° phases. There was a left-side deviation of the real hand to the target in the post-VPAT phase, demonstrating after-effect. The most significantly activated channels during pointing tasks were located in the right hemisphere, and possible corresponding cortical areas included the dorsolateral prefrontal cortex and frontal eye field. In conclusion, VPAT may induce behavioral adaptation with modulation of the dorsal attentional network.
Pain control according to the periprostatic nerve block site in magnetic resonance imaging/transrectal targeted prostate biopsy
Authors: Yoo Jeong Woo , Koo Kyo Chul , Chung Byung Ha , Lee Kwang Suk 
Published: January 2022

AbstractWe analyzed the intensity of pain at each site of systemic prostate biopsy (SBx) and compared the intensity of pain among magnetic resonance (MRI)-targeted transrectal biopsies according to the periprostatic nerve block (PNB) site. We collected data from 229 consecutive patients who had undergone MRI-targeted biopsy. Patients were stratified into two groups according to the site of PNB (base versus base and apex PNB). Pain was quantified at the following time points: probe insertion, injection at the prostate base, injection at the prostate apex, MRI cognitive biopsy (CBx), MRI/transrectal ultrasound fusion biopsy (FBx), SBx, and 15 min after biopsy. For all biopsy methods, the average pain were significantly higher in the base PNB group than in the base and apex PNB group (CBx, p < 0.001; FBx, p = 0.015; SBx, p < 0.001). In the base and apex PNB group, FBx was significantly more painful than SBx (p = 0.024). Overall, regardless of the PNB site, pain at the anterior sites was more than that at the posterior sites in FBx (p = 0.039). Base and apex PNB provided better overall pain control than base-only PNB in all biopsy methods. In the base and apex PNB group, FBx was more painful than CBx and SBx.
Pigmentary abnormality without significant drusen as a risk factor for late age-related macular degeneration
Authors: Lee Junwon , Kang Hyun Goo , Kim Hae Rang , Lee Christopher Seungkyu , Kim Min , Kim Sung Soo , Byeon Suk Ho 
Published: January 2022

AbstractWe investigated the incidence and risk factors of late age-related macular degeneration (AMD) in the fellow eye (FE) without significant drusen of patients with unilateral exudative macular neovascularization (MNV). In this retrospective study, 241 eligible patients who were followed-up for more than 3 years were enrolled. We analyzed the incidence and hazard ratios (HRs) of late AMD in the FE according to demographic and ophthalmologic variables. Hypopigmentation on color fundus photography (CFP) corresponds to shallow irregular RPE elevation (SIRE), so-called “double-layer sign” and/or “attenuation or disruption of RPE and/or ellipsoid zone” on OCT. The 5-year incidence of FE exudative MNV conversion was 8.6%. The 5-year incidence of FE exudative MNV of large hypopigmentation (≥ 0.5 disc area; DA) and small hypopigmentation (< 0.5 DA) on CFP, and SIRE (≥ 1000 µm) and small RPE elevation (< 1000 µm) on OCT were 36.2%, 14.2%, 55.0%, and 15.6%, respectively. The multivariate Cox proportional hazard model revealed that large hypopigmentation, small hypopigmentation, SIRE, and small RPE elevation showed HRs of 23.230, 8.037, 132.589, and 41.823 for FE exudative MNV occurrence, respectively. Hypopigmentation on CFP and SIRE on OCT could represent the same lesion. Even small hypopigmentation and small RPE elevation were significant risk factors for progression to exudative MNV.
Enhanced production of pinosylvin stilbene with aging of Pinus strobus callus and nematicidal activity of callus extracts against pinewood nematodes
Authors: Koo Hyo Bin , Hwang Hwan-Su , Han Jung Yeon , Cheong Eun Ju , Kwon Yong-Soo , Choi Yong Eui 
Published: January 2022

AbstractPinosylvin stilbenes are phenolic compounds mainly occurring in the Pinaceae family. We previously reported that the accumulation of two pinosylvin stilbene compounds, dihydropinosylvin methyl ether (DPME) and pinosylvin monomethyl ether (PME), in Pinus strobus trees was highly enhanced by infection with pine wood nematodes (PWNs: Bursaphelenchus xylophilus), and these two compounds showed strong nematicidal activity against PWNs. In this work, we established a system of pinosylvin stilbene (DPME and PME) production via the in vitro culture of P. strobus calli, and we examined the nematicidal activity of callus extracts. Calli were induced from the culture of mature zygotic embryos of P. strobus. Optimized growth of calli was obtained in 1/2 Litvay medium with 1.0 mg/L 2,4-D and 0.5 mg/L BA. DPME and PME accumulation did not occur in nonaged (one-month-old) calli but increased greatly with prolonged callus culture. The concentrations of DPME and PME in three-month-old dark-brown calli were 6.4 mg/g DW and 0.28 mg/g DW, respectively. The effect of methyl jasmonate treatment on the accumulation of DPME and PME was evaluated in cell suspension culture of P. strobus. However, the treatment appeared to show slight increase of DPME accumulation compared to callus browning. A test solution prepared from crude ethanol extracts from aged calli (three months old) containing 120 µg/ml DPME and 5.16 µg/ml PME treated with PWNs resulted in 100% immobilization of the adult PWNs and 66.7% immobilization of the juvenile PWNs within 24 h. However, nonaged callus extracts did not show any nematicidal activity against juvenile PWNs and showed less than 20% nematicidal activity against adult PWNs. These results indicate that pinosylvin stilbenes can be effectively produced by prolonged culture of P. strobus calli, can be isolated using simple ethanolic extraction, and are applicable as beneficial eco-friendly compounds with nematicidal activity against PWNs.
Endoscopic submucosal dissection for colorectal neoplasia: outcomes and predictors of recurrence
Authors: Maselli Roberta , Spadaccini Marco , Belletrutti Paul J. , Galtieri Piera Alessia , Attardo Simona , Carrara Silvia , Anderloni Andrea , Fugazza Alessandro , Ferrara Elisa Chiara , Pellegatta Gaia , Iannone Andrea , Hassan Cesare , Repici Alessandro 
Published: January 2022

Abstract
Background and study aims The role of endoscopic submucosal dissection (ESD) for colorectal lesions in Western communities is unclear and its adoption is still limited. The aim of this study is to assess the long-term outcomes of a large cohort of patients treated with colorectal ESD in a tertiary Western center.
Patients and methods A retrospective analysis was conducted on patients treated by ESD for superficial colorectal lesions between February 2011 and November 2019. The primary outcome was the recurrence rate. Secondary outcomes were en-bloc and R0 resection rates, procedural time, adverse events (AEs), and need for surgery. The curative resection rate was assessed for submucosal invasive lesions.
Results A total of 327 consecutive patients, median age 69 years (IQR 60–76); 201 men (61.5 %) were included in the analysis. Of the lesions, 90.8 % were resected in an en-bloc fashion. The rate of R0 resection was 83.1 % (217/261) and 44.0 % (29/66) for standard and hybrid ESD techniques, respectively. Submucosal invasion and piecemeal resection independently predicted R1 resections. A total of 18(5.5 %) intra-procedural AEs (perforation:11, bleeding:7) and 12(3.7 %) post-procedural AEs occurred (perforation:2, bleeding: 10). Eighteen adenoma recurrences per 1,000 person-years (15cases, 5.6 %) were detected after a median follow-up time of 36 months. All recurrences were detected within 12 months. No carcinoma recurrences were observed. R1 resection status and intra-procedural AEs independently predicted recurrences with seven vs 150 recurrences per 1,000 person-years in the R0 vs R1 group, respectively.
Conclusions Colorectal ESD is a safe and effective option for managing superficial colorectal neoplasia in a Western setting, with short and long-terms outcomes comparable to Eastern studies. En-bloc R0 resection and absence of intra-procedural AEs are associated with reduced risk of recurrence.
Real-time diagnostic accuracy of blue light imaging, linked color imaging and white-light endoscopy for colorectal polyp characterization
Authors: Houwen Britt B.S.L. , Vleugels Jasper L.A. , Pellisé Maria , Rivero-Sánchez Liseth , Balaguer Francesc , Bisschops Raf , Tejpar Sabine , Repici Alessandro , Ramsoekh D. , Jacobs M. A.J.M , Schreuder Ramon-Michel , Kamiński Michal F. , Rupińska Maria , Bhandari Pradeep , van Oijen M. G.H. , Koens L. , Bastiaansen Barbara A.J. , Tytgat K. M.A.J. , Fockens Paul , Dekker Evelien , Hazewinkel Yark 
Published: January 2022

AbstractBackground and study aims Fujifilm has developed a novel ELUXEO 7000 endoscope system that employs light-emitting diodes (LEDs) at four different wavelengths as light sources that enable blue light imaging (BLI), linked color imaging (LCI), and high-definition white-light endoscopy (HD-WLE). The aim of this study was to address the diagnostic accuracy of real-time polyp characterization using BLI, LCI and HD-WLE (ELUXEO 7000 endoscopy system).Patients methods This is a prespecified post-hoc analysis of a prospective study in which 22 experienced endoscopists (> 2,000 colonoscopies) from eight international centers participated. Using a combination of BLI, LCI, and HD-WLE, lesions were endoscopically characterized including a high- or low-confidence statement. Per protocol, digital images were created from all three imaging modalities. Histopathology was the reference standard. Endoscopists were familiar with polyp characterization, but did not take dedicated training for purposes of this study.Results Overall, 341 lesions were detected in 332 patients. Of the lesions, 269 histologically confirmed polyps with an optical diagnosis were included for analysis (165 adenomas, 27 sessile serrated lesions, and 77 hyperplastic polyps). Overall, polyp characterization was performed with high confidence in 82.9 %. The overall accuracy for polyp characterization was 75.1 % (95 % confidence interval [CI] 69.5–80.1 %), compared with an accuracy of 78.0 % (95 % CI 72.0–83.2 %) for high confidence assignments. The accuracy for endoscopic characterization for diminutive polyps was 74.7 % (95 %CI 68.4–80.3 %), compared with an accuracy of 78.2 % (95 % CI 71.4–84.0 %) for high-confidence assignments.Conclusions The diagnostic accuracy of BLI, LCI, and HD-WLE by experienced endoscopist for real-time polyp characterization seems limited (NCT03344289).
Effects of basic endoscopic handling and care training on gastrointestinal endoscopy logistics
Authors: Mahawongkajit Prasit , Techagumpuch Ajjana , Auksornchat Kharikarn 
Published: January 2022

Abstract
Background and study aims The current practice of endoscopists is undergoing a dramatic revolution due to emerging endoscopy practices. Increasing use of gastrointestinal endoscopy has led to hospital budgets setting aside funds specifically related to damage to endoscopic instruments. Therefore, training in understanding endoscopic equipment, handling techniques, and equipment care can be helpful in addressing this issue. The aim of this study was to investigate the effects of educational courses and training about basic endoscopic handling and care in gastrointestinal endoscopic care and services.
Methods A number of new endoscopists, nurses, and nurse assistants were enrolled in a course for training in basic endoscopic handling and care. Data on the type of damage, cause, cost, and timing of endoscopic repair were prospectively collected. Data from the post-training period then were compared with retrospective data from the pre-training period.
Results This study demonstrated that after training, there was less damage to endoscopes, lower costs associated with it, and repair times were shorter for endoscopes than before the training course. Post-training results indicated savings of a total of $ 40,617.21 or £ 29,539.78 and 102.6 days per damaged endoscope.
Conclusions Basic endoscopic handling and care training plays an important role for both endoscopists and nurses, as well as in endoscopy facilities, specifically in avoiding the nuisance of unwanted and broken endoscopes. This could be beneficial for both hospital finances and endoscopic services.
[18F]DCFPyL PET/CT for Imaging of Prostate Cancer
Authors: Rowe Steven P. , Buck Andreas , Bundschuh Ralph A. , Lapa Constantin , Serfling Sebastian E. , Derlin Thorsten , Higuchi Takahiro , Gorin Michael A. , Pomper Martin G. , Werner Rudolf A. 
Published: January 2022

AbstractProstate-specific membrane antigen (PSMA)-directed positron emission tomography (PET) has gained increasing interest for imaging of men affected by prostate cancer (PC). In recent years, 68Ga-labeled PSMA compounds have been widely utilized, although there is a trend towards increased utilization of 18F-labeled agents. Among others, [18F]DCFPyL (piflufolastat F 18, PYLARIFY) has been tested in multiple major trials, such as OSPREY and CONDOR, which provided robust evidence on the clinical utility of this compound for staging, restaging, and change in management. Recent explorative prospective trials have also utilized [18F]DCFPyL PET/CT for response assessment, e.g., in patients under abiraterone or enzalutamide, rendering this 18F-labeled PSMA radiotracer as an attractive biomarker for image-guided strategies in men with PC. After recent approval by the U.S. Food and Drug Administration, one may expect more widespread use, not only in the U.S., but also in Europe in the long term. In the present review, we will provide an overview of the current clinical utility of [18F]DCFPyL in various clinical settings for men with PC.
Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress
Authors: Liao Yiji , Chen Chen-Hao , Xiao Tengfei , de la Peña Avalos Bárbara , Dray Eloise V. , Cai Changmeng , Gao Shuai , Shah Neel , Zhang Zhao , Feit Avery , Xue Pengya , Liu Zhijie , Yang Mei , Lee Ji Hoon , Xu Han , Li Wei , Mei Shenglin , Pierre Roodolph S. , Shu Shaokun , Fei Teng , Duarte Melissa , Zhao Jin , Bradner James E. , Polyak Kornelia , Kantoff Philip W. , Long Henry , Balk Steven P. , Liu X. Shirley , Brown Myles , Xu Kexin 
Published: January 2022

Significance
We identified a group of DNA repair genes directly induced by EZH2 and repressed by EZH2 inhibitors. Expression of these genes predicts the response of wild-type EZH2-harboring solid tumors to EZH2 inhibitors. Most importantly, our findings lay the foundation for the development of a combination therapy that combines EZH2 inhibitors and DNA damaging agents or drugs that block DNA repair for the treatment of castration-resistant prostate cancer and other solid tumors.
The discourse markeralein Bislama oral narratives
Authors: Alvanoudi Angeliki , Guérin Valérie 
Published: January 2022

AbstractThis study takes us to the South Pacific and concentrates on Bislama, one of the dialects of Melanesian pidgin (Siegel 2008: 4) and one of the official languages of Vanuatu. We take a discourse analysis perspective to map out the functions ofale, a conspicuous discourse marker in conversations and narratives. UsingLabov & Waletzky (1967)model, we analyze the use ofalein narratives from the bookBig Wok: Storian blong Wol Wo Tu long Vanuatu(Lindstrom & Gwero 1998) and determine thataleis a discourse marker which indicates temporal sequence and consequence, frames speech reports and closes a digression. We conclude our study by considering a possible historical development ofale. We map out how Frenchallezcould have become Bislamaaleusing imposition and functional transfer (Siegel 2008;Winford 2013a) of vernacular discourse markers (such asgoin Nguna).
A review of the properties, synthesis and applications of lanthanum copper oxychalcogenides
Authors: Li Menglu , Wang Ning , Zhang Sa , Hu Jutao , Xiao Haiyan , Gong Hengfeng , Liu Zijiang , Qiao Liang , Zu Xiaotao 
Published: January 2022

Abstract
The study of layered materials has been a significant and fascinating area due to their unique physical and chemical properties. Among various layered materials, lanthanum copper oxychalcogenides [LaCuOX (X = S, Se, Te)] have drawn a lot of attention from researchers. The study of LaCuOX was initially focused on optoelectronic performance due to their excellent optical and electronic properties. Recently, it was found that the layered LaCuOX materials also exhibit good thermoelectric (TE) properties, providing an opportunity to achieve high energy conversion efficiency through the TE effects. In this report, an overview of recent advances in LaCuOX research is provided, including crystal and electronic structure, synthetic methods, physical properties and practical applications as well as some strategies to optimize their transport properties. Theoretical and experimental results on LaCuOX crystals or thin films are both discussed. Finally, the challenges and outlook for LaCuOX are evaluated based on current progress.
Topological viewpoint of two-dimensional group III–V and IV–IV compounds in the presence of electric field and spin–orbit coupling by density functional theory and tight-binding model
Authors: Baradaran A , Ghaffarian M 
Published: January 2022

Abstract
Using the tight-binding (TB) model and density functional theory, the topological invariant of the two-dimensional (2D) group III–V and IV–IV compounds are studied in the absence and the presence of an external perpendicular electric field and spin–orbit coupling. It will be recognized that a critical value of these parameters changes the topological invariant of 2D graphene-like compounds. The significant effects of an external electric field and spin–orbit coupling are considered to the two-center overlap integrals of the Slater–Koster model involved in band structures, changing band-gap, and tuning the topological phase transition between ordinary and quantum spin Hall regime. These declare the good consistency between two theories: TB and density functional. So, this study reveals topological phase transition in these materials. Our finding paves a way to extend an effective Hamiltonian, and may instantly clear some computation aspects of the study in the field of spintronic based on the first-principles methods.