bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actors in forums: work input and different types of benefits
Authors: Fischer Manuel , Maag Simon 
Published: June 2022

AbstractForums provide venues where different actors from the public administration sector, the interest group sector, or the research sector jointly discuss an issue of common interest. This article analyses which types of benefits are related to actors’ investing working time to forums. Actors’ dedication and work are basic predicates for forums to be able to produce outputs. The analysis of members of eight forums dealing with habitat and natural hazard governance in Switzerland suggests that actors participating in forums attribute more importance to exchange benefits, corresponding to opportunities of interaction with other actors – than to policy benefits – corresponding to opportunities for actors to influence policy or practice. However, more working time is invested by actors that lend importance to individual benefits – as opposed to collective benefits. These findings are important for understanding why actors provide work for forums in collaborative and polycentric governance systems.
Successful retrieval of embolised Occlutech atrial septal defect occluder from descending aorta in a 4-year-old child using a “mother and child” technique: a case report and literature review
Authors: Salam Abdul , Yates Robert , Khambadkone Sachin 
Published: June 2022

AbstractA 9 mm Occlutech septal occluder Flex II device was retrieved in a 4-year-old 22 kg child; A 6 Fr Cook® Flexor sheath (child) was inserted into a 9 Fr Occlutech® ASD Delivery Set (mother). Once the tip of the smaller sheath was close to the device, a 4 Fr right Judkins catheter was introduced with a snare. The right atrial hub was captured and withdrawn to the level of the 6 Fr sheath which was then withdrawn into the 9 Fr sheath before being removed completely. The “mother and child” technique offers a greater likelihood of slenderising and retrieving embolised devices.
Why Is Right-Wing Media Consumption Associated With Lower Compliance	With COVID-19 Measures?
Authors: Ponizovskiy Vladimir , Grigoryan Lusine , Hofmann Wilhelm 
Published: June 2022

Abstract. Exposure to right-wing media has been shown to be related to lower perceived threat from COVID-19, lower compliance with prophylactic measures against it, and higher incidence of infection and death. What features of right-wing media messages may account for these effects? In a preregistered cross-sectional study ( N = 554), we tested a model that differentiates perceived consequences of two CDC (Centers for Disease Control and Prevention) recommendations – washing hands and staying home – for basic human values. People who consumed more right-wing media perceived these behaviors as less beneficial for their personal security, for the well-being of close ones, and the well-being of society at large. Perceived consequences of following the CDC recommendations mediated the relationship between media consumption and compliance with recommendations. Implications for public health messaging are discussed.
Sustained effects of single doses of classical psychedelics in humans
Authors: Knudsen Gitte M. 
Published: June 2022

AbstractThe serotonergic classical psychedelics include compounds that primarily activate the brain’s serotonin 2 A receptor (5-HT2AR), such as LSD, psilocybin, and DMT (ayahuasca). The acute effects of these compounds are well-known as are their ability to increase the emotional state both in healthy people and in those with neuropsychiatric disorders. In particular psilocybin, the psychoactive constituent in “magic mushrooms”, has shown great potential for treatment of anxiety and depression. A unique and compelling feature of psychedelics is that intake of just a single psychedelic dose is associated with long-lasting effects. This includes effects on personality, e.g., higher openness, and amelioration of depressive symptoms. This review focuses on these stunning effects and summarizes our current knowledge on which behavioral, biochemical, neuroimaging, and electrophysiological data support that the intriguing effects of psychedelics on the human brain and mind are based on neural plasticity. The review also points to so far understudied areas and suggests research questions to be addressed in future studies which potentially can help to understand the intriguing long-term effects after intake of a single (or a few) psychedelic doses.
Strong, tough, ionic conductive, and freezing-tolerant all-natural hydrogel enabled by cellulose-bentonite coordination interactions
Authors: Wang Siheng , Yu Le , Wang Shanshan , Zhang Lei , Chen Lu , Xu Xu , Song Zhanqian , Liu He , Chen Chaoji 
Published: June 2022

AbstractIonic conductive hydrogels prepared from naturally abundant cellulose are ideal candidates for constructing flexible electronics from the perspective of commercialization and environmental sustainability. However, cellulosic hydrogels featuring both high mechanical strength and ionic conductivity remain extremely challenging to achieve because the ionic charge carriers tend to destroy the hydrogen-bonding network among cellulose. Here we propose a supramolecular engineering strategy to boost the mechanical performance and ionic conductivity of cellulosic hydrogels by incorporating bentonite (BT) via the strong cellulose-BT coordination interaction and the ion regulation capability of the nanoconfined cellulose-BT intercalated nanostructure. A strong (compressive strength up to 3.2 MPa), tough (fracture energy up to 0.45 MJ m−3), yet highly ionic conductive and freezing tolerant (high ionic conductivities of 89.9 and 25.8 mS cm−1 at 25 and −20 °C, respectively) all-natural cellulose-BT hydrogel is successfully realized. These findings open up new perspectives for the design of cellulosic hydrogels and beyond.
Islet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes
Authors: Zhang Li , Jonscher Karen R. , Zhang Zuyuan , Xiong Yi , Mueller Ryan S. , Friedman Jacob E. , Pan Chongle 
Published: June 2022

AbstractThe immune system of some genetically susceptible children can be triggered by certain environmental factors to produce islet autoantibodies (IA) against pancreatic β cells, which greatly increases their risk for Type-1 diabetes. An environmental factor under active investigation is the gut microbiome due to its important role in immune system education. Here, we study gut metagenomes that arede-novo-assembled in 887 at-risk children in the Environmental Determinants of Diabetes in the Young (TEDDY) project. Our results reveal a small set of core protein families, present in >50% of the subjects, which account for 64% of the sequencing reads. Time-series binning generates 21,536 high-quality metagenome-assembled genomes (MAGs) from 883 species, including 176 species that hitherto have no MAG representation in previous comprehensive human microbiome surveys. IA seroconversion is positively associated with 2373 MAGs and negatively with 1549 MAGs. Comparative genomics analysis identifies lipopolysaccharides biosynthesis inBacteroidesMAGs and sulfate reduction inAnaerostipesMAGs as functional signatures of MAGs with positive IA-association. The functional signatures in the MAGs with negative IA-association include carbohydrate degradation in lactic acid bacteria MAGs and nitrate reduction inEscherichiaMAGs. Overall, our results show a distinct set of gut microorganisms associated with IA seroconversion and uncovered the functional genomics signatures of these IA-associated microorganisms
A trefoil knot self-templated through imination in water
Authors: Lei Ye , Li Zhaoyong , Wu Guangcheng , Zhang Lijie , Tong Lu , Tong Tianyi , Chen Qiong , Wang Lingxiang , Ge Chenqi , Wei Yuxi , Pan Yuanjiang , Sue Andrew C.-H. , Wang Linjun , Huang Feihe , Li Hao 
Published: June 2022

AbstractThe preparation of topologically nontrivial molecules is often assisted by covalent, supramolecular or coordinative templates that provide spatial pre-organization for all components. Herein, we report a trefoil knot that can be self-assembled efficiently in water without involving additional templates. The direct condensation of three equivalents of a tetraformyl precursor and six equivalents of a chiral diamine produces successfully a [3 + 6] trefoil knot whose intrinsic handedness is dictated by the stereochemical configuration of the diamine linkers. Contrary to the conventional wisdom that imine condensation is not amenable to use in water, the multivalent cooperativity between all the imine bonds within the framework makes this trefoil knot robust in the aqueous environment. Furthermore, the presence of water is proven to be essential for the trefoil knot formation. A topologically trivial macrocycle composed of two tetraformyl and four diamino building blocks is obtained when a similar reaction is performed in organic media, indicating that hydrophobic effect is a major driving force behind the scene.
Suspension printing of liquid metal in yield-stress fluid for resilient 3D constructs with electromagnetic functions
Authors: Wu Qian , Zhu Fengbo , Wu Ziliang , Xie Yu , Qian Jin , Yin Jun , Yang Huayong 
Published: June 2022

AbstractLiquid metal is an ideal conductive material for soft electronics because of its high conductivity and fluidity at room temperature. However, the large surface tension and high mass density of liquid metal make forming three-dimensional (3D) dangling structures a challenging task. Reported here is a suspension printing strategy for direct deposition of galinstan-based liquid metal into 3D dangling structures with high shape fidelity and spatial resolution (~150 μm). Acrylamide/nanoclay suspension served as a yield-stress fluid support bath, with selected hydrogen peroxide to immediately oxidize the gallium skin and strengthen the extruded liquid metal, thus continuous liquid metal filaments were deposited successfully. The subsequent photo-curing of acrylamide/nanoclay works as a resilient outer packaging, giving rise to a ~500% tensile deformation for liquid metal-hydrogel composite. This suspension printing strategy should broaden the opportunity of using 3D and functional liquid metal constructs for soft yet resilient electromagnetic devices.
COVID-19 associated mucormycosis in Assiut University Hospitals: a multidisciplinary dilemma
Authors: Farghly Youssif Sahar , Abdelrady Marwa M. , Thabet Ahmed Atef , Abdelhamed Mohamed A. , Gad Mohamed Omar A. , Abu-Elfatth Ahmed Mohmmed , Saied Ghada Mohamed , Goda Islam , Algammal Abdelazeem M. , Batiha Gaber El-Saber , Abd el-Rady Nessren M. , Hetta Helal F. , Kasem Soheir M. 
Published: June 2022

AbstractMucormycosis is a life-threatening opportunistic angioinvasive fungal infection. We aimed to describe the frequency, presentations, predictors, and in-hospital outcome of mucormycosis patients in the scope of CoronaVirusDisease-19 (COVID-19) during the third viral pandemic wave. This cross-sectional retrospective study included all patients who fulfilled the criteria of mucormycosis with concurrent confirmed covid19 infection admitted to Assuit University Hospital between March 2021 and July 2021. Overall, 433 patients with definite covid-19 infection, of which 33 (7.63%) participants were infected with mucormycosis. Mucormycosis was predominantly seen in males (21 vs. 12; p = 0.01). Diabetes mellitus (35% vs. 63.6%; p < 0.001), hypertension (2% vs.45.5%; p 0.04), and Smoking (26.5% vs. 54.5%; p < 0.001) were all significantly higher in mucormycosis patients. Inflammatory markers, especially E.S.R., were significantly higher in those with mucormycosis (p < 0.001). The dose of steroid intake was significantly higher among patients with mucormycosis (160 mg vs. 40 mg; p < 0.001). Except for only three patients alive by residual infection, 30 patients died. The majority (62%) of patients without mucormycosis were alive. Male sex; Steroid misuse; D.M.; Sustained inflammation; Severe infection were significant risk factors for mucormycosis by univariate analysis; however, D.M.; smoking and raised E.S.R. were predictors for attaining mucormycosis by multivariate analysis.
Urinary extracellular vesicles and micro-RNA as markers of acute kidney injury after cardiac surgery
Authors: Miller Douglas , Eagle-Hemming Bryony , Sheikh Sophia , Joel-David Lathishia , Adebayo Adewale , Lai Florence Y. , Roman Marius , Kumar Tracy , Aujla Hardeep , Murphy Gavin J. , Woźniak Marcin J. 
Published: June 2022

AbstractWe hypothesised that measuring changes in urinary levels of EV and miR will predict the onset of acute kidney injury in cardiac surgery patients. The study was performed in the cohort of the REVAKI-2 trial. Urine samples were collected before and 24 h after the procedure from 94 cardiac surgery patients. Urinary particle concentrations and size distribution were assessed using NanoSight. EV derivation and levels were measured using flow cytometry. Samples from 10 selected patients were sequenced, and verification was performed with advanced TaqMan assays in samples from all patients. Urinary particle concentrations significantly increased in patients with AKI after surgery, with the percentage of EV positive for CD105 and β1-integrin also increasing. Pre-surgery podocalyxin-positive EV were significantly lower in patients with AKI. Their levels correlated with the severity of the injury. Pre-operative miR-125a-5p was expressed at lower levels in urine from patients with AKI when adjusted for urinary creatinine. Levels of miR-10a-5p were lower after surgery in AKI patients and its levels correlated with the severity of the injury. Pre-operative levels of podocalyxin EVs, urinary particle concentrations and miR-125a-5p had moderate AKI predictive value and, in a logistic model together with ICU lactate levels, offered good (AUC = 82%) AKI prediction.
Deep imagination is a close to optimal policy for planning in large decision trees under limited resources
Authors: Mastrogiuseppe Chiara , Moreno-Bote Rubén 
Published: June 2022

AbstractMany decisions involve choosing an uncertain course of action in deep and wide decision trees, as when we plan to visit an exotic country for vacation. In these cases, exhaustive search for the best sequence of actions is not tractable due to the large number of possibilities and limited time or computational resources available to make the decision. Therefore, planning agents need to balance breadth—considering many actions in the first few tree levels—and depth—considering many levels but few actions in each of them—to allocate optimally their finite search capacity. We provide efficient analytical solutions and numerical analysis to the problem of allocating finite sampling capacity in one shot to infinitely large decision trees, both in the time discounted and undiscounted cases. We find that in general the optimal policy is to allocate few samples per level so that deep levels can be reached, thus favoring depth over breadth search. In contrast, in poor environments and at low capacity, it is best to broadly sample branches at the cost of not sampling deeply, although this policy is marginally better than deep allocations. Our results can provide a theoretical foundation for why human reasoning is pervaded by imagination-based processes.
Microstructure effects on the phase transition behavior of a prototypical quantum material
Authors: Schunck Jan O. , Döring Florian , Rösner Benedikt , Buck Jens , Engel Robin Y. , Miedema Piter S. , Mahatha Sanjoy K. , Hoesch Moritz , Petraru Adrian , Kohlstedt Hermann , Schüßler-Langeheine Christian , Rossnagel Kai , David Christian , Beye Martin 
Published: June 2022

AbstractMaterials with insulator-metal transitions promise advanced functionalities for future information technology. Patterning on the microscale is key for miniaturized functional devices, but material properties may vary spatially across microstructures. Characterization of these miniaturized devices requires electronic structure probes with sufficient spatial resolution to understand the influence of structure size and shape on functional properties. The present study demonstrates the use of imaging soft X-ray absorption spectroscopy with a spatial resolution better than 2 $$\upmu$$
μ
m to study the insulator-metal transition in vanadium dioxide thin-film microstructures. This novel technique reveals that the transition temperature for the conversion from insulating to metallic vanadium dioxide is lowered by 1.2 K ± 0.4 K close to the structure edges compared to the center. Facilitated strain release during the phase transition is discussed as origin of the observed behavior. The experimental approach enables a detailed understanding of how the electronic properties of quantum materials depend on their patterning at the micrometer scale.
Phase memory of optical vortex beams
Authors: Eshaghi Mahdi , Acevedo Cristian Hernando , Batarseh Mahed , Guzman-Sepulveda José Rafael , Dogariu Aristide 
Published: June 2022

AbstractOptical vortex beams are under considerable scrutiny due to their demonstrated potential for applications ranging from quantum optics to optical communications and from material processing to particle trapping. However, upon interaction with inhomogeneous material systems, their deterministic properties are altered. The way these structured beams are affected by different levels of disturbances is critical for their uses. Here, for the first time, we quantify the degradation of perfect optical vortex beams after their interaction with localized random media. We developed an analytical model that (1) describes how the spatial correlation and the phase variance of disturbance affect the phase distribution across the vortex beams and (2) establishes the regimes of randomness for which the beams maintain the memory of their initial vorticity. Systematic numerical simulations and controlled experiments demonstrate the extent of this memory effect for beams with different vorticity indices.
NMDA receptor inhibition prevents intracellular sodium elevations in human olfactory neuroepithelial precursors derived from bipolar patients
Authors: Gao Yonglin , Mack Aaron A. , Litteral Carleigh , Delamere Nicholas A. , El-Mallakh Rif S. 
Published: June 2022

AbstractDysregulation of ion flux across membranes and glutamate-induced excitotoxicity appear to be important pathophysiologic abnormalities in bipolar illness. Understanding ion control and responses to ionic stress is important to decipher the pathogenesis of this disorder. Monensin alone significantly increased [Na]i in ONPs from bipolar individuals (5.08 ± 0.71 vs baseline 3.13 ± 0.93, P = 0.03) and AP5 had no effect (2.0 ± 1.2 vs baseline 3.13 ± 0.93, P = 0.27). However, the combination of AP5 and monensin resulted in normalization of [Na]i (3.25 ± 1.28 vs baseline 3.13 ± 0.93, P = 0.89). This effect was not observed in cells from non-bipolar individuals (monensin alone, 1.72 ± 1.10 vs baseline 2.42 ± 1.80, P = 0.25; AP5 alone, 1.37 ± 0.74 vs baseline 2.42 ± 1.80; AP5 combined with monensin, 1.53 ± 0.98 vs baseline 2.42 ± 1.80, P = 0.31). Sodium regulation is central to neuronal function and may be disturbed in patients with bipolar disorder. Monensin is an ionophore, meaning that it incorporates itself into the membrane and allows sodium to enter independent of cellular membrane proteins. While the mechanism remains obscure, the observation that the NMDA receptor antagonist, AP5, normalizes [Na]i only in olfactory neuroepithelial precursors obtained from bipolar illness may provide novel insights into ion regulation in tissues from subjects with bipolar illness.
Efficient terminal erythroid differentiation requires the APC/C cofactor Cdh1 to limit replicative stress in erythroblasts
Authors: Cuadrado Myriam , Garzón Javier , Moreno Sergio , García-Higuera Irene 
Published: June 2022

AbstractThe APC/C-Cdh1 ubiquitin ligase complex drives proteosomal degradation of cell cycle regulators and other cellular proteins during the G1 phase of the cycle. The complex serves as an important modulator of the G1/S transition and prevents premature entry into S phase, genomic instability, and tumor development. Additionally, mounting evidence supports a role for this complex in cell differentiation, but its relevance in erythropoiesis has not been addressed so far. Here we show, using mouse models of Cdh1 deletion, that APC/C-Cdh1 activity is required for efficient terminal erythroid differentiation during fetal development as well as postnatally. Consistently, Cdh1 ablation leads to mild but persistent anemia from birth to adulthood. Interestingly, loss of Cdh1 seems to affect both, steady-state and stress erythropoiesis. Detailed analysis of Cdh1-deficient erythroid populations revealed accumulation of DNA damage in maturing erythroblasts and signs of delayed G2/M transition. Moreover, through direct assessment of replication dynamics in fetal liver cells, we uncovered slow fork movement and increased origin usage in the absence of Cdh1, strongly suggesting replicative stress to be the underlying cause of DNA lesions and cell cycle delays in erythroblasts devoid of Cdh1. In turn, these alterations would restrain full maturation of erythroblasts into reticulocytes and reduce the output of functional erythrocytes, leading to anemia. Our results further highlight the relevance of APC/C-Cdh1 activity for terminal differentiation and underscore the need for precise control of replication dynamics for efficient supply of red blood cells.
Anti-HER2 scFv-CCL19-IL7 recombinant protein inhibited gastric tumor growth in vivo
Authors: Zhang Haiqiang , Ye Xueshuai , Wen Junye , Cai Ziqi , Li Yang , Zhang Mengya , Shen Li , Cai Jianhui 
Published: June 2022

AbstractHER-2 targeted therapies, such as monoclonal antibodies (mAbs) and CAR-T cell therapy have been applied in the treatment of various of cancers. However, the anti-HER2 CAR-T cell therapy are limited by its expensive production procedure and fatal side effects such as cytokine storm or “On target, off tumor”. The application of anti-HER2 mAbs to the soild tumor are also plagued by the patients resistant with different mechanisms. Thus, the recombinant protein technology can be presented as an attractive methods in advantage its less toxic and lower cost. In this study, we produced a HER-2-targeting recombinant protein, which is the fusion of the anti-HER-2 single chain fragment variable domain, CCL19 and IL7 (HCI fusion protein). Our results showed that the recombinant protein can induce the specific lysis effects of immune cells on HER-2-positive gastric tumor cells and can suppress gastric tumor growth in a xenograft model by chemotactic autoimmune cell infiltration into tumor tissues and activated T cells. Taken together, our results revealed that the HCI fusion protein can be applied as a subsequent clinical drug in treating HER-2 positive gastric tumors.