bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interferon-Stimulated Exonuclease Gene 20 is A Prognosis and Predictive Biomarker and Correlated with Macrophages M2 Polarization in Glioblastoma: A Pan-Cancer Analysis
Authors: Jiang Haiping , Zhang Dongzhi , Liu Wenwu , Wang Lixiang , Aleksandrovich Karpov Denis , Chen Xin , Zhang Cheng , Wu Jianing , Yao Penglei , Sun Zhenying , Rong Xuan , Andrei Sokhatskii , Chen Xiaofeng , Zhao Shiguang 
Published: January 2022

Abstract
Background: Since the mutation of isocitrate dehydrogenase 1 was confirmed to be different in the tumor microenvironment of multiple cancer types, several researchers have included it in the study of tumor-infiltrating immune cells. Interferon-stimulated exonuclease gene 20 (ISG20) plays a role in the modulation of immunity and inflammation, and its abnormally high expression is conducive for the progression of tumor malignancy. However, whether ISG20 is associated with isocitrate dehydrogenase 1 mutation during tumorigenesis and cancer progression remains unknown to date. Methods: TIMER2.0, ONCOMINE, GEPIA2, TCGA and CGGA were applied to assess the clinical significance of ISG20 and its correlation with tumor-infiltrating immune cells in glioma. cBioPortal and MethSurv databases were used to observe the genetic and DNA methylation changes of ISG20, respectively. Visualization of data was mostly achieved by R language. Quantitative real-time PCR (qRT-PCR) and Immunohistochemistry (IHC) was performed to evaluate the mRNA and protein expression.Results: ISG20 expression was significantly different in most cancers. However, when we combined ISG20 with isocitrate dehydrogenase 1 mutation, we found significant differences only in glioblastoma (GBM). The clinical values of ISG20 in glioblastoma showed that the ISG20 overexpression was strongly associated with a worse overall survival (OS). Additionally, ISG20 was altered in 9% of samples of patients with GBM, and ISG20 expression was negatively correlated with its DNA methylation level. More importantly, ISG20 expression was associated with macrophage alternatively activated (M2) polarization in glioblastoma. Conclusions: ISG20 overexpression is conducive to malignant phenotype but adverse to OS, suggesting that ISG20 is a potential therapeutic target and prognosis and predictive biomarker in patients with GBM.
Surveillance of Hemodialysis Related Infections: A Prospective Multicenter Study
Authors: Hasanoglu İmran , Guner Rahmet , Sahin Suzan , Karadag Fatma Yilmaz , Parmaksiz Ergun , Atalay Haci Veli , Ecder Sabahat Alisir , Gulen Tugba Arslan , Ucar Zuhal Atan , Karabay Oguz , Sipahi Savas , Kilic Esra Kaya , Duranay Murat , Yapar Derya , Dogan Ibrahim , Ersoz Gulden , Turkmen Gulcan , Kiykim Ahmet Alper 
Published: January 2022

Abstract
There is neither a surveillance system nor a study to reveal the HD related infection rates in Turkey. We aimed to investigate the infection rate among HD outpatients and implement CDC’s surveillance system. A multicenter prospective surveillance study is performed to investigate the infection rate among HD patients. CDC National Healthcare Safety Network dialysis event (DE) protocol is adopted for definitions and reporting. During April 2016–April 2018, 9 centers reported data. A total of 199 DEs reported in 10035 patient-months, and the overall DE rate was 1.98 per 100 patient-months. Risk of blood culture positivity is found to be 17.6 times higher when hemodialysis was through a tunneled catheter than through an arteriovenous fistula. DE rate was significantly lower in patients educated about the care of their vascular access site. Staphylococcus aureus was the most causative microorganism among mortal patients. Outcomes of DEs were hospitalization (73%), loss of vascular access (18.2%), and death (7.7%). This first surveillance study revealed the baseline status of HD related infections in Turkey and showed that NHSN DE surveillance system can be easily implemented even in a high workload dialysis unit and be adopted as a nationwide DE surveillance program.
Design of a High-performance Flat Reflector Antenna Based on Conformal Transformation Optics
Authors: Nazarzadeh Fateme , Heidari Abbas Ali 
Published: January 2022

Abstract
In this paper, we design an implementable high-performance flat reflector based on conformal transformation optics. In the proposed 2-dimensional device, the rescaling refractive index approach is applied to overcome the sub-unit refractive index issue, resulting in an all-dielectric isotropic graded-index medium that is physically implementable. Rotating the permeability profile around the antenna axis yields the 3-dimensional profile of the flat reflector construction. The dielectric with continuous refractive index profile is split into eleven layers with a constant refractive index. The proposed antenna requires only dielectric layers with the permittivity of 1.1 to 3.8, making it realizable. Simulation results show that the proposed flat reflector can operate in wide frequency bandwidth. The simulated antenna gain is about 25.27 to 29.55 dBi in the 13-30 GHz frequency range with the side-lobe level below -15 dB. Design and simulation of the proposed antenna are done using COMSOL Multiphysics, and simulation results are validated with CST Studio Suite.
High-efficient low-cost characterization of materials properties using domain-knowledge-guided self-supervised learning
Authors: Xie Binglin , Yao Xianhua , Mao Weining , Rafiei Mohammad , Hu Nan 
Published: January 2022

Abstract
Modern AI-assisted approaches have helped material scientists revolutionize their abilities to better understand the properties of materials. However, current machine learning (ML) models would perform awful for materials with a lengthy production window and a complex testing procedure because only a limited amount of data can be produced to feed the model. Here, we introduce self-supervised learning (SSL) to address the issue of lacking labeled data in material characterization. We propose a generalized SSL-based framework with domain knowledge and demonstrate its robustness to predict the properties of a candidate material with the fewest data. Our numerical results show that the performance of the proposed SSL model can match the commonly-used supervised learning (SL) model with only 5 % of data, and the SSL model is also proven with ease of implementation. Our study paves the way to expand further the usability of ML tools for a broader material science community.
Chemical control of water hyacinth by some herbicides and their effect on some aquatic invertebrate
Authors: Mirzajani Alireza , Nezamabadi Noshin , Salavatian Seyed , Bagheri Siamak , Salahi Morteza , Rufchaei Rudabeh 
Published: January 2022

Abstract
Water Hyacinth (Eichhornia crassipes), regarded as one of worst aquatic weeds in the world, has been an invader in northern Iran, particularly in the Anzali Wetland. Herbicide application as a control method with respect to ecosystem health has been investigated. The effects of three herbicides, glyphosate (Roundup), Glufosinate-ammonium (Basta), and Bispyribac sodium (Nominee) were investigated on water hyacinth and on the survival of five aquatic invertebrates from the Anzali Wetland including Hemiptera, Amphipoda, Odonata, Ostracoda and Daphnia. The treatments consisted of 3 L/ha of glyphosate, 5 L/ha of Glufosinate-ammonium, and 0.3 L/ha of Bispyribac sodium. European Weed Research Council (EWRC) rating scale determining reduction of wet and dry weight of shoot was the basis of assessment to determine the effectiveness of the herbicides in the control of of water hyacinth. All herbicides were effective on water hyacinth while Roundup caused a significant reduction of shoot biomass and scored 98% on the EWRC scale. Bayesian mediation model was used to calculate total and decomposition effect of herbicides on animal groups. Based on the Bayesian mediation model, Basta showed the best performance with lowest probability of a negative effect (PEff<0=0.22). The accuracy of dosages and spraying of herbicides can be considered the most effective in inhibiting water hyacinth and the least destructive to living organisms.
Can Humidifier Reservoir Bacteria Colonize the Circuit During Mechanical Ventilation?
Authors: Li Tian-Ran. , Shi Lan-Ping. , Jia Yong-Gang. , Lau Ricky Wing Tong. , Pan Xia-Zhen. 
Published: January 2022

Abstract
Background:Although the circuit condensate, an ideal bacterial reservoir, may flow into the humidifier reservoir (HR), no study has investigated if HR-colonized bacteria colonize other circuit locations with airflow. Therefore, the objective of this study was to explore if bacterial growth in the HR leads to bacterial colonization in the ventilator circuit. Methods: A randomized controlled experiment was performed in a public tertiary hospital in Guangdong Province, China. In vitro mechanical ventilation models (n = 60), divided into sterile water samples (n = 30) and broth samples (n = 30), were established. Sterile water was used for humidification in the ventilation models. The sterile water group contained either Acinetobacter baumannii (n = 15) or Pseudomonas aeruginosa (n = 15) in humidifier water. The broth group was similar to the sterile water group, but brain heart infusion broth was added to the HR. After 24, 72, and 168 h of continuous ventilation, bacteria in the humidifier water and at different circuit locations were sampled and cultured, and the results were analyzed by the Chi-square test. The difference in bacterial concentration at the HR outlet was analyzed by the F test, and P < 0.05 was considered statistically significant.Results:Bacterial culture results of the sterile water samples were negative. Bacteria in the humidifier water continued to proliferate in the broth group, and the bacterial concentration at different times was not significantly different (P > 0.05). With prolonged ventilation, the bacterial concentration at the HR outlet increased (P < 0.05). During continuous ventilation, no bacterial growth occurred at 10 cm from the HR outlet and the Y-piece of the ventilator circuit. The bacterial concentration at the HR outlet was higher in the P. aeruginosa group than in the A. baumannii group (P < 0.05).Conclusions:Sterile water in the HR was not conducive to bacterial growth. Although bacteria grew in the HR and could reach the HR outlet, colonization of other circuit locations was unlikely.
Quality Assessment and Content Analysis of Youtube Videos on Trabeculectomy
Authors: DAGDELEN KENAN 
Published: January 2022

Abstract
PurposeThe aim of this study is to evaluate the accuracy, quality and reliability of the videos on trabeculectomy on YouTube which is an online video-sharing platform.Scope This paper aims to assess the quality and analyze the content of the videos on Trabeculectomy on YouTube. The material has been obtained by a video search carried out on the Youtube -online video platform- with the keyword “Trabeculectomy”. The material (videos) was examined and selected in accordance with the exclusion criteria (not being in English, duplicate videos, lack of title information of the video, being irrelevant to the subject, videos with only advertising content, videos with a pixel below 240, takes longer than 20 minutes). After the implementation of exclusion criteria, the first ten suitable videos were included in the evaluation.MethodologyRegarding the material, the parameters of the number of views, the number of likes, the number of dislikes, the number of comments, the video duration, the days since the video was uploaded were recorded. Thus, after carving out the secondary data, a number of statistical analyses were performed namely Shapiro-Wilks, Kruskall-Wallis, Mann-Whitney U and Backward Linear Regression. In this framework, statistical analyzes were made via using the Stata software. Statistical significance value (threshold) was accepted as %10 (p<0.1).ResultsAfter the videos were evaluated according to the upload source, it was found that 2 videos were downloaded by the individuals who is not a doctor, 6 videos from doctors and 2 videos from a commercial source. The number of subscribers of the YouTube channels on which these sources have been uploaded was significantly different from each other (p<0.1). When the videos were evaluated according to the information content they provided, it was found that 5 videos had low quality information content, 4 videos had medium quality information content, 1 video had good quality information content, and the video durations were also significantly different from each other (p<0.1). Moreover, it was statistically determined that the parameter affecting the number of views was the number of likes (p<0.1).ConclusionYouTube videos are essentially insufficient as an educational material and an English source of information for the Trabeculectomy. Health professionals need to pay more attention to online platforms so that patients can access accurate information.Categories:Medical Education, Medical Simulation, Surgery
Photocatalytic CO2 reduction with a quantum efficiency exceeding 60%: time-resolved spectroscopic and X-ray studies on Cu(I) photosensitizers in coordinative interaction with Co(II) phthalocyanine catalysts
Authors: Wang Jia-Wei , Zhang Xian , Karnahl Michael , Luo Zhi-Mei , Li Zizi , Huang Yanjun , Yu Jin , Hu Wenhui , Zhang Xiaoyi , Moonshiram Dooshaye , Ouyang Gangfeng 
Published: January 2022

Abstract
The utilization of a fully noble-metal-free system for photocatalytic CO2 reduction remains a fundamental challenge, demanding the precise design of photosensitizers and catalysts, as well as the exploitation of their intermolecular interactions to facilitate electron delivery. Herein, we have implemented triple modulations on catalyst, photosensitizer and coordinative interaction between them for high-performance light-driven CO2 reduction. In this study, heteroleptic copper and cobalt phthalocyanine complexes were selected as photosensitizers and catalysts, respectively. An over ten-fold improvement in light-driven reduction of CO2 to CO is achieved for the catalysts with appending electron-withdrawing substituents for optimal CO-desorption ability. In addition, pyridine substituents were implanted at the backbone of the phenanthroline moiety of the Cu(I) photosensitizers and the effect of their axial coordinative interaction with the catalyst was tested. The combined results of 1H NMR titration experiment, steady-state/transient photoluminescence, and transient absorption spectroscopy confirm the coordinative interaction and reductive quenching pathway in photocatalysis corroboratively. It has been found that the catalytic performances of the coordinatively interacted systems are unexpectedly reverse to those with the pyridine-free Cu(I) photosensitizers. Moreover, the latter system enables a very high quantum efficiency up to 63.5% at 425 nm with a high selectivity exceeding 99% for CO2-to-CO conversion. As determined by time-resolved X-ray absorption spectroscopy and DFT calculation, the replacement of phenyl by pyridyl groups in the Cu(I) photosensitizer favors a stronger flattening and larger torsional angle change of the overall excited state geometry upon photoexcitation, which explains the decreased lifetime of the triplet excited state. Our work promotes the systematic multi-pathway optimizations on the catalyst, photosensitizer and their interactions for advanced CO2 photoreduction.
Structure and succession dynamics of a Neotropical freshwater periphyton community, with emphasis on ciliates and their association with bacterial taxa
Authors: Giongo Adriana , Borges Luiz Gustavo dos Anjos , Simão Taiz L. Lopes , Eizirik Eduardo , Utz Laura 
Published: January 2022

Abstract
Periphyton communities in freshwater systems play an essential role in biogeochemical processes, but knowledge of their structure and dynamics lags far behind other environments. We used eDNA metabarcoding of 16S and 18S rRNA markers to investigate the formation and establishment of a periphytic community, in addition to morphology-based analyses of its most abundant group (peritrich ciliates). We sampled two nearby sites within a large Neotropical lake at four time points, aiming to assess whether periphyton establishment can be replicated on this local scale. Producers and denitrifiers were abundant in the community, illustrating the relevant role of biofilms in freshwater nutrient recycling. Among microeukaryotes, peritrich ciliates dominated the community, with genera Epistylis and Vorticella being the most abundant and showing a clear succession at both sites. Other ciliates were identified and, in some cases, their occurrence was strongly related to bacterial abundance. The structure and succession dynamics of both prokaryotic and eukaryotic components of periphyton differed between the two sites, in spite of their adjacent locations and similar abiotic properties, indicating that the establishment of these communities can vary even on a local scale within a lake ecosystem.
Effects of Lap Configuration on Mechanical Properties and Composition Distribution of Three-layer Overlapped Laser Weldments on Al/Cu Dissimilar Materials
Authors: Shin Joonghyeon , Kang Minjung 
Published: January 2022

Abstract
Battery cells are connected via bus-bars to meet performance requirements, such as power and capacity, and multiple layers of dissimilar materials functioning as anodes, cathodes, or bus-bars are overlapped and welded together. In laser welding, the formation of brittle intermetallic phases in the weld joint is inevitable and, in turn, deteriorates the mechanical properties. To obtain the desirable joint performance, appropriate welding parameters to avoid intermetallic phase formations and joint designs to release stress concentrations must be obtained. This study investigates the effects of lap configurations and process parameters on the tensile-shear load, T-peel load, and composition distribution when multi-layered joints of dissimilar materials are produced by laser welding. Two layers of 0.4 mm Al sheets were welded with a single 0.2 mm Cu sheet, which was emulated using electric vehicle battery interconnects. The results show that the penetration depth varied in accordance with the lap configuration even under the same heat input condition. The lap configuration and welding parameters influenced the composition distribution of the welds, as they altered the solidification rate, number of Cu/Al contact interfaces, and location of the high-density material. The failure load of the T-peel specimens was always lower than that of the tensile-shear specimens except for the Cu−Al−Al lap configuration. The T-peel load of the Cu−Al−Al lap configuration was similar to that of the tensile-shear load. When the stress-concentrated joint was homogeneous, it was more robust.
Optimization and Development of ITO-Free Plasmonic Gold Nanoparticles Assisted Inverted Organic Solar Cells
Authors: Gupta Vishal , Srivast Anju , Jain Reena , Sharma Vijay Kumar , Kumar Lalit 
Published: January 2022

Abstract
This paper focuses on the fabrication of an ITO-free plasmonic assisted inverted organic solar cell (OSC) constituting aluminium doped zinc oxide (AZO) as front cathode and ultraviolet (UV) filtering layer. The gold nanoflowers are introduced in the device to increase the efficiency using localized surface plasmon resonance (LSPR) shown by plasmonic nanoparticles. We used GPVDM software to first optimize the cell, based on the geometry AZO/ZnO/PTB7:PC71BM/MoO3/Ag where AZO acts as the transparent conducting oxide (TCO) cathode and UV filter, zinc oxide (ZnO) behaves as the electron transport layer (ETL), Thieno[3,4 b]thiophene-alt-benzodithiophene: [6,6]-phenyl C71 butyric acid methyl ester (PTB7: PC71BM) mixture as the active layer, molybdenum trioxide (MoO3) as the hole transport layer (HTL) and silver (Ag) serves as the anode layer. By modelling, we find that the optimized device with maximum power conversion efficiency (PCE) includes 10 nm thick HTL, 200 nm thick photoactive layer and ETL thickness of 30 nm. Using the optimized thicknesses, we have fabricated three structurally identical inverted OSCs: first having AZO as the front cathode (AZO based device); second with ITO as the front cathode (ITO based control device); third includes AZO as cathode and plasmonic gold nanoflowers embedded inside the active layer (plasmonic assisted AZO based device). The AZO based device exhibited the PCE value of 6.19%, slightly less than the efficiency of 6.83% for ITO based control device. However, a remarkable increase in the lifetime was achieved for AZO based device under UV assisted acceleration ageing test. The stability enhancement of AZO based device is because of the UV filtering properties of AZO which prevent degradation in the device due to UV exposure. Also, the PCE of AZO based device was further enhanced to 7.01% when plasmonic gold nanoparticles were included in the active layer. This work provides a feasible way to develop an ITO free plasmonic assisted inverted organic solar cell to achieve cost-effectiveness, high efficiency and stability.
Investigation of Posture/Balance Disorder and Pd-related Pain by Using Diffusion Tensor Imaging and Transcranial Doppler
Authors: Wang Xiaoying , Guo Wenhui , Zhang Yingying , Liu Dan , Gao Qing , Zhang Limei , Fu Kuang 
Published: January 2022

Abstract
Background: Posture/balance disorder and pain are both present in Parkinson's patients, but their neural basis remain unclear. To investigate the central mechanism of posture/balance disorder and PD-related pain in Parkinson's disease by using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS), combined with Transcranial Doppler (TCD). Results: It was found that the dose of levodopa, UPDRSⅡ and UPDRSⅢ were higher value in the group with higher score of posture/balance. In the more severe posture/balance disorder group, the fiber bundles of the prefrontal cortex, anterior cingulate cortex and basal ganglia were more likely to be affected. In addition, the DTI parameter values of the three brain regions had a significant correlation with the parameter values of the corresponding arteries. In the analysis of PD-related pain, the white matter fiber bundles from the midbrain to the basal ganglia increased in patients with PD-related pain. There were no statistic difference in prevalence of PD-related pain was found between different groups according to posture/balance. Conclusions: Posture and balance in PD were correlated with the severity of the disease and the dosage of compound levodopa. Posture and balance in PD were related to changes in the white matter integrity of the prefrontal cortex, anterior cingulate cortex and basal ganglia. The function of cerebral arteries had contributions to white matter integrity of these area and posture/balance. PD-related pain was positively correlated with sleep score. Patients with PD-related pain had an increase in the fiber projection from the midbrain to the basal ganglia. No relation was found between posture/balance disorder with PD-related pain.