bluuebunny/crossref_metadata_2025_split huggingface dataset:
ZNF521/EBF1 axis regulates AKR1B1 to promote the proliferation, migration, and invasion of gastric cancer cells
Authors: Cheng Yu , Ni Yi‐Jiang , Tang Li‐Ming 
Published: November 2022

AbstractAlthough the incidence and death rates of gastric cancer (GC) are decreasing, approximately one million new cases and 800,000 GC‐related deaths were reported worldwide in 2018. Currently, the oncogenesis of GC remains unclear, and the demand for novel treatment options are unmet. Here, we explored the role of aldo‐keto reductase family 1 member B (AKR1B1) in the progression of GC. The proliferation, migration, and invasion of GC cells were evaluated by CCK‐8 assay, wound healing assay, and transwell assay, respectively. The interaction between EBF transcription factor 1 (EBF1) and the promoter region of AKR1B1 was determined by luciferase reporter assay and chromatin immunoprecipitation (ChIP). Gene expression levels were measured by quantitative real‐time polymerase chain reaction (qRT‐PCR) and Western blotting assay. The expression of AKR1B1 was elevated in GC cells, resulting in increased cell proliferation, migration, and invasion. Meanwhile, EBF1 was a negative regulator of AKR1B1; its overexpression suppressed AKR1B1 expression and GC progression. Furthermore, knockdown of ZNF521 induced EBF1 expression, thus suppressing AKR1B1 expression and resulting in attenuated GC growth and invasiveness. Notably, knockdown of ZNF521 attenuated GC progression and was rescued by overexpression of AKR1B1. Our current study revealed a novel ZNF521/EBF1/AKR1B1 axis in GC and elaborated its important role in promoting GC progression, providing potential therapeutic targets for anti‐GC treatments.
Herder households' livelihood strategies as a response to payments for grassland ecosystem services in China
Authors: Li Zhidong , Liu Moucheng 
Published: November 2022

AbstractHerder households' response is critical in determining the effectiveness of payments for grassland ecosystem services (PGES). This study aimed to comprehensively analyze the influencing factors and processes of herder households' response to PGES using the sustainable livelihood approach. Here, we were the first to classify the ways herder households respond to PGES from the perspective of livelihood strategies, and proposed a sustainable livelihood indicator framework applicable to herder household research. According to the framework, we combined path analysis and statistical analysis to carry out empirical analysis in a typical area. The results show that the response strategies could be divided into three types, which rated by popularity from low to high, were reduction in herd counts (19.1%), livelihood diversification (27.7%) and industrial upgrading (53.1% max). Their formation was influenced by various factors, such as the PGES, vulnerability context, livelihood assets, and livelihood outcomes. In general, strict supervision (influence coefficient 0.46) helped reduce livestock headcounts, especially in small and medium households, which used to be the main bodies of overloading. Households with rising living standards tended to explore off‐farm livelihoods, but there were also some households that did so because of disagreement with PGES. Households with higher vulnerability and higher livelihood assets tended to cope with the shortage of grassland through industrial upgrading, thereby achieving a balanced utilization of grassland resources. This study not only makes an important supplement to PGES and sustainable livelihood theory but also provides an important reference for grassland ecological protection practices around the world.
Molecular Quantum Interface for Storing and Manipulating Ultrashort Optical Vortex
Authors: Trawi Firas , Billard Franck , Faucher Olivier , Béjot Pierre , Hertz Edouard 
Published: November 2022

AbstractLight beams carrying orbital angular momentum (OAM) have become over the past few years a subject of widespread interest with unprecedented applications in various fields such as optical communication, super‐resolution imaging, optical tweezers, or quantum processing. In the present work it is demonstrated that gas‐phase molecules can be used as a quantum interface to store an OAM carried by an ultrashort laser pulse. The interplay between spin angular momentum and OAM is exploited to encode the spatial phase information of light beams into rotational coherences of molecules. The embedded spatial structure is restored on‐demand with a reading beam by taking advantage of field‐free molecular alignment. The strategy is successfully demonstrated in CO2 molecules at room temperature. Apart from applications to broadband coherent buffer memory, this method opens new functionalities in terms of optical processing and versatile control of OAM fields as well as for a deeper understanding of their role on various molecular processes.
Tribology of dust‐stop seals of mixing machines
Authors: Fatourehchi Ehsan , Shahmohamadi Hamed , Rahmani Ramin , Rahnejat Homer , Johnson Mark , Wilson Ian 
Published: November 2022

AbstractDust stop seals are widely used in powder and rubber mixing industries. Design of the sealing system requires a continuous supply of pressurised lubricant, which is not recycled because of the risk of contamination. There is also the potential of large volume leakage of oil due to poor sealing, increasing operational costs and necessitating remedial measures to avoid environmental protection. Furthermore, the seal faces are prone to failure in relatively short periods of time due to reduced gap and lubricant leakage. The paper presents an analytical method and numerical predictions based on Reynolds equation under combined hydrodynamic and hydrostatic conditions with the entrant lubricant through hydraulically loaded feedholes. The validity of these methods is ascertained through comparison with a more complex but time‐consuming solution of Navier–Stokes equations. The numerical predictions allow for determining the prevailing tribological contact conditions and assessing its suitability for evaluating the sealing performance of mixing machinery.
Dual‐Function Fibrous Co‐Polypeptide Scaffolds for Neural Tissue Engineering
Authors: Ma Tienli , Yang Shangchih , Luo Shyhchyang , Chen Weili , Liao Shulang , Su Weifang 
Published: November 2022

AbstractThis paper reports dual‐function (high cell attachment and cell viability) fibrous scaffolds featuring aligned fibers, displaying good biocompatibility and no cytotoxicity. These scaffolds are fabricated through the electrospinning of a co‐polypeptide comprising molar equivalents of N6‐carbobenzyloxy‐l‐lysine and γ‐benzyl‐l‐glutamate, with the lysine moieties enhancing cell adhesion and the neural‐stimulating glutamate moieties improving cell viability. These new scaffolds allow neural cells to attach and grow effectively without any special surface treatment or coating. Pheochromocytoma (PC‐12) cells grown on these scaffolds exhibit better neuronal activity and longer neurite length, relative to those grown on scaffolds prepared from their respective homo‐polypeptides. When the scaffolds are partially hydrolyzed such that they present net positive charge and increased hydrophilicity, the cell viability and neurite growth both increase further. Accordingly, these novel co‐polypeptide fibrous scaffolds have potential applications in neural tissue engineering.
A Facile Strategy for Compatibilization of PLA/PBS Blends by Incorporating Camellia Seed Powder
Authors: Cai Hongjie , Cao Changlin , Zheng Yinglian , Liu Dingyong , Xia Xinshu , Sun Xiaoli , Liu Xinping , Xiao Liren , Qian Qingrong , Chen Qinghua 
Published: November 2022

AbstractUsing biodegradable blending materials is one of the most effective ways to address plastic pollution but it is hindered by its poor interfacial interaction along with high costs. Herein, an envirionmentally friendly filler, camellia seed powder (CSP)−a byproduct of camellia seed after defatting, is reported, which is first served as a compatibilizer in polylactic acid (PLA)/polybutylene succinate (PBS) blends without any other aids or complicated pretreatment, effectively toughening the PLA/PBS blends due to a better interfacial interaction. The results show that the toughness of composites increases with CSP content. With the addition of 30 phr CSP, its impact strength and elongation at break increase by 44.31% and 148.42%, respectively, as compared with the blend without CSP. The combined effects of improved interfacial bonding, reduced particle size of PBS and efficient stress transfer are responsible for the toughness enhancement. The compatibilization mechanism is proposed that ─COOH groups in PLA and PBS react with ─NH2in CSP. The above finding of CSP as a compatibilizer provides a facile and inexpensive strategy in the fabrication of high‐performance biodegradable materials.
Optimizing the ecological connectivity of landscapes
Authors: Hamonic François , Albert Cécile , Couëtoux Basile , Vaxès Yann 
Published: November 2022

AbstractIn this article, we consider the problem of optimizing the connectivity of a landscape under a budget constraint, by improving habitat areas and ecological corridors between them. We model this problem as a discrete optimization problem over graphs, in which vertices represent the habitat areas and arcs represent the connections between them. We propose a new flow‐based integer linear programming formulation that improves upon the existing models for this problem. By following an approach similar to Catanzaro et al. for the robust shortest path problem, we design an improved preprocessing algorithm that reduces the size of the graphs on which we compute generalized flows. Computational experiments show the benefits of both contributions, by enabling to solve instances of the problem larger than previous models. These experiments also show that several versions of greedy algorithms perform relatively well in practice, while returning arbitrarily bad solutions in the worst case.
Identifying personal beliefs of nursing staff about encouraging psychogeriatric nursing home residents in daily activities: A qualitative study
Authors: van Sambeek Joyce , Metzelthin Silke , Zwakhalen Sandra , Vluggen Stan 
Published: November 2022

AbstractAimTo identify personal beliefs of Dutch nursing staff about encouraging psychogeriatric nursing home residents in daily activities.DesignQualitative study following COREQ guidelines.MethodsFifteen semi‐structured interviews with Dutch nursing staff of wards hosting psychogeriatric residents were conducted in Spring 2021. Data were systematically analysed through deductive coding analysis in NVivo.ResultsMost nurses indicated to encourage residents frequently to perform activities independently, although many also indicated to take over tasks habitually. Nurses seemed to show sufficient awareness, reflected by adequate knowledge of what encouraging residents entailed and insight in the risks of not encouraging residents. Nurses' motivation to encourage residents seemed high, reflected by expressing multiple advantageous and few disadvantageous beliefs and a high willingness to encourage residents. Managerial support was perceived ambiguous. Self‐efficacy was perceived high, although little time, staffing shortages and resistance of residents reduced self‐efficacy. Nurses were often unable to anticipate such situations and expressed the need of skills, e.g. patience.
Fabrication of poly(ϵ‐caprolactone)/paclitaxel (core)/chitosan/zein/multi‐walled carbon nanotubes/doxorubicin (shell) nanofibers against MCF‐7 breast cancer
Authors: Bahmani Ehsan , Dizaji Babak Faraji , Talaei Sam , Koushkbaghi Shahnaz , Yazdani Hamid , Abadi Parvaneh Ghaderi‐shekhi , Akrami Mohammad , Shahrousvand Mohsen , Jazi Fariborz Sharifian , Irani Mohammad 
Published: November 2022

AbstractIn the present study, paclitaxel (PTX), multi‐walled carbon nanotubes (MWCNTs), and doxorubicin (DOX) have been simultaneously doped into the poly(ϵ‐caprolactone) (PCL)/chitosan/zein core‐shell nanofibers to increase its cytotoxicity for MCF‐7 breast cancers killing. The physico‐chemical properties of synthesized nanofibers were determined by scanning electron microscope, Fourier‐transform infrared spectroscopy, tensile strength, and degradation rate determinations. The in vitro release studies demonstrated the sustained release of drugs from core‐shell nanofibrous scaffold. The cytotoxicity and compatibility of core‐shell nanofibers were investigated by their treating with MCF‐7 breast cancer cells and L929 normal cells, respectively. PCL/PTX/chitosan/zein/MWCNTs/DOX core‐shell nanofibers containing 1 wt% MWCNTs, 100 μg ml−1 DOX and 100 μg ml−1 PTX had a high biocompatibility with a 84% MCF‐7 cancer cells killing. The in vivo studies revealed the synergic effects of MWCNTs and anticancer drugs on the tumor inhibition. This method could be considered as a new way for developing of MWCNTs loaded‐nanofibers for cancer treatment in future.
The impact of the COVID‐19 pandemic on school psychology internship outcomes
Authors: Morrison Julie Q. , Albritton Kizzy , Bernstein Elana , Davies Susan C. , Joseph Laurice , Mezher Katherine R. , Reynolds Jennifer , VanVoorhis Richard W. 
Published: November 2022

AbstractThe Ohio Internship Program in School Psychology was forced to adapt abruptly to the changing circumstances brought on by the novel coronavirus (COVID‐19) pandemic beginning in March 2020. The purpose of this study was to determine the extent to which the school psychology internship outcomes were negatively affected by the COVID‐19 pandemic in terms of supervisors' ratings of intern competencies, the number of students served by interns, and the outcomes of academic and behavior interventions supported by interns. Findings of the annual evaluation of the Ohio Internship Program in School Psychology for the school year directly affected by the pandemic (2020–2021) were compared to the findings for the year the pandemic began (2019–2020) and the 3 years before the start of the pandemic. The results provide evidence of gains in professional competencies and positive outcomes for students served by interns. The results also highlight racial disparities in the counts of students provided school psychological services during the pandemic. Implications for school psychology graduate preparation and practice are discussed.
Isobaric molar heat capacity model for the improved Tietz potential
Authors: Eyube Edwin S. , Notani Paul P. , Dlama Yabwa , Omugbe Ekwevugbe , Onate Clement A. , Okon Ituen B. , Nyam George G. , Jabil Yakubu Y. , Izam Musa M. 
Published: November 2022

AbstractIn this study, the improved Tietz potential was used to describe the internal vibration of diatomic molecules. By employing the expression for upper bound vibrational quantum number and canonical partition function of the system, equation for the prediction of constant pressure (isobaric) molar heat capacity of diatomic molecules was derived. The analytical model was used to predict the isobaric molar heat capacity of the ground state CO, BBr, HBr, HI, P2, KBr, Br2, PBr, SiO, and Cl2 molecules. The upper bound vibrational quantum number obtained for the molecules are 85, 100, 21, 21, 115, 301, 89, 157, 110, and 67. The calculated average absolute deviations are 2.3462%, 1.1342%, 2.3350%, 1.9078%, 0.7268%, 2.4041%, 1.7849%, 1.8989%, 2.5209%, and 2.1523% from experimental data. The results obtained are in good agreement with available literature data on gaseous molecules.
Pulmonary sarcoidosis with a cavitary lesion in the lung caused by a TNF‐α inhibitor: A case report
Authors: Hamada Eriko , Yamamoto Yoshifumi , Okuda Yosuke , Sakaguchi Kazuhiro , Suzuki Kentaro , Kai Yoshiro , Takeda Maiko , Hontsu Shigeto , Yamauchi Motoo , Yoshikawa Masanori , Sawabata Noriyoshi , Ohbayashi Chiho , Muro Shigeo 
Published: November 2022

AbstractA 28‐year‐old man with ankylosing spondylitis (AS) who was treated with a tumour necrosis factor‐alpha (TNF‐α) inhibitor, adalimumab, presented with newly detected multiple bilateral pulmonary nodules on chest computed tomography (CT). We suspected bacterial infection, including those caused by acid‐fast bacilli, or adalimumab‐related condition, such as sarcoidosis. After adalimumab cessation, no resolution of the pulmonary shadows was observed. Moreover, pulmonary cavitation appeared on chest CT at 7 weeks, prompting surgical lung biopsy. Acid‐fast bacteria culture of the lung tissue showed negative results. Pathological examination suggested that confluent granulomas associated with sarcoidosis might have obstructed the blood vessels, causing necrosis and lung cavitation. Consequently, prednisolone was initiated, and these shadows were reduced. After administering anti‐interleukin (IL)‐17A antibody for treatment of AS and prednisolone withdrawal, these shadows were not exacerbated. TNF‐α inhibitor‐induced sarcoidosis could cause cavitary lesions due to vascular invasion of granulomas.
Sustainability as fairness: A Rawlsian framework linking intergenerational equity and the sustainable development goals (SDGs) with business practices
Authors: Abramovich Nicolai , Vasiliu Alexandru 
Published: November 2022

AbstractThe article explores sustainability from a normative perspective to determine the legitimate uses of the concept in general and in business practices in particular. It is evident that when sustainability is used as an instrumental bluff to maximize profits, it is being diverted from its main objective: intergenerational and environmental justice. To avoid that trap, most of the justifications in favor of sustainable business adopt a structure based on the idea that sustainability conceived as a particular policy can bring benefits to society and to businesses. Strategic management based on stakeholder theory appears often as a pertinent solution to this problem: considering future generations as valid stakeholders would allow to integrate sustainability into the calculation. But stakeholder capitalism defends a pragmatist view that erases the borders between strategy and ethics. It considers sustainable goals as normative goods as well as strategic means for cost‐effective results. We think that it is insufficient to treat and understand sustainability as a matter of justice and fairness that ought to be addressed by businesses. We defend that in the case of sustainability only moral justifications are logically valid and consistent. Hence, we suggest an argument based on the Rawlsian conception of justice as fairness. Thinking behind the veil of ignorance in the original position allows to defend sustainability as an economic and social model needed not only to secure a fair distribution of basic goods or capabilities between generations, but also to preserve the consistency of any true commitment with the concept of fairness.
Ferrocene‐Based Polymeric Nanoparticles Carrying Doxorubicin for Oncotherapeutic Combination of Chemotherapy and Ferroptosis
Authors: Lin Jundong , Yang Huikang , Zhang Yixun , Zou Fen , He Huichan , Xie Wenjie , Zou Zhihao , Liu Ren , Xu Qianfeng , Zhang Jie , Zhong Guowei , Li Yuejiao , Tang ZhenFeng , Deng Yulin , Cai Shanghua , Wang Linyao , Huang Yugang , Zhuo Yangjia , Jiang Xinqing , Zhong Weide 
Published: November 2022

AbstractMono‐chemotherapy has significant side effects and unsatisfactory efficacy, limiting its clinical application. Therefore, a combination of multiple treatments is becoming more common in oncotherapy. Chemotherapy combined with the induction of ferroptosis is a potential new oncotherapy. Furthermore, polymeric nanoparticles (NPs) can improve the antitumor efficacy and decrease the toxicity of drugs. Herein, a polymeric NP, mPEG‐b‐PPLGFc@Dox, is synthesized to decrease the toxicity of doxorubicin (Dox) and enhance the efficacy of chemotherapy by combining it with the induction of ferroptosis. First, mPEG‐b‐PPLGFc@Dox is oxidized by endogenous H2O2 and releases Dox, which leads to an increase of H2O2 by breaking the redox balance. The Fe(II) group of ferrocene converts H2O2 into ·OH, inducing subsequent ferroptosis. Furthermore, glutathione peroxidase 4, a biomarker of ferroptosis, is suppressed and the lipid peroxidation level is elevated in cells incubated with mPEG‐b‐PPLGFc@Dox compared to those treated with Dox alone, indicating ferroptosis induction by mPEG‐b‐PPLGFc@Dox. In vivo, the antitumor efficacy of mPEG‐b‐PPLGFc@Dox is higher than that of free Dox. Moreover, the loss of body weight in mice treated mPEG‐b‐PPLGFc@Dox is lower than in those treated with free Dox, indicating that mPEG‐b‐PPLGFc@Dox is less toxic than free Dox. In conclusion, mPEG‐b‐PPLGFc@Dox not only has higher antitumor efficacy but it reduces the damage to normal tissue.
Tuning the Coordination Microenvironment of Central Fe Active Site to Boost Water Electrolysis and Oxygen Reduction Activity
Authors: Wang Shuhua , Huang Baibiao , Dai Ying , Wei Wei 
Published: November 2022

AbstractIn heterogeneous catalysis, single‐atom catalysts are the frontier and important prototypes for many reactions, and revealing the intrinsic structure–activity relationship is presently a critical task, but remains challenging. In this work, water electrolysis and oxygen reduction performances of FeXYiN3‐i (X, Y = B, C, O, P and S; i = 0, 1) moiety in Fe–porphyrin are studied by the first‐principles calculations, aiming at unraveling how and why tuning the coordination microenvironment of the active metal atom can improve the activity. It can be concluded that breaking the coordination shell symmetry breaks the well‐accepted standard scaling relationship, adjusts *O adsorption behavior and thus optimizes the oxygen evolution reaction (OER) activity, for example, to an extremely low overpotential of 0.17 V. In combination with the Fe atom spin configuration and ligand field theory, the dramatically improved OER activity can be well explained. In the present work, the significance of the coordination microenvironment of central metal atom in studies of electrocatalysis is highlighted.
Lithiophilic Nanowire Guided Li Deposition in Li Metal Batteries
Authors: Abdul Ahad Syed , Bhattacharya Shayon , Kilian Seamus , Ottaviani Michela , Ryan Kevin M. , Kennedy Tadhg , Thompson Damien , Geaney Hugh 
Published: November 2022

AbstractLithium (Li) metal batteries (LMBs) provide superior energy densities far beyond current Li‐ion batteries (LIBs) but practical applications are hindered by uncontrolled dendrite formation and the build‐up of dead Li in “hostless” Li metal anodes. To circumvent these issues, we created a 3D framework of a carbon paper (CP) substrate decorated with lithiophilic nanowires (silicon (Si), germanium (Ge), and SiGe alloy NWs) that provides a robust host for efficient stripping/plating of Li metal. The lithiophilic Li22Si5, Li22(Si0.5Ge0.5)5, and Li22Ge5 formed during rapid Li melt infiltration prevented the formation of dead Li and dendrites. Li22Ge5/Li covered CP hosts delivered the best performance, with the lowest overpotentials of 40 mV (three times lower than pristine Li) when cycled at 1 mA cm−2/1 mAh cm−2 for 1000 h and at 3 mA cm−2/3 mAh cm−2 for 500 h. Ex situ analysis confirmed the ability of the lithiophilic Li22Ge5 decorated samples to facilitate uniform Li deposition. When paired with sulfur, LiFePO4, and NMC811 cathodes, the CP‐LiGe/Li anodes delivered 200 cycles with 82%, 93%, and 90% capacity retention, respectively. The discovery of the highly stable, lithiophilic NW decorated CP hosts is a promising route toward stable cycling LMBs and provides a new design motif for hosted Li metal anodes.