bluuebunny/crossref_metadata_2025_split huggingface dataset:
Destination left ventricular assist devices in island states: asking too much or the inevitable solution
Authors: Vinck Eric E. , Vervoort Dominique , Tiwari Kaushal K. , Kilic Ahmet , Smood Benjamin F. , Rendón Juan C. , Escobar José J. , Gómez Alejandro Quintero , Palmen Meindert , Klautz Robert J. M. 
Published: January 2022

Abstract
Background
Destination left ventricular assist device placement is increasing as a result of donor shortages and changing patient attitudes. As organ shortages become critical, LVAD programs become fundamental even in more remote regions of the world including island states. Here, we provide a look into the current state and availability of LVAD programs in island states.

Main body
A narrative review was performed using the World Health Organization Global Index Medicus and PubMed/MEDLINE databases to identify articles describing the island states having reported LVAD placements and programs. Additionally, INTERMACS reports were used. Data were retrieved and a review is presented describing the current state of LVADs in island states. The Caribbean region as a whole has a heart failure (HF) prevalence of 814 per 100,000 and Oceania 667 per 100,000 people. We estimate that over 3000 people in these islands need either a heart transplant or an LVAD.

Short conclusion
For HF patients living in island regions, special attention should be paid to the inability of having access to specialized mainland medical care. The continuous quest for a solution to HF in island regions should include the establishing of high-quality LVAD programs in a transfer-network centralized/regionalized system to care for those patients not candidates for long-distance air-bridging.
A fetus excised from the small intestinal mesentery of a neonate (fetus in fetu): a case report
Authors: Alekrashy Mohammad Ahmad , Khodary Ahmed Refaat , Alnemr Amr Abd Almohsen , Elsammak Ahmed A. , Elgebaly Sherief M. 
Published: January 2022

Abstract
Background
Fetus in fetu is a rare congenital anomaly. Its incidence is 1/500,000 births. So, pediatric surgeons may encounter this pathology only once or twice during their professional careers.

Case presentation
We present a rare case of a fetus extracted from the small intestinal mesentery of a healthy neonate who was explored after delivery. The extracted fetal mass included a fully differentiated skull and limbs with a celomic cavity. The fetal mass was supplied by a main feeding vessel branching from the superior mesenteric artery.

Conclusion
Fetus in fetu, despite being a rare variant, must be kept in mind when dealing with a neonatal abdominal mass showing bony parts on radiography.
Surgical Reduction of Chronic Bilateral Traumatic Dislocation of the Mandibular Condyles With Erosion of the Middle Fossa Floor: Case Report With Surgical Video
Authors: Agnoletto Guilherme J. , Couldwell Sandrine , Halpern Leslie R. , Adams David R. , Couldwell William T. 
Published: January 2022

BACKGROUND:
Dislocation of the mandibular condyle (MC) is not a common condition, but when a traumatic case involves erosion of the middle fossa floor, it becomes a much more complicated and even rarer pathology.

OBJECTIVE:
To describe the management of traumatic dislocation of the MCs with erosion of the middle fossa floor. We provide a step-by-step surgical video demonstrating reestablishment of the condylar position and occlusion.

METHODS:
A 65-yr-old woman with rheumatoid arthritis presented after a ground-level fall. She was admitted to the intensive care unit with simultaneous complex medical conditions, intubated, and medically treated for over a month. She was seen in outpatient follow-up 2 mo later and noted to have an anterior open bite and bilateral temporomandibular joint pain. Computed tomography of the face showed bilateral dislocation of the MCs with erosion of the middle fossa floor.

RESULTS:
Open surgical treatment with bilateral eminectomies was performed to obtain adequate reduction, involving a multidisciplinary team including neurosurgery, oral–maxillofacial surgery, and otolaryngological surgery. She did well postoperatively.

CONCLUSION:
Multiple factors predispose a patient to MC dislocation, but we believe the catalyst in this case was significant manipulation of the jaw during endotracheal intubation. A chronic postoperative open bite can lead to much more difficult treatment, given bony erosion and fibrotic tissue formation. This case highlights the challenges of diagnosis and treatment of a bilateral traumatic dislocation and provides a surgical video reference description of repair and resolution.
Condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs under the condition of immobilization stress
Authors: Kryvko Yurij , Soguiko Yurij , Hot Iryna , Antonenko Yuliia , Baida Mariana , Kovalska Marta 
Published: January 2022

We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’ lungs under the conditions of immobilization stress. The experiment was conducted on 40 female guinea pigs weighing 0.18-0.20 kg. The animals were divided into 4 groups, each contained 10 guinea pigs: I – intact guinea pigs (control), II–guinea pigs with model of IS on1st day of experiment;Ш–animals on 2nd day of experiment;IV- group of animals on 34th day of experimental model of IS.
The results of our experimental work showed a significant accumulation of lipid peroxidation products in the lung`s tissure in different periods (on 1st, 2nd and 34th days) of immobilization stress. The state of antioxidant defence was characterized by moderate decrease of inzymes activity (superoxide dismutase, catalase and ceruloplasmin). disorders of balance between pro-oxidant and antioxidant systems couse oxidative stress development.
Violation in the axis of the "microbiota of the digestive tract-brain" under conditions of ischemia-reperfusion of the brain (literature review)
Authors: Tkachuk O. , Tkachuk S. , Povar M. , Denysenko O. , Shtefaniuk V. 
Published: January 2022

The aim of the study is to analyze current views concerning interrelations between the state of intestinal microbiota and the course of ischemic-reperfusion brain injury.
Conclusion. Literary data are indicative of disputable scientific opinions existing nowadays concerning the role of dysbacteriosis (neuroprotective or neurodegenerative) in the course of ischemic brain injuries. Meanwhile, the studies are in common concerning the evidenced role of the intestinal microbiota in disturbances of T-cell homeostasis, ratio changes of their Treg-Th17 subpopulations, and migration of intestinal lymphocytes to the ischemic brain.
Cystic Fibrosis - Related Diabetes
Authors: Makuch Marcin , Makuch Marcelina 
Published: January 2022

Cystic fibrosis (CF) is life-shortening autosomal recessive disease, caused by mutations in the cystic fibrosis transmembrane conductance regulator protein. The most common of CF complications is cystic fibrosis-related diabetes (CFRD). The pathophysiology of CFRD is complex. The best test for screening and diagnosis of CFRD is the oral glucose tolerance test (OGTT). Insulin therapy is a treatment of choice in CFDR pharmacotherapy. An inseparable element of CFRD therapy is also physical activity and diet.
The impact of some morphological and motor characteristics in short distance running
Authors: Ramabaja Q. , Rashiti N. , Shkodra M. , Ramadani L. 
Published: January 2022

The knowledge of morphological development and their impact on motor skills in short-distance athletes should be one of the main concerns of athletics coaches, because any scientific research in the field of physical culture and sports is about proving the development and evaluation of anthropological characteristics which are responsible for achieving success in athletics. The purpose of this paper is to confirm the impact of some anthropometric characteristics in the execution of running speeds on short distances, specifically in running at 100, 200 and 400 meters to students aged 18 ± 6 years of the Faculty of Physical Education and Sports in Prishtina. The sample of this research has included a total of 60 students aged 18 years of the Faculty of Physical Education and Sports in Prishtina. The measurements were executed during September in the hall of the Faculty, while the 100, 200, and 400 meter runs in the stadium "Fadil Vokrri" Prishtina. The only condition that was used during the determination of the sample was: that the students are involved in regular physical education classes (and on the day of the measurement be healthy, without the flu, cold or other symptoms). The variables which are applied in this research have been 8 anthropometric variables and 3 motor-specific variables. The results obtained after their processing indicate that the impact of anthropometric variables is higher in running at 100, 200 and 400 meters. Short distance running and long distance running reduces the impact of anthropometric parameters whereas the influence of metabolic factors of energy production is increased. These results were also confirmed using regression analysis, so that groups of predictors of anthropometric characteristics, specific motor skills that statistically significantly influenced each variable of individual criteria. The world records below the 10-second limit, in the 100 m, near the 9-meter limit, show not only the high level of sports, but also the strong impact on the growth, especially of strength indicators, speed-strength, explosive force, as main and applied motor skills in sports and athlete’s everyday life.
Evalution of the effect of obesity-associated inflammation on the response to complex therapy in hypertensive elderly patients with coronary artery disease
Authors: Tofan N. , Tykhonova S. , Iablonska V. , Khyzhnyak O. 
Published: January 2022

Object: to identify factors that limit the effectiveness of pharmacotherapy of hypertension (HT) with comorbid coronary artery disease (CAD) in elderly obese patients by determining laboratory and spectroscopy features related to inflammation. Material and methods: 60 patients (68.2 ± 5.9 y.o.) were observed and treated in Internal Medicine Department of University Clinic of Odessa National Medical University. Patients were divided into 2 groups. The 1st group included patients (n = 30) with body mass index (BMI) ≤25 kg/m2, HT and co-morbid CAD; the 2nd group (n = 30) - patients with BMI≥30 kg/m2, HT and with co-morbid CAD. For each patient’s group antihypertensive combination of Lisinopril and Bisoprolol was prescribed. The Laser correlation spectroscopy (LCS) was a special method for investigation. Results: before pharmacotherapy (PT) in both groups according to LCS 11-150 nm particles are prevailing. But in obese patients 75th percentile of 31-70 nm particles exceeds that one in non-obese group (56.7% vs 30.5%). During PT systolic blood pressure (SBP) value normalized in the patients of 1st group (without obesity), while in the obese patients (2nd group) SBP remained above target level. Creatinine level increased in patients of 1st group (without obesity) by 16.5 μmol / L (p <0.05) with a decrease in GFR by 17.1 ml/min/1.73 m2 (P <0.05). LCS data during PT show increase of 11-30 nm and decrease of 75-150 nm particles in non-obese patients, while in obese patients 71-150 nm particles are prevailing and 150 nm particles have appeared (p<0.05). Conclusions: 1. In elderly hypertensive patients with concomitant CAD, obesity is a factor limiting the effectiveness of complex antihypertensive therapy. 2. An increase of proportion of allergic-directed and appearance of autoimmune-directed homeostatic shifts in serum according to LCS are associated with a decrease of antihypertensive therapy efficacy in elderly hypertensive patients with CAD and obesity. 3. In hypertensive non-obese patients with CAD under the influence of complex antihypertensive therapy deteriorating of renal function is observed while in obesity renal function is not changed. 4. Homeostatic changes revealed in the second group by LCS values probably reflect manifestation of low grade inflammatory process caused by excessive activity of adipose tissue.
Sonography and multislice contrast tomography in the diagnosis of chronic venous insufficiency complicated by trophic ulcers
Authors: Kolomiets O. 
Published: January 2022

Sonography has become the gold standard in the diagnosis of pathological changes in venous insufficiency, however, studies by other scientists indicate the need for a comprehensive study using phlebographic methods.
The aim of the work was to compare the results of sonography and multislice tomography in the diagnosis of chronic venous insufficiency complicated by trophic ulcers.
Materials and methods. The results of treatment of 97 patients with chronic venous insufficiency in stage C6 and C6r were evaluated. Ultrasound angioscanning of the venous system of the lower extremities at the planning stage of surgical treatment and in the postoperative period (early and after a year of observation) was performed on a digital device of expert class for cardiovascular studies (Toshiba Aplio 500) with 5-10 MHz sensor and appropriate standard software package examination of the venous system of the lower extremities. Multislice computed tomography was performed using X-ray computed tomography (Philips Brilliance 64). The study was performed using X-ray contrast iodine-containing medium (Omnipack-350) at the rate of 1 ml of the drug per kilogram of patient weight.
Research results and their discussion. the sonographic study found that the causes of trophic ulcers were impaired venous blood flow in the veins of the lower extremities due to severe varicose transformation and decompensated reflux, and changes in the deep venous system due to thrombosis of the deep veins.
Greater sensitivity and specificity of multislice computed tomography in the diagnosis of postthrombotic stenoses and obliterations were found compared with sonographic examination. This method is valuable in the study of the anatomy of the venous system, but does not allow to assess the parameters of hemodynamics (duration and degree of reflux, but only its presence).
Modern approaches to the treatment of genital prolapse in obese women
Authors: Safonov R. , Lazurenko V. , Lyashchenko O. , Afanasyev I. , Garkavenko K. , Chernyak O. 
Published: January 2022

Introduction. The problem of female genital prolapse (GP) remains in the sportlight of gynecologists, because despite the variety of surgical methods, there are still recurrences of the disease, which are associated not only with the failure of the restored ligaments, fascia, muscles, damaged pelvic floor and perineum, but with the imperfection of the operation. The solution of this problem is especially important in the treatment of patients with extragenital pathology, in particular obesity. The purpose: to optimize the treatment of genital prolapse in obese patients by determining an individual approach to planning surgical treatment taking into account the degree of obesity and concomitant pathology. Materials and methods. We examined 65 patients of which 20 had genital prolapse and obesity (main group), 25 had genital prolapse and normal weight (comparison group), 20 women did not have gynecological diseases and extragenital pathology made up control group. To diagnose obesity and determine its degree we calculated body mass index (BMI). To determine the degree of GP its quantitative assessment was used (POP-Q; 1996). Surgical intervention included transvaginal extirpation of the uterus without appendages, anterior colporrhaphy, colpoperineoraphy with levatoplasty, sacrospinal colpopexy. Transabdominal and laparoscopic colposacropexy in obese women were not used due to the presence of relative contraindications for laparoscopy (cardiovascular disease, respiratory pathology, adhesions, the condition after hernias’ surgery). Therefore, all operations on women with GP and obesity were performed transvaginally due to the inability to perform abdominal access. In comparison group transvaginal surgery was performed. All the groups under study were representative. Before the use of polypropylene mesh "Polymesh" to minimize purulent-septic complications associated with the use of synthetic prostheses aquadissection was performed with 0.9% saline with the addition of 1 g of ceftriaxone per 200 ml. After the operation, the women used suppositories with hyaluronic acid (revitax). Results. The results of surgical treatment have been analyzed and the following data were obtained: recurrences in the main and in the comparison group were 4% (2 women in whom operations were performed with the use of their own tissues without mesh prosthesis). Infectious complications, dyspareunia and pelvic pain were not observed. Conclusions. Surgical treatment of GP in obese women by using polypropylene mesh "Polymesh" for colposacropexy after transvaginal uterine extirpation increases the effectiveness of treatment and redduces the number of recurrences. Hydropreparation of the mesh with an antibacterial agent and postoperative use of hyaluronidase intravaginally helps to reduce purulent-septic complications of surgery and improves the patients’quality of life.
The results of sphincterometry in patients after sorgion treatment of extrasphintery anal fistula
Authors: Paliyenko R. , Mishura Z. 
Published: January 2022

More than 30% of patients with chronic paraproctitis have complex forms. They are most often complicated by external sphincter insufficiency due to deformation of the anal canal and scarring of the sphincters. The main principle of substantiation of surgical treatment of extrasphincteric pararectal fistulas is the individual choice of method in each particular patient. It is based on a comprehensive assessment of such factors as the etiology of the fistula, its distance from the edge of the anus, the relationship of the defect or fistula with the sphincter muscles apparatus, the severity of the scarring process, the functional state of the rectum.
Aim. Evaluation of the functional state of the sphincter apparatus of the rectum in patients with extrasphincteric pararectal fistulas in the preoperative, early and late postoperative periods.
Materials and methods. To determine the average indicators of anal sphincter function, basal tone and maximal compression force were measured using a sphincterometer "Sphinctometer STM-0164-SM" in 114 healthy individuals (68 men and 46 women) of different ages (16 to 80 years) who objectively had no signs of anal incontinence. In all patients, sphincterometry was preceded by a thorough proctological examination, and proctological pathology was excluded. Therefore, hemorrhoids or anal fissures, which lead to increased basal tone at rest, were excluded so as not to lead to falsified values.
Results. Indicators of the maximum compression force in the early postoperative period, ie the compression force of the external anal sphincter, in both groups were significantly lower than preoperative and ranged from 55 to 154 mm Hg, respectively. and from 63 to 137 mm Hg. This can be explained by the presence of a granulating wound in the pararectal tissue, edema and partial injury of the external anal sphincter during surgery.
In the late postoperative period, 6-12 months after surgery, the indicators of basal tone in both groups approached the preoperative indicators. In the main group, the study was performed in 22 patients. In these 22 patients, the tone of the internal anal sphincter did not differ significantly from the preoperative and ranged from 20 to 37 mm Hg. In the control group, in all 32 patients, the basal tone of the anal sphincter was significantly lower than before surgery - from 17 to 28 mm Hg. There were no clinical manifestations of incontinence at rest in either main or control groups.
In the late postoperative period in both groups a decrease in the maximum compression force of the external anal sphincter was revealed. In the main group the maximum compression force of the external anal sphincter varied from 71 to 186 mm Hg, and in the control group from 77 to 135 mm Hg, respectively.
Conclusion. Surgical treatment of patients with extrasphincteric pararectal fistulas significantly reduces the contractile function of the external anal sphincter in the postoperative period, regardless of the choice of surgery.
The severity of essential hypertension in terms of blood pressure values does not depend on NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphisms in the West-Ukrainian population
Authors: Sydorchuk Andrii , Sydorchuk Larysa 
Published: January 2022

Objective: to evaluate the association of essential arterial hypertension (EAH) and its severity with genes polymorphism of NOS3 (rs2070744) and GNB3 (rs5443) in West-Ukrainian population.
Materials and methods. One-hundred EAH patients (48 – healthy control) participated in the cohort case-control study. Blood pressure (BP), Creatinine, glucose, lipids panel were studied. GNB3 (rs5443) and NOS3 (rs2070744) genotyping performed by TaqMan probes (CFX96™Real-Time PCR). Risk assessed by Relative Risk, Odds Ratio and 95% Confidential intervals.
Results. A mutation of the NOS3 gene (786T>C, rs2070744) and the GNB3 gene (825C>T, rs5443) in the homozygous state in the West-Ukrainian population suffers from EAH occurs with a frequency of 16.67% and 8.33%, with no differences with the control subjects (p>0.05). In both groups dominate the T-allele of the NOS3 gene and the C-allele of the GNB3 gene: in patients by 12.5% ​​(c2=4.50; p=0.034) and 41.66% (c2=50.0; p<0.001), in the control – by 25.0% (c2=12.0; p<0.001) and 40.0% (c2=33.33; p<0.001), respectively. The results of the binary logistic regression analysis did not confirm the prediction of the EAH appearance by polymorphic variants of the NOS3 (rs2070744) and GNB3 (rs5443) genes. However, the TT genotype of the GNB3 gene (rs5443) increases unreliably the EAH risk almost twice as likely [OR=2.0; OR 95%CI:0.40-10.82; p>0.05]. Epidemiological analysis did not confirm the association of the NOS3 gene with the EAH severity. But T-allele of the GNB3 gene increases the probability of high normal BP almost 5 times [OR=4.86; OR 95%CI:0.99-24.75; p=0.042].
Conclusions: NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphisms are not associated with blood pressure values and EAH severity as well.
Active tourism vs. ‘Krajoznawstwo’: considerations about Polish history and geography in the context of sightseeing the area around the Lake Malta in Poznan
Authors: Rozmiarek Mateusz , Poczta Joanna 
Published: January 2022

Among the fastest growing branches of the world economy, tourism is considered to be one of the main ones. It provides an opportunity to travel and explore the surrounding reality, including the diverse landscape. One of the most popular forms of tourism is still active tourism, which has a mass range and thus offers a more accessible educational offer in the field of natural and cultural heritage, history or geography. In Poland this is referred as ‘Krajoznawstwo’. The concept has not yet found an equivalent name in English, but it is very much related to tourism. In the Polish capital of Greater Poland region – Poznan, the area around Lake Malta is one of the areas where one can see many objects of interest for people who collect information about the area in the context of gathering knowledge about the country and the region. Not only a geographer or a biologist, but also all those who are comprehensively interested in the natural and cultural heritage, and in the future even in the history of the local participants in the Olympic Games, will find some information there.
The main goal of the study is to is to show that “krajoznawstwo” has many features in common with active tourism and can thus be translated into English, where there is no clear equivalent word. The second goal is to present the area of the Malta Lake in Poznań as a case study, a place for the realization of sightseeing interests and active tourism.