bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leader diffuse status and leadership outcomes: Towards an integrative framework
Authors: Lianidou Theano , Zheng Wei 
Published: November 2022

AbstractThis review seeks to enrich our understanding of how a leader's status influences leadership outcomes such as motivation to lead, leader emergence and perceived leader effectiveness. The focus is on the leader's diffuse status, that is, status derived from demographic (e.g., gender and race) and physical (e.g., height and body shape) characteristics. Drawing insights from empirical findings and their theoretical underpinnings, we (1) highlight the need to explicitly model the leader's diffuse status as a mediator in the relationship between leader demographic and physical characteristics and leadership outcomes, (2) differentiate the effects of the leader's diffuse status as perceived by others (interpersonal level) and the leader's diffuse status as perceived by the leader (intrapersonal level) and (3) synthesize a wide range of contextual factors that influence the degree to which the leader's demographic and physical characteristics affect leadership outcomes through the leader's diffuse status. Moreover, we explain how other status types, such as status derived from the leader's position in the organizational hierarchy and status related to task‐relevant leader characteristics, can moderate the effects of the leader's diffuse status. Finally, we discuss the utility of our proposed integrative framework for researchers and practitioners and outline promising future research opportunities.
Factor D
Authors: Sekine Hideharu , Machida Takeshi , Fujita Teizo 
Published: November 2022

SummaryComplement factor D (FD) is a serine protease that plays an essential role in the activation of the alternative pathway (AP) by cleaving complement factor B (FB) and generating the C3 convertases C3(H2O)Bb and C3bBb. FD is produced mainly from adipose tissue and circulates in an activated form. On the contrary, the other serine proteases of the complement system are mainly synthesized in the liver. The activation mechanism of FD has long been unknown. Recently, a serendipitous discovery in the mechanism of FD activation has been provided by a generation of Masp1 gene knockout mice lacking both the serine protease MASP‐1 and its alternative splicing variant MASP‐3, designated MASP‐1/3‐deficient mice. Sera from the MASP‐1/3‐deficient mice had little‐to‐no lectin pathway (LP) and AP activity with circulating zymogen or proenzyme FD (pro‐FD). Sera from patients with 3MC syndrome carrying mutations in the MASP1 gene also had circulating pro‐FD, suggesting that MASP‐1 and/or MASP‐3 are involved in activation of FD. Here, we summarize the current knowledge of the mechanism of FD activation that was finally elucidated using the sera of mice monospecifically deficient for MASP‐1 or MASP‐3. Sera of the MASP‐1‐deficient mice lacked LP activity, but those of the MASP‐3‐deficient mice lacked AP activity with pro‐FD. This review illustrates the pivotal role of MASP‐3 in the physiological activation of the AP via activation of FD.
Swedish translation, cultural adaptation and psychometric evaluation of the pressure ulcer knowledge assessment tool for use in the operating room
Authors: Falk‐Brynhildsen Karin , Raepsaet Charlotte , Wistrand Camilla , Bååth Carina , Leo Swenne Christine , Gifford Mervyn , Gunningberg Lena , von Vogelsang Ann‐Christin , Björn Catrine , Beeckman Dimitri 
Published: November 2022

AbstractThe aim of this study was to psychometrically evaluate the Swedish operating room version of PUKAT 2.0. In total, 284 Swedish operating room nurses completed the survey of whom 50 completed the retest. The item difficulty P‐value of 14 items ranged between 0.38 and 0.96 (median 0.65). Three items were found to be too easy (0.90–0.96). The D‐value of 14 items ranged between 0.00 and 0.42 (median 0.46). Three items had a D‐value lower than 0.20 (0.11–0.16) and eight items scored higher than 0.40 (0.45–0.61). The quality of the response alternatives (a‐value) ranged between 0.00 and 0.42. This showed that nurses with a master's degree had a higher knowledge than nurses with a professional degree (respectively 9.4/14 versus 8.6/14; t = −2.4, df = 199, P = 0.02). The ICC was 0.65 (95% CI 0.45–0.78). The ICCs for the domains varied from 0.12 (95% CI = −0.16–0.39) to 0.59 (95% CI = 0.38–0.75). Results indicated that 11 of the original items contributed to the overall validity. However, the low participation in the test‐retest made the reliability of the instrument low. An extended evaluation with a larger sample should be considered in order to confirm aspects of the psychometric properties of this instrument.
Esophageal temperature management during cryoballoon ablation for atrial fibrillation
Authors: Sink Joshua , Nimmagadda Kiran , Zhao Manyun , Andrei Adin‐Cristian , Gay Hawkins , Kaplan Rachel M. , Gao Xu , Pfenniger Anna , Patil Kaustubha D. , Arora Rishi , Kim Susan S. , Chicos Alexandru B. , Lin Albert C. , Passman Rod S. , Knight Bradley P. , Verma Nishant 
Published: November 2022

AbstractIntroductionEsophageal thermal injury (ETI) is a well‐recognized complication of atrial fibrillation (AF) ablation. Previous studies have demonstrated that direct esophageal cooling reduces ETI during radiofrequency AF ablation. The purpose of this study was to evaluate the use of an esophageal warming device to prevent ETI during cryoballoon ablation (CBA) for AF.MethodsThis prospective, double‐blinded study enrolled 42 patients with symptomatic AF undergoing CBA. Patients were randomized to the treatment group with esophageal warming (42°C) using recirculated water through a multilumen, silicone tube inserted into the esophagus (EnsoETM®; Attune Medical) (WRM) or the control group with a luminal single‐electrode esophageal temperature monitoring probe (LET). Patients underwent upper endoscopy esophagogastroduodenoscopy (EGD) the following day. ETI was classified into four grades.ResultsBaseline patient characteristics were similar between groups. Procedural characteristics including number of freezes, total freeze time, early freeze terminations, coldest balloon temperature, procedure duration, posterior wall ablation, and proton pump inhibitor and transesophageal echocardiogram use before procedure were not different between groups. The EGD was completed in 40/42 patients. There was significantly more ETI in the WRM group compared to the LET group (n = 8 [38%] vs. n = 1 [5%], p = 0.02). All ETI lesions were grade 1 (erythema) or 2 (superficial ulceration). Total freeze time in the left inferior pulmonary vein was predictive of ETI (360 vs. 300 s, p = 0.03).ConclusionUse of a luminal heat exchange tube for esophageal warming during CBA for AF was paradoxically associated with a higher risk of ETI.
Correlation between AV synchrony and device collected AM‐VP sequence counter in atrioventricular synchronous leadless pacemakers: A real‐world assessment
Authors: Garweg Christophe , Piccini Jonathan P. , Epstein Laurence M. , Frazier‐Mills Camille , Chinitz Larry A. , Steinwender Clemens , Stromberg Kurt , Sheldon Todd , Fagan Dedra H. , El‐Chami Mikhael F. 
Published: November 2022

AbstractIntroductionMicra atrioventricular (AV) provides leadless atrioventricular synchronous pacing by sensing atrial contraction (A4 signal). Real‐world operation and reliability of AV synchrony (AVS) assessment using device data have not been described. The purposes of this study were to (1) assess the correlation between AVS and atrial mechanical sensed‐ventricular pacing (AM‐VP) percentages in patients with permanent high‐degree AV block and (2) report on the real‐world effectiveness of Micra AV.MethodsThe correlation between ECG‐determined AVS in‐clinic and device‐collected %AM‐VP was assessed using data from 40 patients with high‐degree AV block enrolled in the Micra Atrial tRacking using a Ventricular AccELerometer (MARVEL) 2 study. A retrospective analysis to assess continuously‐sampled %AM‐VP since last session, device programming, and electrical parameters was performed using Micra AV transmissions from the Medtronic CareLink database. Patients with transmissions ≥180 days postimplant were included.ResultsAmong the 40 MARVEL 2 AV block patients with a median %VP of 99.7%, AVS was highly correlated with AM‐VP (median AVS 87.1%, median AM‐VP 79.1%; R2 = 0.764, p < .001). The CareLink cohort included 4384 patients programmed to VDD mode. The mean A4 amplitude was 2.3 ± 1.8 m/s2 at implant and 2.3 ± 1.6 m/s2 at 28 weeks. In patients with %VP >90% (n = 1662), the median %AM‐VP was 74.7%. For the full cohort, median %VP was 65.6% and median projected battery longevity was 10.5 years.ConclusionIn patients with a high pacing burden, %AM‐VP provides a reasonable estimation of AVS. The first large real‐world analysis of Micra AV patients with >90% VP showed stable atrial sensing over time with a median %AM‐VP, a correlate of AVS, of 74.7%.
SOX10 modulated SMARCA4 dysregulation alleviates DNA replication stress in cutaneous melanoma
Authors: Fang Xiangjian , Rao Keqiang , Wei Zhiyi , Cheng Juntao 
Published: November 2022

AbstractCutaneous melanoma (CM) is the most fatal type of skin cancer with a high potency of metastasis, yet the treatment for metastatic melanoma remains limited. In this study, we are devoted to addressing the prognostic value and underlying mechanism of DNA damage repair‐related genes in CM. We utilized integrated bioinformatic approaches and machine learning models to identify a cluster of convergently expressed DNA damage repair‐related genes in melanoma. With multivariate Cox regression, SMARCA4 (also known as BRG1) was identified as an independent prognostic marker for melanoma patients. Yet the expression of SMARCA4 is not altered with the pathological staging or the metastasis condition. SMARCA4 is an essential ATPase subunit of the mammalian SWI/SNF complex. Mechanistically, we demonstrated that SMARCA4 could resolve DNA replication stress and guarantee the proliferation of melanoma cells. Furthermore, we predicted the binding of different transcription factors on the SMARCA4 promoter and unveiled the modulated expression of SMARCA4 by SOX10 in melanoma. Together, we performed integrated approaches to identify SMARCA4 as a promising prognostic marker for melanoma, which was transcriptionally regulated by SOX10 and promoted melanoma cell proliferation by ameliorating DNA replication stress.
Proximal ear hole injury heals by limited regeneration during the early postnatal phase in mice
Authors: Abarca‐Buis René Fernando , Krötzsch Edgar 
Published: November 2022

AbstractEar pinna is a particular feature of mammals that shows several repair responses depending on age. Two millimeter hole made in the pinna of middle‐aged female mice heals due to partial reconstitution of new tissues (limited regeneration), whereas a hole punched in the ear of young mice forms a scar tissue. In these studies, the injury is made in the center of the ear pinna, but little is known about the type of reparative response along the proximodistal polarity of the ear. This study evaluated the effect of pinna polarity, age, and sex in the ear hole‐repairing response in Balb/c mice. Proximal injuries were repaired more efficiently by limited regeneration than wounds made in the middle region. Non‐injured ear histological analysis revealed a higher presence of muscle, adipose tissue, cartilage, and larger blood vessels in the proximal ear area, which could influence ear hole closure by limited regeneration. To evaluate the healing response during ear growth, we punched a standard hole in the proximal area of the ear on postnatal day 21 and 8‐month‐old mice (adults). Thirty‐five days after the wound, both groups reached the same wound closure, despite the greater proportional size of holes made in the younger mice. Ear growth also improved ear hole closure in male mice. These results suggest that ear growth accelerates hole closure, providing an example of enhanced regenerative abilities in growing structures. Finally, hole closure kinetics in the growing ear indicated an early re‐differentiation phase exhibited at 14 days post‐wound. In conclusion, ear topography and growth positively influenced the healing response to ear holes, making it a tractable model to study in mammals.
Overview of laparoscopic surgery for cervical cancer in Japan: Updates after the laparoscopic approach to cervical cancer trial
Authors: Kobayashi Eiji , Kakuda Mamoru , Ueda Yutaka , Kimura Tadashi 
Published: November 2022

AbstractLaparoscopic radical hysterectomy (LRH) for cervical cancer has been reported to be similar oncologic outcome compared to abdominal radical hysterectomy (ARH) in many retrospective studies. In Japan, LRH has been covered by insurance since April 2018. In 2018, the same year that LRH became covered by insurance, Ramirez et al. at MD Anderson Cancer Center reported the results of a large phase III laparoscopic approach to cervical cancer trial (LACC trial) on the prognosis of open versus laparoscopic/robot‐assisted minimally invasive radical hysterectomy. The results showed that minimally invasive approaches were associated with a higher rate of recurrence and death. At this point, it is not clear what is wrong with LRH and why it has a poorer prognosis compared to ARH. In this report, after the LACC report, we would like to review the current status of minimally invasive surgery for cervical cancer and future directions.
Supporting adjective learning across the curriculum by 5–7 year‐olds: Insights from psychological research
Authors: Davies Catherine , Syrett Kristen , Taylor Lucy , Wilkes Samantha , Zuniga‐Montanez Cecilia 
Published: November 2022

AbstractAdjectives are a powerful tool for enriching vocabulary and developing conceptual understanding. In early elementary and primary classrooms, across core and foundation subjects, children are expected to describe, measure, classify, and compare objects and events—all processes that require a mastery of adjective meanings and use. While teachers are trained in vocabulary learning, they may be less familiar with: (i) the psychological processes by which children learn adjectives, and (ii) how a focus on adjectives can support learning in domains beyond language and literacy lessons. To address these gaps, we have collaborated as a unique interdisciplinary team with linguistic, psychological, and pedagogical expertise. We synthesise research across our disciplines to provide an accessible, practical, evidence‐based primer of research findings on adjective development. We then provide guidance on how these findings can be used to enhance teaching and learning practices across subjects for children aged five to seven.
Snacking habits of Brazilian adolescents: Brazilian National Dietary Survey, 2017–2018
Authors: Monteiro Luana Silva , Rodrigues Paulo Rogério Melo , de Vasconcelos Thaís Meirelles , Sperandio Naiara , Yokoo Edna Massae , Sichieri Rosely , Pereira Rosângela Alves 
Published: November 2022

AbstractThis study was aimed at describing the snack consumption among Brazilian adolescents. The Brazilian National Dietary Survey (2017–2018) is a nationwide representative cross‐sectional study that collected food consumption data from 8264 adolescents (10 to 19 years old); data from one 24‐h recall were used, in which all foods and beverages consumed throughout the day prior to the interview were described along with the amount, unit of measurement, time, place and occasion of consumption (breakfast, lunch, dinner or snack). Snacks were classified as follows: (a) Morning snack: “Snacks” consumed between 6 AM and 12 PM; (b) Afternoon snack: “Snacks” consumed between 1 PM and 5 PM; (c) Evening snack: “Snacks” consumed between 6 PM and 5 AM. Individuals were categorised according to the number of “Snacks” per day (zero, one, two or three or more). Among the evaluated adolescents, 52.8% were female and 23.0% were overweight. The consumption of at least one snack per day was mentioned by 88.2% of the adolescents, with an average of 2.33 snacks per day. An afternoon snack was consumed by 70.0% of the adolescents. Snack consumption was related to higher mean daily energy intake and a greater contribution of carbohydrates, added sugar and trans fat to the total daily energy intake. ‘Cookies & Crackers’ and ‘Fast Foods’ were the groups that contributed the most to the energy intake provided by snacks, showing, therefore, that less healthy foods were relevant components of the snacks consumed. For their important contribution to food intake, snacking habits deserve attention among the topics covered in dietary guidelines.
Is breakfast consumption among Brazilian schoolchildren associated with an ultra‐processed food dietary pattern?
Authors: Belchor Ana Luisa Lages , de Assis Maria Alice Altenburg , Cezimbra Vanessa Guimarães , Pereira Luciana Jeremias , Roberto Denise Miguel Teixeira , Giacomelli Simone de Castro , Vieira Francilene Gracieli Kunradi , Di Pietro Patrícia Faria , Hinnig Patrícia de Fragas 
Published: November 2022

AbstractOmission of breakfast starts at school age and can be explained as a reflection of the independent behaviour acquired in this phase of life. Breakfast has been investigated for its association with healthier diet quality, but few studies have investigated this relationship in schoolchildren aged 7 to 13 years. The objective of this study was to assess breakfast consumption in schoolchildren aged 7 to 13 years and to examine associations with dietary patterns (DPs). It was a cross‐sectional study carried out in 2017 with 1069 students in Florianopolis, southern Brazil. Previous‐day food consumption, physical activity and screen activities were self‐reported. Factor analysis was used to identify DPs. Associations between breakfast consumption and overall DPs were evaluated using multivariate linear regression. Breakfast consumption was reported by 85% of the children, with the highest proportion observed among students on the afternoon school shift. Five DPs were identified explaining 41% of the total variance in daily food consumption: Ultra‐processed, Mixed, Traditional Brazilian Lunch, Healthy + Sweets and Traditional Brazilian Breakfast. Breakfast consumption was directly associated with a Traditional Brazilian Breakfast DP (β = 0.335; 95% CI = 0.227, 0.442), a Mixed DP (β = 0.241; 95% CI = 0.160, 0.323), and a Healthy + Sweets DP (β = 0.160; 95% CI = 0.061, 0.260), and inversely associated with an Ultra‐processed DP (β = −0.116; 95% CI = −0.207, −0.026). Breakfast consumption was associated with overall DPs, suggesting the importance of eating this meal by schoolchildren. We emphasise the relevance of offering a healthy breakfast at public schools for students who do not take this meal at home, contributing to health promotion.
Finding a mission in bureaucracies: How authentic leadership and red tape interact
Authors: Vogel Rick , Vogel Dominik , Reuber Artur 
Published: November 2022

AbstractFinding a mission is important for employees to perform well in public service jobs. Research has demonstrated that leadership can facilitate mission valence among followers, but if and how leadership unfolds this effect in the presence of excessive bureaucracy (i.e., red tape) is unclear. This interaction is particularly interesting in the case of authentic leadership (i.e., a positive leadership style based on self‐awareness, consistent behaviors, and transparent relations with followers), as red tape may either neutralize or enhance the association of authentic leadership with mission valence. We test these rivalry hypotheses in a sample from a two‐wave survey among public employees in Germany. Results provide support for the neutralization hypothesis, as the relationship between authentic leadership and mission valence strengthens at lower levels of red tape. HR practitioners are thus challenged to reduce red tape and to make public organizations authentic places, where leaders can develop authenticity through self‐awareness.
Challenges when going on excursions with children with medical complexity in Japan
Authors: Kosaka Makoto , Murata Nanami , Kaneda Yudai , Kotera Yasuhiro , Sagara Soma , Masunaga Hidehisa , Miyatake Hirotomo , Nishikawa Yoshitaka , Komori Naomi , Ozaki Akihiko , Beniya Hiroyuki 
Published: November 2022

AbstractBackgroundWith advances in medical technology, the number of children with medical complexity (CMC) has increased. Excursions with such children encourage their social participation and have been shown to have a positive impact on their caregivers. However, the first‐hand experience of the excursions has not yet been evaluated regarding the difficulties faced by CMC and their caregivers during preparation, transportation, and in the local area.MethodsSemi‐structured interviews were conducted with eight informal and eight formal caregivers of CMC who attended an excursion to Tokyo Disney Land (TDL) via video conference. We investigated challenges that they had experienced through the excursion, performing inductive thematic analysis.ResultsThree themes were identified: the preparation stage (Theme 1), problems encountered while traveling to the theme park (Theme 2), and problems at the theme park (Theme 3). In the preparation stage, three subthemes, i.e. preparation for the trip, cooperation with related parties, and researching about the theme park and asking for help, are reported. Theme 2 includes four subthemes: activities of daily living, respiratory care, luggage, and weather changes. Theme 3 has three subthemes: activities of daily living, physical condition management, and issues for the theme parks.ConclusionsWe found that securing the power supply, location, and time for daily procedures are challenges in realizing excursions for CMC, but with sufficient preparation, it is possible in Japan without major difficulty.
Transforming STEM outcomes: Results from a seven‐year follow‐up study of an after‐school robotics program's impacts on freshman students
Authors: Meschede Tatjana , Haque Zora , Warfield Marji Erickson , Melchior Alan , Burack Cathy , Hoover Matthew 
Published: November 2022

AbstractOver the past two decades, educators and policymakers have expressed growing concerns over the low levels of math and science achievement among American students and the gradual decline in the numbers of young people moving into science, technology, engineering, and math (STEM) careers. While interest in expanding the numbers of young people moving into science and technology fields has grown, a relatively small proportion of STEM education research has focused on the role that after‐school programs can play to reinforce STEM learning and help engage young people in educational pathways leading to STEM careers. This study examines the impacts of FIRST, an after‐school robotics program, upon students' interests in STEM, as well as the likelihood for participants to pursue STEM in their academic and professional careers. Data were collected in a 7‐year follow‐up study of intervention group participants and a matched comparison group. We find that FIRST college students reported significantly higher rates of STEM interests, attitudes, and college level behaviors than comparison students. These findings have implications for the role of after‐school programming in STEM education involving hands‐on learning experiences in science‐ and technology‐related fields, when considering young people's decision‐making regarding their STEM college and career choices.